gebhart/patrepeval huggingface dataset:
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil (2011)

The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.
Sleeping difficulties and health-related quality of life in Parkinson's disease (2016)

The sleep difficulties in PD are frequent. The long sleeping patients have depression, stress, and fatigue.
Maintaining object-oriented software (1993)

The maintenance requirements of object-oriented software, including the ability to make changes easily and an in-depth understanding of the software's structure and behavior, are discussed. The problems encountered by a maintainer trying to understand object-oriented software by reading and statically analyzing it are described. The problems caused by dynamic binding, polymorphism, and cooperating object classes in object-oriented software maintenance are reviewed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Comparing Interpretive Methods Targeting Invasive Species Management at Cumberland Island National Seashore (2012)

Interpretation designed to increase public understanding and appreciation of environmental issues can provide support for management actions in protected areas, but the relative impact of different interpretive strategies on public awareness and attitudes has not been adequately explored. The purpose of this research was to compare the effects of two interpretive programs (a non-personal, visual-based flyer and an interpersonal, audio-based talk) relative to a control group on visitors’ knowledge of, attitudes toward, and support for invasive species management at Cumberland Island National Seashore, Georgia. In general, the interpretive talk appeared to be more effective than the flyer at increasing awareness and generating support for invasive species management. Although visitors exposed to each of the treatments displayed greater knowledge of invasive species, effects on attitudes and management preferences were minimal. Future research examining the effects of interpretive media on public awareness of and support for controversial management decisions could therefore explore mechanisms for maximizing the impact of interpretive programming on visitors’ attitudes and preferences.
A neural network approach to Doppler-based target classification (1992)

This paper describes a target classification system which uses the measured Doppler signatures to excite a neural network. The radar target is assigned to one of four possible classes: airplanes and ground vehicles, helicopters, groups of small moving targets (e.g. persons), and clutter. A larger number of classes would result in poorer performance of the system, provided that the only available sources of information are the phase and amplitude of the radar signal.
Red Blood Cells and Their Deformability (1981)

In the previous chapter we studied the flow properties of blood. In this chapter we turn our attention to the red blood cells. Red blood cells are the gas exchange units of animals. They deliver oxygen to the tissues of all organs, exchange with CO2, and return to the lung to unload CO2 and soak up O2 again. This is, of course, what circulation is all about. The heart is the pump, the blood vessels are the conduits, and the capillary blood vessels are the sites where gas exchange between blood and tissue or atmosphere takes place.
2.45GHz-band Reader Antenna Based on High-Impedance Surface (2010)

2.45GHz band is one of the frequency bands which are commonly used in RFID. In order to achieve an antenna with good performance in this band, based on improving the aperture-coupled-feed antenna structure, we introduce a high-impedance surface of microwave photonic crystal structure in antenna design. By novel structure and effective design idea, the antenna can maintain a high gain and has a better stability in a wider band. The size of the antenna will be reduced at the same time, so that the overall performance of the antenna will be more perfect. The experiment results show that the 2.45GHz-band reader antenna based on high-impedance surface proposed in this paper has good performance, and the novel structure and effective design ideas of the antenna have practical significance for the reader antenna design.
Safety of Iron Sucrose in Hemodialysis Patients Intolerant to Other Parenteral Iron Products (2004)

Iron sucrose therapy is safe and well tolerated in hemodialysis patients intolerant to iron dextran and/or sodium ferric gluconate.
Addressing requirements for chiral smectic liquid crystal active backplane spatial light modulators (1993)

Abstract An account is given of the charge effects associated with chiral smectic liquid crystal switching. It is noted that below a certain Ps ‘fast’ scan switching, i.e. switching where the addressing time is less than the liquid crystal response time, is possible for binary switching. However at higher values of Ps the liquid crystal must be addressed at approximately its optical response time. For analogue switching the ‘fast’ scan option is not generally useful. Addressing schemes designed to maintain overall charge balance for binary switching are described. In most cases these schemes require an inverse frame or a blanking pulse to achieve this. For some applications the loss of validity of the image thus produced renders these schemes unsuitable and schemes to overcome this are presented. They rely on bistable switched states. A brief account is given of possible schemes for analogue switching.
microRNA-128a dysregulation in transgenic Huntington’s disease monkeys (2014)

