gebhart/patrepeval huggingface dataset:
Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression (2019)

Our results demonstrated that Grem1 is a pivotal factor in the reciprocal interplay between breast cancer cells and CAFs, which promotes cancer cell invasion. Targeting Grem1 could be beneficial in the treatment of breast cancer patients with high Grem1 expression.
Effect of Andrographolide on Monkey Hepatocytes against Galactosamine Induced Cell Toxicity : An In-Vitro Study (2007)

Andrographolide, the active constituent, isolated from the plant Andrographis paniculata showed concentration dependent (1-100 microg/mL) activity against galactosamine (GALN 400 microg/mL) induced acute injury in isolated monkey hepatocytes, following 48 hours of the incubation at 370 C. The effect of andrographolide was measured on viability (trypan blue exclusion and oxygen uptake tests), biochemical marker enzymes - aspartate amino transaminase (AST), alanine amino transaminase (ALT) and alkaline phosphatase (AlP) and bile contents (bile salts and bile acids). It significantly increased the percent viability of cells and was capable of preserving 90-100% cell integrity. The cellular leakage of enzymes and bile contents following incubation with GALN was significantly modulated by andrographolide treatment. Its activity was found superior to that of silymarin, a standard hepatoprotective compound, tested simultaneously for comparison. The findings also emphasize the possible use of an in-vitro primary cell culture system as an alternative to in-vivo, in the early stage of drug discovery.
Blacklegged Tick or Deer Tick, Ixodes scapularis Say (Arachnida: Acari: Ixodidae) (1969)

In the United States, the blacklegged tick, Ixodes scapularis Say affects the greatest number of people for threeprincipal reasons: their geographic distribution coincides in the northeastern United States with the greatest concentration of humans (Miller et al. 1990); spirochete infection rates are high, often exceeding 25 (Burgdorfer et al. 1982, Anderson et al. 1983, Magnarelli et al. 1986); and the geographical range of the tick is spreading (Lastavica et al. 1989, Anderson et al. 1990, Godsey et al. 1987, Davis et al. 1984). This document is EENY-143, one of a series of Featured Creatures from the Entomology and Nematology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published: July 2000. Revised: June 2003. EENY-143/IN300: Blacklegged Tick or Deer Tick, Ixodes scapularis Say (Arachnida: Acari: Ixodidae) (ufl.edu)
[The influenza season 2004/'05 in the Netherlands with the largest epidemic of the last 5 years caused by the virus variant A/California and the composition of the vaccine for the season 2005/'06]. (2005)

In the Netherlands, the influenza epidemic of the 2004/'05 season started late. The background value of 3 cases of an influenza-like illness per 10,000 inhabitants per week was exceeded from week 1 until week 14 of 2005. The magnitude of the epidemic was the largest of the last 5 years, namely 104 per 10,000 inhabitants. As usual, the epidemic was caused mainly by influenza-A viruses of subtype H3N2 and to a lesser degree by A/H1N1 and B viruses. The H3N2-virus isolates belonged to the newly emerged variant A/California/7/04, which deviated slightly from the vaccine strain used for the 2004/'05 season. The influenza-B and H1N1 viruses matched the corresponding vaccine viruses well. For the 2005/'06 season, the World Health Organization has recommended the following vaccine composition: A/California/7/04 (H3N2), A/New Caledonia/20/99 (HiNI), and B/Shanghai/361/02.
Innovations in the surgical treatment of gliomas (2013)

Gliomas are common brain tumors that have historically carried a dire prognosis with few useful treatment options. However, modern neurosurgical literature supports a strong role for aggressive surgical resection in some cases. Technical advances in neuroimaging and neuronavigation have changed the way surgeons approach these tumors, and intraoperative technology aimed at improving extent of resection without compromising safety has led to improved long-term results. Here, the authors review the state-of-the-art surgical approach to this challenging disease.
Point to point label switching protocol for optical access networks (2002)

This paper concentrates on the provisioning of services using point-to-point protocol (PPP) and label switching scheme in IP over dense wavelength division multiplexing (DWDM) access networks. For the reason of usefulness of the PPP and the efficiency of the label switching technique in access networks, the authors propose three solutions for end-to-end or end-to-provider communication on the optical access networks. Three solution candidates for access networks are 10 Gigabit Ethernet network, resilient packet ring (RPR) network, and passive optical network (PON). These topologies have their own advantages. The article shows how to use these architectures properly in the access networks with the PPP and label switching techniques over a DWDM layer.
Lewis Acid-Promoted Addition of 1,3-Bis(silyl)propenes to Aldehydes: A Route to 1,3-Dienes (2011)

The Lewis acid-promoted addition of 1,3-bis(silyl)propenes to aldehydes to provide the corresponding (E)-1,3-dienes in excellent stereoselectivity and good to excellent yields is reported. The procedure is mild, base-free, and operationally straightforward.
Strain rate dependence of the growth rate of grain boundary cavities during the high cycle high temperature fatigue of copper (1999)

High temperature fully reversed fatigue tests of high purity copper were made as a function of stress amplitude. A mean cavity volume V{sub p} and corresponding number density of cavities N{sub p} were determined from the total cavity volume fraction V{sub v} obtained from precision density measurements (PDM) and the total cavity surface area S{sub v} calculated from small angle neutron scattering (SANS) measurements. Under the range of stress amplitudes tested, the plastic strain rate d{epsilon}{sub p}/dt was found to cover three orders of magnitude. The results of these tests of the influence of stress amplitude on cavity growth were combined with previous results in which the frequency of cycling was varied. It was found that the cavity growth rate correlates well with the measured plastic strain and stress amplitude through the relation dV{sub p}/dt {proportional{underscore}to} (d{epsilon}{sub p}/dt){sup 0.45} {proportional{underscore}to} {Delta}{sigma}{sup 2}.
Functional Outcome of Patients With Rotationplasty About the Knee (2003)

Rotationplasty is a surgical procedure designed to achieve a durable reconstruction after the resection of tumors about the knee. However, because of the recent advances with expandable prostheses, rotationplasty has been less popular in the skeletally immature patient, particularly in the United States. We assessed the functional outcome of patients who had rotationplasty to allow better comparison with other operative techniques in this patient population. Seven patients, who were operated on at our institution at an average age of 9.4 years (range, 5-14 years), had a followup of at least 4 years and were evaluated in the Motion Analysis Laboratory. The gait analysis included kinetic, kinematic and temporal-distance parameters to evaluate the patient's functional performance. The data also were compared with measurements of a population of 25 able-bodied subjects and with four subjects with distal above-knee amputation. All patients had the ability to weightbear fully. All patients ambulated without assistive devices. Gait analysis of patients with rotationplasty revealed only slight asymmetry regarding stride duration, stride length, cadence, velocity and stance-swing ratio compared with healthy subjects. Although the gait was similar to subjects with distal above-knee amputation, knee motion was superior in patients who had rotationplasty. Rotationplasty offers a durable reconstruction. Rotationplasty allows the patient to actively control the knee, which results in a coordinated gait pattern, which is similar to the gait of the able-bodied population, and better than in subjects with distal-knee amputation.
I.amAble: aprendizaje e inclusión educativa mediante talleres científicos (2020)

I.amAble ha ofrecido a estudiantes universitarios de fisica, quimica, veterinaria, biologia y educacion la oportunidad de complementar su formacion mediante el diseno, la realizacion y la evaluacion de talleres cientificos que faciliten la inclusion de personas con diversidad cognitiva.
Los talleres han sido disenados por el alumnado universitario de ciencias y perfilados por estudiantes de educacion para ser llevados a cabo por alumnado preuniversitario en parejas, de forma que un miembro pertenezca a un centro de secundaria ordinario y el otro miembro a un centro de educacion especial. Aquellos talleres que se han considerado mas adecuados por su adaptabilidad se han llevado a la practica guiados por estudiantes de ciencias y de educacion.
Los miembros del proyecto, que incluyen representantes de todos los estamentos universitarios, han supervisado todas las tareas descritas anteriormente. Ademas de los miembros de la Universidad Complutense, tambien figuran personas voluntarias de otras instituciones cientificas y educativas.
El alumnado universitario ha tenido la posibilidad, no solo de asentar y profundizar algunos contenidos cientificos o poner en practica algunas de las ensenanzas adquiridas, sino tambien de desarrollar su empatia, su capacidad de comunicar e improvisar y de adaptarse a un publico heterogeneo. Ello ha mejorado sus perspectivas laborales, especialmente dentro de la educacion formal e informal (animacion sociocultural, museos cientificos...). Ademas, han contribuido a facilitar la inclusion educativa de las personas con diversidad funcional y a mejorar la cultura cientifica de la sociedad.
Con este proyecto, inspirado en la metodologia Aprendizaje-Servicio (ApS), se ha pretendido tambien mejorar la accesibilidad a las experiencias y contenidos cientificos y facilitar la inclusion educativa de las personas con diversidad funcional, especialmente diversidad cognitiva o intelectual.
En la primera edicion de I.amAble (2016-17) se hizo hincapie en el diseno y seleccion de fichas para hacer talleres (aunque tambien se realizaron talleres). En la segunda edicion (2017-18) se puso un mayor enfasis en llevar los talleres a un mayor numero de centros educativos. En la pasada edicion (2018-19) se puso el acento en los procesos de evaluacion. En esta cuarta edicion (2019-20), se han seguido trabajando y puliendo todos esos aspectos, pero se ha priorizado la transformacion de I.amAble en un proyecto de tipo aprendizaje-servicio, integrandolo en asignaturas formales, concretamente en Complementos de Fisica y Complementos de Quimica, del Master en Formacion de Profesorado, en la especialidad de Fisica y Quimica.
Streptococcus hyovaginalis sp. nov. and Streptococcus thoraltensis sp. nov., from the Genital Tract of Sows (1997)

Two groups of strains isolated from sows were shown to belong to new sublines in the genus Streptococcus. Based on phenotypic and phylogenetic analyses, we propose that these bacteria should be classified as two new species, Streptococcus hyovaginalis sp. nov. and Streptococcus thoraltensis sp. nov. These two species are found in the genital tract, but the capnophilic species S. thoraltensis may also occur in the intestinal tract of pigs. The type strain of S. hyovaginalis is SHV515 (= LMG 14710), and S69 (= LMG 13593) is the type strain of S. thoraltensis.
Biochemical Properties of the Ovarian Granulosa Cell Type 2-Angiotensin II Receptor* (1991)

Angiotensin II (Ang II) receptors, estimated by the specific binding of the peptide Ang II receptor antagonist [125I] [Sar1,Ile8]Ang II, are localized on multiple ovarian structures, including follicular granulosa cells. Using the Ang II receptor subtype-selective nonpeptide antagonists, DuP 753 [selective for the type 1 Ang II (AT1) receptor] and PD 123319 [selective for the type 2 Ang II (AT2) receptor], we show that follicular granulosa cells, in vivo and in vitro, exclusively express the AT2 receptor. To understand the function of Ang II in ovarian follicles, we compared the biochemical properties and transmembrane signaling pathways of the granulosa cell AT2 receptor with those properties generally associated with Ang II receptors found in the adrenal zona glomerulosa, where the AT1 receptor predominates. The mol wt of the granulosa cell AT2 receptor (approximately 79,000), estimated by affinity cross-linking studies, is similar to that of the adrenal zona glomerulosa Ang II receptor. Like the adrenal zona glomerulosa Ang II receptor, binding inhibition studies show that the granulosa cell AT2 receptor binds Ang II and Ang III with high affinity (IC50, approximately 0.5 nM for both peptides), but not Ang-(1-7) (IC50, approximately 0.5 microM) or Ang-(1-5) (IC50, greater than 10 microM). However, unlike the adrenal zona glomerulosa Ang II receptor, the granulosa cell AT2 receptor does not undergo agonist-induced endocytosis. Further, Ang II does not affect basal or stimulated inositol phosphate production, intracellular Ca2+ mobilization, or adenylyl cyclase or guanylyl cyclase activity in granulosa cells. The granulosa cell AT2 receptor does not appear to directly interact with guanine nucleotide binding regulatory proteins, since agonist dissociation from the AT2 receptor is unaffected by the GTP analog guanosine 5'-O-(3-thiotriphosphate); in contrast, the AT1 receptor appears to directly interact with guanine nucleotide binding regulatory protein, because agonist dissociation from the AT1 receptor is stimulated by guanosine 5'-O-(3-thiotriphosphate). These studies clearly demonstrate that the granulosa cell AT2 receptor is functionally distinct from the well characterized adrenal zona glomerulosa Ang II receptor. The exclusive presence of the AT2 receptor on the granulosa cell makes it an ideal cell type for studying the potential, but as yet unknown, function of this receptor.
Evidence for generation of O2- or an O2--like factor in the decomposition of linoleic acid hydroperoxide. (1979)

oxygen (1O2), the superoxide anion (O2-)
Synthesis and Characterization of Polyoxometalates For Energy Storage Applications. (2011)

Abstract not provided.
Broadening of carbonyl stretching vibration bands appearing for acrylate copolymers (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBroadening of carbonyl stretching vibration bands appearing for acrylate copolymersFumio Kamiyama, Hisayuki Matsuda, and Hiroshi InagakiCite this: J. Phys. Chem. 1967, 71, 12, 4153–4154Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/j100871a078https://doi.org/10.1021/j100871a078research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Properties of Strong Caustic Soda Solutions (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of Strong Caustic Soda SolutionsF. C. Standiford and W. L. BadgerCite this: Ind. Eng. Chem. 1954, 46, 11, 2400–2403Publication Date (Print):November 1, 1954Publication History Published online1 May 2002Published inissue 1 November 1954https://pubs.acs.org/doi/10.1021/ie50539a051https://doi.org/10.1021/ie50539a051research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Health Aware Planning Under Uncertainty for Collaborating Heterogeneous Teams of Mobile Agents (2015)

We consider the problem of solving hybrid discrete-continuous Markov Decision Processes (MDPs) that are often encountered in computing optimal policies for complex multi-agent missions with both continuous vehicle dynamics and discrete mission-state transition models, in the presence of potential health degradations and failures of individual agents. A comprehensive Health Aware Planning (HAP) framework is proposed that establishes a feedback between mission planning and vehicle-level learning-focused adaptive controllers through online learned own models of agent health and capabilities. The HAP framework accounts for predicted likelihood of vehicle health degradations captured through probabilistic state-dependent models that are integrated into the MDP formulation. This proactive ability to anticipate health degradation and plan accordingly enables the HAP approach to consistently outperform planners that change the policies only after failures have occurred (reactive planners). The approach is tested on a large-scale (≈ 10 10 state–action pairs) long-duration (persistent) target tracking scenario using a novel on-trajectory planning algorithm, and demonstrated to sustain higher mission performance by reducing the number of failures and re-assessing Unmanned Aerial Vehicle (UAV) capabilities.
Magnetic cannon: The physics of the Gauss rifle (2017)

The magnetic cannon is a simple device that converts magnetic energy into kinetic energy. When a steel ball with low initial velocity impacts a chain consisting of a followed by addition steel balls, the last ball in the chain gets ejected at a much larger velocity. The analysis of this spectacular device involves an understanding of advanced magnetostatics, energy conversion, and the collision of solids. In this article, the phenomena at each step of the process are modeled to predict the final kinetic energy of the ejected ball as a function of a few parameters that can be experimentally
Protein–carbohydrate interactions: At the heart of biochemistry (2006)

Proteins that possess the ability to bind carbohydrates specifically and reversibly abound in nature, being present in all living organisms, from viruses to humans. Their interactions with their ligands are the basis of a myriad of biological processes, both normal and pathological1–3 (Table 1). The high selectivity required for these interactions is provided by a specific stereochemical fit between complementary molecules, the protein on the one hand and the carbohydrate on the other. This concept has its origins in the lock-and-key hypothesis, introduced by Emil Fischer at the end of the 19th Century to explain the specificity of interactions between enzymes (he studied glycosidases) and their substrates (carbohydrates), i.e. between molecules in solution. In time it was extended to describe the interactions of cells with soluble molecules and with other cells.
A Computer Simulation of the Branching Structure Formation Using a Flow System Model. (2003)

In this paper, we propose a model of the flow system and consider its formation and validity of the branching structure which is frequently observed in the flow system. To evaluate our model, we use the simulation program which executes formation of the branching structure in the flow system. Here, we define the flow system as a system which transports or transmits a stream of materials, energy and information in the system et al. The flow system is often seen in the natural world and the man-made social system. By analyzing the natural flow systems, it is expected that many useful principles for a design of the man-made flow systems could be obtained. For example, by adaptation to environment through a long term process of evolution, trees, as the flow system of creatures seen in the natural world, seem to have an ideal economical form for low consumption of resources. Hence, we attempt to construct the flow system model by referring to the tree form, and considering optimization and adaptation to environment. Simulation results show that low consumption of cost and efficient absorption of energy are realized by the branching structure.
Past, present, and future of endovascular stroke therapies (2012)

Endovascular therapy in the acute management of ischemic stroke has become more common with technologic advances, such as easier navigation into the intracranial circulation and improved treatment efficacy with the advent of revascularization devices. This select review outlines milestones in the application of endovascular therapy in acute ischemic stroke (AIS) and offers some insight into important factors influencing the future directions of endovascular AIS treatment. In particular, we discuss the evolution of endovascular devices for AIS and how ingenuity continues to offer novel treatments. With these advances, the future of endovascular AIS treatment is promising.
Conversion of D-glucose to 5-keto-6-deoxy-D-arabohexose, a component of hygromycin A, by Streptomyces hygroscopicus (1960)

Abstract not available
ChemInform Abstract: Organocatalysis with Dendrimers (2012)

Abstract Review: 64 refs.