gebhart/patrepeval huggingface dataset:
Interleukin-2 Gene Transfer into Murine Neuroblastoma Decreases Tumorigenicity and Enhances Systemic Immunity Causing Regression of Preestablished Retroperitoneal Tumors (1994)

Murine neuroblastoma, neuro-2a, was transduced with the retroviral vector LIL-2SN in order to examine the influence of localized interleukin (IL)-2 production on the immune response against a low major histocompatibility complex (MHC) class I, class II-negative, and intercellular adhesion molecule (ICAM)-1-negative tumor. Two neomycin-resistant (neo R) clones, N-2a/IL-2/L (2.5 +/- 0.4 U/ml/10(6) cells/24 h) and N-2a/IL-2/H (44.6 +/- 8.8 U/ml), were studied as representative low and high IL-2 producers, respectively. Using a recently developed retroperitoneal (r.p.) model for implantation of neuroblastoma in its natural site, we demonstrated that production of IL-2 by neuro-2a reduces its tumorigenicity in a dose-dependent fashion. T-cell, but not natural killer (NK) cell, depletion significantly increased tumor induced mortality in syngeneic A/J mice. Mice genetically devoid of T-cells (C.B-17 scid/scid) also experienced a significant increase in mortality rates. This indicates that the antitumor effect of locally secreted IL-2 is mediated primarily through activation of T-cells. Immunization of mice with irradiated N-2a/IL-2/H cells resulted in protection when challenged at a later date with unmodified neuro-2a cells. Depletion of CD8+, but not CD4+, T-cells prior to vaccination abrogated the protective effect, indicating that the priming phase of the immune response is CD8+ T-cell dependent. Mice with established r.p. tumors were vaccinated with N-2a/IL-2/H, which significantly prolonged their survival compared to unimmunized controls and to mice immunized with non-IL-2-producing neuro-2a cells. Because of the similarities of this model with the human tumor, our studies indicate that IL-2-transduced neuroblastoma cells may be effective in generating systemic immunity leading to eradication of minimal residual disease.
A 67.1-ps FOM, 0.5-V-Hybrid Digital LDO With Asynchronous Feedforward Control Via Slope Detection and Synchronous PI With State-Based Hysteresis Clock Switching (2018)

We present a fully integrated digital low-drop-out regulator (LDO) with a 100-pF output capacitor (COUT) in 65 nm, based on hybrid-synchronous-asynchronous control. The goal is to minimize both response and settling time for abrupt load changes, which in turn enables the COUT scaling under a voltage droop constraint. The architecture is based on the synchronous proportional-integral feedback control in tandem with the asynchronous feedforward control. The asynchronous control loop employs load-event-based triggering, which compensates the output voltage immediately after a voltage droop, shortening response time. Then, the synchronous loop operates on either fast or slow clock selected automatically by a hysteresis control and quickly brings the output to the steady state, achieving short settling time. The proposed hysteresis control achieves superior stability and scales the lower bound of the slow-clock frequency by two orders over the existing scheme. The LDO prototype improves the responseand settling-time related metrics over the prior synchronous and asynchronous LDOs.
Effect of Freezing, Storage and Thawing Conditions on Quality of Frozen Cooked Rice. (2001)

マイクロ波加熱解凍を前提とした冷凍おにぎりの品質向上に向けて,米飯塊の凍結条件と貯蔵条件が米飯の諸特性に及ぼす影響を明確にすることを検討した.その結果,次のことがわかった.(1) 凍結温度を-13.0～-31.0℃,貯蔵温度を-31.0℃,貯蔵期間を7日間程度にした場合,未凍結の場合に比べて米飯塊の白濁および黄変の抑制,破断特性の維持が図れて良好であることが明らかになった.(2) マイクロ波加熱解凍における米飯塊の温度挙動は,加熱時間と最終温度との到達時間の間に一定の傾向が認められなかった.これは,米飯塊の粒子形状が試料により不均一な集合体であることに起因すると推察した.(3) マイクロ波加熱解凍後の水分含量は,米飯塊の中心部が低く,表層部が高くなる傾向が認められた.これは,急激な温度上昇により中心部の水蒸気圧が高くなって水分子が外側に拡散されるのに対して,表層部は包装により水分が保持されるためと考えられた.(4) 自然解凍した米飯塊のデンプンの糊化度は,凍結温度,貯蔵温度および貯蔵期間に対して一定の傾向は認められないことから,冷凍米飯の品質劣化の主因ではないことが示唆された.低温恒温恒湿機や色彩色差計などの使用に御便宜を図って頂きました岩手県工業技術センターおよび岩手大学地域共同研究センターに感謝致します.なお,成果の一部を日本食品科学工学会第47回大会(2000年3月,東京)において口頭発表した.
Antimitotic Rhizoxin Derivatives from a Cultured Bacterial Endosymbiont of the Rice Pathogenic Fungus <i>Rhizopus</i> <i>m</i> <i>icrosporus</i> (2006)

The potent antimitotic polyketide macrolide rhizoxin, the causal agent of rice seedling blight, is not produced by the fungus Rhizopus microsporus, as has been believed for over two decades, but by endosymbiotic bacteria that reside within the fungal mycelium. Here we report the successful isolation and large-scale fermentation of the bacterial endosymbiont ("Burkholderia rhizoxina") in pure culture, which resulted in a significantly elevated (10x higher) production of antimitotics. In addition to several known rhizoxin derivatives, numerous novel natural and semisynthetic variants were isolated, and their structures were fully elucidated. Cell-based assays as well as tubulin binding experiments revealed that methylated seco-rhizoxin derivatives are 1000-10000 times more active than rhizoxin and thus rank among the most potent antiproliferative agents known to date. Furthermore, more stable didesepoxy rhizoxin analogues were obtained by efficiently inhibiting a putative P-450 monooxygenase involved in macrolide tailoring.
Porosity mapping in petroleum reservoirs using seismic data: A geostatistical approach (1984)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1984Porosity mapping in petroleum reservoirs using seismic data: A geostatistical approachAuthors: P. DoyenA. JonrnelA. NurP. DoyenStanford Univ., A. JonrnelStanford Univ., and A. NurStanford Univ.https://doi.org/10.1190/1.1894019 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1894019FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1984ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1984 Pages: 856 publication data© 1984 Copyright © 1984 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 24 Mar 2005 CITATION INFORMATION P. Doyen, A. Jonrnel, and A. Nur, (1984), "Porosity mapping in petroleum reservoirs using seismic data: A geostatistical approach," SEG Technical Program Expanded Abstracts : 328-330. https://doi.org/10.1190/1.1894019 Plain-Language Summary PDF DownloadLoading ...
An evaluation of different page allocation strategies on high-speed SSDs (2012)

Exploiting internal parallelism over hundreds NAND flash memory is becoming a key design issue in high-speed Solid State Disks (SSDs). In this work, we simulated a cycle-accurate SSD platform with twenty four page allo-cation strategies, geared toward exploiting both system-level parallelism and flash-level parallelism with a variety of design parameters. Our extensive experimental anal-ysis reveals that 1) the previously-proposed channel-and-way striping based page allocation scheme is not the best from a performance perspective, 2) As opposed to the cur-rent perception that system and flash-level concurrency mechanisms are largely orthogonal, flash-level parallelism are interfered by the system-level concurrency mechanism employed, and 3) With most of the current parallel data access methods, internal resources are significantly under-utilized. Finally, we present several optimization points to achieve maximum internal parallelism. 1
A Complete Fabrication Route for Atomic-Scale, Donor-Based Devices in Single-Crystal Germanium (2011)

Despite the rapidly growing interest in Ge for ultrascaled classical transistors and innovative quantum devices, the field of Ge nanoelectronics is still in its infancy. One major hurdle has been electron confinement since fast dopant diffusion occurs when traditional Si CMOS fabrication processes are applied to Ge. We demonstrate a complete fabrication route for atomic-scale, donor-based devices in single-crystal Ge using a combination of scanning tunneling microscope lithography and high-quality crystal growth. The cornerstone of this fabrication process is an innovative lithographic procedure based on direct laser patterning of the semiconductor surface, allowing the gap between atomic-scale STM-patterned structures and the outside world to be bridged. Using this fabrication process, we show electron confinement in a 5 nm wide phosphorus-doped nanowire in single-crystal Ge. At cryogenic temperatures, Ohmic behavior is observed and a low planar resistivity of 8.3 kΩ/□ is measured.
Actinomycin-D plus 5-(3,3-dimethyl- 1-triazeno)- imidazole-4-carboxamine (DTIC) with or without intravenous corynebacterium parvum in metastatic malignant melanoma (1982)

Chemotherapy and chemoimmunotherapy of Stage IV B malignant melanoma were compared in 88 patients. Chemotherapy consisted of DTIC 250 mg/M2 of the body surface area daily x five days and actinomycin-D 2 mg/M2 on day 1 repeated every 3--4 weeks. Chemoimmunotherapy consisted of the same regimen plus C. parvum 2 mg/M2 I.V. daily for 14 days before every third cycle of chemotherapy, plus 2 mg/M2 I.V. daily on days 7 and 14 of each 21--28 day chemotherapy cycle. There was 32 evaluable chemotherapy and 33 evaluable chemoimmunotherapy patients and the groups were well balanced for clinical and pathologic as well as prognostic variables. The complete and partial remission rates, remission and survival durations, and hematologic and gastrointestinal toxicities were different in the two randomized groups being 6 and 3%, 9 and 9%, 7.6 and 12 months, 8.8 and 6.0 months, 20 and 16%, and 62 and 70%, respectively for these parameters. This difference was not statistically significant. Therefore, it can be concluded that the results of chemotherapy with actinomycin-D plus DTIC were not substantially different from those reported using DTIC alone, and that we cannot recommend the addition of actinomycin-D to DTIC for palliative management in these patients. Furthermore, C. parvum immunotherapy did not add to chemotherapy in terms of remission rate, remission duration, or survival for patients with Stage IV B malignant melanoma.
The Hydrolysis of Ferric Complexes. Magnetic and Spectrophotometric Studies of Aqueous Solutions of Ferric Salts (1973)

Abstract Ferric chloro, ferric aquo, and ferric sulfato complexes in acidic solutions have been hydrolyzed at temperatures below 70°C to form polynuclear complexes of iron(III). Magnetic and spectrophotometric studies have then been carried out in order to clarify the nature of the polynuclear complexes. From these studies, their empirical formulas are presumed to be Fe2(OH)2Cl2O, Fe2(OH)3(NO3)3, Fe2(OH)3(SO4)3⁄2, and Fe3(OH)2(SO4)7⁄2. The iron ions in these polynuclear complexes are in a high spin state, as are those in the ferric complexes, iron oxides, and oxyhydrates. It is proposed that, in all these polynuclear complexes except Fe3(OH)2(SO4)7⁄2, edge-shared octahedral dimer units are antiferromagnetically linked with one another by hydroxy or oxo bridging. When the hydrolysis temperature is raised, these polynuclear complexes are further hydrolyzed to form precipitates. The complexes of Fe2(OH)2Cl2O, Fe2(OH)3(SO4)3⁄2, and Fe3(OH)2(SO4)7⁄2 give β-FeOOH, α-FeOOH, and RFe3(OH)6(SO4)2 (R=Na, K or NH4) respectively, whereas the complex of Fe2(OH)3(NO3)3 gives α-FeOOH or α-Fe2O3, depending on the temperature.
Gastric GATA‐6 DNA‐binding protein: proteolysis induced by cAMP (1997)

The rat gastric GATA DNA-binding protein, GATA-6 (GATA-GT1), was stably expressed in CHO-K1 cells. The GATA-6 protein was localized in the nucleus but not in the cytoplasm. Interestingly, when cells were treated with dibutyryl cAMP, the GATA-6 protein was specifically degraded. Such a phenomenon was not observed in the presence of 5'-AMP or dibutyryl cGMP. The cellular level of the GATA-6 protein was restored upon removal of dibutyryl cAMP. Degradation was also induced by cholera toxin, which increased the cellular cAMP concentration, and was inhibited by a protein kinase A inhibitor. However, activators of protein kinase C did not have any effect. The degradation was inhibited by proteasome inhibitors (PSI (benzyloxycarbonyl-Ile-Glu(O-t-Bu)-Ala-leucinal) and MG115 (benzyloxycarbonyl-Leu-Leu-norvalinal)) but not by those of lysosomes and serine proteases. These results suggest that a kinase-mediated protein phosphorylation is the cellular signal for degradation of the GATA-6 protein. This finding constitutes a novel aspect of regulation by GATA DNA-binding proteins, which are essential for developmental processes and tissue-specific transcription.
An Unprecedented [C2+C1+C1] Coupling of an Alkynyl, an Allenylidene, and a CO Unit: The Formation of a Highly Unsaturated Cyclobutenone Derivative in the Coordination Sphere of Rhodium(I) (2000)

Mono- and dinuclear organometallic rhodium(I) complexes such as 1 are obtained in excellent yields by the reaction of trans-[RhF{=C=C=C(Ph)R}(PiPr3)2] with triphenylstannanes PhC≡CSnPh3 and Ph3SnC≡CC≡CSnPh3. Compound 1 undergoes an unprecedented [C2+C1+C1] coupling reaction with CO to produce the highly unsaturated cyclobutenone derivative 2. R=Ph, tBu; L=iPr3.
<title>Virometer - Real-Time Virus Detection And Identification In Biological Fluids</title> (1977)

An optical microscopic instrument is described that will allow visual observation and photoelectric detection measurement and classification of moderate concentrations of viruses in biological fluids in a few minutes. The instrument combines fluorescence correlation spectroscopy and ATR fluorescence with special electronics and a correlator fast Fourier transform data system to measure the size of viral particles while disregarding background objects found in typical biological fluids. Further data processing allows calculation of the nucleic acid mass of individual particles and their total concentration. A novel chemical procedure is employed to differentiate various types of viral nucleic acid. The combination of these measurements is then used to classify a virion without requiring the use of a specific antibody for it. Calibration of the system against test objects and compounds, as well as measurements on several virus types will be shown.
Summary of LaRC 2-inch Erectable Joint Hardware Heritage Test Data (2016)

As the National Space Transportation System (STS, also known as the Space Shuttle) went into service during the early 1980's, NASA envisioned many missions of exploration and discovery that could take advantage of the STS capabilities. These missions included: large orbiting space stations, large space science telescopes and large spacecraft for manned missions to the Moon and Mars. The missions required structures that were significantly larger than the payload volume available on the STS. NASA Langley Research Center (LaRC) conducted studies to design and develop the technology needed to assemble the large space structures in orbit. LaRC focused on technology for erectable truss structures, in particular, the joint that connects the truss struts at the truss nodes. When the NASA research in large erectable space structures ended in the early 1990's, a significant amount of structural testing had been performed on the LaRC 2-inch erectable joint that was never published. An extensive set of historical information and data has been reviewed and the joint structural testing results from this historical data are compiled and summarized in this report.
A new patient‐derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α‐dystroglycan (2019)

Dystroglycan, an extracellular matrix receptor, has essential functions in various tissues. Loss of α-dystroglycan-laminin interaction due to defective glycosylation of α-dystroglycan underlies a group of congenital muscular dystrophies often associated with brain malformations, referred to as dystroglycanopathies. The lack of isogenic human dystroglycanopathy cell models has limited our ability to test potential drugs in a human- and neural-specific context. Here, we generated induced pluripotent stem cells (iPSCs) from a severe dystroglycanopathy patient with homozygous FKRP (fukutin-related protein gene) mutation. We showed that CRISPR/Cas9-mediated gene correction of FKRP restored glycosylation of α-dystroglycan in iPSC-derived cortical neurons, whereas targeted gene mutation of FKRP in wild-type cells disrupted this glycosylation. In parallel, we screened 31,954 small molecule compounds using a mouse myoblast line for increased glycosylation of α-dystroglycan. Using human FKRP-iPSC-derived neural cells for hit validation, we demonstrated that compound 4-(4-bromophenyl)-6-ethylsulfanyl-2-oxo-3,4-dihydro-1H-pyridine-5-carbonitrile (4BPPNit) significantly augmented glycosylation of α-dystroglycan, in part through upregulation of LARGE1 glycosyltransferase gene expression. Together, isogenic human iPSC-derived cells represent a valuable platform for facilitating dystroglycanopathy drug discovery and therapeutic development.
Extended Concept of Crosstalk Elimination in Multiconductor Transmission Lines (2006)

This paper presents an extension of the concept of total elimination of crosstalk between signals propagating in multiconductor transmission lines. The assumption is that the crosstalk should be eliminated by proper feeding and matching at the line ends, in the presence of physical coupling between conductors all along the lines. Unlike previous publications on the subject, this paper investigates in detail the influence of configurations of input/output setups including non-ideal sources and bidirectional transmission. The concept is verified using SPICE circuit simulator. It is expected to be useful in various applications including fast interconnects.
Aromatic polyureas for second-order nonlinear optics (1993)

Nonlinear optical materials possessing large second-order optical nonlinearities at short wavelengths are highly desirable for laser frequency conversion to fabricate high-power laser sources. 1-4 Organic polymers are important materials because they offer the advantages of thin film processability, ease of structural modification and fabrication. Therefore organic polymers having nonlinear optical (NLO) chromophores either in the main chain or as pendant groups have attracted a great deal of attention. An efficiency/transparency trade-off is the most important factor for practical applications in the field of nonlinear optics. Organic NLO polymers having persistent large second-order optical nonlinearity coupled with desired optical transparency at the fundamental as well as at the second-harmonic wavelengths can be utilized in many applications. Bearing in mind the efficiency/transparency trade-off, we have designed and synthesized a wide variety of polyureas exhibiting large second-order optical nonlinearity and good optical transparency. 5,6 This paper describes the second-order optical nonlinearities of novel aromatic polyureas having pendant NLO chromophores. The relationships between molecular structures and optical as well as nonlinear optical properties of polyureas are discussed.
Active single pole double throw switches for D-Band applications (2016)

This paper presents active single pole double throw (SPDT) switches, based on a novel compact transistor unit cell, working in the D-Band (110-170GHz) frequency range. Two switches for the transmit- and receive side were designed and manufactured using a GaAs mHEMT process. The unit cell consists of the integration of a common-gate stage for loss compensation and a shunt-stage to achieve high isolation. On-wafer measurement results of the processed monolithic microwave integrated circuits (MMICs) SPDT switches show a maximum gain of 3.2dB and 3.3dB with 3dB bandwidths of 47GHz and 38.7GHz, respectively. Within the 3dB bandwidth the isolation of both switches is higher than 21.5dB.
Late expression of M and N antigens on glycophorin A during erythroid differentiation (1985)

The M/N blood groups are carried by the major human red cell sialoglycoprotein, glycophorin A. O-glyosidic carbohydrate is needed for the activity, but the M/N specificity is due to amino acid replacements in the NH2-terminal portion of the molecule. We have used monoclonal antibodies specific for M and N blood groups to study their expression during normal erythropoiesis. Here we report that the M/N blood group activities are very weakly or not at all expressed before the polychromatic normoblast stage. Using polyclonal anti-glycophorin A antiserum, it was shown that glycophorin A molecules are already abundantly present on the earliest morphologically recognizable erythroid precursor, the proerythroblast. These findings can be explained by our previous observation that the O-glycosylation of glycophorin A gradually increases during erythroid maturation.
Mass Transport in Chalcogenide Electrolyte Films — Materials and Applications (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Quasi-two-body reactions at 50-200 GeV (1970)

We propose a wire spark chamber experiment to study peripheral reactions which lead to a final state containing one or more resonances. An example is {pi}{sup +} {yields} {rho}{sup o}{Delta}{sup ++}. The experiment is intended to measure a variety of such processes simultaneously, for pions, kaons, and protons incident on protons. The range of four-momentum transfers will be from essentially zero to about 1 (GeV/c){sup 2}. The major goals of the experiment may be summarized as follows: 1. To study the s and t dependence of the cross sections for peripheral processes in order to check various dynamical models. 2. To search for new meson and baryon resonances and in favorable cases to determine their quantum numbers. 3. To study {pi}-{pi} and K-{pi} scattering in those reactions which produce baryon resonances predominantly by pion exchange.
Subthalamic nucleus deep brain stimulation for Parkinson’s disease: evidence for effectiveness and limitations from 12 years' experience (2014)

The functional state of Parkinson's disease patients with motor disabilities refractory to best medical treatment improved significantly after subthalamic nucleus deep brain stimulation. A dedicated multidisciplinary team building, refined protocol for patient selection and assessment, improvement of targeting methods, meticulous surgical technique, and experience in programming are the key factors contributing to the improved outcome.
Algorithms for Program Verification. (1982)

Abstract : In the previous reporting period, July 1979 to June 1980, work was performed on (1) foundations for specifying automatic program verifiers (Pr1,Pr3), (2) decision methods for a large fragment of the basic logic of programs (Pr5), (3) implementation of a decision method for propositional dynamic logic, and (4) continued maintenance of MITVI (LP), a program verifier incorporating some of these ideas. In the current (and final) reporting period, the research emphasis shifted from the verification of sequential programs to that of dataflow programs. This week has led to new insights into the correspondence between functions and processes (Pr4,Pr7). It has also stimulated work on a new approach to user environments (Pr6). And it has raised, though not answered, problems concerning automated verification of dataflow programs. (Author)