gebhart/patrepeval huggingface dataset:
The main approaches for description of the topochemistry of macromolecular metal complexes (2002)

The topochemistry of the distribution of metal complexes on macromolecule ligands is studied on an example of macrocomplexes obtained by the interaction of transition metal compounds (MXn) with functional groups of the grafted layer (PE-gr-polyallylamine, PE-gr-polyacrylic acid, PE-gr-poly-4-vinylpyridine, etc.). Three main types of macrocomplexes are found out: I - isolated complexes (r̄ ≥ 15 Å); II - the aggregations of cluster types (complexes of paramagnetic metals unbounded chemically between each other) (r̄ ≤ 7 Å). III - clusters with a strong exchange interaction (exchange-bound clusters caused by chemical bonds of complexes similar to polynuclear complexes). The ratio and distances between complexes of differen types as well as their possible role in catalytic processes are estimated and discussed.
Comparaison of reference tissue model versus two compartement model with input function for [18F]Fallypride modelling. A combined microPET-Beta microprobe study in rat. (2009)

peer reviewed
Crom: Faster web browsing using speculative execution (2010)

Early web content was expressed statically, making it amenable to straightforward prefetching to reduce user-perceived network delay. In contrast, today's rich web applications often hide content behind JavaScript event handlers, confounding static prefetching techniques. Sophisticated applications use custom code to prefetch data and do other anticipatory processing, but these custom solutions are costly to develop and application-specific.This paper introduces Crom, a generic JavaScript speculation engine that greatly simplifies the task of writing low-latency, rich web applications. Crom takes preexisting, non-speculative event handlers and creates speculative versions, running them in a cloned browser context. If the user generates a speculated-upon event, Crom commits the precomputed result to the real browser context. Since Crom is written in JavaScript, it runs on unmodified client browsers. Using experiments with speculative versions of real applications, we show that pre-commit speculation overhead easily fits within user think time. We also show that speculatively fetching page data and precomputing its layout can make subsequent page loads an order of magnitude faster.
Genome sequence of the deep-sea γ-proteobacterium <i>Idiomarina loihiensis</i> reveals amino acid fermentation as a source of carbon and energy (2004)

We report the complete genome sequence of the deep-sea gamma-proteobacterium, Idiomarina loihiensis, isolated recently from a hydrothermal vent at 1,300-m depth on the Loihi submarine volcano, Hawaii. The I. loihiensis genome comprises a single chromosome of 2,839,318 base pairs, encoding 2,640 proteins, four rRNA operons, and 56 tRNA genes. A comparison of I. loihiensis to the genomes of other gamma-proteobacteria reveals abundance of amino acid transport and degradation enzymes, but a loss of sugar transport systems and certain enzymes of sugar metabolism. This finding suggests that I. loihiensis relies primarily on amino acid catabolism, rather than on sugar fermentation, for carbon and energy. Enzymes for biosynthesis of purines, pyrimidines, the majority of amino acids, and coenzymes are encoded in the genome, but biosynthetic pathways for Leu, Ile, Val, Thr, and Met are incomplete. Auxotrophy for Val and Thr was confirmed by in vivo experiments. The I. loihiensis genome contains a cluster of 32 genes encoding enzymes for exopolysaccharide and capsular polysaccharide synthesis. It also encodes diverse peptidases, a variety of peptide and amino acid uptake systems, and versatile signal transduction machinery. We propose that the source of amino acids for I. loihiensis growth are the proteinaceous particles present in the deep sea hydrothermal vent waters. I. loihiensis would colonize these particles by using the secreted exopolysaccharide, digest these proteins, and metabolize the resulting peptides and amino acids. In summary, the I. loihiensis genome reveals an integrated mechanism of metabolic adaptation to the constantly changing deep-sea hydrothermal ecosystem.
Abstract 3645: A non-ATP competitive IKKβ inhibitor for cancer therapy (2015)

Abstract Kinases are promising targets in cancer drug discovery. IKKβ is an important kinase in the canonical NF-κB pathway, which promotes survival of cancer cells and is constitutively active in number of cancers including pancreatic cancer. Inflammatory stimulus such as tumor necrosis factor-α (TNFα) is known to activate the canonical IKKβ-NF-κB pathway. Upon TNFα stimulation, serine residues 177 and 181 in the activation loop of IKKβ undergo phosphorylation resulting in activated IKKβ. Immunohistochemistry (IHC) studies showed the presence of the proinflammatory cytokine TNFα in ∼50% of surgically resected tumor specimens but in only ∼10% of corresponding normal tissues. Consistently, IHC studies by us with patient samples obtained from the UNMC rapid autopsy pancreatic cancer program showed elevated levels of phosphorylated S181 IKKβ in the tumor and liver metastases samples when compared to the stroma and ductal cells for normal pancreas. Several small molecule IKKβ inhibitors were developed by pharmaceutical industry to treat chronic inflammatory diseases. Despite complete preclinical characterization of many candidates, to date none of them has been approved by the FDA for clinical use. Nearly all the small molecule IKKβ inhibitors reported are ATP competitive. These inhibitors completely block IKKβ mediated NF-κB activity as a result chronic administration in mice leads to granulocytosis and increased susceptibility to infection-mediated death. Here we report the discovery a non-ATP competitive IKKβ inhibitor that allows transient activation but blocks the sustained activation of IKKβ mediated NF-κB activity. We present a model that has a novel-binding site, which is accessible upon activation of IKKβ and explains the observed experimental results. Our IKKβ inhibitor does not share the toxicity profile of the ATP competitive IKKβ inhibitors. In an orthotopic pancreatic tumor model mice treated with our inhibitor showed reduced tumor growth and metastasis compared to vehicle controls. We also showed that in a mantle cell lymphoma model the median survival of mice treated with our inhibitor nearly doubled when compared vehicle treated mice. Our results suggest that non-ATP competitive IKKβ inhibitors are viable lead candidates for cancer therapy. Citation Format: Sandeep Rana, Elizabeth Blowers, Amarnath Natarajan. A non-ATP competitive IKKβ inhibitor for cancer therapy. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3645. doi:10.1158/1538-7445.AM2015-3645
Separating colorred signals distorted by convolutive channels using diagonal constrained decorrelation (2002)

We consider the problem of separating colorred signals mixed by unknown convolutive channels. We introduce a variation of a previous approach of separating signals via decorrelation. This variation minimizes the mutual correlation among the output signals of a decorrelation matrix subject to a diagonal constraint. The diagonal constraint ensures a better quality of separation. The diagonal constraint is shown to be essential when the number of original signals is less than the number of distorted signals
Site-transfer electronic conductivity. The hopping or polaron (direct-current) mechanism from dielectric relaxation studies on intervalence mixtures and charge-transfer adducts (1981)

A basically phenomenologicalk relationship between the direct-current (d.c.) conductivity and the characteristic dielectric relaxation frequency is derived for solids in which site-to-site transfer of electrons is the mechanism for both the conductivity and the dielectric polarisation. It is shown to hold approximately for the mixed-valence salt K3(MnO4)2(for which the experimental data are reported), and also for the perylene-chloranil adduct, for complexes of proteins with methylglyoxal and for further biological molecules. The relevance to charge-transfer spectra is indicated. The d.c. conductivities of KMnO4+ K2MnO4 mixtures are reported, confirming the intervalence site-transfer mechanism to be dominant in K3(MnO4)2.
New strontium-based bioactive glasses: physicochemical reactivity and delivering capability of biologically active dissolution products (2009)

The development of bone tissue regeneration calls for biomaterials able to release biologically active substances in a controlled manner after implantation. In this context, strontium-doped bioactive glasses are of major interest; their key property relies on the increased kinetics of surface reactions, along with the release of critical concentrations of ionic dissolution products capable of stimulating cellular responses. In this paper, we report a complete evaluation of the in vitro reactivity of new SiO2–CaO–SrO and SiO2–CaO–P2O5–SrO bioactive glasses. In contact with simulated acellular physiological fluids, these materials induce the formation of a calcium phosphate surface layer that closely resembles to the biological apatite present in bones. The two most commonly used materials shapes for clinical applications – glass particles and glass bulk – were studied and provide us with concordant results. Compared to strontium-free materials, the dissolution of SiO2–CaO–SrO and SiO2–CaO–P2O5–SrO glasses is reduced. However, the surface layer is more quickly transformed into a bone-like apatite phase, according to the kinetics of evolution of the Ca/P atomic ratio. Evidences of the presence of Sr at the glass/biological fluids interface were obtained, along with the demonstration that this element is released in physiological concentrations into the biological environment. Knowing the well-recognized beneficial effects of strontium on cell activity and bone remodeling, this crucial result gives high hopes for the development of innovative applications based on Sr-doped glasses in the treatment of osteoporosis and tissue engineering.
ChemInform Abstract: Synthesis of Enantiopure 3‐Substituted Pyrroline N‐Oxides by Highly Regioselective Oxidation of the Parent Hydroxylamines: A Mechanistic Rationale. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Effect of Nb on High Temperature Properties of Austenitic Steels. (1959)

This report concerned the effect of Nb and C on mechanical properties such as creeprupture strength; tensile strength, impact value and deformation resistance at high temperature, aging hardness and microstructure of austenitic stainless steels. Specimens used in the experiments were 18 Cr-12 Ni austenitic stainless stees. The C content of the steels were of three kinds (0.03, 0.06, 0.12%).The Nb content were n times as much as C for each C content (in this case n=0, 5, 8, 10, 12, 15). In these steels, Nb C and Cr23C6 precipitated during aging at 600, 650, 700 and 750°C. Precipitates were concentrated by electrolyzing specimens in ethyl alcohol containing 10% of HCl, and examined by X-ray diffraction method. Cr23C6 precipitated mainey on grain boundary but it had no effect on aging hardness.Creep rupture strength increased with Nb content but it was almost invariable when Nb content exceeded about 11 times as much as C content. High-temperature tensile. strength was almost invariable with Nb content. There was no correlation between the effect of Nb on creep rupture strength and that on high-temperature tensile strength.High-temperature deformation-resistance depended only upon the amount of Nb dissolved in matrix.
Digital cross-connect systems: network-based vehicles for private T1 resource management (2003)

Operating companies are gradually considering network-based equipment as bases for T1 resource management. This emerging role for digital cross-connect systems (DCSs), wherein the operating company uses that equipment as vehicles for the operation, administration, and maintenance (OA&M) of private T1 networks, is described. It is noted that DCSs have only recently found acceptance as LEC (local exchange carrier) vehicles for intraLATA T1 resource management of private networks. These cross-connects are today deployed as small, dedicated units serving a single network, as partitioned fabrics providing a virtual service to several private networks, or as functional units within T1 multiplexers situated in central offices. The latter application can ultimately bring end users high functionality at reduced cost, while also providing direct gateways into public network services. This multiplexer approach points the way for an evolving seamless premises-to-network service, one in which a single protocol would interface a network management platform that directs OA&M functions to element managers that then interoperate with disparate communication equipment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
5.1: Active Matrix Organic Light Emitting Diode Panel using Organic Thin‐Film Transistors (2004)

Abstract By using organic thin‐film transistors with pentacene as the active organic layer, active matrix organic light emitting diode panel has been developed. The number of pixels in the panel is 8 × 8, and each pixel is driven by switching and driving transistors. We confirmed 16 gray scales representation by means of an analog driving method.
Design and performance evaluation of small, two- and four-stage depressed collectors for a 4.8 to 9.6 GHz high-performance traveling wave tube (1976)

