gebhart/patrepeval huggingface dataset:
Interaction between histamine and vagal stimulation on tracheal smooth muscle in dogs (1984)

We examined the interaction between histamine and vagal efferent activity on airway smooth muscle reactivity in 11 anesthetized vagotomized dogs using an isolated closed segment of the intrathoracic trachea filled with Tyrode solution under an isovolumetric condition. Intratracheal pressure change was measured as an index of tracheal smooth muscle tone. The administration into the tracheal segment of histamine (0.1 or 1.0 mg/ml) in six dogs and methacholine chloride (0.001 or 0.01 mg/ml) in the other five dogs elevated intratracheal pressure by about 5 cmH2O. The electrical stimulation of the peripheral ends of both of the cut cervical vagus nerves in the presence of histamine produced significantly greater responses than the additive responses of these two stimuli applied individually (two-way analysis of variance, P less than 0.025). However, the combined effects of vagal stimulation and methacholine were not significantly different from the additive responses of these two stimuli applied individually. The average values of intratracheal pressure elevated by the combined effects of vagal stimulation and histamine were significantly higher than those obtained by the combination of vagal stimulation and methacholine (two-way analysis of variance, P less than 0.01). This suggests that histamine potentiates tracheal smooth muscle reactivity to electrical vagal stimulation, which may contribute to the hyperreactivity observed in patients with asthma.
Predicting High Grade Lesions of Sinusoidal Obstruction Syndrome Related to Oxaliplatin-Based Chemotherapy for Colorectal Liver Metastases (2010)

A low preoperative platelet count and high APRI score seem to be the most reliable indicators to predict SOS severity.
Pleural-fluid myeloperoxidase in complicated and noncomplicated parapneumonic pleural effusions (2002)

The diagnostic accuracy of myeloperoxidase (MPO) in pleural fluid, for differentiating between complicated and noncomplicated parapneumonic pleural effusions (PPE) evaluated prospectively. Seventy patients aged >18 yrs with PPE (36 complicated and 34 noncomplicated) were studied after admission to a tertiary referral teaching hospital. MPO concentration was measured in plasma and pleural fluid using a double-antibody competitive radioimmunoassay. The concentrations of MPO in complicated and noncomplicated PPE were compared using a Mann-Whitney U-test and multiple logistic regression models were used to predict the odds that an effusion was complicated. MPO pleural-fluid concentrations were significantly higher in complicated than in noncomplicated PPE. After excluding purulent effusions, pleural-fluid MPO was the marker that best differentiated between the two types of PPE: the area under the receiver operating characteristic curve was 0.912, the sensitivity was 87.5% and the specificity was 85.1% at a cut-point limit of 3.000 microg x L(-1). The authors concluded that the concentration of pleural-fluid myeloperoxidase helps to differentiate between nonpurulent complicated and noncomplicated parapneumonic pleural effusions.
Prevalence of Cholelithiasis According to Alcoholic Liver Disease: A Possible Role of Apolipoproteins AI and AII (1995)

Moderate alcohol intakes decreases the risk of gallstones; in contrast, the prevalence of gallstones is increased in patients with alcoholic cirrhosis. The aims of this prospective study were to assess the prevalence of cholelithiasis among drinkers according to the histological severity of liver disease, and to estimate the importance of serum apolipoproteins AI and apolipoprotein AII as risk factors for gallstones. Among the 320 drinkers included, 53 patients had cholelithiasis. The prevalence increased (p < 0.0001) from 5% in patients with normal liver (1 of 22) and 6% in patients with steatosis only (3 of 47) to 13% in patients with fibrosis (7 of 54), reaching 27% among patients with biopsy-proven cirrhosis (28 of 103). Among patients with clinically obvious cirrhosis on whom biopsy was not performed mainly because of the severity of liver disease, the prevalence of cholelithiasis reached a maximum of 46% (6 of 13). Among drinkers with nonsevere liver disease, patients with cholelithiasis were older (59 +/- 9 years, mean +/- SD vs. 45 +/- 11, p = 0.003) with lower apolipoprotein AI (118 +/- 37 vs. 163 +/- 45 mg/dl; p = 0.002) and apolipoprotein AII (30 +/- 12 vs. 53 +/- 20 mg/dl; p = 0.0002) in comparison with patients without cholelithiasis. These differences persisted after considering by multiple logistic regression analysis, sex, and ideal body weight. Alcohol consumption during the last 5 years was lower in patients with cholelithiasis (83 g/day) in comparison with patients without cholelithiasis (142 g/day; p = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)
An efficient heterogenized palladium catalyst for N-alkylation of amines and α-alkylation of ketones using alcohols (2015)

Silica supported palladium–NiXantphos complex is an efficient and high turnover heterogeneous catalyst for <italic>N</italic>-alkylation of amines and α-alkylation of ketones using alcohols under neat conditions at 120–140 °C following hydrogen borrowing strategy.
An AC Impedance Study of the Degradation of Porous Nickel Battery Electrodes (1988)

AC impedance spectra of porous nickel battery electrodes were recorded periodically during charge/discharge cycling in concentrated solution at various temperatures. A transmission line model (TLM) was adopted to represent the impedance of the porous electrodes, and various model parameters were adjusted in a curve fitting routine to reproduce the experimental impedances. Degradation processes were deduced from changes in model parameters with electrode cycling time. In developing the TLM, impedance spectra of planar (nonporous) electrodes were used to represent the pore wall and backing plate interfacial impedances. These data were measured over a range of potentials and temperatures, and an equivalent circuit model was adopted to represent the planar electrode data. Cyclic voltammetry was used to study the characteristics of the oxygen evolution reaction on planar nickel electrodes during charging, since oxygen evolution can affect battery electrode charging efficiency and ultimately electrode cycle life if the overpotential for oxygen evolution is sufficiently low. Transmission line modeling results suggest that porous rolled and bonded nickel electrodes undergo restructuring during charge/discharge cycling prior to failure. The average pore length and the number of active pores decreases during cycling, while the average solid phase resistivity increases. The average solution phase resistivity remains relatively constant during cycling, and the total porous electrode impedance is relatively insensitive to the solution/backing plate interfacial impedance.
Evaluation of rear-end collision avoidance technologies based on real world crash data (2015)

Over the last decade, collision avoidance technologies targeting rear-end collisions have been introduced by many vehicle manufacturers. However, evaluation of the real world performance of these systems are rare. The objective of this study was to evaluate the real world effectiveness of systems called Forward Collision Warning and Brake support combined with Adaptive Cruise Control (CWB+ACC). These systems were introduced as optional equipment in Volvo car models in 2006. The data analyzed comes from a detailed, representative dataset based on insurance claims. The rate of rear-end frontal collisions was compared for cars with and without CWB+ACC, controlling for different generations of CWB+ACC as well as presence of Low-speed Emergency Braking functionality. For cars with CWB+ACC, rear-end crashes with frontal impacts were reduced with 38%. Also, the data showed a clear progress in crash avoidance efficiency as a function of CWB+ACC development. For the third generation of CWB+ACC, the estimated collision avoidance effect was 45%. In future studies, the additional safety performance that collision avoidance technologies bring in the form of crash mitigation needs to be investigated.
The Effect of Halothane Anesthesia on Myocardial Necrosis,Hemodynamic Performance, and Regional Myocardial Blood Flow in Dogs Following Coronary Artery Occlusion (1983)

