gebhart/patrepeval huggingface dataset:
Structure, Stereochemistry, and Biological Activity of Integramycin, a Novel Hexacyclic Natural Product Produced by <i>Actinoplanes</i> sp. that Inhibits HIV-1 Integrase (2002)

[structure: see text] HIV-1 integrase is a critical enzyme for viral replication, and its inhibition is an emerging target for potential antiviral chemotherapy. We have discovered a novel inhibitor, integramycin, from screening of fermentation extracts using an in vitro assay. Integramycin possesses a hexacyclic ring system and exhibited an IC50 value of 4 microM against HIV-1 integrase (strand transfer). The isolation, structure elucidation, stereochemistry, conformation, and biological activity has been described.
Strategies to yield water dispersible ZnO NPs synthesized by an organometallic approach (2010)

Le nombre d'études sur la synthèse et l'application de matériaux semi-conducteurs a augmente au cours des dernières années dû à la dépendance de propriétés physiques et chimiques de ces matériaux avec la taille. Plusieurs applications ont émergées, notamment dans les domaines de la biomédecine, les cellules solaires ou de l'électronique. Parmi les matériaux semi-conducteurs connus, ZnO nanométrique est un bon candidat pour ces applications car il est relativement peu coûteux et respectueux avec l'environnement. Des méthodes physiques et chimiques permettant la production de nanostructures de ZnO ont été décrites dans la littérature. Certaines applications des nanoparticules de ZnO nécessitent des solutions colloïdales et de ce point de vue, les méthodes chimiques sont avantageuses. Dans notre groupe de recherche, une méthode chimique basée sur la décomposition de précurseurs organométalliques en présence d'un agent de stabilisation a été développée. Cependant, cette stratégie ne permet la production de nanoparticules de ZnO uniquement solubles dans les solvants apolaires. Les applications en cosmétiques ou en biomédecine ne sont alors pas possibles. Le but de cette thèse est la modification de la synthèse organométallique pour atteindre des nanoparticules de ZnO solubles dans l'eau: soit par modification des particules synthétisées ou par modifications de la procédure synthèse initiale.
Fluorescence topography in biology. III: Characteristic deviations of tryptophan fluorescence in sera of patients with gynecological tumors. (1986)

Abstract The near-ultraviolet region of the total fluorescence (excitation-emission matrix) of human serum reflects essentially the fluorescence of protein-bound tryptophan. We examined topographically the tryptophan fluorescence of human serum. In comparison with fluorescence topograms from sera of healthy donors, sera of patients with gynecological malignancies showed significantly different patterns of tryptophan fluorescence, the major deviations being at 325 and 365 nm. In healthy donors, the tryptophan fluorescence intensity at 365 nm, expressed as percent of the maximum fluorescence intensity (i.e., at 337 nm) varied little, but was markedly lower for sera from patients with malignancies. We found no clear correlation between the extent of the fluorescence deviations and the relative concentration of the protein fractions as determined by electrophoresis. Furthermore, we could rule out inflammation in tumor patients as an explanation for this effect.
Mechanisms of pain and their therapeutic implications (2001)

P ain is an everyday occurrence for humans and other animals, helping to protect against injury, but for some it is also a continuous relentless crippling sensory experience that causes suffering and distress. ] Veterinarians may not provide optimal analgesic therapy because of lack of familiarity with current therapeutic strategies, concerns regarding the potential for the development of drug-induced adverse effects (eg, anorexia and signs of depression) or toxicity (eg, gastric ulcers and liver or renal failure), and the need to comply with federally mandated regulations. Furthermore, pain may be considered to be temporary, secondary to a primary disease, or, if treated, may impose an economic burden (eg, swine castration). Comprehensive clinical data regarding the incidence, prevalence, and severity of pain in animals with naturally occurring diseases are quite sparse, making it difficult to identify target groups, prescribe or evaluate therapies, or provide guidelines for the optimization of wellness programs. 1] The approach uses objective behavioral analysis software that analyzes the frequency and duration of the animal' s position, posture, and specific activity within a confined space. This analysis in conjunction with select speciesspecific behaviors has promise for estimating the sever-
Elastic Buckling of Infinitely Long Specially Orthotropic Plates on Tensionless Foundations (1991)

