gebhart/patrepeval huggingface dataset:
Evaluation of Antibodies and Microarray Coatings As a Prerequisite for the Generation of Optimized Antibody Microarrays (2004)

Antibody microarrays are becoming a major tool for the parallel analysis of complex samples. So far, many efforts have been made to increase the complexity and sensitivity of antibody microarrays. In contrast to enzyme-linked immunosorbent assay (ELISA) experiments, not all antibodies remain functional in the microarray format. Sensitivity is very much dependent on the type of coating and its application. The method described in this chapter is a quick and reliable method that has been very useful in determining the functionality of antibodies and the suitability of coatings for antibody microarrays. At the same time, a detailed description of how to prepare an inexpensive and highly efficient antibody microarray surface is given.
Consumer Participation in Identifying Research and Development Priorities for Power Wheelchair Input Devices and Controllers (1995)

A focus group comprised of persons who use power wheelchairs and professionals working in the field were asked to participate in a brainstorming session to determine priorities for the development and application of power mobility input devices and control concepts. The group consensus was that durability and reliability are the most important criteria. Essentially, the expectation is that a power wheelchair must work everyday in the way a person needs it and wants it. At the same time, there is a desire to enhance and advance the features of input devices and control systems. Many would say these changes constitute designing "smarter" power wheelchairs, such as systems that can independently detect obstacles and can provide users with more feedback. This paper presents the rationale behind forming this focus group and details of the results of a brainstorming session where ideas were generated and prioritized. The five most important issues as determined by the group are discussed in depth.
Templat‐Synthese makrobicyclischer Großhohlräume vom Tris(bipyridin)‐Typ (1989)

Abstract Die Liganden 2 und 3 wurden in einer Eintopf‐Synthese ausgehend von den Triaminen 11 und 12 sowie 5,5′‐Bis(brommethyl‐2,2′‐bipyridin ( 6 ) erhalten und als Natrium‐Komplexe isoliert und charakterisiert. Die dynamische 1 H‐NMR‐Spektroskopie des Komplexes 2 · Na ⊕ belegt seine konformative Beweglichkeit.
Finite sample properties of system identification methods (2002)

In this paper we study the quality of system identification models obtained using the standard quadratic prediction error criterion for a general linear model class. The main feature of our results is that they hold true for a finite data sample and they are not asymptotic. The main theorems bound the difference between the expected value of the identification criterion evaluated at the estimated parameters and at the optimal parameters. The bound depends naturally on the model and system order, the pole locations, and the noise variance, and it shows that although these variables often do not enter in asymptotic convergence results, they do play an important role when the data sample is finite.
MEASUREMENT OF THE ELECTRON-ASYMMETRY PARAMETER OF ^~^n + e"" +V (1967)

Author(s): Gershwin, Lawrence K.; Alston-Garnjost, Margaret; Bangerter, Roger O.; Barbaro-Galtieri, Angela; Mast, Terry S.; Murray, Joseph J.; Solmitz, Frank T.; Stevenson, M. Liynn; Tripp, Robert D.; Verglas, Alain J.; Webber, Bryan R.
Zn/sub 3/P/sub 2/ as an improved semiconductor for photovoltaic solar cells. Thirteenth quarterly report, September 1, 1981-November 30, 1981 (1982)

