gebhart/patrepeval huggingface dataset:
A high sucrose, high linoleic acid diet potentiates hypertension in the dahl salt sensitive rat (1999)

Insulin resistance can be induced by diets high in simple carbohydrates or fatty acids. To determine whether these nutrients also affect arterial pressure in genetic models of salt sensitive and salt resistant hypertension, Dahl salt sensitive (S) and salt resistant (R) rats were each fed the following isocaloric diets containing 3% NaCl for 4 weeks (10 rats/group): 1) control; 2) high sucrose (60%); 3) high linoleic acid (LA, provided as 10% safflower oil); and 4) high sucrose plus high LA. Tail systolic blood pressures (SBP) were measured weekly, and at 4 weeks, direct mean arterial pressures (MBP) were measured in conscious animals. Insulin sensitivity was assessed by in vitro uptake of tritiated glucose by adipocytes in response to graded doses of insulin. Weight gain did not differ among groups. High sucrose alone and high LA alone did not affect blood pressure in either strain. However, SBP and MBP were increased (P < .05) by the high sucrose plus high LA diet in Dahl-S but not in Dahl-R rats. Sucrose alone and LA alone decreased (P < .05) insulin sensitivity in Dahl-S and Dahl-R rats. In both strains, sucrose plus LA decreased insulin sensitivity to a greater extent (P < .05) than sucrose alone or LA alone. Thus, the sucrose plus LA diet decreased insulin sensitivity in both Dahl-S and Dahl-R rats, whereas blood pressure was increased only in Dahl-S rats. The phenotype of elevated arterial pressure is influenced both by a genetic-nutrient interaction and by an interaction among specific nutrients resulting in insulin resistance.
Speech Recognition Oriented Vowel Classification Using Temporal Radial Basis Functions (2009)

The recent resurgence of interest in spatio-temporal neural network as speech recognition tool motivates the present investigation. In this paper an approach was developed based on temporal radial basis function "TRBF" looking to many advantages: few parameters, speed convergence and time invariance. This application aims to identify vowels taken from natural speech samples from the Timit corpus of American speech. We report a recognition accuracy of 98.06 percent in training and 90.13 in test on a subset of 6 vowel phonemes, with the possibility to expend the vowel sets in future.
Cytotoxic, Anti-Inflammatory and Adipogenic Effects of Inophyllum D, Calanone, Isocordato-oblongic acid, and Morelloflavone on Cell Lines (2016)

This paper reports in vitro cytotoxic, anti-inflammatory and adipocyte diffentiation with adipogenic effects of coumarins inophyllum D (1) and calanone (2), and a chromanone carboxylic acid namely isocordato-oblongic acid (3) isolated from Calophyllum symingtonianum as well as a biflavonoid morelloflavone (4) isolated from Garcinia prainiana on MCF-7 breast adenocarcinoma RAW 264.7 macrophages and 3T3-L1 preadipocytes cells, respectively. The cytotoxicity study on MCF-7 cell was conducted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Meanwhile, the study of anti-inflammatory effects in RAW 264.7 macrophages and adipogenic effects on 3T3-L1 pre-adipocytes were conducted through nitrite determination assay and induction of adipocyte differentiation, respectively. In the cytotoxicity study, inophyllum D (1) was the only compounds that exhibited significant cytotoxic effect against MCF-7 cell with IC50 of 84 µg/mL. Further, all by inhibiting the compounds have shown anti-inflammatory effects in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages of nitrite concentration with production. In addition, the compounds also exhibited adipogenic effects on 3T3-L1 pre-adipocytes by stimulating lipid formation. Thus, this study may provide significant input in discovery of the potential effects cytotoxic, anti-inflammatory and adipogenic agents.
Experiencia de la impartición de la asignatura "Teoría del Derecho" dentro del proyecto de innovación educativa de la doble titulación Derecho-Administración de Empresas de la Universitat de València (2006)

En el texto se expone la experiencia en la imparticion de la asignatura troncal “Teoria del Derecho” dentro del Proyecto de innovacion educativa de la Doble Titulacion DerechoDireccion y Administracion de Empresas de la Universitat de Valencia durante los cursos 2003-2004 y 2004-2005 (http://www.uv.es/adedch/). La docencia de la asignatura se inserta no solo dentro de un perfil especifico, como es el de la Doble Titulacion, sino tambien dentro de un proyecto de innovacion educativa en el contexto de la convergencia europea. En lo que sigue se explica la metodologia docente utilizada (docencia basada en casos y problemas; aprendizaje cooperativo; evaluacion continuada,...), y la utilizacion de las herramientas de la plataforma Aula Virtual de la Universitat de Valencia (http://pizarra.uv.es) para facilitar el aprendizaje de los alumnos. Tambien se mostraran los resultados obtenidos y la valoracion que los alumnos han realizado del Proyecto.
Trying to capture additionality in Framework Programme 5 - main findings (2005)

