gebhart/patrepeval huggingface dataset:
Social suppression of ovarian cyclicity in captive and wild colonies of naked mole-rats, <i>Heterocephalus glaber</i> (1990)

To investigate the endocrine cause of reproductive suppression in nonbreeding female naked mole-rats, animals from 35 colonies were studied in captivity. Urinary and plasma progesterone concentrations were elevated in pregnant females (urine: 10.0-148.4 ng/mg Cr, 27 samples from 8 females; plasma: 3.6-30.0 ng/ml, 5 samples from 5 females; Days 21-40 of pregnancy) and cyclic breeding females (urine: 0.5-97.8 ng/mg Cr, 146 samples from 7 females; plasma: less than 1.0-35.4 ng/ml, 25 samples from 7 females). The latter group showed cyclic patterns of urinary progesterone, indicating a mean ovarian cycle length of 34.4 +/- 1.6 days (mean +/- s.e.m.) with a follicular phase of 6.0 +/- 0.6 days and a luteal phase of 27.5 +/- 1.3 days (19 cycles from 9 breeding females). In non-breeding females urinary and plasma progesterone values were undetectable (urine: less than 0.5 ng/mg Cr, 232 samples from 64 females; plasma: less than 1.0 ng/ml, 7 samples from 6 females). Breeding females had higher (P less than 0.001) plasma LH concentrations (3.0 +/- 0.2 mi.u./ml, 73 samples from 24 females) than did non-breeding females (1.6 +/- 0.1 mi.u./ml, 57 samples from 44 females). Urinary and plasma progesterone concentrations in non-breeding females from wild colonies situated near Mtito Andei, Kenya, were either below the assay sensitivity limit (urine: less than 0.5 ng/mg Cr, 11 females from 2 colonies; plasma: less than 1.0 ng/ml, 25 females from 4 colonies), or very low (plasma: 1.6 +/- 0.6 ng/ml, 15 females from 4 colonies). In captivity, non-breeding females removed from their colonies (i.e. the dominant breeding female) and either paired directly with a non-breeding male (N = 2), or removed and housed singly for 6 weeks before pairing with a non-breeding male (N = 5) may develop a perforate vagina for the first time in as little as 7 days. Urinary progesterone concentrations rose above 2.0 ng/mg Cr (indicative of a luteal phase) for the first time 8.0 +/- 1.9 days after being separated. These results suggest that ovulation is suppressed in subordinate non-breeding female naked mole-rats in captive and wild colonies, and show that plasma LH concentrations are significantly lower in these non-breeding females. This reproductive block in non-breeding females is readily reversible if the social factors suppressing reproduction are removed.
Pharmacokinetic disposition in sheep of various vitamin E preparations given orally or intravenously (1988)

1. Increases in plasma tocopherol concentrations were compared in sheep after a single oral administration of (per kg body-weight): 67 mg D- and 91 mg DL-epimers of alpha-tocopherol, and 74 mg D- and 100 mg DL-epimers of alpha-tocopheryl acetate, or intravenous administration of DL-alpha-tocopherol and DL-epimers of DL-alpha-tocopheryl acetate. 2. The results showed that biological availability was higher after D-alpha-tocopherol dosing than after the other forms. Intravenous administration of D-alpha-tocopherol acetate was a more effective way of dosing in sheep than equivalent intravenous amounts of DL-alpha-tocopheryl acetate or DL-alpha-tocopherol.
Modifying JPEG Binary Arithmetic Codec for Exploiting Inter/Intra-Block and DCT Coefficient Sign Redundancies (2012)

