gebhart/patrepeval huggingface dataset:
Effect of Oral Glucose Loading on Plasma Insulin, Potassium, Renin and Aldosterone in Normal Subjects and Patients with Primary Hyperaldosteronism (1982)

The effects of standard oral glucose loading (100 g) on plasma aldosterone and some regulatory factors were assessed in patients with primary hyperaldosteronism and normal subjects. Following overnight fast, mean plasma glucose was identical (10 patients and normal subjects approximately matched per age and sex); plasma insulin, potassium and renin levels were lower and plasma aldosterone higher in the patients. Glucose loading significantly increased plasma glucose and insulin concentrations and decreased plasma potassium and aldosterone levels in both groups; plasma renin activity was significantly increased only in normal subjects. The increases in plasma insulin and the decreases in plasma potassium or aldosterone tended to be blunted in primary hyperaldosteronism. Relationships among glucose-induced changes in plasma aldosterone and other factors were assessed by multiple regression analysis in these patients and normal subjects as well as an additional group of 21 normal subjects; in the latter, plasma cortisol was also measured and found to decrease significantly after glucose loading. Changes in plasma aldosterone correlated (P less than 0.025) more closely with those in plasma potassium in the patients and with variations in plasma renin activity in the normal subjects. These findings suggest that complex metabolic changes occur following glucose ingestion which are capable of modifying aldosterone secretion in normal subjects and primary hyperaldosteronism. The aldosterone-inhibitory effect of glucose tends to be blunted in the latter disorder. This could be related at least in part to an impaired insulin response in primary hyperaldosteronism.
Continuous Authentication using Fuzzy Logic (2014)

In this paper, we investigate the performance of a continuous authentication system using fuzzy logic techniques. The system monitors mouse and keystroke dynamics behaviour of a user to determine the genuineness. The objective was to design a system that is capable of detecting an impostor user as fast as possible, while not disturbing the genuine user. For our research we build a new dataset consisting of mouse and keystroke dynamics behavioural data of 52 persons, collected in a real life environment (no control over environment or performed tasks) over a period of 5-7 days.
Antibacterial efficacy of Allium Cepa, P. Emblica and Zingiber officinale against E.Faecalis in comparison to sodium hypochlorite (2015)

Topic/ Aim: To determine whether fresh juices obtained from Allium cepa, P. emblica and Zingiber officinale have antibacterial activity against E. faecalis n comparison to sodium hypochlorite. Methodology: Agar plates were prepared using Mueller Hinton Agar and cultures were grown in BHI broth at 37 degrees centigrade. Lawn culture was carried out on Mueller Hinton Agar plates. Well diffusion method was used to derive the results. Wells were cut in agar plates which were 6 mm in diameter and 4 mm in depth. Then 50, 70, 90μl of fresh juice obtained from Allium cepa, P. emblica and Zingiber officinale was poured in the wells using a micropipette with sterile tips. Plates were incubated for 48 hrs at 37 degrees centigrade. Then agar plates without the culture but with wells containing 30μl fresh juices were also prepared as a negative control to confirm that the juices as well as the plates were free of contamination. Sodium hypochlorite was taken as a positive control. were also prepared as a negative control to confirm that the juices as well as the plates were free of contamination. Sodium hypochlorite was taken as a positive control. Result: results were calculated by measuring the zones of inhibition in mm. using a transparent ruler which were: P. emblica: 29mmZ. officinale:RA. cepa: 23mmSodium hypochlorite:25mm Further study is being conducted to prove it statistically by altering the volume of the various juices used. This study can open up new pathways in search of herbal alternatives that can be used against E faecalis that is known to cause endodontic treatment failure.
A finite size pencil beam algorithm for IMRT dose optimization: density corrections (2007)

For beamlet-based IMRT optimization, fast and less accurate dose computation algorithms are frequently used, while more accurate algorithms are needed to recompute the final dose for verification. In order to speed up the optimization process and ensure close proximity between dose in optimization and verification, proper consideration of dose gradients and tissue inhomogeneity effects should be ensured at every stage of the optimization. Due to their speed, pencil beam algorithms are often used for precalculation of beamlet dose distributions in IMRT treatment planning systems. However, accounting for tissue heterogeneities with these models requires the use of approximate rescaling methods. Recently, a finite size pencil beam (fsPB) algorithm, based on a simple and small set of data, was proposed which was specifically designed for the purpose of dose pre-computation in beamlet-based IMRT. The present work describes the incorporation of 3D density corrections, based on Monte Carlo simulations in heterogeneous phantoms, into this method improving the algorithm accuracy in inhomogeneous geometries while keeping its original speed and simplicity of commissioning. The algorithm affords the full accuracy of 3D density corrections at every stage of the optimization, hence providing the means for density related fluence modulation like penumbra shaping at field edges.
Investigation on Interleaved Boost Converters and Applications (2009)

With the rapid evolving IT technologies, today, the power factor correction (PFC) design is facing many challenges, such as power scalability, high entire-load-range efficiency, and high power density. Power scalability is a very desirable and cost-effective approach in the PFC design in order to keep up with servers ’ growing power requirements. Higher power density can eventually reduce the converter cost and allows for accommodating more equipment in the existing infrastructures. Driven strongly by economic and environmental concerns, high entire-load-range efficiency is more and more required by various organizations and programs, such as the U.S. Energy Star, Climate Savers, and German Blue Angel. Today, the existing boost PFC is reaching its limitations to meet these challenges simultaneously. Using the cutting-edge semiconductor devices, further efficiency improvement at light load is still needed. There are limited approaches available for increasing the power density due to the large EMI filter and inductor size. Interleaved multi-channel boost PFC is a promising candidate to meet those challenges, but the interleaved boost converter is a less explored area. On the other hand, the multi-channel interleaved buck converter for the VR application has been intensively
Principals of functioning of two-channel analysing system (2008)

The structure of the two-channel difference analyzing system is presented for monitoring of environment, the algorithm of its functioning is considered and the adaptive algorithm of work of the system and algorithm of its teaching is proposed.
9) Notizen über die Hydrazine; (1887)

Reduction des Phenylh?ydraziris.Die gewcihnlichen aromatischen Azo-uiid Hydrazokiirper werden bekanntlicli durch nascenten Wasserstoff unter Lbsung der Stickstoffbindung in zwei Amidoproducte gcspalten ").Eine lihnliche Reduction habe icti friiher bei einigen Hydrazinverbindungen beobachtet.So zerfallt das Triathylazoniumjodid
Lipid tear deficiency in persistent dry eye after laser in situ keratomileusis and treatment results of new eye-warming device (2005)

Persistent nature of dry eye after LASIK is attributed to in part to delayed tear clearance, undercorrected aqueous tear deficiency, and nonrecognized lipid tear deficiency.
Downstairs with David Laris:乐享食趣新空间 (2010)

上海,一座堪称中国最精致的城市,所有的餐厅酒店在他的熏陶下都变得无比魅惑,街边的咖啡馆沾染了上海的小资气质都一下子文雅起来。张爱玲曾经形容上海女人说:如果湘粤一带深目削颊的美人是糖醋排骨,上海女人就是粉蒸肉。粉糯中透出无限的遐想,是上海的气质。在上海充满创意遐想的餐厅比比皆是,但是能将这种遐想落到现实的却不多见,Downstairs with David Laris将环保和时尚熔为一炉,呈现精致的美食空间,让食客错以为来的不是餐厅,而是一座充满装修实践意味的艺术展区。
The epidemiology of atopic dermatitis at a tertiary referral skin center in Singapore. (1999)

Atopic dermatitis is a common chronic, relapsing, pruritic ecematous skin condition with a predilection for the flexural areas and occurs in patients with a personal or family history of atopy. The aim of this study is to describe the profile of atopic dermatitis seen at the National Skin Centre in Singapore. A retrospective chart review was conducted of all the patients with atopic dermatitis seen during the first six months of 1994. There were 492 patients whose ages ranged from one month to 74 years with an equal sex ratio. The prevalence was 2%. The onset of the disease occurred before the age of 10 years in 61.2% of patients. In 13.6% of the patients, the onset was after the age of 21 years. Two hundred and fifty-four patients (52%) had "pure" atopic dermatitis without concomitant respiratory allergies. Two hundred and thirty-eight patients (48%) suffered from a "mixed" type, with 23% having allergic rhinitis, 12% having asthma and 13% having both asthma and allergic rhinitis. Two hundred and thirty-one patients (47%) had at least one first-degree family member with atropy: atopic dermatitis (17%), asthma (15%) and allergic rhinitis (15%). Most of the patients, 416 (84.5%), had subacute eczema at presentation. Ichthyosis vulgaris was present in 38 patients (8%) and pityriasis alba in 13 patients (3%). The most common infective complication was bacterial infection (impetiginized eczema, folliculitis, cellullitis) present in 95 patients (19%) followed by viral infections (eczema herpeticum, viral warts and molluscum contagiosum) in 17 patients (3%). Allergies were noted in 43 patients (9%) based on the history given. The most common was drug allergies (penicillin and co-trimoxazole) in 28 patients followed by food allergies in 11 patients. Common aggravating factors reported include heat, sweating, stress, thick clothing and grass intolerance. Most patients could be controlled with a fairly simple regimen of moisturizers, topical steroids and antibiotics for acute flares. Short courses of systemic steroids were used in 78 patients (16%). Three patients were treated with phototherapy, Two on UVAB and one on PUVA. The pattern of atopic dermatitis in Singapore is similar to that reported in the Western literature except for a lower prevalence and a significant proportion of adult onset atopic dermatitis.
QFD 와 QBD 를 이용한 고객만족 전략 수립 절차에 관한 연구 (2001)

고객의 충성도를 높이기 위해서는 고객만족경영을 지속적으로 하여야 한다. 고객만족을 위한 전력 수립에 있어 고객은 가장 중요한 고려사항으로 고객의 의견이 효과적으로 반영이 되어야 한다. 고객의 의견을 효과적으로 추출하기 위한 한 방법은 적절한 설문의 구성을 통해 고객의 반응을 분석하고, 경쟁사와의 고객만족 비교를 통해 고객만족 전략을 수립하는 것이다. 이 논문에서는 효과적인 설문을 구성하기 위해 TQM의 네 주체인 고객, 서비스 (혹은 상품), 서비스를 제공하는 설비, 서비스를 제공하는 사람과 서비스 프로세스의 각 단계에 따른 매트릭스를 이용하여 초기 설문을 구성한다. 초기 설문은 DFD의 개념을 이용하여 평가하고 중복된 설문항목은 삭제하거나 빠진 설문은 추가하여 설문을 완성한다. 설문에 대한 고객의 반응을 가지고 QFD를 이용하여 고객만족 정도를 구하고, 경쟁사와의 비교를 통해 고객만족 전략을 수립한다. 이때 전략 수립과정은 QBD의 절차를 따른다. 최종적으로 전략의 슬로건 및 실행가능 방안을 도출한다. 이 논문은 초기 설문 구성에서부터 최종 고객만족 전략을 도출하기까지의 절차에 대해 QFD와 QBD를 결합한 방법론을 제안하고 가상적인 항공사의 예를 이용하여 각 절차를 설명한다.
Nonlinear conjugate gradients algorithm for 2-D magnetotelluric inversion (2001)

Abstract We investigate a new algorithm for computing regularized solutions of the 2-D magnetotelluric inverse problem. The algorithm employs a nonlinear conjugate gradients (NLCG) scheme to minimize an objective function that penalizes data residuals and second spatial derivatives of resistivity. We compare this algorithm theoretically and numerically to two previous algorithms for constructing such “minimum-structure” models: the Gauss-Newton method, which solves a sequence of linearized inverse problems and has been the standard approach to nonlinear inversion in geophysics, and an algorithm due to Mackie and Madden, which solves a sequence of linearized inverse problems incompletely using a (linear) conjugate gradients technique. Numerical experiments involving synthetic and field data indicate that the two algorithms based on conjugate gradients (NLCG and Mackie-Madden) are more efficient than the Gauss-Newton algorithm in terms of both computer memory requirements and CPU time needed to find accurate solutions to problems of realistic size. This owes largely to the fact that the conjugate gradients-based algorithms avoid two computationally intensive tasks that are performed at each step of a Gauss-Newton iteration: calculation of the full Jacobian matrix of the forward modeling operator, and complete solution of a linear system on the model space. The numerical tests also show that the Mackie-Madden algorithm reduces the objective function more quickly than our new NLCG algorithm in the early stages of minimization, but NLCG is more effective in the later computations. To help understand these results, we describe the Mackie-Madden and new NLCG algorithms in detail and couch each as a special case of a more general conjugate gradients scheme for nonlinear inversion.
The crystal structure of saporin SO6 from <i>Saponaria officinalis</i> and its interaction with the ribosome (2000)

