gebhart/patrepeval huggingface dataset:
Interaction of amphotericin B and its selected derivatives with membranes: molecular modeling studies (2006)

Amphotericin B (AmB) is a well-known antifungal antibiotic that has been used in the clinic for about five decades. Despite its chemotherapeutic importance, AmB is quite toxic and many efforts have been made to improve its pharmacological properties, e.g., by chemical modifications. The lipid membrane is a molecular target for AmB, however, due to heterogeneity of its components, the molecular mechanism of AmB action is still unclear. The lack of this knowledge hinders rational designing of new and less toxic AmB derivatives. Our review is a critical presentation of the current understanding of AmB molecular mechanism of action at the membrane level. Except the experimental approach, the extensive overview of molecular modeling studies, performed mostly in our lab, is presented. The results of interactions between AmB or some of its derivatives and lipid model membranes are discussed. In our studies, different biomembrane models and different associate states of the antibiotic were included. Presented molecular modeling approach is especially valuable with regard to a new paradigm of the structure of lipid membrane containing liquid-ordered domains. Hopefully, all these complementary experimental/computational approaches are going to reach the point at which a new hypothesis about molecular mechanism of AmB activity and selectivity will be put forward.
FracBot: Design of wireless underground sensor networks for mapping hydraulic fractures and determining reservoir parameters in unconventional systems (2018)

Wireless underground sensor networks (WUSNs) enable a wide variety of\nemerging applications that are not possible with current underground monitoring techniques, which require miniaturized wireless sensor systems for mapping hydraulic fractures, monitoring unconventional reservoirs and measuring other wellbore parameters. We call these devices FracBots (Fracture Robots), an extension of RFID (Radio Frequency IDentifcation) tags that realize WUSNs for mapping and characterization of hydraulic fractures in unconventional reservoirs. The objective of this thesis is to design fully integrated magnetic induction (MI)-based FracBots (WUSNs) that enable reliable and e fficient wireless communications in underground oil reservoirs for performing the in-situ monitoring of oil reservoirs. This is very crucial for determining the sweet spot of oil and natural gas reserves. To this end, we have contributed in four areas as follows: fi rst, we develop a novel cross-layer communication framework for\nMI-based FracBot networks in dynamically changing underground environments. The framework combines a joint selection of modulation, channel coding, power control and a geographic forwarding paradigm. Second, we develop a novel MI-based localization framework that exploits the unique properties of MI- eld to determine the locations of the randomly deployed FracBot nodes in oil reservoirs. Third, we develop an accurate energy framework of a linear FracBot network topology that generates feasible nodes' transmission rates and network topology while always guaranteeing su fficient energy. Then, we design, develop, and fabricate MI-based FracBot nodes. Finally, to validate the performance of our solutions in our produced prototype of FracBot nodes, we develop a physical MI-based WUSN testbed.
Prognostic significance of pathological response after neoadjuvant chemotherapy or chemoradiation for locally advanced cervical carcinoma (2006)

Complete pathological response but no Near-complete and partial responses is associated with longer survival in cervical cancer patients treated with neoadjuvant chemotherapy or chemoradiotherapy.
Split and Rephrase: Better Evaluation and Stronger Baselines (2018)

Splitting and rephrasing a complex sentence into several shorter sentences that convey the same meaning is a challenging problem in NLP. We show that while vanilla seq2seq models can reach high scores on the proposed benchmark To aid this, we present a new train-development-test data split and neural models augmented with a copymechanism, outperforming the best reported baseline by 8.68 BLEU and fostering further progress on the task.
Implementation of Continuous Delivery Systems (2016)

