gebhart/patrepeval huggingface dataset:
Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines (1997)

Dendritic cells (DC) are migratory cells that exhibit complex trafficking properties in vivo. The present study was designed to characterize receptor expression and responsiveness to chemoattractants of human DC obtained from PBMC by culture with granulocyte/macrophage-CSF and IL-13. DC expressed appreciable levels of the CCR1, CCR2, and CCR5 receptors for the CC chemokines and the chemokine receptors CXCR1, CXCR2, and CXCR4. DC increased intracellular free calcium and migrated in response to the CC chemokines MCP-3, MCP-4, RANTES, MIP-1alpha, MIP-1beta, and MIP-5/HCC2 and the CXC chemokine SDF-1. In contrast, the CC chemokines MCP-1 and eotaxin had little or no activity in the concentration range tested (up to 1 microg/ml). IL-8 and Gro-beta (CXC) and lymphotactin (C chemokines) were also inactive. DC did not respond to 5-HETE, whereas platelet-activating factor was an active agonist. Selected chemokines active on DC in terms of migration and calcium fluxes were examined for their capacity to modulate endocytosis and Ag presentation. Under conditions in which TNF-alpha was active, MCP-1, MCP-3, MIP-1alpha, and RANTES did not affect these two responses. Thus, among hemopoietic elements, DC respond to a unique set of CC and CXC chemokines, and their responsiveness is restricted to migration with no effect on Ag capture and presentation. Chemokines may play a role in the trafficking of DC under resting or stimulated conditions. Chemokine receptors expressed in DC are likely to underlie HIV infection of this cell type.
Update On Phase 2 Clinical Trial To Induce Tolerance In Mismatched Living Donor Renal Transplant Recipients (2013)

Nineteen subjects have been enrolled in a phase 2 protocol (FDA IDE 13947) to induce donor-specific tolerance in HLA-mismatched related and unrelated recipients of living donor renal allografts (KTx). The protocol is based upon tolerogenic CD8+/TCR- facilitating cells (FC) and nonmyeloablative conditioning. Recipients are conditioned with fludarabine (30 mg/kg/dose, days -5, -4, -3), cyclophosphamide (50 mg/kg/dose, day -3 and +3), 200 cGy TBI (day -1) followed by KTx (day 0). A G-CSF mobilized peripheral blood mononuclear cell product is apheresed from the donor > 2 weeks prior to the KTx, processed to remove GVHD-producing cells yet retain CD34+ cells and FC (FCRx), and cryopreserved until infusion on day +1 post-KTx. Subjects ranged in age from 18 to 65 years. All were HLA-disparate from their donors, ranging from 5 of 6 matched related to 0 of 6 unrelated. 18 of 19 subjects exhibited engraftment at 1 month; one highly sensitized subject (PRA > 50%) did not engraft. Subjects were discharged on post-operative day 2 and managed as outpatients. Mycophenolate mofetil and tacrolimus-based immunosuppression were administered for 6 months. At 6 months the MMF was discontinued if the protocol biopsy was normal and stable renal function present. Tacrolimus was weaned at month 9 (trough levels 3-6) and discontinued at 1 year if chimerism, normal renal function, and normal kidney biopsy were noted. No subjects have experienced GVHD or engraftment syndrome. Two early subjects who received a suboptimal cell dose and one other highly sensitized subject were only transiently chimeric (< 6 months); all transiently chimeric subjects resumed endogenous hematopoiesis and are maintained on low-dose tacrolimus monotherapy with stable renal function. The protocol was subsequently modified to exclude subjects with a PRA > 20%. One chimeric subject developed viral sepsis at month 3, thrombosed his kidney, and was successfully re-transplanted off study. A second subject developed CNI-induced hemolytic uremic syndrome (HUS) which resulted in graft loss. He is currently off all immunosuppression and his HUS has resolved. The remaining subjects are either off all immunosuppression (n = 9; 1 to 36 months) or are in the process of tapering. None of the chimeric subjects have developed rejection on protocol biopsy while 3 of the 5 who were not durably chimeric had Banff 1A rejection on protocol biopsy. Recurrence of autoimmune disease has occurred in 2 of 4 non-chimeric subjects, but not in any of the durable chimeric subjects. In summary, high levels of durable chimerism and tolerance without GVHD have been achieved in mismatched related and unrelated recipients of living KTx. Disclosures: Tollerud: Regenerex, LLC: Equity Ownership. Ildstad:Regenerex, LLC: Equity Ownership.
Lack of association between elevated serum Lp(a) and local thrombus lysability in patients with peripheral arterial occlusive disease (1999)

Roller, R. E.; Trinker, M.; Schnedl, W. J.; Pilger, E.; Korninger, C. Author Information
<i>Mycobacterium tuberculosis</i>‐associated synthetic mycolates differentially exert immune stimulatory adjuvant activity (2016)

Mycolic acids (MAs) are highly hydrophobic long-chain α-alkyl β-hydroxy fatty acids present in the cell wall of Mycobacterium tuberculosis (Mtb) as a complex mixture of molecules with a common general structure but with variable functional groups in the meromycolate chain. In this study, we addressed the relationship between the MA molecular structure and their contribution to the development of T-cell immune responses. Hereto, we used the model antigen ovalbumin and single synthetic MAs, differing in oxygenation class and cis versus trans proximal cyclopropane configuration, as immune stimulatory agents. Subcutaneous delivery of liposome-formulated MAs with a proximal cis cyclopropane elicited antigen-specific Th1 and cytotoxic T-cell immune responses, whereas intratracheal immunization elicited pulmonary Th17 responses. These immune stimulatory activities depended not only on the cis versus trans proximal cyclopropane configuration but also on the MA oxygenation class. Our study thus shows that both the presence and nature of the functional groups in the meromycolate chain affect the immune stimulatory adjuvant activity of Mtb mycolates and suggests that Mtb bacilli may impact on the host protective immune response by modulating the cis versus trans stereochemistry of its mycolates as well as by altering the oxygenation class of the meromycolate functional group.
Increased Vulnerability to 3‐Nitropropionic Acid in an Animal Model of Huntington's Disease (1998)

There is substantial evidence for both metabolic dysfunction and oxidative damage in Huntington's disease (HD). In the present study, we used in vivo microdialysis to measure the conversion of 4-hydroxybenzoic acid to 3,4-dihydroxybenzoic acid (3,4-DHBA) as a measure of hydroxyl radical production in a transgenic mouse model of HD, as well as in littermate controls. The conversion of 4-hydroxybenzoic acid to 3,4-DHBA was unchanged in the striatum of transgenic HD mice at baseline. Following administration of the mitochondrial toxin 3-nitropropionic acid (3-NP), there were significant increases in 3,4-DHBA generation in both control and transgenic HD mice, and the increases in the transgenic HD mice were significantly greater than those in controls. Furthermore, administration of 3-NP produced significantly larger striatal lesions in transgenic HD mice than in littermate controls. The present results show increased sensitivity to the mitochondrial toxin 3-NP in transgenic HD mice, which suggests metabolic dysfunction in this mouse model of HD.
Immunohistochemical studies on fibrillin in amyloidosis, lichen ruber planus and porphyria (1990)

The pathogenesis of macular amyloidosis and lichen amyloidosis remains unsolved and the primary amyloid fibril protein(s) has not yet been identified. Ultrastructural association of skin amyloid with elastin associated microfibrils has been noted earlier. The presence of fibrillin in conjunction with such microfibrils was recently demonstrated immunohistochemically. The presence of fibrillin immunoreactivity in the amyloid deposits in skin biopsies from 3 patients with macular amyloidosis and 3 patients with lichen amyloidosis was studied, using monoclonal anti-fibrillin antibodies. For comparison, skin specimens were studied from five patients with lichen ruber planus, four patients with erythropoietic protoporphyria and from a patient with myeloma-associated cutaneous amyloidosis. Renal specimens from two cases of the amyloid A type of renal amyloidosis also were investigated. There was no immunostaining either of the keratin bodies in specimens of lichen ruber planus, the cutaneous PAS-positive vascular deposits in patients with erythropoietic protoporphyria, or the amyloid deposits in specimens of systemic amyloidosis and it was faint or absent in amyloid deposits in the specimens from patients with lichen amyloidosis. In contrast, distinct fibrillin immunoreactivity could be demonstrated in amyloid deposits in specimens from patients with macular amyloidosis. It was sometimes absent in deposits located in the upper part of the papillary dermis, close to the dermal epidermal junction zone, while consistently strong in deposits located lower down in the dermis. The results suggest that fibrillin or part of the fibrillin molecule may be present in some of the amyloid deposits in specimens of macular amyloidosis.
Synthesis, Characterization and Electrochemistry of Complexes Derived from [(1),2,3-P2Mo2W15O61]10– and First Transition Metal Ions (2000)

The complexes formed by [(1)-2,3-P2Mo2W15O61]10– with vanadium(IV), manganese(II), cobalt(II), nickel(II), copper(II), and zinc(II) were synthesized. They were characterized by elemental analysis, IR, UV/Vis and 31P NMR spectroscopy. Their electrochemical studies are complemented by those of the previously synthesized iron(III)- and Mo(VI)-substituted complexes. Among the main conclusions from the electrochemistry of all these compounds, it can be pointed out that only the iron(III) and the copper(II) ions within the complexes are reducible in the same potential domain as the molybdenum(VI) moieties. In the case of the iron(III) complex, it has been possible to obtain a reversible overall three-electron process on the first wave of the oxometalate by varying the pH of the solution. In contrast, copper can be deposited from the corresponding complex. Substitution of [(1)-2,3-P2Mo2W15O61]10– with vanadium(IV), manganese(II), iron(III), cobalt(II), nickel(II), copper(II), zinc(II) and molybdenum(VI) gives a series of complexes in which the trimetallic moiety constituting one of the ‘‘caps’’ of the polyoxometalate contains cations different from the remaining tungsten skeleton. The electrochemical properties of these complexes are modulated by this particular constitution.
Development and Evaluation of a Pedestrian Safety Training Program for Elementary School Bus Riders [Final Report] (2007)

The objective of this study was to develop and evaluate a comprehensive pedestrian safety program for elementary (kindergarten through grade 6) school bus riders. Existing materials, crash data and state laws/regulations on school bus pedestrian safety were reviewed, and a list of 113 behaviors to be included in the program was developed. The major behavioral categories were: getting ready for school, walking to/from the bus stop, waiting at the bus stop, crossing to the bus, boarding the bus, riding the bus, exiting/crossing from the bus and evacuating the bus. The resultant program contains materials for teachers, parents and bus drivers. They include separate "Teacher's Guides" for each of the seven grade levels. Incorporated in the program for children are two previously produced NHTSA videos: "Stop and Look with Willy Whistle" and "Walking with Your Eyes" and one newly developed video titled "Willy Whistle Rides the School Bus". A course poster completes the classroom materials. Parent materials include a video titled "School Bus Safety Starts at Home" and a brochure titled "Reminder to Parents...School Bus Safety Starts at Home". Bus driver materials include a video titled "When They're Not on the Bus" and a brochure titled "They're Pedestrians When They're Not on the Bus". Two promotional pieces (a flyer and an 8-page brochure) were prepared to assist NHTSA in marketing the program. All student materials were evaluated in the East Ramapo Central School District, Spring Valley, New York, using a pre-post design with a comparison site. Statistically significant improvements were achieved in critical knowledge and skills as a result of student participation in the program. /Abstract from report summary page/
INVESTIGATING SHEAR TRANSFER ACROSS CRACKS IN HIGH PERFORMANCE STEEL FIBER-REINFORCED CONCRETE (2010)

This paper presents a rational shear transfer model for high-strength steel fiber-reinforced concrete (HSSFRC). The model inherently considers shear transfer across smooth cracks, bridged by stiff steel fibers, and the resulting crack slip. When implemented into a nonlinear FE algorithm, the model is shown to perform well in simulating the response of uniaxially reinforced HSSFRC panels in shear, including load-deformation response and inclination of principal stress-strain fields. It is shown that while steel fibers are effective in limiting crack slip, they may also deteriorate shear transfer capacity.
Time and Space Partitioning the EagleEye Reference Misson (2013)

We discuss experiences gained by porting a Software Validation Facility (SVF) and a satellite Central Software (CSW) to a platform with support for Time and Space Partitioning (TSP). The SVF and CSW are part of the EagleEye Reference mission of the European Space Agency (ESA). As a reference mission, EagleEye is a perfect candidate to evaluate practical aspects of developing satellite CSW for and on TSP platforms. The specific TSP platform we used consists of a simulated LEON3 CPU controlled by the XtratuM separation micro-kernel. On top of this, we run five separate partitions. Each partition runs its own real-time operating system or Ada run-time kernel, which in turn are running the application software of the CSW. We describe issues related to partitioning; inter-partition communication; scheduling; I/O; and fault-detection, isolation, and recovery (FDIR).
Synthesis of chelating bidentate isocyano and cyano ligands and their metal complexes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of chelating bidentate isocyano and cyano ligands and their metal complexesRobert J. Angelici, Michael H. Quick, George A. Kraus, and Daniel T. PlummerCite this: Inorg. Chem. 1982, 21, 6, 2178–2184Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ic00136a009https://doi.org/10.1021/ic00136a009research-articleACS PublicationsRequest reuse permissionsArticle Views299Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Inhibition of Photochemical Processes by a Hydroxyl Group in the Photochemistry of a β,γ‐Unsaturated o‐Hydroxyphenyl 1,2‐Dimethylcyclopent‐2‐enyl Ketone. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hydrazides of Some Pyridazonyl Substituted Acids (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrazides of Some Pyridazonyl Substituted AcidsFreeman H. McMillan, Kenneth A. Kun, Carol B. McMillan, Benjamin S. Schwartz, and John A. KingCite this: J. Am. Chem. Soc. 1956, 78, 2, 407–410Publication Date (Print):January 1, 1956Publication History Published online1 May 2002Published inissue 1 January 1956https://pubs.acs.org/doi/10.1021/ja01583a043https://doi.org/10.1021/ja01583a043research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: High‐Pressure Synthesis of Rhombohedral α‐AgGaO<sub>2</sub> via Direct Solid State Reaction. (2015)

Abstract α‐AgGaO 2 is prepared via hot pressing of Ag 2 O and Ga 2 O 3 (diamond anvil cell, 10 GPa, 600 °C, 2 h).
Space charge limited current effect on photoconductive decay in silicon at high injection levels (2010)

The space charge limited current (SCLC) effect was analyzed on undoped crystalline silicon wafers at high injection levels. Space charge limited currents develop when the electric field from the injected carriers exceeds that of the background doping. This becomes a relevant phenomenon when applied to materials that use undoped wafers such as back-contact solar cells. It may also be applicable to silicon and non-silicon concentrator cells. The SCLC effect may be significant in the epitaxial thin film materials used in space photovoltaics. Our study uses Resonant Coupled Photoconductive Decay (RCPCD) to analyze and view SCLC via photoconductive carrier lifetime measurements. An undoped Si sample was subjected to the high injection of excess carries by using a pulsed laser source. The excess carrier densities were well above background doping, creating an excess carrier density of approximately 3 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">17</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . This is well above the background carrier density of 1.73 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> (measured by Capacitance-Voltage techniques). The SCLC is detected by observing irregularities, such as positive slope of the photoconductive decay curve in the initial, very high injection portion of the process. A theory of SCLC will be developed and data will be presented.
Anode power deposition in an applied-field segmented anode MPD thruster (1994)

Anode heat flux measurements of a water cooled segmented anode applied-field MPD thruster were made to investigate anode heat transfer phenomena. Pure argon and argon-hydrogen mixtures were used as propellants for a variety of thruster currents, propellant mass flow rates, and axial applied magnetic field strengths. The thruster was operated in two modes; with all four segments active, and with two of the segments floating. In addition, thrust and specific impulse were determined for each operating condition. The results show that the heat flux to the anode increases monotonically with axial magnetic field strength and thruster current. Between 50 and 75 percent of the anode heat flux is transported by the current carrying electrons. Convective and radiative heat transfer account for the remaining portion of the power deposited in the anode. The addition of hydrogen to the argon propellant results in the reduction of the fraction of anode power deposited by the anode fall to a level equivalent to that deposited by convection and radiation.
Support for HLW Direct Feed - Phase 2, VSL-15R3440-1 (2017)

This report describes work performed to develop and test new glass and feed formulations originating from a potential flow-sheet for the direct vitrification of High Level Waste (HLW) with minimal or no pretreatment. In the HLW direct feed option that is under consideration for early operations at the Hanford Tank Waste Treatment and Immobilization Plant (WTP), the pretreatment facility would be bypassed in order to support an earlier start-up of the vitrification facility. For HLW, this would mean that the ultrafiltration and caustic leaching operations that would otherwise have been performed in the pretreatment facility would either not be performed or would be replaced by an interim pretreatment function (in-tank leaching and settling, for example). These changes would likely affect glass formulations and waste loadings and have impacts on the downstream vitrification operations. Modification of the pretreatment process may result in: (i) Higher aluminum contents if caustic leaching is not performed; (ii) Higher chromium contents if oxidative leaching is not performed; (iii) A higher fraction of supernate in the HLW feed resulting from the lower efficiency of in-tank washing; and (iv) A higher water content due to the likely lower effectiveness of in-tank settling compared to ultrafiltration. The HLW direct feed option has also been proposed as a potential route for treating HLW streams that contain the highest concentrations of fast-settling plutoniumcontaining particles, thereby avoiding some of the potential issues associated with such particles in the WTP Pretreatment facility [1]. In response, the work presented herein focuses on the impacts of increased supernate and water content on wastes from one of the candidate source tanks for the direct feed option that is high in plutonium.
Privacy enhancing identity management (2005)

User centric identity management will be necessary to protect user's privacy in an electronic society. However, designing such systems is a complex task, as the expectations of the different parties involved in electronic transactions have to be met. In this work we give an overview on the actual situation in user centric identity management and point out problems encountered there. Especially we present the current state of research and mechanisms useful to protect the user's privacy. Additionally we show security problems that have to be borne in mind while designing such a system and point out possible solutions. Thereby, we concentrate on attacks on linkability and identifiability, and possible protection methods.