gebhart/patrepeval huggingface dataset:
Sol-gel derived nanoparticles and processing routes to ceramics and composites (1998)

Highly crystalline nanoparticles from Y-Zr02 and FeOx have been prepared by microemulsion with subsequent solvothermal treatment and by precipitation processes. In both cases, aqueous based intermediates have been prepared which have been surface-modified by carboxylic acids and ammosilane. The surface modification prevents the formation of hard agglomerates of the nanoparticles (6-8 ran) completely and provides complete redispersibility. Low sintering compacts and nanocomposites have been prepared, and first results for using the FeOx nanoparticles for medical applications have been obtained.
Relationships between the developmental potential of human in-vitro fertilization embryos and features describing the embryo, oocyte and follicle (1998)

This paper investigates the relationship of features of in-vitro fertilization (IVF) embryos and the associated oocyte and follicle to the outcome of transfer. It differs from previous studies in including a range of features (n = 53) and in using class probability tree analysis. This is a non-parametric multivariate method which expresses relationships as simple rules of features characterizing the 'take home baby' and 'no take home baby' (negative pregnancy test) classes of embryo batches. Data were analysed retrospectively. Fifty-three (embryo, oocyte and follicular) features for each of the three embryos in the transferred batch were collected for 200 IVF patients. Each batch of three embryos was described by a representative value for each feature. The relationship between features and outcome of transfer was analysed. Only four of the 53 features were identified as predictive. However, an appropriate combination of these four (embryo grade, cell number, follicle size and follicular fluid volume) achieved satisfactory predictivities while offering a simplified and more quantitative basis than regularly used criteria. The key component of the composite embryo grading allotted by embryologists turned out to be cell number. The existing predictive use of follicular size was corroborated and an independent additional predictive contribution of follicular fluid volume was found. The study also suggests that the 49 remaining features have little additional predictive value.
New generation of RF unit for radar altimeter (2001)

Alcatel developed a new generation of dual-frequency radar altimeter (POSEIDON 2) which works in C and Ku band. This article discusses about the radiofrequency unit (RFU) which plays a major role for the stringent performances of the altimeter. The compact RF unit has been designed with a modular concept. It uses the new advanced technologies: extensively use of MMIC, pHemt LNA and hybrid HFET power amplifiers. The transmitted peak power level is greater than 23W in C band and 7W in Ku band.
Gallstones in critically ill patients with acute calculous cholecystitis treated by percutaneous cholecystostomy: nonsurgical therapeutic options. (1994)

Nonsurgical gallstone therapies should be attempted in high-risk patients with acute calculous cholecystitis. Some patients may benefit from long-term catheter drainage of the gallbladder.
Silicon Web process development. Low Cost Solar Array Project, Large Area Silicon Sheet Task. Third quarterly report, October 1, 1977--December 31, 1977 (1977)

The experimental phase of the program was oriented toward developing growth configurations which produced crystals having low residual stress levels. It was found that some slot designs, especially thick lids with narrow slots tended to produce crystals with high residual stress, however these lids also were conducive to melts with minimal temperature fluctuations and relatively flat temperature profiles. Several runs were also made to evaluate the properties of a 106 mm diameter round crucible which in principle should have a superior thermal profile. Thermal modeling efforts were directed to developing finite element models of both the 106 mm round crucible and an elongated susceptor/crucible configuration for the new furnace system. The model for the larger round crucible was completed and predicted a very satisfactory temperature distribution. Additionally, the separate thermal model for the heat loss modes from the dendritic web itself was examined for guidance in reducing the thermal stress in the web. An economic analysis has been prepared in order to evaluate the silicon web process present and expected future status as related to the 1982 and 1986 price goals.
Relationships between Transient Myocardial Ischemia, Pain and Ventricular Tachyarrhythmias (1989)

