gebhart/patrepeval huggingface dataset:
Evidence of the preferential involvement of .mu.-receptors in analgesia using enkephalins highly selective for peripheral .mu. or .delta. receptors (1981)

In order to study the preferential involvement of mu or delta receptors in the analgesic effects of enkephalins, several peptides which selectively interact with these two kinds of receptors in peripheral organs were synthesized. The inhibitory potency on the electrically stimulated mouse vas deferens (delta receptors) of the short peptide Tyr-D-Ala-Gly-NH-CH(CH3)CH2CH(CH3)2 (6) is 2100 times lower (IC50 = 1220 nM) than that of the longer and more hydrophilic peptide Tyr-D-Ser-Gly-Phe-Leu-Thr (10) (IC50 = 0.58 nM). In contrast, the IC50 values of all the synthesized compounds on the guinea pig ileum assay (mu receptors) are in the same range (100-360 nM). Likewise, their analgesic activities in mice, measured on the hot-plate test after intracerebroventricular injection, are similar. Therefore, the dissociation between antinociceptive properties in mice and potencies on the mouse vas deferens unambiguously reflects a preferential implication of mu receptors in analgesia. The possible involvement of brain delta receptors in behavioral effects is discussed.
Nanostructured Materials (1997)

Chemical strategies for parallel preparation of nanocrystal based single electron devices and nanocrystal-patterned substrates are presented. The Langmuir-Blodgett technique is used for the preparation of ordered particle monolayers, which are incorporated in solid state capacitance devices. Single electron charging is observed in those devices. Patterned thin nanocrystal films are produced by spatially resolved photochemical activation of self-assembled organic monolayers. This method is used to form both metal and semiconductor nanocrystal patterns by binding them to exposed amine groups on the surface.
Radiosurgery alone for solitary and multiple brain metastasis (2006)

1541 Background: Whole-brain radiation (WBRT) in the management of brain metastases treated with radiosurgery (RS) is controversial. Methods: Ninety-eight patients were treated for brain metastases with RS at Johns Hopkins between 4/03 and 7/05. Twenty-eight patients received RS alone after failing WBRT, 33 received RS alone for initial metastases and 37 received RS along with WBRT. Forty-five patients were women and 53 were men, with a median age of 56 (range, 18–92). Histology was: non-small cell lung cancer - 35, breast -14, melanoma -10, renal cell carcinoma - 9, and other - 30. Ninety-two (94%) pts had a KPS of ≥ 70 (median 80). The median number of metastases was 2 (range, 1–14). Results: Follow-up data from date of RS was available for 96 patients. Among those who received RS along with planned WBRT, median survival (MS) was 6.6 months with 1-yr overall survival (OS) 38%. Among patients treated initially with RS alone, MS was 9.7 months with 1-yr OS 42%. Among patients treated with RS for recurrent metastases after prior WBRT, MS was 6.8 months with 1-yr OS 24%. There were no significant differences in survival amongst these 3 treatment groups (p=0.73, log-rank test). For patients with 1–3 metastases (n=66), 1-yr OS was 38% versus 32% for those with ≥ 4 (n=32). Median survivals were 8.4 and 6.7 months, respectively (p=NS). Of patients treated with RS for recurrence, 7 of 25 (28%) with available follow-up data developed recurrent or new metastases whereas 11/27 (41%) treated with RS and planned WBRT and 15/27 (56%) who had RS alone as initial treatment had documented recurrent or new metastases. Conclusions: RS alone may be an effective treatment that preserves survival for those with single or multiple brain metastases at initial presentation or recurrence, but the tradeoff between the marginal increase in risk of brain recurrence versus toxicity and time commitment for WBRT needs further evaluation. The ongoing US Intergroup randomized trial, N0572/Z300, will address some of these questions. No significant financial relationships to disclose.
Resonant enhancement of the electron-energy-loss cross section due to excitation of surface plasmons (1989)

