gebhart/patrepeval huggingface dataset:
A vector, pHisGal, allowing bacterial production of proteins fused to a hexahistidine-tagged Gal4 DNA-binding domain. (1994)

A vector, pHisGal, was constructted that allows isopropyl-beta-D-thiogalactopyranoside (IPTG)-inducible expression of the DNA-binding domain of the yeast transcription factor Gal4 in Escherichia coli. Protein sequences to be tested for transcription regulatory potential in conjunction with the Gal4 DNA-binding domain can be inserted in-frame into a multiple cloning site at the C terminus of Gal4. A hexahistidine sequence fused to the N terminus of Gal4 allows efficient purification of the bacterially produced protein by affinity chromatography on nickel nitrilotriacetic acid (Ni-NTA) columns. Purified Gal4 fusion proteins produced in E. coli showed DNA-binding activity in electrophoretic nobility shift assays and were highly active in cell-free transcription assays from higher eukaryotic cells.
A Special-Purpose Computer for Digital Signal Processing (1975)

This paper describes a special-purpose processor for use in performing various operations on sampled signals. The system is fast, flexible, and programmable for performing, in real time, operations such as fast Fourier transformation (FFT) and digital filtering of acoustically derived signals.
A Combination Therapy of Gemcitabine With Immunotherapy for Patients With Inoperable Locally Advanced Pancreatic Cancer (2009)

This combined therapy was considered to be synergistically effective and may have a role in the therapy of pancreatic cancer for inducing tumor antigen-specific CTLs.
Cloud Storage Management Technology (2009)

The paper concentrates on analyzing and discussing data pooling structure, online data pooling partition storage model, structure model of enterprise cloud storage system, proposes the design plans of data control and cloud storage. Storage management control optimized is an effective method that will reduce the working time to large-scale data storage management. Combining Storage devices and control management software will provide system data sharing and system high applicability. With cloud storage management control mechanism being applied, those business enterprises could benefit from this.
A new approach in the assessment of motor activity in Parkinson's disease. (1991)

Motor activity was recorded continuously with a wrist-worn activity monitor for almost six days in nine patients with different predominant manifestations of Parkinson's disease and 10 normal subjects. The indices of diurnal motor activity decreased with the progressive worsening of hypokinesia and rigidity. With this monitor and a simple diary it was possible to determine the contribution of a moderate resting tremor and choreiform dyskinesias to the motor activity level, and to monitor their variability.
1 Multimedia Proxy Caching Mechanism for Quality Adaptive Streaming Applications in the Internet (1999)

Abstract — The Internet has witnessed a rapid growth in deployment of Web-based streaming applications during recent years. In these applications, server should be able to perform end-to-end congestion control and quality adaptation to match the delivered stream quality to the average bandwidth available. The delivered quality is limited by the bottleneck bandwidth on the path to the client. This paper proposes a proxy caching mechanism for layered-encoded multimedia streams in the Internet to maximize the delivered quality of popular streams to interested clients. The main challenge is to replay a quality-variable cached stream while performing quality adaptation effectively in response to the variations in available bandwidth. We present a pre-fetching mechanism to support higher quality cached streams during subsequent playbacks and improve the quality of the cached stream with its popularity. We exploit inherent properties of multimedia streams to extend the semantics of popularity and capture both level of interest among clients and usefulness of a layer in the cache. We devise a fine-grain replacement algorithm suited for layered-encoded streams. Our simulation results show that the interaction between the replacement algorithm and pre-fetching mechanism converges the state of the cache to an efficient state such that the quality of a cached stream is proportional to its popularity, and the variations in quality of a cached stream are inversely proportional to its popularity. This implies that after serving several requests for a stream, the proxy can effectively hide low bandwidth paths to the original server from interested clients.
Electroclinic behaviour of polymer doped low molar mass ferroelectric liquid crystals (1993)

Abstract Recently there has been much interest in the electroclinic effect due to its potential application in high speed optical modulators and grey scale displays. In present materials, however, the electroclinic effect is very dependent on temperature and falls off rapidly with increasing temperature. This limits the useful device operating range. In this paper the electroclinic behaviour of new, side chain polymer doped, low molar mass ferroelectic liquid crystal mixtures is reported. By measuring the rate of change of the electroclinic coefficient with temperature it is shown that the temperature range over which the electroclinic effect exists increases with polymer concentration. Data are also presented on electroclinic response times.
Professional Sitecore 8 Development (2016)

Front- and back-end developers will utilize this step-by-step guide and comprehensive overview of Sitecore development and best practices to structure templates and content within Sitecore, work with integrated tools, and leverage its extensive automation capabilities. Sitecore was recently recognized as one of the most reputable and reliable, enterprise-class web content management solutions (WCMS) available in the marketplace. Thousands of companies are using Sitecore to manage their digital experiences online. Because Sitecore is such a large, complex platform, developers often have a hard time coming up to speed, even after completing a Sitecore training course for developers. However, leveraging the design patterns and other practices laid out in this book will make that transition much easier. Professional Sitecore 8 Development provides a soup-to-nuts approach for a Sitecore rookie to come up to speed quickly, as well as provide more advanced techniques for seasoned veterans that they may not be exposed to otherwise. Key coverage areas include: Getting started with Sitecore development Front-end development techniques Incorporating design patterns into your Sitecore solutions Unit testing Sitecore applications Programming Sitecoreâs marketing capabilities Sitecore automation with PowerShell Advanced development techniques.
Individual Addressing of Trapped Ions and Coupling of Motional and Spin States Using rf Radiation (2009)

Individual electrodynamically trapped and laser cooled ions are addressed in frequency space using radio-frequency radiation in the presence of a static magnetic field gradient. In addition, an interaction between motional and spin states induced by an rf field is demonstrated employing rf optical double resonance spectroscopy. These are two essential experimental steps towards realizing a novel concept for implementing quantum simulations and quantum computing with trapped ions.
MAlSim - Mobile Agent Malware Simulator (2008)

One of the problems related to the simulation of attacks against critical infrastructures is the lack of adequate tools for the simulation of malicious software (malware). Malware attacks are the most frequent in the Internet and they pose a serious threat against critical networked infrastructures.
[Modern pain therapy in general practice. "Pain is what the patient perceives as pain"]. (2002)

Virtually one person in two is afflicted by pain. In many cases its management, in particular the chronic form, is anything but appropriate to the patient's actual needs. Adequate pain treatment begins with the acceptance of the patient's perception of pain. Pain must be differentiated not only by its cause, nature and intensity, but also by psychosocial factors (unemployment, poverty). Within the framework of a comprehensive communicative interchange between physician and patient, self-medication and explanation models offered by the patient, must be considered. An important task for the general practitioner is to appreciate the "plastic phase" of pain, in which pain memory begins to develop, so as to initiate effective analgesia early on. For this purpose, it is essential that the physician be familiar with the interfaces with specialists, as also with the WHO stepped schema, in particular the indication for powerful stage III analgesics, and with the possible need for accompanying medication.
Components and Services Session Report (2006)

This paper shortly summarises the working session "Components and Services" held at WICSA 2005 (Working International Conference on Software Architecture). Both components and services are strongly related to software architecture and have now an increased focus in research and practitioners’ communities. Both component-based and serviceoriented development, use the same technologies and same or similar principles in architecting of software systems. Still there have not been many interactions between the "components" and "services" communities. For this reason the events like this working session are very important to bring the communities together, to increase the mutual understanding, to exchange experience and to share solutions.
Dual-polarized slot-coupled planar antenna with wide bandwidth (2003)

A new dual-polarized slot-coupled microstrip patch antenna is presented, which can achieve high-isolation, low cross-polarization levels, a wide bandwidth, and low backward radiation levels. The coupling slot is an H-shaped slot. For wide bandwidth and easy integration with active circuits, it uses slot-coupled stacked microstrip patches. The theoretical analysis is based on the finite-difference time-domain (FDTD) method. First, a parametric study on the input impedance of the antenna with a single input port is presented. Based on the results, a dual-polarized microstrip antenna is designed, fabricated, and then measured. The measured return loss exhibits an impedance bandwidth of over 20.9% and the isolation between two polarization ports is better than 36 dB over the bandwidth. The cross-polarization levels in both E and H planes are better than 22 dB. The front-to-back ratio of the antenna radiation pattern is better than 21 dB. Both theoretical and experimental results of return loss, isolation, and radiation patterns are presented and discussed.
The design of a TDMA system for passive optical networks (1990)

The authors describe the design methodology and implementation details of a time-division multiple access (TDMA) system which has been developed to allow point to multipoint operation of passive optical networks. This TDMA bit transport system transparently handles the multiplexing and control functions required for passive splitting optical networks. The system is generic and, with relatively simple interfacing, applicable to switching systems worldwide. The design has been implemented in ASIC (application-specific integrated circuit) technology for a forthcoming UK field trial of fiber in the subscriber loop.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A decision-directed blind equalization with the error variance estimation (2002)

A blind equalization algorithm may be switched to a decision-directed (DD) scheme in order to speed up the convergence rate. In this paper, we propose a new blind equalization scheme that automatically switches to the DD mode. The proposed scheme operates in two mode: blind equalization mode and a DD mode. The mode is determined by the region in which the equalizer output lies, and the region varies as a function of the estimate value of the error variance. Only the equalized signal that falls in the region of confidence is used to calculate the variance. From simulation results, it is shown that this scheme can achieve faster convergence and small MSE.
Extracting Web design knowledge: the Web De-Compiler (2003)

We introduce a Web De-Compiler (WDC) that extracts Web design information for reuse. Given a Web site, the system extracts design knowledge at several levels: site organization and navigation, page layout, and objects. Objects are regular structures within a page including paragraphs, tables and images. Page layout includes the use of color, fonts, background images, and placement of objects. Design information is extracted by analyzing the HTML tags and images of a Web page. An autonomous agent utilizing the WDC is cataloging all of the designs on the Internet. The design information can be reused in automated and semi-automated Web site design, re-design and analysis.
An Approach To Instrument Augmentation : The Electric Guitar (2008)

In this paper we describe an ongoing research on augmented instruments, based on the specific case study of the electric guitar. The key question of the relationship between gesture, instrument and sound is approached via an analysis of the electric guitar’s design, playing technique and interface characteristics. The study points out some inherent defaults in the guitar’s current forms of acoustic-electric hybridation, as well as new perspectives for a better integration of the relationship between instrumental gesture and signal processing. These considerations motivate an augmented guitar project at the CICM, in which a gestural approach to augmentation is developed, emphasising the role of the instrumentist’s repertoire of body movements as a source for new gesture-sound « contact points » in the guitar playing technique.
Super fast and efficient channel equalizer architecture based on neural network (2012)

Broadband wireless communication systems are currently in a rapid evolutionary phase in terms of development of various technologies, development of various applications, deployment of various services and generation of many important standards in the field. Ever increasing demand on various services justifies the need for the transmission of data at the highest possible data rates. The multipath and fading characteristics of the wireless channels result in various impairments and distortions, the most important of those being the Inter-Symbol Interference (ISI) especially at relatively high data rates. Among the various possible solutions to mitigate ISI, the adaptive equalizer remains one of the most attractive solutions, particularly the algorithms requiring minimal or no training sequence and at the same time are computationally efficient. This paper presents a novel neural networks based architecture for channel equalizers that require only order of 20–40 training symbols to converge to the optimum solution and at the same time is computationally efficient.
A Cyclin D-Cdk4 Activity Required for G2 Phase Cell Cycle Progression Is Inhibited in Ultraviolet Radiation-induced G2 Phase Delay (1999)

Cyclin D-Cdk4 complexes have a demonstrated role in G1 phase, regulating the function of the retinoblastoma susceptibility gene product (Rb). Previously, we have shown that following treatment with low doses of UV radiation, cell lines that express wild-type p16 and Cdk4 responded with a G2 phase cell cycle delay. The UV-responsive lines contained elevated levels of p16 post-treatment, and the accumulation of p16 correlated with the G2 delay. Here we report that in UV-irradiated HeLa and A2058 cells, p16 bound Cdk4 and Cdk6 complexes with increased avidity and inhibited a cyclin D3-Cdk4 complex normally activated in late S/early G2 phase. Activation of this complex was correlated with the caffeine-induced release from the UV-induced G2 delay and a decrease in the level of p16 bound to Cdk4. Finally, overexpression of a dominant-negative mutant of Cdk4 blocked cells in G2 phase. These data indicate that the cyclin D3-Cdk4 activity is necessary for cell cycle progression through G2 phase into mitosis and that the increased binding of p16 blocks this activity and G2 phase progression after UV exposure.
An alternative position for the pulse oximeter probe (2001)

We would like to report a simple, effective solution to a persistent problem. As we all know, pulse oximeters can have difficulty picking up a reliable signal, especially in critically ill patients with poor peripheral perfusion. Ear lobe probes sometimes overcome this problem, though in practice they aren't always helpful. However, their reliability is greatly improved by positioning the probe on the nasal septum. A robust signal is nearly always produced even in patients with peripheral vasoconstriction in whom other sites have proved useless. Moreover, the nasal septum is (usually) a readily accessible, stable and protected site. We now use this site routinely in situations where there has been difficulty detecting a signal. We are not aware of this use of ear probes having been previously reported.
Preparation of Pyrenyl-Modified Nucleosides via Suzuki-Miyaura Cross-Coupling Reactions (2002)

The modified nucleosides 5-pyrenyl-2′-deoxyuridine (1) and 8-pyrenyl-2′-deoxyguanosine (2) were synthesized via palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of pyren-1-yl boronic acid (3) to either 5-iodo-2′-deoxyuridine (4), or 8-bromo-2′-deoxyguanosine (7), respectively. No protecting groups for the hydroxy and amino functions of the nucleoside are needed during the preparation. Both pyrene derivatives are suitable nucleoside models for the spectrosopic investigation of reductive electron transfer (in 1), or oxidative hole transfer (in 2).
Challenges and Solutions in Modern VLSI Placement (2007)

The VLSI placement problem is to place objects into a fixed die such that there are no overlaps among objects and some cost metric (e.g., wirelength, routability) is optimized. It is a major step in physical design that has been studied for decades. However, modern VLSI design challenges have reshaped the placement problem. A modern placer needs to handle large-scale designs with millions of objects, heterogeneous objects with very different sizes, and various complex placement constraints such as preplaced blocks and chip density. In this paper, we first introduce the major techniques employed in our placer for tackling the large-scale mixed-size designs and the aforementioned constraints, and then provide some future research directions for the modern placement problem.
Short-term wind speed forecasting with ARIMA model (2014)

The paper deals with the short-term forecasting of wind speed for the Laukžeme wind farm (Lithuania) using time series approach. The ARIMA model was selected and its best structure determined using the historical wind speed data (4 months) and varying both learning interval (3–5 days) of the model and the factual data averaging time (1–6 hours). The accuracy of forecasting was evaluated in terms of RMSE and absolute error. The forecasting results for 39 consecutive time intervals with 6–48 hourly forecasts are presented and discussed.
Comparison of P&O and hill climbing MPPT methods for grid-connected PV converter (2008)

Maximum power point tracking (MPPT) techniques are employed in photovoltaic (PV) systems to make full utilization of the PV array output power which depends on solar irradiation and ambient temperature. Among all the MPPT strategies, perturbation and observation (P&O) and hill climbing methods are widely applied in the MPPT controllers due to their simplicity and easy implementation. In this paper, both P&O and hill climbing methods are adopted to implement a grid-connected PV system. Their performance is evaluated and compared through theoretical analysis and digital simulation. P&O MPPT method exhibits fast dynamic performance and well regulated PV output voltage, which is more suitable than hill climbing method for grid-connected PV system.
Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson’s disease (2018)

Dopamine controls various physiological functions in the brain and periphery by acting on its receptors D1, D2, D3, D4, and D5. Dopamine receptors are G protein-coupled receptors involved in the regulation of motor activity and several neurological disorders such as schizophrenia, bipolar disorder, Parkinson's disease (PD), Alzheimer's disease, and attention-deficit/hyperactivity disorder. Reduction in dopamine content in the nigrostriatal pathway is associated with the development of PD, along with the degeneration of dopaminergic neurons in the substantia nigra region. Dopamine receptors directly regulate neurotransmission of other neurotransmitters, release of cyclic adenosine monophosphate, cell proliferation, and differentiation. Here, we provide an update on recent knowledge about the signalling mechanism, mode of action, and the evidence for the physiological and functional basis of dopamine receptors. We also highlight the pivotal role of these receptors in the modulation of neurogenesis, a possible therapeutic target that might help to slow down the process of neurodegeneration.
Viral Marketing and the Diffusion of Trends on Social Networks (2008)

We survey the recent literature on theoretical models of diffusion in social networks and the application of these models to viral marketing. To put this work in context, we begin with a review of the most common models that have been examined in the economics and sociology literature, including local interaction games, threshold models, and cascade models, in addition to a family of models based on Markov random fields. We then discuss a series of recent algorithmic and analytical results that have emerged from the computer science community. The first set of results addresses the problem of influence maximization, in which the goal is to determine the optimal group of individuals in a social network to target with an advertising campaign in order to cause a new product or technology to spread throughout the network. We then discuss an analysis of the properties of graphs that allow or prohibit the widespread propagation of trends. 1 1
Flame Sprayed Plastic Coatings (1951)

The history of flame spraying is briefly reviewed. Both guns and powder containers used for applying flame sprayed coatings of plastic powders are described in some detail. Necessary criteria for organic materials both thermoplastic and thermosetting are indicated. Problems involved in producing suitable powders of tough non-friable resins are discussed and indications given of several promising solutions. Properties of flame sprayed Thiokol (a polysulphide synthetic rubber) coatings are reviewed in some detail. Recent work on improvements in flame spraying technique are illustrated by a discussion of the advances in the flame spraying of various polyethylene compounds. This includes comments on current theory, various fuel gas combinations and polyethylene compounding for obtaining specific properties in flame sprayed coatings. Some data is presented on the effect of after-treatments of flame sprayed plastic coatings. Experimental work being done on producing flame sprayed coatings of fluorinated hydro-carbons is described, and a preliminary report given on the properties of these coatings. Recent developments in the technique for producing smooth non-porous coatings of hot melt compositions is discussed in some detail. Procedures developed for producing sprayable powders of hot melt composition and for stabilizing them for storage are described. An indication is given of results obtained to date and probable effect of future developments in this field. In an attempt to indicate how the corrosion engineer can evaluate the suitability of flame sprayed plastic coatings for a particular corrosion problem, the history of several successful applications is reviewed.