gebhart/patrepeval huggingface dataset:
Avoiding trickle‐down recompilation in the Mary2 implementation (1984)

Abstract Programming languages which support separate but not independent compilation are prone to a problem called trickle‐down recompilation. These languages, which include Ada, Modula and others as well as Mary2, 1 permit a compilation unit to refer at compile time to objects declared in another, imported, compilation unit. When the exporting compilation unit is recompiled for any reason, its exported interface may change, and so the importing compilation units which are the clients of that interface must be recompiled. These recompilations in turn force others, and so on Many recompilations are in fact innocuous, in that they may change the run‐time behaviour of the recompiled unit but do not alter the exported interface. This paper describes the implementation of that portion of the Mary2 language system which performs just those recompilations actually necessary and avoids redundant recompilations. The methods described are applicable to the implementation of any other language which enforces version control across compilations.
Antithrombotic Drugs: Pharmacology and Implications for Dental Practice (2013)

Appropriate preoperative assessment of the dental patient should always include an analysis of the patient's medications. This article reviews the actions and indications for the various categories of antithrombotic medications and considers actual risks for postoperative bleeding and potential interactions with drugs the dental provider might administer or prescribe.
Myths of Discovery and Settler Identity: Probing the 'first' Crossing of the Blue Mountains after 200 years (2014)

While it is tempting to regard maps as re-creations of the landscapes they depict, at root they are aids for navigation. As a lifelong admirer of the charts Myles Dunphy created for fellow bushwalkers of the Blue Mountains, peppered with advice and warnings ('extremely steep', 'bad drinking water'), I have come to accept that departures from verisimilitude are admissible, and often necessary, if the map is to truly serve the traveller. Something analogous applies to works of history, for a history is not a re-creation of the past, but a map for thinking about it. In contrast to the planar two-dimensionality of the cartographer's map, the chart created by the historian must incorporate temporal as well as spatial phenomena. This makes for a map that is more irregular, more idiosyncratic, and more layered than any that a cartographer might design. My purpose here is to map a few of the many ripples caused by a journey through the Blue Mountains of New South Wales in 1813. This journey, this 'first' crossing as it became known erroneously, has been the subject of innumerable iterations, and for a long period served as a locational motif for settler society. So it is a journey through a journey on which we now embark.
Evaluation of Factors Influencing Antibody Reduction for Development of Antibody Drug Conjugates (2017)

Optimized site-specific conjugation can provide better process control and reproducibility for the development of disulfide-based ADCs.
Upper Tibial Osteotomy (1984)

Arthritis of the knee usually produces a change in the coronal plane of the normal femorotibial axial alignment. This change occurs if the arthritis is mostly unicompartmental. Most unicompartmental degenerative arthritis involves the medial compartment, producing a varus deformity. In rheumatoid patients, however, a valgus deformity is commonly produced. For at least the last 25 years, upper tibial osteotomy has been used to correct this malalignment. The rationale is to unload the more involved compartment and transfer the load to the less involved side. While the vast majority of upper tibial osteotomies are done for degenerative arthritis, the procedure is occasionally indicated in the inactive stage of rheumatoid arthritis. A study of 213 knees with a 16-year follow-up period showed that, even before total knee arthroplasty (TKA) was available as an alternative, 61% of the knees were satisfactory after ten years. With the additional choice of either unicompartmental or bicompartmental TKA during the past decade, the selection for upper tibial osteotomy can be more specific. The need to overcorrect to about 10 degrees of valgus in a varus knee has been established. In addition, technical aspects have been improved. With the more specific selection of patients and improvement in the exactness of the technique, an even higher incidence of long-term excellent and good results can be anticipated. Finally, it has been clearly demonstrated that when the bone and articular cartilage are relieved from the overloaded state, the cartilage will regenerate. Thus, upper tibial osteotomy not only relieves pain and improves function but also allows for healing of the articular cartilage.
Preparation and Evaluation of Topical Microemulsion System Containing Metronidazole for Remission in Rosacea (2012)

The aim of this study was to prepare a topical water-in-oil type microemulsion containing metronidazole and to compare its effectiveness with a commercial gel product in the treatment of rosacea. A pseudo-ternary phase diagram (K(m)=2:1) was constructed using lecithin/butanol/isopropyl myristate/water. The microemulsion was chosen from the microemulsion region in the phase diagram. The formulation was a water-in-oil type microemulsion (droplet size: 11.6 nm, viscosity: 457.3 mPa·s, conductivity: 1.5 µs/cm, turbidity: 6.89 NTU) and the addition of the metronidazole did not alter the properties of the system. The release experiment showed that the release rate of metronidazole from the commercial gel product was higher than that of the microemulsion. Stability experiments showed that the metronidazole microemulsion remained stable for at least 6 months; none of the characteristic properties of the microemulsion had changed, the system retained its clarity and there was no sign that crystallization of metronidazole has occurred. Microemulsion was compared to a gel product in a randomized, double-blind, baseline-controlled, split-face clinical trial for the treatment of patients. After the 6-week treatment period there was a statistically significant difference in reduction of the main symptoms of rosacea. Of the patients treated with the microemulsion, 17% experienced complete relief from inflammatory lesions, and 50% from erythema. The microemulsion resulted in complete relief in 38% of the patients with telangiectasia while the commercial product did not provide any relief of telangiectasia symptoms. In conclusion, the microemulsion containing metronidazole was found to be more effective in reducing the symptoms of rosacea compared to the commercial gel product.
Feature-based recognition of triangulated arbitrary surfaces (2002)

A procedure is presented for recognizing an object from its range data. A set of object surface data points are segmented into triangular patches using a small number of knot points. These knot points are placed by the local adjustment technique. For the resulting triangulated surface model, high-level edge lines are extracted using unit normal vectors of the triangular patches. This set of high-level primitives is used to construct a graph structure for each object. Experimental results are presented for a set of objects with salient features.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Study on Performance of Fiber Reinforced Concrete Composite Beam Structure (2016)

FRP (fiber reinforced polymer material) having a high specific strength and specific modulus, good corrosion resistance and other advantages. FRP materials in civil engineering industry has been more and more popular, and gradually become a hot issue in the world. In order to take full advantage of a variety of materials and overcome the problems in the FRP structure, this paper mainly studies the composite structure of FRP and traditional materials, namely FRP-concrete composite beam structure. The mechanical parameters of FRP (mainly including CFRP and GFRP) were selected. And the stress -strain diagram of FRP materials are drawn. Through tensile tests on FRP (including CFRP and GFRP), FRP was found to belong to brittle materials. As well as the mechanical properties of FRP materials, the ultimate load analysis, the decision to use CFRP as a composite beam structural stiffness of the research materials. When considering concrete shrinkage, creep, temperature difference effect, the stiffness of composite beam meets the requirement. The deflection of FRP- concrete composite beam is verified by mechanical formula. The change of the concrete stiffness will affect the change of the structural stiffness of the FRP- concrete composite beam. As well as through an example, it is found that the concrete shrinkage and temperature can affect the change of the stiffness of the composite structure.
A New Spatial-Temporal Correlation Model for MIMO Channel (2006)

Current researches on multiple-input multiple-output (MIMO) channel treat it as a kind of Gaussian channel. Without considering the spatial-temporal correlation, considerable deviation exists in output. This paper presents a novel spatial-temporal correlation model (STCM) for MIMO channel modeling. We adopt a correlation matrix to model the spatial correlation at the base and use wave superposition to capture the spatial-temporal correlations at the mobile. Result of simulation shows that the H matrices can construct directly with accurate parameter correlation statistics and spatial-temporal channel correlation may be attained. STCM model minimizes the deviation of conventional model in virtue of the comprehensive consideration of spatial-temporal correlation
Special peptidyl-tRNA molecules can promote translational frameshifting without slippage. (1994)

Recently we described an unusual programmed +1 frameshift event in yeast retrotransposon Ty3. Frameshifting depends on the presence of peptidyl-tRNA(AlaCGC) on the GCG codon in the ribosomal P site and on a translational pause stimulated by the slowly decoded AGU codon. Frameshifting occurs on the sequence GCG-AGU-U by out-of-frame binding of a valyl-tRNA to GUU without slippage of peptidyl-tRNA(AlaCGC). This mechanism challenges the conventional understanding that frameshift efficiency must correlate with the ability of mRNA-bound tRNA to slip between cognate or near-cognate codons. Though frameshifting does not require slippery tRNAs, it does require special peptidyl-tRNAs. We show that overproducing a second isoacceptor whose anticodon had been changed to CGC eliminated frameshifting; peptidyl-tRNA(AlaCGC) must have a special capacity to induce +1 frameshifting in the adjacent ribosomal A site. In order to identify other special peptidyl-tRNAs, we tested the ability of each of the other 63 codons to replace GCG in the P site. We found no correlation between the ability to stimulate +1 frameshifting and the ability of the cognate tRNA to slip on the mRNA--several codons predicted to slip efficiently do not stimulate frameshifting, while several predicted not to slip do stimulate frameshifting. By inducing a severe translational pause, we identified eight tRNAs capable of inducing measurable +1 frameshifting, only four of which are predicted to slip on the mRNA. We conclude that in Saccharomyces cerevisiae, special peptidyl-tRNAs can induce frameshifting dependent on some characteristic(s) other than the ability to slip on the mRNA.
450 meV hole localization in GaSb/GaAs quantum dots (2003)

