gebhart/patrepeval huggingface dataset:
Increased Intracranial Pressure and Pulmonary Edema (1968)

CARD1OVASCULAR response to raised intracranial pressure was first noted in the nineteenth century. 1~ Cushing gave meaning to this response when he demonstrated that the diastolic blood pressure always rose to a level slightly greater than that of the intracranial pressure5 This pressor response thus serves to maintain the circulation within the cranial cavity. Several groups of investigators have further characterized aspects of the hemodynamic response to increases in intracranial pressure; 2-4'(;'7'1j'I ~'16''-'~' however, none has studied the cardiovascular response that occurs with graded elevations in intracranial We have recently encountered 11 patients with pulmonary edema associated with increased intracranial pressure in the absence of concomitant cardiovascular or pulmonary disease. ~ These patients were all young, ranging in age from 12 to 44 years. Our laboratory experience has indicated that pulmonary edema can be elicited in about 20% of normal dogs and monkeys by the sustained elevation of intracranial pressure. The present experiments were performed to delineate both the systemic and pulmonary hemodynamic responses of higher primates to graded increases in intracranial pressure and thereby to understand both the Cushing reflex and the finding of pulmonary edema.
Microstructuring system SiO<sub>2</sub>/Si with nanosecond pulsed fiber laser (2013)

The formation of morphological structures on system SiO<sub>2</sub>/Si by pulsed ytterbium fiber laser has been investigated. The resulting structures are investigated by atomic force microscopy. It is shown that during irradiation on surface of the monocrystalline silicon wafer covered by a thin layer of thermally grown silicon dioxide (SiO<sub>2</sub>), there are significant structural changes associated with localization on the surface of the silicon strips of slip-lines and grid of slip-line formed by the intersection of these strips. It is also shown that exposed to laser radiation in the silicon-silicon dioxide system there are structural changes that lead to the change of the electrophysical properties of SiO<sub>2</sub>/Si system. Changes in electrophysical properties of the oxide and the interface are more observed in the area of direct exposure to the laser beam on the silicon substrate where there are maximum structural changes of the silicon surface manifested in the form of a lattice slip lines. It is found that there are laser-induced defects in areas remote from the irradiation zone.
The Effect of Suture Technique on Adhesion Formation after Flexor Tendon Repair for Partial Lacerations in a Canine Model (2001)

High friction suture techniques may cause more adhesion formation than the lower friction suture techniques under passive postoperative therapy.
Nanocrystallization in Oxyfluoride Glasses Controlled by Amorphous Phase Separation (2015)

Transparent bulk glass-ceramics containing ZnF2, K2SiF6, and KZnF3 nanocrystals are successfully obtained from xKF-xZnF2-(100 - 2x)SiO2 oxyfluoride glasses for the first time to the best of our knowledge. The glass transition temperatures of heat-treated samples increase with time and approach values that resemble the temperatures chosen for thermal treatment. During nucleation and crystal growth, the residual glass around the crystals is depleted in fluoride which as glass component usually leads to a decrease in viscosity. The crystallization behavior notably depends on the glass composition and changes within a small range from x = 20 to 22.5 mol %. The occurrence of liquid/liquid phase separation in dependence of the composition is responsible for the physicochemical changes. Two different microstructures of droplet and interpenetrating phase separation and their compositional evolution are observed by replica transmission electron microscopy technique in the multicomponent glassy system. This study suggests that the size and crystal phase of precipitated crystallites can be controlled by the initial phase separation.
ChemInform Abstract: Dithiaheterocycle‐Annelated Tetrathiafulvalene π‐Donors: A Structure‐Property Correlation Study. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Investigation of Simultaneous Immunoassay by a Two-dimensional Surface Plasmon Resonance Sensor Using Multiplied Beam Splitting Optics (2016)