The 2.0 A resolution crystal structure of the ribosome inactivating protein saporin (isoform 6) from seeds of Saponaria officinalis is presented. The fold typical of other plant toxins is conserved, despite some differences in the loop regions. The loop between strands beta7 and beta8 in the C-terminal region which spans over the active site cleft appears shorter in saporin, suggesting an easier access to the substrate. Furthermore we investigated the molecular interaction between saporin and the yeast ribosome by differential chemical modifications. A contact surface inside the C-terminal region of saporin has been identified. Structural comparison between saporin and other ribosome inactivating proteins reveals that this region is conserved and represents a peculiar motif involved in ribosome recognition.
EMC Measurements for Spectrum Sharing Between LTE Signals and Radar Receivers (2014)

In response to proposals to introduce new Long Term Evolution (LTE) microcell Citizens Broadband Service (CBS) radio systems into 3550–3650 MHz (3.5 GHz) radio spectrum in the United States, the authors have performed measurements and analysis on effects of LTE interference on the performance of a type of radar receiver that might eventually share spectrum with such systems. LTE and Gaussian noise interference were injected into a radar receiver; Gaussian noise was a proxy for aggregated interference sources and one type of LTE. Interference was injected into a radar receiver so as to appear coincident with synthetic radar targets on the radar’s display. The targets’ baseline (non-interference) probability of detection (Pd) was 90 percent. With interference present, the targets’ Pd was measured and recorded as a function of LTE signal (both on-tuned and off-tuned) and Gaussian noise interference levels. Additional data presented in this report include: the radar receiver’s antenna radiation pattern, RF front end frequency response, IF-stage frequency response, noise figure, and RF overload response up to an input power of -4.6 dBm. A measured LTE emission spectrum is also provided. Using these data, spectrum management personnel can perform electromagnetic compatibility (EMC) analyses for possible future spectrum sharing between LTE transmitters and this type of radar receiver.
Saliency Unified: A Deep Architecture for simultaneous Eye Fixation Prediction and Salient Object Segmentation (2016)

Human eye fixations often correlate with locations of salient objects in the scene. However, only a handful of approaches have attempted to simultaneously address the related aspects of eye fixations and object saliency. In this work, we propose a deep convolutional neural network (CNN) capable of predicting eye fixations and segmenting salient objects in a unified framework. We design the initial network layers, shared between both the tasks, such that they capture the object level semantics and the global contextual aspects of saliency, while the deeper layers of the network address task specific aspects. In addition, our network captures saliency at multiple scales via inception-style convolution blocks. Our network shows a significant improvement over the current state-of-the-art for both eye fixation prediction and salient object segmentation across a number of challenging datasets.
The Pianist (Motion picture) (2002)

We report the case of an 81-year-old man who presented with an intraoperative type III endoleak after treatment with an Endurant endograft for a 60-mm abdominal aortic aneurysm. To our knowledge, this is the first case of a type III endoleak reported with this new device. It was most likely due to a tear in the polyester graft, the cause of which remains speculative. The tear was demonstrated by postoperative angiography, which was more informative than computed tomography. The endoleak was successfully treated by relining with an aorto-uni-iliac device.
Targeted Drug Delivery Using Immunoconjugates (2011)

Antibody-drug conjugates (also known as "immunoconjugates") have only recently entered the arsenal of anticancer drugs, but the number of undergoing clinical trials including them is ever increasing and most therapeutic antibodies are now patented including their potential immunoconjugate derivatives. They typically consist of three components: antibody, linker, and cytotoxin. An antibody or antibody fragment targeted to a tumor-associated antigen acts as a carrier for drug delivery and can be conjugated by cleavable or uncleavable linkers to a variety of effector molecules, either a drug, toxin, radioisotope, enzyme (the latter also used in Antibody-Directed Enzyme Prodrug Therapy), or to drug-containing liposomes or nanoparticles. In this review, we propose a general outline of the field, starting from the diagnostic and clinical applications of this class of molecules. Special attention will be devoted to the principles and issues in molecular design (choice of tumor-associated antigen, critical milestones in antibody development, available alternatives for linkers and effector molecule, and strategies for fusion proteins building) to the importance of antibody affinity modulation to optimize therapeutic effect and the potential of emerging alternative scaffolds. Most of the power of these molecules is to reach high concentrations in the tumor, relatively unaffecting normal cells, although one drawback lies in their short half-life. In this respect, modifications of immunoconjugates, which have shown to strongly influence pharmacokinetics, like glycosylation and PEGylation, will be discussed. Undergoing clinical trials and active patents will be analyzed and problems present in clinical use will be reported.
Regulation of cellular growth by sodium pump activity (1976)

Cellular growth has been found to be directly related to the amount of sodium pumping activity in mouse lymphoblasts (L5178-Y) cultured in varying concentrations of the cardiac glycoside, ouabain. No short-term adaptation (within one generation) occured; i.e., neither growth rate nor (Na+ + K+)-ATPase activity increased in cells cultured for 1-2 days in ouabain. Growth inhibition commenced after two hours, occurring concomitantly with decreased 3H-leucine incorporation into protein. The time course of this inhibition of protein synthesis, measured by leucine incorporation was similar to, but slightly slower than the time course or the dissipation of the sodium gradient. On the other hand, 3H-thymidine incorporation is unaffected by ouabain treatment over the same period. The uptake of 3H-alanine, a neutral amino acid thought to be transported via a Na+-dependent carri-r, was depressed concurrently with the sodium gradient dissipation. It is suggested, therefore, that ouabain inhibition of cellular growth results primarily from the dissipation of the sodium gradient leading to decreased Na+-dependent transport of amino acids (e.g., alanine) and, therefore, decreased protein synthesis, as observed by leucine incorporation. A sensitive and rapid method for determining ouabain inhibition of cell volume regulation is also described, which may prove potentially useful for assaying Na pump activity.
Biosynthesis of phycobilins. 15,16-Dihydrobiliverdin IX alpha is a partially reduced intermediate in the formation of phycobilins from biliverdin IX alpha. (1991)

A partially purified protein fraction from the phycocyanin-containing unicellular rhodophyte, Cyanidium caldarium, reductively transforms biliverdin IX alpha to a violet colored bilin in the presence of NADPH, ferredoxin, and ferredoxin-NADP+ reductase. This bilin has a violin-like absorption spectrum with maxima at 335 and 560 nm in methanolic HCl and at 337, 567, and 603-604 nm in CHCl3. The bilin has been determined to be 15,16-dihydrobiliverdin IX alpha by comparative spectrophotometry and 1H NMR spectroscopy. This product of biliverdin IX alpha reduction is converted enzymatically to phycobilins by further reduction. A general biosynthetic pathway is proposed which accounts for the formation of the phycobilins from biliverdin IX alpha by a two-step reduction process followed by isomerization.
UML Sequence Diagrams (2005)

UML sequence diagrams are a dynamic modeling technique, as are UML communication diagrams. UML sequence diagrams are typically used to
Thermal lattice Boltzmann method for multiphase flows (2018)

An alternative method to simulate heat transport in the multiphase lattice Boltzmann (LB) method is proposed. To solve the energy transport equation when phase boundaries are present, the method of a passive scalar is considerably modified. The internal energy is represented by an additional set of distribution functions, which evolve according to an LB-like equation simulating the transport of a passive scalar. Parasitic heat diffusion near boundaries with a large density gradient is suppressed by using special "pseudoforces" which prevent the spreading of energy. The compression work and heat diffusion are calculated by finite differences. A new method to take into account the latent heat of a phase transition Q(T) is realized. The latent heat is released or absorbed continuously inside a thin transition layer in a certain range of density, ρ_{1}<ρ<ρ_{2}. This allows one to avoid interface tracking. Several tests were carried out concerning all aspects of the processes. It is shown that the Galilean invariance and the scaling of the thermal conduction process hold, as well as the correct dependence of the sound speed on the heat capacity ratio. The method proposed has low scheme diffusion of the internal energy, and it can be applied to modeling a wide range of multiphase flows with heat and mass transfer even for high density ratios of liquid and vapor phases.
Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial (2019)

This study is registered with ClinicalTrials.gov under protocol number NCT00933647.