gebhart/patrepeval huggingface dataset:
Effects of bacterial lipopolysaccharide on the binding of lymphocytes to endothelial cell monolayers. (1986)

Preincubation of human umbilical vein endothelial cell (EC) monolayers with 1 ng to 10 micrograms/ml lipopolysaccharide (LPS) increased the binding of T lymphocytes to EC. The effect was maximal at LPS concentrations of 0.1 to 10 micrograms/ml, and occurred with LPS derived from Escherichia coli (serotypes 0111:B4 and 0127:B8), Shigella flexneri (serotype 2a), Serratia marcescens (serotype 0:3), and Yersinia entercolitica (serotype 0:3). The increased binding appeared to be mediated primarily through an action on EC; preincubation of T cells rather than EC with LPS did not lead to enhanced binding. The onset of enhanced binding was very rapid, being observed after 2 to 3 min of preincubation and becoming maximal after 1 hr. EC were unresponsive to LPS after fixation with 2% paraformaldehyde-L-lysine-periodate and also when the LPS was incubated with EC at 4 degrees C. Enhanced binding was seen with lipid A and with LPS from Salmonella minnesota Re 595 (mainly lipid A) and was abolished by conjugation with polymyxin B. The observed increase in the binding of lymphocytes to EC exposed to LPS suggests that the lymphocytopenia induced by endotoxemia may result from augmentation of the adherence of lymphocytes to altered endothelium.
EFFECTS OF 5-IDOO-2-DESOXYURIDINE (IDU) ON HERPESVIRUS SYNTHESIS AND SURVIVAL IN INFECTED CELLS. (1964)

Summary Treatment of cells with IDU immediately following a 2-hr period of virus adsorption completely suppressed the production of new infectious virus but did not prevent the synthesis of new viral components. Both fluorescent and electron microscopy revealed the formation of large amounts of viral material in drug-treated, infected cells, although most input infectious virus disappeared. Ragged, naked, structurally imperfect particles were produced in the presence of IDU. It appeared, therefore, that the antiviral activity of IDU was due to an interruption in the assembly of viral components, not in their production .
Rapid and Efficient Pd-Catalyzed Sonogashira Coupling of Aryl Chlorides (2008)

An efficient and effective microwave-assisted cross-coupling of terminal alkynes with various aryl chlorides including sterically hindered, electron-rich, electron-neutral, and electron-deficient aryl chloride is developed. It proceeds faster and generally gives good to excellent yields and also can be extended successfully to the Suzuki coupling and Buchwald-Hartwig amination, as well as the Heck coupling with inert aryl chlorides. The short reaction times and simple reaction conditions coupling with a broad substrate scope render this method particularly attractive for the efficient preparation of biologically and medicinally interesting molecules.
A motion planner for nonholonomic mobile robots (1994)

This paper considers the problem of motion planning for a car-like robot (i.e., a mobile robot with a nonholonomic constraint whose turning radius is lower-bounded). We present a fast and exact planner for our mobile robot model, based upon recursive subdivision of a collision-free path generated by a lower-level geometric planner that ignores the motion constraints. The resultant trajectory is optimized to give a path that is of near-minimal length in its homotopy class. Our claims of high speed are supported by experimental results for implementations that assume a robot moving amid polygonal obstacles. The completeness and the complexity of the algorithm are proven using an appropriate metric in the configuration space R/sup 2//spl times/S/sup 1/ of the robot. This metric is defined by using the length of the shortest paths in the absence of obstacles as the distance between two configurations. We prove that the new induced topology and the classical one are the same. Although we concentrate upon the car-like robot, the generalization of these techniques leads to new theoretical issues involving sub-Riemannian geometry and to practical results for nonholonomic motion planning.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Transformation Kinetics of Thermomechanically Worked Austenite by Deformation Dilatometry (1970)

