gebhart/patrepeval huggingface dataset:
Stephens, Samuel, 1803-1855 : Letters and journals, at Nelson (1841)

Journals kept by Stephens which include a biographical sketch by his nephew, J Edmund Clark (ppi-ii of v1, 1935), a note to an extract of 1842 (v3, 1936), and a letter to him from Robert Pattie (1935) re the excerpts (pp846-850, v3), letters from Stephens and Sarah Stephens to his mother and sisters, Anne and Ellen and extracts from his journals. Stephens describes his daily life as a surveyor and settler, events in New Zealand, people he met and other aspects of his working and private life. Each volume has a list of contents and v3 has an index. The pages are numbered chronologically through the three volumes. 
Source of title - Supplied 
Quantity: 3 volume(s). 0.05 Linear Metres. 
Physical Description: Typescript (850 leaves, 35 leaves)
DNA Binding and Uptake by Nuclei Isolated from Plant Protoplasts (1978)

Binding and uptake of exogenous DNA by nuclei isolated from Glycine max L. Merr were studied using (3)H-labeled single-stranded DNA of bacteriophage fd. A comparison of single-stranded with double-stranded DNA for binding and uptake by nuclei was also made.Isolated nuclei were incubated with (3)H-labeled single-stranded bacteriophage fd DNA. Poly-l-lysine or DEAE-dextran at 0.1 and 1 mug/ml stimulated DNA binding. On the other hand, poly-l-lysine at 1 and 5 mug/ml increased DNA uptake but DEAE-dextran did not. Ten to 20 mm Ca and Mg ions were required for DNA uptake. EDTA (1-20 mm) did not differ from the control or the low levels of Ca or Mg ions. These observations on single-stranded fd DNA differed from those obtained with double-stranded DNA of Salmonella typhimurium. Kinetics of single-stranded DNA binding and uptake also deviated from that of double-stranded DNA.Analyses of nuclei-bound DNA by sucrose density gradient and CsCI density gradient centrifugation revealed extensive DNA degradation during a 45-minute incubation period. Poly-l-lysine protected against rapid degradation of bound DNA. DEAE-dextran enhanced DNA binding, but bound DNA was cleaved into much smaller polymers than those detected in control experiments or in the presence of poly-l-lysine. Sucrose density gradient and CsCI density gradient centrifugation analyses on DNA taken up by nuclei also showed extensive DNA degradation. Poly-l-lysine slightly inhibited DNA degradation, but DEAE-dextran appeared to enhance degradation of incorporated DNA. Moreover, nonbound DNA in the incubation medium was completely degraded within a 20-minute incubation period.
EVIDENCE FOR A ROLE OF CYCLIC AMP IN NEUROMUSCULAR TRANSMISSION (1969)

Experiments were undertaken to determine if the effects of epinephrine in promoting neuromuscular transmission were mediated by adenosine 3':5'-cyclic phosphate (cyclic AMP). Dibutyryl cyclic AMP and the methyl xanthines, theophylline and caffeine (which inhibit cyclic AMP hydrolysis), were found to increase the amplitude of the end plate potential in the isolated rat diaphragm. Like epinephrine (which is known to promote cyclic AMP synthesis), these agents appear to facilitate the release of acetylcholine from the motor neuron. This interpretation is supported by the observation that theophylline and dibutyryl cyclic AMP markedly increased the frequency but not the amplitude of the spontaneous miniature end plate potentials. In addition, these drugs increased the number of transmitter packets released in response to nerve stimulation. These results are consistent with the view that cyclic AMP plays a role in the release of acetylcholine and in the "defatiguing effect" of epinephrine.
Komunální banka (Ano či ne) (2008)

Cílem bakalářské práce je provést průzkum bankovního trhu a zjistit, kolik bankovních institucí zaměřuje své služby na komunální sféru a dojít k závěru, zda-li by nebylo vhodné založit banku, která by těmito službami uspokojila potřeby komunální sféry. U vybraných bankovních institucí, je provedena vzájemná komparace vybraných bankovních služeb a je zhodnocen jejich přístup ke klientele.
Tips and Tricks for Clinical Graphs using ODS Graphics (2011)

