gebhart/patrepeval huggingface dataset:
Vibroacoustic frequency sweep analysis using automated multi-level substructuring (1999)

An algorithm for frequency sweep analysis of complex structures interacting with a light acoustic fluid is presented. The structure finite element model is transformed to a very efficient representation, in terms of eigenvecton for thousands of substructures on dozens of levels, using Automated Multi-Level Substructuring. Response of the fluid is in terms of the fluid’s modes of vibration, calculated from a fluid finite element representation in terms of nodal pressures. The sweep algorithm uses a two-part representation of the response. The first part includes the response of low-frequency global structure modes, approximated in terms of substructure modes, and nearly resonant fluid modes. The second part includes the response of all substructure modes and all non-resonant fluid modes, up to appropriate cutoff frequencies.
Near-Sun Free-Space Optical Communications from Space (2006)

Free-space optical communications offers expanded data return capacity, from probes distributed throughout the solar system and beyond. Space-borne and Earth-based optical transceivers used for communicating optically, will periodically encounter near-Sun pointing. This will result in an increase in the scattered background-light flux, often contributing to degraded link performance. The varying duration of near-Sun pointing link operations relative to the location of space-probes, is discussed in this paper. The impact of near-Sun pointing on link performance for a direct detection photon-counting communications system is analyzed for both ground- and space-based Earth receivers. Finally, the impact of near-Sun pointing on space-borne optical transceivers is discussed
820. Infra-red spectrum of crystalline potassium perchlorate. Reassignment of the lower fundamental frequencies of the perchlorate ion (1952)

H. Cohn, J. Chem. Soc., 1952, 4282 DOI: 10.1039/JR9520004282
Clinical functional genomics (2005)

The goal of clinical functional genomics is to use genetic variation to identify disease mechanisms and possible therapeutic targets. The tractable nature of nucleic acids analysis and the recent improvements in automated sequencing methodologies means it is usually easier to identify gene defects that associate with heritable diseases than the consequences of these changes. Having identiﬁed a sequence variation associated with a clinical phenotype, it is necessary to ascertain whether this change is responsible for the disease and, if so, how does the variant contribute to the disease mechanism.
Development of wheelchair with assistive power unit (1994)

A wheelchair with an assistive power unit employing a differential gear is now under development. The wheelchair is specially aimed at those who have little residual power to drive a manual wheelchair, but often use a powered wheelchair. People who have C5 or C6 level spinal cord injury or the aged who have lower limb impairment are initially considered. The purpose is to encourage them to keep their residual ability or even to improve it by adjusting the assistive power. In addition to performance tests following JIS test procedures, 11 subjects, manual wheelchair users, tried the prototype and found its operation easy and that it is helpful while ascending or descending a slope. >
Measurement of Skull Bone Thickness for Bone-Anchored Hearing Aids (2010)

The SonoPointer is a promising, noninvasive, hand-held tool for real-time measurement of bone thickness in bone-anchored hearing aid surgery, especially for children. Even disregarding the absolute thickness reading, the SonoPointer could be used to search intraoperatively for a local maximum of bone thickness.
Proportion of cervical excision for cervical intraepithelial neoplasia as a predictor of pregnancy outcomes (2014)

The pretreatment cervical dimensions and the proportions of the volume/length excised vary substantially, and the latter correlates with the pregnancy duration. Assessment of the proportion excised might help to stratify women at risk who need intensive surveillance when pregnant.
The preparation, characterisation and structure of Ca8[AlO2]12Te2 and Cd8[AlO2]12Te2; two new members of the sodalite family (1998)

Two new aluminate sodalites containing the telluride ion have been synthesised for the first time. The structures of Ca8 [AlO2 ]12Te2 and Cd8 [AlO2 ]12Te2 have been determined using the Rietveld refinement of powder X-ray diffraction data. 125Te and 27Al MAS NMR and IR spectroscopy have been used to investigate the effect of the large occluded ion on the framework moiety.
Therapeutic vaccination with an autologous TriMix-Dendritic cell vaccine combined with sequential interferon alfa-2b in patients with advanced melanoma (2009)

