gebhart/patrepeval huggingface dataset:
A rapid high‐precision analytical method for triple oxygen isotope analysis of CO <sub>2</sub> gas using tunable infrared laser direct absorption spectroscopy (2022)

We have successfully developed an analytical technique for the simultaneous determination of the δ<sup>17</sup> O and δ<sup>18</sup> O values of CO<sub>2</sub> gas. The precision is equal to or better than that of existing techniques, with no additional chemical treatments required. Analysis time is rapid, and the system is easily automated so that large numbers of samples can be analyzed with minimal effort.
Efficient data evaluation for thermographic crack detection (2011)

Abstract We present an all-purpose crack detection algorithm for flying spot thermography which is directly applicable to a thermogram sequence without the need of any additional information about the experimental setup. A single image containing distinct crack signatures is derived in two steps. Firstly, the spatial derivative is calculated for each frame of the sequence and, secondly, the resulting data set is sorted pixel wise along the time axis. The feasibility of the proposed procedure is proven by testing a piece of rail that comprises roll contact fatigue cracks and by comparing the results with magnetic particle testing. Keywords: Active thermographylaser scannerrailwayroll contact fatigueopen surface cracks
Abstract 923: Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer (2020)

Abstract KRAS is one of the most commonly identified driver oncogenes in non-small cell lung cancer (NSCLC) and is frequently associated with disease refractory to currently available modalities of treatment. Targeted therapy to inhibit MEK signaling has shown promising tumor growth control in preclinical models, but is followed by quick rebound in tumor growth. Recently, immune checkpoint blockade has demonstrated clinical activity by dis-inhibiting T cells suppressed in the tumor microenvironment. Thus, we sought to identify the most effective therapy for the treatment of KRAS mutant NSCLC patients by targeting cancer cells and activating immune infiltrating cell populations concurrently. To achieve this, we focused on studying the impact of pulsatile MEK inhibition on the immune microenvironment utilizing Kras mutant lung cancer cell lines and Kras mutant transgenic lung cancer mouse models. We found that pulsatile MEK inhibition maintained T cell activation better than continuous treatment ex vivo and in vivo. Treatment with two different MEK inhibitors (selumetinib and trametinib) each resulted in higher CTLA-4 and PD-1 expression in T cells using pulsatile treatment, compared to continuous treatment ex vivo. In addition, the pulsatile schedule showed superior anti-tumor effects and delayed drug resistance compared to continuous administration in vivo. Further, a combination of pulsatile MEK inhibitor treatment and CTLA-4 blockade resulted in the most prolonged survival of Kras tumor-bearing mice. Similar experiments in immune-deficient mice confirmed that this prolonged survival is conferred by adaptive immunity. Our findings set the foundation for a combinatorial therapeutic strategy using pulsatile targeted therapy together with immune checkpoint blockade in patients to optimally enhance tumor apoptosis and promote long-term immune response simultaneously. We are now continuing our studies using a KRAS G12C inhibitor to define its immune modulating properties and will then rationally combine with immune based therapy. Citation Format: Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Lauren Dong, Elliott J. Brea, Sean Houghton, David Redmond, Hong Zhong, Jonathan Boiarsky, Esra A. Akbay, Paul D. Smith, Taha Merghoub, Kwok-Kin Wong, Jedd D. Wolchok. Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 923.
3D Imaging and Its Derivatives in Clinical Research and Practice (2000)

(2000). 3D Imaging and Its Derivatives in Clinical Research and Practice. Critical Reviews in Diagnostic Imaging: Vol. 41, No. 2, pp. 69-156.
Industrial Application of Through-Process Modelling II: Microstructural Models and Descriptors Required for Thermo-Mechanical Processing (2006)

Through-Process modelling (TPM) of microstructure evolution during thermomechanical processing of sheet produced from direct chill (DC) cast non-heat treatable aluminium alloys is discussed. In a companion paper [1] the upstream processes of casting and homogenisation were dealt with, whereas the present paper focuses on the downstream deformation and annealing steps. Some recent advances in relevant model development are reviewed, and the important microstructural descriptors and their interactions are outlined. Together with two application examples – coiling of hot strip, and cold rolling of foil – current knowledge gaps in theory and modelling capability are highlighted.
Line selection and evaluation of radio frequency glow discharge atomic emission spectrometry for the analysis of copper and aluminum alloys (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLine selection and evaluation of radio frequency glow discharge atomic emission spectrometry for the analysis of copper and aluminum alloysTina R. Harville and R. Kenneth. MarcusCite this: Anal. Chem. 1993, 65, 24, 3636–3643Publication Date (Print):December 15, 1993Publication History Published online1 May 2002Published inissue 15 December 1993https://pubs.acs.org/doi/10.1021/ac00072a017https://doi.org/10.1021/ac00072a017research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hanford Tank Farms Waste Certification Flow Loop Test Plan (2010)

A future requirement of Hanford Tank Farm operations will involve transfer of wastes from double shell tanks to the Waste Treatment Plant. As the U.S. Department of Energy contractor for Tank Farm Operations, Washington River Protection Solutions anticipates the need to certify that waste transfers comply with contractual requirements. This test plan describes the approach for evaluating several instruments that have potential to detect the onset of flow stratification and critical suspension velocity. The testing will be conducted in an existing pipe loop in Pacific Northwest National Laboratory’s facility that is being modified to accommodate the testing of instruments over a range of simulated waste properties and flow conditions. The testing phases, test matrix and types of simulants needed and the range of testing conditions required to evaluate the instruments are described
Kriterien und Methoden zur längsdynamischen Führung von FahrzeugkolonnenCriteria and Methods for Longitudinal Guidance of Vehicle Platoons (2009)

Zusammenfassung In diesem Beitrag wird ein Regelkonzept zur längsdynamischen Führung von Fahrzeugkolonnen vorgestellt, das neben Abstandsfehlern die Beschränkung maximaler Geschwindigkeiten und Beschleunigungen der Folgefahrzeuge im Entwurf bewertet. Diese Kriterien werden, neben Robustheitsanforderungen, als lineare Matrixungleichungen formuliert und Regelungen für unterschiedliche Informationsverfügbarkeit optimiert und in Simulationen erprobt.
Enantioselective Desymmetrization via Carbonyl-Directed Catalytic Asymmetric Hydroboration and Suzuki–Miyaura Cross-Coupling (2015)

The rhodium-catalyzed enantioselective desymmetrization of symmetric γ,δ-unsaturated amides via carbonyl-directed catalytic asymmetric hydroboration (directed CAHB) affords chiral secondary organoboronates with up to 98% ee. The chiral γ-borylated products undergo palladium-catalyzed Suzuki-Miyaura cross-coupling via the trifluoroborate salt with stereoretention.
Common Carp Affect Turbidity and Angler Catch Rates of Largemouth Bass in Ponds (1997)

We examined effects of common carp Cyprinus carpio on angler catch rates of largemouth bass Micropterus sahnoides in experimental ponds. Catch rates were significantly lower and turbidity was significantly greater in ponds with common carp. Maximum angler catch rates were negatively correlated with turbidity. Densities of catchable-sized largemouth bass (>200 mm total length) in ponds with and without common carp were not significantly different.
Spin alignment and phase angles in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">C</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>12</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math>+<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">C</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>12</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math>inelastic scattering (1983)

The spin alignment $A$ and the relative phase angle $\ensuremath{\beta}$ between the $m=+2 \mathrm{and} \ensuremath{-}2$ substates populated in $^{12}\mathrm{C}$+$^{12}\mathrm{C}$(${2}_{1}^{+}$) inelastic scattering were measured over a wide range of particle scattering angles ($53\ifmmode^\circ\else\textdegree\fi{}<{\ensuremath{\theta}}_{\mathrm{c}.\mathrm{m}.}<101\ifmmode^\circ\else\textdegree\fi{}$) and interaction energies ($15<{E}_{\mathrm{c}.\mathrm{m}.}<33$ MeV). Although the substate population parameters depend rather strongly on reaction angle, the angle-averaged alignment is markedly enhanced at energies where either broad or narrow maxima occur in $\ensuremath{\sigma}(E)$, at least below ${E}_{\mathrm{c}.\mathrm{m}.}=26$ MeV. Above that energy variations in the alignment become damped with respect to both bombarding energy and reaction angle. The relative phase $\ensuremath{\beta}(\ensuremath{\theta})$ is approximately linear in $\ensuremath{\theta}$ at most energies. For energies below ${E}_{\mathrm{c}.\mathrm{m}.}=26$ MeV corresponding to gross structure maxima in the inelastic cross sections, the measured dependence of the phase on reaction angle suggests that the reaction is dominated at these energies by individual entrance and exit channel partial waves $L$ and ${L}^{\ensuremath{'}}$, respectively, and that these are related by ${L}^{\ensuremath{'}}=L\ensuremath{-}2$. Thus a strongly aligned configuration can be associated with the maxima. At neighboring energies no evidence for such alignment was found. Calculations with the band-crossing, diffraction, distorted-wave Born approximation, and barrier-top models were compared to the measurements. None provide an adequate representation of the data.NUCLEAR REACTIONS $^{12}\mathrm{C}(^{12}\mathrm{C}, ^{12}\mathrm{C}\ensuremath{\gamma})$, ${E}_{\mathrm{lab}}=30\ensuremath{-}65$ MeV, ${\ensuremath{\theta}}_{\mathrm{c}.\mathrm{m}.}(^{12}\mathrm{C})=53\ifmmode^\circ\else\textdegree\fi{}\ensuremath{-}101\ifmmode^\circ\else\textdegree\fi{}$. Measured particle-$\ensuremath{\gamma}$ angular correlations; deduced magnetic substate alignments, phase angles; compared with model predictions.
ChemInform Abstract: ROTIERENDE RING‐SCHEIBEN‐ELEKTRODEN 4. MITT. DIMERISIERUNGS‐ UND ECE‐RK. ZWEITER ORDNUNG (1972)

Abstract Digital‐Simulationsverfahren wurden zur Berechnung der Gleichgewichtsströ‐ me an der rotierenden Ring‐Scheiben‐Elektrode (RSE) als Funktionen eines Geschwindigkeitsparameters verwendet, der eine exakte Abhängigkeit von der Konzentration der Stammsubstanz sowie der Rotationsgeschwindigkeit besitzt.
[Septic shock during the immediate post-partum period revealing a liver abscess in a woman with Crohn's disease]. (1999)

Liver abscess is a rare complication of Crohn's disease. We report one case in a 27 year-old woman, presenting as a sepsis after delivery. Crohn's disease was quiescent at presentation. Pregnancy was the only predisposing condition. An intestinal fistula was diagnosed by ultrasonography. The patient was treated by antibiotics, bowel resection and surgical drainage of the abscess.
Evaluation of NSAIDs for treating post‐endodontic pain (2002)

Although many studies have evaluated analgesic strategies for control of postendodontic pain, there have been no systematic reviews of this literature. This article describes the process for conducting a systematic review and uses this method to analyze the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) for treatment of postendodontic pain.
ChemInform Abstract: STUDIES ON THE REACTIVITY OF METAL‐Π‐COMPLEXES. 25. A GENERALLY APPLICABLE E SYNTHESIS OF SANDWICH TYPE COMPLEXES WITH PALLADIUM‐PALLADIUM OR PLATINUM‐PLATINUM BONDING (1977)

Abstract Die sandwichartigen Pd‐Pd‐Allyl‐Komplexe (II), (IV) und (VI) werden durch äquimolare Umsetzung der Einkernkomplexe (I), (III) bzw. (V) mit Bis‐[tert.‐phosphin]‐Pd‐Komplexen dargestellt.
Out-of-sequence measurement processing for tracking ground target using particle filters (2003)

We present a filtering algorithm for processing out-of-sequence measurements (OOSMs) in multi-sensor target tracking using the particle filter (PF). Measurements can arrive out-of-sequence at a fusion center due to varying data pre-processing times at the sensor platforms and communication delays in a multi-sensor target tracking system. Standard filtering algorithms such as the Kalman filter (KF), extended KF (EKF), interacting multiple model (IMM) filter, and PF cannot be directly applied to process the OOSM. Processing of the OOSM requires new algorithms within the framework of KF, EKF, IMM, or PF. The ground moving target indicator (GMTI) radar sensors play an important role in the military and commercial domain such as surveillance of ground moving targets and air traffic control. The GMTI measurement model is a nonlinear function of the target state. Therefore, extension of the existing linear OOSM filtering algorithms to the GMTI filtering problem with OOSMs would require EKF type linearization and hence would be sub-optimal. As a superior alternative to the EKF, the PF has been successfully applied to a number of nonlinear filtering problems where the EKF or IMM using EKF is sub-optimal. Our OOSM PF algorithm does not require a large amount of storage and preliminary results based on numerical simulations show that the algorithm yields results comparable to previous algorithms.
(±)-<i>N</i>-[4-Acetyl-5-methyl-5-(4-methylcyclohex-3-enyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]acetamide (2008)

The new title thiadiazole compound, C(14)H(21)N(3)O(2)S, was semi-synthesized starting from 1-(4-methyl-cyclo-hex-3-en-yl)ethanone, a natural product isolated from Cedrus atlantica essential oil. The stereochemistry has been confirmed by single-crystal X-ray diffraction. The thia-diazo-line ring is roughly planar, although it may be regarded as having a half-chair conformation. The cyclo-hexenyl ring has a half-chair conformation. The most inter-esting feature is the formation of a pseudo-ring formed by four mol-ecules associated through N-H⋯O hydrogen bonds around a fourfold inversion axis, forming an R(4) (4)(28) motif.
Three-Dimensional Magnetic Resonance Imaging for Guiding Tibial and Femoral Tunnel Position in Anterior Cruciate Ligament Reconstruction: A Cadaveric Study (2020)

Background: Femoral and tibial tunnel malposition for anterior cruciate ligament (ACL) reconstruction (ACLR) is correlated with higher failure rate. Regardless of the surgical technique used to create ACL tunnels, significant mismatches between the native and reconstructed footprints exist. Purpose: To compare the position of tunnels created by a standard technique with the ones created based on preoperative 3-dimensional magnetic resonance imaging (3D MRI) measurements of the ACL anatomic footprint. Study Design: Controlled laboratory study. Methods: Using 3D MRI, the native ACL footprints were identified. Tunnels were created on 16 knees (8 cadavers) arthroscopically. On one knee of a matched pair, the tunnels were created based on 3D MRI measurements that were provided to the surgeon (roadmapped technique), while on the contralateral knee, the tunnels were created based on a standard anatomic ACLR technique. The technique was randomly assigned per set of knees. Postoperatively, the positions of the tunnels were measured using 3D MRI. Results: On the tibial side, the median distance between the center of the native and reconstructed ACL footprints in relation to the root of the anterior horn of the lateral meniscus medially was 1.7 ± 2.2 mm and 1.9 ± 2.8 mm for the standard and roadmapped techniques, respectively ( P = .442), while the median anteroposterior distance was 3.4 ± 2.4 mm and 2.5 ± 2.5 mm for the standard and roadmapped techniques, respectively ( P = .161). On the femoral side, the median distance in relation to the apex of the deep cartilage (ADC) distally was 0.9 ± 2.8 mm and 1.3 ± 2.1 mm for the standard and roadmapped techniques, respectively ( P = .195), while the median distance anteriorly from the ADC was 1.2 ± 1.3 mm and 4.6 ± 4.5 mm for the standard and roadmapped techniques, respectively ( P = .007). Conclusion: Providing precise radiological measurements of the ACL footprints does not improve the surgeon’s ability to position the tunnels. Future studies should continue to attempt to provide tools to improve the tunnel position in ACLR. Clinical Relevance: This cadaveric study indicates that despite the use of 3D MRI in understanding the ACL anatomy, re-creating the native ACL footprints remains a challenge.
Supplementary Figure 1 from Nm23-H1 Indirectly Promotes the Survival of Acute Myeloid Leukemia Blast Cells by Binding to More Mature Components of the Leukemic Clone (2023)

Supplementary Figure 1 from Nm23-H1 Indirectly Promotes the Survival of Acute Myeloid Leukemia Blast Cells by Binding to More Mature Components of the Leukemic Clone
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel (1992)

Voltage-sensitive sodium channels are responsible for the initiation and propagation of the action potential and therefore are important for neuronal excitability. Complementary DNA clones encoding the beta 1 subunit of the rat brain sodium channel were isolated by a combination of polymerase chain reaction and library screening techniques. The deduced primary structure indicates that the beta 1 subunit is a 22,851-dalton protein that contains a single putative transmembrane domain and four potential extracellular N-linked glycosylation sites, consistent with biochemical data. Northern blot analysis reveals a 1,400-nucleotide messenger RNA in rat brain, heart, skeletal muscle, and spinal cord. Coexpression of beta 1 subunits with alpha subunits increases the size of the peak sodium current, accelerates its inactivation, and shifts the voltage dependence of inactivation to more negative membrane potentials. These results indicate that the beta 1 subunit is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the rat brain sodium channel.
Mucin biosynthesis revisited. The enzymatic transfer of Gal in beta 1,3 linkage to the GalNAc moiety of the core structure R1-GlcNAc beta 1,6GalNAc alpha-O-R2. (1992)

Synthetic glycosides containing the core, -Glc-NAc beta 1,6GalNAc alpha-, acted as acceptors for beta-galactosyltransferase of human ovarian tumor. A significant amount of Gal was transferred from UDP-Gal (100 nmol) to the alpha-benzylglycoside of LacNAc beta 1,6GalNAc (LGBn) (25.1 nmol of Gal) and the alpha-ortho-nitrophenylglycosides of LacNAc beta 1,6GalNAc (22.0 nmol of Gal), GlcNAc beta 1,6GalNAc (15.5 nmol of Gal), and Fuc alpha 1,3GlcNAc beta 1,6GalNAc (25.9 nmol of Gal); LacNAc beta 1,6(Gal beta 1,3)GalNAc alpha-O-Bn (where Bn is benzyl) was almost inactive (only 1.2 nmol of Gal), indicating the Gal transfer to the alpha-GalNAc moiety. The product from LGBn was isolated in microgram quantities and identified by fast atom bombardment mass spectrometry as LacNAc beta 1,6(Gal beta 1,3)GalNAc alpha-O-Bn. The alpha GalNAc:beta 1,3Gal transferase was present in high concentration in ovarian tumor tissue (ovarian cancer serum----1.4; ascitic fluid----0.9; tumor----17.4). Asialo Cowper's gland mucin (ACGM) at 5 mg/ml reaction mixture inhibited the transfer of Gal to LGBn (25.2 and 53.4% respectively for 2 and 18 h incubation at 37 degrees C); inhibition by LGBn was 13.4 and 24.5%, respectively. In contrast to the inhibition by ACGM (25.2-31.6%), there was substantial increase (13.4-35.7%) in the inhibition by LGBn, when the incubation for 2 h at 37 degrees C was continued for 40 h at 4 degrees C, indicating the high affinity of LGBn for the enzyme at lower temp. Km for LGBn in presence of ACGM was 7.6 mM and in absence, 2.7 mM; Km for ACGM (M(r) 200,000) in presence of LGBn was 16.1 microM and Ki for ACGM (as the inhibitor) was 41.7 microM. In comparison with two normal ovarian tissues, the enzyme was found to be low (55-67%) in three ovarian tumors and high (146-260%) in two ovarian and one uterus tumors, as measured with ACGM; the synthetic acceptors showed similar activities. The enzyme had nearly the same extent of activity in the pH range 6-8. Fuc alpha 1,3GlcNAc beta 1,6GalNAc alpha-O-ONP had the highest affinity for the enzyme. The present study demonstrates the feasibility of beta 1,3Gal attachment on alpha GalNAc, which has already been substituted by beta 1,6GlcNAc, then elongated by beta 1,4Gal and also terminated by alpha 1,3Fuc.