gebhart/patrepeval huggingface dataset:
The non-specific lipid transfer protein (sterol carrier protein 2) acts as a peroxisomal fatty acyl-CoA binding protein (1998)

Conference Article| August 01 1998 The non-specific lipid transfer protein (sterol carrier protein 2) acts as a peroxisomal fatty acyl-CoA binding protein K. W. A. Wirtz; K. W. A. Wirtz 1 *Department of Biochemistry of Lipids, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands 1To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar F. S. Wouters; F. S. Wouters 2 *Department of Biochemistry of Lipids, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar P. H. Bastiaens; P. H. Bastiaens 2 †Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, D-37018 Göttingen, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar R. J. A. Wanders; R. J. A. Wanders ‡Department of Pediatrics, Academic Medical Centre, University of Amsterdam, NL-1105 AZ Amsterdam, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar U. Seedorf; U. Seedorf §Institute for Arteriosclerosis Research, Westfalian-Wilhems-University, D-48129 Münster, Germany Search for other works by this author on: This Site PubMed Google Scholar T. M. Jovin T. M. Jovin †Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, D-37018 Göttingen, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1998) 26 (3): 374–378. https://doi.org/10.1042/bst0260374 Article history Received: March 02 1998 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation K. W. A. Wirtz, F. S. Wouters, P. H. Bastiaens, R. J. A. Wanders, U. Seedorf, T. M. Jovin; The non-specific lipid transfer protein (sterol carrier protein 2) acts as a peroxisomal fatty acyl-CoA binding protein. Biochem Soc Trans 1 August 1998; 26 (3): 374–378. doi: https://doi.org/10.1042/bst0260374 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: nsL-TP, non-specific lipid transfer protein, SCP2, sterol carrier protein 2, PTSI, type 1 peroxisome targeting sequence, Pyr-C12, 12-pyrenyl-dodecanoic acid, FRET, fluorescence resonance energy transfer This content is only available as a PDF. © 1998 Biochemical Society1998 Article PDF first page preview Close Modal You do not currently have access to this content.
Influence of the nonlinear anisotropy of absorption in a passive Cr<sup>4+</sup>: YAG switch on the energy and polarisation characteristics of a neodymium laser (1997)

An experimental investigation was made of the polarisation characteristics of a solid-state neodymium laser with a passive Cr4+ : YAG switch. The energy and the state of polarisation of laser radiation were affected radically by the orientation and position of the Cr4+ : YAG switch in the cavity, and also by the nature of an intracavity polariser. The polarisation characteristics of the laser radiation were determined by a self-induced nonlinear-absorption anisotropy and a self-induced change in the state of polarisation of the laser radiation during growth of a giant pulse when saturation of the absorption was 'switched on' in the Cr4+ : YAG crystal.
Future Research Directions (1998)

This chapter contains sections titled: 7.1 Modularity and Abstraction, 7.2 Faster Inference and Learning, 7.3 Scaling Up to the Brain, 7.4 Improving Model Structures, 7.5 Iterative Decoding, 7.6 Iterative Decoding in the Real World, 7.7 Unification
Experimental bath engineering for quantitative studies of quantum control (2014)

We develop and demonstrate a technique to engineer universal unitary baths in quantum systems. Using the correspondence between unitary decoherence due to ambient environmental noise and errors in a control system for quantum bits, we show how a wide variety of relevant classical error models may be realized through in-phase or in-quadrature modulation on a vector signal generator producing a resonant carrier signal. We demonstrate our approach through high-bandwidth modulation of the 12.6-GHz carrier appropriate for trapped ${^{171}\mathrm{Yb}}^{+}$ ions. Experiments demonstrate the reduction of coherent lifetime in the system in the presence of both engineered dephasing noise during free evolution and engineered amplitude noise during driven operations. In both cases, the observed reduction of coherent lifetimes matches well with quantitative models described herein. These techniques form the basis of a toolkit for quantitative tests of quantum control protocols, helping experimentalists characterize the performance of their quantum coherent systems.
A Stable Isotope-Mass Spectrometric Method for Measuring Human Spermatogenesis Kinetics In Vivo (2005)

This direct kinetic assessment confirms a course of spermatogenesis that is on the shorter side of traditional estimates based on prior analyses. In addition, the variability observed in healthy men suggests that characteristics such as the epididymal reservoir effect may influence the modeling of in vivo spermatogenesis.
Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India (2008)

The data highlights the significance of variations in the ICAM1, PECAM1 and CD36 genes in the manifestation of falciparum malaria in India. The PECAM1 exon 3 SNP exhibits altered association with disease in the endemic and non-endemic region.
Resistance and Stock Propulsion on the High Speed Sealift (HSS) Hybrid Contra-Rotating Shaft-Pod (HCRSP) Concept, Model 5653-3A (2008)

Abstract : A series of model-scale resistance and propulsion experiments were conducted on a Hybrid Contra-Rotating Shaft-Pod (HCRSP) candidate propulsion configuration on a High Speed Sealift (HSS) hullform, as represented by Model 5653-3A. The HCRSP concept consists of two pairs of contra-rotating propellers, where the forward propellers are arranged on conventional shaftlines, and the aft propellers are powered by propulsion pods. At the selected forward-to-aft propeller RPM ratio of 1:1, design displacement, it is predicted that the HSS HCRSP will require a total delivered power, shafts and pods, of 196,111 hP (146.2 MW), at a propeller rotational speed of 110.4 RPM (forward and aft propellers) to attain the 39-knot design objective speed. For the 39-knot objective speed, design displacement, the HSS HCRSP exhibited 9.8% reduction in total delivered power relative to the Joint High Speed Sealift (JHSS) baseline shaft & strut (BSS), a conventional 4-screw open propeller design that shares the same parent sealift hullform. Average reduction in delivered power over the speed range, for the HSS HCRSP relative to JHSS BSS, was 14%.
Conditional Spike Transmission Mediated by Electrical Coupling Ensures Millisecond Precision-Correlated Activity among Interneurons In Vivo (2016)

Many GABAergic interneurons are electrically coupled and in vitro can display correlated activity with millisecond precision. However, the mechanisms underlying correlated activity between interneurons in vivo are unknown. Using dual patch-clamp recordings in vivo, we reveal that in the presence of spontaneous background synaptic activity, electrically coupled cerebellar Golgi cells exhibit robust millisecond precision-correlated activity which is enhanced by sensory stimulation. This precisely correlated activity results from the cooperative action of two mechanisms. First, electrical coupling ensures slow subthreshold membrane potential correlations by equalizing membrane potential fluctuations, such that coupled neurons tend to approach action potential threshold together. Second, fast spike-triggered spikelets transmitted through gap junctions conditionally trigger postjunctional spikes, depending on both neurons being close to threshold. Electrical coupling therefore controls the temporal precision and degree of both spontaneous and sensory-evoked correlated activity between interneurons, by the cooperative effects of shared synaptic depolarization and spikelet transmission.
Unexpected affinity of polysaccharides and its application in separation of enzymes on fluidized beds (2002)

Fluidized bed chromatography is emerging as a powerful tool in bioseparation of proteins/enzymes. In this work, alginate and chitosan beads have been used as affinity media in fluidized mode to selectively capture α-amylases and Aspergillus niger cellulase, respectively. Fairly high yields (>80%), with homogeneity at the level of single band on sodium dodecyl sulfate–polyacrylamide gel electrophoresis, were achieved in all these cases. The main novel features are unexpected affinity of the polysaccharides towards the target enzymes; such macroaffinity ligands avoid any costly chemical steps for affinity ligands; and possibility of easy scale up in fluidized bed mode and single step purification protocols.
The Vitamin D Receptor Represses Transcription of the Pituitary Transcription Factor Pit-1 Gene without Involvement of the Retinoid X Receptor (2005)

Pituitary transcription factor-1 (Pit-1) plays a key role in cell differentiation during organogenesis of the anterior pituitary, and as a transcriptional activator for the pituitary GH and prolactin genes. However, Pit-1 is also expressed in nonpituitary cell types and tissues. In breast tumors, Pit-1 mRNA and protein levels are increased with respect to normal breast, and in MCF-7 human breast adenocarcinoma cells, Pit-1 increases GH secretion and cell proliferation. We report here that 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] administration to MCF-7 cells induces a significant decrease in Pit-1 mRNA and protein levels. By deletion analyses, we mapped a region (located between -147 and -171 bp from the transcription start site of the Pit-1 gene) that is sufficient for the repressive response to 1,25-(OH)2D3. Gel mobility shift and chromatin immunoprecipitation assays confirmed the direct interaction between the vitamin D receptor (VDR) as homodimer (without the retinoid X receptor), and the Pit-1 promoter, supporting the view that Pit-1 is a direct transcriptional target of VDR. Our data also indicate that recruitment of histone deacetylase 1 is involved in this repressive effect. This ligand-dependent Pit-1 gene inhibition by VDR in the absence of the retinoid X receptor seems to indicate a new mechanism of transcriptional repression by 1,25-(OH)2D3.
Chemical Durability of Optical Glass (1982)

Polished surface of optical glass has a tendency to deteriorate in the fabrication process. Typical deteriorations are dimming, staining and latent scratch. Dimming is formed due to the chemical reaction between glass and a small quantity of water such as condensed dew on glass surface. Staining is generated due to the chemical reaction between glass and relatively a large quantity of water. Soluble components are dissolved into water, and then a thin residual surface layer which has lower index than matrix glass cause interference color. And latent scratch is caused by over-all dissolution of glass surface. Tiny undetectable scratches formed in polishing process grow to detectable size as a result of surface dissolution in the ultra-sonic cleaning process.
Can an ankle-foot orthosis change hearts and minds? (2011)

The current military conflicts of Operation Enduring Freedom and Operation Iraqi Freedom have been characterized by high-energy explosive wounding patterns, with the majority affecting the extremities. While many injuries have resulted in amputation, surgical advances have allowed the orthopaedic surgeon to pursue limb salvage in the face of injuries once considered unsalvageable. The military limb salvage patient is frequently highly active and motivated and expresses significant frustration with the slow nature of limb salvage rehabilitation and continued functional deficits. Inspired by these patients, efforts at this institution began to provide them with a more dynamic orthosis. Utilizing techniques and technology resulting from cerebral palsy, stroke, and amputation research, the Intrepid Dynamic Exoskeletal Orthosis was created. To date, this device has significantly improved the functional capabilities of the limb salvage wounded warrior population when combined with a high-intensity rehabilitation program. Clinical and biomechanical research is currently underway at this institution in order to fully characterize the device, its effect on patients, and what can be done to modify future generations of the device to best serve the combat-wounded limb salvage population.
Impact of RF impairments on HSDPA performance (2004)

An important feature of HSDPA (high speed downlink packet access) for WCDMA is to provide very high data rates, up to several Mb/s in the downlink. In order to achieve these high data rates, a good receiver design is needed. Further, from a terminal perspective, the receiver design needs to be efficient from a cost, current and size perspective. A direct conversion receiver fulfills these criteria. However, such a receiver design often suffers from DC-offset and I/Q gain and phase mismatch, degrading the receiver performance. In this paper we make an analysis of how such impairments affect the performance in HSDPA. It is furthermore shown in the paper that by doing a good receiver design the implementation losses due to direct conversion impairments can be made small providing a possibility to make cost efficient HSDPA terminals with good receiver performance.
Minutes of the (2011)

1. Opening Comments Because there were no residents in attendance, Chairman Rosato dispensed with the normal explanation that this meeting was to review the 2011 classifications and valuations of Harris Township property, used to calculate taxes payable in 2012. Any person feeling aggrieved could discuss their complaint with the Assessors and the Board. The meeting was to be kept orderly and anyone becoming loud or out of order would be asked to leave. The complaints would be reviewed in the order they appeared on the sign-in list. It was noted that Supervisors Key and Kortekaas had both completed the Board of Appeal and Equalization training and certification prior to today’s meeting
A Complete Second Gut Induced by Transplanted Micromeres in the Sea Urchin Embryo (1993)

Founder cells for most early lineages of the sea urchin embryo are probably specified through inductive intercellular interactions. It is shown here that a complete respecification of cell fate occurs when 16-cell stage micromeres from the vegetal pole of a donor embryo are implanted into the animal pole of an intact recipient embryo. Animal pole cells adjacent to the transplanted micromeres are respecified from presumptive ectoderm into vegetal plate founder cells. These induced vegetal plate cells express the entire battery of genes characteristic of the endogenous vegetal plate cells. The ectopic vegetal plate invaginates during gastrulation to form a second archenteron which differentiates properly into a tripartite gut, as shown by the spatial pattern of expression of an endoderm-specific marker gene. Thus, transplanted micromeres can signal neighboring cells to induce them to change their fate.
New Zinc Complexes bearing κ<sup>2</sup>-Heteroscorpionate Ligands: Influence of Second-Sphere Bonding Interactions on Reactivity and Properties (2009)

New zinc complexes (LOMe)ZnCl(2) (1) and (LOH)ZnCl(2)(2) of the heteroscorpionate ligands 1-[(3,5-di-tert-butyl-2-methoxyphenyl)(3,5-dimethyl-pyrazol-1-yl)methyl)]-3,5-dimethyl-pyrazole (LOMe) and 2,4-di-tert-butyl-6-[bis(3,5-dimethyl-pyrazol-1-yl)methyl]phenol (LOH) have been synthesized. The X-ray molecular structure of 2 was reported and compared with the one of the iron(II) complex (LOH)FeI(2) (3). The complexes 2-3 adopt a tetrahedral structure in the solid state in which the LOH ligand is kappa(2)-coordinated to the metal via the imino nitrogens of the two pyrazolyl rings. The hydroxyl phenyl group is not coordinated to the metal but found to be involved in an intermolecular hydrogen bond. The solution structures of 1 and 2 are consistent with this tetrahedral C(S) symmetric geometry. Dilution and (1)H-(1)H Nuclear Overhauser Effect Spectroscopy (NOESY) experiments revealed that the free ligands LOMe and LOH are involved in intra- and intermolecular hydrogen bonding interactions. Coordination of LOMe and LOH to ZnCl(2) was investigated by NMR titration methods. Association constants (K(a)) of (8.6 +/- 0.4) x 10(2) M(-1) and (7.8 +/- 0.3) x 10(2) M(-1) were obtained in methanol/water solutions (95:5) for LOMe and LOH, respectively. Coordination of bis(3,5-dimethyl-pyrazol-1-yl)methane (bpm) ligand to ZnCl(2) is weaker, as evidenced by the lower value of the association constant (5.3 +/- 0.3) x 10(2) M(-1). When bpm was added to solutions of 1 or 2, an equilibrium shifted toward the (bmp)ZnCl(2) species was observed. The thermodynamic parameters for this reaction were determined by VT NMR analysis. The optical properties of the ligands (LOMe, LOH) and of the corresponding zinc complexes 1 and 2 were also investigated by means of UV-vis and fluorescence spectroscopy to assess the potential use of these ligands as fluorescent sensors for Zn(2+) detection.
Finite Element Analysis of Alternating Phase-Shift Masks Subjected to Dynamic Pressure Loading Due to Megasonic Cleaning (2008)

The mechanical response of alternating phase-shift mask (APSM) microstructures to dynamic pressure loading during megasonic cleaning was analyzed with the finite element method (FEM). A parametric study of the effects of microstructure dimensions, pressure amplitude, and loading frequency on the mask structural integrity was performed for two typical chromium/quartz APSM patterns. Damage due to microfracture and plastic deformation processes encountered during megasonic cleaning was examined for frequencies of 1, 5, and 10 MHz. FEM results provide insight into possible damage modes and critical microstructure dimensions for catastrophic failure. Damage scenarios revealed by FEM results are in qualitative agreement with experimental observations. The results of this study have direct implications in the design of extreme ultraviolet lithography masks and the optimization of the megasonic cleaning process.
BATMAN and ROBIN: DMD-based spectro-imagers (2016)

In Universe Observation, we propose BATMAN, an innovative DMD-based spectro-imager instrument to be installed by 2017 on a 4m-class telescope, the Telescopio Nazionale Galileo. ROBIN, BATMAN pathfinder, demonstrates the instrument abilities.
Use of the post-insertion method for the formation of ligand-coupled liposomes. (2002)

A new technique is described for the formation of ligand-targeted liposomes that can be used with whole antibodies, antibody fragments, peptides or other ligands. The ligands are coupled to polyethylene glycol micelles and then transferred in a simple incubation step from the micelles into the outer monolayer of pre-formed, drug-loaded liposomes. This versatile method allows a combinatorial approach to the design of targeted liposomes that minimises manufacturing complexities, allowing a variety of ligands to be inserted into a variety of pre-formed liposomes containing a variety of drugs. This allows the ligand-targeted therapeutics to be tailored to the needs of individual patients.
Characterisation of Ni–P electroless deposits with moderate phosphorus content (1997)

The influence of the phosphorus content on hardness, structure, and morphology of electro less Ni–P deposits on an AISI 1020 steel substrate was investigated. The deposits were prepared from acidic plating solutions based on nickel chloride, as the source of nickel cations, and sodium hypophosphite, as the reducing agent. Coatings with an average of 4·68 and 6·65 wt-%P were obtained, which were analysed using glow discharge optical emission spectroscopy. Variation of phosphorus content with coating thickness was observed when the pH of the solution was not controlled rigorously. The coated samples were annealed at 170°C for 1 h in order to eliminate hydrogen, then post-treated for 25 h at 260°C or 1h at 400°C. X-ray diffraction studies indicated that the as deposited coatings presented a microcrystalline/amorphous or an amorphous structure depending on the phosphorus content. After both heat treatments, a strong (111) preferred orientation was found and coarsening of the grain sizes occurred with increase in temperature. The maximum hardness achieved was 916 HK(100 g) (0.63 GPa). Scanning electron microscopy studies have revealed a nodular, cauliflower type morphology. Extended cracks through the coating surface were observed when the heat treatment was performed at 400°C. A crack free surface was obtained when the heat treatment was performed at 260°C.
Evaluation of Outcome Based on Platelet Function in Elderly Patients with Various Diseases. (2002)

This study was conducted to clarify the relationship between the outcome of various diseases in elderly patients and platelet function. The outcome in 347 consecutive patients aged 60 or older, who were treated without antiplatelet drugs on registration, was retrospectively studied after platelet aggregability tests. The mean age was 77.5 years (161 men and 186 women). The grading curve (GC) type, as an index of platelet aggregability, was determined spectrophotometrically with an aggregometer and adenosine-5'-diphosphate as an agonist. They were classified into three groups according to GC type: Group I with a GC type of -2 or -1 (n = 40), group II with a GC type of 0 or +1 (n = 208), and group III with a GC type of +2 or +3 (n = 99). The mean follow-up period was 3.9 years. There were 3 deaths in group I, 33 in group II, and 30 in group III. Mean annual mortality rate was 2.1% in group I, 4.0% in group II, and 7.5% in group III. Among causes of death, vascular events was seen in 15 patients of group III, although the most common cause of death was pneumonia in the three groups. The annual mortality rates due to vascular events were 0.7% in group I, 0.6% in group II, and 4.2% in group III, indicating a significantly higher mortality rate in group III. Antiplatelet therapy was performed in approximately 15% of each group during their clinical course, and, when they were excluded for survival analyses, annual mortality rate was also higher in group III than in groups I and II. Cox proportional hazards models for vascular death yielded a hazard ratio of 2.3 and 2.2 in the increased GC type and diabetes, respectively. These findings indicated that elderly patients with accelerated aggregability had higher mortality rates due to vascular events. Therefore, accelerated aggregability in the elderly suggested not only the progress of arteriosclerosis, but indications of antiplatelet therapy to prevent vascular events.