gebhart/patrepeval huggingface dataset:
[Mutagenesis of the human histamine H1 receptor and design of new antihistamine agents]. (1996)

The binding cavity of histamine and histamine antagonists is explored using site directed mutagenesis of the human histamine H1 receptor and the amino acids involved in ligand binding are identified. Whereas Asp107 and Phe199 are important for both agonists and antagonists, two additional amino acids (Asn198 and Trp103) are required for efficient histamine binding. The binding site of antagonists is best defined as resulting from a strong ionic bond to Asp107, an orthogonal interaction between one of the aromatic rings with Phe199, and probably a hydrophobic interaction between the second aromatic ring and the lipophilic amino acids of the upper part of TMIV and TMV. This is consistent with structure-activity data of most described antagonists.
Gamma-Ray Astrophysics: A New Look at the Universe (1978)

Progress in gamma-ray astronomy has been very encouraging in recent years. These observations provide the most direct means of studying the largest transfer of energy occurring in astrophysical processes: the dynamic effects of the energetic charged cosmic-ray particles, element synthesis, and particle acceleration. Gammaray astronomical observations also find important application in studies of the development of the planets from the primitive solar nebula and of the nature of high-energy processes in the sun's atmosphere and their relation to the basic problems of solar activity.
Comparison of effects of neurotensin and fat on pancreatic stimulation in dogs (1983)

In six conscious dogs with esophageal, gastric, and pancreatic fistulas, the effects of intravenous infusion of neurotensin and intraduodenal instillation of sodium oleate on gastric and pancreatic secretion were determined under basal conditions and after exogenous (secretin and cholecystokinin octapeptides) or endogenous stimulants (feeding and duodenal acidification). Neurotensin given intravenously in graded doses (1.5-200 pmol . kg-1 . min-1) to fasted dogs produced a dose-dependent stimulation of pancreatic bicarbonate and protein secretion reaching, respectively, about 18 and 100% of maximal responses to secretin and cholecystokinin octapeptide (CCK). Duodenal oleate in graded doses (0.5-16 mmol/h) resulted in a similar pattern of bicarbonate and protein secretion but increased plasma neurotensin only to about 10% of that achieved with infusion of exogenous neurotensin producing an equal rate of pancreatic secretion. Neurotensin, like oleate, potentiated the action of secretin and CCK on pancreatic bicarbonate and had additive effects on protein response to these secretagogues. Both neurotensin and oleate increased pancreatic response to liver extract meal kept in the stomach at constant pH (5.5) and the response to sham feeding but decreased the response to ordinary feeding, probably due to the inhibition of gastric acid secretion and reduction of duodenal acidification. Neurotensin given intra-arterially directly to the pancreas or to isolated intestinal segment increased dose dependently the blood flow and oxygen consumption without affecting general circulation. We conclude that 1) neurotensin mimics the pancreatic secretory effects of intestinal fat, 2) neurotensin may contribute in part to fat-induced stimulation of the pancreatic secretion, and 3) the secretory effects of neurotensin are accompanied by a marked stimulation of intestinal and pancreatic circulation and metabolism.
Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies (2016)

Considerable scope exists to vary the physical and chemical properties of nanoparticles, with subsequent impact on biological interactions; however, no accelerated process to access large nanoparticle material space is currently available, hampering the development of new nanomedicines. In particular, no clinically available nanotherapies exist for HIV populations and conventional paediatric HIV medicines are poorly available; one current paediatric formulation utilizes high ethanol concentrations to solubilize lopinavir, a poorly soluble antiretroviral. Here we apply accelerated nanomedicine discovery to generate a potential aqueous paediatric HIV nanotherapy, with clinical translation and regulatory approval for human evaluation. Our rapid small-scale screening approach yields large libraries of solid drug nanoparticles (160 individual components) targeting oral dose. Screening uses 1 mg of drug compound per library member and iterative pharmacological and chemical evaluation establishes potential candidates for progression through to clinical manufacture. The wide applicability of our strategy has implications for multiple therapy development programmes.
Charge-Transfer Magnetoelectrics of Polymeric Multiferroics (2014)

