gebhart/patrepeval huggingface dataset:
Withdrawal: Cytosolic proteins regulate α-synuclein dissociation from presynaptic membranes. (2020)

Cytosolic Proteins Regulate α-Synuclein Dissociation from Presynaptic MembranesJournal of Biological ChemistryVol. 281Issue 43PreviewIntracellular accumulation of insoluble α-synuclein in Lewy bodies is a key neuropathological trait of Parkinson disease (PD). Neither the normal function of α-synuclein nor the biochemical mechanisms that cause its deposition are understood, although both are likely influenced by the interaction of α-synuclein with vesicular membranes, either for a physiological role in vesicular trafficking or as a pathological seeding mechanism that exacerbates the propensity of α-synuclein to self-assemble into fibrils. Full-Text PDF Open Access VOLUME 281 (2006) PAGES 32148–32155 This article has been withdrawn by Sabine Wislet-Gendebien, Cheryl D'Souza, Toshitaka Kawarai, Peter St George-Hyslop, David Westaway, Paul Fraser, and Anurag Tandon. The α-synuclein and GAPDH bands at 30 min were superimposed on the earlier time points in Fig. 1B. The GAPDH bands in Fig. 4B were reused in Fig. 7A.
Solar electricity: Realizing the dream through digital inkjet metallization of multi-crystalline Si solar cell (2012)

Solar electricity is an attractive resource that can be tapped without exhaustion. However, solar cell, the device which converts sunlight into electricity must be cost effective to encourage widespread use of solar electricity. Cost-effective solar cell can be achieved through material usage, efficiency and economy of scale. The economy of scale has been employed since 2004 with production capacities in the 1 GW range for several companies, but the efficiency is not high enough because of the limitations in the current metallization technology. The alternative technologies, such as laser opening and plate, extrusion, laser transfer process, inkjet and aerosol seed and plate investigated by several researchers are still far away from production ready. The inkjet metallization is an alternative that is very promising because of the associated precision in material usage in creating fine and uniform gridlines for reduced shading. Efficiencies of >19% and 17.4%, respectively, on mono and multi-crystalline cells, have been demonstrated using the same process as with the screen-printing technology. In this paper the results of digital inkjet metallization of multi-crystalline silicon solar cell is presented, for the first time, with efficiency of 17.4%. The technology road map to achieve lower-cost and higher efficiency multi-crystalline solar cells is also presented.
1-Jahres-Ergebnisse funktionierender Sickerkissen in der OCT-Darstellung (2004)

Hintergrund: Evaluation der Darstellung von langfristig wirksamen, funktionierenden Sickerkissen in der Optischen Kohärenztomographie (OCT) in ihrem postoperativen Verlauf über ein Jahr.
GenderMag experiences in the field: The whole, the parts, and the workload (2016)

Recent research has reported numerous studies bringing into question the gender inclusiveness of many kinds of software. Inclusiveness of software (gender or otherwise) matters because supporting diversity matters - it is well-known that the more diverse a group of problem-solvers, the higher the quality of the solution. To help software creators identify features within their software that are not gender-inclusive, we recently created a method known as GenderMag. In this paper, we investigate the experience of teams of software professionals using GenderMag to find problems with software they are building. Our results show a high engagement with GenderMag personas - more than twice that of other personas research - and a very high degree of accuracy (93%) most of the time. Finally, our results pinpointed situations that we term “detours” that were especially prone to errors, with teams 6 times more likely to make errors in detours than they did otherwise.
Data association using empty convex polygonal regions in EKF-SLAM (2010)

This paper proposes a new framework for data association to solve the problem of SLAM. The proposed framework has specific relevance to range scanner based EKF-SLAM. The resulting data representation enables semantic reasoning on a spatial level which reduces the misassociation of closely spaced data from different spatial configurations through the use of convex polygons to represent data from similar spatial configurations. The data representation is especially effective for association when revisiting previously mapped regions efficiently. The spatial data representation also builds an occupancy grid for the entire map. We also provide a means of clustering range scan data using an adaptive threshold to be able to divide data at various ranges into clusters and dense data clustering to get more accurate data.
Lagrangian Simulation of Combustion (2008)

