gebhart/patrepeval huggingface dataset:
An Open-Label, Unit Dose-Finding Study Evaluating the Safety and Platelet Response of a Novel Thrombopoietic Protein (AMG531) in Thrombocytopenic Adult Patients (Pts) with Immune Thrombocytopenic Purpura (ITP). (2004)

Abstract This study is an open-label phase 1 study of a novel thrombopoietic agent, AMG531. AMG531 acts through activation of the receptor Mpl to stimulate the growth and maturation of megakaryocytes ultimately resulting in blood platelets (plts). Thrombocytopenic adult pts with ITP were enrolled into sequential cohorts of AMG531 at the assigned unit doses of 30, 100, 300, or 500 μg. There were to be 4 pts per cohort with additional pts in a confirmatory cohort at the selected dose (300 μg). Major eligibility criteria were: diagnosis of ITP as defined by the ASH Guidelines 3 months prior to study entry, baseline platelet (plt) count (ct) <30x109/L (<50x109/L if on corticosteroids), age >18 years and no history of thrombosis. Patients were to receive 2 administrations of AMG531 on study day 1 and 15 (or day 22 if plt cts were >50x109/L on day 15). Follow-up continued for 8 weeks after the last dose for safety. The primary objective was safety and the secondary objectives were related to plt response defined as doubling of baseline plt ct and ≥50x109/L and <450x109/L. Sixteen pts were enrolled into 5 cohorts with the following demographics: 10/16 (63%) females, median age 50 years (range 20–84), 13/16 having had splenectomy (splx). Fourteen of the 16 pts received both administrations of AMG531, and 4 pts received the second dose on day 22. No safety issues or concerns were identified. Headache was the most frequently reported adverse event (AE) in 6/16 (38%) of pts. There were 3 serious AEs reported to be related to AMG531, headache and a transient LDH increase in one pt and thrombocytopenia reported after completing AMG531 in another. Hemoglobin, WBC, blood chemistry and coagulation variables remained stable over the study period and no clinically significant on-study changes were identified. No anti-AMG531 or anti-TPO antibodies were detected. Platelet responses were observed in some pts either the first or second administration in all dose groups. Evaluation of the responses after conversion of the unit (μg) dose to μg/kg demonstrated that in pts that received dose-equivalents of >1 μg/kg, 8/12 (67%) pts achieved the plt response criterion with either the first or the second administration of AMG531. Of these pts with plt responses 6/8 (75%) had previously had a splx. Plt responses were not related to splx status or baseline plt cts. These data suggest that by-weight dosing is appropriate in this pt population and support the need for more frequent dosing. In summary, AMG531 was well tolerated at all doses tested and was capable of increasing plt cts in 67% of pts with ITP when doses equivalent to >1 μg/kg were administered. Future studies will explore the effects of long-term, weekly by-weight dosing with AMG531 to evaluate the durability of this response. These data suggest that stimulation of platelet production with AMG531 in pts with ITP may provide a new treatment option for ITP regardless of splx status.
Growth of <i>Listeria monocytogenes</i> at different pH values in uncultured whey or whey cultured with <i>Penicillium camemberti</i> (1988)

Wheys from making Camembert cheese were either uncultured or cultured with Penicillium camemberti, adjusted to pH 5.0, 5.2, 5.4, 5.6, 6.2, and 6.8, and filter sterilized. Whey samples were inoculated to contain 100 to 500 Listeria monocytogenes (strains Scott A, V7, CA, or OH) cfu/mL and incubated at 6 degrees C. Counts of L. monocytogenes were obtained by surface plating appropriate dilutions on Tryptose Agar. Listeria monocytogenes failed to grow at or below pH 5.4; except for strains Scott A and OH which grew in cultured whey at pH 5.4 and attained populations of 7.8 x 10(3) and 5.4 x 10(4) cfu/mL, respectively, after 35 d of storage. In uncultured whey at pH 5.6, 6.2, and 6.8, populations of L. monocytogenes increased from 7.20 to 7.81, 7.51 to 8.23, and 7.48 to 8.08 log10 cfu/mL, respectively, after 35 d of storage at 6 degrees C. In cultured whey at pH 5.6, 6.2, and 6.8, numbers of L. monocytogenes increased from 7.53 to 8.13, 7.82 to 8.55, and 7.95 to 8.80 log10 cfu/mL, respectively, after 35 d of storage. Generation times for L. monocytogenes at 6 degrees C in uncultured whey at pH 5.6, 6.2, and 6.8 ranged between 25.3 and 31.6 h, 14.8 and 21.1 h, and 14.0 and 19.4 h, respectively, depending on the Listeria strain. In contrast, generation times were significantly (p less than 0.05) shorter in cultured whey and ranged between 16.6 and 27.4 h, 10.3 and 16.6 h, and 17.4 and 16.3 h at pH values of 5.6, 6.2, and 6.8, respectively.
Homoclinic splitting, II. A possible counterexample to a claim by Rudnev and Wiggins on Physica D (1998)