We have developed a two-dimensional surface plasmon resonance (SPR) sensor using multiplied beam-splitting optics. In this study, we evaluated immunoassays by the SPR sensor. As a result, we could measure the change of the reflected-light intensity in real time, which is based on the immobilization of an antibody onto the surface of the sensor chip, the adsorption of a blocking reagent onto the surface, and specific bonding of the antigen to the antibody immobilized on the sensor chip. The calibration curve for IgA was linear under a concentration of 6.0 μg mL−1, and a quantitative immunoassay was successfully accomplished by the SPR sensor. We also fabricated a sensor chip in which anti-IgA, anti-IgG and anti-IgM were immobilized on the detection point in the flow channel on the sensor chip, respectively. We then evaluated measurements of IgA, IgG and IgM using the sensor chip. When a sample solution containing IgA was introduced into the flow channel, the reflected light intensity at the detection point at which anti-IgA was immobilized dramatically increased, whereas the reflected light intensity at the detection point at which anti-IgG or anti-IgM was immobilized did not change. Similarly, in the case of IgG and IgM, the reflected light intensity only increased at the detection point at which corresponding antibody was immobilized. These results indicate that a simultaneous immunoassay by the SPR sensor should be possible.
Phase separation and superconductivity in La[sub 2]CuO[sub 4+[delta]]: Effects of oxygen diffusion (1993)

In oxygen-annealed La[sub 2]CuO[sub 4+[delta]] ([delta][approximately]0.03), bulk magnetization measurements show an increase of [approximately]4K in the superconducting T[sub c] when the sample is cooled slowly through a narrow temperature range near 195K. At this temperature, [sup 139]La NQR spectra exhibit a concomitant appearance of an anomalous feature associated with the metallic phase whose spectral weight increases with cooling rate. The data suggests a distribution of local structures and annealing-dependent volume fraction on this part of the sample. Interpretation of these results in terms of oxygen diffusion in a phase separated material is considered and a picture consistent with the observed changes in T[sub c] is obtained. Other possible origins of these anomalies and the role they play in determining the superconducting properties of this system are discussed.
Surface emitting SHG light by counter propagation of guided waves in a plane parallel poled DANS side chain polymer (1995)

Large nonlinear optical coefficients and easy processing and fabrication techniques make organic materials, especially polymers, very attractive condidates for counter propagating mixing applications. Here a spincoated waveguide based on a 4‐dimethylamino‐4'‐nitrostilbene side chain polymer is shown to generate surface emitted second harmonic light. The preparation of the waveguide, its experimental operation, and the theoretical background are discussed.
Development of an Innovative and Eco-Friendly UV Radiation Absorber, Based on Furan Moieties (2020)

The increasing concern about the environmental impact of ingredients largely used as sunscreens today is pushing research towards new frontiers for the synthesis and degradation potential of innovative sun protection structures. This study deals with the design, synthesis, efficacy evaluation, and environmental impact of new photo-stable molecules at extended electronic conjugation and which have the ‘charge-transfer’ type of optical transition (push and pull). They efficiently perform absorption of electro-magnetic radiation in the UVB and UVA regions. A preliminary screening, dealing with a whole series of aromatic donors, led to the selection of a key substrate derived from waste material, provided with low environmental impact and largely available on the market. As far as the acceptor was concerned, an ester with cyan-acrylic structure and functionalized with aliphatic chains emerged as the most suitable. This allowed a shift of the λ of absorption in the range of the ultraviolet wavelengths. The synthesis procedures include an acid-catalyst-fitted esterification, condensation, and cold crystallization. It was continuously monitored with suitable characterization instruments (GC-MS, 1H NMR, 13C NMR), in order to avoid by-products and parasitic reactions. The resulting structures (patent pending) are composed by a furan core condensed with cyano-acrylic esters, derivatized with branched chains of hydrocarbons of medium length. The obtained structures are capable of good absorption in the range of wavelengths between 300 and 400 nm. Because of their structures, the new molecules are largely soluble in many common oils and cosmetic ingredients. The new molecules have been successively evaluated in terms of photo-stability, biodegradability, compatibility, and UVB-UVA protection capability, both in-vivo and in-vitro, in comparison with existing sunscreens.
Tripodal Tris-Urea Derivatives as Gelators for Organic Solvents (2000)

Several new tripodal tris-urea derivatives are prepared and found to be efficient gelling agents for organic solvents. The structure and thermotropic properties of the gels are studied by electron microscopy, differential scanning calorimetry (DSC) and FT-IR spectroscopy. Remarkably, the range of solvents to be gelled can be tuned by the peripheral substituents.
Identification of twelve novel mutations in patients with classic and variant forms of maple syrup urine disease (2003)

