gebhart/patrepeval huggingface dataset:
CLINICAL STUDY: Subjective responses and cardiovascular effects of self‐administered cocaine in cocaine‐abusing men and women (2008)

This study aimed to examine sex differences in cocaine self-administration and cocaine-induced subjective and cardiovascular measures. The research was based on secondary analysis of data collected in our human laboratory in which subjects self-administered cocaine infusions (8, 16 and 32 mg/70 kg) over a 2-hour period under a fixed ratio 1, 5 minute time out schedule in three test sessions. Subjects were 10 women and 21 men with a history of either cocaine abuse or dependence who were not currently seeking treatment. Women and men self-administered similar amounts of cocaine. None of the subjective effects measures showed a significant main effect of sex during the cocaine self-administration session. Significant interactions were observed for subjective ratings of 'high' (sex x time) and 'stimulated' (sex x time x dose), with women reporting lower ratings over time/doses than men. Relative to men, cocaine produced dose- and time-dependent increases in feelings of hunger (i.e., reduced appetite suppression) in women. Systolic and diastolic blood pressures showed different patterns of change in men and women, with women showing less robust cocaine-induced increases than men. Taken together, these findings suggest that women and men may differ in their subjective and cardiovascular responses to self-administered cocaine. Further research that prospectively controls for hormonal influences upon these measures is needed.
Structure-Mutagenicity and Structure-Cytotoxicity Studies on Bromine-Containing Cysteine S-Conjugates and Related Compounds (1994)

Glutathione and cysteine S-conjugates of several haloalkenes are nephrotoxic and cytotoxic. Chloroalkene-derived S-(1-chloroalkenyl)-L-cysteine conjugates, but not fluoroalkene-derived S-(2,2-dihalo-1,1-difluorethyl)-L-cysteine conjugates, are mutagenic in the Ames test, although both types of S-conjugates are cytotoxic and nephrotoxic. Recent studies showed that bromine-containing S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteine conjugates are mutagenic in the Ames test, thus challenging the generalization that S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteine conjugates are not mutagenic. Hence a series of bromine-containing and bromine-lacking S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteine conjugates was prepared, and their mutagenicity was assessed in the Ames test with Salmonella typhimurium TA2638 as the test strain. In addition, several indices of cytotoxicity, including cytotoxicity in LLC-PK1 cells, induction of Ca2+ release from pig kidney mitochondria, and DNA double-strand breaks in LLC-PK1 cells, were measured. The bromine-containing S-conjugates S-(2-bromo-2-chloro-1,1-difluoroethyl)-L- cysteine (BCD-FC), S-(2-bromo-1,1,2-trifluoroethyl)-L-cysteine (BTFC), and S-(2,2-dibromo-1,1-difluoroethyl)-L-cysteine (DBDFC) were mutagenic in the Ames test, whereas S-(2-chloro-1,1,2-trifluorethyl)-L-cysteine (CTFC), S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine (DCDFC), and S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFC), which lack bromine, were not. BCDFC, BTFC, CTFC, DBDFC, and TFC were cytotoxic in LLC-PK1 cells, and their cytotoxicity was blocked by the cysteine conjugate beta-lyase inhibitor (aminooxy)acetic acid.(ABSTRACT TRUNCATED AT 250 WORDS)
Mössbauer Studies of Spin Flop in Antiferromagnetic Hematite (1965)

The antiferromagnetic sublattice magnetizations below the Morin transition temperature TM≈260°K, are parallel and antiparallel to the trigonal axis of rhombohedral α-Fe2O3. Experiments at 80°K, using the Mössbauer technique together with high external magnetic fields on both polycrystalline and single-crystal samples, show that the directions of the sublattice magnetizations flop from along the trigonal axis for the applied field H0&lt;Hc to perpendicular to the trigonal axis for H0&gt;Hc; Hc is found to be 67.5±3 kOe. In the polycrystalline sample this behavior is exhibited through the occurrence of a maximum in the width of the outer lines of the Mössbauer spectrum plotted as a function of H0. In the single crystal, which is oriented so that the gamma rays propagate along the [111] direction, the magnetic transition is clearly observed as a sudden qualitative as well as quantitative change in the appearance of the Mössbauer hyperfine spectrum; below the critical field the Δm=0 lines are the strongest components of the six-line spectrum.
Passively mode-locked thin disk lasers reach 10 microjoules pulse energy at megahertz repetition rate and drive high field physics experiments (2007)