A program to improve the efficiency of traveling wave tubes (TWT's) for use in electronic countermeasure (ECM) systems by applying multistage depressed collector (MDC) and spent beam refocusing techniques is studied. Three dimensional electron trajectories are computed through-out the slow wave structure of the TWT, the spent beam refocuser, and the depressed collector. Both TWT and MDC performances are analytically evaluated.
The Absorption Spectra and Decay Kinetics of the Metastable States of Chlorophyll A and B<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Absorption Spectra and Decay Kinetics of the Metastable States of Chlorophyll A and B1Henry Linschitz and Kyosti SarkanenCite this: J. Am. Chem. Soc. 1958, 80, 18, 4826–4832Publication Date (Print):September 1, 1958Publication History Published online1 May 2002Published inissue 1 September 1958https://pubs.acs.org/doi/10.1021/ja01551a018https://doi.org/10.1021/ja01551a018research-articleACS PublicationsRequest reuse permissionsArticle Views723Altmetric-Citations185LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hybridization Analysis of Histone Messenger RNA: Association with Polyribosomes During the Cell Cycle (1975)

Hybridization of cell cycle stage-specific polyribosomal RNA's to histone complementary DNA indicates that histone messenger RNA sequences are present on polyribosomes of Hela S3 cells only during the period of DNA replication.
[Immunohistochemical studies of bronchial carcinoma using monoclonal antibody A63-C/A3]. (1991)

An immunohistological study was undertaken, using paraffin sections of 22 cases of lung carcinoma and a number of reference tissue samples, to clear up the reactivity of A63-C/A63 monoclonal antibody (IgM) which was capable of identifying a carcinoma-associated carbohydrate antigen. Following neuraminidase pretreatment of those sections, positive response to the above antigen was produced by more than 90% of all bronchial carcinoma samples, notwithstanding the histological type involved (squamous-cell carcinoma or adenocarcinoma). Columnar epithelium of the bronchi, not involved in the neoplastic process gave a positive immunoreaction with the antibody A63-C/A3 in 64% of the cases.
New Clues about the Evolutionary History of Metabolic Losses in Bacterial Endosymbionts, Provided by the Genome of Buchnera aphidicola from the Aphid Cinara tujafilina (2011)

The symbiotic association between aphids (Homoptera) and Buchnera aphidicola (Gammaproteobacteria) started about 100 to 200 million years ago. As a consequence of this relationship, the bacterial genome has undergone a prominent size reduction. The downsize genome process starts when the bacterium enters the host and will probably end with its extinction and replacement by another healthier bacterium or with the establishment of metabolic complementation between two or more bacteria. Nowadays, several complete genomes of Buchnera aphidicola from four different aphid species (Acyrthosiphon pisum, Schizaphis graminum, Baizongia pistacea, and Cinara cedri) have been fully sequenced. C. cedri belongs to the subfamily Lachninae and harbors two coprimary bacteria that fulfill the metabolic needs of the whole consortium: B. aphidicola with the smallest genome reported so far and "Candidatus Serratia symbiotica." In addition, Cinara tujafilina, another member of the subfamily Lachninae, closely related to C. cedri, also harbors "Ca. Serratia symbiotica" but with a different phylogenetic status than the one from C. cedri. In this study, we present the complete genome sequence of B. aphidicola from C. tujafilina and the phylogenetic analysis and comparative genomics with the other Buchnera genomes. Furthermore, the gene repertoire of the last common ancestor has been inferred, and the evolutionary history of the metabolic losses that occurred in the different lineages has been analyzed. Although stochastic gene loss plays a role in the genome reduction process, it is also clear that metabolism, as a functional constraint, is also a powerful evolutionary force in insect endosymbionts.
Imaging Features of Carcinoid Tumors of the Gastrointestinal Tract (2013)

