gebhart/patrepeval huggingface dataset:
Performance of dairy cows fed silage and grain produced from second-generation insect-protected (Bacillus thuringiensis) corn (MON 89034), compared with parental line corn or reference corn (2014)

Corn grain and corn silage are major feed components in lactating dairy cow rations. Bacillus thuringiensis (B.t.) is a naturally occurring soil bacterium that produces a protein that is toxic to lepidopteran insects that may damage plant tissues and reduce corn quality and yields. During each of the four 28-d periods, cows were offered 1 of 4 rations in which the corn grain and silage originated from different corn hybrids: a nontransgenic corn control (from hybrid DKC63-78; Monsanto Co., St. Louis, MO), a B.t. test substance corn (MON 89034 in hybrid DKC63-78; Monsanto Co.), and 2 commercial nontransgenic reference (Ref) hybrids: DKC61-42 (Ref 1) and DKC62-30 (Ref 2; Monsanto Co.). Sixteen multiparous Holstein cows averaging 110 ± 21 d in milk and weighing 684 ± 62.3 kg were blocked by days in milk and milk yield and randomly assigned to one of four 4 × 4 Latin squares. Diets were formulated to contain 36.4% corn silage and 16.3% corn grain. Dry matter intake was greater for cows consuming B.t. corn (26.6 ± 0.59 kg/d) compared with the control, Ref 1, and Ref 2 corn diets (25.4, 25.0, and 25.6 ± 0.59 kg/d, respectively). Milk yield, fat yield, and percentage of fat (36.8 ± 0.98 kg/d, 1.22 ± 0.05 kg/d, and 3.3 ± 0.10%), milk protein yield and percentage of protein (1.11 ± 0.03 kg/d and 3.01 ± 0.05%), milk urea nitrogen concentration (14.01 ± 0.49 mg/dL), and 3.5% fat-corrected milk yield (35.7 ± 1.07 kg/d) were not different across treatments. The results from this study show that lactating dairy cows that consume B.t. corn (MON 89034) do not differ from lactating dairy cows that consume nontransgenic corn in milk yield, 3.5% fat-corrected milk per unit of dry matter intake, or milk components.
Electrostatic contributions to solvation energies: comparison of free energy perturbation and continuum calculations (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrostatic contributions to solvation energies: comparison of free energy perturbation and continuum calculationsArald Jean-Charles, Anthony Nicholls, Kim Sharp, Barry Honig, Anna Tempczyk, Thomas F. Hendrickson, and W. Clark StillCite this: J. Am. Chem. Soc. 1991, 113, 4, 1454–1455Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/ja00004a079https://doi.org/10.1021/ja00004a079research-articleACS PublicationsRequest reuse permissionsArticle Views538Altmetric-Citations170LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Polymerase Chain Reaction Detection of HPV in Squamous Carcinoma of the Oropharynx (2010)

Human papillomavirus (HPV) testing is routinely performed on oropharyngeal carcinomas. We compared the Access Genetics (Minneapolis, MN) polymerase chain reaction (PCR) assay (AGPCR), DNA-DNA in situ hybridization (ISH; Ventana, Tucson, AZ), and HPV-16 E7 PCR amplification in consecutively accessioned oropharyngeal cancers. We tested 126 cases by both PCR methods; 102 were positive by either for a maximum positive rate (MPR) of 81.0%. Relative to the MPR, the sensitivities of AGPCR and E7 PCR were 90.2% and 72.5%, respectively. Of 17 AGPCR+ cases tested by ISH, 14/14 unequivocally positive/negative were concordant. All cases (97/97) positive by either PCR assay were positive for p16. There was no relationship between level of histologic differentiation and HPV status. ISH and AGPCR have comparable performance for the detection of HPV in oropharyngeal carcinomas. PCR is a suitable and economical assay that is comparable to ISH in sensitivity and may provide logistical advantages relative to ISH for assessing HPV status in oropharyngeal malignancies. However, it is imperative that appropriate sensitivity controls be in place for such assays.
Safety and efficacy of long-term etanercept in the treatment of methotrexate-refractory polyarticular-course juvenile idiopathic arthritis in Japan (2012)

