gebhart/patrepeval huggingface dataset:
ViSlang: A System for Interpreted Domain-Specific Languages for Scientific Visualization (2014)

Researchers from many domains use scientific visualization in their daily practice. Existing implementations of algorithms usually come with a graphical user interface (high-level interface), or as software library or source code (low-level interface). In this paper we present a system that integrates domain-specific languages (DSLs) and facilitates the creation of new DSLs. DSLs provide an effective interface for domain scientists avoiding the difficulties involved with low-level interfaces and at the same time offering more flexibility than high-level interfaces. We describe the design and implementation of ViSlang, an interpreted language specifically tailored for scientific visualization. A major contribution of our design is the extensibility of the ViSlang language. Novel DSLs that are tailored to the problems of the domain can be created and integrated into ViSlang. We show that our approach can be added to existing user interfaces to increase the flexibility for expert users on demand, but at the same time does not interfere with the user experience of novice users. To demonstrate the flexibility of our approach we present new DSLs for volume processing, querying and visualization. We report the implementation effort for new DSLs and compare our approach with Matlab and Python implementations in terms of run-time performance.
NCX 4016, a nitric oxide-releasing aspirin derivative, exhibits a significant antiproliferative effect and alters cell cycle progression in human colon adenocarcinoma cell lines (2003)

Nitric oxide-releasing non-steroidal antiinflammatory drugs (NO-NSAIDs) are safer than NSAIDs due to their ability to reduce gastric toxicity. We assessed the cytotoxic activity of a new aspirin derivative, NCX 4016, after different exposure schedules, in three human colon adenocarcinoma cell lines. All the lines were positive for COX-1 protein and mRNA, as evaluated by Western blot and RT-PCR, respectively, while only one was positive for COX-2. The cytostatic and cytocidal activity was determined by sulforhodamine B assay and evaluated according to Monks' model. Cytostatic activity was observed after a 24-h drug exposure and 50% growth inhibition was reached at concentrations ranging from 165 to 250 micro M in all cell lines, whereas with aspirin the IC50 was never reached, even at the maximum concentration tested (500 micro M), and was independent of COX-1 or COX-2 status. Cytocidal activity was observed only at the highest concentrations and persisted for a long time after drug removal. Flow cytometric analysis showed that the NO-aspirin compound induced a persistent accumulation of cells in G2-M phase in all the cell lines after at least 48 h exposure. Specifically, the block pertained mainly to G2 phase, whereas mitotic index was not affected at all. Our results indicate that NCX 4016 has an in vitro cytostatic activity superior to that of its parental aspirin compound, which makes it a potentially important tumor preventive agent. Furthermore, the cytocidal effect observed at the highest concentrations and the induction of a specific block in G2 phase renders it a promising candidate for drug combination treatments.
RNA and Protein Synthesis in Liver of Rats maintained on Vitamin B1-deficient Diet (1969)

1. V. B1欠乏飼料を投与したラットは, はじめ2週間までは体重はやや増加したがその後欠乏日数の経過と共に減少し, 31日では初体重よりも減少した。 しかしV. B1投与によって回復した。2. V. B1欠乏ラットの湿肝重量は欠乏18日までは, わずかに増加するがその後増加は認められなかった。3. 肝細胞におけるV. B1はその大半が細胞質に存在し欠乏日数の経過と共に急速に減少した。4. ポストミトコンドリヤ上清画分のポリソームパターンは, 欠乏18日よりheavy polysomesの減少, lightpolysomesの増加を示し, この傾向は欠乏25日および31日では更に顕著にあらわれ, V. B1投与後は急速に回復した。5. 精製ポリソームパターンにおいては欠乏7日のポリソームは, 対照に対してheavy polysomesの増加の傾向がみられ, 3H-オロチン酸の取り込みもtrimer以上のポリマー部分において増加した。 欠乏25日および31日ではheavy polysomesが減少しlight polysomesの増加が顕著にあらわれ, 3H-オロチン酸の取り込みも極度に減少した。 なおhexamer以上のポリソームの全リボソームに対する割合は, 欠乏7日で一過性の増加を示しその後減少した。6. in vivoにおける3H-オロチン酸のポリソームRNAへの取り込みの比活性, およびin vitroにおける14C-ロイシンの取り込みの比活性は, いずれも欠乏7日に一過性の増加を示し, その後欠乏日数の経過と共に減少した。 またin vivoにおける核RNAへの3H-オロチン酸の取り込みの比活性は欠乏7日で対照よりやや増加しているが大差は示さず, 欠乏18日より減少した。 そしていずれもV. B1投与後は急速に回復した。
First-principles study of tunneling magnetoresistance in Fe/MgAl<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mrow/><mml:mn>2</mml:mn></mml:msub></mml:math>O<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mrow/><mml:mn>4</mml:mn></mml:msub></mml:math>/Fe(001) magnetic tunnel junctions (2012)

