gebhart/patrepeval huggingface dataset:
Motility Screen Identifies Drosophila IGF-II mRNA-Binding Protein—Zipcode-Binding Protein Acting in Oogenesis and Synaptogenesis (2008)

The localization of specific mRNAs can establish local protein gradients that generate and control the development of cellular asymmetries. While all evidence underscores the importance of the cytoskeleton in the transport and localization of RNAs, we have limited knowledge of how these events are regulated. Using a visual screen for motile proteins in a collection of GFP protein trap lines, we identified the Drosophila IGF-II mRNA-binding protein (Imp), an ortholog of Xenopus Vg1 RNA binding protein and chicken zipcode-binding protein. In Drosophila, Imp is part of a large, RNase-sensitive complex that is enriched in two polarized cell types, the developing oocyte and the neuron. Using time-lapse confocal microscopy, we establish that both dynein and kinesin contribute to the transport of GFP-Imp particles, and that regulation of transport in egg chambers appears to differ from that in neurons. In Drosophila, loss-of-function Imp mutations are zygotic lethal, and mutants die late as pharate adults. Imp has a function in Drosophila oogenesis that is not essential, as well as functions that are essential during embryogenesis and later development. Germline clones of Imp mutations do not block maternal mRNA localization or oocyte development, but overexpression of a specific Imp isoform disrupts dorsal/ventral polarity. We report here that loss-of-function Imp mutations, as well as Imp overexpression, can alter synaptic terminal growth. Our data show that Imp is transported to the neuromuscular junction, where it may modulate the translation of mRNA targets. In oocytes, where Imp function is not essential, we implicate a specific Imp domain in the establishment of dorsoventral polarity.
Excellent two-year survivorship of 3D-printed metaphyseal cones in revision total knee arthroplasty (2020)

Novel 3D-printed titanium cones, with a reamer-based system, yielded excellent early survivorship and few complications in patients with severe bone loss undergoing difficult revision TKA. The diversity of cone options, relative ease of preparation, and outcomes rivalling those of previous designs of cone support their continued use. Cite this article: <i>Bone Joint J</i> 2020;102-B(6 Supple A):107-115.
Vulvar and vaginal atrophy as viewed by the Spanish REVIVE participants: symptoms, management and treatment perceptions (2017)

VVA remains underdiagnosed and undertreated in Spain, despite its high frequency and significant impact on quality of life. Since patient satisfaction with available treatments remains compromised, an effective discussion of symptoms and therapies with doctors would improve its management.
A Cycloaliphatic Epoxy Resin/Anhydride System Usable up to 150°C (1980)

We determined the physical and mechanical properties of a cyloaliphatic epoxy resin that was cured using a liquid anhydride plus 1-methylimidazole as a catalyst. The resin system has a low viscosity and a long gel time, making it suitable for wet filament winding. The system cures at low temperatures (100–120°C) to yield strong, high modulus resins. High glass transition temperatures (>200°C) can be achieved with curing at 150°C. The cost of the resin system is low compared to other elevated-temperature resins. Data on aging at 150°C in air are presented. Erratum to this paper appears in 3(2).
The delta beta crossover region in Lepore boston hemoglobinopathy is restricted to a 59 base pairs region around the 5' splice junction of the large globin gene intervening sequence (1983)

Genomic DNA from a hemoglobin (Hb) Lepore Boston (delta 87 Gln beta 116 His) homozygote of Southern Italian origin has been studied in order to map the fusion point between the delta and beta genes. An Ava II restriction endonuclease recognition sequence, located 12 base pairs (bp) downstream from the 5' end of the beta gene large intervening sequence, has been taken as marker of the beta-like portion of the fusion gene. This site was present even in the delta beta gene, allowing the localization of the crossover area to a 59-bp region extending from the first nucleotide of the Leu codon in position 88 to the 11th nucleotide of the large intervening sequence. The analysis of the DNA restriction polymorphisms in the gamma delta beta globin gene region provides evidence that a single mutational event originated the Lepore delta beta genes, at least in the Italian population.
Electronic structure, antimalarial activity, and phototoxicity of selected quinolinemethanol derivatives and analogs (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structure, antimalarial activity, and phototoxicity of selected quinolinemethanol derivatives and analogsWilliam P. Purcell and K. SundaramCite this: J. Med. Chem. 1969, 12, 1, 18–21Publication Date (Print):January 1, 1969Publication History Published online1 May 2002Published inissue 1 January 1969https://pubs.acs.org/doi/10.1021/jm00301a005https://doi.org/10.1021/jm00301a005research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simple method for camera calibration of roundabout traffic scenes using a single circle (2013)