The direct generation of high energy pulses with a diode-pumped solid-state laser oscillator is a promising approach to enable the multi-megahertz operation of numerous applications in science and industry. Thin disk lasers enable the required average power with excellent beam quality, such that passive mode locking with a semiconductor saturable absorber mirror (SESAM) can be achieved. Using this concept, the authors have recently been able to reach a pulse energy as high as 5.1 muJ at 12 MHz repetition rate from an Yb:YAG thin disk oscillator. This significant increase over previous results was made possible by realizing the importance of the nonlinearity of air inside a thin disk laser cavity. To eliminate the air's contribution to the nonlinearity, the laser was covered with a box which then was flooded with helium. Here a further increase in pulse energy to 11 muJ is presented. The existing 40.7 MHz laser cavity presented was extended to a total of 37 m, by inserting a 23.4 m long multiple-pass cavity (MPC) and a simple 4f extension using curved mirrors with 5000 mm radius of curvature. This resulted in a repetition rate of 4 MHz, at which we achieved an average power of 45 W when operated in the box flooded with helium. The sech <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -shaped pulses had a FWHM-duration of 791 fs and a spectral bandwidth of 1.56 nm, resulting in a time-bandwidth product of 0.35 (Fourier-limit: 0.315). The beam quality was nearly diffraction-limited with an M <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -value of 1.1 (measured at 9.4 muJ).
Synthesis and complexing properties of calix dendrimers (2006)

The present paper is a timely review of a work developed in the laboratory and dealing with the chemistry of dendrimers. The main originality of these dendrimers is that they contain only calix[4]arene units by taking advantage of their 1,3-selective dialkylation. The linking of the calixarenes is made by amidation reaction with tri primary amines serving as branches.
Advances in PNNL’s Vanadium Redox Flow Battery Stack (2013)

Abstract not Available.
A compact fast-neutron producing target for high resolution cross section measurements (2006)

A proper knowledge of neutron cross sections is very important for the operation safety of various nuclear facilities. Reducing uncertainties in the neutron cross sections can lead to an enhanced safety of present and future nuclear power systems. Accurate neutron cross sections also play a relevant role in many other disciplines such as astrophysics, medicine, and security. Therefore it is essential to have at disposal tools to measure the neutron cross sections at required resolution. The measurement accuracy required to extract properly resonance parameters of the cross sections can only be obtained at time-of-flight facilities specially designed to have a high resolution in energy. Among the other neutron TOF facilities available in the world, the bremsstrahlung-based Geel Electron LINear Accelerator (GELINA) facility of the Joint Research Centre of the European Commission in Belgium is the one with the best energy resolution. The main goal of this thesis was to investigate the possibilities to improve even further the capabilities of this neutron data measurement facility. The thesis describes a design study with the purpose to further enhance the quality of the GELINA facility by proposing a new neutron producing target. It is demonstrated that there is a potential for an improved target to allow GELINA users to measure neutron cross sections with even higher accuracy. Therefore an effort was made to optimize the size, shape, and material composition of such a target design in view of the optimal neutron source characteristics, while providing an adequate solution for target cooling. The final design consists of seven 3 x 3 cm2 U-Mo plates with well-defined thicknesses in the direction of the beam. A plate-by-plate optimization has been carried out in order to maximize the neutronics properties of the target, while keeping the maximum plate temperatures reasonably low. A tantalum cladding coats each U-Mo plate to provide the required containment of radioactive material, and to avoid the direct contact of the U-Mo alloy with the Hg coolant. Seven Hg channels located in between the plates cool the target.
Combined dose‐ratio analysis of cholecystokinin receptor antagonists, devazepide, lorglumide and loxiglumide in the guinea‐pig gall bladder (1992)

