gebhart/patrepeval huggingface dataset:
Denise: A Virtual Patient (2015)

Abstract Introduction The virtual patient (VP) program “Denise” was designed to present a clinical scenario that may not be encountered during a short psychiatry clinical rotation in medical school or an advanced nurse or physician assistant program. This interactive VP scenario allows the trainee to elicit history from the VP presenting for an initial psychiatric evaluation by asking questions to cover a psychiatric interview and mental status exam. As undergraduate medical training is increasingly distributed at distant sites and campuses, the VP offers the opportunity for deliberate, standardized psychiatric interview practice with immediate feedback to the learner anywhere, anytime. Methods Our team from the Medical College of Georgia at Georgia Regents University Department of Psychiatry and Health Behavior and the University of Florida's Department of Computer and Information Science and Engineering created the web-based VP. Students interact with the VP Denise using a web-browser-based VP system, Virtual People Factory (VPF), developed at coauthor Lok's research lab. The scenario was tested and enhanced prior to submission. Results Student satisfaction with the Denise VP was measured with a nine item survey on a 5-point Likert scale, items being labeled as Poor, Fair, Average, Good, and Excellent. The VP satisfaction survey is attached, and users are welcome to use it in its current format or customize it for their needs. Satisfaction with each item varied; 58% of students rated the VP simulating real life as average, good, or excellent, and 93% of students rated the VP helping to formulate questions about mood symptoms as average, good, or excellent. Discussion The VP version presented here has been significantly enhanced by the addition of over 800 suggestions made by study participants in the process of interacting with the VP. VP responses to these suggestions were created as well. In addition, to respond to students' comments about the VP interaction, we added a feature that gives the user response options to choose from in case the VP requires question clarification.
On the Rocks of the Essex Drift (1887)

The rocks of the drift in Essex are of such great variety that it is very difficult to get a really representative collection; but I have selected some two hundred specimens out of a much larger number, and these, I think, may fairly be called representative, at any rate of the rocks in the western and north-western parts of Essex. Some of these are chips from large boulders, others are rolled pebbles. I have gathered them from the surface of the land within a radius of about four miles from Felstead, taking them chiefly from the open fields, the lanes, ditches, and bye-roads, and avoiding the main roads for obvious reasons, although no imported road-metal is used in the immediate neighbourhood. A considerable number have been taken out of the Boulder-clay, and some few from the gravel-beds which underlie it. The village of Felstead stands upon high ground overlooking the valley of the Chelmer, about six miles to the north-west of Braintree and just off the highroad between Braintree and Dunmow. The general appearance of this part of Essex is that of a tableland which has been carved out into valleys, with gently sloping rounded hills. On the slopes of these hills there are at all levels, even to the very tops, beds of loamy gravel, alternating with a considerable thickness of stiff yellow loam in some parts, and in others with chalky Boulderclay, patches of which lie on the tops of the hills and along the upper slopes, sometimes
Role of LPA<sub>4</sub>/p2y9/GPR23 in Negative Regulation of Cell Motility (2008)

Lysophosphatidic acid (LPA) is a ligand of multiple G protein-coupled receptors. The LPA(1-3) receptors are members of the endothelial cell differentiation gene (Edg) family. LPA(4)/p2y9/GPR23, a member of the purinergic receptor family, and recently identified LPA(5)/GPR92 and p2y5 are structurally distant from the canonical Edg LPA receptors. Here we report targeted disruption of lpa(4) in mice. Although LPA(4)-deficient mice displayed no apparent abnormalities, LPA(4)-deficient mouse embryonic fibroblasts (MEFs) were hypersensitive to LPA-induced cell migration. Consistent with negative modulation of the phosphatidylinositol 3 kinase pathway by LPA(4), LPA(4) deficiency potentiated Akt and Rac but decreased Rho activation induced by LPA. Reconstitution of LPA(4) converted LPA(4)-negative cells into a less motile phenotype. In support of the biological relevance of these observations, ectopic expression of LPA(4) strongly inhibited migration and invasion of human cancer cells. When coexpressed with LPA(1) in B103 neuroblastoma cells devoid of endogenous LPA receptors, LPA(4) attenuated LPA(1)-driven migration and invasion, indicating functional antagonism between the two subtypes of LPA receptors. These results provide genetic and biochemical evidence that LPA(4) is a suppressor of LPA-dependent cell migration and invasion in contrast to the motility-stimulating Edg LPA receptors.
Pentamethylcyclopentadienyl—Ruthenium Catalysts for Regio‐ and Enantioselective Allylation of Nucleophiles (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Copper(<scp>I</scp>) (Pseudo)Halide Complexes with Neocuproine and Aminomethylphosphines Derived from Morpholine and Thiomorpholine – <i>In Vitro</i> Cytotoxic and Antimicrobial Activity and the Interactions with <scp>DNA</scp> and Serum Albumins (2013)

