gebhart/patrepeval huggingface dataset:
Expression of Carbohydrate-Binding Protein p33/41 in Human Tumor Cell Lines (1996)

We previously reported a new type of lectin, p33/41 (annexin IV), which was isolated from a bovine tissue extract [Kojima, K. et al. (1992) J. Biol. Chem. 267, 20536-20539]. When the expression of p33/41 (annexin IV) was surveyed in the lysates of 39 human tumor cell lines by SDS-PAGE, followed by Western blot analysis with polyclonal anti-bovine p33/41 and monoclonal anti-annexin IV (Z016, Zymed) antibodies, 21 cell lines were found to be reactive with the polyclonal antibody, whereas all 39 cell lines were stained with Z016. These results together with those obtained with standard proteins, annexins IV and V, suggested that the monoclonal antibody, Z016, recognizes annexin V, but not p33/41 (annexin IV). Therefore, we performed cDNA cloning of human p33/41 (annexin IV) to prepare a recombinant protein and raised monoclonal antibodies against the protein. Northern blot analysis with the cDNA as a probe showed that a human colon cancer cell line, HT29, contains p33/41 (annexin IV) mRNA of two sizes, 2.0 and 3.0 kb. The two monoclonal antibodies, AS11 and AS17, against the recombinant protein generated were useful for flow cytometric analysis, ELISA, Western blot analysis and immunoprecipitation. Flow cytometric analysis with AS17 showed that p33/41 (annexin IV) is located in the cytoplasm of HT29 cells, but not on the cell surface. However, one of the cell surface proteins first labeled with biotin and then solubilized with a detergent was immunoprecipitated with AS17. The results suggest the existence of a membrane spanning form of p33/41 (annexin IV).
Mapping of Arthritogenic/Autoimmune Epitopes of Cartilage Aggrecans in Proteoglycan-Induced Arthritis (1995)

Immunization of BALB/c mice with chondroitin sulfate-depleted proteoglycan (aggrecan) of fetal human cartilage produces progressive polyarthritis and ankylosing spondylitis. The development of the disease in genetically susceptible BALB/c mice is dependent upon the expression of both cell-mediated and humoral immune responses against the host mouse cartilage proteoglycan (PG). Although cartilage PGs from various species have many biochemical and immunological similarities, only a select group of PGs from fetal and newborn human, fetal pig and canine articular cartilages, human osteophytes and human chondrosarcomas are able to induce arthritis in BALB/c mice. Arthritis develops only in mice that also develop autoantibodies to self-cartilage PGs, although autoantibodies occasionally are present in non-arthritic animals as well. The protease-sensitive auto/arthritogenic epitope(s) is located in, or close to, the chondroitin sulfate (CS) attachment region of the PG molecule. The primary structure of the core protein is responsible for the autoimmune/arthritogenic effect of this select group of PGs, whereas the core protein epitopes are masked by glycosaminoglycan (GAG)-side chains. The CS side chains seem to inhibit antigen recognition in all aggrecans with arthritogenic potential, whereas a similar effect with keratan sulfate (KS) appears only in PGs of aging cartilages.
Nondestructive Characterization of Thermal Shock and Oxidation-Induced Damage by Flash Diffusivity (2003)

The effect of thermal shock and oxidation-induced damage on the thermal diffusivity of unidirectional Nicalon-LAS glass–ceramic composites is presented in this study. The data presented show that thermal diffusivity measurements provide a sensitive nondestructive method whereby damage progression may be assessed. Samples were exposed to isothermal oxidation and thermal shock environments. In addition, combined cycles of oxidation and thermal shock were also evaluated. The thermal diffusivity transverse to the fibers was measured to detect changes in material integrity. Significant decreases up to 23% were observed in the thermal diffusivity of the material.
Straight-rays redatuming: A fast and robust alternative to wave-equation-based datuming (2006)

