gebhart/patrepeval huggingface dataset:
Specific Nonpeptide Photoprobes as Tools for the Structural Study of the Angiotensin II AT<sub>1</sub> Receptor (1999)

The aim of this work was to obtain photoactivatable nonpeptide antagonists of the angiotensin II AT(1) receptor. Based on structure-function relationships, two chemical structures as well as appropriate synthetic schemes were chosen as a frame for the design of radiolabeled azido probes. The feasibility of the strategy was first assessed by the synthesis of two tritiated ligands 21 and 22 possessing a high affinity for the AT(1) receptor and a low nonspecific binding to membrane or cell preparations. We then prepared two unlabeled azido derivatives 7 and 14 which retained a fairly high affinity for the AT(1) receptor. The latter compound proved to be suitable for receptor irreversible labeling and was prepared in its tritiated form 28. This tritiated azido nonpeptide probe displayed a K(d) value of 11.8 nM and a low nonspecific binding. It was suitable for specific and efficient covalent labeling of the recombinant AT(1A) receptor stably expressed in CHO cells. The electrophoretic pattern of the specifically labeled entity was strictly identical to that of purified receptor photolabeled with a biotinylated peptidic photoactivatable probe. This new tool should be useful for the mapping of the nonpeptide receptor binding site. These potential applications are discussed in light of the current knowledge of molecular mechanisms of G-protein coupled receptor activation and inactivation.
Effective doses in angiography and interventional radiology: calculation of conversion coefficients for angiography of the lower limbs (2005)

The present study reports on investigations that we have performed to allow the calculation of effective doses (E) in interventional radiology. The use of published conversion tables might not allow sufficient guidance for the establishment of optimization strategies for procedures in interventional radiology. With the Monte Carlo N-Particle transport code (MCNP4B), conversion coefficients, linking dose-area product (DAP) measurements with E, are calculated for angiography of the lower limbs in six hospitals. The influence of various parameters on the calculation of these conversion coefficients is studied in a systematic way using the 2(n) factorial design. In this design the effect of different parameters and their pair-wise interactions on a certain variable is explored. In our study, the relevant parameters are tube potential, total filtration and field size and position. We concluded that the influence of radiation spectrum (kVp + filtration) is large and that the effect of field position and size is moderate, except when differences are observed in respect of the gonads. In that case, the variation in conversion coefficients is large. The results of this statistical analysis are then applied to the differences observed between the conversion coefficients, calculated for angiography of the lower limbs in the six hospitals. Recommendations for optimization of patient doses are given.
RF bandpass filter design using capacitive degeneration (2005)

This work proposes the use of a capacitively degenerated transconductor to construct an RF bandpass filter. The fundamental theoretical elements for the application of this technique are provided. First, the impedance seen from the source/emitter of a transistor with capacitive degeneration and an LC tank connected at its gate/base is analyzed. The conditions under which this impedance exhibits a large value in a narrow bandwidth are obtained showing good agreement between theoretical and simulated results. A general RF filter structure based on the analyzed active resonant cell is introduced and described with a macromodel. A sample 5.2 GHz bandpass filter is designed for a SiGe BiCMOS 0.25 mum process. Simulation results for the designed RF filter show S21 > 6dB, Q > 20 consuming 1 mA from a 2.5 V supply
Aportaciones recientes de la historiografía española a la historia del Derecho indiano (2009)

The paper titled "Recent Contributions of Spanish Historiography to the History of Indiano Law" examines significant contributions to the study of Indiano Law, which was in effect in the Spanish colonies of America from 1492 until the 19th century. It highlights the figure of Rafael Altamira y Crevea as a pioneer in the research on this legal framework, who, from his chair and later from exile in Mexico, promoted the study of Indiano Law in the academic field. Although numerous studies have been conducted on Indiano Law, the paper underscores that important gaps in research still exist, emphasizing areas such as the history of Indiano legal historiography, maritime-mercantile law, and the institutional history of less explored regions, such as the Philippines. Consequently, it concludes that recent research represents a significant advancement in the understanding of the Indiano legal system but still requires greater efforts by scholars to address underexplored aspects
X-ray scattering measurements from thin-foil x-ray mirrors (1992)

Thin foil X-ray mirrors are to be used as the reflecting elements in the telescopes of the X-ray satellites Spectrum-X-Gamma (SRG) and ASTRO-D. High resolution X-ray scattering measurements from the Au coated and dip-lacquered Al foils are presented. These were obtained from SRG mirrors positioned in a test quadrant of the telescope structure and from ASTRO-D foils held in a simple fixture. The X-ray data is compared with laser data and other surface structure data such as STM, atomic force microscopy (AFM), TEM, and electron micrography. The data obtained at Cu K-alpha(1), (8.05 keV) from all the mirrors produced on Al foils shows a scatter which limits the obtainable half-power width to above 1.5 arcmin. Mirrors based on electroformed Ni foils, however, show local regions with a factor of 4 better performance, and they are being developed for future applications.
Development of Die-Bonding Film for Semiconductor Packages Applied Reaction-Induced Phase Separation (2008)

ウェハの極薄化, チップ積層段数の多段化に伴い, ダイボンディングフィルムへの要求特性はより厳しくなっている。われわれはエポキシ樹脂/架橋性アクリルポリマーからなる反応誘起型相分離材料をべースとしたフィルムにおいて, 相分離挙動のコントロールとナノフィラー添加により, 応力緩和性と耐リフロー性を高レベルで両立することに成功した。また, このフィルムはエポキシ樹脂の構造, 比率を変更することにより弾性率, 粘着性などの主要な物性値を幅広く変更できるため, 極薄ウエハを用いた最先端のスタックドパッケージの用途で広汎に使用されるに至った。
Capillary Electrophoresis of Roasted Coffees (2000)

Arabica coffee beans were roasted either at 240-290°C for 3 min or for 2-5 min at 265°C. Aqueous extracts prepared from them, and from unroasted beans, were separated into high molecular weight (HMW) and low molecular weight (LMW) fractions by ultrafiltration, using a membrane with a nominal molecular weight cut-off of 5 000 daltons. Absorption at 460 nm for the aqueous extracts increased with degree of roast. Extracts and fractions were analyzed by capillary zone electrophoresis (CZE) using different buffers. Beans roasted to similar colors gave very similar CZE data, regardless of roasting conditions, the electrophoretograms (e-grams) being characteristic of the degree of processing. A broad peak was obtained for the HMW fraction which increased with degree of roast and which was indicative of a complex mixture of compounds. It contained the majority of the colored material. The data suggest that the aqueous extracts of the roasted coffees are qualitatively similar, regardless of the roasting regime.
Near-Infrared Luminescence of Lanthanide Calcein and Lanthanide Dipicolinate Complexes Doped into a Silica−PEG Hybrid Material (2004)

The near-infrared luminescence of lanthanide complexes of 4‘,5‘-bis[N,N-bis(carboxymethyl)aminomethyl]fluorescein (calcein) and pyridine-2,6-dicarboxylic acid (dipicolinic acid, dpa) doped in a hybrid sol−gel material was investigated. The silica−poly(ethylene glycol) (silica−PEG) inorganic−organic materials were prepared at a neutral pH. The lanthanide ions are well shielded from the environment by the calcein and dpa ligands, and the complexes are stable in the sol−gel matrix after preparation. The dysprosium and neodymium dipicolinate complexes showed near-infrared luminescence (NIR-luminescence) by direct excitation to the 4f-levels. The ytterbium dipicolinate complex doped in the sol−gel showed NIR-luminescence by excitation of the ligand in the UV region. All other tested lanthanide ions (Ln = Pr, Sm, Er, Ho) did not show luminescence. Neodymium and ytterbium complexes with calcein show intense NIR-luminescence when the ligand is excited by visible light. The corresponding erbium complex doped in the silica-PEG matrix also showed NIR-luminescence at 1525 nm. No NIR-luminescence could be detected for the other lanthanide complexes doped in the matrix (Ln = Pr, Sm, Dy, Ho).
ProSAT: functional annotation of protein 3D structures (2003)

