gebhart/patrepeval huggingface dataset:
Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis (2016)

Multiciliogenesis is essential for the function of different epithelia, and its failure results in brain defects, respiratory diseases, and infertility. In this issue of Genes & Development, Nemajerova and colleagues (pp. 1300-1312) reveal the p53 family member and p73 isoform TAp73 as a transcription factor dictating the differentiation of multiciliated cells. Their findings provide the long-awaited unifying explanation for the diverse phenotypes of the p73 knockout mice.
Safety and Efficacy of Tinefcon (Sphaeranthus indicus) Cream in Treatment of Plaque Psoriasis - A Phase II B, Double Blind, Randomized, and Placebo Controlled Study (2016)

Background: Sphaeranthus indicus is acknowledged for its immunomodulatory and anti-inflammatory activities, and possess anti-TNF (tumour necrosis factors) activity. Objective: To evaluate the safety and efficacy of Tinefcon (Sphaeranthus indicus) cream in treatment of plaque psoriasis. Method: This was a phase-IIB, double-blind, randomized, and placebo controlled clinical trial. Total 86 patients diagnosed with stable plaque psoriasis were randomized (2:1 ratio) into two groups and studied for a period of 90 days. Medications were randomly assigned into 58 subjects from Tinefcon cream group and 28 subjects from placebo group. The efficacy parameters studied were mean percent change in local psoriasis severity index (LPSI) of a target lesion, dermatology quality of life index (DQLI), visual analogue scale (VAS), physicians' global assessment (PHGA), and patient's global assessment (PTGA). The cosmetic acceptance and safety profile of Tinefcon cream was also evaluated. Results: Tinefcon cream reduced the target lesion severity by 69.94% as compared to 51.11% reduction (t = 3.0, p = 0.004) in placebo. 70.7% patients achieved reduction ≥ 50% as compared to 42.9% in placebo group (F = 0.013, p = 0.013) and 41.4% patients achieved reduction ≥ 75% as compared to 21.4% in placebo group (F = 0.06, p = 0.06) in target lesion severity. The mean percentage reduction of itching and pain assessed by DQLI in Tinefcon cream was 62.89% as compared to 43.45% in placebo and VAS produced significant mean percent reduction of target lesion by 68.35% in Tinefcon-group as compared to 53.50% in placebo group. In addition, no adverse or serious adverse events occurred during the study. Conclusions: Tinefcon cream was safe and effective in the treatment of stable plaque psoriasis.
The maxillary anterior single tooth implant aesthetic-health compromise. (1995)

With implant function established as a predictable treatment modality, the emphasis during the last decade has shifted to aesthetic of the restoration, particularly in the maxillary anterior area, sometimes to the extent of compromise of hygiene in the cervical region. The author reviews the aesthetics-hygiene compromise, in the context of long-term maintenance and survival, and suggests a compromise in cervical aesthetics in "unaesthetic" areas and even in the maxillary anterior if the cervical region is not exposed with broad smile. The presentation is a reminder that aesthetics is not the only criteria for an implant crown. The aesthetic-health compromise must be considered and understood prior to the treatment so that the most appropriate treatment plan can be developed.
Behavioral synthesis techniques for intellectual property protection (1999)

Article Free Access Share on Behavioral synthesis techniques for intellectual property protection Authors: Inki Hong Synopsys, Inc. Mountain View, CA and Computer Science Department, University of California, Los Angeles, CA Synopsys, Inc. Mountain View, CA and Computer Science Department, University of California, Los Angeles, CAView Profile , Miodrag Potkonjak Computer Science Department, University of California, Los Angeles, CA Computer Science Department, University of California, Los Angeles, CAView Profile Authors Info & Claims DAC '99: Proceedings of the 36th annual ACM/IEEE Design Automation ConferenceJune 1999 Pages 849–854https://doi.org/10.1145/309847.310085Published:01 June 1999Publication History 13citation4,259DownloadsMetricsTotal Citations13Total Downloads4,259Last 12 Months5Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
ChemInform Abstract: EINFLUSS DER KONFIGURATION AUF DIE REGIOSELEKTIVITAET DER BROMIERUNG VON CIS‐ UND TRANS‐4‐TERT.‐BUTYL‐ACETYLCYCLOHEXAN (1975)

Abstract Die Titelreaktion ergibt hauptsächlich das 1‐Bromacetylderivat, dessen Konfiguration von der der Ausgangsverbindung abhängt, sowie das cis‐ und trans‐Isomere des 1‐Brom‐1‐acetylderivats.
The role of the cytoskeleton in the viscoelastic properties of human articular chondrocytes (2004)

Abstract Biomechanical factors are believed to play an important role in regulating the metabolic activity of chondrocytes in articular cartilage. Previous studies suggest that cytoskeletal proteins such as actin, vimentin, and tubulin influence cellular mechanical properties, and may therefore influence the mechanical interactions between the chondrocyte and the surrounding tissue matrix. In this study, we investigated the role of specific cytoskeletal components on the mechanical properties of individual chondrocytes isolated from normal or osteoarthritic hip articular cartilage. Chondrocytes were exposed to a range of concentrations of chemical agents that disrupt the primary cytoskeletal elements (cytochalasin D for F‐actin microfilaments, acrylamide for vimentin intermediate filaments, and colchicine for microtubules). Chondrocyte mechanical properties were determined using the micropipette aspiration technique coupled with a viscoelastic solid model of the cell. Chondrocyte stiffness (elastic modulus) was significantly increased with osteoarthritis. With increasing cytochalasin D treatment, chondrocyte stiffness decreased by up to 90% and apparent viscosity decreased by up to 80%. The effect of cytochalasin D was greater on normal chondrocytes than those isolated from osteoarthritic cartilage. Treatment with acrylamide also decreased the moduli and viscosity, but only at the highest concentration tested. No consistent changes in cell mechanical properties were observed with colchicine treatment. These findings suggest that microfilaments and possibly intermediate filaments provide the viscoelastic properties of the chondrocyte, and changes in the structure and properties of these cytoskeletal elements may reflect changes in the chondrocyte with osteoarthritis. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.
Content-based tools for editing audio stories (2013)

Audio stories are an engaging form of communication that combine speech and music into compelling narratives. Existing audio editing tools force story producers to manipulate speech and music tracks via tedious, low-level waveform editing. In contrast, we present a set of tools that analyze the audio content of the speech and music and thereby allow producers to work at much higher level. Our tools address several challenges in creating audio stories, including (1) navigating and editing speech, (2) selecting appropriate music for the score, and (3) editing the music to complement the speech. Key features include a transcript-based speech editing tool that automatically propagates edits in the transcript text to the corresponding speech track; a music browser that supports searching based on emotion, tempo, key, or timbral similarity to other songs; and music retargeting tools that make it easy to combine sections of music with the speech. We have used our tools to create audio stories from a variety of raw speech sources, including scripted narratives, interviews and political speeches. Informal feedback from first-time users suggests that our tools are easy to learn and greatly facilitate the process of editing raw footage into a final story.
INHIBITION OF NEOINTIMAL FORMATION BY BERAPROST SODIUM (BPS) IN THE PORCINE CORONARY ARTERY AFTER BALLOON INJURY (2004)

Yamasaki, K; Tomita, N; Kunugiza, Y; Koike, H; Aoki, M; Ogihara, T; Morishita, R Author Information
<i>Escherichia coli</i> and herpes-simplex-virus ribonucleotide reductase R2 subunit. Compared reactivities of the redox centres (1993)

Protein R2, the small subunit of ribonucleotide reductase, contains a diferric centre and a tyrosyl radical absolutely required for enzyme activity. The reduction of the tyrosyl radical and the mobilization of the iron centre result in the inhibition of the enzyme and thus of DNA synthesis. The chemical reactivity of the iron-radical centre of Escherichia coli and herpes simplex virus has been studied by u.v.-visible and e.p.r. spectroscopies. The tyrosyl radical is efficiently scavenged by hydroxamic acids and phenols during reactions controlled by steric hindrance and hydrophobic interactions. The reaction with o-disubstituted phenols yields the corresponding diphenoquinones. The reactivity of the bacterial radical greatly contrasts with that of the viral radical, and the iron centre in herpes-simplex-virus R2 is much more labile than that in E. coli R2, as shown from the facile mobilization of iron by chelators such as catechol. These results suggest that the active sites of the two enzymes are significantly different and might be useful for designing new antiviral agents.
Extension of scaling laws for model experiments (1976)

Of the four dimensionless ratios required to characterize acoustic data [I.C. Romer, Jr., J. Acoust. Soc. Am. 59&gt;, 1227–1229 (1976)] two depend exclusively on the physical properties of the acoustic fluid. A third ratio is kept invariant in the usual scaled models, whereby dimensions L and frequencies f are modeled respectively, as L/s and sf. A fourth ratio is the “sonic Reynolds Number”, ρL2f/μ, which controls boundary layer phenomena. It remains invariant if linear dimensions are scaled as L/s1/2. Reflection and absorption by Rayleigh solids, and other boundary phenomena can be modeled by scaling boundary statistics, e.g., boundary roughness, and interstitial spaces in porous layers (fibrous blankets and sandy ocean bottoms) as L/s1/2, while scaling macroscopic dimensions, e.g., layer thickness, as L/s. [Work supported by USN Office of Naval Research.]
The ecological differentiation of asexual lineages of cotton aphids: alate behaviour, sensory physiology, and differential host associations (2009)

The cotton aphid (Aphis gossypii Glover) is a cosmopolitan pest species consisting of various host plant-associated lineages that appear to have different patterns of insecticide resistance, electrophoretic banding, and reproductive output across alternative host species. Debate continues as to whether these differences represent intraspecific variation or indicate a complex of cryptic or sibling species. We studied the host plant-related ecology of two asexual lineages of A. gossypii associated with the families Malvaceae and Cucurbitaceae, respectively, in particular the host plant finding and acceptance processes of the alate forms. The two lineages proved to be differentiated across host plants in terms of: (1) their landing and settling behaviour, nymphal production rate, and subsequent colony establishment (i.e. nymphal survival and development) and (2) their sensory abilities in relation to host plant-derived odours. Furthermore, genetic structuring according to host plant type was detected using the gene for elongation factor 1-α. The magnitude of the genetic differentiation across lineages was low, perhaps indicating a relatively recent divergence. The results demonstrate: (1) the presence of (at least) two cryptic species within the current definition of A. gossypii, as anticipated in previous studies, and (2) the practicalities of using a multidisciplinary approach to understanding the 'limits' of asexual species. If sexuals can be generated from each of these lineages, this conclusion will be open to further testing.
On the Role and Significance of Fas (Apo-1/CD95) Ligand (FasL) Expression in Immune Privileged Tissues and Cancer Cells Using Multiple Myeloma as a Model* (1998)

Our knowledge in immunology has been dramatically increased by several excellent investigations elucidating the role of the Fas (Apo-1/CD95) receptor/ligand (FasL) system in complex immunological processes such as the acquisition of self tolerance in T cells, progression of autoimmunity, clonal deletion of activated T cells, B-cell regulation and the establishment of "immune privileged" sites such as testis or retina. In addition to these regulatory immunological activities, Fas/FasL interaction was also shown to participate in active defense mechanisms of the host against infected or transformed cells thereby inducing apoptosis in target cells. However, the same mechanism seems also to be part of an escape strategy utilized by tumor cells in various neoplastic malignancies of both hematopoetic as also non-hematopoetic origin. We ourselves were able to demonstrate that neoplastic plasma cell lines, as well as native malignant myeloma cells constitutively express FasL mRNA and protein. The FasL molecule is functionally active and able to induce programmed cell death in Fas sensitive target T cells in vitro. These target T cells were protected from programmed cell death by preincubation of T cells with a Fas-blocking monoclonal antibody (mAb) or of myeloma cells with a FasL-neutralizing mAb. respectively. Furthermore, overexpression of the caspase inhibitor, cowpoxvirus protein CrmA, also protected target T cells from being killed by myeloma cells, identifying Fas/FasL mediated signaling as the effector pathway utilized by malignant plasma cells. Our observations strongly suggest the engagement of Fas/FasL interaction in the escape strategy of this malignancy. The molecular basis of this evasive mechanism differs in essential respects from those described in melanoma, lung cancer, hepatocellular carcinoma, or astrocytoma, since downregulation of Fas or instrinsic insensitivity towards Fas-mediated signaling were not prerequisites for the occurrence of this phenomenon in Fas-sensitive multiple myeloma cell lines. However, myeloma cell lines resisted cocultivation with FasL-expressing target T cells in vitro. The aim of this review is to discuss the role of Fas/FasL interaction in the establishment of malignant disease, in the light of our findings on myeloma cells and also by drawing upon similar observations of other investigators on different kinds of tumor cells and cell lines and further to consider its possible relevance in formulating novel approaches to cancer therapy.
Root Archutecture Affects Nitrate Leaching from Bentgrass Turf (1998)

Understanding the determinants of nitrate leaching should improve nitrogen uptake efficiency and reduce ground water contamination. This column lysimeter study examined the effect of root architecture on NO 3 leaching from two genotypes of creeping bentgrass ( Agrostis palustris Huds.) differing in rooting characteristics. Ammonium nitrate was applied (50 kg N ha −1 ) and the columns were irrigated with 1, 2 or 3 cm day −1 (Exp. 1) or irrigation was delayed 1, 3 or 5 d (Exp. 2). In Exp. 1, leachate NO 3 concentrations and total N leached from the shallow‐rooted (SR) genotype were approximately twice those from the deep‐rooted (DR) genotype. An average of 38 and 18% of the applied N leached from the SR and DR genotypes, respectively. Cumulative leaching losses increased with irrigation depth. In Exp. 2, NO 3 leaching was reduced 90% or more by increasing the time period for immobilization from 1 to 5 d. Recovery of applied 15 N in the tissue averaged 87% after 2 mo. Absorption of NO 3 and NH 4 was measured in nutrient solution culture. The SR genotype had significantly higher uptake rates than DR for both forms of N, expressed on a root weight basis. Collectively these data indicate that a deep‐rooted turfgrass absorbs N more efficiently than a shallowrooted turf, reducing the concentration and total amount of NO 3 leached. The effect is apparently not due to differences in N uptake, but rather to rooting patterns. Environmental conditions and management practices that affect rooting depth and density may thus affect N nutrition and NO 3 leaching.
Influence of Alloying Elements on the Solubility of Hydrogen in Vanadium (1974)

Solubility of hydrogen in vanadium and its binary alloys containing titanium, chromium, iron and cobalt, respectively was measured in the temperature range between 600 and 1200°C under one atmosphere pressure of hydrogen gas. The influence of alloying elements on the solubility, and the correlation between hydrogen solubility and electronic structure of alloys were discussed.The following results were obtained:(1) The solubility decreased with increase in amount of each alloying element, with the exception of titanium.(2) The lattice strain induced by alloying did not affect the solubility.(3) Relative partial molar entropy and enthalpy increased linearly with increase in electron/atom ratio from 4.9 to 5.4.(4) Variation in entropy was correlated to that in the electronic specific heat coefficient of alloy.(5) Variation in enthalpy was explained by that in density of state at the Fermi surface in the alloys.
Combustion Chamber Fluid Dynamics and Hypergolic Gel Propellant Chemistry Simulations for Selectable Thrust Rocket Engines (2007)

This paper describes the application of high performance computing to accelerate the development of hypergolic propulsion systems for tactical missiles. Computational fluid dynamics is employed to model the chemically reacting flow within a system's combustion chamber, and computational chemistry is employed to characterize propellant physical and reactive properties. Accomplishments from the past year are presented and discussed.
The Reaction of Isoprene with t-Butyl Hypochlorite in Hydroxylic Solvents (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction of Isoprene with t-Butyl Hypochlorite in Hydroxylic SolventsWilliam Oroshnik and Robert A. MalloryCite this: J. Am. Chem. Soc. 1950, 72, 10, 4608–4613Publication Date (Print):October 1, 1950Publication History Published online1 May 2002Published inissue 1 October 1950https://pubs.acs.org/doi/10.1021/ja01166a076https://doi.org/10.1021/ja01166a076research-articleACS PublicationsRequest reuse permissionsArticle Views408Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fries Rearrangement in Calixarene Esters: A New Entry for the Synthesis of <i>p</i>-Substituted Calixarenes (1988)

Abstract The Fries rearrangement was found to be a convenient method to synthesize p-acylcalixarenes from O-acylcalixarenes, the yields being relatively good (29–34%) as a synthetic method for p-substituted calixarenes.
Synthesis and Electrochemical Properties of Li[Ni[sub 1/3]Co[sub 1/3]Mn[sub (1/3−x)]Mg[sub x]]O[sub 2−y]F[sub y] via Coprecipitation (2004)

The mixed transition metal layered compound, was synthesized via coprecipitation followed by a high-temperature heat-treatment. X-Ray diffraction patterns revealed that this material has a typical layered structure with space group. Spherical morphologies have been observed by scanning electron microscopy. Mg and F substitutions were effective for the improvement of physical properties such as crystallinity, morphology, and tap-density. These improved physical characteristics enhanced the capacity, retention and thermal stability, even though the electrodes were cycled between 2.8 and 4.6 V. © 2004 The Electrochemical Society. All rights reserved.
Kidd Blood Group and Urea Transport Function of Human Erythrocytes Are Carried by the Same Protein (1995)

The gene encoding the urea transporter of human erythrocytes (HUT11 clone) has been cloned recently (Olives, B., Neau, P., Bailly, P., Hediger, M. A., Rousselet, G., Cartron, J. P., and Ripoche, P. (1994) J. Biol. Chem. 269, 31649-31652). Now, this gene has been assigned to chromosome 18q12-q21 by in situ hybridization, as also found for the Kidd (Jk) blood group locus. In coupled transcription-translation assays, the HUT11 cDNA directed the synthesis of a 36-kDa protein which was immunoprecipitated by a human anti-Jk3 antibody produced by immunized Jk(a-b-) donors whose red cells lack Kidd antigens. The anti-Jk3 antibody also immunoprecipitated a protein material of 46-60 kDa from all red cell membranes, except those from Jk(a-b-) cells. After N-glycanase digestion the 46-60-kDa component was reduced to 36 kDa. A rabbit antibody raised against the predicted NH2-terminal amino-acids of the HUT11 protein reacted on immunoblots with a 46-60-kDa component present in all human erythrocytes except those from Jk(a-b-) individuals. Jk(a-b-) red cells lack the Kidd/urea transport protein and have a selective defect of the urea transport capacity, but a normal water permeability and aquaporin-associated Colton blood group antigens. These findings indicate that the erythrocyte urea transporter is encoded by the Kidd locus and may have implications for the biology of urea transporters and their tissue-specific regulation.
Automatic bootstrapping of OpenFlow networks (2013)

OpenFlow decouples the control plane functionality from switches, and embeds it into one or more servers called controllers. One of the challenges of OpenFlow is to deploy a network where control and data traffic are transmitted on the same channel (in-band mode). Implementing such an in-band mode is complex, since switches have to search and establish a path to the controller (bootstrapping) through the other switches in the network. In this paper, we propose a method that facilitates this automatic bootstrapping of switches. In this method, the controller establishes its own control network through the neighbor switches that are connected to it by the OpenFlow protocol. We measure suitability of the proposed method by performing bootstrapping experiments in different types of topologies: linear, ring, star and mesh topologies. The experimental results show that the proposed method allows bootstrapping in a minimal time, which makes it suitable even for a large network.