gebhart/patrepeval huggingface dataset:
Rosiglitazone, an Agonist of PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>γ</mml:mi></mml:math>, Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2 (2007)

PPARgamma ligands inhibit the proliferation of non-small cell lung carcinoma (NSCLC) cells in vitro. The mechanisms responsible for this effect remain incompletely elucidated, but PPARgamma ligands appear to inhibit the mammalian target of rapamycin (mTOR) pathway. We set out to test the hypothesis that PPARgamma ligands activate tuberous sclerosis complex-2 (TSC2), a tumor suppressor gene that inhibits mTOR signaling. We found that the PPARgamma ligand rosiglitazone stimulated the phosphorylation of TSC2 at serine-1254, but not threonine-1462. However, an antagonist of PPARgamma and PPARgamma siRNA did not inhibit these effects. Rosiglitazone also increased the phosphorylation of p38 MAPK, but inhibitors of p38 MAPK and its downstream signal MK2 had no effect on rosiglitazone-induced activation of TSC2. Activation of TSC2 resulted in downregulation of phosphorylated p70S6K, a downstream target of mTOR. A TSC2 siRNA induced p70S6K phosphorylation at baseline and inhibited p70S6K downregulation by rosiglitazone. When compared to a control siRNA in a thymidine incorporation assay, the TSC2 siRNA reduced the growth inhibitory effect of rosiglitazone by fifty percent. These observations suggest that rosiglitazone inhibits NSCLC growth partially through phosphorylation of TSC2 via PPARgamma-independent pathways.
A method for the automated Raman spectra acquisition (2017)

Raman spectroscopy is a very powerful analytical technique with an increasing acceptance in the scientific community. For the optimization of the Raman acquisition, two main parameters, the integration time and the number of accumulations, need to be adjusted to the sample under analysis, as the sample, or even different spots on the same sample, can provide very different Raman responses one from another. In this paper, we present a suite of algorithms to automate the acquisition parameter adjustment to the sample under analysis, addressing issues such as spectral saturation, fluorescence, cosmic ray detection and removal, and adjustment of the acquisition parameters to optimize the acquired spectral data. This suite has been developed in the framework of the Raman Laser Spectrometer (RLS) instrument development for the Exomars mission but can be applied to any Raman spectrometer. This will allow the spectrometer to adapt to the characteristics of the sample that is being analyzed, optimizing the total operative time, while improving the usability and overall efficiency of the system. Copyright © 2017 John Wiley & Sons, Ltd.
New Prebiotics to Ameliorate High-Fat Diet-Induced Obesity and Diabetes via Modulation of Microbiome-Gut-Brain Axis (2018)

Role of gut microbiome in obesity and diabetes became apparent from several independent studies, indicating that gut microbiome modulators like prebiotics may improve microbiome perturbations (dysbiosis) to ameliorate metabolic derangements. We isolated water soluble, non-digestible polysaccharides from 5 foods (acorn, quinoa, sunflower, pumpkin and sago seeds) and assessed their impact on amelioration of high fat diet (HFD)-induced obesity and diabetes in mice and human microbiome using fecal slurry culture model. During isolation, purification, biochemical and digestion resistance characterization, and fermentation pattern by human fecal microbiome, we selected acorn and sago derived prebiotics, on the basis of purity, protein contamination and yield. All prebiotics increased short chain fatty acid (SCFA) production along with enhanced microbial diversity. Feeding of acorn and sago derived prebiotics supplemented HFD (5%) for 8 weeks, significantly reduced diet induced glucose intolerance and insulin resistance, without affecting adiposity. Beneficial effects of acorn and sago derived prebiotics were superior than inulin-feeding. Feeding of both prebiotics and inulin increased diversity of gut microbiome and enhanced SCFA production into the mice gut. Metabolic function was positively correlated with increased food conversion ratio indicating enhanced whole body metabolic rate by prebiotic feeding. Gastrointestinal motility was enhanced without changing food intake, after probiotic intervention. Hypothalamic energy signaling in terms of increased pro-opiomelanocortin and decreased agouti-related peptide and neuropeptide Y expression, was modulated by prebiotics administration. These results indicate that newly isolated prebiotics ameliorate HFD-induced defects of glucose metabolism via modulating microbiome-gut-brain axis, and can be used to prevent/treat diet induced obesity and diabetes. Disclosure S. Ahmadi: None. R.K. Nagpal: None. S. Wang: None. H. Yadav: None.
Survey Paper—Airline Yield Management An Overview of Seat Inventory Control (1987)

The seat inventory control component of airline yield management is examined, with an emphasis on the practical aspects of the problem. A survey of current airline practice indicates that seat inventory control is dependent on human judgment rather than systematic analysis. Past work on the development of mathematical methods in this area has focused on large-scale optimization models and simplified representations of the problem. There remains a need for practical solution approaches that incorporate quantitative decision tools.
Work in progress (1970)

article Free Access Share on Work in progress Author: N. Elliott View Profile Authors Info & Claims ACM SIGSOC BulletinVolume 2Issue 1May 1970pp 6–17https://doi.org/10.1145/1198288.1198289Published:01 May 1970Publication History 0citation81DownloadsMetricsTotal Citations0Total Downloads81Last 12 Months11Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
New Jersey’s Rapid Inspection Procedures for Vehicular Emissions (1968)

<div class="htmlview paragraph">In support of the Federal regulations which limit hydrocarbons and carbon monoxide emissions from new motor vehicles, the State of New Jersey has passed a law which is intended to require that vehicles with these controls, as well as vehicles without controls, be kept functioning properly. The law states that all motor vehicles subject to inspection pass a test annually to show compliance with standards to be set by the Department of Health.</div> <div class="htmlview paragraph">This paper describes the development of a 1 minute test for measuring and evaluating the crankcase and exhaust emissions for carbon monoxide, hydrocarbons, and smoke. It involves putting the vehicle on a simple set of inertia rolls and driving a simple cycle, called the ACID cycle, that was developed for this test. The exhaust is collected by either a variable dilution or variable flow system and analyzed for hydrocarbons, carbon monoxide, and carbon dioxide. The results will automatically be weighted, corrected, and compared with a standard to give a pass or fail answer.</div>
Effect of processing on the antinutrient content of rapeseed (1986)

Abstract The effects of dry extrusion of mixtures of rapeseed and soya bean on total and individual glucosinolates, selected glucosinolate hydrolysis products, myrosinase, sinapine and tannins have been compared with those of more conventional processing, e.g. lime treatment, micronisation and ammoniation. Extrusion at 150°C effectively inactivated myrosinase but had relatively little effect on glucosinolate content unless chemicals were added before extrusion; the most effective combination, 5% alkali+1% ferrous sulphate, reduced the total glucosinolate content by 80%. Under the latter conditions very high (>30 μmol g −1 defatted meal) levels of nitriles were produced, leading to the suggestion that nitriles in addition to oxazolidine‐2‐thione and isothiocyanates be used to monitor the effectiveness of processing techniques. None of the extrusion conditions showed any significant effect on reducing sinapine or tannin contents. In view of the chemical data presented, and the probable adverse effects which the processing conditions selected have on the nutritional value of the processed meal it seems unlikely that extrusion will play a significant role in rapeseed detoxification.
Pros and Cons of CAD (2006)

This paper describes the pros and cons of computer-aided design (CAD). CAD packages lack features to easily make the intuitive, complex shapes so pervasive in modern products. It is much easier with CAD to create a part with square features and rectangles and straight lines and round things. Even in a current design project, engineers will sculpt the design in clay, scan it with a digitizer, bring it back into the CAD package, then change it into a solid model and refine that. One of the biggest criticisms of CAD systems is that digital design is slower than sketching and that inhibits the brainstorming process. Today’s systems are not equipped to let engineers play with a design. Engineers start with a basic design and they can change parameters as they draw, but cannot change complete concepts midstream or cut and paste ideas between designs. Most CAD packages include features that track design changes so engineers working collaboratively can see what's been changed, where, when, and why.
The Hypnic Headache Syndrome (1988)