Objectives Previous short-term trials found etanercept (0.2 or 0.4 mg/kg) to be effective and well tolerated in Japanese children with juvenile idiopathic arthritis (JIA) who were intolerant/resistant to methotrexate. The aim of this study was to evaluate the long-term safety and efficacy of etanercept in Japanese children with JIA. Methods Patients (4–19 years) who received etanercept in one of three short-term studies continued onto this long-term open-label study. Results Of the 32 patients enrolled, 18 (56.3%) completed 192 weeks of the study and 14 (43.8%) were discontinued; 7 (21.9%) for patient refusal, 2 (6.3%) for adverse events (AEs), and 5 (15.6%) for lack of efficacy. All patients reported AEs; 31 (96.9%) reported infections and 6 (18.8%) reported serious AEs. Main efficacy assessments included change from baseline in the American College of Rheumatology Pediatric core components, including mean improvements from baseline in the physician global assessment (90.7%), patient/guardian global assessments (54.1%), Childhood Health Assessment Questionnaire (84.6%), and median improvements in C-reactive protein levels (92.7%). No unexpected safety results were reported, and early efficacy responses were sustained in the long term. Conclusions This study provides further evidence that etanercept is an effective therapeutic option for Japanese children with polyarticular-course JIA.
Optimal Resource Allocation in Presidential Primaries (1980)

Abstract A model for the optimal allocation of resources in presidential primaries is described, under the assumption that two candidates seek to maximize their expected delegate vote in a sequential game that allows for momentum transfer from earlier to later contests. Specifically, the model assumes that the probability that a voter in a primary state votes for a particular candidate is a function of both the resources that candidate and his opponent allocate to that primary and their performances in the immediately preceding primary - and indirectly on all earlier primaries. Given that the candidates make equal (optimal) allocations to each primary, a local maximum, which heavily emphasizes the earlier primaries, is found. Several modifications in the basic model are discussed. Preliminary financial expenditure data are used to test the basic model for the 1976 primaries, and some cursory comparisons with 1980 are made. Possible normative implications of changes in the primary rules are briefly considered, particularly with respect to inequities the present rules seem to engender.
Multiwavelength Spectrophotometric Resolution of the Micro-Equilibria of Cetirizine (2001)

The acid-base properties of the antihistamine (H receptor antagonist) cetirizine have been studied by using a previously developed multiwavelength spectrophotometric titration method. A new computational procedure called “Two-Step-Divide-and-Conquer” (TSDC), which applied evolving factor analysis (EFA) and target factor analysis (TFA), has been derived to unravel the micro-equilibria of the triprotic zwitterionic compound from the spectral data. We have demonstrated that a single spectrophotometric titration experiment is sufficient to determine the 12 unknown microconstants and the distribution of microspecies, which are in good agreement with literature, where available.
Nanomaterials in the environment: Behavior, fate, bioavailability, and effects (2008)

The recent advances in nanotechnology and the corresponding increase in the use of nanomaterials in products in every sector of society have resulted in uncertainties regarding environmental impacts. The objectives of this review are to introduce the key aspects pertaining to nanomaterials in the environment and to discuss what is known concerning their fate, behavior, disposition, and toxicity, with a particular focus on those that make up manufactured nanomaterials. This review critiques existing nanomaterial research in freshwater, marine, and soil environments. It illustrates the paucity of existing research and demonstrates the need for additional research. Environmental scientists are encouraged to base this research on existing studies on colloidal behavior and toxicology. The need for standard reference and testing materials as well as methodology for suspension preparation and testing is also discussed.
Association of Diabetic Status and Glycemic Control With Ischemic and Bleeding Outcomes in Patients With Stable Coronary Artery Disease: The 5‐Year CORONOR Registry (2018)

The 5-year increased risk of ischemic events in patients with stable coronary artery disease with diabetes mellitus was restricted to those with HbA1c ≥7%. By contrast, the increase in bleeding risk associated with diabetes mellitus was observed in patients with HbA1c ≥7% and in patients with HbA1c <7%. The level of HbA1c should be taken into account for future research and may help physicians to manage prolonged antithrombotic therapies in this high-risk subgroup.
Developmental software environment that is applicable to small-size humanoids and life-size humanoids (2002)

