gebhart/patrepeval huggingface dataset:
Similar Dose Responsiveness of Hepatic Glycogenolysis and Gluconeogenesis to Glucagon In Vivo (1987)

This study was undertaken to determine whether the dose-dependent effect of glucagon on gluconeogenesis parallels its effect on hepatic glycogenolysis in conscious overnight-fasted dogs. Endogenous insulin and glucagon secretion were inhibited by somatostatin (0.8 micrograms X kg-1 X min-1), and intraportal replacement infusions of insulin (213 +/- 28 microU X kg-1 X min-1) and glucagon (0.65 ng X kg-1 X min-1) were given to maintain basal hormone concentrations for 2 h (12 +/- 2 microU/ml and 108 +/- 23 pg/ml, respectively). The glucagon infusion was then increased 2-, 4-, 8-, or 12-fold for 3 h, whereas the rate of insulin infusion was left unchanged. Glucose production (GP) was determined with 3-[3H]glucose, and gluconeogenesis (GNG) was assessed with tracer (U-[14C]alanine conversion to [14C]glucose) and arteriovenous difference (hepatic fractional extraction of alanine, FEA) techniques. Increases in plasma glucagon of 53 +/- 8, 199 +/- 48, 402 +/- 28, and 697 +/- 149 pg/ml resulted in initial (15-30 min) increases in GP of 1.1 +/- 0.4 (N = 4), 4.9 +/- 0.5 (N = 4), 6.5 +/- 0.6 (N = 6), and 7.7 +/- 1.4 (N = 4) mg X kg-1 X min-1, respectively; increases in GNG (approximately 3 h) of 48 +/- 19, 151 +/- 50, 161 +/- 25, and 157 +/- 7%, respectively; and increases in FEA (3 h) of 0.14 +/- 0.07, 0.37 +/- 0.05, 0.42 +/- 0.04, and 0.40 +/- 0.17, respectively. In conclusion, GNG and glycogenolysis were similarly sensitive to stimulation by glucagon in vivo, and the dose-response curves were markedly parallel.
Characterizing the caching and synchronization performance of a multiprocessor operating system (1992)

Good cache memory performance is essential to achieving high CPU utilization in shared-memory multiprocessors.
Real-time high-resolvance image correlation by Bragg diffraction in saturable absorbers (1980)

Real-time image correlation is achieved by coupling coherent Fourier spectra inside saturable absorbers. Previously described optical correlators using nonlinear susceptibilities are strongly limited by the angular selectivity of Bragg diffraction in thick interaction cells. We overcame these difficulties by a special 3-D arrangement of the interfering beams. High-quality quasi-real-time holographic images, enabling cross-correlationof photographic transparencies free of detection noise, are demonstrated.
Formula for self‐resonant frequency of Archimedean spiral coils (2014)

A simple empirical formula is proposed to calculate the self‐resonant frequency of Archimedean spiral coils made of circular wire. A spiral coil can be considered as a deformed straight wire with some specific structural parameters. Each structural parameter is assumed to affect the self‐resonant frequency. Two spiral coils, one that resonates near 13.56 MHz and one that resonates near 6.78 MHz, were fabricated to test the proposed formula. The average per cent error between the measured result and the calculated result was 2.66%. The proposed formula will be helpful in the design of Archimedean spiral coils for wireless power transfer.
<i>GIGANTEA</i>AND<i>SPINDLY</i>GENES LINKED TO THE CLOCK PATHWAY THAT CONTROLS CIRCADIAN CHARACTERISTICS OF TRANSPIRATION IN<i>ARABIDOPSIS</i> (2002)

Several "clock" genes that regulate the circadian system in Arabidopsis thaliana have been identified. The GIGANTEA (GI) gene has been shown to participate in the circadian system that is linked to overt rhythms in gene expression, leaf movements, hypocotyl elongation, and photoperiodic control of flowering in Arabidopsis. During continuous light (LL), circadian expression patterns in gi-2 mutants show reduced amplitudes and altered period lengths when compared with controls. Rhythms in stomatal function, such as transpiration, have been shown to be endogenous and persist in constant lighting conditions. In order to test for a physiologic variable that might be affected by the circadian clock via the GI gene, we compared circadian characteristics of transpiration between three Arabidopsis mutants (gi-2, spy-4, spy-4/gi-2) and wild-type (WT) controls in synchronized (LD for 2.5d) and free-running (LL for 3d) conditions. Each genotype showed a significant circadian rhythm in LD at p < 0.001, with acrophases located near the middle of the daily 14h L-span, with average amplitudes for WT: 18.9%, gi-2: 16.1%, spy-4: 7.7%, and spy-4/gi-2: 5.3%. On the first day in LL, the circadian amplitude was dramatically reduced to 3.1% for gi-2 compared with WT (11.9%), while amplitudes for spy-4 (6.9%) and spy-4/gi-2 (5.7%) were not significantly changed from LD. The amplitude for gi-2 remained low during days 2 (4.2%) and 3 (2.1%) in LL, while it slowly dampened for the WT (8.6 and 6.6%). The amplitudes for spy-4 (6.6%) and spy-4/gi-2 (5.6%) on day 2 in LL were indistinguishable from the LD span, but finally dampened on day 3 in LL (1.9 and 2.3%, respectively). These data suggest that transpiration is a physiologic variable controlled by a circadian system that involves both the GI and SPY proteins.
Ubiquitous inactivation of TRPM4 leads to elevated blood pressure in mice (2009)

Recently we showed that transient receptor potential TRPM4 proteins act as Ca 2+ ‐activated nonselective cation channels in mast cells that critically limit the driving force for Ca 2+ influx, release of inflammatory mediators and anaphylactic responses. In addition to mast cells we detected TRPM4 proteins in heart, aortic endothelial cells, kidney and adrenal gland from mice. Earley et al suggested that TRPM4 is expressed in vascular smooth muscle cells and it is supposed to act as a mechanosensor regulating vascular myogenic tone. Telemetric blood pressure measurements reveal that mean arterial blood pressure (MAP) is elevated in TRPM4‐/‐ mice by 11mmHg under basal conditions. Blood pressure elevation is observed during the complete circadian period and most notable under resting conditions. Plasma aldosterone levels, renin mRNA expression in the kidney and renin plasma concentrations are not different in TRPM4‐/‐ mice and there are no differences in MAP in response to application of phenylephrine (PE), norepinephrine and L‐NAME. PE induced contraction and acetylcholine induced relaxation of aortic rings is not altered. Currently we analyse the contractility of resistance vessels with respect to smooth muscle‐dependent contraction and endothelium‐dependent relaxation. Inhibition of ganglionic transmission with hexamethonium abolishes the difference in MAP between both genotypes similarly like application of prazosin. Analysis of plasma catecholamine level revealed a significant elevation of epinephrine in TRPM4‐/‐ mice. These results suggest that an increased neurogenic tone contributes to the development of the hypertension.
Reproductive Effects of the Mammalian Pineal (1970)

The reproductive systems of mammals are anatomically and physiologically altered by the pineal gland. Characteristically, pineal removal accelerates gonadal growth in immature animals and causes a transient modest enlargement of the reproductive organs if the operations are done after adulthood is attained. Light deprivation renders the pineal strongly antigonadotropic. In addition, there are several conditions, e.g., androgen-sterilization and anosmia, which potentiate, probably indirectly, the gonad-inhibiting capability of the rat's pineal. The chronic administration of pineal extracts or pineal substances has effects opposite to pinealectomy, i.e., they restrict gonadal development or growth. The pineal is possibly important in adjusting the level of reproductive activity to seasonal changes in environmental conditions.
Editorial (2000)

