gebhart/patrepeval huggingface dataset:
Non-invasive measurement of instantaneous forces during aquatic locomotion: a case study of the bluegill sunfish pectoral fin (2007)

Swimming and flying animals generate unsteady locomotive forces by delivering net momentum into the fluid wake. Hence, swimming and flying forces can be quantified by measuring the momentum of animal wakes. A recently developed model provides an approach to empirically deduce swimming and flying forces based on the measurement of velocity and vortex added-mass in the animal wake. The model is contingent on the identification of the vortex boundary in the wake. This paper demonstrates the application of that method to a case study quantifying the instantaneous locomotive forces generated by the pectoral fins of the bluegill sunfish (Lepomis macrochirus Rafinesque), measured using digital particle image velocimetry (DPIV). The finite-time Lyapunov exponent (FTLE) field calculated from the DPIV data was used to determine the wake vortex boundary, according to recently developed fluid dynamics theory. Momentum of the vortex wake and its added-mass were determined and the corresponding instantaneous locomotive forces were quantified at discrete time points during the fin stroke. The instantaneous forces estimated in this study agree in magnitude with the time-averaged forces quantified for the pectoral fin of the same species swimming in similar conditions and are consistent with the observed global motion of the animals. A key result of this study is its suggestion that the dynamical effect of the vortex wake on locomotion is to replace the real animal fin with an ;effective appendage', whose geometry is dictated by the FTLE field and whose interaction with the surrounding fluid is wholly dictated by inviscid concepts from potential flow theory. Benefits and limitations of this new framework for non-invasive instantaneous force measurement are discussed, and its application to comparative biomechanics and engineering studies is suggested.
Thermal Performance Evaluation and Enhancement for an Automotive Wireless Application Incorporating Multiple Dynamic Heat Sources (2007)

A detailed transient thermal study for a Remote Keyless Entry System with dynamic heat sources is performed using numerical simulations. The SmartMOS-type device is packaged in a 54 lead SOIC (small outline IC) package with an exposed copper slug. The package is attached to a 4-layer PCB with thermal vias embedded in the board. The challenge resides in the transient thermal interaction between several dynamic heat sources (channels), activated in a sequential fashion following different powering profiles and patterns. The main purpose of the device is to wirelessly provide a communication path between the remote and the receiver placed in the car, so the distance and the signal strength between the two are paramount for an optimal operation. The signal strength is directly associated with the voltage (and associated powering) levels. Several operating scenarios are evaluated by modifying the system design (thermal via pattern) and varying both power dissipation and duration levels. The study starts with just one channel dissipating power, followed by activating the entire dynamic system comprised of six channels dissipating each powers reaching up to 22W at different time intervals. The transient thermal behavior of each source is analyzed during the process. Results indicate that the system dissipating over 14V exceeds the thermal budget (150C) after only 3 powering cycles. Based on the analysis of the complex temperature fields for the multiple dynamic source system, the authors identify alternative power profiles to improve the thermal performance of the overall wireless system, by splitting the power in selective channels and by modifying the power sequence. Several additional cases are further investigated, and the optimized power profiles indicate that they satisfy the thermal budget under various operating conditions and several multiple cycles, while still maintaining the device voltage at 14V levels. A thorough study of the transient patterns and needed system improvements are included.
Recent progress in soft-templating of porous carbon materials (2012)

Mesoporous carbons synthesized via a soft-templating approach have attracted much attention due to their easy synthesis and facile control over the derived pore structure. In analogy to soft-templating approaches for mesoporous metal oxides, their synthesis is based on a sequence of forming supramolecular arrangements of precursor molecules with the soft templates, stabilization of the precursor framework by polymerization and finally the removal of the templates. Using micelles of amphiphilic block-copolymers as templates, facile control over the morphology and size of mesopores can be achieved by e.g. controlling size, composition, and concentration of the template polymers or composition and degree of polymerization of the precursor. Moreover, soft templating approaches can be extended to obtain also carbon materials with hierarchical meso- and macroporosity. The additional macroporosity either can result from templating by polymer latex or is induced via macrophase separation. In this review, we describe recent progress and examples in the synthesis and application of mesoporous carbon materials based on soft-templating approaches. Moreover, we reiterate fundamental principles of self-aggregation, highlight proposed synthesis mechanisms and present means of controlling pore size, also in hierarchical meso–macroporous carbon materials.
Energy Efficient Data Gathering Schema for Wireless Sensor Network: A Matrix Completion Based Approach (2019)

In this paper, we seek to address the data gathering in the continually growing Wireless Sensor Networks (WSNs) with the intention to save the nodes' energy. In order to address usual WSN problems, such as data losses, collisions and retransmissions, a twofold data compression pattern is proposed. We consider that a restricted number of sensor nodes are selected to be active and represent the whole network, while the rest of nodes remain idle and do not participate at all in the data sensing and transmission. Furthermore, the set of active nodes' readings is efficiently reduced, in each time slot, according to the cluster scheduling. Relying on the existing Matrix Completion techniques, the sink node is unable to recover the entire data matrix due to the existence of completely empty rows that correspond to the inactive nodes, which can be considered as absent nodes for a very long period, or nodes that do not exist at all. Thereby, we propose a complementary interpolation technique, based on a minimization problem that benefits from nodes inter-correlation, to guarantee the reconstruction of all the empty rows, despite their large number. The simulations confirm the efficiency of the proposed approach and show that it outperforms the existing one by up to 70.101% of Normalized Mean Absolute Error on all missing elements, when the number of active nodes is of about 10% of the total number of nodes.
Variability Expression within the Context of UML (2011)

Time-to-market is one of the most severe constraints imposed on today’s software engineers. The increasing complexity of systems has also shortened the time available for designing them. Several solutions have therefore been proposed to decrease the time and cost of producing applications. This chapter presents the product line paradigm as an effective solution for managing both the variability of products and their evolutions. The product line approach calls for designing a generic and parameterized model that specifies a family of products. It is then possible to instantiate a member of that family by specializing the “parent” model or “framework.” In describing the latter, designers need to explicitly model variability and commonality points among applications. The following discussion explains in detail how UML models express these different requirements. We then describe specific extensions of UML profiles and the way they are used in various product line methodologies.Request access from your librarian to read this chapter's full text.
Absorption Spectra of Excitons in Alkali Halides in the Vacuum-Ultraviolet Region (1973)

On the basis of the localized excitation model, characteristic absorption spectra of excitons in alkali halides in the range of photon energy around 20 eV corresponding to the n p 6 → n p 5 n ' s and n p 6 → n p 5 n d excitations of alkali ions are theoretically treated by using methods developed in the ligand field theory. By assuming reasonable values of Slater integrals, the spin-orbit interaction constant and the ligand-field strength, the observed positions including their chemical shifts and the relative intensities of five absorption peaks called A , B , C , D and E in RbX(X=F, Cl, Br, I) are explained satisfactorily. In constant to the case of the band picture, the excited d -orbital responsible for the absorption of RbX is shown to be mainly of the d γ character, although mixing of the p 5 s , p 5 d ε and p 5 d γ configurations is appreciable.
High-dose growth hormone treatment of short children born small for gestational age. (1996)

The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg. At the start of the study, mean age was 5.2 yr, bone age was 4.0 yr, height SDS was -3.5, height velocity SDS was -0.8, weight SDS was -2.7, and body mass index SDS was -1.9. Catch-up growth was observed in none of the untreated and all of the treated children. The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS. GH treatment was associated with a distinct acceleration of bone maturation. The differences between the growth responses evoked by the two GH doses were minor. The prepubertal GH-induced catch-up growth was associated with elevated serum concentrations of insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and osteocalcin, whereas insulin-like growth factor-II levels remained unaltered. GH treatment was well tolerated. In conclusion, high-dose GH administration over 2 yr is emerging as a potential therapy to increase the short stature that results from insufficient catch-up growth in young children born small for gestational age. The long-term impact of this approach remains to be delineated.
Field Evaluation of a Rota- and Adenovirus Immunochromatographic Assay Using Stool Samples from Children with Acute Diarrhea in Ghana (2007)

We evaluated the Rida Quick rotavirus/adenovirus Combi rapid immunochromatographic test (ICT) under field conditions with Ghanaian children with acute diarrhea. Compared to PCR results, sensitivities and specificities were 75% and 95% for rotavirus and 22% and 84% for adenovirus. In resource-poor settings, ICTs may help to overcome difficulties in the diagnosis of rotavirus infection.
Short‐term field stimulation mimics synaptic maturation of hippocampal synapses (2012)

Many aspects of synaptic transmission are modified during development, reflecting not only the consequence of developmental programmes of gene expression, but also the effects of ongoing neural activity. We investigated the role of synaptic activity in the maturation of Schaffer collateral (SC)-CA1 synapses using sustained low frequency field stimulation of acute brain slices. Between postnatal days 4-6 and 14-16, mouse SC-CA1 synapses in naïve slices showed a developmental decrease in the probability of transmitter release (P(r)) and an increase in the contribution of GluN2A (NR2A) subunits to the NMDA receptor-mediated excitatory postsynaptic current (EPSC). Surprisingly, these developmental changes could be mimicked by short term (4 h) in vitro synaptic activity in slices taken from postnatal days (PND) 4-6 mice. However, different activity levels were required to alter release probability compared to the NMDA receptor subunit composition. Spontaneous synaptic activity was sufficient to alter the NMDA receptor subunit composition, but sustained low-frequency field stimulation of the brain slice (0.1 Hz, 4 h) was necessary to reduce release probability, as assessed 1 h following the cessation of stimulation. The protein synthesis inhibitor anisomycin blocked the effect of field stimulation on release probability. These results indicate that features of mature excitatory synapses can be rapidly induced in immature neurons. The activity dependence of the P(r) and NMDA receptor subunit composition serves as a sensitive indicator of prior neural activity, and provides dual mechanisms for homeostatic control of excitatory synaptic efficacy.
Early diagnosis of primary nonfunction and indication for reoperation after liver transplantation (2010)

