gebhart/patrepeval huggingface dataset:
The Acoustic Reactance of Small Circular Orifices (1949)

A precise experimental study of the reactive component of the complex impedance of small circular orifices has been made for a number of orifices varying in diameter from 2 cm down to 0.357 cm, with diameter/thickness ratios from 4 to 40, over the frequency range from 200 to 1000 c.p.s. The measurement of the impedance is performed with a precision impedance tube. A theoretical correction for the influence of the tube walls is applied by considering the orifice to act as a plane piston and taking into account the influence of all possible higher order modes of the tube in the neighborhood of the orifice. Comparison between calculated and measured values of reactance shows that, as far as this quantity is concerned, the assumption that the orifice acts like a plane piston appears valid for radii equal to or greater than 1 cm for “thin” orifices within the range of variables specified above. For orifices of radii less than 1 cm, however, a modification of the radius is necessary to make the classical theoretical equation for orifice reactance fit the measured data. The observations and analyses reported here are restricted to wave-lengths much greater than the hole diameter and to the low velocity region where reactance is independent of particle velocity.
Multiview multiperspective time multiplexed autostereoscopic display (2008)

The implementation of a time multiplexed display capable of eight simultaneously visible viewing zones will be described. The system employs a high speed digital micromirror device (DMD) to allow for the high framerate essential for flicker free display of multiple viewing zones. A combination of custom graphical processor unit (GPU) programming and a correspondingly optimized field programmable gate array (FPGA) DMD driver allows for real time interactive rendering of scenes. The rendering engine is entirely based on off the shelf with the use of a standard DVI-D interface for data transfer to the DMD interface. A rapidly switched LED light engine is employed to overcome the speed limitations of color wheel light sources, as well as providing a highly saturated color gamut. Selection of viewing zones is achieved by the use of a high-speed shutter interfaced directly to the DMD driver for precise synchronization.
ChemInform Abstract: NEW OXOTECHNETIUM(V) COMPLEXES OF N,N′‐ETHYLENEBIS(ACETYLACETONE IMINE), N,N′‐ETHYLENEBIS(SALICYLIDENEAMINE), AND O‐PHENYLENEBIS(SALICYLIDENEAMINE). X‐RAY STRUCTURES OF THE COMPLEXES OF N,N′‐ETHYLENEBIS(ACETYLACETONE IMINE) AND N,N′‐ETHYLENEBIS(SALICYLIDENEAMINE) (1984)

Abstract Durch direkte Substitutionsreaktion mit den vierzähnigen Schiffschen Basen‐Liganden werden aus [TcOCl4]′ die Komplexe (I) 133 und (II) synthetisiert.
5.8-km 10-Gbps data transmission over a 120-GHz-band wireless link (2010)

We have developed 120-GHz-band wireless equipment that can transmit 10-Gbit/s data signal over a distance of more than 5 km. In order to increase the output power of the120-GHz-band wireless equipment, we used a millimeter-wave amplifier that integrates 0.08-μm-gate-length InGaAs/InP composite-channel high-electron-mobility transistors. The output power of the wireless equipment becomes 16 dBm. The wireless equipment can handle data rates of 1 Mbit/s to 11.1 Gbit/s and transmit 10-Gbit/s-class data signals with and without forward error correction (FEC). We conducted wireless data transmission experiments over a distance of 4.8 km and 5.8 km and succeeded in the error-free data transmission of 10-Gbit/s data with FEC.
Induced Production of Halogenated Epidithiodiketopiperazines by a Marine-Derived <i>Trichoderma</i> cf. <i>brevicompactum</i> with Sodium Halides (2015)

Marine-derived Trichoderma sp. TPU199 (cf. T. brevicompactum) produced gliovirin (1), pretrichodermamide A (2), and trichodermamide A (3) in a freshwater medium. Compounds 1 and 2 are rare epidithiodiketopiperazines possessing an unusual disulfide linkage. In the seawater medium, the strain biosynthesized the 5-chloro-5-deoxy derivatives (4 and 5) of 3 and 2. The production of 5 was proportional to the concentration of seawater (NaCl). Therefore, 5-bromo-5-deoxy (6) and 5-deoxy-5-iodo (7) derivatives were biosynthesized in the freshwater media supplemented with NaBr and NaI, respectively. The structure of a new iodo derivative (7) was elucidated on the basis of its spectroscopic data.
Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry (2015)

Hepatitis C virus (HCV) enters human hepatocytes through a multistep mechanism involving, among other host proteins, the virus receptor CD81. How CD81 governs HCV entry is poorly characterized, and CD81 protein interactions after virus binding remain elusive. We have developed a quantitative proteomics protocol to identify HCV-triggered CD81 interactions and found 26 dynamic binding partners. At least six of these proteins promote HCV infection, as indicated by RNAi. We further characterized serum response factor binding protein 1 (SRFBP1), which is recruited to CD81 during HCV uptake and supports HCV infection in hepatoma cells and primary human hepatocytes. SRFBP1 facilitates host cell penetration by all seven HCV genotypes, but not of vesicular stomatitis virus and human coronavirus. Thus, SRFBP1 is an HCV-specific, pan-genotypic host entry factor. These results demonstrate the use of quantitative proteomics to elucidate pathogen entry and underscore the importance of host protein-protein interactions during HCV invasion.
Virulence of serotype M3 Group A<i>Streptococcus</i>strains in wax worms (<i>Galleria mellonella</i>larvae) (2011)

Group A Streptococcus (GAS) causes human infections that range in severity from pharyngitis ("strep-throat") to necrotizing fasciitis ("flesh-eating disease"). To facilitate investigation of the molecular basis of host-pathogen interactions, infection models capable of rapidly screening for differences in GAS strain virulence are needed. To this end, we developed a Galleria mellonella larvae (wax worm) model of invasive GAS infection and used it to compare the virulence of serotype M3 GAS strains. We found that GAS causes severe tissue damage and kills wax worms in a dose-dependent manner. The virulence of genetically distinct GAS strains was compared by Kaplan-Meier survival analysis and determining 50% lethal doses (LD 50). Host-pathogen interactions were further characterized using quantitative culture, histopathology and TaqMan assays. GAS strains known to be highly pathogenic in mice and monkeys caused significantly lower survival and had significantly lower LD 50s in wax worms than GAS strains associated with attenuated virulence or asymptomatic carriage. Furthermore, isogenic inactivation of proven virulence factors resulted in a significantly increased LD 50 and decreased lesion size compared to the wild-type strain, a finding that also strongly correlates with animal studies. Importantly, survival analysis and LD 50 determination in wax worms supported our hypothesis that a newly emerged GAS subclone that is epidemiologically associated with more human necrotizing fasciitis cases than its progenitor lineage has significantly increased virulence. We conclude that GAS virulence in wax worms strongly correlates with the data obtained in vertebrate models, and thus, the Galleria mellonella larva is a useful host organism to study GAS pathogenesis.
Investigation Of Photosensitizing Properties Of Protoporphyrin Derivatives With Aminoacid Substituents (1987)

A method for attachmet of any aminoacid residue to the protoporphyrin (PP) molecule has been developed leading to synthesis of a new class of protoporhyrin derivatives. Photosensitising properties of the new derivatives have been measured under "in vitro" conditions and compared with those of hematoporphyrin (HP). Dimerization constants of the new photosensitizers in aqueous PBS solutions were also determined.
Reiter's syndrome following epidemic shigellosis. (1982)

To define the epidemiology of post-dysenteric Reiter's syndrome (RS), 1,162 persons were questioned about compatible symptoms soon after 3 separate outbreaks of shigellosis. We diagnosed RS for 3 women of 204 persons ill during an outbreak of Shigella flexneri 1b, for 3 women of 206 ill during an outbreak of S. flexneri 2a, and for none of 85 ill during an outbreak of S. sonnei. We found no RS among 667 persons without diarrhea. Prospective controlled investigations in defined populations documented that RS follows S. flexneri 1b as well as 2a infections in about 1.5% of white adults with dysentery and indicated that women develop post-dysenteric RS as often as men.
Immunohistochemical Analysis of Peripheral T-Cell Lymphoma in Japanese Patients (1989)

The authors immunohistochemically analyzed the phenotype of 40 cases of peripheral T-cell lymphoma, including 12 adult T-cell leukemia/lymphoma (ATL) cases. Molecular genetic analysis of the T-cell receptor beta-chain and immunoglobulin heavy chain genes were also applied to cases of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)-like lymphoma and so-called Lennert's lymphoma. Twenty non-ATL lymphomas expressed a helper/inducer phenotype, whereas only one extranodal case expressed a suppressor/cytotoxic phenotype. Three cases had a CD4-CD8- phenotype, and two cases a CD4+CD8+phenotype. No specific relationship between morphologic characteristics (LSG classification) and phenotype was found among non-ATL lymphomas. Six of eight AILD-like lymphomas had a helper/inducer phenotype. Monoclonality of neoplastic T-cells was demonstrated in six of the seven cases of AILD-like lymphoma by molecular genetic analysis. Two cases of Lennert's lymphoma also showed a helper/inducer phenotype and rearrangement of the T-cell receptor beta-chain gene. Serologically defined ATL cases had a helper/inducer phenotype except in one case that expressed both CD4 and CD8. None of the ATL cases had the CD7 antigen in this study using WT 1 as a CD7 antibody, which is in contrast with the non-ATL lymphomas in which 13 of 25 cases expressed CD7. CD25, strongly detectable in all ATL cases, was negative or weakly expressed in non-ATL lymphomas. These facts suggest that non-ATL and ATL are in the different biologic state, probably resulting from the integration of human T-cell leukemia virus type I (HTLV-I), although both are derived from helper/inducer T-cells.
Benzoxazinone derivatives: new fluorescent probes for two‐color flow cytometry analysis using one excitation wavelength (1989)

A new class of fluorescent dye which upon excitation at 488 nm turns red is shown to be probe-suitable for using in flow cytometry alone or in conjunction with fluorescein derivatives. 7-dimethylamino 3-(p-formylstyryl) 1,4 benzoxazin 2-one is suitable for rendering microorganisms, such as Plasmodium merozoites and cells detectable by flow cytometry, allowing a dual fluorescence analysis when the cells are labelled with suitable fluoresceinylated ligands such as fluorescein labeled neoglycoproteins or antibodies. The synthesis of the new benzoxazinone derivatives is described: p-[beta-(7-dimethylamino 1,4 benzoxazin 2-one 3-yl)-vinyl]-phenylpropenoic acid can be easily activated as a hydroxysuccinimide derivative and linked to amino groups of polypeptides. Hydrophilic polypeptides such as poly-L-lysine or glycosylated polymers combined with this new fluorescent dye are shown to be helpful in analyzing cell surface receptors, in dual fluorescence flow cytometry analysis, using a single excitation wavelength and two sets of compounds labeled with the new benzoxazinone derivative and with fluorescein isothiocyanate, respectively. The new benzoxazinone derivative has a high molar absorbance, a good quantum yield fluorescence when it is bound to hydrophilic polypeptides and its fluorescence intensity is not dependent on pH in the physiological pH range.
Modular treatment units for prehospital care (2010)

In recent years UK government policy has increased the provision of urgent care in the community. As part of this initiative, the ambulance service is gradually changing from an organization designed to convey patients to hospital, to a professional group capable of assessing and delivering appropriate treatment to the patient at scene. This paper explores the technology requirements needed to support new professional roles and draws on examples from ambulance trusts (emergency care practitioners), primary care (out-of-hours general practitioners and minor injuries units) and acute trusts (emergency departments). It describes the iterative process used to develop the design specification for modular treatment units for both vehicle and built environments, using a qualitative exploratory methodological framework. Data were collected with 125 staff and 88 patients over 18 months in five phases using stakeholder workshops (2007 and 2008); portable technology audits; treatment observations in emergency departments and walk-in centres; and design decision groups. The results were thematically coded and triangulated to define the functional design requirements for the modular treatment units. The results are discussed as a technology system for personal kit, assessment packages (and storage for other clinical treatment packages) and a modular clinical workspace.
The Most Unforgettable Character I've Met (1945)

(First Place, Essay Division, 1946, Butler University Literary Contest) The most unforgettable character I've met was my stepfather. In general stepfathers aren't very popular with their stepchildren, but he was an exception in this respect as he was in so many others.
<title>Silver halide fibers for blood analysis using fiber optic evanescent wave spectroscopy and neural network models</title> (1996)

Spectral analysis of human blood serum was carried out by fiberoptic evanescent wave spectroscopy (FEWS) and Fourier transform infra red (FTIR) spectrometer, with a silver- halide fiber as the sensing element. The concentrations of three blood components were predicted simultaneously using neural network (NN) models. In order to overcome the problem of fiber deterioration caused by interaction with serum salts, the fiber was coated with a plastic layer. The coating was tested and found to provide excellent protection to the fiber placed in a 3.5% salt solution. This method may be used for in-situ real time and long-lasting measurements.
[Obstetric dermatoses]. (2014)

The specific dermatoses of pregnancy are rare and consist of pemphigoid gestationis (PG), intrahepatic cholestasis of pregnancy (ICP), polymorphic eruption of pregnancy and atopic eruption of pregnancy. The dermatoses are characterized by pruritus, and they are important to recognize since PG and ICP increase the risk of prematurity, fetal distress and stillbirth. Diagnosis is based on medical history, morphology, blood sample and biopsy. The dermatoses are treated with respectively ursodeoxycholic acid (in case of ICP) and steroids. Breast-feeding is recommended and induction of labour is not normally indicated.
P‐2: Visual Strain Evaluation of Physiological Effect by Using 3D Display (2010)

Abstract We evaluate the influences on visual strain and visually‐induced motion sickness in observing 3D image. Based on the SSQ analysis, it is clear that the correlation between visual strain and physical factors of 3D display is more than 90%.
Changes in the image contrast during recording of holograms in nonlinear media with local response (1979)

It is shown that the zero frequency of the spatial spectrum of an image can be filtered off by transient pumping of the intensity of this frequency to the reference wave and simultaneous amplification of the high-frequency components in the course of recording of a dynamic hologram in a nonlinear medium with local response. Experimental results are reported showing that the contrast of amplitude transparencies can be improved by recording holograms in iron-activated lithium niobate crystals.
Development of 5-Substituted<i>N</i>-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile (2012)

One of the most important functions of the opioid system is the control of pain. Among the three main opioid receptor classes (μ, δ, κ), the μ (MOR) is the main type targeted for pharmacotherapy of pain. Opioid analgesics such as morphine, oxycodone and fentanyl are agonists at the MOR and are the mainstay for the treatment of moderate-to-severe pain. However, adverse effects related to opioid use are severe and often lead to early discontinuation and inadequate analgesia. The development of more effective and safer medications for the management of pain still remains a major direction in pharmaceutical research. Chemical approaches towards the identification of novel MOR analgesics with reduced side effects include structural modifications of 14-alkoxy-N-methylmorphinan-6-ones in key positions that are important for binding, selectivity, potency, and efficacy at opioid receptors. This paper describes a representative strategy to improve the therapeutic usefulness of opioid analgesics from the morphinan class of drugs by targeting position 5. The focus is on chemical and biological studies and structure-activity relationships of this series of ligands. We report on 14-alkoxymorphinan-6-ones having a methyl and benzyl group at position 5 as strong opioid antinociceptive agents with reduced propensity to cause undesired effects compared to morphine although interacting selectively with MORs.
Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart (2018)

Ischemic heart failure is the leading cause of mortality worldwide. An early boost of intracardiac regenerative key mechanisms and angiogenetic niche signaling in cardiac mesenchymal stem cells (MSCs) could improve myocardial infarction (MI) healing. Epicardial erythropoietin (EPO; 300 U kg<sup>-1</sup>) was compared with intraperitoneal and intramyocardial EPO treatments after acute MI in rats (<i>n</i>=156). Real-time PCR and confocal microscopy revealed that epicardial EPO treatment enhanced levels of intracardiac regenerative key indicators (SDF-1, CXCR4, CD34, Bcl-2, cyclin D1, Cdc2 and MMP2), induced transforming growth factor β (TGF-β)/WNT signaling in intramyocardial MSC niches through the direct activation of AKT and upregulation of upstream signals FOS and Fzd7, and augmented intracardiac mesenchymal proliferation 24 h after MI. Cardiac catheterization and tissue analysis showed superior cardiac functions, beneficial remodeling and increased capillary density 6 weeks after MI. Concomitant fluorescence-activated cell sorting, co-cultures with neonatal cardiomyocytes, angiogenesis assays, ELISA, western blotting and RAMAN spectroscopy demonstrated that EPO could promote cardiomyogenic differentiation that was specific of tissue origin and enhance paracrine angiogenetic activity in cardiac CD45<sup>-</sup>CD44<sup>+</sup>DDR2<sup>+</sup> MSCs. Epicardial EPO delivery might be the optimal route for efficient upregulation of regenerative key signals after acute MI. Early EPO-mediated stimulation of mesenchymal proliferation, synergistic angiogenesis with cardiac MSCs and direct induction of TGF-β/WNT signaling in intramyocardial cardiac MSCs could initiate an accelerated healing process that enhances cardiac recovery.
Interleukin-2 receptor antibody (basiliximab) for immunosuppressive induction therapy after liver transplantation: A protocol with early elimination of steroids and reduction of tacrolimus dosage (2004)

A prospective evaluation was performed to study the potential benefits of the use of interleukin-2 receptor antibody (IL-2Rab) in the induction therapy with early elimination of steroid and reduction of tacrolimus dosage in liver transplant recipients among whom 94% had chronic hepatitis B infection. Thirty-one liver transplant recipients who underwent right-lobe live donor (n = 19) or cadaveric (n = 12) liver transplantation received IL-2Rab, basiliximab 20 mg intravenously within 6 hours of graft reperfusion and on postoperative day 4 (IL-2ab group). Two doses of steroid injection were given intraoperatively and on postoperative day 1. Postoperative immunosuppression was maintained with oral tacrolimus and mycophenolate mofetil without the use of steroids. The operative outcomes were compared with those of 49 patients who received standard immunosuppressive regimen consisting of tacrolimus and corticosteroid (steroid group). The overall postoperative morbidity and hospital stay were comparable between the 2 groups. There were significantly lower incidences of postoperative new-onset diabetes (0% vs 28%, P =.011), acute cellular rejection (6% vs 27%, P =.038), and cytomegalovirus (CMV) antigenemia (0% vs 18%, P =.011) in the IL-2Rab group compared with the steroid group. The blood cholesterol level at 6 months after transplantation was significantly lower in the IL-2Rab group (median, 4.0 vs 4.4 mmol/L, P =.007). On follow-up, none of the patients in the IL-2Rab group had hepatitis B viral breakthrough or hepatocellular carcinoma (HCC) recurrence, whereas 1 and 3 patients in the steroid group developed these complications, respectively. In conclusion, treatment of liver transplant recipients with IL-2Rab with early withdrawal of steroids and reduction of tacrolimus dosage is associated with lower incidences of postoperative new-onset diabetes, acute cellular rejection, and CMV antigenemia, as well as a lower serum cholesterol level. Further studies and long-term follow-up are required to document their potential benefits on hepatitis B and HCC recurrences.
NAP (2009)

In this work we present a simple, yet powerful, methodology for application-agnostic diagnostic and remediation of performance hot spots in elastic multi-tiered client/server applications, deployed as collections of black box Virtual Machines (VM). Our novel out-of-band black-box performance management system, Network Analysis for Remediating Performance Bottlenecks (NAP), listens to the TCP/IP traffic on the virtual network interfaces of the VMs comprising an application and analyzes statistical properties of this traffic. From this analysis, which is application independent and transparent to the VMs, NAP identifies performance bottlenecks that might effect application performance and derives remediation decisions that are most likely to alleviate the application performance degradation. We prototyped our solution for the Xen hypervisor and evaluated it using the popular Trade6 benchmark that simulates a typical e-commerce application. Our results show that NAP successfully identifies performance bottlenecks in a complex multi-tier application setting, while incurring negligible performance overhead.
The Response of Resistant and Susceptible Strains of Chickens and Their F1 and F2 Crosses to Subcutaneous Inoculations with Rous Sarcoma Virus (1967)

WORK by Bower et al. (1964, 1965) reported on the response of chorioallantoic membranes of two strains of chicken embryos and their F1- and F2-generation crossbreds to inoculations with Rous sarcoma virus. It was found that the “Giant Jungle Fowl” was resistant while the White Leghorn was susceptible and the F1 cross gave an intermediate response. Dhaliwal (1963) stated that the mechanism of resistance of the chorioallantoic membrane to Rous sarcoma virus was different from that of the embryo proper and the hatched chick or adult chicken. Beard (1958) mentioned that occasional retrogression had been observed in most types of tumors. In light of these observations, the present work was planned to investigate the response of the “Giant Jungle Fowl” and White Leghorn strains, their F1- and F2-generation crossbreds, to subcutaneous inoculations of Rous sarcoma virus in the wing web of five-week-old chickens. This mode of inoculation was chosen because …