gebhart/patrepeval huggingface dataset:
Basal cell carcinoma: cell of origin, cancer stem cell hypothesis and stem cell markers (2010)

Cancer stem cells have recently been described in several high-grade neoplasms. It is still unclear if they also occur in cutaneous malignancies. Cancer stem cells are not identical with somatic stem cells. The presence of tumour stem cells in a neoplasm does not in itself equal that the tumour derives from a somatic stem cell. A cell originally lacking stem cell characteristics could also acquire those features during the course of carcinogenesis and then becomes the clonal founder cell of a tumour. Basal cell carcinoma (BCC) is the most common cutaneous malignancy. A plethora of various stem cell markers has been applied to study its cellular origin. Intriguingly, the anatomical origin of BCC is still uncertain. This review will discuss the various stem cell markers used in BCC and the cellular origin of this tumour, and touches briefly on the possibility of cancer stem cells in BCC. If BCC or other skin cancers harbour tumour stem cells, these cells could be specifically targeted, making use of specific cell surface molecules such as receptor proteins. Novel drugs directed against those receptor proteins could replace currently available shotgun approaches including imiquimod.
PHYSIOLOGY OF CA TREATED PRODUCE (2003)

Storage of fresh horticultural perishables within the optimum range of low oxygen and/or elevated carbon dioxide atmospheres for each commodity reduces their respiration and ethylene production rates. However, outside this range respiration and ethylene production rates can be stimulated indicating a stress response, which can contribute to incidence of physiological disorders and increased susceptibility to decay. Exposure to 30-80 kPa oxygen atmospheres stimulates respiration and ethylene production and action in some commodities. Carbon dioxide-enriched atmospheres inhibit activity of ACC synthase, while ACC oxidase activity is stimulated by low carbon dioxide and inhibited at high carbon dioxide and/or low oxygen concentrations. Ethylene action is inhibited by elevated carbon dioxide atmospheres. Optimum CA retard loss of chlorophyll, biosynthesis of carotenoids and anthocyanins, and biosynthesis and oxidation of phenolic compounds. CA reduce the activity of cell wall degrading enzymes that cause fruit softening and enzymes involved in lignification leading to toughening of vegetables. CA influence flavor quality by reducing loss of acidity, starch to sugar conversion, and biosynthesis of aroma volatiles, especially esters. Retention of ascorbic acid and other vitamins results in better nutritional quality, including antioxidant activity, of fruits and vegetables when kept in their optimum CA.
EFFECT OF COMPOUND DANSHEN INJECTION ON EXPRESSION OF IL- 1β mRNA BY SYNOVIOCYTES IN CIA RATS (2002)

Objective:To study the effect of compound Danshen injection (CDI) on the expression of IL - 1β mRNA by synoviocytes in collagen Ⅱ induced arthritis (CIA) rats.Method:The expression of IL -1β mRNA by synoviocytes in CIA rats was tested by RT PCR technique. Result:High dosage of CDI could down regulate the expression of IL - 1β mRNA by synoviocytes in CIA rats.Conclusion: The curative effect of CDI on rheumatoid arthritis is concerned with down regulated expression of IL - 1β mRNA of synoviocytes.
Gangliosides in Isolated Neurons and Glial Cells (1967)

Gangliosides occur in much greater amounts in clean isolated neurons and in the neuropil teased from immediately around the neuron cell body and dendrites than in isolated clumps of glial cells. Since the zone of neuropil adjacent to neurons is richest in terminal axons and synaptic endings, these findings indicate a specific concentration of these sialoglycolipids in synaptic membranes.
Breakdown of N-terminally modified peptides and an isopeptide by rumen microorganisms (1993)

Treatment of Trypticase peptides with acetic anhydride, succinic anhydride, or maleic anhydride inhibited their breakdown to ammonia by rumen microorganisms by an average of 89% after 12 h of incubation in vitro. All three treatments gave similar protection. Acetylation also protected dipeptides containing lysine and methionine from degradation. However, more effective protection was obtained by linking lysine and methionine as N-epsilon-methionyl lysine.
Isotone functions on partially ordered linear algebras with a multiplicative diagonal map (1977)

The diagonal of the product of two triangular matrices is the product of the diagonals of each matrix. This idea is used to characterize Dedekind <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="sigma"> <mml:semantics> <mml:mi>σ</mml:mi> <mml:annotation encoding="application/x-tex">\sigma</mml:annotation> </mml:semantics> </mml:math> </inline-formula>-complete lattice ordered linear algebras which admit isotone functions with familiar functional and order properties as possessed by the real-valued logarithm or root function.
An efficient residue-to-decimal converter (1981)

