gebhart/patrepeval huggingface dataset:
The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells (2013)

Satellite cells are the resident stem cells of skeletal muscle. Mitotically quiescent in mature muscle, they can be activated to proliferate and generate myoblasts to supply further myonuclei to hypertrophying or regenerating muscle fibres, or self-renew to maintain the resident stem cell pool. Here, we identify the transcriptional co-factor Yap as a novel regulator of satellite cell fate decisions. Yap expression increases during satellite cell activation and Yap remains highly expressed until after the differentiation versus self-renewal decision is made. Constitutive expression of Yap maintains Pax7+ and MyoD+ satellite cells and satellite cell-derived myoblasts, promotes proliferation but prevents differentiation. In contrast, Yap knockdown reduces the proliferation of satellite cell-derived myoblasts by ≈40%. Consistent with the cellular phenotype, microarrays show that Yap increases expression of genes associated with Yap inhibition, the cell cycle, ribosome biogenesis and that it represses several genes associated with angiotensin signalling. We also identify known regulators of satellite cell function such as BMP4, CD34 and Myf6 (Mrf4) as genes whose expression is dependent on Yap activity. Finally, we confirm in myoblasts that Yap binds to Tead transcription factors and co-activates MCAT elements which are enriched in the proximal promoters of Yap-responsive genes.
Adenosine Stress 64- and 256-Row Detector Computed Tomography Angiography and Perfusion Imaging (2009)

The combination of CTA and CTP can detect atherosclerosis causing perfusion abnormalities when compared with the combination of quantitative coronary angiography and SPECT.
Using Intelligent System Approaches for Simulation of Electricity Markets (2006)

Significances and approaches of applying intelligent systems to artificial electricity market is discussed. In recent years, with the moving into restructuring of electric system in Japan, the deregulation for the electric market is progressing. The most major change of the market is a founding of JEPX (Japan Electric Power eXchange.) which is expected to help lower power bills through effective use of surplus electricity. The electricity market designates exchange of electric power between electric power suppliers (supplier agents) themselves. In the market, the goal of each supplier agents is to maximize its revenue for the entire trading period, and shows complex behavior, which can model by a multiagent platform. Using the multiagent simulations which have been studied as “artificial market" helps to predict the spot prices, to plan investments, and to discuss the rules of market. Moreover, intelligent system approaches provide for constructing more reasonable policies of each agents. This article, first, makes a brief summary of the electricity market in Japan and the studies of artificial markets. Then, a survey of tipical studies of artificial electricity market is listed. Through these topics, the future vision is presented for the studies.
Synthesis of 1,4-dihydro-1,4-dimethyl-1,4-epoxynaphthalene and conversion to 1,4-dimethyl-1,2,3,4-tetrahydronaphthalene and o-diacetylbenzene (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 1,4-dihydro-1,4-dimethyl-1,4-epoxynaphthalene and conversion to 1,4-dimethyl-1,2,3,4-tetrahydronaphthalene and o-diacetylbenzeneMelvin S. Newman, Hemalata M. Dali, and William M. HungCite this: J. Org. Chem. 1975, 40, 2, 262–264Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/jo00890a029https://doi.org/10.1021/jo00890a029research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators. (1991)

The results demonstrate that, in patients in whom thrombolytic therapy fails to induce reperfusion, the presence of coronary collateral vessels at the onset of myocardial infarction is associated with limitation of infarct size as assessed enzymatically and with improved ventricular function on discharge as assessed by LVEF.
Cobalt-mediated cyclotrimerization and cycloisomerization reactions. Synthetic applications (1999)

This article reviews our contribution in the field of the cobalt(I)-mediated cycliza- tions. The use of new unsaturated partners such as allenes extend the scope and the utility of the previously developed intramolecular (2a2a2) cyclotrimerization. The presence of chiral auxiliaries induced high level of diastereoselectivity in the enediynes cyclization. The discovery of cobalt(I) catalyzed ene-type reaction allows to propose an efficient route to the basic skeleton of tetracyclic diterpenes via a one-pot sequence of cyclizations: (ene-type)/ (2a2a2)/(4a2). This cascade created six carbon-carbon bonds, four rings in a totally stereoselective manner. Finally, a new strategy to the taxoids is proposed.
Crystal Structure of N-[(6-Methoxy-4-oxo-1,4-dihydroquinolin-3-yl)methyl]-2,2-dimethylpropanamide (2004)

The crystal structure of N-[(6-methoxy-4-oxo-1,4-dihydroquinolin-3-yl)methyl]-2,2-dimethylpropanamide (2) was determined by X-ray diffraction analysis. The compound crystallized in the triclinic system, space group P1, with cell parameters of a = 7.829(3)Å, b = 8.995(4)Å, c = 10.646(5)Å, α = 85.86(2)°, β = 86.99(1)°, γ = 88.00(2)°, and Z = 2. The structure was refined by full-matrix least-squares to final values of R1 = 0.049 and wR2 = 0.103. The intermolecular hydrogen bonds of the type N-H…O were observed in the structure.
Neoplastic Conversion and Chromosomal Characteristics of Rat Embryo Cells <italic>In Vitro</italic> (1970)

ALB/N rat-embryo cells, presumably free of murine leukemia virus and grown in a chemically defined medium (CDM) supplemented with serum, underwent “spontaneous” neoplastic conversions in vitro. Cell lines in CDM with horse serum (HS) supplement converted after 9-30 months in vitro, a period significantly longer than that reported for mouse embryo cells in this type medium. From the same embryo cell pool, 1 of 2 lines on CDM with fetal calf serum supplement underwent neoplastic conversion as compared with 3 of 3 lines on HS medium within a period of 412 days, and the cells grown in HS medium produced tumors with shorter latent periods. Cells derived from frozen-thawed cultures converted earlier than those not frozen. Tumor production from the tissue culture cells tended to vary directly with period of culture in vitro. Cells grown on un-supplemented CDM did not convert during the same period (11–38 months) in which the more rapidly dividing lines in serum-supplemented medium did. Cells in HS medium carried with limited or no subculturing, which continued to grow as dense, multilayered cell sheets, did not convert. In the subcultured lines, after an initial period of karyotypic stability (61–110 days), extensive chromosomal alterations occurred. We found no chromosomal alteration or pattern of chromosome change that could be correlated with the neoplastic conversion of the cells.
Comparison of sorting algorithms to increase the range of Hartmann-Shack aberrometry (2010)

Recently many software-based approaches have been suggested for improving the range and accuracy of Hartmann-Shack aberrometry. We compare the performance of four representative algorithms, with a focus on aberrometry for the human eye. Algorithms vary in complexity from the simplistic traditional approach to iterative spline extrapolation based on prior spot measurements. Range is assessed for a variety of aberration types in isolation using computer modeling, and also for complex wavefront shapes using a real adaptive optics system. The effects of common sources of error for ocular wavefront sensing are explored. The results show that the simplest possible iterative algorithm produces comparable range and robustness compared to the more complicated algorithms, while keeping processing time minimal to afford real-time analysis.
Headspace Solid-Phase Microextraction Analysis of Volatiles in Floral Organs of Nelumbo nucifera (2016)

The objective of this study was to identify the main floral scents and their relative contents in the floral organ of Nelumbo nucifera. N. nucifera flower, a traditional Chinese medicinal herb, is rich in volatile compounds. In this study, the volatile components of N. nucifera flowers were investigated by headspace solid-phase microextraction gas chromatography-mass spectrometry for each organ of the flower: petals, sepals, pistils, and stamens. In total, we identified 39 compounds, among which aliphatics were major constituents, representing more than 94% of petals and sepals volatiles, followed by sesquiterpenes representing more than 69% of pistils and stamens volatiles. Pentadecane, 1-pentadecene, 8-hexadecyne, 8-heptadecene, and β-caryophyllene characterize the scent of the N. nucifera flower. We identified 24 volatiles in petals and sepals, 25 volatiles in pistils, and 18 volatiles in stamens. Among the monoterpenes, 3-Isopropylidene-4-methylcyclohexene, isoterpinolene, p-Menth-2-en-7-ol, and methyl 2,6,6- trimethylcyclohex-1-enecarboxylate were analyzed and identified for the first time from the N. nucifera flower. This study demonstrates that N. nucifera flowers differ greatly in volatile composition depending on the floral organ of the plant.
[Embolism caused by cholesterol]. (1991)

Les Embolies de Cholesterol (EC) constituent une entite anatomo-clinique ubiquitaire au carrefour de l'Angiologie, de la Medecine Interne et des Specialites (21). Depuis les premieres descriptions cliniques par Panum en 1862 (17) et histologiques en 1945 par Flory (12), les embolies de cholesterol s'inscrivent comme une complication possiblement grave de la plaque d'atherosclerose
Merged photonic crystal slot waveguide: confining slow modes in tiny volumes (2014)

In this proceeding we are describing the optimization of a silicon slot waveguide coated with titanium dioxide deposited by Atomic Layer Deposition. In addition we show the characterization of a photonic crystal cavity directly patterned on a slot waveguide.
Simulation des régimes cinétiques au moyen de circuits électriques. Détermination des modèles réactionnels. (1980)

National audience
The cell adhesion molecule Echinoid defines a new pathway that antagonizes the <i>Drosophila</i> EGF receptor signaling pathway (2001)

Photoreceptor and cone cells in the Drosophila eye are recruited following activation of the epidermal growth factor receptor (EGFR) pathway. We have identified echinoid (ed) as a novel putative cell adhesion molecule that negatively regulates EGFR signaling. The ed mutant phenotype is associated with extra photoreceptor and cone cells. Conversely, ectopic expression of ed in the eye leads to a reduction in the number of photoreceptor cells. ed expression is independent of EGFR signaling and ED is localized to the plasma membrane of every cells throughout the eye disc. We present evidence that ed acts nonautonomously to generate extra R7 cells by a mechanism that is sina-independent but upstream of Tramtrack (TTK88). Together, our results support a model whereby ED defines an independent pathway that antagonizes EGFR signaling by regulating the activity, but not the level, of the TTK88 transcriptional repressor.
Schlafen 11 Assessment in High-Grade Serous Ovarian Carcinoma: Phenotypic and Histological Distribution (2018)

Objective: To develop a protocol for immunohistochemistry (IHC) to determine the Schlafen 11 (SLFN11) expression in formalin-fixed, paraffin-embedded (FFPE) high-grade serous ovarian carcinoma (HGSOC) samples. Study Design: We validated a reliable SLFN11 antibody (SLFN11-Ab) in IHC choosing between 2 antiSLFN11-Abs used for western blot through the development of a SLFN11-IHC protocol in culture cell block (CCB) of ovarian carcinoma and in an HGSOC tissue microarray (TMA) series. We applied our protocol to a case series of HGSOC samples to confirm our preliminary results. For each case we evaluated both the intensity score (IS) and the distribution score (DS). A final histological score (HS) was obtained as follows: HS=IS×DS. Results: In CCB and TMA series, the antibody #1 at 1:100 dilution was more reliable. This last one was used in our case series to confirm our IHC protocol. DS showed the following results: 27 cases were no stain, 11 cases showed staining for SLFN11 in <10% of cells, 16 cases showed staining in 10–40% of cells, and the remaining 15 cases showed stain in >40% of cells. IS showed the following results: 25 cases were no stain, in 19 cases a dominant weak stain, in 14 cases a moderate stain, and in 11 cases a strong stain. HS for SLFN11 expression presents a normal distribution with a prevalent (≈60%) intermediate expression. Conclusion: We develop a reproducible and standardized IHC protocol to determinate the SLFN11 expression in FFPE HGSOC samples using a modified western blot anti-SLFN11-Ab.
Proton Assisted Recoupling at High Spinning Frequencies (2009)

We demonstrate the successful application of (13)C-(13)C proton assisted recoupling (PAR) on [U-(13)C,(15)N] N-f-MLF-OH and [U-(13)C,(15)N] protein GB1 at high magic angle spinning (MAS) frequencies (omega(r)/2pi = 65 kHz). Specifically, by combining PAR mixing with low power heteronuclear decoupling (omega(1H)/2pi approximately 16 kHz) and high spinning frequencies, we obtain high resolution 2D spectra displaying long-range (13)C-(13)C contacts from which distance estimates can be extracted. These experiments therefore demonstrate the possibility of performing high resolution structural studies in the limit of high spinning frequency and low power (1)H decoupling, a regime which optimizes the resolution of protein samples and preserves their integrity.
Studies on the Methods for Measuring Pitting Potential and a Few Environmental Factors Affecting Pitting Potential of Stainless Steels (1974)

Pretreatment methods were studies on measuring the pitting potentials free from crevice corrosion, and it has been recognized that the pitting potentials of some stainless steels can be measured with reproducibility and ease by anodic oxidation method in H2SO4 solution.On the effect of a few environmental factors on the pitting potentials, the following results have been obtained:(1) The pitting potential is also shifted to more noble values by presence of SO42- in the case of ferritic stainless steels similar to austenitic stainless steels.(2) Values of pitting potentials (EX-) are linear with logarithm of Cl- concentration (CX-), following the equation:EX-=blogCX-+a(3) The effect of various halogen ions on the pitting potentials is different in various stainless steels.SUS304, 430; (noble) I->Br->Cl- (less noble)SUS316, 26Cr-1Mo; (noble) Cl->Br- (less noble)(4) The correlation between immersion pitting tests and anodic pitting tests is recognized. and the pitting potential obtained by using the anodic oxidation method becomes a guide to predict the resistance to pitting corrosion.
Use of a least absolute shrinkage and selection operator (LASSO) model to selected ion flow tube mass spectrometry (SIFT-MS) analysis of exhaled breath to predict the efficacy of dialysis: a pilot study (2016)

Selected ion flow tube-mass spectrometry (SIFT-MS) provides rapid, non-invasive measurements of a full-mass scan of volatile compounds in exhaled breath. Although various studies have suggested that breath metabolites may be indicators of human disease status, many of these studies have included few breath samples and large numbers of compounds, limiting their power to detect significant metabolites. This study employed a least absolute shrinkage and selective operator (LASSO) approach to SIFT-MS data of breath samples to preliminarily evaluate the ability of exhaled breath findings to monitor the efficacy of dialysis in hemodialysis patients. A process of model building and validation showed that blood creatinine and urea concentrations could be accurately predicted by LASSO-selected masses. Using various precursors, the LASSO models were able to predict creatinine and urea concentrations with high adjusted R-square (>80%) values. The correlation between actual concentrations and concentrations predicted by the LASSO model (using precursor H<sub>3</sub>O<sup>+</sup>) was high (Pearson correlation coefficient = 0.96). Moreover, use of full mass scan data provided a better prediction than compounds from selected ion mode. These findings warrant further investigations in larger patient cohorts. By employing a more powerful statistical approach to predict disease outcomes, breath analysis using SIFT-MS technology could be applicable in future to daily medical diagnoses.
Bradykinin inhibits M current via phospholipase C and Ca <sup>2+</sup> release from IP <sub>3</sub> -sensitive Ca <sup>2+</sup> stores in rat sympathetic neurons (1998)

A variety of intracellular signaling pathways can modulate the properties of voltage-gated ion channels. Some of them are well characterized. However, the diffusible second messenger mediating suppression of M current via G protein-coupled receptors has not been identified. In superior cervical ganglion neurons, we find that the signaling pathways underlying M current inhibition by B2 bradykinin and M1 muscarinic receptors respond very differently to inhibitors. The bradykinin pathway was suppressed by the phospholipase C inhibitor U-73122, by blocking the IP3 receptor with pentosan polysulfate or heparin, and by buffering intracellular calcium, and it was occluded by allowing IP3 to diffuse into the cytoplasm via a patch pipette. By contrast, the muscarinic pathway was not disrupted by any of these treatments. The addition of bradykinin was accompanied by a [Ca2+]i rise with a similar onset and time to peak as the inhibition of M current. The M current inhibition and the rise of [Ca2+]i were blocked by depletion of Ca2+ internal stores by thapsigargin. We conclude that bradykinin receptors inhibit M current of sympathetic neurons by activating phospholipase C and releasing Ca2+ from IP3-sensitive Ca2+ stores, whereas muscarinic receptors do not use the phospholipase C pathway to inhibit M current channels.
Statistical Molecular Design of Balanced Compound Libraries for QSAR Modeling (2010)

A fundamental step in preclinical drug development is the computation of quantitative structure-activity relationship (QSAR) models, i.e. models that link chemical features of compounds with activities towards a target macromolecule associated with the initiation or progression of a disease. QSAR models are computed by combining information on the physicochemical and structural features of a library of congeneric compounds, typically assembled from two or more building blocks, and biological data from one or more in vitro assays. Since the models provide information on features affecting the compounds' biological activity they can be used as guides for further optimization. However, in order for a QSAR model to be relevant to the targeted disease, and drug development in general, the compound library used must contain molecules with balanced variation of the features spanning the chemical space believed to be important for interaction with the biological target. In addition, the assays used must be robust and deliver high quality data that are directly related to the function of the biological target and the associated disease state. In this review, we discuss and exemplify the concept of statistical molecular design (SMD) in the selection of building blocks and final synthetic targets (i.e. compounds to synthesize) to generate information-rich, balanced libraries for biological testing and computation of QSAR models.
L-2-hydroxyglutaric aciduria: novel mutations in the L-2-hydroxyglutarate dehydrogenase gene (2005)

L-2-HGA is a rare autosomal recessive neurrometabolic disorder, which was recently described to be caused by mutations in the L-2-HGA gene. WE therefore investigated if this gene caused the disease in 20 unrelated families (24 patients.
Solid Particle Erosion Downstream of an Orifice (2014)

The paper deals with solid particle erosion downstream of a sharp-edged orifice commonly found in many chemical processing industries. The orifice is installed in a pipe that is long enough to ensure fully developed turbulent flow in both upstream and downstream directions. Both the k-ε model and the Lagrangian particle-tracking technique were used for predicting solid particle trajectories. Gambit 2.2 was used to construct the computational grid and the commercial Fluent 12.1 code was used to perform the calculations. The available erosion correlations were used for determination of erosion characteristics considering carbon steel and aluminum pipes. The investigation was carried out for a flow restricting orifice of fixed geometry and pipe flow velocities in the range 1–4 m/s using solid particle of diameters 50–500 μm. The results indicated two critical erosion regions downstream of the orifice: the first is in the immediate neighborhood of the orifice plate and the second is in the flow reattachment zone. The results showed also a strong dependence of erosion on both particle size and flow velocity.