gebhart/patrepeval huggingface dataset:
Are Females More Susceptible to EGCG Induced Hepatotoxicity? (2014)

Many recent studies and case reports have implicated Epigallocatechin-3-gallate (EGCG) to be hepatotoxic. As females consume weight control medications more than males, they are relatively more exposed to the harmful effects of EGCG on their livers. This study was conducted to assess the effect of EGCG in female mice either under normal or inflammatory conditions induced by lipopolysaccharide (LPS). Some biochemical parameters associated with liver functions were assessed. Also, survival of mice was studied and histopathological examination of liver samples was performed. Administration of lower IG doses of EGCG in normal female mice did not show any harmful effect on liver, however, administration of higher IG doses of EGCG in normal conditions was associated with an early stage of hepatotoxicity. Under inflammatory conditions, the effect of administration of EGCG on liver was severe. The results presented in this study suggest that females were susceptible to risk of liver injury, especially under an inflammatory insult as histopathology showed severe acute liver injury. In our previous study with male mice (published earlier), histopathology was relatively less severe. This may suggest that females are relatively more susceptible to EGCG induced liver injury than males. Keywords-Green Tea (GT), Epigallocatechin-3-gallate (EGCG),Lipopolysaccharide (LPS), Inflammation, Hepatotoxicity.
Influence of eugenol-containing temporary cement on bonding of self-etching adhesives to dentin. (2006)

Previous contact with zinc oxide-eugenol cement did not decrease the bond strength of resin composite to dentin mediated by self-etching adhesives. This finding suggests that eugenol-containing temporary cements may be safe to use in combination with self-etching adhesives.
Low-frequency internal friction of foamed Al (1998)

Abstract The low-frequency damping properties of foamed Al have been studied. The internal friction of foamed Ál obviously increases with an increase in porosity and a decrease in pore size, is nearly independent of frequency and typically depends on strain amplitudes. Based on the observed experimental phenomena, a damping mechanism is presented. According to the damping mechanism, the effects of pores and strain amplitude on internal friction have been analysed in detail and the experimental results have been better explained.
ChemInform Abstract: Design and Synthesis of Indan‐ureido‐thioisobutyric Acids: A Novel Class of PPARα Agonists. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Pseudomonas aeruginosa outer membrane protein I vaccine: immunogenicity and safe administration in man. (1997)

After expression in Escherichia coli and purification by Ni++ chelate-affinity chromatography, the outer membrane protein I (OprI) of Pseudomonas aeruginosa was tested in experimental animals for its safety and pyrogenicity. Four groups of 7 adult human volunteers were then vaccinated 3 times at four-weekly intervals with either 500 micrograms, 200 micrograms, 50 micrograms or 20 micrograms of OprI adsorbed onto aluminum hydroxide. The vaccinations were well tolerated and without systemic side effects, but a significant rise of antibody titers against OprI was measured in the serum of those who had received the 500 micrograms, 200 micrograms or 50 micrograms doses. Raised antibody titers against OprI were still present 30 weeks after the final vaccination. It was possible to demonstrate binding of the complement component C1q to the elicited antibodies, and this confirms their ability to promote antibody-mediated complement-dependent opsonization.
Direct observation of space charges in barium titanate (1990)

Abstract We report dielectric measurements as a function of temperature (20°C<T<200°C) and frequency (5Hz < f <107Hz) in pure and doped BaTiO3. The very low frequency dispersion of the complex dielectric constant arises from space charges.
5‐Isoxazolylhydrazines. Reduction of 5‐isoxazolones to isoxazoles (1969)

Abstract 5‐Isoxazolylhydrazines III were obtained from 5‐isoxazolones I, via the 5‐haloisoxazoles II. The decomposition of the tosyl derivatives of III results in unambigous syntheses of 3,4‐disubstituted isoxazoles.
Détermination combinée des constantes et enthalpies de formation de complexes métal-coordinat multifonctionnel par couplage de la calorimétrie à la potentiométrie. (1994)

