gebhart/patrepeval huggingface dataset:
Synthesis of Nucleosidic Peptides Related to Amicetin<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Nucleosidic Peptides Related to Amicetin1C. L. Stevens, T. S. Sulkowski, and M. E. MunkCite this: J. Org. Chem. 1966, 31, 12, 4014–4018Publication Date (Print):December 1, 1966Publication History Published online1 May 2002Published inissue 1 December 1966https://pubs.acs.org/doi/10.1021/jo01350a030https://doi.org/10.1021/jo01350a030research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Factors Determining the Attenuation of Chlorinated Aliphatic Hydrocarbons in Eutrophic River Sediment Impacted by Discharging Polluted Groundwater (2009)

This study explored the potential of eutrophic river sediment to attenuate the infiltration of chlorinated aliphatic hydrocarbon (CAH)-polluted groundwater discharging into the Zenne River near Brussels, Belgium. Active CAH biodegradation by reductive dechlorination in the sediment was suggested by a high dechlorination activity in microcosms containing sediment samples and the detection of dechlorination products in sediment pore water. A unique hydrogeochemical evaluation, including a delta2H and delta18O stable isotope approach, allowed to determine the contribution of different abiotic and biotic CAH attenuation processes and to delineate their spatial distribution inthe riverbed. Reductive dechlorination of the CAHs seemed to be the most widespread attenuation process, followed by dilution by unpolluted groundwater discharge and by surface water mixing. Although CAHs were never detected in the surface water, 26-28% of the investigated locations in the riverbed did not show CAH attenuation. We conclude that the riverbed sediments can attenuate infiltrating CAHs to a certain extent, but will probably not completely prevent CAHs to discharge from the contaminated groundwater into the Zenne River.
Which Codes Have 4-Cycle-Free Tanner Graphs? (2006)

Let C be an [n, k, d] binary linear code with rate R = k/n and dual C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">perp</sup> . In this correspondence, it is shown that C can be represented by a 4-cycle-free Tanner graph only if: pd <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">perp </sup> les lfloorradicnp(p-1)+n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /4+n/2rfloor where p = n - k and d <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">perp</sup> is the minimum distance of C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">perp </sup> . By applying this result, it is shown that 4-cycle-free Tanner graphs do not exist for many classical binary linear block codes
Lithography based resonant marker design for MRI catheter visualization (2016)

Background The unavailability of safe, conspicuous devices remains the chief barrier to wider clinical adoption of interventional cardiovascular magnetic resonance imaging. Active catheter receiver coils are conspicuous but their metallic transmission lines risk heating and their manufacture requires excessive device size. We have designed a clinical grade 5 Fr radio frequency (RF) resonator marker embedded directly into the catheter shaft using novel lithography techniques. We developed special manufacturing techniques to impart these circuits onto non-planar catheter surfaces. This approach eliminates (1) the bulky circuit components such as wire-wound coils and rigid capacitors as well as (2) long conductive cables, required for receiver coil-based visualization, that are subject to heating.
On the Chilopods of Alaska (1946)

In this paper is summarized what is now known of the chilopods of Alaska. It is occasioned by the coming into my hands of the material collected at several points in the territory, more particularly in the Watanuska Valley, by Dr. Joseph C. Chamberlin during 1943, 1944, and 1945. This material has increased substantially our knowledge of the centiped fauna of the region. Of the twenty-two forms here listed twelve species are described as new, among these species being representatives of three new genera and one new subgenus. Types of new species as well as all other specimens are retained at present in the author's collection at the University of Utah.
Intra‐articular lateral femoral condyle fracture following an ACL revision reconstruction (2009)

Lateral femoral condyle fractures following an ACL reconstruction are rare. To our knowledge, this is the first case report of a lateral femoral condyle fracture following a revision ACL reconstruction. The patient's fracture was intra-articular, had a significant amount of soft tissue damage, and was further complicated by a large defect involving the bone tunnel from the ACL revision reconstruction. The patient was treated with an open reduction and internal fixation and recovered well.
Automatic Face Recognition from Skeletal Remains (2007)

The ability to determine the identity of a skull found at a crime scene is of critical importance to the law enforcement community. Traditional clay-based methods attempt to reconstruct the face so as to enable identification of the deceased by members of the general public. However, these reconstructions lack consistency from practitioner to practitioner and it has been shown that the human recognition of these reconstructions against a photo gallery of potential victims is little better than chance. In this paper we propose the automation of the reconstruction process. For a given skull, a data-driven 3D generative model of the face is constructed using a database of CT head scans. The reconstruction can be constrained based on prior knowledge such as age and or weight. To determine whether or not these reconstructions have merit, geometric methods for comparing reconstructions against a gallery of facial images are proposed. First, active shape models are used to automatically detect a set of facial landmarks on each image. These landmarks are associated with 3D points on the reconstruction. Direct comparison of the reconstruction is problematic since in general the camera geometry used for image capture is unknown and there are uncertainties associated with the reconstruction and landmark detection processes. The first method of comparison uses constrained optimization to determine the optimal projection of the reconstruction on to the image. Residuals are then analyzed resulting in a ranking of the gallery. The second method uses boosting to learn which points are both reliable and discriminating. This results in a match/no-match classifier. Experimental evidence indicating that skull recognition from facial images can be achieved is presented.
Interaction of a synthetic amphiphilic polypeptide and lipids in a bilayer structure (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of a synthetic amphiphilic polypeptide and lipids in a bilayer structureJames H. Davis, Donna M. Clare, Robert S. Hodges, and Myer BloomCite this: Biochemistry 1983, 22, 23, 5298–5305Publication Date (Print):November 8, 1983Publication History Published online1 May 2002Published inissue 8 November 1983https://pubs.acs.org/doi/10.1021/bi00292a008https://doi.org/10.1021/bi00292a008research-articleACS PublicationsRequest reuse permissionsArticle Views203Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IMAAGEN trial safety and efficacy update: Effect of abiraterone acetate and low-dose prednisone on prostate-specific antigen and radiographic disease progression in patients with nonmetastatic castration-resistant prostate cancer. (2016)

5061 Background: IMAAGEN is a phase 2, multicenter study evaluating abiraterone acetate (AA) 1000 mg plus prednisone 5 mg (AA+P5) for the treatment of patients (pts) with nonmetastatic castration-resistant prostate cancer (nmCRPC). The primary endpoint was proportion of patients with ≥ 50% decrease in prostate-specific antigen (PSA) levels after 6 treatment cycles. Herein, we report updated results on secondary endpoints and safety from the IMAAGEN study (database cutoff: Oct. 2015). Methods: All enrolled pts had high-risk nmCRPC: PSA ≥ 10ng/mL or PSA doubling time ≤ 10 months at screening. Pts received AA+P5 daily; treatment cycles were 28 days. Secondary endpoints included time to PSA progression, time to radiographic progressive disease, and safety. Results: At the time of database cutoff, 44 (33.6%) of the 131 enrolled pts remained on study treatment, and Kaplan-Meier estimate of median follow-up was 40.0 months. Mean age was 72 (48-90) years. Median time to PSA progression was 28.7 months (95% CI 21.2, 38.2). With 31 confirmed progression events, the median time to radiographic progressive disease was not reached; however, in a sensitivity analysis including 15 additional unconfirmed progressions that led to initiation of new therapy, the median time to radiographic progressive disease was 41.4 months (95% CI 27.6, NE). 96.2% of pts had an adverse event (AE) (61.1% had a Grade ≥ 3 AE) and 43.5% had a serious AE (SAE) (41.2% had a Grade ≥ 3 SAE). 15.3% of pts had AEs resulting in study treatment discontinuation. Seven pts had AEs resulting in death. Conclusions: Treatment of high-risk nmCRPC patients with AA+P5 resulted in a median time to PSA progression of 28.7 months and a median time to radiographic progressive disease of 41.4 months. The safety profile of AA+P5 reported in this update is consistent with the safety profile from previously reported studies of AA 1000 mg in combination with either 5 or 10 mg prednisone. Clinical trial information: NCT01314118.
The Nod-Like Receptor Family Member Naip5/Birc1e Restricts <i>Legionella pneumophila</i> Growth Independently of Caspase-1 Activation (2007)

Similar to Ipaf and caspase-1, the Nod-like receptor protein Naip5 restricts intracellular proliferation of Legionella pneumophila, the causative agent of a severe form of pneumonia known as Legionnaires' disease. Thus, Naip5 has been suggested to regulate Legionella replication inside macrophages through the activation of caspase-1. In this study, we show that cytosolic delivery of recombinant flagellin activated caspase-1 in A/J macrophages carrying a mutant Naip5 allele, and in C57BL/6 (B6) macrophages congenic for the mutant Naip5 allele (B6-Naip5(A/J)), but not in Ipaf(-/-) cells. In line with these results, A/J and B6-Naip5(A/J) macrophages induced high levels of caspase-1 activation and IL-1beta secretion when infected with Legionella. In addition, transgenic expression of a functional Naip5 allele in A/J macrophages did not alter Legionella-induced caspase-1 activation and IL-1beta secretion. Notably, defective Naip5 signaling renders B6-Naip5(A/J) macrophages permissive for Legionella proliferation despite normal caspase-1 activation. These results indicate that the restriction of intracellular Legionella replication is more complex than previously appreciated and requires both Ipaf-dependent caspase-1 activation as well as functional Naip5 signaling.
Dissolution enhancement of a model poorly water-soluble drug, atorvastatin, with ordered mesoporous silica: comparison of MSF with SBA-15 as drug carriers (2015)

We believed that our findings can help the use of mesoporous silica materials in improving bioavailability of poorly water-soluble drugs.
THE FAR INFRARED SPECTRUM OF $(NH_{3})_{2}$ BETWEEN 80 AND $100 cm^{-1}$. (1994)

Author Institution: Department of Chemistry, University of California
937. Generation of Anti-LOX-1 Cytotoxic T Lymphocytes by AAV Manipulation of Dendritic Cells towards Preventing Atherosclerosis (2005)

The ultimate goal of this study is to analyze a hypothesis that a |[ldquo]|vaccine|[rdquo]| against atherosclerosis is feasible and viable.We think that cytotoxic T lymphocytes (CTL) can target cells involved in the earliest stages of atherogenesis, thus preventing initiation of atherosclerosis.It is well-known that activation of endothelium resulting in the expression of LOX-1, an endothelium-specific receptor for oxidized low density lipoprotein (Ox-LDL) is an early event in atherogenesis. If we can selectively target the cells that express LOX-1 this may stop the first step in atherogenesis, and then, logically, stop/prevent the progression of atherogenesis. However LOX-1 is a |[ldquo]|self|[rdquo]| antigen, not a viral or bacterial antigen and T cell responders against such self antigens are much more rare than against non-self antigens. Thus our method for generating CTL must be a very good one. Dendritic cells (DC) are the key cells which initiate the CTL response by presenting antigens to naive T cells, some of which respond. To optimize CTL response against these antigens, we used Adeno-Associated Virus (AAV) gene delivery of the LOX-1 antigen into DC (also called |[ldquo]|loading|[rdquo]| DC) and T cells. This direct genetic alteration of DC and CTL should result in the continuous and stable expression of both antigen and cytokine proteins. It was found that (rAAV)-based antigen-loading of dendritic cells generated significant and rapid (one stimulation/one week) cytotoxic T lymphocyte (CTL) responses in vitro against the LOX-1 self-antigen. Killing of synthetic and natural LOX-1-positive target cells could be demonstrated. There was also no evidence of natural killer cell involvement. These data extend our earlier studies, and suggest that the rAAV-loading of DC may be a particularly good protocol for generating CTL against self-antigens which may not otherwise be considered good targets due to their low immunogenicity. We next must observe if these anti-LOX-1 CTL can limit atherogenesis in an animal model.
New Approaches to Total Synthesis of Manzamine A, Ircinal A and Related Compounds. (1999)

New approaches to total asymmetric synthesis of ircinal A and manzamine A are described. The synthesis utilizes a highly efficient Diels-Alder reaction of the suitably functionalized dihydropyridinones and siloxydienes as a key step, followed by expedient conversion to manzamine A.
Risk of Hepatitis A Virus Infection among Sewage Workers in Israel (2000)

Sewage workers are exposed to a wide range of chemicals and biological agents, including the hepatitis A virus. Inasmuch as Israel is an endemic area for hepatitis A, it is unclear if sewage workers are at increased risk for hepatitis A or which factors contribute to such risk. The authors compared seropositivity of hepatitis A in 100 sewage workers with that in 100 blue-collar worker controls. Hepatitis A seropositivity was highly prevalent, but nonsignificant, in both sewage workers and controls (82% and 91%, respectively). In sewage workers, the major risk for serological positivity was age (odds ratio = 4.5, 95% confidence interval = 1.6, 12.4 for every 10 y). The factors associated negatively with seropositivity were years of education and years of seniority. The authors concluded that exposure to sewage is not a risk factor for hepatitis A infection in Israel, and, therefore, sewage workers do not require special attention in this regard.
Effects of Pegorgotein on Neurologic Outcome of Patients With Severe Head Injury (1996)

In this clinical trial of 463 patients with severe head injury, no statistically significant difference in neurologic outcome or mortality was observed between patients treated with pegorgotein and those receiving placebo.
Model reference adaptive fuzzy control of a permanent-magnet synchronous motor (2002)

This paper investigates the adaptive control of a fuzzy logic based speed controller for a vector-controlled permanent-magnet (PM) synchronous motor drive. A model-reference adaptive scheme is proposed in which the adaptation mechanism is executed by fuzzy logic based on the error and changes of error measured between the motor speed and the output of a reference model. The control performance of the adaptive fuzzy controller is evaluated by simulation for various operating conditions using the actual parameters of a prototype 1 kW PM synchronous servo drive. The design and implementation of the proposed adaptive fuzzy controller are considered and discussed.
Direct H/OR and OR/OR′ Metathesis Pathways in Ester Hydrogenation and Transesterification by Milstein’s Catalyst (2013)

