gebhart/patrepeval huggingface dataset:
Wastes and by-products - alternatives for agricultural use (1994)

In the neonatal intensive care units (NICU), epicutaneo-caval catheters (ECCs) are common alternative vascular routes. Pericardial effusion (PCE) and cardiac tamponade (CT) are rare but serious complications in infants with ECCs. It may be asymptomatic or present with a variety of significant clinical signs, including dyspnea, bradycardia, sudden asystole, and hypotension. If untreated, PCE can be fatal. This report presents, three cases of ECC-associated PCE/CT during NICU stay. All three patients were born before 30 weeks of gestation and weighed less than 1500 g. Echocardiography was used for diagnosis all patients. PCE/CT was detected incidentally in one patient and after hemodynamic deterioration in the other two. In one patient, CT was developed due to catheter malposition, and the other two patient, the catheter tip was found in the right atrium. PCE did not recur in any of the patients after pericardial fluid was drained and the catheters were removed. No PCE/CT-related deaths were observed. In all three patients, X-ray was used to evaluate the location of the catheter tips. However, after clinical deterioration, echocardiography showed that in the first two cases the tips were actually in the right atrium. Real-time ultrasound was suggested with strong evidence to evaluate the location of the catheter tip and to detect secondary malapposition. PCE/CT should be considered in the presence of unexplained and refractory respiratory distress, abnormal heart rate and blood pressure, and metabolic acidosis in a neonate with ECC. Early diagnosis and prompt pericardiocentesis are essential to reduce mortality and improve prognosis. Prospective studies with educational interventions should be designed to demonstrate that the use of point-of-care ultrasound (POCUS) can be easily acquired and may reduce complications.
Zinc Phytoextraction in<i>Thlaspi caerulescens</i> (2001)

ABSTRACT The existence of metal hyperaccumulator species demonstrates that plants have the genetic potential to remove toxic metals from contaminated soil. Possibly, one of the best-known hyperaccumulators is Thlaspi caerulescens. This species has been shown to accumulate very high Zn concentrations without manifesting any sign of toxicity. Thus, T. caerulescens represents an excellent experimental system for studying metal hyperaccumulation in plants as it relates to phytoremediation. In this article, we review the results of an investigation into the physiology, biochemistry, and molecular regulation of Zn transport and accumulation in T. caerulescens compared with a nonaccumulator relative T. arvense. Physiological studies focused on the use of 65Zn radiotracer flux techniques to characterize zinc transport and compartmentation in the root, and translocation to the shoot. Transport studies indicated that a number of Zn transport sites were stimulated in T. caerulescens, contributing to the hyperaccumulation trait. Thus, Zn influx into root and leaf cells, and Zn loading into the xylem was greater in T. caerulescens compared with the nonaccumulator T. arvense. The 4.5-fold stimulation of Zn influx into the roots of T. caerulescens was hypothesized to be due to an overexpression of Zn transporters in this species. Additionally, compartmental analysis (radiotracer wash out or efflux techniques) was used to show that Zn was sequestered in the root vacuole of T. arvense inhibiting Zn translocation to the shoot in this nonaccumulator species. Molecular studies focused on the cloning and characterization of Zn transport genes in T. caerulescens. Functional complementation of a yeast Zn transport-defective mutant with a T. caerulescens cDNA library constructed in a yeast expression vector resulted in the cloning of a Zn transport cDNA, ZNT1. Expression of ZNT1 in yeast allowed for a physiological characterization of this transporter. ZNT1 was shown to encode a high-affinity Zn transporter that can also mediate low-affinity Cd transport. Biochemical analyses indicated that enhanced Zn transport in T. caerulescens results from a constitutively high expression of ZNT1 in roots and shoots. These results suggest that overexpression of ZNT1 may be linked to an alteration of the Zn tolerance mechanism in this species.
The molecular ZPA (1998)

