gebhart/patrepeval huggingface dataset:
Elevated Lymphocyte ATP‐ase Activity in Patients with Cancer of the Uterine Cervix (1975)

Elevated lymphocyte Adenosine Tri-Phosphatase (ATP-ase) activity was found in 23 och 28 patients with cervical uterine carcinomas of various stages. Treatment with external irradiation and radium insertion was followed by a decline in the lymphocyte ATP-ase activity in 22 patients, while the activity remained unchanged in one patient. No correlation between the tumour stage and the lymphocyte ATP-ase activity was demonstrated. In 24 patients the clinical effect of the treatment was well correlated with the decline in ATP-ase activity. It is suggested that the determination of lymphocyte ATP-ase activity could be valuable in screening for cervical carcinoma and for follow-up after radical treatment.
Two new hemoglobins. Hemoglobin Alabama (beta39(C5)Gln leads to Lys) and hemoglobin Montgomery (alpha 48(CD 6) Leu leads to Arg). (1975)

The amino acid substitutions in two new hemoglobins found by electrophoretic screening during a survey in Alabama have been determined by column chromatography and amino acid analyses of their tryptic peptides. They are hemoglobin Alabama (beta 39(C 5)Gln leads to Lys) and hemoglobin Montgomery (alpha 48(CD 6) Leu leads to Arg). No harmful symptoms have been attributed to the presence of either hemoglobin.
Hesperidin as a preventive resistance agent in MCF–7 breast cancer cells line resistance to doxorubicin (2014)

Hesperidin has cytotoxic effect on MCF-7/Dox cells with IC50 of 11 µmol/L. Hesperidin did not increased the apoptotic induction combined with doxorubicin. Co-chemotherapy application of doxorubicin and hesperidin on MCF-7/Dox cells showed synergism effect through inhibition of Pgp expression.
Novel Electrical Continuously Variable Transmission System and its Numerical Model (2014)

A novel electrical continuously variable transmission (E-CVT) system for hybrid electric vehicles is presented. The merits of the system, which is comprised of a magnetic gear (MG) integrated permanent magnet brushless machine, are its compactness, light weight, very high torque density, and simple structure. The integrated MG is ingeniously used to greatly amplify its output torque. It serves the functions of both power splitting and coupling. The drawbacks of mechanical gears or brushes in traditional systems are overcome. A design method based on finite element method for maximizing the torque output of the machine is presented and the performance of the machine in the E-CVT system is validated.
Epidermal‐growth‐factor receptor correlates negatively with cell density in cervical squamous epithelium and is down‐regulated in cancers of the human uterus (1998)

The role of the epidermal-growth-factor receptor (EGFR) in cervical cancer is controversial, due to technical difficulties in localizing or in quantifying EGFR by homogenate assays or immunohistochemistry. Our autoradiographic approach, in combination with morphometry, allowed cell-type-specific quantification of EGFR, leading to the following observations: (i) In normal cervical epithelium, EGFR levels per cell were high in non-dividing squamous cells of the upper layers of normal epithelium, where a mitogenic function of these EGFRs can be excluded. (ii) In contrast to earlier findings in tissue homogenates, but consistent with our observation in normal cervical epithelium that cells of the proliferating strata (basal and parabasal cells) express intermediate and comparatively reduced levels of EGFR per cell, cervical cancers displayed a significant reduction both of specific EGF binding and of EGFR levels per cell as compared with normal epithelium. (iii) A significant negative correlation of cell density and EGFR number per cell was obtained. In normal cervical epithelium, cervical intra-epithelial neoplasia and invasive cervical cancer (p 0.002). This negative correlation was most evident in normal epithelium, where large changes of cell density occur within one slide (p F 0.001). (iv) Specific EGF-binding was also significantly reduced in endometrial cancers when compared with normal endometrium. It is proposed that in uterine tissues low or intermediate levels of EGFR do not exclude their function as mediators of cell proliferation.
Radial shear interferometry (1962)

