gebhart/patrepeval huggingface dataset:
Real-Time PCR to Quantify<i>Leishmania donovani</i>in Hamsters (2013)

Visceral leishmaniasis, a vector-borne disease caused by Leishmania donovani and Leishmania infantum , currently affects 12 million individuals in 88 countries. In the present study, a real-time PCR (rt-PCR) assay has been optimized and validated against 2 other routine methods, i.e., microscopy and limiting dilution culture assay, to estimate parasite load in the liver of infected Syrian hamsters (Mesocricetus auratus). A set of specific primers amplified a 116-bp target template of the kinetoplastid DNA of L. donovani in a SYBR® Green-based rt-PCR assay. To assess the methods, we tested 2 anti-leishmanial compounds belonging to the class of arylimidamides, DB745 (2,5-bis[2-ethoxy-4-(2-pyridylimino)aminophenyl]furan) and DB766 (2,5-bis[2-(2-propoxy)-4-(2-pyridylimino)aminophenyl]furan) for efficacy in vivo in Syrian hamsters infected with L. donovani promastigotes. Parasite load was quantified in liver by all 3 methods and was found comparable. Of the 3 methods, rt-PCR was the fastest and most convenient, sensitive, and reproducible method.
Skeletal muscle as potential central link between sarcopenia and immune senescence (2019)

As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as sarcopenia and immune senescence respectively. The disease burden of these pathologies emphasizes the need for a better understanding of the underlying mechanisms. Skeletal muscle has emerged as a potent regulator of immune system function. As such, skeletal muscle might be the central integrator between sarcopenia and immune senescence in an aging biological system. Therapeutic approaches targeting skeletal muscle might be able to restore both muscle and immune system function. In this review, we therefore outline the current - however still fragmentary - knowledge about the potential communication pathways of muscle and immune system, how they are affected by aging of skeletal muscle and discuss possible treatment strategies. The review intends to be hypothesis-generating and should thereby stimulate further research in this important scientific field.
Development of microbolometer with high fill factor and high mechanical stability by shared-anchor structure (2012)

For the development of small microbolometer for mobile applications, new pixel design to enhance fill factor by sharedanchor structures is suggested and it can be possible to make a one anchor per unit pixel. Fill factor increases 10% more than that of normal unshared-anchor design. Amorphous-silicon based microbolometer has been fabricated with 64x64 arrays of 25um pixel size to verify proposed design. Mechanical flatness of shared-anchor structure is enhanced. Responsivity is enhanced from 1.08e+5 V/W to 1.23e+5 V/W due to the increase of fill-factor compared to unsharedanchor. There are no mechanical, electrical and thermal crosstalk problems with adjacent pixels.
Novel Application of Chemical Cold Packs for Treatment of Exercise-Induced Hyperthermia: A Randomized Controlled Trial (2015)

Application of CCP to glabrous skin surfaces was more effective for treating exercise-induced heat stress than the traditional CCP cooling intervention. This novel cooling technique may be beneficial as an adjunctive treatment for heat-related illness in the prehospital environment.
Diet Quality and Biomarker Profiles Related to Chronic Disease Prevention: The Multiethnic Cohort Study (2019)

<b>Objective:</b> To understand how diet quality affects chronic disease etiology, the associations of 4 <i>a priori</i> diet quality indices with blood levels of lipid-soluble micronutrients and biomarkers of inflammation, lipid, and glucose metabolism were examined in 5 ethnic groups.<b>Methods:</b> In a cross-sectional design, the Adiposity Phenotype Study, a subset of the Multiethnic Cohort in Hawaii and Los Angeles, recruited participants of white, African American, Native Hawaiian, Japanese American, and Latino ancestry. A total of 896 men and 910 women completed a validated quantitative food frequency questionnaire and anthropometric measurements and donated a fasting blood sample. Using general linear models, covariate-adjusted mean levels of lipid-soluble micronutrients (total carotenes, lycopene, total tocopherols, total lutein, cryptoxanthins), biomarkers of inflammation (C-reactive protein [CRP], tumor necrosis factor-[Formula: see text]), adipokines (adiponectin, leptin), lipids (total cholesterol, high-density lipoprotein cholesterol [HDL-C], triglycerides), and glucose metabolism (glucose, insulin, homeostatic model assessment of insulin resistance [HOMA-IR]) were computed across tertiles of 4 <i>a priori</i> dietary indices Healthy Eating Index (HEI)-2010, Alternative HEI (AHEI)-2010, alternate Mediterranean Diet (aMED), Dietary Approaches to Stop Hypertension (DASH); trends were evaluated in models with diet quality scores as continuous variables.<b>Results:</b> With better diet quality, levels of carotenes, lutein, cryptoxanthin, adiponectin, and HDL-C were significantly higher (<i>p</i><sub>trend</sub> < 0.01), whereas levels of CRP, leptin, total cholesterol, triglycerides, glucose, insulin, and HOMA-IR were inversely associated (<i>p</i><sub>trend</sub> < 0.05) with diet quality. With the exception of cryptoxanthins and triglycerides, the associations were consistent across ethnic groups.<b>Conclusions:</b> These findings confirm the association between diet quality and nutrition-related biomarkers and support the idea that a high-quality diet positively influences biologic pathways involved in chronic disease etiology across different ethnic groups.
Uteroglobin, a Possible Ligand of the Lipoxin Receptor Inhibits Serum Amyloid A-Driven Inflammation (2014)

Serum amyloid A (SAA) production is increased by inflamed arthritic synovial tissue, where it acts as a cytokine/chemoattractant for inflammatory and immune cells and as an inducer of matrix degrading enzymes. SAA has been shown to bind lipoxin A4 receptor, a member of the formyl-peptide related 2 G-protein coupled receptor family (ALX) and elicit proinflammatory activities in human primary fibroblast-like synoviocytes (FLS). We report on the identification of uteroglobin, a small globular protein with potent anti-inflammatory activities, as a possible ligand of ALX. Uteroglobin-specific association with ALX was demonstrated by an enzyme immunoassay experiment employing a cell line engineered to express the human ALX receptor. Uteroglobin's interaction with ALX resulted in the inhibition of SAA responses, such as attenuation of phospholipase A2 activation and cellular chemotaxis. In FLS, uteroglobin showed an antagonism against SAA-induced interleukin-8 release and decreased cell migration. These novel roles described for uteroglobin via ALX may help elucidate genetic and clinical observations indicating that a polymorphism in the uteroglobin promoter is linked to disease outcome, specifically prediction of bone erosion in patients with rheumatoid arthritis or severity of IgA glomerulonephritis and sarcoidosis.
FURTHER APPLICATION OF THE PKE-AVERAGE SPEED FUEL CONSUMPTION AND EMISSIONS MODEL (1982)

The pke-average speed model for predicting fuel consumption and exhaust emissions is modified to include running speed and stop delay time in place of average speed. Extension of the model to include non-linear terms in the pke domain in addition to the speed domain (up to 8 coefficients) is shown to increase the amount of variance explained in on-road fuel consumption data for one car, and in micro-trip analysis of chassis dynamometer tests for a range of vehicles. Correlation coefficients for the dynamometer fuel consumption results (which include alternative fuels to petrol - lp gas, compressed natural gas and distillate) are generally in excess of .98. Regression of emissions data show improvements in explained variance; up to 15 per cent for CO emissions, which have proven to fit the pke-average speed model less well than HC and NOx. Suggestions are made as to the suitability of ADR27A and other test cycles for model calibration (a). The paper was presented as Paper 9-- Session 3--Fuel Consumption Modelling (2) (SAE 82139). The number of the covering abstract of the conference is TRIS no. 367871. (TRRL)
Telomere loss, telomerase, and cancer (1995)

Abstract Telomeric DNA safeguards chromosomes from genetic damage and rearrangement. Normal somatic cells lose telomeric DNA with each division and during normal human aging. Immortal cancer cells typically express the enzyme telomerase, a ribonucleoprotein polymerase that adds new telomere repeats onto the chromosome ends. To study the role of telomerase in cancer cells, the RNA component of human telomerase (hTR) was recently cloned. HeLa cells expressing antisense hTR exhibited reduced telomerase activity, gradual loss of telomeric DNA, and cell death after 23–26 doublings. These results demonstrate that telomerase is a critical enzyme for the continued proliferation of metastatic tumor cells. Whereas telomere loss occurs in both normal and precancerous cells, telomere shortening with age can lead to genetic damage, which may underlie the age‐related increases in cancer rates. © 1995 Wiley‐Liss, Inc.
Clinical Care of the Diabetic Foot (2024)

Newly revised to reflect the latest Standards of Care in Diabetes, this fourth edition of Clinical Care of the Diabetic Foot is an essential guide for all clinicians, healthcare providers, and educators who help people with diabetes avoid and manage this challenging complication. This new edition addresses the full scope of treatment, including: Pathogenesis Screening and Risk Assessment Ulcer Assessment and Classification Adjunctive Wound Therapies Dressings and Local Wound Care Charcot Foot Soft Tissue Reconstruction Infection Peripheral Artery Disease Remission
HYPOADRENOTROPISM: THE ISOLATED DEFICIENCY OF ADRENOTROPIC HORMONE (1960)

Two patients with an isolated deficiency of adrcnotropic hormone are presented. One was a female patient, aged 58, who had a six-year history of profound weight loss, weakness and loss of axillary and pubic hair. The second was a male patient, aged 28, who suffered from weight loss, weakness and spontaneous hypoglycemic attacks. Neither patient had the hyperpigmentation characteristic of primary adrenal insufficiency and both were shown to have adrenal insufficiency that changed to a state of normal adrenal function during treatment with ACTH. Thyroidal and gonadal functions were normal. Neither patient had evidence of an intracranial tumor, and neither had received previous glucocorticoid therapy. The female patient died of adrenal insufficiency, and postmortem studies revealed small but intact adrenals, an intact pituitary and a normal hypothalamus. These patients suffered from a deficiency of circulating ACTH but the specific etiology of this deficiency is unknown.
Biosynthesis of Phosphatidylinositol (1981)

Conference Abstract| April 01 1981 Biosynthesis of Phosphatidylinositol S. Schmeisser; S. Schmeisser 1Robert Koch-Institut des Bundesgesundheitsamtes, Nordufer 20, D-1000 Berlin 65 Search for other works by this author on: This Site PubMed Google Scholar H. Diringer H. Diringer 1Robert Koch-Institut des Bundesgesundheitsamtes, Nordufer 20, D-1000 Berlin 65 Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 293P. https://doi.org/10.1042/bst009293pc Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation S. Schmeisser, H. Diringer; Biosynthesis of Phosphatidylinositol. Biochem Soc Trans 1 April 1981; 9 (2): 293P. doi: https://doi.org/10.1042/bst009293pc Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
A Review of: “Crafts and Creative Media in Therapy, 3rd edition (2007)” (2008)

The general purpose of this book Crafts and Creative Media in Therapy (2007) is to help students and practitioners value creative activities and restore them to their rightful place in occupational...
VALIDATION OF SEVERAL RECONSTRUCTION AND SIMULATION MODELS IN THE HVE (HUMAN-VEHICLE-ENVIRONMENT) SCIENTIFIC VISUALIZATION ENVIRONMENT (1996)

The Human-Vehicle-Environment (HVE) scientific visualization environment introduced motor vehicle safety researchers to a new paradigm for studying the cause of motor vehicle accidents. The open architecture of HVE provided access to several new and existing reconstruction and simulation models for both humans and vehicles. This paper provided a validation of four existing models: EDCRASH, EDSMAC, EDSVS, and EDVTS. Because these EDVAP models had previous validation studies, the results obtained in the HVE environment were limited to a comparison with those previous studies. The validation of the simulation models was extended to include three-dimensional environments. (A) For the covering abstract of the conference see IRRD 898597.
Relative proton affinity of argon and deuterium (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRelative proton affinity of argon and deuteriumMichael T. Bowers and Daniel D. EllemanCite this: J. Am. Chem. Soc. 1970, 92, 25, 7258–7262Publication Date (Print):December 1, 1970Publication History Published online1 May 2002Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/ja00728a005https://doi.org/10.1021/ja00728a005research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Distributed algorithms for secure multipath routing (2005)

To proactively defend against intruders from readily jeopardizing single-path data sessions, we propose a distributed secure multipath solution to route data across multiple paths so that intruders require much more resources to mount successful attacks. Our work exhibits several crucial properties that differentiate itself from previous approaches. They include (1) distributed routing decisions: routing decisions are made without the centralized information of the entire network topology, (2) bandwidth-constraint adaptation: the worst-case link attack is mitigated for any feasible session throughput subject to the link-bandwidth constraints, and (3) lexicographic protection: severe link attacks are suppressed based on lexicographic optimization. We devise two algorithms for the solution, termed the bound-control algorithm and the lex-control algorithm, and prove their convergence to the respective optimal solutions. Experiments show that the bound-control algorithm is more effective to prevent the worst-case single-link attack when compared to the single-path approach, and that the lex-control algorithm further enhances the bound-control algorithm by countering severe single-link attacks and various models of multi-link attacks. Moreover, the lex-control algorithm offers prominent protection after only a few execution rounds. Thus, system designers can sacrifice minimal routing security for significantly improved algorithm performance when deploying the distributed secure multipath solution.
Chlorambucil in Indolent Chronic Lymphocytic Leukemia (1998)

Chlorambucil does not prolong survival in patients with stage A CLL. Since deferring therapy until the disease progresses to stage B or C does not compromise survival, treatment of indolent CLL is unnecessary.
ADENO-ASSOCIATED VIRAL MEDIATED GENE TRANSFER INTO THE PANCREAS LEADS TO LONG-TERM AND LOCALIZED TRANSGENE EXPRESSION. (2000)

Liu, Chengyang1; Jiang, Kanli1; Deng, Shaoping1; Gelman, Andrew1; Liu, Wenying1; Shaked, Abraham1; Brayman, Kenneth L.1 Author Information
ChemInform Abstract: ANTITUMOUR IMIDAZOTETRAZINES. 1. SYNTHESIS AND CHEMISTRY OF 8‐CARBAMOYL‐3‐(2‐CHLOROETHYL)IMIDAZO(5,1‐D)‐1,2,3,5‐TETRAZIN‐4(3H)‐ONE, A NOVEL BROAD‐SPECTRUM ANTITUMOR AGENT (1984)

Abstract Das Diazoimidazol (1) reagiert mit Isocyanaten (II) zu Imidazotetrazinonen (111), von denen das Chlorethylderivat mit Alkoholen unter Bildung der Verbindungen (IV)‐(VI) gespalten wird.
Multiobjective Optimal Design of MEMS-Based Reconfigurable and Evolvable Sensor Networks for Space Applications (2007)

In this paper, the multiobjective optimal design of space-based reconfigurable sensor networks with novel adaptive MEMS antennas is investigated by using multiobjective evolutionary algorithms. The non-dominated sorting genetic algorithm II (NSGA-II) is employed to obtain multi-criteria Pareto-optimal solutions, which allows system designers to easily make a reasonable trade-off choice from the set of non-dominated solutions according to their preferences and system requirements. As a case study, a cluster-based satellite sensing network is simulated under multiple objectives. Most importantly, this paper also presents the application of our newly designed adaptive MEMS antennas together with the NSGA-II to the multiobjective optimal design of space-based reconfigurable sensor networks.
Esterolytic activities of Enterococcus durans and Enterococcus faecium strains isolated from Greek cheese (1993)

The work describes the spectrometric and electrophoretic detection of esterolytic activities in cell-free extracts of 6 E.durans and 6 E.faecium strains isolated from Greek cheese
ChemInform Abstract: FULVENES WITH INVERSE RING POLARIZATION. 15. (8 + 2) CYCLOADDITION OF ELECTRON‐RICH HEPTAFULVENES: RANGE OF APPLICATION AND STEREOCHEMISTRY (1985)

Abstract Fulvene mit inverser Ringpolarisation.
NA-23 Longitudinal and Transverse Relaxation Studies of Counterion Binding to Poly(ethylene-Maleic Anhydride) (1995)

JMOs and medical students do not show high levels of confidence in basic ophthalmological clinical skills and knowledge, and report inadequate emphasis on ophthalmology during medical school.
Algorithmes de prise en charge de la maladie de Crohn en 2016 : Consensus National Français (2016)

La maladie de Crohn (MC) est une maladie inflammatoire chronique intestinale evoluant par poussees alternant avec des phases de remission. Il n’existe pas de traitement medical curatif de la MC, mais les traitements actuels permettent de plus en plus souvent d’obtenir un controle durable de la maladie et une amelioration de la qualite de vie des malades. Des complications digestives et extradigestives restent toutefois possibles. L’European Crohn's and Colitis Organisation (ECCO) a emis en 2010 des recommandations portant sur la definition, le diagnostic et la prise en charge de la MC. Afin d’aider les cliniciens dans la prise de decision therapeutique, un groupe de 59 gastro-enterologues francais ayant une experience dans la prise en charge de la MC s’est reuni pour elaborer, sur la base de ces recommandations, des algorithmes simples et pratiques. Cet avis d’experts professionnel a ete realise selon la methodologie de consensus formalise de type Groupe Nominal. Neuf situations cliniques ont ete discutees : MC legere active ; MC active non compliquee, de forme moderee avec et sans facteur de mauvais pronostic ; MC active non compliquee, de forme severe ; MC ano-perineale avec fistule unique, active ; MC ano-perineale avec fistule complexe avec ou sans abces ; MC compliquee avec abces ; MC avec stenose intestinale ; MC post-chirurgie. Deux groupes de travail ont ete constitues et des propositions d’algorithmes ont ensuite ete approuvees par l’ensemble du Groupe Nominal. Ces algorithmes representent le consensus pragmatique du groupe d’experts sur les modalites de la prise en charge therapeutique dans ces differentes situations cliniques. Ils seront disponibles via une webapplication : www.algorithmici.com
SURFACE FREE ENERGY MEASUREMENT OF AGGREGATES AND ITS APPLICATION TO ADHESION AND MOISTURE DAMAGE OF ASPHALT-AGGREGATE SYSTEMS (2001)

A protocol for measuring the thermodynamic surface free energy of aggregates using the Universal Sorption Devices is presented. Surface free energy, which is the reflection of material surface physical chemistry characteristics, can be used to evaluate adhesive fracture and moisture damage characteristics within the asphalt-aggregate system. Three widely used aggregates were tested using the Universal Sorption Device. The materials possessed very different surface free energies. By knowing the surface energy of the asphalt and aggregates, the most compatible asphalt-aggregate combination can be selected that will increase the ability of the asphalt pavement to resist adhesive fatigue fracture and moisture damage and maximize fracture healing.
Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium (2015)

Manganese (Mn) may foster aggregation of alpha-synuclein (αSyn) contributing to the pathogenesis of PD. Here, we examined the influence of αSyn overexpression on distribution and oxidation states of Mn in frozen-hydrated primary midbrain neurons (PMNs) by synchrotron-based X-ray fluorescence (XRF) and X-ray absorption near edge structure spectroscopy (XANES). Overexpression of αSyn increased intracellular Mn levels, whereas levels of Ca, Zn, K, P, and S were significantly decreased. Mn oxidation states were not altered. A strong correlation between Cu-/Mn-levels as well as Fe-/Mn-levels was observed in αSyn-overexpressing cells. Subcellular resolution revealed a punctate or filament-like perinuclear and neuritic distribution of Mn, which resembled the expression of DMT1 and MnSOD. While overexpression of αSyn did not significantly alter the expression patterns of the most-expressed Mn transport proteins (DMT1, VGCC, Fpn1), it attenuated the Mn release from Mn-treated neurons. Thus, these data suggest that αSyn may act as an intracellular Mn store. In total, neurotoxicity in PD could be mediated via regulation of transition metal levels and the metal-binding capacity of αSyn, which could represent a promising therapeutic target for this neurodegenerative disorder.
Dendritic cell immunotherapy in a neuroendocrine pancreas carcinoma (2001)

Our data indicate that vaccination with tumour lysate-pulsed DCs induced a significant antitumour immune response in a neuroendocrine carcinoma of the pancreas. This approach represents an alternative strategy for the treatment of advanced neuroendocrine carcinomas that are resistant to conventional therapy.