gebhart/patrepeval huggingface dataset:
Controlled drug delivery from biomaterials used for cardiac repair (2012)

The continued risk of death due to heart failure has spurred the advancement of biomaterials-based treatments for cardiac repair, two of which are the application of a cardiac patch or intramyocardial material injection. The inclusion of signaling molecules in these materials can improve the treatment results; however, appropriate molecule delivery is not trivial. This research presents the broad application of therapeutics from both a patch and injectable system to demonstrate how system properties influence drug delivery and how these systems may be engineered to provide added benefit in the desired application. We demonstrated the ability to release a gene-inducing molecule, Rheoswitch ligand 1 (RSL1), from a biodegradable elastomer that has been used as a cardiac patch. Not only was bioactive RSL1 released over an extended period, the ability to differentially load scaffolds with RSL1 allowed for spatial patterning of gene expression in cells cultured on the scaffold surface, which has implications for creating complex 3D tissues in vitro. This same elastomeric material was able to release bioactive insulin-like growth factor 1 (IGF1) and hepatocyte growth factor (HGF) in vitro. The complex release behavior of IGF1 into saline was replaced by a much simpler release profile during simulated in vivo degradation, demonstrating that the implant environment must be considered when studying drug delivery behavior. A strong, thermoresponsive and degradable hydrogel was developed for intramyocardial injection. We showed the release rates of a model protein from this gel, or from protein-loaded microparticles inside the gel, could be controlled by changing the material composition. The combination of hydrogel with microparticles delivered two proteins in a sequential manner. We further used this system to release bioactive basic fibroblast growth factor (bFGF) followed by IGF1 in vitro. Injection of the unloaded polymer into infarcted rat hearts was able to improve the remodeling process for at least 16 weeks. While increased tissue bFGF and IGF1 were demonstrated following injection of growth factor-loaded gels, there were no clear benefits seen from protein inclusion. This points to the primary ability of the hydrogel alone to benefit cardiac function and cellular environment and warrants further investigation.
The effect of physiological concentrations of bile acids on in vitro growth of Mycobacterium tuberculosis (2012)

Certain bile acids alone and in combination, at physiological concentrations, inhibit the growth of MTB in vitro. This might explain why intestinal TB occurs in the ileocaecum in the majority of cases and why gallbladder TB is very rare.
Knowledge guided data mining (1995)

Intelligent Applications Ltd. have recently completed the final phase of the development of a software model for a client. The client has a very large number of customers made up from members of the general public. The model predicts which customers of the client have an increased likelihood of being lost to a competitor. The model was developed by performing data mining on a representative set of data from the client, using knowledge-guided induction. One of the main benefits to the client is the provision of intelligence, resulting from the data mining, to help them target their mailshot campaigns and other marketing exercises in the most effective way. The model has undergone extensive tests and validation routines to measure its accuracy based on customer data taken from a 3-year time window. The model has consistently yielded extremely high accuracies for most customer types, and more than 90% for certain customer types in particular. (3 pages)
Analysis of a common-antigen lipopolysaccharide from Pseudomonas aeruginosa (1989)

Lipopolysaccharide isolated from Pseudomonas aeruginosa PAO1 (O5 serotype) was separated into two antigenically distinct fractions. A minor fraction, containing shorter polysaccharide chains, reacted with a monoclonal antibody to a P. aeruginosa common antigen but did not react with antibodies specific to O5-serotype lipopolysaccharide. In contrast, fractions containing long polysaccharide chains reacted only with the O5-specific monoclonal antibodies. The shorter, common-antigen fraction lacked phosphate and contained stoichiometric amounts of sulfate, and the fatty acid composition of this fraction was similar to that of the O-antigen-specific fraction. The lipid A derived from the serotype-specific lipopolysaccharide cross-reacted with monoclonal antibodies against lipid A from Escherichia coli, while the lipid A derived from the common antigen did not react. We propose that many serotypes of P. aeruginosa produce two chemically and antigenically distinct lipopolysaccharide molecules, one of which is a common antigen with a short polysaccharide and a unique core-lipid A structure.
Distributed Air Quality Monitoring Based on Bluetooth Sensing Nodes and Virtual TEDS (2007)

