gebhart/patrepeval huggingface dataset:
Management of Superficial Barrett's Epithelium-Related Neoplasms by Endoscopic Mucosal Resection (2005)

Endoscopic mucosal resection (EMR), a relatively new endoluminal therapeutic technique with low morbidity and no mortality reported to date, is advocated for the treatment of Barrett's esophagus (BE)-related superficial neoplasms. However, recent studies revise its success downward, particularly regarding the ability to achieve complete excision. To evaluate what remains an evolving technique, we analyzed our experience with a series of 27 esophageal EMRs (20 lesions in 18 patients). Our goal was to evaluate the diagnostic, staging, and therapeutic advantages of EMR separately by correlating the initial biopsies and pre-EMR endoscopic ultrasound (EUS) staging with the final histologic diagnoses and stage. Persistence/recurrence of neoplastic tissue was also correlated with the margin status of the resections. The mean size of the neoplasms, which included low-grade dysplasias (n=2), high-grade dysplasias (n=8), intramucosal carcinomas (n=14), and submucosal invasive carcinomas (n=3), was 11 mm. EUS correctly reported an intramucosal or submucosal lesion in 70% of the cases while it overstaged 18% and understaged 12% of the cases. The biopsy diagnosis corresponded to the EMR diagnosis in 63% of the cases. The biopsy underestimated the grade of the lesion in 21% of the cases. EMR revealed a lower histologic grade compared with the biopsy in 16% of the cases. The resection was microscopically complete in only 4% of the cases. No residual/recurrent disease was observed in 10 lesions (9 patients) at 4 to 63 months (mean, 23 months) post-EMR. However, 9 lesions (8 patients) persisted/recurred 28 days to 25 months (mean, 6 months) after treatment; 56% of the cases with positive lateral margin(s) and negative deep margin persisted/recurred. However, 86% of the EMRs with positive deep margin showed residual tumor/recurrence on follow-up biopsies. In conclusion, we observed that EMR offers improved diagnosis and staging as compared with biopsy and EUS. This is a significant advantage since it can modify patients' management. However, frequent incompleteness of resection and high persistence/recurrence are significant pitfalls that dictate continued endoscopic surveillance.
Fifteen-year quest for microphthalmia-associated transcription factor target genes (2009)

Microphthalmia-associated transcription factor (MITF) was initially shown to play a key role in melanocyte differentiation through the direct transcriptional control of TYROSINASE, TYRP1 and DCT genes, encoding the three enzymes involved in melanin synthesis or melanogenesis. Sixteen years after the first description of MITF, more than 40 direct MITF target genes have been described. They play a key role in melanocyte, osteoclast and mast cell specific functions. Furthermore, several MITF target genes, e.g. BCL2, CDK2, CDKN1A, CDKN2A, MET and HIF1A, link MITF to general cellular processes such as growth or survival. In this review, we provide an overview of the MITF-regulated genes. We pay special attention to the MITF target genes in melanocytes and raise questions about target specificity.
Simultaneous infection with non‐A, non‐B and B viruses in a patient exhibiting different histologic patterns of acute hepatitis (1983)

We present the case of an elderly female patient who developed acute and severe hepatitis with two distinct peaks following blood transfusion. The serological markers and histopathology during the first attack were characteristic for hepatitis non-A, non-B(NANBH), whereas the second peak was due to hepatitis B virus (HBV) infection. Electron microscopy revealed morphologic equivalents for both hepatitis agents.
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding (2002)

Cyclic nucleotide phosphodiesterases (PDEs) regulate all pathways that use cGMP or cAMP as a second messenger. Five of the 11 PDE families have regulatory segments containing GAF domains, 3 of which are known to bind cGMP. In PDE2 binding of cGMP to the GAF domain causes an activation of the catalytic activity by a mechanism that apparently is shared even in the adenylyl cyclase of Anabaena, an organism separated from mouse by 2 billion years of evolution. The 2.9-A crystal structure of the mouse PDE2A regulatory segment reported in this paper reveals that the GAF A domain functions as a dimerization locus. The GAF B domain shows a deeply buried cGMP displaying a new cGMP-binding motif and is the first atomic structure of a physiological cGMP receptor with bound cGMP. Moreover, this cGMP site is located well away from the region predicted by previous mutagenesis and structural genomic approaches.
A 6.25 ns random access 0.25 μm embedded DRAM (2002)

A new embedded DRAM architecture with uniform low latency operation was developed for computing, signal processing, and networking applications. Two hard macro blocks 104 K/spl times/24b and 104 K/spl times/16b, were implemented in a 0.25 micron stacked capacitor blended logic DRAM process. The combination of novel control architecture, circuit design, and physical implementation permitted a simulated worst case row access cycle time of 6.25 ns.
Case 36-1970 (1970)

Presentation of CaseA 45-year-old man was admitted to the hospital because of dyspnea.For 20 years he had experienced mild attacks of asthma, limited to the summer months. Eleven months before admission diabetes and hypertension were found. Tolazamide was given for two weeks, and a diet was prescribed; he lost 9 kg in weight and thereafter regulated the diabetes with diet alone. Sodium restriction and oral medication were prescribed for hypertension but were omitted six months later when the blood pressure was found to be normal. Seven months before entry he was admitted to another hospital because of palpitation. . . .
Antitumor effects of anti-CD137 mAb are influenced by Fc: Fcγ receptor interactions (156.5) (2011)

Abstract In various preclinical models, agonist antibodies directed against CD137 (4-1BB) enhance the antitumor immunity. However, the contribution of the Fc:Fc receptor interactions to the process of anti-CD137 mediated tumor rejection is unknown. In this study, we provide early evidence that treatment of tumor bearing mice lacking all activating Fcγ receptors (Fcγ chain deficient mice) with the anti-CD137 mAb, 4-1BB2A, improves the survival compared to wild type mice. When Fcγ chain deficient mice and wild type are challenged with EL4E7 tumor cells, tumors were allowed to grow to an approximate size of 10mm by day 7 or 12mm by day 10. When the mice are treated with anti-CD137 mAb, the Fcγ chain deficient mice had increased survival compared to wild type mice even bearing ten day established tumors. Similarly, improved survival is seen in FcγRIII deficient mice bearing ten day established tumors after treatment with anti-CD137 mAb. While still preliminary, our observations suggest that strategies to modify Fc:FcR interactions may improve the therapeutic efficacy of anti-CD137 based cancer immunotherapy.
Measurement of the elastic modulus of spider mite silk fibers using atomic force microscopy (2013)

Bio-nanomaterials are one of the fastest developing sectors of industry and technology. Spider silk, a highly attractive light-weight biomaterial, has high tensile strength and elasticity and is compatible with human tissues, allowing for many areas of application. In comparison to spider silk fibers with diameters of several micrometers, spider mite silk fibers have much smaller diameters of tens of nanometers, making conventional tensile testing methods impractical. To determine the mechanical properties of adult and larval Tetranychus urticae silk fibers, we have performed three-point bending tests with an atomic force microscope. We found that because of the small diameters of these fibers, axial tension—due to both the applied force and a pre-existing strain—has a significant effect on the fiber response, even in the small-deformation limit. As a result, the typical Euler-Bernoulli-Timoshenko theory cannot be applied. We therefore follow the approach of Heidelberg et al. to develop a mechanical model of the fiber response that accounts for bending, an initial tension in the fibers, and a tension due to elongation during testing. This model provides self-consistent results, allowing us to determine that adult and larval fibers have Young's moduli of 24±3 GPa and 15±3 GPa, respectively. Both adult and larval fibers have an estimated ultimate strength of 200–300 MPa and a toughness of order 9 MJ/m3. We note that with increasing interest in the mechanical properties of very high aspect ratio nanomaterials, the influence of pre-existing tension must be considered in any measurements involving a bending test.
L1 phonetic drift in Dutch L2 speakers of English (2015)

This longitudinal study examines the development of voice onset time (VOT) for the stops /t/ and /d/ and the central frequency of the /s/ sibilant in a group of fluent L2 speakers of English whose L1 is Dutch, over a period of 3 years. The speakers are Dutch students who live and study at a residential college where the lingua franca is English. The student community is international, with ca. 60% being Dutch L1 speakers, and the remaining 40% comprising over 30 different L1s. A detailed description of the making of this corpus can be found in [5]. The core hypothesis which motivated the collection of this corpus is that, over the three years of these students’ undergraduate study, their accents of English will gradually converge to some kind of UCU Accent of English, which is not a native accent for any speaker. As part of this convergence, the influence of the Dutch accent of English is expected to play a large role, since the Dutch population forms the majority. For this study, we look at possible phonetic drift in word-initial /d/ and /t/, and the sibilant /s/, which are realised differently in Dutch and english. In nonclustered word-initial position, typical VOT values for Dutch voiceless stop /t/ and the English voiced stop /d/ are quite similar. Dutch voiced stops have a shorter lag time and English voiceless stops have a much longer lag time, being generally aspirated. Dutch has only one sibilant /s/ whereas English has two, namely /s/ and /S/ [3, 2]. The articulation of the Dutch /s/ is described as being somewhere between the two English sibilants, having a more retracted position of articulation, a flatter tongue, and more lip rounding [3]. Because these particular phonemes exhibit phonetic, rather than phonemic differences in Dutch and English, it is interesting to explore them in the context of Flege’s speech learning model (SLM), which suggests that the ability to perceive within-phoneme differences between an L1 and an L2 may drive the formation of a new phonetic category within a single phoneme [7]. Conversely, if a speaker does not perceive the difference, this new category may not be formed at all, but both L1 and L2 values will assimilate towards each other. We hypothesize that this will be the case for the Dutch L1 speakers’ VOT values for /t/ and /d/, and for the production of /s/.
A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patients (2001)

PDT is a cost-effective alternative to ST. The reduction in patient charges associated with PDT in this study resulted from the procedure being performed in the intensive care unit, thus eliminating the need for operating room facilities and personnel. PDT may become the procedure of choice for electively establishing tracheostomy in the appropriately selected patient who requires long-term mechanical ventilation.
Deep-Learning Assisted High-Resolution Binocular Stereo Depth Reconstruction (2020)

This work presents dense stereo reconstruction using high-resolution images for infrastructure inspections. The state-of-the-art stereo reconstruction methods, both learning and non-learning ones, consume too much computational resource on high-resolution data. Recent learning-based methods achieve top ranks on most benchmarks. However, they suffer from the generalization issue due to lack of task-specific training data. We propose to use a less resource demanding non-learning method, guided by a learning-based model, to handle high-resolution images and achieve accurate stereo reconstruction. The deep-learning model produces an initial disparity prediction with uncertainty for each pixel of the down-sampled stereo image pair. The uncertainty serves as a self-measurement of its generalization ability and the perpixel searching range around the initially predicted disparity. The downstream process performs a modified version of the Semi-Global Block Matching method with the up-sampled perpixel searching range. The proposed deep-learning assisted method is evaluated on the Middlebury dataset and high-resolution stereo images collected by our customized binocular stereo camera. The combination of learning and non-learning methods achieves better performance on 12 out of 15 cases of the Middlebury dataset. In our infrastructure inspection experiments, the average 3D reconstruction error is less than 0.004m.
A TEN YEAR REVIEW OF STRESS FRACTURES (2001)

This study reviews a ten year history of division one college athletes in a single institution who were seen by the athletic training dept. staff with symptoms consistent with lower extremity stress fracture. This institution sponsors 11 womens' sports and 11 mens' sports. Over the ten-year period of this review approximately 6,000 athletes participated in these sports. A confirmatory diagnosis of stress fractures in this population was made by x-ray, MRI, and/or bone scan. 83 athletes presented with symptoms clinically suspicious for a lower extremity stress fracture. 6 of these athletes had negative MRI's and were excluded from this project. Stress fractures were diagnosed in 32 males and 45 females. The stress fractures were grouped into the following locations: Femur, Tibia, Fibula, Foot (Mid-hind) and Forefoot (metatarsal and phalanx). A review of the location of the stress fractures by sport revealed the following profiles. All teams with the exception of football and wrestling followed the same treatment protocol for diagnosis and return to activity and are the basis for our subsequent analyses. These 74 remaining stress fractures diagnosed by MRI were graded on a scale of 1–4. Time to return to limited and full activity were obtained from a retrospective review of training room charts. We also evaluated the year of the stress fracture diagnosis in comparison to the presence of a new head coach. Time to full return to sport was dependent on stress fracture grade. Mean time to return to sport for Grade I stress fractures was 2.91(2.81, 0–11) weeks, Grade II was 5.25 (3.88, 0–10) weeks, Grade III was 10.08 (3.25, 3–16) weeks, Grade IV was 12.10 (7.16, 5–24). 28% of athletes in the first year of a new tenure of a coach had stress fractures. When Grade I and II stress fractures were combined and then compared to Grade III and IV stress fractures there was a significant difference in the time to return to full activity (p = .000). Chi-square showed a significant relationship between the presence of a new coach and the occurrence of stress fractures χ = .022. This descriptive project provides us with a profile by sport of location of stress fracture. Using MRI to define the grade of stress fracture can be useful in prediction of time to return to limited and full sport participation.TABLE: Stress Fracture Location by Sport
Protocoles de transmission de données (1997)

Les protocoles de transmission de données sont ceux qui permettent à deux entités de communiquer à travers un réseau de télécommunications. Un protocole est un ensemble de règles à respecter pour que ces deux entités puissent s’échanger de l’information. Ces règles peuvent être simples comme, par ex
Sensitivity of the resonant ultrasound spectroscopy to weak gradients of elastic properties (2012)

The applicability of resonant ultrasound spectroscopy on materials with weak spatial gradients in elastic coefficients and density is analyzed. It is shown that such gradients do not affect measurably the resonant spectrum but have a significant impact on the modal shapes. A numerical inverse procedure is proposed to explore the possibility of reconstructing the gradients from experimentally obtained modal shapes. This procedure is tested on synthetic data and applied to determine the gradient of the shear modulus in a continuously graded silicon nitride ceramic material. The results are in a good agreement with the gradient calculated for the examined material theoretically as well as with the results of other experimental methods.
ChemInform Abstract: Synthetic Studies on Azadirachtin: Asymmetric Synthesis of the Tetracyclic Decalin Part (I) of Azadirachtin. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biooxidations of Some N‐Arylpiperidines and Related Compounds Using Beauveria sulfurescens. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Shock synthesis of niobium silicides (1994)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation L. H. Yu, W. J. Nellis, M. A. Meyers, K. S. Vecchio; Shock synthesis of niobium silicides. AIP Conf. Proc. 10 July 1994; 309 (1): 1291–1294. https://doi.org/10.1063/1.46447 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Pick Your Layers Wisely - A Quality Assessment of H.264 Scalable Video Coding for Mobile Devices (2009)

Multi-dimensional video scalability as defined in H.264/SVC is a promising concept to efficiently adapt encoded streams to individual device capabilities and network conditions. However, we still lack a thorough understanding of how to automate scaling procedure in order to achieve an optimal quality of experience (QoE) for end uses.

In this paper we present and discuss the results of a subjective quality assessment we performed on mobile devices to investigate the effects of multi-dimensional scalability on human quality perception. Our study reveals that QoE degrades nonmonotonically with bitrate and that scaling order preferences are content-dependent. We confirm previous studies which found common objective metrics to fail for scalable content, but we also show that even scalability-aware models perform poor. Our results are supposed to help improving the design of quality metrics and adaptive network services for scalable streaming applications.
P3‐186: Moderate Consumption of Alcohol Modifies The Risk of Alzheimer’s Disease and is Associated with Lower Levels of Cortisol (2016)

The search for a definitive set of validated blood based biomarkers that relate directly to either Alzheimer’s disease (AD) pathology, or the onset of clinical symptoms is far from complete. A possible reason for this, is the underlying biological interaction between lifestyle and biology. In the current study we investigate the relationship between the well know stress hormone cortisol, and alcohol consumption with regards to risk of AD. We extracted biomarker, demographic and lifestyle data from healthy control (HC) and AD participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Using logistic regression, we tested for the presence of biological interaction between cortisol and alcohol consumption. Morning fasted cortisol levels were measured using a commercial enzyme-linked immunosorbent assay (ELISA; IBL International GmbH). Reported alcohol consumption was categorized into none vs any, and more specifically, individuals consuming only wine vs no alcohol. These findings demonstrate the benefit of regular moderate consumption of alcohol to combat the increased risk of AD due to the stress hormone cortisol.
A Comparative Study of Pyrolysis Liquids by Slow Pyrolysis of Industrial Hemp Leaves, Hurds and Roots (2021)

This study assessed the pyrolysis liquids obtained by slow pyrolysis of industrial hemp leaves, hurds, and roots. The liquids recovered between a pyrolysis temperature of 275-350 °C, at two condensation temperatures 130 °C and 70 °C, were analyzed. Aqueous and bio-oil pyrolysis liquids were produced and analyzed by proton nuclear magnetic resonance (NMR), gas chromatography-mass spectrometry (GC-MS), and atmospheric pressure photoionization Fourier transform ion cyclotron resonance mass spectrometry (APPI FT-ICR MS). NMR revealed quantitative concentrations of the most abundant compounds in the aqueous fractions and compound groups in the oily fractions. In the aqueous fractions, the concentration range of acetic acid was 50-241 gL<sup>-1</sup>, methanol 2-30 gL<sup>-1</sup>, propanoic acid 5-20 gL<sup>-1</sup>, and 1-hydroxybutan-2-one 2 gL<sup>-1</sup>. GC-MS was used to compare the compositions of the volatile compounds and APPI FT-ICR MS was utilized to determine the most abundant higher molecular weight compounds. The different obtained pyrolysis liquids (aqueous and oily) had various volatile and nonvolatile compounds such as acetic acid, 2,6-dimethoxyphenol, 2-methoxyphenol, and cannabidiol. This study provides a detailed understanding of the chemical composition of pyrolysis liquids from different parts of the industrial hemp plant and assesses their possible economic potential.
Episodic weakness, cerebellar ataxia, deafness and optic atrophy - a new phenotype of a novel ATP1A3 mutation (2014)

Introduction: Todelineate the molecular basis for a novel genetic syndrome in a mother and hertwo children. The syndrome is characterized by infantile acute onset severe muscleweakness episodes, ataxia , remitting gradually but recur and became permanentin adulthood associated with acquired permanent areflexia, progressive sensorineuralhearing loss and optic atrophy. Methods:Sequencingthe mitochondrial DNA and sequencing and MLPA of the OPA1 gene were applied toexclude mitochondrial disease in general and OPA1 plus related diseasespecifically which were suggestive by inheritance pattern and the involvedsystems. Whole exome sequencing was performed on all patients and Sangersequencing was subsequently used to verify the mutation in the patients andasses segregation within the family.Results:Wholeexome sequencing revealed a previously unreported E818K mutation in the ATP1A3gene in all three patients. Sanger sequencing confirmed mutation presence inthe patients and its absence in all nine unaffected family members that werechecked. Conclusion:ATP1A3gene was implicated in the last decade as the causative gene of two distinctdiseases - rapid onset dystonia parkinsonism (RDP) and alternating hemiplegiaof childhood (AHC). The clinicalpresentation in the family described in here differs significantly from thesetwo diseases by the predominance of ataxia rather than extrapyramidal movementdisorder that prevail in DRP and AHC and by the peripheral neural systeminvolvement (e.g weakness, areflexia, hearing loss and optic nerve pallor ).We conclude that ATP1A3 mutation is the cause of a novel distinct ADgenetic syndrome.