gebhart/patrepeval huggingface dataset:
Dynamic Acetylation of All Lysine 4–Methylated Histone H3 in the Mouse Nucleus: Analysis at c-fos and c-jun (2005)

A major focus of current research into gene induction relates to chromatin and nucleosomal regulation, especially the significance of multiple histone modifications such as phosphorylation, acetylation, and methylation during this process. We have discovered a novel physiological characteristic of all lysine 4 (K4)-methylated histone H3 in the mouse nucleus, distinguishing it from lysine 9-methylated H3. K4-methylated histone H3 is subject to continuous dynamic turnover of acetylation, whereas lysine 9-methylated H3 is not. We have previously reported dynamic histone H3 phosphorylation and acetylation as a key characteristic of the inducible proto-oncogenes c-fos and c-jun. We show here that dynamically acetylated histone H3 at these genes is also K4-methylated. Although all three modifications are proven to co-exist on the same nucleosome at these genes, phosphorylation and acetylation appear transiently during gene induction, whereas K4 methylation remains detectable throughout this process. Finally, we address the functional significance of the turnover of histone acetylation on the process of gene induction. We find that inhibition of turnover, despite causing enhanced histone acetylation at these genes, produces immediate inhibition of gene induction. These data show that all K4-methylated histone H3 is subject to the continuous action of HATs and HDACs, and indicates that at c-fos and c-jun, contrary to the predominant model, turnover and not stably enhanced acetylation is relevant for efficient gene induction.
Study on Standardization of Detection Data of Atmospheric Microparticle Lidar Based on Metadata (2018)

Decentralized original and disordered management of atmospheric lidar data are seriously obstructing regional atmospheric environment research. Though the analysis of the characteristics of atmospheric lidar data in this paper, it shows that it is very necessary to create the data standard based on metadata. After the analysis of the basic functions and the main content of the atmospheric lidar metadata standard, it gives a descriptive method and atmospheric lidar metadata model to based on meteorological metadata standard.
Eating Serial: Beatrice Lindsay, Vegetarianism, and the Tactics of Everyday Life in the Late Nineteenth Century (2015)

This paper derives from research I conducted in the archives of the Vegetarian Society, in Manchester, in October 2011 on the figure of Beatrice Lindsay, a graduate from Girton College, Cambridge, who, in 1885, became the first female editor of the Society’s journal, the Dietetic Reformer and Vegetarian Messenger. In addition to her position as editor, Lindsay contributed a monthly column on “New Foods” in which she displayed her fluency with scientific terminology not simply to advocate the vegetarian diet, but to make the diet practicable for readers. I argue that her column uses the serial form of the periodical, which presents novel content within a regular structure, to shape inchoate vegetarianism: she gradually constituted the emerging diets, habits, and bodies of vegetarians by, each month, introducing readers to novel content (“new foods”) within a recurrent form.
Chapter A6. Section 6.1. Temperature (2006)

For additional information, contact: Water Mission AreaU.S. Geological Survey12201 Sunrise Valley DriveReston, VA 20192Email: nfm@usgs.gov Accurate temperature measurements are required for accurate determinations of important environmental parameters such as pH, specific electrical conductance, and dissolved oxygen, and to the determination of chemical reaction rates and equilibria, biological activity, and physical fluid properties. This section of the National Field Manual (NFM) describes U.S. Geological Survey (USGS) guidance and protocols for measurement of temperature in air, ground water, and surface water and calibration of the equipment used. Each chapter of the National Field Manual is published separately and revised periodically. Newly published and revised chapters will be announced on the USGS Home Page on the World Wide Web under 'New Publications of the U.S. Geological Survey.'
Prospettive terapeutiche nella cura del morbo di Addison (2013)

In questo editoriale sono valutate e analizzate alcune applicazioni terapeutiche innovative che potrebbero permettere un nuovo e differente approccio alla cura del morbo di Addison. Sebbene le conoscenze relative a questa malattia siano ancora limitate, soprattutto a causa della sua rarità, i principali meccanismi patogenetici del morbo sono qui valutati nell'ottica di capire quali potrebbero essere le future strategie terapeutiche per la cura di questa patologia. Attraverso l'analisi delle questioni di natura genetica e immunologica che caratterizzano l'Addison e cercando di comprendere quale potrebbe essere il ruolo delle cellule staminali adrenocorticali nella rigenerazione delle funzioni ghiandolari, sono, infine, riportati due studi clinici e alcune possibilità terapeutiche che potrebbero cambiare profondamente l'approccio a tale patologia.
Fundamental Bounds for Sequence Reconstruction From Nanopore Sequencers (2016)

