gebhart/patrepeval huggingface dataset:
Micrococcus luteus correndonucleases. II. Mechanism of action of two endonucleases specific for DNA containing pyrimidine dimers. (1977)

Py pyrimidine dimers Py correndonucleases I and II from Micrococcus luteus act exclusively on thymine-thymine, cytosine-cytosine, and thymine-cytosine cyclobutyl dimers in DNA, catalyzing incision 5' to the damage and generating 3'-hydroxyl and 5'-phosphoryl termini. Both enzymes initiate excision of pyrimidine dimers in vitro by correxonucleases and DNA polymerase I. The respective incised DNAs, however, differ in their ability to act as substrate for phage T4 polynucleotide ligase or bacterial alkaline phosphatase, suggesting that each endonuclease is specific for a conformationally unique site. The possibility that their respective action generates termini which represent different degrees of single strandedness is suggested by the unequal protection by Escherichia coli binding protein from the hydrolytic action of exonuclease VII.
Sulfur (Or Selenium)-Mediated Synthesis of Methanoanthracene Derivatives. The First Synthesis of a Seleno-Cyanohydrin (1994)

Abstract A synthesis of thio- and seleno-substituted 9,10-dihydro-9,10-methanoanthracene derivatives is reported. They are obtained by Wittig rearrangement from 11-thia and 11-selena-9,10-dihydro-9,10-ethanoanthracene derivatives. This rearrangement is applied to the first synthesis of a seleno-cyanohydrin (R1R2C(SeH)CN). Key Words: 9,10-dihydro-9,10-methanoanthraceneWittig rearrangementseleno-cyanohydrineDiels-Alder adductsthioaldehydesanthracene derivatives.
Flow and anchoring effects on nematic fluctuations in confined geometry (2013)

Light scattering observation of nematic director fluctuations in confined geometries can be used to obtain interaction parameters of liquid crystals with surfaces. We present the basics of the method and some examples of the results in planar and cylindrical geometries. These results were obtained after neglecting the coupling of the director motion to flow. We give analytical and numerical results of flow effects on director fluctuations in a slab. The backflow contribution to the effective viscosity is strongly suppressed so that the results for the anchoring energy remain valid. Modal dispersion relations show an interesting behaviour of avoiding crossings.
Secure-CITI Critical Information-Technology Infrastructure (2006)

The Secure and robust Critical Information-Technology Infrastructure (S-CITI for short) project aims at providing support to Emergency Managers (EMs) that are faced with management of resources and with decisions before, during, and after emergencies or disasters. Our approach consists of using new and existing sensors to gather data from the field, processing this data to detect and predict emergency/disaster situations, and disseminating this data among the appropriate organizational units. The data flow will be done in a reliable and secure manner and EMs will coordinate actions in a Virtual Coordination Center (VCC), which need not be in a fixed (and thus vulnerable) physical location. The EMs are responsible for indicating what type of data is more valuable, so that S-CITI can display that information appropriately.
Experimental antitumor activity and toxicity of a new chemotherapeutic agent, BBM 928A. (1983)

The experimental antitumor activity and toxicity of a new antibiotic, BBM 928A (Luzopeptin A), was evaluated in mice. When administered as a suspension in 0.9% NaCl solution, the compound demonstrated good activity [median survival time of dying mice in a drug-treated group divided by the median survival time of 0.9% NaCl solution-treated mice in a tumor control group, (T/C) >150%] against i.p. B16 melanoma (B16) and i.p. P388 leukemia (P388) and weak activity (T/C of 125 to 150%) versus i.v. P388, i.p. L1210 leukemia (L1210), Lewis lung (LL), and Madison 109 lung (M109) carcinomas. In terms of tumor cell kill, BBM 928A induced net reductions in the body burdens of L1210 and P388 leukemias following single-drug injections but usually failed to yield net reductions following multiple-injection therapies despite achieving T/C >125%. Similarly, mice receiving i.p. implants of LL or M109 or i.v. implants of P388 did not generally achieve a net reduction in tumor burden following treatment with BBM 928A despite associated median increases in life span in excess of 25%, but multiple-injection therapies with BBM 928A against i.p. B16 did result in consistent net reductions in tumor levels. The 0.9% NaCl solution-suspended drug was inactive against i.p. Colon 26, s.c. M109, and s.c. B16. Compared to echinomycin, which it resembles in structure, BBM 928A performed very similarly against various murine tumors. For example, against i.p. B16, BBM 928A displayed superiority (average net cell kill advantage of 3.7 log10), but it was comparable against i.p. L1210, P388, LL, and Colon 26 carcinomas, and slightly inferior in the i.p. M109 model. A soluble formulation of BBM 928A was found to be equivalent in activity to the suspension against i.p. P388 and B16 and was slightly active (T/C of 151% or 1.4 log10 net cell kill) versus s.c. B16, whereas the suspension was inactive. In toxicity studies, the soluble formulation, a 0.1-mg/kg dose of which could kill 50% of the treated animals, did not cause leukopenia, nephrotoxicity, or hepatotoxicity as indicated by the lack of an effect upon WBC, blood urea nitrogen levels, and serum glutamic-pyruvic transaminase levels, respectively. Although there was no leukopenia, there were both a dose-related neutrophilia and lymphopenia. Because of its antitumor activity, novel structure, high potency (effective at µg/kg dose levels), strong binding affinity to DNA, and apparent lack of certain organ toxicities, further development of this compound or its analogs is being considered.
Characteristics of an Electrodynamic Wheel Using a 2-D Steady-State Model (2007)

