gebhart/patrepeval huggingface dataset:
Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes (2015)

Granulocyte colony-stimulating factor (G-CSF) has been used to restore immune competence following chemoablative cancer therapy and to promote immunological tolerance in certain settings of autoimmunity. Therefore, we tested the potential of G-CSF to impact type 1 diabetes (T1D) progression in patients with recent-onset disease [n = 14; n = 7 (placebo)] and assessed safety, efficacy and mechanistic effects on the immune system. We hypothesized that pegylated G-CSF (6 mg administered subcutaneously every 2 weeks for 12 weeks) would promote regulatory T cell (Treg) mobilization to a degree capable of restoring immunological tolerance, thus preventing further decline in C-peptide production. Although treatment was well tolerated, G-CSF monotherapy did not affect C-peptide production, glycated haemoglobin (HbA1c) or insulin dose. Mechanistically, G-CSF treatment increased circulating neutrophils during the 12-week course of therapy (P < 0·01) but did not alter Treg frequencies. No effects were observed for CD4(+) : CD8(+) T cell ratio or the ratio of naive : memory (CD45RA(+)/CD45RO(+)) CD4(+) T cells. As expected, manageable bone pain was common in subjects receiving G-CSF, but notably, no severe adverse events such as splenomegaly occurred. This study supports the continued exploration of G-CSF and other mobilizing agents in subjects with T1D, but only when combined with immunodepleting agents where synergistic mechanisms of action have previously demonstrated efficacy towards the preservation of C-peptide.
The Immediate Effect of Whole Body Vibration on Core Muscles in Young Healthy Females: A Preliminary Study (2019)

Introduction: Previous studies showed that Whole Body Vibration (WBV) is an effective modality for strength and power. WBV has many usages in training and rehabilitation. Core muscles have the central role in the stability of the spine and our daily activity; so, strengthening core muscles is essential. This study aimed to investigate the immediate effect of WBV on strength, endurance, and performance of core muscles in young, healthy females. Materials and Methods: This study was a quasi-experimental interventional study. Twelve young, healthy females (18-28 years old) participated in this study; they received WBV in semi-squat position 5 times in 60 seconds separated by 30-second rest. The parameters of WBV included the frequency of 30Hz and an amplitude of 4mm. The tests used for the evaluation of core stability included Vertical Jump (VJ), pressure biofeedback, front abdominal power, trunk extensor endurance, and trunk flexor endurance tests. The tests were performed before, immediately after, and 30 minutes after the intervention. Results: According to the results, the trunk extensor endurance test, front abdominal power test, and pressure biofeedback had a significant effect (P<0.05). However, no change was observed in the trunk flexor endurance test and VJ test (P>0.05). Conclusion: This study indicated that WBV could be useful in core stability, specifically for trunk extensor endurance, lumbar strength, and front abdominal power. More studies are required to prove the effect of WBV on VJ and trunk flexor endurance.
Identification and Characterization of a Papillomavirus from Birds (Fringillidae) (1977)

From skin papillomas of the chaffinch (Fringilla coelebs), a virus has been purified and studied by physicochemical techniques and electron microscopy. The virions measure 52 nm in diameter and are composed of 72 morphological units arranged in a skew T = 7d surface lattice. A sedimentation coefficient of about 300S and a buoyant density of 1.34 g/ml in CsCl were determined for the particle. Its protein composition resembles that of human papillomavirus, and the circular double-stranded genome measures 2.6 micronm. This is the first demonstration of a member of the Papovaviridae family that affects a nonmammalian host.
An Optical System for an Automatic Eye Refractor (1978)

Various instruments to measure the refractive state of the eye have been built based on a servosystem concept. This paper describes the optical system of the Dioptron automatic objective refractor. This autorefractor measures the modulation of a grating image formed on the retina while being controlled by a digital computer. The optical subsystems include the image projecting system, the image detecting system, the patient fixation target, and the patient alignment system. Accuracy is obtained by controlling the patient's accommodation and eliminating "instrument" myopia. The overall system is designed to be compact while maintaining very good signal-to-noise ratio and minimum operator controls.
Control versus compute power within a LEDR-style self-timed multiplier with bypass path (2003)

