gebhart/patrepeval huggingface dataset:
Effect of chronic intermittent immobilization stress on hypophyso-gonadal function of rats (1980)

Abstract. The neuroendocrine mechanisms involved in chronic stress-induced testosterone (T) suppression have been evaluated in adult male rats. In intact animals, restraint applied 6 h daily for 6 days increased plasma corticosterone, decreased significantly T and Prl, and, to a lesser degree, LH levels. In adrenalectomized (adr-x) rats exposed to the same stress regimen, plasma LH and T values were reduced, whereas Prl concentrations were significantly elevated as compared with intact stressed rats. Adrenalectomy alone did not modify basal levels of these hormones. In intact rats, chronic stress did not alter the amount of [ 125 I]iodo-hCG specifically bound to crude testis membrane preparation, or the testicular responsiveness to hCG as measured by T levels 2 h after the injection of hCG (500 IU). In adr-x groups, a significant decrease in binding capacity of [ 125 I]iodo-hCG and no alteration in hCG responsiveness have been observed. From these studies, it appears 1) that plasma T suppression induced by chronic restraint is not initially mediated by a direct action at the testis level as judged by the normal testicular hCG binding capacity and responsiveness to hCG, 2) the sustained endogenous release of glucocorticoid associated with chronic restraint exposure does not play an important role in the decrease of LH and T secretion but could participate in the drop of Prl induced by long-term exposure to stressors, 3) the decrease in LH secretion may be partly responsible for the suppression of T, whereas FSH (on the basis of previous observations) and Prl do not seem to exert a significant role.
Synthesis of pseudo‐peptide analogues of the C‐terminal tetra‐peptide of gastrin and evaluation of their biological activity on acid secretion (1986)

The syntheses of pseudo-tetrapeptides Boc-Trp-psi (CH2-NH)-Met-Asp-Phe-NH2 21 and Boc-Trp-Met-psi (CH2-NH)-Asp-Phe-NH2 20, representing the C-terminal tetrapeptide sequence of gastrin, in which amide bonds were replaced by CH2-NH bond, are described, as well as the syntheses of pseudo-peptide analogues Boc-Trp-psi (CH2-NH)-Nle-Asp-Phe-NH2 16, Boc-Trp-Nle-psi (CH2-NH)-Asp-Phe-NH2 11, and Boc-Trp-Nle-Asp-psi (CH2-NH)-Phe-NH2 5, in which the methionyl residue was replaced by a norleucyl residue. Pseudo-peptides 16 and 21, in which the amide bond between Trp and Met (or Nle) was substituted by a CH2-NH bond, stimulated gastric acid secretion in the rat in vivo. Pseudo-peptides 11 and 20, where the amide bond between Met (or Nle) and Asp was replaced by a CH2-NH bond, did not exhibit any activity on acid secretion in the rat in vivo but were potent inhibitors of pentagastrin-induced acid secretion. Peptides 11, 16, 20 and 21 all recognize the gastrin receptor on a mucosal cell preparation. Pseudo-peptide 5, in which the amide bond between Asp and Phe was replaced by a CH2-NH bond, was a less potent inhibitor of pentagastin-induced acid secretion and had a weaker affinity than the other pseudo-peptides.
Multiple Viewpoints Modeling Of Tabla Sequences. (2010)

[TODO] Add abstract here.
Aerodynamics of economical aircraft flight up to orbit and return (1995)

The Nicolaides-Flyer is an aircraft with a very large all fabric wing having absolutely no rigid members and, thus, is the ultimate in an economical R eusable Launch Vehicle (~~V)since by flying at a wing loading of one in the dense a tmosphere it has a steady state flight velocity less than 5% of current RLV systems and has horsepower and heating requirements less than 1%. Numerous flight tests for the Air Force and hypersonic wind tunnel tests for DARPA have confirmed the flight worthiness of the N-Flyer system for flying up to orbit and return. This aerodynamic performance is reviewed.
Modeling of a Cocurrent Rotary Dryer (2012)