This article presents four modifications to the JPEG arithmetic coding (JAC) algorithm, a topic not studied well before. It then compares the compression performance of the modified JPEG with JPEG XR, the latest block-based image coding standard. We first show that the bulk of inter/intra-block redundancy, caused due to the use of the block-based approach by JPEG, can be captured by applying efficient prediction coding. We propose the following modifications to JAC to take advantages of our prediction approach. 1) We code a totally different DC difference. 2) JAC tests a DCT coefficient by considering its bits in the increasing order of significance for coding the most significant bit position. It causes plenty of redundancy because JAC always begins with the zeroth bit. We modify this coding order and propose alternations to the JPEG coding procedures. 3) We predict the sign of significant DCT coefficients, a problem is not addressed from the perspective of the JPEG decoder before. 4) We reduce the number of binary tests that JAC codes to mark end-of-block. We provide experimental results for two sets of eight-bit gray images. The first set consists of nine classical test images mostly of size 512 × 512 pixels. The second set consists of 13 images of size 2000 × 3000 pixels or more. Our modifications to JAC obtain extra-ordinary amount of code reduction without adding any kind of losses. More specifically, when we quantize the images using the default quantizers, our modifications reduce the total JAC code size of the images of these two sets by about 8.9 and 10.6%, and the JPEG Huffman code size by about 16.3 and 23.4%, respectively, on the average. Gains are even higher for coarsely quantized images. Finally, we compare the modified JAC with two settings of JPEG XR, one with no block overlapping and the other with the default transform (we denote them by JXR0 and JXR1, respectively). Our results show that for the finest quality rate image coding, the modified JAC compresses the large set images by about 5.8% more than JXR1 and by 6.7% more than JXR0, on the average. We provide some rate-distortion plots on lossy coding, which show that the modified JAC distinctly outperforms JXR0, but JXR1 beats us by about a similar margin.
Mitochondrial nitric oxide synthase, a voltage-dependent enzyme, is responsible for nitric oxide diffusion to cytosol (2006)

The mitochondrial metabolic state regulates the rate of mitochondrial NO production and release to the cytosol. Nitric oxide release of rat heart mitochondria decreased markedly from 2.2 to 1.2 nmol NO/min. mg protein in the state 4 to state 3 transition. The activity of mtNOS, responsible for NO release, is driven by the membrane potential and not by intramitochondrial pH changes. The release of NO by rat liver mitochondria showed an exponential dependence on membrane potential. A similar behavior was reported for heart mitochondrial H2O2 production. The fraction of heart cytosolic NO provided by diffusion from mitochondria is 90%. The intramitochondrial concentrations of L-arginine and NADPH are higher than their KM values, and the changes in their concentrations in the state 4-state 3 transition are not enough to explain the changes in NO release. These data indicate that the redox state of the respiratory chain components regulates H2O2 production and mitochondrial membrane potential modulates NO release, and support the speculation that NO and H2O2 are a biological signal that reports a high mitochondrial energy charge to the cytosol. The marked regulation of mtNOS activity, as a voltage-dependent enzyme and at the physiological range of membrane potentials, makes mtNOS a highly sensitive enzyme that in turn regulates mitochondrial O2 uptake and H2O2 production.
Biochemical Aspects of Active Transport (1967)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
783. Some aminophosphines (1962)

G. Ewart, D. S. Payne, A. L. Porte and A. P. Lane, J. Chem. Soc., 1962, 3984 DOI: 10.1039/JR9620003984
Automatic Detection of Pit Structures in Airborne Laser Scanning Data (2012)

ABSTRACT This paper describes a new method for the automatic detection of pit structures in airborne laser scanning data collected with at least five emitted pulses per square metre. Oppland County, Norway, has a large number of ancient iron production sites and hunting systems. Today, these are manifested as pits in the ground. The iron production sites were used 1400–700 yr ago, and consist of charcoal burning pits, often located in groups of four around a central oven, which also occasionally can be located as a small mound. The hunting systems were used 2000–500 yr ago, and consisted of concealed pitfall traps and wooden fences, located on deer trekking routes. The fences are gone, but the pits remain. Many of the iron production sites and hunting systems are located in forested areas. The current, traditional mapping of these is relatively poor, with many individual pits missing, and poor positional accuracy of the ones that are mapped. This means that overlays of cultural heritage sites cannot be trusted when planning new highways, residential areas, cabins, etc. Experience suggests that automatic detection is clearly superior to visual inspection of the lidar data in finding small pits or pits that are not easily visible. However, visual inspection is better at finding additional information as human interpretation based on archaeological knowledge can be applied. Combining these two methods secures a very good basis for subsequent field survey. In conclusion, we demonstrate that automatic detection of hunting systems and iron extraction sites in lidar data is a valuable tool in combination with visual inspection of the lidar data, prior to field survey. Provided that the point density of the lidar data is high enough, the field survey can be accomplished ten times faster compared with the traditional approach without lidar data. Copyright © 2012 John Wiley & Sons, Ltd.
The experimental characteristics of a wide dynamic range crossed-field gun (1970)

