gebhart/patrepeval huggingface dataset:
Abstract 4034: DCLK1 is upregulated in melanoma and it is a novel predictive marker for survival and response (2019)

Melanoma is the deadliest form of all skin cancer, and the incidence of melanoma has been rising for the last 30 years. There are only a few reported biomarkers for prediction and prognosis for melanoma, therefore, there is an unmet medical need to identify predictive and prognostic biomarkers. Doublecortin-like kinase 1 (DCLK1) marks a population of tumor-initiating cells in colonic and pancreatic cancers, and it is overexpressed in many solid tumors. Our preliminary studies suggest that DCLK1 is overexpressed in serum samples of melanoma patients and it maybe a novel biomarker for melanoma. In this study we examined DCLK1 expression in melanoma tumor tissues and further evaluated whether its levels in serum could be quantitatively assessed in melanoma patients before and after therapy treatment. Immunohistochemistry (IHC) analysis was performed to detect DCLK1 in a tissue microarray with 60 tumor and normal adjacent tissues (NAT) from melanoma patients. ELISA assay were performed to detect DCLK1 levels in the serum samples of melanoma patients before and after treatment. Western blotting was also performed to detect DCLK1 protein in the serum samples of melanoma patients. Additionally, analysis of DCLK1 and correlative gene expressions was performed using TCGA Melanoma dataset. Here we report that the intensity of DCLK1 staining in melanoma tumor tissues are significantly increased compared to NAT. DCLK1 levels in the serum were elevated in melanoma patients (n=65) compared to healthy volunteers. Patients with higher levels of serum DCLK1 had reduced overall survival compared to patients with lower levels of serum DCLK1. We also compared DCLK1 levels in 10 patients for whom pre- and post- treatment samples were available. Among these patients, seven had elevated DCLK1 before treatment and had a significantly decrease (about 30-50%) in serum DCLK after treatment. Three patients had no change in DCLK1 levels after treatment. Interestingly, the patients with decrease level of DCLK1 post-treatment demonstrated significant clinical responses to therapy, however, the patients with no change in DCLK1 level post therapy showed no clinical improvement (p<0.002). Our study suggested that serum DCLK1 may be an independent prognostic factor, and treatment-induced reduction in serum DCLK1 was associated with excellent clinical response. These data taken together suggest that DCLK1 maybe a novel biomarker for melanoma for prognosis and response purposes.Citation Format: Dongfeng Qu, Nathaniel Weygant, Parthasarathy Chandrakesan, Kamille Pitts, Randal May, Adam Asch, Alexandra Ikeguchi, Courtney Houchen. DCLK1 is upregulated in melanoma and it is a novel predictive marker for survival and response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4034.
Identification et comptage des diverses imperfections rencontrées sur le fil de coton (1989)

Les imperfections sont à base : soit de fragments de coque, soit de fragments divers (végétaux et miellats), soit de nepsfibres (enchevêtrement de fibres). Influence de la variété, du lieu de culture, et des caractéristiques telles que finesse, maturité, seed-index, égrenage. L'identification des différents types d'imperfections est utile au sélectionneur
lgE isotype determination:  -germline gene transcription, DNA recombination and B-cell differentiation (2000)

Immunoglobulin class switching is the process which determines whether a B-cell secretes antibodies of the IgM, IgG, IgA or IgE class (or isotype). IgE is the antibody that mediates the allergic response by sensitising mast cells to allergens at the mucosal barrier. Class switching proceeds by three successive steps, culminating in the synthesis and secretion of antibody: these are germline gene transcription, DNA recombination and B-cell differentiation. We review here the present state of knowledge concerning the mechanisms involved in each of these steps, with particular reference to IgE. Intervention in the mechanisms that specify the selection of IgE may offer a means to combat allergy.
Prognostic Value of Serum Interleukin-6 in Diffuse Large-cell Lymphoma (1997)

In patients with diffuse large-cell lymphoma, serum interleukin-6 levels are an independent prognostic factor for complete response and failure-free survival.
Polihidroxialcanoati. Sinteza, structura, proprieta, caracterizare, degradare, aplicatii tehnice (1997)

