gebhart/patrepeval huggingface dataset:
Five Possible Isocyanoazulenes and Electron-Rich Complexes Thereof:  A Quantitative Organometallic Approach for Probing Electronic Inhomogeneity of the Azulenic Framework (2005)

Efficient syntheses of all five possible isocyanoazulenes, the four isomeric archetypal compounds CN1Az, CN2Az, CN4Az, and CN6Az, as well as the 1,3-di-tert-butyl derivative of CN5Az (Az = azulenyl), are described. Compounds CN1Az and CN2Az show unexpected shifts of the S0 → S1 transition in their electronic spectra relative to azulene. The origins of these “anomalous” shifts have been addressed by DFT calculations, cyclic voltammetry, and comparison of the electronic spectra of isocyanoazulenes with those of the corresponding isomeric cyanoazulenes. Despite the high propensity of the azulenic nucleus to undergo multihapto coordination and C−C coupling in the presence of low-valent metals, the isocyanoazulenes react with 1/6 equiv of Cr(η6-naphthalene)2 to afford thermally stable Cr(CNxAz)6 (x = 1, 2, 4, 6), which contain six discrete azulenyl groups separated from the Cr center by isocyanide linkers. All Cr(CNxAz)6 species undergo oxidation to form the corresponding paramagnetic cations [Cr(CNxAz)6]+, which have been crystallographically characterized. Changing the atom of attachment of the azulenyl groups to the “Cr(CN)6” core substantially alters the donor/acceptor properties of the isocyanoazulene ligands. The half-wave Cr0/+ and Cr+/2+ redox potentials for [Cr(CNxAz)6]z form the “electrochemical series” that constitutes a quantitative measure of electronic inhomogeneity of the azulenic framework. Unpaired spin delocalization within the azulenic moieties of [Cr(CNxAz)6]+ has been observed by multinuclear NMR. The CrI(dπ)→CNxAz(pπ*) interaction has been shown to be an important contributor to the mechanism of unpaired electron delocalization in [Cr(CNxAz)6]+.
Energy of internal modes and universality of complex frequencies in systems with broken symmetries: Examples from intracavity optics and BE (2001)

Unifying explanation to the ubiquity of instabilities with complex frequencies of localised structures in coherently pumped nonlinear optical cavities and vortices in trapped Bose-Einstein condensates is suggested. It is based on notion of the energy sign of the internal modes of nonlinear waves and symmetry breaking ideas.
Sea Urchin Population Explosion in Southern California Coastal Waters (1970)

The alleged population "explosion" of coral-eating sea stars (Acanthaster planci) in the west tropical Pacific (1)\nmay be comparable to the apparent population "explosion" of herbivorous sea urchins (Strongylocentrotus franciscanus\nand S. purpuratus) along the coast of southern California. Many luxuriant kelp beds, supporting a rich association of other organisms, have all but disappeared during the past few decades, and in the place of the holdluxuriant holdfasts\nare barren areas supporting extremely dense populations of the urchins (2).
Multiuser detection in multipath environments for variable spreading-factor CDMA systems (2001)

A way to allow variable data rates in CDMA is by varying the spreading factor in accordance with the data rate requested by the user. A detection scheme suitable for multirate transmission is required in addition to one that combats multiple access interference of other users and intersymbol interference from multipath. In this letter, an energy-add multiuser detection method is combined with a scheme called Cholesky-iterative detection to cope with these challenges. It allows the users to be estimated on a symbol-by-symbol basis, making receiver complexity independent of data package length. Simulation results correspond closely to a single-user lower bound. The results also show that the bit-error probability performances of the various users for the Cholesky-iterative detector are closely clustered, while those of a previously published scheme, decorrelation feedback detection, are more widely spread.
A possible role for maternal HLA antibodyin a case of alloimmune neonatal neutropenia (2001)

These results suggest that the transplacental passage of the maternal HLA antibody caused neutropenia in this patient.
Amniotic membrane transplantation (2011)