Efforts to produce bulk n-type Zn/sub 3/P/sub 2/ by incorporating Mg as an impurity have so far resulted in high resistivity p-type material. On the basis of the capacitance voltage characteristics of Mg diffused Zn/sub 3/P/sub 2/ devices, a model in which Mg compensates the acceptor levels, creating a thin insulating region near the surface, was developed. In order to test the validity of this model, the thickness of the Mg diffused layer was measured by first heating a Mg/Zn/sub 3/P/sub 2/ device to produce approx. 50 ..mu..m thick Mg diffused layer and then measuring the device characteristics after successively removing a few ..mu..m of the surface at a time. This experiment confirmed the results reported earlier on the basis on n/p junction formation. A study of the native oxide of Zn/sub 3/P/sub 2/ produced by thermal oxidation was conducted for the development of MIS solar cells. The oxidized surface was composed of ZnO and P/sub 2/O/sub 5/ and was found to contain excess zinc. The as-grown oxide layer in Zn/sub 3/P/sub 2/ was electrically conducting and, therefore, not suitable for MIS cells. MIS cells produced by plasma oxidation of Zn/sub 3/P/sub 2/ had V/sub oc/ approx. 0.5 Volts andmore » J/sub 0/ approx. 10/sup -9/ Amp/cm/sup 2/. A software package to store, sort and retrieve the data generated by the production and testing of Zn/sub 3/P/sub 2/ thin-film cells was developed. ZnSe/Zn/sub 3/P/sub 2/ heterojunction devices prepared by vacuum evaporation of ZnSe had a maximum V/sub oc/ of 0.36 Volts and J/sub sc/ in the range of 0.1 and 0.7 mA/cm/sup 2/. The resistivity of ZnSe films was lowered by annealing in the presence of zinc vapor at 400/sup 0/C. Al doping in ZnSe gave very leaky diodes and a lower V/sub oc/. Optical absorption measurements were made on thin ZnSe films deposited on glass by vacuum evaporation and close-spaced vapor transport.« less
Corrosion Performance of Modified 13CR OCTG (1996)

Abstract Sour resistant 13% Cr martensitic stainless steel OCTG (Oil Country Tubular Goods) with high CO2-corrosion resistance was developed. Additions of Cu and Ni in combination with an addition of Mo resulted in improved corrosion performance. CO2-corrosion rates were studied at various chloride ion concentration levels and at various temperatures. Microstructural observation revealed that the corrosion film of the 13%Cr with combined additions of Cu and Ni is amorphous, which is supposed to be the mechanism for the high corrosion resistance. Sulfide stress cracking (SSC) resistance was also studied as functions of pH and H2S partial pressure. It was found that SSC occurrence can be predicted by comparing the pitting potential with sulfur reduction potential. Finally the advantages of the newly developed 13%Cr OCTG are presented from the view points of high strength, high temperature and sour applications.
<b>Hydroboration. XIII. The Hydroboration of Dienes with Disiamylborane. A Convenient Procedure for the Conversion of Selected Dienes into Unsaturated Alcohols</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroboration. XIII. The Hydroboration of Dienes with Disiamylborane. A Convenient Procedure for the Conversion of Selected Dienes into Unsaturated AlcoholsGeorge. Zweifel, Kunihko. Nagase, and Herbert C. BrownCite this: J. Am. Chem. Soc. 1962, 84, 2, 190–195Publication Date (Print):January 1, 1962Publication History Published online1 May 2002Published inissue 1 January 1962https://pubs.acs.org/doi/10.1021/ja00861a013https://doi.org/10.1021/ja00861a013research-articleACS PublicationsRequest reuse permissionsArticle Views857Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fundamental Analysis of a Precession Motion Ball Reducer (2nd Report)-Motion Principle of an Orthogonal Axis Output Type- (2003)

The orthogonal axis output type precession motion ball reducer has been newly developed The element of the reducer consists of five components; an inclined input shaft a fixed ring, a precession motion rotor with freely rotating balls, a spherical converting rotor of the precession motion and an output ring. Especially, this converting rotor makes a precession motion around the different rotating axis, which axis is orthogonal to an input shaft Also, the freely rotating balls are arranged on the precession motion rotor, which positions are different from the co-axial output type. This is the only method of the solution, which can eliminate the backlash for the orthogonal axis output type reducer. In this report, the motion principle is analyzed using the polar complex vectors analysis which is similar to the co-axial output type. It is proved that the position of each ball attached on the precession motion rotor is the important parameter as like the co-axial output type. Also the offset angle of that converting rotor is important, too.
Prostaglandins: Their role in egg-laying of the cricket <i>Teleogryllus commodus</i> (1981)