International audience
Pulmonary hypertension in patients with myelofibrosis secondary to myeloproliferative diseases (1999)

We examined the clinical characteristics of six patients with myelofibrosis secondary to myeloproliferative diseases whose clinical courses were complicated by pulmonary hypertension to determine possible causal links between the two disorders. Six patients (four male, two female), with diagnoses of myeloproliferative disease, myelofibrosis (one with polycythemia vera, three with agnogenic myeloid metaplasia, one with unclassified myeloproliferative syndrome, one with essential thrombocytosis), and pulmonary hypertension are presented. Measurement of the pulmonary artery pressure was performed by Doppler echocardiography in all patients and by right sided heart catheterization in four patients. The range of resting pulmonary artery systolic pressure was 35 to 47 mmHg above the mean right atrium by echocardiography. One patient had autopsy evidence of pulmonary myeloid metaplasia and interstitial fibrosis; another had acute leukemic infiltration of the lung parenchyma. All patients had thrombocytosis; symptomatology in one patient with marked thrombocytosis improved with plateletpheresis. Two patients suffered systemic thrombosis. All patients had severe hepatomegaly. Two patients had evidence of left ventricular dysfunction. The interval between the development of dyspnea and death was less than seven months in five of the patients. A causal link between pulmonary hypertension and myelofibrosis secondary to myeloproliferative diseases is suggested for each patient. Hematopoietic infiltration of the pulmonary parenchyma, portal hypertension, thrombocytosis, hypercoagulability, and left ventricular failure may account in part for the development of pulmonary hypertension in these patients. Patients with myelofibrosis and dyspnea should have Doppler echocardiography to evaluate pulmonary artery pressures. Am. J. Hematol. 60:130–135, 1999. © 1999 Wiley-Liss, Inc.
Mobility in a large-scale WiFi network (2014)

Network management logs from a campus 802.11 network of nearly 4,500 ARUBA access points at the University of Massachusetts Amherst are presented. The processing steps to transform the logs from a series of individual network events, into user session trajectories are described and preliminary results are shown based on the user mobility characteristics. We plan to release a differentially private set of user trajectories for use by the research community which we hope can provide valuable insights into user mobility characterization.
Overproduction of a 37-kilodalton cytoplasmic protein homologous to NAD+-linked D-lactate dehydrogenase associated with vancomycin resistance in Staphylococcus aureus (1996)

We previously reported the isolation of a laboratory-derived Staphylococcus aureus mutant, 523k, that has constitutive low-level resistance to vancomycin (MIC = 5 micrograms/ml) and teicoplanin (MIC = 5 micrograms/ml) and elaborates a ca. 39-kDa cytoplasmic protein that was not detected in the parent strain 523 (MIC = 1 micrograms/ml). We have now detected the protein in strain 523 by immunoblotting with antiserum raised against the protein. Consistent with our initial observations, densitometric analysis of the immunoblots revealed an increased production of the protein in 523k compared with that of the susceptible parent 523. The 5' region of the gene encoding the protein of interest was identified by nucleotide sequencing a PCR product amplified from the genome of 523k with degenerate primers designed to encode the amino acid sequence of proteolytic peptides obtained from the protein. The remainder of the gene was identified by library screening, PCR, and nucleotide sequencing. The gene encodes a 36.7-kDa protein with homology to a family of bacterial NAD+-dependent, D-specific 2-hydroxyacid dehydrogenases which includes both D-lactate dehydrogenase and the enterococcal vancomycin resistance protein VanH and is therefore designated ddh. Increased production of the product of ddh, Ddh, was associated with increased D-lactate dehydrogenase activity in 523k, a finding which suggested that Ddh is likely to be the D-lactate dehydrogenase previously identified in S. aureus. The increased D-lactate dehydrogenase activity in strain 523k and the structural similarities among Ddh, D-lactate dehydrogenase, and VanH suggest that overproduction of Ddh might play a role in vancomycin resistance in this strain.
Perceptually Optimized ABR Ladder Generation for Web Streaming (2021)

