gebhart/patrepeval huggingface dataset:
Workshop on Beam-Beam and Beam-Radiation Interactions : high intensity and nonlinear effects UCLA, May 13-16, 1991 (1992)

Review of symmetric disruption, K.Yokoya asymmetric disruption in linear colliders, J.Wurtele asymmetric disruption in circular colliders, K.Hirata asymmetric disruption in linear circular colliders, J.Boyce breakdown of QED vacuum and luminosity lifetime of heavy ion colliders, M.Rhoades-Brown merits of using heavy ions as probes of symmetry breaking at the SSC, C.Bottcher nonlinear QED effects in the interaction particle beams and EM radiation, K.McDonald gravitational effects from particles and photon beams, P.Chen gravitational effects from particle and photon beams - experimental possibilities, G.Diambrini Palazzi a tunable FM detector for gravitational waves, E.Picasso.
Heterogeneity of Igh‐linked allotypic determinants expressed on functional T cell subsets as detected by monoclonal antibodies (1984)

Abstract Hybridomas producing monoclonal antibodies (mAb) specific for immunoglobulin heavy chain (Igh) allotype‐linked gene products expressed only on functional T cells but not on B cells and macrophages were established by fusion of allotype congenic SJL (Igh‐1 b ) and SJA/9 (Igh‐1 a ) B cells immunized reciprocally with partner spleen cells with a myeloma P3‐X63‐Ag8‐653 of BALB/c origin. Nine mAb have been selected on the criteria that they can specifically block various antigen‐dependent functions of known T cell subsets in in vitro immune responses of mouse strains having the corresponding Igh allotype, but not the other one. These included (a) four mAb that augment the in vitro secondary antibody response of either Igh‐1 a or Igh‐1 b strains and thus are considered to react with the Igh‐linked allotypic determinant expressed on suppressor T cells, (b) one mAb that inhibits the helper T cell activity of Igh‐1 b but not of Igh‐1 a strains, (c) two mAb that inhibit the antigen‐induced pro‐liferative response of Igh‐1 a but not Igh‐1 b strains, and (d) two mAb that block the cytotoxicity of alloreactive cytotoxic T cells of Igh‐1 a strains. The linkage to Igh‐1 allotype of the T cell products was established by testing with Igh‐1‐congenic strains with different backgrounds including the H‐2 complex. Some of the mAb were able to react with cloned hybridomas and a continuous cell line of the given allotype and functions. Each mAb was able to block one of the known functions of T cell subsets, but not others, indicating the existence of the heterogeneity and multiplicity of the Igh allotype‐linked products on T cells.
Le frelon asiatique, serial killer d'abeilles (2015)

National audience
Effectiveness of Varicella Vaccination Program in Preventing Laboratory-Confirmed Cases in Children in Seoul, Korea (2016)

A universal one-dose varicella vaccination program was introduced in 2005 in Republic of Korea. However, the incidence of varicella in Korea has tripled over the last decade. We conducted a community based 1:1 matched case-control study to assess the effectiveness of one MAV strain-based vaccine and three Oka strain-based vaccines licensed for use in Korea. All cases were children in Seoul, Korea with varicella who were reported to the National Notifiable Disease Surveillance System in Seoul during 2013. The controls were age-matched children with mumps or scarlet fever but no history of varicella. We included 537 cases and 537 controls. The overall effectiveness of one dose of varicella vaccination was 13% (95% confidence interval [CI], -17.3-35.6). Of the four licensed varicella vaccines, only one was highly effective (88.9%; 95% CI, 52.1-97.4). The vaccine effectiveness for the other vaccines were 71.4% (95% CI, -37.5-94.1), -5% (95% CI, -61.9-31.9), and -100% (95% CI, -700-50.0). The overall effectiveness of vaccination was 75.8% (95% CI, 22.8-92.4) in the first year after vaccination and decreased thereafter; the effectiveness became -7.2% (95% CI, -130.9-59.2) in the fourth year after vaccination. Further studies are warranted to investigate reduced effectiveness of varicella vaccines in Korea.
Three-Dimensional Viscous Flow Analysis of an Advanced Ducted Propeller Subsonic Inlet (1995)

A time-marching Navier-Stokes code called PARC3D was used to study the three-dimensional viscous flow associated with an advanced ducted propeller (ADP) subsonic inlet at takeoff operating conditions. At a freestream Mach number of 0.2, experimental data of the ADP inlet model indicated that the flow on the cowl windward lip remained attached at an angle of attack of 25 cleg, became unstable at 29 deg, and separated at 30 deg. An experimental through-flow test study (without propeller) using another, but similar, inlet indicated that the separation occurred at an angle of attack a few degrees below the value observed when the inlet was tested with the propeller. This evidence showed that the propeller exerted a favorable effect on the inlet low speed and high angle-of-attack performance. A stationary blockage device was designed and tested with this latter inlet to simulate the propeller effect. The test data showed that the blockage device helped prevent the inlet flow from being separated at angle of attack a few degrees higher than the inlet through-flow, but was 1 deg lower than the inlet with the propeller. In the present numerical study, this flow blockage was modeled via a PARC3D computational boundary condition (BC) called the screen BC. The principle formulation of this BC was based on the one-and-half dimensions actuator disk theory. This screen BC was prescribed at the inlet propeller face station. Numerical results were obtained for inlet flow calculations with and without the screen BC. The results with the screen BC compared better with the ADP experimental test data than those obtained without the screen BC, particularly when the inlet flow separated.
Adaptive compression of animated sequences (2002)

Unsupervised artificial neural learning algorithms have clearly demonstrated their practical value for vector quantization of speech and stationary images. We examine competitive learning as an adaptive compression algorithm for highly repetitious video signals such as those found in animated cartoons. The characteristics of animated video are presented and their suitability for compression are examined. An artificial neural network system based on the soft competitive learning algorithm is presented for the adaptive compression of these video signals. Based on comparisons with existing compression techniques, this investigation indicates that a compression ratio of better than 100:1 is a reasonable expectation.
Hyperspectral imaging for astronomy and space surviellance (2004)

We present results of field evaluations of computed tomography imaging spectrometer (CTIS) systems, using an adaptive optics (AO) compensated telescope, for applications in astronomical multispectral imaging and imaging spectroscopy in both visible (0.4 - 0.7 μm) and near infrared (1.2 - 2.1 μm) bands. We develop and analyze a convolution model for this hyperspectral imaging method which includes a convolution representation of the effects of the AO system. We use expectation maximization, with additional prior constraints derived from the physics of the instrumental, statistical and atmospheric effects inherent in such observations, to extract details of features in the hyperspectral images. Data for this study were obtained using the Advanced Electro-Optics System (AEOS) -- a facility of the Air Force Maui Space Surviellance System.
Photochemical Oxidative Growth of Iridium Oxide Nanoparticles on CdSe@CdS Nanorods (2016)

We demonstrate a procedure for the photochemical oxidative growth of iridium oxide catalysts on the surface of seeded cadmium selenide-cadmium sulfide (CdSe@CdS) nanorod photocatalysts. Seeded rods are grown using a colloidal hot-injection method and then moved to an aqueous medium by ligand exchange. CdSe@CdS nanorods, an iridium precursor and other salts are mixed and illuminated. The deposition process is initiated by absorption of photons by the semiconductor particle, which results with formation of charge carriers that are used to promote redox reactions. To insure photochemical oxidative growth we used an electron scavenger. The photogenerated holes oxidize the iridium precursor, apparently in a mediated oxidative pathway. This results in the growth of high quality crystalline iridium oxide particles, ranging from 0.5 nm to about 3 nm, along the surface of the rod. Iridium oxide grown on CdSe@CdS heterostructures was studied by a variety of characterization methods, in order to evaluate its characteristics and quality. We explored means for control over particle size, crystallinity, deposition location on the CdS rod, and composition. Illumination time and excitation wavelength were found to be key parameters for such control. The influence of different growth conditions and the characterization of these heterostructures are described alongside a detailed description of their synthesis. Of significance is the fact that the addition of iridium oxide afforded the rods astounding photochemical stability under prolonged illumination in pure water (alleviating the requirement for hole scavengers).
Chromogranin A Induces the Biogenesis of Granules with Calcium- and Actin-Dependent Dynamics and Exocytosis in Constitutively Secreting Cells (2012)

Chromogranins are a family of acidic glycoproteins that play an active role in hormone and neuropeptide secretion through their crucial role in secretory granule biogenesis in neuroendocrine cells. However, the molecular mechanisms underlying their granulogenic activity are still not fully understood. Because we previously demonstrated that the expression of the major component of secretory granules, chromogranin A (CgA), is able to induce the formation of secretory granules in nonendocrine COS-7 cells, we decided to use this model to dissect the mechanisms triggered by CgA leading to the biogenesis and trafficking of such granules. Using quantitative live cell imaging, we first show that CgA-induced organelles exhibit a Ca(2+)-dependent trafficking, in contrast to native vesicle stomatitis virus G protein-containing constitutive vesicles. To identify the proteins that confer such properties to the newly formed granules, we developed CgA-stably-expressing COS-7 cells, purified their CgA-containing granules by subcellular fractionation, and analyzed the granule proteome by liquid chromatography-tandem mass spectrometry. This analysis revealed the association of several cytosolic proteins to the granule membrane, including GTPases, cytoskeleton-based molecular motors, and other proteins with actin- and/or Ca(2+)-binding properties. Furthermore, disruption of cytoskeleton affects not only the distribution and the transport but also the Ca(2+)-evoked exocytosis of the CgA-containing granules, indicating that these granules interact with microtubules and cortical actin for the regulated release of their content. These data demonstrate for the first time that the neuroendocrine factor CgA induces the recruitment of cytoskeleton-, GTP-, and Ca(2+)-binding proteins in constitutively secreting COS-7 cells to generate vesicles endowed with typical dynamics and exocytotic properties of neuroendocrine secretory granules.
Nitric oxide and nitrogen dioxide content of whole air samples obtained at altitudes from 12 to 30 km (1985)

Whole air samples were obtained in the stratosphere using a liquid helium‐cooled cryosampler mounted on a balloon platform. Approximately 1 g mol of sample was obtained at each of three altitudes per balloon flight and was maintained at 4 K until desorption just prior to analysis. Samples were obtained at six altitudes ranging from 12 to 30 km and at five latitudes from 9° to 64°N. Nitric oxide and the sum of nitric oxide and nitrogen dioxide content of the samples were determined using two chemiluminescence analyzers. Results from flights conducted between 1977 and 1981 are correlated with atmospheric motions and other significant variables and evaluated in terms of both one‐ and two‐dimensional models of the stratosphere.
<i>E(z)</i>: a polycomb group gene or a trithorax group gene? (1996)

The products of the Polycomb group of genes are cooperatively involved in repressing expression of homeotic selector genes outside of their appropriate anterior/posterior boundaries. Loss of maternal and/or zygotic function of Polycomb group genes results in the ectopic expression of both Antennapedia Complex and Bithorax Complex genes. The products of the trithorax group of genes are cooperatively involved in maintaining active expression of homeotic selector genes within their appropriate anterior/posterior boundaries. Loss of maternal and/or zygotic function of trithorax group genes results in reduced expression of both Antennapedia Complex and Bithorax Complex genes. Although Enhancer of zeste has been classified as a member of the Polycomb group, in this paper we show that Enhancer of zeste can also be classified as a member of the trithorax group. The requirement for Enhancer of zeste activity as either a trithorax group or Polycomb group gene depends on the homeotic selector gene locus as well as on spatial and temporal cues.
The First Stable Heteracyclopropabenzene:  Synthesis and Crystal Structure of a Silacyclopropabenzene (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe First Stable Heteracyclopropabenzene: Synthesis and Crystal Structure of a SilacyclopropabenzeneKen Hatano, Norihiro Tokitoh, Nozomi Takagi, and Shigeru NagaseView Author Information Institute for Fundamental Research of Organic Chemistry Kyushu University, 6-10-1 Hakozaki Higashi-ku, Fukuoka 812-8581, Japan Department of Chemistry, Graduate School of Science Tokyo Metropolitan University, Minamiosawa Hachioji, Tokyo 192-0397, Japan Cite this: J. Am. Chem. Soc. 2000, 122, 19, 4829–4830Publication Date (Web):April 29, 2000Publication History Received10 February 2000Published online29 April 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/ja000501khttps://doi.org/10.1021/ja000501krapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views521Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Crystallography,Energy,Hydrocarbons,Molecular structure Get e-Alerts
Les hexaborures de terres rares : le système bore-scandium (1972)

International audience
Stacking and Registry Effects in Layered Materials: The Case of Hexagonal Boron Nitride (2010)

The interlayer sliding energy landscape of hexagonal boron nitride (h-BN) is investigated via a van der Waals corrected density functional theory approach. It is found that the main role of the van der Waals forces is to anchor the layers at a fixed distance, whereas the electrostatic forces dictate the optimal stacking mode and the interlayer sliding energy. A nearly free-sliding path is identified, along which band gap modulations of ∼0.6 eV are obtained. We propose a simple geometric model that quantifies the registry matching between the layers and captures the essence of the corrugated h-BN interlayer energy landscape. The simplicity of this phenomenological model opens the way to the modeling of complex layered structures, such as carbon and boron nitride nanotubes.
Dual Postero‐Medial Portal Technique for Posterior Cruciate Ligament Tibial Avulsion Fracture Fixations (2021)

The posterior cruciate ligament surgery invariably demands adequate posterior compartment visualisation and instrumentation. The addition of posteromedial (PM) portal during posterior cruciate ligament (PCL) surgeries remains essential. The further addition of one more proximal posteromedial (PM) portal further enhances the instrumentation including suture passage in the substance of PCL or screws insertion and more so obviates the need for trans-septal and posterolateral (PL) portals. This additional PM portal is created in the safe zone under direct visualisation utilising outside-in technique and is spaced to prevent crowding of instrument with arthroscope. The proximal higher PM portal serves as instrument portal and provides optimal trajectory for even arthroscopic screw fixation of PCL avulsion fractures.
Fabrication of long microchannels with circular cross section using astigmatically shaped femtosecond laser pulses and chemical etching (2006)

We report on the fabrication of microfluidic channels in fused silica using femtosecond laser irradiation followed by chemical etching. Using an astigmatically shaped beam, we achieve microchannels with circular cross section and length up to 1.5mm. We use the same femtosecond laser, with different irradiation parameters, to fabricate high quality optical waveguides on the same substrate. The integration of microchannels and waveguides will enable a forthcoming class of biophotonic sensors.
The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine (2000)

Increased homocysteine levels are associated with various pathological conditions in humans, including stroke and cardiovascular disorders. Homocysteine acts as an excitatory amino acid in vivo and may influence the threshold of migraine headache. Frosst et al. [1995] reported an association between the homozygous C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and serum homocysteine levels. This study was designed to determine the prevalence of the MTHFR mutation in Japanese patients with migraine and tension-type headache (TH). Seventy-four patients with migraine headaches (22 with aura and 52 without aura), 47 with THs, and 261 normal controls were recruited. Genotyping of MTHFR C677T polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. We detected that the incidence of the homozygous transition (T/T) in migraine sufferers (20.3%) was significantly higher than that in controls (9.6%). Moreover, the frequency of the T/T genotype in individuals with migraine headaches with aura was remarkably high (40.9%). The MTHFR T allele was more frequent in the migraine group than in the control group. Our results support the conclusion that the MTHFR gene, causing mild hyperhomocysteinemia may be a genetic risk factor for migraine. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:762-764, 2000.
Transcriptional Repression by Binding of Poly(ADP-ribose) Polymerase to Promoter Sequences (2002)

Poly(ADP-ribose) polymerase (PARP) is a DNA-binding enzyme that plays roles in response to DNA damage, apoptosis, and genetic stability. Recent evidence has implicated PARP in transcription of eukaryotic genes. However, the existing paradigm tying PARP function to the presence of DNA strand breaks does not provide a mechanism by which it may be recruited to gene-regulating domains in the absence of DNA damage. Here we report that PARP can bind to the DNA secondary structures (hairpins) in heteroduplex DNA in a DNA end-independent fashion and that automodification of PARP in the presence of NAD+ inhibited its hairpin binding activity. Atomic force microscopic images show that in vitro PARP protein has a preference for the promoter region of the PARP gene in superhelical DNA where the dyad symmetry elements likely form hairpins according to DNase probing. Using a chromatin cross-linking and immunoprecipitation assay we show that PARP protein binds to the chromosomal PARP promoter in vivo. Reporter gene assays have revealed that the transcriptional activity of the PARP promoter is 4-5-fold greater in PARP knockout cells than in wild type fibroblasts. Reintroduction of vectors expressing full-length PARP protein or its truncated mutant (DNA-binding domain retained but lacking catalytic activity) into PARP(-/-) cells has conferred transcriptional down-regulation of the PARP gene promoter. These data provide support for PARP protein as a potent regulator of transcription including down-regulation of its own promoter.
Genomic deletion and promoter methylation status of Hypermethylated in Cancer 1 (HIC1) in mantle cell lymphoma (2008)

Mantle cell lymphomas (MCL), characterized by the t(11;14)(q13;q32), frequently carry secondary genetic alterations such as deletions in chromosome 17p involving the TP53 locus. Given that the association between TP53-deletions and concurrent mutations of the remaining allele is weak and based on our recent report that the Hypermethylated in Cancer 1 (HIC1) gene, that is located telomeric to the TP53 gene, may be targeted by deletions in 17p in diffuse large B-cell lymphoma (DLBCL), we investigated whether HIC1 inactivations might also occur in MCL. Monoallelic deletions of the TP53 locus were detected in 18 out of 59 MCL (31%), while overexpression of p53 protein occurred in only 8 out of 18 of these MCL (44%). In TP53-deleted MCL, the HIC1 gene locus was co-deleted in 11 out of 18 cases (61%). However, neither TP53 nor HIC1 deletions did affect survival of MCL patients. In most analyzed cases, no hypermethylation of the HIC1 exon 1A promoter was observed (17 out of 20, 85%). However, in MCL cell lines without HIC1-hypermethylation, the mRNA expression levels of HIC1 were nevertheless significantly reduced, when compared to reactive lymph node specimens, pointing to the occurrence of mechanisms other than epigenetic or genetic events for the inactivation of HIC1 in this entity.
<i>In Vitro</i>and<i>In Vivo</i>Effects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue (2015)

Metformin is applied not only as antidiabetic drug, but also in the treatment of obesity or as antiaging drug. The first part of the research discussed the effect of metformin at concentrations of 1 mM, 5 mM, and 10 mM on the morphology, ultrastructure, and proliferation potential of mice adipose-derived multipotent mesenchymal stromal cells (ASCs) in vitro. Additionally, we determined the influence of metformin on mice adipose tissue metabolism. This study has shown for the first time that metformin inhibits the proliferative potential of ASCs in vitro in a dose- and time-dependent manner. In addition, we have found a significant correlation between the activity of ASCs and osteopontin at the mRNA and protein level. Furthermore, we have demonstrated that 5 mM and 10 mM metformin have cytotoxic effect on ASCs, causing severe morphological, ultrastructural, and apoptotic changes. The reduced level of OPN in the adipose tissue of metformin-treated animals strongly correlated with the lower expression of Ki67 and CD105 and increased caspase-3. The metformin influenced also circulating levels of OPN, which is what was found with systemic and local action of metformin. The results are a valuable source of information regarding the in vitro effect of metformin on adipose-derived stem cells.