gebhart/patrepeval huggingface dataset:
Mrs. Harry [Anna] Lowenburg, Chairman State of Pennsylvania, Board of Director of Equal Franchise Lg. [League] of Pennsa [Pennsylvania] (1916)

Title and information transcribed from item.
Summary: Half-length portrait of Anna Lowenburg, facing forward, seated in chair, holding book in right hand in lap, leaning left arm to jaw, in hat.
A similar photograph of Anna Lowenburg appeared in The Suffragist, 4, no. 5 (Jan. 29, 1916), 7.
Optical nano-woodpiles: large-area metallic photonic crystals and metamaterials (2015)

Metallic woodpile photonic crystals and metamaterials operating across the visible spectrum are extremely difficult to construct over large areas, because of the intricate three-dimensional nanostructures and sub-50 nm features demanded. Previous routes use electron-beam lithography or direct laser writing but widespread application is restricted by their expense and low throughput. Scalable approaches including soft lithography, colloidal self-assembly, and interference holography, produce structures limited in feature size, material durability, or geometry. By multiply stacking gold nanowire flexible gratings, we demonstrate a scalable high-fidelity approach for fabricating flexible metallic woodpile photonic crystals, with features down to 10 nm produced in bulk and at low cost. Control of stacking sequence, asymmetry, and orientation elicits great control, with visible-wavelength band-gap reflections exceeding 60%, and with strong induced chirality. Such flexible and stretchable architectures can produce metamaterials with refractive index near zero, and are easily tuned across the IR and visible ranges.
Echocardiography of the prominent Eustachian valve—associations and complications with cyanosis and right heart obstruction (1993)

Summary We reviewed the echocardiographic features of 16 children with prominent Eustachian valves, six of whom had associated pathology of the right heart, while eight had other anomalies, primarily atrial and ventricular septal defects. The hearts of two patients were structurally normal. Prolapse of the membrane through the orifice of the tricuspid valve or through the atrial septum was present in seven patients, two of whom were symptomatic. One presented with severe cyanosis which resolved after surgical removal on the basis of the echocardiographic findings. The other presented with atrial arrhythmias which did not improve with removal. The size or behavior of the membrane, including prolapse, did not correlate with either age or presence of pathology of the right heart. The echocardiographic appearance of prominent Eustachian valves is variable. Rarely, when prominent, the valves can cause symptoms associated with obstruction to the right heart, particularly cyanosis or an arrhythmia.
2-<i>O</i>-Benzoyl-<i>myo</i>-inositol-1,3,5-orthoformate (1998)

Protected myo-inositol derivatives are important precursors in the synthesis of phosphorylated myo-inositol derivatives which play a significant role in the cellular signal transduction. The structure of the title compound, C14H14O7, which was prepared from myo-inositol, has been determined by X-ray crystallography. Several types of hydrogen-bonding interactions are involved in the packing of the molecule in the crystal.
P2392Diagnostic performance of coronary CT angiography performed by the novel whole-heart coverage high definition CT scanner in patients with very high heart rate (2017)

and cholesterol independently predicted incident CAC (n=562; Incidence rate ratio (IRR) 1.47; p=0.02 and 1.34; p=0.04, respectively), while phosphate was the only biomarker independently predicting CAC progression (n=444; IRR 3.60; p=0.007).
Recognition, Diagnosis, and Management of Wilson's Disease (2000)

Wilson's disease is a relatively rare inherited disorder of copper accumulation and toxicity, caused by a defect in an enzyme that is part of the pathway of biliary excretion of excess copper. Clinically, patients usually present as older children or young adults with hepatic, neurologic, or psychiatric manifestations, or some combination of these. Wilson's disease is unusual among genetic diseases in that it can be very effectively treated. The prevention of severe permanent damage depends upon early recognition and diagnosis by the physician, followed by appropriate anticopper treatment. Anticopper treatments have evolved considerably since the days when the only drug available was penicillamine. Zinc is now the recommended therapy for long-term management of the disease.
ChemInform Abstract: SOLID‐LIQUID PHASE‐TRANSFER CATALYSIS BY A QUATERNARY AMMONIUM SALT. A COMPARISON WITH CROWN ETHERS AND POLYALKYLAMINES (1978)

Abstract Verschiedene Substitutionsreaktionen, z.B. an (I) oder (III) zu (II) bzw. (IV),werden in Gegenwart von quaternären Ammoniumsalzen wie "Aliquat 336" als Phasen‐Transfer‐Katalysator durchgeführt, und die Wirksamkeit wird mit der von 18‐Kronen‐6‐ether oder Tetramethylethylendiamin verglichen.
In Situ Transfection by Controlled Release of Lipoplexes Using Acoustic Droplet Vaporization (2016)

Localized delivery of nucleic acids to target sites (e.g., diseased tissue) is critical for safe and efficacious gene therapy. An ultrasound-based technique termed acoustic droplet vaporization (ADV) has been used to spatiotemporally control the release of therapeutic small molecules and proteins contained within sonosensitive emulsions. Here, ADV is used to control the release of lipoplex-containing plasmid DNA encoding an enhanced green fluorescent protein reporter-from a sonosensitive emulsion. Focused ultrasound (3.5 MHz, mechanical index (MI) ≥ 1.5) generates robust release of fluorescein (i.e., surrogate payload) and lipoplex from the emulsion. In situ release of the lipoplex from the emulsion using ADV (MI = 1.5, 30 cycles) yields a 55% release efficiency, resulting in 43% transfection efficiency and 95% viability with C3H/10T1/2 cells. Without exposure to ultrasound, the release and transfection efficiencies are 5% and 7%, respectively, with 99% viability. Lipoplex released by ADV retains its bioactivity while the ADV process does not yield any measureable sonoporative enhancement of transfection. Co-encapsulation of Ficoll PM 400 within the lipoplex-loaded emulsion, and its subsequent release using ADV, yield higher transfection efficiency than the lipoplex alone. The results demonstrate that ADV can have utility in the spatiotemporal control of gene delivery.
Microarray Analyses Uncover UBE1L as a Candidate Target Gene for Lung Cancer Chemoprevention (2004)

Retinoids, natural and synthetic derivatives of vitamin A, are active in cancer therapy and chemoprevention. We reported previously that all-trans-retinoic acid (RA) treatment prevented carcinogen-induced transformation of immortalized human bronchial epithelial (HBE) cells. To identify cancer chemopreventive mechanisms, immortalized (BEAS-2B), carcinogen-transformed (BEAS-2B(NNK)), and RA-chemoprevented (BEAS-2B(NNK/RA)) HBE cells were used to conduct microarray analyses independently. Species increased in chemoprevented as compared with immortalized HBE cells (group I) and those augmented in chemoprevented as compared with transformed HBE cells (group II) included known RA-target genes as well as previously unrecognized RA-target genes in HBE cells. Unexpectedly, both groups were also enriched for interferon-stimulated genes. One interferon-stimulated gene of particular interest was UBE1L, the ubiquitin-activating enzyme E1-like protein. UBE1L expression was also induced after prolonged RA-treatment of immortalized HBE cells. UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis. Notably, UBE1L immunoblot expression was reduced in a subset of malignant as compared with adjacent normal lung tissues that were examined. Immunohistochemical analyses were performed using a new assay developed to detect this species using rabbit polyclonal anti-UBE1L antibodies independently raised against the amino- or carboxyl-termini of UBE1L. Studies done on paraffin-embedded and fixed tissues revealed abundant UBE1L, but low levels of cyclin D1 expression in the normal human bronchial epithelium, indicating an inverse relationship existed between these species. To study this further, cotransfection into HBE cells of wild-type or mutant UBE1L species was accomplished. In a dose-dependent manner, wild-type but not mutant UBE1L species repressed cyclin D1 expression. This implicated UBE1L in a retinoid chemoprevention mechanism involving cyclin D1 repression described previously. Taken together, these findings directly implicate UBE1L as a candidate-pharmacologic target for lung cancer chemoprevention. These findings also provide a mechanistic basis for the tumor suppressive effects of UBE1L through cyclin D1 repression.
A New Strategy for the Stereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes (2000)

The stereoselective synthesis of highly functionalized 1,2,3-trisubstituted cyclopropanes 1 and 2, starting from readily available furans 3 or N-protected pyrrole 4, is described. Furthermore, exceptionally high diastereocontrol in agreement with the Felkin−Anh model was observed for the addition of nucleophiles to the title compounds.
“Art, Colors, and Emotions” Treatment (ACE-t): A Pilot Study on the Efficacy of an Art-Based Intervention for People With Alzheimer’s Disease (2020)

Increasing evidence suggests that non-pharmacological therapies impact on neuropsychiatric symptoms and quality of life in people with Alzheimer's disease. Among these, art-based interventions seem particularly suitable for elders' rehabilitation as they act both on cognitive functions and quality of life. However, their benefits are not yet appropriately explored. The main aim of this quasi-experimental study was to test the feasibility and the likely efficacy of a novel multi-dimensional visual art intervention for people with Alzheimer's disease (PWAD), named Art, Colors, and Emotions treatment (ACE-t). A group of PWAD (<i>N</i> = 10) was recruited from the Memory Clinic of Don Gnocchi Foundation to take part in the ACE-t. A historical control group that followed a usual care program (<i>N</i> = 10) was used for comparison. We considered both feasibility output (adherence and acceptability) and efficacy outcome measures (neuropsychological and neurobehavioral scales). We observed a good adherence to and acceptability of the ACE-t. The following significant intervention-related changes were also observed in ACE-t with respect to usual care: improvement in general cognition, as assessed with the Alzheimer's Disease Assessment Scale-Cognitive, amelioration in language, and in executive functions, and reduction in Neuropsychiatric Inventory Scale score. In conclusion, ACE-t could be considered as a suitable intervention for the rehabilitation of PWAD, with positive effects on the cognitive and the behavioral status. ACE is a promising new art-based intervention that merits further research, including confirmatory trials of our preliminary results.
A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele (2000)

A susceptibility gene for psoriasis, a chronic skin disorder, resides in chromosome 6p near the HLA-C locus. Sequencing of the region has allowed the identification of a new gene, HCR. We found that HCR is highly polymorphic with at least 12 coding variants. An association study of the new HCR polymorphisms and the previously suggested susceptibility alleles HLA-Cw*0602 and corneodesmosin allele 5 (CD*5) with psoriasis revealed a specific HCR variant associated with psoriasis susceptibility. However, the HLA-Cw*0602 allele was rarer in controls and associated with a stronger relative risk. Association analysis did not support CD*5 as a psoriasis susceptibility allele in our sample of patients (n = 100) and population-matched controls (n = 93) from an isolated population. We found HCR to be overexpressed in keratinocytes of psoriatic lesions compared with paired samples of healthy skin. Our results suggest a potential role for HCR in the pathogenesis of psoriasis.
Reductive Dimerization of Allyl and Benzyl Halides in Pb/<i>n</i>-Bu4NBr–DMF and PbBr2/Al–DMF Systems (1987)

Abstract Reductive dimerization of allyl and benzyl halides has been performed by treatment with Pb/n-Bu4NBr and catalytic PbBr2/Al in N,N-dimethylformamide.
Research on the McCarthy Scales and Its Implications for Assessment (1977)

This paper reviews the research on the McCarthy Scales of Children's Abilities, which are designed to assess several areas of a child's cognitive and motor development from the age of 21/2 to 81/2 years. Pertinent research findings are considered in terms of their implications for assessment; the real possibility that McCarthy's General Cognitive Index GCI is different from the IQ is explored. Other types of investigations needed to help validate the instrument and better define its clinical usefulness also are mentioned. Finally, the roles of the McCarthy in different aspects of psychoeducational diagnosis are discussed in view of present knowledge about the instrument.
Antibodies to <i>Chlamydia trachomatis</i> heat shock proteins Hsp60 and Hsp10 and subfertility in general population at age 31 (2004)

The results indicate a serological association of antibodies to chlamydial Hsp antigens with female subfertility in a population-based sample.
Novel Anode Material for Lithium-ion Batteries: Carbon-Coated Silicon Prepared by Thermal Vapor Decomposition (2001)

Abstract Carbon-coated Si has been prepared by thermal vapor decomposition technique. The electrochemical behaviors of carbon-coated Si together with Si have been investigated as anode materials for lithium-ion batteries. The good cycleability of carbon-coated Si under lithiation capacity of 1200 mA h/g has been correlated with ex situ XRD patterns as well as SEM graphs.
The change in dietary inflammatory index score is associated with control of long-term rheumatoid arthritis disease activity in a Japanese cohort: the TOMORROW study (2020)

