gebhart/patrepeval huggingface dataset:
Correlation between the sensitivity or resistance to IL‐2 and the response to cyclophosphamide of 4 tumors transplantable in the same murine host (1995)

We have studied the anti-tumor response to cyclophosphamide (CTX) in DBA/2 mice transplanted s.c. with 4 tumors exhibiting different responses to IL-2: ESb lymphoma and Friend leukemia cells (non-responsive or poorly responsive, respectively), p11-R-Eb and Eb lymphoma cells (both highly responsive to IL-2). CTX injections on days 7, 14 and 21 resulted in a significant anti-tumor response in mice transplanted s.c. with Friend leukemia cells or ESb cells, whereas no anti-tumor effect was observed in mice injected with Eb or p11-R-Eb cells. All 4 tumor cell lines were equally sensitive to the cytotoxic effects of mafosfamide, an in vitro active analogue of CTX. To define the host mechanisms responsible for the lack of an anti-tumor effect of CTX in mice transplanted with IL-2-responsive tumors, we studied several aspects of the spontaneous or IL-2-induced anti-tumor response in mice transplanted with p11-R-Eb cells. Injection of monoclonal antibodies (MAbs) to IFN-gamma completely abolished the anti-tumor effects of IL-2. Using a Winn assay, clear-cut anti-tumor activity was found in spleen cells from mice transplanted with the IL-2-responsive tumors. This activity was abolished by CTX, which also abrogated the anti-tumor response to IL-2 in mice injected with p11-R-Eb cells. Our results indicate an inverse correlation between sensitivity to IL-2 and response to CTX and emphasize the importance of initial host-tumor interaction in determining the type of response to IL-2 or CTX.
Manifold-enhanced Segmentation through Random Walks on Linear Subspace Priors (2013)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et a ̀ la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Suppression of SV40-promoted gene expression by differentiation of preadipose cells. (1988)

When a plasmid bearing the chloramphenicol acetyltransferase (CAT) gene under the control of an SV40 early promoter is introduced into preadipose or adipose cells of line 3T3-F442A, the promoter directs high levels of transient expression of CAT. However, when the plasmid is introduced into preadipose cells and the cells are then allowed to differentiate into adipose cells, the expression of the CAT gene is suppressed. In this process, the plasmid is not changed detectably in amount, topology, or state of methylation. Stably transformed preadipose cells bearing an integrated plasmid express the transferase, but if the cells are allowed to differentiate, the expression of the gene is similarly suppressed. The decline in CAT activity is associated with a decrease in the transcription rate of the gene. Transcription of a gene coding for neomycin phosphotransferase driven by the SV40 promoter is also greatly diminished by differentiation. Because suppression of CAT does not occur when the gene is under control of a retroviral long terminal repeat (LTR), a specific mechanism exists for the recognition and inactivation of the SV40 early promoter during differentiation.
EFFECT OF MESSENGER-TREATED TOMATOES ON BEET ARMYWORM (2002)

Seedlings were transplanted in a sandy loam type soil on 12 Jun at the University of California's South Coast Research and Extension Center. Experimental plots were four rows wide (5-ft centers) by 40 ft long and separated by a 5-ft buffer. The tomato transplants were drip irrigated (water pH 7.2-7.5). Treatments were replicated four times in an RCB design. A drench of Messenger at 9 oz./acre was applied to the tomatoes 1 wk before transplanting. Once the plants were in the field, the Messenger-sprayed treatments were initiated on an every-other-week basis at 4.5 oz/acre. Application dates were 26 Jun, 12 and 25 Jul, 9 and 23 Aug for a total of five post-transplant applications. A tractor-mounted boom sprayer with six nozzles per row incorporated D-3 orifice disks, #25 cores, and 50-mesh screens. Operating pressure was 100 psi delivering 100 gpa. All treatments received Activator 90 at 0.125% vol/vol as a spreader sticker. Additionally, a dechlorinator was used in the spray tank water.
Elucidating the Severity of Preclinical Traumatic Brain Injury Models (2014)

Future studies are needed to identify functional assessments, neurophysiologic techniques, and imaging assessments more apt to distinguish differences following so-called "mild" traumatic brain injury in preclinical models and determine whether these models are truly studying concussive or subconcussive injury. These studies are needed not only to understand the mechanism of injury and production of subsequent deficits, but also to rigorously evaluate potential therapeutic agents.
Notes - Derivatives of Sulfenic Acids. XXV. The Reaction of 1,2-Epoxides with 2,4-Dinitrobenzenesulfenyl Chloride (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Derivatives of Sulfenic Acids. XXV. The Reaction of 1,2-Epoxides with 2,4-Dinitrobenzenesulfenyl ChlorideD. Peters and N. KharaschCite this: J. Org. Chem. 1956, 21, 5, 590–593Publication Date (Print):May 1, 1956Publication History Published online28 February 2003Published inissue 1 May 1956https://pubs.acs.org/doi/10.1021/jo01111a610https://doi.org/10.1021/jo01111a610research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Clinical characteristics of anginal pain in man. (1989)

The clinical recognition of the cardiac origin of chest pain or discomfort on the basis of the description made by the patient, is often difficult. Nevertheless, considering the importance of the correct diagnosis of such syndrome, much work has been done in this field. In this report we will comment data from the literature and from our own, on the quality, duration, irradiation and on the precipitating or relieving factors that are more frequently associated with anginal pain.
<b>The Configuration of the Double Bond in Naturally-occurring Alkenyl Ethers</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Configuration of the Double Bond in Naturally-occurring Alkenyl EthersHuber R. Warner and William E. M. LandsCite this: J. Am. Chem. Soc. 1963, 85, 1, 60–64Publication Date (Print):January 1, 1963Publication History Published online1 May 2002Published inissue 1 January 1963https://pubs.acs.org/doi/10.1021/ja00884a012https://doi.org/10.1021/ja00884a012research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fast atom bombardment mass and tandem mass spectra of protonated and alkali cationized aldobiouronic and pseudoaldobiouronic acid per‐<i>O</i>‐methyl derivatives (1994)

Abstract The positive‐ion fast atom bombardment mass spectra of permethylated aldo‐ and pseudoaldobiouronic acids can be used to distinguish these classes of compounds. The collisional‐induced dissociation spectra of the [M + H] + ions show fragment ions resulting from glycosidic bond cleavage and successive losses of methanol molecules. These spectra together with those of the [M + H  MeOH] + oxonium ions allow the identification of the type of interglycosidic linkage. Collisional activation of the relatively stable [M + Na] + ions show many fragmentations which are common to alkali cationized permethylated saccharides. Moreover, fragment ions resulting from two‐bond ring cleavage processes yield additional information with respect to the linkage between the hexose and uronic acid units.
Hepatitis C Virus Glycoproteins Mediate Low pH-dependent Membrane Fusion with Liposomes (2005)

It has been suggested that the hepatitis C virus (HCV) infects host cells through a pH-dependent internalization mechanism, but the steps leading from virus attachment to the fusion of viral and cellular membranes remain uncharacterized. Here we studied the mechanism underlying the HCV fusion process in vitro using liposomes and our recently described HCV pseudoparticles (pp) bearing functional E1E2 envelope glycoproteins. The fusion of HCVpp with liposomes was monitored with fluorescent probes incorporated into either the HCVpp or the liposomes. To validate these assays, pseudoparticles bearing either the hemagglutinin of the influenza virus or the amphotropic glycoprotein of murine leukemia virus were used as models for pH-dependent and pH-independent entry, respectively. The use of assays based either on fusion-induced dequenching of fluorescent probes or on reporter systems, which produce fluorescence when the virus and liposome contents are mixed, allowed us to demonstrate that HCVpp mediated a complete fusion process, leading to the merging of both membrane leaflets and to the mixing of the internal contents of pseudoparticle and liposome. This HCVpp-mediated fusion was dependent on low pH, with a threshold of 6.3 and an optimum at about 5.5. Fusion was temperature-dependent and did not require any protein or receptor at the surface of the target liposomes. Most interestingly, fusion was facilitated by the presence of cholesterol in the target membrane. These findings clearly indicate that HCV infection is mediated by a pH-dependent membrane fusion process. This paves the way for future studies of the mechanisms underlying HCV membrane fusion.
Dry Eye Disease in Japan: An Epidemiologic Study (2009)

Purpose: To review our previous studies regarding the prevalence of dry eye disease (DED) and risk factors among Japanese high school students and office workers who use visual display terminals (VDTs). Methods: A cross-sectional survey was conducted in Japanese high school students and office workers who currently use VDT. Subjects completed the same questionnaires designed to ascertain a diagnosis of DED and its symptoms and information on possible risk factors such as age, duration of VDT use, type of VDT work, environmental factors, presence of systemic diseases, and contact lens (CL) use. We used logistic regression analysis to examine the associations between DED and other factors. Results: Among 3433 high school students assessed, severe symptoms of DED were observed in 21.0% of boys and 24.4% of girls. CL wear was associated with significantly higher prevalence of severe DED symptoms in both boys [odds ratio (OR), 4.14] and girls (OR, 4.68). Among 4393 VDT users, severe symptoms of DED were observed in 26.9% of men and 48.0% of women. VDT use > 4 hours per day was associated with increased risk of DED (OR, 1.83). Conclusion: DED is commonly encountered among Japanese high school students and VDT users. The condition is more prevalent among women, CL wearers, and prolonged VDT users.
Measurement of the Velocity of Particles Emerging from a Plasma Flame by High-Speed Cine-Streak Photography (1971)

Glass beads of 30- to 140-μm diameter and 50 to 100 m/s velocity emerging from a plasma flame (10,000 K) were photographed using a 16mm high-speed ciné camera in streak mode. The combined radiation from the hot particles and that reflected from the flame provided sufficient light intensity using 400 ASA reversal film. The narrow depth of field (±5 mm) was investigated using an illuminated spinning disc having a hole the same size as the particle. A stereo streak system was devised for particle location in two dimensions. Ghost images caused by internal lens reflection were identified on the film. A simple system for film analyzing was built and a semiautomatic electrical disc analog for measuring streak angle was devised and tested. Overall optical resolution was sufficient to enable particle accelerations (2,000 g) to be estimated from the changes of streak angle across the film.
Change In Use Of Land: A Practical Guide to Development in Hong Kong (2005)

This volume provides a guide to tackling the concept of land use and the change in use of land in Hong Kong.
Photovoltaics for rural electrification in the People's Republic of China (2002)

Rapid growth in economic development, coupled with the absence of an electric grid in large areas of the rural countryside, has created a need for new energy sources both in urban centers and rural areas in China. The most critical need for rural electrification exists in northern and western China, where 80 million people had no access to grid electricity at the end of 1995. In February 1995, the US Department of Energy signed an Energy Efficiency and Renewable Energy Protocol Agreement with the Chinese State Science and Technology Commission in Beijing. Under this agreement, NREL is providing assistance to several central government and provincial government agencies in China to develop photovoltaic and photovoltaic hybrid applications for rural electrification.
Low noise HgCdTe 128 x 128 SWIR FPA for Hubble space telescope (1989)

Large area focal plane arrays of unprecedented performance were developed for use in Near Infrared Camera and Multi-Object Spectrometer (NICMOS), a proposed Hubble Space Telescope refurbishment instrument. These FPAs are 128x128-element, HgCdTe hybrid arrays with a cutoff wavelength of 2.5 microns. The multiplexer consists of a CMOS field effect transistor switch array with a typical mean readout noise of less than 30 electrons. The detectors typically have a mean dark current of less than 10 electrons/s at 77 K, with currents below 2 electrons measured at 60 K (both at 0.5 V reverse bias). The mean quantum efficiency is 40 to 60 percent at 77 K for 1.0 to 2.4 microns. Functional pixel yield is typically greater than 99 percent, and the power consumption is approximately 0.2 mW (during readout only).
Mixed work and relaxation photos (1920)

Photos from an album of mixed work and relaxation photos taken by Roy Edwards in NT in the 1920s.
Enhanced<i>O</i>-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles (2002)

O-linked glycosylation on Ser/Thr with single N-acetylglucosamine (O-GlcNAcylation) is a reversible modification of many cytosolic/nuclear proteins, regulated in part by UDP-GlcNAc levels. Transgenic (T) mice that overexpress GLUT1 in muscle show increased basal muscle glucose transport that is resistant to insulin stimulation. Muscle UDP-GlcNAc levels are increased. To assess whether GLUT4 is a substrate for O-GlcNAcylation, we translated GLUT4 mRNA (mutated at the N-glycosylation site) in rabbit reticulocyte lysates supplemented with [(35)S]methionine. O-GlcNAcylated proteins were galactosylated and separated by lectin affinity chromatography; >20% of the translated GLUT4 appeared to be O-GlcNAcylated. To assess whether GLUT4 or GLUT4-associated proteins were O-GlcNAcylated in muscles, muscle membranes were prepared from T and control (C) mice labeled with UDP-[(3)H]galactose and immunoprecipitated with anti-GLUT4 IgG (or nonimmune serum), and N-glycosyl side chains were removed enzymatically. Upon SDS-PAGE, several bands showed consistently two- to threefold increased labeling in T vs. C. Separating galactosylated products by lectin chromatography similarly revealed approximately threefold more O-GlcNAc-modified proteins in T vs. C muscle membranes. RL-2 immunoblots confirmed these results. In conclusion, chronically increased glucose flux, which raises UDP-GlcNAc in muscle, results in enhanced O-GlcNAcylation of membrane proteins in vivo. These may include GLUT4 and/or GLUT4-associated proteins and may contribute to insulin resistance in this model.
Study on the growth of rickettsiae. III. Influence of extracellular environment on the growth of Rickettsia tsutsugamusni in tissue culture cells. (1959)

It is postulated here that the role of the adequately nourished host cell may be more than nutritional in supporting rickettsial survival in that it provides an environment which protects the rickettsiae from loss of their essential components by leaching.
Effect of N doping on the electron emission properties of DLC Film on 2-inch Mo FEAs panel (1997)

We have studied on the enhancement of field emission characteristics by hydrogen-free Ndoped diamond-like carbon (DLC) coating on MO-tip field emitter arrays by a layer-by-layer technique using plasma enhanced chemical vapor deposition. The Spindt-type Molybdenum tip is used as a emission source without resistive layer on silicon substrate. The maximum emission current for each pixel was increased from 160pA to lS20pA by 20nm N-doped DLC coating., Furthermore, the emission current from DLC coated FEAs is more stable than that of non-coated FEAs.
Les prestations familiales, la hiérarchie des revenus et les inégalités sociales en Saône-et-Loire (1977)

Bouvy Alain, Lepère Robert, Steck Philippe, Vienot Alain. Les prestations familiales, la hiérarchie des revenus et les inégalités sociales en Saône-et-Loire. In: Economie et statistique, n°89, Mai 1977. pp. 69-74.
Implementation of MLSE equalizer in optSim and evaluation of its performance (2005)

Empyema due to Hemophilus influenzae has been reported only rarely. This report describes the cases of ten children with empyema due to this organism. Diagnosis was made through growth of the organism in pure culture from pleural effusion. H. influenzae empyema may occur in older children as well as in infants and, in contrast to certain other infections with this organism, empyema due to H. influenzae may be more common than is generally suspected.
Wavelet based sensor fusion for tool condition monitoring of hard to machine materials (2015)

Tool condition monitoring in modern manufacturing systems is gaining more attention due to the fact that excessive tool damage can cause workpiece surface deterioration and increase idle time. Therefore, monitoring tool condition from the initial to final stages of tool life is a task that is critical yet difficult, especially in hard-to-machine materials. In this work, Wavelet Packet Decomposition is used for extracting statistical features in the time-frequency domain of two low cost sensing technologies, i.e. vibration and power, in addition to Principal Component Analysis to reduce the dimensionality of feature vectors. A Recurrent Neural Network is then trained with Bayesian regularization backpropagation method and the estimated tool wear is compared to the actual measured wear. Results show a maximum of 13% relative error in estimating tool wear which proves the effectiveness of implemented sensory data fusion method to be used in automated control of manufacturing processes.
Native Hydrophobic Interaction Chromatography Hyphenated to Mass Spectrometry for Characterization of Monoclonal Antibody Minor Variants (2019)

Conventionally, hydrophobic interaction chromatography (HIC) uses mobile phases with high salt concentration that are not compatible with mass spectrometry (MS). Here we describe development of an HIC method coupled with MS detection (HIC-MS) utilizing an aqueous mobile phase with a low concentration of a volatile salt for characterizing recombinant monoclonal antibody (mAb) post-translational modifications (PTMs). The ability of HIC to separate the oxidation and free thiol variants of the mAbs enables their isolation and rapid characterization of these attributes under native conditions, an important step toward understanding the role they play.
A Multidisciplinary Approach to the Evaluation and Treatment of Temporomandibular Joint and Cervical Spine Dysfunction (1989)

This article presents a multidisciplinary approach to the management of temporomandibular joint (TMJ) and cervical spine dysfunction in a heterogeneous population of patients. A methodology for the systematic evaluation and treatment of patients is outlined; case histories are used to illustrate the workings of the model. A study to assess the efficacy of treatment was performed on 27 female and three male adult patients. Results indicated that patients achieved an 87% recovery rate at discharge with an 83% success rate six months after discharge. A control study was undertaken using 16 female and three male adults to establish indications for TMJ occlusal splint therapy in patients who present with questionable TM dysfunction. The multidisciplinary model presented in this article provides a system of patient evaluation and treatment that can be easily adopted by clinicians involved in a team approach to TMJ and cervical spine dysfunction.
Antibacterial Activity of Several Organic Acids Commonly Used as Food Additives (1995)

Among 9 organic acids commonly used as food additives in Japan, fumaric acid (FA) exhibited the strongest growth-inhibiting (GI) action on 20 Gram-negative bacterial strains tested. Growth of these 20 strains, including 3 Salmonella serovars, Escherichia coli, E. cloacae, Klebsiella oxytoca, K. pneumoniae, Acinetobacter anitratus, Proteus mirabilis, or Pseudomonas aeruginosa, was inhibited within 160 seconds of contact with 0.3w/v% solution of FA, although strains of S. Typhimurium exhibited lower susceptibility than the others. Both Bacillus cereus and Staphylococcus aureus were resistant to the GI action of FA and other organic acids. The GI action of FA was remarkably improved by the addition of 0.3-0.1% ascorbic acid, malic acid, tartaric acid or citric acid monohydrate.
Radioactive threat detection with scattering physics: A model-based application (2010)

The detection of radioactive contraband is a critical problem in maintaining national security for any country. Emissions from threat materials challenge both detection and measurement technologies especially when concealed by various types of shielding complicating the transport physics significantly. The development of a model-based sequential Bayesian processor that captures both the underlying transport physics including scattering offers a physics-based approach to attack this challenging problem. It is shown that this processor can be used to develop an effective detection technique.