gebhart/patrepeval huggingface dataset:
Low Activities of ^|^beta;-Glucuronidase, ^|^beta;-Glucosidase and Urease in Faeces Are Associated with Active Crohn's Disease (1999)

To evaluate whether intestinal microecology is altered in Crohn's disease, we studied the metabolic activity of faecal flora and its bacteriology. Metabolic activity was analysed by measuring the activities of β-glucuronidase, β-glucosidase and urease in faeces, based on enzyme-substrate reactions, from 24 patients (aged 5-51 years) with Crohn's disease as compared to 16 controls (4-62 years). Faecal bacteriology was determined by analysing bacterial cellular fatty acid profiles by gas-liquid chromatography assay in a subgroup of the study subjects. In Crohn's disease the mean (95% confidence interval) activities of β-glucuronidase: 1.6 (0.9-2.2) nmol/min/mg protein, β-glucosidase: 3.9 (2.4-5.3) and urease: 6.1 (2.9-9.2) were significantly lower than in controls: 3.6 (2.3-4.9), 7.6 (5.6-9.5), 18.1 (11.1-25.0), respectively, p < 0.004. The faecal enzyme activities in Crohn's disease were associated with disease activity: the more active the disease, the lower the enzyme activity. Also faecal bacterial cellular fatty acid profiles in Crohn's disease patients with active disease tended to differ from controls. We suggest that in active Crohn's disease intestinal microecology is altered, in particular, its metabolic activity, which may have a role in the pathogenesis of Crohn's disease.
Repeat balloon aortic valvuloplasty for aortic valve restenosis (1989)

Effective balloon aortic valvuloplasty (BAV) is limited restenosis. After aortic valve restenosis six patients underwent repeat BAV. In spite of the use of larger balloons there was a trend toward a less satisfactory result after repeat BAV (0.98 +/- .26 cm2 vs. 1.2 +/- .26 cm2), which did not reach statistical significance, P = .14. Mortality of the patients at 6 months was 50%. Repeat BAV may be less efficacious than the original procedure.
Periplasmic orientation of nascent lipid A in the inner membrane of an <i>Escherichia coli</i> LptA mutant (2008)

The core-lipid A domain of Escherichia coli lipopolysaccharide (LPS) is synthesized on the inner surface of the inner membrane (IM) and flipped to its outer surface by the ABC transporter MsbA. Recent studies with deletion mutants implicate the periplasmic protein LptA, the cytosolic protein LptB, and the IM proteins LptC, LptF, and LptG in the subsequent transport of nascent LPS to the outer membrane (OM), where the LptD/LptE complex flips LPS to the outer surface. We have isolated a temperature-sensitive mutant (MB1) harboring the S22C and Q111P substitutions in LptA. MB1 stops growing after 30 min at 42 degrees C. (32)P(i) and [(35)S]methionine labeling show that export of newly synthesized phospholipids and proteins is not severely impaired, but export of LPS is defective. Using the lipid A 1-phosphatase LpxE as a periplasmic IM marker and the lipid A 3-O-deacylase PagL as an OM marker, we show that core-lipid A reaches the periplasmic side of the IM at 42 degrees C in MB1 but not the outer surface of the OM. Electron microscopy of MB1 reveals dense periplasmic material and a smooth OM at 42 degrees C, consistent with a role for LptA in shuttling LPS across the periplasm.
Three-dimensional high-frequency distribution networks. II. Packaging and integration (2000)

This paper describes the implementation and packaging of the components, described in Part I of this paper, to realize a three-dimensional W-band distribution network.
Aus der Vergangenheit des Ostseebades Kahlberg (1914)

