gebhart/patrepeval huggingface dataset:
Optimising the cloud infrastructure: tool design and a case study (2014)

It has been predicted in a cloud management survey, that over 68% of production workloads in the USA will be virtualised by 2013, which is almost 25% more than in 2010 (IDC Private Cloud Management Study). However, virtualisation will not deliver its full potential unless it is carefully managed to achieve the adequate consolidation density within acceptable performance risk. In this paper, we describe an interactive, what-if analysis driven, planning tool to manage and optimise virtualised/cloud environments. The analysis is performed based on usage data, discovered configuration, policies and other meta-data. The recommended optimisation plan may suggest possible savings based on various cost factors. The paper also describes a case study of how we have applied the tool in an IBM internal cloud and present some insights and learning. Based on several what-if analysis scenarios we demonstrated, 100+ more virtual machines can be accommodated in the existing cloud, resulting in improved ROI.
Les opérateurs virtuels mobiles sont pris en tenaille en tenaille entre les opérateurs et le marché (2006)

info:eu-repo/semantics/published
Ga-PSMA PET/CT Staging of Newly Diagnosed Intermediate- and High-Risk Prostate Cancer. (2019)

Ga-PSMA PET/CT shows promise as a sole whole-body imaging modality for assessing the presence of soft tissue and bone metastases in the setting of prostate cancer.
Anionic Polymerization of Acrylates. Synthesis of (Meth)acrylate Di- and Triblock Copolymers Using the Li Ester−Enolate/<i>tert-</i>Alkoxide Initiating System (2003)

Methacrylate di- and triblock copolymers composed of methyl (MMA), butyl (BuMA), 2-(dimethylamino)ethyl (DMAMA), and 2-ethylhexyl (EtHMA) methacrylates and tert-butyl acrylate (t-BuA) blocks were prepared by ligated anionic polymerization and characterized by SEC and NMR. The process was initiated with the system methyl 2-lithioisobutyrate/lithium tert-butoxide (MIB−Li/t-BuOLi) at the 1/10 mole ratio, which was recently described as the optimum composition, at THF at −60 °C. The monomers were added to the reaction mixture successively after chosen polymerization intervals and products of the individual polymerization steps were isolated and analyzed. Molecular weights of methacrylate copolymers increased with increasing total amount of the monomers added, and the products of the two- or three-step polymerizations were not detectably contaminated with the products of the foregoing steps, so that the corresponding MWD curves were unimodal and symmetric. The product of MMA/t-BuA block copolymerization exhibited bimodal MWD, originating probably by the self-termination proceeding at the beginning of the second polymerization step after addition of an acrylate monomer to the "living" polymethacrylate. A possible mechanism of self-termination and reactions of polymethacrylate chains bearing a few terminal acrylate units are briefly discussed.
A MORE BIOLOGICALLY MOTIVATED GENETIC ALGORITHM: THE MODEL AND SOME RESULTS (1994)

For more than two decades, genetic algorithms (GAs) have been studied by researchers from different fields. Over the years, many modifications have been suggested to alleviate the difficulties encountered by GAs in solving different problems. Despite these modifications, with the increase in application traditional GAs remain inadequate for many practical purposes. This paper introduces a new genetic model called the structured genetic algorithm (sGA) to address some of the difficulties encountered by the simple genetic approaches in solving various types of problems. The novelty of this genetic model lies primarily in its redundant genetic material and a gene activation mechanism that utilizes a multilayered structure for the chromosome. This representation provides genetic variation and has many advantages in search and optimization. For example, it can retain multiple (alternative) solutions or parameter spaces in its representation. In effect, it also works as a long-term distributed memory within the population, enabling rapid adaptation in non stationary environments. Theoretical arguments and empirical studies are presented which demonstrate that the sGA can more efficiently solve complex problems than simple GAs. It is also noted that the sGA exhibits greater implicit nondisruptive diversity than other exist-
A universal steady state I-V relationship for membrane current (1995)

