gebhart/patrepeval huggingface dataset:
Mouse lines with photo‐activatable mitochondria to study mitochondrial dynamics (2012)

Many pathological states involve dysregulation of mitochondrial fusion, fission, or transport. These dynamic events are usually studied in cells lines because of the challenges in tracking mitochondria in tissues. To investigate mitochondrial dynamics in tissues and disease models, we generated two mouse lines with photo-activatable mitochondria (PhAM). In the PhAM(floxed) line, a mitochondrially localized version of the photo-convertible fluorescent protein Dendra2 (mito-Dendra2) is targeted to the ubiquitously expressed Rosa26 locus, along with an upstream loxP-flanked termination signal. Expression of Cre in PhAM( floxed) cells results in bright mito-Dendra2 fluorescence without adverse effects on mitochondrial morphology. When crossed with Cre drivers, the PhAM(floxed) line expresses mito-Dendra2 in specific cell types, allowing mitochondria to be tracked even in tissues that have high cell density. In a second line (PhAM(excised) ), the expression of mito-Dendra2 is ubiquitous, allowing mitochondria to be analyzed in a wide range of live and fixed tissues. By using photo-conversion techniques, we directly measured mitochondrial fusion events in cultured cells as well as tissues such as skeletal muscle. These mouse lines facilitate analysis of mitochondrial dynamics in a wide spectrum of primary cells and tissues, and can be used to examine mitochondria in developmental transitions and disease states.
Responses to cholecystokinin octapeptide in patients with functional abdominal pain syndromes (1992)

Clues to the pathogenesis of functional pain syndromes may be derived from the study of stimuli that precipitate or aggravate symptoms. In this study, cholecystokinin octapeptide (CCK-8, 0.06 microgram/kg) and placebo were given by intravenous infusion (5 min) in random order to control subjects and four groups of patients with unexplained abdominal pain. Induction of pain and nausea were assessed by linear analogue scales while sympathoadrenomedullary responses were assessed by serial changes in plasma concentrations of noradrenaline, adrenaline and dopamine. Scores for pain and nausea were low after infusion of placebo. After infusion of CCK-8, pain scores were significantly higher in patients with spontaneous pain than in control subjects, but significant increases in nausea were restricted to patients with irritable bowel syndrome and a subgroup of patients with pain after cholecystectomy. Although some groups showed increases in plasma concentrations of catecholamines after the infusion of CCK-8, the size of these increases was neither consistent among patients within each group nor predictive of scores of pain and nausea in individual subjects. Pain during the infusion of CCK-8 was a feature common to patients with diverse functional pain syndromes, and did not appear to be attributable to activation of the sympathetic nervous system.
Le CRPP et la recherche en fusion (1993)

Note: Proc. Journee d'Information de l'ETG, EPF-Lausanne, Mars 1993, 5 - 21 (1993) Reference CRPP-CONF-1993-014 Record created on 2008-05-13, modified on 2017-05-12
Fast Video Deduplication via Locality Sensitive Hashing with Similarity Ranking (2016)

The explosive growth of the massive video data brings great challenges to the fast video deduplication. There is encouraging progress of the deduplication techniques in the past few years, especially with the help of the binary hashing methods. However, till now there is rare work that studies the generic hash based framework and the efficient similarity ranking strategy for video deduplication. This paper proposes a flexible and fast video deduplication framework based on hash codes, which supports the hash table indexing using any existing hashing algorithm, and ranks the candidate videos by exploring the similarities among the key frames over multiple tables. Our experiments on the popular large-scale dataset demonstrate that the proposed framework can achieve satisfying performance in the task of video deduplication.
Rescue ICSI of oocytes that failed to extrude the second polar body 6 h post-insemination in conventional IVF (2003)

Rescue ICSI after 6 h post-insemination (46 h post-HCG) gave better fertilization, pregnancy and implantation rates compared with rescue ICSI after 22 h when oocytes have become aged.
Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network (2009)

The ability to rise above the present environment and reflect upon the past, the future, and the minds of others is a fundamentally defining human feature. It has been proposed that these three self-referential processes involve a highly interconnected core set of brain structures known as the default mode network (DMN). The DMN appears to be active when individuals are engaged in stimulus-independent thought. This network is a likely candidate for supporting multiple processes, but this idea has not been tested directly. We used fMRI to examine brain activity during autobiographical remembering, prospection, and theory-of-mind reasoning. Using multivariate analyses, we found a common pattern of neural activation underlying all three processes in the DMN. In addition, autobiographical remembering and prospection engaged midline DMN structures to a greater degree and theory-of-mind reasoning engaged lateral DMN areas. A functional connectivity analysis revealed that activity of a critical node in the DMN, medial prefrontal cortex, was correlated with activity in other regions in the DMN during all three tasks. We conclude that the DMN supports common aspects of these cognitive behaviors involved in simulating an internalized experience.
Where Did You Sleep Last Night?: Measuring Homelessness in Brisbane's Inner City (2007)