Continuous Integration, Delivery, and Deployment are subjects that have been on the table in the recent years. The books Continuous Integration by Duvall et. al (2007), and Continuous Delivery by Humble et. al (2010) are, however, the only extensive literature that has been published on the subject. In addition to the books there is information available based on miscellaneous conferences and scientific publishments, but this information is fairly scattered and hard to compile.\nA lot of companies suffer from long delays between implementing and delivering software features. Multiple parties ranging from foreign developers to Finnish leader projects have researched the benefits that can be gained from automating and making software delivery continuous. Benefits include among other things rapid customer feedback, lowered production delivery costs and delays, and smaller number of errors in processes. \nCompanies do, however, have difficulties in implementing Continuous Integration, Delivery, and Deployment. This is mainly due to the arbitrarity of the work. There is information available on the subject, but collecting, studying, and distributing that information can be very costly. \nThis Master of Science thesis researches the implementation a Continuous Delivery system in a Finnish software company. The research work is done in an internal project, and the aim is to implement a generic software build, test, and delivery system. The process involves gathering business, technical, and user requirements, compiling a requirements definition, designing a phased project plan, and executing that plan to implement a Continuous Delivery system on top of the AWS cloud platform.
Scalable visualization resizing framework (2011)

Effective visualization resizing is important for many visualization tasks, where users may have display devices with different sizes and aspect ratios. Our recently designed framework can adapt a visualization to different displays by transforming the resizing problem into a non-linear optimization problem. However, it is not scalable to a large amount of dense information. Undesired cluttered results would be produced if dense information is presented in the target display. We present an extension to our resizing framework with a seamless integration of a sampling-based data abstraction mechanism, such that it is scalable with not only different display sizes, but also different amounts of information.
Ultrasound in materials chemistry (1996)

Ultrasound has applications in materials, organometallic, polymer and synthetic chemistry as well as materials and waste degradation. After a brief description of the fundamentals of sonochemistry, an overview about current uses and future prospects in these fields is given.
Ammonium/Methylammonium Permeases of a Cyanobacterium (1998)

Ammonium is an important nitrogen source for many microorganisms and plants. Ammonium transporters whose activity can be probed with [14C]methylammonium have been described in several organisms including some cyanobacteria, and amt genes encoding ammonium/methylammonium permeases have been recently identified in yeast, Arabidopsis thaliana, and some bacteria. The unicellular cyanobacterium Synechocystis sp. PCC 6803 exhibited a [14C]methylammonium uptake activity that was inhibited by externally added ammonium. Three putative amt genes that are found in the recently published complete sequence of the chromosome of strain PCC 6803 were inactivated by insertion of antibiotic resistance-encoding gene-cassettes. The corresponding mutant strains were impaired in uptake of [14C]methylammonium. Open reading frame sll0108 (amt1) was responsible for a high affinity uptake activity (Ks for methylammonium, 2.7 microM), whereas open reading frames sll1017 (amt2) and sll0537 (amt3) made minor contributions to uptake at low substrate concentrations. Expression of the three amt genes was higher in nitrogen-starved cells than in cells incubated in the presence of a source of nitrogen (either ammonium or nitrate), but amt1 was expressed at higher levels than the other two amt genes. Transcription of amt1 was found to take place from a promoter bearing the structure of the cyanobacterial promoters activated by the nitrogen control transcription factor, NtcA.
Implementation of a modern microprocessor based voltage quality recorder (2002)

This paper presents a low-cost solution for an instrument capable of recording most of the voltage anomalies that constitute poor quality of supply. The most common and severe power supply quality anomalies were implemented. Special attention is given to the hardware and embedded software of the instrument.
Treatment of chronic painful diabetic neuropathy with intravenous lidocaine infusion. (1986)

as distance) is decisive despite the regulations, which are couched as a series of alternatives.2 Decisions are made by lay officers interpreting a medical report which pays insufficient attention to assessment of mobility.3 This study therefore measured not only aspects of the mobility of holders of the allowance but also the collective opinions ofa group ofassessors. The results should interest organisations representing disabled people.4
"Injectable Silicones" (1965)

ONE of the most dramatic recent breakthroughs in surgery has been the varied uses to which silicones have been put. Most work has been centered around the silicone rubbers, because their inertness permits solution of certain mechanical and engineering problems in surgery; for example, drainage valves have been inserted in over 35,000 hydrocephalics, many patients have silicone heart valves, others have silicone jackets around intracranial aneurysms, and countless numbers have had scleral buckling procedures using silicone, to mention but a few of the applications. The rubbers are now so commonly used that they may be purchased from any medical supply house. Of late, more attention has been directed to use of liquid silicones—the state in which the materials first found medical adoption. An article detailing experiences with these substances will be found in this issue of theArchives. It is difficult not to become overenthusiastic when one has seen the
Special Feature: Instruction in MOS LSI Systems Design (1980)

Designers of next-generation computers will employ a building-block approach reflecting the interdependence of system architecture and IC design. This course prepares for that approach.
Further evidence of extrinsic forces in bending of the neural plate (1991)

Bending of the neural plate has long been considered to be driven by principally intrinsic forces generated by wedging of neurepithelial cells. Our previous studies have shown that during neural fold elevation, significant neurepithelial cell wedging occurs only within the median hinge point (MHP), the midline region of neural plate anchored to the notochord. We have also shown that neural fold elevation can still occur when MHP cells are prevented from becoming wedge-shaped but fails to occur when the neural plate is separated from lateral nonneurepithelial tissues, even though MHP cells still become wedge-shaped and the midline neural plate still furrows. Together, these results suggest that neural fold elevation, rather than being driven by neurepithelial cell wedging, is driven, at least in part, by extrinsic forces generated by lateral nonneurepithelial tissues. However, it could be argued that in the absence of localized neurepithelial cell wedging, compensatory and atypical cell wedging occurred uniformly throughout the neural plate, providing forces adequate for neural fold elevation. Likewise, it could be argued that in the process of separating the neural plate from lateral nonneurepithelial tissues, the neural plate was damaged to the extent that the neural folds were unable to elevate. To investigate the validity of these arguments, we removed the following tissues microsurgically prior to neural fold elevation: MHP cells, varying amounts of lateral neurepithelial cells (L cells), and the tissues directly underlying these two populations of neurepithelial cells. We found that the neural folds still formed and underwent elevation, convergence, and fusion, resulting in an essentially normal neural tube, even though MHP cells, the underlying notochord, and some L cells were absent for long craniocaudal distances. These results demonstrate that microsurgery alone does not damage the neural plate sufficiently to prevent neural fold elevation, convergence, and fusion. Moreover, the fact that each of the two persisting remnants of lateral neurepithelium generally remained straight and consistently changed their orientation from horizontal to vertical rather than curling suggests very strongly that bending of the neural plate in these embryos is not the result of compensatory and atypical cell wedging. Finally, the results provide further direct evidence of extrinsic forces in bending because the two remnants of lateral neurepithelium, which were oriented horizontally at the time of tissue extirpation, could not have become oriented vertically in the absence of such forces.
Regulation of ROMK Channel and K+ Homeostasis by Kidney-specific WNK1 Kinase (2009)

WNK kinases are serine-threonine kinases with an atypical placement of the catalytic lysine. WNK1, the first member discovered, has multiple alternatively spliced isoforms, including a ubiquitously expressed full-length long form (L-WNK1) and a kidney-specific form (KS-WNK1) predominantly expressed in the kidney. Intronic deletions of WNK1 that increase WNK1 transcript cause pseudohypoaldosteronism type 2, an autosomal-dominant disease characterized by hypertension and hyperkalemia. L-WNK1 inhibits renal K(+) channel ROMK, likely contributing to hyperkalemia in PHAII. Previously, we reported that KS-WNK1 by itself has no effect on ROMK1 but antagonizes L-WNK1-mediated inhibition of ROMK1. Amino acids 1-253 of KS-WNK1 (KS-WNK1(1-253)) are sufficient for reversing the inhibition of ROMK1 caused by L-WNK1(1-491). Here, we further investigated the mechanisms by which KS-WNK1 counteracts L-WNK1 regulation of ROMK1. We reported that two regions of KS-WNK1(1-253) are involved in the antagonism of L-WNK1; one includes the first 30 amino acids unique for KS-WNK1 encoded by the alternatively spliced initiating exon 4A, and the other is equivalent to the autoinhibitory domain (AID) of L-WNK1. Mutations of two phenylalanine residues known to be critical for autoinhibitory function of AID abolish the ability of the AID region of KS-WNK1 to antagonize L-WNK1. To examine the physiological role of KS-WNK1 in the regulation of renal K(+) secretion, we generated transgenic mice that overexpress amino acids 1-253 of KS-WNK1 under the control of a kidney-specific promoter. Transgenic mice have lower serum K(+) levels and higher urinary fractional excretion of K(+) compared with wild type littermates despite the same amount of daily urinary K(+) excretion. Moreover, transgenic mice (compared with wild type littermates) displayed a higher abundance of ROMK on the apical membrane of distal nephron. Thus, KS-WNK1 is an important physiological regulator of renal K(+) excretion, likely through its effects on the ROMK1 channel.
소득-자산의 다중격차 (2014)

