gebhart/patrepeval huggingface dataset:
Emphasis of spatial cues in the temporal fine structure during the rising segments of amplitude-modulated sounds (2013)

The ability to locate the direction of a target sound in a background of competing sources is critical to the survival of many species and important for human communication. Nevertheless, brain mechanisms that provide for such accurate localization abilities remain poorly understood. In particular, it remains unclear how the auditory brain is able to extract reliable spatial information directly from the source when competing sounds and reflections dominate all but the earliest moments of the sound wave reaching each ear. We developed a stimulus mimicking the mutual relationship of sound amplitude and binaural cues, characteristic to reverberant speech. This stimulus, named amplitude modulated binaural beat, allows for a parametric and isolated change of modulation frequency and phase relations. Employing magnetoencephalography and psychoacoustics it is demonstrated that the auditory brain uses binaural information in the stimulus fine structure only during the rising portion of each modulation cycle, rendering spatial information recoverable in an otherwise unlocalizable sound. The data suggest that amplitude modulation provides a means of "glimpsing" low-frequency spatial cues in a manner that benefits listening in noisy or reverberant environments.
Study on special wrought Mg-alloys (Report 1) (1956)

Recrystallization and aging phenomena of Mg-R. E. alloy extrusions were studied, and the results obtained were as follows:(1) Tensile properties of Mg-R. E. extrusions were lower than that of ordinary Mg-alloy extrusions (Mg-Al-Zn, Mg-Mn etc.) at room temperature.(2) Difference of tensile properties of Mg-R. E. extrusions according to the position in specimen taken, was larger than those of ordinary Mg-alloy extrusions.(3) The grain growth of Mg-R. E. extrusions by heating was less than that of ordinary Mg alloys. For example, the grain size of AZ 61 was growing markedly by heating over 350°C but that of Mg-R. E. alloy was gradually growing under the same condition.(4) Mg-R. E. alloy showed two step age-hardening, and its temperature range was from 100°C to 200°C. Maximum hardness was obtained by the treatment described as follows: Solution heat treatment was 550°C×20hr, and precipitation heat treatment was 150°C×12hr but in the industrial case it was suitable that solution heat treatment was 550°C×16hr and precipitation heat treatment was 200°C×16hr.
Archises - nouvelle architecture pour la création de services à valeur ajoutée (2004)

National audience
High-power, repetitive-stacked Blumlein pulsers commutated by a single switching element (1998)

The stacked Blumlein pulse generators developed at the University of Texas at Dallas consist of several triaxial Blumleins stacked in series at one end. The lines are charged in parallel and synchronously commutated with a single switching element at the other end, In this may, relatively low charging voltages are multiplied to give a higher desired voltage across an arbitrary load. Extensive characterization of the stacked Blumlein pulsers indicates that these devices are capable of producing high-power pulses with rise times and repetition rates in the range of 0.3-50 ns and 1-300 Hz, respectively, using a conventional thyratron, spark gap, or photoconductive switch. This paper presents the progress in the development and use of these novel pulsers. Recent adaptation of the design has enabled the stacked Blumlein to produce 50-70 MW nanosecond pulses with risetimes on the order of 200-300 ps into nominally matched loads. The device has a compact line geometry and is commutated by a single photoconductive switch triggered by a low power laser diode.
Interleukin-1 Stimulates ADAM17 through a Mechanism Independent of its Cytoplasmic Domain or Phosphorylation at Threonine 735 (2012)

ADAM17 (a disintegrin and metalloproteinase) is a membrane-anchored metalloproteinase that regulates the release of EGFR-ligands, TNFα and other membrane proteins from cells. ADAM17 can be rapidly activated by a variety of signaling pathways, yet little is known about the underlying mechanism. Several studies have demonstrated that the cytoplasmic domain of ADAM17 is not required for its rapid activation by a variety of stimuli, including phorbol esters, tyrosine kinases and some G-protein coupled receptors. However, phosphorylation of cytoplasmic residue T735 was recently reported as a crucial step for activation of ADAM17 by IL-1β and by the p38 MAP-kinase pathway. One possible mechanism to reconcile these results would be that T735 has an inhibitory role and that it must be phosphorylated as a pre-requisite for the activation of ADAM17, which would then proceed via a mechanism that is independent of its cytoplasmic domain. To test this hypothesis, we performed rescue experiments of Adam17-/- cells with wild type and mutant forms of ADAM17. However, these experiments showed that an inactivating mutation (T735A) or an activating mutation (T735D) of cytoplasmic residue T735 or the removal of the cytoplasmic domain of ADAM17 did not significantly affect the stimulation of ADAM17 by IL-1β or by activation of MAP-kinase with anisomycin. Moreover, we found that the MAP-kinase inhibitor SB203580 blocked activation of cytoplasmic tail-deficient ADAM17 and of the T735A mutant by IL-1β or by anisomycin, providing further support for a model in which the activation mechanism of ADAM17 does not rely on its cytoplasmic domain or phosphorylation of T735.
Lyman-α revisited (1986)

The cross-section for excitation of Lyman- alpha radiation following electron impact of H2 has been measured at 100 eV incident energy. The data were made absolute by comparison with the signal obtained from electron impact on H at the same energy making use of the Long, Cox and Smith value (1968) for this cross-section. Identical excitation and detection geometries were used, thus automatically removing many possible sources of systematic error. The value obtained, 7.13+or-0.59*10-18 cm2, is 42% lower than the earlier measurement of Mumma and Zipf (1971) and is in good agreement with very recent measurements obtained using less direct calibration techniques. The accuracy of the present measurement is a considerable improvement over most previous measurements.
Efficiency of radial-flow turbine of Turbo Engineering Corporation TT13-18 turbosupercharger (1948)

Memorandum presenting an investigation of the radial-flow turbine of the Turbo Engineering Corporation TT13-18 turbosupercharger made to evaluate the effects of inlet total pressure, inlet total temperature, and pressure ratio on the adiabatic efficiency. The results are presented by three efficiency parameters. Maximum efficiency obtained, based on total-pressure ratio and corrected for bearing friction, was 0.82 at an inlet total pressure of 50 inches of mercury absolute, an inlet total temperature of 1600 degrees R, a total-pressure ratio of 1.46, and a blade-jet speed ratio of 0.62.
Binding and Uptake of <sup>125</sup>Iodine-Labelled, Oxidized Low Density Lipoprotein by Macrophages: Comparism of the Effects of a-Tocopherol, Probucol, Pyridoxal-5'-phosphate and Magnesium-pyridoxal-5'-phosphate-glutamate (1997)

Specific and unspecific binding and uptake (internalization) by macrophages of 125iodine-labelled, copper-oxidized human low density lipoprotein is differently influenced by the anti-oxidants alpha-tocopherol (alpha-Toc), probucol (Prob), pyridoxal-5'-phosphate (PP) and the magnesium-pyridoxal-5'-phosphate glutamate complex (MPPG). Binding as well as internalization, mediated by the so-called "scavenger receptor" is lower in the presence of MPPG whereas both specific binding and internalization are enhanced. The comparison of the effects in vitro allows a rating of the potentially anti-atherogenic and thus protective effects of the tested substances as follows: MPPG > PP > alpha-Toc > Prob.
Heat Transfer in the New Millennium: Views by Members of the ASME Heat Transfer Division (2000)

The aim of this study is to evaluate the treatment outcomes and identify factors associated with adverse tuberculosis treatment outcomes for bacteriologically confirmed pulmonary tuberculosis. Treatment outcomes of pulmonary tuberculosis were evaluated retrospectively among 11,186 smear- and/or culture-positive patients treated between 2006 and 2009 in Istanbul, Turkey. Adverse treatment outcomes were identified in 1,010 (9.0%) patients including death (1.8%), treatment default (6.1%), and treatment failure (1.1%). Factors associated with adverse treatment outcomes included being born abroad (odds ratios [OR], 5.38; 95% confidence intervals [CI], 3.67-7.91), history of tuberculosis treatment (OR, 3.77; 95% CI, 3.26-4.36), age > 65 years (OR, 2.79; 95% CI, 2.21-3.53), and male gender (OR, 1.91; 95% CI, 1.59-2.27). Death was most strongly associated with age > 65 years (OR, 45.1; 95% CI, 27.0-75.6), followed by treatment default with history of interrupted treatment (OR, 11.6; 95% CI, 8.94-15.1), and treatment failure with prior history of treatment failure (OR, 17.1; 95% CI, 6.97-41.6). Multidrug resistance was strongly associated with adverse treatment outcomes (OR, 10.8; 95% CI, 8.02-14.6). Age > 65 years, male sex, being born abroad, and history of treatment failure were found to be risk factors for adverse treatment outcomes. Hence, patients with any of these characteristics should be carefully monitored and treated aggressively.
Effects of increases in dietary fat intake on plasma lipid and lipoprotein cholesterol concentrations and associated enzyme activities in cats (2011)

Diets containing up to 66% of energy from fat were tolerated well by healthy cats and did not affect plasma lipid concentrations. Therefore, high-fat diets probably will not contribute to hypercholesterolemia or hypertriglyceridemia in cats.
A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis (2000)

The Saccharomyces cerevisiae Rlp7 protein has extensive identity and similarity to the large ribosomal subunit L7 proteins and shares an RNA-binding domain with them. Rlp7p is not a ribosomal protein; however, it is encoded by an essential gene and therefore must perform a function essential for cell growth. In this report, we show that Rlp7p is a nucleolar protein that plays a critical role in processing of precursors to the large ribosomal subunit RNAs. Pulse-chase labeling experiments with Rlp7p-depleted cells reveal that neither 5.8S(S), 5.8S(L), nor 25S is produced, indicating that both the major and minor processing pathways are affected. Analysis of processing intermediates by primer extension indicates that Rlp7p-depleted cells accumulate the 27SA(3) precursor RNA, which is normally the major substrate (85%) used to produce the 5.8S and 25S rRNAs, and the ratio of 27SB(L) to 27SB(S) precursors changes from approximately 1:8 to 8:1 (depleted cells). Because 27SA(3) is the direct precursor to 27SB(S), we conclude that Rlp7p is specifically required for the 5' to 3' exonucleolytic trimming of the 27SA(3) into the 27SB(S) precursor. As it is essential for processing in both the major and minor pathways, we propose that Rlp7p may act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs. Rlp7p may also be required for the endonucleolytic cleavage in internal transcribed spacer 2 that separates the 5.8S rRNA from the 25S rRNA.
Patients With Epilepsy Who Die Suddenly Have Cardiac Disease (1998)

Our results support the hypothesis that patients with epilepsy who die suddenly and unexpectedly have cardiac pathologic conditions that may be responsible for their deaths.
CYP2D6 polymorphism is not crucial for the disposition of selegiline* (1998)

CYP2D6 is not important in the primary elimination of selegiline, and the biological effect of selegiline seems to be similar in poor metabolizers and extensive metabolizers of debrisoquin. The inhibitory effect of selegiline and its main metabolites on CYP2D6 activity seems to be negligible.
Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming (2015)

Werner syndrome (WS) is a rare human autosomal recessive premature aging disorder characterized by early onset of aging-associated diseases, chromosomal instability, and cancer predisposition. The function of the DNA helicase encoded by WRN, the gene responsible for WS, has been studied extensively. WRN helicase is involved in the maintenance of chromosome integrity through DNA replication, repair, and recombination by interacting with a variety of proteins associated with DNA repair and telomere maintenance. The accelerated aging associated with WS is reportedly caused by telomere dysfunction, and the underlying mechanism of the disease is yet to be elucidated. Although it was reported that the life expectancy for patients with WS has improved over the last two decades, definitive therapy for these patients has not seen much development. Severe symptoms of the disease, such as leg ulcers, cause a significant decline in the quality of life in patients with WS. Therefore, the establishment of new therapeutic strategies for the disease is of utmost importance. Induced pluripotent stem cells (iPSCs) can be established by the introduction of several pluripotency genes, including Oct3/4, Sox2, Klf4, and c-myc into differentiated cells. iPSCs have the potential to differentiate into a variety of cell types that constitute the human body, and possess infinite proliferative capacity. Recent studies have reported the generation of iPSCs from the cells of patients with WS, and they have concluded that reprogramming represses premature senescence phenotypes in these cells. In this review, we summarize the findings of WS patient-specific iPSCs (WS iPSCs) and focus on the roles of telomere and telomerase in the maintenance of these cells. Finally, we discuss the potential use of WS iPSCs for clinical applications.
The Low Temperature Catalyzed Chemical Vapor Deposition and Characterization of Silicon Nitride Thin Films (1992)

Silicon nitride thin films have been grown via low pressure chemical vapor deposition at substrate temperatures ranging from 662 to 904 K by the catalytic action of a heated tungsten filament. A tungsten filament heated to 2020 K was used to decompose ammonia, which reacted with silane introduced downstream of the filament to form silicon nitride films at deposition rates between 50 and 250 nm/min. The resultant films were characterized by Fourier‐transform infrared spectroscopy, x‐ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and spectroscopic ellipsometry (SE). Infrared spectroscopy indicated that, under appropriate deposition conditions, the amount of bonded hydrogen in the films could be reduced to less than 3%. XPS sputter depth profiles showed that the level of oxygen in the films decreased as the silane flow rate was increased. Oxygen free silicon nitride films were obtained at high silane flow rates. XPS and SE were used to profile the films and to establish the thickness and composition of the bulk, surface, and interfacial layers. SEM confirmed the specular nature of the deposited silicon nitride films.
Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components (1997)

