gebhart/patrepeval huggingface dataset:
Cytochromes P450: structure, function and mechanism. (1996)

Part 1 Introduction: historical background isolation, purification and characterization spectral and related physiochemical properties substrate-binding spectra polarized optical spectroscopy vibrational spectroscopy magnetic resonance spectroscopy Mossbauer spectroscopy EXAFS spectroscopy other physical methods x-ray crystallography redox potentials and their equilibria other physiochemical and structural studies. Part 2 Evolution of the P450 superfamily: the P450 phylogenetic tree evolutionary aspects of P450 function conclusion P450 nomenclature. Part 3 The P450 catalytic cycle: the P450 catalytic cycle nature of the oxygenating species participation of active site amino acids in P450 oxygenations thermodynamics of P450 substrate binding and spin state equilibrium the coupling of redox and spin equilibria redox potential and redox interactions in the P450 system interactions between redox components protein-lipid interactions in the P450 system a proposed mechanistic scheme for the P450 catalytic cycle. Part 4 P450 substrate specificity and metabolism: endogenous metabolism exogenous metabolism the CYP1 family the CYP2 family the CYP3 family exogenous metabolism by other CYP enzymes. Part 5 Induction, regulation and inhibition: induction and regulation of P450 genes regulatory elements in P450 genes the toxic consequences of induction heterologous expression systems and in vitro models inhibition of cytochrome P450 competitive inhibitors irreversible and mechanism-based inhibitors therapeutic and agrochemical uses of P450 inhibitors metal ions as P450 inhibitors. Part 6 Structural models of P450s and related topics: P450 modelling physical methods P450 sequence alignment general features of P450 crystal structures and sequences recommended procedure for homology modelling of P450s eukaryotic P450s modelled from P450 BM3 (CYP 102) evaluation of P450-mediated toxicity by the COMPACT approach conclusions and future prospects.
An Apgar Score for Surgery (2006)

A simple score based on blood loss, heart rate, and blood pressure can be useful in rating the condition of patients after general or vascular operations.
Makower, Helen (Born 1910) (1987)

Helen Makower was educated at Cambridge and obtained her doctorate from London University. From 1938 until her retirement in 1973 she taught at the London School of Economics and Political Science. In collaboration with Jacob Marschak she made a pioneering contribution to modern asset portfolio theory and to the study of labour mobility. After World War II her analytical insights and interest in work then being performed at the Cowles Commission in Chicago led to her being one of the important links through which such techniques as activity analysis entered the academic scene in Britain. Her 1957 book and other papers made original contributions to the application of linear methods in economic analysis. One of her important insights was into the analogy between production and consumption, a precursor of later work on the household production and characteristics approaches to consumer theory.
C-reactive protein response in open fractures of the tibia (2010)

Background: C-reactive protein (CRP) is an acute-phase protein secreted by hepatocytes during various types of tissue injury. We tried to determine whether the severity of an open fracture of the tibial diaphysis as classified according to the Gustilo-Anderson system corresponds to the degree and pattern of CRP response after trauma and infection. Methods: This was a prospective study done over a six-month period on 48 patients with open tibial-diaphyseal fracture. Serial blood samples for CRP testing were taken seven times over a two-week period. The fractures were graded according to the Gustilo-Anderson classification and after surgery wounds were examined regularly for signs of surgical-site infection (SSI). Results:
380. The dependence of optical rotatory power on chemical constitution. Part XLI (1950)

M. P. Balfe, J. Chem. Soc., 1950, 1871 DOI: 10.1039/JR9500001871
Factors That Influence the Localization of Sound in the Vertical Plane (1968)

The ability of listeners to locate sound in the vertical plane was investigated. The results showed that for auditory stimuli to be located accurately (1) the stimulus must be complex, (2) it must include frequencies above 7000 cps, and, (3) the pinna must be present.
Superoxide dismutase in the anal gills of the mosquito larvae of<i>Aedes aegypti</i>: Its inhibition by α‐terthienyl (1991)

The anal gills of the mosquito larvae of Aedes aegypti were shown to possess superoxide dismutase (EC 1.15.1.1) activity, which increased with the maturation of the larvae from instar 1 to instar 4. This enzyme was highly inhibited upon treatment of the larvae with alpha-terthienyl (2,2':5,2"-terthiophene) and subsequent exposure to long-wave ultraviolet light. Inhibition also occurred with treatment of the crude enzyme extract in a similar fashion. Exposure of the enzyme to the ultraviolet light alone or the treatment of the enzyme with alpha-terthienyl in darkness could not manifest this inhibition. This finding adds a new dimension to the complex mechanism(s) proposed for the photodynamic toxicity of alpha-terthienyl.
Perceptually inspired gamut mapping between any gamuts with any intersection (2015)

Comunicació presentada a la AIC 2015 Tokyo Midterm Meeting, celebrada a Tòquio (Japó) del 19 a 22 de maig de 2015.
Dendritic Cell Protocols (2001)

It is now apparent that dendritic cells not only play important roles in the body's immune system through their complex interactions with T cells, B cells, and other cell types, but also possess distinct functional attributes that enable them to assume different roles in that system. In Dendritic Cell Protocols, Stephen P. Robinson, MD, PhD, and Andrew Stagg, PhD, have brought together a wide range of time-proven methods for studying these so-called "veiled" cells. Many of these readily reproducible techniques deal with the problem of obtaining sufficient dendritic cells for analysis, whether by isolation from a wide variety of tissues or from various progenitor cell populations. Other methods describe in step-by-step fashion the techniques commonly used for analyzing aspects of dendritic cells, ranging from cell migration to antigen uptake and T cell stimulation. Variant methods that have been successful in other laboratories have been included to expand experimental possibilities. In addition, a few techniques explore the practical challenges involved in using dendritic cells in a clinical setting to develop novel immunotherapeutics. State-of-the-art and highly practical, Dendritic Cell Protocols provides both experienced and novice investigators with powerful tools to illuminate the complex biology of these foundation cells-cells that shape the evolution of acquired immune responses, play important roles in innate immunity, and promise the development of powerful new immunotherapeutics
Notes An inversion truncating the <i>creA</i> gene of <i>Aspergillus niduians</i> results in carbon catabolite derepression (1990)

The creAd-30 mutation leading to carbon catabolite derepression in Aspergillus nidulans is a pericentric inversion, having one breakpoint within the creA gene on the left arm of chromosome I and the other breakpoint between binG and yA on the right arm. The left-arm breakpoint alters the creA transcript. The likelihood that the inversion truncates creA centrally strengthens a previous proposal that derepression is the phenotype of loss-of-function mutations in creA.
Why I Chose Computer Science? Women in India (2009)

In many developed countries like the United States, the percentage of women earning a bachelorâs degree in computer science (CS) is relatively low. In contrast, in many developing countries like India there has been a significant increase in the number of women pursuing a bachelorâs degree in CS. This is despite the prevalence of patriarchy in India. This paper uncovers why women in India are attracted to CS education. It is based on 60 in-depth interviews conducted with female students majoring in CS at four institutions of higher education in India in 2007-08. The findings suggest that Indian women perceive CS as a woman-friendly field.
Grid integration of a large offshore wind farm using VSC-HVDC in parallel with an AC submarine cable (2009)

The use of a voltage source converter high voltage DC (VSC-HVDC) transmission system in parallel with an AC submarine cable to connect a large offshore wind farm to the grid is discussed. The main objective of such connection is to address the reliability issues of the point-to-point VSC-HVDC transmission scheme in the event of AC and DC faults. Control system design is described in detail and the performance of this arrangement is explored under different fault conditions. The study was conducted in Simulink.
Intrafamily distribution of green leafy vegetables. (2009)

Leafy vegetables provide much needed micronutrients (vitamins and minerals), in addition to various nutraceuticals and bioactive compounds. The present study was conducted on 100 households each of employed and unemployed groups. Questionnaire method was employed to elicit information from the respondents. The findings revealed that 24.5 percent of respondents liked greens, one hundred percent utilized mint, coriander and curry leaves irrespective of their occupation status. Fifty one per cent of the respondents consumed greens twice a week. Only 10 per cent stored greens in polythene bags with refrigeration for more than a day. Thirty eight percent included greens during pregnancy, while 42 per cent included shepu leaves (Peucedonum graveolens) during lactation. Per capita consumption of greens ranged between 48 – 66g by adults and adolescents. Thus, consumption of greens through nutrition education may be advocated to combat micronutrient malnutrition among the vulnerable section of the population.
Are responses to therapy of metastasized malignant melanoma reflected by decreasing serum values of S100β or melanoma inhibitory activity (MIA)? (2001)

In metastatic melanoma S100beta as well as melanoma inhibitory activity (MIA) are elevated in the serum in the majority of patients. Elevation has been found to correlate with shorter survival, and changes in these parameters in the serum during therapy were recently reported to predict therapeutic outcome in advanced disease. However, the value of these markers with respect to other possible markers by multivariate analysis has not yet been proven for individual patients. In this prospective study, S100beta and MIA were measured in the serum of 67 consecutive patients before and following treatment. Analysing both the sensitivity and the specificity of the serum parameters by the areas under the receiver operating characteristics (ROC) curves, decreases in S100beta and MIA during therapy were associated with response to therapy, while increases indicated progressive disease. Unexpectedly, the individual diagnostic value of changes in tumour markers during therapy was not superior to one-point measurements at restaging. Moreover, S100beta and MIA were not superior to the conventional parameters lactate dehydrogenase and C-reactive protein (CRP) on multiple logistic regression analysis. Applying classification and regression trees (CARTs), one-point measurements of CRP was shown to be the most relevant overall parameter.
Abdominal obesity: the most prevalent cause of the metabolic syndrome and related cardiometabolic risk (2006)

Abdominal obesity, due to intra-abdominal adiposity, drives the progression of multiple cardiometabolic risk factors independently of body mass index. This occurs both through altered secretion of adipocyte-derived biologically active substances (adipokines), including free fatty acids, adiponectin, interleukin-6, tumour necrosis factor alpha, and plasminogen activator inhibitor-1, and through exacerbation of insulin resistance and associated cardiometabolic risk factors. The prevalence of abdominal obesity is increasing in western populations, due to a combination of low physical activity and high-energy diets, and also in developing countries, where it is associated with the urbanization of populations. The measurement of waist circumference, together with an additional comorbidity, readily identifies the presence of increased cardiometabolic risk associated with abdominal obesity. For example, .80% men with waist circumference 90 cm and triglycerides (TG) 2 mmol/L were found to have an atherogenic triad of elevated apolipoprotein B, fasting hyperinsulinaemia, and small, dense LDL, which had been strongly associated with adverse cardiovascular outcomes in a previous observational study. Accordingly, measurement of waist circumference should become a standard component of cardiovascular risk evaluation in routine clinical practice. Lifestyle modification remains the initial intervention of choice for this population, with pharmacological modulation of risk factors where this is insufficiently effective. Looking ahead, the initial results of randomized trials with rimonabant, the first CB 1 receptor blocker, indicate the potential of correcting overactivation of the endogenous endocannabinoid system for simultaneous improvement of multiple cardiometabolic risk factors.
When Is the Classroom Assignment Problem Hard? (1992)

The classroom assignment (or hotel room or interval scheduling) problem is to assign classes, which meet at different time intervals, to rooms. Two classes may not meet simultaneously in the same room, nor may a class meet in two different rooms. Thousands of colleges and secondary schools face this problem every semester. There has been some confusion as to how hard this problem is. Many colleges claim that it is easy, while others complain that it is next to impossible. In the literature, some authors claim or conjecture polynomial time algorithms, while others develop heuristic approaches. The goal of this paper is to resolve the confusion by identifying cases where the problem will be easy and others where it will be hard. We focus on the kinds of cases that schedulers are apt to encounter in practice.
Average Gene Length Is Highly Conserved in Prokaryotes and Eukaryotes and Diverges Only Between the Two Kingdoms (2006)

The average length of genes in a eukaryote is larger than in a prokaryote, implying that evolution of complexity is related to change of gene lengths. Here, we show that although the average lengths of genes in prokaryotes and eukaryotes are much different, the average lengths of genes are highly conserved within either of the two kingdoms. This suggests that natural selection has clearly set a strong limitation on gene elongation within the kingdom. Furthermore, the average gene size adds another distinct characteristic for the discrimination between the two kingdoms of organisms.
X-ray fluorescence control of the gadolinium contents of plastic scintillators based on poly(methylmethacrylate) (1987)

The possibility of preparing synthetic standard samples for nondestructive x-ray fluorescence determination of gadolinium in poly(methylmethacrylate) has been demonstrated. A study has been made of the effect of surface roughness of the emitter on the results of the analysis.
Gotik (2013)

In der Mitte des 12. Jahrhunderts gab der Abt des französischen Klosters Saint-Denis den Neubau seiner Abteikirche in Auftrag. Dieser Baumaßnahme lag ein völlig neues Konzept zugrunde, das Elemente wie Spitzbogen, große Buntglasfenster, hohe Steingewölbe und Strebepfeiler vereinte. Dieser neue Baustil war derart wirkungsvoll, dass er sich über den gesamten europäischen Raum verbreitete und hier die Architektur mehr als 300 Jahre lang dominierte. Die Zeit der Gotik hatte begonnen.
Fourier analysis and structure determination. Part II. Pulse NMR and NMR imaging (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFourier analysis and structure determination. Part II. Pulse NMR and NMR imagingJohn P. Chesick Cite this: J. Chem. Educ. 1989, 66, 4, 283Publication Date (Print):April 1, 1989Publication History Received3 August 2009Published online1 April 1989Published inissue 1 April 1989https://doi.org/10.1021/ed066p283RIGHTS & PERMISSIONSArticle Views296Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (5 MB) Get e-Alerts Get e-Alerts
Analisis Kecerdasan Emosi dan Manajemen Konflik (2017)

This study aims to determine the level of emotional intelligence of students, To know the picture perindenter kecerdaan emotions of students, To know the level of conflict management students who have on him, To know the picture of student conflict management indicators. The sample in this research is all students of SMP class VIII which amounted to 134 people. The result of this research is the emotional intelligence of students in general is in the high category with the percentage of 76.9%, then in the middle category with the percentage of 14.2%, and then in very high category with the percentage of 8.9%, students' emotional intelligence per-indicator of the most Students are selected on the indicators of managing self-emotion, and the least are indicators of recognizing self-emotion. The average student conflict management strategy lies in a compromise strategy.
Benzylation and Related Alkylations of α-Dimethylaminophenylacetonitrile by Means of Alkali Amides. Dehydrocyanation of Products to Form Enamines<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzylation and Related Alkylations of α-Dimethylaminophenylacetonitrile by Means of Alkali Amides. Dehydrocyanation of Products to Form Enamines1Charles R. Hauser, Harold M. Taylor, and T. Glen LedfordCite this: J. Am. Chem. Soc. 1960, 82, 7, 1786–1789Publication Date (Print):April 1, 1960Publication History Published online1 May 2002Published inissue 1 April 1960https://pubs.acs.org/doi/10.1021/ja01492a059https://doi.org/10.1021/ja01492a059research-articleACS PublicationsRequest reuse permissionsArticle Views308Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Investigation of ultra-thin gate oxide reliability behavior by separate characterization of soft breakdown and hard breakdown (2002)

It is shown in this work that the soft breakdown can follow a significantly different temperature and field acceleration behavior than the dielectric breakdown (hard breakdown). These properties have a strong influence on reliability prediction of ultra-thin oxides and can result in misinterpretation if soft breakdown and hard breakdown events are mixed up during gate oxide reliability testing. The activation energy and the field acceleration of the soft breakdown are compared to the disturbed-bond breakage process proposed in the thermochemical E-model. It is concluded that soft breakdown can be caused by H-Si and H-O bond breakage due to the electric field in the oxide. The activation energy for soft breakdown also indicates that formation of a soft breakdown path is influenced by hydrogen diffusion in the oxide.
Efficacy of marinades against Listeria monocytogenes cells in suspension or associated with green shell mussels (Perna canaliculus) (1995)

In order to determine the listericidal efficacies of three marinades used in the production of marinated green shell mussels (Perna canaliculus), decimal reduction times (D values) were determined for a mixture of seven strains of Listeria monocytogenes exposed to marinades in the presence and absence of mussels. With an acetic acid (1.5%, wt/vol) marinade, calculated D values in the presence and absence of mussels were 77.3 and 33.3 h, respectively. Likewise, for an acetic acid (0.75%)-lactic acid (0.75%) marinade and an acetic acid (1.5%)-Glucono Delta-Lactone (0.2%)-based marinade, the D values in the presence and absence of mussels were 125.5 and 26.9 h and 86.3 and 19.3 h, respectively. Various increases in decimal reduction times in the presence of mussels indicated that there was no simple relationship between the listericidal natures of these marinades and the presence of mussels. This result suggests that difficulties may occur in trying to relate acid inhibition studies carried out in model broth systems to "real food" systems.
Monoclonal antibodies that recognize the P fimbriae F71, F72, F9, and F11 from uropathogenic Escherichia coli (1985)

The Escherichia coli P fimbriae F71, F72, F9, and F11 from four cloned strains were purified, and polyclonal antisera were raised in rabbits. Cross-reactions of these antisera with eight different cloned and purified fimbriae were measured in an enzyme-linked immunosorbent assay. These antisera showed a reaction with the homologous fimbriae and also with most heterologous fimbriae. Monoclonal antibodies (MAbs) directed against the same four native fimbriae were produced by the fusion of spleen cells from immunized BALB/c mice with SP2/0 myeloma cells. The resulting four series of MAbs were also screened in an enzyme-linked immunosorbent assay with eight different cloned and purified fimbriae. Four different F71 hybridomas produced MAbs which recognized only epitopes on F71 fimbriae. Two F72 MAbs recognized epitopes on F72 and F9 fimbriae, whereas another F72 MAb recognized an epitope on only F72 fimbriae. Three MAbs raised against F9 reacted only with epitopes on F9 fimbriae. Six MAbs against F11 fimbriae could be divided into two groups: on the one hand two MAbs recognizing F11, pyelonephritis-associated pilus, Pap, and F72 fimbriae and on the other hand four MAbs recognizing F11 and "Clegg" fimbriae. None of the MAbs reacted with 1A or 1C fimbriae. In a hemagglutination inhibition assay it was shown that none of the MAbs produced inhibited the adhesive properties of homologous cloned strains.