gebhart/patrepeval huggingface dataset:
Correlation of shedding cryptic epitope (HU177) levels and treatment response in sera of melanoma patients (2008)

20018 Background: We have previously shown that shedding of the recently identified cryptic epitope HU177 can be measured in melanoma patients’ sera and correlates with invasiveness of primary melanomas. Here we prospectively measured HU177 collagen epitope (HCE) titers in sera of stage IV melanoma patients (pts) enrolled in two clinical trials conducted at our institution. Methods: Serum samples from 37 pts (11-M1a, 10-M1bM, 16-M1c) who received Sorafenib on an NCI phase II trial (6617) (study A) and from 18 stage IV pts who were treated 2nd line with Carboplatin, Paclitaxel, and PABA on a phase I trial (study B), were analyzed for HCE by a dual sandwich ELISA during each of up to 12 cycles. Serum was aliquoted into 200 μl volumes and stored at - 20°C until assayed. Correlation of HCE levels with treatment response as measured by PET/CT or CT imaging was examined. Results: In 2 of 3 radiographically responding pts in study A correlation with HCE was seen. In one pt, HCE levels dropped from 74.4 ng/ml to undetectable by cycle 2. Another pt who had a response that lasted >200 days, HCE titers progressively decreased from 55.1 to 15.8 ng/ml over the first 3 cycles (71.5% drop) and subsequently remained in the range from 0 - 9.7 ng/ml from cycle 4 to cycle 7 (mean decrease (± SD) from baseline of 89.6±6.1% below pre-treatment levels). During this time, the mean standard uptake values (SUV) measured in PET/CT scans decreased from 11.3 (pre-treatment) to 4.3 and 2.3, respectively. In study B, 4 of 6 responders demonstrated a drop in HCE titers that correlated with treatment response. For example, one patient had HCE levels decrease from 54.0 ng/ml to 30.2 ng/ml by cycle 1 and remained in the range from 20.6 ng/ml to 41.1 ng/ml from cycle 2 to cycle 9 (mean 38.6±12.0 % below pre-treatment levels) while serial CT imaging demonstrated continued treatment response lasting > 200 days. Conclusions: Our data demonstrate, in two separate trials, the utility of serial HCE measurements for the monitoring of therapeutic responses in metastatic melanoma pts. Since the assay is not tumor-type specific, it may not only prove useful in future melanoma studies, but other cancer trials as well. No significant financial relationships to disclose.
Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis (2013)

Overall, from both macroscopic and microscopic data of this study indicate the injectable HA-DOX hydrogels presented as a long-lasting pharmacotherapeutic agent to apply for OA therapy.
Packed Bed Liquid Phase Dispersion in Pulsed Gas-Liquid Downflow (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPacked Bed Liquid Phase Dispersion in Pulsed Gas-Liquid DownflowJan. J Lerou, David Glasser, and Dan LussCite this: Ind. Eng. Chem. Fundamen. 1980, 19, 1, 66–71Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/i160073a011https://doi.org/10.1021/i160073a011research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Different Roles of Flowering-Time Genes in the Activation of Floral Initiation Genes in Arabidopsis (1997)

, , Mark Wilkinson, George Haughn, Julio Salinas, , Different Roles of Flowering-Time Genes in the Activation of Floral Initiation Genes in Arabidopsis, The Plant Cell, Vol. 9, No. 11 (Nov., 1997), pp. 1921-1934
Urinary 6 beta-hydroxycortisol/cortisol ratios measured by high-performance liquid chromatography for use as a biomarker for the human cytochrome P-450 3A4. (1993)

Cortisol is metabolized to 6 beta-hydroxycortisol by the human cytochrome P-450 3A4, an enzyme implicated in the critical epoxidation reactions of aflatoxin B1 and certain polycyclic aromatic hydrocarbons. A method has been developed to measure the 6 beta-hydroxycortisol:cortisol ratio in human urine by reverse-phase high-performance liquid chromatography using diode-array detection. This method permits measurement of both cortisols in a single chromatographic run and has the potential to measure other metabolites useful for the determination of other human cytochrome P-450 activities. Using the 6 beta-hydroxycortisol:cortisol ratio as a marker of cytochrome P-450 3A4 activity adjusts for the circadian fluctuation in cortisol levels, providing a determination that is consistent over a 24-h period, obviating the need for 24-h urine collections. This high-performance liquid chromatography technique was used for the analysis of 14 different human urines and a range of ratios of 1.6 to 21.7 (mean +/- SE, 6.2 +/- 1.6) was found. These values are consistent with those reported in the literature. This method should be useful in molecular epidemiological studies investigating relationships between the susceptibility from environmental carcinogen exposure and cancer risk.
X-ray Absorption Near Edge Studies of Cytochrome P-450-CAM, Chloroperoxidase, and Myoglobin (1995)

The low spin ferric and low and high spin ferrous forms of myoglobin, bacterial cytochrome P-450-CAM, and chloroperoxidase have been examined by Fe-K x-ray absorption edge spectroscopy. The positions of the absorption edge and the shapes of preedge and edge regions of imidazole adducts of ferric P-450-CAM and chloroperoxidase are essentially the same when compared with thiolate-ligated ferric myoglobin. As these three protein derivatives all have six-coordinate, low spin, ferric hemes with axial imidazole and thiolate ligands, the superposition of x-ray absorption edge spectral properties demonstrates that the protein environment does not effect the spectra, provided one compares heme iron centers with identical coordination numbers, spin and oxidation states, and ligand sets. In contrast, a 0.96 eV difference is observed in the energy of the absorption edge for imidazole- and thiolate-ligated ferric myoglobin with the latter shifted to lower energy as observed for ferrous myoglobin states. Similarly, in the low spin ferric-imidazole and ferrous-CO states, the energies of the absorption edge for chloroperoxidase and P-450-CAM are shifted in the direction of the ferrous state (to lower energy) when compared with those for analogous myoglobin derivatives. In the deoxyferrous high spin state, comparison of the edge spectra of chloroperoxidase with analogous data for cytochrome P-450-CAM suggests that the electron density at the iron is similar for these two protein states. The shifts observed in the energies of the x-ray absorption edge for the thiolate-ligated states of these proteins relative to derivatives lacking a thiolate ligand provide a direct measure of the electron releasing character of a thiolate axial ligand. These results therefore support the suggested role of the cysteinate proximal ligand of P-450 as a strong internal electron donor to promote O-O bond cleavage in the putative ferric-peroxide intermediate to generate the proposed ferryl-oxo "active oxygen" state of the reaction cycle.
Complex seismic decomposition - Application to pore pressure prediction (1993)

The commom approach to pore pressure prediction is made in two main steps: (1)-determine the depth intervals wich contain mainly shale, (2)-evaluate the deviation in the petrophysical properties of the shale from the trend of normal compaction (e.g. Tertzaghi & Peck, 1948). Several alternative methods of velocity estimation from surface seismic data are usually employed at the second step (E.Penibaker, 1968). Some of the methods such as RMS velocity analysis, have low resolution. Other methods such as Pseudo Acoustic lmpedance transformation, do not provide the low frequency components which implies that the overall compaction trend for the shale sequences cannot be determined with sufficient accuracy. Furthermore, velocity based methods do not involve lithological subdivisions (i.e. step 1)
Performance at slaughter and beef quality characteristics of some mediterranean beef breeds compared to central and north european breeds (GemQual EU Project) (2006)

International audience
09192 Abstracts Collection – From Quality of Service to Quality of Experience (2009)

From 05.05. to 08.05.2009, the Dagstuhl Seminar 09192 ``From Quality of Service to Quality of Experience'' was held in Schloss Dagstuhl~--~Leibniz Center for Informatics. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The first section describes the seminar topics and goals in general. Links to extended abstracts or full papers are provided, if available.
Polarization and retinal image quality estimates in the human eye (2001)

We have previously studied how polarization affects the double-pass estimates of the retinal image quality by using an imaging polarimeter [Opt. Lett. 24, 64 (1999)]. A series of 16 images for independent combinations of polarization states in the polarimeter were recorded to obtain the spatially resolved Mueller matrices of the eye. From these matrices, double-pass images of a point source for light with different combinations of incoming (first-pass) and outcoming (second-pass) polarization states were reconstructed and their corresponding modulation transfer functions were calculated. We found that the retinal image or, alternatively, the ocular aberrations, are nearly independent of the state of polarization of the incident light (in the first pass). This means that a significant improvement in the ocular optics by using a specific type of polarized light could not be achieved. However, quite different estimates of the retinal image quality are obtained for combinations of polarization states in both the first and the second passes in the double-pass apparatus.
Acetabular Fractures (1999)

Sixty patients with acetabular fractures were treated surgically. All fractures were a result of high energy trauma, most with significant associated injuries. Fifty-three of the patients were followed up for at least 2 years. Clinical outcome was analyzed clinically using the Harris hip score and radiographically. In 41 (77.4%) of the patients, the surgical procedure was judged successful (Harris hip score greater than 80 points). Three factors were found to be statistically significant predictors of such an outcome: patient age younger than 40 years; simple fractures based on the classification of Letournel and Judet; and absence of damage to the femoral head. Possible influential factors that were not found to be statistically significant in this population included additional injuries, immediate complications, quality of reduction, heterotopic ossification, ipsilateral femoral fracture, and sciatic nerve damage. Open reduction and internal fixation of the displaced acetabular fracture, although a demanding procedure, can result in a satisfactory clinical outcome given a consistent approach with a dedicated team.
Synthesis and Cytotoxic Activity of Pentacyclic Triterpenoid Sulfamates (2015)

Methyl triterpenoates derived from oleanolic, ursolic, betulinic, glycyrrhetinic, platanic, or maslinic acid were converted into their corresponding sulfamates and carbamoylsulfamates. The sulfamates were screened in photometric sulforhodamine assays for cytotoxic activity employing several human tumor cell lines. Many of the compounds showed EC50 values in one-digit μM concentration. Of special interest seems methyl (3β) 3-(aminosulfonyloxy)-11-oxo-oleanoate (18) showing good cytotoxicity for the human adenocarcinomic alveolar basal epithelial cell line A549 while being less toxic for non-malignant NIH 3T3 mouse fibroblasts.
A Continuous Cryogenic Diffusion Pump For Fusion Reactors (2005)

A pumping system designed to pump magnetic fusion reactors has been operated pumping deuterium, hydrogen and hydrogen-helium mixtures. A 500 mm bore liquid helium cooled "snail" cryocondensation pump was used to pump the hydrogen species. The snail pump is equipped with a unique regeneration head which continuously removes the hydrogen ice from the cryocondensation surfaces while the pump is in operation. The hydrogen ice is evaporated inside the snail head and pumped with a 500 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /h roots blower. The snail cryopump is attached to a 500 mm boretimes3 m long liquid nitrogen cooled entrance duct. The "cold duct" provides several important functions of the pumping system, it: 1) provides the conduit between the diverter and the cryopump, 2) pre-cools the gases allowing the elimination of a restrictive entrance baffle, 3) reduces the molecular mean free path allowing the duct to operate in the fluid flow regime. The fluid flow regime increases conductance and allows compression of the helium stream by diffusive drag. With the large compression of the helium, it can be pumped with a conventional turbomolecular pump. The cryopump effectively strips the hydrogen species from the helium stream before it enters the turbomolecular pump. The pumping system thereby separates the hydrogen and helium streams. Mass flow controllers were used to inject the hydrogen (deuterium) and helium into a standard AVS test dome fitted with a capacitance manometer. Pure hydrogen was pumped at flow rates from 1.7 to 67.4 Pam <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /s (the limit of the flow system) with the test dome pressure varying from 0.1 to 0.52 Pa, the effective pumping speed varied from 17 to 129 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /s which is in good agreement with Poiseuille flow. Deuterium was pumped at rates up to 33.6 Pam <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /s, at 0.39 Pa, pumping speed 86 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /s. Pure helium was pumped to0.32 Pam <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /s at .49 Pa, pumping speed 0.67 mVs. Hydrogen with 1% helium was pumped to 32.7 Pam <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /s at 0.52 Pa, effective pumping speed of both species was 63 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /s. The helium compression varied from 31 up to 93 at the maximum flow. The flow was limited by the pumping capacity of the turbomolecular pumps. The design of the pumping systems, the test results and comparisons to fluid flow theory is presented
Middle adolescents' views of war and American military involvement in the Persian Gulf. (1993)

A sample of 189 eleventh graders in three different school locations (rural, urban, and suburban) was surveyed in order to (a) assess the effects of such variables as school setting, race, and gender on attitudes toward war; (b) examine attitudes toward the Persian Gulf War in relation to attitudes toward war in general; and (c) compare present-day attitudes with those identified in earlier studies concerning Vietnam and Latin America. While reactions to war were found to be associated with gender, race, and school setting, students in the present study were slightly less supportive of war in general, but more supportive of the Gulf War than were past subjects of the conflicts of their day.
Successive refinement lattice vector quantization (2002)

Lattice Vector quantization (LVQ) solves the complexity problem of LBG based vector quantizers, yielding very general codebooks. However, a single stage LVQ, when applied to high resolution quantization of a vector, may result in very large and unwieldy indices, making it unsuitable for applications requiring successive refinement. The goal of this work is to develop a unified framework for progressive uniform quantization of vectors without having to sacrifice the mean- squared-error advantage of lattice quantization. A successive refinement uniform vector quantization methodology is developed, where the codebooks in successive stages are all lattice codebooks, each in the shape of the Voronoi regions of the lattice at the previous stage. Such Voronoi shaped geometric lattice codebooks are named Voronoi lattice VQs (VLVQ). Measures of efficiency of successive refinement are developed based on the entropy of the indices transmitted by the VLVQs. Additionally, a constructive method for asymptotically optimal uniform quantization is developed using tree-structured subset VLVQs in conjunction with entropy coding. The methodology developed here essentially yields the optimal vector counterpart of scalar "bitplane-wise" refinement. Unfortunately it is not as trivial to implement as in the scalar case. Furthermore, the benefits of asymptotic optimality in tree-structured subset VLVQs remain elusive in practical nonasymptotic situations. Nevertheless, because scalar bitplane- wise refinement is extensively used in modern wavelet image coders, we have applied the VLVQ techniques to successively refine vectors of wavelet coefficients in the vector set-partitioning (VSPIHT) framework. The results are compared against SPIHT and the previous successive approximation wavelet vector quantization (SA-W-VQ) results of Sampson, da Silva and Ghanbari.
Dimerization energetics of benzene and aromatic amino acid side chains (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDimerization energetics of benzene and aromatic amino acid side chainsS. K. Burley and G. A. PetskoCite this: J. Am. Chem. Soc. 1986, 108, 25, 7995–8001Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/ja00285a019https://doi.org/10.1021/ja00285a019research-articleACS PublicationsRequest reuse permissionsArticle Views512Altmetric-Citations230LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: DIVINYL SULFIDE. VIII. REACTIONS OF ACETYLENE WITH HYDROGEN SULFIDE IN ALKALI‐DIMETHYL SULFOXIDE AND ALKALI‐HEXAMETHYLPHOSPHOROTRIAMIDE SYSTEMS (1982)

Abstract Die Reaktion von Acetylen (I) mit H 2 S in Gegenwart von Alkalihydroxid und DMSO liefert je nach Reaktionsbedingungen wechselnde Ausb. an Divinylsulfid (II).
Conducting atomic-force-microscope electrical characterization of submicron magnetic tunnel junctions (2003)

We have developed the ability to electrically characterize submicron magnetic tunnel junctions using a conducting atomic force microscope (CAFM). This technique can be applied after only a short processing route, thereby saving time and resources, and reducing the potential for damaging the junctions. The CAFM can be used to measure hysteresis loops, magnetoresistance, resistance–area product, switching astroids, current–voltage curves, and breakdown voltage of tunnel junctions. In this letter, we outline the sample requirements, detail the CAFM processing route, describe tip preparation, and report examples of data we have obtained with this technique over the last two years.
High performance liquid chromatographic determination of theophylline metabolites in human liver microsomes (1991)

A high performance liquid chromatographic (HPLC) technique for the determination of three metabolites of theophylline, 3-methylxanthine (3-MX), 1-methylxanthine (1-MX) and 1,3-dimethyluric acid (1,3-DMU) in human liver microsomes is described. The analytes were extracted from human liver microsomes with methylene chloride/isopropanol and stepwise gradient elution was employed for the resolution of peaks. The limits of quantitation were 15 ng/mL for 3-MX, 20 ng/mL for 1-MX and 20 ng/mL for 1,3-DMU. The calibration range was linear for the three metabolites and the calibration ranges were 15-250 ng/mL for 3-MX, 20-250 ng/mL for 1-MX and 250-4000 ng/mL for 1,3-DMU. The absolute recovery ranged from 63-84% for 3-MX, 65-79% for 1-MX and 77-89% for 1,3-DMU over the calibration curve range. Accuracy for all three metabolites was within +/- 10% and adequate selectivity was demonstrated by the lack of interfering peaks in blank chromatograms. The within-run and interday precision were within 10% RSD for all three metabolites tested at two concentrations. The advantage of this method over previous methods is that the use of quaternary ammonium ion pair reagents in the mobile phase has been obviated. Also, unlike a previous radiometric HPLC method, the need for radiolabelled theophylline has also been eliminated. The method was used to characterize theophylline metabolism in human liver microsomes for immunoinhibition studies and to investigate the interaction of theophylline with selected quinolone antibiotics.