gebhart/patrepeval huggingface dataset:
Requirements for the industrial automation of compact thermal model creation using CFD simulation (2014)

The generation of Compact Thermal Models (CTMs) for electronics packages with simulation tools has long been a task for thermal engineers. One of the challenges traditionally associated with this task is the engineering effort required to reliably create a high quality detailed simulation model of a package family and any design variants in a consistent manner. Implementation of an automated methodology to produce CTMs would introduce much efficiency to this process, freeing up valuable engineering expertise for higher value activities within the organization. Achieving such an automated workflow has however several pre-requisites. These are introduced and discussed in this paper, and illustrated by way of a case study.
A 1‐Methyl‐Phosphininium Compound: Synthesis, X‐Ray Crystal Structure, and DFT Calculations (2003)

Ein vierbindiges Phosphoratom in einem aromatischen System! Ein 1-Methylphosphininiumtetrachlorogallat wurde synthetisiert und vollständig charakterisiert (siehe Struktur). Seine aromatischen Eigenschaften ähneln denen von Phosphinin, Pyridin und Pyridiniumsalzen. Diese Merkmale wurden durch DFT-Rechnungen bestätigt und quantifiziert. Das Phosphininiumsalz reagiert leicht mit einem Alkin in einer Diels-Alder-Reaktion zu einem Phosphabarelleniumsalz. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2003/z52230_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Isothermal and anisothermal 3D behavior of shape memory alloys (2005)

September 5-8
SEDIMENT TRANSPORT THEORIES. (1975)

Keywords HYDRAULICS RESEARCH STATION, LABORATORIO DE HIDRAULICA APLICADA, BUENOS AIRES SEDIMENTS, METHODS, RESEARCH, DATA, WATER, FLUIDS, TOTAL, TRANSPORT, RATES, FLUMES, SAND, CHANNELS, PERFORMANCE, EXPERIMENTS, THEORY, HYDRAULICS, FIELD, MATERIALS, PARTICLES, LOADS... Show All
Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring (2000)

Human and murine infection with Trypanosoma cruzi parasite is usually accompanied by strong humoral and cellular immune response to cruzipain, a parasite immunodominant antigen. In the present study we report that the immunization of mice with cruzipain devoid of enzymatic activity, was able to induce antibodies which bind to a 223-kDa antigen from a mouse heart extract. We identified this protein as the mouse cardiac myosin heavy chain by sequencing analysis. The study of IgG isotype profile revealed the occurrence of all IgG isotypes against cruzipain and myosin. IgG1 showed the strongest reactivity against cruzipain, whereas IgG2a was the main isotype against myosin. Anti-cruzipain antibodies purified by immunoabsorption recognized the cardiac myosin heavy chain, suggesting cross-reactive epitopes between cruzipain and myosin. Autoimmune response in mice immunized with cruzipain was associated to heart conduction disturbances. In addition, ultrastructural findings revealed severe alterations of cardiomyocytes and IgG deposit on heart tissue of immunized mice. We investigated whether antibodies induced by cruzipain transferred from immunized mothers to their offsprings could alter the heart function in the pups. All IgG isotypes against cruzipain derived from transplacental crossing were detected in pups' sera. Electrocardiographic studies performed in the offsprings born to immunized mothers revealed conduction abnormalities. These results provide strong evidence for a pathogenic role of autoimmune response induced by a purified T. cruzi antigen in the development of experimental Chagas' disease.
Perspectives de developpements technologiques dans la filiere des industries des cereales (1990)

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Significance of serum enzyme changes after cardiac catheterization and selective coronary arteriography. (1976)

The serum creatine kinase (CK), aspartate transaminase (AST), lactic dehydrogenase (LD) and alpha-hydroxybutyric dehydrogenase (HBD) were determined before and 3, 6, 18, and 36 hours after cardiac catheterization and angiocardiography in 56 consecutive patients with ischaemic heart disease. Five of these patients whose serum enzyme levels were higher than normal before the procedure were excluded from the study. Forty-one of the remaining 51 patients had left ventriculography and also selective coronary arteriography. In these 41 patients (groups 1 and 2--see below), the mean serum CK levels increased after the procedure to exceed the upper limit of normal at every study interval. The mean serum AST, LD, and HBD levels generally remained within the normal range at all study intervals, though serum AST increased abnormally in 9 of the 41 patients (22%) and serum LD and HBD each increased above the normal limit in 2 of 41 patients (4.9%). In 24 patients (group 1) whose coronary arteriograms showed insignificant coronary narrowing (less than 75%) in any of the three major coronary arteries, the increase in serum CK was significantly higher than in 17 patients (group 2) with greater than 75% narrowings in at least one of the three major coronary arteries. However, the degree of serum CK elevation observed during the postangiographic period was much lower than that in another group of 30 consecutive patients with acute myocardial infarction. In 10 patients (group 3) who had the same procedure as groups 1 and 2 except without the selective coronary arteriography, the serum enzyme levels showed no noticeable increase after the procedure. The difference in postangiographic serum CK elevation between patients with and without selective coronary arteriography and the difference between group 1 (without significant coronory narrowing) and group 2 (with significant narrowing) strongly suggest that the raised serum CK levels represent some form of myocardial damage caused by the coronary arteriography, which, however, is different at least in degree from that of acute myocardial infarction.
“Vinylogs” and “Acetylenylogs” of β‐Adrenergic Agents (1996)

Vinylogous (Groups III and V) and acetylenologous (Group IV) analogs of the classical beta-adrenergic agents--stimulants and blockers--were prepared in order to evaluate the effect of degree of saturation, position of unsaturation and rigidity of the chain linking the aromatic ring and the amino containing functional group on biological activity. Derivatives from Group III, which represent 4-aryl-3-butenyl-2-ol-amine analogs of Group II, retained beta 1-adrenoceptor antagonist activity albeit substantially less potent (50-200-fold) than that possessed by their aryloxy counterparts. Consistent with the SAR for Group II compounds, substitution at position 2 of the aromatic ring yielded the most potent antagonists (5a, 5d, 5g), with KB's ranging from 73-93 nM while 3,4-dichloro substitution (5e) markedly reduced antagonist potency (KB = 2,400 nM). Agonist activity was also noted for 5b and 5d, suggesting that these compounds may be best classified as partial agonists. Representatives from Groups IV and V were inactive as antagonists at the beta 1-adrenoceptor confirming the importance of the spatial relationship between the hydroxyl and the amino nitrogen.
Specific muscle identities are regulated by <i>Krüppel</i> during <i>Drosophila</i> embryogenesis (1997)

During Drosophila embryogenesis, mesodermal cells are recruited to form a complex pattern of larval muscles. The formation of the pattern is initiated by the segregation of a special class of founder myoblasts. Single founders fuse with neighbouring nonfounder myoblasts to form the precursors of individual muscles. Founders and the muscles that they give rise to have specific patterns of gene expression and it has been suggested that it is the expression of these founder cell genes that determines individual muscle attributes such as size, shape, insertion sites and innervation. We find that the segmentation gene Krüppel is expressed in a subset of founders and muscles, regulates specific patterns of gene expression in these cells and is required for the acquisition of proper muscle identity. We show that gain and loss of Krüppel expression in sibling founder cells is sufficient to switch these cells, and the muscles that they give rise to, between alternative cell fates.
The Integrated Structureless Electrodynamic Propulsion (ISEP) Experiment (2007)

The objective of the Integrated Structural Electrodynamic Propulsion (ISEP) Experiment is to demonstrate the ability of multi-functional conductive structures to generate thrust and torque on a spacecraft system. The ISEP experiment will deploy several lightweight, conducting structures nominally 10 meters in length from a CubeSat and demonstrate generation of electrodynamic thrust and torque by driving currents along these booms. To affect current closure to the plasma, a combination of field emissive array cathodes (FEACs) along with simple lightweight, compact electron collectors, and miniature plasma contactors will be used to drive up to 1 ampere of current through the booms. The goal is to generate current flow through the conductors in such a way as to produce measurable thrust and torque on the host spacecraft, further validating the proposed concept. The data obtained on plasma contactor performance and electrodynamic thrust will validate the feasibility of the ISEP concept and provide crucial guidance on how to design future space systems incorporating structures with integrated electrodynamic (ED) propulsion. These results will also be of benefit to missions and concepts that utilize electrodynamic propulsion ranging from ED tether deorbit systems, ED drag makeup tether systems, as well as systems requiring efficient plasma contactors such as traditional electric propulsion and spacecraft charging subsystems.
The influence of age on the take-over of vehicle control in highly automated driving (2017)

The growing proportion of older drivers in the population plays an increasingly relevant role in road traffic that is currently awaiting the introduction of automated vehicles. In this study, it was investigated how older drivers (⩾60 years) compared to younger drivers (⩽28 years) perform in a critical traffic event when driving highly automated. Conditions of the take-over situation were manipulated by adding a verbal non-driving task (20 questions task) and by variation of traffic density. Two age groups consisting of 36 younger and 36 older drivers drove either with or without a non-driving task on a six-lane highway. They encountered three situations with either no, medium or high traffic density where they had to regain vehicle control and evade an obstacle on the road. Older drivers reacted as fast as younger drivers, however, they differed in their modus operandi as they braked more often and more strongly and maintained a higher time-to-collision (TTC). Deterioration of take-over time and quality caused by increased traffic density and engagement in a non-driving task was on the same level for both age groups. Independent of the traffic density, there was a learning effect for both younger and older drivers in a way that the take-over time decreased, minimum TTC increased and maximum lateral acceleration decreased between the first and the last situation of the experiment. Results highlight that older drivers are able to solve critical traffic events as well as younger drivers, yet their modus operandi differs. Nevertheless, both age groups adapt to the experience of take-over situations in the same way.
Experimental investigation of linear resonant bubble behavior between parallel plates (2006)

Recent findings suggest that bubble clouds play an active role in the breakup of kidney stones in patients undergoing shock-wave lithotripsy treatment. Understanding the dynamic behavior of the bubble cloud and its component bubbles within confined spaces will increase the efficacy of the treatment, but to date, even idealized model systems are not well understood. The behavior of a single bubble near a rigid plane has been verified; the study of this configuration is one of a bubble and a single bubble image source. A model recently set forth [Cui et al., J. Acoust. Soc. Am. 119 (in press)] gives a description of the dynamics of a bubble between rigid parallel planes by using an infinite string of bubble image sources. This represents a step toward understanding the dynamics of fully enclosed bubble clouds. Experimental measurements of the resonance frequency and quality factor of air bubbles suspended between two parallel stainless-steel plates are presented and compared to the new model. An acoustic spectral subtraction technique was used to isolate the bubble response from that of the experimental tank. The bubbles were independently sized using diffuse backlighting and video microscopy. [Work supported by ARL:UT.]
Urinary Stone Risk Factors in the Siblings of Patients With Calcium Renal Stones (2002)

Select urinary measurements as well as age classify siblings into those with and without stones with fair accuracy. Calcium excretion and urinary pH in females, and calcium excretion, urinary potassium and age in males are feasible identifiers of stone forming siblings. To determine whether these measurements can be used to predict new stone onset may require years of observation of our current cohort.
A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke (2013)

With the availability and ease of small molecule production and design continuing to improve, robust, high-throughput methods for screening are increasingly necessary to find pharmacologically relevant compounds amongst the masses of potential candidates. Here, we demonstrate that a primary oxygen glucose deprivation assay in primary cortical neurons followed by secondary assays (i.e. post-treatment protocol in organotypic hippocampal slice cultures and cortical neurons) can be used as a robust screen to identify neuroprotective compounds with potential therapeutic efficacy. In our screen about 50% of the compounds in a library of pharmacologically active compounds displayed some degree of neuroprotective activity if tested in a pre-treatment toxicity assay but just a few of these compounds, including Carbenoxolone, remained active when tested in a post-treatment protocol. When further examined, Carbenoxolone also led to a significant reduction in infarction size and neuronal damage in the ischemic penumbra when administered six hours post middle cerebral artery occlusion in rats. Pharmacological testing of Carbenoxolone-related compounds, acting by inhibition of 11-β-hydroxysteroid dehydrogenase-1 (11β-HSD1), gave rise to similarly potent in vivo neuroprotection. This indicates that the increase of intracellular glucocorticoid levels mediated by 11β-HSD1 may be involved in the mechanism that exacerbates ischemic neuronal cell death, and inhibiting this enzyme could have potential therapeutic value for neuroprotective therapies in ischemic stroke and other neurodegenerative disorders associated with neuronal injury.
Cell Turgor Changes Associated with Ripening in Tomato Pericarp Tissue (1991)

The pressure microprobe was used to determine whether the turgor pressure in tomato (Lycopersicon esculentum Mill., variety "Castelmart") pericarp cells changed during fruit ripening. The turgor pressure of cells located 200 to 500 micrometers below the fruit epidermis was uniform within the same tissue (typically +/- 0.02 megapascals), and the highest turgors observed (<0.2 megapascals) were much less than expected, based on tissue osmotic potential (-0.6 to -0.7 megapascals). These low turgor values may indicate the presence of apoplastic solutes. In both intact fruit and cultured discs of pericarp tissue, a small increase in turgor preceded the onset of ripening, and a decrease in turgor occurred during ripening. Differences in the turgor of individual intact fruit occurred 2 to 4 days before parallel differences in their ripening behavior were apparent, indicating that changes in turgor may reflect physiological changes at the cell level that precede expression of ripening at the tissue level.
The history of Belgian assisted reproduction technology cycle registration and control: a case study in reducing the incidence of multiple pregnancy (2013)

No external funding was sought for this study. None of the authors has any conflict of interest to declare.
Inadequate control of heart rate in patients with stable angina: results from the European Heart Survey (2010)

Control of ischaemic symptoms through heart rate modification in patients with angina is currently inadequate, both by primary referring physicians and cardiologists. Given the adverse outcome associated with higher resting heart rates in this as in other studies, and the availability of specific HR reducing strategies, attention should be given to achieving optimal HR control.
Secondary amyloidosis: a severe complication of ankylosing spondylitis. Two case-reports. (2000)

Secondary amyloidosis is a rare complication of ankylosing spondylitis that can cause severe renal and gastrointestinal complications. No treatment capable of clearing established amyloid deposits is available to date.
IC‐P‐082: Differences in MRI measures of brain volume, white matter hyperintensities and infarcts in Chinese: The Shanghai Community Brain Health Initiative (SCOBHI) (2009)

China is a nation with the potential for 300 million elders over 65 by the year 2030 at risk for dementia, but the etiology of dementia in China has been understudied. We conducted a pilot study of 26 normal controls, 26 MCI and 43 dementia cases in Shanghai, China between May and November 2008. Cases were those presenting to the Memory Disorders Clinic at Huashan Hospital who were diagnosed per study protocol with dementia or Mild Cognitive Impairment by standard clinical criteria. Controls were recruited from the Jing An community by door-to-door approach. MRI imaging was performed in China and the data transferred to UCD for analysis. 95 subjects were included in this analysis (average age: 75 ± 5.22), 52% female with 26 normal elderly (average age: 73.96 ± 5.83). Brain volume and white matter hyperintensities (WMH) were measured from the FLAIR and two expert raters rated MR infarcts. There we no significant group differences by age, gender or education. Brain and WMH volumes were significantly different by diagnosis (p < 0.0001 and 0.0005 respectively) with 4% difference in brain and 15% in WMH volumes. The prevalence of MRI infarcts was increased in dementia versus normal and MCI (53%, 30% and 31%, respectively, p = 0.025). Cortical infarcts were rare (5% prevalence) with no cortical infarcts identified in normals, and 5% and 9% of MCI and demented, respectively. The prevalence of subcortical infarcts also was increased in dementia versus normal and MCI (37%, 22%, 19% respectively; p = 0.01). Finally, age, diagnosis and MRI infarcts were associated with WMH volumes (p <0.0006), whereas age, diagnosis and WMH volumes were significantly associated with brain volume (p = 0.026). Evidence of cerebrovascular disease and brain atrophy was common in cognitively impaired subjects of the SCOBHI study. Moreover, MRI infarcts were associated with WMH volume and WMH volume was also significantly associated with brain volume, suggesting that the biology of cognitive impairment in SCOBHI likely reflects, in part, the effects of vascular brain injury.
Optical implementation of visible gray-image morphology with the visual-area-coding technique (1996)

We present a novel scheme of visible gray-image morphology with the visual-area-coding technique (VACT). The VACT is a technique of digitized analog-optical computing in which data are converted into visible coded patterns and processed with the visible form. Because the achievable operations in the VACT are identical to those of mathematical morphology, mathematical morphology is adapted to gray-image morphology with the VACT. Computer simulation and optical experiments of the several operations in mathematical morphology verify the correctness of the proposed technique. The processing capacity of the proposed method is estimated in terms of the space-bandwidth product.
Spark decomposition of SF/sub 6//H/sub 2/O mixtures (1989)

The spark decomposition of mixtures of SF/sub 6/ (partial pressure from 100 to 500 kPa) and water (concentrations between 600 and 2000 VPM) has been studied. The sparks were generated between a point (stainless steel) and a plane (aluminum) either under 50-Hz AC voltage or by discharging a capacitor. Owing to the high water content the only stable gaseous oxyfluorides detected were, in order of decreasing importance, SOF/sub 2/ and SO/sub 2/F/sub 2/. The yields of these two byproducts have been measured as a function of the number of sparks, the SF/sub 6/ pressure, and the H/sub 2/O pressure. When the sparks additionally struck a solid insulator (polytetrafluoroethylene or biphenolic resin), CF/sub 4/ was detected. Its appearance was paralleled by a sharp increase in the yield of SOF/sub 2/, whereas that of SO/sub 2/F/sub 2/ remained unchanged.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development of the Next-Generation Caustic-Side Solvent Extraction (NG-CSSX) Process for Cesium Removal from High-Level Tank Waste (2011)

This paper describes the chemical performance of the Next-Generation Caustic-Side Solvent Extraction (NG-CSSX) process in its current state of development for removal of cesium from the alkaline high-level tank wastes at the Savannah River Site (SRS) in the US Department of Energy (USDOE) complex. Overall, motivation for seeking a major enhancement in performance for the currently deployed CSSX process stems from needs for accelerating the cleanup schedule and reducing the cost of salt-waste disposition. The primary target of the NG-CSSX development campaign in the past year has been to formulate a solvent system and to design a corresponding flowsheet that boosts the performance of the SRS Modular CSSX Unit (MCU) from a current minimum decontamination factor of 12 to 40,000. The chemical approach entails use of a more soluble calixarene-crown ether, called MaxCalix, allowing the attainment of much higher cesium distribution ratios (DCs) on extraction. Concurrently decreasing the Cs-7SB modifier concentration is anticipated to promote better hydraulics. A new stripping chemistry has been devised using a vitrification-friendly aqueous boric acid strip solution and a guanidine suppressor in the solvent, resulting in sharply decreased DCs on stripping. Results are reported herein on solvent phase behavior and batch Cs distribution for wastemore » simulants and real waste together with a preliminary flowsheet applicable for implementation in the MCU. The new solvent will enable MCU to process a much wider range of salt feeds and thereby extend its service lifetime beyond its design life of three years. Other potential benefits of NG-CSSX include increased throughput of the SRS Salt Waste Processing Facility (SWPF), currently under construction, and an alternative modular near-tank application at Hanford.« less