Research Article| January 01 2000 Editorial Joseph Melnick Joseph Melnick Search for other works by this author on: This Site Google Gestalt Review (2000) 4 (4): 259–261. https://doi.org/10.5325/gestaltreview.4.4.0259 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Joseph Melnick; Editorial. Gestalt Review 1 January 2000; 4 (4): 259–261. doi: https://doi.org/10.5325/gestaltreview.4.4.0259 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectivePenn State University PressGestalt Review Search Advanced Search The text of this article is only available as a PDF. Copyright © 2000 The Pennsylvania State University2000The Pennsylvania State University Article PDF first page preview Close Modal You do not currently have access to this content.
HTS fault current limiter concept (2004)

Fault current limiter (FCL) concepts based on non-inductive high temperature superconducting (HTS) coils were studied. The coils employed second generation (2G) HTS wire based on YBCO coated conductor currently under development at American superconductor corporation (AMSC) and other places. Two FCL concepts were studied: a) series and b) shunt. The series limiter employs a coil in series with the load and limits current by its increased resistance during the current limiting phase. This design is best for a single fault current limiting action, with resetting after the several minutes required cooling it down to its prefault temperature. The shunt limiter employs an inductor in parallel with the HTS coils. Once the HTS coil transitions to its normal state, fault current is limited by the impedance of the external inductor. An advantage of the shunt limiter is that with proper design, it could withstand multiple closely timed current limiting events. Since the 2G wire is becoming available in long lengths, now is the right time to initiate a commercial FCL product development program.
Designing DPA Resistant Circuits Using BDD Architecture and Bottom Pre-charge Logic (2013)

Differential power analysis (DPA) attacks are the most powerful side channel attacks against cryptographic systems. In this work, a reduced ordered binary decision diagram (ROBDD) based dual rail circuit for a basic DPA resistant cell has been designed. The specialty of this cell is that the overall input current of the cell is invariant to the input combinations of data bits applied to the cell. For the first time, bottom pre-charge logic is used in the design of such a cell. The ROBDD based design minimizes both area and early propagation effect. A number of logic functions including AND, OR, XOR, NOT, NAND, NOR and also an adder, all based on the basic cell, have then been designed in a hierarchical manner. Experimental results demonstrate DPA resistance of the circuits (for example an adder) developed using this cell, outperforming other competing design with respect to peak power variance.
A comparison of the combined load behaviour of spudcan and caisson foundations on soft normally consolidated clay (2004)

Experimental data from loading tests of model circular footings on soft normally consolidated clay are presented. The experiments were carried out on a drum centrifuge at a radial acceleration level equivalent to 100 times Earth's gravity, ensuring conditions of stress similitude between the model and the prototype scale. The aim of the experiments was to compare the undrained response of different offshore foundations to the same loading conditions. Two different types of foundation were targeted for investigation: spudcans and suction caissons. The spudcan, typically an inverted shallow cone, is the traditional footing for mobile drilling units (also known as jack-up rigs). An alternative foundation concept that is being increasingly considered is that of foundations skirted about the perimeter and installed by suction. A loading arm that incorporated an internal hinge was used so that combinations of load appropriate to the foundations of jack-up units could be applied to the models. Although it was anticipated that, by using skirted foundations there would be increased moment capacity, this was not found to be the case (for the caisson skirt length and soil strength profile investigated). However, there was a stiffer response and additional horizontal capacity at the foundation level. Significantly the use of skirted foundations allowed for a greater combined loading capacity under tensile vertical loads. The results have been interpreted within the framework of strain-hardening plasticity theory, and comparisons with existing yield surfaces are detailed.
Analysis and Modeling of a Voltage Doubler Rectifier Fed by a Piezoelectric Transformer (2004)

Piezoelectric transformers (PZT) can be used advantageously in high output voltage dc-dc converters. In such applications the output section includes a voltage doubling rectification scheme to help increase the output voltage. This topology was modeled and analyzed by considering the expected voltage and current waveforms under the first harmonics approximation. The results were then used to build a linear ac equivalent circuit that emulates the ac-dc stage. The proposed model was verified against simulation and experimental results.
A parallelized elliptic solver for reacting flows (1987)

A modified Newton algorithm for the solution of nonlinear elliptic boundary value problems via finite discretization methods is presented. A serial implementation of this algorithm which has recently been applied successfully to the computation of an axisymmetric over-ventilated subsonic laminar methane-air jet diffusion flame is described. Parallel implementation issues and a complexity theory are presented. Included as well are actual performance data for model systems obtained on the Intel Hypercube and a discussion of its implications for modeling realistic systems.
Serum lipid profile on admission for ischemic stroke (2007)

Many patients hospitalized with ischemic stroke/TIA, including those with known dyslipidemia and those taking lipid lowering agents, have measured low-density lipoprotein (LDL) that is higher than recommended by national guidelines. Patients at the greatest risk of cardiovascular events are the least likely to be at guideline-recommended LDL levels.
<i>Serrate</i>-mediated activation of <i>Notch</i> is specifically blocked by the product of the gene <i>fringe</i> in the dorsal compartment of the <i>Drosophila</i> wing imaginal disc (1997)

In the developing imaginal wing disc of Drosophila, cells at the dorsoventral boundary require localized Notch activity for specification of the wing margin. The Notch ligands Serrate and Delta are required on opposite sides of the presumptive wing margin and, even though activated forms of Notch generate responses on both sides of the dorsoventral boundary, each ligand generates a compartment-specific response. In this report we demonstrate that Serrate, which is expressed in the dorsal compartment, does not signal in the dorsal regions due to the action of the fringe gene product. Using ectopic expression, we show that regulation of Serrate by fringe occurs at the level of protein and not Serrate transcription. Furthermore, replacement of the N-terminal region of Serrate with the corresponding region of Delta abolishes the ability of fringe to regulate Serrate without altering Serrate-specific signaling.
Chemistry of Cephalosporin Antibiotics. VII. Synthesis of Cephaloglycin<sup>1</sup> and Some Homologs (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Cephalosporin Antibiotics. VII. Synthesis of Cephaloglycin1 and Some HomologsJohn L. Spencer, Edwin H. Flynn, Roger W. Roeske, Fai Y. Siu, and Robert R. ChauvetteCite this: J. Med. Chem. 1966, 9, 5, 746–750Publication Date (Print):September 1, 1966Publication History Published online1 May 2002Published inissue 1 September 1966https://pubs.acs.org/doi/10.1021/jm00323a024https://doi.org/10.1021/jm00323a024research-articleACS PublicationsRequest reuse permissionsArticle Views308Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prediction of Atrial Fibrillation in Patients with an Implantable Cardioverter-Defibrillator and Heart Failure (2010)

PA-TDI duration may be useful to risk-stratify for AF occurrence in heart failure patients with and without a history of AF.
Ultimate performances of oscillators in time domain (2002)

Assuming a noise free resonator the ultimate performances of an oscillator in time domain can be calculated. It shall be demonstrated that the ultimate time flicker level of an oscillator is only limited by two factors: the loaded Q of the resonator and the flicker noise level at 1 Hz of the amplifier phase noise. A chart can be drawn relating the three quantities /spl sigma//sub y/(/spl tau/), Q/sub loaded/ and /spl Lscr//sub ampli/(1 Hz). It is possible to see immediately that to obtain for example in time domain a flicker level of 5/spl times/10/sup -14/ using a resonator which exhibits a loaded Q coefficient of 6.5/spl times/10/sup 5/ we must use an amplifier with a flicker phase noise as low as /spl Lscr//sub amp/ (1 Hz)=-148 dBc/Hz. This performance level is hard to find in current amplifiers. Thus, it is of utmost importance to measure precisely the contributions of the amplifier to the noise in the oscillator loop. We introduce new system based on the injection principle giving an improvement of thirty dB versus the homodyne method and permitting measurements at -165 dB at 1 Hz for flicker noise and -190 dB for thermal noise. The advantages and ultimate performances of this new measurement system are described.
Low absorption InP/InGaAs-MQW phase shifters for optical switching (1995)