SYNOPSIS Six patients, all but one, men, between the ages of 65 and 77 years, were regularly awakened from sleep at a consistent time of night, sometimes during a dream, by a diffuse headache that persisted for 30 to 60 minutes and was often associated with nausea, without autonomic symptoms. In all cases, headache ceased or was substantially attenuated by a bedtime dose of 300 to 600 mg of lithium. The disorder persisted for one and a half to three years in three of the patients; the others continue to require lithium. It is proposed that this syndrome may be caused by perturbation of a biological clock.
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018)

Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic inflammation, which seems to be a marker of unsuccessful aging. This reshaping of cytokine expression pattern, with a progressive tendency toward a pro-inflammatory phenotype has been called "inflamm-aging." Despite research there is no clear understanding about the causes of "inflamm-aging" that underpin most major age-related diseases, including atherosclerosis, diabetes, Alzheimer's disease, rheumatoid arthritis, cancer, and aging itself. While inflammation is part of the normal repair response for healing, and essential in keeping us safe from bacterial and viral infections and noxious environmental agents, not all inflammation is good. When inflammation becomes prolonged and persists, it can become damaging and destructive. Several common molecular pathways have been identified that are associated with both aging and low-grade inflammation. The agerelated change in redox balance, the increase in age-related senescent cells, the senescence-associated secretory phenotype (SASP) and the decline in effective autophagy that can trigger the inflammasome, suggest that it may be possible to delay age-related diseases and aging itself by suppressing pro-inflammatory molecular mechanisms or improving the timely resolution of inflammation. Conversely there may be learning from molecular or genetic pathways from long-lived cohorts who exemplify good quality aging.
Superpixel lattices (2008)

Unsupervised over-segmentation of an image into superpixels is a common preprocessing step for image parsing algorithms. Ideally, every pixel within each superpixel region will belong to the same real-world object. Existing algorithms generate superpixels that forfeit many useful properties of the regular topology of the original pixels: for example, the nth superpixel has no consistent position or relationship with its neighbors. We propose a novel algorithm that produces superpixels that are forced to conform to a grid (a regular superpixel lattice). Despite this added topological constraint, our algorithm is comparable in terms of speed and accuracy to alternative segmentation approaches. To demonstrate this, we use evaluation metrics based on (i) image reconstruction (ii) comparison to human-segmented images and (iii) stability of segmentation over subsequent frames of video sequences.
X band septum polarizer as feed for parabolic antenna (2010)

Contemporary RHCP and LHCP wave occurs in several applications of microwave communication and measurement system. From this point of view the septum polarizer can be useful. The septum polarizer is a four-port waveguide device. The square waveguide at one end constitutes two ports because it can support two orthogonal modes. A slopping (or stepped) septum divides the square waveguide into two standard rectangular waveguides sharing a common broad-wall. The size of the septum as well as two versions of the waveguides excitation were analyzed and are described in this paper.
New explanation to tableau working method for transportation problems (1998)

Some some properties of transportation problems are introduced. A new proof is given for an important theorem—a set of the column vectors corresponding to a set of variables is linearly independent if and only if it does not contain a closed circuit. According to this theorem and other properties, the relationship between the working method on the tableau and the simplex method is analyzed by the new method. It shows that the working method on the tableau is essentially a special simplex method. Finally, an example is given to illustrate how to solve problems with the transportation tableaus.
A Model for Peaking Units Using the Canadian Electrical Association Data Base (1985)

The Canadian Electrical Association (CEA) is playing a key role in the collection and analysis of outage data for generating equipment in Canada. All Canadian utilities are now collecting data using a single comprehensive reporting procedure. This developnent includes models which provide a useful and accurate representation of the operating history of selected unit types and classes. This paper illustrates the data format for gas turbine or peaking units and illustrates how the CEA data base can be used to generate suitable models for capacity adequacy studies.
Plastified Epoxy Resins Modified by Hydrophilic and Hydrophobic Silica (1998)

Abstract The investigation reports the flow properties of the epoxy resins plasticized with a polyesteric-type plasticizer and modified with hydrophilic or hydrophobic silica. The measurements were carried out by means of a rotary viscometer equipped with a cone-and-plate-type device at shear rates varying between 0.555 and 4860 sec−1, at temperatures ranging from 25°C to 75°C, and at filler contents varying between 0% and 20% w/w, reported for the mixture weight. The Theological parameters evaluated on the flow are the flow index, the consistency index, the yield stress, the limiting high-shear viscosity, and the flow activation energy. The flow data lead to the conclusion that the tested materials exhibit a non-Newtonian rheological behavior of the thixotropic type at low temperatures and of the pseudoplastic type at high temperatures.
Trailer encapsulations (1984)

This RFC discusses the motivation for use of "trailer encapsulations" on local-area networks and describes the implementation of such an encapsulation on various media.
Viscosity of Esters of Saturated Alphatic Acids - Relation to the Synthesis of Fine Lubricating Oils (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTViscosity of Esters of Saturated Alphatic Acids - Relation to the Synthesis of Fine Lubricating OilsAugustus H. Gill and Forest P. DexterCite this: Ind. Eng. Chem. 1934, 26, 8, 881Publication Date (Print):August 1, 1934Publication History Published online1 May 2002Published inissue 1 August 1934https://pubs.acs.org/doi/10.1021/ie50296a018https://doi.org/10.1021/ie50296a018research-articleACS PublicationsRequest reuse permissionsArticle Views400Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Comparison of Genotypes of <i>Escherichia Coli</i> Strains Carrying F18ab and F18ac Fimbriae from Pigs (2009)

Escherichia coli carrying the F18 fimbriae colonize the small intestine of pigs and cause postweaning diarrhea and edema disease. There are 2 closely related antigenic variants of F18, F18ab, and F18ac. While F18ab-positive strains are known to be associated with edema disease, E. coli-carrying F18ac are known to cause diarrhea. One hundred ninety-eight E. coli isolates obtained from cases of diarrhea and edema disease in pigs isolated from feces or intestine were screened for the presence of the fedA gene encoding for F18 fimbriae. To distinguish between F18ab and F18ac, the fedA gene was sequenced in 69 F18-positive isolates/strains. The translated protein sequences of the fedA gene in the 2 variants differ; F18ac protein carries proline at amino acid residue 121, which is substituted or missing in F18ab. The F18ab- and F18ac-positive E. coli strains were compared for the presence of virulence attributes, serotypes of the isolates, and relatedness between the strains. Contrary to earlier reports that E. coli F18ab-positive strains mostly express Shiga toxin and F18ac-positive strains generally express enterotoxins, the current report shows conclusively for the first time that both variant types may carry genes for Shiga toxins and/or enterotoxins. Monoclonal antibodies produced against F18ab or F18ac fimbriae could not distinguish the strains carrying the 2 variants. Therefore, it was concluded that either of the 2 F18 variants, F18ab or F18ac, may be involved in causing postweaning diarrhea or edema disease in pigs.
ChemInform Abstract: SYNTHESIS OF CANNABINOID METHYL ESTERS AND ACIDS (1977)

Abstract Aus dem Olevitolsäureester (I) werden durch Terpenylierung die Al‐Tetrahydro‐ und A′s′‐Tetrahydrocannabinolate (IV) und (VII), das Cannabigerolat (Xa) und sein Isomeres (Xb) sowie das Cannabichromenat (XII) dargestellt.
Performance assessment of XACML authorizations for Supply Chain Traceability Web Services (2012)

Service-Oriented Architecture (SOA) and Web Services (WS) offer advanced flexibility and interoperability capabilities. However they imply significant performance overheads that need to be carefully considered. Supply Chain Management (SCM) and Traceability systems are an interesting domain for the use of WS technologies that are usually deemed to be too complex and unnecessary in practical applications, especially regarding security. This paper presents an externalized security architecture that uses the eXtensible Access Control Markup Language (XACML) authorization standard to enforce visibility restrictions on trace-ability data in a supply chain where multiple companies collaborate; the performance overheads are assessed by comparing `raw' authorization implementations - Access Control Lists, Tokens, and RDF Assertions - with their XACML-equivalents.
Integrated Solid/Nanoporous Copper/Oxide Hybrid Bulk Electrodes for High-performance Lithium-Ion Batteries (2013)

Nanoarchitectured electroactive materials can boost rates of Li insertion/extraction, showing genuine potential to increase power output of Li-ion batteries. However, electrodes assembled with low-dimensional nanostructured transition metal oxides by conventional approach suffer from dramatic reductions in energy capacities owing to sluggish ion and electron transport kinetics. Here we report that flexible bulk electrodes, made of three-dimensional bicontinuous nanoporous Cu/MnO2 hybrid and seamlessly integrated with Cu solid current collector, substantially optimizes Li storage behavior of the constituent MnO2. As a result of the unique integration of solid/nanoporous hybrid architecture that simultaneously enhances the electron transport of MnO2, facilitates fast ion diffusion and accommodates large volume changes on Li insertion/extraction of MnO2, the supported MnO2 exhibits a stable capacity of as high as ~1100 mA h g(-1) for 1000 cycles, and ultrahigh charge/discharge rates. It makes the environmentally friendly and low-cost electrode as a promising anode for high-performance Li-ion battery applications.
실천공학 교육방법론 : 공학교육의 실태와 개선방안에 대한 연구 (2009)

본 논문에서는 지역 산업체를 대상으로 공학교육의 실태를 분석하여 수요지향적 공학교육을 위한 개선방안을 마련하고자 한다. 이를 위하여 공학교육 실무인재양성 교육프로그램인 캡스톤디자인, 현장실습, 주문식 인력양성을 주요 주제로 선정하여 서남권 지역산업체 임직원 대상 산학협동 교육프로그램 운영 실태를 조사하였다. 조사 결과, 서남권 지역산업체 대부분이 산학협동 교육프로그램 운영 경험이 미진하였다. 또한, 현장실습 추진 경험이 있는 산업체에서는 향후 추진계획에 유보적 입장을 보인 반면, 캡스톤디자인 경우 참여의사가 다소 있어 산학협동 교육프로그램별로 실행 모델이 마련되어야 할 것이다. 향후 지역전략 산업 기반 수요지향적 공학교육프로그램 운영을 위한 개선 방안을 마련하고자 한다.
Favipiravir and the Need for Early Ambulatory Treatment of COVID-19 (2020)

The commentary by McCullough emphasizes the urgent need for early ambulatory therapy of coronavirus (CoV) disease 2019 (COVID-19) (1). Unfortunately, no treatment has been proven to prevent disease progression and hospitalization. Although dismissed by McCullough as only a “theoretical” gold standard, randomized controlled trials (RCTs) are absolutely necessary for COVID-19, which in most cases is self-limiting. Despite the challenges of a pandemic, large RCTs, such as RECOVERY (2), have been completed and provided important evidence to guide treatment of COVID-19.
Stability and resource allocation in project planning (2004)

The majority of resource-constrained project scheduling efforts assume perfect information about the scheduling problem to be solved and a static deterministic environment within which the precomputed baseline schedule is executed. In reality, project activities are subject to considerable uncertainty, which generally leads to numerous schedule disruptions. In this paper, we present a resource allocation model that protects a given baseline schedule against activity duration variability. A branch-and-bound algorithm is developed that solves the proposed resource allocation problem. We report on computational results obtained on a set of benchmark problems.