gebhart/patrepeval huggingface dataset:
Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers (2002)

Chronic or non-healing lower extremity ulcerations in diabetics are a significant cause of morbidity and mortality, and account for a large proportion of the financial burden related to the care of diabetics. Lower extremity ulcerations develop primarily as a consequence of neuropathy and the goal in addressing any wound is to re-establish tissue integrity as soon as possible. The healing of wounds is a complex procedure involving multiple growth factors, some of which have multiple effects on different cell types, in particular, platelet derived growth factor (PDGF) is a prominent agent, active in all stages of the healing process. Becaplermin (0.01% Regranex gel) is a homodimeric protein produced by recombinant DNA technology through the insertion of the gene for the B chain PDGF into the yeast Saccharomyces cerevisiae. The biological activity of becaplermin is similar to that of indigenous PDGF-BB, specifically, the promotion of chemotactic recruitment and the proliferation of cells involved in wound repair. Becaplermin has undergone extensive animal and human studies, demonstrating that it is highly effective as an adjunctive measure for the healing of ulcerations in the feet of diabetics when used in conjunction with standard wound healing practices. Specifically these practices include the provision of a moist environment free of debris and necrotic tissue, control of infection and optimal weight displacement from the affected area. Becaplermin is safe and easy to use, being applied once-daily and at present, becaplermin is the only growth factor licensed for use in wound healing.
Electrochemical Synthesis of p-Type CuFeO<sub>2</sub> Electrodes for Use in a Photoelectrochemical Cell (2012)

A new electrodeposition route was developed to prepare p-type CuFeO2 as a thin film-type electrode for use as a photocathode in a solar water splitting cell. The resulting p-CuFeO2 film has a bandgap energy of ca. 1.55 eV, with its conduction band edge located at a more negative potential than the reduction potential of water. Various photoelectrochemical properties of the p-CuFeO2 electrode were investigated, and its photoelectrochemical hydrogen production in 1 M NaOH solution was confirmed by gas chromatography. The incident photon-to-current conversion efficiency plot confirmed that p-CuFeO2 has the ability to utilize the entire range of visible light.
Isotopically Nonstationary MFA (INST-MFA) of Autotrophic Metabolism (2013)

Metabolic flux analysis (MFA) is a powerful approach for quantifying plant central carbon metabolism based upon a combination of extracellular flux measurements and intracellular isotope labeling measurements. In this chapter, we present the method of isotopically nonstationary (13)C MFA (INST-MFA), which is applicable to autotrophic systems that are at metabolic steady state but are sampled during the transient period prior to achieving isotopic steady state following the introduction of (13)CO2. We describe protocols for performing the necessary isotope labeling experiments, sample collection and quenching, nonaqueous fractionation and extraction of intracellular metabolites, and mass spectrometry (MS) analysis of metabolite labeling. We also outline the steps required to perform computational flux estimation using INST-MFA. By combining several recently developed experimental and computational techniques, INST-MFA provides an important new platform for mapping carbon fluxes that is especially applicable to autotrophic organisms, which are not amenable to steady-state (13)C MFA experiments.
PMM.82 Experience with a novel intravenous iron preparation - Monofer in pregnant women with iron deficiency anaemia (2014)

