gebhart/patrepeval huggingface dataset:
Erythropoietin-induced cellular differentiation requires prolongation of the G1 phase of the cell cycle. (1995)

Erythropoietin (EPO), like many other hematopoietic growth factors, can induce either growth or differentiation of hematopoietic cells. Little is known about the molecular basis of this cellular decision, in part because of a paucity of cell lines in which these two phenomena can be dissociated. Ectopic expression of the EPO receptor (EPO-R) in Ba/F3, a murine interleukin 3 (IL-3)-dependent progenitor cell line, confers EPO-dependent cell growth. In these cells (Ba/F3-EPO-R), EPO also induces beta-globin mRNA, a specific marker of erythroid differentiation. Here we show that the induction of erythroid differentiation by EPO requires a delay in cell growth and a prolongation of the (G1) phase of the cell cycle. Interestingly, this effect on G1 prolongation was concentration dependent. At low EPO concentrations (0.05-0.1 unit of EPO per ml; 1 pM EPO = 0.01 unit of EPO per ml), EPO prolonged G1 and induced differentiation; at high concentrations (0.5-10.0 units per ml), EPO shortened G1 and preferentially stimulated growth. IL-3 stimulated Ba/F3 growth but not differentiation at all growth factor concentrations ranging from 0.1 to 500 pM. Moreover, IL-3 suppressed EPO-induced beta-globin induction in a dose-dependent manner. This suppression correlated with the shortening of G1 by IL-3. Taken together, these data demonstrate distinct effects of EPO and IL-3 and a balance between erythroid growth and differentiation that is cell cycle dependent.
Insect Abundances on Tomatoes and Squash Mulched with Aluminum and Plastic Sheetings1 (1968)

Journal Article Insect Abundances on Tomatoes and Squash Mulched with Aluminum and Plastic Sheetings Get access D. O. Wolfenbarger, D. O. Wolfenbarger Sub-Tropical Experiment Station, University of Florida, Homestead Search for other works by this author on: Oxford Academic PubMed Google Scholar W. D. Moore W. D. Moore Sub-Tropical Experiment Station, University of Florida, Homestead Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 61, Issue 1, 1 February 1968, Pages 34–36, https://doi.org/10.1093/jee/61.1.34 Published: 01 February 1968 Article history Accepted: 12 September 1967 Published: 01 February 1968
Evaluating the cytotoxicity of ionic liquids using human cell line HeLa (2004)

This paper presents cytotoxicity data of selected imidazolium ionic liquids evaluated in vitro on the human tumor cell line HeLa. It was found that for 1-n-butyl-3-methylimidazolium entities the toxicity depends strongly on the associated anion; EC50 values are lowest for tetrafluoroborate. No direct dependence of the reduced effect concentration was found on elongating the short, methyl chain to ethyl or n-hexyl. Only for the ionic liquid with an n-decyl chain, the longest one studied, did higher hydrophobicity result in a EC50 one order of magnitude lower than that obtained with the n-butyl entity. The effect concentrations of imidazolium ionic liquids in the HeLa system used are lower than the values obtained for conventional organic solvents such as dichloromethane, toluene or xylene.
Improving the Prediction of Processing Bean Maturity Based on the Growing-degree Day Approach (2000)

Four snap bean ( Phaseolus vulgaris L.) cultivars, Goldrush, Teseo, Labrador, and Flevoro, were grown in irrigated fields of southern Quebec between 1985 and 1998. Data on phenology collected from these fields were used to determine which base temperature would best predict time from sowing to maturity. The optimal base temperature was 0 °C for `Goldrush', `Teseo', and `Labrador' and 6.7 °C for `Flevoro'. Adjusting different base temperatures for intermediate developmental stages (emergence, flowering) did not improve the prediction model. All years for a given cultivar were then used to determine the base temperature with the lowest coefficient of variation (CV) for predicting the time from sowing to maturity. A common base temperature of 0 °C was selected for all cultivars, since `Flevoro' was not very sensitive to changes in base temperature. This method improved the prediction of maturity compared with the conventional computation growing-degree days (GDD) with a base of 10 °C. For the years and cultivars used in this study, calculating GDD with a base of 0 °C gave an overall prediction of maturity of 1.7, 1.5, 2.0, and 1.4 days based on average absolute differences, for `Flevoro', `Goldrush', `Teseo', and `Labrador', respectively.
EPHB receptor signaling in dendritic spine development (2004)