A purely electrical mechanism for the gating of membrane ionic channel gives rise to a simple I-V relationship for membrane current. Our approach is based on the known presence of gating charge, which is an established property of the membrane channel gating. The gating charge is systematically treated as a polarization of the channel protein which varies with the external electric field and modifies the effective potential through which the ions migrate in the channel. Two polarization effects have been considered: 1) the up or down shift of the whole potential function, and 2) the change in the effective electric field inside the channel which is due to familiar effect of the effective reduction of the electric field inside a dielectric body because of the presence of surface charges on its surface. Both effects are linear in the channel polarization. The ionic current is described by a steady state solution of the Nernst-Planck equation with the potential directly controlled by the gating charge system. The solution describes reasonably well the steady state and peak-current I-V relationships for different channels, and when applied adiabatically, explains the time lag between the gating charge current and the rise of the ionic current. The approach developed can be useful as an effective way to model the ionic currents in axons, cardiac cells and other excitable tissues.
First Chemical Transformations of Lanthanide Borohydride Compounds:  Synthesis and Crystal Structures of [(η-C<sub>8</sub>H<sub>8</sub>)Nd(BH<sub>4</sub>)(THF)]<sub>2</sub> and [(η-C<sub>8</sub>H<sub>8</sub>)Nd(THF)<sub>4</sub>][BPh<sub>4</sub>] (1998)

Reaction of Nd(BH4)3(THF)3 with K2COT (COT = η-C8H8) in tetrahydrofuran (THF) gave the first (cyclooctatetraene)lanthanide borohydride, (COT)Nd(BH4)(THF)2 (1). By treatment with NHEt3BPh4, 1 was transformed into [(COT)Nd(THF)4][BPh4] (3), a unique example of a (cyclooctatetraene)lanthanide cation; both 1 and 3 gave (COT)Nd(Cp*)(THF) (Cp* = η-C5Me5) upon reaction with KCp*.
Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver (1998)

1. The influence of short-term cold storage in University of Wisconsin organ preservation solution (UW) on the ability to metabolize lidocaine, testosterone and 7-ethoxycoumarin in isolated human and cynomolgus monkey (Macaca fascicularis) hepatocytes and liver slices has been investigated. 2. The human liver tissue was obtained from two different sources, i.e. healthy liver tissue from patients undergoing partial hepatectomy because of metastases of colorectal carcinoma (PH livers) and donor tissue remaining as surgical waste after reduced size or split liver transplantation (Tx livers). Tx livers were perfused in situ with ice-cold UW avoiding warm ischaemia. This in contrast with PH livers, where the operation caused warm ischaemia for 5-90 min. 3. Liver slices and hepatocytes from cynomolgus monkey liver showed comparable metabolic rates for the substrates tested, indicating that all hepatocytes in the slice are participating in the biotransformation of the substrates. These monkey liver preparations can be stored up to 18 h with only a slight loss of their metabolic capacity. 4. Liver slices and isolated hepatocytes from the Tx livers as well as isolated cells from the PH livers could also be stored up to 18 h without losing metabolic capacity. However, for liver slices prepared from PH livers cold storage is not recommended, because metabolic function was reduced by approximately 40% after 18 h.
Polyethylene/sepiolite fibers. Influence of drawing and nanofiller content on the crystal morphology and mechanical properties (2014)

The influence of sepiolite content (1, 2, and 3 wt%) and successive drawing steps on the final properties of polyethylene/sepiolite nanocomposite fibers are reported. Particularly the effects of these variables on crystallinity, fiber macroscopic morphology, and tensile mechanical properties are analyzed applying different experimental techniques: differential scanning calorimetry, wide angle x‐ray diffraction, scanning electronic microscopy, and tensile mechanical characterization. The study evidenced the important role of both sepiolite content and stretching on the crystalline morphology and mechanical properties of the nanocomposites fiber. Both variables favor the appearance of the monoclinic phase during polyethylene crystallization, and produce an increase of crystallinity degree (35 % with drawing steps and 10 % by the sepiolite incorporation in non drawing fiber). This change of crystal morphology influences mechanical properties enhancing with both sepiolite content and drawing steps. Thus, Young Modulus increases 17 times with drawing in pure PE fibers and 1.5 times because sepiolite presence. The strength shows similar behavior, but the elongation at break decreases 14 timed with draw steps and to a half by the sepiolite influence. The final properties of drawing nanocomposite fibers are so acceptable for textile applications and they content particles that enhance their moisture and odors absorptive capacities. POLYM. ENG. SCI., 55:1096–1103, 2015. © 2014 Society of Plastics Engineers
Articles : HBV Polymerase Residues Asp429 and Asp551 , Invariant at Mopdfs A and C are Essential to DNA Binding (1998)

HBV polymerase shares several regions of amino acid homology with other DNA-directed and RNA-directed polymerases. The amino acid residues Asp^(429), Gly^(518), Asp^(551), Lys^(585), and Gly^(641) in the conserved motifs A, B`, C, D, and E in the polymerase domain of HBV polymerase were mutated to alanine or histidine by in vitro site-directed mutagenesis. Those mutants were overexpressed, purified, and analyzed against DNA-dependent DNA polymerase activity and affinity for DNA binding. All those mutants did not show DNA-dependent DNA polymerase activities indicating that those five amino acid residues are all critical in DNA polymerase activity. South-Western analysis shows that amino acid residues Asp^(429) and Asp^(551) are essential to DNA binding, and Gly^(518) and Lys^(585) also affect DNA binding to a certain extent.
Electrooxidation Mechanism of Biogenic Amines at Amine Oxidase Modified Graphite Electrode (2000)

Amine oxidase (AO, EC. 1.4.3.6) was previously shown to be a very efficient biological recognition element of amperometric biosensors for monitoring biogenic amines. The enzyme was effectively working in both mono- and bienzyme electrode designs, based on either a direct or a mediated electron-transfer pathway. This work focuses on the elucidation of the electron-transfer mechanism of the monoenzymatic unmediated AO-modified biosensor. The observed unmediated catalytic currents were assumed to be caused by (i) a direct electron-transfer process, (ii) the electrooxidation of the formed product, or (iii) their combination. Experiments supporting these assumptions are discussed in detail.
Total Suppression of Ventricular Arrhythmias by Encainide (1980)

We studied the antiarrhythmic effect of a range of oral doses of encainide in 11 patients with stable high-frequency ventricular arrhythmias. Total suppression of arrhythmia was documented in 10 patients at a wide range of doses and plasma concentrations, and the suppression was subsequently verified in a placebo-controlled crossover study. Drug elimination was rapid (the half-life was 1.9 to 3.8 hours), but the margin between efficacy and side effects was sufficiently wide for therapy every six to 12 hours to be feasible in all 10 patients, with continuing outpatient treatment at six to 12 months. Marked prolongation of PR (mean, 44 per cent) and QRS (mean, 47 per cent) durations coincided with abolition of arrhythmia, but no evidence that these effects were detrimental was observed in radionuclide ventriculograms, exercise testing, or prolonged monitoring. A single patient whose arrhythmia and electrocardiogram were unchanged during therapy eliminated the drug much more slowly than the others and was the only patient in whom no O-demethyl form could be detected in plasma, suggesting that this metabolite may be active. In this study, encainide was a highly effective, well-tolerated antiarrhythmic agent.
INFUSION OF CITRUS FRUIT PEEL BY LOW‐PRESSURE FLUID INJECTION USING A SELF‐SEALING NOZZLE (1998)

ABSTRACT Removal of citrus peel is facilitated by infusion of water into the peel. A low‐pressure fluid injection (LPFI) technique was developed to improve infusion efficacy. Water under low pressure (340 to 1700 mbar) was forced through an opening formed near the equator of the fruit. The water spread uniformly throughout the albedo before exiting through an additional hole made on the opposite side of the fruit. Increasing pressure and flow rate reduced injection time, but excessive levels created high internal pressures that occasionally caused peels to rupture. A rubber bulb with an orifice at the tip created a nozzle that produced a water‐tight interface with the fruit during injection.
Interferon Alpha-2a for Subfoveal Neovascularization in Age-Related Macular Degeneration (1996)

Background: The current study is a prospective randomized clinical trial to determine the effect of interferon alpha-2a on eyes with subfoveal subretinal neovascularization secondary to age-related macular degeneration (AMD). Methods: Twenty eyes of 19 patients with subfoveal neovascularization secondary to AMD were prospectively evaluated. Ten eyes were randomized to subcutaneous interferon alpha-2a (3 million units/m 2 ) every other day for 8 weeks, whereas 10 eyes were randomized to observation alone as controls. Fluorescein angiography, best-corrected visual acuity tests, and macular visual field assessments were performed, and all eyes were followed for a minimum of 6 months. Results: At the 2-month follow-up visit, the interferon group manifested somewhat slower neovascular growth than controls, but the results were not statistically significant. At the 6-month follow-up visit, there was no difference in visual acuity, average macular sensitivities, or extent of neovascularization. The rate of neovascular progression was significantly related to the extent of previous macular photocoagulation in both groups. Conclusion: Though the rate of neovascular progression was slowed during the second month of interferon treatment, the effect did not persist once interferon was discontinued. No long-term benefit appeared to be present. Unfortunately, lengthening the time of administration, increasing the dosage, or increasing the frequency of administration would likely give rise to unacceptable side effects.
Phosphoenolpyruvat-Carboxylasen in Solanum tuberosum : Charakterisierung und Expression (2000)

A model for the photorespiratory reduction in C3 plants has been developed at the department of Biology 1 (RWTH-Aachen) which proposes the development of a prefixing CO2 mechanism in the model plant Solanum tuberosum. A central role therein is the initial carboxylation reaction catalysed by the enzyme phosphoenolpyruvate-carboxylase (PEPC). This thesis presents research into increasing this enzyme’s activity in S.tuberosum. Two clones carrying the stppc1 or the stppc2 gene were isolated from a S.tuberosum genomic phage bank by plaque and Southern hybridisation. The inserts of the phage clones were subcloned and the complete genomic sequence of the stppc2 gene (8438 bp; EMBL Accession Number AJ011844) and the promoter sequence of the stppc1 gene (873 bp; EMBL Accession Number AJ278827) were determined. There are at least three copies of the ppc gene present in S.tuberosum as shown by Southern hybridisation. The stppc1 gene could be detected in all leaf cells using in situ-hybridisation of S.tuberosum leaf cross sections. Through crossing or self-fertilisation of transgenic lines containing the highly expressed phosphoenolpyruvate-carboxylase (PEPC)-gene from Corynebacterium glutamicum, plants were produced in which the PEPC activity was detected to be 6 times higher than in the parental plants. Similarly, F1-descendants were obtained in which the phosphoenolpyruvate synthase gene from E.coli, as well as the C. glutamicum-PEPC gene, was also expressed. The respective proteins were detected in the F1-descendants by western blots and enzyme assays. They were also analysed for their content of physiologically important metabolites to see if there was a correlation between the plant’s metabolite content and the PEPC activity or the total amount of PEPS in the plant. In plants with over-expressed PEPC activity, the amount of some metabolites rises with an increase in the enzyme’s activity. This is in contrast to the F1-plants expressing both foreign enzymes in which on the whole the amount of some metabolites decreased.
Relationship of Germinal Centers in Lymphoid Tissue to Immunologic Memory (1968)

Summary Cell suspensions, obtained from white and red pulp of rabbit spleens at various days after priming, were examined for their ability to respond, with increased proliferation, to reexposure to antigen. A comparison was made between the proliferative response and the secondary in vitro antibody response obtained with the same tissues. A significant increase in mitotic activity in response to antigen was seen in white pulp as early as day 3 after priming. The maximum response was obtained on days 7 to 10. Neither of the antigens elicited a significant proliferative response in red pulp cells. However, in view of an unusually high background activity found in many of the red pulp suspensions, a limited stimulatory effect of antigen may have gone undetected. A fairly good correlation was found between the proliferative and secondary antibody response of white and red pulp and a relationship to the development of germinal centers in the white pulp was suggested. The first striking responsiveness occurred at the time when germinal centers are beginning to form, and maximum responsiveness was noted at the time of their peak development.
Rotational analysis of the 7<i>p</i>σ 3Σ+<i>g</i>←<i>a</i>3Σ+<i>u</i> system of the Ar2 molecule (1994)

Rotationally resolved transitions from the metastable 4sσ a3Σ+u state of Ar2 to the 7pσ 3Σ+g state have been observed by laser excitation spectroscopy in a pulsed corona discharge. Laser induced fluorescence spectra for the 7pσ 3Σ+g←a3Σ+u transition observed near 19 530 cm−1 have led to the first resolved triplet splittings and rotational analyses for Rydberg–Rydberg transitions in Ar2. Analyses for the (0–0), (0–1), (1–0), and (1–1) bands of 7pσ←a are presented here. Bands with v′=2 are observed for this system but exhibit no rotational structure and bands with v′≳2 are not observed, indicating that the predissociation lifetimes of these upper levels fall rapidly for v′≳1. Data presented lead to rotational energies and molecular constants for the a3Σ+u and 7pσ 3Σ+g states, including the effective rotational constant Be which is determined to be 0.1412 cm−1 and 0.1345 cm−1 for the 4sσ a3Σ+u and 7pσ 3Σ+g states, respectively. Results are compared to ab initio and other calculations, and combined with existing data to produce experimental estimates of D0 and De for the a3Σ+u state of 5700±200 cm−1 and 5850±200 cm−1, respectively.
Nuclear Targeting by the Growth Factor Midkine (2002)

Ligand-receptor internalization has been traditionally regarded as part of the cellular desensitization system. Low-density lipoprotein receptor-related protein (LRP) is a large endocytosis receptor with a diverse array of ligands. We recently showed that LRP binds heparin-binding growth factor midkine. Here we demonstrate that LRP mediates nuclear targeting by midkine and that the nuclear targeting is biologically important. Exogenous midkine reached the nucleus, where intact midkine was detected, within 20 min. Midkine was not internalized in LRP-deficient cells, whereas transfection of an LRP expression vector restored midkine internalization and subsequent nuclear translocation. Internalized midkine in the cytoplasm bound to nucleolin, a nucleocytoplasmic shuttle protein. The midkine-binding sites were mapped to acidic stretches in the N-terminal domain of nucleolin. When the nuclear localization signal located next to the acidic stretches was deleted, we found that the mutant nucleolin not only accumulated in the cytoplasm but also suppressed the nuclear translocation of midkine. By using cells that overexpressed the mutant nucleolin, we further demonstrated that the nuclear targeting was necessary for the full activity of midkine in the promotion of cell survival. This study therefore reveals a novel role of LRP in intracellular signaling by its ligand and the importance of nucleolin in this process.
Endocardial motion estimation from electro-anatomical data (2012)

An accurate scar characterization plays an essential role for the treatment of ventricular tachycardia in patients with ischemic cardiomyopathy. Cardiac ablation based on electrical information is a widely used procedure to fix ventricular tachycardia. However, intra-operative scar characterization may be improved using mechanical information together with the electrical data. We propose in this paper a method to reconstruct the endocardial motion intra-operatively by exploiting both information from an electro-anatomical mapping system and the heart anatomy segmented from any pre-operative 3D imaging modality, using a bilinear statistical atlas to approximate motion in the areas where no information is provided. We applied the proposed methodology to four patients with ischemic cardiomyopathy. The results showed abnormal strain curves in presence of scar, which was defined using contrast-enhanced magnetic resonance images.
Properties of Minimizers of Average-Distance Problem via Discrete Approximation of Measures (2013)

Given a finite measure $\mu\geq 0$ with compact support, and $\lambda >0$, the average-distance problem, in the penalized formulation, is to minimize $E_\mu^\lambda(\Sigma):= \int_{\mathbb{R}^d} d(x,\Sigma)d\mu(x)+\lambda \mathcal{H}^1(\Sigma)$ among pathwise connected, closed sets, $\Sigma$. Here $d(x, \Sigma)$ is the distance from a point to a set and $\mathcal{H}^1$ is the 1-Hausdorff measure. In a sense the problem is to find a one-dimensional measure that best approximates $\mu$. The minimizer, $\Sigma$, is topologically a tree whose branches are rectifiable curves. The branches may not be $C^1$, even for measures $\mu$ with smooth density. Here we show a result on weak second-order regularity of branches. Namely, we show that arc-length-parameterized branches have $BV$ derivatives and provide a priori estimates on the $BV$ norm. The technique we use is to approximate the measure $\mu$, in the weak-$*$ topology of measures, by discrete measures. Such approximation is also relevant for numerical computations. We prove the stability of the minimizers in appropriate spaces and also compare the topologies of the minimizers corresponding to the approximations with the minimizer corresponding to $\mu$ and obtain a topological lower-semicontinuity result.