gebhart/patrepeval huggingface dataset:
P08.52 Proton therapy re-Irradiation in large-volume recurrent glioblastoma. (2016)

PURPOSE: To report preliminary results of re-irradiation with proton therapy (PT) in large-volume recurrent glioblastoma (rGBM). MATHERIAL/METHODS: Between January and December 2015 ten patients (pts) with rGBM were re-irradiated with PT. All pts were previously treated with photon radiotherapy (60 Gy) with concomitant and adjuvant TMZ for 1–20 cycles (median, 7). Seven pts were re-irradiated at first relapse/progression. Four patients were re-irradiated after partial tumor resection. Median age and Karnofsky performance status at re-irradiation were 57 years (range, 41–68) and 80%, (range, 70–100), respectively. Median time between prior radiotherapy and PT was 9 months (range, 5–24). Target definition was based on CT, MR, and 18F-DOPA PET imaging. GTV included any area of contrast enhancement after contrast medium administration plus any pathological PET uptake regions. CTV was generated by adding to GTV a 3-mm uniform margin manually corrected in proximity of anatomical barriers. CTV was expanded by 4 mm to create PTV. Median PTV volume was 90 cc (range, 46–231). All pts received 36 GyRBE in 18 fractions. Four pts also received concomitant temozolomide (75 mg/m2/die, 7 days/week). All pts were treated with active beam scanning PT using 2–3 fields with single field optimization technique. RESULTS: All pts completed the treatment without breaks. Registered acute side effects (according to Common Terminology Criteria for Adverse Events version 4.0 - CTCAE) include grade 1–2 skin erythema, alopecia, fatigue, conjunctivitis, concentration impairment, dysphasia, and headache. There were no grade 3 or higher toxicities. One patient developed grade 1 neutropenia. Five pts started PT under steroids (2–7 mg/daily); two of them reduced the dose during PT, while three kept the same steroids dose. None of remaining pts needed steroids therapy. Registered late side effects (according to CTCAE version 4.0) include grade 1–2 alopecia, fatigue, concentration impairment, and dysphasia. During follow-up two pts (20%) developed radionecrosis (diagnosed at imaging) with mild symptoms controlled with steroids. There were no grade 3 or higher toxicities. The median progression-free survival (PFS) was 6.4 months, while the 3-, 6- and 9-month PFS rates were 80%, 67% and 22%, respectively. Median overall survival (OS) after PT was not achieved, while the 6- and 12-month survival after PT rates were 100% and 60%, respectively. CONCLUSION: PT re-irradiation of large-volume rGBM showed to be feasible and safe even with concomitant chemotherapy administration. Despite the small number of patients and the retrospective nature of the study PFS and OS rates were promising and deserve further evaluation in a larger pts sample.
First Successful Rigless Conversion of Subsurface Safety Valves from Tubing Retrievable to Wireline Retrievable in the Middle East (2012)

Abstract In the oil and gas industry, safety systems are put in place to prevent the release of hydrocarbons and protect assets against any undesirable events. This can be accomplished by installing protective measures that monitor the process components, and can also control the process in case of undesirable events. The Surface Controlled Subsurface Safety Valve (SCSSSV) is one major component, which is mainly installed in wells that are located offshore or close to populations and environmentally sensitive areas. These SCSSSV can be categorized into two types depending on the deployment/retrieval methodology. The first type is referred to as the Wire Line Retrievable Subsurface Safety Valve (WLRSSSV), which is installed and retrieved by rigless well intervention and installed inside the production tubing. The other type is the Tubing Retrievable Subsurface Safety Valve (TRSSSV) and these valves are part of the tubing completion. Due to its numerous advantages, like full bore access, and not to retrieve the valve before any intervention, TRSSSV are gaining more popularity. Saudi Aramco uses these types of valves and most of the new completions are designed with TRSSSV. Unfortunately, as these types of valves are part of the completion, any failure to close these valves results in a disturbance in the safety system of the well, which will lead to performing an expensive workover, which is not only costly but the process means killing the well, and therefore inducing damage to the reservoir. This paper presents in detail the procedure applied to these inoperable TRSSSVs to regain the safety of the wells and put them back on production without the need to de-complete the well. The direct business impacts are restoring the well safety system, wells’ productivity in addition to cost avoidance of (onshore and offshore) workover operation to replace the malfunctioning TRSSSVs. The paper will also cover common mitigation measures to mitigate TRSSSV failure and avoid their conversion.
Enhanced Neovascular Formation in a Novel Hydrogel Matrix Consisting of Citric Acid and Collagen (2011)

The TSC-AlCol gel functioned as a favorable scaffold for neovascular formation and also as a reservoir for controlled delivery of bFGF.
Regulation of Genes for HLA Class II Antigens in Cell Lines from Patients with Severe Combined Immunodeficiency (1988)

HLA Class II-negative severe combined immunodeficiency (SCID) results from a congenital defect characterized by an absence of HLA Class II antigens. Patients with the disorder have no HLA-DR, DQ, or DP antigens or mRNAs in their peripheral-blood lymphocytes. The affected gene is a recessive, transacting regulatory gene that controls the expression of Class II genes. We studied the regulation of HLA Class II gene expression with the use of established Epstein-Barr virus-transformed B-cell lines and skin fibroblast lines from a group of patients with SCID. Lymphoblastoid B-cell lines from the patients contained no mRNA for HLA-DR, DQ, and DP alpha and beta polypeptides, but did express mRNA for the HLA-associated invariant chain, which is normally coregulated with HLA Class II antigens. In the B-cell line from one patient, a very low amount of DR mRNA could be detected, indicating some heterogeneity in SCID. The lymphokine gamma-interferon, a strong inducer of Class II genes in a variety of normal cells, did not restore Class II gene expression in any of the SCID B-cell lines. More important, gamma-interferon was unable to induce any Class II mRNA in fibroblast lines from patients with SCID, in contrast to the efficient induction observed in normal fibroblasts. The invariant-chain gene, however, was induced in the SCID fibroblasts, confirming a unique uncoupling in the regulation of invariant and Class II genes. Thus, the genetic defect in patients with SCID affects not only the B-cell lineage but also the inducible expression of HLA Class II genes that is normally observed in Class II-negative cells, such as fibroblasts. This unresponsiveness to gamma-interferon in vitro indicates that patients with SCID will not respond to treatment with this lymphokine. Our data also increase understanding of the normal mechanisms regulating the genes for the HLA Class II cell-surface glycoproteins.
Fascia Wrapping Technique: A Modified Method for the Treatment of Cubital Tunnel Syndrome (2014)

Variations of the anterior transposition of the ulnar nerve for cubital tunnel syndrome include subcutaneous, submuscular, intramuscular, and subfascial methods. We introduce a modification of subfascial transposition, which is designed to facilitate nerve gliding by wrapping the nerve with fascia. Twenty patients with wrapping surgery following the diagnosis of cubital tunnel syndrome were reviewed retrospectively. Preoperative electrodiagnostic studies were performed in all patients and all of them were rechecked postoperatively. The preoperative mean value of motor conduction velocity (MCV) was 37.1 ± 6.7 m/s within the elbow segment and this result showed a decrease compared to the result of MCV with 53.9 ± 6.9 m/s in the below the elbow-wrist segment with statistical significance (P < 0.05). Postoperative mean values of MCV were improved in all of 20 patients to 47.6 ± 5.5 m/s (P < 0.05). 19 patients of 20 (95%) reported good or excellent clinical outcomes according to a modified Bishop scoring system. The surgical treatment methods for cubital tunnel syndrome have their own advantages and disadvantages, and the preferred method differs depending on the surgeon. The wrapping method of anterior transposition is a newly designed alternative method modified from subfascial transposition. This method could be an alternative option to treat cubital tunnel syndrome.
Quadrupole moment of the yrast superdeformed band in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow/><mml:mrow><mml:mn>144</mml:mn></mml:mrow></mml:msup></mml:mrow><mml:mi mathvariant="normal">Gd</mml:mi></mml:math> (1999)

A mean lifetime measurement using the Doppler shift attenuation method has been performed at GASP in order to measure the quadrupole moment of the yrast superdeformed band of ${}^{144}\mathrm{Gd}$. The extracted intrinsic quadrupole moment above the backbending, ${Q}_{0}{=13.7}_{\ensuremath{-}0.9}^{+1.1} e$ b, is in nice agreement with cranked shell model predictions. To fit the data properly below the backbending a smaller ${Q}_{0}$ value is required ${(11.6}_{\ensuremath{-}1.0}^{+1.4})e$ b. This is consistent with the predicted lower deformation in the second well for the configuration without high-$N$ $(\ensuremath{\pi}N=6$ and $\ensuremath{\nu}N=7)$ intruder orbitals occupied.
Les clercs mediévaux au service de l’état (2015)

Trata-se de uma apresentação das principais linhas do projeto DEGRUPE financiado pela FCT bem como de uma reflexão sobre o seu enquadramento historiográfico.
The Maudsley Prescribing Guidelines in Psychiatry (Full-Text Access) (2025)

Abstract This online‐only addendum provides access to a full concatenated copy of 15th Edition of The Maudsley Prescribing Guidelines in Psychiatry for online use. This file is protected by copyright. Please do not share, upload, or distribute this file online or through any other means. Unauthorised sharing may violate copyright law.
An Efficient Preamble Design Based on Comb-Type Pilots for Channel Estimation in FBMC/OQAM Systems (2018)

In this paper, we propose an efficient preamble design based on comb-type pilots (CTP) for channel estimation in filter bank multicarrier with offset quadrature amplitude modulation (FBMC/OQAM) systems. The proposed preamble is similar to the CTP widely adopted in OFDM systems, within a specified window. Thus, it enables OFDM-like channel estimation with low complexity for FBMC/OQAM and removes the inter-symbol interference/inter-carrier interference in FBMC/OQAM channel estimation. Moreover, the proposed preamble design can be easily extended to support multiple antennas (MIMO). Simulation results demonstrate that the proposed preamble length could be very close to those of conventional preamble design such as the interference cancellation method, and the channel estimation with the proposed preamble could obtain good performance both in single antenna and MIMO systems.
Reduced neonatal mortality in a regional hospital in Mozambique linked to a Quality Improvement intervention (2016)

We found a reduction in mortality rate among newborns admitted to CBH's NICU after the first year of CUAMM intervention. Most of this reduction can be attributed to the decrease in deaths for asphyxia, sepsis and prematurity. A Quality Improvement intervention based on infrastructural, equipment and clinical objectives was associated with a reduction of neonatal mortality rate in a low-resource NICU.
Strategic analysis for the MER Cape Verde approach (2009)

The Mars Exploration Rover Opportunity has recently completed a two year campaign studying Victoria Crater. The campaign culminated in a close approach of Cape Verde in order to acquire high resolution imagery of the exposed stratigraphy in the cliff face. The close approach to Cape Verde provided significant challenges for every subsystem of the rover as the rover needed to traverse difficult, un-characterised terrain and approach a cliff face with the potential of blocking out solar energy and communications with Earth. In this paper we describe the strategic analyses performed by the science and engineering teams so that we could successfully achieve the science objectives while keeping the rover safe.
PLANTA SERVOPNEUMÁTICA MONITORADA POR SISTEMA SUPERVISÓRIO COM CÓDIGO ABERTO (2018)

O objetivo deste artigo e demonstrar a implantacao de um software livre para o monitoramento de uma planta servopneumatica, que e dotada de um controlador baseado na plataforma Arduino Due. O software utilizado e o ScadaBr, que tem como principal vantagem o fato de ser baseado em codigo aberto e ser acessivel para os profissionais da automacao. Inicialmente, sera apresentada a planta servopneumatica e o controlador, bem como a programacao do Arduino Due. Em seguida, sera explicada a instalacao do ScadaBr, a configuracao da rede Modbus e como e feita a comunicacao com o software supervisorio. Por fim, sera descrita uma aplicacao em que o ScadaBr monitora, atraves de um grafico, o deslocamento de um eixo da planta servopneumatica.
[Ultrastructural endometrial changes in IUD users]. (1990)

Endometrial biopsies from 20 patients using intrauterine devices (IUD) having different modes of action were taken in order to study the ultrastructural changes related to the different types of devices. 11 patients presented with spotting and/or pelvic discomfort; the others were asymptomatic. The tissue biopsies were observed with electron microscopy. The epithelium appears to be constituted by cells with abnormal nuclei, cilia and microvilli and infiltrated by numerous white cells. The vascular structures of the stroma show changes that explain the frequent bleeding; edema and stromal cell necrosis are also noted. The presence of white cells actually appears to be partially responsible for the efficacy of the devices; the vessel abnormalities are more marked among those using copper-based devices and devices made of inert material. The secretory function of the endometrium appears more significantly diminished in copper-based devices than in the inert devices. Progesterone-based devices cause longer menses and more frequent intermenstrual spotting, but an altogether smaller periodic blood loss. These results confirm the findings of previous studies and the advisability of using medicated IUDs.
Synthesis, Structure, and Physical Properties of Nickel Bis(dithiolene) Metal Complexes, [Ni(dmit)<sub>2</sub>], with Highly Polar Cyanine Dyes (1998)

Three new compounds were obtained by slow diffusion of [Ni(dmit)2]- (dmit = 2-thioxo-1,3-dithiole-4,5-dithiolato) into 4-(dimethylamino)-1-methylpyridinium [C1]+, 4-[2-(4-(dimethylamino)phenyl)ethenyl]-1-methylpyridinium [C2]+, and 4-[4-(4-(dimethylamino)phenyl)-1,3-butadienyl]-1-methylpyridinium [C3]+. [C1]+[Ni(dmit)2]- exhibits two crystallographic phases (1, 2) as does [C2]+[Ni(dmit)2]- (3, 4). The structures have been determined: 1, monoclinic, P21/c, a = 17.450(2) Å, b = 10.646(1) Å, c = 23.891(2) Å, β = 97.42(1)°, Z = 4; 2, triclinic P1̄, a = 9.776(1) Å, b = 15.195(2) Å, c = 16.999(2) Å, α = 114.14(1)°, β = 101.84(1)°, γ = 93.40(1)°, Z = 2; 3, monoclinic, P21/c, a = 9.813(1) Å, b = 11.589(1) Å, c = 24.345(3) Å, β = 93.12(1)°, Z = 4; 4, triclinic, P1̄, a = 13.432(2) Å, b = 16.101(2) Å, c = 6.553(1) Å, α = 99.69(1)°, β = 94.34(1)°, γ = 102.88(2)°, Z = 2; [C1]+[Ni(dmit)2]- (1) exhibits a conductivity of 1.3 × 10-2 S cm-1. Due to centrosymmetry, none of the materials exhibits second-order nonlinear optical properties, but the structure of 1 demonstrates that layers of highly polarizable cations can be stabilized in a noncentrosymmetric environment between two-dimensional networks of [Ni(dmit)2]- species.
Incorporation of carbon dioxide into soybean oil and subsequent preparation and studies of nonisocyanate polyurethane networks (2004)

Abstract Epoxidized soybean oil was effectively converted to carbonated soybean oil (CSBO) containing five‐membered cyclic carbonates by reaction with carbon dioxide in the presence of tetrabutylammonium bromide as catalyst at 110°C in high yield. CSBO could easily react with di‐ or tri‐ primary amines to give the corresponding nonisocyanate polyurethane networks (NIPUs). A model reaction between CSBO and n ‐butylamine showed the effective ring opening of five‐membered cyclic carbonate moieties in the triglyceride molecules by the amine to form β‐hydroxyurethane systems. NIPUs were further characterized by the three techniques of solvent extraction, dynamical mechanical analysis, and limited tensile testing. The data from these methods confirmed the network character of all materials and also showed how the levels of extractables, Tg, and mechanical properties varied with type of amine and, in the case of ethylenediamine, the effect of stoichiometry. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 883–891, 2004
Effect of high-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>κ</mml:mi></mml:math>gate dielectrics on charge transport in graphene-based field effect transistors (2010)

The effect of various dielectrics on charge mobility in single-layer graphene is investigated. By calculating the remote optical phonon scattering arising from the polar substrates, and combining it with their effect on Coulombic impurity scattering, a comprehensive picture of the effect of dielectrics on charge transport in graphene emerges. It is found that though high-$\ensuremath{\kappa}$ dielectrics can strongly reduce Coulombic scattering by dielectric screening, scattering from surface phonon modes arising from them wash out this advantage. Calculation shows that within the available choice of dielectrics, there is not much room for improving carrier mobility in actual devices at room temperatures.
The association between light postural movements and attention of children with cerebral palsy (1900)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Three-Component Olive Oil-In-Water High Internal Phase Emulsions Stabilized by Palm Surfactant and Their Moisturizing Properties (2009)

In the present study, olive oil was used for the preparation of three-component high internal phase emulsions with oil volume fraction of more than 0.77 stabilized by palm-based polyoxyethylene lauryl ether for the first time. These emulsions were investigated on their morphology, structural properties, stability, and hydration efficacy. Droplet size distribution observed from the optical micrographs was in agreement with the light scattering results, which suggested that droplet size was influenced by oil phase and surfactant concentrations. Rheological results exhibiting flow curves cross-over implied structural build-up that gave rise to high stability which was supported by stable three-month storage at an elevated temperature. The hydration efficacy of the emulsion was examined in vivo using a corneometer.
Forum (1979)

Technical Forum Forum R. Eugene Goodson R. Eugene Goodson Purdue University, West Lafayette, Ind. 47907 Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information R. Eugene Goodson Purdue University, West Lafayette, Ind. 47907 J. Dyn. Sys., Meas., Control. Dec 1979, 101(4): 283 (1 pages) https://doi.org/10.1115/1.3426440 Published Online: December 1, 1979 Article history Online: July 13, 2010
Modulation of methylnitrosourea-induced breast cancer in Sprague Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations. (1998)

Dehydroepiandrosterone (DHEA), the major steroid precursor of androgens and estrogens produced in peripheral tissues in primates, is an effective chemopreventive agent in the N-methyl-N-nitrosourea (MNU)-induced rat mammary tumor model. Dietary DHEA (5-600 ppm; 600 mg/kg diet) was administered beginning 1 week before MNU and administered continually throughout the duration of the experiment. The highest dose of DHEA (600 ppm) significantly decreased tumor incidence from 95 to 45% and increased tumor latency and decreased tumor multiplicity from 4.1 to 0.5 tumors/rat. Lower doses of DHEA (5, 24, and 120 ppm) were also effective, decreasing tumor multiplicity by 28, 40, and 55%, respectively, increasing tumor latency in a dose-dependent manner but only minimally affecting final tumor incidence. DHEA in the diet caused a dose-dependent increase in serum levels of DHEA. The 120-ppm dietary dose of DHEA resulted in serum levels of DHEA of approximately 42 pmol/ml levels, similar to those seen in young humans. When we examined whole mounts of mammary glands derived from rats exposed to higher levels of DHEA (600 ppm), we observed a striking increase in lobular development. The doses of DHEA used in these studies (< or =600 ppm) had minimal effects on the induction of fatty acid CoA synthetase, a peroxisome-associated enzyme. In contrast, a dose of 2000 ppm substantially increased levels of peroxisome-associated fatty acid CoA synthetase. The varied and striking efficacy of DHEA was achieved in the absence of any significant effect on body weight gain in the treated rats. Furthermore, tumors from rats treated with MNU alone or rats treated with MNU plus DHEA were examined for the presence of mutations in the Ha-Ras oncogene. There was a slight decrease in the percentage of tumors bearing Ha-Ras mutations in tumors derived from MNU-control rats as contrasted with tumors from MNU-DHEA (120 and 600 ppm)-treated rats. Based on the striking chemopreventive efficacy of continual exposure to DHEA, we examined the effects of more limited exposure to DHEA. Rats were treated with DHEA for a period of 7 weeks immediately before and after MNU injection. Rats were then placed on the control diet for the ensuing 15 weeks. Even this limited exposure to DHEA for a period of 7 weeks profoundly decreased final tumor incidence and multiplicity. Additionally, we examined the effects of intermittent dosing with DHEA. Rats were treated alternatively at 3-week intervals either with diet containing DHEA or with control diet. It was found that this intermittent dosing with DHEA also substantially inhibited the formation of mammary tumors.
Analysis of a pressure driven absorption refrigeration cycle (1988)

This study presents an analysis of a pressure driven absorption refrigeration cycle which utilizes a membrane separation process to achieve refrigerant-absorbent (R/A) separation. Since the performance of such membranes cannot be predicted generally, the analysis is accomplished by computing cycle performance as a function of the effectiveness of the membrane separation process. The net refrigeration effect and work input are determined based on thermodynamic property data for several working fluid combinations, and desirable characteristics for refrigerant-absorbent pairs are identified. The solubility parameter is used to characterize the potential for separation by candidate membrane materials. The absorbent tetraethylene glycol dimethyl ether (E-181) is found to have good potential for separation from Refrigerants 21 and 22 by typical membranes such as cellulose acetate. The coefficient of performance of the proposed cycle is lower than that of a standard vapour compression cycle operating between the same temperature limits. Improved cycle performance may be achieved by development of a working fluid pair having a more nearly optimum combination of properties.