We investigated the spin-dependent transport properties of Fe/MgAl${}_{2}$O${}_{4}$/Fe(001) magnetic tunneling junctions (MTJs) on the basis of first-principles calculations of the electronic structures and the ballistic conductance. The calculated tunneling magnetoresistance (TMR) ratio of a Fe/MgAl${}_{2}$O${}_{4}$/Fe(001) MTJ was about 160$%$, which was much smaller than that of a Fe/MgO/Fe(001) MTJ (1600$%$) for the same barrier thickness. However, there was an evanescent state with ${\ensuremath{\Delta}}_{1}$ symmetry in the energy gap around the Fermi level of normal spinel MgAl${}_{2}$O${}_{4}$, indicating the possibility of a large TMR in Fe/MgAl${}_{2}$O${}_{4}$/Fe(001) MTJs. The small TMR ratio of the Fe/MgAl${}_{2}$O${}_{4}$/Fe(001) MTJ was due to new conductive channels in the minority spin states resulting from a band-folding effect in the two-dimensional Brillouin zone of the in-plane wave vector (${k}_{\ensuremath{\parallel}}$) of the Fe electrode. Since the in-plane cell size of MgAl${}_{2}$O${}_{4}$ is twice that of the primitive in-plane cell size of bcc Fe, the bands in the boundary edges are folded, and minority-spin states coupled with the ${\ensuremath{\Delta}}_{1}$ evanescent state in the MgAl${}_{2}$O${}_{4}$ barrier appear at ${k}_{\ensuremath{\parallel}}=0$, which reduces the TMR ratio of the MTJs significantly.
Design and comparison of an optimized permanent magnet-assisted synchronous reluctance motor (PMa-SynRM) with an induction motor with identical NEMA Frame stators (2009)

The performance of a synchronous reluctance motor (SynRM) depends on the direct axis inductance (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> ) and the quadrature axis inductance (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</sub> ) of the machine. To achieve high torque density and power factor, increasing the saliency ratio L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> /L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</sub> and making the difference of these inductances (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> -L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</sub> ) large enough are well known methods. Otherwise, the performance of the motor will remain below that of a similar induction machine using similar stator. By placing a proper amount of permanent magnets inside of the rotor in proper position it will be possible to achieve a significant improvement in performance of this permanent magnet assisted SynRM (PMa-SynRM) which will be comparable with induction machines with same stators. This PMa-SynRM will have benefit of reduced price due to use of conventional induction machines stators. This study investigates the characteristic of an optimized PMa-SynRM rotor for a specific 36-slot NEMA-Frame stator used in 7.5 HP induction motor and the paper presents the comparison results between the PMa-SynRM, SynRM, and the induction motor obtained from FEM analysis.
Female Goldeneyed Lacewings (Neuroptera: Chrysopidae) Approach but Seldom Enter Traps Baited with the Male-Produced Compound Iridodial (2007)

Earlier, we identified (1R,2S,5R,8R)-iridodial as a male-specific compound of the goldeneyed lacewing, Chrysopa oculata Say (Neuroptera: Chrysopidae), but traps baited with this compound caught almost exclusively males. In the present report, we demonstrated by sweep-net sampling and observation in the vicinity of pheromone lures that C. oculata females, and males, are strongly attracted to iridodial. Aggregation activity of C. oculata adults occurred between dusk and dawn. This research demonstrates that iridodial may be useful to induce goldeneyed lacewings to lay eggs in targeted plant patches for biological pest control.
Clinico-pharmacological aspects of metoprolol use (2013)

Over the years b-blocker metoprolol is one of the commonly prescribed drugs for the treatment of various cardiovascular pathologies . The following review article discusses the classification of b-blockers , and pharmacokinetics of two metoprolol forms available on the market today: metoprolol tartrate (Vasocardin, Corvitolum, Egilok ) and metoprolol succinate (Betaloc ZOK). The role of metoprolol in the treatment of hypertension, coronary artery disease and heart failure is described here as well.
IDENTIFYING MUSCLE REGULATORY ELEMENTS AND GENES IN THE NEMATODE <i>CAENORHABDITIS ELEGANS</i> (2001)

We report the identification of several putative muscle-specific regulatory elements, and genes which are expressed preferentially in the muscle of the nematode Caenorhabditis elegans. We used computational pattern finding methods to identify cis-regulatory motifs from promoter regions of a set of genes known to express preferentially in muscle; each motif describes the potential binding sites for an unknown regulatory factor. The significance and specificity of the identified motifs were evaluated using several different control sequence sets. Using the motifs, we searched the entire C. elegans genome for genes whose promoter regions have a high probability of being bound by the putative regulatory factors. Genes that met this criterion and were not included in our initial set were predicted to be good candidates for muscle expression. Some of these candidates are additional, known muscle expressed genes and several others are shown here to be preferentially expressed in muscle cells by using GFP (green fluorescent protein) constructs. The methods described here can be used to predict the spatial expression pattern of many uncharacterized genes.
Identification of Neisseria gonorrhoeae in Synovial Membrane by Electron Microscopy (1974)

A paucity of information exists regarding the histopathology of early gonococcal arthritis. Synovial tissue from a patient with gonococcal arthritis of two days' duration was examined by light and electron microscopy. Neisseria gonorrhoeae was cultured from synovial fluid but not from the biopsied membrane, although gram-negative diplococci were demonstrated in synovial lining cells. After staining with hematoxylin and eosin, only minimal inflammation limited to margination of polymorphonuclear leukocytes in vessels and hypertrophy of the lining cell layer was visible. Electron microscopy of the tissue showed many organisms in the type A phagocytic lining cells and some in the extracellular spaces. While extracellular organisms appeared to be mainly intact, intracellular organisms demonstrated morphologic variation, with some degraded forms consistent with wall-defective variants. This is the first demonstration of N. gonorrhoeae in synovial tissue by electron microscopy.
Performance evaluation of the simple control transmission protocol (SCTP) (2002)

A new protocol which could be used for the transport of telecommunication signalling messages over an IP-based network is currently being discussed within the IETF. The protocol is called stream control transmission protocol (SCTP). We describe SCTP and an implementation of SCTP. Furthermore, we evaluate how the protocol performs in a wide area network, especially when competing with TCP. The results were obtained in a test-bed consisting of two local networks which are interconnected via an emulator of a wide area network.
Collaborati ve Indoor Localization of Mobile Nodes (2012)

In this paper, we firstly survey start-of-the-art indoor localization methods which have been extensively studied in recent years. Most of the existing localization methods for indoor people have mainly focused on localization supported by infrastructure. However, considering new applications such as in-room navigation with a people crowd (like in exhibition halls and shopping malls) or social and business activity support that often needs interaction among people, we may reach a different solution that leverages mobile devices of surroundings for more cost-efficient, accurate positioning. Then we seek such a possibility, collaborative indoor localization of mobile nodes, and discuss technical challenges that have not been unsolved so far. Finally, we introduce our two indoor localization approaches that are based on mobile node collaboration. We address their benefit and discuss future research directions.
Les moins de cent ans (1929)

Plant genome size has many applications in different biological fields including ecology and plant breeding. The 2C value for <i>Vitis vinifera</i> L. has not been widely studied; furthermore, to date, no data from local landraces in the Pityusic Islands (the two smaller inhabited Balearic Islands, Ibiza, and Formentera) have been reported. This research aims to contribute to this knowledge and investigate whether there are variations between different grape landraces cultivated in Ibiza and Formentera and also among the same landraces on each island. To this end, 36 accessions of 15 cultivars and 6 landraces, identified with SSR markers, were assessed using flow cytometry. The results revealed that 2C values ranged from 1.09 pg to 1.28 pg. There were statistically significant differences in 'AG1' and 'AG2' landraces and 'Santa Magdalena', 'Garnatxa', 'Danugue', and 'Valencí tinto/Grumier' cultivars. No statistically significant differences were found in terms of the genome size content between islands. Statistically significant differences were found in accessions within 'AG2' landrace group and 'Beba' cultivar. The results presented here constitute the first-ever reported information on genome size in the genus <i>Vitis vinifera</i> in Pityusic, Balearic, and, in general, Spanish accessions, and they are one of the largest prospections in this field for this species anywhere. Further research should be conducted to explain the differences in nuclear DNA content found between landraces and cultivars studied here with others cultivated in different islands or countries to understand whether genome size varies in modern cultivars compared with local landraces. Additionally, it would be interesting to investigate whether there is a relationship between genome size and adaptations to diverse climatology conditions, crop management, and ripening characteristics.
Functional upregulation of granulocytes labeled with technetium-99m-HMPAO and indium-111-oxinate. (1996)

These data were obtained in normal volunteers. In patients, alterations due to the in vitro labeling procedure, in addition to potential functional alterations caused by the underlying pathology, should be taken into account during image interpretation.
Elimination of Circulating Serum Protein Antigens as a Sensitive Measure of Antibody. (1960)

Immune elimination of antigen using very small amounts of antigen and antibody occurs in characteristic fashion in rabbits, guinea pigs and mice and may be used as an additional sensitive method for demonstration of small amounts of antibody against serum protein antigens. Consideration of these findings in regard to the hypothesis of natural antibodies is discussed.
On modeling hard combinatorial optimization problems as linear programs: Refutations of the "unconditional impossibility" claims (2019)

There has been a series of developments in the recent literature (by essentially a same "circle" of authors) with the absolute/unconditioned (implicit or explicit) claim that there exists no abstraction of an NP-Complete combinatorial optimization problem in which the defining combinatorial configurations (such as "tours" in the case of the traveling salesman problem (TSP) for example) can be modeled by a polynomial-sized system of linear constraints. The purpose of this paper is to provide general as well as specific refutations for these recent claims.
Extending the scope of enantiomer resolution by complexation gas chromatography (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtending the scope of enantiomer resolution by complexation gas chromatographyVolker Schurig and Waldemar BuerkleCite this: J. Am. Chem. Soc. 1982, 104, 26, 7573–7580Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/ja00390a031https://doi.org/10.1021/ja00390a031research-articleACS PublicationsRequest reuse permissionsArticle Views464Altmetric-Citations212LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Initiation of biofilm formation in <i>Pseudomonas fluorescens</i> WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis (1998)

Populations of surface-attached microorganisms comprising either single or multiple species are commonly referred to as biofilms. Using a simple assay for the initiation of biofilm formation (e.g. attachment to an abiotic surface) by Pseudomonas fluorescens strain WCS365, we have shown that: (i) P. fluorescens can form biofilms on an abiotic surface when grown on a range of nutrients; (ii) protein synthesis is required for the early events of biofilm formation; (iii) one (or more) extracytoplasmic protein plays a role in interactions with an abiotic surface; (iv) the osmolarity of the medium affects the ability of the cell to form biofilms. We have isolated transposon mutants defective for the initiation of biofilm formation, which we term surface attachment defective (sad). Molecular analysis of the sad mutants revealed that the ClpP protein (a component of the cytoplasmic Clp protease) participates in biofilm formation in this organism. Our genetic analyses suggest that biofilm formation can proceed via multiple, convergent signalling pathways, which are regulated by various environmental signals. Finally, of the 24 sad mutants analysed in this study, only three had defects in genes of known function. This result suggests that our screen is uncovering novel aspects of bacterial physiology.
Advanced Capillary Soft Valves for Flow Control in Self-Driven Microfluidics (2013)

Self-driven microfluidic devices enable fully autonomous handling of very small volumes of liquid samples and reagents. However, many applications require an active control mechanism to trigger self-driven flow in microchannels. Here, we report on capillary soft valves (CSVs), which enable stopping a liquid filling front at a precise location inside a microchannel and can resume flow of liquid upon simple actuation. The working mechanism of a CSV is based on a barrier of capillary pressure induced by an abruptly expanding microchannel. We discuss the influence of wetting conditions on the performance of a CSV and the effect of elevated temperatures on a CSV in its closed state. We introduce design features such as pillars and cavities, as well as fabrication techniques for rounded microchannels, which all may broaden the applicability and robustness of CSVs in microfluidic devices. Finally, we present CSV having multiple inlet channels. CSVs further diversify the toolbox of microfluidic functionalities and yet are simple to implement, fabricate and actuate.
Dynamic RNA-RNA Interactions in the Spliceosome (1994)

We have made rapid progress in recent years in identifying the genetic causes of many human diseases. However, despite this recent progress, our mechanistic understanding of these diseases is often incomplete. This is a problem because it limits our ...Read More
Effect of cytokines on specific in vitro immunization of human peripheral B lymphocytes against T-cell dependent antigens. (1987)

The requirements for a primary, antigen-specific in vitro immunization of human peripheral lymphocytes using haemocyanin, a T-cell dependent antigen, have been studied. In order to obtain a specific response in vitro the peripheral lymphocytes had to be separated into B, T, accessory (A) and dendritic (D) cells. These cells were activated and reconstituted to give a population with a B:T ratio of 1:2. If the induction was supported by MHC-restricted, radioresistant T cells, this cell population could then be antigen-specifically activated using haemocyanin. The immunization had also to be supported by cytokines, such as B-cell growth and differentiation factors, interleukin-2 and gamma-interferon. A 5-day in vitro immunization using 2 micrograms haemocyanin/ml resulted in 200-300 cells secreting anti-haemocyanin-specific antibodies per 10(6) B cells.
Arquitectura de Control de una Plataforma Robótica sin Realimentación de Posición Articular para Cirugía Minimamente Invasiva (2015)

Rivas-Blanco, I.; Muñoz, V.F.; García-Morales, I.; Tortora, G.; Menciassi, A., "Arquitectura de Control de una Plataforma Robótica sin Realimentación de Posición Articular para Cirugía Minimamente Invasiva," Actas de las XXXVI Jornadas de Automática, Bilbao, Spain, pp.793-800, Sep. 2015
Mouse β1C-Globulin: Production of Antiserum and Characterization in the Complement Reaction (1965)

Summary Highly specific antibody to mouse β1C-globulin has been produced in rabbits by injecting incomplete Freund's adjuvant containing mouse complement adsorbed onto zymosan. The production of this antisera enabled analysis of the interaction of mouse β1C-globulin with EAC′1,4,2a cells, antigen-antibody precipitates and zymosan. The data revealed that the immediate reaction product upon interaction of β1C-globulin in these in vitro immune systems was a rapidly migrating β-α2-globulin, called β1C-globulin, and that this product was then transferred into an inactive, more slowly migrating component, β1D-globulin. Ultracentrifugal analysis showed β1C-globulin to have an s-rate of 9.5 S, β1D-globulin to have an s-rate of 6.5 S and β1G-globulin to have an intermediate s-rate. A close similarity is shown to exist between human β1C-, β1G- and β1A-globulin and their mouse homologues.