Abstract Wave-equation-based redatuming is expensive and requires a detailed knowledge of the shallow velocity field. We derive the analytical expression of a new prestack wavefield extrapolation operator, the Topographic Datuming Operator (TDO), which applies redatuming based on straight-rays approximation above and below a chosen datum. This redatuming operator is directly applied to common-source gathers to downward continue the source and the receivers, simultaneously, to the datum level without resorting to common-receiver gathers. As a result, the method is far more efficient and robust than the conventional wave-equation-based redatuming and does not require an accurate depth-domain interval velocity model. In addition, TDO, unlike wave-equation-based redatuming, requires effective velocities above datum, and thus can be applied using attributes valid for static correction methods. Effective velocities beneath the datum permit us to replace the surface integral, which is needed for wave-equation redatuming with a line integral. In the particular case of infinite (in practice, very high with respect to the shallow layers) velocity beneath the datum, the TDO impulse response collapses to a point, and TDO redatuming is equivalent to conventional static correction, which may, therefore, be regarded as a special case of the newly derived operator. The computational cost of applying TDO is slightly larger than static corrections, yet provides higher quality results partially attributable to the ability of TDO to suppress diffractions emanating from anomalies above datum. Since TDO is an operation based on geometrical optics approximation, velocity after TDO is not biased by the vertical shift correction associated with conventional static correction. Application to a synthetic data set demonstrates the features of the method.
The Comparative Use of Multiple Electronic Devices in the Teledermoscopic Diagnosis of Early Melanoma (2020)

<b><i>Background:</i></b> The use of mobile electronic devices as support to medical activity was largely implemented in the past decade. <b><i>Introduction:</i></b> Our first aim was to evaluate the frequency of use of different electronic devices, that is, personal computer (PC), notebook, tablet, smartphone, in a pool of dermatologists recruited to perform multiple online testing session on difficult melanocytic skin lesions (MSLs) cases. The second aim was to evaluate the feasibility of each device in terms of teledermatologic diagnostic performance; the use of four different diagnostic methods, that is, intuitive diagnosis and three dermoscopic algorithms, was also investigated. <b><i>Materials and Methods:</i></b> A total of 111 dermatologists with 4 different levels of experience in dermoscopy, performed 4 tests (intuitive diagnosis and iDScore, ABCD rule, 7-point-checklist-based diagnosis) on 979 MSLs blinded cases. Each testing session was performed with a preferred device. <b><i>Results:</i></b> The overall highest areas under the receiver operating characteristic (AUROC) (82%) was obtained by young generation dermoscopists 1-4 years experience) when using an integrated clinical dermoscopic algorithm (iDScore) on a notebook. The average dermatologist using the iDScore obtained AUROC 77.40% with large screen devices (PC and notebook) 77.6% with small screen (tablet, smartphone) and 78.2% by combining the two. <b><i>Discussion:</i></b> Young generation of dermoscopists alternately use different devices, whereas elderly generation still prefer to use the PC. The diagnostic performances obtained with small/large screen were not statistically different from those obtained with fixed/mobile devices. <b><i>Conclusions:</i></b> Mobile devices were feasible tools to achieve adequate diagnostic accuracy in difficult MSLs, on a teledermatology setting, independently from participant skill level/age.
Chilean Port Developments: Overview of the Developments in the Chilean ort Sector and the Cases of Mejillones and Bio Bio (2001)

The port of Mejillones, near Antofagasta in the northern part of Chile, is being developed by Complejo Portuario Mejillones [CPM]. The initial throughput of the new port will consist of copper, containers and general cargo. Future expansions and the provision for other commodities are foreseen in the following phases of the port master plan. An alternative design was developed for the Chilean port operator SAAM (a subsidiary of CSAV). The future port location in the Bay of Mejillones is sheltered to the south-west but open to the Pacific Ocean in north-east direction. As quite some uncertainty existed in the design wave height, a port layout was designed which would not be vulnerable to this uncertainty. After analysis of the future cargo flows it was decided to make a layout with a phased approach. Initially two berths would be constructed and at a later phase additional berths could be constructed. The tender was submitted by SAAM in July 1999.
Correction factors and sputtering effects in quantitative auger electron spectroscopy (1982)

Abstract Quantification of Auger electron spectroscopy data from silver‐gold binary alloys has been studied. It is shown that the Auger data accurately reflect the bulk composition of scribed surfaces when the intensities of elemental standards are corrected for variations in the atomic density, electron escape depth and backscatter factor. It is also shown that gold is enriched in the surface region during sputtering with either argon or neon ions but the enrichment is less when sputtered at 110 K than at 300 K. Transients are observed in the concentration of gold and silver in the surface region when the ion energy is changed from 500 eV to 2000 eV. These sputtering effects (commonly called preferred sputtering) are interpreted as resulting from a combination of recoil implantation and surface segregation.
Automatic Calibration of Geothermal Reservoir Models Through Parallel Computing on a Workstation Cluster (1999)

