gebhart/patrepeval huggingface dataset:
Induction of Cytotoxicity, Aldehydic DNA Lesions, and Poly(ADP-Ribose) Polymerase-1 Activation by Catechol Derivatives of Pentachlorophenol in Calf Thymus DNA and in Human Breast Cancer Cells (2005)

The purpose of this study was to investigate the degree of chlorination of catechol (CAT) derivatives of pentachlorophenol (PCP) on the induction of cytotoxicity and DNA damaging effects in calf thymus DNA (ct-DNA) and in two human breast carcinoma cell lines. Results indicated that with the addition of the transition metal copper(II), increases in the amount of aldehydic DNA lesions (ADL) were detected in ct-DNA exposed to PCP-derived CATs over the corresponding control. The DNA lesions induced by various degrees of chlorination of PCP-derived CATs decrease in the rank order CAT congruent with 4-chlorocatechol (4-ClCAT) > 4,5-dichlorocatechol (4,5-Cl2CAT) > 3,4,5-trichlorocatechol (3,4,5-Cl3CAT) > tetrachlorocatechol (Cl4CAT). In contrast, Cl4CAT was the only congeneric form of PCP-derived catechols that induced a significant increase in the number of ADL in human MCF-7 cells, and this only occurred when glutathione was depleted. Pretreatment with copper(I) and iron(II) chelators significantly reduced the formation of ADL in cells exposed to Cl4CAT. The data also indicated that the ADL induced by Cl4CAT in MCF-7 cells contain approximately 70% putrescine excisable ADL. This evidence confirmed that the ADL induced by Cl4CAT in MCF-7 cells were derived from oxidative events. In addition, we demonstrated that the depletion of NAD(P)H in human T47D cells exposed to chlorinated CATs decreased in the rank order Cl4CAT >> 4-ClCAT congruent with CAT. The depletion of NAD(P)H induced by Cl4CAT in T47D cells was partially blocked by catalase, superoxide dismutase, dimethyl sulfoxide, and copper(I) and iron(II) specific chelators. Additionally, the depletion of NAD(P)H in T47D cells exposed to Cl4CAT (1-10 microM) was completely blocked by three types of poly(ADP-ribose) polymerase-1 inhibitors. This evidence suggests that Cl4CAT induces an imbalance in DNA repair and the subsequent accumulation of DNA strand breaks in human cultured cells. Overall, these findings indicate that dechlorination may decrease the potentials of chlorinated catechols to induce oxidative DNA lesions and cytotoxic effects in living cells.
Mechanistic Understanding of Rock/Phosphonate Interactions and the Effect of Metal Ions on Inhibitor Retention (2006)

This paper discusses the effects of Ca2+, Mg2+, and Fe2+ on inhibitor retention and release. Better understanding of phosphonate reactions during inhibitor squeeze treatments has direct implication on how to design and improve scale inhibitor squeeze treatments for optimum scale control. Putting various amounts of metal ions in the inhibitor pill adds another degree of freedom in squeeze design, especially in controlling return concentrations and squeeze life.Phosphonate reactions during squeeze treatments involve a series of self-regulating reactions with calcite and other minerals. However, excess calcite does not improve the retention of phosphonate due to the surface poisoning effect of Ca2+. The squeeze can be designed so that maximum squeeze life is achieved by forming a low solubility phase in the formation. Addition of Ca2+, Mg2+, and Fe2+ in the pill solution at 0.1 to 1 molar ratios significantly improves the retention of phosphonate. Alternatively, these metal ions can be dissolved from the formation while an acidic inhibitor pill is in contact with the formation minerals. Both BHPMP and DTPMP returns were significantly extended by the addition of metal ions, e.g. Ca2+ and Fe2+. The addition of Mg2+ may increase the long-term return concentration, which is important for some wells where a higher inhibitor return concentration is needed.The laboratory squeeze simulations were compared to two field return data obtained from squeeze treatments performed on two wells located in a sandstone reservoir in Saudi Arabia. The sandstone formation contains significant amounts of ironbearing minerals.
Electron and hydrogen atom transfer mechanisms for the photoreduction of o-quinones. Visible light-induced photoreactions of .beta.-lapachone with amines, alcohols, and amino alcohols (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron and hydrogen atom transfer mechanisms for the photoreduction of o-quinones. Visible light-induced photoreactions of .beta.-lapachone with amines, alcohols, and amino alcoholsXiaohong Ci, Rosaly Silveira da Silva, David Nicodem, and David G. WhittenCite this: J. Am. Chem. Soc. 1989, 111, 4, 1337–1343Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/ja00186a029https://doi.org/10.1021/ja00186a029research-articleACS PublicationsRequest reuse permissionsArticle Views769Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optical switching in the presence of two-photon absorption for a nonlinear directional coupler (1992)

We obtain solitary-wave solutions for a nonlinear directional coupler including the effects of strong two-photon absorption. These results show that complete optical switching is possible and the pulse shape and energy are preserved.
High Voltage SiC Vertical JFET for High Power RF Applications (2012)

We present the optimization of a standard lateral channel vertical JFET for high-frequency high-power applications. It will be shown that SiC JFETs are well suited to fulfill the requirements of certain RF applications when compared to silicon devices. Simulations covering the electrical characteristics will be given together with calculations considering the self-heating of the chip in pulsed-power applications and the corresponding decrease in saturation current. The gate-signal propagation will be analyzed for different chip layouts and the effect on switching speed will be described. Electrical results will demonstrate that the optimized JFET is suitable for RF-transmitter applications, like e.g. solid state RF modules as Klystron replacements in linear accelerators.
Epilogue (2007)

Introduction Fifteen years ago, the only option for patients with large abdominal aortic aneurysms (AAA) that required either elective or emergent repair was an open surgical approach using a transperitoneal or retroperitoneal incision. Now with the advent of endovascular approaches to aortic diseases, many patients, especially those in the high-risk groups, have a minimally invasive option to permit repair of aortic aneurysms, dissections, pseudoaneurysms, and ruptures.
3D Bioprinting of aortic structures with HDF cells (2014)

Traditionally, tissue engineering strategies for damaged or diseased large blood vessels are based on scaffolds. Following the cell-seeding and surgical implantation of scaffold, there could be immunogenic reactions and complications due to the limitations of scaffold biomaterials. Therefore, recent vascular tissue engineering studies tends to scaffold-free techniques [1, 2]. In this research, a novel biomimetic computer-aided design and three-dimensional (3D) bioprinting techniques are developed to optimize bioprinting of scaffold-free macrovascular structures biomimicking a real human aorta. Live human dermal fibroblast cells (HDF) aggregates and support structures (hydrogels) are 3D bioprinted layer-by-layer according to the developed self-supporting computer model to form biomimetic aortic vessel structures.
Microcontroller Programming and Interfacing: Texas Instruments MSP430 (2011)

This book provides a thorough introduction to the Texas Instruments MSP430 microcontroller. The MSP430 is a 16-bit reduced instruction set (RISC) processor that features ultra low power consumption and integrated digital and analog hardware. Variants of the MSP430 microcontroller have been in production since 1993. This provides for a host of MSP430 products including evaluation boards, compilers, and documentation. A thorough introduction to the MSP430 line of microcontrollers, programming techniques, and interface concepts is provided along with considerable tutorial information with many illustrated examples. Each chapter provides laboratory exercises to apply what has been presented in the chapter. The book is intended for an upper level undergraduate course in microcontrollers or mechatronics but may also be used as a reference for capstone design projects. Also, practicing engineers already familiar with another microcontroller, who require a quick tutorial on the MSP430, will find this book very useful.
Optical networking using micromachines (2002)

Summary form only given. Progress in optical networks is driven by the shift from voice messaging to data communications and an exponential growth in capacity demands. New micromachine devices (MEMS) are poised to significantly impact the advancement of both networking and transmission. The deployment of MEMS based optical cross connects allow network flexibility in the optical domain and open the path to optical layer networking. Optical wavelength add-drop switches are a key components in the emerging ultra long haul (>2000km) transmission systems and will expand the optical layer traffic management.
ChemInform Abstract: Indium(III)‐Catalyzed Reductive Monoalkylation of Electron‐Rich Benzenes with Aliphatic Carboxylic Acids Leading to Arylalkane Derivatives. (2015)

