gebhart/patrepeval huggingface dataset:
Extracellular Signal-Regulated Kinase Positively Regulates the Oncogenic Activity of MCT-1 in Diffuse Large B-Cell Lymphoma (2009)

The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is highly expressed in 85% of human diffuse large B-cell lymphomas (DLBCL) and that knocking down MCT-1 by a specific short hairpin RNA in DLBCL cells induces apoptosis, supporting a critical role for MCT-1 in DLBCL cell survival. However, the mechanism underlying MCT-1 regulation is largely unknown. We find that MCT-1 is phosphorylated and up-regulated by extracellular signal-regulated kinase (ERK). Furthermore, by using a small inhibitory molecule targeting ERK, we interrupted MCT-1 phosphorylation and stability. Significantly, cells with distinct levels of MCT-1 protein displayed differential sensitivity to ERK inhibitor-induced apoptosis. Treatment with the ERK inhibitor showed marked in vivo antitumor activity in a human DLBCL xenograft model. Our findings establish a functional molecular interaction between MCT-1 and the MEK/ERK signaling pathway and suggest that the activation of MCT-1 function by its upstream kinase ERK plays an important role in lymphomagenesis.
Ventilatory Muscle Function (2002)

Normal ventilation is accomplished by the respiratory muscles overcoming forces that oppose volume movement: lung and chest wall compliance, and airway resistance. In general, venilatory muscle dysfunction is a result of an imbalance between energy demands and energy availability. Energy demands are defined by the interrelationship among ventilatory muscle strength, work of breathing, and ventilatory muscle efficiency. Energy availability is determined by the relationship between energy supply and the bodys' energy stores. In mechanically ventilated patients, dyssynchrony between the patient and ventilator is commonly considered a result of the patients' inbility to work with the mechanical ventilator. However, dysynchrony can be a result of problems with the artificial airay, the mechanical ventilator, or the patient. The cause of dyssynchrony is frequently not a result of a change in the paients' clinical status.
Evaluation of Geothermal Potential, Albuquerque Area, New Mexico: ABSTRACT (1981)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Ligand‐Stabilized Hairpin Structures Interfere with Elongation of Human Telomere (2008)

No way! Naphthyridine tetramer (NT) can bind to G–G mismatches produced by the pairing of two GGG units in hairpin secondary structures, which are a possible intermediate in the folding of telomeres into G quadruplexes. Here we report that NT-stabilized hairpin structures in the telomere can interfere with DNA synthesis by Taq DNA polymerase (see figure). With its unique sequence preference, NT could be used to gain deeper insight into the biological consequence of ligand–telomere interactions. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2008/z700667_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Activation measurements of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Li</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>7</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math>(p,n)<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Be</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>7</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math>reaction from 60—480 MeV (1984)

Activation measurements of the $^{7}\mathrm{Li}$(p,n)$^{7}\mathrm{Be}$(g.s.+ 0.43 MeV) total reaction cross section have been made at proton energies of 60---480 MeV. The energy dependence of the total reaction cross section, ${\ensuremath{\sigma}}_{T}(E)$, is observed to vary inversely with the incident proton energy up to 480 MeV. These results are consistently lower than those reported earlier by Ward et al. in the energy range of 100-200 MeV, the difference being due to the composite nature ($^{7}\mathrm{Li}$Cl) of the targets used in the earlier study. The lithium activation, isospin Clebsch-Gordan ratio, and Monte Carlo code methods for determining neutron efficiencies are now in good agreement (\ifmmode\pm\else\textpm\fi{}10%) up to 200 MeV.
Complex Defect Structure in the Core of Sn-Doped In<sub>2</sub>O<sub>3</sub> Nanorods and Its Relationship with a Dislocation-Driven Growth Mechanism (2011)

Sn-doped In2O3 arrow-shaped nanorods have been grown by a catalyst-free evaporation–deposition method. Transmission electron microscopy (TEM) investigations reveal a complex defect structure consisting of nanoprecipitates, dislocation loops, and voids, in the core of the nanorods, extending all along the growth axis. The nanoprecipitates are Sn or Sn-rich and appear sometimes associated with small voids. The voids appear aligned in rows or discontinuous empty nanochannels along the nanorod core. TEM images depict the presence of surface ripples perpendicular to the growth direction, with typical distances of less than 10 nm. The relationship of the observed defect structure with a dislocation-driven growth of the nanorods is discussed.
<title>Optimization of surface finish of 8-m class ULE glass telescope mirror blanks for lifetime mechanical reliability</title> (1996)

The mechanical reliability of 8 m class ULE<SUP>TM</SUP> glass telescope mirror blanks is a key requirement for both the blank manufacturer and end-user. The massive monolithic blank experiences stresses during the various manufacturing steps including handling, grinding, sagging, and finishing. Likewise, it is subjected to vibrational loads and road shocks during transportation to end-user. And finally, it experiences transient stresses during installation and steady-state static stresses throughout its useful life in service. The large blank, which weighs nearly 35 tons, must have appropriate surface finish to sustain manufacturing, transportation, installation and service stresses with low probability of flaw initiation and propagation. This paper examines the critical stress/time histories the blanks experience during manufacturing and their ability to initiate slow crack growth from grinding flaws. Two different surface finishes, namely 120 grit and 270/325 grit, with and without acid etching are characterized with respect to strength, flaw, and fatigue behavior. These data show that the 270/325 grit finish with acid etching is appropriate for the sagging step which imposes a static stress of 750 psi in the center region of the mirror blank over a two-week sag period. Similarly, the 120 grit surface finish is adequate for grinding, packaging and transporting steps which impose a static stress of 435 psi in the support pad region for a three-month period. These predictions, based on Power law fatigue model, were verified by conducting static fatigue tests (at appropriate stress levels) on a large sample of 6' diameter ULE<SUP>TM</SUP> discs (with appropriate surface finish) at 25 degree(s)C and 100% RH. Such a verification is imperative for selecting appropriate surface finishes for the mirror blanks to promote mechanical reliability during manufacturing and service.
Functional and Morphological Correlations before and after Video-Documented 23-Gauge Pars Plana Vitrectomy with Membrane and ILM Peeling in Patients with Macular Pucker (2015)

Purpose. To assess functional and morphological alterations following video-documented surgery for epiretinal membranes. Methods. Forty-two patients underwent video-documented 23-gauge vitrectomy with peeling of epiretinal (ERM) and inner limiting membrane (ILM). Patient assessment was performed before and 3 and 6 months including best corrected visual acuity (BCVA), slit lamp biomicroscopy, SD-OCT, and central 2° and 18° microperimetry. In addition, all video-documented areas of peeling on the retinal surface were evaluated postoperatively using an additional focal 2° microperimetry. Retinal sensitivity and BCVA were correlated with morphological changes (EZ and ELM) in the foveal region and in regions of membrane peeling. Results. Overall, BCVA increased from 0.6 (±0.2) to 0.2 (±0.2) logMAR after 6 months with an increase in retinal sensitivity (17.9 ± 2.7 dB to 26.8 ± 3.1 dB, p < 0.01). We observed a significant correlation between the integrity of the EZ but not of the ELM and the retinal sensitivity, overall and in peeling areas (p < 0.05). However, no significant correlation between alterations in the area of peeling and overall retinal sensitivity regarding visual acuity gain could be observed after 6 months (p > 0.05). In contrast, overall postoperative retinal sensitivity was significantly decreased in patients with a visual acuity gain lower than 2 lines (p < 0.05) correlating with EZ defects seen in OCT. Conclusions. Mechanical trauma of epiretinal membrane and ILM peeling due to the use of intraocular forceps may affect the outer retinal structure. Nevertheless, these changes seem to have no significant impact on postoperative functional outcome.
Relationship between endotoxin antibody levels and portal systemic shunt evaluated by per‐rectal portal scintigraphy (1994)

The reasons for the high frequency of endotoxaemia in cirrhosis, whether poor liver function or abnormal portal circulation, are not known. Accurate measurement of endotoxin itself is difficult. Instead, in this study an enzyme-linked immunosorbent assay was used to measure levels of IgA, IgG and IgM antibodies to endotoxin in patients with chronic liver disease and underlying hepatic viral infection. The relationships between the results and clinical symptoms or the presence of a portal systemic shunt were investigated. The median level of IgA antibodies was not different in patients with chronic hepatitis and those with cirrhosis, and the same was found for IgM, but the median level of IgG antibodies was significantly higher in the patients with cirrhosis. When patients with cirrhosis were grouped by the presence or absence of ascites or hepatocellular carcinoma, no significant difference was observed in any of these antibody levels. However, in cirrhotic patients with varices, the level of IgG antibodies to endotoxin was significantly higher than in patients without varices. For evaluation of the portal systemic shunt, the per-rectal portal shunt index was calculated. There was a significant correlation (R = 0.431, P < 0.001) between the per-rectal portal shunt index and the level of IgG antibodies to endotoxin. That is, the degree of abnormality in the portal haemodynamics was correlated with the level of IgG antibodies to endotoxin in patients with liver disease.
Study of Secondary Reactions in Gas Phase During the Pyrolysis of Zinc Salts (1967)

Journal Article Study of Secondary Reactions in Gas Phase During the Pyrolysis of Zinc Salts Get access Guy Pannetier, Guy Pannetier Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerald Djega-Mariadassou Gerald Djega-Mariadassou Laboratoire de Cinetique Chimique, 1 rue Guy de la Brosse, Paris 5°, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Chromatographic Science, Volume 5, Issue 9, September 1967, Pages 471–476, https://doi.org/10.1093/chromsci/5.9.471 Published: 01 September 1967 Article history Received: 26 October 1965 Published: 01 September 1967
On Decision Procedures for Set-Value Fields (2004)

An important feature of object-oriented programming languages is the ability todynamically instantiate user-defined container data structures such as lists, trees,and hash tables. Programs implement such data structures using references todynamically allocated objects, which allows data structures to store unboundednumbers of objects, but makes reasoning about programs more difficult. Reasoningabout object-oriented programs with complex data structures is simplified if datastructure operations are specified in terms of abstract sets of objects associatedwith each data structure. For example, an insertion into a data structure in thisapproach becomes simply an insertion into a dynamically changing set-valued fieldof an object, as opposed to a manipulation of a dynamically linked structure linkedto the object.In this paper we explore reasoning techniques for programs that manipulate datastructures specified using set-valued abstract fields associated with container objects.We compare the expressive power and the complexity of specification languagesbased on 1) decidable prefix vocabulary classes of first-order logic, 2) twovariablelogic with counting, and 3) Nelson-Oppen combinations of multisortedtheories. Such specification logics can be used for verification of object-orientedprograms with supplied invariants. Moreover, by selecting an appropriate subsetof properties expressible in such logic, the decision procedures for these logics yieldautomated computation of lattice operations in abstract interpretation domain, aswell as automated computation of abstract program semantics.
The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity (2017)

A chemical genomics "Toxmatrix" method was developed to elucidate mechanisms of cytotoxicity using neuronal models. Quantitative high-throughput screening (qHTS) was applied to systematically screen each toxicant against a panel of 70 modulators, drugs or chemicals that act on a known target, to identify interactions that either protect or sensitize cells to each toxicant. Thirty-two toxicants were tested at 10 concentrations for cytotoxicity to SH-SY5Y human neuroblastoma cells, with results fitted to the Hill equation to determine an IC<sub>50</sub> for each toxicant. Thirty-three toxicant:modulator interactions were identified in SH-SY5Y cells for 14 toxicants, as modulators that shifted toxicant IC<sub>50</sub> values lower or higher. The target of each modulator that sensitizes cells or protects cells from a toxicant suggests a mode of toxicant action or cellular adaptation. In secondary screening, we tested modulator-toxicant pairs identified from the SH-SY5Y primary screening for interactions in three differentiated neuronal human cell lines: dSH-SY5Y, conditionally immortalized dopaminergic neurons (LUHMES), and neural stem cells. Twenty toxicant-modulator pairs showed pronounced interactions in one or several differentiated cell models. Additional testing confirmed that several modulators acted through their primary targets. For example, several chelators protected differentiated LUHMES neurons from four toxicants by chelation of divalent cations and buthionine sulphoximine sensitized cells to 6-hydroxydopamine and 4-(methylamino)phenol hemisulfate by blocking glutathione synthesis. Such modulators that interact with multiple neurotoxicants suggest these may be vulnerable toxicity pathways in neurons. Thus, the Toxmatrix method is a systematic high-throughput approach that can identify mechanisms of toxicity and cellular adaptation.
Synthesis of 9-bromo derivatives of 4,5-, 2,7-, and 3,6-dimethyl- and 2,4,5,7- and 3,4,5,6-tetramethylphenanthrenes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 9-bromo derivatives of 4,5-, 2,7-, and 3,6-dimethyl- and 2,4,5,7- and 3,4,5,6-tetramethylphenanthrenesMelvin S. Newman and Kenneth C. LiljeCite this: J. Org. Chem. 1979, 44, 26, 4944–4946Publication Date (Print):December 1, 1979Publication History Published online1 May 2002Published inissue 1 December 1979https://doi.org/10.1021/jo00394a041RIGHTS & PERMISSIONSArticle Views843Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (435 KB) Get e-Alerts Get e-Alerts
OL-020 Clinico-bacteriological studies in Erythema multiforme and the role of Mycoplasma pneumoniae (2010)

Background: Centre for Health Protection in Hong Kong advocates healthcare workers to wear N95 respirators during the outbreak of infectious respiratory diseases. Nevertheless, it is evident that the effectiveness of N95 respirator is contingent upon its fitness to the wearer. This study, therefore, aims to explore the undergraduate Chinese nursing students' fitness for N95 respirators in Hong Kong. Methods: A cross-sectional descriptive and prospective design was used in this study. Convenience sampling was adopted to solicit 204 undergraduate nursing students to participate in the study. Two types of N95 respirators, namely 3M 1860s and 3M 1862, were being used to test their fitness for each participant. A quantitative fit testing device, the PortaCount Respirator Fit Tester System which is recommended as the international gold standard in determining the fitness of respirators, was used to measure the users' fitness for those two types of respirator. "Fit factor" was then calculated. A score over 100 was considered as pass, and the respirator was said to be fitted for the participant. Results: 61.3% (n = 125) and 57.4% (n = 117) of the participants were found to be fitted for 3M 1860s and 3M 1862 respirator respectively. 81.4% (n = 166) of the participants passed the fit test in either one of the models. Only 37.3% (n = 76) of the participants were found to be fitted for both models. The use of Chi Square also indicated that there was no association between the fitness for these two models of respirator (X 2 = 1.57, p = 0.134). Conclusion: Only one third of undergraduate Chinese nursing students are fitted for both 3M 1860s and 3M 1862 N95 respirators. Most of the students could only fit for either one model. Therefore, fitness must be ensured via the conduction of fit test to confirm the type of respirators that could offer maximum protection for the students.
New Super‐ and Supramolecular Receptor Systems: Cages, Chains, Squares, and Dendrimers Incorporating Macrocycles as Structural Elements (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Detection of high nerve growth factor serum levels in AIDS-related and -unrelated Kaposiʼs sarcoma patients (1998)

These results strongly suggest that increased NGF levels, possibly related to HHV-8 infection, may be involved in KS progression.
Field Application of Relative Permeability Modifier in Venezuela (2002)

For many years, relative permeability modifiers (RPM's) have received a great deal of attention from the oil and gas industry. Because of the completion techniques used in many wells, protecting the hydrocarbon interval properly during a watershutoff treatment is not always practical or cost effective. RPM's offer the option of bullheading a treatment without zonal isolation, which is designed to decrease water production with little or no decrease in oil or gas production.This paper describes the laboratory development and optimization of a polymeric RPM. The resulting material can best be described as a brush polymer consisting of a polymeric backbone grafted with methoxypolyethylene glycol (MPEG). Various phases of the development are discussed, and an overview of the laboratory evaluations is also provided. These test results indicate that the RPM polymer should be placed with a systematic approach consisting of proper preflushes and post-flushes for optimum results. A field case study in which the system was used in Venezuela is provided, along with the subsequent results of the treatment.
Phosphorylation of yeast phosphatidylserine synthase in vivo and in vitro by cyclic AMP-dependent protein kinase. (1988)

Evidence is presented that demonstrates that phosphatidylserine synthase (CDPdiacylglycerol:L-serine O-phosphatidyltransferase, EC 2.7.8.8) from Saccharomyces cerevisiae is phosphorylated in vivo and in vitro by cAMP-dependent protein kinase. Phosphatidylserine synthase activity in cell extracts was reduced in the bcy1 mutant (which has high cAMP-dependent protein kinase activity) and elevated in the cyr1 mutant (which has low cAMP-dependent protein kinase activity) when compared with wild-type cells. The reduced phosphatidylserine synthase activity in the bcy1 mutant correlated with elevated levels of a phosphorylated form of the phosphatidylserine synthase Mr 23,000 subunit. The elevated phosphatidylserine synthase activity in the cyr1 mutant correlated with reduced levels of the phosphorylated form of the enzyme. There was negligible phosphorylation of the phosphatidylserine synthase Mr 23,000 subunit from stationary-phase cells. Pure phosphatidylserine synthase was phosphorylated by the cAMP-dependent protein kinase catalytic subunit, which resulted in a 60-70% reduction in phosphatidylserine synthase activity. The cAMP-dependent protein kinase catalytic subunit catalyzed the incorporation of 0.7 mol of phosphate per mol of phosphatidylserine synthase Mr 23,000 subunit. The specific cAMP-dependent protein kinase inhibitor prevented the phosphorylation of phosphatidylserine synthase and the inhibition of its activity by the catalytic subunit. Analysis of peptides derived from protease-treated labeled phosphatidylserine synthase showed only one labeled peptide. Phospho amino acid analysis of labeled phosphatidylserine synthase showed that the enzyme was phosphorylated at a serine residue.
Piecewise-linear maps (2000)

Chaotic signals generated by iterating piecewise-linear (PWL) maps on the unit interval are highly attractive in a wide range of signal processing applications. In this letter, optimal estimation algorithms for signals generated by iterating PWL maps and observed in white noise are derived based on the method of maximum likelihood (ML). It is shown how the phase space of the map may be decomposed into a number of regions and how the estimation problem is linear in each of these regions. The final ML estimate is obtained as the best performing of these "local" solutions.