gebhart/patrepeval huggingface dataset:
Uptake of Radioactive Sulphur in the Endolymphatic Sac:<i>An Autoradiographic Study</i> (1989)

Autoradiographic uptake of labelled sulphur (S35) in the endolymphatic sac was analysed after performing surgical labyrinthectomy and after systemic administration of glycerol and ethacrynic acid. Accumulation of radioactive substance was observed after surgical labyrinthectomy and associated with a deposition of stainable substance in the endolymphatic sac lumen. Increased activity was noted in the epithelial layer after administration of ethacrynic acid, whereas glycerol did not increase radioactivity in the endolymphatic sac despite the deposition of stainable substance therein. This fact was believed to depend on a too short time interval between the injection and the sacrifice of the animals, as well as a weaker concentration of the sulphated compound within the endolymphatic sac. The results suggest that the endolymphatic sac may secrete sulphur-containing substances presumably associated with a deposition of a stainable substance in the endolymphatic sac.
The E‐box DNA binding protein Sgc1p suppresses the <i>gcr2</i> mutation, which is involved in transcriptional activation of glycolytic genes in <i>Saccharomyces cerevisiae</i> (1999)

Glycolytic gene expression is mediated by the Gcr1p-Gcr2p transcriptional activation complex. A screen for multicopy suppressors of gcr2 yielded SGC1. SGC1's suppression activity was specific to gcr2, it did not extend to gcr1. Disruption of SGC1 moderately affected glycolytic enzyme activities, although no growth defect was evident. Sgc1p exhibits a bHLH motif which is characteristic of E-box DNA-binding proteins. DNA footprinting experiments demonstrated Sgc1p's ability to bind at an E-box. However, its binding specificity was less than 10-fold, which is also characteristic of E-box binding proteins. LexA fusion experiments demonstrated that Sgc1p has weak intrinsic activating activity independent of GCR1 and GCR2. We propose that Sgc1p binds at E-boxes of glycolytic genes and contributes to their activation.
RELIBase – an object-oriented comprehensive receptor–ligand database (1996)

Note: ABSTR PAP AM CHEM S 211: 49-CINF Part 1 Reference LSIR-CONF-2000-020 Record created on 2005-09-15, modified on 2017-05-12
Biologically Active Constituents of Magnolia salicifolia: Inhibitiors of Induced Histamine Release from Rat Mast Cells. (1991)

The extracts of the flower buds of Magnolia salicifolia showed remarkable anti-allergy effects in passive cutaneous anaphylaxis (PCA) test. The bioactive constituents of this medicinal drug were isolated by monitoring their activities with an in vitro bioassay system measuring inhibitory effects on induced histamine release from rat mast cells. Of the ten isolated compounds magnosalicin is a new compound of neolignan structure. In addition to the isolated compounds samples of coumarins and lignans were evaluated their biological activities with the in vitro bioassay.
A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department (2011)

Background Rapid-onset antidepressants could have important clinical impact if their benefits extended to ED patients. We examined preliminary feasibility, tolerability and efficacy of single-dose IV ketamine in depressed ED patients with suicide ideation (SI). Methods Fourteen depressed ED patients with SI received a single IV bolus of ketamine (0.2 mg/kg) over 1–2 minutes. Patients were monitored for 4 hours, then re-contacted daily for 10 days. Treatment response and time to remission were evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS) and Kaplan Meier survival analysis, respectively. Results Brief Psychiatric Rating Scale and Young Mania Rating Scale scores transiently increased in two subjects, consistent with ketamine's cognitive/behavioral effects in other populations. Mean MADRS scores fell significantly from 40.4 (SEM:1.8) at baseline to 11.5 (2.2) at 240 minutes. Median time to MADRS score ≤10 was 80 minutes (Interquartile Range: 0.67–24 hours). Suicide ideation scores (MADRS item 10) decreased significantly from 3.9 (SEM:0.4) at baseline to 0.6 (SEM:0.2) at 40 minutes post-administration, with improvements sustained over 10 days. Conclusions These data provide preliminary, open-label support for the feasibility and efficacy of ketamine as a rapid-onset antidepressant in the ED.
Laryngopharyngeal Reflux Identified Using a New Catheter Design: Defining Normal Values and Excluding Artifacts (2003)

The triple-electrode bifurcated adjustable pH probe provides a well-tolerated technique to identify true hypopharyngeal acid reflux episodes. When artifacts produced by meals and pseudoreflux are excluded, 90% of normal subjects show no episodes or a single episode over a 24-hour period.
Development of a Seawater Hydraulic Rock Drill (1991)

Under the Underwater Construction System program, a seawater hydraulic tool system called the Multi-Function Tool System (MFTS) was developed. An objective of the MFTS development was to provide Underwater Construction Team divers with tools that meet their operational needs and were optimized for both the diver and the environment. A seawater hydraulic rock drill has not been issued because its performance is not predictable and its operation is not reliable. Extensive testing has isolated the problem to the impact mechanism and the timing of the cycle. Leakage of the supply poppet and the drive plunger as well as pressure pulsations from the rapid closing of the supply poppet have an undetermined negative affect on cycle operation. Cycle performance is not repeatable from test to test suggesting a transient or threshold condition that the drill is not always able to overcome. Additional development of the water lubricated impact mechanism is needed to investigate and correct these problems. While sea water is an attractive alternative to oil, it promotes sea water corrosion in metals, and the low viscosity of seawater offers minimal lubrication and high leakage rates compared to oils. These factors complicate the design of limiting material selection to those satisfying corrosion and lubrication criteria. In addition, close tolerance machining is necessary.
All-fiber optic ultrasonic structural health monitoring system (2009)

Structural Health Monitoring (SHM) is required for early detection of damage in structural components to improve the safety, reduce the cost, and increase the performance and efficiency of aircrafts. Currently available techniques have a number of deficiencies prohibiting wide spread of SHM in aerospace applications. In this contribution we will present the initial results of development at Luna Innovations of an all-fiber optic ultrasonic airframe SHM system that will be able to address the deficiencies of solutions suggested/developed to date. In this contribution we will present the details on design, development and testing of the prototype fiber optic SHM system.
Recent Development of Air-conditioning System Utilizing Electricity (2000)

The electric power consumption in the air-conditioning becomes a peak load to in the summer. The electric power facilities become excessive to the annual average load to be constructed according to the peak load and the operation percentage of the facilities has declined. Therefore, each electric power company is promoting to level the electric power load to achieve cheap supply of electric power. This paper introduces recent development of air-conditioning systems utilizing electricity, especially in Chubu Electric Power Co. These air-conditioning systems contribute electric power load leveling
Gestión de la salud, una perspectiva "ergológica”: cuántos gestos caracterizan una gestión (2015)

1. Introduccion En la tesis de doctorado presentada aqui se analizo una experiencia concreta de gestion en una organizacion publica de salud en Brasil, orientada por la demarche ergologica. La tesis (Souza, 2009) se origino a partir de la investigacion-intervencion llevada a cabo de 2005 hasta 2008 en un Centro Municipal de Salud (CMS), ubicado en un municipio del estado de Rio de Janeiro. El debate principal se desarrollo en torno del analisis de una modalidad de gestion, denominada ergogere...
11.GHz GaAs Power MESFET Load-Pull Measurements Utilizing a New Method of Determining Tuner Y Parameters (1979)

It has been shown that, in a symmetrical FET structure, the roles of the source and drain ohmic contacts may be interchanged by reversing the source–drain bias polarity. In power oscillator applications, this allows the realization of an optimally heat-sunk flip-chip common-drain circuit. Using this technique, both single-frequency and varactortuned high-frequency oscillators have been realized. It is felt that this technique will find wide usage in microwave oscillators because of the simplicity of the approach and the high performance possible. ACKNOWLEDGMENT
Monoclonal Anti-K14 and Anti-K2 (1987)

Mouse hybridoma clones have produced monoclonal antibodies directed against the K:14 and K:2 high-incidence antigens of the Kell blood group system. Two examples of anti-K14 were isolated, each arising from a separate fusion procedure. All three monoclonal antibodies are of the immunoglobulin class IgG1. Serological activity is consistent with that seen with human antibodies to high-incidence Kell system antigens, and their epitopes are destroyed, as usual, by 2-aminoethylisothiuronium bromide treatment. Specificity was further confirmed by adsorption and elution studies. Tests against nonhuman primate red cells demonstrated the expression of K:14 only by the great apes, whereas K:2 was present on all red cells tested. These findings emphasize the usefulness of monoclonal antibodies to elucidate the evolutionary patterns of blood group variants.
A Global Human Settlement Layer from optical high resolution imagery - Concept and first results (2012)

