gebhart/patrepeval huggingface dataset:
Dissolution kinetics of pyrochlore ceramics for the disposition of plutonium (2006)

Single-pass β ow-through (SPFT) experiments were conducted on a set of non-radioactive Ti-based ceramics at 90 °C and pH = 2 to 12. The specimens contained 27.9 to 35.8 wt%CeO2 as a surrogate for UO2 and PuO2. Compositions were formulated as TiO2-saturated pyrochlore (CeP1) and pyrochlorerich baseline (CePB1) ceramic waste forms. Pyrochlore + Hf-rutile and pyrochlore + perovskite + Hf-rutile constituted the major phases in the CeP1 and CePB1 ceramics, respectively. Results from dissolution experiments between pH = 2 to 12 indicate a shallow pH-dependence with an ill-defined minimum. Element release rates determined from experiments over a range of sample surface areas (S) and β ow rates (q) indicate that dissolution rates become independent of q/S values at 10.8 to 10.7 m/s. Dissolution rates dropped sharply at lower values of q/S, indicating rates that are subject to solution saturation effects as dissolved constituents become concentrated. Forward dissolution rates were 1.3(0.30) x 10-3 and 5.5(1.3) x 10-3 g/m2·d for CeP1 and CePB1 ceramics, respectively. Dissolution rates obtained in other laboratories compare well to the findings of this study, once the rate data are placed in the context of solution saturation state. These results make progress toward an evaluation of CeO2 as a surrogate for UO2 and PuO2 as well as establishing a baseline for comparison with radiation- damaged specimens.
Analysis of elastohydrodynamic lubrication in McKee—Farrar metal-on-metal hip joint replacement (2004)

An elastohydrodynamic lubrication (EHL) analysis was carried out in this study for a typical McKee-Farrar metal-on-metal hip prosthesis under a simple steady state rotation. The finite element method was used initially to investigate the effect of the cement and bone on the predicted contact pressure distribution between the two articulating surfaces under dry conditions, and subsequently to determine the elastic deformation of both the femoral and the acetabular components required for the lubrication analysis. Both Reynolds equation and the elasticity equation were coupled and solved numerically using the finite difference method. Important features in reducing contact stresses and promoting fluid-film lubrication associated with the McKee-Farrar metal-on-metal hip implant were identified as the large femoral head and the thin acetabular cup. For the typical McKee-Farrar metal-on-metal hip prosthesis considered under typical walking conditions, an increase in the femoral head radius from 14 to 17.4 mm (for a fixed radial clearance of 79 microm) was shown to result in a 25 per cent decrease in the maximum dry contact pressure and a 60 per cent increase in the predicted minimum film thickness. Furthermore, the predicted maximum contact pressure considering both the cement and the bone was found to be decreased by about 80 per cent, while the minimum film thickness was predicted to be increased by 50 per cent. Despite a significant increase in the predicted minimum lubricating film thickness due to the large femoral head and the thin acetabular cup, a mixed lubrication regime was predicted for the McKee-Farrar metal-on-metal hip implant under estimated in vivo steady state walking conditions, depending on the surface roughness of the bearing surfaces. This clearly demonstrated the important influences of the material, design and manufacturing parameters on the tribological performance of these hard-on-hard hip prostheses. Furthermore, in the present contact mechanics analysis, the significant increase in the elasticity due to the relatively thin acetabular cup was not found to cause equatorial contact and gripping of the ball.
RELATIONSHIP OF HHV8 REPLICATION AND KAPOSI'S SARCOMA AFTER SOLID ORGAN TRANSPLANTATION (1999)

HHV8 DNA sequences have recently been isolated from all types of Kaposi's sarcomas, and its association in the etiopathogenesis of this tumor has been established. However, little is known about the regulation of HHV8 replication in immunocompromised patients seropositive for this virus, and its impact on the development of Kaposi's sarcoma (KS). Through the study of a heart transplant patient who developed KS and in whom peripheral blood lymphocytes (PBLs) had been prospectively collected before and after transplantation, we have investigated the pathogenesis of HHV8. Our results indicate that (i) HHV8 can reactivate soon after transplantation; (ii) viral replication, as determined by quantification of HHV8 DNA load of PBLs, increases significantly after transplantation; and (iii) increased HHV8 DNA levels in PBLs are associated with the development of KS.
Signaling by ALK5 mediates TGF-β-induced ET-1 expression in endothelial cells: a role for migration and proliferation (2007)