1. Interactions between cholecystokinin octapeptide (CCK-8) and CCKA-receptor antagonists derived from benzodiazepines (devazepide) and glutamic acid (lorglumide and loxiglumide) have been examined in an improved bioassay using the guinea-pig, isolated, gall bladder preparation. 2. The presence of CCKB-receptors in the assay was provisionally-ruled out on the basis of the low potency of pentagastrin in the assay. By applying analyses of both agonism and antagonism, pentagastrin was shown to behave as a partial agonist at the CCKA-receptor. 3. Devazepide, lorglumide and loxiglumide behaved as simple competitive antagonists of CCKA-receptors and pKB values of 9.98, 7.59 and 7.07 were estimated, respectively. 4. Application of a combined dose-ratio analysis to the interactions between CCK-8 and combinations of devazepide/lorglumide and devazepide/loxiglumide indicated that these molecules behave as syntopic, competitive, antagonists at the CCKA-receptor. 5. We conclude that the guinea-pig gall bladder assay contains a homogeneous population of CCKA-receptors and offer an explanation for the differences between our results and those obtained recently by Maubach et al. (1991) which were taken as preliminary evidence for CCKA-receptor heterogeneity.
βII-Tubulin and βIII-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells (2011)

Abstract Increased abundance of βII- and βIII-tubulin isotypes in cancer cells confers resistance to vinca and taxoid site drugs; however, the role of these isotypes in the acquired resistance of cancer cells to non-vinca or non-taxoid site binding agents has not been described. Peloruside A (PLA) and laulimalide are the only known non-taxoid site microtubule-stabilizing agents. A human ovarian cancer cell line, 1A9-L4 (L4), previously selected in high concentrations of laulimalide, has both a single point mutation in βI-tubulin and overexpression of βII- and βIII-tubulin. The cells are highly resistant to PLA as well as laulimalide but show no cross-resistance to taxoid site drugs or drugs that bind to the vinca site on β-tubulin. To understand the functional significance of the βII- and βIII-tubulin changes in this resistant cell line, isotype-specific short interfering RNA was used to knock down the expression of the βII and βIII isotypes, and the cellular effects of PLA and laulimalide were examined before and after silencing. It was found that inhibition of βII- and βIII-tubulin partially sensitized L4 cells to PLA and laulimalide, as seen by increased potency of PLA and laulimalide for inducing growth inhibition, cellular tubulin polymerization, microtubule aberrations, and G2-M arrest in the resistant cells. The sensitivity to paclitaxel, vinblastine, ixabepilone, and cisplatin was unaffected by the inhibition of isotype expression. It was concluded that the increased βII- and βIII-tubulin contributed significantly to the resistance phenotype, along with the tubulin structural mutation, and that the altered isotype effect was binding site specific. Mol Cancer Ther; 11(2); 393–404. ©2011 AACR.
Amphiphilic Block Copolymers by Sequential Living Cationic Polymerization:  Synthesis and Characterization of Poly(isobutylene-<i>b</i>-methyl vinyl ether) (1996)

The living polymerization of methyl vinyl ether (MeVE) was achieved using initiators obtained by capping 2,4,4-trimethyl-2-chloropentane (TMPCl) with 1,1-diphenylethylene (DPE), or 1,1-ditolylethylene (DTE) in conjunction with TiCln(OEt)4-n (n = 2−2.4) coinitiator in CH2Cl2/hexanes (60/40 v/v) solvent mixture at 0 °C. Sequential block copolymerization of isobutylene (IB) with MeVE has also been accomplished. Well-defined living poly(isobutylene) (PIB) was first prepared at −80 °C in the presence of TiCl4, followed by capping with DPE or DTE. Then, Ti(OEt)4 was added to reduce the Lewis acidity followed by the addition of MeVE, and the temperature was raised to 0 °C. Well-defined PIB-PMeVE diblock copolymers with controlled molecular weight and narrow molecular weight distribution (Mw/Mn < 1.1) have been obtained, with the virtual absence of homopolymer contaminants. According to differential scanning calorimetry, the diblock copolymers exhibit two Tgs, suggesting microphase separation. PIB-PMeVE diblock copolymers with ∼50/50 w/w composition were insoluble in water but soluble in methanol. The diblock copolymer with 80 wt % PMeVE content was soluble in water, exhibited excellent surfactant properties (critical micelle concentration = 2.3 × 10-5 M), and produced stable emulsions of oil in water (average particle size ∼200 nm).
MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer (2010)

miRNAs are small-noncoding RNA molecules that regulate gene expression on a posttranscriptional level. A number of oncogenes and tumor suppressors were found to be targets of miRNAs and global miRNA expression signatures were able to distinguish between cancerous and non-cancerous tissues. Therefore it was not surprising that some miRNAs could be linked to the pathogenesis of cancer. In this review we provide an overview of the use of microRNAs as diagnostic and prognostic tools in cancer and focus on the use of miRNA expression as biomarker for disease activity.
Subscribing to datastore push updates (2014)

This document defines a subscription and push mechanism for
datastores. This mechanism allows client applications to request
updates from a datastore, which are then pushed by the server to the
client per a subscription policy, without requiring additional client
requests.
Dose Calculations from Source Models and Gamma-Ray Spectra (2020)

Gamma-ray dose rates computed by two radiation source model-based methods and five measured spectrum-based methods are compared. With the exception of a Detective DX-100, which reported dose rates that are about 25% less than the mean, dose rates are generally within 10% of mean values. Methods for computation of dose rates employed by the Gamma Detector Response and Analysis Software (GADRAS) are described and critically evaluated. Results are presented for a feasibility evaluation that seeks to use spectra recorded inside vehicles to estimate the minimum dose outside the vehicles.
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF‐kB activation (2003)

Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria.
CitySpectrum (2014)

People flow at a citywide level is in a mixed state with several basic patterns (e.g. commuting, working, commercial), and it is therefore difficult to extract useful information from such a mixture of patterns directly. In this paper, we proposed a novel tensor factorization approach to modeling city dynamics in a basic life pattern space (CitySpectral Space). To obtain the CitySpectrum, we utilized Non-negative Tensor Factorization (NTF) to decompose a people flow tensor into basic life pattern tensors, described by three bases i.e. the intensity variation among different regions, the time-of-day and the sample days. We apply our approach to a big mobile phone GPS log dataset (containing 1.6 million users) to model the fluctuation in people flow before and after the Great East Japan Earthquake from a CitySpectral perspective. In addition, our framework is extensible to a variety of auxiliary spatial-temporal data. We parametrize a people flow with a spatial distribution of the Points of Interest (POIs) to quantitatively analyze the relationship between human mobility and POI distribution. Based on the parametric people flow, we propose a spectral approach for a site-selection recommendation and people flow simulation in another similar area using POI distribution.
Myocardial Ischemia due to Obstruction of an Aortocoronary Bypass Graft by Intraoperative Positioning (1985)

Departments of Anesthesiology and Cardiothoracic Surgery, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire. Address correpondence to Dr. Weinlander, Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Hanover, NH 03756. The authors thank Kristin Lanphear for manuscript preparation and Drs. Quentin J. Durward and Bruce D. Hettleman, of the Sections of Neurosurgery and Cardiology, respectively, for their involvement in this case. Accepted for publication April 29, 1985.
Periodontal Tissue Bioengineering: Is the Future Now? (2018)

Periodontitis affects nearly half of the adult population in the United States and leads to periodontium destruction, tooth loss, and tooth mobility. Novel bioengineering has become an area of interest in dentistry, as various approaches aim to regenerate attachment apparatus around diseased teeth with the use of barriers, scaffolds, bone grafts, or biologics. This article emphasizes recent findings in the fields of stem cell/gene therapy, 3-dimensional printing, and innovative scaffold designs for future applications in clinical care.
Incidence of irregular astigmatism eligible for contact lens fitting after Descemet membrane endothelial keratoplasty (2013)

Dr. Melles is a consultant to DORC International BV/Dutch Ophthalmic USA. No author has a financial or proprietary interest in any material or method mentioned.
A Constant-Temperature-Operation Hot-Wire Anemometer (1959)

The behavior of a hot-wire anemometer is analyzed using signal flow diagrams, especially for the case of a constant-temperature-operation anemometer, comprising a dc bridge and a dc differential amplifier. The influence of static bridge unbalance and of the amplifier's gain for in-phase input signals on the over-all dynamic characteristics is analyzed, and requirements for the amplifier are derived. A chopper-stabilized amplifier is employed, which automatically maintains static bridge balance under all operating conditions. The signal-to-noise ratio for comparable instruments having constant-current operation and constant-temperature operation is shown to be equal. Results of measurements are reported; they are in fair agreement with the developed theory. A nonlinear circuit is described, which delivers a voltage directly proportional to the instantaneous air velocity.
The Nellix device: review of indications and outcome (2017)

Despite improvements in endograft design, operator skills, and patient selection, late endovascular abdominal aortic aneurysm repair (EVAR) associated complications and need for reinterventions remains the Achilles heel. These complications erode the early benefit over open aneurysm repair during long-term follow-up. The recently introduced endovascular aneurysm sealing (EVAS) is an innovative technology with the intention to lower these EVAR related complications. Areas covered: In this review the EVAS technique, indications, and possible applications, will be discussed, as well as a critical appraisal of clinical outcomes. Expertcommentary: EVAS is a promising technique for treating abdominal aortic aneurysms, and early efficacy data are encouraging in very suitable straight forward anatomy. The Nellix device is still in development. Longterm results are awaited.
ChemInform Abstract: Experimental and Theoretical Study on the Structure of Nitramide H<sub>2</sub>NNO<sub>2</sub>. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ala analogues of the cyclolinopeptide A (1989)

Analogues of cyclolinopeptide A, due to the replacement of each amino acid in the Pro1-Pro2-Phe3-Phe4 sequences with an L-Ala residue, were synthesized by classical method in solution. Mixed anhydride and N,N'-dicyclohexylcarbodiimide coupling methods have been used for the synthesis of both linear and cyclic peptides. The products were characterized by Rf values and uv spectra, as well as by fast atom bombardment spectroscopy. 1H-nmr studies on [Ala2] analogues are also reported. Preliminary data in CDCl3 solution, at low temperature, seems more promising.
ADMINISTRATION OF REPEATED DOSES OF ANTI-CD40L AND DONOR BONE MARROW LEADS TO HEMATOPOIETIC CHIMERISM AND DONOR SPECIFIC TOLERANCE WITHOUT CYTOREDUCTIVE CONDITIONING. (2000)

Durham, Megan M.1; Bingaman, Adam W.1; Adams, Andrew B.1; Ha, Jongwon1; Waitze, Seung-Yeun1; Pearson, Thomas C.1; Larsen, Christian P.1 Author Information
On the normal acceleration sensitivity of contoured quartz resonators stiffened by quartz cover plates supported by clips (1992)

Recent work has shown that both the normal and resultant in-plane acceleration sensitivities of contoured quartz resonators vanish for a perfectly symmetric resonator and support system. It has also been shown that any loss of symmetry in the combined resonator plus support configuration results in a significant degradation in the acceleration sensitivity. Since it is essentially impossible to construct a perfectly symmetric resonator plus support configuration in practice, a stiffened structure is considered. The structure consists of the active biconvex quartz resonator attached to identical top and bottom quartz cover plates by means of small sidewalls around the periphery. The mounting clips are attached to the top and bottom cover plates without touching the active plate. An analysis of the normal acceleration sensitivity of this configuration is performed. Results are presented for a mispositioning of either a clip or the mode shape for a range of thickness of cover plates relative to the active plate.
A Journey from Quetta to Meshed via the Nushkisistan Trade-Route: Discussion (1902)

sand desert, in which I was caught in a sand-storm. The desert extends for about 30 miles, and is reputed to be infested by robbers, but nobody tried to attack me, though Mr. Foley, who followed me some weeks later, was, I believe, hindered.