Fast track article for IS&T International Symposium on Electronic Imaging 2021: Mobile Devices and Multimedia: Enabling Technologies, Algorithms, and Applications 2021 proceedings.
Retrotransposable Elements and Human Disease (2006)

Nearly 50% of the human genome is composed of fossils from the remains of past transposable element duplication. Mobilization continues in the genomes of extant humans but is now restricted to retrotransposons, a class of mobile elements that move via a copy and paste mechanism. Currently active retrotransposable elements include Long INterspersed Elements (LINEs), Short INterspersed Elements (SINEs) and SVA (SINE/VNTR/Alu) elements. Retrotransposons are responsible for creating genetic variation and on occasion, disease-causing mutations, within the human genome. Approximately 0.27% of all human disease mutations are attributable to retrotransposable elements. Different mechanisms of genome alteration created by retrotransposable elements include insertional mutagenesis, recombination, retrotransposition-mediated and gene conversion-mediated deletion, and 3' transduction. Although researchers in the field of human genetics have discovered many mutational mechanisms for retrotransposable elements, their contribution to genetic variation within humans is still being resolved.
Observations on the contributions of environmental restraints and innate stem cell ability to hematopoietic regeneration (1988)

A competitive repopulation assay utilizing chromosome markers was used to assay the reconstituting potential of hematopoietic populations. The test populations consisted of tibial murine marrow locally irradiated with doses ranging from 1.5 Gy to 8.5 Gy and of marrow generated from either murine splenic or marrow stem cells. The purpose of this assay was to assess the innate proliferative potential and microenvironmental influences on the ability to repopulate. Regardless of origin, spleen repopulating ability consistently agreed with spleen colony-forming unit (CFU-s) content. Doses of radiation from 5 Gy to 8.5 Gy diminished, by a factor of 2, the ability to repopulate marrow despite maintenance of CFU-s levels. Marrow generated from splenic stem cells had one-fifth the repopulating ability of marrow derived from marrow stem cells, even though CFU-s levels were equivalent. The results imply that the splenic environment can only maintain stem cells at the level of the CFU-s, even if the stem cells were originally of higher quality, and that their original potential cannot be regained in a marrow environment. Nevertheless, the marrow can maintain more primitive stem cells, but this reserve is drained to support CFU-s levels.
Synthesis of “Acetylene-Expanded” Tridentate Ligands (2002)

Synthetic routes to four new tridentate ligands with large cavities have been developed. Each ligand features two halides at the termini of the molecules that could be used for further elaboration of the system. Such compounds are ideal for encapsulating organoiodide guests using charge-transfer interactions.
Algorithmic Authority (2016)

This panel will explore algorithmic authority as it manifests and plays out across multiple domains. Algorithmic authority refers to the power of algorithms to manage human action and influence what information is accessible to users. Algorithms increasingly have the ability to affect everyday life, work practices, and economic systems through automated decision-making and interpretation of "big data". Cases of algorithmic authority include algorithmically curating news and social media feeds, evaluating job performance, matching dates, and hiring and firing employees. This panel will bring together researchers of quantified self, healthcare, digital labor, social media, and the sharing economy to deepen the emerging discourses on the ethics, politics, and economics of algorithmic authority in multiple domains.
14.5-MeV Neutron Activation Cross Section for Some of the Rare-Earth Nuclides and Their Relation to the Nuclear Shell Structure (1967)

The 14.5-MeV neutron cross sections for the production of $^{139m}\mathrm{Ce}$, $^{140}\mathrm{Pr}$, $^{141m}\mathrm{Nd}$, $^{143m}\mathrm{Sm}$, $^{143g}\mathrm{Sm}$, and $^{149}\mathrm{Nd}$ nuclides have been measured using thick-target samples. The ($n,2n$) cross sections for the target nuclides, some of which were calculated from previously reported isomeric yield ratios, have been plotted as functions of mass number and of the separation energies of the last neutron from the target nuclides. The results are discussed in the light of previously observed neutron shell effects in the systematics of ($n,2n$) cross sections. The importance of the cross-section measurements to the 14-MeV neutron activation analysis of these rare-earth elements is also pointed out.
Multidisciplinary Health Monitoring of a Steel Bridge Deck Structure (2013)