The design of a self-timed multiplier using Level-Encoded Dual Rail IO is presented. A concern with LEDR compute blocks is the ratio of the power consumed by the control logic used for dual rail IO signal decoding/encoding and arrival detection versus the power needed for the actual computation. Boolean multipliers using a CSA architecture of sizes 8/spl times/8=16 and 16/spl times/16=32 are implemented via a 0.5u standard cell library. Post-layout transistor level simulations indicate a compute to control ratio of 1.2 for the 8/spl times/8 multiplier, and 2.5 for the 16/spl times/16 multiplier. These ratios are improved to 3.4 and 8.3 respectively via alternate versions of the multipliers that use bundled data signaling to reduce control power. The multiplier design includes a bypass path that allows the combinational delay of the multiplier to be skipped if the multiplier result is not required.
In-hospital outcomes and long-term mortality according to gender and management strategy in acute myocardial infarction. Insights from the FAST-MI 2005 registry (2013)

ACS-free survival estimate significant predictors of all-cause mortality (hazard ratios: APN, 5.02; p < 0.001; CRP, 3.43, p < 0.001). The rate of ACS recurrence was significantly associated with APN levels. However, the other biomarkers did not show relationships with ACS recurrence. Multivariate analyses adjusted for APN, age, body mass index, diabetes, hypertension, smoking, and dyslipidemia identified the median and highest tertile of APN levels as the only predictors of ACS recurrence (hazard ratios: median, 4.46, p = 0.024; highest, 6.63, p = 0.005). Conclusions: Among the established biomarkers related to patient prognosis, APN was the most useful predictor of all-cause mortality and ACS recurrence.
Acaricide Efficacy on Spider Mite and Spider Mite Predators on Almonds, 1986 (1988)

Abstract Trees were drip-irrigated, 6-yr-old ‘Nonpareil’ or ‘Carmel’ almond trees, and were located in a commercial orchard near Shatter, Calif. Treatments were assigned according to a randomized complete block design consisting of 8 single-tree replicates that were blocked by almond variety and location. Treatments were applied on 1 and 2 Jul as a dilute spray by high pressure handgun (ca 400 psi). Trees were sprayed until runoff, which resulted in an application rate of 650 gal/acre. Twenty leaves were sampled from the 4 cardinal point quadrants of each tree (5 leaves/quadrant) and examined under a dissecting microscope to obtain counts of spider mites and spider mite predators. Pretreatment spider mite predators consisted mainly of phytoseiid mites (50.3%), which included WPM, Metaseiulus mcgregori (Chant), and Euseius (Amblyseius) tularensis Congdon, and of sixspotted thrips (48.4%). Posttreatment samples consisted of 5.9% phytoseiid mites, 77.2% sixspotted thrips, 9.8% Chrysopa, 0.9% spider mite destroyer, Stethorus picipes, and 6.2% other predators (mainly cecidomyiid larvae, probably Feltiella sp.). Eggs were excluded from all spider mite and predator counts with the exception of Stethorus and Chrysopa eggs.
Modular Strapdown Guidance Unit with Embedded Microprocessors (1980)

The Low-Cost Inertial Guidance System (LCIGS) is a modular strapdown implementation of attitude (gyro) and velocity (accelerometer) axes which permits the interchangeable use of different manufacturer's instruments without affecting the system's electronic or mechanical interfaces or processing software. This design flexibility is made possible by the use of microprocessors for processing and control. The microprocessors are embedded in each module and five are used: one per accelerometer triad, one each per gyro module, and one in the service module. The processors effect on-line digital torquing control of the gyros, active instrument error model compensation, including modeling for temperature sensitivity effects, temperature control, self-testing, etc. Adaptation of processing and calibration algorithms to accommodate for instrument changes or sensed environmental variations is achieved through the use of an alterable read-only data base that may be updated by the LCIGS support equipment as required at calibrations or upon an instrument replacement. This data base is accessed by the microprocessors and used to compute coefficient corrections for the processing algorithms. The system architecture is presented and the microprocessor software partitioning and functions are described.
완화진동억압을 이용한 10GHz 고조모드잠금된 고리형 어븀첨가 광섬유 레이저의 출력 안정화 및 특성 측정 (2002)

