gebhart/patrepeval huggingface dataset:
Control of the splanchnic circulation. (1977)

The major regulatory factors in the mesenteric circulation include general hemodynamic forces, the autonomic nervous system, circulating vasoactive substances, tissue metabolites and intrinsic characteristics of vascular smooth muscle. During mesenteric ischemic states smooth muscle spasm elevates resistance to blood flow and aggravates intestinal tissue hypoxia leading to mucosal necrosis. Close intraarterial infusion of potent vasodilator drugs holds the promise of reversing intestinal ischemia and preserving viability of the gut.
Calibrations of phase and ratio errors of current and voltage channels of energy meter (2013)

This paper deals with measurement of phase and ratio errors of current and voltage channels of a new produced energy meter. This fully digitally controlled energy meter combines the classical static energy meter with power quality analyzer. The calibration of phase and ratio errors in wide frequency range is then necessary. Paper shows the results of error measurement, introduces the mathematical approximations and describes the calibration constants. It allows error compensation and power calculation of particular harmonics. The electric power of the higher harmonics can be interesting information of distributed electric energy quality.
Response to Diazepam in Sons of Alcoholics (1992)

Alcohol exerts several of its actions via the chloride channel associated with the central GABA-benzodiazepine receptor complex. To explore a possible role for this receptor complex in risk for alcoholism, and to determine whether risk for alcoholism is associated with risk for benzodiazepine abuse, the authors administered intravenous diazepam to 18 sons of male alcoholics (SOAs) and 18 control subjects. Four logarithmically increasing doses of diazepam and matched volumes of placebo were given in randomized order on separate days about 1 week apart. SOAs were significantly more likely than controls to report euphoric responses to diazepam. At some diazepam doses, SOAs were more likely to report feeling "high" and "intoxicated." SOAs and controls did not differ in feeling "drugged." SOAs and controls may differ in expectations regarding the subjective effects of drugs and/or in the function of the central GABA-benzodiazepine receptor complex. These findings also add further evidence for increased pleasurable effects, and thus possibly increased risk for benzodiazepine abuse, in a subgroup of SOAs.
IκB Kinase α Regulates Subcellular Distribution and Turnover of Cyclin D1 by Phosphorylation (2005)

IkappaB kinases (IKKs), IKKalpha and IKKbeta, with a regulatory subunit IKKgamma/NEMO constitute a high molecular weight IKK complex that regulates NF-kappaB activity. Although IKKalpha and IKKbeta share structural and biochemical similarities, IKKalpha has been shown to have distinct biological roles. Here we show that IKKalpha plays a critical role in regulating cyclin D1 during the cell cycle. Analysis of IKKalpha-/- mouse embryo fibroblast cells showed that cyclin D1 is overexpressed and localized in the nucleus compared with parental mouse embryo fibroblasts. IKKalpha associates with and phosphorylates cyclin D1. Analysis on cyclin D1 mutants demonstrated that IKKalpha phosphorylates cyclin D1 at Thr286. Reconstitution of IKKalpha in knockout cells leads to nuclear export and increased degradation of cyclin D1. Further, RNAi-mediated knockdown of IKKalpha results in similar changes as observed in IKKalpha-/- cells. These results suggest a novel role of IKKalpha in regulating subcellular localization and proteolysis of cyclin D1 by phosphorylation of cyclin D1 at Thr286, the same residue earlier found to be a target for glycogen synthase kinase-3beta-induced phosphorylation.
Crystal Structure (2012)

Abstract This chapter presents forty-seven problems covering the subject of crystal structure, along with their corresponding solutions.
CARMA: Composable-Adaptive Resource Management Authorization for ubiquitous environments (2010)

The ever increasing diversity and mobility of devices have originated a marked rise in ubiquitous resources; a great number of collaborative applications could be exploited just by employing an efficient ubiquitous resource management mechanism. The CARM (Composable-Adaptive Resource Management) middleware-based architecture provides a flexible infrastructure where personal devices create seamlessly on demand interconnections links to share ubiquitous resources. In this article we address CARM's security challenges and to overcome these we propose the CARM Authorization (CARMA) module; in CARMA each user acts as an Attribute Authority (AA) responsible of issuing Attribute Certificates (ACs) and defining for each resource a set of policy-based authorization decisions; CARMA's Alerting System (AS) allows users to work in a collaborative mode by warning others of malicious nodes even when no infrastructure is available. This research mainly describes ongoing work towards a proof-of-concept implementation in the given scenarios. Our proposal enforces security considering the bandwidth efficiency and therefore enhancing the dynamic resource management experience in ubiquitous environments.
The Nervous System at the Cellular Level (1967)

