gebhart/patrepeval huggingface dataset:
Significance of error‐avoiding mechanisms for oxidative DNA damage in carcinogenesis (2007)

Reactive oxygen species (ROS) are produced through normal cellular metabolism, and their formation is further enhanced by exposure to ionizing radiation and various chemicals. ROS attack DNA, and the resulting oxidative DNA damage is considered to contribute to aging, carcinogenesis and neurodegeneration. Among various types of oxidative DNA damage, 8-oxo-7,8-dihydroguanine (8-oxoguanine or 8-oxoG) is the most abundant, and plays significant roles in mutagenesis because of its ability to pair with adenine as well as cytosine. Enzymatic activities that may be responsible for preventing 8-oxoG-evoked mutations were identified in mammalian cells. We have focused on the following three enzymes: MTH1, OGG1 and MUTYH. MTH1 is a mammalian ortholog of Escherichia coli MutT, which hydrolyzes 8-oxo-dGTP to its monophosphate form in nucleotide pools, thereby preventing incorporation of the mutagenic substrate into DNA. OGG1, a functional counterpart of E. coli MutM, has an 8-oxoG DNA glycosylase activity. MUTYH, a mammalian ortholog of E. coli MutY, excises an adenine paired with 8-oxoG. These three enzymes are thought to prevent mutagenesis caused by 8-oxoG in mammals. To analyze the functions of mammalian MTH1 (Mth1), OGG1 (Ogg1) and MUTYH (Mutyh) in vivo, we established mutant mice for these three enzymes by targeted mutagenesis, and investigated spontaneous tumorigenesis as well as mutagenesis. Here we discuss our recent investigation of mutagenesis and carcinogenesis in these mutant mice.
Test data for the transverse Mercator projection (2009)

This is a set of 287000 geographic points together with their coordinates in the transverse Mercator projection. The WGS84 ellipsoid (equatorial radius <em>a</em> = 6378137 m, flattening <em>f</em> = 1/298.257223563) is used, with central meridian 0°, central scale factor 0.9996 (the UTM value), false easting = false northing = 0 m. Each line of the test set gives 6 space delimited numbers latitude, φ (degrees, exact) longitude, λ (degrees, exact — see below) easting (meters, accurate to 0.1 pm) northing (meters, accurate to 0.1 pm) meridian convergence (degrees, accurate to 10<sup>−18</sup> deg) scale (accurate to 10<sup>−20</sup>) These are computed using high-precision calculations using the exact formulas for the projection, see Lee (1976). The latitude and longitude are all multiples of 10<sup>−12</sup> deg and should be regarded as exact, except that λ = 82.63627282416406551° should be interpreted as exactly (1 − <em>e</em>) 90°, where <em>e</em> is the eccentricity given by <em>e</em><sup>2</sup> = <em>f</em> (2 − <em>f</em> ). The contents of the file are as follows: 250000 entries randomly distributed in φ ∈ [0°, 90°], λ ∈ [0°, 90°] 1000 entries randomly distributed on φ ∈ [0°, 90°], λ = 0° 1000 entries randomly distributed on φ = 0°, λ ∈ [0°, 90°] 1000 entries randomly distributed on φ ∈ [0°, 90°], λ = 90° 1000 entries close to φ = 90° with λ ∈ [0°, 90°] 1000 entries close to φ = 0°, λ = 0° with φ ≥ 0°, λ ≥ 0° 1000 entries close to φ = 0°, λ = 90° with φ ≥ 0°, λ ≤ 90° 2000 entries close to φ = 0°, λ = (1 − <em>e</em>) 90° with φ ≥ 0° 25000 entries randomly distributed in φ ∈ [−89°, 0°], λ ∈ [(1 − <em>e</em>) 90°, 90°] 1000 entries randomly distributed on φ ∈ [−89°, 0°], λ = 90° 1000 entries randomly distributed on φ ∈ [−89°, 0°], λ = (1 − <em>e</em>) 90° 1000 entries close to φ = 0°, λ = 90° (φ < 0°, λ ≤ 90°) 1000 entries close to φ = 0°, λ = (1 − <em>e</em>) 90° (φ < 0°, λ ≤ (1 − <em>e</em>) 90°) The entries for φ < 0° and λ ∈ [(1 − <em>e</em>) 90°, 90°] use the “extended” domain for the transverse Mercator projection explained in Sec. 5 of Karney (2011). The first 258000 entries have φ ≥ 0° and are suitable for testing implementations following the standard convention.
How Biometric Authentication Poses New Challenges to Our Security and Privacy [In the Spotlight] (2017)