The intensity of the electron-energy loss from vibrational modes of hydrocarbons adsorbed on aluminum and indium was measured as a function of the primary-beam energy in the range 6--13 eV. We have found a resonance in the vibrational-excitation cross section at an energy about 0.5 eV below the energy of the substrate-metal surface plasmon. A model is proposed, in which resonant excitation of a surface plasmon, followed by trapping of the primary electron in an image-dipole induced surface state, takes place in the intermediate stage of the total excitation process. The excitation of the vibrational mode in this intermediate stage occurs either by the electron or by the excited surface plasmon. The results of our model calculation agree quite well with experiment.
Experimental Study of SiO<sub>2</sub>Soot Deposition using the Outside Vapor Deposition Method (2010)

The deposition of pure silica layers using the Outside Vapor Deposition method has been studied. The experimental study focuses on some fabrication parameters that have to be adjusted in order to work with a target temperature optimized for deposition of pure silica compatible with large volume deposition and post-treatments. It is experimentally shown that the optimized soot porous preforms are constituted by homogeneous silica spherical particles of 100 to 110 nm in diameter and have, in this case, densities approximately equal to 0.35 g.cm –3 .
Metathetic polymerization of 1,3,5,7-cyclooctatetraene - a new approach to the synthesis of polyacetylene (1987)

In recent years, there has been considerable interest in polyconjugated polymers which are used in the development of new photoconducting and electroconducting materials. The authors propose a new approach for the synthesis of polyacetylene by the polymerization of 1,3,5,7-cyclooctatetraene on metathesis catalysts. The authors tested various catalytic systems containing tungsten, molybdenum, and chromium. Chromium naphthenate catalysts did not display catalytic activity. The use of tungsten chloride and molybdenum chloride as Ziegler catalyst components gives insoluble polyacetylene powders ranging from brown to black. The system containing WCl/sub 6-n/(OCH(CH/sub 2/Cl)/sub 2/)/sub n/ (where n = 2-3) in combination with diethylaluminum chloride proved to be most active. However, the yield of insoluble polyacetylene in this case was virtually independent of the polymerization conditions and did not exceed a few percent. A much greater yield was obtained by condensing 1,3,5,7-cyclooctatetraene from the gas phase on a solid layer of a catalytic complex previously formed on the walls of the glass reactor or into a concentrated solution of the catalyst.
Products of the fos and jun proto-oncogenes bind cooperatively to the AP1 DNA recognition sequence. (1990)

The products of the proto-oncogenes c-fos and c-jun form a tight protein complex that is a major component of the transcription factor AP1. To analyze the role of fos in the binding of this complex to the AP1 DNA recognition sequence and the mechanism of interaction in further detail, we have expressed a fos protein in E. coli using an expression vector containing the temperature-inducible lambda PL promoter and a synthetic translational start codon. The fos protein encoded by this construct (termed Baf) was enriched by biochemical purification techniques and was found to form a specific complex with c-jun obtained by in vitro transcription/translation. As shown in gel retardation assays, the baf/jun complex binds to the AP1 DNA recognition sequence with high affinity, while no significant binding was observed with either of the individual protein components, indicating cooperative DNA binding of the two proteins. The fact that the bacterial baf protein does not undergo glycosylation indicates that the post-translational modification of eukaryotic c-fos with N-acetylglucosamine is not required for the formation of a stable fos/jun/DNA complex.
Polarization switching and mixing with non-Lagrangian nonlinearity in birefringent Kerr-like and photorefractive media (1991)

Although the theory and practice of optical wave mixing mediated energy and polarization exchanges in nonlinear optical media appear to have been standardized for many years, new principles and phenomena continue to emerge as the underlying nonlinear interactions. The material properties are reexamined. In this paper, we present a detailed theoretical analysis bused on experimentally obtained material parameters of polarization switching and beam amplification in two general classes of nonlinear materials.
Session details: Special poster session 1: processing data streams from body sensor networks (2010)

No abstract available.
Raman spectroscopy and imaging of hemes in healthy and diseased live red blood cells (2004)

