gebhart/patrepeval huggingface dataset:
HLA-C disparity between patients and unrelated donors matched for HLA-A, -B, and -DRB1 alleles: Impact of serological vs. DNA typing for HLA-A and -B loci (1999)

High incidences of graft failure, graft-vs.-host disease (GVHD), and serious infections following unrelated donor (URD) marrow transplantation, despite apparent human leukocyte antigen (HLA) identity, may reflect the presence of molecular disparities, including those for HLA-C alleles between the patient and the URD. The level of these disparities could be significant, because as many as 42 alleles are currently known for HLA-C locus. We studied 84 patients and 251 potential URDs to evaluate 1) the extent of HLA-C disparity between the patient and the URD identified by serology for HLA-A and -B and by DNA typing for -DRB1 and 2) the level of HLA-C disparity between patients and URDs matched by high-resolution DNA typing for HLA-A, -B, and -DRB1. The DNA typing was performed at the Memorial Sloan Kettering Cancer Center, and the serotyping was provided by the registries. Of 251 URDs matched by HLA-A and -B serology and -DRB1 (sA_sB_dnaDRB1 ); 94, 75, and 82 were 6/6, 5/6, and 4/6 matches, respectively. Of 94 sA_sB_dnaDRB1 6/6 URDs, 51 (54.3%) were matched for both HLA-C alleles. In contrast, 31 (41.3%) 5/6 (p=0.12) and 15 (18.3%) 4/6 (p < 0.01) sA_sB_dnaDRB1 URDs were matched for both HLA-C alleles. Following DNA typing for HLA-A and -B, 52 (55.3%) of 94 6/6, 30 (40%) of 75 5/6, and 25 (30.5%) of 82 4/6 sA_sB_dnaDRB1 URDs remained 6/6, 5/6, and 4/6 matches at the DNA level (dnaA_B_DRB1). HLA-C disparities continued to exist in the dnaA_B_DRB1 URD group. Of 54 dnaA_B_DRB1 6/6 URDs, 41 (75.9%) were matched for both HLA-C alleles. Only 45.3% of the 5/6 (p=0.01) and 22.2% of the 4/6 (p < 0.01) dnaA_B_DRB1 URDs were matched for both HLA-C alleles. In the 6/6 category, the frequency of HLA-C matching improved (75.9 vs. 54.3%; p=0.01) following DNA matching for HLA-A and -B. In comparison to mismatching for HLA-B locus, mismatching for either HLA-DRB1 or -A resulted in a lower odds ratio for HLA-C disparity. The presence of a common haplotype in the sA_sB_dnaDRBl (p=0.06) URD category improved the level of HLA-C matching. We identified alleles that are associated with high (B*1501, B*4402, B*5101, DRB1*0101, A*0201, A*1101, A*2301, and A*3201) or low (B*0702, B*0801, B*1302, B*3502, DRB1*0301, DRB1*1104, A*0101, A*3001, and A*6801) probability of HLA-C disparity. Overall, sA_sB_dnaDRB1 as well as dnaA_B_DRB1 matched URDs for non-Caucasian patients were more likely to have HLA-C disparity in comparison to the matched URDs of Caucasian patients. However, a high incidence of HLA-C disparities was identified even in the URDs for Caucasian patients. Whether the disparities demonstrated by this study contribute to the higher immunological complications noted following URD bone marrow transplantation is unclear. Outcome analysis and studies aimed at understanding the functional role of HLA-C may provide an answer.
Tubular and Interstitial Nephrocalcinosis (2007)

There are 2 distinct forms of nephrocalcinosis, including tubular nephrocalcinosis, which seems to be reserved for specific conditions such as chronic pyelonephritis, and interstitial nephrocalcinosis. The incidence of tubular calcium oxalate nephrocalcinosis could be underestimated due to the loss of crystals during tissue processing for routine histology. The crystal binding molecule hyaluronan may have a role in the 2 forms of nephrocalcinosis.
Selected Bivariate Anthropometric Distributions Describing a Sample of Naval Aviators - 1964, (1971)

Abstract : Previous anthropometric surveys presented means, standard deviations, ranges, and percentiles as descriptors of the anthropometric features of aviator populations. These reports were limited to a consideration of each variable independently. However, designers also need knowledge of the interaction between variables in order to determine what proportion of the potential operator population their design decisions will eliminate. This report extends data previously collected from 1549 naval aviation personnel by presenting bivariate tables that illustrate the relationship between selected variables. Twenty-one tables were prepared which contained selected interactions between the following variables: bideltoid diameter; buttock-knee length; eye height, sitting; functional reach; head height; knee height, sitting; sitting height; shoulder height, sitting; standing height; and thigh circumference. Means, standard deviations, ranges, regression equations, standard error of estimate, and percentile levels were also presented for each variable. (Author)
Multiphase digitally controlled oscillator for future 5G phased arrays in 90 nm CMOS (2016)

This paper reports a low noise Digitally Controlled Oscillator (DCO) with multiphase outputs, suitable for next generation phased arrays. The DCO core is implemented using an 8 stage Rotary Traveling Wave Oscillator (RTWO) topology. Simple design equations are presented and insight is given in the layout implementation. Designed in a 90 nm CMOS process, the prototype is tunable from 31.4 to 37 GHz (i.e. 16% tuning range). Drawing 45 mW from a 1.2V supply, the simulated phase noise is -127.3 dBc/Hz at 10 MHz offset from a 34 GHz carrier, resulting in a phase-noise FoM of -181.4 dBc/Hz. Digitally tuned slow wave transmission lines are used to achieve a fine tuning resolution of 1.8 MHz, resulting in a state-of-the-art tuning FoM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DT</sub> of -187 dBc/Hz.
Efficient Cellular Entry of (r-x-r)-Type Carbamate–Plasmid DNA Complexes and Its Implication for Noninvasive Topical DNA Delivery to Skin (2016)

Arginine-rich cell penetrating peptides are powerful tools for in vitro as well as in vivo delivery of a wide plethora of biomolecules. However, presence of consecutive arginine residues leads to enhanced amenability for proteolytic degradation as well as steric hindrances for membrane interactions which compromise its bioavailability. In order to overcome these limitations we previously reported a safe and stable octaarginine based oligomer, i.e., (r-x-r)4-carbamate, where the backbone amide linkages were replaced by carbamate linkages and 6-aminohexanoic acid based spacer moieties were incorporated for better flexibility, hydrophobicity, optimal spacing of guanidinium groups, and protection against proteolytic cleavage; resulting in improved transfection efficiency over its amide counterpart. In the present work we have investigated the mechanism behind this enhanced transfection efficiency and, based on our observations, demonstrate how the synergistic effect of rationalized oligomer designing, complex characteristics, and cell type contributes to overall effective intracellular delivery. Our results indicate that the (r-x-r)4-carbamate-plasmid DNA complexes primarily utilize lipid raft dependent pathway of cellular entry more than other pathways, and this possibly facilitates their increased entry in the lipid raft rich milieu of skin cells. We also emphasize the utility of oligomer (r-x-r)4-carbamate as an efficient carrier for topical delivery of nucleic acids in skin tissue. This carrier can be utilized for safe, efficient, and noninvasive delivery of therapeutically relevant macromolecular hydrophilic cargo like nucleic acids to skin.
The application of cell penetrating peptides for the delivery of neuroprotective peptides/proteins in experimental cerebral ischaemia studies (2009)

The restricted ability of most proteins and peptides to cross the blood-brain barrier and/or plasma membrane limits their use as therapeutics following cerebral ischaemia. However, the discovery of cell-penetrating peptides has provided a means by which such molecules can be transported across the blood-brain barrier and plasma membrane. Many proteins/peptides have already been shown to have neuroprotective properties, and, due to their ability to block protein-protein interactions, provide a potentially rich source of new therapeutic compounds to prevent cell death following cerebral ischaemia. In this review, we give an overview of cell-penetrating peptides and their use experimentally to deliver neuroprotectant proteins/peptides into the brain following cerebral ischaemia.
NEUTRALIZING ANTIBODIES AGAINST MOUSE-ADAPTED LANSING STRAIN OF POLIOMYELITIS VIRUS IN THE SERA OF ACUTE AND CONVALESCENT CASES AND NORMAL INDIVIDUALS (1950)

