gebhart/patrepeval huggingface dataset:
Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients. (2001)

PTEN/MMAC1 is a putative tumor suppressor gene located on 10q23, one of the most frequently deleted chromosomal regions in human prostate cancer. Although mutations of PTEN have often been detected in metastases of prostate cancer, localized tumors have shown lower rates of mutation, which have varied from 0 to 20% among different studies. It is unknown whether the rate of PTEN mutations is different in prostate cancer from Asian men compared with Western men. To further clarify the role of PTEN in prostate cancer and to examine the gene for mutations in Asian men, we analyzed 32 cases of primary prostate cancers from Chinese patients, each of whom was not diagnosed by screening with serum prostate-specific antigen, for PTEN mutations using the methods of tissue microdissection, single-strand conformational polymorphism, and direct DNA sequencing. Seventy % of the tumors were Gleason scores 8-10, whereas the remainder were Gleason score 7. Six metastases of prostate cancer from American patients were also analyzed. Five of 32 (16%) primary prostate cancers from Chinese men and two of six metastases from American men showed mutations in a total of 10 codons of PTEN, which involved exons 1, 2, 5, 8, and 9. Two of the mutations were truncation type, whereas the rest were missense mutations. The mutation frequency in these cases from Asian patients was higher than that in our previous study of cases in radical prostatectomy specimens from American men, in which the 40 primary tumors were lower grade and had been detected by serum prostate-specific antigen test. We conclude that mutation of PTEN occurs more often in primary prostate cancers of Chinese men, whose tumors are high grade and reflective of an unscreened population.
CeO2 박막의 특성 향상을 위한 열처리 기술 (2003)

The CeO2 films were formed on Si(111) substrate by rf-magnetron sputtering. The hysteresis was observed from the capacitance-voltage(C-V) characteristics of the sample. However, after the CeO2-Si structure was annealed under O2 ambient, the hysteresis almost disappeared due to the SiO2 layer formed between CeO2 and Si. The annealed film showed the higher capacitance at accumulation due to the large dielectric constant, and the higher breakdown voltage due to the thin SiO2 layer. It was found that Poole-Frenkel emission (1-2MV/cm) and Schottky emission (<1MV/cm) were the conduction mechanisms for the annealed film. This CeO2/SiO2/Si structure was shown to be a candidate for FRAM device applications.
Fabrication of Reaction Sintered SiC Materials by Complex Slurry with Nano Size Particles (2005)

The efficiency of complex slurry preparation route for developing the high performance SiC matrix of RS-SiCf/SiC composites has been investigated. The green bodies for RS-SiC materials prior to the infiltration of molten silicon were prepared with various C/SiC complex slurries, which associated with both the sizes of starting SiC particles and the blending conditions of starting SiC and C particles. The characterization of RS-SiC materials was examined by means of SEM, EDS and three point bending test. Based on the mechanical property-microstructure correlation, the process optimization is also discussed. The flexural strength of RS-SiC materials greatly depended on the content of residual Si The decrease of starting SiC particle size in the C/SiC complex slurry was effective for improving the flexural strenth of RS-SiC materials.
Efficacy of Sweeteners and Sugar Substitutes in Caries Prevention (1993)

The caries-preventive efficacy of sweeteners and sugar substitutes is not clearly established on an epidemiological scale. A review of cariogenicity assessments in vitro and in vivo as well as of human clinical caries trials, however, clearly demonstrates that the replacement of sugar by such products has a caries-preventive effect. The clinical relevance of some bacteriostatic and/or cariostatic properties ascribed to saccharin, aspartame, and xylitol remains to be corroborated.
The responsibility management system for collaborative meeting scheduling in the Distributed System Engineering project (2003)

This paper presents a role-based cooperative session scheduling system and its application to the cooperation scenario of the DSE project for design review activities in the space domain. Our approach allows generic group definition. In contrast to identity-based group definition we use a role-based approach, allowing exceptions due to changes of identities and locations to be handled. Our solution relies on open generic groups and has two advantages. On one hand, it allows dynamic sessions to be managed, allowing evolution of the supported activities. On the other, it allows an invitation mechanism to be implemented as in traditional planning-based session management systems.
Relationship of the Acoustic Startle Response and Its Modulation to Adaptive and Maladaptive Behaviors in Typically Developing Children and Those With Autism Spectrum Disorders: A Pilot Study (2019)

<b>Background</b>: Autism spectrum disorder (ASD) is associated with persistent impairments in adaptive functioning across multiple domains of daily life. Thus, investigation of the biological background of both adaptive and maladaptive behaviors may shed light on developing effective interventions for improving social adaptation in ASD. In this study, we examined the relationship between adaptive/maladaptive behaviors and the acoustic startle response (ASR) and its modulation, which are promising neurophysiological markers for ASD translational research. <b>Method</b>: We investigated the ASR and its modulation in 11 children with ASD and 18 with typical development (TD), analyzing the relationship between startle measures and adaptive/maladaptive behaviors assessed with the Vineland Adaptive Behavior Scales (VABS) Second Edition. <b>Results</b>: Peak-ASR latency was negatively correlated with the VABS total score and socialization domain score of adaptive behaviors, while the ASR magnitude for relatively weak stimuli of 75-85 dB was positively correlated with VABS maladaptive behavior scores. Prepulse inhibition (PPI) at the prepulse intensity of 70-75 dB was also correlated with VABS maladaptive behavior. However, these relationships did not remain significant after adjustment for multiple comparisons. <b>Conclusions</b>: Our results indicate that the prolonged peak-ASR latency of ASD children might be associated with impairment in the developmental level of adaptive behavior, and that the greater ASR magnitude to relatively weak acoustic stimuli and smaller PPI of ASD children might increase the risk of maladaptive behavior. Future studies that have larger sample sizes will be important for further elucidating the neurophysiological factors that underpin adaptive as well as maladaptive behaviors in ASD.
Emulation of spline curves and its applications in robot motion control (1994)

The paper presents the design of a fuzzy controller to emulate spline curves for generating smooth motion trajectories. Spline models and a fuzzy control model are compared. Based on this comparison, a fuzzy control model is devised to make the robot continuously pass through the planned subgoals guiding the robot motion. By analyzing primitive movements along subgoals, the rule base can be developed. System structures are proposed for applying this fuzzy controller in the hierarchical motion control of robot systems. Its applications in robot arms and mobile robots are also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Viability of rat spermatogenic cells in vitro is facilitated by their coculture with Sertoli cells in serum-free hormone-supplemented medium. (1983)

Spermatogenic cells from 20- to 35-day-old rats were grown in vitro in the presence of Sertoli cells maintained in serum-free hormone/growth factor-supplemented medium and alternating high/low concentrations of follicle-stimulating hormone in the medium. In cell reaggregation experiments, spermatogenic cells reassociate with Sertoli cells but not with peritubular cells or cell-free substrate. Autoradiographic experiments using [3H]thymidine as a labeled precursor for DNA synthesis show that spermatogonia and preleptotene spermatocytes, connected by cytoplasmic bridges, have a synchronous S phase. [3H]Thymidine-labeled preleptotene spermatocytes progress until later stages of meiotic prophase. Time-lapse cinematographic studies of Sertoli/spermatogenic cell cocultures show three major movement patterns. While Sertoli cell cytoplasmic processes between adjacent cells display tensional forces, spermatogonia are engaged in oscillatory cell movements different from the nuclear rotation observed in meiotic prophase spermatocytes. Results of this study show that the proliferation of premeiotic cells and the differentiation of meiotic prophase cells do occur in vitro in association with Sertoli cells maintained in a medium that allows differentiated cell functions.
Hardware-Based ID, Rights Management, and Trusted Systems (2000)

Technologies involving the assignment and use of common user identifiers, such as Intel's ill-fated Processor Serial Number, provide a straightforward way for publishers to verify the authenticity of messages claiming authorization to receive digital works. These technologies are a useful adjunct to trusted systems, which allow content providers to prevent recipients from passing usable copies of the work to anyone who has not paid the content provider, and give content providers flexibility in specifying the nature of the event that will trigger a payment obligation. But their consequences are undesirable: Trusted systems relying on common identifiers will reduce anonymity and informational privacy on the Internet. They raise the prospect that a much larger proportion of ordinary transactions will require consumers to present unique identification numbers digitally linked to a wide range ofpersonally identifiable information. They are well-suited to being used across the board by a large number of unrelated information collectors, increasing the ease with which a wide range of information about a person can be aggregated into a single overall dossier.
Novel mutations in the CYP11B2 gene causing aldosterone synthase deficiency (2016)

Aldosterone synthase deficiency (ASD) is a rare, autosomal recessive inherited disease. Mutations in the CYP11B2 gene are responsible for the occurrence of ASD, and the clinical manifestations of ASD vary with age. Affected infants may develop symptoms of mineralocorticoid deficiency, including clinical presentation with frequent vomiting, a variable degree of hyponatremia, hyperkalemia, and metabolic acidosis combined with poor growth, which are easily confused with several other endocrine genopathies, including pseudohypoaldosteronism type 1 and congenital adrenal hyperplasia. In the present study, whole exome sequencing (WES) was used to screen for causal variants in the genome of a Chinese pediatric patient with confusing endocrine disorder symptoms. Clinical symptoms of frequent vomiting, hyponatremia and hyperkalemia were selected as the filtering indices to analyze the WES data. Clinically relevant variants were subsequently verified using Sanger sequencing. Minigene construct analysis was used to assess the consequence of a splicing variant in the CYP11B2 gene. The compound heterozygous mutations, c.1009C>T and c.240‑1G>A, in the CYP11B2 gene were identified and confirmed, and represented novel variants. Sequence analysis results revealed that the c.1009C>T mutation at codon 337 of exon 6 was a nonsense mutation, which led to early termination of the protein translation process. In addition, further investigation of the splicing pattern in a minigene construct showed that the c.240‑1G>A mutation led to the preservation of intron 1, with the 3'‑splice site disappearing during transcriptional processing of the mRNA. Using molecular genetic assessments, the patient was finally diagnosed with ASD. Therefore, the present study identified two novel CYP11B2 gene mutations in a Chinese patient with ASD, indicating exome sequencing as an effective diagnostic tool for rare endocrine-metabolic diseases.
Object-oriented technology for enhancing activity-based modeling functionality (2002)

Computer simulation is a powerful tool for analyzing and optimizing real-world systems with a wide range of successful applications. However, construction engineers have difficulty in mastering such techniques, particularly in modeling a construction process because existing simulation modeling methods require the user to manipulate many modeling elements in order to construct a simulation model for the process. The activity-based construction (ABC) modeling method provides an easy-to-use approach with one single element, e.g., activity, for modeling a construction process. This paper discusses the integration of object-oriented technology with ABC. The object-oriented technology allows each activity contain six classes of attributes describing the characteristics of the activity including duration, logical sequence, resource requirement, etc. These attributes are relevant to individual activities, and can be easily understood by an engineer who is familiar with the process. After incorporating these attributes, powerful modeling and simulation functions are realized. The integration greatly enhances the capability of ABC so that the enhanced ABC system has achieved both flexibility and ease-of-use essential for a construction simulation system.
Mitotic catastrophe induced by exposure of V79 Chinese hamster cells to low-energy protons (1999)

Mitotic catastrophe is persistent in the subsequent cell generations after proton and X irradiation of V79 cells; but protons are more effective than X-rays for the induction of this phenomenon. These results are discussed in terms of their importance in space exposures and possible acquisition of genomic instability by the progeny of irradiated cells.
An improved two-antenna direction of arrival (DOA) technique inspired by human ears (2008)

In this paper, we propose a novel human ears inspired DOA technique by placing a lossy scatter between two antennas, which introduces a large magnitude difference between the two received signals. The proposed technique can eliminate the ambiguity at high frequency caused by d Lt lambda/2 and achieve a better sensitivity. The effectiveness of this technique is demonstrated through several numerical examples. Future work will be concentrated on experimental demonstrations of high performance DOA systems using only two antennas.
A programmable rail-to-rail constant-g/sub m/ input structure for LV amplifier (2002)

We proposed a novel technique for low voltage rail-to-rail constant-g/sub m/ input stages, which does not depend on the operation regions of the MOS transistors. An op amp was designed to demonstrate the new idea using MOSIS AMJ 1.2 /spl mu/m technology. A 2.5 MHz unity-gain bandwidth with 61/spl deg/ phase margin was achieved when driving 10 k/spl Omega/ and 10 pF load, with 240 /spl mu/A current consumption and a power supply of 3 V. The g/sub m/ variation of the input stage is within /spl plusmn/3% from rail-to-rail. By changing the bias current, the unity-gain bandwidth could be programmed from 90 kHz to 3 MHz.
The modified step-wise deflation method in blood pressure measurement (2008)

In non-invasive blood pressure (NIBP) measurement, most of the automatic devices use oscillometric method. There are two types of deflation in oscillometric method. One is the linear deflation and the other is the stepwise deflation method. In this study, we suggest the modified step deflation to reduce the measurement time while keeping the advantage of step deflation over linear deflation. With the control of the valve and real time signal processing, we implemented the blood pressure measurement system and new algorithm. We measure the amplitude of each systolic pulsation. For the validation of our suggested method, human observer assessed SBP / DBP according to EHS (European Hypertension Society) guideline. The mean differences between the suggested method and traditional auscultation method were 1.95 mmHg for SBP and −0.55 mmHg for DBP.
[Dorsal approach and pi-shaped plate for treatment of distal radius fracture]. (2008)

Locking pi-shaped plate fixation is a reliable and effective method in the treatment of unstable fracture of distal radius.
Galactogogues: Medications That Induce Lactation (2002)

Galactogogues are medications that aid in initiating and maintaining adequate milk production. Most exert their pharmacologic effects through interactions with dopamine receptors, resulting in increased prolactin levels and thereby augmenting milk supply. Metoclopramide remains the galactogogue of choice due to its documented record of efficacy and safety in women and infants. Domperidone crosses the blood brain barrier and into the breast milk to a lesser extent than metoclopramide, decreasing the risk of toxicity to both mother and infant possibly making it an attractive alternative. Traditional antipsychotics, sulpiride and chlorpromazine, have been evaluated, but adverse events limit their use. Human growth hormone, thyrotrophin-releasing hormone, and oxytocin have also been studied. Finally, a natural product, fenugreek, has been purported to be effective in anecdotal reports. Use of this agent may be warranted after considering risks versus benefits.
An automated turbidimetric immunoassay for plasma proteins (1980)

The automated turbidimetric method presented allows a fast and accurate quantitation of plasma proteins. The analysis requires somewhat more antiserum than the radial immunodiffusion and the electroimmunoassay. However, this is compensated for by more rapid results and lower labour cost. The reference values for albumin, haptoglobin and IgG are the same as obtained by other immunological methods. The correlations with radial immunodiffusion and electroimmunoassay are good within the normal range. At high monoclonal IgG concentrations this method is better correlated to dye binding properties (scanning of electropherograms) than is the electroimmunoassay.
Das Lebenswerk F. E. Rühes und seine Beiträge zur Cladocerologie (1988)

The Life‐work of F. E. Rühe and his Contributions to Cladocerology F RIEDRICH E DUARD R ÜHE (born Febr. 9, 1888, died by war Sept. 22, 1915) was one of the most outstanding cladocerologists of the so‐called Berlin School of Cladocerology. In the years 1909–1915 R ÜHE published 10 papers, exclusively on Crustacea, in the majority on the bosminid species, arranged in the subgenus Eubosmina today (Crustacea: Cladocera, Bosminidae). Side by side with the papers by G. O. S ARS and W. L ILLJEBORG the main paper by R ÜHE (1912a) on Bosmina coregoni in the Baltic Lake District is a milestone in the research in bosminids. 75 years after he has published his papers they are quoted frequently in the international literature – an evidence for the great and unchanged importance of his work. It is the aim of the present paper to appreciate the papers and the thoughts of R ÜHE in a present day view on occasion of his centenary.
Cross platform approach for mobile application development: A survey (2016)

Nowadays, the use of mobile technologies is rising at an alarming scale. Due to this, more powerful and efficient mobile applications are needed in order to keep up with this trend. Since there exists several mobile platforms (iOS, Android, etc.), each one with different SDK (Software Development Kit) tools and specific development capabilities, application development becomes more complicated and expensive. The challenge is to come up with a solution that allows us to deploy in different platforms using a single SDK tool and maintaining the same performance as the native application. A suitable solution is cross-platform. In this paper, we present a survey of cross-platform creation approaches with an emphasis on the MDA (Model Driven Architecture) approach as it is one of the most promising cross platform approaches. We also identify and discuss the main desirable requirements of any cross-platform technology.
Coherently fed frequency scanning phased array structure for imaging applications (2012)

A coherently fed frequency scanning phased array structure for 1D imaging applications at F band is presented. The structure is being fabricated by conventional milling machine techniques. Improved results compared to frequency scanning leaky-wave antennas are obtained.
Application of singular value decomposition to vertical seismic profiling (1988)

Abstract An essential part of the interpretation of vertical seismic profiles (VSP) is the separation of the upgoing and downgoing waves. This paper presents a new approach which is based on the decomposition of time-shifted VSP sections into eigenimages, using singular value decomposition (SVD). The first few eigenimages of the time-shifted VSP section contain the contributions of the horizontally aligned downgoing waves. The last few eigenimages contain the contribution of uncorrelated noise components. The separated upgoing waves are recovered as a partial sum of the eigenimages.Important aspects of this approach are that regular sampling of the recording levels is not required, that the first-break times need not be measured with extreme accuracy, that noise rejection may be automatically included in the processing, and that eigenimages or sums of eigenimages which may be computed as part of the approach can provide important additional information.
Hybrid Feature based Natural Scene Classification using Neural Network (2012)

In this paper a classification for natural images is proposed using hybrid features. The objective of this paper is to develop an image content based classifier, which can perform identity check of a natural image. Here we have extracted wavelet and color features from a captured natural image to classify out of three groups. The developed technique is able to classify translation and rotation invariant matching among natural images using feed forward back propagation neural network. The database contains several hundreds of natural images of three groups namely coast, Forest, Mountain for classification and found good classification rate.
High spatial and temporal resolution mobile incoherent Doppler lidar for sea surface wind measurements (2008)

A mobile Doppler lidar based on an injection-seeded diode-pumped Nd:YAG pulsed laser with a high repetition rate was developed to measure the sea surface wind (SSW) with high spatial and temporal resolution. The system was operated during the 2007 Qingdao International Regatta to measure the distribution of SSW in the racing area in real time with 50-100 m horizontal resolution and 2-10 min temporal resolution. An observation of nonuniform distribution of SSW is presented. The lidar results are compared with both buoy and wind tower measurements, which show good agreement. This lidar can be used advantageously for the 2008 Olympic sailing games as well as for observing mesoscale and microscale meteorology processes.
In vitro effect of combinations of antimicrobial agents and EDTA-tromethamine on certain gram-positive bacteria. (1983)

Combinations of EDTA-tromethamine and 7 antimicrobial agents (chloramphenicol, nalidixic acid, oxytetracycline, penicillin, polymyxin-B, streptomycin, and a triple sulfonamide preparation) were tested for synergistic activities against Staphylococcus aureus, Corynebacterium renal, Listeria monocytogenes, Erysipelothrix rhusiopathiae, and a beta-hemolytic streptococci. Two in vitro tests were used--minimal inhibitory concentrations of the drugs and a 2-dimensional Microtiter checkerboard technique. A slight synergistic action was seen when L monocytogenes was exposed to combinations of penicillin-EDTA or streptomycin-EDTA.