gebhart/patrepeval huggingface dataset:
Creation de modeles de cancers chez des souris transgeniques et etude de la regulation transcriptionnelle du gene de la pyruvate kinase de type l dans le pancreas (1996)

Des modeles murins d'hepato-carcinomes et de tumeurs endocrine du pancreas, facilement inductibles par le regime alimentaire, ont ete obtenus par oncogenese ciblee. Pour cela, les oncogenes myc et les antigenes t et t de sv40 s'expriment sous le controle des sequences regulatrices du gene de la pyruvate kinase l (l-pk). Grace a ces modeles, nous avons pu mettre en evidence que le gene de la l-pk s'exprime non seulement dans le foie, le rein et l'intestin mais aussi dans les ilots de langerhans. Les mecanismes moleculaires par lesquels le gene de la l-pk s'exprime dans le pancreas et dans les differents derives de l'intestin primitif ont ete abordes par des methodes d'analyses d'interaction adn-proteines in vitro et in vivo, et par la creation de nouveaux modeles de souris transgeniques chez lesquelles des sequences oncogeniques ont ete placees sous le controle de sequences regulatrices hybrides. L'analyse des resultats montre que le profil d'expression du gene de la pk-l depend de deux sequences regulatrices distinctes. Premierement, il existe une correlation entre le niveau d'expression de la pk-l dans les tissus riches en facteur hnf1 et la proportion du facteur hnf4, tous les deux se fixent au niveau du promoteur proximal. Deuxiemement, une region situee a 3kb en amont contient des elements importants pour assurer la specificite pancreatique d'expression du gene de la l-pk. De plus, de nouveaux modeles d'oncogenese ciblee utilisant d'autres sequences oncogeniques ou des sequences regulatrices hybrides, nous ont permis d'obtenir de nouveaux types de cancers murins en souris transgeniques comme des thymomes, des lymphomes et des nephroblastomes.
Aptamer-based surface-enhanced resonance Raman scattering assay on a paper fluidic platform for detection of cardiac troponin I (2020)

The aptamer-based SERRS assay on a paper strip has the potential to provide a sensitive, selective, stable, repeatable, and cost-effective platform for the detection of cTnI toward eventual use in diagnosis of MI at the POC.
RRT*N: an efficient approach to path planning in 3D for Static and Dynamic Environments (2020)

In this paper, a modified algorithm of the Rapidly exploring Random Tree star (RRT*) is proposed. This method is called RRT*N. The main advantage of this method is its speed and robustness in finding the path to the target. An extension of this method to the 3D case is also presented and its capability of handling static obstacles and dynamic unknown moving obstacles in 2D and 3D environments, is shown. This improved method uses a probability distribution to generate new nodes. The nodes closest to the target have higher probability, which generates a tree centered on the line joining the robot to the target. It is shown that this method can be three times faster in finding the path to the target than the regular RRT* in the same environment. Simulation and experimental results are presented to show the robustness of the proposed RRT*N method.
Molecular Rotors in Porous Organic Frameworks (2014)

Abstract Porous organic frameworks perform a variety of functions, owing to their extremely large surface areas, but the dynamics of the structural elements have never been explored. Our discovery of ultra‐fast molecular rotors (10 6 Hz at 225 K) in their architectures allows us to look at them from a new perspective. The constructive elements are robust struts and rapid rotors, resulting in a dynamic material whose motion can be frozen or released at will. The rotational motion can be actively regulated in response to guests. As the temperature is increased, the rotors spin ever faster, approaching free‐rotational diffusion at 550 K. The unusual combination of remarkable nanoporosity with fast dynamics is intriguing for engineering oscillating dipoles and producing responsive materials with switchable ferroelectricity, and for applications spanning from sensors to actuators, which capture and release chemicals on command.
7-Methoxy-2,3-dioxo-1,4-dihydroquinoxalin-6-aminium chloride monohydrate (2009)

