gebhart/patrepeval huggingface dataset:
Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy (2017)

Poor tumor penetration is a major challenge for the use of nanoparticles in anticancer therapy. Moreover, the inability to reach hypoxic tumor cells that are distant from blood vessels results in inadequate exposure to antitumor therapeutics and contributes to development of chemoresistance and increased metastasis. In the present study, we developed iRGD-modified nanoparticles for simultaneous tumor delivery of a photosensitizer indocyanine green (ICG) and hypoxia-activated prodrug tirapazamine (TPZ). The iRGD-modified nanoparticles loaded with ICG and TPZ showed significantly improved penetration in both 3D tumor spheroids in vitro and orthotopic breast tumors in vivo. ICG-mediated photodynamic therapy upon irradiation with a near-IR laser induced hypoxia, which activated antitumor activity of the codelivered TPZ for synergistic cell-killing effect. In vivo studies demonstrated that the nanoparticles could efficiently deliver the drug combination in 4T1 orthotopic tumors. Primary tumor growth and metastasis were effectively inhibited by the iRGD-modified combination nanoparticles with minimal side effects. The results also showed the anticancer benefits of codelivering ICG and TPZ in a single nanoparticle formulation in contrast to a mixture of nanoparticles containing individual drugs. The study demonstrates the benefits of combining tumor-penetrating nanoparticles with hypoxia-activated drug treatment and establishes a delivery platform for PDT and hypoxia-activated chemotherapy.
Eine Strukturbiologie für Membranproteine (2009)

Abstract Für viele Wissenschaftler sind Membranproteine ein faszinierendes Forschungsobjekt, für viele aber auch der schlimmste Alptraum, dem sie je begegnet sind. Letztere kämpfen mit intrinsischen Problemen: Expression, Reinigung, Stabilität, biochemische und biophysikalische Charakterisierung; die anderen begeistert die Funktion von Membranproteinen — Informationsaustausch über biologische Membranen, ohne die wahrscheinlich das Leben, wie wir es heute kennen, nicht existieren würde.
Helical vortices and Vortex Ring State in the wake of a rotor under normal and yawed inflow (2019)

International audience
A comparison of trucut biopsy with fine needle aspiration cytology in the diagnosis of breast cancer. (1999)

Carcinoma of the breast is common in Singapore and many patients may present with just a suspicious breast lump.To determine the accuracy of fine needle aspiration cytology (FNAC) and trucut biopsy in the diagnosis of suspicious breast lumps in an outpatient setting.A total of 39 women, from May 1995 to November 1995, who had a suspicious breast lump were subjected to concurrent FNAC and trucut biopsy.The accuracy of FNAC is 90% whereas trucut biopsy is 67%, the difference being statistically significant with a p < 0.02.FNAC is recommended for the diagnosis of suspicious breast lumps.
Patterns of reactivity of four novel monoclonal antibodies (B72.3, DF3, B1.1 and B6.2) with cells in human malignant and benign effusions. (1984)

The patterns of immunocytochemical reactivity produced in malignant and benign cells in effusions by staining with the monoclonal antibodies B72.3, DF3, B1.1 and B6.2 are reported. Using the mouse hybridoma methodology, these antibodies were raised against immunogens prepared from membrane-enriched extracts of metastatic carcinoma of the breast. Serial sections from the cell blocks of 20 benign effusions and 59 malignant effusions were incubated with the monoclonal antibodies using the avidin-biotin immunoperoxidase technique. The malignant neoplasms studied included specimens of 18 breast carcinomas, 12 ovarian carcinomas, 14 lung carcinomas, 7 leukemias/lymphomas and 8 miscellaneous malignant neoplasms. The monoclonal antibody B72.3 showed a positive staining reactivity with 36 of 39 adenocarcinomas (92%) versus staining in only 1 of 12 other neoplasms (8%). In contrast to the staining of adenocarcinomas, B72.3 stained no mesothelial cells in a total of 68 specimens tested. The monoclonal antibody DF3 showed a reaction pattern to neoplasms similar to that of B72.3 but also stained mesothelial cells in all of the specimens. The monoclonal antibodies B1.1 and B6.2 exhibited staining characteristics that have been associated with antibodies to carcinoembryonic antigen. The results of this study indicate that the monoclonal antibody B72.3 may function as a highly selective marker in recognizing a cancer cell versus a mesothelial cell and an adenocarcinoma cell versus other malignant tumor cells.
A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms (2013)

