gebhart/patrepeval huggingface dataset:
The Role of Truncated SOS1 in Acute Lymphoblastic Leukemia (2021)

Abstract Progenitor B cell acute lymphoblastic leukemia (B-ALL) remains the most common form of childhood cancer and has a poor survival in adult patients. Therefore, efforts to identify further driver mutations in B-ALL are critical. Previously, we identified a truncated form of SOS1 that cooperated with constitutively active STAT5b to induce leukemia. Expression of truncated Sos1 transcript correlated inversely with overall survival. Using a new model of B-ALL characterized by heterozygous expression of Pax5 and Ebf1, we identified increased expression of a truncated form of Sos1 transcript in RNA-Seq analyses. Using western blot analyses, we confirmed the over-expression of smaller SOS1 protein. To identify the truncated Sos1 starting site, we performed 5′ RACE and found a small region of a Riken gene fused to Sos1 at the junction of exon 8 and 9. Further, there is an almost 3 kb truncation of the 3′ untranslated region of Sos1. Next, we used a 10X Genomics approach to identify gene arrangements that showed clear evidence of a linkage between exon 9 of Sos1 and 3′ region of Map4k3. WGS on three independent leukemia samples identified an inversion event between Sos1 and a region downstream of Cdkl4, the location of the RIKEN we identified earlier. These results provide evidence that the truncated Sos1 arises from a micro-inversion event. SOS1 is known to play a critical role in the RAS-ERK signaling pathway and is important in PreBCR signaling. We examined both pERK and pp38. Surprisingly, we found reduced levels of pERK correlated with increased pSTAT5b. Thus, novel chromosomal rearrangements generate a truncated form of SOS1 that plays an important role in transformation of progenitor B cells in B-ALL.
Theoretical Analysis of Harmonics in PWM Output Waveform of Multi-Level Inverters (2013)

Multi-level inverters have very attractive features such as lower harmonics in the output, lower EMI, and reduction of the required voltage rating of power semiconductor devices. Among them, lower harmonics in the output can reduce the volume of the output harmonic filter and additional losses caused by the harmonics. Therefore, multi-level inverters are expected to realize higher power density and higher efficiency. In this paper, as a basis of the quantitative investigation of these features, the harmonics in the PWM output voltage of multi-level inverters are analyzed theoretically. As an application of the theoretical results, the usefulness of the theoretical results is verified by the prediction of the harmonic contents of the load current.
From Neurons to Brain: Adaptive Self-Wiring of Neurons (1998)

During embryonic morpho-genesis, a collection of individual neurons turns into a functioning network with unique capabilities. Only recently has this most staggering example of emergent process in the natural world, began to be studied. Here we propose a navigational strategy for neurites growth cones, based on sophisticated chemical signaling. We further propose that the embryonic environment (the neurons and the glia cells) acts as an excitable media in which concentric and spiral chemical waves are formed. Together with the navigation strategy, the chemical waves provide a mechanism for communication, regulation, and control required for the adaptive self-wiring of neurons.
Microwave enhanced silica encapsulation of magnetic nanoparticles (2012)

The surface modification of various nanoparticles with silica has been exploited to increase their utility for bioapplications. However, silica encapsulation through conventional methods requires long reaction times (hours to days). Herein, we demonstrated that uniform and spherical silica encapsulation of magnetic nanoparticles can be achieved within 10 min via microwave irradiation after phase transferring monodisperse magnetic nanoparticles from organic to water phase. In addition, we showed that silica shell addition through microwave synthesis is more effective than conventional heating methods, such as a hot plate. The approach that we propose may be useful in preparing multifunctional nano-probes, particularly for radiolabeling, which requires fast preparation times.
Nascent rotational and vibrational product state distribution in the charge transfer reaction of N++CO→CO++N at near thermal energy (1986)

An improved ion beam apparatus is used to measure the nascent product state distribution in the charge transfer reaction N++CO→CO++N under single-collision conditions at 0.16 eV energy. At this energy, the major vibrational channel in the CO+ products is v=1, in contrast to the predominant formation of v=0 at thermal energy. The relative vibrational distribution for the N++CO reaction is (0.40±0.07)v=0 : (0.57±0.04)v=1 : (0.03±0.01)v=2. In the v=0 channel, the rotational distribution under single-collision conditions can be characterized by a Boltzmann distribution with a temperature of T=410±40 K. In the v=1 channel the rotational distribution is highly excited and non-Boltzmann. The lower rotational states approximate a very high temperature of 2000 K. For high rotational quantum numbers (K&gt;23), the rotational temperature is about T=810±20 K. The dramatic differences in the rotational distributions are clear evidence that these two vibrational channels are formed by different reaction mechanisms, most likely a direct reaction for v=0, and an intimate collision for v=1.
Visual‐search observers for assessing tomographic x‐ray image quality (2016)

The computationally efficient training requirements for the VS observer are suitable for high-resolution imaging, indicating that the observer framework has the potential to overcome important task limitations of current model observers for x-ray applications.
MAGSCREW TOTAL ARTIFICIAL HEART SYSTEM (2004)

Development of the MagScrew Total Artificial Heart (TAH) focuses on pump size reduction, system integration, and component reliability. The MagScrew actuator serves as the pump drive mechanism and uses helical arrays of permanent magnets to transmit force without the wear associated with mechanical devices and with essentially zero loss. Sensor input to the electronic controller maintains an appropriate motor speed such that the actuator does not contact the left pusher plate during filling, thus allowing the left pumping chamber to fill passively in response to atrial pressure. Motor speed is minimized, consistent with matching the rate of venous return, to conserve energy. An initial in-vivo study investigated pump performance with a tethered actuator controlled by a non-implantable bench replica of the implantable controller. The achieved left and right flows of 9 I/min on average were adequate for the animal model (animal weight at implant: 99 kg, at POD 30: 11S kg). Atrial balance was well maintained throughout the experiment with left and right atrial pressures of 12 and 7 mm Hg, respectively. The complete TAH system consists of the blood pump unit, implantable controller, implantable battery, compliance chamber, refill port, Transcutaneous Energy Transmission System (TETS), and external battery. Both battery packs, TETS, and implantable controller are under test in preparation for full system implants. Initial results indicate an energy supply from the internal battery of 1 hr 20 min and 3 hr 30 min from the external battery pack under normal load conditions (mean Aop = 100 mm Hg, mean PAP = 20 mm Hg).
Investigation of growth kinetics and morphology of sodium fluorosilicate ice‐analogue crystals in solutions and gels (2007)

Abstract The effect of growth method (solution or gel growth) and growth conditions on the morphology of ice analogue crystals (sodium fluorosilicate) has been studied. Many habits typical for atmospheric ice crystals (hexagonal columns, plates, different types of stars or dendrites) were obtained during experiments. The dependence of growth rate of basal and prism faces of columnar crystals on supersaturation was measured for crystals growing by evaporation of solvent. The experiments establish evaporation rate and growth rate ranges at which appearance of certain types of crystals is most probable. The experiments have also shown that good quality sodium fluorosilicate crystals can be obtained in TMS gel. These crystals were significantly bigger than those obtained in solution. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Coherent pulsed injection seeding of two gain-switched semiconductor lasers (1991)

High-power, narrow-spectrum, short pulses at a wavelength near 830 nm are needed for optical logic applications. The authors report the generation of two coherent trains of pulses by pulsed injection seeding of two gain-switched semiconductor lasers with one mode-locked master oscillator. The available power was doubled and both lasers emit in nearly identical spectral lines. Short pulses (30-50 ps) are generated at a repetition rate of 1.9 GHz. The spectrum is reduced to a single mode cluster and shows a 1.7 AA wide chirp suitable for pulse compression. The peak power is 0.1 W for each pulse train. The capability of this technique for coherent power combining is demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Selected Energy Epitaxial Deposition and Low Energy Electron Microscopy of AlN, GaN, and SiC Thin Films (1997)

Abstract : Epitaxial growth GaN films at reasonable rates and at grazing incidence and using conditions similar to those employed for growth in a low energy electron microscope (LEEM) have been achieved. Preliminary phtoluminescence studies showed near band edge luminescence accompanied by yellow luminescence at -2.2eV. In situ experiments in the LEEM at ASU to produce a clean GaN substrate surface for homoepitaxy were performed. Heating the substrate to 880 deg C produced a (lx1) structure with meandering steps on the surface. Cleaning the substrates using a N-atom flux produced different atomic structures depending on the N-atom flux and the substrate temperature. Low N-atom flux gave rise to a structure with clear steps while a higher N-atom flux produced a (3x3) surface with vanishing steps. Growth of GaN on the (3x3) surface produced faceted layers. Additional in situ cleaning research at NCSU of MOCVD- grown GaN/AlN/611-SiC substrates using NH3-seeded supersonic molecular beams was investigated. Surface carbon and oxygen concentrations of-1%, as evidenced by XPS, were achieved by heating at 7300C under a hyperthermal NH3 flux. Oxygen was removed primarily by thermal desorption. In contrast, carbon removal required heating under an NH flux Ex situ AFM reveals a smooth surface with parallel steps after NH3 beam cleaning. 3 Homoepitaxial growth of smooth, highly textured GaN films was accomplished at 7000C by employing a hyperthermal NH3 beam (0.61 eV) and an effusive Ga source.
ChemInform Abstract: Acceleration of Photoinduced Electron Transfer in Porphyrin‐Linked C<sub>70</sub>. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Head Waves in Asian Marginal Seas (2007)

Abstract : The long-term goal is to develop a robust means to utilize readily-obtained precursor (or head-wave-like) arrival measurements for purposes of geoacoustic inversion. These arrivals are important features of shallow water propagation that are exhibited at relatively short ranges ( 1 km). They are more directly linked with seabed properties, in contrast to long-range, trapped modal arrivals. The objective this year was to analyze, model, and invert precursor arrivals measured from the Yellow Sea as part of the August 1996 joint U.S.-China Yellow Sea Experiment [1] using new methods derived the previous year of this grant [2].
Approaches to improving corpus quality for statistical machine translation (2010)

The performance of a statistical machine translation (SMT) system heavily depends on the quantity and quality of the bilingual language resource. However, the pervious work mainly focuses on the quantity and tries to collect more bilingual data. In this paper, we aim to optimize the bilingual corpus to improve the performance of the translation system. We propose methods to process the bilingual language data by filtering noise and selecting more informative sentences from the training corpus and the development corpus. The experimental results show that we can obtain a competitive performance using less data compared with using all available data.
Influence of Geometric Design Parameters Onto Vibratory Response and HCF Safety for Turbine Blades With Friction Damper (2018)

Among the major concerns for high aspect-ratio turbine blades are forced and self-excited (flutter) vibrations which can cause failure by high-cycle fatigue. The introduction of friction damping in turbine blades, such as by coupling of adjacent blades via under platform dampers, can lead to a significant reduction of resonance amplitudes at critical operational conditions. In this paper, the influence of basic geometric blade design parameters onto the damped system response will be investigated to link design parameters with functional parameters like damper normal load, frequently used in nonlinear dynamic analysis. The shape of a simplified large aspect-ratio turbine blade is parameterized along with the under platform damper configuration. The airfoil is explicitly included into the parameterization in order to account for changes in blade mode shapes. For evaluation of the damped system response under a typical excitation, a reduced order model for non-linear friction damping is included into an automated 3D FEA tool-chain. Based on a design of experiments approach, the design space will be sampled and a surrogate model is trained on the received dataset. Subsequently, the mean and interaction effects of the true geometric blade design parameters onto the resonance amplitude and safety against high-cycle fatigue will be outlined for a critical first bending type vibrational motion. Design parameters were mainly found to influence the resonance amplitude by their effect onto the tip-to-platform deflection ratio. The HCF safety was affected by those design parameters with large sensitivity onto static and resonant vibratory stress levels. Applying an evolutionary optimization algorithm, it is shown that the optimum blade design with respect to minimum vibratory response at a particular node can differ significantly from a blade designed toward maximum HCF safety.
THERMAL NECROSIS AFTER TIBIAL REAMING FOR INTRAMEDULLARY NAIL FIXATION (1996)

We present three young men who sustained closed diaphyseal fracture of the tibia and later developed severe osteocutaneous necrosis induced by heat during intramedullary reaming. They all had a narrow medullary cavity and in all a tourniquet had been used. Each developed a pretibial cutaneous blister soon after operation. In the following month severe osteomyelitis ensued, requiring segmental resection and osteocutaneous reconstruction.
Newly Developed Decontamination Technology Based on Gaseous Reactions Converting to Carbonyl and Fluoric Compounds (1998)

A new gas-phase decontamination technology is developed based on gaseous reactions utilizing the volatile properties of the carbonyl and fluoric compounds of radioactive transition elements and actinides (corrosion products, fission products, and transuranium) on a material’s surface. The feasibility of this new technology is determined by removing nonradioactive (Co, Cr, Ni, Re, Mo, Mn, Ru, and Zn) and radioactive (60Co, 63Ni, and 103Ru) nuclide transition elements as gaseous forms under high CO pressure (50 to 200 atm) and high temperature (~350°C). Experiments involving U and using fluoric gases are also performed. For radioactive nuclides existing in an oxide layer of stainless steel, pretreatment with supercritical CO2 + I2 + H2O is used to remove the oxide layer completely, and by the subsequent gaseous reaction, 95 to 99% of 60Co is removed from the layer by CO gas treatment at a pressure of 200 atm. The plasma treatment using fluorine gas results in U being removed with high efficiency (~60%) after only 5 min, even at a reduced pressure of 1 Torr and at room temperature. When the carbonyl and fluoric species generated from a nontoxic gas mixture (1 Torr) of CF4 and O2 is used, U and 60Co are removed simultaneously with high removal efficiencies of 80 and 100% for 60Co and U, respectively. The data provide evidence that chemically reactive plasma treatment is available as a gas-phase decontamination method that can be conducted using nontoxic gases under safe and mild conditions such as reduced pressure, shorter time periods, and ambient temperature. Finally, a fluoric chemical reaction can be used to remove solid U deposits by converting them to gaseous U compounds at room temperature and without using plasma treatment. The pressure of ClF3 gradually affects the higher removal efficiency of U, and the removal efficiency is >90% under the conditions of 30 min and >100 Torr. The results verify that chemical reactions involving carbonylation and fluorination reactions can be utilized for gas-phase decontamination, and the potential for this new idea for decontamination is affirmed.If gas-phase decontamination technology is further developed, it will be not only convenient but also economically advantageous because decontaminating and treating the large volume of nuclear wastes - especially nonincinerable radioactive wastes - are currently very difficult.
Synthesis of functionalized poly(dithienylpyrrole) derivatives and their application in amperometric biosensors (1994)

Biosensors require a method of fixing the sensor components to the transducer surface. For amperometric enzyme electrodes, this means that functionahzed electrode surfaces have to be developed in order to covalently bond enzymes to the electrode surface. The synthesis and electrochemical polymerization of new dithienyl‐pyrrole derivatives are described and the biosensor characteristics of the resulting electrodes are demonstrated using immobilized glucose oxidase as a model enzyme.
Antidepressant agents. 1. Chemistry and pharmacology of amino-substituted spiro[5H-dibenzo[a,d]cycloheptene-5,1'-cycloalkanes] (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntidepressant agents. 1. Chemistry and pharmacology of amino-substituted spiro[5H-dibenzo[a,d]cycloheptene-5,1'-cycloalkanes]B. Carnmalm, E. Jacupovic, L. Johansson, T. De Paulis, S. Ramsby, N. E. Stjernstrom, A. L. Renyi, S. B. Ross, and S. O. OgrenCite this: J. Med. Chem. 1974, 17, 1, 65–72Publication Date (Print):January 1, 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://doi.org/10.1021/jm00247a014RIGHTS & PERMISSIONSArticle Views160Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (970 KB) Get e-Alertsclose Get e-Alerts
Asymmetrical <i>N</i><sup>4</sup>,<i>N</i><sup>9</sup>-Diacyl Spermines: SAR Studies of Nonviral Lipopolyamine Vectors for Efficient siRNA Delivery with Silencing of EGFP Reporter Gene (2012)

Our aim is to study the effects of varying the two acyl moieties in synthesized N(4),N(9)-diacyl spermines on siRNA formulations and their delivery efficiency in cell lines. Six novel asymmetrical lipopolyamines, [N(4)-cholesteryloxy-3-carbonyl-N(9)-oleoyl-, N(4)-decanoyl-N(9)-oleoyl-, N(4)-decanoyl-N(9)-stearoyl-, N(4)-lithocholoyl-N(9)-oleoyl-, N(4)-myristoleoyl-N(9)-myristoyl-, and N(4)-oleoyl-N(9)-stearoyl]-1,12-diamino-4,9-diazadodecane, were assessed for their abilities to bind to siRNA, studied using a RiboGreen intercalation assay, and to form nanoparticles. Their siRNA delivery efficiencies were quantified in FEK4 primary skin cells and in an immortalized cancer cell line (HtTA) using a fluorescein-tagged siRNA, and compared with formulations of N(4),N(9)-dioleoyl-1,12-diamino-4,9-diazadodecane and of a leading transfecting agent, TransIT-TKO. Transfection was measured in terms of siRNA delivery and silencing of EGFP reporter gene in HeLa cells. By incorporating two different acyl moieties, changing their length and oxidation level in a controlled manner, we show efficient fluorescein-tagged siRNA formulation, delivery, and knock-down of EGFP reporter gene. N(4)-Oleoyl-N(9)-stearoyl spermine and N(4)-myristoleoyl-N(9)-myristoyl spermine are effective siRNA delivery vectors typically resulting in 89% cell delivery and gene silencing to 34% in the presence of serum, comparable with the results obtained with TransIT-TKO; adding a second lipid chain is better than incorporating a steroid moiety.
Health leadership for the 21st century – a new, holistic, co-productive endeavour (2012)

Writing as NHS consultants, we put forward here a health leadership model recently published in the Journal of the Royal Society of Medicine (Nicol and Sang, 2010). It encompasses a clinical and a citizen/user perspective and is premised on the belief that if the NHS is to survive, health leadership must now be a co-productive endeavour between health workers, like ourselves, and patients, working within and beyond traditional NHS boundaries. The article links the themes of sustainability – argued so convincingly in the Wanless report (Wanless, 2002); quality – the heart of Lord Darzi’s report (Department of Health, 2008); and co-creative learning and development. It proposes a leadership model that offers an alternative to current public service models (Sang, 2009). The authors believe that the NHS must always, as a minimum, provide safe maternity services; robust and timely emergency services; provide care to those with long-term conditions, looking to enable quality of life, not just quantity of life; and provide for a dignified end to life. However, it is clear that we cannot afford to provide for every possible eventuality and keep the NHS funded as it is. Patients and the wider public need to be engaged with clinicians in an open and frank debate about resource utilisation in a cash-limited NHS. Together, we must accept that tough and uncomfortable decisions are required and be willing to accept joint responsibility for these decisions, even when counter to potential vested interests. A wider view is required to ensure a broad continuous improvement in healthcare, based on reducing inequality and enabling a high-quality experience for all.
Endonasal endoscopic transsphenoidal excision of tuberculum sellae meningiomas: a systematic review. (2016)

The endonasal endoscopic transsphenoidal excision of TSMs is a feasible, safe and effective surgical option with a low morbidity and mortality. The use of this approach has evolved in the last 10 years and in some centers has replaced the transcranial route for selected cases. Given the limited availability and heterogeneity of comparative observational studies, a direct comparison with transcranial approaches was not performed for the purpose of this review analysis. Likewise, from an epidemiological and statistical perspective a meta-analysis was deemed inappropriate.