Gastrointestinal carcinoids are a biologically heterogeneous group of tumors, with variable clinical presentation and biologic behavior. Imaging can play an important role in multidisciplinary identification and management of this disease.
High-field cyclotron resonance and impurity transition in<i>n</i>-type and<i>p</i>-type 3C-SiC at magnetic fields up to 175 T (1993)

Magnetotransmission experiments have been carried out on 3C-SiC thin films grown on Si(100) substrates, using the combination of pulsed high magnetic fields up to 175 T generated by the single-turn coil technique and pulsed far-infrared radiations from a ${\mathrm{H}}_{2}$O (${\mathrm{D}}_{2}$O) laser at photon energies up to 73.2 meV. In n-type 3C-SiC, two cyclotron-resonance (CR) peaks have been observed for B\ensuremath{\parallel}k\ensuremath{\parallel}〈100〉 over a wide range of photon energy 10.4--53.8 meV, corresponding to the light- and heavy-mass valleys at the X points, i.e., ${\mathit{m}}_{\mathit{t}}^{\mathrm{*}}$=(0.25\ifmmode\pm\else\textpm\fi{}0.01)${\mathit{m}}_{0}$ and (${\mathit{m}}_{\mathit{t}}^{\mathrm{*}}$${\mathit{m}}_{\mathit{l}}^{\mathrm{*}}$${)}^{1/2}$=(0.41\ifmmode\pm\else\textpm\fi{}0.01)${\mathit{m}}_{0}$. These values are in agreement with those of Kaplan et al. obtained from CR at low fields. This leads to the conclusion that the conduction band in 3C-SiC is very parabolic up to 53.8 meV, and that unlike GaP the effect of camel's-back structure is unobservable. A number of impurity transitions were observed at temperatures below 100 K with photon energies ranging from 34.4 to 73.2 meV. It was found that the observed lines originate from three different donor states which have different binding energies, ${\mathit{E}}_{\mathit{d}}$=19, 35, and 53 meV. The observation of hole CR was also made in p-type 3C-SiC. A broad but prominent peak was observed with an effective mass of 0.45${\mathit{m}}_{0}$, at temperatures around 210 K and at a wavelength of 119 \ensuremath{\mu}m.
Adaptive critic designs for host-based intrusion detection (2003)

We explore adaptive critic designs for host-based intrusion detection because of their utilization of reinforcement learning, which allows learning exploits that are difficult to pinpoint in sensor data. Results on Solaris basic security module audit data demonstrate an ability to learn to distinguish between clean and exploit data.
A new way to evaluate steel sheet surfaces (2009)

This paper introduces a new assessment technique to monitor the quality of coated steel sheet surfaces, mainly used in the construction industry, e.g. as cladding for commercial buildings, external surface composite panels or even domestic applications, so clearly the visual appearance is critical. Normally, these types of steel sheets are coil coated onto steel strips. After curing the coating is soft, when it has cooled to approximated 60 C it can be embossed with a pattern by application of pressure by a roller with the appropriately pattered surface. After embossing and further cooling the coated strip can be coiled and stored. However during the storing process the weight of the coil (of the order of several tonnes), can damage the soft surface by creating visible pressure marks. Sometimes the surface will relax back to the original embossed shape some time after the pressure has been relieved or with the help of heat treatment. On occasion however the surface does not recover and a visual defect remains, which leads to customer rejection.\n\nIn this paper, a new way to characterize coated surface of steel sheets, which combines wavelet filtering [1] with decomposed numerical analysis techniques [2] is presented. The wavelet filtering is based on complex wavelet, and it has very good metrological characteristics in the scale domain and provides shift-invariance and directions sensitive properties. In this research, this wavelet model is used to extract the information of structured texture of coated steel surfaces within the original emboss. The decomposed numerical description is used to qualify the variation phenomena of surface texture during storage and transportation. The results can be feedback to steel industry to significantly improve their coating techniques, storage and transportation.