gebhart/patrepeval huggingface dataset:
Nanoparticle albumin-bound (Nab) paclitaxel (P) in combination with bevacizumab (B) with and without gemcitabine (G): Early experience at the Braman Family Breast Cancer Institute (2006)

10748 Background: Nab-P improves outcomes when compared against single agent cremophor-based P, as does the addition of bevacizumab or gemcitabine to the same agent. There are no available data regarding combinations of Nab-P with B and/or G. Ongoing investigational efforts are evaluating various doublets with these agents, but, to the best of our knowledge, not all 3 of them in the same regimen. All drugs are currently FDA-approved in the treatment of breast cancer. Methods: Review of single-institution experience, evaluating safety and preliminary evidence of activity with the use of Nab-P and B with and without G in heavily pretreated her2neu negative metastatic breast cancer patients. Assessment of response was undertaken by the investigators independently of treating physician. RECIST criteria were used. Three patients received Nab-P and B at the following doses: Nab-P 100 mg/m 2 , B 10 mg/kg every 2 weeks, and 2 patients received all 3 drugs as follows: Nab-P 100 mg/m 2 , G 1,000 mg/m 2 , B 10 mg/kg every 2 weeks. Results: Five women have been evaluated. Median age was 51 (range 34–69). Two patients had hormone-receptor positive disease and 3 had ER/PR/Her2neu-negative cancer. Prior number of regimens was 3 (range 2–7). Four patients had been treated with a taxane. One received both paclitaxel and docetaxel, and 3 docetaxel only. A median of 5 cycles have been administered (range 3–9). First-cycle grade 3/4 toxicity was seen in only one patient who had a baseline grade 2 thrombocytopenia that progressed to grade 3. The thrombocytopenia resolved without requiring transfusion and without any hemorrhagic complication. Another patient developed grade 2 peripheral neuropathy. Two patients are not yet assessable for response. At time of first evaluation 1 patient had progressive disease (Nab-P, B; 7 prior lines of treatment), one had stable disease (Nab-P, B, G; 3 prior lines of therapy, including docetaxel), and 1 had a partial response (Nab-P, B, G; 2 prior therapies, including docetaxel). Conclusions: These very preliminary data suggest that Nab-P in combination with B with and without G is a safe regimen and formal Phase I/II trials are being developed to confirm its clinical activity. [Table: see text]
Characterisation and performance of high power packaged devices (2003)

This paper presents a measurement system that combines the capabilities of a vector network analyser, load and source pull and time domain measurement in a single test-bench. The system is based upon the microwave transition analyser (MTA) and a high power test fixture which was designed in-house. The user may optimise the load and source impedance for best desired performance, output power, gain or efficiency. The results achieved using the nonlinear measurement system are detailed, along with the measurement system set up and large-signal calibration.
Enhanced Withdrawal of Polychlorinated Biphenyls: A Comparison of Colestipol, Mineral Oil, Propylene Glycol, and Petroleum Jelly with or Without Restricted Feeding , (1989)

Meat type chickens were fed a commercial mixture of polychlorinated biphenyl (PCB), Aroclor 1254, at 10 ppm for 14 days, then treated for 21 days to hasten the withdrawal of PCB with either mineral oil (MO), petroleum jelly (PJ), propylene glycol (PG), or colestipol (CO) at 5% of the diet, or at 10% of the diet when restricted to 50% of control intake (50% FR). Whole carcass analyses for PCB revealed that MO + 50% FR reduced PCB to 1.91 mg/bird, or 32% of the body burden (5.96 mg) in nontreated chickens previously fed PCB, whereas those restricted in feed intake by 50% (50% FR) had almost no change (6.44 mg/bird) in body burdens. The PJ, PG, and CO in combination with 50% FR reduced body burdens of PCB to 47, 57, and 77%, respectively, of the control value. When treated with MO, PJ, PG, or CO alone (no 50% FR), chickens had body burdens reduced to only 67 to 90% of control, depending on th compound. Thus, feed restriction was necessary for the MO and PJ to have their greatest effect. Carcass lipid values and body weight gains were markedly reduced by the feed restriction. The CO reduced carcass lipid in nonrestricted chickens by 30%.
Elastic therapeutic tape: do they have the same material properties? (2016)