The present communication deals with a survey of neutralizing antibodies to mouse-adapted Lansing strain of poliomyelitis virus in the sera of acute, convalescent, and normal individuals during a 1946 epidemic. Two-phase sera were obtained from residents of Ontario and British Columbia and convalescent and normal sera from Quebec. In the sera of 17 out of 35 Ontario patients neutralizing antibodies were demonstrable during the acute stage. In four of these seropositive individuals, there was an increase in the neutralizing titer during convalescence and in three patients there was a notable drop in the titer. The remaining 18 patients were found to be seronegative during both the acute and convalescent stages. Sera from six out of nine British Columbia patients, likewise contained neutralizing antibodies to the Lansing strain of virus during the acute stage. In four of these the titer remained unchanged during convalescence, in one the titer decreased, and another patient became seronegative. Of the remaining three, two continued to be seronegative and one became seropositive during convalescence. Positive neutralization reactions were obtained with 17 out of 44 convalescent sera from Ontario and 62 out of 146 convalescent sera from Quebec Sera from 51 children without history of poliomyelitis and 100 adult sera taken at random from specimens submitted for Wassermann tests were obtained from Quebec. Of the children's sera 43%, and of the adults’, 48%, contained neutralizing antibodies. The results obtained closely agree with those reported by American workers.
Temporal sensitivities related to color theory (1984)

Sensitivities of color-normal observers to temporal variations in stimulus luminance and chromaticity were measured for sine-wave stimuli between 1.5 and 20 Hz. Clear differences were found in observers' sensitivities to isochromatic luminance variations and to isoluminous chromaticity variations for wavelength pairs selected to test temporal discriminability along the red-green and yellow-blue dimensions, respectively. Despite interobserver differences in individual red-green functions, a given observer's sensitivity could be described by a single curve shape specific to that observer. Overall sensitivity for yellow-blue was less than that for red-green for all observers. Differences in curve shape between red-green and yellow-blue functions are found for individual observers, but group averages reveal that the differences are not systematic. Red-green temporal sensitivity is largely unaffected by adapting backgrounds in red-green equilibrium but is attenuated at low frequencies by nonequilibrium backgrounds of the same luminance. Isochromatic luminance sensitivity is largely independent of our adapting backgrounds, but heterochromatic luminance modulation functions undergo expected changes in form.
Inactivation of simian immunodeficiency virus by hydrostatic pressure. (1995)

The inactivation of the simian immunodeficiency viruses SIVmac251 and SIVagm by pressures of 150 and 250 MPa was determined. The extent of inactivation depended on the time that the virus was subjected to compression as well as the level of the pressure and at 150 Mpa reached 5 log10 dilution units after approximately 10 hr. The inactivations, which were uniformly carried out at room temperature, were independent of the concentration of the virus. Possible applications of pressure inactivation for molecular biological and clinical use are discussed.
A hybrid integrity solution for precision landing and guidance (2004)

A design was developed for a hybrid integrity solution for precision approach and landing in a GPS jamming environment. The integrity solution described in this paper leverages the capabilities of next generation digital spatial processing and ultra-tightly-coupled (UTC) GPS/inertial integrated military user equipment (UE). A design is also included for a spatial environment integrity monitor, for a GPS/inertial receiver autonomous integrity monitor solution (GI-RAIM) that allows detection of small error drift rates before the inertial solution can be corrupted and an integrity monitoring function embedded within the kinematic carrier phase tracking (KCPT) algorithms which provides a level of confidence on the final KCPT positioning data output. Simulation and test results showing the expected performance of this multi-level integrity monitoring approach are presented. A design for an aircraft GPS/inertial digital spatial processing receiver, the HAGR-A, is also included which will be used as a test bed for implementation and testing of these integrity monitoring techniques.
The Preparation and Characterization of Activated Carbon from Coffee Residue (2004)

