gebhart/patrepeval huggingface dataset:
The Influence of Thermal Treatment on the Release Behavior of Diclofenac Sodium from Acrylic Matrices (2005)

The objective of this work was to investigate the effect of thermal treating on the release rate of diclofenac sodium from Eudragit RS and Eudragit RL matrices. Eudragit RS and RL are nonswelling polymers that have a low glass transition (Tg) temperature. The matrices were thermally treated at different temperatures (40, 50, 60, and 70 degrees C) for different periods of times (2, 5, and 24 h). The results showed that thermal treating at temperatures less than the Tg of the polymer has no effect on the release of the drug, whereas heat-treating at temperatures higher than the Tg decreases the release rate of diclofenac sodium from matrices. It was shown that the duration of heat treatment was also an important factor in controlling the release rate of diclofenac sodium from Eudragit matrices. The results showed that an increase in the duration of heat treatment from 2 h to 24 h resulted in a reduction in the release rate of the drug. Scanning electron microscopy of the cross section of the tablet before and after heat treating showed that the tablets were deformed and fused into a continuous and homogeneous structure after heat treating. Thermally treated tablets demonstrated fewer surface defects than did nonthermally treated tablets. These structural changes in the tablet compacts resulted in a matrix structure that decreased the release rate of the diclofenac sodium from Eudragit matrices
CONVERSION OF [4-14C]PROGESTERONE TO ANDROSTERONE BY FEMALE RHESUS MONKEYS (MACACA MULATTA) (1971)

SUMMARY Labelled progesterone was administered intravenously to five, adult female rhesus monkeys and urine and faeces were collected every 24 h. Excretion of radioactivity in urine occurred most rapidly in the first 24-h period and then declined exponentially. The excretion of radioactivity in faeces reached maxima during the 2nd, 3rd or 4th 24-h periods depending on the animal studied. 76–94% (mean 86%) of the radioactivity administered was recovered within 9 days, but small quantities continued to be excreted in urine up to 16 days after injection. Generally, greater amounts of radioactivity were recovered from faeces (41–57%) than from urine (26–48%). Using different hydrolytic and extraction procedures, some 50% of the radioactivity in urine was recovered in the neutral extracts. The major metabolite in urine was androsterone which accounted for 1·1–12·2% (mean 6·0%) of the progesterone administered. Pregnanediol was not an important urinary catabolite in this species. Differences in the extent to which progesterone is metabolized to C-19 compounds in macaques, baboons, great apes and man may reflect the phylogeny of a catabolic desmolase system in anthropoid primates.
An automatic transformation from COSA software architecture to CORBA platform (2008)

Recently, middleware as an abstraction layer is completely integrated in development environments for resolving heterogeneity and guaranteeing the transparency communication of distributed components. The explicit separation of architecture and implementation is the main concern of the Model Driven Architecture (MDA), aiming to well understanding and controlling interactions and inter-connections among components. This article defines an automatic transformation from COSA (Component-Object based Software Architecture), which is a software architecture model that describes systems as a collection of components and connectors, to a standard platform - CORBA. The goal of our work is rapid mapping and smooth integration of COSA concepts into CORBA middleware platform in order to achieve a higher level of abstraction.
Relationships and Contracts (1995)

Abstract Following an understanding of the relationships that form a firm, two main types of commercial relationships are recognized. Spot contracts refer to agreements for immediate exchanges, whereas relational contracts occur in cases in which the companies involved face a ‘repeated game’. The appropriateness of each depends on the specific circumstances of the exchange.
The role of EZH2 in tumour progression (2011)

Accumulated evidence shows that EZH2 is deregulated in a wide range of cancer types, and it has a crucial role in stem cell maintenance and tumour development. Therefore, blocking EZH2 expression or activity may represent a promising strategy for anticancer treatment. In this review, we address the current understanding of the mechanisms underlying EZH2 regulation alongside the function of EZH2 gene targets that are involved in cancer progression. Finally, we will describe cancer therapies that target EZH2 or its downstream cascades, which could potentially reverse the oncogenic and stemness properties of the tumour cells to suppress cancer progression and recurrence.
Effect of Silver on the Sintering and Grain‐Growth Behavior of Barium Titanate (2000)

Silver and its alloys frequently are used as electrode material for BaTiO 3 ‐based dielectrics. In the present study, a small amount of fine silver particles have been intimately mixed with BaTiO 3 powder. The sintering and grain‐growth behavior of the silver‐doped BaTiO 3 in air are investigated. The solubility of silver in BaTiO 3 , as revealed by lattice‐parameter measurement, electrical measurement, and electron probe microanalysis, is <300 ppm. The densification of BaTiO 3 is slowed slightly by the addition of silver inclusions. However, the presence of a small amount (<0.3 wt%) of silver increases the amount and size of abnormal grains. When the silver content is >0.3 wt%, the grain growth of BaTiO 3 then is prohibited by the silver inclusions.
Activation of nonspecific killer cells by interleukin 2-containing supernatants. (1983)