Radial shear interferometry, in which a wave front is compared with an expanded image of itself, is described and a relation between wave-front aberration and interference pattern derived. Two interferometers are described, one for small radial shears, and an `exploded shear' type where the expansion is very large. This latter instrument is direct reading in that the wave-front aberrations appear unmodified in the interference pattern.
Electrostatic servo system for multi-axis accelerometers (2002)

A multi-axis capacitive accelerometer, using an electrostatic servo system was developed. In this system, an acceleration in three axes (X,Y,Z) is decomposed into its axial components independently and simultaneously by using the synchronous demodulation. The problem of off-axis response was solved by using the electrostatic force balancing to keep the seismic mass in the original position. Typical results achieved for off-axis sensitivity were 1.3-7.3%.
Engineering cyanobacteria to improve photosynthetic production of alka(e)nes (2013)

The extent of alka(e)ne production could correlate positively with the expression level of alkane biosynthetic genes. Redirecting the carbon flux to acyl-ACP and overexpressing alkane biosynthetic genes simultaneously can enhance alka(e)ne production in cyanobacteria effectively.
Molecular species of phospholipids of Lilium longiflorum pollen. (1990)

Molecular species of the major phospholipids, phosphatidylcholine (PC, 49 %of total phospholipids), phosphatidylethanolamine (PE, 27 %), and phosphatidylinositol (PI, ll %), of Lilium longiflorum pollen grains were analyzed. Fatty acid compositions (sn-l/sn-l) of major molecular species of PC, PE, and PI were 18:3/18:3, 18:2/18:3 (and/or 18:3/18:2), 18:2/18:2, 16:0/18:3, and 16:0/18:2.
The Comparison of Gene Expression from Multiple cDNA Libraries (2000)

We describe a method for comparing the abundance of gene transcripts in cDNA libraries. This method allows for the comparison of gene expression in any number of libraries, in a single statistical analysis, to identify differentially expressed genes. Such genes may be of potential biological or pharmaceutical relevance. The formula that we derive is essentially the entropy of a partitioning of genes among cDNA libraries. This work goes beyond previously published analyses, which can either compare only two libraries, or identify a single outlier in a group of libraries. This work also addresses the problem of false positives associated with repeating the test on many thousands of genes. A randomization procedure is described that provides a quantitative measure of the degree of belief in the results; the results are further verified by considering a theoretically derived large deviations rate for the test statistic. As an example, the analysis is applied to four prostate cancer libraries from the Cancer Genome Anatomy Project. The analysis identifies biologically relevant genes that are differentially expressed in the different tumor cell types.
Future trends in SoC interconnect (2005)

Self-timed packet-switched networks are poised to take a major role in addressing the complex system design and timing closure problems of future complex systems-on-chip. The robust, correct-by-construction characteristics of self-timed communications enables each IP block on the SoC to operate in its own isolated timing domain, greatly simplifying the problems of timing verification. Design automation software can remove the need for expertise in self-timed design, enabling the on-chip interconnect to be treated as an additional IP block within a conventional (synchronous) design flow. The paradigm shift from viewing the SoC design problem as a matter of organizing complex hierarchies of buses with multiple coupled timing domains, where every interface between timing domains must be verified carefully, to viewing the SoC as a problem in network design where those timing issues are automatically isolated, promises significant improvements in designer productivity, component reuse and SoC functionality.
The Effect of Carbon Monoxide on Humans (1975)

This review critiques the scientific literature reporting the effects of carbon monox­ ide (CO) upon humans, examining those exposure situations that result in blood saturation of carboxyhemoglobin (COHb) below 18%, saturations which generally do not result in signs or symptoms of overt intoxication. A reappraisal of the CO literature is desirable for several reasons: 1. A recently reported national survey disclosed that 45% of the nonsmoking blood donors in 18 sections of the country, each one of which included metropolitan and rural areas, had COHb saturations greater than 1.5%, which indicated that exposure to CO in' excess of that permitted by the quality standards of the Clean Air Act of 1971 was widespread and occurring regularly (1-3). If the air quality standard for CO is judged to be scientifically sound, the decision not to enforce it but to relax the standard because of the national energy crisis could place the health of some citizenry in jeopardy. 2. A series of air quality standards for CO for various civilian populations, indus­ trial operations, and special military groups has been promulgated (Appendix A). In several instances these have been based upon scientific observations currently held to be of questionable validity. 3. The administration of certain drugs has been observed to accelerate the catabol­ ism of hepatic heme, doubling the endogenous CO production (4-6). In certain individuals with compromised cardiovascular systems, such an increase could pose a significant toxic stress. 4. Diseases manifesting increased hemolysis feature elevated COHb saturations that could be toxic to individuals with already compromised cardiovascular systems (7). This literature review itemizes the expected and unexpected source� elf CO, summarizes the basic pathophysiology of the gas, and then scrutinizes the effects of CO on human cognitive performance and cardiovascular system.
Efficacy of tamoxifen as treatment of breast cancer. (1997)

The synthetic antiestrogen tamoxifen was developed by ICI Pharmaceuticals (now Zeneca) in 1969 as a possible oral contraceptive and later was shown in clinical trials to be an effective treatment against advanced breast cancer. Since that time, millions of women have received tamoxifen as therapy for metastatic breast cancer as well as adjuvant treatment following surgery for primary breast cancer. Based on the data evaluated to date, adjuvant tamoxifen treatment for 2 to 5 years following primary treatment is associated with a 30% reduction in the odds of recurrence and a 20% reduction in the odds of death each year for at least 10 years. In addition, data from studies suggest that tamoxifen could have a small possibly beneficial effect on noncancer mortality.
DVB-T Signal Ambiguity Function Control for Passive Radars (2014)

The use of digital video broadcasting-terrestrial (DVB-T) signals as waveform of opportunity for passive coherent location (PCL) is addressed here. The ambiguity function (AF) of the considered waveform of opportunity has been shown to yield regularly spaced undesired peaks which might strongly limit the target detection capability of a DVB-based PCL system. A new technique for DVB-T AF control is proposed, able to overcome the limitations of previously proposed approaches in terms of achievable performance, system requirements, and computational burden. The performance analysis against simulated and real data shows that the proposed technique yields an effective removal of the undesired peaks in the AF thus making the considered waveform more attractive for PCL surveillance.
Comparison between three-dimensional speckle-tracking echocardiography and cardiac magnetic resonance imaging for quantification of left ventricular volumes and function (2012)

Although 3DSTE-derived LV volumes are underestimated in most patients compared with MRI, measurement of the LVEF revealed excellent accuracy. Measurements of CS were systematically greater (i.e. more negative) with 3DSTE than MRI, which likely reflects various inter-technique differences that preclude direct comparability of their measurements.
E-Books and New Library Service Models: An Analysis of the Impact of EBook Technology on Academic Libraries (2001)

Effectively introducing e-books into a library has significant implications on our users, our existing services, and how we do business. The capabilities and the limitations of the e-book and related technologies are therefore used in this paper to provide a framework for examining the implications of this technology on service in academic libraries. It is the author’s view that we must understand not only the technology but also the end-to-end process that will transform the capabilities of the technology into an effective service.
X-CSR: Dataflow Optimization for Distributed XML Process Pipelines (2009)

XML process networks are a simple, yet powerful programming paradigm for loosely coupled, coarse-grained dataflow applications such as data-centric scientific workflows. We describe a framework called Delta-XML that is well-suited for applications in which pipelines of data processors modify parts (deltas'') of XML data collections while keeping the overall collection structure intact. We show how to optimize the execution of Delta-XML process networks by minimizing the data shipping cost in distributed settings. This X-CSR** optimization employs static type inference based on XML Schema to determine the XML stream fragments that are relevant to a processor, allowing irrelevant fragments to be bypassed (shipped'') to downstream pipeline steps. Finally, we present evaluation results for a real-world scientific workflow, which shows the practical feasibility of X-CSR. A long version of this paper is available as technical report (http://www.cs.ucdavis.edu/research/tech-reports/2008/CSE-2008-15.pdf).** X-CSR: _X_ML _C_ut, _S_hip, and _R_eassemble; pronounced X-scissor''
Deep Echo State Network (DeepESN): A Brief Survey (2017)

