Direct Evidence of Facilitative Actions of Dopamine in the Medial Preoptic Area on Reflexive and Noncontact Erections in Male Rats (2003)

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Jan 2003Direct Evidence of Facilitative Actions of Dopamine in the Medial Preoptic Area on Reflexive and Noncontact Erections in Male Rats HIDEKI ADACHI, YOSHIKAZU SATO, RYUICHI KATO, SHINICHI HISASUE, KAZUHIRO SUZUKI, NAOYA MASUMORI, NAOKI ITOH, and TAIJI TSUKAMOTO HIDEKI ADACHIHIDEKI ADACHI , YOSHIKAZU SATOYOSHIKAZU SATO , RYUICHI KATORYUICHI KATO , SHINICHI HISASUESHINICHI HISASUE , KAZUHIRO SUZUKIKAZUHIRO SUZUKI , NAOYA MASUMORINAOYA MASUMORI , NAOKI ITOHNAOKI ITOH , and TAIJI TSUKAMOTOTAIJI TSUKAMOTO View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64133-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We examined the effects of alterations of the extracellular dopamine level in the medial preoptic area on 2 erectile contexts, namely reflexive and noncontact erections, in male rats. Materials and Methods: The extracellular dopamine level was measured in the medial preoptic area after administering the dopamine reuptake inhibitor bupropion hydrochloride (Sigma Chemical Co., St. Louis, Missouri) into the same area through a micro-dialysis tube. We measured the frequency and latency of reflexive erections, and the frequency of noncontact erection during infusion of bupropion. Results: Administration of 10 mM. bupropion was associated with significant elevation in the extracellular dopamine level in the medial preoptic area. Bupropion (1 mM.) and Ringer's solution did not induce significant alterations in dopamine in the medial preoptic area. The number of reflexive erections significantly increased and erection latency decreased during infusion of 10 mM. bupropion into the medial preoptic area. The number of noncontact erections was also increased by administering 10 mM. of drug. 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Google Scholar From the Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 169Issue 1January 2003Page: 386-389 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsdopaminepreoptic areapenisratspenile erectionMetricsAuthor Information HIDEKI ADACHI More articles by this author YOSHIKAZU SATO More articles by this author RYUICHI KATO More articles by this author SHINICHI HISASUE More articles by this author KAZUHIRO SUZUKI More articles by this author NAOYA MASUMORI More articles by this author NAOKI ITOH More articles by this author TAIJI TSUKAMOTO Requests for reprints: Department of Urology, Sapporo Medical University School of Medicine S1, W-16, Chuo-Ku, Sapporo 060, Japan. More articles by this author Expand All Advertisement PDF downloadLoading ...