gebhart/patrepeval huggingface dataset:
The Golden ratio, ionic and atomic radii and bond lengths (2005)

Abstract This work arose from the author's finding that the ratio of the radius of hydrogen, estimated recently (C.H. Suresh, N. Koga, J. Phys. Chem. A, 105, 5940 (2001)) by density functional methods, to the ground state Bohr radius is the Golden ratio, which operates in a variety of natural phenomena. It is found that the Golden ratio indeed plays a quantitative role in atomic physics. The interesting results are (1) that it arises in atomic dimensions due to the electrostatic forces between negative and positive charges; (2) that the energy of atomic hydrogen is actually equivalent to the energy of the simplest atomic condenser with the Golden mean capacity; (3) that the origin of two terms in the Rydberg equation for absorption and emission is in fact in the ground state term; (4) that all atoms can be assigned definite values of cationic and anionic radii based on the Golden ratio and covalent radii; (5) that these radii are additive and explain quantitatively bond lengths like those of alkali halides, of hydrides of many elements and of many other bonds, whether covalent or ionic or both; and (6) that the work functions of alkali metals can be evaluated using the bond lengths. Acknowledgement The author is grateful for the grant from Project of the Ministry of Industry and Trade of the Czech Republic, Nr. 1H-PK/42.
Logic-structure tables (1961)

Logic tables are an excellent way of developing and expressing the logic required in procedures, operations, systems and circuits. A set of rules for writing and using logic tables is explained by means of some simple examples. Then the logic structure of a vending machine is given in which two logic tables are used. Logic tables are two-dimensional in nature, enabling us to fully express and consider both the sequential and parallel aspects of logic. They can be compiled directly into a computer program and so eliminate the need for flow charting and hand coding.
Microfluidic tools for developmental studies of small model organisms –nematodes, fruit flies, and zebrafish (2012)

Studying the genetics of development with small model organisms such as the zebrafish (Danio Rerio), the fruit fly (Drosophila melanogaster), and the soil-dwelling nematode (Caenorhabditis elegans), provide unique opportunities for understanding related processes and diseases in humans. These model organisms also have potential for use in drug discovery and toxicity-screening applications. There have been sweeping developments in microfabrication and microfluidic technologies for manipulating and imaging small objects, including small model organisms, which allow high-throughput quantitative biological studies. Here, we review recent progress in microfluidic tools able to manipulate small organisms and project future directions and applications of these techniques and technologies.
Glycopyrrolate and Atropine Inhalation: Comparative Effects on Normal Airway Function <sup>1,</sup> <sup>2</sup> (1984)

Bronchodilation was produced in normal subjects by inhalation of high doses of a quaternary parasympatholytic agent (glycopyrrolate), and responses were compared with those of atropine and a placebo. Both drugs induced significant increases in specific airway conductance (SGaw) and forced expiratory flows, but the effects of glycopyrrolate were sustained significantly longer (greater than 6 h). Whereas atropine produced an increased heart rate (26%) and severe dry mouth in all subjects, these symptoms were absent with glycopyrrolate and placebo. Therefore, glycopyrrolate produces significant bronchodilation of long duration but free of the side effects of muscarinic blockade that characterize atropine inhalation.
Angiomyolipoma of the lung. (1998)

Extrarenal angiomyolipomas are rare tumors that have been reported in several organs, including the liver, reproductive organs, skin, and retroperitoneum. In this report, we present the clinicopathologic findings of an angiomyolipoma of the lung in a 67-year-old man with no history of tuberous sclerosis or lymphangioleiomyomatosis. To our knowledge, this is the second reported case of pulmonary angiomyolipoma. The tumor was coincidentally found in the left lower lung in association with a hemothorax. Our case was histologically identical to angiomyolipoma occurring in the kidney, but immunohistologic staining for HMB-45 was negative, similar to the first reported case.
Gamma‐, photo‐, and thermally‐initiated oxidation of linear low density polyethylene: A quantitative comparison of oxidation products (1992)

Abstract The detailed oxidation products from the initiated oxidation of linear low density polyethylene have been compared by the use of infrared spectroscopy combined with chemical derivatization. Oxidized films were treated with NO or SF 4 to allow the resolution of the various alcohol and hydroperoxides and of the carbonyl species, respectively. All types of initiation gave very similar products but in varying quantities. In photooxidation, hydroperoxide was clearly shown to approach a photostationary concentration either from below for fresh film or from above for samples that had been pre‐oxidized by γ‐irradiation, prior to UV exposure. Carboxylic acid groups, the main backbone scission product, dominated in photooxidations, possibly as the result of the further oxidation of sec ‐hydroperoxide sites.
A statistical theory of target detection by pulsed radar (1960)

This report presents data from which one may obtain the probability that a pulsed-type radar system will detect a given target at any range. This is in contrast to the usual method of obtaining radar range as a single number, which can be taken mathematically to imply that the probability of detection is zero at any range greater than this number, and certainty at any range less than this number. Three variables, which have so far received little quantitative attention in the subject of radar range, are introduced in the theory: l.The time taken to detect the target. 2.The average time interval between false alarms (false indications of targets). 3.The number of pulses integrated. It is shown briefly how the results for pulsed-type systems may be applied in the case of continuous-wave systems. Those concerned with systems analysis problems including radar performance may profitably use this work as one link in a chain involving several probabilities. For instance, the probability that a given aircraft will be detected at least once while flying any given path through a specified model radar network may be calculated using the data presented here as a basis, provided that additional probability data on such things as outage time etc., are available. The theory developed here does not take account of interference such as clutter or man-made static, but assumes only random noise at the receiver input. Also, an ideal type of electronic integrator and detector are assumed. Thus the results are the best that can be obtained under ideal conditions. It is not too difficult, however, to make reasonable assumptions which will permit application of the results to the currently available types of radar. The first part of this report is a restatement of known radar fundamentals and supplies continuity and background for what follows. The mathematical part of the theory is not contained herein, but will be issued subsequently as a Separate report(2a)
Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann–Pick type C disease fibroblasts (2012)

Niemann-Pick type C disease is a lysosomal storage disorder most often caused by loss-of-function mutations in the NPC1 gene. The encoded multipass transmembrane protein is required for cholesterol efflux from late endosomes and lysosomes. Numerous missense mutations in the NPC1 gene cause disease, including the prevalent I1061T mutation that leads to protein misfolding and degradation. Here, we sought to modulate the cellular proteostasis machinery to achieve functional recovery in primary patient fibroblasts. We demonstrate that targeting endoplasmic reticulum (ER) calcium levels using ryanodine receptor (RyR) antagonists increased steady-state levels of the NPC1 I1061T protein. These compounds also promoted trafficking of mutant NPC1 to late endosomes and lysosomes and rescued the aberrant storage of cholesterol and sphingolipids that is characteristic of disease. Similar rescue was obtained using three distinct RyR antagonists in cells with missense alleles, but not with null alleles, or by over-expressing calnexin, a calcium-dependent ER chaperone. Our work highlights the utility of proteostasis regulators to remodel the protein-folding environment in the ER to recover function in the setting of disease-causing missense alleles.
Mudra: A Study of Symbolic Gestures in Japanese Buddhist Sculpture (1961)

Appearing for the first time in paperback and illustrated with line drawings, diagrams, and 26 half-tone plates, this study of the iconographic aspect of Japanese Buddhist sculpture surveys the significance of eight principal and six secondary hand gestures (mudra), in addition to the postures (asana), such as the lotus, and the symbolic attributes. A pictorial index helps the reader in identifying the gestures.
Analysis of GMSK with differential detection in land mobile radio channels (1986)

The effect of intersymbol interference (ISI) of Gaussian Filtered Minimum Shift Keying (GMSK) on the probability of error of one bit differential detection is analyzed theoretically in fast Rayleigh fading characterizing land mobile radio channels. A closed form expression is derived for the probability of error as a function of the fading rate, IF Filter Bandwidth, signal-to-noise ratio and ISI. Numerical results are presented for cases of practical interest to researchers and designers of cellular land mobile radio systems.
A DTI-Derived Measure of Cortico-Cortical Connectivity (2009)

We arm researchers with a simple method to chart a macroscopic cortico-cortical connectivity network in living human subjects. The researcher provides a diffusion-magnetic resonance imaging (MRI) data set and N cortical regions of interest. In return, we provide an N xN structural adjacency matrix (SAM) quantifying the relative connectivity between all cortical region pairs. We also return a connectivity map for each pair to enable visualization of interconnecting fiber bundles. The measure of connectivity we devise is: 1) free of length bias, 2) proportional to fiber bundle cross-sectional area, and 3) invariant to an exchange of seed and target. We construct a 3-D lattice scaffolding (graph) for white-matter by drawing a link between each pair of voxels in a 26-voxel neighborhood for which their two respective principal eigenvectors form a sufficiently small angle. The connectivity between a cortical region pair is then measured as the maximum number of link-disjoint paths that can be established between them in the white-matter graph. We devise an efficient Edmonds-Karp-like algorithm to compute a conservative bound on the maximum number of link-disjoint paths. Using both simulated and authentic diffusion-tensor imaging data, we demonstrate that the number of link-disjoint paths as a measure of connectivity satisfies properties 1)-3), unlike the fraction of intersecting streamlines-the measure intrinsic to most existing probabilistic tracking algorithms. Finally, we present connectivity maps of some notoriously difficult to track longitudinal and contralateral fasciculi.
Wearable and Mobile System to Manage Remotely Heart Failure (2009)

Cardiovascular diseases (CVDs) account for 45% of all deaths in the western world according to the 2004 World Health Organization statistics report. Heart failure (HF), CVD's primary paradigm, mainly affects people older than 65. The European MyHeart Project's mission is to empower citizens to fight CVD by leading a preventative lifestyle and allowing early diagnosis. This paper presents the iterative design and development of the HF management system, part of MyHeart Project. The system daily measures vital body signals to assess HF. The methodology applied herein has involved stakeholders in an iterative process: concept validation, feasibility, efficiency, patients' experience, and patients' acceptance. The final solution allows patient self-management of their chronic condition.
Cardiovascular effects of lansoprazole and nizatidine. (1996)

Clinical Pharmacology & Therapeutics (1996) 59, 193–193; doi: 10.1038/sj.clpt.1996.273
The Novel Selected-ion Flow Tube Approach to Trace Gas Analysis of Air and Breath (1996)

We present an overview of the development and use of our selected-ion flow tube (SIFT) technique as a sensitive, quantitative method for the rapid, real-time analysis of the trace gas content of atmospheric air and human breath, presenting some pilot data from various research areas in which this method will find valuable application. We show that it is capable of detecting and quantifying trace gases, in complex mixtures such as breath, which are present at partial pressures down to about 10 parts per billion. Following discussions of the principles involved in this SIFT method of analysis, of the experiments which we have carried out to establish its quantitative validity, and of the air and breath sampling techniques involved, we present sample data on the detection and quantification of trace gases on the breath of healthy people and of patients suffering from renal failure and diabetes. We also show how breath ammonia can be accurately quantified from a single breath exhalation and used as an indicator of the presence in the stomach of the bacterium Helicobacter pylori. Health and safety applications are exemplified by analyses of the gases of the gases of cigarette smoke and on the breath of smokers. The value of this analytical method in environmental science is demonstrated by the analyses of petrol vapour, car exhaust emissions and the trace organic vapours detected in town air near a busy road. Final examples of the value of this analytical method are the detection and quantification of the gases emitted from crushed garlic and from breath following the chewing of a mint, which demonstrate its potential in food and flavour research. Throughout the paper we stress the advantages of this SIFT method compared to conventional mass spectrometry for trace gas analysis of complex mixtures, emphasizing its selectivity, sensitivity and real-time analysis capability. Finally, we note that whilst the current SIFT is strictly laboratory based, both transportable and portable instruments are under construction and development. These instruments will surely extend the application of this analytical technique into more areas and allow greater exploitation of their on-line and real-time features.
Speckle reduction in ultrasonic images through a maximum likelihood based adaptive filter (2006)

Speckle poses serious problems in the interpretation of ultrasound images. It reduces contrast and resolution, making it difficult to identify the presence of abnormalities in B mode images. Using a recently proposed compound probability density function (pdf) for the statistics of the backscattered ultrasonic signals, an adaptive filter for speckle reduction is implemented and tested on B mode images of a tissue mimicking phantom. Results suggest that the adaptive filter based on a maximum likelihood approach improves the ability to classify targets in images while retaining the details in the original unprocessed image.
A REVIEW ON TECHNIQUES FOR ORAL BIOAVAILABILITY ENHANCEMENT OF DRUGS (2010)

Bioavailability refers to the rate and extent of the drug absorbed in the systemic circulation after administration. Oral delivery, the most convenient mode of drug administration has certain limitations, the most important being the low bioavailability of certain drugs. Drugs having low bioavailability require to be administered at a higher dose as only a small fraction of the administered dose is absorbed in the systemic circulation and reach the target site. Thus, a major amount of the drug is wasted and the unabsorbed drug leads to undesired side effects in the gastrointestinal tract. Various approaches are used for bioavailability enhancement of the orally administered drugs. The present review focuses on the importance of bioavailability, reasons for poor bioavailability and different approaches used for bioavailability enhancement.
English Sects. A History of Nonconformity. W. B. Selbie. (The Home University Library of Modern Knowledge). Henry Holt & Co. Pp. 256. 50 cents. (1915)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Simulation of electrical faults of three phase induction motor drive system (2002)

The simulation of a three-phase induction motor drive system is presented with emphasis on the electrical faults of the inverter and induction motor. Using the basic components of MATLAB SIMULINK toolboxes, the drive system is modeled. An induction motor with mechanical faults is modeled using the winding function method (WFM) and is integrated with the drive model using S-function. The influence of the harmonics produced by synchronous or asynchronous PWM power converters on the induction motor stator current fault-related components is studied. The current waveform patterns for various modes of inverter device failures are investigated. It is shown that the stator current can be used for detection of electrical faults in either the induction motor or the inverter.
7. Semantic primes and cultural scripts in language learning and intercultural communication (2007)

Because meaning is fundamental to language and culture, a practical technique for describing meanings and transposing them across languages has multiple practical applications. This chapter demonstrates several applications of the NSM approach to semantics: as a guide to core vocabulary in the early L2 syllabus, as a means of writing cultural scripts and interpreting cultural key words for language learners, and as the basis for a culture-neutral international auxiliary language. Illustrative material is drawn from English, Russian, and Korean.
Forget me not (2016)

An enzyme called PKM zeta may have a role in long-term memory after all.
Meta-analysis on inoperable pancreatic cancer: A comparison between gemcitabine-based combination therapy and gemcitabine alone (2006)

GEM-based combination therapy may improve the overall survival and palliation in optimal patients with APCa as compared with GEM alone.
The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids (2014)

TDP-43 is an important pathological protein that aggregates in the diseased neuronal cells and is linked to various neurodegenerative disorders. In normal cells, TDP-43 is primarily an RNA-binding protein; however, how the dimeric TDP-43 binds RNA via its two RNA recognition motifs, RRM1 and RRM2, is not clear. Here we report the crystal structure of human TDP-43 RRM1 in complex with a single-stranded DNA showing that RRM1 binds the nucleic acid extensively not only by the conserved β-sheet residues but also by the loop residues. Mutational and biochemical assays further reveal that both RRMs in TDP-43 dimers participate in binding of UG-rich RNA or TG-rich DNA with RRM1 playing a dominant role and RRM2 playing a supporting role. Moreover, RRM1 of the amyotrophic lateral sclerosis-linked mutant D169G binds DNA as efficiently as the wild type; nevertheless, it is more resistant to thermal denaturation, suggesting that the resistance to degradation is likely linked to TDP-43 proteinopathies. Taken together all the data, we suggest a model showing that the two RRMs in each protomer of TDP-43 homodimer work together in RNA binding and thus the dimeric TDP-43 recognizes long clusters of UG-rich RNA to achieve high affinity and specificity.
Diffusion in Sugar Solutions. IV. The Onsager Diffusion Coefficients for Glucose Diffusing in Sucrose Solutions (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiffusion in Sugar Solutions. IV. The Onsager Diffusion Coefficients for Glucose Diffusing in Sucrose SolutionsF. E. Weir and Malcolm DoleCite this: J. Am. Chem. Soc. 1958, 80, 2, 302–306Publication Date (Print):January 1, 1958Publication History Published online1 May 2002Published inissue 1 January 1958https://pubs.acs.org/doi/10.1021/ja01535a013https://doi.org/10.1021/ja01535a013research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Primary Liver Leiomyosarcoma - Mimicking Liver abscess (2002)

Primary hepatic leiomyosarcoma is very rare with only sporadic cases reported. The usual clinical presentation is hepatomegaly or epigastric mass, which is commonly associated with abdominal pain or body weight loss. We reported a 60-year-old man who presented with intermittent low grade fever and right upper quadrant pain. Dynamic CT scan of liver revealed a big mass in right lobe of liver, which showed wall and internal septa enhancement in arterial and portal venous phase images. Although the clinical presentation and CT features suggested a hepatic abscess, a percutaneous aspiration procedure was performed and in favor of tumor growth thereafter. Right lobectomy was then performed. The final pathological report was high grade primary hepatic leiomyosarcoma.
Additive Effect of Stress and Drug Cues on Reinstatement of Ethanol Seeking: Exacerbation by History of Dependence and Role of Concurrent Activation of Corticotropin-Releasing Factor and Opioid Mechanisms (2002)

Stress and exposure to drug-related environmental stimuli have been implicated as critical factors in relapse to drug use. What has received little attention, however, is the significance of interactions between these factors for motivating drug-seeking behavior. To address this issue, a reinstatement model of relapse was used. Footshock stress and response-contingent presentation of an ethanol-associated light cue, acting as a conditioned stimulus (CS), effectively reinstated extinguished responding at a previously active, drug-paired lever in male Wistar rats. When response-contingent availability of the ethanol CS was preceded by footshock, additive effects of these stimuli on responding were observed. Both the individual and interactive effects of footshock and the CS were significantly greater in previously ethanol-dependent than in nondependent rats. Responding induced by the ethanol CS was selectively reversed by the nonselective opiate antagonist naltrexone, whereas the effects of footshock were selectively reversed by the corticotropin-releasing factor (CRF) antagonist d-Phe-CRF<sub>12–41</sub>. However, both agents only partially reversed the enhanced drug-seeking response produced by the interactive effects of stress and the ethanol CS; full reversal required coadministration of d-Phe-CRF and naltrexone. The results document that stress and drug-related environmental stimuli interact to augment the resumption of drug seeking after extinction and suggest that this effect results from concurrent activation of opioid and CRF transmission.