InP/InGaAs-MQW phase shifters with low absorption loss and low electroabsorption loss have been realized. Phase shift efficiency for TE-polarized light at lambda =1.55 mu m was 6.8 degrees V/sup -1/ mm/sup -1/ with negligible absorption loss and at lambda =1.51 mu m the efficiency was 8.9 degrees V/sup -1/ mm/sup -1/ with 5 dB/cm absorption loss
Enhancement of Charge-Transport Characteristics in Polymeric Films Using Polymer Brushes (2006)

We show that charge-transporting polymer chains in the brush conformation can be synthesized from a variety of substrates of interest, displaying a high degree of stretching and showing up to a 3 orders of magnitude increase in current density normal to the substrate as compared with a spin-coated film. These nanostructured polymeric films may prove to be suitable for electronic devices based on molecular semiconductors as current fabrication techniques often provide little control over film structure.
Frictional properties of interfaces including multiple microscopic contacts (2019)

Frictional properties of interfaces with dynamic chemical bonds have been the subject of intensive experimental investigation and modelling, as it provides important insights into the molecular origin of the empirical rate and state laws, which have been highly successful in describing friction from nano to geophysical scales. Using previously developed theoretical approaches requires time-consuming simulations that are impractical for many realistic tribological systems. To solve this problem and set a framework for understanding microscopic mechanisms of friction at interfaces including multiple microscopic contacts, we developed an analytical approach for description of friction mediated by dynamical formation and rupture of microscopic interfacial contacts, which allows to calculate frictional properties on the time and length scales that are relevant to tribological experimental conditions. The model accounts for the presence of various types of contacts at the frictional interface and predicts novel dependencies of friction on sliding velocity, temperature and normal load, which are amenable to experimental observations. Our model predicts the velocity-temperature scaling, which relies on the interplay between the effects of shear and temperature on the rupture of interfacial contacts. The proposed scaling can be used to extrapolate the simulation results to a range of very low sliding velocities used in nanoscale friction experiments, which is still unreachable by simulations. Considering friction force microscopy experiments (FFM), we reveal a mechanism of nonlinear dependence of friction on normal load observed in recent FFM experiments. Our work provides a promising avenue for the interpretation of the experimental data on friction at interfaces including microscopic contacts and open new pathways for the rational control of the frictional response.
Trimetazidine As Cardioplegia Addictive Without Pre-treatment Does Not Improve Myocardial Protection: Study In A Swine Working Heart Model [trimetazidina Como Aditivo Em Solução Cardioplégica Sem Pré-tratamento Não Traz Proteção Adicional Ao Miocárdio Isquêmico: Estudo Em Modelo Suíno De Coração Isolado] (2008)

Made available in DSpace on 2015-06-30T19:27:50Z (GMT). No. of bitstreams: 1 2-s2.0-53049106592.pdf: 201486 bytes, checksum: fbfe38cce01c458809402c511c8688a2 (MD5) Previous issue date: 2008
Fabrication of cermet bearings for the control system of a high temperature lithium cooled nuclear reactor (1973)

The techniques used to fabricate cermet bearings for the fueled control drums of a liquid metal cooled reference-design reactor concept are presented. The bearings were designed for operation in lithium for as long as 5 years at temperatures to 1205 C. Two sets of bearings were fabricated from a hafnium carbide - 8-wt. % molybdenum - 2-wt. % niobium carbide cermet, and two sets were fabricated from a hafnium nitride - 10-wt. % tungsten cermet. Procedures were developed for synthesizing the material in high purity inert-atmosphere glove boxes to minimize oxygen content in order to enhance corrosion resistance. Techniques were developed for pressing cylindrical billets to conserve materials and to reduce machining requirements. Finishing was accomplished by a combination of diamond grinding, electrodischarge machining, and diamond lapping. Samples were characterized in respect to composition, impurity level, lattice parameter, microstructure and density.
Low- and very low-radiofrequency model ionosphere reflection coefficients (1960)

reflection coefficients. N= 1.2(10 ), v = 10 , d>. = 80. 397, H = 0. 5, I = 84. 270, f = 10 kc, l m