gebhart/patrepeval huggingface dataset:
Autoradiographic detection of kinin receptors in the human medulla of control, hypertensive, and diabetic donors (2002)

Kinins have been elected to the status of central neuromediators. Their effects are mediated through the activation of two G-protein-coupled receptors, denoted B, and B2. Functional and binding studies suggested that B1 and B2 receptors are upregulated in the medulla and spinal cord of hypertensive and diabetic rats. The aim of this study was to localize and quantify kinin receptors in post-mortem human medulla obtained from normotensive, hypertensive, and diabetic subjects, using in vitro receptor autoradiography with the radioligands [125I]HPP-HOE140 (B2 receptor) and [125I]HPP[des-Arg10]-HOE140 (B1 receptor). Data showed specific binding sites for B2 receptor (0.4-1.5 fmol/mg tissue) in 11 medullary nuclei from 4 control specimens (paratrigeminal > ambiguus > cuneate, gelatinous layer of the caudal spinal trigeminal nucleus > caudal and interpolar spinal trigeminal, external cuneate, solitary tract > hypoglossal > gracile > inferior olivary nuclei). Increased density of B2 receptor binding sites was observed in seven medullary nuclei of four hypertensive specimens (paratrigeminal > external cuneate > interpolar and caudal spinal trigeminal, gracile, inferior olivary > hypoglossal nuclei). B2 receptor binding sites were seemingly increased in the same medullary nuclei of two diabetic specimens. Specific binding sites for B1 receptor (1.05 and 1.36 fmol/mg tissue) were seen only in the inferior olivary nucleus in two out of the ten studied specimens. The present results support a putative role for kinins in the regulation of autonomic, nociceptive, and motor functions at the level of the human medulla. Evidence is also provided that B2 receptors are upregulated in medullary cardiovascular centers of subjects afflicted of cardiovascular diseases.
High-aperture raster holography for particle imaging (1994)

A novel approach to in-line particle holography is described, and its superiority is experimentally demonstrated. During recording, a raster diffuser is used to increase the effective angular aperture of particle scattering, and a raster screen is placed in front of hologram to mask the unscattered diffuse light. In reconstruction, a new type of spatial filter passes only the spherical waves from the interrogation region, effectively blocking the reconstruction beam, separating the real and virtual images, and suppressing the strong forward scattering. This new scheme provides particle images with higher contrast, reduced speckle noise, and a smaller depth of focus than conventional in-line holography.
A CFD analysis for the performance assessment of a novel design of plates-in-tank latent storage unit for freezing applications. (2019)

In this paper, the charging and discharging processes of a recently developed cold thermal energy storage (CTES) unit integrated into a poultry processing plant is investigated. A mathematical model of the CTES was created based on the two-dimensional transient Navier-Stokes equations using the ANSYS Fluent commercial software package. Thermal storage is commonly designed either for full storage (to meet the entire needs during peak hours) or for partial storage (to meet a fraction of the needs when there is a time shift between the energy supply and demand). In this study, the storage unit is designed to operate in a full storage operational mode integrated in the R744 circuit of a R717/R744 cascade refrigeration system. The CTES unit consists of a stack of heat exchanger (HEX) plates immersed in a steel tank filled with a phase change material (PCM). The selection of the appropriate PCM is based on the operational temperature range required in the system. Water is chosen as the PCM for this study. It is characterised by a high energy storage density and well-defined thermal properties. The HEX plates are called pillow plates (PP-HEX), and consists of two spot-welded and inflated steel plates that allows the CO2 to circulate in a specific pattern and enhance the heat transfer. The CO2 circulates within the plates to freeze and melt the PCM during the charging and discharging processes, respectively. The pressure-based model was selected to model the phase change based on the enthalpy-porosity formulation. This study aims to evaluate the relevance of detailed modelling of the PP-HEX structure compared to flat walls for the melting/solidification process. Results show that the flat wall model have comparable melting/solidification time and heat transfer rate to the PP-HEX geometry.
A spatially resolved photodissociation region in the planetary nebula NGC 7027 (1993)

The high spatial resolution, narrowband, IR line images and CO interferometer data presented for NGC 7027 trace emissions from the central H II region, the intermediate dissociative region, and the molecular circumstellar envelope. Attention is given to the remarkable change in morphology observed in the H2 emission and the dust feature. It is reasoned that the exterior H2 loops of the galaxy are due to molecular gas that is heated by the far-UV emission escaping from the H II region and delineates a photodissociation front.
Increased collagen deposition in an uncomplicated surgical wound compared to a minimal subcutaneous test wound (2001)

Little information is currently available concerning the relationship between results obtained in humans from surgical test wounds and results from wound models. Therefore, to evaluate human wound healing parameters, tubings of expanded polytetrafluoroethylene were implanted in a subcutaneous test wound in the arm of 47 volunteers and 20 patients undergoing hernia repair. The surgical patients also had implants left in the surgical wound cavity. After 10 days the deposition of collagen in the tubings as expressed by hydroxyproline content was 30% higher in the surgical wound than in the test wound, p < 0.05. The amount of collagen deposited in the tubing within the surgical wound did not correlate with measurements in the test wound, whereas a significant correlation of proline levels was found between the two sites, p < 0.05. Deposition of proline and total protein in the model was equivalent. In both wound types age negatively correlated with levels of protein, but not collagen. The variability of the results was 40% lower in the subcutaneous test wound than in the surgical wound. There was no significant difference in hydroxyproline deposition between the volunteers and the patients undergoing hernia repair. In patients undergoing minor surgery without signs of compromised healing the expanded polytetrafluoroethylene test wound in the arm reflects the deposition of non-collagenous protein, but not collagen, within the surgical wound.
Effective angiostatic treatment in a murine metastatic and orthotopic hepatoma model† (2005)

Vascular endothelial growth factor (VEGF) activity is correlated with a progressive tumor disease in patients with hepatocellular carcinoma (HCC). In spite of the well-recognized role of VEGF in HCC, there are few data available regarding therapeutic strategies to block VEGF activity. Therefore, we employed a recombinant adenoviral vector encoding a soluble dominant negative fragment of VEGF receptor 2 (Flk-1), AdsFlk-1, to control pre-established murine orthotopic and metastatic hepatomas. Vector function was confirmed via reverse-transcriptase polymerase chain reaction and ELISA, and angiostatic effects were analyzed in vitro and in vivo. Antitumoral effects of systemic AdsFlk-1 application were studied in a subcutaneous and orthotopic Hepa129 HCC model. Cell supernatant containing the truncated form of Flk-1 had no direct effect on cell proliferation of Hepa129 cells in vitro but reduced endothelial tube formation on matrigel matrix by approximately 80% in vitro. Endothelial-like cell infiltration into matrigel plugs in vivo was also decreased by 80%. Systemic treatment of tumor-bearing mice inhibited tumor growth by 84% compared with the corresponding control group within 16 days after vector application. Likewise, the survival rate was significantly improved in the AdsFlk-1 group compared with control. Orthotopic tumor growth was reduced by 82%, and development of malignant ascites was also retarded. In conclusion, systemic adenoviral-mediated gene transfer of an Flk-1 fragment significantly inhibited tumor growth in orthotopic and metastatic murine HCC. The data support the value of VEGF blockade as an effective target for HCC treatment.
Binocular Stereoptic Acuity and Spatial Localization As Criteria for the Evaluation of Contact Lenses (1951)

Abstract : To provide an exemplary experimental evaluation of two contact lenses with measures of binocular stereoptic acuity and of spatial localization obtained with a stereoptometer as criteria. To provide a preliminary test of the hypotheses that changes in binocular stereoptic acuity and changes in spatial localization take place when contact lenses are worn.
Balling processes during selective laser treatment of powders (2004)

Abstract The particularities of the selective laser processing of single‐component metal powder layers were investigated, especially the occurrence of the balling‐processes under different processing conditions. During laser processing, sintered, semi‐sintered/semi‐melted or completely melted cakes can be formed. Size and shape of the laser processed parts can change depending on the energy and time parameters of the laser irradiation and on the properties of initial powder layers.
BP neural network-based web service selection algorithm in the smart distribution grid (2014)

A good web selection algorithm can provide the most suitable service for users. However, known for its slow convergence rate and proneness of oscillation in its learning process, the traditional error back propagation neural network algorithm cannot be applied in the service selection scenarios of actual smart distribution grid. In order to meet the requirements of telecommunication technology for smart distribution grid and improve the quality of telecommunication service, this paper proposes an improved error back propagation algorithm, in which the learning factor can be self-adjusted with every iteration. The simulation results show an optimization of the training speed and an oscillation reduction in the learning process with the new algorithm, thus obvious optimizing the web services selection in smart distribution grid.
Chronic secondary hypersensitivity of dorsal horn neurones following inflammation of the knee joint (2007)

Intra-articular injection of Freund's complete adjuvant (FCA) into the rat knee joint produces a swelling of the joint and long lasting hypersensitivity. In this study we have used this model and in vivo electrophysiology to investigate the time course of spinal changes underlying chronic secondary hypersensitivity, by stimulating the ankle joint (an area outside the site of primary hypersensitivity), and have compared the results with behavioural data from the same population of animals at 4-8, 13-17 and 55-59 days following FCA injection. The magnitude of responses and the proportion of dorsal horn neurones receiving inputs from A beta- A delta- and C-fibre afferents were monitored. At all time points, there was a significant increase in the ongoing activity of deep dorsal horn neurones when compared to nai ve rats, correlating well with the behavioural hypersensitivity. Both the magnitude of neuronal responses, and the proportion of neurones responding to electrical or mechanical stimulation in an area of secondary hypersensitivity, were significantly increased 4-8 and 13-17 days following FCA injection. However, while there was still behavioural hypersensitivity at 55-59 days there was a substantial decline in the responses to mechanical stimulation and A-fibre responses to electrical stimulation, although the proportion of neurones responding in the C-fibre latency remained elevated. These results suggest that the behavioural hypersensitivity is due to hyperexcitability at the level of the dorsal horn reflected as an increase of both C-fibre responses and spontaneous activity.
Characterization of nanostructures by reflection electron microscopy (1990)

We use reflection electron microscopy (REM) to analyze ion-etched nanostructures defined in compound semiconductor heterostructures. This nondestructive imaging technique allows us to characterize 10-nm-wide features with high resolution and determine their sidewall morphology on a 1 nm scale. In addition to the inherent high-resolution available from REM, we also obtain diffraction contrast from the heterostructure material, and we can image quantum wells. We routinely use this technique to characterize and accurately measure microfabricated structures with lateral dimensions below 20 nm.
The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for theα-Glycosylation of Primary Hydroxy Groups (2001)

5-Azido sialyl donors with O-acetyl protecting groups are useful α-selective glycosylation reagents, especially for primary hydroxyl groups as acceptors. This is shown with a variety of reactions using 1 as a sialyl donor. It was also possible to synthesize NeuAcα(2→9)NeuAc as a thioglycoside donor for use in subsequent glycosylations.
Normal left ventricular function with total occlusion of right and left main coronary arteries (1980)

This report describes a unique case of normal left ventricular function in a patient with total proximal occlusion of the entire native coronary circulation in addition to an occluded left anterior descending bypass graft. Coronary flow was maintained by a sequential saphenous vein graft to the obtuse marginal and posterior descending arteries, with collateral filling of the left anterior descending vessel. Myocardial function was preserved, presumably because of the relatively gradual process of native coronary occlusion, allowing time for development of adequate collateral perfusion.
Improved linear programming method to generate metameric spectral distributions (1995)

We present an application of linear-programming techniques to generate metameric spectral radiant power distributions. Conditions concerning physical color properties, dominant wavelength, and excitation purity lead us to propose criteria that provide distributions associated with color stimuli with high-excitation purity values of any brightness. An unlimited number of metameric distributions can be obtained from the degrees of freedom introduced by the proposed criteria.
Design and Implementation of Ubiquitous Parking Management System using Sensor Network (2007)

In this paper, a ubiquitous parking management system(UPMS) using sensor network is proposed. Ubiquitous parking management system provides information on free space in the parking lot through PDA or cellular phone connected to wireless LAN. For the implementation of UPMS, we have developed sensor node, sensor application and web server application. The proposed system periodically updates parking space data and monitors in real-time according to the user's request from the personal internet device. Collected parking data are stored onto the database for further analysis. The implemented UPMS system was installed on campus parking lot using 10 sensor nodes and we successfully demonstrated its feasibility by accessing the web server from out of the campus.
Dramatic acceleration of migratory insertion in [MeIr(CO)2I3]? by methanol and by tin(II) iodide (1995)

Carbonylation of [MeIr(CO)2I3]– to [MeCOIr(CO)2I3]– requires temperatures >80 °C in chlorobenzene, but is dramatically accelerated on addition of methanol (×104 at 33 °C) or of the Lewis acid Snl2(× 200 at 93 °C); the acceleration is proposed to arise from activation of an Ir–I bond.
On the measurement of dose in-air for small radiation fields: choice of mini-phantom material (2015)

The purpose of this work was to determine the effect of choice of mini-phantom material on the measurement and calculation of in-air output factors (Sc) in small fields. Monte Carlo simulations in conjunction with a theoretical determination of Sc were used to validate previously reported measurements. Options for alternative mini-phantom materials were compared. A 6 MV beam from a Varian Novalis linear accelerator operating in stereotactic (SRS) mode was modelled. Phase-space data were used to determine the theoretical value of Sc. To validate previously reported Sc measurements the data were used to model the fibre-optic detector and brass mini-phantom. The impact of mini-phantom material was investigated by comparing the energy spectra of electrons entering the detector volume as a function of field size, and comparing the simulated Sc-measurement to the theoretical calculation. In order to determine factors leading to changes in Sc with field size, the origins of particles in the beam as incident on the mini-phantom were determined. Sc values derived from simulated measurements using a brass mini-phantom on a fibre-optic detector agreed with the measured Sc to within 0.7%. For simulation of measurement for all other mini-phantom materials, Sc values agreed with the theoretically calculated values to within 0.6%. The dominant processes responsible for a decrease in Sc with field size is occlusion of the focal and primary collimator contributions, while the secondary scatter, from the flattening filter and cone collimators, has minimal effect. The secondary electron spectrum is affected by the choice of mini-phantom material, but is almost independent of field size. For cone-collimated small fields in the Novalis beam (<30 mm), the decrease in Sc with field size is primarily due to collimation of the focal radiation beam and scatter from the primary collimator. A fibre optic detector with either a brass, gold or lead mini-phantom with at least d(max) equivalent height is suited to measure Sc for small SRS fields. The use of materials with higher electron/physical density can be used to reduce the size of the mini-phantom and reduce spatial averaging.
Multiscale cell mechanics: from soft matter physics to medical applications (2010)

Séminaire
Polystyrene and Lucite Rod Antennas (1953)

First Page
Structural Control of Poly(Methyl Methacrylate)-<i>g</i>-poly(Lactic Acid) Graft Copolymers by Atom Transfer Radical Polymerization (ATRP) (2001)

Atom transfer radical copolymerization of methyl methacrylate (MMA) and (meth)acrylate-terminated poly(lactic acid) (PLA) macromonomers was investigated. The relative reactivity of methacrylate-terminated macromonomer (1/rMMA = 1.75) and acrylate-terminated macromonomer (1/rMMA = 0.61) was close to that of 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate, respectively. The difference in reactivity in ATRP and conventional radical polymerization is discussed in terms of the diffusion control effect. A mixture of methacrylate-terminated macromonomer and acrylate-terminated macromonomer was copolymerized with MMA by ATRP to give a homogeneously branched PMMA-g-PLA graft copolymer with low polydispersity (Mw/Mn = 1.15).
Molecular mechanisms involved in T cell activation. II. The phosphatidylinositol signal-transducing mechanism mediates antigen-induced lymphokine production but not interleukin 2-induced proliferation in cloned cytotoxic T lymphocytes. (1987)

The phospholipid metabolism of cloned murine cytotoxic T lymphocytes (CTL) was examined under conditions in which the induction of proliferation by interleukin 2 (IL 2) and the stimulated production of lymphokine (macrophage-activating factor (MAF] by concanavalin A (Con A) and specific antigen occurred independently of each other. Activation of the CTL by either of the latter two stimuli resulted in changes in the metabolism of phosphatidylinositol (PI) that were early (less than 2.5 min), specific, and prolonged (6 to 8 hr). These changes were primarily characterized by an increase in phosphatidic acid (PA) and PI, with a decrease in phosphatidylinositol-4,5-bisphosphate. The duration of these phospholipid responses, particularly PA and PI, approximated the minimum time of CTL-stimulus interaction required to produce maximal titers of MAF. No changes were observed in other major classes of phospholipids during 8 hr of continuous stimulation. Stimulation with an irrelevant antigen had no effect on CTL phospholipid metabolism. In contrast to specific antigen or Con A, the T cell growth factor IL 2 failed to elicit specific and early biosynthetic responses from PA and PI. Instead, there were nonspecific biosynthetic responses from all major phospholipid classes (including phosphatidylcholine and phosphatidylethanolamine, as well as PA and PI) which occurred between 1 and 6 hr after IL 2 stimulation. Both 1,2-diacylglycerol (DAG) and inositol phosphates (IP), the hydrolytic products of PI turnover, were produced in response to MAF-inducing stimuli, but neither were detected in response to the proliferative stimulus IL 2. Together, these results indicate that the hydrolysis of PI and the concomitant production of the putative second messengers DAG and IP are involved in signaling the production of lymphokines (MAF) by CTL. On the other hand, the failure of IL 2 to elicit a full-spectrum PI response suggests that signals mediating CTL proliferation may utilize an alternate and still undefined pathway.
Group IV Metal Dimethylamido Complexes of the Chiral Cyclopentadienyl‐type Ligand (Cp<sup>C</sup>)<sup>–1</sup> (2020)

Abstract . Trisdimethylamido complexes of the Group IV elements titanium, zirconium and hafnium bearing the chiral Cp‐type ligand (Cp C ) –1 were synthesized and characterized by means of NMR spectroscopy, elemental analysis and single crystal X‐rax diffraction.
Corona destruction: An innovative control technology for VOCS and air toxics. Rept. for Oct 90-Mar 91 (1992)

The research effort in corona destruction of volatile organic compounds (VOCs) and air toxics has shown significant promise for providing a valuable contribution to critical EPA and national goals of attaining the ozone standard in more than 100 non-attainment areas nationwide and reducing the health effects associated with exposures to hazardous air pollutants. The corona destruction technology could be especially useful in future years in helping industry meet the residual risk requirements of the Clean Air Act of 1990. Since 1988, EPA's Air and Energy Engineering Research Laboratory has conducted research in the area of corona destruction of VOCs and air toxics. The emerging concern for excessive concentrations of ambient ozone, for which many VOCs are precursors, the need to develop technology to control low concentration streams, and the economic advantages of ambient temperature operation provided impetus for the work on high intensity corona reactor devices. The purpose of the work is to develop an industrial scale corona reactor capable of efficiently and cost-effectively destroying VOCs and air toxics at ambient temperature and pressure. The work and results to date leading to the demonstration of the corona destruction process at pilot scale are presented in the paper.
Eco-friendly synthesis of Tellurium nanoparticles and synergic antibacterial coatings in combination with titanium nanocolumns (2019)

Trabajo presentado al European Congress and Exhibition on Advanced Materials and Processes (EUROMAT), celebrado en Estocolmo (Suecia) del 1 al 5 de septiembre de 2019.
Correlation-Based Rectangular Encoding (2009)

In this paper, a technique is presented for improving the compression achieved with any linear decompressor by adding a small nonlinear decoder that exploits bit-wise and pattern-wise correlations present in test vectors. The proposed nonlinear decoder has a regular and compact structure, and allows continuous-flow decompression. It has a very important feature, which is that its design does not depend on the test data. This simplifies the design flow and allows the decoder to be reused when testing multiple cores on a chip. Experimental results show that combining a linear decompressor with the small nonlinear decoder proposed here significantly improves the overall compression.