gebhart/patrepeval huggingface dataset:
Faculty Opinions recommendation of A seven-transmembrane RGS protein that modulates plant cell proliferation. (2003)

G protein-coupled receptors (GPCRs) at the cell surface activate heterotrimeric G proteins by inducing the G protein alpha (Galpha) subunit to exchange guanosine diphosphate for guanosine triphosphate. Regulators of G protein signaling (RGS) proteins accelerate the deactivation of Galpha subunits to reduce GPCR signaling. Here we identified an RGS protein (AtRGS1) in Arabidopsis that has a predicted structure similar to a GPCR as well as an RGS box with GTPase accelerating activity. Expression of AtRGS1 complemented the pheromone supersensitivity phenotype of a yeast RGS mutant, sst2Delta. Loss of AtRGS1 increased the activity of the Arabidopsis Galpha subunit, resulting in increased cell elongation in hypocotyls in darkness and increased cell production in roots grown in light. These findings suggest that AtRGS1 is a critical modulator of plant cell proliferation. PMID: 14500984 Funding information This work was supported by: NIGMS NIH HHS, United States Grant ID: R01 GM065989-03 NIGMS NIH HHS, United States Grant ID: R01 GM065989-04 NIGMS NIH HHS, United States Grant ID: R01 GM065989 NIGMS NIH HHS, United States Grant ID: GM62338 NIGMS NIH HHS, United States Grant ID: R01 GM065989-01 NIGMS NIH HHS, United States Grant ID: GM65989 NIGMS NIH HHS, United States Grant ID: GM055316 NIGMS NIH HHS, United States Grant ID: R01 GM065989-02 NIGMS NIH HHS, United States Grant ID: GM65533 More Less keyboard_arrow_down
On the scalability of cooperative time synchronization in pulse-connected networks (2006)

The problem of time synchronization in dense wireless networks is considered. Well-established synchronization techniques suffer from an inherent scalability problem in that synchronization errors grow with an increasing number of hops across the network. In this work, a model for communication in wireless networks is first developed, and then the model is used to define a new time synchronization mechanism. A salient feature of the proposed method is that, in the regime of asymptotically dense networks, it can average out all random errors and maintain global synchronization in the sense that all nodes in the multihop network can see identical timing signals. This is irrespective of the distance separating any two nodes.
Development of an Electron-Positron Source for Positron Annihilation Lifetime Spectroscopy (2007)

Abstract : The extremely strong fields produced by focusing powerful laser pulses into minute volumes of material enable relativistic effects to be used to generate radiation, to accelerate particles, and to produce electrons and positrons from vacuum. From applications using existing high-repetition-rate lasers to those projected for super intense systems, the individual and collective behavior of electrons is the hub of both practical and theoretical directions. This report reviews work directed toward the application of positron generation from laser interaction with matter and vacuum. It spans funded original experimental research in laser-plasma interaction, where electrons dominate energy transport and MeV/micrometer fields are revealed, to theoretical collaborations exploring the connection between present and foreseeable lasers to the quantum electrodynamics of radiating electrons and electron-positron pair production from vacuum.
Aircraft-sized anechoic chambers for electronic warfare, radar and other electromagnetic engineering evaluation (2017)

ABSTRACT This paper considers capabilities and benefits of aircraft-sized radio/radar frequency anechoic chambers for Test and Evaluation (T&E) of Electronic Warfare (EW), radar and other electromagnetics aspects of air and ground platforms. There are few such chambers worldwide. Initially developed to reduce costs, timescales and risks associated with open-air range flight testing of EW systems, their utility has expanded to most areas of platforms’ electromagnetics’ T&E. A key feature is the ability to conduct T&E of nationally sensitive equipment and systems, fully installed on platforms, in absolute privacy. Chambers’ capabilities and uses are described, with emphasis on key infrastructure and instrumentation. Non-EW uses are identified and selected topics elaborated. Operation and maintenance are discussed, based on experiential knowledge from international use and the authors’ 30 years’ involvement with BAE Systems’ EW Test Facility. A view is provided of trends and challenges whose resolution could further increase chamber utility. National affordability challenges also suggest utility expansion to support continuing moves, from expensive and difficult to repeat flight test and operational evaluation trials, towards an affordability-driven optimal balance between modelling and simulation, and real-world testing of platforms.
CEREBRAL HEMODYNAMIC RESPONSE TO MIVACURIUM CHLORIDE (1994)

Mallikarjuna, M. MD; Lu, G. P. MD; Gibson, J. Jr., BS; Monell, C.; Osborn, I. MD Author Information
Initial calibration of the Ford Nuclear Reactor (1958)

A case is described in which a middle-aged male presented with a large tracheocele in the neck arising from the right postero-lateral aspect of trachea at the level of T2 vertebra. It was not associated with any predisposing factors and except for the swelling in the neck the patient was asymptomatic. It was excised completely through the cervical approach and there has been no recurrence in two years follow-up.
Chirped multilayer mirrors for dispersion control of femtosecond pulses (1994)

Standard femtosecond self-mode-locked oscillators contain a pair of Brewster-angled prisms for producing a net negative group-delay dispersion (GDD) in the resonator. Prism pairs have been widely used for intracavity dispersion control in dye systems and adopted for the new generation of solid-state short-pulse lasers. Extensive theoretical and experimental research revealed that cubic phase dispersion introduced by the intracavity prism pair is the dominant factor limiting the minimum achievable pulse width in ultrafast solid state lasers. This finding prompted search for prism materials exhibiting low cubic phase error and led to the construction of fused-silica-prism-controlled Ti:sapphire lasers, 1 which are capable of generating pulses down to 11/s in duration. 2
Effects of intracellular trehalose content on Streptomyces griseus spores (1987)

The disaccharide trehalose is accumulated as a storage product by spores of Streptomyces griseus. Growth on media containing excess glucose yielded spores containing up to 25% of their dry weight as trehalose. Spores containing as little as 1% of their dry weight as trehalose were obtained during growth on media containing a limiting amount of glucose. Spores containing low levels of trehalose accumulated this sugar when incubated with glucose. The increase in trehalose content coincided with increases in spore refractility, heat resistance, desiccation resistance, and the time required for spore germination in complex media. Trehalose is accumulated by a wide variety of actinomycetes and related bacteria and may be partially responsible for their resistance properties.
Kinetics of the UV‐induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication (2009)

It has been reported that exposure to UV light triggers DNA damage response (DDR) seen as induction of gammaH2AX not only in S- but also in G(1)-phase cells. In the present study, in addition to gammaH2AX, we assessed other markers of DDR, namely phosphorylation of ATM on Ser1981, of ATM/ATR substrate on Ser/Thr at SQ/TQ cluster domains and of the tumor suppressor p53 on Ser15, in human pulmonary carcinoma A549 cells irradiated with 50 J/m(2) of UV-B. Phosphorylation of these proteins detected with phospho-specific Abs and measured by laser scanning cytometry in relation the cell cycle phase was found to be selective to S-phase cells. The kinetics of phosphorylation of ATM was strikingly similar to that of ATM/ATR substrate, peaking at 30 min after UV irradiation and followed by rapid dephosphorylation. The peak of H2AX phosphorylation was seen at 2 h and the peak of p53 phosphorylation at 4 h after exposure to UV light. Local high spatial density of these phospho-proteins reported by intensity of maximal pixel of immunofluorescence in the DDR nuclear foci was distinctly more pronounced in the early compared to late portion of S-phase. Exposure of cells to UV following 1 h pulse-labeling of their DNA with 5-ethynyl-2'deoxyuridine (EdU) made it possible to correlate the extent of DNA replication during the pulse with the extent of the UV-induced H2AX phosphorylation within the same cells. This correlation was very strong (R(2) = 0.98) and the cells that did not incorporate EdU showed no evidence of H2AX phosphorylation. The data are consistent with the mechanism in which stalling of DNA replication forks upon collision with the primary UV-induced DNA lesions and likely formation of double-strand DNA breaks triggers DDR. The prior reports (including our own) on induction of gammaH2AX in G(1) cells by UV may have erroneously identified cells initiating DNA replication following UV exposure as G(1) cells due to the fact that their DNA content did not significantly differ from that of G(1) cells that had not initiated DNA replication.
Biaxial elastic properties of rat arteries in vivo: influence of vascular wall cells on anisotropy (1994)

There is no consensus as to the degree of arterial anisotropy or to its relationship to vascular cell function. Given the relevance of the isotropic assumption in formulating elasticity models, reliable measures of biaxial displacements are needed. In this study, a video motion analyzer (VMA) was used to describe the biaxial in vivo dynamic elasticity of 22 carotid arteries and 5 abdominal aortas in 27 rats. The influence of vascular cell function was also examined by subjecting six rats to a photosensitive drug, chloroaluminum sulfonated phthalocyanine (CASPc), which is focally cytotoxic on activation by laser. Circumferential compliance (Ccirc) was greater than longitudinal compliance (Clong) for all vessels. Compliance pressure curves were nonlinear, and biaxial displacements were in phase. The circumferential elastic modulus was less than the longitudinal modulus at common stresses. CASPc + laser reduced Ccirc but not Clong, thus altering Poisson's ratio. In conclusion, rat arteries are biaxially, nonlinearly elastic and anisotropic in vivo. Vascular cells modulate Poisson's ratio by influencing Ccirc.
A Patterned TiO2(Anatase)/TiO2(Rutile) Bilayer-Type Photocatalyst: Effect of the Anatase/Rutile Junction on the Photocatalytic Activity (2002)

Die Kombination zweier Kristallformen von TiO2, Anatas und Rutil, in einer Doppelschichtanordnung erhöht die photokatalytische Aktivität relativ zu der von Anatas oder Rutil allein. Eine Verringerung der Dimensionen der Phasengrenze bis zum Abstand, bei dem Ladungstrennung erfolgt, ist dafür unabdingbar. Der Elektronentransfer durch die Phasengrenze von Anatas zu Rutil (<10 μm) wurde durch Markieren und Sichtbarmachen der Reduktionsstellen durch Abscheiden von Ag-Nanopartikeln untersucht (siehe Bild).
Relation Between Induced Hyperthyroidism and an Unidentified Chick Growth Factor. (1948)

A thyrotoxic condition in the chick, induced by feeding desiccated thyroid or iodinated casein was effectively counteracted either by supplementing the diet with condensed fish solubles or by the injection of reticulogen.
Dynamics of non-rigid molecules (1984)

The dynamics of the non-rigid cyclopentene molecule have been studied by infrared and Raman spectroscopies. Even though, in the gas state, most of the rotation-vibration spectra exhibit complex structure due to the combinations of the internal vibrations with the ring-puckering mode, it is possible from the liquid state bandshapes to analyze the molecular rotational motion. In particular it is shown that this motion is quasi-diffusional with a diffusion tensor nearly spherical.
Primary Subcutaneous Spindle Cell Ewing Sarcoma with Strong S100 Expression and <i>EWSR1-FLI1</i> Fusion: A Case Report (2014)

Ewing sarcoma is described classically as a small, round cell tumor of bone and soft tissue in children and young adults. Ewing sarcoma most often is characterized by a fusion of the Ewing sarcoma breakpoint region 1 (EWSR1) and the Friend leukemia virus integration 1 (FLI1) genes, forming an EWSR1-FLI1 fusion transcript. We report an exceptional case of primary subcutaneous Ewing sarcoma in a 16-year-old female composed entirely of spindle cells with focal fascicular growth and exhibiting strong, diffuse immunohistochemical reactivity for S100, unlike classic Ewing sarcoma. However, reverse transcription-polymerase chain reaction (RT-PCR) analysis confirmed the presence of a rare variant of the EWSR1-FLI1 fusion transcript, featuring fusion of EWSR1 exon 10 to FLI1 exon 6. To our knowledge, the combined histologic, molecular, and clinical features have not been reported previously in Ewing sarcoma, and raise a broad differential diagnosis emphasizing the importance of molecular techniques in the diagnosis of this tumor.
Biotechnological Production and Bioactivities of Mollisin and Two New, Structurally Related Fungal Naphthoquinone Metabolites (2005)

The antibiotic and fungicidal deuteromycete Mollisia caesia Sacc. was cultivated on a large scale. Mollisin (1; = 8-(dichloroacetyl)-5-hydroxy-2,7-dimethylnaphthalene-1,4-dione) and two new tri- and tetrahalogenated metabolites, mollisin A (2) and mollisin B (3) were isolated from M. caesia. The formation of 2 and 3 indicates that the biosynthesis of these compounds starts from a C(16) polyketide (Scheme). Mollisin (1) shows strong fungicidal activities against Sclerophoma pityophila (Corda) v. Höhn and Heterobasidion annosum (Fr.) Bref., which is one of the most-destructive basidiomycetes in coniferous forests. The metabolites 1-3 possess interesting pharmacological activities in assays in search of anti-inflammatory and antiproliferative drugs.
Reductive amination of glutaraldehyde 2,4-dinitrophenylhydrazone using 2-picoline borane and high-performance liquid chromatographic analysis (2012)

A typical method for the measurement of glutaraldehyde (GLA) employs 2,4-dinitrophenylhydrazine (DNPH) to form GLA-DNPhydrazone derivatives. However, this method is subject to analytical errors because GLA-DNPhydrazone is a quaternary bis-derivative and forms three geometric isomers (E-E, E-Z and Z-Z) as a result of the two C[double bond, length as m-dash]N double bonds. To overcome this issue, a method for transforming the C[double bond, length as m-dash]N double bond into a C-N single bond, using reductive amination of DNPhydrazone derivatives, has been applied. The amination reaction of GLA-DNPhydrazones with 2-picoline borane is accelerated with catalytic amounts of acid and is completed within 10 minutes in the presence of 100 mmol L(-1) phosphoric acid. Reduction of GLA-DNPhydrazone by 2-picoline borane is unique and results in the formation of N-(2,4-dinitrophenyl)-1-piperidinamine (DNPPA). NMR and LC-APCI-MS data confirmed the product identification. DNPPA is very stable and did not change when stored for at least four weeks at room temperature. DNPPA has excellent solubility of 14.6 g L(-1) at 20 °C in acetonitrile. The absorption maximum wavelength and the molar absorptivity of DNPPA were 351 nm and 4.2 × 10(4) L mol(-1) cm(-1) respectively. Complete separation between the reduced forms of C1-C10 aldehyde DNPhydrazones, including DNPPA, can be achieved by operating the reversed-phase high-performance liquid chromatograph at 351 nm in gradient mode using a C18 amide column. The reductive amination method for GLA overcomes analytical errors caused by E-E, E-Z and Z-Z geometrical isomers.
Selective inverse lithography methodology (2010)

Selective Inverse Lithography (ILT) approach recently introduced by authors [1] has proven to be advantageous for extending life-span of lower-NA 193nm exposure tools to achieve satisfactory 65nm contact layer patterning. We intend to find an alternative solution without the need for higher NA tools and advanced light source optimization. In this paper we explore possible region selection criteria for ILT application based on pitch for a full chip optical proximity correction (OPC). Through studying the impact of a given selection criteria on runtime, resolution, and the process window we recommend an optimal combination. With a justified choice of an ILT selection criteria, we construct a hybrid OPC flow comprising a recursive sequence of direct assist features generation, selective ILT application, layout repair, model OPC and hot spots screening.
Biomechanische Testung in der Orthopädie und Wirbelsäulenchirurgie (2015)

Zusammenfassung Seit dem Beginn der neunziger Jahre haben sich die Wissensgebiete der experimentellen Orthopädie und Traumatologie, der Biomechanik und der Biotribologie in großen Schritten weiterentwickelt. Innovative, nachhaltige Produkte oder auch die Neukombination klinisch bewährter Designprinzipien können nur auf Basis tiefgreifender Kenntnisse der Biomechanik, der Biomaterialien und der klinischen Anwendung präklinisch evaluiert werden. Daher erfordert die Entwicklung leistungsfähiger Prüfmethoden zur Charakterisierung neuer Implantatsysteme die enge interdisziplinäre Zusammenarbeit von Implantatentwicklern, Operateuren, Biomechanikern, Biomaterialexperten und Biologen, sowie die aktive Mitarbeit in den internationalen Normungsgremien. Am Beispiel von ausgewählten Fragestellungen mit hoher klinischer Relevanz werden der Stand der Forschung und aktuelle Vorhaben bei der Entwicklung von neuen Prüfverfahren in der Gelenkendoprothetik und Wirbelsäulenchirurgie vorgestellt.
Two-stage linearly-polarized ytterbium-doped fibre superfluorescent source with 106 W output power (2007)

The authors reported a 106 W single-mode, single-ended fibre superfluorescent source with a linearly-polarized output beam based on a simple two-stage configuration comprising a cladding-pumped Yb-doped fibre superfluorescent seed stage and a polarization-maintaining (PM) cladding-pumped Yb-doped fibre amplifier stage. The experimental set-up is shown. The seed-stage comprised a 7-m-long Yb-doped double-clad fibre and a 15 W diode pump source at 915nm. The fibre had a 20-alpham-diameter Yb-doped alumino-silicate core with a numerical aperture (NA) of 0.06, and a pure silica inner-cladding of diameter, 400-alpham.
An examination of various postulates of irreversibility (1977)

These results are compatible with the hypothesis that multiple polyploidization events, possibly enhanced by parthenogenesis, may have driven the evolution of the T. tubifex species complex.
Stability of toxigenicity in proteolytic <i>Clostridium botulinum</i> type B upon serial passage (2012)

Proteolytic Clostridium botulinum type B strains were investigated for stability of toxigenicity and bont/b gene upon serial passage. Strains with bont/b gene located on their plasmids showed loss or decrease of toxigenicity during serial passage. Some strains lost the bont/b gene-encoding plasmid. The stability of the plasmids varied between strains.
A Split Method for Optimized Cost-Quality Hardware Implementation of Lifting-Based Discrete Wavelet Transform (2007)

Discrete wavelet transform (DWT) is increasingly recognized in image/video compression standards, as indicated by its use in JPEG2000. The lifting scheme algorithm is an alternative DWT implementation that has a lower computational complexity. In this paper, a new high performance lifting-based architecture with optimized error vs. hardware complexity is presented for DWT. The proposed architecture modifies the constant coefficients by introducing new variables to the conventional lifting structure to minimize hardware cost and quantization error. In order to achieve the most efficient coefficients, an optimization process has been implemented. Simulation results indicate an average quality improvement of 7.5 dB with the same hardware complexity/cost. Similarly, for achieving the same quality as the conventional hardware implementations the proposed architecture is 20% less complex. The appropriate coefficients can be determined according to the cost and error requirements of each application.
Use and Utility of the Bravo™ pH Capsule (2008)

The single technological advancement that Bravo pH monitoring offers over conventional pH monitoring is the elimination of the transnasal catheter. This was not a trivial advance in terms of technologic achievement. Development of a delivery system that could temporarily place a wireless capsule on the esophageal mucosa was extremely difficult to envision given the fact that the esophageal body is not conducive to retaining a foreign body. Thus, the delivery system and the ability to attach the pH capsule to the wall are what make the Bravo system unique. This approach has the potential to improve tolerance and obtain pH studies for durations greater than 24 hours; however, it still lacks the ability to measure nonacid reflux and also the ability to distinguish swallow events from true reflux. This review will highlight the advantages of the Bravo system and how it should be used.
The influence of the allelophatic interactions between plants. (2012)

This paper provides data regarding the mechanisms developed by plants (based on the biochemical interactions) in order to survive, and the use of these biochemical metabolites in sustainable agriculture systems. The research carried out highlights the effect given by loline alkaloids that were determined in low alcohol extracts of Lolium perenne, on the germination and the growing at the early development stages of the perennial grasses seedlings of Dactylis glomerata, Poa pratensis and Festuca rubra. The material plant used in bioassays consisted of roots, stems, leaves and inflorescence of Lolium perenneculese from the western part of Romania, the Banat region and seeds of Dactylis glomerata, Poa pratensis and Festuca rubra. In order to test the seed germination, the standard method was used. The growth of the embryonic radaciniţelor and tulpiniţelor was determined by biometrizare. The seed germination can be influenced by allelopathic compounds, the allelopathic inhibiting action of the seed germination is more frequent than the stimulation. The tested extracts that were applied in three different concentrations (alkaloids concentrations = 0.668% , dilution I = 0.334%, alkaloids concentrations and dilution II = 0.083%) because the biological activity of the allelophatic compounds is dependent on a characteristics concentration step. The studies on the seed germination ability under the influence of various extracts were made by several researchers which concluded that the direct effect of the allelophatic compounds can be a stimulating effect, but often it is an inhibitory effect. Many cultivated and spontaneous species produce allelochemical compounds that reduce the growth in the seedlings. This phenomenon is mainly due to direct interference with the cell division processes or with the growth hormones. Our studies have shown that allelophatic substances can inhibit the seed germination but can affect the growth and development of the plant receivers of these substances, so that allelophatic phenomenon is a cause-effect relationship between substances with allelophatic potential and physiological response of the target plant. The performed studies results show the following aspect: Lolium perenne extracts present inhibitory allelophatic activity on the seed germination and the application of the extracts doses in different concentrations shows that as the alleophatic substances concentration increase, the inhibitory effect increase; the growth of the plants maintained in an environment treated with extracts, is lower compared to the control sample and the effect is maximal at the highest concentration.