Introduction Monofer is a novel parenteral iron preparation with little free iron toxicity and low immunological potential. It can be given as a single total dose by intravenous infusion over a short time without the need for test dose. It has potential cost benefits along with user convenience and dosing flexibility leading to patient satisfaction. Aims/objectives To determine the compliance with guidelines and to examine the efficacy and safety of monofer. Methods Retrospective audit of the case notes over a period of 18 months between May 2012 to December 2013. Audit Standards Local trust guideline and “UK national guidelines (British Committee for standards in Haematology 2011)”. Results Total 50 patients were identified, 46 patients were included in the analyses. The standards were met in all 46 patients. Mean pre-infusion Haemoglobin was 76 (range 61–97) and mean pre-infusion ferritin was 7 (rang 1–25). Of the 46 patients who received monofer, none had severe reactions. 7(15%) had minor adverse reactions including chest and back discomfort and one developed severe bronchospasm within 5 min of commencement which led to the discontinuation of the infusion. Mean hospital stay was 7 h (range 3–48 h). Mean Haemoglobin post monofer infusion at 3–5 weeks interval was 85 (83–119). No delayed reactions were observed and none required blood transfusion. Conclusion Monofer is safe and effective single dose preparation. It is well tolerated with a favourable safety profile. It reduces the blood transfusion rates, is cost effective and improves patient satisfaction. It can be given in the day case setting. Reference Pavord S, Myers B, Robinson S, Allard S, Strong J, Oppenheimer C. UK guidelines on the management of iron deficiency in pregnancy. British Journal of Haematology 2012;156(5):588–600
Unraveling DNA Repair in Human: Molecular Mechanisms and Consequences of Repair Defect (2001)

Cellular genomes are vulnerable to an array of DNA-damaging agents, of both endogenous and environmental origin. Such damage occurs at a frequency too high to be compatible with life. As a result cell death and tissue degeneration, aging and cancer are caused. To avoid this and in order for the genome to be reproduced, these damages must be corrected efficiently by DNA repair mechanisms. Eukaryotic cells have multiple mechanisms for the repair of damaged DNA. These repair systems in humans protect the genome by repairing modified bases, DNA adducts, crosslinks and double-strand breaks. The lesions in DNA are eliminated by mechanisms such as direct reversal, base excision and nucleotide excision. The base excision repair eliminates single damaged-base residues by the action of specialized DNA glycosylases and AP endonucleases. Nucleotide excision repair excises damage within oligomers that are 25 to 32 nucleotides long. This repair utilizes many proteins to remove the major UV-induced photoproducts from DNA, as well as other types of modified nucleotides. Different DNA polymerases and ligases are utilized to complete the separate pathways. The double-strand breaks in DNA are repaired by mechanisms that involve DNA protein kinase and recombination proteins. The defect in one of the repair protein results in three rare recessive syndromes: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. This review describes the biochemistry of various repair processes and summarizes the clinical features and molecular mechanisms underlying these disorders.
A Babylonian Tablet with an Aramaic Endorsement (1937)

The cuneiform tablet here edited belongs to the Museum of Natural History at Torquay, and I am greatly indebted to the Curator who has kindly submitted it to me for study and publication. Whence it comes is unfortunately unknown, but it seems to be of the same class as the large number of commercial documents from Nippur in middle Babylonia which now belong to the University of Pennsylvania and have been published in four volumes by the late Professor A. T. Clay. This suggestion is made especially probable by the Aramaic endorsement or summary of the Babylonian text which closely resembles those found on some of the tablets in that collection. It appears to be the only one of its class in England, so far as published collections go, since the tablets in the British Museum which bear Aramaic notes are Assyrian texts of the seventh century B.C.
Interação Molecular entre Alfa-Ciclodextrina e Triptofano (2008)

O objetivo deste trabalho foi determinar a constante de formacao do complexo de inclusao entre a alfa-ciclodextrina e o aminoacido triptofano. Para a determinacao da constante de inclusao, foi utilizado o metodo competitivo do alaranjado de metila. O triptofano realiza interacoes moleculares com a alfa-ciclodextrina com constante de inclusao de 36,16 M-1. Estes resultados embasam o desenvolvimento de trabalhos de entrega metabolica de triptofano e a reducao de gostos indesejados de proteinas hidrolisadas utilizadas na alimentacao animal.
Measurement based intelligent prefetch and cache technique in Web (2003)

In Web users in the same workgroup might have similar interests and habits. In this paper we study intelligent proxy techniques for people who use a proxy to access Web. Our intelligent proxy has two parts: cache and prefetch. We researched three replacement policies for proxy cache: LRU and two variations of LRU. Our simulation showed that basic LRU produces worst hit rate, while the other two policies achieve roughly the same results. Therefore, we choose a mixture of them as our proposed scheme. By introducing the prediction algorithm and threshold algorithm. The proxy can predict which Web files will be needed in the near future and download some of them before they are really requested by the user group. We can get a more accurate probability by running it on the proxy server than on the client site, when client user has not visited a file in a Web server often enough. By implementing the techniques of prefetch and cache on the proxy server, we can reduce the Web latency perceived by users and also the total number of access requests to Web server, thus propose a reasonable way of decreasing their cost to access the Web for developing countries.
Effects of physical exercise on colonic motor activity (1991)

We investigated the effect of physical exercise on colonic motor activity in the fasted and fed states in six conscious dogs. Each dog was implanted with nine strain gauge transducers: three on the proximal, three on the middle, and three on the distal colon. The dogs ran for 1 h on a treadmill at 5 km/h (slope 5%). In the fasted state, the dogs exercised during the 5th h of recording after an overnight fast, and in the fed state during the 1st, 3rd, and 5th postprandial hour. In the fasted state, exercise significantly decreased the frequency of colonic migrating motor complexes (MMCs) but had no effect on the total or the mean duration of contractile states in the proximal, middle, and distal colon. Postprandially, exercise disrupted colonic MMCs and replaced them with nonmigrating motor complexes in all three periods of exercise (1st, 3rd, and 6th h). Exercise also increased the total duration per hour of contractile activity throughout the colon during the 1st and 3rd h and only in the distal colon during the 6th h after the meal. The dogs never defecated during rest in the fasted or the fed state. Shortly after the start of exercise in the fasted and fed states, giant migrating contractions (GMCs) occurred, and they were followed by defecation. In approximately 40% of the experiments, another GMC originated in the proximal colon, approximately 10 min after the first defecation, and migrated caudad up to the middle colon. These GMCs were not associated with defecation but caused mass movements.(ABSTRACT TRUNCATED AT 250 WORDS)
[Human thrombin: enzymatic properties, stability and standardization of preparation]. (2003)

The work deals with estimation of thrombin preparation having such features as: sedimentation activity 3000-3200 NIH un. per 1 mg of protein and 97% of active centres. The enzyme isolated has been estimated according to the amidolytic activity on synthetic substrates S-2160 and BAPNA being equal 5200 and 185 milli un/mg of protein, respectively. According to the electrophoresis in PAAG in the presence of Ds-Na the preparation is homogenous, its molecular mass is 36000. The fibrinogen sedimentation time dependence on the isolated thrombin concentration has been estimated as well as the comparative analysis with the thrombin of the firm "Sigma" with the previously calibrated activity using the international standartion (coded P4) has been conducted. The absence of proportionality between the substrate sedimentation time and the preparation concentration has been determined. It has been revealed, that if the experimental findings are presented in the units 1/t against the thrombin units NIH the right lines are received within the limits used. The defreezing and secondary freezing of the preparation preserved under -20 degrees C have been showed as rendering an essential effect on thrombin activity. In order of the enzyme stabilizing at preserving the thrombin isolated has been concentrated applying the amycon membranes (MWCo: 30,000). While applying the thrombin water-saline solution in the conditions selected the preparation has showed itself practically stable during a year without utilizing any admixtures. The essential effect on thrombin has been found from the side of 1% glycin, 0.5% PEG, 1% saccharose and so on. The thrombin isolated high functional homogeneity, its stability permit to recommend the preparation as an operative standard.
Evaluation of Ferroelectric Materials for Memory Applications (1990)

