gebhart/patrepeval huggingface dataset:
Mechanical lithotripsy of large common bile duct stones using a basket (1991)

Experience with the Olympus basket mechanical lithotriptor (BML-1Q) in crushing large common bile duct stones before their endoscopic removal is reported. From January 1988 to January 1990, 68 patients with common duct stones too large to be extracted by Dormia baskets or balloon catheters after sphincterotomy were treated with the BML system. The largest stones in each patient ranged from 1.0 to 4.9 cm in diameter. Fifty-seven patients required one session of lithotripsy, ten patients two sessions and one patient three sessions; 26 patients required further endoscopic extraction of stone fragments after successful lithotripsy. The stones were successfully crushed by the BML system and the ducts cleared in 55 patients (81 per cent). In 13 patients mechanical lithotripsy failed because the stones could not be engaged in the lithotriptor basket. In one patient the stone was crushed with the Soehendra lithotriptor, six patients were successfully managed by electrohydraulic lithotripsy through a 'mother and baby' endoscope, indwelling stents were inserted in four patients and two patients underwent surgery.
Taxonomic revision of the East Asian genus Scleropteroides Colonnelli, 1979 (Coleoptera, Curculionidae, Ceutorhynchinae) (2014)

The genus Scleropteroides Colonnelli, 1979 (Ceutorhynchinae: Scleropterini) was revised on the basis of detailed morphological observations. The genus was redefined to include three species from East Asia: S. hypocrita (Hustache, 1916) is redescribed and recorded from northeastern China and northern Korea for the first time; S. horridulus (Voss, 1958) is redescribed with new records from southern Korea; S. insularis Voss, 1971 was moved from synonymy with S. hypocrita to that with S. horridulus (syn. n.), and S. longiprocessus Huang & Yoshitake, sp. n. is described as new, sympatric with S. hypocrita in Japan. All the species are associated with woody Rubus species (Rosaceae). A key to species, habitus photographs, illustrations of important characters, and distribution maps are provided for each species.
Constructing and validating a new measure of ingroup identification. (2017)

In this study we constructed a scale that measures centrality, social, communal, andinterdependent identifi cation, and investigated the distinction between these four different typesof identifi cation with social groups. The general aim was to examine the psychometric propertiesof the newly designed Centrality, Social, Communal, and Interdependent Identifi cation Scale(CSCIIS) and to investigate whether differences in self-construal, relationship orientation,gender, and culture might predict each type of identifi cation. The results provided initial supportfor the validity and the reliability of the CSCIIS, revealed cross-cultural differences in ingroupidentifi cation, and supported predictions regarding the correlations between particular types ofrelationships orientation and particular types of identifi cation with social groups.
371. The constituents of natural phenolic resins. Part III. Synthesis of dehydro-“sulphite-liquors lactone” dimethyl ether and some observations on the structure of podophyllotoxin (1935)

R. D. Haworth, T. Richardson and G. Sheldrick, J. Chem. Soc., 1935, 1576 DOI: 10.1039/JR9350001576
Über das Elektronenstrahlschmelzen, die Verformung und die Rekristallisation von Niob und Tantal (1965)

Article Über das Elektronenstrahlschmelzen, die Verformung und die Rekristallisation von Niob und Tantal was published on May 1, 1965 in the journal International Journal of Materials Research (volume 56, issue 5).
Thin-film filters for a high resolution miniaturized spectrometer (2008)

A lightweight and compact spectrometer with spectral resolution in the order of 0.1 nm, in a spectral range from UV to NIR, can be implemented using a spectral pre-selection technique at the spectrometer entrance, through transmission variable filters. Such filters, based on thin-film optical coatings, have either a transmission peak or a transmission edge that moves along one direction of the filter surface. Depending on the spectrometer design, different configurations of the pre-selection device are possible. The operating spectral range (240-800 nm) is divided in a number of sub-ranges and in each of them the filter transmission peak, or edge, is displaced from the minimum to the maximum wavelength over a distance of few mm. Two cases are considered: a configuration with both a narrow-band transmission filter and a band-pass filter having a linear spatial variation and a configuration with an edge filter having a non-linear spatial variation. To obtain the required spatial profile of filter performance, a graded coating is deposited on a fused silica substrate, by r.f. sputtering with a moving mask. Details on filter requirements and fabrication technology are reported.
ChemInform Abstract: STABILITAET VON WASSER‐IN‐OEL‐EMULSIONEN ALS FUNKTION DER TEMPERATUR UND DER LAENGE DER HYDROPHILEN KETTE DES EMULGATORS (1970)

