gebhart/patrepeval huggingface dataset:
Seeing the Future of Cancer-Associated Transcription Factor Drug Targets (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of underlayers on the soft properties of high magnetization FeCo films (2003)

A remarkable reduction in coercivity Hc was found in sputtered Fe65Co35(=FeCo) films on Cu, NiFe, Ru, Ta/Cu, Ta/NiFe, or Cu/IrMn underlayers. A decrease in Hc from 120 to 7–12 Oe was observed for Cu, NiFe, and Ru underlayers as thin as 2.5 nm but less for Ta. A Cu underlayer significantly reduced the maximum anisotropy fields from 2 kOe to 40 Oe, resulting in a well-defined in-plane average uniaxial anisotropy field Hk∼30 Oe. The saturation magnetostriction with Cu was (47±4)×10−6, independent of Cu and FeCo thicknesses. In-plane tensile film stress decreased with underlayer thickness tUL from 2 to 0.2 GPa but much less rapidly than the reduction in Hc. All underlayers induced a (110) texture in FeCo, which was strongest with Ta. Transmission electron microscopy of cross-sections showed an unusually long range coherence with low angle grain boundaries in the FeCo without an underlayer. Clear columnar grains were visible with all underlayers with an average grain size of ∼50 nm with Ta dropping to 9–10 nm for Cu, NiFe, and Ru. This alone is sufficient to explain quantitatively the reduction in Hc using Hoffmann’s ripple theory.
Wind energy and wildlife research at the Forest and Rangeland Ecosystem Science Center (2011)

The United States has embarked on a goal to increase electricity generation from clean, renewable sources by 2012. Towards this end, wind energy is emerging as a widely distributed form of renewable energy throughout the country. The national goal is for energy from wind to supply 20 percent of the country's electricity by 2030. As with many land uses, trade-offs exist between costs and benefits. New wind developments are occurring rapidly in parts of the United States, often leaving little time for evaluation of potential site-specific effects. These developments are known to affect wildlife, directly from fatality due to collision with the infrastructure and indirectly from loss of habitat and migration routes. The Department of the Interior, in particular, is challenged to balance energy development on public lands and also to conserve fish and wildlife. The Secretary of the Interior has proposed a number of initiatives to encourage responsible development of renewable energy. These initiatives are especially important in the western United States where large amounts of land are being developed or evaluated for wind farms.
Spectroscopy of higher harmonics in dynamic atomic force microscopy (2003)

Dynamic atomic force microscopy (AFM) is a standard technique for imaging and the analysis of surfaces at the nanometre scale. In order to estimate material properties from the microscope data it is important to understand the nonlinear dynamics in the tip–sample interaction. Here, the system response of a tapping-mode atomic force microscope is investigated with numerical simulations. In the numerical model, the AFM cantilever is treated as a distributed parameter system that is capable of higher eigenmode excitation. With this multiple-degree-of-freedom (MDOF) approach the generation of higher harmonics as well as the generation of subharmonics is analysed. Under typical imaging conditions higher harmonics are generated whereas a closer approach to the specimen surface can lead to a complicated dynamics.
Factors related to childbirth satisfaction (2004)

Personal control during childbirth was an important factor related to the women's satisfaction with the childbirth experience. Helping women to increase their personal control during labour and birth may increase the women's childbirth satisfaction.
PHARMACOLOGICAL ACTIONS OF BERBERINE ON THE CENTRAL NERVOUS SYSTEM (1970)

The alkaloid, berberine is widely distributed in the vegetable kingdom. The berberine containing plants are largely used in indigenous medicine. A crude extract known as “Rasaut, Rasvanti and Rasanjana” is a widely used household remedy as a stomachic, bitter tonic and diaphoretic. There is a renewed interest in berberine because of its reported usefulness in diarrhoeas (1) cholera (2) and experimental amoebiasis (3, 4). Some of our studies on the actions of berberine on the central nervous system are presented in this paper.
Oxidative Stress Impairs Skeletal Muscle Repair in Diabetic Rats (2004)

