gebhart/patrepeval huggingface dataset:
Technical Note: An R package for fitting Bayesian regularized neural networks with applications in animal breeding1 (2013)

In recent years, several statistical models have been developed for predicting genetic values for complex traits using information on dense molecular markers, pedigrees, or both. These models include, among others, the Bayesian regularized neural networks (BRNN) that have been widely used in prediction problems in other fields of application and, more recently, for genome-enabled prediction. The R package described here (brnn) implements BRNN models and extends these to include both additive and dominance effects. The implementation takes advantage of multicore architectures via a parallel computing approach using openMP (Open Multiprocessing) for the computations. This note briefly describes the classes of models that can be fitted using the brnn package, and it also illustrates its use through several real examples.
Matching Features Correctly through Semantic Understanding (2014)

Image-to-image feature matching is the single most restrictive time bottleneck in any matching pipeline. We propose two methods for improving the speed and quality by employing semantic scene segmentation. First, we introduce a way of capturing semantic scene context of a key point into a compact description. Second, we propose to learn correct match ability of descriptors from these semantic contexts. Finally, we further reduce the complexity of matching to only a pre-computed set of semantically close key points. All methods can be used independently and in the evaluation we show combinations for maximum speed benefits. Overall, our proposed methods outperform all baselines and provide significant improvements in accuracy and an order of magnitude faster key point matching.
A systematic study of the impedance boundary condition (EM scattering) (1990)

A numerical study of the impedance boundary condition has been carried out with the objective of evaluating its applicability to several representative, planar, two-dimensional (2D) inhomogeneous scatterers. Three basic classes of 2D structures are considered: an infinite-depth trough structure, a finite-depth trough structure, and a linearly tapered trough. These problems were solved using the method of moments in two ways. In the first, a surface integral equation (SIE) approach was used as a baseline and was considered to be a numerically rigorous solution. In the second, the 2D structure was reduced to a 1D structure having an equivalent surface impedance. Results obtained for the three structures are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Growth and optical properties of ferroelectric tungsten bronze crystals (1993)

Abstract The state of the art in the Czochralski growth of various optical-quality ferroelectric tungsten bronze single crystals is reviewed with respect to crystal structure, phase transitions and cationic make-up. Based on our growth of over 25 single crystal bronzes, we have classified these bronzes into four categories having distinctly different ferroelectric and optical characteristics. With the use of this classification, optimal bronzes can be chosen for specific electro-optic and photorefractive applications.
<i>Drosophila coracle</i>, a Member of the Protein 4.1 Superfamily, Has Essential Structural Functions in the Septate Junctions and Developmental Functions in Embryonic and Adult Epithelial Cells (1998)

Although extensively studied biochemically, members of the Protein 4. 1 superfamily have not been as well characterized genetically. Studies of coracle, a Drosophila Protein 4.1 homologue, provide an opportunity to examine the genetic functions of this gene family. coracle was originally identified as a dominant suppressor of EgfrElp, a hypermorphic form of the Drosophila Epidermal growth factor receptor gene. In this article, we present a phenotypic analysis of coracle, one of the first for a member of the Protein 4. 1 superfamily. Screens for new coracle alleles confirm the null coracle phenotype of embryonic lethality and failure in dorsal closure, and they identify additional defects in the embryonic epidermis and salivary glands. Hypomorphic coracle alleles reveal functions in many imaginal tissues. Analysis of coracle mutant cells indicates that Coracle is a necessary structural component of the septate junction required for the maintenance of the transepithelial barrier but is not necessary for apical-basal polarity, epithelial integrity, or cytoskeletal integrity. In addition, coracle phenotypes suggest a specific role in cell signaling events. Finally, complementation analysis provides information regarding the functional organization of Coracle and possibly other Protein 4.1 superfamily members. These studies provide insights into a range of in vivo functions for coracle in developing embryos and adults.
Roles of the Amino Acid Side Chains in the Actin-Binding S-Site of Myosin Heavy Chain1 (1990)

The heptapeptide Ile-Arg-Ile-Cys-Arg-Lys-Gly-OEt is the analog of the S-site, one of the actin-binding sites in myosin [Suzuki et al. (1987) J. Biol. Chem. 262, 11410-11412]. Various substituted heptapeptides were synthesized, and the dissociation constants of each acto-heptapeptide complex was measured. Comparison of the dissociation constants indicated that the hydrophobic side chain of Ile-1 was critical for the binding with F-actin, but not that of Ile-3. The positive charge and the side chain length of Arg-2 were also important. The presence of a sulfur atom in the Cys-4 was also necessary. The affinity of the N-terminal Ile-Arg-Ile part for F-actin was influenced by the kind of residues in the C-terminal tetrapeptide part. Based on these results, the side chains of Ile(702), Arg(703), and Cys(SH1)(705) in myosin subfragment-1 heavy chain were assigned to be critical for the binding with F-actin. The amino acid sequence of S-1 heavy chain containing these critical residues for the S-site from residue number 700 to 717 can be predicted as an analogue of the segment B of the ATP-binding site [Walker et al. (1982) EMBO J. 1, 945-951]. The actin-binding S-site possibly shares a part of the ATP-binding site in myosin. We discuss the possibility that the S-site is an inhibitory site of myosin ATPase and the so-called actin-activation of myosin ATPase is a deinhibition induced by transient binding of F-actin to the S-site.
Cellular Response to Linear and Branched Poly(acrylic acid) (2015)

Poly(acrylic acid-co-sodium acrylate) (PNaA) is a pH-responsive polymer with potential in anticancer drug delivery. The cytotoxicity and intracellular effects of 3-arm star, hyperbranched and linear PNaA were investigated with L1210 progenitor leukemia cells and L6 myoblast cells. Free solution capillary electrophoresis demonstrated interactions of PNaA with serum proteins. In a 72 h MTT assay most PNaAs exhibited a IC50 between 7 and 14 mmol L(-1), showing that precipitation may be a sufficient purification for PNaA dilute solutions. Dialyzed 3-arm star and hyperbranched PNaA caused an increase in L6 cell viability, challenging the suitability of MTT as cytotoxicity assay for PNaA. Fluorescent confocal microscopy revealed merging of cellular lipids after exposure to PNaA, likely caused by serum starvation.
Dennett, Foucault, and the Selection of Memes (1999)

The idea of cultural evolution, coined by Daniel Dennett, suggests we might be able to formulate a Darwinian type of explanation for the adaptive 'tricks' we learn as human beings. The proposed explanation makes use of the idea of memes. That idea is examined and related to semantic units linked to the terms in a natural language. It is agreed with Dennett that these are of pivotal significance in understanding the structure of human cognition. The alternative is then explored to the chaos of worddemons that Dennett appeals to in explaining why and how we think and enter into discursive relations. Beginning with certain thoughts about language games the essay moves on to consider the relations of power and knowledge that shape discursive reality and explain our subjectivities and actions. This leads to a sketch of Foucaultian theory as an advance in the philosophy of mind required to move beyond fairly gestural accounts of psychological explanation to be found in the standard biologically motivated approaches.
Mammalian model study of selective activation of small nerve fibres using biphasic pulses with monopolar electrode (2003)

Biphasic pulse can cause lower electrochemical damage to nerve fibres than uniphasic pulse. A simulation system for studying the electrical properties of mammalian myelinated nerve fibres was built. By use of an asymmetric but charge-balanced biphasic stimulation waveform and monopolar point electrode, the sensitivity of excitation and blocking threshold of nerve fibres to fibre diameter was calculated. The results show that it may be possible to selectively activate smaller mammalian myelinated fibres by use of biphasic pulses.
Richard Müller ‐ Vater der Silicone (2004)

Abstract Mit der Direktsynthese der Vorprodukte für Silicone haben Richard Müller und Eugene Rochow Chemiegeschichte geschrieben und einen ganzen Wirtschaftszweig begründet. Trotz „Nationalpreis”︁ und Professur war der Nonkonformist und „ewige Parteilose”︁ Müller der DDR‐Obrigkeit stets ein Dorn im Auge. Im Juli jährte sich die Gründung seines Instituts für Silicon‐ und Fluorcarbonchemie in Radebeul zum 50. Mal.
Dynamic Analysis of Robotic Manipulator Considering Driving Elements. (1991)

This paper presents a more detailed analysis of manipulator dynamics, in which rotational effects of driving motor on dynamic characteristics of the manipulator are taken into consideration.
Seismic anisotropy observed in upper oceanic crust (1981)

Seismic anisotropy in the upper 1500m. of oceanic basement has been observed by polarization analysis of three‐component borehole seismometer records. The most convincing evidence for the anisotropy is shear wave splitting for explosive sources at four azimuths. Compressional wave particle motion deviations suggestive of anisotropy are also observed but they may be caused by lateral inhomogeneities. The anisotropy was not resolved by travel‐time analysis. The observed velocities and particle motions in the horizontal plane can be modelled to within a standard deviation by assuming a perfectly elastic, homogeneous, anisotropic layer 2 with hexagonal symmetry and a horizontal symmetry axis. The most probable cause of the anisotropy is preferred crack orientation.
High contrast metastructures for light manipulation (2011)

A completely new class of planar optics has emerged using subwavelength metastructures with a large index contrast. Uniform and chirped gratings can be used to create high reflection mirrors, high-Q resonators with surface-normal output, hollow core waveguide, vertical to in-plane waveguide coupler, and focusing reflectors and lenses.
ETHYLENE ABSORPTION BY SOLUTIONS OF COPPER(I) CHLORIDE AND AMINES IN METHANOL (1986)

Abstract N,N,N′,N′-Tetramethylethylenediamine, N,N,N′,N′-tetraethylethylenediamine, and N,N,N′-trimethylethylenediamine are stirred with copper(I) chloride in methanol at a charged molar ratio of unity, resulting in homogeneous solutions of the copper(I) chloride-diamine complexes. The solutions, respectively, absorb 11.0, 4.8, and 11.3 mmol of ethylene at 20 °C under 1 atm.
Multiple recent horizontal transfers of a large genomic region in cheese making fungi (2014)

While the extent and impact of horizontal transfers in prokaryotes are widely acknowledged, their importance to the eukaryotic kingdom is unclear and thought by many to be anecdotal. Here we report multiple recent transfers of a huge genomic island between Penicillium spp. found in the food environment. Sequencing of the two leading filamentous fungi used in cheese making, P. roqueforti and P. camemberti, and comparison with the penicillin producer P. rubens reveals a 575 kb long genomic island in P. roqueforti--called Wallaby--present as identical fragments at non-homologous loci in P. camemberti and P. rubens. Wallaby is detected in Penicillium collections exclusively in strains from food environments. Wallaby encompasses about 250 predicted genes, some of which are probably involved in competition with microorganisms. The occurrence of multiple recent eukaryotic transfers in the food environment provides strong evidence for the importance of this understudied and probably underestimated phenomenon in eukaryotes.
Biochemical basis of hypoxanthine‐guanine phosphoribosyltransferase deficiency in nine families (1987)

The concentration of hypoxanthine-guanine phosphoribosyltransferase (HPRT) cross-reacting material (CRM) was determined in haemolysates and/or lymphoblast lysates from nine patients with complete or partial deficiency of HPRT activity. Two of the patients had the fully developed Lesch-Nyhan syndrome and although they had undetectable HPRT activity, small amounts of CRM were found. HPRT-specific mRNA was not detected in lymphoblast lysates from one of these patients, while lysates from the other had a much reduced concentration. Samples from three patients with less than 0.1% of normal HPRT activity but with minor or no neurological manifestations were also found to contain small amounts of CRM. The other four patients whose HPRT activities ranged from 3 to 10% of normal were found to have CRM concentrations which varied from 26 to 100% of normal. In one patient with a partial deficiency the Km for 5-phospho-alpha-D-ribosyl-1-pyrophosphate was five times normal.
1,4-Dihydroxy-2,5-dioxopiperazines from activated N-hydroxyamino acids (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,4-Dihydroxy-2,5-dioxopiperazines from activated N-hydroxyamino acidsJacobus D. M. Herscheid, J. Hans Colstee, and Harry C. J. OttenheijmCite this: J. Org. Chem. 1981, 46, 16, 3346–3348Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/jo00329a044https://doi.org/10.1021/jo00329a044research-articleACS PublicationsRequest reuse permissionsArticle Views342Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ibuprofen plus codeine, ibuprofen, and placebo in a single- and multidose cross-over comparison for coxarthrosis pain (1992)

The analgesic efficacy of 200 mg ibuprofen plus 30 mg codeine, 200 mg ibuprofen and placebo was investigated in a new analgesic evaluation model using single- and repeated-dose administration. The study was a double-blind randomized cross-over investigation in 26 coxarthrosis patients with persistent pain. After a washout period of at least 2 days with paracetamol available as rescue analgesic, each of the 3 treatments was administered in a total of 6 doses during 24 h. The hourly pain intensity was recorded on a 100-mm visual analogue scale (VAS) for 8 h after the 1st and the 6th dose. The pretreatment VAS score was 31-37 mm. After the 1st dose the 8-h mean pain intensity values were 25, 27, and 26 mm after ibuprofen plus codeine, ibuprofen, and placebo, respectively. Following another 5 doses every 4 h the corresponding values were 10, 17 and 29 mm. Repeated administration of both active drugs reduced the pain intensity significantly. The analgesic efficacy of ibuprofen plus codeine was significantly superior to that of ibuprofen which was, in turn, superior to that of placebo. In conclusion, analgesic efficacy was better differentiated after repeated-dose than after single-dose administration. The present study design was able to differentiate between 200 mg ibuprofen plus 30 mg codeine and 200 mg ibuprofen alone in a relatively small number of patients.
A Terrestrial Multiple-Receiver Radio Link Experiment at 10.7 GHz - Comparisons of Results with Parabolic Equation Calculations (2010)

This work presents the results of a terrestrial multiple-receiver radio link experiment at 10.7 GHz. Results are shown in the form of the power levels recorded at several antennas attached to a receiving mast. Comparisons of the measurement data with theoretical predictions using a parabolic equation technique show that, due to the complex propagation environment of the troposphere in terms of the refractive index of air, closer agreement between measurements and simulations can be achieved during periods of standard refractive conditions.
Coordination failure as a source of congestion in information networks (2003)

Coordination failure, or agents' uncertainty about the action of other agents, may be an important source of congestion in large decentralized systems. The El Farol problem provides a simple paradigm for congestion and coordination problems that may arise with over utilization of the Internet. This paper reviews the El Farol problem and surveys previous approaches, which typically involve complex deterministic learning algorithms that exhibit chaotic-like trajectories. This paper recasts the problem in a stochastic framework and derives a simple adaptive strategy that has intriguing optimization properties; a large collection of decentralized decision makers, each acting in their own best interests and with limited knowledge, converge to a solution that (optimally) solves a complex congestion and social coordination problem. A variation in which agents are allowed access to full information is not nearly as successful. The algorithm, which can be viewed as a kind of habit formation, is analyzed using a weak convergence approach, and simulations illustrate the major results.
Cold thyroid nodule reduction with L-thyroxine can be predicted by initial nodule volume and cytological characteristics. (1996)

In a previous study we demonstrated that a 1-yr treatment with L-T4 induces substantial nodule volume reduction (> or = 50%) in approximately 40% of patients with a benign solitary cold thyroid nodule. The present prospective study investigated whether it is possible to identify, before starting L-T4 treatment, nodules with a high probability to shrink in response to L-T4. We recorded several clinical and cytological features in a continuous series of 42 patients with a cold nodule and related them to the nodule volume response to 1-yr treatment with L-T4. Fisher discriminant analysis showed that a combination of some cytological features (colloid, degenerative changes, cellular hyperplasia, and fibrosis) and initial nodule volume can be used for predicting nodule volume reduction. In fact, although only 33% of all nodules shrank, 62% of colloid nodules and 57% of small degenerative nodules shrank. None of the hyperplastic or fibrotic nodules shrank. These results were validated in a different retrospective series of 46 patients and allowed us to predict nodule reduction in over 80% of the cases.
Quantification of a Meaningful Change in Low Back Functional Impairment (2009)

A meaningful change in P(n) was defined as 0.14.
Gas chromatographic mass spectrometric sequencing of peptides and proteins containing γ-carboxyglutamic acid (1980)

A generally applicable strategy has been developed for the primary sequence determination of peptides and proteins containing gamma-carboxyglutamic acid. The intact peptide or protein is either dissolved in, or allowed to come into vapor phase contact with, 0.05 M DCI and then heated in vacuo at 110 degrees C for several hours. Under these conditions gamma-carboxyglutamic acid quantitatively decarboxylates and incorporates two atoms of deuterium per molecule, resulting in the formation of gamma-dideuteroglutamyl residues. Following enzymatic or acidic degradation of the protein the peptide mixture generated is converted (without further isolation of individual peptides) to the N-trifluoroacetylated, O-trimethylsilylated polyamino alcohols and subsequently analyzed by gas chromatography mass spectrometry. Peptide fragments in which gamma-carboxyglutamic acid was present show sequence ions in their mass spectra corresponding to those of glutamic acid, but shifted upwards by 2 amu. This approach has been used to identify the positions of Gla in a tryptic peptide isolated from blood coagulation factor IX, and is currently being employed in the sequence determination of the Gla-containing bone protein osteocalcin.
Instrumentation System Upgrade Supports Mobile Personalized Healthcare Delivery (2006)

Clinicians and patients need mobile tools to detect ototoxic change early and prevent hearing loss. We report on the development of an upgrade of our existing desktop-based clinical-audiological instrumentation into a mobile instrument platform which efficiently supports personalized ototoxicity monitoring on the hospital wards as well as clinic by a trained clinician. Our new wireless-enabled system also serves as the instrumentation platform for the next phase of our work which is remote healthcare delivery with patient-guided at-home ototoxicity monitoring using an evidence-based individualized SRO protocol
Approach Toward the Total Synthesis of 5-Hydroxyaloin A (2010)

The synthesis of a thiomethyl analogue of 5-hydroxyaloin A has been achieved using benzyne and naphthyne [4 + 2] cycloadditions with substituted furans. A regiocontrolled cycloaddition was achieved using a silicon tether, and a regioselective ring opening was accomplished using a sulfide as a directing group.
Photochemical .alpha. cleavage and free-radical reactions of some deoxybenzoins (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical .alpha. cleavage and free-radical reactions of some deoxybenzoinsH. G. Heine, W. Hartmann, D. R. Kory, J. C. Magyer, C. E. Hoyle, J. K. McVey, and F. D. LewisCite this: J. Org. Chem. 1974, 39, 5, 691–698Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/jo00919a024https://doi.org/10.1021/jo00919a024research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Small Apolipoprotein(a) Size Predicts Mortality in End-Stage Renal Disease (2002)

Small apo(a) size, but not Lp(a) level, independently predicts total mortality risk in dialysis patients.