A smart sensor network implemented for air quality monitoring that includes a set of multivariable sensing nodes designed and using appropriate solid state sensors and low power consumption multi-input acquisition devices is presented. The communication between the nodes and a host personal computer (PC) that is used for advanced data processing and data logging is performed through a sensor channel acquisition interface characterized by class1 Bluetooth and serial port profile in order to emulate serial cable connections using RFCOMM between two peer devices. The non-linear characteristics of the air quality sensors requires the implementation of inverse modeling processing blocks at the PC level, which are materialized using IEEE 1451 standard elements such as virtual transducer electronic data sheet (Virtual - TEDS). A proposed neural network TEDS solution is also referred in the paper.
Characterization of CdZnTe Crystals Grown Using a Seeded Modified Vertical Bridgman Method (2009)

In this paper, several 60 mm diameter CdZnTe crystal ingots, containing large-size single crystals, were grown using (111) or (211) orientation seeds by the modified vertical Bridgman method. The Zn concentration distribution along the axial direction of the ingots was measured by near-infrared transmission spectroscopy at room temperature. The partition coefficient of Zn during the growth was calculated to be about 1.2. Zinc distribution uniformity measurements were carried out using photoluminescence mapping measurement at 80 K, which showed that the band gap variation in the CdZnTe wafers is less than 0.004 eV. IR microscopy showed that the diameters of the Te inclusions present in the material are in the range 6-9 mum, and the density of the inclusions is 1~3times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . IR transmission measurements in the wave number region from 500 to 4000 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> demonstrate that the IR transmittance of CdZnTe wafers is higher than 60%. Current-voltage measurements were performed on test structures fabricated using thermally evaporated Au contacts deposited on as-grown crystals, which revealed bulk resistivity values of 2~5times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> Omegamiddotcm. Typical leakage currents for the planar devices were <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">~</i> 4 nA at a field strength of 1500 Vcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . The electron and hole mobility-lifetime products were evaluated using alpha particle irradiation. The obtained typical (mutau) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</sub> and (mutau) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">h</sub> values for the as-grown CdZnTe were 2.3times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> and 1.5times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , respectively.
Albumin inhibits adipogenesis and stimulates cytokine release from human adipocytes (2006)

Bovine serum albumin (BSA) is commonly used in adipocyte experiments as a binding protein for fat-soluble substances. Therefore, it is of interest to investigate whether BSA per se is influencing the functioning of human adipocytes in vitro. In the present study, we investigated the potential of BSA to affect the proliferation and differentiation capacity of human preadipocytes. BSA was found to inhibit adipose differentiation in a dose-dependent manner (being significant at concentrations of 2.5 microM), whereas proliferation was not affected. We further investigated the effect of BSA on the secretory function of adipocytes focusing on the release of selected cytokines. Preadipocytes and freshly isolated adipocytes incubated with BSA secreted significantly higher amounts of IL-6, -8, and -10, and TNF-alpha compared with cells incubated without BSA. The effects on cytokine secretion seemed to reside at the level of gene expression because BSA increased TNF-alpha and IL-6 mRNA in a dose-dependent manner. The results of the present study indicate that the presence of BSA in the culture medium has considerable effects on adipocyte function in vitro. These effects should be carefully considered for in vitro studies of adipose tissue.
Full-CMOS 2-GHz WCDMA direct conversion transmitter and receiver (2003)

This paper presents a full-CMOS transmitter and receiver for 2.0-GHz wide-band code division multiple access with direct conversion mixers and a DC-offset cancellation scheme. The direct conversion scheme combined with a multiphase sampling fractional-N prescaler alleviates the problems of the direct conversion transmitter and receiver. Digital gain control is merged into the baseband filters and variable-gain amplifiers to optimize the linearity of the system, reduce the noise, and improve the sensitivity. Variable-gain amplifiers with DC-offset cancellation loop eliminate the DC-offset in each stage. The chip implemented in 0.35-μm CMOS technology shows the experimental results of 6 dBm maximum output power with 38-dB adjacent channel power rejection ratio at 1.92 MHz, 50-dB dynamic range, and 363-mW power consumption in the transmitter. The receiver shows -115.4 dBm sensitivity, a 4.0-dB noise figure, and a dynamic range of 80-dB with 396-mW power consumption.
Respiratory syncytial virus and other respiratory viruses in the setting of bone marrow transplantation (2009)

Respiratory viral infections occur frequently after hematopoietic stem cell transplant. Newer agents may prove useful in the prevention and treatment of respiratory viral infections in this population.
Prototypes and production rules: a knowledge representation for computer consultations (1980)

This thesis presents a system called CENTAUR, which demonstrates the effectiveness of representing prototypical knowledge in a combination of frames and production rules for performing computer consultations. Key knowledge representation and control structure problems in production rule systems similar to MYCIN are identified, and a set of important characteristics of the structures used for representing problem-solving knowledge is given. CENTAUR's frames, or prototypes, complement the production rules to satisfy these characteristics and represent expected patterns of data that permit a more focused, hypothesis-directed approach to problem solving. Among the characteristics identified as desirable in the representation structures are the ability to explicitly represent (a) prototypical cases, (b) the context in which knowledge is applied, and (c) the strategies for applying that knowledge. CENTAUR's prototypes consist of patterns of knowledge in the domain which serve as broad contexts, guiding the more detailed processing of the production rules. Strategies for the consultation, or control knowledge, are represented in the prototypes separately from other kinds of domain knowledge. This allows the domain expert to specify control knowledge that is specific to each prototype. Examples are presented which demonstrate how this explicit representation facilitates explanations of the system's reasoning. Further, the organization of knowledge in CENTAUR provides a useful framework for acquiring new knowledge.
Changes in the Reproduction of Heterodera glycines on Different Lines of Glycine max. (1984)

Selection for ability of soybean cyst nematode (SCN), Heterodera glycines, to reproduce on soybeans with different sources of resistance divides some SCN race 4 field populations into two distinct subpopulations. These subpopulations reproduce well on 'Bedford' and plant introduction (PI) 88788 or PI 89772 and PI 90763 but not on both pairs of soybean lines. The ability of these subpopulations to reproduce on the four soybean lines was reversed by changing the soybean line used as a host during a second cycle of selection. When SCN populations previously selected for reproduction on Bedford and PI 88788 were selected for their ability to reproduce on D72-8927 and J74-88, the ability of these populations to reproduce on Bedford and PI 88788 decreased significantly and their ability to reproduce on PI 89772 and PI 90763 increased significantly. Conversely, when SCN populations, previously selected for reproduction on P189772 and P190763, were selected for their ability to reproduce on Bedford, the reproduction of these populations on Bedford increased significantly and reproduction on PI 89772 and PI 90763 decreased significantly. Selection for ability of a SCN race 4 field population to reproduce on soybean lines derived from SCN race 4 resistant PIs resulted in the same division of the field population into two distinct subpopulations. These data substantiate earlier proposals to rotate cultivars with different genes for SCN resistance as a means of managing SCN populations.
Teaching of occupational medicine to undergraduates in UK schools of medicine (2003)

Despite the prominence given to issues related to occupational health in recent UK government policy, this study suggests a declining commitment to occupational medicine on the part of UK medical schools. Urgent action needs to be taken to address the lack of training in occupational medicine in UK medical schools.
Die Anreicherung des leichten Uranisotops nach dem Diffusions‐Verfahren (1957)

Abstract Die Grundlagen des Diffusionsverfahrens zur Anreicherung von 235 U und die Methoden zur Ermittlung der günstigsten Betriebsbedingungen werden in Anlehnung an die von Cohen, Benedict, Dirac u. a. entwickelte Optimaltheorie des Trennprozesses dargestellt. Es wird gezeigt, wie sich die offiziell nicht bekannte Produktionsleistung der amerikanischen Trennanlagen aus ihrem Stromverbrauch abschätzen läßt. Bei einer angenommenen Verarmung des Abfallmaterials auf 1/5 der Normalkonzentration ergibt sich eine Produktionsleistung von ca. 25 d̊ 235 U/Jahr als 20proz. Material und ein Verbrauch an natürlichem Uran von ca. 4400 d̊/Jahr. Die Wirtschaftlichkeit des Trennprozesses wird charakterisiert durch einen „spezifischen elektrischen Aufwand”︁ ς = 9000 kWh/kg U und eine „spezifische Investierung”︁ ζ = 560 $/kg U im Jahr. Der offizielle amerikanische 235 U‐Preis entspricht im wesentlichen der Summe aus den Strom‐ und Materialkosten.
A Security Language for BPMN Process Models (2011)

Security mechanisms are essential for business processes. Currently, business-process-management systems (BPMSs) provide relatively little security support, and programmers must be familiar with interfaces of security mechanisms that are not part of BPMSs. Enforcing security constraints for a business process leads to high implementation and maintenance costs. Our approach in turn is a wholistic one, providing security support from the modelling to the runtime phase of a businessprocess lifecycle. As current security-modelling approaches lack features important for business processes, we propose a sophisticated language to formulate respective constraints. In addition, we considerably ease the specification of how users can control their security preferences at runtime. Our security language is embedded in BPMN. We have extended an open-source BPMS on the modelling, configuration and execution layer. The BPMS extensions transform BPMN schemas with security constraints into executable secure processes in a versatile manner. Our language is sufficiently broad, because we have systematically realized all requirements identified in a complex, real-world scenario.
Cancer incidence in hypertensives (1987)

Cancer incidence was measured over a 5-year period (1978 to 1982) in 4067 hypertensive patients, and 10,366 normotensive patients from general practices in southwestern Ontario. For cancer of all sites an elevated incidence was found among hypertensive patients. The elevation was most pronounced among newly diagnosed hypertensive patients, with hypertension of moderate or greater severity, and for sites that have been described in clinical reports as being capable of producing a rise in blood pressure. It is tentatively concluded that the causal direction is from cancer to hypertension, rather than the reverse. If this conclusion is correct, the associations that have been reported between cancer mortality and hypertension may be due to an effect of blood pressure upon survival from cancer.
Electroluminescent II–VI Heterojunctions (1971)

D‐C electroluminescence in II–VI films is still in its infancy and could become of great technical importance if the problem of efficient hole injection in the absence of p‐n homojunctions can be solved, which is possible through systematic efforts. A survey is given of the existing methods of hole injection and of the available materials combinations. Their advantages and short‐comings are listed, and as a conclusion a new method is proposed.
Real-Time Operating Systems for Small Microcontrollers (2009)

Real-time operating systems have gained popularity in microcontroller- and processor-based embedded system design. This article discusses differences between RTOSs and generic operating systems, the advantages and disadvantages of using RTOSs for small microcontroller system development, and the benchmarking methods used for RTOSs. Benchmarking results for four RTOSs show no clear winner, with each RTOS performing better on some criteria than others.
Stereoselective Synthesis of C<sub>60</sub>-Based Cyclopropane Amino Acids (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTStereoselective Synthesis of C60-Based Cyclopropane Amino AcidsBeatriz Illescas, Joan Rifé, Rosa M. Ortuño, and Nazario MartínView Author Information Departamento de Química Orgánica, Facultad de Química, Universidad Complutense, E−28040 Madrid, Spain, and Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain [email protected]Cite this: J. Org. Chem. 2000, 65, 19, 6246–6248Publication Date (Web):August 24, 2000Publication History Received17 March 2000Published online24 August 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/jo0003955https://doi.org/10.1021/jo0003955brief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views351Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon,Hydrocarbons,Molecules,Monomers,Peptides and proteins Get e-Alerts
Cell death, cavitation and spontaneous multi‐differentiation of dental pulp stem cells‐derived spheroids <i>in vitro</i>: A journey to survival and organogenesis (2014)

DPSC-derived spheroids can mimic the developmental process of cell survival, cavitation and spontaneous multi-differentiation on matrigel under certain conditions. This work allows for functional studies to investigate organ regeneration with human DPSCs in vitro.
On real-time delay monitoring in software-defined networks (2014)

The paper introduces a new loop-based method to measure end-to-end packet delay in software-defined network infrastructures. Although the method generates auxiliary service packets, it does not require any complementary support from the switching hardware. The prototype implementation shows the method is able to provide one-way delay values with microsecond precision on a steady load. Direct application of the method to each data flow in the network is straightforward, but can cause excessive hardware utilization. Thus, the paper proposes an algorithm to improve it by decomposing global end-to-end estimations into the set local ones whereas removing their redundancy. The algorithm makes it practically possible to monitor delay of each data flow in real-time.
The Pharmacological Treatment of Cachexia (2004)

Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities such as glucose intolerance, fat depletion, and muscle protein catabolism among others. The aim of the present article is to review the different therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure.
A wide-bandwidth low-voltage PLL for PowerPC microprocessors (1995)

A 3.3 V Phase-Locked-Loop (PLL) clock synthesizer implemented in 0.5 /spl mu/m CMOS technology is described. The PLL supports internal to external clock frequency ratios of 1, 1.5, 2, 3, and 4 as well as numerous static power down modes for PowerPC microprocessors. The CPU clock lock range spans from 6 to 175 MHz. Lock times below 15 /spl mu/s, PLL power dissipation below 10 mW as well as phase error and jitter below /spl plusmn/100 ps have been measured. The total area of the PLL is 0.52 mm/sup 2/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pseudocholinesterasen Pharmakgenetik; Biochemie; Klinik (1967)

Book Revtewsirritating not to find 'thalassemia' or 'hemoglobino- pathy', though 'globinopathies' appears.The defects are relatively minor and the book as a whole succeeds admirably in its object.There can be
Synthetic analgesics (1948)

F. Bergel and A. L. Morrison, Q. Rev. Chem. Soc., 1948, 2, 349 DOI: 10.1039/QR9480200349