gebhart/patrepeval huggingface dataset:
Usage of OLAP-means of the system "analytics" for the problem of health protection (2005)

The health care sector has been experiencing some difficulty as a result of the implementation of some new principles in planning and management and the continuous accumulation of electronic information. To help ease the situation, the use of an analytical modeling software, called OLAP (online analytical processing), is suggested. With the aid of OLAP, the capability of business analysis is significantly improved in terms of increased operation speed, presentation of the results and operative design of analytical reports.
Evaluation of Predictors of the Development of Azotemia in Cats (2009)

Abstract Background Chronic kidney disease (CKD) is a common condition in geriatric cats. Diagnosis is based on the development of persistent azotemia with inadequate urine concentrating ability. Biomarkers are sought for early identification. Hypothesis Clinical variables, urine concentrating ability, proteinuria, and N-acetyl-β-d-glucosaminidase (NAG) index will be predictive of cats at risk of developing azotemia within 12 months. Animals Client-owned nonazotemic geriatric (≥9 years) cats. Methods Prospective longitudinal cohort study monitoring a population of healthy nonazotemic geriatric cats every 6 months until development of azotemia, death, or the study end point (September 30, 2007). Multivariable logistic regression analysis was used to assess baseline clinical, biochemical, and urinalysis variables, urine protein to creatinine ratio (UP/C), urine albumin to creatinine (UA/C) ratio, and urinary NAG index as predictors of development of azotemia. Results One hundred and eighteen cats were recruited with a median age of 13 years. Ninety-five cats (80.5%) had been followed or reached the study end point by 12 months of which 30.5% (29/95) developed azotemia. Age, systolic blood pressure, plasma creatinine concentration, urine specific gravity, UP/C, UA/C, and NAG index were significantly associated with development of azotemia in the univariable analysis (P≤ .05). However, in the multivariable analysis, only plasma creatinine concentration with either UP/C (Model 1) or UA/C (Model 2) remained significant. Conclusions and Clinical Importance This study demonstrates a high incidence of azotemia in a population of previously healthy geriatric cats. Proteinuria at presentation was significantly associated with development of azotemia although causal association cannot be inferred. Evaluation of NAG index offered no additional benefit.
Handbook of Citrus By-Products and Processing Technology (1999)

The Citrus Industry. Fruit Growing, Harvesting, Handling, and Grading for Processing. Composition, Properties, and Evaluation of Fruit Components. Juice Processing Operations. Single-Strength Juices and Concentrate. Juice Chemical Reactions, Product Stability, and Packaging. Pulp Washing, Juice Pulp Recovery, and Utilization. Whole Juice Cells, Drum-Dried Juice Sacs, and Sections. Peel Fiber, Cloud, and Products. Dried Pulp, Pellets, and Molasses. Essential Oils and Essences. d-Limonene. Pectin. Bioconversion Products. Flavonoids and Limonoids. Seed Products. Nutraceuticals, Mystical Substances, and By-Products.
Automated Nematode Tracking System (2016)

Many diseases, such as Parkinson's disease and heavy metal poisoning, are associated with impaired or aberrant locomotion. Because the underlying mechanisms are difficult to study in humans, simpler metazoans like Caenorhabditis elegans are commonly employed to model these diseases. C. elegans is especially useful in this respect because its innate electrotactic behaviour allows instantaneous manipulation of its locomotion using mild electric fields in a microfluidic environment, the results of which can be captured on video. However, extraction of locomotory data from these videos is a major bottleneck to the throughput of the microfluidic electrotaxis platform. In the present study, we describe the development of novel software to analyze electrotaxis videos in an automated fashion. The software, dubbed the Automated Nematode Tracking System (ANTS), uses efficient, parameterless computer vision techniques to simultaneously track and assess movement characteristics of ambulating animals. In combination with the previously described microfluidic electrotaxis platform, ANTS promises to accelerate research with C. elegans models of locomotory dysfunction.
Development of a monolithic FET Ka-band single side band upconverter and image reject downconverter (2003)

A GaAs monolithic, single-sideband (SSB), Ka-band FET upconverter is being developed for use in a miniature coherent radar transceiver module, along with a monolithic image reject downconverter. The SSB upconverter IC comprises balanced FET converters, Lange couplers, and an IF quadrature splitter. The balanced FET converters provide 7 dB of conversion loss and 28 dB of LO rejection. The SSB IC, currently in fabrication, is expected to provide 8 dB of conversion loss, 5 dBm of output power, and 28 dB of LO and 20 dB of lower sideband rejection. The image reject downconverter IC comprises a balanced pair of FET converters. Lange couplers, a Wilkinson divider, and a lumped element branchline coupler. The single FET converters produced 1 dB of conversion gain with a 5.5-dB noise figure, DSB. The image reject downconverter, currently in fabrication, is expected to provide 0 dB of conversion gain and 20 dB of image rejection with a noise figure of 9 dB, SSB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Coupling Ribose Selection to Fidelity of DNA Synthesis (2000)

The catalytic efficiency of incorporation of deoxyribonucleotides by wild-type human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) was around 100-fold higher than for dideoxyribonucleotides, in Mg(2+)-catalyzed reactions, and more than 10,000-fold higher than for nucleotides having a 2'-hydroxyl group in Mg(2+)- and Mn(2+)-catalyzed reactions. Mutant RTs with nonconservative substitutions affecting Tyr-115 (Y115V, Y115A, and Y115G) showed a dramatic reduction in their ability to discriminate against ribonucleotides in the presence of both cations. However, selectivity of deoxyribonucleotides versus ribonucleotides was not affected in mutants Y115W and F160W. The substitution of Tyr-115 with Val or Gly had no effect on discrimination against dideoxyribonucleotides, but these mutants were less efficient than the wild-type RT in discriminating against cordycepin 5'-triphosphate. We also show that Tyr-115 is involved in fidelity of DNA synthesis, but substitutions at this position have different effects depending on the metal cofactor used in the assays. In Mg(2+)-catalyzed reactions, removal of the side chain of Tyr-115 reduced misinsertion and mispair extension fidelity, while opposite effects were observed in Mn(2+)-catalyzed reactions. Our results indicate that the aromatic side chain of Tyr-115 plays a role as a "steric gate" preventing the incorporation of nucleotides with a 2'-hydroxyl group in a cation-independent manner, while its influence on fidelity could be modulated by Mg(2+) or Mn(2+).
Human growth hormone site 2 lactogenic activity requires a distant tyrosine164 (1999)

Comparison of crystallographic structures of human growth hormone, either bound to the prolactin receptor or free of receptors, reveals that human growth hormone binding to the prolactin receptor at site 1 is associated with a structural change in human growth hormone that influences the organization of residues which constitute site 2. We have identified Tyr164 as a residue that is critical for the propagation of this structural rearrangement. Tyr164 is a structural epitope for site 1 and is distal to site 2. Mutation of Tyr164 to glutamic acid (Y164E) does not affect the somatotrophic activity, absorption or fluorescence spectra or binding to the human prolactin receptor when compared to wild-type human growth hormone, indicating the subtle effects of the mutation. Lactogenic assays using extended concentrations of Y164E human growth hormone produce dose-response curves that are characterized by a right-shifted agonist phase and an unchanged antagonist phase when compared to wild-type human growth hormone. These results indicate that Tyr164 is required for the lactogenic activity of human growth hormone and that mutation to glutamic acid disrupts the lactogenic function of site 2.
Cell-mediated immune responses of guinea pigs to an inactivated phase I Coxiella burnetii vaccine (1978)

The ability of a killed phase I Coxiella burnetii vaccine to induce cell-mediated immune responses in guinea pigs was studied. Cell-mediated immune responses were assessed by the inhibition of macrophage migration and lymphocyte transformation assays. The macrophage migration response occurred rapidly and was detected at high levels, but was relatively short-lived. In contrast, the lymphocyte transformation response developed more slowly, and persisted for a longer period. The vaccine, given in a single dose or in two doses 1 week apart, protected guinea pigs from a subsequent virulent challenge.
Impact of Serotherapy on Immune Reconstitution and Survival Outcomes After Stem Cell Transplantations in Children: Thymoglobulin Versus Alemtuzumab (2014)

The outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is strongly affected by the kinetics of reconstitution of the immune system. This study compared the effects of antithymocyte globulin (ATG) and alemtuzumab on various outcome parameters after HSCT. The study cohort consisted of 148 children, with a median age of 9.6 years (range, .4 to 19.0), who underwent HSCT for malignant and benign hematological disorders in a single HSCT unit. Conditioning included ATG (n 110) or alemtuzumab (n 38). Cox proportional hazard regression analysis showed that alemtuzumab significantly delayed the recovery of CD3 T cells and CD4 as well as CD8 T cell subsets (P .001) and natural killer (NK) cells (P .008) compared with ATG. In both ATG-and alemtuzumab-treated patients, shorter drug exposure lead to significantly faster recovery of T cells. Alemtuzumab was associated with lower donor chimerism 3 and 6 months after transplantation and a higher risk of disease relapse (P .001). The overall survival and event-free survival risks were significantly lower for alemtuzumab-treated patients (P .020 and P < .001, respectively). Patients who received alemtuzumab showed a trend to lower risk of acute graft-versus-host disease, more human adenovirus, and less Epstein-Barr virus reactivations compared with patients who received ATG. These data indicate that children treated with alemtuzumab as part of the conditioning regimen have a slower T cell and NK cell reconstitution compared with those treated with ATG, which compromises the overall and event-free survival. Prolonged length of lympholytic drug exposure delayed the T cell recovery in both ATGand alemtuzumab-treated patients. Therefore, we recommend detailed pharmacokinetic/pharmacodynamic (PK/PD) analyses in a larger cohort of patients to develop an algorithm aiming at optimization of the serotherapy containing conditioning regimen.
Treating Influenza Infection, From Now and Into the Future (2018)

Influenza viruses (IVs) are a continual threat to global health. The high mutation rate of the IV genome makes this virus incredibly successful, genetic drift allows for annual epidemics which result in thousands of deaths and millions of hospitalizations. Moreover, the emergence of new strains through genetic shift (e.g., swine-origin influenza A) can cause devastating global outbreaks of infection. Neuraminidase inhibitors (NAIs) are currently used to treat IV infection and act directly on viral proteins to halt IV spread. However, effectivity is limited late in infection and drug resistance can develop. New therapies which target highly conserved features of IV such as antibodies to the stem region of hemagglutinin or the IV RNA polymerase inhibitor: Favipiravir are currently in clinical trials. Compared to NAIs, these treatments have a higher tolerance for resistance and a longer therapeutic window and therefore, may prove more effective. However, clinical and experimental evidence has demonstrated that it is not just viral spread, but also the host inflammatory response and damage to the lung epithelium which dictate the outcome of IV infection. Therapeutic regimens for IV infection should therefore also regulate the host inflammatory response and protect epithelial cells from unnecessary cell death. Anti-inflammatory drugs such as etanercept, statins or cyclooxygenase enzyme 2 inhibitors may temper IV induced inflammation, demonstrating the possibility of repurposing these drugs as single or adjunct therapies for IV infection. IV binds to sialic acid receptors on the host cell surface to initiate infection and productive IV replication is primarily restricted to airway epithelial cells. Accordingly, targeting therapies to the epithelium will directly inhibit IV spread while minimizing off target consequences, such as over activation of immune cells. The neuraminidase mimic Fludase cleaves sialic acid receptors from the epithelium to inhibit IV entry to cells. While type III interferons activate an antiviral gene program in epithelial cells with minimal perturbation to the IV specific immune response. This review discusses the above-mentioned candidate anti-IV therapeutics and others at the preclinical and clinical trial stage.
SQL Server 2008 Administration in Action (2009)

Server 2008 Administration isn't a standard Server tutorial-there are dozens of those to choose from. Instead, this book breaks down the role of SQL Server Administrator into its key focus areas and tasks and details the techniques and best practices that make an administrator effective. In this book, a reader can quickly identify a task and find the best practice associated with it. For example, a reader looking for information about indexing would find step-by-step procedures for identifying and dropping unused indexes, creating missing indexes, selecting the appropriate clustered index, and so forth. Each technique is presented in a clear, straightforward style and in the order of the typical lifecycle of a Server system. This allows a reader to easily open the book at the appropriate page and focus on what you need to know for each specific situation. While most techniques will work for all versions of Server, this book is current for the recent final release of Server 2008.
Optimal Routing in Binomial Graph Networks (2007)

A circulant graph with n nodes and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">jumps</i> j <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> , j <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ,..., j <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> is a graph in which each node i, 0 les i les n-1, is adjacent to all the vertices i plusmn j <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sub> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">mod</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</i> , where 1 les k les m. A binomial graph network (BMG) is a circulant graph where jk is the power of 2 that is less than or equal to n. This paper presents an optimal (shortest path) two-terminal routing algorithm for BMG networks. This algorithm uses only the destination address to determine the next hop in order to stay on the shortest path. Unlike the original algorithms, it does not require extra space for routing tables or additional information in the packet. The experimental results show that the new optimal algorithm is significantly faster than the original optimal algorithm.
Heteroepitaxial growth of Ge films on the Si(100)-2×1 surface (1985)

The initial stage of Ge heteroepitaxy on a Si(100)-2×1 surface has been investigated by low-energy electron diffraction (LEED) and Auger-electron spectroscopy (AES). The growth mode of the Ge films was studied by measuring the decrease in the Si(LVV) AES line at 92 eV with an increase in the Ge overlayer thickness. The Ge films deposited at room temperature exhibit layer-by-layer growth up to at least six monolayers. When the substrate is heated up to 350 °C, the growth mode is characterized by the Stranski–Krastanov type; i.e., the first three monolayers of growth is followed by island formation. Although these characteristics of the growth mechanism are similar to the case of Ge on Si(111)-7×7 surfaces, annealing behavior of the Ge films suggests that the bond strength between Ge and Si is stronger on Si(100) than on Si(111) surfaces. In contrast to the case of Ge on Si(111) surfaces, where the original 7×7 superstructure of the Si surface is replaced by a new 5×5 pattern at about two-monolayer coverage of Ge, the original 2×1 LEED pattern is not strongly disturbed up to about 1–2 monolayers of Ge. In addition to the detailed study on the initial stage of heteroepitaxial growth, we observed that thick Ge films deposited onto Si(100) surfaces held at 350 and 470 °C display a sharp 2×1 LEED pattern and demonstrate a single-crystal growth of a Ge(100) face on the Si(100) surface. This is further supported by a measurement of the x-ray diffraction pattern of the Ge films.
Coronavirus (Covid-19) (2020)

Help and support from Harthill with Woodall / Thorpe Salvin Covid-19 Community Support during the coronavirus pandemic.
Quantitative Clinical Pathology (1995)

Part 1: Measurement in Microscopic Pathology: Stereology Interactive Computer-aided Morphometry Mitotic Counts General Applications of Morphometry Nucleolar Organizer Regions DNA Densitometry Automated Image Cytometry Part 2: Flow Cytometry: The Flow Cytometer Disaggregation of Solid Tumours DNA Ploidy Analysis by Flow Cytometry Cell Kinetic Studies Using Flow Cytometry Immunological Applications of Flow Cytometry Part 3: Current Developments: Expert Systems for Histopathology Three-dimensional Reconstruction Fractal Geometric Analysis in Pathology Part 4: Study Design and Statistical Considerations: Designing a Morphometric Study Statistical Analysis of Morphometric and Clinical Data Index
Wireless Channel Equalization in Digital Communication Systems (2012)

Our modern society has transformed to an information-demanding system, seeking voice, video, and data in quantities that could not be imagined even a decade ago. The mobility of communicators has added more challenges. One of the new challenges is to conceive highly reliable and fast communication system unaffected by the problems caused in the multipath fading wireless channels. Our quest is to remove one of the obstacles in the way of achieving ultimately fast and reliable wireless digital communication, namely Inter-Symbol Interference (ISI), the intensity of which makes the channel noise inconsequential. The theoretical background for wireless channels modeling and adaptive signal processing are covered in first two chapters of dissertation. The approach of this thesis is not based on one methodology but several algorithms and configurations that are proposed and examined to fight the ISI problem. There are two main categories of channel equalization techniques, supervised (training) and blind unsupervised (blind) modes. We have studied the application of a new and specially modified neural network requiring very short training period for the proper channel equalization in supervised mode. The promising performance in the graphs for this network is presented in chapter 4. For blind modes two distinctive methodologies are presented and studied. Chapter 3 covers the concept of multiple "cooperative" algorithms for the cases of two and three cooperative algorithms. The "select absolutely larger equalized signal" and "majority vote" methods have been used in 2-and 3-algoirithm systems respectively. Many of the demonstrated results are encouraging for further research. Chapter 5 involves the application of general concept of simulated annealing in blind mode equalization. A limited strategy of constant annealing noise is experimented for testing the simple algorithms used in multiple systems. Convergence to local stationary points of the cost function in parameter space is clearly demonstrated and that justifies the use of additional noise. The capability of the adding the random noise to release the algorithm from the local traps is established in several cases.
Practical Detection of Spammers and Content Promoters in Online Video Sharing Systems (2011)

A number of online video sharing systems, out of which YouTube is the most popular, provide features that allow users to post a video as a response to a discussion topic. These features open opportunities for users to introduce polluted content, or simply pollution, into the system. For instance, spammers may post an unrelated video as response to a popular one, aiming at increasing the likelihood of the response being viewed by a larger number of users. Moreover, content promoters may try to gain visibility to a specific video by posting a large number of (potentially unrelated) responses to boost the rank of the responded video, making it appear in the top lists maintained by the system. Content pollution may jeopardize the trust of users on the system, thus compromising its success in promoting social interactions. In spite of that, the available literature is very limited in providing a deep understanding of this problem. In this paper, we address the issue of detecting video spammers and promoters. Towards that end, we first manually build a test collection of real YouTube users, classifying them as spammers, promoters, and legitimate users. Using our test collection, we provide a characterization of content, individual, and social attributes that help distinguish each user class. We then investigate the feasibility of using supervised classification algorithms to automatically detect spammers and promoters, and assess their effectiveness in our test collection. While our classification approach succeeds at separating spammers and promoters from legitimate users, the high cost of manually labeling vast amounts of examples compromises its full potential in realistic scenarios. For this reason, we further propose an active learning approach that automatically chooses a set of examples to label, which is likely to provide the highest amount of information, drastically reducing the amount of required training data while maintaining comparable classification effectiveness.
<i>Thaleropia</i> , a New Genus for <i>Metrosideros queenslandica</i> (Myrtaceae) and its Allies (1993)

The taxonomic status of Metrosideros queenslandica, and related species from New Guinea, is reassessed on the basis of fundamental morphological and anatomical characters and these species are found to be more closely allied to Tristanin sens. str. than to Metrosideros sens. lat. The current classification of this group of species as Metrosideros subg. Mearnsia sect. Adnatae J. W. Dawson is rejected and a new genus, Thaleropia, is described and the new combinations T. queeirslandica, T. iteophylla and T. hypargyrea made.