gebhart/patrepeval huggingface dataset:
LACK OF CORRELATION OF COPY NUMBER OF HLA DQA1A*05 DQB1*02 AND TISSUE TRANSGLUTAMINASE LEVELS IN UNTREATED CELIAC DISEASE (2005)

Background: Celiac Disease is an autoimmune disorder of the small intestine characterized by intolerance to gluten. More than 90% of the patients with celiac disease have the human leukocyte antigen DQA1*05 DQB1*02. A gene dosage effect has been proposed for this high-risk genotype. In CD, there is an autoimmune response to the enzyme tissue transglutaminase, causing the production of immunoglobulin A autoantibodies, which are quantitative and resolve with improvement of intestinal inflammation after adherence to a gluten-free diet. Methods: Blood samples were collected from relatives of patients with known celiac disease as part of a family study to identify genes for celiac disease. These patients were screened for immunogloglobulin A endomysial antibodies. Positive sera were then evaluated for quantitative levels of immunoglobulin A tissue transglutaminase antibodies and HLA genotyping was performed. Results: One hundred sixteen family members were found to be positive for immunoglobulin A endomysial antibodies. Tissue transglutaminase levels for this group had a mean of 111 (±SD 93) with a range of 4-258. There was no correlation between IgA tTG levels and age or sex of the patients. Twelve patients had no copies of DQA1*05DQB1*02,82 had 1 copy, and 22 had 2 copies. The means for IgA tTG Ab levels for the 3 groups were (1) zero copies, mean = 129 Units (2) one copy, mean = 111 units (3) two copies, mean = 100 units. There were no statistical differences between the IgA tTG Ab levels in the 3 groups or when or when the presence of the DQB1*02 genotype alone was evaluated. Conclusion: HLA genotype, although it is strongly correlated with CD and does not correlate with the level of IgA tTG Ab.
AI Planning for Tele-operated Robotic Network Slice Reconfiguration (2021)

Tele-operated and tele-presence robotics have been gaining industrial traction due to the advantages of remote operation and flexibility. Generating network slices for Industry 4.0 tele-operation has traditionally been a static process with redundant network resources and spectrum over provisioning. However, this adds constraints on scalability, resource provisioning and costs in dedicated industrial networks. In this work, we explore the use of Artificial Intelligence Planning techniques to jointly plan, schedule and reconfigure robotic tasks in conjunction with appropriate network slicing. Through detailed analysis of resources and process timelines involved in slice provisioning and scaling, we demonstrate provisioning of appropriate slices with respect to robotic tasks. This is evaluated over a case study involving tele-operated robots for remote inspection in Industry 4.0 manufacturing. The system is able to reconfigure tasks in an appropriate manner to reduce end-to-end processing delays, while using just a fraction of network resources.
Reverse‐flow operation for application of imperfectly immobilized catalysts (2003)

Abstract A reverse‐flow packed‐bed reactor used to solve the problem of leaching from immobilized homogeneous catalysts was studied. Product‐to‐catalyst ratios (PCRs) for a reverse‐flow reactor (RFR) and a conventional batch reactor with catalyst reuse were compared theoretically and numerically. In the ideal case without band broadening in the RFR it is possible to completely eliminate the limit on PCR due to leaching, but in practice, band broadening, caused by kinetic and dispersion effects, cannot be avoided. Nonetheless, numerical experiments showed numerous cases with much higher PCRs for the RFR than for batch operation with catalyst reuse. Therefore, an RFR may be a successful solution in cases when catalyst leaching is too high for using batch operation with catalyst reuse. The design and operation of a suitable RFR are also discussed.
Magnesiumphosphide – Synthese und Struktur von [Mg(PHPh)2(tmeda)] (1987)

Anwendung als PR-Überträger könnten die neuen anorganischen Magnesium-Reagentien [Mg(PHPh)2]∞ und die kristalline, monomere Titelverbindung 1 finden. Sie wurde durch Monometallierung von PhPH2 mit dem vielfältig nutzbaren Reagens nBusBuMg und Zusatz von TMEDA in hoher Ausbeute hergestellt. In 1 sind die MgP-Abstände gleich, die MgPC-Winkel aber nicht.
Unusual Intranuclear Inclusions in Malignant Fibrous Histiocytoma: Presence in Primary Tumor (1982)

