gebhart/patrepeval huggingface dataset:
Distributed Routing Techniques for Internally Unbuffered Interconnection Networks (1993)

Abstract This paper deals with techniques for improving the performance of unbuffered banyan networks adopted in a switching fabric of a broadband packet switching network. We propose an arrangement of parallel banyan networks provided with output buffers that enables more than one packet to reach an output interface of the switch. Different solutions for the packet distribution to the banyan networks of the stack are investigated and the corresponding traffic performance is evaluated. Two types of packet addressing patterns are considered, depending on how many packets are allowed to address each switch outlet. The results obtained prove that a significant reduction in packet loss probability is possible with respect to a simple banyan network.
Label-Free DNA Detection Using a Near-Field Microwave (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Ureteral Graft in Urological Reconstruction: Clinical Experience and Review of the Literature (1995)

We report 7 cases in which grafts of ureter were used as tube and patch segments in urethral reconstruction and formation of a continent catheterizable stoma. The ureteral grafts survived without long-term stricture in all cases. Meticulous preparation of the graft and recipient bed is required for success, as previously demonstrated experimentally. When available, ureter is an excellent source of tissue for urological reconstruction.
Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo (1999)

3-Phosphoinositide-dependent protein kinase-1 (PDK1) expressed in unstimulated 293 cells was phosphorylated at Ser-25, Ser-241, Ser-393, Ser-396 and Ser-410 and the level of phosphorylation of each site was unaffected by stimulation with insulin-like growth factor-1. Mutation of Ser-241 to Ala abolished PDK1 activity, whereas mutation of the other phosphorylation sites individually to Ala did not affect PDK1 activity. Ser-241, unlike the other phosphorylation sites on PDK1, was resistant to dephosphorylation by protein phosphatase 2A1. Ser-241 lies in the activation loop of the PDK1 kinase domain between subdomains VII and VIII in the equivalent position to the site that PDK1 phosphorylates on its protein kinase substrates. PDK1 expressed in bacteria was active and phosphorylated at Ser-241, suggesting that PDK1 can phosphorylate itself at this site, leading to its own activation.
The Comparative Genomic Structure and Sequence of the Surfeit Gene Homologs in the Puffer Fish <i>Fugu rubripes</i> and their Association with CpG-Rich Islands (1997)

The puffer fish Fugu rubripes (Fugu) has a compact genome approximately one-seventh the size of man, mainly owing to small intron size and the presence of few dispersed repetitive DNA elements, which greatly facilitates the study of its genes at the genomic level. It has been shown previously that, whereas the Surfeit genes are tightly clustered at a single locus in mammals and birds, the genes are found at three separate loci in the Fugu genome. Here, Fugu gene homologs of all six Surfeit genes (Surf-1 to Surf-6) have been cloned and sequenced, and their gene structure has been compared with that of their mammalian and avian homologs. The predicted protein products of each gene are well conserved between vertebrate species, and in most cases their gene structures are identical to their mammalian and avian homologs except for the Fugu Surf-6 gene, which was found to lack an intron present in the mouse gene. In addition, we have identified conserved regulatory elements at the 5' and 3' ends of the Surf-3/rpL7a gene by comparison with the mammalian and chicken Surf-3/rpL7a gene homologs, including the presence of a polypyrimidine tract at the extreme 5' end of this ribosomal protein gene. The Fugu Surfeit gene homologs appear to be associated with CpG-rich islands, like the Surfeit genes in higher vertebrates, but these Fugu CpG islands are similar to the nonclassical islands characteristic of other fish species. Our observations support the use of the Fugu genome to study vertebrate gene structure, to predict the structure of mammalian genes, and to identify vertebrate regulatory elements. [The sequence data described in this paper have been submitted to the data library under accession nos. Y15170 (Surf-2, Surf-4), Y15171 (Surf-3, Surf-1, Surf-6), and Y15172 (Surf-5.)]
Incorporation of benzocarborane into conjugated polymer systems: synthesis, characterisation and optoelectronic properties (2013)

