gebhart/patrepeval huggingface dataset:
Successful Combination of Sunitinib and Girentuximab in Two Renal Cell Carcinoma Animal Models: A Rationale for Combination Treatment of Patients with Advanced RCC (2015)

Anti-angiogenic treatment with tyrosine kinase inhibitors (TKI) has lead to an impressive increase in progression-free survival for patients with metastatic RCC (mRCC), but mRCC remains largely incurable. We combined sunitinib, targeting the endothelial cells with Girentuximab (monoclonal antibody cG250, recognizing carbonic anhydrase IX (CAIX) targeting the tumor cells to study the effect of sunitinib on the biodistribution of Girentuximab because combination of modalities targeting tumor vasculature and tumor cells might result in improved effect. Nude mice with human RCC xenografts (NU12, SK-RC-52) were treated orally with 0.8 mg/day sunitinib, or vehicle for 7 to 14 days. Three days before start or cessation of treatment mice were injected i.v. with 0.4 MBq/5 μg (111)In-Girentuximab followed by biodistribution studies. Immunohistochemical analyses were performed to study the tumor vasculature and CAIX expression and to confirm Girentuximab uptake. NU12 appeared to represent a sunitinib sensitive tumor: sunitinib treatment resulted in extensive necrosis and decreased microvessel density (MVD). Accumulation of Girentuximab was significantly decreased when sunitinib treatment preceded the antibody injection but remained unchanged when sunitinib followed Girentuximab injection. Cessation of therapy led to a rapid neovascularization, reminiscent of a tumor flare. SK-RC-52 appeared to represent a sunitinib-resistant tumor: (central) tumor necrosis was minimal and MVD was not affected. Sunitinib treatment resulted in increased Girentuximab uptake, regardless of the sequence of treatment. These data indicate that sunitinib can be combined with Girentuximab. Since these two modalities have different modes of action, this combination might lead to enhanced therapeutic efficacy.
Power control in lognormal fading wireless channels with uptime probability specifications via robust geometric programming (2005)

This paper concerns power control in lognormal fading wireless channels with correlated interference. We consider an outage-based quality of service (QoS) specification, which requires the uptime probability, i.e., the probability that no transmitter/receiver pair experiences any outage due to fading, is kept above a given level. The problem of finding an optimal power allocation to achieve this QoS goal over lognormal fading wireless channels can be posed as a stochastic geometric program (GP) with joint probabilistic constraints. This stochastic geometric program is extremely hard to solve in general, compared with the stochastic GP associated with Rayleigh fading channels. In this paper, we describe a suboptimal approach based on recently proposed robust geometric programming. With a good compromise between computational efficiency and accuracy, this robust GP relaxation approach finds a power allocation which meets the QoS requirement on the uptime probability. A numerical example is given to demonstrate the method.
Enniatin production by fusarium strains and its effect on potato tuber tissue (1996)

Several Fusarium strains produce the cyclohexadepsipeptide enniatin, a host-nonspecific phytotoxin. Enniatins are synthesized by the 347-kDa multifunctional enzyme enniatin synthetase. In the present study, 36 Fusarium strains derived from a wide range of host plants were characterized with respect to enniatin production in different media. Thirteen of these strains produced enniatins on one or more of these media. To determine whether enniatin production affected virulence, an assay on potato tuber tissue was performed. Seven enniatin-producing and 16 nonproducing strains induced necrosis of potato tuber tissue, so that enniatin synthesis is not essential for the infection of potato tuber tissue. The application of a mixture of enniatins to slices of potato tuber, however, caused necrosis of the tissue. Therefore, enniatin production by the enniatin-synthesizing strains may affect their pathogenicity. The enniatin synthetase gene (esyn1) of Fusarium scirpi ETH 1536 was used as a probe to determine if similar sequences were present in the strains examined. In Southern blot analyses, DNA sequences hybridizing with the esyn1 probe were present in all but two of the strains examined. In some cases, enniatin-nonproducing strains had the same hybridization pattern as enniatin producers.
Dual Microcatheter Technique for the Treatment of Aneurysms with Relatively Wide Necks (2006)