Jeszcze na początku XIX w. Krynica Morska byla malenką rybacką osadą (w 1814 r. mieszkalo tam zaledwie czterech rybakow). Do rozwoju Krynicy Morskiej jako miejscowości letniskowej i kąpieliska przyczynilo sie zalozenie spolki akcyjnej dla utworzenia zeglugi parowcowej miedzy Elblągiem a Krolewcem. Początkowo goście kąpieliska mieszkali w pokojach wynajmowanych w prywatnych domach mieszkancow i musieli zadowalac sie skromnymi warunkami i brakiem wygod. Dopiero w latach czterdziestych powstaly dwa zajazdy: „Hoffnung” („Nadzieja”) i Belvedere. Dla rozwoju tej miejscowości kąpieliskowej zasluzony byl Georg Wilhelm Haertel, wlaściciel elbląskiej fabryki rumu, likierow i cykorii. W 1814 r. wybudowal on dom kąpielowy nad rzeką Elbląg. Byl tez wspolzalozycielem Towarzystwa Upiekszania Elbląga oraz (razem z m. in. I. Grunau’em) spolki akcyjnej Kąpielisko Krynica Morska.
Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. (2001)

In this study, a panel of normal human prostate cells (HPCs) and tumor cells derived from metastases were studied by (1)H NMR spectroscopy to determine whether the malignant transformation of HPCs results in the elevation of choline compounds. Although an elevated choline signal has been observed previously in clinical studies, the contribution of the different Cho compounds to this elevation, as well as their quantification, has not been established until now. Here we have shown that HPCs derived from metastases exhibit significantly higher phosphocholine as well as glycerophosphocholine levels compared with normal prostate epithelial and stromal cells. Thus the elevation of the choline peak observed clinically in prostate cancer is attributable to an alteration of phospholipid metabolism and not simply to increased cell density, doubling time, or other nonspecific effects. Androgen deprivation of the androgen receptor-positive cell lines resulted in a significant increase of choline compounds after chronic androgen deprivation of the LNCaP cell line and in a decrease of choline compounds after a more acute androgen deprivation of the LAPC-4 cell line. These data strongly support the use of proton magnetic resonance spectroscopic imaging to detect the presence of prostate cancer for diagnosis, to detect response subsequent to androgen ablation therapy, and to detect recurrence.
A high-speed mass flow sensor with heated silicon carbide bridges (2002)

A novel type of micromachined thermal mass flow sensor has been developed which is characterised by enhanced mechanical and thermal stability. For its realisation /spl beta/-SiC films were heteroepitaxially deposited onto pre-processed silicon wafers. After structuring the surface /spl beta/-SiC films to form heater and temperature sensing elements, porous silicon was formed in predetermined parts of the silicon substrate to form flow channels. The so formed devices are able to detect bidirectional flows of air with a temporal resolution of 2-3 msec. Due to the excellent mechanical and thermal stability of the /spl beta/-SiC heater and temperature sensing elements, the devices are able to sustain extremely harsh environmental and operating conditions: firstly, flows of pressurised air could be sustained without inflicting mechanical damage to the micromachined /spl beta/-SiC bridges, secondly, several hours of thermal cleaning at white glow in ambient air could be endured before breakages due to thermal oxidation occurred.
Assessment of Sleep in Women With Night Eating Syndrome (2006)

Patients with NES appear to have sleep maintenance insomnia rather than sleep-related eating disorder or a parasomnia. The maintenance of normal timing for sleep-wake behavior in the presence of a phase delay in the timing of caloric intake suggests this disorder reflects a state of internal circadian desynchrony associated with significant sleep complaints. It remains unknown whether the sleep disturbance precedes the abnormally timed eating.
Reduction of Truncation Errors in Planar Near-Field Aperture Antenna Measurements Using the Gerchberg-Papoulis Algorithm (2008)

A simple and effective procedure for the reduction of truncation errors in planar near-field measurements of aperture antennas is presented. The procedure relies on the consideration that, due to the scan plane truncation, the calculated plane wave spectrum of the field radiated by the antenna is reliable only within a certain portion of the visible region. Accordingly, the truncation error is reduced by extrapolating the remaining portion of the visible region by the Gerchberg-Papoulis iterative algorithm, exploiting a condition of spatial concentration of the fields on the antenna aperture plane. The proposed procedure is simple and computationally efficient; it does not require any modification of the measurement procedure and it allows for the usual probe correction. Far-field patterns reconstructed from both simulated and measured truncated near-field data demonstrate its effectiveness and stability against measurement inaccuracies.
A functional role for signal transduction via the cytoplasmic domains of MHC class II proteins. (1989)