Ferroelectric materials have wide application in area such as piezoelectric transducers, pyroelectric detectors, and electro-optics, and now thin-film ferroelectric materials are being integrated with conventional semiconductor processes to produce memory devices. Memories based on this technology potentially offer nonvolatile data storage and extended read-write endurance in comparison with EEPROMs, without speed or power penalties. These memories are also radiation hard. Considerable interest in ferroelectric memory exists in the Department of Defense (DOD) because of these characteristics. However, several problems remain unsolved and no memory devices have been produced as yet. The physical mechanisms (as they are understood) are discussed, the claims made for the technology are examined, and the potential roadblocks, such as: cycle dependent fatigue, time dependent degradation of memory retention, and fabrication problems are evaluated.
Industry Targeting: A New Approach to Local Economic Development (1994)

Industrial policy; Illinois
Modular neural system, based on a fuzzy clustering network, for classification (2002)

Deals with the application of a modular neural network system to the classification of poor, low dimensional remote sensed data. The main objective is the reduction of the computational complexity of the neural learning stage, which is influenced by the characteristics of the training data. The classification task is decomposed in two phases. In the first phase, a fuzzy Kohonen network module is used for organizing training patterns into clusters. In the second phase, a feedforward network based on the backpropagation rule, is employed for labelling the clusters obtained in the first phase. The attention is focused on the effectiveness of the fuzzy network module, in applications where clusters touch or overlap. The performance of the modular system have been evaluated in comparison with those of a multilayer perceptron network (MLP). Experimental results have confirmed that the modular network system, supported by the fuzzy clustering module, improves the classification accuracy compared to the results obtained by the supervised MLP alone.
Current concepts of cell kinetics in the treatment of leukemia. (1975)

In a relatively brief time, considerable information has been accumulated concerning the relationship of the cell proliferation characteristics of acute leukemia and response to chemotherapy. Much remains to be learned, but we are now able to approach the problem of therapeutic regimen design based on observed patterns of in vivo cell response.
Selective toxicity of N,N'-thiodicarbamates (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective toxicity of N,N'-thiodicarbamatesMohamed A. H. Fahmy, N. Moorthy Mallipudi, and T. Roy FukutoCite this: J. Agric. Food Chem. 1978, 26, 3, 550–557Publication Date (Print):May 1, 1978Publication History Published online1 May 2002Published inissue 1 May 1978https://pubs.acs.org/doi/10.1021/jf60217a021https://doi.org/10.1021/jf60217a021research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
복합운동 트레이닝 유형이 중년여성의 건강체력과 신체구성 및 대사증후군 지표에 미치는 영향 (2009)

The purpose of this study was to investigated the effects of the combined exercise training on body composition, health-related fitness, and metabolic syndrome parameters in middle aged women. The subjects were 43 who were divided into aerobic-resistance combined group(n=13), aerobic-stretching combined group (n=12), and control group(n=18) according to the presence of the exercise training. The two combined exercise group participated in 60minutes of walking exercise(20min)-thera band exercise(40min) and walking exercis (40min)-stretching (20min) three days a week for 12 weeks. The results analyzed by two-way ANOVA with repeated measures were as follows; 1) body weight, fat weight, %body fat, waist-hip ratio, and BMI decreased significantly and lean body mass increased significantly in two combined exercise groups, whereas control group did not change significantly. 2) grip strength, back strength, and sit-up increased significantly in aerobic-stretching combined group and maximal oxygen uptake and sit & reach increased significantly in two combined exercise groups, whereas no changes in control group. 3) waist circumference, glucose, TC, LDL-C decreased significantly and HDL-C increased significantly in two combined exercise groups, while systolic blood pressure and TG decreased significantly in aerobic-stretching combined group, whereas no changes in control group. In summary, it suggested that combined exercise program has positive effect on body composition, health-related fitness, and metabolic syndrome parameters. Finally, there was an indication that combined group of aerobic exercise type may be better than combined group of resistance exercise type for improving fat loss and metabolic syndrome.
THE D2B OPTICAL BUS - AN INTEGRATION PLATFORM FOR CAR ENTERTAINMENT AND TELEMATIC SYSTEMS (1997)

