gebhart/patrepeval huggingface dataset:
Heart rate fragmentation: using cardiac pacemaker dynamics to probe the pace of biological aging (2019)

This perspectives article discusses the use of a novel set of dynamical biomarkers in the assessment of biological versus chronological age. The basis for this development is a recently delineated property of altered sinoatrial pacemaker-neuroautonomic function, termed heart rate fragmentation (HRF). Fragmented rhythms manifest as an increase in the density of changes in heart rate acceleration sign, not mechanistically explicable by physiological cardiac vagal tone modulation. We reported that HRF increased monotonically with cross-sectional age and that HRF measures, but not conventional heart rate variability metrics, were significantly associated with major incident cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA). Furthermore, HRF measures added value to both Framingham and MESA cardiovascular risk indices. Here, we propose that interventions that fundamentally slow or reverse the pace of biological aging, via system-wide effects, should be associated with a decrease in the degree of HRF and possibly with a reemergence of the nonfragmented ("fluent") patterns associated with more youthful heart rate dynamics.
NASA Glenn's Seals Group Inaugurated a New State-of-the-Art High-Temperature Test Rig (2004)

The NASA Glenn Research Center is developing advanced control surface seals and propulsion system seals for future space and launch vehicles. To evaluate new seal designs, the Glenn Seals Team recently inaugurated a new state-of-the-art high temperature seal test facility. The Hot Compression/Hot Scrub Rig can perform either high-temperature seal-compression tests or scrub tests at temperatures of up to 3000 F by using different combinations of test fixtures made of monolithic silicon carbide (Hexoloy alpha-SiC), as shown in the following figures. For lower temperature tests (up to 1500 F), Inconel X-750 test fixturing can be used.
5-Nitro-2-pyridyl-1-thioglucosides: application in synthesis of analogues of glycosyltransferases natural substrates. (2011)

5-Nitro-2-pyridyl-1-thioglucosides were used in synthesis of complex uridine derivatives (13-16) in two different sequences of reactions. In one route, the first step was glycosylation of selectively protected 5-nitro-2-pyridyl-1-thioglucoside 1 with two different glycosyl donors (5 or 6), next, the nitro group in aglycone of obtained disaccharides 7 or 8 was reduced and then obtained products 9 or 10 were condensed with uridine derivatives 3 or 4 using DMT-MM as condensing agent under microwave irradiation. In the second route, condensation and glycosylation reactions were applied in reverse order. As it turned up, a sequence of reactions affected the yield of final glycoconjugates 13-16 and depended on the type of uridine derivatives used.
Structure and Function of the Growth Plate (1978)

BRIGHTON, CARL T. M.D., PH.D.Editor(s): AMSTUTZ, HARLAN C. M.D.; SAKAI, DENNIS N. M.D. Author Information
Functional and growth properties of a myometrial cell line derived from transgenic mice: effects of estradiol and antiestrogens. (1996)

This study describes the properties of a myometrial cell line, m-M116, that was derived from a leiomyoma developed in an adult female transgenic mouse harboring the simian virus 40 large T antigen (Tag) under the control of the 5'-regulatory sequence of the calbindin D9k (CaBP9k) gene. As the expression of this transgene is governed by the CaBP9k estrogen-responsive element, m-M116 cells were grown in medium supplemented with 17 beta-estradiol. The cells were long lived, had Tag-positive nuclei, and were nontumorigenic when injected into nude mice. They formed irregular layers of elongated cells with typical features of uterine, smooth muscle cells, as assessed by the presence of alpha-smooth muscle actin and desmin filaments, estradiol and progesterone receptors, and expression of the CaBP9k gene. The rate of cell doublings and the expression of the Tag gene in early passaged cells depended on the presence of 17 beta-estradiol. Tamoxifen, a mixed estrogen agonist-antagonist, also stimulated the growth of m-M116 cells, whereas ICI 182 780, a pure antiestrogen, blocked cell growth. Later passages of m-M116 cells still had a smooth muscle phenotype, but proliferated even in the absence of 17 beta-estradiol. These mouse uterine smooth muscle cells obtained by targeted oncogenesis provide a useful model for studies of the progression of steroid-independent carcinomas.
Properties of Blue and Green InGaN/GaN Quantum Well Emission on Structured Semipolar Surfaces (2009)

