gebhart/patrepeval huggingface dataset:
Identification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16 (1996)

The herpes simplex virus transactivator VP16 and the virion host shutoff protein vhs are viral structural components that direct the activation of immediate-early gene expression and the arrest of host protein synthesis, respectively, during an infection. Recent studies show that VP16 and vhs physically interact with each other in vitro and in infected cells, suggesting that their respective regulatory functions are coupled. In this report, we used the yeast two-hybrid system and affinity chromatography with purified VP16 fusion proteins to precisely map a region in vhs that directs interaction with VP16. Deletion analysis of vhs demonstrated that a 21-amino-acid-long domain spanning residues 310 to 330 (PAAGGTEMRVSWTEILTQQIA) was sufficient for directing complex formation with VP16 in vivo and in vitro when fused to a heterologous protein. Site-directed mutagenesis of this region identified tryptophan 321 as a crucial determinant for interaction with VP16 in vitro and in vivo and additional residues that are important for stable complex formation in vitro. These findings indicate that vhs residues 310 to 330 constitute an independent and modular binding interface that is recognized by VP16.
Benzoyl peroxide gel in acne therapy. (1976)

A micronized benzoyl peroxide, in a magnesium aluminum silicate-alcohol gel, appears to achieve dramatic objective improvement of the comedo and papular stages of acne, as well as associated seborrhea. Burning sensations and excessive erythema, found with similar modalities, have been virtually eliminated.
Histoire et système de communication au Moyen Age (1997)

Les historiographes, au-delà de la simple nomenclature des sources disponibles, ont su déceler dans le corpus des textes historiques un véritable trésor, qui nous transmet intactes les représentations que les hommes du Moyen Age se faisaient de leur propre passé, de leur identité, de leur système de valeurs, en même temps qu'une gamme étendue de modes d'expressions et de techniques de travail intellectuel. Interrogés à la lumière des acquis de l'histoire des mentalités, ces textes se sont rév...
School-Based Decision Making and the Empowerment of Secondary School Teachers (1998)

The purpose of this study was to investigate teacher empowerment in high schools that had a school council over varying lengths of time (either zero, one, two, or three years). Teachers in this study were in a state that mandated a school governance process to involve teachers in the decision-making process. A School Participant Empowerment Scale (SPES) was used to measure empowerment and it contained the following six subscales: decision making, autonomy, self-efficacy, professional growth, status, and impact. Each teacher received a packet containing a demographic form, the School Participant Empowerment Scale (six scales), and a self-addressed, stamped envelope. The returned data were analyzed by a MANOVA technique resulting in a significant Wilkeslambda. A follow-up procedure (ANOVA) indicated that a significant difference existed on the decision-making scale between schools with no experience with councils and those with three years experience. There were no significant differences for the remaining subscales. These results are interpreted and implications for practitioners and policymakers are suggested.
Building With Bricks and Mortar: The Revenue Impact of Opening Physical Stores in a Multichannel Environment (2015)

A crucial decision firms face today is which channels they should make available to customers for transactions. We assess the revenue impact of adding bricks-and-mortar stores to a firm's already existing repertoire of catalog and Internet channels. We decompose the revenue impact into customer acquisition, frequency of orders, returns, and exchanges, and size of orders, returns, and exchanges. We use a multivariate baseline method to assess the impact of adding the physical store channel on these revenue components. As hypothesized, store introduction cannibalizes catalog sales and has much less impact on Internet sales. Also as hypothesized, returns and exchanges increase. Interestingly, transaction sizes of purchases, returns, and exchanges do not change. The “availability effect” produces a net increase in purchase frequency across channels. This more than compensates for increased returns, producing a net increase in revenues of 20% by adding the store channel. Our findings yield a deeper understanding of the revenue relation between channels, and of the dynamic cross-channel effects of marketing actions.
A Dense Gate Matrix Layout Method for MOS VLSI (1980)

A rapid and systematic method for performing chip layout of VLSI circuits is described. This method utilizes the configuration of a matrix composed of interacting rows and columns to provide transistor placement and interconnections. This structure, which is orderly and regular, gives high device-packing density and allows ease of checking for layout errors. Resulting layouts may be updated to new design rules automatically. This method has been used in the layout of a 20 000-transistor section of a VLSI circuit.
Optical Multiplexing in Television Film Equipment (1956)

The primary reason for multiplexing TV film cameras and TV film projectors is economy of equipment and/or space. A further reason can be the insurance of stand-by protection, at nominal cost, when continuity of programming assumes high importance. The optical multiplexer described here satisfies both requirements when integrated into a TV film pickup system. Design parameters and operation are discussed.
On the synthesis and complexity of feedforward networks (2002)

A method for synthesis of one hidden layer feedforward neural networks approximating functions of several variables to the desired degree of accuracy is presented. The method fully determines the network architecture including the values of all weights. In the first step, the inverse Radon transform is used to decompose a problem of of approximating a function of several variables into several problems of approximating a function of one variable. In the second step, each of the obtained one-dimensional functions is approximated by a sub-network. Then sub-networks are combined to construct the network approximating the original function. The upper bound of the final approximation error /spl epsi/ and errors at each step are estimated. The complexity of the network, or the number of neurons in the hidden layer, is O/sub /spl epsi//(1//spl epsi//sup n/), where n is the dimension of the space.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Space-Charge Distortion in the Brookhaven Ionization Profile Monitor (1987)

An Ionization Profile Monitor (IPM) has been in use at the Brookhaven Alternating Gradient Synchrotron for several years to measure the horizontal and vertical profiles of the circulating beam. The device, which collects ions from the interaction of the beam with residual gas molecules, gives a fast, non-destructive readout, measuring the entire beam profile in a short time interval. It covers a large dynamic range, from less than 10/sup 10/ to over 2 x 10/sup 13/ protons per pulse, when the signal level is adjusted by controlling the local gas pressure and the integrating time. It can see changes in the beam with a time resolution of about 0.1 ms, except at low intensities where longer integration times are needed to get sufficient signal strength. However, the forces due to the space-charge of the circulating beam cause the ions to move in a curved path to the collector, distorting the profile and changing the measured beam size. In the worst situation at the AGS - high current beams at high energy, when the size has damped down to less than 2mm rms width - this distortion is substantial and must be understood and corrected, if possible, to properly interpret the measured beam sizes. This paper develops a model for this distortion, and formulas for correcting it. It is shown that the distortion is more severe than originally recognized, and that accurate quantitative measurements at the highest beam densities in the AGS are not possible. At lower densities, however, the correction is small and the IPM can give a good beam size measurement.
The human 3β-hydroxysteroid dehydrogenase (3β-HSD) gene cluster on chromosome 1p13 contains a presumptive pseudogene; 3β-HSD and CYP17 do not segregate with dominantly inherited hirsutism (1995)

Four hirsute females from a family exhibiting idiopathic dominant hirsutism were examined. Basal blood levels of delta 5 and delta 4 steroids were within the normal range, but ACTH stimulation led to increases in 17-hydroxypregnenolone and dehydroepiandrosterone that were significantly above control levels. Using polymorphic genetic markers, the genes for cytochrome P450c1717 encoded by CYP17, and the type I and II forms of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) were found not to segregate with hirsutism in this family, though a base substitution was detected in the 3' end of exon 1 of the gene for 3 beta-HSD type I in three of the four patients investigated. Analysis of PCR patients amplification products by denaturing gradient gel electrophoresis (DGGE) and sequencing revealed a novel homologue of exon 3 of 3 beta-HSD. DNA of one of the affected patients was used to create a genomic library in lambda gem 11 and clones containing the novel homologue were obtained and partially sequenced. The equivalent clone was obtained from a genomic library of an unrelated normal individual. The sequences of the clones from patient and control were identical and homologous to exons 2-4 of human 3 beta-HSD types I and II. No difference was found in the PCR primer sites that flanked the exons 3 homologue which led to its detection on DGGE gels. In both clones, stop codons and deletions were identified in the exon 4 homologue, leading to the deduction that the sequence comes from a pseudogene, which we call 3 beta-HSD psi 1. The pseudogene mapped to chromosome 1p13. It was concluded that dominantly inherited idiopathic hirsutism in this rare kindred was not due to deficiencies in 3 beta-HSD types I, II, or psi or of CYP17).
Internal Friction of Subnanometer<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>a</mml:mi></mml:math>-Si<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>Films (1995)

In order to determine whether strong interactions between defects are responsible for the spectral distribution of the low energy excitations that are believed to exist in all amorphous solids, we have measured the low temperature internal friction of thin $a$-Si${\mathrm{O}}_{2}$ films with thicknesses ranging from 0.75 to 1000 nm. The internal friction of these films is found to be identical to that of bulk $a$-Si${\mathrm{O}}_{2}$. From this it is concluded that interactions, if significant at all, are limited to distances less than 0.75 nm.
Combinatorial designs and cryptography (1993)

In this expository paper, we describe several applications of combinatorics (in particular, combinatorial designs) to cryptography. We look at four areas in cryptography: secrecy codes, authentication codes, secret sharing schemes, and resilient functions. In each of these areas, we find that combinatorial structures arise in a natural and essential way, and we present several examples of combinatorial characterizations of cryptographic objects.
Introduction (1983)

Threadbare by now from quarter of a century of quotation, these words still provide journalists with a theme, irritate admirals, perplex Ministers of Defence and await a comprehensive answer.KeywordsNuclear WeaponBritish IsleEuropean Economic CommunityStrategic ThoughtMilitary CapabilityThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Psychological Stress and Antibody Response to Immunization: A Critical Review of the Human Literature (2001)

The literature supports a relationship between psychological stress and antibody responses to immunizations. The data are convincing in the case of secondary response but weak for primary response. More attention to the kinetics of stress and antibody response and their interrelations is needed in future research.
The<i>Saccharomyces cerevisiae YCC5</i>(YCL025c) Gene Encodes an Amino Acid Permease, Agp1, Which Transports Asparagine and Glutamine (1998)

The yeast YCC5 gene encodes a putative amino acid permease and is homologous to GNP1 (encoding a high-affinity glutamine permease). Using strains with disruptions in the genes for multiple permeases, we demonstrated that Ycc5 (which we have renamed Agp1) is involved in the transport of asparagine and glutamine, performed a kinetic analysis of this activity, and showed that AGP1 expression is subject to nitrogen repression.
Quantum cryptography without Bell’s theorem (1992)

Ekert has described a cryptographic scheme in which Einstein-Podolsky-Rosen (EPR) pairs of particles are used to generate identical random numbers in remote places, while Bell's theorem certifies that the particles have not been measured in transit by an eavesdropper. We describe a related but simpler EPR scheme and, without invoking Bell's theorem, prove it secure against more general attacks, including substitution of a fake EPR source. Finally we show our scheme is equivalent to the original 1984 key distribution scheme of Bennett and Brassard, which uses single particles instead of EPR pairs.
Methods of flow measurement in well bores (1962)

Schematic diagram of Au deep-well current meter and recording circuit ___________________________________________ 12
The splenic form of mantle cell lymphoma (2002)

We conclude that this presentation represents a separate form of MCL which requires splenectomy. It remains to be seen whether it carries a better prognosis than classical MCL.
The Polysaccharide Portion Plays an Indispensable Role in<i>Salmonella</i>Lipopolysaccharide-Induced Activation of NF-κB through Human Toll-Like Receptor 4 (2002)

The lipid A portion has been identified as the active center responsible for lipopolysaccharide (LPS)-induced macrophage activation. However, we found that Salmonella (Salmonella enterica serovars Abortusequi, Minnesota, and Typhimurium) lipid A is inactive in human macrophages, despite its LPS being highly active. Thus we investigated the critical role of polysaccharide in Salmonella LPS-induced activation of NF-kappaB. In human monocytic cell line THP-1, Salmonella lipid A and synthetic Salmonella-type lipid A (516) did not induce NF-kappaB-dependent reporter activity up to 1 micro g/ml, whereas strong activation was observed in response to Salmonella LPS. The difference in activity between this lipid A and LPS was further examined by using 293 cells expressing human CD14/Toll-like receptor 4 (TLR4)/MD-2, and similar results were obtained in these cells as well. A polysaccharide preparation obtained from Salmonella LPS was inactive in 293 cells expressing human CD14/TLR4/MD-2 even in combination with 516. Salmonella enterica serovar Minnesota Re LPS, whose structure consists of lipid A and two molecules of 2-keto-3-deoxyoctonic acid, but not its lipid A exhibited strong activity in THP-1 cells and 293 cells expressing human CD14/TLR4/MD-2. These results indicate that the polysaccharide portion covalently bound to lipid A plays the principal role in Salmonella LPS-induced activation of NF-kappaB through human CD14/TLR4/MD-2.
A ASSISTÊNCIA DE ENFERMAGEM AO PACIENTE TERMINAL EM UNIDADE DE TERAPIA INTENSIVA (UTI) (2013)

O estudo observa como a assistencia de enfermagem esta sendo ofertada ao paciente terminal de uma unidade de terapia intensiva (UTI), com isso analisar os aspectos que envolvem o profissional enfermeiro na assistencia ao paciente terminal. Assim tambem podemos verificar quais as reacoes que um tratamento intensivo tem desenvolvido no paciente, na familia e equipe de enfermagem. Se os cuidados ofertados, sao de qualidade e preservam a etica o cuidado de enfermagem, aliando sempre com as novas tecnologias e buscando sempre o melhor para o paciente e seus familiares. No entanto torna-se possivel identificar como a classe da enfermagem vem oferecendo dia apos dia, a dignidade aos pacientes terminais e investindo sempre na melhora dele, mesmo que seja em um curto periodo de vida que lhe resta.
<i>In vitro</i>sensitivity of human and environmental strains of<i>Cryptococcus neoformans</i>to micronized hamycin (1969)

A micronized preparation of Hamycin, a polyene heptaene antibiotic, was tested in vitro against 25 strains of Cryptococcus neoformans isolated from patients and environmental sources. Minimum inhibitory concentration varied from 0·005–0·06 μg./ml. An apparent increase in m.i.c. was observed as the hamycin “aged” in suspension form over longer period of incubation. This was probably due to the deterioration of the antibiotic resulting in decreased fungistatic activity. Une préparation micronisée d'Hamycin, antibiotique polyène heptaène, est éprouvée avec 25 souches de Cryptococcus neoformans isolées de malades ou du milieu situé dans l'environnement de ceux-ci. La concentration minimum inhibitrice varie de 0,005 à 0,06 μg./ml. Une augmentation manifeste de cette concentration s'observe lors du vieillissement de la suspension pendant des périodes de plus en plus longues. Ce fait est probablement dû à la détérioration de l'antibiotique, qui provoque une baisse de l'activité fongistatique.
Indicating Media Features for MIME Content (2000)

In A Syntax for Describing Media Feature Sets, an expression format is presented for describing media feature capabilities using simple media feature tags.
Distribution of Rubber and Resins in Guayule (1947)

Rubber contents are so frequently the focus of attention in investigations of guayule (Parthenium argent at urn Gray) that an account of rubber distribution in the plant may contribute to experimental studies as well as to purely descriptive literature concerning the plant. In the choice of plant ,material for study or for sampling, or in the interpretation of results, the relative amounts and concentrations of rubber in the various parts may be a pertinent factor. Even commercial scale harvesting and milling operations are aided to some degree by knowledge of which plant parts contribute significantly to rubber yields and which are insignificant or mere diluents. The pattern of rubber distribution as revealed qualitatively under the microscope has been thoroughly studied and described by Ross (8), Lloyd (6) and Artschwager (1). In plants older than one year, the vascular rays of phloem and xylem carry the major portion of the rubber. Other parenchymatous tissues, the pith, primary cortex, epithelial cells of the resin canals, and xylem parenchyma contain rubber; but, partly because they comprise a smaller fraction of the plant, the amount of rubber they contribute is less important. In younger plants, some of these latter tissues contribute a relatively larger part of the total rubber. Rubber is evident in the leaf parenchyma, but only in very small amounts. Only incomplete information is to be found concerning the macro-, but quantitative distribution of rubber in guayule. Whittlesey (13) separated several portions from native plants of uncertain but evidently advanced age. As determined by carbon tetrachloride extraction, following extraction with alcohol and water, the bark of the root and that of the trunk yielded approximately 20% rubber. Practically no rubber was obtained from the wood of these parts. This supported an impression, already current at that time, that the rubber in guayule is largely restricted to the bark. Above the trunk, which was apparently the sole remnant of the basal branching system typical
Applied Probability and Queues. (1987)

This book treats the mathematics of queueing theory and some related areas, as well as the basic mathematical tools for the study of such models.It thus aims to serve as an introduction to queueing theory, to provide a thorough treatment of tools such as Markov processes, renewal theory, random walks, Lévy processes, matrix-analytic methods and change of measure, and to treat in some detail basic structures such as the GI/G/1 and GI/G/s queues, Markov-modulated models, queueing networks, and models within the areas of storage, inventory and insurance risk.Within this framework the choice of topics is, however, rather traditional.The aim has been to present what I consider the basic knowledge in the area, not to advocate special directions in which the area is at present developing.The first edition was published in 1987.This second edition incorporates about 100 extra pages containing an extended treatment of queueing networks and matrix-analytic methods as well as a number of additional topics, in particular Poisson's equation, the fundamental matrix, insensitivity, rare events and extreme values for regenerative processes, Palm theory, rate conservation, Lévy processes, reflection, Skorokhod problems, Loynes's lemma, Siegmund duality, light traffic, heavy tails, the Ross conjecture and ordering, and finite buffer problems.Also, the references, typically given in the Notes following the separate sections, have been thoroughly updated.It should be noted, however, that these Notes are mainly intended as a first guidance for further reading, not as a bibliography or history of the subject.When a textbook or a survey paper dealing with a topic is available, this is the preferred reference rather than the original papers.Thus, details of priority are treated rather sporad-
The abundance and distribution of intertidal invertebrates, and an estimation of their selection by Shelduck (1982)

A study was made to estimate prey selection by wintering Shelduck Tadorna tadorna foraging on the intertidal flats of the Clyde Estuary. This involved sampling from craters which had been formed by the dabbling feeding action of Shelduck. Assays of invertebrates from sediments which had passed through the bill and from undisturbed sediments showed there was general selection for invertebrates just greater than 2.0 mm long. Small worms, especially Tubifex costatus, constituted the patchiest and greatest biomass component available, and were assessed prevalent in the diet. Simple calculation showed broad agreement between an estimation for intake of Hydrobia ulvae and its known inclusion in stomach contents. There was no association between feeding intensity and abundance of any single prey species or with any particle size range. A negative relationship between durations of feeding and intervening movement was apparent, suggesting that continual exploitation of a patchy resource was accompanied by a reduction in travel times.
Impact analysis—the social audit approach (1988)

Social audit techniques have been used increasingly during the 1980s recession. They representan important means of extending impact assessment into the area of community social and economic costs. In this paper some of the experience of recent work in this field is discussed, concentrating on matters of continuing major debate. The discussion is taken further by considering how social audit techniques might have to be broadened to cater for new project proposals, in the process providing some useful additional areas for examination applicable to all social audits.