A method was developed for monitoring the continuous cooling transformation of thermomechanically worked austenite by dilatometry. A commercially available, induction-heated, gas-quenching dilatometer was modified by the addition of a compression device that permitted the deformation of dilatometer specimens at high temperature. Continuous cooling transformation data were obtained on undeformed and thermomechanically worked specimens of a 0.1C-0.4Mo-B structural steel. The results clearly indicate the need for data on transformation kinetics in the selection of steel compositions for processing by thermomechanical working schedules.
A Soluble Chloroplast Protease Processes the Euglena Polyprotein Precursor to the Light Harvesting Chlorophyll a/b Binding Protein of Photosystem II (1997)

The Euglena light harvesting chlorophyll a/b binding protein of photosystem II (LHCPII) is synthesized as a polyprotein precursors composed of 8 LHCPIIs covalently joined by a decapeptide. A soluble chloroplast protease releases LHCPII from the polyprotein. The polyprotein processing peptidase has a pH optima between 8.0 and 9.0. It is inhibited by Zn2+, Cu2+, phenylmethylsulfonyl fluoride and E64 suggesting it is a novel thiol protease.
The Idea of Enhancing Directional Energy Radiation by a Phased Antenna Array in UHF RFID System (2016)

Abstract The interrogation zone IZ is the most important parameter when RFID systems are considered. Its predictability is determined by the construction and parameters of antenna built in a read/write device. The IZ should be of sufficient size and appropriate to requirements established for an application of object automated identification. The method of shaping an antenna radiation pattern provides effective yet unconventional opportunities in this area. The idea and practical solution of the phased antenna array dedicated to UHF read/write devices are presented in the paper. On the basis of tests carried out, the authors pointed out the possibility of using developed devices for the synthesis of a determined IZ in anti-collision RFID system.
Glucocorticoid-induced osteoporosis in rheumatic diseases (2010)

The aim of this article is to review rheumatological diseases that are associated with glucocorticoid-induced osteoporosis or fractures and to perform a critical analysis of the current guidelines and treatment regimens. The electronic database MEDLINE was searched using the date range of July 1986 to June 2009 and the following search terms: osteoporosis, bone mineral density, fractures, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, vasculitis, juvenile rheumatoid arthritis, juvenile idiopathic arthritis and juvenile dermatomyositis. Osteopenia and osteoporosis respectively account for 1.4 to 68.7% and 5.0 to 61.9% of adult rheumatological diseases. Among juvenile rheumatological disorders, the frequency of low bone mass ranges from 38.7 to 70%. In general, fracture rates vary from 0 to 25%. Although glucocorticoid-induced osteoporosis has a high rate of prevalence among rheumatic diseases, a relatively low number of patients on continuous glucocorticoid treatment receive adequate diagnostic evaluation or preventive therapy. This deficit in patient care may result from a lack of clear understanding of the attributed risks by the patients and physicians, the high complexity of the treatment guidelines and poor patient compliance.
SIMULTANEOUS OPERATIONS FOR LIVER ECHINOCOCCOSIS (2021)

Objective. To evaluate the results and effectiveness of simultaneous operations for echinococcosis of the liver. Methods. Surgical diseases requiring surgical treatment (cholelithiasis: calculus cholecystitis, choledocholithiasis, nodular goiter, ventral postoperative hernia) were detected in 38 patients with echinococcosis of the liver. 23 patients underwent organ-preserving operations for echinococcosis, and 15 patients underwent radical operations, all operations were perfomed in combined with cholecystectomy, choledocholitotomy, thyroidectomy, and herniotomy (coating of a polypropylenemesh for hernia gate).Immediate and remote results were studied. Patients were reexamined 6 months after surgery within a 3-year period. The examination included the checkup, general blood test, liver and kidney tests, an ultrasound examination of the abdominal organs, and a chest x-ray once a year. Results. During theimmediate postoperative period 4 patients out of 38 (10.5%) had complications. After simultaneous operations using organ-preserving methods of echinococcectomy, 2 patients out of 23 (8.7%) had complications (pleuritis, wound suppuration), and 2 - out of 15 had radical operations (bile leakage, pleuritis). All complications had been cured by the time of discharge. The remote results were studied over a period of 6 months to 3 years. 34 patients were examined up to 1 year, 31 - from 1 to 2 years, 26 - from 2 to 3 years. Within the examination and follow-up periods no recurrence of echinoccosis was observed. Conclusion. During simultaneous operations and the echinococcectomy of the liver it is necessary to observe accurately the rules of aparasiticity and antiparasiticity.Simultaneous operations for the liver echinococcosis should be performed according to strict indications and by a highlyexperiencedandqualified surgeon. Patients who have undergone simultaneous operations was asked toundergoa medicalcontrol examination at least once a year. What this paper adds The possibility of performing simultaneous operations for echinococcosis of the liver has been defined. The sequence of operations for echinococcosis in combination with other pathologies requiring surgical treatment has been justified.
Presidential address, 1989. The future of vascular surgery in Canada. (1991)