A general framework for processing of high and very-high resolution imagery for creating a Global Human Settlement Layer (GHSL) is presented together with a discussion on the results of the first operational test of the production workflow. The test involved the mapping of 24.3 millions of square kilometres of the Earth surface spread over four continents, corresponding to an estimated population of 1.3 billion of people in 2010. The resolution of the input image data ranges from 0.5 to 10 meters, collected by a heterogeneous set of platforms including satellite SPOT (2 and 5), CBERS-2B, RapidEye (2 and 4), WorldView (1 and 2), GeoEye-1, QuickBird-2, Ikonos-2, and airborne sensors. Several imaging modes were tested including panchromatic, multispectral and pan-sharpened images. A new fully automatic image information extraction, generalization and mosaic workflow is presented that is based on multiscale textural and morphological image features extraction. New image feature compression and optimization are introduced, together with new learning and classification techniques allowing for the processing of HR/VHR image data using low-resolution thematic layers as reference. A new systematic approach for quality control and validation allowing global spatial and thematic consistency checking is proposed and applied. The quality of the results are discussed by sensor, by band, by resolution, and eco-regions. Critical points, lessons learned and next steps are highlighted.
Mössbauer spectroscopy using synchrotron radiation (1991)

Delayed coherent nuclear forward scattering of synchrotron radiation by polycrystalline Fe foils (both isotopically enriched and naturally abundant) has been measured. Quantum beats wre observed in the time spectra. With the chosen experimental conditions these can only arise from coherent scattering. The 5-meV bandwidth provided by a special silicon crystal monochromator obviates the need for a nuclear resonant filter. This direct approach offers the possibility of performing a wide range of M\"ossbauer spectroscopy experiments using synchrotron radiation.
Lice of public health importance and their control (1973)

Lice have been intimately associated with man for centuries. Infestations with lice occur today in the United States and many other countries despite great efforts to maintain high standards of public health. Public health agencies are often called upon if infestations include or expose large groups of people, particularly those in public institutions such as schools, jails, hospitals, or homes for the aged. The three sucking lice that infest humans are: the body louse (Pedlculus humanus humanus), the head louse (Pediculus humanus capitis), and the crab louse (Pthirus pubis). The body louse is the species involved in epidemics of louseborne typhus, trench fever, and relapsing fever, but all three cause pediculosis. This manual covers the public health importance, biology, and control of these lice.
Structure of the O‐specific polysaccharide containing pentitol phosphate, isolated from <i>Hafnia alvei</i> strain PCM 1191 lipopolysaccharide (1993)

The O-specific polysaccharide of the lipopolysaccharide produced by Hafnia alvei strain PCM 1191 was shown by composition and methylation analyses, periodate oxidation and one- and two-dimensional 1H- and 31P-NMR spectroscopy to be a polymer of a branched hexasaccharide repeating units having the structure: [formula: see text] where LAraol = L-arabitol The polysaccharide of 1191 strain has teichoic-acid-like character. Its peculiar feature is the presence of arabitol phosphate, a component observed for the first time in bacterial lipopolysaccharides.
Herstellung und Umsetzungen von (<i>R,R</i>)‐ und (<i>S,S</i>)‐3‐Trifluormethyloxiran‐2‐carbonsäure‐ethylester, einem vielseitigen, leicht zugänglichen CF<sub>3</sub>‐haltigen Synthesebaustein (1992)

Preparation and Reactions of Ethyl ( R,R )‐ and ( S,S )‐3‐Trifluoromethyloxirane‐2‐carboxylate, a Versatile, Easily Accessible CF 3 ‐Containing Building Block for Synthesis A facile three‐step route has been elaborated leading from 4,4,4‐trifluoro‐3‐oxobutanoate to the trifluoro glycidic ester 1 mentioned in the title (0.1‐mole scale). Reactions with azide (→ 4, 5 ) and with organometallic compounds such as cuprates (→ 3, 6 ), lithium (→ 7, 8 ), and magnesium derivatives (→ 9–11 ) furnish novel enantiomerically pure trifluoromethyl‐substituted carboxylic esters, ketones, diols, and epoxy alcohols. The latter ones undergo selective isomerizations by Payne rearrangement ( 11 → 12 ) in aqueous NaOH/acetone or tert‐butyl alcohol.
Abstract 822: Withaferin A inhibits breast cancer invasion and metastasis at subcytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation (2011)

