gebhart/patrepeval huggingface dataset:
Continuous Left Ventricular Ejection Fraction Monitoring by Central Aortic Pressure Waveform Analysis (2006)

Left ventricular ejection fraction (EF) is perhaps the most clinically significant index of global ventricular function. EF is measured in clinical practice via imaging methods such as echocardiography. However, these methods generally require a well-trained operator and expensive capital equipment. Thus, EF measurements are only obtained in the clinical setting and are usually made few and far between. To expand the measurement of this critical hemodynamic variable, our overarching hypothesis is that EF may be continuously (i.e., automatically) monitored by mathematical analysis of routinely measured blood pressure waveforms. Here, we introduce a novel technique for estimating the absolute EF by model-based analysis of only a central aortic pressure (CAP) waveform. We then demonstrate the validity of the technique with respect to five conscious dogs in which reference EF was independently measured before and after chronic pacing induced heart failure. With further successful testing, the technique may potentially be utilized for continuous EF monitoring in research and clinical settings in which an aortic catheter is employed as well as for ambulatory EF monitoring in conjunction with recently developed implantable devices for measuring CAP
Quantitative coronary angiography: measurement of the "critical" stenosis in patients with unstable angina and single-vessel disease without collaterals. (1979)

Quantitative angiographic assessment of proximal coronary artery stenosis was performed in 15 patients with consecutive presentations in two categories defined by clinical and angiographic criteria. Group 1 consisted of 10 patients who had new onset of refractory rest angina and ischemic ST-T changes, but no infarction, single-vessel coronary disease without collateralization, and normal left ventricular (LV) angiograms. Group 2 consisted of five patients who were similar to patients in group 1, but had subendocardial infarction (SEI). Quantitative coronary arteriography, using paired perpendicular angiographic views and digital computation, yielded statistically different lesion dimensions and hemodynamic predictions for the two groups. Minimum stenosis diameters were 0.88 +/- 0.14 (SD) and 0.64 +/- 0.08 mm, respectively, for groups 1 and 2. This corresponded to 72% and 78% diameter reduction and 92% and 95% cross-sectional area reduction for the two groups. These small dimensional differences among lesions in the two groups resulted in large differences in their hemodynamic impact as predicted from classic fluid mechanics theory. We conclude that there are characteristic lesion dimensions for the isolated "critical" stenosis in these selected patients with rest angina. Further small increases in lesions severity result in SEI. Certain practical applications and limitations of these observations are discussed.
Dye-Ligand Chromatography (2003)

The affinity of two kinases for Blue Dextran was discovered in 1968 during gel permeation chromatography (1) and agarose electrophoresis (2). The observed interaction was mediated by the chromophore of Blue Dextran, Cibacron Blue F3G-A (3), which was postulated to bind to the supersecondary structure of certain enzymes known as the dinucleotide fold (4). Immobilized Cibacron Blue F3G-A replaced more expensive biological group-specific ligands in the affinity chromatographic purification of a wide variety of nucleotide-binding enzymes (5). The adsorbent was easier to synthesize, biochemically more stable, and had much higher capacities than the traditional nucleotide-based affinity matrices, making it more suitable for large-scale purifications.
The Use of Cyclic Bifunctional Protecting Groups in Oligosaccharide Synthesis (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A method of acoustic landmark extraction for mobile robot navigation (1996)

Describes a method to extract multiple acoustic landmarks for the indoor navigation of a mobile robot. The environment is modeled by specular vertical walls. An ultrasonic sensor mounted on the mobile robot scans around the surrounding walls and detects multiple echo pulses. On the horizontal plane at the height of the ultrasonic sensor from the floor, the two-dimensional environment is described by the distance as a function of angle in the scan. Due to the specularity of the walls, the distance function has a manageable number of retroreflective parts that can be used as landmarks. By virtue of the constancy of the relative positions between the ultrasonic sensor and the walls in scanning, the echo pulses reflected from a certain reflection points (RP) have the same time-of-flight in the ultrasonic scan data. The authors determine the position of an RP from the collection of the echo pulses that have the same time-of-flight. The direction to an RP is estimated from the orientation of the ultrasonic sensor at which the maximum magnitude is obtained for the group of echo pulses that correspond to the RP. The mean time-of-flight of the group of echo pulses provides the distance to the RP. Some experimental results are provided to show the validity and the performance of the proposed method.
Transient Association of the First Intermediate during the Refolding of Bovine Carbonic Anhydrase B (1992)

Many proteins which aggregate during refolding may form transiently populated aggregated states which do not reduce the final recovery of active species. However, the transient association of a folding intermediate will result in reduced refolding rates if the dissociation process occurs slowly. Previous studies on the refolding and aggregation of bovine carbonic anhydrase B (CAB) have shown that the molten globule first intermediate on the CAB folding pathway will form dimers and trimers prior to the formation of large aggregates (Cleland, J. L.; Wang, D. I. C. Biochemistry 1990, 29, 11072-11078; Cleland, J. L.; Wang, D. I. C. In Protein Refolding; Georgiou, G., De-Bernardez-Clark, E., Eds.; ACS Symposium Series 470; American Chemical Society: Washington, DC, 1991; pp 169-179). Refolding of CAB from 5 M guanidine hydrochloride (GuHCl) was achieved at conditions ([CAB]f = 10-33 microM, [GuHCl]f = 1.0 M) which allowed complete recovery of active protein as well as the formation of a transiently populated dimer of the molten globule intermediate on the refolding pathway. A kinetic analysis of CAB refolding provided insight into the mechanism of the association phenomenon. Using the kinetic results, a model of the refolding with transient association was constructed. By adjusting a single variable, the dimer dissociation rate constant, the model prediction fit both the experimentally determined active protein and dimer concentrations. The model developed in this analysis should also be applicable to the refolding of proteins which have been observed to form aggregates during refolding. In particular, the transient association of hydrophobic folding intermediates may also occur during the refolding of other proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
Transparent recovery in distributed systems (position paper) (1991)

article Free Access Share on Transparent recovery in distributed systems (position paper) Author: David F. Bacon View Profile Authors Info & Claims ACM SIGOPS Operating Systems ReviewVolume 25Issue 2April 1991 pp 91–94https://doi.org/10.1145/122120.122130Online:01 April 1991Publication History 4citation108DownloadsMetricsTotal Citations4Total Downloads108Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Experimental demonstration of compact torus compression and acceleration (1991)

Tests of compact torus (CT) compression on the RACE device [Phys. Rev. Lett. 61, 2843 (1988)] have successfully demonstrated stable compression by a factor of 2 in radius, field amplification by factors of 2–3 to 20 kG, and compressed densities exceeding 1016 cm−3. The results are in good agreement with two-dimensional magnetohydrodynamic simulations of the CT dynamics. The CT is formed between a pair of coaxial conical conductors that serve as both a flux conserver for stable, symmetric formation and as electrodes for the compression and acceleration phases. The CT is compressed by J×B forces (poloidal current, toroidal field) when a 120 kV, 260 kJ capacitor bank is discharged across the electrodes. The CT reaches two-fold compression to a radius of 8 cm and a length of 20–30 cm near the time of peak current, 10 μsec (many Alfvén times) after the accelerator fire time, and is subsequently accelerated in a 150 cm straight coaxial section to velocities in the range 1.5–6.5×107 cm/sec. A new set of acceleration/focusing electrodes 740 cm in length are projected to give an additional factor of 3 in radial compression with final velocities of 1–3×108 cm/sec (similar to previously achieved on RACE) and incident power densities of a few ×1011 W/cm2. Compact torus accelerators scaled to multimegajoules have the potential to achieve unprecedented plasma velocities and power densities with many applications in high-energy-density physics.
Iron Regulatory Proteins Control a Mucosal Block to Intestinal Iron Absorption (2013)

Mammalian iron metabolism is regulated systemically by the hormone hepcidin and cellularly by iron regulatory proteins (IRPs) that orchestrate a posttranscriptional regulatory network. Through ligand-inducible genetic ablation of both IRPs in the gut epithelium of adult mice, we demonstrate that IRP deficiency impairs iron absorption and promotes mucosal iron retention via a ferritin-mediated "mucosal block." We show that IRP deficiency does not interfere with intestinal sensing of body iron loading and erythropoietic iron need, but rather alters the basal expression of the iron-absorption machinery. IRPs thus secure sufficient iron transport across absorptive enterocytes by restricting the ferritin "mucosal block" and define a basal set point for iron absorption upon which IRP-independent systemic regulatory inputs are overlaid.
K-edge digital subtraction arthrography of the painful hip prosthesis: a feasibility study. (1990)

K-edge energy subtraction radiography is a method for detecting the presence of iodinated contrast material by subtracting two digital radiographs produced by X-ray beams with energies above and below the iodine K edge. We performed a feasibility study on the application of K-edge energy digital subtraction arthrography (KEDSA) to painful hip prostheses. During arthrography, loosening of the prosthesis is implied if contrast material is seen dissecting around the prosthesis, an often difficult detection task because of adjacent prosthesis metal or cement. In conventional arthrography a preliminary mask image is thus used from which films obtained after injection of iodinated contrast material are subtracted. Movement by the patient during this process may preclude subsequent subtraction. With KEDSA, since multiple image pairs may be obtained after the injection of contrast material, the problem of patient motion is virtually eliminated. A conventional X-ray tube operating between 55 and 65 kVp was alternately filtered by iodine and cerium filters to produce the KEDSA images. The apparatus was capable of producing a subtracted image within 3 sec. The technique was applied to phantoms and to six patients immediately after hip arthrography that had been positive for prosthesis loosening. Although of lower spatial resolution, the KEDSA images were, in all cases, positive for loosening in a pattern consistent with the conventional arthrographic images. KEDSA was shown to be successful in detecting extraarticular contrast material. During a single study, subtraction in various imaging planes as well as postexercise subtraction imaging can be accomplished-techniques not heretofore possible in routine subtraction arthrography.
Practical method for optimizing radioimmunoassay detection and precision limits (1991)

A model of the competitive radioimmunoassay standard curve, based on the Law of Mass Action, has been developed and used in conjunction with experimental and counting errors to predict the assay detection limit and precision profiles. We verified the model with hapten radioimmunoassays performed in our laboratory. The resulting computer program can be used to determine the optimum antiserum concentration--depending on its affinity--and labeled-antigen concentration--according to its specific activity and nonspecific binding. The graphical representation of this model provides radioimmunologists with a practical tool for assay optimization.
Effect of Adrenalectomy on<i>In Vivo</i>Glucose Metabolism in Insulin Resistant Zucker Obese Rats (1986)

Lean (Fa/?) and obese (fa/fa) Zucker rats were adrenalectomized (ADX) in order to assess the contribution of adrenal hormones to insulin resistance of the obese Zucker rat. Glucose utilization was measured using an insulin suppression test. Sham-operated obese rats gained almost twice as much weight as sham-operated lean littermates. However, body weight gain of ADX animals was comparable in both genotypes. It was significantly less than that of the respective sham-operated controls. Body weight differences can be accounted for almost entirely by a marked loss of adipose tissue. Although insulin resistance may be attributable to obesity in part, steroid hormones are thought to be directly antagonistic to insulin for glucose metabolism. Adrenalectomy resulted in a decrease in serum glucose concentrations for both lean and obese Zucker rats compared with their respective sham-operated groups. Serum insulin concentration of lean ADX rats was 23% of sham-operated controls; in obese ADX rats, it was 9% of controls. Elevated levels of steady state serum glucose (SSSG) levels in sham-operated obese rats demonstrate a marked resistance to insulin induced glucose uptake compared with sham-operated lean animals. Adrenalectomy caused a marked improvement in insulin sensitivity of obese rats. The hyperglycemic SSSG levels of the obese rats were reduced 2.5 times by ADX. These results indicate that insulin resistance of Zucker obese rats can be ameliorated by ADX, suggesting adrenal hormones contribute to insulin resistance in these animals.
Subclass Distribution of IgA and IgG Antibodies Against Clq in Patients with Rheumatic Diseases (1995)

To obtain insight into the immunoregulatory mechanisms in patients with different rheumatic diseases, the occurrence and the subclass distribution of IgA and IgG antibodies against Clq (anti-ClqAb) was determined. In patients with systemic lupus erythaematosus (SLE) the highest frequency of increased serum levels of IgG anti-ClqAb were found, whereas IgA anti-ClqAb were predominantly present in patients with ankylosing spondylitis (AS) and patients with rheumatoid arthritis complicated by vasculitis (RV). In all the IgA anti-ClqAb positive AS and RV patients the antibody reactivity involved the IgA1 subclass while the IgA2 subclass was found in 47% of the patients. Further characterization of the IgA anti-Clq binding activity in sera of AS patients revealed that both subclasses of IgA anti-ClqAb were predominantly polymeric; the binding of both IgA subclasses with solid phase Clq was inhibitable by aggregated fluid phase Clq; we found no detectable interference of rheumatoid factor in the test system for the measurement of IgA anti-ClqAb. In patients with SLE the IgG anti-ClqAb reactivity was mainly of the IgG2 and IgG3 subclass, whereas in the same patients the IgG anti-tetanus toxoid response was not restricted to these subclasses. The predominance of IgG2 and IgG3 subclass of anti-ClqAb in sera of SLE patients, suggests a skewing of the anti-ClqAb response. The observation that the IgA anti-ClqAb of both subclasses is predominantly polymeric in nature and the notion that polymeric IgA is associated with activation of inflammation cascades, suggests that IgA anti-ClqAb may contribute to tissue damage.
Nonalcoholic fatty liver disease and measures of early brain health in middle‐aged adults: The CARDIA study (2017)

NAFLD is negatively associated with early brain health as assessed by MR measures of structure (TTV) and perfusion (GM-CBF). BMI and VAT attenuated this relationship, providing insight into the potential metabolic role of liver fat in brain health and disease.
Toward Safer Treatment Options for Advanced Keratoconus (2015)

Keratoconus is a bilateral and progressive corneal disease characterized by a significant increase in irregular astigmatism and corneal thinning. Numerous treatments—including penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), ultraviolet-crosslinking (UV-CXL), and intracorneal ring segments—are available for halting progression and/or obtaining (partial) visual rehabilitation. Recently, midstromal Bowman layer transplantation has been introduced as a new treatment option for advanced keratoconus. This technique has shown significant promise in halting disease progression and postponing riskier procedures such as PK or DALK.
Studies of cyclodextrin inclusion complexes. I. Complex between cyclodextrins and bencyclane in aqueous solution. (1984)

Bencyclane (Ben) inclusion complexes with α-, β-, and γ-cyclodextrins (CyD's) in aqueous solution were studied by ultraviolet (UV), circular dichroism (CD), and nuclear magnetic resonance (NMR) spectroscopic methods. The composition ratio, the formation constants (K values), and the thermodynamic parameters for the three complexes were determined by analysis of the UV and CD spectra. The results indicated that CyD formed a 1 : 1 complex with Ben in all three cases, though the K values differed greatly (β>γ≫α). From the thermodynamic parameters obtained from the temperature dependence, it was concluded that the primary driving force for the complex formation is van der Waals interaction in the case of α- and β-CyD complexes, while it is hydrophobic interaction for the γ-CyD complex. Probable structures of the three complexes are discussed mainly on the basis of NMR data. It was concluded that the aromatic ring of Ben is inserted into the cavity of CyD from the small-diameter side in the case of β-or γ-CyD complexes, and from the opposite side in the case of α-CyD complex. It is highly probable that, in the case of β-CyD complex, binding is tight over the whole aromatic ring; in the case of γ-CyD complex, loose binding takes place over most of the aromatic ring and in the neighborhood of the benzyl carbon, with the para position of the aromatic ring extruding from the cavity; in the case of α-CyD complex, only partial inclusion occurs around the para position of the aromatic ring.
An adaptive FET sizing technique for high efficiency thermoelectric harvesters (2016)

A theoretical analysis of losses in low power thermoelectric harvester interfaces is used to find expressions for properly sizing the power transistors according to the input voltage level. These expressions are used to propose an adaptive FET sizing technique that tracks the input voltage level and automatically reconfigures the converter in order to improve its conversion efficiency. The performance of a low-power thermoelectric energy harvesting interface with and without the proposed technique is evaluated by circuit simulations under different input voltage/power conditions. The simulation results show that the proposed technique improves the conversion efficiency of the energy harvesting interface up to 12% at the lowest input voltage/power levels.
Aqueous-Core Capsules via Interfacial Free Radical Alternating Copolymerization (2006)

Aqueous-core capsules with uniform polymeric shells and diameters ranging from 0.2 to 5 μm were prepared by polymerizing the interfaces of inverse emulsion microspheres. Free-radical polymerization was constrained to the interface of water-in-oil microspheres by the alternating copolymerization of hydrophobic maleate esters and hydrophilic polyhydroxy vinyl ethers, in a manner analogous to classical interfacial polycondensations. In these polymerizations, the kinetics, shell thickness, and release characteristics of the resulting aqueous-core capsules are set by the diffusion-limited alternating reaction of the oil-soluble maleate esters and water-soluble vinyl ethers.
Optics Design and Beam Dynamics Simulation for a VHEE Radiobiology Beam Line at PRAE Accelerator (2019)

The Platform for Research and Applications with Electrons (PRAE) is a multidisciplinary R facility gathering subatomic physics, instrumentation, radiobiology and clinical research around a high-performance electron accelerator with beam energies up to 70 MeV. In this paper we report the complete optics design and performance evaluation of a Very High Energy Electron (VHEE) innovative radiobiology study, in particular by using Grid mini-beam and FLASH methodologies, which could represent a major breakthrough in Radiation Therapy (RT) treatment modality.
Analysis of Injury Severity Outcomes of Highway Winter Crashes: A Multi-level Modeling Approach (2012)

This paper presents a multilevel modeling framework for relating the injury severity of winter road collisions to various influencing factors such as weather and surface conditions, traffic conditions, road design and vehicle and driver characteristics. Thirty one road sections from across the province of Ontario, Canada were selected for this analysis, each representing an actual patrol route covered by a specific maintenance yard. Collisions over a period of six years (2000-2006) were analyzed using multilevel logistic regression for the conditional probability of a collision resulting in one of the pre-defined severity levels. Three levels of aggregation were considered for the data, namely: occupant based, vehicle based and collision based. It was found that a multilevel multinomial unordered logit model has a better fit to the data than multilevel sequential binary logistic models and multilevel multinomial ordered logit models. Furthermore it was found that results obtained from occupant based data are more reliable than vehicle and collision based data. It was found that factors related to drivers (age, sex, action, condition), collision impact location, road characteristics (condition, alignment, number of lanes), vehicle data (age, type, condition, manoeuvre, number), personal choices (position in vehicle, safety equipment used), weather conditions (precipitation type & intensity, temperature, wind speed, visibility), day of the week, lighting, speed limit, traffic volume and road surface conditions have statistically significant effects on collision severity outcome. In general, results indicate that poor weather, road surface conditions, high traffic volume, young and male drivers, new vehicles and good lighting conditions are associated with injury severity levels.
SRv6 NET-PGM extension: Insertion (1999)

Traffic traversing an SR domain is encapsulated in an outer IPv6
header for its journey through the SR domain. To implement transport
services strictly within the SR domain, the SR domain may require
insertion or deletion of an SRH after the outer IPv6 header of the SR
domain. Any segment within the SRH is strictly contained within the SR
domain. This document extends SRv6 Network Programming [I-D.ietf-
spring-srv6-network-programming] with new SR endpoint and transit
behaviors to be performed only within the SR domain in any packet
owned by the domain.