gebhart/patrepeval huggingface dataset:
A microPET/CT system for<i>invivo</i>small animal imaging (2007)

A microCT scanner was designed, fabricated and integrated with a previously reported microPET II scanner (Tai et al 2003 Phys. Med. Biol. 48 1519, Yang et al 2004 Phys. Med. Biol. 49 2527), forming a dual modality system for in vivo anatomic and molecular imaging of the mouse. The system was designed to achieve high-spatial-resolution and high-sensitivity PET images with adequate CT image quality for anatomic localization and attenuation correction with low x-ray dose. The system also has relatively high throughput for screening, and a flexible gantry and user interface. X-rays were produced by a 50 kVp, 1.5 mA fixed tungsten anode tube, with a focal spot size of 70 microm. The detector was a 5 x 5 cm(2) photodiode detector incorporating 48 microm pixels on a CMOS array and a fast gadolinium oxysulfide (GOS) intensifying screen. The microCT system has a flexible C-arm gantry design with adjustable detector positioning, which acquires CT projection images around the common microPET/CT bed. The design and the initial characterization of the microCT system is described, and images of the first mouse scans with microPET/CT scanning protocols are shown.
Realization of the luminous-flux unit using a LED scanner for the absolute integrating-sphere method (2000)

In the absolute integrating-sphere method, the total luminous flux of a lamp inside an integrating sphere is determined by comparing it with a known flux introduced into the sphere from an external light source. As the measurement geometry of the lamps to be compared is different, the spatial non-uniformity of the sphere surface may affect the results. In order to evaluate this effect, the spatial response must be measured. Miniature incandescent lamps have been used as scanning-beam sources in previous realizations, but these lamps are not widely available. In the present realization of the luminous-flux unit by the Helsinki University of Technology (HUT), light-emitting diodes (LEDs) were used as the light source in scanning the spatial response. Preliminary results confirm the applicability of the LED scanner and indicate moderate deviations of about 1 % from earlier luminous-flux calibrations.
Fluorescence lifetime imaging of articular cartilage (2004)

Introduction Fluorescence lifetime imaging (FLIM) provides a contrast parameter for tissue components independent of wavelength, spectrum or polarization. It has been shown that contrast between autofluorescent matrix components such as collagen and elastin is available through FLIM ( Siegel et al . 2003 ; Dowling et al . 1998 ), which is not clear using other fluorescent techniques. The lifetime of collagen has been studied whilst in solution; however, research is ongoing to quantify its fluorescence whilst in tissue. The aim of this study was to investigate the contrast available by applying fluorescence lifetime imaging (FLIM) to articular cartilage, which has extracellular matrix containing collagen type‐II and proteoglycan. Materials and methods A time‐gated FLIM system was used to analyse the articular cartilage from unstained sections of human femurs as well as from the knee joints young and old sheep. The sections were also observed under a conventional fluorescence microscope, and for the human femurs, adjacent H&E‐stained sections were also obtained. Details of the FLIM system can be found elsewhere ( Dowling et al . 1998 ), with the laser source being tuneable, allowing excitation over a range 350–600 nm. Fluorescence half‐lives were obtained using single exponentials applied to the intensity decay data. Results It was found that younger cartilage was generally less fluorescent than older. For example, when exciting at 401 nm and observing above 450 nm, it was found that the young sheep samples provided a signal to noise ratio too low to obtain lifetime data, whereas other samples fluoresced brightly. It was also found that within the matrix, FLIM provided contrast unavailable with conventional fluorescence microscopy and, in the case of human femurs, with H&E stains. Discussion In the study of collagen, it is believed that the cross‐linkages are responsible for fluorescence ( Richards‐Kortum & Sevick‐Muraca 1996 ). Because the cross‐linkages increase with age, the fluorescence intensity is also expected to increase. The lesser amount of fluorescence from the younger samples therefore suggests that the dominant fluorophore in cartilage is collagen. The contrast obtained with FLIM in the cartilage indicates nonuniformity in the matrix structure. Acknowledgements This work was supported by the EPSRC, BBSRC, Kentech Instruments, a DTI Beacon award and a Wellcome Trust Showcase award.
Ellagitannins and lignins in aging of spirits in oak barrels (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEllagitannins and lignins in aging of spirits in oak barrelsCarole. Viriot, Augustin. Scalbert, Catherine. Lapierre, and Michel. MoutounetCite this: J. Agric. Food Chem. 1993, 41, 11, 1872–1879Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/jf00035a013https://doi.org/10.1021/jf00035a013research-articleACS PublicationsRequest reuse permissionsArticle Views1005Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Clinical Evaluation of Local Ocular Toxicity in Candidate Anti-Adenoviral Agents in vivo (2009)

These drugs may be possible candidates as eye drops for adenoviral conjunctivitis but further study is required to prove its safety.
The Politics of ‘New Morality’ Lamb, Coleridge, Wordsworth (1992)

Émile Legouis began his Early Life of William Wordsworth by detailing the poet’s hopes for The Recluse as a poem of philosophic consolation amid revolutionary defeat. The intersection of revolutionary politics and poetry was, of course, a recurrent concern in Hazlitt’s Spirit of the Age and, with particular reference to Wordsworth and. Coleridge, in his essay ‘My First Acquaintance with Poets’. But Legouis was the first critic to present a detailed exploration of the links between political disappointment and the genesis of The Recluse and The Prelude. This is a subject that has now become so familiar that it is worth stressing Legouis’ role in establishing this radical political context for Wordsworth’s poetry.
Genetic diversity trends in Central European heterotic groups (2006)

It has been claimed that the system that delivers the products of plant breeding reduces the diversity of cultivated varieties, leading to increased genetic vulnerability. The objective of our study was to monitor the temporal trends in genetic diversity over the past five decades among maize cultivars with the largest acreage in Central Europe. Thirty individuals of five prominent open-pollinated varieties (OPVs) from Central Europe, 85 maize hybrids of economic importance, and their dent and flint parental components were examined with 55 SSRs. The genetic variation within and among varieties decreased significantly during the five decades. The five OPVs contain numerous unique alleles that were absent from the elite flint pool. Consequently, OPVs could represent useful sources for broadening the genetic base of elite maize breeding germplasm.
Metal-Pushing V-Belt-Type CVT. Relationship between Transmitting Torque and Pulley Thrusts. (1994)

Transmitted torque, thrusts of driving and driven pulleys, and axial force between two pulleys were measured on a metal-pushing V-belt-type CVT. Thrust ratios between driving and driven pulleys at several different speed ratios were plotted with respect to torque ratio and compared. It was found that the relationship between thrust ratio and speed ratio was almost independent of rotational speed of the pulley and the maximum transmittable torque at a constant torque ratio. The thrust ratio is primarily a function of speed ratio. It also depends on torque ratio and coefficient of friction between blocks and a pulley. An empirical equation for pulley thrust balance was derived. The equation is expressed in an explicit form. It is so simple that it can be applicable to electronic control of CVT.
Release of Mast-Cell-Derived Mediators after Endobronchial Adenosine Challenge in Asthma (1995)

Abstract Preformed and newly generated mediators released from airway mast cells may play a role in adenosine-induced bronchoconstriction. To investigate the possible role of mast-cell-derived mediator release in mediating bronchoconstriction induced by adenosine 5'-monophosphate (AMP), we have examined the fluid obtained by bronchoalveolar lavage for inflammatory mediators and markers of airway permeability immediately after instillation of AMP directly into an airway segment of 10 asthmatic subjects. Eight subjects completed the protocol. When compared with the saline-challenged segment, the response to endobronchial stimulation with AMP was characterized by a prompt reduction in airway caliber paralleled by a significant rise in PGD2, histamine, and tryptase levels in the lavage fluid. After AMP challenge, the median (range) concentration for PGD2 increased from 36 to 205 pg/ml (p = 0.006), for histamine from 184 to 433 pg/ml (p = 0.018), and for tryptase from 0.30 to 0.54 ng/ml (p = 0.013). In addition, a small but significant rise in albumin levels (from 27.8 to 36.1 micrograms/ml; p = 0.031) was detected after endobronchial challenge with AMP. These findings indicate that adenosine-induced responses may be initiated by the acute release of mast-cell-derived mediators, including PGD2, histamine, and tryptase.
Influence of Bronchomotor Tone on Maximal Expiratory Flow Rates (1970)

Conference Abstract| March 01 1970 Influence of Bronchomotor Tone on Maximal Expiratory Flow Rates A. J. S. Gardiner; A. J. S. Gardiner 1Respiratory Division, Royal Victoria Hospital, McGill University, Montreal2Royal Infirmary, Aberdeen Search for other works by this author on: This Site PubMed Google Scholar L. Wood; L. Wood 1Respiratory Division, Royal Victoria Hospital, McGill University, Montreal2Royal Infirmary, Aberdeen Search for other works by this author on: This Site PubMed Google Scholar P. Gayrard; P. Gayrard 1Respiratory Division, Royal Victoria Hospital, McGill University, Montreal2Royal Infirmary, Aberdeen Search for other works by this author on: This Site PubMed Google Scholar H. Menkes; H. Menkes 1Respiratory Division, Royal Victoria Hospital, McGill University, Montreal2Royal Infirmary, Aberdeen Search for other works by this author on: This Site PubMed Google Scholar P. T. Macklem P. T. Macklem 1Respiratory Division, Royal Victoria Hospital, McGill University, Montreal2Royal Infirmary, Aberdeen Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (1970) 38 (3): 18P–19P. https://doi.org/10.1042/cs038018Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation A. J. S. Gardiner, L. Wood, P. Gayrard, H. Menkes, P. T. Macklem; Influence of Bronchomotor Tone on Maximal Expiratory Flow Rates. Clin Sci 1 March 1970; 38 (3): 18P–19P. doi: https://doi.org/10.1042/cs038018Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1970 The Biochemical Society and the Medical Research Society1970 Article PDF first page preview Close Modal You do not currently have access to this content.
Effect of staurosporine on growth and hyphal morphology of Pleurotus ostreatus (1993)

Staurosporine is a strong inhibitor of protein kinases. At low concentrations, this antibiotic inhibited the growth of both protoplasts and mycelium of Pleurotus ostreatus. Its minimum inhibitory concentrations were 6·5 M and 9·6 M for protoplasts and mycelium, respectively. At a lower concentration (0·54 µM), it caused swelling of hyphal tips and subapical regions while some hyphae became stubby and bulbous. The phenomena were compared with the morphological effects of polyoxin D, which is a competitive inhibitor of chitin synthase. The results suggest the involvement ofprotein kinases(s) in regulation of apical growth of fungi.
Regulation of podocyte BK<sub>Ca</sub>channels by synaptopodin, Rho, and actin microfilaments (2010)

Mechanosensitive large-conductance Ca(2+)-activated K(+) channels encoded by the Slo1 gene (BK(Ca) channels) are expressed in podocytes. Here we show that BK(Ca) channels reciprocally coimmunoprecipitate with synaptopodin (Synpo) in mouse glomeruli, in mouse podocytes, and in a heterologous expression system (HEK293T cells) in which these proteins are transiently expressed. Synpo and Slo1 colocalize along the surface of the glomerular basement membrane in mouse glomeruli. Synpo interacts with BK(Ca) channels at COOH-terminal domains that overlap with an actin-binding domain on the channel molecule that is necessary for trafficking of BK(Ca) channels to the cell surface. Moreover, addition of exogenous beta-actin to mouse podocyte lysates reduces BK(Ca)-Synpo interactions. Coexpression of Synpo increases steady-state surface expression of BK(Ca) channels in HEK293T cells. However, Synpo does not affect the stability of cell surface BK(Ca) channels, suggesting a primary effect on the rate of forward trafficking, and Synpo coexpression does not affect BK(Ca) gating. Conversely, stable knockdown of Synpo expression in mouse podocyte cell lines reduces steady-state surface expression of BK(Ca) channels but does not affect total expression of BK(Ca) channels or their gating. The effects of Synpo on surface expression of BK(Ca) are blocked by inhibition of Rho signaling in HEK293T cells and in podocytes. Functional cell surface BK(Ca) channels in podocytes are also reduced by sustained (2 h) but not acute (15 min) depolymerization of actin with cytochalasin D. Synpo may regulate BK(Ca) channels through its effects on actin dynamics and by modulating interactions between BK(Ca) channels and regulatory proteins of the podocyte slit diaphragm.
Area-level poverty and preterm birth risk: A population-based multilevel analysis (2008)

Women residing in socioeconomically deprived areas are at increased risk of preterm birth, above other underlying risk factors. Although the risk increase is modest, it affects a large number of pregnancies.
Quantifying Nursing Workflow in Medication Administration (2007)

New medication administration systems are showing promise in improving patient safety at the point of care, but adoption of these systems requires significant changes in nursing workflow. To prepare for these changes, the authors report on a time-motion study that measured the proportion of time that nurses spend on various patient care activities, focusing on medication administration-related activities. Implications of their findings are discussed.
Design of Lone-Scale Indicating Instruments (1942)

FROM the viewpoint of utility, the scale length of an indicating instrument bears somewhat the same relationship to its dimensions as does the output of a motor to its frame size. The end product of an instrument is quantitative information. The longer and more legible the scale, the more definite the resulting scale readings, through reduction of observational errors both in the initial calibration and in subsequent use. Thus, instrument designers have endeavored to produce maximum scale lengths within a given space, examples of which are 5-inch scales of 6-inch rectangular switchboard instruments, and the 3 1/2-inch scales of 4-inch rectangular instruments. In general, however, the movements of such instruments have been restricted to an angular deflection of about 90 degrees, with consequent limitation in scale lengths as compared to the scale lengths of non-electrical instruments such as steam and pressure gauges. A study of these fundamentals leads the authors, who attacked the problem of designing a new line of switchboard instruments, to the conclusion that a definite contribution to measurement technique could best be made by designing such instruments for long-range indication, and the smallest practicable panel space.
Finite Approximate Consensus for Privacy in Distributed Sensor Networks (2019)

With concepts such as the Internet of Things becoming more commonplace, greater emphasis must be placed on data privacy in large-scale public networks for these to be used securely without the threat of data theft. Most current distributed processing research deals with improving the flexibility and convergence speed of algorithms for networks of finite size with no constraints on information sharing and no concept for expected levels of signal privacy. In this work we investigate the concept of data privacy in unbounded public networks, where processing approximation is seen as a means to restrict information travel. We describe a practical method to use during processing aggregation stages that may be implemented in hardware to restrict the distance that data is shared. This method is efficient to implement, and requires very few update iterations to perform. We simulate the method and demonstrate its performance for the task of distributed acoustic beamforming in microphone sensor networks.
The Composer's "Standard Operating Procedure" as Evidence of Intention: The Case of a Formal Quirk in Mozart's K. 595 (1987)

Research Article| January 01 1987 The Composer's "Standard Operating Procedure" as Evidence of Intention: The Case of a Formal Quirk in Mozart's K. 595 David Rosen David Rosen Search for other works by this author on: This Site PubMed Google Scholar Journal of Musicology (1987) 5 (1): 79–90. https://doi.org/10.2307/763825 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation David Rosen; The Composer's "Standard Operating Procedure" as Evidence of Intention: The Case of a Formal Quirk in Mozart's K. 595. Journal of Musicology 1 January 1987; 5 (1): 79–90. doi: https://doi.org/10.2307/763825 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentJournal of Musicology Search This content is only available via PDF. Copyright 1987 Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
Early changes of type 2B fibers after denervation of rat EDL skeletal muscle (2002)