In this paper, the developmental software environment for humanoids is introduced. This environment has the following features: 1) a hardware concealment function which saves the trouble with hardware improvements; 2) an incremental expansion function which supports a long-term development by many developers; and 3) a centralised management of body information which enables the robots to share software among different bodies. These features are realized by the plug-in architecture, the universal robot model and its compilers. Using plug-ins enables one to accumulate functions developed by different developers and to switch computer interfaces of the robot body. The universal robot model and compilers promote the use of external software and share software modules among different bodies.
Reuse of Structural Volume Test Methods for In-System Testing of Automotive ASICs (2012)

The automotive industry has to deal with an increasing amount of electronics in today's vehicles. This paper describes the advantages of structural tests during in-field system test, reusing existing test data and on-chip structures. Demonstration is the embedded test of an ASIC within an automotive control unit, utilizing manufacturing scan-tests.
A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis (2005)

A conditional-lethal recombinant virus was constructed in which the expression of the vaccinia virus I7L gene is under the control of the tetracycline operator/repressor system. In the absence of I7L expression, processing of the major VV core proteins is inhibited and electron microscopy reveals defects in virion morphogenesis subsequent to the formation of immature virion particles but prior to core condensation. Plasmid-borne I7L is capable of rescuing the growth of this virus and rescue is optimal when the I7L gene is expressed using the authentic I7L promoter. Taken together, these data suggest that correct temporal expression of the VV I7L cysteine proteinase is required for core protein maturation, virion assembly and production of infectious progeny.
Compensating Respiratory Motion in PET Image Reconstruction Using 4D PET/CT (2006)

Respiratory motion of the patient can cause image blur and inaccurate radioactivity quantification in PET imaging. Gated PET acquisition freezes the motion but suffers in image quality due to insufficient photon statistics. We present in this paper a novel approach that incorporates motion information into the reconstruction process and reconstruct the motion-free image with all data acquired. Computer simulation and phantom study showed good motion compensation capability of this algorithm, with no obvious motion artifacts visible on the reconstructed image
Reform the People: Changing Attitudes towards Popular Education in Early Twentieth-Century China (1992)

The re-orientation of official thinking the public debate 1900-1911 popular education developments 1904-1911 the 1912 school system popular educational developments in the early Republic the work-study movement.
Analysis of the Elements of Catabolite Repression in <i>Clostridium acetobutylicum</i> ATCC 824 (2003)

The PTSH gene, encoding the phosphotransferase protein HPr, from Clostridium acetobutylicum ATCC 824 was identified from the genome sequence, cloned and shown to complement a PTSH mutant of Escherichia coli. The deduced protein sequence shares significant homology with HPr proteins from other low-GC gram-positive bacteria, although the highly conserved sequence surrounding the Ser-46 phosphorylation site is not well preserved in the clostridial protein. Nevertheless, the HPr was phosphorylated in an ATP-dependent manner in cell-free extracts of C. Acetobutylicum. Furthermore, purified His-tagged HPr from Bacillus Subtilis was also a substrate for the clostridial HPr kinase/phosphorylase. This phosphorylation reaction is a key step in the mechanism of carbon catabolite repression proposed to operate in B. Subtilis and other low-GC gram-positive bacteria. Putative genes encoding the HPr kinase/phosphorylase and the other element of this model, namely the catabolite control protein CcpA, were identified from the C. Acetobutylicum genome sequence, suggesting that a similar mechanism of carbon catabolite repression may operate in this industrially important organism.
Non-specific Adsorption of Interferon to Immobilized Serum Immunoglobulin (1979)

Human leukocyte interferon attaches to hyperimmune serum immunoglobulins, coupled to agarose, even though the antibodies are not specific for interferon. Unless it is first washed off with ethylene glycol, the attached interferon elutes together with immune-specific antigens during immuno-affinity chromatography.
Synchronization between Respiration and Mastication Functional Coordination of Respiratory and Digestive Systems (2018)