The study of deep recurrent neural networks (RNNs) and, in particular, of deep Reservoir Computing (RC) is gaining an increasing research attention in the neural networks community. The recently introduced Deep Echo State Network (DeepESN) model opened the way to an extremely efficient approach for designing deep neural networks for temporal data. At the same time, the study of DeepESNs allowed to shed light on the intrinsic properties of state dynamics developed by hierarchical compositions of recurrent layers, i.e. on the bias of depth in RNNs architectural design. In this paper, we summarize the advancements in the development, analysis and applications of DeepESNs.
Very high pressure behavior of precisely-poled PVDF (1995)

Abstract Ferroelectric polymers with well defined and precisely known electrical properties are now routinely available from commercial sources. Electrical processing with the Bauer cyclic poling method can routinely produce individual samples with a range of remanent polarizations up to 9 μC/cm2. Such well defined samples provide an unusual opportunity to carry out experiments which study the structure and physical properties of the materials. In the present case, the behavior of PVDF has been studied over a wide range of pressures with the destructive, but precise, method of very-high-pressure shock loading. The method of loading provides accuracy and precision of pressure of about 1%. In studies to 10 GPa, the nonlinear piezoelectric behavior of PVDF is carefully studied. Studies to pressures of 30 GPa are available which show that the piezoelectric behavior is linearly dependent on volume compression to a close approximation.
Airy disk diffraction pattern: comparison of some values of f/No and obscuration ratio (1986)

The radii of the first three zeros and secondary maxima of the Airy disk diffraction pattern and the smallest radius for which the encircled energy is >90% are calculated for several values of f/No. and obscuration ratio. Formulas giving these radii as a function of the f/No. are also given.
Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis (2015)

Epigenetic mechanisms that regulate endothelial cell gene expression are now emerging. DNA methylation is the most stable epigenetic mark that confers persisting changes in gene expression. Not only is DNA methylation important in rendering cell identity by regulating cell type-specific gene expression throughout differentiation, but it is becoming clear that DNA methylation also plays a key role in maintaining endothelial cell homeostasis and in vascular disease development. Disturbed blood flow causes atherosclerosis, whereas stable flow protects against it by differentially regulating gene expression in endothelial cells. Recently, we and others have shown that flow-dependent gene expression and atherosclerosis development are regulated by mechanisms dependent on DNA methyltransferases (1 and 3A). Disturbed blood flow upregulates DNA methyltransferase expression both in vitro and in vivo, which leads to genome-wide DNA methylation alterations and global gene expression changes in a DNA methyltransferase-dependent manner. These studies revealed several mechanosensitive genes, such as HoxA5, Klf3, and Klf4, whose promoters were hypermethylated by disturbed blood flow, but rescued by DNA methyltransferases inhibitors such as 5Aza-2-deoxycytidine. These findings provide new insight into the mechanism by which flow controls epigenomic DNA methylation patterns, which in turn alters endothelial gene expression, regulates vascular biology, and modulates atherosclerosis development.
TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration (2014)

Lack of a preclinical model of primary dystonia that exhibits dystonic-like twisting movements has stymied identification of the cellular and molecular underpinnings of the disease. The classical familial form of primary dystonia is caused by the DYT1 (ΔE) mutation in TOR1A, which encodes torsinA, AAA⁺ ATPase resident in the lumen of the endoplasmic reticular/nuclear envelope. Here, we found that conditional deletion of Tor1a in the CNS (nestin-Cre Tor1a(flox/-)) or isolated CNS expression of DYT1 mutant torsinA (nestin-Cre Tor1a(flox/ΔE)) causes striking abnormal twisting movements. These animals developed perinuclear accumulation of ubiquitin and the E3 ubiquitin ligase HRD1 in discrete sensorimotor regions, followed by neurodegeneration that was substantially milder in nestin-Cre Tor1a(flox/ΔE) compared with nestin-Cre Tor1a(flox/-) animals. Similar to the neurodevelopmental onset of DYT1 dystonia in humans, the behavioral and histopathological abnormalities emerged and became fixed during CNS maturation in the murine models. Our results establish a genetic model of primary dystonia that is overtly symptomatic, and link torsinA hypofunction to neurodegeneration and abnormal twisting movements. These findings provide a cellular and molecular framework for how impaired torsinA function selectively disrupts neural circuits and raise the possibility that discrete foci of neurodegeneration may contribute to the pathogenesis of DYT1 dystonia.
An Efficient Approach for the Calibration of Multiple PTZ Cameras (2007)

