gebhart/patrepeval huggingface dataset:
Comparative effects of two beta-blockers on cardiovascular reactivity and type A behavior in hypertensives. (1988)

This study compared the effects of beta-blockers differing in degree of central nervous system penetration on Type A behavior and cardiovascular reactivity to mental stress. Forty-six male hypertensives were assigned randomly to receive either highly lipophilic and nonselective propranolol, hydrophilic and cardioselective atenolol, the diuretic hydrochlorothiazide, or placebo. Subjects were administered parallel forms of the Structured Interview (SI) and performed mental arithmetic and a cognitive task prior to and after 6 weeks of therapy. Results indicated that diuretic and placebo subjects (subsequently combined into a single control group) did not differ and that both beta-blockers reduced heart rate but not blood pressure reactivity to mental stress (p less than 0.02), an effect that was strongest during the mental arithmetic test. Analysis of SI components indicated a reduction only in explosive speech for beta-blockers versus controls (p less than 0.05). For global SI classifications, seven out of 12 subjects (58%) receiving propranolol, three of 12 (25%) receiving atenolol, and four of 22 control subjects (18%) became less Type A (p less than 0.05). These data do not replicate results of a prior study obtained with atenolol and suggest that only a subset of hypertensive individuals show reduced Type A behavior with propranolol. Central nervous system mechanisms may be important in producing these effects.
Comparable heavy and light chain pairings in normal and systemic lupus erythematosus IgG+ B cells (2000)

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the presence of high immunoglobulin serum titers, but the mechanism by which these arise remains unclear. It has been suggested that the disease is associated with specific antibody features, including variable gene use, the presence of charged complementarity-determining region residues and/or an aberrant process of secondary light chain rearrangement. To study this in more detail, we compared variable, diversity and joining gene segment use, somatic mutation, and heavy and light chain pairings in single peripheral IgG(+) B cells between one normal (209 B cells) and two SLE (156 B cells) donors. In contrast to others, we found no systematic differences, indicating that the memory B cell repertoires in normal and SLE donors are shaped in a similar way.
Anti-f detected by a low ionic strength polybren method on the auto analyzer only. (1989)

An anti-f antibody found in a Japanese post-operative patient with gastric cancer, aged 65 years, is reported. He had a history of blood transfusion during the operation in October 1984.His serum was found probably to contain IgG and IgM antibodies with anti-f specifity and anti-I, in May 1985. The anti-f was detected by low ionic strength polybren (LISP) method on the Auto Analyzer (AAII) but not by saline, albumin, bromelin, and indirect antiglobulin technique in a manual.Testing blood from 200 donors by the AAII, his serum agglutinated 16 blood samples (8%) of phenotype CcDee and ccDEe.Anti-f antibody is frequently found as a secondary antibody in most anti-c and anti-e sera, but this case is unique because his serum contains anti-f only.A low ionic strenght polybren method was employed to detect Rh antibody.
Impact Induced Stress Waves in an Anisotropic Plate (1979)

Stress wave propagation in an anisotropic plate due to impact forces has been examined. The plate is modeled as a number of identical anisotropic layers. Mindlin's approximate theory of plates is applied to each layer to obtain a set of difference-differential equations of motion with use of the interlaminar stresses and displacements as explicit variables. Dispersion relationships for harmonic waves are found when traction-free boundary conditions are applied to both surfaces of the plate and appropriate correction factors are found. The difference-differential equations are reduced to difference equations via integral transforms. With given impact boundary conditions, these equations are solved for an arbitrary number of layers in the plate and the transient propagation of stress waves is calculated by means of a Fast Fourier Transform algorithm.
<b>An Efficient Asymmetric Synthesis of 2-Substituted Ferrocenecarboxaldehydes</b> (1997)

Ferrocenecarboxaldehyde is readily transformed into the acetal of (S)-1,2,4-butanetriol (1,3-dioxane structure) and further methylated to give acetal 15. This can then be ortho-lithiated using t-BuLi with very high diastereoselectivity (98% de). Electrophilic quenching provided a large array of compounds of established stereochemistry. Controlled hydrolysis leads to many ortho-substituted ferrocenecarboxaldehydes (98% ee) which themselves are starting materials in the synthesis of various classes of enantiopure ferrocene derivatives with planar chirality of predictable absolute configuration.
Restricted Dietary Sodium Intake Alters Peripheral but Not Central Angiotensin II Receptors (1984)

