gebhart/patrepeval huggingface dataset:
HIV-induced immunodeficiency. Relatively preserved phytohemagglutinin as opposed to decreased pokeweed mitogen responses may be due to possibly preserved responses via CD2/phytohemagglutinin pathway. (1989)

We studied the proliferative response of PBL to the mitogens PHA and PWM and Candida albicans Ag in 301 HIV seropositive homosexual men, of whom 55 had AIDS. The responses to PHA were reduced only in the clinically ill HIV seropositive subjects. In contrast, the responses to PWM were profoundly reduced in most HIV seropositive subjects including the asymptomatic group. Further analysis of 16 HIV seropositive subjects showed that the proliferative responses were reduced in both CD4 and CD8 T cell subsets. A total of 15 HIV seropositive individuals with low responses to PWM, of whom seven had AIDS and eight controls were chosen for the following studies. Expression of T3, Ti, delta receptors, and CD2 was investigated and showed an increased percentage of CD2 receptors positive cells in HIV seropositive subjects without AIDS. The proliferative responses of PBL to stimulation with PHA, PWM, antibodies to CD3, or antibodies to CD2 were investigated and showed significant correlation in controls, whereas in contrast, only the responses to PHA and CD2ab correlated in patients with AIDS. The proliferative responses to CD2ab and CD3ab in controls were larger than the responses to both PHA and PWM. In patients, these responses were less suppressed than the responses to PWM indicating that stimulation with mitogens is more complex than a simple stimulation of Ti/T3 and CD2 receptors. Further investigations were done on resting T cells, i.e., lymphocytes depleted of macrophages and pre-activated cells. Addition of PHA to these cells resulted in preactivation with expression of IL-2R (CD25) but not in proliferation. In contrast, addition of PHA plus SRBC, which bind to the CD2 receptors caused IL-2R expression, IL-2 production, and proliferation. Addition of PWM + SRBC did not result in proliferation. A comparison of the responses to PHA + SRBC of resting T cells from 26 HIV seropositive individuals, of whom seven had AIDS and 12 seronegative controls, showed that these responses were normal or only slightly decreased in the 19 seropositive men without AIDS whereas it was decreased in AIDS patients. Nevertheless, all AIDS patients showed clear-cut responses in this assay. Thus, the discrepancy between responses to PHA and PWM may be explained by an at least partially preserved function of the PHA/CD2-dependent pathway. We suggest that the defect induced by the HIV infection primarily concerns T3/Ti-induced responses.
Evaluation of a Minimally Invasive pH Based Microvascular Ischemia Monitor (1998)

Postoperative monitoring of transplanted tissue for ischemia is imperative after plastic and reconstructive surgery. Existing instruments and techniques for ischemia monitoring/detection are limited because of accuracy, invasiveness and reliability. The objective of our research is to develop a phi-based ischemia monitoring system which possesses operational simplicity and accuracy to be used for continuous postoperative monitoring of transplanted tissue over a four-day period. An electronic, multi-channel pH measuring device, which interfaces with a laptop computer, was constructed, tested on animal models, and evaluated in the clinical environment. The system uses a special algorithm and five noninvasive phi reference electrodes to compensate for inherent pH measurement instabilities, providing tissue pH/ischemia monitoring that is sufficiently stable during the 96-hour postoperative observation period.
Tetrahymena rotunda n. sp. (Hymenostomatida: Tetrahymenidae), a Ciliate Parasite of the Hemolymph of Simulium (Diptera: Simuliidae) (1981)

Denis H. Lynn, Daniel Molloy, Roger LeBrun, Tetrahymena rotunda n. sp. (Hymenostomatida: Tetrahymenidae), a Ciliate Parasite of the Hemolymph of Simulium (Diptera: Simuliidae), Transactions of the American Microscopical Society, Vol. 100, No. 2 (Apr., 1981), pp. 134-141
Latent Space Sparse and Low-Rank Subspace Clustering (2015)

We propose three novel algorithms for simultaneous dimensionality reduction and clustering of data lying in a union of subspaces. Specifically, we describe methods that learn the projection of data and find the sparse and/or low-rank coefficients in the low-dimensional latent space. Cluster labels are then assigned by applying spectral clustering to a similarity matrix built from these representations. Efficient optimization methods are proposed and their non-linear extensions based on kernel methods are presented. Various experiments show that the proposed methods perform better than many competitive subspace clustering methods.
Distribution of Cerium Ions in Cerium‐Doped α′‐SiAlON and Its Effect on Grain Morphology (2002)

Cerium‐doped α′‐SiAlON material was prepared by spark plasma sintering at 1750°C under 30 MPa pressure for 10 min. Yttrium α′‐SiAlON seeds (1 wt%) were added to the starting powder mixture. Recent work showed that up to 45 wt% of α′‐SiAlON phases are formed in the present sintered ceramics. The material presented a microstructure, containing rodlike cerium‐doped α′‐SiAlON crystals. In this paper, transmission electron microscopy and energy dispersive spectroscopy examinations of the α′‐SiAlON grains are reported. The structural analyses revealed a high density of domain boundaries, within which larger amounts of cerium ions were segregated than in the matrix. The density of the domain boundaries was proportional to the amount of incorporated cerium ions. These structural defects eventually dominated the growth habits of the α′‐SiAlON crystals, by modifying the structure of the interstices at the boundary sites. The role of yttrium α′‐SiAlON seeds also is discussed in this paper.
New class of electrically conductive metallomacrocycles: iodine-doped dihydrodibenzo[b,i][1,4,8,11]tetra-azacyclotetradecine complexes (1980)

L. Lin, T. J. Marks, C. R. Kannewurf, J. W. Lyding, M. S. McClure, M. T. Ratajack and T. Whang, J. Chem. Soc., Chem. Commun., 1980, 954 DOI: 10.1039/C39800000954
Searching for biomarkers in a historic sample of Amyotrophic Lateral Sclerosis – The Munich Historic Brain Bank Project (2011)

Post-mortem analysis of CNS tissue was the gold-standard in the diagnosis of neurologic and psychiatric diseases in former times. This resulted in the storage of hundreds of thousands of precisely catalogued brain tissue specimens at our institute. As a first approach towards using these specimens for modern reanalysis, we identified 62 patients with clinical definite or probable Amyotrophic Lateral Sclerosis (ALS). After diagnostic verification, we successfully established modified methods for the isolation of genomic DNA from formalin-fixed, paraffin-embedded (FFPE) CNS tissue from glass object carriers. Despite the strong grade of DNA degradation and fragmentation, we were able to detect a variety of single nucleotide polymorphisms (SNP) which were shown to be significantly associated with ALS in recent genome-wide association studies (GWAS). 11 SNPs seem to show potential significant association in our patient sample compared to 123 neurologically healthy controls with 3 SNPs bearing p-values < 0.01. However, call rates differed to a considerable degree given the low quality of the preserved nucleic acids. Additionally, we work on standardized methods for the isolation and detection of small non-coding RNAs to take advantage of the easily accessable brain tissue. Our MPI-P historic brain bank offers unique opportunities not only for the verification but also for the discovery of new biomarkers in psychiatric or neurologic diseases.
A preliminary study of relative permeability in geothermal rocks (1995)

This paper reports preliminary experimental and numerical efforts towards obtaining steam-water relative, permeability and capillary pressure functions under steady-state and adiabatic conditions. In the experimental direction, steady-state nitrogen-water relative permeability experiments were conducted in a Berea sandstone core as a first step. Results obtained from this type of experiment will be compared to those from steam-water relative permeability experiments in order to explore the importance of phase change and heat transfer. Using a high resolution X-ray computer tomography (CT) equipment, saturation distributions along the core were obtained and relative permeabilities for both nitrogen and water were calculated. Preliminary results showed strong end effects for the core length and total flow rate used in the experiment, which therefore suggested either to use of a longer core or to work at a higher total flow rate. Along with the experiment, numerical simulations of simultaneous injection of steam and water into a core were also carried out by using a commercial thermal simulator. At steady-state flow conditions, effects of steam quality and total injection rate on saturation profiles were investigated. Numerical simulation results suggested a core length of 38.10 cm for a flat saturation profile region to exist under typical experimental conditions.
Recycling of a starch-based biodegradable polymer (2002)

A new starch-based polymeric system, ZI1OU from Novamont, mainly composed of starch and polycaprolactone, was reprocessed several times in an extruder to investigate the recyclability of this biodegradable polymer. A previous investigation of the thermomechanical degradation in a mixer has been also done. The degradation is mostly due to the thermal stress but the presence of the mechanical stress strongly increases the degradation kinetic. During melt processing two concurrent processes take place: the first is the degradation, i.e. the breaking and shortening of polymeric chains, mostly occurring in the PCL phase; the second is the formation of some crosslinked structure in the starch phase. The rheological and mechanical properties, measured on samples subjected to repetitive extrusion operations carried out in a single screw extruder, clearly indicate that, in the adopted processing conditions, no significant modifications are observed. Only after five extrusions some decrease of these properties was measured.
Little Chin-Chin : Keep Your Chin Up (1936)

https://digitalcommons.library.umaine.edu/mmb-vp-copyright/8150/thumbnail.jpg
Photooxidation of the propylene-NOx-air system studied by long-path Fourier transform infrared spectrometry (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotooxidation of the propylene-NOx-air system studied by long-path Fourier transform infrared spectrometryHajime. Akimoto, Hiroshi. Bandow, Fumio. Sakamaki, Gen. Inoue, Mikio. Hoshino, and Michio. OkudaCite this: Environ. Sci. Technol. 1980, 14, 2, 172–179Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/es60162a007https://doi.org/10.1021/es60162a007research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<i>SMN1</i> gene duplications are associated with sporadic ALS (2012)

Our data provide firm evidence for a role of common SMN1 duplications in ALS, and raise new questions regarding the disease mechanisms involved.
Increased procollagenase activating angiogenic factor in the vitreous humour of oxygen treated kittens. (1988)

Previous studies have demonstrated an increase in a low molecular weight angiogenic factor (ESAF) present in the retinae of kittens with oxygen induced retinopathy. The present paper describes differences in the quantity of ESAF extracted from the vitreous humour of control and oxygen treated animals and proposes a mechanism for the induction of intravitreal neovascularisation.
Controlling polarization twisting of light resulting from surface plasmon interactions with threefold symmetric nanostructures (2009)

The design and architecture of nanostructures for the purpose of controlling and manipulating surface plasmon polariton (SPP) dynamics is currently a focal point of research. It is driven by the predicted impact that plasmonic components will have on many future technologies. In this paper, we demonstrate the first instance of plasmon-mediated polarization reorientation observed in the far field with no associated re-emission directional change. Specifically, it is demonstrated that, as a result of the interaction between SPPs and tailor-designed nanostructures of threefold symmetry characteristics, a polarization twisting of the SPP-mediated reradiated light is attained. It is shown that the dynamics of such an interaction can be controlled externally, enabling active control of the outgoing polarization orientation. In order to further understand the origin of the processes involved, Green's function based simulations of the interactions are presented and confirm that the origin of the polarization twisting can be explained via asymmetrical in-plane SPP scattering.
Performance Evaluation of Packet Processing Architectures Using Multiclass Queuing Networks (2006)

