gebhart/patrepeval huggingface dataset:
A Study of Fluorinated β-Nitrostyrenes as Antimicrobial Agents (2012)

The effect of variously fluorine-substituted β-methyl-β-nitrostyrenes on their antimicrobial activity was investigated. Their efficacy was determined by minimum inhibition concentration (MIC) in cultures of Gram positive and Gram negative bacteria and a fungus. Highest activity against the Gram negative bacterium, E.coli, was achieved with 4-fluorine-aryl substituted β-methyl-β-nitrostyrenes, while most compounds gave excellent results against gram positive bacteria. Importantly, the addition of the β-methyl group profoundly enhanced the antibacterial activity of the compounds tested. The comparative KD values for the most potent compounds against E.coli were much lower than those required for the gram positive and fungus counterparts. This investigation illustrated that fluorine substituted nitropropenylarenes have enhanced antimicrobial activity suitable for antibiotic applications.
Bioluminescence imaging of tumor growth and genetic determinants of response to anti-cancer therapy (2004)

Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text W. S. El-Deiry, "Bioluminescence imaging of tumor growth and genetic determinants of response to anti-cancer therapy," in Frontiers in Optics 2004/Laser Science XXII/Diffractive Optics and Micro-Optics/Optical Fabrication and Testing, OSA Technical Digest Series (Optica Publishing Group, 2004), paper FThK4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Rhodium carbenoid mediated cyclisations. Part 4. Synthetic approaches to oxepanes related to zoapatanol (1989)

Synthetic approaches to the oxepane diterpene zoapatanol are described, in which the key step is the formation of the 7-membered cyclic ether by a rhodium carbenoid cyclisation. The model oxepane (15) was synthesised from (E)-geraniol by selective epoxidation of the allylic alcohol, followed by conversion into the corresponding epoxy iodide (9). Reaction of the iodide with the anion of ethyl acetate gave, after opening of the epoxide, diazo-transfer and acetylation, the substrate (14) for cyclisation. Treatment of (14) with rhodium(II) acetate resulted in cyclisation to the required oxepane (15) in good yield (Scheme 3). The approaches to the functionalised side chain of zoapatanol centred on the allylic alcohols (25), prepared by allylic oxidation of geraniol and functional group transformation. After asymmetric epoxidation, these substrates were converted into the diazo alcohols (30) using a similar sequence to above (Scheme 5). Finally, cyclisation using rhodium(II) acetate gave the unstable optically active oxepanes (31), which were characterised by conversion into the silyl enol ethers (32).
Antinociceptive effects of des-octapeptide-insulin connected with enkephalins (2009)

Three insulin analogues with modifications of the B-chain were synthesized by trypsin-catalyzed coupling of des-octapeptide (B 23 -B 30 )-insulin (DOI) with Met 5 -enkephalin (Met 5 -enk) or Leu 5 -enkephalin (Leu 5 -enk). The derivatives DOI-Met 5 -enk and DOI-Leu 5 -enk were prepared by a condensation between the amino group of the enkephalins and the carboxyl group of arginine in position B 22 . To test the properties of DOI as a navigating molecule of active opioid peptides, we examined DOI, DOI-Met 5 -enk and DOI-Leu 5 -enk following three types of in vivo nociceptive methods: writhing test in mice, paw-pressure test and hot plate test in rats. The peptides were administered both intracerebroventricularly (icv) and subcutaneously (sc). The ability of the peptides to inhibit the electrically-evoked contraction in guinea-pig ileum and mouse vas deferens was also tested. To prove the opioid nature of the responses we used naloxone (1 mg/kg intraperitoneally). Using paw-pressure and hot-plate test, all compounds exerted well-pronounced antinociceptive effects (DOI < DOI-Met 5 -enk < DOI-Leu 5 -enk), with duration at least 40 min after icv application. The differences in order of potency were established after sc application and the effects of all compounds were developed for 20 min. The results obtained with writhing test in mice showed that all compounds did not influence the visceral pain. In vitro effects were poor and were observed at concentration higher than 20 μM for DOI-Met 5 -enk and higher than 100 nM for DOI-Leu 5 -enk. The present results suggested that the derivatives of DOI: DOI-Met 5 -enk and DOI-Leu 5 -enk achieved prolonged antinociceptive action, while DOI at some extent could be used as a transport molecule across the blood-brain barrier.
Tissue Cultures and Secondary Metabolites of Tissue Cultures and Secondary Metabolites of Tissue Cultures and Secondary Metabolites of Tissue Cultures and Secondary Metabolites of Centaurium scilloides (1998)

Shoot and callus cultures of Centaurium scilloides (Gentianaceae) were established and the secondary metabolites of the cultures were determined. The major constituents of the shoots cultured on phytohormone free 1/2 MS solid medium were bitter secoiridoid glucosides, swertiamarin (SA) and gentiopicrin (GP). The content of SA in the aerial part was much larger (ca. 6% dry weight) than that in the root portion, although GP content was not so much different in both parts. On the contrary, the major constituent in the callus cultured on 1/2 MS solid medium supplemented with 1.0 mg/l 2,4-D and 0.1 mg/l BA was 3, 5, 6, 7, 8-pentamethoxy-1-O-primeverosylxanthone (PX) and the bitter principles (SA and GP) were produced at very low level. In the time course experiment of the callus cultures, PX showed the maximum content at week 8 of the culture, and the content decreased at the end of the culture period. Callus was also derived from the regenerants which were formed directly on the adventitious roots. The constituents of the callus were similar to those detected in the callus derived from the seedlings. The secondary metabolites as well as the morphology of the regenerants were also similar to those of the seedling plantlets in vitro. These observations showed the stability of the characters in the morphology and secondary metabolism of this plant through some tissue culture stages such as subculture, direct regeneration from the root, etc.
The Effects of Thrombin on Adenyl Cyclase Activity and a Membrane Protein from Human Platelets (1972)

Washed human platelets were incubated with 0.1-1.0 U/ml human thrombin and the effects on adenyl cyclase activity and on a platelet membrane protein (designated thrombin-sensitive protein) were studied. Adenyl cyclase activity was decreased 70-90% when intact platelets were incubated with thrombin. The T(1/2) for loss of adenyl cyclase activity was less than 15 sec at 1 U/ml thrombin. There was no decrease of adenyl cyclase activity when sonicated platelets or isolated membranes were incubated with these concentrations of thrombin. Loss of adenyl cyclase activity was relatively specific since the activities of other platelet membrane enzymes were unaffected by thrombin. Prior incubation of platelets with dibutyryl cyclic adenosine monophosphate (AMP), prostaglandin E(1), or theophylline protected adenyl cyclase from inhibition by thrombin. Incubation of intact but not disrupted platelets with thrombin resulted in the release of thrombin-sensitive protein from the platelet membrane. The rapid release of this protein (T(1/2) < 15 sec) at low concentrations of thrombin suggested that removal of thrombin-sensitive protein from the platelet membrane is an integral part of the platelet release reaction. This hypothesis is supported by the parallel effects of thrombin on adenyl cyclase activity and thrombin-sensitive protein release in the presence of dibutyryl cyclic AMP, prostaglandin E(1), and theophylline at varying concentrations of thrombin.
A partitioned redundancy management scheme for an eight-joint revolute manipulator (2000)

A partitioned redundancy management approach is developed for a class of eight-joint manipulators with four-axis intersecting wrists. Segmenting the excess degrees of freedom at the wrist simplifies the inverse kinematics problem substantially and allows different and often competing schemes to be used for controlling the motion of the arm. In the upper arm, the roll angle of the shoulder–elbow–wrist plane is controlled directly. In the wrist, the spare joint is used to minimize the instantaneous joint velocities. In addition, the partitioning scheme substantially reduces the number of singularities that can be encountered by the arm and thus actively avoided. A new four-axis “skew” wrist design is also introduced which doubles the workspace size of the traditional orthogonal design while retaining the ability to avoid singularities. Simulations are used to illustrate the redundancy management approach on the dexterous manipulator for a submersible robotic vehicle. © 2000 John Wiley & Sons, Inc.
Strong inhibition of quantum dot spontaneous emission in photonic wires (2010)

International audience
A randomized, double-blind, placebo-controlled pilot study of IV immune globulins in combination with IV methylprednisolone in the treatment of relapses in patients with MS (2004)

Our study could not show superiority of IVMP-IVIg in the treatment of moderate to severe acute relapses in MS.
Two-dimensional acoustic micromanipulation using a line-focused transducer (2002)

Control of position of particles using acoustic radiation pressure in water was studied in order to develop a non-contact micromanipulation technique. The radiation pressure traps particles suspended in water and forms agglomeration every half wavelength in an ultrasonic standing wave field. This paper describes a method to transport the particles two-dimensionally using a line-focused transducer with multiple electrodes. The transducer was fixed upward in water and a ceramic plate reflector was set at the focal line. When an alumina suspension was poured with a pipette into the sound field, the particles were trapped and agglomerated near the reflector. Changing the frequency alters the wavelength and hence the interval of agglomeration. Therefore the trapped particles were transported along the sound beam axis. When the next electrodes were driven, the standing wave field shifted laterally and the trapped particles moved to the corresponding nodal points. Thus two dimensional transportation was realized by using the line-focused transducer.
[Endotamponade with silicon oil in severe proliferative retinopathy with attached retina]. (1995)

Silicone oil as endotamponade in cases with attached retina is only indicated in a few very selected cases. These are cases with a high risk of intravitreal hemorrhage and a need for quick visual rehabilitation. We examined 23 patients, who had undergone pars plana vitrectomy and silicone oil filling. All patients were diabetics with proliferative retinopathy and recurrent intravitreal hemorrhage. In 14 cases it was the only eye; 11 eyes previously had a vitrectomy. We analyzed these cases for visual acuity, rubeosis, bleeding tendency, reproliferations, cataract development and glaucoma. The follow-up time was 32 months. In 22 of 23 eyes quick visual rehabilitation was achieved, and the patients had at least ambulatory vision within the first week. In one case poor visual acuity was due to exudative maculopathy. No relevant bleeding occurred. In 14 of 16 phacic patients we observed a cataract. Seven patients developed glaucoma, which was due to neovascularization in 5 cases. It was successfully treated in all cases and no visual loss occurred. In 5 cases we observed a peripheral traction retinal detachment, in one case a traction retinal detachment at the posterior pole. In selected cases silicone oil can prevent recurrent intravitreal hemorrhage, allowing rapid visual recovery. Considering the complications, the silicone oil should be removed as soon as possible.
Amortizing Secure Computation with Penalties (2016)

Motivated by the impossibility of achieving fairness in secure computation [Cleve, STOC 1986], recent works study a model of fairness in which an adversarial party that aborts on receiving output is forced to pay a mutually predefined monetary penalty to every other party that did not receive the output. These works show how to design protocols for secure computation with penalties that guarantees that either fairness is guaranteed or that each honest party obtains a monetary penalty from the adversary. Protocols for this task are typically designed in an hybrid model where parties have access to a "claim-or-refund" transaction functionality denote FCR*.
Prognose von Stabilitätsgrenzen beim Fräsen (2009)

Kurzfassung Zur Prognose von Stabilitätsgrenzen von Zerspanprozessen werden Stabilitätskriterien auf die verkoppelten Modelle des Prozess- und Maschinenverhaltens angewandt. Der verwendete Berechnungsalgorithmus sowie die Modellkomplexität haben dabei Einfluss auf die Prognosegenauigkeit und den erforderlichen Rechenzeitaufwand. Der Beitrag zeigt den Einfluss des Werkzeug-Drallwinkels auf die Stabilitätsgrenze für ein Maschinenverhalten mit mehreren relevanten Eigenformen. Anhand eines durch Simulationen im Zeitbereich untersuchten Referenzprozesses wird dabei dargestellt, unter welchen Randbedingungen Modellvereinfachungen zulässig sind, die eine rechenzeiteffiziente Ratterkartenberechnung ermöglichen.
pVT Measurements and Related Studies on the Binary System nC<sub>16</sub>H<sub>34</sub> -nC<sub>17</sub>H<sub>36</sub> and on nC<sub>18</sub>H<sub>38</sub> at High Pressures (2001)

Abstract The phase diagram of the binary system nC 16 H 34 -nC 17 H 36 has been established at ambient pressure using DSC and crystallographic measurements. At low temperatures below the rotator phase RI there exist two crystal forms Op (about x(C 17 ) = 0.25) and Mdci (about x(C 17 ) = 0.67) which are different from the crystal structures of the pure compounds (Tp for C 16 and Oi for C 17 ). Furthermore two compositions: (a) C 16 /C 17 = 3:1 and (b) = 1:2, which correspond to the coexistence range of Op and Mdci, were chosen for high pressure DTA and pVT measurements, yielding the following findings: The specific volume of the rotator phase of C 17 is distinctly lower than those of the binary systems at the same state point. Assuming the existence of a metastable rotator phase for C 16 , an excess volume of Δ V E /V ≈ 0.01 can be estimated. Due to the very enlarged coexistence range of RI, the mixtures reach their lower transition point at considerably lower temperatures (in isobaric measurements) or higher pressures (in isothermal measurements), where the specific volume is lower than that of C 17 at its transition point. Furthermore, the volume and enthalpy changes of the Φ ord -RI transition is distinctly smaller for the binary systems than for pure C 17 . Thus the specific volumes of the phases Op and Mdci are appreciably larger than ν(spec.) of C 17 . Op and Mdci have practically the same specific volume in accordance with the crystallographic results. Enthalpy values are obtained with the aid of the Clausius-Clapeyron equation which agree well with enthalpies derived from the DSC measurements. Furthermore, pVT data have been established for the liquid and solid phases of nC 18 H 38 in the neighbourhood of the melting curve, allowing to determine volume and enthalpy changes of melting as a function of pressure.
2006 Toyota Highlander-6395 Hyrid Electric Vehicle Battery Test Results (2010)

The U.S. Department of Energy's Advanced Vehicle Testing Activity conducts several different types of tests on hybrid electric vehicles, including testing hybrid electric vehicles batteries when both the vehicles and batteries are new, and at the conclusion of 160,000 miles of accelerated testing. This report documents the battery testing performed and battery testing results for the 2007 Toyota Highlander hybrid electric vehicle (Vin Number JTEDW21A160006395). Testing was performed by the Electric Transportation Engineering Corporation. The Advanced Vehicle Testing Activity is part of the U.S. Department of Energy's Vehicle Technologies Program. The Idaho National Laboratory and the Electric Transportation Engineering Corporation conduct Advanced Vehicle Testing Activity for the U.S. Department of Energy.
Preparation of Biologically Active Messenger RNA from Larvae of the Common Cattle Grub (Diptera: Oestridae) (1990)

Messenger RNA was prepared from first instars of the common cattle grub, Hypoderma lineatum (Villers). Larvae were excised from esophagi of cattle and frozen in liquid nitrogen. Messenger RNA was extracted by grinding the frozen tissue with hot phenol, partitioning the nucleic acids into an aqueous phase, precipitation with ethanol, and chromatography on oligo(dT)-cellulose. Poly(A)-RNA extracted by this method retained biological activity as demonstrated by in vitro translation using rabbit reticulocyte lysate and [35S]-Met. H. lineatum proteins produced by in vitro translation were analyzed by dodecylsulfate-polyacrylamide gel electrophoresis and autoradiography. Immunoaffinity isolation of specific H. lineatum proteins demonstrated translational fidelity of the mRNA.
Development of a Rotating Human Research Facility (1994)

A unique facility has been developed at the NASA Ames Research Center to provide scientists with unusual research opportunities at greater than Earth's gravity. In addition to its use for basic research, this facility will help provide answers to many of the questions posed by proponents of rotating human space vehicles. This paper describes the design and planned use of this facility, the Spaceflight Environmental Simulator. Using an existing 52-foot diameter cylindrical rotating platform design centrifuge, the revised facility design includes the provision of two human habitats for long duration studies of the effects of hypergravity. Up to four humans (per habitat) will be able to live at up to 2 G for as long as one month without stopping the centrifuge. Each habitat, constructed of lightweight honeycomb sandwich panels, is nominally 9 ft high x 11 ft wide x 25 1/2 ft long. A radial positioning system provides for positioning each habitat at a distance of 15 to 21 feet from the centrifuge's axis of rotation to the midpoint of the habitat's interior floor. As centrifugal acceleration changes with rotation rate, a habitat floor-mounted accelerometer signal provides automatic servo controlled adjustment of each habitat's angle of inclination to provide an environment for the habitat's crew and cargo in which the resultant gravity vector is normal to the habitat floor at all times. Design of the habitats and modifications to the centrifuge are complete, and are currently under construction. Design philosophy and operational rationale are presented along with complete descriptions of the facility and its systems.
Computer-aided real-time acquisition of physiological data: technical design and selection constraints (1981)

For many years, physiological investigations have utilized the power and speed of analogue, digital and hybrid computers. Complex protocols often require the recording of large amounts of data in short periods, typically with simultaneous fine control of multiple experimental variables. Current systems often include data analysis in the same program which controls data acquisition. Although this is convenient from a package point of view, acquisition and analysis routines have different and sometimes conflicting purposes and requirements. This paper examines acquisition of continuous physiological signals by small dedicated computers in an attempt to separate these processes and to provide guidelines for computer selection, design and development.
New Photomechanical Molecular Switch Based on a Linear π-Conjugated System (2017)

We report the electron-transport properties of a new photoaddressable molecular switch. The switching process relies on a new concept based on linear π-conjugated dynamic systems, in which the geometry and, hence, the electronic properties of an oligothiophene chain can be reversibly modified by the photochemical trans–cis isomerization of an azobenzene unit fixed in a lateral loop. Electron-transport measurements through self-assembled monolayers on gold, in contact with an eGaIn top contact, showed switching with a conductance ratio of up to 103. Ab initio calculations were used to identify the most energetically stable conformations of the molecular switch; the corresponding calculated conductances qualitatively explain the trend observed in the photoswitching experiments.
Noncanonical NF-κB Activation by the Oncoprotein Tio Occurs Through a Nonconserved TRAF3-Binding Motif (2013)

Members of the nuclear factor κB (NF-κB) family of transcription factors regulate many cellular functions. Activation of NF-κB signaling is commonly classified as occurring through canonical or noncanonical pathways. Most NF-κB-inducing stimuli, including the viral oncoprotein Tio, lead to a concerted activation of both NF-κB pathways; however, extensive crosstalk at multiple levels between these signaling cascades restricts the ability to discriminate between the canonical and the noncanonical effects. We showed that noncanonical NF-κB activation by Tio depends on a distinct sequence motif that directly recruits tumor necrosis factor receptor-associated factor 3 (TRAF3). Through its TRAF3-binding motif, Tio triggered a ubiquitin-independent depletion of TRAF3 from the cytosol, which prevented TRAF3 from inhibiting signaling through the noncanonical NF-κB cascade. Furthermore, the Tio-TRAF3 interaction did not affect components of the canonical NF-κB signaling pathway or the expression of target genes; thus, Tio induced noncanonical NF-κB independently of crosstalk with the canonical pathway. Together, these data identify a distinct molecular mechanism of noncanonical NF-κB activation that should enable studies into the particular functions of this pathway.
Alterations in membrane-associated CD14 expression and the simultaneous liberation of soluble CD14 fragment in adherent macrophages mediated by a leukocyte carboxyl/aspartate protease (2002)

Investigations sought to discover the biochemical mechanisms in macrophages that mediate the 'shedding' of soluble CD14 fragment. Stimulated macrophages display both increased liberation of soluble CD14 fragment and decreases in residual membrane-associated CD14 complexes following exposure to activating agents (fMLP/A23187). Application of 'class-specific' protease inhibitors revealed that a thiol/cysteine was involved in the biochemical production of soluble CD14 fractions and that a metalloprotease enzymatically degraded soluble CD14 fragment. Exposure of macrophages to individual proteases revealed that both cathepsin-D and elastase promoted variable depletion of membrane-associated CD14 complexes. Additionally, cathepsin-D, and to a lesser extent elastase, generated soluble CD14 fragment. Related studies isolated a carboxyl/aspartate protease from activated macrophages using pepstatin-A affinity chromatography. The physical and functional properties of macrophage pepstatin-A binding protein fractions closely corresponded with the known characteristics of cathepsin-D with respect to: (i) cellular origin; (ii) binding-avidity of carboxyl/aspartate proteases for pepstatin-A; (iii) non-specific proteolysis of haemoglobin detected by Hb-PAGE zymography; and (iv) hydrolysis of a synthetic cathepsin-D-specific peptide substrate. Interpretation of these findings collectively implies that activated leukocytes can biochemically alter membrane-associated CD14 complex expression and promote the liberation of soluble CD14 fragment in both activated and non-activated cell populations.