Alongside increased proteolysis, the inability to repair damaged skeletal muscle is a characteristic feature of uncontrolled diabetes. This study evaluates the role of oxidative stress in muscle-specific gene regulatory regions and myosin chain synthesis in streptozotocin (STZ)-induced diabetic and ZDF rats. In the gastrocnemius muscle of diabetic rats, prooxidant compounds were seen to increase while antioxidant levels fell. Myogenic regulatory factors--Myo, myogenin, and Jun D--were also reduced, and muscle enhancer factor (MEF)-1 DNA binding activity was impaired. Moreover, synthesis of muscle creatine kinase and both heavy and light chains of myosin were impaired, suggesting that oxidative stress triggers the cascade of events that leads to impaired muscle repair. Dehydroepiandrosterone has been reported to possess antioxidant properties. When it was administered to diabetic rats, in addition to an improved oxidative imbalance there was a recovery of myogenic factors, MEF-1 DNA binding activity, synthesis of muscle creatine kinase, and myosin light and heavy chains. Vitamin E administration to STZ-induced diabetic rats reverses oxidative imbalance and improves muscle gene transcription, reinforcing the suggestion that oxidative stress may play a role in diabetes-related impaired muscle repair.
IR50 - an Early-Maturing, Fine-Grained Rice for Kar Season (1984)

This article 'IR50 - an Early-Maturing, Fine-Grained Rice for Kar Season' appeared in the International Rice Research Newsletter series, created by the International Rice Research Institute (IRRI). The primary objective of this publication was to expedite communication among scientists concerned with the development of improved technology for rice and for rice based cropping systems. This publication will report what scientists are doing to increase the production of rice in as much as this crop feeds the most densely populated and land scarce nations in the world.
Acoustic storage and processing device using <i>p</i>-<i>n</i> diodes (1975)

Storage experiments and signal-processing techniques with surface acoustic Rayleigh waves in a p-n diode array close to a YZ LiNbO3 substrate are described. A storage time of 15 sec for a writing time constant of 1 μsec has been measured.
Nuchal translucency in multiple pregnancies. (2000)

Increased NT in multiple pregnancies indicates fetuses at risk of chromosomal abnormalities and fetal malformation, and monochorionic twin pregnancies at higher risk of adverse outcome.
The Use of Aldosterone-Renin Ratio as a Diagnostic Test for Primary Hyperaldosteronism and Its Test Characteristics under Different Conditions of Blood Sampling (2005)

Recent reviews recommended the use of the aldosterone/renin ratio (ARR) to screen for primary hyperaldosteronism. However, widely different cutoff levels have been proposed, and test characteristics of ARR under different conditions of sampling are not known. We conducted a retrospective review among 45 subjects with carefully validated diagnoses of primary hyperaldosteronism and 17 subjects with essential hypertension to study the utility of ARR. Sixty-two patients with 75 sets of plasma renin activity (PRA), aldosterone, and ARR values from a postural study and 48 sets of values from a saline suppression test were analyzed. Ninety-four percent of these subjects underwent investigations because of hypokalemic hypertension.ARR yielded larger areas under the curve in the receiver-operating-characteristics curve than PRA or aldosterone under all conditions of testing. Our results confirmed the superiority of ARR to either aldosterone or PRA alone as a diagnostic test for primary hyperaldosteronism.ARR cutoff levels were significantly affected by the condition of testing. Depending on posture and time of day, it varied from 13.1-35.0 ng/dl per ng/ml.h in our study population. When using ARR for screening primary hyperaldosteronism, posture and time of sampling should be standardized both within and between centers to minimize variability in cutoff levels.
Iron, neuroinflammation, and Alzheimer's disease (2005)

The present article reviews the roles and interactions of iron and neuroinflammation in Alzheimer's disease. It highlights the importance of neuroinflammatory changes in the glial scar after neuronal injury, in promoting iron accumulation, and iron-dependent oxidative damage. Elevation of iron in Alzheimer's disease not only affects amyloid precursor protein processing and mitochondrial function but also induces the aggregation of Abeta peptide and abnormalities in signal transduction processes associated with oxidative damage. Collective evidence suggests that although alterations in iron homeostasis may not be the primary triggering event that starts the pathological cascade of Alzheimer's disease, it is an important factor involved in neuroinflammation and progression of this disease.
A precision CTD microprofiler (1974)

This paper describes a conductivity-temperature-depth (CTD) system designed for precise fine scale measurements of salinity and temperature in the deep ocean. The conductivity sensor is a miniature (8 mm long, 2 mm I.D.) four electrode cell. Temperature is sensed with a combination of a miniature fast thermistor (30 ms) and a platinum resistance thermometer. The combined outputs of the thermistor and the platinum thermometer, with their respective interface circuits, have the excellent long term stability and linearity of the platinum thermometer and the speed of the thermistor but are unaffected by thermistor calibration drift. Pressure is measured using a strain gage bridge transducer. All three sensors with their respective interface circuits and the 16 bit digitizer are excited with 10 KHz sine waves. The D/A converter in the digitizer is an electronically switched binary ratio transformer having negligible errors. The digitizer uses successive approximation to measure the 10 KHz sensor output to input voltage ratio. Digitization time is 10 milliseconds, thus, a complete scan of all three sensors is made in 30 milliseconds. The digital output of each scan is transmitted via armoured cable to the shipboard unit in "TELETYPE" format using frequency-shift-key (FSK) modulation. The shipboard unit demodulates the FSK signal from the sensor unit and provides both serial and parallel digital outputs to a shipboard computer. Digital displays and analog outputs are also provided by the deck unit.
A Quantitative Solutions and Approaches for Mutual Coupling Reduction in MIMO Antenna (2015)

In this paper, various systematic approaches for design of MIMO (Multiple-Input-Multiple-Output) antenna with negligible mutual coupling has been proposed. The basic single element antenna with multiband operating behavior has been simulated for the total geometry of 55X55 mm2. Multi-antenna configurations with optimum geometry has been then carried out by considering the basic triple band antenna with best isolations between them. Various 2X2 MIMO antenna configurations are simulated with improved excitation isolations are presented. In this article, 2X2 MIMO antenna with triple band operations on a common substrate has been proposed in a MOM based CADFEKO EM-Simulation software. Performance parameter of each MIMO configuration against MC has carried out for 2-element antenna systems yielding highest isolation of-41 dB.
Salvage of Infected Expander Prostheses in Breast Reconstruction (2003)

Periprosthetic infection is a devastating complication following breast reconstruction with prostheses. Traditional surgical principles dictate removal of the prosthesis to control infection. Although successful salvage of prostheses in the presence of periprosthetic infections has been reported in the plastic and other surgical literature, salvage procedures remain seldom practiced. Reports in the plastic surgery literature have been limited to implant salvage following cosmetic breast augmentation and subcutaneous mastectomy with implants. Salvage of saline-filled expander prostheses used in breast reconstruction following mastectomy for cancer has not been previously reported. The authors review their experience with implant salvage in patients with periprosthetic infections following breast reconstruction for a 6-year period. Fourteen patients (13 with saline-filled expander prostheses and one with silicone prosthesis) underwent implant salvage. Salvage of the breast reconstruction was successful in nine patients. Staphylococcus aureus infection was associated with poorer salvage rate (p = 0.023). Previous radiotherapy to the chest wall did not affect the salvage outcome (p = 0.50). In selected patients, immediate salvage of a breast reconstruction in the presence of prosthesis-related infection remains an alternative to implant removal followed by delayed reconstruction.
Bioelectrical Impedance Assessment of Wound Healing (2012)

Objective assessment of wound healing is fundamental to evaluate therapeutic and nutritional interventions and to identify complications. Despite availability of many techniques to monitor wounds, there is a need for a safe, practical, accurate, and effective method. A new method is localized bioelectrical impedance analysis (BIA) that noninvasively provides information describing cellular changes that occur during healing and signal complications to wound healing. This article describes the theory and application of localized BIA and provides examples of its use among patients with lower leg wounds. This promising method may afford clinicians a novel technique for routine monitoring of interventions and surveillance of wounds.
Neglected evidence in idiopathic pulmonary fibrosis: from history to earlier diagnosis (2013)

This perspective highlights some evidence that has hitherto been neglected, especially because it may not have been sufficiently explicated in the clinical respiratory medicine literature. Idiopathic pulmonary fibrosis (IPF) has appeared only in the second half of the 20th century and, like lung cancer and chronic obstructive pulmonary disease, may be a direct consequence of the cigarette smoking epidemic. It is a disease of lung ageing, with most affected patients being >70 years of age. The relationship between lung ageing and pulmonary fibrosis is further illustrated in the bleomycin mouse model, in which older males develop more fibrosis than young female mice. Earlier diagnosis of IPF is a prerequisite for significant progress to be made in the long-term outcome and prognosis. We consider that only two different yet complementary and realistic approaches could lead to earlier diagnosis of IPF and possibly to allowing more efficient disease management: 1) investigating any patients with early Velcro crackles at lung auscultation through proactive education of, and commitment from, primary care physicians; and 2) using current large-scale lung cancer screening strategies with low-dose high-resolution computed tomography in smokers for the detection of subclinical interstitial lung disease and especially early IPF.
<title>GC-based dynamic QoS priority handoff scheme in multimedia cellular systems</title> (2001)

A dynamic call admission control (CAC) and its associated resource reservation (RR) schemes are proposed in this research based on the guard channel (GC) concept for a wireless cellular system supporting multiple QoS classes. A comprehensive service model is developed, which includes not only mobile terminals' bandwidth requirements but also their different levels of priorities, rate adaptivity and mobility. The proposed CAC policy selects the resource access thresold according to the estimated number of incoming call requests of different QoS classes. The amount of resources to be reserved is dynamically adjusted by considering neighboring-cell higher-priority calls which are likely to handoff. The handoff interaction between adjacent cells is estimated by using radio propagation in terms of the signal-to-noise ratio (SNR) and the distance of each active call in neighboring cells. Experiments are conducted by using the OPNET simulator to study the performance of the proposed scheme under various traffic conditions. It is shown that better QoS guarantees can be provided by the proposed CAC and RR schemes.
Degradation of the insecticide SD 8280, 2‐chloro‐1‐(2, 4‐dichlorophenyl)vinyl dimethyl phosphate, in soils (1976)

Abstract The degradation of the insecticide SD 8280 [2‐chloro‐1‐(2,4‐dichlorophenyl)vinyl dimethyl phosphate] in soil has been examined under laboratory conditions using two soils from rice‐growing areas in Japan and one UK soil. In all soils SD 8280 underwent degradation to 1‐(2,4‐dichlorophenyl)ethanol, 2,4‐dichlorobenzoic acid, 2‐chloro‐1‐(2,4‐dichlorophenyl)vinyl methyl hydrogen phosphate and 2′,4′‐dichloro‐acetophenone. These degradation products were present in the soils as free (extractable) compounds and as bound forms and soil binding occurred most extensively with 2,4‐dichlorobenzoic acid. Polar products were also formed and these appeared to be in part the result of complexing of degradation products with the soil organic matter. The effect on the degradation of the insecticide of varying the moisture content of one soil was also examined. In soil incubated at 11, 17, 30 and 62% moisture the recovery of SD 8280 after 60 days was 71.0, 12.3, 9.0 and 11.3%, respectively. Although the rate of degradation varied, the same degradation products were detected in all samples.
Comparison of culture media for ex vivo cultivation of limbal epithelial progenitor cells. (2013)

