gebhart/patrepeval huggingface dataset:
Identification in <i>Listeria monocytogenes</i> of MecA, a Homologue of the <i>Bacillus subtilis</i> Competence Regulatory Protein (2000)

We identified in Listeria monocytogenes a gene encoding a protein homologous to MecA, a regulatory protein acting with ClpC and ComK in the competence pathway of Bacillus subtilis. In L. monocytogenes, MecA is involved, along with ClpC and ClpP, in the downregulation of a 64-kDa secreted protein. In B. subtilis, the MecA protein of L. monocytogenes behaves as a regulatory protein, controlling the transcription of comK and comG. Complete or disrupted ComK homologues were also found in L. monocytogenes. However, we failed to detect competence in various strains of L. monocytogenes, including those with intact ComK. Our results suggest that the functions of MecA in the saprophytes L. monocytogenes and B. subtilis have presumably diverged in response to their respective ecological niches.
Generation of an <i>OMgp</i> allelic series in mice (2009)

The very limited ability to regenerate axons after injury in the mature mammalian central nervous system (CNS) has been partly attributed to the growth restrictive nature of CNS myelin. Oligodendrocyte myelin glycoprotein (OMgp) was identified as a major myelin-derived inhibitor of axon growth. However, its role in axon regeneration in vivo is poorly understood. Here we describe the generation and molecular characterization of an OMgp allelic series. With a single gene targeting event and Cre/FLP mediated recombination, we generated an OMgp null allele with a LacZ reporter, one without a reporter gene, and an OMgp conditional allele. This allelic series will aid in the study of OMgp in adult CNS axon regeneration using mouse models of spinal cord injury. The conditional allele will overcome developmental compensation when employed with an inducible Cre, and allows for the study of temporal and tissue/cell type-specific roles of OMgp in CNS injury-induced axonal plasticity.
Distonic oxonium and ammonium radical cations. A neutralization-reionization and collisional activation study (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDistonic oxonium and ammonium radical cations. A neutralization-reionization and collisional activation studyChrysostomos Wesdemiotis, Paul O. Danis, Rong Feng, Jacqueline Tso, and Fred W. McLaffertyCite this: J. Am. Chem. Soc. 1985, 107, 26, 8059–8066Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/ja00312a044https://doi.org/10.1021/ja00312a044research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Radiation Damage Mechanisms as Revealed Through Electron Spin Resonance Spectroscopy (1972)

Following a major shortage of 99Mo in the 2009–2010 period, concern grew that the aging reactor production facilities needed to be replaced. Most producers were using highly enriched 235U (HEU) as the target material. The Organisation for Economic Co-...Read More
Entity Disambiguation for Wild Big Data Using Multi-Level Clustering (2015)

When RDF instances represent the same entity they are said to corefer. For example, two nodes from different RDF graphs 1 both refer to same individual, musical artist James Brown. Disambiguating entities is essential for knowledge base population and other tasks that result in integration or linking of data. Often however, entity instance data originates from different sources and can be represented using differ- ent schemas or ontologies. In the age of Big Data, data can have other characteristics such originating from sources which are schema-less or without ontological structure. Our work involves researching new ways to process this type of data in order to perform entity disambiguation. Our approach uses multi-level clustering and includes fine-grained entity type recognition, contextualization of entities, online processing of which can be supported by a parallel architecture.
Effect of Larger Ablation Zone and Transition Zone on Corneal Optical Aberrations After Photorefractive Keratectomy (2001)

Evaluating the postoperative corneal aberration structure will help us devise ways to minimize the wavefront aberrations of the eye through the creation of an ideal corneal first surface, thereby improving visual results for patients undergoing excimer laser ablations for refractive correction.
Inverse Identification of the Constitutive Equation of Inconel 718 and AISI 1045 from FE Machining Simulations (2013)

Until now, the progress, which was achieved in the field of computer technology, could not be used to broadly introduce FEM-modeling techniques in the machining sector of the manufacturing industry. Despite the potentials of modeling cutting processes with the FEM, such as predicting tool loads and chip forms, there are obstacles, which hinder a successful adoption. One of the most challenging aspects is the modeling of the viscoplastic workmaterial behaviour during machining processes. In the past expensive and time-consuming exper- iments like the Split-Hopkinson Pressure Bar Test were used to obtain material data at the extreme conditions of cutting (T close to Tmelt, strains ∼ 5, strain rates > 106). New, inverse methods of identifying the flow stress data are faster, easier to execute and potentially more accurate. This paper applies a new methodology to inversely identify the flow stress data in orthogonal cutting, which was originally developed at the ISM of the University of Kentucky, USA, and the WZL of RWTH Aachen University, Germany. The derived method is applied to identify the flow stress data of Inconel 718 and steel AISI 1045 in order to create 2D FE-models of the orthogonal cutting process for various cutting conditions. The models are validated by experiments on a specially designed test set-up on a broaching machine, which is distinguished by other orthogonal cutting tests by the straight geometry of the workpiece, which allows a direct comparison with 2D FE- simulations. The experiments include highspeed-filming the chip formation, measuring the cutting forces and temperatures.
A segment and epithelium specific messenger ribonucleic acid fragment up-regulated by estradiol in the rat oviduct (2001)

Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual hace más accesibles los libros digitales de tema americanista a los investigadores y usuarios interesados de cualquier parte del mundo.
Exploratory Clinical Trial to Evaluate the Efficacy of a Topical Traditional Chinese Herbal Medicine in Psoriasis Vulgaris (2015)

Objective. To evaluate the efficacy and safety of herbal ointment, Shi Du Ruan Gao, in patients with plaque-type psoriasis. Design. Single-center, randomized, investigator-blinded, parallel group, placebo-controlled study. Participants. One hundred outpatients with mild to moderate chronic plaque-type psoriasis were enrolled. Intervention. The patients applied either Shi Du Ruan Gao ointment or vehicle ointment topically to for 8 weeks. Main Outcome Measures. The outcomes were assessed using the following criteria: Total Severity Score (TSS, sum of erythema, scaling, and plaque elevation/induration, on a 0 to 4 scale), Investigator Global Assessment (IGA) evaluated on a 0 (Clear) to 4 (s to very severe) scale, and Global Subjects' Assessment of treatment response on a 7-point scale from -1 (worse) to 5 (Cleared). Results. Significant reductions in the Total Severity Score (P < 0.001) (mean score: 2.7 after Shi Du Ruan Gao treatment versus 5.1 in control subjects). Both Investigator Global Assessment (IGA) and Global Subjects' Assessment of treatment are better in the Shi Du Ruan Gao group than the control group (P < 0.001). Conclusion. Shi Du Ruan Gao ointment was a safe, and effective therapy for plaque-type psoriasis.
Long-term plasticity may be manifested as reduction or expansion of cortical representations of actively used muscles in motor skill specialists (2013)

Our aim was to study long-term plasticity in the organization of cortical muscle representations due to extensive motor training for different skills. We were especially interested in whether skill-specific demands on independent hand muscle movements and synchronous leg muscle movements are reflected differently in the reorganization of muscle representations. We used navigated transcranial magnetic stimulation to estimate the size of cortical representations of opponens pollicis, abductor digiti minimi, and tibialis anterior muscles in five string instrument players, five figure skaters, and five controls. The extent of the representation area was presented as an amplitude-area curve showing the spatial distribution of motor evoked potentials. The size of representation areas was compared between the dominant and nondominant hemispheres and between the groups. The representation area of the left abductor digiti minimi (critical for reaching right tones) in the right, nondominant hemisphere was smaller in string players and the representation area of the tibialis anterior in the dominant hemisphere (critical for jumps) was larger in figure skaters when compared with controls. Reorganization in the motor cortex may differ depending upon the skill and an individual muscle's role in the skill. A smaller representation area of the independently used hand muscle in masters of fine motor skills may reflect long-term plasticity toward more focused representation, which may be beneficial in accurate and discrete cortical control of the muscle. Larger cortical representations are related to skill demanding coactivation of proximal and distal lower limb muscles.
Distance Estimation in a 3-D Imaging Display (2001)

Abstract Imaging displays have lacked several characteristics of direct vision such as true stereopsis, and this may in part account for some loss in visual performance when compared with direct vision. One such decrement in performance is in judgments of distance. An experiment is reported in which judgments of distance of targets were obtained from videotaped images of targets in a natural outdoor scene. Presentations were made under 3 conditions: stereo with near or far zero disparities and binocular nonstereo ("biocular") viewing. Underconstancy was found to be less for stereo presentation, but only when the point of zero disparity was in the plane of presentation of the virtual image. Some implications for the design of cockpit imaging displays are discussed.
The Department of Chemistry, ETH Zürich, in the New Hönggerberg Buildings (2001)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
Kaulų gigantinių cistų gydymo taktika (1994)

Lietuvos sveikatos mokslų universitetas (302536989)
New antihistaminic agents: Synthesis and evaluation of h<sub> 1</sub> -antihistaminic actions of 3-[(n,n-dialkylamino)alkyl)-1,2,3,4-tetrahydro-(1h)-thioquinazolin-4(3h)-ones and their oxo analogues (2007)

The synthesis of eight new 3-[(N,N-dialkylamino)allkyl]-2(1H)-thioquinazolin-4(3H)-ones (3a-d) and their oxo analogues (4a-d) has been described. H 1 -Antihistaminic activities have been evaluated using in vitro and in vivo standard animal models in comparison to chlorpheniramine maleate as reference drug. Among the test compounds, 3d was found to be the most potent with an IC 50 value of 1.23 µM (in vitro) offering 70.24% protection in vivo .
Nearfield Hydrodynamic Interactions of Ships in Shallow Water (1977)

The hydrodynamic interactions of two vessels moving at the same speed in nearfield is considered by applying the slender-body theory. It is shown that, for a water depth that is the same order as the beam of the vessel, the problem reduces to a sequence of inner problems in the cross-flow plane. This reduction to strip-theory allows one to obtain the solution without the necessity of solving an outer problem. Applications were made to two pairs of ship models. Theoretical predictions generally are high as compared with available experimental measurments, but offer a fairly satisfactory qualitative description of the interaction phenomenon when the length of the overlap of the vessels is large as compared with the separation.
Feasibility of Using External Jugular Vein and Its Branches as Y- and X-Shaped Vein Grafts for Bridging of Arterial Defects and Providing Additional Arterial Sources for Free Flap Applications in Rat Model (2014)

These vein grafts can be used as an alternative technique for reconstruction of tissue defects that require arterial gap repair with single or multiple free flap applications and also as a new microsurgical training model.
Nanotechnology Based on Spatially Fixed ds DNA (RNA) Molecules (2005)

We describe the formation and the properties of a nanoconstruction that consists of the double-stranded molecules of nucleic acids (or synthetic polynucleotides) located at a distance of 35 A in the spatial structure of particles of their cholesteric liquid-crystalline dispersion and crosslinked by artificial nanobridges. The resulting nanostructures possess the peculiar physicochemical properties.
Heat Capacities from 1 to 30 K of Zn, Cd, Sn, Bi, and Y (1969)

The specific heats of the anisotropic metals zinc, cadmium, tin, bismuth, and yttrium have been measured from 1 to 30 K with an accuracy in most instances of 0.5%. Each of these materials showed a relatively rapid decrease in equivalent ${\ensuremath{\Theta}}_{D}$ with increasing temperature, a characteristic of anisotropic solids. The present results are in agreement with other similar quality data where overlaps exist. The results for the yttrium sample are somewhat ambiguous because of the existence of an anomaly which becomes important below 4 K and which is believed to be due to magnetic ordering of the rare-earth and transition-metal impurities in the sample. Low-temperature parameters, tabulated smoothed results, and reduced ${\ensuremath{\Theta}}_{D}(T)$ plots are given for each of these metals.
CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue (2023)

Taken together, hCLARITY enables research of the human brain with high sensitivity and down to sub-diffraction resolution. It therefore has enormous potential for the investigation of local morphological changes, e.g., in neurodegenerative diseases.
Getting consistent results from comparative analysis of RNA_Seq data from single patients. (2018)

e24194 Background: The Treehouse Childhood Cancer Initiative uses RNA-Seq to measure gene expression in tumors from kids with relapses to identify potentially druggable, activated pathways. RNA-Seq results are more consistent among samples that are more deeply sequenced, and measurements of highly expressed genes are more consistent than others. Methods: Data from eight deeply sequenced tumors (
Crystal Structure of the Antigen-Binding Fragment of Apoptosis-Inducing Mouse Anti-Human Fas Monoclonal Antibody HFE7A (2002)

Binding of Fas ligand to Fas induces apoptosis. The Fas-Fas ligand system plays important roles in many biological processes, including the elimination of autoreactive lymphoid cells. The mouse anti-human Fas monoclonal antibody HFE7A (m-HFE7A), which induces apoptosis, has been humanized based on a structure predicted by homology modeling. A version of humanized HFE7A is currently under development for the treatment of autoimmune diseases such as rheumatoid arthritis. For a deeper understanding of the protein engineering aspect of antibody humanization, for which information on the three-dimensional structure is essential, we determined the crystal structure of the m-HFE7A antigen-binding fragment (Fab) by X-ray crystallography at 2.5 A resolution. The main-chain conformation of the five loops in the six complementarity-determining regions (CDRs) was correctly predicted with root-mean-square deviations of 0.30-1.04 A based on a comparison of the crystal structure with the predicted structure. The CDR-H3 conformation of the crystal structure, which was not classified as one of the canonical structures, was completely different from that of the predicted structure but adopted the conformation which followed the "H3-rules." The results of charge distribution analysis of the antigen-binding site suggest that electrostatic interactions may be important for its binding to Fas.
Clinical and subclinical dopaminergic dysfunction in PARK6‐linked parkinsonism: An <sup>18</sup>F‐dopa PET study (2002)

PARK6, a locus for early-onset recessive parkinsonism, has been causally implicated in nine unrelated families from four different countries. The gene is still unidentified and hence the importance of PARK6 as a cause of Parkinson's disease is unknown. To date, no pathology or functional imaging studies are available on PARK6-linked parkinsonism. We have used (18)F-dopa positron emission tomography to study four patients who are homozygous and three asymptomatic relatives who are heterozygous for PARK6. The clinically affected PARK6 subjects had a similar 85% reduction in posterior dorsal putamen (18)F-dopa uptake to a group of idiopathic Parkinson's disease patients matched for clinical disease severity and duration but showed significantly greater involvement of head of caudate and anterior putamen. The group of asymptomatic PARK6 carriers showed a significant mean 20 to 30% reduction in caudate and putamen (18)F-dopa uptake in comparison with controls, individual values falling toward the bottom of the normal range. Our results indicate that PARK6 pathology results in a more uniform loss of striatal dopamine terminal function than Parkinson's disease. The subclinical loss of striatal dopamine storage capacity found in the PARK6 carriers implies that the unidentified gene on the short arm of chromosome 1 exhibits either haploinsufficency or a dominant negative effect.
A Goal Reasoning Agent for Controlling UAVs in Beyond-Visual-Range Air Combat (2017)

We describe the Tactical Battle Manager (TBM), an intelligent agent that uses several integrated artificial intelligence techniques to control an autonomous unmanned aerial vehicle in simulated beyond-visual-range (BVR) air combat scenarios. The TBM incorporates goal reasoning, automated planning, opponent behavior recognition, state prediction, and discrepancy detection to operate in a real-time, dynamic, uncertain, and adversarial environment. We describe evidence from our empirical study that the TBM significantly outperforms an expert-scripted agent in BVR scenarios. We also report the results of an ablation study which indicates that all components of our agent architecture are needed to maximize mission performance.
Non-contacting Seals in Screw Compressors (2014)

Screw compressors are currently the most frequently used compressor type in the field of industrial compressed air production. Because end products are only allowed to come into contact with absolutely clean compressed air in many fields of industry, there is a considerable demand on the market for the production of compressed air that is entirely oil-free. The high acquisition costs of dry-running compressor systems and the disadvantages in energy terms compared to oil-injected designs need to be offset by a long useful life and guaranteed reliability. The compressor's integrated sealing system makes an important contribution here. High peripheral speeds and pressure differences largely rule out the use of simple, contacting seal systems and drive forward continuous optimization in relation to function and production costs. Based on the calculation of compressible outflows at annular gaps and experimental studies, the sealing performance of various gas choke seals for use in screw compressors will be analyzed and evaluated. Here, the main criteria of pressure reduction and barrier effectiveness, as well as the size and geometric complexity of the seal will be considered. This paper shows that the flows simulated with the help of a chamber model, using pressure-dependent flow coefficients and overflow factors, allow a good comparison in qualitative terms with the real, measured permeability curve for designing sealing systems for dry-running screw compressors.
Approximating the Quadratic Transportation Metric in Near-Linear Time (2018)

Computing the quadratic transportation metric (also called the $2$-Wasserstein distance or root mean square distance) between two point clouds, or, more generally, two discrete distributions, is a fundamental problem in machine learning, statistics, computer graphics, and theoretical computer science. A long line of work has culminated in a sophisticated geometric algorithm due to Agarwal and Sharathkumar in 2014, which runs in time $\tilde{O}(n^{3/2})$, where $n$ is the number of points. However, obtaining faster algorithms has proven difficult since the $2$-Wasserstein distance is known to have poor sketching and embedding properties, which limits the effectiveness of geometric approaches. In this paper, we give an extremely simple deterministic algorithm with $\tilde{O}(n)$ runtime by using a completely different approach based on entropic regularization, approximate Sinkhorn scaling, and low-rank approximations of Gaussian kernel matrices. We give explicit dependence of our algorithm on the dimension and precision of the approximation.
pH measurements in non-aqueous and mixed solvents: Predicting pH(PS) of potassium hydrogen phthalate for alcoholwater mixtures (Technical Report) (1998)

Abstract
Liquid and Vapor Phase Growth of III-V Materials for Photonic Devices (1989)

Precisely controlled epitaxial growth of microscopically thin semiconductor layers is essential for lightwave source and detector components. Achieving precise control while simultaneously meeting manufacturing volume and cost requirements is a demanding challenge. We are meeting that challenge with the development of advanced liquid and vapor phase epitaxial growth technologies. In this article we provide a review of the principles, a brief description of the state-of-the-art implementation, and a discussion of the advantages and limitations of the four epitaxial techniques we use — liquid phase epitaxy, trichloride and hydride vapor phase epitaxy, and metal-organic chemical vapor deposition epitaxy.