gebhart/patrepeval huggingface dataset:
Modeling, design, and performance analysis of a parallel hybrid data/command driven architecture system and its scalable dynamic load balancing circuit (1997)

Addresses a proposed parallel hybrid dataflow architecture, a scalable dynamic load balancing circuit for the proposed architecture, and performance analysis, first, of the load balancing circuit and, second, the architecture using the load balancing circuit. The contributions and focus of this paper are: (1) that it first describes the requirements for and the framework of a parallel, medium to coarse grain, hybrid token controlled dataflow architecture. This paper only deals with real-time applications of the architecture. (2) The paper next describes the dynamic load balancing strategy for the hybrid dataflow architecture and a resulting mathematical model of the load balancing function required by the load balancing strategy. (3) The organization, design, and implementation of a basic digital circuit suitable for VLSI implementation which implements the mathematical model of the load balancing function required by the architecture is next presented. This circuit implements a control token mapping function and is therefore called a "token mapper". (4) It is next shown that the basic dynamic load balancing circuit (token mapper) design is scalable therefore allowing the hybrid dataflow architecture to be scalable. (5) The performance of the dynamic load balancing circuit is then analyzed at both the circuit and architectural systems level. A parallel simulation of the proposed parallel hybrid dataflow architecture employing its presented dynamic load balancing circuit was developed for two example applications and used for architectural system level performance analysis. Analysis of simulation results verified correct operation of the proposed hybrid dataflow system architecture and its dynamic load balancing circuit.
A New Preparation of the Diastereoisomeric <i>N</i> -Acetylneuraminic Alditols (2000)

Acylation of the alditols (2) obtained by sodium borohydride reduction of N -acetylneuraminic acid (Neu5Ac) (1) gives a mixture of lactones (3) and (4) which can be separated and deprotected without epimerization yielding pure samples of the diastereoisomeric N -acetylneuraminic alditols (5) and (6).
Syntheses and properties of low-polarity shape mimics of 8oxopurines (2007)

A number of mutations that arise in the cell come from oxidative damage to DNA bases. Oxidation of purine bases at the 8-position, yielding 8-oxoguanosine and 8-oxoadenosine, results in conformation changes that cause miscoding during DNA replication. For example, 8-oxodG in the syn conformation is complementary to adenine in the hydrogen bonding. Here, we report the synthesis, biophysical and biochemical properties of low-polarity shape mimics of 8-oxopurines. A 2-chloro-4-fluoroindole (1) nucleoside was designed as a mimic of 8-oxodG, and a 2-chloro-4-methylbenzimidazole nucleoside (2) as a mimic of 8-oxodA. Structural studies of the free nucleoside revealed that both bases are preferred syn conformation, thus mimicking the conformation of the oxopurine nucleosides. Base pairing studies showed that both compounds in the oligonucleotides pair with selectivity for purine partners. In the DNA template containing new oxopurine analogs, dATP and dGTP were incorporated opposite 1 and 2 respectively by the Klenow. Moreover, 5'-triphosphate derivatives (3 and 4) were incorporated into DNA opposite purine nucleobase. Thus the new analogs are expected to be useful as mechanistic probes cellular responses to DNA oxidative damage.
Development of a High-Sensitivity Immunoassay for C-Reactive Protein on the Cholestech LDX, a Point-of-Care Analyzer (2004)

C-reactive protein (CRP), a systemic marker of inflammation, has been shown to provide prognostic information about the risk of future coronary events, stroke, and development of diabetes in apparently healthy individuals. Elevated baseline levels of CRP are associated with an increased risk of disease, even in the absence of hyperlipidemia and other traditional risk factors. The authors developed a high-sensitivity CRP assay (hs-CRP) on the Cholestech LDX System for use in a point-of-care environment. The Cholestech LDX System is a desktop analyzer that utilizes a dry chemistry cassette and reflectance photometry to quantify analytes. After the sample addition, the cassette is inserted into the LDX for analysis. Plasma is separated from red blood cells and then incubated with a colloidal gold anti-CRP conjugate. A lateral flow system transfers the gold conjugate through an anti-CRP antibody capture zone. Gold conjugate bound to CRP is captured whereas unbound gold conjugate is washed away. The signal in the capture zone is measured by the LDX, which converts percent reflectance directly into a calculated dose result. The precision and accuracy of the LDX hs-CRP assay system was determined. Interassay coefficients of variation averaged 10.6% for whole blood and 8.4% for plasma. Comparison of method studies yielded the following linear regression analysis: whole blood, LDX hs-CRP = 1.08 × Dade Behring hs-CRP + 0.00 (r = 0.982); plasma. LDX hs-CRP = 1.02 × Dade Behring hs-CRP + 0.21 (r = 0.976). The Cholestech LDX hs-CRP assay provides a rapid (7-minute) point-of-care test system for determination of baseline CRP levels from a single drop of blood.
THE ROLES OF ELECTRONIC AND NUCLEAR STOPPING IN THE DESORPTION VALINE NEGATIVE MOLECULAR IONS (1989)