B cell transfectants expressing MHC class II (Ia) molecules with truncated cytoplasmic domains are defective in both antigen presentation and in anti-Ia induced intracellular signaling. In this report we show that the Ag presentation defect in a truncated-Ia expressing transfectant can be overcome by providing the second messenger for the Ia-mediated signaling event. Preincubation with dibutyryl-cAMP restored the ability of the truncated Ia expressing-transfectant to stimulate IL-2 release by otherwise nonresponsive T hybrids. This provides direct functional evidence that signaling via the cytoplasmic domains of MHC class II proteins leads to the generation of accessory signals in the B cell that are important in T cell activation. The dibutyryl-cAMP induced signal must be on the same cell as the restricting element, does not bypass the requirement for occupancy of the T cell receptor with its normal ligand, and is lost upon fixation of the cells. Thus T cell-B cell interaction involves a two way communication in which both cells sense and respond to the formation of the antigen/MHC/TCR complex.
Modeling Werner Syndrome in <i>Drosophila melanogaster</i> (2007)

Human progeroid Werner syndrome provides the current best model for analysis of human aging, recapitulating many aspects of normal aging as a result of mutation of the WRN gene. This gene encodes a RecQ-type helicase with additional exonuclease activity. While biochemical studies in vitro have proven invaluable in determining substrate specificities of the WRN exonuclease and helicase, it has been difficult to dissociate the two key enzyme activities in vivo. We are developing Drosophila as a model system for analysis of WRN function; the suitability of Drosophila for extensive and sophisticated genetic manipulation permits us to investigate regulatory pathways and the impact of WRN loss at organismal, cellular, and molecular levels. BLASTP screening of the Drosophila genome with human WRN sequence allowed us to identify three RecQ helicases with strong homology to human WRN, a presumed helicase component of the spliceosome, and two DEAH-box putative RNA helicases with weaker WRN homology. None of these helicases contain a WRN-like exonuclease domain, but two potential WRN-like exonucleases in flies encoded by the loci CG7670 and CG6744 were also identified in the BLAST search. CG6744 and CG7670 are more closely related to human WRN than to each other. We have obtained a fly strain with a piggyBac insertional mutation within the CG6744 locus, which decreases expression of the encoded mRNA. Such flies show elevated levels of somatic recombination. We suggest that WRN-like exonuclease activity is critical in maintaining genomic integrity in flies.
Geometric and electronic structures of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi mathvariant="normal">Si</mml:mi><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mo>/</mml:mo><mml:mi mathvariant="normal">Si</mml:mi><mml:mn/><mml:mo>(</mml:mo><mml:mn>001</mml:mn><mml:mo>)</mml:mo><mml:mn/></mml:math>interfaces (2001)

Interface structures of ${\mathrm{SiO}}_{2}/\mathrm{Si}(001)$ are studied by using the first-principles molecular-dynamics method. Three crystalline phases of the ${\mathrm{SiO}}_{2},$ cristobalite, quartz, and tridymite, are stacked on the Si(001) substrate and are fully relaxed. When the ${\mathrm{SiO}}_{2}$ layer is very thin (\ensuremath{\sim}7 \AA{}), the lowest-energy structure is the tridymite, followed by the quartz phase. As the ${\mathrm{SiO}}_{2}$ layer becomes thicker (\ensuremath{\sim}15 \AA{}), the quartz phase has lower energy than the tridymite phase. The cristobalite phase on Si(001) is unstable due to large lattice mismatch, and transforms into a different crystal structure. No defects appear at the interface after the successive bond breaking and rebonding, but the energy of the resulting structure is the highest irrespective of the thickness. Calculations of the local density of states show that the band-gap change occurs on the ${\mathrm{SiO}}_{2}$ side, resulting in an effective decrease of the oxide thickness by 2--5 \AA{}.
Respiratory Insufficiency Secondary to Acute Pancreatitis (1972)

KELLUM, JOHN M. JR. M.D.; DEMEESTER, TOM R. M.D.; ELKINS, RONALD C. M.D.; ZUIDEMA, GEORGE D. M.D. Author Information
In vivo 3D spatial/1D spectral imaging by spatiotemporal encoding: A new single‐shot experimental and processing approach (2012)

A novel method for acquiring and processing quality multislice spectroscopically resolved 2D images in a single shot is introduced and illustrated. By contrast to the majority of single-scan spectroscopic imaging sequences developed so far, the method here discussed is not based on the acquisition of echo planar data in the k/t-space, but rather on the use of recently proposed spatiotemporal encoding methods. These techniques provide a robust alternative to classical techniques, as they can scan two spatial plus one spectral dimension by oscillating a single imaging gradient. This work demonstrates that the use of extended spectral/spatial super-resolution algorithms coupled to new experimental spatiotemporal encoding formulations based on swept inversions rather than on chirped excitations can lead to novel spatiotemporal encoding-based tools for resolving complex multisliced 2D images according to the chemical shifts in subsecond experiments. A number of phantom-based models were explored to clarify the relative merits of this technique and estimate its sensitivity performance. In vivo results of fat and water separation on abdominal imaging of mice at 7 T and on human breast imaging at 3 T are presented.
The Effect of Infusions of Adrenaline, Noradrenaline and Dopamine on Cerebral Autoregulation under Isoflurane Anaesthesia in an Ovine Model (2003)

The effects of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under steady-state isoflurane anaesthesia were compared with the awake state. Six studies each were conducted in two cohorts of adult ewes: awake sheep and those anaesthetized with 2% isoflurane anaesthesia. In random order, each animal received ramped infusions of adrenaline, noradrenaline (0-40 micrograms/min) and dopamine (0-40 micrograms/kg/min). Cerebral blood flow was measured continuously from changes in Doppler velocities in the sagittal sinus. Autoregulation was determined by linear regression analysis between cerebral blood flow and mean arterial pressure. Isoflurane did not significantly alter cerebral blood flow relative to pre-anaesthesia values (P > 0.05). All three catecholamines significantly and equivalently increased MAP from baseline in a dose dependent manner in both the awake and isoflurane cohorts. Although adrenaline significantly increased cerebral blood flow from baseline in the awake cohort (P < 0.01), none of the catecholamines significantly increased cerebral blood flow during isoflurane anaesthesia. No significant differences were demonstrated between the slopes and intercepts of regression lines for adrenaline, noradrenaline and dopamine within either cohort (ANCOVA). Inter-cohort comparisons between the two autoregulation curves demonstrated no significant difference between the slopes of the autoregulation curves for the awake (pooled slope = 0.39) and isoflurane cohorts (pooled slope = 0.28) (P > 0.05). Over a specific dose range, systemic hypertension induced by adrenaline, noradrenaline and dopamine did not significantly increase cerebral blood flow under 2% isoflurane anaesthesia. The concomitant administration of isoflurane and the catecholamines was not associated with altered autoregulatory function compared to the awake state.
In vitro activity of methanolic extract from Lagerstroemia speciosa (Linn. ex. Murray) bark against pathogenic bacteria (2013)

Crude methanolic extract of Lagerstroemia speciosa barks (Linn. ex. Murray) was subjected to antimicrobial screening including six Gram-positive and eight Gram-negative bacteria. The extract demonstrated significance antibacterial activities on 5 tested bacteria with the inhibition zone ranging from 10-15 mm. The minimum inhibitory concentration (MIC) of the extract was assessed by microdilution method. MIC value of Bacillus spizizenii ATCC6633, Bacillus cereus and Streptococcus coagulase-negative (SCN) was 0.25 mg/ml whilst Bacillus licheniformis and Acinetobacter anitratus showed MIC value of 0.50 mg/ml. However, only B. spizizenii ATCC6633 and B. licheniformis showed the minimum bactericidal concentration (MBC) value of 2.00 mg/ml and 1.00 mg/ml, respectively. The morphological changes of B.spizizenii ATCC6633 and A. anitratus with the treatment of the extract were observed under Scanning Electron Microscope (SEM). The results suggested that the L. speciosa methanolic extract had caused membrane structural degenerations of the cells and finally leading to cell-lysis.
Quinazolines. XIII. A Study of the Infrared Spectra of Certain Quinazoline Derivatives<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuinazolines. XIII. A Study of the Infrared Spectra of Certain Quinazoline Derivatives1Harry Culbertson, J. C. Decius, and Bert E. ChristensenCite this: J. Am. Chem. Soc. 1952, 74, 19, 4834–4838Publication Date (Print):October 1, 1952Publication History Published online1 May 2002Published inissue 1 October 1952https://pubs.acs.org/doi/10.1021/ja01139a031https://doi.org/10.1021/ja01139a031research-articleACS PublicationsRequest reuse permissionsArticle Views192Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cascaded active and passive quasi-optical grids (1995)

A general method for analyzing systems of cascaded grids is presented. The analysis is based on a full-wave theory for arbitrary periodic metal gratings printed on dielectrics and loaded with active and/or passive lumped devices. Each quasioptical component is characterized as a multiport network, in which two of the ports represent the free-space regions on the two sides of the grid surface, and the remaining ports are connected to the devices. This approach allows cascading of quasi-optical components using transmission-line theory. Several examples are presented which demonstrate the theory: free-space filters containing lumped capacitors and resistors; an X-band transmission-mode linear-to-circular polarization converter; an S-band voltage-controlled frequency-selective surface; and a C-band mode-selective grid oscillator.
Phase measuring Ronchi test (1988)

Use of synchronous phase detection in the conventional Ronchi test is discussed to measure a large amount of wavefront aberration or an aspheric wavefront. This method provides a simple but powerful tool for aspheric surface evaluation. By moving the Ronchi grating sideways, a periodic phase shift in the Ronchigram is introduced for synchronous phase detection. A theoretical interpretation of the Ronchigram and the procedure for an analysis are presented, and experimental results are shown.
<sup>19</sup>F NMR Fingerprints: Identification of Neutral Organic Compounds in a Molecular Container (2014)

Improved methods for quickly identifying neutral organic compounds and differentiation of analytes with similar chemical structures are widely needed. We report a new approach to effectively "fingerprint" neutral organic molecules by using (19)F NMR and molecular containers. The encapsulation of analytes induces characteristic up- or downfield shifts of (19)F resonances that can be used as multidimensional parameters to fingerprint each analyte. The strategy can be achieved either with an array of fluorinated receptors or by incorporating multiple nonequivalent fluorine atoms in a single receptor. Spatial proximity of the analyte to the (19)F is important to induce the most pronounced NMR shifts and is crucial in the differentiation of analytes with similar structures. This new scheme allows for the precise and simultaneous identification of multiple analytes in a complex mixture.
Coherence resonance in an autapse neuron model with time delay (2007)

We study the noise activated dynamics of a model <i>autapse</i> neuron system that consists of a subcritical Hopf oscillator with a time delayed nonlinear feedback. The coherence of the noise driven pulses of the neuron exhibits a novel double peaked structure as a function of the noise amplitude. The two peaks correspond to separate optimal noise levels for excitation of single spikes and multiple spikes (bursts) respectively. The relative magnitudes of these peaks are found to be a sensitive function of time delay. The physical significance of our results and its practical implications in various real life systems are discussed.
Progress in adsorption-based CO<sub>2</sub>capture by metal–organic frameworks (2011)

Metal-organic frameworks (MOFs) have recently attracted intense research interest because of their permanent porous structures, large surface areas, and potential applications as novel adsorbents. The recent progress in adsorption-based CO(2) capture by MOFs is reviewed and summarized in this critical review. CO(2) adsorption in MOFs has been divided into two sections, adsorption at high pressures and selective adsorption at approximate atmospheric pressures. Keys to CO(2) adsorption in MOFs at high pressures and low pressures are summarized to be pore volumes of MOFs, and heats of adsorption, respectively. Many MOFs have high CO(2) selectivities over N(2) and CH(4). Water effects on CO(2) adsorption in MOFs are presented and compared with benchmark zeolites. In addition, strategies appeared in the literature to enhance CO(2) adsorption capacities and/or selectivities in MOFs have been summarized into three main categories, catenation and interpenetration, chemical bonding enhancement, and electrostatic force involvement. Besides the advantages, two main challenges of using MOFs in CO(2) capture, the cost of synthesis and the stability toward water vapor, have been analyzed and possible solutions and path forward have been proposed to address the two challenges as well (150 references).