gebhart/patrepeval huggingface dataset:
HIGH EVENING HOME HEART RATE IS AN INDEPENDENT PREDICTOR OF VISCERAL OBESITY IN HYPERTENSIVE PATIENTS: PP.3.102 (2010)

Objective: High heart rate (HR) in hypertensives, either measured in a clinic or out-of-clinic setting (home or ambulatory blood pressure (BP) monitoring), is an important risk factor for cardiovascular morbidity and mortality. The underlying mechanisms are unknown, but sympathetic nerve activation may contribute to it. Obesity, in particular visceral obesity, is associated with sympathetic nerve activation; therefore, we hypothesized that there is a significant association between high HR and visceral obesity in hypertensives. Design: Cross-sectional study. Methods: In 521 treated hypertensives (mean age:63.6 years; 49% men), three home BP measurement were undertaken both in the morning and evening (before sleep) for 14 days. Home BP and HR levels were calculated as the average of the morning and evening BP and HR levels. Visceral and subcutaneous adipose tissue (VAT, SAT) were assessed by abdominal computer tomography. Results: Mean home HR, but not clinic HR, was significantly associated with VAT (R = 0.146, P = 0.001), SAT (R = -0.113, P = 0.010), and the VAT/SAT ratio (R = 0.1811, P < 0.001). Particularly in the evening, the home HR level was significantly associated with VAT and the VAT/SAT ratio (R = 0.221, 0.253, respectively; both P < 0.001). Age and the use of β blockers were negatively associated with the evening HR level, whereas, male gender, daily drinking, current smoking, and type 2 diabetes were positively associated with the evening HR level (all P < 0.01). Multiple regression analysis including these significant covariates showed that both VAT and VAT/SAT ratio were independently associated with the evening HR level (β = 0.116, 0.187, respectively; both P < 0.01). Moreover, a multiple logistic regression analysis revealed that a 10 bpm increase (1SD) in the evening HR level was an independent predictor of an excess amount of VAT (>100cm2) (OR: 1.708; 95% CI: 1.316–2.218; P < 0.001). Conclusion: Our hypertensive patients with high evening home HR level had an excess amount of visceral fat as well as an abnormal fat distribution. Our findings may partly explain the cardiovascular risk of high HR in hypertensives.
Comparison of Emasculation and Nonemasculation for Hybridization of Soybeans<sup>1</sup> (1979)

Emasculation and nonemasculation of the soybean [ Glycine max (L.) Merr.] flower for hybridization were compared for percentage of pollinations that produced a pod (percent success), number of seeds per pod, number of selfed seed, percentage of hybrid seed based on total pollinations, and time required for hybridization. Two persons made pollinations with three sets of parents in each of three Iowa and two Puerto Rico environments. The gene controlling flower and hypocotyl color was used to differentiate hybrid and selfed seed. Average percentage of successful pollinations across environments was significantly greater for nonemasculation (44%) than for emasculation (36%). Average number seeds per pod was similar for the two procedures. The average number of selfed seed was not significantly different for nonemasculation and emasculation. The percentage of hybrid seed based on total pollinations averaged across environments was significantly greater for nonemasculation (94%) than for emasculation (73%). Time saved by not emasculating the female parent permitted at least 10% more flowers to be pollinated per hour than when emasculation was used. Emasculation of soybean flowers prior to pollination is not justified on the basis of these results.
Microstructural Changes in (1-<i>x</i>)Nd<sub>2/3</sub>TiO<sub>3</sub>–<i>x</i>NdAlO<sub>3</sub>System (2004)

Microstructure studies on the (1-x)Nd2/3TiO3–xNdAlO3 (NTNA) system were carried out using transmission electron microscopy. The presence of Nd2Ti2O7 and Nd4Ti9O24 phases in pure Nd2/3TiO3 is confirmed from electron diffraction patterns. At x=0.1, the ordering due to A-site vacancies is confirmed by the presence of antiphase boundaries and (1/2)(100) superlattice reflection. As x increases, the degree of ordering decreases and finally disappears at x=0.7. The tilting of oxygen octahedra is demonstrated by the presence of the ferroelastic domains in the matrix and the (1/2)(111) and (1/2)(110) superlattice reflections in selected-area electron diffraction patterns. In the NTNA system of x=0.1, both the antiphase and inphase tilting of oxygen octahedra are involved; however, in the range of x from 0.5 to 1.0, only the antiphase tilting of oxygen octahedra is observed due to the presence of the (1/2)(111) superlattice reflection and ferroelastic domains. The variations in the measured dielectric properties of NTNA (dielectric constant and Q·f) are consistent with those in the dielectric properties of the (1-x)La2/3TiO3–xLaAlO3 (LTLA) system obtained by Lee et al.
Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells (2003)

Adaphostin (NSC 680410), an analog of the tyrphostin AG957, was previously shown to induce Bcr/abl down-regulation followed by loss of clonogenic survival in chronic myelogenous leukemia (CML) cell lines and clinical samples. Adaphostin demonstrated selectivity for CML myeloid progenitors in vitro and remained active in K562 cells selected for imatinib mesylate resistance. In the present study, the mechanism of action of adaphostin was investigated in greater detail in vitro. Initial studies demonstrated that adaphostin induced apoptosis in a variety of Bcr/abl- cells, including acute myelogenous leukemia (AML) blasts and cell lines as well as chronic lymphocytic leukemia (CLL) samples. Further study demonstrated that adaphostin caused intracellular peroxide production followed by DNA strand breaks and, in cells containing wild-type p53, a typical DNA damage response consisting of p53 phosphorylation and up-regulation. Importantly, the antioxidant N-acetylcysteine (NAC) blunted these events, whereas glutathione depletion with buthionine sulfoximine (BSO) augmented them. Collectively, these results not only outline a mechanism by which adaphostin can damage both myeloid and lymphoid leukemia cells, but also indicate that this novel agent might have a broader spectrum of activity than originally envisioned.
Effect of Polyborate Pre-treatment on the Shear Strength Development of Phenolic Resin to Sitka Spruce Bonds (1993)

Pre-treating the constituents of wood-based composite panels with fungitoxic chemicals prior to lay-up and pressing offers some advantage over post-pressing treatment. Boron is a strong candidate pretreatment chemical for this application but it influences the bonding mechanisms that must occur during hot pressing. In the present study, the effects of boron loading level (A to 15% boric acid equivalent, BAE) on the strength development rates of small phenol formaldehyde-to-wood (sitka spruce) test bonds was investigated. Each bond (15 mm x 15 mm overlap) was formed under pre-selected time (20 to 240s) and temperature (70, 80 or 95 °C) conditions and immediately thereafter tested in shear mode, this enabled three approximately isothermal bond strength development curves to be constructed for each boron loading level investigated. All levels of boron pretreatment hastened initial strength development rates, although levels above 7.5% BAE had diminishing effects on isothermal rates - with possible decreases at very high (15% BAE) levels. Though not exactly reproducing conditions that occur around bonding sites in panels during pressing, the techniques described may aid in our basic Understanding of the mechanisms affected by chemical pretreatment. © Copyright 1993 by Walter de Gruyter
Partial and Double-Array Implantation of the Ossified Cochlea (2008)

These findings suggest that the double array allows for more usable electrodes than in partially inserted cochlear implant. Compared with adults, children with ossified cochlea do well both in partial standard and double-array insertion. Both insertion techniques are safe, with no complications occurring in our patients. Straight and double arrays should be available in the operating suite for any patient in whom suspected cochlear ossification is confronted.
Genome structures, operating systems and the image of the machine (2006)

Many studies are now demonstrating that many gene products are compartmentalized in Bacteria, whether this is related to the organization of the genome is still open to question, but the many new genome sequences recently uncovered, rather than challenging this conjecture, make it all the more intriguing. Furthermore clustering appears not to be restricted to Bacteria but to extend to Eukarya as well (Blumenthal and Gleason, 2003; Lee and Sonnhammer, 2003). Future studies will tell us whether it was worth exploring.
PEPTIDE MAPPING AND EXPRESSION OF KSHV ORF73 (1998)

42 Background: Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a latency-associated nuclear antigen (LANA) that is the basis for several serologic assays including an immunofluorescence (IFA) and a western blot assay. LANA was recently shown to be encoded by open reading frame (ORF) 73. We used peptide mapping to identify immunoreactive epitopes encoded by ORF73. Methods: One hundred seventy one cleavable, biotinylated 17-mers offset by five were synthesized (identical peptides from the repeat region were eliminated). An enzyme-linked immunosorbent assay was performed on each peptide using a panel of human serum. The initial screen, using sera diluted 1:500, identified 38 potential immunoreactive peptides that were subsequently screened using sera diluted 1:40. In addition, full length and truncated (C-terminus) ORF73 were expressed in bacteria, purified over a nickel column, and analyzed by western blot. Results: Peptide mapping identified no single linear epitope in ORF73 which was recognized by most KS patient sera. Twelve peptides were found to be more reactive with KS patient sera than control sera. However, even with combined use of these peptides sensitivity did not reach that seen with current assays (80-90%). Western blot analysis of the full and truncated ORF73 on a panel of sera demonstrated that the full length and truncated proteins are immunoreactive and may serve as potential substrates for serologic assays. Conclusion: LANA immunoreactivity may be due to conformational epitopes despite the IFA and western blot results. Recombinant full-length or truncated LANA are potential serodiagnostic reagents.
Extraction of metal ions from liquid and solid materials by supercritical carbon dioxide (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtraction of metal ions from liquid and solid materials by supercritical carbon dioxideK. E. Laintz, C. M. Wai, C. R. Yonker, and R. D. SmithCite this: Anal. Chem. 1992, 64, 22, 2875–2878Publication Date (Print):November 15, 1992Publication History Published online1 May 2002Published inissue 15 November 1992https://pubs.acs.org/doi/10.1021/ac00046a039https://doi.org/10.1021/ac00046a039research-articleACS PublicationsRequest reuse permissionsArticle Views1134Altmetric-Citations196LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ein katalytischer Zugang zu (<i>R</i>)‐(+)‐Muscopyridin mit integrierter Selbstreinigung (2003)

Durch Integration verschiedener metallkatalysierter Prozesse in eine „Eintopfreaktion“ eröffnet sich ein präzedenzlos kurzer und effizienter Zugang zum natürlich vorkommenden Moschusriechstoff (R)-(+)-Muscopyridin. Besonders bemerkenswert ist dabei, wie sich durch geschickte Kombination von Metathesereaktionen Produktgemische auf chemische Weise selbst reinigen (siehe Schema; OTf=CF3SO3).
Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles (2020)

While vaccine development will hopefully quell the global pandemic of COVID-19 caused by SARS-CoV-2, small molecule drugs that can effectively control SARS-CoV-2 infection are urgently needed. Here, inhibitors of spike (S) mediated cell entry were identified in a high throughput screen of an approved drugs library with SARS-S and MERS-S pseudotyped particle entry assays. We discovered six compounds (cepharanthine, abemaciclib, osimertinib, trimipramine, colforsin, and ingenol) to be broad spectrum inhibitors for spike-mediated entry. This work could contribute to the development of effective treatments against the initial stage of viral infection and provide mechanistic information that might aid the design of new drug combinations for clinical trials for COVID-19 patients.
A wireless embedded sensor architecture for system-level optimization (2002)

Emerging low power, embedded, wireless sensor devices are targeting a wide range of applications, yet have very limited processing, storage, and energy resources. An architecture must be developed that can efficiently meet system demands while simultaneously remaining flexible to application specific optimizations. Analysis of past designs identifies core architectural issues and their impact on system performance. This paper outlines these issues and presents a generalized architecture designed to provide efficient communication mechanisms while allowing for system-level optimizations. The importance of providing a tight coupling between application and communication processing is shown and the tradeoffs associated with virtual versus physical parallelism are investigated. We conclude that a shared controller closely integrated with special-purpose hardware accelerators is the preferred building block for a flexible yet efficient node. A subset of the architecture is implemented using commercial building blocks and shows substantial improvements in communication performance and the ability to perform system-level optimizations that obtain tight synchronization and low power channel monitoring.
Zur Kenntnis der Dihydro‐pyridin‐Verbindungen (1958)

Abstract 2,6‐Dimethyl‐4‐phenyl‐3,5‐dicarbäthoxy‐dihydro‐pyridin (I), die isomeren 1,2,6‐Trimethyl‐4‐phenyl‐3,5‐dicarbäthoxy‐dihydro‐pyridine (II und X), 2,4,6‐Trimethyl‐3,5‐dicarbäthoxy‐dihydro‐pyridin (V), die isomeren 1,2,4,6‐Tetramethyl‐3,5‐dicarbäthoxy‐dihydro‐pyridine (III und XI), 2,6‐Dimethyl‐3,5‐dicarbäthoxy‐dihydro‐pyridin (VI) sowie die isomeren 1,2,6‐Trimethyl‐3,5‐dicarbäthoxy‐dihydro‐pyridine (IV und XII) wurden hergestellt, genau untersucht und ihre Konstitutionsformeln ermittelt. UV.‐ und IR.‐Spektren dieser Verbindungen werden mitgeteilt. Ausserdem wird ein neues N‐Methyl‐dihydro‐nicotinsäureamid beschrieben, in welchem sehr wahrscheinlich das 1,6‐Dihydroderivat vorliegt; für das seit langem bekannte N‐Methyl‐dihydro‐nicotinsäureamid wird daher in übereinstimmung mit anderen Autoren die 1,4‐Dihydrostruktur für wahrscheinlich gehalten.
Definition und Systematik von Stählen (2017)

No AccessHandbuch StahlNov 2017Definition und Systematik von StählenWolfgang BleckWolfgang Bleckhttps://doi.org/10.3139/9783446449626.001SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2017Pages: 1-11Print ISBN: 978-3-446-44961-9eISBN: 978-3-446-44962-6 Copyright & Permissions© 2018 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage (2015)

We describe a novel mechanism through which stress hormones can induce drug resistance to paclitaxel, which may have profound implications for treating drug resistance in patients with TNBC.
Increasing trends in primary NNRTI resistance among newly HIV‐1‐diagnosed individuals in Buenos Aires, Argentina (2013)

Levels of primary NNRTI resistance in Buenos Aires appear to be increasing in the context of a sustained ARV coverage and a high proportion of undiagnosed HIV-positive individuals.
Major affective disorders and schizophrenia: a common molecular signature? (2006)

Psychiatric disorders, including affective disorders (AD) and schizophrenia (SZ) are among the most common disabling brain diseases in Western populations and result in high costs in terms of morbidity as well as mortality. Although their etiology and pathophysiology is largely unknown, family-, twin-, and adoption studies argue for a strong genetic determination of these disorders. These studies indicate that there is between 40 and 85% heritability for these disorders but point also to the importance of environmental factors. Therefore, any research strategy aiming at the identification of genes involved in the development of AD and SZ should account for the complex nature (multifactorial) of these disorders. During the last decade, molecular genetic studies have contributed a great deal to the identification of genetic factors involved in complex disorders. Here we provide a comprehensive review of the most promising genes for AD and SZ, and the methods and approaches that were used for their identification. Also, we discuss the current knowledge and hypotheses that have been formulated regarding the effect of variations on protein functioning as well as recent observations that point to common molecular mechanisms.
Spectral Properties of Cytochrome b-561 and Cytochrome b-565 in Mucidin-Resistant Mutants of Saccharomyces cerevisiae (1981)

The oxidation of NADH in submitochondrial particles isolated from MUC1, MUC2 and MUC3 mucidin-resistant mutants of Saccharomyces cerevisiae is specifically resistant to mucidin. Extra reduction of cytochrome b-565 induced by mucidin is demonstrated in all tested mucidin-resistant mutants. Red shift of cytochrome b-561 is induced by mucidin in two independent MUC3 mutants. In MUC1 and MUC2 mutants, the red shift is not induced by mucidin, while that promoted by antimycin A and 2-n-heptyl-4-hydroxyquinoline N-oxide are normal. It is concluded that the extra reduction of cytochrome b-565 and the red shift of cytochrome b-561 elicited by mucidin can be largely dissociated from the overall inhibition of the electron flow by distinct mucidin-resistant mutations in different exons of the split mitochondrial gene of cytochrome b.
Comparison of models to estimate genetic effects of weaning weight of Angus cattle. (1999)

Weaning weights from nine sets of Angus field data from three regions of the United States were analyzed. Six animal models were used to compare two approaches to account for an environmental dam-offspring covariance and to investigate the effects of sire x herd-year interaction on the genetic parameters. Model 1 included random direct and maternal genetic, maternal permanent environmental, and residual effects. Age at weaning was a covariate. Other fixed effects were age of dam and a herd-year-management-sex combination. Possible influence of a dam's phenotype on her daughter's maternal ability was modeled by including a regression on maternal phenotype (fm) (Model 3) or by fitting grandmaternal genetic and grandmaternal permanent environmental effects (Model 5). Models 2, 4, and 6 were based on Models 1, 3, and 5, respectively, and additionally included sire x herd-year (SH) interaction effects. With Model 3, estimates of fm ranged from -.003 to .014, and (co)variance estimates were similar to those from Model 1. With Model 5, grandmaternal heritability estimates ranged from .02 to .07. Estimates of maternal heritability and direct-maternal correlation (r(am)) increased compared with Model 1. With models including SH, estimates of the fraction of phenotypic variance due to SH interaction effects were from .02 to .10. Estimates of direct and maternal heritability were smaller and estimates of r(am) were greater than with models without SH interaction effects. Likelihood values showed that SH interaction effects were more important than fm and grandmaternal effects. The comparisons of models suggest that r(am) may be biased downward if SH interaction and(or) grandmaternal effects are not included in models for weaning weight.
Autoantibodies in the Diagnosis and Management of Liver Disease (2003)

Autoantibodies are nonpathogenic manifestations of immune reactivity, and they may occur in acute and chronic liver diseases. Autoantibodies may be consequences rather than causes of the liver injury, and they should be regarded as diagnostic clues rather than etiologic markers. Conventional autoantibodies used in the categorization of autoimmune liver disease are antinuclear antibodies, smooth muscle antibodies, antibodies to liver/kidney microsome type 1, antimitochondrial antibodies, and atypical perinuclear anti-neutrophil cytoplasmic antibodies. Ancillary autoantibodies that enhance diagnostic specificity, have prognostic connotation, or direct treatment are antibodies to endomysium, tissue transglutaminase, histones, doubled-stranded DNA, and actin. Autoantibodies that have an emerging diagnostic and prognostic significance are antibodies to soluble liver antigen/liver pancreas, asialoglycoprotein receptor, liver cytosol type 1, and nuclear pore complex antigens. Autoantibodies of uncertain clinical value that remain under investigation are antibodies to chromatin, lactoferrin, and Saccharomyces cervisiae. Continued recognition and characterization of autoantibodies should improve diagnostic precision, provide prognostic indices, and elucidate target autoantigens. These advances may in turn clarify pathogenic mechanisms, facilitate the development of animal models, and generate novel site-specific therapies.
A multivariable adaptive controller for autonomous helicopters (2002)

Control of autonomous helicopters in the presence of environmental and system uncertainties is a challenging task. These uncertainties not only change the dynamics of the system, but also the trim inputs themselves. In the paper, a multivariable adaptive control methodology is proposed that is applicable for general maneuvers with arbitrary speeds and high bandwidth requirements. The control design methodology achieves global stability, and is tested on a high fidelity simulation of an autonomous helicopter. The results indicate a satisfactory tracking performance even as the speeds and bandwidth requirements are increased well beyond hover, and as the parametric uncertainties and nonlinearities were increased to about 20% of their nominal values.
An enhanced Mean-Shift and LBP-based face tracking method (2011)

Face tracking is widely used in many applications. Mean-Shift method is one of the most popular face detection algorithms. In this article, we propose an enhanced version of Mean-Shift face tracking using Local Binary Pattern (LBP) histogram. Simulation results demonstrate that the proposed joint method outperforms both Mean-Shift and LBP histogram methods.
ULCERS 2.1. Venous Ulcer (2005)

The workup of a patient with a nonhealing wound can be complicated and, at times, all consuming. In an effort to be thorough, many unnecessary laboratory and diagnostic tests are frequently ordered. The differential diagnosis of a patient with a leg ulcer includes disease states ranging from common conditions to esoteric syndromes. How can the wound care clinician navigate through this maze and arrive at a timely, accurate, cost-effective diagnosis and treatment plan?