gebhart/patrepeval huggingface dataset:
Fungal Sinusitis in Healthy and Immunocompromised Individuals (1984)

Clinical and microbiologic aspects of fungal sinusitis occurring in six patients are presented. Three of the six patients were immunosuppressed. Fatal disseminated fungal disease developed in two of those immunosuppressed. The three patients with normal immune function had fungal infections confined to the nasal sinuses. Aspergillus fumigatus and Aspergillus flavus were recovered from the immunosuppressed patients and Sporothrix schenckii, Alternaria species, and Pseudallescheria boydii were recovered from the immunocompetent patients. Surgical debridement was performed on all patients; however, anti-fungal therapy only was prescribed in patients who were at risk of progressive fungal disease. The microbiology laboratory aids in the diagnosis of fungal sinusitis by examining surgical biopsy material for fungal organisms and by culturing the material for recovery of the fungal pathogen.
Protein O-GlcNAc Modulates Motility-associated Signaling Intermediates in Neutrophils (2005)

The modification of serine/threonine residues on cytoplasmic and nuclear proteins by N-acetylglucosamine (O-GlcNAc) is suggested to play a role in the regulation of a variety of signal transduction pathways. We have previously shown that glucosamine (GlcNH(2)), a metabolic precursor of O-GlcNAcylation, increases (2)O-GlcNAc and enhances motility in neutrophils. Here, we extend this correlation by showing that a mechanistically distinct means of increasing O-GlcNAc, achieved by inhibition of O-GlcNAc removal with O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), increases basal cellular motility and directional migration induced by the chemoattractant formyl-methionine-leucine-phenylalanine (fMLP). Furthermore, we demonstrate that O-GlcNAc modulates the activities of signaling intermediates known to regulate neutrophil movement. GlcNH(2) and PUGNAc increase both the basal and fMLP-induced activity of a central mediator of cellular motility, the small GTPase Rac. Phosphoinositide 3-kinase, an important regulator of Rac activity and neutrophil motility, is shown to regulate the signaling pathway on which GlcNH(2) and PUGNAc act. Rac is an important upstream regulatory element in p38 and p44/42 mitogen-activated protein kinase (MAPK) signaling in neutrophils, and these MAPKs are implicated in chemotactic signal transduction. We show that GlcNH(2) and PUGNAc treatment increases p42/44 and p38 MAPK activities and that these increases are associated with activation of upstream MAPK kinases. These data indicate that O-GlcNAcylation is an important signaling element in neutrophils that modulates the activities of several critical signaling intermediates involved in the regulation of cellular movement.
High-Performance Concrete Mixture Proportioning (1998)

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Real-time detection of formaldehyde using PPLN-based mid-infrared laser for study of sick house syndrome (2015)

We studied the detection of formaldehyde using a compact 3-μm DFG light source based on a PPLN waveguide. Single-pass DFG of laser diodes enables wavelength modulation spectroscopy and real-time detection.
A symmetric miniature 3D inductor (2003)

A new 3D symmetric inductor structure is presented. It is shown that inductors driven with differential rather than single-ended signals give better performance. The proposed inductor is advantageous due to its inherent geometrical symmetry, and it retains Q and f/sub sr/ values that are comparable to its unsymmetrical 3D counterpart.
Benzodiazepine mediated antagonism of opioid analgesia (1997)

Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioids administered postoperatively. If so, then administration of the benzodiazepine antagonist flumazenil should enhance postoperative morphine analgesia. In a double-blind, placebo-controlled study of patients who received a preoperatively administered benzodiazepine (diazepam) for sedation and a postoperatively administered opioid (morphine) for analgesia, we investigated opioid-benzodiazepine interactions affecting postoperative dental pain. We found that flumazenil significantly enhanced morphine analgesia consistent with the hypothesis that the preoperatively administered benzodiazepine exerts an ongoing antianalgesic effect. In addition, we followed these patients over the first and second postoperative days to determine if there were differences between the drug groups in post-discharge pain, analgesic consumption, or side-effects. Participants receiving flumazenil reported significantly less post-discharge nausea and used significantly less ibuprofen. Since post-discharge pain levels were not significantly different, these results suggest that the patients receiving flumazenil required less analgesic medication to achieve a comparable level of pain control. In summary, our results indicate that the benzodiazepine antagonist flumazenil enhances morphine analgesia and decreases post-discharge side-effects as well as post-discharge need for analgesic medication.
ChemInform Abstract: REAKTION VON 1‐BROM‐3,4‐DIMETHYL‐PHOSPHOLEN‐(3) MIT KONJUGIERTEN DIENEN (1975)

Abstract Das Phospholen (I) reagiert mit Dimethylbutadien (II) (analog auch mit Butadien und Isopren) unter Bildung einer weißen, extrem hygroskopischen und in den für eine NMR‐Untersuchung geeigneten Lösungsmitteln unlöslichen Verbindung, die bei der Hydrolyse als Hauptprodukte je nach den Reaktionsbedingungen das Phospholenoxid (IV) [daneben (V)] oder, bei Vermeidung eines stark basischen Reaktionsmilieus, das Salz (IIIa) (daneben (IIIb)) gibt.
Optical design choices for VCSEL-based free-space optical interconnects (2003)

We introduce a model for a clustered free-space optical interconnect and use this to determine the maximum array density which can be achieved, together with the optimal cluster lens size which maximizes this density. We assume that the sources are multimode vertical cavity surface emitting lasers and that refractive microlenses are used to collimate the VCSEL beams. We also assume that the relay lenses are diffractive lenses with a quadratic phase profile. We find that for short interconnect distances, the maximum channel density is limited by the speed of the relay lenses, but that as the interconnect distance increases, geometric aberrations become the limiting factor. We also determine the interconnect distance below which a micro-channel relay is more suitable and the distance above which a single lens solution is adequate.
University researchers collaborate with Virginia Department of Emergency Management to develop statewide hazard mitigation plan (2009)

Floods, wild fires, hurricanes, and tornadoes are just a few examples of natural phenomena that cost the state millions of dollars in property and infrastructure damage. National, state, and local agencies are working with Virginia's Department of Emergency Management (VDEM) and researchers at the Virginia Tech Center for Geospatial Information Technology (CGIT) to develop part of a revised statewide plan for communities to identify these risks, vulnerabilities, and estimate potential losses.
Pharmacokinetic evaluation of sildenafil as a pulmonary hypertension treatment (2013)

In the last few years, considerable progress has been made in the understanding and treatment of PAH. Sildenafil citrate has multiple advantages and whether it is first-line treatment alone or in combination for the mild form of the disease, it is one of the treatments of choice. In terms of its future use, more studies are still needed to better evaluate the benefit/risk balance of sildenafil citrate in pediatric populations.
A new model of haze generation and storage-life-time estimation for mask (2006)

After quartz blanks with various sulfate ion amount on the surfaces were exposed by an ArF laser, growing defects, haze, on the surfaces were consequently counted by an inspection tool. As a result, the number of haze largely depends on the sulfate ion amount, and it is found that no haze is generated when the sulfate ion amount is smaller than a threshold value. A new haze generation model is provided to explain the threshold phenomenon. And then storage impact on increase of the sulfate ion amount was investigated. The sulfate ion amount increases with storage time and airborne SO<sub>x</sub> concentration. From the results, the adsorption coefficient of an extended Langmuir equation was calculated, and the adsorption phenomenon was analyzed in detail. Simulation results show that it is recommended, regarding for storage environment, to keep under 0.01 ppbv airborne SO<sub>x</sub> concentration in order to prevent haze for one year.
Variational message-passing: extension to continuous variables and applications in multi-target tracking (2013)

This dissertation focuses on both the application and development of variational inference algorithms for probabilistic graphical models. First, we propose a new application of graphical models and approximate inference in the multi-target tracking domain. By constructing a factor graph representation of the track-oriented multiple hypothesis tracker, we enable the application of variational inference algorithms to efficiently estimate marginal probabilities of possible tracks. We then show that these track marginals are the key ingredient in a multi-target generalization of the standard expectation-maximization algorithm used for parameter estimation in single-target tracking. The resulting online estimation algorithm makes the tracker robust to parameter misspecification and can improve performance in settings with non-stationary target dynamics. Next, we develop a general framework to extend algorithms for approximate marginalization in discrete systems to work with continuous-valued graphical models. We extend the particle belief propagation algorithm, which uses importance sampling to lift the sum and product operations of belief propagation from a variable's continuous domain into an importance-reweighted particle domain. We demonstrate that this framework admits other variational inference algorithms such as mean field and tree-reweighted belief propagation, and that they confer similar qualitative benefits to continuous-valued models as in the discrete domain.
Smoking and survival after breast cancer diagnosis in Japanese women: A prospective cohort study (2015)

The results of previous studies investigating whether there is an association between active smoking and risk of death among breast cancer patients have been inconsistent. We investigated the association between active and passive smoking and risk of all-cause and breast cancer-specific death among female breast cancer patients in relation to menopausal and tumor estrogen/progesterone receptor (ER/PR) status. The present study included 848 patients admitted to a single hospital in Japan from 1997 to 2007. Active or passive smoking status was assessed using a self-administered questionnaire. The patients were followed until 31 December 2010. We used a Cox proportional-hazard model to estimate hazard ratios (HR). During a median follow-up period of 6.7 years, 170 all-cause and 132 breast cancer-specific deaths were observed. Among premenopausal patients, current smokers showed a non-significant higher risk of all-cause and breast cancer-specific death. A duration of smoking >21.5 years was positively associated with all-cause (HR = 3.09, 95% confidence interval [CI], 1.17-8.20) and breast cancer-specific death (HR = 3.35, 95% CI: 1.22-9.23, Ptrend = 0.035) among premenopausal patients. In premenopausal patients with ER+ or PR+ tumors, there was some suggestion that a longer duration of smoking was associated with higher risk of all-cause and breast cancer-specific death. Passive smoking demonstrated no significant risk. Our results suggest that a longer duration of active smoking is associated with an increased risk of all-cause and breast cancer-specific death among premenopausal patients, possibly with hormonal receptor-positive tumors. Breast cancer patients should be informed about the importance of smoking cessation.
Detection, Identification and Molecular Characterization of a Phytoplasma Associated with Arabian Jasmine (<i>Jasminum sambac</i> L.) Witches’ Broom in Oman (2007)

Abstract Arabian jasmine ( Jasminum sambac L.) plants showing witches’ broom (WB) symptoms were found in two regions in the Sultanate of Oman. Polymerase chain reaction (PCR) amplification of the 16S rRNA gene and the 16S–23S spacer region utilizing phytoplasma‐specific universal and designed primer pairs, and transmission electron microscopy of phytoplasma‐like structures in phloem elements confirmed phytoplasma infection in the symptomatic plants. PCR products primed with the P1/P7 primer pair were 1804 bp for jasmine witches’ broom (JasWB) and 1805 bp for alfalfa ( Medicago sativa L.) witches’ broom (AlfWB). Actual and putative restriction fragment length polymorphic analysis indicated that jasmine and AlfWB phytoplasmas were molecularly indistinguishable from each other and closely related to papaya yellow crinkle (PYC), as well as being distinct from lime WB (LWB) and Omani alfalfa WB (OmAlfWB) phytoplasmas. A sequence homology search of JasWB and AlfWB showed 99.8% similarity with PYC from New Zealand and 99.6% similarity with each other (JasWB/AlfWB). The jasmine and AlfWB phytoplasmas were also shown to be related to the peanut WB group (16SrII) of 16S rRNA groups based on a phylogenetic tree generated from phytoplasma strains primed with the P1/P7 primer pair and representing the 15 phytoplasma groups.
Near-infrared autofluorescence for the detection of parathyroid glands (2011)

A major challenge in endocrine surgery is the intraoperative detection of parathyroid glands during both thyroidectomies and parathyroidectomies. Current localization techniques such as ultrasound and sestamibi scan are mostly preoperative and rely on an abnormal parathyroid for its detection. In this paper, we present near-infrared (NIR) autofluorescence as a nonintrusive, real-time, automated in vivo method for the detection of the parathyroid gland. A pilot in vivo study was conducted to assess the ability of NIR fluorescence to identify parathyroid glands during thyroid and parathyroidectomies. Fluorescence measurements at 785 nm excitation were obtained intra-operatively from the different tissues exposed in the neck region in 21 patients undergoing endocrine surgery. The fluorescence intensity of the parathyroid gland was found to be consistently greater than that of the thyroid and all other tissues in the neck of all patients. In particular, parathyroid fluorescence was two to eleven times higher than that of the thyroid tissues with peak fluorescence occurring at 820 to 830 nm. These results indicate that NIR fluorescence has the potential to be an excellent optical tool to locate parathyroid tissue during surgery.
A diet enriched with fish, vegetables, and fruits worsened cognitive function and neuroinflammatory gene expression in a transgenic mouse model of Alzheimer's disease (2012)

Consumption of fish, fruits and vegetables are associated with lower incidence of Alzheimer's disease (AD). We hypothesized that a similar dietary profile would improve cognitive function in a transgenic mouse model of AD. Groups of TgCRND8 mice, and their wildtype littermates, received a standard rodent diet or the standard diet enriched with freeze‐dried salmon, vegetables, and fruits over four months. During the last month of feeding, cognitive function was assessed by a comprehensive battery of tasks adapted to the Morris water maze. Transgenic animals were impaired on all cognitive tests compared to their wildtype littermates. Unexpectedly, a ‘Diet x Transgene’ interaction was observed in which transgenic animals fed the enriched diet exhibited even worse cognitive function than their transgenic counterparts fed the control diet on tests of spatial memory (P<0.01), cued memory (P<0.01), and strategic rule learning (P=0.038) that collectively indicated damage to the hippocampus and frontal lobes. These cognitive deficits coincided with higher hippocampal gene expression of tumor necrosis factor‐alpha (P=0.013). These results indicate that a dietary profile identified by epidemiological studies exacerbated cognitive dysfunction in a mouse model of familial AD possibly by enhancing neuroinflammation through an impaired hormetic response. (CIHR)
Optimal spatial resolution in vision-based inspetion of pipes using Catadioptric sensors (2012)

Spatial resolution of imaging systems plays a major role in the design of vision-based industrial inspection systems. In this paper we formulate the cylindrical spatial resolution of a Catadioptric sensor that consists of a camera and a hyperbolic mirror for the pipe inspection applications based on the projection models cited in the literature. A laser ring is used as a structured light source for illumination. Also we provide a guideline for selecting the optimal configuration setup, subjected to the changes in the focal length of the perspective pin-hole camera and also the shape of the hyperbolic mirror, that yields highest inspection resolution.
Effect of High Hydrostatic Pressure on the Volatile Components of a Glucose−Lysine Model System (1999)

An aqueous glucose-lysine model system (initial pH 10.1) was incubated at 60 degrees C and atmospheric pressure (system A) or 600 MPa (system B) to the same absorbance value at 420 nm. Volatile reaction products were isolated by solvent extraction and analyzed by gas chromatography/mass spectrometry. Thirty-two compounds were identified; most contained nitrogen, and pyrazines predominated. Yields of all compounds were suppressed at 600 MPa. Further incubation, at either atmospheric pressure (system C) or 600 MPa (system D), of system A, resulted in lower yields of many compounds at 600 MPa, compared to prolonged incubation at atmospheric pressure. Many of the compounds reported may be formed by, or subsequently react via, aldol condensation. The observed differences among the systems in the profiles and yields of volatile compounds suggest that aldol condensations increase in rate in the systems under pressure.
Pathomorphological findings of a prenatally diagnosed thanatophoric dwarf. (1982)

A case of prenatally diagnosed thanatophoric dysplasia is presented. Other syndromes accompanied by chondrodysplastic tetramicromelia were excluded and diagnosis was based on the narrow thorax, secondary pulmonary hypoplasia and macrocephaly detected by ultrasound and on radiological findings of disturbances of bone formation. At the mother's request labour was induced and radiological, anatomic and histological examination of the newborn confirmed the prenatal diagnosis. By electron microscopy, large conspicuous, homogeneous intracytoplasmic, usually single vacuoles were found in virtually every chondrocyte. Attention is focused on the significant hydramnion which led to the suspicion of fetal malformation. The importance of routine ultrasound screening in pregnancy is emphasised, since such malformations can be detected as early as the midtrimester pregnancy. The use of such methods ensures better maternal care.
Coma-free Alignment Using Diffractograms of TV Images (1995)

Journal Article Coma-free Alignment Using Diffractograms of TV Images Get access Kazuo Ishizuka Kazuo Ishizuka Electron Wavefront Project, JRDCc/o Toyo University, Kawagoe, 350 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Electron Microscopy, Volume 44, Issue 3, June 1995, Pages 154–158, https://doi.org/10.1093/oxfordjournals.jmicro.a051164 Published: 01 June 1995 Article history Received: 09 February 1995 Accepted: 14 April 1995 Published: 01 June 1995
Colorimetric determination of potassium in plasma and serum by reflectance photometry with a dry-chemistry reagent. (1992)

We evaluated a colorimetric assay of potassium in plasma and serum with the Boehringer Mannheim Reflotron reflectance photometric analyzer, which is designed for near-patient testing in hospitals and physicians' offices. This potassium method does not require calibration or instrument maintenance by the operator. Analysis of 30 microL of plasma or serum takes approximately 140 s. Within-day imprecision (CV) was 1.0-1.2%. Total CVs over a 1-month period were 1.0-1.4%. Patients' results from the Reflotron correlated well with those from the IL 643 flame photometer and the Beckman Synchron CX3 ion-selective electrode methods. The accuracy of Reflotron values was also verified with Standard Reference Material 956 from the National Institute of Standards and Technology.
Satisfactory War-Time Rations for Pheasant Chicks (1944)

demische Verlags Gesellschaft, p. 410. 29. NELSON, E. W. 1881. Habits of the black brant in the vicinity of St. Michaels, Alaska. Nuttall Ornith. Club Bull., 6: 131-138. 30. 1883. Cruise of the Corwin in Alaska and the Northwest Arctic Ocean in 1881. Washington, D. C., Government Printing Office, pp. 94-95. 31. 1887. Report upon natural history collection made in Alaska between the years 1877 and 1881. Arctic Series of Publications, Signal Service, U. S. Army, Government Printing Office, Washington, D. C. 49th Cong. 1st Sess. Misc. Doc. 156, No. 3, pp. 87-89. 32. PETERS, J. L. 1931. Check-list of birds of the world. Cambridge, Mass., Harvard Univ. Press, 1: 149-150. 33. PHILLIPS, J. C. 1932. Fluctuation in numbers of the eastern brant goose. Auk, 49: 445-453. 34. SOPER, J. D. 1930. The blue goose. Ottawa, Canada. Dept. of Int., p. 40. 35. SUTTON, G. M. 1932. The exploration of Southampton Island, Hudson Bay. Carnegie Mus. Mem., 12, Pt. 2, Zool. Sect. 2-Birds of Southampton Island, pp. 41-44. 36. VAN DYKE, T. S. 1883. Hills and streams of southern California. American Field, 19: 226-227. 37. WITHERBY, H. F., et al. 1939. Handbook of British birds. London, H. F. & G. Witherby Ltd., 3: 214-215.
Excited State Processes in Linear π-System-Based Organogels (2010)

This article describes the recent progress made to the understanding of the excited state interactions in organogels derived from linear π-conjugated molecules. The soft organogel scaffolds of such systems create an excellent ambience for the self-organization of the molecules allowing the modulation of their excited state properties and thereby opening a new world of fascinating materials with interesting physical properties at nano- and macroscopic levels. Noncovalent interactions provide opportunity for the molecules to interact electronically within a space of defined size and shape. As a result, the photophysical properties of the molecules in solution and gel states are different from each other. In this perspective article we analyze the role of the self-assembled organogel scaffolds of π-gels derived from linear π-systems in modulating the excited state properties such as excited state energy transfer, exciplex emission, phosphorescence, and aggregation-induced enhanced emission (AIEE), when compared to the corresponding individual molecules.