Results in the mentioned paper do not seem valid.
A method and installation for removing acidic impurities, topping, and drying of gases before their transport and refining (1980)

A method is patented of purification of acidic impurities, topping, and drying natural or casing-head gas. The acidic impurities--H2S and CO2--are separated by washing with an aqueous solution of SO2. The elementary sulfur thus formed is removed by filtration and partly used for producing SO2 by combustion in a special furnace. The gas is then treated with a hydrocarbon absorbent, separating the propane and other light condensable hydrocarbons. The saturated absorbent is washed with an aqueous solution of alkali to remove the acidic impurities it has entrapped, and the condensate is distilled off. The gas purified of acidic impurities and topped undergoes drying by glycol or molecular sieves. The flow-line scheme of the process is given and explained.
The metabolism of androgens in male pattern alopecia: a review (1981)

Synopsis The studies carried out on the metabolism of testosterone and other circulating androgens in human scalp skin and hair follicles have been reviewed with the aim of understanding the role of these androgens in male pattern alopecia (baldness).
A Facile One-pot Synthesis of Sulfides from Alkyl Halides and Alcohols Using Tetramethylthiourea (1985)

Abstract Sulfides can be readily prepared under mild conditions by a reaction of tetramethylthiourea with alkyl halides and alcohols in the presence of sodium hydride in satisfactory yields. The scope and limitation of this method are also presented.
Bioactive substrates for human retinal pigment epithelial cell growth from elastin‐like recombinamers (2013)

The aim of this study was to investigate the use of bioactive RGD-containing elastin-like recombinamers (ELR-RGDs) as a substrate that can maintain human retinal pigment epithelial cell (hRPE) phenotype and growth pattern. Results obtained are compared with previously published behavior of ARPE19 cells. The extension of these results to hRPE is required because ARPE19 cells cannot be used clinically to treat age-related macular degeneration. hRPE cells were isolated, cultured, seeded, and grown on surface of glass, treated polystyrene (TCP), and solvent-cast ELR-RGD and ELR-IK film with no specific sequence. Cells were analyzed to study cell adhesion, proliferation, morphology, and RPE65 protein expression by staining with diamidino-2-phenylindole, Rhodamine-Phalloidin, and anti-RPE65 antibody at 12, 24, 72, 120, 168, and 360 h. hRPE cells always grew better on ELR-RGD than on glass and ELR-IK but not on TCP. The kinetic hRPE growth curves confirmed that growth differences started to appear at 24 h for these surfaces in ascending order of cell growths, namely glass, ELR-IK, ELR-RGD, and TCP. There was a clear difference at 360 h. ELR-RGD maintained hRPE cells stable morphology and RPE65 protein expression. ELR-RGD seems to be a good substrate for growing hRPE cells with stable morphology and RPE65 protein expression. As such, this work confirms our hypothesis regarding ELR-RGD substrates viability, which can be used as a Bruch's membrane prosthesis for further studies in animals. However, these results must subsequently be extrapolated to use of hRPE cells in animals to evaluate them as a transplantation vehicle in human.
NAT Behavioral Requirements for ICMP protocol (2006)

This document identifies the behavioral properties required of the
Network Address Translator devices (NATs) in conjunction with the ICMP
protocol. The objective of this memo is to make NAT devices more
predictable and compatible with diverse application protocols that
traverse the devices. Companion documents provide behavioral
recommendations specific to TCP and UDP.
Proinflammatory Cytokines and Sickness Behavior in Rheumatic Diseases (2008)

This review describes mechanisms of immune-to-brain signaling that may contribute to disease-related changes in mood, affect and behavior in chronic inflammatory rheumatic diseases. The central nervous system (CNS) modulates immune function by signaling target cells of the immune system through autonomic and neuroendocrine pathways. These immune cells relay information back to autonomic, limbic and cortical areas of the CNS to affect neural activity and consequently modify behavior, hormone release and autonomic function. In this manner, immune cells function as a sense organ, informing the CNS of peripheral events relating to infection and injury. Equally important, homeostatic mechanisms are needed at all levels to turn off the immune response when the pathogen and injurious condition are eliminated and the repair process is completed. In individuals with chronic inflammatory diseases, such as rheumatoid arthritis (RA), there is a failure of the homeostatic regulation leading to long-term immune activation that has serious health consequences. Rheumatic disorders constitute a challenge to major psychological adaptation resources leading to higher rates of psychological disorders compared with the general population. Thus the relationship between disease pathology and psychological well being is complex.
Renal tubule Na,K-ATPase polarity in different animal models of polycystic kidney disease. (1995)

Apical mislocation of the ubiquitous transport enzyme Na,K-ATPase has been implicated as a feature of cyst development in in vitro studies of human polycystic kidney disease (PKD) epithelia. We undertook an immunohistochemical study of murine glucocorticoid-induced PKD, the pcy mouse, the cpk mouse, and the diphenylthiazole (DPT)-induced rat models of PKD to determine if this feature was common to these models of cyst development. Distribution of Na,K-ATPase was determined with a polyclonal anti-Na,K-ATPase antibody and a nickel-silver-enhanced peroxidase color development system. Results were documented objectively with densitometric techniques. Control animals appropriate to the age, strain, and species of the experimental groups demonstrated the expected polar distribution of Na,K-ATPase to the basolateral surface. This distribution was more marked in mature animals. Tubular dilatation and cystic change, however, were associated with increased apical Na,K-ATPase in all models. The murine models demonstrated decreased basolateral staining for Na,K-ATPase compared with controls, although this was not a feature of the DPT rat model. Abnormal location of Na,K-ATPase is a shared feature of a variety of animal models and human PKD. This may contribute to abnormal fluid and electrolyte flux favoring cyst formation or may represent expression of a less differentiated renal tubule epithelial phenotype.
Alignment of YBa <sub>2</sub> Cu <sub>3</sub> O <sub> 7‐ <i>x</i> </sub> and Ag─YBa <sub>2</sub> Cu <sub>3</sub> O <sub> 7‐ <i>x</i> </sub> Composites at ∼930°C by Eutectic Formation (1991)

The present work describes a new technique to synthesize aligned YBa 2 Cu 3 O 7‐ x and Ag─YBa 2 Cu 3 O 7‐ x superconducting composites from Ba‐ and Cu‐deficient compositions (relative to YBa 2 Cu 3 O 7‐ x ) plus BaCuO 2 . For YBa 2 Cu 3 O 7‐ x , high transition temperature midpoint T c (91 K), temperature of zero resistivity T 0 (90 K), and critical current density J c (>3000 A°Cm −2 at 77 K) were achieved by using this technique. This procedure provides the potential for using a reliable and reproducible densification and alignment technique alternative to partial or full melting. The composite is highly aligned, with an average grain size of ∼1 to 2 mm and domains of width greater than 5 mm. The initial phase assemblage consists of YBa 2 Cu 3 O 7‐ x (123) as the major phase plus YBa 2 CuO 5 (211) CuO as minor phases. The BaCuO 2 is added to the Ba‐ and Cu‐deficient starting composition in order to assist in the formation of a CuO‐rich liquid as well as to compensate for the Ba and Cu deficiences in 123. Since the liquid forms at ∼900°C and is compatible with 123, it can be used to facilitate alignment of 123 at ∼930°C. The addition of Ag to the system results in eutectic formation with the (solidified) liquid, substantial filling of the pores during sintering, and improved alignment.
Characterization of Solid Counterfeit Drug Samples by Desorption Electrospray Ionization and Direct‐analysis‐in‐real‐time Coupled to Time‐of‐flight Mass Spectrometry (2006)

Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown).
Effect of oxyfuel burner ratio changes on energy efficiency in electric arc furnace at Co-Steel Lasco (2001)

Trials were conducted on Co-Steel Lasco's electric arc furnace (EAF) to evaluate the effect of oxyfuel burner ratio changes on furnace energy efficiency and productivity. Carefully controlled trials with the collection of numerous process and sample data over 331 heats provided statistically significant results. The oxygen available for post-combustion in the furnace was increased by 19%. As the burners were operating at their maximum oxygen constraint, this was achieved by decreasing the natural gas consumption by 43%. Results of this study indicate that decreases in terms of specific electrical energy consumption (4·0%), power on time (5·0%), and tap to tap time (4·5%) were realised. Slag chemistry, electrode consumption, and yield were not affected. Measurement data support the finding that more heat was transferred into the steel with the post-combustion burners: a flat bath was achieved earlier; high bath temperatures were reached more quickly; power on time was reduced, leading to reduced electrical energy consumption. Analysis suggests that furnace thermal energy losses were reduced by less air inleakage, less incomplete methane combustion, and earlier achievement of foamy slag conditions.
Gas sensor for constituents of air|with semiconducting organic polymer enabling determination of composition of gas mixture or identification of pure, unknown sample (1997)

Analysing a gas sample comprises exposing at least one gas sensor to the sample. An alternating electric signal is applied to the sensor and the frequency of the signal is varied. An impedance characteristic of the sensor as a function of frequency is detected or calculated and compared to impedance characteristics obtained by exposing the sensor to gases or gas mixtures of known composition.Also claimed is an apparatus for gas sample analysis.USE - Used for analysing a gas sample.ADVANTAGE - By applying an alternating signal to a sensor with a semiconducting organic polymer the system may be used to determine the composition of a mixture of gases, or the identity of a pure but unknown gas sample, or if the gas sample is pure or to differentiate between samples of different, but unknown composition.
Investigations on Lignin and Lignification. XIII. Electrophoresis of Native and Enzymatically Liberated Lignins<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigations on Lignin and Lignification. XIII. Electrophoresis of Native and Enzymatically Liberated Lignins1W. J. Schubert, A. Passannante, George de Stevens, M. Bier, and F. F. NordCite this: J. Am. Chem. Soc. 1953, 75, 8, 1869–1873Publication Date (Print):April 1, 1953Publication History Published online1 May 2002Published inissue 1 April 1953https://pubs.acs.org/doi/10.1021/ja01104a027https://doi.org/10.1021/ja01104a027research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Negative thermal expansion and low-frequency modes in cyanide-bridged framework materials (2005)

We analyze the intrinsic geometric flexibility of framework structures incorporating linear metal--cyanide--metal $(\mathrm{M}\text{--}\mathrm{CN}\text{--}{\mathrm{M}}^{\ensuremath{'}})$ linkages using a reciprocal-space dynamical matrix approach. We find that this structural motif is capable of imparting a significant negative thermal expansion (NTE) effect upon such materials. In particular, we show that the topologies of a number of simple cyanide-containing framework materials support a very large number of low-energy rigid-unit phonon modes, all of which give rise to NTE behavior. We support our analysis by presenting experimental verification of this behavior in the family of compounds ${\mathrm{Zn}}_{x}{\mathrm{Cd}}_{1\ensuremath{-}x}{(\mathrm{CN})}_{2}$, which we show to exhibit a NTE effect over the temperature range $25--375\phantom{\rule{0.3em}{0ex}}\mathrm{K}$ more than double that of materials such as $\mathrm{Zr}{\mathrm{W}}_{2}{\mathrm{O}}_{8}$.
Study on LLDPE molecular structure characterization by preparative and analytical cross-fractionation (2010)

Abstract Two grades of LLDPE were analysed by a number of methods for fractionation and molecular structure determination (molecular weight, branching density). Methods used were: preparative fractionation according to comonomer content (TREF) and molecular weight (solvent - non solvent), CRYSTAF, SEC, SEC-FTIR and NMR. We explore different ways of combining and processing data to obtain two and three dimensional results. Methods to correct for chain end effects in and construct bivariate distributions from preparative TREF + SEC + NMR data is presented. The methods studied have different drawbacks and advantages. Preparative TREF + SEC + NMR and SEC-FTIR provide most information relative to the labour requirement. In general, the most complete information is obtained from combined interpretation of results from different methods.
Convergence of iterative decoding (1999)

A novel method for visualising the convergence behaviour of iterative decoding schemes is proposed. Each constituent decoder is represented by a mutual information transfer characteristic which describes the flow of extrinsic information through the soft in/soft out decoder. The exchange of extrinsic information between constituent decoders is plotted in an extrinsic information transfer chart. The concepts are illustrated for an iterative demapping and decoding scheme.
HEV Component Sizing and Design Optimization (2011)

In this chapter, four global optimization algorithms are applied in the design optimization of Hybrid Electric Vehicles (HEV). These four algorithms are: DIRECT, Simulated Annealing, Genetic Algorithm, and Particle Swarm Optimization. The principles of the optimization algorithms are thoroughly discussed together with programming flow charts. The four algorithms are used for component sizing of an example parallel HEV. The design goal is to achieve maximum fuel economy subject to constraints of desired vehicle performance. Model in the loop methodology is adopted for our design process, in which a vehicle model named PSAT is used as the analysis tool. The design optimization results and the performance of the four optimization algorithms are compared. Our initial study shows that DIRECT and Simulated Annealing algorithms are efficient for the complex HEV engineering design problem. In addition, Non-dominated Sorting Genetic Algorithm (NSGA-II) is used for multi-objective design optimization of a series HEV.
Efficacy of repifermin (keratinocyte growth factor-2) against abnormalities in gastrointestinal mucosal transport in a murine model of colitis (2003)

Human keratinocyte growth factor-2 (KGF-2) is a member of the fibroblast growth factor family that promotes healing of experimental small intestinal ulceration and colitis. The aim of this study was to determine whether repifermin, a truncated form of recombinant human KGF-2, reverses abnormalities in colonic mucosal transport in a murine model of dextran sulfate sodium (DSS)-induced colitis. Male Swiss-Webster mice were given 4% DSS in drinking water for 7 days and then normal drinking water for 3 days. Repifermin (5 mg kg(-1), i.p.) or vehicle was administered daily for 7 days starting on Day 4 of DSS exposure. On Day 10, net ion transport was measured electrophysiologically in colonic mucosal sheets. Repifermin significantly reduced DSS-induced colonic inflammation measured by tissue myeloperoxidase activity. Concurrently, in colonic tissue taken from mice treated with repifermin, there was a normalization of basal potential difference and short circuit current, and an improvement in the secretory responses to stimulation of muscarinic and ganglionic cholinoceptors. In control mice, repifermin did not interact directly with colonic epithelial cells or intramural neurones to induce immediate changes in net electrogenic transport. The results suggest that repifermin therapy may improve the mucosal electrogenic transport that is impaired during colitis.
Validation of an ear-worn sensor for gait monitoring using a force-plate instrumented treadmill (2011)

A force-plate instrumented treadmill (Hp Cosmos Gaitway) was used to validate the use of a miniaturised lightweight ear-worn sensor (7.4 g) for gait monitoring. Thirty-four healthy subjects were asked to progress up to their maximum walking speed on the treadmill (starting at 5 km/h, with 0.5 km increments). The sensor houses a 3D accelerometer which measures medio-lateral (ML), vertical (VT) and anterior-posterior (AP) acceleration. Maximum signal ranges and zero crossings were derived from accelerometer signals per axis, having corrected for head motion and signal noise. The maximal force, measured by the instrumented treadmill correlated best with a combination of VT and AP acceleration (R-squared = 0.36, p = 0), and combined VT, ML, and AP acceleration (R-squared=0.36, p = 0). Weight-acceptance peak force and impulse values also correlated well with VT and AP acceleration (Weight acceptance: R-squared = 0.35, p = 0, Impulse: 0.26, p = 0), and combined VT, ML, and AP acceleration (Weight acceptance: R-squared = 0.35, p = 0, Impulse: 0.26, p=0). Zero crossing features on the ML axis provided an accurate prediction of the gait-cycle, with a mean difference of 0.03s (-0.01, 0.05 confidence intervals).