gebhart/patrepeval huggingface dataset:
Abstract 18473: ApoB-100 Related Peptide Immunization Confers Protection Against Angiotension II-induced Renal Inflammatory Responses (2012)

Background: T cells play an important role in angiotensin II (AngII)-induced hypertension and aneurysm formation. Inflammatory responses, typified by reactive oxygen species (ROS) and Interleukin-6 (IL-6), are involved in AngII-induced hypertension and renal damage. We recently demonstrated that immunization with apoB-100 related peptide p210 reduced atherosclerosis through T cell mediated immune response in apoE (-/-) mice. We also reported that immunization with p210 reduced mean arterial blood pressure (p210 = 124±4*, cBSA = 143±6, PBS = 139±3 mmHg. *p<0.05 vs cBSA and PBS.) and aneurysm formation in AngII-infused apoE (-/-) mice. In this study, we assessed the effect of p210 vaccine on AngII-induced renal inflammatory responses in apoE (-/-) mice. Method and Results: ApoE (-/-) mice were immunized with p210/cBSA/Alum (p210; 100 μ g) at 7, 10, and 12 weeks of age. Mice receiving PBS or cBSA/Alum (cBSA) served as controls. At 10 weeks of age, mice were subcutaneously implanted with an osmotic pump which released AngII (1 mg/Kg/min), and were euthanized 4 weeks later. Serum creatinine level was significantly lower in p210 group (p210 = 0.7±0.1*, cBSA = 1.1±0.1, PBS = 1.4±0.1 mg/dL. N=12, 11, and 9 respectively; *p<0.05 vs cBSA and PBS.). IL-6 and monocyte chemotactic protein-1 (MCP-1) mRNA expression in kidneys were significantly down-regulated in p210 group (IL-6: cBSA = 4.1±1.1, PBS = 3.9±1.0 -fold increase compared to p210; MCP-1: cBSA = 2.4±0.6, PBS = 2.2±0.4 -fold increase compared to p210, N=8). Renal glomerular superoxide production measured by in situ dihydroethidium was significantly decreased in p210 group (cBSA = 3.8±0.7, PBS = 3.9±0.6 -fold increase compared to p210, N=4.). The expression of NOX1, a component of NADPH oxidase, mRNA in kidneys was significantly down-regulated in p210 group (cBSA = 2.6±0.5, PBS = 2.8±0.4 -fold increase compared to p210, N=8.). Conclusion: Immunization with p210 significantly attenuated AngII-induced renal damage. These anti-hypertensive and renal protective effects were associated with down-regulation of IL-6 and MCP-1 expression, and ROS production mediated by NADPH oxidase in kidneys.
Comparison of FISH, PCR, and Immunohistochemistry in Assessing EGFR Status in Lung Adenocarcinoma and Correlation With Clinicopathologic Features (2009)

The purpose of this study is to investigate the relationship between mutation status, copy number, and protein expression of epidermal growth factor receptor (EGFR) in lung adenocarcinoma, and to correlate the genetic status and clinicopathologic features. Forty-nine adenocarcinomas were tested by polymerase chain reaction (PCR) for EGFR gene mutations, by fluorescence in situ hybridization (FISH) for increased EGFR gene copy number, and by immunohistochemistry (IHC) for EGFR protein expression. Terminal respiratory unit (TRU) morphology, tumor grade, mitotic count, and pleural and lymphovascular invasion were also examined. Five of 49 tumors (10%) had EGFR mutation by PCR. Eighteen (36%) had high EGFR gene copy number by FISH, all of which were polysomies without gene amplification. Fifteen (31%) had EGFR protein overexpression by IHC, 13 (87%) of which were also positive by FISH. Of the PCR-positive cases, 4/5 (80%) were positive by FISH and 3/5 (60%) were positive by IHC. TRU morphology was observed in all PCR-positive cases and in about 50% of FISH-positive and IHC-positive cases. Pleural invasion was significantly more common in IHC and FISH-positive cases, and lymphovascular invasion was more often present in FISH-positive cases. No statistically significant differences in mitotic count, age, sex, smoking status, degree of differentiation, or stage were seen. Our findings suggest that a staged approach, with FISH testing as the first step, followed by PCR for the FISH-negative cases would be most effective in the identification of patients with EGFR gene alterations.
ChemInform Abstract: Calixarene Assemblies (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Series resistance compensation in translinear circuits (1998)

The base resistance is often the primary limitation factor for the accuracy in translinear circuits. A general compensation technique for the extrinsic base resistance and the emitter series resistance is presented in this paper. The applications discussed include proportional-to-absolute-temperature (PTAT) temperature sensors and bandgap references.
Differential Stimulation of PKC Phosphorylation of Potassium Channels by ZIP1 and ZIP2 (1999)

Targeting of protein modification enzymes is a key biochemical step to achieve specific and effective posttranslational modifications. Two alternatively spliced ZIP1 and ZIP2 proteins are described, which bind to both Kvbeta2 subunits of potassium channel and protein kinase C (PKC) zeta, thereby acting as a physical link in the assembly of PKCzeta-ZIP-potassium channel complexes. ZIP1 and ZIP2 differentially stimulate phosphorylation of Kvbeta2 by PKCzeta. They also interact to form heteromultimers, which allows for a hybrid stimulatory activity to PKCzeta. Finally, ZIP1 and ZIP2 coexist in the same cell type and are elevated differentially by neurotrophic factors. These results provide a mechanism for specificity and regulation of PKCzeta-targeted phosphorylation.
Automated unit test generation for evolving software (2015)

As developers make changes to software programs, they want to ensure that the originally intended functionality of the software has not been affected. As a result, developers write tests and execute them after making changes. However, high quality tests are needed that can reveal unintended bugs, and not all developers have access to such tests. Moreover, since tests are written without the knowledge of future changes, sometimes new tests are needed to exercise such changes. While this problem has been well studied in the literature, the current approaches for automatically generating such tests either only attempt to reach the change and do not aim to propagate the infected state to the output, or may suffer from scalability issues, especially when a large sequence of calls is required for propagation. We propose a search-based approach that aims to automatically generate tests which can reveal functionality changes, given two versions of a program (e.g., pre-change and post-change). Developers can then use these tests to identify unintended functionality changes (i.e., bugs). Initial evaluation results show that our approach can be effective on detecting such changes, but there remain challenges in scaling up test generation and making the tests useful to developers, both of which we aim to overcome.
Analysis and implementation of a new soft switching DC/DC PWM converter (2013)

This study presents a new DC/DC converter with series‐connected transformers to achieve zero voltage switching (ZVS) for power switches, less transformer secondary winding and partial ripple current cancellation. Two three‐level circuits using the same active switches are operated with interleaved half switching cycle. The voltage stress of all switches is clamped at V in /2. The transformers secondary windings are connected in series to balance the primary side currents. The current‐doubler rectifier is adopted on the output side. Thus, the output inductor ripple currents can be partially cancelled each other and the resultant ripple current at the output capacitor is reduced compared with the output ripple current of the centre‐tapped rectifier topology. Based on the resonant behaviour by the output capacitance of active switches and the leakage inductance (or external inductance), all power switches are turned on at ZVS. Laboratory experiments with a 1 kW prototype, verifying the effectiveness of the proposed converter, are described.
Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies (1999)

