gebhart/patrepeval huggingface dataset:
[Control of the ancylostomiasis infection by massive drug therapy treatment in Costa Rica]. (1972)

Tetrachloroethylene administrared to a population og 600 persons on a coffee plantation, San Jose, Costa Rica, in four doses six weeks apart, and subsequently in yearly doses during the following four, reduced the pre-valence of hookworn from 56% to 8%.
Rapid and practical synthesis of (−)-1-deoxyaltronojirimycin (2010)

Herein a practical and scalable route to 1-deoxyaltronojirimycin is presented. The target is achieved in 9 steps and 43% yield featuring only two chromatographic purifications.
Artificial intelligence and the future (2003)

We consider some of the ideas influencing current artificial-intelligence research and outline an alternative conceptual framework that gives priority to social relationships as a key component and constructor of intelligent behaviour. The framework starts from Weizenbaum's observation that intelligence manifests itself only relative to specific social and cultural contexts. This is in contrast to a prevailing view, which sees intelligence as an abstract capability of the individual mind based on a mechanism for rational thought. The new approach is not based on the conventional idea that the mind is a rational processor of symbolic information, nor does it require the idea that thought is a kind of abstract problem solving with a semantics that is independent of its embodiment. Instead, priority is given to affective and social responses that serve to engage the whole agent in the life of the communities in which it participates. Intelligence is seen not as the deployment of capabilities for problem solving, but as constructed by the continual, ever-changing and unfinished engagement with the social group within the environment. The construction of the identity of the intelligent agent involves the appropriation or 'taking up' of positions within the conversations and narratives in which it participates. Thus, the new approach argues that the intelligent agent is shaped by the meaning ascribed to experience, by its situation in the social matrix, and by practices of self and of relationship into which intelligent life is recruited. This has implications for the technology of the future, as, for example, classic artificial intelligence models such as goal-directed problem solving are seen as special cases of narrative practices instead of as ontological foundations.
Segmentation de nuage de points 3D pour la modélisation automatique d'environnements industriels numérisés (2002)

The context of this work is the 'As-built' CAD modeling of digitized industrial structures. The existing environment is first digitized using a 3D laser scanner. The data obtained this way consist of an unorganized and inhomogeneous 3D point cloud. The next step is the segmentation of this cloud and the reconstruction of the various surfaces constituting the CAD model of the scene. Industrial environments yield scenes that are complex with respect to the size of data and the number of objects, but that can be described with simple geometric primitives: the plane, the sphere, the cylinder, the cone, the torus. The current tools that process 3D point clouds are not able to perform this segmentation task automatically. <br /><br />In this project, algorithms have been developed for this purpose. We have particularly focused on the segmentation of pipelines. The software solutions implemented have been validated through tests involving users of the current tools. The main feature of the methods developed is the use, throughout the segmentation process, of constrained geometric primitives. The corresponding constraints are derived from a ground knowledge of the environment (e.g., continuity or tangency relationships). Geometric primitive fitting is a key topic in this work. The algorithms developed, which use a truly geometric definition of the primitives, show good results and performance on real scenes. Moreover, one of the major issue is then the validation of the fitted model. We hence have examined this question and given original methods based on statistics. Another contribution of this work relies in the algorithms for extracting a primitive from a point cloud. These methods have been applied in the context of pipelines, but seem to be relevant in the more general question of totally automatic modeling of digitized environments.
Salivary fistula: Blue dye testing as part of an algorithm for early diagnosis (2017)

3.
Cathepsin D from the Hepatopancreas of the Cuttlefish (Sepia officinalis): Purification and Characterization (2010)

Cathepsin D from the hepatopancreas of cuttlefish ( Sepia officinalis ) was purified to homogeneity by precipitation with ammonium sulfate (30-60%, w/v), Sephadex G-100 gel filtration, Mono-S cation-exchange chromatography, Sephadex G-75 gel filtration, and Mono-S FPLC with a 54-fold increase in specific activity and 17% recovery. The molecular weight of the purified cathepsin D was estimated to be 37.5 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). On the basis of the native-PAGE and hemoglobin zymography, the purified protease appeared as a single band. The optimum pH and temperature for the cathepsin D activity were pH 3.0 and 50 °C, respectively, using hemoglobin as a substrate. The purified enzyme was completely inhibited by pepstatin A; however, no inhibition was observed with phenylmethylsulfonyl fluoride and ethylenediaminetetraacetic acid. Moreover, the activity was strongly inhibited by SDS and molybdate and enhanced by ATP. The purified cathepsin D was activated by Mg(2+), Ni(2+), Zn(2+), Cu(2+), Cd(2+), Sr(2+), and Co(2+) ions, whereas it was not affected by Na(+), K(+), and Ca(2+) ions. The N-terminal amino acid sequence of the first 13 amino acids of the purified cathepsin D was APTPEPLSNYMDA. S. officinalis cathepsin D, which showed high homology with cathepsin D from marine vertebrates and invertebrates, had a Pro residue at position 6 and a Ser residue at position 8, where Thr and Lys are common in all marine vertebrates cathepsins D. S. officinalis cathepsin D showed high efficiency for the hydrolysis of myofibrillar proteins extracted from cuttlefish muscle.
Electronic properties of polymers based on thienothiadiazole and thiophene (1996)

Ab initio crystal orbital (CO) studies on the geometric and the electronic structures of poly(thienothiadiazole) (Poly-1a) and periodic copolymers of thienothiadiazole and thiophene with the ratio of 1:1 (Poly-2b) and 1:2 (Poly-3b) are presented. In Poly-1a and Poly-2b, considerable change in the geometries is found to occur as one moves from their oligomers to the polymers. Although thienothiadiazole oligomers have a very small highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) separation, the corresponding polymer (Poly-1a) has a considerably large band gap. On the contrary, the geometric and electronic structures of Poly-3b are almost identical to those of the oligomer, and Poly-3b possesses a direct band gap of 1.3 eV estimated by simple scaling. The reasons for these differences are discussed in terms of orbital interactions and nonbonding molecular orbitals in the oligomers, and the reduced π-conjugation and enhanced intercell interaction in the polymers.
Macrolide-Resistance Genes in Clinical Isolates of <i>Streptococcus pyogenes</i> (2002)

Macrolide-resistance genes were investigated in 103 macrolide-resistant strains of Streptococcus pyogenes, isolated from children with pharyngotonsillitis. The presence of mef(A), erm(B), and erm(TR) genes was detected by PCR. mef(A) was found in 48 out of 103 (46.6%) strains, whereas erm(B) was detected in 43 isolates (41.7%). All mef(A) strains showed a typical M phenotype (resistance to 14- and 15-membered macrolides, and sensitivity to lincosamides and streptogramin B), whereas erm(B) strains had the MLSB phenotype (resistance to macrolides, lincosamides, and streptogramin B antibiotics). erm(TR) was found in 10 strains, always together with other resistance genes. In seven cases erm(TR) was associated with erm(B), and three cases with mef(A). In two isolates with the M phenotype (1.9%), it was not possible to detect the presence of any of the three macrolide resistance genes tested. Inducible resistance to macrolides was shown for 24 out of the 53 MLSB strains. Analysis of macrorestriction fragment patterns by pulsed-field gel electrophoresis showed that erythromycin-resistant S. pyogenes are polyclonal, however each phenotype, MLSB and M, formed essentially homogeneous groups.
Metabolic Syndrome and the Risk of Stroke in Middle-Aged Men (2006)

The risk of any stroke is increased in men with metabolic syndrome, in the absence of stroke, diabetes and cardiovascular disease at baseline. Prevention of the metabolic syndrome presents a great challenge for clinicians with respect to stroke.
Microbiological Assay for Pantothenic Acid (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrobiological Assay for Pantothenic AcidF Strong, R Feeney, and Ann EarlerCite this: Ind. Eng. Chem. Anal. Ed. 1941, 13, 8, 566–570Publication Date (Print):August 1, 1941Publication History Published online1 May 2002Published inissue 1 August 1941https://pubs.acs.org/doi/10.1021/i560096a020https://doi.org/10.1021/i560096a020research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
INFLAMMATION IMAGING WITH A Tc-99m-LABELLED TUFTSIN ANTAGONIST (1995)

Tran, L. L.P.; Lau, F.; Eriksson, S.; Ballinger, J.; Pollak, A.; Goodbody, A. E. Author Information
Multiple Matched Spatial Filtering with Corresponding Symbols by the Hybrid System (1990)

A system for multiple pattern recognition without observing peak autocorrelation signals is described. A multiplexed matched spatial filter is used for multiple operations. The reconstructed peak signals are not directly used for recognition. They are first fed into a frame buffer memory via a CCD camera to be processed by a microcomputer. Unknown inputs are finally recognized by taking a glance at symbols, which are displayed on a CRT screen and are deduced from the peak signals by the microcomputer. The system presents easier recognition for observers who are not expert in matched filtering.
Some Compounds Inhibited the Determination of Ascorbic Acid by Isotachoelectrophoresis (1979)

前報においてAsAの定量法として細管式等速電気泳動法が応用できることを報告したので, 本報では食品中のAsAを実際に測定し, その実用性を検討した。その結果以下のことが認められた。1) 試料の抽出には2%チオ尿素-0.01N塩酸を用いるとき, 回収率もよく短時間に泳動が終了することを認めた。2) β-アラニン系リーディング液 (pH 3.6) の条件では食品中のAsAはGluとミックスゾーンを形成し測定が不可能となるが, このミックスゾーンは, α-ナフチルアミン系リーディング液 (pH 2.5) では, 分離できることを確かめた。なおβ-アラニン系リーディング液 (pH 3.6) の場合にも電位勾配検出器による同定と254nmにおける紫外部吸収を求める紫外部吸光検出器による定量を併用することによってAsAの定量は可能であることを確認した。3) AsAとAAsAの分離は電位勾配検出器, 紫外部吸光検出器のいずれを用いても成功しなかった。
A sensitive and specific precursor ion scanning approach in liquid chromatography/electrospray ionization tandem mass spectrometry to detect methylprednisolone acetate and its metabolites in rat urine (2010)

A new, simple, sensitive and specific liquid chromatography/electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS) method in precursor ion scanning (PIS) mode has been developed for the rapid detection of methylprednisolone acetate (MPA) and its metabolites in rat urine. A suitable product ion specific for methylprednisolone (MP) and MPA was selected after a fragmentation study on 20 (cortico)steroids at different collision energies (5-40 eV). Urine samples were simply treated with acetonitrile then dried in a SpeedVac system. The method was validated and compared with other PIS methods for detecting corticosteroids in human urine. It was more sensitive, with limit of detection (LOD) and lower limit of quantitation (LLOQ), respectively, of 5 and 10 ng mL(-1). The method was applied for the analysis of rat urine collected before and after (24, 48, 72 h) intra-articular (IA) injection of a marketed formulation of MPA (Depo-Medrol(R)). MS/MS acquisitions were taken at different collision energies for the precursor ions of interest, detected in PIS mode, to verify the MP-related structure. Six different metabolites were detected in rat urine, and their chemical structures were assigned with a computational study.
ChemInform Abstract: SYNTHESIS OF α‐METHYLENE LACTONES BY REDUCTIVE AMINATION OF α‐FORMYL LACTONES. SCOPE AND LIMITATIONS (1976)

Abstract Verschiedene Verfahren zur Umwandlung der Lactone (Ia)‐(IVa) in die α‐Methylen‐Verbindungen (Id)‐(IVd) werden diskutiert, wobei die entsprechenden Formylverbindungen (b‐Reihe),die Zwischenstufenbei der Reaktion sind,hergestellt werden.
A Negative-TC Controllable Voltage Reference Using MOS PTAT (2007)

A voltage reference having a maximum TC of-0.45%/℃ is presented. The proposed scheme comprises a MOS bandgap voltage reference, a PTAT voltage reference and a voltage subtractor. This circuit is designed using a 0.18-㎛ CMOS process, whose size is 450㎛×400㎛ and power consumption is 12.3㎼ at room temperature. The proposed scheme improves immunity to both process and resistor variation by 4 times of the conventional scheme (±20% → ±5%).
Canine Pancreatic Secretion in Response to Acceptable and Aversive Taste Stimuli (1968)

SummaryThe present study, with conscious dogs, indicates that both pancreatic flow and pancreatic protein output can be affected by the nature of the taste stimuli. Water and a sucrose solution mixed with a basal diet produced a similar and significantly greater stimulation of flow than did citric acid or quinine, which in turn were similar. Although it appeared that protein secretion was more strongly enhanced by sucrose solution than by water and solutions of citric acid and quinine, it was not clearly established that sucrose solution and water were really different. The flow responses for the four taste stimuli were highly correlated with the readiness with which the various food mixtures were accepted by the dogs.
The Crystallization of Sodium Hypochlorite on Gutta-percha Cones After the Rapid-Sterilization Technique: An SEM Study (2003)

The purpose of this study was to identify the presence, crystallization, and subsequent removal of sodium hypochlorite crystals on gutta-percha cones after rapid sterilization. Seventy-two, fresh, standardized, gutta-percha cones were randomly selected. Each cone was observed under the scanning electron microscope and the elemental analysis machine before and after rapid sterilization using 5.25% and 2.5% sodium hypochlorite. Gutta-percha cones were rinsed after sterilization with 96% ethyl alcohol, 70% isopropyl alcohol, and distilled water independently to determine which of these agents removed the sodium-chloride crystals. There were no crystals present on the gutta-percha cones directly from the box. All gutta-percha cones had sodium-chloride crystals present after the rapid-sterilization technique using 5.25% and 2.5% sodium hypochlorite. However, the sodium-chloride crystals were removed by 96% ethyl alcohol, 70% isopropyl alcohol, and distilled water.
SEIMCHA: A New Semantic Image CAPTCHA Using Geometric Transformations (2012)

As protection of web applications are getting more and more important every day, CAPTCHAs are facing booming attention both by users and designers. Nowadays, it is well accepted that using visual concepts enhance security and usability of CAPTCHAs. There exist few major different ideas for designing image CAPTCHAs. Some methods apply a set of modifications such as rotations to the original image saved in the data base, to make the CAPTCHA more secure. In this paper, two different approaches for designing image based CAPTCHAs are introduced. The first one _which is called Tagging image CAPTCHA _is based on pre-tagged images, using geometric transformations to increase security, and the second approach tries to enhance the first one by eliminating the use of tags and relying on semantic visual concepts. In fact, recognition of up- right orientation is used as a visual cue. The usability of the proposed approaches is verified using human subjects. An estimation of security is also obtained by different kinds of attacks. Further studies are done on the proposed transformations and also on the properness of each original image for each approach. Results suggest a practical Semantic Image CAPTCHA which is usable and secure compared to its peers.
Predictive Control using an Observer for Load Estimation (1986)

The load responses of predictive control systems can be significantly improved by the addition of an observer for load estimation. The observer design is based on the inverse of a simplified process model. Simulation studies demonstrate that the proposed design method results in predictive controllers with load estimation which are superior to both existing predictive controllers and conventional PID control1ers.
Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus (1995)

The matrix (M1) protein of influenza virus is a major structural component, involved in regulation of viral ribonucleoprotein transport into and out of the nucleus. Early in infection, M1 is distributed in the nucleus, whereas later, it is localized predominantly in the cytoplasm. Using immunofluorescence microscopy and the influenza virus mutant ts51, we found that at the nonpermissive temperature M1 was retained in the nucleus, even at late times after infection. In contrast, the viral nucleoprotein (NP), after a temporary retention in the nucleus, was distributed in the cytoplasm. Therefore, mutant M1 supported the release of the viral ribonucleoproteins from the nucleus, but not the formation of infectious virions. The point mutation in the ts51 M1 gene was predicted to encode an additional phosphorylation site. We observed a substantial increase in the incorporation of 32Pi into M1 at the nonpermissive temperature. The critical role of this phosphorylation site was demonstrated by using H89, a protein kinase inhibitor; it inhibited the expression of the mutant phenotype, as judged by M1 distribution in the cell. Immunofluorescence analysis of ts51-infected cells after treatment with H89 showed a wild-type phenotype. In summary, the data indicated that the ts51 M1 protein was hyperphosphorylated at the nonpermissive temperature and that this phosphorylation was responsible for its aberrant nuclear retention.
Acute Disseminated Encephalomyelitis: Idiopathic, Post‐infectious, and Post‐vaccination (2015)

Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating disease of the central nervous system (CNS) that usually affects the very young. In most cases, ADEM follows an infection (usually viral) or an immunization (“post-infectious or post-vaccination encephalomyelitis”). Although there is a close temporal relationship to vaccinations, ADEM occurs at low incidence following immunizations and there is no concrete evidence of a clear pathogenetic correlation. Post-vaccination ADEM accounts only for 5–10% of all cases of ADEM. Since there are no strict diagnostic criteria for ADEM and there is usually a controversy between it and multiple sclerosis (MS)/clinically isolated syndrome (CIS), its actual incidence is difficult to accurately estimate. Immunological studies have investigated the presence and secretion of cytokines and chemokines in the blood and cerebrospinal fluid (CSF) of patients with ADEM. Treatments with steroids or antibody-targeting modalities usually have a favorable effect, and the prognosis is generally good.
Anti-tumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras(G12V). (1996)

We have established a syngeneic mouse tumor model to test the efficacy of the drug-sensitizing enzyme thymidine kinase from herpes simplex virus (HSVtk) in vivo. Activated mutant Ki-ras(G12V) is frequently found in human colon cancer and adenocarcinomas of the lung and pancreas. We have transformed BALB/c-3T3 cells by stable transfection of a plasmid directing the expression of the mutant Ki-ras cDNA. To transfer the HSVtk gene into tumor cells we used a Moloney murine leukemia virus (MoMLV)-based retroviral vector that carries the HSVtk gene. In this study we show that the activity of HSV-TK inhibits tumor growth in immune-compromised nude mice following GCV treatment for up to 50 days but is not sufficient to completely eliminate all tumor cells in these mice as evidenced by the occurrence of tumors between 40 and 50 days after tumor cell implantation. By contrast, immune-competent BALB/c mice develop a long-lasting antitumor immunity in response to HSVtk transduction and GCV treatment, indicating that the immune system is important for the long-term tumor suppression in vivo. In the presence of GCV co-culturing of tumor cells with HSVtk transfected cells leads to the efficient killing of HSVtk negative tumor cells. While this retroviral vector independent HSV-TK/GCV-mediated bystander effect is not sufficient to inhibit tumor formation in athymic animals it is very efficient in immune-competent syngeneic mice. Taken together the data indicate that the antitumor activity of HSV-TK is enhanced by an intact immune system.
Abstract 347: Zebrafish Insertional Cardiac (ZIC) Mutants: a Living Genomic Resource for Cardiac Biology (2013)

The human genome encodes about 20,000 genes and only a fraction of them are expressed in the heart. We hypothesized that annotation of this category of genes may facilitate our understanding of cardiac development and function. Recently, we reported a pilot insertional mutagenesis screening in zebrafish to annotate cardiac gene functions using a gene-break transposon (GBT). It demonstrated the feasibility of generation of a Zebrafish Insertional Cardiac (ZIC) mutant collection by screening gene expression in the embryonic heart. Here, we report an alternative strategy to identify cardiac mutants based on adult heart expression, and explore the application of expanded ZIC lines for understanding cardiac biology. From 203 GBT lines, we identified 34 lines with detectable expression in the dissected adult hearts. Various expression levels of the tagged genes were detected in embryonic hearts. Based on their tissue-specific expression, the candidate ZIC lines can be grouped into myocardium lines, endocardium lines, or both. Based on their subcellular expression, myocardium ZIC lines can be further categorized into sarcomeric lines, mitochondrial lines, and/or nucleic lines. Phenotypic analysis is being conducted to identify recessive mutants including embryonic lethal lines. We will present the current status of our ZIC collection, and discuss its application as a genomic resource platform for elucidating cardiac biology. Our data suggest that ~15% genes in the whole genome might have detectable cardiac expression. The sensitivity of screening for cardiac genes at adult stage is higher than that at embryonic stage (34/203 versus 18/322). We plan to expand the ZIC collection by screening 1,000 GBT lines that are being generated at Mayo Clinic. It is expected that this living mutant collection of cardiac genes will open doors to systematic annotation of novel cardiac genes and forward cardiac mutagenesis screening.