gebhart/patrepeval huggingface dataset:
PRISMS-4: Long-term efficacy of interferon-β-1a in relapsing MS (2001)

Clinical and MRI benefit continued for both doses up to 4 years, with evidence of dose response. Outcomes were consistently better for patients treated for 4 years than for patients in crossover groups. Efficacy decreased with neutralizing antibody formation.
A target‐site mutation is present in a glyphosate‐resistant <i>Lolium rigidum</i> population (2006)

Summary Annual ryegrass ( Lolium rigidum ) is the only weed species to have evolved resistance to the broad‐spectrum herbicide glyphosate in Australia. A population that had failed to be controlled by glyphosate was collected from a vineyard in the Adelaide Hills region of South Australia. Dose–response experiments on this population (SLR 77) showed that it was glyphosate resistant, with an LD 50 that was 1.9–3.4 times higher than that of a susceptible population (VLR 1). The movement of radiolabelled glyphosate within SLR 77 plants showed that this population did not have the differential glyphosate translocation mechanism of resistance common to several other Australian glyphosate‐resistant populations. Subsequent analysis of shikimic acid accumulation within the plant after glyphosate treatment showed that this population accumulated significantly less shikimic acid than a susceptible population, but more than a glyphosate‐resistant population with the translocation mechanism, indicating the possible involvement of another mechanism of resistance. Sequencing of a portion of the SLR 77 5‐enolpyruvylshikimate‐3‐phosphate synthase gene was carried out and a mutation causing an amino acid change at position 106 from proline to threonine was identified. This mutation is likely to be responsible for glyphosate resistance in this population, as mutations in this position have been found to be responsible for glyphosate resistance in goosegrass ( Eleusine indica ) from Malaysia. This paper represents the first report of target‐site glyphosate resistance in L. rigidum and provides evidence that this species has at least two mechanisms of glyphosate resistance present in Australia.
Advanced 5G substrates with integrated antennas (2017)

The objective of this research is to: 1) Survey commercially-available and development-level materials in three categories: Laminates, Glass and Ceramic (primarily LTCC) and benchmark them based on their electrical properties and processability for their suitability for 5G applications, and 2) Achieve transmission line loss of less than 0.05 dB/mm on these substrates, and 3) Perform a model-to-Hardware correlation study. The first task is being targeted by extensive paper study and collaboration with partners of PRC to extract properties of new materials. The second task is focused on achieving transmission line loss of less than 0.05 dB/mm with 2% linespace tolerance on selected substrate core and buildup layer combinations for 5G applications. The third task focuses on patch antennas at 5G frequencies as test structure to study the correlation of model and hardware and how the process variation affects the response of the test structure.\nFifth generation communication systems, abbreviated as 5G, allow much greater data rate capacity than 4G or LTE and more number of mobile broadband users per area. The target bands are 28 GHz (US) and 39 GHz (EU) along with 60 GHz. A new class of substrate technologies with embedded actives, advanced antennas, transmission lines with ultra-short interconnection lengths to actives are needed to realize such 5G systems. Glass presents a remarkable opportunity for 5G due to its low loss, superior dimensional stability, ability to form fine-pitch through-package-vias (TPVs), surface smoothness, stable dielectric constant and low loss tangent, and the advantage of easier panel-scale processing. Innovative 3D structures with fan-out or back-side assembly are developed to harness these benefits of glass, as illustrated. Advanced transmission line structures (Microstrip, CPW, CBCPW and SIW) and antenna structures (patch array, Yagi-Uda and horn) are explored with these 3D glass structures to achieve insertion loss of less than 0.05 dB/mm. A library of substrates is created after an extensive paper study which are suitable for 5G applications. Out of those substrates, three combinations of core and buildup materials are recommended and focused on for further research. A test vehicle for transmission line loss is fabricated on glass substrate with a thin double-sided buildup layer. The results are compared with models on two other substrates and a comparison is performed. For the model-to-hardware correlation study, rectangular patch antennas at four different resonant frequencies are fabricated on an ultra-thin glass substrate. The results are compared with the simulation and the discrepancy between the two is explained in terms of changes in electrical properties of glass at higher frequencies and small dimension variations during the process.
Silver Enhancement for Transmission Electron Microscopy Imaging of Antibody Fragment–Gold Nanoparticles Conjugates Immobilized on Ordered Mesoporous Silica (2015)

Ordered mesoporous silica (OMS) materials are receiving great attention as possible carriers for valuable but unstable drugs as, for example, therapeutic proteins. A key issue is to prove that the therapeutic protein is effectively able to penetrate the pores of OMS during the adsorption step. Here, we immobilized an antibody fragment [F(ab')GAMIgG] conjugated with ultrasmall gold nanoparticles (GNPs) onto amino-functionalized SBA-15 (SBA-NH2) mesoporous silica. The aim of this work is the visualization of the location of the conjugates adsorbed onto SBA-NH2 with transmission electron microscopy (TEM). Because of the ultrasmall size of GNPs (<1 nm), we use the silver enhancement procedure to amplify their size. In this procedure, ultrathin sections of conjugate-loaded SBA-NH2 particles are prepared by a ultramicrotome sectioning technique. The ultrasmall GNPs located on the top side of the 70-90 nm thick slices act as microcrystallization nucleation sites for the deposition of reduced metallic silver. Consequently, the ultrasmall GNPs increase their size. This allows for the direct imaging of the conjugates adsorbed. We clearly localize the F(ab')GAMIgG-GNPs conjugates either on the external surface of the particles or inside the mesopores of SBA-NH2 through TEM.
Stable Indicator Solutions for Complexometric Determination of Total Hardness in Water (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable Indicator Solutions for Complexometric Determination of Total Hardness in WaterE. M. DiskantCite this: Anal. Chem. 1952, 24, 11, 1856–1857Publication Date (Print):November 1, 1952Publication History Published online1 May 2002Published inissue 1 November 1952https://pubs.acs.org/doi/10.1021/ac60071a049https://doi.org/10.1021/ac60071a049research-articleACS PublicationsRequest reuse permissionsArticle Views327Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A kernel based structure matching for web services search (2007)

This paper describes a kernel based Web Services (abbrevi-ated as service) matching mechanism for service discoveryand integration. The matching mechanism tries to exploitthe latent semantics by the structure of services. Using textual similarity and n-spectrum kernel values as features of low-level and mid-level, we build up a model to estimate thefunctional similarity between services, whose parameters arelearned by a Ranking-SVM. The experiment results showedthat several metrics for the retrieval of services have beenimproved by our approach.
Immune System and Bone Regeneration (2015)

Kenneth A. Johnson bone, resulting in delayed or non-union is a vexing clinical problem in all species of animals. Recently, the focus of attention in orthopaedics has been on the treatment of fractures by bone grafts, mesenchymal stem cells, growth factors, biomaterials and improved mechanical environment, either alone or in some combination. These therapies have produced clearly demonstrable benefits in treating delayed and non-union. However there is still much to learn about the complex processes of fracture healing, and why it fails in some patients despite the management by ‘state of the art’ surgery employing, for example, minimally invasive osteosynthesis, locking implants, exogenous growth factor application, and 3D printed biomaterials and stem cells for the reconstruction of critical sized defects. Even so, in a proportion of fracture patients, endogenous factors predispose to impaired fracture healing. The pivotal role of immunity in fracture healing and bone regeneration was one such endogenous factor under discussion at the symposium. The immune system has direct involvement in guiding all stages of fracture healing starting with inflamImmune System and Bone Regeneration
Desensitizing Agent Efficacy during Whitening in an At‐Risk Population (2004)

This study suggests that the use of an active 3% potassium nitrate and 0.11% fluoride desensitizing agent for 30 minutes prior to whitening may decrease tooth sensitivity when compared with a placebo in a population at risk for tooth sensitivity.
Two-photon superbunching of thermal light via multiple two-photon path interference (2012)

We report on the two-photon superbunching effect of thermal light via constructive multiple two-photon path interference, showing the possibility of controlling the bunching property of thermal light in a linear optical system. By inserting $n$ pairs of mutually first-order incoherent optical channels as a cascade into the traditional Hanbury Brown and Twiss (HBT) interferometer, the two-photon bunching peak-to-background ratio of thermal light can be increased by up to $2\ifmmode\times\else\texttimes\fi{}1.{5}^{n}$, surpassing the theoretical upper limit of 2 for a traditional HBT interferometer. Experimentally, the ratio was measured to be $2.4\ifmmode\pm\else\textpm\fi{}0.1$ when one pair of optical channels was inserted. Such a scheme can be viewed as a prototype of a two-photon grating.
Introduction to fMRI: experimental design and data analysis (2008)

This provides an introduction to functional MRI, experimental design and data analysis procedures using statistical parametric mapping approach.
A influência da raiva e da empatia sobre a satisfação conjugal (2011)

Resumo: O estudo avaliou a influencia da raiva e da expressao de empatia no casamento sobre a satisfacao conjugal. Participaram da pesquisa 120 pessoas casadas, com idades de 25 a 76 anos. Para avaliacao foram utilizados tres instrumentos de autoinforme: Questionario de Empatia Conjugal; Escala de Satisfacao Conjugal e Inventario de Expressao de Raiva como Estado e Traco.Os resultados revelaram que houve correlacao positiva entre empatia conjugal e satisfacao conjugal (r = 0,48; p < 0,001), enquanto a raiva manteve correlacao negativa com a satisfacao conjugal (r = -0,30; p < 0,01). As analises de regressao multipla indicaram que a expressao de empatia aumenta e a raiva disfuncional diminui a satisfacao conjugal. Verificou-se tambem a influencia das variaveis idade, sexo, tempo de casamento e numero de filhos sobre a satisfacao no casamento. Conforme os principais resultados, conclui-se que a empatia e a raiva sao fatores que influenciam a satisfacao conjugal. Palavras-chave: raiva, empatia, satisfacao conjugal The influence of anger and empathy on the marital satisfaction
Conflicting Views on the Molecular Structure of the Cancer Antigen CA125/MUC16 (2010)

CA125 is a tumor antigen used to monitor the progression and regression of epithelial ovarian cancer. Despite the widespread use of CA125, the biochemical and molecular nature of this antigen is poorly understood. Analysis of the structure of CA125 is essential for determining the physiological role of this very significant tumor marker. Accumulated experimental evidence has shown that CA125 epitopes reside on a molecule of very complex architecture in terms of both protein backbone and oligosaccharide structures. It is not clear whether the heterogeneity of CA125 molecular characteristics are due to the variability of biological sources from which the molecule was isolated or to the different biophysical methods used for the characterization of all the oligosaccharides linked to CA125 or to the presence of glycoisoforms for this protein. This review attempts to summarize emerging data related to molecular characteristics of CA125 and to compare approaches undertaken to reach a better understanding of molecular features of this tumor marker.
Results of Eight Years with CGA-15281 as a Postbloom Thinner for Peaches (1983)

Abstract The ethylene-releasing agent CGA-15281 (2-chlorethyl-methylbis (phenylmethoxy) silane) effectively thinned fruit of several cultivars of peach [ Prunus persica (L.) Batsch.]. Thinning varied with cultivar, stage of development, concentration, and application technique. Negligible (<1%) leaf injury and drop occurred even at the higher (720 ppm) concentration over the 8-year period.
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses (2005)

The activation of signalling pathways by ligand engagement with transmembrane receptors is responsible for determining many aspects of cellular function and fate. While these outcomes are initially determined by the nature of the ligand and its receptor, it is also essential that intracellular enzymes, adaptor proteins and transcription factors are correctly assembled to convey the intended response. In recent years, it has become evident that proteins that regulate the amplitude and duration of these signalling responses are also critical in determining the function and fate of cells. Of these, the Cbl family of E3 ubiquitin ligases and adaptor proteins has emerged as key negative regulators of signals from many types of cell-surface receptors. The array of receptors and downstream signalling proteins that are regulated by Cbl proteins is diverse; however, in most cases, the receptors have a common link in that they either possess a tyrosine kinase domain or they form associations with cytoplasmic PTKs (protein tyrosine kinases). Thus Cbl proteins become involved in signalling responses at a time when PTKs are first activated and therefore provide an initial line of defence to ensure that signalling responses proceed at the desired intensity and duration.
Substituent effects on transition-state structures for dissociative and associative SN2 reactions (1991)

α-Deuterium secondary kinetic isotope effects (KIEs) have been investigated for the reactions of anilines with benzyl, methyl and ethyl benzenesulfonates involving deuteriated aniline nucleophiles and substrates. The secondary KIEs observed are normal, kH/kD > 1.0, only for the deuteriated benzyl system and are of an inverse type, kH/kD < 1.0, for the deuteriated methyl and ethyl systems as well as for all the deuteriated nucleophiles. These results suggest that the relief of steric strain by bond breaking of the leaving group prevails over the steric congestion incurred by bond formation of the nucleophile in the reactions of the benzyl compound (dissociative SN2 mechanism), in contrast to the reverse trend, i.e., the strain incurred by bond formation of the nucleophile is greater than the relief of steric congestion by bond breaking of the leaving group in the reactions of alkyl compounds (associative SN2 mechanism). The effects of substituents in the nucleophile (X) and leaving group (Z) on the secondary KIEs are in complete agreement with the transition-state variation predicted by the sign and magnitude of the cross-interaction constant, ρxz.
Structure and Tautomerism of the Esters of Several β-Substituted Pyruvic Acids<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and Tautomerism of the Esters of Several β-Substituted Pyruvic Acids1ALBERT M. STOCK, W. E. DONAHUE, and E. D. AMSTUTZCite this: J. Org. Chem. 1958, 23, 12, 1840–1848Publication Date (Print):December 1, 1958Publication History Published online1 May 2002Published inissue 1 December 1958https://pubs.acs.org/doi/10.1021/jo01106a006https://doi.org/10.1021/jo01106a006research-articleACS PublicationsRequest reuse permissionsArticle Views202Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
천안권역 내 주요 하천의 오염원 조사 및 수질관리 시스템의 구축 (1998)

To examine water quality in streams of Chonan watershed, surveys were conducted in August and November of 1998. Water quality data were collected from Environmental Center for Chonan city from Jan. 1995 to Dec. 1997. The existing data and newly establish
Laser-assisted optical rotational cell analyser (L.O.R.C.A.); II. Red blood cell deformability: Elongation index versus cell transit time (1994)

Red blood cell deformability was measured under normal and experimental conditions with the Laser-assisted Optical Rotational Cell Analyser (LORCA). Results were compared to simultaneously performed filtration measurements using the Cell Transit Anal
UNICORE 7 — Middleware services for distributed and federated computing (2016)

UNICORE is a mature middleware solution for building federated computing and data infrastructures (i.e. Grids), providing access to high-performance computing (HPC), clusters, file systems and other resources. This paper presents the state of the art in UNICORE, focusing on several major improvements that have been implemented for version 7 released in 2015. We have added RESTful APIs to UNICORE, allowing to easily create applications integrating the full range of UNICORE enabled data and compute resources. New features for data processing and analysis have been added. A new web portal allows simple web access. We have simplified the end-user experience by removing the requirement for X.509 certificates, establishing certificate-less authentication and trust delegation mechanisms. A new component, Unity, for identity management is presented, which enables a wide range of integration scenarios including SAML federations and OpenID connect.
Using Prior Knowledge to Improve Distributed Hill Climbing (2006)

The distributed probabilistic protocol (DPP) is a new, approximate algorithm for solving distributed constraint satisfaction problems (DCSPs) that exploits prior knowledge to improve the algorithm's convergence speed and efficiency. This protocol can most easily be thought of as a hybrid between the distributed breakout algorithm (DBA) and the distributed stochastic algorithm (DSA), because like DBA, agents exchange "improve" messages to control the search process, but like DSA, actually change their values based on a random probability. DPP improves upon these algorithms by having the agents exchange probability distributions that describe the likelihood of having particular "improve " values. These distributions can then be used by an agent to estimate the probability of having the best improve value among its neighbors or to compute the error caused by not informing other agents of changes to its improve value. This causes the protocol to use considerably fewer messages than both DBA and DSA, does not require a user to choose a randomness parameter like DSA, and allows DPP to more quickly converge onto good solutions. Overall, this protocol is empirically shown to be very competitive with both DSA and DBA.
View-invariance in action recognition (2005)

Automatically understanding human actions using motion trajectories derived from video sequences is a very challenging problem. Since an action takes place in 3-D, and is projected on 2-D image, depending on the viewpoint of the camera, the projected 2-D trajectory may vary. Therefore, the same action may have very different trajectories, and trajectories of different actions may look the same. This may create a problem in interpretation of trajectories at the higher level. However, if the representation of actions only captures characteristics, which are view-invariant, then the higher level interpretation can proceed without any ambiguity. In most of the current work on action recognition, the issue of view invariance has been ignored. Therefore, proposed methods do not succeed in more general situations. In this paper, we first present a view-invariant representation of action consisting of dynamic instants and intervals, which is computed using spatiotemporal curvature of a trajectory. Then this representation is used by our system to learn human actions without any training. The system is able to incrementally learn different actions starting with no model. It can discover instances of the same action performed by different people, and in different viewpoints.
Conformational Analysis of Sulfur-Containing 6-Deoxy-<scp>l</scp>-hexose Derivatives by Molecular Modeling and NMR Spectroscopy. A Theoretical Study and Experimental Evidence of Intramolecular Nonbonded Interactions between Sulfur and Oxygen (2003)

6-Deoxy-l-mannose diphenyldithioacetal (1) unexpectedly gave the rearranged products phenyl 3,4-di-O-acetyl-2-S-phenyl-1,2-dithio-6-deoxy-beta-l-glucopyranoside (9) and 3,4-di-O-acetyl-2,5-anhydro-6-deoxy-l-glucose diphenyldithioacetal (10) upon treatment with acetyl chloride, while 6-deoxy-l-mannose ethylenedithioacetal (3) yielded (4aR,6S,7S,8R,8aS)-7,8-diacetyloxy-6-methylhexahydro-4aH-[1,4]dithiino[2,3b]pyran (11), whose structure was further confirmed by X-ray diffraction, and 3,4-di-O-acetyl-2,5-anhydro-l-rhamnose ethylenedithioacetal (12). The geometry of the four rearranged products as well as that of 1-thio-6-deoxy-l-mannopyranosides 5 and 7 and their acetyl derivatives 6 and 8 was studied by density functional theory (B3LYP/6-31G) molecular models, in combination with a Karplus-type analysis of the NMR vicinal coupling constants, revealing that the six-membered ring of pyranosides 5-9 and 11 exists in a slightly distorted chair conformation (6-13% distortion) and that the conformational behavior of the 2,5-anhydro-6-deoxy-l-glucose dithioacetals 10 and 12 is strongly influenced by the presence of stabilizing intramolecular nonbonded sulfur-oxygen 1,4- and 1,5-interactions. Compounds 9-12 were formed by a molecular rearrangement via sulfonium ion intermediates followed by stereoselective intramolecular cyclizations as formulated by the quantum chemical calculations performed in the present study.