gebhart/patrepeval huggingface dataset:
Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner (2013)

Cell cycle dysregulation leads to abnormal proliferation and cell death in a context-specific manner. Cell cycle progression driven via the Rb pathway forces neurons to undergo S-phase, resulting in cell death associated with the progression of neuronal degeneration. Nevertheless, some Rb- and Rb family (Rb, p107 and p130)-deficient differentiating neurons can proliferate and form tumors. Here, we found in mouse that differentiating cerebral cortical excitatory neurons underwent S-phase progression but not cell division after acute Rb family inactivation in differentiating neurons. However, the differentiating neurons underwent cell division and proliferated when Rb family members were inactivated in cortical progenitors. Differentiating neurons generated from Rb(-/-); p107(-/-); p130(-/-) (Rb-TKO) progenitors, but not acutely inactivated Rb-TKO differentiating neurons, activated the DNA double-strand break (DSB) repair pathway without increasing trimethylation at lysine 20 of histone H4 (H4K20), which has a role in protection against DNA damage. The activation of the DSB repair pathway was essential for the cell division of Rb-TKO differentiating neurons. These results suggest that newly born cortical neurons from progenitors become epigenetically protected from DNA damage and cell division in an Rb family-dependent manner.
A comparison of MIMO-OFDM and MIMO-SCFDE in WLAN environments (2004)

Recent developments in orthogonal frequency division multiplexing (OFDM) and single-carrier frequency-domain equalization (SCFDE) have sparked debate about the superiority of one method over the other. In this paper, we further this debate by comparing the theoretical performance of OFDM and SCFDE when each is implemented in one of two different multiple-input multiple-output (MIMO) architectures: spatial multiplexing and space-time block codes. This study focuses on the use of MIMO-OFDM and MIMO-SCFDE in wireless local area network (WLAN) applications. Performance is given in terms of the packet error rate (PER) and the throughput of the systems.
Data reuse driven energy-aware MPSoC co-synthesis of memory and communication architecture for streaming applications (2006)

The memory subsystem of a complex multiprocessor systems-on-chip (MPSoC) is an important contributor to the chip power consumption. The selection of memory architecture, as well as of communication architecture, both affect the power efficiency of the design. In this paper we propose a novel approach that enables energy-aware co-synthesis of both memory and communication architecture for streaming applications. As opposed to earlier techniques, we employ a powerful compile-time analysis of memory access behavior that adds flexibility in selecting memory architectures. Additionally, we target TDMA bus-based communication architectures, which not only guarantee performance, but also greatly reduce the design time and allow us to find the energy optimal system configuration. We propose and compare three techniques: an optimal mixed ILP-based co-synthesis technique, a mixed ILP-based traditional two-step synthesis approach where memory and communication synthesis is performed sequentially, and a co-synthesis heuristic that synthesizes energy-efficient hierarchical bus-based communication architectures with guaranteed throughput. Our experimental results on a number of streaming applications show that both the traditional two-step synthesis approach and heuristic result in up to 50% worse power consumption in comparison with proposed co-synthesis approach. However, on some of the streaming benchmarks, our co-synthesis heuristic approach was able to find optimal or near-optimal results in a much shorter time than the MILP co-synthesis approach.
Use of Immobilized Platelet Membrane Glycoproteins for the Detection of Platelet‐Specific Alloantibodies in Solid‐Phase ELISA<sup>1</sup> (1987)

Platelet membrane glycoproteins were isolated from intact platelets by detergent-phase extraction, fixed to the wells of microtiter trays and used as targets for the detection of platelet-reactive alloantibodies by enzymelinked immunospecific assay (ELISA). The final preparations contained 0.4% of total platelet protein. Antibodies reactive with antigens PlA1, PlA2, Baka, Pena and HLA-A2 were specifically detected at dilutions ranging form 1:640 to 1:1.600. Under the conditions utilized, the ELISA was more sensitive than assays involving 51Cr, radiolabeled monoclonal anti-IgG binding, and indirect immunofluorescence testing by one order of magnitude or greater. When platelets were pretreated with chloroquine to remove class I HLA antigens prior to detergent-phase extraction, reactions with HLA-specific antibodies were lost, but reactions with platelet-specific alloantibodies were retained. This approach offers a simple, sensitive and rapid method to detect and identify platelet-specific alloantibodies in sera containing HLA-reactive alloantibodies.
Evanescent-Wave Spectroscopy on Bulk-Response Optode Membranes (1992)