One of the fundamental problems with residue arithmetic is the difficulty associated with residue-to-decimal conversion. In this paper, several new efficient conversion algorithms are presented. They span a practical fixed-point dynamic range.running from 12 to 36 bits with execution speed measured in nanoseconds. The mathematical foundations of the developed methods are discussed in detail and realizable architectures presented.
A Remote Surveillance Model for Appliance Control (2010)

Remote appliance control is an important vision for the smart home. Even in the next few decades, it is inevitable that conversional appliances and smart appliance will coexist together to help people live better. For this reason, this research proposed a remote control model for the conversional appliances to integrate with smart home environment. In this model, a smart home portal combined with video surveillance system was used to realize the appliance control. Total control cycle is base on what you see is what you have done. The main benefits of this model come from the mature technology, simple design, light-weight architecture, and practicable for implementation.
Inhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis (2009)

Depending on the strength of ErbB2 signaling there is a differential regulation of CHOP and eIF2alpha phosphorylation. ErbB2 uncouples in basal conditions eIF2alpha phosphorylation from CHOP induction. However, this signal was restored by salubrinal treatment in Wt-ErbB2 expressing MCF10A cells as these DCIS-like structures underwent luminal clearing. In CA-ErbB2 structures apoptosis is not induced by salubrinal and instead a state of quiescence with reduced proliferation was achieved. Treatments that stabilize P-eIF2alpha levels may be effective in treating ErbB2 positive cancers without severely disrupting normal tissue function and structure.
Building and Evaluating the Campus Online File Sharing Tool: UNC Dropbox System (2019)

In this project, a web-based online file sharing system called UNC Dropbox System was designed and implemented to provide UNC-CH affiliated personnel a free and secure file sharing platform. The system adopted the UNC Single Sign-on Service for authentication, which not only ensured the system security but also seamlessly integrated the system to the existing UNC web services. A small group user testing with 12 participants from three UNC departments was conducted after system implementation. Participants were asked to test the system and submit a survey to evaluate the system from five aspects (content, accuracy, format, ease of use and timeliness). Survey answers were quantified to calculate user satisfaction scores on the performance of the system. The final results indicated that testing participants were generally satisfied with their experience with the system. User suggestions have also been collected during the system testing as important guidance for the future system improvements.
Pyrolysis of Lactic Acid Derivatives. Production of Phenyl and o-Tolyl Acrylate<sup>*</sup> (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrolysis of Lactic Acid Derivatives. Production of Phenyl and o-Tolyl Acrylate*E. M. Filachione, J. H. Lengel, and C. H. FisherCite this: J. Am. Chem. Soc. 1944, 66, 3, 494–496Publication Date (Print):March 10, 1944Publication History Published online1 May 2002Published inissue 10 March 1944https://pubs.acs.org/doi/10.1021/ja01231a060https://doi.org/10.1021/ja01231a060research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Targeted Genome Editing Tools for Disease Modeling and Gene Therapy (2014)

The development of custom-designed nucleases (CDNs), including zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), has made it possible to perform precise genetic engineering in many cell types and species. More recently, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system has been successfully employed for genome editing. These RNA-guided DNA endonucleases are shown to be more efficient and flexible than CDNs and hold great potential for applications in both biological studies and medicine. Here, we review the progress that has been made for all three genome editing technologies in modifying both cells and model organisms, compare important aspects of each approach, and summarize the applications of these tools in disease modeling and gene therapy. In the end, we discuss future prospects of the field.
Les examens préventifs (1949)

info:eu-repo/semantics/published
Hardware and software architecture of intelligent vehicles and road verification in typical traffic scenarios (2018)

Intellectualisation is one of the three reforming technologies in automotive industry, which is now changing the mobility mode and human society. High safety and intelligence are the pre‐requisites for putting self‐driving vehicles into markets. This study presents the hardware and software architecture for intelligent vehicles, as well as their road verification in typical traffic scenarios. The hardware system includes environmental sensors, computing platforms, vehicle actuators, and vehicle platforms, which is able to provide redundant protection against the main controller failure. The software system includes environmental perception module, scene cognition module, decision and control module, human–computer interaction module and public service support module. To evaluate the performance of the developed architecture, the road tests of automated driving system were carried out in two typical traffic scenarios, including: (i) closed road test in Yuanboyuan region; (ii) open road test on Beijing‐Tianjin highway. The real road test shows that the designed hardware and software systems for intelligent vehicles have desirable robustness, which can realise accurate and reliable environment perception, decision‐making and motion control.
Transient miliaria profunda and heat incapacitation (1955)

