gebhart/patrepeval huggingface dataset:
Targeting mitochondria with novel, differently vectorized linear phosphorylated nitrones: (2020)

The free radicals (FR) occurrence in biological signalling or as pathologies triggers is well-documented and the design of specific scavengers to limit oxidative stress is enthralling. Because FR become inactivated upon addition to nitrones, efforts have focused on developing alpha-phenyl-N-tert-butylnitrone derivatives (PBNs) with promising pre-clinical data. To improve efficacy, a new generation of nitrones derived from 2-(diethoxyphosphoryl)-N-(benzylidene)propan-2-amine-N-oxide (PPNs) incorporating an antioxidant framework, gave rise to multipotent drugs exhibiting EPR-spin-trapping properties. As mitochondrial dysfunction is involved in many disorders, efforts have been concentrated on developing tools (pH probes) or pharmacological agents targeting-mitochondria. A series of mitochondria-targeted PPNs was synthesized based on the improved biocompatibility of P-containing nitrones and the expected benefits of introducing a cationic vector. Spin-adducts EPR-parameters toward biologically-relevant FR were established. Cytotoxicity was determined on cells and mitochondria-permeation assessed in isolated rat organs. New mitochondria-targeting nitrones appeared as lower cytotoxic alternative to the commonly used mito-PBN and were safely applied for investigating the anticancer-mechanism of new drugs impacting mitochondria.
GENETIC AND BIOCHEMICAL STUDIES OF THE NUCLEAR SUPPRESSOR NAM2 EXTRANEOUS ACTIVATION OF A LATENT PLEIOTROPIC MATURASE (1983)

GENETIC AND BIOCHEMICAL STUDIES OF THE NUCLEAR SUPPRESSOR NAM2 EXTRANEOUS ACTIVATION OF A LATENT PLEIOTROPIC MATURASE was published in Nucleo-mitochondrial interactions. Proceedings of a conference held in Schliersee, Germany, July 19–23, 1983 on page 233.
ORTHOSTATIC HYPOTENSION AND INTIMA MEDIA THICKNESS: IS THERE ANY ASSOCIATION? (2011)

Fedorowski, A.; Nilsson, P.; Engström, G.; Hedblad, B.; Melander, O. Author Information
Diode rectification of multiphase synchronous generators for aircraft applications (2011)

Increased electrical loading on aircraft power systems has led to interest in DC electrical networks for aircraft applications. This paper investigates a wound-field synchronous generator and uncontrolled diode rectifier as the DC source and analyses the power quality of the AC and DC sides of the rectifier. The paper gives expressions for voltage and current distortion for a multiphase generator as a function of the number of phases. For a star-connected machine, the power quality on the AC side is shown to deteriorate rapidly as the phase number increases, resulting in increased losses and a higher rating requirement. A delta connection provides better utilisation of the generator; however, at the expense of the fault tolerance. Mathematical models for the multiphase system are developed and the analysis is supported by simulation results; verified through laboratory testing.
TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells (2017)

Our results indicate that the coding MSI phenotype of DNA mismatch repair-deficient CRC cells is maintained in their exosomal DNA. Moreover, we uncovered that a recurrent MSI tumor driver mutation like TGFBR2 can reprogram the protein content of MSI cell-derived exosomes and in turn modulate the cytokine secretion profile of recipient cells. Apart from its diagnostic potential, these TGFBR2-dependent exosomal molecular and proteomic signatures might help to understand the signaling routes used by MSI tumors. Fricke et al. uncovered coding microsatellite instability-associated mutations of colorectal tumor driver genes like TGFBR2 in MSI tumor cellderived exosomes. Depending on the TGFBR2 expression status of their donor cells, shed exosomes show distinct proteomic signatures and promote altered cytokine secretion profiles in recipient cells.
Characterization of the thymic IL-7 niche in vivo (2009)

The thymus represents the "cradle" for T cell development, with thymic stroma providing multiple soluble and membrane cues to developing thymocytes. Although IL-7 is recognized as an essential factor for thymopoiesis, the "environmental niche" of thymic IL-7 activity remains poorly characterized in vivo. Using bacterial artificial chromosome transgenic mice in which YFP is under control of IL-7 promoter, we identify a subset of thymic epithelial cells (TECs) that co-express YFP and high levels of Il7 transcripts (IL-7(hi) cells). IL-7(hi) TECs arise during early fetal development, persist throughout life, and co-express homeostatic chemokines (Ccl19, Ccl25, Cxcl12) and cytokines (Il15) that are critical for normal thymopoiesis. In the adult thymus, IL-7(hi) cells localize to the cortico-medullary junction and display traits of both cortical and medullary TECs. Interestingly, the frequency of IL-7(hi) cells decreases with age, suggesting a mechanism for the age-related thymic involution that is associated with declining IL-7 levels. Our temporal-spatial analysis of IL-7-producing cells in the thymus in vivo suggests that thymic IL-7 levels are dynamically regulated under distinct physiological conditions. This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo.
The Lead-Acid Battery - New Horizons in Power Through the Use of Plastics (1968)

<div class="htmlview paragraph">This paper describes the development of a thin wall polypropylene cased battery. The electrical capability has improved in several areas: watt-hours/pound of battery, watt-hours/cubic inch of battery, terminal voltage over full range of electrical load, engine cranking power, and engine cranking energy.</div>
Pharmacological studies of furo (3,2-b) indole derivatives. I. Analgesic, anti-pyretic and antiinflammatory effects of FI-302, N-(3-piperidino-propyl)-4-methyl-6-trifluoromethyl-furo (3,2-b) indole-2-carboxamide, in experimental animals. (1985)

The analgesic, anti-pyretic and anti-inflammatory effects of FI-302, N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl-furo [3,2-b]indole-2-carboxamide, a newly synthesized tricyclic compound, were investigated in comparison with those of nonsteroidal anti-inflammatory drugs (NSAIDs). FI-302 showed potent analgesic and antipyretic effects in the various models used. FI-302 showed an inhibitory effect on acute inflammatory response such as carrageenin-induced edema, but did not show any effect on chronic inflammatory response such as cotton pellet granuloma. These effects of FI-302 were about 2 to 7 times more potent than those of non-acidic NSAIDs such as mepirizole and tiaramide. Moreover, FI-302 had little or no ulcerogenic activity. From these results, it is conceivable that the spectrum of FI-302's activities is similar to those of non-acidic NSAIDs such as mepirizole and tiaramide. These results suggest that FI-302 is a new non-ulcerogenic anti-inflammatory compound, and should be suitably applicable for clinical purposes.
Ein neuer Aluminium/Nickel/Oxo‐Cluster: [Ni(acac)OAl(O<i>t</i>Bu)<sub>2</sub>]<sub>4</sub> (2003)

Abstract Bis(tert‐butoxi)alan ( t Bu‐O) 2 AlH reagiert mit Nickeldiacetylacetonat bei höheren Temperaturen zum neuartigen Nickel‐Aluminium‐Sauerstoff‐Cluster [Ni(acac)OAl(O t Bu) 2 ] 4 ; neben anderen Produkten wird auch Aluminiumtriacetylacetonat Al(acac) 3 gebildet. Der Metall‐Sauerstoff‐Cluster lässt sich durch Kristallisation isolieren und kann über Röntgenstrukturanalyse charakterisiert werden. Das Molekül [Ni(acac)OAl(O t Bu) 2 ] 4 enthält im Zentrum einen achtgliedrigen Al 4 O 4 ‐Ring, an den acht kantenverknüpfte NiO 2 Al‐Ringe über gemeinsame O‐Al‐O‐Einheiten gebunden sind. Die Punktsymmetrie des Metall‐Sauerstoff‐Clusters beträgt nahezu S 4 . Während die Aluminiumatome verzerrt tetraedrisch von Sauerstoffatomen umgeben sind (mittlerer Abstände Al‐O zwischen 1, 730(6) und 1, 789(6) Å)), befinden sich die Nickelatome in verzerrt quadratisch pyramidalen Sauerstoff‐Koordinationssphären (Ni‐O axial = 1, 938(6) Å, Ni‐O basal = 2, 056(9)Å). Die Nickelatome sind in einem Highspin‐d 8 ‐Zustand (μ eff = 3, 32 B.M.).
The Structures of Ag<sub>55</sub><sup>+</sup>and Ag<sub>55</sub><sup>-</sup>:  Trapped Ion Electron Diffraction and Density Functional Theory (2005)

We report the experimental structure determination of cold, mass selected Ag(55)(+/-) cluster ions using the recently developed technique of trapped ion electron diffraction. By comparison of experimental and theoretical molecular scattering functions and consideration of computed total energies, we show that Ag(55)(+) constitutes an ideal Mackay icosahedron, whereas Ag(55)(-) is a weakly Jahn-Teller distorted icosahedron. Isomers of other structural types, for example, decahedral or close-packed, could be ruled out. The candidate structures were obtained by density functional theory calculations.
Virus-Like Particles as an Immunogenic Platform for Cancer Vaccines (2020)

Virus-like particles (VLP) spontaneously assemble from viral structural proteins. They are naturally biocompatible and non-infectious. VLP can serve as a platform for many potential vaccine epitopes, display them in a dense repeating array, and elicit antibodies against non-immunogenic substances, including tumor-associated self-antigens. Genetic or chemical conjugation facilitates the multivalent display of a homologous or heterologous epitope. Most VLP range in diameter from 25 to 100 nm and, in most cases, drain freely into the lymphatic vessels and induce antibodies with high titers and affinity without the need for additional adjuvants. VLP administration can be performed using different strategies, regimens, and doses to improve the immunogenicity of the antigen they expose on their surface. This article summarizes the features of VLP and presents them as a relevant platform technology to address not only infectious diseases but also chronic diseases and cancer.
Controlling the properties of InGaAs quantum dots by selective-area epitaxy (2005)

Selective growth of InGaAs quantum dots on GaAs is reported. It is demonstrated that selective-area epitaxy can be used for in-plane bandgap energy control of quantum dots. Atomic force microscopy and cathodoluminescence are used for characterization of the selectively grown dots. Our results show that the composition, size, and uniformity of dots are determined by the dimensions of the mask used for patterning the substrate. Properties of dots can be selectively tuned by varying the mask dimensions. A single-step growth of a thin InGaAs quantum well and InGaAs quantum dots on the same wafer is demonstrated. By using a single-step growth, dots luminescing at different wavelengths, in the range 1150–1230nm, in different parts of the same wafer are achieved.
Antidepressants as analgesics: an introduction. (2001)

Although the mechanistic basis of antidepressant action has been actively investigated since their introduction as psychotropic agents, a particular focus on mechanisms involved in analgesia is more recent. The mechanisms involved appear to differ — analgesic properties occur independently of antidepressant actions, with a faster onset of action, in lower doses, and with a differing profile of effective agents.
Role of Apoptosis in the Disappearance of Infiltrated and Proliferated Interstitial Cells After Myocardial Infarction (1998)

Myocardial infarction (MI) progresses from the acute death of myocytes and the infiltration of inflammatory cells into granulation, followed by scars. During the healing process, the myocardial interstitial cell population in the infarcted tissues increases markedly and then decreases. We postulated that apoptosis is responsible for this process. Twenty-four male Japanese white rabbits underwent a 30-minute occlusion of the left coronary artery followed by reperfusion for 2 days, 2 weeks, or 4 weeks (n=8 each). The histological features consisted of dead cardiomyocytes and marked leukocyte infiltration at 2 days after MI and granulation consisting of numerous alpha-smooth muscle actin-positive myofibroblasts, macrophage antigen-positive macrophages, and neovascularization at 2 weeks. At 4 weeks, the cellularity decreased markedly, and scars were evident. Interstitial cells with positive nick end labeling were significantly more frequent at the light microscopic level in the 2-day MI samples (5.3+/-3.6% in the center and 6.9+/-3.3% in the periphery of the infarct region) than in the 2-week (2.5+/-1.0%) and 4-week (0.5+/-0.5%) samples. DNA electrophoresis showed a clear ladder in tissues from the ischemic areas at 2 days after MI but not at 2 and 4 weeks after MI. Ultrastructurally, typical apoptotic figures, including apoptotic bodies and condensed nuclei without ruptured plasma membranes, were detected in leukocytes from all hearts with 2-day MI and in myofibroblasts, endothelial cells, and macrophages from all hearts with 2-week MI. In the electron microscopic in situ nick end labeling, immunogold particles intensely labeled the condensed chromatin of the typical apoptotic nuclei. These particles were also accumulated on nuclei of the interstitial cells showing homogeneous density but not definite condensation as typical apoptotic nuclei, suggesting an early stage of apoptosis. Thus, apoptosis plays an important role in the disappearance of both the infiltrated leukocytes and the proliferated interstitial cells after MI. This finding may have therapeutic implications for postinfarct ventricular remodeling through apoptosis handling during the healing stage of MI.
One quarter million (500×500)pixel arrays of silicon microcavity plasma devices: Luminous efficacy above 6lumens∕watt with Ne/50% Xe mixtures and a green phosphor (2006)

Arrays comprising 250 000 Si microcavity plasma devices, each with an emitting aperture of 50×50μm2 and tapered sidewalls (inverted pyramid cavity), have been fabricated in 100-mm (4″) diam. wafers and operated in the rare gases and Ar∕N2 mixtures with sinusoidal ac or bipolar dc excitation. Having an overall active area of 25cm2 and a 25% filling factor, these 500×500 arrays exhibit the pixel-to-pixel emission uniformity characteristics of arrays at least a factor of 6 smaller, and yet are efficient in generating vacuum ultraviolet (VUV) radiation. Luminous efficacies above 6lm∕W and luminance values approaching 2000cd∕m2 are measured when a 500×500 array, operating with a Ne/50% Xe gas mixture, illuminates a 20-μm-thick film of a commercial green phosphor (Mn:Zn2SiO4). Despite the nonoptimal transmission geometry of the array-phosphor structure, the efficacy and luminance produced by the VUV-driven phosphor for a Ne/50% Xe mixture and a total pressure of 800Torr are measured to be 7.2±0.6lm∕Watt and 525±75cd∕m2, respectively, for a 20-kHz sinusoidal ac voltage of ∼284V rms. Maximizing the luminous efficacy–luminance product lowers the optimal pressure of Ne/50% Xe mixtures to roughly 1atm. The magnitude of the radiant output generated by these arrays, in addition to the rapid rise in emitting efficiency with increased Xe content in Ne/10%–50% Xe mixtures, suggest that this microplasma array structure will be of value for both microdisplay and biomedical applications.
A Decade of Studies on Manganese Neurotoxicity in Non-Human Primates: Novel Findings and Future Directions (2014)

Manganese (Mn) is an essential element required for human health because it serves a cofactor function for a number of enzymes in humans. Despite its physiological function, Mn is a double-edged sword in that increased concentrations of Mn in the brain, above those needed for physiological functions, produce a neurological syndrome with behavioral, psychiatric and motor function deficits that are of great concern for human health. We came to study Mn neurotoxicity in non-human primates at a time when there was a great deal of debate and uncertainty in the scientific literature about the role of Mn in idiopathic Parkinson's disease, and its underlying mechanism of toxicity in dopaminergic neurons. There was emerging evidence from human studies that exposure to excess levels of Mn resulted in neuropsychiatric symptoms and cognitive function deficits. In this chapter, I will describe the beginning of our studies on Mn neurotoxicity in non-human primates, what we have discovered, and the new direction that the research has taken. It is important to emphasize that the studies have been a collective effort from many colleagues and collaborators in many departments and research institutions. Only using this transdisciplinary approach could we have accomplished the science that we are doing today and the important findings that are defining the role of Mn in human health and disease.
Adaptation of the pathobionte adherent-invasive E. coli to gut environnment in the context of Crohn's disease (2019)

International audience
Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate (2007)

Here, we report new insights into how destructive/lethal PDT alters the transcriptome not only at the transcriptional level but also at post-transcriptional level via alternative splicing.
Diverging Antioxidative Responses to IGF-1 in Cultured Human Skin Fibroblasts Versus Vascular Endothelial Cells (2012)

Insulin-like growth factor 1 (IGF-1) stimulates cell proliferation and is crucial for maintenance of somatic tissues. However, this effect is associated with the inhibition of FOXO transcription factors and downregulation of antioxidative enzymes. In this study, we compared the responses of primary dermal fibroblasts and human umbilical vein endothelial cells with IGF-1 treatment. We found that IGF-1 primarily downregulated enzymatic antioxidants in skin fibroblasts. However, human umbilical vein endothelial cells were protected from an IGF-1-mediated decrease in antioxidative capacity. Moreover, IGF-1 also activated endothelial nitric oxide synthase in human umbilical vein endothelial cells. These observations suggest a dichotomous role for IGF-1, which provides for growth and repair needs of the soma, while attenuating the effect of oxidative stress on the vasculature by activating endothelial nitric oxide synthase. This increases the production of nitric oxide, an antiproliferative and, under certain circumstances, an antioxidant agent. Findings could help clarify the role of IGF-1 in aging and longevity of lower organisms, short-lived mammals, and humans.
Uncertain Data Clustering-Based Distance Estimation in Wireless Sensor Networks (2014)

For communication distance estimations in Wireless Sensor Networks (WSNs), the RSSI (Received Signal Strength Indicator) value is usually assumed to have a linear relationship with the logarithm of the communication distance. However, this is not always true in reality because there are always uncertainties in RSSI readings due to obstacles, wireless interferences, etc. In this paper, we specifically propose a novel RSSI-based communication distance estimation method based on the idea of interval data clustering. We first use interval data, combined with statistical information of RSSI values, to interpret the distribution characteristics of RSSI. We then use interval data hard clustering and soft clustering to overcome different levels of RSSI uncertainties, respectively. We have used real RSSI measurements to evaluate our communication distance estimation method in three representative wireless environments. Extensive experimental results show that our communication distance estimation method can effectively achieve promising estimation accuracy with high efficiency when compared to other state-of-art approaches.
Time Domain Simulation of Optical MIMO Channels (2015)

Wydawnictwo SIGMA-NOT wydaje czasopisma fachowe informujące swoich czytelników o najnowszych osiągnięciach naukowych i nowoczesnych rozwiązaniach technicznych w Polsce i na świecie, popularyzuje problemy techniczne oraz poszerza wiedzę i kulturę techniczną.
ChemInform Abstract: ORIENTATION EFFECTS ON CHARGE‐TRANSFER‐INTERACTIONS. PART 10. NEW SYNTHESES OF (3.3)PARACYCLOPHANES. DIASTEREOMERIC DONOR‐ACCEPTOR‐(3.3)PARACYCLOPHANES (1977)

Abstract 1,4‐Bis‐mercaptomethyl‐benzol (I) reagiert mit dem Bis‐bromäthylbenzol (II) zum Cyclisierungsprodukt (IIIa), das nach Oxidation zum Bis‐sulfon (IIIb) beim Erhitzen auf 480‐500°C in (IV) übergeht.
Alkynyliodonium Salts in Organic Synthesis. Preparation of Annelated Dihydropyrroles by Cascade Addition/Bicyclization of Dienyltosylamide Anions with Phenyl(propynyl)iodonium Triflate (1999)

The addition of simple pentadienyltosylamide derivatives to the two-carbon electrophile phenyl(propynyl)iodonium triflate initiates a sequence of transformations that furnishes complex, highly functionalized cyclopentenannelated dihydropyrrole products in moderate yields with complete stereoselection. This sequence demonstrates that diyls resulting from homolytic scission of alkylidene carbene-alkene adducts can be readily accessed under mild experimental conditions and that, in the presence of appropriate pendant functionality, these diyls can productively cyclize. The isomeric isoprene-derived tosylamides follow an abbreviated reaction course and deliver azabicyclo[3.1.0]hexanes via an isomerization that competes with diyl formation.
Crystallinity and Influence of Citric Acid as a Compatibilizer in Low Density Polyethylene/Jackfruit Seed Flour Blends (2015)

The properties of blends made from low density polyethylene (LDPE) with various concentration of jackfruit seeds flour (JSF) with the presence of citric acid (CA) were investigated. The JSF content was varied from 0 to 20 wt%. The JSF were blended with LDPE by using an internal mixer (Brabender) at a temperature of 150°C. The test was carried out by using differential scanning calorimetry (DSC), with heating temperature of 100C/min. The crystallinity had improved with the presence of CA. However, the crystallinity slightly reduced with the increasing JSF content and further increased with the presence of CA.