gebhart/patrepeval huggingface dataset:
Subcellular Localization of the Receptor for Gonadotropin-Releasing Hormone in Pituitary and Ovarian Tissue* (1983)

The subcellular localization of GnRH receptors in weanling rat anterior pituitary and ovarian tissue was determined by radioligand binding in biochemically defined fractions prepared by differential and density centrifugation. Morphological identification of membrane organelles or fragments, visualized by electron microscopy, confirmed the biochemical characterization. The greatest amount of specific ligand binding in both tissues was measured in the crude membrane fraction, while small amounts were detected in other fractions. The distribution of pituitary binding sites in sucrose gradient subfractionation of crude membranes correlated with the distribution of plasma membrane (assessed by 5'-nucleotidase activity and electron microscopy), but not that of secretory granules (identified by immunoreactive LH) or lysosomes (acid phosphatase activity). These data suggest that the GnRH-binding sites detected by radioligand binding assay in pituitaries of rats not previously exposed to GnRH are localized almost exclusively in the plasma membrane fraction.
Reaction of α- and γ-Stilbazoles with Selenium Dioxide (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of α- and γ-Stilbazoles with Selenium DioxideC. A. Buehler, James O. Harris, and William F. ArendaleCite this: J. Am. Chem. Soc. 1950, 72, 11, 4953–4955Publication Date (Print):November 1, 1950Publication History Published online1 May 2002Published inissue 1 November 1950https://pubs.acs.org/doi/10.1021/ja01167a032https://doi.org/10.1021/ja01167a032research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Reconfigurable UWB MIMO Antenna for Indoor and Outdoor Communication Applications (2019)

This paper presents implementation and analysis of reconfigurable ultra-wideband (UWB) multiple-input multiple-output (MIMO) antenna system in indoor and outdoor communication scenarios. The proposed compact and reconfigurable UWB antenna system has operating frequency range from 440 MHz - 5 GHz. In indoor communication, based on the TGn-B propagation model, the MIMO system can achieve a maximum channel capacity of 26.97 bps/Hz. In outdoor communication, based on the Spatial Channel Model (SCM) - Suburban - Macro non-line of sight (NLOS), the MIMO system achieves a maximum channel capacity of 6.25 bps/Hz. It is demonstrated that orthogonal orientation of the reconfigurable UWB antenna in MIMO exhibits improved polarization diversity.
Fundamentals of new food product development (1988)

1. Introduction. The new food product. Convenience foods. The institutional and fast-food trade. The role of the food scientist. The food processor and the new product. Criteria for new products. The market. The consumer. Population and food consumption. The world market. 2. Basics of New Food Product Development. Idea stage. Development stage. Taste-paneling stage. Consumer sampling stage. Shelf life stage. Packaging stage. Production stage. Market-testing stage. Commercialization stage. 3. Food Constituents and Functionality. Proteins. Carbohydrates. Lipids. Water. 4. Ingredient Functions and Selection. What is a food additive? Acidulants. Antioxidants. Preservatives. Colors. Flavors. Enzymes. Stabilizers and thickeners. Nutritive agents. Surface-active agents. Miscellaneous additives. 5. Organoleptic Principles and Evaluation. Appearance. Flavor. Texture. 6. Quality Control and Quality Assurance. Parameters of quality. Food safety. Samples and sampling frequencies. Testing procedures. Control charts. Sanitation. Consumer satisfaction. Product withdrawal or recall. Quality motivation. 7. Food Preservation. Refrigeration. Freezing. Heat preservation. Dehydration. Food concentration. Intermediate moisture foods. Food fermentations. Food irradiation. 8. Packaging. Packaging materials and forms. Controlled- and modified-atmosphere packaging. Aseptic packaging. Retort pouch. Packaging regulations. 9. Marketing. Defining the consumer. Defining the marketplace. Defining corporate objectives. What constitutes a new product. New product concept testing. New product market-testing. New product pricing. Distribution. Advertising and promotion. 10. Trademarks, Patents and Labels. Patents. Labels. 11. Regulatory Aspects of Food Processing. United States Department of Agriculture. Food and drug administration. 12. Nutrition. Nutritional quality. Nutrition labeling. Labeling low-calorie foods. 13. New Products from Cornell: Eggs, Poultry, and Seafood. Egg products. Poultrymeat products. Seafood products. Frozen minced fish. Seafood crispies. Canned minced fish. Canned red hake and pollock. 14. Future Trends. Facts and trends affecting the food industry.
ACTR/AIB1 Functions as an E2F1 Coactivator To Promote Breast Cancer Cell Proliferation and Antiestrogen Resistance (2004)