In the absence of specific antigen stimulation, nonspecific killer cells were induced by culturing C57BL/6 lymph node or spleen cells with interleukin 2-containing supernatants. These supernatants were obtained from stimulation of either rat spleen cells with concanavalin A or a variant of the T cell lymphoma, EL4 (H-2b) with phorbol myristic acetate. The ability of the EL4 supernatant to induce nonspecific killer cells was abrogated by absorption with an interleukin 2-dependent T cell line or by concanavalin A-stimulated spleen cell blasts, but not by lipopolysaccharide-stimulated spleen cell blasts or by a non-interleukin 2-producing EL4 line. Partially purified interleukin 2 from EL4 supernatants could also support nonspecific killer cell induction. The induction of cytolytic cells by interleukin 2 is sensitive to gamma-irradiation and has a D omicron of 120 rad. The nonspecific killer cells induced are likely cytotoxic T lymphocytes; the majority of the precursor and effector cells bear the Thy-1 alloantigen marker. These nonspecific killer cells killed a broad spectrum of target cells, including concanavalin A- and lipopolysaccharide-induced splenic blasts of syngeneic or allogeneic mice, a syngeneic tumor, and a cloned allogeneic cytotoxic T cell line. The frequency of precursors for nonspecific killer cells in C57BL/6 lymph node and spleen cells are 1/7000 and 1/12,000, respectively. Clonal analyses revealed that these nonspecific killers exhibit heterogeneity with respect to their target cell specificities. The induction of nonspecific killers by interleukin 2-containing supernatants is partially dependent on nylon wool-adherent cells; in antigen-stimulated cultures the most specific killer cells were obtained from cultures in which nylon wool-nonadherent lymph node responder cells were stimulated with nylon wool-nonadherent allogeneic splenic stimulator cells that were treated with anti-Thy-1 antibody and complement. The relevance of these findings with respect to the frequencies and fine specificities of cytotoxic T lymphocytes generated in interleukin 2-supplemented cultures is discussed.
Prozessnahes Qualitätsmanagement beim Lasersintern von Polyamid 12 (2014)

A process related quality management method for the compensation of Polyamide 12 (PA 12) induced process and part properties deviations is presented as a basic concept for a quality assured series laser sintering production.In this context, deviations are caused by a strong interaction between the material and the process leading to an undesired deviation of part properties.With regard to laser sintering, material property changes occur due to processing conditions.Thermorheological investigations of systematically under process related condition aged PA 12 powders revealed a significant dependence of property changes to a combined time and temperature effect.With respect to these findings, a model was derived that is able to describe these property changes.Moreover, the model was used under utilization of processing knowledge within a model based predictive quality control and verified experimentally based on a relationship between process properties and model prediction.In addition, this relationship was used to define a processing window for process and material properties.The validation of the model based predictive quality control was done by a comparison of part properties whereas parts were produced based on a predicted parameter setup that represented a processing state inside and outside of the defined processing window.However, a clear confirmation for the effectiveness of the model based quality assurance in this study could not be concluded.Mainly, this result was reduced to differences between model prediction and experiment, i.e. differences that are related to the inhomogeneity of the melting characteristic and the sintering process which hence control the properties profile of additively manufactured parts as well as its deviations.
On the closure of characters and the zeros of entire functions (1967)

The problem to be studied in this paper concerns the closure properties on an interval of a set of characters {e~nx}~, where A = {2n}~ is a given set of real or complex numbers without finite point of accumulation. This problem is for obvious reasons depending on the distribution of zeros of certain entire functions of exponential type. The main problem of the paper is to determine the closure radius Q = Q(A)defined as the upper bound of numbers r such that (ei~x)~EA span the space L 2 ( r , r ) . The value of r does not change if a finite number of points are removed from or adjoined to A. Nor does Q(A) change if the metric in the previous definition is replaced by any other LV-metric, or by a variety of other topologies. I f A contains complex numbers we shall always assume (1)< 6~t ~ (0.1) 9 ~eA ~
Gestational Diabetes Mellitus in Women of Single Gravidity in Tianjin City, China (2002)

The prevalence of GDM in pregnant women in the city of Tianjin, China, was 2.31%. Short stature and smoking in pregnancy were additional risk factors for GDM.
Multiple-allelomorph Incompatibility of Pollen and Style in the Evolution of the Angiosperms (1950)