This paper describes an attempt to identify additionality in the projects carried out in the European Union's 5th Framework Programme for Research and Technological Development (FP5) in the context of the recent five-year assessment of FP5. It briefly discusses the various meanings of the concept of additionality and the results of a survey among the participants in FP5. Main findings indicated substantial input and behavioural additionality for a majority of participants. On the other hand, the portfolio of projects included a large number of projects with low risk and of a comparably small size. Design of future FPs should take this into account.
Retention of glomerular basement membrane-proteoglycans accompanying loss of anionic site staining in experimental diabetes. (1989)

The occurrence of heparan sulfate proteoglycan anionic site staining in the glomerular basement membranes of healthy and streptozotocin-induced diabetic rats was investigated. After 12 weeks diabetes, a marked loss of staining by ruthenium red was observed, compared with the age-matched controls. However, extraction and quantitation of total proteoglycan from the glomerular basement membrane revealed no significant differences between the two groups, in terms of absolute yield of glycosaminoglycan, when the latter is expressed per glomerulus. Glomerular basement membranes from both groups become thicker in an age-dependent manner, although they do so at a faster rate in the diabetic group, and a higher collagen content is found in the diabetic membrane at 12 weeks. Thus when proteoglycan content is expressed per mass protein, relative decreases are observed in diabetes. Similarly, a relative but not absolute decrease in proteoglycan content was observed in glomerular basement membranes from spontaneously diabetic BB rats with diabetes of 12 weeks duration. Glycosaminoglycans isolated from control and diabetic glomerular basement membrane have similar characteristics on ion exchange chromatography, to each other, and to newly sulfated, intact glomerular proteoglycans labelled in vitro. We conclude that loss of anionic site staining with ruthenium red in early diabetes is not a consequence of absolute loss or undersulfation of heparan sulfate proteoglycan but reflects structural or biochemical changes in the diabetic matrix.
Endocrine Control of the Timing of Endometrial Sensitivity to a Decidual Stimulus (1972)

The duration, dose and temporal interrelationship of three hormonal parameters: estrous (priming) estrogen, progesterone and nidatory estrogen, are concerned in the timing and degree of endometrial sensitivity to an artificial intrauterine decidual stimulus. Following priming by estrous estrogen the uterus is maximally responsive to subsequent treatment with progesterone and nidatory estrogen for a period of about three days starting on the fourth day after the last priming injection. During this time the fine timing is determined by the duration of progesterone and nidatory estrogen. Neither hormone alone is able to induce sensitivity but in combination sensitivity is maximal in three days. This is followed by a period of insensitivity. Progesterone alone induces a partially prepared state which can be held for several days until sensitivity is completed by estrogen.
Procoagulant Behavior and Platelet Microparticle Generation on Nanoporous Alumina (2009)

In the present work, we have investigated platelet microparticle (PMP) generation in whole blood after contact with nanoporous alumina. Alumina membranes with pore sizes of 20 and 200 nm in diameter were incubated with whole blood and the number of PMP in the fluid phase was determined by flow cytometry. The role of the complement system in PMP generation was investigated using an analog of the potent complement inhibitor compstatin. Moreover, the procoagulant activity of the two pore size membranes were compared by measuring thrombin formation. Results indicated that PMP were not present in the fluid phase after whole blood contact with either of the alumina membranes. However, scanning electron microscope micrographs clearly showed the presence of PMP clusters on the 200 nm pore size alumina, while PMP were practically absent on the 20 nm membrane. We probed no influence of complement activation in PMP generation and adhesion and we hypothesize that other specific material-related protein-platelet interactions are taking place. A clear difference in procoagulant activity between the membranes could also be seen, 20 nm alumina showed 100% higher procoagulant activity than 200 nm membrane. By combining surface evaluation and flow cytometry analyses of the fluid phase, we are able to conclude that 200 nm pore size alumina promotes PMP generation and adhesion while the 20 nm membrane does not appreciably cause any release or adhesion of PMP, thus indicating a direct connection between PMP generation and nanoporosity.
Development of appointment scheduling rules for open access scheduling (2006)

In the early 1990s, a new appointment scheduling concept for outpatient clinics, labeled open access scheduling, advanced access scheduling, or same-day scheduling, was introduced to improve quality of healthcare and reduce the cost of healthcare delivery. The concept becomes popular in medical practices nowadays because it addresses two of the six key aims for healthcare quality improvement targeted by Institute of Medicine: timely care and patient-centered care. However, this concept, still under development, is far from mature, and the critical parameters in open access scheduling are still determined by experience rather than quantitative methods. In this research, mathematical models and quantitative procedures are developed to optimize critical parameters in open access scheduling, and the general guidelines to choose appropriate parameters are obtained by investigating the impacts of clinic environmental characteristics on the optimal parameters. The critical parameters optimized include the percentage of open-access appointments, the time horizon of open-access appointments, and a scheduling template for each provider in each clinic session. First, several efficient quantitative procedures are developed to determine the optimal or Pareto optimal percentages of prescheduled and open-access appointments for a provider in a clinic session. Then, by combining tabu search and Ranking and Selection approach, a heuristic procedure is developed to optimally allocate appointment slots to prescheduled and open-access appointments for a provider in a session. Using these procedures, we investigate the impacts of time horizon of open-access appointments and clinic environmental characteristics on the performance of open access scheduling, and then summarize the general guidelines for clinic administrators to choose a best scheduling policy for each provider in each clinic session in the clinics implementing open access scheduling. These quantitative approaches and general guidelines can decrease the probability of failure to implement open access scheduling, and improve the performance of open access scheduling.
Reversibility of renal injury with cholesterol lowering in hyperlipidemic diabetic mice (2010)

Hyperlipidemia is a risk factor for development and progression of diabetic nephropathy. However, it is not known if reduction of hyperlipidemia is protective against progression of disease. The goal of this study was to determine if reduction of hypercholesterolemia could limit progression of diabetic nephropathy. Diabetic and nondiabetic LDL receptor deficient (LDLR(-/-)) mice were fed diets containing either no cholesterol (0%) or high cholesterol (0.12%) for 36 weeks. One group each of diabetic and nondiabetic mice were fed the high-cholesterol diet for 26 weeks then changed to the 0% cholesterol diet for the last 10 weeks. Consumption of the high-cholesterol diet exacerbated the development of diabetic nephropathy with elevations in urine albumin excretion, glomerular and renal hypertrophy, and mesangial matrix expansion. Increased glomerular lipid and apolipoprotein B accumulation was found in diabetic mice that consumed the 0.12% cholesterol diet compared with other groups. However, diabetic mice that changed from the high-cholesterol diet to the 0% cholesterol diet for the last 10 weeks had lower urine albumin excretion and mesangial matrix expansion compared with mice that consumed the 0.12% cholesterol diet throughout. This suggests that hyperlipidemia causes continuous renal injury, and that lowering cholesterol levels by dietary means can improve renal function in diabetic LDLR(-/-) mice.
Human papillomaviruses and cervical carcinoma. (1989)

The question of whether human papillomavirus (HPV) infection causes, or at least contributes to, the development of cervical carcinoma has been a topic of much scrutiny and controversy over the past few years. The sexual mode of transmission of genital HPVs and detection of viral DNA in cervical tumors suggest a causal role at some stage during malignant progression. To some extent it seems that the epidemiological data accumulated so far have served to confuse as much as to clarify the issue, and the distribution of genital HPVs in the general population appears to be more complex than originally anticipated. However, experimental systems that have been used to study HPVs, in particular recent studies utilizing human genital epithelial cells, have provided strong evidence that certain HPV types can cause premalignant changes in these cells. The development of cervical cancer is a multistage process, and HPV infection alone is clearly not sufficient for full malignant transformation. Nevertheless, identification and control of HPV infection may be of critical importance in the diagnosis and treatment of this disease.
Pharmacokinetics and pharmacodynamics of the monoamine oxidase B inhibitor mofegiline assessed during a phase I dose tolerance trial (1995)

The in vivo intestinal metabolism of the CYP3A probe midazolam to its principal metabolite, 1'-hydroxymidazolam, was investigated during surgery in 10 liver transplant recipients. After removal of the diseased liver, five subjects received 2 mg midazolam intraduodenally, and the other five received 1 mg midazolam intravenously. Simultaneous arterial and hepatic portal venous blood samples were collected during the anhepatic phase; collection of arterial samples continued after reperfusion of the donor liver. Midazolam, 1'-hydroxymidazolam, and 1'-hydroxymidazolam glucuronide were measured in plasma. A mass balance approach that considered the net change in midazolam (intravenously) or midazolam and 1'-hydroxymidazolam (intraduodenally) concentrations across the splanchnic vascular bed during the anhepatic phase was used to quantitate the intestinal extraction of midazolam after each route of administration. For the intraduodenal group, the mean fraction of the absorbed midazolam dose that was metabolized on transit through the intestinal mucosa was 0.43 +/- 0.18. For the intravenous group, the mean fraction of midazolam extracted from arterial blood and metabolized during each passage through the splanchnic vascular bed was 0.08 +/- 0.11. Although there was significant intersubject variability, the mean intravenous and intraduodenal extraction fractions were statistically different (p = 0.009). Collectively, these results show that the small intestine contributes significantly to the first-pass oxidative metabolism of midazolam catalyzed by mucosal CYP3A4 and suggest that significant first-pass metabolism may be a general phenomenon for all high-turnover CYP3A4 substrates.
Studies on the role of some synthetic curcuminoid derivatives in the inhibition of tumour specific angiogenesis. (2003)

In this study, some of the synthetic curcuminoid derivatives are analyzed for their anti-angiogenic activity. Intraperitoneal administration of the compounds tetrahydrocurcumin (THC), salicyl curcumin (SC) and curcuminIII (C-III) reduced the number of tumour directed capillaries induced by injecting B16F-10 melanoma cells on the ventral side of C57BL/6 mice. THC (14.5 +/- 2.5 capillaries) and SC (16 +/- 2.5 capillaries) were more significant (P < 0.001) than C-III (19 +/- 1.8 capillaries) compared to the untreated control (30.8 +/- 2.1 capillaries). Treatment with these curcuminoids reduced the serum NO as well as TNF-alpha levels of the angiogenesis-induced animals. In vitro NO and TNF-alpha production by the activated MOs were reduced in a concentration dependent manner by the treatment of the curcuminoid compounds.
P.S. (1888)

P.S. Get access T. A. T. T. A. T. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s7-VI, Issue 133, 14 July 1888, Pages 36–37, https://doi.org/10.1093/nq/s7-VI.133.36h Published: 14 July 1888
Evaluation of a Contact Sensor Skirt for an Anti-Collision Power Wheelchair for Older Adult Nursing Home Residents With Dementia: Safety and Mobility (2011)

We studied an anti-collision power wheelchair's ability to enable safe, independent mobility in nursing home residents with dementia. The device had a contact sensor skirt that compensated for drivers' absent or delayed responses to obstacles. Safety observations were tracked during device use. In six single-subject studies, distances traveled by residents in manual and anti-collision wheelchairs were compared. Two residents could use the device: One resident's mobility and well-being improved; the other thought it was unhelpful. Another resident with potential for use did not like its usability, speed, and appearance. For two other residents, the device did not compensate for decreased initiation, motor planning, and awareness of obstacles above the sensors. Another resident was withdrawn because of verbal aggression. Interviews and focus groups revealed the device's usefulness. Perceptions of safety were mixed. Further work should improve environmental coverage, sensor skirt reliability, and safety; match technology to the needs of a wider range of residents; and enhance usability, functionality, and acceptance.
International Chemical Education, 5: Chemical Education in Eastern Europe (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInternational Chemical Education, 5: Chemical Education in Eastern EuropeLyle C. Hall Cite this: J. Chem. Educ. 1994, 71, 1, 35Publication Date (Print):January 1, 1994Publication History Received3 August 2009Published online1 January 1994Published inissue 1 January 1994https://doi.org/10.1021/ed071p35Request reuse permissionsArticle Views85Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-Alertsclose Get e-Alerts
Intelligent Control Rule for Tractor with Continuously Variable Transmission (2006)

The problem considered in this paper is the design of the control rule for a tractor equipped with continuously variable transmission. In a traditional control system the optimum fuel economy or dynamic performance control rules only reflect the tractor working state, the driver's intention is partially ignored in control system, therefore, their applications are limited in current tractors. To solve this problem, in this paper, an intelligent control rule based on fuzzy inference of driver's intention was proposed, whose aim is to improve tractor dynamic performance under transient operating conditions and fuel economy under steady operating conditions. Using a fuzzy inference engine, the tractor dynamic factor which was introduced to indicate the driver's demand for tractor dynamic performance based on the change and the change rate of accelerator pedal was obtained. According to the tractor dynamic factor the intelligent transient dynamic control rule can be worked out by interpolating between the fuel economy and dynamic performance control rules. After the tractor acceleration process finishes, the transition control rule was adopted to achieve the smooth transition from intelligent transient dynamic rule to steady fuel economy rule. At last, the simulation results showed that the intelligent control rule enable tractors to reach the optimum comprehensive performance. The works above provided a new design method for developing an intelligent tractor equipped with continuously variable transmission
Wafer Inspection with a Laser Scanning Microscope (1986)

The decreasing geometries and increasing die sizes of today's VLSI circuits are demanding ever more stringent controls over particle contamination on semiconductor wafers during their processing. Consequently, there is a need for objective inspection techniques to monitor defects and contaminants on the surface of semiconductor devices. The goals of such an inspection are:
Computer-intensive methods in statistical analysis (1998)

As far back as the late 1970s, the impact of affordable, high-speed computers on the theory and practice of modern statistics was recognized by Efron (1979, 1982). As a result, the bootstrap and other computer-intensive statistical methods (such as subsampling and the jackknife) have been developed extensively since that time and now constitute very powerful (and intuitive) tools to do statistics with. This article provides a readable, self-contained introduction to the bootstrap and jackknife methodology for statistical inference; in particular, the focus is on the derivation of confidence intervals in general situations. A guide to the available bibliography on bootstrap methods is also offered.