This paper briefly describes the experimental verification of the properties of a wide dynamic range crossed-field gun [1]. This gun, which is a combination of a Kino short gun (or it could be a Kino long gun) and a two-section transformer region, can be used to inject electron beams (with cathode current density varying over a wide range) into the interaction region under optimum conditions and under conditions of a fixed magnetic field. The beam injection level and its injection velocity can also be varied over a wide range by suitably adjusting the electric fields in the two sections of the transformer. The fabrication of the experimental tube is also briefly described.
DIFFERENTIAL MODE DELAY (DMD) FOR MULTIMODE FIBER TYPES AND ITS RELATIONSHIP TO MEASURED PERFORMANCE (2005)

With the introduction of Vertical Cavity Surface Emitting Lasers (VCSEL’s) used with multimode fiber (MMF), Differential Mode Delay (DMD), modal interference effects and the influence of connector interfaces are found to reduce the observed bandwidth of multimode fibers (MMF’s). In this study the performance of three example MMF’s is characterized by measuring DMD, effective modal bandwidth, and Bit Error Rate (BER) on the same three fibers. Fiber length is also considered. Controlling the spatial locations of the launch pulses, we develop methods aimed to certify the performance of optical fiber for 10Gb / s Ethernet. The source for these measurements was an 850 nm VCSEL.
Supernatants from cultured human epidermal keratinocytes stimulate angiogenesis (1984)

Conditioned media from three different strains of human epidermal keratinocytes in culture were assayed on the chorioallantoic membrane of the chick embryo. Vascular responses were examined 4 days later stereo-microscopically and compared with controls--unconditioned medium and medium incubated with 3T3 cells. Specimens were also collected after 1, 2, 3 and 4 days for serial histological examination. Media from all three strains of keratinocytes stimulated statistically significant vascular growth relative to controls. Leukocytic infiltration was not demonstrated histologically at any time. In addition, quantitation of ectodermal epithelial hyperplasia in experimental groups did not reveal any significant difference when compared with controls. These results have demonstrated that epidermis may directly encourage vascular growth in the absence of significant inflammation.
Space management in a DIY store analysing consumer shopping paths with data‐tracking devices (2007)

Purpose Space management is an essential part of successful retailing. Good space management requires accurate data about consumer behaviour. Traditionally, these data have been collected through panel interviews, camera tracking and in‐store observation. Their nature is subjective to a greater or lesser extent. Modern technology makes it possible also to use more objective methods, such as the wireless local network (WLAN) and the radio frequency identification (RFID). This paper seeks to examine the possibilities WLAN provides for facilities management studies. Design/methodology/approach The empirical data were collected from 866 consumer shopping paths in a large do‐it‐yourself (DIY) store using WLAN technology. The data have been analysed with GIS tools. Findings The results show that WLAN has great potential for accurate and objective data collection processes and modelling. This method creates more objective results than traditional consumer tracking methods. Research limitations/implications Only a small amount of previous research has been done and the relevant amount of source material was very limited. This study gives new methodological viewpoints. This is also the main limitation of this study. More empirical data and analysis are definitely needed in order to achieve more reliability and validity. Practical implications This paper gives direct advice in the form of pros/cons for retailers in the usage of WLAN in the consumer tracking process. Originality/value Similar research methods have been utilised only a few times before and only in the grocery retailing industry. This is the first time a DIY store has been analysed.
Isolation and Purification of Primary Oligodendrocyte Precursors (1997)