The absorbance of a solvent polymerie bulk optode membrane in contact with sapphire as a wave-guide is studied with the attenuated total reflection (ATR) technique. Utilizing thin (≤ 1 μm) and, therefore, fast-responding membranes, high values of absorbance are obtained by multiple internal reflection (MIR). The approach has an advantage over conventional transmission studies in that the light beam does not pass through the sample solution. Samp1e-induced swelling of the membrane may, however, create problems.
Practical DC Drive Circuitry for LEDs (2011)

LEDs need to be electrically driven in order to emit light. This chapter discusses how to design DC drive circuitry for LEDs. The fundamental determinant of what type of converter to use for a DC drive is set by the relative values of the supply voltage and the LED voltage. The chapter provides some basic information of batteries and also examines the performance of the batteries. The most basic piece of electrical information about a cell or battery is that it is a voltage source. Cells are actually complicated electrochemical systems. A buck converter can convert an input voltage to a lower output voltage. Switch‐mode power supplies (SMPS) are used almost universally to convert a source of power into a form suitable for a load. The chapter covers some of the basics of the topologies that will be suitable for driving LEDs from DC sources.
Prevention and Control of Sulphate Scaling in the Namorado Field, Campos Basin, Brazil (1996)

Abstract Precipitation inhibitor squeeze treatments have been performed in the last 5 years in the Namorado field to avoid barium sulphate and strontium sulphate scaling in the producing tubing. This paper describes the laboratory tests conducted to select inhibitor and to simulate the squeeze operation in porous media. Based on these tests a polyacrylic acid product was used in the squeeze operations. The squeeze operation design is described as well as the strategy for analytical monitoring of the produced waters to select the wells with high precipitation potential for the prevention treatment. This paper describes the occurrence of spherical precipitated material (with morphology similar to ooids formed in natural enviroments) at the bottom of the well NA-C. The analysis of the ooids, associated with the production parameters, allowed the determination of the effectiveness of the squeeze treatment and the understanding of the precipitation mechanisms.
The Relationship between Change of Cardiac Function and Systemic Oxygen Consumption according to the Dose of Dopamine in the Rabbit (2001)

Purpose : We'd like to know the relationship between the changes of cardiac function and systemic O2 consumption according to the increasing dose of dopamine. Methods : Ten rabbits(from 2kg to 2.8kg) were used in this experiment. Anesthesia was induced with intraperitoneal pentobarbital sodium(35mg/kg) and tracheostomy was done. It was maintained by ventilation with a mixture of 1-3% halothane and 67-69% oxygen. Polyvinyl catheters were inserted into the femoral artery and vein and to check blood pressure and arterial blood gas analysis during the surgical procedure. Two other catheters were inserted into the internal carotid artery and external jugular vein and advanced into left ventricle and right atrium to check the pressure of each chamber, LV maximal dP/dt and to obtain blood samples of each chamber. Thoracotomy was done to expose aorta and coronary artery to check the cardiac output and coronary blood flow. We injected dopamine every 10 minutes according to the scheduled dose through external jugular vein and recorded heart rate, cardiac output, aortic pressure, maximal dP/dt, coronary blood flow by computer. Systemic O2 consumption was calculated by Fick method Results : The heart rate and mean aortic pressure increased slowly according to the dose of dopamine from 20μg/kg/min. The cardiac otuput the maximal dP/dt and coronary blood flow was not changed until 5μg/kg/min, but from 7.5μg/kg/min, it increased according to the dose of dopamine. Conclusion : Dopamine was a powerful inotrophic agent without increasing the systemic O2 consumption until 20μg/kg/min, but systemic O2 consumption increased markedly at more than 20 μ g/kg/min of dopamine. (J Korean Pediatr Soc 2001;44:177-184)
The Lunar Lander ‘HabiTank’ Concept (2007)

