gebhart/patrepeval huggingface dataset:
Albumin as a prognostic factor for overall survival in newly diagnosed patients with acute myeloid leukemia (AML). (2012)

6586 Background: Hypoalbuminemia (HA) is an adverse prognostic factor in multiple neoplastic diseases. Severe hypoalbuminemia (<3.0 g/dl) at day +90 post allogeneic hematopoietic cell transplant (AHCT) was reported as an independent predictive variable for non-relapse mortality and overall survival (Kharfan-Dabaja, et al Biol Blood Marrow Transplant 2009; 15). We examined the prognostic value of serum albumin level prior to induction chemotherapy in patients with newly diagnosed AML. Methods: Data were collected retrospectively in newly diagnosed AML patients receiving induction chemotherapy (3+ 7 regimen). Primary objective was to examine the relationship between serum albumin at baseline and probability of achieving complete remission (CR) or incomplete remission (CRi) and overall survival (OS). The Kaplan–Meier method used to estimate median overall survival; chi-square test used for comparison of categorical variables and t-test for continuous variables. Log rank test used to compare Kaplan–Meier survival estimates between two groups. Results: Between November 2004 to July 2007, 135 patients who received 3+7 induction chemotherapy were included. Patient baseline characteristics were similar between patients with serum albumin < 3.5 g/dl (HA) and those with serum albumin ≥ 3.5 g/dl (no HA) with respect to age, sex, FAB subtype, history of antecedent MDS, karyotype, and chemotherapy . In patients with HA, mean age was 60 years compared to 56.5 years in non HA group. The median OS for patients with HA was 221 days (95%CI 149.5-292.5) compared to 421 days (95%CI 236.7-605) with normal serum albumin (p<0.005). (Figure-1) The CR/CRi rate was 64%% for HA and 77.6% for those with normal albumin (p=0.09). In a multivariable Cox regression analysis including age ≥ 60 years, history of MDS, karyotype, and serum albumin level at baseline; only age, karyotype and serum albumin were independent predictors of OS [Hazard ratio 0.47 (95%CI 0.31-0.71) (p<0.005) for normal serum albumin group]. Conclusions: In newly diagnosed AML, we demonstrate that hypoalbuminemia < 3.5 g/dl is an independent covariate for overall survival with conventional chemotherapy management. The prognostic value of low serum albumin should be validated in a prospective study.
ChemInform Abstract: Synthesis of Biphenyls Mimicking the Structure of the Antimitotic Rhazinilam. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Corrosion Rate of Buried Pipeline by Induced Alternating Current (2001)

An alternating current (AC) corrosion using coupon and electric resistance (ER) probe has been studied. Coupon coupled with ER probe were applied in terms of AC voltage from high value to low value through the survey of AC voltages on buried gas transmission pipeline over the country. Parameters such as AC current density of coupon, AC voltage, cathodic protection potential, soil resistivity and frequency were monitored continually. Corrosion induced by AC was observed even under cathodically protected condition that met cathodic protection criterion (below -850mv vs. CSE). Corrosion rate was affected mainly not by AC voltage but by both of frequency and AC current density. An experimental corrosion rate relationship could be obtained statistically, In which AC corrosion rate increased linearly with effective AC current density and its slope was 0.619 in case of coupon and 0.885 in case of ER probe.
Synthetic approaches to some naturally occurring phenalenones and related compounds: synthesis of 3,4,6,9-tetrahydroxy-7-methylphenalenone (1968)

B. W. Bycroft and A. J. Eglington, Chem. Commun. (London), 1968, 72 DOI: 10.1039/C19680000072
Clinical parameters that predict histology of postchemotherapy retroperitoneal lymph node mass in testicular cancer (2004)

Both postchemotherapy RPLN mass size and pretreatment tumor marker levels are possible predictors for necrosis of the residual mass in testicular cancer patients.
Corrected Genome Annotations Reveal Gene Loss and Antibiotic Resistance as Drivers in the Fitness Evolution of Salmonella enterica Serovar Typhimurium (2016)

Significant discrepancies in the annotations of bacterial genomes could mislead the conclusions about evolutionary origin of chromosomal genes, as we demonstrate here via a cross-annotation-based analysis of Salmonella Typhimurium genomes from GenBank. We conclude that despite being able to infect a broad range of vertebrate hosts, the genomic diversity of S Typhimurium strains is almost exclusively limited to gene loss and the transfer of prophage DNA. Only nonphage chromosomal genes acquired after the emergence of the serovar are linked to the genomic islands harboring multidrug resistance factors. Since the fitness factors could lead to increased virulence, this poses an important research question: could overuse or misuse of antimicrobials act as selection forces for the emergence of more pathogenic strains of Salmonella?
Improving the thermal performance of the transparent building envelope: finite element analysis of possible techniques to reduce the U-value of the glassblocks (2012)

U-value of glazed elements is often a critical issue because these components, due to their small thickness and to the poor resistance of the glass and frame materials, cause very relevant heat fluxes. This paper presents an investigation on the thermal properties of a particular glazed component: the glassblock. Generally standard glassblocks have high Uvalues in comparison to the maximum values allowed by energy efficiency standards for glazed surfaces. This paper reports a summary of possible solutions that could improve the performances of the glassblock. A set of new configurations of the glassblock has been defined by schematic models and their overall thermal resistance has been assessed by the means of Finite Element software. The resulting performances are presented in terms of the global thermal transmittance of the modified glassblocks, also considering the effects of sealing and mortar. The paper also shows some significant potential improvements to address new production lines.
The Mathematics of Thermal Modeling (2001)

The use of lasers for various applications in materials processing has grown rapidly in recent years. Lasers are by nature particularly well suited to automation, but to ensure repeatability and reliability, the engineers employing them must not simply rely on numerical analysis software. They must have a firm grasp on the physical principles invol
Functional Simian Virus 40 T Antigen Is Expressed in Hybrid Cells Having Finite Proliferative Potential (1987)

Simian virus 40-transformed human cells fused with other independently derived simian virus 40-transformed cells and tumor-derived cells containing activated H-ras and N-ras oncogenes yielded hybrids capable of indefinite division. Fusions with various other immortal cells yielded hybrids that had limited division potential. T antigen expressed in limited-division hybrids was functional for the induction of cellular DNA synthesis.
Time-Resolved Dehydration-Induced Structural Changes in an Intact Bovine Cortical Bone Revealed by Solid-State NMR Spectroscopy (2009)

Understanding the structure and structural changes of bone, a highly heterogeneous material with a complex hierarchical architecture, continues to be a significant challenge even for high-resolution solid-state NMR spectroscopy. While it is known that dehydration affects mechanical properties of bone by decreasing its strength and toughness, the underlying structural mechanism at the atomic level is unknown. Solid-state NMR spectroscopy, controlled dehydration, and H/D exchange were used for the first time to reveal the structural changes of an intact piece of bovine cortical bone. (1)H spectra were used to monitor the dehydration of the bone inside the rotor, and high-resolution (13)C chemical shift spectra obtained under magic-angle spinning were used evaluate the dehydration-induced conformational changes in the bone. The experiments revealed the slow denaturation of collagen due to dehydration while the trans-Xaa-Pro conformation in collagen remained unchanged. Our results suggest that glycosaminoglycans in the collagen fiber and mineral interface may chelate with a Ca(2+) ion present on the surface of the mineral through sulfate or carboxylate groups. These results provide insights into the role of water molecules in the bone structure and shed light on the relationship between the structure and mechanics of bone.
Metallorganische Chemische Gasphasenabscheidung (MOCVD) ferroelektrischer Dünnschichten: Herstellung und Charakterisierung (2007)

mit dem Steuerungssystem, den Bubblern, dem Verdampfer, dem Reaktor und der Khlfalle.Die Vakuumpumpe befindet sich hinter der rckwrtigen Wand.Abbildung 3.2.: Ein Prekursorflssigkeitsbehlter (Bubbler ), Foto (links) und schematische Zeichnung (rechts).In diesem Aufbau wird der gelste Prekursor durch Druckbeaufschlagung mit Ar aus dem Bubbler befrdert.Abbildung 4.7.: Arrhenius-Auftragung der Dicke von PbO-Schichten aus dem Prekursor Pb(TMOD) 2 0,1 mol/l in Butylacetat.Die Oxidationsgase waren jeweils 100 sccm O 2 und N 2 O, die Verdampfertemperatur betrug 230 .Abbildung 4.8.: Rntgenbeugungsdiagramme von PbO-Dnnschichten aus dem Prekursor Pb(TMOD) 2 bei 500, 550, 600 und 650 (von unten nach oben).Auerdem ist auch der Substratpeak Pt (111) zu sehen.Die Verdampfertemperatur betrug 230 .Abbildung 4.9.: Arrhenius-Auftragung der Dicke von PbO-Schichten aus dem Prekursor Pb(DPM) 2 0,1 mol/l in Butylacetat.Das Oxidationsgas war 200 sccm O 2 , die Verdampfertemperatur betrug 220 .Als gepunktete Linie sind zum Vergleich die Werte von Pb(TMOD) 2 eingetragen.Abbildung 4.10.: Rntgenbeugungsdiagramme von PbO-Dnnschichten aus dem Prekursor Pb(DPM) 2 bei 500, 550, 600, 650 und 700 (von unten nach oben).Auerdem sind die Substratpeaks Si (200) und Pt (111) zu sehen.Die Verdampfertemperatur betrug 220 .Abbildung 5.1.:Bild einer hochauflsenden Transmissionselektronenmikroskopie (HR-TEM) der polykristallinen PZT(30/70)-Schicht auf Ir.Man erkennt gut drei bereinanderliegende Bereiche.Abbildung 5.2.: Rntgenbeugungsdiagramm einer polykristallinen PZT(30/70)-Schicht mit (100)-Vorzugsorientierung auf Ir.Abbildung 5.3.
I. Basic and applied S-layer research: an overview (1997)

S-layers are crystalline monomolecular assemblies of protein or glycoprotein, which represent one of the most common cell surface structures in Archaea and Bacteria. As porous lattices completely covering the cell surface they can provide prokaryotic cells with selection advantages by functioning as protective coats, as structures involved in cell adhesion and surface recognition, as molecule or ion traps, and molecular sieves. In Archaea, which possess S-layers as exclusive cell wall component, the (glyco)protein lattices function as cell shape determining/maintaining framework. Studies on structure, chemistry, genetics, assembly and function of S-layers revealed a considerable application potential for the regular arrays in biotechnology, biomimetics, biomedicine and molecular nanotechnology.
Allelic imbalance on chromosomes 13 and 17 and mutation analysis of BRCA1 and BRCA2 genes in monozygotic twins concordant for breast cancer (2001)

To study genetic changes associated with the development of breast cancer and the extent of its hereditary predisposition, paraffin-embedded tissue samples were obtained from monozygotic twin pairs concordant for breast cancer through the linked Swedish Twin and Cancer Registries. DNA samples extracted from the matched tumour and normal tissues of nine twin pairs were analysed for allelic imbalance using a series of microsatellite markers on chromosomes 13 and 17, containing loci with known tumour suppressor genes. Multiple losses of constitutional heterozygosity (LOH), consistent with a loss of large genomic region, the whole chromosome or chromosome arm, was found in at least three pairs of twins. One double mitotic crossover was identified in one tumour sample in a pair concordant for LOH at multiple loci on both chromosomes. Recombination breakpoints were mapped to regions delineated by D13S218 and D13S263, and D13S155 and D13S279, respectively. In general, no genetic effect of losing the same allele within a twin pair was found. However, for one marker at chromosome 13 (D13S328, between the BRCA2 and the RB-1 loci) and two markers on chromosome 17 (D17S786, distal to the p53 locus, and D17S855, an intragenic BRCA1 marker) the proportion of twin pairs with the same LOH was significantly higher than expected. These regions may reflect hereditary genomic changes in our sample set. In addition, tumour DNA samples from a subset of 12 twin pairs were analysed for BRCA1 and BRCA2 mutations using exon-by-exon single-strand conformation polymorphism analysis. Two unclassified BRCA2 variants, with a putative pathogenic effect, were identified, but no pathogenic alterations were found in the BRCA1 gene.
The future therapeutic potential of histone demethylases: A critical analysis. (2009)

Once regarded as an irreversible modification, the methylation of histone protein tails has recently been highlighted following the identification of enzymes capable of histone demethylation in response to developmental or environmental cues. An awareness of the dynamic nature of histone modification has stimulated interest in the concept that drugs targeting histone methylation/demethylation might provide treatments for cancer, inflammation and metabolic disorders. However, epigenetic therapies that target histone demethylation are at the concept stage. Histone demethylases and their potential as therapeutic targets are discussed in this review.
[Mitogenic activity of vasculotropin for peripheral human lymphocytes]. (1991)

Vasculotropin is a growth factor with a unique specificity for vascular derived endothelial cells. We report that normal human peripheral lymphocytes represent another target for vasculotropin. The mitogenic activity of the medium conditioned by these cells cultured in the presence of Concanavalin A is potentiated by vasculotropin. This effect is exerted more likely through interactions with the soluble mediators rather than through the VAS receptors since VAS binds equally to Concanavalin A stimulated and to unstimulated lymphocytes.
Research Opportunities for Undergraduate Institutions at the NSF Web Site (2000)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResearch Opportunities for Undergraduate Institutions at the NSF Web SiteDonald J. Wink View Author Information Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607Cite this: J. Chem. Educ. 2000, 77, 12, 1549Publication Date (Web):December 1, 2000Publication History Received3 August 2009Published online1 December 2000Published inissue 1 December 2000https://doi.org/10.1021/ed077p1549RIGHTS & PERMISSIONSArticle Views100Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (58 KB) Get e-AlertsSUBJECTS:Students,Undergraduates Get e-Alerts
Structural and magnetic anisotropy of directionally-crystallized ferromagnetic microwires (2018)

Amorphous ferromagnetic microwires have drawn attention primarily due to their excellent soft magnetic properties as the elements of sensors. In this work, semi-hard magnetic microwires of composition Fe 4.3 Co 67.7 Si 11 B 14 Cr 3 were obtained after a process of directional crystallization from amorphous state. The XRD analysis of crushed and whole wires identified the formation of the face-centered Co-modification as the main phase of directionally crystallized core alloy, which explains a large increase in anisotropy and coercivity. The application of a magnetic field during crystallization may orient the easy anisotropy axis of crystallites along the wire. This is confirmed by the investigation of crystallite orientation with respect to the wire axis and X-rays direction in diffractometer. The obtained results revealed that the formation of crystallites in amorphous Co-rich microwires occurs with the predominant orientation of the crystallographic direction [111] along the wire axis and the direction of a magnetic field during the directional crystallization process.
pH Responsiveness of Block Copolymer Vesicles with a Polypeptide Corona (2007)

The aggregation behavior of polybutadiene165-block-poly(L-lysine)88 in saline solution was studied by combined static and dynamic light scattering analyses. Vesicles were observed if the polypeptide segment was in a 100% coil conformation (pH 7.0) or in an 80% alpha-helical conformation (pH 10.3). At the higher pH, aggregates were smaller in size (hydrodynamic radius: 364 nm --> 215 nm) and chains were more densely packed at the core-corona interface (interchain distance: 3.2 nm --> 2.4 nm). Changes in size and structure could be explained in basic terms of colloid stabilization without considering a secondary structure effect.
Monograph of the Mutillidae of North America / (1886)

Eyes small, round; head subglobose, mandibles tridentate in the male, unidentate in the female; wings with one marginal and four submarginal cells; margins of the abdominal segments crenate, tridentate at apex. 8, Myrmosa.Eyes ovate, ocelli placed high on the vertex; antenne filiform, mandibles arcuate in the female; head subglobose ; scape of male antenne very short; wings with one elongate marginal cell which extends nearly to the tip of the wing; three submarginal cells............... 9, Methoca.
Polyethylenimine catalysts containing an isolated apolar binding site: Solvolysis of <i>p</i>‐nitrophenyl esters (1982)

No Abstract.
Speculations regarding the influence of the major histocompatibility complex (H-2) upon congenital craniofacial malformations in inbred and congenic strains of mice. (1979)

Investigations in different mammalian species have demonstrated a remarkable degree of analogy between distant mammalian species. All mammals possess a major histocompatilibity complex. The identified and postulated functions for the MHC appear to be similar among all mammalian species [14, 25]. One fascinating, but still unconfirmed possibility is that the MHC functions to regulate the immunobiology of normal pregnancy. It should be stressed at this point that much more knowledge is necessary to elucidate the mechanism of H-2-disease associations in mice and HLA-disease associations in man [25]. One explanation of the observed H-2 and HLA-disease associations is linkage disequilibrium. Data are available suggesting a tenuous HLA--cleft lip and/or palate association [34, 35] but the data are equivocal. The available data from congenic mice studies are considerably less equivocal and strongly suggest several important future approaches. Identification of the H-2a haplotype susceptibility and the H-2b resistance to steroid-induced clefting is a major advance in this complex field [36]. Available methods are sensitive, and newer, more precise methods are now in the offing. The renaissance in the field of congenital craniofacial malformations is rather exciting, especially the renewed awareness of interdisciplinary research toward ultimate prevention. Understandably, many physicians, dentists, nurses, and pharmacists, as well as allied biomedical health professionals investigating the heredity of congenital craniofacial malformations, are deeply interested in immunogenetics. In tandem, the biomedical scientific community (eg developmental biologists, molecular biologists, immunologists) wish to learn more about the complicated and often overlapping relationships between various clinical features of the diseases concerned. All are aware that our knowledge of this fascinating subject will not stand still; many are busy changing it.
Sampling and Analysis of Phenols in Air (1959)

(1959). Sampling and Analysis of Phenols in Air. American Industrial Hygiene Association Journal: Vol. 20, No. 2, pp. 142-148.
ChemInform Abstract: Lithium 2‐(2‐Lithiomethylphenyl)ethanolate from Isochroman: Easy Preparation of Substituted Benzoxepines and Functionalized Arenes. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Infrared scatterplate interferometry (1980)

Scatterplate inferferometry in the IR (λ = 10.6 μm) is virtually the same as that in the visible except for an appropriate change in optical materials. Techniques for its fabrication and alignment are described. Some of the side effects produced by the pyroelectric vidicon that are peculiar to scatterplate interferometry are discussed.
The Effects of Aldosterone and Spironolactone on Renal Kallikrein in the Rat (1976)

1. A technique has been developed for the measurement of kallikrein 'production' in rat renal cortical cells in suspension. 2. After preparative steps, column chromatography on DEAE-cellulose yielded a peak of alpha-N-tosyl-L-arginine methyl ester (Tos-Arg-OMe) esterase activity identical with kallikrein isolated from rat urine in respect of pH optimum, effects of inhibitors, biological activity and immunological properties. 3. The nutrient medium surrounding incubated cells contained measurable kallikrein activity, which was increased by aldosterone and decreased by spironolactone. 4. The results raised the possibility that kallikrein could be an aldosterone-induced protein.