gebhart/patrepeval huggingface dataset:
Complete remission in pure red cell aplasia after plasmapheresis (1985)

A 17-year-old girl with a severe pure red cell aplasia (PRCA) and an appropriate elevation of erythropoietin titres was treated successfully with plasmapheresis, during which plasma was exchanged with human albumin and Ringer lactate. Before this treatment, therapeutic attempts with prednisolone, oxymetholone and infusions with fresh frozen plasma had all been without effect. Bone marrow culture studies revealed an inhibitory activity against BFU-E in the plasma, an activity which could not be demonstrated after the plasmapheresis. 22 months after the plasmapheresis the patient is still healthy without any medication. This case adds additional evidence for the presence of a pathogenetic erythroid inhibitory factor in the plasma of some patients with PRCA.
The <i>Wt1</i><sup>+/R394W</sup> Mouse Displays Glomerulosclerosis and Early-Onset Renal Failure Characteristic of Human Denys-Drash Syndrome (2004)

Renal failure is a frequent and costly complication of many chronic diseases, including diabetes and hypertension. One common feature of renal failure is glomerulosclerosis, the pathobiology of which is unclear. To help elucidate this, we generated a mouse strain carrying the missense mutation Wt1 R394W, which predisposes humans to glomerulosclerosis and early-onset renal failure (Denys-Drash syndrome [DDS]). Kidney development was normal in Wt1(+/R394W) heterozygotes. However, by 4 months of age 100% of male heterozygotes displayed proteinuria and glomerulosclerosis characteristic of DDS patients. This phenotype was observed in an MF1 background but not in a mixed B6/129 background, suggestive of the action of a strain-specific modifying gene(s). WT1 encodes a nuclear transcription factor, and the R394W mutation is known to impair this function. Therefore, to investigate the mechanism of Wt1 R394W-induced renal failure, the expression of genes whose deletion leads to glomerulosclerosis (NPHS1, NPHS2, and CD2AP) was quantitated. In mutant kidneys, NPHS1 and NPHS2 were only moderately downregulated (25 to 30%) at birth but not at 2 or 4 months. Expression of CD2AP was not changed at birth but was significantly upregulated at 2 and 4 months. Podocalyxin was downregulated by 20% in newborn kidneys but not in kidneys at later ages. Two other genes implicated in glomerulosclerosis, TGFB1 and IGF1, were upregulated at 2 months and at 2 and 4 months, respectively. It is not clear whether the significant alterations in gene expression are a cause or a consequence of the disease process. However, the data do suggest that Wt1 R394W-induced glomerulosclerosis may be independent of downregulation of the genes for NPHS1, NPHS2, CD2AP, and podocalyxin and may involve other genes yet to be implicated in renal failure. The Wt1(R394W) mouse recapitulates the pathology and disease progression observed in patients carrying the same mutation, and the mutation is completely penetrant in male animals. Thus, it will be a powerful and biologically relevant model for investigating the pathobiology of the earliest events in glomerulosclerosis.
Genetic and Environmental Influence on Maize Kernel Proteome (2010)

Comparative targeted compositional analysis is currently an important element in the safety assessment of genetically modified plants. Profiling methods have been suggested as nontargeted tools to improve the detection of possible unintended effects. In this study, the capability of 2-dimensional electrophoresis to detect significant differences among seven conventional maize (Zea mays) cultivars grown in six different locations in Germany during two consecutive seasons was evaluated. Besides maize genotype, both geographic location and season had a significant effect on protein profiles. Differences as high as 55- and 53-fold in the quantity of specific proteins were recorded, the median observed difference being around 6- and 5-fold between the genotypes and growing locations, respectively. Understanding the variation in the quantity of individual proteins should help to put the variation of endogenous proteins and the novel proteins in the genetically modified plants in perspective. This together with the targeted analyses the profiling methods, including proteomics, could also help to get a deeper insight into the unintended alterations that might have occurred during the genetic modification process.
Internal Compression Arthrodesis of the Ankle (1985)

Eight patients with disabling tibiotalar arthritis (one patient with a supramalleolar nonunion) were treated by arthrodesis. The procedure in all of these patients consisted of internal compression obtained by bone plates and the application of a bilateral tension device. A bilateral surgical approach was used. No bone grafting was required. This study compares two groups immobilized for ten and three weeks, respectively. In both groups, the procedure invariably produced union with excellent cosmesis, few complications, and good function.
The effects of repeated doses of keratinocyte growth factor on cell proliferation in the cellular hierarchy of the crypts of the murine small intestine. (2001)

Keratinocyte growth factor (KGF) administered on a daily basis for 3 or more days can result in dramatic changes in tissue architecture, particularly the thickness in oral epithelia, and can afford protection against the cytotoxic effects of radiation on the clonogenic stem cells in the crypts. This protection of intestinal stem cells (increased numbers of surviving crypts) is reflected in an increased survival of animals exposed to a lethal dose of irradiation. The mechanisms underlying these effects are not clear. The present experiments were designed to investigate the nature of any proliferative changes induced in the crypts of the small intestine by protracted exposure to KGF. Tritiated thymidine or bromodeoxyuridine labeling showed statistically significant increases in labeling in the stem cell zone of the crypt, with a concomitant reduction in labeling in the upper regions of the crypt corresponding to the late-dividing transit population. The increase in labeling in the lower regions of the crypt was also observed with Ki-67 staining, but the reduction in the upper regions of the crypt seen with tritiated thymidine was not observed with Ki-67. Metaphase arrest data suggest that the rate of progression through the cell cycle is essentially the same in KGF-treated animals as in controls, but there is a statistically significant increase in the number of mitotic events per crypt. Double labeling studies suggest that, at certain times of the day, there is a greater influx into S phase than efflux. The data overall indicate that KGF induces some complex proliferative changes in the intestinal crypts and are consistent with the hypothesis that the radioprotection may be afforded, at least in part, by a KGF-induced increase in stem cell numbers and/or increases in the number of stem cells in the S phase of the cell cycle. This alteration in the homeostasis of the crypt is compensated for by a foreshortening of the dividing transit lineage.
Correlation between Performances of Hollow Fibers and Flat Membranes for Gas Separation (2017)

This work presents an attempt at correlating the available permeability/selectivity literature data for hollow fibers and flat membranes. Therefore, this paper gathers the information pertaining to membrane materials for which membrane properties of flat membranes and hollow fibers have both been reported. An overview of the relations between selectivity and permeance of hollow fiber membranes for various gas pairs (O2/N2, CO2/CH4, CO2/N2, H2/N2, H2/CO2, H2/CH4 and He/N2) is presented first. The upper bound lines are the ones proposed by Robeson, which were calculated by assuming a one-micron-thick skin layer as proposed by Robeson in 2008. From the results obtained, a relation between the selectivity ratio in both kinds of membranes (αH/αf) and skin layer thickness (l) calculated from flat membranes and hollow fibers gas permeation data for these pairs of gases is also presented. The skin layer thicknesses measured using seven different experimental techniques for six commercial membranes are compared. The influences of spinning parameters on the morphology and performance of hollow fiber membrane gas separation are discussed. Finally, an analysis is made of the reasons why the dense skin layer thicknesses of a hollow fiber calculated using permeance and permeability data vary for different gases and also differ from direct experimental measurements.
Relationship of cravings with weight loss and hunger: Results from a 6 month worksite weight loss intervention (2013)

We examined the association of food cravings with weight loss and eating behaviors in a 6 month behavioral weight loss program conducted in 4 worksites. Assessments included non‐fasting body weight, food cravings (Craving Inventory and Food Craving Questionnaire for state and trait) and eating behavior constructs (Eating Inventory) and were completed by 95 participants. There were statistically significant reductions in all craving variables in the intervention group compared to the controls. Within the intervention group, changes in craving‐trait were significantly associated with weight change after controlling for baseline weight, age, gender and worksite. However, in a multivariate model with craving‐trait and eating behaviors (restraint, disinhibition and hunger), hunger was the only significant predictor of weight change. In contrast to several previous reports of increased food cravings with weight change, this study confirmed a broad reduction in cravings during weight change. In conclusion, reductions in craving‐trait were associated with weight change, but this association not significant when hunger was included in statistical models. Hunger control may directly influence both weight change and food cravings, and studies are needed to examine the effectiveness of hunger suppressing versus craving‐suppressing strategies in behavioral obesity treatment.
Binary Recursive Partitioning Method for Modeling Hot-Stabilized Emissions From Motor Vehicles (1997)

An alternative statistical modeling approach, hierarchical tree-based regression (HTBR), is presented for developing modal correction factors for hydrocarbon (HC) emissions from motor vehicles. The term modal refers to operating modes of vehicle activity such as cruise, idle, deceleration, and acceleration. Explanation of the statistical theory is provided, followed by a presentation of specific modeling results for HCs. The modeling results are based on 4,800 vehicle emissions tests representing 29 laboratory testing cycles. HTBR methods are indicated to overcome statistical difficulties that are problematic for classical ordinary least-squares (OLS) regression, a commonly applied statistical technique for analyzing emissions data. HTBR methods are more adept at treating interactions and monotonic transformations on independent variables, better at handling categorical independent variables with more than two levels, not adversely affected by multicollinearity, and good at capturing nonadditive behavior across the range of independent variables. Unfortunately, HTBR theory is less well developed than OLS regression theory, and statistical parameter properties, such as efficiency, unbiasedness, and consistency, need further development. The HTBR modeling results for HCs are insightful. Hydrocarbon emissions from normal-emitting motor vehicles are most sensitive to changes in power (instantaneous speed 2 ƃ acceleration) requirements of a given driving sequence, while high-emitting vehicles are sensitive to both the amount of idle activity and positive kinetic energy (instantaneous speed ƃ acceleration) in a given driving sequence. Vehicle model year, engine size (cubic centimeters of displacement), curbside weight, and fuel delivery type (fuel injected, throttle body injected, carbureted), also were indicated to influence emission rates. Finally, high- and normal-emitting vehicles are sensitive to different operational and vehicle specific factors.
Investigations of Subcritical Streamer Microwave Discharge in Reverse-Vortex Combustion Chamber (2009)

In this paper, we report on the experimental investigations of two innovative technologies combined in one device, namely, the application of an initiated streamer microwave (MW) discharge for ignition and flame control in a reverse-vortex combustion chamber, also known as a Tornado combustor. The pulsed subcritical streamer MW discharge (SSD) in a quasi-optical wave beam was experimentally investigated in the atmospheric-pressure model of a Tornado combustor with transparent dielectric walls. The possibility of a surface MW streamer discharge formation at new conditions, particularly on the dielectric walls of the cylindrical combustion chamber, has been confirmed. The mechanism of SSD realization, at which the discharge development takes place in a volume of the combustion chamber, has been proposed. It was shown that SSD could be applied for ignition of fuel/air mixtures in an axial area of the reverse-vortex combustion-chamber bottom plate, which is normally used for a fuel feeding.
New Non-cyclic Homo-diterpene from the Sting Glands of<i>Bracon hebetor</i>Say (Hymenoptera: Braconidae) (1990)

Journal Article New Non-cyclic Homo-diterpene from the Sting Glands of Bracon hebetor Say (Hymenoptera: Braconidae) Get access Jun-ichi Fukushima, Jun-ichi Fukushima Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Yasumasa Kuwahara, Yasumasa Kuwahara Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305, Japan To whom all correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Akifumi Yamada, Akifumi Yamada Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Takahisa Suzuki Takahisa Suzuki Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 54, Issue 3, 1 March 1990, Pages 809–810, https://doi.org/10.1080/00021369.1990.10869987 Published: 01 March 1990 Article history Received: 06 September 1989 Published: 01 March 1990
Virtual Transformations: The Evolution of Publication Media (1995)

EXAMINES THE developing publication forms in the electronic environment in the light of recent critical perspectives on textuality, historical dimensions of technological change, and practical considerations of economic and political culture.The article suggests that the book will be significantly altered in the networked future-transformed into something new-but concludes that impediments to change are cultural-not economic or technological.
Reverberation reduction in ultrasonic B-mode images via dual frequency image subtraction (1993)

The authors demonstrate the feasibility of an approach, dual-frequency subtraction imaging, for suppressing artifacts produced by reverberation of strong echoes among specular reflectors. This method is based upon the principle that specularly reflected echoes from flat boundaries are frequency-independent whereas the diffusely scattered echoes from small scatterers are frequency-dependent. The approach was assessed on phantoms including one consisting of two parallel plastic plates between layers of foam sponges using a prototype experimental system. Preliminary results show that this method is superior to simple thresholding techniques or signal compression and holds great promise for suppressing reverberation artifacts in ultrasonic images.
Preparation of BiSrCaCuO Multilayers by Use of Slower Q-switched 266 nm YAG Laser (2001)

Multilayers of Bi 2 Sr 2 Ca 1 Cu 2 O x /Bi 2 Sr 2 Cu 1 O x were prepared by pulsed laser deposition (PLD) using the fourth harmonic 266 nm YAG. Compared to an excimer laser, YAG PLD required the higher oxygen atmosphere. The higher oxygen pressure together with the lower energy generated by YAG laser collapsed the region of plume emission. In order to produce the same energy density as an excimer, only Q-switch was modulated by 2 Hz while the flash lamp kept the original repetition rate of 10 Hz. With the rate of 2 Hz, we obtained the higher energy density per pulse, and more stable laser output of the fourth harmonics, 266 nm. To characterize the multilayers, reflection high-energy electron diffraction (RHEED) and X-ray diffraction (XRD) were employed, and indicative of epitaxial layers with limited in-plane order. The resistivities of multilayers were measured by the Van der Pauw method, and showed the temperatures of superconducting transition, T c0 ( R =0), around 65 K on the multilayers.
Erythromycin. XII.<sup>1</sup> The Isolation, Properties and Partial Structure of Erythromycin C (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTErythromycin. XII.1 The Isolation, Properties and Partial Structure of Erythromycin CPaul F. Wiley, Richard Gale, C. W. Pettinga, and Koert GerzonCite this: J. Am. Chem. Soc. 1957, 79, 22, 6074–6077Publication Date (Print):November 1, 1957Publication History Published online1 May 2002Published inissue 1 November 1957https://pubs.acs.org/doi/10.1021/ja01579a061https://doi.org/10.1021/ja01579a061research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Study of High Temperature Gas Reaction of NO-CH-O<sub>2</sub>(-CO<sub>2</sub>) Mixtures By Means of a Molecular Beam Sampling-Mass Filter System (1979)

Abstract The homogeneous gas phase reaction of NO-CH4-O2(-CO2)-Ar mixtures in high temperature is investigated by means of the molecular beam sampling method. The reaction species NO, CH4, HCN, CO, COk and N2 are quantitatively analyzed with a mass filter system within a limit of 10 ppm. The species resulting from NO reduction are HCN, NH3 and Na. The amount of HCN decreases with an increase in the ratio of O2 to CH4. Both NO reduction and formation of HCN, NH3and N2 are clearly enhanced by the addition of CO2. Conversely, the consumption of O2 is retarded. In these reactions, it appears that oxidation of CH4 initiates the NO reduction and, therefore, HCN, NH3 and N2 are progressively formed. Based on the experimental results, an overall kinetic equation for HCN behavior associated to NO reduction is derived as follows: The effect of CO2 addition on the present reactions is in agreement with a reaction mechanism proposed earlier by Haynes.
HORMONALLY INDUCED MAMMARY GROWTH AND LACTATION IN THE ABSENCE OF THE THYROID (1955)

It has been reported (Lyons and collaborators, 1953 and in press) that the administration of estrone, progesterone, lactogenic hormone and growth hormone to hypophysectomized-gonadectomized rats with or without adrenals induces complete lobulo-alveolar mammary growth, and that after such a regimen lactation may be initiated by continued injections of lactogenic hormone and growth hormone, with the addition of cortisone or hydrocortisone acetate. However, the role of the thyroid was undetermined in these experiments; such animals, since they have been hypophysectomized, can be considered hypothyroidal, but they cannot properly be considered athyroidal. Even when the thyroid has been removed, some residual effect of circulating thyroid hormone may still be evident for several weeks postoperatively, and furthermore, complete surgical removal of all visible thyroid tissue from the adult rat never warrants the assumption that no thyroid tissue remains. In recent years radio-iodine, which has been used to test the completeness of surgical thyroidectomy (Reinhardt, 1942),
Eisen-Silicium-Legierungen mit höheren Siliciumgehalten als Werkstoffe für die Elektrotechnik (1976)

Wirtschaftliche Bedeutung der Ummagnetisierungsverluste in Elektroblechen. Konstitution und mechaniches Verhalten der kubisch-raumzentrierten Eisen-Silicium-Kristalle. Herstellung und magnetische Eigenschaften von Elektroblechen mit 6% Si. Erprobung an einer elektrischen Maschine. Economic importance of the magnetic losses in electric sheets. Constitution and mechanical properties of the body-centered cubic iron-silicon crystals. Manufacture and magnetic properties of electric sheets with 6% Si. Testing on an electric machine. L'importance économique des pertes magnétiques dans des tôles électriques. Constitution et propriétés mécaniques des cristaux de fer-silicium cubiques centrés. Fabrication et propriétés magnétiques de tôles électriques à 6% de Si. Essais sur une machine électrique.
Reaction of the Hydroxyl Radical with Phenol in Water Up to Supercritical Conditions (2007)

The rate constants for the reactions of phenol with the hydroxyl radical (OH*) in water have been measured from room temperature to 380 degrees C using electron pulse radiolysis and transient absorption spectroscopy. The reaction scheme designed to fit the data shows the importance of an equilibrium, giving back reactants (OH* radical and phenol) from the dihydroxycyclohexadienyl radical formed by their reaction, and the non-negligible contribution of the hydroxycyclohexadienyl radical absorption from H* atom addition. The accuracy of the reaction scheme and the reaction rate constants determined from it have been determined by the analysis of two different experiments, one under pure N2O atmosphere and the second under a mixture a N2O and O2. We report reaction rates for the H* and OH* radical addition to phenol, the formation of phenoxyl, the second-order recombination, the reaction of dihydroxycyclohexadienyl with O2, and the decay of the peroxyl adduct. Nearly all of the reaction rates deviate strongly from Arrhenius behavior.
Using fractional differentiation for the modeling of 1/f/sup 1/ noise application to discrete-time noise sources in VHDL-AMS (2004)

This paper proposes a method for the behavioral modeling of 1/f/sup 1/ noise sources, dedicated to time domain simulations. This method is theoretically based on fractional differentiation. The behavioral models are implemented in VHDL-AMS. As an illustration, examples of basic noise voltage sources (white and 1/f noise) are given and analyzed. The concept is then re-used to simulate noise effects on a sigma-delta modulator.
Studies on the Glycolipid Content of the Cyanobacterium<i>Fischerella ambigua</i> (1995)

A series of monogalactosyl diacylglycerols was isolated from lipophilic extracts of Fischerella ambigua. These glycolipids were identified on the basis of chemical and spectroscopic analyses.
Central venous pressure: we need to bring clinical use into physiological context (2015)

The correct measurement of CVP is pivotal to its proper clinical application. This relates to defining the pressure gradient for venous return and heart efficiency. The clinical appreciation of CVP should be restored by educational efforts of its physiological context.