Contents Preface * Preface to The New Honest Herbal (ital) * Preface to The Honest Herbal (ital), Third Edition * Preface to Tyler's Honest Herbal, (ital) Fourth Edition * Pros and Cons * Laws and Regulations * I. Herbs and Related Remedies * Alfalfa * Aloe * Angelica * Apricot Pits (Laetrile) * Arnica * Barberry * Bayberry * Betony * Black Cohosh * Blue Cohosh * Boneset * Borage * Bran * Broom * Buchu * Burdock * Butcher's-Broom * Caffeine-Containing Plants * Calamus * Calendula * Canaigre * Capsicum * Catnip * Cat's Claw * Celery Seed * The Chamomiles and Yarrow * Chaparral * Chickweed * Chicory * Coltsfoot * Comfrey * Cranberry * Cucurbita * Damiana * Dandelion * Devil's Claw * Dong Quai * Echinacea * Ephedra (Ma Huang) * Evening Primrose * Eyebright * Fennel * Fenugreek * Feverfew * Fo-Ti (He-Shou-Wu) * Garcinia * Garlic and Other Alliums * Gentian * Ginger * Ginkgo * Ginseng and Related Herb * Goldenseal * Gotu Kola * Grape Seed Extract * Hawthorn * Hibiscus * Honey * Hops * Horehound * Horsetail * Hydrangea * Hyssop * Jojoba Oil * Juniper * Kava * Kelp * Lettuce Opium * Licorice * Life Root * Linden Flowers * Lobelia * Lovage * Milk Thistle * Mistletoe * Mormon Tea * Muira Puama * Mullein * Myrrh * Nettle * New Zealand Green-Lipped Mussel * Pangamic Acid (Vitamin B 15) * Papaya * Parsley * Passion Flower * Pau d'Arco * Pennyroyal * Peppermint * Pokeroot * Pollen * Propolis * Pygeum * Raspberry * Red Bush Tea * Red Clover * Rose Hips * Rosemary * Royal Jelly * Rue * Sage * St. John's Wort * Sarsaparilla * Sassafras * Savory * Saw Palmetto * Schisandra * Scullcap * Senega Snakeroot * Senna * Spirulina * Suma * Tansy * Tea Tree * L-Tryptophan * Uva Ursi * Valerian * Wild Yam * Witch Hazel * Wormwood * Yellow Dock * Yohimbe * Yucca * Summarized Evaluation of Herbal Remedies * Summary Chart * Index * Reference Notes Included
Sol-gel Cyclic Self-Production of α-Al2O3 Nanoseeds as a Convenient Route for the Low Cost Preparation of Dense Submicronic Alumina Sintered Monoliths (2002)

The excellent properties of α-Al2O3 are extremely dependent on the microstructural characteristics of the ceramic materials, which stress out the importance of designing new processing routes and/or improving the existing ones to reach a rigorous microstructural control on the final material. Here, a novel sol-gel self-production method for α-Al2O3 seeds and their application in-situ is demonstrated. The authors show that within an α-Al2O3 seed production cycle with input of a low-cost raw material, pseudoboehmite is adequate for the production of high-densified submicronic α-Al2O3 monoliths.
Integrated Glass Microdevice for Nucleic Acid Purification, Loop-Mediated Isothermal Amplification, and Online Detection (2011)

A microdevice made of glass for genetic analysis has been fabricated, for the first time, for integration of extraction of nucleic acids and loop-mediated isothermal amplification (LAMP), followed by online fluorescence detection of amplification products on a single chip. The nucleic acid (NA) extraction region consists of a microfabricated serpentine channel in which micropillars were etched to increase the channel surface area and the capture efficiency of NAs. Nucleic acid molecules were bound to these pillars and channel surface in the presence of the chaotropic salt guanidine hydrochloride and eluted into a downstream amplification chamber with low ionic strength buffer where loop-mediated isothermal amplification was efficiently performed. Amplification can be detected online by the increase of fluorescence intensity at 540 nm when a low concentration of SYBR Green I, a fluorescent dsDNA intercalating dye, is employed. Flow control was accomplished by using laminar flow and differential channel flow resistances. Through passivation of the LAMP chamber and the channel between the extraction region and amplification domain, effective nucleic acid extraction and amplification were performed by just using a double-channel syringe pump and a heating block. By using this integrated microdevice, the purification of nucleic acids from complex biological matrixes and their subsequent amplification and detection online could be finished within 2 h.
Validation of a metered dose inhaler electronic monitoring device: implications for asthma clinical trial use (2016)

The SmartTouch Ventolin monitor is highly accurate in recording and retaining electronic data. It can be recommended for use in clinical trial settings in which training and quality control systems are incorporated into study protocols to ensure accurate data acquisition.
해외 복수 시장 진출 기업의 제품 매출 이륙 시점 예측 모형에 관한 연구 (2008)

The objective of our study is to provide an exploratory model for forecasting sales take-off timing of a product in the context of multi-national markets. We evaluated the usefulness of key predictors such as multiple market information, product attributes, price, and sales for the forecasting of sales take-off timing by applying the suggested model to monthly sales data for PDP and LCD TV provided by a Korean electronics manufacturer. We have found some important results for global companies from the empirical analysis. Firstly, innovation coefficients obtained from sales data of a particular product in other markets can provide the most useful information on sales take-off timing of the product in a target market. However, imitation coefficients obtained from the sales data of a particular product in the target market and other markets are not useful for sales take-off timing of the product in the target market. Secondly, price and product attributes significantly influence on take-off timing. It is noteworthy that the ratio of the price of the target product to the average price of the market is more important than the price ofthe target product itself. Lastly, the cumulative sales of the product are still useful for the prediction of sales take-off timing. Our model outperformed the average model in terms of hit-rate.
Prevention of adjuvant‐induced cachexia in rats by cyclosporin A (1990)

Summary The changes in food intake and biochemistry following Freund's adjuvant (AJ)‐induced inflammation in rats were investigated. Injection of AJ into rats resulted in a transient anorexia but a sustained decrease in body weight. Within 14 days, body weight decreased by 12% (P<0·05) and adipose tissue (retroperitoneal fat pads) decreased by more than 50%. Biochemical changes seen in association with the AJ‐induced wasting included decreased plasma concentrations of triglyceride and cholesterol. Injection of cyclosporin‐A (CS) (20 mg/kg) with the AJ decreased the anorexia, prevented the sustained loss of body weight and adipose tissue and reversed the effects on plasma triglyceride and cholesterol concentrations. Insulin concentrations were not significantly affected by the AJ or AJ/CS treatments. Peritoneal macrophages from AJ‐treated rats produced 3‐fold more tumour necrosis factor‐α (cachectin) than control rats. This effect was not observed in rats treated with AJ plus CS. The results are consistent with CS preventing the release of cytokines which have anorectic and catabolic actions (IL‐1, TNF), although there is also the possibility that CS has effects involving endocrine mechanisms.
Understanding Morphology (2002)

This is an introductory text on morphology in linguistics, superseded by Haspelmath & Sims (2010).
Flexible PCB-Based 3-D Integrated SiC Half-Bridge Power Module With Three-Sided Cooling Using Ultralow Inductive Hybrid Packaging Structure (2018)

Silicon carbide (SiC) devices are capable of high switching speeds and also enable high switching frequency in power electronic converters. However, this feature poses substantial challenges to packaging, especially limiting the loop inductance. The traditional wire-bonding packaged power module has large parasitic inductance, which will cause voltage overshoot, oscillation, parasitic turn-on, and EMI issues. In order to reduce the parasitic inductance, this paper proposes a flexible printed circuit board (FPCB) based full SiC half-bridge power module with a novel low inductive hybrid packaging structure and three-dimensional (3-D) integration method. This hybrid packaging structure has an ultrathin FPCB substrate stacked on a direct bonding copper (DBC) substrate, which forms a multilayer 3-D power loop. The SiC chips are soldered on the DBC substrate for good thermal dissipation through a cavity in the FPCB substrate. After power loop optimization, the power loop inductance of a 1200-V/120-A SiC power module is only 0.79 nH. The power module consists of three submodules, which are connected by the bendable FPCB substrate. The bendable power module enables maximum utilization of 3-D space. The gate drive, decoupling capacitors, and dc-link capacitors are also integrated and 3D-structured using rigid-flexible PCBs. Moreover, the cooling system is a high-efficiency three-sided cooling structure for the bendable power module. The simulation results show that the three-sided cooling structure reduces the heatsink volume by 50%. Applying this method, the converter can be designed as a system-in-package and a 3D-structured compact system. The power density of a 20-kW three-phase inverter will reach 19.3 kW/L based on this power module. In this paper, the 1200-V/120-A power module fabrication and assembly processes are given. Finally, the static and dynamic experimental comparisons are done for a commercial power module and the proposed power module. The experiment results show that the voltage overshoot of the proposed module reduces about 5.8 times and are consistent with the simulation results. Meanwhile, the proposed power module switching speed is 1.8 times faster than the commercial module under zero external gate resistors and the switching loss can reduce by about 60%.
Selective detection of brominated aromatic compounds using gas chromatography/negative chemical ionization mass spectrometry (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective detection of brominated aromatic compounds using gas chromatography/negative chemical ionization mass spectrometryHans Rudolf. BuserCite this: Anal. Chem. 1986, 58, 14, 2913–2919Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/ac00127a005https://doi.org/10.1021/ac00127a005research-articleACS PublicationsRequest reuse permissionsArticle Views424Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Properties of Hycar 1072-A Carboxylic Nitrile Rubber. (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of Hycar 1072-A Carboxylic Nitrile Rubber.C. Lufter and N. DukeCite this: Ind. Eng. Chem. Chem. Eng. Data Series 1958, 3, 2, 297–304Publication Date (Print):October 1, 1958Publication History Published online1 May 2002Published inissue 1 October 1958https://pubs.acs.org/doi/10.1021/i460004a026https://doi.org/10.1021/i460004a026research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cracks in the β-can: Fluorescent proteins from <i>Anemonia sulcata</i> (Anthozoa, Actinaria) (2000)

We characterize two green fluorescent proteins (GFPs), an orange fluorescent protein, and a nonfluorescent red protein isolated from the sea anemone Anemonia sulcata. The orange fluorescent protein and the red protein seem to represent two different states of the same protein. Furthermore, we describe the cloning of a GFP and a nonfluorescent red protein. Both proteins are homologous to the GFP from Aequorea victoria. The red protein is significantly smaller than other GFP homologues, and the formation of a closed GFP-like beta-can is not possible. Nevertheless, the primary structure of the red protein carries all features necessary for orange fluorescence. We discuss a type of beta-can that could be formed in a multimerization process.
Fluctuations of the quantum stress tensor in curved spacetime via generalized zeta functions and point separation (1999)

We derive the quantum stress tensor two-point function for quantum fields on curved spacetimes. The stress tensor two-point function is derived in terms of: (i)&nbsp; the quantum field's effective action, and (ii)&nbsp; the field's Green function. For both methods, the renormalized stress tensor two-point function is derived. The focus is on spacetimes with an Euclidean section. The renormalized quantum stress tensor two-point function is given in terms of the second variation of the Mellin transform of the trace of the heat kernel for the quantum fields. This form of the two-point function allows the use of generalized zeta function regularization techniques. For systems for which a spectral decomposition of the wave operator is possible, we give exact an exact expression for this two- point function. The large variance signifies the importance of quantum fluctuations and has important implications for the validity of semiclassical gravity theories at sub-Plackian scales...
Notes on Articles Contributed to the Museums of the Royal Gardens, Kew, from the Colonial and Indian Exhibition, 1886 (1887)

J. R. J., Notes on Articles Contributed to the Museums of the Royal Gardens, Kew, from the Colonial and Indian Exhibition, 1886, Bulletin of Miscellaneous Information (Royal Botanic Gardens, Kew), Vol. 1887, No. 9 (1887), pp. 4-21