The mechanical rotation of a radially positioned permanent-magnet Halbach array above a conducting, nonmagnetic track induces eddy currents in the track that can inductively create suspension and propulsion forces simultaneously. The parameters that affect the performance of this electrodynamic wheel are studied using a 2-D steady-state finite-element method. Tradeoffs between the lift and thrust force performance are investigated and methods to improve the thrust efficiency are proposed.
Efficient ruthenium-catalysed oxidative cleavage of methyl oleate with hydrogen peroxide as oxidant (2012)

The oxidative cleavage of alkenes leads to the formation of carboxylic acids. One of the few technical processes using this reaction is the production of azelaic acid via the ozonolysis of oleic acid. Because of the need for stoichiometric amounts of the expensive oxidant ozone, together with safety hazards, there is still a requirement for a catalytic process using a cheap and environmentally friendly oxidant. In the present work, the oxidative cleavage of methyl oleate by hydrogen peroxide was catalysed by an easily available ruthenium precursor with dipicolinic acid as ligand. The systematic optimisation of the reaction led to the formation of azelaic acid monomethyl ester in high yields amounting to 86%. The investigation of the reaction pathway showed that the reaction proceeds via a tandem reaction of epoxidation and hydrolysis of the epoxide and oxidative cleavage of the vic-diol.
Babesia Canis Canis, Babesia Canis Vogeli, Babesia Canis Rossi: Differentiation of the Three Subspecies By A Restriction Fragment Length Polymorphism Analysis On Amplified Small Subunit Ribosomal Rna Genes (1999)

The parasites Babesia canis and Babesia gibsoni (phylum Apicomplexa) are responsible for canine babesiosis throughout the world. Babesia canis was previously described as a group of three biologically different subspecies, namely B. canis canis, B. canis vogeli, and B. canis rossi. We report partial sequences of small subunit ribosomal RNA gene (ssu-rDNA) of each subspecies amplified in vitro with primers derived from a semi-conserved region of the ssu-rDNA genes in other Babesia species. The polymerase chain reaction combined with a restriction fragment length polymorphism analysis, using HinfI and TaqI restriction enzymes, confirmed the separation of B. canis into three subspecies. These sequences were compared with previously published sequences of other Babesia species. A phylogenetic approach showed that the three subspecies of B. canis belong to the clade of Babesia species sensu stricto where B. canis canis clusters with B. canis rossi whereas B. canis vogeli might form a monophyletic group with the cluster B. divergens and B. odocoilei. Our results show that the three subspecies of B. canis can readily be differentiated at the molecular level and suggest that they might be considered as true species.
Cobalt Contamination in Silicon (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Multiple bonding in perfluorodiphosphene (FPPF) and perfluorodiphosphinylidene (PPF2) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple bonding in perfluorodiphosphene (FPPF) and perfluorodiphosphinylidene (PPF2)Suqian Jin, Brenda Thies Colegrove, and Henry F. Schaefer IIICite this: Inorg. Chem. 1991, 30, 15, 2969–2977Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ic00015a006https://doi.org/10.1021/ic00015a006research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Low Temperature-Cationic Polymerization of Alkyl Vinyl Ethers and the Properties of Polymers Obtained (1959)