Our studies found that miR-128a may play a critical role in HD and could be a viable candidate as a therapeutic or biomarker of the disease.
A 600V HVIC process with a built-in EPROM which enables new concept gate driving (2004)

A junction isolation type 600 V HVIC process, which can produce EPROM memory devices, is developed for the first time. In this process, the 0.8 /spl mu/m CMOS design rule is applied and it is 20% finer than previous work. A new concept gate driver can be realized with a digital trimming circuit, in which dead-time control is possible. The trial fabrication devices exhibit compatible characteristics for the 0.8 /spl mu/m CMOS and EPROM. The modified-MFFP (multiple floating field plate) structure with GSR (ground-coupled shield ring) is applied to 600 V Nch/PchMOSs for level shift circuits, and as a result of reduction of the influence of the electric field from the level shift wiring, each device exhibits a high breakdown voltage beyond 700 V.
Least-Squares Frequency-Acquisition Algorithm (1988)

Algorithm finds frequency and phase of sinudoidal signal in presence of noise. Algorithm is special case of more-general, adaptive-paramenter-estimation techniques. Computational requirements of algorithm comparable to corresponding fast-Fourier-transform (FFT) algorithm. Algorithm works directly in time domain, whereas FFT algorithm transforms data into frequency domain for estimation and detection and requires secondary algorithm to interpolate between frequencies.
Detailed mapping in the southern part of the Ilímaussaq intrusion (Kangerdluarssuk fjord) (1971)

Detailed mapping at a scale of 1:10 000 of an area around the head of the Kangerdluarssuk fjord in the southern half of the Ilimaussaq intrusion was made. The purpose of this was to map accurately the relations of naujaite inclusions in the lujavrites. During the work it became clear that a detailed study of the transitions between the lujavrites and kakortokites was of much greater importance. The reader is referred to Ferguson (1970, p. 338) for a summary of the previous ideas about the origin of the lujavrites.
The safety and efficacy of terazosin for the treatment of benign prostatic hyperplasia. (1989)

The efficacy and safety of terazosin was evaluated in 28 normotensive patients with symptomatic benign prostatic hyperplasia (BPH) ranging in age between 52-72 years. The parameters utilized to assess the efficacy of terazosin included peak and mean urinary flow rate, micturition symptom score and the patients' global assessment of symptomatic improvement. The dose of terazosin was titrated to 5 mg/day over a one-month interval, provided significant adverse drug reactions were not observed. Twenty-two (79%) of the 28 patients completed the terazosin dose-titration study, 5 (18%) were withdrawn owing to adverse drug reactions and 1 (3%) was withdrawn owing to poor compliance. Overall, the mean systolic blood pressure, increased 3 mmHg (3%) and the diastolic blood pressure decreased 1 mmHg (1%). The peak and mean urinary flow rates increased 63% and 61%, respectively. The obstructive and irritative symptom scores decreased 62% and 33%, respectively. The improvements in urinary flow rates and symptom scores were clinically and statistically significant. Overall, 61% of the patients indicated that their voiding symptoms were markedly improved on terazosin and 64% of the participants have elected to voluntarily continue on terazosin indefinitely. In conclusion, terazosin represents a safe and effective treatment for symptomatic BPH.
Thermal Elasto-Viscoplastic Damage Behavior of Structural Members in Hot-Dip Galvanization (2002)

Continuum damage mechanics is applied to the prediction of the initiation of cracks on structural members in hot-dip galvanization. The elastoviscoplastic constitutive equation considering damage, in which most material parameters are temperature-dependent, is employed in the three-dimensional finite element analysis of the structural behavior in hot-dip galvanization. The material constants concerning damage are determined by the comparison of the finite element solutions with the bending test results for the stiffened plates in molten zinc in order to consider the effect of zinc-embrittlement of the material. Numerical study is conducted for the possibility of cracking near the holes for bolts on pylon members in hot-dip galvanization.
Polarization-transforming antenna feed horns (1971)

A set of polarization-transforming antenna feed horns has been developed for an <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">X</tex> -band radar antenna. Use of the proper feed horn permits transmission of horizontal, vertical, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">45\deg</tex> linear, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">135\deg</tex> linear, right circular or left circular polarization, and reception of both the parallel- (same sense as transmitted) and orthogonal-polarized return.
Properties of Portland cement concretes containing pozzolanic admixtures (1981)

