gebhart/patrepeval huggingface dataset:
Preparation of polyamides derived from 1,6‐diamantane dicarboxylic chloride by solution polycondensation and interfacial polycondensation (1995)

Abstract 1,6‐Diamantane dicarboxvlic acyl chloride ( I ) was used as a monomer with various aromatic diamines to synthesize polyamides by interfacial polycondensation and solution polycon‐densation. The polyamides prepared by interfacial polycondensation had inherent viscosities between 0.38 and 0.15 dL/g. The polyamides prepared by solution polycondensation had inherent viscosities between 0.62 and 0.25 dL/g. The polyamides IIIa prepared by solution polycondensation showed the main melting transition at 380°C by dynamic mechanical analysis. In addition, it was quite temperature‐stable and maintained good mechanical properties (G′⋐10 8 Pa) up to high temperatures close to the main transition well above 350°C. The polyamide IIIA had a tensile strength of 35 MPa, elongations to break of 10%, and initial modulus of 0.8 GPa. Some of the polyamides were soluble in NMP, DMAc, and DMSO, depending on soft segment moiety of diamine ( II ). The polyamides prepared by interfacial polycondensation have a greater tendency to form crystal than those prepared by solution polycondensation, as evidenced by x‐ray diffraction studies. These polyamides had glass transition temperatures in the 270–300°C range, and 5% weight loss temperatures up to 435°C in nitrogen. © 1995 John Wiley & Sons, Inc.
Genomic Replikin Counts of Infectious Salmon Anemia Virus (ISAV) in Canada Exceed the Counts in Lethal Outbreaks in Norway, Chile, and Scotland. Real-Time Tracking of the Evolution of the ISAV Genome and the Resultant Replikins Solid Phase ISAV Vaccine Make ISAV Pandemic Prevention Possible. (2012)

Genomic Replikin CountsTM of Infectious Salmon Anemia Virus (ISAV) in Canada Exceed the Counts in Lethal Outbreaks in Norway, Chile, and Scotland. Real-Time Tracking of the Evolution of the ISAV Genome and the Resultant Replikins Solid Phase ISAV Vaccine Make ISAV Pandemic Prevention Possible.
ChemInform Abstract: Nucleophilic Substitution Reactions of 4‐Aryl‐5‐carbomethoxy‐6‐methyl‐ 2‐chloro‐3‐cyanopyridines. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Control of Antigenic Variation in African Trypanosomas (1993)

Trypanosomes are unicellular organisms belonging to the Kinetoplastida, a group of protozoa that diverged early from the eukaryotic lineage (Sogin et al. 1989). The African trypanosomes, such as Trypanosoma brucei (Fig. 1), are parasites of mammals that cause a low-grade innocuous chronic infection of wild life in central Africa. T. brucei is transmitted between mammals by the tsetse fly. Most African trypanosome species, including T. brucei brucei, cannot infect primates. However, host-range mutants of T. brucei, called T. brucei gambiense and T. brucei rhodesiense, have adapted to humans and cause sleeping sickness.
Antigen-specific t lymphocyte clones. II. Purifcation and biological characterization of an antigen-specific suppressive protein synthesized by cloned T cells (1981)

We have generated an antigen-specific T suppressor clone that synthesizes 70,000-mol wt peptides that have antigen-specific-binding activity. Although these data also indicated that antigen-binding peptides completely inhibited the in vitro primary response to a complex antigen, suppression might reflect the combined biologic activities of many different 70-mol wt polypeptides or polypeptides associated with the 70,000-mol wt material by noncovalent interactions. The protein responsible for antigen-specific suppression was therefore purified to virtual homogeneity after sequential separation of internally labeled supernate peptides on Sephacryl S-200 and DEAE-cellulose columns followed by isoeleetrofocusing. The resulting protein is greater than 95 percent homogeneous according to sodium dodeeyl sulfate-polyacrylamide electrophoresis and represents two peptides having two very close but distinguishable isoelectric point values of approximately 5.0. The purified molecules are retained by columns coated with lentil lectin or antigen but not by columns coated with antisera specific for immunoglobulins, the I region of the major histocompatibility complex or Ly-1 or Ly-2 antigens. Less than 50 pg of the purified glycoprotein specifically and completely suppresses production of anti-sheep erythrocyte plaque-forming cell by mixtures of 10(6) Ly-1 cells and B cells and this is a result of inactivation of Ly-l-mediated helper function. Specific inactivation of T (Th) cells by the 70,000-mol wt molecule is rapid, specific, and requires the presence of antigen. The mechanism of specific suppression of Th function may depend upon two functionally distinct regions of the 70,000-mol wt molecule: one that binds antigen and a second that mediates suppression.
LAAS Sigma-Mean Monitor Analysis and Failure-Test Verification (2001)

The Local Area Augmentation System (LAAS) is a ground-based differential GPS system being developed to support aircraft precision approach and landing navigation with guaranteed integrity. Stanford University has designed, implemented and tested a LAAS ground Facility (LGF) prototype, known as the Integrity Monitor Testbed (IMT), which is used to insure that the LGF meets its requirements for navigation integrity. One significant integrity risk is that the mean of the pseudorange correction error distribution becomes nonzero or that its standard deviation (sigma) grows to exceed the broadcast correction error sigma (σpr_gnd) during LAAS operation. Real-time mean and sigma monitoring is necessary to help insure that the true error
The Base Substitution Fidelity of DNA Polymerase β-dependent Single Nucleotide Base Excision Repair (2003)

Damaged DNA bases are removed from mammalian genomes by base excision repair (BER). Single nucleotide BER requires several enzymatic activities, including DNA polymerase and 5',2'-deoxyribose-5-phosphate lyase. Both activities are intrinsic to four human DNA polymerases whose base substitution error rate during gap-filling DNA synthesis varies by more than 10,000-fold. This suggests that BER fidelity could vary over a wide range in an enzyme dependent manner. To investigate this possibility, here we describe an assay to measure the fidelity of BER reactions reconstituted with purified enzymes. When human uracil DNA glycosylase, AP endonuclease, DNA polymerase beta, and DNA ligase 1 replace uracil opposite template A or G, base substitution error rates are <or=0.3 to <or=2.8 x 10-4. BER error rates are higher when excess incorrect dNTPs are included in the reaction or when wild type DNA polymerase beta is replaced by DNA polymerase beta variants that fill single nucleotide gaps with lower fidelity. Under these conditions, the base substitution fidelity of polymerase beta-dependent BER is 3-8-fold higher than is single nucleotide gap filling by polymerase beta alone. Thus other proteins in the BER reaction may enhance the base substitution fidelity of DNA polymerase beta during single nucleotide BER.
Session details: MedGEC'15 Workshop (2015)

Welcome to MedGEC 2015
Raman microprobe analysis on gaseous inclusions from the diagenetically altered Terres Noires (S-E, France) (1988)

Raman microprobe determinations have been made on primary gaseous inclusions in quartz crystals found in concretions from diagenetically altered Jurassic sediments from S-E France. The gas compositions vary as a general function of the diagenetic grade of the enclosing sediments. Two major types of gas inclusions were found, a wet gas in the western part of the basin and a dry gas in the eastern part. The proportions of CH4, C2H6, C3H8, CO2, H2S and N2 were determined to within one percent of the amount present. The gas mixtures and fluid phase assemblages indicate that these materials were entrapped during the evolution of the organic and mineral rock assemblages induced by increases of temperature and pressure. There is no evidence for change of the organic material posterior to its entrapment as a fluid inclusion. UV fluorescence optical observations indicate that organic liquids are present in the primary inclusions and also in secondary inclusions situated in healed cracks. These secondary inclusions are found in the whole area. UV fluorescence measurements indicate that this trapped material could be an extract from a more evolved organic material than that found in primary inclusions. These secondary inclusions could have been formed during tectonic event of the Alpine orogenies.
Lab 4: the Atwood machine (2015)

This book provides 13 labs spanning the common topics in the first semester of university-level physics. Each lab is designed to use only the student's smartphone, laptop and items easily found in big-box stores or a hobby shop. Each lab contains theory, set-up instructions and basic analysis techniques. All of these labs can be performed outside of the traditional university lab setting and initial costs averaging less than $8 per student, per lab.
Porcine tissue plasminogen activator (1986)

Tissue plasminogen activator was purified in high yield from pig heart by immunoaffinity chromatography and characterized by analysis of the glycosylation pattern and the N-terminal amino acid sequence. Comparisons with the human enzyme reveals residue exchanges in the A-chain at positions 3 (porcine Arg/human Gln) and 5 (Thr/Ile), and in the B-chain at positions 6 (Tyr/Phe), 10 (Thr/Ala) and 20 (Val/Ala). The glycosylation pattern for the porcine activator was determined by endoglycosidase treatment followed by gel electrophoresis. The A-chain contains a single high-mannose type of N-linked glycan structure and the B-chain contains a complex type of oligosaccharide. A similar but not identical pattern has been observed for the human activator, purified from melanoma cells.
Partial TMR in FPGAs Using Approximate Logic Circuits (2016)

TMR is a very effective technique to mitigate SEU effects in FPGAs, but it is often expensive in terms of FPGA resource utilization and power consumption. For certain applications, Partial TMR can be used to trade off the reliability with the cost of mitigation. In this work we propose a new approach to build Partial TMR circuits for FPGAs using approximate logic circuits. This approach is scalable, with a fine granularity, and can provide a flexible balance between reliability and overheads. The proposed approach has been validated by the results of fault injection experiments and proton irradiation campaigns.
Standardization of CSP Performance Model Projection: Latest Results From the guiSmo Project (2011)

Electricity yield projection is one of the essential tasks related to concentrating solar thermal power plants. Currently, the project engineers and other stakeholders cannot refer to standardized methods for calculation of the annual electricity outcome of such plants. In autumn 2010, the first steps were taken to initiate an international project within SolarPACES Task I that targets the development of reliable methodologies for yield projection [1, 2]. More than 80 international participants from academia, industry, and finance agreed to work together within the guiSmo project (Guidelines for CSP performance modelling). Intended as an open project with publicly available results, CSP stakeholders are invited to join the team. Since initiation of the project, a coordination team and supervisory board have been founded. The challenging task is subdivided into ten “work packages” that cover all aspects of CSP project analysis — from elementary plant models to transient effects and financial evaluation approaches. This paper provides an overview of recent achievements and upcoming activities in the guiSmo project. The focus is on the definition of three quality levels for yield projection as they will be required during the various project development phases.
Multifunctional Hydrophobin: Toward Functional Coatings for Drug Nanoparticles (2010)

Efficient delivery of nanosized drug formulations to the desired body sites is not always reached despite the rapid development of pharmaceutical nanotechnologies. In spite of the undoubted effect of the size for increased bioavailability and controlled drug delivery, submicrometer formulations also require a deeper level of design. The surface properties of the particles determine the stability of the particles, interactions with the body, and targeting potentials of drugs. Thus, the efficacy of the drug can be increased utilizing the surface layer of the nanoparticles. Influencing the surface characters of the drug is the main focus of the present work, which introduces a method for preparing nanoparticles with functional sites from low-solubility drugs using hydrophobin (HFB) proteins. Particles were prepared by precipitating a lipophilic drug (beclomethasone dipropionate) in water in the presence of the HFB proteins. Particle size below 200 nm could easily be reached with increasing HFB concentration. The particles were shown to be stable for at least 5 h in suspension, and they could be stored for longer periods of time after freeze-drying. Labeling studies using green fluorescent protein (GFP) genetically fused to a HFB clearly demonstrated that the surface of the nanoparticles was covered with the hydrophobins and that the surface could be further modified by utilizing fusion proteins. This provides a template for a variety of different functional surface-bound groups that could be tailored by modifying the hydrophilic side of the HFB via protein bioengineering. In this study, the combination of proteins and traditional pharmaceutical technology was used to synthesize functionalized protein-coated nanoparticles for drug delivery purposes.
Effects of 2 Years' Treatment of Osteoporosis with 1 a-Hydroxy Vitamin D3 on Bone Mineral Density and Incidence of Fracture: A Placebo-Controlled, Double-Blind Prospective Study. (1996)

A two-year double-blind study monitored and evaluated the effects of 1 alpha-hydroxy vitamin D3 (1 alpha(OH)D3) on the lumbar (L2-4BMD) and total body bone mineral densities (TBBMD) and occurrence of fracture in 113 female osteoporotic patients receiving 0.75 micrograms/day of 1 alpha(OH)D3 (n = 57) or a placebo (n = 56) with calcium supplementation in both groups. L2-4BMD increased 1.81.% and 2.32% after one and 2 years in the 1 alpha (OH)D3 group, but decreased 1.89% (P < 0.05) and 0.28% in the placebo group. A significant difference (P < 0.01) existed between the two groups after one year. TBBMD decreased significantly in the placebo group by 3.34% (P < 0.01) and 3.52% after one and 2 years. Six new fractures occurred in the control group, but only two in the 1 alpha(OH)D3 group (Odd's ratio = 0.343, 95% confidence range; 0.0648-1.815). There were no serious adverse effects of the 1 alpha(OH)D3 treatment. It was concluded that two-year treatment with 1 alpha(OH)D3 increased the lumbar BMD and inhibited the decrease in TBBMD. Although it was not significant, new fracture occurrence in the 1 alpha(OH)D3 group was around 1/3 of that in the control group.
Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney. (1985)

Clearance experiments were carried out in pair-fed rats to examine the long-term effects of adrenalectomy and selective adrenal corticosteroid replacement in physiological amounts on renal potassium transport. To this end, clearance studies were conducted in rats that were sham operated, or adrenalectomized (ADX). ADX animals were given either vehicle, aldosterone (0.5 microgram/100 g body wt per day), dexamethasone (1.2 micrograms/100 g body wt per day), or aldosterone and dexamethasone, by osmotic minipump for 7-9 d whereupon clearance experiments were conducted. After chronic hormone treatment, during basal conditions when only Ringers solution was infused, all groups excreted similar amounts of potassium. However, in all ADX animals without mineralocorticoid replacement, the maintenance of urinary potassium excretion at control levels was associated with hyperkalemia, increased urine flow, and natriuresis; all are factors known to stimulate urinary potassium excretion. During acute potassium infusion, the increase in urinary potassium excretion was less in ADX rats than in controls. This functional deficiency in potassium excretion was partially corrected by dexamethasone and was uniformly associated with a significant increase in urine flow. Aldosterone replacement or aldosterone and dexamethasone given together chronically, sharply increased potassium excretion but did not restore excretion to control levels. Only acute aldosterone infusion (0.2 microgram/100 g body wt bolus plus 0.2 microgram/100 g body wt per hour), superimposed upon chronic aldosterone and dexamethasone treatment, fully restored potassium excretion to control levels. This aldosterone induced enhancement of potassium excretion, both chronic and acute, was not associated with hyperkalemia, and increased urine flow or natriuresis. Thus, physiological levels of both classes of adrenal corticosteroids stimulate renal potassium excretion albeit by different mechanisms. Mineralocorticoids stimulate tubular potassium excretion directly, whereas glucocorticoids augment excretion indirectly by increasing fluid and sodium delivery along the distal nephron.
Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction (2000)

When the heart fails, there is often a constellation of biochemical alterations of the beta-adrenergic receptor (betaAR) signaling system, leading to the loss of cardiac inotropic reserve. betaAR down-regulation and functional uncoupling are mediated through enhanced activity of the betaAR kinase (betaARK1), the expression of which is increased in ischemic and failing myocardium. These changes are widely viewed as representing an adaptive mechanism, which protects the heart against chronic activation. In this study, we demonstrate, using in vivo intracoronary adenoviral-mediated gene delivery of a peptide inhibitor of betaARK1 (betaARKct), that the desensitization and down-regulation of betaARs seen in the failing heart may actually be maladaptive. In a rabbit model of heart failure induced by myocardial infarction, which recapitulates the biochemical betaAR abnormalities seen in human heart failure, delivery of the betaARKct transgene at the time of myocardial infarction prevents the rise in betaARK1 activity and expression and thereby maintains betaAR density and signaling at normal levels. Rather than leading to deleterious effects, cardiac function is improved, and the development of heart failure is delayed. These results appear to challenge the notion that dampening of betaAR signaling in the failing heart is protective, and they may lead to novel therapeutic strategies to treat heart disease via inhibition of betaARK1 and preservation of myocardial betaAR function.
Epidermal Growth Factor Increases Insulin Secretion through Phospholipase D2 activation (2006)

Epithermal growth factor (EGF) regulates pancreatic β‐cell survival, proliferation, and differentiation. EGF is synthesized in the pancreas and found in pancreatic juice, and diabetic animals have low levels of EGF. However, the role of EGF in regulating insulin secretion, the major function of pancreatic β‐cells, has not been studied. Here we show that EGF rapidly and specifically stimulates insulin secretion in mouse pancreatic islets, as well as in a pancreatic β‐cell line (MIN6 cells). These events were dependent on Ca 2+ influx and phospholipase D (PLD) activity, particularly PLD2. In addition, EGF also increased plasma insulin levels and mediated glucose lowering in mice in vivo. Here, for the first time, we provide evidences that EGF as a novel secretagogue regulating plasma glucose levels and find the mechanism of EGF‐induced insulin secretion.
Wide-Screen Television (1957)

A television system known as “Scanoscope” has been developed in which the aspect ratio has been changed from the conventional 4 × 3 format into an 8 × 3 presentation. Advantages are analogous to those in wide-screen motion pictures. The process is based on the Scanoscope lens described in the succeeding paper in this Journal. This lens squeezes the image on the camera focal plane, from which it is transmitted with the required megacycle bandwidth. The image is unsqueezed electronically in the monitor. The optical and electronic features are described.
Interferometric Observations of V1663 Aquilae (Nova Aql 2005) (2007)

We have resolved the classical nova V1663 Aql using long-baseline near-IR interferometry covering the period from 5--18 days after peak brightness. We directly measure the shape and size of the fireball, which we find to be asymmetric. In addition we measure an apparent expansion rate of 0.21 +/- 0.03 mas/day. Assuming a linear expansion model we infer a time of initial outburst approximately 4 days prior to peak brightness. When combined with published spectroscopic expansion velocities our angular expansion rate implies a distance of 8.9 +/- 3.6 kpc. This distance measurement is independent of, but consistent with, determinations made using widely available photometric relations for novae.
Antenna Measurements at Millimeter Wavelengths - Overview (2018)

Testing of electrically large antennas as well as that of electrically small integrated antennas at millimeter wavelengths is very challenging. In this overview we discuss the physical and technical challenges and limitations in testing of the various kinds of mm-wave antennas.
Constituents of <i>Withania Somnifera</i> Dun. Part X The Structure of Withanolide D (1968)

Abstract Withanolide D, the major component of the leaves of Withania somnifera chemotype II, is a steroidal lactone of the withanolide type, isomeric with withaferin A. It has been identified as 5, 6β‐epoxy‐4β, 20α‐dihydroxy‐1‐oxo‐(5β)witha‐2, 24‐dienolide. The structure has been elucidated by NMR measurements and by chemical degradation to 4β‐acetoxy‐5,6β‐epoxy (5β) pregnan‐1, 20‐dione.
HIV-1 TAT represses transcription of the bone morphogenic protein receptor-2 in U937 monocytic cells (2005)

The bone morphogenetic protein receptor-2 (BMPR2) is a member of the transforming growth factor-beta receptor family and is expressed on the surface of several cell types including endothelial cells and macrophages. Recently, a cause for familial primary pulmonary hypertension (FPPH) has been identified as mutations in the gene encoding BMPR2. Three forms of pulmonary hypertension (PH) exist, including PPH, FPPH, and PH secondary to other etiologies (sporadic PH) such as drug abuse and human immunodeficiency virus (HIV) infection. It is interesting that these subtypes are histologically indistinguishable. The macrophage is a key target cell for HIV-1, significantly altering macrophage cell function upon infection. HIV-1 trans-activator of transcription (Tat), an immediate-early product of the HIV-1 lifecycle, plays an important role in mediating HIV-induced modulation of host cell function. Our laboratory has previously shown that Tat represses mannose receptor transcription in macrophages. In the current study, we examined activity from the BMPR2 promoter in the macrophage cell line U937 and potential regulation by Tat. Transfection of U937 cells with BMPR2 promoter-reporter constructs revealed dose-dependent repression of BMPR2 promoter activity in the presence of Tat. Experiments using truncations of the BMPR2 promoter localized Tat-mediated repression to the first 208 bases of the promoter. Decreased BMPR2 transcription resulted in altered downstream signaling. Similar to mothers against decapentaplegics (SMAD) phosphorylation and SMAD6 expression, in response to BMP2 treatment, were down-regulated after Tat treatment. Finally, HIV-1 infection and treatment with Tat protein of the U937 human monocytic cell line resulted in a decreased, endogenous BMPR2 transcript copy number.