gebhart/patrepeval huggingface dataset:
FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior (2012)

FGF-10 and its receptors, FGFR1 and FGFR2, have been implicated in breast cancer susceptibility and progression, suggesting that fibroblast growth factor (FGF) signaling may be co-opted by breast cancer cells. We identify a novel pathway downstream of FGFR1 activation, whereby the receptor is cleaved and traffics to the nucleus, where it can regulate specific target genes. We confirm Granzyme B (GrB) as the protease responsible for cleavage and show that blocking GrB activity stopped FGFR1 trafficking to the nucleus and abrogates the promigratory effect of FGF stimulation. We confirm the in vivo relevance of our findings, showing that FGFR1 localized to the nucleus specifically in invading cells in both clinical material and a three-dimensional model of breast cancer. We identify target genes for FGFR1, which exert significant effects on cell migration and may represent an invasive signature. Our experiments identify a novel mechanism by which FGF signaling can regulate cancer cell behavior and provide a novel therapeutic target for treatment of invasive breast cancer.
Analysis of Life-Cycle Maintenance Strategies for Concrete Bridge Decks (2004)

This paper presents the development of a project-level decision support tool for ranking maintenance scenarios for concrete bridge decks deteriorated as a result of chloride-induced corrosion. The approach is based on a mechanistic deterioration model and a probabilistic life-cycle cost analysis. The analysis includes agency and user costs of alternative maintenance scenarios and considers uncertainties in the agency cost and the corrosion rate in the deterioration model. The tool presented in this paper can be used to find the optimal condition index of a given bridge deck that minimizes life-cycle cost. Based on the results obtained on three existing bridge decks, it is shown that the total life-cycle cost (user cost plus agency cost) is a nonlinear function of the maximum tolerable condition of the deck, Sm, and that for a practical range of Sm, the relationship between total life-cycle cost and Sm is convex.
Role of Magic-Sized Clusters in the Synthesis of CdSe Nanorods (2010)

The dynamics of the CdSe nanorod synthesis reaction have been studied, giving attention to the kinetics of magic-sized clusters (MSCs) that form as intermediates in the overall reaction. The MSCs have a distinct absorption peak, and the kinetics of this peak give insight into the overall reaction mechanism. In these studies, the reaction mixture consists primarily of Cd(phosphonate)(2) and trioctyl phosphine selenium in a solution of trioctylphosphine (TOP) and trioctylphosphine oxide (TOPO). We find that the rate at which precursors react to form CdSe monomers and the rates at which monomers react to form nanoparticles can be varied by changing the chemistry of the reaction mixture. Decreasing the TOP concentration decreases the extent to which selenium is bound, both in the precursors and on the particles' surfaces, and thereby increases both the precursor to monomer and monomer to particle reaction rates. Decreasing the phosphonate concentration decreases the extent to which phosphonate binds cadmium in the precursors and on the surface of the nanoparticles, also increasing the rates of both reactions. This is also accomplished by the addition of inorganic acids which protonate the phosphonates. The presence of inorganic acids (impurities) is the primary reason that the overall synthesis reaction is faster in solutions made with technical grade rather than purified TOPO. The TOP and phosphonic acid concentrations are coupled because excess phosphonic acids react with TOP, forming TOPO and less strongly binding species, specifically phosphinic acids, phosphine oxides, and phosphines.
Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells (2007)

Dietary phytochemicals exhibit chemopreventive potential in vivo through persistent low-dose exposures, whereas mechanistic in vitro studies with these agents generally use a high-dose single treatment. Because the latter approach is not representative of an in vivo steady state, we investigated antitumor activity of curcumin, 3,3'-diindolylmethane (DIM), epigallocatechin gallate (EGCG), genistein, or indole-3-carbinol (I3C) in breast cancer MDA-MB-231 cells, exposed in long-term culture to low concentrations, achievable in vivo. Curcumin and EGCG increased cell doubling time. Curcumin, EGCG, and I3C inhibited clonogenic growth by 55% to 60% and induced 1.5- to 2-fold higher levels of the basal caspase-3/7 activity. No changes in expression of cell cycle-related proteins or survivin were found; however, I3C reduced epidermal growth factor receptor expression, contributing to apoptosis. Because some phytochemicals are shown to inhibit DNA and histone modification, modulation of expression by the agents in a set of genes (cadherin-11, p21Cip1, urokinase-type plasminogen activator, and interleukin-6) was compared with changes induced by inhibitors of DNA methylation or histone deacetylation. The phytochemicals modified protein and/or RNA expression of these genes, with EGCG eliciting the least and DIM the most changes in gene expression. DIM and curcumin decreased cadherin-11 and increased urokinase-type plasminogen activator levels correlated with increased cell motility. Curcumin, DIM, EGCG, and genistein reduced cell sensitivity to radiation-induced DNA damage without affecting DNA repair. This model has revealed that apoptosis and not arrest is likely to be responsible for growth inhibition. It also implicated new molecular targets and activities of the agents under conditions relevant to human exposure.
A Novel Lightweight Low-Power Dual-Beam Ozone Photometer Utilizing Solid-State Optoelectronics (2009)

Abstract Recent advances in semiconductor materials and fabrication techniques have allowed the development of light-emitting diodes (LEDs) with wavelengths extending down into the UV-C region (λ &lt; 280 nm). A new ozone photometer has been developed utilizing these novel light sources. The application of solid-state technology to the proven dual-beam UV absorption technique has improved instrument performance while reducing power consumption and weight compared to existing instrumentation. The newly developed instrument is expected to have an accuracy of 1% at surface level pressure, a resolution better than 1 ppb, and measurement rates up to 1 Hz over the range of ozone mixing ratios encountered from the earth’s surface to the middle stratosphere. Size, weight, and power consumption have also been significantly reduced, with a mass of 3 kg and a power consumption of less than 5 W. Initial development is focused on an instrument suitable for measurements from autonomous platforms and in harsh environments; however, the technology is highly adaptable to other applications.
BPR in support of electronic commerce: a case study (2002)

Inter-organisational Electronic Commerce (E-Comm) applications have become an increasingly common vehicle for facilitating communication and information exchange between firms. However, the decision for business process change to support a shared process infrastructure between partners may have unforeseen consequences. It should therefore be taken only after careful consideration of possible implications and pitfalls. In this paper we present a real-life case study of E-Comm investment evaluation, where computer-based models of the business processes to be supported by E-Comm applications were developed. The models were then dynamically simulated to assist the companies involved in gaining insight on the real benefits and dangers associated with the planned business change. Drawing on the results of the case study, we discuss the potential of Business Process Modelling and Simulation to support assessment of E-Comm business value.
The Age of the Information Broker: An Introduction (2019)

Throughout the ages, man has recorded events, ideas, research and knowledge for the benefit of future generations. This information has been historically housed and preserved by various entities such as libraries, universities, government agencies and archives. In addition to preservation, one of the primary objectives of these various custodial entities was to provide easy access to the information. The amount of printed material during the explosion of the Information Age alone exceeded mankind’s complete history of documents. Due to the increased volume of data, the difficulty of accessing it and the growing demand for instant information, man’s ingenuity transformed the concept of extracting information. A need for assisting the present generation in finding specific information was evident; information became a commodity rather than a benefactor; and the information broker was spawned.
Wavefront Compensation With Pseudoconjugation (1982)

We discuss how novel arrangements of conventional (static/linear) optical elements can compensate for many classes of time-varying phase distortions in optical trains. Precision corner arrays, lens arrays, and K-mirror arrays are all applicable as pseudoconjugation elements in certain classes of problems. In some cases multipassing (four or more passes) of a distorting medium can offer improved performance. Although the compensation is more limited than that available from nonlinear optical phase conjugation (NOPC), problems associated with thresholds, pumps, and frequency translations are eliminated.
A procedure for the detection and removal of cloud shadow from AVHRR data over land (1998)

