gebhart/patrepeval huggingface dataset:
Acute and Subacute Ischemic Stroke at High-Field-Strength (3.0-T) Diffusion-weighted MR Imaging: Intraindividual Comparative Study (2005)

Although 3.0-T DW MR imaging generates greater image distortions, it yields increased SNR and CNR compared with DW MR imaging at 1.5 T. The increased CNR at 3.0 T translates into a significantly improved diagnostic confidence in the detection of focal apparent diffusion coefficient changes in the setting of subacute and acute ischemic stroke.
ANALYSIS OF CLINICAL RESULTS OF DISCAL PROSTHESES AS A FUNCTION OF THE TYPE OF DEGENERATIVE DISCOPATHY (2008)

Purpose of the study: Discal arthroplasty is warranted as a part of the treatment of discopathy to guarantee mobility after disc removal. Depending on the type of discopathy, the diseased disc can be classified into different categories: absence of herniation (H0), disc herniation (H1), recurrent disc herniation (H2), post discectomy syndrome (H3), or stenosis of a single unit (including grade 1 degenerative spondylolisthesis) (St-SPd). The purpose of this study was to compare clinical outcome after discal arthroplasty for these different clinical situations. Material and methods: This was a prospective study of 152 patients who underwent a single-stage operation for insertion of a lumbar disc prosthesis. Pain was assessed with a visual analog scale for the lumbar level (VAS-L), and for radicular pain (VAS-R) and the Oswestry index (ODI). Patients were classified as follows: 39 H0, 52 H1, 22 H2, 29 H3, 10 ST-SPd). Results: Outcome in patients in groups H0, H1, and St-SPd, i.e. first-intention surgery patients, presented equivalent results for lumbar and radicular pain and for function: VAS-L and VAS-R declined concomitantly. Results at three months postop were equivalent to those observed at 24 months. Patients in groups H2 and H3 who had had prior operation(s) for posterior discectomy experienced rapid relief of lumbar pain but radicular pain persisted postoperatively (6 to 12 m). Discussion: These data confirm the excellent results obtained with single-level disc replacement as assessed by VAS and ODI. The persistence of radiculalgia which then resolves several months later in patients with a history of discal surgery can be explained by the combination of chronic compression, postoperative adherences and restored disc height. In the present series, none of the patients required complementary surgery for posterior radicular release. Conclusion: Discal arthroplasty provides satisfactory results for the different stages of discal disease. The procedure should however be undertaken with prudence for patients who have had prior surgery. A perfect analysis of other factors involved should be helpful in chosing the most appropriate technique and avoid the development of postoperative radiculalgia. The present results could be usefully confirmed with a long-term randomized prospective study comparing discal prosthesis with fusion for the treatment of discal disease.
Generic, scalable and decentralized fault detection for robot swarms (2017)

Robot swarms are large-scale multirobot systems with decentralized control which means that each robot acts based only on local perception and on local coordination with neighboring robots. The decentralized approach to control confers number of potential benefits. In particular, inherent scalability and robustness are often highlighted as key distinguishing features of robot swarms compared with systems that rely on traditional approaches to multirobot coordination. It has, however, been shown that swarm robotics systems are not always fault tolerant. To realize the robustness potential of robot swarms, it is thus essential to give systems the capacity to actively detect and accommodate faults. In this paper, we present a generic fault-detection system for robot swarms. We show how robots with limited and imperfect sensing capabilities are able to observe and classify the behavior of one another. In order to achieve this, the underlying classifier is an immune system-inspired algorithm that learns to distinguish between normal behavior and abnormal behavior online. Through a series of experiments, we systematically assess the performance of our approach in a detailed simulation environment. In particular, we analyze our system's capacity to correctly detect robots with faults, false positive rates, performance in a foraging task in which each robot exhibits a composite behavior, and performance under perturbations of the task environment. Results show that our generic fault-detection system is robust, that it is able to detect faults in a timely manner, and that it achieves a low false positive rate. The developed fault-detection system has the potential to enable long-term autonomy for robust multirobot systems, thus increasing the usefulness of robots for a diverse repertoire of upcoming applications in the area of distributed intelligent automation.
833: Impact of the SRD5A2 A49T Genetic Polymorphism on Progression After Prostatectomy Among Caucasian and African American Men (2004)

You have accessJournal of UrologyDiscussed Poster, Monday, May 10, 2004, 8:00am - 12:00 pm1 Apr 2004833: Impact of the SRD5A2 A49T Genetic Polymorphism on Progression After Prostatectomy Among Caucasian and African American Men Isaac J. Powell, Wael A. Sakr, C. Butler, J.Y. Zhou, Y. Sun, C. Wang, N.P. Patel, L. Heilbrun, and Richard Everson Isaac J. PowellIsaac J. Powell More articles by this author , Wael A. SakrWael A. Sakr More articles by this author , C. ButlerC. Butler More articles by this author , J.Y. ZhouJ.Y. Zhou More articles by this author , Y. SunY. Sun More articles by this author , C. WangC. Wang More articles by this author , N.P. PatelN.P. Patel More articles by this author , L. HeilbrunL. Heilbrun More articles by this author , and Richard EversonRichard Everson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38082-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "833: Impact of the SRD5A2 A49T Genetic Polymorphism on Progression After Prostatectomy Among Caucasian and African American Men." The Journal of Urology, 171(4S), p. 220 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 220 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Isaac J. Powell More articles by this author Wael A. Sakr More articles by this author C. Butler More articles by this author J.Y. Zhou More articles by this author Y. Sun More articles by this author C. Wang More articles by this author N.P. Patel More articles by this author L. Heilbrun More articles by this author Richard Everson More articles by this author Expand All Advertisement PDF downloadLoading ...
Self-Consistent Calculations of Block Copolymer Solution Phase Behavior (1998)

We present a theoretical study of the influence of solvent on ordered block copolymer solutions. The phase behavior is examined as a function of solvent selectivity, temperature, copolymer concentration, composition, and molecular weight. Phase maps are constructed using self-consistent mean-field (SCMF) theory, via the relative stability of the “classical” phases, lamellae (L), hexagonally packed cylinders (C), and a body-centered cubic array of spheres (S). Solvent selectivity and polymer concentration strongly influence phase transitions in copolymer solutions. When a neutral good solvent is added to a symmetric block copolymer, a direct (lyotropic) transition from L to disordered (D) is expected, analogous to the (thermotropic) L → D transition in melts. Indeed for neutral good solvents the dilution approximation is followed: the phase map is equivalent to that in the melt, once the interaction parameter is multiplied by the copolymer volume fraction. In contrast, for a symmetric block copolymer in the presence of a slightly selective solvent, the progression L → C → S → micelles → D is expected, although the micellar phase is not treated here. For asymmetric copolymers more elaborate sequences are anticipated, such as the progression CB → L → CA → SA → micelles → D. The stability limit of a homogeneous block copolymer solution is also examined via the random phase approximation (RPA) method. The effect of polymer concentration on the spinodal instability falls into two regimes. When the solvent is not very selective, the stable microphase separation region is reduced as polymer concentration decreases, whereas for very selective solvents, whereas for very selective solvents decreasing polymer concentration broadens the region of stable ordered microstructures.
Abl Family Nonreceptor Tyrosine Kinases Modulate Short-Term Synaptic Plasticity (2003)

Abl family nonreceptor tyrosine kinases regulate cell morphogenesis through functional interactions with the actin cytoskeleton. The vertebrate Abl family kinases, Abl and Arg, are expressed in the adult mouse brain, where they may regulate actin cytoskeletal dynamics in mature neurons. Using immunoelectron microscopy, we have localized Abl and Arg to the pre- and postsynaptic compartments of synapses in the mouse hippocampal area CA1. Paired-pulse facilitation (PPF) was significantly reduced at the Schaffer collateral-CA1 (SC-CA1) excitatory synapses in hippocampal slices from abl-/- and arg-/- mice as compared with wild-type mice. Furthermore, treatment of wild-type slices with the specific Abl family kinase inhibitor STI571 also reduced PPF. Basal synaptic transmission, posttetanic potentiation (PTP), long-term potentiation (LTP), and long-term depression (LTD) were similar to wild-type controls in abl-/- and arg-/- slices and in STI571-treated wild-type slices. These results indicate that an important function of Abl and Arg is to modulate synaptic efficacy via a presynaptic mechanism during repetitive activation.
CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages. (1999)