In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by a single amino acid insertion in the lever arm, a domain that adopts DNA sequence-specific conformations. We show that these isoforms differentially regulate gene expression levels through two mechanisms: differential DNA binding and altered communication between GR domains. Our studies suggest a versatile role for DNA in both modulating GR activity and also in directing the use of GR isoforms. We propose that the lever arm is a "fulcrum" for bidirectional allosteric signaling, conferring conformational changes in the DNA reading head that influence DNA sequence selectivity, as well as conferring changes in the dimerization domain that connect functionally with remote regulatory surfaces, thereby influencing which genes are regulated and the magnitude of their regulation.
Haematopoietic cell transplantation for haemophagocytic lymphohistiocytosis: experience at a single centre (2010)

<h3>Introduction</h3> Haemophagocytic lymphohistiocytosis (HLH) is a rare disorder of immune dysregulation that may be inherited or acquired. Causative genetic mutations are seen in around 50% of cases of primary HLH. Secondary HLH may be triggered by infections (most commonly viral), or by other conditions including malignancies and rheumatological disorders. Diagnostic criteria include prolonged high fever, hepatosplenomegaly, cytopenias and characteristic biochemical markers including elevated triglycerides, ferritin and low fibrinogen. Haematopoieitic cell transplantation (HCT) is the only curative treatment for primary HLH. The authors present their experience of HCT for HLH in a single centre over a 14 year period. <h3>Materials and Methods</h3> A retrospective case-note review was performed for all patients who fulfilled the diagnostic criteria for HLH, between 1994 and 2008. Data were collected for patients who had undergone HCT, or had died prior to HCT. <h3>Results</h3> 67 patients fulfilled criteria for HLH. Sixteen of 67 (24%) died prior to HCT. Fifty patients proceeded to HCT, of whom 35 (70%) remain alive and in remission. The mean time from diagnosis to HCT was 7 months. The median age at diagnosis was 0.35 years (range 0.1–9.8), 32/50 were male. Twelve received haploidentical grafts, 14 matched family donor, 11 matched unrelated donor, 11 mis-matched unrelated donor and 2 mis-matched family donor grafts. Twenty-three had myeloablative, 25 reduced intensity and 2 minimal intensity conditioning. After 1999 all patients having HCT for HLH underwent reduced intensity HCT. 15/50 (30%) patients died post-HCT. Causes of death were: pneumonitis (3), veno-occlusive disease (2), infections (3), cardiac failure (1), bleeding (1), seizure (1), EBV-related lymphoproliferative disease (1), drug toxicity (1), secondary AML and disease recurrence (1). Overall 9/21 (43%) patients are surviving from the cohort diagnosed prior to 2000, and 31/46 (67%) post 2000. <h3>Conclusion</h3> Outcome for HLH has improved with time reflecting earlier diagnosis and disease control, and the use of reduced intensity HCT with HLA matched donors. However, significant mortality from disease and from HCT related complications still remains and further progress is required.
Facile Diels−Alder Reactions with Pyridines Promoted by Tungsten (2005)

The isoquinuclidine (2-azabicyclo[2.2.2]octane) core is found in numerous molecules of biological and medicinal importance, including the widely investigated Iboga alkaloids and their related bisindole Cantharanthus alkaloids (Sundberg, R. J.; Smith, S. Q. Alkaloids (San Diego, CA, United States) 2002, 59, 281-386). A diverse range of synthetic methods for the stereoselective construction of this architecture is required for the efficient development of related pharmaceuticals. Here, we report a fundamentally new methodology that constructs the isoquinuclidine core directly from pyridines, using a pi-basic tungsten complex to disrupt the aromatic stabilization of these otherwise inert heterocycles. By this approach, common pyridines are found to undergo stereoselective Diels-Alder reactions with electron-deficient alkenes under mild reaction conditions, thus providing access to a broad range of functionalized isoquinuclidines. Further, by using the common terpene alpha-pinene, a single enantiomer of the tungsten fragment can be isolated and used to provide access to enantio-enriched isoquinuclidines from pyridines.
Okuläre Pulsamplitude bei okulärer Hypertension und verschiedenen Glaukomformen (1997)

The present study was designed to investigate choroidal perfusion in primary open-angle glaucoma patients with statistically elevated (HPG) and statistically normal (NPG) intraocular pressure (IOP) and in ocular hypertensive volunteers (OHT) before and after application of topical antiglaucomatous drugs. When compared to age-matched healthy controls, ocular pulse amplitude (OPA) and IOP were significantly increased in OHT and unchanged in HPG; in NPG, the IOP was unchanged, and the OPA was significantly reduced. The topical antiglaucomatous drugs used in this study reduced IOP, but did not increase OPA. When compared to HPG and NPG, OHT subjects showed increased choroidal perfusion which may help to prevent glaucomatous optic nerve damage.
Investigation of carrier transport in a system of undoped quantum wells under pulsed excitation (1997)