Nanopore sequencers are emerging as promising new platforms for high-throughput sequencing. As with other technologies, sequencer errors pose a major challenge for their effective use. In this paper, we present a novel information theoretic analysis of the impact of insertion-deletion (indel) errors in nanopore sequencers. In particular, we consider the following problems: (i) for given indel error characteristics and rate, what is the probability of accurate reconstruction as a function of sequence length; (ii) using replicated extrusion (the process of passing a DNA strand through the nanopore), what is the number of replicas needed to accurately reconstruct the true sequence with high probability? Our results provide a number of important insights: (i) the probability of accurate reconstruction of a sequence from a single sample in the presence of indel errors tends quickly (i.e., exponentially) to zero as the length of the sequence increases; and (ii) replicated extrusion is an effective technique for accurate reconstruction. We show that for typical distributions of indel errors, the required number of replicas is a slow function (polylogarithmic) of sequence length - implying that through replicated extrusion, we can sequence large reads using nanopore sequencers. Moreover, we show that in certain cases, the required number of replicas can be related to information-theoretic parameters of the indel error distributions.
Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit (1991)

Mice with W mutations characterized by hypopigmentation, sterility, anemia, and mast cell deficiency have abnormalities in c-kit, a receptor with tyrosine kinase activity. Recently, the ligand for c-kit was cloned by investigators in several laboratories. Zsebo et al identified and cloned a gene for a cytokine termed stem cell factor (SCF) in the medium conditioned by buffalo rat liver cells, and this cytokine proved to be c-kit ligand. We have examined the effects of recombinant rat SCF (rrSCF) on colony formation from primitive hematopoietic progenitors in culture. rrSCF and erythropoietin (Ep) supported formation of granulocyte/macrophage (GM) colonies as well as a small number of multilineage and blast cell colonies from marrow cells of normal mice. We then examined the effects of rrSCF using marrow and spleen cells of mice that had been treated with 150 mg/kg 5- fluorouracil (5-FU). Unlike single factors, combinations of factors such as rrSCF plus interleukin-3 (IL-3), rrSCF plus IL-6, and rrSCF plus granulocyte colony-stimulating factor (G-CSF) markedly stimulated the growth of multilineage colonies. In contrast to these factor combinations and a combination of IL-3 and IL-6, a combination of rrSCF and IL-4 did not support multilineage colony formation. Mapping studies of the development of multipotential blast cell colonies further indicated that rrSCF, like IL-6, G-CSF, and IL-11, shortens the dormant period in which the stem cells reside. When we tested the effects of rrSCF using pooled blast cells, which are highly enriched for progenitors and are devoid of stromal cells, rrSCF plus Ep supported formation of only a few multilineage colonies, indicating that rrSCF itself is ineffective in support of the proliferation of multipotential progenitors. However, rrSCF supported formation of a significant number of neutrophil and neutrophil/macrophage colonies from pooled blast cells, indicating that rrSCF is able to support directly the proliferation of progenitors in neutrophil/monocyte lineages. c-kit ligand may play important roles in adult hematopoiesis.
Titanium Nitride Coating of RF Ceramic Windows by Reactive DC Magnetron Sputtering (2008)

International audience
Hyperhidrosis treated by thoracoscopic sympathicotomy (1996)

Hyperhidrosis of the palms, axillae and face has a strong negative impact on social and professional life. The existing non-operative therapeutic options seldom give sufficient relief and have a transient effect. A definitive cure can be obtained by upper thoracic sympathectomy. The traditional open surgical techniques are major procedures and few patients and surgeons have found that the risk--benefit consideration favoured surgery. Since 1987, the authors have divided the upper thoracic sympathetic chain on 1163 patients with a simple endoscopic technique by using standard urological equipment. A bilateral procedure takes less than 20 min and requires just one night in hospital. There have been no mortality or life-threatening complications. Ten patients (< 1%) required intercostal drainage because of haemo- or pneumothorax. Horner's syndrome occurred in four cases. Primary failure occurred in 23 cases (< 2%) and 24 (< 2%) developed recurrent symptoms. The patients with failure and recurrence were successfully reoperated on and only three have required a third operation. At the end of postoperative follow-up (median 31 months) 98% of the patients were satisfied. Endoscopic transthoracic sympathicotomy is an efficient, safe and minimally invasive surgical method for the treatment of palmar, axillary and facial hyperhidrosis.
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents (2013)

