gebhart/patrepeval huggingface dataset:
Synthesis of tritium labelled verrucarol and verrucarin a (1989)

Abstract Two tritium labelled trichothecenes, verrucarol (2) and verrucarin A (5) were synthesized with high specific activity. Oxidation of verrucarol (1) to the 15‐dehydroverrucarol (3) followed by sodium borotritide reduction yielded [15‐ 3 H]‐verrucarol (2). Reduction of 16‐mesyloxyverrucarin A (7) in a special buffer‐organic solvent system with a phase transfer catalyst, produced [16‐ 3 H]‐verrucarin A (5). Final purification of the radioactive products was achieved by preparative thin layer chromatography. Their structures were assigned based on the analytical data of the corresponding nonradiolabelled compounds obtained from the nonradioactive preparations.
Characterization of individual electron traps in amorphous Si by telegraph noise spectroscopy (1986)

We have used telegraph noise spectroscopy to study the properties of individual localized electron traps of a particular type in thin layers (t&lt;∼6 nm) of rf sputtered amorphous Si and amorphous Si:H. The results indicate that these traps have bistable ionic configurations: The trapping kinetics are dominated by transitions between two different ionic configurations with an associated change in trapped charge. Above ∼20 K, configurational transitions are by thermally activated hopping; below 20 K, transitions appear to be induced by zero-point oscillations.
Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production (2016)

Vitamin D insufficiency is a worldwide epidemic affecting billions of individuals, including pregnant women and children. Despite its high incidence, the impact of active vitamin D3 (1,25(OH)D3) on embryonic development beyond osteo-regulation remains largely undefined. Here, we demonstrate that 1,25(OH)D3 availability modulates zebrafish hematopoietic stem and progenitor cell (HSPC) production. Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1<sup>+</sup>cMyb<sup>+</sup> HSPC numbers. Selective modulation in vivo and in vitro in zebrafish indicated that vitamin D3 acts directly on HSPCs, independent of calcium regulation, to increase proliferation. Notably, ex vivo treatment of human HSPCs with 1,25(OH)D3 also enhanced hematopoietic colony numbers, illustrating conservation across species. Finally, gene expression and epistasis analysis indicated that CXCL8(IL-8) was a functional target of vitamin D3-mediated HSPC regulation. Together, these findings highlight the relevance of developmental 1,25(OH)D3 availability for definitive hematopoiesis and suggest potential therapeutic utility in HSPC expansion.
Lazy Signature: A non-registered Digital Signature Using Biometrics (2013)

The conventional digital signature is implemented and operated as function of registered stamp or signature for digital documents. In real world, however, it is rare to use registered stamps or signatures, and non-registered ones are more used often. If it is possible to apply non-registered stamp/signature system to digital world, it is expected that digital signature will become more useful and effective. To achieve this, it is vital to ensure that the signing key is not registered, but still repudiation is prevented. So, we propose to combine digital signature and biometric signature to connect signing key and signer with each other. Thus, a non-registered digital signature is realized in this paper. Keyword Digital signature,Biometrics,Non-registered signature
Visual Databases need Data Models for Multimedia Data. (1989)

S.433-461
Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementation of actinorhodin synthase mutants (1994)

Complementation of defined actinorhodin beta-ketoacyl synthase (KS) mutants by various other KS genes suggested that the ORF1-encoded KS may be relatively generalized in function, whereas the ORF2-encoded KS component may provide specificity in polyketide chain construction. Evidence for differential temporal-spatial expression of the actinorhodin and spore pigment KSs in Streptomyces coelicolor was obtained.
Purines Bearing Phenanthroline or Bipyridine Ligands and Their Ru<sup>II</sup> Complexes in Position 8 as Model Compounds for Electrochemical DNA Labeling – Synthesis, Crystal Structure, Electrochemistry, Quantum Chemical Calculations, Cytostatic and Antiviral Activity (2007)

Abstract A series of ethynyl‐ or (4‐boronophenyl)bipyridines and‐phenanthrolines were prepared as versatile building blocks for attachment of bidentate N‐ligands to other molecules via cross‐coupling reactions. Their complexation with Ru(bpy) 2 Cl 2 gave the corresponding Ru II complexes. 9‐Benzyladenine derivatives bearing the bipyridine or phenanthroline complexes in position 8, attached via a conjugate acetylene or phenylene linker were prepared by cross‐coupling reactions of the ethynyl‐ or 4‐boronophenylbipyridines and ‐phenanthrolines with 9‐benzyl‐8‐bromoadenine. Their complexation with Ru(bpy) 2 Cl 2 afforded the corresponding Ru complexes as model compounds for electrochemical DNA labeling. The same compounds were also prepared directly by cross‐coupling of 9‐benzyl‐8‐bromoadenine with Ru complexes of the alkynes and boronic acids. Both approaches are compared in terms of potential applications for labeling of nucleic acids. The crystal structures of two Ru complexes were determined by X‐ray diffraction. The electrochemistry of the model purines bearing the phenanthroline or bipyridine ligands and the Ru complexes was studied by means of cyclic or square‐wave voltammetry with carbon paste and mercury electrodes. The experimental redox potentials of the title compounds were compared with quantum chemical calculations. A very good agreement between experiment and theory was obtained, with a standard deviation of 0.13 V. It was shown that theoretical calculations can be of a limited predictive power for new Ru II complexes, though it was difficult to reproduce differences smaller than 0.05 V. Several compounds of this series exhibited a considerable cytostatic effect and activity against the hepatitis C virus (HCV). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Pannexin 1 – a novel regulator of hypoxic pulmonary vasoconstriction (2021)

Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia by which pulmonary blood flow is redirected from poorly ventilated areas to better aerated lung regions. Sustained HPV plays a critical role in the development of pulmonary hypertension (PH) but the exact signaling pathways underlying HPV remain incompletely defined. Recently, ATP release via Pannexin 1 (Panx1) and subsequent purinergic signaling have been linked to transient receptor potential vanlloid 4 (TRPV4) channel mediated Ca 2+ signaling in systemic vasoconstriction. Here, we probed for a similar role of Panx1 in HPV and the development of PH. To test the role of Panx1, we measured HPV as increase in pulmonary artery pressure (PAP) in response to hypoxia in lungs of endothelial cell (Cdh5‐CreERT2/Panx1 fl/fl ) and smooth muscle cell specific (SMMHC‐CreERT2/Panx1 fl/fl ) Panx1‐KO mice. Isolated perfused lungs (IPL) of C57Bl6/J and Panx1‐deficient mice were ventilated with normoxic (20% O 2 ; 5% CO 2 , 75% N 2 ) or hypoxic gas (1% O 2 ; 5% CO 2 , 94% N 2 ) and PAP was recorded via a pulmonary artery catheter. To elucidate the role of Panx1 in the development of PH, C57Bl6/J as well as Panx1‐KO mice were kept under hypoxic conditions (10% O 2 ) for 5 weeks followed by measurement of right ventricular systolic pressure, echocardiography and histology. Panx1 protein was expressed in human pulmonary artery endothelial cells as well as in human pulmonary artery smooth muscle cells (hPASMCs). Genetic deletion of Panx1 in smooth muscle cells, yet not in endothelial cells reduced the HPV response in isolated mouse lungs. In lungs of C57Bl6/J mice, Panx1‐inhibition by the non‐specific Panx1 inhibitors spironolactone or probenecid and the Panx1 specific inhibitory peptide ( 10 Panx1) effectively attenuated HPV. Yet, genetic deletion of Panx1 in either endothelial or smooth muscle cells did not prevent the development of PH in mice. Interestingly, ATP release in response to hypoxia was not detectable in PASMC, and ATP degradation as well as inhibition of purinergic receptors failed to affect HPV. Rather, TRPV4 antagonism and Panx1 inhibition inhibited the hypoxia‐induced increase of intracellular Ca 2+ concentration ([Ca 2+ ] i ) in PASMC in an additive manner, suggesting that Panx1 regulates [Ca 2+ ] i independently of the ATP‐P2Y‐TRPV4 signaling axis. In line with this notion, Panx1 overexpression increased the [Ca 2+ ] i response to hypoxia in HeLa cells. Here we identify Panx1 as novel regulator of HPV. The role of Panx1 in HPV was, however, not attributable to ATP release and downstream purinergic receptor signaling or TRPV4 activation, but may involve a direct role of Panx1 as Ca 2+ channel. In contrast to its role in HPV, Panx1 does not seem to contribute to chronic hypoxic PH.
Ares Launch Vehicles Development Awakens Historic Test Stands at NASA's Marshall Space Flight Center (2008)

This paper chronicles the rebirth of two national rocket testing assets located at NASA's Marshall Space Flight Center: the Dynamic Test Stand (also known as the Ground Vibration Test Stand) and the Static Test Stand (also known as the Main Propulsion Test Stand). It will touch on the historical significance of these special facilities, while introducing the requirements driving modifications for testing a new generation space transportation system, which is set to come on line after the Space Shuttle is retired in 2010. In many ways, America's journey to explore the Moon begins at the Marshall Center, which is developing the Ares I crew launch vehicle and the Ares V cargo launch vehicle, along with managing the Lunar Precursor Robotic Program and leading the Lunar Lander descent stage work, among other Constellation Program assignments. An important component of this work is housed in Marshall's Engineering Directorate, which manages more than 40 facilities capable of a full spectrum of rocket and space transportation technology testing - from small components to full-up engine systems. The engineers and technicians who operate these test facilities have more than a thousand years of combined experience in this highly specialized field. Marshall has one of the few government test groups in the United States with responsibility for the overall performance of a test program from conception to completion. The Test Laboratory has facilities dating back to the early 1960s, when the test stands needed for the Apollo Program and other scientific endeavors were commissioned and built along the Marshall Center's southern boundary, with logistics access by air, railroad, and barge or boat on the Tennessee River. NASA and its industry partners are designing and developing a new human-rated system based on the requirements for safe, reliable, and cost-effective transportation solutions. Given below are summaries of the Dynamic Test Stand and the Static Test Stand capabilities, along with an introduction to the new missions that these sleeping giants will be fulfilling as NASA readies the Ares I for service in the 2015 timeframe, and plans the development work for fielding the Ares V late next decade (fig. 1). Validating modern computer design models and techniques requires the sorts of data that can only be generated by these one-of-a-kind facilities.
Angle estimation in MIMO radar using a new sparse representation approach (2019)

Existing direction of arrival (DOA) estimation methods in multiple-input multiple-out (MIMO) radar systems will encounter the performance degradation in the cases of few snapshots, low signal-to-noise ratio (SNR), closely spaced targets, or strongly correlated sources. To improve it, this paper develops a new sparse representation-based DOA estimation method. The main contributions are as follows: i) we construct a new real-valued double weighted l2,1-norm minimisation model; ii) we derive an improved reduced-dimension technique to enhance estimation accuracy; and iii) we design optimal and sparse weights carefully to improve the corresponding estimation accuracy. Finally, the effectiveness and theoretical analysis of the presented approach are verified by extensive numerical simulations, which proves that the new algorithm performs well at low SNR and with a small number of snapshots as well as at the coherent source case.
Resveratrol, a Phytochemical Inducer of Multiple Cell Death Pathways: Apoptosis, Autophagy and Mitotic Catastrophe (2011)

Cancers are the largest cause of mortality and morbidity in industrialized countries. In the field of the medicinal chemistry of natural products, numerous studies have reported interesting properties of trans-resveratrol as a chemopreventing agent against cancers, inflammation, and viral infection. Tumor growth inhibition has been linked to the ability of resveratrol to arrest cell cycle progression and to trigger cell death. This review focuses on the pathways that mediate resveratrol-induced cell death. Resveratrol impacts on the mitochondrial functions (respiratory chain, oncoproteins, gene expression, etc), in which p53 protein can be involved and its acetylated or phosphorylated forms. This polyphenol also affects death receptor distribution in ceramide-enriched membrane platforms which serve to trap and cluster receptor molecules, and facilitates the formation of a death-inducing signaling complex in the cell. To induce apoptosis, resveratrol also activates the ceramide / sphingomyelin pathway, which promotes ceramide generation and the downstream activation of kinase cascades. Resveratrol can activate alternative pathways to cell death such as those leading to autophagy, senescence or mitotic catastrophe. Furthermore, numerous attempts have been made using resveratrol analogs to improve the molecule's ability to block cell proliferation and induce cell death. Moreover, structural modification of natural phenolics is expected to produce analogs that may be useful tools to study the structure-activity relationships. Lastly, in various cancer types, resveratrol behaves as a chemosensitizer that lowers the threshold of cell death induction by classical anticancer agents and counteracts tumor cell chemoresistance.
A model-based approach for visual guided grasping with uncalibrated system components (2005)

In this paper, a complete framework for the task of grasping a naturally textured object is being presented. The lack of calibration in the components of the eye-in-hand system is overcome by an image trajectory based visual servoing scheme (ITBVS). Using an object model reconstructed off-line, consecutive rough pose estimation and refinement of the estimate by scale optimized 3D model to object registration solves the feature correspondence problem in the absence of artificial landmarks. Experimental results using a zoom camera and a 7-DOF serial manipulator prove the effectiveness of the approach.
Current Status of Hybrid PET/MRI in Oncologic Imaging (2015)

Radiologists should understand the technical considerations that have made PET/MRI feasible within clinical workflows, the role of PET tracers for imaging various molecular targets in oncology, and advantages of hybrid PET/MRI compared with PET/CT. To facilitate this understanding, we discuss clinical examples (including gliomas, breast cancer, bone metastases, prostate cancer, bladder cancer, gynecologic malignancy, and lymphoma) as well as future directions, challenges, and areas for continued technical optimization for PET/MRI.
Perceptual Cepstral filters for speech and music processing (2013)

Source-filter modeling of speech or musical tones requires a filter model for the spectral envelope of the signal. To reduce the number of modeling parameters, one idea is the use of psychoacoustic knowledge to encode only the relevant information in a perceptual sense. Starting from an accurate estimation of the original spectral envelope, with imperceptible details, in this work, we propose to use its Mel-Frequency Cepstral Coefficient (MFCC) representation to catch the perceptually relevant information. Then, a new inverse process is presented to derive a smoother, but perceptually equivalent spectral envelope. For instance, this new method can be applied in speech coding, and thanks to the good properties of the MFCC representation, perceptual interpolations of sounds is made easier.
The Rebound Characteristics of Seats (1999)

<div class="section abstract"><div class="htmlview paragraph">This paper examines how a human torso rebounds from seats in low to moderate speed collisions. A torso model and a seat model are combined and numerical integration is used to predict the response characteristics.</div></div>
System States Analysis and Flow Graph Diagrams in Reliability (1966)

A method is described which permits rapid evaluation of reliability functions and some probabilistic parameters related to the operation of systems. The method is based on the concept of system states and on the observation that, in terms of such states, the probabilistic behavior of systems is well described by the Markov process in infinitesimal dt, whenever subsystems behave independently of each other and randomly in time. Out of many methods useful to determine the probability that a system is in state Sj at time t, i. e., to solve the set of system state differential equations, the algorithm of the signal flow diagram has been emphasized here. Actually, such an algorithm gives us a Laplace transform of the reliability function rapidly and easily, from which one can evaluate some probabilistic parameters related to the reliability of systems (as the well-known mean time between failures) without passing through time-domain. Several applications have been examined, some of which can be resolved with intuitive methods, while some others cannot.
Health Care System in the 21st Century and the Role of the Anesthesiologist. Part I. The Crisis in the Japanese System with Lack of a Comprehensive Reform Plan. (2000)

20世紀後半に起こった人口の急速な高齢化に伴う医療費の高騰で,健康保険財政が急速に悪化し,国民皆保険制度が今,破綻の危機に瀕している.国が進めてきたさまざまな医療費抑制政策もこの傾向を大きく変えることはできず,健康保険制度の抜本改革の必要性が叫ばれ,2000年の抜本改革を目指して医療保険福祉審議会,中央社会保険医療協議会等の場で審議が続けられている.しかし,関連組織団体間の合意がなかなか得られず,このまま進めばタイムリミットを超えて制度崩壊が進む可能性も出てきている.しかし,制度の仕組み,問題点が複雑なこと,複数の改革案が出ていること,外に出てくる情報も各団体,組織に都合のよい断片的なものが多いこと等から,医療従事者でさえ全体像がつかみにくい.一方,医療の先進国であるはずのアメリカも同様の深刻な問題が生じており,急速に増加する老人医療費に対する公的保険の抜本改革案に加えて,多くの民間医療保険がさまざまな問題点を指摘されるなかで,次々と改良を加えて急成長するなど壮大な社会実験が進行中である.この実験は世界の注目を集めており,先のみえない日本の医療制度の方向を探るうえで大いに参考になる可能性がある.医療制度の変貌とともに,われわれ麻酔科医を取り巻く環境も急速に厳しくなっていくのは確実である.しかし,この変化のなかで,日本麻酔学会及び個々の麻酔科医の役割も新しい可能性を秘めながら変化していくことが予想され,このような動きに注目し,理解を深める必要がある.
Physician Knowledge and Perspectives Regarding Influenza and Influenza Vaccination (2005)

To achieve the goal of universal influenza vaccination coverage for the 2004-05 season for healthy children 6-23 months of age, physicians will need a greater understanding of the severity of influenza illness in this age group coupled with an increased knowledge of indications for vaccine administration.
Simulation des Kapazitätsabgleiches (1974)

Das beschriebene Kapazitätsabgleichverfahren ist — wie eingangs dargestellt wurde — ein Baustein eines umfassenden integrierten Terminplanungssystems. Es muß daher so ausgelegt werden, daß ein einfaches Einfügen in das Gesamtsystem möglich ist, d. h. die Anschlüsse an die “benachbarten” Bausteine müssen klar definiert werden.
Side-To-Side Comparisons of Bone Mineral Density in Upper and Lower Limbs of Collegiate Athletes (2002)

This cross-sectional study investigated the effects of participation in various sports on side-to-side (contralateral) differences in bone mineral density (BMD) of the upper and lower limbs. The BMD of the arms and legs was measured using dual energy X-ray absorptiometry. The subjects were 184 collegiate athletes, both men and women, who participated in NCAA Division I-A baseball, basketball, football, golf, soccer, tennis, cross-country, indoor/outdoor track, and volleyball. Results revealed greater BMD of the right arms compared with the left arms for all teams, with the most pronounced differences observed in men's and women's tennis and men's baseball. Differences in the lower limbs were less common. No significant differences in lower limb BMD were found in the women. In men, differences in lower limb BMD were found in the football and tennis teams, with the nondomi-nant leg having greater bone mass. Recognition of contra-lateral differences in bone density may be of particular interest to strength and conditioning professionals as they consider the need to include bilateral and unilateral training programs in an effort to maximize performance and minimize stress-related injuries.
The copolymerization of styrene and maleic anhydride. Free radical reactivities under heterogeneous conditions (1953)

C. H. Bamford and W. G. Barb, Discuss. Faraday Soc., 1953, 14, 208 DOI: 10.1039/DF9531400208
Bromine as a partial oxidant. Oxidation state and charge transport in brominated nickel and palladium bis(diphenylglyoximates). A comparison with the iodinated materials and resonance Raman structure-spectra correlations for polybromides (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBromine as a partial oxidant. Oxidation state and charge transport in brominated nickel and palladium bis(diphenylglyoximates). A comparison with the iodinated materials and resonance Raman structure-spectra correlations for polybromidesDavida W. Kalina, Joseph W. Lyding, Mark T. Ratajack, Carl R. Kannewurf, and Tobin J. MarksCite this: J. Am. Chem. Soc. 1980, 102, 27, 7854–7862Publication Date (Print):December 1, 1980Publication History Published online1 May 2002Published inissue 1 December 1980https://pubs.acs.org/doi/10.1021/ja00547a005https://doi.org/10.1021/ja00547a005research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SonicSeat: A Seat Position Tracker based on Ultrasonic Sound Measurements for Rowing Technique Analysis (2012)

A significant share of rowers does not have access to professional supervision by coaches. However, proper technique is a key component for both success in competitions and to prevent injuries or long-term induced postural deformity. In cooperation with national rowing coaches we developed a sensor
Bit-flip injection strategies for FSMs modeled in VHDL behavioral level (2010)

This paper presents two strategies to inject bit-flips in FSMs modeled in VHDL behavioral level. The dependability validation to SEUs or MEUs into the FSM flip flops is carried out by means of minor modifications on the VHDL description. The simulation results show that the proposed strategies have a low area overhead, allow synchronous and asynchronous fault injection and are very suitable to carry out the dependability validation step on FSMs.