gebhart/patrepeval huggingface dataset:
Relational mapping ofMYCN andDDX1 in band 2p24 and analysis of amplicon arrays in double minute chromosomes and homogeneously staining regions by use of free chromatin FISH (1997)

MYCN amplification has been observed in diverse neuronal tumors including neuroblastoma, retinoblastoma, and small cell carcinoma of the lung, and has been correlated with a poor prognosis in advanced-stage neuroblastomas. Recent studies have shown a co-amplification of DDXI, a DEAD box gene, and MYCN in retinoblastoma and neuroblastoma. DDXI has been mapped to within a megabase of the MYCN gene in band 2p24. In the present study, the relational map of DDXI and MYCN by fluorescence in situ hybridization (FISH) mapping to metaphase cells and extended free chromatin fibers indicated that DDXI is telomeric to MYCN. Dual-color FISH analysis of amplicons within arrays of extended chromatin fibers was performed to examine the physical relationship of MYCN and DDXI within double minute chromosomes (dmins) and homogeneously staining regions (hsrs). No regular reiterated amplicon repeat unit was present in the hsrs, but detailed analysis of the configurations of DDXI and MYCN within each array indicated that multiple rearrangements generated a complex hsr amplicon structure. Similarly, analysis of a cell line bearing dmins showed that a composite amplicon structure involving deletions and/or duplications of MYCN and DDXI is a feature of dmin formation. These data are consistent with a molecular mechanism involving many rearrangements during the evolution of gene amplification, resulting in complex amplicon structures with distinct changes in relative gene copy number and considerable variation in intragenic distances between coamplified genes.
Thoracic Duct Embolization with Lipiodol for Chylothorax due to Thoracic Endovascular Aortic Repair with Debranching Procedure (2015)

Chylothorax is a rare postoperative complication of a thoracic surgical procedure. Here, we report a case of chylothorax after thoracic endovascular aortic repair with debranching for the distal arch aneurysm of the aorta. First, the patient was treated by a medical method (nil per os, fat-free diet, and octreotide), but this method failed. The patient strongly refused surgical treatment. Therefore, we tried to occlude the thoracic duct by lymphangiography Lipiodol, and this line of treatment was successful.
Reactive Scattering in Crossed Molecular Beams. K Atoms with CH3I and C2H5I (1961)

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Crystallization Process Development of an Active Pharmaceutical Ingredient and Particle Engineering via the Use of Ultrasonics and Temperature Cycling (2003)

Process development of a Bristol-Myers Squibb drug substance candidate involved the development of crystallization and particle engineering protocols to address polymorphism, oiling out, and particle size control issues. Two monotropic polymorphs were evaluated, and one was determined to be thermodynamically more stable. The oiling problem was solved by adjusting the polarity of the solvent system and conducting controlled nucleation at low supersaturation. Two protocols were developed to produce the desired form consistently in high quality and yield with a short processing time. Slow crystallization was required to ensure product quality since the final crystallization served as an important purification step, but slower crystallization led to larger crystals. To avoid dry milling, ultrasound was used for particle size reduction in the crystal slurry post-crystallization. Temperature cycling followed for particle size uniformity. The scale-up involved use of an ultrasonic tube through which the crystal slurry was passed continuously. The protocol was successfully executed in multikilogram-scale GMP batches.
At The Moving Picture Ball : A Photo-Play In 2 Reels (1920)

1 vocal score (3 p.) ; 27 cm. Illustrated cover with drawn images of Mary Pickford, Charles Chaplin, Douglas Fairbanks, Roscoe "Fatty" Arbuckle, and others.
Lymphocutaneous Fistula Following Renal Transplantation (1980)

A patient is described in whom the postoperative management after renal transplantation was complicated by a wound discharge. A radionuclide technique of solving the clinical dilemma is discussed, using scintilymphangiography and qualitative assays.
Dalfampridine Treatment in Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) (P5.202) (2017)

To assess whether dalfampridine can improve visual function in patients with NAION over 6 months out.
Energy in the Kentucky economy (1975)

Recent energy shortages revealed the need to assess Kentucky's energy capability and to develop policies for fuel allocation. Employment levels during the 1973 embargo were better than the national average. A Btu surplus allows Kentucky to export energy (mostly coal) to other states. Converting from other energy sources to coal can be handled by the utilities and a majority of industries, but is not likely for household and commercial use or transportation. Conservation could provide a 15% cushion for service industries and a 2% cushion for manufacturing. Principal energy intensive industries (primary metals and chemical products) would suffer most from fuel shortages. An input-output model has been constructed to show energy needs for an optimistic, status quo, and declining economy. Tables listing, by industry, dollar output and employment reduction with a $1,000 reduction in petroleum show that allocating fuel to maintain employment levels will gain maximum economic benefit. Priorities could be based on the nature of the industry (e.g., health and education would have higher priority than the amusement industry). (46 references) (DCK)
Dysbindin and <i>D</i>-Amino-Acid-Oxidase Gene Polymorphisms Associated with Positive and Negative Symptoms in Schizophrenia (2009)

The present association of dysbindin SNPs with negative symptoms and DAO SNPs with anxiety and depression is a replication of earlier findings and strengthens the hypothesis of a genetic association. It further indicates involvement of glutamate abnormalities in schizophrenia pathophysiology, as suggested by previous studies, and suggests that polymorphisms may be associated with subgroups of clinical characteristics in schizophrenia.
Synthesis of N,N′‐[methyl‐<sup>14</sup>C]‐dimethylhydrazine of high specific activity (1982)

Abstract N,N′‐[Methyl‐ 14 C]‐dimethylhydrazine dihydrochloride (2) having a specific activity of 112.5 mCi/mmol was prepared in two steps from ethyl hydrazinedicarboxylate ( ) in dry THF and 14 C‐methyl iodide with a specific activity of approximately 58 mCi/mmol. Methylation of following treatment with KOEt and subsequent hydrolysis of the intermediate ethyl N,N′‐[methyl‐ 14 C]‐ dimethylhydrazinedicarboxylate () in conc. HC1 afforded in 64% yield following purification by thin layer chromatography.
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome (2009)

Factor H autoantibodies have been reported in approximately 10% of patients with atypical hemolytic uremic syndrome (aHUS) and are associated with deficiency of factor H-related proteins 1 and 3. In this study we examined the prevalence of factor H autoantibodies in the Newcastle cohort of aHUS patients, determined whether the presence of such autoantibodies is always associated with deficiency of factor H-related proteins 1 and 3, and examined whether such patients have additional susceptibility factors and/or mutations in the genes encoding complement regulator/activators. We screened 142 patients with aHUS and found factor H autoantibodies in 13 individuals (age 1-11 years). The presence of the autoantibodies was confirmed by Western blotting. By using multiplex ligation-dependent probe amplification we measured complement factor H-related (CFHR)1 and CFHR3 copy number. In 10 of the 13 patients there were 0 copies of CFHR1, and in 3 patients there were 2. In 3 of the patients with 0 copies of CFHR1 there was 1 copy of CFHR3, and these individuals exhibited a novel deletion incorporating CFHR1 and CFHR4. In 5 patients mutations were identified: 1 in CFH, 1 in CFI, 1 in CD46, and 2 in C3. The latter observation emphasizes that multiple concurrent factors may be necessary in individual patients for disease manifestation.
Integration of an electromagnetic coupled sensor into a driver seat for vital sign monitoring: Initial insight (2017)

In this paper, we present the results of an initial study for non-contact vital sign monitoring of a driver using a gradiometer coil integrated into a driver seat. For first evaluation, electromagnetic coupling is analyzed and signal quality is tested in laboratory environment: The sensor is based on the principle of magnetic induction measurement (MIM) but designed to have high influence of capacitive and mechanical coupling as well. The resulting signal is exemplary analyzed and indicates that the sensor is capable of measuring respiratory activity while the driver is in a resting phase like autonomous or highway driving. In the absence of respiratory activity, heart beats can be identified, but have a low signal-to-noise-ratio (SNR) and need to be extracted by further signal processing. In the simulated driving situation using a gaming steering wheel in a racing situation with force feedback, high artifacts are induced due to movement. The results suggest that the distortion in the signal while steering has a distinctive signal course and a steer angle sensor could be of use for artifact removal. Furthermore, the proposed sensor could be used for driver activity monitoring in driver state estimation.
An experimental and theoretical study of the mean diurnal variation of O<sup>+</sup>, NO<sup>+</sup>, O<sub>2</sub><sup>+</sup>, and N<sub>2</sub><sup>+</sup> ions in the mid‐latitude <i>F</i><sub>1</sub> layer of the ionosphere (1979)

Over the past decade, several models have been developed which describe the diurnal behavior of molecular and atomic ions in the altitude range where the atomic and molecular densities are comparable. However, no complete set of diurnal measurements has been available in the past with which to compare these theoretical results, because the altitude regime (130–220 km) lies below the reach of conventional satellites and rocket results give only a transient picture. The Atmosphere Explorer C, D, and E satellites have been taking measurements of ion concentrations together with related aeronomic parameters in the thermosphere for over 4 years. These data have been analyzed to extract the average diurnal variation (i.e., for solar zenith angles less than 105°) of the ion species NO + , O 2 + , N 2 + , and O + as functions of altitude. The AE data have been used in a number of separate studies which have reduced the uncertainties associated with key reaction rate coefficients. As a test of the overall consistency of the photochemistry of the F 1 layer we compare the measured ion concentrations with those calculated by using a model which incorporates our latest understanding of the chemistry and which uses, as input parameters, the measured neutral concentrations and temperature, the solar extreme ultraviolet flux, and electron and ion temperatures. The results show that a fairly simple model, in which the free parameters are minimized, reproduces the measurements to a satisfactory degree.
A new enhanced SPFD rewiring algorithm [logic IC layout] (2003)

This paper presents an in-depth study of the theory and algorithms for the SPFD-based (set of pairs of functions to be distinguished) rewiring, and explores the flexibility in the SPFD computation. Our contributions are in the following two areas: (1) We present a theorem and a related algorithm for more precise characterization of feasible SPFD-based rewiring. Extensive experimental results show that for LUT-based FPGAs, the rewiring ability of our new algorithm is 70% higher than SPFD-based local rewiring algorithms (SPFD-LR) and 18% higher than the recently developed SPFD-based global rewiring algorithm (SPFD-GR). (2) In order to achieve more rewiring ability on certain selected wires used in various optimizations, we study the impact of using different atomic SPFD pair assignment methods during the SPFD-based rewiring. We develop several heuristic atomic SPFD pair assignment methods for area or delay minimization and show that they lead to 10% more selected rewiring ability than the random (or arbitrary) assignment methods. When combining (1) and (2) together, we can achieve 38.1% higher general rewiring ability.
W03I Development of stress memory patch(International Workshop on "New Frontiers of Smart Materials and Structural Systems") (2006)

A new sensing method called "smart stress memory patch", which could estimate the maximum stress, the stress amplitude and the fatigue cyclic number simultaneously using Kaiser effect of Acoustic Emission (AE) and crack length of this patch, was developed. In this study, the crack growth characteristic of this patch was evaluated. Pure copper was used for this patch because its good corrosion resistance, stable crack propagation and so on. Two kinds of samples which were rolled and electrodeposited copper were prepared to investigate the effect of microstructure on crack growth behavior. Fatigue test was performed under constant stress amplitude to evaluate the crack growth behavior using the relationship between stress intensity factor range and crack propagation rate. The scattering in fatigue crack growth was also investigated to obtain the relationship between crack length and the fatigue cyclic number including two-sided 95% confidence interval. The effect of thickness and grain size on the scattering was discussed. Finally, good crack growth behavior was obtained and the fatigue cyclic number could be estimated by this patch.
Space shuttle main engine model identification (1990)

System identification techniques are used to represent the dynamic behavior of the SSME (space shuttle main engine). The comparison of the responses of a nonlinear simulation with the responses of an identified model indicates very good agreement. The identified model can be used for control design purposes. The identified model does not include valve linkage backlash and valve stiction nonlinearities. These nonlinearities should be added to the identified model, and the validity of the model should be checked by comparing it with the full nonlinear simulation. The identified model is valid for a limited response region at about the 100% power level operating condition.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
EVIDENCE THAT CYCLOPHOSPHAMIDE IS A STRONG INHIBITOR OF HUMAN B CELL PROLIFERATION (1987)

This work was supported by grants 05.02 and 05.03 from the Polish Academy of Sciences.
THE BACTERICIDAL ACTION OF PROPYLENE GLYCOL VAPOR ON MICROORGANISMS SUSPENDED IN AIR (1943)

A study of the conditions which affect the bactericidal action of propylene glycol vapor on air-suspended microorganisms has been carried out. The killing process was found to be more effective when both the total number of air-borne droplets and the number of organisms in the bacterial suspension are small. A temperature below 80 degrees F. and an atmospheric relative humidity between 45 and 70 per cent were found to constitute the most favorable conditions for the lethal action of the vapor. Experiments were performed to test the bactericidal efficiency of propylene glycol vapor in both small and large enclosed spaces. These studies revealed that equally marked bactericidal action is obtained when propylene glycol is dispersed in an 800 cubic foot room as occurs in chambers of 2 cubic foot capacity. The susceptibility to vapor action of bacteria re-suspended in saliva was just as great as when broth was used as the suspending medium. Both partially and completely dehydrated bacteria also succumbed to the effects of the vapor. However, when unsterile dust collected from inhabited rooms was dispersed into the air, little reduction of the natural microbic population contained in this material was observed. Data are presented showing the minimum glycol concentration necessary for effective bactericidal action on various microorganisms. Pneumococci were killed by amounts of propylene glycol as low as 1 gm. in 20 million cc. of air. Concentrations of 1 to 5 million to 1 to 10 million were required to produce the same degree of killing of streptococci and staphylococci. The observations here reported add further support to the previously proposed conception of the mechanism of the lethal action of propylene glycol vapor, namely, that a bactericidal concentration of the glycol accumulates in the bacterial droplet as a result of contact with and absorption of glycol molecules from the surrounding atmosphere.
THE TREATMENT OF PNEUMOCOCCIC PNEUMONIA WITH ORALLY ADMINISTERED PENICILLIN (1945)

Several group's of investigators have demonstrated that it is possible to attain appreciable concentrations of penicillin in the blood following the oral administration of the material in various vehicles.<sup>1</sup>In a previous communication<sup>2</sup>it was reported that the height and duration of the blood penicillin concentrations observed in fasting subjects after oral administration are of the same order of magnitude regardless of whether the penicillin is administered following an antacid,as a suspension in oil, as a suspension in oil mixed with beeswax or in plain water. With any of these methods approximately five times as much penicillin is required to achieve a given blood concentration when the material is administered by the oral as by the intramuscular route. From the studies of urinary excretion there was no evidence that any of the vehicles promoted the absorption of more penicillin than occurred following the ingestion of the material in
Stability and Migration of Metal Ions in G4-Wires by Molecular Dynamics Simulations (2006)

We present a molecular dynamics investigation of guanine quadruple helices based on classical force fields. We analyze the dependence of the helical conformation on various compositional factors, such as the length of the G4-wire, as well as the incorporation into the helix channel of alkali ions of different species and in different amounts. In compliance with previous indications, our results suggest that monovalent alkali cations assist the stability of the quadruplex arrangement against disruption on the few nanoseconds time scale in the order of increasing van der Waals radius. Whereas very short G4-wire fragments immediately unfold in the absence of coordinating metal ions or in the presence of tiny ions (e.g., Li+) in agreement with the experimental evidence that empty short guanine quadruplexes are not formed in any synthetic conditions, our simulations show that longer empty helices do not discompose. This finding supports the possibility of producing long G4-wires with different guanine-cation stoichiometries than those routinely known. The classical trajectories allow us to identify different stationary axial sites for the different metal species, which are confirmed by complementary quantum calculations.
A nonvolatile single ferro fet memory concept with disturbance free operation scheme (2001)

Abstract A novel AND-type ferroelectric field effect transistor memory concept for solid state mass storage applications is described. Disturbance problems caused by disturbance pulses between adjacent memory cells are prevented by device improvements and by choosing appropriate programming and read voltages. The memory array presented here uses global source lines each of which is connected to its own sense amplifier. Disturbance free and fully functional operation of the memory concept has been demonstrated by circuit simulations. The results of the simulations yield a data access time comparable to DRAMs.
ChemInform Abstract: Photochemical Reaction of ((η‐C5H5)W(CO3))Na with p‐Diiodobenzene in THF. X‐Ray Crystal Structure of the Resulting Carbene Complex. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Segmentation d'images et morphologie mathématique (1990)

Image segmentation by mathematical morphology is a mothodology based on the notions of watershed and homotopy modification. These tools are built starting from elementary morphological transformations which are presented in the first part of this thesis. These basic transformations are the morphological operations applied to grey-tone images and, in particular, the thinning and thickening operators together with the geodesic transformations. These tools lead to the design of more sophisticated transforms. Among them, the morphological gradient and its regularization,and the watershed transform. The latter transformation is introduced and itsrelationship with the geodesic operators and the homotopic thickenings is emphasized. Then various watershed algorithms are presented using the skeleton of a function and the representation of grey-tone images as a graph of arrows.<br />The second part is devoted to the use of these tools. A fair segmentation can be obtained when we use markers of the regions to be extracted to change the homotopy. These tools are also used for more complex segmentation. An image hierarchy is defined through the watershed transform.This hierarchy allows the segmentation of images where region marking is more difficult. Another example is given showing the difficulties as well as the advantages of this methodology.
Calcium‐, calcium/calmodulin‐, and calcium/phospholipid‐stimulated protein phosphorylation in the rat anterior pituitary (1992)

Calcium-dependent protein phosphorylation may be a critical step in the stimulated secretion of anterior pituitary hormones. We have noted the existence of a number of calcium-calcium/calmodulin-, and calcium/phospholipid-dependent phosphoproteins in the normal rat anterior pituitary. Cell extracts were prepared from anterior pituitary glands of male rats and phosphorylated with [gamma 32P]ATP in the presence or absence of calcium, calmodulin, and phosphatidylserine. The samples were electrophoresed on SDS-PAGE gels, autoradiographs prepared, and phosphate incorporation into specific proteins quantitated with microdensitometry. Calcium alone significantly stimulated the phosphorylation of proteins with molecular weights of 80.0-, 62.0-, 51.0-, 30.5-, and 25.0-kDa. The phosphorylation of 21.5-, 51.0-, and 80.0-kDa MW phosphoproteins was found to be phospholipid dependent. The phosphorylation of 62.0-, 51.0-, 33.0-, 30.5-, and 25.0-kDa MW phosphoproteins was found to be calcium/calmodulin kinase dependent. Calcium/calmodulin also inhibited phosphorylation of the 80.0-kDa phosphoprotein.