Mating of the Teleogryllus commodus female causes increased oviposition mediated by PGE(2), which is synthesized in the female's spermatheca from the precursor, arachidonic acid, in the presence of a PG-synthesizing complex. The latter, together with sperm, is transferred from the male to the female via a spermatophore. Only nanogram quantities of PGE(2) injected into oviduct are necessary to simulate mating-induced egg release.
The AWARE Study: Methodology and Baseline Characteristics (2009)

The AWARE registry enrolled a broad group of real-world patients with chronic plaque psoriasis treated with alefacept in clinical practices across Canada.
Development of a soft gel cultivation method. (1991)

Mold mycelia grew on the surface of a soft gel medium containing 0.2-0.4% agar (soft gel cultivation) just as well as it did on conventional koji. Production and localization of several enzymes in soft gel cultivation were studied and compared with those in koji and liquid cultivations. The total activities of glutaminase, leucine aminopeptidase (LAP), neutral proteinase, and α-amylase produced from 1 g of wheat bran in soft gel cultivation were respectively 61%, 59%, 29%, and 24% of those in koji cultivation, and localization varied with the cultivation method. Glutaminase and LAP localized mostly in the intracellular and extracellular fractions in koji cultivation, but they did only in the whole-mycelial-mat fraction in soft gel cultivation. About 8% of proteinase and α-amylase activities were found in the intracellular fraction from koji cultivation, and 55% of proteinase activity and 37% of α-amylase activity were in the whole-mycelial-mat fraction in soft gel cultivation.
Nuclear magnetic resonance studies of methyl‐5, 6‐dicarboxy‐2‐norbornene derivatives (1971)

Abstract A simple procedure is provided for the quantitative analysis of Diels‐Alder adduct prepared from commercial methylcyclopentadiene and maleic anhydride by NMR spectra without further separation of its components. The adduct is considered as a mixture of endo norbornene derivatives (C n ), (D n ), (E) and (F n ) which are obtained from 1‐, 2‐ and 5‐methylcyclopentadiene and cyclopentadiene, respectively. The quantitative analysis of the adduct can be made on a basis of the ratio of the signal intensities of the olefinic protons in the adduct. The result shows that the adduct prepared under mild conditions mainly consists of three norbornene derivatives (C n ), (D n ) and (F n ), with a negligibly small amount of (E). When the adduct prepared under mild conditions is heated, it contains the exo isomers (Cx), (Dx) and (Fx). The ratio of the endo and the exo norbornene derivatives, i.e. ((C n ) + (D n ) + (F n )):((C x ) + (D x ) + (F x )), may be estimated from the signal intensities of the 5‐ and 6‐protons. As the result of the analyses of the adducts which are obtained by heating at different temperatures the adduct prepared under mild conditions, the mole fraction of 2‐methyl isomers (D n ) and (D x ), which is found to be 58 % in the adduct prepared at − 15°C, keeps on increasing with rising temperature and shows almost the same value, ∼86%, when heated above 150°C. Therefore, the equilibrium between 1‐methyl and 2‐methyl isomers does not change above 150°C. On the other hand, the isomerization from endo to exo isomers is not found below 110°C, and then exo isomers keep on increasing above 140°C.
Acoustic Behavior of Fractures under Static Stress (2001)

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Evaluation of the dose metric for acute lung inflammogenicity of fast-dissolving metal oxide nanoparticles (2016)

Although surface area metric was suggested as an appropriate dose metric for acute lung inflammation of NPs, it might not be effective for fast-dissolving NPs because they lose their reactive surface when dissolved in the phagolysosomes. Herein, we evaluated the dose metric for fast-dissolving NPs using a rat intratracheal instillation model. A panel of fast-dissolving NPs (CoO, CuO and ZnO) and their constituent metal ions (CoCl<sub>2</sub>, CuCl<sub>2</sub> and ZnCl<sub>2</sub>) were compiled and each compound was intratracheally instilled into the lungs of female Wistar rats at the same molar concentrations in the NP doses (40, 100 and 400 μg/rat). The toxicity endpoints including cytological and biochemical data in bronchoalveolar lavage fluid were evaluated at 24 h after instillation. To evaluate the dose metric, each toxicity endpoint was plotted against the instilled dose (mass or surface area) or the equivalent dose (mass or surface area) that was weighted by the ratio of specific dose-generated responses between metal chlorides. Dose-response curves of fast-dissolving NPs about percentage of granulocytes, lactate dehydrogenase levels and total protein levels showed similar pattern but slightly less potential than those of their respective metal chlorides. When each toxicity endpoint was plotted against the equivalent mass dose, three types of NPs showed more overlapping dose-response curves than other dose metrics. In conclusion, this study implies that the equivalent mass dose is an appropriate dose metric for fast-dissolving NPs and the main factor determining the slope of the dose-response curve is the intrinsic toxicity of the their constituent ions.
The Center for Systems Management to Launch First INCOSE Pre‐Certification Training Program (2005)

INSIGHT is the magazine of the International Council on Systems Engineering. It is published four times per year and features informative articles dedicated to advancing the state of practice in systems engineering and to close the gap with the state of the art. INSIGHT delivers practical information on current hot topics, implementations, and best practices, written in applications-driven style.
End-to-End Blocking Probability Approximations for Resource Management in Multi-Rate Loss Networks (1995)

Effective traffic control in multirate networks is vital, because a small increase in the carried traffic may significantly increase the operator&apos;s revenue and at the same time enhance the user&apos;s satisfaction. Therefore evaluation of end-to-end blocking probabilities and carried traffic when combining different routing and link allocation strategies is important. A broad spectrum of different routing and link allocation procedures is available in the literature; unfortunately most of the analytical models are either constrained by the network topology, or of high computational complexity. This paper (1) presents analytical and simulation results on a variety of combinations of routing and link allocation algorithms and (2) proposes an optimization model in which the revenue or carried traffic in multi-rate loss networks is optimized with respect to load sharing parameters or an optimal partitioning between bandwidth classes is found. With respect to routing we consider non-alternate, s...
The influence on the spine of leg-length discrepancy after femoral fracture (1983)

We investigated the spines of 15 patients who had significant leg-length inequality as a result of femoral shaft fractures sustained after skeletal maturity but below the age of 21 years. The patients were examined at least 10 years after fracture. The spines were studied clinically and radiographically before and after correction of leg-length inequality with a shoe-raise. Lateral spinal flexion was measured from radiographs. The lumbar scoliosis associated with the leg-length inequality was compensatory: after equalisation of leg-length the overall curve and the axial rotation were corrected completely. There was also an equal range of lateral flexion to either side after correction. Minor malalignments of the whole spine remained despite correction of the compensatory scoliosis, and within the lumbar spine correction of the scoliosis had not occurred equally at all levels. No patients complained of significant discomfort and neither structural abnormalities nor degenerative changes were seen on the radiographs.
Overhead of deoptimization checks in the V8 javascript engine (2016)

Just-in-time compilation for dynamic languages uses type speculation to generate optimized code for frequently executed code sections. However, even the high-performance code requires checks to ensure that assumptions made during code generation are not violated. If the assumptions are violated then the program reverts to executing unoptimized code. This process is called deoptimization, and the checks are called deoptimization checks. We analyzed the frequency of conditional deoptimization checks and the performance impact of the associated conditional branch using the V8 Javascript engine running the Octane benchmarks. Over half of the benchmarks have at least 5 checks per 100 instructions, and 1 benchmark has as many as 19 checks per 100 instructions. The performance impact of the checks varies significantly depending on the microarchitecture of the CPU that is running the code. On average the conditional branch used by the checks accounts for over 6.2% of the benchmark's dynamic instructions. Removing these checks provides only a 2.2% performance improvement when running on a high performance Intel CPU, but a 4.6% performance improvement on an Intel CPU optimized for low power consumption.
Targeting of Tumor Neovasculature with GrB/VEGF121, a Novel Cytotoxic Fusion Protein (2017)

Angiogenesis is a critical process in numerous diseases, and intervention in neovascularization has therapeutic value in several disease settings, including ocular diseases, arthritis, and in tumor progression and metastatic spread. Various vascular targeting agents have been developed, including those that inhibit growth factor receptor tyrosine kinases, blocking antibodies that interfere with receptor signal transduction, and strategies that trap growth factor ligands. Limited anti-tumor efficacy studies have suggested that the targeted delivery of the human pro-apoptotic molecule Granzyme B to tumor cells has significant potential for cancer treatment. Here, we review biological vascular targeting agents, and describe a unique vascular targeting agent composed of Granzyme B and the VEGF receptor ligand VEGF<sub>121</sub>. The fusion protein GrB/VEGF<sub>121</sub> demonstrates cytotoxicity at nanomolar or sub-nanomolar levels, excellent pharmacokinetic and efficacy profiles, and has significant therapeutic potential targeting tumor vasculature.
Influence of oxygen content on the characteristics of DBD plasma actuator (2015)

The aerodynamic performance of an AC powered dielectric barrier discharge (DBD) plasma actuator immersed in pure oxygen and also in O2 + noble gas mixtures is presented in terms of actuator's discharge structure and momentum coupling to the surrounding gas. At various gas pressures the impulse imparted to the freely-moving actuator body and its transient motion as a function of the applied voltage from 8-24 kV at f = 200 Hz is determined using laser interferometry. The present E/N results show that with increase of oxygen content the momentum coupling is better, especially in the negative species dominated forward discharge phase.
Liquid crystalline phases from polymer functionalised semiconducting nanorods (2008)

The orientation of semiconducting nanomaterials is a hot topic in optoelectronic applications. Liquid crystallinity offers the potential to orient inorganic anisotropic nanorods, if they can be solubilised sufficiently as realised by polymer functionalisation. In this work we functionalised TiO2, SnO2, ZnO and CdTe nanorods with PMMA, PS and PDEGMEMA (poly(diethylene glycol monomethyl ether) methacrylate) diblock copolymers containing anchor groupsvia grafting-to. The block copolymers were synthesised by RAFT polymerisation (PDI ≈ 1.2) via reactive ester diblock copolymers, which were functionalised later with anchor units polymer-analogously. The surface coverage of the nanorods (determined by TGA) is dependent on the block lengths and ratios and maximal coverage is found for short anchor unit blocks. Stable dispersions are obtained for these hairy rod hybrids and they form liquid crystalline phases at suitable concentrations in organic solvents as well as in oligomeric and polymeric matrices like oligo-PEG, oligo-PS and polymeric PDEGMEMA. Liquid crystalline textures are found in polarised microscopy images. Clearing temperatures were found to be between 60 and 230 °C depending on the length of the nanorods and the organic matrix.
Aortic Ball Variance: Diagnosis and Treatment (1970)

Increased incidences of acute valvular malfunction and of death due to changes in the silicone poppet of cardiac valve prostheses have been noted. Of the 47 long-term survivors of aortic replacement with the model 1000 series Starr-Edwards valve operated upon in a 1-year period beginning July 1, 1963, 40 patients have been available for follow-up. Of these, ball variance has been demonstrated by autopsy or reoperation in 30 (75%). Ball variance was noted at autopsy in 7 cases (18%) and was considered the cause of death in 5 (13%). The symptoms of ball variance are nonspecific and include fatigue, dyspnea on exertion, palpitation, dizzy spells, angina, and syncopal episodes. The diagnosis of aortic ball variance is based on the absence of the aortic opening sound; a consistently abnormal phonocardiogram or sound spectrogram, or both; recurrent embolic episodes; and late onset of aortic regurgitation or radiographic evidence of an abnormal barium-impregnated poppet, or both. Ball variance in the mitral prosthesis is also discussed.
Anti-thrombin antibodies induced by dengue virus with both anti-thrombotic and pro-fibrinolytic activities (2013)

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