gebhart/patrepeval huggingface dataset:
MAL11 and MAL61 encode the inducible high-affinity maltose transporter of Saccharomyces cerevisiae (1991)

We have investigated the transport of maltose in a genetically defined maltose-fermenting strain of Saccharomyces cerevisiae carrying the MAL1 locus. Two kinetically different systems were identified: a high-affinity transporter with a Km of 4 mM and a low-affinity transporter with a Km of 70 to 80 mM. The high-affinity maltose transporter is maltose inducible and is encoded by the MAL11 (and/or MAL61) gene of the MAL1 (and/or MAL6) locus. The low-affinity maltose transporter is expressed constitutively and is not related to MAL11 and/or MAL61. Both maltose transporters are subject to glucose-induced inactivation.
A low power charge sharing ROM using dummy bit lines (2003)

This paper proposes a shared-capacitor charge-sharing ROM (SCCS-ROM). The SCCS-ROM reduces the swing voltage using the charge-sharing technique of the charge-sharing ROM (CS-ROM). Although the CS-ROM needs three small capacitors per output, the SCCS-ROM shares the capacitors so that it needs only three capacitors. The SCCS-ROM implements the capacitors using dummy bit lines. This not only increases noise immunity but also reduces power. The simulation results, using 0.35 /spl mu/m CMOS technology, show that the SCC-SROM reduces power by 8.4% compared to the CS-ROM.
Characterization of a Multicopper Oxidase Gene from <i>Staphylococcus aureus</i> (2005)

A multicopper oxidase gene from Staphylococcus aureus was cloned and overexpressed. Purified recombinant multicopper oxidase oxidized the substrate 3,3'-dimethoxybenzidine in the presence of copper. Disruption of mco showed copper sensitivity and H(2)O(2) resistance, suggesting roles for mco in copper homeostasis and oxidative stress response. Northern blot analysis showed copper-induced mco transcription.
THE EFFECT OF CODEINE ON INVOLUTIONAL AND SENILE DEPRESSION (1982)

The authors studied the effect of codeine on 12 severely depressed patients who failed to respond to tricyclic antidepressants. They all were in involution. Eight patients received codeine in combination with other tricyclic antidepressants and only one of them showed improvement. Four depressed patients received codeine alone and none of them improved. The patients were kept on codeine up to three weeks. The dose was gradually increased from 90 mg/day to 180 mg/day. All patients suffered from severe constipation--more than what they had on tricyclic antidepressant medication. All of the patients experienced a sedative effect. None of them had euphoria and none of them developed dependence. After the failure of codeine, the patients finally accepted electroconvulsive therapy or monoamine oxidase inhibitors, and with one exception, all improved.
Olefin metathesis in non-degassed solvent using a recyclable, polymer supported alkylideneruthenium (2001)

Polystyrene-supported ruthenium complex 8 is a robust pro-catalyst for olefin metathesis that can be used in non-degassed solvents and recycled without added stabilisers.
The Conditions Associated with Peripheral Employment in Australia (1994)

Aims to subject to empirical scrutiny the claim that peripheral work is characterized by a range of undesirable characteristics. The analysis of data from the Australian Workplace Industrial Relations Survey (AWIRS) clearly shows that there is a link between peripheral forms of employment and undesirable working conditions in Australian workplaces. Further, the negative features of peripheral employment apply regardless of workplace size, sector or industry. In conjunction with the evidence of the growth of a peripheral workforce and the marked over‐representation of women in such jobs, supports the argument that peripheral work contributes to inequality in Australian workplaces.
The Present Knowledge of the Inflammatory Process and the Inflammatory Mediators (1994)