A laboratory comparison was made of the properties of a concrete containing no pozzolan with several mixtures containing pozzolans. Used were a natural pozzolan (Lassenite), two fly ashes of different fineness and low carbon and an amorphous silica fume dust from a metal-producing plant. The no-pozzolan mixture had a cement factor of 564 lbs per cubic yard (338 kg/cu m), a water to cement-weight ratio of 0.53, a slump of 3 inches (76mm), 6 percent air and a compressive strength of approximately 4500 psi (31 MPa) at 28 days. One cement, one coarse crushed limestone aggregate, and one fine river aggregate were used. The basic mixture was modified in three schemes: a 15 percent equal volume replacement of pozzolan for cement, a 25 percent similar replacement, and a 2 for 1 replacement of pozzolan for cement, whereby 13 volume percent was replaced by 26 percent pozzolan with the extra volume compensated for by removing fine aggregate. The concretes were compared for the amount of air entraining agent, compressive and tensile splitting strengths, modulus of elasticity, drying shrinkage, skid resistance, abrasion resistance, scaling resistance, freeze-thaw durability, chloride permeability, and outdoor exposure. Evaluations were done at equal ages and at approximately equal strengths. Replacing a faster reacting binder with a slower one, produced lower early strengths and adversely affected the properties which are highly dependent on strength. The measures of durability were greatly affected by the air contents and aging or treatment prior to exposure. The amorphous silica fume dust increased the early strengths of a fly ash mixture. (FHWA)
[Gemcitabine and ionizing radiations: radiosensitization or radio-chemotherapy combination]. (2002)

Gemcitabine is a pyrimidine analog which has demonstrated antitumoral activity in a variety of solid tumors including bladder, non-small cell lung and pancreatic cancers. Gemcitabine is a potent radiosensitizer of human tumor cells. This review summarizes preclinical studies designed to elucidate the mechanism of action of gemcitabine with ionizing radiation. Phase I-II ongoing trials of combination of radiation therapy and gemcitabine are trying to determine the optimal dose and schedule which could be used in daily clinical activity. The mechanism of radiosensitization is thought to be simultaneously gemcitabine-induced dATP (deoxyadenosine triphosphate) depletion and cell cycle redistribution into the S phase. Although there are no real study which has proven supra-additive combination, the recent acute side effects in several clinical studies oblige physicists to determine with precision the maximum tolerated dose of gemcitabine in association with ionizing radiation. Radiosensitization conditions can be obtained either with a long exposition to a low concentration or a short exposition to a high concentration. Radiation sensitivity begin to be detected four hours after treatment for 48 hours. A dose about 100 mg/m2/week of gemcitabine could be used with radiation therapy according to recent phase I results. This limiting dose is approaching to a radiosensitization context where the effect of one agent is increased by another agent which is inactive or poorly active for the effect under consideration. In this type of regimen, the two modalities do interact with a frequent inhibition of recovery from potentially lethal damage and a probably increase of late side effects of radiation therapy. In contrast, radio-chemotherapy combination is used for a therapeutic advantage when the drug by itself is active against the tumor but does not enhance late side effects of radiation on the critical normal tissues within the irradiated volume. Gemcitabine surely is a strong radiosensitizer even at low doses with future extended combined modality therapeutic indications. The ultimate goal of combined treatments should be an increased therapeutic ratio.
Using the Internet for Surveys and Health Research (2002)

This paper concerns the use of the Internet in the research process, from identifying research issues through qualitative research, through using the Web for surveys and clinical trials, to pre-publishing and publishing research results. Material published on the Internet may be a valuable resource for researchers desiring to understand people and the social and cultural contexts within which they live outside of experimental settings, with due emphasis on the interpretations, experiences, and views of 'real world' people. Reviews of information posted by consumers on the Internet may help to identify health beliefs, common topics, motives, information, and emotional needs of patients, and point to areas where research is needed. The Internet can further be used for survey research. Internet-based surveys may be conducted by means of interactive interviews or by questionnaires designed for self-completion. Electronic one-to-one interviews can be conducted via e-mail or using chat rooms. Questionnaires can be administered by e-mail (e.g. using mailing lists), by posting to newsgroups, and on the Web using fill-in forms. In "open" web-based surveys, selection bias occurs due to the non-representative nature of the Internet population, and (more importantly) through self-selection of participants, i.e. the non-representative nature of respondents, also called the 'volunteer effect'. A synopsis of important techniques and tips for implementing Web-based surveys is given. Ethical issues involved in any type of online research are discussed. Internet addresses for finding methods and protocols are provided. The Web is also being used to assist in the identification and conduction of clinical trials. For example, the web can be used by researchers doing a systematic review who are looking for unpublished trials. Finally, the web is used for two distinct types of electronic publication. Type 1 publication is unrefereed publication of protocols or work in progress (a 'post-publication' peer review process may take place), whereas Type 2 publication is peer-reviewed and will ordinarily take place in online journals.
Platelet-neutrophil interactions. Possible relevance in the pathogenesis of thrombosis and inflammation. (1992)

Evidence indicates that complex interactions occur between platelets and neutrophils. Mediators released by activated platelets may act as stimuli for neutrophils, but platelets may also limit neutrophil activation. Similarly, neutrophils, depending upon their degree of activation, may bring about both enhancement and inhibition of platelet responses. The elaborate cross-talk among platelets and neutrophils, cells involved in hemostatic and phlogistic reactions, may condition the development and the course of thrombotic and inflammatory diseases; therefore, modulation of platelet-neutrophil interactions may represent a therapeutic target in these conditions. In this review, the mediators involved in the platelet-dependent modulation of neutrophil activation and, conversely, the mechanisms whereby neutrophils modify platelet responses are described. Moreover, the possible relevance of these interactions in the pathogenesis of thrombosis and inflammation is discussed.
Smooth transition exponential smoothing (2004)

Abstract Adaptive exponential smoothing methods allow a smoothing parameter to change over time, in order to adapt to changes in the characteristics of the time series. However, these methods have tended to produce unstable forecasts and have performed poorly in empirical studies. This paper presents a new adaptive method, which enables a smoothing parameter to be modelled as a logistic function of a user‐specified variable. The approach is analogous to that used to model the time‐varying parameter in smooth transition models. Using simulated data, we show that the new approach has the potential to outperform existing adaptive methods and constant parameter methods when the estimation and evaluation samples both contain a level shift or both contain an outlier. An empirical study, using the monthly time series from the M3‐Competition, gave encouraging results for the new approach. Copyright © 2004 John Wiley & Sons, Ltd.
Ein neuer Motortrepan für die Keratoplastik (1972)

ZusammenfassungSchon sehr früh, ehe die übrigen, mit der Keratoplastik zusammenhängenden klinischen Probleme gelöst waren, wurde versucht, den Hornhauttrepan weiter zu entwickeln.
An innovative fully automated RTM plant for class ``A`` mass transit applications (1996)

In order to guarantee high quality and reliability of molded parts, a fully automated RTM plant, equipped with a smart system, was set up. The controls and the servo-mechanisms make the plant require a very low labor, so it represents a true innovative industrial solution. The plant configuration was optimized to maximize the investment return also on low and medium production series. The plant and the smart system are well described. The smart system is formed of four main blocks: (1) A mathematical model that simulates the rheology and the kinetic of the injected resin system; (2) sensor for temperature, pressure and degree of polymerization and a data acquisition system; (3) software for comparison, in the real time, between mathematical model data and experimental ones; (4) servo-mechanisms interfacing software-plant. The smart system permits: complete filling of the mold even if the molding parameters were selected out of the admitted working values range; optimization of the molding time by means of sensors based on evaluation of the electric conductivity of the resin system, as function of degree of polymerization. A comparative cost analysis for class A bus body panels was executed with the respect to different production technologies. The comparison showsmore » the economical advantages of the adopted choice.« less
X-Ray Diffraction Studies on Protein Fibers. I. The Large Fiber-Axis Period of Collagen (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-Ray Diffraction Studies on Protein Fibers. I. The Large Fiber-Axis Period of CollagenRichard S. BearCite this: J. Am. Chem. Soc. 1944, 66, 8, 1297–1305Publication Date (Print):August 1, 1944Publication History Published online1 May 2002Published inissue 1 August 1944https://pubs.acs.org/doi/10.1021/ja01236a027https://doi.org/10.1021/ja01236a027research-articleACS PublicationsRequest reuse permissionsArticle Views409Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts