gebhart/patrepeval huggingface dataset:
[Regulation of hematopoiesis]. (1994)

Hematopoiesis is regulated by a tiny population of cells, the stem cells and committed progenitors. These cells are under the influence of hematopoietic growth factors most of which are produced immediately in their environments. Their fates are strongly influenced by those growth factors. The growth factors interact with specific receptors that are present on progenitor surfaces and may in fact induce changes in the levels of those receptors. The receptors form dimers or heterodimers to pass proliferative and differentiation signals into the cell. We do not yet know exactly how that signalling is accomplished, but will probably known much more about it in the next year or so.
Hemorheological and antioxidant effects of Ascovertin in patients with sclerosis of cerebral arteries. (2004)

The clinical trials on 31 patients with arteriosclerosis and I-II stage discirculatory encephalopathy to assess an ability of Ascovertin to limit hemorheology abnormalities were carried out. In patients with discirculatory encephalopathy was a distinct increase in blood viscosity which was induced by disturbances of cell rheological factors: increase in aggregation of erythrocytes and decrease in their deformability were observed in comparison with indices in the group of healthy volunteers. No difference in plasma viscosity and fibrinogen was found. The treatment with Ascovertin in patients with discirculatory encephalopathy improved their attention, memory, mental performance, normalized sleep, releaved headache, decreased fatiquebility, led to the decrease in blood viscosity values, the reduction of pathological erythrocyte hyper aggregation and the improvement of erythrocyte deformability. We partly connect this clinical effect and hemorheology activity of Ascovertin with its antioxidant property--there was found impressive lipid peroxidation suppression. No significant changes in hemorheological and lipid peroxidation indices were observed in patients without Ascovertin.
Multiple mirror telescope as a phased array telescope (1985)

By adjusting the optical path lengths of its individual beams, it is possible to make the multiple mirror telescope (MMT) into a phased array with a 6.86-m base line. A coherent phased focus can be achieved with tilted focal planes if the tilt angle is chosen so that the internal phase differences exactly compensate the external phase differences. This amounts to a slight change in configuration so that the beams are brought together at f/8.39 rather than the originally designed f/9. We summarize experiments which have used the MMT subapertures as a phased array and as a coherent phased telescope and present a simple analysis of the titled focal plane geometry for coherent observation. The phased operation of the MMT is important not only for obtaining high angular resolution but also for obtaining the higher detection sensitivity which results from the better discrimination against the sky emission background for IR diffraction-limited images. Full-aperture (six-beam) diffraction-limited results for the unresolved source Gama Orionis, the well-known close binary Capella, and the resolved red supergiant Betelgeuse (including a diffraction-limited differential speckle image of the latter) are presented as preliminary demonstration of the potential capabilities of this configuration.
Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome (2007)

Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of the enzymatic deficiency. The prevalence is estimated at 1/380,000 live births in Canada, and 1/235,000 live births in Spain. Uric acid overproduction is present inall HPRT-deficient patients and is associated with lithiasis and gout. Neurological manifestations include severe action dystonia, choreoathetosis, ballismus, cognitive and attention deficit, and self-injurious behaviour. The most severe forms are known as Lesch-Nyhan syndrome (patients are normal at birth and diagnosis can be accomplished when psychomotor delay becomes apparent). Partial HPRT-deficient patients present these symptoms with a different intensity, and in the least severe forms symptoms may be unapparent. Megaloblastic anaemia is also associated with the disease. Inheritance of HPRT deficiency is X-linked recessive, thus males are generally affected and heterozygous female are carriers (usually asymptomatic). Human HPRT is encoded by a single structural gene on the long arm of the X chromosome at Xq26. To date, more than 300 disease-associated mutations in the HPRT1 gene have been identified. The diagnosis is based on clinical and biochemical findings (hyperuricemia and hyperuricosuria associated with psychomotor delay), and enzymatic (HPRT activity determination in haemolysate, intact erythrocytes or fibroblasts) and molecular tests. Molecular diagnosis allows faster and more accurate carrier and prenatal diagnosis. Prenatal diagnosis can be performed with amniotic cells obtained by amniocentesis at about 15-18 weeks' gestation, or chorionic villus cells obtained at about 10-12 weeks' gestation. Uric acid overproduction can be managed by allopurinol treatment. Doses must be carefully adjusted to avoid xanthine lithiasis. The lack of precise understanding of the neurological dysfunction has precluded development of useful therapies. Spasticity, when present, and dystonia can be managed with benzodiazepines and gamma-aminobutyric acid inhibitors such as baclofen. Physical rehabilitation, including management of dysarthria and dysphagia, special devices to enable hand control, appropriate walking aids, and a programme of posture management to prevent deformities are recommended. Self-injurious behaviour must be managed by a combination of physical restraints, behavioural and pharmaceutical treatments.
Sodium Palconate Production (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSodium Palconate ProductionFrank A. Kottwitz and Loren V. FormanCite this: Ind. Eng. Chem. 1948, 40, 12, 2443–2450Publication Date (Print):December 1, 1948Publication History Published online1 May 2002Published inissue 1 December 1948https://pubs.acs.org/doi/10.1021/ie50468a035https://doi.org/10.1021/ie50468a035research-articleACS PublicationsRequest reuse permissionsArticle Views12Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Telaprevir: A Novel NS3/4 Protease Inhibitor for the Treatment of Hepatitis C (2011)

Hepatitis C virus (HCV) infection affects millions of people worldwide; however, standard therapy with peginterferon and ribavirin has resulted in suboptimal responses. Thus, new anti-HCV drugs with novel mechanisms of action are being studied. In particular, new drugs are being developed that target the NS3/4A protease complex. We evaluated the literature on telaprevir, a new, oral, covalent, reversible NS3/4A HCV protease inhibitor. A MEDLINE search (January 1996-July 2011) was performed to identify relevant clinical trials, and abstracts from hepatology and human immunodeficiency virus (HIV) conferences were reviewed. In large clinical trials, the addition of telaprevir to peginterferon and ribavirin resulted in high sustained virologic response rates in both treatment-naïve and treatment-experienced patients infected with HCV genotype 1. Clinical data with telaprevir in the HIV-HCV coinfected population are emerging, as well as data on potential drug-drug interactions with this agent. Preliminary data describe the resistance profile of telaprevir; however, more information is needed in this evolving area. Telaprevir's most common adverse events included rash, pruritis, and anemia. Based on available data, this new anti-HCV drug will likely be widely used and may revolutionize the treatment of HCV-infected individuals.
The Dominance of the Herbicide Resistance Cost in Several <i>Arabidopsis thaliana</i> Mutant Lines (2004)

Resistance evolution depends upon the balance between advantage and disadvantage (cost) conferred in treated and untreated areas. By analyzing morphological characters and simple fitness components, the cost associated with each of eight herbicide resistance alleles (acetolactate synthase, cellulose synthase, and auxin-induced target genes) was studied in the model plant Arabidopsis thaliana. The use of allele-specific PCR to discriminate between heterozygous and homozygous plants was used to provide insights into the dominance of the resistance cost, a parameter rarely described. Morphological characters appear more sensitive than fitness (seed production) because 6 vs. 4 differences between resistant and sensitive homozygous plants were detected, respectively. Dominance levels for the fitness cost ranged from recessivity (csr1-1, ixr1-2, and axr1-3) to dominance (axr2-1) to underdominance (aux1-7). Furthermore, the dominance level of the herbicide resistance trait did not predict the dominance level of the cost of resistance. The relationship of our results to theoretical predictions of dominance and the consequences of fitness cost and its dominance in resistance management are discussed.
Biochemical and Cytotoxic Properties of Conjugates of Transferrin with Equinatoxin II, a Cytolysin from a Sea Anemone (1995)

Transferrin, a serum glycoprotein, is a major regulator of cellular growth via its cellular receptor. Because transferrin receptors are absent from the plasma membranes of most normal adult resting cells, but are present on transformed, activated, and malignant cells, it can be used to address a toxin toward these cells. The cytolysin equinatoxin II, isolated from the sea anemone Actinia equina L., was coupled to human apo or diferric transferrin by using a heterobifunctional cross-linking reagent, N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP). The conjugates were separated by column chromatography, and their composition was demonstrated by electrophoresis, antibody staining, and determination of the hemolytic activity in the absence or presence of a reducing agent. The average molar ratio of equinatoxin II to transferrin for the studied conjugates was found to be approximately 3.4. The activity of the conjugates against human erythrocytes and human tumor cells (Raji and Jurkat) was assessed. The conjugate is very active on tumor cells in vitro; however, the hybrid molecule maintains an unspecific hemolytic activity. This unspecific toxicity is due to the fact that transferrin-bound toxin partially retains its original ability to bind to the cell membrane directly. It could be strongly reduced (and even eliminated) by pretreating the conjugates with sphingomyelin, the natural ligand of sea anemone cytolysins. These conjugates were stable versus temperature (up to at least 40 degrees C), versus time (up to several weeks at 4 degrees C and at least 1 year at -80 degrees C), and versus repeated freeze-thaw cycles with liquid nitrogen (but not with -80 degrees C).
A Detailed Survey for Detection and Mitigation Techniques against ARP Spoofing (2020)

In computer networking, ARP (ADDRESS RESOLUTION PROTOCOL) is used widely to translate IP address to its corresponding MAC address. In the case of no malicious user, it works quite decently. But as soon as an attacker comes into play, it links its MAC address to the given IP address, thus, making it susceptible to a spoofing attack called ARP Spoofing Attacks. This paper first gives an overview of ARP and its working. Then discusses ARP Spoofing and its various attacks. Finally, provides the comparison of different detection and mitigation techniques along with their pros and cons to control ARP attacks. In this paper, 11 journals have been included.
Cocrystals of 3,5-Dimethyl-1<i>H</i>-pyrazole and Salicylic Acid:  Controlled Formation of Trimers via O−H···N Hydrogen Bonds (2007)

Solid-state reactions of 3,5-dimethyl-1H-pyrazole (dmpz) and salicylic acid (sa) in different stoichiometries afford two different trimers whose structures have been determined by X-ray diffraction and analyzed by 13C and 15N solid-state nuclear magnetic resonance spectroscopy. GIAO absolute shieldings at the B3LYP/6-311++G** level have been calculated and compared with the experimental chemical shifts. Hydrogen-bond interactions between dmpz and sa provide sufficient driving force to direct molecular recognition and crystal packing.
A 250-MHz monolithic voltage-controlled oscillator with low temperature coefficient (1990)

A monolithic voltage-controlled oscillator (VCO) with dual-loop feedback, designed and fabricated in a 2- mu m oxide-isolated bipolar technology, is discussed. The VCO, consuming 220 mW from a single 5-V supply and occupying 2200 mil/sup 2/, achieves a -65 p.p.m./ degrees C temperature coefficient of frequency. It has a 5:1 frequency control range, and the maximum oscillation frequency is 250 MHz with better than a 2% voltage-to-frequency linearity. The modulation bandwidth of the VCO is greater than 12 MHz, and the power supply rejection ratio is 0.4%/V.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prediction of Aneurysm Stability Using a Machine Learning Model Based on PyRadiomics-Derived Morphological Features (2019)