Discusses the challenges that face biometric authentication in the areas of privacy and network security. The use of biometric data — an individual’s measurable physical and behavioral characteristics — isn’t new. Government and law enforcement agencies have long used it. The Federal Bureau of Investigation (FBI) has been building a biometric recognition database; the U.S. Department of Homeland Security is sharing its iris and facial recognition of foreigners with the FBI. But the use of biometric data by consumer goods manufacturers for authentication purposes has skyrocketed in recent years. For example, Apple’s iPhone allows users to scan their fingerprints to unlock the device, secure mobile bill records, and authenticate payments. Lenovo and Dell are companies that leverage fingerprints to enable users to sign onto their computers with just a swipe. Using biometric data to access our personal devices is increasing as a way to get around the limitations of the commonly used password-based mechanism: it’s easier, more convenient, and (theoretically) more secure. But biometric data can also be stolen and used in malicious ways. Capturing fingerprints at scale isn’t as easy as lifting a credit card or Social Security number, but experience and history tells us that once something is used extensively, criminals will figure out how to misuse and monetize it.
Investing in Africa (2000)

In this volume, the author examines the constraints to private sector growth in sub-Saharan Africa. She addresses two sets of issues - the constraints of firm-level productivity and the barriers to investment in the private sector. Focusing on the manufacturing sector, Vijaya Ramachandran identifies and analyzes several key problems that are responsible for low productivity and investment levels in Africa. Finally, she outlines policies that may lead to the improvement of productivity and investment levels, and the role of national and international agencies in promoting these strategies.
Lanthanum Dibromide Complexes of Sterically Demanding Aminopyridinato and Amidinate Ligands (2006)

Abstract It is report on synthesis and structure of Ap*LaBr 2 (THF) 3 and Am*LaBr 2 (THF) 3 (Ap*‐H = {(2,6‐diisopropyl‐phenyl)[6‐(2,4,6‐triisopropyl‐phenyl)‐pyridin‐2‐yl]‐amine}, Am*‐H = N,N′‐bis‐(2,6‐diisopropylphenyl)benzamidine). X‐ray crystal structure analyses of the two seven coordinated complexes were carried out to compare the steric demand of the two amido ligands. A similar overall primary coordination site bulkiness for both ligands and distinct differences regarding this bulkiness for different directions were observed. A better shielding of the second coordination sphere was observed for the aminopyridinate.
Mapping of cingulate motor function by cortical stimulation (2013)

An 8-year-old boy with intractable left mesiofrontal lobe epilepsy underwent placement of stereotactic intracerebral depth electrodes to better localise the epileptogenic zone. Co-registration of preoperative MRI and post-electrode implantation CAT allowed for anatomical localisation of electrode contacts. Electrical stimulation of electrodes over the dorsal and ventral banks of the cingulate cortex on the left produced right foot dorsiflexion and right wrist and elbow flexion, respectively, demonstrating detailed representation of cingulate motor function in humans, somatotopically distributed along the banks of the cingulate sulcus, as seen in the non-human primate. [Published with video sequences].
A Stochastic Model of Turbulent Mixing for the Prediction of Burn Rate in a Spark-Ignition Engine (1983)

Abstract A model for predicting the burn rate of a premixed and stratified internal combustion engine is developed. The model involves an ignition period dominated by mslecular and turbulent diffusion and a combustion period dominated by turbulent diffusion. A correlation based on a deterministic model for the structure of turbulence is used. This correlation employs turbulent flow characteristics and the laminar flame speed. A statistical model based on turbulence characteristics which employs a Monte Carlo technique to follow the mixing process is developed to describe the combustion period. This model is used to predict the effects of spark advance, exhaust gas recirculation, and stroke variation on the burn rate of a premixed charge engine with no intake swirl. The effect of mixture stratification is also explored. The model agrees well with the experimental data and predicts the correct trend for the effect of spark advance, exhaust gas recirculation, and stroke variation. With increased mixture stratification, the model predicts a reduction in available work.
Impaired growth and intracranial calcifications in autosomal dominant hypocalcemia caused by a GNA11 mutation (2016)

The identified GNA11 mutation results in biochemical abnormalities typical for ADH. Additional features, including short stature and early intracranial calcifications, cosegregated with the mutation. These findings may indicate a wider role for Gα11 signaling besides calcium regulation.
Integrated Reproduction of Human Motion Components by Motion Copying System (2010)

Currently, the development of leading-edge technology for recording and loading human motion on the basis of haptic information is required in the field of manufacturing and human support. Human movement is an assembly of motion components. Since human movements should be supported by a robot in real time, it is necessary to integrate the morion components, which were saved earlier. Once such motion integration is realized, future technology for use in daily human life is developed.This paper proposes the integrated reproduction of the decomposed components of human motion by using a motion copying system. This system is the key technology for the realization of the acquisition, saving and reproduction of the real-world haptic information. By the proposed method, it is possible not only to achieve expert skill acquisition, skill transfer to robots, and power assist for each motion component but also to open up new areas of applications.
Abrogation of Allogeneic Inhibition by Cortisone (1965)

Tumor cells from homozygous mice grow better upon transplanation to syngeneic mice than to F(1) hybrids between the tumor strain and a foreign strain. The inhibition of cell growth in the hybrids (called allogeneic inhibition), which is detected by tumor transplantation into mice, cotuld be abrogated by treatment of the recipient mice with cortisone acetate. Cortisone also abolished allogeneic inhibition in vitro; abolition was detected by treating tumor cultures with cell extracts containing foreign isoantigens of the H-2 type.
Quantitative Study of the Effects of Thyroxine on Components of the Electron-Transfer System<sup>*</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative Study of the Effects of Thyroxine on Components of the Electron-Transfer System*Daniel N. Moury, Frederick L. Crane, and Carolyn McNeelyCite this: Biochemistry 1964, 3, 8, 1068–1072Publication Date (Print):August 1, 1964Publication History Published online1 May 2002Published inissue 1 August 1964https://pubs.acs.org/doi/10.1021/bi00896a010https://doi.org/10.1021/bi00896a010research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of a doubly-swept blade tip for rotorcraft noise reduction (1992)

A computational study was performed for a doubly-swept rotor blade tip to determine its benefit for high-speed impulsive (HSI) and blade-vortex interaction (BVI) noise. This design consists of aft and forward sweep. For the HSI-noise computations, unsteady Euler calculations were performed for several variations to a rotor blade geometry. A doubly-swept planform was predicted to increase the delocalizing Mach number to 0.94 (representative of a 200+ kt helicopter). For the BVI-noise problem, it had been hypothesized that the doubly-swept blade tip, by producing a leading-edge vortex, would reduce the tip-vortex effect on BVI noise. A procedure was used in which the tip vortex velocity profile computed by a Navier-Stokes solver was used to compute the inflow associated with BVI. This inflow was used by a Euler solver to compute the unsteady pressures for an acoustic analysis. The results of this study were inconclusive due to the difficulty in accurately predicting the viscous tip vortex downstream of the blade. Also, for the condition studied, no leading-edge vortex formed at the tip.
Asks, newts and efts (1931)

Asks, newts and efts Get access J. W. Fawcett J. W. Fawcett 1Satley, Co. Durham Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLXI, Issue aug08, 8 August 1931, Page 103, https://doi.org/10.1093/nq/CLXI.aug08.103b Published: 08 August 1931
Effect of ripening temperature on the quality of low moisture Mozzarella cheese: 1. Composition andproteolysis (2001)

Low-moisture Mozzarella cheese, in duplicate trials, was ripened at 0, 4, 10 or 15 o C for 70 d. For all temperature treatments, increasing ripening time resulted in significant (P < 0.05) increases in the level of proteolysis as measured by the levels of pH 4.6 soluble-N (pH 4.6SN) and 5% phosphotungstic acid-soluble N (PTA-N). Urea-PAGE electrophoretograms of the pH 4.6-insoluble cheese extracts showed that increasing the storage temperature resulted in an increase in the extent of degradation of s1 -CN but had little effect on the degradation of -casein. Increasing the ripening temperature resulted in a significant increase in the mean level of pH 4.6SN and PTA-N over the 70 d ripening period. Reverse-phase HPLC (RP-HPLC) of the pH 4.6-soluble and 70% ethanol-soluble fractions of the pH4.6-soluble cheese extracts indicated a heterogeneous array of peptides. The concentration of early-eluting peptides, representing amino acids and small peptides, increased as the ripening temperature was increased.
A validation study of PD control of a closed-chain mechanical system (2002)

In this paper, we briefly review recent results by the authors on the formulation of the equations of motion of closed-chain mechanisms and the development of PD control strategies with guaranteed Lyapunov asymptotic stability. We then introduce and derive the equations of motion of the Rice Planar Delta Robot which was designed and built at Rice University as a test bed to perform control experiments for closed-chain mechanisms. Finally, we present simulation as well as experimental results to illustrate the successful application of PD plus simple gravity control strategy for this class of dynamical systems.
The response of isoprene emission rate and photosynthetic rate to photon flux and nitrogen supply in aspen and white oak trees (1996)

ABSTRACT Isoprene is the primary biogenic hydrocarbon emitted from temperate deciduous forest ecosystems. The effects of varying photon flux density (PFD) and nitrogen growth regimes on rates of isoprene emission and net photosynthesis in potted aspen and white oak trees are reported. In both aspen and oak trees, whether rates were expressed on a leaf area or dry mass basis, (1) growth at higher PFD resulted in significantly higher rates of isoprene emission, than growth at lower PFD, (2) there is a significant positive relationship between isoprene emission rate and leaf nitrogen concentration in both sun and shade trees, and (3) there is a significant positive correlation between isoprene emission rate and photosynthetic rate in both sun and shade trees. The greater capacity for isoprene emission in sun leaves was due to both higher leaf mass per unit area and differences in the biochemical and/or physiological properties that influence isoprene emission. Positive correlations between isoprene emission rate and leaf nitrogen concentration support the existence of mechanisms that link leaf nitrogen status to isoprene synthase activity. Positive correlations between isoprene emission rate and photosynthesis rate support previous hypotheses that isoprene emission plays a role in protecting photosynthetic mechanisms during stress.
Lymphocyte transformation in response to phytohaemagglutinin in primary biliary cirrhosis: The search for a plasma inhibitory factor (1973)

The aim of this study was to determine the importance of plasma inhibitory factors in producing the impaired phytohaemagglutinin (PHA)-induced lymphocyte transformation that is seen in some patients with primary biliary cirrhosis. Twenty-six normal subjects and 12 patients with primary biliary cirrhosis were studied. The lymphocytes from each subject were cultured in the presence of autologous plasma and also in the presence of homologous plasma from a normal subject or from a patient with primary biliary cirrhosis. The results confirm that a proportion of patients with primary biliary cirrhosis are anergic and that the impaired lymphocyte transformation to PHA in vitro can be partially accounted for by the presence of inhibitory factors in the plasma. However, these factors are unlikely to account completely for the impaired transformation, it being probable that there are also abnormalities of the T lymphocytes themselves.
In‐Hospital Outcomes of Dual Loading Antiplatelet Therapy in Patients 75 Years and Older With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Findings From the CCC‐ACS (Improving Care for Cardiovascular Disease in China‐Acute Coronary Syndrome) Project (2018)

URL: http://www.ClinicalTrials.gov. Unique identifier: NCT02306616.
High vertical yield InP nanowire growth on Si(111) using a thin buffer layer (2013)