이 글은 한국의 소득-자산 결합 분포의 특성을 국가 간 비교를 통해서 밝혀보는 데 있다. 최근 구축된 국가 간 비교가능한 자산 지표와 자료를 활용하여 분석한 결과, 한국의 경우 자산 분포에서 미국이나 스웨멘에 비해서 상대적으로 불평등도가 낮고 스페인이나 이태리 등 남유럽국가들과 유사한 자산분포 구조를 가지고 있는 것으로 나타났다. 연령별 자산분포에서도...
Modelo para armar: complejidad y perspectivas de la protesta social en Argentina reciente (2004)

espanolEl articulo expone una caracterizacion de los principales actores sociales en los ultimos anos de la decada del ’90 del siglo pasado en Argentina, los cuales se conectan con los acontecimientos de diciembre de 2001. El abordaje de esta problematica se plantea a partir de una aparente paradoja, a saber: de un lado, la complejidad de los actores protagonistas en lo que hace a sus demandas, identidades y formas organizacionales, que dificulta pensarlos como un movimiento social en sentido tradicional; del otro, el profundo impacto politico de sus intervenciones que han contribuido a cuestionar aspectos centrales del orden politico como los modos de representacion, los procesos de legitimacion y la funcion del estado como agente de integracion social. Se concluye que la recuperacion del poder humano se reorganiza como espacio publico en un mundo comun, en la que la deliberacion se muestra como una practica configurativa a traves de la cual el mundo adviene como realidad compartida. EnglishThis article presents a characterization of the main social actors in the late '90s during the last century in Argentina which are associated with the events of December 2001. This issue arises from an apparent paradox, that is, on the one hand, the complexity of the leading actors –their demands, identities and organizations- makes it difficult to think of them as a social movement in the traditional sense; on the other hand, the deep political impact of their interventions has contributed to question central political aspects such as the representation, the legitimization processes and the function of the State as an agent of social integration. Finally, it is stated that human power is reorganized as public space in the ordinary world, in which deliberation is shown as a practice through which the world emerges as shared reality. DeutschDer Artikel stellt eine Charakterisierung der wichtigsten sozialen Akteure der letzten Jahre des letzten Jahrhunderts in Argentinien vor, die mit den Ereignissen vom Dezember 2001 in Beziehung stehen. Diese Problematik wird ausgehend von einem scheinbaren Paradoxon entworfen: einerseits erschwert es die Komplexitat der Hauptakteure bezuglich ihrer Forderungen, Identitaten und Organisationsformen, sie als soziale Bewegung im traditionellen Sinn zu denken; andererseits hat die tiefgreifende politische Wirkung ihres Auftretens dazu beigetragen, zentrale Aspekte der politischen Ordnung, wie beispielsweise die Formen der Reprasentation, die Legitimierungsprozesse und die Funktion des Staates als Agent der sozialen Integration, in Frage zu stellen. Es wird abschliessend behauptet, dass die menschliche Macht als offentlicher Raum in der Alltagswelt wiedergewonnen und reorganisiert werden kann, innerhalb dessen sich die Beratungen als eine konfigurative Praxis erweisen, durch die die Welt zu einer geteilten gemeinschaftlichen Realitat wird.
Content-based retrieval of 3D models in distributed Web databases by visual shape information (2002)