Journal Article Multiple-allelomorph Incompatibility of Pollen and Style in the Evolution of the Angiosperms Get access H. L. K. WHITEHOUSE H. L. K. WHITEHOUSE Botany SchoolCambridge Search for other works by this author on: Oxford Academic PubMed Google Scholar Annals of Botany, Volume 14, Issue 2, April 1950, Pages 199–216, https://doi.org/10.1093/oxfordjournals.aob.a083243 Published: 01 April 1950
Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease. (1990)

Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients with dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing of the occipital regions in DAT. Normalisation to occipital flow illustrated highly significant CBF deficits in a number of cortical regions, particularly in the left and right posterior--temporal cortex in DAT compared to controls. The cognitive performance of DAT patients was measured using a clinical cognitive assessment procedure (CAMCOG) and numerous correlations between these scores and rCBF were obtained. The implications and value of this investigative technique are discussed.
Parallel pattern mining - application of GSP algorithm for Graphics Processing Units (2012)

Frequent pattern mining is the field with many practical applications, where large computational power and speed are needed. Many solutions, both software and hardware, are proposed for those applications, but specialised solutions in form of embedded systems are not so common as one could imagine. This is especially true when we consider problems that can be paralleled. Many of the state-of-the-art frequent pattern mining applications are inefficient when used on shared memory systems or multiprocessor systems. To solve this problem both hardware and software solutions are proposed - remapping system architecture, improving memory performance, modifying task allocation. This article proposes modification of classical frequent pattern mining algorithms from Apriori family, illustrated with the example of popular GSP algorithm. Addition of GPU (Graphics Processing Unit) or multiple GPUs to embedded system is proposed and algorithm is modified in such a way, that it is best suited for solving GPGPU (general-purpose computation on graphics hardware) problems. Both theoretical and experimental evaluation of modifications are made, the latter with use of setup consisting of NVIDIA Tesla card and CUDA parallel computing platform. It is shown in the article, that for tested data sets modified GSP algorithm finishes finding frequent sequences 50-100 times faster and with the same accuracy. Such speed-up allows the use of classical pattern mining algorithms for real-time solutions. This also permits broader scope of algorithms to be used in embedded systems with real-time constraints.
High-dose cytarabine dose modification reduces the incidence of neurotoxicity in patients with renal insufficiency. (1997)

HDAC NT is strongly associated with RI. The risk of HDAC NT can be reduced by the following: (1) routinely reducing the ARA-C dose from 3 to 2 g/m2 per dose; (2) modifying the ARA-C dose based on daily Cr values; and (3) administering HDAC on a once-daily rather than twice-daily schedule.
Naloxone Partly Counteracts Apomorphine Side Effects (1991)

The effects of naloxone on side effects provoked by apomorphine (APO) administration in patients with parkinsonian syndrome have been studied. The group under study included eight patients with Parkinson's disease and four with parkinsonism who received 100 micrograms/kg s.c. APO acutely to test dopaminergic responsiveness. All patients were treated with 20 mg domperidone tablets t.i.d. and then for 2 consecutive days (in double blind fashion) were given a 2-hour i.v. saline infusion alone or with naloxone (8 mg) starting 30 min before APO administration. In both groups, naloxone delayed the appearance of sleepiness, and reduced the intensity of yawning, sleepiness, nausea, and vomiting as compared with saline. These findings indicate a potential usefulness of naloxone and other opioid antagonists in preventing acute APO side effects.
Magnetic first-order phase transition in MnAs films (1970)

For polycrystalline and epitaxial films of MnAs, the magnetic phase transformation from the ferromagnetic to the paramagnetic phase was studied. It was found that the films which are removed from the substrate undergo an abrupt loss of magnetization near 38°C within a temperature interval of 0.2°C. They exhibit a temperature hysteresis of 5°C. Films clamped to thick inflexible substrates show a second-order phase transition and a shift in Curie temperature of 35°C per 1-percent volume change due to a difference in thermal expansion coefficient between film and substrate. MnAs films on highly flexible thin plastic foils exhibit a first-order-like phase transition. First-order transition films show a drastic change in resistivity ρ due to microcracks. At 20°C ρ of the virgin film is 1.93 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> Ω cm and increases irreversibly to 6.0 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> Ω cm after 15 transitions. The reversible change varies between a factor of 2.5-3.5. The Hall voltage <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">U_{H} = (R_{0}H + R_{1}M) i/d</tex> was measured and the Hall constants R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> and R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> were calculated to be 2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> and 0.33 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /A.s respectively, at 20°C.
Automated 3D reconstruction of neuronal structures from serial sections (1999)

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La construcción de la fábrica y la invención del pueblo de Santa Rosa, Veracruz (1993)

Gracias a la utilización de fuentes documentales empresariales, recientemente reorganizadas, es posible conocer, de manera detallada, el proceso de construcción de la fábrica «Santa Rosa», que ocurrió hace poco más de un siglo. Esto no es común, pues son pocos los casos en que se puede disponer de la información necesaria para reconstruir este proceso de instalación de una gran factoría en el Porfiriato. A través de la lectura de las Actas de Deliberación del Consejo de Administración de la Compañía Industrial Veracruzana (civsa) podemos seguir en forma por demás pormenorizada el proceso de construcción de la fábrica de «Santa Rosa» y la creación del pueblo fabril que pronto comenzó a crecer en sus alrededores.
종설 : 망상개념의 역사적 개관 (2008)

Delusion existed from the prehistoric age and the concept of delusion has changed according to times and culture. Delusion is relatively easy to diagnose but difficult to understand. We reviewed the concept of delusion from prehistoric age to 20th century including Greek period, Roman period, the middle ages, and the modern period. In Greek and Roman period, Hippocrates made his case that mental disorder was disease of brain against those days belief that it was the Heaven`s justice and Asklepiades drew a line between delusion and hallucination from one concept of phantasia. Go through the Dark ages, even though age of reason, we still lived under the philosophy of religion, but there was the opinion that mental disorder was disease of brain and to be insane was to have delusion and vice versa. The concept of delusion of the 18th century based on speculative neurobiology progressed to the 19th century model; to be insane was to have delusions which was called the intellectualist view of insanity and delusions resulted from failures in the apparatus that served to acquire experiences. The view that delusions are ``wrong beliefs``, was first formulated during the 19th century. By the end of the 19th century, the concept of as a morbid belief had become well established. In the 20th century, there were Karl Jaspers, Kurt Schneider of Heidelberg school. We hope that this review help understand the concept of delusion more easily.
Wing-Box Weight Optimization Using Curvilinear Spars and Ribs (SpaRibs) (2011)

The aim of this research is to perform topology and sizing optimization of wing-box structures using curvilinear spars and ribs, referred to as SpaRibs in the following. To accomplish this, a new framework calledEBF3SSWingOpt is being developed at Virginia Polytechnic Institute and State University. The optimization framework includes two different methodologies: a one-step optimization methodology where topology and sizing optimization are carried out together and a two-step optimization methodology where topology and sizing optimization are carried out separately using different constraints and objective functions. A description of how the general framework is developed and applied for optimizing winglike structures is provided and the optimization-problem formulation is stated. Two practical design problems solved using EBF3SSWingOpt are presented: a rectangular wing box and a generic fighter wing. In both cases, the structure with the SpaRibs is lighter than the initial structure with straight spars and ribs.Moreover, the two-step optimization framework has proven to be better atfinding anoptimal solution than the one-step framework. Finally, different designs with comparable weights but different stress distributions, buckling properties, and dynamic behaviors were found.
Host Plant Associations of an Entomopathogenic Variety of the Fungus,<i>Colletotrichum acutatum</i>, Recovered from the Elongate Hemlock Scale,<i>Fiorinia externa</i> (2009)

A fungal epizootic has been detected in populations of the scale Fiorinia externa Ferris (Hemiptera: Diaspididae) in the eastern hemlock, Tsuga canadensis (L.) Carrière (Pinales: Pinaceae), of several northeastern states. Colletotrichum acutatum Simmonds var. fioriniae Marcelino and Gouli var. nov. inedit (Phyllachorales: Phyllachoraceae), a well-known plant pathogen, was the most commonly recovered fungus from these infected scales. This is the second report of a Colletotrichum sp. infecting scale insects. In Brazil C. gloeosporioides f. sp. ortheziidae recovered from Orthezia praelonga is under development as a biopesticide for citrus production. C. acutatum was detected growing endophytically in 28 species of plants within the epizootic areas. DNA sequences of the High Mobility Box at the MAT 1-2, mating type gene indicate that Colletotrichum sp. isolates recovered from scale insects and plants within epizootic areas were identical. Results from plant bioassays showed that this entomopathogenic Colletotrichum variety grew endophytically in all of the plants tested without causing external symptoms or signs of infection, with the exception of strawberry plants where mild symptoms of infection were observed. The implications of these findings with respect to the use of this fungus as a biological control agent are discussed.
Modeling the Environmental Fate of Microorganisms (1991)

Addresses the application of statistical modeling to studies on the ability of microorganisms to persist in and potentially be transported through the environment following their deliberate or accidental release. Also covers the use of chemical disinfectants to minimize waterborne disease hazards, a