A phenomenological theory describing nonstationary carrier transport processes in a system of undoped quantum wells with short carrier generation pulses is developed. An experimental method for finding the characteristic carrier trapping and carrier emission times from the wells is proposed on the basis of the theoretical expressions. The first experimental results making it possible in principle to determine these parameters are reported.
Ferromagnetic GaN:MnAlSi nanowires (2006)

The fabrication of crystalline Al-codoped GaN:Mn nanowires with a Mn doping rate of approximately 7at.% is reported. The magnetism measurements show that the Curie temperature is above 350K. X-ray and electron diffractions do not show the presence of any secondary magnetic phases. The electrical transport measurement indicates that the nanowires are of n-type semiconductor.
Compact design of UWB CPW-fed-patch antenna using the superformula (2016)

This paper presents a new design of compact coplanar waveguide (CPW)-fed patch antenna for UWB operation. The shape of the patch is obtained by choosing the six different parameters of the closed form superformula, resulting in a circular patch with sawtooth-like circumference. Simulation results demonstrate that the derived antenna operates in the FCC band (3.1-10.6 GHz) for UWB operation. In comparison to the conventional CPW-fed-circular patch antenna whose optimal diameter is 25 mm, the circular patch of the proposed design has a diameter of 18.2 mm. Moreover, the proposed antenna has an improved group delay, with similar radiation and gain characteristics. Simulation results using HFSS are provided to verify the design and performance.
Boosting tag-based search in social media sites (2015)

The availability and pervasive use of smart mobile devices makes it easy to upload videos and photos to the social websites and label them with any arbitrary tags from anywhere and anytime. This paper exploits the social tagging information and reveals the latent hidden tags which might be relevant to a social media item to improve the tag-based search process. The proposed approach predicts links in undirected weighted tripartite graph. From a graph-based proximity perspective, our approach finds the appropriate personalized item in response to the user's query as well as uncovers the hidden tags potentially relevant to a given item. We evaluate our method on real-world social tagging system collected from MovieLens. The experimental evaluation shows that enriching the low annotated items with hidden tags improves the tag-based search performance.
Coastdown Time as a Mechanical Condition Indicator for Vertical Axis Motors with Grease-Lubricated Ball Bearings (1979)

A technique is presented to assess the mechanical condition of vertical axis electric motors equipped with grease-lubricated ball bearings by comparing observed and predicted rotor coastdown times. A theoretical expression for calculating the coastdown time required, as input, a relationship between rotor torque and rotational speed. Torque values derived from existing theory in the literature proved unsatisfactory. Experiments were conducted on four electric motors with varying bearing size and preload, blade configuration and grease lubricant properties to refine the input criteria. Substitution of these empirically derived torque values into the expression then gave acceptable results. Deviation of actual coastdown times from those predicted indicates a probable mechanical problem and need for investigation.
Distributed Resources Management in Wireless LANs (2006)

This paper introduces a new radio resource management technique based on distributed dynamic channel assignment, and sharing load among Access Points (AP). Deploying wireless LANs (WLAN) on a large scale is mainly affected by reliability, availability and performance. These parameters will be a concern for most managers who want to deploy WLANs. In order to address these concerns, a new radio resource management technique can be used in a new generation of wireless LAN equipment. This technique would include distributed dynamic channel assignment, and load sharing among Access Points (AP), which improves the network availability and reliability compared to centralized management techniques. In addition, it will help to increase network capacities and improve performance, especially in large-scale WLANs. Analysis results using normal and binomial distribution have been included which indicate an improvement of performance resulting from network balancing when implementing distributed resources management at WLANs.
Micro-composites formés d'une couche continue de zéolithe recouvrant un coeur de zéolithe – Etude des processus de formation (2005)

The present thesis deals with the preparation and the mechanism of formation of core-shell zeolite micro-composites comprising a single crystal core and a polycrystalline shell. Several framework types (BEA, FAU, LTA, MFI, MOR, SOD) covering a broad range of chemical compositions were combined in the course of this study in order to determine the factors controlling the formation of the composites. Two approaches, a direct synthesis and a secondary growth after seeding of the core surface, were employed. The reactivity of the core surface and structural similarities of the zeolites building the composite were found to be of paramount importance for the direct unseeded synthesis. The factors controlling the composite formation via secondary growth were found to be: (i) the composition of the two counterparts; (ii) the stability of the core crystals in the synthesis media; and (iii) the rapid crystal growth kinetics of the shell. The synthesized core-shell composites are expected to show improved performance in the existing petrochemical processes and to open routes for new applications for zeolite materials.
Ethics and research governance: the views of researchers, health-care professionals and other stakeholders (2008)

The objective of this study is to describe researchers', health-care providers' and other stakeholders' views of ethical review and research governance procedures. The study design involved qualitative semi-structured interviews. Participants included 60 individuals who either undertook research in the subspecialty of cancer genetics ( n = 40) or were involved in biomedical research in other capacities ( n = 20), e.g. research governance and oversight, patient support groups or research funding. While all interviewees observed that oversight is necessary to protect research participants, ethical review and research governance (ERG) arrangements were described negatively throughout these interviews. Interviewees identified a number of problems with ERG, including: over-bureaucratization, over-standardization of information requirements for different types of research, a lack of standardization in the types of information required by different committees for the same research and a lack of consistency in different committees' responses. A number of solutions were proposed including streamlining application procedures and harmonizing committees' responses and information requirements. Recent reports suggest that ethical review procedures and research governance arrangements threaten the possibility of undertaking clinical research in the UK, hence the introduction of the Integrated Research Application System (IRAS) is long overdue. However, while IRAS may solve some of the problems identified by interviewees, it remains to be seen to what extent it will impact upon the very negative perceptions of ethics and research governance procedures reported here.
What data determine whether a plant taxon is distinct enough to merit legal protection? A case study of <i>Sedum integrifolium</i> (Crassulaceae) (2001)

Measures of molecular and morphological genetic variation are often used to set conservation priorities and design management strategies for plant taxa. Evaluated together they can give insights into a taxon's evolutionary status that neither data type alone can achieve. We investigated the distinctness and variability of Sedum integrifolium ssp. leedyi, a federally and state-listed taxon, from its conspecific relatives using 33 random amplified polymorphic DNA (RAPD) markers (253 plants) and 37 morphological characters from 1308 common-garden-grown plants. We included S. integrifolium ssp. leedyi (four populations), its conspecific relatives (11 populations), and S. rosea and S. rhodanthum populations in our study. The morphological and molecular data correspond in showing that S. integrifolium ssp. leedyi populations are highly distinct. However, the data sets differ in their estimates of the relatedness of some S. integrifolium ssp. leedyi populations and in the percentage variation detected due to differences among them (25 and 9-13% for the molecular and morphological data, respectively) suggesting little gene flow among populations and some differentiation, possibly from selective pressures. Given our data, we recommend that S. integrifolium ssp. leedyi merits protection under the U.S. Endangered Species Act and that its populations be managed as distinct units.
Glucose and Insulin Metabolism in Uremia (1992)

Review Articles| December 11 2008 Glucose and Insulin Metabolism in Uremia Subject Area: Nephrology Robert H.K. Mak; Robert H.K. Mak aDivision of Nephrology, Children's Hospital of Los Angeles University of Southern California, School of Medicine, Los Angeles, Calif; Search for other works by this author on: This Site PubMed Google Scholar Ralph A. De Fronzo Ralph A. De Fronzo bDivision of Diabetes, University of Texas Health Science Center at San Antonio, Tex., USA Search for other works by this author on: This Site PubMed Google Scholar Nephron (1992) 61 (4): 377–382. https://doi.org/10.1159/000186953 Article history Accepted: January 28 1992 Published Online: December 11 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Robert H.K. Mak, Ralph A. De Fronzo; Glucose and Insulin Metabolism in Uremia. Nephron 1 April 1992; 61 (4): 377–382. https://doi.org/10.1159/000186953 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsNephron Search Advanced Search This content is only available via PDF. 1992Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
A model of the radio continuum filaments in the galactic center (1985)

High-resolution radio continuum studies of the galactic center have revealed several spiral-like structures within the central 2 pc. The authors show that one of these structures can be modeled as the infall and tidal breakup of a small molecular cloud under the influence of the gravitational field of the center of the galaxy and a dissipative medium. The derived model parameters and model geometry imply the ejection of material near the escape velocity and the existence of a diffuse interstellar medium with a temperature of order 10<SUP>6</SUP>K.
Semantic analysis of SNOMED CT for a post-coordinated database of histopathology findings (2014)

UNMC Institutional Review Board ID# 342-11-EP.
Permeation enhancers compatible with transdermal drug delivery systems. Part I: selection and formulation considerations. (1992)

Part I of this article reviews the classification, chemistry, properties, selection, and use of skin permeation enhancers in transdermal drug delivery systems and dermal patches. The authors discuss ideal properties of enhancers and describe various enhancers' actions on the skin. Part II will describe interactions between permeation enhancers and other transdermal delivery system components, such as backing materials, pressure-sensitive adhesives, membranes, and release liners. Adhesive properties critical to the optimization of a transdermal formulation will be discussed.