Activated macrophages require l-arginine uptake to sustain NO synthesis. Several transport systems could mediate this l-arginine influx. Using competition analysis and gene-expression studies, amino acid transport system y+ was identified as the major carrier responsible for this activity. To identify which of the four known y+ transport-system genes is involved in macrophage-induced l-arginine uptake, we used a hybrid-depletion study in Xenopus oocytes. Cationic amino acid transporter (CAT) 2 antisense oligodeoxyribonucleotides abolished the activated-macrophage-mRNA-induced l-arginine transport. Together with expression studies documenting that CAT2 mRNA and protein levels are elevated with increased l-arginine uptake, our data demonstrate that CAT2 mediates the l-arginine transport that is required for the raised NO production in activated J774 macrophages.
Supplementary Figure from Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer (2023)

Supplementary Figure from Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer
Immunofluorescent Detection of Herpesvirus Antigens in Exfoliated Cells from Human Cervical Carcinoma (1970)

Exfoliated cells from patients with squamous carcinoma of the cervix contain antigens related to herpesvirus subtype 2, as revealed by direct or indirect immunofluorescent techniques. Normal squamous cells from the same subjects and from controls without the disease, and cells from a small number of tumors at sites other than the cervix, did not react with anti-herpesvirus subtype 2 serum. Antisera to adenovirus 18 or mycoplasma orale did not react with the exfoliated cells.
Kinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay (2015)

Chikungunya virus (CHIKV) capsid protein (CVCP) is a serine protease that possesses cis-proteolytic activity essential for the structural polyprotein processing and plays a key role in the virus life cycle. CHIKV being an emerging arthropod-borne pathogenic virus, is a public health concern worldwide. No vaccines or specific antiviral treatment is currently available for chikungunya disease. Thus, it is important to develop inhibitors against CHIKV enzymes to block key steps in viral reproduction. In view of this, CVCP was produced recombinantly and purified to homogeneity. A fluorescence resonance energy transfer (FRET)-based proteolytic assay was developed for high throughput screening (HTS). A FRET peptide substrate (DABCYL-GAEEWSLAIE-EDANS) derived from the cleavage site present in the structural polyprotein of CVCP was used. The assay with a Z' factor of 0.64 and coefficient of variation (CV) is 8.68% can be adapted to high throughput format for automated screening of chemical libraries to identify CVCP specific protease inhibitors. Kinetic parameters Km and kcat/Km estimated using FRET assay were 1.26 ± 0.34 μM and 1.11 × 10(3) M(-1) sec(-1) respectively. The availability of active recombinant CVCP and cost effective fluorogenic peptide based in vitro FRET assay may serve as the basis for therapeutics development against CHIKV.
Activated Factor VIII inTherapeutic Preparations:Analysis by Ultracentrifugation (1996)

Activation of factor VIII is signaled by an increase in the 1-stage factor VIII activity and release from von Willebrand factor. Ultracentrifugation in 10-40% sucrose gradients was used to identify such activation in therapeutic concentrates. Plasma-derived factor VIII lots were examined and factor VIII sedimenting independently of von Willebrand factor was identified in some of the preparations. In addition there was slower sedimentation of factor VIII by the 1-stage assay than by the chromogenic assay. These results are consistent with a factor VIII cleaved at residue 1689, a site important for von Willebrand binding. This activated form leads to some of the assay discrepancies between the 1-stage assay and the chromogenic or the 2-stage assay. There is more rapid sedimentation of the factor VIII measured by the chromogenic assay than the von Willebrand factor in some manufacturers' samples indicating that the method of fractionation may select a low molecular weight von Willebrand factor which does not bind factor VIII. Routine comparison between the 1-stage and chromogenic assays during fractionation may be able to identify such activated preparations. Other assay discrepancies may be due to structural differences between the standards and the tested product.
Evidence of a Dominant Backward-Propagating “Suction” Wave Responsible for Diastolic Coronary Filling in Humans, Attenuated in Left Ventricular Hypertrophy (2006)

