gebhart/patrepeval huggingface dataset:
From genome to phenome--RNAi library screening and hit characterization using signaling pathway analysis. (2006)

Comprehensive, high-throughput analysis of gene function using RNA interference (RNAi)-based screens is emerging as a significant step forward for preliminary drug-target identification. Until quite recently drug target identification depended heavily on the analysis of changes in gene expression, which in turn needed to be correlated with gene function. The promise of obtaining preliminary 'gene to phenotype' information using a single high-throughput platform is propelling major investment in this area by biotechnology and pharmaceutical companies. This review discusses recent developments in the use of RNAi library screens, and the various assay formats and techniques currently in use for data analysis downstream of such screens.
Interactions with Sinefungin. (2016)

<p>The SAM analog Sinefungin is tightly bound within the MTase domain via extensive hydrogen bonding (dashed lines) and hydrophobic contacts.</p>
Precision Speed Control<!--<xref ref-type="other" rid="fn1-10.5594_J12493">*</xref>--> (1949)

A precision speed control is capable of maintaining motor speed within 1 part in 25,000 under voltage variations of plus or minus 20 per cent and load variations from zero to full load. For motion picture production this order of regulation provides the equivalent of synchronous operation without physical connection between such motors.
$-Calculus of Bounded Rational Agents: Flexible Optimization as Search under Bounded Resources in Interactive Systems (2005)

This paper presents a novel model for resource bounded computation based on process algebras. Such model is called the $-calculus (cost calculus). Resource bounded computation attempts to find the best answer possible given operational constraints. The $-calculus provides a uniform representation for optimization in the presence of limited resources. It uses cost-optimization to find the best quality solutions while using a minimal amount of resources. A unique aspect of the approach is to propose a resource bounded process algebra as a generic problem solving paradigm targeting interactive AI applications. The goal of the $-calculus is to propose a computational model with built-in performance measure as its central element. This measure allows not only the expression of solutions, but also provides the means to incrementally construct solutions for computationally hard, real-life problems. This is a dramatic contrast with other models like Turing machines, λ-calculus, or conventional process algebras. This highly expressive model must therefore be able to express approximate solutions. This paper describes the syntax and operational cost semantics of the calculus. A standard cost function has been defined for strongly and weakly congruent cost expressions. Example optimization problems are given which take into account the incomplete knowledge and the amount of resources used by an agent. The contributions of the paper are twofold: firstly, some necessary conditions for achieving global optimization by performing local optimization in time and/or space are found. That deals with incomplete information and complexity during problem solving. Secondly, developing an algebra which expresses current practices, e.g., neural nets, cellular automata, dynamic programming, evolutionary computation, or mobile robotics as limiting cases, provides a tool for exploring the theoretical underpinnings of these methods. As the result, hybrid methods can be naturally expressed and developed using the algebra.
Synthesis of certain Sulphonamides and Aminopyranoquinoline Derivatives from 4-Hydroxyquinoline with Biological Interest (1991)

Department of Chemistry, Faculty of Science, Mansoura University. Mansoura, Egypt <em>Manuscript received 2 April 1990, revised 21 November 1990, accepted 17 July 1991</em> Various sulpbonamides derivatives (3a-d) have been synthesised by the pyridine ring opening of 4-bydroxyqulnollne monoxime (la-d), and screened for their anti-bacterial activity. Furthermore. the reactivity of 4-hydroxyquinoline (1) towards different activated nitriles has been studied.
Evaluation of recycled MgO-C bricks and dead-burned dolomite fines in setting slag foaming in the electric arc furnace (2018)