In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor necrosis factor alpha independent and required the presence of monocytes and plasma. Since IL-6 can stimulate replication of the human immunodeficiency virus in monocytic cells, these findings may be clinically relevant.
Synthesis and Application of a Fluorous Lawesson′s Reagent: Convenient Chromatography‐Free Product Purification. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Complexes Derived from Strong Field Ligands. XIV. Heterometallic Trinuclear Complexes of β-Mercaptoethylamine (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplexes Derived from Strong Field Ligands. XIV. Heterometallic Trinuclear Complexes of β-MercaptoethylamineDonald C. Jicha and Daryle H. BuschCite this: Inorg. Chem. 1962, 1, 4, 878–883Publication Date (Print):November 1, 1962Publication History Published online1 May 2002Published inissue 1 November 1962https://pubs.acs.org/doi/10.1021/ic50004a035https://doi.org/10.1021/ic50004a035research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins (1990)

A human sialophorin (CD43) specific genomic clone was isolated, and a 6.5 kb fragment containing the 4.6 kb sialophorin gene was sequenced. The promoter region contains no TATA or CAAT boxes, but is highly enriched in G and C nucleotides and contains short repeat sequences similar to those found in the promoters of 'housekeeping' genes. S1-nuclease protection and primer-extension experiments established that the sialophorin gene has two major transcription initiation sites. There is a single intron of 378 bp that interrupts the sequence specifying the mRNA 5' untranslated region. The gene is therefore unusual in that the discrete extracellular, transmembrane and intracellular regions of the protein, including repeat sequences in the extracellular region, are not encoded by separate exons. Utilization of alternative polyadenylation signals was previously shown to generate two sialophorin mRNAs of 1.9 and 4.3 kb, which differ in the length of their 3' untranslated regions. Sequence analysis of the gene establishes that a single polyadenylation signal 2301 bp downstream of the first major transcription initiation site and five overlapping polyadenylation signals beginning a further 2290 bp downstream define the 3' termini of the 1.9 and 4.3 kb mRNA species respectively. The gene contains potential Z-DNA structures, Aly sequences, and elements that may be involved in regulating mRNA stability.
A computationally efficient wavelet transform CELP coder (2002)

A wavelet-transform-based CELP coder design is presented in this paper for high-quality speech coding at about 4.8 kbits/s. The coder quantizes the second residual using a wavelet transform approach instead of the stochastic-codebook-based vector quantization normally used in CELP coders, including the U.S. Federal Standard FS 1016 coder at 4.8 kbits/s. The wavelet coder improves the computational efficiency for encoding the second residual by requiring only 1.2 MIPS instead of 8.3 MIPS required by FS 1016. Subjective speech quality tests involving pairwise comparisons show that the wavelet coder was preferred 61% of the time over FS 1016.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Role of Btg2 in the Progression of a PDGF-Induced Oligodendroglioma Model (2012)

Tumor progression is a key aspect in oncology. Not even the overexpression of a powerful oncogenic stimulus such as platelet derived growth factor-B (PDGF-B) is sufficient per se to confer full malignancy to cells. In previous studies we showed that neural progenitors overexpressing PDGF-B need to undergo progression to acquire the capability to give rise to secondary tumor following transplant. By comparing the expression profile of PDGF-expressing cells before and after progression, we found that progressed tumors consistently downregulate the expression of the antiproliferative gene Btg2. We therefore tested whether the downregulation of Btg2 is sufficient and necessary for glioma progression with loss and gain of function experiments. Our results show that downregulation of Btg2 is not sufficient but is necessary for tumor progression since the re-introduction of Btg2 in fully progressed tumors dramatically impairs their gliomagenic potential. These results suggest an important role of Btg2 in glioma progression. Accordingly with this view, the analysis of public datasets of human gliomas showed that reduced level of Btg2 expression correlates with a significantly worse prognosis.
Regulation of cell proliferation by Smad proteins (2002)

Transforming growth factor-beta (TGF-beta) family members which include TGF-betas, activins, and bone morphogenetic proteins (BMPs) regulate a broad spectrum of biological responses on a large variety of cell types. TGF-beta family members initiate their cellular responses by binding to distinct receptors with intrinsic serine/threonine kinase activity and activation of specific downstream intracellular effectors termed Smad proteins. Smads relay the signal from the cell membrane to the nucleus, where they affect the transcription of target genes. Smad activation, subcellular distribution, and stability have been found to be intricately regulated and a broad array of transcription factors have been identified as Smad partners. Important activities of TGF-beta are its potent anti-mitogenic and pro-apoptotic effects that, at least in part, are mediated via Smad proteins. Escape from TGF-beta/Smad-induced growth inhibition and apoptosis is frequently observed in tumors. Certain Smads have been found to be mutated in specific types of cancer and gene ablation of particular Smads in mice has revealed increased rate of tumorigenesis. In late stage tumors, TGF-beta has been shown to function as a tumor promoter. TGF-beta can stimulate the de-differentiation of epithelial cells to malignant invasive and metastatic fibroblastic cells. Interestingly, TGF-beta may mediate these effects directly on tumor cells via subverted Smad-dependent and/or Smad-independent pathways.