A Lagrangian approach for the simulation of reactive flows has been developed during the course of this project, and has been applied to a number of significant and challenging problems including the transverse jet simulations. An efficient strategy for parallel domain decomposition has also been developed to enable the implementation of the approach on massively parallel architecture. Since 2005, we focused our efforts on the development of a semi-Lagrangian treatment of diffusion, and fast and accurate Lagrangian simulation tools for multiphysics problems including combustion.
Primary ciliary dyskinesia: improving the diagnostic approach (2009)

The incorporation of nasal nitric oxide measurement as a screening test to define probable PCD cases and gene mutation analysis to make a definitive diagnosis of PCD should enhance diagnostic evaluation of PCD.
Test generation for multiple state-table faults in finite-state machines (2002)

A test generation procedure to detect multiple state-table faults in finite-state machines is proposed. The importance of multiple state-table faults and their advantages as test generation objectives to avoid the need for checking experiments are considered. The proposed procedure is based on a new method for implicit enumeration of large numbers of multiple faults by using incompletely specified faulty machines. Experimental results are presented to demonstrate the effectiveness of implicit fault enumeration in detecting large numbers of multiple faults.
Acoustoelastic Lamb wave propagation in biaxially stressed plates (2012)

Acoustoelasticity, or the change in elastic wave speeds with stress, is a well-studied phenomenon for bulk waves. The effect of stress on Lamb waves is not as well understood, although it is clear that anisotropic stresses will produce anisotropy in the Lamb wave dispersion curves. Here the theory of acoustoelastic Lamb wave propagation is developed for isotropic media subjected to a biaxial, homogeneous stress field. It is shown that, as expected, dispersion curves change anisotropically for most stresses, modes, and frequencies. Interestingly, for some mode-frequency combinations, changes in phase velocity are isotropic even for a biaxial stress field. Theoretical predictions are compared to experimental results for several Lamb wave modes and frequencies for uniaxial loads applied to an aluminum plate, and the agreement is reasonably good.
Autoantibodies to a transfer RNA-associated protein in a murine model of chronic graft versus host disease. (1994)

We established chronic graft vs host disease (GVHD) in (C57BL/10 x DBA/2)F1 mice with an injection of lymphoid cells from the parental DBA/2 strain. In addition to Abs earlier reported, of the 20 animals studied 13 developed Abs against transfer RNA/protein particles. Ten of the 13 sera immunoprecipitated a similar-sized RNA that co-migrated in PAGE with isoleucine tRNA. In immunoblots against proteins affinity purified using anti-isoleucyl-tRNA synthetase prototype serum, 7 of the 10 sera reacted with a polypeptide of 76 kDa that was similar in size to a protein recognized by a human anti-isoleucyl-tRNA synthetase serum. Three of 10 sera significantly and specifically inhibited isoleucyl-tRNA synthetase enzyme activity and one inhibited lysyl-tRNA synthetase activity. These data suggest that the autoantibodies to tRNA-associated proteins that develop in GVHD mice may react with amino acyl-tRNA synthetases, particularly those belonging to the multienzyme complex. Such autoantibodies are associated with myositis in humans, and these mice showed evidence compatible with myositis that appeared to be a manifestation of their GVHD. No previous example of spontaneous development of antisynthetases in animals has been described. We also demonstrated the presence of Abs against the NOR:90 nucleolar Ag as a new target in chronic GVHD. We conclude that chronic GVHD in mice provides a model for the study of the autoimmune responses that characterize human diseases such as mixed connective tissue disease, scleroderma, SLE, and myositis with a wider autoantibody response than that described so far.
Considerations on the Effects of their Particle Size and Shape on the Colour of Ferric Oxide Powders (1958)

In the previous paper of the author, the effects of particle size and shape on the colour of Fe2O3 powders were studied experimentally.
Healon5 tamponade of corneal perforation during transplantation surgery (2002)

In "a chaud" keratoplasty in cases of corneal perforation, the main difficulty is the trephination of the recipient cornea in a soft eye. A temporary tamponade of the perforation can be provided by filling the anterior chamber with sodium hyaluronate 2.3% (Healon5). The cornea can then be grasped with vacuum and trephinated.
The Relationship of Surface Science and Adhesion Science (2012)

No AccessAdhesion and Adhesives TechnologyJun 2012The Relationship of Surface Science and Adhesion ScienceAlphonsus V. PociusAlphonsus V. Pociushttps://doi.org/10.3139/9783446431775.006SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2012Pages: 145-179Print ISBN: 978-3-446-42748-8eISBN: 978-3-446-43177-5 Copyright & Permissions© 2012 Carl Hanser Verlag GmbH & Co. KGPDF DownloadLoading ...
Water Permeability of the Skin of the Amphibious Snake, Agkistrodon piscivorus (1985)

The cottonmouth (A. piscivorus) is a semi-aquatic fresh water snake which is closely related to the terrestrial copperhead (A. contortrix). Despite the differences in habitat preference, both species have similarly low integumentary water permeability in the summer. Influx and efflux of water measured between tritiated distilled water and a 1 M NaCl solution were about 20-50 gtmoles/cm2 h. These are fairly typical values for terrestrial snakes, but abnormally low for fresh water species. A. piscivorus were caught soon after emergence from hibernation, and successive shed skins tested under constant conditions over a five month period showed significant declines in water permeability with a minimum of about 20 pmoles/cm2-h in June-September. Newborn A. piscivorus placed in water for three weeks had significantly lower cutaneous water permeabilities than those dehydrated by about 27% of their initial body mass in air. Thus integumentary perme- ability may vary in response to the state of body fluid hydration. Skin water permeability appears to be controlled by lipids since their extraction causes an enormous increase in influx and efflux. The lipid extracted shed skin of A. piscivorus demonstrated a marked asymmetry in downhill water diffusion, with influx exceeding efflux.
Use of an active microelectrode array for stimulation and recording in the central nervous system (2003)

An advanced tool for performing rapid accurate stimulation and recording studies in the central nervous system (CNS) has been successfully demonstrated. An all-silicon 64-site, 4-channel microelectrode array (active probe) with the capability of multipolar stimulation fields as well as multipoint recording has been tested in-vivo. The capabilities of this neural probe make it a powerful tool for studying the CNS and in realizing a neuroprosthesis.
Experimental measurement of photoresist modulation curves (2006)

An approach to measurement of resist CD response to image modulation and dose is presented. An empirical model with just three terms is used to describe this response, allowing for direct calculation of photoresist modulation curves. A thresholded latent image response model has been tested to describe CD response for both 90 nm and 45 nm geometry. An assumption of a linear optical image to photoresist latent image correlation is shown as adequate for the 90 nm case, while the 45 nm case demonstrates significant non-linear behavior. This failure indicates the inadequacy of a "resist blur" as a complete descriptive function and uncovers the need for an additional spread function in OPE-style resist models.
A Pictish symbol stone from Golspie, Sutherland (1943)

A flat slab lying on top of a short cist was found to be carved. it was not the original capstone. On one face are incised five symbols lightly scribed, the markings\r\nbeing not more than mere scorings, which might have been engraved by the rounded point of a small nail. At the top of the stone is a crescent symbol with downward horns. The central portion has a geometrical design of curved lines, which is balanced on each side by another pattern of spirals. There is also a v-rod, a crescent, an elephant, a mirror and a comb.
Prothero, Mr. George Walter and Mrs. Margaret "Fanny", [1906-1913] [October?] [n.d.] (1906)

Lamb House, no date, Thursday 3.15.; includes undated envelope; redated from [n.y.] 7/30/10 RDS
Inversion and Eversion Strengths in the Weightbearing Ankle of Young Women (2001)

Maximum isometric ankle inversion and eversion muscle strengths were measured under full unipedal weightbearing in 20 healthy young adult women. When the women wore a low-top shoe, the mean (standard deviation) maximum external eversion moments resisted with the foot in 0 degrees and 32 degrees of ankle plantar flexion were 24.1 (7.6) and 24.1 (8.1) N x m, respectively, while the corresponding values for maximum inversion moments resisted were 14.7 (6.8) and 17.4 (6.4) N x m, respectively. Both shoe height and ankle plantar flexion affected the overall inversion moment resisted by 17% (P = 0.03) at 0 degrees of ankle plantar flexion to 11.9% (P = 0.003) at 32 degrees of ankle plantar flexion. However, neither shoe height nor ankle plantar flexion significantly affected the maximum eversion moment resisted. Although eversion muscle strength of the young women averaged 39% less than the corresponding value found in young men, the sex difference was not significant when ankle strengths were normalized by body size (body weight x height). Thus, when data from healthy young men and women were averaged, eversion and inversion strengths averaged 1.6% and 2.7%, respectively, of body weight x height.
The role of α‐, 3<sub>10</sub>‐, and π‐helix in helix→coil transitions (2003)

The conformational equilibrium between 3(10)- and alpha-helical structure has been studied via high-resolution NMR spectroscopy by Millhauser and coworkers using the MW peptide Ac-AMAAKAWAAKA AAARA-NH2. Their 750-MHz nuclear Overhauser effect spectroscopy (NOESY) spectra were interpreted to reflect appreciable populations of 3(10)-helix throughout the peptide, with the greatest contribution at the N and C termini. The presence of simultaneous alphaN(i,i + 2) and alphaN(i,i + 4) NOE cross-peaks was proposed to represent conformational averaging between 3(10)- and alpha-helical structures. In this study, we describe 25-nsec molecular dynamics simulations of the MW peptide at 298 K, using both an 8 A and a 10 A force-shifted nonbonded cutoff. The ensemble averages of both simulations are in reasonable agreement with the experimental helical content from circular dichroism (CD), the (3)J(HNalpha) coupling constants, and the 57 observed NOEs. Analysis of the structures from both simulations revealed very little formation of contiguous i --> i + 3 hydrogen bonds (3(10)-helix); however, there was a large population of bifurcated i --> i + 3 and i --> i + 4 alpha-helical hydrogen bonds. In addition, both simulations contained considerable populations of pi-helix (i --> i + 5 hydrogen bonds). Individual turns formed over residues 1-9, which we predict contribute to the intensities of the experimentally observed alphaN(i,i + 2) NOEs. Here we show how sampling of both folded and unfolded structures can provide a structural framework for deconvolution of the conformational contributions to experimental ensemble averages.
AtALMT12 represents an R-type anion channel required for stomatal movement in Arabidopsis guard cells (2010)

Stomatal pores formed by a pair of guard cells in the leaf epidermis control gas exchange and transpirational water loss. Stomatal closure is mediated by the release of potassium and anions from guard cells. Anion efflux from guard cells involves slow (S-type) and rapid (R-type) anion channels. Recently the SLAC1 gene has been shown to encode the slow, voltage-independent anion channel component in guard cells. In contrast, the R-type channel still awaits identification. Here, we show that AtALMT12, a member of the aluminum activated malate transporter family in Arabidopsis, represents a guard cell R-type anion channel. AtALMT12 is highly expressed in guard cells and is targeted to the plasma membrane. Plants lacking AtALMT12 are impaired in dark- and CO2-induced stomatal closure, as well as in response to the drought-stress hormone abscisic acid. Patch-clamp studies on guard cell protoplasts isolated from atalmt12 mutants revealed reduced R-type currents compared with wild-type plants when malate is present in the bath media. Following expression of AtALMT12 in Xenopus oocytes, voltage-dependent anion currents reminiscent to R-type channels could be activated. In line with the features of the R-type channel, the activity of heterologously expressed AtALMT12 depends on extracellular malate. Thereby this key metabolite and osmolite of guard cells shifts the threshold for voltage activation of AtALMT12 towards more hyperpolarized potentials. R-Type channels, like voltage-dependent cation channels in nerve cells, are capable of transiently depolarizing guard cells, and thus could trigger membrane potential oscillations, action potentials and initiate long-term anion and K+ efflux via SLAC1 and GORK, respectively.
Inflammatory Aneurysms of the Ascending Aorta: Diagnosis and Surgical Treatment (2011)

Inflammatory aortic aneurysms (IAAs) are rare and located mainly in the infra-renal abdominal aorta. The ascending aorta has been typically spared from this process. We report on two cases of ascending aortic inflammatory aneurysms and describe the available literature on this rare entity.
Studies on pyrimidine derivatives. XXII. Site-selective oxidation of di-methylpyrimidines with selenium dioxide to pyrimidine-monoaldehydes. (1981)

The oxidation of 2, 4-dimethylquinoline and its 1-oxide with an equimolecular amount of selenium dioxide in boiling dioxane afforded 4-methylquinoline-2-carbaldehyde and its 1-oxide, respectively. This oxidation was applicable to the selective preparation of pyrimidine-4-carbaldehydes from dimethylpyrimidines. In case of pyrimidine derivatives, the presence of an N-oxide group facilitated the oxidation, but the isolated yields of the pyrimidinecarbaldehyde N-oxides were unsatisfactory, because of their instability.
MASTER KEY project: A basket/umbrella trial for rare cancers in Japan (2018)

Background: Rare cancers have had a challenge in establishing standard therapies for patients compared to major cancers, due to the lack of basis for clinical studies and investigations. We started a biomarker driven basket/umbrella trial using a “master protocol”, called the MASTER KEY Project, which aims to find more efficient ways to evaluate treatments for rare cancers and to build a treatment development infrastructure by collaborating with industries. Similar studies including NCI-MATCH trial are ongoing; however, MASTER KEY Project is the first to be reported for such large scale trials that focuses only on rare cancers. Trial design: The project consists of two main parts: the prospective registry study part and the multiple clinical trials (sub-study) part. Patients with advanced rare cancers (annual incidence less than 6 cases per 100,000 population)/cancers of unknown primary/rare pathological subtypes of major cancers, who have priorly been evaluated by a molecular diagnostic testing, such as a validated next generation sequencing assay, are enrolled into the registry study. The primary objective of the registry study is to collect consecutive data on biomarker, patient background, and prognosis to build a large-scale database highly reliable for use as historical control data in future clinical trials. In the sub-studies, drugs are provided by various industries, who are collaborators. Sub-studies are placed under a “master protocol”, allowing new sub-studies to be added at any time. Each sub-study is ordinarily a single arm study and will enroll 5-20 patients with the appropriate biomarker of interest, regardless of histopathologic tumor type. A biomarker-negative sub-study will also be available so that all patients have a chance to be enrolled in a sub-study. The project opened in May 2017. As of April 2018, more than 200 of a planned 100 patients/year have been enrolled in the project. There are three ongoing sub-studies. Two of them are biomarker related studies, which enroll patients harboring BRAF mutation and mismatch repair deficiency, respectively. In addition, three sub-studies are under planning and they will open by fall of 2018. Clinical trial identification: UMIN000027552. Legal entity responsible for the study: National Cancer Center Hospital. Funding: Eisai Co., Ltd., Daiichi Sankyo Co., Ltd., Astellas Pharma Inc., Ono Pharmaceutical Co., Ltd., Pfizer Japan Inc., Takeda Pharmaceutical Co., Ltd., Bristol-Myers Squibb Co., Ltd., Taiho Pharmaceutical Co., Ltd., Chugai Pharmaceutical Co., Ltd., Kyorin Pharmaceutical Co., Ltd. and Novartis Pharma Co.,Ltd., Japan Agency for Medical Research and Development. Disclosure: All authors have declared no conflicts of interest.
Accelerated mirror descent in continuous and discrete time (2015)

We study accelerated mirror descent dynamics in continuous and discrete time. Combining the original continuous-time motivation of mirror descent with a recent ODE interpretation of Nesterov's accelerated method, we propose a family of continuous-time descent dynamics for convex functions with Lipschitz gradients, such that the solution trajectories converge to the optimum at a O(1/t2) rate. We then show that a large family of first-order accelerated methods can be obtained as a discretization of the ODE, and these methods converge at a O(1/k2) rate. This connection between accelerated mirror descent and the ODE provides an intuitive approach to the design and analysis of accelerated first-order algorithms.
Microstructure and oxidation behavior at 1100ÃÂ°C of nickel-base alloys containing hafnium carbides (2016)

Three nickel-base alloys containing 25wt.%Cr, 0.25 to 0.50wt.%C andHf contents high enough to obtain significant hafnium carbides for achieving high strength at high temperature were elaborated by foundry then exposed at 1100°C for 46 hours. Afterwards they were observed in cross section and submitted to indentation tests. Interdendritic HfC carbides were successfully obtained, alone for given Hf/C atomic percent ratio or with additional Cr carbides. The HfC volume fractions slightly decreased during the 1100°C stage while, inversely, chromium carbides grew a little.The room temperature hardness was lowered of 25- 40Hv consecutively to the HfC fragmentation occurred during the 1100°C stage. The cross-sectional surface characterization showed that the three alloys well behaved in oxidation at 1100°C, with an external chromia scale and Cr content remained high in subsurface.