Abstract A one‐pot monoalkylation of benzene derivatives with aliphatic carboxylic acids having a variety of substituents with a combination of InI 3 , hydrosilane, and molecular iodine is reported.
What Controls Regiochemistry in 1,3-Dipolar Cycloadditions of Münchnones with Nitrostyrenes? (2013)

The distinct experimentally observed regiochemistries of the reactions between mesoionic münchnones and β-nitrostyrenes or phenylacetylene are shown by DFT/BDA/ETS-NOCV analyses of the transition states to be dominated by steric and reactant reorganization factors, rather than the orbital overlap considerations predicted by Frontier Molecular Orbital (FMO) Theory.
Controlled Orientation and Morphology of High Modulus and High Strength Fibers. (1996)

高分子の配向.配列制御技術の近年のもっとも大きな実りのひとつは.液晶紡糸.ゲル紡糸といった高強度.高弾性率繊維の製造技術である.これらの繊維化技術のキーテクノロジーは流動.伸長場による配向制御であり.本稿では.こうした外場中での高分子の構造形成に関する最近の話題を概説した.
Initial Characterization of a Subclone of the MA-10 Mouse Leydig Tumor Cell Line* (1989)

Cloned cell lines have proven to be useful models in understanding the regulation of endocrine cells and steroid synthesis. In this study we report the isolation and characterization of a subclone of the MA-10 Leydig tumor cell line. Whereas there was no difference in basal steroid production between the clone (MA-10 LP) and the parent stock (MA-10), MA-10 LP produces very low levels of progesterone after stimulation by hCG or (Bu)2cAMP. In both cell populations, hCG stimulation resulted in the accumulation of comparable amounts of cAMP in the presence of a phosphodiesterase inhibitor, and similar levels of cAMP were measured at 30 min without inhibitor. Measurement of cholesterol side-chain cleavage activity using two separate methods demonstrated that the low steroid production in MA-10 LP could not be accounted for by a decrease in the activity of this enzyme complex. Additionally, no difference in 3 beta-hydroxysteroid dehydrogenase activity could be demonstrated between the two cell populations. Since the lesion that attenuates the ability of MA-10 to synthesize progesterone is somewhere after the production of cAMP and before cholesterol side-chain cleavage activity, this system may provide a useful model for understanding the regulatory mechanisms controlling steroid biosynthesis in Leydig cells.
Injection Pharyngoplasty With Calcium Hydroxyapatite for Treatment of Velopalatal Insufficiency (2008)

The data from this small series suggest that posterior pharyngeal wall injection with calcium hydroxylapatite is safe and may be effective in treating select patients with VPI. Further longitudinal studies, with a larger series of patients, examining the safety, efficacy, and patient selection are warranted to better understand the possible use of posterior pharyngeal wall injection of calcium hydroxylapatite in children with symptomatic VPI.
Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve (2005)

The immune system in vertebrates senses exogenous and endogenous danger signals by way of complex cellular and humoral processes, and responds with an inflammatory reaction to combat putative attacks. A strong protective immunity is imperative to prevent invasion of pathogens; however, equivalent responses to commensal flora and dietary components in the intestine have to be avoided. The autonomic nervous system plays an important role in sensing luminal contents in the gut by way of hard-wired connections and chemical messengers, such as cholecystokinin (CCK). Here, we report that ingestion of dietary fat stimulates CCK receptors, and leads to attenuation of the inflammatory response by way of the efferent vagus nerve and nicotinic receptors. Vagotomy and administration of antagonists for CCK and nicotinic receptors significantly blunted the inhibitory effect of high-fat enteral nutrition on hemorrhagic shock-induced tumor necrosis factor-alpha and interleukin-6 release (P < 0.05). Furthermore, the protective effect of high-fat enteral nutrition on inflammation-induced intestinal permeability was abrogated by vagotomy and administration of antagonists for CCK and nicotinic receptors. These data reveal a novel neuroimmunologic pathway, controlled by nutrition, that may help to explain the intestinal hyporesponsiveness to dietary antigens, and shed new light on the functionality of nutrition.
Soluble copper(I) catalysts for the formation of aryl-carbon and aryl-nitrogen bonds. (2001)

U92-U92
Genipatriol, a New Cycloartane Triterpene from <i>Genipa spruceana</i> (2003)

Genipatriol (1), a new 2alpha,3beta-dihydroxylated cycloartane triterpene, was isolated from the aerial parts of Genipa spruceana. The structure of genipatriol was determined by a combination of spectroscopic methods.
A crystal-controlled microwave oscillator (1956)

Thesis (M.S.) Massachusetts Institute of Technology. Dept. of Electrical Engineering, 1956.
Pseudo-linear operation of second-order phase-locked loops (1981)

This paper defines a region of operation, calling it the pseudo-linear region, where a phase-locked loop (p.l.l.), behaves essentially in a linear manner. The results obtained for a loop with an active second-order filter suggest a very simple empirical definition for this region as a function of the parameters of the loop (ζ, and ωn), and classifies the regions of operation of the p.l.l., linear, pseudo-linear, non-linear and cycle slipping.
ChemInform Abstract: STUDIES ON THE CONVERSIONS OF DIOLS AND CYCLIC ETHERS. I. INVESTIGATION OF PART‐STEPS IN THE DEHYDRATION AND FRAGMENTATION OF 1,3‐DIOLS ON A COPPER CATALYST (1982)

Abstract Anhand der Modellverbindungen 1,3‐Butandiol und 2‐Methyl‐2,4‐pentandiol sowie auch einiger Intermediärverbindungen der Dehydratisierung wird gezeigt, daß die Reaktion je nach Molekülstruktur und Reaktionsführung auf zwei unterschiedlichen Wegen zu verschiedenen Produkten führen kann.
European MCL Network: An Update on Current First Line Trials. (2007)

Abstract Background: Conventional chemotherapy achieves only short term remission despite high initial response rates of 70%–80%. In the current study generation, the European MCL Network investigates the impact of various combined immuno-chemotherapy regimens. Additionally, in elderly patients the role of rituximab maintenance is being evaluated, whereas in younger patients dose-intensified regimens with implementation of high dose cytarabine are investigated based on the excellent results of the HyperCVAD regimen. Methods: In MCL elderly, patients are initially randomized between 8 cycles of R-CHOP or 6 cycles of R-FC (experimental arm). Patients who achieve either an PR or CR, receive subsequently either interferon maintenance (standard arm) or a single rituximab dose every 2 months. In MCL younger, the standard arm (R-CHOP induction followed by myeloablative consolidation: 12 Gray TBI, 2x 60mg/kg cyclophosphamide) is compared to the implementation of high dose cytarabine into induction (R-CHOP/R-DHAP) and consolidation (10 Gray TBI, 4x1,5 g/m2 Ara-C, 140mg/m2 melphalan). Results: In MCL elderly, 222 of 263 patients were evaluable based on the annual interim analysis. Median age was 70 years with 66% of patients displaying an intermediate high/high risk IPI. Induction was well tolerated with mainly hematological toxicity (grade III/IV in R-CHOP/R-FC): Leukocytopenia 62/72%, thrombocytopenia 13%/40%, but only rare febrile neutropenia (23%/7%) or infections (19%/23%). Despite the poor risk profile, combined immuno-chemotherapy (total group) achieved a remarkable 84% response rate (51% CR/CRu). Although the impact of maintenance is not yet evaluable, both progression-free and overall survival were encouraging with 77% and 86% at 12 months, respectively. In MCL younger, 247 of 271 patients were evaluable. Again, toxicity (grade III/IV in R-CHOP/alternating R-DHAP) was mainly hematological: leukocytopenia 58/77%, thrombocytopenia 14%/74%, but only rare febrile neutropenia (11%/22%) or infections (5%/7%). Combined immuno-chemotherapy achieved a 93% response rate (60% CR/CRu) before subsequent high dose consolidation. Again, both progression-free and overall survival are remarkable with both 90% at 12 months, respectively. Discussion: Combined immuno-chemotherapy results in high response rates in two prospective international trials. Further recruitment and follow-up will determine the role of rituximab maintenance and high dose cytarabine in this distinct subtype of malignant lymphoma.
Improving ECG diagnostic classification by combining multiple neural networks (2002)

Recent research has shown that combining multiple versions of unstable classifiers such as neural networks results in reduced test set error. By resampling from the original training set, modified training sets are formed and used to train separate neural network classifiers. The outputs of these classifiers are then combined by voting. Bagging is one of the more simple techniques of resampling and involves sampling with replacement from the training set and combining the network outputs with equally weighted voting. Other more sophisticated techniques adaptively resample the training data and give additional weights to cases which have previously been misclassified. The authors applied a number of these techniques to the problem of ECG diagnostic classification and sound an improvement of greater than 10% in overall classification rate was readily achievable.
[Atrioventricular block induced by radiofrequency: electrophysiological criteria of success]. (1993)

In a retrospective series of 18 consecutive patients (10 men, average age: 61.6 +/- 9.2 years) who underwent His bundle ablation by radiofrequency current, the authors analyzed the electrophysiological criteria predictive of complete atrioventricular block. A total of 82 radiofrequency bursts were analyzed (average: 4.5 +/- 3.1 bursts/patient) and classified as effective (N = 14, definitive atrioventricular block), ineffective (N = 55, no effect on atrioventricular conduction) or transiently effective procedures (N = 13, reversible Mobitz II atrio-ventricular block). Seven electrophysiological parameters were measured: HV interval, amplitude of atrial (A), Hisian (H) and ventricular (V) potentials, and the A/H, A/V, and V/H ratios before each radiofrequency burst. At the end of the ablation, 14 patients were in complete atrioventricular block and during the following 24 hours, a complete atrioventricular block developed in 3 other patients. The average value of the H potential was comparable in the effective and transiently effective procedures (0.28 +/- 0.20 mV and 0.27 +/- 0.19 mV respectively) and significantly higher than the same parameters in the ineffective group of procedures (0.65 +/- 0.14 mV, p = 0.008). The V/H ratio was progressively greater in effective (5.43 +/- 2.51), transiently effective (8.07 +/- 6.90) and ineffective procedure (14.32 +/- 13.35), p = 0.02; the average value of the A amplitude tended to be higher in the effective procedures (1.03 +/- 0.75 mV) and the transiently effective procedures (0.98 +/- 0.72 mV) than in the ineffective procedures (0.58 +/- 0.79 mV), p = 0.06. On the other hand, the other parameters were comparable in the three groups of patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Real-time segmentation architecture of gray-scale/color motion pictures and digital test-chip implementation (2003)

This paper proposes a digital algorithm for gray-scale/color image segmentation of real-time video signals and a cell-network-based implementation architecture in state-of-the-art CMOS technology. Through extrapolation of test-chip-data design in 0.35 /spl mu/m CMOS technology and simulation results we predict that about 50,000 /spl sim/ 100,000 pixels can be integrated on a chip in a 0.09 /spl mu/m CMOS technology, realizing very high-speed segmentation at about 300 /spl mu/sec per gray-scale/color image. Consequently real-time color-video segmentation will become possible in near future.
Improved mercury arc lamps (1978)

The devitrification problem of capillary high pressure mercury lamps is shown to be caused by impurities in the natural quartz. It is shown that this problem may be solved by using synthetic quartz of low OH-content. An improvement of lamp life by an order of magnitude appears to be possible.
Self‐Assembled Nanoscale Ring Arrays from a Polystyrene‐<i>b</i>‐polyferrocenylsilane‐<i>b</i>‐poly(2‐vinylpyridine)Triblock Terpolymer Thin Film (2009)

Hollow ring arrays with an outer and inner diameter of 33 and 11 nm, respectively, are formed from a thin film of poly-(styrene-b-ferrocenylethylmethylsilane-b-2-vinyl pyridine) (PS-b-PFS-b-P2VP) triblock terpolymer with a core/shell cylindrical morphology. The PS minority block forms a core surrounded by a PFS shell in a P2VP matrix; the core/shell structure is oriented perpendicularly to the film surface. The PS core and P2VP matrix blocks are partly removed using oxygen reactive ion etching, leaving ring patterns made from oxidized PFS. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Jean Orcibal. La rencontre du Carmel thérésien avec les mystiques du Nord (1961)

Cognet Louis. Jean Orcibal. La rencontre du Carmel thérésien avec les mystiques du Nord. In: Revue d'histoire de l'Église de France, tome 47, n°144, 1961. pp. 263-264.