PURPOSE: To compare the effectiveness of three culture media for growth, proliferation, differentiation, and viability of ex vivo cultured limbal epithelial progenitor cells. METHODS: Limbal epithelial progenitor cell cultures were established from ten human corneal rims and grew on plastic wells in three culture media: supplemental hormonal epithelial medium (SHEM), keratinocyte serum-free medium (KSFM), and Epilife. The performance of culturing limbal epithelial progenitor cells in each medium was evaluated according to the following parameters: growth area of epithelial migration; immunocytochemistry for adenosine 5′-triphosphate-binding cassette member 2 (ABCG2), p63, Ki67, cytokeratin 3 (CK3), and vimentin (VMT) and real-time reverse transcription polymerase chain reaction (RT–PCR) for CK3, ABCG2, and p63, and cell viability using Hoechst staining. RESULTS: Limbal epithelial progenitor cells cultivated in SHEM showed a tendency to faster migration, compared to KSFM and Epilife. Immunocytochemical analysis showed that proliferated cells in the SHEM had lower expression for markers related to progenitor epithelial cells (ABCG2) and putative progenitor cells (p63), and a higher percentage of positive cells for differentiated epithelium (CK3) when compared to KSFM and Epilife. In PCR analysis, ABCG2 expression was statistically higher for Epilife compared to SHEM. Expression of p63 was statistically higher for Epilife compared to SHEM and KSFM. However, CK3 expression was statistically lower for KSFM compared to SHEM. CONCLUSIONS: Based on our findings, we concluded that cells cultured in KSFM and Epilife media presented a higher percentage of limbal epithelial progenitor cells, compared to SHEM.
Label‐Free Attomolar Detection of Proteins Using Integrated Nanoelectronic and Electrokinetic Devices (2010)

High-sensitivity screening of biomarkers is critical to areas ranging from early disease detection and diagnosis to bioterrorism surveillance. Here the development of integrated nanoelectronic and electrokinetic devices for label-free attomolar detection of proteins is reported. Electrically addressable silicon nanowire field-effect transistors and electrodes for electrokinetic transport are integrated onto a common sensor chip platform, and the nanowire devices are subsequently functionalized with receptors for selective biomarker detection. Nanowire devices modified with monoclonal antibody for prostate specific antigen exhibit close to a 10(4) increase in sensitivity due to streaming dielectrophoresis and corresponding electrostatic contribution to the binding affinity after application of an AC electric field. The devices are also modified with receptors for cholera toxin subunit B and achieve a similar enhancement. These results show general applicability of this method, and could open up opportunities in early stage disease detection and the analysis of proteins from single cells.
High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis (2014)

With the goal to generate and characterize the phenotypes of null alleles in all genes within an organism and the recent advances in custom nucleases, genome editing limitations have moved from mutation generation to mutation detection. We previously demonstrated that High Resolution Melting (HRM) analysis is a rapid and efficient means of genotyping known zebrafish mutants. Here we establish optimized conditions for HRM based detection of novel mutant alleles. Using these conditions, we demonstrate that HRM is highly efficient at mutation detection across multiple genome editing platforms (ZFNs, TALENs, and CRISPRs); we observed nuclease generated HRM positive targeting in 1 of 6 (16%) open pool derived ZFNs, 14 of 23 (60%) TALENs, and 58 of 77 (75%) CRISPR nucleases. Successful targeting, based on HRM of G0 embryos correlates well with successful germline transmission (46 of 47 nucleases); yet, surprisingly mutations in the somatic tail DNA weakly correlate with mutations in the germline F1 progeny DNA. This suggests that analysis of G0 tail DNA is a good indicator of the efficiency of the nuclease, but not necessarily a good indicator of germline alleles that will be present in the F1s. However, we demonstrate that small amplicon HRM curve profiles of F1 progeny DNA can be used to differentiate between specific mutant alleles, facilitating rare allele identification and isolation; and that HRM is a powerful technique for screening possible off-target mutations that may be generated by the nucleases. Our data suggest that micro-homology based alternative NHEJ repair is primarily utilized in the generation of CRISPR mutant alleles and allows us to predict likelihood of generating a null allele. Lastly, we demonstrate that HRM can be used to quickly distinguish genotype-phenotype correlations within F1 embryos derived from G0 intercrosses. Together these data indicate that custom nucleases, in conjunction with the ease and speed of HRM, will facilitate future high-throughput mutation generation and analysis needed to establish mutants in all genes of an organism.