Overexpression or amplification of ACTR (also named AIB1, RAC3, p/CIP, TRAM-1, and SRC-3), a member of the p160 family of coactivators for nuclear hormone receptors, has been frequently detected in multiple types of human tumors, including breast cancer. However, its role in cancer cell proliferation and the underlying mechanism are unclear. Here, we show that overexpression of ACTR not only enhances estrogen-stimulated cell proliferation but also, more strikingly, completely negates the cell cycle arrest effect by tamoxifen and pure antiestrogens. Unexpectedly, we found that ACTR directly interacts, through its N-terminal domain, with E2F1 and is recruited to E2F target gene promoters. Elevation of ACTR in quiescent cells strongly stimulates the transcription of a subset of E2F-responsive genes that are associated with the G(1)/S transition. We also demonstrated, by adenovirus vector-mediated RNA interference, that ACTR is required for E2F1-mediated gene expression and the proliferation of estrogen receptor (ER)-negative breast cancer cells. Moreover, the ability of elevated ACTR to promote estrogen-independent cell proliferation depends on the function of E2F1 and the association between ACTR and E2F1, but not ER. Thus, our results reveal an essential role of ACTR in control of breast cancer cell proliferation and implicate the ACTR-E2F1 pathway as a novel mechanism in antiestrogen resistance.
Are You Sure You Have a Good Model? (2006)

This chapter contains sections titled: Introduction Validation Methods: Different Answers Brought to Different Questions Software-related Validation Methods Ligand-based Pharmacophore Research Protein Structure-based Pharmacophore Research Critical Remarks Regarding Structure-based Pharmacophore Models Visual Inspection Consistency with Structure - Activity Relationships Some Limitations of Computer Programs Retained Chemical Features Spatial Arrangement 3D-QSAR Pharmacophore Models External Data to Back Up a Pharmacophore Model Biophysical Data Other Published Pharmacophore Models The “Test Set” Approach and the Kubinyi Paradox Database Mining Some Metrics to Assess Screening Performances The ROC Curve Approach A Successful Application: the Ultimate Validation Proof Validation of Pharmacophore Models for Virtual Screening Which Validation Method Should One Insist On? Validation of Pharmacophore Models to Guide Medicinal and Computational Chemistry Validation of Pharmacophore Models for Activity Prediction Which Validation Method Should One Insist On? Case Study: a New Pharmacophore Model for mGlu4R Agonists Metabotropic Glutamate Receptors as Potential Therapeutic Targets Pharmacology of Metabotropic Glutamate Receptor Subtype 4 (mGlu4) Training Set Elaboration Strategy for Perceiving the Pharmacophore Four Criteria to Validate our Pharmacophore Model Results of Our Pharmacophore Model Research with Catalyst-HypoGen and HypoRefine Description of the Two Retained Pharmacophore Models Hypothesis 1 (Catalyst-HypoRefine with Variable Weights) Hypothesis 2 (Catalyst-HypoRefine with Variable Weights and Tolerances) Comparison of the Two Retained Hypotheses Further Validation: Virtual Screening of the CAP Database Conclusion Acknowledgments References
MR hysterosalpingography in a rabbit model (1996)

Our objective was to evaluate the efficacy of MR imaging as compared with conventional hysterosalpingography (HSG) for the detection of fallopian tube patency after uterine injection of contrast material. Rabbit uterine horns (n= 18) were catheterized transvaginally. Five fallopian tubes were ligated and 11 were left unaltered. T1-weighted gradient-echo MR images were obtained before, during, and after injection of 1.0-3.0 mL of a dilute gadolinium-containing contrast agent. Corresponding conventional studies were performed with an equivalent volume of iohexol. Images were evaluated by two blinded readers. Observers agreed in all cases on the presence (n = 11) or absence (n = 5) of peritoneal spill with conventional HSG. Interpretation of MR HSG concurred with conventional HSG in 14 of 16 cases for each observer (P > .05). Reasons for misdiagnosis included small amounts of spill (n = 2), artifact (n = 1), and subtle spill between bowel loops (n = 1). Sensitivity and specificity for MR HSG were 95.5% and 70%, respectively, for the diagnosis of tubal patency/occlusions. No statistical difference was found between MR HSG and conventional HSG for the diagnosis of fallopian tube patency/obstruction. Potential advantages of MR HSG include no ionizing radiation, potentially diminished local contrast toxicity, superior visualization of uterine fibroids and endometriosis, and visualization of ovaries. We conclude that this technique warrants further study, including the use of a primate model to better simulate human anatomy.
Australian International Marimba Festival [invited solo recital and research presentor] (2008)

Performances included:Three Fantastic Songs: ZivkovicThe Source: IchiyanagiPrelude: BroughtonSeason: 29 September-2 October, 2008
K-mer-based host screening v2 (2016)

K-mer-based approaches to determining sequence similiarity can befaster than traditional use of BLAST. This application usesJellyfishto index host FASTA files, then uses the mode value (default 2)of the number of matching k-mers (default k=20) from the input sequenceto determine whether the sequence is similar enough to the host sequence to be rejected. The output of the app is: "screened" directory containing the sequences from each file that were found to be dissimlar to the host "rejected" directory containing the sequence from each file that were too similar to the host "jf" directory containing Jellyfish indexes of each "host" file (useful for later runs with other files to skip recreating) "kmer" directory containing k-mers of query sequences and ".loc" file showing the number of ".kmer" lines associated to each sequence Code is freely available atGithub.
Syndrome packets and health worker training improve sexually transmitted disease case management in rural South Africa: randomized controlled trial (2000)

A simple and affordable health service intervention achieved substantial improvements in STD case management. Although this is a critical component of STD control and can reduce HIV transmission, community-level interventions to influence health-seeking behaviour are also needed.
Effect of Exercise on Serum Estrogens in Postmenopausal Women (2004)

Elevated circulating estrogens and a sedentary lifestyle increase risk for breast cancer. The effect of exercise on circulating estrogens in sedentary postmenopausal women is unknown. The objective of this study was to examine the effects of a 12-month moderate-intensity exercise intervention on serum estrogens. We randomly assigned 173 sedentary, overweight (body mass index > 24.0 kg/m(2), body fat > 33%), postmenopausal women, ages 50-75 years, not using hormone therapy, living in the Seattle, Washington, area for the next year, and willing to be randomly assigned to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 days/week moderate intensity sports/recreational exercise). A total of 170 (98.3%) women completed the study with exercisers averaging 171 min/week of exercise. After 3 months, exercisers experienced declines in estrone, estradiol, and free estradiol of 3.8, 7.7, and 8.2%, respectively, versus no change or increased concentrations in controls (P = 0.03, 0.07, and 0.02, respectively). At 12 months, the direction of effect remained the same, although the differences were no longer statistically significant. The effect was limited to women who lost body fat: women whose percentage of body fat [by dual energy x-ray absortiometry (DEXA)] decreased by >/==" BORDER="0">2% had statistically significant (comparing exercisers versus controls) decreases at 12 months of 11.9, 13.7, and 16.7% for serum estrone, estradiol, and free estradiol, respectively. We concluded that a 12-month moderate-intensity exercise intervention in postmenopausal women resulted in significant decreases in serum estrogens. The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens.
Design, fabrication, back-to-back test of 14200-hp two-pole cylindrical-rotor synchronous motor for ASD application (1998)