Modern real-time systems consist of complex parallel and heterogeneous architectures. Early design decisions, such as the partitioning of functionality onto architecture building blocks and the choice of algorithms, have a large impact on the quality of the resulting platform. In order to support the designer during this concept phase, we have developed our performance evaluation framework SystemQ. In this paper, we demonstrate why multiclass queuing networks as used by SystemQ are a natural abstraction for evaluating network processing platforms. In particular, we reveal the impact of scheduling policies on the quality-of-service, such as the residence time of network traffic in the system. For the same stimuli, the packet latency can vary by more than one order of magnitude if only one queuing discipline in the system is modified.
The effect of short-term labelling in (3H) thymidine on the viability of mouse blastomeres: alone and in combination with unlabelled blastomeres. (1976)

A method of labelling 8-cell-stage mouse blastomeres with [3H]thymidine is described, which allows them to be followed to the late blastocyst stage and is compatible with normal postimplantation development. However, the [3H]thymidine does affect the postimplantation vigour of the cells when placed in competition with unlabelled cells in blastomere aggregates. This suggests that caution should be used in interpreting results using [3H]thymidine as a label for early mammalian cells.
<title>Argon laser vascular tissue fusion: current status and future perspectives</title> (1991)

Tissue fusion by laser energy is an intriguing and very promising new applications for laser technology. In comparison to using high laser energy to ablate tissue as in the angioplasty application, laser tissue fusion is possible in any soft tissue by delivering appropriate low levels of energy to the opposed tissue surfaces. This technology is particularly appealing for vascular applications in making sutureless blood vessel anastomosisand for securing the endpoints of endarterectomies and dissection planes. Although there have been limited evaluations of this technology, the preliminary experimental and clinical data is very promising for continued development and application. Vascular tissue fusion or welding by lasers is performed by directing a low energy beam at the opposed edges of the repair. The energy is applied by moving the beam back and forth along the fusion line or, in certain cases, by delivering the energy in "spot" applications. Vessel sealing is apparent in the majority of fusions to the trained eye, as is nonunion caused by inadequate energy delivery, or tissue coagulation or vaporization from excessive energy exposure. Laser repairs can be fashioned in time intervals comparable to or slightly longer than those required for suture repairs. Precision of tissue apposition at the time of fusion is a critical parameter which affects the rate of healing and tensile strength of tissue welds. A gap between the vessel edges or blood at the interface compromises weld strength.
Calcium Transport by Cardiac Sarcoplasmic Reticulum (1981)

The response of calcium transport to halothane by the cardiac sarcoplasmic reticulum (SR) was investigated to determine whether the SR is a site for anesthetic depression of the myocardium. It was observed that halothane could both stimulate (by 800%) and inhibit (by 500%) calcium transport. The varied effects are dependent on adenosine triphosphate (ATP) and calcium and hydrogen ion concentrations. At 2.25% halothane, the Km for ATP is decreased from 2.35 to 0.712 mM and Vmax is decreased from 292 to 149 nmoles/mg/2 min. It was found that the steady-state level of calcium in the SR was decreased by 33% by halothane at pH 6.9, whereas halothane had no effect at pH 7.3. It was concluded that the SR is an unlikely site of halothane-induced myocardial depression in the normal heart when substrate concentrations and pH are maintained. In the ischemic heart in which the pH and substrate concentration have decreased, the interaction of halothane with the SR might contribute to a decrease in Ca2+ for contraction.
Factors affecting the float performance of the negative plate of the lead-acid battery (2003)

It has been demonstrated that several factors play a role in determining the behavior of the negative plate of the lead-acid battery. It is concluded that, when a battery is intended for float applications, especially in telephone central offices where the degree of reliability required is high, special attention must be paid to all of the factors which can affect the polarization behavior of the negative plate and, consequently, its float performance. Some of these factors are understood at a level which permits their control, specifically, the addition of platinum and, to a lesser extent, the nature of the separator. However, many questions regarding the expander and its interaction with the oxide remain to be resolved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pathophysiology of Psoriasis (1977)

Psoriasis is a disease characterized by benign but unrestricted epithelial growth. The molecular pathophysiology of this unregulated growth has been discussed. A better understanding of the role of the cell surface, cyclic nucleotides, arachidonic acid-prostaglandin metabolism, and polyamines in psoriasis may clarify our understanding of this disease and produce clues pertinent to a general understanding of growth regulation.
Deep Level Impurities in Germanium and Silicon: Low Temperature Passivation or Removal Techniques (1984)

Deep level impurities and defects in high-purity germanium and silicon radiation detectors are often the cause of degraded spectral resolution. Exposure of the semiconductor diode to a low pressure hydrogen plasma may neutralize the electrical activity of a wide range of line and point defects and contaminating impurities, such as copper in Ge and gold in Si. The efficiency and thermal stability of this technique are discussed. The application of other novel methods of defect removal, such as the room temperature drifting of charged defects out of the depletion region under the action of the electric field in a diode, and the recombination enhanced annealing of radiation damage centers in Ge is also discussed.
Morphological Simulation of the Roughness Transfer on Steel Sheets (1996)

Le transfert de rugosit a lieu lors de la dernire tape de laminage des tles en acier. L'un des buts de l'opration consiste modifier la surface de la tle afin de lui donner une morphologie de surface qui conditionne certaines proprits de mise en 0153uvre de la tle. Un modle de simulation morphologique, bas sur des essais exprimentaux, est propos pour prvoir la topographie de surface de la tle connaissant celle du cylindre. Des rsultats de prvision sont montrs et compars des essais rels de transfert de rugosit.
The impact of singlet oxygen on lipid oxidation (2007)

Abstract Oxidation plays a fundamental role in the reduction of the quality of fats, oils and many other principal ingredients in food or animal feed. A significant amount of research data is available on the impact of autoxidation caused by the most abundant and stable form of oxygen: triplet oxygen ( 3 O 2 ). An alternative oxidation process occurs when lipids are exposed to a light source, even at low temperatures. Many molecules are able to absorb energy from light after which this energy is transferred to an oxygen molecule. This process leads to the conversion of the most abundant triplet oxygen into the more reactive singlet oxygen ( 1 O 2 ). Both types of oxygen react very differently with lipids and other nutrients due to the dissimilarity in their fundamental chemical structure. This allows researchers to study the different possible oxidation pathways and consequently to develop potential strategies to delay oxidation for the improvement of shelf life.
Reflection and transmission of Lamb waves at an imperfect joint of plates (2013)

The reflection and transmission of Lamb waves at an imperfect joint of plates are analyzed numerically by the modal decomposition method and the hybrid finite element method. The joint is modeled as a spring-type interface characterized by distributed normal and tangential stiffnesses. The analysis is focused on a low-frequency range where the lowest-order symmetric and antisymmetric Lamb waves are the only propagating modes. The frequency-dependent reflection and transmission characteristics of these Lamb modes are computed for different interfacial stiffnesses, together with the generation behavior of localized, non-propagating higher-order Lamb modes. As a result, S0-mode Lamb wave is shown to exhibit the reflection and transmission characteristics which are monotonically frequency-dependent. On the other hand, A0-mode Lamb wave shows complicated and non-monotonic frequency dependence in the reflection and transmission characteristics. The obtained Lamb wave characteristics are discussed in the light of approximate one-dimensional models constructed based on classical plate theories. As a result, the reflection and transmission coefficients of S0-mode Lamb wave are accurately reproduced by a simple model of longitudinal wave in thin plates, while those of A0-mode Lamb wave are well described by the Mindlin plate model of flexural wave. It is also shown that stiffness reduction at the corners of the contacting edges of plates has only minor influence on the reflection and transmission characteristics.
ChemInform Abstract: Synthesis and Conformational Analysis of α,α‐Difluoroalkyl Heteroaryl Ethers. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.