gebhart/patrepeval huggingface dataset:
SLSF project pretest analysis for experiment P-4 (1983)

By incorporating focused feedback from families and other stakeholders a multidisciplinary team redesigned a single nurse home visit to improve transitions to home for pediatric patients following short-stay, acute care hospitalizations. Refinements to the nurse-led transitional home visit included standardization of teaching focused on condition- and medication-specific concerns, the use of red flags or warning signs to prompt caregiver action, and the provision of reassurance.
Adaptive Envelope MDPs for Relational Equivalence-based Planning (2008)

We describe a method to use structured representations of the environmentâs dynamics to constrain and speed up the planning process. Given a problem domain described in a probabilistic logical description language, we develop an anytime technique that incrementally improves on an initial, partial policy. This partial solution is found by ï¬rst reducing the number of predicates needed to represent a relaxed version of the problem to a minimum, and then dynamically partitioning the action space into a set of equivalence classes with respect to this minimal representation. Our approach uses the envelope MDP framework, which creates a Markov decision process out of a subset of the full state space as de- termined by the initial partial solution. This strategy permits an agent to begin acting within a restricted part of the full state space and to expand its envelope judiciously as resources permit.
[Marfan's syndrome in Iceland.]. (1996)

Marfan's syndrome is a heritable collagen disorder manifested by defects in the ocular, skeletal and cardiovascular systems. It is inherited as an autosomal dominant trait. The objectives of this study were to study the prevalence and clinical presentation of Marfan's syndrome in Iceland. We assessed the records of patients diagnosed with Marfan's syndrome during the years 1989-94 at all the major hospitals in Iceland. Hospital cardiologists, pediatricians and ophthalmologists gave valuable information, as did some general practitioners. All patients who agreed to participate were evaluated by an ophthalmologic inspection and an echocardiogram was obtained. A family history was taken and a general physical examination was performed. Twenty two patients were evaluated, at the age seven to 71 years. Seventeen of them had a definitive diagnosis of Marfan's syndrome with a mean age of 27 years. Five patients did not meet the clinical criteria for Marfan's syndrome. Accordingly the prevalence of Marfan's syndrome in Iceland is 6.5/100.000. Ocular involvement was observed in 14 (82%) and 11 (65%) had a dislocated lens. Cardiovascular abnormalities were seen in 11 (65%) patients, nine (53%) had aortic root dilatation and six (35%) had mitral valve prolaps. All patients had skeletal abnormalities. They were tall, skinny, with long extremeties and arachnodactyly. Pectus carinatum was observed in seven (41%) patients. A family history was noted in 12 patients and five (29%) seem to be sporadic cases. Thus, Marfan's syndrome exists in Iceland and it's prevalence and clinical presentation seems to be in concordance with other published studies in the western world.
<i>S</i>-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut (2018)

Alcoholic beverages are enjoyed together with meals worldwide, but their excessive intake is associated with an increased risk of various diseases. We investigated whether S-allyl-L-cysteine sulfoxide (ACSO), a sulfuric odor precursor of garlic, suppresses elevation in plasma ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from the gut in rats. ACSO and garlic extract with a high ACSO content (Garlic-H) suppressed elevation in concentrations of ethanol and acetaldehyde in plasma and promoted the activities of alcohol dehydrogenase and aldehyde dehydrogenase. However, ACSO and Garlic-H did not affect plasma acetate so much. Furthermore, we examined the change in plasma ethanol concentration by injecting ACSO or Garlic-H into the ligated stomach or jejunum together with ethanol solution. ACSO and Garlic-H suppressed the absorption of ethanol from the stomach and jejunum, but suppression in the jejunum was less than in the stomach. In conclusion, ACSO inhibits ethanol absorption and accelerates ethanol metabolism.
Multiple Elements for Negative Regulation of the Rat Catalase Gene Expression in Dedifferentiated Hepatoma Cells (2000)

