gebhart/patrepeval huggingface dataset:
Reagent-free monitoring of multiple clinically relevant parameters in human blood plasma using a mid-infrared quantum cascade laser based sensor system (2013)

We present a semi-automated point-of-care (POC) sensor approach for the simultaneous and reagent-free determination of clinically relevant parameters in blood plasma. The portable sensor system performed direct mid-infrared (MIR) transmission measurements of blood plasma samples using a broadly tunable external-cavity quantum cascade laser source with high spectral power density. This enabled the use of a flow cell with a long path length (165 μm) which resulted in high signal-to-noise ratios and a rugged system, insensitive to clogging. Multivariate calibration models were built using well established Partial-Least-Squares (PLS) regression analysis. Selection of spectral pre-processing procedures was optimized by an automated evaluation algorithm. Several analytes, including glucose, lactate, triglycerides, cholesterol, total protein as well as albumin, were successfully quantified in routinely taken blood plasma samples from 67 critically ill patients. Although relying on a spectral range from 1030 cm(-1) to 1230 cm(-1), which is optimal for glucose and lactate but rather unusual for protein analysis, it was possible to selectively determine the albumin and total protein concentrations with sufficient accuracy for POC application.
Effect of Chloramphenicol on the DNA Synthesis of Bacteriophage ϕX174 (1971)

In bacteriophage ϕX174 infection, the net synthesis of replicative form DNA ceased between 15 and 20 min after infection. When 30 μg of chloramphenicol/ml was added, net RF synthesis, however, continued beyond the normal time and level of turn-off. Experiments with ϕX174 mutants unable to synthesize single-stranded DNA showed that a protein synthesis was required for the cessation of net RF synthesis and the protein was synthesized between 10 and 15 min after infection.
Chemo-radiotherapy: radiosensitizing nucleoside analogues (review). (1999)

The available knowledge on potential radiosensitizing nucleoside analogues with special focus on fludarabine and gemcitabine is reviewed. These analogues are prodrugs whose active triphosphate forms inhibit various enzymes involved in DNA synthesis and repair. Several properties of these analogues support their use as radiosensitizers. As repair inhibitors, they have the potential to increase the amount of residual DNA and chromosome damage after irradiation, and as DNA synthesis inhibitors, they specifically target the S-phase cell component and could thus overcome the detrimental effect of tumor clonogen repopulation during fractionated irradiation. Also, through their cytotoxic effect, these analogues could increase tumor cell loss, facilitating tumor reoxygenation, and thus obviate tumor hypoxia's inhibitory effect on radioresponse. Induction of DNA damage in all phases of the cell cycle by irradiation could create DNA sites for drug incorporation, possibly inducing an apoptotic response in cells outside of S-phase. Experimental data addressing these hypotheses are reviewed and updates on ongoing clinical trials combining fludarabine or gemcitabine and irradiation are given.
High intensity ultrasound ablation of canine prostate (1992)

Prostatic cancer is the most frequent malignant disease in man and without any satisfactory treatment of localized tumor in patients older than 70. Consequently, new therapeutic options are urgently needed to extend to unqualified patients, the potential benefits of surgery. These new options should ideally be non invasive and capable of extracorporeal and selective destruction of tissue. High intensity ultrasound is a good candidate for this new therapeutic option as it is known to induce tissue lesions in vivo by sharply focusing its beam on a specific target area within tissue [1-2].
Effect of human growth hormone and somatomedin on the recovery of sheep red blood cell receptor in peripheral T-lymphocytes. (1988)

The effect of growth hormone (GH) and somatomedin (SM) on the recovery of sheep red blood cell (SRBC) receptor in trypsinized human T-lymphocytes was studied either with the use of sera from patients with acromegaly or pituitary dwarfism or after the addition of exogenous GH, SM or thymosin to human sera. It was found that GH does not show any effect on the recovery of SRBC receptor, but it may act through the increase of SM level. It was concluded that the regulation of cellular immunity may be influenced by GH through its stimulatory action on the synthesis and release of somatomedins.
On Tracing Flicker Sources and Classification of Voltage Disturbances (2007)

Developments in measurement technology, communication and data storage have resulted in measurement systems that produce large amount of data. Together with the long existing need for characterizing the performance of the power system this has resulted in demand for automatic and efficient information-extraction methods. The objective of the research work presented in this thesis was therefore to develop new robust methods that extract additional information from voltage and current measurements in power systems. This work has contributed to two specific areas of interest.\nThe first part of the work has been the development of a measurement method that gives information how voltage flicker propagates (with respect to a monitoring point) and how to trace a flicker source. As part of this work the quantity of flicker power has been defined and integrated in a perceptionally relevant measurement method. The method has been validated by theoretical analysis, by simulations, and by two field tests (at low-voltage and at 130-kV level) with results that matched the theory. The conclusion of this part of the work is that flicker power can be used for efficient tracing of a flicker source and to determine how flicker propagates.\nThe second part of the work has been the development of a voltage disturbance classification system based on the statistical learning theory-based Support Vector Machine method. The classification system shows always high classification accuracy when training data and test data originate from the same source. High classification accuracy is also obtained when training data originate from one power network and test data from another. The classification system shows, however, lower performance when training data is synthetic and test data originate from real power networks. It was concluded that it is possible to develop a classification system based on the Support Vector Machine method with “global settings” that can be used at any location without the need to retrain. The conclusion is that the proposed classification system works well and shows sufficiently high classification accuracy when trained on data that originate from real disturbances. However, more research activities are needed in order to generate synthetic data that have statistical characteristics close enough to real disturbances to replace actual recordings as training data.
Mouse Monoclonal Antibodies Detect an Allotypic Determinant Common to Several Ruminant Species (1989)

A monoclonal antibody against goat immunoglobulins recognizes an allotypic determinant (A1) which is common to goat, sheep, cattle and water buffalo. The frequency of the corresponding gene (A') is about the same in all four species, indicating the existence of a polymorphism that remained stable over a period of about 18-20 million years.
Role of the Oxytocin Receptor Expressed in the Rostral Medullary Raphe in Thermoregulation During Cold Conditions (2015)

Recent papers have reported that oxytocin (Oxt) and the oxytocin receptor (Oxtr) may be involved in the regulation of food intake in mammals. We therefore suspected the Oxt/Oxtr system to be involved in energy homeostasis. In previous studies, we found a tendency toward obesity in Oxtr-deficient (Oxtr (-/-)) mice, as well as impaired thermoregulation when these mice were exposed to cold conditions. In the present study, we observed the expression of Oxtr in the rostral medullary raphe (RMR), the brain region known to control thermogenesis in brown adipose tissue (BAT). Through immunohistochemistry, we detected neurons expressing Oxtr and c-Fos in the RMR of mice exposed to cold conditions. Up to 40% of Oxtr-positive neurons in RMR were classified as glutamatergic neurons, as shown by immunostaining using anti-VGLUT3 antibody. In addition, mice with exclusive expression of Oxtr in the RMR were generated by injecting an AAV-Oxtr vector into the RMR region of Oxtr (-/-) mice. We confirmed the recovery of thermoregulatory ability in the manipulated mice during exposure to cold conditions. Moreover, mice with RMR-specific expression of Oxtr lost the typical morphological change in BAT observed in Oxtr (-/-) mice. Additionally, increased expression of the β3-adrenergic receptor gene, Adrb3, was observed in BAT. These results are the first to show the critical role of RMR Oxtr expression in thermoregulation during cold conditions.
A Novel Pro-Angiogenic Function for Interferon-γ–Secreting Natural Killer Cells (2014)

Our findings demonstrate a novel pro-angiogenic function for NK cells, indicating that IFN-γ-secreting NK cells can induce angiogenesis by promoting enhanced VEGF expression by macrophages.
Predominant Tubular Interleukin-18 Expression in Polyomavirus-Associated Nephropathy (2016)

Polyomavirus-associated nephropathy (PVAN) occurs in a significant percentage of renal transplant recipients, with BK virus reactivation as the main causative agent. PVAN leads to tubular damage and may result in allograft loss. In this study, we analyzed the antiviral immune response in PVAN. Transcription of the proinflammatory cytokine interleukin-18 (IL-18) was significantly higher in PVAN biopsies compared with T cell-mediated rejection (TCMR) (1.42 ± 0.20 and 0.69 ± 0.10, respectively; *P = 0.0021). Tubular expression of IL-18 was significantly increased in PVAN compared with TCMR (2.00 ± 0.24 and 1.333 ± 0.13, respectively; *P = 0.028). In contrast, in TCMR, IL-18 was expressed predominantly by CD163-positive macrophages. These data suggest that the antiviral immune response in PVAN is partly coordinated by the tubular epithelium, whereas in TCMR, this may be controlled by inflammatory cells.
PREOPERATIVE AND INTRAOPERATIVE DIFFUSION TENSOR IMAGING-BASED FIBER TRACKING IN GLIOMA SURGERY (2007)

Nimsky, Christopher M.D.; Ganslandt, Oliver M.D.; Hastreiter, Peter Ph.D.; Wang, Ruopeng Ph.D.; Benner, Thomas Ph.D.; Sorensen, A. Gregory M.D.; Fahlbusch, Rudolf M.D.
Effect of Insecticides, Predation, and Precipitation on Populations of Thrips palmi on Aubergine (Eggplant) in Guadeloupe (1990)

International audience
On the contribution of CO<sub>2</sub>fertilization to the missing biospheric sink (1995)

A gridded biospheric carbon model is used to investigate the impact of the atmospheric CO 2 increase on terrestrial carbon storage. The analysis shows that the calculated CO 2 fertilization sink is dependent not just on the mathematical formulation of the “β factor” but also on the relative controls of net primary productivity (NPP), carbon residence times, and resource availability. The modeled evolution of the biosphere for the period 1850–1990 shows an increasing lag between NPP and the heterotrophic respiration. The time evolution of the modeled biospheric sink (i.e., difference between enhanced NPP and enhanced respiration) does not match that obtained by deconvolution of the ice core CO 2 time series. Agreement between the two is reasonable for the first half of the period, but during the recent decades the deconvoluted CO 2 increase is much too fast to be explained by the CO 2 fertilization effect only. Therefore other mechanisms than CO 2 fertilization should also contribute to the missing sink. Our results suggest that about two thirds to three fourths of the 1850–1990 integrated missing sink is due to the CO 2 greening of the biosphere. The remainder may be due to the increased level of nitrogen deposition starting around 1950.
Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester. (1993)

Caffeic acid phenethyl ester (CAPE) was isolated from propolis (a product of honeybee hives) that has been used in folk medicine as a potent antiinflammatory agent. CAPE is cytotoxic to tumor and virally transformed but not to normal cells. Our main goal was to establish whether CAPE inhibits the tumor promoter (12-O-tetradecanoylphorbol-13-acetate)-induced processes associated with carcinogenesis. Topical treatment of SENCAR mice with very low doses (0.1-6.5 nmol/topical treatment) of CAPE strongly inhibits the following 12-O-tetradecanoylphorbol-13-acetate-mediated oxidative processes that are considered essential for tumor promotion: (a) polymorphonuclear leukocyte infiltration into mouse skin and ears, as quantified by myeloperoxidase activity; (b) hydrogen peroxide (H2O2) production; and (c) formation of oxidized bases in epidermal DNA, as measured by 5-hydroxymethyluracil and 8-hydroxylguanine. A 0.5-nmol dose of CAPE suppresses the oxidative burst of human polymorphonuclear leukocytes by 50%. At higher doses (1-10 mumol), CAPE inhibits edema and ornithine decarboxylase induction in CD-1 and SENCAR mice. Interestingly, we discovered that 12-O-tetradecanoylphorbol-13-acetate-induced H2O2 production in bovine lenses also is inhibited by CAPE. Cumulatively, these findings point to CAPE as being a potent chemopreventive agent, which may be useful in combating diseases with strong inflammatory and/or oxidative stress components, i.e., various types of cancer and possibly cataract development.
CRESCIMENTO E PRODUTIVIDADE DO PIMENTÃO EM DOIS SISTEMAS DE CULTIVO (2015)

This study was carried out at SIPA (Integrated System of Agroecological Production), situated in Seropédica, RJ, Brazil, in order to evaluate the effects of two cropping systems on yield and growth of sweet pepper (Capsicum annuum L.). The trial was conducted in a scheme of plots split in time, with three rep-lications, where cropping systems (conventional - CT and e no-till - NT) were assigned to the plots, while sam-pling dates were assigned to the subplots. Although values observed suggested that NT system provided a better crop growth performance in relation to CP, this superiority was not confirmed when comparing growth analysis methods. The functional method provided different values of biomass accumulation and leaf area index (LAI) of plants between two cropping systems. The highest values of LAI were 1.61 m2 m-2 and 1.31 m2 m-2, respec-tively, for NT and CT. Similar behavior was observed for accumulated plant biomass, being obtained values of 634.29 g m-2 and 511.44 g m-2, respectively, for NT and CT. In both cropping systems evaluated, three produc-tion cycles were identified, which yield peaks occurred at 58, 100 and 149 days after planting (DAP). However, yield per harvest and total yield presented no difference between the cropping systems.
A convenient synthesis of azetidine-2-thiones and azetidin-2-imines (1983)

Azetidin-2-iminium salts, which are readily available from tertiary amides, can be easily converted into the corresponding thiones or imines.
Toxic Megacolon Associated with Secondary Amyloidosis: An Unusual Complication of<i>Clostridium difficile</i>Colitis (2014)

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Association of Maternal Total Cholesterol With SGA or LGA Birth at Term: the Japan Environment and Children’s Study (2021)

Maternal TC levels in midpregnancy were associated with SGA or LGA in a Japanese cohort. It may help to predict SGA and LGA. Favorable maternal lipid profiles for fetal development must be explored.
Two Cases of Lipid-Secreting Carcinoma of the Breast: Case Reports with an Electron Microscopic Study (1988)

Two very rare cases of lipid-secreting carcinoma of the breast are reported, together with a review of the literature. Both patients were Japanese women aged 70 and 81 years, respectively. In each, a mass had been found in the breast, and radical mastectomies were performed based on a diagnosis of breast cancer at an early clinical stage. Both resected tumors were found to be solid and localized. In them, both estrogen and progesterone receptors were negative. Microscopically, hematoxylin-eosin staining showed the tumor cells to have foamy and vacuolated eosinophilic cytoplasm. Lipid staining showed the vesicles in the cytoplasm of the tumor cells to be colored a flaming red and consequently recognized as lipid droplets. An electron-microscopic study showed that the tumor cells contained various sizes of lipid droplets in the cytoplasm with no degenerative changes, and suggested that these lipid droplets were produced and stored in the tumor cells. It would appear, from the literature that lipid-secreting carcinomas have aggressive clinical courses, but neither vascular invasion nor lymph node metastasis was seen in either of our two cases.
ω phase in individual latent tracks induced by irradiation of α-titanium with megaelectronvolt fullerenes (2002)

International audience
Modal sensitivity analysis for single mode operation in large mode area fiber (2008)

Most of the current large mode area (LMA) fibers are few-moded designs using a large, low numerical aperture (N.A.) core, which promotes mode coupling between core modes and increases bending losses (coupling with claddingmodes), which is undesirable both in terms ofmode area and beamquality. Furthermore, short LMA fiber lengths and small cladding diameters are needed to minimize nonlinear effects and maximize pump absorption respectively in high-power pulsed laser systems. Although gain fiber coiling is a widely used technique to filter-out unwanted modes in LMA fibers, coupling between modes can still occur in component leads and relay fibers. In relay fiber, light coupled into higher-order modes can subsequently be lost in the coiling or continue as higher-order modes, which has the overall effect of reducing the effective transmission of the LP<sub>01</sub> mode and degrading the beam quality. However, maximum transmission of the LP<sub>01</sub> mode is often required in order to have the best possible beam quality (minimal <i>M</i><sup>2</sup>). Launching in an LMA fiber with a mode field adapter (MFA)<sup>1</sup> provides an excellent way of ensuring maximum LP<sub>01</sub> coupling, but preservation of this mode requires highmodal stability in the output fiber. Small cladding, low N.A. LMA fibers have the disadvantage of being extremely sensitive to external forces in real-life applications, which is unwanted for systems where highly sensitive mode coupling can occur. In this paper, we present a detailed experimental and theoretical analysis of mode coupling sensitivity in LMA fibers as a function of fiber parameters such as N.A., core diameter and cladding diameter. Furthermore, we present the impact of higher N.A. as a solution to increase mode stability in terms of its effect on peak power, effective mode area and coupling efficiency.
Carrier Plus: A Sensor Payload for Living With a Star Space Environment Testbed (LWS/SET) (2003)

The Defense Threat Reduction Agency (DTR4) and National Aeronautics and Space Administration (NASA) Goddard Space Flight Center are collaborating to develop the Carrier Plus sensor experiment platform as a capability of the Space Environments Testbed (SET). The Space Environment Testbed (SET) provides flight opportunities for technology experiments as part of NASA's Living With a Star (LWS) program. The Carrier Plus will provide new capability to characterize sensor technologies such as state-of-the-art visible focal plane arrays (FPAs) in a natural space radiation environment. The technical objectives include on-orbit validation of recently developed FPA technologies and performance prediction methodologies, as well as characterization of the FPA radiation response to total ionizing dose damage, displacement damage and transients. It is expected that the sensor experiment will carry 4-6 FPAs and associated radiation correlative environment monitors (CEMs) for a 2006-2007 launch. Sensor technology candidates may include n- and p-charge coupled devices (CCDs), active pixel sensors (APS), and hybrid CMOS arrays. The presentation will describe the Carrier Plus goals and objectives, as well as provide details about the architecture and design. More information on the LWS program can be found at http://lws.gsfc.nasa.gov/. Business announcements for LWS/SET and program briefings are posted at http://lws-set.gsfc.nasa.gov
3.5-cm Imaging of the Mercury North Polar Radar-Bright Features (2000)

In July 1999, the first Goldstone full-disk radar imaging of Mercury using the random-long-code (RLC) technique produced images of the north polar radar-bright features at 3.5-cm wavelength.
[Prenatal diagnosis and obstetric management of a case of Klippel-Trenaunay-Weber syndrome]. (1987)

A description is given of a case of Klippel-Trenaunay-Weber syndrome diagnosed by sonography in the 28th week of pregnancy. The ultrasound findings established in the course of pregnancy are presented. Whereas minor variants of this syndrome normally do not represent a birth hindrance, a cesarean section was indicated in the present case on the basis of the size of the deformation--especially at the hip--an in order to save the child.
Diverse Pseudomonas aeruginosa Gene Products Stimulate Respiratory (1995)

Respiratory epithelial cells play a crucial role in the inflammatory response during Pseudomonas aeruginosa infection in the lungs of patients with cystic fibrosis. In this study, we determined whether the binding of specific Pseudomonas gene products (pilin, flagellin) to their receptors on respiratory epithelial cells would result in production of the neutrophil chemoattractant IL-8. Piliated wild-type organisms, purified pili, or antibody to the pilin receptor (asialoGMi) evoked significant production of IL-8 by immortalized airway epithelial cells, whereas nonpiliated organisms were less able to bind to respiratory epithelial cells and stimulated much less IL-8 secretion (P < 0.01). A piliated, nonflagellated strain was also associated with decreased binding and a diminished level of IL-8 production when compared to wild-type organisms. Isogenic, nonadherent rpoN mutants, lacking pilin and flagellin, did not bind or elicit an IL-8 response. In addition, the IL-8 response was four-fold higher in a cystic fibrosis cell line compared with its corrected cell line. The Pseudomonas autoinducer, an exoproduct secreted during chronic infection, was found to stimulate IL-8 in a dose-dependent manner. P. aeruginosa adhesins, which are necessary for initial infection, directly stimulate IL-8 production by respiratory epithelial cells and therefore play a major role in the pathogenesis of Pseudomonas infection in patients with cystic fibrosis. The inflammatory response is subsequently perpetuated by Pseudomonas autoinducer