gebhart/patrepeval huggingface dataset:
REDOR Determination of the Composition of Shell Cross-Linked Amphiphilic Core−Shell Nanoparticles and the Partitioning of Sequestered Fluorinated Guests (2001)

Rotational-echo double-resonance (REDOR) 13C{19F} and 15N{19F} NMR spectra have been obtained for guest−host complexes of 6-fluorotryptophan and 4-(trifluoromethyl)benzophenone with polymeric amphiphilic nanoparticles, consisting of a polystyrene core covalently attached to a poly(acrylic acid)-co-[15N]polyacrylamide shell. The REDOR spectra were used both to determine the composition of the nanoparticles and to find the locations of the fluorinated guests. Each guest resides near the core−shell interface of the nanoparticle, with the hydrophobic 4-(trifluoromethyl)benzophenone within the core and the amphiphilic 6-fluorotryptophan within the shell.
The membrane-binding domain of a rat liver Golgi sialyltransferase (1987)

Conference Article| August 01 1987 The membrane-binding domain of a rat liver Golgi sialyltransferase JAMES C. PAULSON; JAMES C. PAULSON *Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90024, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar JASMINDER WEINSTEIN; JASMINDER WEINSTEIN *Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90024, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar ERYN L. UJITA; ERYN L. UJITA *Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90024, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar KAREN J. RIGGS; KAREN J. RIGGS *Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, CA 90024, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar POR-HSIUNG LAI POR-HSIUNG LAI †AmGen, 1900 Oak Terrace Lane, Thousand Oaks, CA 91320, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1987) 15 (4): 618–620. https://doi.org/10.1042/bst0150618 Article history Received: February 02 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation JAMES C. PAULSON, JASMINDER WEINSTEIN, ERYN L. UJITA, KAREN J. RIGGS, POR-HSIUNG LAI; The membrane-binding domain of a rat liver Golgi sialyltransferase. Biochem Soc Trans 1 August 1987; 15 (4): 618–620. doi: https://doi.org/10.1042/bst0150618 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: ER, endoplasmic reticulum, ST, β-galactoside α2,6-sialyltransferase This content is only available as a PDF. © 1987 Biochemical Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.
On the Mechanical Reliability of Photo-BCB-Based Thin Film Dielectric Polymer for Electronic Packaging Applications (1999)

This work examines the mechanical performance of thin film coatings from Photosensitive-benzocyclobutene (Photo-BCB) formulations (Cyclotene2 4024, 4026 and 7200), on various substrate surfaces such as Al, Cu, Si, and SiN. The adhesion promoter used was designated AP-3000 and was based on vinyltriacetoxysilane (VTAS), which had been properly hydrolyzed and advanced. Measurement of the interfacial adhesion was performed primarily using the modified Edge Liftoff Test m-ELT. It was found that, by applying the newly developed adhesion promoter, AP-3000, the interfacial energy of Photo-BCB to Al, Cu, Si, and SiN was significantly improved, often approaching the toughness of Photo-BCB, ca. 45 J/m2. The x-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) analyses of the delaminated surfaces of the Photo-BCB/Al structure revealed distinct differences in surface roughness and the chemical composition depending on whether or not adhesion promoter was used. Other parameters important for long term stability (e.g., moisture uptake and thermal stability) of Photo-BCB were also measured. The equilibrium moisture content at 84 percent RH in ambient temperature was low, 0.14 wt percent and the thermally induced weight loss at 330°C in helium atmosphere was less than 1 percent/h. The low moisture absorption and good thermal stability, together with the given mechanical toughness and adhesion, allow the Photo-BCB to be widely usable for various microelectronic packaging applications, for up to 40 μm thick build in the case of silicon substrate. [S1043-7398(00)00701-5]
Crystallization kinetics of a low-expansion feldspar glass for dental applications (1998)

Previous studies have shown that the crystallization of glasses in the system K2O-Al2O3-SiO2, in the primary field of leucite, is not possible without modification of the composition. Leucite (KAlSi2O6) is used as a reinforcing phase in some compositions for all-ceramic dental restorations. However, because of their higher coefficient of thermal expansion, these materials cannot be veneered with conventional metal-ceramic porcelains. The purposes of this study were to investigate the crystallization behavior of a glass in the system K2O-Al2O3-SiO2 and to evaluate the effect of heat treatment on the crystal size, percent crystallinity, and coefficient of thermal expansion of the material. Ion-exchanged glass powder was prepared by mixing the glass with rubidium nitrate and heat-treating at 450 degrees C for 4, 8, 24, or 48 h. Bars were made from these powders and baked under vacuum at 1038 degrees C for 2 min. The bars made from the powder ion-exchanged for 48 h were further heat-treated for 4 h at either 800 degrees C, 850 degrees C, 900 degrees C, 950 degrees C, or 1038 degrees C. X-ray diffraction analyses showed cubic leucite was the only crystalline phase in the specimens made from the powders ion-exchanged for 4, 8, 24, or 48 h and baked at 1038 degrees C for 2 min. Further heat treatment for 4 h at either 800 degrees C, 850 degrees C, 900 degrees C, 950 degrees C, or 1038 degrees C promoted the growth of cubic leucite. In addition, a second phase identified as tetragonal rubidium-leucite was present in the specimens heat-treated for 4 h at 1038 degrees C. SEM observations showed that all specimens made from the powders ion-exchanged for 48 h exhibited small spherical crystals dispersed in a glassy matrix. The percent crystallinity ranged from 18.9% to 42.9% and the average particle size was between 0.64 to 1.18 microns. The coefficients of thermal expansion ranged between 8.076 and 8.788 x 10(-6)/degree C.
SU‐FF‐T‐175: A New Linac QA Procedure for the Characterization of Gantry Radiation Isocenter (2005)

Purpose: A new linac QA method is developed to characterize the size and shape of gantry radiation isocenter. The method accurately measures gantry sag as a function of gantry angles and the size of gantry radiation isocenter in the gantry rotation plane. Method and Materials: In order to determine both sag and radiation isocenter size in the gantry rotation plane we wrap a film (or a phosphor imaging plate) on a cylinder of circumference equal to the film length. We designed a static MLC “dashed line” pattern consisting of regions of radiation along a line. The pattern is designed such that the center of the irradiation line can be easily determined. The cylinder is positioned such that its axis is the same as the gantry rotation axis. The film is exposed to the MLC line pattern for multiple gantry angles. Both entry and exit patterns are seen on the film. A special MLC pattern was designed to accurately characterize the gap between the two ends of the film. An automated analysis program determines the MLC line angles and centers on the film, characterizes the cylinder position and generates the desired gantry radiation isocenter information. Results: The gantry sag is observed to have a smooth dependence on gantry angle with extreme values for 0° and 180°. The smallest circle crossing or tangent to all rays in the gantry rotation plane determines the gantry radiation isocenter size in this plane. The inherent accuracy of the method is estimated at ±/− 0.1 mm. The total irradiation time is about 15 min. The data analysis is less than 5 min. Conclusion: The designed method characterizes both gantry sag and wobble in one simple and accurate test.
The cup fulcrum: a technical tip to improve femoral exposure in total hip arthroplasty. (2008)

An unobstructed view of the proximal femur is a necessity in total hip arthroplasty for proper femoral preparation and to minimize the risk of femoral fractures and damage to the proximal soft tissues. A novel leverage technique is described that uses a trial head and liner to improve femoral visualization for the posterolateral approach. The cup fulcrum technique may minimize the risk of component malposition and damage, femoral fractures, and wound complications. Because there is no additional instrumentation or cost associated with this technique, it should prove useful for all surgeons who perform total hip arthroplasty through the posterolateral approach.
Comparison of Endothelial Progenitor Cells in Parkinson's Disease Patients Treated with Levodopa and Levodopa/COMT Inhibitor (2011)

These data indicate that a higher consumption of EPC for restoration of endothelial damage may be associated with chronic levodopa treatment in PD patients.
Tumor Suppressor CYLD Acts as a Negative Regulator for Non-Typeable Haemophilus influenza-Induced Inflammation in the Middle Ear and Lung of Mice (2007)

