gebhart/patrepeval huggingface dataset:
Relationship between Gene Expression and Enhancement in Glioblastoma Multiforme: Exploratory DNA Microarray Analysis (2008)

The enhancement pattern divides GBM in two groups with differing prognoses. By comparing gene expression between IE and CE GBMs, it was possible to identify genes that may affect magnetic resonance imaging features of edema and enhancement, and genes whose expression levels are predictive of both improved and shortened survival.
Genetic Diversity among Clonal Lineages within<i>Escherichia coli</i>O157:H7 Stepwise Evolutionary Model (2007)

Escherichia coli O157:H7 variants were examined for trait mutations and by molecular subtyping to better define clonal complexes postulated on the O157:H7 evolution model. Strains of beta-glucuronidase-positive, sorbitol-negative O157:H7 isolated in United States and Japan were identical to A5 clonal strain and shared sequence type (ST)-65 by multilocus sequence typing (MLST); thus, they belong in A5. However, these strains exhibited pulsed-field gel electrophoresis (PFGE) profile differences that suggested genomic divergence between populations. Sorbitol-fermenting O157 (SFO157) strains from Finland, Scotland, and Germany were identical to A4 clonal strain and belong in A4. Some SFO157 strains, isolated years apart and from different countries, had identical PFGE profiles, suggesting a common origin. Despite similarities, some Finnish and Scottish and all of the German strains have ST-75 ("German clone"), whereas others have ST-76, a new variant ("Scottish clone"). MLST of strains in other clonal complexes also discriminated strains thought to be identical and showed that genetic differences will further distinguish clonal populations into subclones.
Combinatorial Approaches to Recognition of Chirality: Preparation and Use of Materials for the Separation of Enantiomers (2001)

Abstract For Abstract see ChemInform Abstract in Full Text.
Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: Insights from a patient-level pooled analysis of six randomized clinical trials (2014)

Liraglutide reduces SBP in patients with T2D, including those receiving concomitant antihypertensive medication.
SimTester (2012)

In software for embedded systems, the frequent use of interrupts for timing, sensing, and I/O processing can cause concurrency faults to occur due to interactions between applications, device drivers, and interrupt handlers. This type of fault is considered by many practitioners to be among the most difficult to detect, isolate, and correct, in part because it can be sensitive to execution interleavings and often occurs without leaving any observable incorrect output. As such, commonly used testing techniques that inspect program outputs to detect failures are often ineffective at detecting them. To test for these concurrency faults, test engineers need to be able to control interleavings so that they are deterministic. Furthermore, they also need to be able to observe faults as they occur instead of relying on observable incorrect outputs.
Haemodynamic collapse in a patient with acute inferior myocardial infarction and concomitant traumatic acute spinal cord injury (2013)

A 71-year-old man suddenly collapsed and went into cardiopulmonary arrest. The cardiopulmonary resuscitation attempt succeeded in restoration of spontaneous circulation. The initial 12-lead electrocardiogram showed inferior acute myocardial infarction (AMI). The patient was initially diagnosed as having cardiogenic shock associated with inferior AMI. In spite of early coronary revascularisation, bradycardia and hypotension were sustained. After termination of sedation and extubation, he was found to have a quadriplegia and diagnosed with a cervical spinal cord injury (SCI). Therefore, the patient was finally diagnosed with neurogenic shock caused by acute cervical SCI due to the traumatic injury preceded by loss of consciousness complicating inferior AMI. We should recognise that SCI has unique haemodynamic features that mimic those associated with inferior AMI, but requires very different treatment.
Observation of a controllable<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>π</mml:mi></mml:math>junction in a 3-terminal Josephson device (2002)

Recently Baselmans et al. [Nature, (London) $397,$ 43 (1999)] showed that the direction of the supercurrent in a superconductor/normal/superconductor Josephson junction can be reversed by applying, perpendicularly to the supercurrent, a sufficiently large control current between two normal reservoirs. The unusual behavior of their 4-terminal device (called a controllable $\ensuremath{\pi}$ junction) arises from the nonequilibrium electron energy distribution established in the normal wire between the two superconductors. We have observed a similar supercurrent reversal in a 3-terminal device, where the control current passes from a single normal reservoir into the two superconductors. We show theoretically that this behavior, although intuitively less obvious, arises from the same nonequilibrium physics present in the 4-terminal device. Moreover, we argue that the amplitude of the $\ensuremath{\pi}$-state critical current should be at least as large in the 3-terminal device as in a comparable 4-terminal device.
Circularly Polarized Cavities for Measurement of Tensor Permeabilities (1955)

First Page
Theoretical triangular quantum well model for AlGaN/GaN HEMT structure used as polar liquid sensor (2012)

A triangular quantum well model is introduced to investigate a doped AlGaN/GaN high electron mobility transistor (HEMT) structure as a sensor for polar liquids. We calculate the drain current of the transistor as a function of the dipole moment of the polar liquid. The results show good agreement with experimental measurements for different polar liquids. It is also found that the device has large linear sensitivity by detecting the change of drain current with dipole moment and therefore it can distinguish molecules with slightly different dipole moments. The device can be extended to sense biomolecules (such as proteins) with very large dipole moments.
Ionization and dissociation equilibriums in liquid sulfur dioxide. 13. The behavior of singly charged spherical and planar ions (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIonization and dissociation equilibriums in liquid sulfur dioxide. 13. The behavior of singly charged spherical and planar ionsNorman N. Lichtin, Bernard Wasserman, and John F. ReardonCite this: J. Phys. Chem. 1981, 85, 11, 1590–1595Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/j150611a026https://doi.org/10.1021/j150611a026research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Prolonged Histamine Deficiency in Histidine Decarboxylase Gene Knockout Mice Affects Leydig Cell Function (2006)

The present study focuses on histaminergic regulation of Leydig cell physiology, since limited information is available so far. To evaluate the dependency of Leydig cells on histamine (HA), we performed experiments using highly purified Leydig cells in culture, isolated from wild type (WT) and histidine decarboxylase (Hdc) gene knockout (HDC KO)-so HA-deprived-mice. HDC KO Leydig cells showed lower basal and human choriogonadotropin (hCG)-induced testosterone production compared to WT Leydig cells, presumably due to altered P450scc gene (Cyp11a1) expression levels. Moreover, in HDC KO cells, hCG did not increase basal expression levels of HA H1 and H2 receptor genes, while the hormone showed a significant inducing effect in WT cells. Based on these findings, we propose that prolonged HA deficiency in HDC KO mice affects various aspects of Leydig cell physiology, most importantly the response to hCG, providing definite evidence that HA plays a role as direct modulator of Leydig cell function and steroid synthesis in the testis. Also, the results presented herein constitute the first molecular evidence for the expression of HA H1 and H2 receptor subtypes in isolated Leydig cells.
The influence of substrate peptide length on human β‐tryptase specificity (2008)

Combinatorial chemistry approach was applied to design chromogenic substrates of human beta-tryptase. The most active substrate, Ala-Ala-Pro-Ile-Arg-Asn-Lys-ANB-NH(2), was selected from among over 9 million heptapeptides. The amide of 5-amino-2-nitrobenzoic acid (ANB-NH(2)) attached at the C-terminus served as a chromophore. In order to determine the optimal length of the tryptase substrate, a series of N-terminally truncated fragments of this substrate was synthesized. Pro-Ile-Arg-Asn-Lys-ANB-NH(2), with the determined value of the specificity constant (k(cat)/K(M)) above 9 x 10(6) M(-1) s(-1), appeared to be the most specific substrate of tryptase. This substrate was twice as active as the parent heptapeptide substrate. We postulate that the optimal size of the pentapeptide substrate for the interaction with human beta-tryptase is associated with the unique structure of this proteinase, comprising four almost identical monomer subunits arranged in a square flat ring with its substrate pockets faced inside, forming a tetramer with a central pore that can be penetrated by this short peptide.
Analysis of timing jitter in ring oscillators due to power supply noise (2003)

This paper presents a time-domain method for estimating the jitter in ring oscillators that is due to power supply noise. The method is used to analyze and compare the RMS cycle-to-cycle jitter of ring oscillators constructed from three possible delay elements: a CMOS digital inverter, a differential pair, and a current steering logic (CSL) inverter. Spice simulations verify the analysis method, and the results indicate that both the differential pair and CSL inverter provide superior supply noise immunity to the CMOS digital inverter.
Water requirements of relapsing fever tick larvae,<i>Ornithodoros turicata</i>(Acari: Argasidae), and the relative humidity of hatching eggs (1998)

Abstract The argasid tick, Ornithodoros turicata (Dugès), thrives in stable, warm, dry microhabitats within the nests of their hosts. Exposure of eggs to relatively dry and humid conditions altered the water balance profile of resultant newly-hatched larvae. Tick larvae that developed at 75% RH contained less body water and absorbed water vapor from lower relative humidities than larvae that developed at 93% RH. No differences in net water loss rate and dehydration tolerance were noted between the two groups. For the first time, this suggests that the pump threshold, the lowest relative humidity required for activation of water vapor uptake, can be modified.
Littoral assessment of mine burial signatures (LAMBS): buried landmine/background spectral-signature analyses (2004)

The objective of the Office of Naval Research (ONR) Rapid Overt Reconnaissance (ROR) program and the Airborne Littoral Reconnaissance Technologies (ALRT) project's LAMBS effort is to determine if electro-optical spectral discriminants exist that are useful for the detection of land mines in littoral regions. Statistically significant buried mine overburden and background signature data were collected over a wide spectral range (0.35 to 14 µm) to identify robust spectral features that might serve as discriminants for new airborne sensor concepts. LAMBS has expanded previously collected databases to littoral areas - primarily dry and wet sandy soils - where tidal, surf, and wind conditions can severely modify spectral signatures. At AeroSense 2003, we reported completion of three buried mine collections at an inland bay, Atlantic and Gulf of Mexico beach sites. We now report LAMBS spectral database analyses results using metrics which characterize the detection performance of general types of spectral detection algorithms. These metrics include mean contrast, spectral signal-to-clutter, covariance, information content, and spectral matched filter analyses. Detection performance of the buried land mines was analyzed with regard to burial age, background type, and environmental conditions. These analyses considered features observed due to particle size differences, surface roughness, surface moisture, and compositional differences.
Privacy Preserving Randomized Gossip Algorithms (2017)

In this work we present three different randomized gossip algorithms for solving the average consensus problem while at the same time protecting the information about the initial private values stored at the nodes. We give iteration complexity bounds for all methods, and perform extensive numerical experiments.
Consequences of the Expanding Global Distribution of Aedes albopictus for Dengue Virus Transmission (2010)

The dramatic global expansion of Aedes albopictus in the last three decades has increased public health concern because it is a potential vector of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral pathogen of humans, dengue virus (DENV). Ae. aegypti is considered the primary DENV vector and has repeatedly been incriminated as a driving force in dengue's worldwide emergence. What remains unresolved is the extent to which Ae. albopictus contributes to DENV transmission and whether an improved understanding of its vector status would enhance dengue surveillance and prevention. To assess the relative public health importance of Ae. albopictus for dengue, we carried out two complementary analyses. We reviewed its role in past dengue epidemics and compared its DENV vector competence with that of Ae. aegypti. Observations from "natural experiments" indicate that, despite seemingly favorable conditions, places where Ae. albopictus predominates over Ae. aegypti have never experienced a typical explosive dengue epidemic with severe cases of the disease. Results from a meta-analysis of experimental laboratory studies reveal that although Ae. albopictus is overall more susceptible to DENV midgut infection, rates of virus dissemination from the midgut to other tissues are significantly lower in Ae. albopictus than in Ae. aegypti. For both indices of vector competence, a few generations of mosquito colonization appear to result in a relative increase of Ae. albopictus susceptibility, which may have been a confounding factor in the literature. Our results lead to the conclusion that Ae. albopictus plays a relatively minor role compared to Ae. aegypti in DENV transmission, at least in part due to differences in host preferences and reduced vector competence. Recent examples of rapid arboviral adaptation to alternative mosquito vectors, however, call for cautious extrapolation of our conclusion. Vector status is a dynamic process that in the future could change in epidemiologically important ways.
Hippocampal mossy fiber sprouting and elevated trkB receptor expression following systemic administration of low dose domoic acid during neonatal development (2007)

We have previously reported that serial systemic injections of low-dose (subconvulsive) domoic acid (DOM) during early postnatal development produces changes in both behavior and hippocampal cytoarchitecture in aged rats (17 months) that are similar to those seen in existing animal models of temporal lobe epilepsy. Herein we report further hippocampal changes, consisting of mossy fiber sprouting and associated changes in the trkB receptor population in young adult (3 months) rats, and further, report that these changes show regional variation throughout the septo-temporal axis of the hippocampus. Groups of Sprague Dawley rat pups were injected daily from postnatal day 8-14 with either saline (n = 23) or 20 microg/kg DOM (n = 25), tested for key indicators of neonatal neurobehavioral development, and then left undisturbed until approximately 90 days of age, at which time brain tissue was removed, hippocampi were dissected, fixed and processed using either Timm's stain to visualize hippocampal mossy fiber sprouting (MFS) or trkB immunohistochemistry to visualize full length trkB receptors. Multiple sections from dorsal, mid, and ventral hippocampus were analyzed separately and all measures were conducted using image analysis software. The results indicate significant increases in MFS in the inner molecular layer in treated animals with corresponding changes in trkB receptor density. Further we identified significant increases in trkB receptor density in the hilus of the dentate gyrus and area CA3 and report increased mossy fiber terminal density in the stratum lucidum in treated rats. The magnitude of these changes differed between sections from dorsal, mid, and ventral hippocampus. We conclude that low dose neonatal DOM produces cytoarchitectural changes indicative of abnormal development and/or synaptic plasticity that are progressive with age and show regional variation within the hippocampal formation.
Thermal expansion of Cu(II)O nano‐ and micro‐particles and composites at cryogenic temperatures (2012)