The results of an analytical study on the elastic buckling of long narrow orthotropic plates resting on a tensionless foundation are reported. The motivation for the present study stems from the importance of delamination buckling as a viable mode of failure in fibrous laminated composites. When near surface delaminations undergo buckling, the buckled displacements are of one sign, because the remainder of the laminate (parent sublaminate) essentially acts like a rigid foundation. The results of the present study can be incorporated into developing delamination growth models for various loading conditions. Example results are presented for five different types of plates where one is of the isotropic type and the remaining four are of the laminated orthotropic type. Example results for two types of Graphite/Epoxy material systems (IM7/8551-7 and T300/BP907) are reported. In the laminates considered, the stacking is sequenced so that the bending constitutive constants D16 and D26 vanish. Extensive parametric analysis was performed and it was found that for the case of a simply supported plate and in the limiting case of a rigid foundation, conforming to buckled displacements of one sign, the increase in the buckling load over that of a simply supported plate but with no foundation varies between 22 and 33 percent, depending on the plate stacking sequence. On the other hand, for the clamped-free case this number was found to vary between 24 and 36 percent for all types of materials used in this study. Previous studies that addressed similar issues did not pay particular attention to the one sided buckling constraint that is placed due to physical considerations.
Synthesis of 1‐Substituted‐phytosphingosine: Novel Protection of Phytosphingosine. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Group‐level variations in motor representation areas of thenar and anterior tibial muscles: Navigated Transcranial Magnetic Stimulation Study (2010)

Navigated transcranial magnetic stimulation (TMS) can be used to stimulate functional cortical areas at precise anatomical location to induce measurable responses. The stimulation has commonly been focused on anatomically predefined motor areas: TMS of that area elicits a measurable muscle response, the motor evoked potential. In clinical pathologies, however, the well-known homunculus somatotopy theory may not be straightforward, and the representation area of the muscle is not fixed. Traditionally, the anatomical locations of TMS stimulations have not been reported at the group level in standard space. This study describes a methodology for group-level analysis by investigating the normal representation areas of thenar and anterior tibial muscle in the primary motor cortex. The optimal representation area for these muscles was mapped in 59 healthy right-handed subjects using navigated TMS. The coordinates of the optimal stimulation sites were then normalized into standard space to determine the representation areas of these muscles at the group-level in healthy subjects. Furthermore, 95% confidence interval ellipsoids were fitted into the optimal stimulation site clusters to define the variation between subjects in optimal stimulation sites. The variation was found to be highest in the anteroposterior direction along the superior margin of the precentral gyrus. These results provide important normative information for clinical studies assessing changes in the functional cortical areas because of plasticity of the brain. Furthermore, it is proposed that the presented methodology to study TMS locations at the group level on standard space will be a suitable tool for research purposes in population studies.
[Urothelial tumors of the bladder]. (1998)

Bladder cancer is a common malignancy and accounts for 8,000 new cases and 4,000 deaths each year in France. Numerous factors may be responsible for the development of this disease, first of which are smoking and occupational exposure to chemicals. Main data regarding etiology, epidemiology and biology of bladder cancer are detailed. Diagnostic and therapeutic advances as well as actual research directions are presented.
ChemInform Abstract: Enantioselective Synthesis of 2‐Hydroxy‐1‐indanone, a Key Precursor of Enantiomerically Pure 1‐Amino‐2‐indanol. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Coupling between minimum scattering antennas (1974)

Coupling between minimum scattering antennas (MSA's) is investigated by the coupling theory developed by Wasylkiwskyj and Kahn. Only rotationally symmetric power patterns are considered, and graphs of relative mutual impedance are presented as a function of distance and pattern parameters. Crossed-dipoles and helices are considered in order to establish a correspondence with simple antenna structures.
Design considerations for achieving ZVS in a half bridge inverter that drives a piezoelectric transformer with no series inductor (2003)

A general procedure for maintaining soft switching in inductor-less half-bridge piezoelectric transformer (PT) inverter was analyzed by applying the equivalent circuit of the PT device. Soft switching capability of the PT was delineated and detailed guidelines are given for the load and frequency boundaries, voltage transfer function and the output voltage that will keep the operation under ZVS conditions. The analysis takes into account the maximum power dissipation of the PT, which is used to bind the permissible power transfer through the device. The analytical results for the half-bridge inductor-less PT inverter were verified by simulation and experiments for a radial vibration mode PT.
ChemInform Abstract: Synthesis and Antitumor Activity of a New Class of Pyrazolo(4,3‐e) pyrrolo(1,2‐a)(1,4)diazepinone Analogs of Pyrrolo(1,4)benzodiazepines ( PBDs). (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electrical Double-Layer Capacitance of Zeolite-Templated Carbon in Organic Electrolyte (2008)

Porous carbon materials have been prepared using chemical vapor deposition of ethylene and acetonitrile on zeolite Y templates with the subsequent removal of the template. The use of zeolite templates enabled tuning of the carbon chemistry, microstructure, and specific surface area while maintaining ordered pores and similar pore-size distribution. Evaluation of the performance of the templated carbons in electrochemical capacitors with tetraethylammonium tetrafluoroborate salt solution in acetonitrile showed a high gravimetric capacitance of up to and a short time constant of up to , indicating fast charge/discharge capability. Nitrogen doping limited the capacitor performance at high current densities without enhancing the energy-storage characteristics at low current densities. Specific capacitance at a constant pore size was found to linearly depend on the surface area, suggesting a potential for further improvements. Carbons produced by zeolite-templating method are promising for use in high-energy, high-power electrochemical capacitors employing organic electrolytes.
Linear and Nonlinear Optical Properties of the Thiophene/Phenylene-Based Oligomer and Polymer (2011)

In this article, we investigate the linear and nonlinear optical properties of the thiophene/phenylene-based oligomer (SL128G) and polymer (FSE59) chemically modified with alquilic chains, which allow greater solubility and provide new optical properties. These compounds present a strong absorption in the UV-visible region, providing a wide transparence window in visible-IR, ideal for applications in nonlinear optics. Employing the Z-scan technique with femtosecond pulses, we show that these compounds exhibit considerable two-photon absorption (2PA), with two 2PA allowed states located at 650 and 800 nm for SL128G and 780 and 920 nm for FSE59. Moreover, we observe the resonance enhancement effect as the excitation wavelength approaches the lowest one-photon-allowed state. By modeling the 2PA spectra considering a four-energy-level diagram within of the sum-over-essential states approach, we obtained the spectroscopic parameters of the electronic transitions to low-energy singlet excited states. Additionally, photoluminescence excited by femtosecond and picosecond pulses were performed to confirm the order of the multiphoton process and estimate the fluorescence lifetime, respectively.
Pentacoordinated molecules. 54. Hydrolysis pathway leading to the formation of novel oxo- and halo-bridged tin(IV) ladder compounds. The molecular structure of the dimeric distannoxanes [Ph2(Cl)SnOSnPh2(OH)]2.cntdot.2Me2CO and [Ph2(Cl)SnOSnPh2(Cl)]2 (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPentacoordinated molecules. 54. Hydrolysis pathway leading to the formation of novel oxo- and halo-bridged tin(IV) ladder compounds. The molecular structure of the dimeric distannoxanes [Ph2(Cl)SnOSnPh2(OH)]2.cntdot.2Me2CO and [Ph2(Cl)SnOSnPh2(Cl)]2Jean F. Vollano, Roberta O. Day, and Robert R. HolmesCite this: Organometallics 1984, 3, 5, 745–750Publication Date (Print):May 1, 1984Publication History Published online1 May 2002Published inissue 1 May 1984https://pubs.acs.org/doi/10.1021/om00083a017https://doi.org/10.1021/om00083a017research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Large-scale parameter extraction in electrocardiology models through Born approximation (2012)

One of the main objectives in electrocardiology is to extract physical properties of cardiac tissues from measured information on electrical activity of the heart. Mathematically, this is an inverse problem for reconstructing coefficients in electrocardiology models from partial knowledge of the solutions of the models. In this work, we consider such parameter extraction problems for two well-studied electrocardiology models: the bidomain model and the FitzHugh-Nagumo model. We propose a systematic reconstruction method based on the Born approximation of the original nonlinear inverse problem. We describe a two-step procedure that allows us to reconstruct not only perturbations of the unknowns, but also the backgrounds around which the linearization is performed. We show some numerical simulations under various conditions to demonstrate the performance of our method. We also introduce a parameterization strategy using eigenfunctions of the Laplacian operator to reduce the number of unknowns in the parameter extraction problem. © 2013 IOP Publishing Ltd.
ChemInform Abstract: Highly Diastereoselective 5‐Hexenyl Radical Cyclizations with Lewis Acids and Carbohydrate Scaffolds. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synergistic therapy by acyclovir and A1110U for mice orofacially infected with herpes simplex viruses (1989)

Clinical effects of the administration of a combination of acyclovir (ACV) and compound A1110U (a 2-acetylpyridine thiocarbonothiohydrazone inactivator of herpes simplex virus [HSV] ribonucleotide reductase) on the development of herpetic skin lesions were studied in athymic and hairless mice infected intracutaneously with different HSV type 1 (HSV-1) strains. ACV was administered topically (5%) or orally (5 mg/ml), while A1110U was applied topically (3%). In all but one experiment, the effect of combination therapy was greater than that calculated for the sum of the individual drug effects in limiting the development of herpetic skin lesions in mice. In several experiments, combination therapy totally eliminated all signs of infection. This synergistic chemotherapeutic efficacy was evident in infections caused by ACV-susceptible as well as several ACV-resistant HSV-1 strains. These results indicate that this combination therapy may provide a significant improvement in clinical responses over single-agent topical therapy.
Why GOMS? (1995)

article Free Access Share on Why GOMS? Author: Bonnie John Human-Computer Interaction Institute and Departments of Computer Science and Psychology, Carnegie Mellon University Human-Computer Interaction Institute and Departments of Computer Science and Psychology, Carnegie Mellon UniversityView Profile Authors Info & Claims InteractionsVolume 2Issue 4Oct. 1995 pp 80–89https://doi.org/10.1145/225362.225374Published:01 October 1995Publication History 36citation3,051DownloadsMetricsTotal Citations36Total Downloads3,051Last 12 Months185Last 6 weeks25 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Should colorectal cancer screening guidelines account for gender and race/ethnicity? (2004)

1022 Objectives: The recommended age to begin colorectal screening is 50 for all Americans at “average” risk, regardless of gender or race/ethnicity. However, the natural history of colorectal cancer differs between men and women and across major racial/ethnic groups. Therefore the optimum starting age for colorectal screening may depend upon gender and race/ethnicity. We compare the total cost-effectiveness of different starting ages for colorectal screening by gender and race/ethnicity to address this issue. Methods: We determined age-specific colorectal cancer incidence rates, the proportion of left-sided cancers, and the proportion of localized cancers in Asian, Black, Latino, and White men and women using the California Cancer Registry. We incorporated these data and available data for life expectancy and colorectal cancer survival to model the cost-effectiveness of two 35-year colorectal cancer-screening interventions. Results: Age-specific colorectal cancer incidence rates were highest in Black men and lowest in Latino women. Screening beginning at age 50 was most cost-effective in Black men and least cost-effective in Latino women (measured as dollars spent per year of life saved) using annual fecal occult blood testing combined with flexible sigmoidoscopy every 5 years and using colonoscopy every 10 years. The cost-effectiveness of a 35-year screening program in Black men beginning at age 45 was similar to the cost-effectiveness of screening White men and Black women beginning at age 50 and more cost-effective than screening non-Black women as well as Asian and Latino men beginning at age 50. Conclusions: Screening is most cost-effective in Black men because of high age-specific colorectal cancer incidence rates. Initiation of colorectal cancer screening in this group prior to age 50 should be strongly considered, and could mimic prostate cancer screening recommendations in this high-risk group. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pfizer
Techniques for high-performance computational steering (1999)

Computational steering lets researchers investigate, calibrate and control long-running, resource-intensive applications at run-time. Magellan, a prototype computational steering system, uses a domain-specific language called ACSL to intelligently control multi-threaded asynchronous steering servers that cooperatively steer applications.
Indication for using high ligation of the inferior mesenteric artery in rectal cancer surgery (1998)

Although the five-year survival rate in patients with inferior mesenteric artery root nodal metastases was lower than in those without metastases, inferior mesenteric artery root nodal dissection should be performed after high ligation of the inferior mesenteric artery for patients with pT3 and pT4 cancers.
Conjugation with Receptor-Targeted Histidine-Rich Peptides Enhances the Pharmacological Effectiveness of Antisense Oligonucleotides (2013)

Ineffective delivery to intracellular sites of action is one of the key limitations to the use of antisense and siRNA oligonucleotides as therapeutic agents. Here, we describe molecular scale antisense oligonucleotide conjugates that bind selectively to a cell surface receptor, are internalized, and then partially escape from nonproductive endosomal locations to reach their sites of action in the nucleus. Peptides that include bombesin sequences for receptor targeting and a run of histidine residues for endosomal disruption were covalently linked to a splice switching antisense oligonucleotide. The conjugates were tested for their ability to correct splicing and up-regulate expression of a luciferase reporter in prostate cancer cells that express the bombesin receptor. We found that trivalent conjugates that included both the targeting sequence and several histidine residues were substantially more effective than conjugates containing only the bombesin or histidine moieties. This demonstrates the potential of creating molecular scale oligonucleotide conjugates with both targeting and endosome escape capabilities.