Endothelin-1 (ET-1) is a potent endothelial-derived 21-amino-acid vasoconstrictor peptide and its expression is potently regulated by the cytokine transforming growth factor-β (TGF-β). Most cell types contain a TGF-β type I receptor form known as activin receptor-like kinase 5 (ALK5). However, endothelial cells coexpress an additional type I receptor named ALK1. These forms do not constitute redundant receptors with the same function, but they activate different Smad-mediated expression programmes leading to specific endothelial phenotypes. The aim of our study was to characterize the TGF-β-induced pathway leading to ET-1 expression in endothelial cells and the contribution of the TGF-β-mediated enhancement of ET-1 to the regulation of the endothelial cell migration and proliferation capacity. Our experiments indicate that TGF-β induces ET-1 expression preferentially through the ALK5/Smad3 pathway. Specific ALK5 inhibition totally blocked the anti-angiogenic effect of TGF-β. Antagonism of ET receptors partially reverted the effect of TGF-β, indicating that a significant portion of the anti-migratory and anti-proliferative actions of this cytokine is mediated by ET-1 acting in an autocrine manner on endothelial cells.
Proteins of Human Immunodeficiency Virus that Cross-React with Human 'Self' Antigens (1991)

rPuicPO~t"n9 bjrdei f or that collection of informattionl ii eatmted to 4vftf9C 1 houJr respon~se, includin
Power Inductors in Ceramic Multilayer Circuit Boards (2008)

Power electronic inductors, with values of several μH, have been integrated into thermally stable ceramic multilayer circuit boards by the use of NiZnCu and MnZn ferrite tapes in low temperature cofired ceramic (LTCC) technology. These ferrites are particularly attractive for switched mode power supplies in automation, drives, and consumer applications, where the miniaturization of modules is triggered by advances in transistor technology and switching frequencies. The small signal analysis of embedded individual inductors and coupled transformer coils reveals the generic design rules for these components and additional materials properties beyond those accessible by ring core measurements. In the process of adapting the materials to LTCC, the distinct differences between the two materials become blurred, for example, they can be engineered to exhibit similar cutoff frequencies. NiZnCu ferrite, which is sinterable in air, may even achieve higher permeability than MnZn ferrite. The latter, however, shows higher saturation flux density and current capacity of buried inductors for power line filters. The coupled inductor design in a transformer is particularly ruled by the shunt capacitance inside the coils and by the fact that Maxwell equations preclude strong magnetic coupling between ferrite-embedded conductor lines. While parasitic capacitances remain tolerable for standard dielectric layer material up to several MHz, the need for magnetic coupling requires a fabrication process for magnetic vias.
Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer (2018)

The link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism, is upregulated during both inflammation and cancer. COX-2 is induced by pro-inflammatory cytokines at the site of inflammation and enhanced COX-2-induced synthesis of prostaglandins stimulates cancer cell proliferation, promotes angiogenesis, inhibits apoptosis, and increases metastatic potential. As a result, COX-2 inhibitors are a subject of intense research interest toward potential clinical applications. Epidemiological studies highlight the potential benefits of diets rich in phytonutrients for cancer prevention. Plants contain numerous phytonutrient secondary metabolites shown to modulate COX-2. Studies have shown that these metabolites, some of which are used in traditional medicine, can reduce inflammation and carcinogenesis. This review describes the molecular mechanisms by which phytonutrients modulate inflammation, including studies of carotenoids, phenolic compounds, and fatty acids targeting various inflammation-related molecules and pathways associated with cancer. Examples of pathways include those of COX-2, mitogen-activated protein kinase kinase kinase, mitogen-activated protein kinase, pro-inflammatory cytokines, and transcription factors like nuclear factor kappa B. Such phytonutrient modulation of COX-2 and inflammation continue to be explored for applications in the prevention and treatment of cancer.
Explicit extrapolation operator synthesis for 2D and 3D migration using the Remez algorithm (1992)

Abstract In F-X explicit depth migration schemes; wavefield downward extrapolation is carried out through spatial convolution using symmetrical finite-length filters .
Molecular Properties and Transformations of Glycogen Phosphorylase in Animal Tissues (1962)

This chapter contains sections titled: Introduction Rabbit Skeletal Muscle Phosphorylases b and a Other Muscle Phosphorylases Interconversion of Skeletal Muscle Phosphorylases b and a Liver Phosphorylase Role of Phosphorylase in the Regulation of Glycogenolysis Conclusions
Primary Pulmonary MALT Lymphoma: Clinical Characteristics and Treatment Outcomes – Single Institution Experience (2010)

Abstract Abstract 4168 Background: Primary Pulmonary MALT lymphoma represents 15–20% of Extranodal Marginal Zone Lymphomas of Mucosa Associated Lymphoid Tissue (MALT). In contrast to the more common gastric MALT lymphoma, natural history, prognosis and treatment outcomes for primary pulmonary MALT lymphoma are not well defined. Herein, we report a single institution experience. Methods: Consecutive patients with primary pulmonary MALT lymphoma registered in the Mayo Clinic Lymphoma Database, which includes all consenting patients with lymphoma seen at Mayo Clinic Rochester, were reviewed for clinical features, treatment outcome progression free survival (PFS) and overall survival (OS). The pathology for all patients was centrally reviewed by hematopathologist and the diagnoses were based on WHO lymphoma classification criteria. PFS and OS were assessed using the Kaplan–Meier method and the Cox proportional hazard model was used to assess the impact of variables on PFS and OS. Results: Between December 1986 and June of 2009, ninety-seven patients with primary pulmonary MALT lymphoma were enrolled. The median age at diagnosis was 63 years (range 31–87). There were 43 (44%) males. The initial presentation was a unilateral pulmonary lesion (n=47, 48%), bilateral pulmonary lesions (n=41, 42%), and pulmonary lesion with intrathoracic lymphadenopathy (n= 4, 4%). Bone marrow involvement and presence of B symptoms were 4, 4% and 5, 5%, respectively. International Prognostic Index (IPI) was 0–1, 2–3 and 4–5 in 69, 25 and 1 patient(s) respectively. The median follow-up was 10.4 years. The estimated median OS was 13. 6 years and the median PFS was 5.5 years (Figure). In a multivariate analysis, age >60 (p=0.02) and ECOG PS>2 (p=0.01) were associated with shortened survival. The IPI and age adjusted IPI were not predictive of overall survival. The treatment outcomes for the most common treatment modalities are summarized in the Table below. The median PFS of the 38% of patients who had a complete surgical resection was excellent at 11.2 years; whereas for observed patients with residual disease after biopsy was 3.2 years. Only 8 patients received single agent rituximan with relatively low response rate. Summary: The prognosis of primary pulmonary MALT lymphoma is favorable, with a median survival of over 13 years. In patients with resectable disease, surgery alone is associated with excellent disease control. Further prospective studies are needed to define the optimal treatment of primary pulmonary MALT lymphoma. Disclosures: No relevant conflicts of interest to declare.
Eobody : A Follow-Up To Atomic Pro'S Technology (2003)

Ircam has been deeply involved into gesture analysis and sensingfor about four years now, as several artistic projects demonstrate.Ircam has often been solicited for sharing software and hardwaretools for gesture sensing, especially devices for the acquisition andconversion of sensor data, such as the AtoMIC Pro [1][2]. Thisdemo-paper describes the recent design of a new sensor to MIDIinterface called EoBody1
Process Development and Scale-up Optimization of the SARS-CoV-2 Receptor Binding Domain-Based Vaccine Candidate, RBD219-N1C1 (2020)

Abstract A SARS-CoV-2 RBD219-N1C1 (RBD219-N1C1) recombinant protein antigen formulated on Alhydrogel ® has recently been shown to elicit a robust neutralizing antibody response against SARS-CoV-2 pseudovirus in mice. The antigen has been produced under current good manufacturing practices (cGMP) and is now in clinical testing. Here, we report on process development and scale-up optimization for upstream fermentation and downstream purification of the antigen. This includes production at the 1 and 5 L scale in the yeast, Pichia pastoris, and the comparison of three different chromatographic purification methods. This culminated in the selection of a process to produce RBD219-N1C1 with a yield of >400 mg per liter of fermentation with >92% purity and >39% target product recovery after purification. In addition, we show the results from analytical studies, including SEC-HPLC, DLS, and an ACE2 receptor binding assay that were performed to characterize the purified proteins to select the best purification process. Finally, we propose an optimized upstream fermentation and downstream purification process that generates quality RBD219-N1C1 protein antigen and is fully scalable at a low cost.
SPRAY SYNTHESIS OF SUPERPLASTIC MATERIALS FOR NEAR-NET-SHAPE MANUFACTURING (1997)

Spray deposition was used to synthesize 5083 Al alloy with N2 and N2 + O2 mixture as atomization gases. The starting 5083 Al was alloyed with Zr during spray deposition in order to refine grain size. It was noted that the grains that were present in as-spray deposited 5083 Al were equiaxed. In the inert gas spray deposited alloys, grain size decreased with increasing Zr content. Reactive spray deposition using N2 + O2 mixture, however, led to an increase in average grain size which is considered a result of release of enthalpy during oxidation reaction of matrix alloys. The spray deposited alloys were thermomechanically processed using extrusion and multiple-pass warm rolling to further reduce grain size. Superplasticity was observed in the 500−550 °C temperature range for strain rates between 3 × 10−5 and 3 × 10−3 s−1. A maximum elongation of 465% was noted at 550% and 3 × 10−5 s−1. The spray deposited alloys thermomechanically processed by direct rolling, exhibited superplasticity in the same temperature and strain rate ranges as those for the extruded and rolled materials. The superplastic elongation of the spray formed and rolled material was relatively low, being in the range of 180 ∼ 260%.
Stability of thin-shell structures and imperfection sensitivity analysis with the Asymptotic Numerical Method (2002)

This paper is concerned with stability behaviour and imperfection sensitivity of thin elastic shells. The aim is to determine the reduction of the critical buckling load as a function of the imperfection amplitude. For this purpose, the direct calculation of the so-called fold line connecting all the limit points of the equilibrium branches when the imperfection varies is performed. This fold line is the solution of an extended system demanding the criticality of the equilibrium. The Asymptotic Numerical Method is used as an alternative to Newton-like incremental-iterative procedures for solving this extended system. It results in a very robust and efficient path-following algorithm that takes the singularity of the tangent stiffness matrix into account. Two specific types of imperfections are detailed and several numerical examples are discussed.
Altered regulation of protein disulfide isomerase in cells resistant to the growth-inhibitory effects of transforming growth factor beta 1. (1990)

A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness. Cells that were resistant to the growth-inhibitory effects of TGF beta 1 (KCR cells) were derived from K-ras-transformed BALB/MK keratinocytes (KC cells). Using a subtractive hybridization procedure with KC and KCR mRNAs, we isolated a complementary DNA clone for murine protein disulfide isomerase (PDI). The mRNA for PDI is inhibited by TGF beta 1 treatment in the parental KC cells, but not in the TGF beta 1-resistant KCR cells. Similar PDI down-regulation also occurs in other TGF beta-sensitive cells, but not in a human pancreatic carcinoma cell line which is insensitive to the growth-inhibitory effects of TGF beta 1. The results suggest that misregulation of PDI, an important component of co- and posttranslational modification systems, may be involved in the mechanism by which some cells escape from the growth-inhibitory effects of TGF beta 1.
Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib–dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study (2017)

Olaptesed pegol (olaptesed, NOX-A12) is a pegylated l-oligoribonucleotide that binds and neutralizes CXCL12, a chemokine which signals through CXCR4 and CXCR7 regulating a variety of processes during multiple myeloma (MM) development.1 CXCL12 inhibition reduces the myeloma-supportive activity of the bone marrow microenvironment and mobilizes myeloma cells to the circulation.2 In addition, CXCL12α levels were reported to correlate with osteolytic bone lesions and with increased bone marrow angiogenesis.3 Targeting CXCL12, therefore, is a promising strategy for disrupting myeloma-stroma interactions and inhibiting myeloma growth and survival. Here, we report pharmacokinetic, pharmacodynamic, safety and efficacy data of olaptesed in patients with relapsed/refractory MM and present data on baseline CXCL12α levels in this patient cohort. This first-in-patient Phase IIa study aims to translate the novel concept of combining proteasome and CXCL12 inhibition into the clinic and builds on a preclinical proof-of-concept regarding the significance of CXCL12 blockade in MM2 and on Phase I data in healthy subjects.4 Combining CXCL12 inhibition with bortezomib and dexamethasone (VD) was investigated in 28 patients with relapsed/refractory MM, who were either bortezomib-naive or considered not refractory to bortezomib. The median number of prior lines of therapy was 2 (range: 1–5), 39 and 14% of the patients presented with 3 or 4 prior lines, respectively. Cytogenetics were tested in 21 patients and high risk features were found in 36% of them. 54% of patients had prior treatment with bortezomib, 39% had a prior stem cell transplant and 57% were refractory to prior treatment. Further details on patient characteristics (Supplementary Table S1) and inclusion and exclusion criteria are available in the Supplementary Information. In the pilot phase, three cohorts of three patients each (four patients in the 1 mg/kg cohort due to patient replacement) were administered single doses of 1, 2 or 4 mg/kg of olaptesed alone by slow intravenous bolus injection 2 weeks prior to starting the combination treatment. Combination treatment was administered for eight cycles of 21 days. An intra-patient escalation was applied for safety reasons as olaptesed was combined for the first time with VD in cancer patients. Olaptesed was given 1–2 h prior to bortezomib at doses of 1 mg/kg in cycle 1, 2 mg/kg in cycle 2 and 4 mg/kg in cycles 3–8. Bortezomib was given on days 1, 4, 8 and 11 of each 21-day treatment cycle as intravenous injection of 1.3 mg/m2. Oral dexamethasone (20 mg) was added on the day of and the day after bortezomib administration. An outline of the study and details of patients’ flow are given in Supplementary Figures S1 and S2.
Speckle Noise Suppression in Fresnel Incoherent Correlation Holography (2010)

A motionless method of speckle noise suppression improves the resolution of the best in-focus images reconstructed from digital holograms. We average several independent incoherent digital holograms of the same scene, each of which is a superposition of three digital phase-shifted recorded holograms.
177: The “Side-Population” in Human Lymphoma Cell Lines have Increased Chemo-Resistance, Stem-Like Properties, as a Target for Immunotherapy (2008)

We previously demonstrated that cancer cells contain a distinct “side-population” (SP), characterized by active transport of Hoechst fluorescent dye. The mechanisms responsible for Hoechst efflux also contribute to resistance to chemotherapy. This population has been shown to be enriched for tumor initiating cells in several human cancer models. We hypothesize that targeting the cancer “SP” cells using immunotherapy will eliminate the cell population least sensitive to chemotherapy and enriched for tumor repopulating potential which may prevent relapse. In this study we characterize SP cells in ten Human Lymphoma Cell Lines. We show that that 5 of the 10 lymphoma cell lines tested (HDLM2, L428, Ramos, Toledo, Karpas) had a distinct SP ranging from 0.8–2%. In vitro these SP cells can repopulate both the SP and non-SP cells. Gene expression analysis of the SP showed increased expression of ABCG2 and other ABC transporters that mediate both the transport of Hoechst dye and other drugs including some chemotherapeutic agents out of the cell. Further, we demonstrated that cell lines with a SP are resistant to the chemotherapeutic drug gemcitabine, and within these lines it the SP cells that are preferentially resistant to this agent. The cell lines that did not have SP showed either complete or partial sensitivity to this drug. In addition, we demonstrated that the SP population is enriched for the cancer testis antigen's MAGE-4, SSX2 and NY-ESO. These antigens are attractive targets for cytotoxic T lymphocyte therapy since: they are immunogenic, have restricted expression in normal tissues, and are expressed in many cancers. These tumor antigens may render SP cells susceptible to T cell mediated destruction indicating that T cell therapy may have a powerful effect on drug resistant tumor cells when used as adjunct therapy.
In-Network PCA and Anomaly Detection (2007)

We consider the problem of network anomaly detection in large distributed systems. In this setting, Principal Component Analysis (PCA) has been proposed as a method for discovering anomalies by continuously tracking the projection of the data onto a residual subspace. This method was shown to work well empirically in highly aggregated networks, that is, those with a limited number of large nodes and at coarse time scales. This approach, however, has scalability limitations. To overcome these limitations, we develop a PCA-based anomaly detector in which adaptive local data filters send to a coordinator just enough data to enable accurate global detection. Our method is based on a stochastic matrix perturbation analysis that characterizes the tradeoff between the accuracy of anomaly detection and the amount of data communicated over the network.