Abstract A systematic study of the thermal expansion of copper oxide (CuO) nanoparticles and copper oxide‐based composites, prepared by a range of techniques, was performed at cryogenic temperatures in the effort to reproduce recently reported giant negative coefficient of thermal expansion (CTE) of CuO nanoparticles. Chemically synthesized CuO nanoparticles, nanoparticles formed by ball milling of CuO material, CuO nanoparticles with differing surface functionalization, particles subjected to post‐treatments such as electron irradiation, and embedded into various resins or compacted at high pressures were studied by dilatometry and X‐ray diffraction (XRD) at temperatures between 20 and 300 K. None of the samples exhibited large negative CTE in the examined temperature range.
The Stabilization of Methyl Radical (1954)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation I. L. Mador; The Stabilization of Methyl Radical. J. Chem. Phys. 1 September 1954; 22 (9): 1617. https://doi.org/10.1063/1.1740479 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search
Coded Modulation for High Spectral Efficiency Long-Haul Optical Transmission System (2013)

We review Trellis coded modulation and bit interleaved coded modulation (BICM) in optical communication systems. BICM with four dimensional mapping using single parity coding is discussed for high spectral efficiency transoceanic transmission systems.
Multisensor very lowbit rate speech coding using segment quantization (2008)

We present two approaches to noise robust very low bit rate speech coding using wideband MELP analysis/synthesis. Both methods exploit multiple acoustic and non-acoustic input sensors, using our previously-presented dynamic waveform fusion algorithm to simultaneously perform waveform fusion, noise suppression, and cross-channel noise cancellation. One coder uses a 600 bps scalable phonetic vocoder, with a phonetic speech recognizer followed by joint predictive vector quantization of the error in wideband MELP parameters. The second coder operates at 300 bps with fixed 80 ms segments, using novel variable-rate multistage matrix quantization techniques. Formal test results show that both coders achieve equivalent intelligibility to the 2.4 kbps NATO standard MELPe coder in harsh acoustic noise environments, at much lower bit rates, with only modest quality loss.
THEME 6. PLANNING AND EVALUATION OF VARIOUS SOLUTIONS FOR URBAN ROAD NETWORKS (1972)

This theme deals with the following forecast of urban journeys; planning of urban transport networks in the USA - present trends; planning and evaluation of various solutions for urban road networks; study of a new concept of street network in the town of Barcelona; motorways and traffic problems in towns. See also IRRD abstracts nos. 102102 and 207613. /TRRL/
Analgesic effect of 2-methylaminomethyl 2, 3-dihydrobenzofuran (EPS-4032) (1971)

2-Methylaminomethyl 2, 3-dihydrobenzofuran (EPS-4032) revealed relatively potent analgesic effect on various method in mice. Its effect was roughly equivalent to codein and as 5 times potent as aminopyrine. Morphine analgesia was apparently antagonized by levallorphan, while EPS-4032 analgesia was markedly potentiated by it, as well as aminopyrine. In the animals pretreated with reserpine or tetrabenazine, EPS-4032 and morphine failed to produced analgesic action. However, this antagonism was disappeared by administration of 1-DOPA after tetrabenazine. Analgesic effect of EPS-4030 was significantly intencified with pretreatment of nialamide and SKF-525A, but apparently reduced by pretreatment of phenobarbital. Also slight developement of tolerance was observed by repeated administration of EPS-4032 on mice.
The interactive presentation of 3D information obtained from reconstructed datasets and 3D placement of single histological sections with the 3D portable document format (2010)

Interpretation of the results of anatomical and embryological studies relies heavily on proper visualization of complex morphogenetic processes and patterns of gene expression in a three-dimensional (3D) context. However, reconstruction of complete 3D datasets is time consuming and often researchers study only a few sections. To help in understanding the resulting 2D data we developed a program (TRACTS) that places such arbitrary histological sections into a high-resolution 3D model of the developing heart. The program places sections correctly, robustly and as precisely as the best of the fits achieved by five morphology experts. Dissemination of 3D data is severely hampered by the 2D medium of print publication. Many insights gained from studying the 3D object are very hard to convey using 2D images and are consequently lost or cannot be verified independently. It is possible to embed 3D objects into a pdf document, which is a format widely used for the distribution of scientific papers. Using the freeware program Adobe Reader to interact with these 3D objects is reasonably straightforward; creating such objects is not. We have developed a protocol that describes, step by step, how 3D objects can be embedded into a pdf document. Both the use of TRACTS and the inclusion of 3D objects in pdf documents can help in the interpretation of 2D and 3D data, and will thus optimize communication on morphological issues in developmental biology.