Dendritic spines are small bulbous protrusions on the surface of dendrites that serve as principle postsynaptic targets for excitatory synapses (1-3). Structural modifications of dendritic spines have been implicated as a cellular basis for learning and memory. Morphological abnormalities of spines are observed in some neurological diseases such as mental retardation and schizophrenia (4). Thus, studies on the morphological regulation of dendritic spines could have strong relevance to our understanding of the molecular mechanisms of the higher brain function and the pathophysiology of neurological disorders. Here we review recent progress on the role of the cell surface heparan sulfate proteoglycan syndecan-2 and ephrin-Eph signaling in dendritic spine development. Information from these new developments suggests a model in which cell surface ephrin-Eph signaling induces clustering of syndecan-2 and recruitment of cytoplasmic molecules, which leads to localized actin polymerization via Rho family GTPases, N-WASP, and the Arp2/3 complex.
Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs (2004)

There has been no published indepth systematic evaluation of the best approaches to symptom evaluation in gastro-oesophageal reflux disease (GORD). A two day international multidisciplinary workshop was therefore held in Marrakech, Morocco, in September 2002 to address these issues. The aim of the workshop was to critically review the data regarding the reliability, processes, and priorities for symptom evaluation in GORD patients. The workshop was designed to give outputs that could be readily reported and to arrive at specific recommendations on best practice in symptom evaluation in reflux disease.
Development of Software Tool for Cellular Structure Integration for Additive Manufacturing (2016)

Cellular structure is one of the solutions for producing parts in a more resource efficient way by reduction of material and time used. Recent advances in Additive Manufacturing (AM) have enabled these complex structures to be built while it is almost impossible by subtractive manufacturing. However, modelling process is resource intensive and time consuming due the geometrical complexity. This article presents development of a software tool for rapidly modelling the structures with prefabrication hybrid geometric modelling (P-HGM) method based on a hybrid B-Rep approach. The structure will be integrated to the specified volume in the base 3D model with polygonal approach. Open-source libraries, including OpenCascade Technology (OCCT) and Visualization Toolkits (VTK), are used.
A criterion for arrest of a threading dislocation in a strained epitaxial layer due to an interface misfit dislocation in its path (1990)

In a strained layer grown epitaxially on a substrate, the motion of a dislocation on any particular glide plane in the layer can be influenced by the presence of dislocations on other glide planes. The focus here is on the glide of a dislocation extending from the free surface of the layer to the layer-substrate interface, the so-called threading dislocation. A general definition of driving force for glide of a threading dislocation in a nonuniform stress field is adopted to calculate the driving force on a threading dislocation due to an encounter with an interface misfit dislocation on an intersecting glide plane. The result is examined in detail for the case of cubic materials, taking into account different combinations of Burgers vectors. The analysis makes it clear that the misfit dislocation forces the threading dislocation to glide through a channel of width less than the full layer thickness. A blocking criterion is proposed, based on the presumption that blocking will occur if the channel width is less than the critical thickness for the local reduced strain. The results indicate that this effect can be significant in blocking the glide of a threading dislocation, depending on the mismatch strain magnitude and the layer thickness.
A SUPPLEMENT TO THE ANNOTATED LIST OF OPISTHOBRANCHS FROM SAN-LUIS-OBISPO COUNTY CALIFORNIA (1970)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
The position location system using IS-95 CDMA networks (2002)

The position location systems have become a hot issue over the past few years in wireless communication. So far, many people have thought of the Global Positioning System (GPS) as position location system. However, we can use the code division multiple access (CDMA) networks of the position location system. Two systems considered for position location system in CDMA networks are direction finding and ranging. We have examined the position location system by considering the direction finding and ranging system and analyzed the performance of both systems. We also propose a position location system for mitigation of the non-line of site (NLOS) propagation error in IS-95 CDMA networks. We show that the proposed position location system improves the performance of the NLOS ranging error mitigation.
Interaction of Electromagnetic and Gravitational Waves in the Weak and Short Wave Limit (1975)

The interaction and the transformation of electromagnetic and gravitational waves in an external electromagnetic field are analyzed. The Einstein-Maxwell field equations are used, and the waves are assumed to be weak and have a short wavelength. The electromagnetic and gravitational potentials are assumed to be sums of potentials of the background and of the wave. In the limit of weak and short wave, the wave potentials can be separated uniquely from the curved background potentials. When an electromagnetic field exists, the energy current densities of two waves may change along a ray, while the total current density remains constant along it. The differential equations governing the interaction of the two waves are identical with the equations derived from the theory of singular surface.
A power-aware, best-effort real-time task scheduling algorithm (2004)

In this paper, we present a power-aware, best-effort real-time task scheduling algorithm called PA-BTA that optimizes real-time performance and power consumption. The algorithm considers a timeliness model where task timing constraints are described using Jensen's (1992) benefit functions and a system-level power model. We propose a metric called "energy and real-time performance grade" (ERG) to measure real-time performance and power consumption in a unified way. Since the scheduling problem is NP-hard, PA-BTA heuristically computes schedules to maximize ERG, incurring a worst-case computational cost of O(n/sup 2/). Our simulation results indicate that the algorithm performs close to the optimal algorithm and better than other algorithms considered in the study.
ELECTRICALLY CONDUCTIVE CONCRETE (1978)

