gebhart/patrepeval huggingface dataset:
Nuclear translocation of PKM2 modulates astrocyte proliferation via p27 and β-catenin pathway after spinal cord injury (2015)

Aberrant functionality of the cell cycle has been implicated in the pathology of traumatic SCI. Although it has been reported that the expressions of various cell cycle related proteins were altered significantly following SCI, detailed information on the subject remains largely unclear. The embryonic pyruvate kinase M2 (PKM2) is an important metabolic kinase in aerobic glycolysis or the warburg effect, however, its functions in central nervous system (CNS) injury remains elusive. Here we demonstrate that PKM2 was not only significantly upregulated by western blot and immunohistochemistry but certain traumatic stimuli also induced translocation of PKM2 into the nucleus in astrocytes following spinal cord injury (SCI). Furthermore, the expression levels and localization of p-β-catenin, p27, cyclin D1 and PCNA were correlated with PKM2 after SCI. In vitro, we also found that PKM2 co-immunoprecipitation with p-β-catenin and p27 respectively. Knockdown of PKM2 apparently decreased the level of PCNA, cyclinD1, p27 in primary astrocyte cells. Taken together, our findings indicate that nuclear translocation of PKM2 promotes astrocytes proliferation after SCI through modulating cell cycle signaling. These discoveries firstly uncovered the role of PKM2 in spinal cord injury and provided a potential therapeutic target for CNS injury and repair.
Computer-Aided Fault Tree Analysis (1978)

Abstract : Part I of this report discusses a computer-oriented methodology for deriving minimal cut and path set families associated with arbitrary fault trees. Part II describes the use of the Fault Tree Analysis Program (FTAP), an extensive FORTRAN computer package that implements the Part I methodology. An input fault tree to FTAP may specify the system state as any logical function of subsystem or component state variables or complements of these variables. When fault tree logical relations involve complements of state variables, the analyst may instruct FTAP to produce a family of prime implicants, a generalization of the minimal cut set concept. FTAP can also identify certain subsystems associated with the tree as system modules and provide a collection of minimal cut set families that essentially expresses the state of the system as a function of these modules state variables. Another FTAP feature allows a subfamily to be obtained when the family of minimal cut sets of prime implicants is too large to be found in its entirety; this subfamily consists only of sets that are interesting to the analyst in a special sense.
REINDEER: efficient indexing of <i>k</i> -mer presence and abundance in sequencing datasets (2020)

Supplementary data are available at Bioinformatics online.
UWB, Non Dispersive Radiation From the Planarly Fed Leaky Lens Antenna&#x2014; Part 1: Theory and Design (2010)

An efficient directive antenna is described that can be used to realize essentially non dispersive links over extremely large bandwidths. The antenna is a significantly enhanced version of previously proposed Leaky Lens antennas that use a frequency independent leaky slot radiation mechanism. A theoretical breakthrough now allows the use of this mechanism also in the presence of purely planar structures. This step allows the realization of the feed of a leaky lens antenna in a unique planar structure that is then glued to a standard circularly symmetric elliptical dielectric lens, as integrated technology requires in the mm and sub-mm wave domains. The first part of this sequence deals with a theoretical breakthrough, the consequent antenna concept and a description of the basic physical mechanisms inside and outside the lens antenna. It is shown that Leaky Lens antennas have the potential to be used to realize antenna links over bands exceeding a decade with minimal dispersion, high efficiency and high directivity. The second part of this sequence deals with the demonstration of these claims via the measurement of two prototypes.
Adaptive baseband sub-system for TRUST (2002)

A novel software architecture of the baseband sub-system for a software defined radio terminal is presented. The architecture is flexible, such that it can re-configure itself upon the availability of appropriate software. An object-oriented approach is considered, whereby the functionality of a given baseband module can be changed by instantiating appropriate classes. The formulation of baseband classes and their associated attributes is considered. A management entity is assumed to regulate, administer and manage baseband re-configuration. The functionality of this entity, together with the signalling required to perform re-configuration is also described. Whilst this flexible architecture is restricted in its scope to the baseband sub-system, it is conceptually suitable for re-configurable higher layers as well, assuming a conventional modular protocol stack.
Assentamentos e formas organizacionais dos Kaiowá atuais: o caso dos "índios de Corredor" (2014)

O artigo procura identificar e descrever a modalidade de assentamento kaiowa por eles denominada de corredor, caracterizada pela ocupacao de margens de rodovias. Essa modalidade e de desenvolvimento recente, sendo possivel defini-la como uma das respostas adaptativas dessa populacao as profundas transformacoes historicas e econâmicas por que passou Mato Grosso do Sul. A expropriacao da terra pelas frentes de ocupacao agropastoris alterou profundamente as formas de manejo do ambiente e de apropriacao dos recursos nele existentes. Alteraram-setambem as formas organizacionais, e varias estrategias sao colocadas em pratica para assegurar o acesso aos recursos necessarios a producao da existencia material e ao provimento de elementos da cultura material associados a categorias de representacao do grupo etnico em questao.
A New Collapsing Technique for Star Identification Using Sensors with Nonsimultaneous Acquisition Times (1980)

Abstract : A new stellar image mapping technique based on a state transition matrix form of solution for the rotational motion of a satellite is described. This technique allows star hits observed by an on-board sensor over a period of time to be effectively collapsed to an instantaneous photograph. When good rate gyro samples of the angular velocity are available, this collapsing is rigorous.
A very linear noncontact displacement measurement with a hall-element magnetic sensor (1981)

Two very linear methods for noncontact position measurement are described. They are based on a relative movement between a Hall-element magnetic sensor and a constant gradient static magnetic field. One method depends on measuring the radial component of the field along a bar magnet at a definite distance from the axis of symmetry. The linearity achieved is approximately 0.1 percent over 75 percent of the magnet length. In the second method, the sensor measures the axial field between two opposing axially magnetized discs. In both methods the output signal is symmetrically opposite with respect to the travel midpoint.
Structural restriction in bile acids and non-ionic detergents for promotion of heparin absorption from rat gastro-intestinal tract. (1984)

Selected non-ionic surfactants of the polyoxyethylene ether series as well as selected bile acids elicit plasma clearing activity (PC) after oral heparin administration by action on the gastro-intestinal mucosa. Evidence obtained indicates that certain structural characteristics are needed for promoting heparin absorption, since this effect is observed with some but not all non-ionic detergents (cetyl and stearyl ethers but not lauryl) and bile components (deoxycholic, chenodeoxycholic and cholic acids, but not ursodeoxycholic or dehydrocholic acids or lecithin). It is suggested that a specific mechanism of action is involved.
Software Issues In Redundant Sequential Control (1982)

Redundant control systems require more than a single redundant construct to serve the six basic functions of fault tolerance: test, detection, diagnosis, masking, reconfiguration, and recovery. Software usually constitutes or supports one or more such constructs. Additionally, software must be correct, since it is seldom, if ever, protected by redundancy. A redundant sequential control system requires intricate software constructs. The predominant existing software specification and implementation techniques for sequential control are not adequate for the creation of correct software of the complexity required for redundant systems. This complexity is illustrated by an example.
Inter- and intraindividual variation of endotoxin- and β(1 → 3)-glucan-induced cytokine responses in a whole blood assay (2002)

Inflammatory airway responses to bioaerosols and to their active compounds, such as endotoxin and beta(1 --> 3)-glucan, vary between individuals. These differences may be explained by variation in cytokine responsiveness, which can be assessed by in vitro stimulation tests with isolated blood leukocytes or lung macrophages. In large-scale population studies, ex vivo induced cytokine production may also be tested with a more simple 'whole blood assay' (WBA). However, applicability of a WBA to characterize a subject's responsiveness depends largely on its reproducibility. This study was conducted to: 1) assess the within- and between-subject variability in cytokine production in a WBA after stimulation with endotoxin or beta(1 --> 3)-glucan; and 2) to determine under which conditions this test is most discriminating between subjects and most reproducible within subjects. Blood was collected from 14 healthy volunteers, of whom 10 also participated on a second occasion. Each blood sample was used in two WBA tests; the first WBA was initiated two hours and the second 26 hours after venapuncture. The WBA test itself comprised overnight incubation with serial dilutions of endotoxin [lipopolysaccharide (LPS)] and curdlan (a beta(1 --> 3)-glucan), after which blood cell supernatant was collected. Interleukin(IL)-1beta, IL6, IL8 and tumor necrosis factor alpha (TNFalpha) were determined in the supernatant. In all individuals, a dose-dependent production of cytokines was observed for both LPS and curdlan. For all cytokines, variation between subjects was higher than within subjects, and this was most pronounced for IL1beta and IL6. There was moderate-to-high correlation in the induced release of all four cytokines, and between cytokine release induced by LPS or curdlan. Optimal stimulation concentrations were 6.25 and 12.5 ng/mL for endotoxin and 12500 and 25000 ng/mL for curdlan. Cytokine production in WBA initiated 26 hours after venapuncture showed lower between-subject and larger within-subject variance, thus favoring an early initiation of the assay. In conclusion, measuring endotoxin- or glucan-induced cytokine production in a WBA initiated within two hours after venapuncture appears to be an effective method to determine a person's cytokine responsiveness, at least in healthy naive subjects.
Improving Accuracy by Iterated Multiple Particle Filtering (2012)

This paper analyzes and validates an enhanced implementation of the multiple particle filter that improves its accuracy when applied to high dimensional problems. The algorithm combines the divide et impera philosophy of the multiple particle filter, which avoids the collapse of traditional particle filters, with game theory strategies that provide with a powerful tool to improve the performance. The problem of multiple target tracking with received signal strength measurements is addressed and the results show remarkable improvement over both standard particle filtering and multiple particle filtering.
DISCUSSIONS (1960)

DISCUSSIONS Get access C. J. F. WILLIAMS C. J. F. WILLIAMS Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume LXIX, Issue 275, July 1960, Pages 403–405, https://doi.org/10.1093/mind/LXIX.275.403 Published: 01 July 1960
Analysis of Narcotic Analgesic Usage in the Treatment of Postoperative Pain (1983)

We reviewed 526 medical records of surgical patients and interviewed 81 of these patients. We also sent questionnaires to house staff (57 of 97 responded) and nurses (70 of 142 responded) involved in the care of these patients. A substantial number of patients suffered at least moderate pain during the postoperative period despite analgesic medication. Patients received 70% of the maximal ordered analgesic dose in the first 24 hours. Physicians prescribed drugs in doses that were often inadequate and to be given at inflexible intervals. The optimal doses and duration of action of meperidine, as judged by the house staff and nurses, did not agree with the accepted pharmacologic profile of this drug.
Techniques to Control the Electricity Generation in a Series Hybrid Electrical Vehicle (2002)

In a series hybrid electric vehicle (SHEV), an electric generator feeds a dc busbar (containing an electrochemical accumulator), which, in turn, feeds the vehicle traction system. A very important part of the vehicle is its control system that has to maximize the vehicle efficiency, while keeping the emissions within predetermined limits. To attain this goal it can act in two ways: it can switch the electric generator ON or OFF, or when in ON state, it can impose a given power to be delivered. To choose the control actions to perform it needs: an algorithm to understand the behavior of the battery (determine the state-of-charge, maximum power, losses) and an algorithm to make some forecast of the system load (i.e., the power required in the future of the trip, as a function of time). This paper discusses the main problems arising when trying to synthesize the control system of the vehicle, keeping into particular account the second two issues. Some lab tests are also presented, in which some of the proposed controlled techniques are experimentally checked.
Force/Position Hybrid Control of 6PUS-UPU Redundant Driven Parallel Manipulator Based on 2-DOF Internal Model Control (2014)

To improve control performance of parallel manipulator, servo control is optimized according to 2-DOF control with Internal Model Control. Position loop of the controller is redesigned based on the original current loop and speed loop. The hybrid force/position control strategy on the basis of cross-coupling is proposed. With mechatronic cosimulation system, it is proved that the force/position hybrid control on the basis of 2-DOF Internal Model Control has better stability and position precision compared with the traditional PID control. The control precision and stability of the parallel manipulator are improved effectively in actual experiment. Two types of compliance operation including peg in hole and surface tracking are realized in 6PUS-UPU parallel manipulator and both have good applicable effect.
Fabrication of alginate–gelatin crosslinked hydrogel microcapsules and evaluation of the microstructure and physico-chemical properties (2013)

Microencapsulation of cells by using biodegradable hydrogels offers numerous attractive features for a variety of biomedical applications including tissue engineering. This study highlights the fabrication of microcapsules from an alginate-gelatin crosslinked hydrogel (ADA-GEL) and presents the evaluation of the physico-chemical properties of the new microcapsules which are relevant for designing suitable microcapsules for tissue engineering. Alginate di-aldehyde (ADA) was synthesized by periodate oxidation of alginate which facilitates crosslinking with gelatin through Schiff's base formation between the free amino groups of gelatin and the available aldehyde groups of ADA. Formation of Schiff's base in ADA-GEL and aldehyde groups in ADA was confirmed by FTIR and NMR spectroscopy, respectively. Thermal degradation behavior of films and microcapsules fabricated from alginate, ADA and ADA-GEL was dependent on the hydrogel composition. The gelation time of ADA-GEL was found to decrease with increasing gelatin content. The swelling ratio of ADA-GEL microcapsules of all compositions was significantly decreased, whereas the degradability was found to increase with the increase of gelatin ratio. The surface morphology of the ADA-GEL microcapsules was totally different from that of alginate and ADA microcapsules, observed by SEM. Two different buffer solutions (with and without calcium salt) have an influence on the stability of microcapsules which had a significant effect on the gelatin release profile of ADA-GEL microcapsules in these two buffer solutions.
Introduction (2001)

One of the longest running and least conclusive debates in modern Japan centres on the question of to what degree the Japanese people can or should engage with the outside world. In the background to this debate is the historical fact that, between the 1630s and 1850s, Japan's diplomatic policy was one of near-complete isolation; the only foreigners allowed into the country were Dutch merchants on a trading post at the very southern tip of the islands, some private Chinese traders, and an occasional Korean emissary. Japanese were forbidden on pain of death from travelling overseas. Under overt intimidation from the Western imperial powers, however, this policy was abandoned from the 1860s in favour of importing foreign models of politics, industry, education, law, and military organisation amongst other things: Japanese students and study groups began to roam the globe in search of what was then called 'civilisation and enlightenment'. Over the next century, this revolution in contact with the outside led to extreme fluctuations within Japan between cultural nationalism and internationalism. In general, the staccato rhythm of these fluctuations was dictated by Japan's own military or economic strength. In the 1980s, for example, the apparent 'economic miracle' of the previous twenty years resulted in a flood of books and articles ascribing Japan's success to its village-style social structure and values in which homogeneity of language, custom and thought produced what in an earlier age would have been praised as voluntary organic solidarity but which, in the mind of Japan's critics, looked far more like mechanical regimentation.KeywordsCoffee PlantationJapanese PeopleMigrant CommunityMilitary OrganisationNationalistic PolicyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Effect of the Molding Conditions on Formability in Progressive Glass Molding Press (2009)

Remarkable progress had been made in both technology and production of optical elements including aspheric lens. In the past, precision optical glass lenses were produced through multiple processes such as grinding and polishing, but mass production of aspheric lenses requiring high accuracy and having complex profile was rather difficult. Against such a background, the high-precision optical GMP process was developed with an eye on mass production of precision optical glass pasts by molding press. This GMP process can produce with precision and good repeatability special form lenses such as for cameras, video cameras, aspheric lenses for optical items. In this study, Design Of Experiment(Taguchi method) was adopted to find a tendency of molding conditions that influence formability. Three main factors for molding conditions were selected based on pressure at pressing stage and temperature, pressure at cooling stage. Also, the DOE was carried out and the interference patterns were measured to evaluate the formability of GMP process. From the results, it was found that the cooling pressure is the most sensitive parameter for progressive GMP process.
P‐134: Novel Pixel Compensation Circuit for AMOLED Display (2005)

Abstract A novel pixel circuit for active‐matrix OLED has been developed and simulated. The circuitry is voltage‐driven which compensates not only the threshold voltage (V th ) for TFT device but also the power voltage (PV dd ) for OLED. In this scheme, only one capacitor (C st ) is required to store the V th of the driving TFT as well as to hold the data during one frame time. The voltage drop of PV dd due to large current flown on the power line can also be cancelled out, which improves the uniformity of the brightness. The circuit operation and simulation results will be described and presented.
Multiple system atrophy: clinical presentation and diagnosis. (1999)

Multiple system atrophy (MSA) describes a relatively uncommon, debilitating disorder that is frequently misdiagnosed as Parkinson's disease. Patients with MSA show various combinations of parkinsonism, cerebellar ataxia, pyramidal signs and progressive autonomic failure, especially cardiovascular and urologic autonomic dysfunction. Few treatment options exist. Although some patients initially respond well to dopaminergic treatment for their parkinsonian symptoms, striatal degeneration occurs, and levodopa often becomes ineffective. Thus, physicians may provide only symptomatic treatment and support for patients with MSA. In this paper, we present a case study of a 68-year-old woman who came to the Vanderbilt Movement Disorders Clinic with severe autonomic dysfunction and parkinsonism, previously diagnosed as Parkinson's disease. Following autonomic function tests as well as clinical evaluation, she was diagnosed with MSA and began treatment for orthostatic hypotension and micturition dysfunction.
Pulmonary Dysfunction Related to Immobility in the Trauma Patient (1995)

Immobility is associated with multisystem pathophysiologic sequelae, especially in the critically ill trauma patient. Pulmonary embolus from deep vein thrombosis and nosocomial pneumonia are causes of pulmonary dysfunction that are directly related to immobilization in this population. Because of the high incidence of these complications, early identification of those at risk and institution of aggressive interventions to prevent nosocomial pneumonia and pulmonary embolus are crucial responsibilities of nurses caring for severely injured patients.
Optic Disc Segmentation from Retinal Fundus Images via Deep Object Detection Networks (2018)

Accurate optic disc (OD) segmentation is a fundamental step in computer-aided ocular disease diagnosis. In this paper, we propose a new pipeline to segment OD from retinal fundus images based on deep object detection networks. The fundus image segmentation problem is redefined as a relatively more straightforward object detection task. This then allows us to determine the OD boundary simply by transforming the predicted bounding box into a vertical and non-rotated ellipse. Using Faster R-CNN as the object detector, our method achieves state-of-the-art OD segmentation results on ORIGA dataset, outperforming existing methods in this field.
Paclitaxel Inhibits Proliferation of Cell Lines Responsible for Metal Stent Obstruction: (2002)

Paclitaxel incubation resulted in a dose dependent inhibition of cell proliferation of human epithelial gallbladder cells, human fibroblasts and pancreatic carcinoma cells. This inhibitory effect of paclitaxel on the cell lines could serve as the basis to develop drug coated or drug eluting stents for malignant biliary strictures.