We describe previously unreported intranuclear inclusions in 2 cases of malignant fibrous histiocytoma. The inclusions were found in 2-10% of the tumor cells removed from the patients and in 2-10% of the cells examined in tumor tissue xenotransplanted in nude mice. By stereo electron microscopy the inclusions are closely packed undulating fibrils 18-23 nm in diameter. They are sometimes associated with fibrillary bodies. They closely resemble the inclusions reported in some animals inoculated with serum from patients with non-A non-B hepatitis; however, their nature at present is unknown.
Cover Picture: The Chemistry of Wine Polyphenolic <i>C</i>‐Glycosidic Ellagitannins Targeting Human Topoisomerase II (Chem. Eur. J. 22/2005) (2005)

The chemistry of oak‐derived NHTP‐bearing C ‐glycosidic ellagitannins found in wine is reported by S. Quideau et al. in their Full Paper on page 6503 ff. These natural products are extracted by the wine solution during aging in barrels and have the capability to combine covalently by means of substitution reactions with a variety of grape‐derived nucleophilic species. The condensation products thus obtained can evidently contribute to the modulation of wine organoleptic properties, as well as possessing pharmacologically relevant activities.
Inhibition of GSK3 by Wnt signalling – two contrasting models (2011)

The key read-out of Wnt signalling is a change in the transcriptional profile of the cell, which is driven by β-catenin. β-catenin levels are normally kept low by a phosphorylation event that is mediated by glycogen synthase kinase 3 (GSK3, α- and β-isoforms), which targets β-catenin for ubiquitylation and proteasomal degradation. Wnt blocks this phosphorylation event, thereby allowing β-catenin to accumulate and to co-activate transcription in the nucleus. Exactly how Wnt inhibits GSK3 activity towards β-catenin is unclear and has been the focus of intensive research. Recent studies on the role of conserved PPPSPxS motifs in the cytoplasmic tail of low-density lipoprotein receptor-related protein (LRP, isoforms 5 and 6) culminated in a biochemical model: Wnt induces the phosphorylation of LRP6 PPPSPxS motifs, which consequently access the catalytic pocket of GSK3 as pseudo-substrates, thus directly blocking its activity against β-catenin. A distinct cell-biological model was proposed more recently: Wnt proteins induce the uptake of GSK3 into multivesicular bodies (MVBs), an event that sequesters the enzyme away from newly synthesised β-catenin substrate in the cytoplasm, thus blocking its phosphorylation. This new model is based on intriguing observations but also challenges a body of existing evidence, so will require further experimental consolidation. We shall consider whether the two models apply to different modes of Wnt signaling: acute versus chronic.
The i3d Shade Matching Technique: A Case Report (2017)

Objectives: In direct composite restorations, successful shade matching is considered as one of the most difficult
 task to accomplish. It is based on a subjective comparison between a shade tab and the natural tooth and as direct
 composite restorations are realized within one single appointment, no try-in is possible. Therefore the search for a
 reliable shade matching procedure is still going on.
Materials and Methods: Based on the fact that composite shade is thickness-dependent and that a natural
 tooth is built up of enamel and dentin with individual 3D thicknesses, a novel shade matching technique was developed
 respecting the natural three-dimensional structure of the tooth to be reproduced by the restorative composite material.
 CBCT data of an upper central incisor were converted into stl 3D files and a pair of 3D printed molds was acquired.
 One represented the negative of the root and the dentin core and the other one represented the negative of the enamel
 complex. By using these molds, an individual 3D shade tab perfectly reproducing the natural tooth morphology was
 fabricated out of pre-selected composite materials and used for shade comparison with a fractured upper central incisor.
Results: The preoperative ΔE value of approximately 3.46 of the custom shade tab-tooth has decreased into
 a postoperative ΔE value of 1.96. The vertical L* axis represented by Lightness made a significant positive difference
 (-3.07 to -1.78) when dentin material was modified while maintaining the same initial three-dimensional structure of the
 tooth to be reproduced, in both the custom shade tab-tooth and in the final restoration.
Conclusions: The proposed method significantly improved the shade matching of a direct composite restoration
 within one appointment. In the future, the i3D technique may be also used for 3D printed composite restorations and for
 the development of more aesthetic composite materials as well.
International Conference On Information Technology: Coding And Computing (2001)

