gebhart/patrepeval huggingface dataset:
Prospective Case Series of Cutaneous Adverse Effects Associated With Dabrafenib and Trametinib (2016)

Selective BRAF inhibitor dabrafenib and MEK inhibitor trametinib are associated with multiple skin adverse effects. Given their recent approval and the potential for malignant lesions to develop on treatment, awareness of potential adverse effects and their management is necessary.
Incomplete Spinal Cord Injury: Incomplete Support (2009)

Incomplete spinal cord injury (ISCI) refers to a spinal cord injury (SCI) leaving a person with considerable sensation and function below the site of the injury. Impairments caused by the injury can often be invisible, and people who sustain an ISC I yet retain the ability to walk face unique psychosocial issues. With a view to documenting their experience and the implications for support services, I conducted a focus group study with six adults who have sustained an ISCI, and who can walk. The findings of this qualitative study reveal that the impairments associated with ISCI are largely misunderstood by society in general, and by those who shape services designed to support people with disabilities. Lack of understanding can lead to denial of appropriate resources that would facilitate achievement of a satisfactory quality of life. This study is based in structural theory and aims to shed light on the broad socio-political context.
Modeling the pulse line ion accelerator (PLIA): an algorithm for quasi-static field solution (2007)

The pulse-line ion accelerator (PLIA) is a helical distributed transmission line. A rising pulse applied to the upstream end appears as a moving spatial voltage ramp, on which an ion pulse can be accelerated. This is a promising approach to acceleration and longitudinal compression of an ion beam at high line charge density. In most of the studies carried out to date, using both a simple code for longitudinal beam dynamics and the Warp PIC code, a circuit model for the wave behavior was employed; in Warp, the helix I and V are source terms in elliptic equations for E and B. However, it appears possible to obtain improved fidelity using a "sheath helix" model in the quasi-static limit. Here we describe an algorithmic approach that may be used to effect such a solution.
Presclerotized eggshell protein from the liver fluke Fasciola hepatica (1987)

Trematode parasites protect their eggs with a tough tanned eggshell. Eggshell precursor proteins are synthesized and stockpiled within the extensive vitellaria of the animal. A major eggshell precursor protein with an apparent molecular weight of 31,000 and pI of 7.4 was isolated from the vitellaria of Fasciola hepatica. This protein, which represents 6-7% of the total protein in mature Fasciola, is unique in containing rather high levels of the amino acid 3,4-dihydroxyphenylalanine (DOPA), i.e., 110 residues per 1000. Other prominent amino acids are glycine, aspartic acid, and lysine. A prominent DOPA-containing tryptic peptide derived from eggshell precursor protein has the sequence Gly-Gly-Gly-DOPA-Gly-Gly-DOPA-Gly-Lys. DOPA residues disappear during the maturation of the eggshell and by treatment in vitro with mushroom polyphenol oxidase. This disappearance may be related to the formation of cross-links in the eggshell protein.
SEG's 2006 Member Compensation Survey (2007)

Approximately 40% of SEG members have an annual base salary, exclusive of incentives and expatriate benefits, between $US100 000 and 200 000, according to the Member Compensation Survey conducted by the Bureau for Social Research at Oklahoma State University in the summer of 2006 (Table 1).
[Avastin a treatment of diabetic macular edema]. (2011)

Macular edema is the first cause of visual impairment in diabetic patient. This paper is a retrospective evaluation of a group of patients with diabetic retinopathy and macular edema, treated with intravitreal Avastin (Bevacizumab) injection. The patients have been monitored mainly by assessing the evolution of visual acuity and macular thickness (OCT), after treatment, and the results have been compared with preexisting literature data.
Inflammatory Mechanisms in Myocardial Infarction (2003)

