gebhart/patrepeval huggingface dataset:
Crystallization and preliminary X-ray analysis of a novel Kunitz-type kallikrein inhibitor from<i>Bauhinia bauhinioides</i> (2005)

A Kunitz-type protease inhibitor (BbKI) found in Bauhinia bauhinioides seeds has been overexpressed in Escherichia coli and crystallized at 293 K using PEG 4000 as the precipitant. X-ray diffraction data have been collected to 1.87 Å resolution using an in-house X-ray generator. The crystals of the recombinant protein (rBbKI) belong to the orthorhombic space group P212121, with unit-cell parameters a = 46.70, b = 64.14, c = 59.24 Å. Calculation of the Matthews coefficient suggests the presence of one monomer of rBbKI in the asymmetric unit, with a corresponding solvent content of 51% (VM = 2.5 Å3 Da−1). Iodinated crystals were prepared and a derivative data set was also collected at 2.1 Å resolution. Crystals soaked for a few seconds in a cryogenic solution containing 0.5 M NaI were found to be reasonably isomorphous to the native crystals. Furthermore, the presence of iodide anions could be confirmed in the NaI-derivatized crystal. Data sets from native and derivative crystals are being evaluated for use in crystal structure determination by means of the SIRAS (single isomorphous replacement with anomalous scattering) method.
ChemInform Abstract: Regioselective Carbonyl Insertion Reactions with α‐Substituted Heterocycles. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On land mobile satellite navigation performance degraded by multipath reception (2007)

In this paper simulation results of DLR's ultra-wideband land mobile satellite (LMS) multipath channel model are presented.The goal is the evaluation of GNSS performance in the rail environment.For this safety of life (SOL) application an urban railway was identified as the most critical scenario.The channel model is based on a measurement campaign of the land mobile multipath channel performed in 2002.From this data a model was derived that is synthesising the measured channel impulse response.It allows the realistic simulation of the multipath channel by approximating every single reflection.This model includes time variant reflectors approaching and receding in dependency of the azimuth and elevation of the satellite.All the signal processing had been realised independently of the transmitted signal.Therefore the usability for both, navigation systems GPS as well as GALILEO is given.
Investigation of percolation theory and permittivity model with one-dimensional fillers (2017)

In this report, a new permittivity model based on volume weighted average and probability has been used to explain and predict the dielectric permittivity of carbon nanotubes (CNTs)/polyimide (PI) hybrid materials. The model has been verified by a composite with 8.1 vol% fillers load. The calculative data (7.97 vol%) of percolation threshold, based on the intrinsic permittivity of fillers and matrix, fitted to the reported data (8.01 vol%) in the case of 100 Hz. A potential mechanism indicated that the permittivity of the composites is influenced by localized polarization of fillers and matrix. However, geometric connection and tunneling are dispensable to plasma resonance. Additionally, a derived formula of this model expresses that extremely high permittivity of composites can be intensively influenced by the permittivity of the matrix.
Regulation of glomerular TGF-beta expression in the contralateral kidney of two-kidney, one-clip hypertensive rats. (1998)

Previous studies have demonstrated that angiotensin II stimulates expression of transforming growth factor-beta (TGF-beta) in cultured renal cells. To investigate whether similar mechanisms are operative in vivo, glomerular TGF-beta mRNA expression was investigated in two-kidney, one-clip (2-K 1-C) hypertensive rats. Glomerular TGF-beta1 transcripts were elevated in the clipped kidney 6 d, but not 3 d, after surgery. Later, during the course of the disease (21 to 35 d), TGF-beta1 mRNA was upregulated in contralateral kidneys compared with sham-operated control kidneys. There was no difference in plasma TGF-beta1 levels between 2-K 1-C rats and controls. Treatment with the AT1 receptor antagonist losartan, as well as with triple therapy (hydralazine, reserpine, and hydrochlorothiazide), started 1 d after clipping, significantly reduced systolic BP in hypertensive rats at day 21 after clipping. Both treatments were equally effective in preventing the increase in glomerular TGF-beta1 mRNA and protein expression in the contralateral kidney at day 21. In a second set of experiments, interventional treatment with losartan or triple therapy, starting 14 d after surgery, was investigated. This treatment for 3 wk significantly reduced the increase in TGF-beta1 expression in the contralateral kidney. At day 35 after clipping, considerable glomerular damage and sclerosis were present, mainly in contralateral kidneys. Interventional treatment with losartan or triple therapy partly prevented this glomerular damage of the contralateral kidney. The data demonstrate that TGF-beta1 expression in the contralateral kidney in 2-K 1-C rats is regulated by the increase in systemic BP rather than by direct effects of angiotensin II.
A Sex Difference in the Seasonal Variation of Suicide Rate: A Single Cycle for Men, Two Cycles for Women (1981)