In this paper, we propose an efficient approach to infer the relative positioning and orientation among multiple pan-tilt-zoom (PTZ) cameras. In this approach, the tilt angle and altitude of each PTZ camera are estimated first based on the observation of some simple objects lying on a horizontal plane. With the estimated tilt angles and altitudes, the calibration of multiple cameras can be easily accomplished by comparing the back-projected world coordinates of some common vectors in 3-D space. This calibration method does not require particular system setup or specific calibration patterns. The sensitivity analysis with respect to parameter fluctuations and measurement errors is also discussed. Experiment results over real images have demonstrated the efficiency and feasibility of this approach. Note to Practitioners-This paper was motivated by the problem that pan-tilt-zoom (PTZ) cameras may change their poses from time to time to achieve better monitoring results. Whenever there is a change, we need to recalibrate the extrinsic parameters again. In this paper, we demonstrate a new and efficient approach to calibrate multiple PTZ cameras. The concept of our approach originated from the observation that people could usually make a rough estimate about the tilt angle of the camera simply based on some clues revealed in the captured images. Based on our approach, we can simply use some A4 papers on a table to calibrate multiple PTZ cameras. In our approach, there is no need to calculate the commonly used homography matrix. For real cases, once a set of PTZ cameras is settled, we can simply place a few simple patterns on a horizontal plane. These patterns can be A4 papers, books, boxes, etc.; and the horizontal plane can be a tabletop or the ground plane. The whole procedure does not need specially designed calibration patterns and requires only a light computational load. In the near future, we will work on the extension of the proposed approach so that we will be able to perform dynamic calibration when the PTZ cameras are under movement
FDTD analysis of a non-invasive sensor for the detection of breast tumours (2002)

The detection of breast cancer at an early stage is of vital importance if the high mortality rate from this disease is to be reduced. At present the most widely used imaging technique for the detection of breast tumours is mammography, however, a major disadvantage of this method is that it uses ionising radiation. There is therefore a need for complementary techniques which use non-ionising radiation, for example microwaves. Here the authors present results for a non-invasive imaging system which is currently being used to explore the feasibility of microwave imaging as a method of detecting breast tumours. The authors' purpose is to present a clear description of the theoretical model of the microwave sensor and to demonstrate the techniques used to match experimental measurements and calculated data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Signals in a cell uptake of aluminum injection with the as-i bus (2011)

Peer Reviewed
The Southwest Historical Series: Historical Documents, Hitherto Unpublished or Inaccessible, Depicting Social and Economic Conditions in the Southwest during the Nineteenth Century (1943)

Journal Article The Southwest Historical Series: Historical documents, hitherto unpublished or inaccessible, depicting social and economic conditions in the Southwest during the Nineteenth Century. Edited with Historical and Geographical additions, Introductions and Analytical Index Get access George P. Hammond George P. Hammond University of New Mexico Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 30, Issue 2, September 1943, Pages 269–270, https://doi.org/10.2307/1892989 Published: 01 September 1943
Modern ECT: Effective<i>and</i>safe (1984)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Hepatitis B virus infection and hypermethylation of anti-oncogene promoters (2008)

It has been widely reported that HBV infection can lead to hypermethylation of anti-oncogene promoters.This review summarizes the recent studies and new mechanisms of HBV-associated hypermethylation of anti-oncogenes in vitro and vivo.