Abstract Background The dietary inflammatory index (DII ® ), a quantitative measure of the inflammatory potential of daily food and nutrient intake, and associations between a variety of health outcomes have been reported. However, to the best of our knowledge, there is no report which investigated the association between rheumatoid arthritis (RA) and DII. Therefore, we investigate the association between the DII and disease activity in patients with RA. Methods We performed a cross-sectional and longitudinal analysis using 6 years of data (from 2011 to 2017) in TOMORROW, a 10-year prospective cohort study consisting of 208 RA patients and 205 gender- and age-matched non-RA controls recruited in 2010. Disease activity of RA patients was assessed annually using DAS28-ESR (disease activity score 28 joints and the erythrocyte sedimentation rate) as a composite measure based on arthritic symptoms in 28 joints plus global health assessment and ESR. Dietary data were collected in 2011 and 2017 using the brief-type self-administered diet history questionnaire (BDHQ). Energy-adjusted DII (E-DII TM ) score was calculated using 26 nutrients derived from the BDHQ. Data were analyzed with two-group comparisons, correlation analysis, and multivariable logistic regression analysis. Results RA patients had significantly higher E-DII (pro-inflammatory) score compared to controls both in 2011 and 2017 ( p < 0.05). E-DII score showed statistically significant negative correlation with age in RA patients, both in 2011 ( r = -0.20) and 2017 ( r = -0.23). Controls also showed a similar trend. In RA patients, E-DII score was not a factor associated with disease activity in a cross-sectional analysis. However, decline in E-DII (anti-inflammatory change) score was a factor that increased the odds of maintaining low disease activity (DAS28-ESR ≤ 3.2) or less for 6 years (OR: 4.33, 95%CI: 1.66-11.29, p = 0.003). Conclusions E-DII score was high in RA patients and lowering E-DII score over time may be beneficial in controlling disease activity in patients with RA. Trial registration UMIN Clinical Trials Registry, http://www.umin.ac.jp/ctr/, UMIN000003876. Registered 7 Aug 2010 - Retrospectively registered.
Evidence That the wzxE Gene of Escherichia coli K-12 Encodes a Protein Involved in the Transbilayer Movement of a Trisaccharide-Lipid Intermediate in the Assembly of Enterobacterial Common Antigen (2003)

The assembly of many bacterial cell surface polysaccharides requires the transbilayer movement of polyisoprenoid-linked saccharide intermediates across the cytoplasmic membrane. It is generally believed that transverse diffusion of glycolipid intermediates is mediated by integral membrane proteins called translocases or "flippases." The bacterial genes proposed to encode these translocases have been collectively designated wzx genes. The wzxE gene of Escherichia coli K-12 has been implicated in the transbilayer movement of Fuc4NAc-ManNAcA-GlcNAc-P-P-undecaprenol (lipid III), the donor of the trisaccharide repeat unit in the biosynthesis of enterobacterial common antigen (ECA). Previous studies (Feldman, M. F., Marolda, C. L., Monteiro, M. A., Perry, M. B., Parodi, A. J., and Valvano, M. (1999) J. Biol. Chem. 274, 35129-35138) provided indirect evidence that the wzx(016) gene product of E. coli K-12 encoded a translocase capable of mediating the transbilayer movement of N-acetylglucosaminylpyrophosphorylundecaprenol (GlcNAc-P-P-Und), an early intermediate in the synthesis of ECA and many lipopolysaccharide O antigens. Therefore, genetic and biochemical studies were conducted to determine if the putative Wzx(O16) translocase was capable of mediating the transport of N-acetylglucosaminylpyrophosphorylnerol (GlcNAc-P-P-Ner), a water-soluble analogue of GlcNAc-P-P-Und. [(3)H]GlcNAc-P-P-Ner was transported into sealed, everted cytoplasmic membrane vesicles of E. coli K-12 as well as a deletion mutant lacking both the wzx(016) and wzxC genes. In contrast, [(3)H]GlcNAc-P-P-Ner was not transported into membrane vesicles prepared from a wzxE-null mutant, and metabolic radiolabeling experiments revealed the accumulation of lipid III in this mutant. The WzxE transport system exhibited substrate specificity by recognizing both a pyrophosphoryl-linked saccharide and an unsaturated alpha-isoprene unit in the carrier lipid. These results support the conclusion that the wzxE gene encodes a membrane protein involved in the transbilayer movement of lipid III in E. coli.
F-18 FDG PET/CT in Acute Respiratory Distress Syndrome: A Case Report (2004)

F-18 FDG PET/CT has become a useful technique in the evaluation of pulmonary lesions. We present a case of markedly increased and diffuse pulmonary F-18 FDG activity in a patient with acute respiratory distress syndrome (ARDS). High rates of glucose utilization by the inflammatory cells involved in the pathogenesis of ARDS might explain the increased pulmonary F-18 FDG uptake we observed. In the proper clinical setting, ARDS should be considered in the differential diagnosis of patients with diffusely increased F-18 FDG activity in the lungs.
Chitin pleomorphism in the cellulosic cell wall fungus<i>Saprolegnia</i> (1992)

The presence of α chitin in hyphal walls and regenerating protoplast walls of the cellulosic fungus Saprolegnia monoica has been demonstrated by biophysical analyses. In hyphal walls, chitin appeared as globular particles while in protoplast walls chitin had a microfibrillar structure. Chitin synthesized in vitro by partially purified soluble chitin synthase appeared as spindle-like particles. This variation of morphology may reflect the structural role played by crystalline chitin during morphogenesis.
Thermal effects in a coplanar-pumped folded-zigzag slab laser (1996)

The properties of a coplanar-pumped folded-slab laser under the influence of thermal lensing have been modeled and measured. It is shown that despite the formation of a strong astigmatic lens within the slab, the results can be used to design resonators capable of good TEM/sub 00/ performance, suitable for a wide variety of applications. Good agreement is found between modeling and measurement of slab and laser parameters. Using a novel technique, the fraction of absorbed pump power converted to heat has been measured under diode-laser pumping.
Suppression of Human Prostate Cancer Cell Growth by β-Lapachone via Down-regulation of pRB Phosphorylation and Induction of Cdk Inhibitor p21<sup>WAF1/CIP1</sup> (2003)

The product of a tree (Tabebuia avellanedae) from South America, beta-lapachone, is known to exhibit various pharmacological properties, the mechanisms of which are poorly understood. The aim of the present study was to further elucidate the possible mechanisms by which beta-lapachone exerts its anti-proliferative action in cultured human prostate cancer cells. We observed that the proliferation-inhibitory effect of beta-lapachone was due to the induction of apoptosis, which was confirmed by observing the morphological changes and cleavage of the poly(ADP-ribose) polymerase protein. A DNA flow cytometric analysis also revealed that beta-lapachone arrested the cell cycle progression at the G1 phase. The effects were associated with the down-regulation of the phosphorylation of the retinoblastoma protein (pRB) as well as the enhanced binding of pRB and the transcription factor E2F-1. Also, beta-lapachone suppressed the cyclin-dependent kinases (Cdks) and cyclin E-associated kinase activity without changing their expressions. Furthermore, this compound induced the levels of the Cdk inhibitor p21(WAF1/CIP1) expression in a p53-independent manner, and the p21 proteins that were induced by beta-lapachone were associated with Cdk2. beta-lapachone also activated the reporter construct of a p21 promoter. Overall, our results demonstrate a combined mechanism that involves the inhibition of pRB phosphorylation and induction of p21 as targets for beta-lapachone. This may explain some of its anticancer effects.
Tanshinone IIA increases levels of NeuN, protein disulfide isomerase, and Na+/K+-ATPase and decreases evidence of microglial activation after cerebral ischemic injury (2016)

This study was designed to clarify the neuroprotective effects of tanshinone IIA (TSA) following cerebral ischemic insult. Adult Sprague-Dawley rats were operated upon to achieve a middle cerebral artery occlusion to cause transient focal cerebral ischemia, which were then randomly divided into the sham-operated control group and cerebral ischemia/reperfusion (I/R) groups receiving a 2 h occlusion. The treatment groups received daily intraperitoneal injections of high or low doses of TSA, for 7 or 15 days. NeuN immunostaining revealed neuronal loss following I/R, which was partially prevented with subsequent TSA dosing. Protein disulfide isomerase and adenosine triphosphatase (Na(+)/K(+)-ATPase) levels were all depressed by means of I/R. TSA treatment markedly reversed the depression of all indices examined. The intensity of microglial activation, as evidenced with CD11b staining, was increased by means of cerebral artery occlusion, but this was partially reversed with subsequent TSA treatment. TSA may affect neuroprotection by way of minimizing deficits in energy metabolism and reduction of the extent of cell death within affected regions.