gebhart/patrepeval huggingface dataset:
A comparative evaluation of ELISAs for D-dimer and related fibrin(ogen) degradation products (1993)

This study was designed to (i) characterize two new monoclonal antibodies that react with neoepitopes on fibrin(ogen) fragments D-dimer and D1 and (ii) compare the specificity of these antibodies with that of two commercially available 'D-dimer' ELISAs [Dimertest EIA (American Diagnostica, Inc.) and Asserachrom D-Di (Diagnostica Stago)] and also with an ELISA for fibrinolytic fragments containing the E domain complexed with a D (or D-dimer) moiety [Fibrinostika FbDP (Organon Teknika)]. All assays were in a capture (sandwich) ELISA format. Fibrin(ogen) degradation products were isolated in high yield by a novel method involving hydrophobic interaction chromatography. The results disclosed considerable differences in sensitivity and specificity for purified fibrinolytic fragments among all five ELISAs. Although the diagnostic utility of monitoring plasma fibrinolytic fragments is not questioned, our results provide a rational basis for understanding why mAb-based ELISAs for these analytes are not well correlated. If, as our data suggest, the D-dimer ELISAs are not actually measuring the same analytes, then interpretation of studies that determine D-dimer concentrations with different methods will be problematic and standardization of D-dimer measurements across assays will be impossible.
Cellular Immunity as a Potential Cause of Local Reactions to Booster Vaccination With Diphtheria and Tetanus Toxoids and Acellular Pertussis Antigens (2009)

CMI to vaccine antigens was often detectable in children before preschool booster vaccination and preliminary evidence suggests a role for CMI in local reactions to this dose.
Reaction of carbon monoxide at atmospheric pressure with trialkylboranes in the presence of lithium trimethoxyaluminohydride. Convenient procedure for the conversion of olefins into aldehydes via hydroboration (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of carbon monoxide at atmospheric pressure with trialkylboranes in the presence of lithium trimethoxyaluminohydride. Convenient procedure for the conversion of olefins into aldehydes via hydroborationHerbert Charles Brown, Randolph A. Coleman, and Michael W. RathkeCite this: J. Am. Chem. Soc. 1968, 90, 2, 499–501Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/ja01004a055https://doi.org/10.1021/ja01004a055research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: A UNIFIED APPROACH TO PROSTANOID AND CORTICOSTEROID SYNTHONS (1984)

Abstract Die Herstellung von Synthonen für Desoxyprostanoide und "Ketosteroide wird beschrieben.
Diet can influence the ability of nicotinamide to prevent diabetes in the non-obese diabetic mouse: a preliminary study (1999)

Altering dietary patterns using sucrose can affect the ability of NA to prevent diabetes in the NOD mouse. This finding may be relevant for human studies with NA aimed at preventing Type 1 DM and suggests that diet may need to be monitored or even controlled in these studies.
Silver Trifluoromethanesulfonate(Triflate) Activation of Trichloroacetimidates in Glycosylation Reactions (1993)

Abstract Chemical syntheses of biologically active oligosaccharides, glycolipids and glycopeptides requires efficient stereospecific glycosylation reactions.2 One of the most effective glycosylation methods involves activation of anomeric imidates, particularly mchloroacetimidates, by Lewis acids such as boron trifluoride etherate (BF3·OEt2), mmethylsilyl mfluoromethanesulfonate (TMSOTF)3 and mfluoromethanesulfonic anhydride.4 In a recent example from this laboratory, BF3·OEt2, has been used to promote the glycosylation of methyl 2,3,6-tri-O-benzoyl-B-D-galactopyranoside (I)5 with 2-deoxy-2-phthalimido-3,4,6-tri-O-acetyl-B-D-galactopyranosyl mchloroacetimidate (I): see Scheme 1. The expected β1-4-linked disaccharide III was obtained in 40% yield. The yield was so low since both the α-anomer and a 1-3-linked disaccharide were formed as by products, the latter in particularly large quantities (cf. Ref.7). The 1-3 disaccharide could be formed from a product of acid-catalyzed 3,4-migration of the benzoyl group which is not surprising, considering the cis relationship of the 3,4-hydroxyl groups in galactose.8 In fact, when the glycosylation reaction was quenched before all unreacted alcohol was consumed, the chromatographic fraction corresponding to the starting alcohol II contained at least three different tribenzoates (as shown by NMR analysis).9 Other promoters, ZnBr2 10 and TMSOTF, led to lower yields and more complicated mixtures than BF3·OEt2.
VP20.05: Umbilico‐porto‐systemic shunt and fetal growth restriction: a novel etiology or guilty by association? A lesson from a prospective study (2021)

to determine the prevalence of fetal umbilico-porto-systemic venous shunts (UPSVS) in fetal growth restriction (FGR); to compare the perinatal outcome in FGR pregnancies with and without UPSVS; to determine the association between UPSVS and other anomalies in growth restricted fetuses. A prospective cross-sectional study of all pregnancies diagnosed with FGR according to the Delphi survey expert consensus (2016). All participants underwent a detailed anomaly scan, including a targeted scan of the fetal portal system. Shunts detected using colour Doppler were classified as extra- hepatic, intra-hepatic or umbilico-systemic. Perinatal outcome was compared between cases with and without UPSVS. 99 cases of FGR were included. The prevalence of UPSVS in our cohort was 8% (8/99). The median gestational age (GA) of FGR diagnosis and GA at delivery were 32.6 (IQR: 28.9-36.6) vs. 33.6 (30.3-35.5) (p = 0.82) and 35 (31.1-37.4) vs. 37 (35.3-37.3) (p=0.40) weeks, in the shunt and non-shunt group, respectively. The rate of preterm delivery was 50% vs. 46% (p = 0.83), in the shunt vs. non-shunt groups. Associated fetal vascular anomalies were significantly higher in the shunt group (50% vs. 8.8% p = 0.001). The rate of other associated anomalies was similar. The shunt group had a lower rate of abnormal uterine artery Doppler (0% vs. 40.7% p = 0.03). Other Doppler indices and NICU admission rates had non-significant difference. There was one case of stillbirth in each group, and one case of genetic aberration in the entire study population. UPSVS is a relatively common finding in growth restricted fetuses. Meticulous sonographic evaluation of the portal system and other vascular anomalies should be considered in the prenatal workup of FGR, as UPSVS may have implications during infancy and childhood, Short term perinatal outcome is comparable between FGR fetuses with and without UPSVS.
Experimental Demonstration of Space-Time Coding for MDL Mitigation in Few-Mode Fiber Transmission Systems (2017)

We demonstrate through experimental measurements the potential of Space-Time coding in mitigating mode-dependent loss (MDL) in few-mode fiber transmission systems. The Q-factor is improved by 3.4 dB for an MDL of 10 dB.
Intraspecific bovine herpesvirus 1 recombinants carrying glycoprotein E deletion as a vaccine marker are virulent in cattle (2006)

Vaccines used in control programmes of Bovine herpesvirus 1 (BoHV-1) utilize highly attenuated BoHV-1 strains marked by a deletion of the glycoprotein E (gE) gene. Since BoHV-1 recombinants are obtained at high frequency in experimentally coinfected cattle, the consequences of recombination on the virulence of gE-negative BoHV-1 were investigated. Thus, gE-negative BoHV-1 recombinants were generated in vitro from several virulent BoHV-1 and one mutant BoHV-1 deleted in the gC and gE genes. Four gE-negative recombinants were tested in the natural host. All the recombinants were more virulent than the gE-negative BoHV-1 vaccine and the gC- and gE-negative parental BoHV-1. The gE-negative recombinant isolated from a BoHV-1 field strain induced the highest severe clinical score. Latency and reactivation studies showed that three of the recombinants were reexcreted. Recombination can therefore restore virulence of gE-negative BoHV-1 by introducing the gE deletion into a different virulence background.
Transfer of thyroiditis with spleen cells from mice immunised with recombinant human thyrotropin receptor (TSHR) (1995)

info:eu-repo/semantics/nonPublished
CvfA Protein and Polynucleotide Phosphorylase Act in an Opposing Manner to Regulate Staphylococcus aureus Virulence (2014)

We previously identified CvfA (SA1129) as a Staphylococcus aureus virulence factor using a silkworm infection model. S. aureus cvfA-deleted mutants exhibit decreased expression of the agr locus encoding a positive regulator of hemolysin genes and decreased hemolysin production. CvfA protein hydrolyzes a 2',3'-cyclic phosphodiester bond at the RNA 3' terminus, producing RNA with a 3'-phosphate (3'-phosphorylated RNA, RNA with a 3'-phosphate). Here, we report that the cvfA-deleted mutant phenotype (decreased agr expression and hemolysin production) was suppressed by disrupting pnpA-encoding polynucleotide phosphorylase (PNPase) with 3'- to 5'-exonuclease activity. The suppression was blocked by introducing a pnpA-encoding PNPase with exonuclease activity but not by a pnpA-encoding mutant PNPase without exonuclease activity. Therefore, loss of PNPase exonuclease activity suppressed the cvfA-deleted mutant phenotype. Purified PNPase efficiently degraded RNA with 2',3'-cyclic phosphate at the 3' terminus (2',3'-cyclic RNA), but it inefficiently degraded 3'-phosphorylated RNA. These findings indicate that 3'-phosphorylated RNA production from 2',3'-cyclic RNA by CvfA prevents RNA degradation by PNPase and contributes to the expression of agr and hemolysin genes. We speculate that in the cvfA-deleted mutant, 2',3'-cyclic RNA is not converted to the 3'-phosphorylated form and is efficiently degraded by PNPase, resulting in the loss of RNA essential for expressing agr and hemolysin genes, whereas in the cvfA/pnpA double-disrupted mutant, 2',3'-cyclic RNA is not degraded by PNPase, leading to hemolysin production. These findings suggest that CvfA and PNPase competitively regulate RNA degradation essential for S. aureus virulence.
Residual Obstructive Sleep Apnea in Children Less Than 3 Years of Age after Undergoing an Adenotonsillectomy (2011)

Objective Obstructive sleep apnea (OSA) is the leading reason for adenotonsillectomy in children. We aimed to evaluate polysomnographic characteristics of OSA in children under 3 years of age and, in a subset of these children who had pre‐ and postoperative sleep studies, potential persistence of OSA after adenotonsillectomy. Method We performed a retrospective chart review of children. Results A total of 283 children underwent a preoperative polysomnogram, and 70 had both pre‐ and postoperative polysomnograms. Their average age was 20.3 + 0.8 months. Adenotonsillectomy resulted in a significant reduction in apnea hypopnea index (AHI) from 34.8 + 4.8 to 5.7 + 1.6 events/hr (p + 1% to 89 + 0.8%) (p1 and 21% had an AHI>5). The only predictor of persistent OSA was the preoperative AHI, which was higher for the group with residual OSA (55+50) compared to the group without it (29 + 36) ( P =. 02). Conclusion Adenotonsillectomy results in a significant improvement in OSA in children.
Development of Highly Selective Ligands for Separations of Actinides from Lanthanides in the Nuclear Fuel Cycle (2011)

This account summarizes recent work by us and others on the development of ligands for the separation of actinides from lanthanides contained in nuclear waste streams in the context of a future European strategy for nuclear waste management. The current status of actinide/lanthanide separations worldwide is briefly discussed, and the synthesis, development, and testing of different classes of heterocyclic soft N- and S-donor ligands in Europe over the last 20 years is presented. This work has led to the current benchmark ligand that displays many of the desirable qualities for industrial use. The improvement of radiolytic stability through ligand design is also discussed.
Two-zero four-pole building block for microwave waveguide filters using all-resonant modes at their cutoff frequency (2003)

This article describes a basic building block for microwave waveguide filters. It uses a new coupling scheme where all resonant modes are used at their cutoff frequency. It is composed of a cascade of basic nonloaded rectangular cavities where the modes are alternately single mode and dual mode. These cavities are coupled directly, without any iris. Neither coupling nor tuning screws are needed. The analysis of the discontinuities is performed by the method of moments (MoM). The synthesis makes use of an optimization method based on the genetic algorithm. Prototypes have been realized and measurements are shown to confirm the analysis results. © 2003 Wiley Periodicals, Inc. Int J RF and Microwave CAE 13: 429–437, 2003.
Variable penetrance of hypogonadism in a sibship with Kallmann syndrome due to a deletion of the KAL gene (1995)

We report on the clinical and molecular characterization of 3 sibs with X-linked ichthyosis and variable expression of Kallmann syndrome. One of the affected brothers had mild hyposmia and showed normal pubertal progression. However, we demonstrated the same partial deletion of the X-linked Kallmann gene, sparing the first exon in the mildly affected patient as well as in one of his severely affected brothers.
One-Step Grignard Reactions with Dimethylaminopropyl Chloride: Application to the Synthesis of Tricyclic Drugs (1981)

Abstract The routine synthesis employed for many drugs bearing an alkylamine residue (e.g. tricyclic antidepressants(1), some anti-malarials(2), diphenidol(3)) is the Grignard reaction between a tertiary α,ω-chloroalkylamine and an aromatic ketone (Scheme I). However, Grignard reagents of short chain chloroalkylamines are difficult to prepare(4). These difficulties stem from the inductive deactivation effect of the nitrogen on the carbon-halogen bond, and from the instability of these free-base amines and their magnesium complexes. Decomposition products tend to coat the magnesium and quench the reaction. Marxers' Grignard-reaction conditions(5) are still currently used(1), althouth reports on irreproducibility and failures have subsequently appeared(2). We wish to report a substantially modified Grignard reaction procedure for the syntheses of the above mentioned type of compounds. The main changes from the “normal” Grignard reaction were the utilization of Barbier's(6) ‘one-step’ concept(7) and the isolation o f remarkable stable magnesium complexes(2)(8). High reproducibility and superior-purity of the products so obtained, made this procedure the method of choice in our laboratory.
Analyse statistique de comportements d'élèves en algèbre (2003)

Nous presentons une analyse de comportements d'eleves qui ont resolu des exercices d'algebre avec le logiciel Aplusix. Nous avons realise un logiciel produisant des statistiques, a partir des protocoles (fichiers enregistrant les interactions eleve-logiciel), au niveau de la justesse des etapes de calcul et des resolutions. Nous avons particulierement etudie les activites de classes de seconde et de premiere S. Cette etude fait ressortir les variables didactiques qui entrent en jeu dans les types d'exercices choisis (qui sont des types tres classiques). Elle montre que le niveau de technicite algebrique des eleves est assez faible par rapport a ce que l'on peut attendre a ce moment de leur apprentissage. Nous avons aussi analyse ces donnees statistiques avec des techniques de classification automatique (clustering), dans le but de deceler des categories d'eleves.
Collagen–silica hybrid materials: Sodium silicate and sodium chloride effects on type I collagen fibrillogenesis (2005)

Collagen-silica hybrid materials have been considered for potential biomedical applications. Understanding of the collagen-silica interactions is the key to control hybrids structure and properties. For this purpose, the effect of sodium silicate and sodium chloride addition at two concentrations, 0.83 and 10 mM, on the kinetic of the type I collagen fibrillogenesis at 20 degrees C, and pH 7.4 were studied. Absorbance profiles of fibrillogenesis experiments were collected together with measures of silicic acid concentration and transmission electron microscopy analysis. The specific effect of silica addition on the collagen fibrils self-assembly mechanisms was demonstrated by comparison with the sodium chloride. Sodium silicate at 10 mM inhibited the collagen fibrillogenesis. At the same concentration, the sodium chloride decreased the rate of the collagen fibril assembly. Collagen fibrillogenesis kinetic was not significantly disturbed by the presence of 0.83 mM of sodium chloride. However, the same concentration of sodium silicate modified the collagen fibrillogenesis kinetic. Transmission electron microscopy indicated for experiment with 0.83 mM of sodium silicate, the formation of longer and wider fibrils than for the equivalent collagen fibrillogenesis experiment with sodium chloride. The effect of sodium chloride is explained in terms of osmotic exclusion and influence on electrostatic interactions between collagen fibrils. The specific involvement of silicic acid in collagen helices hydrogen-bond interactions is suggested. Finally, the results of this study are discussed regarding the preparation of composites by co-gelation of type I collagen and sodium silicate, for potential application as bone repair device.
Design, fabrication, and performance of high-speed monolithically integrated InAlAs/InGaAs/InP MSM/HEMT photoreceivers (1997)

A detailed study of the performance of monolithically integrated photoreceivers based on metal-semiconductor-metal (MSM) photodetectors (PD's) and HEMT's is undertaken. Two different stacked-layer approaches to integrating MSM-PD's with HEMT's are investigated, and the performance of detectors and HEMT's for each approach is compared. The structure with the MSM layers grown on top of the HEMT layers exhibited the best overall performance. A physics-based MSM model is developed and incorporated into microwave circuit design software; excellent agreement between circuit simulations and measured frequency responses is demonstrated. To evaluate the effects of MSM electrode geometry and detector area on photoreceiver performance, photoreceivers with MSM interelectrode spacings of 1, 1.5, and 2 /spl mu/m were fabricated and characterized. The electrical amplifier used in the photoreceivers is a two-stage, variable-transimpedance amplifier with a common-gate HEMT as the feedback path. By adjusting the DC voltage applied to the gate of this feedback HEMT, transimpedances ranging from 55.8 to 38.1 dB/spl Omega/, with corresponding -3 dB cutoff frequencies from 6.3 to 18.5 GHz, were measured experimentally. Excellent noise performance has been measured, with average input noise current spectral densities of 7.5, 8, and 12 pA/Hz/sup 1/2/ obtained for bandwidths of 6.3, 8, and 13.7 GHz, respectively. A packaged receiver has been tested at 5 Gb/s and an open eye pattern obtained.
ChemInform Abstract: CONTRIBUTION TO THE PROBLEM OF NUCLEOPHILIC SUBSTITUTION REACTIONS AT SMALL‐RING CARBON ATOMS OCCURRING WITH RETENTION OF CONFIGURATION (1976)

Abstract In Aceton läßt sich weder mit NaJ noch mit Tetraäthylammoniumacetat eine nucleophile Bromsubstitution im Dion (I) erreichen.
Interaction of TiS<sub>2</sub>and Sulfur in Li-S Battery System (2017)

With the ability to adsorb polysulfide, electronically conductive and electrochemically active TiS<sub>2</sub> is an effective multifunctional cathode additive to improve Li-S battery cycling performance. Furthermore, by using X-ray Photoelectron Spectroscopy (XPS), direct evidence is obtained to demonstrate the strong interaction between Li-polysulfide and TiS<sub>2</sub>. The observation of Li signature on Li<sub>2</sub>S<sub>8</sub> treated TiS<sub>2</sub> proves that the TiS<sub>2</sub> possesses the ability to adsorb Li-polysulfides species on its surface. An electron density transfer from Ti to Li and S is identified based on the positions of the peaks in the XPS spectrum before and after the interaction, which is consistent with the theoretically predicted polysulfide-TiS<sub>2</sub> interaction models in the literature. TiS<sub>2</sub> sample with 2.5x higher BET surface area is obtained by milling the raw TiS<sub>2</sub> particles and used as cathode additive in the sulfur electrode. Furthermore, in the presence of TiS<sub>2</sub> additive, long cycle life and improved sulfur utilization of Li-S cells under high rate discharge are demonstrated. In addition, we find that a uniform TiS<sub>2</sub> distribution in the sulfur-TiS<sub>2</sub> hybrid electrode is vital in determining its effectiveness in enhancing the performance of sulfur electrodes. Thus, by processing method and condition should be very important considerations in future development of sulfur electrodes with TiS<sub>2</sub> additive.
Image-converter recording of picosecond pulses emitted by an erbium laser (λ=2.94 μ) with active mode locking (1983)

An image converter with a silver–oxygen–cesium photocathode (the red edge of the photoelectric effect was ~1.3 μ) was used to determine the time characteristics of single picosecond pulses emitted by an erbium laser at the fundamental frequency (2.94 μ) and at the second harmonic (1.47 μ). The duration of the photoresponse in the case of the fundamental-frequency pulses was 45 psec and the threshold sensitivity of the system was 108 W/cm2. It was found that the photoresponse of the image converter was strongly nonlinear.
Using SWAT to Target Critical Source Sediment and Phosphorus Areas in the Wister Lake Basin, USA (2009)

Problem statement: Wister Lake is located in the San Bois Mountains in southeastern Oklahoma, USA. The reservoir is primarily used as a water supply and flood storage to over 40,000 residents in the area. Due to high levels of phosphorus and sediment, Wister Lake is listed as a high priority basin for the State of Oklahoma. To help address these water quality problems, the Oklahoma Conservation Commission provided cost share funds for landowners in the basin to implement conservation practices. Approach: The objective of this study was to identify or target agricultural land that contributed disproportional pollutant losses, i.e. critical source areas. Results: Implementing conservation practice in these critical source areas allowed optimal placement conservation practices. The Soil and Water Assessment Tool (SWAT) model was used to identify critical source areas of phosphorus and sediment in the Wister Lake basin. SWAT predicted 57,000 metric tons a year of sediment and 84,000 kilograms a year of total phosphorus from upland areas in the basin. Eighty-five percent of the pollutant load originated from just 10% of the basin. Conclusion/Recommendations: This allowed the OCC to identify and contact specific agricultural producers to recruit into their water quality program, which optimized the use of limited cost share funds.