gebhart/patrepeval huggingface dataset:
CD40 Ligand Trimer and IL-12 Enhance Peripheral Blood Mononuclear Cells and CD4+ T Cell Proliferation and Production of IFN-γ in Response to p24 Antigen in HIV-Infected Individuals: Potential Contribution of Anergy to HIV-Specific Unresponsiveness (2000)

It has been suggested that CD4+ T cell proliferative responses to HIV p24 Ag may be important in the control of HIV infection. However, these responses are minimal or absent in many HIV-infected individuals. Furthermore, while in vitro and in vivo responses to non-HIV recall Ags improve upon administration of highly active antiretroviral therapy, there does not appear to be a commensurate enhancement of HIV-specific immune responses. It is possible that CD4+ p24-specific T cells are deleted early in the course of infection. However, it is also possible that a discrete unresponsiveness, or anergy, contributes to the lack of proliferation to p24. To evaluate the possible contribution of unresponsiveness to the lack of CD4+ T cell proliferation to p24 in HIV-infected individuals, we attempted to overcome unresponsiveness. CD40 ligand trimer (CD40LT) and IL-12 significantly increased PBMC and CD4+ T cell proliferative responses to p24 Ag in HIV-infected, but not uninfected, individuals. No increase in proliferative response to CMV Ag was observed. CD40LT exerted its effect through B7-CD28-dependent and IL-12- and IL-15-independent mechanisms. Finally, the increase in proliferation with CD40LT and IL-12 was associated with an augmented production of IFN-gamma in most, but not all, individuals. These data suggest the possible contribution of HIV-specific unresponsiveness to the lack of CD4+ T cell proliferation to p24 Ag in HIV-infected individuals and that clonal deletion alone does not explain this phenomenon. They also indicate the potential for CD40LT and IL-12 as immune-based therapies for HIV infection.
A potential killer yeast to control secondary fermentation in vegetables (2017)

A total of 11 killer yeasts were studied with the aim of finding a yeast strain that could be added to a lactic starter for the production of fermented vegetables. Growth and production of toxins by the killer yeasts were first analyzed in Yeast and Mold broth (YM) at two pH levels and in the presence or absence of organic acids. All killer yeasts were sensitive to those acids in acidified media (pH 3.5). Two of them were selected for further analysis in a vegetable juice medium (VJM). Killer activities against two target yeasts (Saccharomyces unisporus Y-42 and Saccharomyces bayanus Y-43) previously isolated from spoiled fermented vegetables were then determined using well diffusion assay. Killer yeasts were grown on VJM using variable conditions; 3 temperatures, 5 salt concentrations and 5 pH levels. Fungicidal properties and synthesis of killer factors are strongly dependant on growth conditions as well as on the killer yeast strain used. Production of killer toxins by Hansenula anomala ATCC 36903 was optimal when incubated at 20°C to 30°C in VJM having a pH range between 3.5 to 4.5 and supplemented with sodium chloride at concentration of 2 to 4%. Those results suggest that Hansenula anomala ATCC 36903 could be a suitable addition to a lactic starter to help control secondary fermentation in fermented vegetables.
QUANTUM DOT DEVICES AND QUANTUM-DOT CELLULAR AUTOMATA (1999)

Abstract We discuss novel nanoelectronic architecture paradigms based on cells composed of coupled quantum dots. Boolean logic functions may be implemented in specific arrays of cells representing binary information, the so-called Quantum-Dot Cellular Automata (QCA). Cells may also be viewed as carrying analog information, and we outline a network-theoretic description of such Quantum-Dot Nonlinear Networks (Q-CNN). In addition, we discuss possible realizations of these structures in a variety of semiconductor systems (including GaAs/AlGaAs, Si/SiGe, and Si SiO 2 ), rings of metallic tunnel-junctions, and candidates for molecular implementations.
UML and C++: A Practical Guide to Object-Oriented Development (1997)