The renaissance of multiferroics has yielded a deeper understanding of magneto-electric coupling of inorganic single-phase multiferroics and composites. Here, we report charge-transfer polymeric multiferroics, which exhibit external field-controlled magnetic, ferroelectric, and microwave response, as well as magneto-dielectric coupling. The charge-transfer-controlled ferroic properties result from the magnetic field-tunable triplet exciton which has been validated by the dynamic polaron-bipolaron transition model. In addition, the temperature-dependent dielectric discontinuity and electric-field-dependent polarization confirms room temperature ferroelectricity of crystalline charge-transfer polymeric multiferroics due to the triplet exciton, which allows the tunability of polarization by the photoexcitation.
Experiment and Simulation on the Reduction of the Semiconductor Optical Amplifier Optoelectronic Switching Time (2002)

A technique to reduce the Semiconductor Optical Amplifier electro-optic switching times is implement. The technique, called PISIC (pre-impulse-step injected current), presented a reduction of the SOA switching times from almost 2ns (simple-step current response) to little more than 200ps (step with pre-pulse response). Forecasts done through simulations, using optimized values of current step and prepulse, showed even a faster optical switch response, with switching time reduction to values around 10 ps.
Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of the Blood Markers Hyaluronic Acid, Orosomucoid, and Keratan Sulfate (1990)

Single analyses of peripheral blood of rheumatoid arthritis (RA) patients showed a significant reduction in the mean value for keratan sulfate (KS) compared with that in control subjects, but the mean value for orosomucoid (OM) was elevated compared with that in control subjects. Some RA patients displayed highly elevated levels of hyaluronic acid (HA), while others exhibited normal levels. There was a significant inverse correlation between OM and KS content in RA patients, as well as a direct correlation between HA and OM. In longitudinal studies of RA patients, parallel changes in OM and HA and inverse changes between KS and OM or HA were commonly observed. Clinical analyses revealed that there was an inverse correlation between KS and morning stiffness, and direct correlations between the number of tender joints and HA, and between HA or the erythrocyte sedimentation rate and the number of joints with effusions. The reason(s) for the inverse correlation between KS and OM as an index of systemic inflammation remains to be established. Circulating HA represents an index of joint inflammation, for which a marker has not been previously available.
Effect of lateral lymph node dissection on the quality of life and genitourinary function after neoadjuvant chemoradiotherapy for rectal cancer (2021)

The overall quality of life and urinary function after total mesorectal excision does not differ significantly when lateral lymph node dissection is performed as well.
Suppression of amyloid‐β production by 24S‐hydroxycholesterol <i>via</i> inhibition of intracellular amyloid precursor protein trafficking (2013)

Cholesterol can be converted to 24S-hydroxycholesterol (24SOHC) by neuronal cholesterol 24-hydroxylase. In mouse models of Alzheimer's disease (AD), increasing 24SOHC levels reduced AD pathology. However, mechanisms underlying the effects of 24SOHC on amyloid-β (Aβ) production have remained unclear. Here we report that 24SOHC treatment reduces Aβ production and increases endoplasmic reticulum (ER)-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-SY5Y cells and CHO cells stably expressing human APP. Treatment with 1-10 μM 24SOHC (equivalent to the concentrations detected in human brain homogenates) diminished Aβ production (IC50=4.6 μM for Aβ40) without affecting secretase activities. To evaluate the intracellular APP transport, we established an in vitro vesicle formation assay. We found that APP budding via COPII vesicles was diminished by 70% in 24SOHC-treated cells. The proteomics and immunoblotting analysis revealed that 24SOHC induced the expression of glucose-regulated protein 78 (GRP78), an ER chaperone, through unfolded protein response pathways, and enhanced the formation of the APP/GRP78 complex. Knockdown of GRP78 diminished the inhibitory effects of 24SOHC on Aβ production. These results suggest that 24SOHC down-regulates APP trafficking via enhancement of the complex formation of APP with up-regulated GRP78 in the ER, resulting in suppression of Aβ production.
Ocular distribution and toxicity of intravitreal injection of triamcinolone acetonide in normal equine eyes (2008)