La complexation des ions cuivre (II) et nickel (II) par le glutathion oxydé d'une part, et deux dipeptides (glycyl-glycine et glycyl-méthionine) d'autre part, a été étudiée par calorimétrie couplée à la potentiométrie à 25 °C en milieu KNO3 0,5 mol dm-3 pour les dipeptides et en milieu 0.15 mol dm-3 pour le glutathion oxydé.
Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma (2001)

Loss of heterozygosity and microsatellite instability, which reflect inactivation of tumor-suppressor genes and genomic instability, occur with increased frequency in HIV-associated squamous-cell carcinoma. These data demonstrate for the first time evidence of loss of heterozygosity at the APC and DCC/SMAD4 gene loci in anal carcinoma. Although the findings presented here need to be expanded in a larger study, the recurrent loss of heterozygosity at D2S123, which was demonstrated in HIV-positive patients with radio-resistant squamous-cell carcinoma of the anus, is notable.
Design, Synthesis, Conformational Analysis and Application of Azabicycloalkane Amino Acids as Constrained Dipeptide Mimics (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Other people's data (2009)

Companies have access to more types of external data than ever before. How can they integrate it most effectively?
Dynamic stereochemistry of tetra-o-tolylcyclopentadienone (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamic stereochemistry of tetra-o-tolylcyclopentadienoneRudolph Willem, Henri Pepermans, Cornelis Hoogzand, Klaas Hallenga, and Marcel GielenCite this: J. Am. Chem. Soc. 1981, 103, 9, 2297–2306Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/ja00399a027https://doi.org/10.1021/ja00399a027research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Treatment of viral hepatitis (1992)

Major advances have been made in our understanding of the etiology and disease processes of viral hepatitis, a collection of diseases caused by five distinct agents. Approved treatments for the chronic diseases caused by hepatitis B virus and hepatitis C virus are now a reality, although much more progress is needed to extend the benefits to a larger population of these carriers. The rapid pace of research on the virology of these agents, the availability of modern tools of molecular biology, and the potential for development of both in vitro and in vivo models in which to conduct preclinical studies, bodes well for future control of these serious and progressive diseases.
Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue (2003)

The reciprocal association of adiponectin and CRP levels in both human plasma and adipose tissue might participate in the development of atherosclerosis.
Internet-based calibration of a multifunction calibrator (2000)

A new way of providing calibration services is evolving which employs the Internet to expand present capabilities and make the calibration process more interactive. Sandia National Laboratories and the National Institute of Standards and Technology are collaborating to set up and demonstrate a remote calibration of multifunction calibrators using this Internet-based technique that is becoming known as e-calibration. This paper describes the measurement philosophy and the Internet resources that can provide real-time audio/video/data exchange, consultation and training, as well as web-accessible test procedures, software and calibration reports. The communication system utilizes commercial hardware and software that should be easy to integrate into most calibration laboratories.
Addukte aus dem Keten (1<i>E</i>,3<i>Z</i>)‐1,2,3,4,5‐Pentamethyl‐6‐oxo‐1,3,5‐hexatrienylacetat (1984)

Die Addition von Cyclohexylamin an ein permethyliertes Dienylketen ergibt rac ‐ 1 und rac ‐ 2 (Röntgen‐Strukturanalyse). Mit üblichen spektroskopischen Daten läßt sich nicht entscheiden, ob 1,2‐, 1,4‐ oder 1,6‐Addukte vorliegen. Dies ist jedoch durch die neue NMR‐Technik möglich, die im nachstehenden Beitrag beschrieben wird. magnified image
An E3‐14.7K Peptide that Promotes Microtubules‐Mediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency (2013)

Chemical vectors as cationic polymers and cationic lipids are promising alternatives to viral vectors for gene therapy. Beside endosome escape and nuclear import, plasmid DNA (pDNA) migration in the cytosol toward the nuclear envelope is also regarded as a limiting step for efficient DNA transfection with non-viral vectors. Here, the interaction between E3-14.7K and FIP-1 to favor migration of pDNA along microtubules is exploited. E3-14.7K is an early protein of human adenoviruses that interacts via FIP-1 (Fourteen.7K Interacting Protein 1) protein with the light-chain components of the human microtubule motor protein dynein (TCTEL1). This peptide is conjugated with pDNA and mediates interaction of pDNA in vitro with isolated microtubules as well as with microtubules in cellulo. Videomicroscopy and tracking treatment of images clearly demonstrate that P79-98/pDNA conjugate exhibits a linear transport with large amplitude along microtubules upon 2 h transfection with polyplexes whereas control pDNA conjugate exhibits small non-directional movements in the cytoplasm. Remarkably, P79-98/peGFP polyplexes enhance by a factor 2.5 (up to 76%) the number of transfected cells. The results demonstrate, for the first time, that the transfection efficiency of polyplexes can be drastically increased when the microtubules migration of pDNA is facilitated by a peptide allowing pDNA docking to TCTEL1. This is a real breakthrough in the non viral gene delivery field that opens hope to build artificial viruses.
Temperature dependent operation of the vertical cavity surface emitting laser (1994)

The temperature dependence of the vertical cavity surface emitting laser is evaluated using a laser model based on the no-k selection rule. The predictions indicate that the temperature for the minimum threshold current has a substantial dependence on the loss in the laser, represented by the photon lifetime, which is in agreement with experimental findings. Using the Fermi energies as parameters to connect the carrier densities at threshold to the lasing frequency, a family of design curves, which are dependent only on the laser cavity dimension and a universal loss parameter K, is produced. Since K encompasses all significant design variables, the design tool enables a compromise to be chosen between the magnitude of the threshold current and its required temperature sensitivity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification and Characterization of a Psychrophilic Yeast Strain Newly Isolated from the Fermentative Starter (Loog-pang) of a Traditional Drink in Thailand (2009)

One psychrophilic yeast strain, that grew well in a cold environment such as in a refrigerator, was isolated from the yeast starter (Loog-pang) of a traditional alcohol drink in Thailand. The isolated strain OPU-FC11 was identified as Cryptococcus diffluens by the assay for 26S ribosomal DNA and the test for carbon source assimilation. OPU-FC11 showed a good amount of growth at 4°C at which a commonly found yeast like Saccharomyces cerevisiae did not grow, and produced cold-adapted enzymes that showed a relatively high activity at lower temperatures.
Vineberg procedure for inadvertent injury to anomalous left anterior descending artery during tetralogy of fallot repair: four decades later. (2006)

A 41-year-old man underwent diagnostic coronary angiography for the evaluation of chest pain. In 1965 (at the age of 2 years), he had undergone tetralogy of Fallot repair that had been complicated by accidental damage to the left anterior descending coronary artery (LAD), which arose anomalously from the right sinus of Valsalva (RSV) and crossed the right ventricular outflow tract. At that time, he underwent direct implantation of the left internal mammary artery into the left ventricular myocardium (Vineberg procedure) as a remedy.

The coronary angiogram showed a patent right coronary artery, a patent anomalous left circumflex artery arising from the RSV, and an occluded anomalous LAD from the RSV, which was reconstituted by collateral vessels from the left circumflex artery (Fig. 1). The left internal mammary artery that had been implanted directly into the left ventricular myocardium was found to be atretic (Fig. 2). The left ventricular ejection fraction was estimated at 0.50, with mild septal hypokinesis. Medical treatment was advised for the patient.



Fig. 1 Left anterior oblique view shows an occluded left anterior descending coronary artery (arrows) reconstituted by collateral vessels from the left circumflex artery.