The use of stents or balloons in treating relatively wide-necked aneurysms carries a significant risk in the setting of unfavorable anatomy. Alternate techniques to prevent herniation of coils into the parent vessel might reduce the risk of injury. Since 2000, we have used a dual microcatheter technique in a select group of patients in order to stabilize the coil mass. Between 2000 and 2005, 20 patients underwent a modified technique for aneurysm treatment. Two microcatheters were advanced through a 6-French guiding catheter into the aneurysm, and coils were sequentially deployed through each microcatheter. Once a stable coil frame was achieved with no evidence of coil protrusion, one of the coils was detached. Subsequent coils were deployed until adequate aneurysm occlusion was achieved, usually with detachment of the first framing coil last. All aneurysms measured between 5 and 18 mm, with necks measuring between 3.5 and 10 mm. The dome-to-neck ratio...
A high performance floating point coprocessor (1984)

A 34000-transistor single-chip floating-point coprocessor fabricated in 3-/spl mu/m double metal NMOS technology is described. The fraction data path, including a shifter and 60-bit carry propagate ALU, is cycled in 100 ns for all operations requiring less than 19 bits of consecutive carry. A versatile carry length detection scheme, which requires minimal additional logic, is used to extend the microcycle for the small percentage of operations in which a long carry exists. Three-bit-per-cycle multiplication and one-and-one-half-bit-per-cycle division algorithms were used to achieve excellent overall performance.
E-field fiber-tip sensor by exploiting the electro-optic tenability of lithium niobate photonic crystals (2016)

International audience
Lateral shearing optical gradient force in coupled nanobeam photonic crystal cavities (2016)

We report the experimental observation of lateral shearing optical gradient forces in nanoelectromechanical systems (NEMS) controlled dual-coupled photonic crystal (PhC) nanobeam cavities. With an on-chip integrated NEMS actuator, the coupled cavities can be mechanically reconfigured in the lateral direction while maintaining a constant coupling gap. Shearing optical gradient forces are generated when the two cavity centers are laterally displaced. In our experiments, positive and negative lateral shearing optical forces of 0.42 nN and 0.29 nN are observed with different pumping modes. This study may broaden the potential applications of the optical gradient force in nanophotonic devices and benefit the future nanooptoelectromechanical systems.
780. Inhibition of Respiratory Syncytial Virus Gene Expression and Replication by 27mer Dicer Substrate siRNAs (2006)

Respiratory Syncytial Virus (RSV) is a leading cause of infant hospitalization worldwide. There is currently no vaccine for RSV, and treatment of acute infections is limited to supportive measures. Recent reports also implicate RSV as an important pathogen in elderly and immunocompromised populations. Because of the need for improved treatments for RSV, we are evaluating siRNA-based approaches to inhibit viral replication in vitro and in vivo. We evaluated a series of 27mer dicer substrate small interfering RNAs (siRNAs) that target the RSV A2 strain nucleocapsid, phosphoprotein, and large polymerase. The nucleocapsid and large polymerase represent novel siRNA antiviral targets. These 27mer siRNAs are asymmetrically designed to preferentially target viral messenger RNAs rather than the viral genome. Following incubation with recombinant Dicer, they are predictably cleaved to 21mer or 22mer siRNAs. We have observed a dose-dependent reduction in viral gene expression following administration of siRNAs in cell culture, including decreased viral mRNAs, viral protein, and an approximately 40-fold reduction in viral titer. These siRNAs are active over a wide dose range in cell culture, with greatest efficacy observed between 10 and 100 nM. Since siRNAs against RNA viruses could theoretically target either the positive or negative sense strand of the virus, we screened for activity against portions of the viral genome cloned non-directionally into a psiCheck2 dual luciferase vector. We observed preferential targeting of the positive sense (mRNA) of the virus by our lead siRNAs. We are also evaluating siRNAs with the opposite polarity to determine the optimal targeting method for antiviral activity. We delivered fluorescently labeled oligos to evaluate in vitro and in vivo delivery. Unformulated oligos applied to the apical surface of well-differentiated primary cultures of human airway epithelia were visualized in the cytoplasm. Similarly labeled oligos delivered intratracheally to mice were visualized in respiratory epithelia in a dose-dependent pattern. Alveolar macrophages recovered by bronchoalveolar lavage contained a significant fluorescent signal. We are applying these techniques for in vivo delivery of siRNAs targeting RSV in a mouse model of infection. Scott D. Rose and Mark A. Behlke are employed by Integrated DNA Technologies, Inc. (IDT), which has filed at least one patent application on the inventions described in this abstract, and which offers oligonucleotides for sale similar to the oligonucleotides described in this abstract. IDT is, however, not a publicly traded company, and Scott D. Rose and Mark A. Behlke personally do not own any shares or equity in IDT.
Shock compression experiments on Lithium Deuteride single crystals. (2014)

S hock compression exper iments in the few hundred GPa (multi - Mabr) regime were performed on Lithium Deuteride (LiD) single crystals . This study utilized the high velocity flyer plate capability of the Sandia Z Machine to perform impact experiments at flyer plate velocities in the range of 17 - 32 km/s. Measurements included pressure, density, and temperature between %7E200 - 600 GPa along the Principal Hugoniot - the locus of end states achievable through compression by large amplitude shock waves - as well as pressure and density of re - shock states up to %7E900 GPa . The experimental measurements are compared with recent density functional theory calculations as well as a new tabular equation of state developed at Los Alamos National Labs.
A large signal dynamic circuit model of a H2/O2 PEM fuel cell: description, parameter identification and exploitation (2008)

International audience
Traumatic Brain Injury as a Risk Factor for Schizophrenia (2007)

Traumatic brain injury (TBI) is associated with schizophrenia, but the causal nature of this relationship is not clear. Three models for their association exist: 1) TBI causes a phenocopy of schizophrenia (parallelism); 2) TBI is a marker of schizophrenia vulnerability (spurious association); and 3) TBI interacts with genetic vulnerability to cause schizophrenia (interaction or effect modification). We found that TBI is a causal component of some cases of schizophrenia, specifically those with enhanced genetic vulnerability. This has biological plausibility. Prevention of 50% of these cases could lead to a savings of $313 million annually in the United States. Further research on critical windows for traumatic brain injury in vulnerable individuals could shed light on the developmental pathophysiology of schizophrenia.
Dynamics of Two Interacting Bose-Einstein Condensates (1999)

We analyze the dynamics of two trapped interacting Bose-Einstein condensates in the absence of thermal cloud and identify two regimes for the evolution: a regime of slow periodic oscillations and a regime of strong nonlinear mixing leading to the damping of the relative motion of the condensates. We compare our predictions with an experiment recently performed at JILA.
Perceived quality in fresh peaches: an approach through structural equation modeling (2011)

The quality requirements that consumers consider in their decision to purchase fresh fruit have garnered a great deal of attention from the actors in the fresh fruit productivity chain. This study seeks to identify attributes that could explain how a consumer of fresh peaches perceives quality. The focus on the peach was because of the limited knowledge of the signs of quality that the consumer is seeking in this fruit. As a result, the objective was to produce a model that explains the perception of the quality of fresh peaches by Spanish consumers. A theoretical model was created that explains quality using a set of intrinsic and extrinsic attributes. The information was from a survey of closed questions administered in person to a non-probabilistic sample of 192 Spanish consumers. The methodology used was structural equation modeling, with an analysis for goodness of fit using the indicators CMIN/ DF, RMR, NFI, RFI, RMSEA, and HOELTER. Thus, by adjusting the values recommended by the literature, a model was identified that explains the quality decisions of the consumers studied using two sets of attributes: intrinsic and extrinsic. Finally, significant and strong relationships were established between the perceived quality and the homogeneity of the fruit and between the perceived quality and the availability in supermarkets and fruit stores.
Molal Volumes of the Isotopic Homologs of Ethylene (1970)

The molal volumes of ethylene (C2H4), trans-dideuteroethylene (C2H2D2), and tetradeuteroethylene (C2D4) have been measured over the temperature range 105–175°K with a precision 10−2% (± 0.005cm3). The order of the molal volumes is VC2H4 &gt; VC2H2D2 &gt; VC2D4. The difference in molal volume between ethylene and each of its deutero derivatives is approximately 0.05 cm3 mol−1 per deuterium atom and decreases with temperature. The difference in molal volumes is compared with two limiting models. The “size effect” model, which is a consequence of the difference in lengths of the C–H and C–D bonds leads to the correct magnitude of the difference in molal volume, but predicts δV / V to be temperature independent for ethylene, contrary to the experimental findings. Calculations based on an anharmonic intermolecular potential show that the hindered rotation in liquid ethylene makes a significant contribution to the molal volume difference. Finally a correlation is made between the observed molal volume differences and the measured vapor-pressure differences of the deuteroethylenes.
Just how long can we live? (2000)

In June this year, United States President Clinton and British Prime Minister Blair jointly announced that the human genome had been sequenced. In another year or so, this information should be assembled into a much more useful form than that in which it now exists. The advances which will be made possible by the Human Genome Project and new genetic technologies may well extend the human life span still further.
Active Site Formation in WO<sub><i>x</i></sub> Supported on Spherical Silica Catalysts for Lewis Acid Transformation to Brønsted Acid Activity (2020)

The transformation of Lewis acid to new Brønsted acid upon hydrogen exposure of tungsten oxide supported on mesoporous spherical silica nanoparticles (SSP) catalysts has been investigated by in situ diffuse reflection infrared Fourier transform spectroscopy (DRIFTS) with adsorbed NH3. The principal goal of this work is to explore the influence of W species on the support and the activating processes involved in the formation of catalytically active sites for Lewis acid transformation. The samples were prepared by two preparation methods including incipient wetness impregnation and incorporation of W species to SSP support with the sol–gel method. Then, they were activated by N2 pretreatment compared with H2 before investigation. From the results of in situ DRIFTS experiments, the Lewis acid sites were changed to the Brønsted acid sites upon hydrogen exposure over activated catalysts. The abundance of tungstate W5+ species is found to facilitate the change of this acidity. In addition, the performance of Lewis acid transformation was correlated with tungstate W5+ active species, which could be more generated by activating process of H2 and N2 pretreatments. The impregnated W/SSP needs H2 pretreatment to activate active site formation, while the incorporated W-SSP can be activated in both of H2 and N2 pretreatments because the latter prefers the formation of tungstate W5+ species in catalyst, instead of W dispersed on SSP surface to form W surface structure characteristic of the W6+ species.
A message passing algorithm for compressed sensing in wireless random access networks (2013)

In this paper, we consider the joint multiuser detection and channel estimation problem in wireless random access networks which consists of a large number of users with a single antenna and a base station (BS) multiple antennas. We first convert the problem into the compressed sensing framework and then propose a message passing (MP) algorithm which reduces the implementation complexity at BS. Simulation results show that the performance of the proposed MP algorithm becomes improved as the number of antennas at BS.
Combined Volumetric and Surface Registration (2008)

In this paper, we propose a novel method for the registration of volumetric images of the brain that optimizes the alignment of both cortical and subcortical structures. In order to achieve this, relevant geometrical information is extracted from a surface-based morph and diffused into the volume using the Navier operator of elasticity, resulting in a volumetric warp that aligns cortical folding patterns. This warp field is then refined with an intensity driven optical flow procedure that registers noncortical regions, while preserving the cortical alignment. The result is a combined surface and volume morph (CVS) that accurately registers both cortical and subcortical regions, establishing a single coordinate system suitable for the entire brain.
High-efficiency cold-atom transport into a waveguide trap (2018)

Hollow-core optical fibers loaded with cold atoms show great promise as platforms for quantum information processing and highly nonlinear optics, but their limitations have remained poorly understood. Using detailed Monte Carlo simulation, the authors model the loading dynamics and predict the sensitivity of the system to various experimental parameters. Thus guided, they develop an experimental apparatus that can load an order of magnitude more atoms than usual, to yield the extremely high optical depths needed for high-efficiency quantum memories.
Lespace : un point de vue mathématique avec applications à lanalyse de la mobilité (2009)

Reference TRANSP-OR-TALK-2009-001 URL: http://transp-or2.epfl.ch/talks/CHOROS09.pdf Record created on 2009-06-15, modified on 2018-01-16
Transmission Channels Through Random Media (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Z. Shi, J. Wang, and A. Z. Genack, "Transmission Channels Through Random Media," in Frontiers in Optics 2011/Laser Science XXVII, OSA Technical Digest (Optica Publishing Group, 2011), paper FWF4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Treatment of chronic delta hepatitis with lamivudine <i>vs</i> lamivudine + interferon <i>vs</i> interferon (2008)

Chronic delta hepatitis is the most severe form of chronic viral hepatitis for which interferon (IFN) is the only available treatment. In 39 patients (25 were treatment-naïve, 14 had previously used IFN), efficacy of 1-year treatment with IFN (9 MU, t.i.w.) or lamivudine (LAM; 100 mg, q.d.) alone was compared with IFN and LAM combination (2 months of LAM to be followed by combination treatment). IFN monotherapy was given only to treatment-naïve patients. In both treatment-naïve and previous IFN users, end of treatment virological and biochemical responses were similar with IFN-LAM combination and superior to LAM monotherapy (P < 0.05). Improvement in liver histology occurred more often with IFN +/- LAM than with LAM alone (P < 0.05). In treatment-naïve patients, combination treatment was not superior to IFN monotherapy. After treatment discontinuation, virological and biochemical response rates decreased in LAM and IFN combination and IFN monotherapy. On treatment virological response at month 6 of treatment predicted sustained virological response. The results of this study suggest that addition of LAM to IFN for the treatment of delta hepatitis is of no additional value and that both treatment modalities are superior to LAM monotherapy.
COHERENT STRUCTURE AND FORMATION MECHANISM OF SECONDARY FLOW IN TURBULENT OPEN CHANNEL FLOW IN CORNERS (2001)

側壁領域の水表面部に横断面視, 水平断面視, また二象限同時可視化を適用することにより, 水表面部に形成される組織構造の特徴を考察した. この組織構造は, 側壁に形成された壁縦渦が水表面へ発達し, そこからその片側の渦はさらに水表面に沿って水路中央へ発達する準周期的な渦構造であり, この渦構造は, 河岸ボイルの形成に重要な役割を演じている. この水表面部の組織構造とこれまで明らかにした隅角部の組織構造が誘起する瞬時の二次流れの特徴について, 流れの可視化とPTVを同時に行なうことの可能なDPTVを横断面視に用いて検討を行ない, 水表面に形成する渦構造は側壁方向へ向かう瞬時の二次流れとボイルを誘起すること, 隅角部に形成される壁縦渦構造が隅角に向かう瞬時の二次流れを形成することを明らかにし, 長時間平均像の二次流れの形成機構について言及した.
Spiropyran salts and their neutral precursors: synthesis, crystal structure, photochromic transformations in solutions and solid state (2015)

Abstract This review covers investigations of spiropyran iodides with N-substituted indoline fragment, and with the pyran cycle being annelated to N-methylated pyridine ring. The schemes of synthesis of iodides and their neutral precursors, as well as results of X-ray analysis and photochemical study of the crystals of the obtained compounds are presented. Based on our and literature data, the relationship between the structure and photochromic properties has been discussed for a series of salts and neutral pyridospiropyrans.
ChemInform Abstract: Lithiation and Functionalization of 1‐Alkynylimidazoles at the 2‐Position. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.