Maple syrup urine disease (MSUD) is an autosomal recessive metabolic disorder of panethnic distribution caused by a deficiency of the activity of branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. Mutations in the human BCKD genes E1alpha (BCKDHA), E1beta (BCKDHB) and E2 (DBT) are known to result in MSUD, referred to as type Ia, Ib and II mutations respectively. In this study 16 patients with the classic severe form of MSUD and three patients with milder variant forms of the disease were investigated for mutations in the E1alpha-, E1beta- and E2-gene by single-strand conformation polymorphism (SSCP) analysis and DNA sequencing. The patients' clinical and biochemical phenotypes were well characterized. One novel type Ia missense mutation, eight novel type Ib (three missense, two nonsense, two small deletions, one small duplication) and three novel type II (two missense, one splice site) mutations were identified in patients. Moreover, eleven previously described mutations were detected: five type Ia (four missense, one nonsense), three type Ib mutations (two missense, one nonsense) and three type II mutations (two missense, one small deletion). Fourteen patients are homozygous for one single mutation, five patients are compound-heterozygous for two different mutations affecting one of the three genes. Thus, in all 19 patients the identified mutations can most probably be considered the molecular basis of the disease.
On the Use of Wavelets for the Implementation of High Order Mesh Refinement in Time Domain Simulations (2000)

Employing high order wavelets for the formulation of time domain schemes via the Method of Moments offers a rather straightforward way to implement high order mesh refinement. However, utmost care is necessary for the correct and computationally efficient formulation of arbitrary order wavelet schemes, especially when geometrically involved devices are to be modeled. This paper outlines the steps towards such formulations and provides numerical examples to evaluate their efficiency and applicability to practical microwave problems.
Thermodynamic model for the solubility of ThO<sub>2</sub>(am) in the aqueous Na<sup>+</sup>-H<sup>+</sup>-OH<sup>-</sup>-NO<sub>3</sub> <sup>-</sup>-H<sub>2</sub>O-EDTA system (2003)

Abstract The solubility of ThO 2 (am) in the aqueous Na + -H + -OH - -NO 3 - -H 2 O-EDTA system as a function of pC H⁺ (= -log[H + ]) and variable NaNO 3 (0.5M to 6.0M) has been determined. The experimental observations show that between pC H⁺ values 4.2 to 8.2, a stoichiometric 1:1 Th-EDTA complex forms that completely saturates the added chelate concentration. Th concentrations then decrease linearly with increasing pC H⁺ at pC H⁺ >9.0. These changes in solubility are not predicted by currently available thermodynamic models. The ion-interaction model of Pitzer was used to interpret these solubility data. Thermodynamic analysis indicates that the speciation under basic conditions is dominated by monomeric mixed Th-OH-EDTA complexes. X-ray absorption near-edge spectroscopy confirmed the absence of the higher order ( e.g. dimeric) species. The equilibrium constants for the following reactions were determined from analysis of the solubility data: ThO 2 (am) + EDTA 4- + 2H 2 O ↔ Th(OH) 2 EDTA 2- + 2OH - , log K = -6.0; and ThO 2 (am) + EDTA 4- + 2H 2 O ↔ Th(OH) 3 EDTA 3- + OH - , log K∼-7.5. Pitzer ion-interaction parameters for the Th(OH) 2 EDTA 2- and the Th(OH) 3 EDTA 3- species were calculated. It was also determined that the solubility method for examining the complexation of tetravalent actinides with EDTA is limited to relatively high aqueous EDTA concentrations, relative to the amount of ThO 2 (am) precipitate, owing to the adsorption of the EDTA chelator by the solid phase.
Ion channel reconstitution in planar lipid bilayers (1987)

In recent years various ionic channels have been reconstituted in planar lipid bilayers by which rigorous analysis of the electrical behavior of single ionic channels can be made. I have reviewed, in the first half of this article, practical techniques for forming planar bilayers and for incorporating channels into them. The second half deals with a structural analysis of the ion conducting pathway of the reconstituted K+ channel from sarcoplasmic reticulum solely by measuring its electrical properties. The electrical analysis of channel structure should be a promissing approach to bridge the gap between the electrical property and the molecular structure of channel proteins in lipid bilayers.
ChemInform Abstract: Synthesis and Biological Activity of Two 1‐Aminoindoloquinolizidines Derivatives on Tyrosine Hydroxylase in the Rat and Mouse Brain. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dipeptidyl peptidase‐4 (DPP4) induce Cellular Senescence in Human Umbilical Cord Blood‐Derived Mesenchymal Stem Cells (2016)

Recently, the number of clinical trials in which mesenchymal stem cells (MSCs)‐based therapy is employed to treat various diseases has increased. A fundamental requirement for these MSCs‐based therapies is the expansion of MSCs during long‐term growth in culture, which is required to obtain a sufficient number of functional cells. However, long‐term growth inevitably arguments cellular senescence, which potentially causes poor clinical outcomes by inducing growth arrest and the loss of stem cell properties in MSCs. Thus, the identification of suitable markers for evaluating the status of MSCs senescence during long‐term culture is crucial. Here, we investigated the surface markers of human umbilical cord blood‐derived MSCs (hUCB‐MSCs) associated with cellular senescence using fluorescence‐activated cell sorting analysis and 242 cell surface‐marker antibodies. Among these surface proteins, we selected dipeptidyl peptidase‐4 (DPP4) which further validated for their expression by flow cytometer analysis. It has been shown that expression of DPP4 was the markedly increased in the aging hUCB‐MSCs. Through sorting analysis and small interfering RNA treatment, the DPP4 positive hUCB‐MSCs had the low rate of cell growth and differentiation potentials, and significantly higher expression of p38, p53, pRb, and β galactosidase‐positive staining, well known markers of senescence. In addition, suppression of DPP4 in hUCB‐MSCs resulted in up‐regulation of stemness genes, including Oct4, Nanog. Interestingly, DPP4 negative hUCB‐MSCs induced to a greater improvement in therapeutic effect by not only promoting the engraftment potential of infused stem cell, but also reducing lung damage in an emphysema mouse model. Taken together, our results demonstrate that DPP4 is a new marker for predicting senescence in hUCB‐MSCs, and it could be valuable in quality‐control assessments and for improving the therapeutic potential of hUCB‐MSCs‐based therapy.
109 Knowledge Acquisition and Job Training of Casting Techniques by Using Interactive Immersive Virtual Environment (2005)

The environment where Japanese industry has been paid with respect is changing tremendously due to the globalization of economics, where Asian countries are undergoing economical and technical development as well as advancing in information technology. For example, in the design of custom-made casting product, a designer whom lacking of casting knowledge may not be able to produce a good design. In order to obtain a good design and manufacturing result, it is necessary to equip the designer and manufacturer with a support system related to casting design or so called, knowledge transfer and creation system. This paper proposes a new virtual reality based knowledge acquisition and job training system for casting design, which is composed of the explicit and tacit knowledge transfer system using synchronized multimedia and the knowledge internalization system using immersive virtual environment. In our proposed system, the education content is displayed in the immersive virtual environment, where by a trainer and trainee may experience in the virtual site operations together. Sharing the content with the trainer who has a master of casting technique, the trainee has gained explicit and tacit knowledge of casting through the multimedia-based knowledge transfer system, the immersive virtual environment catalyzes the internalization of knowledge and also enable the trainee to gain tacit knowledge before undergoing on the job training at real operation site.
Determination of titanium, zirconium, lead and additives in lead zirconate titanate by ICP-AES. (1986)

ICP-AESによりチタン酸ジルコン酸鉛中のチタン,ジルコニウム,鉛及び添加物(ランタン,ニオブ,ストロンチウム,マンガン及びマグネシウム)の多量成分の定量法を検討した.試料をテフロン製加圧容器中で塩酸とフッ化水素酸で分解した後,チタン,ジルコニウム,鉛など沈殿を生成しやすい成分をEDTA・2Naでマスキングして安定な水溶性錯体とした.更に,分解過程で生成するフッ化ランタンの沈殿の再溶解及び過剰なフッ化物イオンのマスキングをホウ酸と硝酸の混液で加熱して行った.これにより,器物の浸食なしに同一の溶液を用いて全元素を迅速に精度良く(相対標準偏差3%以下)定量できた.
Acoustic travel time and intensity fluctuations measured in the SWARM95 experiment (1997)

During the summer of 1995, a multidisciplinary, multilaboratory experiment entitled ‘‘SWARM’’ (shallow-water acoustics in a random medium) was conducted on the continental shelf off New Jersey. The purpose of this experiment was to examine the effects of internal waves, both linear and nonlinear, upon acoustic transmissions in the 10 to 1000-Hz range. Towards this goal, numerous oceanographic sensors were deployed along a fixed across shelf track, together with a fixed acoustic transmission range. Shipborne acoustic sources also allowed out of plane (along shelf) studies. Results will be presented of recent data analyses showing the nature of the measured acoustic travel time and intensity fluctuations, and how they correlate to environmental forcing, particularly by internal waves and the shelfbreak front. [Work supported by ONR.]
Corrosion of Reactor Wall Surfaces by  WF 6 (1994)

The reactions of tungsten hexafluoride on stainless steel, tantalum, platinum, nickel, and Monel 400® were investigated using temperature‐programmed desorption and Auger electron spectroscopy in ultrahigh vacuum. The high reactivity of stainless steel and tantalum surfaces indicate that they are not suitable materials for tungsten chemical vapor deposition reactors. Nickel and Monel 400® are much less reactive and are suitable for use below 800K. Platinum does not react with below 600K and may be suitable for use at higher temperatures. Mass spectrometer cracking patterns for, , and were measured.
Thyroid Function and Alzheimer's Disease (2009)

Thyroid dysfunction has been implicated as a cause of reversible cognitive impairment and as such, the thyroid stimulating hormone has long been part of the screening laboratory test for dementia. Recently, several population-based studies demonstrated an association between hypo- or hyperthyroidism and Alzheimer's disease. This review discusses the role of thyroid hormone in the normal development and regulation of central nervous system functions and summarizes the studies that have linked thyroid function and dementia risk. Finally, it explores possible biological mechanisms to explain this association, including the direct effects of thyroid hormone on cerebral amyloid processing, neurodegeneration and thyrotropin-mediated mechanisms and vascular mediated enhancement of Alzheimer's disease risk.
Sensitive detection of Nampt(PBEF/Visfatin)in human serum for point-of-care applications using aptamer based capacitive biosensor (2012)

NAMPT is a multifunctional protein, also known as visfatin or pre-B cell colony-enhancing factor, which exists as the rate-limiting intracellular enzyme for nicotinamide adenine dinucleotide (NAD) synthesis starting from nicotinamide [1]. The plasma Nampt levels are reported to have correlation with obesity and obese related metabolic disease, such as Type 2 diabetes mellitus (T2DM), cardiovascular diseases [2] and hyperlipidemia [3] due to association with lipoprotein and cholesterol. Therefore, sensitive detection of Nampt potentially enable accurate diagnosis of T2DM, cardiovascular and hyperlipidemia diseases.

In this study, for the first time, we developed an ssDNA aptamer that specifically bind Nampt (Kd=72.52 nM) in human serum by systematic evolution of ligands by exponential enrichment (SELEX) process. Nampt-specific ssDNA aptamers were then applied as the recognition molecules for the development of a capacitive biosensor using non-Faradaic impedance spectroscopy (nFIES), which converts the biological binding event into a quantifiable signal for sensitive and efficient detection of the Nampt (Fig. 1). The interaction of aptamer-Nampt induced the change in dielectric properties, charge distribution, and conductivity. The limit of detection was 1 ng/ml with a dynamic range of upto 50 ng/ml in serum and this range is under the clinical requirements both in the normal Nampt levels, which is 15.8 ng/ml, and in the T2DM patients level, which is 31.9 ng/ml. This assay system for Nampt detection using aptamers is a potential alternative approach for applications in clinical studies and Point-Of-Care health technologies.
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus (1998)

CIPO in SLE is a life threatening situation that can be reversed by treatment. It may be: (a) a complication or onset feature of the disease; (b) secondary to smooth muscle involvement; (c) associated with ureteral and vesical involvement; (d) the result of intestinal vasculitis.