In order to study the factors eliciting pain related to transient ischemic episodes, out of 75 patients with Prinzmetal angina admitted to our institution in the last 5 years, we selected 40 patients according to the following criteria: (1) presence of at least one ischemic episode during 24 h ECG ambulatory monitoring, and (2) absence of cardiologic therapy except nitrates when needed. During 76 days of ambulatory ECG monitoring, the patients presented 2,052 transient ischemic episodes, 579 (28%) were symptomatic. Painful episodes were longer than painless ones (4.70 ± 2.86 vs. 3.10 ± 194 min, p < 0.01), had a longer 'ischemic phase' duration (2.50 ± 1.85 vs. 1.60 ± 1.12 min, p < 0.01) and had a greater ST-segment shift (0.28 ± 0.19 vs. 0.15 ± 0.16 mV, p < 0.01). Of 2,052 ischemic episodes, 1,514 showed ST-segment elevation, 15 ST-segment depression, 324 pseudonormalization of a negative T wave and 199 T wave peaking; painful episodes were 35, 33, 11 and 6%, respectively. Of all the episodes, 1,722 did not present any arrhythmia within the ischemic episode (23% symptomatic), 154 premature ventricular contractions (40% symptomatic) and 176 bigeminy or ventricular tachycardia (68% symptomatic). Moreover, given the same duration of ischemia and the same level of ST-segment shift, ischemic episodes were significantly (p < 0.001) more symptomatic when arrhythmias were present. As to time of occurrence, painless episodes showed a circadian rhythmicity with a maximum during the nighttime at 2 a.m.; painful ones were more concentrated during the daytime with a maximum at 6 a.m. Only painless ischemic episodes showed a circadian rhythm. In conclusion, in patients with Prinzmetal angina only a minority of ischemic episodes are painful, the occurrence of pain is greatly influenced by different temporal occurrence during the daytime and by the simultaneous occurrence of arrhythmias within the ischemic episodes.
Retraction: Reliability and Validity of the Korean Cancer Pain Assessment Tool (KCPAT) (2006)

The above article became to belatedly recognized by the editor of Journal of Korean Medical Science (JKMS) having almost same contents with an article which appeared in Korean Journal of Hospice and Palliative Care (=Hankook Hospice Wanhuaeuiryohakhoeji in Korean) 2003;6:152-63, entitled, Reliability and Validity of the Evaluation of Korean Cancer Pain Assessment Tool (K-CPAT). The 2003 article was written in Korean language, and authored by Youn Seon Choi, June young Lee, Jin No Park, Myung Ah Lee, Chang Hwan Yeom and Se Kwon Jang (with corresponding author Dr. J. Lee). Both articles shared same contents of four tables, appendix and message.
Persimmon Oligomeric Proanthocyanidins Extend Life Span of Senescence-Accelerated Mice (2009)

The anti-aging activities of persimmon oligomeric proanthocyanidins (POPs), reported to improve life span and behavioral characteristics associated with the aging process, were investigated using the senescence-accelerated mouse (SAM) P8, which is a good model for studies on aging-related behavioral changes as well as life span. We demonstrated that the administration of POPs extended the life span of SAMP8. In addition, POPs elevated Sirt1 expression, which is recognized as an essential factor for life span extension in the brain. On the other hand, the administration of POPs did not induce stereotypical behaviors such as rearing, jumping, and hanging from the lid of a cage, whereas food restriction increased these frequencies without a significant change in motor function. The present study suggests a promising role of POPs as anti-aging agents to extend life span, although further studies elucidating their anti-aging mechanisms acting are needed.
ALTERATIONS OF BRAIN CEREBRAL CORTEX CCK RECEPTORS IN THE OB/OB MOUSE<sup>1</sup> (1981)

