gebhart/patrepeval huggingface dataset:
Linkage of the gene for an X-linked mental retardation disorder to a hypervariable (AGAT)n repeat motif within the human hypoxanthine phosphoribosyltransferase (HPRT) locus (Xq26). (1991)

We recently reported a new X-linked mental retardation (XLMR) disorder in a four-generation family of Dutch descent. Features included Dandy-Walker malformation, basal ganglia disease, and seizures. Twenty-six family members, including two living affected males and two obligate carriers, were available for study. No evidence of linkage was observed between the disease locus and RFLPs from several X-chromosome regions, including Xp21-p22 (13 markers), proximal Xq (four markers), and Xq28 (three markers). However, a new hypervariable short tandem repeat (STR) within the HPRT gene at Xq26 showed positive linkage to the disease locus, with a maximum lod score of 2.19 at a recombination fraction of 0. A second hypervariable marker in Xq26, the dinucleotide repeat XL90A3 (DXS425), showed a lod score of .84 at a recombination fraction of .11. Both the HPRT and DXS425 markers were typed in 40 CEPH families, and subsequent multipoint linkage analysis showed the following order: Xcen-DXS425-(HPRT,XLMR)-F9-qter. HPRT and these flanking markers are therefore useful for carrier detection and prenatal diagnosis in this family. This study illustrates that hypervariable STRs will be powerful tools for linkage analysis and genetic diagnosis, particularly when relatively small families are involved.
A low-power CMOS digitally synthesized 0-13 MHz agile sinewave generator (2002)

A low-power monolithic 1 /spl mu/m CMOS IC generates a 26 MHz-wide single-sideband, frequency-hopped spread-spectrum waveform for wireless transmission in the 902-928 MHz unlicensed ISM band. A direct digital frequency synthesizer (DDFS) on this IC produces 10b samples of sine and cosine waveforms whose frequency is selected with an 11b input word, followed by an on-chip 10b D/A converter (DAC) to convert the DDFS output into a sampled-data analog signal. Simplifications in architecture and circuits reduce dissipation of this 2.9/spl times/4.9 mm/sup 2/ IC to 40 mW at 40 MHz with 3 V supply.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Agricultural production on the water protected area on the pumping sites in the Zagreb region (2003)

Na podrucju Grada Zagreba i Zagrebacke županije danas se koristi voda iz ukupno 13 vodocrpilista razlicitog kapaciteta. Odluke o vodozastitnim zonama donesene su samo za neke od njih, a neke su u fazi prijedloga. Vodozastitne zone zauzimaju veliki prostor na kojemu je organizirana poljoprivredna proizvodnja. Svakako, da su otvorena pitanja kako je poljoprivredna proizvodnja organizirana, koji su inputi, kakva je njena ucinkovitost, te da li postoji alternativa takvoj proizvodnji. Zagrebacka županija na svojim povrsinama krenula je u realizaciju projekta. Buduci pucanstvo Grada Zagreba koristi vodu za pice dijelom iz vodocrpilista sa podrucja Zagrebacke županije, a neka vodozastitna podrucja administrativno se nalaze u Županiji i u Gradu cijeli projekt radit ce se i za Grad Zagreb i Zagrebacku županiju. Na temelju navedenih polazista postavljeni su sljedeci ciljevi ovog projekta: 1. na podrucju Zagrebacke županije i Grada Zagreba u dolini Save utvrditi postojeca vodozastitna podrucja, 2. na temelju analize hidrogeoloskih i pedoloskih obilježja, te analize kakvoce tala i podzemne vode, ekoloski valorizirati pojedina vodozastitna podrucja, 3. unutar vodozastitnih podrucja utvrditi postojecu poljoprivrednu proizvodnju, 4. utvrditi ekonomsku ucinkovitost postojece poljoprivredne proizvodnje, 5. utvrditi stanje biljne proizvodnje i na temelju toga dati smjernice za promjenu stanja i predložiti mjere za ostvarenje tih smjernica, 6. ukoliko se na temelju postojeceg stanja utvrdi da je to potrebno, preporuciti alternativne oblike poljoprivredne proizvodnje.
Inhibition of human and bovine sperm acrosin by divalent metal ions. Possible role of zinc as a regulator of acrosin activity (1982)

Human and bovine spermatozoa have been collected and washed repeatedly with isotonic saline to remove seminal plasma inhibitors and activate the acrosin. Then the acrosin activity of the cells was assayed with alpha-N-Benzoyl-DL-Arg-beta-naphthylamide (BANA). It was found that the surface-bound enzyme was not inhibited by high molecular weight inhibitors of trypsin but was markedly inhibited by low molecular weight trypsin inhibitors. Divalent metals (Zn++, Cu++, Hg++, Co++, Cd++) were all efficient inhibitors of acrosin on the washed cells. It was shown that the removal of zinc or copper from acrosin completely restored activity. It is proposed that the different levels of zinc in the male and female genital tract regulate acrosin activity. Aged cells released a soluble acrosin which was inhibited by serum and seminal plasma inhibitors of trypsin-like enzymes as well as by zinc ions in an identical manner to the surface-bound enzyme.
Behavioural variation and plasticity along an invasive ant introduction pathway (2018)

Once established in new areas, introduced species may exhibit changes in their biology due to phenotypic plasticity, novel selection pressures and genetic drift. Moreover, the introduction process itself has been hypothesised to act as a selective filter for traits that promote invasiveness. We tested the hypothesis that behaviours thought to promote invasiveness-such as increased foraging activity and aggression-are selected for during invasion by comparing traits among native and introduced populations of the widespread Argentine ant (Linepithema humile). We studied Argentine ant populations in the native range in Argentina and in three invaded regions along an introduction pathway: California, Australia and New Zealand. In each region, we set up 32 experimental colonies to measure foraging activity and interspecific aggression in a subset of the study regions. These colonies were subject to experimental manipulation of carbohydrate availability and octopamine, a biogenic amine known to modulate behaviour in insects, to measure variation in behavioural plasticity. We found variation in foraging activity among populations, but this variation was not consistent with selection on behaviour in relation to the invasion process. We found that colonies with limited access to carbohydrates exhibited unchanged exploratory behaviour, but higher exploitation activity and lower aggression. Colonies given octopamine consistently increased foraging behaviour (both exploration and exploitation), as well as aggression when also sugar-deprived. There was no difference in the degree of behavioural response to our experimental treatments along the introduction pathway. We did not find support for selection of behavioural traits associated with invasiveness along the Argentine ant's introduction pathway or clear evidence for an association between the introduction process and variation in behavioural plasticity. These results indicate that mechanisms promote behavioural variation in a similar fashion both in native and introduced ranges. Our results challenge the assumption that introduced populations always perform better in key behavioural traits hypothesised to be associated with invasion success.
Association of medically unexplained fatigue with ACE insertion/deletion polymorphism in gulf war veterans (2004)

Genes associated with muscle metabolism and physical endurance were evaluated for variants that may contribute to the etiology of medically unexplained severe and chronic fatigue. Subjects included 49 Gulf War veterans and 61 nonveterans with chronic fatigue syndrome (CFS) or idiopathic chronic fatigue (ICF) and 30 veterans and 45 nonveterans who served as healthy controls. Increased risk for CFS/ICF was associated with alterations of the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene within the Gulf War veteran sample only. The I allele frequency was decreased in affected versus unaffected veterans (0.15 versus 0.48; odds ratio [OR], 5.08; 95% confidence interval [CI], 1.97-13.35; P < 0.0001). Correspondingly, the II genotype was decreased fourfold in affected veterans (0.08 versus 0.35; OR = 5.87; 95% CI: 1.21-28.36; P = 0.02), and the DD genotype was increased twofold (0.78 versus 0.39; OR, 5.4; 95% CI, 1.6-18.4; P = 0.007). Veterans with the DD genotype were eight times more likely to develop CFS/ICF than were those with the II genotype (OR, 8.30; 95% CI, 1.50-56.09; P = 0.009).
Helium desorption from Fe and V by atomic diffusion and bubble migration (1991)

Thermal helium desorption from homogeneously implanted iron and vanadium foils was investigated during linear heating and isothermal annealing, respectively. The isothermal experiments showed an initial period with a square-root dependence of the desorbed helium on time, characteristic of atomic helium diffusion, followed by a reduction of desorption due to clustering. The substitutional helium atoms migrate by a dissociative mechanism, with dissociation energies of 1.4\ifmmode\pm\else\textpm\fi{}0.3 eV for both metals. Up to temperatures of 600 K (Fe) and 700 K (V), retrapping was dominated by irradiation-induced vacancies. At higher temperatures diffusion times became unmeasurably small. Retention of helium in the specimens indicated that di-helium clusters are stable up to 673 K in Fe and up to 773 K in V. Desorption after clustering was analyzed by comparison with models of bubble coarsening. The vanadium results were best described by bubble migration via surface diffusion at all temperatures investigated (573--1173 K), while the iron data from 900 to 1184 K indicated bubble migration by volume diffusion as the prevalent coarsening mechanism.
Development of a real time activity monitoring Android application utilizing SmartStep (2016)

Footwear based activity monitoring systems are becoming popular in academic research as well as consumer industry segments. In our previous work, we had presented developmental aspects of an insole based activity and gait monitoring system-SmartStep, which is a socially acceptable, fully wireless and versatile insole. The present work describes the development of an Android application that captures the SmartStep data wirelessly over Bluetooth Low energy (BLE), computes features on the received data, runs activity classification algorithms and provides real time feedback. The development of activity classification methods was based on the the data from a human study involving 4 participants. Participants were asked to perform activities of sitting, standing, walking, and cycling while they wore SmartStep insole system. Multinomial Logistic Discrimination (MLD) was utilized in the development of machine learning model for activity prediction. The resulting classification model was implemented in an Android Smartphone. The Android application was benchmarked for power consumption and CPU loading. Leave one out cross validation resulted in average accuracy of 96.9% during model training phase. The Android application for real time activity classification was tested on a human subject wearing SmartStep resulting in testing accuracy of 95.4%.
Signal Cable Selection for the VERITAS Observatory (2003)

We describe electrical and mechanical tests performed on various coaxial cables to characterize their electrical properties and reliabilities. We use these properties, combined with additional information concerning weight, diameter, and cost, to select the optimum signal cables for the VERITAS observatory. We find significant advantages in using RG-59 Coaxial cable over traditional RG-58 cable. Stranded core RG-59 results in an 30-50% increase in effective mirror area over RG 58; solid core RG59 would result in a 84% increase in effective mirror area. Reliability tests demonstrate that although RG59 solid core will fatigue and fail after repeated twisting, this fatigue would result in a loss of approximately 10 cables over the lifetime of the VERITAS array.
(2,9 : 6,12‐η‐2,3,5,6‐Tetrakis(methylene)‐bicyclo[2.2.2]octane)zirconocene, an Isolable Bis(olefin)zirconium(<scp>II</scp>) Compound (1982)

Abstract The complete manuscript of this communication appears in: Angew. Chem. Suppl. 1982 , 1746. DOI: 10.1002/anie.198217460
Phononic Band Gaps in 2D Quadratic and 3D Cubic Cellular Structures (2015)

The static and dynamic mechanical behaviour of cellular materials can be designed by the architecture of the underlying unit cell. In this paper, the phononic band structure of 2D and 3D cellular structures is investigated. It is shown how the geometry of the unit cell influences the band structure and eventually leads to full band gaps. The mechanism leading to full band gaps is elucidated. Based on this knowledge, a 3D cellular structure with a broad full band gap is identified. Furthermore, the dependence of the width of the gap on the geometry parameters of the unit cell is presented.
<title>Optimization of magneto-optical spatial light modulators for neural networks</title> (1990)

The performance of neural networks with Ceedback is determined by electrically addressable magneto-optical (MO) spatial light . modula-'' tors (5LM). It was shown that MO SLM may be used. in neural networks but it''s necessary to modificate traditional MO SLM in order to achi eve high switching rate. In this work we present the xnod. ificated MO SLM structure MO media''s physical properties optimized. for achieving high rate switching the MO SLM operational margin and the way$ of its widening. 1 . T- TION An important role in artificial neural networks belongs to electrically addressible programmable SLM. They are particu]ry important if feedback is considered in neural network architecture''. The major requirements to SLIvI''s are high rate switching time providing effecti ye itteration process and high reliability. Among known up to date types of SLM (liquid crystalline RZLT ceramics etc) most attractive are recently developed MO SLM based on epitaxial films of Bisubsti tut?d iron garnet (BiRIG). Two variants of MOSLM''s are conimercially produced on of which (LISA ELSP etc) is oriented for nonmechanicalprinters while the other (SIGHT MOD Semetex) is developed mainly for plane display sys tems. Some of above mentioned MOSLM types have sufficient high rate switching time (typical frame rate for 128x128 SIGHT MOD is 20 ms). In SIGHT MOD variant with 128x128 array where nominal line resistance is in the range of 40-60 Ohm thermal limitation determine
Altered Expression of Oligodendrocyte and Neuronal Marker Genes Predicts the Clinical Onset of Autoimmune Encephalomyelitis and Indicates the Effectiveness of Multiple Sclerosis–Directed Therapeutics (2014)

Experimental autoimmune encephalomyelitis (EAE) is a valuable model for studying immunopathology in multiple sclerosis (MS) and for exploring the interface between autoimmune responses and CNS tissue that ultimately leads to lesion development. In this study, we measured gene expression in mouse spinal cord during myelin oligodendrocyte gp35-55 peptide-induced EAE, using quantitative RT-PCR, to identify gene markers that monitor individual hallmark pathological processes. We defined a small panel of genes whose longitudinal expression patterns provided insight into the timing, interrelationships, and mechanisms of individual disease processes and the efficacy of therapeutics for the treatment of MS. Earliest transcriptional changes were upregulation of Il17a and sharp downregulation of neuronal and oligodendrocyte marker genes preceding clinical disease onset, whereas neuroinflammatory markers progressively increased as symptoms and tissue lesions developed. EAE-induced gene-expression changes were not altered in mice deficient in IKKβ in cells of the myeloid lineage compared with controls, but the administration of a selective inhibitor of soluble TNF to mice from the day of immunization delayed changes in the expression of innate inflammation, myelin, and neuron markers from the presymptomatic phase. Proof of principle that the gene panel shows drug screening potential was obtained using a well-established MS therapeutic, glatiramer acetate. Prophylactic treatment of mice with glatiramer acetate normalized gene marker expression, and this correlated with the level of therapeutic success. These results show that neurons and oligodendrocytes are highly sensitive to CNS-directed autoimmunity before the development of clinical symptoms and immunopathology and reveal a role for soluble TNF in mediating the earliest changes in gene expression.
Long-Term Outcomes of Patients with Advanced Mantle Cell Lymphoma Treated with Allogeneic Hematopoietic Cell Transplantation after Nonmyeloablative Conditioning (2015)

Previous studies have shown that a subset of patients with relapsed Mantle cell lymphoma (MCL) benefit from nonmyeloablative allogeneic hematopoietic stem cell transplant (HCT), but literature is lacking regarding their long-term outcomes. We examined long-term survivals, resolution of chronic graft-versus-host-disease, and predictive factors in a large group of patients with MCL. Seventy MCL patients, age 32 to 75 yrs, were conditioned with 2 Gy TBI alone or combined with fludarabine +/- rituximab followed by HCT from related (n=35) or unrelated (n=35) donors. Table 1 summarizes patient and transplant-related characteristics. Proportional hazards models were used to estimate the hazards of relapse or mortality after adjustment for known risk variables. After a median follow-up of 7.1 (0.2-12.8) yrs, 34 patients were alive, 30 in continued remission and 4 after salvage therapies given for progression (n=1) or relapse (n=3). The 5-yr incidence of non-relapse mortality (NRM) for all 70 patients was 28%. The 5-yr rate of relapse was 26%, while those of overall (OS) and disease-free survival (DFS) were 55% and 46%, respectively (Figure 1). Among 33 pts with sufficient follow-up, 10-yr NRM, relapse, OS and DFS rates were 41%, 18%, 44% and 41%, respectively. Eighty percent of surviving patients were off immunosuppression at last follow-up, with a median time to cessation of 35 (range 1-95) months. Among the 34 surviving patients, the median Karnofsky performance status at last contact was 90%. Relapsed/refractory disease at time of HCT predicted a higher rate of relapse (HR 2.94, P=0.05) but not OS at 5 (51% versus 58%, p=0.29) or 10 yrs (43% versus 45%, p=0.89). High-risk CMV status predicted inferior OS (HR 2.32 p=0.02) and DFS (HR 2.22 p=0.03). Low CD3 dose (HR 2.04 P=0.05) predicted DFS. We conclude that some MCL patients given nonmyeloablative allogeneic HCT may achieve long-term survival and come off IS, despite having relapsed or refractory disease at the time of HCT. Future studies addressing appropriate timing of allogeneic HCT versus non-HCT therapies for patients with MCL are needed.Table 1Patient CharacteristicsMedianRangeAge (years)5732-75N%SexF1724M5376Conditioning regimen2 Gy TBI462 Gy TBI + Auto462 Gy TBI + Flu 30 mg/m2 x 355792 Gy TBI + Flu 30 mg/m2 x 3 + Rituxan572 Gy TBI + Rituxan23Donor typeHLA matched related3347HLA matched unrelated2941HLA 1 antigen mismatched811GVHD prophylaxisCyclosporine/MMF4970Cyclosporine/MMF/Rapamycin23Tacrolimus/MMF1521Tacrolimus/MMF/Rapamycin46HCTCI012171- 22637> 33043Number of prior regimens1 - 215213 - 427395 - 61623>71217Previous autologous transplantFailed2840Tandem auto/allo710No3550Disease status at HCTCR2637PR1927Relapsed/Refractory2536Bulky lymphadenopathy (5 cm or >)Y1217N5883CMV riskHigh3854Intermediate811Low2434 Open table in a new tab
ChemInform Abstract: Design of Receptors for Urea Derivatives Based on the Pyrido(3,2‐g) indole Subunit. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Description and validation of a new automated surveillance system for <i>Clostridium difficile</i> in Denmark (2017)

The surveillance of Clostridium difficile (CD) in Denmark consists of laboratory based data from Departments of Clinical Microbiology (DCMs) sent to the National Registry of Enteric Pathogens (NREP). We validated a new surveillance system for CD based on the Danish Microbiology Database (MiBa). MiBa automatically collects microbiological test results from all Danish DCMs. We built an algorithm to identify positive test results for CD recorded in MiBa. A CD case was defined as a person with a positive culture for CD or PCR detection of toxin A and/or B and/or binary toxin. We compared CD cases identified through the MiBa-based surveillance with those reported to NREP and locally in five DCMs representing different Danish regions. During 2010-2014, NREP reported 13 896 CD cases, and the MiBa-based surveillance 21 252 CD cases. There was a 99·9% concordance between the local datasets and the MiBa-based surveillance. Surveillance based on MiBa was superior to the current surveillance system, and the findings show that the number of CD cases in Denmark hitherto has been under-reported. There were only minor differences between local data and the MiBa-based surveillance, showing the completeness and validity of CD data in MiBa. This nationwide electronic system can greatly strengthen surveillance and research in various applications.
Quantification of silylated organic compounds using gas chromatography coupled to ICP-MS (2002)

Gas chromatography-inductively coupled plasma mass spectrometry (GC-ICP-MS) has been used for quantification of n-alkanols (butanol, pentanol, hexanol and heptanol) after silylation using N-methyl-N-trimethylsilyltrifluoracetamide (MSTFA) in pyridine, thus introducing a silicon atom for labelling. External and internal calibrations have been performed, which show identical sensitivities for the compounds tested and therefore facilitate a substance independent quantification. Our first results revealing an absolute and a relative detection limit of 100 fmol (1 µL injection volume) and 100 nmol L−1, respectively, indicate the capability of this method to become an add-on tool for quantification of organic compounds such as alcohols, amines, acids or ketones, which are routinely analysed with gas chromatographic techniques.
A Catalyst-Free Growth of ZnO Nanowires on Si (100) Substrates: Effect of Substrate Position on Morphological, Structural and Optical Properties (2012)

An investigation into the catalyst-free growth of highly crystalline zinc oxide nanowires from metallic zinc powder on Si (100) substrate was investigated through the vapor solid (VS) process at 900°C in a tube furnace. The effect of substrate position on the morphology, structure and photoluminescence (PL) properties of the fabricated ZnO nanowires was evaluated. The diameter of the resulted nanowires varies from 50 nm to 300 nm upon increasing the separation distance, between the substrate and the Zn powder source, from 12 cm to 16 cm. The EDX and XRD results showed that the zinc to oxygen ratio and the crystallinity of the fabricated nanowires are dependent on the substrate position. Also, the ratio of the UV to visible emission peaks of the fabricated ZnO nanowires was found to be strongly dependent on the substrate position. The PL spectra showed the enhancement in UV emissions for the samples fabricated on the substrate farther away from the Zn source with enhanced near band-edge emission for thicker nanowires. A possible mechanism for the growth of ZnO nanowires is discussed.