Abstract Untersucht werden Wasser‐in‐Öl‐Emulsionen des durch Polyoxyäthylennonylphenyläther stabilisierten Cyclohexan‐Wasser‐Systems.
Isolation of a novel arachidonic acid metabolite 3‐hydroxy‐5,8,11,14‐eicosatetraenoic acid (3‐HETE) from the yeast <i>Dipodascopsis uninucleata</i> UOFs‐Y128 (1991)

When arachidonic acid (AA) is added to the yeast Dipodascopsis uninucleata UOFS Y128, one of the major metabolites isolated and purified with the help of thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) is 3-hydroxy-5,8,11,14-eicosatetraenoic acid (3-HETE). The structure of this new AA metabolite was elucidated mainly by electron impact (EI) mass spectrometry (MS). Strikingly, the formation of this new metabolite was found to be inhibited by aspirin.
Obituary (Dr. SABURO_SUZUKI) (1988)

of Ohtsuma Women's University passed away on December 30th, 1987, at the age of sixty-seven.It is a great loss and sadness to all.He was a contributor to The Journal of Antibiotics and served effectively on the Editorial Board of this journal for twenty years.Those of us who knew him well will associate Saburo Suzuki with the personality of uncommon patience, gentleness and modesty.He was a quiet-spoken, thoughtful man, always striving for excellence, enthusiastic concern for the welfare of his colleagues, friends, and students, and sincere respect for elders.
The synthesis of <sup>14</sup>C‐labeled suicide inactivators of monoamine oxidase (1978)

Abstract N‐[3‐(2,4‐dichlorophenoxy)propyl]‐N‐methyl‐2‐propynylamine‐1‐ 14 C ( 14 C‐clorgyline, 1a ) and L‐N, α‐dimethyl‐N‐2‐propynyl‐1‐ 14 C‐phenethylamine ( 14 C‐L deprenyl, 1b ) were synthesized by the Mannich reaction of 2‐methyl‐3‐butyn‐2‐ol, 14 C‐formaldehyde, and secondary amines 3‐(2,4‐dichlorophenoxy)‐N‐methylpropylamine (2a) or L‐N, α‐dimethylphenethylamine ( 2b ) followed by KOH catalyzed elimination of acetone from the respective Mannich base 3a or 3b .
The Modelling and Prediction of the Influence of Building Vibration on the Dynamic Response of Elevator Ropes (2003)

A vibration model to investigate the influence of building lateral vibration on the dynamic response of hoist ropes in an elevator system is presented in this paper. This model describes the coupled lateral-longitudinal dynamic response of the ropes in terms of non-linear partial differential equations that accommodate the non-stationary nature of the system. Subsequently, a discrete model with quadratic and cubic non-linear terms describing the modal interactions in the system is derived. It is shown that the building sway results in a distributed inertial load acting upon the hoist ropes which in turn may lead to resonance and modal interactions between the lateral modes and the fundamental longitudinal mode.
Synthesis of 6-Substituted Purine N<sup>7</sup>-(2-Deoxy-β-D-Ribonucleosides) via Anion Glycosylation and Anomerization During the N<sup>7</sup>/N<sup>9</sup>-Glycosyl Transfer (1995)

Abstract The synthesis of the 7-(2-deoxy-β-D-erythro-pentofuranosyl)adenine (1b) as well as the corresponding hypoxanthine- and purine nucleosides 3 and 4 is described employing the stereoselective nucleobase anion glycosylation. The N7/N9-isomer distribution of the 6-substituted purine (2-deoxyribonucleosides) depends on 6-substituent. Glycosyl transfer of 8a resulted in anomerization and yielded a mixture of the anomeric 6-methoxypurine N9-(2-deoxy-D-ribonucleosides) 7a/7d. The preferred glycosylic bond conformation of purine N7-(2-deoxyribonucleosides) is anti.
Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases (2002)

