gebhart/patrepeval huggingface dataset:
Field-induced charge-density-wave deformations and phase slip in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">NbSe</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1993)

We report x-ray diffraction measurements of the effects of electric fields on charge-density-wave (CDW) structure in ${\mathrm{NbSe}}_{3}$. For fields exceeding the CDW depinning field ${\mathit{E}}_{\mathit{T}}$, the (0 1+Q 0) CDW superlattice peak shifts along ${\mathit{b}}^{\mathrm{*}}$. The shift increases rapidly with decreasing temperature, is largest near the electrical contacts, and is in opposite directions in the two halves of the crystal. We show that the observed CDW deformations are consistent with those required for phase slip and CDW-to-normal carrier conversion at the contacts. From the magnitude of these deformations, we determine the CDW elastic constant.
Low-fidelity location based information systems (2004)

In this article, we describe the intrinsic constraints of mobility and discuss how we can work around and often exploit these constraints using information implied by the context of the mobile user. In particular, we outline some of the work we have been doing in providing information to users on the basis of "Low-Fi" location information retrieved from user's cellular phone. A user's location and other contextual information is used to retrieve task relevant information and avoid many of the problems posed by limits of mobile devices and their use. This is part of an ongoing effort to build "smart" navigational interfaces bound on information about a user's location.
Pioglitazone Inhibits LOX-1 Expression in Human Coronary Artery Endothelial Cells by Reducing Intracellular Superoxide Radical Generation (2003)

These observations suggest that the PPAR-gamma ligand pioglitazone reduces intracellular superoxide radical generation and subsequently reduces the expression of transcription factors, expression of the LOX-1 gene, and monocyte adhesion to activated endothelium. The salutary effect of PPAR-gamma ligands in atherogenesis may involve the inhibition of LOX-1 and the adhesion of monocytes to endothelium.
Effective Flow Filtering for Botnet Search Space Reduction (2009)

The use of sophisticated techniques is essential to detect and identify the presence of botnet flows, but these techniques can be expensive in computational and memory resources. A critical first pass is to filter out all traffic that is highly unlikely to be part of a botnet, allowing the more complex algorithms to run over a much smaller set of flows. This paper presents our studies and experience in filtering flows to reduce the botnet search space, and shows that a series of simple filters can provide as much as a 37-fold reduction in the flow set.
Advanced 100V, 0.13 gm BCD process for next generation automotive applications (2006)

A-BCD is a family of advanced 100V BCD processes on SOI (van der Pol, 2000) offering improved robustness, superior EMC performance, extremely high packing density, high temperature operation and easy to design over bulk based technology. In this family a wide range of passive and active devices (up to 100V) are available. This paper describes the design of the latest generation of this family. HV devices on SOI are combined with a deep submicron based CMOS process. This enables the monolithic integration of microprocessors, flash memory, RAMs and ROMs together with power transistors. For automotive applications this monolithic approach guarantees the extremely high quality levels at an economical price level. Also other application areas, par example medical has benefit from this development
Experimentelle Untersuchungen über die Coronardurchblutung und Herzenergetik unter Herzglykosiden und Purinderivaten (1956)

Die bisherigen Vorstellungen über die Regulation der Coronardurch-blutung und ihre pharmakologische Beeinflußbarkeit beruhen auf Untersuchungsergebnissen, die größtenteils unter unphysiologischen Bedingungen erhalten wurden (Langendorfherz, Herzlungenpräparat in verschiedenen Modifikationen). Auch bei der Sondierung des Sinus coronarius mit der Morawitzkanüle durch das rechte Herzohr am Ganztier mit eröffnetem Thorax kommt es in der Regel zu Blutdruckabfall und Minderung der Herzleistung. Die schonende Stickoxydulmethode erlaubt hingegen keine fortlaufende Registrierung, gibt nur Mittelwerte über 10 Minuten und gestattet in 30 Minuten nur zwei Bestimmungen.
African swine fever. II. Detection of the virus in swine tissues by means of the modified direct complement-fixation test. (1967)

The modified direct complement-fixation test, supplemented with unheated normal calf serum, was used to demonstrate antibodies in sera of swine immunized to African swine fever virus. These antibodies did not react in the ordinary direct non-supplemented complement-fixation test.African swine fever complement-fixing antigen in infected swine tissue is not denatured by extraction with fat solvents. Consequently, good antigens devoid of non-specific reactivity were obtained by extraction with a mixture of acetone and ether. The virus was detected in infected swine tissue harvested one day after beginning of pyrexia. The modified direct complement-fixation test demonstrated cross-reactions between the six strains of virus studied.
Using diffuse field interferometry for structural and material characterization in complex aircraft structures (2009)

Structural health monitoring (SHM) systems often rely on propagating elastic waves through complex structures, which can result in the formation of diffuse-fields. Diffuse fields fill the whole structure with energy and are characterized by energy equi-partition among all propagation modes. Due to their apparent complexity, diffuse-fields are not commonly used by conventional SHM systems. However, recent theoretical and experimental studies have demonstrated that the local Green's functions (GF) can be estimated from the cross-correlation of diffuse wavefields recorded between points of a sensor grid and generated by sources located remotely from the monitoring area. The Diffuse Field Interferometry (DFI) concept yields the GF between all measured points (e.g. nominal response of the structure), effectively transforming each measurement point into a virtual source. The resulting local GFs provide detailed information on the dynamic behavior of the material/structure under investigation. In this work, Green's functions are estimated experimentally from DFI using full-field measurements obtained with a scanning laser vibrometer.
Polarization and temperature dependence of photosensitivity in Ge-doped optical fibers (1994)

Permanent photoinduced index change in Ge-doped optical fibers has been used for a few years for writing Bragg gratings by using either UV light1 or blue–green light.2 The internal writing of Bragg gratings by using the two-photon absorption of light around 500 nm has been done only with the technique introduced by Hill et al.2 We present a new technique that uses the interference of two counterpropagating short pulses of green light to write a confined fiber grating.
The Response of the Seated Human to Sinusoidal Vibration and Impact (1987)

Low back pain has been shown to occur more frequently among vehicle drivers than in representative control groups. Thus the response of the human to vibration and impact is of interest. This study investigated the response of the spine to both impact and sinusoidal excitation in either a relaxed or erect seated posture. The sinusoidal testing apparatus used was a resonating system consisting of two parallel wooden beams, simply supported, and the impact testing apparatus a bearing-guided, spring-suspended platform, struck from below. Ten subjects (5 males, 5 females) were evaluated using both methods. Transfer functions were compared at 2-4 Hz, 4-8 Hz and 8-16 Hz intervals using a sign test. Although in 24 comparisons of either test method (vibration or impact) or posture (erect or relaxed) where eleven showed differences significant at the p less than .05 level, only 2 out of 24 comparisons were the differences distinct enough to be significant (at the p less than .01 level). Both of these latter differences were due to test method while the subjects were sitting erect. In those instances where there were no significant differences due to test method, the impact method may be a viable replacement for the vibration test method. Where the levels of significance are higher (p less than .01 or p less than .05), further study of the magnitude of the differences is indicated and may reveal further insight into the seated individual as a system.
Automated sample deoxygenation for improved luminescence measurements (1987)

Quenching of luminescence by molecular oxygen Is an Inherent limitation In fluorescence and phosphorescence analysis. Consequently, greater analytical sensitivity, as well as lower detection limits, can be achieved by removal of oxygen from the sample prior to luminescence analysis. An automated system for rapid deoxygenation Is described In this paper. This apparatus combines a multiple sampling valve and a membrane barrier to generate a concentration gradient for sample deoxygenation. This automatic, multisample, on-line deoxygenation technique reduces sample handling to a minimum because deoxygenation and luminescence analysis occur within a closed system. The usefulness of this procedure Is discussed In terms of automation, reproducibility, detection limit, deoxygenation efficiency, and applications to a variety of compounds. In addition, potential application of this procedure to other analytical subdsciplines Is also discussed. © 1987, American Chemical Society. All rights reserved.
A Novel Leucine Zipper Targets AKAP15 and Cyclic AMP-dependent Protein Kinase to the C Terminus of the Skeletal Muscle Ca2+ Channel and Modulates Its Function (2002)

In skeletal muscle, voltage-dependent potentiation of L-type Ca(2+) channel (Ca(V)1.1) activity requires phosphorylation by cyclic AMP-dependent protein kinase (PKA) anchored via an A kinase-anchoring protein (AKAP15). However, the mechanism by which AKAP15 targets PKA to L-type Ca(2+) channels has not been elucidated. Here we report that AKAP15 directly interacts with the C-terminal domain of the alpha(1) subunit of Ca(V)1.1 via a leucine zipper (LZ) motif. Disruption of the LZ interaction effectively inhibits voltage-dependent potentiation of L-type Ca(2+) channels in skeletal muscle cells. Our results reveal a novel mechanism whereby anchoring of PKA to Ca(2+) channels via LZ interactions ensures rapid and efficient phosphorylation of Ca(2+) channels in response to local signals such as cAMP and depolarization.
A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity (2007)

Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the EHV-1 DNA polymerase (N752/D752) is significantly associated with the neuropathogenic potential of naturally occurring strains. To test the hypothesis that this single amino acid exchange by itself influences neuropathogenicity, we generated recombinant viruses with differing polymerase sequences. Here we show that the N752 mutant virus caused no neurologic signs in the natural host, while the D752 virus was able to cause inflammation of the central nervous system and ataxia. Neurologic disease induced by the D752 virus was concomitant with significantly increased levels of viremia (p = 0.01), but the magnitude of virus shedding from the nasal mucosa was similar between the N752 and D752 viruses. Both viruses replicated with similar kinetics in fibroblasts and epithelial cells, but exhibited differences in leukocyte tropism. Last, we observed a significant increase (p < 0.001) in sensitivity of the N752 mutant to aphidicolin, a drug targeting the viral polymerase. Our results demonstrate that a single amino acid variation in a herpesvirus enzyme can influence neuropathogenic potential without having a major effect on virus shedding from infected animals, which is important for horizontal spread in a population. This observation is very interesting from an evolutionary standpoint and is consistent with data indicating that the N752 DNA pol genotype is predominant in the EHV-1 population, suggesting that decreased viral pathogenicity in the natural host might not be at the expense of less efficient inter-individual transmission.
RESISTANCE TO 6-MERCAPTOPURINE: II THE SYNTHESIS OF THIOINOSINATE IN A 6-MERCAPTOPURINE-RESISTANT SUBLINE OF THE EHRLICH ASCITES CARCINOMA (1962)

An assay for the synthesis of thioinosinate by the nucleotide pyrophosphorylase reaction in tissue extracts has been developed and has been applied in a comparison of the Ehrlich ascites carcinoma and a 6-mercaptopurine-resistant subline. Previously, it was shown that intact Ehrlich cells accumulated substantial amounts of thioinosinate in the presence of 6-mercaptopurine, whereas cells of this resistant subline contained only minor amounts of the analogue nucleotide under the same circumstances. In the present study, it was found that extracts of the two cell types had a similar capacity for the pyrophosphorolytic synthesis of thioinosinate. These results have been interpreted to mean that the transport of 6-mercaptopurine across the cell membrane was defective in the resistant subline.
Study of the Flow Turning Loss in a Simulated Solid Rocket Motor (1995)

The flow turning loss, one of the processes that damp instabilities in solid rockets, is caused by the interaction of the axial acoustic field in an unstable motor with the flow of combustion products from the propellant surface. While state-of-the-art stability models generally account for the flow turning loss, its characteristics have never been fully investigated. In order to study the contribution of the flow turning loss to acoustic stability, a onedimensional acoustic stability equation that includes the flow turning loss term was derived, providing the theoretical background and expressions needed to guide an experimental study. Experiments were performed to determine the dependence of the flow turning loss upon the injection and mean-flow Mach numbers and the location of the flow turning region relative to the standing acoustic wave. These studies showed that the flow turning loss strongly depends upon the magnitude of the gas velocity at the propellant surface and the location of the flow turning region relative to the standing pressure wave. A simple numerical simulation of the experimental setup was developed and its predictions were found to agree well with the measured data. Nomenclature a = speed of sound E~ = quantity representative of the total acoustic energy in the cavity H = height of two-dimension al duct used in analysis hT = total specific enthalpy i = unit vector in the axial x direction j = unit vector in the transverse y direction L = length of duct m = mass flux rate u = axial, x direction, component of velocity V = velocity vector v = transverse, y direction, component of velocity Subscripts b = value at side wall t = average over time y = average over the y direction 0,1,2 = acoustic order
A comparative review of knowledge structure measurement techniques for interface design (1993)

Recent research suggests that the structure of user knowledge, in addition to the content, is a significant determinant of user behavior in computer‐oriented tasks. The purpose of this article is to provide the researcher in human‐computer interaction with a comparative review of available knowledge structure measurement techniques and to summarize their potential application for aiding the designer at various stages of interface design. Three general classes of techniques are identified: verbal reports, clustering, and scaling. Each group is reviewed according to (1) the manner in which concepts and relationships are elicited, (2) the method used to derive the knowledge structure, and (3) procedures used to analyze the knowledge structure. With this information, the human‐computer interface designer can more effectively use these techniques for their particular application.
Biosynthesis of boromycin (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of boromycinTom S. S. Chen, Ching-Jer Chang, and Heinz G. FlossCite this: J. Org. Chem. 1981, 46, 13, 2661–2665Publication Date (Print):June 1, 1981Publication History Published online1 May 2002Published inissue 1 June 1981https://pubs.acs.org/doi/10.1021/jo00326a010https://doi.org/10.1021/jo00326a010research-articleACS PublicationsRequest reuse permissionsArticle Views486Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular dynamics of the <scp>P</scp> 450cam– <scp>P</scp> dx complex reveals complex stability and novel interface contacts (2014)

Cytochrome P450cam catalyzes the stereo and regiospecific hydroxylation of camphor to 5-exo-hydroxylcamphor. The two electrons for the oxidation of camphor are provided by putidaredoxin (Pdx), a Fe2 S2 containing protein. Two recent crystal structures of the P450cam-Pdx complex, one solved with the aid of covalent cross-linking and one without, have provided a structural picture of the redox partner interaction. To study the stability of the complex structure and the minor differences between the recent crystal structures, a 100 nanosecond molecular dynamics (MD) simulation of the cross-linked structure, mutated in silico to wild type and the linker molecule removed, was performed. The complex was stable over the course of the simulation though conformational changes including the movement of the C helix of P450cam further toward Pdx allowed for the formation of a number of new contacts at the complex interface that remained stable throughout the simulation. While several minor crystal contacts were lost in the simulation, all major contacts that had been experimentally studied previously were maintained. The equilibrated MD structure contained a mixture of contacts resembling both the cross-linked and noncovalent structures and the newly identified interactions. Finally, the reformation of the P450cam Asp251-Arg186 ion pair in the MD simulation mirrors the ion pair observed in the more promiscuous CYP101D1 and suggests that the Asp251-Arg186 ion pair may be important.
A developmentally regulated trans-acting factor recognizes dissimilar G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes. (1990)

Transcriptional response elements involved in the cAMP-inducible and developmentally regulated expression of the Dictyostelium aggregate-stage gene pst-cath/CP2 have been shown to include a G/C-rich sequence element [G-box regulatory element (GBRE)]. We have recently identified a trans-acting factor, GBF (GBRE binding factor), that specifically interacts with this sequence and have shown that the binding activity of GBF to GBRE is developmentally regulated and inducible by cAMP. Here, we examine further the possible role of GBF in the regulation of pst-cath/CP2 and three other coordinately regulated, cAMP-inducible aggregate-stage genes. We show that GBF itself (or other closely related factors) recognizes dissimilar G/C-rich elements present in the 5'-flanking regions of these genes and that the ability of the individual, distinct G/C-rich elements to confer regulated expression on a promoter deletion mutant of the pst-cath/CP2 gene is correlated with the relative affinity for GBF. G/C-rich elements carrying point mutations that prevent in vitro binding of GBF to two of the G/C-rich elements fail to activate expression in vivo. An analysis of major points of contact between the GBF protein and two distinctly different binding sites suggests that binding of GBF to these sequence elements involves a considerable degree of flexibility in DNA-protein interactions. These results suggest that the regulated expression of a class of aggregate-stage cAMP-inducible genes involves the interaction of GBF or homologous factors with dissimilar G/C-rich sequence elements and that induction of GBF activity or that of homologous factors by cAMP may thus be a limiting step in the induction of this temporally coordinate set of genes during Dictyostelium development.
Solar Energy: An Infinite Source of Clean Energy (1973)

Abundance, cleanliness and widespread distri bution are great incentives for the application of solar energy to man's energy requirements. Recent and impend ing fuel shortages, cost increases of energy and environ mental degradation have provided strong incentives for the development of solar energy for wide practical use. However, its low intensity and high variability impose severe econo mic problems in converting it to useful forms. Conversion of solar radiation to thermal, electrical and mechanical energy has been well demonstrated in numerous experi mental systems. Of these methods, those of greatest current interest are the production of heat for the heating and cooling of buildings and the direct, or indirect, conversion to elec tricity. In favorable locations, the costs of solar heating and cooling equipment under development appear to be nearly competitive with fuels; hence, this application is ex pected to be widespread within a very few years. Electric power from solar energy is not now competitive with conventional supply and is, therefore, a longer term possibility.