The electronic properties of self-organized GaSb quantum dots (QDs) embedded in GaAs n+p diodes were investigated by capacitance–voltage and deep level transient spectroscopy. The localization energy of the hole ground state is 450 meV. State filling lowers the activation energy to 150 meV for completely charged QDs containing 15 holes. The hole retention time at room temperature for a single hole per QD is extrapolated to be in the microsecond range, about five orders of magnitude longer than in In(Ga)As/GaAs QDs. Hence, we consider GaSb/GaAs to be a suitable material system for future QD memory applications which require long storage times.
The Human System (2000)

This chapter contains section titled: The Fishers A Typology of Fishers A Typology of Fishing Methods Beyond the Fishers The Post-Harvest Sector and Consumers Marketing and Distribution Processing Markets Consumers Fishing Households and Communities The Socioeconomic Environment Summary
Effect of delay in processing on lysis-centrifugation blood culture results from marrow transplant patients (1989)

The effect of delay in processing on results of lysis-centrifugation (LC; Isolator) blood cultures was assessed in 4,577 paired blood specimens. Blood specimens were obtained at all hours from 384 febrile marrow transplant patients with indwelling venous catheters and were processed by the LC technique and by a conventional two-bottle method. Most patients (84%) were receiving broad-spectrum antibiotics at the time of blood culture. Specimens were delivered to the laboratory, where Isolator tubes were held at 35 degrees C and processed in batches between 0700 and 1730 h daily. This procedure resulted in a delay beyond the manufacturer-suggested processing time of less than 8 h for 1,853 (42%) of the LC cultures. There was no overall difference in the recovery of organisms present in LC cultures processed after being held for 8 to 24 h compared with the conventional two-bottle method. LC methodology had shorter time to detection than the conventional method for detection of Candida spp. and Pseudomonas spp. (P less than 0.05). However, time to detection for Streptococcus spp. and members of the family Enterobacteriaceae, responsible for 16.3% of total isolates, was prolonged significantly by delay in processing when compared with the conventional two-bottle method (P less than 0.01). Results of this study support the recommendation of the manufacturer for processing of Isolator tubes within 8 h or less. Although one can safely delay processing beyond 8 h in terms of total recovery of organisms, such delays were associated with longer time to detection for certain important potentially pathogenic organisms which accounted for a sizeable proportion of blood culture isolates from marrow transplant patients.
A user's insight into radiated emission testing with GTEM cells (2002)

The effectiveness and limitations of the GTEM cell as a tool for measuring radiated emissions from computer systems is discussed. A description of the GTEM cell, the theory, and operation are detailed. Comparison to existing tools, procurement, and GTEM methodology/procedures are discussed. GTEM versus open-air test site (OATS) test data comparisons are given, and GTEM cell error sources are detailed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Variable-Rate, Weakly- and Strongly-Universal Source Coding Subject to a Fidelity Constraint. (1977)

The goal of universal source coding is to find codes which are efficient for sources with unknown or incompletely specified probability distributions; this is equivalent to finding codes which are efficient for a collection of sources.Previous work in universal variable-rate source coding subject to a fidelity constraint has assumed a prior probability measure on a collection of stationary ergodic sources.It is then shown that there is a single code which gives an average distortion D at an optimum rate, R-(D), for most sources 9 in the collection.This code 9
Potency of Adrenaline and Noradrenaline for <i>β</i>-Adrenergic Proton Extrusion From Red Cells of Rainbow Trout, <i>Salmo Gairdneri</i> (1988)

The red cell adrenoceptor affinity for the unspecific agonists adrenaline and noradrenaline and the specific beta-agonist isoprenaline was studied in vitro on whole blood of rainbow trout, Salmo gairdneri at 15 degrees C. The erythrocytic adrenoceptors could be pharmacologically characterized as beta-receptors of the 'noradrenaline'-type (beta 1-type), with an order of potency of isoprenaline greater than noradrenaline much greater than adrenaline. The adrenoceptor affinities, expressed as agonist concentrations for 50% response (EC50), were 1.3 X 10(-8) and 7.6 X 10(-7) mol l-1 for noradrenaline and adrenaline, respectively. Winter fish showed a red cell adrenergic response identical to that of summer-acclimated fish. It is concluded that most red cell beta-adrenergic responses in vivo are exclusively elicited by noradrenaline.
A General Brokering Architecture Layer and its Application to Video on-Demand over the Internet (2007)

GOAL -General brOkering Architecture Layer- is a service architecture which allows the development and the management of highly flexible, scalable and self-configurable distributed and service-oriented applications over the Internet. GOAL centres on a design pattern which decouples the design of service functionalities from the distribution concerns. A service wrapper is specifically responsible of the distribution aspects. The wrapper is weaved at runtime to its corresponding service by a dynamic proxy object. GOAL makes it possible to augment, in a transparent way, the behaviour of a software object in order to permit it to be remotely accessible. Current implementation of GOAL depends on Sun Microsystems’ Jini as the brokering/middleware layer. The paper describes GOAL and demonstrates its practical use through the design and implementation of a Video on-Demand system. Java Media Framework is used for pumping multimedia data at the transmitter side and for rendering purposes at the receiver side, RTP/RTCP protocols are used for multimedia streaming. Povzetek: Predstavljen je GOAL ‐ arhitektura za napredne spletne aplikacije, npr. video na zahtevo.
Synthesis, characterization, and antitumor evaluation of the albumin–SN38 conjugate (2012)

7-Ethyl-10-hydroxycamptothecin (SN38), the active metabolite of irinotecan, exerts a 100-fold to 1000-fold higher effect than irinotecan itself against several tumor cell lines. However, the water insolubility of SN38 has prevented its direct use as an antitumor drug in the clinic. To improve the water solubility and antitumor efficacy, SN38 was covalently attached to the only free sulfhydryl at cysteine-34 on the BSA site specifically through a thiol-binding linker to form a prodrug BSA-SN38 conjugate (BSA : SN38=1 : 1). The water solubility of this conjugate was similar to albumin using the current method. Also, SN38 loading in this conjugate became controllable. Size-exclusion chromatography purification and UV characterization of the SDS-PAGE electrophoresis product were carried out. Then, an MTT assay was carried out to test the antitumor effect of this conjugate on five colon cancer cell lines in vitro. The 72 h IC50 values of the BSA-SN38 conjugate ranged from 1.5 to 6.1 μmol/l. A colorectal peritoneal carcinomatosis model in mice was established to determine the intraperitoneal chemotherapy effect of the BSA-SN38 conjugate. The BSA-SN38 conjugate at an SN38 equivalent dose of 10 mg/kg/day was administrated every 4 days. Eighteen days after manipulation, the mice were euthanized and the tumors in the abdominal cavity were collected and weighed. Tumors in the BSA-SN38 conjugate treatment group (m=0.21 ± 0.15 g) were found to be significantly (P=5) lighter than those in the NS control group (m=4.74±0.73 g). The results indicated that this water-soluble BSA-SN38 conjugate exerted a strong antitumor effect on colorectal carcinoma.
Aerostatic load on the deck of cable-stayed bridge in erection stage under skew wind (2016)

In conventional buffeting theory, it is assumed that the aerostatic coefficients along a bridge deck follow the strip assumption. The validity of this assumption is suspect for a cable-stayed bridge in the construction stages, due to the effect of significant aerodynamic interference from the pylon. This situation may be aggravated in skew winds. Therefore, the most adverse buffeting usually occurs when the wind is not normal to bridge axis, which indicates the invalidity of the traditional "cosine rule". In order to refine the studies of static wind load on the deck of cable-stayed bridge under skew wind during its most adverse construction stage, a full bridge 'aero-stiff' model technique was used to identify the aerostatic loads on each deck segment, in smooth oncoming flow, with various yaw angles. The results show that the shelter effect of the pylon may not be ignored, and can amplify the aerostatic loading on the bridge deck under skew winds (<TEX>$10^{\circ}-30^{\circ}$</TEX>) with certain wind attack angles, and consequently results in the "cosine rule" becoming invalid for the buffeting estimation of cable-stayed bridge during erection for these wind directions.
Abnormal Pressure Study in the Malay and Penyu Basins: A Regional Understanding: ABSTRACT (1994)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Horizontal visibility graphs: Exact results for random time series (2009)

The visibility algorithm has been recently introduced as a mapping between time series and complex networks. This procedure allows us to apply methods of complex network theory for characterizing time series. In this work we present the horizontal visibility algorithm, a geometrically simpler and analytically solvable version of our former algorithm, focusing on the mapping of random series (series of independent identically distributed random variables). After presenting some properties of the algorithm, we present exact results on the topological properties of graphs associated with random series, namely, the degree distribution, the clustering coefficient, and the mean path length. We show that the horizontal visibility algorithm stands as a simple method to discriminate randomness in time series since any random series maps to a graph with an exponential degree distribution of the shape P(k)=(1/3)(2/3)(k-2), independent of the probability distribution from which the series was generated. Accordingly, visibility graphs with other P(k) are related to nonrandom series. Numerical simulations confirm the accuracy of the theorems for finite series. In a second part, we show that the method is able to distinguish chaotic series from independent and identically distributed (i.i.d.) theory, studying the following situations: (i) noise-free low-dimensional chaotic series, (ii) low-dimensional noisy chaotic series, even in the presence of large amounts of noise, and (iii) high-dimensional chaotic series (coupled map lattice), without needs for additional techniques such as surrogate data or noise reduction methods. Finally, heuristic arguments are given to explain the topological properties of chaotic series, and several sequences that are conjectured to be random are analyzed.