gebhart/patrepeval huggingface dataset:
Determination of D- and L-Amino Acids by Ion Exchange Chromatography as L-D and L-L Dipeptides (1968)

Abstract A procedure for the precise determination of the d and l isomers in a given sample of an amino acid has been based upon chromatographic separation of the diastereoisomeric dipeptides obtained by derivatization with an l-amino acid N-carboxyanhydride. The conditions for the preparation of dipeptides developed by Hirschmann and associates make the derivatization step simple and rapid; the coupling proceeds at pH 10.4 in 2 min in about 90% yield. For each of 21 individual amino acids conditions of elution have been found for the separation of the resulting pairs of l-d and l-l dipeptides by ion exchange chromatography on an amino acid analyzer. One part of d-amino acid can be detected in the presence of 1000 parts of the l isomer with 2-µmole samples. With a mixture of amino acids, a given component can be isolated chromatographically for subsequent determination of the d to l ratio or chromatographic separation of the dipeptides prepared by derivatization of the mixture can be undertaken. If the mixture is a hydrolysate of a peptide or a protein, the degree of racemization occurring during acid hydrolysis must also be considered. For this purpose hydrolysates of synthetic bradykinin and of pancreatic ribonuclease have been examined. The amounts of several d-amino acids (0.2 to 4.4%) determined in the hydrolysates were not significantly higher than those found in control experiments when the pure l-amino acids or l-l dipeptides were subjected to the hydrolytic conditions.
Contributors, June, 1967 (1967)

Contains an entry for each author and coauthor included in this issue of the publication.
III.–iii. (2008)

<sc>The</sc> seventy young women, of ages varying in the main from nineteen to one-and-twenty, though several were older, who at this date filled the species of nunnery known as the Training-School* at Melchester, formed a very mixed community which included the daughters...
Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats (2008)

Our findings show the relevance of exploring EHC in a quantitative manner to accurately interpret pharmacodynamic findings in vivo, in particular when scaling across species.
Impact of distance-dependent location dispersion error on interpretation of microseismic event distributions (2010)

Along with horizontal drilling and hydraulic fracturing technology, monitoring-induced microseismic activity during hydraulic fracturing has played a significant role in the economic development of today's prolific tight-gas and shale resource plays. Many microseismic fracture monitoring papers in the current literature discuss the equipment, how to acquire and process microseismic data, and how to determine an appropriate velocity model. Unfortunately, for an operating company's completion engineers and geophysicists charged with interpreting these data and integrating them with other data sets, only a few papers discuss the impact of artifacts and location uncertainties on the interpretation. While microseismic data have been very useful in the economic development of resource plays, there are a number of significant pitfalls and interpretational issues that, if not understood, will potentially lead to erroneous interpretations. This is especially important for any real-time decisions during a hydraulic fracture treatment.
Mechanism of Dinitrochlorobenzene-Induced Dermatitis in Mice: Role of Specific Antibodies in Pathogenesis (2009)

In striking contrast to the long-held belief that dinitrochlorobenzene-induced contact hypersensitivity is a cell-mediated immune response, the results of our present study demonstrated that the production of dinitrochlorobenzene-specific antibodies by activated B cells played an indispensible role in the pathogenesis of dinitrochlorobenzene-induced CHS. These findings may provide new possibilities in the treatment of human contact hypersensitivity conditions.
Postpartum dyspareunia. An unexplored problem. (1999)

Postpartum dyspareunia is quite common and can be a significant source of difficulty in the months after delivery. It is an underdetected problem and deserves more study.
Hierarchical matching for retrieval of hand-drawn sketches (2003)

As pen-based devices become more popular, it has motivated several novel research issues in the area of pen computing. One interesting and practical problem is the storage and retrieval of hand-drawn sketches. A sketch can consist of handwritten notes, symbols, free-form hand-drawings, annotations on a document, and others. It is very useful to store the sketches in a database and then retrieve them later. In our prior work, we proposed a method for hand-drawn sketch retrieval by performing stroke-by-stroke matching and by considering the spatial relationship between them. In this paper, we propose a method to simplify a sketch and perform matching in a hierarchical manner. With this approach, a shaded region or a region of complex strokes can be detected automatically and represented as a single hyper-stroke. In the matching stage, the similarity is computed by combining the similarity scores across the feature spaces at each level and the similarity of the stroke hierarchies. A sketch may be better represented by exploiting the structural relationship between the strokes. In addition, as a general rule to the hierarchical approach, it has the advantage of reduced computation thus the retrieval process would speed up.
Comparison of hollow fibre membranes for hepatocyte immobilisation in bioreactors. (1996)

Various hollow fibre membranes of polyamide, cellulose and polypropylene were investigated as potential substrata for hepatocyte immobilisation in bioreactors for hybrid liver support systems. Membranes were subjected to a cytocompatibility test in which the attachment and morphology of primary hepatocytes were evaluated. The effect of coating with collagen and fibronectin was also studied. Adequate cell immobilisation was possible on polypropylene and polyamide membranes even without coating. The flattening process of the cells was dependent on the material and the coating. The incorporation of porous polypropylene hollow fibres in hybrid liver cell bioreactors and their specific permeability properties could also offer means for cell oxygenation, metabolite distribution and immuno-isolation purposes.
Assessing the information environment in intensive care units (2006)

Abstract This paper describes the development and application of a methodology for evaluating how physicians and nurses view the usefulness of various sources of patient information available within a hospital intensive care unit (ICU). The methodology encompasses semi-structured interviews, task analysis, a simulated case study of a critically ill patient, verbal protocol analysis, questionnaire responses based on both past experiences in the ICU and performance on the simulated task, and a post-task interview. Eleven nurses and six physicians participated in the study. Analysis of the questionnaires revealed significant differences in the rankings of the information sources by both the nurses and the physicians on each of seven evaluation criteria. Significant differences were also found among both the physicians and the nurses in rankings of the relative importance of the individual information sources for meeting task requirements. A framework for describing information gathering applicable to critical care environments was proposed as a means for better understanding how information sources are used. Overall, the methodology was found to be useful in terms of providing valuable data regarding the utility and usability of information sources. The importance of using a systematic approach for assessing the usefulness of information sources, particularly from the perspectives of performing design interventions and predicting the effectiveness of new information technologies, as well as the limitations in adopting this type of approach, are also discussed. Acknowledgements This material is based upon work supported by the National Science Foundation under Grant No. 9619803. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily represent those of the National Science Foundation. Notes †These ratings refer to the mean of the ranks of the individual sources comprising a category.
Behavioral Disorders in Alzheimer Disease: A Transcultural Perspective (1998)

These results indicate that NPI is a reliable instrument with which to study transcultural differences in the presentation of neuropsychiatric disturbances in patients with AD. The described similar pattern of behaviors between Italians and US patients with AD suggests a biological origin of the disorders. However, cultural influences must be taken in account when the focus of the study is on psychopathological aspects of dementia.
Traceability Establishment and Visualization of Software Artefacts in DevOps Practice: A Survey (2019)

DevOps based software process has become popular with the vision of an effective collaboration between the development and operations teams that continuously integrates the frequent changes. Traceability manages the artefact consistency during a software process. This paper explores the trace-link creation and visualization between software artefacts, existing tool support, quality aspects and the applicability in a DevOps environment. As the novelty of this study, we identify the challenges that limit the traceability considerations in DevOps and suggest research directions. Our methodology consists of concept identification, state-of-practice exploration and analytical review. Despite the existing related work, there is a lack of tool support for the traceability management between heterogeneous artefacts in software development with DevOps practices. Although many existing studies have low industrial relevance, a few proprietary traceability tools have shown a high relevance. The lack of evidence of the related applications indicates the need for a generalized traceability approach. Accordingly, we conclude that the software artefact traceability is maturing and applying collaboratively in the software process. This can be extended to explore features such as artefact change impact analysis, change propagation, continuous integration to improve software development in DevOps environments.
Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profile in patients with ulcerative colitis (2012)

A distinct proteomic profile of inflamed tissue in UC patients was found. Specific proteins involved in energy metabolism and oxidative stress were identified as potential candidate markers for UC.
Pelvic Floor Spasm: The missing link in chronic pelvic pain (2012)

Acute or chronic pelvic pain is often due to musculoskeletal disorders, which may go unrecognized during a traditional pelvic examination. Proper evaluation facilitates the diagnosis of spasm or trigger points, and physical therapy often achieves a major improvement in quality of life for these women.
The Sorrows of the Prince Charming: The Tragic Life of Crown Prince Rudolf (2011)

The Crown Prince Rudolf (1858-1889) was the heir of Franz Joseph I, emperor of Austria, and his wife Elizabeth of Bavaria, the beauty of Europe. He was famous for his love affair with the then 17-year-old Baroness Mary Vetsera and their double-suicide in Mayerling. The death of the young and charming prince appalled turn-of-the-century Vienna. This paper briefly examines the life and death of the prince, which include his relationship with his family, his personal goals and pursuits, and his romantic involvement with Mary Vetsera.
Silicon sensor microsystem for ultraviolet detection (2000)