Conference proceedings front matter may contain various advertisements, welcome messages, committee or program information, and other miscellaneous conference information. This may in some cases also include the cover art, table of contents, copyright statements, title-page or half title-pages, blank pages, venue maps or other general information relating to the conference that was part of the original conference proceedings.
A Test for Transvection in Plants: DNA Pairing May Lead to <i>trans</i>-Activation or Silencing of Complex Heteroalleles in Tobacco (2001)

To study whether DNA pairing that influences gene expression can take place in somatic plant cells, a system designed to mimic transvection was established in transgenic tobacco. Pairing was evaluated by testing whether an enhancerless GUS gene on one allele could be activated in trans by an enhancer on the second allele. The required heteroalleles were obtained at four genomic locations using Cre-lox-mediated recombination. In one transgenic line, elevated GUS activity was observed with the heteroallelic combination, suggesting that trans-activation occurred. Conversely, when the unaltered allele was homozygous, GUS activity dropped to hemizygous levels in a silencing phenomenon resembling dosage compensation. Double-stranded GUS RNAs or small GUS RNAs indicative of RNA-based silencing mechanisms were not detected in plants displaying reduced GUS activity. These results suggested that a transgene locus capable of pairing, as revealed by trans-activation, could also become silenced in an RNA-independent manner, thus linking DNA pairing and gene silencing. The transgene locus was complex and comprised an inverted repeat, which possibly potentiated allelic interactions. The locus was unable to trans-activate transgenes at ectopic sites, further implicating allelic pairing in the transvection effects.
An interlaboratory study to determine the presence of human papillomavirus DNA in esophageal carcinoma from China (1999)

Esophageal-carcinoma samples originating from the high-incidence area of China were tested in 2 different laboratories, each using a different degenerate PCR approach. Results confirmed the notion that none of the PCR approaches available for HPV-DNA detection today, is optimal for detecting all known HPV types at equal sensitivity and specificity. In combining results obtained in both laboratories, HPV DNA was demonstrated in 20/117 (17.1%) esophageal-carcinoma samples analyzed. HPV DNA was detected in 3/70 (4.3%) diagnostic biopsies, 7/23 (30.4%) surgical specimen and 10/24 (41.6%) cytological scrapings originating from the entire surface of the esophagus. Mucosotropic HPV types were present in 7/117 (6%) samples, only 3 being of the high-risk types (HPV 16, 18, 33). Other mucosal types found were HPV 6, 11, 13, 53 and 54. Cutaneous HPV types were present in 14/117 (12.0%) samples. HPVs 20 and 38 were present in 3 (2.6%) of the total samples and, in each case, together with another HPV type within one lesion. Two putative new HPV types, DL347 and DL 369, were identified.
Intradural Invasion of Chordoma: Two Case Reports (2002)

Chordomas are rare tumors of the central nervous system and primarily occur in the extradural space. We report two patients with intracranial chordomas located in the region of the clivus that invaded the prepontine cisterns. The patients, 45 and 62 years old, had histories of cranial neuropathies and headache, respectively. Petrosal approaches were performed in both with radical resection of the tumors. Anatomopathological studies confirmed the diagnosis of chordoma. The symptoms of both patients resolved, and they have had no recurrence after 18 months of follow-up. Intradural chordomas or extradural chordomas that invade the intradural space are difficult to differentiate from ecchordoses physaliphorae, a non-neoplastic entity with similar radiological features. MBI-1 studies were therefore performed to confirm the diagnosis of chordoma. The differential diagnosis for these two entities, the different modalities of treatment, and prognosis are reviewed.
Dynamic radial projection MRI of inhaled hyperpolarized <sup>3</sup>He gas (2003)

A radial projection sliding-window sequence has been developed for imaging the rapid flow of (3)He gas in human lungs. The short echo time (TE) of the radial sequence lends itself to fast repetition times, and thus allows a rapid update in the image when it is reconstructed with a sliding window. Oversampling in the radial direction combined with angular undersampling can further reduce the time needed to acquire a complete image data set, without significantly compromising spatial resolution. Controlled flow phantom experiments using hyperpolarized (3)He gas exemplify the temporal resolution of the method. In vivo studies on three healthy volunteers, one patient with chronic obstructive pulmonary disease (COPD), and one patient with hemiparalysis of the right diaphragm demonstrate that it is possible to accurately resolve the passage of gas down the trachea and bronchi and into the peripheral lung.
Upconversion: Imaging with Planar and Spherical Pump Beams (1970)