We investigate the properties of semipolar InGaN/GaN quantum wells (QWs) emitting in the blue and green spectral region. A single QW is grown on inverse V-shaped GaN pyramids which are formed by selective area epitaxy on a template masked with different hexagonally ordered patterns. Using photo- and locally resolved cathodoluminescence measurements the high material quality of the semipolar planes could be confirmed (full width at half maximum (FWHM) of D0X: 2.6 meV). Furthermore, it was found that the InGaN QW emission wavelength within one pyramid depends on the facet type as well as on the position along the facet.
DRY MATIER LEVEL EFFECTS ON ALFALFA SILAGE QUALITY II.FERMENTATION PRODUCTS AND STARCH HYDROLYSIS (1990)

ABSTRACT Alfalfa was ensiled at different dry matter (DM) levels. Increasing DM content reduced the rate and total amount of fermentation and resulted in a higher pH. The ratio of fermentation end products varied with both DM content and time. The highest relative levels of lactic acid were in silages of 40 to 55% DM. Acetic and succinic acids were highest in unwilted silages, and relative production of ethanol was greatest in > 60% DM silages. These results suggest variations in the dominant lactic acid bacterial strains as a function of DM content. High amounts of startch hydrolysis observed in unwilted alfalfa were the result of high starch contents in the crop at the ensiling. Glucose addition reduced final pH only in silages of less than 50% DM where substrate level limited fermentation.
Resistance to Infection by Subgroups B, D, and E Avian Sarcoma and Leukosis Viruses Is Explained by a Premature Stop Codon within a Resistance Allele of the <i>tvb</i> Receptor Gene (2002)

Here we present the first molecular characterization of the defect associated with an avian sarcoma and leukosis virus (ASLV) receptor resistance allele, tvb(r). We show that resistance to infection by subgroups B, D, and E ASLV is explained by the presence of a single base pair mutation that distinguishes this allele from tvb(s1), an allele which encodes a receptor for all three viral subgroups. This mutation generates an in-frame stop codon that is predicted to lead to the production of a severely truncated protein.
A Camera Tube with a Silicon Diode Array Target (1967)

A variety of electronic cameras have been developed for television systems. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> Among these the vidicon <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and the Plumbicon <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> have the inherent advantages of high sensitivity, small size, and simple mechanical construction. The operating principles of the vidicon and the Plumbicon are quite similar since they both utilize a thin photoconductive layer to convert the optical image to a stored charge pattern which is periodically scanned and erased by an electron beam. Erasing the charge pattern creates the video signal. However, there is a distinct difference in overall device performance since the photoconducting target in the Plumbicon (PbO) is deposited in a manner to form a single, large area, graded p-n junction, each layer having high resistivity. In the vidicon, the evaporated layers of Sb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> S <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> forming the target behave like a semi-insulating photoconductor.
Celiac Disease (1962)

DICKE1 first described over a decade ago the dramatic improvement that occurs in childhood celiac disease after elimination of dietary wheat and rye. It was later shown that the offending agent in wheat is confined to the protein moiety, gluten, and more specifically to its gliadin fraction.2 Oats are believed to contain a similar offending protein.2 Many observers, beginning with McIver,3 have confirmed the effectiveness of a gluten-free diet in the treatment of adults with celiac disease ("nontropical sprue" or "idiopathic sprue") as well as patients with childhood celiac disease. Furthermore, peroral biopsy4 , 5 has made possible repeated demonstration of a . . .
Insect Moulting Activity of Crude Drugs and Plants. (1). (1967)