Did you know that you can create an adverse event graph using a vector plot? Or, that you can label dosage levels for a medications plot using a scatter plot? How do you place a reference line between two values on a category axis? Statistical graphics (SG) procedures and the graph template language (GTL) provide you myriad ways to mix and match statements to create graphs. What you can achieve is based on creative usage of the statements. This presentation includes tips and tricks you can use in SG procedures and GTL programs to build your graphs. We use examples from clinical trials and health and life sciences domains to illustrate the techniques using real- world graphs like LFT panels, patient profiles, adverse event plots, and more. Most examples use the second maintenance release of SAS® 9.2, but this presentation also includes a sneak preview of some powerful new features to be released with SAS® 9.3.
Liouville's Theorem and Phase-Space Cooling (1993)

A discussion is presented of Liouville's theorem and its consequences for conservative dynamical systems.A formal proof of Liouville's theorem is given.The Boltzmann equation is derived, and the collisionless Boltzmann equation is shown to be rigorously true for a continuous medium.The Fokker-Planck equation is derived.Discussion is given as to when the various equations are applicable and, in particular, under what circumstances phase space cooling may occur.
Coronary bifurcation stenoses: The kissing balloon probe technique via a single guiding catheter (1989)

A new technique employing two balloon probes via a single (large-lumen) guiding catheter is described. Examples involving the left anterior descending, diagonal, left main (protected), left circumflex-obtuse marginal, and atrioventricular branches and the right coronary artery-posterior descending and posterolateral branches are described and illustrated. This new technology (balloon probes and large-lumen guiding catheter) permits an effective and simplified alternative to the use of the single-guide/two-wire and double-guide/two-dilatation catheter-wire approaches in selected cases in which significant branch vessels (vis-a-vis myocardial regional blood supply) are at risk.
SclR, a Basic Helix-Loop-Helix Transcription Factor, Regulates Hyphal Morphology and Promotes Sclerotial Formation in Aspergillus oryzae (2011)

Most known basic-region helix-loop-helix (bHLH) proteins belong to a superfamily of transcription factors often involved in the control of growth and differentiation. Therefore, inappropriate expression of genes encoding bHLH proteins is frequently associated with developmental dysfunction. In our previously reported study, a novel bHLH protein-encoding gene (AO090011000215) of Aspergillus oryzae was identified. The gene-disrupted strain was found to produce dense conidia, but sparse sclerotia, relative to the parent strain. Here, to further analyze its function, we generated an overexpressing strain using the A. oryzae amyB gene promoter. Genetic overexpression led to a large number of initial hyphal aggregations and then the formation of mature sclerotia; it was therefore designated sclR (sclerotium regulator). At the same time, the sclR-overexpressing strain also displayed both delayed and decreased conidiation. Scanning electron microscopy indicated that the aerial hyphae of the sclR-overexpressing strain were extremely branched and intertwined with each other. In the generation of the SclR-enhanced green fluorescent protein (EGFP) expression strain, the SclR-EGFP protein fusion was conditionally detected in the nuclei. In addition, the loss of sclR function led to rapid protein degradation and cell lysis in dextrin-polypeptone-yeast extract liquid medium. Taken together, these observations indicate that SclR plays an important role in hyphal morphology, asexual conidiospore formation, and the promotion of sclerotial production, even retaining normal cell function, at least in submerged liquid culture.
Serum Melatonin after a Single Aqueous Subcutaneous Injection in Syrian Hamsters (1986)

A single injection of 25 micrograms melatonin was given subcutaneously in 0.1 ml saline either at 3 h into the light phase (morning) in female Syrian hamsters or at 1 h before the beginning of the dark phase (evening) in males (L/D 14/10 h). In both cases, the maximal mean serum values seen at 20 min after injection (50 ng/ml) were more than 1,000 times the normal nocturnal melatonin concentration. By 1 h after injection, serum melatonin had fallen to 10% (morning) or 4% (evening) of the respective 20-min value. The average half-times for plasma concentration during the second hour after injection were 14 min in the morning and 13 min in the evening. After either morning or evening injection, serum melatonin reached normal daytime concentration between 2 and 4 h after injection.
A Treatise on the Blood: Inflammation and Gunshot Wounds (1984)

This is the kind of book one can occasionally examine only under the watchful eye of a jealous librarian in the rare-book room of a prestigious library. A gorgeous leather-bound, gold-embossed facsimile of Hunter's first edition, it is the first book in the surgical series of the Classics in Medicine. The format of the contemplated 58 future surgical classics is similar to that of other book clubs. It is difficult to interest students or busy practitioners in surgical history. Most are fighting to hold their own against the flood of current literature, and though they sense the value of understanding our professional heritage, it is just too much bother to hunt up copies of classics and browbeat a librarian into permitting a few minutes' reading time. Scholarly historians and senior professors inadvertently make the matter worse by deifying the author. John Hunter is a case in point, both in England
MAdCAM-1 costimulates T cell proliferation exclusively through integrin α4β7, whereas VCAM-1 and CS-1 peptide use α4β1: evidence for “remote” costimulation and induction of hyperresponsiveness to B7 molecules (1998)

We have analyzed the effects of the alpha4 integrin ligands mucosal addressin cell adhesion molecule-1 (MAdCAM-1), vascular cell adhesion molecule-1 (VCAM-1), and the fibronectin CS-1 splice variant on T cell activation. Immobilized MAdCAM-1 and VCAM-1 IgG-Fc chimeras and a fibronectin CS-1 peptide efficiently costimulate T cell proliferation when antigen presentation is mimicked by anti-CD3 antibody. VCAM-1-Fc and fibronectin CS-1, which are adhesive ligands for both the alpha4beta1 and alpha4beta7 integrins, medicate T cell costimulation exclusively through integrin alpha4beta1, but not through alpha4beta7. The inability of VCAM-1-Fc to costimulate via alpha4beta7 suggests that cell adhesion per se is insufficient, and that exquisite recognition and activation events must be triggered. MAdCAM-1-Fc mediates costimulation exclusively via alpha4beta7, and can both synergize with and induce hyperresponsiveness to the classical costimulator B7-2. MAdCAM-1-Fc and VCAM-1-Fc, but not B7-2, effectively costimulate when immobilized on sites spatially distant from the anti-CD3 antibody ("remote" costimulation). In vitro, the relative potencies of the CAM were VCAM-1-Fc> ICAM-1-Fc> MAdCAM-1-Fc > B7-Fc, except at high concentrations where ICAM-1 was the most potent. Features of costimulatory CAM revealed by this study have important implications for the design of immunotherapeutic vaccine strategies to combat cancer and infection.
ChemInform Abstract: Synthesis of Pyrrolizidines by Cascade Reactions of N‐Alkenylaziridinylmethyl Radicals. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hormone-induced Ovulation of Coho Salmon (<i>Oncorhynchus kisutch</i>) Held in Seawater and Fresh Water (1982)

Coho salmon (Oncorhynchus kisutch) mature and spawn naturally in fresh water. We investigated the feasibility of accelerating maturation and/or ovulation of coho salmon retained in seawater during the spawning season, and compared accelerated ovulation of coho salmon in seawater and in fresh water. Effective inducers of ovulation in salmon held in fresh water were partly purified or purified salmon gonadotropin followed 3 d later by luteinizing hormone releasing hormone analogue (LH-RHa); one injection of salmon pituitary extract (SPE); chum salmon pituitary (PIT) followed at 3 d by PIT; and one injection of 17α-hydroxy-20β-dihydroprogesterone. One injection of chinook SPE; coho SPE followed at 3 d by coho SPE; or partly purified or purified salmon gonadotropin followed at 3 d by LH-RHa were effective but to a much lesser extent in those salmon held in seawater. PIT followed at 3 d by PIT, or one injection of 17α-hydroxy-20β-dihydroprogesterane were ineffective in acceleration of maturation/ovulation of coho salmon retained in seawater. Cortisone or 20β-hydroxyprogesterone, which were only tested in salmon in seawater, also failed to elicit early ovulation compared with controls. We conclude that ovarian responses to the treatments of fish retained in seawater are reduced by osmoregulatory difficulties or high adult mortalities. Thus acceleration of ovulation of coho salmon held in seawater is not feasible at this time and requires further research.Key words: coho salmon, spawning, ovulation, induced breeding, gonadotropin, luteinizing hormone releasing hormone analogue
ß‐Subunit of <i>Escherichia coli</i> F<sub>1</sub>‐ATPase (1987)

A mutant strain KF87 of E. coli with a defective beta-subunit (Ala-151----Val) of F1-ATPase was isolated. The mutation is within the conserved sequence (G-X-X-X-X-G-K-T/S) of nucleotide-binding proteins. The mutant F1-ATPase had a much higher rate of uni-site hydrolysis of ATP than the wild type, and about 6% of the wild-type multi-site activity. The mutant enzyme showed defective transmission of conformational change(s) between the ligand- and aurovertin-binding sites.
Breast cancer disparities: Frontline strategies, proceedings of the 7 <sup>th</sup> annual texas conference on health disparities (2012)

There are striking disparities in health status, access to health care, and risk factors among racial and ethnic minorities and the general population in Texas. The disparities are multifactorial comprising genetic, sociocultural, and environmental variables. The Texas Center for Health Disparities (TCHD), a NIMHD Center of Excellence (COE), aims to prevent, reduce, and eliminate health disparities in the communities through research, education, and community-based programs. As part of the center's outreach activities, an annual conference is organized to build awareness and knowledge on health disparities. The overall theme for the 2012 conference was "Battling Breast Cancer Disparities: Frontline Strategies". The scientific program consisted of three sessions: "Breakthroughs in Breast Cancer", "Triple Negative Breast Cancer," and "Hormone Resistant Breast Cancer" featuring different aspects of bench-research from molecular biology, proteomics, and genetics to the clinical aspects such as detection, diagnosis, and finally to community-based approaches. This article summarizes the proceedings of the meeting providing salient strategies and best practices presented by the speakers.
Recurrence of keratoconus in donor cornea 22 years after successful keratoplasty. (1983)

We report a second clinico-pathologic report of recurrent keratoconus in a 43-year-old white female with bilateral penetrating keratoplasties for keratoconus. She was found to have a recurrence of this condition in the right eye as manifested by increasing myopic oblique astigmatism, subepithelial and anterior stromal scarring and corneal thinning, 22 years following the initial grafting procedure. A second successful penetrating keratoplasty was performed. Light and electron microscopy demonstrated abnormalities in the basal epithelium, breaks in the base- ment membrane, duplication and thickening of Bowman's layer, and abnormal stromal keratocytes with accumulation of granular intra-and extracellular material. These findings are consistent with changes as seen in keratoconus.
Design criteria for tunable matching networks: a MEMS perspective in the FM band (2006)

A tunable matching network selection rationale is given. Specific emphasis is dedicated towards MEMS components in the FM band. An extremely useful and important result is reached proving that minimal number of components is required to match a range of loads in the complete band. The design approach is more accurate than the Smith chart approach and takes into account parasitic effects. The network can be used in intelligent RF front ends.
Long-term outcome and patterns of failure in patients with advanced head and neck cancer (2011)

In stage IV HNSCC long-term survival is rare and DM is a significant predictor for mortality. If patients developed DM, lung metastases had the most favourable prognosis, so intensified palliative treatment might be justified in DM limited to the lungs.
Granzyme A Activates an Endoplasmic Reticulum-associated Caspase-independent Nuclease to Induce Single-stranded DNA Nicks (2001)

The cytotoxic T lymphocyte protease granzyme A (GzmA) initiates a novel caspase-independent cell death pathway characterized by single-stranded DNA nicking. The previously identified GzmA substrate SET is in a multimeric 270-420-kDa endoplasmic reticulum-associated complex that also contains the tumor suppressor protein pp32. GzmA cleaved the nucleosome assembly protein SET after Lys(176) and disrupted its nucleosome assembly activity. The purified SET complex required only GzmA to reconstitute single-stranded DNA nicking in isolated nuclei. DNA nicking occurred independently of caspase activation. The SET complex contains a 25-kDa Mg(2+)-dependent nuclease that degrades calf thymus DNA and plasmid DNA. Thus, GzmA activates a DNase (GzmA-activated DNase) within the SET complex to produce a novel form of DNA damage during cytotoxic T lymphocyte-mediated death.
Factor XIII Deficiency (2009)

Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. By cross-linking fibrin chains and alpha (2) plasmin inhibitor to fibrin, FXIIIa mechanically stabilizes fibrin and protects it from fibrinolysis. Severe deficiency of the potentially active A subunit (FXIII-A) is a rare but severe hemorrhagic diathesis. Delayed umbilical stump bleeding is characteristic, and subcutaneous, intramuscular, and intracranial bleeding occurs with a relatively high frequency in nonsupplemented patients. In addition, impaired wound healing and spontaneous abortion in women are also features of FXIII deficiency. The extremely rare B subunit deficiency results in milder bleeding symptoms. FXIII concentrate is now available for on-demand treatment and primary prophylaxis. A quantitative FXIII activity assay is recommended as a screening test for the diagnosis of FXIII deficiency. For classification purposes, FXIII-A (2)B (2) antigen in the plasma is first determined, and if decreased, further measurement of the individual subunits is recommended in the plasma and FXIII-A in platelet lysate. Analytical aspects of FXIII activity and antigen assays are discussed in this article. There are no hot-spot mutations in the F13A1 and F13B genes, and the majority of causative mutations are missense/nonsense point mutations.
Study of the Influence of Thin Cirrus Clouds on Satellite Radiances Using Raman Lidar and GOES Data (2000)

Hurricane-induced cirrus cloud optical depths (at 351 nm) are presented for the night of August 23, 1998. Optical depths ranged from approximately 0.01 to 0.7 after correcting for multiple scattering, which was estimated to reduce the measured optical depths by up to 20%. The ultraviolet/infrared (UV/IR) cirrus cloud optical depth ratio was estimated based on a comparison of lidar and Geostationary Operational Environmental Satellite (GOES) satellite measurements. Simple radiative transfer model calculations compared with GOES satellite brightness temperatures indicate that satellite radiances are significantly affected by the presence of cirrus clouds if IR optical depths are approximately 0.02 or greater. This has implications for satellite cirrus detection requirements.
Temperature dependence of spin-transport properties and spin torque in a magnetic nanostructure (2020)

The study and understanding of spin-transport mechanisms including thermal fluctuation are required for the development and design of spintronic devices. In this paper, we present an approach to investigate the temperature dependence of spin-transport behavior within the magnetic structure by using the generalized spin accumulation model. The temperature affects not only the magnetization orientation, but also the spin-transport properties. Its effect on transport parameters can be taken into account by considering the spin-dependent resistivity at any finite temperature. This leads to the calculation of temperature-dependent spin-transport parameters and eventually allows the calculation of the thermal effects on spin accumulation, spin current, and spin torque. It is observed that increasing temperature is likely to decrease the value of key transport parameters relevant to the magnitude of spin torque. This study demonstrates the importance of thermal effects on spin-transport behavior which needs to be considered for spin-transfer torque based device design with high performance.
Abstract WP15: Stent Retriever Thrombectomy After Intravenous Tissue Plasminogen versus Intravenous Tissue Plasminogen Activator Alone In Japan : J-ASPECT Japan (2018)

Objective: We performed a nationwide study to evaluate the effectiveness of stent-retriever in addition to intravenous thrombolysis in acute ischemic stroke patients in the ‘‘real-world’’ settings. Methods: This was a retrospective cohort study using the Diagnosis Procedure Combination nationwide inpatient database in Japan. Patients with acute ischemic stroke who were admitted to hospitals between April 1, 2013, and March 31, 2014 were identified. The rate of functional independence (modified Rankin scale score, 0 to 2) at discharge and mortality at 30 days were compared between patients who received intravenous thrombolysis alone (IVT group) and those who received stent-retriever after intravenous thrombolysis (IVET group) using 1:1 propensity score-matching. Results: In total, 71,519 acute ischemic patients were identified in a year. Among those, 3,367 patients were eligible (3,110 in IVT group and 257 in IVET group). Post-matching, 134 pairs of patients were analysed. The rate of functional independence at discharge was higher in IVET group than in IVT group (odds ratio 1.96, 95% CI 1.16-3.35; p=0.012). In addition, there was no significant differences in mortality at 30 days between the two groups (odds ratio 1.80, 95% CI 0.81-4.23; p=0.153). Conclusion: This nationwide study revealed that mechanical thrombectomy with stent-retriever in addition to intravenous thrombolysis improves functional outcomes in patients with acute ischemic stroke, and with no evidence of increased mortality. A randomized clinical trial seems warranted.
Pressure mapping at orthopaedic joint interfaces with fiber Bragg gratings (2006)

We present the concept of a fiber-optic sensor that can be used for pressure mapping at the prosthetic knee joint, in vitro and in vivo. An embedded array of fiber Bragg gratings is used to measure the load on the tibial spacer. The sensor gives the magnitude and the location of the applied load. The effect of material properties on the sensitivity of each subgrating is presented. The wavelength-shift maps show the malalignment of implants and demonstrate the potential of this sensor for use during total knee arthroplasty.