gebhart/patrepeval huggingface dataset:
FACTORS AFFECTING THE THYROID GLAND UPTAKE OF I<sup>131</sup>OF THE<i>RANA CATESBEIANA</i>TADPOLE<sup>1</sup> (1959)

Various factors affecting thyroid gland uptakes of I131 of the tadpole have been studied. The species of Rana catesbeiana was used since they were widely available the year around in the larval form. All observations, except for one study, were made on non-metamorphosing tadpoles fasted 7 to 14 days. Temperature had a marked effect on the uptake and must be critically controlled to compare responses of these poi kilo thermic animals. The responses varied during the months of the year being greatest in April and least in October, November and December. When single injections of TSH and I131 were given the greatest difference in the mean uptake between the stimulated and unstimulated tadpoles was observed when TSH was given 68 hoursand I131 24 hours before sacrifice. Twentyfive /xg. triiodothjTonine placed in the tadpole water bathof approximately 1200 ml. suppressed the 24 hour uptake by 50%. This effect occurred within 24 hours and lasted at least 96 hours. The response to TSH was not decreased by the tri...
The Effect of Coadministration of Duloxetine on Steady-State Serum Concentration of Risperidone and Aripiprazole: A Study Based on Therapeutic Drug Monitoring Data (2010)

Previous studies have categorized duloxetine as a moderate inhibitor of CYP2D6. The aim of the present study was to investigate the potential interactions between duloxetine and the two CYP2D6 substrates risperidone and aripiprazole in psychiatric patients. Serum concentration data from patients treated with risperidone (n = 8) or aripiprazole (n = 7) in combination with duloxetine were retrieved from therapeutic drug monitoring files at the Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway. The degree of interaction was assessed by comparing the data with a control group of CYP2D6-genotyped patients (homozygous "extensive metabolizers") using oral risperidone or aripiprazole without duloxetine. Coadministration of duloxetine did not significantly increase the concentration of the parent drug or the parent drug/metabolite ratio of either risperidone or aripiprazole. The present study therefore indicates that duloxetine may safely be used concomitantly with risperidone or aripiprazole.
London Approximation with the Finite Core Size for the Mixed State of Type II Superconductor (1998)

The mixed state of type II superconductor was studied by means of the Wigner-Seitz approximation at κ ≫ 1 for the entire range of magnetic fields between Hc1 < H0 < Hc2. The vortex structure was described in the framework of the improved London model with finite core radius by the introduction of the order parameter in form of a constant function at ρ > ρm and a variational function at ρ < ρm, where ρm is the core radius. The dependencies of magnetic induction, core radius, vortex amplitude upon the external magnetic field at Hc1 < H < Hc2 were derived, the values of the first and the second critical fields as well as the critical vortex radius were calculated. The obtained results are in a good agreement with the results received by Abrikosov and Brandt. Der gemischte Zustand von Supraleitern II. Art wird im Grenzfall κ ≫ 1 und für das ganze Intervall des Magnetfelds zwischen Hc1 < H0 < Hc2 mit Hilfe der Wigner-Seitz-Näherung behandelt. Die Struktur der Flußlinie wird beschrieben im Rahmen des verbesserten Modells von London mit endlichem Vortex-Kern bei Einführung des Ordnungsparameters in Form einer konstanten Funktion für ρ > ρm und einem Variationsansatz für ρ < ρm, wobei ρm der Radius des Kerns ist. Abhängigkeiten der magnetischen Induktion, des Kernradius und der Amplitude der Flusslinie vom äußeren Magnetfeld bei Hc1 < H < Hc2 wurden erhalten. Die Werte des ersten und zweiten kritischen Magnetfelds und des kritischen Radius der Flusslinie wurden berechnet. Die erhaltenen Resultate stimmen gut mit den Resultaten von Abrikosov und von Brandt überein.
AUDITORY SENSITIVITY OF THE GOLDFISH WITHIN THE NEAR ACOUSTIC FIELD (1969)

