gebhart/patrepeval huggingface dataset:
Complex formation by the human RAD51C and XRCC3 recombination repair proteins (2001)

In vertebrates, the RAD51 protein is required for genetic recombination, DNA repair, and cellular proliferation. Five paralogs of RAD51, known as RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3, have been identified and also shown to be required for recombination and genome stability. At the present time, however, very little is known about their biochemical properties or precise biological functions. As a first step toward understanding the roles of the RAD51 paralogs in recombination, the human RAD51C and XRCC3 proteins were overexpressed and purified from baculovirus-infected insect cells. The two proteins copurify as a complex, a property that reflects their endogenous association observed in HeLa cells. Purified RAD51C--XRCC3 complex binds single-stranded, but not duplex DNA, to form protein--DNA networks that have been visualized by electron microscopy.
The Dispersion of Standard Air* (1953)

By combining Barrell and Sears’ measurements in the visible and Koch’s and Traub’s in the ultraviolet, a dispersion formula for standard air has been derived, viz., (n−1)108=6432.8+2 949 810(146−σ2)−1+25 540(41−σ2)−1,σ being vacuum wave number in μ−1, which should satisfy all needs of precision spectroscopy, in particular for converting wavelengths in air into vacuum values.
Management of chronic hand and foot eczema. An Australia/New Zealand Clinical narrative (2020)

Chronic hand/foot eczemas are common, but treatment is often challenging, with widespread dissatisfaction over current available options. Detailed history is important, particularly with regard to potential exposure to irritants and allergens. Patch testing should be regarded as a standard investigation. Individual treatment outcomes and targets, including systemic therapy, should be discussed early with patients, restoring function being the primary goal, with clearing the skin a secondary outcome. Each new treatment, where appropriate, should be considered additive or overlapping to any previous therapy. Management extends beyond mere pharmacological or physical treatment, and requires an encompassing approach including removal or avoidance of causative factors, behavioural changes and social support. To date, there is little evidence to guide sequences or combinations of therapies. Moderately symptomatic patients (e.g. DLQI ≥ 10) should be started on a potent/super-potent topical corticosteroid applied once or twice per day for 4 weeks, with tapering to twice weekly application. If response is inadequate, consider phototherapy, and then a 12-week trial of a retinoid (alitretinoin or acitretin). Second line systemic treatments include methotrexate, ciclosporin and azathioprine. For patients presenting with severe symptomatic disease (DLQI ≥ 15), consider predniso(lo)ne 0.5-1.0 mg/kg/day (or ciclosporin 3 - 5 mg/kg/day) for 4-6 weeks with tapering, and then treating as for moderate disease as above. In non-responders, botulinum toxin and/or iontophoresis, if associated with hyperhidrosis, may sometimes help. Some patients only respond to long-term systemic corticosteroids. The data on sequencing of newer agents, such as dupilumab or JAK inhibitors, are immature.
The use of thumbtacks to stop massive presacral hemorrhage (1986)

Massive bleeding from the sacral basivertebral vein is uncommon and can be fatal because conventional methods to control the bleeding are often futile. Occlusion of the bleeding site with a titanium thumbtack is easy and effective.
A Possible Autoimmune Basis for Addison's Disease in Three Siblings, One with Idiopathic Hypoparathyroidism, Pernicious Anemia and Superficial Moniliasis (1963)

FAMILIAL Addison's disease is an uncommon entity. In 1959 Meakin, Nelson and Thorn1 reviewed the literature and found 5 cases of familial Addison's disease documented by steroid studies or autopsy findings,2 3 4 5 6 and reported another case. Since that time 4 additional cases fulfilling their criteria have been reported.7 8 9 10 The association of superficial moniliasis, idiopathic hypoparathyroidism and Addison's disease is even rarer, only 6 cases being found in the literature.11 12 13 14 15 The purpose of this report is to describe a family in which Addison's disease was present in 3 siblings, 1 of whom also had superficial moniliasis, idiopathic hypoparathyroidism and pernicious anemia. We . . .
Nalorphine-like properties of some 2,3-dimethyl-3-arylpiperidines (1978)