Background and Purpose- Discrimination of the stability of intracranial aneurysms is critical for determining the treatment strategy, especially in small aneurysms. This study aims to evaluate the feasibility of applying machine learning for predicting aneurysm stability with radiomics-derived morphological features. Methods- Morphological features of 719 aneurysms were extracted from PyRadiomics, of which 420 aneurysms with Maximum3DDiameter ranging from 4 mm to 8 mm were enrolled for analysis. The stability of these aneurysms and other clinical characteristics were reviewed from the medical records. Based on the morphologies with/without clinical features, machine learning models were constructed and compared to define the morphological determinants and screen the optimal model for predicting aneurysm stability. The effect of clinical characteristics on the morphology of unstable aneurysms was analyzed. Results- Twelve morphological features were automatically extracted from PyRadiomics implemented in Python for each aneurysm. Lasso regression defined Flatness as the most important morphological feature to predict aneurysm stability, followed by SphericalDisproportion, Maximum2DDiameterSlice, and SurfaceArea. SurfaceArea (odds ratio [OR], 0.697; 95% CI, 0.476-0.998), SphericalDisproportion (OR, 1.730; 95% CI, 1.143-2.658), Flatness (OR, 0.584; 95% CI, 0.374-0.894), Hyperlipemia (OR, 2.410; 95% CI, 1.029-5.721), Multiplicity (OR, 0.182; 95% CI, 0.082-0.380), Location at middle cerebral artery (OR, 0.359; 95% CI, 0.134-0.902), and internal carotid artery (OR, 0.087; 95% CI, 0.030-0.211) were enrolled into the final prediction model. In terms of performance, the area under curve of the model reached 0.853 (95% CI, 0.767-0.940). For unstable aneurysms, Compactness1 (P=0.035), Compactness2 (P=0.036), Sphericity (P=0.035), and Flatness (P=0.010) were low, whereas SphericalDisproportion (P=0.034) was higher in patients with hypertension. Conclusions- Morphological features extracted from PyRadiomics can be used for aneurysm stratification. Flatness is the most important morphological determinant to predict aneurysm stability. Our model can be used to predict aneurysm stability. Unstable aneurysm is more irregular in patients with hypertension.
Effects of fluorescent lights on signal fading characteristics for indoor radio channels (1992)

Measurements of in-building radio signals show that plasma, inside fluorescent lights, reflects sinals at twice the frequency of the power network. These reflections produce fading of receiver signals at 120 Hz with power variations ranging from a few tenths of a decibel to more than 20dB and phase variations from less than 20° to 100°
A review of 0.18-/spl mu/m full adder performances for tree structured arithmetic circuits (2005)

The general objective of our work is to investigate the area and power-delay performances of low-voltage full adder cells in different CMOS logic styles for the predominating tree structured arithmetic circuits. A new hybrid style full adder circuit is also presented. The sum and carry generation circuits of the proposed full adder are designed with hybrid logic styles. To operate at ultra-low supply voltage, the pass logic circuit that cogenerates the intermediate XOR and XNOR outputs has been improved to overcome the switching delay problem. As full adders are frequently employed in a tree structured configuration for high-performance arithmetic circuits, a cascaded simulation structure is introduced to evaluate the full adders in a realistic application environment. A systematic and elegant procedure to scale the transistor for minimal power-delay product is proposed. The circuits being studied are optimized for energy efficiency at 0.18-/spl mu/m CMOS process technology. With the proposed simulation environment, it is shown that some survival cells in stand alone operation at low voltage may fail when cascaded in a larger circuit, either due to the lack of drivability or unsatisfactory speed of operation. The proposed hybrid full adder exhibits not only the full swing logic and balanced outputs but also strong output drivability. The increase in the transistor count of its complementary CMOS output stage is compensated by its area efficient layout. Therefore, it remains one of the best contenders for designing large tree structured arithmetic circuits with reduced energy consumption while keeping the increase in area to a minimum.
Injury as Alienation in Sport (1989)

(1989). Injury as Alienation in Sport. Journal of the Philosophy of Sport: Vol. 16, No. 1, pp. 44-58.
Nitrogen heterocycle and polynuclear hydrocarbon fluorescence and adsorption effects in the presence of silica gel. Applications in high-pressure liquid and microcolumn chromatography (1975)