Oligodendrocytes are the myelinating cells of the central nervous system, and are avidly studied by investigators interested in neural cell lineages, myelination, multiple sclerosis, and oligodendroglioma. This unit presents a strategy for manipulating the division and differentiation of oligodendrocyte progenitors by isolating O-2A progenitors from optic nerve and then purifying and expanding them by culture in a defined medium supplemented with platelet-derived growth factor (PDGF) plus basic fibroblast growth factor (bFGF). Cells are then allowed to differentiate through removal of the growth factors. A protocol is also provided for monitoring the cell type composition of the cultures by immunohistochemistry. In addition to making it possible to generate large numbers of cells, this approach allows access to intermediate differentiation stages. Cells can thus be studied as they differentiate into oligodendrocytes, making the actual process of differentiation open to examination.
Advances in Enzymology: <i>Advances in Enzymology and Related Subjects</i> . Edited by F. F. Nord and C. H. Werkman. Vol. I. 433 pp. + 56 illustrations. New York: Interscience Publishers, Inc. $5.50. 1941. (1941)

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Cuff Pressure of Endotracheal Tubes After Changes in Body Position in Critically Ill Patients Treated With Mechanical Ventilation (2014)

Simple changes in patients' positioning can result in potentially harmful cuff pressures.
Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase (2004)

The Rho family of small GTPases play a pivotal role in the dynamic regulation of the actin cytoskeleton. Recent studies have suggested that these signalling proteins also have wide-ranging functions in membrane trafficking pathways. The Rho family member RhoB was shown to localise to vesicles of the endocytic compartment, suggesting a potential function in regulation of endocytic traffic. In keeping with this, we have previously shown that expression of active RhoB causes a delay in the intracellular trafficking of the epidermal growth factor (EGF) receptor; however, the site of action of RhoB within the endocytic pathway is still unknown. RhoB exists as two prenylated forms in cells: geranylgeranylated RhoB (RhoB-GG) and farnesylated RhoB (RhoB-F). Here we use farnesyltransferase inhibitors (FTIs) to show that prenylation specifies the cellular localisation of RhoB. RhoB-GG localises to multivesicular late endosomes and farnesylated RhoB (RhoB-F) localises to the plasma membrane. The gain of endosomal RhoB-GG elicited by FTI treatment reduces sorting of EGF receptor to the lysosome and increases recycling to the plasma membrane. Ultrastructural analysis shows that activation of RhoB through drug treatment or mutation has no effect the sorting of receptor into late endosomes, but instead inhibits the subsequent transfer of late endosomal receptor to the lysosome.
Automatic generation of test sequences form EFSM models using evolutionary algorithms (2008)

Automated test data generation through evolutionary testing (ET) is a topic of interest to the software engineering community. While there are many ET-based techniques for automatically generating test data from code, the problem of generating test data from an extended finite state machine (EFSMs) is more complex and has received little attention. In this paper, we introduce a novel approach that addresses the problem of generating input test sequences that trigger given feasible paths in an EFSM model by employing an ET-based technique. The proposed approach expresses the problem as a search for input parameters to be applied to a set of functions to be called sequentially. In order to apply ET-based technique, a new fitness function is introduced to cope with the case when a test target involves calls to a set of transitions sequentially. We evaluate our approach empirically using five sets of randomly generated paths through two EFSM case studies: for INRES and class 2 transport protocols. In the experiments, we apply random and the proposed ET-based which utilizes our new fitness function. Experimental results show that the proposed approach produces input test sequences that trigger all the feasible paths used with a success rate of 100%, however, the random technique failed in most cases with a success rate of
Forecasting Treatment Responses Over Time Using Recurrent Marginal Structural Networks (2018)

Electronic health records provide a rich source of data for machine learning methods to learn dynamic treatment responses over time. However, any direct estimation is hampered by the presence of time-dependent confounding, where actions taken are dependent on time-varying variables related to the outcome of interest. Drawing inspiration from marginal structural models, a class of methods in epidemiology which use propensity weighting to adjust for time-dependent confounders, we introduce the Recurrent Marginal Structural Network - a sequence-to-sequence architecture for forecasting a patient's expected response to a series of planned treatments. Using simulations of a state-of-the-art pharmacokinetic-pharmacodynamic (PK-PD) model of tumor growth, we demonstrate the ability of our network to accurately learn unbiased treatment responses from observational data, exhibiting robustness to changes in the policy of treatment assignments, and performance gains over benchmarks.
Spectral and two-place decomposition techniques in reversible logic (2003)

A digital circuit is reversible if it maps each input vector into a unique output vector. Reversible circuits can lead to low-power CMOS implementations and are also of interest in optical and quantum computing. In this paper, we consider the synthesis of reversible logic assuming primitive reversible devices such as Feynman, Toffoli and Fredkin gates. In particular, we consider the use of Rademacher-Walsh spectral techniques and two-place decompositions of Boolean functions. Preliminary results are given for reversible and nonreversible functions and show that the approaches described do indeed show promise.
A Continuous Spectrophotometric Assay for NADPH-cytochrome P450 Reductase Activity Using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide (2005)

NADPH-cytochrome P450 reductase (CPR) transfers electrons from NADPH to cytochrome P450 and also catalyzes the one-electron reduction of many drugs and foreign compounds. Various spectrophotometric assays have been performed to examine electron-accepting properties of CPR and its ability to reduce cytochrome b5, cytochrome c, and ferricyanide. In this report, reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) by CPR has been assessed as a method for monitoring CPR activity. The principle advantage of this substance is that the reduction of MTT can be assayed directly in the reaction medium by a continuous spectrophotometric method. The electrons released from NADPH by CPR were transferred to MTT. MTT reduction activity was then assessed spectrophotometrically by measuring the increase of A610. MTT reduction followed classical Michaelis-Menten kinetics (K(m)= 20 microM, k(cat)= 1,910 min(-1)). This method offers the advantages of a commercially available substrate and short analysis time by a simple measurement of enzymatic activity of CPR.
An Embedded Space-Time Coding (STC) Scheme for Broadcasting (2007)

An embedded space-time coding method is proposed for wireless multimedia broadcast with heterogeneous receivers. In the proposed system, a transmitter sends out multi-layer source signals by encoding different layers with different space-time codes. Then, a receiver can retrieve a different amount of information depending on the number of its antennas. The receiver with only one antenna can decode only the base layer information with a low complexity while the receiver with more antennas can retrieve more layers of information. We also investigate a differential design of the embedded space-time system, which is used when the channel state information (CSI) is unknown to the receiver. Both analytic and experimental results are provided to demonstrate the performance of the proposed system. Differential detection with Kalman filtering is also investigated to help improve performance
Intraocular pressure and diabetic retinopathy. (1977)

Between intraocular pressure (I.O.P.) and the metabolic carbohydrate disturbance is a relationship: 1. diabetics frequently show primary open angle-galucoma; 2. as the diabetic retinopathy progresses towards stage III (Pr.), IOP decreases; 3. as diabetics exhibit dilatation of veins, increased blood viscosity, arteriolar narrowing and increased I.O.P. central retinal vessel disease with hemorrhages occurs redily; 4. capillary hemorrhages, periapaillary and macular oedema may be caused by increased oncotic pressure with acidosis of the blood; hyperglycemia with ketosis goes together with decreased I.O.P.; 5. only mild I.O.P.-rise may be considered as usefull to prevent hemorrhages by reducing retinal blood flow resulting subsequently from reduced uveal blood flow; 6. local application of glucocorticoids with permanent control of visual fields and I.O.P. should be a good additional treatment for diabetic retinopathy; unfortunately only very few cases are responsive to increase of I.O.P. by glucocorticoids; 7. it is important that prolactine levels in the blood are higher in the morning before the patient wakes up: this goes together with the morning I.O.P.-rise in glaucoma patients. Decreased activity of the hypophysis improves the diabetic retinopathy; this is contradictory to the beneficial effect of mild I.O.P.-rise.