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More
Malware Detection Using Machine Learning Based on the Combination of Dynamic and Static Features (2018)

As millions of new malware samples emerge every day, traditional malware detection techniques are no longer adequate. Static analysis methods, such as file signature, fail to detect unknown programs. Dynamic analysis methods have low efficiency and high false positive rate. We need a detection technique that can adapt to the rapidly changing malware ecosystem. The paper presented a new malware detection method using machine learning based on the combination of dynamic and static features. The characteristic of this experiment involved in many fields of knowledge, including binary program instrumentation, static analysis, assembly instruction analysis, machine learning, etc. Finally, we achieved a good result over a substantial number of malwares.
An Empirical Correlation Between Reservoir Temperature and the Concentration of Hydrogen Sulfide (1999)

Abstract The problem addressed in this paper was to establish an empirical correlation between the H2S concentration in reservoir fluids and the reservoir temperature. The work is based on data from a large number of exploration wells drilled in sandstone reservoirs on the Norwegian continental shelf. It is shown that with few exceptions, the H2S concentration in the produced fluid is close to zero, when the reservoir temperature is below a threshold temperature of about 220°F (105°C). Above this threshold, an exponential temperature dependency is shown to exist. The empirical correlations developed in this work allow a reasonably accurate estimate of the expected H2S in produced gas. They are considered of particular importance for early planning of H2S control strategies and production management, especially in cases where only wireline formation tests have been conducted.
Anaphase Inactivation of the Spindle Checkpoint (2006)

The spindle checkpoint delays cell cycle progression until microtubules attach each pair of sister chromosomes to opposite poles of the mitotic spindle. Following sister chromatid separation, however, the checkpoint ignores chromosomes whose kinetochores are attached to only one spindle pole, a state that activates the checkpoint prior to metaphase. We demonstrate that, in budding yeast, mutual inhibition between the anaphase-promoting complex (APC) and Mps1, an essential component of the checkpoint, leads to sustained inactivation of the spindle checkpoint. Mps1 protein abundance decreases in anaphase, and Mps1 is a target of the APC. Furthermore, expression of Mps1 in anaphase, or repression of the APC in anaphase, reactivates the spindle checkpoint. This APC-Mps1 feedback circuit allows cells to irreversibly inactivate the checkpoint during anaphase.
Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine (2003)

4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to interact with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the synthesized compounds on inflammation, using the carrageenin induced mice paw edema model was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
Embedding information within dynamic visual patterns (2005)

There exist many scenarios in which the automatic distinction between human and machines is desirable. This paper describes a texture-image based approach to encode text information in such a way that machine vision algorithms will experience difficulties while humans can extract the embedded text effortlessly. We exploit both static and dynamic visual patterns to diversify the image content and discourage automatic processing. Examples of the resulting patterns are presented and their properties are discussed.
An instruction set and microarchitecture for instruction level distributed processing (2002)

An instruction set architecture (ISA) suitable for future microprocessor design constraints is proposed. The ISA has hierarchical register files with a small number of accumulators at the top. The instruction stream is divided into chains of dependent instructions (strands) where intra-strand dependences are passed through the accumulator. The general-purpose register file is used for communication between strands and for holding global values that have many consumers.A microarchitecture to support the proposed ISA is proposed and evaluated. The microarchitecture consists of multiple, distributed processing elements. Each PE contains an instruction issue FIFO, a local register (accumulator) and local copy of register file. The overall simplicity, hierarchical value communication, and distributed implementation will provide a very high clock speed and a relatively short pipeline while maintaining a form of superscalar out-of-order execution.Detailed timing simulations using translated program traces show the proposed microarchitecture is tolerant of global wire latencies. Ignoring the significant clock frequency advantages, a microarchitecture that supports a 4-wide fetch/decode pipeline, 8 serial PEs, and a two-cycle inter-PE communication latency performs as well as a conventional 4-way out-of-order superscalar processor.
Mechanical properties and shear failure surfaces of two alumina powders in triaxial compression (2000)

In the manufacture of ceramic components, near-net-shape parts are commonly formed by uniaxially pressing granulated powders in rigid dies. Density gradients that are introduced into a powder compact during press-forming often increase the cost of manufacturing, and can degrade the performance and reliability of the finished part. Finite element method (FEM) modeling can be used to predict powder compaction response, and can provide insight into the causes of density gradients in green powder compacts; however, accurate numerical simulations require accurate material properties and realistic constitutive laws. To support an effort to implement an advanced cap plasticity model within the finite element framework to realistically simulate powder compaction, the authors have undertaken a project to directly measure as many of the requisite powder properties for modeling as possible. A soil mechanics approach has been refined and used to measure the pressure dependent properties of ceramic powders up to 68.9 MPa (10,000 psi). Due to the large strains associated with compacting low bulk density ceramic powders, a two-stage process was developed to accurately determine the pressure-density relationship of a ceramic powder in hydrostatic compression, and the properties of that same powder compact under deviatoric loading at the same specific pressures. Using this approach, the seven parameters that are required for application of a modified Drucker-Prager cap plasticity model were determined directly. The details of the experimental techniques used to obtain the modeling parameters and the results for two different granulated alumina powders are presented.
Preparation of lithio ethyl acetate. Procedure for the conversion of aldehydes and ketones to .beta.-hydroxy esters (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of lithio ethyl acetate. Procedure for the conversion of aldehydes and ketones to .beta.-hydroxy estersMichael W. RathkeCite this: J. Am. Chem. Soc. 1970, 92, 10, 3222–3223Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 May 1970https://pubs.acs.org/doi/10.1021/ja00713a071https://doi.org/10.1021/ja00713a071research-articleACS PublicationsRequest reuse permissionsArticle Views904Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reduction of the Toxicity and Mutagenicity of Aziridine in Mammalian Cells Harboring the Escherichia Coli fpg Gene (1996)

Aziridine (ethyleneimine) reacts with DNA in vitro, mainly at the N7 position of guanine and N3 of adenine, then imidazole ring opening of the modified guanine results in formation of formamidopyrimidine (FaPy) residues. The Escherichia coli fpg gene encodes a DNA glycosylase that removes FaPy residues from DNA. To determine whether aziridine produces FaPy lesions in mammalian cells we have expressed the E.coli fpg gene in CHO cells. The transfected cells, expressing high levels of the bacterial protein, are more resistant to the toxic and mutagenic effects of aziridine than the control population. Less DNA damage was measured by quantitative PCR analysis in transfected than in control cells treated with equimolar concentrations of aziridine. The results suggest that aziridine produces in vivo FaPy residues that could account for the deleterious effects of this compound.
Coordination‐Driven In Situ Self‐Assembly Strategy for the Preparation of Metal–Organic Framework Hybrid Membranes (2014)

Metal-organic frameworks (MOFs) have emerged as porous solids of a superior type for the fabrication of membranes. However, it is still challenging to prepare a uniformly dispersed robust MOF hybrid membrane. Herein, we propose a simple and powerful strategy, namely, coordination-driven in situ self-assembly, for the fabrication of MOF hybrid membranes. On the basis of the coordination interactions between metal ions and ligands and/or the functional groups of the organic polymer, this method was confirmed to be feasible for the production of a stable membrane with greatly improved MOF-particle dispersion in and compatibility with the polymer, thus providing outstanding separation ability. As an experimental proof of concept, a high-quality ZIF-8/PSS membrane was fabricated that showed excellent performance in the nanofiltration and separation of dyes from water.
On syntomic regulators I: constructions (2016)

We show that classical Chern classes from higher ($p$-adic) $K$-theory to syntomic cohomology extend to logarithmic syntomic cohomology. These Chern classes are compatible -- in a suitable sense -- with addition, products, and $λ$-operations. They are also compatible with the canonical Gysin sequences and, via period maps, with logarithmic étale Chern classes. Moreover, they induce logarithmic crystalline Chern classes. This uses as a critical new ingredient the recent comparison of syntomic cohomology with $p$-adic nearby cycles and $p$-adic motivic cohomology.
Building a B.S. Degree Program in E-Business (2002)

An assortment of courses, minors, majors, degree and certificate programs, and “centers” addressing internet marketing, e-commerce, and e-business is emanating from colleges and universities globally. There's no debate regarding the appropriateness of incorporating into curricula “digital” content, nor does there seem to be contention regarding relevant topical coverage. Whether to integrate digital content into existing course work or create a dedicated curriculum is a “hot button.” This article describes the authors’ experience in addressing these matters as they work to implement a B.S. degree program in e-business at their state supported institution.
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models (2016)

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a cha
Learning-based three dimensional sound localization using a compact non-coplanar array of microphones (1997)

One of the various human sensory capabilities is to identify the direction of perceived sounds. The goal of this work is to study sound source localization in three dimensions using some of the most important cues the human uses. Having robotics as a major application, the approach involves a compact sensor structure that can be placed on a mobile platform. The objective is to estimate the relative sound source position in three dimensional space without imposing excessive restrictions on its spatio-temporal characteristics and the environment structure. Two types of features are considered, interaural time and level differences. Their relative effectiveness for localization is studied, as well as a practical way of using these complementary parameters. A two-stage procedure was used. In the training stage, sound samples are produced from points with known coordinates and then are stored. In the recognition stage, unknown sounds are processed by the trained system t...
SUMMARY REPORT ON FATIGUE RESPONSE OF ASPHALT MIXTURES (1990)

This report evaluates test procedures for measuring the fatigue response of asphalt paving mixtures, and summarizes current knowledge of the factors that influence fatigue response. Available test methods are classified, and criteria used to evaluate each method for its potential use as a laboratory standard are discussed. The 3 most promising methods are considered to be simple flexure, diametral fatigue, and tests based on fracture mechanics principles. Factors affecting fatigue repsonse include specimen fabrication, mode of laoding, mixture variables, and loading and environmental variables. Mode of loading, typically either controlled-stress or controlled-strain for laboratory testing, is one of the primary factors affecting fatigue response. Air void content and temperature, both affecting mixture stiffness, may have more significant influence on fatigue repsonse than any other variable. Many mixture, load, and environmental factors also influence fatigue respose and must be considered both in the development of test protocols and in the determination of asphalt and mixture properties that are essential for fatigue-resistant pavements.
The Development and Testing of External Emergency Procedures at Royal Hobart Hospital (1997)

The Counter-Disaster Committee updates the Royal Hobart Hospital (RHH) Counter-Disaster Plan in order to overcome the inadequacy of the existing plan in relation to Standards Australia requirements. Several areas like call-in procedures, recovery process and relief and communications are identified for improvements, as these areas are poorly addressed in the emergency plan.
BRUCELLOSE BOVINE EXPÉRIMENTALE II. -- RÉPARTITION DE BRUCELLA ABORTUS DANS L'ORGANISME SIX SEMAINES APRÈS LE PART ET TROIS MOIS A CINQ MOIS ET DEMI APRÈS L'ÉPREUVE INFECTANTE (1970)

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Adiabatic Rapid Passage in Ruby at 8 mm Wavelengths† (1961)

ABSTRACT An investigation of adiabatic rapid passage has been made in ruby at 8 mm wavelengths. Performance data are given on a two-level ruby maser operated both as a pulsed amplifier and as an oscillator at these wavelengths. When amplifying, values of gain and bandwidth of up to about 14 ds and 10 Mc/ s at 1-4° k were obtained, giving root gain-bandwidth products of up to about 50 Mc/ s. In preliminary experiments using the maser as an oscillator output powers of about 70 / z/ v at 33-1 Gc/ s were obtained at 1. 4° K. The inversion technique used, which incorporates magnetic field modulation with the use of the crystal as a cavity, could be readily scaled to considerably higher frequencies.
High-Temperature Superconductors - A Material for Miniaturized or High-Performance Microwave Components (1990)

After a brief phenomenological introduction of microwave superconductivity by means of the two-fluid model the conductivity parameter of present YBa 2 Cu 3 O 7-x high-T c films are given. Based on these data it is shown that for frequencies below 100 GHz passive microwave components with much higher electrical performance or with considerably reduced geometrical size can be realized.
Gestaltung von problembasierten Lernumgebungen (Problem-based Learning) : eine Analyse aus motivations- und kognitionspsychologischer Sicht (2008)

Problembasiertes Lernen (Problem-based Learning) hat sich in den letzten Jahren auch in der Wirtschaftsbildung verbreitet. In diesem Artikel wird in einem ersten Schritt der Forschungsstand zu Problem-based Learning (PBL) zusammengefasst und dabei insbesondere auf die Lerneffektivität von PBL in empirischen Vergleichsstudien eingegangen. Anschliessend werden die Ergebnisse auf Grund von aktuellen kognitions- und motivationspsychologischen Theorien und Befunden diskutiert und Schlussfolgerungen zur Gestaltung von problembasierten Lernumgebungen gezogen.
U-City User Authentication Methods and Encryption Techniques Based on Biometric Technology (2007)

This paper proposes user authentication methods and encryption techniques that support reliable u-City user authentication services, based on biometric technology, (the use of face, vein, fingerprint, and iris recognition). Even in an advanced wire/wireless network environment, there remain the possibilities that personal confidential information may be exposed. Therefore, this paper proposes a method that prevents damage and effectively copes with security vulnerabilities, using an encryption method that applies to characteristics information twice, in addition to an authentication method based on biometric technology. The proposed user authentication technique randomly selects several biometric information items at the time of authentication, and applies more than two items of biometric information. In addition, the proposed encryption technique uses double encryption, utilizing the user's biometric characteristics information. This paper aims to guarantee an efficient and reliable user authentication service in a u-City environment, based on this methodology.