From the Publisher:
If you are interested in learning object-oriented technology using UML (Unified Modeling Language) and C++, then this guide from two leading software developers at Bell Laboratories of Lucent Technologies and ATT teaches the professional to make and trade off decisions to meet business needs; explains the differences among object-oriented analysis, object-oriented design, and object-oriented programming; provides a strategy for employing all the steps of object-oriented technology; fully worked case study that takes the reader through the entire development process; every concept is introduced with an example.
Modeling coping behavior in virtual humans (2003)

This article builds on insights into how humans cope with emotion to guide the design of virtual humans. Although coping is increasingly viewed in the psychological literature as having a central role in human adaptive behavior, it has been largely ignored in computational models of emotion. In this paper, we show how psychological research on the interplay between human emotion, cognition and coping behavior can serve as a central organizing principle for the behavior of human-like autonomous agents. We present a detailed domain-independent model of coping based on this framework that significantly extends our previous work. We argue that this perspective provides novel insights into realizing adaptive behavior.
Concert Gan’ A Capella – Couleurs Vocales (2013)

La chorale « Couleurs Vocales » a presente son recital de fin d'annee en association avec la chorale « Gan' A Capella » a l'eglise de Charroux, dans l'Allier, le dimanche 9 juin 2013 a 16 h. L'an dernier, la chorale de Gannat avait ete recue a Vic Le Comte et un rendez-vous avait ete pris lors de cette rencontre, pour proposer un concert commun en cette annee 2013. Les deux groupes se sont donc retrouves a Charroux, village classe parmi les plus beaux villages de France, situe pres de Gannat. La petite eglise (...)
Letters to the Editor (2009)

Journal Article Letters to the Editor Get access Harold N. Graham, Harold N. Graham Vice President Research and Product Development Thomas J. Lipton, Inc. 800 Sylvan Ave. Englewood Cliffs, NJ 07632 Search for other works by this author on: Oxford Academic PubMed Google Scholar D.M. Graham D.M. Graham Scientific Research Del Monte Corporation 205 North Wiget Lane Walnut Creek, CA 94598 Search for other works by this author on: Oxford Academic PubMed Google Scholar Nutrition Reviews, Volume 36, Issue 9, September 1978, Pages 294–295, https://doi.org/10.1111/j.1753-4887.1978.tb07402.x Published: 01 September 1978
Species specificity of cholecystokinin in gut and brain of several mammalian species. (1978)

Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the monkey, dog, and pig, by using an antiserum with equivalent sensitivities for detecting the octapeptide in free form or incorporated in the intact molecule. The failure to detect intact cholecystokinin in extracts from monkey or dog by using an antiserum developed by immunization with porcine cholecystokinin is presumed to be due to marked species differences in the NH2-terminal portion of the molecule. Tryptic digestion converted the intact cholecystokinin from all species to a peptide resembling the COOH-terminal octapeptide. The amount of cholecystokinin in the brain is comparable to that found in the gastrointestinal tract, the traditional site for this peptide.
Iron-Catalysed Reformatsky-Type Reactions (2006)

A Reformatsky-type reaction has been developed using iron catalysis in acetonitrile or DMF. Reduction of iron(II) bromide by manganese metal in acetonitrile provides a low-valent iron catalyst, which is the active species; under these conditions, α-chloroesters or nitriles can both be converted into their corresponding derivatives. The method was applicable to both ketones and aldehydes, resulting in the formation of β-hydroxyesters under mild conditions.
Targeting VEGF signalling via the neuropilin co-receptor (2012)

The blockade of tumour vascularisation and angiogenesis continues to be a focus for drug development in oncology and other pathologies. Historically, targeting vascular endothelial growth factor (VEGF) activity and its association with VEGF receptors (VEGFRs) has represented the most promising line of attack. More recently, the recognition that VEGFR co-receptors, neuropilin-1 and -2 (NRP1 and NRP2), are also engaged by specific VEGF isoforms in tandem with the VEGFRs has expanded the landscape for the development of modulators of VEGF-dependent signalling. Here, we review the recent structural characterisation of VEGF interactions with NRP subdomains and the impact this has had on drug development activity in this area.
Monolithic integration of InGaAs/InAlGaAs-based semiconductor optical amplifiers and 10 Gb/s broadband electro-absorption modulators using quantum well intermixing technology (2005)

Mach-Zehnder phase modulators fabricated in LiNbO/sub 3/ (LN) dominate the market for data modulators at 10 Gb/s. Although LN modulators display a high-power handling capability with controlled chirp over a large optical bandwidth (i.e., full C-band), they are relatively large and expensive to manufacture when compared to semiconductor devices. By contrast, InP-based electro-absorption modulators (EAMs) are much more compact; however they have a limited bandwidth (5-10 nm) over which chirp is in the correct range to allow > 80 km reach. This paper presents the broadband electro-absorption modulator (BEAM) chip concept, which consists of monolithically integrating a series of EAMs using quantum well intermixing with each one tuned to give the correct chirp over a certain wavelength range. The total bandwidth of the device is thus extended to cover the whole C-band. In addition, a semiconductor optical amplifier (SOA) is serially integrated with the EAMs to recover the insertion loss due to fiber coupling and the series of EAMs. A unique quantum well intermixing (QWI) process is the method employed to achieve the monolithic integration of the multiple sections required for the BEAM chip. Key results reported here are open 10 Gb/s eye diagrams of the integrated EAMs along with data from the demo BEAM chips showing the achievement of >10 dB extinction ratio across the C-band, with >35 km reach.
Comparison of Hepatocellular Carcinoma Patients With Alcoholic Liver Disease and Nonalcoholic Steatohepatitis (2004)

Severe fibrosis might be an important risk factor for HCC. Patients who have ALD or NASH with cirrhosis may develop HCC. This seems to occur in a sufficient number of cases to warrant regular screening for this complication.
Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction: Insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT) (2015)

In VALIANT, the risk of HF following MI was higher in women than men after adjusting for age and comorbidities, although the risk of other fatal and non-fatal outcomes were similar. The higher long-term risk of HF in women appears to be independent of the extent of left ventricular systolic dysfunction or remodelling compared with men.
Investigations on human lutropin from pituitary gland and urine. (1997)

Two newly isolated monoclonal anti-beta hLH antibodies did not recognize both human chorionic gonadotropin (hCG) and three synthetic peptide fragments corresponding to beta hLH sequence. These antibodies were applied for ELISA of human luteinizing hormone (hLH), however, sensitivities of these assays were much lower than those with two other monoclonal antibodies obtained earlier in our laboratory. No significant differences between assays of hLH from pituitary and urine with 6 different pairs of monoclonal antibodies (4 anti-beta and 1 anti-alpha-subunit) were noticed. The highest hLH concentration in urine samples collected during 53 menstrual cycles of 6 women was demonstrated at different times of the day. In 14 out of 52 "preovulatory urine" portions, preserved for several weeks, over 80% increase of assayed hLH was shown. The highest assays of hLH from pituitary and urine were noted at pH 7.5-9.0. Using affinity chromatography the whole pituitary hLH was bound to ConA-Sepharose column and was eluted with alpha-methyl-D-mannoside as a single peak. However, a small part of hLH from urine was eluted from the column as non retarded peak. When HPLC analysis with DEAE column was performed, pituitary hLH was separated in two fractions while lutropin from urine was eluted as a single peak.
SciA11y: Converting Scientific Papers to Accessible HTML (2021)

We present SciA11y, a system that renders inaccessible scientific paper PDFs into HTML. SciA11y uses machine learning models to extract and understand the content of scientific PDFs, and reorganizes the resulting paper components into a form that better supports skimming and scanning for blind and low vision (BLV) readers. SciA11y adds navigation features such as tagged headings, a table of contents, and bidirectional links between inline citations and references, which allow readers to resolve citations without losing their context. A set of 1.5 million open access papers are processed and available at https://scia11y.org/. This system is a first step in addressing scientific PDF accessibility, and may significantly improve the experience of paper reading for BLV users.
A Novel Genioglossal Strengthening Device for Obstructive Sleep Apnea Treatment (2018)

Obstructive sleep apnea (OSA) is a condition characterized by temporary diminutions or cessations of breathing caused by repetitive collapse of the upper airway (UA) during sleep [1]. OSA is a common disorder — the American Academy of Sleep Medicine estimates the condition affects 29.4 million Americans — in which the muscles that hold the airway open weaken, resulting in partial or complete UA collapse during inspiration [2]. These pauses in breathing lead to blood oxygen desaturation and induce neurological arousal resulting in sleep disruption and fragmentation. The cycle of airway collapse and arousal can repeat hundreds of times per night.
Collisional angular-momentum mixing of highly excited<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi mathvariant="normal">Na</mml:mi><mml:mo>(</mml:mo><mml:mi>n</mml:mi><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi>D</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow><mml:mo>)</mml:mo></mml:math>states by<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">N</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>and CO (1977)

Cross sections for the collisional $l$ mixing of $\mathrm{Na}(n^{2}D)$ states from $n=5 \mathrm{to} 14$ by ${\mathrm{N}}_{2}$ and CO have been measured by time-resolved laser fluorescence and calculated in a two-state approximation by assuming the perturbing gases are spherically symmetric. For both CO and ${\mathrm{N}}_{2}$ the experimental cross sections rise sharply from $n=5$ to $n=10$ and remain constant for $n>10$. The theoretical calculations overestimate the experimental cross sections by a factor of 3 from $n=10 \mathrm{to} 12$, but are in good agreement for the smaller $n$ values.
Frequency and analysis of factors closely associated with the development of depressive symptoms in patients with scleroderma. (2003)

Our results indicate that depressive symptoms are frequent in SSc patients. Medical staffs should pay attention to the possible risk factors for depressive symptoms, such as patient's helplessness and SOC.
The Origin of Certain Granitic Rocks Occurring In Glamorgan Township, Southeastern Ontario (1967)

<p> Glamorgan township in southeastern Ontario, is underlain by Precambrian rocks of the Grenville province. Prominent amongst these are migmatite, paragneiss, and granite gneiss, VJhich collectively form a series of rocks (the Glamorgan gneiss aeries). </p>\n<p> Field work revealed that this series is completely gradational from a geological aspect, and that the geological gradation is complemented by a geochemical gradation. \n<p> An explanation of these gradational relationships constitutes the main contribution of this study. The conclusions reached are that partial melting of paragneiss produced migmatite and a trondhjemitic melt, which later produced granitic (in the strict sense) derivatives. </p>\n<p> In developing the main conclusions, a number of subsidiary problems are discussed, chief of which are the possible metavolcanic or metasedimentary o'rigin of the paragneiss and the possible origin of so-called diorite as a differentiate of an alkaline gabbro. Metamorphism was concluded to be of Miyashiro's low pressure intermediate type. </p>\n<p> By the use of experimentally determined reactions and stability fields a metamorphic grid was devised, which led to the following upper limits of metamorphic conditions: 550 to 650°C and 3 to 6.5 kilobars total pre5sure. These estimates in turn lead to the following limiting geothermal gradients: 25 to 55°C per kilometre. </p>\n<p> The Glamorgan occurrence was found to share three characteristics with many other Precambrian terrains : 1. migmatisation and emplacement of granite accompanied high grade metamorphism; 2. an early sodium-rich granite was followed by a more potassic one; and 3. the more sodic granite is associated with a small amount of basic igneous rock. These three generalisations were used to formulate a possible model for deep crustal petrogenesis. </p>
Oral Administration of Cyclopentane Neuraminidase Inhibitors Protects Ferrets against Influenza Virus Infection (2002)

Several cyclopentane inhibitors of influenza virus neuraminidase that have inhibitory activities in tissue culture similar to those of zanamivir and oseltamivir have recently been described. These new inhibitors have been examined for efficacy against a virulent H3N2 influenza virus when administered orally to infected ferrets. Preliminary studies indicated that oral administration of BCX-1923, BCX-1827, or BCX-1812 (RWJ-270201) at a dose of 5 or 25 mg/kg of body weight was active in ferrets in reducing respiratory and constitutional signs and symptoms, but these antivirals affected virus titers in the upper and lower respiratory tracts only marginally. Of the three compounds, BCX-1812 seemed to be the most efficacious and was examined further at higher doses of 30 and 100 mg/kg. These doses significantly reduced peak virus titers in nasal washes and total virus shedding as measured by areas under the curve. Virus titers in lung homogenates were also reduced compared to those in controls, but the difference was not statistically significant. As was observed with BCX-1812 at lower doses, the nasal inflammatory cellular response, fever, and nasal signs were reduced while ferret activity was not, with activity remaining similar to uninfected animals.
Comments on "Simulation of large magnetic islands: A possible mechanism for a major tokamak disruption" (1978)

In this Comment it is established that the numerical results for the nonlinear evolution of the $m=2$ tearing mode are affected by the density of the poloidal grid. A coarse grid gives results that are quantitatively and qualitatively incorrect. The important qualitative error is that with a coarse grid the growth of the width of the associated magnetic island is exponential rather than algebraic.
Probing Solvation-Shell Hydrogen Binding in Glassy and Sol−Gel Matrixes through Vibronic Sideband Luminescence Spectroscopy (2003)

The luminescence spectrum from Gd(III) contains vibronic sidebands that provide the vibrational frequencies of molecules that comprise the solvation shell surrounding this cation. The vibronic sidebands obtained from Gd(III) in porous sol−gel matrixes as a function of added glycerol and in trehalose-derived glassy matrixes are used to probe matrix- and solvent-induced changes in the hydrogen bonding between first- and second-shell solvent molecules. The results provide direct insight into the origin of the damped dynamics observed for guest proteins within these types of matrixes. The results are also consistent with the retention of water within the first solvation shell for both the glassy matrixes and the glycerol-bathed sol−gel.
Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation (2003)

We reported an association between the ability of recombinant human keratinocyte growth factor (rHuKGF) to upregulate the expression of surfactant protein A (SP-A) and to downregulate pulmonary inflammation that occurs after allogeneic bone marrow transplantation (BMT). To establish a causal relationship, rHuKGF (5 mg/kg) was administered subcutaneously for three consecutive days before irradiation to SP-A-sufficient and -deficient [SP-A(+/+) and SP-A(-/-), respectively] mice given inflammation-inducing allogeneic spleen T cells at the time of BMT. In contrast with SP-A(+/+) mice, rHuKGF failed to suppress the high levels of TNF-alpha, IFN-gamma, and nitric oxide contained in bronchoalveolar lavage fluids collected on day 7 after BMT from SP-A(-/-) mice. Early post-BMT weight loss was attenuated by rHuKGF in both SP-A(+/+) and SP-A(-/-) recipients. In the absence of supportive respiratory care, however, SP-A deficiency eventually abolished the ability of rHuKGF to prevent weight loss and to improve survival monitored for 1 mo after allogeneic BMT. In further experiments, the addition of cyclophosphamide (which is known to cause severe injury to the alveolar epithelium in donor T cell-recipient mice) to the conditioning regimen prevented rHuKGF-induced upregulation of SP-A and suppression of lung inflammation in both SP-A(+/+) and SP-A(-/-) mice. We conclude that endogenous baseline SP-A levels and optimal upregulation of SP-A are required for the anti-inflammatory protective effects of KGF after allogeneic transplantation.
Pyridazines. L. Methylations and methyl group migrations of some imidazo[1,2-b]pyridazines (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyridazines. L. Methylations and methyl group migrations of some imidazo[1,2-b]pyridazinesM. Furlan, B. Stanovnik, and M. TislerCite this: J. Org. Chem. 1972, 37, 17, 2689–2691Publication Date (Print):August 1, 1972Publication History Published online1 May 2002Published inissue 1 August 1972https://pubs.acs.org/doi/10.1021/jo00982a013https://doi.org/10.1021/jo00982a013research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts