gebhart/patrepeval huggingface dataset:
Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus (2019)

The aim of this study was to evaluate how the cytokine profiles differed between autoantibody based subgroups of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease, characterized by periods of flares (active disease) and remission (inactive disease). The disease can affect many organ systems, e.g., skin, joints, kidneys, heart, and the central nervous system (CNS). SLE patients often have an overproduction of cytokines, e.g., interferons, chemokines, and interleukins. The high cytokine levels are part of the systemic inflammation, which can lead to tissue injury. In the present study, SLE patients were divided into five groups based on their autoantibody profiles. We thus defined these five groups: ANA negative, antiphospholipid (aPL) positive, anti-Sm/anti-RNP positive, Sjögren's syndrome (SS) antigen A and B positive, and patients positive for more than one type of autoantibodies (other SLE). Cytokines were measured using Mesoscale Discovery (MSD) multiplex analysis. On the basis of the cytokine data, ANA negative patients were the most deviating subgroup, with lower levels of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-12/IL-23p40, and interferon gamma-induced protein (IP)-10. Despite low cytokine levels in the ANA negative group, autoantibody profiles did not discriminate between different cytokine patterns.
22. EX VIVO PURGING OF RHABDOMYOSARCOMA CELLS FROM THE BONE MARROW USING MEROCYANINE-540 (MC-540) OR 4-HYDR0PER0XYCYCL0PH0SPHAMIDE (4-HC) (1990)

Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.
Preparation and Utility of 5-β-D-Ribofuranosyl-1H-tetrazole as a Key Synthon for C-Nucleoside Synthesis (1994)

Abstract A synthesis of 5-β-D-ribofuranosyl-1H-tetrazole (2) and 5-β-D-ribo-furanosyl-1,3,4-oxadiazole-2(3H)-one (9) derivatives is described. Ring transformations of 2 have been investigated in an effort to establish the stability of this synthon for further use in dipolar cycloaddition reactions.
Efficient Discovery of Selective Small Molecule Agonists of Estrogen-Related Receptor γ using Combinatorial Approach (2009)

With the goal of discovering a selective agonist of estrogen-related receptor gamma (ERRgamma) with enhanced potency, we designed a series of small-molecule ligands derived from a known ERRgamma agonist, GSK4716, that can substantially potentiate the transcriptional activity of ERRgamma. Individual compounds among a 30-member library of acyl hydrazones were pre-evaluated through in silico docking studies on the receptor cavities of ERRgamma LBDs using X-ray crystal structures cocrystallized with GSK4716 and 4-OHT. This rational approach to achieve the enhanced potency in ERRgamma transcriptional activity with selectivity over ERRalpha/beta enables us to complete the construction of a focused library by carrying out microwave-assisted parallel synthesis with excellent yields and purities. Finally, we identified a more potent ERRgamma agonist, E6, with excellent selectivity over ERRalpha/beta.
MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples (2013)

We have developed a new computational tool called MMAD, which is capable of performing robust tissue microdissection in silico, and which can improve the detection of differentially expressed genes. MMAD software as implemented in MATLAB is publically available for download at http://sourceforge.net/projects/mmad/.
Subspace learning with frequency regularizer: Its application to face recognition (2015)

Subspace learning is an important technique to enhance the discriminative ability of feature representation and reduce the dimension to improve its efficiency. Due to limited training samples and the usual high-dimensional feature, subspace learning always suffers from overfitting problem, which affects its generalization performance. One possible method is to introduce prior information as a regularizer to constrain its solution space. Traditional regularizers are usually designed in spatial domain, which usually make the projection smooth. In this work, we propose a frequency regularizer (FR), which suppresses the high frequency energy so that the smooth priori is incorporated. Two representative supervised subspace methods with frequency regularizer, FR-LDA and FR-SR are introduced and further applied to face recognition problem. Extensive experiments on popular face databases validate the effectiveness and superiority of FR based subspace learning compared to traditional subspace learning methods.
A Convenient Method for Preparations of 1-Acylimidazoles and Carboxamides by Using Novel Imidazolylsilane Derivatives (2005)

Abstract Various imidazolylsilane derivatives were synthesized by a trans-silylation procedure between 1-(trimethylsilyl)imidazoles and chlorosilanes. Among them, tris- and tetrakis(imidazol-1-yl)silane compounds reacted smoothly with free carboxylic acids to form the corresponding 1-acylimidazoles, which subsequently underwent condensation with amines to afford carboxamides in good to high yields. These results indicate that novel reagents containing silicon–imidazole linkage are effectively utilized as dehydrating reagents to form carboxylic acid derivatives from free carboxylic acids and nucleophiles under mild conditions.
The influence on biogas production of three slurry-handling systems in dairy farms (2015)