There has been an explosion of technology in the field of vascular surgery in the latter half of the 1980s. Laser procedures, atherectomy catheterization, intra-arterial stenting and balloon angioplasty have all been demonstrated, with varied degrees of success, to play a role in the management of the patient with vascular disease. Vascular surgeons must be wary of unproven devices that come complete with extravagant claims of success. But, they should also show an interest in new technology as it comes along and should be prepared to become involved in its scientific evaluation. Some of these techniques, perhaps in a more refined state, will play an important role in patient care in the future. Vascular surgeons in Canada must also develop their interests and knowledge of circulatory hemodynamics by committing themselves to using duplex scanning equipment in their diagnostic vascular laboratories. Such laboratories must be staffed by thoroughly trained directors and technologists, and to do this, we must look to making vascular laboratory training part of the requirements for fellowship in the Royal College of Physicians and Surgeons of Canada.
How Nature Synthesizes Vitamin B<sub>12</sub>A Survey of the Last Four Billion Years (1993)

Abstract This review contains an account of recent experimental results in the continuing saga of vitamin B 12 biosynthesis (largely from the author's laboratory) as well as a personal view of future directions of research in natural product biosynthesis. The emphasis is on the powerful combination of molecular biology in the search for, and the expression of, the genes encoding the biosynthetic enzymes and state‐of‐the‐art spectroscopic techniques, in order to “view” the biochemical events as they take place in the NMR tube. As a logical development of these approaches, the feasibility of one‐flask, multienzyme synthesis of natural products is addressed.[ Based on a lecture given at the 27th Euchem Conference on Stereochemistry, 26th April to 4th May, 1992. Bürgenstock, Switzerland. A more explicit account of this new field has been given in “Genetically Engineered Synthesis of Complex Natural Products” (A. I. Scott Terruhedron , 1992 , 48 , 2559). ] Implicit throughout is the profound change in the “tools of the trade” of the bioorganic chemist, thanks to the harnessing and exploitation of cloning techniques and the resultant availability of enzymes which can make carbon‐carbon bonds. It is also our desire to alert organic chemists, who may wish to take advantage of these technical developments, to the fact that they will be rewarded by a new world of natural catalysts capable of high yielding, synthetic chemistry often with a surprising, but welcome, lack of substrate specificity. Finally we hope to convey our enthusiasm for the methods now at the disposal of present and future generations of chemists for studying Nature's synthetic routes to complex natural products.
Touching Words: Finding Tradition Through Translation Among Seferis, Eliot, and Keats (2003)

The relation is a feeling of profound kinship, or rather of a peculiar personal intimacy, with another, probably a dead author. It may overcome us suddenly, on first or after long acquaintance; it is certainly a crisis; and when a young writer is seized with his first passion of this sort he may be changed, metamorphosed almost, from a bundle of second-hand sentiments into a person. T. S. Eliot, The Egoist July 1919
The effect of carbon black on thermal antioxidants for polyethylene (1959)

Abstract About 3% by weight of carbon black adequately protects polyethylene against photo‐oxidation and, under accelerated test conditions, slightly inhibits thermal oxidation. As a rule small amounts of organic antioxidants are also added to the polymer for optimum protection. Now many of the common phenolic and amine additives have been found to function much less effectively in polyethylene containing carbon black than in clear polymer. Loss of effectiveness is attributed to adsorption and/or decomposition of the antioxidant by both basic and acidic carbon black.
Reaction of Sodium Tris(diethylamino)aluminum Hydride with Selected Organic Compounds Containing Representative Functional Groups (1994)

The approximate rates and stoichiometry of the reaction of excess sodium tris(diethylamino)aluminum hydride (ST-DEA) with selected organic compounds containing representative functional groups under standardized conditions(tetrahydrofuran, ) were studied in order to characterize the reducing characteristics of the reagent for selective reductions. The reducing ability of STDEA was also compared with those of the parent sodium aluminum hydride (SAH) and lithium tris(diethylamino)aluminum hydride (LTDEA). The reagent appears to be milder than LTDEA. Nevertheless, the reducing action of STDEA is very similar to that observed previously for LTDEA, as is the case of the corresponding parent sodium and lithium aluminum hydrides. STDEA shows a unique reducing characteristics. Thus, benzyl alcohol, phenol and 1-hexanol evolved hydrogen slowly, whereas 3-hexanol and 3-ethyl-3-pentanol, secondary and tertiary alcohols, were essentially inert to STDEA. Primary amine, such as n-hexylamine, evolved only 1 equivalent of hydrogen slowly. On the other hand, thiols examined were absolutely stable. STDEA reduced aidehydes and ketones rapidly to the corresponding alcohols. The stereoselectivity in the reduction of cyclic ketones by STDEA was similar to that by LTDEA. Quinones, such as p-benzoquinone and anthraquinone, were reduced to the corresponding 1,4-dihydroxycyclohexadienes without evolution of hydrogen. Carboxylic acids and anhydrides were reduced very slowly, whereas acid chlorides were reduced to the corresponding alcohols readily. Esters and epoxides were also reduced readily. Primary carboxamides consumed hydrides for reduction slowly with concurrent hydrogen evolution, but tertiary amides were readily reduced to the corresponding tertiary amines. The rate of reduction of aromatic nitriles was much faster than that of aliphatic nitriles. Nitrogen compounds examined were also reduced slowly. Finally, disulfide, sulfoxide, sulfone, and cyclohexyl tosylate were readily reduced without evolution of hydrogen. In addition to that, the reagent appears to be an excellent partial reducing agent: like LTDEA, STDEA converted ester and primary carboxamides to the corresponding aldehydes in good yields. Furthermore, the reagent reduced aromatic nitriles to the corresponding aldehydes chemoselectively in the presence of aliphatic nitriles. Consequently, STDEA can replace LTDEA effectively, with a higher selectivity, in most organic reductions.
Frequency-domain modeling of continuous-time systems using the lattice algorithms (1989)

Two frequency-domain methods for modeling continuous-time system using the lattice algorithms are presented. In one of the methods, the frequency-domain data are sampled at a nonuniformly spaced frequency grid. This method is suitable for applications where the frequency response of the continuous-time systems can be measured explicitly. In the other method, the frequency-domain data are sampled at a uniformly spaced frequency grid. This method is suitable for applications where the frequency spectrum of the input and output signals are computed from the input and output time-domain data using the FFT (fast Fourier transform).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Designs of broadband and wide-view patterned polarizers for stereoscopic 3D displays (2010)

This work presents a new methodology to design patterned circular polarizers consisting of in-cell polarizers, in-cell retarders and biaxial films to achieve very wide viewing freedom for stereoscopic 3D color LCDs. The biaxial films with least materials and simple fabrication concepts are employed for off-axis compensation of the in-cell retarders. In the best result, the crosstalk ratio is less than 0.035 or 0.0082 respectively for over ± 60° or ± 40° viewing cone of the 3D display. As to the normal view of the proposed structure with glasses or LCD rotation, the crosstalk ratio is less than 0.11%, with 93.5% improvement as compared with the ± λ/4 patterned polarizer. The dispersion properties of materials have been considered in all simulations to mimic real situations.
Time-Sensitive Network (TSN) Experiment in Sensor-Based Integrated Environment for Autonomous Driving (2019)

Recently, large amounts of data traffic from various sensors and image and navigation systems within vehicles are generated for autonomous driving. Broadband communication networks within vehicles have become necessary. New autonomous Ethernet networks are being considered as alternatives. The Ethernet-based in-vehicle network has been standardized in the IEEE 802.1 time-sensitive network (TSN) group since 2006. The Ethernet TSN will be revised and integrated into a subsequent version of IEEE 802.1Q-2018 published in 2018 when various new TSN-related standards are being newly revised and published. A TSN integrated environment simulator is developed in this paper to implement the main functions of the TSN standards that are being developed. This effort would minimize the performance gaps that can occur when the functions of these standards operate in an integrated environment. As part of this purpose, we analyzed the simulator to verify that the traffic for autonomous driving satisfies the TSN transmission requirements in the in-vehicle network (IVN) and the preemption (which is one of the main TSN functions) and reduces the overall End-to-End delay. An optimal guard band size for the preemption was also found for autonomous vehicles in our work. Finally, an IVN model for autonomous vehicles was designed and the performance test was conducted by configuring the traffic to be used for various sensors and electronic control units (ECUs).
Development of Vaccines against Visceral Leishmaniasis (2011)

Leishmaniasis is a neglected disease resulting in a global morbidity of 2,090 thousand Disability-Adjusted Life Years and a mortality rate of approximately 60,000 per year. Among the three clinical forms of leishmaniasis (cutaneous, mucosal, and visceral), visceral leishmaniasis (VL) accounts for the majority of mortality, as if left untreated VL is almost always fatal. Caused by infection with Leishmania donovani or L. infantum, VL represents a serious public health problem in endemic regions and is rapidly emerging as an opportunistic infection in HIV patients. To date, no vaccine exists for VL or any other form of leishmaniasis. In endemic areas, the majority of those infected do not develop clinical symptoms and past infection leads to robust immunity against reinfection. Thus the development of vaccine for Leishmania is a realistic public health goal, and this paper summarizes advances in vaccination strategies against VL.
Improving the Robustness of Private Information Retrieval (2007)

Since 1995, much work has been done creating protocols for private information retrieval (PIR). Many variants of the basic PIR model have been proposed, including such modifications as computational vs. information-theoretic privacy protection, correctness in the face of servers that fail to respond or that respond incorrectly, and protection of sensitive data against the database servers themselves. In this paper, we improve on the robustness of PIR in a number of ways. First, we present a Byzantine-robust PIR protocol which provides information-theoretic privacy protection against coalitions of up to all but one of the responding servers, improving the previous result by a factor of 3. In addition, our protocol allows for more of the responding servers to return incorrect information while still enabling the user to compute the correct result. We then extend our protocol so that queries have information-theoretic protection if a limited number of servers collude, as before, but still retain computational protection if they all collude. We also extend the protocol to provide information-theoretic protection to the contents of the database against collusions of limited numbers of the database servers, at no additional communication cost or increase in the number of servers. All of our protocols retrieve a block of data with communication cost only O(lscr) times the size of the block, where lscr is the number of servers. Finally, we discuss our implementation of these protocols, and measure their performance in order to determine their practicality.
Fullerenes more complex than previously thought (1991)

RETURN TO ISSUEPREVNewsNEXTFullerenes more complex than previously thoughtRUDY BAUMCite this: Chem. Eng. News 1991, 69, 42, 5–6Publication Date (Print):October 21, 1991Publication History Published online10 November 2010Published inissue 21 October 1991https://pubs.acs.org/doi/10.1021/cen-v069n042.p005ahttps://doi.org/10.1021/cen-v069n042.p005anewsACS PublicationsCopyright © 1991 American Chemical SocietyArticle Views8Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Carbon nanomaterials,Nanospheres Get e-Alerts