The transition-metal-catalysed cross-coupling reaction has established itself as one of the most reliable and practical synthetic tools for the efficient construction of carbon-carbon/heteroatom (p-block elements other than carbon) bonds in both racemic and enantioselective manners. In contrast, development of the corresponding heteroatom-heteroatom cross-couplings has so far remained elusive, probably due to the under-investigated and often challenging heteroatom-heteroatom reductive elimination. Here we demonstrate the use of single-electron reductive elimination as a strategy for developing enantioselective S-O coupling under Cu catalysis, based on both experimental and theoretical results. The reaction manifests its synthetic potential by the ready preparation of challenging chiral alcohols featuring congested stereocentres, the expedient valorization of the biomass-derived feedstock glycerol, and the remarkable catalytic 4,6-desymmetrization of inositol. These results demonstrate the potential of enantioselective radical heteroatomic cross-coupling as a general chiral heteroatom-heteroatom formation strategy.
Catecholamine toxicity in cerebral cortex in dissociated cell culture (1988)

Identification of endogenous toxins and characterization of the mechanisms by which toxins produce cell injury and death may help understand both normal modeling of cell populations and connections in the CNS as well as abnormal cell loss. The toxicity of catecholamines intrinsic to the CNS was investigated using the model system of rat cerebral cortex in dissociated cell culture. All catecholamines tested, including norepinephrine (NE), dopamine, and epinephrine, were toxic to neurons as well as glia at a concentration of 25 microM when added to cultures 24 hr after plating. Toxicity was evident after 48 hr exposure to NE, as monitored by loss of cells from the cultures. Toxicity did not seem to be mediated by adrenergic receptors because, although the beta-adrenergic agonist isoproterenol (but not the alpha-adrenergic agonist phenylephrine) was similar in its toxic effect to NE, the beta-adrenergic antagonist atenolol did not block the toxic effect of NE. Toxicity could be mimicked by hydrogen peroxide, a product of the oxidative degradation of catecholamines. Toxicity of NE was blocked by catalase. The neurotoxin 6-hydroxydopamine (6-OHDA), supposedly selective for catecholaminergic neurons, was found to be toxic over the same concentration range as NE. These results suggest that endogenous catecholamines may play a role in normal and abnormal cell death, and suggest that caution be used in relying on the specificity of 6-OHDA and other supposedly selective neurotoxins.
Speech Recognition System in Car Noise Environment (2009)

The automotive ECU(Electronic Control Unit) becomes more complicated and is demanding many functions. For example, many automobile companies are developing driver convenience systems such as power window switch, LCM(Light Control Module), mirror control system, seat memory. In addition, many researches and developments for DIS(Driver Information System) are in progress. It is dangerous to operate such systems in driving. In this paper, we implement the speech recognition system which controls the car convenience system using speech, and apply the preprocessing filter to improve the speech recognition rate in car noise environment. As a result, we get the good speech recognition rate in car noise environment.
Reservoir Computing Using Laser Networks (2019)

Reservoir computing is a neuromorphic computing scheme inspired by the human brain. It has found great success as a versatile hardware-compatible application of machine learning concepts. In this paper, we highlight the fundamental working principles and important characteristics of reservoir computing with a particular focus on photonic systems and networks. These systems can further be enhanced by the inclusion of delayed variables to produce complex spatiotemporally mixed “time-multiplexed” networks. We use a simple nonlinear oscillator model, that is not only applicable to lasers, but can also describe a variety of other oscillating systems.
Change your Perspective : Exploration of a 3D Network created with Open Data in an Immersive Virtual Reality Environment using a Head-mounted Display and Vision-based Motion Controls (2015)

Year after year, technologies are evolving in an incredible rapid pace, becoming faster, more complex, more accurate and more immersive. Looking back just a decade, especially interaction technologies have made a major leap. Just two years ago in 2013, after being researched for quite some time, the hype around virtual reality (VR) arouse renewed enthusiasm, finally reaching mainstream attention as the so called head-mounted displays (HMD), devices worn on the head to grant a visual peek into the virtual world, gain more and more acceptance with the end-user. Currently, humans interact with computers in a very counter-intuitive two dimensional way. The ability to experience digital content in the humans most natural manner, by simply looking around and perceiving information from their surroundings, has the potential to be a major game changer in how we perceive and eventually interact with digital information. However, this confronts designers and developers with new challenges of how to apply these exciting technologies, supporting interaction mechanisms to naturally explore digital information in the virtual world, ultimately overcoming real world boundaries. Within the virtual world, the only limit is our imagination. This thesis investigates an approach of how to naturally interact and explore information based on open data within an immersive virtual reality environment using a head-mounted display and vision-based motion controls. For this purpose, an immersive VR application visualizing information as a network of European capital cities has been implemented, offering interaction through gesture input. The application lays a major focus on the exploration of the generated network and the consumption of the displayed information. While the conducted user interaction study with eleven participants investigated their acceptance of the developed prototype, estimating their workload and examining their explorative behaviour, the additional dialog with five experts in the form of explorative discussions provided further feedback towards the prototype’s design and concept. The results indicate the participants’ enthusiasm and excitement towards the novelty and intuitiveness of exploring information in a less traditional way than before, while challenging them with the applied interface and interaction design in a positive manner. The design and concept were also accepted through the experts, valuing the idea and implementation. They provided constructive feedback towards the visualization of the information as well as emphasising and encouraging to be even bolder, making more usage of the available 3D environment. Finally, the thesis discusses these findings and proposes recommendations for future work.
Treatment of anterior cross-bites in the early mixed dentition. (1992)

The diagnosis and treatment of anterior cross-bites are described by categorizing anterior cross-bites into three groups. Appropriate appliance therapy is described in sufficient detail to enable the general dental practitioner to provide interventional treatment.
SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates (2021)

The new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.
Effects of SO/sub 2/ shielding gas additions on GTA weld shape (1985)

Substantial increases in GTA weld depth/width ratio resulted from small additions of sulfur dioxide (SO/sub 2/) to the torch shielding gas when welding two stainless steels. The improvement was demonstrated on both Types 304 and 21-6-9 austenitic stainless steels, but would be expected for iron-base alloys generally. The weld pool shape achieved was essentially independent of variations in both SO/sub 2/ content of the torch gas and base metal composition when SO/sub 2/ in the shielding gas was in the range of 500 to 1400 ppm. With 700 ppm SO/sub 2/ in the torch gas, less than 30 ppm sulfur was added to an autogenous weld bead. For alloys where this additional sulfur can be tolerated and appropriate measures can be taken to handle the toxic SO/sub 2/, this technique offers a promising way to improve GTA weld joint penetration while suppressing variable penetration.
Repair of enamel by using hydroxyapatite nanoparticles as the building blocks (2008)

The application of calcium phosphates and their nanoparticles have been received great attention. However, hydroxyapatite (HAP) is not suggested in dental therapy to repair the damaged enamel directly although this compound has a similar chemical composition to enamel. We note that the size-effects of HAP are not taken into account in the previous studies as these artificial particles frequently have sizes of hundreds of nanometres. It has recently been revealed that the basic building blocks of enamel are 20–40 nm HAP nanoparticles. We suggest that the repair effect of HAP can be greatly improved if its dimensions can be reduced to the scale of the natural building blocks. Compared with conventional HAP and nano amorphous calcium phosphate (ACP), our in vitro experimental results demonstrate the advantages of 20 nm HAP in enamel repairs. The results of scanning electron microscopy, confocal laser scanning microscopy, quantitative measurement of the adsorption, dissolution kinetics, and nanoindentation, show the strong affinity, excellent biocompatibility, mechanical improvement, and the enhancement of erosion-free by using 20 nm particles as the repairing agent. However, these excellent in vitro repair effects cannot be observed when conventional HAP and ACP are applied. Clearly, nano HAP with a size of 20 nm shares similar characteristics to the natural building blocks of enamel so that it may be used as an effective repair material and anticaries agent. Our current study highlights the analogues of nano building blocks of biominerals during biomedical applications, which provide a novel pathway for biomimetic repair.
Modelling the management channel traffic of a synchronous digital hierarchy (SDH) network (2002)

In this paper, an analysis of the traffic load presented to the Synchronous Digital Hierarchy (SDH) management channel is described. Through a study of operational SDH networks, the traffic patterns on the management channel have been found to conform generally to a number of generic profiles. Computer simulation models of SDH network elements and their associated manager have been developed and used to characterize the behaviour of the management network. The paper also describes the simulation results for the performance of the management network when the traffic network is operating under normal and alarm conditions, for a ring topology of different network sizes.
The multiple-choice multi-period knapsack problem (2004)

This paper introduces the multiple-choice multi-period knapsack problem in the interface of multiple-choice programming and knapsack problems. We first examine the properties of the multiple-choice multi-period knapsack problem. A heuristic approach incorporating both primal and dual gradient methods is then developed to obtain a strong lower bound. Two branch-and-bound procedures for special-ordered-sets type 1 variables that incorporate, respectively, a special algorithm and the multiple-choice programming technique are developed to locate the optimal solution using the above lower bound as the initial solution. A computer program written in IBM's APL2 is developed to assess the quality of this lower bound and to evaluate the performance of these two branch-and-bound procedures.