We present the novel 1,4-difunctionalisation of benzocarborane with organometallic groups suitable for cross-coupling and its subsequent insertion for the first time into conjugated polymer backbones. Copolymers with solubilised cyclopentadithiophene and diketopyrrolopyrrole derivatives were prepared by Stille polymerisation in good molecular weight. The physical, material and optoelectronic properties of the resulting polymers were investigated, demonstrating that benzocarborane acts similarly to a stabilised, electron-deficient cis-diene linker. We also report the first polymer field effect transistors incorporating a benzocarborane in the backbone.
The Critical Role of Processing and Morphology in Determining Degradation Rates in Polymer Solar Cells (2010)

Abstract With rapid increase in the efficiencies of polymer solar cells (PSCs) in the last few years, the issue of device stability is taking center stage in organic photovoltaic research. In this work, the effects of oxygen and light on the degradation of charge‐transport properties of the bulk polymer active layer are studied over short timescales. It is shown that although different processing techniques produce similar efficiencies for pristine devices, they result in different degradation rates. This variation in degradation rates is primarily due to slightly different morphology parameters, such as molecular packing or disorder in the film. Investigation reveals that the choice of processing for the devices should consider degradation rates as a critical parameter, not just the efficiencies of the pristine devices. It was found that degradation starts with broadening of the effective density of states due to photo‐oxidation. Both transient absorption and charge extraction by linearly increasing voltage (CELIV) measurements show increase in disorder in the films with progressive degradation. It is suggested that annealing provides the necessary thermal energy to reduce the trap states by flattening out the energy landscape of the pristine films, improving not only the efficiency, as reported previously, but also slowing the degradation rates.
Activation Status-Coupled Transient S Acylation Determines MembranePartitioning of a Plant Rho-Related GTPase (2007)

ROPs or RACs are plant Rho-related GTPases implicated in the regulation of a multitude of signaling pathways that function at the plasma membrane by virtue of posttranslational lipid modifications. The relationship between ROP activation status and membrane localization has not been established. Here we demonstrate that endogenous ROPs, as well as a transgenic His(6)-green fluorescent protein (GFP)-AtROP6 fusion protein, were partitioned between Triton X-100-soluble and -insoluble membranes. In contrast, an activated His(6)-GFP-Atrop6(CA) mutant protein accumulated exclusively in detergent-resistant membranes. GDP induced accumulation of ROPs in Triton-soluble membranes, whereas GTPgammaS induced accumulation of ROPs in detergent-resistant membranes. Recombinant wild-type and constitutively active AtROP6 isoforms were purified from Arabidopsis plants, and their lipids were cleaved and analyzed by gas chromatography-coupled mass spectrometry. In Triton-soluble membranes, wild-type AtROP6 was only prenylated, primarily by geranylgeranyl. The activated AtROP6 that accumulated in detergent-resistant membranes was modified by prenyl and acyl lipids. The acyl lipids were identified as palmitic and stearic acids. In agreement, activated His(6)-GFP-Atrop6(CA)mS(156) in which cysteine(156) was mutated into serine accumulated in Triton-soluble membranes. These findings show that upon GTP binding and activation, AtROP6 and possibly other ROPs are transiently S acylated, which induces their partitioning into detergent-resistant membranes.
Motion Of Pigments In Thin Paint Films (2018)

When thin paint layers are exposed to heat, evaporation of the solvent begins, and significant movement within the paint film occur, causing temperature and concentration gradients. A clear coat paint was used, which had a density of 988 kg/m 3 , viscosity of 240 cP and a surface tension of 26 mN/m and was mixed with spherical solid blue particles with a mean diameter 26 m were added to the paint at 2% concentration of the total mass. A knife edge was used to coat stainless steel substrates at different thicknesses and placed in a convection oven at 121 o C for 30 minutes. Images of the samples during the curing process were taken, showing how the pigments moved from low to high surface tension areas. Colour measurements were taken to show that increasing the thickness of the same paint significantly decreases the lightness value.
Plug-Load Control and Behavioral Change Research in GSA Office Buildings (2012)

The U.S. General Services Administration (GSA) owns and leases over 354 million square feet (ft2) of space in over 9,600 buildings [1]. GSA is a leader among federal agencies in aggressively pursuing energy efficiency (EE) opportunities for its facilities and installing renewable energy (RE) systems to provide heating, cooling, and power to these facilities. According to several energy assessments of GSA's buildings conducted by the National Renewable Energy Laboratory (NREL), plug-loads account for approximately 21% of the total electricity consumed within a standard GSA Region 3 office building. This study aims to provide insight on how to effectively manage plug-load energy consumption and attain higher energy and cost savings for plug-loads. As GSA improves the efficiency of its building stock, plug-loads will become an even greater portion of its energy footprint.
Cell therapeutics to treat diseases of the retina. (2008)

Background: The adult Bone Marrow Stem Cells (BMSCs) have distinct advantages over the other types of stem cells. They are multipotent, can be stored for upto 10 years and considered to be one of the best sources of hematopoietic and mesenchymal stem cells in an adult body. Genetically inherited diseases such as Retinitis Pigmentosa and Degenerative diseases such as Age Related Macular Degeneration remain unsolved as no definitive treatment is available to repair the damages caused to the RPE and Photoreceptors as of now. In this scenario, the technique of Bone Marrow aspiration & isolation of Mono Nucleated Cells (MNCs) & intra-vitreal injection of a very small volume of MNCs in human retinal disorders has been standardized and is safe and feasible for human studies (Mohanty et al) and autotransplantation of RPEs from periphery to affected area are underpractice(Coffey et al). In this study we report our research work on different approaches to the above diseases using cell therapeuticsStudy 1 Materials & methods: Ciliary Pigment Epithelium was harvested from donor eyes from Aditya Jyot Eye Hospital, Mumbai and was taken to and grown at NCRM lab. The cells were grown in the earlier reported methodology of Brenda et al (Science 2004). Results: The CPE derived Retinal stem cells grew well in the lab. However, the practical difficulties of harvesting the same in patients limited our further steps in this study. Study II:? Materials & methods: Cadaver eye RPE cells were harvested and grown using polymer scaffolds after transporting them over 6 to 12 Hrs. The RPEs were grown on conventional methods and in polymer scaffolds and were subjected to RT-PCR. Results: Human RPEs were able to grow without amniotic membrane and the same was proven by RT-PCR. This would make it possible for the peripheral RPEs taken from patients to be stored and later expanded and used for replacing the diseased cells of the central portion of the retina in future, without having to harvest the RPEs again. Study III: Materials & methods: Bone marrow mono nuclear cells were isolated and transported in cold containers (4-8oC) over a period of 6-12 Hrs and viability was evaluated.Results: The bone marrow mononuclear cells were viable up to 12 Hrs in our methodology with a viability of more than 95% making it possible for cells isolated from Chennai centre to be taken to Mumbai or any other destination within a reach of 12 Hrs for application as reported in earlier studies.Conclusion: The in-vitro expansion of RPEs without Human Amniotic Membrane is expected to open up a new possibility for treating the Retinal Degenerative Diseases. However an animal study is needed before clinical application. Intra vitreal application of Bone Marrow Mono Nuclear cells to treat RP and AMD as reported earlier are considered safe. We plan to undertake treatment and long term follow-up of more numbers of patients with RP and AMD.
TM scattering from hollow and dielectric-filled semielliptic channels with arbitrary eccentricity in a perfectly conducting plane (1998)

The behavior of TM wave scattering from hollow and dielectric-filled semielliptic channels in a perfectly conducting substrate is investigated. The scattered field is represented in terms of an infinite series of Mathieu functions with unknown coefficients. By applying the separation of variables and employing the partial orthogonality of the first-kind angular Mathieu functions, the unknown coefficients are obtained. Numerical results are given for the scattered-field patterns by the channels with different eccentricities and permittivities.
U‐48,753E: A potent, structurally novel antidepressant‐like agent (1983)

Abstract U‐48, 753E (trans‐3,4‐dichloro‐N‐(2‐(dimethylamino)‐cyclopentyl)‐propionanilide maleate) was compared to imipramine in a number of tests of antidepressant‐like activity and mechanisms of action. Although not structurally related to imipramine or other nontricyclic antidepressants, U‐48,753E was considerably more potent than imipramine in tests of norepinephrine potentiation, tetrabenazine antagonism, and behavioral despair. U‐48,753E displayed only moderate anticholinergic and no monoamine oxidase inhibitory activities. In vivo measurements of biogenic amine uptake indicated that U‐48,753E blocks norepinephrine, epinephrine, and serotonin uptake and that it is much more potent than imipramine, particularly regarding epinephrine uptake. U‐48,753E is most markedly distinguished by its potency in a test of alpha 2 ‐adrenergic desensitization. Extremely low repeated doses and single doses of U‐48,753E were effective at antagonizing the hypothermia induced by the alpha 2 agonist, clonidine. In contrast, imipramine required much higher, repeated doses to display similar activity. The alpha 2 desensitization by U‐48,753E is also manifest by a reduced biochemical sensitivity to clonidine; clonidine‐induced slowing of norepinephrine synthesis is antagonized by U‐48,753E pretreatment. Thus, U‐48,753E shares many antidepressant‐like properties with imipramine, but generally has greater potency and a much greater predilection for blocking epinephrine uptake and altering alpha 2 ‐adrenergic sensitivity.
Baseline predictors of response to treatment with darbepoetin-alpha (DA) in anemic patients with low-risk myelodysplastic syndrome (MDS) (2007)

7081 Background: Patients (pts) with MDS often develop anemia, resulting in fatigue and an increased requirement for transfusions. The erythropoiesis-stimulating agent (ESA) DA can raise hemoglobin (Hb) levels in low-risk MDS pts. Previous analyses suggest that baseline (BL) endogenous erythropoietin (eEPO) levels and French-American-British (FAB) disease category are predictors of response to ESAs. Methods: This was a phase 2, open-label, 52-week (wk) study of DA administered 500 mcg every 3 wks (Q3W) to anemic (Hb=11g/dL), low- or intermediate-risk MDS pts. Pts received 500 mcg DA Q2W if they did not respond by wk 7. The last DA dose was at wk 52; end of study was wk 53 or 55 for pts receiving DA Q2W or Q3W, respectively. The primary endpoint was % pts with an erythroid response (International Working Group criteria) by wk 13. Other endpoints included change from BL in Hb and FACT-F score. Exploratory analyses examined the incidence of erythroid responses adjusted by FAB category (refractory anemia [RA], RA with ringed sideroblasts [RARS], or RA with excess blasts [RAEB]). Results: Final 53/55 wk data will be presented. Results were stratified by whether pts received an ESA before enrollment (ESA-naive [ESA-N] vs ESA-treated [ESA-T]). ESA-T pts are a heterogeneous group and their data are difficult to interpret; thus, predictors of response will be presented for ESA-N pts only. Of 144 ESA-N pts, 56% had RA, 37% had RARS, and 7% had RAEB. Most ESA-N pts achieved the target Hb and had a major erythroid response ( Table ). Pts with RA were more likely to achieve a major erythroid response than pts with RARS or RAEB. For ESA-T pts, demographics and type/length of ESA treatment will be presented. Of all pts, serious adverse events (SAEs) were reported in 62 (30%) pts and treatment-related SAEs in 2 (1%) pts. Conclusions: FAB category may affect response to DA in MDS pts. Additional data will be presented on the effect of BL eEPO, transfusion needs, and previous ESA treatment on response and duration of response. [Table: see text]
Characterization of a cryptic <i>PML-RARA</i> fusion by mate-pair sequencing in a case of acute promyelocytic leukemia with a normal karyotype and negative <i>RARA</i> FISH studies (2019)