Iron plays a vital role in the normal functioning of cells via the regulation of essential cellular metabolic reactions, including several DNA and histone-modifying proteins. The metabolic status of iron and the regulation of epigenetic mechanisms are well-balanced and tightly controlled in normal cells; however, in cancer cells these processes are profoundly disturbed. Cancer-related abnormalities in iron metabolism have been corrected through the use of iron-chelating agents, which cause an inhibition of DNA synthesis, G₁-S phase arrest, an inhibition of epithelial-to-mesenchymal transition, and the activation of apoptosis. In the present study, we show that, in addition to these well-studied molecular mechanisms, the treatment of wild-type TP53 MCF-7 and mutant TP53 MDA-MB-231 human breast cancer cells with desferrioxamine (DFO), a model iron chelator, causes significant epigenetic alterations at the global and gene-specific levels. Specifically, DFO treatment decreased the protein levels of the histone H3 lysine 9 demethylase, Jumonji domain-containing protein 2A (JMJD2A), in the MCF-7 and MDA-MB-231 cells and down-regulated the levels of the histone H3 lysine 4 demethylase, lysine-specific demethylase 1 (LSD1), in the MDA-MB-231 cells. These changes were accompanied by alterations in corresponding metabolically sensitive histone marks. Additionally, we demonstrate that DFO treatment activates apoptotic programs in MCF-7 and MDA-MB-231 cancer cells and enhances their sensitivity to the chemotherapeutic agents, doxorubicin and cisplatin; however, the mechanisms underlying this activation differ. The induction of apoptosis in wild-type TP53 MCF-7 cells was p53-dependent, triggered mainly by the down-regulation of the JMJD2A histone demethylase, while in mutant TP53 MDA-MB-231 cells, the activation of the p53-independent apoptotic program was driven predominantly by the epigenetic up-regulation of p21.
A low-complexity antenna diversity receiver suitable for TDMA handset implementation (2002)

This paper introduces a low-complexity antenna diversity receiver suitable for TDMA handset implementation. The receiver employs two branches of diversity, and is capable of adaptively choosing among three different diversity techniques which are implemented in a single design which we refer to as a multi-diversity receiver. It consists of a single conventional wireless digital receiver chain augmented with a few additional low-cost passive RF components and minor control circuits. We present algorithms for efficient co-phasing and equal-gain combining, as well as a novel cochannel interference-reduction combining algorithm. These are implemented in a system design simulation which conforms to the PACS (Personal Access Communication System) standard. We then present simulation link performance for selection diversity (SD), equal-gain combining (EGC) and interference-reduction combining (IRC) under Raleigh fading, flat fading with cochannel interference and selective fading conditions. The results show that EGC and IRC yield a signal-to-noise ratio (SNR) improvement of 1 dB and a signal-to-interference ratio (SIR) improvement 4 dB-/spl sim/5.5 dB, respectively, compared with SD. The receiver also lowers the irreducible word error rate due to multipath delay spread when the Doppler shift is small. These results are compared with the results from other research.
Pediatric Injuries in the Back of Pickup Trucks (1990)

Travel in the back of pickup trucks has not been adequately addressed as an occupant protection issue. This study compares injuries sustained by children riding in the back of pickup trucks with those of children riding in the cab. Data were obtained from a multihospital monitoring system and the coroner in a single urban county. The series of injured children consisted of 290 children 0 through 14 years of age, 201 of whom had been riding in the cab and 89 in the back. Age distribution of the children demonstrated that it is most frequently the 10- to 14-year-olds who travel in the back. Children riding in the back were more frequently injured in noncrash events (absence of a collision), had more ejections, had more injuries, and sustained more severe injuries as measured by the Maximum Injury Score. With increased restraint use in the cab, it is likely that even greater differentials in injury severity and patterns would be realized. Education regarding the hazards of travel in the back of pickups and stronger legislation limiting the transport of children in the back of trucks are recommended.
S-Match: an algorithm and an implementation of semantic matching (2005)

We think of Match as an operator which takes two graph-like structures and produces a mapping between those nodes of the two graphs that correspond semantically to each other. Semantic matching is a novel approach where semantic correspondences are discovered by computing and returning as a result, the semantic information implicitly or explicitly codified in the labels of nodes and arcs. In this paper we present an algorithm implementing semantic matching, and we discuss its implementation within the S-Match system. We also test S-Match against three state of the art matching systems. The results, though preliminary, look promising, in particular for what concerns precision and recall.
Recent Progress on Single Photon and Positron Emission Tomography - From Detectors to Algorithms - (1987)

In the last few years, great efforts have been made to achieve higher sensitivity, higher spatial resolution, better image quality and quantification. In the SPECT, collimators and scanning methods have been improved. 180° sagittal scan is proposed for brain imaging. Practical correction methods for uniform attenuation are compared from a view point of noise propagation. In the PET system, current status of TOF-PET, high resolution PET are reviewed. CsI(Br) scintillator is a candidate of a new PET detector. For stationary PET using discrete detectors, an iterative method is preferable for the image reconstruction, because it does not need to satisfy the conventional sampling requirement for projections. Recent ECT technology tends to be sophisticated both in data acquisition and processing. It needs more powerful and versatile algorithms. Iterative reconstruction methods should be reconsidered as a tool of routine use. The EM algorithm is attractive, but it seems to need a trick to accelerate the convergence. A fast maximum likelihood algorithm is proposed, which can provide satisfactory images by a few iterations.
Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients. (2003)