Transient miliaria profunda and heat incapacitation Get access F.P. Ellis, F.P. Ellis Medical Research Council's Royal Naval Tropical Research Unit, Singapore and University College Hospital, Singapore Search for other works by this author on: Oxford Academic PubMed Google Scholar P.J. Hare, P.J. Hare Medical Research Council's Royal Naval Tropical Research Unit, Singapore and University College Hospital, Singapore Search for other works by this author on: Oxford Academic PubMed Google Scholar A.R. Lind A.R. Lind Medical Research Council's Royal Naval Tropical Research Unit, Singapore and University College Hospital, Singapore Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 49, Issue 5, September 1955, Pages 437–443, https://doi.org/10.1016/0035-9203(55)90008-0 Published: 01 September 1955
Pretesting Questionnaires: Content Analyses of Respondents' Concurrent Verbal Protocols (1993)

Conventional questionnaire pretesting methods focus on directly identifying question defects, such as an ambiguous question. This paper proposes a new method that identities respondents' cognitive difficulties as they form answers to survey questions. It entails a content analysts of concurrent verbal protocols elicited during pretest interviews. The effectiveness of the methodology is illustrated with pretests of multiple versions of the same survey. The results are used to illustrate how this method yields diagnostic information about questionnaire problems and improvements. Then, the results are compared with the results of observational monitoring by managers. The findings indicate that a questionnaire pretesting methodology that quantifies respondents' cognitive difficulties is a useful enhancement for identifying and “improving” defective questions.
Interface Instrumentation between Computer and Spectrophotometer for Reaction Rate Measurements (1970)

Abstract An instrument interface which generates an output voltage level proportional to rate of change of an input voltage is described. The interface permits direct connection of routine spectrophotometric rate measurements to a real-time laboratory computer system. The form of the voltage level output enables the computer to read rates in the same manner as peaks are read for AutoAnalyzers, permitting the clinical laboratory LABCOM system to compute and report results for rate methods with no software changes. Spectrophotometric rates from about 10 to 0.025 absorbance units per min can be measured with an accuracy and precision of less than 1% relative in measurement times of about 10 to 30 s, respectively. The interface is readily constructed from commercially available components. Test results are presented for simulated rates, lactic dehydrogenase, and alkaline phosphatase.
Comparison of bleeding tendency, factor XI coagulant activity, and factor XI antigen in 25 factor XI-deficient kindreds (1985)

The relationship of clinical bleeding tendency and factor XI antigen (XI:Ag) in factor XI deficiency was studied in 78 members of 25 factor XI-deficient kindreds. Factor XI:Ag was measured in a competitive radioimmunoassay, using monospecific, heterologous anti-factor XI antibody. 125I-labeled factor XI, and staphylococcal protein A as the precipitating agent. Deficiency of factor XI clotting activity (XI:C), less than 0.62 U/mL, occurred in 48 individuals, 22 of whom experienced postoperative or posttraumatic bleeding: Their mean factor XI:C was 0.21 +/- 0.04 U/mL (SEM), and factor XI:Ag was 0.23 +/- 0.04 U/mL. The remaining 26 had no clinical bleeding, many despite surgical challenge: Their mean factor XI:C was 0.30 +/- 0.04 U/mL, and factor XI:Ag was 0.34 +/- 0.05 U/mL. In all, 13 kindreds had between 1 and 11 members with bleeding; the other 12 had none with deficient hemostasis. Two heterozygous factor XI-deficient individuals appeared to be positive for cross-reacting material (CRM+). The slope of the regression line for factor XI:C and factor XI:Ag data points in the 78 individuals tested did not differ from control, and all points fell within 95% confidence limits derived from control. In conclusion, bleeding tendency appears to be consistent within a given kindred and is not determined exclusively by factor XI:C or factor XI:Ag levels.
Electric current sensors employing spun highly birefringent optical fibers (1989)

The theory of highly elliptically birefringent fibers fabricated by spinning a linearly birefringent fiber during the draw is described. These fibers are particularly interesting for application as Faraday-effect fiber current monitors, since, in contrast to conventional fibers, they can be wound in small multiturn coils while retaining their sensitivity. The fiber and its application in three optical schemes are modeled using Jone calculus and are also experimentally investigated. A simple optical configuration is proposed, combining the elliptically birefringent fiber and a broad-spectrum light source. An accurate, compact, and robust current monitor is obtained. The sensor is characterized by a measurement repeatability of +or-0.5%, a temperature drift of 0.05%/ degrees C and a sensitivity of 1 mA RMS/Hz/sup 1/2/. Further, the performance of this sensor with optimized fiber length for a given measurement bandwidth is predicted.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Convention on International Trade in Endangered Species: Fifteen Years Later (1990)

one nations initially signed the treaty; however, participation has expanded at such a remarkable rate that by 1988 the treaty had ninetyeight signatories. 15 CITES attempts to control wildlife trade by requiring special export and import permits for international commerce in endangered species. A. OverviewThe convention focuses exclusively on the regulation of international trade. 16 It contains no restrictions on domestic trade or requirements for habitat protection that could be construed as infringements on sovereignty.Although the treaty establishes a permanent Secretariat for administrative purposes, 17 it creates no supranational enforcement structure.Nevertheless, it does require parties to designate one "Management Authority" to grant import and export permits and at least one "Scientific Authority" to determine whether trade in a particular species is detrimental to its survival.' 8 United States' Adoption of CITESThe United States Congress ratified and implemented CITES as one part of the Endangered Species Act ("ESA"). 19 The United States Supreme Court has characterized the ESA as "the most comprehensive legislation for the preservation of endangered species ever
Loss of Aerial Mycelium and other Changes in Streptomycete Development due to Physical Variations of Cultural Conditions (1955)

Summary: Several isolates of monosporous lines of Streptomyces coelicolor, both normally pigmented and colourless variants, were obtained by microdissection of young vegetative mycelia. In each case their properties largely resembled those of the parents. This material was studied together with three strains of Streptomyces scabies of varying degrees of virulence, which had been isolated from potato scab lesions. Modifications of growth were noted with respect to gross colonial morphology on agars containing detergents, structure of aerial mycelium arising from various types of surfaces, and development of germinating spores in liquids and in contact with non-nutritive plane surfaces. In both species-groups those organisms which produced least aerial mycelium on stock nutrient agar were most susceptible to the inhibitory influence of 0·1% Gemex 29 on the development of aerial mycelium in simpler media. Distorted aerial growths on detergent agar resembled irregular swollen sporogenous filaments produced in pectin + ammonium salt liquid media. These were also reminiscent of cases of sporogenesis in submerged cultures described by other workers. Apart from surface tensions operating at the air/medium interface, the relative degree of humidity in the culture vessel was found to have some effect upon variation of spore size. Germinating spores and young filaments growing in contact with plane surfaces were more prone to elongation than those growing in liquids. Branching was also influenced to a considerable extent by the nature of the physical environment.
Analysis on the influence of measurement error on state of charge estimation of LiFePO4 power Battery (2011)

The error sources of state of charge(SOC) estimation of li-ion battery based on Kalman filter is analyzed in this paper. To LiFePO4 power battery, the extremely flat part during the normal SOC range of SOC-OCV curve will require strong restriction to the voltage detection especially. This paper aims at the influence of the measuring precision of the voltage and current signal of battery management system (BMS) to SOC estimation of the li-ion battery including LiFePO4 battery. A simulation analysis is performed independently in Simulink on the assumption that other factors are under ideal conditions, in which the effects of Gaussian white noise and offset error of measurement of BMS are discussed respectively to simulate the actual vehicle condition. The principle to the precision index design of BMS is proposed according to the analysis result, in addition, a high-precision data acquisition system is developed as a precise calibration benchmark device for BMS.
Preparation, Characterization and Properties of Paper Sheets Made from Chemically Modified Wood Pulp Treated with Metal Salts (1998)

Abstract Three chemically modified wood pulps (CEWP, AOWP and CmEWP) were prepared and used as a substrates for paper sheets. The effect of treating the chemically modified wood pulps with CuCl2 and FeCl3 salts on the mechanical and thermal properties of the formed paper sheets, in addition to their antimicrobial action on some microorganism were studied. The prepared sheets were characterised by IR-spectra, micro-analyses and magnetic succeptibility measurements. The thermal degradation of the prepared sheets has been investigated by means of non-isothermal TG measurements using Coats and Redfern model. The method of least squares was applied to estimate the appropriate order of degradation reaction (n), and consequently the activation parameters. The results obtained reveal that, paper sheets containing Cu(II) ions have a higher strength properties, thermal stabilities, antimicrobial action and magnetic property than paper sheets prepared from untreated and FeCl3-treated modified pulps. Paper sheets prepared from treating the derivatives of partially cyanoethylated wood pulp (AOWP and CmEWP) have high magnetic succeptibility value compared with paper formed from adding Fe2O3, as conventional filler for magnetic paper manufacture. The regression equation which represents the relation between mechanical properties (Q z), crystallinity index and activation energy was also proposed. Key Words: Paperwood pulpmetal saltsproperties
Nanometer sidewall lithography by resist silylation (1989)

A new and simple approach of nanometer-scale sidewall formation has been explored and developed for dry-etching-based pattern transfer techniques. The sidewalls are formed by applying a solvent-based silylation process to the optically exposed and developed resist pattern, followed by an anisotropic oxygen reactive ion etching (RIE) step. The new technique is capable of forming sidewall masks with dimensions ranging from 50 to 500 nm, depending on the silylation conditions. The sidewall masks have been used for successful pattern transfer into SiO2 and Si3N4 by CF4–RIE. This new and simple nanometer sidewall formation technique is easily reproducible and very uniform and, in certain application areas, might be an alternative to more complex and expensive lithography techniques.