Six waves predominantly drive human coronary blood flow. Coronary flow peaks in diastole because of the dominance of a "suction" wave generated by myocardial microcirculatory decompression. This is significantly reduced in LVH.
[Results of surgical treatment for pulmonary aspergilloma in postlobectomy patients]. (2000)

The purpose of this study was to evaluate the results of surgical treatment of postlobectomy pulmonary aspergilloma. Between January 1986 and September 1999, six patients were surgically treated. Aspergilloma were diagnosed on the basis of the clinical and radiographic findings in all cases. All patients were poor pulmonary function. Space-reducing surgery was performed in 5 patients, completion pneumonectomy was performed in 1 patient. The reoperation was only one, the clinical impression of the cause was too difficult direct closure of the bronchial fistula due to formation of marginal fistula. We believe that space-reducing surgery for postlobectomy patients with pulmonary aspergilloma is useful and benefit treatment.
Detection of Respiratory Events During NPSG: Nasal Cannula/Pressure Sensor Versus Thermistor (1997)

Recording of respiratory airflow is an integral part of polysomnography (NPSG). It is conventionally monitored with a thermistor that measures temperature as a surrogate of flow. The subjectivity of interpreting hypopnea from this signal has prompted us to measure nasal airflow directly with a simple pneumotachograph consisting of a standard nasal cannula connected to a 2-cm H2O pressure transducer. We manually analyzed respiratory events using simultaneous thermistor and nasal cannula in 11 patients with obstructive sleep apnea syndrome (OSAS) and 9 with upper airway resistance syndrome (UARS). Definite events were scored separately for each signal when amplitude was <50% for >10 seconds. Events were also scored on the nasal cannula signal when the flattened shape of the signal suggested flow limitation, and these were tabulated separately. Definite events in one signal were tabulated by whether the other signal showed a definite event or not. In addition, nasal cannula events were compared to a more liberal thermistor criterion (any change in the signal for > or = 2 breaths). Visually, events were more easily recognized on the nasal cannula signal than on the thermistor signal. In OSAS, 1,873 definite thermistor events were detected. Of these, 99.1% were detected by nasal cannula, and 0.9% were missed. Of 3,541 definite nasal cannula events, 51.9% were detected by definite thermistor criteria; 75.0% were detected by liberal thermistor criteria; 25.0% were missed. In UARS, 123 definite thermistor events were detected. Of these, 89.4% were detected by nasal cannula and 10.6% were missed. Nine hundred and three nasal cannula events were detected. However, only 17.2% of these were detected by definite thermistor criteria; 38.6% were detected by liberal thermistor criteria; 61.4% were completely undetected by thermistor. When events identified on the nasal cannula by flow limitation alone were excluded, the thermistor detected 30.1% of events by definite criteria and 78.6% by liberal criteria, still leaving 21.4% completely undetected by the thermistor. We conclude that the nasal cannula reliably detects respiratory events seen by thermistor. Additional events (including some characterized only by flow limitation) that help define the UARS, were recognized by nasal cannula but often completely missed by thermistor. We propose that respiratory monitoring during NPSG with nasal cannula significantly improves event detection and classification over that with thermistor.
Solidification and cooling analysis of aluminum alloy droplets with the uniform droplet spray process (1997)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1997.
Expression of a mutant α-zein creates the <i>floury</i> 2 phenotype in transgenic maize (1997)

The maize floury2 mutation results in the formation of a soft, starchy endosperm with a reduced amount of prolamin (zein) proteins and twice the lysine content of the wild type. The mutation is semidominant and is associated with small, irregularly shaped protein bodies, elevated levels of a 70-kDa chaperone in the endoplasmic reticulum, and a novel 24-kDa polypeptide in the zein fraction. The 24-kDa polypeptide is a precursor of a 22-kDa alpha-zein protein that is not properly processed. The defect is due to an alanine-to-valine substitution at the C-terminal position of the signal peptide, which causes the protein to be anchored to the endoplasmic reticulum. We postulated that the phenotype associated with the floury2 mutation is caused by the accumulation of the 24-kDa alpha-zein protein. To test this hypothesis, we created transgenic maize plants that produce the mutant protein. We found that endosperm in seeds of these plants manifests the floury2 phenotype, thereby confirming that the mutant alpha-zein is the molecular basis of this mutation.
Pre-stack migration of three-dimensional seismic data (1996)

This is the final report of a two-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The project sought to develop and test a three-dimensional pre-stack migration code to run on the Los Alamos CM5. This work was done in collaboration with Texaco. The authors implemented a version of Texaco`s phase-shift with interpolation algorithm on the CM5. The authors also tested the algorithm on the Cray T3D in collaboration with Cray participants. Processing of seismic data is extremely computer and I/O intensive. The authors developed methods for efficiently performing both I/O and computing as appropriate for a large three-dimensional seismic dataset. The result was improved capability to image subsurface structures in the earth. The emphasis was on structures that are beneath salt in the US Gulf Coast, where many oil and gas reserves are known to exist but where identifying them from surface seismic data is currently difficult due to the large impedance contrast between the salt and surrounding strata.
Etude de la transmission du champignon Alternaria brassicicola à la semence d’Arabidopsis thaliana (2013)

National audience
P-HDI-07 2-DOF ANALYSIS OF FRICTION-INDUCED SLIDER VIBRATIONS IN A NEAR-CONTACT REGIME (2003)

This paper presents an analytical and experimental study of friction-induced bouncing vibrations of a flying head slider in a near-contact regime by using a 2-DOF slider model in a translation and pitch motion. During calculation of contact force characteristics between the trailing pad and disk, we considered asperity contact including bulk deformation, adhesive force of lubricant and friction force in the real contact area. We numerically simulated the dynamic behavior of the slider in the near-contact regime. As a result, we can obtain the hysteresis behavior of slider bouncing vibration and severe bouncing vibration with some super-harmonics as seen in the experiment.
Direct Observation of Confinement-Induced Charge Inversion at a Metal Surface (2015)

Surface interactions across water are central to areas from nanomedicine to colloidal stability. They are predominantly a combination of attractive but short-ranged dispersive (van der Waals) forces, and long-ranged electrostatic forces between the charged surfaces. Here we show, using a surface force balance, that electrostatic forces between two surfaces across water, one at constant charge while the other (a molecularly smooth metal surface) is at constant potential of the same sign, may revert smoothly from repulsion to attraction on progressive confinement of the aqueous intersurface gap. This remarkable effect, long predicted theoretically in the classic Gouy-Chapman (Poisson-Boltzmann) model but never previously experimentally observed, unambiguously demonstrates surface charge reversal at the metal-water surface. This experimental confirmation emphasizes the implications for interactions of dielectrics with metal surfaces in aqueous media.
On the Phytoalexin production of the soybean pod in reaction to Fusarium sp., the causal fungus of pod blight (1959)

Phytoalexin (PA for short) production of the soybean pod in reaction to Fusarium sp., as affected by conditions of spore suspension, was studied. PA was produced remarkably when suspensions containing spores more than 40per one microscopic field at 150-fold magnification, were placed on the soybean pod, while not at all when suspension with 3∼6 spores per one microscopic field was used. Both spore suspension heated at 100°C for 10 minutes and supernatant of suspension suspended with macerated spores, failed to induce production of PA. The supernatant of spore suspension, incubated for 24 hours at 23°C, revealed to possess ability to induce PA production, but lost the ability when the supernatant was heated at 60°C for 10 minutes.