Myocardial infarction is associated with an inflammatory response, ultimately leading to healing and scar formation. Reperfused myocardial infarcts exhibit an enhanced inflammatory reaction, and are associated with improved cardiac repair and patient survival. This review summarizes our current knowledge of the inflammatory mechanisms mediating injury and repair following myocardial ischemia and reperfusion. Myocardial necrosis is associated with complement activation and free radical generation, triggering a cytokine cascade and chemokine upregulation. Interleukin (IL)-8 and C5a are released in the ischemic myocardium, and may have a crucial role in neutrophil recruitment. Extravasated neutrophils may induce potent cytotoxic effects through the release of proteolytic enzymes and the adhesion with Intercellular Adhesion Molecule (ICAM)-1 expressing cardiomyocytes. However, despite these potentially injurious effects, the post-reperfusion inflammatory response may significantly enhance healing. Monocyte Chemoattractant Protein (MCP)-1 is induced in the infarcted area and may regulate mononuclear cell recruitment. Accumulation of monocyte-derived macrophages, and mast cells may increase expression of growth factors inducing angiogenesis and fibroblast accumulation in the infarct. In addition, expression of cytokines inhibiting the inflammatory response, such as Interleukin (IL)-10 may suppress injury. Matrix Metalloproteinases (MMPs) and their inhibitors regulate extracellular matrix deposition and play an important role in mediating ventricular remodeling. Inflammatory mediators may induce recruitment of blood-derived primitive stem cells in the healing infarct, which may differentiate into endothelial cells and even lead to limited myocardial regeneration. Understanding the cellular and molecular steps involved in regulating infarct healing may lead to specific interventions aimed at optimizing cardiac repair.
Application of Memory-Based Digital Filtering to High-Speed Digital Radio (1990)

Memory-based digital filtering is considered in the context of high-speed (greater than 15 Mbaud) radio systems, where it finds application as an accurate and rapid approach to synthesizing band-limited data signals for transmission over Nyquist channels. Following brief comments regarding the basic circuit architecture, feasibility models for 16- and 64-QAM 90-Mb/s operation are experimentally evaluated. Performance is found to be consistent with digital radio objectives and superior to sophisticated analog designs.
USING THERMOCHRONOLOGY TO UNDERSTAND OROGENIC EROSION (2006)

Erosion of orogenic mountain ranges exhumes deeply buried rocks and controls weathering, climate, and sediment production and transport at a variety of scales. Erosion also affects the topographic form and kinematics of orogens, and it may provide dynamic feedbacks between climate and tectonics by spatially focused erosion and rock uplift. Thermochronology measures the timing and rates at which rocks approach the surface and cool as a result of exhumation. Relatively well-understood noble gas and fission-track thermochronometric systems have closure temperatures ranging from ∼60 to ∼550°C, making them sensitive to exhumation through crustal depths of about one to tens of kilometers. Thus, thermochronology can constrain erosion rates and their spatial-temporal variations on timescales of ∼10 5 –10 7 years, commensurate with orogenic growth and decay cycles and possible climate-tectonic feedback response times. Useful methods for estimating erosion rates include inverting ages for erosion rates using crustal thermal models, vertical transects, and detrital approaches. Spatial-temporal patterns of thermochronometrically determined erosion rates help constrain flow of material through orogenic wedges, orogenic growth and decay cycles, paleorelief, and relationships with structural, geomorphic, or climatic features.
Pyrroles XIV. Mannich Bases of 2,5-Substituted Pyrroles<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrroles XIV. Mannich Bases of 2,5-Substituted Pyrroles1WERNER HERZ and ROBERT L. SETTINECite this: J. Org. Chem. 1959, 24, 2, 201–204Publication Date (Print):February 1, 1959Publication History Published online1 May 2002Published inissue 1 February 1959https://pubs.acs.org/doi/10.1021/jo01084a013https://doi.org/10.1021/jo01084a013research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake. (1994)

The CTR1 gene of Saccharomyces cerevisiae encodes a protein required for high affinity copper uptake. The protein is expressed on the plasma membrane, is heavily glycosylated with O-linkages, and exists as an oligomer in vivo. The transcript abundance is strongly regulated by copper availability, being induced by copper deprivation and repressed by copper excess. Regulation occurs at very low, nontoxic levels of available copper and is independent of ACE1, the trans-inducer of yeast metallothionein. Expression of Ctr1p is limiting for copper uptake, since overexpression from a 2 mu high copy number plasmid increases copper uptake. Mutations in CTR1 result in altered cellular responses to extracellular copper, demonstrating a physiologic role for CTR1 in the delivery of copper to the cytosol. A copper-dependent reporter gene construct, CUP1-lacZ, is not expressed in CTR1 mutants to the same level as in wild-type strains, and Cu,Zn superoxide dismutase activity is deficient in these mutants. The growth arrest that occurs in CTR1 mutants grown aerobically in copper-deficient media is attributable to the defect in Cu,Zn superoxide dismutase activity.
Biopolymers in Light Emitting Devices (2006)

In this paper we describe DNA based fluorescent thin films and light emitting diodes and compare their current performance and future prospects to conventional organic counterparts.
The earliest metanephric arteriolar progenitors and their role in kidney vascular development (2014)

The development of the kidney arterioles is poorly understood. Mature arterioles contain several functionally and morphologically distinct cell types, including smooth muscle, endothelial, and juxtaglomerular cells, and they are surrounded by interconnected pericytes, fibroblasts, and other interstitial cells. We have shown that the embryonic kidney possesses all of the necessary precursors for the development of the renal arterial tree, and those precursors assemble in situ to form the kidney arterioles. However, the identity of those precursors was unclear. Within the embryonic kidney, several putative progenitors marked by the expression of either the winged-forkhead transcription factor 1 (Foxd1+ progenitor), the aspartyl-protease renin (Ren+ progenitor), and/or hemangioblasts (Scl+ progenitor) are likely to differentiate and endow most of the cells of the renal arterial tree. However, the lineage relationships and the role of these distinct progenitors in renal vascular morphogenesis have not been delineated. We, therefore, designed a series of experiments to ascertain the hierarchical lineage relationships between Foxd1+ and Ren+ progenitors and the role of these two precursors in the morphogenesis and patterning of the renal arterial tree. Results show that 1) Foxd1+ cells are the precursors for all the mural cells (renin cells, smooth muscle cells, perivascular fibroblasts, and pericytes) of the renal arterial tree and glomerular mesangium, and 2) Foxd1 per se directs the origin, number, orientation, and cellular composition of the renal vessels.
Label-free Imaging of Thyroid and Parathyroid Glands Using Coherent Anti-Stokes Raman Scattering (CARS) Microscopy (2015)

Thyroid and parathyroid glands play a vital role in regulating the body's metabolism and calcium levels. Surgical removal of the glands is the main treatment for both thyroid cancer and parathyroid adenoma. In thyroidectomy and parathyroidectomy, it's very important to differentiate thyroid, parathyroid, and the other tissues around the neck. Traditionally, physicians use ultrasound guided fine needle aspiration (FNA) to evaluate thyroid nodules, but up to 30% of FNA results are “inconclusive”. The sestamibi scan can localize parathyroid adenoma, but currently it only has 50% accuracy. Here we applied the emerging CARS technique to image both thyroid and parathyroid tissues, which has potential to be used in real-time in vivo examination of different structures. We also developed algorithms to differentiate different cellular structures based on CARS images. When incorporated with a fiber optic endoscope in the future, CARS imaging technique can help surgeons identify cancerous thyroid tissue intraoperatively, preserve good parathyroid glands during thyroidectomy and find parathyroid adenoma during parathyroidectomy.
A new empirical potential for simulating the formation of defects and their mobility in uranium dioxide (2003)

An empirical interaction potential has been developed primarily to simulate displacement cascades in a UO2 matrix. After a bibliographical survey revealed that the potentials discussed in the literature are not entirely suitable for describing point defects and their migration, we decided to adapt the most representative of the existing potentials. Our objective was specifically to reproduce transport phenomena, which are fundamental to a satisfactory description of atomic displacement cascades. The modified potential more correctly describes the experimental energies of formation and migration of point defects (interstitials, vacancies, etc.) as well as the oxygen diffusion coefficients in the superionic phase. Thermal expansion, heat capacity and enthalpy are also better modelled over a wide temperature range. The new potential is much more transferable than earlier potentials fitted mainly to the properties of perfect crystals. The initial simulated atomic displacement cascades showed that this potential is well suited to the description of structural effects created by decelerating recoil nuclei in a UO2 matrix.
Frontal elution paper chromatography for ambient ionization mass spectrometry: analyzing powder samples (2013)

We developed a convenient method by coupling frontal elution paper chromatography with desorption corona beam ionization mass spectrometry (FEPC/DCBI-MS) for rapid analysis of powder samples. In this method, the powder was deposited directly onto a coarse strip near the base of a triangular paper sheet, and then a strong elution solvent was pipetted onto the base of the paper sheet in the open air for developing. The sample zone migrated at the solvent front under strong elution conditions. Target analytes were finally condensed at the V-shaped tip which was then placed under the visible plasma beam of DCBI for ionization. Steps of solvent extraction and developing were performed on a paper sheet simultaneously. The overall procedure requires less than two minutes. Signal intensities of target analytes were improved significantly due to analyte condensation at the tip and matrix effect reduction. Fundamentals and applications of FEPC/DCBI-MS were demonstrated by analysis of chlorphenamine in herbal medicines, clenbuterol in pig feed powder and nicotine in house-hold dust. The limits of detection ranged from 0.35 μg g−1 to 1.5 μg g−1 (0.52–2.2 ng, absolute) in full-scan positive-ion mode. The linear range was 5.0 μg g−1 to 5.0 × 102 μg g−1 with satisfactory linear coefficient (R2 = 0.885–0.956). Good reproducibility was achieved with relative standard deviations (RSDs) less than 20% and the recoveries ranged from 70 to 90%. The results demonstrate that the improved FEPC-DCBI-MS method is satisfactory for semi-quantitative evaluation of analytes in powder samples.
D0 muon proportional drift tube electronics test results (2002)

Test results of the proportional drift tube (PDT) electronics for the Muon Upgrade at the D0 experiment at Fermilab are described. Prototypes of two front-end boards and two readout VME modules comprising a deadtimeless readout system have been built and tested. The front-end electronics prototypes include an eight-channel front-end board and a control board. The front-end board is capable of registering PDT anode wire signals with a 1 /spl mu/A threshold and two cathode pad charges at a resolution of 5 fC. Control board features include a sequencer for collecting data from up to four front-end boards, two digital signal processors (DSP), and two serial link transmitters. A serial link transports data a 100 meters from the control board to the VME based muon readout card. The muon readout card receives timing and control signals from the muon fanout card and re-transmits them to the control board. Initial tests with internal pulsers simulating detector signals and further tests with cosmic rays are described. We have tested three data taking modes. The prototype readout system transfers PDT data without deadtime at 16 mbyte/s with a level 1 trigger rate of 10 kHz.
Composition of the capsular polysaccharides of <i>Clostridium perfringens</i> as a basis for their classification by chemotypes (1975)

An analytical procedure, using gas-liquid chromatography, was developed for the identification of the per(trimethylsilyl) ethers of the constituent monosaccharides obtained from the capsular polysaccharides of Clostridium perfringens Hobbs 5, Hobbs 9, Hobbs 10, and NCTC 10578. Qualitative and quantitative differences between the major polysaccharide components enabled the differentiation of the four strains of C. perfringens investigated.
Relationships between ecological factors and maize yield (2000)

The effect of ecoligical factors on the growth and yield of maize, the control method of ecological factors, and the effect of climate change on maize and the countermeasure were summarized to help to study maize on high and steady yield.
Hypoxia‐inducible factor 2α is essential for hypoxic induction of the human articular chondrocyte phenotype (2007)

Based on our data, we propose a novel mechanism whereby hypoxia promotes cartilage matrix synthesis specifically through HIF-2alpha-mediated SOX9 induction of key cartilage genes. These findings have potential application for the development of cartilage repair therapies.
Early Predictors of Death and Disability After Acute Cerebral Ischemic Event (1995)

In future drug trials, the distribution of patients between "active treatment" and "placebo" groups should be balanced regarding the severity of clinical deficits, history of stroke, and age.
Gerald J. Toomer (2012)

I n 1965, Gerald Toomer, a brilliant clas-sicist from Oxford, joined the department. Toomer has published fundamental studies of Greek, Arabic, and medieval Latin mathematics and of mathematical astronomy. From his pen has come a commentary on Diocles’ Burning Mirrors and a translation and annotation of Ptolemy’s Almagest. His later interests have embraced the study of English Arabists in the 17th century and through this connection he has published Eastern Wisdom and Learning: Th e Study of Arabic in Seventeenth Century England as well as John Selden: A Life in Scholarship.
Electrocatalytic Oxidation of Glucose at Carbon Nanotubes Supported PtRu Nanoparticles and Its Detection (2008)

Abstract PtRu nanoparticles were supported on multiwall carbon nanotubes (MWNTs), which were further fabricated as an electrode for nonenzymatic glucose sensing. Transmission electron microscope and X‐ray diffraction patterns were used for characterization of the PtRu nanoparticles on MWNTs. Cyclic voltammetry and chronopotentiometry were applied to investigate the performance of the PtRu/MWNTs nanocomposite electrode for nonenzymatic oxidation of glucose. The PtRu/MWNTs electrode shows high electrocatalytic activity towards the oxidation of glucose in 0.1 M NaOH solution and thus can be used to selectively detect glucose. Under the optimal potential (+0.55 V vs. Ag/AgCl), the biosensor effectively performs a selective electrochemical analysis of glucose in the presence of common interferents, such as ascorbic acid (AA), dopamine (DP) and uric acid (UA). Wide linear calibration ranging from 1 mM to 15 mM, high sensitivity of 28.26 μA cm −2 mM −1 , low detection limit of 2.5×10 −5 M, and fast response time of 10 s were achieved for the detection of glucose at the PtRu/MWNTs electrode.
Renal transport of organic anions (1998)

This review deals with the different transport mechanisms mediating the apical and basolateral transport of organic anions, all of which are restricted to the proximal tubule. Several transport mechanisms, such as the para-aminohippurate basolateral transporter and the apical proton coupled di- and tripeptide transporter have been cloned, and their role in renal transport has been well characterized. Other transport proteins have been cloned from the kidney, liver, or intestine, but their role in the renal transport of organic anions needs to be elucidated. This is the with Mdr2, oatpl and OAT-K1, which were identified in the apical membrane of the proximal tubule, and with MDR1, the precise localization of which is still uncertain. Other apical transport mechanisms, sodium coupled transports and anion exchangers are involved in organic anion reabsorption.
Influence of Strong Acid Hydrolysis Processing on the Thermal Stability and Crystallinity of Cellulose Isolated from Wheat Straw (2015)

Cellulose extractions from wheat straw via hydrochloric, nitric, and sulfuric acid hydrolysis methods were carried out. X-ray diffraction spectral analyses reveal that depending on the acid conditions used the structure of the cellulose exhibited a mixture of polymorphs (i.e., CI and CIII cellulose phases). In addition, the percent crystallinity, diameter, and length of the cellulose fibers varied tremendously as determined by X-ray diffraction and scanning electron microscopy. Thermal gravimetric analysis measurements revealed that the thermal stability of the extracted cellulose varied as a function of the acid strength and conditions used. Scanning electron microscopy analysis revealed that the aggregation of cellulose fibers during the drying process is strongly dependent upon the drying process and strength of the acids used.