gebhart/patrepeval huggingface dataset:
Regulation of TNF-induced oxygen radical production in human neutrophils: role of δ-PKC (2009)

In human neutrophils, TNF-elicited O(2)(-) production requires adherence and integrin activation. How this cooperative signaling between TNFRs and integrins regulates O(2)(-) generation has yet to be fully elucidated. Previously, we identified delta-PKC as a critical early regulator of TNF signaling in adherent neutrophils. In this study, we demonstrate that inhibition of delta-PKC with a dominant-negative delta-PKC TAT peptide resulted in a significant delay in the onset time of TNF-elicited O(2)(-) generation but had no effect on Vmax, indicating an involvement of delta-PKC in the initiation of O(2)(-) production. In contrast, fMLP-elicited O(2)(-) production in adherent and nonadherent neutrophils was delta-PKC-independent, suggesting differential regulation of O(2)(-) production. An important step in activation of the NADPH oxidase is phosphorylation of the cytosolic p47phox component. In adherent neutrophils, TNF triggered a time-dependent association of delta-PKC with p47phox, which was associated with p47phox phosphorylation, indicating a role for delta-PKC in regulating O(2)(-) production at the level of p47phox. Activation of ERK and p38 MAPK is also required for TNF-elicited O(2)(-) generation. TNF-mediated ERK but not p38 MAPK recruitment to p47phox was delta-PKC-dependent. delta-PKC activity is controlled through serine/threonine phosphorylation, and phosphorylation of delta-PKC (Ser643) and delta-PKC (Thr505) was increased significantly by TNF in adherent cells via a PI3K-dependent process. Thus, signaling for TNF-elicited O(2)(-) generation is regulated by delta-PKC. Adherence-dependent cooperative signaling activates PI3K signaling, delta-PKC phosphorylation, and delta-PKC recruitment to p47phox. delta-PKC activates p47phox by serine phosphorylation or indirectly through control of ERK recruitment to p47phox.
X-ray diffraction study of elemental erbium to<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mn>70</mml:mn><mml:mspace width="0.3em"/><mml:mi>GPa</mml:mi></mml:mrow></mml:math> (2005)

We have investigated phase transitions in elemental erbium in a diamond anvil cell (DAC) up to $70\phantom{\rule{0.3em}{0ex}}\mathrm{GPa}$ using angular-dispersive x-ray powder diffraction methods. We present evidence of a series of phase transitions that appear to follow the anticipated $\mathrm{hcp}\ensuremath{\rightarrow}\mathrm{Sm}\text{\ensuremath{-}}\mathrm{type}\ensuremath{\rightarrow}\mathrm{double}\phantom{\rule{0.3em}{0ex}}\mathrm{hcp}\phantom{\rule{0.3em}{0ex}}(\mathrm{dhcp})\ensuremath{\rightarrow}\mathrm{distorted}$ fcc sequence. In particular, we present evidence for the predicted $\mathrm{dhcp}\ensuremath{\rightarrow}\mathrm{distorted}$ fcc transition above $63\phantom{\rule{0.3em}{0ex}}\mathrm{GPa}$. Equation of state data are also presented up to $70\phantom{\rule{0.3em}{0ex}}\mathrm{GPa}$.
Demonstration of a sol–gel synthesized bifacial CZTS photoelectrochemical cell (2011)

Abstract Cu 2 ZnSnS 4 (CZTS) films grown on transparent conducting electrodes using a sol–gel method were pre‐examined for future bifacial and tandem solar cell applications. Thin film containing Cu–Zn–Sn was prepared by solution based precursor on a SnO 2 ‐F/(FTO) coated glass substrate, which was subsequently annealed in a sulfur environment to obtain a CZTS phase. The photocurrent response of CZTS film was measured using alternating front illumination and rear illumination in a Eu 3+ /Eu 2+ solution environment. The photoelectrochemical response exhibited during rear illumination is comparable to that obtained for front illumination. The promising photocurrent data for CZTS films suggest these films have potential application in semitransparent photovoltaic devices.
Welding Process Development for Spent Nuclear Fuel Canister Repair (2019)

Abstract The potential for stress corrosion cracking (SCC) of welded stainless-steel interim storage containers for spent nuclear fuel (SNF) has been identified as a high priority data gap. This paper presents a fusion welding process that was developed for SNF canister repair. Submerged arc welding (SAW) was developed to weld 12.7 mm (0.5 in.) thick 304L stainless steel plates to simulate the initial welds on SNF canisters. The SAW procedure was qualified following ASME Boiler and Pressure Vessel Code requirements. During SAW, the welding temperature was recorded at various locations by using thermocouples. After SAW, weld microstructures were characterized, joint mechanical properties were tested, and the maximum tensile residual stress direction was identified. After SAW procedure qualification, artificial cracks were excavated perpendicular to the maximum tensile residual stress direction in the SAW heat affected zone. Machine cold-wire gas tungsten arc welding (CW-GTAW) was developed and used for repair welding at cracked locations.
Predicting the Strengths of Angle-Plied Laminates (1982)

Simplified convenient procedure has been developed that can be used to determine elastic and strength properties of angle-plied laminates. Method is suitable for use with pocket calculator. Consists of simple equations and graphs of ply combinations from most frequently used composites. Procedure makes use of well-known transformation equations, ply stress influence coefficients, and ply uniaxial composites including interply and intraply hybrids.
A Comparative Study of Aminosilanes for the Application of Reproducible, Ultralow Detection of Biomolecules (2012)

Abstract not Available.
Implication of cyclooxygenase‐2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia (2003)

Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. We demonstrated that delayed treatment with different classes of COX inhibitor significantly blunted enhancement of dentate gyrus proliferation of neural progenitor cells after ischemia. COX-2 immunoreactivity was observed in both neurons and astrocytes in the dentate gyrus, but not in neural progenitor cells in the subgranular zone. Moreover, in the postischemic dentate gyrus of heterozygous and homozygous COX-2 knockout mice, proliferating bromodeoxyuridine-positive cells were significantly fewer than in wild-type littermates. These results demonstrate that COX-2 is an important modulator in enhancement of proliferation of neural progenitor cells after ischemia.
Metabolism and functions of docosahexaenoic acid‐containing membrane glycerophospholipids (2017)

Omega-3 (ω-3) fatty acids (FAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to have important roles in human health and disease. Besides being utilized as fuel, ω-3 FAs have specific functions based on their structural characteristics. These functions include serving as ligands for several receptors, precursors of lipid mediators, and components of membrane glycerophospholipids (GPLs). Since ω-3 FAs (especially DHA) are highly flexible, the levels of DHA in GPLs may affect membrane biophysical properties such as fluidity, flexibility, and thickness. Here, we summarize some of the cellular mechanisms for incorporating DHA into membrane GPLs and propose biological effects and functions of DHA-containing membranes of several cell and tissue types.
Risk Factors for Candidal Bloodstream Infections in Surgical Intensive Care Unit Patients: The NEMIS Prospective Multicenter Study (2001)

To assess risk factors for development of candidal blood stream infections (CBSIs), a prospective cohort study was performed at 6 sites that involved all patients admitted to the surgical intensive care unit (SICU) for >48 h over a 2-year period. Among 4276 such patients, 42 CBSIs occurred (9.82 CBSIs per 1000 admissions). The overall incidence was 0.98 CBSIs per 1000 patient days and 1.42 per 1000 SICU days with a central venous catheter in place. In multivariate analysis, factors independently associated with increased risk of CBSI included prior surgery (relative risk [RR], 7.3), acute renal failure (RR, 4.2), receipt of parenteral nutrition (RR, 3.6), and, for patients who had undergone surgery, presence of a triple lumen catheter (RR, 5.4). Receipt of an antifungal agent was associated with decreased risk (RR, 0.3). Prospective clinical studies are needed to identify which antifungal agents are most protective and which high-risk patients will benefit from antifungal prophylaxis.
Crystal Structures and Magnetic Behaviors of Cyanido‐Bridged Dinuclear Dimetallic Systems Involving 3d–3d or 3d–5d Metal Centers (2008)

Abstract Three cyanido‐bridged Fe III –Mn II dimers, [Fe(pzcq)(CN) 3 ][Mn(phen) 2 (X)] · MeOH [X = Cl ( 1 ), Br ( 2 ); pzcq = 8‐(pyrazine‐2‐carboxamido)quinoline anion, phen = 1,10‐phenanthroline], [Fe(mpzcq)(CN) 3 ][Mn(phen) 2 (Cl)] · MeOH [ 3 ; mpzcq = 8‐(5‐methylpyrazine‐2‐carboxamido)quinoline anion], and one W V –Mn II dinuclear system, [W(bpy)(CN) 6 ][Mn(phen) 2 (Cl)] · MeOH ( 4 ; bpy = 2,2′‐bipyridine), were prepared by assembling molecular precursors, [Fe(pzcq)(CN) 3 ] – , [Fe(mpzcq)(CN) 3 ] – , and [W(bpy)(CN) 6 ] – , with Mn(phen) 2 X 2 . The absolute configurations of the Mn polyhedra surrounded by two bidentate phen ligands are packed in a –Δ–Λ–Δ–Λ– sequence in the crystal lattice. The aromatic rings of the coordinated phen ligands are sources of considerable interdimer π–π contacts, which eventually lead to the formation of two‐dimensional frameworks ( 1 – 3 ) and a one‐dimensional chain structure ( 4 ). Magnetic analyses of the Fe III –Mn II dinuclear systems ( 1 – 3 ) reveal that a shorter Mn–N(cyanide) bond and a more linear Mn–N–C(cyanide) angle allow for stronger magnetic exchange coupling. Moreover, it is manifested that the 3d–5d magnetic coupling in 4 is stronger than the 3d–3d coupling in 1 – 3 under the given structural environments, which is due to the fact that the 5d orbital is more diffuse than the 3d orbital. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Vergleich der Ausbruchfestigkeit winkelstabiler Plattensysteme bei paralleler und divergierender Schraubenlage (2015)

An oblique screw positioning does not result in a higher tear force in modern plate fixateurs.
The flow of solids (1952)

The present widespread use of polymer plastics has made necessary the study of the mechanical properties of these substances and thus has focussed the interest of the engineer and the physicist once again upon the general problem of the flow properties of solid materials. This is a classical problem; over a period of nearly 100 years it has repeatedly made headlines in physics. The empirical foundations were laid by men whose names mark the development of classical physics—Maxwell, Hopkinson, Kohlrausch. Boltzmann and Wiechert developed a phenomenological, e.g. descriptive, theory which is still unsurpassed. The great Italian mathematician V. Volterra recognized the mathematical implications of this theory and therefrom established the theory of the integral equation that carries his name. The applied physicists and engineers joined forces, bringing with them the tools of modern technology and extending the field of experimental research to a point undreamed of some years ago. And now the theorists of modern physics begin to see a way in which the observed macroscopical behavior of matter may be explained in detail by a satisfactory molecular theory. But in spite of all this combined effort the problem is far from being completely solved.
Reaktionen mit Cyclopentadienonen, XXV<sup>1)</sup> Versuche zur Darstellung von Alkencyclonen (1970)

Abstract Es werden das Styryl‐cyclon 2a , das p ‐Formylphenyl‐cyclon 2c sowie Derivate beschrieben.
STATISTICAL METHODS FOR VERIFYING THE NATURAL LANGUAGE STATIONARITY BASED ON THE FIRST APPROXIMATION. CASE STUDY: PRINTED ROMANIAN (1999)

This paper contains theoretical and experimental results in verifying the hypothesis of printed language stationarity. These results were carried out in the basis of the first approximation to printed Romanian. The statistical approach here-developed enabled the determination of a representative confidence interval for letter probability. The sample which provided this representative interval was further used in the comparison among and between natural texts. Several kinds of statistical inferences have been considered: probability estimation with confidence limits, test of the hypothesis that probability belongs to an interval and test of the difference between two probabilities. The first type statistical error of an α probability as well as the second type statistical error of a β probability have been involved in the quantitative results.
Components, instruments, and techniques for low cost automation and applications : selected papers from the IFAC symposium, Valencia, Spain, 27-29 November 1986 (1988)

(partial) Keynote address. Survey papers. Intelligent instrumentation. Sensors and sensor systems. Instrumentation for robotics. Fault tolerant systems. Control algorithms for microprocessor based systems. Microprocessor-based controllers. Techniques for low cost automation. Process control applications. Automatic control in manufacturing. Control of power systems and electrical drives. Distributed systems. Miscellaneous.
Frequency of the phenylalanine deletion (ΔF<sub>508</sub>) in the CF gene of Belgian cystic fibrosis patients (1991)

Cloning and sequencing of the CF gene has identified a three-base-pair deletion (delta F508) responsible for CF in the majority of CF patients (Kerem et al. 1989). We have used the polymerase chain reaction with oligonucleotide primers bridging the delta F508 deletion to analyze the presence or absence of this mutation in the Belgian CF population. The delta F508 mutation was present in 80% (57 on 71) of CF chromosomes from 36 unrelated Belgian CF families from the region of Antwerp. This mutation was associated with haplotype B for the KM.19-XV-2c RFLPs as 93% (53 on 57) of the CF chromosomes with the delta F508 mutation carried haplotype B.
Design of a Reconfigurable Acoustic Modem for Underwater Sensor Networks (2013)

Design of acoustic modem becomes increasingly important in underwater sensor networks' development. This paper presents the design of a reconfigurable acoustic modem, by defining modulation and demodulation as reconfigurable modules, the proposed modem changes its modulation scheme and data rate to provide reliable and energy efficient communication. The digital system, responsible for signal processing and control, is implemented on Xilinx Virtex5 FPGA. Hardware and software co-verification shows that the modem works correctly and can self-configure to BFSK and BPSK mode. Partial reconfiguration design method improves flexibility of algorithm design, and slice, LUT, register, DSP, RAMB are saved by 17%, 25%, 22%, 25%, 25% respectively.
Fucoidan Modulates the Effect of Transforming Growth Factor (TGF)-.BETA.1 on Fibroblast Proliferation and Wound Repopulation in in Vitro Models of Dermal Wound Repair (2004)

Aberrant wound healing, either causing scarring or chronic wounds, is a significant cause of morbidity. There is therefore, considerable interest in agents which can modulate certain aspects of the wound healing process. Fucoidans, sulphated polyfucose polysaccharides which may be extracted from Fucus spp., have been shown to modulate the effects of a variety of growth factors through mechanisms thought to be similar to the action of heparin. We investigated the interaction between two commercial preparations of fucoidan and transforming growth factor (TGF)-beta(1). These preparations of fucoidan, as well as heparin, inhibited fibroblast proliferation at concentrations from 0.01 to 100 mg/ml. The anti-proliferative effects of 1 ng/ml TGF-beta(1) on dermal fibroblasts were abrogated by fucoidan preparation F7 when used at concentrations over 1 mg/ml. In a three dimensional in vitro model of wound repair, the fibroblast populated collagen lattice or "dermal equivalent", TGF-beta(1) reduced the rate of fibroblast repopulation of a wound defect created by punch biopsy. Addition of fucoidan to the model in the presence of TGF-beta(1) increased the rate of fibroblast repopulation of the wound and at 10 mg/ml of fucoidan the number of cells which had migrated into the wounded defect was similar to that of control cultures. These data suggest that fucoidan has properties which may be beneficial in the treatment of wound healing.
Incorporation of Peptide Isosteres into Enantioselective Peptide-Based Catalysts as Mechanistic Probes (2001)

Olefinic analogues of effective peptide-based catalysts for the kinetic resolution of functionalized racemic secondary alcohols have been synthesized. The isosteric replacement of the peptide amide bond in 1 with an (E)-alkene to form 2 has enabled the evaluation of the kinetic role of particular amides within these catalysts.
Radiation Sensitivity of Human Histiocytic Lymphomas in Vitro (1983)

The radiation sensitivity of five human lymphoma cell lines has been investigated. All cell lines were originated from tumours clinically classified as histiocytic lymphomas. Using biochemical and immunologic techniques it was found that only one of them was a true histiocytic lymphoma. This cell line had an appreciable shoulder on the survival curve and capacity to repair sublethal damage. The survival curves of the other cell lines had no shoulders and the cells had nearly no capacity to repair sublethal damage. Taken together with previously published experimental and clinical observations the results indicate that tumours which by conventional diagnostic techniques are classified as histiocytic lymphomas are very heterogeneous in radiation sensitivity. It is possible that tumours of true histiocytic origin are more resistant to radiation than tumours of lymphocytic origin.
Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome <i>c</i> release in response to several proapoptotic stimuli (2002)

Mitochondrial outer membrane permeabilization by proapoptotic Bcl-2 family proteins, such as Bax, plays a crucial role in apoptosis induction. However, whether this only causes the intracytosolic release of inducers of caspase-dependent death, such as cytochrome c, or also of caspase-independent death, such as apoptosis-inducing factor (AIF) remains unknown. Here, we show that on isolated mitochondria, Bax causes the release of cytochrome c, but not of AIF, and the association of AIF with the mitochondrial inner membrane provides a simple explanation for its lack of release upon Bax-mediated outer membrane permeabilization. In cells overexpressing Bax or treated either with the Bax- or Bak-dependent proapoptotic drugs staurosporine or actinomycin D, or with hydrogen peroxide, caspase inhibitors did not affect the intracytosolic translocation of cytochrome c, but prevented that of AIF. These results provide a paradigm for mitochondria-dependent death pathways in which AIF cannot substitute for caspase executioners because its intracytosolic release occurs downstream of that of cytochrome c.
Isolation and Characterization of Squamous Cell Carcinoma-Derived Stem-like Cells: Role in Tumor Formation (2013)

In human epidermis, keratinocyte stem cells (KSC) are characterized by high levels of β1-integrin, resulting in the rapid adhesion to type IV collagen. Since epithelial tumors originate from KSC, we evaluated the features of rapidly adhering (RAD) keratinocytes derived from primary human squamous cell carcinoma of the skin (cSCC). RAD cells expressed higher levels of survivin, a KSC marker, as compared to non-rapidly adhering (NRAD) cells. Moreover, RAD cells proliferated to a greater extent and were more efficient in forming colonies than NRAD cells. RAD cells also migrated significantly better than NRAD cells. When seeded in a silicone chamber and grafted onto the back skin of NOD SCID mice, RAD cells formed tumors 2-4 fold bigger than those derived from NRAD cells. In tumors derived from RAD cells, the mitotic index was significantly higher than in those derived from NRAD cells, while Ki-67 and survivin expression were more pronounced in RAD tumors. This study suggests that SCC RAD stem cells play a critical role in the formation and development of epithelial tumors.
Nitric oxide deficiency and endothelial–mesenchymal transition of pulmonary endothelium in the progression of 4T1 metastatic breast cancer in mice (2018)

Decreased eNOS activity and phosphorylation resulting in a low NO production state featuring pulmonary endothelial dysfunction was an early event in breast cancer pulmonary metastasis, preceding the onset of its phenotypic switch toward a mesenchymal phenotype (EndMT) evidenced by a decrease in VE-CAD and CD31 expression. The latter coincided with development of the first metastatic nodules in the lungs. These findings suggest that early endothelial dysfunction featured by NO deficiency rather than EndMT, might represent a primary regulatory target to prevent early pulmonary metastasis.
Border trap characterisation by measurements of current-voltage characteristics of MOS capacitors (2002)

Slow current transients in metal-oxide-semiconductor (MOS) capacitors have been observed and related to border traps (traps that are too slow to be classified as interface traps, and too fast to be classified as oxide traps). This paper describes border-trap related current transients induced by voltage stepping as a possible technique for both energy-level and time-response characterisation of the border traps. The voltage stepping measurements are compared to the standard linear voltage ramping technique.
Control of spectral distribution of Raman sidebands in impulsively stimulated rotational Raman scattering (2002)

We investigate the dependence of the intensity distribution of the impulsively stimulated rotational Raman sidebands from hydrogen gas on the polarization of the prepump and pump pulses. The results show that the energy flow direction of the pump pulse can be confined to either the Stokes side or the anti-Stokes side by changing the polarization of the 60 fs pump pulse. It is found that the use of a linearly polarized pump pulse is the most effective way to generate the largest number of Raman components as possible.