gebhart/patrepeval huggingface dataset:
Anti-Cancer Potential of Sesquiterpene Lactones: Bioactivity and Molecular Mechanisms (2005)

Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases. In recent years, the anti-cancer property of various SLs has attracted a great deal of interest and extensive research work has been carried out to characterize the anti-cancer activity, the molecular mechanisms, and the potential chemopreventive and chemotherapeutic application of SLs. In this review, we attempt to summarize the current knowledge of the anti-cancer properties of SLs by focusing on the following important issues. First, we discuss the structure-activity relationship of SLs. All SLs contain a common functional structure, an alpha-methylene-gamma-lactone group, and this important chemical characteristic means that the thiol-reactivity of SLs is an underlying mechanism responsible for their bioactivities. Second, we assess the experimental evidence for the anti-cancer function of SLs obtained from both in vitro cell culture and in vivo animal models. Various SLs have been demonstrated to execute their anti-cancer capability via inhibition of inflammatory responses, prevention of metastasis and induction of apoptosis. Thirdly, we outline the molecular mechanisms involved in the anti-cancer activity of SLs, in particular, the SL-thiols reaction, the effect of SLs on cell signaling pathways such as nuclear transcription factor-kappaB (NF-kappaB) and mitogen-activated protein kinases (MAPK). Finally, we recapitulate some important SLs with regards to their anti-cancer activities and their potential in anti-cancer drug development. Taken together, many SLs are emerging as promising anti-cancer agents with potential applications in both cancer chemotherapy and chemoprevention.
Short Notices (1959)

Journal Article Short Notices Get access E. MILLER E. MILLER St. John's CollegeCambridge Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXXIV, Issue 292, July 1959, Pages 521-a–521, https://doi.org/10.1093/ehr/LXXIV.292.521-a Published: 01 July 1959
Biochemical Alterations from Normal Mucosa to Gastric Cancer by <i>Ex vivo</i> Magnetic Resonance Spectroscopy (2008)

This is the first report of synergic applications of ex vivo HR-MAS MRS and electron microscopy in studying the human gastric mucosa differentiation. This research provides useful information about some molecular steps involved in gastric carcinogenesis. The biochemical data obtained on gastric pathologic tissue could represent the basis for clinical applications of in vivo MRS.
Brightness Improvement of Color LCD Systems Using White Sub-pixel Structure and Fuzzy Mapping Algorithm (2007)

This paper presents three novel color filter structures and a fuzzy mapping algorithm for improving brightness of color LCD systems. On the basis of human vision discrimination, the three color filter structures with white sub-pixels are presented to enhance brightness of conventional stripe, Delta and PenTile color filter architectures without loss of their original color saturation and resolution. A new fuzzy mapping algorithm using RGB sub-pixel data around white sub-pixels is proposed to obtain better image quality. Numerous simulation and experimental results are provided to show the efficacy of the proposed structures and mapping method. The proposed techniques can be expected to be pragmatic and effective in designing color LCD display systems for electronic consumer products, such as notebooks, personal digital assistants, mobile phones and etc.
Nature et culture : quelques remarques sur la bestialisation des hommes et des animaux (1996)

Rivera, Annamaria, Nature and Culture The tendency to naturalize the social world dominates contemporary scientific discourse. This discourse cultivates a conception of nature that can be called "essentialist". In it, nature appears to be given a prescriptive role, and even a moral orientation. It is a conceptual orientation that results from a process of reification. The double process of the anthropomorphism of nature and the naturalization of society is instrumental in perpetuating the prevailing social order and in justifying economic liberalism.
Wavefield separation by 3‐D filtering in crosshole seismic reflection processing (1993)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1993Wavefield separation by 3‐D filtering in crosshole seismic reflection processingAuthors: Peter S. RowbothamNeil R. GoultyPeter S. RowbothamUniversity of Durham, England and Neil R. GoultyUniversity of Durham, Englandhttps://doi.org/10.1190/1.1822465 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822465FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1993ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1993 Pages: 1396 publication data© 1993 Copyright © 1993 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Peter S. Rowbotham and Neil R. Goulty, (1993), "Wavefield separation by 3‐D filtering in crosshole seismic reflection processing," SEG Technical Program Expanded Abstracts : 29-32. https://doi.org/10.1190/1.1822465 Plain-Language Summary PDF DownloadLoading ...
Affinity chromatography for the purification of therapeutic proteins from transgenic maize using immobilized histamine (2008)

Plant molecular pharming is a technology that uses plants as bioreactors to produce recombinant molecules of medical and veterinary importance. In the present study, we evaluated the ability of histamine (HIM), tryptamine (TRM), phenylamine (PHEM) and tyramine (TYRM) coupled to Sepharose CL-4B via a 1,4-butanediol diglycidyl ether spacer to bind and purify human monoclonal anti-HIV antibody 2F5 (mAb 2F5) from spiked maize seed and tobacco leaf extracts. Detailed studies were carried out to determine the factors that affect the chromatographic behaviour of mAb 2F5 and also maize seed and tobacco leaf proteins. All affinity adsorbents showed a reduced capacity to bind and a reduced ability to purify proteins from tobacco extract compared to maize extract. Under optimal conditions, HIM exhibited high selectivity for mAb 2F5 and allowed a high degree of purification (>95% purity) and recovery (>90%) in a single step with salt elution (0.4 M KCl) from spiked maize seed extract. Analysis of the purified antibody fraction by ELISA and Western blot showed that the antibody was fully active and free of degraded variants or modified forms. The efficacy of the system was assessed further using a second therapeutic antibody (human monoclonal anti-HIV antibody mAb 2G12) and a therapeutic enzyme (alpha-chymotrypsin). HIM may find application in the purification of a wide range of biopharmaceuticals from transgenic plants.
Morphodynamics of intertidal dunes: a year-long study at Lifeboat Station Bank, Wells-next-the-Sea, Eastern England (1994)

Abstract Sand is driven clockwise by tidal currents round a diamond-shaped sand shoal in the entrance to the harbour at Wells-next-the-Sea. A population of dune bedforms occupying the ebb-dominated channel on the western side of the shoal was monitored for a year (October 1975 to October 1976) in terms of shape (height, wavelength, superimposed immature dunes), movement and bedform composition. Individual dunes and the population of dunes as a whole changed in response to sediment transport on astronomical tidal scales varying from the semi-diurnal to the equinoctial and in response to seasonal meteorological forcing. Most change occurred during the autumn and winter, when strong winds and gales created surges which, in some cases very significantly, enhanced the sediment transport ue purely to the astronomical tide. Dune height was on average greatest during the winter, when the sea temperature was low, and least during the period of summer warmth. Dune height also varied substantially on a spring-neap tidal scale, an increase in height with the onset of many of the springs being followed by a gradual lowering. Dune wavelength showed little response to the springneap variation of sediment transport, but decreased significantly between winter and summer. Varying degrees of time-lag accompanied all changes in bedform characteristics in response to hydraulic change. Although individual dunes had surprisingly large lifespans and ebb-directed excursions, some change was noted m the composition and statistical attributes of the bedform population as the result of appearances and disappearances. The more vigorous episodes of sediment transport created immature (nascent) dunes, some of which grew large enough to become incorporated as new members into the population of mature forms Internally, the dunes were dominated by ebb-oriented cross-bedding, complicated by a variety of intra-set discontinuities commonly associated with mud drapes Some recorded the smoothing of crests during tidal reversal and others the immobility of the bedform over a number of tidal cycles (occasionally many). Other discontinuities expressed the ‘capture’ of immature dunes by the main bedform within the duration of a single ebb-tide. Because of the frequent perturbation of the (astronomical) tidal sediment transport by meterological events, little order to the horizontal arrangement of discontinuities within the sets was detected in contrast to other reported cases.
The "Created by His Seller" Limitation of Section 9-307(1) of the U.C.C.: A Provision in Need of an Articulated Policy (1984)

2. "We recognize that the result which flows from this construction of the statute may seem unjust. . . .However, this is consistent with the general rule set forth in the Code. . ..Furthermore, our holding is in accord with the decisions rendered in other states ... ."Martin Bros. Implement Co. v. Diepholz, 109 II1.App.3d 283
International Law (2021)

International Law is the definitive and authoritative text on the subject. It has long been established as a leading authority in the field, offering an unbeatable combination of clarity of expression and academic rigour, ensuring understanding and analysis in an engaging and authoritative style. Explaining the leading rules, practice and caselaw, this treatise retains and develops the detailed referencing which encourages and assists the reader in further study. This new edition has been fully updated to reflect recent developments. In particular, it has expanded the treatment of space law and of international economic law, and introduced new sections on cyber operations and cyber warfare, as well as reflecting the Covid-19 crisis. Both clarifying fundamental principles and facilitating additional research, International Law is invaluable for students and for those occupied in private practice, governmental service and international organisations.
Review: Prostate cancer epidemiology (1984)

Prostate cancer is common among men in the United States. Factors of possible importance in the etiology of prostate cancer include diet, primarily implicated by ecologic studies of national, regional, and ethnic variation in rates; endocrine function, implicated by the importance of endocrine function in normal prostatic growth and in the treatment of prostate cancer; genetic susceptibility, supported by familial aggregation; some aspect of sexual behavior, suggested by case-control differences in sexual behavior; and occupational exposure, particularly cadmium exposure. Despite the public health importance of prostate cancer, it has received only moderate epidemiologic study; thus the etiologic importance of these and other possible determinants of prostate cancer risk is uncertain [55].
A descoberta (2007)

<span><em>A descoberta</em> por Elias Mol</span>
[Immunoscintigraphy of malignant melanoma]. (1990)

This work is part of a multicentric European evaluation of the monoclonal antibody 225.28s targeted against malignant melanoma and its metastases. Twenty-eight patients (12 males, 16 females, mean age: 53 yrs), who had initially been treated by resection of the primary tumour, were included in the study. Twenty-three of the 26 metastases more than 1 cm in diameter were visualized by immunoscintigraphy. The sensitivity of the procedure (88%) is limited however by the small size of the lesions and their depth, as well as by background noise caused by circulating antibodies. Immunoscintigraphy enables non-invasive investigation of the whole body and can detect lesions that other conventional complementary explorations fail to identify.
Updates on attention deficit hyperactivity disorder, child abuse and neglect, and sudden infant death syndrome (2003)

Department of Medicine, Children's Hospital, Boston, and Clinical Instructor in Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. Correspondence to Katie Campbell Daley, MD, Department of Pediatrics, Harvard Vanguard Medical Associates, 291 Independence Drive, West Roxbury, MA 02467, USA; e-mail: [email protected]
A High-Performance Lossless Compression Scheme for EEG Signals Using Wavelet Transform and Neural Network Predictors (2012)

Developments of new classes of efficient compression algorithms, software systems, and hardware for data intensive applications in today's digital health care systems provide timely and meaningful solutions in response to exponentially growing patient information data complexity and associated analysis requirements. Of the different 1D medical signals, electroencephalography (EEG) data is of great importance to the neurologist for detecting brain-related disorders. The volume of digitized EEG data generated and preserved for future reference exceeds the capacity of recent developments in digital storage and communication media and hence there is a need for an efficient compression system. This paper presents a new and efficient high performance lossless EEG compression using wavelet transform and neural network predictors. The coefficients generated from the EEG signal by integer wavelet transform are used to train the neural network predictors. The error residues are further encoded using a combinational entropy encoder, Lempel-Ziv-arithmetic encoder. Also a new context-based error modeling is also investigated to improve the compression efficiency. A compression ratio of 2.99 (with compression efficiency of 67%) is achieved with the proposed scheme with less encoding time thereby providing diagnostic reliability for lossless transmission as well as recovery of EEG signals for telemedicine applications.
Sex Difference in Epidermal Growth Factor Receptor Levels in Rat Liver Plasma Membrane* (1988)

The specific binding of [125I]epidermal growth factor [( 125I]EGF) to hepatic microsomal membranes was about 2-fold higher in adult male than in adult female rats. Scatchard analysis of the binding data showed that the sex difference in EGF binding was due to the difference in EGF receptor concentration rather than to a change in receptor affinity. From the developmental study, an apparent sex difference in EGF binding was observed from the pubertal period (4 weeks of age). Castration of adult male rats slightly, but significantly, decreased the EGF receptor level; and moreover, treatment of adult females with testosterone increased it only slightly. On the other hand, castration of neonatal male rats decreased the EGF receptor content almost to the female level. The decreased level of the receptor was completely restored by the combination of neonatal and pubertal treatments with testosterone. Neonatal or pubertal treatment alone of castrated animals had no significant effect on the decreased level of EGF receptors. These effects of testosterone were similarly observed when normal female rats were treated with the steroid. Moreover, hypophysectomy of the rats resulted in the marked decrease in EGF receptors only in the male animals. Treatment of hypophysectomized rats with either testosterone or T3 had no apparent effect on the EGF receptors. The membrane protein, cross-linked with [125I]EGF, had a mol wt of 170,000, and this protein (EGF receptor) was phosphorylated basally or by the addition of EGF. The rate of affinity labeling, or phosphorylation of EGF receptors, was in good agreement with the results of the EGF binding study. These results strongly suggest that the EGF receptor level in rat liver plasma membranes is in part regulated by the hypothalamopituitary unit and that neonatal androgens are essential for this regulation, probably through their effects on the hypothalamus.
Graph OLAP: Towards Online Analytical Processing on Graphs (2008)

OLAP (On-Line Analytical Processing) is an important notion in data analysis. Recently, more and more graph or networked data sources come into being. There exists a similar need to deploy graph analysis from different perspectives and with multiple granularities. However, traditional OLAP technology cannot handle such demands because it does not consider the links among individual data tuples. In this paper, we develop a novel graph OLAP framework, which presents a multi-dimensional and multi-level view over graphs. The contributions of this work are two-fold. First, starting from basic definitions, i.e., what are dimensions and measures in the graph OLAP scenario, we develop a conceptual framework for data cubes on graphs. We also look into different semantics of OLAP operations, and classify the framework into two major subcases: informational OLAP and topological OLAP. Then, with more emphasis on informational OLAP (topological OLAP will be covered in a future study due to the lack of space), we show how a graph cube can be materialized by calculating a special kind of measure called aggregated graph and how to implement it efficiently. This includes both full materialization and partial materialization where constraints are enforced to obtain an iceberg cube. We can see that the aggregated graphs, which depend on the graph properties of underlying networks, are much harder to compute than their traditional OLAP counterparts, due to the increased structural complexity of data. Empirical studies show insightful results on real datasets and demonstrate the efficiency of our proposed optimizations.
Introduction (1996)

Abstract The expansion of education has lead to the establishment of a notion referred to as feminism—the awakening of women's consciousness. This involved how women increasingly felt that they should be portrayed as the equal of man as they had to employ more meaningful participation in society than they had in the past. In spite of how enduring feminist organizations came about only during the late 1860s as part of the republican opposition to the Second Empire, feminism in France can be traced to as early as the Revolution and may be viewed as part of the pre-history and history of the Third Republic. While feminist campaigns have not been given much attention, this book attempts to look into these campaigns that advocated the civil and political rights of women while also focusing on how they played a significant part within their families.
An overview of the PubChem BioAssay resource (2009)

The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental descriptions of assays and biological test results and makes the information freely accessible to the public. A PubChem BioAssay data entry includes an assay description, a summary and detailed test results. Each assay record is linked to the molecular target, whenever possible, and is cross-referenced to other National Center for Biotechnology Information (NCBI) database records. 'Related BioAssays' are identified by examining the assay target relationship and activity profile of commonly tested compounds. A key goal of PubChem BioAssay is to make the biological activity information easily accessible through the NCBI information retrieval system-Entrez, and various web-based PubChem services. An integrated suite of data analysis tools are available to optimize the utility of the chemical structure and biological activity information within PubChem, enabling researchers to aggregate, compare and analyze biological test results contributed by multiple organizations. In this work, we describe the PubChem BioAssay database, including data model, bioassay deposition and utilities that PubChem provides for searching, downloading and analyzing the biological activity information contained therein.
Measuring Alcohol in Blood and Breath for Forensic Purposes - A Historical Review. (1996)

This review concerns important events and trends in the evolution of chemical tests for alcohol intoxication on two continents; Europe and North America. In particular, the pioneer workers in this field and their major contributions to forensic alcohol analysis are emphasized. Quantitative methods for the determination of alcohol in blood, breath, and urine appeared early in the twentieth century and experimental alcohol research had already started in several European countries. The first statutory limits of blood-alcohol concentration (BAC) were introduced in Norway and Sweden during the 1930-1940s where Widmark's micro-diffusion method was approved for forensic purposes. Between 1931-1935 in the U.S., the first instrument (the Drunkometer) was developed for measuring the concentration of alcohol in a person's breath to supplement various clinical signs and symptoms of drunkenness. The breath-alcohol concentration (BrAC) was always translated into the presumed coexisting BAC to furnish corroborative or presumptive evidence of impairment at the wheel. After the Breathalyzer device was developed by Borkenstein around 1953-54, breath-alcohol testing became firmly established for law enforcement purposes in the U.S. and Canada. The classic wet-chemistry methods of blood-alcohol analysis were displaced by enzymatic procedures in the early 1950s and in the 1960s gas chromatographic (GC) methods dominated. Today, headspace GC is the mainstay in forensic science laboratories for the determination of alcohol and other volatile substances in body fluids. The first breath-alcohol devices used in Europe were relatively simple screening tests for alcohol at the roadside and positive results were always followed-up by quantitative analysis of alcohol in blood or urine. The technology of breath-alcohol testing has changed dramatically over the years from chemical oxidation and colorimetric procedures towards physicochemical techniques such as gas chromatography, electrochemical oxidation, and multiple wavelength infrared spectrophotometry. In the early 1980s evidential breath-alcohol instruments were approved for law enforcement purposes in many European countries and threshold limits of BrAC were introduced alongside the existing statutory BAC limits.
LOCAL GOVERNMENT General Provisions: Allow Municipal Governing Authorities to Empower Mayor to Enter Into Contracts on Municipal Corporation's Behalf (1990)

The Act empowers the governing authorities of municipal corporations to authorize the mayor to enter into contracts with public and private entities, involving property or facilities used for criminal justice purposes, on behalf of municipal corporations. Monetary, durational and population, limitations on the exercise of this power are provided.