gebhart/patrepeval huggingface dataset:
Small Group Socialization Scale (2000)

A Small Group Socialization Scale (SGSS) was developed and tested for reliability and validity. In Study 1, scale items were developed by reviewing research as well as asking group members for open-ended responses regarding fitting in, comfort, certainty, and satisfaction with recent group experiences. Thirty-five items were developed and administered to 445 college student participants. Subsequent reliability and factor analyses resulted in the identification of 14 items reflecting group socialization. In Study 2, the SGSS along with measures of cohesion, consensus, communication satisfaction, and loneliness were administered to 210 small group communication students. Based on acceptable reliability coefficients and correlation coefficients, concurrent validity for the SGSS was demonstrated. Implications for future research are discussed.
Surface plasmon coupling to nanoscale Schottky-type electrical detectors (2010)

We have investigated the near-field coupling of surface plasmons to a titanium/CdS nanowire interface for two different device configurations. A bare aluminum grating on an underlying aluminum layer exhibited the expected stronger electrical signal for perpendicular versus parallel light polarization. An opposite intensity ratio was detected when the grating and the Schottky contact are connected via an aluminum–silica–aluminum sandwich structure. Based upon finite difference time domain device simulations, the enhanced coupling for parallel polarization is attributed to the emergence of a transversal electric wave within the metal–insulator–metal structure.
A Machine Learning-Based Microwave Device Model for Fully Printed VO<sub>2</sub> RF Switches (2021)

Fully printed vanadium dioxide (VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) based Radio Frequency (RF) switches have been recently developed for advanced frequency-reconfigurable RF electronics. A reliable and versatile model for the VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> switches is required for design and simulations in the modern Computer-Aided Design (CAD) tools. This paper proposes a machine learning (ML) based model for VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> RF switches, which is much more time and resource efficient as compared to the traditional device models. The computational efficiency, accuracy and robustness of the proposed model over a frequency range of 30 GHz is demonstrated through an excellent agreement between the modelled and measured results. The comparison between the measured and modelled results demonstrate a mean-square error (MSE) of lower than 5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> and 5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> for the magnitude and phase values over the complete frequency range.
Outcome and Long-Term Side Effects after Synchronous Radiochemotherapy for Childhood Brain Stem Gliomas (2001)

Between 1993 and 1999, 11 children with histologically confirmed diffuse and exophytic brain stem glioma (BSG) were treated with intensive induction chemotherapy and simultaneous external beam irradiation. Chemotherapy was performed according to the German/Austrian Pediatric Brain Tumor Study HIT '91 and included two cycles of ifosfamide (days 1-3), etoposide (days 4-6), methotrexate (days 15 and 22), cisplatin (days 29-31) and cytarabine (days 29-31), separated by a 3-week interval. Maintenance chemotherapy with carmustine, carboplatin and vincristine (8 cycles over a 1-year period) was given in those patients who responded clinically or radiographically to induction chemotherapy. Six of 11 patients showed an objective reduction in tumor size on magnetic resonance imaging and 4 of 11 are alive in good general condition >22, >22, >90 and >92 months, respectively, after diagnosis without radiographic evidence of tumor progression (1 complete remission, 2 partial remissions, 1 stable disease), but suffer from moderate to severe long-term side effects. Three patients died due to disease progression after having achieved a partial remission which lasted 5, 6 and 18 months, respectively, whereas only short-term stabilization was observed in 4 patients who died within 1 year after diagnosis. Acute hematologic toxicity was severe but manageable. This intensive combined modality treatment was toxic but yielded objective responses in more than 50% and long-term survivors in one third of childhood BSG patients.
Zener Diodes as Voltage Reference Sources in Electron Microscopy (1963)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation D. Karl Landstrom; Zener Diodes as Voltage Reference Sources in Electron Microscopy. Rev. Sci. Instrum. 1 October 1963; 34 (10): 1148–1149. https://doi.org/10.1063/1.1718160 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioReview of Scientific Instruments Search Advanced Search |Citation Search
Self-Assembled, Helically Stacked Anionic Aggregates of 2,5,8,11-Tetra-<i>tert</i>-butylcycloocta[1,2,3,4-<i>d</i><i>ef</i>;5,6,7,8-<i>d</i><i>‘</i><i>e</i><i>‘</i><i>f</i><i>‘</i>]bisbiphenylene, Stabilized by Electrostatic Interactions (2002)

