gebhart/patrepeval huggingface dataset:
The putative iron-responsive element in the human erythroid 5-aminolevulinate synthase mRNA mediates translational control (1993)

The 52-nucleotide 5'-untranslated region of the human erythroid 5-aminolevulinate synthase mRNA contains a 28-nucleotide iron-responsive element-like stem-loop motif. We fused the 5'-untranslated region upstream to the coding sequence of the human growth hormone cDNA. A chimeric construct containing a mutated variant of the presumptive iron-responsive element was similarly synthesized. Translation of the wild type chimeric transcript was markedly repressed (approximately 95%) in rabbit reticulocyte lysates as opposed to the mutant. Both transcripts translated with comparable efficiency in wheat germ extracts. Purified placental iron regulatory factor selectively and markedly inhibited translation of the wild type chimeric transcript (> 90%) when tested in wheat germ extracts. By contrast, translations of either the mutant chimeric transcript or other control mRNA species were unaffected. The proximal position of the iron-responsive element relative to the cap site was shown to be important for translational control, in vitro. Our studies suggest that interaction of the iron regulatory factor with the iron-responsive element sterically hinders formation of the preinitiation complex, resulting in translational repression. Thus inactivation of the repressor protein by critical levels of iron or heme would trigger translation of this mRNA in erythroid cells. Consequently, protoporphyrin and heme synthesis would be subtly coordinated with iron supply.
Synchronization for QPSK Transmission via Communications Satellites (1980)

Carrier phase and symbol timing synchronization performances are determined for QPSK transmission over the nonlinear communications satellite channel with several typical modem filtering configurations. A computer simulation is used that models conventional or offset QPSK transmission, the modem filters, the nonlinear satellite TWTA, and the receive modem synchronizers. These simulations are used to obtain errors in carrier phase and symbol timing estimates caused by both thermal noise and the modulation-pattern-induced jitter. The statistics of these errors are obtained for several channel filtering combinations and TWTA backoff levels. These experiments are extended to examine the overall effect of synchronization errors on bit-error probability for one particular implementation of the synchronizers.
Degradability of cellulose acetate (1.7 D.S.) and cellophane in anaerobic bioreactors (1992)

The objects of this study were to simulate methanogenic conditions in the degradation of a synthetic MSW(SMSW) mixture using serum bottle techniques, and to measure the degradability of selected plastics during anaerobic fermentation. In addition, the developed technology described here for the study of anaerobic degradability of plastics during digestion of SMSW is meant to be useful as a reproducible procedure which may be considered by other researchers.
Attenuated Salmonella Typhimurium Carrying TRAIL and VP3 Genes Inhibits the Growth of Gastric Cancer Cells in Vitro and in Vivo (2010)

Delivery of TRAIL and VP3 genes by attenuated S. typhimurium can significantly inhibit the growth of gastric cancer cells in vitro and in vivo.
The benefit of borehole gravity in horizontal monitoring wells for time-lapse applications (2012)

In this paper, we present a study on the added benefit of jointly inverting surface and borehole gravity data for reservoir monitoring. In particular, we show that time-lapse measurements in horizontal monitoring wells can provide significant additional information about fluid movement over surface data alone. The primary advantage of such monitoring wells lies in the option to preferentially orient them with the geometry of a production or sequestration field. Additionally, well heights can be chosen to maximize the signal strength in consideration of instrument accuracy, while balancing data sensitivity to the lateral extent of the reservoir to be monitored. We demonstrate this study using a realistic representation of a difficult CO2 EOR site and the joint interpretation of surface and borehole data with highly constrained inversion.
Multiuser Spectrum Optimization for Discrete Multitone Systems With Asynchronous Crosstalk (2007)

Finding computationally efficient spectrum optimization methods for a multiuser digital subscriber line (DSL) environment is a key objective of dynamic spectrum management for DSL systems. For synchronous discrete multitone (DMT) based DSL systems, the computational complexity issue can be partially addressed using a dual optimization approach that decomposes the problem in the frequency domain. However, the decomposition approach fails whenever the DMT system is asynchronous, in which case the power allocations in adjacent frequency tones interfere with each other. This paper provides a mathematical model for intercarrier interference due to symbol misalignment and proposes ways to modify the dual method for spectrum optimization of asynchronous DSL systems. The main ingredient of the algorithm is an efficient method to evaluate the minimum power required to support a given bit-allocation using a power series approximation, combined with a local gradient search.
Late events in B cell activation. Expression of membrane alkaline phosphatase activity. (1989)

Alkaline phosphatase (APase) has been previously described as a membrane marker correlating with B cell proliferation after stimulation by selected B cell mitogens. We have found, however, that the appearance of B cell membrane APase correlates more closely with differentiation than with proliferation. This conclusion has been drawn from the following observations: 1) APase activity appears well after peak B cell thymidine uptake, 2) mitogens which stimulate only B cell proliferation (Salmonella typhimurium mitogen) fail to induce expression of the enzyme, and 3) when proliferation of mitogen-activated B cells is inhibited, APase activity is not suppressed and may even be augmented. In addition to membrane expression, APase is also spontaneously shed into the surrounding milieu, perhaps as a result of endogenous phospholipase activity. By using a group of well-characterized inhibitors, the APase activity was shown to belong to class I (similar to the bone/liver/kidney class). Because APase always appears in differentiating but not proliferating cells, we would propose that the enzyme appearance is a late marker of B cell activation, associated with cell progression to differentiation and consequent IgM synthesis.
Student Volunteers in Academic Libraries (2012)

Volunteers have contributed successfully to the work of public and school libraries since time immemorial and there are many examples of libraries, especially for patients in hospitals which would ...
Side of onset of motor symptoms and cognitive functioning in Parkinson's disease (2012)

<p><strong>Objective:</strong> While lateralisation of cognitive functions at a cortical level is well described, less is known about sub-cortical lateralisation. Parkinson’s disease (PD) is a degenerative, sub-cortical neurological disorder characterised by a large number of motor and non-motor symptoms. The non-motor symptoms range from mild cognitive impairment to PD dementia, while the cardinal motor symptoms include muscle rigidity, tremor, bradykinesia, loss of postural reflexes and akinesia. These motor symptoms initially present unilaterally or bilaterally. The aim of the current study was to investigate sub-cortical lateralisation of cognitive functioning by examining possible links between the lateralisation of onset of motor symptoms and subsequent cognitive decline.</p> <p><strong>Participants and Methods:</strong> 50 participants with idiopathic PD were recruited from the Royal Hobart Hospital outpatient clinic and assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Trail Making Test, and the National Adult Reading Test (NART). Side of motor symptom onset information was also recorded.</p> <p><strong>Results:</strong> Participants were split into three groups; right, left, and bilateral motor symptom onset and initial analyses indicated no significant age or pre-morbid IQ (NART) differences. One-way ANOVAs with Tukey’s post-hoc measures were used to detect significant differences between the three groups. Significantly lower scores were found for the right-side motor onset group on the digit span task (<i>p</i> = .013), and for the left-side motor onset group on the figure copy task (<i>p</i> = .008) and for the overall RBANS Visuospatial/Constructional index score (<i>p</i> = .004). In addition to this, the results, while not significant, trend towards suggesting increased impairment effects across most tasks for patients with bilateral symptom onset.</p> <p><strong>Conclusion:</strong> PD patients with right side motor symptom onset are likely to experience greater difficulties with left hemisphere specific tasks, while patients with left side motor symptom onset are likely to experience greater difficulties with right hemisphere specific tasks. These results indicate that there is some sub-cortical lateralisation of cognitive functions to mirror that which has already been demonstrated at the cortical level. Further research associated with this study will examine specific measures of motor functioning using a finger tapper and hand dynamometer. Additional research should investigate a wider range of cognitive functions. </p>
Boronic Acids and Esters in the Petasis-Borono Mannich Multicomponent Reaction (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTBoronic Acids and Esters in the Petasis-Borono Mannich Multicomponent ReactionNuno R. Candeias*†‡, Francesco Montalbano†, Pedro M. S. D. Cal†, and Pedro M. P. Gois†View Author Information iMed.UL, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal., The Skaggs Institute for Chemical Biology and Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037* To whom correspondence should be addressed. E-mail: [email protected]†Faculdade de Farmácia da Universidade de Lisboa.‡The Scripps Research Institute.Cite this: Chem. Rev. 2010, 110, 10, 6169–6193Publication Date (Web):August 2, 2010Publication History Received8 April 2010Published online2 August 2010Published inissue 13 October 2010https://pubs.acs.org/doi/10.1021/cr100108khttps://doi.org/10.1021/cr100108kreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views15932Altmetric-Citations456LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Amines,Chemical reactions,Reaction products,Solvents Get e-Alerts
[Gelatin resorcin formaldehyde glue in vascular surgery (author's transl)]. (1977)

The use of this biological glue appeared to us to be of particular interest in the surgical treatment of dissecting aneurysms of the aorta. An experimental investigation revealed its hemostatic and adhesive properties, and demonstrated its merit when used as material in vascular embolization.
VR 플랫폼을 활용한 웹드라마 스토리텔링 연출에 대한 연구 (2018)

최근 영상콘텐츠에서는 VR플랫폼을 어떻게 활용할 수 있을지 주목하고 있다. 이에 본문에서는 웹툰, 2D웹드라마, VR웹드라마라는 세 개의 플랫폼을 활용한 브랜디드 콘텐츠 을 가지고 VR을 활용했을 때 어떠한 방식으로 웹드라마를 연출할 수 있을지 살펴보았다. 동일한 내용으로 웹툰, 2D와 VR 웹드라마로 제작된 이 콘텐츠에서...
Role of ethylenediamine in the preparation of alumina-supported Ni catalysts from [Ni(en)2(H2O)2](NO3)2: from solution properties to nickel particles (2003)

A Ni 0 (15 wt %)/Al 2 O 3 catalyst is prepared by impregnation using [Ni(en) 2 (H 2 O) 2 ](NO 3 ) 2 as precursor salt containing the chelating ligand ethylenediamine (en). Due to the low solubility of this salt and the high viscosity of its solution, large crystals of the salt deposit on the support, clogging the porosity of alumina. These crystals split during the thermal treatment in argon; hydrogen produced in situ from organic residues reduces quantitatively nickel (II) to monodisperse small Ni 0 particles, compared with only one half of nickel reduced by hydrogen when catalysts are prepared from [Ni(H 2 O) 6 ](NO 3 ) 2 .
Performance Evaluation Metrics for Information Systems Development: A Principal-Agent Model (1992)

The information systems (IS) development activity in large organizations is a source of increasing cost and concern to management. IS development projects are often over-budget, late, costly to maintain, and not done to the satisfaction of the requesting user. These problems exist, in part, due to the organization of the IS development process, where information systems development is typically assigned by the user (principal) to a systems developer (agent). These two parties do not have perfectly congruent goals, and therefore a contract is developed to specify their relationship. An inability to directly monitor the agent requires the use of performance measures, or metrics, to represent the agent's actions to the principal. The use of multiple measures is necessary given the multi-dimensional nature of successful systems development. In practice such contracts are difficult to develop satisfactorily, due in part to an inability to specify appropriate metrics. This paper develops a principal-agent model that provides a set of decision criteria for the principal to use to develop an incentive compatible contract for the agent. These criteria include the precision and the sensitivity of the performance metric. After presenting the formal model, some current software development metrics are discussed to illustrate how the model can be used to provide a theoretical foundation and a formal vocabulary for performance metric analysis. The model is also used in a positive (descriptive) manner to explain why current practice emphasizes metrics that possess relatively high levels of sensitivity and precision. Finally, some suggestions are made for the improvement of current metrics based upon these criteria.
Online Synchronous Versus Asynchronous Software Training via Behavioral Modeling Approach (2011)

The continued and increasing use of online training raises the question of whether the most effective training methods applied in live instruction will carry over to different online environments in the long run. Behavior modeling (BM) approach—teaching through demonstration—has been proven as the most effective approach in a face-to-face (F2F) environment. A quasi-experiment was conducted with 96 undergraduate students who were taking a Microsoft SQL Server 2000 course in a university in Taiwan. The BM approach was employed in three learning environments: F2F, online synchronous and online asynchronous classes. The results were compared to see which produced the best performance, as measured by knowledge near-transfer and knowledge far-transfer effectiveness. Overall satisfaction with training was also measured. The results of the experiment indicate that during a long duration of training no significant difference in learning outcomes could be detected across the three learning environments.
Hamster sperm glycine receptor: Evidence for its presence and involvement in the acrosome reaction (2000)

Recent reports have provided evidence for the presence of amino acid neurotransmitter receptor/chloride channels in human and porcine spermatozoa and their involvement in the acrosome reaction (AR). In this work we investigated whether a glycine receptor (GlyR) was present in golden hamster sperm, and whether it had a role in the hamster AR. The neuronal GlyR agonist glycine, stimulated in a dose-dependent manner, the AR of hamster spermatozoa previously capacitated for at least 3 hr. This stimulation was completely inhibited by 50 microM (+)-bicuculline and by concentrations of strychnine as low as 10-50 nM; both agents are antagonists of neuronal GlyR when used at the concentrations reported in this study. beta-Alanine, another agonist of the neuronal GlyR, also stimulated the AR. The AR-stimulatory effect of this compound was completely abolished by 50 nM strychnine. The inhibitory effect of strychnine on the glycine-induced hamster sperm AR was completely overcome by subsequent treatment with the calcium ionophore ionomycin, demonstrating that the strychnine effect was specific for GlyR. Additional binding studies with (3)[H]-strychnine, the typical radioligand used to detect GlyR in several cells, demonstrated for the first time the presence of specific binding sites for strychnine in the hamster spermatozoa. Interestingly, binding increased during in vitro capacitation, particularly in those sperm suspensions showing high percentages of AR. Taken together these results strongly suggest the presence of a GlyR in the hamster spermatozoa, with a role in the AR when activated.
Theory of the Temperature Derivative of the Refractive Index in Transparent Crystals (1973)

A simplified model is introduced to study the temperature dependence of the index of refraction $n$ in the transparent regime of crystals. The dielectric susceptibility is written as a sum of an electronic contribution due to band-to-band transitions and a lattice contribution, viewed as due to a single mode ${\ensuremath{\omega}}_{0}$ Each of the latter undergoes a temperature variation consisting of contributions due to thermal expansion, as well as contributions due to the explicit temperature dependence at constant volume. The temperature derivative $\frac{\mathrm{dn}}{\mathrm{dT}}$ is investigated for various materials. It is found that for zinc-blende- and diamond-type semiconductors, electronic effects, in particular the temperature variation of the band gap at constant volume, yield the dominant contribution. Theoretical calculations of the latter are carried out employing a temperature-dependent-pseudopotential band-structure model; the resulting values for $\frac{\mathrm{dn}}{\mathrm{dT}}$ are in good agreement with experiment. For ionic materials, it is found that both lattice and electronic contributions may be important, as are both explicit temperature variation and thermal-expansion effects. Experimental data on the temperature dependence of ${\ensuremath{\omega}}_{0}$ and the band gap are employed to obtain good agreement with the frequency variation of $\frac{\mathrm{dn}}{\mathrm{dT}}$ for a variety of ionic crystals. The results demonstrate that the major physical mechanisms responsible for $\frac{\mathrm{dn}}{\mathrm{dT}}$ can be understood within the present simplified model, and that the model is useful in predicting the magnitude and frequency dependence of $\frac{\mathrm{dn}}{\mathrm{dT}}$ for a wide variety of crystals of interest.
Excessive Breast Self-Examination Among First-Degree Relatives of Newly Diagnosed Breast Cancer Patients (1997)

First-degree relatives (FDRs) of women with breast cancer may have heightened anxiety about their personal risk for developing breast cancer. Breast self-examination (BSE) is an important component of risk surveillance for all women. In this study, the authors describe a subset of FDRs who appear to excessively (> or = once per day) perform BSE. These women, who constituted 8% of 1,053 FDRs in this study, were compared with women who did not examine excessively. The excessive self-examiners were older, more frequently African American, and less educated. They were more likely to have an affected daughter and > or = two FDRs with breast cancer. They were significantly more likely to think frequently about breast cancer and to report that such thoughts affected their mood. In a multivariate analysis, three variables had significant independent associations with excessive BSE practice: ethnicity (odds ratio [OR] = 2.3), perceived risk of breast cancer compared with women without a family history (OR = 2.9), and frequency of thoughts about breast cancer (OR = 5.5). The women who practice excessive BSE would benefit from enhanced educational efforts and screening for the presence of psychiatric problems such as anxiety and hypochondriasis.
Empirical Study of Corporate Governance on Public Listed Companies in Malaysia (2017)

The purpose of this study is to examine the relationship between corporate governance and non-technology firm performance. The empirical data on 14 public listed companies (PLCs) in Malaysia that is observed for year 2010-2014. The data was analyzed by using the simple linear and hierarchical regression analysis. Findings shown that there is a positive relationship between corporate governance and firm performance. Concludes that involvement and commitment are considered to be important characteristics that improves the firm performance for the firm’s performances. It’s become importance of corporate governance involvement on improving firm performance. Therefore, in order to achieve the Eleventh Malaysia Plan (2016-2020) targets and goals which includes strengthening the corporate governance mechanism, and strengthening the industry-academia collaboration. It is important for the board of directors to be involved to ensure effective and efficient decisions making. This would help increase the overall firm’s activities and performance in Malaysia.
<title>Design of an achromatic mass separator for a focused-ion-beam system</title> (1993)

The design of an achromatic mass separator which consists of two ExB filters, a stigmator, and the separation aperture is described. The optical properties of the ExB filters are derived. The influence of the designed mass separator on the spatial resolution of the column and the fringing field effects are discussed. First experimental results are shown.
Optimising the blocking efficiency in shaped Cassegrain systems (1968)

The blocking efficiency of a Cassegrain antenna system can be improved considerably by shaping the main and the subreflector in such a way that the power, which is normally lost by scattering against the blocking obstacles, arrives at the aperture in the correct phase and direction and with the correct amplitude. It is explained that shadows of (nearly) spherical waves on the aperture can be made to disappear entirely. A practical example is described.
Review on Atomic Layer Deposition and Applications of Oxide Thin Films (2013)

Atomic layer deposition technique is able to grow conformal thin films over high aspect ratio structures. This article reviews the various aspects of oxides grown by this method including applications in photovoltaics and memristors. The main focus of this review is to concentrate on the oxides grown by atomic layer deposition and their growth mechanisms. The oxides deposited using atomic layer deposition are also likely to find application in memristor, an emerging field in the non volatile memories design with the ability to retain data and memory states even in power-off condition. The use of this technique to obtain oxides in surface modification of nanostructures gives the significance of these materials.