gebhart/patrepeval huggingface dataset:
Oligosubstituted Pyrroles Directly from Substituted Methyl Isocyanides and Acetylenes (2008)

The formal cycloaddition of alpha-metallated methyl isocyanides 1 onto the triple bond of electron-deficient acetylenes 2 represents a direct and convenient approach to oligosubstituted pyrroles 3. The scope and limitations of this reaction (24 examples, 25-97% yield) are reported along with an optimization of the reaction conditions and a rationalization of the mechanism. In addition, a related newly developed Cu(I)-mediated synthesis of 2,3-disubstituted pyrroles by the reaction of copper acetylides derived from unactivated terminal alkynes with substituted methyl isocyanides is described (11 examples, 5-88% yield).
Image segmentation of cribriform gland tissue. (1995)

The automated procedure allows a histometric characterization of premalignant and malignant prostatic lesions. Extension of system capabilities to the utilization of spectral information is expected to allow an increase in the correct segmentation rate.
Fluid shear stress modulates surface expression of adhesion molecules by endothelial cells (1995)

We investigated the effect of hemodynamic shear forces on the expression of adhesive molecules, E-selectin, and intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells (HUVEC) exposed to laminar (8 dynes/cm2) or turbulent shear stress (8.6 dynes/cm2 average), or to a static condition. Laminar flow induced a significant time-dependent increase in the surface expression of ICAM-1, as documented by flow cytometry studies. Endothelial cell surface expression of ICAM-1 in supernatants of HUVEC exposed to laminar flow was not modified, excluding the possibility that HUVEC exposed to laminar flow synthetize factors that upregulate ICAM-1. The effect of laminar flow was specific for ICAM-1, while E-selectin expression was not modulated by the flow condition. Turbulent flow did not affect surface expression of either E-selectin or ICAM-1. To evaluate the functional significance of the laminar-flow-induced increase in ICAM-1 expression, we studied the dynamic interaction of total leukocyte suspension with HUVEC exposed to laminar flow (8 dynes/cm2 for 6 hours) in a parallel-plate flow chamber or to static condition. Leukocyte adhesion to HUVEC pre-exposed to flow was significantly enhanced, compared with HUVEC maintained in static condition (233 +/- 67 v 43 +/- 16 leukocytes/mm2, respectively), and comparable with that of interleukin-1 beta treated HUVEC. Mouse monoclonal antibody anti-ICAM-1 completely blocked flow-induced upregulation of leukocyte adhesion. Interleukin-1 beta, which upregulated E-selectin expression, caused leukocyte rolling on HUVEC that was significantly lower on flow-conditioned HUVEC and almost absent on untreated static endothelial cells. Thus, laminar flow directly and selectively upregulates ICAM-1 expression on the surface of endothelial cells and promotes leukocyte adhesion. These data are relevant to the current understanding of basic mechanisms that govern local inflammatory reactions and tissue injury.
High speed switching measurements in thin film disk media (1998)

Thermal switching has been recognized as a possible limit to archival storage in advanced high density recording media. Thinner films with more isolated grains suffer from large magnetic viscosities /spl sim/10%/decade. Previous work has shown that the observed remanent coercivity H/sub CR/(/spl tau/) in high viscosity tapes can be predicted from Sharrock's Law down to 10/sup -9/s. Here we report high speed switching results on thin film media which show that the remanent coercivity at 10/sup -8/s is increased /spl sim/40% relative to the VSM value in these films. A quantitative relationship between the viscosity, irreversible susceptibility, and the increase in H/sub CR/(/spl tau/) is demonstrated.
Electrogenerated chemiluminescence of naphthalene derivatives. Steric effects on exciplex emissions (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrogenerated chemiluminescence of naphthalene derivatives. Steric effects on exciplex emissionsSu-Moon Park, Mark T. Paffett, and Guido H. DaubCite this: J. Am. Chem. Soc. 1977, 99, 16, 5393–5399Publication Date (Print):August 1, 1977Publication History Published online1 May 2002Published inissue 1 August 1977https://pubs.acs.org/doi/10.1021/ja00458a027https://doi.org/10.1021/ja00458a027research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Use of H19 Gene Regulatory Sequences in DNA-Based Therapy for Pancreatic Cancer (2010)

Pancreatic cancer is the eighth most common cause of death from cancer in the world, for which palliative treatments are not effective and frequently accompanied by severe side effects. We propose a DNA-based therapy for pancreatic cancer using a nonviral vector, expressing the diphtheria toxin A chain under the control of the H19 gene regulatory sequences. The H19 gene is an oncofetal RNA expressed during embryo development and in several types of cancer. We tested the expression of H19 gene in patients, and found that 65% of human pancreatic tumors analyzed showed moderated to strong expression of the gene. In vitro experiments showed that the vector was effective in reducing Luciferase protein activity on pancreatic carcinoma cell lines. In vivo experiment results revealed tumor growth arrest in different animal models for pancreatic cancer. Differences in tumor size between control and treated groups reached a 75% in the heterotopic model (P = .037) and 50% in the orthotopic model (P = .007). In addition, no visible metastases were found in the treated group of the orthotopic model. These results indicate that the treatment with the vector DTA-H19 might be a viable new therapeutic option for patients with unresectable pancreatic cancer.
An environmentally friendly method to prepare gelatine/polyethylene oxide blend membranes for gas separation (2014)

International audience
Acquisition of parasites correlated with social rank and behavioural changes in a fish species (2000)

A survey of parasites was conducted on 258 Symphodus ocellatus (Teleostei: Labridae) collected in Corsica National Park (west Mediterranean). In addition, the total length, sex and social status were recorded for each individual fish. Three species of trematodes were found in the digestive tract. One of the parasites, Genitocotyle mediterranea, was only present, with one exception, in males of large size, and principally in the individuals that had the highest status and that were involved in nest construction. Two hypotheses are suggested to explain this particular distribution of a parasite: the immunocompetence handicap and the changing trophic behaviour as the fish grows.
l1 State Feedback Control of Active Suspension. (2000)

In this paper, the disturbance rejection problem of an automotive active suspension is formulated as an l1 control problem, that is, the minimization of the effects of disturbances in terms of the l∞-induced norm. Since l1 control theory minimizes the maximum possible amplification of signal magnitude, the l1 controller can specify the maximum magnitude of outputs in the time domain, regardless of the frequency of road disturbances. Shamma's l1 near-optimal control theory is applied with a certain approximation. To design a simple static full state feedback controller, a nonlinear controller is designed for a linear active suspension model of a quarter vehicle. Finally, satisfactory performances are confirmed by numerical analysis.
Molecular replacement for nuclear magnetic resonance: application to nmr resonance assignment and protein structure determination (2004)

Our aim is to enhance high-throughput applications of Nuclear Magnetic Resonance (NMR) through the development of efficient computational methods that operate on sparse (minimal) sets of experimental NMR data. We have developed a family of four algorithms for correlating sparse NMR data to 3D structural models in a probabilistic framework. The first two algorithms, Nuclear Vector Replacement (NVR) and NVR via Expectation/Maximation (NVREM), perform automated backbone resonance assignment. The GD and HD algorithms perform 3D Structural homology detection. Our algorithms are computationally efficient, accurate, and require far less experimental data than related methods, making them good candidates for high-throughput applications of NMR.
Final Report: Networks Impacting Solar-Powered Hydrogen Production (2013)

Page Not Found - If you're seeing this page, it's because the URL you requested cannot be located. It might not exist or maybe you mistyped it into your browser. But, if you think it's our mistake, please let us know. Otherwise, you have a few options: try using our navigation bar at the top of this page, visit our home page, or browse our products below. - Homepage Basic Content,
Augmenting the efficacy of antifungal intervention <em>via</em> chemo-biological approaches (2015)

Mycotic infection is becoming a serious health problem since effective antifungal agents for control of pathogenic fungi, especially drug-resistant pathogens, is often very limited. Fungal resistance to antimycotic agents frequently involves mutations caused by environmental stressors. In fungal pathogens, stress signals resulting from oxidative, cell wall stress, etc., are integrated into the upstream mitogen-activated protein kinase (MAPK) pathways that regulate genes countering the stress. Noteworthy is that mutations in MAPK signaling system result in fungal tolerance to cell wall disrupting agents or phenylpyrrole. In a chemo-biological platform to achieve targeted antifungal intervention, the model yeast Saccharomyces cerevisiae served as a tool for identifying mechanisms of actions of redox-active or cell wall disrupting agents. This also enabled the identification of new utility of known compounds or the utilization of natural products/derivatives as chemosensitizing agents to intensify the efficacy of conventional antimycotic agents. Compounds targeting cellular antioxidant, mitochondrial or cell wall integrity systems effectively inhibited the growth of pathogens and/or overcame fungal tolerance to antimycotic agents. Therefore, chemo-biological approaches lead to the development of novel intervention strategies, such as antifungal chemosensitization, which enhance the drug susceptibility of targeted fungi, and ensure the maintenance of healthy microbiome dynamics.
Secure detection with correlated binary sensors (2015)

Sensor networks use binary measurements and state estimations for several reasons, including communication and processing overheads. Such a state estimator is vulnerable to attackers that can hijack a subset of the sensors in an effort to change the state estimate. After exhibiting a simulation that demonstrates the possible effect of integrity cyberphysical systems, this paper extends the authors' methodology for designing the detectors resilient to integrity attacks, using the concept of invariant sets, to systems where the sensor measurements are not independent. In cyberphysical systems, the sensors in question monitor a system constrained to obey physical laws, so that physical quantities measured by and the noise in each sensor will be correlated to the sensors close to it. Further increase in the confidence of the estimate can be achieved by considering these correlations. This paper focuses on modeling the correlation between the sensors and its ramifications on the worst-case probability of detection.
Optical Spectra of Ru4+ in Single Crystals of K2PtCl6 and Cs2ZrCl6 at 4.2°K (1970)

The optical absorption spectra of Ru4+(4d4) has been studied at 4.2°K in single crystals of K2PtCl6 and Cs2ZrCl6. Eight electronic transitions have been observed which have a similar appearance to the spectra of OS4+(5d4) except that the vibrational structure is not as well resolved. An intermediate-coupling crystalfield analysis for a d4 configuration fits the observed electronic transitions with the parameters B = 803 cm−1, C = 1363 cm−1, Dq = 1892 cm−1, and λ4d = 1044 cm−1. The rms deviation of the energies is 262 cm−1. The observed absorptions are assigned on the basis of calculated transition probabilities and energy level diagrams. The relative linewidths are in qualitative agreement with the calculated results for a small tetragonal distortion of the cubic field. The molar susceptibility which is calculated from the optical data is in agreement with the experimental magnetic susceptibility. The calculated g values are tabulated for all the assigned electronic states. A discussion of several unassigned transitions with E &gt; 26 000 cm−1 is given.
Factors Predicting Motor Recovery and Functional Outcome After Traumatic Central Cord Syndrome (2005)

Although the majority of patients improve to an AMS between 90 and 100, many have significant disability and are less functional than the general population. Significant predictive variables include the initial motor score, formal education, comorbidities, age at injury, and development of spasticity. An assessment of more than just the motor score is required to obtain an appreciation of the function and outcomes in this population.
Prenatal diagnosis of monosomy 10q25 associated with single umbilical artery and sex reversal: report of a case (1998)

The association of rare chromosomal rearrangements involving a specific 10q breakpoint with a single umbilical artery (SUA) and sex reversal has never been reported. This report describes the case of a fetus with prenatal ultrasound features of severe intrauterine growth retardation (IUGR), congenital heart disease, and SUA. Fetal blood study revealed de novo deletion of 10q25 and a 46,XY karyotype, while ultrasound demonstrated female genitalia. Based on these findings, sex reversal was diagnosed. Polymerase chain reaction (PCR) amplification revealed the presence of the sex-determining region of the Y (SRY) gene. The pregnancy was terminated at 36 weeks and the newborn weighed 1908 g with marked facial dysmorphism and abnormal genitalia. Because the parents refused autopsy for this case, histopathological examination of gonads was not performed. Breakpoint of the long arm of chromosome 10 may be responsible for sex reversal in the present case and it could thus confirm the concept of autosomal sex reversal proposed in previous reports.
Dephosphorylation of the phosphoprotein P<sub>II</sub> in <i>Synechococcus</i> PCC 7942: identification of an ATP and 2‐oxoglutarate‐regulated phosphatase activity (1997)

The phosphorylation state of the putative signal transduction protein P(II) from the cyanobacterium Synechococcus sp. strain PCC 7942 depends on the cellular state of nitrogen and carbon assimilation. In this study, dephosphorylation of phosphorylated P(II) protein (P[II]-P) was investigated both in vivo and in vitro. The in vivo studies implied that P(II)-P dephosphorylation is regulated by inhibitory metabolites involved in the glutamine synthetase-glutamate synthase pathway of ammonium assimilation. An in vitro assay for P(II)-P dephosphorylation was established that revealed a Mg2+-dependent P(II)-P phosphatase activity. P(II)-P phosphatase and P(II) kinase activities could be separated biochemically. A partially purified P(II)-P phosphatase preparation also catalysed the dephosphorylation of phosphoserine/phosphothreonine residues on other proteins in a Mg2+-dependent manner. However, only dephosphorylation of P(II)-P was regulated by synergistic inhibition by ATP and 2-oxoglutarate. As the same metabolites stimulate the P(II) kinase activity, it appears that the phosphorylation state of P(II) is determined by ATP and 2-oxoglutarate-dependent reciprocal reactivity of P(II) towards its phosphatase and kinase.
Improvements in communication transformers (1935)

The rapidly advancing art of electrical communication and the increasingly wide variety of its applications have required marked improvements in the transformers used in communication circuits. These improvements, achieved partly through advances in design and partly through improvements in the constituent materials, are discussed in this paper.
Comparison of 2 versus 3 dimensional fracture mapping strategies for 3 dimensional computerized tomography reconstructions of scapula neck and body fractures (2017)

Fracture mapping has been used in the understanding of injury patterns in different bones. To our knowledge, there are no applications of this technique using three-dimensional (3D) morphologic fracture characteristics. Previously, scapula fractures were mapped by transferring information from 3D computed tomography to a two-dimensional (2D) template. Cole et al. determined that 3D Computerized Tomography (CT) scans were more reliable compared to plain radiographs in terms of scapular angulation, translation, and glenopolar angle measurements. Thus, we hypothesized that if there is a difference between fracture lines drawn in 3D and in 2D, then the 3D mapping would yield more accurate fracture patterns. We completed a retrospective, comparative study (evidence level III) utilizing CT imaging from a single center scapular registry. We studied ten patients with scapula fractures in whom bilateral CT scans were obtained. Fractures were mapped both two and three-dimensionally, and we measured deviations between the fracture lines that were drawn with each approach. The measured deviations ranged from 10.4 mm to 28.0 mm when comparing 2D versus 3D techniques, with the mean deviation being 4.0 mm and 10.4 mm, respectively. Half of the 2D renderings possessed hidden fracture lines that were later revealed on 3D imaging. Three-dimensional renderings were more accurate when compared to 2D fracture mapping methods. This more accurate technique will allow for better understanding of 3D morphology and provide a basis for future fracture mapping in any bone. Accurate mapping is important because surgical approach, reduction, fixation, and implant design and selection are based on fracture patterns. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:265-271, 2018.
Calculation of Left Ventricular Ejection Fraction of Abnormal Heart in SPECT (2006)

A method is presented for calculation of left ventricular ejection fraction from EKG-gated SPECT images. The method is based on analyzing volumes of ellipsoids fitted to points of maximal activity in the ventricular wall for systole and diastole. This approach differs from methods that rely on defining the inner myocardial wall for systole and diastole either automatically or by hand. The proposed method should be applicable to patients with large perfusion defects. Details of the method are shown using gated SPECT studies of two human subjects.
Providing scalable Web service using multicast delivery (2002)

The recent growth in use of the World-Wide Web in the Internet has caused a significant increase in the demand placed on Web servers. This increased load results in noticeably longer response times for users. We propose an approach to using multicast in the delivery of Web resources that reduces the load on servers as well as the networks that connect them. We analyze the issues involved in using multicast in the Web, especially those related to routing and addressing. We also discuss the design and implementation of a system based on the existing WWW client and server architecture and the multicast support provided within IP.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Leukocyte recruitment in the airways: an intravital microscopic study of rat tracheal microcirculation (2002)

Because of its relative inaccessibility, inflammatory cell extravasation within the airway circulation in vivo has been difficult to investigate in real time. A new method has been established using intravital microscopy in the anesthetized rat to visualize leukocytes in superficial postcapillary venules of the trachea. This technique has been validated using local superfusion of lipopolysaccharide (LPS) and N-formyl-methionyl-leucyl-phenylalanine (FMLP). Basal leukocyte rolling velocity (55.4 +/- 9.3 microm/s) and adhesion (1.4 +/- 0.3 cells/100 microm) were monitored in postcapillary venules (33.9 +/- 1.3 microm diameter). At all time points up to 90 min, these parameters were unaltered in control rats (n = 7). In contrast, vessels exposed to 1 microg/ml of LPS (n = 6) exhibited a 57% reduction in leukocyte rolling velocity and an increase in the number of adherent cells (4.7 +/- 1 cells/100 microm, P < 0.05). Superfusion with 0.1 microM of FMLP (n = 6) also resulted in a 45% reduction in rolling velocity and an increase in adherent cells (4 +/- 0.7 cells/100 microm, P < 0.05). Histological evaluation confirmed local stimulus-induced leukocyte extravasation. These results demonstrate leukocyte recruitment in the airway microvasculature and provide an important new method to study airway inflammation in real time.