The imaging properties of nonlinear image upconverters with planar and spherical pump beams are discussed. We show the applicability of the fourier transform formalism and holographic analogy to the spherical pump beam case. Experimental results of upconversion with a spherical pump beam are presented and discussed.
Quasiclassical cross sections for the H+H2 (0, 0) →H+H2 reaction: Comparison of the Siegbahn–Liu–Truhlar–Horowitz and the Porter–Karplus potential surfaces (1979)

Integral and differential cross sections are calculated using the Porter–Karplus semiempirical potential and the Siegbahn–Liu–Truhlar–Horowitz analytic potential. (AIP)
Supporting Material, Supporting Figures S1-S4, Supporting Tables S1-S6 from Polyclonal symbiont populations in hydrothermal vent tubeworms and the environment (2019)

Horizontally transmitted symbioses usually house multiple and variable symbiont genotypes that are acquired from a much more diverse environmental pool via partner choice mechanisms. However, in the deep-sea hydrothermal vent tubeworm <i>Riftia pachyptila</i> (Vestimentifera, Siboglinidae), it has been suggested that the <i>Candidatus</i> Endoriftia persephone symbiont is monoclonal. Here, we show with high-coverage metagenomics that adult <i>R. pachyptila</i> house a polyclonal symbiont population consisting of one dominant and several low-frequency variants. This dominance of one genotype is confirmed by multilocus gene sequencing of amplified housekeeping genes in a broad range of host individuals where three out of four loci (<i>atpA, uvrD</i> and <i>recA</i>) revealed no genomic differences, while one locus (gyrB) was more diverse in adults than in juveniles. We also analysed a metagenome of free-living Endoriftia and found that the free-living population showed greater sequence variability than the host-associated population. Most juveniles and adults shared a specific dominant genotype, while other genotypes can dominate in few individuals. We suggest that although generally permissive, partner choice is selective enough to restrict uptake of some genotypes present in the environment.
The Preparation of Ipns of Polystyrene-Polyethylene and Poly(Butyl Methacrylate)-Polyethylene and Their Dynamic Mechanical Behavior (1990)

Abstract IPNs based on polyethylene and vinyl polymers were prepared according to a new procedure. We studied the dynamic mechanical behavior of two series of IPNs: polystyrene (PS)-polyethylene (PE) and poly(butyl methacrylate) (PBMA)-PE at the frequency ω = 1 Hz and in the temperature region from −50 to 200°C. Temperature dependences of the components of the dynamic modulus of elasticity G' and G" of the networks PS and PBMA have shapes typical of amorphous networks; the corresponding dependences of pure PE show, however, features typical of a semicrystalline polymer. IPNs of the system PS/PE show two-phase behavior. At T < 110°C, PE functions as a plasticizer. In the system PBMA/PE, better miscibility of components is seen, and PE exerts a reinforcing effect on the mechanical behavior over the whole temperature region. In both systems, network density increases with increasing PE content in IPNs. Better homogeneity and a slight increase in the network density of IPNs with PBMA/PE in comparison to PS/PE networks are probably caused by a greater number of grafted PBMA chains in the PE network compared to the PS network.
Expression of connexin 30 inXenopus embryos and its involvement in hatching gland function (2000)

Connexins are a family of proteins that assemble to form gap junction channels. Cell-cell communication through gap junctions mediates many important events in embryogenesis, including limb patterning, lens physiology, neuronal function, left-right asymmetry, and secretion from gland tissue. We studied the expression of connexin 30 (Cx30) in the Xenopus embryo and find that it is expressed in the developing hatching gland and pronephros. To determine whether its expression plays a functional role in the activity of the hatching gland, we exposed pre-hatching embryos to drugs that block gap junctional communication. This resulted in a continuation of normal growth and development but specifically abolished hatching. The treatment did not affect Cx30 or Xenopus hatching enzyme transcription, suggesting a post-transcriptional effect on Cx30 gap junctions. We conclude that junctional communication, possibly mediated by Cx30, is involved in secretion of hatching enzyme in Xenopus.
Potential lubricants for continuous casting of steel: polyol esters of partially hydrogenated soybean acids (1972)

Abstract In the past decade continuous casting of steel into billets and slabs without going through the ingot stage has drawn widespread attention in the steel industry. Mold lubrication is vital to continuous casting to prevent sticking. Approximately 50% of this operation uses a vegetable oil lubricant, primarily rapeseed oil. Trimethylolethane, trimethylolpropane, trimethylolbutane and pentaerythritol esters of partially hydrogenated soybean fatty acids, derived from commercially hydrogenated soybean oils, have been readily prepared in good yields. Preliminary measurements of viscosities, smoke, flash and fire points of these polyol esters indicate that they are possible candidates for use as lubricants in the continuous casting of steel.
A Pilot Study of Pro-Urokinase in the Treatment of Deep Vein Thrombosis (1994)

Safety and efficacy of the thrombolytic agent pro-urokinase (pro-UK) in the treatment of deep vein thrombosis of the lower limbs (DVT) have been investigated in an open, uncontrolled, pilot study. Fifteen patients were infused with 800.000 IU (5 mg)/h of pro-UK over 24 h (120 mg), together with unfractionated heparin adjusted to maintain the activated partial thromboplastin time between 1.5 and 2.5 times the basal value. Efficacy was assessed comparing venographic changes in the 11 evaluable limbs before and after pro-UK infusion. The Marder score decreased from a median pre-thrombolysis value of 28 (range 4-40) to 16 (3-38) (p < 0.05). One major hemorrhagic event (retroperitoneal bleeding 4 days after the end of the pro-UK infusion) occurred. Fibrinogen, alpha 2-antiplasmin and plasminogen significantly decreased from baseline values after 12 and 24 h, fibrin(ogen) degradation products significantly increased. Changes in hemostasis parameters were unrelated to thrombolytic efficacy. The results of this pilot study indicate that pro-UK is thrombolytic in DVT and that it can be administered simultaneously with conventional heparin treatment.
Magnetic Ordering in the Rare-Earth Hexaborides (1968)

Magnetic ordering in the rare-earth hexaborides has been studied by a variety of methods, and a clear correlation with the presence of conduction electrons has been found.
ChemInform Abstract: Dactylocyclines: Novel Tetracycline Glycosides Active Against Tetracycline‐Resistant Bacteria. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The importance of pre-freeze equilibration of glycerol in cryopreservation of human spermatozoa and the biochemical conversion of glycerol. (1993)

Overall best cryopreservation was obtained at 37 degrees C with 5% glycerol and 30 minutes' prefreeze incubation. Labeled glycerol was incorporated into both polar and nonpolar metabolites. Two chromatographic peaks were found associated with the spermatozoa, and one peak was found in the incubation medium.
A comparison between HfO2/Al2O3 nano-laminates and ternary HfxAlyO compound as the dielectric material in InGaAs based metal-oxide-semiconductor (MOS) capacitors (2016)

We compare the electrical properties of HfO2/Al2O3 nano-laminates with those of the ternary HfxAlyO compound in metal oxide semiconductor (MOS) capacitors. The dielectrics were deposited by atomic layer deposition on InGaAs. Water, ozone, and oxygen plasma were tested as oxygen precursors, and best results were obtained using water. The total dielectric thickness was kept constant in our experiments. It was found that the effective dielectric constant increased and the leakage current decreased with the number of periods. Best results were obtained for the ternary compound. The effect of the sublayer thicknesses on the electrical properties of the interface was carefully investigated, as well as the role of post-metallization annealing. Possible explanations for the observed trends are provided. We conclude that the ternary HfxAlyO compound is more favorable than the nano-laminates approach for InGaAs based MOS transistor applications.
Preparation of x-ray lithography masks using a tungsten reactive ion etching process (1982)

High-resolution x-ray lithography masks which use a tungsten absorbing layer were fabricated on polyimide support membranes. The tungsten was patterned with a reactive ion etching process. 70-nm lines and spaces have been replicated in polymethylmethacrylate (PMMA) using carbon K x rays. The process should allow high-resolution, high-contrast masks to be made for any wavelength.