The yield of valine negative molecular ions has been measured as a function of Xe+, Kr+, and Ar+ primary ion velocity. The electronic and nuclear stopping powers are comparable in magnitude and opposite in slope in the experimental velocity region. The yield data are explained in terms of electronic stopping power alone, with no contribution from nuclear stopping power within the experimental error. Low molecular weight atomic species are found to be best described by a nuclear stopping power related process.
Luminescence quenching of dicyanobis(2,2'-bipyridine)ruthenium(II) and dicyanobis(1,10-phenanthroline)ruthenium(II) by transition metal complexes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLuminescence quenching of dicyanobis(2,2'-bipyridine)ruthenium(II) and dicyanobis(1,10-phenanthroline)ruthenium(II) by transition metal complexesJ. N. Demas, J. W. Addington, Steven H. Peterson, and E. W. HarrisCite this: J. Phys. Chem. 1977, 81, 11, 1039–1043Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/j100526a003https://doi.org/10.1021/j100526a003research-articleACS PublicationsRequest reuse permissionsArticle Views296Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Method of Determining Some Aerodynamic Coefficients from Supersonic Free-Flight Tests of a Rolling Missile (1950)

Abstract : Based on the assumption that the aerodynamic forces acting at any point on a lifting surface are linearly dependent upon the local angle of attack at that point, the theory of pure rolling motion is applied to the experimentally observed motion of a finned missile in order to (1) determine how well the actual motion is represented by the theory, (2) determine the suitability of the Aerodynamic Range to the proposed free-flight roll technique, and (3) determine certain aerodynamic coefficients associated with the motion. Values for the aerodynamic coefficients are also derived using the linearized supersonic theory and are compared with those obtained from experiment. The results indicate that the actual motion is well represented by the theory to within the small experimental errors and that excellent re-producibility of the aerodynamic coefficients in roll is obtained. Further - more the results show a fairly good correlation with the linearized theory considering the degree of approximation associated with this theory when applied to aerodynamic surfaces of 16% thickness as employed on the missiles used in the reported tests.
Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site (2004)

In the thyroid, iodotyrosine dehalogenase acts on the mono and diiodotyrosines released during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. It has been reported that the deiodination of iodotyrosines occurs predominantly in the microsomes and is mediated by NADPH. Recently, two cDNAs, 7401- and 7513-base pairs long that encode proteins with a conserved nitroreductase domain were published in GenBank as iodotyrosine dehalogenase 1 (DEHAL1) and iodotyrosine dehalogenase 1B (DEHAL1B), respectively. We report here our investigation of the localization and activity of one of these isoforms, DEHAL1. DEHAL1 mRNA is highly expressed in the thyroid, is up-regulated by cAMP, and encodes a transmembrane protein that efficiently catalyzes the NADPH-dependent deiodination of mono (L-MIT) and diiodotyrosine (L-DIT), with greater activity vs. L-MIT. Iodotyrosine deiodinase was active in HEK293 cells transfected by DEHAL1 cDNA, but not in CHO cells. A fraction of DEHAL1 protein is exposed to the cell surface, as indicated by biotinylation experiments. Immunohistochemistry studies showed that DEHAL1 proteins accumulate at the apical pole of thyrocytes. Taken together, these findings indicate that the deiodination reaction occurs at the apical pole of the thyrocyte and is involved in a rapid iodide recycling process at and/or close to the organification site.
Cation Exchange Capacity and Exchange Coefficients (1996)

The origin of cation exchange capacity (CEC) lies in the negative charges carried by soil particles, usually clay, organic matter and sesquioxides. An excellent parallel discussion of how the views on soil acidity developed during this period is presented by G. W. Thomas. It is interesting to speculate what course CEC method development might have taken had the work been conducted in the humic tropical areas of Latin America, Mrica and Asia where the soils are generally highly acid. The criteria for methodology selection will be divided on a final use basis. Most measurements of exchange coefficients are made at 0.01 to 0.05 M ionic strength, largely in order to provide sufficient solution cations to effect the desired exchange with the solid phase. Arid region soils often contain carbonates and other soluble salts, resulting in complications with respect to the quantities of exchangeable cations extracted.
Carbon dioxide capture using amine functionalized silica gel (2012)

Commercially available silica gel is chemically modified for carbon dioxide capture. Calcinated silica gel of certain particle size functionalized with amine using two different methods, wet impregnation and grafting via silane chemistry has been employed as a porous media. The prepared material is characterized by Fourier transform infrared, scanning electron microscopy, energy dispersive analysis of X-rays, thermogravimetry and N2 physisorption techniques. Gas uptake measurements have been carried out to ascertain the CO2 capture capacity of the amine functionalized material. The experiments have been carried out at moderate pressure and temperature range to ascertain its potential for easy scale up.
Systematic gain-of-function genetics in <i>Drosophila</i> (1998)

A modular misexpression system was used to carry out systematic gain-of-function genetic screens in Drosophila. The system is based on inducible expression of genes tagged by insertion of a P-element vector carrying a GAL4-regulated promoter oriented to transcribe flanking genomic sequences. To identify genes involved in eye and wing development, the 2300 independent lines were screened for dominant phenotypes. Among many novel genes, the screen identified known genes, including hedgehog and decapentaplegic, implicated in these processes. A genetic interaction screen for suppressors of a cell migration defect in a hypomorphic slow border cells mutant identified known genes with likely roles in tyrosine kinase signaling and control of actin cytoskeleton, among many novel genes. These studies demonstrate the ability of the modular misexpression system to identify developmentally important genes and suggest that it will be generally useful for genetic interaction screens.
Synthese, Stereochemie und analgetische Wirkung von 3,7‐Diazabicyclo[3.3.1]nonan‐9‐onen und 1,3‐Diazaadamantan‐6‐onen<sup>1</sup>) (1989)

The 1,3-diazaadamantan-6-ones 13-18 are synthesized from the 4-piperidones 1-3. Different conditions lead to stereoisomeric structures. The 3,7-diazabicyclo[3.3.1]nonan-9-ones 8 and 9 show similar geometrical isomerisms. The configuration is determined by means of 1H-NMR and 13C-NMR spectroscopic data. Whereas the diazabicyclo[3.3.1]nonanones 7 and 12 show opioid-like effects, the diazaadamantanone 13 is a peripheral analgesic.
Microwave Spectrum, Barrier to Internal Rotation, Dipole Moment, and Structure of Trifluoromethylphosphine (1968)

The microwave spectra of CF3PH2, CF3PHD, and CF3PD2 have been observed and analyzed. The barrier to internal rotation is 2360 ± 80 cal/mole, approximately 400 cal/mole higher than the barrier in CH3PH2. The dipole-moment components are μa = 1.77 ± 0.01 D, μc = 0.74 ± 0.03 D, and μtotal = 1.92 ± 0.02 D. The structural parameters are rC−P = 1.900 ± 0.006 Å, rP−H = 1.43 ± 0.08 Å, ∠FCF = 108.0 ± 0.4°, ∠CPH 91.9 ± 1.9°, and ∠HPH = 96.7 ± 1.8°. Compared with CH3PH2, the C-P bond is significantly longer, ∠CPH is smaller, and ∠HPH is larger.
Convenient and stereospecific homologation of N-fluorenylmethoxycarbonyl-α-amino acids to their β-homologues (1997)

A very simple approach to the enantioselective homologation of α-amino acids is presented which is based on the formation of N-Fmoc-aminoacyldiazomethanes with nearly quantitative yields and on the complete retention of both chiral configuration and N-terminal protecting group in the overall transformation.
Mass transfer of zinc-containing compounds during filtration combustion in the counterflow regime. 2. Mass transfer at a high content of zinc oxide in the stock (2009)

A thermodynamic analysis of the equilibrium composition of the gaseous and condensed products for the ZnO-C-O2-N2 system was performed. The characteristics of the filtration combustion and mass transfer of volatile products from model stocks with a high content of zinc oxide were studied. The conditions of combustion of stock samples, degree of extraction of zinc-containing products into sublimate from condensed sample, and the chemical form of zinc-containing compounds released were determined for a wide range of governing parameters.
Central and Peripheral Routes to Advertising Effectiveness: The Moderating Role of Involvement (1983)

Journal Article Central and Peripheral Routes to Advertising Effectiveness: The Moderating Role of Involvement Get access Richard E. Petty, Richard E. Petty Search for other works by this author on: Oxford Academic PubMed Google Scholar John T. Cacioppo, John T. Cacioppo Search for other works by this author on: Oxford Academic PubMed Google Scholar David Schumann David Schumann Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Consumer Research, Volume 10, Issue 2, September 1983, Pages 135–146, https://doi.org/10.1086/208954 Published: 01 September 1983 Article history Received: 01 March 1982 Revision received: 01 April 1983 Published: 01 September 1983
Interaction with Human Immunodeficiency Virus Type 1 Modulates Innate Effector Functions of Human Monocytes (1995)

The effect of human immunodeficiency virus (HIV) type 1 on human mononuclear phagocyte effector functions in response to infection with bacteria of the Mycobacterium avium-intracellular complex (MAC) was investigated. The results showed that interaction of HIV-1 or its constituents with CD4 expressed in the monocyte membrane led to substantial impairment of monocyte capacity to restrict the intracellular growth of MAC. This was accompanied by substantially decreased production of tumor necrosis factor-alpha by HIV-1-exposed and MAC-infected monocytes. However, productive HIV-1 infection of monocytes was not required to induce the observed effects. These studies suggest that HIV-1 may interfere with innate mononuclear phagocyte function. This may be of physiologic importance in the late stages of AIDS, when an impaired T cell immunity can no longer provide proper immune-activating signals, and may help to explain the undue susceptibility to MAC infections in these patients.
Amniotic Fluid 3,3′- and 3f,5′-Diiodothyronine in Fetal Hypothyroidism in Sheep* (1979)

ABSTRACT. The concentration of rT3 in human amniotic fluid (AF) at term is higher than in maternal serum and about 50%that of fetal serum. On the other hand, rT3 concentrations in sheep AF are very low (< 10–20 ng/dl) compared to both maternal (24–85 n/gl) and fetal (400–740 ng/dl) sera. This finding led us to consider the possibility that rT3 in sheep may normally be metabolized to 3,3′-diiodothyronine (3,3′-T2) and/or 3′,5′-T2 and that measurement of T2S in AF may be useful in recognition of fetal hypothyroidism. The concentrations of T2s were measured by specific RIAs in maternal sera and term AF and sera from normal and previously thyroidectomized neonatal (10–60 min of age) sheep; thyroidectomy was performed surgically in utero at 50–93 days gestation (term in sheep is about 145 days). The mean (±SE) serum 3,3′-T2 concentration of 15 ± 12 ng/dl in 3hypothyroid neonates was significantly lower than the corresponding value of 98 ± 7.4 ng/dl in 10 normal neonates (P < 0.001) and lower (borderline) than that of 24 ± 2.4 ng/dl in 9 maternal specimens (0.05 ≶ P < 0.1). Serum 3′,5′-T2 concentrations were undetectable (<1.5 ng/dl) in hypothyroid neonates; the corresponding mean values were 14 ± 1.8 ng/dl in normal neonates and 10 ± 0.6 ng/dl in maternal specimens. The concentrations of 3,3′-T2 [7.5 ± 1.4 (n = 3) vs. 25 ± 1.9 (n = 10) ng/dl; p < 0.001] and 3′,5′-T2 [4.9 ± 1.1 (n = 4) vs. 14 ± 1.3 (n = 9) ng/dl; P < 0.001] in AF of pregnancies with hypothyroid fetuses were also clearly less than those in normal pregnancies. The various data suggest that 1) 3,3′-T2 and 3′,5′-T2 are normally clearly detectable in sheep AF at a time when rT3 (or T3) is very low or undetectable and 2) low AF 3,3′-T2 and 3′,5′-T2 are reliable indicators of fetal hypothyroidism. By inference, AF rT3 may be useful in antenatal diagnosis of hypothyroidism in species (e.g. man) where it is normally present in easily measureable concentrations.
Technology Integration in the Daily Activities of the Elderly. (2008)

A continuous increase of the anticipated average life is expected in the near future. We have to deal with the consequences of aging, such as loneliness in an environment characterized by technology or the need to help elderly people. Technical solutions are required that solve the occurring problems associated with aging and are accepted and used. This work faces the challenge of improving the early detection of diseases like dementia, using an intelligent dialogue system that improves the chance for integrating applications of telemedicine in an intelligent home environment.
: Interest ring extraction around the optical disc for a robust retinal identification (2016)

International audience
High‐Throughput Automated Parallel Evaluation of Zinc‐Based Catalysts for the Copolymerization of CHO and CO<sub>2</sub> to Polycarbonates (2004)

Abstract Summary: Copolymerization of CO 2 and oxiranes using high‐pressure autoclaves typically allows one experiment per reactor per day. As a high‐throughput approach for this chemistry would be extremely valuable, a parallel setup has been validated for the copolymerization of CO 2 and cyclohexene oxide (CHO) with two β ‐diiminato zinc complexes. Molecular weights, polydispersities and activities were found to be comparable with literature values. Polycarbonate from cyclohexene oxide (CHO) and CO 2 . magnified image Polycarbonate from cyclohexene oxide (CHO) and CO 2 .
EBER1 - Oncogenic in Vivo? (2006)

Transfection of the EBERs into Epstein-Barr virus negative Akata cells, which were shown to lose the malignant phenotype and resistance to apoptosis present in EBV positive Akata cells, restored these properties. Thus suggesting an oncogenic role of the EBERs in Burkitt’s lymphoma cells and therefore indicating their possible contribution to the disease process of EBV-associated tumours (Komano et al., 1999). Furthermore, Yajima et al., (2005) have recently reported that the EBERs contribute to the transformation process of EBV in primary B cells. \n\nIn order to investigate the action of EBER1 as a potential oncogenic RNA, we have generated 13 lines of transgenic mice designed to express EBER1 in lymphoid cells. The transgenes incorporate a novel combination of tissue-specific RNA polymerase II and polymerase III elements and their expression was first confirmed in culture. \n\nMice of 10 of the transgenic lines have been shown to express EBER1 with specificity towards lymphoid tissues. Mice expressing EBER1 are viable. The phenotypic consequences of EBER1 expression in vivo is being examined and lymphoid expansion in mice of several lines has been observed at a young age as well as the development of B-cell lymphoma in one of the lines to date. The role of EBER1 in response to dsRNA stimulation in vivo is under study. Cross-breeding programmes were undertaken which revealed cooperation in B-cell lymphomagenesis between EBER1 and N-myc although this was not evident with the highly tumourigenic c-Myc line. This might suggest that the oncogenic predisposition in the EBER mice is elicited through a cell survival mechanism.\n\nThe results in this study support the hypothesis that EBER1 has oncogenic properties, the first polymerase III RNA described as such. Thus implicating the RNA in the pathogenesis of EBV associated lymphoma in addition to, or possibly as a consequence of, its role in immune evasion.
Corneal Contact Lenses: Large or Small? (1966)

A few years ago, the fitting of corneal lenses seemed a simple procedure. The contact lens diameter and peripheral curves were largely standardized. Although the fitting manuals of the various manufacturers did permit a small degree of flexibility in choosing the diameter, this was dictated by the width of the palpebral fissure and diameter of the cornea and pupil. The only parameters of a contact lens that varied were the central posterior curve and power, and these were determined by the "K" measurements and spectacle prescription. The conversion of the above measurements to a contact lens design required no more than one minute. If this was too great a burden for the busy practitioner, the manufacturers would gladly design the lens for him. Contact lens fitting by mail seemed an appropriate product of this remarkable era of computerized technology. However pleased the practitioners and contact lens manufacturers may have been,