In this study, the authors present a simple method to estimate intrinsic and extrinsic parameters of the camera for roundabout traffic scenes. Unlike many previous works on camera calibration for roadway scenes by using parallel lines, the proposed work addresses camera calibration for roundabout scenes by using a circle. The proposed method can estimate focal length, pan angle, tilt angle and camera height by matching the ellipse equation extracted from an image with the perspective‐transformed equation of the corresponding real‐world circle. This method requires only one image for camera calibration. The method is validated with real‐world roundabout traffic scenes and the calibration results are reasonably accurate compared with ground truth measurements.
Quantitative investigations of the decay of Kr I resonances: I. Literature discussion and cascade population of the Kr II state (1996)

Absolute values for the energies, natural halfwidths and excitation cross sections for the Kr I resonances and absolute partial widths for the spectator Auger, participator Auger and Auger shake decays of the Kr I and the Kr I resonances into Kr II states have been collected and critically discussed or have been extracted from already published relative literature data. By means of photon-induced fluorescence spectroscopy a cascade population of the Kr II state following the excitation of the Kr I autoionizing resonances was observed and quantified. It is ascribed to a cascade process involving a correlative radiative transition of the type within Kr II. The probability of this process is explained within a very simple final-state configuration interaction calculation.
ChemInform Abstract: Oxidative Dehydrogenation of Ethane and the Coupling of Methane over Sodium Containing Cerium Oxides. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Circulating soluble selectins in Kawasaki disease (1997)

To investigate the significance of circulating adhesion molecules associated with leucocyte-endothelial cell interaction in Kawasaki disease (KD), serum levels of soluble E-, P-, L-selectin (sE-, sP-, sL-selectin), and vascular cell adhesion molecule-1 (VCAM-1) were measured in 16 patients with KD, eight with other febrile diseases, six with Henoch-Schonlein purpura (HSP), and 10 healthy children using an ELISA. Serum sE-selectin levels from patients in the acute phase of KD were significantly higher than from those in other groups (P < 0.01). The levels of sP-selectin in the subacute phase of KD were significantly higher than in other groups (P < 0.01). Serum sL-selectin levels tended to rise in the convalescent phase of KD. There were also significant correlations between sE-selectin levels and C-reactive protein (r = 0.80, P < 0.0001), and between sP-selectin levels and platelet counts (r = 0.57, P < 0.0001) in KD patients. These data indicate that circulating soluble forms of three selectins may have different kinetics during the clinical course of KD, suggesting that they may reflect its inflammatory process.
Chiral Enolate Equivalents (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Refining algorithms with knowledge-based neural networks: improving the Chou-Fasman algorithm for protein folding (1994)

We describe a method for using machine learning to refine algorithms represented as generalized finite-state automata. The knowledge in an automaton is translated into a corresponding artificial neural network, and then refined by applying backpropagation to a set of examples. Our technique for translating an automaton into a network extends the KBANN algorithm, a system that translates a set of propositional, non-recursive rules into a corresponding neural network. The topology and weights of the neural network are set by KBANN so that the network represents the knowledge in the rules. We present the extended system, FSKBANN, which augments the KBANN algorithm to handle finite-state automata. We employ FSKBANN to refine the Chou-Fasman algorithm, a method for predicting how globular proteins fold. The Chou-Fasman algorithm cannot be elegantly formalized using non-recursive rules, but can be concisely described as a finite-state automaton. Empirical evidence shows that the r...
Cooperative Spatial Audio Authoring: Systems Approach and Analysis of Use Cases (2009)

Today's audio production process is highly parallel and segregated. This is especially the case in the field of audio post production for motion pictures. The introduction of spatial audio systems like 5.1, 22.2 or Wave Field Synthesis results in even more production steps, namely the spatial authoring, to accomplish a rich experience for the audience. This paper proposes a system, which enables the audio engineers to work together on the same project. The proposed system is planned to be implemented for an existing spatial authoring software but can be utilized by any other application, which organizes its data in a tree structured way. Three major use cases, i.e. Single User, Work Space and Work Group, are introduced and analysed.
Simulated Tumor-Immunity System Using a Simple Cellular Automaton Model (2006)

This paper builds a kind of immune system model basing on cellular automata method, in order to simulate the immune response to initial stages of tumor growth. We develop a kind of immune-tumor system at the cellular level, based on two-dimensional stochastic discrete cellular automata. The model takes into account the features of the immune response, and describes the interaction between tumor and immune system. And it shows immune cells growth around tumor. We study the normal cellular automata model, and design the evolution growth rules. At last build discrete cellular automata model of tumor-immune system, and simulate tumor-immune system with many number experiments on computer. Via adjusting different parameters of simulating model, the ultimate results indicate the basal behaviors of tumor-immune system exactly.
Content-Based Color Image Retrieval Using Multi-Variate Feature Vectors (2005)

This paper introduces a content-based image retrieval system which utilizes color, spatial frequency, and structural features of an object in the image. The major key color areas are extracted by image segmentation applying Bayesian classifier with k-means starter in CIELAB space and the color similarity is measured by summing up the inter-cluster color distances. The mutual correlations in DCT components are used to discriminate the spatial frequency features that carry textural details. In addition, a structural feature of image is simply characterized by down sampled color mosaic pattern. A target color image is retrieved by searching the image with the maximum similarity by cross correlations in the multi-dimensional feature vector space. Color similarity was indispensable to narrow the reliable candidate for almost all the tested images. Although an appropriate combination of spectral or structural features worked effective to retrieve the image with textural similarity, but we have not any definitive solution to select the frequency region yet. Finally, we report a method for evaluating the performance of our system based on psychophysical experiments using z-score.
Single Crystal Fibers of MGO:LiNbO3 (1990)

Abstract : As optical instruments and devices see a broader and wider use it becomes necessary to increase their efficiency in order to make them more compact and lighter in weight, particularly for space applications. Nonlinear optical devices, such as second harmonic generators and parametric oscilators, will be an important part of this in order to create new wavelengths and tunable sources. If these devices can be made in fiber form, a significant improvement in efficiency will result. It will then be possible to use the efficient semiconductor lasers as a pump in spite of their poor beam quality. We have investigated the growth of Mg:LiNbO3 in fiber form using the laser-heated pedestal-growth technique. We were able to grow fibers of good optical quality without resorting to post-growth processing. However, we did anneal the fibers to improve their mechanical properties. Different techniques were tried to pole the fibers with limited success.
The range of light ions in polymeric resists (1984)

The technique of ion beam lithography coupled with calculations using a Monte Carlo computer program for ion penetration in solids have been used to obtain various range parameters of hydrogen, helium, lithium, beryllium, boron, and carbon ions in polymethyl methacrylate resist. In the experiment, the resist is bombarded with ions and then developed in a 1 : 1 solution of methyl isobutyl ketone and isopropyl alcohol with the developed depth monitored as a function of time. The saturated developed depth is approximated as the mean path length of the ion in the resist. The physical basis of this approximation is discussed. The projected ranges and straggles of the specified ions at energies of 5–300 keV obtained by fitting the experimental data to the total range using a Monte Carlo program are presented. These range data can be used as guidelines to determine the resist mask thickness for ion implantation and for choosing resist thickness in ion beam lithography.
Electrochemical Properties of Fly Ash by Fossil Power Plant Combustion of Oil and Characteristics as Electrode Material in Secondary Battery (1998)

The electrochemical properties of fly ash obtained from combustion of fuel in fossil power plants and their performance as anode material of secondary battery have been investigated. Various fly ash pellets molded at various molding presssure have been used as anode in lithium secondary battery. The best performance was achieved when fly ash pellet molded at pressure of 100kgf/cm2 is utilized, that is, charge capacity of 273Ah/kg and Coulombic efficiency of larger than 95% have been achieved In addition, this battery exhibited good cycling performance. Considering these results, we predicted that utilization of the fly ash as anodematerial and polyaniline conducting polymer as cathode material in a secondary battery will show charge capacity of 101Ah/kg, energy density of 365Wh/kg and Coulombic efficiency of higher than 92%. Potential application of fly ash as anode material in the secondary lithium ion battery seems also to be meaningful from view point of evironmental improvement by reducing harmful waste.
Theory of Functions of a Complex Variable. Volume III. By A. I. Markushevich, trans, by R. A. Silverman. Pp. xi, 360. 104s. (Prentice-Hall Int., London, 1967.) (1970)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Comparing the Hydrogen-Bonding Effect of Brönsted Bases in Solution and When They Are Covalently Bound to the Surface of Glassy Carbon Electrodes in the Electrochemical Behavior of Hydroquinone (2012)

Mono- and dibasic phthalate bases (HP– and P2–) interact with 1,4-hydroquinone (1,4-H2Q) in acetonitrile through hydrogen bonding to form molecular complexes that oxidize at easier (less positive) potentials than pure 1,4-H2Q. The relatively large decrease in the oxidation overpotential for 1,4-H2Q, observed upon introducing these Brönsted bases, is an example of thermodynamic control of a PCET achieved with weak bases. The favoring effect occurs because the bases accept the protons released by 1,4-H2Q during its two-electron oxidation. Similar effects are observed when the phthalate bases were attached to the electrode surface. The hydrogen bonding was verified and measured by determining diffusion coefficients using 1H NMR spectroscopy. The modification of glassy carbon electrodes with phthalate diazonium salts was monitored by X-ray photoelectron spectroscopy. The experimental electrochemical responses by cyclic voltammetry were fitted to simulations following mechanisms previously reported and using the diffusion coefficients determined by 1H NMR.
Cystic tumors of the fetal and neonatal cerebrum: ultrasound and computed tomographic evaluation. (1983)

Three patients (two infants and one fetus) had complex (partially cystic and partially solid) supratentorial tumors involving the brain. The sonographic and computed tomographic appearance in each of these lesions is described and discussed. The cystic component of each lesion was equally well delineated by the two modalities, whereas the peripheral solid component was better defined by contrast-enhanced computed tomographic scans.
Flat-top narrow band optical filter designed by cascading guided-mode resonance elements (2006)

Flat-top narrow band optical spectral response can be shaped by cascading resonant-grating reflectance filters. Theoretical calculation shows that cascading one-pair of wavelength-offset and asymmetrical lines guided-mode resonance elements (GMRE) results in reflectance spectral response with abruptness factor of 1.44, insertion loss ~ 1.2 dB, contrast ratio 8.71 and possible narrow bandwidth of < 3-nm. Flat-top narrow band optical filters are potential candidates for WDM applications.
A case of adenoid squamous cell carcinoma of the tongue (2008)

A rare case of adenoid squamous cell carcinoma of the tongue is reported. A 61-year-old woman with cardiac sarcoidosis was an inpatient at our hospital. She was referred to us because of a white lesion on the tongue. An incisional biopsy was done, and the lesion was diagnosed to be a mucoepidermoid carcinoma. Partial glossectomy was performed with the patient under general anesthesia. Histologically, the surface layer of the neoplasm was squamous cell carcinoma. An adenoid squamous pattern was found in deep layers where pseudoglandular spaces containing exfoliated acantholytic tumor cells were observed. These pseudoglandulae were negative for alcian blue staining, but positive for anti-cytokeratin immunostaining.Consequently, the lesion was diagnosed to be an adenoid squamous cell carcinoma. As of 3 years and 6 months postoperatively, there has been no evidence of recurrence.
[Possibilities of therapeutic applications of neuronal calcium homeostasis]. (1991)

The role of calcium as a second messenger which mediates the transmission of the signal and has an impact on cellular regulation of the majority of organs at all stages of development was confirmed during the past decade. In the submitted review the authors summarize mechanisms by which calcium exerts its regulatory function. At the same time the authors discuss the possible ratio of disorders in the above systems in various diseases in particular those of the central nervous system and possible pharmacotherapeutic interferences at different levels of transmission of the signal mediated by calcium. As in the mentioned area at the clinical level so far mainly calcium channel blockers were used, the authors summarize the use of these substances in the treatment of cerebral ischaemia, migraine, epilepsy and manic-depressive disease.
Automated Next Generation Sequencing Bioinformatics Pipelines for Pathogen Discovery and Surveillance (2017)

Next-generation sequencing (NGS) has become a vital tool in clinical microbiology, with numerous applications in infectious disease diagnostics, outbreak investigations, and public health surveillance. Although the NGS technology enables comprehensive pathogen detection in a relatively short time at a low cost, the enormous amount of genomics data generated creates a critical challenge of effectively organizing, archiving, analyzing, and reporting the results within a clinically relevant timeframe. Automated pipelines provide the first step in standardizing NGS data processing and reporting, thus eliminating the common bottlenecks in bioinformatics analyses, and providing rapid turnaround. Here, we present the Viral NGS Pipeline optimized for identification and whole genome assembly of viruses, and the Bacterial Meningococcus Genome Analysis Platform (BMGAP), designed for genotypic characterization of meningitis pathogens. These respective pipelines have been used to analyze more than 11,000 clinical samples and isolates. The pipelines are deployable on both standalone and cloud-based servers, enabling their accessibility to internal CDC users, as well as external partners, including state public health laboratories and other collaborators worldwide. These automated pipelines have the potential to contribute to the development of unbiased NGS-based clinical assays for pathogen detection that demand rapid turnaround times, and are expected to play a key role in infectious disease surveillance in the future.