The effect of halothane anesthesia on myocardial necrosis resulting from coronary artery ligation was examined in 28 anesthetized mongrel dogs. In 18 dogs, the left anterior descending coronary artery (LAD) was ligated immediately proximal to the first apical diagonal branch, and 1 h later the dogs were assigned randomly either to receive halothane, 0.5-1.0% inspired in room air for 12 h (n = 10) or to awaken without further intervention (control, n = 8). Infarct size was measured by staining the myocardium with triphenyl tetrazolium chloride 24 h after LAD ligation. Infarct size in halothane-treated dogs was 17.8 +/- 2.0% of the left ventricle, compared with 27.3 +/- 3.3% in control dogs (P less than 0.05). Myocardial salvage was present transmurally but was greatest in epicardial regions. In 10 additional dogs, hemodynamic variables (heart rate, arterial pressure, left ventricular end-diastolic pressure, peak left ventricular dP/dt, tension-time index, and rate-pressure product) were measured or calculated, and radionuclide-labeled microspheres were injected for measurement of cardiac output and regional myocardial blood flow (RMBF). Thirty minutes after LAD ligation and after initial hemodynamic measurements and microsphere injection, these dogs were assigned randomly to receive either halothane, 1.0%, inspired in room air (n = 5) or no intervention (control, n = 5). After 15 min of halothane inhalation (45 min after LAD ligation in control dogs), measurements were repeated. Halothane inhalation reduced heart rate, arterial pressure, and indexes of left ventricular contractile and pump performance. During halothane treatment, RMBF declined in normal myocardium but not in ischemic regions, while neither normal nor ischemic zone RMBF changed in control dogs. Systemic vascular resistance was unchanged in either group. Thus, halothane was associated with a 35% smaller myocardial infarct, transmural myocardial salvage, reduced heart rate, reduced left ventricular contractile and pump performance, reduced RMBF to nonischemic regions, and unchanged RMBF in the ischemic myocardium.
Quantifying Statistical Interdependence, Part III: N > 2 Point Processes (2011)

Stochastic event synchrony (SES) is a recently proposed family of similarity measures. First, “events” are extracted from the given signals; next, one tries to align events across the different time series. The better the alignment, the more similar the N time series are considered to be. The similarity measures quantify the reliability of the events (the fraction of “nonaligned” events) and the timing precision. So far, SES has been developed for pairs of one-dimensional (Part I) and multidimensional (Part II) point processes. In this letter (Part III), SES is extended from pairs of signals to N > 2 signals. The alignment and SES parameters are again determined through statistical inference, more specifically, by alternating two steps: (1) estimating the SES parameters from a given alignment and (2), with the resulting estimates, refining the alignment. The SES parameters are computed by maximum a posteriori (MAP) estimation (step 1), in analogy to the pairwise case. The alignment (step 2) is solved by linear integer programming. In order to test the robustness and reliability of the proposed N-variate SES method, it is first applied to synthetic data. We show that N-variate SES results in more reliable estimates than bivariate SES. Next N-variate SES is applied to two problems in neuroscience: to quantify the firing reliability of Morris-Lecar neurons and to detect anomalies in EEG synchrony of patients with mild cognitive impairment. Those problems were also considered in Parts I and II, respectively. In both cases, the N-variate SES approach yields a more detailed analysis.
The Effect of a Latent Avian Encephalomyelitis Virus Infection in the Chicken Embryo on the Propagation of Newcastle Disease, Influenza, and Infectious Bronchitis Viruses (1968)

Vance J. Yates, Dharam V. Ablashi, Pei W. Chang, The Effect of a Latent Avian Encephalomyelitis Virus Infection in the Chicken Embryo on the Propagation of Newcastle Disease, Influenza, and Infectious Bronchitis Viruses, Avian Diseases, Vol. 12, No. 3 (Aug., 1968), pp. 401-411
Activity Coefficients at Infinite Dilution of Organic Solutes in 1-Ethyl-3-methylimidazolium Tris(pentafluoroethyl)trifluorophosphate [EMIM][FAP] Using Gas−Liquid Chromatography (2010)

The activity coefficients at infinite dilution, γi∞, for both polar and nonpolar solutes in the ionic liquid 1-ethyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate ([EMIM][FAP]) have been determined by gas−liquid chromatography using the ionic liquid as the stationary phase. The measurements were carried out in the temperature range of (313 to 364) K. The partial molar excess enthalpies at infinite dilution HiE,∞ of the solutes in the ionic liquid were also derived from the temperature dependence of the γi∞ values.
P (2013)

We describe the design and implementation of P, a domain-specific language to write asynchronous event driven code. P allows the programmer to specify the system as a collection of interacting state machines, which communicate with each other using events. P unifies modeling and programming into one activity for the programmer. Not only can a P program be compiled into executable code, but it can also be tested using model checking techniques. P allows the programmer to specify the environment, used to "close" the system during testing, as nondeterministic ghost machines. Ghost machines are erased during compilation to executable code; a type system ensures that the erasure is semantics preserving.
Optimization of the frequency response of a semiconductor-optical-amplifier/fiber-Bragg-grating wavelength converter (1998)

Summary form only given. Wavelength converters that employ semiconductor optical amplifiers (SOAs) have a finite frequency response that leads to a pattern-dependent response at high bit rates. We recently showed that filtering the corrupted data with the sharp edge of a fiber-grating filter eliminates pattern dependence. Here, we measure the modulation transfer function of the SOA/fiber-grating device and determine the optimum filtering condition for nonreturn-to-zero data in the small-signal regime.
On the use of Hopkinson bar-bending apparatus to study soft impact on porcine ribs (2012)

"On the use of Hopkinson bar-bending apparatus to study soft impact on porcine ribs." Computer Methods in Biomechanics and Biomedical Engineering, 15(sup1), pp. 311–312Keywords: Polymeric split Hopkinson pressure bar (PSHPB)impact biomechanicsbending testporcine rib Acknowledgements The authors like to express our gratitude to the PARCHOCS project partners: ATCOM, ITC and DGA-Tt for their partnership. We specially thank to Roxan Cayzac, Emmanuel Mennesson and Marc Munier butchery in Bourges.
Flame Temperature Measurements In A Cylindrical Tube Using Holographic Interferometry (1988)

Holographic interferometry was used to measure the instantaneous temperature distribution of a premixed flame propagating through a cylindrical tube. In spite of the crude assumptions employed, the combined inaccuracy and imprecision of the measurements was estimated to be less than ±5 percent. The sources of error, the techniques used to minimize the errors, and the magnitude of the residual errors are described.
Comparison of Crotamiton 10% Cream (Eurax) and Permethrin 5% Cream (Elimite) for the Treatment of Scabies in Children (1990)

Abstract Permethrin 5% cream (Elimite) was approved as a treatment for scabies by the U.S. Food and Drug Administration in September 1989. in a doubie‐biinded, randomized study, it was compared with crotamiton 10% cream (Eurax) for the treatment of scabies in children 2 months to 5 years of age. Two weeks after a singie overnight treatment, 14 (30%) of 47 chiidren were cured with permethrin 5% cream, in contrast to oniy 6 of 47 (13%) of subjects treated with Eurax. Four weeks after treatment the figures were 89% and 60% cured for the two agents, respectively. In 10 of the 19 patients whose treatment failed, the condition became worse after therapy. The difference in efficacy in favor of permethrin was significant (P = 0.002). That agent also demonstrated greater effectiveness in reducing pruritus and secondary bacterial infections. Eilmite offers a safe, efficacious, and cosmetically elegant aiternative to Eurax in the treatment of scabies in chiidren.
Identification of Soil Microbes Capable of Utilizing Cellobiosan (2016)

Approximately 100 million tons of anhydrosugars, such as levoglucosan and cellobiosan, are produced through biomass burning every year. These sugars are also produced through fast pyrolysis, the controlled thermal depolymerization of biomass. While the microbial pathways associated with levoglucosan utilization have been characterized, there is little known about cellobiosan utilization. Here we describe the isolation and characterization of six cellobiosan-utilizing microbes from soil samples. Each of these organisms is capable of using both cellobiosan and levoglucosan as sole carbon source, though both minimal and rich media cellobiosan supported significantly higher biomass production than levoglucosan. Ribosomal sequencing was used to identify the closest reported match for these organisms: Sphingobacterium multivorum, Acinetobacter oleivorans JC3-1, Enterobacter sp SJZ-6, and Microbacterium sps FXJ8.207 and 203 and a fungal species Cryptococcus sp. The commercially-acquired Enterobacter cloacae DSM 16657 showed growth on levoglucosan and cellobiosan, supporting our isolate identification. Analysis of an existing database of 16S rRNA amplicons from Iowa soil samples confirmed the representation of our five bacterial isolates and four previously-reported levoglucosan-utilizing bacterial isolates in other soil samples and provided insight into their population distributions. Phylogenetic analysis of the 16S rRNA and 18S rRNA of strains previously reported to utilize levoglucosan and our newfound isolates showed that the organisms isolated in this study are distinct from previously described anhydrosugar-utilizing microbial species.
Ortho functionalization of aromatic amines: ortho lithiation of N-pivaloylanilines (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrtho functionalization of aromatic amines: ortho lithiation of N-pivaloylanilinesWalter Fuhrer and Heinz W. GschwendCite this: J. Org. Chem. 1979, 44, 7, 1133–1136Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/jo01321a023https://doi.org/10.1021/jo01321a023research-articleACS PublicationsRequest reuse permissionsArticle Views2096Altmetric-Citations134LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase II trial of Ontak to deplete regulatory T cells in treatment-refractory stage III/IV ovarian cancer (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4885 

This Phase II trial tests whether Ontak (denileukin diftitox) is useful to treat epithelial ovarian cancer, stages III or IV that have failed first-line therapy with optimal surgical debulking and platinum-based chemotherapy. Ontak is a fusion toxin consisting of interleukin-2 genetically fused to diphtheria toxin. It is approved to treat cutaneous T cell leukemia/lymphoma. Our recent Phase I trial demonstrated that Ontak depletes human regulatory T cells (Tregs), associated with improved measures of T cell immunity and associated with clinical improvements in ovarian cancer. Based on Phase I results, we initiated a Phase II clinical efficacy trial in treatment-refractory epithelial ovarian cancer using Ontak 12 micrograms/kilogram once monthly. In the Phase II design, patients received no chemotherapy for at least two weeks and no immune or radiation therapy for at least four weeks prior to enrollment. Infusion pretreatment is antihistamines, acetaminophen and anti-emetics, but no steroids. Five patients (FIGO1,2,4-6) have been treated to date. FIGO1 experienced CA-125 stabilization and approximately 20% reduction in her pelvic mass after two cycles, but was then withdrawn for hypoalbuminemia. FIGO2 experienced CA-125 stabilization after two cycles. FIGO4 experienced a 20% drop in CA-125 after two cycles, but then progressed. FIGO5 progressed after one cycle. Immune analyzes are currently incomplete post-Katrina. Existing data confirm that Ontak treatment in the Phase II trial is associated with reductions in phenotypic CD4+CD25hi blood Tregs and increased CD3+IFN-g+ T cells consistent with our Phase I results. Studies of Treg function, T cell cytokine production and CD4+CD25+ T cell FOXP3 content will be undertaken shortly when full laboratory operations resume using saved clinical material. The trial continues to accrue patients. These data suggest that Ontak depletes Tregs in ovarian cancer. The link between Treg depletion and any observed immune changes or clinical effects is under active investigation, and remains to be determined.
Energetic charged particle spectrometer for the Space Environment Reliability Verification Integrated System (SERVIS-1) satellite (2005)

We present the design and results from a new radiation sensor, the Light Particle Detector, designed specifically to quantify the orbital environment responsible for microelectronics damage. It supports Japan's Space Environment Reliability Verification Integrated System.
Layer-by-layer self-assembled thin films of chitin fibers and heparin with anti-thrombus characteristics (2015)

Layer-by-layer assembled films of chitin nanofibers and heparin with anti-thrombus characteristics.
Peter Safar: 12 April 1924 – 03 August 2003 (2005)

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