gebhart/patrepeval huggingface dataset:
Effect of Macromolecular-Translocation Inhibitor-Ill on Binding of Activated Glucocorticoid-Receptor Complex to Specific DNA (1996)

We previously purified macromolecular-translocation inhibitor-III (MTI-III), which inhibits the binding of the activated glucocorticoid-receptor complex (GR) to nuclei, to homogeneity from rat liver, and we found that the purified MTI-III bound to partially purified activated GR under low salt conditions at slightly acidic pH [Liu, G., Okamoto, K., and Isohashi, F. (1993) Eur. J. Biochem. 218, 679-687]. This was the first direct evidence that the inhibitor acts through a direct interaction with the activated GR. In this study, we examined whether the purified MTI-III could interfere with the binding of GR to a DNA fragment containing a specific glucocorticoid-response element (GRE). Under nearly isotonic salt conditions at neutral pH, the activated GR bound to the GRE but not to nonspecific DNA. Under similar conditions, the activated GR also bound to the purified MTI-III. The resulting GR/MTI-III complex did not bind to the GRE. We also found that addition of MTI-III to the GR/GRE complex resulted in time-dependent disruption of the GR/GRE complex and formation of the GR/MTI-III complex. The half-life of the GR/GRE complex in the presence of MTI-III was about 13 min. These results suggest that MTI-III enhances the release of GR from the GR/GRE complex and immediately forms a stable GR/MTI-III complex.
Dynamics of a Vibro-Impacting Hinged Beam: Rigid and Flexible Models (1999)

Abstract This study investigates the behavior of a vibro-impacting system with a rigid body mode. The model problem has been formulated as both a one-DOF and a multi-DOF piecewise linear system. The behavior of the models for a base excitation frequency range of 50–200 Hz (4.9–19.5% of the fundamental natural frequency of the in-contact case) is shown for constant base motion acceleration and displacement. It is seen that the models do not predict the same motion for the constant acceleration case, but agree quite closely for the constant displacement case. The system is capable of chaotic motion and several examples of Poincaré sections are shown which suggest the presence of a strange attractor. Future work including analytical methods of analysis for both the one- and multi-DOF systems is discussed.
Adhesion/Stiction and Friction Studies of Nano/Micro-Textured Surfaces Produced by Crystallization of Amorphous Silicon (2005)

This paper reports a new method of nano/micro surface-texturing and the results of systematic studies of adhesion/stiction and friction properties on the textured surfaces produced by this method. Nano/micro-textured surfaces with various roughnesses were produced by low temperature aluminum-induced crystallization of plasma enhanced chemical vapor deposited (PECVD) amorphous silicon. Adhesion/stiction experiments on these nano/microtextured and non-textured surfaces were performed using two diamond tips under predefined displacement profiles with different maximum indentation displacements. Friction experiments on the textured and non-textured surfaces were conducted using the same tips under various normal contact forces. The adhesion/stiction forces and coefficients of friction (COF) of the textured surfaces were found to be much smaller than those of non-textured surfaces.
Optimiization of Coded MIMO-Transmission with Antenna Selection (2005)

The performance of a wireless system can be significantly improved by using multiple antenna elements at the transmitter and/or the receiver side. The major problems of such systems are high cost and complexity due to more than one radio frequency (RF) chains at both end links. An effective technique to reduce this overhead is to allow the transmitter and/or the receiver to select an optimum antenna subset according to some optimization criterion. In this paper, we analyze coded multiple-input/multiple output (MIMO) systems with antenna selection at the transmitter side. We propose an optimum selection criterion to minimize the bit error ratio (BER) when a channel adapted quasi-orthogonal space time code (QSTBC) and a low complexity zero forcing receiver (ZF) are used. We show that antenna selection is a promising low-cost technique that provides additional diversity and coding gain and therefore improves the system performance even if the simple linear receiver is used.
ChemInform Abstract: A Metal‐Free Approach for Transamidation of Amides with Amines in Aqueous Media. (2015)

Abstract The title method furnishing amides in excellent yields can be carried out under microwave irradiation as well as conventional heating conditions.
Echocardiographic criteria for detection of postinfarction congestive heart failure in rats (2000)

We evaluated postinfarction myocardial function in rats and determined echocardiographic criteria for congestive heart failure (CHF) using high performance echocardiography. Extensive myocardial infarction (MI) was induced in rats by left coronary occlusion. Sham-operated animals served as controls. Five weeks later, high-frame rate ( approximately 200 Hz), fully digitized, shallow-focus (10-25 mm), two-dimensional, M-mode and Doppler echocardiography was performed. A J-tree cluster analysis was performed using parameters indicative of CHF. Reproducibility was examined. The cluster analysis joined the animals into one Sham and two MI clusters. One of the MI clusters had clinical characteristics of CHF and elevated left ventricular end diastolic pressure. Among the echocardiographic variables, only posterior wall shortening velocity separated the failing and nonfailing MI clusters. We conclude that, by high frame rate echocardiography, it is possible to obtain high- quality recordings in rats. It is feasible to distinguish MI rats with CHF due to myocardial dysfunction from those without failure and to perform longitudinal studies on myocardial function.
Role of Angiotensin II in the Regulation of a Novel Vascular Modulator, Hepatocyte Growth Factor (HGF), in Experimental Hypertensive Rats (1997)

Hepatocyte growth factor (HGF) is a mesenchyme-derived pleiotropic factor that regulates cell growth, cell motility, and morphogenesis of various types of cells, and is thus considered a humoral mediator of epithelial-mesenchymal interactions responsible for morphogenic tissue interactions. We have previously reported that HGF is a novel member of endothelium-specific growth factors whose serum concentration is positively associated with blood pressure in humans. Therefore, we speculated that serum HGF secretion might be elevated in response to high blood pressure as a counter-system against endothelial dysfunction. However, it is difficult to elucidate the role of circulating and tissue HGFs in human hypertension. To address this issue, we measured circulating and tissue HGF concentrations in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) at different ages. Serum HGF concentration in SHR was significantly higher than that in WKY at 6, 15, and 25 weeks of age (P<.01). Serum HGF concentration was also significantly positively correlated with blood pressure in SHR (P<.02, r=.455). In contrast, tissue HGF concentrations in heart, aorta, and kidney were significantly decreased in SHR as compared with WKY at 25 weeks of age, when these organs showed hypertrophic changes induced by hypertension (P<.01). Cardiac HGF mRNA was also decreased in SHR as compared with WKY at 25 weeks of age. Moreover, cardiac HGF concentration showed a significant negative correlation with left ventricular (LV) weight (P<.01), whereas serum HGF concentration showed a significant positive correlation with LV weight (P<.05). Interestingly, concentrations of cardiac and vascular angiotensin II, a suppressor of HGF, were increased in SHR as compared with WKY at 25 weeks of age (P<.01). Therefore, we examined the effects of angiotensin blockade on circulating and tissue HGF concentrations, to study the role of angiotensin II in HGF regulation. Administration of an angiotensin-converting enzyme inhibitor (enalapril) and angiotensin II type 1 receptor antagonists (losartan and HR 720) for 6 weeks resulted in a significant increase in cardiac HGF concentration, accompanied by increased cardiac HGF mRNA, and a significant decrease in serum HGF concentration, accompanied by lowered blood pressure and reduced LV weight (P<.01). Here, we demonstrated increased circulating HGF and decreased vascular, cardiac, and renal HGF in SHR as compared with WKY at the maintenance stage of hypertension. Decreased tissue HGF in target organs of hypertension may be due to increased tissue angiotensin II. These results suggest that decreased local HGF production may have an important role in the cardiovascular remodeling of target organs in hypertension, since HGF prevented endothelial injury and promoted angiogenesis. Blockade of angiotensin augmented local decreased cardiovascular HGF in hypertension, potentially resulting in the improvement of endothelial dysfunction.
Correction: <i>MYC</i> amplifications in myeloma cell lines: correlation with MYC-inhibitor efficacy (2018)

[This corrects the article DOI: 10.18632/oncotarget.4245.].
Performance estimation of UMTS release 5 IM-subsystem elements (2003)

Universal Mobile Telecommunications System (UMTS) is the third generation (3G) mobile communications systems specified by the European Telecommunications Standards Institute (ETSI) and the world-wide 3G Partnership Project (3GPP) within the framework defined by the International Telecommunication Union (ITU) and known as International Mobile Telecommunications-2000 (IMT-2000). ETSI and 3GPP are introducing UMTS in phases and annual releases. UMTS is a 3G GSM successor standard using the GSM phase 2+ enhanced core networks. Currently, there is an evolution from GSM phase 2+ core network towards the UMTS release 5 multiservice packet network. This process is characterized by creating the Internet Protocol (IP) multimedia core network subsystem (IM-subsystem), which includes elements necessary to support IM services in UMTS. Traffic patterns generated by IM services are different from traditional Poisson models used for circuit switched voice traffic. As a result, network parameters can be underestimated, and a UMTS network planning problem arises. For successful solution of the problem, it is necessary to estimate the performance of IM-subsystem elements. We analyze the performance of the gateway GPRS support node (GGSN) on the basis of the FBM/D/1/W queueing system (FBM - fractional Brownian motion). Submitted results may be applied for the estimation of parameters of UMTS release 5 IM-subsystem elements.
Physiologic Pharmacokinetic Modeling of Gastrointestinal Blood Flow as a Rate-Limiting Step in the Oral Absorption of Digoxin: Implications for Patients with Congestive Heart Failure Receiving Epoprostenol* (1996)

A previously validated physiologically based pharmacokinetic model was used to examine whether epoprostenol-induced increases in gastrointestinal blood flow (Qg) could alter digoxin systemic bioavailability to a clinically significant extent in severe congestive heart failure (CHF) patients. A series of simulations was conducted in which the influences of apparent gut tissue-to-plasma partition coefficient (Kg) and Qg on digoxin bioavailability were evaluated. Since epoprostenol also increases blood flow to the liver and kidneys, the effect of concurrent increases in regional blood flow to these organs on digoxin bioavailability also was evaluated. A range of Qg was studied from 25 L/h (assumed mesenteric arterial low in CHF) to 65 L/h (portal venous flow in normal adults), and the area under the simulated digoxin concentration–time curve was used to calculate absolute digoxin bioavailability in each case. Simulations were onducted at a range of Kg from 1 to 50 (physiologically relevant range 5–25). At low values of Kg, the influence of changes in Qg on digoxin bioavailability was minimal. However, as apparent distribution into gut tissue increased (consistent with visceral congestion), the effect of changes in Qg was more substantial. In the physiologically relevant range of Kg, 40–160% increases in Qg were associated with approximately 6–40% increases in digoxin bioavailability. Therefore, the decrease in digoxin oral clearance previously observed in CHF patients receiving epoprostenol may be ascribed to increases in digoxin bioavailability, secondary to epoprostenol-induced increases in Qg.
A feasibility study evaluating innovative in-ear pulse oximetry for unobtrusive cardiovascular homecare monitoring during sleep (2013)

In this paper, we present a novel pulseoximetric sensor which can be worn in the ear channel. In previous work, we could demonstrate that measurement of heart rate (HR), arterial oxygen saturation (S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) and respiratory related information can be performed with reliable accuracy. Since these results were obtained under laboratory conditions, we now studied the feasibility of a clinical appliance of the sensor system for cardiovascular monitoring during sleep which may allow diagnosis of sleep apnea in future. Therefore, we performed human trials in a sleep laboratory with patients with a clinical suspicion of sleep apnea. The evaluation focus on heart rate and oxygen saturation. Results was compared with standard polysomnography (PSG) measurements and demonstrate that nocturnal long-term measurement of oxygen saturation and heart rate is possible with sufficient accuracy.
Enhanced flux, erosion resistant membranes for biomass separations — Part I (2004)

This feature concerns erosion mechanisms of ultrafiltration and microfiltration membranes, and a novel concept termed an ‘embedded membrane’. In the first instalment of this two-part article, which appears here, we provide an introduction to the research and details of the membrane samples under investigation. The visual inspection of the interior surfaces of the membranes, and the results of scanning electron microscope analyses and energy dispersive spectroscopy are also described.
Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition (2015)

These data indicate that NF-κB/RelA controls a SMAD-independent gene network whose regulation is required for initiation of Type II EMT. Type II EMT dramatically affects the induction and kinetics of TNF-dependent gene networks.
Investigation of electric characteristics of contact assemblages with a powder damping interlayer (2009)

In our work there were investigated thermal electrophysical characteristics of coaxial contact assemblages, made of a steel current carrying rod, steel or cermet sleeve and filled with an iron or nichrome powder. As a result of heating up to 950 oС the iron powder was shown to be sintered and develop a highly conductive and damping medium that can be used for making contact junctions of materials having very different linear expansion coefficients.
A Case of Primary Adenosquamous Carcinoma of the Liver Presented with Liver Abscess (2001)

Primary adenosquamous carcinoma of the liver is a very rare type of cholangiocarcinoma and is defined as a cancer containing both squamous and adenomatous components in the same lesion. Recently, we experienced a primary adenosquamous carcinoma of the liver presented as liver abscess. A 63-year-old man was presented with a 4-day history of fever and chill. The radiologic study showed a 4 cm-sized, central hypoattenuated mass with peripheral rim enhancement in the left lobe of the liver. Ultrasonography-guided aspiration and biopsy suggested an adenocarcinoma with abscess in the liver. At laparotomy, the tumor occupied the left lobe of the liver and invaded the right diaphragm. An extended left lobectomy and a partial excision of the involved diaphragm were done. Grossly, the tumor was 6 x 5 x 5 cm in size and had an eccentric necrosis. Microscopically, the tumor was composed of adenocarcinoma and squamous cell carcinoma with a transitional area.
A novel passive microfluidic device for preprocessing whole blood for point of care diagnostics (2009)

A novel strategy to sort the cells of interest (White Blood Cells (leukocytes)) by selectively lysing the Red Blood Cells (erythrocytes) in a miniaturized microfluidic device is presented. Various methods to lyse cells on a chip exist i.e. electrical, mechanical, chemical and thermal but they need integration of electrodes, traps, reservoirs, heaters, etc which is often difficult at microscale. On the other hand, FACSlyse protocol uses only osmotic pressure to lyse erythrocytes allowing further isolation of leukocytes. This motivated us to develop a novel herringbone based lyser which works on the principle of mixing whole blood with pure water in time controlled manner to lyse erythrocytes osmotically on a chip.
Profile of Polyphenolic and Essential Oil Composition of Polish Propolis, Black Poplar and Aspens Buds (2018)

In this work, we studied similarities and differences between 70% ethanol in water extract (70EE) and essential oils (EOs) obtained from propolis, black poplars (<i>Populus nigra</i> L.) and aspens (<i>P. tremula</i> L.) to ascertain which of these is a better indicator of the plant species used by bees to collect propolis precursors. Composition of 70EE was analyzed by UPLC-PDA-MS, while GC-MS was used to research the EOs. Principal component analyses (PCA) and calculations of Spearman's coefficient rank were used for statistical analysis. Statistical analysis exhibited correlation between chemical compositions of propolis and <i>Populus</i> buds' 70EE. In the case of EOs, results were less clear. Compositions of black poplars, aspens EOs and propolises have shown more variability than 70EE. Different factors such as higher instability of EOs compared to 70EE, different degradation pattern of benzyl esters to benzoic acid, differences in plant metabolism and bees' preferences may be responsible for these phenomena. Our research has therefore shown that 70EE of propolis reflected the composition of <i>P. nigra</i> or complex aspen⁻black poplar origin.
Further studies on satellite nucleoli of lymphocytes in patients suffering from B chronic lymphocytic leukaemia. (1994)

Satellite nucleoli were studied in lymphocytes of patients suffering from various stages of B chronic lymphocytic leukaemia without and after treatment with cytostatic monotherapy with chlorambucil. The percentage of lymphocytes with satellite nucleoli in the peripheral blood of investigated patients was very constant and showed only a statistically non-significant slight trend to decrease in the most advanced stage of the disease. In contrast, the count of these cells increased in advanced stages of the disease, and decreased after the cytostatic chemotherapy. From the methodological point of view, satellite nucleoli may be easily visualized by means of a simple staining for RNA with acidified basic dyes without fixation. Such staining provided similar results as cytochemical immunoreactions for the characteristic nucleolar protein B23.
Evaluation of Resistance of Four Strains of Commercial Laying Hens to Experimental Infection with Salmonella enteritidis Phage Type Eight (1994)

Four different strains of White Leghorn hens were orally infected with 1 x 10(8) cfu of Salmonella enteritidis phage Type 8 per bird. The birds were monitored for 10 wk postinfection for colonization of internal organs, fecal shedding of S. enteritidis, and the production of S. enteritidis-contaminated eggs. There was no difference among the four hen strains in regards to the probability of S. enteritidis isolation from liver and spleen, ovary, and cecal tissue within the first 30 d postinfection. However, during the first 14 d postinfection, S. enteritidis organisms were isolated in significantly higher rates from eggs and fecal samples of Strain A than from samples obtained from the other three hen strains. Results suggest that there may be inherent differences between strains of laying hens with regard to their response to infection with S. enteritidis.
Adaptive-based distributed cooperative multi-robot coverage (2011)

In this paper we present a solution to the problem of positioning a team of mobile robots for a surveillance task in a non-convex environment with unknown obstacles. The problem is addressed taking into account several physical and environmental constraints like limited sensor capabilities, obstacle-avoidance, etc. The goal is to maximize the area monitored by the team, by identifying the best configuration of the team members. Due to the non-convex nature of the problem, an analytical solution cannot be obtained. The proposed method is based on a new cognitive-based, adaptive optimization algorithm (CAO). This method allows getting coordinated and scalable controls to accomplish the task. Furthermore, we propose a different formulation of the problem in order to obtain a distributed solution which allows us to consider also limited communication capabilities. Extensive simulations are presented to evaluate the efficiency of the proposed algorithm and to compare centralized and distributed approach.
A Rapid Microdistillation Method for the Texas and Turkish Salvia Species and Their Genetic Profiles (2009)

A Phase 2 clinical trial with Black Cohosh and Red Clover was conceived in 2000 within our UIC/NIH Center for Botanical Dietary Supplement Research on Womens Health. Prior to implementing the trial, a Phase 1 study was required and approval from FDA that an IND application was not required since the end point being measured was reduction in hot flashes in menopausal women. Menopause, for purposes of FDA is not considered a disease. The study was delayed for more than a year in order to prepare a botanically authenticated and chemically and biologically standardized extract. It was ascertained that the biological endpoint for purposes of the study would be interaction with certain serotonin receptors, in vitro. The study preparations had to be formulated and were subjected to accelerated stability studies. During the recruitment of suitable subjects the results of the WHI (Womens Health Initiative) caused difficulty in the ability to recruit suitable women since the study had four arms, i.e. Black Cohosh, Red Clover, Placebo and Prempro and many women were reluctant to enter the trial if there was a possibility that there would be taking Prempro. Because of this, only 88 subjects were recruited of the 128 initially planned. However, the study was powered sufficiently if the dropout rate was less than 15 %. In the final analysis, Red Clover was shown to positively affect cognition but neither test preparation reduced hot flashes. A discussion of these results will be presented.