[Purpose] Elastic therapeutic tape has been widely used for rehabilitation and treatment of sports injuries. Tapes with different elastic properties serve different treatment purposes with inappropriate tension reducing tape effectiveness. Many tapes are available in the market, but studies on tape properties are limited. The aim of this study was to examine the material properties of elastic therapeutic tape. [Subjects and Methods] Brands of elastic therapeutic tape included KinesioTex(®), ATex, Mueller, 3M, and ThaiTape. The Material Testing System Insight(®) 1 Electromechanical Testing Systems was used to apply a tensile force on elastic therapeutic tape. Ten specimens of each brand were tested. Stress, load, and Young's modulus at 25%, 50%, 75%, 100%, and maximum point were collected. One-way analysis of variance with post hoc testing was used to analyze tape parameters. [Results] Maximum elongation and Young's modulus at all percentages were significantly different between brands. There were no differences in maximum load and maximum stress. [Conclusion] Mechanical properties are different for commercial elastic therapeutic tapes. Physiotherapists and other clinicians should be aware of mechanical tape properties to correctly apply kinesio tape.
A High Performance Horn for Large Format Focal Plane Arrays (2007)

We describe the design and performance of an easy to machine horn which exhibits excellent beam circularity and low cross polarisation over a relatively large bandwidth. No grooves are machined into the horn walls but, alternatively, flare angle discontinuities are generated along the horn profile. In other words, the horns will have several flare angles or sections instead of one. For example, if the horn consists of two flare angles, it could then be considered as a conventional Potter horn. As can be seen below, even with this simple design, excellent radiation patterns can be obtained over 15% bandwidth. The bandwidth could be further increased by adding more subsections with 30% bandwidth obtained when the profile is based on 4 sections. The operation of the horn is based on generating higher order modes at the correct amplitude ratio and phase with respect to the incident TE11 mode in the circular waveguide, which is achieved by accurate determination of the magnitude and location of the flare steps. This in turn yields a field distribution at the horn aperture that has low sidelobes and cross polarization in the radiation pattern. A key component in the design package is the optimization software that searches for the correct magnitude and location of the flare discontinuities. We have generated a software package based on the combination of modal matching, genetic algorithm (GA) and simplex optimization. The genetic code is first used to locate the proximity of the global minimum. The set of parameters obtained are then used as a starting point for the simplex method, which refines the parameters to the required accuracy. We shall illustrate our method by showing radiation patterns using two and three step discontinuities and also patterns for a spline profiled horn based on work by other investigators who used different optimization techniques.
Interaction of femtosecond filaments in sapphire (2010)

The interaction of two femtosecond filaments has been studied in single-crystal sapphire at small crossing angles 1.2° ÷5°. Regular multifilament pattern (MFP) can be formed in the overlapping area of two beams, which depends on the pulse energy, crossing angle, and phase difference. As a special realization of MFP, formation of a single filament from two different pump beams was for the first time observed. The number of filaments in the MFP depends on the number of the interference maxima in overlapping area, whose power exceeds critical power for self-focusing. We demonstrate control of multifilament pattern, changing the phase shift between the interacting beams. Attraction and repulsion of the filaments is observed in vicinity of the overlapping region for both in- and counter-phase beams depending on the position Z along the propagation axis. Transformation of near- and far-field images of the single filament, formed by two pump beams, and spectra of its axial emission have been studied depending on the filament length. It has been shown that four-wave mixing plays a major role in forming the axial emission spectrum.
STUDIES ON INFLAMMATION (1961)

The mechanism, whereby histamine and serotonin increase the permeability of blood vessels, was studied in the rat by means of the electron microscope. The drugs were injected subcutaneously into the scrotum, whence they diffused into the underlying (striated) cremaster muscle. An intravenous injection of colloidal HgS was also given, in order to facilitate the identification of leaks by means of visible tracer particles. After intervals varying from 1 minute to 57 days the animals were killed; the cremaster was fixed, embedded in methacrylate, and examined with the electron microscope. One to 12 minutes after the injection, the blood vessels of the smallest caliber (3 to 5 micra as measured on electron micrographs) appeared intact. Numerous endothelial openings were present in blood vessels with a diameter of 7 to 8 micra or more. These gaps were 0.1 to 0.8 micra in width; portions of intercellular junctions were often present in one or both of the margins. The underlying basement membrane was morphologically intact. An accumulation of tracer particles and chylomicra against the basement membrane indicated that the latter behaved as a filter, allowing fluid to escape but retaining and concentrating suspended particulate matter of the size used. Uptake of tracer particles by endothelial vesicles was minimal. Phagocytosis by endothelial cells became more prominent at 3 hours, but as a secondary occurrence; the pericytes were actively phagocytic at all stages. At the 3-hour stage no leaks were found. The changes induced by histamine and serotonin were indistinguishable, except that the latter was more potent on a mole-to-mole basis. In control animals only small accumulations of tracer particles were found in the wall of a number of blood vessels. With regard to the pathogenesis of the endothelial leaks, the electron microscopic findings suggested that the endothelial cells become partially disconnected along the intercellular junctions. Supporting evidence was provided at the level of the light microscope, by demonstrating-in the same preparation-the leaks with appropriate tracer particles(1), and the intercellular junctions by the silver nitrate method. The lipid nature of the chylomicron deposits observed in electron micrographs was also confirmed at the level of the light microscope, using cremasters fixed in formalin and stained in toto with sudan red.
CDC Tracking Enterovirus D-68 Outbreak Causing Severe Respiratory Illness in Children in the Midwest (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigations of Biomass Pretreatment and Submerged Fixed-bed Fermentation (2012)

To improve the MixAlco process and biomass pretreatment, five studies were conducted. Three studies related to fermentation, whereas the other two investigated the effectiveness of shock tube pretreatment (STP) coupled with oxidative lime pretreatment (OLP).\n\nIn the first study, the constant-selectivity assumption used in the continuum particle distribution model (CPDM) was determined to be invalid. During a 32-day batch fermentation, selectivity increased from 0.10 to 0.40 g acid/g non-acid volatile solid (NAVS) digested. Future revisions to CPDM should incorporate a non-constant selectivity term. \n\nIn the second study, a revised procedure was developed to provide a more accurate determination of moisture content. Conventional drying at 105 degrees C allowed product acids to vaporize with water, which introduced errors. Using the revised procedure, calcium hydroxide or sodium hydroxide was added to samples at a concentration of 0.01 g base/g sample, which retained acids in the sample. The mass of additional retained material closely matched that of the additional retained acid. \n\nThree related studies involving biomass pretreatment were performed. In the first, recommended parameters for pretreating sugarcane bagasse with OLP and STP were determined. Recommended OLP parameters were 130 degrees C, 6.9-bar O2, and 2-h duration. The effects of solids concentration, liquid fill volume, particle size, type of shotgun shell, number of shocks, and pretreatment order were investigated. Liquid fill volume, particle size, type of shotgun shell, and pretreatment order were significant variables, whereas solids concentration and number of shocks were not. \n\nRecommended OLP parameters were used as a basis for an additional experiment. To simulate industrial-scale pile fermentation, fixed-bed batch fermentation of OLP + STP sugarcane bagasse was performed in 1-L PVC fermentors. Rubber mulch was used as a structural support material to prevent filter plugging, which had been reported in previous work. After 42 d, acid concentration reached 8 g/L with yield approximately 0.1 g acid/g NAVS fed. Poor fermentation performance was caused by short solid-liquid contact time and poor pH control. \n\nA third biomass pretreatment experiment investigated the potential of pretreated corn stover as a potential ruminant feed. Five samples (raw, OLP, STP, OLP + STP, and STP + OLP) were analyzed for composition and in vitro digestibility. STP followed by OLP increased neutral detergent fiber (NDF) digestibility from 49.3 to 79.0 g NDF digested/100 g NDF fed. On an organic matter basis, STP + OLP corn stover plus water-soluble extractives had a total digestible nutrients (TDN) of 74.9, nearly reaching corn grain at 88.1.
Characterization stability and refolding of recombinant hirudin (1991)

A recombinant variant of hirudin, the blood-clotting inhibitor of the leech Hirudo medicinalis, has been characterized employing spectroscopic and hydrodynamic techniques. Conditions have been defined for efficient reconstitution of the native, disulfide-bonded inhibitor from completely unfolded, reduced polypeptide chains.



The spectral properties of the native inhibitor are consistent with previous results on the solution structure of hirudin. Extremely low circular dichroism in the far ultraviolet () indicates a very low content of regular secondary structure. Although both tyrosine residues of the recombinant inhibitor titrate around pH 10.6, typical for solvent-exposed tyrosines, fluorescence emission and near-ultraviolet circular dichroism suggest that at least one of the tyrosines is partially shielded from solvent quench, and immobilized in an asymmetric environment. Reversible thermal unfolding of hirudin around 65° C is indicated by the disappearance of its dichroic absorption in the near ultraviolet and by a fourfold increase in ellipticity at 225 nm. The transition can be approximated by a two-state model with a transition enthalpy of Hvan't Hoff= 159 kJ/mol and a transition entropy of 464 J · mol−1· K−1. Reduced hirudin at room temperature is largely unfolded and inactive as an inhibitor of thrombin assayed with a low-molecular-mass substrate. Refolding and reoxidation are observed at alkaline pH in the presence of a mixture of glutathione and glutathione disulfide. Spectroscopy, thrombin inhibition, and reversed-phase HPLC indicate reconstitution yields close to 100% and that the reconstituted inhibitor is identical to the native starting material.
Bacterial aggregation and biofilm formation in a vortical flow (2012)

Bacterial aggregation and patchiness play an important role in a variety of ecological processes such as competition, adaptation, epidemics, and succession. Here, we demonstrate that hydrodynamics of their environment can lead to their aggregation. This is specially important since microbial habitats are rarely at rest (e.g., ocean, blood stream, flow in porous media, and flow through membrane filtration processes). In order to study the dynamics of bacterial collection in a vortical flow, we utilize a microfluidic system to mimic some of the important microbial conditions at ecologically relevant spatiotemporal scales. We experimentally demonstrate the formation of "ring"-shaped bacterial collection patterns and subsequently the formation of biofilm streamers in a microfluidic system. Acoustic streaming of a microbubble is used to generate a vortical flow in a microchannel. Due to bacteria's finite-size, the microorganisms are directed to closed streamlines and trapped in the vortical flow. The collection of bacteria in the vortices occurs in a matter of seconds, and unexpectedly, triggers the formation of biofilm streamers within minutes. Swimming bacteria have a competitive advantage to respond to their environmental conditions. In order to investigate the role of bacterial motility on the rate of collection, two strains of Escherichia coli bacteria with different motilities are used. We show that the bacterial collection in a vortical flow is strongly pronounced for high motile bacteria.
Dynamic models of production with multiple operations and general processing times (1997)

Traditional integer programming model formulations for job-shops and flow-shops do not easily account for characteristics common to high-technology manufacturing such as high-volume semiconductor manufacturing. These characteristics are: (1) products (wafers) are processed by the same machine type more than once during the operation sequence, (2) many lots of similar type are run, and (3) there can be multiple machines of the same type. In this paper, we present two new integer programming formulations which easily account for these characteristics. The approach is based on restricting the allowed domain of events for the start of lot processing. The first model restricts production starts to the beginning of a planning time period. The second model uses a special time grid at each operation with width equal to the processing time, and allows starts to be scheduled at the grid points. In an example problem replicating a high-volume wafer fabrication process, it is shown that it is computationally practical to obtain solutions for the restricted start models where it is not computationally possible for the traditional integer programming model formulations.
Automated Tagging to Enable Fine-Grained Browsing of Lecture Videos (2011)

Many universities offer distance learning by recording classroom lectures and making them accessible to remote students over the Internet. A university's repository usually contains hundreds of such lecture videos. Each lecture video is typically an hour's duration and is often monolithic. It is cumbersome for students to search through an entire video, or across many videos, in order to find portions of their immediate interest. It is desirable to have a system that takes user-given keywords as a query and provides a link to not only the corresponding lecture videos but also to the section within the video. In order to do this, lecture videos are sometimes tagged with meta-data to enable easy identification of the different sections. However, such tagging is often done manually and is a time-consuming process. In this paper, we propose a technique to automatically generate tags for lecture videos. This is based on generating speech transcripts automatically using a speech recognition engine and automatic indexing and search of the transcripts. We also describe our system implemented for easily browsing through a lecture video repository. Our system takes keywords from users as a query and returns a list of videos as the results. In each video of the retrieved list, the portion of the video that matches the query is highlighted so that users can easily navigate to that location within the video. Following the approach and using open source tools mentioned in the paper, a lecture video repository can provide features for users to access the content required by them easily. We used open source libraries available for speech recognition and text search purposes. We have performed experiments to test the performance of our system, we have achieved a recall of 0.72 and an average precision of 0.84 as video retrieval results.
A Novel Deep Learning System with Data Augmentation for Machine Fault Diagnosis from Vibration Signals (2020)

In real engineering scenarios, it is difficult to collect adequate cases with faulty conditions to train an intelligent diagnosis system. To alleviate the problem of limited fault data, this paper proposes a fault diagnosis method combining a generative adversarial network (GAN) and stacked denoising auto-encoder (SDAE). The GAN approach augments the limited real measured data, especially in faulty conditions. The generated data are then transformed into the SDAE fault diagnosis model. The GAN-SDAE approach improves the accuracy of the fault diagnosis from the vibration signals, especially when the measured samples are few. The usefulness of this method is assessed through two condition-monitoring cases: one is a classic bearing example and the other is a more general gear failure. The results demonstrate that diagnosis accuracy for both cases is above 90% for various working conditions, and the GAN-SDAE system is stable.
An adaptive approach in digital distance protection (1991)

Adaptive distance protection can be obtained by forming an adaptive control system, and rules about information, functions, and time sequence must followed in its design. Three adaptive methods are suggested to deal with the following problems: (1) the effect of frequency variation, (2) the effect of fault resistance in single-phase-to-ground faults, and (3) the effect of power swings in power systems. A prototype of digital distance protection has been designed and tested on a 500 kV dynamic power system model. Tests results show that the performance of distance protection can be improved by the adaptive methods.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>