There was no evidence of overt toxicity from intravitreal TA in normal horses and a single intravitreal injection resulted in TA ocular levels for 21 days. However, the risk for bacterial infections with intravitreal injection or anterior chamber aspirations in horses is high. Use of topical and systemic antibiotics after injection is recommended.
The role of development in locally-oriented visual perception: an investigation spatial contrast sensitivity in Autism Spectrum Disorder (2014)

Autism Spectrum Disorder is characterized by a unique, visual perceptual profile that is best defined by an often- superior ability to process non-social, or elementary, visual information when a local processing strategy is advantageous (Mottron et al. 2006, Behrmann 2006). Several studies suggest that locally-biased perception in ASD may originate at early stages of visual processing, reflected by an increased sensitivity to high-spatial frequency information (Keita, Guy et al. (in review), de Jonge et al. 2007, Jemel et al. 2010). The bulk of these studies, however, have been conducted in adults and older adolescents, neglecting the role of development. It is therefore unclear if locally-oriented perception in ASD emerges early in development and moreover, when exactly it manifests from childhood through to adulthood. The aim of the present study was therefore to examine the development of low-level visuo-spatial perception in ASD in school-aged children and adolescents. Spatial resolution was assessed across three different age groups (i.e. 6-9, 10-12 and 13-15 years), using luminance-defined, sinusoidal gratings defined by different spatial frequencies (0.5, 1, 2, 4, 8 & 16 cycles per degree). Detection thresholds were derived using a two-alternative temporal forced choice paradigm. Contrast sensitivity functions were then defined for each age group. Preliminary analyses failed to reveal a significant group difference in sensitivity. Only expected differences in sensitivity for SF condition and age group emerged. Our current findings indicate that group differences in sensitivity might only be apparent in late adolescence and early adulthood. These results warrant further exploration of the role of experience-dependent modification of neural mechanisms mediating the response properties of early visual processing in ASD. Meeting abstract presented at VSS 2014
Intravenous Alteplase in Ischemic Stroke Patients not Fully Adhering to the Current Drug License in Central and Eastern Europe (2012)

Our findings show that patients not fully adhering to the European license are not at increased risk of symptomatic intracranial haemorrhage but achieve less favorable outcome. Some contraindications appear more redundant than others. However, the final conclusions about safety and effectiveness should be based on the results of ongoing randomized trials.
Model evaluation of marine primary organic aerosol emission schemes (2012)

Abstract. In this study, several marine primary organic aerosol (POA) emission schemes have been evaluated using the GEOS-Chem chemical transport model in order to provide guidance for their implementation in air quality and climate models. These emission schemes, based on varying dependencies of chlorophyll a concentration ([chl a]) and 10 m wind speed (U10), have large differences in their magnitude, spatial distribution, and seasonality. Model comparison with weekly and monthly mean values of the organic aerosol mass concentration at two coastal sites shows that the source function exclusively related to [chl a] does a better job replicating surface observations. Sensitivity simulations in which the negative U10 and positive [chl a] dependence of the organic mass fraction of sea spray aerosol are enhanced show improved prediction of the seasonality of the marine POA concentrations. A top-down estimate of submicron marine POA emissions based on the parameterization that compares best to the observed weekly and monthly mean values of marine organic aerosol surface concentrations has a global average emission rate of 6.3 Tg yr−1. Evaluation of existing marine POA source functions against a case study during which marine POA contributed the major fraction of submicron aerosol mass shows that none of the existing parameterizations are able to reproduce the hourly-averaged observations. Our calculations suggest that in order to capture episodic events and short-term variability in submicron marine POA concentration over the ocean, new source functions need to be developed that are grounded in the physical processes unique to the organic fraction of sea spray aerosol.
Electrical Impedance Spectroscopy (EIS) characterization of saline solutions with a low-cost portable measurement system (2018)

Electrical Impedance Spectroscopy (EIS), a powerful technique used for wide range of applications, is usually carried out by means of benchtop instrumentation (LCR meters and ìmpedance analyzers), not suited for in-the-field measurements performed outside a laboratory. In this paper a new portable electronic system for EIS on liquid and semi-liquid media is presented that is capable to produce an electrical fingerprint of the sample under investigation. The proposed system was used for the characterization of four different saline solutions (NaCl, Na2CO3, K2HPO4 and CuSO4). A multi-frequency approach, based on the measurement of maximum value of the impedance imaginary component and its corresponding frequency, was tested for the first time to discriminate different saline solutions. The results show that the proposed method is capable to discriminate the different solutions and to measure the concentration (R2 = 0.9965) independently of the type of saline solution.
Iron‐Catalyzed Cyclotrimerization of Terminal Alkynes by Dual Catalyst Activation in the Absence of Reductants (2017)

Abstract Catalyzing C−C bond‐forming reactions with earth‐abundant metals under mild conditions is at the heart of sustainable synthesis. The cyclotrimerization of alkynes is a valuable atom‐efficient reaction in organic synthesis that is enabled by several metal catalysts, including iron. This study reports an effective iron‐catalyzed cyclotrimerization for the regioselective synthesis of 1,2,4‐substituted arenes (1 mol % catalyst, toluene, 20 °C, 5 min). A dual activation mechanism (substrate deprotonation, reductive elimination) renders the simple Fe II precatalyst highly active in the absence of any reductant.
Enhanced linear dynamic range of asymmetric Fabry-Pe/spl acute/rot modulator/detector (2006)

An InGaAsP multiple-quantum-well asymmetric Fabry-Pe/spl acute/rot modulator/detector has been developed for radio-over-fiber systems. The measured bandwidth is more than 6 GHz and the total insertion loss is 7.1 dB. The property of nonlinearity and spurious-free dynamic range (SFDR) has been studied theoretically. By optimizing the operation optical wavelength and bias voltage based on the numerical simulation, fifth-order nonlinearity dominates the intermodulation distortion and an SFDR of 101 dB/spl middot/Hz/sup 4/5/ has been achieved experimentally.
Nitinol spring rod dynamic stabilization system and Nitinol memory loops in surgical treatment for lumbar disc disorders: short-term follow up (2007)

The Nitinol BioFlex dynamic stabilization system can achieve stabilization and simultaneously allow physiological movement, which can in turn decrease the degeneration of adjacent segments. When used with PLIF, the fusion rate can be expected to increase. The flexible Nitinol shape memory loop, a posterior dynamic stabilization device, is an adequate tension band that displays strength similar to the posterior ligamentous structures. In combination with PLIF at the main lesion, the BioFlex system or the Nitinol memory loop can provide posterior dynamic stabilization to the transitional upper or lower segments, enhance the fusion rate, reduce the adjacent segment degeneration, and provide dynamic stabilization of the spine.
A novel quasi-one-dimensional zig-zag platinum atom chain in K1.75Pt(CN)4.1.5H2O. A neutron diffraction study (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel quasi-one-dimensional zig-zag platinum atom chain in K1.75Pt(CN)4.1.5H2O. A neutron diffraction studyKeith D. Keefer, Donald M. Washecheck, Nancy P. Enright, and Jack M. WilliamsCite this: J. Am. Chem. Soc. 1976, 98, 1, 233–234Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/ja00417a038https://doi.org/10.1021/ja00417a038research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reserpine Treatment of Raynaudʼs Disease (1978)

Six patients with primary Raynaud's disease were investigated with magnification hand arteriography, measurement of finger systolic pressure and response to a newly devised local cooling test. They were treated with reserpine 0.5 mg injected into the brachial artery, and the clinical effects were followed by a scoring system and by the change in digital arterial tone during local cooling. The latter was registered as the change in systolic finger blood pressure measured indirectly by a finger-plethysmograph during stepwise decrease in finger temperature, until at a critical temperature complete closure of the digital arteries occurred. Shortly after injection the clinical condition improved, and closure of the digital arteries during local cooling was impeded. But within a week the cooling test showed a transient deterioration with closure of the digital arteries at the same or a somewhat higher temperature than before the reserpine injection. The clinical score followed this trend. According to animal experiments the shortlasting vascular effect of reserpine on primary Raynaud's disease might be due to depletion of the sympathetic nerve terminals for norepinephrine.
Theoretical And Experimental Studies Of The Effects Of Rapid Thermal Annealing In GaAs∕AlGaAs Quantum Dots Grown By Droplet Epitaxy (2011)

We fabricated low‐density GaAs/AlGaAs quantum dots for single photon source by droplet epitaxy. We investigated the emission energies of the dots and underlying superlattice by using photoluminescence and cathodoluminescence measurements. By forming a mesa etched structure, we distinguished the transitions from the superlattice and the dots. And we calculated the diffusion length in this system from the peak shift of the superlattice, and applied the diffusion to the dots to investigate the emission energy shift of the QDs.z
A Survey of Energy Efficient Resource Management Techniques for Multicell Cellular Networks (2013)

This paper surveys the recent findings in the area of energy efficient radio resource management in cellular networks. The primary objective is to identify and evaluate the key techniques that have the highest energy saving potential to be developed in the context of Green Networks while serving as a guideline for future research endeavours. The focus of the paper is targeted towards multicell networks which are composed of multiple BSs co-existing in the same area sharing the available radio resources. Due to this, greater emphasis is given towards the techniques that take inter-cell interference (ICI) into account while allocating the resources and, in the process, maximize the energy efficiency (EE). The resource management solutions presented in the paper are classified under three network domains namely homogeneous, heterogeneous, and cooperative networks. Furthermore, the analytical techniques for characterizing the EE of multicell networks are discussed in terms of the stochastic geometry framework. Finally, the paper outlines the current challenges and open issues in the area of energy efficient resource management for multicell cellular networks.
Control of the Borer Complex on Almonds, 1984 (1985)

Abstract Tests were conducted in a commercial almond (4th leaf) orchard in Livingston, CA. Six treatments of insecticides combined with various paint-water mixtures and a control were replicated 10 times using a randomized complete block design. Each replicate consisted of an individual tree. Trees were inspected before the application. Only trees with active feeding sites, indicated by frass piles, were included in the study. Materials were applied to the trunk from the ground to the secondary branches with a Hudson hand-held sprayer on 6 Jun. All materials were applied as 9.4 gal of spray mixture per acre. After application, trees were inspected at weekly intervals from 12 Jun through 7 Sep, and the number of frass piles was counted and removed. Also, for a 2 man-hour search period on 22 May and at approximately weekly intervals from 16 Jun through 7 Sep, larvae were extracted for identification from active feeding sites in trees outside the test plot.
Experimental Determination of Damping in Rolling Bearing Joints (1994)

Equivalent radial stiffness and damping coefficients of ball bearing joints are identified from a bearing test rig through measured linear frequency domain transfer functions. Common least square techniques are used to curve fit analytical transfer functions of a MDOF-mechanical model of the test rig to the measured transfer functions. Both, the damping caused within the dry Hertzian contacts between the balls and the raceways and the damping within the bearing to housing interface are determined separately. A substantial interface damping is observed that may explain significant deviations between theoretical and experimental results stated in the literature.