Parametric mathematical models of drying plants include balance equations and correlations that should be adjusted for each case depending on the material to be dried and the installation. In some cases, variable parameters are simplified as constants, providing an inaccurate model. This article presents a model of a cocurrent dryer, showing the process by which it is arrived at, and raises suggestions for some improvements in the determination of the drying rate to obtain a more accurate analytical expression. Preliminary tests are presented that can be performed on the solid material and the model of a pilot plant is validated.
High Spatial Resolution and High Contrast Visualization of Brain Arteries and Veins: Impact of Blood Pool Contrast Agent and Water-Selective Excitation Imaging at 3T (2010)

The utilized sequence with water-selective excitation improved image quality and CNR properties in high spatial resolution imaging of brain arteries and veins. The used blood pool contrast agent improved the CNR only to a minor extent over the extracellular contrast agent.
Aging and Environmental Stress Cracking of PET, Its Copolymers and Blends: Sections 3.2–3.3 (2002)

3.2 Aging under applied stress 3.2.1 Copolymer samples aged under stress 3.2.2 PET homopolymer and PET/PEN blends aged under stress 3.3 Environmental stress cracking 3.3.1 PET homopolymer and copolymers 3.3.2 Oriented PET homopolymer
Nanomechanical resonant structures as tunable passive modulators of light (2002)

We report on the optical parametric excitation of silicon nanomechanical resonant structures. The threshold laser power needed to set these structures into self-oscillation was estimated to be around 70 μW. We measured resonant frequencies of up to 38 MHz by optical excitation; this method should extend to much higher frequencies. Under optical amplification of motion, the spectral response at resonance narrowed to the equivalent of a mechanical quality factor &gt;20 000 at room temperature. These structures act as frequency tunable passive modulators of light, requiring no additional drive.
Practical model of the axial magnetic field in the end region of large turbo-generators (2019)

Purpose The axial magnetic field occurs in the end-region of large turbo-generators is known to induce hot points or voltages between laminations, that may cause insulation breakdown and thus stator faults. Design/methodology/approach It is important to dispose of simple methods for estimating the axial flux rapidly with regard to the operating point of the machine. Findings The authors provide a practical model of the axial magnetic field based on a simplified vector diagram. The parameters required to build the vector composition of the flux densities are assessed with a limited number of finite element method simulations of the whole end-region of the machine. These simulations were validated by an experimental test on a real turbo-generator. Then the axial flux density was simply estimated for various operating points. Originality/value The originality of the paper concerns the practical model of the axial magnetic field based on a simplified vector diagram.
Nondisulfide polymerization of gamma- and beta-crystallins in the human lens. (1984)

The water-soluble 43,000-dalton fraction (WS43) of the human lens has been shown to be heterogeneous. It appears to contain, in addition to actin, components related to the crystallins. Immunoblot reactions indicate that this polypeptide fraction is composed of dimers containing beta- and gamma-crystallin components. It has been estimated that 10-30% of this fraction arises by dimerization of gamma-crystallin. A possible route for the formation of the 43,000-dalton fraction is suggested by the observation that photolysis of gamma-crystallin with light greater than 295 nm leads to polymer formation, including the 43,000-dalton fraction. The polymerization products react with anti-WS43. The results suggest that photochemical reactions may lead to the accumulation of polymers of some of the crystallins with aging of the human lens. Similar covalently linked polypeptides have previously been shown to be present in the high molecular weight aggregates associated with cataract formation.
A Serpentinite-Hosted Ecosystem: The Lost City Hydrothermal Field (2005)

The serpentinite-hosted Lost City hydrothermal field is a remarkable submarine ecosystem in which geological, chemical, and biological processes are intimately interlinked. Reactions between seawater and upper mantle peridotite produce methane- and hydrogen-rich fluids, with temperatures ranging from <40 degrees to 90 degrees C at pH 9 to 11, and carbonate chimneys 30 to 60 meters tall. A low diversity of microorganisms related to methane-cycling Archaea thrive in the warm porous interiors of the edifices. Macrofaunal communities show a degree of species diversity at least as high as that of black smoker vent sites along the Mid-Atlantic Ridge, but they lack the high biomasses of chemosynthetic organisms that are typical of volcanically driven systems.
Numerical simulation of an osteoporotic femur (2008)

Bone remodelling adapts bone geometry and properties under supported loadings. This optimization process is deteriorated by metabolic diseases like osteoporosis which involves femoral neck fractures and implies Total Hip Arthroplasty. Two finite element models are developed to evaluate the stress distribution within osteoporotic human femur bone tissue, and its influence on the stem stability. The geometries of human femur and prosthesis are obtained by helicoid scanner acquisition. The cortical bone was separated from the trabecular bone by apparent density threshold. The results obtained for osteoporotic femur show that the degradation of trabecular architecture causes high stresses in the anteroinferior zone of the cortical bone. For the femur with hip prosthesis, high stresses weak the bone tissue in the lateral zone of the proximal dyaphisis and in the medial zone of the distal part at the end of the stem.
Association of gut microbiota with metabolism in juvenile Atlantic salmon (2020)

The gut microbiome plays a key role in animal health and metabolism through the intricate functional interconnection between the feed, gut microbes, and the host. Unfortunately, in aquaculture, the links between gut microbes and fish genetics and production phenotypes are not well understood.In this study, we investigate the associations between gut microbial communities, fish feed conversion, and fish genetics in the domestic Atlantic salmon. Microbial community composition was determined for 230 juvenile fish from 23 full-sib families and was then regressed on growth, carbon and nitrogen metabolism, and feed efficiency. We only found weak associations between host genetics and microbial composition. However, we did identify significant (p < 0.05) associations between the abundance of three microbial operational taxonomical units (OTUs) and fish metabolism phenotypes. Two OTUs were associated with both carbon metabolism in adipose tissue and feed efficiency, while a third OTU was associated with weight gain.In conclusion, this study demonstrates an intriguing association between host lipid metabolism and the gut microbiota composition in Atlantic salmon. Video Abstract.
The 2016 seismic series in the south Alboran Sea: Seismotectonics, Coulomb Failure Stress changes and implications for the active tectonics in the area (2017)

The Southern Alboran Sea, particularly the area offshore Al Hoceima Bay, presents moderate but continuous seismic activity since the Mw 6.0 1994 Al Hoceima earthquake. The maximum magnitude occurred in the area was a Mw 6.3 earthquake in the 2004 Al Hoceima – Tamasint seismic series. Since then, the seismicity in the Al Hoceima area has been usual, with maximum seismic magnitudes around 4. An increase in the seismic rate was registered during 2015, especially from May, culminating in the seismic series in January 2016. The mainshock occurred on January 25th 2016 with a magnitude Mw 6.3 and it was preceded by a Mw 5.1 foreshock on January 21st. The seismic series took place at the western end of the Alboran Ridge. Towards the northeast the Alboran Ridge bends, and seems to be connected with the NW-SE right-lateral transtensional Yusuf Fault. The recorded seismicity is mainly located in the Alboran Ridge area and along the N-S Al-Idrisi Fault that seems to continue southwards, towards the Al Hoceima Bay. The focal mechanisms calculated previously in the area showed a leftlateral strike-slip faulting with some normal component in the Alboran Ridge; but always within a complex system of diffuse deformation and high rupture type variability. We have used 41 computed focal mechanisms of this seismic series to analyze its seismotectonics and structural characteristics. To group the focal mechanisms we used a clustering algorithm using the spatial distribution of the events and also the type of rupture mechanism. For each cluster we have obtained the composed focal mechanism, associating it to a particular fault or family of structures. We have tested the mechanical compatibility of these structures by Coulomb Failure Stress transfer modeling. The mainshock of the series occurred in the Al Idrisi Fault intersecting the western Alboran Ridge. This event triggered aftershocks and independent series in left-lateral strike-slip faults associated with the Al Idrisi Fault System towards the south, but also in near pure reverse faults in the fault zone bounding the the Alboran Ridge. Both types of faults and rupture-mechanisms coexist, linked mechanically by stress transfer, being coeval the uplift of the Alboran Ridge and its northwestward displacement due to the left-lateral motion of the Al-Idrisi Fault. It is also discussed how the contrasting faulting processes and seismic ruptures are developed in two differentially oriented fault zones in the context the current NW-SE plate convergence between the African and Eurasian plates in the Westernmost Mediterranean.
Model Parameter-based Rate Control Algorithm for Constant Quality Real-Time Video Coding (2008)

In this paper, we propose a rate control algorithm for constant quality real time video coding. To achieve constant quality, previous algorithm exploit mean absolute of difference(MAD) as measure of frame complexity. However, if scene is abruptly changed or if quantization parameter is not constant, encoder produces various output bits with same MAD. Therefore we know that MAD does not appropriately reflect characteristic of frame. To solve this problem, we exploit model parameter as measure of frame complexity. Because model parameter means slope between output bits and MAD, it reflects correctly complexity of frame. And because previous model, R-MAD model, is not considered quantization parameter, as quantization parameter increases or decreases, model parameter of frame also vary. So model parameter obtained using previous model cannot reflect internal characteristic of video. We solve this problem using proposed model, which is considered quantization parameter. Experiment results show that our algorithm provide better performance, in terms of quality smoothness than previous algorithm. Especially, when scene is abruptly changed, our algorithm alleviates quality drop.
<i>In Vivo</i> and <i>In Vitro</i> Analyses of Regulation of the Pheromone-Responsive <i>prgQ</i> Promoter by the PrgX Pheromone Receptor Protein (2012)

Expression of conjugative transfer and virulence functions of the Enterococcus faecalis antibiotic resistance plasmid pCF10 is regulated by the interaction of the pheromone receptor protein PrgX with two DNA binding operator sites (XBS1 and XBS2) upstream from the transcription start site of the prgQ operon (encoding the pCF10 transfer machinery) and by posttranscriptional mechanisms. Occupancy of both binding sites by PrgX dimers results in repression of the prgQ promoter. Structural and genetic studies suggest that the peptide pheromone cCF10 functions by binding to PrgX and altering its oligomerization state, resulting in reduced occupancy of XBSs and increased prgQ transcription. The DNA binding activity of PrgX has additional indirect regulatory effects on prgQ transcript levels related to the position of the convergently transcribed prgX operon. This has complicated interpretation of previous analyses of the control of prgQ expression by PrgX. We report here the results of in vivo and in vitro experiments examining the direct effects of PrgX on transcription from the prgQ promoter, as well as quantitative correlation between the concentrations of XBSs, PrgX protein, and prgQ promoter activity in vivo. The results of electrophoretic mobility shift assays and quantitative analysis of prgQ transcription in vitro and in vivo support the predicted roles of the PrgX DNA binding sites in prgQ transcription regulation. The results also suggest the existence of other factors that impede PrgX repression or enhance its antagonism by cCF10 in vivo.
Passive synthetic aperture radar imaging with single frequency sources of opportunity (2010)

In this paper we consider passive airborne receivers that use backscattered signals from sources of opportunity transmitting fixed-frequency waveforms. Due to its combined passive synthetic aperture and the fixed-frequency nature of the transmitted waveforms, we refer to the system under consideration as Doppler Synthetic Aperture Hitchhiker (DSAH). We present a novel image formation method for DSAH. Our method first correlates the windowed signal obtained from one receiver with the windowed, filtered, scaled and translated version of the received signal from another receiver. This processing removes the transmitter related variables from the phase of the Fourier integral operator that maps the radiance of the scene to the correlated signal. We next use the microlocal analysis to reconstruct the scene radiance by the weighted-backprojection of the correlated signal. This imaging algorithm can put the visible edges of the scene radiance at the correct location, and under appropriate conditions, with correct strength. Additionally, it is an analytic reconstruction technique which can be made computationally efficient. We show that the resolution of the image is directly related to the length of the support of the windowing function and the frequency of the transmitted waveform. The image reconstruction method is applicable with both cooperative and non-cooperative sources of opportunity using one or more airborne receivers. We present numerical simulations to demonstrate the performance of the image reconstruction method and to verify the theoretical results.
MOLECULAR ATTRACTION AND VELOCITY OF REACTIONS (1925)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMOLECULAR ATTRACTION AND VELOCITY OF REACTIONSO. Maass and C. SivertzCite this: J. Am. Chem. Soc. 1925, 47, 12, 2883–2891Publication Date (Print):December 1, 1925Publication History Published online1 May 2002Published inissue 1 December 1925https://pubs.acs.org/doi/10.1021/ja01689a006https://doi.org/10.1021/ja01689a006research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phenotypic characteristics of familial Creutzfeldt‐Jakob disease assoicated with the codon 178<sup>Asn</sup><i>PRNP</i> mutation (1992)

A group of 43 patients from seven families affected by Creutzfeldt-Jakob disease (CJD) with the codon 178Asn mutation of the PRNP amyloid precursor gene is compared to a group of 211 patients with the sporadic form of the disease. As a group, the patients with the codon 178Asn mutation had an earlier age at onset of illness (almost always presenting as an insidious loss of memory), a longer duration of illness, and an absence of periodic electroencephalographic activity. Transmission of disease to primates was accomplished using brain tissue homogenates from 6 of 10 patients, resulting in significantly shorter incubation periods than those due to sporadic CJD inocula. These findings are interpreted and discussed in terms of possible differences in the temporospatial evolution of damage to the brain, and of accelerated induction of polymerized amyloid protein by its mutationally altered template precursor.
Position sensitive single carrier CdZnTe detectors (2002)

Single polarity charge sensing on room temperature semiconductor gamma-ray detectors can be achieved by using the coplanar electrode readout technique. This method can eliminate the hole trapping problem of the wide bandgap semiconductors which are currently available. Previous results on 5 mm cube CZT detectors confirmed that the energy resolution can be dramatically improved compared with that obtained using the conventional readout method. This paper explores the application of this technique to CdZnTe detectors of larger volume, namely 1 cubic cm. In our previous work, we suggested a method to obtain /spl gamma/-ray interaction depth and further progress is reported here. This technique can be used to correct for the electron trapping as a function of distance from the anode. Some characteristics of this method have been studied and its advantages are discussed. The intrinsic position resolution has been analyzed and energy resolutions of less than 2% FWHM at 662 keV were obtained on both detectors tested. Finally, the factors which are inhibiting reaching the statistical limit of CdZnTe detectors have been explored. These results will be of interest in the design of higher performance, portable and imaging-related room-temperature semiconductor /spl gamma/-ray detectors.
Multisession monitor for .NET mobile applications: theory and implementation (2007)

Future mobile platforms will be characterized by pervasive client downloads. Users would like to download new (untrusted) applications on the spot in order to exploit the computational power of their mobile devices to make a better use of the services available in the environment. Such business model is not adequately supported by the current mobile security architecture and our article aims at extending the scope of security monitoring as a viable alternative. Prior work provided solutions to monitoring single instances of applications or to monitor all instances. The novelty of the proposed approach is that it allows to combine the both approaches, an ability that is needed to cope with many realistic policies.
Chapter 9. Gas-phase molecular spectroscopy (1981)

M. T. Macpherson and R. F. Barrow, Annu. Rep. Prog. Chem., Sect. C: Phys. Chem., 1981, 78, 221 DOI: 10.1039/PC9817800221