Integration of telematic platforms in vehicles means adaptation of already installed electric and electronic components. Along with different sensor systems like crash detection or speed metering, the connection to wireless communication and car entertainment systems is a basic need. The D2B optical bus offers the integration of those systems in an efficient way and satisfies the needs for a noiseless and flexible in-vehicle communication as well as the needs for a flexible system design. Customer's value can be saved by modularity and a possible system extension not only in the after sales market but also in OEM solutions. For reaching this aim a strong commitment to standardization up to the application level is necessary. For the covering abstract, see IRRD 490001.RRD 490001.
Large-scale ordered macroporous SiO2 thin films by a template-directed method (2002)

Ordered three-dimensional macroporous SiO2 films were fabricated by colloidal crystal templating. Scanning electron microscope measurements showed that the size of the air sphere replicates that of the initial polystyrene spheres, and that the porous sample exhibits long-range order. Optical measurements show that the macroporous sample exhibits the behavior of a photonic band gap, indicating crystalline order in the sample. Fourier-transform infrared measurements revealed that a strong network of Si–O–Si bonds have been formed throughout the voids of the template before the solidification of the gel. It is proposed that this network hinders the large volume shrinkage during the subsequent heat treatment, and thus high-quality large-scale ordered macroporous films can be obtained.
Risks of Alternate-Day Prednisone in Patients With Cystic Fibrosis (1991)

In recent years an immune-mediated inflammatory process has been implicated in the genesis of the pulmonary damage seen in patients with cystic fibrosis.1,2 A 4-year double-blind, placebo-controlled trial of alternate-day prednisone (2 mg/kg) was conducted in 45 cystic fibrosis patients with mild-to-moderate pulmonary disease to assess the effect of this drug on the pulmonary inflammatory process.3 The patients in the prednisone group showed better growth and pulmonary function and less morbidity compared with those in the placebo group. No complications were reported among the prednisone-treated patients. To extend these observations, the United States Cystic Fibrosis Foundation sponsored a multicenter double-blind, placebo-controlled trial of alternate-day prednisone. Since March 1986, 283 patients with cystic fibrosis, followed up at 15 centers in the United States and Canada, have been enrolled in this trial. Patients 5 through 14 years of age with mild-to-moderate pulmonary disease were randomly assigned to receive prednisone 2 mg/kg (high-dose) every other day, prednisone 1 mg/kg (low-dose) every other day, or placebo. On entry into the study, patients in the three groups were closely matched by a variety of clinical and laboratory parameters (Table 1). Patients are closely monitored at 3-month intervals for both efficacy and side effects. An interim analysis is carried out every 6 months and the results are reviewed by an unblinded study ombudsman. Initially, 95 patients were randomly assigned to the high-dose group, 94 to the low-dose group, and 94 to the placebo group. At the time of the most recent interim analysis, mean duration in the study was 33.9 months for the high-dose group, 35.3 months for the low-dose group, and 36.8 months for the placebo group.
Mining company directors : in the line of fire : company law (2014)

In the Blue Platinum case, the court delivered a ground-breaking and precedent setting judgement. This judgement highlighted the importance of accountability and environmental responsibility among corporates and has brought to our attention the far-reaching powers of regulatory authorities to hold company directors liable, in their personal capacities, for environmental offences.
Playing the Town Halls (2002)

Urban performances were a staple part of most players’ tours and an important money-spinner. The inhabitants of England’s regional towns and cities provided ready audiences and ‘purses’; and performances by visiting troupes were sponsored in many provincial communities by the local corporation (or ruling civic body) as well. Such productions might be staged within the mayor’s house, but the more usual venue for civic-funded performances appears to have been the town hall or its equivalent.2 Players sometimes used or hired civic halls for self-financed performances as well. At Linton (Cambridgeshire), players paid to use the Town House several times in the Elizabethan period, while in Bath the Queen’s players paid for the use of the Town Hall in 1616–17.3