Abstract Purpose Aim of this presentation is to indicate current applications of amniotic membrane transplantation in corneal diseases and to describe, by means of in vivo imaging techniques, postoperative modifications of corneal tissue. Methods Different indications for Amniotic Membrane Transplantation will be presented as clinical cases and literature review including corneal ulcers and perforations, persistent epithelial defect, bullous keratopathy. Surgical techniques and adverse events will be described and morphological changes of transplanted tissue and corneal profile will be analyzes by means of anterior segment OCT and in vivo confocal microscopy. Results Amniotic membrane transplantation allows to obtain epithelial restoring, corneal sealing and stromal thickness recovery together with an antinflammatory effect on corneal tissue and reduction of pain. Transplanted tissue may be differently oriented and composed to obtain different effects on recipient cornea. Conclusion Amniotic membrane transplantation is an useful surgical technique for managing of ulcerative corneal pathologies with or without perforation and epithelial defects. In vivo imaging diagnostic devices enable to visualize postoperative effects of transplanted tissue on recipient cornea in terms of morphology and tissutal modifications.
Survival of quantum effects for observables after decoherence (6 pages) (2004)

Anesthetic hepatotoxicity was tested under various conditions of hypoxia in rats pretreated with phenobarbital. Administration of 0.3 MAC halothane or fentanyl in 9% oxygen (fractional concentration of inspired oxygen = 0.09) for 46 min produced centrilobular hepatic injury in all rats (P less than 0.001 vs all other groups). Isoflurane, nitrous oxide, and thiopental at 0.3 MAC did not produce hepatic injury greater than that produced in control rats given 9% oxygen, nor was significant injury produced in control phenobarbital-pretreated rats who breathed 6 or 7.5% oxygen for 46 min. With an inspired oxygen concentration of 7.5%, hepatic injury occurred after exposure to 92.5% nitrous oxide (P less than 0.05), but not after enflurane, isoflurane, or thiopental. When hypoxia associated with 9% oxygen was extended to 2 hr, 91% nitrous oxide produced significant injury (P less than 0.001 compared with the controls), while enflurane, isoflurane, and thiopental did not. These and previous results suggest that all anesthetics can produce liver injury in the hypoxic rat model and that the ranking of hepatotoxicity (most to least) may be halothane, fentanyl, nitrous oxide, enflurane = isoflurane = thiopental.
Effect of adenosine triphosphate on beef cardiac actomyosin (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of adenosine triphosphate on beef cardiac actomyosinAda L. Jacobson, W. G. Cambell, and Jerry M. AdamsCite this: Biochemistry 1971, 10, 6, 1063–1067Publication Date (Print):March 16, 1971Publication History Published online1 May 2002Published inissue 16 March 1971https://pubs.acs.org/doi/10.1021/bi00782a020https://doi.org/10.1021/bi00782a020research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A PHASE I STUDY: THE SIDE-EFFECT PROFILE OF AN INTERCELLULAR ADHESION MOLECULE-1 ANTISENSE PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE, ISIS 2302. (1998)

244 Purpose: A phase I study in quiescent cyclosporine-prednisone(CsA-Pred) -treated renal transplant patients was performed to assess the safety and efficacy of ISIS 2302. Method: 16 stable cadaveric renal transplant patients (mean 3.2 years post-transplant) on a CsA-Pred dual-drug regimen received eight i.v. infusions of the intercellular adhesion molecule-1 antisense phosphorothioate oligodeoxynucleotide, ISIS 2302, in an ascending dose (0.05, 0.5, 1, or 2 mg/kg), double-blinded, placebo-controlled trial, with drug infusions over 6, 4, and 2 hours. Patients were randomized to active drug: placebo 3:1 ratio. Results: The outcomes were compared with a phase I trial in 44 normal volunteers. The primary side effects of ISIS 2302 were a significant and dose-related increase in PTT and a trend toward a decrease in platelet count. The effect was less pronounced with the slower infusion rate (6 hours vs. 2 hours) and did not increase with multiple dosing. In contrast to experience in normal volunteers, there were no significant changes in C3a, or indeed in C4a and C5a. No consistent changes from baseline or alteration in mean values were observed for serum creatinine, serum transaminases, bilirubin, hematocrit, or white blood cell count. Two profiles of CsA pharmacokinetics were unchanged from pretransplant profiles. There were no adverse clinical events associated with drug administration; specifically, there was no tendency toward a bleeding diathesis. However, one treated patient reported epistaxis, and one control patient experienced menorrhagia at a time remote from the infusion. Thereafter, we initiated a phase I/II trial(currently underway and still blinded). Using similar ascending doses, ISIS 2302 was administered for seven doses on a q.o.d. schedule to de novo renal transplant recipients. We have completed the first two dose levels randomized in a 3:1 active drug: placebo ratio and are almost finished with the last dose level (6:2 active drug: placebo). The safety is apparent; the efficacy will be reported following unblinding. Conclusions: The phase I trial showed that ISIS 2302 is a safe and efficacious drug in stable renal transplant patients, with fewer side effects than in normal volunteers. The dose-related increase in PTT was not clinically significant and can be abrogated by slower infusion rates. These data provide a foundation for wider clinical trials.TableMean Post-Pre PTT Difference
Effects of Inlet Flow Boundary Conditions on the Thermal Performance of a Plate-Fin Heat Sink With an Impinging Flow (2011)

This paper discusses the effect of inlet flow boundary conditions on the performance of a plate-fin heat sink with an impinging flow. The inlet flow boundary conditions of the plate-fin heat sink are decided by duct configurations and heat sink geometries. First, velocity distributions according to the inlet flow boundary conditions of the plate-fin heat sink are obtained using numerical simulations. These results clearly show that the inlet flow boundary condition is divided into two branches: one is uniformly impinging flow and the other is non-uniformly impinging flow. Also, the fluid characteristics of the plate-fin heat sink with an impinging flow according to the inlet flow boundary conditions are experimentally examined by measuring the stagnation pressure distributions on the bottom of the plate-fin heat sink. Based on Do et al., correlations for pressure drop and thermal resistance of the plate-fin heat sink with uniformly impinging flow are proposed. Also, pressure drop and thermal resistance correlations of the plate-fin heat sink with uniformly impinging flow are compared with those of the plate-fin heat sink with non-uniformly impinging flow using correlations suggested by Kim et al. Finally, it is shown that the plate-fin heat sink with uniformly impinging flow has a lower thermal resistance than the plate-fin heat sink the non-uniformly impinging flow when the dimensionless length of the plate-fin heat sink is small and the dimensionless pumping power is large.
Effects of Some Plant Growth Promoting Rhizobacteria (PGPR) on Graft Union of Grapevine (2005)

ABSTRACT In this study, effects of topical applications of three plant growth promoting rhizobacteria (PGPR) strains (Pseudomonas BA8, Bacillus BA16 and Bacillus OSU142) on graft union were evaluated in terms of success rate, callusing rate, callusing degree and full callusing rate on four different rootstock-scion combinations including 41B-Beyaz Çavuş, 41B-Italia, 5BB-Beyaz Çavuş and 5BB-Italia. The results showed that in general all of the bacterial strains had significant effects on all parameters tested in all rootstock-scion combinations compared with the control. Application of Pseudomonas BA8 in 41B-Beyaz Çavuş, Bacillus OSU142 in 41B-Italia, Pseudomonas BA8 in 5BB-Beyaz Çavuş, and Bacillus BA16 and Bacillus OSU142 in 5BB-Italia combination increased the success rate (83.3%, 93.3%, 80.0% and 86.7%, respectively) compared with the control (23.3%, 80.0%, 60.0% and 70.0%, respectively). Application of PGPR also increased the callusing rate, callusing degree and full callusing rate in all rootstock-scion combinations compared with control. Among the bacteria strains tested, Pseudomonas BA8 was the most effective PGPR strain which can be used for graft union of grapevine grown in commercial, sustainable or organic agriculture.
<i>Verticillium longisporum</i> , the invisible threat to oilseed rape and other brassicaceous plant hosts (2015)

Summary Introduction The causal agents of Verticillium wilts are globally distributed pathogens that cause significant crop losses every year. Most Verticillium wilts are caused by V. dahliae , which is pathogenic on a broad range of plant hosts, whereas other pathogenic Verticillium species have more restricted host ranges. In contrast, V. longisporum appears to prefer brassicaceous plants and poses an increasing problem to oilseed rape production. Taxonomy Kingdom Fungi; Phylum Ascomycota; Class Sordariomycetes; Subclass Hypocreomycetida; Family Plectosphaerellaceae; genus Verticillium . Disease symptoms Dark unilateral stripes appear on the stems of apparently healthy looking oilseed rape plants at the end of the growing season. Microsclerotia are subsequently formed in the stem cortex beneath the epidermis. Genome Verticillium longisporum is the only non‐haploid species in the Verticillium genus, as it is an amphidiploid hybrid that carries almost twice as much genetic material as the other Verticillium species as a result of interspecific hybridization. Disease management There is no effective fungicide treatment to control Verticillium diseases, and resistance breeding is the preferred strategy for disease management. However, only a few Verticillium wilt resistance genes have been identified, and monogenic resistance against V. longisporum has not yet been found. Quantitative resistance exists mainly in the Brassica C‐genome of parental cabbage lines and may be introgressed in oilseed rape breeding lines. Common name Oilseed rape colonized by V. longisporum does not develop wilting symptoms, and therefore the common name of Verticillium wilt is unsuitable for this crop. Therefore, we propose ‘Verticillium stem striping’ as the common name for Verticillium infections of oilseed rape.
Endoscopic robotically-assisted mitral valve repair (2009)

Robotic surgical instrumentation allows minimally invasive mitral valve repair through an endoscopic approach, eliminating the need for a thoracotomy. Robotic instruments are inserted through port-like incisions in the right hemithorax, while cardiopulmonary bypass is established via cannulation of the femoral vessels. We describe triangular resection, a simple and reproducible robotically-assisted technique for repair of posterior leaflet prolapse. The repair is completed with insertion of an annuloplasty ring.
Congo red binding and salt aggregation as indicators of virulence in Shigella species (1988)

Smooth strains of Shigella dysenteriae type 1, Shigella flexneri, Shigella boydii, and Shigella sonnei which form pigmented colonies (Pcr+) on Congo red agar were virulent in the Sereny test. Smooth variants unable to bind Congo red (Pcr-) were avirulent. Measurements of dye uptake from solution showed that S. dysenteriae type 1 bound the most dye, followed in order of uptake by S. flexneri, S. boydii, and S. sonnei. Using the salt aggregation test (SAT) to determine cell surface hydrophobicity, we found the same order of species. The SAT could not, however, detect differences in surface properties between Pcr+ and Pcr- pairs of isogenic smooth strains. Enteroinvasive Escherichia coli strains used in the study showed SAT and Congo red-binding properties which were similar to those of the S. flexneri strains. A direct correlation was found between pigment-binding ability and the presence of the large 140-megadalton plasmid in S. flexneri, enteroinvasive E. coli, and S. boydii but not in S. dysenteriae type 1 or S. sonnei strains. Congo red interacted with outer membranes and outer membrane proteins of S. dysenteriae type 1 but not with lipopolysaccharides. However, rough mutants of Shigella species deficient in lipopolysaccharides bound Congo red and formed pigmented colonies, showing that dye binding as a virulence assay may be misinterpreted in such cases. There was complete correlation of the Pcr+ phenotype with virulence in the smooth strains in this study, suggesting that Congo red binding can be utilized as a quick and reliable alternative to the Sereny test.
Production of conidia by <i>Phomopsis convolvulus</i> (1990)

Various solid-substrate fermentation and shake-flask liquid fermentation systems were investigated as spore production methods for Phomopsis convolvulus, a potential bioherbicide. Among them, "pot" barley grains and modified Richard's (V-8) liquid medium produced 5 × 10 8 conidia/g and 5 × 10 6 conidia/mL, respectively. Distinct pycnidia, covering the surface of pot barley grains, produced virulent conidia in a water-soluble mucilage approximately 10 days after seeding the substrate with conidia. In complex liquid media, conidia were produced in pycnidia 3 to 4 days after seeding the media with mature pycnidia or conidia. A negative relationship was demonstrated between inoculum density and yield of conidia in modified Richard's (V-8) liquid culture. Omission of V-8 juice or decrease of the carbon to nitrogen ratio in modified Richard's (V-8) medium inhibited sporulation. Conidia lost viability after 30 days when held at −10 °C in a sucrose solution, but conidia stored at −70 °C remained viable and pathogenic for at least 6 months. Key words: Phomopsis convolvulus, bioherbicide, sporulation.
Short Span Segmental Bridges in Czechoslovakia (1986)

R ecently, two distinct types of precast prestressed segmental bridge design have been developed in Czechoslovakia. These designs are suitable for both urban and highway bridges with spans 'ranging up to 150 ft (45 m). The first design (Fig. 1) consists of box segments transversely connected by the top flange while the second alternative (Fig. 2) utilizes segments of open, double-tee cross sections. The development of these bridges was preceded by the successful construction of several segmental overpasses (Fig. 3). Although these bridges were built under different social and economic conditions, some of their structural features and construction methods have interest and applicability to projects in other parts of the world. The following features are common to all the bridge structures described herein: 1. The superstructure consists of precast match-cast segments with a specified cube strength of about 7000 psi (50 MPa). Shortline horizontal casting was used to produce all constant-depth segments while adjustable forms allowed for both horizontal and vertical curves and variations in superelevation. The segments of the box cross si tions were cast in forms similar to the developed by Campenon and Bernard. 2 T double-tee members were cast in forms i ing a new concept. The segments are c. in one-day production cycles and the curi of the concrete was accelerated by steami the freshly cast components. 2. To control temperature and humid variations, deicing salts, and different ere and shrinkage ratios of the segment sly and webs, the joints between segments we covered with epoxy resin during assemb Also, the faces of the segments were pi vided with multiple keys and erected cantilever. This made it easier for the pi cast segments to adjust to their proper 1 sition after temporary post-tensioning. 3. The erection process was designed such a way that the structural configurati of the bridge would not be affected by t redistribution of creep caused by volume stress changes. 4. During the course of erection, the perstructure was gradually post-tension by two systems of tendons: straight tend( placed in the deck and draped tendons plac
Identification of biotinylated proteins in soybean [<i>Glycine max</i> (L.) Merrill] seeds and their characterization during germination and seedling growth (1997)

Abstract Biotin is an important vitamin. It is biologically active as a protein prosthetic group, where it functions in enzymatically catalysed carboxylation reactions. It has previously been shown that the ability to synthesize biotin is not necessary for germination of Arabidopsis thaliana seeds, but that this process is required for early seedling growth. This research was conducted to determine if changes in the detection of biotinylated proteins could be observed that reflect changes in the need for biotin-mediated enzyme reactions observed during early soybean seedling growth. A seed specific 75-kDa biotinylated protein present in the embryonic axes and the cotyledons was lost during the first 3 d of germination. Seed specificity, and pattern of expression during germination suggest that this protein is a homologue of the seed specific 65-kDa biotinylated protein previously identified in pea ( Pisum sativum ). If samples were not treated with 2-mercaptoethanol, three equally spaced proteins at approx. 85 kDa were visible. In the presence of 2-ME these proteins appeared as a single 85-kDa band. This triplet was distinct only in the embryonic axes of dry seeds and not in imbibed seeds or in other plant parts. This demonstrates that imbibitional changes do occur in the pool of biotinylated proteins present in dry soybean seeds, and that 2-ME treatment can inhibit complete identification of the biotinylated proteins present in seed tissues.
Mammalian Homolog of<i>Drosophila retinal degeneration B</i>Rescues the Mutant Fly Phenotype (1997)

Mutations in the Drosophila rdgB gene, which encodes a transmembrane phosphatidylinositol transfer protein (PITP), cause a light-enhanced retinal degeneration. Cloning of mammalian rdgB orthologs ( mrdgB ) reveal predicted proteins that are 39% identical to rdgB , with highest homology in the N-terminal PITP domain (62%) and in a region near the C terminus (65%). The human mrdgB gene spans ∼12 kb and maps to 11q13.1, a locus where several retinal diseases have also been mapped. Murine mrdgB maps to a syntenic region on the proximal region of chromosome 19. MrdgB is specifically expressed in the retina and brain. In the retina, MrdgB protein is localized to photoreceptor inner segments and the outer and inner plexiform layers. Expression of murine mrdgB in mutant flies fully rescues both the rdgB -dependent retinal degeneration and abnormal electroretinogram. These results suggest the existence of similarities between the invertebrate and mammalian retina that were not previously appreciated and also identify mrdgB as a candidate gene for retinal diseases that map to 11q13.1.