gebhart/patrepeval huggingface dataset:
The effect of influenza vaccination on trained immunity: impact on COVID-19 (2020)

ABSTRACT Every year, influenza causes 290.000 to 650.000 deaths worldwide and vaccination is encouraged to prevent infection in high-risk individuals. Interestingly, cross-protective effects of vaccination against heterologous infections have been reported, and long-term boosting of innate immunity (also termed trained immunity ) has been proposed as the underlying mechanism. Several epidemiological studies also suggested cross-protection between influenza vaccination and COVID-19 during the current pandemic. However, the mechanism behind such an effect is unknown. Using an established in-vitro model of trained immunity, we demonstrate that the quadrivalent inactivated influenza vaccine used in the Netherlands in the 2019-2020 influenza season can induce a trained immunity response, including an improvement of cytokine responses after stimulation of human immune cells with SARS-CoV-2. In addition, we found that SARS-CoV-2 infection was less common among Dutch hospital employees who had received influenza vaccination during the 2019/2020 winter season (RR = 0,61 (95% CI, 0.4585 - 0.8195, P = 0.001). In conclusion, a quadrivalent inactivated influenza vaccine can induce trained immunity responses against SARS-CoV-2, which may result in relative protection against COVID-19. These data, coupled with similar recent independent reports, argue for a beneficial effect of influenza vaccination against influenza as well as COVID-19, and suggests its effective deployment in the 2020-2021 influenza season to protect against both infections.
Tissue-Engineered Skin Substitutes Using Collagen Scaffold with Amniotic Membrane Component (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A Bioactive <i>seco</i>-Rosane Diterpenoid from <i>Vellozia candida</i> (1997)

Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.
HLA specificities are related to development and prognosis of diffuse large B-cell lymphoma (2013)

Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease influenced by genetic and environmental factors. The role of the HLA system in tumor antigen presentation could be involved in susceptibility and disease control. We analyzed the phenotypic frequencies of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 in 250 DLBCLs, comparing them with 1940 healthy individuals. We also evaluated the influence of HLA polymorphisms on survival in those patients treated with curative intention using cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP)-like regimen without (n = 64, 26%) or with (n = 153, 61%) rituximab. DLBCL patients have a higher phenotypic frequency of HLA-DRB1*01 (29% vs 19.5%, P = .0008, Pc = .0104) and a lower frequency of HLA-C*03 (6.4% vs 17.9%, P < .0005, Pc = .007) compared with healthy individuals. Irrespective of the age-adjusted International Prognostic Index, those patients receiving a CHOP-like plus rituximab regimen and carrying the HLA-B44 supertype had worse 5-year progression-free (54% vs 71%, P = .019) and 5-year overall (71% vs 92%, P = .001) survival compared with patients without this supertype. Our data suggest that some HLA polymorphisms influence the development and outcome of DLBCL, allowing the identification of an extremely good-risk prognostic subgroup. However, these results are preliminary and need to be validated in order to exclude a possible population effect.
Suppressing non‐Gaussian noises with scaled receiver wavefield for reverse‐time migration: comparison of different approaches (2013)

ABSTRACT Numerical implementation of the gradient of the cost function in a gradient‐based full‐ waveform inversion (FWI) is essentially a migration operator used in wave equation migration. In FWI, minimizing different data residual norms results in different weighting strategies of data residuals at receiver locations prior to back‐propagation into the medium. In this paper, we propose different scaling methods to the receiver wavefield and compare their performances. Using time‐domain reverse‐time migration (RTM), we show that compared to conventional algorithms, this type of scaling is able to significantly suppress non‐Gaussian noise, i.e., outliers. Our tests also show that scaling by its absolute norm produces better results than other approaches.
Scattering times and mean free path in AlCuFe quasicrystalline thin films (1995)

We present magnetoresistivity measurements on AlCuFe quasicrystalline thin films from which the temperature dependence of the inelastic scattering time (${\mathrm{\ensuremath{\tau}}}_{\mathrm{ie}}$) has been deduced down to 200 mK in the low field limit. We show that ${\mathrm{\ensuremath{\tau}}}_{\mathrm{ie}}$ presents a weak temperature dependence below 4 K (1/${\mathrm{\ensuremath{\tau}}}_{\mathrm{ie}}$\ensuremath{\sim}${\mathit{T}}^{0.87}$) which is in close agreement with the theory of Isawa predicting a crossover from a ${\mathit{T}}^{3/2}$ to a T regime. Saturation effects as well as a possible shift in dimensionality have also been investigated.
Survival of Larval Giant Tiger Prawns<i>Penaeus monodon</i>after Addition of Killed Vibrio Cells to a Microencapsulated Diet (1991)

Feeding trials were conducted with microencapsulated test diets supplemented with formalinkilled vibrio cells to increase the number of survivors and to improve the quality of larvae in an early developmental stage of the giant tiger prawn Penaeus monodon. Vibrio cells were added at a level of 0.05, 0.5, or 5%, and the mixture was encapsulated with gelatin by a spray-dry method. Larvae at the zoeal stage were fed the test diet for four consecutive days. The survival of larvae as a percentage of initial larvae was higher in the groups fed bacterial cells than in the control group (P < 0.01 or P < 0.05).
Development and Application of Constitutive Models for the Plasticity of Metals (2001)

The macroscopic behaviour of crystalline materials under mechanical or thermal loadings is determined by processes in the microregion of the material. By a combination of models on the basis of molecular dynamics and cellular automata, it seems possible to simulate numerically the formation of internal structures during the deformation processes. The stochastical character of these mechanisms can be considered by modelling them as stochastic processes, which result in Markov chains. By a mean value formulation, this leads to a macroscopic model consisting of non-linear ordinary differential equations. The determination of the unknown material parameters is based on a Maximum- Likelihood output-error method comparing experimental data to the numerical simulations. With Finite-Element methods, it is possible to use the material models for the design of components and structures in all fields of technical application and for the numerical simulation of their behaviour under complex loading situations.
Supercontinuum generation beyond 2 <i>µ</i>m in GeO<sub>2</sub>fiber: comparison of nano- and femtosecond pumping (2015)

Experimental and theoretical comparison of supercontinuum generation for femtosecond and nanosecond pulses with similar peak power level in the same nonlinear media was provided. In the case of femtosecond pumping, we observed a number of peaks and in the case of nanosecond pulses, we observed a continuous spectrum.
Kinetically Controlled Synthesis of Hexagonally Close‐Packed Cobalt Nanorods with High Magnetic Coercivity (2009)

Abstract High‐quality monodisperse metallic cobalt nanorods are obtained by the reduction of carboxylate salts of Co II in 1,2‐butanediol using a rapid, simple, and solid‐template‐free procedure. In this polyol process, particle shape can be controlled via the growth rate, which depends on three parameters: i) the nature of the cobalt carboxylate, ii) the temperature ramp, and iii) the basicity of the medium. Cobalt in the hexagonally close‐packed phase favored the growth of anisotropic particles. Magnetic measurements of the cobalt nanorods indicate they are ferromagnetic at room temperature. They have a very high coercivity of 9.0 kOe at 140 K, much higher than that observed for wires prepared with solid templates. This can be attributed to their small mean diameter and high crystallinity.
Non-ionic surfactants and gastric mucosal transport of paraquat (1981)

The influence of a range of polyoxyethylated non-ionic surfactants upon the transport of [14C]-paraquat dichloride across rabbit isolated gastric mucosa was investigated. Paraquat was shown to cross the mucosal epithelium by passive diffusion. Certain members of the surfactant series enhanced transmucosal paraquat transfer at low surfactant concentrations (e.g. 0.001%) but the occurrence and magnitude of this effect was not dependent in a simple manner upon surfactant structure of physiochemical properties. At micellar concentrations the increase in paraquat transport was greatest with those surfactants possessing both ethylene oxide chains of 10-20 units and alkyl chains longer than C7-C9. The most effective absorption promoter was found to be Brij 36T (C12E10). At micellar surfactant concentrations the enhancement of paraquat transfer appeared, from histological evidence, to be related to the ability of the surfactants to solubilize membrane components and disrupt epithelial cells.
Metal Phosphinylides and Phosphinothioylides. II. Effects of Metals on the Reactions of [Ph2PX]M with Benzaldehyde and <i>p</i>-Benzoquinone (1974)

Abstract Reactions of [Ph2PO]M with benzaldehyde gave benzyl benzoate and benzyldiphenylphosphine oxide (3) in the case of M=Na, 3, α-hydroxybenzyldiphenylphosphine oxide, benzyl alcohol, benzoin and benzil in the case of M=MgCl, and 3 in the case of M=ZnCl. Reactions of [Ph2PX]M with p-benzoquinone gave 2,5-dihydroxyphenyldiphenylphosphine oxide or sulfide and p-hydroxyphenyl diphenylphosphinate in the cases X=O, S and M=Li, MgCl, Al, and 1,4-phenylene bis(diphenylphosphinate) or bis(diphenylphosphinothioate) in the cases X=O, S and M=FeCl. The reaction mechanisms have been discussed.
A Model Study of the Synthesis of the A Ring of Gibberellic Acid<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Model Study of the Synthesis of the A Ring of Gibberellic Acid1Lloyd J. Dolby and Robert J. MilliganCite this: J. Am. Chem. Soc. 1966, 88, 19, 4536–4537Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October 1966https://pubs.acs.org/doi/10.1021/ja00971a062https://doi.org/10.1021/ja00971a062research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A cancer therapeutic nanoparticle vaccine targeting HAAH improves 3-week survival from 12.5% to 100% in a mouse model of metastatic breast cancer (2014)

Meeting abstracts Human aspartyl (asparaginyl) β-hydroxylase (HAAH) is over-expressed on the surface of cancer cells. It is an embryonic protein that is demonstrated to be responsible for cancer etiology: cell proliferation, motility and invasiveness. When normal cells are transfected to over-
<title>Pyramid-Based Extraction Of Local Image Features With Applications To Motion And Texture Analysis</title> (1983)

Multi-resolution pyramid structures may be used to compute image properties efficiently and within sets of Gaussian-like windows of many sizes. We define several basic pyramid algorithms which may be applied to a variety of image understanding tasks. These include a multi-resolution low-pass filter (the Gaussian pyramid), a multi-resolution band-pass filter (the Laplacian pyramid) and a multiscale window function (the Hierarchical Discrete Correl-ation). To illustrate these algorithms we present procedures for computing local edge density and spectral energy estimates for texture discrimination, and procedures for computing local correlation and gradient based estimates of pattern displacement for motion analysis. Pyramid computations are shown to be particularly low in both cost and complexity.
Cyr61 mediates the expression of VEGF, α<sub>v</sub>-integrin, and α-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells (2005)

Application of cyclic strain to bladder smooth muscle (SM) cells results in profound alterations of the histomorphometry, phenotype, and function of the cells. The onset of this process is characterized by the activation of a cascade of signaling events coupled to progressive and, perhaps, interdependent changes of gene expression. In particular, externally applied cyclic stretch to cultured bladder SM cells results in the transient expression of the Cyr61 gene that encodes a cysteine-rich heparin-binding protein originally described as a proangiogenic factor capable of altering the gene programs for angiogenesis, adhesion, and extracellular matrix synthesis. In this study, we investigated the effects of mechanical stretch-induced Cyr61 on the expression of potential mechanosensitive Cyr61 target genes and the signaling pathways involved. We showed that suppression of Cyr61 expression with an adenoviral vector encoding an antisense oligonucleotide reduced mechanical strain-induced VEGF, alpha(v)-integrin, and SM alpha-actin gene expression but had no effect on the myosin heavy chain isoforms SM-1 and SM-2. Signaling pathways involving RhoA GTPase, phosphatidyl inositol 3-kinase, and cytoskeletal actin dynamics altered stretch-induced Cyr61 and Cyr61 target genes. Reciprocally, adenovirus-mediated overexpression of Cyr61 in cells cultured under static conditions increased the expression of VEGF, alpha(v)-integrin, and SM alpha-actin, as well as that of SM-1 and SM-2 isoforms, suggesting that the effects of a sustained expression of Cyr61 extend to SM specific contractile function. These effects were dependent on integrity of the actin cytoskeleton. Together, these results indicate that Cyr61 is an important determinant of the genetic reprogramming that occurs in mechanically challenged cells.
Immunopathologic and clinical features of hemolytic anemia due to cold agglutinins. (1991)

Cold agglutinins are autoantibodies capable of agglutinating red blood cells (RBC) at temperatures below 35°C. We will not consider cold-reactive allo-antibodies that sensu stricto may be subsumed under cold agglutinins as well-rather, this article deals with clonally restricted cold agglutinins
The Serologic Diagnosis of Abo Hemolytic Disease of the Newborn (1964)

Journal Article The Serologic Diagnosis of Abo Hemolytic Disease of the Newborn Get access Edmond Yunis, M.D., Edmond Yunis, M.D. With The Technical Assistance of Lila Wencler, M.T. (ASCP), and betty soderlinc, M.T. (ASCP) Department of Laboratory Medicine, University of Minnesota Medical School, Minneapolis 14, Minnesota Search for other works by this author on: Oxford Academic Google Scholar Robert Bridges, M.D. Robert Bridges, M.D. With The Technical Assistance of Lila Wencler, M.T. (ASCP), and betty soderlinc, M.T. (ASCP) Department of Laboratory Medicine, University of Minnesota Medical School, Minneapolis 14, Minnesota Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 41, Issue 1, 1 January 1964, Pages 1–7, https://doi.org/10.1093/ajcp/41.1.1 Published: 01 January 1964 Article history Received: 22 March 1963 Revision received: 21 June 1963 Accepted: 29 August 1963 Published: 01 January 1964
Antifungal activities of hop bitter resins and related compounds. Part III. Antifungal activity of 2,4-dihydroxyacylophenones and related compounds. (1985)

The antifungal activity of 2, 4-dihydroxyacylophenones and related compounds against Trichophyton spp and other fungi were investigated to determine their structure-activity relationships. The activity of these compounds was found to be closely related to the length of the acyl and alkyl substituents attached to the 1, 3-dihydroxybenzene moiety In addition, differences m activity were observed depending on the position of the alkyl substituents and on the number of substituents attached to the 1, 3-dihydroxybenzene moiety. Some compounds tested showed potent antifungal activity against Trichophyton spp. and other fungi that was more active than amphotencm B.
Nonspherical armoured bubble vibration (2017)

In this paper, we study the dynamics of cylindrical armoured bubbles excited by mechanical vibrations. A step by step transition from cylindrical to spherical shape is reported as the intensity of the vibration is increased, leading to a reduction of the bubble surface and a dissemination of the excess particles. We demonstrate through energy balance that nonspherical armoured bubbles constitute a metastable state. The vibration instills the activation energy necessary for the bubble to return to its least energetic stable state: a spherical armoured bubble. At this point, particle desorption can only be achieved through higher amplitude of excitation required to overcome capillary retention forces. Nonspherical armoured bubbles open perspectives for tailored localized particle dissemination with limited excitation power.
<title>DSP-based measuring system for temperature-compensated fiber optical oxygen sensors</title> (2002)

A new signal processing approach for fiberoptical sensors, microoptodes, is presented. All signal generation and processing is completely based on a fast, low-cost DSP (Digital Signal Processor). This enables the implementation of new features such as a simultaneous multi-frequency measurement to resolve different analytical parameters in the luminescence signal. For instance, a hybrid sensor was applied to simultaneously sense the temperature and oxygen concentration, and the temperature information was used to compensate for the temperature effect on the oxygen measurement. As a further benefit, recent improvements in indicator chemistry and fiber tip preparation also yield a luminescence signal level high enough to be detected with a common photodiode instead of a photomultiplier tube. Consequently, the combination of small detectors and highly integrated DSPs enable portable, handheld measurement devices with very little calibration requirements.
The Application of Chaotic Maps in Image-Encryption (2005)

A new encryption algorithm based on chaotic map without transcendental knowledge of orbit distributing is proposed. The algorithm reduces iterative number and makes full use of chaotic property of map. The segmentation mechanism of 2D generalized baker transformation is used to enhance the key space and security of algorithm. The security analysis of the algorithm is given. The experiments show that the algorithm has the characteristic of sensitive to initial condition, high key space and pixel distributing uniformity.
Optical microprobe for blood clot detection (2006)

One of the mayor complications during vascular surgery is the formation of blood clot. We tested an animal model and assembled a prototype device that shows the blood clot signature spectrum and its temporary growth.
Plasma Synthesis of Nitrogen-Doped Graphene Based Palladium Nanoparticles as a New Catalyst for <font>C</font>-<font>C</font> Coupling Reactions (2014)

The contents of this paper was previously published in RSC Advances and its publication has been retracted from IJN. Please contact ijn@wspc.com
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis (2008)

Ocular surface inflammation, decline in corneal sensitivity, tear film instability, changes in conjunctival epithelial MUC5AC and MUC16 mRNA expressions were thought to be important in the pathogenesis of atopic ocular surface disease.
Susceptibility Servo-Balance for Measurements on Metals of Extremely Low Resistivities (1960)

Although a great variety of methods have already been described for measuring magnetic susceptibility, the present instrument has the advantage that it makes possible measurements on weakly magnetic high-purity metals having extremely small resistivities. Most servo-balances for measuring susceptibility that have been described in the literature have been for strong paramagnetics or ferromagnetics and in none of the balances has the effect due to strong induced eddy currents been allowed for. The present instrument consists of a sensitive electrodynamic balance which is operated as a null instrument by allowing it to form part of a servomechanical network. The feedback system provides a stiffness of balance movement of 8×104 d/deg deflection. The sensitivity of this instrument is such that changes of 10−9 emu/g may be detected in the susceptibility of large metallic samples having electrical resistances less than 10−9 ohm cm.