We investigated the binding of CCK to its receptors in the brain and pancreas of the ob/ob mouse, an animal model of inherited obesity. The binding of CCK to its receptors in the cerebral cortex was increased, and Scatchard analyses revealed that this increased binding was due to an increase in the number of receptor sites. By contrast, there was no increased binding to CCK receptors in other brain regions, including the hypothalamus, or to CCK receptors in the pancreas. In the db/db mouse, another animal model of inherited obesity, no changes in CCK binding to its receptors in cerebral cortex and other brain regions were detected. Our study demonstrates, therefore, that the ob/ob mouse has changes in brain CCK receptors and suggests that certain types of obesity in mice could be related to altered CCK binding and action.
Effects of partial-spectrum filtering on DOP monitoring for PMD compensation (2004)

We investigated the effects of all-order PMD on the DOP monitoring technique based on partial-spectrum filtering for 10-Gb/s NRZ signal. The results showed that the partial-spectrum filtering could not improve the performance of PMD compensation.
On Parity-Preserving Constrained Coding (2018)

Necessary and sufficient conditions are presented for the existence of fixed-rate parity-preserving encoders for a given constraint. It is also shown that under somewhat stronger conditions, the stethering method guarantees an encoder that has finite anticipation.
<title>Evaluation of time-frequency filtering for SAR/ISAR motion compensation via instantaneous frequency estimators</title> (1996)

In previous work, the authors have proposed the compensation of translational motion of an object via time-frequency filtering in a way that separation of scatterers can be done and compensation can be achieved selectively. In this paper, the effect of filtering in the time-frequency domain is studied focusing on the effects that this processing introduces to the phase of the scatterer response. The instantaneous frequency associated with one scatterer in the image is estimated and compared to the estimated frequency obtained for the case where only that scatterer is present by itself. Deviations caused by these two computations are presumed to affect the final compensation of an image regardless of which compensation technique is used.
ChemInform Abstract: Transmembrane Electron Transfer as Catalyzed by Poly(ethyleneimine)‐Linked Manganese Porphyrins. (1987)

Abstract Poly(ethyleneimine)‐linked Mn porphyrins such as (I) associate with phospholipid bilayers in a manner that allows the porphyrin to penetrate the membrane to a depth limited by the hydrocarbon spacer (number of CH 2 units between the amide bonds) linking it to the extremely hydrophilic polymer.
Selective Reductions. I. The Partial Reduction of Tertiary Amides with Lithium Aluminum Hydride. A New Aldehyde Synthesis via the 1-Acylaziridines<sup>1,2</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective Reductions. I. The Partial Reduction of Tertiary Amides with Lithium Aluminum Hydride. A New Aldehyde Synthesis via the 1-Acylaziridines1,2Herbert C. Brown and Akira TsukamotoCite this: J. Am. Chem. Soc. 1961, 83, 22, 4549–4552Publication Date (Print):November 1, 1961Publication History Published online1 May 2002Published inissue 1 November 1961https://pubs.acs.org/doi/10.1021/ja01483a013https://doi.org/10.1021/ja01483a013research-articleACS PublicationsRequest reuse permissionsArticle Views659Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Peptide sequence determination by matrix-assisted laser desorption ionization employing a tandem double focusing magnetic—Orthogonal acceleration time-of-flight mass spectrometer (1996)

This report describes the fragmentation processes for peptides induced by collisional activation of the (12)C isobar of matrix-assisted laser desorption ionization (MALDI)-generated pseudomolecular ions employing an EBE orthogonal acceleration time-of-flight mass spectrometer and using xenon as the collision gas at a laboratory collision energy of 800 eV. These MALDI-collision-induced dissociation (CID) spectra are shown to provide sequence information of comparable quality to those obtained by using high energy CID conditions with liquid secondary ionization mass spectrometry on a four-sector tandem instrument. Peptide sequencing via MALDI-CID is demonstrated on three tryptic peptides obtained from a bacterial protein (P450 isozyme) of unknown sequence. Sensitivity is shown to be at the 1 pmol level for standard peptides.
Differential Localization of G Protein βγ Subunits (2014)

G protein βγ subunits play essential roles in regulating cellular signaling cascades, yet little is known about their distribution in tissues or their subcellular localization. While previous studies have suggested specific isoforms may exhibit a wide range of distributions throughout the central nervous system, a thorough investigation of the expression patterns of both Gβ and Gγ isoforms within subcellular fractions has not been conducted. To address this, we applied a targeted proteomics approach known as multiple-reaction monitoring to analyze localization patterns of Gβ and Gγ isoforms in pre- and postsynaptic fractions isolated from cortex, cerebellum, hippocampus, and striatum. Particular Gβ and Gγ subunits were found to exhibit distinct regional and subcellular localization patterns throughout the brain. Significant differences in subcellular localization between pre- and postsynaptic fractions were observed within the striatum for most Gβ and Gγ isoforms, while others exhibited completely unique expression patterns in all four brain regions examined. Such differences are a prerequisite for understanding roles of individual subunits in regulating specific signaling pathways throughout the central nervous system.
XXVI. A Bed of Post-glacial Clay, exposed by Dredging in the Harbour of Girvan, Ayrshire (1885)

General Description of the Girvan District. —This district lies nearly at the southern angle of the Ayrshire triangle, and is classic from the fossiliferous character of its Silurian strata. There are few districts in Scotland in which, within short distances, the geologist can enjoy such opportunities of studying different strata, and of practically testing so many interesting geological theories. To the south-east and east there is a large Silurian area that constitutes a part of the great tract forming the southern ridge, or axis of elevation across Scotland from S.W. to N.E. To the north-west of the Girvan Valley lies a smaller area of Silurian strata, yet including the famous Mulloch Hill, Drummuck Burn, Threave Glen, and Craighead Quarry. Between these two tracts lies the beautiful valley of the Girvan, which is composed of Carboniferous strata to within a mile or two of the town of Girvan. Three patches of Old Red Sandstone occur in the immediate vicinity—one to the south of the town, one on which the town is built, and one further north, where, near the shore, an old quarry still is occasionally worked. The last two are no doubt continuous, although the union is hidden by the diluvium of the valley. Glacial Phenomena. —The shore to the north of the river is strewn with boulders, many that lay on the south shore having been utilized for housebuilding. In dredging near the shore it is found that a fringe of boulders extends below low water-mark. The majority of these boulders This 250-word extract was created in the absence of an abstract
Feasibility Study for the Development and Marketing of Magnesium Seats for Motor Coaches and Other Modes of Public Transit (2004)

This study was conducted to dispel doubts about the use of magnesium to manufacture lighter weight seats for the public transit industry, particularly the motor coach industry. The introduction provides background on the study methodology and on the benefits of lower weight components in road vehicles. Part 2 is an overview of the public transit industry, including major industry players and changes that have occurred in transit vehicle markets. It also contains an overview of the passenger seat market and profiles of the principal seat manufacturers, and concludes with descriptions of current applications of magnesium seats. Part 3 examines major technological and economic issues related to magnesium seats, such as design standards, testing, properties of magnesium alloys, and costs. Part 4 outlines how the results of a case analysis were used to determine the technical and economic feasibility of small- and large-scale manufacturing of a new magnesium seat for the motor coach market. The final part summarizes the facts about magnesium seats and their viability, and makes recommendations with regard to the market potential of lighter weight seats.
Abstract 1039: Histone deacetylase 8 (HDAC8) target identification and mechanism of action of HDAC8 isoform-specific inhibitors (2012)

Abstract HDAC8 is a member of the histone deacetylase family, but no acetylation target in cells has yet been identified. Due to a different pocket structure, most of the pan-HDAC inhibitors currently in the clinic bind poorly to it. HDAC8 knockout mice were shown to have an embryonic defect in neural crest development, but the adult mice have no other published phenotype, and its functions in adult normal or tumor cells are not well understood. In this work, we have undertaken extensive cellular and tissue localization studies, knockdown and isoform-specific inhibition studies, whole genome expression profiling, proteomics experiments to identify differentially acetylated and expressed proteins, and kinome siRNA knockdown experiments to identify pathways of activity. In total, these results point to HDAC8's essential function in many tumor cell types, not all of which are dependent upon the enzymatic activity of the enzyme. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1039. doi:1538-7445.AM2012-1039
Abstract 311: Nifedipine Attenuates Abdominal Aortic Aneurysm in Ang II-infused hph-1 Mice (2013)

We have previously shown that angiotensin II (Ang II) perfusion of hph-1 mice results in development of severe abdominal aortic aneurysm (AAA, 79% within 2 wks) that is associated sudden death and regulation of blood pressure. This phenotype can be completely attenuated by recoupling of eNOS with oral folic acid (FA) administration, which restores eNOS cofactor tetrahydrobiopterin (H4B) bioavailability via restoration of endothelial H4B salvage enzyme dihydrofolate reductase (DHFR). In view of the unclear relationship between blood pressure and AAA formation, we investigated the potential effects of L-type calcium channel blocker (CCB) Nifedipine (Nif) on AAA formation using the Ang II infused hph-1 model. Six-month old hph-1 mice were infused with Ang II (0.7 mg/kg/day) for 2 wks using Alzet osmotic pumps. The animals were fed Nif chew (20 mg/kg/day) two days prior to Ang II infusion and throughout the study period of 2 wks. Of note, the incidence rate of AAA dropped from 79% to 21% (2 out of 13). The Ang II induced hypertension (telemetry) and expansion of abdominal aorta (ultrasound) in hph-1 mice were abolished by Nif diet. Increased aortic reactive oxygen species (ROS) production (DHE) was also attenuated by Nif administration. L-NAME sensitive superoxide production, reflective of eNOS uncoupling activity, was measured by electron spin resonance (ESR). Treatment with Nif restored eNOS function completely, resulting in -2.49± 0.71 fold change in L-NAME sensitive superoxide production. Our previous data demonstrated extensive eNOS uncoupling activity (>10 fold) in Ang II-infused hph-1 mice that is attenuated by restoration of endothelial DHFR function (Hypertension 2012). Nif treatment also markedly improved NO bioavailability (ESR) by 2.42± 0.23 fold. These data demonstrate that an oral treatment of Nif is effective in correcting eNOS dysfunction to attenuate AAA formation. Although it does not differentiate the contributions from attenuation of oxidative stress and blood pressure lowering, it once again suggests that eNOS uncoupling can an important mediator of AAA formation.
Role of leptin in early metabolic programming (2009)

Experimental studies in rodents have highlighted the relationship between early postnatal events, undernutrition during pregnancy and/or lactation and the subsequent development of metabolic syndrome, a phenomenon termed developmental programming. However, appearance of metabolic syndrome is dependent not only on prenatal or postnatal predisposition but also on type of nutrition throughout the life cycle. Those experimental findings have been supported by epidemiological data in humans, born to mothers who suffered undernutrition during pregnancy. Leptin is likely involved is such programming and maintaining a critical leptin level during development may allow normal maturation of tissues and pathways involved in metabolic homeostasis, reversing the undesired effects. Leptin disruption during a critical neonatal or prenatal window is sufficient to permanently alter long-term metabolic regulation. Thus, in rodents (in the early postnatal phase), and likely in other species such as primates, and including humans (in the prenatal period), leptin plays a major role in the development of brain circuits which affect future developmental programming of metabolic disease. As postnatal nutritional or therapeutic intervention can ameliorate the consequences of developmental malprogramming, use of leptin as an additive to milk in infant formula which, in contrast to maternal milk, which is devoid of this protein, has been suggested. Alternatively, identification of potential factors elevating leptin levels in maternal milk may also be beneficial. In conclusion, the present data highlight the importance of leptin in the developmental induction of metabolic disease and offer exciting new strategies for therapeutic intervention, by either maternal or neonatal intervention or targeted nutritional manipulation in postnatal life. Adipobiology 2009; 1: 27-34.