メチルビニルエーテルの低温カチオン重合では, 重合の活性化溶媒とされていたハロゲン化炭化水素以外に, ポリマーの良溶媒であるトルエル中で重合を行なっても高収率で結晶性ポリマーが得られることがわかった、それゆえ活性化という意味はポリマーが触媒をおおうことによって重合の進行を妨げないようにすることに1つの意味があることが明らかとなった。またメチルビニルエーテルはn-ヘキサンークロロホルムまたはn-ヘキサンートルエン混合溶媒中では-78℃の による重合において均一な系でも不均一な系と全く同様に高収率でisotacticポリマーが得られ, X線図の解析および比重の測定からは, これら反応系の外観上の均一または不均一による生成ポリマーの性質の差異は認められなかった。
Compositional dependence of the Raman frequencies and line shapes of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cd</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mi mathvariant="normal">−</mml:mi><mml:mi mathvariant="normal">x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Zn</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>Te determined with films grown by molecular-beam epitaxy (1986)

Raman scattering measurements are used to investigate the lattice-dynamic properties of ${\mathrm{Cd}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{Zn}}_{\mathrm{x}}$Te. The samples were thin films grown by molecular-beam epitaxy on GaAs substrates. The first-order Raman spectra for the ternary samples show two sets of longitudinal- and transverse-optical (LO,TO) modes, which arise from CdTe- and ZnTe-like vibrations. The compositional dependence of the lattice frequencies is that of a typical two-mode system. The mode oscillator strengths were evaluated from the measured frequencies. The line shapes of the LO Raman bands display asymmetrical broadenings which are observed to increase with decreasing LO-TO splitting. The LO bands were fitted with the predicted line shapes of the discrete-continuum interaction and the spatial-correlation models. The Fano line-shape of the discrete-continuum interaction model allows good fittings of both sets of LO Raman bands. The spatial-correlation model does not reproduce the line shapes of the ZnTe-like LO modes for x\ensuremath{\simeq}0.5.
Complications in the Approach to Acoustic Tumor Surgery (1986)

Earlier diagnosis and cooperation with allied specialists in neurosurgery have lessened complications of acoustic tumor surgery. To date, complications cannot always be prevented. The controversy over which approach is best for acoustic tumor extirpation still continues. While teams must answer this question themselves, our experience favors the transtemporal approach. Of the potential disabilities from this operation, facial paralysis or its sequelae remain the most frequent. The transtemporal approach gives a more accurate anatomical definition of the facial nerve. Efforts to preserve hearing (especially with tumors 2 cm or larger), when matched with the potential sequelae of facial paralysis, may prove futile.
Sound production of vortex–nozzle interactions (2001)

The factors which affect the sound production of a vortex as it passes through a nozzle are investigated at both low and high Mach numbers using time-accurate inviscid-flow computations. Vortex circulation, initial position, and mean-flow Mach number are shown to be the primary factors which influence the amplitude and phase of the sound produced. Nozzle geometry and distribution of vorticity are also shown to play significant roles in determining the detailed form of the signal. Additionally, it is shown that solution bifurcations are possible at sufficiently large values of vortex circulation. Comparisons are made between sound signals computed directly using a numerical method for the Euler equations and predictions obtained using a compressible vortex-sound analogy coupled with a compact-source assumption for the computation of vorticity dynamics. The results confirm that the latter approach is accurate for a range of problems with low mean-flow Mach numbers. At higher Mach numbers, however, the non-compactness of the source becomes apparent, resulting in significant changes to the character of the signal which cannot be predicted using the analogy-based approach. Implications for the construction of simplified models of vortex sound in solid-rocket nozzles are discussed.
MULTISCALE DYNAMICS OF SOLAR MAGNETIC STRUCTURES (2012)

Multiscale topological complexity of solar magnetic field is among the primary factors controlling energy release in the corona, including associated processes in the photospheric and chromospheric boundaries. We present a new approach for analyzing multiscale behavior of the photospheric magnetic flux underlying this dynamics as depicted by a sequence of high-resolution solar magnetograms. The approach involves two basic processing steps: (1) identification of timing and location of magnetic flux origin and demise events (as defined by DeForest et al., 2007) by tracking spatiotemporal evolution of unipolar and bipolar photospheric regions, and (2) analysis of collective behavior of the detected magnetic events using a generalized version of Grassberger - Procaccia correlation integral algorithm. The scale-free nature of the developed algorithms makes it possible to characterize the dynamics of the photospheric network across a wide range of distances and relaxation times. Three types of photospheric conditions are considered to test the method: a quiet photosphere, a solar active region (NOAA 10365) in a quiescent non-flaring state, and the same active region during a period of M-class flares. The results obtained show (1) the presence of a topologically complex asymmetrically fragmented magnetic network in the quiet photosphere driven by meso- and supergranulation, (2) the formation of non-potential magnetic structures with complex polarity separation lines inside the active region, and (3) statistical signatures of canceling bipolar magnetic structures coinciding with flaring activity in the active region. Each of these effects can represent an unstable magnetic configuration acting as an energy source for coronal dissipation and heating.
Urethral metastasis from a sigmoid colon carcinoma: a quite rare case report and review of the literature (2014)

Urethral metastasis from colorectal cancer is a very rare occurrence. However, in the presence of urinary symptoms, the possibility of the urethral metastasis should be considered.
Inhibitory Effect of Methyl 2-(4′-Methoxy-4′-oxobutanamide) Benzoate from Jerusalem Artichoke (<i>Helianthus tuberosus</i>) on the Inflammatory Paracrine Loop between Macrophages and Adipocytes (2016)

The interaction between macrophages and adipocytes is known to aggravate inflammation of the adipose tissue, leading to decreased insulin sensitivity. Hence, attenuation of the inflammatory paracrine loop between macrophages and adipocytes is deemed essential to ameliorate insulin resistance and diabetes mellitus type 2. Methyl 2-(4'-methoxy-4'-oxobutanamide) benzoate (compound 1), a newly isolated compound from Jerusalem srtichoke (JA), has not been biologically characterized yet. Here, we investigated whether JA-derived compound 1 attenuates the inflammatory cycle between RAW 264.7 macrophages and 3T3-L1 adipocytes. Compound 1 suppressed the inflammatory response of RAW 264.7 cells to lipopolysaccharide through decreased secretion of IL-1β, IL-6, and TNF-α. Moreover, the mRNA expression of TNF-α, IL-6, IL-1β, MCP-1, and Rantes and MAPK pathway activation in 3T3-L1 adipocytes, incubated in macrophage-conditioned media, were inhibited. These findings suggest an anti-inflammatory effect of a newly extracted compound against adipose tissue inflammation and insulin resistance.
Speed-changing induction motors. Further developments in pole-amplitude modulation (1960)

An earlier paper has described the basic steps which led to a practical form of 8/10-pole induction motor, of good performance, having only one stator winding. The principle on which this speed-changing motor was based has been given the name of ‘pole-amplitude modulation’. Since the publication of the original account of it, the principle has been further developed, and a number of improvements in the method have been devised and tested in practice on several new forms of 8/10-pole motor. This paper discusses the theory and tests on these new machines, which are of interest both in themselves and for the further light which they throw on the principles of pole-amplitude modulation. The tests were completely successful, and this type of machine is now in the repertory of several manufacturers as an established industrial product.
Building Trustworthy Intrusion Detection through VM Introspection (2007)

Psyco-Virt is a high assurance intrusion detection tool that merges host and network intrusion detection technologies with virtual machine introspection. Psyco-Virt architecture includes a cluster of virtual machines, the monitored VMs, which run the OS and applications of interest, and a further VM, the introspection one. Several agents distributed across the monitored VMs execute network and host IDS tools to discover attempted intrusions/attacks on the monitored VMs. The introspection VM makes the detection tools trustworthy by running an introspector and a director to discover any attempt to maliciously modify the kernel, the agents and the IDSes hosted on a monitored VM. On each monitored VM a collector gathers the alerts generated by the agents and forwards them to the director through a control network dedicated to data exchange among the agents and the introspection VM. The director on the introspection VM filters all the alerts and delegates the execution of a proper action to a notifier whenever an intrusion or an attempt to modify the IDSes is detected. In such cases, a monitored VM can either be stopped or frozen and its current state saved in a file for a later, deeper inspection. After describing Psyco-Virt, we discuss some examples of agents and functions using introspection and present preliminary results and performance figures of a first prototype.
Re: Facial Fracture Approaches with Landmark Ratios to Predict the Location of the Infraorbital and Supraorbital Nerves: An Anatomic Study. (2003)

Pediatric Surgical Research Laboratory Department of Surgery Stanford University School of Medicine Stanford, CA
Glycoproteins associated with nuclei of cells before and after transformation by a ribonucleic acid virus (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlycoproteins associated with nuclei of cells before and after transformation by a ribonucleic acid virusAlbert A. Keshgegian and Mary Catherine GlickCite this: Biochemistry 1973, 12, 6, 1221–1226Publication Date (Print):March 1, 1973Publication History Published online1 May 2002Published inissue 1 March 1973https://pubs.acs.org/doi/10.1021/bi00730a032https://doi.org/10.1021/bi00730a032research-articleACS PublicationsRequest reuse permissionsArticle Views15Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Delivering nanoparticles and molecules to the same spot with a superhydrophobic bulls-eye for surface-enhanced Raman scattering (2014)

We present a superhydrophobic silicon bulls-eye. Water droplets remain centered as they dry, enabling delivery of nanoparticles or molecules to the center. SERS spectra of molecules (R6G) at very low concentrations (10−15 M) are demonstrated.