gebhart/patrepeval huggingface dataset:
Sweating in hot baths (1961)

Sweating of human volunteers immersed to the neck in hot water declined markedly after reaching a peak in the 1st hr of exposure. This decline always occurred in fresh water regardless of level of thermal stress. Sweating in the 3rd hr of exposure was about the same whether the water was hot in the 1st 2 hr (sweat glands active) or cool (sweat glands inactive). Thus “fatigue” was not responsible for the decline. It is suggested that observations of decline of sweating in warm-humid air environments, attributed to “sweat gland fatigue,” in reality may have been owing to soaking of the skin with sweat. The mechanism of suppression appears more complex than blockage of the sweat ducts by swelling of the corneum. Rather, there is an association between the amount of decline and conditions favoring diffusion of water to deeper strata of the skin. For example, adding salt to the water reduced the decline; no decline occurred in 15% NaCl. Submitted on March 6, 1961
S2093 INTERSOMATIC GRAFTS BY ANTERIOR APPROACH AS A TREATMENT OF SEPTIC LUMBAR FUSION FAILURES (2004)

Introduction Infection of posterior instrumentation supposes a severe failure in long arthrodeses with a demineralized skeleton. Materials and methods From 1998 to 2002, ten patients of 19 to 76 years (mean 56 years) have been grafted with anterior Peek cages filled with autograft. Four cases of scoliosis were operated as an average 5 times by posterior approach (3 – 9 times), all of them suffered fistulised non-unions recidivating after every one of the previous operations. 4 times the germ xas a Staph. Aureus Met. resist (1 associated with a streptococcus and 2 of them with an enterococcus). Three patients presented severe radicular pain. Six posttraumatic cases underwent a surgical extraction of the posterior instrumentation. All of them presented a non-union with total loss of the initial angular correction. In one case the septic destabilisation affected the level proximal to the fixation. The germ responsible was every time a Staph. Aureus Met. Res. with an enterococcus associated in one of the cases. Two inveterate fistulae were operated before. The grafts were performed on 1 to 4 levels without a new posterior fixation but in one case (5 thoracolumar approaches, 5 on lumbosacral fusions, external support by a 3 points corset between 4–6 months). The postoperative antibiotherapy has been maintained for 4 months in average (3–12 mos). The fusion was appreciated by the graft aspect on CT scan with a mean follow-up of 22 months (12 months minimum). Results: No anterior infection has been observed, but in one post-traumatic case with a violation of the discal space by a screw. (Flare-up of the infection without anterior collection, treated by a new posterior approach with definitive kyphotic fusion as a result). All the nine others fused with clinical improvement (sevrance of the rigid corset and decreasing analgesic doses in a mean time of six months) and without significant correction loss. Three cases of radicular pain improved too. As a complication, one female patient previously operated three times by an anterior approach, was operated a new by a minimal left approach without incidents. She suffered in the postoperative period an ureteral necrosis needing a secondary nephrectomy. Conclusion This strategy of intersomatic graft is a recovering solution in the mechanical failures of severe and reccurrent infections, often germs association. With these severe deformities on aged patients this technique is more difficult. The positive culture of disc material is a bad prognostic factor. In case of previous anterior approach, it is a good procedure the catheterisation of the ureteral duct to prevent a possible necrosis. The intersomatic cage has been a safe procedure assuring a primary and late stability in those patients with a deficient bone-stock. The cages did not induced any additionnal septic problems.
Assembly of Bio-Nanoparticles for Double Controlled Drug Release (2013)

A critical limiting factor of chemotherapy is the unacceptably high toxicity. The use of nanoparticle based drug carriers has significantly reduced the side effects and facilitated the delivery of drugs. Source of the remaining side effect includes (1) the broad final in vivo distribution of the administrated nanoparticles, and (2) strong basal drug release from nanoparticles before they could reach the tumor. Despite the advances in pH-triggered release, undesirable basal drug release has been a constant challenge under in vivo conditions. In this study, functionalized single walled carbon nanohorn supported immunoliposomes were assembled for paclitaxel delivery. The immunoliposomes were formulated with polyethylene glycol, thermal stable and pH sensitive phospholipids. Each nanohorn was found to be encapsulated within one immunoliposome. Results showed a highly pH dependent release of paclitaxel in the presence of serum at body temperature with minimal basal release under physiological conditions. Upon acidification, paclitaxel was released at a steady rate over 30 days with a cumulative release of 90% of the loaded drug. The drug release results proved our hypothesized double controlled release mechanism from the nanoparticles. Other results showed the nanoparticles have doubled loading capacity compared to that of traditional liposomes and higher affinity to breast cancer cells overexpressing Her2 receptors. Internalized nanoparticles were found in lysosomes.
Preparation, Resolution, and Biological Evaluation of 5-Aryl-1,2-dihydro-5<i>H</i>-chromeno[3,4-<i>f</i>]quinolines:  Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists (1998)

Two potent nonsteroidal progestins from the 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinoline class (LG120746 and LG120747) were selected for scale-up, resolution, and biological evaluation of the purified enantiomers. For each quinoline, the levorotatory enantiomer was determined to be the more potent agonist of the human progesterone receptor isoform B (hPR-B) (EC50 < 3 nM), but the dextrorotatory enantiomers retained significant PR modulatory activity (EC50 < 200 nM). In two in vivo rodent models of progestational activity, a pregnancy maintenance assay and a uterine wet weight assay, the two eutomers displayed potent progesterone-like effects. In a third model for progestational activity, the mammary end bud assay, these compounds were significantly less active. These studies demonstrate that certain members of this class of selective progesterone receptor modulators display encouraging and potentially useful tissue-selective progestational effects.
2P1-P11 The amount presumption of the individual features by the form data using a depth image sensor(Digital Human) (2012)

A service robot can provide the advanced service suitable for the person by not only recognizing people, but also identifying and classifying people. Therefore, in this study, a classification of people and identification function are realized by computing the amount of the features which expresses a form from people's size. I performed a multiple regression analysis from the measure of human body which can be presumed from KinectSDK to the "individual feature quantity" extracted from measure of human body data using principal component analysis. As a result, it was shown that the first main ingredients of individual feature quantity can be expressed by the contribution of 88.9%, and the second main ingredients can be expressed by the contribution of 76.1%.
A study to improve the mechanical properties of silicon carbide ribbon fibers (1976)

Preliminary deposition studies of SiC ribbon on a carbon ribbon substrate showed that the dominant strength limiting flaws were at the substrate surface. Procedures for making the carbon ribbon substrate from polyimide film were improved, providing lengths up to 450 meters (1,500 ft.) of flat carbon ribbon substrate 1,900 microns (75 mils) wide by 25 microns (1 mil) thick. The flaws on the carbon ribbon were smaller and less frequent than on carbon ribbon used earlier. SiC ribbon made using the improved substrate, including a layer of pyrolytic graphite to reduce further the severity of substrate surface flaws, showed strength levels up to the 2,068 MPa (300 Ksi) target of the program, with average strength levels over 1,700 MPa (250 Ksi) with coefficient of variation as low as 10% for some runs.
Phosphorous coimplantation effect on threshold voltage uniformity of GaAs transistors (1989)

Phosphorous coimplantation effect on electrical uniformity of Si-implanted GaAs active layer is investigated for undoped as-grown, undoped ingot-annealed, and In-doped substrates. Pairs of field-effect transistors, fabricated with and without P coimplantation, are placed on whole 3-in.-diam substrates at a 200-μm interval. Threshold voltage measurements reveal that a concentration of 1018 /cm3 coimplanted P reduces the standard deviation in threshold voltage for undoped as-grown substrates to 1/2.5. Undoped ingot-annealed substrates achieve the same uniformity of threshold voltage as In-doped substrates, which showed the best data. Moreover, this method reduces the variation in the mean threshold voltage among substrates by one-half. These results indicate that P coimplantation successfully suppresses the change of As to Ga vacancy concentration ratio.
Das Relativitätsprinzip in der klassischen Mechanik (2018)

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The importance of MHC‐I and MHC‐II responses in vaccine efficacy against lethal herpes simplex virus type 1 challenge (1997)

To investigate the importance of major histocompatability complex (MHC) class I- and MHC class II-dependent immune responses in herpes simplex virus-1 (HSV-1) vaccine efficacy, groups of beta 2% (MHC I-) and Ab% (MHC II-) mice were inoculated with various vaccines, and then challenged intraperitoneally with HSV-1. Following vaccination with either live avirulent HSV-1, expressed HSV-1 glycoprotein D (gD), or a mixture of seven expressed HSV-1 glycoproteins (7gPs), Ab% (MHC-II-) mice developed no enzyme-linked immunosorbent assay (ELISA) or neutralizing antibody titres. In contrast, significant ELISA and neutralizing antibody titres were induced in beta 2m% (MHC-I-) mice by all three vaccines. The neutralizing antibody titres were similar for all three vaccines, but were only approximately 1/4 to 1/3 of that developed in C57BL/6 (parental) mice vaccinated with the same antigens. All three vaccines protected 100% of the wild-type C57BL/6 mice against lethal challenge with 2 x 10(7) plaque-forming units (PFU) of HSV-1. The live virus vaccine and the 7gPs vaccine also protected 80% of the beta 2m% mice against the same lethal HSV-1 challenge dose. In contrast, in Abo/o mice, none of the vaccines provided significant protection against the same lethal challenge dose of HSV-1. However, at a lower challenge dose of 2 x 10(6) PFU, all three vaccines protected 70-80% of the vaccinated Ab% mice (compared to only 10% survival in mock vaccinated controls). Thus, vaccination provided some protection against lethal HSV-1 challenge in both beta 2m% and Ab% mice; however, the protection was less than that seen in the parental C57BL/6 mice. In addition, Ab% mice were less well protected by vaccination than were beta 2m% mice. Our results suggest that (1) both MHC-I and MHC-II are involved in vaccine efficacy against HSV-1 challenge; (2) both types of responses must be present for maximum vaccine efficacy: and (3) the MHC-II-dependent immune response appeared to be more important than the MHC-I-dependent immune response for vaccine efficacy against HSV-I challenge.
Azetidinone antibiotics. XII. Chemical transformations of penicillins and cephalosporins. Mechanism and stereochemistry of the interconversions of penam and cepham systems (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzetidinone antibiotics. XII. Chemical transformations of penicillins and cephalosporins. Mechanism and stereochemistry of the interconversions of penam and cepham systemsS. Kukolja, S. R. Lammert, M. R. Gleissner, and A. I. EllisCite this: J. Am. Chem. Soc. 1975, 97, 11, 3192–3198Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/ja00844a045https://doi.org/10.1021/ja00844a045research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors (2010)

Combination therapy with sunitinib administered on Schedule 2/1 (50 mg/day) or a CDD schedule (37.5 mg/day) together with standard-dose pemetrexed (500 mg/m(2)) was well tolerated in previously treated patients with advanced solid tumors.
Strain and Vector-Magnetic-Field Tuning of the Anomalous Phase in Sr3Ru2O7 (2015)

Article published in Science Advances, https://doi.org/10.1126/sciadv.1501804
Two-layer sliding mode control of pneumatic position synchro system with feedback linearization based on friction compensation (2008)

Pneumatic systems have been widely used in industrial applications because of their well-known advantages. However, pneumatic systems have disadvantages that include strong non-linearity and low natural frequency. These drawbacks make it difficult to obtain satisfactory control performances in comparison to hydraulic systems. In this paper, the fundamental characteristics and nonlinear control strategy of the pneumatic system is studied. The two-layer sliding mode synchro system with feedback linearization based on friction compensation is applied to electro-pneumatic synchro position system. To verify the used strategies, experiments with the synchro system are performed. The experimental results show that the new designed controller is effective for both accuracy and robustness.
Agricultural mitigation of greenhouse gases: Science and policy options (2001)

The focus of a forthcoming Council on Agricultural Science and Technology (CAST) report is to summarize and synthesize the most recent research on the potential to mitigate GHG emissions through improvements in agricultural and land management practices. The report is designed to inform policy and decision makers in government and industry, agricultural producers, environmental and other nongovernmental organizations, and the general public. A major objective of the report has been to bring together biophysical and ecological information with economics and policy analysis, to provide a clearer picture of the potential role of agriculture in GHG mitigation strategies. In addition, a major aim has been to address all three major greenhouse gases and to consider the potential tradeoffs and/or synergisms between practices aimed at carbon sequestration and mitigation of N2O and CH4 emissions, in order to understand the net effect of all three gases (CO2, N2O and CH4), which can be expressed as an aggregate global warming potential (GWP) value. It is hoped that this synthesis will inform the debate on GHG mitigation in ongoing national and international efforts to deal with global climate change. This paper presents a brief synopsis of some of the findings of the CAST report.
Dual site ambulatory pH monitoring: a probe across the lower esophageal sphincter does not induce gastroesophageal reflux. (1996)

Our study results indicate that placement of a 2.1-mm diameter pH probe across the LES does not induce reflux in asymptomatic healthy volunteers or in patients with GERD. Dual site ambulatory pH monitoring with trans-sphincteric pH catheter placement is a valid diagnostic technique that can be applied clinically when required.
Circuits for three-channel stereophonic playback derived from two sound tracks (1959)

Derivation of a third playback channel from two stereo sound tracks may be accomplished by several means. The center channel may be derived by recombination prior to power amplification; acoustically, after amplification, by using two center speakers; and in a variety of phase relationships, including the limiting case of equal signals (monophonic) in which either sum or difference combination may be chosen by polarity selection.
Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy (2009)

By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.
<title>Potential of dry etching for the fabrication of fused silica micro-optical elements</title> (1999)

We report on recent progress in the fabrication of fused silica micro-optical elements, such as blazed gratings, refractive microlenses and microprisms. The elements are first made in photoresist and then they are transferred into fused silica by reactive ion etching. High selectivity etching is needed to realize structures with a high aspect ratio. Results are shown using various metallic etch masks. The shaping of optimized profiles is also presented to generate microlenses which are aspheric, or which have a low numerical aperture.
Captopril‐enhanced binding of PlA1 (HPA‐1a) antibodies in posttransfusion purpura (1991)

A case of posttransfusion purpura is reported in a 90-year-old patient whose PlA1 antibody (anti-HPA-1a) was found to bind better to HPA-1a in the presence of captopril, a drug the patient had taken. Initially, IgG antibodies were found in the serum that reacted with normal platelets, but the binding of the antibody was increased in vitro by captopril, which suggested that captopril was responsible for the thrombocytopenia. However, in vitro studies demonstrated that the patient's platelets were negative for HPA-1a and that anti-HPA-1a was present in the serum, both of which findings were consistent with the diagnosis of posttransfusion purpura. The binding of this antibody was enhanced 50 percent by captopril in vitro, and increased binding in the presence of captopril did not occur when the anti-HPA-1a was removed. Similar results were obtained with serum containing anti-HPA-1a from another patient with posttransfusion purpura. Thus, captopril may increase the binding of anti-HPA-1a and confuse the determination of the cause of acute thrombocytopenia.
Performance Optimization of Dynamic Wireless EV Charger Under Varying Driving Conditions Without Resonant Information (2019)

On-road dynamic charging of electric vehicles by wireless power transfer (WPT) systems has emerged recently as a cost-saving means for modern transportation. Thus, maximizing power transfer efficiency is essential in the system design stage as well as during the operation. In addition, the voltage regulation of EV power bus, supplied by the power transfer system and battery, is needed for a long life of the battery. In this paper, these two requirements are fulfilled under varying EV driving conditions by a single control system applied to a wireless power transfer system. The control system simultaneously tunes the switching frequency of the primary side inverter and the conversion ratio of the secondary side converter to achieve the maximum possible efficiency. In addition, the system adjusts the duty cycle of the primary side inverter to regulate the output voltage. Furthermore, an allowable range for the optimal frequency is determined and imposed to the primary inverter to compensate the power factor reduction according to IEEE std-1547.1. The system needs just one dc/dc converter instead of two as reported in the literature, without any restriction in zero state and start-up conditions. The control system does not need any information of the coupling coefficient and compensating circuit elements. The system is applied to a 710 W experimental wireless power transfer setup. Extensive simulation and experimental results are presented to validate the proposed control system.
Increased local IgE production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic, but not non‐eosinophilic, chronic rhinosinusitis with nasal polyps (2014)

The local IgE induced by common aeroallergens may mediate mast cell activation and contribute to subsequent eosinophilic inflammation in Chinese CRSwNP. This study offers a rationale for considering intervention strategies designed to target 'local allergy' in eosinophilic CRSwNP.
Ni and Ti Schottky barriers on n-AlGaN grown on SiC substrates (1998)

The electrical characteristics of Ni and Ti Schottky barriers on n-Al0.15Ga0.85N on SiC were investigated. We report that the barrier height for Ni on n-Al0.15Ga0.85N was about 1.26 eV and about 1 eV or less for Ti. These barrier heights are about 0.3–0.4 eV larger than those for Ni and Ti on n-GaN, which are in good agreement with Schottky model predictions.
Multiscale modeling of RNA 3D structures (2013)

Balancing accuracy and computational efficiency while studying biomolecular structures and dynamics necessitates scalable modeling techniques. We have been developing a coarse-grained model for RNA that uses pseudoatoms in place of all-atom representation. By reducing the number of interactions and mean-field representation of environmental effects, significant improvement in computational efficiency is achieved in a comparison to all-atom based physical modeling approaches. A five bead coarse-grained model utilized for RNA 3D structure prediction is presented. Unique features of this framework include the direct mapping between all atom and coarse-grained models, incorporation of electrostatic interactions, continuous and analytical energy function that can be used in molecular dynamics simulations, and statistical derived parameters. Here we present the basic framework of our model and recent applications to RNA folding.