Fig. 2 The left internal mammary artery (LIMA) graft that was implanted directly into left ventricular myocardium (Vineberg procedure) was atretic (arrow).
Maesaquinone: A Novel Inhibitor of Plant Mitochondrial Respiratory Enzymes That React with Ubiquinone (2000)

The effect of maesaquinone, 2-(14-nonadecenyl)-3,6-dihydroxy-5-methyl-1,4-benzoquinone, on plant mitochondrial respiration has been investigated. In mitochondria isolated from thermogenic Arum maculatum spadices, this compound inhibits both cytochrome and alternative pathway activities. Kinetic analyses reveal that this inhibition is the result of potent effects of maesaquinone on the alternative oxidase (ID50 < 0.3 microM) and complex III (ID50 < 5 microM). Succinate dehydrogenase and external NADH dehydrogenase are also inhibited, albeit to a lesser extent (approximately 30% at 1 microM). These data suggest that maesaquinone specifically affects the interaction of the respective enzymes with ubiquinone.
Giant Up-Conversion Efficiency of InGaAs Quantum Dots in a Planar Microcavity (2014)

Self-assembled InGaAs quantum dots (QDs) were fabricated inside a planar microcavity with two vertical cavity modes. This allowed us to excite the QDs coupled to one of the vertical cavity modes through two propagating cavity modes to study their down- and up-converted photoluminescence (PL). The up-converted PL increased continuously with the increasing temperature, reaching an intensity level comparable to that of the down-converted PL at ~120 K. This giant efficiency in the up-converted PL of InGaAs QDs was enhanced by about 2 orders of magnitude with respect to a similar structure without cavity. We tentatively explain the enhanced up-converted signal as a direct consequence of the modified spontaneous emission properties of the QDs in the microcavity, combined with the phonon absorption and emission effects.
Exploration of Sn70Li30 alloy as possible material for flowing liquid metal plasma facing components (2020)

As an advanced alternative to solid materials, Liquid Metals (LM) may offer more resilient and feasible Plasma Facing Components (PFCs). Particularly, regarding the unavoidable material erosion/degradation produced by particle/heat fluxes in future fusion devices where much longer duty cycles are expected. Furthermore, configurations that propose a flowing LM surface can add the advantage of a continuously fresh and clean layer facing the plasma. Although lithium is the most widely tested option, tin-lithium (SnLi) alloys have been proposed to attempt to combine the positive characteristics of both pure elements and ameliorate the specific issues of lithium. In this work, the potential use of Sn70Li30 alloy in such flowing concepts has been explored by addressing several preliminary and mandatory aspects for its utilization. Key issues such as wettability and compatibility of the alloy with relevant substrates have been studied in a multidisciplinary approach. The data obtained from deposited liquid tin-lithium droplets indicates approximate wetting temperatures of 360 °C, 390 °C and 405 °C for the fresh alloy on 316 stainless steel, molybdenum, and tungsten, respectively. However, the alloy contamination appeared to strongly affect the wetting characteristics of materials, increasing their wetting temperature by ~130 °C in the worst observed cases. Interestingly, in some instances, the instability of the liquid alloy surface was observed in the form of sudden gaseous ejection. The deposited droplets were posteriorly characterized in terms of absolute composition and depth profile by Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) and Secondary Ion Mass Spectrometry (SIMS-ToF). Additionally, the nature and composition of the boundaries between the substrates and alloy microparticles was investigated by Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Spectroscopy (EDS), and 3D Laser microscopy. The overall results of this post-mortem characterization revealed that first signs of corrosion induced by both alloy elements (lithium-chromium association and iron-tin intermetallic mixing) were present on 316 stainless steel after short exposures (≤3 h) at temperatures lower than 550 °C. Conversely, molybdenum and tungsten showed good compatibility with the alloy in equivalent conditions. The global implications of these results are finally addressed, focusing on the future perspectives and the more viable scenarios for the eventual utilization of these alloys in flowing liquid metal configurations.
Activity of AT13387, a novel, non-ansamycin inhibitor of heat shock protein 90, against gastrointestinal stromal tumors (GIST). (2013)

105 Background: AT13387 is a second-generation potent, novel non-ansamycin HSP90 inhibitor (Kd 0.71nM). The majority of GIST tumors are characterized by activating mutations of c-KIT, an HSP90 client protein. Secondary resistance mutations within c-KIT limit clinical responses to TKIs. The dependence of c-KIT and its mutated forms on HSP90 suggests that HSP90 inhibition may be a valuable treatment option for imatinib-sensitive and resistant clones. In vitro, AT13387 inhibited the proliferation of imatinib-sensitive (GIST882, GIST-T1) and imatinib-resistant (GIST430, GIST48) cell lines. In vivo, AT13387 demonstrated anti-tumor activity in the imatinib-sensitive (GIST-PSW) and imatinib-resistant (GIST430) xenograft models. Induction of HSP70, depletion of phospho-c-KIT and inhibition of c-KIT signaling were observed in both models. Combination treatment of imatinib and AT13387 in the GIST430 model was well tolerated and significantly enhanced tumor growth inhibition over either monotherapies. Methods: In a completed phase I study, AT13387 was administered IV over 1 hour twice weekly or weekly of a 28-day cycle in a standard 3+3 dose-escalation design. The primary endpoint was to determine the MTD; secondary endpoints included PK, PD, safety and tolerability. Results: The PK exposures were dose-dependent and linear. AT13387 was well tolerated on both schedules. DLTs included primarily G2 AEs of GI toxicities, fatigue and infusion site reactions. The once weekly RP2D was determined to be 260 mg/m 2 . HSP70 induction was 2–7 fold at higher doses. A total of 7 GIST subjects were enrolled. An objective and durable PR was observed in one subject and 2 SDs at 8, 7 and 11 months, respectively. The PR subject demonstrated molecular resistance to kinase inhibitor treatment in the c-KIT gene prior to initiation of AT13387 therapy in two resected lesions by harboring the same activating c-KIT deletion in exon 11 and two separate TKI resistance mutations in exon 17. Conclusions: Overall, these results suggest AT13387 is a promising agent in GIST, including TKI-resistant c-Kit positive GIST. AT13387 is currently being evaluated in combination with imatinib in an ongoing phase I/II study. Clinical trial information: NCT01294202.
The Stability of Human Chorionic Gonadotropin in Urine and of Reagents for the Slide Immunologic Test for Pregnancy (1965)

The Stability of Human Chorionic Gonadotropin in Urine and of Reagents for the Slide Immunologic Test for Pregnancy Get access Thomas A. Noto, M.D., Thomas A. Noto, M.D. Department of Pathology, University of Miami School of Medicine, and the Clinical Pathology Laboratories, Jackson Memorial Hospital, Miami, Florida Search for other works by this author on: Oxford Academic Google Scholar John B. Miale, M.D. John B. Miale, M.D. Department of Pathology, University of Miami School of Medicine, and the Clinical Pathology Laboratories, Jackson Memorial Hospital, Miami, Florida Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 43, Issue 4, 1 April 1965, Pages 311–313, https://doi.org/10.1093/ajcp/43.4.311 Published: 01 April 1965 Article history Received: 17 August 1964 Accepted: 14 January 1965 Published: 01 April 1965
Identification of genes expressed preferentially in the developing peripheral margin of the optic cup (2009)

Specification of the peripheral optic cup by Wnt signaling is critical for formation of the ciliary body/iris. Identification of marker genes for this region during development provides a starting point for functional analyses. During transcriptional profiling of single cells from the developing eye, two cells were identified that expressed genes not found in most other single cell profiles. In situ hybridizations demonstrated that many of these genes were expressed in the peripheral optic cup in both early mouse and chicken development, and in the ciliary body/iris at subsequent developmental stages. These analyses indicate that the two cells probably originated from the developing ciliary body/iris. Changes in expression of these genes were assayed in embryonic chicken retinas when canonical Wnt signaling was ectopically activated by CA-beta-catenin. Twelve ciliary body/iris genes were identified as upregulated following induction, suggesting they are excellent candidates for downstream effectors of Wnt signaling in the optic cup.