마하젠더형 광세기 변조기를 이용하여 10 ㎓로 고조모드잠금된 분산보상 어븀첨가 광섬유 레이저의 출력 안정화 되먹임 제어를 하고 출력의 안정도를 측정하였다. 레이저의 출력 불안정성이 발생하였을 때 나타나는 완화진동 주파수 성분을 억압하도록 공진기 길이를 조정하여 16시간 이상 출력 안정화를 시켰다. 이때, 안정화가 진행되는 동안 rms 위상잡음과 rms 진폭잡음은 각각 260 fsec~524 fsec와 4~11.5%의 사이에 분포하였고, BER은 10-¹³으로 측정되었다.
Targeting sarcoma tumor-initiating cells through differentiation therapy (2017)

Human leukocyte antigen class I (HLA-I) down-regulation has been reported in many human cancers to be associated with poor clinical outcome. However, its connection to tumor-initiating cells (TICs) remains unknown. In this study, we report that HLA-I is down-regulated in a subpopulation of cells that have high tumor initiating capacity in different types of human sarcomas. Detailed characterization revealed their distinct molecular profiles regarding proliferation, apoptosis and stemness programs. Notably, these TICs can be induced to differentiate along distinct mesenchymal lineages, including the osteogenic pathway. The retinoic acid receptor signaling pathway is overexpressed in HLA-1 negative TICs. All-trans retinoic acid treatment successfully induced osteogenic differentiation of this subpopulation, in vitro and in vivo, resulting in significantly decreased tumor formation. Thus, our findings indicate down-regulated HLA-I is a shared feature of TICs in a variety of human sarcomas, and differentiation therapy strategies may specifically target undifferentiated TICs and inhibit tumor formation.
The Growth of CuInSe<sub>2</sub> Films Deposited by Sputtering and Its Application to Solar Cells (1993)

CuInSe 2 films have been deposited onto Mo-coated glass substrates by elemental three-source sputtering and hybrid sputtering. Near-stoichiometric films by three-source sputtering exhibited considerably small grain size and poor crystallinity which led to low cell performance. On the other hand, hybrid-deposited films exhibited much larger grain sizes ranging from 0.5 to 1 µm, although a large number of planar defects such as twins on {112} plane of chalcopyrite structure. Preliminary solar cells with ZnO/CdS/CuInSe 2 structure using hybrid-deposited material resulted in a conversion efficiency of 7.8%.
The Hydrolysis of Aryl Sulfites<sup>1,2</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Hydrolysis of Aryl Sulfites1,2C. A. Bunton and G. SchwerinCite this: J. Org. Chem. 1966, 31, 3, 842–848Publication Date (Print):March 1, 1966Publication History Published online1 May 2002Published inissue 1 March 1966https://pubs.acs.org/doi/10.1021/jo01341a047https://doi.org/10.1021/jo01341a047research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Glucocorticoid Inhibition of Granulocyte Macrophage–Colony-Stimulating Factor from T cells Is Independent of Control by Nuclear Factor-κB and Conserved Lymphokine Element 0 (2003)

Release of granulocyte macrophage-colony-stimulating factor (GM-CSF) from T cells is important in the differentiation, maturation, and survival of inflammatory cells. Here the induction of GM-CSF expression from T cells was dependent on transcription and translation and was prevented by dexamethasone. In primary human CD3(+) T cells, up to 3.3 kb of human GM-CSF promoter was strongly activated by PMA + PHA. Mutations in either the -85/-76 nuclear factor (NF)-kappaB site or the activator protein-1 region in the -54/-31 conserved lymphokine element 0 (CLE0) site substantially reduced promoter activity. Both GM-CSF promoter and NF-kappaB-dependent constructs were unresponsive to dexamethasone whereas the release of GM-CSF was potently repressed. Analysis of GM-CSF mRNA and protein expression at various time points and the effect of adding dexamethasone after the stimulus revealed the existence of potent mechanisms of inhibition acting at a translational level. The expression of tristetraproline and HuR, proteins that bind the AU-rich element in the GM-CSF 3'-untranslated region was unaffected by dexamethasone and overall AU-rich element binding activity was unaltered. Taken together our data support an important role for the NF-kappaB and CLE0 sites in the transcriptional control of GM-CSF expression in primary human T cells and suggest that post-transcriptional/translational mechanisms are key mediators of glucocorticoid-dependent repression.
Preparation of Au-Bi<sub>2</sub>O<sub>3</sub>Nanocomposite by Anodic Electrodeposition Combined with Galvanic Replacement (2014)

