gebhart/patrepeval huggingface dataset:
Study on Citrus Response to Huanglongbing Highlights a Down-Regulation of Defense-Related Proteins in Lemon Plants Upon ‘Ca. Liberibacter asiaticus’ Infection (2013)

Citrus huanglongbing (HLB) is a highly destructive disease of citrus presumably caused by 'Candidatus Liberibacterasiaticus' (Las), a gram-negative, insect-transmitted, phloem-limited α-proteobacterium. Although almost all citrus plants are susceptible to HLB, reports have shown reduced susceptibility to Las infection in lemon (Citrus limon) plants. The aim of this study is to identify intra-species specific molecular mechanisms associated with Las-induced responses in lemon plants. To achieve this, comparative 2-DE and mass spectrometry, in addition to Inductively Coupled Plasma Spectroscopy (ICPS) analyses, were applied to investigate differences in protein accumulation and the concentrations of cationic elements in leaves of healthy and Las-infected lemon plants. Results showed a differential accumulation of 27 proteins, including an increase in accumulation of starch synthase but decrease in the production of photosynthesis-related proteins in Las-infected lemon plants compared to healthy plants. Furthermore, there was a 6% increase (P > 0.05) in K concentration in leaves of lemon plants upon Las infection, which support results from previous studies and might represent a common response pattern of citrus plants to Las infection. Interestingly, contrary to reports from prior studies, this study showed a general reduction in the production of defense-related pathogen-response proteins but a 128% increase in Zn concentration in lemon plants in response to Las infection. Taken together, this study sheds light on general and intra-species specific responses associated with the response of citrus plants to Las.
Minimising computational complexity of the RRT algorithm a practical approach (2011)

Sampling based techniques for robot motion planning have become more widespread during the last decade. The algorithms however, still struggle with for example narrow passages in the configuration space and suffer from high number of necessary samples, especially in higher dimensions. A widely used method is Rapidly-exploring Random Trees (RRT's). One problem with this method is the nearest neighbour search time, which grows significantly when adding a large number of vertices. We propose an algorithm which decreases the computation time, such that more vertices can be added in the same amount of time to generate better trajectories. The algorithm is based on subdividing the configuration space into boxes, where only specific boxes needs to be searched to find the nearest neighbour. It is shown that the computational complexity is lowered from a theoretical point of view. The result is an algorithm that can provide better trajectories within a given time period, or alternatively compute trajectories faster. In simulation the algorithm is verified for a simple RRT implementation and in a more specific case where a robot has to plan a path through a human inhabited environment.
<b>Amelia</b>II: A Program for Missing Data (2011)

Amelia II is a complete R package for multiple imputation of missing data. The package implements a new expectation-maximization with bootstrapping algorithm that works faster, with larger numbers of variables, and is far easier to use, than various Markov chain Monte Carlo approaches, but gives essentially the same answers. The program also improves imputation models by allowing researchers to put Bayesian priors on individual cell values, thereby including a great deal of potentially valuable and extensive information. It also includes features to accurately impute cross-sectional datasets, individual time series, or sets of time series for different cross-sections. A full set of graphical diagnostics are also available. The program is easy to use, and the simplicity of the algorithm makes it far more robust; both a simple command line and extensive graphical user interface are included.
Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models (2015)

Supplementary data are available at Bioinformatics online.
Scattering matrix subtraction technique for mode-matching analysis of substrate integrated waveguide junctions (2017)

A scattering matrix subtraction method is employed within the mode-matching technique (MMT) to model right-angle substrate integrated waveguide (SIW) junctions. The advantage of this approach lies in the fact that generalized scattering matrices of inline SIW waveguide circuits, including simple bi- and trifurcations are computed first. In a second step, the scattering matrices of regular waveguide corners are subtracted to yield the overall scattering matrices of right-angle SIW junctions. The method is demonstrated for a SIW corner with straight forward extension to T-junctions and cross junctions. Examples of a SIW corner filter, a SIW T-junction diplexer, a SIW cruciform hybrid and a SIW crossover demonstrate the validity of this technique.
I.—<i>Entomological Expedition to Abyssinia</i>, 1926–7. <i>Coleoptera</i>, Scarabæidæ (1940)

(1940). I.—Entomological expedition to Abyssinia, 1926–7. Coleoptera, Scarabaeidae. Annals and Magazine of Natural History: Vol. 6, No. 31, pp. 1-26.
Immunoenzymetric assay for creatine kinase MB with subunit-specific monoclonal antibodies compared with an immunochemical method and electrophoresis. (1985)

Results of an immunoenzymetric assay (TANDEM-E CKMB) for creatine kinase (CK; EC 2.7.3.2) MB isoenzyme, in which subunit-specific monoclonal antibodies are used, were compared with those by an immunochemical method (Isomune-CK) and electrophoresis (Corning agarose gel). The study involved 200 patients; greater than 500 samples were analyzed by all three methods. The analytical performances were acceptable. Between-method correlation coefficients ranged from 0.881 to 0.975. Two reference intervals were established for the immunoassays: 0-4 micrograms/L (TANDEM) and 0-4 U/L (Isomune) for "normal" patients; 0-9 micrograms/L (TANDEM) and 0-14 U/L (Isomune) for noninfarct patients. Agreement with respect to increased CK-MB as defined by the reference intervals for the noninfarct patient was 96% between TANDEM and electrophoresis, 90% between Isomune and electrophoresis. All three methods are acceptable for use in determining CK-MB, but the overall diagnostic efficiencies for the mass or activity concentration of the isoenzyme and for its proportion of total CK activity, based on the predictive value model, are 92% (electrophoresis, 0-7 U/L), 90% (electrophoresis, 0-4%), 92% (TANDEM, 0-9 micrograms/L), 88% (TANDEM, 0-3% index), 88% (Isomune, 0-14 U/L), and 83% (Isomune, 0-4%). All three methods can detect CK-MB in serum, but its presence is not necessarily diagnostic of acute infarct. We recommend using the actual concentration of CK-MB to evaluate patients with suspected acute myocardial infarct, and the percentage of CK-MB when total CK is very high.
Modulation of synaptic plasticity by stress and antidepressants (2002)

Recent preclinical and clinical studies have shown that mechanisms underlying neuronal plasticity and survival are involved in both the outcome of stressful experiences and the action of antidepressants. Whereas most antidepressants predominantly affect the brain levels of monoamine neurotransmitters, it is increasingly appreciated that they also modulate neurotransmission at synapses using the neurotransmitter glutamate (the most abundant in the brain). In the hippocampus, a main area of the limbic system involved in cognitive functions as well as attention and affect, specific molecules enriched at glutamatergic synapses mediate major changes in synaptic plasticity induced by stress paradigms or antidepressant treatments. We analyze here the modifications induced by stress or antidepressants in the strength of synaptic transmission in hippocampus, and the molecular modifications induced by antidepressants in two main mediators of synaptic plasticity: the N-methyl-D-aspartate (NMDA) receptor complex for glutamate and the Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). Both stress and antidepressants induce alterations in long-term potentiation of hippocampal glutamatergic synapses, which may be partly accounted for by the influence of environmental or drug-induced stimulation of monoaminergic pathways projecting to the hippocampus. In the course of antidepressant treatments significant changes have been described in both the NMDA receptor and CaM kinase II, which may account for the physiological changes observed. A central role in these synaptic changes is exerted by brain-derived neurotrophic factor (BDNF), which modulates both synaptic plasticity and its molecular mediators, as well as inducing morphological synaptic changes. The role of these molecular effectors in synaptic plasticity is discussed in relation to the action of antidepressants and the search for new molecular targets of drug action in the therapy of mood disorders.
Single sign-on with one time password (2009)

The organizations are shifting from the desktop based solution to Web based platform to solve their business needs. The amass of these different systems poses problems for end-users, who must frequently provide their username/password across different systems, as well as for system administrators, who must manage security and access for those systems. Single sign-on mechanisms have become increasingly important in solving these problems. Although there are several ways to implement single sign-on feature (e.g. Kerberos and X.509), it may be difficult to modify a particular existing application to comply with the different protocols imposed by the new authentication mechanism. Moreover, these methods of implementing single sign-on require the new infrastructure which will cost both time and money. This might creates hindrance to the small organization for the implementation of single sign-on feature. Present study proposes a method of implementing single sign-on using the one time password. In this approach, when user manually authenticates in the portal site and tries to login into the subsequent applications then one time password is generated for that session and this password is used to authenticate the user into the applications. This method eliminates the necessity of setting up the new infrastructure and also the existing system requires minimal changes to incorporate the single sign-on feature in it. Hence, the organization can implement the solution in a cost effective manner.
Sexual side effects of SSRI medications: potential treatment strategies for SSRI-induced female sexual dysfunction. (2002)

Depression often coexists with sexual dysfunction, and the medical treatment of depression can further worsen sexual symptoms or cause de novo sexual dysfunction in a person who did not experience it prior to treatment. There are many drugs that can adversely affect sexual response. Among antidepressants, this effect is commonly observed with selective serotonin-reuptake inhibitors (SSRI). Various strategies for the treatment of SSRI-related sexual dysfunction have been studied, including: awaiting spontaneous remission of sexual dysfunction; reducing the dose of medication; taking a "drug holiday"; adding another drug to help reverse sexual symptoms; changing antidepressants; or initially starting with a different antidepressant that is known to have fewer or no sexual side effects. Overall, it is important to address sexual health when caring for a patient--to improve drug compliance and the patient's well being.
A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery (2015)

The discovery of new antimalarials with transmission blocking activity remains a key issue in efforts to control malaria and eventually eradicate the disease. Recently, high-throughput screening (HTS) assays have been successfully applied to Plasmodium falciparum asexual stages to screen millions of compounds, with the identification of thousands of new active molecules, some of which are already in clinical phases. The same approach has now been applied to identify compounds that are active against P. falciparum gametocytes, the parasite stage responsible for transmission. This study reports screening results for the Tres Cantos Antimalarial Set (TCAMS), of approximately 13,533 molecules, against P. falciparum stage V gametocytes. Secondary confirmation and cytotoxicity assays led to the identification of 98 selective molecules with dual activity against gametocytes and asexual stages. Hit compounds were chemically clustered and analyzed for appropriate physicochemical properties. The TCAMS chemical space around the prioritized hits was also studied. A selection of hit compounds was assessed ex vivo in the standard membrane feeding assay and demonstrated complete block in transmission. As a result of this effort, new chemical structures not connected to previously described antimalarials have been identified. This new set of compounds may serve as starting points for future drug discovery programs as well as tool compounds for identifying new modes of action involved in malaria transmission.
Diagnosis of Hypolactasia and Lactose Malabsorption (1994)

The article briefly describes the various methods that are available for diagnosing hypolactasia. Special attention is drawn to the fact that different methods are useful at different levels of the health care organization. When the test result indicates lactose malabsorption, general malabsorption should be excluded by a glucose-galactose tolerance test, for example. If the glucose-galactose tolerance test produces a normal result, it can be assumed that the patient has primary adult-type selective lactose malabsorption. The possibility of secondary lactose malabsorption must be excluded according to the principles described by Villako & Maaroos (104).
CHAPTER 4: INORGANIC PHOSPHORUS POLYMERS (1968)

Abstract The term inorganic polymers comprises polymers whose main chains (linear, branched, or cross-linked) have no carbon atoms. The side groups may contain carbon. Obviously, inorganic polymers with organic side groups are particularly interesting because the physicomechanical properties required of plastics, such as plasticity, elasticity, solubility. fusibility, etc., are primarily obtained by introducing organic groups into inorganic polymer chains. In this text, reference is made to the commonly known differences between polysilicates and polysiloxanes (silicones). The great interest attached to inorganic polymers is due mainly to the search for plastics of high thermal stability. Various recent reviews summarizing the theoretical and experimental findings [G8,H6,Ll,Sl5,Y3] are available on inorganic polymers. Phosphorus-containing inorganic polymers have been included in all these monographs.
Antibody Binding to Antigen-Coated Substrates Studied with Surface Plasmon Oscillations (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntibody Binding to Antigen-Coated Substrates Studied with Surface Plasmon OscillationsJ. R. Rahn and R. B. HallockCite this: Langmuir 1995, 11, 2, 650–654Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/la00002a049https://doi.org/10.1021/la00002a049research-articleACS PublicationsRequest reuse permissionsArticle Views362Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermoelectric properties of superlattice nanowires (2003)

We report here on a theoretical model for the electronic structure and transport properties of superlattice nanowires, considering their cylindrical wire boundary and multiple anisotropic carrier pockets. The thermoelectric properties of superlattice nanowires made of various lead salts (PbS, PbSe, and PbTe) are investigated as a function of the segment length, wire diameter, crystal orientation along the wire axis, and the length ratio of the constituent nanodots of the superlattice, based on the Kronig-Penney potential for each one-dimensional (1D) subband and on the 1D Boltzmann transport equations. A potential barrier--well inversion induced by quantum confinement, which is a unique phenomenon in superlattice nanowires, is predicted as the wire diameter decreases. $\mathrm{ZT}$ values higher than 4 and 6 are predicted for 5-nm-diameter PbSe/PbS and PbTe/PbSe superlattice nanowires at 77 K, respectively. These ZT values are significantly larger than those of their corresponding alloy nanowires, indicating that superlattice nanowires are promising systems for thermoelectric applications.
Ontario, Department of Planning and Development. <i>Conservation in Eastern Ontario</i> (1946)

"Ontario, Department of Planning and Development. Conservation in Eastern Ontario." Canadian Historical Review, 27(4), pp. 444–445
An interaction network of proteins involved in spinocerebellar ataxias (2011)

<b>Copyright information:</b>Taken from "Protein-protein interaction networks in the spinocerebellar ataxias"Genome Biology 2006;7(8):229-229.Published online 10 Aug 2006PMCID:PMC1779585. The yeast two-hybrid interaction data of Lim . [1] reveal one large interconnected network consisting of 752 protein-protein interactions between 36 ataxia-associated proteins and 541 prey proteins. Circles (nodes) represent proteins, and any two proteins connected by a line have been shown to interact in the yeast two-hybrid (Y2H) screen. Blue circles depict protein baits corresponding to the proteins known to be mutated in ataxias; red circles depict protein baits that are paralogs of ataxia-causing proteins or known interactors with them. The yellow circles depict prey proteins tested in the yeast two-hybrid screen and come from two sources. Those connected by a purple line to a node come from the human open reading frame library (the hORFeome), while those connected by a green line come from a human brain cDNA library. All lines represent either first- or second-order interactions to ataxia-causing proteins. First-order interactions are direct interactions, while second-order interactions occur via an intermediary protein. Reproduced with permission from Elsevier [1].
A two-component phosphotransfer network involving ArcB, ArcA, and RssB coordinates synthesis and proteolysis of σ<sup>S</sup> (RpoS) in <i>E. coli</i> (2005)

The general stress sigma factor sigma(S) (RpoS) in Escherichia coli is controlled at the levels of transcription, translation, and proteolysis. Here we demonstrate that the phosphorylated response regulator ArcA is a direct repressor of rpoS transcription that binds to two sites flanking the major rpoS promoter, with the upstream site overlapping an activating cAMP-CRP-binding site. The histidine sensor kinase ArcB not only phosphorylates ArcA, but also the sigma(S) proteolytic targeting factor RssB, and thereby stimulates sigma(S) proteolysis. Thus, ArcB/ArcA/RssB constitute a branched "three-component system", which coordinates rpoS transcription and sigma(S) proteolysis and thereby maintains low sigma(S) levels in rapidly growing cells. We suggest that the redox state of the quinones, which controls autophosphorylation of ArcB, not only monitors oxygen but also energy supply, and we show that the ArcB/ArcA/RssB system is involved in sigma(S) induction during entry into starvation conditions. Moreover, this induction is enhanced by a positive feedback that involves sigma(S)-dependent induction of ArcA, which further reduces sigma(S) proteolysis, probably by competing with RssB for residual phosphorylation by ArcB.
Transfer-function synthesis using a single operational amplifier (1967)

A simple method of active RC realisation of a voltage-transfer ratio is proposed. The final structure employs a single operational amplifier.
An emerging marketplace for digital advertising based on amalgamated digital signage networks (2003)

Digital signage networks are a newly emerging form of electronic advertising technology that is rapidly growing in popularity but has received little attention in e-commerce (electronic commerce) literature. We motivate the cost reduction and increased effectiveness of advertising that is displayed and managed using digital signage networks as opposed to traditional signage. We introduce a partially automated intermediary, namely the digital signage exchange that forms a virtual marketplace for the purchase and sale of display time on the digital signage network. We present a concise representation for a customer's order for display time on the digital signage network and an informal business transaction management model for the exchange. This model includes support for advance bulk purchase of blocks of display time. It can also make a counter-offer to the customer when an order cannot be completely fulfilled as requested.
Naturally occurring, optically driven, cellular rotor (2004)

We report the conversion of optical energy into mechanical energy by naturally occurring red blood cells (RBCs) placed in an optical trap. A trapped RBC undergoes folding due to the elastic nature of its cell membrane. On use of circularly polarized light in the trap, the folded RBCs rotate, indicating their birefringence. The cellular rotation speed depends on the size of the blood cells and on laser power. Rotating RBCs have implications for naturally occurring, optically driven, rotary micromachines.
Comparing representations with relational and EER models (1990)

The diffusion of technology to end users who can now develop their own information systems raises issues concerning the cost, quality, efficiency, and accuracy of such systems.
Guidelines for the provision of video viewing facilities in libraries (1984)

Elements d'information pour l'equipement des bibliotheques d'universitaires, des bibliotheques publiques et elements de reflexion sur l'introduction du disque optique
Rod and cone contrast gains derived from reaction time distribution modeling (2010)

Contrast gain reflects the rapidity of response amplitude increase with increase in stimulus contrast. In physiology, contrast gain can be measured directly as the initial slope of cell contrast response function. In psychophysics, contrast gain estimation is not straightforward. Further, rod and cone contrast gains have not been measured psychophysically at mesopic light levels where both rods and cones are active, due to the difficulty in producing stimuli that excite rods and cones separately at the same adaptation level. Here, we estimated rod and contrast gains by fitting reaction time distributions measured at a light level in which rods alone (scotopic), rods and cones (mesopic), or cones alone (photopic) mediate vision. The reaction time distributions were modeled by two different strategies, a simplified diffusion model that assumes a stochastic accumulation process and a model we developed that begins with sensory input based on early visual processing impulse response functions and assumes the reaction time variability originates in the response criterion. Estimates of contrast gain from both models were comparable and consistent with primate physiology measurements.