Although the accurate detection of cloud shadow in AVHRR scenes is important for many atmospheric and terrestrial applications, relatively little work in this area has appeared in the literature. This paper presents a new multispectral algorithm for cloud shadow detection and removal in daytime AVHRR scenes over land. It uses a combination of geometric and optical constraints, derived from the pixel-by-pixel cross-track geometry of the scene and image analysis methods to detect cloud shadow. The procedure works well in tropical and midlatitude regions under varying atmospheric conditions (wet-dry) and with different types of terrain. Results also show that underdetected cloud shadow ran produce errors of 30-40% in observed reflectances for affected pixels. Moreover, radiative transfer calculations show that the effects of cloud shadow are comparable to or exceed those of aerosol contamination for affected pixels. The procedure is computationally efficient and hence could be used to produce improved weather forecast, land cover, and land analysis products. The method is not intended for use under conditions of poor solar illumination and/or poor viewing geometry.
Radiocarbon Chronology of Late Pleistocene Deposits in Northwest Washington (1966)

Fourteen radiocarbon dates of shells and wood from late Pleistocene sediments in northwest Washington provide evidence for correlation of the Everson interstadial with the Two Creeks interval of the midcontinent and suggest possible correlations between the Sumas and Valders stadials and between the Vashon stadial and part of the Tazewell-Cary advances.
Eléments transposables et évolution des génomes (1997)

Les elements transposables sont des sequences moyennement a hautement repetees dans les genomes procaryotes et eucaryotes. Ils ont la particularite d'etre mobiles et donc de transposer au sein de ces genomes. Plusieurs classes d'elements transposables ont ete decrites en fonction de leurs modes de transposition. Les elements de classe I, regroupant les retrotransposons, les elements de type Lines et Sines, se caracterisent par une transposition necessitant une phase ARN. Seuls les retrotransposons et les Lines sont capables de synthetiser la transcriptase inverse. Ils ne sont presents que chez les eucaryotes. Les elements de classe II transposent par l'intermediaire d'une molecule d'ADN a l'aide d'une enzyme appelee la transposase. Ils sont presents chez les bacteries et les eucaryotes. La capacite des elements transposables a transposer de locus a locus produit une variabilite importante du genome. La variabilite induite correspond a de nombreux changements affectant aussi bien l'organisation des genes que leur fonction. Les sequences ainsi mutees sont soumises au crible de la selection naturelle. Les elements transposables sont donc des facteurs importants de l'evolution des genomes. Enfin au plan des applications biotechnologiques, leurs proprietes d'integration dans le genome en font des vecteurs de choix dans la transgenose animale ou vegetale.
Time Resolution of Photomultiplier Systems (1965)

Results on the ability of a photomultiplier system to resolve time differences are presented in graphic form. The results are presented in parametric form and hence may be applied to a wide variety of scintillator-photomultiplier combinations, provided the system is reasonably approximated by the model used in this work. In addition to the usual effects included (scintillator lifetime, pulse shape, transit time spread), the model includes the effects of finite risetime in the scintillation process.
Getting Started in 3D with Maya (2012)

Deliver professional-level 3D content in no time with this comprehensive guide to 3D animation with Maya. With over 12 years of training experience, plus several award winning students under his belt, author Adam Watkins is the ideal mentor to get you up to speed with 3D in Maya. Using a structured and pragmatic approach Getting Started in 3D with Maya begins with basic theory of fundamental techniques, then builds on this knowledge using practical examples and projects to put your new skills to the test. Prepared so that you can learn in an organic fashion, each chapter builds on the knowledge gained in the previous chapter, showing you all the essentials of 3D in Maya, from modeling and UV layout, to texture creation, rigging animating and rendering. As you go from project to project you'll develop a strong arsenal of skills that combined will form a complete end to end process to creating complete projects in Maya. The accompanying website provides all the tools you need to develop your skills. Project files to accompany the practical examples used throughout the text, so you can work along with the examples. Additional textures and models will give you all the resources you need to start making your own projects in no time at all.
Accuracy assessment of satellite derived land - cover data : a review (1994)

Accuracy assessment of land-cover classifications derived from remote sensing data has been recognized as a valuable tool in judging the fitness of these data for a particular application. Recent research initiatives in the area of spatial data accuracy and integration of remote sensing data in geographic information systems have revived the discussion on accuracy assessment. This article aims at contributing to this discussion by means of a review based on a division into positional and thematic accuracy. An important observation is that there are a limited number of methods for assessing data accuracy. However, the applied definitions differ very much from author to author, especially in the assessment of thermatic accuracy. Accuracy assessment mostly yields one single measure such as root-mean-square error or proportion of pixels correctly classified. These single measures do not give sufficient information and they can be based on statistically or methodologically non-valid methods. Therefore, not a single measure but also the total process of assessing these measures should explicitly be reported.
Mobile Information Filtering (2009)

Information filtering techniques have been continuously developed to meet challenges arisen from new requirements of Information Society. These techniques gain even much more on importance in the facet of greater mobility of people. One of the most dynamic and compelling areas is the environment of wireless and mobile devices. Just recently, information filtering and retrieval have begun to take into consideration circumstances in which they are being used. As information needs of mobile users are highly dynamic, this points out the necessity of considering additional set of attributes describing user situation—context. This article presents an information filtering system for mobile users (mobileIF) being developed in the Department of Management Information Systems at The Pozna University of Economics. Architecture of the mobileIF is a result of research done in the field of contexts, their taxonomies and influence on information relevance in dynamic user’s environment. The paper shows our approach to contexts, discusses time perspective on filtering systems and finally, describes mobileIF architecture and basic data flow within it. At last, we present our current research in fields related to the mobileIF system.
ASEPTIC LOOSENING OF TOTAL HIP REPLACEMENT (1997)

Aseptic loosening is a major cause of failure of total hip arthroplasty. The adverse tissue response to prosthetic wear particles, with activation of cytokine and prostanoid production, contributes to bone loss around the implants. We have investigated the possibility that inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2) are expressed in macrophages in the pseudomembrane at the bone-implant interface, thereby contributing to the periprosthetic bone resorption. We also assessed whether peroxynitrite, a nitric oxide (NO)-derived oxidant associated with cellular injury, is generated in the membrane. Enzymatic activity of iNOS was measured using the arginine-citrulline assay technique and prostaglandin E 2 (PGE 2 ), as an indicator of COX-2 activity, was measured using an enzyme immunoassay. Cellular immunoreactivity for iNOS, nitrotyrosine (a marker of peroxynitrite-induced cellular injury) and COX-2 was assessed by quantitative peroxidase immunocytochemistry while immunofluorescence methods were used for subsequent co-localisation studies with CD68 + macrophages. The presence of calcium-independent iNOS activity and PGE 2 production was confirmed in the homogenized interface membrane. Immunocytochemistry showed that periprosthetic CD68 + wear-debris-laden macrophages were the most prominent cell type immunoreactive for iNOS, nitrotyrosine and COX-2. Other periprosthetic inflammatory and resident cell types were also found to immunolocalise nitrotyrosine thereby suggesting peroxynitrite-induced protein nitrosylation and cellular damage not only in NO-producing CD68 + macrophages, but also in their neighbouring cells. These data indicate that both iNOS and COX-2 are expressed by CD68 + macrophages in the interface membrane and peroxynitrite-induced cellular damage is evident in such tissue. If high-output NO and peroxynitrite generation were to cause macrophage cell death, this would result in the release of phagocytosed wear debris into the extracellular matrix. A detrimental cycle of events would then be established with further phagocytosis by newly-recruited inflammatory cells and subsequent NO, peroxynitrite and prostanoid synthesis. Since both NO and have been implicated in the induction and PGE 2 maintenance of chronic inflammation with resulting loss of bone, and peroxynitrite in the pathogenesis of disease states, they may be central to the pathogenesis of aseptic loosening.
Measuring the Flow Properties of Yield Stress Fluids (1992)

The field of fluid mechanics is rapidly advancing, driven by unprecedented volumes of data from experiments, field measurements, and large-scale simulations at multiple spatiotemporal scales. Machine learning (ML) offers a wealth of techniques to extract ...Read More
Towards a Continuous Feedback Loop for Service-Oriented Environments (2018)

Agile software engineering practices aim at unifying software development (Dev) and software operation (Ops) in order to quickly release new software and gather feedback on new features in the latest version. The feedback loop gets closed mostly after new releases are deployed to production. During development, engineers do not receive feedback whether their changes are still aligned with the requirements and the formalized concept. This increases the risk of removing implemented code and decreases productivity. In this paper, we propose a tool for closing the feedback loop after each continuous deployment stage i.e. development, test and production. The continuous feedback is provided via a dependency model that represents the current software architecture on early stages. Hereby, each deployment phase and final release are compared against each other in order to uncover inconsistencies in regard to the predefined requirements.
Contrast Enhancement of Cyanoacrylate-Developed Latent Fingerprints Using Biological Stains and Commercial Fabric Dyes (1992)

Abstract Cyanoacrylate-developed latent fingerprints may be difficult to see or photograph if they are on light-colored surfaces. Biological stains and Rit® fabric dyes were tested for their ability to stain cyanoacrylate-developed latent fingerprints. Methanolic solutions of gentian violet, safranin bluish stain, diamond fuchsin, methyl green, iodine green, and Janus green B were found to stain cyanoacrylate-developed fingerprints on polyethylene, porcelain, and aluminum beverage cans. Hot (60°C) aqueous solutions of seven different shades of Rit® fabric dyes were found to stain cyanoacrylate-developed latent fingerprints on polyethylene, porcelain, aluminum beverage cans, and Styrofoam cups. The latent fingerprints stained with safranin bluish stain were strongly fluorescent under 312 nm ultraviolet light; latent fingerprints stained with gentian violet and diamond fuchsin were weakly fluorescent.
Applying regression & correlation : a guide for students and researchers (2001)

PART ONE: I NEED TO DO REGRESSION ANALYSIS TOMORROW Building Models with Regression and Correlation More Than One Independent Variable Multiples Regression Categorical Independent Variables PART TWO: I NEED TO DO REGRESSION ANALYSIS NEXT WEEK Assumptions in Regression Analysis Issues in Regression Analysis PART THREE: I NEED TO KNOW MORE OF THE THINGS THAT REGRESSION CAN DO Nonlinear and Logistic Regression Moderator and Mediator Analysis Introducing Some Advanced Techniques Multilevel Modelling and Structural Equation Modelling
Cluster Computing White Paper (2000)

Cluster computing is not a new area of computing. It is, however, evident that there is a growing interest in its usage in all areas where applications have traditionally used parallel or distributed computing platforms. The growing interest has been fuelled in part by the availability of powerful microprocessors and high-speed networks as off-the-shelf commodity components as well as in part by the rapidly maturing software components available to support high performance and high availability applications. This White Paper has been broken down into eleven sections, each of which has been put together by academics and industrial researchers who are both experts in their fields and where willing to volunteer their time and effort to put together this White Paper. The status of this paper is draft and we are at the stage of publicizing its presence and making a Request For Comments (RFC).
A critique of the theory of p-n-p-n devices (1964)

A review of various papers dealing with p-n-p-n device characteristics shows essentially different interpretations of 1) the condition for switching and 2) the operating state defined by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\alpha_{p}+ \alpha_{N} = 1</tex> . The present paper attempts to show the relationship between these various papers and to clarify the conditions which exist at the switching point and holding point.