9024 Background: Electroporation of dendritic cells (DC) with mRNA encoding fusion-proteins of a HLA-class II targeting signal and a melanoma associated antigen (MAA) together with mRNA encoding CD40 ligand, a constitutively active TLR4 and CD70 (TriMix) improves the immunostimulatory capacity of autologous DC. Methods: Following leukapheresis, immature DCs (derived from adherent PBMC cultured for 6 days in IL-4 / GM-CSF supplemented medium) are electroporated with mRNA encoding MAGE-A3, MAGE-C2, Tyrosinase and gp100 linked to DC-LAMP, and TriMix mRNA. TriMix-DC (12.5 10 6 /antigen) are cryopreserved and administered by 4 ID-injections q2w, and q8w thereafter. After the 4 th vaccination, interferon alfa-2b (IFN- a2b, 5 MIU TIW) is initiated. Immune monitoring is performed by skin biopsy of a vaccine injection site. Biopsies are investigated by IHC and by analyzing the activation (CD137+), cytolytic capacity (CD107a+), and cytokine release (IFN-γ and TNF-α) of DTH infiltrating T-cells in response to autologous EBV-B cells expressing MAA. Results: 29 pts (17M/12F; med age 49, range 28–75) with stage III/IV melanoma, nl LDH, and no CNS metastases were recruited. Vaccine related AE's (first 24 pts): gr2 local injection site reactions (all pts); fever & lethargy (gr2, 1 pt). Pts (20) who initiated IFN-a2b experienced constitutional side effects (gr3, 1 pt). Vaccine-specific DTH infiltrating T cells were documented post-vaccination in 13/17 pts (10/13 pts had a CD137+CD8+ and 2/13 pts a CD4+ response). Out of the 11 pts without evaluable disease, 2 had a local recurrence (salvaged by surgery). After a mFU of 7.8 mths (range 4.3–13.7) all pts remain disease-free. Out of the 13 pts with measurable disease, BOR (RECIST) was 8 SD and 5 PD; 1 pt with initial PD subsequently obtained a PR. Regression of metastases occurred in lung- (2 pts), orbita- (1 pt) and lymph node metastases (3 pts). After a mFU of 7 mths (range 1–14), the mPFS is 3,1 mths (95% CI 2,29–4,08); 4 pts remain progression-free after respectively 5, 8, 10 and 11 mths of follow-up. Conclusions: Therapeutic vaccination with TriMix-DC combined with sequential IFN-a2b is feasible, safe, immunogenic and associated with anti-tumor activity in patients with advanced melanoma. [Table: see text]
Full-vectorial imaginary-distance BPM analysis of eigenmodes of a light-guiding metal line loaded on a dielectric substrate (2005)

Characteristics of a light-guiding metal line loaded on a dielectric substrate are investigated through the eigenmode analysis using the full-vectorial imaginary-distance BPM. Numerical results are compared with those obtained from the semi-vectorial BPM. Directional couplers composed of parallel light-guiding metal lines are also studied.
Measuring electron densities in highly collisional plasmas using a 110 GHz interferometer (2002)

Summary form only given, as follows. A 110 GHz interferometer is used to measure electron densities in a highly collisional plasma. The plasma is formed and maintained with a helical coil driven at 13.56 MHz. In this regime, the background pressure approaches atmospheric pressure, and the collisionality is of the order /spl nu//sub e-n//spl ap/10/sub 9/-10/sup 13/. Probe measurements in this pressure range are inaccurate and unreliable due to complicated effects that electron-neutral collisions have in the sheath. It is necessary to operate an interferometer at a frequency high enough that the dominant characteristic frequency is the operating frequency (/omega>/spl nu//sub e-n/) yet low enough that small phase changes can be detected as a wave passes through the plasma. In this experiment, plasma dimensions are of the order 5-10 cm. In addition, the inelastic nature of collisions in this experiment make it necessary to interpret small phase changes with great care. A model has been developed help in that interpretation. Typical operating parameters are pressures of 1-700 Torr, applied magnetic field of 0-1000 Gauss, operating gasses of nitrogen, oxygen, argon, and air, and input RF power levels of 100-3000 Watts.
Ontology-driven query expansion methods to facilitate federated queries (2010)

In view of the need for a highly distributed and federated architecture, a robust query expansion in a specific domain has great impact on the performance of information retrieval. We aim to determine robust expansion terms using different weighting techniques and finding out the most k-top relevant terms. For this, first, we consider each individual ontology and user query keywords to determine the Basic Expansion Terms (BET) using a number of semantic measures namely Density Measure (DM), Betweenness Measure (BM), and Semantic Similarity Measure (SSM). Second, we specify New Expansion Terms (NET) by Ontology Alignment (OA). Third, we weight expanded terms using a combination of these semantic measures. Fourth, we use a Specific Interval(SI) to determine a set of Robust Expansion Terms (RET). Finally, we compare the result of our novel weighting approach with existing expansion approaches and show the effectiveness of our robust expansion in federated architecture.
Fetal T-Lymphocyte Subpopulations in Normal Pregnancies (1992)

Peripheral blood T lymphocyte subpopulations were measured, using a fluorescence-activated cell sorter, in fetal blood samples obtained either by cordocentesis (n = 118) or at elective caesarean section (n = 14). Both the numbers and percentages of the total T lymphocytes (CD3+) and T-helper lymphocytes (CD4+) increased exponentially with gestation from respective means of 46% (1.15 x 10(9)/l) and 29% (0.70 x 10(9)/l) at 16 weeks to a plateau of 75% (3.11 x 10(9)/l) and 54% (2.10 x 10(9)/l) at 34 weeks. Similarly, the number of suppressor/cytotoxic T lymphocytes (CD8+) increased linearly with gestation from a mean of 22% (0.55 x 10(9)/l) at 16 weeks to 24% (0.96 x 10(9)/l) at 40 weeks; there were no natural cytotoxic T lymphocytes (CD3+CD56+) in any of the fetal blood samples. The helper-to-suppressor T lymphocyte ratio (CD4/CD8) increased exponentially with gestation from a mean of 1.22 at 16 weeks to 2.57 at 28 weeks. The alterations in T lymphocyte subpopulations were accompanied by changes in the expression of CD45RA, L-selectin, CD25 and HLA-DR. These alterations in T lymphocyte subpopulations with gestation reflect the pattern of maturation and development of the fetal cell-mediated immune system.
Upper Atmospheric Temperatures and Excited State Densities from Spire Earth-Limb Infrared Radiances (1983)

High altitude measurements of spectrally-resolved atmospheric infrared fluorescence provide the necessary input for upper atmospheric model verification and refinement. Perhaps the most definitive survey of infrared radiance in the quiescent upper atmosphere was completed in the SPIRE measurement program conducted by the Air Force Geophysics Laboratory. In this mission a rocketborne instrumentation package was launched into the dawn terminator over Poker Flats, Alaska, in September of 1977. The goal of the program was to measure the atmospheric limb infrared radiance for tangent heights between hard earth and 250 km under both sunlit and dark conditions. To achieve this, the payload was sequentially scanned through the earth limb and was oriented at different angles relative to the sun. In this manner regions with a variety of illumination times were observed. One of the diagnostics employed on this flight was a liquid-helium-cooled circular variable filter (CVF) spectrometer capable of monitoring long-wavelength infrared emission in the 8.7 - 16.5 μm region with a spectral resolution of approximately 2% of the wavelength.
Specificity versus Redundancy of Melanocortins in Nerve Regeneration (1994)

The results of the present study demonstrate that administration of the ACTH-(4-9) analogue Org 2766 acutely enhances behavioral, morphological, and biochemical recovery after nigrostriatal destruction. Animals treated with Org 2766 (10 micrograms/kg every 24 hr) demonstrated an acceleration of denervation supersensitivity and a significantly decreased ipsilateral rotational response, as compared to their saline counterparts. Upon evaluation of the mesolimbic DA system using open field behavior, peptide-treated rats demonstrated a compensatory response in their rearing behavior. Furthermore, tyrosine hydroxylase immunocytochemical analysis indicated an enhanced staining in the Org 2766-treated groups. This evaluation was confirmed and quantified using specific high-affinity dopamine uptake. The brains of animals treated with Org 2766 maintained higher uptake levels, suggesting a greater fiber density than the saline-treated animals. Although recovery via reinnervation is very unlikely in this short period of time, improved recovery may be the result of a protective effect of Org 2766 after administration of 6-OHDA into the substantia nigra. Thus, it appears that Org 2766 provides the rapid effects in this system, by both accelerating some compensatory mechanisms necessary for functional recovery and promoting cell survival by providing neuronal protection. However, it does not appear that this protection is due to NMDA receptor manipulation. Org 2766 neither mimicked the NMDA antagonist MK-801 behaviorally nor biochemically in binding displacement studies. Interestingly, other studies have suggested that only the full ACTH molecule, and fragments larger than ACTH-(1-17), demonstrated binding activity at micromolar concentrations, whereas the shorter, noncorticotropic fragments were either less active or inactive (Table 2). As for ACTH-(4-10) immunoreactivity, it appears that this neurotrophic fragment of ACTH reappears in adults following injury to the nigrostriatal system. In addition, the systemically administered ACTH-(4-9) analogue, Org 2766, seems to be gaining access to the CNS, but is only effective in the injured system. Therefore, based on the immunocytochemical localization of the ACTH-(4-10) fragment in neonatal brains and in the injured adult rat CNS, the interesting possibility may be raised that endogenous ACTH peptides appear during both ontogeny and regeneration. These studies demonstrate once again that biological responses to the family of ACTH/MSH peptides depend on the specific peptide fragment administered, its dosage, and the timing of the administration. Consequently, since early intervention is of vital importance in CNS recovery processes, synergistic administration of ACTH fragments and other neurotrophic agents may offer a viable approach with which to combat degeneration in the CNS.
Antibody to Varicella-Zoster Virus Immediate-Early Protein 62 Augments Allodynia in Zoster via Brain-Derived Neurotrophic Factor (2009)

Varicella-zoster virus (VZV) expresses immediate-early protein 62 (IE62), and zoster is associated with neuropathic pain. Brain-derived neurotrophic factor (BDNF) is involved in the neuronal mechanism underlying pain hypersensitivity. Zoster is associated with prodrome and the robust production of booster antibody to VZV. We hypothesized that the intrathecal production of antibody to IE62 cross-reacting with BDNF and the nerve injury by skin lesions may augment allodynia in zoster by enhancing BDNF activity. One of three monoclonal antibodies against the 268-556 peptide of IE62 recognized BDNF. Immunological cross-reactivity between IE62 and BDNF and the effects of anti-IE62 monoclonal antibody (anti-IE62 MAb) cross-reactivity with BDNF on BDNF activity in cultured neurons were examined. Anti-IE62 MAb and anti-BDNF MAbs recognized the 414-429 peptide of IE62 and the BDNF dimer. Anti-IE62 MAb significantly augmented BDNF-related transcription in neurons and the morphological development of spinal dorsal horn neurons. Sera from patients recognized IE62 and BDNF and enhanced BDNF activity in neurons. The effect of anti-IE62 antibody on mechanical allodynia was characterized by the threshold of allodynia using von Frey filaments in a spinal nerve injury (SNI) in mice. The administration of anti-IE62 MAb to or immunization with cross-reacting IE62 protein to mice significantly enhanced mechanical allodynia on the side with SNI but not on the uninjured side. Anti-IE62 antibody augmented BDNF activity in neurons and allodynia in mice with SNI. The intrathecal production of anti-IE62 antibody augmenting BDNF activity and peripheral nerve injury by zoster may participate in the pathogenesis of allodynia in zoster.
Cytoplasmic and nuclear quality control and turnover of single-stranded RNA modulate post-transcriptional gene silencing in plants (2013)

Eukaryotic RNA quality control (RQC) uses both endonucleolytic and exonucleolytic degradation to eliminate dysfunctional RNAs. In addition, endogenous and exogenous RNAs are degraded through post-transcriptional gene silencing (PTGS), which is triggered by the production of double-stranded (ds)RNAs and proceeds through short-interfering (si)RNA-directed ARGONAUTE-mediated endonucleolytic cleavage. Compromising cytoplasmic or nuclear 5'-3' exoribonuclease function enhances sense-transgene (S)-PTGS in Arabidopsis, suggesting that these pathways compete for similar RNA substrates. Here, we show that impairing nonsense-mediated decay, deadenylation or exosome activity enhanced S-PTGS, which requires host RNA-dependent RNA polymerase 6 (RDR6/SGS2/SDE1) and SUPPRESSOR OF GENE SILENCING 3 (SGS3) for the transformation of single-stranded RNA into dsRNA to trigger PTGS. However, these RQC mutations had no effect on inverted-repeat-PTGS, which directly produces hairpin dsRNA through transcription. Moreover, we show that these RQC factors are nuclear and cytoplasmic and are found in two RNA degradation foci in the cytoplasm: siRNA-bodies and processing-bodies. We propose a model of single-stranded RNA tug-of-war between RQC and S-PTGS that ensures the correct partitioning of RNA substrates among these RNA degradation pathways.
Dynamics of dentoalveolar ankylosis and associated root resorption (1989)

