gebhart/patrepeval huggingface dataset:
Orientation de la Fragmentation en Spectrométrie de Masse Par Introduction de Groupements Fonctionnels. XII—Ethylene Acetals Derives de Cyclopentanones et Cyclopentanones α Substituees (1974)

Abstract La fragmentation des éthylénecétals des cétones α substituées a été étudiée. Un nou‐veau type de transposition en spectrométrie de masse a été mis en évidence.
Effect of acetaminophen on the leukocyte-labeling efficiency of indium oxine In 111. (1983)

The effect of acetaminophen on the labeling efficiency of leukocytes with indium oxine In 111 was studied. A blood sample was obtained from eight healthy men before and after they received acetaminophen 650 mg every four hours for 24 hours. After dividing the plasma from each sample into three portions, leukocytes were separated and labeled with indium oxine In 111. In an in vitro study, 200 ml of blood was obtained from one of the men, and the plasma was separated into four portions. Acetaminophen in 95% ethanol was added to three of the plasma fractions to produce acetaminophen concentrations of 4, 20, and 100 micrograms/ml; ethanol was added to the fourth fraction as a control. Each plasma fraction was then subdivided into three aliquots, and leukocytes were labeled as in the in vivo study. Mean leukocyte labeling efficiencies in both studies were calculated from the ratios of leukocyte radioactivity to initial radioactivity in the samples, expressed as percentages. Leukocyte labeling efficiencies before acetaminophen administration ranged from 79 to 85%; after administration, labeling efficiencies ranged from 70 to 87%. No significant differences in mean labeling efficiency before and after acetaminophen administration were noted in any of the subjects. Leukocyte labeling efficiencies in all in vitro plasma fractions were reduced, ranging from 54 to 63%, but no significant differences in labeling efficiency between any of the plasma fractions were found. Using the labeling procedures in this study, exposure of leukocytes from healthy men to acetaminophen in vivo or in vitro does not affect labeling efficiency with indium oxine In 111.
Effect of Sulbactam on Anti‐Pseudomonal Activity of β‐Lactam Antibiotics in Cells Producing Various Levels of the MexAB‐OprM Efflux Pump and β‐Lactamase (2000)

The beta-lactamase inhibitor, sulbactam, was tested for beta-lactamase inhibitory activity in Pseudomonas aeruginosa cells producing various levels of both the MexAB-OprM efflux pump and beta-lactamase. We found that sulbactam lowered the MICs of cefoperazone and piperacillin by inhibiting the beta-lactamase 8-fold in the cell producing a constitutively high level of AmpC-type beta-lactamase and a wild-type level of MexAB-OprM pump compared with that without sulbactam. The MICs of cefoperazone and piperacillin in the cell producing a constitutively high level of both the efflux pump and beta-lactamase under the presence of sulbactam were 8 and 4 times, respectively, lower than that without sulbactam. The MICs of sulbactam in the cell producing a constitutively high and a wild-type level of the efflux pump were 16- and 8-fold higher, respectively, than that in the mutant lacking the efflux pump. We concluded that sulbactam exerts potent beta-lactamase inhibitory activity in the cell producing a high level of efflux pump, in spite of the fact that sulbactam serves as a substrate of the MexAB-OprM pump. Increasing amounts of sulbactam over the weight of beta-lactams further strengthen the effect of beta-lactam antibiotics.
Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine (2014)

Dendritic cells (DCs) are well established as potent antigen-presenting cells critical to adaptive immunity. In vaccination approaches, appropriately stimulating lymph node-resident DCs (LNDCs) is highly relevant to effective immunization. Although LNDCs have been implicated in immune response, their ability to directly drive effective immunity to lymph-borne antigen remains unclear. Using an inactive influenza vaccine model and whole node imaging approaches, we observed surprising responsiveness of LNDC populations to vaccine arrival resulting in a transnodal repositioning into specific antigen collection sites within minutes after immunization. Once there, LNDCs acquired viral antigen and initiated activation of viral specific CD4(+) T cells, resulting in germinal center formation and B cell memory in the absence of skin migratory DCs. Together, these results demonstrate an unexpected stimulatory role for LNDCs where they are capable of rapidly locating viral antigen, driving early activation of T cell populations, and independently establishing functional immune response.
A 2.5V 14-bit ΣΔ CMOS-SOI capacitive accelerometer (2004)

This paper presents a 2.5V 14b fully-differential /spl Sigma//spl Delta/ interface IC in 0.25/spl mu/m CMOS based on a programmable front-backend architecture for a high-resolution SOI capacitive accelerometer. Capacitive resolution is 22aF at 75Hz (RBW = 1 Hz), equivalent to 110/spl mu/g with a dynamic range of 85dB and sensitivity of 0.5V/g. The chip occupies 2mm/sup 2/ and consumes 6mW.
Relationship between Local Structure and Oxide Ionic Diffusion of Nd2NiO4+^|^delta; with K2NiF4 Structure (2014)

The relationship between the local structure and oxide ionic conduction of Nd2NiO4+δ possessing the K2NiF4 structure was investigated. Various oxygen nonstoichiometry samples of Nd2NiO4+δ prepared with different annealing oxygen partial pressures were examined. The local structure related to oxide ionic conduction was determined by the Nd K-edge extended X-ray absorption fine structure. The oxide ionic conductivity and surface exchange coefficient were estimated using electronic conductivity relaxation methods. The activation energy for the oxide ionic conductivity was found to have a direct correlation to the surface exchange coefficient. The bottleneck size for oxide ion conduction was strongly correlated to the oxide ionic conduction of interstitial oxygen and the oxygen surface exchange rate.
Strain Dependent Variation of Immune Responses to A. fumigatus: Definition of Pathogenic Species (2013)

For over a century microbiologists and immunologist have categorized microorganisms as pathogenic or non-pathogenic species or genera. This definition, clearly relevant at the strain and species level for most bacteria, where differences in virulence between strains of a particular species are well known, has never been probed at the strain level in fungal species. Here, we tested the immune reactivity and the pathogenic potential of a collection of strains from Aspergillus spp, a fungus that is generally considered pathogenic in immuno-compromised hosts. Our results show a wide strain-dependent variation of the immune response elicited indicating that different isolates possess diverse virulence and infectivity. Thus, the definition of markers of inflammation or pathogenicity cannot be generalized. The profound understanding of the molecular mechanisms subtending the different immune responses will result solely from the comparative study of strains with extremely diverse properties.
Prophylaxis Against Postoperative Endophthalmitis in Cataract Surgery (2011)

Yiu, Glenn MD, PhD; Young, Lucy MD, PhD; Gilmore, Michael PhD; Chodosh, James MD, MPH Author Information
Comparison of Two Ester Prodrugs of Methylprednisolone on Early Neurologic Recovery in a Murine Closed Head Injury Model (1989)

In prior work, methylprednisolone succinate, sodium salt (MPSS) has been shown to enhance the early neurologic recovery of moderately or severely head-injured mice. In the present study, the relative cerebroprotective potency and efficacy of MPSS was compared to another methylprednisolone ester prodrug, methylprednisolone suleptanate, sodium salt (U67590A). Male CF-1 mice received a 900 g-cm concussive head injury followed within 5 min by an intravenous bolus dose of vehicle, MPSS, or U67590A. At 1 h postinjury, the neurologic status was evaluated blindly using a grip test. Both methylprednisolone esters were found to enhance early neurologic recovery after this severe head injury. However, U67590A was four to eight times more potent than MPSS. Either a 7.5 or 15.0 mg/kg dose of U67590A produced a significant improvement in recovery while a 60.0 mg/kg dose of MPSS was required. The maximal efficacy of the two prodrugs was equal. These results indicate that the ester of methylprednisolone can greatly influence the steroid's cerebroprotective potency and that U67590A may be superior in this regard to MPSS for the acute treatment of CNS injury.
Dynamic light scattering evidence for a lignand-induced motion between the two domains of glucoamylase G1 of <i>Aspergillus niger</i> using heterobivalent substrate analogues (1999)

International audience
Epigenetic approaches to psychiatric disorders (2010)