Tetraanions of alkyl-substituted derivatives of cycloocta[1,2,3,4-def;5,6,7,8-d'e'f']bisbiphenylene (BPD) and their counter lithium cations self-assemble to form helically stacked assemblies, including a dimer, a trimer, and a tetramer. NMR self-diffusion measurements and unprecedented magnetic shielding effects for the sandwiched lithium cations support their aggregated nature. The D(2)-tetramer assembly is fully characterized by NMR spectroscopy, providing unequivocal evidence for a helix of four tetraanionic BPD layers with an estimated relative twist angle of about 45 degrees and interlayer spacing of ca. 4 A. The barrier for racemization through the in-plane inter-deck rotation is DeltaG(200)= 9.5 +/- 0.2 kcal mol(-1) in the dimer compared to >15 kcal mol(-1) in the tetramer.
Acquisition of probability density functions using a simple acousto-optic system (1999)

We present a simple acousto-optic-based system useful for acquiring time-averaged probability density functions of arbitrary signals. A heuristic analysis is presented as well as experimental results that are shown to agree with theory.
A Monolithic Integrated Circuit for Vertical Deflection in Television Receivers (1975)

The monolithic integrated circuit described here is part of a kit of devices offered for the complete integration of television receiver functions.
Living liver donation improves patient and graft survival in the pediatric population (2018)

The use of LD in children is associated with improved patient and graft survival. The option of LD should be introduced early on in the evaluation of every pediatric patient being evaluated for liver transplant.
Epitaxial stabilization and structural properties of REMnO3 (RE=Dy,Gd,Sm) compounds in a layered, hexagonal ABO3 structure (2007)

RE Mn O 3 (RE=Dy,Gd,Sm) films were deposited on (110) surfaces of single crystalline hexagonal (h-)YMnO3. These films adopted the metastable multiferroic h-REMnO3 structure instead of the stable perovskite structure. Sharp (hh0) diffraction peaks with narrow rocking curves were found for all films. The peak widths increased with increasing size of the rare-earth cation. The c-axis/a-axis lattice parameter decreased/increased monotonically with increasing rare-earth size for these epitaxial films. All films exhibited the following epitaxial relationship {110}REMnO3‖{110}YMnO3;⟨11¯0⟩REMnO3‖⟨11¯0⟩YMnO3. The single-phase hexagonal films were kinetically robust against back transformation to the stable perovskite structure even to thicknesses of 50nm.
Statistical analysis of word-initial voiceless obstruents: Preliminary data (1988)

A statistical procedure for classifying word-initial voiceless obstruents is described. The data set to which the analysis was applied consisted of monosyllabic words starting with a voiceless obstruent. Each word was repeated six times in the carrier phrase "I can say again" by each of ten speakers. Fast Fourier transforms (FFTs), using a 20-ms Hamming window, were calculated every 10 ms from the onset of the obstruent through the third cycle of the following vowel. Each FFT was treated as a random probability distribution from which the first four moments (mean, variance, skewness, and kurtosis) were computed. Moments were calculated from linear and Bark transformed spectra. Data were pooled across vowel contexts for speakers of a given gender and input to a discriminant analysis. Using the moments calculated from the linear spectra, 92% of the voiceless stops were classified correctly when dynamic aspects of the stop were included. Even more important, the model constructed from the males' data correctly classified about 94% of the voiceless stops produced by the female speakers. Classification of the voiceless fricatives when all places of articulation were included in the analysis did not exceed 80% correct when the moments from either the linear or Bark transformed scales were used. However, classification of only the voiceless sibilants was 98% correct when the moments from the Bark transformed spectra were used. As with the stops, the classification model held across gender.
Clinical outcomes and risk factors for severe COVID‐19 in patients with haematological disorders receiving chemo‐ or immunotherapy (2020)

Haematology patients receiving chemo- or immunotherapy are considered to be at greater risk of COVID-19-related morbidity and mortality. We aimed to identify risk factors for COVID-19 severity and assess outcomes in patients where COVID-19 complicated the treatment of their haematological disorder. A retrospective cohort study was conducted in 55 patients with haematological disorders and COVID-19, including 52 with malignancy, two with bone marrow failure and one immune-mediated thrombotic thrombocytopenic purpura (TTP). COVID-19 diagnosis coincided with a new diagnosis of a haematological malignancy in four patients. Among patients, 82% were on systemic anti-cancer therapy (SACT) at the time of COVID-19 diagnosis. Of hospitalised patients, 37% (19/51) died while all four outpatients recovered. Risk factors for severe disease or mortality were similar to those in other published cohorts. Raised C-reactive protein at diagnosis predicted an aggressive clinical course. The majority of patients recovered from COVID-19, despite receiving recent SACT. This suggests that SACT, where urgent, should be administered despite intercurrent COVID-19 infection, which should be managed according to standard pathways. Delay or modification of therapy should be considered on an individual basis. Long-term follow-up studies in larger patient cohorts are required to assess the efficacy of treatment strategies employed during the pandemic.
Efficacy of<i>Bidens pilosa</i>Extract against Herpes Simplex Virus Infection<i>In Vitro</i>and<i>In Vivo</i> (2012)

The development of strains of herpes simplex virus (HSV) resistant to drugs has been reported among the immunocompromised patients. Thus, there is a need to develop new therapeutic agents for HSV infections. We evaluated the anti-HSV activity of Bidens pilosa (B. pilosa), a tropical weed, in tissue culture cells and a mouse model. B. pilosa extract showed potent virucidal activity. It inhibited plaque formation and suppressed virus yield in Vero and RAW 264.7 cells infected with HSV-1 and HSV-2. Both the binding of virus to host cells and penetration of virus into cells were also blocked by B. pilosa. Furthermore, B. pilosa was effective against thymidine kinase-deficient and phosphonoacetate-resistant HSV-1 strains. B. pilosa treatment increased the survival rate of HSV-infected mice and limited the development of skin lesions. Our results indicate that B. pilosa has anti-HSV activity and is thus a potentially useful medical plant for treatment of HSV infection.
Broadband transparent periodic acoustic structures (2013)

The creation of acoustically transparent materials is of interest for enhanced energy focusing in metamaterial lenses, vibration isolation and structure concealment in underwater environments. It has previously been shown that metal pentamode metamaterials may provide water like behavior yet retain enough shear to provide structural stability. This is achieved through a periodic lattice with sub-wavelength cells. The current talk presents a study on the simulated and experimental behavior of other structural materials that operate similar to pentamode composites, which exhibit transparency in underwater conditions. Specifically, we examine a two-dimensional design composed of a honeycomb arrangement of fluid inclusions in a solid polymer background. Materials, designs and simulations are supported through both band structure calculations and transmission modeling of finite slabs of the device. Experiments are performed in a water-filled test tank and broad frequency behavior is examined. Issues such as boundary coupling and omni-directionality are discussed. Work supported by ONR.
Characterization of catalytic centre mutants of macrophage migration inhibitory factor (MIF) and comparison to Cys81Ser MIF (1999)

Macrophage migration inhibitory factor (MIF) displays both cytokine and enzyme activities, but its molecular mode of action is still unclear. MIF contains three cysteine residues and we showed recently that the conserved Cys57-Ala-Leu-Cys60 (CALC) motif is critical for the oxidoreductase and macrophage-activating activities of MIF. Here we probed further the role of this catalytic centre by expression, purification, and characterization of the cysteine-->serine mutants Cys60Ser, Cys57Ser/Cys60Ser, and Cys81Ser of human MIF and of mutants Ala58Gly/Leu59Pro and Ala58Gly/Leu59His, containing a thioredoxin (Trx)-like and protein disulphide isomerase (PDI)-like dipeptide, respectively. The catalytic centre mutants formed inclusion bodies and the resultant mutant proteins Cys57Ser/Cys60Ser, Ala58Gly/Leu59Pro, and Als58Gly/Leu59His were only soluble in organic solvent or 6 m GdmHCl when reconstituted at concentrations above 1 microgram.mL-1. This made it necessary to devise new purification methods. By contrast, mutant Cys81Ser was soluble. Effects of pH, solvent, and ionic strength conditions on the conformation of the mutants were analysed by far-UV CD spectropolarimetry and mutant stability was examined by denaturant-induced unfolding. The mutants, except for mutant Cys81Ser, showed a close conformational similarity to wild-type (wt) MIF, and stabilization of the mutants was due mainly to acid pH conditions. Intramolecular disulphide bond formation at the CALC region was confirmed by near-UV CD of mutant Cys60Ser. Mutant Cys81Ser was not involved in disulphide bond formation, yet had decreased stability. Analysis in the oxidoreductase and a MIF-specific cytokine assay revealed that only substitution of the active site residues led to inactivation of MIF. Mutant Cys60Ser had no enzyme and markedly reduced cytokine activity, whereas mutant Cys81Ser was active in both tests. The Trx-like variant showed significant enzyme activity but was less active than wtMIF; PDI-like MIF was enzymatically inactive. However, both variants had full cytokine activity. Together with the low but nonzero cytokine activity of mutant Cys60Ser, this indicated that the cytokine activity of MIF may not be tightly regulated by redox effects or that a distinguishable receptor mechanism exists. This study provides evidence for a role of the CALC motif in the oxidoreductase and cytokine activities of MIF, and suggests that Cys81 could mediate conformational effects. Availability and characterization of the mutants should greatly aid in the further elucidation of the mechanism of action of the unusual cytokine MIF.
Professor Fiona Lyng (2013)

Dr. Lyng is the manager of the Radiation and Environmental Science Centre in DIT.\nShe obtained a BSc (Physics and Chemistry, 1st Class honours) from Trinity College Dublin / Dublin Institute of Technology in 1991. PhD (Radiation Biology / Electron Microscopy) in 1995 from University College Dublin. Worked at Michigan State University as part of PhD studies. Postdoctoral fellowship (awarded by the Ernst Schering Research Foundation) at the Synchrotron Radiation Department, Daresbury Laboratory, UK, from 1995 to 1998, studying cell signalling pathways by unique microscopical techniques utilising synchrotron radiation. Also deputy station manager of the confocal microscopy facility at Daresbury Laboratory which involved the training of users and upgrading and maintaining the facility. Worked at the Cellular Physiology Research Unit in University College Cork from 1998 to 1999 continuing research from Daresbury Laboratory and commissioning and training users on a Bio Rad MRC 1024 confocal microscope. Awarded a DIT postdoctoral fellowship in 1999 and an Arnold Graves Fellowship in 2000. RESC Centre Manager since 2003 with responsibility for approx. 12 postgraduate students and 4 postdoctoral researchers. Currently PI on 5 grants and over 75 peer reviewed publications. Have supervised 13 PhD projects and 2 MPhil projects to completion. Awarded Honorary Professorship of DIT, Feb 2012.\nCurrent research interests are in non-targeted effects of ionisng and non ionising radiation: genomic instability (heritable damage in the distant progeny of irradiated cells) and the bystander effect (release of a signal by irradiated cells that can affect unexposed cells). Also interested in the use of vibrational spectroscopy for disease diagnosis.
Effect of the Carboxylate Salt on the CON Bond Homolysis of SG1‐Based Alkoxyamines (2008)