Abstract The present experimental studies in monkeys were undertaken to study the initiation and progression of dentoalveolar ankylosis of replanted teeth and associated root resorption. Maxillary and mandibular lateral incisors were extracted and replanted after an extraoral period of 15 min or 1 h. Teeth with an extraoral period of 1 h were endodontically treated. Half the number of monkeys were given antibiotics at the time of replantation. The observation periods varied from 2 days to 40 weeks. Irrespective of the length of the extraoral period, initial root resorption and minor areas of ankylosis were found 1 week after replantation. The initial ankylosis was not preceded by root resorption. In teeth replanted after an extraoral period of 15 min the ankylotic area did not increase with increasing time after replantation. Instead the periodontal membrane was re‐established, separating the root surface from the alveolar bone. In teeth replanted after an extraoral period of 1 h, the initial ankylotic area increased with increasing time after replantation. Eight weeks and more after replantation, most of the periodontal membrane was replaced by bone covered by osteoblasts and occasional osteoblasts that were in continuity with the endosteal cells outlining the marrow spaces of the alveolar bone. The cementum and dentin were then gradually resorbed with increasing time after replantation. Antibiotics given at the time of replantation reduced the initial inflammation in the periodontal membrane and the inflammatory root resorption after all observation periods and it also seemed to some extent to prevent bacteria from entering the necrotic pulp tissue. Based on the present results it is suggested that root resorption associated with dentoalveolar ankylosis is initiated by endosteal osteoblasts and is thus a hormonally regulated process. This is in contrast to inflammatory root resorption, which seems to be triggered by inflammatory cells.
Introduction des facettes articulaires dans une modélisation par éléments finis de la colonne vertébrale et du thorax scoliotique : aspects mécaniques (1995)

Un modele par elements finis du rachis dorso-lombaire et du thorax a ete construit afin d'etudier les deformations scoliotiques. La geometrie a ete introduite a partir de reconstructions stereoradiographiques et de coupes tomographiques. L'arc posterieur a ete modelise en introduisant plusieurs ligaments et les facettes articulaires. Ces dernieres ont ete modelisees a l'aide de surfaces geometriques simples (plans, cylindres) et en utilisant des elements de contact entre un point et une surface qui permettent un guidage cinematique. Ce modele par elements finis a ete valide en comparant des experimentations in-vitro sur 6 unites fonctionnelles (T3-T4, T7-T8, T12.L1) a des simulations sur des unites fonctionnelles issues du modele. Plusieurs tests ont ete effectues en flexion, extension, inclinaison laterale et torsion sur l'unite fonctionnelle complete, l'unite fonctionnelle sans facettes articulaires et la partie anterieure seule. Les resultats fournis par le modele restent dans le couloir experimental. L'utilisation du modele a permis de mettre en valeur le role du disque intervertebral, des ligaments intervertebraux et des facettes articulaires. D'autres travaux sont en cours afin de comparer les resultats du modele a des mesures in-vivo. Ce modele par elements finis permettra a moyen terme de simuler des tests cliniques, des interventions chirurgicales et aussi de mieux comprendre les phenomenes mecaniques qui regissent les deformations scoliotiques.
Phase Change in Adsorbed Helium at Low Temperature (1965)

Several recent reports indicate a growing interest in the properties of adsorbed helium at low temperatures. This interest is based on the expected influence of restrictions of mobility and dimensions on thermodynamic properties such as heat capacity,(1,2) adsorption isotherms,(3) magnetic susceptibility,(4-6) and nuclear polarization.(7) This Letter presents specific heat data for adsorbed helium in the temperature range from 0.25 to 4°K, at several partial monolayer coverages. We interpret the results as indicating the existence of two surface phases. \n\nSee Also:\nErratum: D. L. Goodstein, J. G. Dash, and W. D. McCormick, Phase Change in Adsorbed Helium at Low Temperature., Phys. Rev. Lett. 15, 740 (1965).
Distribution of guidance models for cardiac resynchronization therapy in the setting of multi-center clinical trials (2014)

Multi-center trials provide the unique ability to investigate novel techniques across a range of geographical sites with sufficient statistical power, the inclusion of multiple operators determining feasibility under a wider array of clinical environments and work-flows. For this purpose, we introduce a new means of distributing pre-procedural cardiac models for image-guided interventions across a large scale multi-center trial. In this method, a single core facility is responsible for image processing, employing a novel web-based interface for model visualization and distribution. The requirements for such an interface, being WebGL-based, are minimal and well within the realms of accessibility for participating centers. We then demonstrate the accuracy of our approach using a single-center pacemaker lead implantation trial with generic planning models.