gebhart/patrepeval huggingface dataset:
Monoclonal antibody to a proximal nephrogenic renal antigen: immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas. (1989)

An IgG1 murine monoclonal antibody (PN-15) to an epitope preserved in formalin-fixed, paraffin-embedded tissue sections of renal cell carcinomas was developed following immunization of mice with the microsomal fraction of human renal cortical tissue homogenates. An immunohistochemical screening procedure was utilized against fixed, embedded tissue sections of renal cell carcinomas. This antibody identified a Mr 200,000 determinant on immuno-Western blot analysis, and the recognized epitope was shown to reside in the carbohydrate domain of a Mr 200,000 glycoprotein (gp200). Analysis of its tissue distribution was performed by indirect immunoperoxidase staining of fixed, embedded tissue sections of the following: 36 different types of normal tissues; 45 primary and 38 metastatic renal cell carcinomas; and 124 cases of 39 different types of neoplasms. In the normal kidney, gp200 was localized along the brush border of the proximal tubule and the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Shared tissue localization was also noted in breast lobules and ducts, parathyroid gland, and epididymis. The gp200 was expressed by 93% of primary and 84% of metastatic renal cell carcinomas, primarily on the cell surface membrane. Shared antigenic expression was noted in relatively few other tumors including: mammary carcinomas; teratocarcinomas; and parathyroid adenomas. The PN-15 monoclonal antibody holds promise as a useful reagent in retrospective investigations of fixed, embedded cases of renal cell carcinomas. The antibody may also be of practical utility in diagnostic immunohistochemistry by helping to retrospectively define the primary site of metastatic clear cell tumors, especially when fresh frozen tissue from such tumors is not available.
Induction of Lung Fibroblast Apoptosis by Soluble Fibronectin Peptides (2000)

Despite the importance of fibroproliferative lung disorders, no safe and effective therapies exist for reducing the size of the fibroblast population in existing fibrotic lesions. Recent work suggests that therapies that promote fibroblast apoptosis during the repair phase following lung injury may facilitate lung repair by eliminating excess fibrotic tissue. We report here our finding that three soluble fibronectin peptides (RGD, CS-1, and FN-C/H-V) induce apoptosis in lung fibroblasts. Fibroblast susceptibility to these peptides was dose and time dependent, with a maximal effect observed at 96 h (87 +/- 16% [mean +/- SEM] apoptosis). The peptides were able to induce fibroblast apoptosis in fibrin gels, an in vitro model of early fibroproliferative lesions. Fibroblasts were difficult to kill. All three peptides were required for maximal apoptosis of anchored cells. Apoptosis occurred by disruption of adhesion (anoikis). Treatment of fibroblasts with peptides caused proteolysis of pp125FAK, a tyrosine kinase involved in integrin-mediated signaling related to cell survival. These data show that soluble fibronectin peptides trigger nontransformed fibroblast apoptosis in routine culture and in fibrin gels by a mechanism that includes disruption of an integrin-mediated survival signaling pathway. The use of small fibronectin peptides to promote fibroblast apoptosis warrants further study as possible antifibrotic therapy.
Effect of Powder Size and Shape on the SLS Processability and Mechanical Properties of a TPU Elastomer (2016)

This work investigates the influence of powder size/shape on selective laser sintering (SLS) of a thermoplastic polyurethane (TPU) elastomer. It examines a TPU powder which had been cryogenically milled in two different sizes; coarse powder (D50∼200μm) with rough surfaces in comparison with a fine powder (D50∼63μm) with extremely fine flow additives. It is found that the coarse powder coalesces at lower temperatures and excessively smokes during the SLS processing. In comparison, the fine powder with flow additives is better processable at significantly higher powder bed temperatures, allowing a lower optimum laser energy input which minimizes smoking and degradation of the polymer. In terms of mechanical properties, good coalescence of both powders lead to parts with acceptable shear-punch strengths compared to injection molded parts. However, porosity and degradation from the optimum SLS parameters of the coarse powder drastically reduce the tensile properties to about one-third of the parts made from the fine powders as well as those made by injection molding (IM).
Hurricane-Induced Loads on Offshore Wind Turbines with Considerations for Nacelle Yaw and Blade Pitch Control (2014)

During extreme tropical storm systems such as hurricanes, offshore wind turbines are required to have adequate structural integrity in parked condition and with blades pitched to feather. Such turbine states are preferred in order to mitigate loads on the turbine blades; simultaneously, yaw control is required so as to track the changing wind direction in this configuration. During a hurricane, however, it is possible that a turbine's yaw control system might operate abnormally due to damage of the control and protection system or due to loss of the electric grid and/or insufficient backup power. In earlier studies, the authors have shown that feathered blades can lead to higher tower bending moments in the side-to-side (lateral) direction rather than in the fore-aft (longitudinal) direction. In the present study, we carry out an in-depth investigation of the effect of several alternative parked configurations on an offshore turbine's response using numerical simulations with coupled wind-wave fields during a hurricane. We use these output wind-wave fields obtained from the University of Miami Coupled Model (UMCM), a fully coupled atmosphere-wave-ocean model that is used to simulate the storm and associated environmental fields and is able to represent relevant physical processes at the air-sea interface. In this study, we evaluate: (1) the effect of different nacelle yaw angles relative to the wind direction (i.e., different amounts of yaw error or misalignment); (2) the effect of different blade pitch angles; (3) the effect of different turbine parking strategies—e.g., parked and at a standstill or in an idling state; and (4) load maxima at different blade azimuthal configurations while the turbine is in a standstill state. The effects of the different turbine parked configurations on turbine response are evaluated under only wind loads first; later, wave loads are included to reflect possible joint metocean conditions likely to be encountered during a hurricane.
Reducing lower-extremity amputations due to diabetes. Application of the staged diabetes management approach in a primary care setting. (1998)

The customization and systematic implementation of practice guidelines by local primary care providers was associated with improved diabetic foot care outcomes. SDM has relevance to primary care organizations seeking to improve outcomes for patients with diabetes.
Low Jitter Adpll Based Clock Generator For High Speed Soc Applications (2008)

An efficient architecture for low jitter All Digital Phase Locked Loop (ADPLL) suitable for high speed SoC applications is presented in this paper. The ADPLL is designed using standard cells and described by Hardware Description Language (HDL). The ADPLL implemented in a 90 nm CMOS process can operate from 10 to 200 MHz and achieve worst case frequency acquisition in 14 reference clock cycles. The simulation result shows that PLL has cycle to cycle jitter of 164 ps and period jitter of 100 ps at 100MHz. Since the digitally controlled oscillator (DCO) can achieve both high resolution and wide frequency range, it can meet the demands of system-level integration. The proposed ADPLL can easily be ported to different processes in a short time. Thus, it can reduce the design time and design complexity of the ADPLL, making it very suitable for System-on-Chip (SoC) applications.
Magnetoresistive phenomena in nanoscale magnetic systems (2008)

Nanomagnetic materials are playing an increasingly important role in modern technologies. A particular area of interest involves the interplay between magnetism and electric transport, i.e. magnetoresistive properties. Future generations of field sensors and memory elements will have to be on a length scale of a few nanometers or smaller. Magnetoresistive properties of such nanoscale objects exhibit novel features due to reduced dimensionality, complex surfaces and interfaces, and quantum effects. In this dissertation theoretical aspects of three such nanoscale magnetoresistive phenomena are discussed. Very narrow magnetic domain walls can strongly scatter electrons leading to an increased resistance. Specifically, this dissertation will cover the newly predicted effect of magnetic moment softening in magnetic nanocontacts or nanowires. Atomically thin domain walls in Ni exhibit a reduction, or softening, of the local magnetic moments due to the noncollinearity of the magnetization. This effect leads to a strong enhancement of the resistance of a domain wall. Magnetic tunnel junctions (MTJs) consist of two ferromagnetic electrodes separated by a thin layer of insulating material through which current can be carried by electron tunneling. The resistance of an MTJ depends on the relative orientation of the magnetization of the two ferromagnetic layers, an effect known as tunneling magnetoresistance (TMR). A first-principles analysis of CoFeB:MgO:CoFeB MTJs will be presented. Calculations reveal that it is energetically favorable for interstitial boron atoms to reside at the interface between the electrode and MgO tunneling barrier, which can be detrimental to the TMR effect. Anisotropic magnetoresistance (AMR) is the change in resistance of a ferromagnetic system as the orientation of the magnetization is altered. In this dissertation, the focus will be on AMR in the tunneling regime. Specifically we will present new theoretical results on tunneling AMR (TAMR) in two systems: (i) planar MTJs with CoFe electrodes and (ii) fully broken magnetic break junctions. In both cases electronic resonances in the electrodes lead to complex angular and bias dependence of the TAMR. The theoretical studies demonstrate the basic physical phenomenon behind recent experimental data.
Microbiological study of used cosmetic products: highlighting possible impact on consumer health (2019)

The nature and high level of contamination in used cosmetic products indicate that greater user awareness and education are required. Manufacturers should ensure that product expiry dates are prominently displayed and consumers can identify the symbols used on product packaging.
Dynamic light scattering by aqueous solutions of rodlike fd-virus particles (1991)

Dynamic light scattering (DLS) measurements on aqueous solutions of rodlike fd-virus particles (length=880 nm, diameter=9 nm) below and above the overlap concentration c*=1 particle/length3 are reported. In samples with screened Coulomb interaction the short-time behavior of the time correlation functions does not show a significant concentration dependence, in contrast to samples at very low ionic strength (strong Coulomb interaction), where the short-time behavior is dominated by the static structure factor S(q). In this case S(q) derived by DLS methods, using an equation that has been proved for interacting spherical particles and weakly interacting rods, is in excellent agreement with S(q) determined by static light scattering (SLS) up to a particle concentration of about 5c*. Above significant deviations are found. At very low ionic strength the existence of a distinct very long tail in the time correlation function as previously reported can be confirmed, but the new experiments suggest that this is due to dust particles and aggregates and not to the interaction between the fd particles.
The microcirculation and its measurement in sepsis (2016)

The microcirculation describes the smallest elements of the cardiovascular conducting system and is pivotal in the maintenance of homeostasis. Microcirculatory dysfunction is present early in the pathophysiology of sepsis, with the extent of microcirculatory derangement relating to disease severity and prognosis in ICU patients. However, at present microcirculatory function is not routinely monitored at the bedside. This article describes the pathophysiology of microcirculatory derangements in sepsis, methods of its measurement and evidence to support their clinical use.
'I Dare You to Try and Heal Me': Alliance Formation for Cases of Complex Resistance (2011)

The notion of 'resistance' in therapy has a controversial history - when interpersonal interactions do not go well, the tendency is to blame the problem on the personality of the person seeking professional care. In this article, Dan Short explores the notion of 'complex resistance' in which the client seeks a powerful intervention and, at the same time, is ambivalent about treatment. Such clients may announce they are ready to comply with the treatment they desperately need, but then respond with resistance to any procedure that requires compliance. Clinical situations characterised by this form of resistance are viewed as a display of complex interpersonal needs that if unmet will result in prolonged frustration for both client and therapist. In preference to traditional responses of blaming the client or referring on, the task of the skillful therapist is to adjust his or her style of relating in order to meet the needs of a particular client. A case study is used to illustrate how to respond to complex resistance through an interplay of dominant and submissive postures that is sensitive to the unique needs of each client.
Moving Object Detection Based on Background Subtraction of Block Updates (2013)

This article presents a block-updating moving object detection method-background subtraction. This method weights the former two frames of start frame, models initial background, then subtracts current frames and background frame, divides difference image into multiple sub blocks, computes sum and does threshold comparison of total pixels of each block, gets binary image through threshold segmentation, and isolates background area and foreground area. Background area is used to model and update background model. According to the test, this method is insensitive to outside environment and can detect moving object correctly.
Ammonia as a Hydrogen Source for Fuel Cells: A Review (2012)

The concept of a hydrogen economy was revived in the 1990s as interest in fuel cell technology surged. There was an explosion of research into fuel cells since then mainly because of its status as a hydrogen technology, and as such both concepts shared a symbiotic relationship. However there are a number of problems with the direct use of hydrogen in fuel cells. Firstly hydrogen does not exist naturally. Secondly it is not easy to store or transport because of its low volumetric energy density and its small molecular size.
Test node-based WCL algorithm for wireless sensor networks (2016)

From a system perspective, cost effectiveness and high-precision location information are important in wireless sensor networks (WSNs). Since a weighted centroid localization (WCL) algorithm can reduce hardware installation cost and guarantee localization accuracy, this algorithm is considered as one of the promising localization algorithms for WSNs. In this paper, we propose a test node-based WCL algorithm for improving the localization accuracy and making the localization system cost effective. The simulation results show that the proposed test node-based WCL algorithm provides higher precision location information than the conventional WCL algorithm with a reduced number of real anchor nodes.
Female Pattern Hair Loss: a clinical and pathophysiological review (2015)

Female Pattern Hair Loss or female androgenetic alopecia is the main cause of hair loss in adult women and has a major impact on patients' quality of life. It evolves from the progressive miniaturization of follicles that lead to a subsequent decrease of the hair density, leading to a non-scarring diffuse alopecia, with characteristic clinical, dermoscopic and histological patterns. In spite of the high frequency of the disease and the relevance of its psychological impact, its pathogenesis is not yet fully understood, being influenced by genetic, hormonal and environmental factors. In addition, response to treatment is variable. In this article, authors discuss the main clinical, epidemiological and pathophysiological aspects of female pattern hair loss.
Oxidative Stress, Cell Activation and Viral Infection (1994)

Since the appearance of photosynthesis on our planet, all living organisms have been facing a new abundant, extremely reactive element, oxygen. This element is used for the synthesis of highly energet
Notes on Church-State Affairs (1994)

Journal Article Notes on Church-State Affairs Get access Rosalie Beck, Rosalie Beck Search for other works by this author on: Oxford Academic Google Scholar David W. Hendon David W. Hendon Search for other works by this author on: Oxford Academic Google Scholar Journal of Church and State, Volume 36, Issue 2, Spring 1994, Pages 417–450, https://doi.org/10.1093/jcs/36.2.417 Published: 01 March 1994
DNA gyrase improves DNA transformation of<i>E.coli</i>cells with large recombinant plasmids (1995)

DNA gyrase improves DNA transformation of E.coli cells with large recombinant plasmids Get access Yao Zhixing, Yao Zhixing Institut de Pharmacologie Moleculaire et Cellulaire660 Route des Lucioles, 06560 Valbonne, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Louis Nahon Jean-Louis Nahon * Institut de Pharmacologie Moleculaire et Cellulaire660 Route des Lucioles, 06560 Valbonne, France * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 23, Issue 16, 25 August 1995, Pages 3353–3354, https://doi.org/10.1093/nar/23.16.3353 Published: 25 August 1995 Article history Received: 01 June 1995 Accepted: 19 July 1995 Published: 25 August 1995
Exogenous enzymes for pigs and poultry (1998)

Many feed ingredients in use in monogastric diets contain significant quantities of antinutritional factors (ANF) which limit both their feed value and their use. Almost all enzymes currently being used address such factors to varying degrees, allowing for more economic utilization of raw materials. However, animal response to xylanase, beta-glucanase and even phytase utilization reported in the literature tends to vary. Factors such as enzyme source, ingredient variety and environment under which the ingredient was grown, stored and processed into animal feed, age of animal, interaction with other dietary ingredients, and health status are shown to affect significantly the response obtained. As a result, the mode of action of xylanases and beta-glucanases is still debated due to too much emphasis being placed on interpretation of individual trial results without regard to the interactive factors or the literature dataset as a whole. Better understanding of such factors will improve data interpretation. While results with phytase are not subject to such extreme variation, they are nevertheless inconsistent in the degree to which inorganic phosphorus can be replaced by this enzyme. Greater understanding of the ANF and factors which interact to govern the response to added exogenous enzymes will undoubtedly improve the economic return and confidence in their use. Improved knowledge of ANF structure will result in development of enzymes directed towards far more specific targets, which enhances the likelihood of success and should reduce the overall enzyme usage.
Universal Design in Housing (1998)

Universal design in housing is a growing and beneficial concept. It is subtle in its differences from barrier-free, accessible, and industry standard housing. Accessibility standards and codes have not mandated universal design and do not apply to most housing. Universal design exceeds their minimum specifications for accessible design and results in homes that are usable by and marketable to almost everyone. Universal homes avoid use of special assistive technology devices and, instead, incorporate consumer products and design features that are easily usable and commonly available.
Cutaneous leishmaniasis mimicking inflammatory and neoplastic processes: a clinical, histopathological and molecular study of 57 cases (2011)

The manifestations of cutaneous leishmaniasis are broad and may mimic other inflammatory and neoplastic diseases. Pathologists and dermatologists should be aware of such pitfalls and can utilize PCR to confirm the diagnosis of leishmaniasis.
Microsoft Virtualization with Hyper-V (2009)

Implement a Hyper-V virtualization solution

Microsoft Virtualization with Hyper-V shows you how to deploy Microsoft's next-generation hypervisor-based server virtualization technology in a corporate environment. You'll get step-by-step guidelines for getting Hyper-V up and running, followed by best practices for building a larger, fault-tolerant solution using System Center Virtual Machine Manager 2008. This hands-on guide explains how to migrate physical systems to the virtual environment; use System Center Operations Manager; and secure, back up, and restore your Hyper-V solution.

Plan and implement a Hyper-V installation
Configure Hyper-V components 
Install and configure System Center Virtual Machine Manager 2008
Create and manage virtual machines 
Back up and restore virtual machines 
Monitor, back up, and restore the virtual solution
Secure your Hyper-V environment
Understand the virtual desktop infrastructure
Use third-party virtualization tools for Hyper-V 


Table of contents
1 Virtualization Overview
2 Planning and Installation
3 Configuring Hyper-V Components
4 Planning and Designing Systems Center Virtual Machine Manager 2008
5 Installing and Configuring Systems Center Virtual Machine Manager 2008
6 Configuring Systems Center Virtual Machine Manager 2008
7 Creating and Managing Virtual Machines
8 Managing Your Virtual Machines
9 Backing Up, Restoring, and Disaster Recovery for Your Virtual Machines
10 Monitoring Your Virtual Solution
11 Hyper-V Security
12 Virtual Desktop Infrastructure
A Third Party Virtualization Tools for Hyper-V
B Windows Server 2008 Hyper-V Command Line Reference
Detection and identification of mycobacteria in the Lisbon water distribution system (2005)

Mycobacteria have emerged as a major cause of opportunistic infections. Until the present, only a few studies have characterized mycobacteria present in the water distribution system of urban areas. In this study, we characterize these microorganisms in the Lisbon water distribution system. Our results indicate a high rate of positivities (90.5%) with mainly saprophytic mycobacteria. Around 63% of these results belong to strains of Mycobacterium gordonae indicating a generalized proliferation of this species in the Lisbon water distribution system. A total of 21.05% of the isolates are from M. kansasii, M. intracellulare and M. chelonae.