gebhart/patrepeval huggingface dataset:
Nature of the ‘[Ir(bpy)<sub>2</sub>(H<sub>2</sub>O)(bpy)]<sup>3+</sup>’, (bipy = 2,2′-bipyridine) cation. Monodentate or covalently hydrated bipyridine ligand? X-Ray crystal structure of the perchlorate salt (1981)

A single-crystal X-ray structural study of the ClO4– salt of the title cation demonstrates this species contains neither a monodentate nor a covalently hydrated bipyridine ligand; all three bipyridine ligands are chelated to iridium(III) but one bipyridine ligand is ligated via the nitrogen of one ring and the C(3) carbon of the other ring, reminiscent of orthometallated compounds.
Enoläther, X. Kinetik und Mechanismus der Cycloaddition von p‐Toluolsulfonylisocyanat an Enoläther; Kinetik der Epimerisierung und Umlagerung der gebildeten 4‐Alkoxy‐1‐tosyl‐3‐alkyl‐azetidinone‐(2) (1971)

Abstract Die Reaktionsgeschwindigkeiten der Cycloaddition von Tosylisocyanat 1 an die Enoläther 2 – 9 , die Epimerisierung der hierbei gebildeten Azetidinone 13 – 20 und deren nachfolgende Umlagerung zu β‐Alkoxy‐acrylamiden jeweils in CCl 4 und CD 3 CN werden NMR‐spektroskopisch bestimmt. Stereochemische Befunde, Aktivierungsparameter sowie die unterschiedliche Beeinflussung von Cycloadditions‐ und Isomerisierungsgeschwindigkeit durch Substituenten und Solvenspolarität machen für die Cycloaddition einen Synchronmechanismus mit Partialladungen im Übergangszustand wahrscheinlich.
Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology (2016)

Accelerator mass spectrometry (AMS) has been adopted as a powerful bioanalytical method for human studies in the areas of pharmacology and toxicology. The exquisite sensitivity (10<sup>-18</sup> mol) of AMS has facilitated studies of toxins and drugs at environmentally and physiologically relevant concentrations in humans. Such studies include risk assessment of environmental toxicants, drug candidate selection, absolute bioavailability determination, and more recently, assessment of drug-target binding as a biomarker of response to chemotherapy. Combining AMS with complementary capabilities such as high performance liquid chromatography (HPLC) can maximize data within a single experiment and provide additional insight when assessing drugs and toxins, such as metabolic profiling. Recent advances in the AMS technology at Lawrence Livermore National Laboratory have allowed for direct coupling of AMS with complementary capabilities such as HPLC via a liquid sample moving wire interface, offering greater sensitivity compared to that of graphite-based analysis, therefore enabling the use of lower <sup>14</sup>C and chemical doses, which are imperative for clinical testing. The aim of this review is to highlight the recent efforts in human studies using AMS, including technological advancements and discussion of the continued promise of AMS for innovative clinical based research.
Optimizing Nano-silver Formation by Fusarium oxysporum PTCC 5115 Employing Response Surface Methodology (2008)

<i>Fusarium oxysporum</i> was grown in medium containing malt, yeast extracts and glucose on shaker at 25&plusmn;1&deg;C and180 rpm for 96 h. The mycelia were used to convert silver nitrate solution into nano-silver. The bioconversion was optimized through response surface methodology-central composite design .The factors which affected the process were pH, temperature, agitation rate, concentration of silver nitrate, time of reaction and weight of <i>Fusarium oxysporum</i> mass. The R<sup>2</sup> was calculated to be 98% indicating the accuracy and ability of the polynomial model to be suitable and reasonable. Positive coefficient of the factors like concentration of silver nitrate solution (E) and weight of <i>Fusarium oxysporum</i> biomass (F), quadratic terms A<sup>2</sup>, B<sup>2</sup>, F<sup>2</sup> and interaction term BC affected linearly formation of nano-silver whereas negative coefficient of pH(A), temperature (B), rate of agitation(C), time(D) along with quadratic terms C<sup>2</sup>, D<sup>2</sup>, E<sup>2</sup>, and interaction terms such as BF decreased the nano-silver formation.
Breast Conservation in the Treatment of Breast Cancer (2001)