Male Sprague-Dawley rats were maintained on either a normal or low-sodium diet for 5 weeks to examine whether dietary sodium restriction alters angiotensin II (Ang II) receptors. The receptor sites in the hypothalamus-thalamus-septum (H-T-S) region of the brain, the adrenal glands and bladder visceral smooth muscle were measured by saturation isotherm binding assays using 125I-Ang II. Compared to control rats, the low-sodium diet group showed a smaller weight gain, reduced water intake, elevated hematocrit, and decreased urinary sodium concentration. In addition, sodium-depleted rats had a 10-fold elevation in plasma renin activity. However, neither binding affinity of 125I-Ang II to the brain H-T-S region nor its density was significantly different between the two groups. In contrast, both the 125I-Ang II binding density and dissociation constant in the adrenal gland were significantly elevated, while the binding density of 125-I-Ang II in the bladder smooth muscle was significantly decreased in the sodium-restricted group. These results suggest that dietary sodium depletion does not alter Ang II receptors in the rat brain areas wherein Ang II exerts the majority of its central actions.
Application of Mechanochemistry in Ferrite Materials Technology (1997)

An overview of progress and implications of recent technological advances in mechanochemical processing of ferrites is presented. We discuss the potential for applications of mechanical activation by induced phase transformations and chemical reactions in soft and hard ferrite materials through enhancement of structural and magnetic properties.
MC-MIMO radar: Recoverability and performance bounds (2013)

It was recently shown that low rank matrix completion theory can be employed for designing new sampling schemes in the context of MIMO radars, which can lead to the reduction of the high volume of data typically required for accurate target detection and estimation. This paper focuses on the performance of matrix completion in colocated MIMO radar systems equipped with Uniform Linear Arrays (ULAs). Exploiting the particular structure of the received data matrix, we present novel theoretical results showing that its coherence is both asymptotically and approximately optimal with respect to the number of antennas of the arrays involved and further, that the data matrix is recoverable using a subset of its entries with minimal cardinality.
Quantitative Profiling of Chromatome Dynamics Reveals a Novel Role for HP1BP3 in Hypoxia-induced Oncogenesis (2014)

In contrast to the intensely studied genetic and epigenetic changes that induce host cell transformation to initiate tumor development, those that promote the malignant progression of cancer remain poorly defined. As emerging evidence suggests that the hypoxic tumor microenvironment could re-model the chromatin-associated proteome (chromatome) to induce epigenetic changes and alter gene expression in cancer cells, we hypothesized that hypoxia-driven evolution of the chromatome promotes malignant changes and the development of therapy resistance in tumor cells. To test this hypothesis, we isolated chromatins from tumor cells treated with varying conditions of normoxia, hypoxia, and re-oxygenation and then partially digested them with DNase I and analyzed them for changes in euchromatin- and heterochromatin-associated proteins using an iTRAQ-based quantitative proteomic approach. We identified a total of 1446 proteins with a high level of confidence, including 819 proteins that were observed to change their chromatin association topology under hypoxic conditions. These hypoxia-sensitive proteins included key mediators of chromatin organization, transcriptional regulation, and DNA repair. Furthermore, our proteomic and functional experiments revealed a novel role for the chromatin organizer protein HP1BP3 in mediating chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance, and self-renewal. Taken together, our findings indicate that HP1BP3 is a key mediator of tumor progression and cancer cell acquisition of therapy-resistant traits, and thus might represent a novel therapeutic target in a range of human malignancies.
Assisted Reproduction and Preterm Birth (2012)

