gebhart/patrepeval huggingface dataset:
Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells (2001)

An important model system for studying the process leading to productive transcription is provided by the superfamily of nuclear receptors, which are for the most part ligand-controlled transcription factors. Over the past years several 'orphan' nuclear receptors have been isolated for which no ligand has yet been identified. Very little is known about how these 'orphan' receptors regulate transcription. In this study we have analysed the biochemical and transcriptional properties of the neuronally expressed orphan nuclear receptor RORbeta (NR1F2) and compared them with the retinoic acid receptor heterodimer RXRalpha-RARalpha (NR2B1-NR1B1) and Gal-VP16 in vitro. Although RORbeta binds to its DNA-binding sites with comparatively low affinity, it efficiently directs transcription in nuclear extracts derived from a neuronal cell line, Neuro2A, but not in nuclear extracts from non-neuronal HeLa cells. In contrast, RXRalpha-RARalpha and the acidic transcription factor Gal-VP16 support transcription in Neuro2A and HeLa nuclear extracts equally efficiently. These observations point to a different (co)factor requirement for transactivation by members of the NR1 subfamily of nuclear receptors.
Near room temperature continuous wave lasing characteristics of GaInAsP/InP surface emitting laser (1993)

The first near room temperature continuous wave lasing operation of a GaInAsP/InP surface emitting laser has been achieved by employing a buried heterostructure and a novel MgO/Si heatsink mirror. A dramatic reduction of threshold current at room temperature and a circular narrow output beam were demonstrated.
SU‐GG‐I‐32: Optimization of Dose Efficiency in Helical Scan and Image Reconstruction at Dynamically Variable Pitches (2008)

Purpose: To present a cone beam helical image reconstruction algorithm for CT diagnostic imaging at dynamically variable pitches and its optimization in dose efficiency. Method and Materials: The ray‐wise 3D weighted helical cone beam filtered backprojection (CB‐FBP) algorithm is extended to carry out image reconstruction at dynamically variable helical pitch, in which the filtering process is carried out in the cone‐parallel geometry along the tangential direction of the helical source trajectory. Consequently, the filtering paths are straight lines at dynamically invariable pitch, but become curves at dynamically variable helical pitches. In addition, since the pitch variation may be caused by either acceleration or deceleration, the filtering paths can be curves containing inflexions. The FORBILD head and thorax phantoms are utilized to evaluate the performance of the extended algorithm. The dynamical variation range of normalized helical pitch in the evaluation is between 0.5:1 and 1.5, which is quite large from the perspective of clinical applications. Moreover, the optimization in dose efficiency is studied by evaluating the noise characteristics at various transitions of helical pitches. Results: The phantom study shows that, at a wide variation of helical pitches, the extended ray‐wise 3D weighted helical CB‐FBP algorithm can provide a well‐balanced imaging performance over reconstruction accuracy, spatial resolution and noise characteristics, while a large field of view can be maintained. Meanwhile, the noise uniformity of the presented algorithm can be improved by optimizing the ray‐wise 3D weighting parameters with the dynamic variation of helical pitch during the scan. Conclusion: Based on the experimental evaluation, especially its robustness over a large variation range of helical pitches, it is expected that the extended ray‐wise 3D weighted CB‐FBP algorithm can meet the challenges posed by advanced clinical applications, in which helical scanning and image reconstruction at dynamically variable pitches and maintenance of noise characteristics are demanded.
Selective protection of hematopoietic stem cells from chemotherapy (1992)

Intensification of chemotherapy, particularly scheduling, has the potential to eradicate tumor cells. Dose-limiting myelotoxicity can be prevented to varying degrees by the administration of hematopoietic growth factors, particularly granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and interleukin-3. Combinations of growth factors are even more effective in reducing the duration of neutropenia and, to a lesser extent, thrombocytopenia. Autologous bone marrow transplantation and peripheral blood 'stem cell rescue' in combination with cytokine therapy is currently the most effective procedure for combating the adverse consequences of myelo-ablative therapy.
PLANNERS' WORKBENCH: a computer aid to re-planning (1981)

Abstract : This paper reports the current status of a computer aid to re-planning, the PLANNERS' WORKBENCH. Current organizational planning methods support the generation of large, complex configurations of planned activities. However, they do not provide mechanisms for modifying plans in the face of changed assumptions or new environmental conditions. The PLANNERS' WORKBENCH would fill this need by recording the considerations made during plan generation--the plan rationale--and providing facilities for exploiting the rationale during re-planning. (Author)
ASCA Observations of the Sculptor Supercluster (1998)

We present ASCA results of the Sculptor supercluster, a rich supercluster with a redshift of 0.11, near to the south galactic pole. We searched for excess emission associated with the supercluster, and obtained the 3 σ upper limit as 16% of the brightness of the cosmic X-ray background in the 0.8–10 keV band. The X-ray properties of member clusters were analyzed and compared with other clusters. As for temperature-luminosity relation, no difference between the clusters in this supercluster and other clusters could be found. Applying the β model, we estimated the gas mass and the total gravitational mass associated with individual clusters, as well as those of the overall supercluster.
Sub-glass-temperature dynamic processes in amorphous solids: a deuterium and carbon-13 NMR study of poly(phenylene sulfide) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSub-glass-temperature dynamic processes in amorphous solids: a deuterium and carbon-13 NMR study of poly(phenylene sulfide)P. Mark Henrichs, V. A. Nicely, and David R. FagerburgCite this: Macromolecules 1991, 24, 14, 4033–4037Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ma00014a010https://doi.org/10.1021/ma00014a010research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 12990: Dephosphorylation of the Z-Disc Protein Syndecan-4 Activates Pro-Hypertrophic Calcineurin-NFAT Signaling in the Myocardium (2010)

The signaling mechanisms involved in myocardial hypertrophy are poorly understood. We have previously linked syndecan-4, a transmembrane proteoglycan localized to the Z-discs and focal adhesions in cardiomyocytes, to myocardial hypertrophy. Mice lacking syndecan-4 do not develop concentric hypertrophy after aortic banding (AB). Here we demonstrate that syndecan-4 anchors and activates the pro-hypertrophic calcineurin A-Nuclear Factor of Activated T-cells (CnA-NFAT) signaling pathway. In syndecan-4 KO AB, NFATc4 activation and expression of NFAT-target genes BNP and RCAN1–4 were significantly lower than in WT AB. Conversely, overexpression of syndecan-4 in HEK293 cells and treatment of cardiomyocytes with a cell-permeable syndecan-4- derived peptide activated NFATc4. Immunoprecipitations showed increased association between CnA, its co-activator calmodulin and syndecan-4 in AB hearts compared to sham-operated controls. Peptide array experiments showed that CnA binds to the cytoplasmic V-C2 region of syndecan-4 through its autoinhibitory domain. Cell permeable V- or C2-region peptides inactivated or activated NFATc4, respectively, while a C1-derived peptide had no effect, suggesting that syndecan-4 both anchors (V-region) and activates (C2-region) CnA. Moreover, we show that phosphorylation of serine 179 (pS179) is reduced in aortic stenosis patients and in AB murine hearts compared to controls. More CnA was pulled down with non-phosphorylated syndecan-4 than with the phosphorylated form, indicating that reduced pS179 in syndecan-4 is involved in the hypertrophic response. Accordingly, pull-down with pS179 resulted in reduced binding of CnA. Activation of NFATc4 occurred in HEK293 cells transfected with a mutant mimicking minimally phosphorylated S179 (S179A), whereas a mutant mimicking constitutive phosphorylation (S179E) did not. Finally, overexpression of CnA in HEK293 reduces pS179, indicating that CnA regulates its own binding and activation by syndecan-4. Our data indicate that in a pressure-overloaded heart, syndecan-4 activates pro-hypertrophic CnA-NFATc4 signaling, and suggest a crucial role for phosphorylation of syndecan-4 and the syndecan-4-CnA interaction in development of myocardial hypertrophy.
Wheatstone bridge method for electromigration study of solder balls in flip-chip packages (2003)

In this paper, we describe a new approach and a new system developed for EM tests of solder balls in a packaging assembly. The approach was based on the Wheatstone bridge method, which provided significant improvement in the sensitivity for detecting EM damage in solder balls. In the bridge circuit, each of the arms can contain an ensemble of solder balls connected in series and/or in parallel to increase the number of solder balls being tested. Thus the method can be used for EM tests of a large ensemble of solder balls, extending the range of statistical detection of early failures and reducing EM test time. Using this method, EM tests were performed at 165/spl deg/ and 235/spl deg/C on 97Pb-3Sn solder balls in ceramic flip-chip packages. The results yielded an activation energy of 0.85 eV. By extending the test time to 2000 hrs at 165/spl deg/C, all of the test circuits except one showed resistance saturation, suggesting the existence of a threshold jL/sub c/ product. Subjected to a maximum resistance change of about 15 m/spl Omega/, the jL/sub c/ product was estimated to be 110 A-cm for 97Pb-3Sn solders at 165/spl deg/C.
The k-moment method for the narrow band modelling of the radiative properties of nonuniform gaseous media (2008)

International audience
Novel pyrometer using photothermal effect and fiber optics (1990)

A novel pyrometric technique is being developed in Electricite de France (EDF) for measuring the surface temperature of the moving blades of partial load steam turbines. This technique uses the photothermal effect to slightly (temporarily) modify the superficial temperature of the object. Theoretical considerations show that the measurement is proportionnal to successive derivatives of Planck's function. The point is that the measurement is thus made. insensitive to background radiation partially reflected to the detection system by the object itself. Moreover, the short duration of the operation (several microseconds) allows quick moving targets to be measured. We here use the method for monitoring the temperature of the moving blades of partial load steam turbines in EDF nuclear power plants. A rod-shaped probe using fiber optics is being built to take measurements in real conditions. Some laboratory preliminary results show effectiveness and good accuracy of the method. Further studies will permit the extension of this new method to many industrial problems where non-contact temperature measurements in adverse radiative conditions are required.
Putting your best tests forward (2003)

Test case prioritization orders tests so that they help you meet your testing goals earlier during regression testing. Prioritization techniques can, for example, order tests to achieve coverage at the fastest rate possible, exercise features in order of expected frequency of use, or reveal faults as early as possible. We focus on the last goal, which we describe as "increasing a test suite's rate of fault detection" or the speed with which the test suite reveals faults. A faster fault detection rate during regression testing provides earlier feedback on a system under test, supporting earlier strategic decisions about release schedules and letting engineers begin debugging sooner. Also, if testing time is limited or unexpectedly reduced, prioritization increases the chance that testing resources will have been spent as cost effectively as possible in the available time.
Coenzym Q<sub>10</sub>. Ein vitaminähnlicher Stoff für Herz, Nerven und Muskulatur (2006)

Hintergrund: Coenzym Q10 gehÖrt zu den vitaminÄhnlichen Stoffen, den Ubichinonen. Da der KÖrper diese Stoffe selbst herstellen kann, ist ein Mangel an Coenzym Q10 im Organismus sehr unwahrscheinlich. Zielsetzung: Erstellung einer Risiko/Nutzen-Analyse sowie eines systematischen Review fÜr Coenzym Q10-Supplemente. Methoden: Systematische Analyse und Bewertung von Humanstudien (prospektive Doppelblindstudien, epidemiologische und retrospektive Studien, kurzfristige biochemische/hÄmatologische Studien («Surrogate Markers»)) der letzten 10 Jahre aus den gÄngigen elektronischen Datenbanken sowie der Angaben von Standardwerken und publizierten Monographien. Ergebnisse und Schlussfolgerungen: Coenzym Q10 ist Bestandteil mehrerer Atmungskettenenzyme. Der aerobe Stoffwechsel braucht deshalb eine ausreichende Menge Coenzym Q10. Coenzym Q10 wirkt ausserdem als Antioxidans. Coenzym Q10 ist in allen Zellmembranen vorhanden. Die hÖchsten Konzentrationen werden in den inneren Membranen der Mitochondrien gemessen. Die Coenzym Q10-Konzentration in den einzelnen Organen ist abhÄngig von ihrem jeweiligen Energieumsatz. Die hÖchste Coenzym Q10-Konzentration findet sich in Herz und Leber. Verschiedene Nahrungsmittel, vor allem tierische Produkte, sind besonders reich an Coenzym Q10. Der Plasmaspiegel von Coenzym Q10 betrÄgt beim gesunden Menschen im Durchschnitt 1 µmol/l. Mit dem Alter und bei bestimmten Krankheiten (Niereninsuffizienz, Asthma etc.) nehmen die Plasmaspiegel von Coenzym Q10 ab. Daraus lÄsst sich aber kein physiologisch bedeutsamer Mangel bzw. die Notwendigkeit einer Supplementation ableiten. Statine senken die Coenzym Q10-Spiegel. Dies kann mit Supplementen korrigiert werden, der klinische Nutzen ist aber nicht erwiesen. Coenzym Q10-Supplemente sind bei mitochondrialen enzephalomyopathischen Leiden indiziert, zum Beispiel MELAS oder hereditÄrem Diabetes mellitus mit Taubheit. Die Therapie mit Coenzym Q10 bei Herzinsuffizienz, Angina pectoris und Kardiomyopathien kann in Kombination mit der Standardtherapie sinnvoll sein. Vermutlich verlangsamt die Gabe von hoch dosiertem Coenzym Q10 die Progression der Parkinson-Krankheit im Anfangsstadium. Die Wirkung einer Coenzym Q10-Supplementation bei anderen Indikationen, zum Beispiel zur Leistungssteigerung in der Sportmedizin, ist noch ungenÜgend belegt. Bei einer Coenzym Q10-Supplementation betrÄgt die Tagesdosis bis zu 30 mg. Die therapeutische Dosis betrÄgt zwischen 60 und 1200 mg; die Indikation ist anhand der publizierten Studien vom Therapeuten empirisch festzulegen. Die Kombination von Coenzym Q10 mit anderen Antioxidantien scheint sinnvoll.
Volume assessment of various wound attributes models using 3D skin surface imaging (2012)

In medical applications, 3D information of ulcer wounds are very crucial in measuring the volume of the ulcer cavity. Volume measurement is the most significant criterion in ulcer wound assessment as reduction in wound volume is an indicator of wound healing. Treatment efficacy can be improved and healing period can be shorten if changes in wound parameters are being observed regularly and accurately. 3D skin surface imaging technique is used to replace the conventional measuring method which is qualitative and subjective. Optical and laser scanners are used to obtain the surface scanned of the ulcer wound. Two algorithms for solid reconstruction and volume computation are being proposed, namely midpoint projection and convex hull approximation. Seventeen ulcer models with different wound attributes have been used to assess the suitability and reliability of the algorithms. Using ulcer models with known volume, it is found that midpoint projection is suitable for all the wound type whereas convex hull is suitable for all types of wounds except wounds with elevated base.
Material development for Cr resistant SOFC cathodes (2016)

Cr poisoning of perovskitic cathodes is a well-identified reason for long-term performance degradation of solid oxide fuel cells (SOFC). Parameters like temperature, Cr partial pressure and cathode gas humidity have been identified to have a major influence on the degradation process. The interaction of the volatile Cr and the cathode includes chemical and electrochemical reactions resulting in microstructural changes due to Cr deposition or element depletion of the cathode perovskite lattice. For state-of-the-art (La,Sr)(Co,Fe)O3 (LSCF) cathodes Sr-segregation is a wellknown phenomenon leading to an insulating SrCrO4 layer on top of LSCF cathode materials. When using a composite electrode like the established (La,Sr)(Mn)O3 with yttria-stabilized zirconia (LSM/8YSZ) Cr deposition is often found on the triple phase boundary between LSM, 8YSZ and the gas phase. Therefore, SOFCs facilitating LSCF and LSM show quite different degradation behavior. Based on external and internal results from model experiments and stack operation, a practical approach for the material development of Cr tolerant ceramic cathode materials will be presented. Focus lies on the interaction of volatile Cr species and cathode materials with varying compositions including A-site deficiency. The overall aim is to find a balance between Cr resistance, ionic and electronic conductivity and stability at elevated temperatures to ensure an even longer operation time for future SOFCs systems.
Anisotropy of the Γ‐point effective mass and mobility in hexagonal InN (2006)

Abstract We determine the anisotropic electron effective mass and mobility parameters in wurtzite InN thin films with free electron concentration N from 1.8 × 10 17 cm –3 to 9.5 × 10 18 cm –3 using Infrared Magneto‐optic Generalized Ellipsometry. The room‐temperature measurements were carried out with magnetic fields up to 4.5 T. For the Γ‐point we estimate m * ⊥ = 0.047 m 0 and m * ‖ = 0.039 m 0 for polarization perpendicular and parallel to the c ‐axis, respectively. Scattering by impurities or ionized donors may explain the decrease of mobility for polarization parallel to the c ‐axis from 1600 cm 2 /(Vs) to 800 cm 2 /(Vs) with increase in N , where the perpendicular mobility is further decreased, likely caused by additional grain boundary scattering. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Using computational tools for hydraulic design of hydropower plants (1995)

Reported is the adaptation of a manual polysaccharide assay applicable for glycoconjugate vaccines such as Prevenar to an automated liquid handling system (LHS) for improved performance. The anthrone assay is used for carbohydrate concentration determinations and was scaled to the microtiter plate format with appropriate mixing, dispensing, and measuring operations. Adaptation and development of the LHS platform was performed with both dextran polysaccharides of various sizes and pneumococcal serotype 6A polysaccharide (PnPs 6A). A standard plate configuration was programmed such that the LHS diluted both calibration standards and a test sample multiple times with six replicate preparations per dilution. This extent of replication minimized the effect of any single deviation or delivery error that might have occurred. Analysis of the dextran polymers ranging in size from 214 kDa to 3.755 MDa showed that regardless of polymer chain length the hydrolysis was complete, as evident by uniform concentration measurements. No plate positional absorbance bias was observed; of 12 plates analyzed to examine positional bias the largest deviation observed was 0.02% percent relative standard deviation (%RSD). The high purity dextran also afforded the opportunity to assess LHS accuracy; nine replicate analyses of dextran yielded a mean accuracy of 101% recovery. As for precision, a total of 22 unique analyses were performed on a single lot of PnPs 6A, and the resulting variability was 2.5% RSD. This work demonstrated the capability of a LHS to perform the anthrone assay consistently and a reduced assay cycle time for greater laboratory capacity.
Orbital and Configuration Influences on Spacecraft Dynamic Response (1998)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Relaxin and Human Chorionic Gonadotropin Concentrations in Blood Serum during the First Trimester of Normal and Pathological Pregnancy (1988)

Relaxin and human chorionic gonadotropin (HCG) were determined in the blood serum of women during normal and pathological pregnancy in the 1st trimester. In normal pregnancy, the hormones showed similar behavior in their secretion pattern up to the 7th week with continuously increasing concentrations. Thereafter different patterns in their secretion developed. In pathological pregnancy, both relaxin and HCG concentrations were significantly lower than in undisturbed pregnancy, following an almost parallel course without peaks.