Abstract: This work describes how micro Raman spectroscopy and imaging can be applied to functional red blood cells to monitor and understand chemical processes in the living cell. It provides insights into heme aggregation and denaturation and the electronic structure of the malarial pigment haemozoin.
Nuclear maturation of follicle‐enclosed rat oocytes during inhibition of steriodogenesis (1983)

Abstract This study examined the possible role of steriods in meiotic maturation of preovulatory oocytes. Follicles were isolated from PMSG‐treated immature rats and incubated with or withour LH in the presence of one of four inhibitors of steroidogenesis. The inhibitors employed had different sites of attack in the steriodogenic pathway and were aminoglutethimide, cyanoketone, SU 10603 (17β‐hydroxylase inhibitor), and 4‐OH‐androstenedione (aromatase inhibitor). As predicted, the inhibitors drastically altered the pattern of steroid production. None of the inhibitors, however, changed the proportion of oocytes resuming or completing meiosis in response to LH, and there was also no effect of the inhibitors on the oocytes in the absence of LH. It was concluded that steriods are not required for preovulatory nuclear maturation of oocytes in the rat.
Justifying neurorehabilitation (1999)

Neurorehabilitation is evolvingrapidly in our changing health care environment. Neurologists provide principal care to patients with chronic nervous system impairment. Neurologic management is not limited to diagnosis and prevention. Neurologists use rehabilitation strategies to limit medical complications and enhance functional and physiologic recovery.

With the advent of managed care, there is escalating pressure to document both treatment efficacy and efficiency. Fortunately, this pressure converges with our motivation to understand the scientific basis of neurorehabilitation. For divergent reasons we are moving in the right direction.

MS is a prototypical illness that is managed by neurologists in both the acute and chronic setting. Although immunosuppressive therapy holds promise to slow CNS demyelination, most MS patients continue to have progressive limitation of activity. The MS complications treated in the rehabilitation setting include paralysis, spasticity, cognitive impairment, movement disorders, visual disturbances, pain, affective disorders, and autonomic dysfunction.

Neurorehabilitation targets these disease manifestations to help patients maintain greater and more long-lasting independence. Inpatient rehabilitation offers a structured “package” of intensive services. MS patients are usually referred for rehabilitation after functional decline related to disease activity, trauma, surgery, or systemic illness. Inpatient rehabilitation typically follows either acute inpatient …
Effect of Temperature and Crack Tip Velocity on the Crack Growth in Functionally Graded Materials (2011)

The stress-fields near the crack tip for mixed-mode thermo-mechanical loading in functionally graded material (FGM) are developed using displacement potentials in conjugation with an asymptotic approach. The shear modulus, mass density and coefficient of thermal expansion of the FGM are assumed to vary exponentially along the gradation direction. Using insulated crack face boundary condition and steady state heat conduction assumption, the temperature field near to the crack tip is developed. By incorporating the developed temperature field equations with the displacement potentials, asymptotic thermo-mechanical stress field equations are derived. Finally, utilizing the minimum strain energy density criterion and the maximum circumferential stress criterion, the crack growth direction for various crack-tip speeds, non-homogeneity coefficients and temperature fields are determined.
Enantioselective Addition of Vinylzinc Reagents to 3,4-Dihydroisoquinoline <i>N</i>-Oxide (2006)

Ligand 2a promotes the enantioselective addition of vinylzinc reagents to 3,4-dihydroisoquinoline N-oxide to yield chiral allylic hydroxylamines. With 0.1 equiv of the ligand, the product is obtained in up to 84% ee, whereas with 1.2 equiv of the ligand, the ee is increased to the 90-95% range with a variety of aliphatic, cyclic, and aromatic vinylzinc reagents. This method was used to synthesize the protected unnatural amino acid N-Cbz-d-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid in three steps from the allylic hydroxylamine.
IMMUNIZATION OF BURROS WITH LIVING VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS1 (1962)

Journal Article IMMUNIZATION OF BURROS WITH LIVING VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS Get access W. S. GOCHENOUR, JR., W. S. GOCHENOUR, JR. Search for other works by this author on: Oxford Academic PubMed Google Scholar T. O. BERGE, T. O. BERGE 2Present address: Armed Forces Institute of PathologyWashington, D. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar C. A. GLEISER, C. A. GLEISER 3Present address: Army Language School, Officer Student Detachment, Presidio of MontereyCalifornia. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. D. TIGERTT W. D. TIGERTT 4Present address: Walter Reed Army Institute of ResearchWashington, D. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 75, Issue 3, May 1962, Pages 351–362, https://doi.org/10.1093/oxfordjournals.aje.a120257 Published: 01 May 1962 Article history Received: 24 January 1962 Published: 01 May 1962
ChemInform Abstract: “Doping‐Effect” of Lithium Perchlorate in Acid‐Catalyzed Opening of Thiiranes and Thietanes. Formation of 1,4‐Dithianes and Mercaptoalkylperchlorates. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thoracic Endograft for Abdominal Aortic Aneurysms, an Unusual Application for Severe Neck Angulation: Case Report and Literature Review (2010)

Our goal was to achieve complete proximal sealing in severe aortic neck angulation (SNA) during endovascular aneurysm repair (EVAR) of a patient with an abdominal aortic aneurysm (AAA) unfit for surgery. An 82-year-old patient with an infrarenal AAA of 9.8 cm with an SNA of 90 degrees was admitted for acute coronary syndrome. Following coronary treatment, the patient was considered unfit for surgery and therefore was evaluated for EVAR. Aneurysm sac exclusion was obtained with the deployment of a Powerlink bifurcated graft (Endologix Inc, Irvine, CA) inside a Relay thoracic endograft (Bolton Medical, Florida) placed just below the most distal renal artery. At 6 months, computed tomographic angiography confirmed correct graft placement, complete aneurysm exclusion, and a reduction in the aneurysmal sac. In AAA patients with an SNA at high risk of EVAR failure, the adaptability of a thoracic endograft could be considered for proximal sealing.
New Developments in Epoxide Wash-Wear Finishes for Cotton (1960)

A study has been made of a number of epoxides of potential and current utility for the treatment of cotton to produce crease recovery and wash-and-wear properties. The prop erties imparted to cotton by these products vary greatly with respect to the color of the fabric, the retention of strength for a given level of crease recovery, the rate of hydrolysis of the epoxide in the treating bath, etc. It is in fact unreasonable to consider all epoxides as a class. since they differ as much from one another as they do from the conventional nitrogen-containing finishes. In general, however, they demonstrate resistance to chlorine retention and a high level of durability to all types of laundering, including that used by commercial launclries. One of the most promising epoxides examined was vinylcyclohexene dioxide, which imparted a desirable combination of properties to cotton when used alone or in 2: 1 blends with most commercially used nitrogenous resins. Some treatments of cotton were performed with 1,1,3-tris-(2,3-epoxypropoxy)-hutane, This tri-epoxide contains an acid-labile acetal linkage, which can be readily hydrolyzed. The properties of cotton treated with this epoxide were examined before and after hy drolysis. and provided confirmatory evidence for the important role of cross-linking in improving the properties of cellulose with resin treatments.
Cathepsin K – a marker of macrophage differentiation? (2001)

Cathepsin K is a cysteine protease with high matrix-degrading activity. Initially, cathepsin K was described as being expressed exclusively by osteoclasts. It was suggested that cathepsin K expression is a specific feature of cells involved in bone remodelling. The aim of this study was to investigate the hypothesis that cathepsin K is expressed not only in bone-resorbing macrophages, but also more generally in specifically differentiated macrophages, such as epithelioid cells and multinucleated giant cells in soft tissues. Specimens obtained from different organs and anatomical locations of patients suffering from sarcoidosis, tuberculosis, granulomas caused by foreign materials, and sarcoid-like lesions were investigated for the expression of cathepsins B, K, and L. Immunohistochemistry and in situ hybridization showed cathepsin K in epithelioid cells and multinucleated giant cells irrespective of the pathological condition and anatomical location, but not in normal resident macrophages. By immunoelectron microscopy, cathepsin K was discovered in cytoplasmic granules of multinucleated giant cells. In contrast, cathepsin B and cathepsin L were expressed ubiquitously in CD68-positive tissue macrophages, epithelioid cells, and multinucleated giant cells. The results demonstrate that cathepsin K, but not cathepsin B or cathepsin L, differentiates specific phenotypes of macrophages independently of the anatomical site. Its enzymatic characteristics, particularly its high matrix-degrading activity, suggest that cathepsin K-positive epithelioid cells and multinucleated giant cells are characterized by an enhanced specific proteolytic capability. Copyright © 2001 John Wiley & Sons, Ltd.
Theoretical Considerations on Lateral Spread of Implanted Ions (1972)

This paper presents a theoretical analysis on the lateral spread of the distribution for implanted ions in amorphous targets. First, it is shown that the solutions of the second order differential equations concerning moments of the ranges are necessary and sufficient to estimate the lateral distribution, if the Gaussian distribution is assumed. The calculated results of <Rp>, <ΔRp> and the lateral spread are presented. Next, it is shown that the actual distribution function along the lateral direction is approximately expressed by the complementary error function at the window edge, in case when ions are implanted through the mask-window. The variation of the lateral spread with incident ion mass is also calculated. From these calculations, it is concluded that the lateral spread can not be neglected in the case of light ions such as B+ incident to Si.
GENETIC DETERMINANTS OF HYPOXIA-INDUCED CONGENITAL ANOMALIES (1953)

Journal Article GENETIC DETERMINANTS OF HYPOXIA-INDUCED CONGENITAL ANOMALIES Get access THEODORE H. INGALLS, THEODORE H. INGALLS *Department of Epidemiology, Harvard University School of Public HealthBoston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar FREDERICK R. AVIS, FREDERICK R. AVIS *Department of Epidemiology, Harvard University School of Public HealthBoston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar FRANCIS J. CURLEY, FRANCIS J. CURLEY *Department of Epidemiology, Harvard University School of Public HealthBoston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar HOWARD M. TEMIN HOWARD M. TEMIN *Department of Epidemiology, Harvard University School of Public HealthBoston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 44, Issue 5, September 1953, Pages 185–194, https://doi.org/10.1093/oxfordjournals.jhered.a106390 Published: 01 September 1953 Article history Received: 06 July 1953 Published: 01 September 1953
TOTAL SYNTHESIS OF d,l-LONGIFOLENE (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTOTAL SYNTHESIS OF d,l-LONGIFOLENEE. J. Corey, Masaji Ohno, Paul A. Vatakencherry, and Rajat B. MitraCite this: J. Am. Chem. Soc. 1961, 83, 5, 1251–1253Publication Date (Print):March 1, 1961Publication History Published online1 May 2002Published inissue 1 March 1961https://pubs.acs.org/doi/10.1021/ja01466a056https://doi.org/10.1021/ja01466a056research-articleACS PublicationsRequest reuse permissionsArticle Views3199Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantum gate operation of exciton qubits in semiconductor quantum dots (2003)

Potential application of elementary excitation in semiconductor quantum dot to quantum computation is discussed. Construction of scalable hardware and all optical implementation of logical gate that exploits discrete nature of electron-hole states and their well concentrated oscillator strenth for ultrafast gate operation are proposed. Rabi population oscillation of an excitonic two-level system in an isolated single InxGa1-xAs quantum dot is manifested by a quantum wave function interferometry in time domain, demonstrating a long lived coherence of zero-dimensional excitonic states and revealed the coherent population flopping under strong optical field. A phase-sensitive coherent gate operation on single-dot exciton qubit is demonstrated.
Studies on the identification of genetic risk for heritable colon cancer. (1985)

The limitations of the assignment of genetic risk status for colon cancer based on pedigree data are known. The purpose of this paper is to present two approaches being evaluated for the identification of genetic predisposition for colon cancer: in vivo studies on colonic mucosa and in vitro studies on dermal fibroblasts derived from high- and low-risk individuals.