Signals that instruct the developing limb bud mesenchyme to form the appropriate elements along the anterior posterior axis emanate from the zone of polarizing activity (ZPA). Studies of the last five years have illustrated that the Sonic hedgehog (Shh) protein mediates the activities of the ZPA. This review will focus on three aspects of the ZPA biology. We will address induction of the ZPA in terms of the factors required for activation and maintenance of Shh expression in the posterior limb bud mesenchyme and the evidence for negative regulatory mechanisms that prevent inappropriate Shh expression. Second, we will discuss the current understanding of Shh processing and transduction of the Shh signal, inferring much from the elegant studies on Drosophila Hedgehog (Hh) protein. Finally, we will address the interpretation of the secreted Shh signal by the limb bud mesenchyme that leads to a predictable morphological response.
Identification of Genes Potentially Involved in Disease Transformation of CML. (2004)

Abstract In patients with chronic myeloid leukemia who do not reach a (near) complete cytogenetic response upon treatment, the disease progresses over months to several years from an indolent, chronic phase into a rapidly fatal blast crisis. Events that are responsible for this transformation process are largely unknown. To identify changes occurring in the course of the disease, we performed cDNA subtraction on sequentially stored peripheral blood mononuclear cell pellets, collected from a single CML patient throughout the course of disease. Thirty-three differentially expressed sequences were identified, of which 28 corresponded to known genes. Quantitative PCR confirmed cDNA subtraction results for 24 of 25 tested genes. Differential expression levels ranged from <2- to 106-fold. The sequences that were identified include genes encoding for several apoptosis related proteins, cell cycle proteins, interleukins/chemokines, heat shock proteins and a DNA repair enzyme (see table). Thus far, expression levels of eight genes have been tested in sequential samples of three to six additional CML patients, gathered throughout their disease course. PBCEF, IL8, IL6, CCL4 and YWHAZ show comparable patterns as the index patient; expression levels of APEX, NXF1 and PRG1 were consistent with those of the index patient in only a part of the additional patients. More patients are being tested on these and remaining genes. We conclude that this set of genes can be considered as a valuable starting point for further research on the causes of disease transformation in CML. Name of gene Accession No. Fold difference (Q-PCR) * Genes hypothetically encoding proteins, ** Reverse to subtraction result, ***orf: open reading frame diagnosis > blast crisis: PRG1 NM_002727 14 IVNS1ABP NM_006469 <2 MPO NM_000250 ND blast crisis > diagnosis: EMR1 NM_001974 <2 CD96 NM_198196 3 GAS2 NM_005256 12 CHI3L2 NM_004000 11 late chronic phase > blast crisis: IL8 NM_000584 2 S100A8 NM_002964 16 FPR1 NM_002029 51 LYZ NM_000239 ND MEN1 AF001893 ** blast crisis > late chronic phase: MMRN NM_007351 6 NACSIN NM_015252 24 LARS NM_020117 7 FLJ25286* NM_152546 ND C5orf13*** NM_004772 ND C15orf15*** NM_016304 ND FLJ10849* NM_018243 ND diagnosis > late chronic phase: DNAJB1 NM_006145 35 HSPA8 NM_006597 5 NXF1 NM_006362 2 DC2 NM_021227 <2 APEX1 NM_080648 4 RPS6 NM_001010 <2 EEF1A1 NM_001402 3 FLJ25286* NM_152546 ND late chronic phase > diagnosis: SAT NM_002970 7 CCL4 NM_002984 106 YWHAZ NM_145690 3 PBEF1 NM_182790 7 IL6 NM_000600 42 IL8 NM_000584 9
Utilisation de la Propagation de Contraintes Booléennes pour la Production de Sous-Clauses (2005)

http://www710.univ-lyon1.fr/~csolnon
The interaction of oligo(ethylene oxide) with water: a quantum mechanical study (2000)

Using density functional theory with nonlocal corrections we have performed a systematic study of the molecular conformation and energetics of methoxy terminated oligo(ethylene oxide) (EG)n molecules. For n=3 we have calculated 31 conformers without and with adsorbed water, and made some comparisons with n=1, 2 and selected n=4 conformers. We find that solvated EG moieties with non-uniform gauche rotations are by far the most stable in the solvated state. We also examine rotational barriers around the C–O and C–C bonds. In addition, using the calculated energies and vibrational spectra of the dry and solvated EG strands and the tabulated thermodymamical functions of water we can estimate the enthalpy and entropy contribution to the free energy of solvation.
An experimental investigation of turbine rotor wakes for the development of a fiber optic pressure sensor (1990)

Hostile environments and aggressive performance requirements associated with future gas turbine engines has required the development of fiber optic sensors. A fiber optic pressure sensor (FOPS) is being developed to detect turbine rotor speed by counting rotor blade passage through detection of rotor blade wakes in the exit flow field. The FOPS pressure tube, which protrudes into the flow path, transfers the unsteady pressure signal from the flow path to the sensor diaphragm mounted on the turbine shroud. Three phases of the FOPS development are described herein. These include an experimental investigation of an unsteady turbine exit flow field, a pressure tube optimization study, and a validation of the fiber optic pressure sensor in a component test turbine. The turbine rotor exit flow field unsteady pressure data indicate rotor wakes can be detected by the fiber optic pressure sensor over a wide range of turbine operating conditions. The flow path location and design of the FOPS pressure tube was shown to be critical in optimizing the sensor performance.
The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV‐1 reverse transcriptase bypass of an abasic site with deoxy‐, dideoxy‐, and ribonucleotides (2007)

Abasic (AP) sites pose a potential danger to HIV-1 replication. HIV-1 RT has been shown to preferentially incorporate purines opposite an AP site, and subsequently extend from the lesion. While it is clear that AP sites are bypassed inefficiently and are major sites of RT pausing, detailed kinetic analysis of the relative contributions of both the incorporation and the pyrophosphorolytic reactions in translesion synthesis by HIV-RT is still lacking. Investigation of the molecular basis of these processes is important, in light of the fact that HIV-1 RT is the major target for anti-HIV chemotherapy, and its low fidelity is an essential determinant of the extraordinary genetic variability of HIV-1, which is important for the appearance of mutant viruses resistant to chemotherapy. Here, we analyzed the effects of the presence of an AP site on the template strand on the catalytic properties of the DNA-dependent polymerization reaction as well as on the phosphorolytic activity of HIV-1 RT, in the presence of deoxy-, dideoxy,- and ribonucleotides. We find that AP sites can substantially influence the substrate specificity of HIV-1 RT and that pyrophosphorolysis plays a significant role in determining the ability of HIV-1 RT to (mis)incorporate nucleotides.
CdS/CdSe/CdS spherical quantum wells as single-photon sources (2021)

We have synthesized CdS(1.3 nm)/CdSe(1.7 nm)/CdS(3.4 nm) spherical quantum wells with 13 nm diameter and demonstrated the first antibunching of their emission, labelling them as single-photon sources. Antibunching survives even at high excitation intensities, ruling-out bi-exciton emission. For the largest intensities, antibunching coupled to spectral measurements, reveal the signature of a blue-shifted emission, associated to an irreversible photo-aging effect. We demonstrate a moderate correlation between the main and the blue-shifted emission energy. Intensity-timetraces show low-blinking, with a median time spent in the bright state of 89 %. Emission lifetime measurements reveal a complex emission dynamic with either three or four components. While spherical quantum wells have been initially designed for laser-oriented applications, we demonstrate that they can serve as single-photon sources.
Investigation of a Possible Interaction Between Quetiapine and Armodafinil in Patients With Schizophrenia: An Open‐Label, Multiple‐Dose Study (2011)

The wakefulness-promoting medication armodafinil (R-modafinil) is being studied as an adjunctive treatment for patients with schizophrenia receiving antipsychotic therapy. This open-label study in 37 adults with schizophrenia evaluated whether a drug-drug interaction occurs between armodafinil (a moderate CYP3A4 inducer) and the atypical antipsychotic quetiapine (primarily metabolized by CYP3A4). Patients were required to be on a stable dose of quetiapine ≥300 mg once daily in the evening before enrollment. Steady-state quetiapine pharmacokinetics were determined following daily administration of quetiapine alone in the evening (day 5) and then following concomitant armodafinil administration (titrated to 250 mg) daily in the morning (day 38). In 25 evaluable patients, concomitant armodafinil resulted in a statistically significant decrease in mean AUC(0-24) and C(max) values of quetiapine by 42% and 45%, respectively, versus quetiapine alone. Adverse events occurred more frequently with combination therapy and were consistent with the known profiles of the 2 drugs. No significant changes in mean PANSS negative, positive, and total scores or SANS scores were observed. Although the data do not suggest that the observed decrease in systemic exposure to quetiapine was associated with a change in disease state, patients with schizophrenia should be monitored during combination therapy with quetiapine and armodafinil.
Spectra and energy levels of Cu xxii, Cu xxiii, Cu xxiv, and Cu xxv (1987)

Transitions in highly ionized copper in the wavelength range 65–121 Å have been identified in spectra recorded at the University of Rochester’s 24-beam Omega laser facility. Wavelengths and energy levels are presented for oxygenlike Cu xxii, nitrogenlike Cu xxiii, carbonlike Cu xxiv, and boronlike Cu xxv. The wavelengths of magnetic dipole transitions within the ground configurations are predicted from the energy levels.
Auditory Stimuli Mimicking Ambient Sounds Drive Temporal “Delta-Brushes” in Premature Infants (2013)

In the premature infant, somatosensory and visual stimuli trigger an immature electroencephalographic (EEG) pattern, "delta-brushes," in the corresponding sensory cortical areas. Whether auditory stimuli evoke delta-brushes in the premature auditory cortex has not been reported. Here, responses to auditory stimuli were studied in 46 premature infants without neurologic risk aged 31 to 38 postmenstrual weeks (PMW) during routine EEG recording. Stimuli consisted of either low-volume technogenic "clicks" near the background noise level of the neonatal care unit, or a human voice at conversational sound level. Stimuli were administrated pseudo-randomly during quiet and active sleep. In another protocol, the cortical response to a composite stimulus ("click" and voice) was manually triggered during EEG hypoactive periods of quiet sleep. Cortical responses were analyzed by event detection, power frequency analysis and stimulus locked averaging. Before 34 PMW, both voice and "click" stimuli evoked cortical responses with similar frequency-power topographic characteristics, namely a temporal negative slow-wave and rapid oscillations similar to spontaneous delta-brushes. Responses to composite stimuli also showed a maximal frequency-power increase in temporal areas before 35 PMW. From 34 PMW the topography of responses in quiet sleep was different for "click" and voice stimuli: responses to "clicks" became diffuse but responses to voice remained limited to temporal areas. After the age of 35 PMW auditory evoked delta-brushes progressively disappeared and were replaced by a low amplitude response in the same location. Our data show that auditory stimuli mimicking ambient sounds efficiently evoke delta-brushes in temporal areas in the premature infant before 35 PMW. Along with findings in other sensory modalities (visual and somatosensory), these findings suggest that sensory driven delta-brushes represent a ubiquitous feature of the human sensory cortex during fetal stages and provide a potential test of functional cortical maturation during fetal development.
Structural Slot Tension Spacers: the Key for Silent Electrical Machines (2001)

Vol. 1, pp. 33-39
Low-temperature formation of device-quality SiO2/Si interfaces by a two-step remote plasma-assisted oxidation/deposition process (1992)

This article describes a new approach to the low-temperature (200–300 °C) formation of electronic-quality SiO2/Si heterostructures in which the steps of interface formation and bulk oxide deposition are separately controlled to optimize the electronic properties of the resulting device structure. This approach combines an in vacuo cleaning/passivation step for removal of residual C-atom surface contamination with a passivation of the Si surface by an ultrathin oxide layer, ∼0.5 nm, and then completes the SiO2/Si heterostructure with a plasma-assisted deposition of the SiO2 thin film. The new process differs both qualitatively and quantitatively from conventional high-temperature, ∼850–1000 °C, thermal, or rapid thermal oxidation in which interface formation and oxide film growth are accomplished at the same time through a continuous consumption of the Si substrate.
Basal Cell Skin Cancer after Total-Body Irradiation and Hematopoietic Cell Transplantation (2009)

