gebhart/patrepeval huggingface dataset:
Malva pseudolavatera Leaf Extract Promotes ROS Induction Leading to Apoptosis in Acute Myeloid Leukemia Cells In Vitro (2020)

<i>Malva pseudolavatera</i> Webb & Berthel. is a plant from the Malvaceae family that has long been included in the human diet due to its various curative effects. Many plant leaf extracts from the various species of <i>Malva</i> genus have been reported to possess anti-cancer properties, however, studies on <i>M. pseudolavatera</i> Webb & Berthel. leaves have documented anti-inflammatory and anti-oxidant effects with no emphasis on their possible anti-cancer potential. The present study explores the anti-cancer properties of <i>Malva pseudolavatera</i> Webb & Berthel. leaf extract on acute myeloid leukemia (AML) cell lines in vitro and deciphers the underlying molecular mechanism. Treatment of AML cell lines with <i>M. pseudolavatera</i> methanolic leaf extract showed a dose- and time-dependent inhibition of proliferation and a dose-dependent increase in apoptotic hallmarks such as an increase in phosphatidylserine on the outer membrane leaflet and membrane leakage in addition to DNA fragmentation. The pro-apoptotic effect was induced by reactive oxygen species (ROS) as well as an upregulation of cleaved poly(ADP-ribose) polymerase (PARP), increase in Bax/Bcl-2 ratio, andrelease of cytochrome-c from the mitochondria. Major compounds of the extract included methyl linolenate, phytol, γ-sitosterol, and stigmasterol as revealed by gas chromatography coupled with mass spectrometry, and amino acids, amino acid derivatives, tiliroside, 13-hydroxyperoxyoctadecadienoic, and quercitrin as detected by liquid chromatography coupled to mass spectrometry.
The neurobiology of social phobia (1996)

Studies in the neurobiology of social phobia have used neuroendocrine, naturalistic and chemical challenges, pharmacological probes, neurotransmitter system measures, peripheral receptor binding and magnetic resonance measures. Studies of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axes have been largely unrevealing; adrenaline, carbon dioxide, caffeine and yohimbine tests have provided mixed results; probe studies using L-dopa, clonidine and fenfluramine have provided some evidence of post-synaptic serotonergic abnormality; studies on platelet and lymphocyte binding have failed to distinguish social phobia from other groups; magnetic resonance imaging and magnetic resonance spectroscopy studies suggest possible differences between patients with social phobia and healthy controls in respect of dopamine, serotonin and second-messenger function. In aggregate, these studies have provided some neurobiological basis for separating social phobia from panic disorder and non-psychiatric healthy controls.
MODEL REDUCTION FOR DISCRETE-TIME SWITCHED LINEAR TIME-DELAY SYSTEMS VIA THE H∞ ROBUST STABILITY (2011)

International audience
Field Test Results of a Beam‐Steered Ground Penetrating Radar Array (2001)

PreviousNext No AccessSymposium on the Application of Geophysics to Engineering and Environmental Problems 2001Field Test Results of a Beam‐Steered Ground Penetrating Radar ArrayAuthors: Neil F. ChamberlainWilliam M. RoggenthenNeil F. ChamberlainSouth Dakota School of Mines and Technology, Rapid City, South Dakota. and William M. RoggenthenSouth Dakota School of Mines and Technology, Rapid City, South Dakota.https://doi.org/10.4133/1.2922899 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Introductory paragraph for this paper is available only in the PDF and GZipped PS filesPermalink: https://doi.org/10.4133/1.2922899FiguresReferencesRelatedDetails Symposium on the Application of Geophysics to Engineering and Environmental Problems 2001ISSN (online):1554-8015Copyright: 2001 Pages: publication data© 2001 Copyright © 2001 The Environmental and Engineering Geophysical SocietyPublisher:Environmental & Engineering Geophysical Society HistoryPublished: 30 Sep 2008 CITATION INFORMATION Neil F. Chamberlain and William M. Roggenthen, (2001), "Field Test Results of a Beam‐Steered Ground Penetrating Radar Array," Symposium on the Application of Geophysics to Engineering and Environmental Problems Proceedings : GP25-GP25. https://doi.org/10.4133/1.2922899 Plain-Language Summary PDF DownloadLoading ...
Konzentrations- und Aktivitätsmessungen wichtiger Serumproteinanteile in Serumkonserven (1984)

Bei zwei verschieden hergestellten Serumkonserven wird der Gehalt an Transportproteinen, Immunglobulinen, Komplementfaktoren und Protease-Inhibitoren bestimmt, wobei sowohl biologische Aktivit&#196;tsmessungen mit chromogenen Substraten als auch immunologische Konzentrationsbestimmungen mit Hilfe des Laser-Nephelometers eingesetzt werden. Der Gehalt aller Faktoren ist erheblich geringer (ca. 50%) als im nativen Plasma bzw. Serum; einige wichtige Proteine fehlen ganz, wie z. B. das Antithrombin III oder der Faktor XIII (fibrinstabilisierender Faktor). Anhand der Befunde wird die Indikation der Serumkonserve als Therapeutikum kritisch diskutiert.
Anomaly detection on bipartite graphs for cyber situational awareness and threat detection (2017)

Data from cyber logs can often be represented as a bipartite graph (e.g. internal IP-external IP, user-application, or client-server). State-of-the-art graph based anomaly detection often generalizes across all types of graphs - namely bipartite and non-bipartite. This confounds the interpretation and use of specific graph features such as degree, page rank, and eigencentrality that can provide a security analyst with rapid situational awareness of their network. Furthermore, graph algorithms applied to data collected from large, distributed enterprise scale networks require accompanying methods that allow them to scale to the data collected. In this paper, we provide a novel, scalable, directional graph projection framework that operates on cyber logs that can be represented as bipartite graphs. This framework computes directional graph projections and identifies a set of interpretable graph features that describe anomalies within each partite.
Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture (2001)

The latency-associated transcript (LAT) is the only abundant herpes simplex virus type 1 (HSV-1) transcript expressed during latency. In the rabbit eye model, LAT null mutants do not reactivate efficiently from latency. We recently demonstrated that the LAT null mutant dLAT2903 induces increased levels of apoptosis in trigeminal ganglia of infected rabbits compared to LAT+ strains (G.-C. Perng, C. Jones, J. Ciacci-Zarella, M. Stone, G. Henderson, A. Yokht, S. M. Slanina, F. M. Hoffman, H. Ghiasi, A. B. Nesburn, and C. S. Wechsler, Science 287:1500-1503, 2000). The same study also demonstrated that a plasmid expressing LAT nucleotides 301 to 2659 enhanced cell survival of transfected cells after induction of apoptosis. Consequently, we hypothesized that LAT enhances spontaneous reactivation in part, because it promotes survival of infected neurons. Here we report on the ability of plasmids expressing different portions of the 5' end of LAT to promote cell survival after induction of apoptosis. A plasmid expressing the first 1.5 kb of LAT (LAT nucleotides 1 to 1499) promoted cell survival in neuro-2A (mouse neuronal) and CV-1 (monkey fibroblast) cells. A plasmid expressing just the first 811 nucleotides of LAT promoted cell survival less efficiently. Plasmids expressing the first 661 nucleotides or less of LAT did not promote cell survival. We previously showed that a mutant expressing just the first 1.5 kb of LAT has wild-type spontaneous reactivation in rabbits, and a mutant expressing just the first 811 nucleotides of LAT has a reactivation frequency higher than that of dLAT2903 but lower than that of wild-type virus. In addition, mutants reported here for the first time, expressing just the first 661 or 76 nucleotides of LAT, had spontaneous reactivation indistinguishable from that of the LAT null mutant dLAT2903. In summary, these studies provide evidence that there is a functional relationship between the ability of LAT to promote cell survival and its ability to enhance spontaneous reactivation.
Preparation and Acid-Base Properties of a Protonated Titanate with the Lepidocrocite-like Layer Structure (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Acid-Base Properties of a Protonated Titanate with the Lepidocrocite-like Layer StructureTakayoshi Sasaki, Mamoru Watanabe, Yuichi Michiue, Yu Komatsu, Fujio Izumi, and Satoshi TakenouchiCite this: Chem. Mater. 1995, 7, 5, 1001–1007Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://doi.org/10.1021/cm00053a029RIGHTS & PERMISSIONSArticle Views2486Altmetric-Citations188LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Recession of an <scp>EB</scp> ‐ <scp>PVD</scp> <scp>YSZ</scp> Coated Turbine Blade by <scp> <scp> CaSO <sub>4</sub> </scp> </scp> and <scp> <scp>Fe</scp> </scp> , <scp> <scp>Ti</scp> </scp> ‐Rich <scp>CMAS</scp> ‐Type Deposits (2011)

An in‐service high‐pressure turbine blade with a columnar, Y 2 O 3 ‐stabilized ZrO 2 ( YSZ ) thermal barrier coating ( TBC ) fabricated by electron‐beam physical vapor deposition was investigated to access the TBC hot corrosion mechanisms during turbine operation. The TBC exhibits a through‐thickness pore filling with anhydrite‐type CaSO 4 . Chemical analysis of the CMAS ‐type particle deposits reveals relatively low SiO 2 but high CaO contents and substantial amounts of Fe 2 O 3 and TiO 2 . The hot corrosion scenario observed at the YSZ column tips involves newly formed CaZrO 3 and the garnet‐type phase Ca 3 (Zr,Mg,Ti) 2 (Fe,Al,Si) 3 O 12 , also known as the mineral kimzeyite. The phase relationships were confirmed in laboratory experiments. CaSO 4 as well as the particle deposits prove to be effective solvents for YSZ introducing distinct solid‐state reactions. The results support the idea of a dual YSZ hot corrosion process. A first stage controlled by a SiO 2 ‐free Ca ‐source, most likely primary CaSO 4 produces a thin CaZrO 3 layer. A second, CMAS ‐type stage providing high concentrations of Fe 2 O 3 , TiO 2 , and SiO 2 favors the formation of kimzeyite. The melting temperature of kimzeyite presumably defines a thermal operation limit for YSZ ‐based TBCs .
The Vilsmeier Reaction of Non‐Aromatic Compounds (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Versatile Human Monitoring System by using PSoC (2014)

Previously, we have developed a human monitoring system, which used 8051 microcontroller. The system has a 3-axis acceleration sensor, a pressure sensor, a humidity sensor, and an electrocardiogram (ECG) circuit. This paper reports the newly developed system by using PSoC (Programmable System-on-Chip), which is a microcontroller with some analog blocks in a single chip. The ECG and the acceleration are sampled at 125 Hz, the others are at 1 Hz by the PSoC. The sampled data are stored on the micro SD card or Static RAM (SRAM), transmitted by a Bluetooth module or USB interface to a PC. The multipurpose I/O pins for addition of some sensors are designed in the system. The multipurpose I/O pins are utilized to control and communicate with an infrared temperature sensor. The system was designed and fabricated by 4-layer printed circuit board (PCB). In comparison with the previous work, the system size was reduced from 85×48×15 mm3 to 50×50×15 mm3, the power consumption without Bluetooth communication was reduced from 45.0 mA to 24.6 mA when the power supply voltage is 3.3 V and the master clock is 48 MHz.
Voltage-Source Series Resonant Zero Current Soft Switching High-Frequency Inverter with PDM Scheme for Induction Heating Roller in Copy Machine. (2003)

This paper presents a voltage source half bridge series load resonant ZCS-PDM high frequency inverter using IGBT power module for the induction-heating roller in copy machines. The steady-state operating principle and unique features of this high frequency inverter with two ZCS-assisted inductive snubbers in series with the active power switch are presented, which can achieve stable zero current soft commutation under pulse density modulated power regulation scheme. The experimental results of cost effective ZCS-PDM inverter treated here are evaluated on basis of computer simulation ones and discussed for the induction-heating roller from a practice point of view
An evaluation of methods for encoding multiple 2D spatial data (2011)

Datasets over a spatial domain are common in a number of fields, often with multiple layers (or variables) within data that must be understood together via spatial locality. Thus one area of long-standing interest is increasing the number of variables encoded by properties of the visualization. A number of properties have been demonstrated and/or proven successful with specific tasks or data, but there has been relatively little work comparing the utility of diverse techniques for multi-layer visualization. As part of our efforts to evaluate the applicability of such visualizations, we implemented five techniques which represent a broad range of existing research (Color Blending, Oriented Slivers, Data-Driven Spots, Brush Strokes, and Stick Figures). Then we conducted a user study wherein subjects were presented with composites of three, four, and five layers (variables) using one of these methods and asked to perform a task common to our intended end users (GIS analysts). We found that the Oriented Slivers and Data-Driven Spots performed the best, with Stick Figures yielding the lowest accuracy. Through analyzing our data, we hope to gain insight into which techniques merit further exploration and offer promise for visualization of data sets with ever-increasing size.
ChemInform Abstract: Powder Synthesis and Characterization of Amorphous Carbon Nitride. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: METATHESIS OF ALLYLSILANES WITH AROMATIC SUBSTITUENTS (1985)

Abstract Bei der Metathese der Allyl‐aryl‐dimethylsilane (I) entstehen die 1,4‐Bis‐(aryl‐dimethylsilyl)‐2‐butene (II).
Fractal Clustering and Knowledge-driven Validation Assessment for Gene Expression Profiling (2005)

DNA microarray experiments generate a substantial amount of information about the global gene expression. Gene expression profiles can be represented as points in multi-dimensional space. It is essential to identify relevant groups of genes in biomedical research. Clustering is helpful in pattern recognition in gene expression profiles. A number of clustering techniques have been introduced. However, these traditional methods mainly utilize shape-based assumption or some distance metric to cluster the points in multi-dimension linear Euclidean space. Their results shows poor consistence with the functional annotation of genes in previous validation study. From a novel different perspective, we propose fractal clustering method to cluster genes using intrinsic (fractal) dimension from modern geometry. This method clusters points in such a way that points in the same clusters are more self-affine among themselves than to the points in other clusters. We assess this method using annotation-based validation assessment for gene clusters. It shows that this method is superior in identifying functional related gene groups than other traditional methods.
PART-1: a novel human prostate-specific, androgen-regulated gene that maps to chromosome 5q12. (2000)

Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate carcinoma. We used cDNA microarrays containing 1500 prostate-derived cDNAs to profile transcripts regulated by androgens in prostate cancer cells. This study identified a novel gene that we have designated PART-1 (prostate androgen-regulated transcript 1), which exhibited increased expression upon exposure to androgens in the LNCaP prostate cancer cell line. Northern analysis demonstrated that PART-1 is highly expressed in the prostate gland relative to other normal human tissues and is expressed as different transcripts using at least three different polyadenylation signals. The PART-1 cDNA and putative protein are not significantly homologous to any sequences in the nonredundant public sequence databases. Cloning and analysis of the putative PART-1 promoter region identified a potential binding site for the homeobox gene PBX-la, but no consensus androgen response element or sterol-regulatory element binding sites were identified. We used a radiation hybrid panel and fluorescence in situ hybridization to map the PART-1 gene to chromosome 5q12, a region that has been suggested to harbor a prostate tumor suppressor gene. These results identify a new gene involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the etiology of prostate carcinogenesis.
Discrete disorder of a whole protein domain in the crystals of tyrosine phenol-lyase (2007)