Endothelial damage, synovial oedema, fibrin deposition, polymorphonuclear cell (PMN) invasion, and mild lining cell hyperplasia characterize acute inflammatory arthritis. Later on, perivascular tissue is infiltrated by mononuclear cells. The early events are mediated by interactions between PMNs and endothelial cells. Both parts in the adhesion event are activated with multiple stimuli resulting in complex interactions of varying intensity and duration. Adhesion molecules present on the surface of PMNs (L-selectin) or induced by inflammatory stimuli (beta 2-integrins) mediate PMN adhesion to activated endothelium, which has counter receptors (E-selectin for L-selectin and ICAM-1 and ICAM-2 for beta 2-integrins). At the initial phase L-selectin initiates the rolling of PMNs on endothelial cells. Further stimuli result in a more prolonged adhesion between PMNs and endothelium. At the side of endothelium, induction of P-selectin and PAF by histamine, thrombin and LTC4 contribute to the acute rolling of PMNs on endothelial surface. Tumor necrosis factor (TNF), interleukin-1 (IL-1) and lipopolysaccharide activate endothelial cells to synthesize interleukin-8 (IL-8), a potent chemotactic and proadhesive mediator for PMNs, and further adhesion molecule (E-selectin), a mediator of long-term adhesion between PMN and endothelium. After adhesion and migration to the focus of inflammation, PMNs induce inflammation by aggregating, releasing hydrolyzing enzymes, generating lipid peroxidation products such as prostaglandins and LTB4, and oxygen derived free radicals. In studies on the pathogenesis of seronegative spondyloarthropathies, we have shown persistently aberrant PMN function evidenced by enhanced chemotaxis and high production of toxic oxygen derived free radicals by PMN.(ABSTRACT TRUNCATED AT 250 WORDS)
Expression and significance of myeloid differentiation factor 88 in non-small cell lung carcinoma and normal paracancerous tissues (2015)

We studied the expression level of myeloid differentiation factor 88 (MyD88) in non-small cell lung carcinoma (NSCLC) and normal paracancerous tissues, to determine its relationship with clinical pathological characteristics and prognosis. In total, 82 NSCLC patients who had received surgical treatment in our hospital between September 2008 and December 2013 were selected for this study. Another 82 normal paracancerous lung tissue samples were used as controls. All patients had complete clinical records, and they were followed-up for 5 years. The expression level of MyD88 protein was detected by immunohistochemical assay. The positive expression rate of MyD88 in NSCLC tissues (62.2%) was markedly higher than that in normal tissues (10.9%), and was independent of patient characteristics such as age, gender, pathological pattern, history of smoking, and tumor size (P > 0.05). However, MyD88 expression was significantly correlated with degree of differentiation, clinical staging, and lymphatic metastasis (P < 0.05), and was negatively correlated with prognosis. The 5-year survival rate of patients with positive MyD88 expression was significantly lower than that of patients without positive expression (P < 0.05). MyD88 was expressed at a higher level in NSCLC tissues and was closely associated with poor prognosis. MyD88 may be a novel eligible target for treating NSCLC.
Water and Energy-Metabolism and Estimated Food-Consumption Rates of Free-Living Wambengers, Phascogale-Calura (Marsupialia, Dasyuridae) (1989)

The metabolic rates and water fluxes of free-living Phascogale calura were determined with doubly labelled water. The highest rates of water influx occurred in October, when the adult population consisted of lactating females only. The highest metabolic rates occurred in June, and the lowest rates of both water influx and metabolism occurred in March. The value of the data in designing toxic baits for the control of foxes or other exotic pests, while minimising the hazard to phascogales of accidental poisoning, is discussed.
A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry (2001)

The mono-(dimethylaminoethyl) succinyl (MDMAES) ester is a new derivative for rapid, mild, and sensitive electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of cholesterol and dehydrocholesterol. It is an order of magnitude more sensitive than the previous most practical alternative, the N-methylpyridyl ether derivative. The MDMAES derivative was used to develop a rapid screening procedure for the biochemical diagnosis of Smith-Lemli-Opitz syndrome (SLOS) by measuring the dehydrocholesterol/cholesterol ratio in plasma (5 microl) and plasma spotted onto filter paper. Details of the synthesis of [25,26,26,26,27,27,27-(2)H7]-7-dehydrocholesterol, used as a standard for quantitation, are included. The measurement of total sterols as MDMAES esters, after base hydrolysis of plasma, afforded a dehydrocholesterol/cholesterol ratio of 0.05-2.95 for SLOS patient samples (n = 5) compared with 0.001-0.003 for normal adult controls (n = 20). Direct hexane extraction of plasma without base hydrolysis enabled the measurement of free sterols with a total sample analysis time of <1 h. The free dehydrocholesterol/cholesterol ratio was 0.10-4.47 for SLOS patient samples (n = 5) and 0.003-0.011 for normal adult controls (n = 20).
Scanning electrochemical mass sensitivity mapping of the quartz crystal microbalance in liquid media (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTScanning electrochemical mass sensitivity mapping of the quartz crystal microbalance in liquid mediaA. C. Hillier and M. D. WardCite this: Anal. Chem. 1992, 64, 21, 2539–2554Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://doi.org/10.1021/ac00045a014RIGHTS & PERMISSIONSArticle Views651Altmetric-Citations151LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Altered Sleep Mechanisms following Traumatic Brain Injury and Relation to Waking Function (2015)

Sleep difficulties are commonly reported following traumatic brain injury (TBI), but few studies have systematically examined the neurophysiological characteristics of sleep. Sleep EEG was quantified over multiple nights to examine mechanisms underlying sleep disruption in individuals who had sustained a TBI and to explore the relationship between sleep disruption and waking function. Sleep was recorded from 20 individuals with a TBI (18-64 years) and 20 age-matched controls over two uninterrupted nights, as well as during a night where auditory stimuli were delivered. All participants underwent neuropsychological testing and waking performance assessment. Compared to controls, the TBI group had subjective complaints of falling asleep, delayed sleep onset on polysomnography (PSG), less Slow Wave (< 1 Hz) and delta (1-4 Hz) EEG power in non-REM sleep, fewer spontaneous and evoked k-complexes, reduced periodicity of spontaneous k-complexes, and lower amplitude of evoked k-complexes. While for controls, the density, duration and periodicity of sleep spindles diminished with deepening of non-REM as typically observed, this pattern was disrupted in the TBI group with peak spindle presentation occurring in Stage 3 sleep. Night-to-night-stability of Stage 2 spindles was high for controls but absent for the TBI group. Greater injury severity was related to fewer evoked k-complexes and lower spindle density. Greater spindle production predicted better waking function in the TBI group. Taken together, these data demonstrate impairment in sleep regulatory and inhibitory mechanisms as factors underlying sleep complaints following a TBI. Spindle generation may be adaptive or a marker of resiliency following TBI.
인질과 스톡홀름 신드롬 (2005)

스톡홀름 신드롬이란 인질로 잡힌 사람들이 범인들과 일체화되어 오히려 사신 들을 볼모로 잡은 법인들에게 긍정적인 반응을 보이는 심리적 현상을 말한다. 갇힌 상태에서 처음에 인질들은 범인들을 두려워하지만, 시간이 흐르면서 자신들을 구출하려는 경 찰에게 불만을 가지면서, 사건이 끝난 뒤에도 계속해서 범인들에게 호의적인 감정을 가지고 그들에게 불리한 증언을 거부하는 경우도 있었다. 나아 가서 인질들은 범인들이 자신을 해치지 않는 것을 감사하게 생각하면서 그들에게 온정을 느끼는 현상이 발견되 었다. 본 연구가 논의한 바와 같이, 감금상태에서 증후군에 젖은 인질들은 여러 가지 역설적 징후들을 보인다. 많은 연구들을 스톡홀름신드롬의 발생의 촉진상황으로 네 가지를 언급하며, 동시에 저해상황들도 분석하고 있다. 특히 신드롬의 구성요소로서 경 찰에 대한 불신과 반감은 자세한 검토를 필요로 한다. 그리고 인질상황에서 감정전이는 인질→범인 스톡홀름 신드롬만 아니라 인질←범인 리마 신드롬도 발견되었다. 절망적으로 갇힌 상태에서 하나의 살아남기 위한 장치의 작동으로 이해되어야 한다. 따라서 법집행기구들은 신드롬의 발생이 인질들이 살아남을 수 있는 가능성올 높인다고 믿어서 스톡홀름 신드롬에 주목하고 있는 것이다.
CHINESE MEDICINE (CM) matters (2008)

we launched Chinese Medicine (CM), a peer-reviewed, open access, international, interdisciplinary and scholarly journal in Chinese medicine Two years on, with the best efforts and sometimes personal sacrifices made by the authors, editorial and advisory board members, reviewers, and the editorial teams in Macao and at BioMed Central in London, we have published a total of thirty-two high quality research and review articles. In addition, four print issues have also been distributed to many individuals and institutions worldwide.
Effects of 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide on nitric oxide production in cultured human endothelial cells (1999)

14-deoxyandrographolide (DA) and 14-deoxy-11,12-didehydroandrographolide (DDA) are two diterpenoids isolated from A. paniculata, a popular folk medicine used as an antihypertensive drug in Malaysia. We have previously reported that DDA exhibited a greater hypotensive effect in anaesthetized rats and a vasorelaxant activity in isolated rat aorta, compared with DA. Their vasorelaxant activities were mediated through the activation of the enzymes, nitric oxide synthase (NOS) and guanylyl cyclase. The present study demonstrated that both DA and DDA stimulated nitric oxide (NO) release from human endothelial cells. DDA compared with DA caused a greater production of NO; this is in line with the finding of the earlier study that the vasorelaxant effect of DDA was more dependent on endothelium than DA.
Understanding of Impact and Propagation of Risk based on Social Network Analysis (2018)

The inherent risks within urban infrastructure system exert significant consequences on the dependent community. As the risk is a product of a complex set of network processes. the complexity is better assessed by understanding the risk nature, interrelationship dynamic and impact propagation pattern. Experts and professionals often use various assessment models and tools to help understand risk nature. Nonetheless, such models are not designed to capture the interconnections that shape risks based on community participation. This study proposes a novel model to capture, draw and simulate the risk impact propagation pattern and interrelationships based on a single mode network analysis. Following the concept of social risk amplification, a process of developing risk network map based on community perspective is presented. The proposed model is applied on a water supply infrastructure system. A total of 30 risk events were used for collection of data from 126 individuals across eight different stakeholder categories. This study reveals that participatory networked approaches to risk interrelationship analysis are better suited to capturing the intricate processed that shape infrastructure risk. This approach could potentially provide a way forward for developing mitigation strategy, intervention and policy that seek to address risk complex phenomena and thus enhancing both infrastructure and community resilience.
Porphyrins in polymeric matrices, micelles, and vesicles, VII. Hexadecahydro‐29<i>H</i>,31<i>H</i>‐tetrabenzo[<i>b,g,l,q</i>]porphin and ‐octayl octaacetate (1985)

Abstract The title compounds 5 and 10a were synthesized. The octaacetate 10a was hydrolyzed to give a water‐soluble porphyrin. Its interactions with vesicle membranes were characterized.
A prediction-based neural network scheme for lossless data compression (2002)

This paper proposes a modified block-adaptive prediction-based neural network scheme for lossless data compression. A variety of neural network models from a selection of different network types, including feedforward, recurrent, and radial basis configurations are implemented with the scheme. The scheme is further expanded with combinations of popular lossless encoding algorithms. Simulation results are presented, taking characteristic features of the models, transmission issues, and practical considerations into account to determine optimized configuration, suitable training strategies, and implementation schemes. Estimations are used for comparisons of these characteristics with the existing schemes. It is also shown that the adaptations of the improvised scheme increases performance of even the classical predictors evaluated. In addition, the results obtained support that the total processing time of the two-stage scheme can, in certain cases, be faster than just using lossless encoders. Findings of the paper may be beneficial for future work, such as, in the hardware implementations of dedicated neural chips for lossless compression.
The Stability of Aqueous Chloramine Solutions (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Stability of Aqueous Chloramine SolutionsL. F. Audrieth and R. A. RoweCite this: J. Am. Chem. Soc. 1955, 77, 18, 4726–4728Publication Date (Print):September 1, 1955Publication History Published online1 May 2002Published inissue 1 September 1955https://pubs.acs.org/doi/10.1021/ja01623a010https://doi.org/10.1021/ja01623a010research-articleACS PublicationsRequest reuse permissionsArticle Views374Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Investigation of Flow in an Axially Symmetrical Heated Jet of Air (1943)

The work done under this contract falls essentially into two parts: the first part was the design and construction of the equipment and the running of preliminary tests on the 3-inch jet, carried out by Mr. Carl Thiele in 1940; the second part consisting in the measurement in the 1-inch jet flow in an axially symmetrical heated jet of air. (author)
Deep-Learning for Occupancy Detection Using Doppler Radar and Infrared Thermal Array Sensors (2019)

Deep-Learning for Occupancy Detection Using Doppler Radar and Infrared Thermal Array Sensors Milad Abedi and Farrokh Jazizadeh Pages 1098-1105 (2019 Proceedings of the 36th ISARC, Banff, Canada, ISBN 978-952-69524-0-6, ISSN 2413-5844) Abstract: An accurate, real-time monitoring of the occupancy state of each space is a necessity for applications such as energy-aware smart buildings. In this paper, we have studied the feasibility of using Doppler Radar Sensors (DRS) and Infrared Thermal Array Sensors (ITA) to build an effective occupancy detection framework. The proposed sensor types are cost-effective and protect the privacy of the occupants. We have utilized Deep Neural Networks (DNN) to analyze the sensor data without any need for specialized feature extraction that is necessary for classical machine learning approaches. The results are indicative of the feasibility and the reliability of using both sensor types for detection of the occupancy state. While a threshold-based approach reached an average accuracy of 84.3% and 86% for the DRS and ITA sensors respectively, DNN models were able to achieve average accuracies of 98.9% and 99.96% for the DRS and ITA sensors respectively, thereby demonstrating the feasibility and success of the proposed framework. Keywords: Doppler Radar Sensor; Infrared Thermal Array Sensor; Deep Learning; Deep Neural Network DOI: https://doi.org/10.22260/ISARC2019/0146 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
Importância da Biologia Molecular na Ciência Forense (2013)

O presente trabalho visa o estudo da importância da Biologia Molecular na Ciencia Forense, bem como caracterizar seus usos e aplicacoes. A Analise Forense por DNA e uma area cientifica em que a partir de conhecimentos e tecnicas sobre genetica, auxilia a justica e se desvendam crimes.  Essa area nos proporciona diversas facilidades, sendo que as tecnicas podem ser realizadas a partir de qualquer fonte de material biologico. Os avancos nas tecnologias de DNA surtiram um enorme impacto no campo da ciencia forense. Com uma incrivel sensibilidade e um alto poder de discriminacao, a analise de DNA tem sido uma poderosa ferramenta para a identificacao humana e investigacoes criminais. O presente estudo fara uma revisao sobre as tecnicas de Biologia Molecular, que foram desenvolvidas nas ultimas decadas, tendo como principio o estudo de diferentes polimorfismos de DNA para a identificacao precisa de individuos. Outra tecnica que tambem sera exposta, PCR (cadeira de polimerase), e um metodo laboratorial capaz de copiar milhoes de vezes um segmento do DNA, que se destaca perante outras tecnicas por ser um procedimento relativamente simples e facil de realizar em laboratorio, gerando resultados precisos e satisfatorios, em um curto espaco de tempo.
Space-time turbo equalization and symbol detection in frequency selective MIMO channels (2002)

A computationally efficient space-time turbo equalization algorithm is derived for frequency selective multiple-input multiple-output (MIMO) channels. The algorithm is an extension of the iterative equalization algorithm by Reynolds and Wang (2001) for frequency selective fading channels. This paper's proposed equalizer performs MIMO channel estimation, multiple user signal detection, and decoding, jointly all in an iterative manner. The iterative channel estimator achieves high accuracy in estimating channel parameters even if only a relatively small number of unique word symbols are available. The multiple user signal detector (MUSD) consists of soft interference cancellers for the multiple users, each followed by a minimum mean square error (MMSE) filter. With this simple structure, the proposed detector achieves a drastic reduction in computational complexity compared with conventional trellis-based turbo equalizers. Simulation results show the proposed equalizer can properly separate multiple user signals in frequency selective MIMO channels.