Previous studies identified radiation therapy as a key modifier of basal cell carcinoma (BCC) risk in survivors of hematopoietic cell transplantation (HCT). In the present analysis, risk of BCC was analyzed in relation to age at transplant, attained age, race, total-body irradiation (TBI), and radiation fractionation in 6,306 patients who received HCT at ages 0-65 years after conditioning regimens with (n = 3870) or without (n = 2436) TBI, and who were followed from 100 days to 36.2 years after HCT. While age-specific BCC rates in the unirradiated patient population were higher than those reported for two non-patient populations, the general characteristics were similar; rates increased with attained age, were eightfold lower for non-white patients, and were higher in more recent birth cohorts. After adjusting for these effects, risk in unirradiated patients did not vary significantly with age at HCT. The additional BCC risk associated with radiation exposure was largest for the youngest ages at exposure to radiation, with relative risks exceeding 20 for those transplanted at ages less than 10 years, and decreased with increasing age at exposure until age 40 years, above which no excess risk was identified. Relative risk in the irradiated population did not vary significantly with attained age, dose fractionation or race. Risks per unit dose in HCT patients were similar to other populations exposed under clinical settings to similar radiation doses and were more than 10-fold lower than seen in the atomic bomb survivors, 97% of whom were exposed to doses <1 Sv.
Cell proliferation in human basal cell carcinoma. (1970)

Information about cell proliferation kinetics in human cancers has been limited by the inaccessibility of most tumors. Basal cell carcinomas are very common, slowly growing, locally invasive tumors of skin that have been studied by autoradiographic techniques using tritiated thymidine in vivo . The reproductive cycle of the germinative cell population was analyzed. The DNA synthesis period was found to be 20 hr; the G1 period, 188 hr; the G2 period, 7 hr; the mitotic period, 1.5 hr; and the total germinative cycle, approximately 217 hr. These results indicate that there is more cell proliferation activity in a basal cell carcinoma than suggested by the clinically apparent slow growth of the tumor. Therapeutic aspects of basal cell carcinoma are discussed relating to chemotherapeutic drugs.
Two-Dimensional Displacement Control of Piezoelectric Actuator Stage Driven by Series of Current Pulses (2017)

Previously, we proposed a method for driving a piezoelectric actuator using current pulses, for high-resolution and small residual vibrations. In the proposed approach, the driving pulse patterns were designed using a genetic algorithm. In this paper, positioning performance of a stage with two degrees of freedom was compared with the voltage drive by an input shaper and PI control. To enable point-to-point control, the stage was positioned at eight vertices of an octagon by input shaping, or the current pulse drive. The positioning accuracy by the current pulse drive was better than that by the voltage drive, owing to the large hysteresis of displacement with respect to the applied voltage. The current pulse drive did not excite large vibrations by integrating the current pulses. For continuous path control, the current pulse drive was also compared with the voltage drive by open-loop or proportional integral control. The current pulse drive yielded good performance for a simple open-loop control scenario, and thus can be used for device miniaturization, because in this case no displacement sensors are needed.
Development and control of a hand exoskeleton for rehabilitation of hand injuries (2005)

Hand injuries are a frequent problem. The great amount of hand injuries is not only a problem for the affected people but economic consequences follow because rehabilitation takes a long time. Physical therapy after an operation is associated with high personnel expenses. To improve therapy results and reduce cost of rehabilitation a hand exoskeleton was developed. The hand exoskeleton was specifically designed to accomplish requirements of medical applications. For research on control algorithms and rehabilitation programs a prototype supporting all four degrees of freedom of one finger was build. The device can be easily attached and also be adjusted to deformed and scarred hands. In view of the fact that a lot of hand injuries affect only one finger, this prototype could already be functional in physical therapy. This paper presents the construction and the control system of the hand exoskeleton and possible applications in therapy of hand injuries. For the position control a PID controller was implemented and evaluated. The resulting control system allows following of recorded trajectories with sufficient accuracy.