Ethanolic extracts of crude drugs and plants were examined for a possible metamorphosis activity in insects, by observing the state of pupation, using the free abdomen of flies. The results are summarized in Tables I to V. Among the crude drugs, bezoar as well as the leaves of taxum and mulberry showed such activity. Among the plants, no marked activity was found in mushrooms and sea-weeds. Among the ferns some activity was found in Blechnum nipponicum, Athyrium nipponicum, A. squamigerum, Lastrea japonica, Rumohra miqueliana, and Dryopteris chinensis. In higher plants, Podocarpus nakaii and Achyranthes spp. showed the activity, and so did also Taxus cuspidata var. nana, Podocarpus nagi, Torreya nucifera, Akebia quinata, Amaranthus spinosus, A. magnostanus, and A. viridis.
Use of cDNA microarray to isolate differentially expressed genes in White Spot Virus infected shrimp (penaeus stylirostris) (2006)

White spot syndrome virus (WSSV), the etiologic agent of white spot disease, is currently the most important viral pathogen infecting penaeid shrimp worldwide. Since the initial report, white spot disease has caused losses of catastrophic proportion to shrimp aquaculture globally. Although considerable progress has been made in characterizing the WSSV and developing detection methods, information on the host genes involved in the immune response in shrimp due to WSSV infection is not available. During this research, the mRNA expression profiles in healthy and WSSV-infected shrimp were determined by analyzing the expressed sequence tags (ESTs) and by microarray analysis. Our data show that WSSV infection alters the expression of a wide array of genes including those that are involved in immune function, signal transduction, structural genes, as well as mitochondrial genes among others. Using EST analysis and real-time RT-PCR, we also identified a candidate receptor gene for another viral pathogen of shrimp, the Taura syndrome virus (TSV). These data show that the potential for using the mRNA expression level of candidate genes as biomarkers for identifying virus-resistant or virus-susceptible lines in shrimp.
Development of high power X-band TWTs (1993)

Summary form only given. A program to develop high-power X-band traveling wave tube amplifiers using relativistic electron beams (0.8-1.0 MV, 0.8-1.8 kA, 70-100 ns) is in progress. At output power levels in excess of 70 MW the development of asymmetric sidebands has been observed. Extensive analytical work suggests that this phenomenon is caused by the large energy spread that develops in the electron distribution during the interaction process. This energy spread excites a broad spectrum of noise as the modulated electron beam enters the second stage of the amplifier. Reflections from the ends of these structures cause only selected frequencies to be transmitted through the device, leading to the observed sidebands. To reduce the effect of reflections, and thus the development of sidebands, narrow passband structures with passband /spl sim/200 MHz are being used. These structures typically have group velocity /spl sim/0.01c. This value ensures that the feedback time from any reflections is comparable to the beam pulse duration. Measurements using these structures show gains over a narrow bandwidth with no evidence of sidebands.
Medical and Biochemical Application of Infrared Absorption Spectra. IV. Studies on Gall Stones by Infrared Spectra and their New Classification (1960)

Infrared absorption spectra of over 500 pieces of gall stone were measured and analysis of gall stones by infrared spectra was established. This is the best method now known for the analyses of gall stones. Spectra were newly obtained for a group of calculi containing stearic acid, calcium stearate, triglyceride, and polysaccharide. Almost all of the gall stones are composed of a combination of such substances and cholesterol, calcium salt of bilirubin, calcium carbonate, calcium phosphate, and proteins, in various ratios and in variety of modes. A new classification has been proposed based on these chief components. It was also found that there is a vast difference in gall-stone components between urban and rural areas. Cholesterol, which is found in metropolitan area, is rare in rural villages and in its stead ratio of calcium stearate to calcium salt of bilirubin increases.
Primary non-Hodgkin’s lymphoma of the breast: First report of the multicentre retrospective study of the International Extranodal Lymphoma Study Group (IELSG-15) (2005)

6575 Background: Primary breast lymphoma is a rare poorly-defined condition. This large multi-centre retrospective review investigates its prognosis and patterns of relapse. Methods: Patients presenting with histologically-proven primary non-Hodgkin’s lymphoma of one or both breasts between 1980 and 2003 are included. Data was obtained retrospectively from patient medical records. Central histology review was undertaken where possible. Survival curves were estimated using the Kaplan-Meier method, and prognostic factors analysed by univariate and multivariate analysis. The major study endpoints were progression-free and overall survival. Results: A total of 276 eligible patients were identified. Of these, 202 patients had diffuse large B-cell histology, and form the basis of this analysis. Sixty-seven percent of patients had Stage IE disease, 28% were stage IIE, and 5% were stage IVE(bilateral). B-symptoms were present in 4%. International Prognostic Index (IPI) was 0,1,2 and 3 in 27,37,15 and 3%, respectively. Eighty percent of patients received chemotherapy, 64% radiotherapy, and 50% both, with 87% of patients achieving a complete response at the end of planned first-line therapy. Thirty-seven percent of patients subsequently progressed in one or more sites. The crude rates for recurrence in breast, loco-regional nodes, and central nervous system (CNS) were 15%, 6%, and 5%. Only one breast relapse occurred in an irradiated breast. The median progression-free survival was 5.9 years (95% CI: 3.7, 8.0), with a median follow-up duration of 5.5 years. Median overall survival was 8.4 years (95% CI: 6.5, 10.9). The only statistically significant prognostic factor on multifactor analysis was IPI. Conclusions: The outcome for patients presenting with primary diffuse large B-cell non-Hodgkin’s lymphoma of the breast was significantly worse than that anticipated for Stage I and II nodal lymphomas treated during a similar period. The data suggests that future prospective studies should investigate intensification of treatment, and that the addition of specific prophylactic therapy targeted at the major sites of recurrence may improve prognosis. No significant financial relationships to disclose.
Enumeration of Lactotropes and Somatotropes among Male and Female Pituitary Cells in Culture: Evidence in Favor of a Mammosomatotrope Subpopulation in the Rat* (1985)

The hemolytic plaque assay technique can be used to detect specific hormone release from single pituitary cells. Using antisera raised against murine GH or rat PRL, we have enumerated the active lactotropes and somatotropes from male and female rat pituitary glands. These studies reveal sex-related differences in the number of cells exporting GH and PRL among anterior pituitary cells in culture. In the presence of human GH-releasing factor (hGRF), the mean percentage of GH cells was 53% in males and 30% in females (P less than 0.005). The mean percentage of PRL cells was 15% in males and 39% in females (P less than 0.008). These values were not significantly altered when hGRF was omitted. The sum of GH and PRL cells identified in separate plaque assays significantly exceeds the number obtained when GH and PRL cells were determined concurrently with a simultaneous plaque assay for both hormones. This difference is dependent on the presence of hGRF, since there was no difference when hGRF was omitted. These data identify the mammosomatotrope in numbers lower than previous reports. By this approach, the mammosomatotrope subpopulation numbers about 5% of all cells in culture. In summary, we demonstrate a sex-related difference in the number of cells exporting GH or PRL among pituitary cells in culture. This difference corresponds with and may underly sex-related differences in the responsiveness of GH and PRL secretion from the pituitary gland. Furthermore, a minor subpopulation of normal pituitary cells appears capable of simultaneous secretion of both GH and PRL.
A new systolic array algorithm for discrete Fourier transform (1991)

A new systolic algorithm for computing the discrete Fourier transform (DFT) is presented. The algorithm exhibits the minimum required time O(Nt/sub a/) and the computational complexity O(2N/sup 2/), which are much better than the time O(Nt/sub a/+Nt/sub m/) and the complexity O(4N/sup 2/) in existing systolic algorithms, where t/sub a/ and t/sub m/ are the computation time for a complex addition and a complex multiplication, respectively, and N is the DFT length. By exerting the benefits of the algorithm and adopting the scheme of tag control, a systolic array and a two-level pipelined systolic array are designed. The resulting arrays have outstanding performance on computing speeds, hardware cost, and the number of input/output (I/O) channels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Safety and feasibility of virus-specific T cells derived from umbilical cord blood in cord blood transplant recipients (2019)

Adoptive transfer of virus-specific T cells (VSTs) has been shown to be safe and effective in stem cell transplant recipients. However, the lack of virus-experienced T cells in donor cord blood (CB) has prevented the development of ex vivo expanded donor-derived VSTs for recipients of this stem cell source. Here we evaluated the feasibility and safety of ex vivo expansion of CB T cells from the 20% fraction of the CB unit in pediatric patients receiving a single CB transplant (CBT). In 2 clinical trials conducted at 2 separate sites, we manufactured CB-derived multivirus-specific T cells (CB-VSTs) targeting Epstein-Barr virus (EBV), adenovirus, and cytomegalovirus (CMV) for 18 (86%) of 21 patients demonstrating feasibility. Manufacturing for 2 CB-VSTs failed to meet lot release because of insufficient cell recovery, and there was 1 sterility breach during separation of the frozen 20% fraction. Delayed engraftment was not observed in patients who received the remaining 80% fraction for the primary CBT. There was no grade 3 to 4 acute graft-versus-host disease (GVHD) associated with the infusion of CB-VSTs. None of the 7 patients who received CB-VSTs as prophylaxis developed end-organ disease from CMV, EBV, or adenovirus. In 7 patients receiving CB-VSTs for viral reactivation or infection, only 1 patient developed end-organ viral disease, which was in an immune privileged site (CMV retinitis) and occurred after steroid therapy for GVHD. Finally, we demonstrated the long-term persistence of adoptively transferred CB-VSTs using T-cell receptor-Vβ clonotype tracking, suggesting that CB-VSTs are a feasible addition to antiviral pharmacotherapy.
Adult-Onset Autoimmune Diabetes in Europe Is Prevalent With a Broad Clinical Phenotype (2012)

OBJECTIVE Specific autoantibodies characterize type 1 diabetes in childhood but are also found in adult-onset diabetes, even when initially non–insulin requiring, e.g., with latent autoimmune diabetes (LADA). We aimed to characterize adult-onset autoimmune diabetes. RESEARCH DESIGN AND METHODS We consecutively studied 6,156 European diabetic patients attending clinics within 5 years of diagnosis (age range, 30–70 years) examined cross-sectionally clinically and for GAD antibodies (GADA) and antibodies to insulinoma-associated antigen-2 (IA-2A) and zinc-transporter 8 (ZnT8A). RESULTS Of 6,156 patients, 541 (8.8%) had GADA and only 57 (0.9%) IA-2A or ZnT8A alone. More autoantibody-positive than autoantibody-negative patients were younger, leaner, on insulin (49.5 vs. 13.2%), and female (P &lt; 0.0001 for each), though LADA patients (9.7% of total) did not show categorically distinct clinical features from autoantibody-negative type 2 diabetes. Similarly, more GADA patients with high (&gt;200 World Health Organization IU) (n = 403) compared with low (n = 138) titer were female, lean, and insulin treated (54.6 vs. 39.7%) (P &lt; 0.02 for each). Autoantibody-positive patients usually had GADA (541 of 598; 90.5%) and had LADA more often than type 1 autoimmune diabetes (odds ratio 3.3). CONCLUSIONS Adult-onset autoimmune diabetes emerges as a prevalent form of autoimmune diabetes. Our results indicate that adult-onset autoimmune diabetes in Europe encompasses type 1 diabetes and LADA in the same broad clinical and autoantibody-positive spectrum. At diagnosis, patients with adult-onset autoimmune diabetes are usually non–insulin requiring and clinically indistinguishable from patients with type 2 diabetes, though they tend to be younger and leaner. Only with screening for autoantibodies, especially GADA, can they be identified with certainty.
Petroclival Meningiomas: A Clinicopathological Correlation (2008)

Aim: Petroclival tumors are rare and require extensive skull base approaches, and are associated with high morbidity/mortality due to their location/relationship to adjacent neurovascular structures.
Lignin. XI. Estimation of Polymolecularity in Lignin Sulfonate Polymers from Diffusion Measurements (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLignin. XI. Estimation of Polymolecularity in Lignin Sulfonate Polymers from Diffusion MeasurementsJ. Moacanin, H. Nelson, E. Back, V. F. Felicetta, and Joseph L. McCarthyCite this: J. Am. Chem. Soc. 1959, 81, 9, 2054–2060Publication Date (Print):May 1, 1959Publication History Published online1 May 2002Published inissue 1 May 1959https://pubs.acs.org/doi/10.1021/ja01518a006https://doi.org/10.1021/ja01518a006research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts