gebhart/patrepeval huggingface dataset:
The prognostic value of the HNK-1 (Leu-7) antigen in prostatic cancer--an immunohistochemical study. (1993)

The anti-HNK-1 (Leu-7) monoclonal antibody (MAb) was revealed to be reactive with noncancerous and cancerous prostatic epithelial cells, although this antibody was originally found to be reactive against natural killer cells. However, the prognostic significance of HNK-1 antigen in prostatic cancer patients remains unknown. The expression of HNK-1 antigen on prostatic cancer was investigated immunohistochemically using the avidin-biotin-peroxidase complex (ABC) method with the anti-HNK-1 monoclonal antibody. Of the 52 patients with prostatic cancer, 49 patients (94%) showed reactivity to anti-HNK-1 MAb and the immunoreaction was associated with the histological differentiation of prostatic cancer. Well differentiated cancer showed the highest percentage of positively stained cancer cells and poorly differentiated cancer showed the lowest percentage. No statistically significant differences existed between groups classified by stage, although the more advanced cancers tended to have weaker reactions. The five-year survival rate and interval free of progression were then studied using the Kaplan-Meier method on 33 patients with stage D2 disease who had received endocrine therapy. The findings indicated that a high survival rate and a longer interval free of progression were associated with a higher fraction of positively stained cancer cells. In conclusion, the expression of HNK-1 antigen on prostatic cancer may be a useful prognostic factor in patients with prostatic cancer.
The Use of Speed Sensing for Monitoring the Condition of Military Vehicle Engines (1986)

Measurement of engine torque gives an excellent indication of engine condition. This paper describes the application of instantaneous speed sensing as a means of deriving instantaneous acceleration and torque, and thus providing details of engine performance. Four different methods of analysis are investigated, their relative merits determined and recommendations are made to convert these research techniques into viable, in-service, diagnostic tools.
Neutrophil Chemotactic Activity in Cryptogenic Organizing Pneumonia and the Response to Erythromycin. (1996)

The present study was aimed at elucidating the role of inflammatory cells in the pathogenesis of cryptogenic organizing pneumonia, and the mode of action of erythromycin in inhibiting the progression of the disease. Bronchoalveolar lavage fluid was obtained from 16 patients with cryptogenic organizing pneumonia and 4 control subjects. Neutrophil chemotactic activity was determined in relation to the concentration of two cytokines, interleukin-8 and tumor necrosis factor-alpha. Eight patients with cryptogenic organizing pneumonia, 4 with bronchoalveolar lavage fluid neutrophilia and 4 without, received low dose oral erythromycin daily (600 mg) for 2 to 3 months. Bronchoalveolar lavage fluid was obtained before and after treatment. In the bronchoalveolar lavage fluid of cryptogenic organizing pneumonia patients with bronchoalveolar lavage fluid neutrophilia, the levels of neutrophil chemotactic activity, interleukin-8, and tumor necrosis factor-alpha were significantly increased compared with levels measured in control subjects and in cryptogenic organizing pneumonia patients without bronchoalveolar lavage fluid neutrophilia. The level of interleukin-8 correlated with the percent of neutrophils and neutrophil chemotactic activity of bronchoalveolar lavage fluid, while the level of tumor necrosis factor-alpha did not. Furthermore, the levels of interleukin-8 and neutrophil chemotactic activity in the bronchoalveolar lavage fluid of cryptogenic organizing pneumonia patients with bronchoalveolar lavage fluid neutrophilia were significantly decreased following treatment with erythromycin. In contrast, the level of tumor necrosis factor-alpha was not affected by treatment with erythromycin. It is possible that cryptogenic organizing pneumonia is caused by neutrophil-mediated inflammation, and that the favorable clinical effect of erythromycin is due to inhibition of neutrophil accumulation in the peripheral airways through a biological activity other than bacteriostasis, e.g., local suppression of interleukin-8 production.
Historia social y científica de la técnica : Ciencia, Tecnología y Sociedad (1998)

Esta entrega forma parte de tres trabajos; los otros dos desarrollan la parte conceptual y analisis de casos, respectivamente
Phytobilin biosynthesis: cloning and expression of a gene encoding soluble ferredoxin‐dependent heme oxygenase from <i>Synechocystis</i> sp. PCC 6803 (1998)

The phytobilin chromophores of phycobiliproteins and phytochromes are biosynthesized from heme in a pathway that begins with the opening of the tetrapyrrole macrocycle of protoheme to form biliverdin IX alpha, in a reaction catalyzed by heme oxygenase. A gene containing an open reading frame with a predicted polypeptide that has a sequence similar to that of a conserved region of animal microsomal heme oxygenases was identified in the published genomic sequence of Synechocystis sp. PCC 6803. This gene, named ho1, was cloned and expressed in Escherichia coli under the control of the lacZ promoter. Cells expressing the gene became green colored due to the accumulation of biliverdin IX alpha. The size of the expressed protein was equal to the predicted size of the Synechocystis gene product, named HO1. Heme oxygenase activity was assayed in incubations containing extract of transformed E. coli cells. Incubations containing extract of induced cells, but not those containing extract of uninduced cells, had ferredoxin-dependent heme oxygenase activity. With mesoheme as the substrate, the reaction product was identified as mesobiliverdin IX alpha by spectrophotometry and reverse-phase HPLC. Heme oxygenase activity was not sedimented by centrifugation at 100, 000 g. Expression of HO1 increased several-fold during incubation of the cells for 72 h in iron-deficient medium.
Structural Damage Assessment Using Vibration Modal Analysis (2004)

Vibration techniques have been employed for detecting the presence and monitoring the progression of damage in structures. Pinpointing the location of damage is a more complicated and elaborate task. This paper presents modal analysis techniques for locating damage in a wooden wall structure by evaluating damage-sensitive parameters such as resonant pole shifts and mode shapes, residue and stiffness changes. Artificial damage (simulating termite degradation) was created in one of the walls of a specially constructed room. The wall was excited using an impact hammer and its frequency response measured using a laser vibrometer. Resonant poles (plotted in the s-plane) were used for identifying modes that are sensitive to damage, since not all modes are equally affected by the presence of damage. The damaged region was identified by visual comparison of the deformation mode shapes before and after damage. The modal residue and stiffness changes were also quantified for a better representation of the damage location.
PREPARATION OF METHYL ISOPROPENYL KETONE FROM METHYL ETHYL KETONE AND FORMALDEHYDE (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPREPARATION OF METHYL ISOPROPENYL KETONE FROM METHYL ETHYL KETONE AND FORMALDEHYDEEDWARD F. LANDAU and ERNEST P. IRANYCite this: J. Org. Chem. 1947, 12, 3, 422–425Publication Date (Print):May 1, 1947Publication History Published online1 May 2002Published inissue 1 May 1947https://pubs.acs.org/doi/10.1021/jo01167a008https://doi.org/10.1021/jo01167a008research-articleACS PublicationsRequest reuse permissionsArticle Views382Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reinforcement Learning with Long Short-Term Memory (2001)

This paper presents reinforcement learning with a Long ShortTerm Memory recurrent neural network: RL-LSTM. Model-free RL-LSTM using Advantage### learning and directed exploration can solve non-Markovian tasks with long-term dependencies between relevantevents. This is demonstrated in a T-maze task, as well as in a di#cult variation of the pole balancing task. 1
The toxicology of cocoa and methylxanthines: A review of the literature (1982)

The critical review of the literature cited on pharmacology, toxicology, metabolism, and safety assessment clearly demonstrates that cocoa per se has not attracted a great deal of scientific interest because of its long-term usage with no reported adverse effects that would be injurious to man. On the other hand, a great deal of research has been directed towards understanding the pharmacological properties of the methylxanthines--caffeine, theobromine, and theophylline. Much of the emphasis on metabolism, toxicology, teratogenic potential, and safety assessment has been on the evaluation of caffeine. In light of the serious health concerns ascribed to the effects of caffeine and the lack of basic information on theobromine and theophylline, it is imperative that a major research program be undertaken to evaluate these methylxanthines and, of course, cocoa, coffee, and tea. It only will be through elucidating their mechanism of action that we will be in a position to assess their safety. Before committing research efforts to evaluating the long-term effects of these methylxanthines and their respective foodstuffs, which serve as our primary source of exposure, it is critical to initiate more basic research on the metabolism of caffeine, theophylline, and theobromine in several animal species and man. While published reports do appear in this area, it is essential to understand fully the similarities and differences between various animals and man. The influence of dietary factors and drug interactions must also be determined. Before establishing dosage levels for a chronic toxicity study, the pharmacokinetics of the dose must be determined in the species that will be used in long-term studies. This is necessary if there is a dose-dependency in the animal above which saturation may occur and the plasma half-life kinetics change, or shifts occur either in the metabolic pathways of degradation and/or in the route of excretion from the body. The area of teratology must also be thoroughly evaluated. Studies undertaken should include identification and quantitation of the metabolites of caffeine, theophylline, and theobromine in the pregnant animal, the respective pharmacokinetics of each compound, dose-dependency (if this is the case), and their potential teratogenicity. In addition, the influence of other drugs or dietary variables must be included. In addition to teratology, a great deal of research is needed to assess and quantitate fetal and neonatal metabolism of these compounds.(ABSTRACT TRUNCATED AT 400 WORDS)
Plagiarism Detection Using Graph-Based Representation (2010)

Plagiarism of material from the Internet is a widespread and growing problem. Several methods used to detect the plagiarism and similarity between the source document and suspected documents such as fingerprint based on character or n-gram. In this paper, we discussed a new method to detect the plagiarism based on graph representation; however, Preprocessing for each document is required such as breaking down the document into its constituent sentences. Segmentation of each sentence into separated terms and stop word removal. We build the graph by grouping each sentence terms in one node, the resulted nodes are connected to each other based on order of sentence within the document, all nodes in graph are also connected to top level node "Topic Signature". Topic signature node is formed by extracting the concepts of each sentence terms and grouping them in such node. The main advantage of the proposed method is the topic signature which is main entry for the graph is used as quick guide to the relevant nodes. which should be considered for the comparison between source documents and suspected one. We believe the proposed method can achieve a good performance in terms of effectiveness and efficiency.
JAKET: Joint Pre-training of Knowledge Graph and Language Understanding (2022)

Knowledge graphs (KGs) contain rich information about world knowledge, entities, and relations. Thus, they can be great supplements to existing pre-trained language models. However, it remains a challenge to efficiently integrate information from KG into language modeling. And the understanding of a knowledge graph requires related context. We propose a novel joint pre-training framework, JAKET, to model both the knowledge graph and language. The knowledge module and language module provide essential information to mutually assist each other: the knowledge module produces embeddings for entities in text while the language module generates context-aware initial embeddings for entities and relations in the graph. Our design enables the pre-trained model to easily adapt to unseen knowledge graphs in new domains. Experiment results on several knowledge-aware NLP tasks show that our proposed framework achieves superior performance by effectively leveraging knowledge in language understanding.
Enhancement of Photoelectrochemical Hydrogen Production from Hematite Thin Films by the Introduction of Ti and Si (2007)

Doped and undoped hematite (α-Fe2O3) thin film electrodes for photoelectrochemical hydrogen production have been prepared using reactive magnetron sputtering. We present an extensive characterization of the photoelectrochemical, structural, electrical, and optical properties of the α-Fe2O3 films to assess the mechanisms by which the dopants influence photoelectrode performance. The Si-doped and Ti-doped α-Fe2O3 exhibited much higher photoelectrochemical activity than the undoped material. The Ti-doped α-Fe2O3 showed the largest photocurrent as well as the lowest onset potential, the highest electrical conductivity, the lowest activation energy, and the highest charge carrier density. The crystallographic orientation of the films does not appear to be a dominant factor affecting the photocurrent. The changes in conductivity with doping are insufficient to explain the observed changes in the photoelectrochemical activity. The proposed mechanism for the enhanced photocurrent is reduction of recombination due to an improvement of the charge-transfer rate coefficient at the surface and also possibly passivation of the grain boundaries by the dopants. A highly disordered surface and higher grain boundary recombination due to small crystals may explain the lower photocurrent of the Si-doped α-Fe2O3 compared to the Ti-doped material.
Souring of Reservoirs by Bacterial Activity During Seawater Waterflooding (2005)

Abstract Waterflooding with seawater for pressure support is to be employed in many of the deepwater Gulf of Mexico fields. Seawater flooding has been employed in the North Sea oilfields for over thirty years and, therefore, this region serves as a valuable source of case histories of the problems that can be encountered. It is now accepted that due to inadequate control of sulfate-reducing bacteria (SRB) the majority of the North Sea seawater floods resulted in souring of the reservoir. In some cases, hydrogen sulfide concentrations in the production wells have risen to the point where either the well has had to be shut-in or sulfide scavenging chemicals have had to be applied in order to prevent excessive corrosion. Where souring was not predicted, some production systems have had to be upgraded for sour service materials. These remedial actions have resulted in very significant unplanned costs. Although there is no formal published economic data, it is clear that over the history of the North Sea, the cost of lost production and remedial action has been $ 100's millions. This paper reviews the North Sea experience and discusses the models developed in an attempt to predict reservoir souring. The paper discusses the application of chemical biocides attempted to kill the SRB; the injection of nitrate to stimulate other bacterial populations to compete with the SRB for essential nutrients; and the potential for sulfate removal technologies to reduce sulfate and minimise sulfide production. A strategy for the development of future models to help predict and avoid reservoir souring in future seawater floods is also discussed.
Dramatis Personae: Lady Gregory (1962)

Soon after the installation in Woburn Buildings Yeats brought Arthur Symons on a trip to Ireland. They went first to Sligo, lodging with people called Siberry1 on the slopes of Ben Bulben near the Glencar waterfall. It was Symons’ first visit to Ireland, and he sent an enchanting account to The Savoy of days of soft rain mixed with sunshine on Ben Bulben and of Rosses Point with its “seafaring men who know more of the coasts of Spain and of the Barbadoes than of the other side of their mountains “. Symons was charmed by George Pollexfen, and expressed the opinion that the astrologer might in more favourable circumstances have developed an excellent taste for literature. The fortnight in Sligo was followed by a long stay, diversified by a visit to the Aran islands, at Tulira Castle with Edward Martyn, a new friend met in London through Symons’ friend, George Moore.2 This was Yeats’ first sight of that country of limestone rock, storm-beaten trees and old towers, which lies between Galway Bay and the Clare hills, and is the landscape of so much of his later poetry. George Moore was expected to join Martyn’s house party, and presently arrived.
The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis. (2016)

Multiple sclerosis is a complex disease with many different immune cells involved in its pathogenesis. Newly identified T helper cell 22 (Th22) is a subset of CD4(+) T cells with specific properties apart from other known CD4(+) T cell subsets with distinguished function and gene expression. Th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (IL)-22, IL-13, and tumor necrosis factor-α (TNF- α). The frequency of Th22 and related cytokine IL-22 are increased in various autoimmune diseases. Recently, several studies have reported the changes in frequency and function of Th22 in multiple sclerosis. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of multiple sclerosis disease.
Effect of Wheat Bran Particle Size on Dough Rheological Properties (1997)

Commercial hard red spring, hard red winter, soft white and durum wheat brans were used to investigate the effect of wheat bran particle size on the rheological properties of doughs. Wheat brans were first coarsely ground and passed through a bran finisher to remove additional endosperm and aleurone layers. These processes increased total dietary fibre content and decreased starch content of the wheat bran samples. Three particle size distributions, for each wheat bran class, were obtained by further grinding (not by sifting) of the bran samples by different experimental mills. Coarse bran can retain significantly more water than medium or fine bran as measured by a centrifuge method, but bran particle size had no significant effect on dough water absorption. Addition of wheat bran into bread dough systems increased dough water absorption rate, reduced mixing time and decreased dough mixing tolerance as measured by farinograph. Fine particle size wheat bran decreased dough mixing tolerance and reduced mixing time compared to coarse bran. Dough containing fine particle size bran exhibited more strength than dough containing coarse bran after a 180-min rest period as measured by the extensigraph. © 1997 SCI.
Modular Memory System for RISC-V Based MPSoCs on Xilinx FPGAs (2019)

Current application domains, like mobile robotics, or internet of things require high computational power associated with low energy consumption. Therefore, MPSoCs are widely used as an adequate platform for high performance embedded computation. Recently, the emergence of RISC-V instruction set architecture drives SoC designers to adopt it in the design of MPSoCs as a cost-free, modular processor and suitable to be implemented in different hardware platforms. Furthermore, these characteristics make the RISC-V an interesting candidate for an FPGA soft-core processor. In this paper, we present a modular hybrid memory system for a lightweight RISC-V based MPSoC architecture. The implementation of the hybrid memory consists of a global scratchpad on-chip shared memory for both instruction and data for the purpose of communication and synchronization between the processing elements. In addition to a tightly coupled memory associated with each processing element for low latency memory access for private computation. Moreover, the complete MPSoC architecture is scalable and configurable, in terms of the number of PEs, shared/private memory sizes and the number of memory mapped peripherals. A benchmarking environment is developed to evaluate the performance of the proposed hybrid memory system in terms of memory access latency and memory bandwidth and their impact on the computation time. The complete MPSoC architecture is implemented and tested on a Xilinx Zynq 7000 FPGA device.
Ethanolic Fermentation of Blackstrap Molasses and SugarCane Juice Using Very High Gravity Technology (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEthanolic Fermentation of Blackstrap Molasses and SugarCane Juice Using Very High Gravity TechnologyAlison M. Jones, Kolothumannil C. Thomas, and W. Michael IngledewCite this: J. Agric. Food Chem. 1994, 42, 5, 1242–1246Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://doi.org/10.1021/jf00041a037RIGHTS & PERMISSIONSArticle Views663Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (712 KB) Get e-Alertsclose Get e-Alerts
Early Events in Mammalian Fertilization (1987)

CONTENTS PREFACE 109 INTRODUCTION • 110 CAPACITATION OF SPERM •• 111 THE ACROSOME REACTION...... 111 SITE OF THE ACROSOME REACTION .... ... ... 113 BINDING OF SPERM TO THE ZONA PELLUCIDA ....... 118 NATURE OF THE SPERM RECEPTOR •••• 1 24 NATURE OF THE EGG BINDING PROTEIN 132