A flow-through cell packed with silica gel is used for the spectrofluorimetric examination of adsorbed states and as a detector in high-pressure liquid chromatography. The intensified fluorescence of adsorbed benzo homologues of quinoline and acridine is found to be caused by protonation of the electronically excited states by the gel. Sub-nanogram amounts of such compounds can therefore be analysed by high-pressure liquid chromatography.In the presence of silica gel the fluorescence of polynuclear hydrocarbons is enhanced proportionally to their radiative lifetimes. The effect is disfavoured by adsorbate formation, and can therefore be employed in both adsorption and reversed-phase liquid chromatography in order to improve selectivity and sensitivity towards readily quenched fluorescences.Microcolumns (90 × 1 mm) exhibit a ten-fold reduction in theoretical plate height compared with conventional high-pressure columns of the same adsorbent. Separations in such columns mounted on a microscope stage can be monitored by spectrofluorimetric microscopy of a silica gel particle located at the end of the column.The techniques described are applied to heterocycles in creosotes, polynuclear hydrocarbons in gasolines and sump oil, and wood splinters, soot particles and trace amounts of pitch.
Characterization of human GRK7 as a potential cone opsin kinase. (2001)

The presence of GRK7 in human, but not in mouse, cone outer segments suggests that GRK7 may function to provide the normal photopic vision reported by oguchi patients with a defective GRK1 gene. The absence of GRK7 expression in cone outer segments of mice is consistent with the notion that mouse cones rely solely on GRK1 to shutoff cone visual pigments.
A virtual mouse system for mobile device (2005)

This paper presents a novel virtual mouse system for mobile phones. The system is based on computer vision techniques. It first captures an image using the camera of the mobile phone, then extracts feature points of the scene and tracks them. By using this algorithm we can estimate the camera motion and give the translation vector to our virtual mouse interface. We use NOKIA 6630 camera phone as the developing platform which has a Mega Pixel camera on the back of it. The experiments show the promising results.
A novel chaos-based high-resolution imaging technique and its application to through-the-wall imaging (2005)

In this letter, we present a novel chaos-based imaging technique. The proposed technique has good range-Doppler resolution and excellent side lobe suppression characteristics that promise immense potential for high-resolution imaging applications. We derive the range and Doppler resolution functions of the proposed technique and compare it with that of conventional time modulation-based imaging. Additionally, the noise performance of the proposed scheme is derived to show the improvement compared to the conventional amplitude and time modulation schemes. The proposed imaging technique is applied to through-the-wall radar imaging. Numerical electromagnetic simulations are performed to illustrate the effectiveness of the proposed technique.
Detection of Human Papillomavirus DNA in Cervical Samples: Analysis of the New PGMY-PCR Compared To the Hybrid Capture II and MY-PCR Assays and a Two-Step Nested PCR Assay (2004)

The PGMY-PCR for human papillomavirus (HPV) was evaluated, in parallel with nested PCR (nPCR), in samples with noted Hybrid Capture II (HCII) and MY-PCR results. PGMY-PCR detected HPV DNA in 2.5% of HCII-negative-MY-PCR-negative samples and in 71.7% of HCII-positive-MY-PCR-negative samples; also, it detected the MY-PCR-negative-nPCR-negative types HPV-42, HPV-44, HPV-51, HPV-87, and HPV-89.
IPMN Symposium on Performance Budgeting and the Politics of Reform (2002)

Various systems to integrate performance measurement into budgeting are applied in nations around the world. Governments at all levels have embarked on a journey into performance measurement and management. Performance budgeting, and the application of performance analysis in budgeting, is a topic of a considerable discourse in the public management community. This symposium provides dialogue and comment on efforts to integrate performance evaluation into the executive budget process at the federal government level in the United States of America under the administration of President George W. Bush. The experience of other nations also is addressed.