ProSAT (for Protein Structure Annotation Tool) is a tool to facilitate interactive visualization of non-structure-based functional annotations in protein 3D structures. It performs automated mapping of the functional annotations onto the protein structure and allows functional sites to be readily identified upon visualization. The current version of ProSAT can be applied to large datasets of protein structures for fast visual identification of active and other functional sites derived from the SwissProt and Prosite databases.
Photodimerization. II. Structure and isomerization of the photodimer of crystalline trans-benzalacetone (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotodimerization. II. Structure and isomerization of the photodimer of crystalline trans-benzalacetoneJohannes Dekker and Theodor G. DekkerCite this: J. Org. Chem. 1968, 33, 6, 2604–2605Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/jo01270a125https://doi.org/10.1021/jo01270a125research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development and evolution intertwined (2011)

One of the most remarkable characteristics of multicellular organisms is the way in which a single seed or a fertilised egg ends up as a fully functional complex organism, bigger in size by orders of magnitude. Science has been slow to uncover the processes involved in these remarkable transformations. As in all such inquiries, simplifications are necessary as aids to discovery. To modern eyes, some of these simplifications seem ridiculous. For example, the microscopists of the late seventeenth century convinced themselves that they could discern in the head of a human sperm a tiny homunculus – a miniature version of the adult. Everything was preformed and development was simply a matter of getting larger. The preformationists were opposed by those who believed in the emergence of an organism from an undifferentiated state. The tiny organism required interaction with the world around it if it was to develop successfully. This was known as ‘epigenesis’ – a term similar to modern ‘epigenetics’ which has, however, acquired a different meaning.
AN APPROACH TO WIRELESS SCHEDULING CONSIDERING REVENUE AND USERS' SATISFACTION (2006)

system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise- except for personal and internal use to the extent permitted by national copyright law- without the permission and/or a fee of the Publisher.
Soybean Nodulin-26 Gene Encoding a Channel Protein Is Expressed Only in the Infected Cells of Nodules and Is Regulated Differently in Roots of Homologous and Heterologous Plants (1993)

Guo-Hua Miao, Desh Pal S. Verma, Soybean Nodulin-26 Gene Encoding a Channel Protein Is Expressed Only in the Infected Cells of Nodules and Is Regulated Differently in Roots of Homologous and Heterologous Plants, The Plant Cell, Vol. 5, No. 7 (Jul., 1993), pp. 781-794
CT of Coronary Artery Disease (2004)

Technical innovation is rapidly improving the clinical utility of cardiac computed tomography (CT) and will increasingly address current technical limitations, especially the association of this test with relatively high levels of radiation. Guidelines for appropriate indications are in place and are evolving, with an increasing evidence base to ensure the appropriate use of this modality. New technologies and new applications, such as myocardial perfusion imaging and dual-energy CT, are being explored and are widening the scope of coronary CT angiography from mere coronary artery assessment to the integrative analysis of cardiac morphology, function, perfusion, and viability. The scientific evaluation of coronary CT angiography has left the stage of feasibility testing and increasingly, evidence-based data are accumulating on outcomes, prognosis, and cost-effectiveness. In this review, these developments will be discussed in the context of current pivotal transitions in cardiovascular disease management and their potential influence on the current role and future fate of coronary CT angiography will be examined.
OSGAR: A Scene Graph with Uncertain Transformations (2005)

An important problem for augmented reality is registration error. No system can be perfectly tracked, calibrated or modeled. As a result, the overlaid graphics are not aligned perfectly with objects in the physical world. This can be distracting, annoying or confusing. In this paper, we propose a method for mitigating the effects of registration errors that enables application developers to build dynamically adaptive AR displays. Our solution is implemented in a programming toolkit called OSGAR. Built upon OpenSceneGraph (OSG), OSGAR statistically characterizes registration errors, monitors those errors and, when a set of criteria are met, dynamically adapts the display to mitigate the effects of the errors. Because the architecture is based on a scene graph, it provides a simple, familiar and intuitive environment for application developers. We describe the components of OSGAR, discuss how several proposed methods for error registration can be implemented, and illustrate its use through a set of examples.
Impact Behavior Analysis of a Mechanical Monoleaflet Heart Valve Prosthesis in the Closing Phase (1992)

An analysis of the dynamics in the closing phase of the occluder of a mechanical monoleaflet heart valve prosthesis is presented. The dynamic analysis of the fluid in the vicinity of the occluder was based on the control vo]use approach. The backflow velocity of the fluid was computed by applying the continuity, Bernoulli's and momentum equations in the unsteady state. By considering the fluid pressure and gravity as external forces acting on the occluder, the moment equilibrium on fine occluder was employed to analyze the motion of the occluder during closing and the force of impact between the occluder and the guiding struts. Occluder comes to rest after several oscillations in about 10-18 msec after the Inltiaton of closing. As the aortic pressure increases, the occludes closes faster and comes to the final resting position earlier and the impact force increases also. But backflow is not af footed by the variation of the aortic pressure. With decreasing time delay of the ventricle pressure, the occluder closes faster and impact force Increases. The computed magnitudes of the occluder tiP velocities as well as the backflow of the fluid during the closing phase using this model were in agreement with previously reported experimental measurements.
Concurrent Measurements of the Vehicular Channel Transfer Function and the 802.11 Received Signal Strength Index (2009)

This paper describes experiments which study the effects of both a stationary and a moving vehicle on the 22 MHz 802.11b and the 20 MHz 802.11a channel transfer functions. Our setup enables concurrent measurements of: (1) the complex channel transfer function with a Vector Network Analyzer (VNA), and (2) the Received Signal Strength Index (RSSI) obtained using off-the-shelf 802.11 cards. Our results show that, for the case of the stationary channel, the average RSSI is a several dBs away from the channel loss measured by the VNA, even with meticulous calibration of the 802.11 cards. The VNA measurements show that a vehicle moving in an environment resembling a multi-lane highway can cause a change in the magnitude of the transfer function on the order of tens of dB. The results of the RSSI measurements show that changes in RSSI caused by the passing vehicle are in the order of magnitude of the ones measured with the VNA.
The Patient for Outpatient Cataract Surgery (1989)

A 73-year-old retired farmer with hypertension and diabetes mellitus was admitted to the outpatient department for surgical treatment of cataract disease. His medications on admission included chlorpropamide 250 mg daily and hydrochlorothiazide 50 mg b.i.d. Before admission his ophthalmologic assessment showed a visual acuity of 20/80 in his right eye.Admission blood work included hematocrit 45% and fasting blood sugar 145 mg/dl. Other chemical analyses (serum electrolytes) were normal. This patient had been seen by an internist in the preoperative assessment clinic one week before admission, at which time his ECG and chest x-ray were normal. There were no other significant abnormalities. The patient was scheduled for elective right cataract extraction and intraocular lens implantation. Regional anesthesia was requested by the ophthalmologist.KeywordsRegional AnesthesiaCataract ExtractionLens FiberIntraocular Lens ImplantationRetrobulbar AnesthesiaThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Managing Risk When Outsourcing Advanced Logistics (2003)

The paper describes and analyses both shipper’s and provider’s risk in outsourcing advanced logistics services. Also the risk management process (including risk analysis, risk assessment and risk management) of both companies are described and discussed. Conclusions are that risk management have been of increasing importance both during and after the outsourcing decision, and that both parties have developed their risk management processes and contingency plans due to the changed risk situation. Contracts play a vital role in risk management; but liability is an issue where there is a gap between the parties as well as in theory.
Détection de changement sur des données géométriques tridimensionnelles (2006)

This work deals with the analysis of 3D point cloud data acquired by ground-based laser sensors in order to detect 3D geometrical changes in complicated environments (such as power plants or oil platforms). Ground-based laser sensors are compact and portable devices that are able to acquire rapidly and accurately a large amount of 3D points on the surface of objects. These point clouds are very dense and detailed, but also huge and unstructured. Therefore, we have developed fast and ad-hoc algorithms to deal with such datasets. This manuscript presents the study and effective implementation of a complete change detection framework on 3D point clouds and 3D mesh models. We mainly propose a method to compute distances directly between two 3D point clouds in a robust and accurate way, and also two segmentation algorithms. The first segmentation algorithm is a region based approach that relies on a local statistical test. It classifies points of a cloud in two categories, depending on the distribution of distances computed for each point and its nearest neighbours. The second algorithm is an edge based approach that relies on a propagation scheme constrained by the gradient norms of the computed distances. We also propose a specific coding scheme of an octree structure. Such a structure can be computed very efficiently and in such a way that most of the point treatments can be optimized and the global process is therefore greatly accelerated. Eventually, we present several industrial applications of our framework. We also investigate the potential advantages that it could bring to a crisis management process, as it is fast and accurate.
A system LSI memory redundancy technique using an ie-Flash (inverse-gate-electrode flash) programming circuit (2002)

A new memory redundancy technique using ie-flash (inverse-gate-electrode flash) memory cells was developed. Ie-flash can be fabricated by the conventional logic CMOS process, so no additional processes are necessary to use it in system LSIs, and it can be programmed by logic tester. This new redundancy technique was successfully implemented in the cache memories of a 32-bit RISC microprocessor.
A novel multifunctional labeling reagent for enhanced protein characterization with mass spectrometry (2001)

Individual peptides with lysine at the C-terminus as well as protein tryptic digests were reacted with 2-methoxy-4,5-dihydro-1H-imidazole, converting lysine residues to their 4,5-dihydro-1H-imidazol-2-yl derivatives. The mass spectra of derivatized digests exhibit a greater number of more intense features than their underivatized counterparts, thus increasing the information obtained in peptide mapping experiments. Additionally, MS/MS spectra of the derivatized peptides are greatly simplified in comparison to their native species, yielding primarily an easily interpretable series of y-ions. Finally, this novel label also enables differential quantitation studies, as a stable isotopic form containing four deuterium atoms can readily be produced.
ChemInform Abstract: Synthesis and Structure of 2‐Ethoxy‐2‐oxo‐3,3,4‐trimethyl‐5‐(2‐ethoxy‐4,4‐bis (trifluoromethyl)‐4H‐1,3,5‐oxadiazin‐6‐yl)imino‐1,4,2‐diazaphospholane (VI). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reaktionen von 2.5-Diäthyl-3.6-dimethyl-2.5-endimino-1.4-dithianen (1978)

Dem Reaktionsverhalten der auso α -Mercaptketonen und Ammoniak bzw. Aminen hergestellten N-unsubstituierten und N-substituierten 2.5-Endimino-1.4-dithiane wurde bisher wenig Beachtung geschenkt. Als einzige Endiminodithian-Reaktion ist bisher nur die Bildung von Hydrohalogeniden bekannt. Aus diesem Grund beschäftigt sich die vorliegende Arbeit bevorzugt mit dem Studium der Reaktionsfähigkeit einiger aus 2-Mercaptopentanon-3 darstellbarer 2.5-Diäthyl-3.6-dimethyl-2.5-endimino-1.4-dithiane.