Abstract : Four experiments were conducted on auditory sensitivity and discrimination of goldfish within the acoustic near field. Experiment I studies the effects of the near field on sound pressure thresholds. The sensitivity of goldfish in terms of sound pressure appeared to vary with distance from the sound source. Experiment II studied stimulus generalization and frequency discrimination within the near field. A generalization gradient was observed which indicated that goldfish can discriminate a frequency change as small as 12.5% without explicit differential training. Experiment III studied the effects of far field noise on near field thresholds. A masking effect was observed which appeared to be a negatively accelerated function of masker spectrum level. Experiment IV tested the ability of goldfish to localize a sound source within the near field. It was shown that goldfish could discriminate between right 45 degrees and left 45 degrees stimulus directions. Implications of the results of the four experiments are discussed.
α-(2,3,5,6-Tetrachlorophenyl)-α-(3-thienyl)acetonitrile and α-(3-Methoxyphenyl)-α-(2,3,4,5,6-pentachlorophenyl)acetonitrile (1995)

The C-Cl distances of the tetrachlorophenyl moiety in α-(2,3,5,6-tetrachlorophenyl)-α-(3-thienyl)acetonitrile, (1), C 12 H 5 Cl 4 NS, are in the range 1.713(3)-1.720(3) A, and those of the pentachlorophenyl moiety in α-(3-methoxyphenyl)-α-(2,3,4,5,6-pentachloro-phenyl)acetonitrile, (2), C 15 H 8 Cl 5 NO, are in the range 1.695 (9)-1.734 (8) A. The thienyl ring of compound (1) is almost planar and the dihedral angle between the phenyl and thienyl rings is 78.8 (1)°, while that between the two phenyl planes of compound (2) is 88.6 (3)°.
Low afterpulsing and narrow timing response InGaAs/InP Single-Photon Avalanche Diode (2013)

We designed, fabricated and tested a new planar InGaAs/InP Single-Photon Avalanche Diode (SPAD). By optimizing design and fabrication processes, we obtained low afterpulsing and very good timing jitter, with very fast tail. The detector has a separate absorption, charge and multiplication structure, with double p-type Zn diffusion into n-type InP for defining the p-n high-field avalanching junction. The SPAD can be operated at temperatures achievable with thermoelectric coolers mounted in compact packages (like TO-8). When operated in gated mode with 5 V excess bias, the 25 μm active area diameter InGaAs/InP SPAD reaches good performance at 225 K: i) photon detection efficiency of 40% at 1 μm and 25% at 1.55 μm; ii) dark count rate below 100 kcps (counts per second); iii) low afterpulsing allowing to set a hold-off time as short as 1 μs, corresponding to 1 Mcps; iv) timing jitter less than 90 ps (full width at half maximum) and time constant of decaying tail of just 30 ps. Overall this new planar InGaAs/InP SPAD can be exploited in many near-infrared (up to 1.7 μm) applications where low light, wide dynamic range waveforms have to be acquired, e.g. in Time-Correlated Single-Photon Counting (TCSPC) measurements or Time-of-Flight LIDAR applications for eye-safe 3D ranging.
Recent Advancements in Functional Movement Analysis (1995)

The purpose of this paper is to describe the concept of Functional Movement Analysis (FMA) and review the recent advancements pertaining to the clinical application of FMA. After a brief introduction to the concept of FMA, the role computers have played in FMA development is presented. A generalized movement measurement technique is introduced along with the resulting benefits associated with the implementation of body segment based coordinate systems. Finally, the role of mechanical power estimates and movement synthesis techniques in the future maturation of FMA is considered.
Growth Hormone Secretagogue (GHS) Analogue, Hexarelin Stimulates GH From Peripheral Lymphocytes (2002)

The role of growth hormone releasing hormone (GHRH) and growth hormone releasing peptide-6 (GHRP-6) analogue hexarelin was investigated in the regulation of GH production from lymphocytes. Porcine and bovine blood mononuclear cells were separated using density gradient centrifugation method by layering the whole blood or buffy coat cells on lymphodex. Cells were incubated for 3 or 5 days with or without phytohemagglutinin (PHA-M), GHRH, GHRP-6 analogue hexarelin, somatostatin or GHRH + hexarelin. Growth hormone was fractionated from supernatants by gel chromatography and further concentrated by lyophilization at - 20 degrees C. A nearly two fold increase in basal secretion of GH (porcine: 3.5 +/- 0.1 ng/ml, bovine: 3.2 +/- 0.2 ng/ml) was achieved by GHRH and hexarelin at concentrations of 0.1, 1.0, 10 and 100 nM in both porcine and bovine cells. Lymphocytic GH release was also stimulated in response to PHA-M (10 micro g/well). Neither a dose dependent nor a synergistic nor an additive effect was apparent on GH secretion from lymphocytes. GHRH stimulated lymphocytic GH secretion, whereas, somatostatin had no effect. This study reports for the first time that hexarelin stimulates the secretion of GH from peripheral lymphocytes.
Achieving Conventional Mixture Performance in High Reclaimed Asphalt Pavement Mixtures Using Rejuvenators and Polymer-Modified Asphalt (2015)

Softer binders have been used to compensate for the stiffness of reclaimed asphalt pavement (RAP) binders in mixtures; however, several studies have shown that asphalt rejuvenators can allow more RAP to be incorporated in mixtures than softer binders alone. Nevertheless, rejuvenators are not encouraged by some state agencies because of potential rutting-related concerns. The effect of five asphalt rejuvenators on the performance of a 50% RAP surface layer mixture was evaluated in terms of rutting and cracking. Furthermore, the use of Polymer Modified Asphalt (PMA) was evaluated to ascertain if it can remedy any rutting performance degradation while maintaining or improving the cracking characteristics of the mixtures. The objective was to produce mixtures with high RAP content that perform similar to or better than the all-virgin material control mixture. The results illustrated that the rejuvenators used in this study degraded the rutting resistance of the 50% RAP mixtures, but the use of the PMA binders remedied these performance degradations. The rejuvenators improved the fatigue cracking resistance of the 50% RAP mixture to a level higher than the all-virgin materials control mixture and the 50% RAP mixture with the softer binder alone. Overall, the data indicated that a combination of asphalt rejuvenators and PMA is required to yield a high RAP mixture with similar or better performance than a similar conventional mixture.
Novel Fluorescent Aluminum Complexes Based on <i>N</i>-Hydroxy-3,6-diaryl-4-phenyl-2-pyridone Ligands (2008)

Abstract Novel fluorescent aluminium complexes of N-hydroxy-3,6-diaryl-4-phenyl-2-pyridone derivatives were synthesized and their fluorescent properties were investigated. The complexes having a trifluoromethyl group and a methoxy group at the para-position on the 3- and 6-phenyl groups exhibit purple fluorescence in the solid state.
Effect of Temperature on Electrical and Thermal Properties on Carbon Soot Filled Polyester Graded Composites (2014)

This article reports the development, DC conductivity behavior of carbon soot filled polyester graded composites. Carbon soot filled polyester composites having 3 wt% of carbon soot powder and polyester resin were prepared. DC conductivity measurements were conducted on the graded composites by using an electrometer in the temperature range of 28°C to 150°C. DC conductivity increased with increase in carbon soot concentration in the composites; DC conductivity increased with the increase in temperature. Activation energy was calculated by using Arrhenius equation for graded samples exhibited electronic conduction. Linear dependence of pre-exponential factors on activation energy for carbon soot filled polyester graded composites reveals semi-conducting behavior of the composites.
Well Completion Optimization in a North Dakota Bakken Oilfield (2010)

Abstract First discovered in 1951, development of the Bakken formation in the Williston Basin has been problematic and inconsistent. However, technological advancements in horizontal drilling and completions in the past decade have steadily improved production results and consistency on a well by well basis. So much so, that the United States Geologic Survey (USGS) reported in 2008 that the undiscovered, technically recoverable oil in the Bakken was between 3 to 4.3 billion barrels. How many fracture stages to run and how far apart to space stages in horizontal wells are prevalent questions asked by the oil and gas industry. This study provides insight into the advantages of various stage numbers and optimum stage spacing by analyzing up to 15 months of production results from horizontal wells targeting the Bakken in the Stanley Field, North Dakota. These wells were completed with open hole, multi-stage fracturing systems (OHMS) and production is compared to offset wells and field averages. Advancements in OHMS completion and fracturing technology have enabled maximized production from this asset. The lessons learned and methodology can be utilized for other unconventional oil and gas plays around the world.
The effect of clutter on the automatic target classification accuracy in FSR (2010)

The clutter influence on the automatic target classification (ATC) accuracy in forward scattering radar (FSR) is presented. To study the ATC at various signal-to-clutter ratios (SCR), a simulated vegetation clutter is artificially added to the real clutter-free targets recorded signals. It is shown that using conventional clutter-uncompensated ATC system can achieve high target classification accuracy at high SCR only, but the accuracy drops significantly with SCR decreasing. The employment of clutter-compensated ATC system is shown to improve significantly the classification accuracy at low SCR.
Naked Viruses That Aren't Always Naked: Quasi-Enveloped Agents of Acute Hepatitis (2014)

Historically, viruses were considered to be either enveloped or nonenveloped. However, recent work on hepatitis A virus and hepatitis E virus challenges this long-held tenet. Whereas these human pathogens are shed in feces as naked nonenveloped virions, recent studies indicate that both circulate in the blood completely masked in membranes during acute infection. These membrane-wrapped virions are as infectious as their naked counterparts, although they do not express a virally encoded protein on their surface, thus distinguishing them from conventional enveloped viruses. The absence of a viral fusion protein implies that these quasi-enveloped virions have unique mechanisms for entry into cells. Like true enveloped viruses, however, these phylogenetically distinct viruses usurp components of the host ESCRT system to hijack host cell membranes and noncytolytically exit infected cells. The membrane protects these viruses from neutralizing antibodies, facilitating dissemination within the host, whereas nonenveloped virions shed in feces are stable in the environment, allowing for epidemic transmission.
Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine (2012)

Abstract Objectives Previous studies have developed calcium phosphate and fluoride releasing composites. Other studies have incorporated chlorhexidine (CHX) particles into dental composites. However, CHX has not been incorporated in calcium phosphate and fluoride composites. The objectives of this study were to develop nanocomposites containing amorphous calcium phosphate (ACP) or calcium fluoride (CaF 2 ) nanoparticles and CHX particles, and investigate Streptococcus mutans biofilm formation and lactic acid production for the first time. Methods Chlorhexidine was frozen via liquid nitrogen and ground to obtain a particle size of 0.62 μm. Four nanocomposites were fabricated with fillers of: nano ACP; nano ACP + 10% CHX; nano CaF 2 ; nano CaF 2  + 10% CHX. Three commercial materials were tested as controls: a resin-modified glass ionomer, and two composites. S. mutans live/dead assay, colony-forming unit (CFU) counts, biofilm metabolic activity, and lactic acid were measured. Results Adding CHX fillers to ACP and CaF 2 nanocomposites greatly increased their antimicrobial capability. ACP and CaF 2 nanocomposites with CHX that were inoculated with S. mutans had a growth medium pH > 6.5 after 3 d, while the control commercial composites had a cariogenic pH of 4.2. Nanocomposites with CHX reduced the biofilm metabolic activity by 10–20 folds and reduced the acid production, compared to the controls. CFU on nanocomposites with CHX were three orders of magnitude less than that on commercial composite. Mechanical properties of nanocomposites with CHX matched a commercial composite without fluoride. Significance The novel calcium phosphate and fluoride nanocomposites could be rendered antibacterial with CHX to greatly reduce biofilm formation, acid production, CFU and metabolic activity. The antimicrobial and remineralizing nanocomposites with good mechanical properties may be promising for a wide range of tooth restorations with anti-caries capabilities.
Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility (2018)

Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to degradation of cardiomyocyte sarcomeric components by intracellular matrix metalloproteinase-2 (MMP-2). We recently reported that MMP-2 levels were increased in the border zone after a MI and that treatment with doxycycline for two weeks after MI was associated with normalization of MMP-2 levels and improvement in ex-vivo contractile protein developed force in the myocardial border zone. The purpose of the current study was to determine if there is a sustained effect of short term treatment with doxycycline (Dox) on border zone function in a large animal model of antero-apical myocardial infarction (MI). Antero-apical MI was created in 14 sheep. Seven sheep received doxycycline 0.8 mg/kg/hr IV for two weeks. Cardiac MRI was performed two weeks before, and then two and six weeks after MI. Two sheep died prior to MRI at six weeks from surgical/anesthesia-related causes. The remaining 12 sheep completed the protocol. Doxycycline induced a sustained reduction in intracellular MMP-2 by Western blot (3649±643 MI+Dox vs 9236±114 MI relative intensity; p = 0.0009), an improvement in ex-vivo contractility (65.3±2.0 MI+Dox vs 39.7±0.8 MI mN/mm2; p<0.0001) and an increase in ventricular wall thickness at end-systole 1.0 cm from the infarct edge (12.4±0.6 MI+Dox vs 10.0±0.5 MI mm; p = 0.0095). Administration of doxycycline for a limited two week period is associated with a sustained improvement in ex-vivo contractility and an increase in wall thickness at end-systole in the border zone six weeks after MI. These findings were associated with a reduction in intracellular MMP-2 activity.
Advanced control system design for high speed ultra accurate manufacturing systems (1997)

In this paper we describe the application of a robust adaptive control design to an ultra accurate (sub-micron) linear and planar step motor known as the Sawyer motor (1969). Simulation results presented show promising improvement in performance with the advocated controller.
Positron emission tomography imaging of colorectal cancer. (1999)

Continued improvements in the diagnosis and treatment of colorectal cancer are based on a clearer understanding of the pathophysiological processes underlying the disease and how it affects the patient. The addition of information derived from fluorine-18-labeled deoxyglucose (FDG) positron emission tomography (PET) scans to the cross-sectional imaging data enables a clearer understanding of the pathophysiology of the disease process. In particular, FDG PET scans are capable of demonstrating disease that mimics normal structures on conventional imaging, as well as finding disease in otherwise normal-sized lymph nodes. Abnormal areas of FDG uptake in the setting of known colorectal cancer are almost always due to recurrent disease. In addition, FDG PET offers great promise in the evaluation of treatment response, particularly as more targeted therapies become available. This report covers the basic principles underlying PET imaging, including the biochemistry of FDG and methods of PET analysis. We then, review the clinical indications for FDG PET scanning in colorectal cancer.
The Thermal Effect in the Elongation and Relaxation of Rubber (1955)

Abstract Samples of natural rubber and synthetic rubber were stretched, and the temperature rises were followed by a thermocouple. The heat evolution was found to correspond to an adiabatic process. The study of the dependence of the heat effect (the Gough-Joule effect) on time shows that, while stretched, rubber crystallizes slowly and the phenomenon can be followed experimentally for several hours. The final stage of crystallization is probably a first-order reaction, the velocity constant of which is nearly independent of the percentage elongation and which has a small temperature coefficient. On the contrary, fusion following release of the applied stress is relatively rapid.
Robust Control Approaches For A Two-link FlexibleManipulator (1970)

Control approaches for a two-link flexible manipulator are studied in the context of robust synthesis for Linear Parameter-Varying systems. Different treatments of the inertia matrix variations in the manipulator system are examined in three control law design formulations. The first two designs are based upon scaled H^ or structured singular value synthesis. The third design makes use of a new approach for robust gain-scheduled synthesis. Results show that this gain-scheduling technique maximizes both performance and robustness over the entire range of manipulator configurations.
Guest Editors' Introduction: Speeding Up Analog Integration and Test for Mixed-Signal SoCs (2015)

The seven articles in this special section initiatives to standardize methods, measurements, and tools that support mixed-signal design. The papers are organized along the lines of the overall design-to-test flow, covering verification, selection of test content, defect level estimation, silicon validation, and data-driven test optimization and yield recovery. Presents examples on how to perform comprehensive verification, how to measure and ensure adequate analog test coverage, and how to create and track a specification compliance matrix across the entire design-to-manufacturing flow.
Alteration of lymphocyte function in nzb/nzw mice (1979)

Abstract NZB/NZW F 1 female mice received levamisole in an attempt to increase suppressor T cell function. Responses varied with dosage of drug and age of mice. When treatment with 25 μg/gm doses (intermittent or daily) was begun at 12 weeks of age, nephritis was accelerated in spite of transient reduction of anti‐DNA antibodies. When treatment was begun at 4 weeks, or when doses of 250 μg/gm were given, no clinical effects were observed. In the mice with accelerated disease, delayed hypersensitivity and antibody responses to sheep erythrocytes increased; antibody responses to pneumococcal poiysaccharide were unaffected. It is possible that some increased immune responses associated with levamisole are undesirable in murine lupus.