gebhart/patrepeval huggingface dataset:
The Synthesis and Characterization of a Self-Assembling Amphiphilic Fullerene (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis and Characterization of a Self-Assembling Amphiphilic FullereneCraig J. Hawker, Paul M. Saville, and John W. WhiteCite this: J. Org. Chem. 1994, 59, 12, 3503–3505Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/jo00091a051https://doi.org/10.1021/jo00091a051research-articleACS PublicationsRequest reuse permissionsArticle Views561Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
1557. Acyclovir-Resistant (ACV-R) Herpes Simplex Virus (HSV) Disease in Patients with Hematologic Malignancies (HM) and Hematopoietic-Cell Transplant (HCT) Recipients (2018)

HSV reactivation is a challenging complication of HM and HCT. ACV prophylaxis effectively decreases the incidence of symptomatic HSV episodes, but may contribute to development of ACV-R HSV disease in this population. Outcomes in patients with ACV-R HSV disease remain poorly characterized. We identified adult HM patients and HCT recipients treated at Dana-Farber Cancer Institute who developed clinically significant ACV-R HSV disease between January 1, 2006 and March 1, 2018. HCT recipients typically receive 1 year of ACV prophylaxis after HCT, or longer in those with graft-vs. host disease. Clinical, microbiological and treatment details were collected. Nineteen patients had 27 episodes of ACV-R HSV disease during the study. Median age was 50 years (range 31–77); 15 (79%) were men. Fifteen (79%) were allogeneic HCT recipients and 4 (21%) had HM (3 CLL, 1 NHL). Thirteen (68%) had oral ulcers (HSV1), four (21%) had perineal ulcers (3 HSV2, 1 HSV1), one had HSV1 vesicles on the trunk and one had concurrent oral HSV1 and perineal HSV2 ulcers. Three patients had recurrent ACV-R HSV: two had one recurrence each and one had six recurrences. Of 19 first episodes of ACV-R HSV, 15 (79%) were confirmed by culture-based phenotypic resistance testing. Most episodes (20/27, 74%) were treated with foscarnet at clinical diagnosis or after failure of high-dose val-ACV; four of these episodes were also treated with topical cidofovir without success before foscarnet. Three episodes resolved on high-dose val-ACV or IV ACV alone and three were treated with cidofovir or brincidofovir initially. Coinfection was present in 19 episodes (70%), most often bacterial pneumonia or blood stream infection. Twenty-two episodes (81%) resolved completely after a median of 36 days (range 10–88) of treatment. No patient died of HSV disease but five (26%) died before resolution of ACV-R HSV, a median of 25 days (range 1–117) after treatment started. Eight patients died after ACV-R HSV resolved, a median of 111 days (range 27–382) after treatment started. Among HCT recipients, six (37%) died within 12 weeks of diagnosis. ACV-R HSV disease is an uncommon complication of HM and allogeneic HCT. While ACV-resistant HSV did not cause death in this cohort, death within 12 weeks of infection was common. N. C. Issa, GSK: Investigator, Research grant; Merck: Investigator, Research grant; Akros Pharma: Consultant, Consulting fee. F. M. Marty, Chimerix: Consultant and Investigator, Consulting fee and Research support. S. P. Hammond, Merck: Investigator, Research support.
Corpus cavernosum electromyography: technique and clinical implications. (1997)

Recently, corpus cavernosum EMG (CC-EMG) has been introduced into the diagnostic evaluation of erectile dysfunction. It has been demonstrated that CC-EMG may be a valuable tool in the evaluation of the integrity of the autonomic innervation of the corpus cavernosum. The interpretation and comparison of the recorded data still remains problematic due to a lack of standardization of recording procedures, technical equipment and of data analysis software. The assessment of recorded data was originally performed visually and nonquantitatively, however, more recently, computer-aided analysis of digitized measurements has proved to be more objective, less time-consuming and more reliable. Future efforts should be aimed at creating larger databases and differentiating between the various sources of lesions within the autonomic neural network of the corpus cavernosum.
Prediction of Remaining Life Time Based on Measurements of Stress for Thermal Barrier Coatings (2001)

Abstract Non-destructive determination of the remaining life of coatings of gas turbine parts is highly desirable. The present paper describes early attempts to prove the feasibility of doing this based on the optical measurement of the stress in the oxide that attaches the coating to the metal component. Both regression methods and neural network methods are compared and it was found that the neural network approach was superior for the case where multiple signal features were present. All methods provide useful predictions for the idealized case considered. Challenges presented by more complicated thermal cycles are discussed briefly.
Form measurements by optical and tactile scanning (2008)

The metrological concept and the optical probe system of the cylinder form coordinate measuring instrument (CMM) MFU110WP is described. Optical and tactile scanning form and position measurement data of a variety of standards and workpieces are discussed both in comparison to each other and to calibrated profiles of other measurement instruments. New scanning techniques like helical and spiral shaped scanning are presented.
Structural Enzymology of Aromatic Polyketide Synthase (2007)

The type II (aromatic) polyketide synthase biosynthesizes many important antibiotic and anticancer polyketides in bacteria and fungi. Similar to the type II fatty acid synthase, the aromatic PKS carries out a series of reactions catalyzed by individual soluble enzymes, each of which are encoded by a discrete gene. The growing polyketide intermediates are transported between the enzymes attached to the acyl carrier protein through a thioester linkage. Using X-ray crystallography and NMR, enzyme structures from the actinorhodin and tetracenomycin PKSs have been solved. The structure of the individual PKS enzymes reveal key molecular features that help explain the observed substrate specificity, enzyme mechanism and protein-protein interactions. These structures are also a valuable resource to guide combinatorial biosynthesis of polyketide natural products.
C-9 : Thermotropic Liquid Crystalline Polymer/Carbon Fiber Composite by Using In-situ Graft Polymerization (1991)

Thermotropic liquid crystal polymers are a new class of high performance engineering thermoplastics. The superior properties of these liquid crystal polymers might be linked in part to orientational self-ordering of their constituent semi-rigid chains. In addition, their excellent physical properties make them attractive candidates for matrix in advanced composites.
In order to synthesize thermotropic liquid crystalline polyester, pimelic acid, p-acetoxybenzoic acid and diacetoxyhydroquinone were used as monomers for this study. By using in-situ polymerization, liquid crystalline polyester was grafted on the surface of carbon fiber effectively.
For the creation of active sites onto the carbon fiber, plasma etching method was used and the modification of carbon fiber surface has been carried out as a function of plasma treatment time.
In the case of untreated carbon fiber, mechanical properties of liquid crystalline composite increase with increasing the volume fraction of carbon fiber. From the data of mechanical properties for liquid crystalline polymer composites, maximum values of flexural and tensile properties have been occurred at 7.5 min of plasma treatment time
SEM and optical microscopic analyses have also confirmed that mechanical properties of liquid crystalline composites have been improved with increasing plasma treatment time of carbon fiber surface.
518. The occurrence of dihydrokœmpferol in Nothofagus species (1960)

N. F. Janes and J. W. W. Morgan, J. Chem. Soc., 1960, 2560 DOI: 10.1039/JR9600002560
Polyimide Optical Waveguides Fabricated by Direct Electron Beam Writing (1995)

Polymer optical waveguides are attractive for fabricating economical and practical optoelectronic devices and interconnections in optical communication systems [1,2]. Channel waveguides, therefore, have been produced using several polymers such as poly(methyl methacrylate), polystylene, poly(organosiloxane), and polyimide [3-6]. One of the first priorities for polymer waveguides is high thermal stability so that soldering can be used in conventional device fabrication. Fluorinated polyimides are promising candidates for waveguide materials because they show high thermal stability and low optical loss near the IR wavelength region. We have previously developed novel fluorinated polyimides [7] and manufactured a single-mode optical waveguide for them by using conventional reactive ion etching (RIE) [8]. Moreover, we recently clarified that the refractive index of fluorinated polyimides can be controlled by electron beam irradiation [9], and that optical waveguides can thus be fabricated by direct electron beam writing (DEBW) [10,11]. This method is very useful because the fabrication process becomes simpler than when using RIE. In this paper, we propose a new optical waveguide fabricated by DEBW, which consists of a single material and a simple two-layer structure.
Using Topic Models to Support Software Maintenance (2012)

Our recent research has shown that the latent information found by commonly used topic models generally relates to the development history of a software system. While it is not always possible to associate these latent topics with human-oriented concepts, it is demonstrable that they identify historical maintenance relationships in source code. Specifically, when a developer makes a change to a software project, it is common for a significant part of that change to relate to a single latent topic. A significant conclusion can be drawn from this: latent topic models identify co-maintenance relationships with no supervision, and therefore topic models can be used to support the maintenance phase of software development.
Purification and properties of a periplasmic D-xylose-binding protein from Escherichia coli K-12. (1982)

Escherichia coli contains a cold osmotic shock-releasable binding protein for D-XylOSe which has been purified and characterized.The D-xylose-binding protein has an apparent molecular weight of 37,000 as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and amino acid analysis.D-Xylose-binding protein has an apparent absolute specificity for D-XY- lose and binds one molecule of D-XylOSe per molecule of protein with a Kd of 0.6 PM.The protein exhibits native tryptophan fluorescence (hex 284 nm, he, 345 nm) and a fluorescence enhancement (32%) associated with D-xylose binding which saturates with a Kd of 0.5 PM.D-Xylose-binding protein does not bind to a Cibacron blue 3FGA affinity column but does interact with a tetraiodofluorescein-agarose affinity column.D-XYlose-binding protein interaction with tetraiodofluorescein, if present, does not produce a red shift in the absorption spectrum of the dye in contrast to the L- arabinose-and D-galactose-binding proteins.Tryptophan oxidation with N-bromosuccinimide results in a concomitant drop in xylose binding.D-Xylose-binding protein contains no cysteine and possesses a PI of 7.4.In recent years, considerable evidence has bee? obtained implicating a transport and, in some cases, a chemotactic role for a group of periplasmic, osmotic shock-releasable proteins which are generally termed binding proteins (1, 2).These proteins are capable of specific, high affinity binding of certain metal ions, carbohydrates, amino acids, and other metabolites (2).Carbohydrate-binding proteins for L-arabinose (3-5), Dribose (6, 7), D-gahCtOSe (3, 4, 8, 9), and maltose (10) have been previously purified and characterized.D-Xylose transport in Escherichia coli has been reported previously (11-15), and it has been suggested that the genes coding for transport, xylose isomerase and xylulokinase, are probably regulated as an operon (11-14).L-Arabinose and D- ribose are transported via two transport systems, a "low affinity" and a "high affinity" transport system; in both cases, binding proteins have been found to be associated with the high affinity transport system (3, 7, 15, 16).Studies in this laboratory and others have indicated the presence of at least two xylose uptake systems with varying affinities (14, 15).Preliminary studies of xylose transport in E. coli K-12 have indicated the release of a periplasmic binding protein subsequent to osmotic shock and a reduction of the high affinity
Non-parametric regression for patch-based fluorescence microscopy image sequence denoising (2008)

We present a non-parametric regression method for denoising fluorescence video-microscopy volume sequences. The designed method aims at using the 3D+t information in order to restore acquired data contaminated by Poisson and Gaussian noise. We propose to use a variance stabilization transform to deal with the combination of Poisson and Gaussian noise. Consequently, we further propose an adaptive patch-based framework able to preserve space-time discontinuities and reduce significantly noise level using the 3D+t space-time context. This approach lead to an algorithm whose parameters are calibrated and then ready for intensive use. The performance of the proposed method are then demonstrated on both synthetic and real image sequences using quantitative as well as qualitative criteria.
The influence of nitrogen dioxide on the determination of hydrogen cyanide in mainstream and sidestream cigarette smoke and the improvement of the determination method by continuous flow analyzer (2014)

Hydrogen cyanide is a well-known toxic component in cigarette smoke. Accurate determination of hydrogen cyanide is of great significance to assess the risk of cigarettes to public health.
Cool glove leathers made using thermoresponsive sytans (2014)

Protection is the main function of gloves; also comfort of the wearer has to be kept in mind while making gloves without compromising on strength and flexibility. Body dissipates heat in the form of sweat; sweating through hands is likely to be more while using gloves in relatively hot weather conditions resulting in discomfort and slipperiness. In order to overcome these problems there is a need for development of materials, which can respond to temperature changes providing comfort and protection. In our current study, Phase Changing Material (PCM) was encapsulated into condensate polymers of melamine formaldehyde for preparation of thermoresponsive syntan. The syntan was characterised using different techniques such as Differential Scanning Calorimetry (DSC), Thermo Gravimetric Analysis (TGA) and Scanning Electron Microscopy (SEM). Glove leathers made using this syntan were termed “Cool glove leathers” as they showed thermoresponsive behaviour, which exhibited a temperature difference of 1.5±0.5 °C to that of control leather samples with 0.5±0.4 °C. The cool glove leathers were tested for various properties like strength, organoleptic and thermoresponsive function.
DEMO: autonomous science analysis, planning, and execution on the EO-1 mission (2003)

In 2003, the Earth-Orbiting One (E01) spacecraft will demonstrate several integrated autonomy software technologies to enable autonomous science. The Autonomous Sciencecraft Experiment (ASE) software will demonstrate the potential for future space missions to use onboard decision-making to detect science events and respond autonomously to capture short-lived science events and to downlink only the highest value science data. The ICAPS software demonstration will consist of a typical E01 scenario using this autonomy software.
INVOLVEMENT OF A CENTRAL α‐ADRENOCEPTOR SYSTEM IN ANTIDEPRESSANT POTENTIATION OF HYPERTHERMIA INDUCED BY THYROTROPIN RELEASING HORMONE (1980)

Thyrotropin releasing hormone (TRH) causes hyperthermia in mice which is potentiated by tricyclic antidepressants (nortriptyline, imipramine, clomipramine, amitriptyline), the monoamine oxidase inhibitor, tranylcypromine, and various other antidepressants (maprotiline, nomifensin, viloxazine). Only iprindole is ineffective. The effect of mianserin, itself hypothermic, could not be interpreted. A property shared by the potentiating substances seems to be activation of a central adrenoceptor system. The potentiation of TRH-induced hyperthermia which seems to be specific to antidepressants might be used in the selection of antidepressants.
Real-Time Demonstration of Optimized Spectrum Usage with LSA Carrier Aggregation (2016)

Abstract Mobile broadband networks will face a tremendous growth in data traffic demand over the next 20 years. A key requirement for the evolution of radio access networks is the increase in the amount of spectrum and optimized spectrum usage, in order to meet future service demands. More efficient spectrum use will come with evolving technology features and novel spectrum sharing models. Candidates for technology improvements are higher order and massive MIMO systems, cooperative base stations and CoMP techniques, highly optimized resource allocation algorithms, network densification with inter-cell interference management and highly flexible carrier aggregation techniques to extend spectrum. In this paper, we will highlight carrier aggregation combined with flexible spectrum assignment and use of spectrum databases following novel licensing schemes. We give an overview of LSA activities, present a 3CA demonstration platform enabling the LSA concept and discuss its implementation constraints.
A Survey Demonstrating Lack of Consensus on the Sequence of Medications for Treatment of Hyperkalemia Among Pediatric Critical Care Providers* (2015)

This survey revealed notable variability in the choice and sequence of medications for treatment of life-threatening hyperkalemia with surprisingly few participants in compliance with the advanced cardiovascular life support hyperkalemia guidelines. A standardized approach for pediatric life-threatening hyperkalemia is recommended to improve resuscitation quality.
Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine (2002)

Tirapazamine (TPZ, 1,2,4-benzotriazin-3-amine 1,4-dioxide) is a bioreductive hypoxic cytotoxin currently in Phase II/III clinical trials in combination with radiotherapy and with cisplatin-based chemotherapy. As part of a program to develop TPZ analogues with improved solubility/potency and therapeutic indices, we synthesized 34 1,2,4-benzotriazin-3-amine 1,4-dioxides (BTO) to examine structure-activity relationships (SAR) for ring substitution. The electronic, hydrophobic, and steric parameters of substituents at the 5-, 6-, 7-, and 8-positions were systematically varied, and the aqueous solubility and one-electron reduction potentials [E(1)] of the analogues were determined. For each compound, we determined cell killing of mouse SCCVII tumor cells in vitro under aerobic and hypoxic conditions by clonogenic survival and determined their relative hypoxic toxicity (RHT; relative to TPZ) and hypoxic cytotoxicity ratio (HCR). A subset of compounds was independently evaluated using a 96-well SRB proliferation assay, the data from which correlated well with that derived by the clonogenic endpoint. Most substituents, except 5- and 8-dimethylamino and 8-diethylamino, gave analogues less soluble than TPZ. E(1) values ranged from -240 mV through -670 mV (with TPZ having a value of -456 mV) and correlated well with the electronic parameter sigma for substituents at the 5-, 6-, 7-, and 8-positions. Aerobic cytotoxic potency showed a strong positive correlation with E(1) (i.e., electron-withdrawing substituents increased aerobic toxicity). Hypoxic cytotoxicity also generally increased with increasing E(1), with a maximum (RHT up to 3.9-fold) seen in halo- and trifluoromethyl-substituted BTO derivatives having E(1) between ca. -370 to -400 mV. Analogues with high HCRs (>50) all had E(1)s in the range -450 to -510 mV (weakly electron-donating substituents) with the exception of the 8-CF(3) analogue, which had an HCR of 112 against SCCVII despite a high E(1) of -372 mV). The results suggest that ring-A substituents in BTO analogues can be used to predictably vary one-electron reduction potentials and also provide a much better definition than previously of the optimum range of these reduction potentials for a desirable biological activity profile (high HCR, RHT, and solubility).
Hot-spot prediction and alleviation in distributed stream processing applications (2008)

Many emerging distributed applications require the real-time processing of large amounts of data that are being updated continuously. Distributed stream processing systems offer a scalable and efficient means of in-network processing of such data streams. However, the large scale and the distributed nature of such systems, as well as the fluctuation of their load render it difficult to ensure that distributed stream processing applications meet their Quality of Service demands. We describe a decentralized framework for proactively predicting and alleviating hot-spots in distributed stream processing applications in real-time. We base our hot-spot prediction techniques on statistical forecasting methods, while for hot-spot alleviation we employ a non-disruptive component migration protocol. The experimental evaluation of our techniques, implemented in our Synergy distributed stream processing middleware over PlanetLab, using a real stream processing application operating on real streaming data, demonstrates high prediction accuracy and substantial performance benefits.
Planck 2015 results. XII. Full Focal Plane simulations (2015)

We present the 8th Full Focal Plane simulation set (FFP8), deployed in support of the Planck 2015 results. FFP8 consists of 10 fiducial mission realizations reduced to 18144 maps, together with the most massive suite of Monte Carlo realizations of instrument noise and CMB ever generated, comprising $10^4$ mission realizations reduced to about $10^6$ maps. The resulting maps incorporate the dominant instrumental, scanning, and data analysis effects; remaining subdominant effects will be included in future updates. Generated at a cost of some 25 million CPU-hours spread across multiple high-performance-computing (HPC) platforms, FFP8 is used for the validation and verification of analysis algorithms, as well as their implementations, and for removing biases from and quantifying uncertainties in the results of analyses of the real data.
Cerebrospinal Fluid Markers in Dementia With Lewy Bodies Compared With Alzheimer Disease (2003)

The tau levels in CSF may contribute to the clinical distinction between AD and DLB. Beta-amyloid CSF levels are similar in both dementia disorders and reflect disease progression better than tau levels. Interleukin CSF concentrations do not distinguish between AD and DLB.
Isomerazation (2002)

The prelims comprise: Introduction Racernizations and Epirnerizations Isomerizations Conclusion