The purpose of our study is to evaluate the relationship between respiratory period and chewing period. In 10 healthy peoples (6 males and 4 females, age 26 7 years), EMG of masticatory muscles and respiratory curve during chewing of gum were measured and synchronicity between respiration and chewing were analyzed using the phase of chewing occurring within respiratory period. Results, the coherence between the two signals at the peak frequency of respiration was 0.06 0.03 (mean SD). In all subjects, the relationship between respiration period and chewing period was random and was not correlated. In this experiment, chewing period wasn't controlled. Therefore, it is considered that respiration may have been synchronized if the period of chewing was controlled.
Gating as a Control Element in Constrictive Binding and Guest Release by Hemicarcerands (1996)

Theoretical modeling of the dynamics of complexation and decomplexation of guest molecules by container molecules reveals that gating has a critical influence on the ease of formation and stability of host-guest complexes. Hosts equipped with gates can form very stable complexes with a variety of guests under readily achievable conditions. Gating involves conformational processes of the host molecule that alter the size of the portals through which guest molecules pass. "French door" and "sliding door" mechanisms of gate opening are identified.
Construction of fair surfaces over irregular meshes (2001)

This paper describes the process of constructing a fair, open or closed C1 surface over a given irregular curve mesh. The input to the surface construction consists of point and/or curve data which are individually marked to be interpolated or approximated and are arranged according to an arbitrary irregular curve mesh topology. The surface constructed from these data will minimize flexibly chosen fairness criteria. The set of available fairness criteria is able to measure surface characteristics related to curvature, variation of curvature and higher order surface derivatives based on integral functionals of quadratic form derived from the second, third and higher order parametric derivatives of the surface. The choice is based on the desired shape character.
SITE OF INFLUX OF INFLAMMATORY WHITE CELLS INTO A REJECTING RAT RENAL ALLOGRAFT (1989)

In this paper we demonstrate that the vascular endothelium of a normal kidney and a syngeneic kidney graft binds only poorly syngeneic or allogeneic lymphocytes in an in vitro binding assay. On the contrary, the peritubular capillary endothelium of an allograft binds almost 7 times more lymphocytes than the peritubular capillary of a normal kidney. These findings suggest that the site of influx of inflammatory capillary white cells into the graft during rejection is the peritubular capillary endothelium.
A NEW METHOD FOR THE PRODUCTION OF RABBIT ANTIRAT LYMPHOCYTE SERUM (1969)

SUMMARY Rat lymphocytes, chemically cross linked with 1,5-difluoro-2,4-dinitrobenzene, when injected into rabbits, produced an antilymphocyte serum that was more avid and specific for lymphocytes as shown by several in vitro and in vivo systems than was antilymphocyte serum produced by standard methods. Chemically treated lymphocytes did not lyse in distilled water and, after prolonged storage at 4 C, did not show any change in antigenicity. Electron micrographs of treated lymphocytes and thymocytes, stored as long as 6 months at 4 C, showed little or no difference when compared to untreated cells obtained within 24 hr
Seasonal Changes in Distribution of Intercepted Photosynthetically Active Radiation for Layer and Dry Matter Production in Spring Wheat Canopy. (1993)

In order to understand the relationship between solar radiation and biomass production within crop canopies, penetration, reflection, and interception of photosynthetically active radiation (PAR) were measured in the canopy of a spring wheat variety called Haruyrutaka. The relationship was evaluated by looking at the plant and canopy architecture, the amount of intercepted PAR, the crop growth rate (CGR), and the conversion of PAR into dry matter (EPAR). The interception (%) of PAR increased rapidly from seedling emergence to flag leaf emergence. It was more than 90% from flag leaf emergence to maturity. Within the canopy, the interception of PAR by the ear was more than 30% after anthesis. The interception of the flag leaf increased from anthesis to milk ripe stage as the flag leaf reclined from an erect to a horizontal position. Interception decreased from the milk ripe stage to maturity as the flag leaf further drooped. Two regression lines fit the relationship between the amount of intercepted PAR by the living plant and the CGR for canopy. The slope of the line after heading was higher than the one before heading. This is because the ear covered the upper layer of the canopy so that assimilation increased under high PAR conditions and consumption increased under low PAR conditions. EPAR changed throughout the growing season as the plant and canopy configuration changed.
Li and F-bearing alkali amphibole from granitic pegmatite at Hurricane Mountain, Carroll County, New Hampshire (1996)

At Hurricane Mountain, Carroll County, New Hampshire, bodies of granitic pegmatite in riebeckite granite contain large (up to 10 cm long and 2 cm across) primary crystals of Li-bearing fluor-arfvedsonite in miarolitic cavities, grading to euhedral Li- and F-poor arfvedsonite. Fine-grained, fibrous, light blue-gray riebeckite occurs as a late-stage hydrothermal filling in the miarolitic cavities. The early, Li-rich, fluor-arfvedsonite has: a 9.836(5), b 17.997(7), c 5.316(4) Aa, beta 103.735(4) degrees , V 914.20(6) Aa 3 ; Z = 2, D (sub meas.) 3.34 g/cm 3 , D (sub calc.) 3.353 g/cm 3 ; biaxial (-), 2V (sub meas.) 44(1) degrees , 2V (sub calc.) 46 degrees ; alpha 1.681(2), beta 1.692(2), gamma 1.694(2), inclined dispersion, r>v; X / c-7 degrees , Y = b, Z / a+7 degrees ; X dark blue, Y lavender gray, Z pale yellowish brown; X>Y>Z; X is opaque at 0.03 mm thickness. A structural formula, on the basis of 24 (O, OH, F) atoms is: (Na (sub 0.86) K (sub 0.25) )Na 2 (Fe (super 2+) (sub 2.54) Fe (super 3+) (sub 1.485) Mn (sub 0.10) Zn (sub 0.02) Li (sub 0.49) Ti (sub 0.07) ) (Si (sub 7.71) Al (sub 0.07) )O 22 (F (sub 1.34) OH (sub 0.63) ). Arfvedsonite within the miarolitic cavities contains less Li and F than that of the earlier generation, and the still later riebeckite contains only 0.09 wt.% Li 2 O and 0.3 wt.% F. The Fe (super 3+) :Fe (super 2+) ratio of the early Li-bearing fluor-arfvedsonite and that of the euhedral arfvedsonite crystals within miarolitic cavities is 0.58. The late, fibrous, cavity-filling riebeckite has an Fe (super 3+) :Fe (super 2+) ratio of 0.99. The total iron content of the three amphiboles increases with continued crystallization. These amphiboles are products of peralkaline pegmatites locally derived from peralkaline granite.
Object‐oriented analysis of signalling and control in broadband networks (1994)

Abstract This paper analyses the problem of providing call, connection, channel, and service control in broadband and intelligent networks to support a wide variety of services. A formal methodology called object‐oriented analysis (OOA) is used to analyse this problem. Three types of OOA models are constructed: the information model, state models and the object communication model. From these models, a distributed call processing architecture that proposes separate servers for call control, connection control, channel control and service control, is derived. Based on the events used for inter‐object communication in the object communication model, service‐specific and control‐function specific application service elements are defined as client‐server based protocols.
Haplotype Analysis of the Promoter Region of Phosphodiesterase Type 8B ( <i>PDE8B</i> ) in Correlation with Inactivating <i>PDE8B</i> Mutation and the Serum Thyroid-Stimulating Hormone Levels (2010)

The proposed mechanism by which PDE8B may influence TSH levels is through control of cAMP signaling. Our analysis revealed separate segregation of an inactivating PDE8B allele from the high-TSH-allele and showed low TSH levels in persons who carry an inactivating PDE8B allele. These data suggest that, indeed, PDE8B may be involved in regulation of TSH levels.
The dog and rat olfactory receptor repertoires (2005)

We have established a complete or almost complete list of OR genes in the dog and the rat and have compared the sequences of these genes within and between the two species. Our results provide insight into the evolutionary development of these genes and the local amplifications that have led to the specific amplification of many subfamilies. We have also compared the human and rat ORs with the human and mouse OR repertoires.