Acute promyelocytic leukemia (APL) is a time-critical hematologic neoplasm that is amenable to targeted therapy [1]. While the diagnosis of APL can be suspected based on the clinical presentation, ...
Reaction of alkyl- and aryldichloroboranes with ethyl diazoacetate at low temperature (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of alkyl- and aryldichloroboranes with ethyl diazoacetate at low temperatureJohn Hooz, John N. Bridson, Jose G. Calzada, Herbert C. Brown, M. Mark Midland, and Alan B. LevyCite this: J. Org. Chem. 1973, 38, 14, 2574–2576Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/jo00954a044https://doi.org/10.1021/jo00954a044research-articleACS PublicationsRequest reuse permissionsArticle Views454Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IBEM analyses on half-cell potential measurement for NDE of rebar corrosion (2007)

Corrosion of Reinforcement (rebar) is nondestructively estimated by the half-cell potential measurement. As is the case with other nondestructive testings (NDT), understanding of the underlying principles should be clarified in order to obtain meaningful results. Therefore, the measurement of potentials in concrete is analytically investigated. The effect of internal defects on the potentials measured is clarified numerically by the boundary element method (BEM). Thus, a simplified inversion by BEM is applied to convert the potentials on concrete surface to those on rebars, taking into account the concrete resistivity. Because the potentials measured on concrete surface are so sensitive to moisture content, concrete resistivity and surface condition, an inverse procedure to convert the potentials on concrete surface into those on rebars is developed on the basis of BEM. It is found that ASTM criterion is practically applicable to estimate corrosion from the potential values converted. In experiments, an applicability of the procedure is examined by accelerated corrosion tests of reinforced concrete (RC) slabs. For practical use, the procedure is developed where results of IBEM are visualized by VRML (Virtual Reality modeling Language) in three-dimensional space.
Direct chemical synthesis of well dispersed L1<sub>0</sub>-FePt nanoparticles with tunable size and coercivity (2015)

We report a simple, green, one-step solid-phase approach to synthesize well-dispersed single-crystal L1<sub>0</sub>-FePt nanoparticles with coercivity of more than 20 kOe.
A phase I clinical study of biweekly pemetrexed and gemcitabine in patients with advanced solid tumors (2004)

2141 Background: Pemetrexed (Alimta), a multi-targeted anti-folate, is synergisitic with gemcitabine in preclinical models. The optimal sequence and schedule of both drugs is currently unknown. This is the first study that will examine a biweekly schedule. The purpose of this study was to establish a maximum-tolerated dose (MTD) and recommend a phase 2 dose. Methods: Gemcitabine (G) was infused over 30 minutes, followed immediately by pemetrexed (P) given intravenously over 10 minutes once on day 1 every 14 days. The dose levels examined are shown in Table 1. Table 1. Dose Escalation Levels with DLTs Results: Thus far, 24 patients (13 female, 11 male) with 1 or no prior chemotherapy; median age 61 (range 39 – 80); ECOG PS 0 (11), 1 (13); diagnoses: lung (10), malignant pleural mesothelioma (3), pancreas (3), breast (2), atypical carcinoid tumor (2), head and neck (1), ovarian (1), skin (1), unknown primary (1) have received a current total of 87 cycles (range 1–13/ patient). MTD was established at dose level 5 (G 1500 mg/m2 and P 600 mg/m2) with two patients out of 6 experiencing neutropenic fever (NF). Dose level 4 was then expanded to treat 6 additional patients; no DLTs were seen in any of these 9 patients. Conclusions: G 1500 mg/m2 and P 500mg/m2 was selected as the phase 2 recommended dose. Preliminary response information suggests activity across multiple dose levels with specifics to be discussed at presentation. Plans are to study this schedule in phase 2 trials in many tumor types where G and P are known to be active. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly Eli Lilly