Skeletal muscle type 2B fibers normally receive a moderate level of motoneuron discharge. As a consequence, we hypothesize that type 2B fiber properties should be less sensitive to the absence of the nerve. Therefore, we have investigated the response of sarcoplasmic reticulum and myofibrillar proteins of type 2B fibers isolated from rat extensor digitorum longus muscle after denervation (2 and 7 days). Single fibers were identified by SDS-PAGE of myosin heavy chain isoforms. Electrophysiological and isometric contractile properties of the whole muscle were also analyzed. The pCa-tension relationship of type 2B single fibers was shifted to the left at 2 days and to right at 7 days after denervation, with significant differences in the Hill coefficients and pCa threshold values in 2- vs. 7-day-denervated fibers. The sarcoplasmic reticulum Ca2+ uptake capacity and rate significantly decreased after 2 days of denervation, whereas both increased at 7 days. Caffeine sensitivity of sarcoplasmic reticulum Ca2+ release was transitory and markedly increased in 2-day-denervated fibers. Our results indicate that type 2B fiber functional properties are highly sensitive to the interruption of nerve supply. Moreover, most of 2-day-denervated changes were reverted at 7 days.
ACE inhibitors are endothelium dependent vasodilators of coronary arteries during submaximal stimulation with bradykinin (1993)

ACE inhibitors selectively potentiate endothelium dependent relaxations to submaximal concentrations of bradykinin in bovine and human coronary arteries by a local mechanism. This effect on endothelial cells might occur in addition to augmented bradykinin concentrations in the blood and reduced angiotensin II generation.
Effects of maternal uninephrectomy on the development of fetal rat kidney: apoptosis and the expression of oncogenes (2006)

The present study was designed to explore whether maternal uninephrectomy affects development of the collecting ducts in fetal kidney. Localization of DNA fragmented cells in the kidney of fetal rats from uninephrectomized mothers were examined by the terminal deoxynucleotidyl transferase (TdT)-mediated d-UTP-biotin nick end labeling (TUNEL) method. Immunohistochemistry was used to examine the localizations of bcl-2 gene products. The gene expressions for bcl-2, p53, and WT1 mRNAs were examined by using the semi-quantitative reverse transcript-polymerase chain reaction. TUNEL positive cells were more numerous in the medullary collecting ducts of the fetuses from uninephrectomized mothers than in those of the fetuses from sham-operated ones. The expressions of bcl-2, p53, and WT1 mRNAs were lower in the fetuses from uninephrectomized mothers than in the fetuses from sham-operated ones. Cells in the medullary collecting ducts showed positive reactions to anti-bcl-2 gene products antibody with the reactions being weaker in the fetuses from uninephrectomized mothers. These results showed that maternal uninephrectomy accelerated the development of fetal rat kidney and it was associated with the lowered the expression of bcl-2 in fetal rat kidney.
Amorphous copolyesters based on bibenzoic acids and neopentyl glycol (2018)

ABSTRACT High T g amorphous copolyester thermoplastics were synthesized by incorporating 4,4′‐bibenzoate (4,4′BB) and 3,4′‐bibenzoate moieties into the polyester backbone via melt polycondensation. The high levels of crystallinity typically associated with 4,4′BB containing polyesters were suppressed through copolymerization of ethylene glycol, 1,4‐cyclohexane dimethanol, and neopentyl glycol (NPG) diols. NPG was shown to be highly effective in suppressing crystallization and was used to produce amorphous compositions with T g ’s as high as 129 °C. Diol ratios were determined by 1 H NMR spectroscopy and molecular weights were assessed with inherent viscosity ( η inh ). Thermogravimetric analysis showed single‐step weight losses in the range of 395 – 419 °C. Differential scanning calorimetry was used to determine melting points and glass transition temperatures over a wide range of copolyester compositions and identified amorphous compositions. Dynamic mechanical analysis confirmed T g ’s and was used to study β ‐relaxations below the T g . Rheological analysis revealed the effect of NPG structures on shear thinning and thermal stability. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57 , 579–587