gebhart/patrepeval huggingface dataset:
On the impact of 3D integration on high-throughput sensor information processing: A case study with image sensing (2013)

This paper presents a study for integrating a wavelet based image compression system in a 3D stack for wireless sensor node application. The high-bandwidth die-to-die interface from the vertical stacking of the sensor, the image buffer, and the signal-processing unit (SPU) is exploited for parallel processing. An image is divided into multiple segments, where each segment is compressed independently. However this method can negatively impact the compression ratio due to the length extension at the border of each segment. This paper explores the design space of the multi-segment architecture for the wavelet based image compression, including the number of segments, the operating frequency, and the supply voltage to reduce the power dissipation, and maintain a target image rate under varying channel condition. The effectiveness of the multi-segment implementation with 2D- versus 3D- integration is compared.
Abdominal CT findings in nephropathic amyloidosis of familial Mediterranean fever (2001)

To evaluate the abdominal CT features of reactive amyloidosis, abdominal CT scans of 20 patients with amyloidosis of familial Mediterranean fever (FMF) were reviewed and compared with abdominal CT scans of 2 control groups: 22 patients with chronic renal failure (CRF) due to non-amyloidotic kidney diseases and 40 patients with normal kidney function. The kidney size of patients with amyloidosis of FMF were found to vary during the course of the disease from normal or slightly larger than normal at the proteinuric phase, to smaller than normal and comparable to kidney size in CRF, at the uremic stage. Compared to kidney disease of other causes, more patients with FMF-amyloidosis had dense kidneys with coarse parenchymal calcification and calcification in other abdominal organs. Patients with FMF-amyloidosis had fewer aortic calcifications than patients with non-amyloidotic kidney disease. These findings suggest that kidney disease of reactive amyloidosis may have abdominal CT findings distinguishing it from other types of kidney diseases.
Optical Properties of Zincblende Cadmium Selenide Quantum Dots (2010)

Although wurtzite cadmium selenide quantum clots (wz-CdSe QDs) are one of the best explored colloidal nanomaterials, no detailed investigation of the optical properties of zincblende cadmium selenide quantum dots (zb-CdSe QDs) has been performed until now Typically, it is assumed that this material shows the same behavior as the wurtzite modification To investigate this, we present a study on the optical properties of zb-CdSe QDs, yielding the electronic hand gap to size relation (sizing curve), the extinction coefficient at short wavelengths, and the oscillator strength of the band gap transition Comparing these results with literature data on wz-CdSe QDs we observe, despite a deviation of the sizing curve for diameters above 4 urn, a similar extinction coefficient at stunt wavelengths and a smular oscillator strength
A hydrophobic gelatin fiber sheet promotes secretion of endogenous vascular endothelial growth factor and stimulates angiogenesis (2020)

In tissue engineering and regenerative medicine, the formation of vascular beds is an effective method to supply oxygen and nutrients to implanted cells or tissues to improve their survival and promote normal cellular functions. Various types of angiogenic materials have been developed by incorporating growth factors, such as vascular endothelial growth factor, in biocompatible materials. However, these exogenous growth factors suffer from instability and inactivation under physiological conditions. In this study, we designed a novel angiogenic electrospun fiber sheet (C16-FS) composed of Alaska pollock-derived gelatin (ApGltn) modified with hexadecyl (C16) groups to induce localized and sustained angiogenesis without growth factors. C16-FS was thermally crosslinked to enhance its stability. We demonstrated that C16-FS swells in phosphate-buffered saline for over 24 h and resists degradation. Laser doppler perfusion imaging showed that C16-FS induced increased blood perfusion when implanted subcutaneously in rats compared with unmodified ApGltn-fiber sheets (Org-FS) and the sham control. Furthermore, angiogenesis was sustained for up to 7 days following implantation. Immunohistochemical studies revealed elevated nuclear factor-κB and CD31 levels around the C16-FS implantation site compared with the Org-FS implantation site and the control incision site. These results demonstrate that C16-FS is a promising angiogenic material to promote the formation of vascular beds for cell and tissue transplantation without the need for growth factors.
Time-asymmetric initial data for the <i>N</i> black hole problem in general relativity (1984)

The time-asymmetric initial-value problem for N-body systems consisting of N black holes is described. The spacelike hypersurface for setting up the initial data is chosen to be the Einstein–Rosen manifold with N bridges. An explicit procedure in the form of an infinite series is given to construct solutions of the momentum constraints on the Einstein–Rosen manifold, starting from any solution of the momentum constraints in three-dimensional Euclidean space. A sufficient condition for the absolute convergence of a wide range of these solutions is derived. In particular, the solution representing N black holes with arbitrary momenta and spins is presented. The formulation of the Hamiltonian constraint as a boundary-value problem is discussed briefly.
ChemInform Abstract: LABORATORY AUTOMATION. 1: SYNTHESES VIA VINYL SULFONES. 14. ROBOTIC ORCHESTRATION OF ORGANIC REACTIONS: YIELD OPTIMIZATION VIA AN AUTOMATED SYSTEM WITH OPERATOR‐SPECIFIED REACTION SEQUENCES (1985)

Abstract Es wurde ein vollautomatisiertes, ‐ rechnergelenktes Roboterprogramm entwickelt, das bis zu 9 simultane Einzelreaktionen einschließlich Aufarbeitung durchführen kann.
Proposed dielectric-based microstructure laser-driven undulator (2008)

We describe a proposed all-dielectric laser-driven undulator for the generation of coherent short wavelengths and explore the required electron beam parameters for its operation. The key concept for this laser-driven undulator is its ability to provide phase synchronicity between the deflection force from the laser and the electron beam for a distance that is much greater than the laser wavelength. Because of the possibility of high-peak electric fields from ultrashort pulse lasers on dielectric materials, the proposed undulator is expected to produce phase-synchronous $\mathrm{GV}/\mathrm{m}$ deflection fields on a relativistic electron bunch and therefore lead to a very compact free electron based radiation device.
The Inositol Trisphosphate Receptor in the Control of Autophagy (2007)

The second messenger myo-inositol-1,4,5-trisphosphate (IP(3)) acts on the IP(3) receptor (IP(3)R), an IP(3)-activated Ca(2+) channel of the endoplasmic reticulum (ER). The IP(3)R agonist IP(3) inhibits starvation-induced autophagy. The IP(3)R antagonist xestospongin B induces autophagy in human cells through a pathway that requires the obligate contribution of Beclin-1, Atg5, Atg10, Atg12 and hVps34, yet is inhibited by ER-targeted Bcl-2 or Bcl-XL, two proteins that physically interact with IP(3)R. Autophagy can also be induced by depletion of the IP(3)R by small interfering RNAs. Autophagy induction by IP(3)R blockade cannot be explained by changes in steady state levels of Ca(2+) in the endoplasmic reticulum (ER) and the cytosol. Autophagy induction by IP(3)R blockade is effective in cells lacking the obligate mediator of ER stress IRE1. In contrast, IRE1 is required for autophagy induced by ER stress-inducing agents such a tunicamycin or thapsigargin. These findings suggest that there are several distinct pathways through which autophagy can be initiated at the level of the ER.
Characterization of an epoxy filler for piezocomposites compatible with microfabrication processes [Correspondence] (2011)

Miniature ultrasound transducer arrays that can operate at frequencies above 30 MHz are needed for high-resolution medical imaging. One way to achieve this is with a kerfless structure based on 1-3 connectivity piezocomposite with the electrodes defined by photolithography. To achieve this, not only does the composite need planar, parallel, and smooth surfaces, but it must also be made with an epoxy filler compatible with the chemicals, heat, and vacuum required for photolithography. This paper reports full characterization of an epoxy suitable for fine-scale kerfless array fabrication, including photolithographic processing. Material properties have been investigated as a function of cure temperature and for compatibility with solvents. By increasing the cure temperature, the crosslinking between the epoxy and the hardener in- creases, resulting in a higher glass transition temperature. The cured epoxy consequently has better resistance to both heat and solvents. An elevated cure temperature, near 100°C, is required to optimize material properties for photolithography on 1-3 piezocomposites. The acoustic properties of the epoxy have also been studied. These are similar to other epoxies used in piezocomposite fabrication and no significant changes have been observed for the different cure temperatures.
Functional Outcomes following Multiple Acute Rejections in Experimental Vascularized Composite Allotransplantation (2013)

Background: Vascularized composite allotransplantation has become a clinical reality. Patients undergoing vascularized composite allotransplantation have modest functional return. Most patients have had multiple acute rejections. The effect of multiple acute rejections influencing functional outcomes is unknown. This study systematically analyzes the effects of multiple acute rejections on functional outcome. Methods: Rat functional orthotopic hind-limb transplants were performed from Brown-Norway to Lewis rats. Group 1 consisted of isografts. In group 2, daily cyclosporine was administered to prevent acute rejection. In group 3, recipients did not receive regular immunosuppression but received only pulsed cyclosporine and dexamethasone to rescue acute rejection. The study endpoint was 90 days. Muscle and sciatic nerve biopsy specimens were taken for histologic analyses. Hind-limb function was assessed using sciatic nerve axon density, nerve conduction velocity, and muscle force generated by the gastrocnemius muscle. Novel video kinematics was used to analyze gait. Results: By the endpoint, group 3 animals had 17 ± 5.1 acute rejections. Muscle biopsy showed significant atrophy and fibrosis in group 3 compared with groups 1 and 2. Withdrawal to pin prick was evident by days 31 ± 1.2, 30 ± 2.3, and 31 ± 3.7 in groups 1, 2, and 3, respectively. At the endpoint, there was no significant difference in the axon density or nerve conduction velocity among the three groups, but muscle force generated was significantly less in group 3. Gait was abnormal in group 3 animals compared with other groups. Conclusions: In this study, multiple acute rejections induced muscle atrophy and fibrosis and consequent decreased function. This emphasizes the importance of preventing acute rejection to achieve optimum function following vascularized composite allotransplantation.
Diffractive optics technology and the NASA Geostationary Earth Observatory (GEO) (1992)

Diffractive (or binary) optics offers unique capabilities for the development of large-aperture, high-performance, light-weight optical systems. The Geostationary Earth Observatory (GEO) will consist of a variety of instruments to monitor the environmental conditions of the earth and its atmosphere. The aim of this investigation is to analyze the design of the GEO instrument that is being proposed and to identify the areas in which diffractive (or binary) optics technology can make a significant impact in GEO sensor design. Several potential applications where diffractive optics may indeed serve as a key technology for improving the performance and reducing the weight and cost of the GEO sensors have been identified. Applications include the use of diffractive/refractive hybrid lenses for aft-optic imagers, diffractive telescopes for narrowband imaging, subwavelength structured surfaces for anti-reflection and polarization control, and aberration compensation for reflective imaging systems and grating spectrometers.
Rapid Opening with Rigid Bone Parachute Mechanism (2020)

We developed Rigid Bone Parachute, which avoid tangling with using rigid bone link instead of wire. It can open rapidly and start deceleration earlier with spring. We performed drop test of Rigid Bone Parachute with two-wheel rover robot and confirmed its ability of avoidance of tangling. We measured its speed transition by motion capture and confirm its ability of rapid deceleration.
1 alpha,25-dihydroxyvitamin D3 regulates the transcription of carbonic anhydrase II mRNA in avian myelomonocytes. (1992)

Carbonic anhydrase II (CAII) is highly expressed in the osteoclast, where it is involved in the process of extracellular acidification required for bone resorption. We have previously shown that 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], a steroid hormone that regulates the differentiation of macrophages and osteoclasts, induces the expression of CAII mRNA and protein in avian bone marrow cells. To determine whether this regulation occurred at the gene level, we have studied the effects of 1,25(OH)2D3 on CAII expression in a transformed myelomonocytic avian cell line (BM2). As observed in nontransformed cells, 1,25(OH)2D3 markedly increased CAII biosynthesis and mRNA levels. The increase in CAII mRNA was detected as early as 3 hr after adding the hormone (1.9-fold) and reached 4.7-fold by 48 hr. These effects were completely blocked by actinomycin D, and nuclear run-on analysis confirmed that 1,25(OH)2D3 increased the rate of CAII gene transcription. In contrast, induction of CAII mRNA expression was not affected by inhibition of protein synthesis with cycloheximide, and no significant changes in mRNA stability were seen. Thus, 1,25(OH)2D3 modulates CAII gene expression at the transcriptional level, and this effect does not require de novo synthesis of other gene products. These results suggest that activation of the CAII gene occurs early in the differentiation events triggered by vitamin D3 in myelomonocytic cells.
Chromophore-assisted laser inactivation (CALI) to validate drug targets and pharmacogenomic markers (2000)

Functional proteomics directly addresses the role of proteins in cellular processes and thereby provides a basis for target validation for the development of therapeutics against particular diseases. Validated protein targets may serve as ideal pharmacogenomics markers. Chromophore-assisted laser inactivation (CALI) is a powerful tool for functional proteomics via protein inactivation with advantages of high spatial and temporal resolution. It also provides a complementary alternative to other inactivation strategies. It is hoped that future applications of CALI will accelerate the drug discovery process. In addition, CALI may be used to address problems associated with elucidating the function of multiple interacting genes through the use of multiple protein inactivations to show epistasis of complex cellular pathways. Drug Dev. Res. 49:65–73, 2000. © 2000 Wiley-Liss, Inc.
[Biotechnological aspects in "loco" larvae]. (1990)

The biology of planktotrophic larvae of Concholepas concholepas is the main bottleneck towards developing biotechnologies to rear this muricid. Data concerning planktonic larvae development, diets and environmental signals triggering larval settlement and recruitment is scarce. We have begun the study of the molecular and cell biology of embryos, larvae and recruits having as a final goal, the development of appropriate biotechnologies to rear this gastropod. First, an inverse ratio between BuChE and AChE enzyme activities was established. This ratio may be a precise developmental marker for this species. Second, for the first time a phosphoinositide related regulatory pathway is reported in a muricid, opening a new approach to the biotechnological management of larvae. Third, the relation between sulfate in sea water and larval motility was studied. Concentrations below 125 microM sulfate decreases larval motility. The sulfate is incorporated in proteoglycans which participate in different developmental phenomena. Lastly, a genomic Concholepas concholepas DNA sequence, similar to that of a human growth hormone probe was detected. This is very interesting since growth factors are key molecules during development, growth and are involved in food conversion rates in fish and also, in a variety of marine invertebrates.
Why Do Clinical Trials Fail? (2007)

Kobak, Kenneth A. PhD; Kane, John M. MD; Thase, Michael E. MD; Nierenberg, Andrew A. MD Author Information
Differential blood lipid-lowering effects of alkylsulfonated chitosan of different molecular weights in Syrian hamsters in vivo (2011)

This study investigated the effects of alkylsulfonated chitosan of different molecular weights on intestinal lipid absorption, blood lipid profiles and circulating adhesion molecules. Syrian hamsters were fed an AIN-93G-based high‑fat diet (HFD) and were orally administered 5 or 10 mg/kg BW of oligomer (6 kDa) chitosan (OC), low‑molecular-weight (70 kDa) chitosan (LMC) or high‑molecular-weight (200 kDa) chitosan (HMC) four times per week for 12 weeks. Animals receiving 2.5 mg/kg BW lovastatin (LOVA) served as a positive control. The blood lipid profiles of these control animals revealed that all chitosans and LOVA significantly decreased total triglyceride, total cholesterol, low‑density lipoprotein (LDL)-cholesterol and very‑low‑density lipoprotein (VLDL)-cholesterol levels in a dose‑dependent manner compared to the HFD-fed controls (P<0.05). The blood lipid lowering effectiveness of the three chitosans followed the order of LMC>OC>HMC. Hamsters receiving 5 and 10 mg/kg LMC (P<0.05) exhibited an increase in fecal fat content. Immunoblot assay revealed that acyl‑coenzyme A:cholesterol acyltransferase-2 (ACAT-2) expression was suppressed in all chitosan-fed animals compared to the HFD-fed controls (P<0.05). These results suggest that chitosan effectively decreases blood lipid content, and its effectiveness depends on the molecular size of chitosan. The hypolipidemic effect of chitosan is partly attributed to its suppression of intestinal lipid absorption and hepatic ACAT-2 expression.
452 Vibration and Noise Analysis in Consideration of Frame-Panel Vibration of the Drum Type Washing Machine (2008)

In a drum-type washing machine, when rotating speed exceeds 1000[rpm], the frame-panels cause elastic deformation and generate radiated noise. Recently, for the solution of such a problem, the researches used CAE are performed. In this work, first, we constructed a vibration analytical model that considered vibration mode of the frame-panel in order to evaluate the vibration and the radiated noise of a drum-type washing machine. Simulation results were quite similar to experimental results. Finally, using the constructed analytical model, design parameters tests to reduce the vibration of the machine subject were conducted. As a result, low-vibration design was proposed.
Book reviews (1975)

Change Without War. By Alastair Buchan. London: Chatto & Windus, 1974. 112 pp. £2.25. The End of the Postwar Era: A New Balance of Power. By Alastair Buchan. London: Weidenfeld & Nicolson, 1974. 347 pp. £4.25. The Use of Force in International Relations. By F. S. Northedge, Ed. London: Faber & Faber, 1974. 258 pp. £3.90. War and Moral Responsibility. By Marshall Cohen, Thomas Nagel and Thomas Scanlon, Eds. Princeton University Press, 1974. 182 pp. $2.95. Uncertain Passage: China's Transition to the Post‐Mao Era. By A. Doak Barnett. Washington, dc: The Brooking's Institution, 1974. 387 pp. $3.95. A Japanese View of Détente. By Hisahiko Okazaki. London and Lexington, Mass.: Lexington Books, D. C. Heath, for the Atlantic Council of the United States, 1974. 117 pp. No price quoted. A History of Air Power. By Basil Collier. New York: Macmillan, 1974. 358 pp. $10.95. The Thin Blue Line: International Peacekeeping and Its Future. By I. J. Rikhye, M. Harbottle and B. Egge. London and New Haven, Conn.: Yale UP, 1974. 353 pp. $12.50. Setting National Priorities. The 1975 Budget. By B. M. Blechman, E. M. Gramlich and R. W. Hartman. Washington, DC: The Brookings Institution, 1974. 268 pp. $2.95. Libya: The Elusive Revolution. By Ruth First. Harmondsworth: Penguin Books, The Penguin African Library, 1974. 293 pp. £0.70. The Israeli Army. By Edward Luttwak and Dan Horowitz. London: Allen Lane, 1975. 461 pp. £6.00. A History of the Israeli Army (1870–1974). By Zeev Schiff. San Francisco: Straight Arrow Books, 1975. 338 pp. $19.95. October Earthquake, Yom Kippur 1973. By Zeev Schiff. Tel Aviv: University Publishing Projects, 1974. 319 pp. with two map sketches. No price quoted.
Issues in ordered multicast performance: a simulation study (1996)

Process groups are an increasingly popular tool for programming distributed systems. Such groups consist of collections of processes that work together to provide reliability, fault tolerance, task distribution, or some other abstraction. A combination of group actions, reliable failure detection, and ordered message delivery are used to provide group functionality. {\em Causal ordering}, one form of message ordering, is fundamental in process group systems. Its cost is therefore an important determinant of overall performance. In order to gain more insight into the behavior of causal order protocols, two simulations of process group systems were developed. The first, a detailed simulation of all system processes, groups, and interconnection networks, was used to study small systems. Using this model, a number of parameters were identified as having the greatest impact on ordered multicast performance. These parameters were used as indices to a set of precomputed probability distribution tables used by the second simulation. The second simulation focused only on key processes --- packet originators and processes in multiple overlapping groups --- and used precomputed probability tables to reduce simulation overhead. Simulations using this model showed that the delays imposed by the ordering protocols result in a tendency for packets to become "convoyed" together. Consequences are larger delays and greater system and network burstiness. We speculate that this tendency for systems to become more bursty, or less uniform, is a general principle. That is, any system which delays actions on a "microscopic" level results in burstiness at a "macroscopic" level. The more times such delays occur, the greater the degree of burstiness. Such a principle would imply that systems with this characteristic are limited in scale by the size of the largest burst that can be handled. It also suggests that protocols that minimize the number and length of delays and which optimize the handling of bursts should be used. In the context of process group systems, burstiness can be limited by minimizing the number of groups through which a packet is filtered and by protocol designs which minimize the number of delays used to control out-of-order message arrival.