Chronic obstructive pulmonary disease (COPD) is a common lung disease with cigarette smoking as the major etiological factor, but only 15% of smokers develop COPD. Destruction of lung elastin observed in COPD is mediated by many enzymes, including cysteine, serine, and matrix metalloproteinases (MMP). The contribution of these enzymes to the lung elastolytic load, released from alveolar macrophages collected from nonsmokers, healthy smokers, and COPD patients, was examined by radiolabeled elastin as substrate in the presence of specific enzyme inhibitors. The activity of MMP was further examined by zymography and Western blotting. COPD macrophages degraded more elastin than either of the other groups. Elastolysis was greatest in the initial 24 h. Through the 72-h culture period, the contribution to elastolysis of serine elastases decreased, MMP increased, and cysteine elastases remained constant. The increased release of elastolytic enzymes in COPD subjects may explain why some smokers develop COPD. This difference may be due to unknown susceptibility factors. Serine proteases play a significant role; however, other enzymes, particularly the MMP, deserve further investigation.
Conformational Dynamics and Allostery in Pyruvate Kinase (2016)

Pyruvate kinase catalyzes the final step in glycolysis and is allosterically regulated to control flux through the pathway. Two models are proposed to explain how Escherichia coli pyruvate kinase type 1 is allosterically regulated: the "domain rotation model" suggests that both the domains within the monomer and the monomers within the tetramer reorient with respect to one another; the "rigid body reorientation model" proposes only a reorientation of the monomers within the tetramer causing rigidification of the active site. To test these hypotheses and elucidate the conformational and dynamic changes that drive allostery, we performed time-resolved electrospray ionization mass spectrometry coupled to hydrogen-deuterium exchange studies followed by mutagenic analysis to test the activation mechanism. Global exchange experiments, supported by thermostability studies, demonstrate that fructose 1,6-bisphosphate binding to the allosteric domain causes a shift toward a globally more dynamic ensemble of conformations. Mapping deuterium exchange to peptides within the enzyme highlight site-specific regions with altered conformational dynamics, many of which increase in conformational flexibility. Based upon these and mutagenic studies, we propose an allosteric mechanism whereby the binding of fructose 1,6-bisphosphate destabilizes an α-helix that bridges the allosteric and active site domains within the monomeric unit. This destabilizes the β-strands within the (β/α)8-barrel domain and the linked active site loops that are responsible for substrate binding. Our data are consistent with the domain rotation model but inconsistent with the rigid body reorientation model given the increased flexibility at the interdomain interface, and we can for the first time explain how fructose 1,6-bisphosphate affects the active site.
Measurement of angle kappa and centration in refractive surgery (2012)

There is a growing body of evidence that emphasizes the consideration of angle kappa in refractive surgery. Ignoring angle kappa may sometimes result in decentered treatment and aggravation of visual symptoms. Compensation for angle kappa is important for optimal correction of refractive error by either laser ablation or IOLs, especially for hyperopes and any eyes with large angle kappa.
Combinatorial Library of Low Molecular‐Weight Organo‐ and Hydrogelators Based on Glycosylated Amino Acid Derivatives by Solid‐Phase Synthesis (2003)

A combinatorial approach for the synthesis of supramolecular gelators as new organic materials is described herein. In the course of the development of a convenient and flexible solid-phase synthesis of the artificial glycolipids, some of these compounds were accidentally found to act as low molecular-weight gelators toward organic solvents. Using this combinatorial solid-phase synthesis of glycosylated amino acetates, screening and optimization of low molecular-weight organo/hydro-gelators were efficiently carried out. We found that an N-acetyl-galactosamine-appended amino acid ester (GalNAc-aa) efficiently gelates a broad spectrum of organic solvents. More interestingly, some GalNAc-aa derivatives displayed an excellent hydrogelation capability. Transmission electron microscopy, scanning electron microscopy, confocal laser scanning microscopy, and FT-IR were used for characterization of the gel structure. It is indicated that supramolecular fibers supported by strong hydrogen-bonding networks are entangled so that the resulting spaces can immobilize a number of solvent molecules effectively. In addition, the supramolecular hydrogel consisting of GalNAc-suc-glu(O-methyl-cyc-pentyl)(2) is stable even under high salt concentrations probably due to its nonionic character and as a result, a native protein is successfully entrapped in the gel matrix without denaturation.
beta 0 thalassemia, a nonsense mutation in man. (1979)

We determined the complete nucleotide sequence of the 5' noncoding region and the first 74 amino acids of the nonfunctional beta-globin mRNA in a patient with homozygous beta 0 thalassemia. We identified the molecular defect as a single nucleotide substitution in the coding region of the mRNA. At the position corresponding to amino acid 17, replacement of an adenine by a uracil changes the triplet AAG, which codes for lysine in the normal beta chain, to an amber termination codon, UAG. This type of beta 0 thalassemia represents an example of a nonsense mutation in man.
Interactions Between Phospholamban and β-Adrenergic Drive May Lead to Cardiomyopathy and Early Mortality (2001)

The unique interaction between phospholamban and increased adrenergic drive, elucidated herein, provides the first evidence that compensatory increases in catecholamine stimulation can, even in the absence of preexisting heart failure, be a primary causative factor in the development of cardiomyopathy and early mortality.
Enzymatic Properties of Serine 93 Mutants of RNase Rh from Rhizopus niveus. A Trial to Alter the Base Preference of RNase Rh (2005)

In order to investigate the effects of mutation of Ser93, a component of base recognition site (B2 site) of a base non-specific RNase from Rhizopus niveus, we prepared 10 mutant enzymes at this position, S93A, S93V, S93F, S93T, S93G, S93D, S93N, S93E, S93Q and S93R, and their enzymatic activities towards RNA and 16 dinucleoside phosphates were measured. Enzymatic activities of the mutant enzymes towards RNA were between 3.5-75% of the native enzyme. From the rates of hydrolysis of 16 dinucleoside phosphates by the mutant enzymes, we estimated the base preference of B1 and B2 base recognition sites. The results indicated that mutation of Ser93 to Phe, Thr, Glu. Gln and Arg caused the B2 site of the enzymes to more cytosine base preference and Asp and Asn substitution caused more uracil base preference. The results suggested that we are able to construct an enzyme that preferentially cleaves internucleotidic linkage at the 5'-side of cytidine or uridine. The results seem able to convert a base non-specific RNase to a base specific one.
Animal Metabolism of Insecticides, Bovine Metabolism of Organophosphorus Insecticides. Metabolic Fate of O,O-Dimethyl O-(2,4,5-trichlorophenyl) Phosphorothioate in Rats and a Cow (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnimal Metabolism of Insecticides, Bovine Metabolism of Organophosphorus Insecticides. Metabolic Fate of O,O-Dimethyl O-(2,4,5-trichlorophenyl) Phosphorothioate in Rats and a CowF. W. Plapp and J. E. CasidaCite this: J. Agric. Food Chem. 1958, 6, 9, 662–667Publication Date (Print):September 1, 1958Publication History Published online1 May 2002Published inissue 1 September 1958https://pubs.acs.org/doi/10.1021/jf60091a002https://doi.org/10.1021/jf60091a002research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the use of autoregressive time series in the modelling of Doppler signals for diagnostic purposes (1983)

Doppler instruments are widely used in the diagnosis of vascular diseases: however, the physician generally makes the diagnosis from personal experience, and by subjective evaluation of some quantities related to blood flow (e.g., maximum or mean frequency envelope, or zero-crossing density). In order to obtain more objective criteria, methods based on either spectrum analysis, or on Laplace or other orthogonal transforms have been proposed. An alternative approach to the diagnosis of vascular alterations is proposed, which relies on the modelling of flow signals by means of autoregressive time series. The parameters of the autoregressive model have been used for the detection of alterations. The basis of the method is discussed and some preliminary results are reported.
ChemInform Abstract: Synthetic Angucyclines. Part 2. First Total Synthesis of (.+‐.)‐ Rabelomycin. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in mice (2011)