ITOUGH2 is an optimization code that allows estimation of any input parameter of the nonisothermal, multiphase flow simulator TOUGH2. ITOUGH2 inversions are computationally intensive because the so-called forward problem, i.e., the simulation of fluid and heat flow through the geologic formation, must be solved many times for different parameter combinations to evaluate the misfit criterion or to numerically calculate sensitivity coefficients. Most of these forward runs are independent from each other and can therefore be performed in parallel. Message passing based on the Parallel Virtual Machine (PVM) system has been implemented into ITOUGH2 to enable parallel processing of forward simulations on a heterogeneous network of Unix workstations or networked PCs that run under the Linux operating system. This paper describes the PVM system and its implementation into ITOUGH2. Examples are discussed, demonstrating the use, efficiency, and limitations of ITOUGH2-PVM. INTRODUCTION Inverse ...
ChemInform Abstract: Direkte Umwandlung von Phospholen in 6,7‐Dihydro‐phosphepine über eine Koordinierung an Wolframverbindungen. (1985)

Abstract Das aus dem Phosphol (I) über (II) zugängliche Chlorethyl‐phosphol (IV) liefert nach Komplexierung mit Wolfram‐carbonyl zu (V) bei der Behandlung mit Aluminiumchlorid das Phosphepin (VI), das mit Methanol zu (VII) austauscht.
Oxidation of tryptophan-21 alters the biological activity and receptor binding characteristics of mouse nerve growth factor. (1980)

The tryptophan residues of P nerve growth factor (J3NGF) were modified by reaction with varying concentrations of N-bromosuccinimide. Analysis of the oxidized derivatives by electrophoresis under denaturing conditions, before and after reduction or oxidation of disulfide bonds, revealed partial hydrolysis of specific peptide bonds. Analysis of the newly created NH2 termini by the 5-dimethylaminonaphthalene-1-sulfonyl procedure showed that the peptide bonds contained the carbonyl group of the reacted tryptophan residues and that the oxidation reaction proceeded in the order Trp21, Trp-99, and Trp-76. To obtain PNGF modified only at Trp-21, 0.9 tryptophan residues/NGF chain were oxidized. The dose-response curves for the PNGF-induced neurite outgrowth on sensory and PC12 cells showed that 20to 30-fold higher concentrations for the 0.9 Trp-OX-NGF YNGF oxidized with N-bromosuccinimide) derivative and about 1000-fold higher concentrations for a 2.0 Trp-OX-NGF derivative were required to elicit half-maximum biological response when compared with native PNGF. This decrease in biological activity was paralleled by a decreased binding to NGF receptors on both sensory and PC12 cells. On sensory cells, the affinity of 0.9 Trp-OX-NGF was 2.5% and the affinity of 2.0 Trp-OX-NGF was 0.05% of that of native PNGF. Tested on PC12 cells, 0.9 Trp-OX-NGF bound with 1.2% of the affinity of native PNGF. At the highest concentration tested, 2.0 Trp-OX-NGF did not compete with the binding of PNGF to PC12 cells. That the residual binding affinity and biological activity of 0.9 TrpOX-NGF were not due to unmodified PNGF in the preparation was ascertained by the PNGF-dependent cytotoxicity assay, which showed that less than 0.2% of unmodified PNGF remained. In contrast to the significant decrease in biological and binding activity, the derivative modified at Trp-21 retained 25% of the antigenicity of the native protein.
Drying: heat and draught (2021)

The arrival and storage of the hops at the kiln. The management of the hops on the drying floor: temperature control, duration of drying period and the use of sulphur explored. Draught and the expulsion of fumes and humidity through cowl. A description of types of open and closed brick furnaces, and cast iron stoves used to heat the kiln. The choice of fuel: charcoal, smokeless coal, wood. Control of the draught using entry vents below and cowls on the roof. The regional variations in cowl design.
Analysis of grain boundary diffusion in bimetallic thin film structures using Auger electron spectroscopy (1975)

The feasibility of using Auger electron spectroscopy (AES) for solute grain boundary diffusion measurements in thin films is explored in this investigation. Diffusion couples of a sandwiched Al/Cu/Al structure were prepared by sequential deposition in the same pumpdown. The composition profile was determined before and after annealing with an AES system which employed argon sputtering for thin film sectioning. It is shown that both the lattice and grain boundary diffusivities can be extracted from the solute profile based on the Whipple analysis of grain boundary diffusion. At 175°C, the grain boundary diffusivity αDbδ for Cu in Al was determined to be 4.3×10−20 cm3/sec with an estimated error of ±7% from the ion etching damage. The agreement between our measured lattice diffusivity and radioactive tracer data is satisfactory. Some of the problems associated with the AES method for diffusion studies are discussed.
Anti‐D investigations in individuals expressing weak D Type 1 or weak D Type 2: allo‐ or autoantibodies? (2011)

A complete anti-D investigation in individuals with a D variant (weak D or partial D identified by molecular analysis) should be systematically performed before any valid conclusion on the nature of the antibody. Transfusing weak D Type 1 or weak D Type 2 patients with D+ RBC units should be recommended. Weak D Type 1 or weak D Type 2 pregnant women do not need anti-D immunoprophylaxis.
Conformation of (1→3)-α-<scp>D</scp>-Glucan Tribenzoate (1993)

Journal Article Conformation of (1→3)-α-D-Glucan Tribenzoate Get access Kozo Ogawa, Kozo Ogawa Research Institute for Advanced Science and Technology, University of Osaka Prefecture, 1-2 Gakuen-cho, Sakai, Osaka593, Japan Search for other works by this author on: Oxford Academic Google Scholar Tohru Shibata, Tohru Shibata Research Institute for Advanced Science and Technology, University of Osaka Prefecture, 1-2 Gakuen-cho, Sakai, Osaka593, JapanDaicel Chemical Industries Ltd., 1239 Shinzaike, Aboshi-ku, Himeji, Hyogo 671-12, Japan Search for other works by this author on: Oxford Academic Google Scholar Hajime Namikoshi, Hajime Namikoshi Research Institute for Advanced Science and Technology, University of Osaka Prefecture, 1-2 Gakuen-cho, Sakai, Osaka593, JapanDaicel Chemical Industries Ltd., 1239 Shinzaike, Aboshi-ku, Himeji, Hyogo 671-12, Japan Search for other works by this author on: Oxford Academic Google Scholar Toshifumi Yui, Toshifumi Yui Research Institute for Advanced Science and Technology, University of Osaka Prefecture, 1-2 Gakuen-cho, Sakai, Osaka593, JapanDepartment of Industrial Chemistry, Miyazaki University, Miyazaki 889-21, Japan Search for other works by this author on: Oxford Academic Google Scholar Keizo Okamura Keizo Okamura Research Institute for Advanced Science and Technology, University of Osaka Prefecture, 1-2 Gakuen-cho, Sakai, Osaka593, JapanDepartment of Wood Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606-01, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 57, Issue 10, 1 January 1993, Pages 1663–1665, https://doi.org/10.1271/bbb.57.1663 Published: 01 January 1993 Article history Published: 01 January 1993 Received: 22 March 1993
STUDIES ON DIACETYL BIOSYNTHESIS BY STREPTOCOCCUS DIACETILACTIS (1963)

Resting cell and cell-free extract experiments demonstrated the presence of citritase, oxaloacetic acid decarboxylase, α-acetolactic acid decarboxylase, and pyruvic acid decarboxylase in Streptococcus diacelilactis. Results indicated that citric acid or pyruvic acid was converted to diacetyl and acetylmethylcarbinol with intermediate synthesis of α-acetolactic acid. Acetylmethylcarbinol also was synthesized by condensation of active and free acetaldehyde. Evidence was obtained for the presence of diacetyl reductase and a reversible 2,3-butanediol dehydrogenase in cell-free extracts of S. diacetilactis. The data suggested that S. diacetilactis produced diacetyl from citrate with the intermediate production of oxaloacetate, pyruvate, and α-acetolactate in that order.
A Method for Predicting Contra Rotating Propellers Off-Design Performance (2014)

This article presents a method for predicting contra rotating propellers individual and total performance which is fast and robust enough to be used in performance engine cycle and engine subsystems detailed design. The method is based on the use of single propeller maps and models mutual induced velocities thanks to one-dimensional theories. These velocities are responsible for interferences between propellers. This article goes through the assumptions on which stands the proposed method and shows that it is relevant compared against more complex methods such as lifting line theory and definitively provides a valuable easy-to-enforce preliminary design tool for open rotor propulsor controls sizing.
HIV-related metabolic abnormalities in the brain: depiction with proton MR spectroscopy with short echo times. (1996)

ADC has a uniform pathologic metabolic pattern that affects NAA, MI, and Cho. Proton MR spectroscopy with short echo times helps detect early abnormalities in clinically asymptomatic patients.
The cumulative effects and clinical safety of repeat magnetic resonance imaging on an MRI-conditional pacemaker system at 1.5 tesla (2020)

These results demonstrate the safety and performance of the ProMRI PPM in patients undergoing 3 serial MRIs over various anatomic regions.
Screening of Advanced Matrix Resin Systems for Use in High Performance Aircraft (1987)

Current and near future requirements for fiber/resin component structures require component materials with superior impact resistance and damage tolerance coupled with good environmental performance. Optimization of the fabrication process for the final matrix resin selection for production of high quality parts with minimum reject rate can be achieved by use of the combination of two computer-assisted techniques developed at Lockheed. These are (1) a generic thermal analyzer model which incorporates heat transfer characteristics of the autoclave, tooling, and curing composite and (2) a matrix resin specific chemoviscosity model which takes into account viscosity, cure exotherm behavior, and chemical kinetics. Chemical characterization, rheometry, and differential scanning calorimetry (DSC) are vital in the assessment of cure behavior characteristics of each resin matrix studied. Matrix resin screening reveals considerable variation in viscosity, cure exotherm behavior, and reaction kinetics during the cure process, especially with matrix resins modified for improvement of damage tolerance.
Nonclassic measles infections in an immune population exposed to measles during a college bus trip (1998)

This study investigated the frequency of mild or asymptomatic measles infections among 44 persons exposed to a student with measles during a 3-day bus trip using two buses. Questionnaires and serum samples were obtained 26-37 days after the trip. All participants had detectable measles-neutralizing antibodies, and none developed classic measles symptoms. Ten persons (23%) were IgM positive for measles, indicating recent infection. Among previously vaccinated IgM-negative persons, those who rode on bus A with the index case-patient had significantly higher microneutralization titers than those on bus B (P= .001), suggesting that some persons on bus A were infected but were IgM negative at the time of the study. Mild or asymptomatic measles infections are probably very common among measles-immune persons exposed to measles cases and may be the most common manifestation of measles during outbreaks in highly immune populations.
Evaluierung der diagnostischen Aussagekraft radiärer Reformatierungen der axialen sCT-Datensätze bei der Verdachtsdiagnose einer Lungenarterienembolie (2005)

Material/Methode: Es wurden 127 CT-Untersuchungen mit der Fragestellung nach einer akuten Lungenarterienembolie radiär reformatiert. Zuvor wurden optimierte Fensterweiten für die Rekonstruktionen von acht erfahrenen Radiologen, je nach HE-Dichte des Kontrastmittels in der A. pulmonalis, festgelegt. Die erneute Beurteilung der Lungengefäße erfolgte durch fünf erfahrene Radiologen. Beurteilt wurden die Position und die Ausdehnung des Thrombus sowie die subjektive Einschätzung der jeweiligen Rekonstruktion bei gleichen Patienten.
The fate of amezinium in humans and animals. (1981)

The metabolism of 14C-labelled 4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate (ameziniummetilsulfate, LU 1631, Regulton), in the following briefly called amezinium, was studied in 6 animal species (dog, cat, rabbit, guinea-pig, rat, and mouse) and in humans. Two-dimensional thin-layer radiochromatography revealed qualitative and quantitative differences between species. In man, dog, cat, guinea-pig, and mouse unchanged amezinium is the principal excretion product, accounting for 56-89% of the radioactivity in the urine whilst metabolites predominate in the rabbit and particularly in the rat. Since besides unchanged amezinium (I) no radioactive substance from the urine is adsorbed on cation exchanger, the first step of biotransformation is assumed to be the formation of uncharged, pharmacologically inactive 5-amino-2-phenyl-3(2H)-pyridazinone (II). The metabolites excreted by man and dog have largely been identified; apart from small quantities of II, hydroxylated pyridazinones and/or their sulfuric acid conjugates were isolated. The formation of the metabolites is discussed.
Site-specific differences in central processing of visceral stimuli from the rectum and the descending colon in men (2009)

These findings suggest that central projections of painful visceral stimulation from the rectum and descending colon differ in affective, cognitive and nociceptive processing in the brain, which may result in different perceptions of visceral stimulation from different sites.