Like such hepatic genes as those for albumin and aldolase B, the rat catalase gene shows markedly reduced expression in carcinogenesis of hepatocytes. Strong silencer activity has been widely observed in the 5'-flanking region of the gene, downstream from the G-rich sequence identified in a previous study. In this study, we identified and characterized multiple elements involved in negative regulation of catalase gene expression by reporter assay and gel shift assay. One of the silencer elements is located 3 kb upstream of the gene and has GATATCCCGATATC as core sequence. The observation that protein binding to the element is abundantly expressed in dedifferentiated hepatoma cell lines, but scarcely in well-differentiated cell lines suggests that this element is involved in negative regulation of the catalase gene expression in hepatocarcinogenesis. This element was targeted by a novel 20-kDa nuclear protein, which is designated HNRF (hepatocarcinogenesis-related negative regulatory factor).
Anisotropy of electron mobility in arbitrarily oriented FinFETs (2007)

We simulated the behavior of electron mobility and the effect of volume inversion in FinFETs with different surface (hkl) orientations and channel <hkl> directions, using a Monte Carlo simulator. For each surface orientation, different channel directions were also considered. In the case of the (110) surface, a strong anisotropy of electron mobility with channel direction was seen: when the channel was in the (110)/<001> direction, electron mobility was 50% higher than in (110)/<1-10>, and was similar to the mobility for a (100)/<001> direction. This anisotropic behavior with channel orientation was not observed in the (100)-or (111)-surface orientations. The study with silicon thickness also revealed some interesting consequences of the volume inversion effect.
A storage model with random release rate for modeling exposure to food contaminants (2008)

This paper presents the study of a continuous-time piecewise-deterministic Markov process for describing the temporal evolution of exposure to a given food contaminant. The quantity X of food contaminant present in the body evolves through its accumulation after repeated dietary intakes on the one hand, and the pharmacokinetics behavior of the chemical on the other hand. In the dynamic modeling considered here, the accumulation phenomenon is modeled by a simple marked point process with positive i.i.d. marks, and elimination in between intakes occurs at a random linear rate OX, randomness of the coefficient B accounting for the variability of the elimination process due to metabolic factors. Via embedded chain analysis, ergodic properties of this extension of the standard compound Poisson dam with (deterministic) linear release rate are investigated, the latter being of crucial importance in describing the long-term behavior of the exposure process (X-t)(t >= 0) and assessing values such as the proportion of time the contaminant body burden is over a certain threshold. We also highlight the fact that the exposure process is generally not directly observable in practice and establish a validity framework for simulation-based statistical methods by coupling analysis. Eventually, applications to methyl mercury contamination data are considered.
O-Acylhydroxylamines. II. O-Mesitylenesulfonyl-, O-p-Toluenesulfonyl- and O-Mesitoylhydroxylamine<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTO-Acylhydroxylamines. II. O-Mesitylenesulfonyl-, O-p-Toluenesulfonyl- and O-Mesitoylhydroxylamine1Louis A. CarpinoCite this: J. Am. Chem. Soc. 1960, 82, 12, 3133–3135Publication Date (Print):June 1, 1960Publication History Published online1 May 2002Published inissue 1 June 1960https://pubs.acs.org/doi/10.1021/ja01497a037https://doi.org/10.1021/ja01497a037research-articleACS PublicationsRequest reuse permissionsArticle Views1626Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Signal Enhancement of Surface Enhanced Raman Scattering and Surface Enhanced Resonance Raman Scattering Using in Situ Colloidal Synthesis in Microfluidics (2010)

We demonstrate the enhanced analytical sensitivity of both surface enhanced Raman scattering (SERS) and surface enhanced resonance Raman scattering (SERRS) responses, resulting from the in situ synthesis of silver colloid in a microfluidic flow structure, where both mixing and optical interrogation were integrated on-chip. The chip-based sensor was characterized with a model Raman active label, rhodamine-6G (R6G), and had a limit of detection (LOD) of ca. 50 fM (equivalent to single molecule detection). The device was also used for the determination of the natural pigment, scytonemin, from cyanobacteria (as an analogue for extraterrestrial life existing in extreme environments). The observed LOD of approximately 10 pM (ca. <400 molecules) demonstrated the analytical advantages of working with freshly synthesized colloid in such a flow system. In both cases, sensitivities were between 1 and 2 orders of magnitude greater in the microfluidic system than those measured using the same experimental parameters, with colloid synthesized off-chip, under quiescent conditions.
Ventral Striatal D2/3 Receptor Availability Is Associated with Impulsive Choice Behavior As Well As Limbic Corticostriatal Connectivity (2018)

We conclude that delay-discounting task impulsivity is associated with low D2/3 receptor binding in the nucleus accumbens core. Thus, two related forms of waiting impulsivity-premature responding and delay intolerance in a delay-of-reward task-implicate an involvement of D2/3 receptor availability in the nucleus accumbens shell and core, respectively. This dissociation may be causal or consequential to enhanced functional connectivity of limbic brain circuitry and hold relevance for attention-deficit/hyperactivity disorder, drug addiction, and other psychiatric disorders.
Evaluating Devices for Treating Epilepsy (2003)

The proper evaluation, use, and acceptance of antiepileptic devices will ultimately depend on carefully executed clinical trials that take into account unique aspects of these devices, such as the requirement for surgery, electrode placement, and navigation through FDA-monitored testing and approval.
Torque and Bulk Flow of Ferrofluid in an Annular Gap Subjected to a Rotating Magnetic Field (2006)

We report analysis and measurements of the torque and flow of a ferrofluid in a cylindrical annulus subjected to a rotating magnetic field perpendicular to the cylinder axis. The presence of the inner cylinder results in a nonuniform magnetic field in the annulus. An asymptotic analysis of the ferrohydrodynamic torque and flow assuming linear magnetization and neglecting the effect of couple stresses indicated that the torque should have a linear dependence on field frequency and quadratic dependence on field amplitude. To the order of approximation of the analysis, no bulk flow is expected in the annular gap between stationary cylinders. Experiments measured the torque required to restrain a polycarbonate spindle surrounded by ferrofluid in a cylindrical container and subjected to the rotating magnetic field generated by a two-pole magnetic induction motor stator, as a function of the applied field amplitude and frequency, and for various values of the geometric aspect ratios of the problem. The ultrasound velocity profile method was used to measure the azimuthal and axial velocity profiles in the ferrofluid contained in the annular gap of the apparatus. Flow measurements show the existence of a bulk azimuthal ferrofluid flow between stationary coaxial cylinders with a negligible axial velocity component. The fluid was found to corotate with the applied magnetic field. Both the torque and flow measurements showed power-of-one dependence on frequency and amplitude of the applied magnetic field. This analysis and these experiments indicate that the action of antisymmetric stresses is responsible for the torque measured on the inner cylinder, whereas the effect of body couples is likely responsible for bulk motion of the ferrofluid.
[Clinical study of RU 23908 (nilutamide) in prostatic cancer]. (1991)

To investigate the efficacy and the safety of RU23908 for the treatment of prostatic cancer, an early phase 2 study with the oral administration of 150 or 300 mg daily was performed in 47 patients with stage C or D prostatic cancer at 15 institutions from April 1987 to June 1988. Forty patients were evaluable for efficacy. Concerning the effect on the object lesion, the results of the overall evaluation revealed that complete or partial response (CR + PR) was obtained in 34 of the 40 cases (85.0%). As to the effect classified by site, CR + PR were observed in 35 out of the 40 cases with primary lesion (87.5%), in 10 of the 22 cases with bone metastasis (45.5%), in 5 of the 6 cases with lymph node metastasis (83.3%) and CR was observed in one case with lung metastasis. In the PAP evaluation, 33 out of the 34 cases were judged to be CR + PR (97.1%). The improvement rate of clinical symptoms was 88.9% for bone pain, 83.3% for dysuria and 45.5% for performance status. Adverse reactions were observed in 29 of the 47 cases (61.7%) investigated and 7 cases (14.9%) were withdrawn. During the study period of 12 weeks and the subsequent period of continued administration, 6 cases (12.8%) and 2 possible cases of interstitial pneumonia were diagnosed. From the above results, the treatment of prostatic cancer with RU23908 150 mg/day or 300 mg/day in combination with surgical castration showed an excellent clinical effect compared to conventional endocrine therapy, but has a problem of safety. Therefore, this drug may be expected to be a highly useful therapeutic drug, if safely is improved in the future by reviewing the dose.
Mössbauer study of permanent-magnet R2Fe17−<i>x</i>M<i>x</i>C<i>y</i> compounds (1996)

We report Fe57 Mössbauer spectroscopy studies of the effect of carbon doping on the magnetic properties of the Fe sites of R2Fe17−xMxCy, and of the presence of multiple phases in these systems. In this study two systems, Sm2Fe14Al3Cy, where y=0, 1.0, 2.0, and 3.0, and Nd2Fe14.54Si2.46Cy, where y=0, 0.432, and 2.544, were measured at room temperature and analyzed. The ternary compounds R2Fe17−xMxCy studied here have the rhombohedral Th2Zn17 structure with c-axis anisotropy. The Al and Si site occupation used in the fitting were taken from previous results. Analysis of the Mössbauer spectra showed that the hyperfine fields for the different sites decreased in the order 6c, 9d, 18f, and 18h. The average hyperfine field for Sm2Fe14Al3Cy was found to increase with increasing carbon concentration, which is in qualitative agreement with magnetic measurements. For Nd2Fe14.54Si2.46Cy the average hyperfine field was found to increase for low C concentration and decrease for high C concentration; this behavior is in agreement with our magnetization measurements. The measured average isomer shift relative to α-iron was found to increase with y. In these compounds alloying with C and/or M can improve the magnetic properties such as Curie temperature and magnetization which make them potential candidates for permanent magnet development.
Characterization of a range of alkyl‐bonded silica HPLC stationary phases: XPS and ToF‐SIMS studies (1994)

Abstract A series of alkyl‐bonded silica HPLC stationary phases with a mean particle diameter of 5 μm has been prepared using a variety of dimethylalkylsilyl chlorides (i.e. monofunctional bonding agents) with alkyl chain lengths varying from C1 to C18, including phenyl and cyanopropyl groups. The stationary phases have been characterized using XPS and time‐of‐flight (ToF)‐SIMS. Elemental analyses by XPS have identified trace quantities of iron, sodium and chlorine at the silica/dimethylalkylsilyl chain interface, and aluminium was detected by ToF‐SIMS. A comparison of percentage carbon obtained by XPS with bulk carbon‐loading analyses suggests that the alkyl chains are bonded to the surface of the porous silica particles. Molecular ions characteristic of the dimethylalkylsilyl groups were identified in the ToF‐SIMS data together with ions attributable to these alkylsilyl groups attached to fragments of silica, the latter indicating covalent bonding to the silica surface. In addition, a series of low‐mass signals corresponding to alkyl chain fragments and silyl/silica‐based ions was observed. The value of high‐resolution ToF‐SIMS data for ion assignments is well demonstrated. The relative ion intensities of several of these low‐mass ions were studied as a function of changing alkyl chain length. In general, as the alkyl chain length increased, the abundance of the silicon‐containing fragments decreased, whilst the abundance of the alkyl‐based fragments increased, within the ToF‐SIMS spectra.
The relevance of f/sub T/ and f/sub max/ for the speed of a bipolar CE amplifier stage (1997)

Expressions relating the bandwidth of a common-emitter (CE) amplifier stage and the small-signal CML gate delay time to directly measurable transistor parameters, such as f/sub T/, f/sub max/, and input bandwidth f/sub /spl upsi//, are presented. They are valid for an arbitrary division of the base resistance and base-collector depletion capacitance into internal and external components. No resistance measurements are needed. It is shown that the transistor input bandwidth f/sub /spl upsi// is an important figure of merit for the speed of a CE stage. Under a given bias condition, f/sub /spl upsi// is determined by the base resistance and the cut-off frequency. In most cases the value of the maximum oscillation frequency f/sub max/ is only of minor importance. It would therefore be more meaningful to present besides f/sub T/ also f/sub /spl upsi// instead of f/sub max/ as a figure of merit for transistors for high-speed, low-power analog and digital circuits.
Parasite Chemotherapy (1962)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Synthesis and Luminescence Properties of (N-Doped) ZnO Nanostructures from a Dimethylformamide Aqueous Solution (2009)

The paper reports on the optical properties of ZnO nanostructures elaborated on a zinc foil substrate by a simple chemical approach. The doping type and density of the ZnO nanostructures were evaluated using electrochemical impedance spectroscopy. XRD diffraction patterns and Raman spectroscopy were used to study the structural properties evolution upon thermal annealing at 300 °C for 1 h in air. Their optical properties, probed by low temperature photoluminescence and room temperature cathodoluminescence (CL), are correlated to their electronic and structural properties. The luminescence of the nanorods is dominated by a broad near band edge emission located in the blue-violet region of the optical spectrum. Analysis of the CL spectra and monochromatic CL images show that the main luminescence has an extrinsic origin, which is tentatively assigned to nitrogen impurities.
CoSMoS: a visual environment for component-based modeling, experimental design, and simulation (2009)

An integrated modeling and simulation tool called Component-based System Modeler and Simulator (CoSMoS) is developed. It supports visual development of families of models that have well-defined logical specifications. The logical component-based models persist in relational databases and may be auto
On the kinetics and mechanism of thermal degradation of polystyrene, 2. Formation of volatile compounds (1984)

Abstract Thermal degradation of polystyrene (PS) was carried out in the absence of oxygen between 292 and 336°C. The formed volatile products were analysed qualitatively and quantitatively by means of gas charomatography. It was found that the composition of the volatile fraction is a function of conversion and independent of temperature for most of the products. A radical chain mechanism is proposed to explain these experimental results.
An in vitro test of the efficacy of an anti-biofilm wound dressing. (2014)

Broad-spectrum antimicrobial agents, such as silver, are increasingly being formulated into medicated wound dressings in order to control colonization of wounds by opportunistic pathogens. Medicated wound dressings have been shown in-vitro to be effective against planktonic cultures, but in-vivo bacteria are likely to be present in biofilms, which makes their control and eradication more challenging. Recently, a functional wound dressing (AQUACEL(®) Ag+ Extra™ (AAg + E)) has been developed that in addition to silver contains two agents (ethylenediaminetetraacetic acid (EDTA) and benzethonium chloride (BC)) designed to disrupt biofilms. Here, the efficacy of AAg + E is demonstrated using a biofilm model developed in an isothermal microcalorimeter. The biofilm was seen to remain viable in the presence of unmedicated dressing, silver-containing dressing or silver nitrate solution. In the presence of AAg + E, however, the biofilm was eradicated. Control experiments showed that neither EDTA nor BC alone had a bactericidal effect, which means it is the synergistic action of EDTA and BC disrupting the biofilm with silver being bactericidal that leads to the product's efficacy.
Compiled multithreaded data paths on FPGAs for dynamic workloads (2013)

Hardware supported multithreading can mask memory latency by switching the execution to ready threads, which is particularly effective on irregular applications. FPGAs provide an opportunity to have multithreaded data paths customized to each individual application. In this paper we describe the compiler generation of these hardware structures from a C subset targeting a Convey HC-2ex machine. We describe how this compilation approach differs from other C to HDL compilers. We use the compiler to generate a multithreaded sparse matrix vector multiplication kernel and compare its performance to existing FPGA, and highly optimized software implementations.
SliceMap: an algorithm for automated brain region annotation (2017)

Supplementary data are available at Bioinformatics online.