Production cost reduction for the Electric Arc Furnace (EAF) technology is strongly dependent on the efficiency of the electrical energy being introduced into the metal bath. Besides EAF technology, the slag foaming process is currently applied to some other equipment for steel production aiming to save energy, productivity improvements, enhance the refractory service life and inhibit steel re-oxidation. In this way, this study involved the recycling options of Crushed MgO-C spent refractories removed from the EAF without complex and costly beneficiation, with emphasis on its application as a slag conditioner, since its composition presents high MgO content. The experiments were performed in a laboratory induction furnace and the temperature was controlled at 1700°C.The initial height of the slag was recorded and foaming briquettes added into the furnace. The experiments were carried out for 30 minutes. When the foaming process was finalized, an aliquot from the slag was collected to be analyzed by chemical analysis. Then, the metal with slag was tapped into a mold. The results indicated that the best viscosity was 0.39poise. The maximum height of foam formation was observed for a binary basicity greater than 1.2. The concentration of MgO in the slag is close to the saturation point.
Role of Ca <sup>2+</sup> -Independent Phospholipase A <sub>2</sub> in the Regulation of Inducible Nitric Oxide Synthase in Cardiac Myocytes (2000)

We have previously shown that the regulation by interleukin-1beta (IL-1beta) of inducible nitric oxide synthase (iNOS) involves phospholipase A(2) (PLA(2)) metabolites in neonatal ventricular myocytes. Based on studies in which ONO-RS-082 is used to inhibit secretory PLA(2) and methyl arachidonyl fluorophosphonate is used to inhibit cytosolic PLA(2), our data suggest that a secretory PLA(2) metabolite was involved in the regulation by IL-1beta of iNOS. In addition, a third PLA(2) isoform, which is Ca(2+) independent (iPLA(2)), has also been detected in cardiac myocytes and shown to be regulated by cytokines. We tested whether iPLA(2) metabolites are involved in the regulation by IL-1beta of iNOS with the use of bromoenol lactone (BEL), a specific and irreversible inhibitor of iPLA(2). For this, we measured IL-1beta-stimulated nitrite (NOx) production with use of the Griess reagent, prostaglandin E(2) (PGE(2)) production with use of an enzyme immunoassay, and arachidonic acid release in the presence and absence of BEL. We also detected iNOS and iPLA(2) proteins by Western blotting. Treatment with IL-1beta (5 ng/mL) for 24 hours stimulated NOx production by 8-fold and iNOS protein levels by at least 10-fold. In addition, arachidonic acid release was increased by 1.6-fold and PGE(2) production was increased by 300-fold. When neonatal ventricular myocytes were treated with 10 micromol/L BEL, both IL-1beta-stimulated PGE(2) production and arachidonic acid release were inhibited. BEL inhibited IL-1beta-stimulated NOx production and iNOS protein by 88% and 93%, respectively. Lysophosphatidic acid, but not arachidonic acid or lysophosphatidylcholine, stimulated iNOS expression. Our results indicate that an iPLA(2) metabolite, perhaps lysophosphatidic acid, may be involved in the IL-1beta-signaling pathway, regulating the synthesis of iNOS.
Optimizing Java: theory and practice (1997)

The enormous popularity of the Internet has made an instant star of the Java programming language. Java's portability, reusability, security and clean design has made it the language of choice for Web-based applications and a popular alternative to C++ for object-oriented programming. Unfortunately, the performance of the standard Java implementation, even with just-in-time compilation technology, is far behind the most popular languages today. The need for an aggressive optimizing compiler for Java is clear. Building on preliminary experience with the JavaSoft bytecode optimizer, this paper explores some of the issues that arise in building efficient implementations of Java. A number of interesting problems are presented by the Java language design, making classical optimization strategies much harder to implement. On the other hand, Java presents the opportunity for some new optimizations, unique for this language. © 1997 John Wiley & Sons, Ltd.
Visible Light Positioning Using A Single LED Luminaire (2019)