Coffee residues from instant coffee plants were used to produce mesoporous activated carbon. A series of carbonization and activation conditions were examined to elucidate the effect of each condition. The specific surface area, mesopore and total pore volumes were evaluated by nitrogen adsorption at 77 K, and the surface chemistry was characterized by FTIR. The activated carbon derived in the conditions of a ZnCl2/coffee weight ratio of 3, an activation temperature of 600°C and a CO2 activation time of 4 h (R30T600H4) yielded a surface area of 900 m2/g, a total pore volume of 1.01 cm3/g with a mesopore content of 92%. The FTIR results demonstrated that the C–H group was the main functional group on the surface of coffee-derived activated carbon. The adsorptive capacities of R30T600H4 compared with a commercial activated carbon CAL for phenol, methylene blue and erythrosine red. We found that for small molecules such as phenol and methylene blue the adsorption capacity of R30T600H4 was lower than that of CAL, whereas, for larger molecules such as erythrosine red R30T600H4 was higher. The mesoporous structure and the surface chemistry of coffee-derived activated carbon associated in the adsorption were discussed.
Compressible flow across narrow passages: Comparison of theory and experiment for face seals (1978)

Computer calculation for determining compressible flow across radial face seals were compared with measured results obtained in a seal simulator rig at pressure ratios to 0.9 (ambient pressure/sealed pressure). In general, the measured and calculated leakages across the seal dam agreed within 3 percent. The resultant loss coefficient, dependent upon the pressure ratio, ranged from 0.47 to 0.68. The calculated pressures were within 2.5 N/cu um of the measured values.
Prognosis of Alkali Aggregate Reaction with SEM (2011)

Alkali aggregate reaction (AAR) is known leading to great damage in concrete, both in compressive strength and in durability. In this study, a backscattered scanning electron microscopy with energy dispersive spectroscopy is adopted to diagnose AAR reaction. The results show that the type of AAR reaction and reaction products can be easily identified and the method is precise and fast.
Infection with the Intracellular Protozoan Parasite <i>Theileria parva</i> Induces Constitutively High Levels of NF-κB in Bovine T Lymphocytes (1989)

The intracellular protozoan parasite Theileria parva causes a lymphoproliferative disease of T cells in cattle and uncontrolled lymphocyte proliferation in culture. We have identified and characterized in infected cells the transcriptional activator, NF-kappa B, whose recognition motifs have been identified in several gene enhancers important for lymphocyte-specific gene expression. NF-kappa B is normally constitutively activated in nuclear extracts derived from B cells and can be induced in T cells and nonlymphoid cells by phorbol esters. Theileria-infected lymphocytes contained constitutively high levels of activated NF-kappa B in nuclear fractions and inactive NF-kappa B in cytoplasmic fractions. The inactive cytoplasmic precursor could be activated by treatment of extracts with deoxycholate, which was shown previously to dissociate NF-kappa B from an inhibitor, I kappa B. Treatment of lymphocyte extracts with 3 mM GTP stimulated NF-kappa B binding to its recognition motif in vitro, thereby distinguishing it from a related nuclear factor, H2-TF1. Selective killing of the parasite, which left the host cells intact, resulted in a rapid loss of NF-kappa B from the nuclear fractions and a slower loss from the cytoplasmic fractions. In parasitized cells, NF-kappa B could not be further stimulated by treatment with 12-O-tetradecanoylphorbol-13-acetate whereas in cells treated to remove the parasite, this compound stimulated elevated levels of NF-kappa B. We propose that high levels of activated NF-kappa B are maintained by the presence of the parasite in infected T cells. Similarly, we propose that the high levels of inactive cytoplasmic precursor are a result of increased synthesis due to the presence of the parasite.
Variation in the Microbiota of Ixodes Ticks with Regard to Geography, Species, and Sex (2015)

Ixodes scapularis is the principal vector of Lyme disease on the East Coast and in the upper Midwest regions of the United States, yet the tick is also present in the Southeast, where Lyme disease is absent or rare. A closely related species, I. affinis, also carries the pathogen in the South but does not seem to transmit it to humans. In order to better understand the geographic diversity of the tick, we analyzed the microbiota of 104 adult I. scapularis and 13 adult I. affinis ticks captured in 19 locations in South Carolina, North Carolina, Virginia, Connecticut, and New York. Initially, ticks from 4 sites were analyzed by 454 pyrosequencing. Subsequently, ticks from these sites plus 15 others were analyzed by sequencing with an Illumina MiSeq machine. By both analyses, the microbiomes of female ticks were significantly less diverse than those of male ticks. The dissimilarity between tick microbiomes increased with distance between sites, and the state in which a tick was collected could be inferred from its microbiota. The genus Rickettsia was prominent in all locations. Borrelia was also present in most locations and was present at especially high levels in one site in western Virginia. In contrast, members of the family Enterobacteriaceae were very common in North Carolina I. scapularis ticks but uncommon in I. scapularis ticks from other sites and in North Carolina I. affinis ticks. These data suggest substantial variations in the Ixodes microbiota in association with geography, species, and sex.
Monteris AXiiiS Stereotactic Miniframe for Intracranial Biopsy (2015)