This paper describes the design aspects, fabrication, and testing of a 14200-hp two-pole cylindrical-rotor synchronous motor used with a load-commutated inverter (LCI) adjustable-speed drive (ASD) to drive a refrigeration compressor for a refinery alkylation plant. The motor design aspects include extensive finite-difference analysis of the rotor cage assembly and laboratory bench testing of a wedge assembly to verify finite-difference analysis results prior to fabrication. Torsional and harmonic analysis results are also presented. Special considerations are discussed regarding rotor heating due to harmonic currents and mitigation methods for handling the harmonic currents and heating. Mechanical design aspects are presented of the rotor cage, including rotor slot design, wedge, and end ring assembly. Two motors and drives were built, for companion projects, allowing for verification of the rotor-cage assembly by a back-to-back (BTB) test. Test preparation, setup and results are presented, including rotor temperature mapping, vibration data and torsional results. Finally, test results are compared with calculated values.
Nuclear interferometry for two-nucleon systems (experiment E286 at GANIL) (1998)

International audience
ENDOPLASMIC RETICULUM MEDIATES MITOCHONDRIAL TRANSFER IN THE OSTEOCYTE DENDRITIC NETWORK (2018)

Osteocytes are terminally differentiated long-lived cells and account for greater than 95% of the bone cell population. It has been established that osteocytes are connected through their highly de...
Electric Field Formation during Combustion of Single Metal Particles (2003)

A strong electric field formed during the initial stage of the combustion of single Zr, Ti, Fe, and Ni particles. The electric field lasted for 20-400 ms and decayed before the particle temperature reached its maximum. A low voltage was generated during the combustion of particles initially surrounded by a thick oxide film or when the ambient oxygen concentration was low. A decrease in the rate of oxygen transport to the reaction zone generated a bipolar signal during the combustion of Zr and Ti and/or electric oscillations of 0.5-10 Hz. Melting of either the reactants, or intermediate or final products annihilated the electrical field. The maximum voltage and current were attained for particles of ∼0.8 mm diam. The largest unipolar electric voltage and current were produced during the combustion of either a Zr or a Ti particle (∼2 V and ∼100 mA). A rapid increase in the rate of temperature rise in Zr and Ti particles followed the annihilation of the electric field. It may have been caused by Joule heating following electric breakdown through the oxide film. A shift from homogeneous to relay-race combustion occurred upon increasing the distance between particles in a row. This shift affected the qualitative features of the generated electric field as well as the temperature at which it formed. © 2003 The Electrochemical Society. All rights reserved.
On the efficiency of local and global communication in modular robots (2009)

As exchange of information is essential to modular robots, deciding between local or global communication is a common design choice. This choice, however, still lacks theoretical support.
The Potential for Using Little Diomede Island as a Platform for Observing Environmental Conditions in Bering Strait (2009)

The Pacific waters that enter the Arctic via the Bering Strait exert a major influence on the Arctic Ocean’s stratification, ice cover, and ecosystem. We demonstrate the potential of a shore-based laboratory to monitor the water masses that flow predominantly northward past Little Diomede Island in the center of the Bering Strait into the Arctic Ocean. We determined near-surface water column salinity, inorganic nutrient concentrations, natural fluorescence associated with chlorophyll, and the oxygen isotope composition of seawater, both in summer during the open-water period and in late winter under ice-covered conditions, by pumping ashore water from shallow depths near the island. Additional surveys were undertaken within 5 km of the island to assess the influence of local sources of nutrients. Water mass variability was much greater during the open-water period than under ice-covered conditions, presumably because the relatively immobile ice cover attenuates wind forcing and the decrease in run-off reduces cross-shelf gradients. The mean oxygen isotope composition of the summer (?18O = -1.11‰) and late winter (?18O = -0.98) collections, however, was close to that which has been established for Bering Sea waters in the Pacific-dominated upper halocline of the Arctic Ocean (-1.1‰) particularly considering the higher seasonal flow of runoff in the summer. A comparison with data from shipboard sampling at various locations across the Bering Strait indicates that the oxygen isotope composition of near-surface water sampled at Diomede varies in response to wind-forcing. If the least saline (< 30.5) water near the Alaska coast is excluded, the ?18O values of Diomede and shipboard samples cannot be distinguished statistically. This similarity suggests that the water sampled from the island also reasonably represents the ?18O value of Bering Sea waters that contribute to the upper halocline of the Arctic Ocean. Effects of benthic recycling, human activity, and seabird nesting on nutrient concentrations appeared to be concentrated within ~200 m of the island. Our results are discussed in the practical context of availability of electricity, interested local residents, and a geotechnical study indicating that it is feasible to construct and operate a more permanent undersea water intake system to improve environmental observation capabilities in the Bering Strait region.
Structure/function studies of doxycycline effects on matrix metalloproteinase activity and cartilage degeneration (2001)