The marked seasonal fluctuation in suicide rates observed by Durkheim appears to be diminishing, and in some cases, to have vanished. In this study, suicide data in Britain from 1958 to 1974 were studied by auto-correlational methods. A cyclical variation was found for both men and women. Men showed a single twelve monthly cycle whereas women showed two cycles. No explanation for this difference is immediately apparent.
Putting PANTS on Linux: Transparent Migration in a Beowulf Cluster (2000)

PANTS is the PANTS Application Node Transparency System. It provides automatic and transparent load sharing on a Beowulf cluster of Linux computers. PANTS manages the resources of the cluster for the user and executes processes remotely to share the computation load among the nodes in the cluster.\nThe benefits of cluster computing are well known. A large class of computations can be broken into smaller pieces and executed by the various nodes in a cluster. Sometimes, however, it can be beneficial to run an application on a Beowulf cluster that was not designed to be cluster-aware. This is one of the main goals of PANTS.\nPANTS was designed to be transparent to the application as well as the programmer. This transparency allows an increased range of applications to benefit from process migration. Under PANTS, existing multi-process applications, not built with cluster computing in mind, can now run on multiple nodes by invisibly migrating the individual processes of the application. AS far as the application is concerned, it is running on a single computer, while PANTS controls what resources it is using.\nThe PANTS design also contains a method for minimal inter-node communication and fault tolerance. In a Beowulf system, the network is most often the performance bottleneck. With this in mind, PANTS keeps the number of messages that move between machines low and also uses a protocol which does not exchange messages with nodes busy with computation. Built-in fault tolerance allows the cluster to continue functioning even in the event that a node fails. In the same way, nodes can be added or removed from a cluster without dramatic consequences.
Performance Evaluation of a Method to Improve Fairness in In-Vehicle Non-Destructive Arbitration Using ID Rotation (2017)

A number of automotive electronics-safety, driver assistance, and infotainment devices-have been deployed in recent vehicles. This raises new challenges regarding in-vehicular network arbitration. A performance analysis of non-destructive arbitration has revealed a fairness issue. The arbitration prioritizes without collisions, despite multiple simultaneous transmissions; however, the performances of the highest priority node and the lowest priority node are very different. In this paper, an ID-rotation arbitration method to solve the arbitration-fairness problem is proposed. The proposed algorithm was applied to several engine control units (ECUs), including a controller area network (CAN) controller. Experimental results showed that the algorithm improved the fairness as well as the total throughput within a specific performance constraint.
Emission of Spermatozoa <i>Age of Onset</i> (1979)

The determination of the age at which the first release of spermatoza takes place in boys – spermarche, has been hampered by social and ethical considerations. Based on observation by Baldwin (1928) that spermatozoa can be detected in urine specimen after emission of spermatozoa, we conducted a cross sectional study on 429 Israeli school boys aged 11–16, in order to estimate the age of spermarche. Based on the collection of at least three consecutive urine samples from most of the boys, the median age of spermarche was estimated to be 14.5. These findings confirm previous assumption based on retrospective questionnaires and correlate well with histological findings at the age of onset spermatogenesis. Among the boys with spermaturia the frequency of positive findings was one out of the two days in the age group of 12 years while it was one out of three days in the 15–16 year old older boys, with an intermediate frequency in the 13 years old.
Atomic layer deposition of thin inorganic coatings onto renewable packaging materials (2011)

Biopolymers play still a relatively minor role in the packaging material markets. For this to grow further there are problems to be solved, such as inadequate barrier properties and moisture sensitivity. Atomic layer deposition (ALD) is one potential solution. Atomic layer deposition is a layer-by-layer thin film deposition process based on self-limiting gas-solid reactions. It is well suited for producing pinhole free barrier coatings uniform in thickness at relatively mild process conditions. The purpose of this presentation is to summarize our recent work done concerning atomic layer deposition of thin aluminum oxide layers onto biopolymers.
The Relation Between Quantitative MRI Measures of Hippocampal Structure and the Intracarotid Amobarbital Test (1997)

We conclude that patients with unilateral hippocampal sclerosis, established by a rigorous quantitative MRI protocol, and concordant ictal and interictal EEG findings may not be at risk for postoperative amnesia, despite baseline neuropsychological deficits suggestive of bilateral disturbance.
Selective inhibition of persistent sodium current by F 15845 prevents ischaemia‐induced arrhythmias (2010)

F 15845, a novel anti-anginal drug targeting I(Nap), demonstrates new anti-arrhythmic properties which may be of therapeutic benefit against ischaemia-induced arrhythmias.
Informatics in Radiology (<b><i>info</i></b>RAD) (2004)

Computer-aided analysis of medical images usually involves the development of custom software applications that interpret, process, and ultimately display medical image data. The interpretation stage involves decoding the image data and presenting them to the application developer for further processing. A toolkit has been created specifically for interpreting medical image data; it thus acts as a platform for development of medical imaging applications. The toolkit, which is referred to as NeatMed, is intended to reduce development time by eliminating the need for the application developer to deal directly with medical image data. NeatMed was implemented by using Java, a programming language with a range of attractive features including ease of use, extensive support material, and portability. NeatMed was developed specifically for use in a research environment. Straightforward to use and well documented, it is intended as an alternative to commercially available medical imaging toolkits. NeatMed currently provides support for the Digital Imaging and Communications in Medicine and Analyze medical image file formats. Support material including sample source code is available via the Internet; links to related resources are also provided. Most important, NeatMed is freely available and its continuing development is motivated by requests and suggestions from end users.
Tunable optical sectioning in confocal microscopy by use of symmetrical defocusing and apodization (1998)

We present two novel optical methods to achieve a significative improvement in the optical-sectioning capacity of confocal scanning microscopes. The techniques, whose real power is the simplicity with which they can be implemented, consist of a suitable combination of symmetrical defocusing with two different manners of apodizing both parts of the confocal architecture. It is shown that the proposed techniques are useful in both the bright-field and the fluorescence modes and for reflection and transmission geometries.
Forming Limit Curves in Blow Molding for a Polymer Exhibiting Deformation Induced Crystallization (2002)

International audience
Bis‐desulfoglucosinolates: A New Class of Bolaforms. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Lempel-Ziv complexity of cortical activity during sleep and waking in rats (2015)

Understanding the dynamics of brain activity manifested in the EEG, local field potentials (LFP), and neuronal spiking is essential for explaining their underlying mechanisms and physiological significance. Much has been learned about sleep regulation using conventional EEG power spectrum, coherence, and period-amplitude analyses, which focus primarily on frequency and amplitude characteristics of the signals and on their spatio-temporal synchronicity. However, little is known about the effects of ongoing brain state or preceding sleep-wake history on the nonlinear dynamics of brain activity. Recent advances in developing novel mathematical approaches for investigating temporal structure of brain activity based on such measures, as Lempel-Ziv complexity (LZC) can provide insights that go beyond those obtained with conventional techniques of signal analysis. Here, we used extensive data sets obtained in spontaneously awake and sleeping adult male laboratory rats, as well as during and after sleep deprivation, to perform a detailed analysis of cortical LFP and neuronal activity with LZC approach. We found that activated brain states-waking and rapid eye movement (REM) sleep are characterized by higher LZC compared with non-rapid eye movement (NREM) sleep. Notably, LZC values derived from the LFP were especially low during early NREM sleep after sleep deprivation and toward the middle of individual NREM sleep episodes. We conclude that LZC is an important and yet largely unexplored measure with a high potential for investigating neurophysiological mechanisms of brain activity in health and disease.
NashDB (2018)

Distributed data management systems often operate on "elastic'' clusters that can scale up or down on demand. These systems face numerous challenges, including data fragmentation, replication, and cluster sizing. Unfortunately, these challenges have traditionally been treated independently, leaving administrators with little insight on how the interplay of these decisions affects query performance. This paper introduces NashDB, an adaptive data distribution framework that relies on an economic model to automatically balance the supply and demand of data fragments, replicas, and cluster nodes. NashDB adapts its decisions to query priorities and shifting workloads, while avoiding underutilized cluster nodes and redundant replicas. This paper introduces and evaluates NashDB's model, as well as a suite of optimization techniques designed to efficiently identify data distribution schemes that match workload demands and transition the system to this new scheme with minimum data transfer overhead. Experimentally, we show that NashDB is often Pareto dominant compared to other solutions.
Ring opening of 5,7-dimethyl-v-triazolo[1,5-a]pyrimidine by halogenating agents (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing opening of 5,7-dimethyl-v-triazolo[1,5-a]pyrimidine by halogenating agentsThomas Novinson, Phoebe Dea, and Takayuki OkabeCite this: J. Org. Chem. 1976, 41, 2, 385–388Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/jo00864a050https://doi.org/10.1021/jo00864a050research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification and Characterization of a New Intermediate in the Ribosylative Inactivation Pathway of Rifampin by <i>Mycobacterium smegmatis</i> (1999)

Mycobacterium smegmatis DSM 43756 inactivates rifampin by ribosylation. To study this process of rifampicin, all possible inactivated forms of the antibiotic were extracted and purified. Structural studies showed the presence of a new inactivation product, designated RIP-TAp(23-phosphoribosyl-rifampin). Formation of 23-(O-ADP-ribosyl)rifampin (RIP-TAs) is the first step, followed by removal of AMP to give rise to the newly identified compound. Lastly, dephosphorylation leads to formation of 23-ribosyl-rifampin (RIP-Mb). Feeding experiments with the ADP-ribosylated antibiotic obtained from the cell homogenates of an Escherichia coli strain carrying the cloned M. smegmatis gene confirmed this rifampin inactivation process.
Picture processing using one-dimensional implementations of discrete planar filters (1974)

The problem of implementing a two-dimensional recursive filter as a one-dimensional recursive filter is examined. The results of the present paper show that the exact one-dimensional implementation of a planar recursive filter is a time-varying filter. However, planar filters may be approximated by one-dimensional time-invariant recursive filters. The frequency response, stability, and storage requirements of the approximate filters are derived and illustrated.
Amplified pixel sensor architectures for low dose computed tomography using silicon thin film technology (2007)

Cone beam computed tomography (CBCT) has been recently reported using flat panel imagers (FPI). Here, detector technology capable of high speed imaging, high spatial resolution, large volume coverage, better contrast resolution and, in particular, lowered patient dose is required. Employing active matrix flat panel imagers (AMFPIs) as cone beam CT detectors has been proposed as a solution for improving volume coverage, contrast and resolution; however, clinical evaluations have shown that they suffer from low speed read out. Unlike passive pixel architecture which is currently the state-of-the-art technology for AMFPIs, our preliminary studies have shown that novel amplified pixel sensor (APS) architectures can overcome the low readout speed, and moreover, they provide gain which can be traded for higher frame rate and lower X-ray doses. Although APS architectures can meet the high dynamic range and low noise requirements of CT imaging, linearity and variations between pixel characteristics are major issues. In this study we will investigate novel APS architectures to address these concerns.
Sequences outside a minimal immunodominant site exert negative effects on recognition by staphylococcal nuclease-specific T cell clones. (1989)

In recent years, synthetic peptides have been utilized extensively to characterize the minimal essential immunodominant sites on model protein Ag. However, little work has focused on the effect that sequences flanking these minimal recognition sites may exert on T cell recognition. Previous work with staphylococcal nuclease (Nase) demonstrated that I-Ek-restricted clones recognize the peptide 81-100, whereas I-Ab-restricted clones recognize the over-lapping but non-cross-reacting peptide 91-110. Further analysis with 15 or 10 residue peptides within the region 81-110 reveals that the minimal sequence capable of stimulating I-Ek-restricted clones is contained within the decapeptide 91-100. Addition of residues 86-90, to give the peptide 86-100, enhanced the recognition substantially, whereas addition of residues 101-105 produced a 91-105 peptide with no stimulatory ability. These results suggest that interactions between the antigenic peptide 91-100 and residues within the flanking 101-105 sequence have negative consequences for presentation of the immunodominant epitope to T cell clones. Introduction of single amino acid substitutions within 91-105 produced peptides that induce responses comparable to those seen with 91-100. These results are consistent with the suggestion of negative interactions between the minimal immunodominant site and flanking sequences in that single residue substitutions may remove these negative interactions and lead to restoration of stimulatory ability. The negative effect of flanking sequences on T cell recognition of immunodominant sites presents new considerations for development of synthetic vaccines as well as for understanding the biology of Ag processing and presentation.
Sensor Setups for State and Wind Estimation for Airborne Wind Energy\n Converters (2013)

An unscented Kalman filter with joint state and parameter estimation is\nproposed for aerodynamics, states and wind conditions for airborne wind energy\nconverters. The proposed estimator relies on different measurement setups. Due\nto the strict economic constraints of wind energy converters, the sensor setups\nare chosen with minimal cost and reliability issues in mind. Simulation data\nwith a high fidelity system model and experimental tests using flight data,\ntogether with wind measurements obtained using a lidar system for altitude wind\nmeasurements, are used for validation. The data was obtained during test\nflights of the EnerK\\'ite EK30, an airborne wind energy converter currently in\nresearch operation in Brandenburg, Germany. Feasible accuracies were achieved\neven with the simplest of setups and illustrate the gain achievable by airborne\nsensors. Additionally, the results encourage further research into use of the\nobtained wind estimates for site assessment.\n