Increased use of breast conservation in our community practice parallels the national trend, with similar treatment results. Our findings suggest the successful integration of research-proven innovations into community practice.
Exercise-Induced Symptomatic and Asymptomatic Myocardial Ischemia in Patients with Severe Coronary Artery Disease (1992)

Journal of Cardiovascular Pharmacology™ is a peer reviewed, multidisciplinary journal that publishes original articles and pertinent review articles on basic and clinical aspects of cardiovascular pharmacology. Appropriate subjects include new drug development and evaluation, physiological and pharmacological bases of drug action, metabolism, drug interactions and side effects, clinical results with new and established agents and novel methods. The focus is on pharmacology in its broadest applications, incorporating not only traditional approaches, but new approaches to the development of pharmacological agents and the prevention and treatment of cardiovascular diseases.
Model structure for a bituminous coal (1980)

The model coal molecule described in this paper is presented with the following objectives: (1) to incorporate into the model new structural information that has become available in recent years; (2) to derive additional input data for the model molecule by means of a mathematical analysis; and (3) to test the model by comparing the experimentally observed behavior of a high-volatile bituminous coal in a number of chemical reactions with the expected behavior of the model molecule in the same reactions.
Computation observability regions for discrete-time hybrid systems (2004)

In this paper we focus on observability for hybrid systems in the mixed-logic dynamical form. We show that the maximal set of observable states, that is usually nonconvex and disconnected, can be represented as the union of finitely many polytopic regions. The argument, which is based on multi-parametric programming theory, is constructive and provides an algorithm for the computation of the regions.
Enzyme-Catalyzed Synthesis of Water-Soluble (2016)

An environmentally friendly water-soluble conjugated polythiophene poly(2-(3-thienyl)- ethoxy-4-butylsulfonate) (PTEBS) has been found to be effective for making hybrid solar cells. In this work, we first report the enzyme-catalyzed polymerization of (3-thienyl)-ethoxy-4-butylsulfonate (TEBS) using horseradish peroxidase (HRP) enzyme as a catalyst and hydrogen peroxide (H2O2) as an oxidant in an aqueous buffer. This enzyme-catalyzed polymerization is a synthesis process for the synthesis of water-soluble conjugated PTEBS, the benefits of which include a simple setting, high yields, and an environmentally friendly route. Fourier transform infrared spectra (FTIR) and UV-Vis absorption spectra confirm the successful enzyme-catalyzed polymerization of TEBS. The thermo gravimetric (TG) data show the obtained PTEBS is stable over a fairly high range of temperatures. The present PTEBS has a good solubility in water and ethanol, and photoluminescence quenching of PTEBS/titanium dioxide (TiO2) composite implies that the excitons dissociate and separate successfully at the interface of PTEBS and TiO2, which help to build solar cells using green processing methods.
Préparation et Caractérisation d'Hétéropolymères Greffés (1968)

Abstract An anionic grafting process that operates by means of a reaction between a carbanionic endgroup of a living polymer and an electrophilic grouping located on another polymer chain has been applied to the synthesis of graft copolymers of extremely high molecular weights. The polymers obtained have been characterized and fractionated. Their radii of gyration are small compared with those of linear macromolecules of the same molecular weight but higher than those of the backbone chain from which they derive. The same method has been applied to the synthesis of heterograft polymers; in that case a three‐block copolymer is chosen as backbone, the two outer blocks bearing electrophilic groupings. The grafting degrees which were reached here are higher than those obtained in the case of homopolymeric backbones. Nevertheless, fluctuations in composition and polydispersities remain of the same order of magnitude. The highly branched structure of the macromolecules obtained is shown by viscosimetric measurements and by the retention times of gel permeation chromatography. The “viscosimetric volumes” of the solvated particles are correctly located on the GPC calibration curve.
The phenolic <i>vir</i> gene inducer ferulic acid is O‐demethylated by the VirH2 protein of an <i>Agrobacterium tumefaciens</i> Ti plasmid (1999)

Some or possibly all Ti plasmids of Agrobacterium tumefaciens encode a bicistronic operon designated virH , which encodes two proteins, VirH1 and VirH2, that resemble a family of cytochrome P450‐type monooxygenases. Expression of this operon is induced by a family of phenolic compounds that induce all other operons within the vir regulon. We hypothesized that either or both of these proteins might metabolize some or all of these phenolic compounds. We therefore tested induction of a vir promoter by a variety of phenolic compounds in isogenic strains that express or lack virH1 and virH2 . Although some compounds were equally effective inducers regardless of the virH status, other compounds induced vir expression far more effectively in the virH mutant than in the virH ‐proficient host. For all tested compounds, VirH2 appeared to be solely responsible for this effect. One such compound, ferulic acid, was chosen for biochemical analysis. Ferulic acid was degraded by a VirH‐proficient host but not by a VirH mutant. The wild‐type strain released large amounts of a more hydrophilic compound into the cell supernatant. This compound was tested by mass spectroscopy, nuclear magnetic resonance and UV spectroscopy and found to consist of caffeic acid. This indicates that wild‐type strains convert virtually all added ferulic acid to caffeic acid, and that VirH2 is essential for this O‐demethylation reaction. Ferulic acid was far more toxic than caffeic acid to the wild‐type strain, although the wild‐type strain was more resistant to ferulic acid than was the virH mutant. Caffeic acid was slowly removed from the broth, suggesting further metabolic reactions.
Reply (2015)

aDept. of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada bDepts. of Pediatrics and Psychology and Neuroscience, and Centre for Pediatric Pain Research, IWK Health Centre, Dalhousie University, Halifax, NS, Canada E-mail address: [email protected] (J. S. Mogil)
Influence of molecular structure on optical absorption spectra of solvated electrons in alcohols (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of molecular structure on optical absorption spectra of solvated electrons in alcoholsRobert R. Hentz and Geraldine A. Kenney-WallaceCite this: J. Phys. Chem. 1974, 78, 5, 514–519Publication Date (Print):February 1, 1974Publication History Published online1 May 2002Published inissue 1 February 1974https://pubs.acs.org/doi/10.1021/j100598a011https://doi.org/10.1021/j100598a011research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
An experimental technique for tracking dolphins in the vicinity of a trawl net (1995)

The system described in this paper provides a means of tracking one or more echolocating cetaceans (dolphins, porpoises and whales) in three-dimensional space. The aim of the research is to enable the behaviour of cetaceans to be observed passively in the wild in the vicinity of a large trawl net and to evaluate the effectiveness of deterrents intended to prevent the by-catch of these animals.
Dynamic bootstrapped shift register for smart sensor arrays (2005)

In this paper we demonstrate the operation of a dynamic serial-to-parallel shift register, with only four transistors per stage. A bootstrap capacitor is used to overcome the problem of transistor threshold voltage drop. We will refe rt ot his new logic family as non-ratioed bootstrap logic (NRBL). Simulation results are presented showing the operation of the shift register along with Monte Carlo analysis to demonstrate the robustness of the circuit. A key application area for this novel shift register is in the addressing and read out of high-density smart sensor arrays.
Pupillary Response to Noxious Stimulation During Isoflurane and Propofol Anesthesia (1993)

We studied the effects of noxious stimuli on arterial blood pressure, heart rate, pupil size, and the pupillary light reflex in 13 volunteers anesthetized with either isoflurane or propofol. Those given isoflurane (n = 8) were anesthetized twice, in a randomly selected order, once at an end-tidal concentration of 0.8% and once at 1.2%. An intense noxious stimulus was provided by electrical stimulation applied to skin of the abdominal wall (65-70 mA, 100 Hz). Hemodynamic values and pupillary responses were recorded immediately before stimulation and at 15-60-s intervals during 8 subsequent min. In the volunteers given isoflurane (both concentrations), stimulation significantly increased pupil size (265 +/- 44%) and the amplitude of the light reflex (233 +/- 23%). In contrast, mean heart rate and systolic blood pressure increased only 19 +/- 7% and 13 +/- 7% after stimulation. Five additional volunteers were anesthetized twice with propofol (approximately 3 micrograms/mL plasma concentration) and 60% nitrous oxide. The same electrical stimulus was applied, and hemodynamic and pupillary measurements were obtained. During one propofol anesthetic, an esmolol infusion (100 micrograms.kg-1 x min-1) was started 10 min before stimulation to determine whether this agent would blunt the pupillary response. The pupillary light reflex increased more than 200% during both propofol anesthetics with or without esmolol; once again, heart rate and blood pressure changed little. We conclude that with these experimental conditions, the pupil is a more sensitive measure of noxious stimulation than the commonly used variables of arterial blood pressure and heart rate.
Vasopressin signal transduction in rat type II pneumocytes (1990)

Previous studies demonstrate that in cultured type II pneumocytes, [Arg8]-vasopressin (AVP) stimulates surfactant secretion independent of adenosine 3',5'-cyclic monophosphate (cAMP). In the current study AVP stimulated a 50% loss of radioactive phosphatidylinositol 4,5-bisphosphate (PIP2) within 15 s. Consistent with AVP-induced PIP2 hydrolysis was an increased appearance of the two breakdown products 1,2-diacylglycerol (1,2-DAG) and inositol 1,4,5-trisphosphate (IP3). Also, AVP stimulated the appearance of radiolabel in phosphatidic acid (PA) suggesting that the conversion of 1,2-DAG to PA could be used for PIP2 resynthesis. The effects of AVP on PIP2 and IP3 were mimicked by the bioactive AVP fragment and inhibited by the specific AVP1 antagonist. The EC50 for AVP on IP3 production was 6 nM. AVP stimulated protein kinase C (PK-C) activity twofold over the basal activity of 0.74 +/- 0.07 nmol P.min-1.mg protein-1 but did not activate cAMP-dependent protein kinase activity. The AVP1 antagonist inhibited AVP activation of PK-C. Therefore, activation of the AVP1 receptor resulted in PIP2 hydrolysis for signal transduction, PK-C activation, and surfactant secretion.
Quantification of Immunosuppression by Flow Cytometry in Stable Renal Transplant Recipients (2003)

The current standard of monitoring transplant patients by drug levels is not optimal because it does not take into account the different and individual effects of immunosuppressive drugs on each patient. In this study, the authors tested immune function assays for monitoring transplant patients. Blood was collected from stable renal transplant patients treated with cyclosporin, mycophenolate mofetil, and prednisone (n = 8), and from healthy volunteers (n = 12). Lymphocyte proliferation, expression of T-cell surface activation antigens (CD25, CD71, CD11a, CD95, CD154), production of intracellular cytokines (IL-2, INFgamma, TNFalpha), and lymphocyte subsets (CD4, CD8, CD16, CD20) were assessed by flow cytometry. Lymphocyte proliferation, expression of T-cell surface activation antigens, and production of intracellular cytokines were significantly decreased in transplant recipients compared with healthy control volunteers. The combined effects of several immunosuppressive drugs in renal transplant recipients can be quantitated with immune function assays in whole blood. This new method may be helpful to achieve an optimal level of immunosuppression for each patient.
Chapter 12. Organometallic chemistry. Part (i) The transition elements (1983)

M. Bochmann, R. A. Head and M. D. Johnson, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 1983, 80, 273 DOI: 10.1039/OC9838000273
Haemodialysis as a model for studying endogenous plasma DNA: oligonucleosome-like structure and clearance (1992)

The rate of clearance of extracellular plasma DNA in man has important implications for pathogenetic mechanisms in systemic lupus erythematosus (SLE), as well as for certain other clinical states. Present knowledge of this parameter is derived exclusively from studies of injected, naked DNA in animals. Recent information indicates that the physiologic form of plasma DNA in SLE is that of oligonucleosome-like molecules rather than of naked DNA and consists of multimeric complexes of DNA bound to histone, probably arising from an apoptotic process. In order to study the rate at which these oligonucleosome-like complexes are removed from plasma and to do so in man rather than experimental animals, we exploited the observation that during haemodialysis large amounts of DNA are released, apparently within the dialysis coil, into the patient's plasma. Since this release appears to cease promptly with termination of the procedure, it offered the potential for estimating the rate of removal of such DNA from human plasma. Moreover, if that DNA, as postulated, were shown to possess an oligonucleosome-like structure resembling that found endogenously in human SLE, the relevance of such information to the human disease state would be further enhanced. The present results support the conclusion that DNA released into plasma during haemodialysis possesses such an oligonucleosome-like structure. The plasma half-life of that DNA in man was found not to exceed 4 min. The highly dynamic state thus implied for extracellular endogenous plasma DNA in man has important implications for pathogenetic mechanisms dependent on dsDNA in SLE. Moreover, individuals undergoing chronic haemodialysis, who are thereby exposed to a very large cumulative amount of such DNA, might serve as models for studying its long-term sequelae.
A cluster of high psychological and somatic symptoms in children with idiopathic scoliosis predicts persistent pain and analgesic use 1 year after spine fusion (2018)

Findings from this exploratory study suggest a need to comprehensively assess children with scoliosis for preoperative signs and symptoms that may indicate an underlying vulnerability for persistent pain. This, in turn may help guide a comprehensive perioperative treatment strategy to mitigate the potential for long-term pain trajectories.
On the Significance of Chinese Culture in English Teaching (2013)

The choice and expression of culture plays an important role which can't be ignored in teaching.It is helpful not only for learners to understand the nature and purpose of learning,enhance the sense of identity to motherland and mother tongue but also for our country to integrate with the whole world.Facing the problem of deficiency of culture in teaching,many ways have been raised such as learning Chinese English which has characteristics,adding more culture in curriculum,English textbooks and teaching methods,as well as improving teachers' inner quality and their senses of responsibility to infiltrate culture.
COMPATIBILITY OF VAPOR DEPOSITED B, SIC, AND TIB2 FILAMENTS WITH SEVERAL TITANIUM MATRICES (1968)

Abstract : The filament-matrix compatibility was evaluated for B, SiC, and TiB2 vapor deposited filaments with high purity, commercial purity titanium, and Ti- 6Al-4V. Filament-matrix diffusion sandwiches were prepared by solid state resistance bonding. These samples were subsequently heated at 800-991C for times of 1-100 hours. The reaction rates and reaction products were evaluated using light microscopy, electron replicas, microhardness measurements, and microprobe analysis. The order of decreasing filament-matrix interaction was B, SiC, and TiB2 in each of the three materials. High purity Ti, commercial purity Ti, and Ti-6Al-4V is the order of decreasing reactivity with the filaments after 100 hours at 850-991C. The reaction of B with unalloyed titanium is characterized as the formation of a TiB2 layer adjacent to the filament with an external acicular TiB layer. The reaction layers were formed by the predominately outward diffusion of the boron as evidenced by the lack of recession of the initial filament diameter and the void formation in the filament. The interaction of B with Ti-6Al-4V is characterized by the formation of TiB2 with the rejection of Al ahead of the advancing TiB2 front which stabilizes the alpha-titanium phase around the TiB2 reaction layer. The SiC filament reacts with titanium to form a multi-phased reaction layer. The SiC-Ti interaction takes place by the simultaneous growth inward and outward of the reaction zone. A uniform distribution of 0.1 weight percent titanium was observed in the SiC filament after 100 hours at 850C. The TiB2 filament reacted with titanium to form a TiB layer adjacent to the filament.