We demonstrate the growth of InP nanowires on Si(111) using a thin InP buffer layer. The buffer layer is grown using a two-step procedure. The initial layer formation is ensured by using a very low growth temperature. An extremely high V/III ratio is necessary to prevent In droplet formation at this low temperature. The second layer is grown on the initial layer at a higher temperature and we find that post-growth annealing of the buffer layer does not improve its crystal quality significantly. It is found that the layers inherently have the (111)B polarity. Nanowires grown on this buffer layer have the same morphology and optical properties as nanowires grown on InP (111)B substrates. The vertical yield of the nanowires grown on the buffer layer is over 97% and we also find that crystal defects in the buffer layer do not affect the morphology, vertical yield or optical properties of the nanowires significantly.
CD4+NKG2D+ T Cells Exhibit Enhanced Migratory and Encephalitogenic Properties in Neuroinflammation (2013)

Migration of encephalitogenic CD4(+) T lymphocytes across the blood-brain barrier is an essential step in the pathogenesis of multiple sclerosis (MS). We here demonstrate that expression of the co-stimulatory receptor NKG2D defines a subpopulation of CD4(+) T cells with elevated levels of markers for migration, activation, and cytolytic capacity especially when derived from MS patients. Furthermore, CD4(+)NKG2D(+) cells produce high levels of proinflammatory IFN-γ and IL-17 upon stimulation. NKG2D promotes the capacity of CD4(+)NKG2D(+) cells to migrate across endothelial cells in an in vitro model of the blood-brain barrier. CD4(+)NKG2D(+) T cells are enriched in the cerebrospinal fluid of MS patients, and a significant number of CD4(+) T cells in MS lesions coexpress NKG2D. We further elucidated the role of CD4(+)NKG2D(+) T cells in the mouse system. NKG2D blockade restricted central nervous system migration of T lymphocytes in vivo, leading to a significant decrease in the clinical and pathologic severity of experimental autoimmune encephalomyelitis, an animal model of MS. Blockade of NKG2D reduced killing of cultivated mouse oligodendrocytes by activated CD4(+) T cells. Taken together, we identify CD4(+)NKG2D(+) cells as a subpopulation of T helper cells with enhanced migratory, encephalitogenic and cytotoxic properties involved in inflammatory CNS lesion development.
Design of Flight Controllers based on Simplified LPV model of a UAV (2006)

In this paper, two strategies for the design of controllers based on a simplified LPV model of a UAV (longitudinal flight dynamics) are presented. The simplified LPV model is first derived from a UAV LPV model over the entire range of the cruise speed. The dependence of the LPV model on the varying parameter is reformulated in terms of a mu synthesis problem. A straight mu design and a gain-scheduling mu control scheme have been considered. Simulation results of the closed loop system comprising the controllers and original state-space models are presented and compared
An improved quality PAL decoder (1990)

The motivations for the final system choices of a commercial improved quality PAL receiver are described. The receiver is based on fixed spatio-temporal filters for luminance-chrominance separation. The filters were designed according to hardware complexity and subjective performance evaluation, and according to three-dimensional spectral analysis tests which are nonstandard in television practice. Particular emphasis is placed on the demonstration of the practical feasibility of nontrivial spatio-temporal filters in commercial PAL decoders and on the use of nonconventional frequency domain analysis as an effective performance assessment tool for television systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mercury Adsorption Properties of Sulfur-Impregnated Adsorbents (2002)

Carbonaceous and noncarbonaceous adsorbents were impregnated with elemental sulfur to evaluate the chemical and physical properties of the adsorbents and their equilibrium mercury adsorption capacities. Simulated coal combustion flue gas conditions were used to determine the equilibrium adsorption capacities for Hg0 and HgCl2 gases to better understand how to remove mercury from gas streams generated by coal-fired utility power plants. Sulfur was deposited onto the adsorbents by monolayer surface deposition or volume pore filling. Sulfur impregnation increased the total sulfur content and decreased the total and micropore surface areas and pore volumes for all of the adsorbents tested. Adsorbents with sufficient amounts of active adsorption sites and sufficient microporous structure had mercury adsorption capacities up to 4,509 μg Hg/g adsorbent. Elemental sulfur, organic sulfur, and sulfate were formed on the adsorbents during sulfur impregnation. Correlations were established with R2>0.92 between the equilibrium Hg0/HgCl2 adsorption capacities and the mass concentrations of elemental and organic sulfur. This result indicates that elemental and organic sulfur are important active adsorption sites for Hg0 and HgCl2.