<div class="htmlview paragraph">This paper will summarize the study that was conducted under the auspices of the National Aeronautics and Space Administration (NASA), lead by Johnson Space Center's Engineering Directorate in support of the Lunar Lander Preparatory Study (LLPS) as sponsored by the Constellation Program Office (CxPO), Advanced Projects Office (APO). The lunar lander conceptual design and analysis is intended to provide an understanding of requirements for human space exploration of the Moon using the Advanced Projects Office Pre-Lander Project Office selected “HabiTank” Lander concept. In addition, these analyses help identify system “drivers,” or significant sources of cost, performance, risk, and schedule variation along with areas needing technology development. Recommendations, results, and conclusions in this paper do not reflect NASA policy or programmatic decisions. This paper is an executive summary of this study. The detailed technical lander concept report is documented in the ‘<b>Lunar “HabiTank” Lander Element Conceptual Design Report,’</b> JSC-63600 (in process of being released).</div>
Improved C–V characteristics of metal-oxide-semiconductor capacitors with tantalum nitride gate electrodes grown by ultra-low-pressure chemical vapor deposition (2004)

Tantalum nitride (TaN) films have been grown for metal gate electrode applications by ultra-low-pressure chemical vapor deposition using a Ta[=NC(CH3)2C2H5][N(CH3)2]3 precursor. TaN films deposited at 450 °C had a resistivity of 4 mΩ cm. The Ta:N:C ratio of the deposited films was about 1:1:1, as measured by Rutherford backscattering spectroscopy. TaN/SiO2/p-Si capacitors subjected to postdeposition annealing (PDA) showed distorted capacitance–voltage (C–V) curves, although no apparent reaction layer was observed at the interface between TaN and SiO2. The distortion of the C–V curves could be eliminated by depositing a 200-nm-thick SiO2 capping layer onto the TaN gate electrodes prior to PDA. The PDA-induced distortion can be ascribed to mechanical stress due to the difference in thermal expansion coefficients between TaN and Si. It is suggested that control of the mechanical stress during PDA is important for scaled metal-oxide-semiconductor devices using metal gate electrodes.
InP-HEMT MMICs for passive millimeter-wave imaging sensors (2008)

This paper describes InP-HEMT MMICs for 94 GHz band passive millimeter-wave (PMMW) imaging sensors. In order to obtain high sensitivity with a single MMIC, we developed a new structure in MMIC to suppress unwanted feedback power that causes amplifier instability. The structure is also suited for flip chip bonding (FCB). The measured sensitivity of the MMIC was over 500,000 V/W at the frequency of 94 GHz. We also developed the RF front-end of the PMMW imager by mounting the MMIC on an antenna substrate by FCB assembly. In addition, we demonstrated examples of a millimeter-wave image acquired by the PMMW imager.
Uncertain what uncertainty monitoring monitors (2003)

Smith et al. present a model that they suggest may clarify aspects of the phylogenetic distribution of metacognition, based on observation of what they call uncertainty monitoring. Although they suggest that their model is supported by data collected using monkeys and dolphins, their interpretation that nonhuman animal behaviors parallel thought processes in humans may be unwarranted. The model presented by Smith et al. is inconsistent with current theories and empirical findings on the comparative aspects of metacognition. We present three oversights of the model and extend our critique to include a brief discussion of animal self-awareness, as well as current neuropsychological perspectives on metacognitive processing in humans.
Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress. (2001)

Apurinic/apyrimidinic endonuclease is a key enzyme in the process of base excision repair, required for the repair of spontaneous base damage that arises as a result of oxidative damage to DNA. In mice, this endonuclease is coded by the Apex gene, disruption of which is incompatible with embryonic life. Here we confirm the embryonic lethality of Apex-null mice and report the phenotypic characterization of mice that are heterozygous mutants for the Apex gene (Apex+/-). We show that Apex heterozygous mutant cells and animals are abnormally sensitive to increased oxidative stress. Additionally, such animals manifest elevated levels of oxidative stress markers in serum, and we show that dietary supplementation with antioxidants restores these to normal levels. Apex+/- embryos and pups manifest reduced survival that can also be partially rescued by dietary supplementation with antioxidants. These results are consistent with a proposed role for this enzyme in protection against the deleterious effects of oxidative stress and raise the possibility that humans with heterozygous mutations in the homologous HAP1 gene may be at increased risk for the phenotypic consequences of oxidative stress in cells.
Stress and Bronchodilator Response in Children with Asthma (2015)

High child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced BDR in children with asthma. This is likely caused by down-regulation of ADRB2 in highly stressed children.
Suppression of the Chemically Transformed Phenotype of BHK Cells by a Human cDNA (1991)

Transformation of the baby hamster kidney cell line BHK SN-10 by chemical carcinogens such as nitrosylmethylurea (NMU) is mediated by the loss of a gene product critical for the suppression of malignant transformation. Somatic cell hybrids between chemically transformed BHK SN-10 cells and either normal hamster kidney or human fibroblast cells are nontransformed; therefore, a recessive mechanism underlies the malignant transformation of BHK SN-10 cells after chemical carcinogenesis (A. Stoler and N. P. Bouck, Proc. Natl. Acad. Sci. USA 82:570-574, 1985). A human fibroblast cDNA library was constructed and introduced into NMU-transformed BHK SN-10 cells (NMU 34m) in order to identify a human cDNA capable of suppressing cellular transformation. NMU-transformed BHK cells were analyzed for reversion to an anchorage-dependent normal cellular phenotype after transfection with human cDNA. The human cDNA capable of inducing stable reversion of NMU 34m cells encodes the intermediate filament protein vimentin, which is apparently required for maintenance of the normal phenotype in BHK SN-10 cells.
Water-Rock interaction in the Long Valley Caldera (USA) (2013)

Water-rock interactions within the main thermal aquifer in the Long Valley Caldera are evaluated using water chemistry data from a new suite of samples. The results reflect the impact of increased geothermal production and major CO2 loss, which appears to drive calcite precipitation in the aquifer. The study provides qualitative information on the rates of mineral reactions and the response times of chemical geothermometers to declining temperatures.
Changes in Astigmatism after Suture Removal in Penetrating Keratoplasty (2003)

Purpose : To study a refractive change after suture removal and to evaluate some factors for this change in penetrating keratoplasty. Methods : We studied 53 eyes of 47 patients who had undergone penetrating keratoplasty. Subjective refraction and best corrected visual acuity were measured in all eyes before and after the removal of sutures. We also classified the subject eyes based on suture removal time, degree of astigmatism before suture removal, recipient trephine size and compared the change of astigmatism within the groups. Results : Suture removal decreased the astigmatism by an average of 0.81 diopter (D) (p=0.02) and increased the best corrected visual acuity by an average of 0.17 (p=0.005). These results show that corneal astigmatism tends to decrease more with early suture removal (p=0.010), higher degree of astigmatism before suture removal (p
Effect of catalysts on the reaction of allyl esters with hydrosilanes (2010)

The reaction of hydrosilylation of allyl esters XOCH2CH=CH2 (X = MeCO, CF3CO, C3F7CO) and PhOCH2CH=CH2 with hydrosilanes HSiY3 (Y = Cl, OEt) in the presence of the Speier catalyst, the Speier catalyst with additives, and of various nickel complexes was studied. The catalytic hydrosilylation reaction in the presence of the Speier catalyst is accompanied by the reduction. Additives to the Speier catalyst (vinyltriethoxysilane and some ethers) allow to suppress considerably the reduction reaction. In the presence of the studied nickel complexes mainly reduction and isomerization reactions occurred. The best nickel catalysts of hydrosilylation were the mixtures of NiCl2 or Ni(acac)2 with phosphine oxides. In contrast to allyl esters, the hydrosilylation of simple olefins proceeds easier, the content of the product of hydrosilylation in the reaction mixture reaches 94.3%.
High‐resolution dental magnetic resonance imaging for planning palatal graft surgery—a clinical pilot study (2018)

Palatal masticatory mucosa thickness measured by high-resolution, non-contrast enhanced dental MRI is comparable with that obtained by bone sounding. Dental MRI enables reliable, non-invasive and radiation-free planning of palatal tissue harvesting and can also be used for location of the GPA at 85% of measurement points, which might help reduce complications during surgery.
ChemInform Abstract: Stereoselective Double Alkylation of Ethyl N‐Boc‐pyroglutamate. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
IEEE ICCCN 2007 Chairs Recommended Papers (2007)

Provides an abstract of the presentations and a brief professional biography of the presenters. The complete presentations were not made available for publication as part of the conference proceedings.
Electric Field Effects in Optical and First-Derivative Modulation Spectroscopy (1972)

The large selection of electroreflectance data available in the literature enables surface field effects on optical and first-derivative modulation spectra to be estimated for most materials. A method for doing this is presented.
Selection of Patients with Recurrence of Ventricular Tachyarrhythmias for Electrical Studies (1984)

Clinical cardiac electrophysiologic testing has been employed in the evaluation and treatment of patients with tachyarrhythmias. In patients with recurrent supraventricular tachyarrhythmias, electrophysiologic study is indicated when the arrhythmia is life-threatening or significantly disruptive to lifestyle, when empiric therapy has failed to control the arrhythmia, or when supraventricular tachycardia complicates the Wolff-Parkinson-White syndrome. In patients with ventricular tachyarrhythmias, electrophysiologic study should be undertaken when life-threatening sustained ventricular tachyarrhythmias are documented or when a substantial risk of developing these arrhythmias is noted.
Chemotherapy of Influenza: Current and Novel Approach (2011)

Influenza virus infection attacks huge contingents of the global population in periodic epidemics and pandemics and not rarely is manifested with a severe course, complications and mortality. So far two groups of anti-influenza chemotherapeutics have been licensed and used for prophylaxis and therapy of flu every year—adamantanes (M2 blockers) and neuraminidase inhibitors (NAIs). Since the drug resistance to both groups has been increasing constantly and the risk of flu pandemics still exists, alternative effective inhibitory strategies, like antivirals combinations, should be designed and applied in complicated epidemiological situations with co-circulating influenza subtypes susceptible to different drugs. At the same time discovery of novel antivirals with high activity and selectivity is a matter of great importance and is underway. Both directions will be shortly described in this review.
Hardware/software co-design for high performance computing (2010)

This special session aims to introduce to the hardware/software codesign community challenges and opportunities in designing high performance computing (HPC) systems. Though embedded system design and HPC system design have traditionally been considered as two separate areas of research, they in fact share quite some common features, especially as CMOS devices continue along their scaling trends and the HPC community hits hard power and energy limits. Understanding the similarities and differences between the design practices adopted in the two areas will help bridge the two communities and lead to design tool developments benefiting both communities.
Isomerization reactions occurring on alkylation of benzene with some branched long‐chain 1‐alkenes (1969)

Abstract Benzene was alkylated successively with a mixture of 2‐methyl‐1‐octene and 2‐methyl‐2‐octene, with 2‐butyl‐1‐octene, 3,7‐dimethyl‐1‐octene, 10‐methyl‐1‐undecene and 3,3‐dimethyl‐1‐undecene, using sulfuric acid and aluminium chloride as catalysts. In some cases, a considerable methide shift occurred. With sulfuric acid , there is a considerable preference for the formation of tertiary alkylbenzenes, even if the tertiary carbon atom is far removed from the double bond. Under the conditions used, aluminium chloride shows less preference for the formation of tertiary alkylbenzenes. The yields are low when, in the early stage of the reaction, a tertiary carbonium‐ion type intermediate is formed. Particularly tertiary alkylbenzenes are unstable under alkylation conditions in the presence of aluminium chloride: dealkylation and isomerization to secondary alkylbenzenes occur.