Apolipoprotein (apo) E4 is the major known genetic risk factor for Alzheimer's disease (AD). We have shown in vitro and in vivo that apoE4 preferentially undergoes aberrant cleavage in neurons, yielding neurotoxic C-terminal-truncated fragments. To study the effect of these fragments on amyloid-β (Aβ) clearance/deposition and their potential synergy with Aβ in eliciting neuronal and behavioral deficits, we cross-bred transgenic mice expressing apoE3, apoE4, or apoE4(Δ272-299) with mice expressing human amyloid protein precursor (APP) harboring familial AD mutations (hAPP(FAD)). At 6-8 mo of age, hAPP(FAD) mice expressing apoE3 or apoE4 had lower levels of hippocampal Aβ (94% and 89%, respectively) and less Aβ deposition (89% and 87%) than hAPP(FAD) mice without apoE, whereas hAPP(FAD) mice expressing mouse apoE had higher Aβ levels. Thus, human apoE stimulates Aβ clearance, but mouse apoE does not. Expression of apoE4(Δ272-299) reduced total Aβ levels by only 63% and Aβ deposition by 46% compared with hAPP(FAD) mice without apoE. Unlike apoE3 and apoE4, the C-terminal-truncated apoE4 bound poorly with Aβ peptides, leading to decreased Aβ clearance and increased Aβ deposition. Despite their lower levels of Aβ and Aβ deposition, hAPP(FAD)/apoE4(Δ272-299) mice accumulated pathogenic Aβ oligomers and displayed neuronal and behavioral deficits similar to or more severe than those in hAPP(FAD) mice. Thus, the C-terminal-truncated apoE4 fragment inefficiently clears Aβ peptides and acts in concert with low levels of Aβ to elicit neuronal and behavioral deficits in mice.
Knowledge-Based Linguistic Annotation of Digital Cultural Heritage Collections (2009)

A method for automatically annotating objects in digital cultural heritage collections uses structured vocabulary concepts and their metadata schema roles.
A Review (1978)

Intra-abdominal sepsis that involves multiple aerobic and anaerobic bacteria derived from the colonic flora was studied in Wistar rats to determine the relative roles of various microbial species. The rats challenged with pooled colonic contents showed a biphasic disease. Initially, there was acute peritonitis, Escherichia coli bacteremia, and high mortality. In rats that survived this acute peritonitis stage, intra-abdominal abscesses developed, and anaerobic bacteria were the preponderant organisms. Subsequent experiments showed that antibiotics directed against coliforms prevented mortality, whereas agents active against anaerobes reduced the incidence of abscesses. Challenges with Escherichia coli alone produced bacteremia and death, whereas pure cultures of Bacteroides fragilis caused intra-abdominal abscesses. These observations suggest that both coliforms and anaerobes are important pathogens in intra-abdominal sepsis, although the different types of microbes appear to play distinctive roles in the sequence of pathological events.
ChemInform Abstract: SYNTHESIS OF ALKYL 4‐HYDROXY‐2‐ALKYNOATES (1980)

Abstract Propiolsäureester (I) liefern mit Butyllithium die Lithioverbindungen (II), die mit Oxo‐Verbindungen zu Addukten (III) führen.
ChemInform Abstract: Structures of Novel Macrocyclic Dipyridylmethaneamides. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Estimation of the Quantum Yield in the Candoluminescence Process by Low Energy H+ Ion Bombardment (1978)

The luminescent quantum yields for and phosphors under hydrogen ion beam excitation have been determined at 300°K as a function of beam energy in the range 1–8 keV. The dependence of the yields on the energy of the H+ bombarding ions follows an exponential relation and the yields extrapolated to zero ion energy are for and for .
Phenomena of Cathode Sputtering (1924)

When metal is deposited cathodically upon a glass plate a film is found upon the side of the plate away from the cathode. In the study of this deposit both alternating and direct potentials were employed. An attempt to increase the deposit by various reflecting surfaces gave negative results. A possible explanation of the phenomenon is offered, based upon the assumption that the metallic particles receive a positive charge after leaving the cathode. An attempt to sputter non-conductors in the form of metallic oxides gave negative results.