gebhart/patrepeval huggingface dataset:
Function of host defence peptide LL-37 in human periodontal disease. (2010)

Objectives: Fibroblasts play a significant role as regulators of the host response in periodontal disease, responding to bacterial stimulation by producing an array of inflammatory cytokines and chemokines. LL-37, a host defence peptide, inhibits LPS-induced cytokine signalling in macrophages, suggesting an immunomodulatory role. The objective was to investigate the interaction between LL-37 and gingival fibroblasts – both its direct regulation of fibroblast activity and its effect on fibroblast response to LPS activation. Methods: Human gingival fibroblasts (HGFs) were incubated for 24 hours in the presence of either P. gingivalis LPS (10µg/ml) or E. coli LPS (10ng/ml) along with LL-37 (0-50 µg/ml). IL-6 and IL-8 production by HGFs in the conditioned medium was determined by ELISA. Western blot was performed to determine the effect of LL-37 on LPS -induced IκBα degradation in HGFs following LPS stimulation over 2 hours. DNA microarray analysis was performed on cell populations incubated for 6 hr in the presence or absence of the peptide. Confirmation of LL-37 effects on specific gene expression was obtained by QPCR. Results: At low concentrations (≤ 5 µg/ml) LL-37 significantly inhibited LPS-induced cytokine production by HGFs. At higher concentrations LL-37 induced IL-8 production independent of LPS. Addition of LL-37 blocked LPS-induced IκBα degradation in HGFs. Microarray analysis revealed that LL-37 (50µg/ml) upregulated a significant number of cytokines and chemokines by > 5 fold. Upregulation of five of these, CXCL1, CXCL2, CXCL3, IL-24 and IL-8 was confirmed by Q-PCR. Conclusion: The host defence peptide LL-37, the only known human cathelicidin, appears to have pleiotrophic effects in innate immunity. At least some of these are mediated through cytokine and chemokine signalling networks. The ability of LL-37 to reduce bacterial LPS-induced cytokine production in gingival fibroblasts, at low concentrations, suggests a potential therapeutic role in the management of periodontal disease.
The unusual reactivity of 9,9'-dianthrylcarbene (1988)

NRC publication: Yes
False path exclusion in delay analysis of RTL structures (2002)

In this paper, we present an accurate delay-estimation algorithm at the register-transfer level. We study three important sources of false paths in register-transfer-level (RTL) structures, i.e., 1) resource binding; 2) interdependent conditions; and 3) datapath-controller path mismatching. The existence and creation of such paths and their effects in delay analysis are discussed. We show that in a RTL datapath structure the accuracy of the delay estimators is affected by the existence of false paths. Specifically, the accuracy drops significantly for structures synthesized from condition-dominated behaviors. We propose a mechanism to efficiently avoid false paths in delay analysis. This is achieved by introducing the propagation delay graph (PDG), whose traversal for delay analysis is equivalent to the traversal of sensitizable paths in the datapath. Comparison with the timing verifier in commercial computer-aided design (CAD) tools, show that estimated delays are within 14% accuracy of those reported by CAD tools.
Fetal Response to Voluntary Maternal Hyperventilation (1982)

Maternal hyperventilation can cause transient reduction in fetal oxygen tension. Fifty women with normal and high-risk pregnancies, between the 32nd and 43rd week, were voluntarily hyperventilated; in 33, fetal heart rate (FHR) acceleration or transient tachycardia were observed (reactive FHR). Of the 33 pregnancies the outcome was good in 30 (91%) as judged by the absence of perinatal death, no fetal distress in labor and no intrauterine growth retardation (IUGR). In 14 patients in whom there was no FHR response to maternal hyperventilation (non-reactive FHR), the outcome of pregnancy was significantly worse; one infant died neonatally, 10 were either chronically (IUGR), or acutely distressed. Only in 3 was the outcome good (21%). The study showed that there is good correlation between a "reactive" FHR and favorable neonatal outcome, and between a "non-reactive" FHR and an unfavorable neonatal outcome.
THE EFFECT OF THE CONSUMPTION OF NPV-INFECTED DEAD FALL ARMYWORM LARVAE ON THE LONGEVITY OF TWO SPECIES OF SCAVENGER BEETLES (1985)

Adults of the scavenger beetles Ateuchus histeroides Weber and Trox suberosus F. (Coleoptera: Scarabaeidae) were fed 4 meals in the laboratory over a 3-wk interval, of either dead fall armyworm larvae killed by nuclear polyhedrosis virus (NPV) or non-infected fall armyworm larvae killed in hot water. The beetles were held without additional food for 87 d and the time to death was compared with that of beetles unfed during the test period. For both species, there were no statistically significant differences between the longevity of beetles consuming virus-infected carcasses and those consuming uninfected carcasses. Consequently, the application of fall armyworm NPV in row crop situations would have little negative effect on populations of these scavenger beetles.
Estradiol Induces Vasoactive Intestinal Peptide and Prolactin Gene Expression in the Rat Anterior Pituitary Independently of Plasma Prolactin Levels (1995)

It is well established that estrogens are potent stimulators of prolactin (PRL) secretion. It has also been demonstrated that estradiol (E2) can increase the expression and the anterior pituitary levels of the vasoactive intestinal peptide (VIP), a peptide which also acts as a potent PRL-releasing factor. It thus remained unknown whether the effects on pituitary VIP were due to E2 itself or to E2-induced hyperprolactinemia (HPRL). In order to test this hypothesis, various plasma PRL levels were induced in rats either with ectopic pituitary grafts, PRL secreting tumours or E2 implants, and VIP mRNA expression in the anterior pituitary was measured by in situ hybridization and Northern blot analyses. Whereas decreases in VIP mRNA can be observed in pituitaries of rats with pure HPRL, a 6-fold increase in VIP mRNA can be seen in E2-treated rats. E2 increased both 1.0 and 1.7 Kb VIP mRNA species. The presence of the graft in E2-treated rats significantly reduced the increase in VIPmRNA observed following E2. The direct stimulation by E2 of VIP mRNA expression was further demonstrated by the fact that statistical analysis of the data indicated that both E2 and graft were acting independently of each other, and that a new selective antiestrogen, RU 58668, almost totally blocked the effect of E2. Moreover, under similar experimental conditions, pituitary PRL mRNA levels were reduced in the graft group and a marked up-regulation was observed similarly in both E2 and in E2 rats bearing ectopic grafts.(ABSTRACT TRUNCATED AT 250 WORDS)
Time Resolved Lidar Fluorosensor For Oil Detection (1987)

A contemporary time and spectral analysis of oil fluorescence is important for the detection of oil spills on the sea. An airborne fluorosensor, able to perform this analysis, has been asked to CISE labs by IRC-Ispra. The main feature of the system is the use of a streak camera and of a tripled Nd-YAG laser with 2 ns laser pulse duration.
FTP TYPE Extension for Internationalized Text (2012)

The traditional FTP protocol includes a TYPE command to specify the
data representation. That command has values for ASCII and EBCDIC
text, plus binary (IMAGE) transmission. As the Internet becomes more
international, there is a growing requirement to be able to transmit
textual data, encoded in Unicode, in a way that is independent of the
coding and line representation forms of particular operating systems.
This memo specifies a new FTP representation TYPE value for Unicode
data.
Histoires de la pédagogie institutionnelle (2019)

Les monographies de la pédagogie institutionnelle racontent généralement des histoires d’élèves. Patrice, Jean-Michel, Daniel, Janot d’Aubervilliers, Sophie d’Herblay, Alice d’ailleurs... Ce sont les titres des six monographies publiées en 1967 par Fernand Oury et Aïda Vasquez dans Vers une pédagogie institutionnelle. Quelles en sont les origines ? Quand ces monographies ont-elles été écrites ? Comment ? Par qui ? Comment ont-elles été diffusées ? Comment ont-elle été reçues ? Ce sont ces questions qui sont examinées dans ce livre. L’auteur mène une enquête historique à la recherche des origines de ces textes entre 1949 et 1967. Il nous invite à le suivre dans différents fonds d’archives et lors de ses rencontres avec des témoins de cette histoire de la naissance de la pédagogie institutionnelle. Revisitant l’histoire de ce courant pédagogique, il montre qu’il a contribué à renouveler l’écriture monographique et a permis de nouvelles avancées dans le courant associant pédagogie et psychanalyse.
Synthesis of β-Lactams from Unsaturated Sugars and Isocyanates (1992)

Cycloaddition of trichloroacetyl isocyanate to glycals proceeds satisfactorily at room temperature to give a mixture of [2+2] and [4+2]cycloadducts. The isocyanate attacks the glycal stereospecifically anti with respect to the C-3 substituent. Glycolic cleavage of the vic-diol present in 2-C:1-N-carbonyl-2-deoxy-glycopyranosylamines with sodium meta-periodate provides useful starting materials for the synthesis of 1-oxabicyclic β-lactams.
Combating Occlusion and Scene Changes for Camera Position Determination (2000)

The determination of camera position via eigenspace methods has been applied recently to robot navigation and visual servoing. Conventional eigenspace methods are not robust to occlusion and scene changes due to their global nature. This paper describes techniques for performing robust camera position determination. Input images are divided into separate local areas, with camera position de-termined through eigenspace analysis for each area individually. The positions of occluded sections are ignored in determining the final camera position. The detection of occluded sections is determined by applying a threshold to the eigenspace reconstruc-tion error of the input images. Experiments were performed determining the translational position of a camera and analyzing the magnitude of the errors caused by occlusion, the ability to detect different size occlusions and the accuracy improvement pro-vided by the subsectioning technique. 1
BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius. (1998)

The bursa of Fabricius is a gut-associated lymphoid organ that is essential for the generation of a diversified B cell repertoire in the chicken. We describe here a novel gene preferentially expressed in bursal B cells. The gene encodes an 85-kDa protein, designated BASH (B cell adaptor containing SH2 domain), that contains N-terminal acidic domains with SH2 domain-binding phosphotyrosine-based motifs, a proline-rich domain, and a C-terminal SH2 domain. BASH shows a substantial sequence similarity to SLP-76, an adaptor protein functioning in TCR-signal transduction. BASH becomes tyrosine-phosphorylated with the B cell Ag receptor (BCR) cross-link or by coexpression with Syk and Lyn and associates with signaling molecules including Syk and a putative chicken Shc homologue. Overexpression of BASH results in suppression of the NF-AT activation induced by BCR-cross-linking. These findings suggest that BASH is involved in BCR-mediated signal transduction and could play a critical role in B cell development in the bursa.
A systematic evaluation of devices for measuring abrasive wear of mill liners (2009)

Inspection of the liner wear in the mill of an ore dressing plant is one of the critical parameters in the context of mill downtime and production performance. The total downtime cost during measurement can be reduced by a significant fraction by using appropriate measurement devices. Due to the different quality dimensions of a measuring device, e.g. the cost, accuracy, reliability and accessibility, it is necessary to select an appropriate device based on the specific needs of the industry. Customer satisfaction is perhaps the most important performance measure for the service quality of the device, and therefore this paper provides an approach to define the customer satisfaction with reference to the mentioned quality dimensions. The main aim of this paper is to determine a unified measure or quality index for the service quality of the measurement device across all the dimensions. Each quality index will then correspond to the total predicted usability of the particular measurement method based on the industry needs. Furthermore, this study also discusses the advantages and disadvantages of existing measurement methods and proposes an indirect measurement method to reduce the downtime during inspection.
In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography (2003)

We present <i>in vivo</i> depth-resolved birefringence measurements of the human retinal nerve fiber layer (RNFL) by use of polarization-sensitive optical coherence tomography (PS-OCT). Because glaucoma causes nerve fiber layer damage, which may cause loss of retinal birefringence, PS-OCT is a potentially useful technique for the early detection of glaucoma. We built a fiber-based PS-OCT setup that produces real-time images of the human retina <i>in vivo</i>, co-registered with video images of the location of PS-OCT scans on the retina. Preliminary measurements of a healthy volunteer showed that the double-pass phase retardation per unit depth of the RNFL varies with location with values in between 0.18 and 0.37°/μm. A trend in the preliminary measurements shows that thicker nerve fiber layer tissue is more birefringent than thin nerve fiber layer tissue.
Towards self-protecting smart metering: investigating requirements for the MAPE loop (2012)

Smart grids are increasingly proliferating all over the world to leverage electricity infrastructures with information technology. Smart metering, particularly Advanced Metering Infrastructure (AMI), is an enabling technology for realizing smart grids by collecting and processing energy consumption logs and managing energy for customers and utility companies. Security is one of the main concerns of smart metering, and potential threats and attacks to this technology have been discussed since the early initiatives. Considering the unbounded and changing nature of security problems, especially in complex and critical cyber-physical systems, smart metering security concerns can not be always addressed at design time. Autonomic self-protection promises to address runtime security concerns in proactive and reactive ways. In this paper, we focus on the customer domain of smart metering, and investigate potential reactive self-protection scenarios by concentrating on requirements. To this aim, we analyze a sample set of published security requirements from the AMISEC forum [1] to derive self-protection requirements. Then we discuss how these requirements can be linked to the MAPE loop [2] in the autonomic computing architecture.
Demographic Variability, Vaccination, and the Spatiotemporal Dynamics of Rotavirus Epidemics (2009)

Historically, annual rotavirus activity in the United States has started in the southwest in late fall and ended in the northeast 3 months later; this trend has diminished in recent years. Traveling waves of infection or local environmental drivers cannot account for these patterns. A transmission model calibrated against epidemiological data shows that spatiotemporal variation in birth rate can explain the timing of rotavirus epidemics. The recent large-scale introduction of rotavirus vaccination provides a natural experiment to further test the impact of susceptible recruitment on disease dynamics. The model predicts a pattern of reduced and lagged epidemics postvaccination, closely matching the observed dynamics. Armed with this validated model, we explore the relative importance of direct and indirect protection, a key issue in determining the worldwide benefits of vaccination.
QMHC interview: Karl Albrecht. Interview by Marie E. Sinioris. (1994)

For over a decade, Karl Albrecht has helped health care and other organizations focus on creating superior value for customers. In his books Service America! and The Only Thing That Matters, he developed a model of organizational improvement called Total Quality Service that is tailored to service organizations. One of the principles underlying this model is that service industries are fundamentally different from manufacturing industries. Thus, the approach to quality improvement in services should not be based on a manufacturing mentality. QMHC interviewed Karl Albrecht to catch up with his latest thinking on value creation, leadership, and innovation in health care and elsewhere.
Heterocyclische β‐Enaminoester, 52. Neue Wege zu kondensierten Pyrimidinen über Iminophosphorane (1990)

Heterocyclic β‐Enamino Esters, 52. — New Approaches to Condensed Pyrimidines via Iminophosphoranes The heterocyclic and carbocyclic 2‐(triphenylphosphoranyl‐ideneamino)‐3‐carboxylates 1a , b , 4a – d , and 8a , b , d react with isocyanates in a novel type of pyrimidine annulation to give heterocondensed 2‐alkoxy‐4‐pyrimidinones 3a – d , 5a – h , furthermore 14‐17 (revised constitutions) as well as 4(3 H )‐quinazolinones 9a – g , 10a , b . The constitution of model compound 3a has been established by X‐ray analysis. — Crossover experiments reveal that partially saturated enamino esters, such as 1a , b , 4a – d , undergo strictly an intra molecular 1,3‐shift of the ester alkoxide; a mechanism accounting for this annulation reaction is discussed. Under these conditions, the anthranilates 8 afford a stabilized carbodiimide to which alcohols or amines add before condensation occurs to 4(3 H )‐quinazolinones 9a – c , 10a , b ; however, with the phenyl esters 8b , d the intra molecular 1,3‐migration of the phenoxide is clearly favoured to afford 9f , g . — Reaction of the iminophosphoranes 19a , b of the 1,4‐dihydropyridines 18a , b with acetylenedicarboxylates results in 1‐addition and Aza‐Wittig annulation to give the pyrido[1,2‐ a ]pyrimidines 21a – c .
Thermal Wave (2016)

This paper presents quantities, terminology, and symbols of terms related to photothermal phenomena and used in photothermal and related spectroscopies. The terms used in the literature to describe photothermal phenomena and methods are reviewed, and a glossary of terms is given. The origins of photothermal phenomena, as well as the relations among various photothermal effects, are summarized. The listed terms cover the terminology in transient grating, transient lens, photoacoustic spectroscopy, photothermal radiometry, calorimetry, interferometry, deflection, reflection, and other related spectroscopies, which use or are related to photothermal effects.
Theoretical foundations of radiation chemistry (1959)

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTTheoretical foundations of radiation chemistryAron Kuppermann Cite this: J. Chem. Educ. 1959, 36, 6, 279Publication Date (Print):June 1, 1959Publication History Received3 August 2009Published online1 June 1959Published inissue 1 June 1959https://doi.org/10.1021/ed036p279RIGHTS & PERMISSIONSArticle Views99Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (6 MB) Get e-Alerts Get e-Alerts
Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice (1998)

Abstract Stat3, a member of STAT, is activated by a variety of cytokines such as IL-6 family of cytokines, granulocyte CSF, epidermal growth factor, and leptin. A recent study with mice genetically deficient in the Stat3 gene has revealed its important role in the early embryogenesis. To assess the function of Stat3 in adult tissues, we disrupted the Stat3 gene specifically in T cells by conditional gene targeting using Cre-loxP system. In Stat3-deficient T cells, IL-6-induced proliferation was severely impaired. IL-6 did not enhance cell cycle progression, but prevented apoptosis of normal T cells. In contrast, IL-6 did not prevent apoptosis of Stat3-deficient T cells. Antiapoptotic protein, Bcl-2, was normally up-regulated in response to IL-6 even in Stat3-deficient T cells. These results demonstrate that Stat3 activation is involved in IL-6-dependent T cell proliferation through prevention of apoptosis independently of Bcl-2.
Femtosecond writing of depressed cladding waveguides in strongly cumulative regime (2015)

We proposed a novel approach for direct femtosecond inscription of waveguides. It consisted in formation of cladding with reduced refractive index in fused silica. Depressed cladding was based on peripheral regions of individually written neighbored tracks, which should be inscribed in strongly cumulative regime. It was shown, that due to shot time interval between femtosecond laser pulses and relatively slow thermal diffusion, the exposed focal region surrounds by significantly wide cladding with reduced refracted index. Based on proposed approach we demonstrated depressed cladding waveguide inscription in fused silica using emission directly from commercially available femtosecond oscillator without correcting optical systems and second harmonic generation. It was shown, that the new approach provides formation of easily adjustable single mode waveguides with desired mode field diameter. Such depressed cladding waveguides exploit both advantages of fused silica material and depressed cladding geometry. We also verified our suggestion by experiment and inscribed depressed cladding waveguides with two different mode field diameters at similar femtosecond pulse characteristics. The obtained structures provided low propagation losses and good coupling with Gaussian mode. The waveguides supported propagation of both polarizations with nearly identical characteristics. Obtained experimental results were in good agreement with numerical simulation.
10-GHz dispersion-managed soliton fiber-optical parametric oscillator using regenerative mode-locking: erratum (2005)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Preetpaul S. Devgan, Jacob Lasri, Renyong Tang, Vladimir S. Grigoryan, William L. Kath, and Prem Kumar, "10-GHz dispersion-managed soliton fiber-optical parametric oscillator using regenerative mode-locking: erratum," Opt. Lett. 30, 1743-1743 (2005) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article