Initial graft function is a major factor influencing the clinical outcome after liver transplantation (LTX), but a reliable method for assessing and predicting graft dysfunction directly after LTX is not available. Ninety-nine patients undergoing deceased-donor LTX were studied in a prospective pilot study to evaluate the LiMAx test, the indocyanine green test, and conventional biochemical parameters with respect to their sensitivity and prognostic power for the diagnosis of initial graft dysfunction. Patients suffering from initial graft dysfunction (defined as technical complications or primary nonfunction (n = 8)) had significantly decreased LiMAx readouts (43 +/- 18 versus 184 +/- 98 mug/kg/hour, P < 0.001) immediately after LTX. Univariate analysis also showed significant differences for serum bilirubin, ammonia, glutamate dehydrogenase, and the international normalized ratio (P < 0.05), but multivariate analysis revealed LiMAx as the single independent predictor of initial dysfunction (P = 0.008) with an area under the receiver operating characteristic curve (AUROC) of 0.960 (95% confidence interval = 0.921-0.998, P < 0.001). In addition, the diagnosis of primary nonfunction (n = 3) was evaluated with LiMAx and aspartate aminotransferase (AST) activity on the first postoperative day. The calculated AUROC values were 0.992 (0.975-1.0, P = 0.004) for LiMAx and 0.967 (0.929-1.0, P = 0.006) for AST. By a combination of test results obtained directly after LTX and on the first day, LiMAx indicated primary nonfunction with a sensitivity of 1.0 (0.31-1.0) and a positive predictive value of 1.0 (0.31-1.0), whereas AST classification showed a sensitivity of 0.67 (0.13-0.98) and a positive predictive value of 0.29 (0.05-0.70). In conclusion, the assessment of initial graft function using the LiMAx test might be effective for identifying critical complications that could threaten graft survival within 24 hours after LTX.
Microfluidic-based solid phase extraction of cell free DNA (2018)

Cell-free DNA (cfDNA) is a liquid biopsy marker that can carry signatures (i.e., mutations) associated with certain pathological conditions. Therefore, the extraction of cfDNA from a variety of clinical samples can be an effective and minimally invasive source of markers for disease detection and subsequent management. In the oncological diseases, circulating tumor DNA (ctDNA), a cfDNA sub-class, can carry clinically actionable mutations and coupled with next generation sequencing or other mutation detection methods provide a venue for effective in vitro diagnostics. However, cfDNA mutational analyses require high quality inputs. This necessitates extraction platforms that provide high recovery over the entire ctDNA size range (50 → 150 bp) with minimal interferences (i.e., co-extraction of genomic DNA), and high reproducibility with a simple workflow. Herein, we present a novel microfluidic solid-phase extraction device (μSPE) consisting of a plastic chip that is activated with UV/O3 to generate surface-confined carboxylic acid functionalities for the μSPE of cfDNA. The μSPE uses an immobilization buffer (IB) consisting of polyethylene glycol and salts that induce cfDNA condensation onto the activated plastic microfluidic surface. The μSPE consists of an array of micropillars to increase extraction bed load (scalable to loads >700 ng of cfDNA) and can be produced at low-cost using replication-based techniques. The entire μSPE can be fabricated in a single molding step negating the need for adding additional extraction supports to the device simplifying production and keeping device and assay cost low. The μSPE allowed for recoveries >90% of model cfDNA fragments across a range of sizes (100-700 bp) and even the ability to extract efficiently short cfDNA fragments (50 bp, >70%). In addition, the composition of the IB allowed for reducing the interference of co-extracted genomic DNA. We demonstrated the clinical utility of the μSPE by quantifying the levels of cfDNA in healthy donors and patients with non-small-cell lung and colorectal cancers. μSPE extracted cfDNA from plasma samples was also subjected to a ligase detection reaction (LDR) for determining the presence of mutations in the KRAS gene for colorectal and non-small cell lung cancer patients.
Mini-symposium on automatic differentiation and its applications in the financial industry (2017)

Automatic differentiation has been involved for long in applied mathematics as an alternative to finite difference to improve the accuracy of numerical computation of derivatives. Each time a numerical minimization is involved, automatic differentiation can be used. In between formal derivation and standard numerical schemes, this approach is based on software solutions applying mechanically the chain rule formula to obtain an exact value for the desired derivative. It has a cost in memory and cpu consumption.
Laser cladding using a high average-power Nd:YAG laser and optical fibres (1995)

We report a new laser cladding technique for producing wear and corrosion resistant surfaces on engineering components using a high average-power Nd:YAG laser and optical fibres. The technique involves injecting wear or corrosion resistant alloy powders through a nozzle into the laser beam on the surface of a substrate which is manipulated under the laser beam by a CNC system. The results using a nickel based alloy (Hastelloy C) indicate that uniform clad layers in excess of 1 mm in thickness can be achieved in a single pass with an incident average laser power of 240 W delivered through a step index glass fibre of length 5 m and core diameter 600 μm. The clad layer obtained is homogeneous, without porosity or cracks, and has very low dilution (less than 2%) by the substrate, to which it adheres firmly. These results, combined with a relatively high powder utilisation efficiency (about 60% when cladding a flat plate) and coverage rate (8 mm2s-1), make the technique particularly attractive for cladding thin substrates and engineering components that require both corrosion or wear resistant surfaces and high dimensional stability. In addition, the use of fibre optics to deliver the laser beam to the workpiece offers great opportunities for surfacing components remote from the laser source.
Delivery of Didanosine from Enteric-Coated, Sustained-Release Bioadhesive Formulation (2003)

The aim of our study is to assess the release characteristics, in vitro permeation, and stability of an enteric-coated, bioadhesive, sustained-release formulation of didanosine (ddI). Enteric-coated tablets of ddI, containing Polyox WSRN-303 and Methocel K4M, were prepared using hydroxypropylmethylcellulose phthalate (HPMCP 5.5). The enteric-coated formulation was resistant to dissolution in 0.1 N HCl solution but dissolved within 10 min (+/-2 min) in pH 7.4 phosphate buffered saline. The release profiles were linear with square root time. Stability studies indicate that the formulations were stable at 4 degrees C, room temperature, and 40 degrees C upon storage for 6 months. Polyox WSRN-303 tablets exhibited a higher ddI permeation ratio across live intestinal tissue compared with conventional tablets. Enteric-coated, sustained-release, bioadhesive tablets deliver ddI in small doses and at the same time prevent acid-induced degradation and hence hold a potential to improve ddI's oral bioavailability.
ChemInform Abstract: Versatile and Stereoselective Synthesis of Diamino Diol Dipeptide Isosteres, Core Units of Pseudopeptide HIV Protease Inhibitors. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A method for sectioning and handling frozen sections for scanning electron microscopy (1986)

Abstract Glutaraldehyde‐fixed insects were embedded in Tissue‐Tek R and sectioned on a liquid‐nitrogen‐cooled stage. The sections were sandwiched between two layers of microscope lens paper and all postsectioning treatments were carried out on this sandwich, including dehydration and critical‐point drying. In some cases, the sections were placed on filter membranes and lyophilized. These procedures produced intact specimens which maintained internal morphology as well as inter‐ and intracellular integrity without expensive or specialized equipment.
Synthesis, Structures, and Olefin Polymerization Capability of Vanadium(4+) Imido Compounds with <i>f</i><i>ac</i>-N<sub>3</sub> Donor Ligands (2006)

One-pot reactions of V(NMe2)4 with a range of primary alkyl- and arylamines RNH2 and Me3SiCl afforded the corresponding five-coordinate vanadium(4+) imido compounds V(NR)Cl2(NHMe2)2 [R = 2,6-C6H3(i)Pr2 (1a, previously reported), 2-C6H4(t)Bu (1b), 2-C6H4CF3 (1c), (t)Bu (1d), Ad (Ad = adamantyl, 1e)]. The crystal structures of 1b (two diamorphic forms) and 1c featured N-H...Cl hydrogen-bonded chains. Reaction of 1a-e with the neutral face-capping, N3 donor ligands TACN (TACN = 1,4,7-trimethyltriazacyclononane) or TPM [TPM = tris(3,5-dimethylpyrazolyl)methane] gave the corresponding six-coordinate complexes V(NR)(TACN)Cl2 (2a-e) and V(NR)(TPM)Cl2 (3a-e). The X-ray structures of 2b, 2c, 2d, 3b, 3c, and 3e were determined. When activated with methylaluminoxane, certain of the complexes V(NR)(TPM)Cl2 (3) formed moderately active ethylene polymerization catalysts, whereas none of the compounds V(NR)(TACN)Cl2 (2) were active.