gebhart/patrepeval huggingface dataset:
Purification and Characterization of Lysine- and Arginine-Specific Gingivain Proteases from<i>Porphyromonas Gingivalis</i> (1994)

Four gingivain proteases, active in presence of L-cysteine, were purified from spent culture media of oral pathogen Porphyromonas gingivalis by ion-exchange chromatography on MonoQ and chromatofocusing on MonoP columns. Three of the purified proteases, with molecular masses of 75 kDa, 70 kDa and 55 kDa, respectively, hydrolyzed synthetic chromogenic substrates with arginine in the P1 position. One protease, with a molecular mass of 80 kDa, hydrolyzed substrates with lysine in the P1 position. It is proposed these enzymes be named: arg-gingivain-75, arg-gingivain-70, arg-gingivain-55, and lys-gingivain-80, respectively, based on their molecular mass and specificity for either arginine or lysine in the P1 position.
Equalization for DMT based broadband modems (2000)

Faced with fierce competition from cable operators, telephone companies are now aggressively investing in digital subscriber line technology with the objective of providing an economic broadband access alternative. However, high-bit-rate transmissions over the metallic access network is far from trivial. The subscriber loop predominantly consists of interconnection of twisted pair copper sections. This causes severe attenuation of the high-frequency components of the transmitted signal. Equalization refers to the signal processing in the transceiver to combat the effects of the dispersive channel on the transmitted signal. This article overviews equalization methods for discrete multitone modulation (DMT). The interference structure created by a non-ideally equalized channel is analyzed. Time modulation as well as frequency domain equalization methods are addressed.
Cross channel optimized marketing by reinforcement learning (2004)

The issues of cross channel integration and customer life time value modeling are two of the most important topics surrounding customer relationship management (CRM) today. In the present paper, we describe and evaluate a novel solution that treats these two important issues in a unified framework of Markov Decision Processes (MDP). In particular, we report on the results of a joint project between IBM Research and Saks Fifth Avenue to investigate the applicability of this technology to real world problems. The business problem we use as a testbed for our evaluation is that of optimizing direct mail campaign mailings for maximization of profits in the store channel. We identify a problem common to cross-channel CRM, which we call the Cross-Channel Challenge, due to the lack of explicit linking between the marketing actions taken in one channel and the customer responses obtained in another. We provide a solution for this problem based on old and new techniques in reinforcement learning. Our in-laboratory experimental evaluation using actual customer interaction data show that as much as 7 to 8 per cent increase in the store profits can be expected, by employing a mailing policy automatically generated by our methodology. These results confirm that our approach is valid in dealing with the cross channel CRM scenarios in the real world.
The Deregulation of International Satellite Communications. (1984)

In an explorative study for new anti-malarial substances using the methyl esters (1 and 2) of peroxyplakoric acids A(3) and B(3) as scaffolds, 6-carbomethoxymethyl-3-methoxy-3-pentyl-1,2-dioxane, which has been readily synthesized from 6-keto-alpha,beta-unsaturated ester, was found to exhibit potent anti-malarial activity with high selective toxicity.
Operative strategies in ontological semantics (2003)

In this paper, we briefly and informally illustrate, using a few annotated examples, the static and dynamic knowledge resources of ontological semantics. We then present the main motivations and desiderata of our approach and then discuss issues related to making ontological-semantic applications feasible through the judicious stepwise enhancement of static and dynamic knowledge sources while at all times maintaining a working system.
Screening for soluble methane monooxygenase in methanotrophic bacteria using combined molecular and biochemical methods for hydroxylase detection (2003)

Three well known methanotrophic bacteria (Methylosinus trichosporium OB3b, Methylocystis sp. WI 14, and Methylocystis sp. GB 25) and three newly isolated methanotrophic bacteria (Methylocystis sp. WI 11, Methylocystis sp. X, and FI-9) were screened for sMMO considering the existence of hydroxylase (component A) genes as well as its gene expression. For these purposes monoclonal antibodies that specifically recognize each subunit of the hydroxylase of Methylocystis sp. WI 14 (alpha-subunit [9E5/F2], beta-subunit [4E2/G11], gamma-subunit [10G3/D7]) were produced. PCR amplification using well known primers showed that the hydroxylase encoding genes appear to be only present in M. trichosporium OB3b, Methylocystis sp. WI 11 and WI 14, and in the isolate FI-9. Western and ELISA analysis using the monoclonal antibodies revealed that all subunits of hydroxylase were present. However, in FI-9, only the alpha-subunit of the hydroxylase might be expressed. Surprisingly, in Methylocystis sp. GB 25, where no sMMO activity and no amplification with sMMO specific primers was obtained, the antibody 4E2/G11 recognized a protein band with exactly the same molecular mass as the beta-subunit of the hydroxylase. Methylocystis sp. X showed no positive reaction in any of the tests. In combination with the detection methods currently used, the described antibodies provide a powerful tool for detecting even partially expressed hydroxylase genes.
POLIOMYELITIS AND POLIOMYELITIS-LIKE VIRUSES OF MAN AND ANIMALS (1951)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More
VIBRATION OF TALL BUILDIND DUE TO STRONG EARTHQUAKE : Part 1, Numerical Analysis Method on Response of Building (1964)

Authors studied a method of response analysis on the tall buildings, whose structure are space frame, due to strong earthquake by using electric digital computer, and completed the programing of this problem for computer. They checked on the accuracy of this numerical analysis and obtained the conclusion as follows; I) About the time interval of one step of calculation, that is computed by method of step by step, ⊿T=0.01 see. is adequate. II) The accuracy of the time of earthquake accelerogram is effective to the result of this response analysis on the building.
EVIDENCE OF MAIZE (ZEAMAYS L.) EXPLOITATION AROUND AN ANCIENT CROSSROAD LINKING DIFFERENT ABORIGINAL AMERICAN CIVILIZATIONS (2014)

A historic net of pathways referred to as Peabiru was constructed connecting the southern of Brazil with the Peruvian Andes. The path disappeared during the Colombian era but was an important testimony of the Brazilian preColombian epoch. To understand the human migrations during the preColombian around Peabiru we examined the genetic relationship of modern landraces and archaeological maize considering the ADH2 gene.Peabiru sequences were grouped with archaeological Andine specimens suggesting an early exploitation of maize around this historic path, involving preColombian Andian people and Guarany natives, and endorsing the debate regarding the presence preColombian human populations nearby the transition area around BrazilParaguay border.
Inversion of Electrical Logging by Newton-SVD with Stochastic Particle Swarm (2010)

We propose a method to invert two parameters(virgin zone resistivity,invaded zone) of dual lateral logging which is based on Newton-SVD of particle swarm.Reasonable initial values are selected by random particle swarm method.Newton-SVD is applied to invert dual lateral logging data.It improves stability and reliability of logging inversion greatly,and offers a radical way for setting initial values of inversion.Ideal model with noise and practical logging data are compared.It shows that the method eliminates effects of complex logging environments effectively and offer true formation parameters.
Energy conservation via heat transfer enhancement. Quarterly progress report, October 1-December 31, 1979 (1979)

Contacts with researchers, manufacturers, and users of enhanced heat transfer equipment are summarized. The Technical Literature file and the Patent File continue to be updated; the Patent File is the source for a patent technology report now in draft form. Application studies on a rationally-based friction correlation for internally-finned tubes and on the evaluation of candidate tube-side enhancements for OTEC applications are reported. The technology study on enhancement of spray evaporation is also discussed.
Corticosterone induces DNA methyltransferases expression in rat cortical neurons (2015)

SpringerPlus 2015, 4(Suppl 1):L1 MicroRNAs (miRNAs) are short, 22-25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3'-untranslated region (3'-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3'-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found that brain miRNAs co-evolved with their target transcripts, that non-coding pseudogenes with miRNA recognition elements compete with brain coding mRNAs on their miRNA interactions, and that Single Nucleotide Polymorphisms (SNPs) on such pseudogenes are enriched in mental diseases including autism and schizophrenia, but not Alzheimer's disease (AD). Focusing on evolutionarily conserved and primate-specifi c miRNA controllers of cholinergic signaling ('CholinomiRs'), we fi nd modifi ed CholinomiR levels in the brain and/or nucleated blood cells of patients with AD and Parkinson's disease, with treatment-related diff erences in their levels and prominent impact on the cognitive and anti-infl ammatory consequences of cholinergic signals. Examples include the acetylcholinesterase (AChE)-targeted evolutionarily conserved miR-132, whose levels decline drastically in the AD brain. Furthermore, we found that interruption of AChE mRNA's interaction with the primatespecifi c CholinomiR-608 in carriers of a SNP in the AChE's miR-608 binding site induces domino-like eff ects that reduce the levels of many other miR-608 targets. Young, healthy carriers of this SNP express 40% higher brain AChE activity than others, potentially aff ecting the responsiveness to AD's anti-AChE therapeutics, and show elevated trait anxiety, infl ammation and hypertension. Non-coding regions aff ecting miRNA-target interactions in neurodegenerative brains thus merit special attention.
TEM study of pressure-induced C<sub>60</sub>transformation into ill-ordered graphite phase (2011)

to their extended porosity and chemical and structural versatility.
Color Constancy by Local Averaging (2007)

As the color of an object partly depends on the color of the illumination, computer vision systems that rely on color features are likely to benefit from a property that most humans have naturally: color constancy. Color constancy is the ability to recognize colors of objects, invariant to the color of the light source. In this paper, an new algorithm is proposed based on local averaging, which is tested on a publicly available data set. The proposed method is shown to be at least competitive to current state-of-the-art methods, however, at lower computational costs.
A Model of Pad–Abrasive Interactions in Chemical Mechanical Polishing (2007)

In model descriptions of CMP, slurry abrasives stick to and release from the polishing pad. This model extension predicts how pad–abrasive interactions depend on abrasive size. The prediction is compared to five sets of experimental data for systems using silica or alumina abrasives and different pads to polish copper, tungsten, or tantalum under various experimental conditions. The finding that larger particles are harder to dislodge from the pad than smaller ones holds over two orders of magnitude in abrasive diameter. This affects material removal rates which depend on the number of abrasive particles attached to the pad.
Prolonged aortic cross-clamping in early infancy and method of myocardial preservation. (1988)

A cardioplegic solution containing blood with a low level of ionic calcium was prepared independent of pump-oxygenator perfusate blood, so as to contain a constant concentration of each component at any given time. Using this solution, Jatene's anatomic repair under prolonged periods of aortic cross-clamping ranging from 117 to 184 minutes (mean: 149 min) was performed on seven young infants with simple complete transposition. The ages of the patients ranged from 34 days to 3 months, with a median age of 2 months. Four patients, aged 39 days, 41 days, 2 months and 3 months, survived and showed uneventful postoperative hemodynamics. Two of the three non-survivors were considered retrospectively to have been unsuitable candidates for Jatene's anatomic repair due to their low left ventricular pressure (LV/RV pressure ratio less than 0.60 in both). The remaining infant who died had TGA with a large ventricular septal defect of the muscular type and developed a postoperative residual shunt. It was considered unreasonable to attribute the cause of death in this case to inadequate myocardial protection. Judging from our experience with these four survivors who underwent prolonged aortic clamping ranging from 117 to 160 minutes, our cardioplegic solution and the technique of its administration were considered to be effective and promising for heart surgery in young infants and neonates.
Biological control of<i>Ostertagia ostertagi</i>by feeding selected nematode-trapping fungi to calves (1993)

Abstract Three nematode-trapping fungi, one Arthrobotrys oligospora and two Duddingtonia flagrans isolates, were fed to Ostertagia ostertagi -infected calves to test their ability to destroy larvae of this parasite in faeces and consequently to reduce the transmission of infective larvae to herbage. The fungi had previously been selected for their capability to pass the alimentary tract of cattle without losing growth and nematode-trapping potentials. Dung was collected from three calves each fed one of the three fungi and placed as 1-kg cow pats on a parasite-free grass plot together with control cow pats from a calf that was not given fungi. The cow pats contained comparable concentrations of parasite eggs. The two D. flagrans isolates were highly effective in that they reduced herbage larval infectivity by 74–85%. In contrast, A. oligospora did not show any effect in the present experiment. Field experiments will demonstrate if D. flagrans represents a potential organism for biological control of bovine gastrointestinal nematodes under practical agricultural management conditions.
Biophysics of hemoglobin (1986)

The major goal of time-resolved absorption and Raman spectroscopy on photodissociated ligand hemoglobin has been to provide a detailed description of the events occurring after dissociation of the ligand and to relate these events to the mechanism through which the protein controls the iron—ligand dissociation and binding properties. We report transient absorption spectra in the Soret band and Raman spectra measured at room temperature for human hemoglobin, myoglobin, and α or β subunits in the femtosecond and picosecond domain following photodissociation of the CO, O2, or NO ligand complex with 120 fs or picosecond laser pulses.
Enhanced Antitumor Efficacy of Adriamycin in Combination with Interferon-γ: Effects on Macrophages (1988)

The combination of the immunomodulator interferon-gamma (IFN-gamma) with the chemotherapeutic drug adriamycin (ADM) was assessed in vitro and in vivo in murine tumor models. When tested in vivo against the murine Lewis lung carcinoma, significantly greater reduction of spontaneous pulmonary metastases was obtained by combination treatment with IFN-gamma, followed 1 day later by ADM. Intraperitoneal ADM treatment also resulted in an increased recruitment of peritoneal mononuclear cells. It is noteworthy that, although the antitumor efficacy was significantly increased by the IFN-gamma/ADM combination treatment, gross toxicity of ADM was not increased. Thus, a net increase in the therapeutic index of ADM was achieved. In vitro, the effects of ADM on the ability of murine peritoneal macrophages, with or without the addition of immunological macrophage activators, to kill tumor cells was studied. Resident macrophages were able to sequester ADM (when present at 10 micrograms/ml) from the medium, and could subsequently mediate killing of target tumor cells. However, incubation of macrophages with low (ineffective by themselves) doses of ADM (1 microgram/ml) prevented their simultaneous or subsequent activation to the tumoricidal state after incubation with the normal macrophage-activating mixture of IFN-gamma plus a muramyl dipeptide (MDP) analog. When the order of addition of reagents was reversed such that the macrophages were preincubated for 24 hr with IFN-gamma (100 U/ml) plus the MDP analog (0.1-10 micrograms/ml), no antagonism of tumoricidal activity was obtained upon subsequent incubation with ADM. There were no interactions between IFN-gamma and ADM on the direct proliferation of tumor cells. Taken together, these results suggest that the enhanced antitumor efficacy of IFN-gamma/ADM combinations in vivo was not due to direct antiproliferative effects on the tumor cells, but rather may be mediated by direct cytotoxicity of ADM on tumor cells enhanced by phagocytic mononuclear cells.
<title>Biosensor systems for pesticide determination in water</title> (1993)

Different biosensor systems suitable for the determination of pesticides in water are described. They are based on immobilized biological components, which are sensitive to compounds commonly used as pesticides. The biological components in the work described here were microorganisms capable of degrading chlorinated aromatic compounds, cholinesterases which are inhibited by carbamates and organophosphates, and antibodies specific to triazines. They were immobilized on various carriers and were either integrated in automated flow-through systems or developed as disposable electrodes. In this contribution, characteristics features of the different formats are given, e.g., the dependence of the specificity and sensitivity of the system on the biological component.© (1993) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Dynamic assignment of random access code channels (2002)

In this paper, a measurement-based dynamic RA (Random Access) code assignment procedure Is proposed for prioritized packet data transmission in WCDMA (Wideband Code Division Multiple Access) networks. This dynamic assignment process is based on analytical performance results derived for random packet access under Rayleigh fading in WCDMA networks. The performance of the proposed measurement-based RA code assignment procedure with three different adaptation methods is evaluated using computer simulation for bursty data packet arrival patterns. The performance of the proposed scheme is compared to those of a retransmission control-based and static channel allocation-based prioritized packet access schemes. The proposed scheme can be used in an adaptive QoS (Quality of Service) framework for dynamically adjusting the QoS of prioritized random access data traffic In the evolving WCDMA-based DS (Differentiated Services) wireless IP (Internet Protocol) networks.
Energy-efficient code generation for DSP56000 family (2000)

This paper presents a procedure to generate energy-efficient code for the Motorola DSP56K processor based on increasing the packing efficiency and minimizing the number of address instructions. The key features are a novel scheduling algorithm that reduces the dependencies between instructions, a register allocation algorithm that spills variables based on their packability, and an address code generation algorithm that minimizes the number of additional instructions. The size of the code generated by this procedure is on the average 45% (25%) smaller than that generated by Motorola's g56 K (SPAM).
A Device and Resource Execution Model for IEC 61499 Control Devices (2007)

The standard IEC 61499 claims to be a standard for a distributed control environment consisting of a set of heterogeneous control devices from different vendors. Previous research work on the implementation of IEC 61499 pointed out so-called loopholes in the definitions of the standard resulting in different execution behaviour on different control devices. One of the key loopholes that have been identified is the lack of a definition for execution models of the device and the resource. With this work a step towards a more rigid definition of the execution semantics for IEC 61499 through the derivation of execution models for resources and devices.
Potentiation of Progesterone Receptor-Mediated Transcription by the Immunosuppressant FK506 (1994)

The nontransformed steroid receptors contain several non-steroid binding proteins, such as hsp90, hsp70, and p59. Recently, we and others have shown that p59 (FKBP59) is an immunophilin which binds two potent immunosuppressants, FK506 and rapamycin. This raises the possibility that FK506 or rapamycin may modify the function of steroid receptors. To develop this line of inquiry, we chose a yeast model system in which the human progesterone receptor form B (hPR-B) was cotransformed with a reporter gene. The reporter contains two copies of a progesterone response element/glucocorticoid response element (PRE/GRE) upstream of the CYC1 promoter which are linked to the lacZ gene of Escherichia coli. We found that FK506 potentiated the ability of progesterone in activating transcription. To gain insight into the mechanism of FK506's regulation of PR action, we questioned whether calcineurin is involved, because it has been shown that FK506 is a specific inhibitor of calcineurin, a Ca(2+)- and calmodulin-regulated phosphatase, through the formation of an FKBP12-FK506-calcineurin-calmodulin complex. We found that 15-O-desmethyl-FK520, an FK506 analogue which is an excellent ligand of FKBP12, but a poor inhibitor of calcineurin, failed to induce the same effect as FK506. We also found that calmidazolium, a calmodulin antagonist, mimicked FK506's action. Furthermore, immunoblot analysis showed that both FK506 and calmidazolium potentiated the effect of progesterone in decreasing the mobility of hPR-B upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). This suggests that FK506 and calmidazolium may cooperate with progesterone in increasing the level of hPR-B phosphorylation.(ABSTRACT TRUNCATED AT 250 WORDS)