A number of N-substituted 2,3-dimethyl-3-arylpiperidines having an m- or p-arylhydroxyl were prepared and evaluated for analgesic agonist and antagonist properties. The diastereomeric N-allyl and N-cyclopropylmethyl derivatives behaved as pure potent antagoinists. Substitution of the arylhydroxyl from the meta to the para position resulted in a net fall of the antagoinist activity.
Reflection Seismic and Ground-penetrating Radar Study of Previously Mined (Lead/Zinc) Ground, Joplin, Missouri (1999)

A geophysical survey was conducted for the Missouri Department of Transportation (MoDOT) along segments of a proposed interstate route (Alternate “E”) near Joplin, Missouri across ground previously mined for lead and zinc. A total of 14.6 km of shallow reflection seismic data, nine down-hole seismic calibration check shots and 15 km of ground penetrating radar (GPR) data were acquired. The seismic data were acquired to map Mississippian bedrock, locate and identify paleosinkholes and abandoned mine features, and determine structural geologic trends in the study area. The GPR data were acquired to identify and locate abandoned mine access and ventilation shafts in areas that were overlain by surficial milled ore rock. Pre-construction knowledge of these anthropogenic and natural features will assist in route selection and geotechnical site mitigation, and minimize both the potential for contractor variable site condition claims and the potential for long-term subsidence-related problems. The geophysical survey was successful in meeting MoDOT goals. The interpretation of the seismic data, and corroborative engineering geologic field mapping and drilling, established that the shallow reflection seismic technique can be used in the Joplin area to map bedrock structure (including probable fault lineaments and paleosinkholes), locate abandoned, in-filled and/or caved-in open pit mines; and define areas of probable shallow mining activity. The interpretation of the GPR data established that the GPR technique can be used in the Joplin area to locate abandoned mine access and ventilation shafts, even where such shafts are in-filled and overlain by a thin veneer of mill-waste products.
Ultrafast thermal melting of laser-excited solids by homogeneous nucleation (2002)

Homogeneous nucleation is considered as a mechanism for rapid thermal melting of solids irradiated with ultrashort laser pulses. Based on classical nucleation theory we show that for sufficient superheating of the solid phase the dynamics of melting is mainly determined by the electron-lattice equilibration rather than by nucleation kinetics. Therefore, complete melting of the excited material volume should occur within a few picoseconds. This time scale lies between the longer time scale for heterogeneous, surface-nucleated melting and the shorter time scale for possible nonthermal melting mechanisms.
Fracture and flow of rocks under high triaxial compression (1971)

A new triaxial compression technique has made possible the study of laws of the fracture and flow of rocks under general triaxial stress states, in which all three principal stresses are different. By this new method, the effects of the stress states on fracture and yielding of rocks were experimentally studied. Fracture and flow properties of rocks are markedly affected not only by the least compression σ3, but also by the intermediate compression σ2. The stress states that produce fracture and yielding are determined by the following formulas: (1) (2) where ƒ1 and ƒ2 are monotonic increasing functions. The new failure criteria, corresponding to the generalized von Mises criteria, are physically interpreted as follows: fracture or yielding will occur when the distortional strain energy reaches a critical value that increases monotonically with the effective mean pressure: (σ1 + σ3)/2 for fracture and (σ1 + σ2 + σ3)/3 for yielding. The ductility defined as the permanent strain just before fracture, markedly increases with the increasing σ3 but decreases with increasing σ2. The influences of σ2 and σ3 on ductility are just the opposite. From these results on the effect of stress states, fracture and flow properties of the earth's upper mantle were deduced.
Session mobility of SIP over multiple devices (2008)

Session Initiation Protocol (SIP) has been widely applied to telephony service. SIP is also adopted as the signal communication protocol of VoIP and 3GPP, so the development of SIP receiving much concern. Currently the research of SIP can be divided into four issues, including terminal mobility, session mobility, personal mobility, and service mobility. In this paper, we address the issue of session mobility. We want to solve the problem allowing a user to transfer, split, and retrieve a session over multiple devices by using SIP. In order to provide the service, three new agents have been introduced based on the definition of user agent proposed in RFC 3261. There are session manager, session user, and free node. Based on these agents, we propose a complete mechanism, to transfer and retrieve a session over multiple devices. According to our mechanism, the user will facility transfers, splits, and retrieves a session over multiple devices. Finally, we implement the mechanism by modifying the open source project of Sip-Communicator.
In vivo depletion of CD8+ T lymphocytes abrogates protective immunity to African swine fever virus (2005)

To understand the mechanisms involved in protective immunity to African swine fever virus (ASFV) infection, the observation that infection with the avirulent Portuguese ASFV isolate OUR/T88/3 protects outbred pigs from challenge with the virulent Portuguese ASFV isolate OUR/T88/1 was exploited. It was demonstrated that pigs exposed to OUR/T88/3 and then depleted of CD8+ lymphocytes were no longer fully protected from OUR/T88/1 challenge. This indicated that CD8+ lymphocytes play an important role in the protective immune response to ASFV infection and that anti-ASFV antibody alone, from OUR/T88/3 infection, was not sufficient to protect pigs from OUR/T88/1 challenge. Inbred pigs of the cc haplotype infected with OUR/T88/3 were not always protected from OUR/T88/1 challenge and developed both viraemia and fever. Such viraemia was always correlated with increased numbers of circulating CD8beta+ lymphocytes, indicating a specific role for CD8beta+ lymphocytes in combating viraemia. These experiments indicate an important role for CD8+ lymphocytes, particularly CD8beta+ lymphocytes, in ASF protective immunity.
Oncolytic Virus Encoding a Master Pro-Inflammatory Cytokine Interleukin 12 in Cancer Immunotherapy (2020)

Oncolytic viruses (OVs) are genetically modified or naturally occurring viruses, which preferentially replicate in and kill cancer cells while sparing healthy cells, and induce anti-tumor immunity. OV-induced tumor immunity can be enhanced through viral expression of anti-tumor cytokines such as interleukin 12 (IL-12). IL-12 is a potent anti-cancer agent that promotes T-helper 1 (Th1) differentiation, facilitates T-cell-mediated killing of cancer cells, and inhibits tumor angiogenesis. Despite success in preclinical models, systemic IL-12 therapy is associated with significant toxicity in humans. Therefore, to utilize the therapeutic potential of IL-12 in OV-based cancer therapy, 25 different IL-12 expressing OVs (OV-IL12s) have been genetically engineered for local IL-12 production and tested preclinically in various cancer models. Among OV-IL12s, oncolytic herpes simplex virus encoding IL-12 (OHSV-IL12) is the furthest along in the clinic. IL-12 expression locally in the tumors avoids systemic toxicity while inducing an efficient anti-tumor immunity and synergizes with anti-angiogenic drugs or immunomodulators without compromising safety. Despite the rapidly rising interest, there are no current reviews on OV-IL12s that exploit their potential efficacy and safety to translate into human subjects. In this article, we will discuss safety, tumor-specificity, and anti-tumor immune/anti-angiogenic effects of OHSV-IL12 as mono- and combination-therapies. In addition to OHSV-IL12 viruses, we will also review other IL-12-expressing OVs and their application in cancer therapy.
Catalytic Bitumen Partial Upgrading using Methane (2016)

It is highly desired to partially upgrade viscous heavy oil, to be transportable by pipeline. Conventionally, this is achieved by expensive catalytic hydrogenation under a hydrogen pressure of 15–20 MPa. In this thesis, it is reported that by using zinc and silver cation-modified HZSM-5 as the catalyst, methane can be activated at a relatively low temperature of 380 °C and a pressure of 5 MPa to efficiently upgrade heavy oil. The product is a partially upgraded crude oil which is more desirable for pipeline transportation and downstream refining. Before the evaluation of different catalysts, the reaction conditions optimization and better support identification is carried out. The catalyst with the best upgrading performance among all developed candidates comparison was 1 wt% Ag–10 wt% Zn/HZSM-5. This study opens a door for upgrading heavy oil with natural gas.
Cardiac motion correction based on partial angle reconstructed images in x‐ray CT (2015)

The authors propose a novel PAR image-based cardiac motion estimation and compensation algorithm. The algorithm requires an angular scan range of less than 360°. The excellent performance of the proposed algorithm is illustrated by using digital XCAT and physical dynamic cardiac phantom datasets.
Computer‐assisted implantology: historical background and potential outcomes—a review (2008)

Computer-assisted/-guided/-aided implantology has been founded to overcome the errors encountered during implant osteotomies and to position the implants more precisely. The protocols followed by this sophisticated technique are based upon the advocated concept of prosthetic-driven implantology and CT-scan analysis recently approved. Although several attempts have been made to improve this approach more and more, little has been done regarding the patient's demands, including cost. The inherent complexity of the techniques and materials utilized necessitates several degrees of training before attempting treatment and must be taken into account.
Hereditary angioedema: an update on causes, manifestations and treatment (2019)

Hereditary angioedema is a rare genetic disorder caused by deficiency of C1 esterase inhibitor (C1-INH) and characterized by recurrent episodes of severe swelling that affect the limbs, face, intestinal tract and airway. Since laryngeal oedema can be life-threatening as a result of asphyxiation, correct diagnosis and management of hereditary angioedema is vital. Hereditary angioedema attacks are mediated by bradykinin, the production of which is regulated by C1-INH. Hereditary angioedema therapy relies on treatment of acute attacks, and short- and long-term prophylaxis. Acute treatment options include C1-INH concentrate, icatibant and ecallantide. Self-administration of treatment is recommended and is associated with increased quality of life of patients with hereditary angioedema. Advances in diagnosis and management have improved the outcomes and quality of life of patients with hereditary angioedema.
Flux masking and thickness uniformity in molecular beam epitaxy (1995)

We suggest that properly designed masks altering the rotation-integrated flux arriving at the substrate may be used to improve thickness uniformity in a variety of crystal growth techniques. As an illustration, we calculate the dimensions of the mask required to produce a perfectly uniform flux for a single group-III species in single- and multiple-wafer III–V molecular beam epitaxy. Estimates of the detrimental role of errors in mask machining and position are provided and schemes for correcting flux nonuniformities for multiple sources are suggested. Our results imply that flux masking can lead to significant uniformity improvements for growth on single or multiple wafers.
<i>Appendix</i>—The synthesis of aryl glycosiduronic acids (1958)

Other| April 01 1958 Appendix—The synthesis of aryl glycosiduronic acids C. A. Marsh; C. A. Marsh 1Rowett Research Institute, Bucksburn, Aberdeenshire Search for other works by this author on: This Site PubMed Google Scholar G. A. Levvy G. A. Levvy 1Rowett Research Institute, Bucksburn, Aberdeenshire Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1958) 68 (4): 617–621. https://doi.org/10.1042/bj0680617 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation C. A. Marsh, G. A. Levvy; Appendix—The synthesis of aryl glycosiduronic acids. Biochem J 1 April 1958; 68 (4): 617–621. doi: https://doi.org/10.1042/bj0680617 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search © 1958 CAMBRIDGE UNIVERSITY PRESS1958 Article PDF first page preview Close Modal You do not currently have access to this content.
A General-Purpose High-Speed Logical Transform Image Processor (1982)

A new logical transform processor has been designed and its performance presented in this correspondence. The design incorporates the speed advantage of a locally parallel processor and yet has the capability of processing images of widely ranging dimension. Sixteen pixels are processed simultaneously using table lookup. Image size and neighborhood size are under program control of the host computer, a Perkin-Elmer 3220. This logical transform processor is capable of executing picture point operations in 50 ns.
Maternal Diabetes in Pregnancy: Early and Long-Term Outcomes on the Offspring and the Concept of “Metabolic Memory” (2011)

The adverse outcomes on the offspring from maternal diabetes in pregnancy are substantially documented. In this paper, we report main knowledge on impacts of maternal diabetes on early and long-term health of the offspring, with specific comments on maternal obesity. The main adverse outcome on progenies from pregnancy complicated with maternal diabetes appears to be macrosomia, as it is commonly known that intrauterine exposure to hyperglycemia increases the risk and programs the offspring to develop diabetes and/or obesity at adulthood. This "fetal programming", due to intrauterine diabetic milieu, is termed as "metabolic memory". In gestational diabetes as well as in macrosomia, the complications include metabolic abnormalities, degraded antioxidant status, disrupted immune system and potential metabolic syndrome in adult offspring. Furthermore, there is evidence that maternal obesity may also increase the risk of obesity and diabetes in offspring. However, women with GDM possibly exhibit greater macrosomia than obese women. Obesity and diabetes in pregnancy have independent and additive effects on obstetric complications, and both require proper management. Management of gestational diabetes mellitus and maternal obesity is essential for maternal and offspring's good health. Increasing physical activity, preventing gestational weight gain, and having some qualitative nutritional habits may be beneficial during both the pregnancy and offspring's future life.
HMFPCC: - Hybrid-mode floating point conversion co-processor (2015)

This research and development on conversion co-processor presents an abstract- level hardware implementation of the conversion between various number formats for FPGAs in modular way. Replacing the floating point expressions with specialized integer or fixed point operations can greatly improve the system performance in several applications. The replacement requires several types of conversions from one format to another format. The proposed conversion co-processor accelerator can work in parallel with HOST machine to accept a large amount of input data and convert to another format and apply fixed point or integer arithmetic operations and the result is converted back to the floating point or fixed point format. The floating point conversions unit designs are fully compliant with the IEEE 754-2008 standard. The proposed system has been tested on Xilinx Virtex 6 xc6vlx550t-2ff1759 FPGA and achieves a throughput of 350MFLOPs per second.
Calcofluor white and Congo red inhibit chitin microfibril assembly of Poterioochromonas: evidence for a gap between polymerization and microfibril formation. (1980)

The influence of the light microscopical stains, Calcofluor white and Congo red, on the process of chitin microfibril formation of the chrysoflagellate alga Poterioochromonas stipitata was studied with light and electron microscopy. There is a concentration-dependent inhibition of lorica formation with both dyes. In the presence of the inhibitors malformed loricae are made, which do not show the usual ultrastructure and arrangement of the chitin microfibrils. Instead of long, laterally associated microfibrils, short rods or irregular networks of subelementary (15-25 A) fibrils are found. Microfibril assembly obviously takes place on the accessible outside of the plasma membrane. There must be a gap between the polymerization and microfibril formation reactions, allowing the stains to bind to the polymerized subunits. Thus, later association of these units to form microfibrils is disturbed. The microfibril-orienting mechanism also depends on normal microfibril formation. A model summarizing these hypotheses is suggested.
The role of fenestrated vessels for the secretory process in the nasal mucosa: A histological and transmission electron microscopic study in the rabbit (1993)

Both nasal glands and nasal vessels are supposed to be responsible for the humidification of inhaled air. After previous studies on the vasculature of the nasal septal mucosa in the rabbit, we examined vessels of the anterior concha in order to find a morphological equivalent to explain the role of endonasal vasculature in the secretory process of this tissue. The main findings of our study include the detection of fenestrated endothelial walls of both capillaries and venous sinuses located underneath and directly adjacent to the basal cell layers of the epithelium. The same phenomenon-fenestrated vessels underneath the epithelium with the fenestrated parts facing the epithelial cells-has been described in other parts of the body and has been called "polar differentiation." In accordance with the interpretations of other authors, we conclude that these features are responsible for the regulation of endonasal fluid exchange.
Regulation of gene expression by <i>trans</i>‐encoded antisense RNAs (1995)

Members of a class of antisense RNAs are encoded by genes that are located at loci other than those of their target genes. Three examples of antisense RNA genes are discussed here. micF is found in Escherichia coli and other bacteria and functions to control outer membrane protein F levels in response to environmental stimuli. dicF is also found in E. coli and is involved in the regulation of cell division. lin-4 is found in the nematode Caenorhabditis elegans and functions during larval development. Nucleotide sequences of at least two of these genes appear to be phylogenetically conserved. The trans-encoded antisense RNAs are small RNAs which display only partial complementarity to their target RNAs. Models for RNA/RNA interactions have been proposed. It is possible that currently known unlinked antisense RNA genes are part of a larger class of heretofore undiscovered regulatory RNA genes. Possible ways of detecting other unlinked antisense RNA genes are discussed.