gebhart/patrepeval huggingface dataset:
Platelets and malignancy Rationale and experimental design for the VA Cooperative Study of RA-233 in the treatment of cancer (1982)

Considerable evidence has accumulated in recent years which implicates blood coagulation reactions in the growth and spread of malignancy. In particular, platelets may accumulate on embolic tumor cells and facilitate their adhesion to the endothelium at distant sites perhaps by enhancing blood coagulation reactions. Alternatively, platelets may promote tumor cell proliferation by contributing a growth-promoting factor or through interactions mediated by prostaglandins. Inhibition of tumor growth and spread by platelet-inhibitory drugs has been demonstrated in several experimental tumor systems. Preliminary data suggest that similar effects may be seen in human malignancy. The purpose of this paper is to review relevant literature which provides the rationale for therapeutic trials of platelet-inhibitory drugs in human malignancy and to describe the experimental design for a trial involving one such drug, RA-233, in a recently established VA Cooperative Study.
Virtual environment in control and programming system for reconfigurable machining robot (2016)

Robotic machining systems play an important role in modern manufacturing. The paper proposes the application of virtual robots for off-line programming. The reconfigurable machining robot, programmed in G-code, which can be directly used by CNC machine tool programmers and operators, is presented. The subject of study are 5- and 6-DOF vertical articulated robots that can be configured to emulate vertical and horizontal 5-axis spindle tilting machine tools. The considered machining systems are supported by equivalent virtual robots in the CAD/CAM environment and control system. Several test workpieces were machined to demonstrate the effectiveness of the proposed architecture.
A Comparison of Time Use on an Acute Rehabilitation Unit: Subjects With and Without a Stroke (2001)

This study describes the time use of subjects on a mixed diagnosis inpatient rehabilitation unit. Twelve subjects were observed during two days: one weekday and one weekend day for 8 hours each observational day. Seven subjects had sustained a stroke (CVA) and 5 subjects had other diagnoses (non-CVA). The observers used the behavioral mapping technique to obtain an objective description of the subject's time use and the admission, discharge, and efficiency scores of the Functional Independence Measure (FIM) to obtain a measure of functional activity level.During the weekday observations, the subjects who had a stroke spent more time inactive, 25.0%, as compared to the subjects who had other diagnoses, 15.0%. In addition, the subjects who had a stroke spent more time alone, 53.6%, while the other subjects spent 38.8% time alone. While both amounts of inactivity and time alone increased during the weekend observation, the pattern remained the same. All FIM measures were lower for the subjects who had a stroke as compared to subjects who had other diagnoses.It appears that those who are recovering from a stroke show a discrepancy in self-directed activity level from those who did not have a stroke, while hospitalized on the same unit.
New antiepileptic drugs. (1996)

No fewer than eight new antiepileptic drugs (AEDs) with diverse mechanisms of action have been introduced into clinical practice in the 1990s. Short monographs on lamotrigine, vigabatrin, gabapentin, oxcarbazepine, felbamate, topiramate and vigabatrin have been prepared for this review. Details are provided of mechanisms of action, clinical pharmacokinetics and adverse drug interactions. Each section concentrates on the efficacy, tolerability and practical use of these drugs. The areas where they have potential for superiority over the established AEDs have been highlighted. Specific indications and dosage schedules have been provided. As many of these AEDs have, as yet, limited licences, an attempt has been made to identify ongoing studies and important omissions. Where possible, the eventual place of the new agent in the pharmacological management of epilepsy has been assessed. A more limited summary has been included of zonisamide which, although licensed in Japan, is still regarded as an investigational drug elsewhere. Short discussions of three of the most promising investigational compounds, namely remacemide, losigamone and levetiracetam, complete the picture.
Interpolation in digital modems. I. Fundamentals (1993)

Timing adjustment in a digital modem must be performed by interpolation if sampling is not synchronized to the data symbols. The author describes the fundamental equation for interpolation, proposes a method for control, and outlines the signal-processing characteristics appropriate to an interpolator. A review of previous results and a tutorial exposition of the subject are given, along with new results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Detectors and Data Analysis Techniques for Wide Field Optical Imaging (1997)

This contribution reviews the current status of optical wide field survey astronomy and the basic techniques that have been developed to capitalize on the large volumes of data generated by modern optical survey instruments. Topics covered include: telescope design constraints on wide field imaging; the properties of CCD detectors and wide field CCD mosaic cameras; preprocessing CCD data and combining independent digitized frames; optimal detection of images and digital image centering and photometry methods. Although the emphasis is geared toward optical imaging problems, most of the techniques reviewed are applicable to any large format two-dimensional astronomical image data.
Evaluation of on-state voltage V<inf>CE(ON)</inf> and threshold voltage V<inf>th</inf> for real-time health monitoring of IGBT power modules (2015)

This paper investigates by experiment and simulation the use of the real-time measurements of on-state voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CE(ON)</sub> and threshold voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> for real-time health monitoring of IGBT power modules. A study of the dependencies of each parameter on temperature, wear-out mechanisms and operating conditions is presented. Online measurement circuits are developed to obtain these two parameters during the normal operation of power converters. Junction temperature estimation for health monitoring is implemented using V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> which is a thermo-sensitive electrical parameter. The data of V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CE(ON)</sub> , V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> and T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">J</sub> are combined in a residual-based health monitoring framework which allows the discrimination between two dominant failure mechanisms of power modules: wire-bond lift-off and solder fatigue.
Motion-compensated residue preprocessing in video coding based on just-noticeable-distortion profile (2005)

We present a motion-compensated residue signal preprocessing scheme in video coding scheme based on just-noticeable-distortion (JND) profile. Human eyes cannot sense any changes below the JND threshold around a pixel due to their underlying spatial/temporal masking properties. An appropriate (even imperfect) JND model can significantly help to improve the performance of video coding algorithms. From the viewpoint of signal compression, smaller variance of signal results in less objective distortion of the reconstructed signal for a given bit rate. In this paper, a new JND estimator for color video is devised in image-domain with the nonlinear additivity model for masking (NAMM) and is incorporated into a motion-compensated residue signal preprocessor for variance reduction toward coding quality enhancement. As the result, both perceptual quality and objective quality are enhanced in coded video at a given bit rate. A solution of adaptively determining the parameter for the residue preprocessor is also proposed. The devised technique can be applied to any standardized video coding scheme based on motion compensated prediction. It provides an extra design option for quality control, besides quantization, in contrast with most of the existing perceptually adaptive schemes which have so far focused on determination of proper quantization steps. As an example for demonstration, the proposed scheme has been implemented in the MPEG-2 TM5 coder, and achieved an average peak signal-to-noise (PSNR) increment of 0.505 dB over the twenty video sequences which have been tested. The perceptual quality improvement has been confirmed by the subjective viewing tests conducted.
Ação bacteriolítica dos fosfatos (Fosfatólise bacteriana) (1954)

1) As bactérias são lisadas pelos fosfatos, cuja atividade lítica varia com o sal de fosfato, os trivalentes sendo mais ativos. 2) A fosfatólise independente da viabilidade da bactéria. 3) A fosfatólise póde interferir nas suspensões com tampões de fosfatos e na preservação de hemoculturas.
Some applications of the transition state method to the calculation of reaction velocities, especially in solution (1935)

The first page of this article is displayed as the abstract.
Antioxidant and Nicotine Degradation Effects of Medicinal Herbs (2003)

Antioxidant activity and nicotine degradation activity (NDA) of 21 medicinal herbs were determined by using a 1,1-diphenol-2-picrylhydrazyl (DPPH) method and a PLC/PRF5 human liver cell line method, respectively, to develop an anti-smoking aid. The highest and lowest antioxidant activities represented by IC_(50) value were 30 μg/mL of Eugenia caryophyllus and 3,270 μg/mL of Panax ginseng C. A. Meyer, respectively. Antioxidant activity of Eugenia caryophyllus was equal to 38.0±1.2 mg VCEAC(vitamin C equivalent antioxidant capacity)/ g herb. The highest and lowest NDA values were 1.81 of Astrgalus membranaceus Bunge and 1.01 of Raphani seed and Lespedeza tomentosa Sieb, respectively. Eleven medicinal herbs with high antioxidant activity and/or NDA were selected to make an herbal tea. The herbal tea had high antioxidant activity (50 μg/mL IC_(50) and 22.4±1.4 mgVCEAC/g) and NDA (1.243). The medicinal herb tea could help smokers quitting smoking by degrading and exhausting nicotine accumulated in body and removing reactive oxygen species.
Multijunction thermal convertor. An accurate d.c./a.c. transfer instrument (1965)

The paper describes the performance and method of construction of a multijunction thermal convertor, which, it is claimed, should enable the r.m.s. values of alternating currents and voltages to be measured to an accuracy of within 1 part in 105, and probably 1 part in 106. The convertor gives a large output voltage and has a negligible d.c. reversal change and a short response time. The effect on its performance of Peltier and Thomson heating, and also the extent to which it integrates, have been considered. Equations have been developed to enable the reliability of the convertor as a d.c./a.c. transfer standard to be determined; the claims made for the accuracy of the convertor are based on the solutions to these equations.
HFTL: hybrid flash translation layer based on hot data identification for flash memory (2009)

For the last years, a number of flash translation layers (FTL) have been proposed for hiding erase-before-write architecture of NAND flash memory. However, although many conventional FTLs efficiently provide the logical to physical address remapping algorithms, they could not escape from the performance degradation when handling the hot data which tends to generate so many overwrites on the same logical address. In this paper, we propose a novel FTL algorithm called Hybrid Flash Translation Layer (HFTL) that adaptively exploits the sector mapping and log block based mapping schemes. To do so, HFTL first separates the hot data from the cold data by using the hot data identifier. And then it dynamically manages the former by using the sector mapping scheme showing an optimal performance for intensive overwrites at the same location, and the latter by using the log block based mapping scheme. By using this adaptive hybrid method, HFTL is always guaranteed to yield good performance for the pattern with the hot data as well as the pattern without it. Through a series of experiments, we show that HFTL yields better performance than conventional FTLs.
Behavioral Treatments in Autism Spectrum Disorder: What Do We Know? (2010)

Although there are a large and growing number of scientifically questionable treatments available for children with autism spectrum disorder (ASD), intervention programs applying the scientific teaching principles of applied behavior analysis (ABA) have been identified as the treatment of choice. The following article provides a selective review of ABA intervention approaches, some of which are designed as comprehensive programs that aim to address all developmental areas of need, whereas others are skills based or directed toward a more circumscribed, specific set of goals. However, both types of approaches have been shown to be effective in improving communication, social skills, and management of problem behavior for children with ASD. Implications of these findings are discussed in relation to critical areas of research that have yet to be fully explored.
Effects of triple‐drug therapy with nitazoxanide, high‐dose ribavirin and peginterferon‐α‐2a in patients with chronic hepatitis <scp>C</scp> (2012)

This three-drug regimen was effective in achieving SVR in patients with HCV genotype 1. No patients relapsed, and the toxicity profile was favorable. Further studies on the role of nitazoxanide in the treatment of chronic HCV are warranted.
Exploiting Low-Dimensional Structure in Astronomical Spectra (2018)

Dimension-reduction techniques can greatly improve statistical inference in astronomy. A standard approach is to use Principal Components Analysis (PCA). In this letter we apply a recently-developed technique, diffusion maps, to astronomical spectra, and develop a robust, eigenmode-based framework for regression and data parameterization. We show how our framework provides a computationally efficient means by which to predict redshifts of galaxies, and thus could inform more expensive redshift estimators such as template cross-correlation. It also provides a natural means by which to identify outliers (e.g., misclassified spectra). We analyze 3846 SDSS spectra and show how our framework yields an approximately 99% percent reduction in dimensionality. Finally, we show that the prediction error of the diffusion map-based regression approach is markedly smaller than that of a similar approach based on PCA, clearly demonstrating the superiority of diffusion maps over PCA and traditional linear data reduction techniques.
Individual and combined activities of clarithromycin and its 14-hydroxy metabolite in a murine model of Haemophilus influenzae infection (1991)

Clarithromycin is metabolised in man mainly to the 14-hydroxy derivative, which is also biologically active. As this metabolite is not produced in rodents, we used a murine model of Haemophilus influenzae pulmonary infection to compare the in-vivo activity of clarithromycin and 14-hydroxy clarithromycin, alone and in combination, and erythromycin. In terms of bacterial killing, clarithromycin's 14-hydroxy metabolite was much more active than clarithromycin and erythromycin at doses of 100 mg/kg. For the combination tests, low doses of 14-hydroxy clarithromycin (12, 16 and 24 mg/kg) were ineffective alone but potentiated the bactericidal activity of clarithromycin (100 mg/kg) (P less than 0.01-0.001). The in-vivo results can be explained by in-vitro and pharmacokinetic data: the MIC and MBC of 14-hydroxy clarithromycin are half those of clarithromycin and erythromycin, while the combination of clarithromycin and its metabolite was synergistic in terms of bacteriostatic and bactericidal activities. Potentially useful levels of 14-hydroxy clarithromycin were found after oral administration of low doses, with a prolonged half-life compared with that of the parent compound. On the basis of these results it appears that the 14-hydroxy metabolite may have an important role to play in the treatment of bronchopulmonary infections in man due to H. influenzae.
Voltage-independent Inhibition of P/Q-type Ca2+Channels in Adrenal Chromaffin Cells via a Neuronal Ca2+Sensor-1-dependent Pathway Involves Src Family Tyrosine Kinase (2001)

In common with many neurons, adrenal chromaffin cells possess distinct voltage-dependent and voltage-independent pathways for Ca(2+) channel regulation. In this study, the voltage-independent pathway was revealed by addition of naloxone and suramin to remove tonic blockade of Ca(2+) currents via opioid and purinergic receptors due to autocrine feedback inhibition. This pathway requires the Ca(2+)-binding protein neuronal calcium sensor-1 (NCS-1). The voltage-dependent pathway was pertussis toxin-sensitive, whereas the voltage-independent pathway was largely pertussis toxin-insensitive. Characterization of the voltage-independent inhibition of Ca(2+) currents revealed that it did not involve protein kinase C-dependent signaling pathways but did require the activity of a Src family tyrosine kinase. Two structurally distinct Src kinase inhibitors, 4-amino-5-(4-methylphenyl)7-(t-butyl)pyrazolo[3,4-d] pyrimidine (PP1) and a Src inhibitory peptide, increased the Ca(2+) currents, and no further increase in Ca(2+) currents was elicited by addition of naloxone and suramin. In addition, the Src-like kinase appeared to act in the same pathway as NCS-1. In contrast, addition of PP1 did not prevent a voltage-dependent facilitation elicited by a strong pre-pulse depolarization indicating that this pathway was independent of Src kinase activity. PPI no longer increased Ca(2+) currents after addition of the P/Q-type channel blocker omega-agatoxin TK. The alpha(1A) subunit of P/Q-type Ca(2+) channels was immunoprecipitated from chromaffin cell extracts and found to be phosphorylated in a PP1-sensitive manner by endogenous kinases in the immunoprecipitate. A high molecular mass (around 220 kDa) form of the alpha(1A) subunit was detected by anti-phosphotyrosine, suggesting a possible target for Src family kinase action. These data demonstrate a voltage-independent mechanism for autocrine inhibition of P/Q-type Ca(2+) channel currents in chromaffin cells that requires Src family kinase activity and suggests that this may be a widely distributed pathway for Ca(2+) channel regulation.
Pathogenesis of sepsis: new concepts and implications for future treatment (2003)

Severe sepsis and septic shock are important causes of death in intensive care units. Although our understanding of the pathogenesis of inflammation and sepsis has improved, until recently this has not translated into clinical benefit. Several new treatment approaches have given encouraging results. Evidence suggests that the way forward is to develop pathogen specific regimens rather than assume that one treatment fits all.

#### Summary points

Bacterial cell walls, endotoxins, and exotoxins are powerful activators of innate and acquired immune responses

Molecules expressed by pathogens interact with Toll-like receptors on immune cells, activating the immune response

Cytokines are important in the pathogenesis of sepsis

Susceptibility to sepsis may be due to inherited or acquired mutations of innate immune genes

Severe sepsis and septic shock are clinical manifestations of a dysregulated immune response to invasive pathogens

Adjunctive therapy with low dose steroids, activated protein C or early supportive care can reduce mortality from severe sepsis and septic shock

Pathogen recognition receptors (such as Toll-like receptors) and mediators of sepsis (such as macrophage migration inhibitory factor) might be novel targets for treatment

We selected articles for this review by searching Medline using the keywords sepsis, therapy, and Toll-like receptors. We concentrated on publications on the pathogenesis of sepsis and treatment of septic shock. As the number of references that could be cited was limited, we have often referenced review articles rather than original publications.

Severe sepsis and septic shock are life threatening complications of infections and the most common cause of death in intensive care units. However, a lack of widely accepted definitions of these complications has made it difficult to obtain accurate estimates of their frequency. A study published by the Centers for Disease Control in the United States indicated that the incidence of septicaemia had increased from 73.6 per 100 000 patients in …
Ligand-Promoted Alkylation of C(sp<sup>3</sup>)–H and C(sp<sup>2</sup>)–H Bonds (2014)

9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))-H and C(sp(2))-H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.
Language in culture (2010)

As increased access to employment and educational opportunities brought dramatic changes to women's lives, sociologists began to look at the effect of women's changing roles on their children and families. Based on empirical investigations and personal experience, the studies included in the volumes of The Sociology of Gender and the Family set of The International Library of Sociology set out to establish patterns and regularities in social behaviour, and to understand the social roles of kinship groups, mothers, wives, children and the elderly.
Solid lipid nanoparticles for ocular drug delivery (2010)

Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable of increasing ocular bioavailability and decreasing both local and systemic cytotoxicity. Nanotechnology is expected to revolutionize ocular drug delivery. Many nano-structured systems have been employed for ocular drug delivery and yielded some promising results. Solid lipid nanoparticles (SLNs) have been looked at as a potential drug carrier system since the 1990s. SLNs do not show biotoxicity as they are prepared from physiological lipids. SLNs are especially useful in ocular drug delivery as they can enhance the corneal absorption of drugs and improve the ocular bioavailability of both hydrophilic and lipophilic drugs. SLNs have another advantage of allowing autoclave sterilization, a necessary step towards formulation of ocular preparations. This review outlines in detail the various production, characterization, sterilization, and stabilization techniques for SLNs. In-vitro and in-vivo methods to study the drug release profile of SLNs have been explained. Special attention has been given to the nature of lipids and surfactants commonly used for SLN production. A summary of previous studies involving the use of SLNs in ocular drug delivery is provided, along with a critical evaluation of SLNs as a potential ocular delivery system.