Abstract Withaferin A (WFA) is purified from the plant Withania somnifera and inhibits the vimentin cytoskeleton. Vimentin overexpression in cancer correlates with metastatic disease, induction of epithelial to mesenchymal transition, and reduced patient survival. Since WFA has significant anti-tumor activity and vimentin functions in cell motility, we wanted to test the hypothesis that WFA inhibits cancer metastasis by disrupting vimentin function. These data show that WFA has weak antiproliferative and apoptotic activity at concentrations less than or equal to 500 nM, but retains potent anti-invasive activity at these low doses. Live cell imaging in breast cancer cell lines revealed that WFA induces perinuclear vimentin bundling followed by rapid vimentin depolymerization. A concomitant induction of vimentin ser56 phosphorylation was observed, which is consistent with vimentin disassembly. Structure activity relationships were established using a set of chemically modified WFA analogs and showed that the predicted vimentin-binding region of WFA is necessary to induce vimentin ser56 phosphorylation and for its anti-invasive activity. Pharmacokinetic studies in mice revealed that WFA reaches peak concentrations up to 2μM in plasma with a half-life of 1.36 hours following a single 4 mg/kg dose. In a breast cancer metastasis mouse model, WFA showed dose-dependent inhibition of metastatic lung nodules and also induced vimentin ser56 phosphorylation, with minimal toxicity to lung tissue. Based upon these studies, we conclude that WFA is a potent breast cancer anti-metastatic agent and the anti-metastatic activity of WFA is, at least in part, mediated through its effects on vimentin and vimentin ser56 phosphorylation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 822. doi:10.1158/1538-7445.AM2011-822
320 Interaction between actin cytskeletal structure and Ca^<2+> dynamics during cell locomotion revealed by micro-patterning (2009)

IrtteraCtion between aCtin cytSikeleta structUre and
Ataxia‐telangiectasia: recommendations for multidisciplinary treatment (2017)

Ataxia-telangiectasia is a rare, neurodegenerative, and multisystem disease, characterized by cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, progressive respiratory failure, and an increased risk of malignancies. It demands specialized care tailored to the individual patient's needs. Besides the classic ataxia-telangiectasia phenotype, a variant phenotype exists with partly overlapping but some distinctive disease characteristics. This guideline summarizes frequently encountered medical problems in the disease course of patients with classic and variant ataxia-telangiectasia, in the domains of neurology, immunology and infectious diseases, pulmonology, anaesthetic and perioperative risk, oncology, endocrinology, and nutrition. Furthermore, it provides a practical guide with evidence- and expert-based recommendations for the follow-up and treatment of all these different clinical topics.
A 400 ps bipolar 18 bit RALU using advanced PSA (1980)

Describes a bipolar 18 bit register arithmetic logic unit (RALU) with 1300-gate complexity using an advanced bipolar process named Advanced PSA (APSA). The high-performance of the Advanced PSA transistor has made it possible to achieve a 400 ps delay time with 2.5 mW for a basic low level CML (LCML) circuit. The read-modify-write cycle time is 7 ns in an 18-bit ALU operation. Furthermore, with four RALU chips, a 72-bit ALU can be set up to operate at 100 MHz owing to the improved logic implementation. A 132 pin gang-lead bonding is employed for this LSI.
Inverse-multiplexing in multi-layer optical grooming networks (2004)

Optical DWDM technology has delivered immense scalability across long-haul and metropolitan core networks. However, since many client services still operate at slower speeds, there remains a large "granularity gap" with larger multi-gigabit wavelengths. Hence, various sub-rate grooming technologies have been developed to efficiently multiplex smaller demands on wavelengths and improve utilizations. The most notable such offering is "next-generation" SONET/SDH, which is now gaining significant market traction. A key feature of NGS is inverse multiplexing, which can resolve demands into smaller "subconnections." However, most studies on sub-rate grooming have not fully leveraged this vital addition. This paper presents a detailed initial look at inverse multiplexing in SONET/SDH-DWDM networks. Here, a novel grooming algorithm is tabled and its detailed performance is studied. Overall, results indicate notable improvements via the inverse multiplexing capability.
RADIATION-INDUCED CHANGES IN POLYMERS AND THEIR INFLUENCE ON GRAFT POLYMERIZATION (1963)