that is one of the leading causes for perinatal morbidity and mortality.Moreover, prematurity is a leading cause for neonatal mortality, as well as short and long term morbidity.The incidence of preterm delivery is constantly increasing, crossing the 12% in the USA, and it's annual cost reached 26.2 billion US dollars in 2005, posing a huge burden on public health (Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes, 2007).Prematurity can be either spontaneous due to preterm labor with intact membranes (PTL) or preterm prelabor rupture of the chorioamniotic membranes (preterm PROM); or indicated, meaning induced preterm delivery by the medical team due to maternal (i.e.preeclampsia) or fetal (growth restriction, non-reassuring fetal heart rate tracing) indication (Goldenberg, Culhane et al., 2008).The incidence of the latter group, especially after 34 weeks of gestation, is constantly rising (Ananth, Joseph et al., 2005; Ananth and Vintzileos, 2006a;Ananth, Getahun et al., 2006).Emerging contributors for the increasing rate of preterm birth are assisted reproduction technologies (Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes, 2007).The use of infertility treatments has risen dramatically in the past 20 years; between 1996 and 2003, the number of cycles of Assisted reproductive technologies (ART) nearly doubled from 64,681 to 122,872.The number of live births resulting from conceptions achieved by the use of ARTs more than doubled from 14,507 to 35,785 (Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes, 1980).This has been associated with the trend to delay childbearing, indeed, more than 50 percent of these women were 35 years of age or older.In recent years, an unintended consequence of the use of these technologies, multiple gestations and the increased risk for preterm delivery, has become a focus of attention, and the institute of Medicine in the USA has concluded that "Fertility treatments are a significant contributor to preterm birth among both multiple and singleton pregnancies."(Institute of www.intechopen.com2011).While in Europe, according to the 10th annual European Society of Human Reproduction and Embryology (ESHRE) publication the reported number of ART cycles has increased, with a marginal increase in pregnancy rates, even though fewer embryos were transferred and the multiple delivery rates have declined (1994).This report includes 20 countries, where all clinics report their activity to the IVF register.Altogether, a total of 359,110 cycles were performed in a population of 422.5 million, corresponding to 850 cycles per million inhabitants.The IVF cycles rates of clinical pregnancy per ovum aspiration and per embryo transfer were 29.0 and 32.4%, respectively; while the corresponding ICSI cycles rates were 29.9 and 33.0%, respectively (1994).In spite of the new guidelines, transferring of 2 embryos is still the most prevalent choice in the European Union.
Construction and Economics of a Pilot/Full-Scale Biological Trickling Filter Reactor for the Removal of Volatile Organic Compounds from Polluted Air (2000)

The design and the construction of an actual 8.7-m3 pilot/full-scale biotrickling filter for waste air treatment is described and compared with a previous conceptual scale-up of a laboratory reactor. The reactor construction costs are detailed and show that about one-half of the total reactor costs ($97,000 out of $178,000) was for personnel and engineering time, whereas approximately 20% was for monitoring and control equipment. A detailed treatment cost analysis demonstrated that, for an empty bed contact time of 90 sec, the overall treatment costs (including capital charges) were as low as $8.7/1000 m3air in the case where a nonchlorinated volatile organic compound (VOC) was treated, and $14/1000 m3air for chlorinated compounds such as CH2Cl2. Comparison of these costs with conventional air pollution control techniques demonstrates excellent perspectives for more field applications of biotrickling filters. As the specific costs of building and operating biotrickling filter reactors decrease with increasing size of the reactor, the cost benefit of biotrickling filtration is expected to increase for full technical-scale bioreactors.
High velocity electron injection MOSFETs for ballistic transistors using SiGe/strained-Si heterojunction source structures (2004)

In this study, we have experimentally demonstrated, for the first time, the G/sub m/ enhancement due to higher velocity injection in a MOSFET structure with a source SiGe/strained-Si heterojunction (hetero-MOSFETs), compared to those in strained-SOIs (SSOI) and conventional SOIs. We present the concept and the simulated results of the hetero-source MOSFETs, followed by the process steps and experimental G/sub m/ characteristics.
8,9,10,10a-Tetrahydro-6<i>H</i>-tetrazolo[1,5-<i>a</i>]pyrrolo[2,1-<i>c</i>]pyrazines: New Heterocyclic Frameworks Generated by an Ugi-Type Multicomponent Reaction (2006)

A one-pot, Ugi-type three-component coupling process between an aldehyde, an isocyanide and proline tetrazole is reported, leading to new heterocyclic structures in good to excellent yields.
Natural Killer Cell Frequency and Function in Pigs Selectively Bred for High or Low Antibody and Cell-Mediated Immune Response: Response to Vaccination with Modified Live Transmissible Gastroenteritis Virus (1998)

Porcine NK cells are small to medium lymphocytes which are lytic for tumours and virally infected cells when co-cultured for long periods ( approximately 16 h). The frequency and function of NK cells were examined in generation 8 of pigs genetically selected for high (H), low (L), and control (C) antibody (Ab) and cell-mediated immune response (CMIR). The NK phenotype was identified using a pan-species NK-specific murine monoclonal antibody (5C6) and both binding and lysis of the NK target, K562. Vaccination with modified live transmissible gastroenteritis virus (TGEV) had no effect on blood leucocyte NK cell frequency. In interactions with K562 targets, NK cells of H and C pigs responded similarly in frequency of conjugate formation and lytic activity, while L pigs had very little or no response. Therefore, in pigs selected for high Ab and CMIR, there was no correlated enhancement of NK-cell-related traits following vaccination with TGEV, while selection for low immune response was associated with reduced NK response in pigs. This may suggest that low immune response can reflect reduced contribution of NK cells in pigs.
Phosphatidylinositol 3-Phosphate Induces the Membrane Penetration of the FYVE Domains of Vps27p and Hrs (2002)

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. To elucidate the mechanism by which the FYVE domain interacts with PtdIns(3)P-containing membranes, we measured the membrane binding of the FYVE domains of yeast Vps27p and Drosophila hepatocyte growth factor-regulated tyrosine kinase substrate and their mutants by surface plasmon resonance and monolayer penetration analyses. These measurements as well as electrostatic potential calculation show that PtdIns(3)P specifically induces the membrane penetration of the FYVE domains and increases their membrane residence time by decreasing the positive charge surrounding the hydrophobic tip of the domain and causing local conformational changes. Mutations of hydrophobic residues located close to the PtdIns(3)P-binding pocket or an Arg residue directly involved in PtdIns(3)P binding abrogated the penetration of the FYVE domains into the monolayer, the packing density of which is comparable with that of biological membranes and large unilamellar vesicles. Based on these results, we propose a mechanism of the membrane binding of the FYVE domain in which the domain first binds to the PtdIns(3)P-containing membrane by specific PtdIns(3)P binding and nonspecific electrostatic interactions, which is then followed by the PtdIns(3)P-induced partial membrane penetration of the domain.
The effect of age, pairing, copulation, and 2‐Br‐α‐ergocryptine in the male Mongolian gerbil on the prolactin cells in the anterior pituitary identified by immunocytochemical and Herlant's tetrachrome methods (1984)

Near-adjacent, midsagittal sections of pituitaries of infantile and adult male Mongolian gerbils in several experimental groups (bachelor, paired, tartaric acid-injected, postcopulatory gerbil, and postcopulatory animal injected with 2-bromo-alpha-ergocryptine [CB-154]), were stained by a modification of Herlant's tetrachrome and by the peroxidase-labeled antibody method for prolactin. Cell counts of erythrosinophils and cells immunoreactive for prolactin were made. Sequential staining procedures and thin adjacent sections were used to correlate the staining results. Erythrosinophils were very rare in the infant pituitaries; they increased (P less than .01) in numbers in bachelor pituitaries, remained at the same level (P greater than .05) in paired animals, increased (P less than .01) in the postcopulatory gerbils that were injected with tartaric acid, and increased much less (P less than .05) in postcopulatory males that were injected with CB-154. Prolactin cells were present in modest numbers in infant pituitaries; they increased (P less than .01); in bachelors and reached their highest number in paired animals (P less than .001); they remained unchanged (P greater than .05) in tartaric acid-injected postcopulatory animals but declined (P less than .001) in CB-154-injected, postcopulatory animals. The number of prolactin cells was always significantly greater (P less than .001) than the number of erythrosinophils. Correlative studies revealed the erythrosinophils, some of the light blue cells, and some of the chromophobes gave positive immunocytochemical reactions for prolactin. Apparently, CB-154 inhibited the erythrosinophils and the immunoreactive prolactin cells in the postcopulatory male gerbil, as indicated by a reduction in the number, size, and staining intensity of the cells.
Preconcentration of selenium and antimony from seawater for determination by graphite furnace atomic absorption spectrometry (1985)

NRC publication: Yes
EL ALUMBRADO DE CARRETERA COMO MEDIDA CONTRA ACCIDENTES (2000)

Tras abordar la problematica de los accidentes nocturnos de carretera y el alumbrado como contramedida, en la presente ponencia se procede a realizar un analisis de los factores que influyen en los accidentes nocturnos. Asimismo se expone un estudio sobre el alumbrado como medida contra accidentes y el analisis de los costes y beneficios del alumbrado en carreteras. Se concluye que al considerar la iluminacion de la carretera como una prevencion de los accidentes, y si se elaboran normas de ingenieria apropiadas, se podria reducir los accidentes por la noche cuando la misma se disene, instale y mantenga adecuadamente. Ver ficha general ITRD S405042.
3T-TFET bitcell based TFET-CMOS hybrid SRAM design for Ultra-Low Power applications (2016)

International audience
PPh<sub>3</sub>-Substituted [2,5-Ph<sub>2</sub>-3,4-Tol<sub>2</sub>(η<sup>5</sup>-C<sub>4</sub>COH)]Ru(CO)(PPh<sub>3</sub>)H Exhibits Slower Stoichiometric Reduction, Faster Catalytic Hydrogenation, and Higher Chemoselectivity for Hydrogenation of Aldehydes over Ketones Than the Dicarbonyl Shvo Catalyst (2006)

The PPh3-substituted hydroxycyclopentadienyl ruthenium hydride [2,5-Ph2-3,4-Tol2(η5-C4COH)]Ru(CO)(PPh3)H (1) stoichiometrically reduces aldehydes and ketones in the presence of a pyridine trap to produce alcohols and the ruthenium pyridine complex 5, with a rate law that is dependent only on [aldehyde] and [1]. The observation of deuterium kinetic isotope effects on substitution of the acidic and hydridic protons of 1 are consistent with concerted transfer of hydrogen to aldehydes during reduction. 1 catalytically hydrogenates aldehydes under mild temperature and pressure conditions. While the Shvo catalyst 2 shows little activity under these conditions, it surpasses 1 at elevated temperatures and pressures. 1 shows high chemoselectivity for catalytic hydrogenation of aldehydes over ketones, while 2 is much less selective.
Coded Cooperation for Ad Hoc Networks with Spatial Multiplexing (2007)

In this paper we design a network based on cooperative spatial multiplexing (SM), capable to adaptively support terminals with multiple antennas and multiple cooperating nodes. Our proposal overcomes limitations of existing cooperative networks based on space-time block codes (STBC), i.e., their need for symbol synchronization and signalling overhead for cooperation setup. Furthermore, the presented cooperation scheme is designed with the aim of improving the overall network performance, while most of the proposals in the literature focus on single link performance. SM is integrated with decision- feedback multiuser receivers for both the non-cooperative and the cooperative phases in order to maximize the use of radio resources. The cooperation efficiency is further enhanced by using a hybrid automatic repeat request (ARQ) mechanism for error control, implemented with linear erasure packet codes. Also in this case, the packet-based coding allows to have no signalling overhead for cooperation. Extensive results are provided, obtained by simulation of the complete PHY and MAC layers for a realistic network scenario with several nodes.
Monoclonal antibody reactive with both p28 and p19 of adult T-cell leukemia virus-specific polypeptides. (1983)

Mouse monoclonal antibodies, GIN-2, -7 and -14, against adult T-cell leukemia virus (ATLV) were prepared by a hybridoma procedure. These antibodies belonged to different subclasses of IgG, but they reacted similarly with both ATLV-specific polypeptides p19 and p28. In the reaction with monoclonal antibodies and various ATLV-producer cell lines, it was found that MT-2 and MT-2-related T-cell lines produced both p19 and p28, whereas MT-2-unrelated cell lines produced p19, but not p28.
Chromosome Lesions Produced with an Argon Laser Microbeam without Dye Sensitization (1971)

Improvements in the argon laser microbeam have made it possible to cause damage to chromosomes of tissue culture cells without prior treatment of the cells with a photosensitizing agent. These results have been confirmed independently in two laboratories.