gebhart/patrepeval huggingface dataset:
Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole <scp>l</scp> -Riboside with a Unique Mode of Action (2002)

Benzimidazole nucleosides have been shown to be potent inhibitors of human cytomegalovirus (HCMV) replication in vitro. As part of the exploration of structure-activity relationships within this series, we synthesized the 2-isopropylamino derivative (3322W93) of 1H-beta-D-ribofuranoside-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and the biologically unnatural L-sugars corresponding to both compounds. One of the L derivatives, 1H-beta-L-ribofuranoside-2-isopropylamino-5,6-dichlorobenzimidazole (1263W94), showed significant antiviral potency in vitro against both laboratory HCMV strains and clinical HCMV isolates, including those resistant to ganciclovir (GCV), foscarnet, and BDCRB. 1263W94 inhibited viral replication in a dose-dependent manner, with a mean 50% inhibitory concentration (IC(50)) of 0.12 +/- 0.01 microM compared to a mean IC(50) for GCV of 0.53 +/- 0.04 microM, as measured by a multicycle DNA hybridization assay. In a single replication cycle, 1263W94 treatment reduced viral DNA synthesis, as well as overall virus yield. HCMV mutants resistant to 1263W94 were isolated, establishing that the target of 1263W94 was a viral gene product. The resistance mutation was mapped to the UL97 open reading frame. The pUL97 protein kinase was strongly inhibited by 1263W94, with 50% inhibition occurring at 3 nM. Although HCMV DNA synthesis was inhibited by 1263W94, the inhibition was not mediated by the inhibition of viral DNA polymerase. The parent benzimidazole D-riboside BDCRB inhibits viral DNA maturation and processing, whereas 1263W94 does not. The mechanism of the antiviral effect of L-riboside 1263W94 is thus distinct from those of GCV and of BDCRB. In summary, 1263W94 inhibits viral replication by a novel mechanism that is not yet completely understood.
BREAST CANCER STAGING USING Tc-99m SESTAMIBI SCINTIMAMMOGRAPHY (SMM) (1995)

Khalkhali, I.; Cutrone, J.; Mena, I.; Diggles, L.; Venegas, R.; Klein, S. Author Information
Seafloor images and raw context data along AUV track SO239_65-1_AUV6 (Abyss_172) during SONNE cruise SO239 (2017)

The raw images (available on request) have been captured using a Canon 8-15mm fisheye lens and therefore they have a wide field of view, which results in a dark image boundary as the lights did not illuminate the outer sectors well. The images in this dataset have then been undistorted to virtual images that an ideal perspective camera with only 90 degrees horizontal field of view would have seen from the same position. To achieve this, the color of each pixel in the ideal image is obtained by- computing the ray in space associated with this virtual pixel (using rectilinear un-projection)- projecting this ray into the original fisheye image (using equidistant projection), yielding a sub-pixel position- interpolating the colors of the neighboring pixelsTechnically, the undistortion has been performed using the tool https://svn.geomar.de/dsm-general/trunk/src/BIAS/Tools/biasproject.cpp (at revision 418, and earlier, compatible revisions).Manual image annotation is available here: https://annotate.geomar.de/volumes/247
Transmit Weights Optimization for Wireless Cooperative Communications in Rayleigh Fading Channels (2006)

Cooperative communications among the users in the multiple access wireless environments is an efficient way to obtain the powerful benefits of multi-antenna system without the demand for physical arrays. This paper proposes a solution to optimize the weights of partnering user's signal for the minimum error probability at the output of maximum likelihood (ML) detector. Found weights adapt the propagation environment changes and are obtained by taking advantage of the channel state information (CSI) feedback from the receiver to the transmitter. The closed-form BER expressions were also derived and compared to the simulation results to evaluate the suggested method's validity. A variety of numerical results demonstrated the cooperation's superiority over single transmission under flat Rayleigh fading channel plus AWGN (Additive White Gaussian Noise).
PURIFY: a new approach to radio-interferometric imaging (2014)

In a recent paper series, the authors have promoted convex optimization algorithms for radio-interferometric imaging in the framework of compressed sensing, which leverages sparsity regularization priors for the associated inverse problem and defines a minimization problem for image reconstruction. This approach was shown, in theory and through simulations in a simple discrete visibility setting, to have the potential to outperform significantly clean and its evolutions. In this work, we leverage the versatility of convex optimization in solving minimization problems to both handle realistic continuous visibilities and offer a highly parallelizable structure paving the way to significant acceleration of the reconstruction and high-dimensional data scalability. The new algorithmic structure promoted relies on the simultaneous-direction method of multipliers (SDMM) and contrasts with the current major–minor cycle structure of clean and its evolutions, which in particular cannot handle the state-of-the-art minimization problems under consideration where neither the regularization term nor the data term are differentiable functions. We release a beta version of an SDMM-based imaging software written in c and dubbed purify (http://basp-group.github.io/purify/) that handles various sparsity priors, including our recent average sparsity approach sparsity averaging reweighted analysis (SARA). We evaluate the performance of different priors through simulations in the continuous visibility setting, confirming the superiority of SARA.
An HDR (hypoparathyroidism, deafness, renal dysplasia) syndrome locus maps distal to the DiGeorge syndrome region on 10p13/14 (2000)

Partial monosomy 10p is a rare chromosomal condition and a significant proportion of patients show features of DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS). A critical haploinsufficiency region for DGS/VCFS was defined on 10p (DGCR2). We performed molecular deletion analysis of two further patients with partial monosomy 10p, who showed hypoparathyroidism, deafness, and renal dysplasia or renal insufficiency, but no cardiac defect, cleft palate, or reduced T cell levels. Previously, the combination of hypoparathyroidism, deafness, and renal dysplasia has been proposed to represent a specific syndrome (MIM 146255) under the acronym HDR. In addition to the two patients in this report, at least four published cases with partial monosomy 10p show the triad of HDR and 14 other patients present with at least two of the three features. We therefore conclude that HDR syndrome can be associated with partial monosomy 10p. Based on molecular deletion analysis and the clinical data, we suggest that the DGS/VCFS phenotype associated with 10p deletion can be considered as a contiguous gene syndrome owing to haploinsufficiency of two different regions. Hemizygosity of the proximal region, designated DGCR2, can cause cardiac defect and T cell deficiency. Hemizygosity of the distal region, designated HDR1, can cause hypoparathyroidism and in addition sensorineuronal deafness and renal dysplasia/insufficiency or a subset of this triad.
A Genetic Algorithm for Minimizing Delay in Dynamic Overlay Networks (2007)

Overlay multicast is an emerging technology for next generation Internet service to various groups of multicast members. It will take the place of traditional IP multicast which is not widely deployed due to the complex nature of its technology. The overlay multicast which effectively reduces processing at IP routers can be easily deployed on top of a densely connected IP network. An end-to-end delay problem is considered which is serious in the multicast service. To periodically optimize the route in the overlay network and to minimize the maximum end-to-end delay, overlay multicast tree IS investigated with genetic Algorithm. Outstanding experimental results are obtained which IS comparable to the optimal solution and the tabu search.
Chemical Changes in the Aromatic Components of Lubricating Oil Fraction on Hydrotreating (1966)

Chemical changes and reactions in the aromatic components of Kuwait light lubricating oil distillate on hydrotreating were investigated. The original distillate was hydrotreated at 300∼390°C and under constant space velocity using Ni-Co-Mo catalyst. The original distillate and the hydrotreated oils were analysed by the use of low voltage mass spectrometric technique. The results were as follows;(1) The main types of reactions involved in the lubricating oil hydrotreating are the hydrodesulfurization of the sulfur compounds, the partial hydrogenation of the polyaromatic hydrocarbons, the saturation of the monoaromatic hydrocarbons and the hydrocracking of the hydrocarbons. These reactions occur successively in this order.(2) At the moderate temperature next two reactions occured mainly, the hydrogenolysis of the sulfur compounds and the formation of the monoaromatic hydrocarbons caused by the partial hydrogenation of the polyaromatic hydrocarbons. Under these conditions saturated components increased little. And the physical properties of the hydrotreated oil changed not so much, and were proportional to the degrees of hydrodesulfurization.(3) At higher temperature considerable increase in the saturated components were observed according to the saturation of the monoaromatic hydrocarbons and to the hydrocracking of the hydrocarbons. The physical properties of the hydrotreated oils changed markedly under these conditions.(4) The reactivities of the sulfur compounds in the lubricating oil distillate differed little by the types of compounds. It was considered from the changes of the diaromatic hydrocarbons in hydrotreating, that most of the trinuclear aromatic sulfur compounds in Kuwait light lubricating oil distillate were alkylnaphthothiophenes. And alkylthiophenes could not be found in this distillate.
Essential self-adjointness for combinatorial Schrödinger operators III- Magnetic fields (2011)

We define the magnetic Schrödinger operator on an infinite graph by the data of a magnetic field, some weights on vertices and some weights on edges. We discuss essential self-adjointness of this operator for graphs of bounded degree. The main result is a discrete version of a result of two authors of the present paper.
Cognition and game theory in the design of a collaboration manager for shared control of multiple UV assets (2008)

Concurrent requests for assets such as unmanned vehicles (UV) by distributed semi-autonomous teams pose a difficult challenge to coordination and resource optimization. A collaboration management interface system was designed on the basis of a requirements analysis of the UV domain, research findings on group cognition, and concepts from game theory. The system analyzes the joint utility space for concurrent plans, matches them to appropriate game structures, selects an appropriate tactic (centered on information, problem solving, or negotiation), and implements the collaboration scheme in an interface protocol. The methods have considerable promise for coordination of distributed teams in a variety of contexts and for reducing cognitive biases associated with collaboration.
Development on expression of endoglucanases and endoxylanases in transgenic plants (2005)

Non-starch polysaccharides (NSPs) in feeds have been found to be anti-nutritional in monogastric animals. The major anti-nutritional factors are #beta#-glucan and xylan. They can be degraded respectively by #beta#-glucanase and xylanase, and the anti-nutritional factors can be eliminated. Transgenic plants such as tobacco, barley and rice can express the active enzymes from microbes with no disadvantages. Transgenic plants expressing #beta#-glucanase and xylanase can be used directly as feeds or feed additives, substituting for enzymes produced by fermentation. The development of transgenic plants expressing two hydrolytic enzymes were reviewed, and the problems and trends were discussed.
Sequence-nonspecific replication of transfected plasmid DNA in poxvirus-infected cells. (1986)

A system in which transfected plasmid DNA replicates in the cytoplasm of poxvirus-infected cells is described. A variety of recombinant plasmids was introduced into poxvirus-infected cells by transfection, and replication of input plasmid DNA was monitored by (i) digestion with restriction enzymes that discriminate between input methylated plasmid DNA and unmethylated DNA produced by replication in mammalian cells; (ii) amplification of intracellular plasmid DNA; and (iii) density shift analysis in the presence of BrdUrd. Replication of plasmid DNA was observed in the cytoplasm of cells infected with the tumorigenic leporipoxviruses Shope fibroma virus (SFV) and myxoma, and less extensively with the orthopoxvirus vaccinia, but not in uninfected cells. Unexpectedly, all input plasmids tested, including pBR322, pUC13, polyoma, PM2 phi X174 replicative form (RF), and M13 RF, replicated with equal efficiency in SFV-infected cells, indicating that no specific replication origin sequence is required. The transfected plasmid DNA was replicated concomitantly with the infecting poxviral DNA and by 24 hr post-transfection, it resided predominantly in high molecular weight Dpn I-resistant head-to-tail tandem repeats. The failure to detect unreplicated Dpn I-sensitive plasmid concatemers early in replication together with the absence of significant levels of integrated plasmid sequences in the poxviral genome suggest that replication of the transfected plasmid DNA is not the consequence of nonhomologous recombination of concatemeric plasmid DNA into the poxvirus genome, but rather of an autonomous process that is dependent on trans-acting replication factors produced during virus infection, and that does not require a specific origin sequence on the substrate plasmid DNA.
Calculation of Position-Dependent Inductances of a Permanent Magnet Synchronous Machine With an External Rotor by Using Voltage-Driven Finite Element Analyses (2009)

This paper discusses finite element analyses of a skewed permanent magnet synchronous machine (PMSM) with an external rotor regarding the magnetic saliency. Since the machine is fed from a voltage source inverter (VSI), a simulation as close as possible to the regular operational behavior is intended. Therefore, a voltage-driven finite element model with a strong circuit coupling excited with the time-dependent voltages according to the space vectors of the VSI will be applied. This approach directly allows for a comparison of the numerically obtained phase currents with those obtained from measurements. Afterwards, the inductance characteristics depending on the rotor position can be evaluated from the time-dependent phase currents in order to obtain the suitability for a sensorless control algorithm.
The UPS Prototype project: exploring the obstacles in creating a crosse-print archive end-user service (2000)

The Universal Preprint Service (UPS) Prototype was developed in preparation of the first meeting of the UPS initiative - later renamed the Open Archives initiative - held in Santa Fe, New Mexico October 21-22, 1999. The purpose of the meeting was to generate discussion and concensus regarding the interoperability of publicly available scholarly information archives. The invitees represented several renown e-print and report archive initiatives, as well as organizations with an interest in digital libraries and the transformation of scholarly communication. The central goal of the meeting was to agree on recommendations that would make the creation of end-user services - such as scientific search engines, recommendation systems and linking systems - for data originating from distributed and dissimilar archives easier. To facilitate the discussions, the UPS Prototype was constructed as a proof-of-concept of a multi-discipline digital library of publicly available scholarly material. The UPS Prototype harvested its nearly 200,000 records from several different archives and created an attractive end-user environment. As such, the UPS Prototype was a demonstration vehicle for other digital library technologies, such as intelligent digital objects (buckets) and reference linking services (SFX). The paper touches on their applicability in an e-print environment.
Pallidal stimulation in cervical dystonia: clinical implications of acute changes in stimulation parameters (2009)

Frequency and amplitude appear to be the most important factors in the acute anti-dystonic effects in GPi-DBS patients with CD.
Electrochemical/Mechanical Coupling in Ion-Conducting Soft Matter (2015)

Mechanical and electrochemical phenomena exhibit many interesting multidirectional couplings in ion-exchange soft matter due to their intrinsic material physiochemical states and responses to environmental stressors. In this Perspective, such coupling is explored in terms of recent studies with a focus on the degradation of polymer-electrolyte fuel-cell membranes. In addition, (electro)chemical-mechanical coupling of ion-conducting polymers in other applications is also introduced, as there is a research need to explore the interactions between these often wrongly assumed disparate fields in order to optimize, exploit, and discover new technologies and applications.
Improved Threshold Selection by Using Calibrated Probabilities for Random Forest Classifiers (2015)

Random Forest is a well-known ensemble learning method that achieves high recognition accuracies while preserving a fast training procedure. To construct a Random Forest classifier, several decision trees are arranged in a forest while a majority voting leads to the final decision. In order to split each node of a decision tree into two children, several possible variables are randomly selected while a splitting criterion is computed for each of them. Using this pool of possible splits, the Random Forest algorithm selects the best variable according to the splitting criterion. Often, this splitting is not reliable leading to a reduced recognition accuracy. In this paper, we propose to introduce an additional condition for selecting the best variable leading to an improvement of the recognition accuracy, especially for a smaller number of trees. We enhance the standard threshold selection by a quality estimation that is computed using a calibration method. The proposed method is evaluated on datasets for machine learning as well as object recognition.
Preparation and low-voltage mass spectrometry sensitivities of methylated polynuclear aromatic hydrocarbons (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and low-voltage mass spectrometry sensitivities of methylated polynuclear aromatic hydrocarbonsJoseph E. SchillerCite this: Anal. Chem. 1977, 49, 8, 1260–1262Publication Date (Print):July 1, 1977Publication History Published online1 May 2002Published inissue 1 July 1977https://pubs.acs.org/doi/10.1021/ac50016a049https://doi.org/10.1021/ac50016a049research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bildungsweise und Struktur des Pentabromocarbonat‐Anions [[CBr]<sub>n</sub> – Zur Oxidation von Enaminen (1976)

Abstract Bei der Oxidation von Enaminen 5 mit Tetrabrommethan entstehen stabile kristalline Pentabromocarbonate 6 , die sich leicht in die entsprechenden Perchlorate 7 überführen lassen. Aus den Pentabromocarbonaten kann Tetrabrommethan weder durch Extraktion mit organischen Solventien noch durch Erhitzen i. Vak. abgespalten werden, mit Silbernitrat kann jedoch aus Tetraphenylphosphonium‐pentabromocarbonat ( 9 )Silberbromid ausgefällt werden. Bei der Umsetzung von markiertem 9 – dargestellt aus [ 82 Br] Tetraphenylphosphoniumbromid und Tetrabrommethan – mit Silbernitrat findet man die Gesamtaktivität im Silberbromid‐Niederschlag. Dies spricht gegen die Struktur einer trigonalen Bipyramide für das CBr ] n ‐Anion.
Genetic Variation in 11β-Hydroxysteroid Dehydrogenase Type 1 Predicts Adrenal Hyperandrogenism among Lean Women with Polycystic Ovary Syndrome (2006)

Genetic variation in 11beta-HSD1 contributes to enhanced cortisol clearance and compensatory adrenal hyperandrogenism in lean patients with PCOS but may be protective against obesity and some features of the metabolic syndrome.
Quantum cores of optical phase singularities (2004)

The nodal line singularities (optical vortices) of classical scalar optics are smoothed in quantum optics, because of spontaneous emission into unoccupied modes. The radius of the 'quantum core' surrounding each classical singularity is proportional to ??. A trapped excited atom, steered into a nodal line of the classical field, is a possible detector for the effect. Analogous phenomena are anticipated for other waves, for example sound, where the silence at a nodal line is disturbed by pressure fluctuations of the fluid molecules.
Fast steered response power source localization using inverse mapping of relative delays (2008)

The acoustic source localization problem has significance for modern intelligent communication systems and future human-computer interaction applications. Although steered-beamforming localization methods perform well in adverse conditions, the algorithms are inherently computationally burdensome due to their need to search the entire location space. This paper presents a computationally- reduced version of the steered response power (SRP) method. The proposed approach is rooted in the inverse mapping of relative delays to candidate source locations, which allows for the transformation of the iterative search from the multidimensional location space to the one-dimensional relative delay space. By subsetting the set of traversed relative delays to only those that experience a high-level of cross-correlation, the computational load is reduced by up to 90 % without incurring a loss in localization accuracy.