Advocating and securing services for people sleeping out and/or living in public spaces has always presented a number of challenges. The challenges have been exacerbated because, in many cases, the number of people experiencing primary homelessness is unknown, contested or both.
Optical Satellite Links For ESA's Space Missions (1987)

Optical inter-satellite links are foreseen in ESA's satellite communication projects for the linking of two geostationary telecommunication satellites and in the context of the European Data Relay Satellite project (DRS). In preparation of these missions, a Payload and Spacecraft Demonstration and Experimentation (PSDE) programme has been set up for the in-flight demonstration of optical space links in the early 1990s. This paper reports on the progress of system studies and related technology developments.
Robust baud rate blind equalization for ATSC DTV receivers (2007)

A robust adaptive decision feedback equalizer (DFE) for ATSC standard terrestrial digital television (DTV) receivers is presented. Favorable transient and steady-state performance in representative channel conditions is achieved by adapting filter coefficients using a modified constant modulus algorithm. Computer simulations verify stable convergence of a DFE with an extended feedforward filter, which attenuates pre- echo aliases and thus reduces the steady-state mean-square error. Another contribution of the paper is to demonstrate sufficient resilience of a symbol-spaced feedforward filter to timing phase offsets, obviating the need for a fractionally-spaced feedforward section and consequently reducing the hardware requirements.
Novel antioestrogens (1989)

Synopsis Recently described 7α-alkylamide analogues of oestradiol, exemplified by ICI 164,384, have the pharmacological characteristics of pure antioestrogens. ICI 164,384 is completely free of oestrogenic activity in rodents and blocks the trophic actions of exogenous and endogenous oestradiol and of partial agonist antiooestrogens like tamoxifen. In addition, ICI 164,384 is peripherally selective, producing complete involution of the uterus without affecting LH secretion in intact female rats. In MCF-7 oestrogen-responsive, human breast cancer cells ICI 164,384 is a more potent and effective inhibitor of cell growth than tamoxifen. This difference in efficacy is reflected by a greater reduction in the proportion of cells continuing DNA synthesis in ICI 164,384-treated cultures than in tamoxifen-treated cells. This observation implies that a pure antioestrogen may provide more effective therapy of breast cancer but this will have to be demonstrated in clinical studies.
ChemInform Abstract: Ethyl Chloroformate/DMF in Organic Synthesis. Part 1. A Novel Reagent for Ring Closure of 5‐Amino‐1‐aryl‐4‐imidazolecarboxamides to Their Hypoxanthine Derivatives. (1989)

Abstract The reaction between the 5‐amino‐4‐imidazolecarboxamides (I) and a mixture of DMF (II) and ethyl chloroformate proceeds under comparatively mild conditions to afford the hypoxanthine derivatives (III) instead of the expected xanthines.
A high-frequency reciprocating drill (1953)

An instrument is described which uses intense mechanical vibrations at ultrasonic frequency for drilling and cutting brittle materials. To generate the vibrations, a high Q magnetostriction transducer is used in conjunction with a suitable step-up velocity transformer. The instrument is essentially a high-speed reciprocating drill which enables complicated machining operations to be performed rapidly and easily in most brittle materials.
An Examination of the Relationship Between Five Oriental Musical Tones and Corresponding Internal Organs and Meridians (2004)

The Yellow Emperor's Internal Medicine (Nei-Jing) describes the relationship between five internal organs corresponding to five different meridians and five oriental musical tones such as Gung (spleen), Sang (liver), Gak (liver), Chi (heart), Wu (kidney). However, there has been little research to test this relationship. The purpose of this study was to determine this relationship through applying sound stimulation for 60 seconds, comprising various frequencies produced on an electric organ(Gung: 261.6 Hz; Sang: 293.7 Hz; Gak: 329.6 Hz Chi: 392.0 Hz and Wu: 440.0 Hz), to 20 healthy adults by stimulating their ears (via headphones), skin (via speakers) and both. A significant relationship was found between the tones and the meridians as they are described in Nei-Jing. The greatest response rates were found in the following corresponding organic and musical tones: spleen/Gung, lung/Sang, liver/Gak, heart/Chi, and kidney/Wu. The traditional descriptions of Yellow Emperor's Nei-Jing are therefore consistent with the findings of this study. Further basic research may lead to the application of clinically appropriate tones in an acoustically suitable room following oriental medical diagnosis.
Broca's Localization Theory Reconsidered (1980)

The paper gives an account of Broca's historical article “Remarques sur le siège de la faculté du langage articulé” (1861). It focuses on Broca's reflections regarding the general faculty of language. By virtue of a critical analysis of Broca's arguments it is demonstrated that Broca did not advocate the theories of his forerunners, but that he attempted to modify strict localization by proposing localization according to convolutions.
Microstructure and magnetic properties of Fe100−xPtx alloy films (1999)

Polycrystalline Fe100−xPtx alloy thin films with Pt composition x=25–67 at. % were prepared by dc magnetron sputtering on natural-oxidized silicon wafer substrates, then postannealed in vacuum at various temperatures and over different periods. The effects of film composition, magnetic layer thickness, annealing temperature, and annealing time on the magnetic properties parallel and normal to the film plane were investigated. Films with high in-plane coercivity could be obtained by annealing the films in the temperature range between 400 and 650 °C. Optimum in-plane squareness and coercivity of the film occurred at a film composition of Fe50Pt50 with thickness of about 200 nm after annealing at 600 °C for 30 min. The analyses of transmission electron microscopy diffraction patterns indicated that this annealed Fe50Pt50 film was nearly entirely in the fct γ1-FePt phase. The average grain size of this Fe50Pt50 film was about 85 nm. The grain size was almost independent of the cooling rate after annealing, but the magnetic hardening mechanism and coercivity of the annealed film was largely dependent on the cooling rate.
Prediction of neutral salt elution profiles for affinity chromatography. (1981)

Neutral salts exhibit very marked differences as eluants of proteins from affinity columns. We observe: (i) that the relative potencies of neutral salts as eluants are independent of the protein or the affinity ligand in the systems studied, (ii) that the absolute salt concentration necessary to elute any given protein bound to the affinity matrix is proportional to the algebraic sum of a set of elution coefficients defined herein for the separate ions present in the solution, and (iii) that the proportionality between elution potency and elution coefficient is a function of the affinity of the protein for the immobilized ligand. Given the concentration of one neutral salt required for elution of a protein of interest from an affinity column, the elution capability of any neutral salt at any temperature can be quantitatively predicted for that protein. Accordingly, application and elution protocols for affinity chromatography can be designed to optimize the yield and fold purification of proteins.
Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures (2017)

Chinese hamster ovary (CHO) cells have been widely used for producing many recombinant therapeutic proteins. Constraint-based modeling, such as flux balance analysis (FBA) and metabolic flux analysis (MFA), has been developing rapidly for the quantification of intracellular metabolic flux distribution at a systematic level. Such methods would produce detailed maps of flows through metabolic networks, which contribute significantly to better understanding of metabolism in cells. Although these approaches have been extensively established in microbial systems, their application to mammalian cells is sparse. This review brings together the recent development of constraint-based models and their applications in CHO cells. The further development of constraint-based modeling approaches driven by multi-omics datasets is discussed, and a framework of potential modeling application in cell culture engineering is proposed. Improved cell culture system understanding will enable robust developments in cell line and bioprocess engineering thus accelerating consistent process quality control in biopharmaceutical manufacturing.
The immunological classification of acute lymphoblastic leukemias (1978)

The main methods used in order to assess the immunological markers on the blast cells from patients with acute lymphoblastic leukemia (ALL) are critically evaluated. The classification of ALL according to the phenotype of the leukemic cells and their presumed origin is reviewed. The correlations with clinical features and prognosis, as well as their possible therapeutic implications, are discussed.
Adaptive control of nonlinear multivariable systems using neural networks (2002)

In this paper we examine the problem of control of multivariable systems using neural networks. The problem is discussed assuming different amounts of prior information concerning the plant and hence different levels of complexity. In the first stage it is assumed that the state equations describing the plant are known and that the state of the system is accessible. Following this the same problem is considered when the state equations are unknown. In the last stage the adaptive control of the multivariable system using only input-output data is discussed in detail. The objective of the paper is to demonstrate that results from nonlinear control theory and linear adaptive control theory can be used to design practically viable controllers for unknown nonlinear multivariable systems using neural networks. The different assumptions that have to be made, the choice of identifier and controller architectures and the generation of adaptive laws for the adjustment of the parameters of the neural networks form the core of the paper. >
Successful Treatment of Subacute Lupus Erythematosus With Ustekinumab (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Optical system requirements for laser scanning systems (1987)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Robert E. Hopkins, "Optical system requirements for laser scanning systems," Optics News 13(11), 11-16 (1987) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
<title>Transaction recording in medical image processing</title> (1999)

In medical image processing original image data on archive servers may absolutely not be modified directly. On the other hand, images from read-only devices like CD-ROM cannot be changed and saved on the same storage medium. In both cases the modified data have to be stored as a second version and large amounts of storage volume are needed. We avoid these problems by using a program which records only each transaction prescribed to images. Each transaction is stored and used for further utilization and for renewed submission of the modified data. Conventionally, every time an image is viewed or printed, the modified version has to be saved in addition to the recorded data, either automatically or by the user. Compared to these approaches which not only squander storage space but area also time consuming our program has the following and advantages: First, the original image data which may not be modified are protected against manipulation. Second, small amounts of storage volume and network range are needed. Third, approved image operations can be automated by macros derived from transaction recordings. Finally, operations on the original data can always be controlled and traced back. As the handling of images gets easier with this concept, security for original image data is granted.
Inhibiting angiotensin type 1 receptors as a target for diabetes (2008)

The Ongoing Telmisartan Alone and in Combination with Ramipril Global End point Trial (ONTARGET) has provided information to answer these questions, and is discussed.
Autonomous Unmanned Aerial Vehicle Rendezvous for Automated Aerial Refueling (2012)

As unmanned aerial vehicles (UAVs) increase in capability, the ability to refuel them in the air is becoming more critical. Aerial refueling will extend the range, shorten the response times, and extend loiter time of UAVs. Executing aerial refueling autonomously will reduce the command and control, logistics, and training efforts associated with fielding UAV systems. Currently, the Air Force Research Lab is researching the various technologies required to conduct automated aerial refueling (AAR). One of the required technologies is the ability to autonomously rendezvous with the tanker. The goal of this research is to determine the control required to fly an optimum rendezvous using numerical optimization and to design a controller that will approximate that control. Two problems were examined. The first problem is for the receiver to rendezvous in minimum time, with a known tanker path. The second problem is for the receiver to rendezvous at a specified time with a known tanker path. For the first problem, the simulated controller results will be compared to the calculated optimal control.
Complex Explanation (2002)

Every so often vaccines don't quite work as planned, as occurred in the 1960s when a vaccination program against respiratory syncytial virus (RSV) led to worse, rather than better, responses in children who subsequently were exposed to the virus. The primary cause of enhanced RSV disease was traced to the use of formalin as a means of inactivating the virus in vaccine preparations, although why this should adversely affect immunity to RSV remained unclear.
Laser Soldering and Laser Droplet Joining for Mechanical and Electrical Contacting of LTCC/PZT Laminates (2011)

Present research in the field of active noise reduction for automotive components deals with piezoelectric laminates embedded into parts like aluminium gear boxes, car bodies or clutch housings fabricated by die casting or forced-locked insertion. Under closed loop operation, these parts are able to modify the oscillation behaviour and noise of the whole construction. Precondition for such solutions are specially designed laminates which guarantee power transmission into the parts as well as reproducible electrical and mechanical connections between the laminates and the electrical contacts. PZT actuators which are embedded in Low Temperature Cofired Ceramic (LTCC) laminates are promising for this application. This paper discusses current results of laser soldering and laser droplet joining on LTCC/PZT samples with screen printed silver pads. Laser soldered contacts allow the application of the laminates in automotive parts subjected to low thermal loads. The experimental setup for the realisation of laser solder joints on the laminates is described and the results of micrograph analysis and shear force measurements are discussed. For high temperature stable connections laser droplet joining with brazing material is used. The thermal energy of the applied molten droplets needs to be adjusted in order to prevent the laminates and their pads from being damaged. The process technology and results for the creation of crack-free connections are described.
Report on New Methods for Representing and Interacting with Qualitative Geographic Information, Stage 2: Task Group 1 Core Re-engineering and Place-based Use Case (2013)

Abstract : This report documents Pennsylvania State University's (PSU) research on place-focused analysis of microblogs, specifically Twitter. The first section of the report identifies three categories of location information related to tweets: the location where a tweet originates, places mentioned in tweets, and the profile location of the tweeter. The report summarizes previous research on location information and contributes new insights resulting from additional PSU analysis. The second section of the report focuses on the visualization of place information. Place trees, place clouds, and place-coreferencing are introduced in the context of the SensePlace2 system. The third section of the report summarizes the SensePlace2 system architecture enhancements required to support the dynamic visualization of Twitter location information, including the development of an innovative user interface coordination mechanism and implementation of faceted search using Apache Solr.