Digital documents assembled from different components, like text, images, video, audio and 3D models, are supported today by many distributed applications. This paper presents a new approach to retrieving 3D models as part of digital documents using content-based image retrieval functionality. To find a 3D model best-fitting the user's query, shape information is extracted from the retrieved models and a score is generated by comparing shape images with the graphical user input. A distributed database environment with a WWW interface is presented and used as a generic implementation platform for this technique. The new retrieval method for 3D geometry is then described by extending the generic architecture in two steps, with a server-side module and an interactive client display. I outline how this method can be used for partial geometry downloading of 3D models in digital libraries.
Working Memory, Controlled Attention and Task Switching (2000)

Public Reporting burden for this collection of information is estimated to average 1 hour p searching existing data sources, gathering and maintaining the data needed, and complet regarding this burden estimates or any other aspect of this collection of information, incluu."b --«,--nnnno
Tregs: Where We Are and What Comes Next? (2017)

Regulatory T cells are usually recognized as a specialized subset of CD4<sup>+</sup> T cells functioning in establishment and maintenance of immune tolerance. Meanwhile, there is emerging evidence that regulatory T cells (Tregs) are also present in various non-lymphoid tissues, and that they have unique phenotypes credited with activities distinct from regulatory function. Their development and function have been described in plenty of manuscripts in the past two decades. However, with the deepening of research in recent years, emerging evidence revealed some novel mechanisms about how Tregs exert their activities. First, we discuss the expanding family of regulatory lymphocytes briefly and then, try to interpret how fork-head box P3 (Foxp3), a master regulator of the regulatory pathway in the development and function of regulatory T cells, functions. Subsequently, another part of our focus is varieties of tissue Tregs. Next, we primarily discuss recent research on how Tregs work and their faceted functions in terms of soluble mediators, functional proteins, and inhibitory receptors. In particular, unless otherwise noted, the term "Treg" is used here to refer specially to the "CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+"</sup> regulatory cells.
Almost complete dehulling of high oil sunflower seed (1984)

Abstract An almost complete dehulling (hull residue lower than 3%) of sunflower seeds, before oil extraction, reduces to a minimum both the transfer of pigments from hulls to the flour and the content of fiber in the finished product. In this paper some results of our work on the dehulling of high‐oil seeds with an air‐jet impact huller are presented. The effectiveness of dehulling has been evaluated as a function of characteristics of the seed (variety, moisture and so forth) and of operative parameters (impact velocity, etc.). The optical analysis of the impact of the seeds on the target was made optical analysis of the impact of the seeds on the target was made by means of high‐speed cinematography (about 8000 frames/sec) to have a better view of the phenomenon and to measure the parameters of energy involved. The use of proper seed monentum, which is a function of the characteristic of the seed, can allow selective hull breaking with minimum kernel breakage. Almost complete hull‐free kernels from high‐oil sunflower seeds were obtained by means of a continuous dehuller‐separator pilot plant.
A Method of Multi-Radio Transmission Diversity with Packet Level Forward Error Correction (2009)

For heterogeneous networks,a method of multi-radio transmission diversity is proposed in order to exploit the multi-radio access diversity gain.The packet level forward error correction(FEC) is integrated with multi-radio transmission at sender.In order to exploit the considerable multi-radio transmission diversity(MRTD) gain and provide the efficiency of system throughput, the coded packet is adaptively allocated to each available radio access according to minimizing the probability of irrecoverable loss at receiver.The analysis and simulation on its performance are proven that the proposed scheme has optimal transmission reliability and efficiency especially in the terrible channel condition.
Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus (2012)

The consumption of symbiotic shake resulted in a significant increase in HDL and a significant decrease of glycemia.