Medulloblastoma is the most common malignant brain tumor in children. Although the prognosis has improved considerably, leptomeningeal spread of the tumor remains a significantly negative predictor of survival. Mitochondrial DNA (mtDNA) mutations have been detected in many types of human tumors but not in medulloblastomas. Using temporal temperature gradient gel electrophoresis, we have analyzed the entire mitochondrial genome in 15 cases of medulloblastoma and the corresponding cerebrospinal fluid (CSF) samples in 8 of 15 cases. Six of 15 cases (40%) showed at least one mtDNA mutation in each of the tumors. A total of 18 somatic mtDNA mutations was detected with one of the tumors having 11 mutations, of which 9 were novel. Seven of 8 CSF samples that were analyzed showed mtDNA mutations. One patient who showed persistent mtDNA mutation in the CSF collected at the end of therapy when there was no evidence of disease had a relapse 5 months later. In contrast, patients whose end-of-therapy CSF samples that showed either no detectable mtDNA mutation or different mutations from that of the tumor continue to be disease free. Our results demonstrate that mtDNA mutations are frequently found in medulloblastomas. The mtDNA alterations detected in CSF may be used as sensitive markers to monitor disease progression and predict relapse.
Polymer additives: Part I. Mechanical property modifiers (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymer additives: Part I. Mechanical property modifiersMalcolm P. Stevens Cite this: J. Chem. Educ. 1993, 70, 6, 444Publication Date (Print):June 1, 1993Publication History Received3 August 2009Published online1 June 1993Published inissue 1 June 1993https://doi.org/10.1021/ed070p444RIGHTS & PERMISSIONSArticle Views672Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
Infrared array photometry of bulge globular clusters. I. Combined ground based JK and HST VI photometry of NGC 6553 (1998)

JK infrared photometry for the bulge globular cluster NGC 6553, combined with high resolution visual VI observations are presented and discussed in connection with the bulge metal rich population. The infrared data were taken with IRAC2 at ESO 2.2m telescope while the optical counterparts are from Hubble Space Telescope (HST). We nd a mean magnitude for the horizontal branch of VHB = 16.92, and KHB = 12.42 ± 0.01. Assuming a reddening of E(B − V) = 0.7, the mean distance modulus is (m − M)0 = 13.6 giving an heliocentric distance of 5.2 Kpc. This distance is slightly higher than that previously published by Ortolani et al. (1990, hereafter OBB90). The brightest giants have been detected at K ~ 6.5 and (V −K) = 13.10 transforming to MK = −7.34 and (V−K)0 = 11.20, which are exceptionally high values for a globular cluster. The metallicity has been found to be consistent with previous values and an average of [Fe/H] = −0.22±0.05 has been adopted. The helium abundance estimated via the R' method yields Yp ~ 0.28 ± 0.03.
Design and performance of the Dawning Cluster File System (2003)

Cluster file system is a key component of system software of clusters. It attracts more and more attention in recent years. In this paper, we introduce the design and implementation of DCFS (the Dawning Cluster File System) - a cluster file system developed for Dawning4000-L. DCFS is a global file system sharing among all cluster nodes. Applications see a single uniform name space, and can use system calls to access DCFS files. The features of DCFS include its scalable architecture, metadata policy, server-side optimization, flexible communication mechanism and easy management. Performance tests of DCFS on Dawning4000-L show that DCFS can provide high aggregate bandwidth and throughput.
Fast Feature Selection from Microarray Expression Data via Multiplicative Large Margin Algorithms (2003)

New feature selection algorithms for linear threshold functions are de-scribed which combine backward elimination with an adaptive regular-ization method. This makes them particularly suitable to the classifica-tion of microarray expression data, where the goal is to obtain accurate rules depending on few genes only. Our algorithms are fast and easy to implement, since they center on an incremental (large margin) algorithm which allows us to avoid linear, quadratic or higher-order programming methods. We report on preliminary experiments with five known DNA microarray datasets. These experiments suggest that multiplicative large margin algorithms tend to outperform additive algorithms (such as SVM) on feature selection tasks. 1
Trends in Banking 2017 and onwards (2017)

The changing nature of the relationship between a retail bank and its customers is examined, particularly with respect to new financial concepts, debt and regulation. The traditional image of a bank is portrayed as a physical building a classical Doric portico. This image conveys concepts of service, soundness, strength, stability and security ("five-S"). That "five-S" concept is changing, and the evidence for changes that affect customers directly is considered. A fundamental legal problem associated with those changes is highlighted: a bank is no longer solely responsible for the safeguard of customer monies. A solution to this problem is proposed: banks should be jointly liable with perpetrators of criminal activity in the event of frauds as an encouragement to recognise and mitigate fraud.