These Ecole polytechnique federale de Lausanne EPFL, n° 2152 (2000)Faculte des sciences et techniques de l'ingenieurJury: Hannes Bleuler, Marc Ilegems, Hans Melchior, Peter Seitz Public defense: 2000-4-7 Reference doi:10.5075/epfl-thesis-2152Print copy in library catalog Record created on 2005-03-16, modified on 2016-08-08
Análisis cefalométrico para la medición de cambios dentofaciales de Quirós (1998)

espanolLa Cefalometria como metodo auxiliar de diagnostico de maloclusiones y malformaciones craneofaciales es una de las herramientas mas utilizadas, su uso para la evaluacion de los resultados no ha sido tan popular debido a que la mayoria de los analisis expresan sus valores de manera angular lo que no es de facil interpretacion para el comun de los estomatologos. Este analisis permite evaluar los cambios realizados a los pacientes, expresandolos en milimetros, con mediciones faciles de realizar y de comprender, y demuestra la aplicabilidad en distintas disciplinas como Ortodoncia, Oprtopedia maxilar , Cirugia Ortognatica, medicina pediatrica etc. EnglishCephalometrics is an auxiliary diagnostic method in maloclusions and craneofacial malformations. Some of the limitations of this analisis is that uses angular mesusrements wich are difficult to interpret. This analisis allows to mesaure the changes in milimeters wich makes the mesearments easier and more aplicable to disciplines as orthodontics, dentofacial orthopedics, orthognatic surgery and pediatric medicine.
Freedom in the World's Press: A Fresh Appraisal with New Data (1965)

Analysis of experts' ranking of 117 countries on a 9-point scale from freedom to control indicates economic level is most significant factor. Comparison with earlier study shows more gains than losses in last five years.
[New antiepileptic drugs in childhood epilepsies: indications and limits]. (2001)

Regarding the antiepileptic drugs (AEDs) in children, it was recently shown that they have a specific profile of efficacy and also of worsening according to the different epilepsy syndromes. However, the therapeutic profile of the most recent compounds is still not completely established in children because of the high number of syndromes and the difficulty to perform controlled studies in this age range. Controlled studies are most often first performed in adults and they begin in children whereas the new drug is already approved. However, some new AEDs dramatically improved seizure control, particularly in some severe epilepsy syndromes such as West syndrome and Lennox-Gastaut syndrome. Vigabatrin demonstrated a remarkable efficiency in infantile spasms whereas it tends to worsen myoclonic epilepsies, absence epilepsy and idiopathic partial epilepsy. Lamotrigine is efficient in absence epilepsy and symptomatic or cryptogenic generalized epilepsies such as Lennox-Gastaut syndrome and myoclonic astatic epilepsy. By contrast, lamotrigine increases the frequency of seizures in severe myoclonic epilepsy in infancy (Dravet syndrome) as well as in some cases of idiopathic partial epilepsy. Felbamate remains indicated as third line drug in refractory Lennox-Gastaut syndrome provided blood parameters are controlled. The therapeutic profile of oxcarbazepine is closed to that of carbamazepine. The efficacy of topiramate was demonstrated in partial epilepsy, but the other indications remain to be précised. Pediatric studies using gabapentin and tiagabine disclosed encouraging results in partial epilepsy. Clinical trials with stiripentol represent an example of strategy for developing a new AED in children; it recently demonstrated, in association with clobazaru, efficacy in a severe myoclonique epilepsy in infancy.
Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy (2019)

Our data prove the utility of assessing blood levels of HCQ in the prediction of retinopathy. This would allow clinicians to either decrease the dose or increase monitoring in those patients with high HCQ blood levels.
The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair (2016)

USP1 deubiquitinating enzyme and its stoichiometric binding partner UAF1 play an essential role in promoting DNA homologous recombination (HR) repair in response to various types of DNA damaging agents. Deubiquitination of FANCD2 may be attributed to the key role of USP1-UAF1 complex in regulating HR repair, however whether USP1-UAF1 promotes HR repair independently of FANCD2 deubiquitination is not known. Here we show evidence that the USP1-UAF1 complex has a FANCD2-independent function in promoting HR repair. Proteomic search of UAF1-interacting proteins revealed that UAF1 associates with RAD51AP1, a RAD51-interacting protein implicated in HR repair. We show that UAF1 mediates the interaction between USP1 and RAD51AP1, and that depletion of USP1 or UAF1 led to a decreased stability of RAD51AP1. Protein interaction mapping analysis identified some key residues within RAD51AP1 required for interacting with the USP1-UAF1 complex. Cells expressing the UAF1 interaction-deficient mutant of RAD51AP1 show increased chromosomal aberrations in response to Mitomycin C treatment. Moreover, similar to the RAD51AP1 depleted cells, the cells expressing UAF1-interaction deficient RAD51AP1 display persistent RAD51 foci following DNA damage exposure, indicating that these factors regulate a later step during the HR repair. These data altogether suggest that the USP1-UAF1 complex promotes HR repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1.
Character strengths and virtues: a handbook and classification (2004)

The classification of strengths presented in this book is intended to reclaim the study of character and virtue as legitimate topics of psychological inquiry and informed societal discourse. By providing ways of talking about character strengths and measuring them across the life span, this classification will start to make possible a science of human strengths that goes beyond armchair philosophy and political rhetoric. We believe that good character can be cultivated, but to do so, we need conceptual and empirical tools to craft and evaluate interventions.
Precipitator Design (1977)

Abstract The various design philosophies and methods used in the engineering design of precipitators for fly ash are reviewed and assessed in light of current stringent environmental standards. The basic precipitator size and electrical parameters are individually analyzed and related to particle and flue gas properties. Actual precipitator design practice is illustrated by data for a wide cross section of power plant installations.
Cross-Domain Data Sharing in Distributed Electronic Health Record Systems (2009)

Cross-organization or cross-domain cooperation takes place from time to time in Electronic Health Record (EHR) system for necessary and high-quality patient treatment. Cautious design of delegation mechanism must be in place as a building block of cross-domain cooperation, since the cooperation inevitably involves exchanging and sharing relevant patient data that are considered highly private and confidential. The delegation mechanism grants permission to and restricts access rights of a cooperating partner. Patients are unwilling to accept the EHR system unless their health data are guaranteed proper use and disclosure, which cannot be easily achieved without cross-domain authentication and fine-grained access control. In addition, revocation of the delegated rights should be possible at any time during the cooperation. In this paper, we propose a secure EHR system, based on cryptographic constructions, to enable secure sharing of sensitive patient data during cooperation and preserve patient data privacy. Our EHR system further incorporates advanced mechanisms for fine-grained access control, and on-demand revocation, as enhancements to the basic access control offered by the delegation mechanism, and the basic revocation mechanism, respectively. The proposed EHR system is demonstrated to fulfill objectives specific to the cross-domain delegation scenario of interest.
Clinical comparison of resorbable and non‐resorbable barriers for guided periodontal tissue regeneration (1997)

The purpose of this study was to compare the clinical results of guided periodontal tissue regeneration (GPTR) using a resorbable barrier manufactured from a copolymer of polylactic and polyglycolic acids (Resolut Regenerative Material) with those of non-resorbable e-PTFE barrier (Gore-Tex Periodontal Material). 12 subjects participated, 6 with similarly paired class II furcations and 6 with 2 similar 2, 3-wall periodontal lesions. The resorbable and non-resorbable barriers were randomly assigned to 1 defect in each subject. Non-resorbable barriers were removed in six weeks. Plaque index (PlI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) and gingival recession (R) were recorded at baseline, (i.e., immediately prior to surgery) and at 12 months postsurgically. The clinical healing was similar and uneventful in both groups. Intrabony pockets depicted significant changes from baseline (p < 0.05) for probing depth reduction and gain in clinical attachment levels. No differences were found between treatments. Class II furcations showed significant improvements from baseline (p < or = 0.05) for probing depth reduction and clinical attachment gain. No differences were detected between treatments. It is concluded that the resorbable barrier tested is as effective as the nonresorbable e-PTFE barrier for the treatment of class II furcations and intrabony defects.
A Comparative Case Study of Risk, Resiliency, and Coping Among Injured National Guard (2016)

An injury during deployment disrupts family and life functioning. The purpose of the present study was to provide an in-depth examination of three injured National Guard soldiers showing how differential experiences of navigating multiple systems to obtain treatment for injury resulted in different adjustment trajectories for these soldiers and their families. A comparative case study examined three families where a soldier's injury was a central theme of family adjustment. Qualitative data were drawn from interviews conducted conjointly with both the soldier and spouse to provide an in-depth perspective of adjustment, meaning, and resource utilization patterns. In addition, survey data were collected at three time points in the deployment cycle (predeployment, 90 days post, and 1 year). These data were integrated into the case analysis, including mental health, marital relationship, treatment history, and characteristics of resilience. Study findings suggest that a delay in diagnosis, wait time for treatment, and the lack of comprehensive formal and financial support for a soldier following nonhostile injury lead to a pileup of stressors that are detrimental to the soldier's physical and mental health, financial stability, and family well-being. Further study is needed to understand how these system level issues impede resilience among National Guard families.