Psychiatric diseases place a tremendous burden on affected individuals, their caregivers, and the health care system. Although evidence exists for a strong inherited component to many of these conditions, dedicated efforts to identify DNA sequence-based causes have not been exceptionally productive, and very few pharmacologic treatment options are clinically available. Many features of psychiatric diseases are consistent with an epigenetic dysregulation, such as discordance of monozygotic twins, late age of onset, parent-of-origin and sex effects, and fluctuating disease course. In recent years, experimental technologies have significantly advanced, permitting indepth studies of the epigenome and its role in maintenance of normal genomic functions, as well as disease etiopathogenesis. Here, we present an epigenetic explanation for many characteristics of psychiatric disease, review the current literature on the epigenetic mechanisms involved in major psychosis, Alzheimer's disease, and autism spectrum disorders, and describe some future directions in the field of psychiatric epigenomics.
The effect of linear induced phase fluctuations on the gain of a Cerenkov FEL (2004)

In a Cerenkov FEL (CFEL), the phase velocity of an EM wave is determined by geometry (i.e., waveguide radius and inner liner radius) and by material parameters (i.e., the dielectric constant of the liner). Changes or fluctuations in any of these parameters induce changes (or fluctuations) in the phase velocity of the EM wave and thus can degrade the gain of the CFEL. To investigate the effect of such fluctuations on the gain, a method is developed to describe the effect of a slowly varying inner liner radius on the EM wave propagation and consequently on the gain of the CFEL. As an example, results for a low gain, 800 mA Cerenkov FEL operating at a frequency of 50 GHz and a maximum beam voltage of 100 kV are presented.
Fluorescent lamp cathodes: Voltage-controlled preheating characteristics (1998)

The paper provides a method for measuring the emission time for the voltage-controlled preheating mode of a fluorescent lamp cathode. The method is based on monitoring the lamp voltage. The paper presents the difference between the thermionic emission curves obtained by the method based on the ratio of hot to cold coil resistance (Rh/Rc ) and by the lamp voltage monitoring method. It is supposed that the Rh /Rc method curve is mainly influenced by the heterogeneous cathode heating. The cathode is composed of the filament coil and the emissive material, the specific heat capacities of which differ. It is believed that this difference makes it difficult to create a thermal balance in the whole cathode when the emissive coating reaches the emission temperature at a time soon after the initial current surge. This makes it difficult to describe the thermionic emission characteristics dynamically by the Rh/R c method. An equation is proposed for the thermionic emission curve provided by the lamp voltage monitoring method. Energy supplied to the cathodes until the emission time is reached is examined in terms of the average resistance of the cathode.
Hyperdynamic sepsis in baboons: II. Relation of organ damage to severity of sepsis evaluated by a newly developed morphological scoring system. (1992)

The purpose of our study was to set up a baboon hyperdynamic sepsis model with live bacteria administration, which produces within 8 hr an organ failure comparable to human pathological conditions. Twelve adult male baboons were instrumented and studied for 8 hr under pentobarbital (2-3 mg/kg BW/hr) anesthesia breathing spontaneously. The animals were divided into two groups: 1) Live Escherichia coli were infused intravenously at a dose of 1.0-2.0 x 10(10) CFU/kg BW over 8 hr; 2) Live E. coli were infused i.v. at a dose of 5 x 10(8) CFU/kg BW over 2 hr. Organ damage was monitored by a newly developed scoring system. Organ damage was clearly dependent on the concentration of the bacterial challenge. Bacterial challenge at a dosage of 5.0 x 10(8) produces insignificant hemodynamic effects, while the 1.0-2.0 x 10(10) animals demonstrated massive hemodynamic alterations and needed much higher fluid support. The higher E. coli dosage was associated with an overwhelming organ damage seen, e.g., from the lung weight (12 g/kg BW vs. 9.6 g/kg BW with the lower dosage) or from the organ failure score, which is based on macroscopic pathology, histological data and organ weight. The percentage of animals with one, two, or three organ failures (organ failure score > or = 2) was higher in baboons with the higher dosage/kg BW. Therefore, we believe that the less severe organ damage in the acute phase after 8 hr with live bacteria 5 x 10(8) CFU/kg BW infusion over 2 hr is better to monitor the efficacy of newly developed therapeutic regimens, since in another set of experiments this model still produces lethal organ damage (80%) in a subchronic setting over 72 hr.
Improved tuning accuracy of fiber grating lasers using a linear variable differential transformer (2001)

Abstract A microprocessor‐controlled feedback system using a linear variable differential transformer to measure the compression of a fiber Bragg grating with a view to improve the tuning accuracy of a fiber grating laser is reported. This technique overcomes the large hysteresis of the PZT actuator normally used to compress the grating. A tuning range of about 20 nm with a readout wavelength accuracy of better than ±0.05 nm was achieved. © 2002 John Wiley & Sons, Inc. Microwave Opt Technol Lett 32: 37–40, 2002.
Driver Accelerator Design for the 10 kW Upgrade of the Jefferson Lab IR FEL (2000)

An upgrade of the Jefferson Lab IR FEL is now under construction. It will provide 10 kW output light power in a wavelength range of 2-10 microns. The FEL will be driven by a modest-sized 80-210 MeV, 10 mA energy-recovering superconducting RF (SRF) linac. Stringent phase space requirements at the wiggler, low beam energy, and high beam current subject the design to numerous constraints. These are imposed by the need for both transverse and longitudinal phase space management, the potential impact of collective phenomena (space charge, wakefields, beam break-up (BBU), and coherent synchrotron radiation (CSR)), and interactions between the FEL and the accelerator RF system. This report addresses these issues and presents an accelerator design solution meeting the requirements imposed by physical phenomena and operational necessities.
Linear prediction of time-varying MIMO systems using Givens rotations (2011)

MIMO systems require eigenmode information at the transmitter to exploit the multiplexing gain of the channel. In practice, the eigenmode information available at the transmitter after feedback is noisy and outdated. One of the efficient feedback methods used in MIMO systems involves the decomposition of unitary matrices into Givens rotations. This entails the possibility to update the eigenmodes by predicting the Givens rotations. In this paper, two MIMO precoder prediction schemes based on channel prediction at the mobile station (MS) and Givens parameters prediction at the base station (BS) are proposed. The system capacity of the two schemes is evaluated and compared by using a simulation on a time-varying MIMO channel. Simulations show that both prediction schemes improve the system performance; however, channel prediction at the MS has better performance than Givens prediction at the BS. Despite a lower performance, Givens prediction at the BS reduces the number of parameters to be tracked and is suitable for variable delay systems.
Factors that enable the formation of porous strut morphology in “Swiss Cheese” viscoelastic polyurethane foam technology (2016)

ABSTRACT Several factors were investigated that affect porous strut morphology in the Highly Porous Supersoft Viscoelastic Foam. Porous strut morphology and high air permeability of the Swiss‐Cheese TDI VE technology were found to be enabled by the combination of immiscible polyether polyols mixed with a third, highly hydrophobic polyol of high equivalent weight that is immiscible with either of the first two polyether polyols. Completely “punctured through” pores in struts were observed more frequently in foam samples where an isocyanate index of 90 versus 100 was employed. When isocyanate index is fixed to 90, it was found that a poly(1,2‐butylene oxide) (“PBO”) monol level of ≥3.0 parts per hundred polyol (pphp) was needed to see the first signs of a “punctured” pore strut morphology. Studies show that a “high‐Eq.Wt.‐hydrophobic‐polyol‐leaving‐voids” model is consistent with observed results. Hydrophobic polyols that allowed the formation of porous strut morphology included BO‐4000 monol (Eq.Wt. ∼ 4000) and PBD‐10000 diol (Eq.Wt. ∼ 5000). The use of these hydrophobic polyols also yielded air flows that were significantly higher than those obtained with the “standard” viscoelastic foam formulations that were prepared at the same isocyanate index. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44449.
Access Extensions for ANCP (2000)

The purpose of this document is to specify extensions to ANCP (Access
Node Control Protocol) (RFC6320) to support PON as described in
RFC6934 and some other DSL Technologies including G.fast. This
document updates RFC6320 by modifications to terminologies, flows and
specifying new TLV types. This document updates RFC6320 by
modifications to terminologies, flows and specifying new TLV types.
A General Procedure for the Esterification of Carboxylic Acids with Diazoalkanes Generated in situ by the Oxidation of N‐tert‐Butyldimethylsilylhydrazones with (Difluoroiodo)benzene. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Neoadjuvant therapy before radical prostatectomy for clinical T3/T4 carcinoma of the prostate: 5-year followup, Phase II Southwest Oncology Group Study 9109. (2002)

Neoadjuvant hormonal therapy followed by radical prostatectomy is reasonable and appropriate for clinical stage T3 prostate cancer. A progression-free and overall 5-year survival of 70% and 90%, respectively, compares favorably to Radiation Therapy Oncology Group neoadjuvant trial outcomes for this stage of prostate cancer.
AUTOMATIC METHODS TOWARD GENERATING DIGITAL TRUE ORTHOPHOTO BY USING DENSE LiDAR DATA (2008)

Technological developments of recent years in the digital photogrammetry field have facilitated generation of reliable digital orthophotos, required for various surveying and Geographic Information (GI) applications. These developments are driven by the demand for high resolution data for research and engineering projects – properties that digital orthophotos provide. The existing methods for generating digital orthophotos require interpretation of aerial photographs and using a Digital Terrain Model (DTM), correspondingly. Even though this process utilizes dense and accurate data, the final product is not always reliable, due to several limitations of the existing methods, such as double mapping, hidden areas and geometric distortions of objects (such as buildings), etc. which require further intervention. In recent years, Light Detection and Ranging (LiDAR) technology became a significant factor in producing up-to-date and accurate topographic data. This technology, based on airborne laser scanners, enables acquiring dense and accurate 3D data of the surveyed area, i.e., the Digital Surface Model (DSM). The research presented here is based on the advantages, accuracy and reliability of the LiDAR data in providing better solutions of problems and difficulties arising in the existing methods for generating digital orthophotos, thus affecting the quality of the final orthophoto product. In this paper we are introducing novel fully automatic procedures and algorithms employing LiDAR data to solve the problems noted above. This new technique is based on correct filtering and classification of the LiDAR data, and is thus able to generate a reliable digital orthophoto that accurately represents the processed area.
Methodological Approach for Analyzing the Impact of Chemical EOR on Surface Processes (2013)

Abstract One important aspect that is generally neglected in chemically-based enhanced recovery technology concerns the impact of the EOR chemicals on the produced water cycle. After the chemical breakthrough, part of the EOR chemicals will be recovered in the produced fluids and may strongly impact oil/water separation and water treatment surface processes. This paper describes a specific laboratory methodology designed to study the impact of ASP-type chemicals on produced fluids treatment efficiency and will highlight the impact of polymers and sulfonated EOR surfactants on oil/water separation and water treatment efficiency. The methodology consists in a first step in evaluating the risk of stable emulsion formation and assessing the impact of chemical EOR on separation efficiency. Produced fluids are formulated and characterized (different water cuts, type of agitation, EOR chemicals,…). The stability of the different emulsified systems is analyzed over time. Then the efficiency of separation of water-in-oil (w/o) emulsions is determined for the three main types of dehydration processes: gravity separation, chemical demulsification, electrical dehydration. The quality of the separated water is systematically reported. In a second step, impact of chemical EOR on produced water treatment efficiency is studied. Produced waters are formulated and characterized (different oil concentrations, simulated back produced EOR chemicals,…). Behavior of theses systems are then studied using here an induced gas flotation lab column and membrane filtration. Turbidity of the water and concentration of oil in water is monitored as a function of time to quantify the impact of the EOR chemicals on treatment efficiency. This methodology will be illustrated on a heavy oil in presence of EOR chemicals (HPAM, sulfonated surfactants). The results show that these chemicals can have a strong impact on surface processes. This work emphasises that water management is an important challenge for chemical EOR that needs an integrated approach and should be studied upfront.