The preparation and irradiation behavior of a number of polymers, particularly those of the acrylate and methacrylate families, were studied. Panticular emphasis was placed on the role of structural factors and their importance in the investigation of radiation susceptibility. It was found that polymer molecular weight influences site formation. Site concentration is quite markedly affected by dose rate. Cyclization of the pendant-ester group has somewhat the same effect as has chain branching. Comparison of the EPR spectra of methacrylate polymers having cyclic ester groups with those having acrylic pendant structures suggests mechanistic differences associated with free-radical formation. Poly-2-hydroxypropylmethacrylate was examined in a continuation of investigations of structural effects and found to produce a type of EPR spectrum that would not be predicted from conventional structural considerations. In addition to an investigation of the mechanism of free-radical formation, postirradiation graft-copolymerization reactions were examined in some detail. Direct grafting methods as well as vaporphase and peroxide-initiated copolymerizations were studied. (auth)
Impact of the Cage Height, Diameter, and Positioning on Clinical and Radiographic Outcome of the Extreme Lateral Interbody Fusion (2015)

Introduction Extreme lateral interbody fusion (ELIF) is a novel technique for anterior spinal fixation and indirect decompression of neural elements. The aim of this study was to determine certain parameters of the interbody cage that would result in better radiographic and clinical outcomes. Patients and Methods We performed a retrospective analysis of 145 ELIFs in 90 patients. Intervertebral disc height, foraminal height, cage position, and lumbar lordosis were determined on preoperative, postoperative, and the latest follow-up studies. Clinical outcomes were evaluated by Oswestry Disability Index and Visual Analogue Scale. Results At the time of last follow-up (17.7 ± 1.1 months), two of the following factors determined restoration of foraminal height: the amount of increase in the disc height (implant height—preoperative disc height) and the footprint of the intervertebral spacer. Cages that had increased the disc height by 6 to 9 mm yielded in significantly greater restoration of foraminal height compared with the grafts that had increased the disc height by 0 to 3 mm ( p < 0.01) or 3 to 6 mm ( p < 0.05). In addition, 22 mm spacers allowed for a significantly higher increase in the foraminal height compared with 18 mm spacers ( p < 0.001). Interestingly, neither cage position nor posterior instrumentation had statistically significant influence on restoration of foraminal height. Both, lordotic and nonlordotic cages allowed for increased lumbar lordosis on postoperative imaging. Clinical evaluation revealed a mean ODI, VAS back, buttock, and leg pain improvements of 21.1%, 3.7, 3.6, and 3.7 points, respectively. Conclusions In ELIF, cage width and height but not cage position, determine restoration of foraminal height.
Integrated Automotive Electrontc Systems (2005)

The Evolution Of Electronics On The Automobile Has Been Slow And Frustrating For Both Automobile Engineers And The Electronic Manufacturers. This Presentation Discusses In Detail The Reasons For Con Sidering Sophisticated Electronics On The Automobile. Parallels Will Be Drawn To The Evolution Of Similar Technology In Other Sectors Of Business And Compari Sons Made To Determine The Reasons For The Slow Growth On The Automobile. Finally, This Presentation Will Look At Future Trends Covering How And Why The Electronics Technology Will Evolve In The Automobile Industry.
Fundamental Study for Time-Resolved Imaging by Laser Plasma X-rays (2003)

Laser plasma X‐ray, generated from solid targets irradiated by an intense short laser pulse, is an ultra‐short pulse with the time‐duration of about 10ps and enables time‐resolved measurements. For dynamic imaging using this laboratory‐scale source at Nuclear Engineering Research Laboratory (NERL), University of Tokyo, we have to increase the X‐ray intensity at least ten times more than present 3 ∼104 photons/cm2/shot at a sample. We carried out simulations of the interaction of a laser pulse with a solid target, which show that the number of hot electrons (>8keV for CuKα emission) become larger by decreasing the intensity of laser Amplified Spontaneous Emission. We have a plan to take time‐resolved images of laser ablation of solids with the time resolution of 10ps.