Visible light positioning (VLP) has developed rapidly with the ubiquitous lighting infrastructure in recent years. Based on classic trilateration or triangulation, VLP usually requires at least three light sources which makes it infeasible in some scenarios where sparse LED luminaries are mounted. In this paper, we focus on VLP in such scenarios and propose a VLP method based on a single LED luminaire as the light transmitter and commercial off-the-shelf smartphone as the receiver. A critical problem that needs to be addressed is to derive the accurate orientation of the smartphone. Although the inertial measurement unit of the smartphone can be used to obtain the orientation, the measurement error severely degrades the positioning accuracy. To address the measurement error, this paper innovates in exploiting projective geometry to calibrate the orientation measurements. We build an experimental platform to evaluate the proposed VLP method. The experimental results show that the proposed VLP method can achieve a submeter accuracy and the indoor positioning errors are within 0.16 m by 90%.
Stem cell properties and neural differentiation of sheep amniotic epithelial cells. (2013)

This study was designed to verify the stem cell properties of sheep amniotic epithelial cells and their capacity for neural differentiation. Immunofluorescence microscopy and reverse transcription-PCR revealed that the sheep amniotic epithelial cells were positive for the embryonic stem cell marker proteins SSEA-1, SSEA-3, SSEA-4, TRA-1-60 and TRA-1-81, and the totipotency-associated genes Oct-4, Sox-2 and Rex-1, but negative for Nanog. Amniotic epithelial cells expressed β-III-tubulin, glial fibrillary acidic protein, nestin and microtubule-associated protein-2 at 28 days after induction with serum-free neurobasal-A medium containing B-27. Thus, sheep amniotic epithelial cells could differentiate into neurons expressing β-III-tubulin and microtubule-associated protein-2, and glial-like cells expressing glial fibrillary acidic protein, under specific conditions.
Observations on helical dislocations in crystals of silver chloride (1958)

Abstract Prismatio and concentric helical prismatic dislocations are generated by the stress field which appears around a spherical glass inclusion in a silver chloride crystal when the crystal is cooled from a temperature of 370°c to room temperature. The properties of these dislocations are described and their origin is discussed.
Chip-scale modules for high-level integration in the 21st century (2002)

This paper describes a new level of integration and innovation required to meet the integrated circuit (IC)- and system-level challenges of the 21 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> century. We present a technology platform in which chip-scale modules (CSMs) provide greater functionality, higher performance, lower cost, and faster time to market for many of today's emerging products. Our approach is to build CSMs that overcome formidable integration barriers without compromising individual IC technologies. By integrating various IC technologies and their supporting components, we exceed single on-chip performance. Functionality is increased through integration, and performance is improved by maintenance of an on-chip electrical environment. Applications include integrating large blocks of memory with logic, mixing analog and digital IC technologies, and integrating high-frequency ICs with high-quality (high-Q) passive components. The CSM technology platform is poised to unlock the full potential of IC technology and unleash the innovations of designers.
The design and implementation of a full-fledged multiple DBMS (2002)

We have described our design of the multiple DBMS (MDBMS). This MDBMS enables users to access data controlled by different DBMSs as if data were managed by a single DBMS. It supports facilities for SQL queries and transactions, and considers security functions. In addition, an ODBC driver at the client site has been realized to ease the development of MDBMS applications. Several popular commercial DBMSs, including Oracle, Informix and Sybase, have been successfully integrated. The MDBMS is in operation now. However, we found the performance to be unsatisfactory. It took about several seconds to process an SQL query with single join on two relations of hundreds of tuples. We have identified the performance bottleneck to be on the retrieval of meta data. The current MDBMS Server employs a commercial DBMS to store meta data, which is necessary for processing a global query. The processing of a query is slow because it needs to retrieve the schema information via an external DBMS several times. We are currently designing a core storage manager and an access manager specifically for maintaining the meta data and the intermediate results of a global query. We expect this design to significantly improve the performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Microsoft Office Publisher 2007 Step by Step (2007)

Work at your own pace through the easy numbered steps, practice files on CD, helpful hints, and troubleshooting tips to master the fundamentals of communicating your message effectively with the latest version of Office Publisher. Youll learn how to create professional-looking marketing and business materials, such as cards, flyers, and newsletters, by working with layout and design tools. Youll even learn how to export publications to PDF format for easy distribution and how to publish presentations to the web. With Step By Step, you can take just the lessons you need or work from cover to cover. Includes an easy-search companion CD with hands-on practice files, a complete eBook, a bonus quick reference to the new user interface, and more!
Multi-Dimensional Analysis of ISA Server Logs (2009)

Network administrators are always interested in analyz-ing the activities and bandwidth usage of network users in order to manage network. Usually, third party tools are being used for such analysis, but third party tools suffer from slow response and lack of customization options. In this paper, we present a novel approach for the effective and very flexible multi-dimensional analysis of network usage, by directly analyzing the ISA Server Proxy Logs. In this approach, we accumulate the ISA Server logs into SQL Server and transform it into the dimensional model using SQL Server Integration Services. Dimensional model is a database modeling technique for the efficient analysis of large datasets. In order to evaluate the effectiveness of our proposed approach, we analyze ISA Server Proxy logs generated at a local university. response of these tools is too slow; furthermore the customization options available in these tools are also limited. In our approach, we connect ISA Server to the SQL Server so that the logs can be accumulated into the database directly. Once the logs are in the structured form, he database model is transformed into the dimensional model using SQL Server Integration Services. Dimensional model is a database design technique used to enhance the query response and for the multi-dimensional analysis of data. The approach is tested on the real time ISA Server proxy logs obtained from a local university and produced very useful multi-dimensional reports and graphs.
Usage of anterior tibial relaxation incision in treatment of elderly patients with fracture of distal tibia and fibula (2013)

Objective To evaluate the clinical results of anterior tibial relaxation incision in the treatment of elderly patients with fracture of distal tibia and fibula,and to summarize the experience of treatment.Methods Twenty-one elderly patients with distal tibial and fibular fractures with tibial fractures were treated by anterior tibial relaxation incision and internal fixation.The skin of anterior tibial incision was moved inward and sutured with deep fascia of the anterior tibial muscle tendon sheath.The anterior tibial wound was covered by free skin graft in the later.The affected limb could be early functional rehabilitation exercise.The treatment effects were observed and recorded.Results This group of 21 patients were followed up for 8-32 months(average 18.3 months).All patients underwent incision and skin graft healing well,and no patients with complications occurred.The fractures of all patients had reached clinical healing in 3-6 months (average 4.2 months) after surgery.According to Johner-Wruhs score,the final result was excellent in 14 patients,good in 5 cases and fair in 2 cases,with excellence rate of 90.5 ％.Conclusions Anterior tibial relaxation incision can be used in the treatment of elderly patients with fracture of distal tibia and fibula,since it is good for fracture reduction and fixation and is beneficial for the early rehabilitation training and the fracture healing,while the postoperative complications can be reduced by the relaxation incision.

Key words: 
Tibia and fibula;  Fracture ;  Elderly;  Relaxation incision
A BIOSYSTEMATIC SURVEY OF COREOPSIS IN EASTERN UNITED STATES AND CANADA (1976)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Bactericidal and Sterilizing Activities of Antituberculosis Drugs during the First 14 Days (2003)

Colony-forming units of Mycobacterium tuberculosis in sputum were counted at 2-day intervals in 100 patients treated with 22 regimens of isoniazid, rifampin, pyrazinamide, ethambutol, or streptomycin, given alone or in combinations. The exponential fall in colony-forming units was measured by linear regression coefficients of the log counts during the initial 2-day phase of rapid, drug-determined killing and during the subsequent 12 days of much slower sterilizing activity. The regression coefficients during the first 2 days varied significantly according to the drug; the greatest effects in multiple regression analyses were due to isoniazid (p < 0.001) and rifampin (p = 0.027). The rapid kill obtained with isoniazid was unaffected by addition of other drugs, so that a change in activity after adding an unknown drug to isoniazid would not be measurable. In multiple regression analysis of the coefficients during Days 2-14, rifampin and streptomycin had significant effects (p = 0.007 and 0.006, respectively), indicating that both drugs had important sterilizing activity, streptomycin particularly early. Isoniazid and pyrazinamide had no significant effects. In analyses of combined drug regimens only, ethambutol had an effect (p = 0.01) in reverse direction to that of rifampin, suggesting it antagonized the sterilizing activity of other drugs.
Uniaxial-stress effects on the electronic properties of carbon nanotubes (1997)

Using a semiempirical tight-binding approach modified through introduction of a deformation potential, we have calculated the effects of uniaxial stress on the electronic density of states of carbon tubules. For zigzag tubules (n,0) the gap varies linearly with stress and independently of diameter: |${\mathrm{dE}}_{\mathrm{gap}}$/d\ensuremath{\sigma}|=10.7 meV/GPa for |\ensuremath{\sigma}| \ensuremath{\prec}10 GPa, and a semiconductor to metal transition is predicted. The behavior is strongly dependent on whether n=3q,3q-1,3q+1. The armchair tubules remain metallic under all conditions studied.
Graves' Disease (2000)

Robert Graves first identified the association of goiter, palpitations, and exophthalmos in 1835, although Caleb Parry had published details of a case 10 years earlier. The discovery of a thyroid-stimulating factor that was not thyrotropin in the serum of patients with Graves' hyperthyroidism1 was followed by the identification of this stimulator as an IgG antibody.2 It is now clear that Graves' hyperthyroidism is caused by these thyroid-stimulating antibodies, which bind to and activate the thyrotropin receptor on thyroid cells.3 Graves' disease also affects the eyes (Graves' ophthalmopathy) and the skin (localized dermopathy or myxedema), but the causes of these less . . .
Characterization of <i>Colletotrichum acutatum</i> Isolates Causing Anthracnose of Almond and Peach in California (1997)

ABSTRACT The causal organism responsible for the recent outbreak of almond and peach anthracnose in California was identified and characterized as Colletotrichum acutatum. Isolates of C. acutatum from almond were found to be similar to California strawberry isolates and South Carolina peach and apple isolates of C. acutatum based on conidial morphology, temperature relationships, fungicide sensitivity, and polymerase chain reaction (PCR) methods using DNA species-specific primers. On almond, blossoms and immature or mature fruit were affected by the disease, causing direct losses of crop. On peach, the disease was observed only on mature fruit. Pathogenicity of almond and peach isolates of C. acutatum was demonstrated on wound- and nonwound-inoculated almond or peach fruit by fulfilling Koch's postulates. Conidial morphology of isolates was variable, depending on the medium or substrate used to culture the isolates. Isolates of C. acutatum from strawberry, almond, and peach were grouped together based on a similar response to temperature, with an optimal growth rate at 25 degrees C (generally less than 10 mm/day), whereas isolates of C. gloeosporioides from citrus and papaya had an optimal growth rate at 30 degrees C (generally greater than 10 mm/day). In fungicide disk assays, isolates of C. acutatum from strawberry, peach, and apple, as well as almond and peach isolates from California, were less sensitive to benomyl at 300, 600, or 1,200 mug/ml. In contrast, C. gloeosporioides isolates from citrus and papaya were very sensitive to benomyl at all concentrations evaluated. All isolates of both species were sensitive to captan (300, 600, or 1,200 mug/ml). Oligonucleotide primers were synthesized for C. acutatum, C. fragariae, or C. gloeosporioides using published DNA sequences from the internal transcribed spacer 1 region of ribosomal DNA. Thirty-two Colletotrichum isolates from almond fruit produced DNA products with a C. acutatum primer (CaInt-2) that matched products and approximate molecular weight of known C. acutatum isolates. No PCR products were produced with primers for C. gloeosporioides or C. fragariae. Isolates from citrus and papaya produced DNA products only with primers from C. gloeosporioides or C. fragariae. Thus, worldwide, anthracnose of almonds may be caused by either C. gloeosporioides, as previously reported, or by C. acutatum, as indicated in this study.