Non-typeable Haemophilus influenza (NTHi) is an important human pathogen causing respiratory tract infections in both adults and children. NTHi infections are characterized by inflammation, which is mainly mediated by nuclear transcription factor kappaB (NF-kappaB)-dependent production of inflammatory mediators. The deubiquitinating enzyme cylindromatosis (CYLD), loss of which was originally reported to cause a benign human syndrome called cylindromatosis, has been identified as a key negative regulator for NF-kappaB in vitro. However, little is known about the role of CYLD in bacteria-induced inflammation in vivo. Here, we provided direct evidence for the negative role of CYLD in NTHi-induced inflammation of the mice in vivo. Our data demonstrated that CYLD is induced by NTHi in the middle ear and lung of mice. NTHi-induced CYLD, in turn, negatively regulates NTHi-induced NF-kappaB activation through deubiquitinating TRAF6 and 7 and down-regulates inflammation. Our data thus indicate that CYLD acts as a negative regulator for NF-kappaB-dependent inflammation in vivo, hence protecting the host against detrimental inflammatory response to NTHi infection.
Dipole and slot elements and arrays on semi-infinite substrates (1985)

The printed dipole or slot antenna on a semi-infinite substrate and infinite phased arrays of these elements are investigated. The solution is based on the moment method in the Fourier transform domain. The generalized impedance or admittance matrix can be expressed in rapidly converging infinite-integral or infinite-summation forms, allowing the accurate determination of the current distributions. Using the present formulation, the input impedance, resonant length, and radiation pattern for the isolated antennas, and the reflection coefficient for infinite phased arrays, are calculated.
Reliability Analysis of Structures under Seismic Excitation : Part I : Response ratio of structure having bi-linear spring behavior (1983)

This paper is the first report in a series of papers which concern the reliability analysis of mechanical component mounted on structures. In this paper, nonstationary random responses are obtained for one and two degrees of freedom systems with bi-linear hysteresis restoration force by using Fokker-Plank equation. The effects of the non-linear spring constant, eigenfrequency of the system and predominant frequency of the seismic excitation on the response and magnification factor are investigated.
PERIPROSTATIC ADIPOSE TISSUE AS A MODULATOR OF PROSTATE CANCER AGGRESSIVENESS (2009)

You have accessJournal of Urology1 Apr 2009PERIPROSTATIC ADIPOSE TISSUE AS A MODULATOR OF PROSTATE CANCER AGGRESSIVENESS David S Finley, Valerie S Calvert, Junichi Inokuchi, Alice Lau, Navneet Narula, Frank Zaldivar, Emanuel Petricoin, Darren R. Tyson, and David K Ornstein David S FinleyDavid S Finley More articles by this author , Valerie S CalvertValerie S Calvert More articles by this author , Junichi InokuchiJunichi Inokuchi More articles by this author , Alice LauAlice Lau More articles by this author , Navneet NarulaNavneet Narula More articles by this author , Frank ZaldivarFrank Zaldivar More articles by this author , Emanuel PetricoinEmanuel Petricoin More articles by this author , Darren R. TysonDarren R. Tyson More articles by this author , and David K OrnsteinDavid K Ornstein More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60150-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "PERIPROSTATIC ADIPOSE TISSUE AS A MODULATOR OF PROSTATE CANCER AGGRESSIVENESS." The Journal of Urology, 181(4S), p. 49 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 49 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information David S Finley More articles by this author Valerie S Calvert More articles by this author Junichi Inokuchi More articles by this author Alice Lau More articles by this author Navneet Narula More articles by this author Frank Zaldivar More articles by this author Emanuel Petricoin More articles by this author Darren R. Tyson More articles by this author David K Ornstein More articles by this author Expand All Advertisement PDF downloadLoading ...
Primary and myoma‐associated menorrhagia: role of prostaglandins and effects of ibuprofen (1986)

The release of 6-keto-prostaglandin F1 alpha(6-keto-PGF1 alpha), a metabolite of prostacyclin (PGI2) and thromboxane B2 (TxB2), a metabolite of thromboxane A2 (TxA2), was estimated in endometrial biopsies taken from 12 menorrhagic and 12 healthy women during the luteal phase of the cycle. The releases of 6-keto-PGF1 alpha and TxB2 were normal, but the ratio TxB2/6-keto-PGF1 alpha was inversely related to menstrual blood loss in women with measured menstrual blood loss exceeding 70 ml. In the second part of the study, 24 women with excessive menstrual bleeding (13 with primary menorrhagia, 10 with uterine fibromyomas, one with haemostatic factor VIII deficiency) were treated at random with ibuprofen (600 mg/day and 1200 mg/day) and with a placebo. Ibuprofen 1200 mg/day reduced (P less than 0.01) median blood loss from 146 ml (range 71-374 ml) to 110 ml (30-288 ml) in primary menorrhagia but had no effect on blood loss in women with uterine fibroids and factor VIII deficiency. Blood loss was normal in six women and was not affected by ibuprofen. Thus, our data suggest that there is a PGI2 dominance in the endometrium of patients with menorrhagia. In addition, primary, but neither fibromyoma nor coagulation defect-associated menorrhagia, can be treated by ibuprofen.
Nonlinear Viscoelastic Solids—A Review (2009)

Elastomers and soft biological tissues can undergo large deformations and exhibit time dependent behavior that is characteristic of nonlinear viscoelastic solids. This article is intended to provide an overview of the subject of nonlinear viscoelastic solids for researchers who are interested in studying the mechanics of these materials. The article begins with a review of topics from linear viscoelasticity that are pertinent to the understanding of nonlinear viscoelastic behavior. It then discusses the topics that enter into the formulation of constitutive equations for isotropic, transversely isotropic and orthotropic nonlinear viscoelastic solids. A number of specific forms of constitutive equations have been proposed in the literature and these are discussed. Attention is restricted to constitutive equations that are phenomenological rather than molecular in origin. The emphasis is then on nonlinear single integral finite linear viscoelastic and Pipkin—Rogers constitutive equations, the latter containing the quasi-linear viscoelastic model used in biomechanics of soft tissue. Expressions for the Pipkin—Rogers model are provided for isotropy, transverse isotropy and orthotropy. The constitutive equations are then applied to the description of homogeneous triaxial stretch and simple shear histories. The special case of uniaxial stretch histories is analyzed in detail. There is a discussion of the deviation from linear behavior as nonlinear effects become important. Non-homogeneous deformations are considered next. The combined tension and torsion of a solid cylinder on an incompressible, isotropic nonlinear viscoelastic solid is discussed in detail because of its importance in experiments involving viscoelastic materials. A large number of solutions to boundary value problems have appeared in the literature and many of these are summarized. The article concludes with comments about interesting topics for further research.
Circulating Levels of IL-1B+IL-6 Cause ER Stress and Dysfunction in Islets From Prediabetic Male Mice (2013)

Elevated levels of circulating proinflammatory cytokines are associated with obesity and increased risk of type 2 diabetes, but the mechanism is unknown. We tested whether proinflammatory cytokines IL-1B+IL-6 at low picogram per milliliter concentrations (consistent with serum levels) could directly trigger pancreatic islet dysfunction. Overnight exposure to IL-1B+IL-6 in islets isolated from normal mice and humans disrupted glucose-stimulated intracellular calcium responses; cytokine-induced effects were more severe among islets from prediabetic db/db mice that otherwise showed no signs of dysfunction. IL-1B+IL-6 exposure reduced endoplasmic reticulum (ER) calcium storage, activated ER stress responses (Nos2, Bip, Atf4, and Ddit3 [CHOP]), impaired glucose-stimulated insulin secretion, and increased cell death only in islets from prediabetic db/db mice. Furthermore, we found increased serum levels of IL-1B and IL-6 in diabetes-prone mice at an age before hyperglycemia was exhibited, suggesting that low-grade systemic inflammation develops early in the disease process. In addition, we implanted normal outbred and inbred mice with subcutaneous osmotic mini-pumps containing IL-1B+IL-6 to mimic the serum increases found in prediabetic db/db mice. Both IL-1B and IL-6 were elevated in serum from cytokine-pump mice, but glucose tolerance and blood glucose levels did not differ from controls. However, when compared with controls, isolated islets from cytokine-pump mice showed deficiencies in calcium handling and insulin secretion that were similar to observations with islets exposed to cytokines in vitro. These findings provide proof of principle that low-grade systemic inflammation is present early in the development of type 2 diabetes and can trigger ER stress-mediated islet dysfunction that can lead to islet failure.
ChemInform Abstract: Pd(II) Trifluoroacetate Complexes Containing Chelating Phosphine Ligands: Synthesis, Structures, and Catalysis. (2016)

Abstract Biaryls are prepared by Suzuki—Miyaura coupling of aryl bromides and aryl boronic acids using the title palladium complex as highly active catalyst.
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX‐2, MMP‐9, VEGF and CXCR4 expression in an orthotopic mouse model (2009)

Because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (CRC) is ineffective. Whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of CRC was investigated. The effect of curcumin on proliferation of CRC cell lines was examined by mitochondrial dye-uptake assay, apoptosis by esterase staining, nuclear factor-kappaB (NF-kappaB) by electrophoretic mobility shift assay and gene expression by Western blot analysis. The effect of curcumin on the growth and metastasis of CRC was also examined in orthotopically implanted tumors in nude mice. In vitro, curcumin inhibited the proliferation of human CRC cell lines, potentiated capecitabine-induced apoptosis, inhibited NF-kappaB activation and suppressed NF-kappaB-regulated gene products. In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microvessel density marker CD31. The combination treatment was also highly effective in suppressing ascites and distant metastasis to the liver, intestines, lungs, rectum and spleen. This effect was accompanied by suppressed expression of activated NF-kappaB and NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1, COX-2, ICAM-1, MMP-9, CXCR4 and VEGF). Overall, our results suggest that curcumin sensitizes CRC to the antitumor and antimetastatic effects of capecitabine by suppressing NF-kappaB cell signaling pathway.
Acid- and base-catalyzed deuterium-protium exchange of some polyazaindenes (1968)

The acid-catalyzed deuterium-protium exchange of compounds 1, 2, and 3 occurs at the positions typical for electrophilic substitutions.These substitutions are shown to occur on the free bases. The base-catalyzed deuterium-protium exchange of compounds 1, 2, and 3 occurs at positions adjacent to nitrogen atoms which possess a partial positive charge as indicated by major resonance contributing structures. Proton transfer is shown to be involved in the rate-determining step.
Effect of Oxygen Pressure on the Oxidation of Tungsten Powder. (Studies on the Surface States of Tungsten Powder (4)) (1961)

The oxidation of tungsten in powder form is investigated at the temperature below 400°C and at the oxygen pressure ranging from 10 to 400 mmHg. It is found that the apparent oxidation rate increases with the increase of the oxygen pressure PO2. Applying the model of double oxide layers, as previously described, to the present experimental results, the following facts are observed: (1) For the growth of the thin barrier scale layer, the parabolic rate constant kp increases with PO2n and the activation energy is 29.4 kcal/mol; (2) for the formation of the outer porous layer from the barrier scale, the linear rate constant kl increases with logPO2 and the activation energy is 18.9 kcal/mol. The kinetics of the formation of these layers is discussed and the obtained results are found to be reasonable.
Stereoselective synthesis of sperabillins and related compounds (1991)

Baker's yeast reduction of methyl (4S)-4-(tert-butoxycarbonylamino)-3-oxopentanoate 6 stereoselectively afforded methyl (3R,4S)-erythro-4-Boc-amino-3-hydroxypentanoate 7, which was converted into the erythro keto δ-lactone 3a in three steps. The threo keto δ-lactones 3b–c were diastereoselectively prepared by cyclocondensation of N-Boc D- and L-alaninal 4 with 1 -methoxy-1, 3-bis(trimethylsiloxy)buta-1,3-diene 9 in the presence of a catalytic amount of tin(II) chloride. Recluctive amination of the keto lactones 3 using 5% platinum on carbon as catalyst in an acidic medium stereoselectively afforded the N-protected 3,6-diamino-5-hydroxyheptanoic acid lactones 1 with 3,5-anti stereochemistry. These were transformed into the enantiomerically pure sperabillin 17 and negamycin 20 derivatives in good yields. The configuration of sperabillin B and D was determined to be (3R,5R,6R) by comparison of the synthetic amino lactone 1e with a degradation product of sperabillin B and by the successful transformation of the synthetic amino lactone 1b into sperabillin D.