Using DFT calculations we identify a low-energy reaction path connecting methyl acetate and Milstein’s trans-[Ru(H)2(PNN)(CO)] catalyst directly with acetaldehyde and trans-[Ru(H)(OMe)(PNN)(CO)]. The transformation represents a metathesis in which a hydride and an alkoxide are swapped between a metal center and an acyl group. The reaction leads to a simple mechanism systematically applicable to the diverse hydrogenation and dehydrogenative coupling chemistry that can be achieved by the given catalyst.
Chemical Implications for Antitumor and Antiviral Prostaglandins:  Reaction of Δ<sup>7</sup>-Prostaglandin A<sub>1</sub> and Prostaglandin A<sub>1</sub> Methyl Esters with Thiols (1997)

Prostaglandins (PGs) such as Δ12-PGJ2 and Δ7-PGA1 methyl ester that possess a cross-conjugated dienone unit exhibit unique antitumor and antiviral activities independent of intracellular cAMP levels. These compounds are transported reversibly into cultured cells and accumulate in nuclei via covalent interaction, eliciting growth inhibition. PGA1 methyl ester, a simple cyclopentenone analog, is less potent. The unique cellular behavior of the dienone PGs correlates well with their chemical properties. The PGs react specifically with thiol nucleophiles such as glutathione. Michael addition of thiols to Δ7-PGA1 methyl ester, an alkylidenecyclopentenone derivative, occurs facilely at the endocyclic C(11) position rather than at the C(7) position. This process is reversible, and in solution phase, the adducts are in equilibrium with considerable amounts of free PG and thiols. However, the reaction of this PG with Sepharose-bound thiols, regarded to be plausible mimics of protein thiols, is irreversible, and the resulting adducts are dissociated only by alkali treatment. On the other hand, PGA1 methyl ester reacts with soluble or polymer-anchored thiols at lower rates than Δ7-PGAl methyl ester, but the resulting thiol adducts are substantially more stable than those of the dienone PGs. This tendency of the PGA1 methyl ester causes its equilibrium to shift to the adduct formation. The reversibility of the Michael reaction of PGs with thiols is consistent with their intracellular behavior and biological activities. Since glutathione adducts of PGs have no antiproliferative activities for cancer cells, the intracellular free PGs are presumed to interact with target molecules to cause cell growth inhibition. The involvement of the ATP-dependent glutathione S-conjugate export pump (GS-X pump) in the efflux of PGs is discussed. Thus, the marked difference in potency of the dienone and enone PGs is explained by considering the combined kinetic and thermodynamic properties and the action of the GS-X pump.
Mucoepidermoid Carcinoma of the Hypopharynx (1981)

Mucoepidermoid carcinoma is most commonly found in the parotid gland. It rarely occurs in the larynx and hypopharynx. There are only 32 reported cases from these areas. A case of a mucoepidermoid carcinoma of the hypopharynx is presented. Although the initial impression was squamous cell carcinoma, glandular structures were found in metastatic lymph nodes in the neck specimen, and after mucicarmine stains were positive, the final diagnosis was changed to mucoepidermoid carcinoma. This case illustrates the difficulty in diagnosing mucoepidermoid carcinoma, especially in unexpected locations. Differentiating mucoepidermoid carcinoma from other neoplasms is important because treatment may differ depending on the diagnosis. The pathologic spectrum of mucoepidermoid carcinoma is presented, and the management of these tumors with respect to the histologic grade is discussed.
Catecholamines can mediate stress-related effects on tumor progression (2008)

Studies have implicated behavior as a factor that can influence several aspects of health and have described the complex bidirectional interactions among the CNS, the endocrine system and the immune system that are involved. There is evidence that psychological factors can affect the incidence and progression of some cancers in humans. The hypothesis that stress could be a cofactor is supported by data obtained from animal models. Catecholamines, norepinephrine in particular, have been shown to directly affect various aspects of tumor development that is separate from the well-characterized effects on the cellular immune response to immunogenic tumors. Studies have shown that norepinephrine can directly affect tumor cell behavior and gene expression, further suggesting another mechanism for stress-related modulation of tumor progression. This line of research further suggests that interventions targeting components of the activated sympathetic-adrenal-medullary axis, or the utilization of β-adrenergic receptor-blocking agents, may represent new strategies for slowing down the progression of malignant disease and improving cancer patients' quality of life.