Nanocomposite films of Au-modified bismuth oxide (Au-Bi2O3) were synthesized via anodic electrodeposition of Bi combined with a galvanic replacement reaction. First, Bi2O3 was prepared by the anodic oxidation of pre-electrodeposited Bi films in 0.1 M NaOH electrolyte. The amount of metallic bismuth in Bi2O3 was tuned by controlling the oxidation time or deposition potential. Thus-prepared Bi-Bi2O3 composite was converted to Au-Bi2O3 by galvanically replacing metallic Bi with Au from an aqueous HAuCl4 solution. The photocatalytic activity of the Au-Bi2O3 nanocomposite for decomposition of methyl orange dye was superior to that of the bare Bi2O3 counterpart under UV as well as visible light illumination.
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR (1965)

Departments of Anesthesiology, Neurology and Obstetrics, Bronx Municipal Hospital Center, Albert Einstein College of Medicine, New York, New York
Synthese und Isolierung von Heptafulven und Sesquifulvalen (1975)

Abstract The synthesis and isolation of heptafulvene ( 1 ) and sesquifulvalene ( 2 ) is reported: Acetoxy‐tropylium‐fluoroborate ( 10 ) may be prepared by addition of tropone to acetyl‐fluoroborate at low temperatures. The tropylium salt reacts easily with methyllithium and sodium cyclopentadienide to give the acetoxy‐methyl‐cycloheptatrienes 11 and the acetoxy‐cyclopentadienyl‐cycloheptatrienes 12 respectively. Gas‐phase pyrolysis of 11 and 12 affords in remarkably good yields heptafulvene ( 1 ) and sesquifulvalene ( 2 ), which are isolated in cristalline form at low temperatures. Spectroscopic as well as chemical evidence of the title compounds is presented.
Fermi surfaces of surface states on Si(111)-Ag, Au (2002)

Metallic surface states on semiconducting substrates provide an opportunity to study low-dimensional electrons decoupled from the bulk. Angle resolved photoemission is used to determine the Fermi surface, group velocity, and effective mass for surface states on $\mathrm{Si}(111)\sqrt{3}\ifmmode\times\else\texttimes\fi{}\sqrt{3}\ensuremath{-}\mathrm{Ag},$ $\mathrm{Si}(111)\sqrt{3}\ifmmode\times\else\texttimes\fi{}\sqrt{3}\ensuremath{-}\mathrm{Au},$ and $\mathrm{Si}(111)\sqrt{21}\ifmmode\times\else\texttimes\fi{}\sqrt{21}\ensuremath{-}(\mathrm{Ag}+\mathrm{Au}).$ For $\mathrm{Si}(111)\sqrt{3}\ifmmode\times\else\texttimes\fi{}\sqrt{3}\ensuremath{-}\mathrm{Ag}$ the Fermi surface consists of small electron pockets populated by electrons from a few % excess Ag. For $\mathrm{Si}(111)\sqrt{21}\ifmmode\times\else\texttimes\fi{}\sqrt{21}\ensuremath{-}(\mathrm{Ag}+\mathrm{Au})$ the pockets increase their size corresponding to a filling by three electrons per unit cell. The $\sqrt{21}\ifmmode\times\else\texttimes\fi{}\sqrt{21}$ superlattice leads to an intricate surface umklapp pattern and to minigaps of 110 meV, giving an interaction potential of 55 meV for the $\sqrt{21}\ifmmode\times\else\texttimes\fi{}\sqrt{21}$ superlattice.
Weaning very low birthweight infants from mechanical ventilation using intermittent mandatory ventilation and theophylline. (1979)

Correspondence 81 (Wagenvoort and Planten, 1954; Staubesand, 1955) produced morphological evidence that they were artefacts and that they resulted from invaginations of the arterial wall when tissues are stretched and then cut. This may happen during surgery as well as at necropsy. Moffat (1956) produced these changes, which are identical with those described by Salisbury and Keeling, experimentally.
Molecular dynamics simulation of nerve agent-sorbent binding (2019)

Molecular dynamics (MD) simulations of nerve agent-sorbent binding are presented for interpretation of infrared molecular binding spectroscopy, which is for nerve agent detection. Potential-energy-function parameters for the MD simulations are adjusted according to attenuated total reflection (ATR) measurements of surface interaction between a custom sorbent material and nerve agent simulant. The physical assumptions underlying these MD simulations and sensitivity of potential-function parameters are examined with respect to viability for quantitative prediction and interpretation of ATR spectra associated with nerve agent detection.
Immunohistochemical Investigations on External Auditory Canal Cholesteatomas (2003)

These results suggest that similar to the middle ear cholesteatoma, a chronic inflammatory process underlies the EACC, and the inflammatory stimuli may alter keratinocyte proliferation.
The effect of added proteolytic enzymes on meltability of Mozzarella cheese manufactured by ultrafiltration (1998)

Four proteolytic enzymes (Neutrase'", Bacillus licheniformis proteinase (BLP), porcine trypsin (PT), and Fusarium oxysporum proteinase (FDT were evaluated in Mozzarella cheese manufactured by ultrafiltration (UF). The UF Mozzarella cheese had impaired melting behaviour due to the incorporation of whey protein into the cheese curd. PT and FDT had no activity during incubation and storage. The melting 10 % diameter expansion (DE and sensoric behaviour of these cheeses were similar to the control UF Mozzarella without enzyme addition. Cheeses with Neutrase' showed very strong proteolytic activity and increased non-coagulable nitrogen (NCN) to > 50 % after 5 weeks. DE was -45 %, but a very bitter off taste was found. BLP increased proteolysis NCN -30 %), and the DE was -25 % without any off flavours. Acceleration of proteolysis in UF Mozzarella by enzyme addition generally improved the meltability due to increased casein degradation, while whey protein was resistant to proteolysis. InralElsevier, Paris. ultrafiltration / Mozzarella cheese / proteinase / proteolysis / meltability Rsum -Effet des enzymes protolytiques sur la capacit de fonte du fromage mozzarella produit par ultrafiltration. Quatre enzymes protolytiques (Neutrase'", protase de Bacillus licheniformis (BLP), trypsine porcine (PT) et protase de Fusarium oxysporum (FDT) ont t evalues dans un fromage mozzarella produit par ultrafiltration (UF). La mozzarella obtenue par UF avait une aptitude rduite la fonte, du fait de l'incorporation des protines sriques dans le caill. La PT et la FDT n'ont montr aucune activit durant l'acidification et l'affinage. L'aptitude l'ta-Iement 10 % d'largissement du diamtre, DE) et les proprits sensorielles de ces fromages taient identiques celles de l'chantillon tmoin (mozzarella UF sans ajout d'enzyme). Les fromages additionns de Neutrasef prsentaient une protolyse accrue et une augmentation de l'azote non coagulable (NCN), de plus de 50 % aprs 5 semaines d'affinage. Le DE tait d'envi-* Correspondence and reprints 259 1.S. Madsen et al. ron 45 %, mais un got trs amer s'est developp paralllement. La BLP a montr une augmentation de la protolyse (NCN -30 %), et le DE tait d'environ 25 %, sans qu'aucun mauvais got ne soit dtect. L'acclration de la protolyse dans l'UF mozzarella par l'addition des enzymes a amlior la capacit de fonte, due une dgradation acclre de la casine, tandis que les protines sriques taient rsistantes la protolyse.
Unveiling the Chemical Composition of Sugar Cane Biocrudes by Liquid Chromatography–Tandem Mass Spectrometry (2015)

Sugar cane biomass is a rich and powerful source of carbon atoms for renewable fuel generation. However, its efficient introduction into the standard refinery installations is still a challenge. Recently, we have shown the possibility to produce gasoline compounds through refinery-friendly biocrudes obtained by one-pot hydrolysis–ketalization reaction of second-generation sugar cane biomass. Herein, we describe the development and validation of a liquid chromatography–triple quadruple mass spectrometry (LC–MS/MS) method to quantify four carbohydrate-derived O-isopropylidene ketals present in biocrudes obtained by different reaction conditions and also the identification of six other compounds based on MS/MS fragmentation experiments. The validated method was selective, precise, accurate, and linear over the range of 0.2–25 μg mL–1, with correlation coefficient values higher than 0.99. The reaction carried out at 90 °C for 3 h resulted in a biocrude with 34.2% (w/w) of biomass conversion and 38.1% formation of the monitored O-isopropylidene ketals, with xylose diacetonide being the most abundant and rapidly formed compound. In addition, disaccharides of pentose and pentose–hexose containing from one to three O-isopropylidene units have been identified. This LC–MS/MS analysis permitted a better understanding of the chemical composition of biocrudes and, therefore, could remarkably improve the possibility of tailor-made biocrudes in function of the regular refinery process.