The AXiiiS stereotactic miniframe is a feasible, safe, and disposable platform for multitrajectory intracranial biopsies. Compared with existing platforms, this novel device provides a more stable base and wider limits of trajectory angles with comparable accuracy and precision.
Development of Deformable Computational Model for Korean Adult Male Based on Polygon and NURBS Surfaces (2009)

In the present study, a high-quality voxel model of a Korean adult male was converted to a surface model based on polygon and nonuniform rational B-spline surfaces. The polygon model of the body surface was then modified in the back and buttock regions for some correction and finally converted back to a voxel model for Monte Carlo dose calculations. The dose calculation results showed that the modification of the back and buttock significantly changed the calculated dose values of the lungs and breasts for the postero-anterior irradiation geometry; the maximum difference, found for the lungs, was as large as 40% for the photon energy of 30 keV, even though the difference decreases with the photon energy.
IrrE, a Global Regulator of Extreme Radiation Resistance in Deinococcus radiodurans, Enhances Salt Tolerance in Escherichia coli and Brassica napus (2009)

Expression of IrrE, a global regulator for extreme radiation resistance in D. radiodurans, confers significantly enhanced salt tolerance in both E. coli and B. napus. We thus propose that the irrE gene might be used as a potentially promising transgene to improve abiotic stress tolerances in crop plants.
Computer as a group teaching aid for persons who are blind: A Technical Note (1992)

A concept has been formulated whereby a teacher in a classroom for students who are blind can communicate line diagrams and text directly to the students. This approach is based upon a single computer placed on the teacher's desk, with monitors on the students' desks. Access to the information displayed on the monitors is obtained by means of an optoelectronic sensor and vibrotactile output. Two versions of the sensor have been made--one for sensing line diagrams, and the other for Braille text. A simple, low-cost arrangement has also been designed by which students who are blind can prepare a hard copy of the diagrams from the monitor display. The special feature of the system is that it allows the teacher to convey information directly to the students, that is, diagrams and text that have been entered into the computer while the students are in the classroom. Information previously stored on floppy disks may also be communicated in this way. This methodology will overcome the current limitation where the teacher is able to hand out only embossed diagrams and text that have been previously prepared. Learning to use the new system can be accomplished in a short time, with the added advantage that the system is relatively inexpensive.
Practical Kerogen Typing for Petroleum Exploration: ABSTRACT (1989)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Applications of Fast‐Setting Hydroxyapatite Cement: Cranioplasty (2000)

A variety of autogenous and synthetic materials have been used to repair cranial defects resulting from traumatic and iatrogenic causes. In theory, the ideal material should be readily available and safe. It should adequately protect the underlying central nervous system, resist cerebrospinal fluid fistula formation, and be easily contoured. One promising synthetic biomaterial that has been used for cranioplasty is hydroxyapatite cement. This biomaterial has successfully restored cranial contour in most patients in whom it has been used; however, difficulties have arisen because of the material's prolonged water solubility. When exposed to cerebrospinal fluid or blood, inadequate setting of the cement occurs, resulting in loss of its structural integrity. This problem can be alleviated with the use of fast-setting hydroxyapatite cement, which hardens 6 to 12 times faster than the traditional cement. We present, to the best of our knowledge, the first series of the use of this material in 21 patients requiring cranioplasty. The advantages and limitations of fast-setting hydroxyapatite cement will be discussed.
Teichoic Acid Phosphorylcholine Esterase (1974)

A mutant of pneumococcus which lacks most of the usual autolysin (N-acetylmuramyl-l-alanine amidase), contains another enzyme that can remove a maximum of 15 to 20% of phosphorylcholine residues from pneumococcal cell walls and from the Forssman antigen. An identical enzymatic activity was found to be also present in the wild type of pneumococcus.