Alkoxyamines and persistent nitroxides are important regulators of the nitroxide mediated radical polymerization (NMP). Since the polymerization time decreases with increasing values of the homolysis rate constant (kd) for the C--ON bond between the polymer chain and the nitroxide moiety, the factors influencing kd are of considerable interest. Environmentally friendly polymerization methods, such as NMP in emulsion medium, have now been developed. The success of the polymerization depends not only on the strength of the C--ON bond but also on the solubility of the initiator/controller alkoxyamines, which control the nucleation. Various salts of SG1-based alkoxyamines (S+-OOCCMeH-SG1) labelled 1 a-f, where S+=Li+ (a), Na+ (b), K+ (c), nBu3HN+ (d), NH4+ (e), and nBu4N+ (f) are prepared, all of which are soluble in most organic solvents (e.g. pentane, dichlomethane, benzene, ethanol, etc.) as well as in water. Their kd values, which are measured in tert-butylbenzene, reveal unexpected behaviors depending on the diastereoisomers. For the RR/SS diatereoisomers (i.e. slowly homolyzing isomers), kd was not found to be sensitive to any of the salts, whereas for the RS/SR diastereoisomers (i.e. quickly homolyzing isomers), kd is observed to decrease to a greater or lesser extent depending on the type of salt. The conformations of the diastereoisomers of several salts are determined by means of DFT calculations, and the orbital interactions are studied by natural bond orbital (NBO) analysis.
Familial associations of female breast cancer with other cancers (2017)

Familial risks of breast cancer (BC) are well established but whether BC clusters with other, i.e. discordant, cancers is less certain but of interest for the identification of common genetic and possible environmental factors contributing to a general cancer susceptibility. We apply a novel approach to search for familial associations of BC with other (discordant) cancers based on the Swedish Family-Cancer Database. Relative risks (RRs) were calculated for BC in families with increasing numbers of patients with discordant cancer X, and conversely, familial RRs for cancer X in families with increasing numbers of BC patients. Joint p-values were calculated from independent analyses. The total number of familial BCs was 12,266, 14.9% with one first-degree relative with BC and 1.2% with at least 2 affected relatives. Ovarian and prostate cancers showed the strongest associations with BC (p-value <10<sup>-11</sup> ). The p-value for melanoma was <10<sup>-6</sup> , for stomach and male colorectal cancer <2.5 × 10<sup>-6</sup> , for cancer of unknown primary <2.5 × 10<sup>-5</sup> and for lung cancer <5 × 10<sup>-5</sup> . Significance level <5 × 10<sup>-4</sup> was reached with pancreatic cancer. The remaining associations (p < 0.0025) included thyroid, endometrial, testicular, eye cancers (uveal melanoma), nervous system and endocrine tumors and non-Hodgkin lymphoma. The RR for BC increased by increasing numbers of patients with any cancer in family members and it reached 1.62 when three or more family members were affected. The results suggest that BC shares susceptibility with a number of other cancers. This might alert genetic counselors and challenge approaches for gene and gene-environment identification.
Stabilization and the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition. (1981)

Treatment of epithelial BSC-1 cells with low concentrations of the detergent Brij 58 results in partial or complete removal of the plasmalemma and partial extraction of internal membrane-bound organelles without causing massive release of "cytosolic" proteins from the cytoplasmic ground substance. Stereoscopic high-voltage electron microscopy of such extracted and fixed cells demonstrates a system of slender (4-20 nm) strands in a three-dimensional "microtrabecular" arrangement similar to that observed in unextracted whole-mount preparations. Extraction of Brij-extracted cells with Triton X-100 dissolves many of the microtrabecular strands, leaving, as a more stable structure, a characteristic cytoskeletal network composed of various filaments and microtubules. Two-dimensional polyacrylamide gel electrophoresis of 35S-labeled polypeptides performed concurrently with the morphological studies demonstrates that Triton extraction of Brij-extracted cells releases a large number of polypeptides. This release parallels the loss of structural components observed by electron microscopy. Labeling of Brij-extracted cells with heavy meromyosin subfragment 1 decorates actin filaments with characteristic arrowhead complexes which are readily visualized only after subsequent Triton extraction. These observations support the concept that many cytoplasmic proteins are structure-bound and, in addition to the components comprising the cytoskeleton, are structure-forming. We conclude that a metastable association of various proteins of the cytoplasmic ground substance exists whose morphological integrity is maintained, at lest temporarily, after removal of the plasmalemma in solutions containing Brij 58.