Single crystals of the title compound, C(9)H(10)N(3)O(3)(+).Cl(-).H(2)O, were obtained by recrystallization from hydrochloric acid. The cations stack along the crystallographic a direction. The 2,3-dioxo-1,4-dihydroquinoxaline group shows a significant deviation from planarity [r.m.s. deviation from the best plane = 0.063 (2) A]. Hydrogen bonding links the cations, chloride anions and water molecules to form an extended three-dimensional architecture.
Newgate (1994)

I n the autumn of 1835, Dickens (then aged twenty-three) was excitedly planning his first book, Sketches by Boz, which appeared the following February. It consisted mainly of essays and stories contributed to various journals over the previous two years, but, as he explained to his publisher, Macrone, he would add a few pieces to fill out the two volumes. In particular, he was seeking permission to go over Newgate — 'I have long projected sketching its Interior, and I think it would tell extremely well.' Three weeks later, he had finished writing 'a long paper' on this subject, entitled 'A Visit to Newgate', and was very anxious for Macrone to see a corrected proof of it, for two experienced journalists had already praised it highly, assuring him that 'it would "make" any book'. Further letters written before the book was published refer to his gratification at Macrone's and Harrison Ainsworth's opinions of this piece, and then the critics kindly reiterated in public the view that this was 'the most remarkable paper in the book.… It is written throughout in a tone of high moral feeling, and with great eloquence, and must leave a deep and lasting impression on the mind of every reader'.1 KeywordsLiterary SkillNews LetterCentral SymbolEstablished AuthorityDelinquent GirlThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Determination of local radiative properties in coal-fired flames: Technical progress report, third quarter of the first year, March 15--June 15, 1988 (1988)

Main interest in the project is to determine the radiative properties of coal particles in situ and establish a data bank for radiative properties of different coal types. During the last three months, we have continued setting up the experiment and have worked on analytical inverse solution techniques. Recently, experiments on the pulverized-coal-fired burner have been started. These experiments are mainly preliminary test runs, and because of this we do not present any data in this report. Instead, we only describe the burner and the fluidized-bed coal feeder. Meanwhile, we continue working on the analytical techniques for the solution of the inverse radiation problem. 4 refs., 6 figs.
Factors influencing the cellular location of proteolytic enzymes of Bacillus intermedius. (2001)

Thiol-dependent serine proteinase and glutamylendopeptidase of Bacillus intermedius 3-19 being prevailing enzymes in the total pool of extracellular proteinases (95%) of this microorganism in catalytic active form were detected on the membrane of the cells. Production of these enzymes was maximum on the medium containing inorganic phosphate and gelatin and decreased 2-4-fold on the medium with glucose and lactate. The level of the activity of extracellular enzymes correlated with that of corresponding membrane-bound proteins. The addition of CoCl2 (2 mM) into the medium caused essential increase in extracellular glutamylendopeptidase activity and promoted the release of membrane-bound enzyme into cultural fluid. Proteolytic activity was detected in cytoplasm also. Proteinases localized in cytoplasm were shown to differ in properties from those secreted.
Purging Musical Instrument Sample Databases Using Automatic Musical Instrument Recognition Methods (2009)

Compilation of musical instrument sample databases requires careful elimination of badly recorded samples and validation of sample classification into correct categories. This paper introduces algorithms for automatic removal of bad instrument samples using automatic musical instrument recognition and outlier detection techniques. Best evaluation results on a methodically contaminated sound database are achieved using the introduced MCIQR method, which removes 70.1% "bad" samples with 0.9% false-alarm rate and 90.4% with 8.8% false-alarm rate.
Eiffel Linda (1990)

Eiffel is a statically-typed object-oriented language which supports good software engineering techniques but provides no support for concurrency; Linda is a parallel programming model which provides a uniform semantics for coordination and communication among multiple processes. This paper describes an Eiffel Linda which injects the Linda operations into the Eiffel language. The resulting synthesis extends both Eiffel and Linda; the implications of the synergy between the two systems are examined, and suggestions for future work are proposed.We begin with an examination of the Eiffel execution model, with particular reference to its emphasis on the correct construction of software systems. We briefly describe the Linda language, and compare it to other parallelism models. The unified Eiffel Linda language is then presented, with discussion of the semantic issues which were considered in the course of its evolution, and details of the interesting features of our particular implementation. Comparisons to past work in Linda and in object-oriented concurrency are offered. In conclusion, we reflect on the significance of Eiffel Linda, and consider its relevance to future work in object-based concurrency.
ChemInform Abstract: Reactions of Dimethoxycarbene with Cyclic Perchlorinated Olefins and Ketones. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental quantum key distribution at 1.3 gigabit-per-second secret-key rate over a 10 dB loss channel (2018)

Quantum key distribution (QKD) enables unconditionally secure communication ensured by the laws of physics, opening a promising route to security infrastructure for the coming age of quantum computers. QKD's demonstrated secret-key rates (SKRs), however, fall far short of the gigabit-persecond rates of classical communication, hindering QKD's widespread deployment. QKD's low SKRs are largely due to existing single-photon-based protocols' vulnerability to channel loss. Floodlight QKD(FL-QKD) boosts SKR by transmitting many photons per encoding, while offering security against collective attacks. Here, we report an FL-QKD experiment operating at a 1.3 Gbit s(-1) SKR over a 10 dB loss channel. To the best of our knowledge, this is the first QKD demonstration that achieves a gigabit-per-second-class SKR, representing a critical advance toward high-rate QKD at metropolitan-area distances.
Abstract 14926: Absence of Adventitial Vasa Vasorum Formation at the Coronary Segment With Myocardial Bridge -An Optical Coherence Tomography Study (2017)

Background: Myocardial bridge (MB) is a myocardial bundle through which coronary segment tunnels and could compress coronary arteries causing myocardial ischemia. However, the characteristic findin...
Tailoring Electron Diffusion in Electrospun Metal Oxide Nanostructures for Dye-sensitized Solar Cells (2011)

Metal oxide wide bandgap semiconducting nanostructures lie at the heart of many technologies including dye-sensitized solar cells (DSCs), they act as charge separation and transport medium; and therefore, understanding and controlling charge transport is key to increase the performance level of corresponding devices beyond current thersholds. Unlike bulk semiconductors, in which the electrons diffuses in the conduction band from one transport state to another, electron transport in nanostructured materials occurs through the localized surface energy states that lie within the bandgap. This article focus on the advances made on controlling the charge transport in electrospun metal oxide nanostructures.
ChemInform Abstract: Synthesis of Novel Bicyclic Nitroxides Using Partial Favorskii Rearrangement. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of a Gene Therapy Strategy for the Restoration of Survival Motor Neuron Protein Expression: Implications for Spinal Muscular Atrophy Therapy (2003)

Spinal muscular atrophy (SMA) is a motor neuron degeneration disorder, and manifests itself in patients as muscle weakness and paralysis that ultimately leads to death. Currently, there is no effective treatment for this disease. As a first step in developing a treatment for SMA, we are examining whether delivery of the gene encoding survival motor neuron (SMN) protein to primary fibroblast cell lines derived from SMA patients can lead to restoration of nuclear-staining foci, called gems, which are absent in patients with severe SMA. Using adenovirus-mediated gene delivery, we show that SMN can be efficiently expressed in patient fibroblasts, and leads to restoration of nuclear gems, which are thought to be important for the functional rescue of the SMA phenotype. The number of gems per cell is equal to or greater than those found in fibroblasts of normal individuals. Furthermore, ectopic expression of SMN also caused relocalization of Gemin2, an SMN-interacting protein, to gems. Overall, this work is the first demonstration of the feasibility of virus-based delivery of the SMN-coding gene to restore the normal SMN expression pattern in SMA patient-derived cells, and holds promise for gene therapy of SMA, as a potential long-term therapy for this devastating childhood disease.
Motif mimetic of epsin perturbs tumor growth and metastasis (2016)

During the assembly of Figure In addition, a different replicate is now provided for the Tg sm/p22phox sample in Figure The correct figure panels are below.
Analysis of DNaseI Hypersensitive Sites in Chromatin by Cleavage in Permeabilized Cells (2003)

Treatment of nuclei with limited amounts of DNaseI can be used to reveal sites in chromatin that are hypersensitive (HS) to the nuclease (1,2). DNaseI HS sites are thought to correspond to sites where the regular nucleosome structure is perturbed, e.g., by binding of proteins to chromatin such that DNA becomes more accessible to the nuclease. Some HS sites have indeed been reconstituted in vitro during assembly of nucleosomes in the presence of transcription factors. Mapping of DNaseI HS sites and monitoring their time course of appearance (or disappearance) has been successfully used to identify many regulatory elements. Analysis of HS sites is an attractive method when searching for regulatory regions because one can scan genomic regions without detailed prior assumptions of where to look.
Cell-mediated immunity and its role in resistance to infection. (1977)

The recently acquired knowledge of the importance of cell-mediated immunity in many illnesses and the discovery of a variety of substances that can restore certain cell-mediated immune functions has served to focus the attention of physicians on this area of immunity. It is important for practicing physicians to have a clear understanding of current knowledge of the role of cell-mediated immunity in resistance to infection and how this arm of the immune system relates to the diagnosis and therapy of infectious diseases.
Control of <i>Rosollinia necatrix</i> by Deep Placement and Hot Treatment with Methyl Bromide<sup>1</sup> (1983)

Rosellinia necatrix , the cause of white root rot in fruit trees, was efficiently controlled in an infested avocado orchard soil, by applying methyl bromide by deep injection (up to 90 cm) of cold gas and by surface application of hot gas, at a dosage (for heavy soil) of 1500 kg/ha and 1000 kg/ha, respectively. Efficiency of control was evaluated: 1) by testing pieces of naturally diseased avocado roots buried in the soil before treatment at different depths up to 100 cm; 2) by planting avocado and almonds in the treated field and in soil samples; 3) by burying avocado leaves in the soil samples. All the evaluaton tests showed that both treatments of methyl bromide were effective in controlling R. necatrix completely up to the depth of 100 cm, immediately and 9 months after treatment.
DESIGN AND ANALYSIS OF INSTRUMENTED SUBASSEMBLY SYSTEM FOR EBR-II. (1968)

be attained during reactor operation. Temperatures above and below this range would cause heat transfer or stress problems. It is intended to make it possible to remove and insert individual tests without effecting the remaining instruments being tested.
DEVELOPMENT AND PROPERTIES OF URANIUM-BASE ALLOYS CORROSION RESISTANT IN HIGH TEMPERATURE WATER. PART IV. RADIATION STABILITY OF URANIUM-BASE ALLOYS (1957)

The effects of pile irradiations on the physical properties and corrosion resistance of U-- Mo, U-- Nb; and U--Si alloys are reported. The dimensional stability under irradiation of the gamma phase U-- Mo and U-- Nb alloys is excellent; however, an isotropic volume increase of 4 to 6% per wt.% burnup may limit the ultimate fuel element life. Corrosion resistance of the gamma-phase alloys appesrs to be improved when subjected to s neutron field; this is attributed to an irrsdiation induced stabilization of the gamma phases. The U/ sub 3/Si alloy, on the other hand, suffered severe deterioration, particularly of corrosion resistance. Changes in electrical resistivity, hardness, mechanical properties, and crystal structure are presented and the mechanisms producing the observed changes discussed. (auth)
ChemInform Abstract: AN INTRAMOLECULAR 1,3‐HYDRIDE SHIFT IN THE ADAMANTANE NUCLEUS (1973)

Abstract Das Glykol (II), das korrespondierende Epoxid (I) oder der Spirocyclus (III) in der Adamantanreihe werden bei der Behandlung mit 50%iger Schwefelsäure bei 140°C unter Hydrid‐Verschiebung in ein Gemisch aus (III) und dem Diadamantanon (IV) umlagert.
A statistical interface for historical relational databases (1987)

A historical database is a vast source of data for statistical analysis. The paper presents a statistical interface for historical relational databases with an underlying data model which uses attribute time-stamping. The statistical interface we propose includes aggregate functions and transformations of data into tabular forms suitable for advanced statistical analysis and is capable of dealing with the subtle semantics of time and various issues associated with it. A new operation, called enumeration, is introduced into historical relational algebra. The enumeration operation derives a table of uniform data, for a set of specified time points or intervals, from a three dimensional historical relation. We also give a method for normalizing historical relations and aligning the time of their attributes.
Epizootic caused by β-Haemoltytic Streptococcus Species in Cultured Freshwater Fish (1981)

Streptococcal infections have been frequently observed in cultured freshwater fish, tilapia (Tilapia nilotica), rainbow trout (Salmo gairdneri) and ayu (Plecoglossus altivelis) at farms in various districts of Japan. The causative agents isolated from diseased tilapia, rainbow trout and ayu had the same morphological as well as biochemical characteristics. All the strains were also serological homogeneous. These strains were found to be pathogenic to freshwater fish after intraperitoneal injection. The autoclaved and hot-HCl treated cells did not react with any of the group specific sera used: Lancefield A, B, C, D, E, F, G, H, K, L, M, N, O and MG. This organism was not identical to any strains of Streptcoccus previously reported.
First-principles study of microscopic models of the Si(001)-SiO2 interface. (1995)

We have studied structural and electronic properties of models of abrupt interfaces between Si(001) and Si0₂ within density functional theory in the local density approximation. We have adopted a model interface between Si and tridymite, a crystalline form of Si0₂, and have allowed for full relaxation. We find structures in which all dangling bonds are saturated. Comparison between calculated and experimental x-ray scattering intensities seems to rule out the tridymite hypothesis. On the other hand, the absence of electronic states in the Si gap indicates that our model interface is a valuable starting point for further investigations.
A new method for determining sample thickness: A comparison to experimental results (1993)

Sample thickness is an important parameter in quantitative electron microscopy,. Several methods for determining sample thickness have been described previously. A theoretical method presented here utilizes the low loss region of the electron energy loss spectrum to calculate sample thickness. The method avoids many of the limitations of other methods and is applicable to a wide variety of samples. The method is compared to film thicknesses determined experimentally as described below. Chromium films were deposited simultaneously onto collodion supported TEM grids and cured epoxy blanks using a Denton Hi Res 100 coater equipped with a Syton quartz crystal monitor. The cured epoxy blanks were covered with a layer of unpolymerized epoxy that was then cured. The chromium sandwich was cross sectioned using ultramicrotomy techniques employing a diamond knife. Sections were produced which were as thin as possible (<50 nm) to minimize measurement errors. Chromium film thickness was determined directly using transmission electron microscopy (Fig. 1).
A Case of Plasmodium falciparum Malaria Successfully Treated with Halofantrine (1994)

A 44-year-old male, who had been to Lagos, Nigeria, was admitted to our hospital because of a high grade fever on July 20, 1993. On admission, Plasmodium falciparum was detected in his blood smears and the antibody titers against P. falciparum and Plasmodium vivax antigens were 1:256 and < 1:4 respectively by the indirect fluorescent antibody test. Therefore, he was diagnosed as having P. falciparum malaria. He was treated with halofantrine (Halfan: Smith Kline Beecham Pharmaceuticals, England), two tablets at six-hourly intervals, a total of six tablets (1500 mg). Parasites were cleared rapidly and remission was achieved without any adverse reactions. Halofantrine can therefore be recommended for the treatment of imported P. falciparum malaria.
High-bandwidth velocity-matched optical directional coupler modulator in AlGaAs/GaAs (1992)

We report a design of a very high frequency A1GaAs/GaAs optical modulator using a dielectric loading velocity matching technique. The optical modulator is a directional coupler which is covered with a thin coating of Ta2O5 to match the velocities of the lightwave and the if modulating signal to within 2%. The optical and rf characteristics of the modulator are analyzed using the effective index and finite difference methods. The small signal 3 dB bandwidth for the modulator is predicted to exceed 45GHz and 100 GHz for biasing at the null point and in the linear region respectively, with a maximum modulation voltage of 5V at 830nm wavelength.