The observation that doxycycline and other tetracyclines reduced the level of matrix metalloproteinase (MMP) activity in periodontal disease, even in germ-free rats [1 2] prompted the testing of these compounds for treatment of osteoarthritis (OA) [3 4], rheumatoid arthritis (for extensive review of this topic see [5-9]) and other diseases in which MMP-mediated destruction of connective tissues is prominent, such as abdominal aortic aneurysms [10] and wound healing in diabetes [11]. Doxycycline and chemically modified tetracyclines have been tested in animal models of OA, a disease in which the degradation of joint connective tissues is thought to depend, at least partially, on MMP activity. In our laboratory, we have employed doxycycline to treat canine experimental OA. We have examined the effect of treatment with oral doxycycline on the MMP of tissues from patients with rheumatoid arthritis, see [5-9], and patients with OA at the time of joint replacement surgery [3]. Similar studies have been performed using minocycline for treatment of adjuvant arthritis in rats [12], and for chemically modified tetracycline-7 (cmt-7) in a spontaneous model of OA in Taft-Hartley guinea pigs [13]. The guinea pig model resembles human disease in that the development of OA is weight-and age-dependent. Treatment with doxycycline slowed disease progression in the animal models, while MMP activity was reduced in both animal and human tissues.
End-user software engineering (2004)

End-user programming has become the most common form of programming in use today [2], but there has been little investigation into the dependability of the programs end users create. This is problematic because the dependability of these programs can be very important; in some cases, errors in end-user programs, such as formula errors in spreadsheets, have cost millions of dollars. (For example, see www.theregister.co.uk/content/67/31298.html or panko.cba.hawaii.edu/ssr/Mypapers/whatknow.htm.) We have been investigating ways to address this problem by developing a software engineering paradigm viable for end-user programming, an approach we call end-user software engineering .
Design of compact dual-band dual-port WLAN MIMO antennas using slots (2015)

In this paper, a compact printed dual-band dual-port multiple-input multiple-output (MIMO) antenna operating in the 2.4-GHz (2.4-2.5 GHz) band of the IEEE802.11b/g standard and in the 5-GHz (4.9-5.1 GHz, 5.15-5.35 GHz, 5.47-5.725 GHz)band of the IEEE 802.11a with dual band decoupling elements is presented. Each dual-band antenna consists of a one quarter wavelength monopole slot and one half wavelength slot fed by microstip line. To reduce the mutual coupling and achieve high isolation between the two nearby dual-band antennas, we proposetwo narrow λ/4 slits on the ground plane. The simple decoupling slits not only reduce the coupling between antennas, but also improve the impedance bandwidth. Furthermore, the antenna has a compact structure and occupies a small area of 10×46 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and it is printed ona FR-4 printed-circuit-board. The proposed antennas are investigated by simulation and measurement.
Accounting for model uncertainty in estimating global burden of disease (2011)

Sampling variability explains only a portion of the overall uncertainty in a modelled estimate. The uncertainty owing to both the sampling variability and the choice of model(s) should be given when disease burden results are presented. Failure to properly account for uncertainty in disease burden estimates may lead to inappropriate uses of the estimates and inaccurate prioritization of global health needs.