Herein, a series of CuI or CuNCS complexes with neocuproine (2,9-dimethyl-1,10-phenanthroline: dmp) and two tris(aminomethyl)phosphines derived from morpholine (P(CH2 N(CH2 CH2 )2 O)3 ) or thiomorpholine (P(CH2 N(CH2 CH2 )2 S)3 ) were tested as cytotoxic agents in vitro towards mouse colon carcinoma (CT26) and human lung adenocarcinoma (A549). The studies showed that the complexes exhibit potential antitumor properties, displayed by IC50 values below 10 μm towards the tested cell lines, in the case of 4-h incubation time with the examined compounds. Moreover, a high antimicrobial activity of all the complexes was observed against Staphylococcus aureus and Candida albicans with minimal inhibitory concentrations equal to 1-2 μg/mL. To gain insight into the molecular mechanism of biological activity of the complexes, we investigated also their interactions with plasmid DNA (pUC18) and the human and bovine serum albumins. Gel electrophoresis experiments demonstrated that all the compounds were comparably efficient in DNA degradation process; however, luminescence quenching showed surprising dependence on the interactions strength of the used compounds with the albumins. Apart from exceptionally effective [CuI(dmp)P(CH2 N(CH2 CH2 )2 O)3 ], the complexes with P(CH2 N(CH2 CH2 )2 O)3 quenched more strongly luminescence of bovine serum albumin, while the complexes with P(CH2 N(CH2 CH2 )2 S)3 were more active in the quenching of human serum albumin luminescence.
Antimicrobial activity of some thiol-containing heterocycles. (1983)

The minimum inhibitory concentration values for a group of synthesized heterocyclic systems were determined for Gram-positive and Gram-negative bacteria, yeast and fungi. The active compounds were screened further against a number of yeast and yeast-like organisms and Gram-positive bacteria. The effect of two of these compounds on growth and mutagenicity was also tested. An attempt was made to correlate the structure of the compounds with their antimicrobial activity.
New modeling approach of on‐chip interconnects for RF integrated circuits in CMOS technology (2003)

New analytical approximation for the frequency‐dependent impedance matrix components of symmetric VLSI interconnect on lossy silicon substrate are derived. The results have been obtained by using an approximate quasi‐magnetostatic analysis of symmetric coupled microstrip on‐chip interconnects on silicon. We assume that the magnetostatic field meets the boundary conditions of a single isolated infinite line; therefore, the boundary conditions for the conductors in the structure are approximately satisfied. The derivation is based on the approximate solution of quasi‐magnetostatic equations in the structure (dielectric and silicon semi‐space), and takes into account the substrate skin‐effect. Comparisons with published data from circuit modeling or full‐wave numerical analyses are presented to validate the inductance and resistance expressions derived for symmetric coupled VLSI interconnects. The analytical characterization presented in this paper is well situated for inclusion into CAD codes in the design of RF and mixed‐signal integrated circuits on silicon.
ChemInform Abstract: Solid‐State NMR Study Using Trimethylphosphine as a Probe of Acid Sites in Normal and Dealuminated Zeolite Y. (1989)

Abstract The 31 P MAS NMR study shows that Me 3 P is an effective probe molecule for studying both Bronsted and Lewis acid sites in acidic Y‐type zeolites.
A pH-dependent reversible conformational transition of the human transferrin receptor leads to self-association. (1988)

Human transferrin receptor (tfR) is a covalent homodimer of 90-kDa transmembrane subunits, which transits an endocytotic pathway involving exposure to low pH. Digestion of purified tfR at neutral pH generates a soluble noncovalent dimer of 70-kDa fragment subunits containing 95% of the extracellular tfR sequence, including the transferrin binding sites. Below pH 6, the 70-kDa fragment undergoes a conformational transition, which causes reversible association of the dimers in solution. Transferrin binding prevents both the conformational transition and the self-association. We suggest that tfR clustering in acidic compartments results from self-association due to a conformational change that is sensitive to transferrin binding. This and other observations support a concentration mechanism based on interactions between ectodomains in intracellular lumina.
Complex repetitive discharges: Cause or effect of neurogenic muscle hypertrophy? (1999)

We report a patient with adult-onset spinal muscular atrophy (SMA) of the scapulohumeral type with neurogenic muscle hypertrophy (NMH) in markedly weakened biceps muscles in association with continuous complex repetitive discharges (CRDs). This is an apparently unique case due to the bilaterality of the NMH associated with CRDs as well as the well-circumscribed symmetric upper extremity distribution of the hypertrophy. The possible mechanisms of NMH in association with spontaneous motor activity are discussed.
Wave driven N2–Ar discharge. I. Self-consistent theoretical model (2002)

A theoretical model for a low pressure surface wave driven N2–Ar discharge accounting in a self-consistent way for electron and heavy particle kinetics, gas thermal balance, and wave electrodynamics is developed. The inhomogeneous wave power transfer along the discharge and the concentrations of active species as a function of the spatial position and mixture composition are investigated. N2+ are the dominant ions over a wide range of Ar percentages in the mixture due to the contributions of charge transfer processes between Ar+ and N2 and an effective associative ionization from N2(A 3Σu+). Dissociative recombination of N2+ with electrons provides an increase in the dissociation degree of nitrogen molecules at high Ar fractional concentration.
Genetic and Molecular Analysis of Circadian Rhythms in <i>N</i><i>eurospora</i> (2001)

Over the course of the past 40 years Neurospora has become a well-known and uniquely tractable model system for the analysis of the molecular basis of eukaryotic circadian oscillatory systems. Molecular bases for the period length and sustainability of the rhythm, light, and temperature resetting of the circadian system and for gating of light input and light effects are becoming understood, and Neurospora promises to be a suitable system for examining the role of coupled feedback loops in the clock. Many of these insights have shown or foreshadow direct parallels in mammalian systems, including the mechanism of light entrainment, the involvement of PAS:PAS heterodimers as transcriptional activators in essential clock-associated feedback loops, and dual role of FRQ in the loop as an activator and a repressor; similarities extend to the primary sequence level in at least one case, that of WC-1 and BMAL1. Work on circadian output in Neurospora has identified more than a dozen regulated genes and has been at the forefront of studies aimed at understanding clock control of gene expression.
The global dimensionality of face space (2002)

A low-dimensional representation of sensory signals is the key to solving many of the computational problems encountered in high-level vision. Principal component analysis (PCA) has been used in the past to derive such compact representations for the object class of human faces. Here, with an interpretation of PCA as a probabilistic model, we employ two objective criteria to study its generalization properties in the context of large frontal-pose face databases. We find that the eigenfaces, the eigenspectrum, and the generalization depend strongly on the ensemble composition and size, with statistics for populations as large as 5500, still not stationary. Further, the assumption of mirror symmetry of the ensemble improves the quality of the results substantially in the low-statistics regime, and is also essential in the high-statistics regime. We employ a perceptual criterion and argue that, even with large statistics, the dimensionality of the PCA subspace necessary for adequate representation of the identity information in relatively tightly cropped faces is in the 400-700 range, and we show that a dimensionality of 200 is inadequate. Finally, we discuss some of the shortcomings of PCA and suggest possible solutions.
CARBONIUM PERCHLORATES IN CHLOROFORM SOLUTION (1961)

not available
A Study on the Equations for Load Carrying Capacities of Concrete Filled tubular Square Column-to-Beam Connections with Combined Cross Diaphragm and Sleeves (2005)

The objective of this study is to clarify the structural features of members consisting of a connection, as part of the previous study on the CFT column-to-beam tensile connection with a combined cross diaphragm. This connection has the following merits: it evenly distributes the stress on the beam flange and the diaphragm and reduces the stress concentration by improving the stress transfer route and restraining the abrupt deformation of the diaphragm. Finite element analysis was performed to find out the stress transfer through the sleeve, which is an important member of the connection with a combined cross diaphragm. The length and thickness of the sleeve were used as variables for the analysis. The analysis results showed that the length and thickness of the sleeve did not influence the capacity of the connection and played the role of a medium for the transfer of the stress from the diaphragm to the filled concrete. It was proposed that the appropriate length of the sleeve have the same value as the diameter of the sleeve and that the appropriate ratio of the sleeve diameter to the sleeve thickness be 20. Two equations for the evaluation of the load carrying the capacity of the connection were also proposed through the modification of the evaluation equation suggested in the previous study.
Hospital physician awareness about management of antibiotic-resistant gram-negative (ARGN) infections (2015)

New antibiotics have been introduced over the years to overcome drug resistance, but even these antibiotics have lost their efficacy against important Gram-negative bacteria with resistance to these drugs increasing rapidly across Europe and adjacent regions. We surveyed 800 hospital-based physicians in 4 European countries and Russia to assess their level of ARGN awareness and perceived ability to manage this growing and serious problem.
Random number generation using field programmable analog array implementation of logistic map (2013)

Random number generators are cryptographic components that generate unpredictable, independent and identically distributed bits. We studied 1D chaotic logistic map in the context of random number generation. Nonlinear dynamics of the logistic map, its statistical and spectral features are studied using numerical simulations. Logistic map based random number generator is implemented on a discrete time operating field programmable analog array chip. We evaluated the random number generation performance of our design using NIST 800.22 statistical tests.
Photochemical Formation of Bicyclo[3.1.0]hex-2-ene and 3-Vinylcyclobutene from 1,3-Cyclohexadiene<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical Formation of Bicyclo[3.1.0]hex-2-ene and 3-Vinylcyclobutene from 1,3-Cyclohexadiene1Jerrold Meinwald and Paul H. MazzocchiCite this: J. Am. Chem. Soc. 1966, 88, 12, 2850–2851Publication Date (Print):June 1, 1966Publication History Published online1 May 2002Published inissue 1 June 1966https://pubs.acs.org/doi/10.1021/ja00964a042https://doi.org/10.1021/ja00964a042research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Novel Method To Analyze Betaine in Chicken Liver:  Effect of Dietary Betaine and Choline Supplementation on the Hepatic Betaine Concentration in Broiler Chicks (2001)

Betaine was measured from liver tissue by a high-performance liquid chromatographic (HPLC) method developed for this study. The method involves homogenization of liver in acetate buffer at pH 6 and precipitation of protein with trichloroacetic acid, which was removed by diethyl ether extraction. Betaine was separated using a cation exchange column in Ca(2+) form and detected with a refractive index detector. This method also allows the determination of S-adenosylmethionine (S-AM) from the same liver extract but with different HPLC conditions. Broiler chicks were fed with experimental diets supplemented with four different doses of betaine or choline ranging from 0 to 5 mol equiv. After a 3 week feeding period, the livers were analyzed for betaine and S-AM. Dietary betaine was twice as efficient in increasing the hepatic betaine concentration as dietary choline. The hepatic S-AM concentrations were similar in all dietary treatments.
Critical path analysis for the execution of parallel and distributed programs (2003)

The authors present the design, implementation, and testing of the critical path analysis technique using the IPS performance measurement tool for parallel and distributed programs. They create a precedence graph of a program's activities (program activity graph) with the data collected during the execution of a program. The critical path, the longest path in the program activity graph, represents the sequence of the program activities that take the longest time to execute. Various algorithms are developed to track the critical path from this graph. The events in this path are associated with the entities in the source program, and the statistical results are displayed on the basis of the hierarchical structure of the IPS. The test results from the measurement of sample programs show that the knowledge of the critical path in a program's execution helps users identify performance problems and better understand the behavior of a program.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
TU-E-201C-01: Ultrasound Elasticity Evaluation of Vocal Cord Function (2010)

Purpose: Treatment of oral and oropharyngeal cancer often injures the vocal cords affecting the patient's speech and quality of life. Current clinical speech evaluations are hampered by their subjectivity. The purpose of this study is to develop a quantitative ultrasound technique to accurately capture vocal cord function. Method and Materials: We adapted an elastography technique to measure the stiffness of the vocal cord. Changes in vocal cord stiffness correlate with pathological phenomena and are indicators of vocal cord injury. For this initial investigation, 12 healthy volunteers were scanned using a clinical ultrasound scanner with a 14 MHz linear array transducer. Each volunteer was asked to pronounce four vowels: “e,” “o,” “i,” and “a.” 120 consecutive frames of radio-frequency data were acquired in 5-second intervals while the volunteers pronounced each vowel. A 4 mm (110 sample points) by 6 mm (40 lines) region of interest of the true fords was analyzed. The displacement of two consecutive frames was computed with the multilevel hybrid 2D cross-correlation algorithm. The strain (stiffness) was obtained by slope estimation of the displacement using a least-square calculation. The accumulated displacement and strain were integrated over time and compensated using boundary conditions assuming the vocal cord should return to its initial position. To ensure reproducibility measurements were repeated 2 to 6 times. Results: Each vowel exhibited a distinctive displacement and strain curve; however, particular vowel curves are similar across volunteers. The displacement ranged 1–2 cm and strain value amplitude was 0.18–0.25. The displacement and strain curves from the same volunteer are reproducible. The curves produced by pronouncing “a” were the most consistent. Conclusions: The displacement and strain curves provide measures of the vocal cord stiffness and may be used to identify early vocal cord injury for oral and oropharyngeal cancer patients.
Molecular Engineering Approaches against Germs, Spores and Biofilm Formation (2014)

Thesis (Ph.D.)--University of Washington, 2014