Tyrosine phenol-lyase (TPL) is a homotetrameric pyridoxal-5’ -phosphate (PLP)-dependent enzyme that catalyses the reversible hydrolytic cleavage of L-tyrosine to phenol and ammonium pyruvate (the β -elimination of L-tyrosine) [R. S. Phillips, T. V. Demidkina, N. G. Faleev, Biochim. Biophys. Acta, 1647 (2003) 167]. As shown previously [D. Milic, D. Matkovic-Calogovic, T. V. Demidkina, V. V. Kulikova, N. I. Sinitzina, A. A. Antson, Biochemistry, 45 (2006) 7544], TPL crystallises in the space group P2(1)2(1)2 with two protein subunits (the catalytic dimer) in the asymmetric unit. In the structure of TPL holoform all protein subunits are in the open conformation. Contrary, in the structure of TPL apoform one protein subunit of the catalytic dimer is in the open conformation, while the other is found in the closed conformation with a significant part of the small protein domain moved toward the large domain. By this domain movement certain catalytically important residues are brought into the active site and the active site cleft becomes closed. We also determined crystal structures of several TPL complexes with bound small molecules which resemble certain enzymatic reaction intermediates. For some of these structures the discrete disorder of the small protein domain was clearly observed in the electron density maps. Namely, the small TPL domain of one protein subunit in the catalytic dimer is present in both closed and open conformation (approximately 50% of each). To our best knowledge, this is the first example of discrete static disorder of a whole protein domain in a protein crystal structure. Modelling and refinement of such disorder will be discussed.
Prognostic Histologic Indicators of Curatively Resected Hepatocellular Carcinomas (2002)

Despite growing information on the clinical behavior of hepatocellular carcinoma, the histologic features associated with survival are not well characterized. Clinical and pathologic data on 425 patients who underwent complete resection for hepatocellular carcinoma were reviewed. Six microscopic features, namely, microvascular invasion, nuclear pleomorphism, mitosis, tumor architecture, growth interface, and tumor necrosis, were examined. Independent predictors of survival were identified and combined into a simple prognostic index. By univariate analysis, microvascular invasion, seen in 51.3% of patients (p <0.001), nuclear grade 3, present in 42% of the cases (p <0.001), and mitosis (p <0.008) were significant predictors of poor survival. Hepatocellular carcinoma with a compact growth pattern had a better prognosis as compared with macrotrabecular (p = 0.014) and acinar (p = 0.051) patterns. By multiple regression analysis, only microvascular invasion (p <0.001) and nuclear grade 3 (p = 0.008) were independent predictors of poor survival. The predictive values of microvascular invasion and nuclear grade allowed the construction of a hepatocellular prognostic index (HPI) whereby HPI = (microvascular invasion status x 0.459) + (nuclear grade x 0.287), with microvascular invasion either absent (0) or present (1) and nuclear grade scored as 1, 2, or 3. Using a cut-off of 0.746 (corresponding to at least nuclear grade 2 with microvascular invasion), two groups could be segregated: fair prognosis (HPI < or = 0.746), with a 50% survival of 5.06 years, and poor prognosis (HPI >0.746) with a 50% survival of 2.71 years (p <0.001). HPI was more discriminating than Edmondson grade, with Edmondson II hepatocellular carcinomas dispersed in both fair and poor prognosis groups. Microvascular invasion and nuclear grade 3 emerge as strong prognostic indicators, and their combination provides adequate prognostic stratification. Practically, hepatocellular carcinoma can be stratified in two groups with regard to prognosis: 1) fair prognosis group (nuclear grade 1 with or without microvascular invasion and nuclear grade 2 without microvascular invasion), and 2) poor prognosis (nuclear grade 2 with microvascular invasion and nuclear grade 3 with or without microvascular invasion). The combination of these histologic parameters provides adequate prognostic stratification.
Analysis of the Trend Toward Fuller Lips Among Fashion Models (2017)

This study examined 50 years of facial images of fashion models to determine a trend toward fuller lips.