Handling systems can influence the production of biogas and methane from dairy farm manures. A comparative work performed in three different Italian dairy farms showed how the most common techniques (scraper, slatted floor, flushing) can change the characteristics of collected manure. Scraper appears to be the most <em>neutral</em> choice, as it does not significantly affect the original characteristics of manure. Slatted floor produces a manure that has a lower methane potential in comparison with scraper, due to: a lower content of volatile solids caused by the biodegradation occurring in the deep pit, and a lower specific biogas production caused by the change in the characteristics of organic matter. Flushing can produce three different fluxes: diluted flushed manure, solid separated manure and liquid separated manure. The diluted fraction appears to be unsuitable for conventional anaerobic digestion in completely stirred reactors (CSTR), since its content of organic matter is too low to be worthwhile. The liquid separated fraction could represent an interesting material, as it appears to accumulate the most biodegradable organic fraction, but not as primary substrate in CSTR as the organic matter concentration is too low. Finally, the solid-liquid separation process tends to accumulate inert matter in the solid separated fraction and, therefore, its specific methane production is low.
Some Aspects of Penicillin Production by Aspergillus nidulans (1947)

SUMMARYSUMMARY1. The statement is made that Aspergillus nidulans produces penicillin in both surface and submerged fermentations.2. Evidence for this statement includes: a, inactivation by penicillinase; b, method of extraction; c, inactivation by hydroxylamine; d inactivation by copper sulphate; e, instability at low and high pH; f, solubility in various organic solvents; g, antibacterial activity.3. Of the twenty carbon sources investigated, the whole ground grains supported the best yields. Exclusive of the whole ground grains, lactose and galactose were the best carbon sources. The maximum yield and the time the peak was reached depended upon the concentration of carbon and the amount of aeration. The effect of concentration and aeration varies with the carbon source.4. No substitute as good as corn steep was found. Soy bean meal was the best of the substitutes among the substances investigated. Corn steep at a 4 per cent concentration, when used with a 2 per cent concentration of lactose, supported the highest yields.5. The chemical changes occurring during fermentation were studied.6. The highest yield obtained was equivalent to 20u/ml. of penicillin.
Optically enabled magnetic resonance study of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mmultiscripts><mml:mi mathvariant="normal">As</mml:mi><mml:mprescripts/><mml:none/><mml:mn>75</mml:mn></mml:mmultiscripts></mml:mrow></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mmultiscripts><mml:mi mathvariant="normal">Sb</mml:mi><mml:mprescripts/><mml:none/><mml:mn>121</mml:mn></mml:mmultiscripts></mml:mrow></mml:math>in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mmultiscripts><mml:mi mathvariant="normal">Si</mml:mi><mml:mprescripts/><mml:none/><mml:mn>28</mml:mn></mml:mmultiscripts></mml:mrow></mml:math> (2015)

The electron and nuclear spins of donor impurities in enriched $^{28}\mathrm{Si}$ have great potential as long-lived qubits for a silicon-based quantum information technology. The ability to resolve the hyperfine-split neutral donor ground-state levels in the near-infrared donor bound exciton transitions of the ubiquitous phosphorus impurity in highly isotopically enriched $^{28}\mathrm{Si}$ has led to new methods of hyperpolarizing and measuring the donor electron and nuclear spins. This has resulted in optically assisted magnetic resonance methods that have permitted the measurement of remarkably long nuclear coherence times for both the neutral and ionized phosphorus donor in very lightly doped and highly enriched $^{28}\mathrm{Si}$. Other shallow donors such as arsenic, antimony, and bismuth offer the potential of larger hyperfine couplings and nuclear spins as compared to phosphorus. Here, we investigate whether donor bound exciton transitions can be used to initialize and read out the nuclear spins of arsenic and antimony in $^{28}\mathrm{Si}$. The projective readout of the electron and nuclear spins is demonstrated for both $^{75}\mathrm{As}$ and $^{121}\mathrm{Sb}$, and these optical transitions can strongly hyperpolarize the nuclear spin of $^{75}\mathrm{As}$. Only a small nuclear hyperpolarization is achieved for $^{121}\mathrm{Sb}$, likely due to the relative weakness of the no-phonon transition of the Sb donor bound exciton. Optically assisted EPR and NMR is demonstrated for $^{75}\mathrm{As}$, including Hahn echo coherence time measurements of the six NMR transitions.
NegPar: a parallel corpus annotated for negation (2018)

Although the existence of English corpora annotated for negation has allowed for extensive work on monolingual negation detection, little is understood on how negation-related phenomena translate across languages. The current study fills this gap by presenting NegPar, the first English-Chinese parallel corpus annotated for negation in the narrative domain (a collection of stories from Conan Doyle's Sherlock Holmes). While we followed the annotation guidelines in the ConanDoyleNeg corpus (Morante and Daelemans, 2012), we reannotated certain scope-related phenomena to ensure more consistent and interpretable semantic representation. To both ease the annotation process and analyze how similar negation is signaled in the two languages, we experimented with first projecting the annotations from English and then manually correcting the projection output in Chinese. Results show that projecting negation via word-alignment offers limited help to the annotation process, as negation can be rendered in different ways across languages.
Characterizing the population of pulsars in the Galactic bulge with the $Fermi$ Large Area Telescope (2017)

Abstract Not Provided
Fluorescence of cyclotetrasilanes in rigid glass at 77 K, a remarkably large Stokes shift (1989)

The fluorescence of cyclotetrasilanes with an extremely large Stokes shift (up to 13700 cm–1) has been observed in rigid matrices at 77 K. The large Stokes shift is interpreted in terms of variation in potential energy for the S1 and S0 states as a function of the ring Si–Si bond distance. Fluorescence properties are dependent on the molecular structures (planar and bent forms) of the compounds; the fluorescence quantum yield, lifetime, and Stokes shift for the former are greater than those for the latter.
Restraining False Feedbacks in Peer-to-Peer Reputation Systems (2007)

The efficiency of reputation system depends on the quality of feedbacks. However current reputation models in peer-to-peer systems can not process such strategic feedbacks as correlative and collusive ratings. Furthermore in them there exists unfairness to blameless peers. We propose a new reputation management mechanism to restrain false feedbacks. Our method uses two metrics to evaluate peers: feedback and service trust. After a transaction both service consumer and provider report the quality of this transaction. According to two ratings, service trust of server and feedback trust of consumer are separately updated. Furthermore the former is closely related to the latter. Besides reputation model we also propose a punishment mechanism to prevent malicious servers and liars from iteratively exerting bad behaviors in the system. However under punishment server is only restrained from providing services and it can continuously send out service requests; consumer is restrained from launching requests while it can provide services. Simulation shows our approach can effectively process aforesaid strategic feedbacks and mitigate unfairness.
Studies on Tensile Strength, Heat-Shrinkage Force, and Crystallinity of Rayon Tire Cords and Regenerated Cellulose Films at Elevated Temperatures (1969)

Measurements were made of tensile strength and heat-shrinkage force of rayon tire cords and of ir absorption spectra (unpolarized and polarized) of regenerated cellulose films in D 2 O vapor at elevated temperatures. The changes in crystallinity and frequency of OH absorption bands (intermolecular and intramolecular hydrogen bonding) in the crystalline region with increasing temperatures were determined. The ir absorption spectra of dry, regenerated cellulose films were also measured. The decrease in intermolecular hydrogen-bonding force with increasing temperatures was larger than that in intramolecular hydrogen-bonding force in the crystalline region of regenerated cellulose film. The increase in heat-shrinkage force of dry, rayon tire-cord filaments was related with the decrease in hydrogen bonding force. The decrease in tensile strength of rayon tire cord was correlated with the decrease of ir crystallinity and intermolecular hydrogen-bonding force in the crystalline region of regenerated cellulose film.
Erythropoietin-independent erythroid colonies: is the molecular basis clarified? (2006)

Comment on Garcon et al, page [1551][1] 

In this issue, Garcon and colleagues in Vainchenker's laboratory describe the molecular basis of erythropoietin-independent colonies (also referred to as endogenous erythroid colonies [EECs]) in polycythemia vera (PV).

Garcon and colleagues provide
Effect of Distributed Subcarrier Permutation on Adaptive Beamforming in WiMAX Networks (2008)

In this paper, we investigate the performance of adaptive beamforming while using subcarrier permutation PUSC in WiMAX cellular network. In the literature, it has been shown that frequency reuse 1 is possible for beamforming capable WiMAX networks but with partial resource utilization or base station coordination. In this paper, we show however that using distributed subcarrier permutation (PUSC) offers sufficient diversity to allow full resource utilization without the need of coordination. We study an IEEE 802.16e cellular network employing adaptive beamforming per PUSC Major Group. Performance is evaluated in terms of radio quality parameters and system throughput. Results are based on Monte Carlo simulations performed in downlink. The simulation results show that even with reuse 1 and full load conditions, outage probability can be reduced to an acceptable value.
Tri-band cactus shaped printed monopole (2014)

This paper presents a printed multi-band monopole antenna for use in wireless systems. The antenna is designed to operate at 2.4 GHz, 3.6 GHz, and 5.6 GHz under the maximum return loss of 10 dB. CST Microwave Studio was used for the design process. Chemical etching was used in the fabrication process. The resulting frequency bands cover 2.13-2.48 GHz, 3.51-3.88 GHz, and 5.56-6.70 GHz.
Polysaccharides of Intracrystalline Glycoproteins Modulate Calcite Crystal Growth In Vitro (1996)

Abstract Assemblies of glycoproteins from within the mineralized tissues of sea urchins and mollusks both interact in vitro in a similar manner with growing calcite crystals. A protein‐rich fraction, a polysaccharide‐rich fraction, and a fraction composed of densely glycosylated peptide cores were obtained by chemical and enzymatic treatment of the glycoproteins from sea‐urchin spines. Each fraction was partially purified and characterized (amino acid composition, FTIR and NMR spectroscopy). A comparison of the interactions of these fractions with growing calcite crystals in vitro shows that the polysaccharide moieties of these glycoproteins are intimately involved in the interaction with growing calcite crystals on planes approximately parallel to the c crystallographic axis. Presumably the polysaccharides in the mollusk‐shell glycoproteins are likewise responsible for the similar interactions of these macromolecules with calcite. We suggest that structured polysaccharide moieties of glycoproteins are important in controlling aspects of crystal growth in vivo as well.
Spectral narrowing and stabilization of interband cascade laser by volume Bragg grating (2015)

A volume Bragg grating recorded in photo-thermo-refractive glass was used to spectrally lock the emission from an 18-μm-wide interband cascade laser ridge to a wavelength of 3.12 μm. The spectral width of emission into the resonant mode is narrowed by more than 300 times, and the thermal wavelength shift is reduced by 60 times. While the power loss penalty is about 30%, the spectral brightness increases by 200 times.
The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: A “bumper-car” model (2004)

We propose a conceptual model for the cytoskeletal organization of endothelial cells (ECs) based on a major dichotomy in structure and function at basal and apical aspects of the cells. Intracellular distributions of filamentous actin (F-actin), vinculin, paxillin, ZO-1, and Cx43 were analyzed from confocal micrographs of rat fat-pad ECs after 5 h of shear stress. With intact glycocalyx, there was severe disruption of the dense peripheral actin bands (DPABs) and migration of vinculin to cell borders under a uniform shear stress (10.5 dyne/cm2; 1 dyne = 10 microN). This behavior was augmented in corner flow regions of the flow chamber where high shear stress gradients were present. In striking contrast, no such reorganization was observed if the glycocalyx was compromised. These results are explained in terms of a "bumper-car" model, in which the actin cortical web and DPAB are only loosely connected to basal attachment sites, allowing for two distinct cellular signaling pathways in response to fluid shear stress, one transmitted by glycocalyx core proteins as a torque that acts on the actin cortical web (ACW) and DPAB, and the other emanating from focal adhesions and stress fibers at the basal and apical membranes of the cell.
Phase Lag of Tire Cornering Force (1989)

Abstract Automobile handling can be greatly improved by reducing the phase lag of tire cornering force behind imposed distortion. We have shown experimentally that this lag is related to in‐plane stiffness of the belt and to radial, lateral, and circumferential stiffnesses of the sidewall. While the cornering stiffness is related to the belt rigidity, either can be changed without affecting the sidewall stiffnesses. The cornering stiffness, for example, is sensitive to design factors such as tread compound and tread pattern. The radial, lateral, and circumferential sidewall stiffnesses, however, are mutually perpendicular at a given point in a tire, so they cannot be changed independently of each other. In order to reduce the phase lag of the cornering force, the lateral and circumferential stiffnesses must be increased with a minimum increase in radial stiffness. This can be done by either lowering the radial location of the maximum section width of the inflated tire or by proper changes in material and/or design elements of the sidewall.
A closed-loop control-loading system (1979)

Langley Differential Maneuvering Simulator (DMS) realistically simulates two aircraft operating in differential mode. It consists of two identical fixed-base cockpits and dome projection systems. Each projection system consists of sky/Earth projector and target-image generator and projector. Although programmable control forces are small part of overall system, they play large role in providing pilot with kinesthetic cues.
Photodiode preamplifier systems: low-noise positive-feedback (1977)

Positive feedback circuits have been developed that allow an NEP (1.42, 500, 1) of 10(-14) W Hz(-(1/2)) or better to be achieved for cooled intrinsic germanium photodiodes of up to 6-mm diam. These circuits have also been tested at room temperature with silicon photodiodes and with test capacitors; it is reasonable to suppose that they may be used with other transducers that have a capacitance as their dominant circuit component. Circuits that had one-half-power frequencies of 2-3 Hz with no feedback have routinely achieved bandwidth enhancement factors larger than 400 without degrading the original NEP. The technique is not limited to low frequency.
Vanadyl Chelates of Tetraphenylporphine and its para-Substituted Derivatives (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVanadyl Chelates of Tetraphenylporphine and its para-Substituted DerivativesKeihei Ueno and Arthur E. MartellCite this: J. Phys. Chem. 1956, 60, 7, 934–938Publication Date (Print):July 1, 1956Publication History Published online1 May 2002Published inissue 1 July 1956https://pubs.acs.org/doi/10.1021/j150541a025https://doi.org/10.1021/j150541a025research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts