gebhart/patrepeval huggingface dataset:
An Xmnl RFLP detected with a probe for the CYP2E gene locus on chromosome 10 (1990)

Journal Article An Xmnl RFLP detected with a probe for the CYP2E gene locus on chromosome 10 Get access David P. Kelsell, David P. Kelsell Search for other works by this author on: Oxford Academic PubMed Google Scholar C.Roland Wolf, C.Roland Wolf 1ICRF Laboratory of Molecular Pharmacology and Drug Metabolism, University Department of Biochemistry, Hugh Robson Building, George SquareEdinburgh, EH8 9XD, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Nigel K. Spurr Nigel K. Spurr Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 10, 25 May 1990, Page 3111, https://doi.org/10.1093/nar/18.10.3111 Published: 25 May 1990
An Experimental Setup for Electromagnetic Stimulation of Geoenvironmental Applications (2011)

Cleaning contaminated soil/groundwater is important to federal and state agencies. Traditional contaminant removal methods are costly and impractical for large sites. Less disruptive remediation techniques (e.g., air sparging) are attractive but limited by the restriction of airflow in soil. The use of electromagnetic (EM) stimulation to expedite airflow, diffusion, and control air channel formation is investigated. The diffusion of an inert dye as the diffusive matter within water and the effect of EM waves on the diffusion are experimentally modeled. To study the effect on air sparging through saturated soil, a clear acrylic box filled with a water-saturated glass bead medium and air as the diffusive matter is used. The effects of the electric field on air channel formation in the second case (i.e., glass-bead medium) are studied. It is expected that the stimulation of the water increases the diffusion of air between air channels and expands the air channel volume. The EM field is made possible using a dipole antenna connected to an RF source. The alternating electric field emitted off the antenna into the medium, oscillates the dipole water molecules. The stimulation helps enhance diffusion and enlarge the formed air channels.
Spectral Dispersion of Modulated Signals Due to Oscillator Phase Instability: White and Random Walk Phase Model (1983)

This paper considers the modeling of oscillator phase instability and the resulting spectral dispersion. A phase covariance matrix method is developed for determining the autocorrelation function and the power spectral density of the oscillator sinusoidal RF signal when corrupted by a superposition of a white phase random process and a random walk phase random process. By limiting the discussion to phase covariance matrices, it is shown that the direct use of a certain class of nonstationary phase random processes leads to stationary RF signal autocorrelation functions and associated power spectral densities. This is so despite the nonstationary phase driving force. The procedures provided here are also applied towards the determination of the average autocorrelation function and the average spectrum when the cisoidal oscillator signal undergoes modulation. Modulating waveforms used as examples include the CW, the infinite pulse train, and the finite pulse train.
<i>CHLAMYDOMONAS</i> FLAGELLA (1972)

Quantitative ultrastructural analysis and quantitative gel electrophoresis of preparations of selectively solubilized Chlamydomonas outer doublets indicated that tubulins 1 and 2 were present in both the A tubule and the B tubule, and that only tubulin 1 was present in the three protofilaments which form the wall ("partition") between the lumens of the A and B tubules. The data suggested that the remaining protofilaments of the outer doublet were grouped together in pairs containing the same type of tubulin, pairs containing tubulin 1 alternating with pairs containing tubulin 2. These findings were used to construct models for the arrangement of the two tubulins in the outer doublet. Further analysis by isoelectric focusing resolved tubulins 1 and 2 into at least five bands.
New Photorefractive Ferroelectric Material for Red and NearInfraRed: Tin Hypothiodiphosphate (1996)

New photorefractive crystal is described which can be easily sensitized to near infrared radiation by pre-illumination to incoherent white light with moderate intensity. The gain factor up to 7 cm -1 and the response time down to 10 ms are measured for unexpanded beams of CW radiation of a 1.06 µm Nd 3+ :YAG laser with 0.5 W output power.
Evolution of Chemical Diversity in Echinocandin Lipopeptide Antifungal Metabolites (2015)

The echinocandins are a class of antifungal drugs that includes caspofungin, micafungin, and anidulafungin. Gene clusters encoding most of the structural complexity of the echinocandins provided a framework for hypotheses about the evolutionary history and chemical logic of echinocandin biosynthesis. Gene orthologs among echinocandin-producing fungi were identified. Pathway genes, including the nonribosomal peptide synthetases (NRPSs), were analyzed phylogenetically to address the hypothesis that these pathways represent descent from a common ancestor. The clusters share cooperative gene contents and linkages among the different strains. Individual pathway genes analyzed in the context of similar genes formed unique echinocandin-exclusive phylogenetic lineages. The echinocandin NRPSs, along with the NRPS from the inp gene cluster in Aspergillus nidulans and its orthologs, comprise a novel lineage among fungal NRPSs. NRPS adenylation domains from different species exhibited a one-to-one correspondence between modules and amino acid specificity that is consistent with models of tandem duplication and subfunctionalization. Pathway gene trees and Ascomycota phylogenies are congruent and consistent with the hypothesis that the echinocandin gene clusters have a common origin. The disjunct Eurotiomycete-Leotiomycete distribution appears to be consistent with a scenario of vertical descent accompanied by incomplete lineage sorting and loss of the clusters from most lineages of the Ascomycota. We present evidence for a single evolutionary origin of the echinocandin family of gene clusters and a progression of structural diversification in two fungal classes that diverged approximately 290 to 390 million years ago. Lineage-specific gene cluster evolution driven by selection of new chemotypes contributed to diversification of the molecular functionalities.
Mass Measurements Reveal Preferential Sorption of Mixed Solvent Components in Porous Nanoparticles (2018)

The interplay of physical and chemical properties at the nanometer scale provides porous nanoparticles with unique sorption and interaction capabilities. These properties have aroused great interest toward this class of materials for application ranging from chemical and biological sensing to separation and drug delivery. However, so far the preferential uptake of different components of mixed solvents by porous nanoparticles is not measured due to a lack of methods capable of detecting the resulting change in physical properties. Here, a new method, nanomechanical mass correlation spectroscopy, is used to reveal an unexpected dependence of the effective mass density of porous metal-organic framework (MOF) nanoparticles on the chemistry of the solvent system and on the chemical functionalization of the MOF's internal surface. Interestingly, the pore size of the nanoparticles is much too large for the exclusion of small solvent molecules by steric hindrance. The variation of effective density of the nanoparticles with the solvent composition indicates that a complex solvent environment can form within or around the nanoparticles, which may substantially differ from the solvent composition.
Burnup calculations in square lattice cell (1980)

The relation between diet patterns and cardiovascular risk is well-established and sex differences in diet patterns likely differentially affect CVD risk between men and women.
Channeling of MeV<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant="normal">He</mml:mi></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>Ions in Tungsten and Other Crystals: An Intercomparison of Rutherford Scattering and of Characteristic<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>L</mml:mi></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>M</mml:mi></mml:math>X-Ray Yields (1969)

Measurements of wide-angle (150\ifmmode^\circ\else\textdegree\fi{}) scattering and of $L$ and $M$ x-ray yields in tungsten single crystals are reported as a function of crystallographic orientation with respect to an incident beam of 1.4-MeV helium ions. Comparison of these yields establishes both lower and upper limits for the minimum impact parameter (${r}_{min}$) between a channeled ion and the tungsten-lattice atoms; these limits are consistent with Lindhard's estimate that ${r}_{min}\ensuremath{\sim}\mathrm{a}$, the Thomas-Fermi screening distance (i.e.,\ensuremath{\sim}0.11 \AA{} for He in W). A similar comparison between wide-angle scattering and x-ray yield curves is reported for several other lattices---Al, Si, GaP, GaSb, and U${\mathrm{O}}_{2}$; again the results are consistent with the predicted relationship: ${r}_{min}\ensuremath{\sim}\mathrm{a}$. Anomalies in published orientation studies of $K$, $L$, and $M$ x-ray yields are shown to be due to depth effects.
Water‐suppressed volume‐selected <sup>1</sup>H NMR spectroscopy in viva: Application to study tumor metabolism (1987)

Volume selection using SPACE has been combined with water suppression techniques to provide high-resolution 1H NMR spectra from aqueous solutions. The technique developed was used to obtain spectra from a tumor growing on the hind leg of a rat. Water suppression factors of between 1000 and 2000 were achieved simultaneously with excellent volume selection.
Long-Term Patterns in CD4 Response Are Determined by an Interaction Between Baseline CD4 Cell Count, Viral Load, and Time: The Asia Pacific HIV Observational Database (APHOD) (2009)

Our analysis suggest that the long-term shape of post-cART CD4 cell count changes depends only on a 3-way interaction between baseline CD4 cell count, viral load response, and time.
Papillomavirus polypeptides E6 and E7 are zinc-binding proteins (1989)

Papillomavirus proteins E6 and E7 have Cys-X-X-Cys repeats which have been suggested to mediate zinc binding. We have developed a modification of an assay that detects zinc binding to proteins immobilized on filters. Using well-characterized metalloproteins, we show that, under reducing conditions, this assay distinguishes proteins that coordinate zinc through cysteine residues from those that bind the metal through other amino acids. Under these conditions, E6 and E7 polypeptides of human papillomavirus type 18 and bovine papillomavirus type 1 exhibited high-affinity zinc binding. Our results suggest that E6 and E7 are metalloproteins and may coordinate the metal ions through cysteine residues.
Application-specific language-oriented modularity: a case study of the ovirt project (2016)

Despite the availability of general purpose aspect languages (GPALs) and the availability of frameworks for creating domain specific aspect languages (DSALs), tangled and scattered code still prevails in modern software projects. Through the prism of a case study of the oVirt open source project we examine the conjecture that it may simply be too costly to implement crosscutting concerns in today's GPALs and DSALs. We introduce a subcategory of DSALs, called application specific aspect languages (ASALs), that along with a programming methodology, called language oriented modularity (LOM), allows such concerns to be modularized in a cost-effective, practical way. We illustrate this process concretely for the oVirt project.
Tikhonov regularization for electrical impedance tomography on unbounded domains (2003)

The mathematical analysis of geoelectric applications leads to the inverse problem of electric impedance tomography on unbounded domains. We introduce appropriate function spaces for this setting and discuss the analytic properties of the related forward operator on unbounded domains with Lipschitz boundaries. For the numerical approximation we consider Tikhonov regularization for a finite number of measurements. The main theorem states that this yields an approximation process which converges with an optimal rate to a minimum norm solution. Finally, numerical results in two and three dimensions, which are obtained from simulated, noisy data, confirm the theoretical findings.
Interference and collective behavior in atomic fluorescence (1993)

The study of collective atomic behavior is an important problem which has attracted much interest in recent years. Motivated by recent advances in ion trapping technology, 1 and by a calculation of interference in the fluorescence from two atoms, 2 we have investigated the effects of collective behavior on the interference fringe visibility. Interference in the fluorescence from two atoms separated by a fixed distance is examined as a function of driving laser and cavity parameters. The fringe visibility, a measure of the coherence of the atomic radiation, is calculated for the system of two driven atoms and the cavity mode. In free space, as the atoms are driven towards saturation, the visibility drops due to loss of coherence. The visibility goes from unity, at weak field, to 10% at saturation and falls off to zero asymptotically at higher fields. Dramatic improvement in visibility is found in the presence of the atom-cavity coupling, with the largest enhancement at intermediate driving field. This result indicates that induced coherence is a sensitive measure of collective behavior. Our progress in the experimental realization of this system with laser cooled beryllium ions confined in a linear trap is described, and directions for future work are indicated.
The Roman Feast : Waltzes (1905)

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Neuropeptide Y Attenuates Stress-Induced Bone Loss Through Suppression of Noradrenaline Circuits (2014)

Chronic stress and depression have adverse consequences on many organ systems, including the skeleton, but the mechanisms underlying stress-induced bone loss remain unclear. Here we demonstrate that neuropeptide Y (NPY), centrally and peripherally, plays a critical role in protecting against stress-induced bone loss. Mice lacking the anxiolytic factor NPY exhibit more anxious behavior and elevated corticosterone levels. Additionally, following a 6-week restraint, or cold-stress protocol, Npy-null mice exhibit three-fold greater bone loss compared to wild-type mice, owing to suppression of osteoblast activity. This stress-protective NPY pathway acts specifically through Y2 receptors. Centrally, Y2 receptors suppress corticotropin-releasing factor expression and inhibit activation of noradrenergic neurons in the paraventricular nucleus. In the periphery, they act to control noradrenaline release from sympathetic neurons. Specific deletion of arcuate Y2 receptors recapitulates the Npy-null stress response, coincident with elevated serum noradrenaline. Importantly, specific reintroduction of NPY solely in noradrenergic neurons of otherwise Npy-null mice blocks the increase in circulating noradrenaline and the stress-induced bone loss. Thus, NPY protects against excessive stress-induced bone loss, through Y2 receptor-mediated modulation of central and peripheral noradrenergic neurons.
Hyperglycemic Activity of Some Non-Nitrosated Streptozotocin Analogs (1976)

Six non-nitrosated and three nitrosated analogs of the antitumor and diabetogenic agent, streptozotocin, have been found to produce hyperglycemia in fasted rats. The hyperglycemia produced by the non-nitrostaed analogs was of early onset and did not result in the production of permanent diabetes. The data emphasizes the important role of the nitroso group of streptozotocin in the production of the hypoglycemic and permanent diabetic phases while the sugar moiety may have a direct influence on production of the early hyperglycemia phase.
SHORT COMMUNICATION: Regulated expression of <i>APE</i> apurinic endonuclease mRNA during wound healing in porcine epidermis (1996)

Abasic (AP) sites in DNA are cytotoxic and mutagenic and their repair is initiated by AP endonucleases. The major AP endonuclease of mammalian cells is encoded by the APE gene. Ape protein has also been proposed to modulate the activity of some transcription factors independently of its AP endonuclease activity. We investigated whether APE expression is coordinated with cell division, which could diminish mutagenesis. The level of APE mRNA was followed during wound healing in porcine epidermis, in which surgical wounding prompts rapid cell proliferation followed by a differentiation program to regenerate normal skin. In situ hybridization with a probe from human APE cDNA revealed strongly decreased expression in rapidly proliferating migrating cells during the first 1-3 days following wounding, succeeded by sharply increased APE expression that exceeded the pre-wounding levels by days 9-17. These changes were not observed in the surrounding undamaged tissue. In contrast to the foregoing in vivo results, APE expression in cultured primary human fibroblasts (IMR90) or myeloid leukemia cells (K562) was not coordinated with cell division. This biphasic APE expression during wound healing could relate to transcription factor regulation or it could allow unhindered DNA synthesis or prepare the developing epidermis to handle DNA damage. However, if transient under-expression of APE-encoded repair enzyme does occur, it might render regenerating skin especially vulnerable to mutagenesis during the cell proliferation phase.
Enhanced user-dependent recognition of Arabic Sign language via disparity images (2010)

This paper presents an enhanced solution for user-dependent recognition of isolated Arabic Sign language gestures using disparity images. The sequences of disparity images are used to segment out the body of the user from a non-stationary background in the video based gestures. The spatio-temporal features in the sequence of images are represented in two images by accumulating the prediction errors of consecutive segmented images according to the directionality of motion. Moreover, different accumulation weights are applied to distinguish the directionality of motion in each of the resultant images. The body of the user is segmented out in the disparity images by using K-means clustering to encapsulate the closest entity to the camera. The prediction errors accumulated in the two images are then transformed into the frequency domain using Discrete Cosine Transformation (DCT). Zonal coding is employed to form feature vectors from the DCT coefficients. Simple classification techniques such as Knn and linear discriminate functions are used identify the gestures based on the described procedure. Assessment of methodology is performed by collecting 50 repetitions of 23 gestures from four different users using Bumblebee XB3 camera. A classification rate of 96.8%, and an improvement of 62% are reported for the described methodology compared with accumulating the prediction errors without segmenting the body of the user.
Room dimensions for optimum listening and the half-room principle (1958)

This paper discusses the relation of room dimensions and speaker placement to the quality of low-frequency sound reproduction. Dimensional ratios for home music rooms are suggested.
Penetration of transverse magnetic field in a stack of laminations and induced voltages (2012)

This paper aims at providing an accurate description and explanation of the behavior of the magnetic flux when it incomes in the transversal (unusual) direction to the magnetic sheets, as it appears in the front end zone of large turbogenerator cores. Several experiments on a basic apparatus have been carried out, monitoring fluxes in 2 directions, and induced voltages between sheets. In order to explain the flux distribution within the magnetic sheets stack, a simulation based on a simple reluctance network has been used. Streszczenie. Artykul ma na celu otrzymanie dokladnego opisu I wyjaśnienia zachowania pola magnetycznego wnikającego w kierunku prostopadlym do blach magnetycznych na powierzchniach czolowych rdzenia duzego turbogeneratora. Kilka eksperymentow zostalo przeprowadzonych na podstawowej aparaturze, w ktorych monitorowano pole magnetyczne (dwa kierunki) oraz napiecie indukujące sie miedzy blachami. Dla wyjaśnienia rozkladu strumienia magnetycznego wewnątrz pakietu uwarstwionego przeprowadzone symulacją komputerową opartą na prostej sieci reluktancyjnej. (Penetracja normalnego pola magnetycznego w uwarstwiony pakiet i indukowane napiecia).
3606 Development of Micro Ejector for Butane Catalytic Combustor (2005)

A micro ejector for butane catalytic combustor is investigated. Quasi-1-D computation and CFD analysis are conducted to investigate the effect of various design parameters on ejector performances. A truly 3-D micro convergent-divergent nozzle having a throat diameter of 42μm is fabricateed by electro-discharge machining. It is shown in experimental evaluation of the present micro ejector that the volume flow rate of entrained air can reach 43 times the value of butane when the back pressure of ejector is set as 11.6 Pa.
<i>In vivo</i>studies on the metabolic derangement in a patient with D‐glyceric acidaemia and hyperglycinaemia (1983)

In a mentally retarded boy, who excreted elevated amounts of glycine, D-glyceric acid and acylglycines and whose cells exhibited diminished D-glycerate dehydrogenase and glycine cleavage activity, investigations have been undertaken aiming at characterizing the relationship between the different accumulations. This was done in vivo by trying in a specific manner to alter in turn the degree of accumulation of each of the three classes of compounds and then monitoring changes in the others. The results suggest, that the D-glyceric acid accumulation is directly caused by the genetic defect, since the D-glyceric acid excretion was not altered by changes in degree of accumulation of either glycine or acylglycines. Similarly alterations in acylglycine excretion caused alterations in glycine but not in D-glyceric acid excretion. Based on these findings a model for the pathogenesis behind the accumulations of acylglycines and glycine is proposed.
Technetium-99m-labeled liposomes to image experimental colitis in rabbits: comparison with technetium-99m-HMPAO-granulocytes and technetium-99m-HYNIC-IgG. (1998)

In this rabbit model, 99mTc-labeled granulocytes, IgG and liposomes all rapidly visualized colonic inflammation. Granulocytes and liposomes showed the highest CI. Technetium-99m-labeled PEG-liposomes may be an attractive alternative for labeled leukocytes to image inflammatory bowel disease, because they can be prepared off the shelf and no handling of blood is required.