Fatigue cracks in orthotropic bridge decks are an important cause for the necessary renovation of existing bridges. Parallel utilization of various technologies based on different physical sensing principles can potentially maximize the efficiency of structural health monitoring (SHM) systems for these complex structures. A multidisciplinary SHM system composed of acoustic emission, strain measurements, and vibration measurement has been applied to a test steel bridge deck under a fatigue loading in a lab environment. Having the main focus on acoustic emission and strain measurement, the present paper provides an evaluation of the performance of the SHM system in terms of detection of the crack initiation, localization, and growth. During the destructive test, the strain measurement was employed as a local monitoring method, and acoustic emission was utilized as a local/global monitoring scheme. The monitoring performance was validated using visual inspection and time of flight diffraction (TOFD) measurements. Some of the main observations in this study are: (i) good agreement between the estimated crack size based on the strain measurement and TOFD measurement, (ii) the earlier detection of the crack activity by acoustic emission compared to the 10% deviation of the strain measured at a few millimeters away from the crack initiation location, and (iii) localization of multiple active cracks by acoustic emission.
Diagnosis of Phacoanaphylactic Endophthalmitis by Fine Needle Aspiration Biopsy (1999)

Diagnosis of phacoanaphylactic endophthalmitis (or lens induced uveitis), a rare autoimmune disease, is difficult due to variable clinical presentation. We sought to diagnose a case based on the cytopathology of the anterior chamber aspirate. This is a case report of spontaneous phacoanaphylactic endophthalmitis in a 79-year-old woman with no history of eye trauma or surgery. After clinical examination, diagnostic anterior chamber paracentesis was performed. Cytologic examination of the aspirate revealed polymorphonuclear leukocytes, histiocytes, and plasma cells surrounding amorphous lens material. A mature cataract was removed subsequently, and the eye has remained free of inflammation postoperatively. As the clinical diagnosis of phacoanaphylactic endophthalmitis is often difficult, cytopathology of an anterior chamber aspiration specimen may be useful in diagnosing this rare, treatable condition. As far as we know, this is the first case report of the diagnosis of phacoanaphylactic endophthalmitis solely by anterior chamber fine needle aspiration biopsy.
Respiratory Disease Due to Parainfluenza Virus in Adult Bone Marrow Transplant Recipients (1996)

We reviewed the frequency and clinical course of parainfluenza virus (PIV) infections in 1,173 adult bone marrow transplant (BMT) recipients cared for at The University of Texas M.D. Anderson Cancer Center (Houston). Between January 1991 and September 1994, PIV was isolated from the respiratory secretions of 61 (5.2%) of these patients. Thirty-four (56%) of the 61 patients had uncomplicated upper respiratory tract illnesses and survived. The remaining 27 patients (44%) developed pneumonia, and the associated mortality was 37% (10 of 27 patients). Twenty-three (85%) of the patients with pneumonia had had preceding upper respiratory illnesses. Of the 10 patients who died, nine died within 100 days after transplantation. Histopathologic examination of lung tissue from seven patients revealed intracytoplasmic viral inclusions in six, a finding consistent with invasive PIV pneumonia, and viral changes in the seventh patient. Seven of the 10 patients who died had other serious concurrent infections. Of 42 patients who developed PIV infection early after transplantation (i.e., < 100 days), the frequency of pneumonia was higher among the 18 allogeneic BMT recipients (61%) than among the 24 autologous BMT recipients (42%), and the associated mortality was also higher (55% vs. 30%, respectively). PIVs are an important cause of life-threatening pneumonia in adult BMT recipients, particularly patients who have recently undergone allogeneic bone marrow transplantation.
ChemInform Abstract: N‐Vinylpyrroles as Protected Pyrroles. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ray-Affine Functions: A General Dual Form to Describe Curves, Surfaces, and Volumes (1992)

In computer graphics modeling, two different forms are used to represent curves and surfaces: implicit and parametric. Functions that can be expressed both in implicit and parametric forms are called dual forms. To date, the only known dual forms are monoids and superquadrics. In this paper, we introduce a new dual form: ray-affine functions. Ray-affines include both monoids and superquadrics and provide a wide range of other modeling functions including exponentials and sinusoidals. Ray-affines are closed under operations that implement morphing, union, and interpolation. This feature of ray-affine functions lets the user construct a ray-affine function to model a shape as a smooth aproximation of a control shape given by set union or set intersection of shapes defined by simpler ray-affine functions.
On the effective mobility extraction by point-contact techniques on silicon-on-insulator substrates (2015)

In this work, we introduce the mobility vs. effective electric field representation for bare silicon-on-insulator substrates. The key factors determining the effective field in the silicon film are identified and modeled. This representation sheds light on the origins of the carrier mobility differences observed in passivated and non-passivated wafers. At low effective electric field, the roles of the Coulomb scattering, determined by the top-interface, and the impact of the silicon film thickness are clearly disclosed. Two and four point-contact characterization techniques are compared; caution is called when the two point Pseudo-MOSFET configuration is used without calibration of the current form factor, since it may lead to an underestimation of the mobility values. Nevertheless, when the effective field and current form factors are evaluated accurately, we report that the carrier mobility of the silicon film at high effective electric field, with passivated surface or not, obeys the Universal Mobility Curves.
Collaboration Scientifique Alger -Nantes-Marseille (2011)

La collaboration Scientifique entre\n l'Algérie et la France est illustrée ici par l'exemple des actions de recherche entre\n l'USTHB, l'Université de Nantes, l'Ecole Centrale de Nantes, l'Ecole des Mines de Nantes\n et l'Université Paul Cézanne d'Aix-Marseille.
Effect of Antibacterial Dental Adhesive on Multispecies Biofilms Formation (2015)

Antibacterial adhesives have favorable prospects to inhibit biofilms and secondary caries. The objectives of this study were to investigate the antibacterial effect of dental adhesives containing dimethylaminododecyl methacrylate (DMADDM) on different bacteria in controlled multispecies biofilms and its regulating effect on development of biofilm for the first time. Antibacterial material was synthesized, and Streptococcus mutans, Streptococcus gordonii, and Streptococcus sanguinis were chosen to form multispecies biofilms. Lactic acid assay and pH measurement were conducted to study the acid production of controlled multispecies biofilms. Anthrone method and exopolysaccharide (EPS):bacteria volume ratio measured by confocal laser scanning microscopy were performed to determine the EPS production of biofilms. The colony-forming unit counts, scanning electron microscope imaging, and dead:live volume ratio decided by confocal laser scanning microscopy were used to study the biomass change of controlled multispecies biofilms. The TaqMan real-time polymerase chain reaction and fluorescent in situ hybridization imaging were used to study the proportion change in multispecies biofilms of different groups. The results showed that DMADDM-containing adhesive groups slowed the pH drop and decreased the lactic acid production noticeably, especially lactic acid production in the 5% DMADDM group, which decreased 10- to 30-fold compared with control group (P < 0.05). EPS was reduced significantly in 5% DMADDM group (P < 0.05). The DMADDM groups reduced the colony-forming unit counts significantly (P < 0.05) and had higher dead:live volume ratio in biofilms compared with control group (P < 0.05). The proportion of S. mutans decreased steadily in DMADDM-containing groups and continually increased in control group, and the biofilm had a more healthy development tendency after the regulation of DMADDM. In conclusion, the adhesives containing DMADDM had remarkable antimicrobial properties to serve as "bioactive" adhesive materials and revealed its potential value for antibiofilm and anticaries clinical applications.
Acylphosphonic Derivatives - New Precursors for Low Coordination Phosphorus Species (1987)

Abstract Although dialkyl acylphosphonates (1) have been known for over four decades,1 their dealkylated derivatives, namely acylphosphonic acids (2) and alkyl hydrogen acylphosphonates (3), have only been isolated as salts. Characterization of compounds of type 2 and 3 have not been previously reported, neither have their chemical and physical properties been described. In this paper we wish to describe some new chemical properties of these types of compounds.