gebhart/patrepeval huggingface dataset:
Median nerve somatosensory evoked potentials and upper limb motor function in hemiparesis. (2003)

The purpose of this study is to describe the relationship between median nerve somatosensory evoked potential (SEP) parameters and clinical measures of motor impairment and physical disability in the affected upper limb of patients with hemiparesis. SEP assessments were carried out in 28 long-term survivors of stroke. Stroke survivors with preserved SEPs over the affected hemisphere exhibited significantly lower motor impairment and physical disability than those with absent waveforms. Among those with preserved waveforms, SEP amplitude exhibited a weak correlation with degree of upper limb motor impairment. The correlation between SEP amplitude and physical disability was not statistically significant. Contrary to prior reports, median nerve SEP appears to have a weak correlational relationship with clinical measures of upper limb function in hemiparesis.
Use of permanent downhole geophones for microseismic surveying of gas storage reservoir (1993)

In most cases, the recording of microseismic activity requires setting the acoustic sensor as close as possible to the emission area. In the oil industry, the depth of the reservoir, the well spacing and the attenuation of the oil and gas saturated layers are the reasons why the acoustic sensors are preferably placed downhole. For hydraulic fracture mapping, an acoustic tool can be run in with a cable. But such a method is not convenient for a long-lasting experiment such as passive surveying of a reservoir.
The laboratory mouse (2001)

Important Biological Features Introduction Stocks and Strains Nomenclature Behavior Anatomic and Physiologic Features Normative Values Hematology Immunodeficient Mice Wild Mice References Husbandry Housing Barriers and Containment Personal Protective Equipment (PPE) Special Considerations for Immunodeficient Mice Environment Sanitation and Pest Control Nutrition Water Breeding Identification and Record Keeping Transportation References Management Regulatory Agencies and Compliance Institutional Animal Care and Use Committee (IACUC) Occupational Health and Zoonotic Diseases References Clinical Medicine Basic Veterinary Supplies Physical Examination of the Mouse Common Spontaneous and Noninfectious Diseases Common Infectious Diseases Treatment and Supportive Care of Sick Mice Clinical Endpoints Treating Disease on a Colony Basis References Preventive Medicine Receiving Testing of Biological Materials Health Surveillance and Monitoring Disease Prevention through Sanitation References Experimental Methodology Restraint Sampling Methods Compound Administration Phenotyping Anesthesia and Analgesia Euthanasia Necropsy References Resources and Additional Information Organizations Publications Electronic Resources Appendix A: Glossary of Phenotyping Terminology and Tests Appendix B: Suggested Cassette Numbering System and Some Trimming Suggestions Index
On the Studies of Antibiotic-resistant Strains of Enterobacteriaceae (1963)

Authors made experiments to isolate antibiotic-resistant strains of Enterobacteriaceae from faeces of 68 healthy persons, who were tested once a month from May 1961 to April 1962. Streptomycin (SM), Tetracycline (TC) and Chloramphenicol (CM) were used as antibiotics. The isolation of resistant bacilli was made by plating on MacConkey media and MacConkey media containing 25γ/ml of one of the antibiotics, three or five colonies being fished from each plate. They were tested their drug resistance on heart infusion agar added 25γ/ml and 100γ/m1 of one of three drugs respectively. The results obtained are as follows:(1) Resistant strains against SM or TC were recovered in markedly greater numbers in summer than in winter, whereas CM resistant bacilli were very few and the seasonal variation of their isolation was, not recognized.(2) The drug-resistance of 4.745 strains isolated were tested; 1.144 strains (24.1%) were revealed to be resistant to 25γ/m1 and about a half (267 strains) of them resistant to over 100γ/ml of one of three drugs.(3) During the observation period, drug resistant bacilli were recovered in 63 persons, but constant carriers were very few. It was only in 6 persons that more than 8 times resistant strains were isolated, and no such strains was not recovered in 5 persons.(4) Only 193 (5.2%) in 3.710 strains recovered on MacConkey agar were drug resistant, these. bacilli were belonging to E. Coli (78.4%), Citrobacter (17.3%), Kledsiella (1.4%) and Proteus (2.9%). The figure of the classification was quite similar to that of the bacilli isolated on MacConkey agar containing drug.(5) Single-resistant strains were most frequently encountered (73.7%), followed by three antibiotics-resistant strains (16.3%) and two-antibiotics-resistant ones (10.5%). The resistant bacilli against various antibiotics over 100γ/ml were isolated in the following percentage order; SM-single-resistant ones in 4.9%, TC-single-resistant ones in 5.4%, SM, TC-resistant ones in 0.9%, SM, CM-resistant ones in 0.6%, TC, CM-resistant ones in 0.1% and SM, TC, CM-resistant ones in 2.3%. These results were not in accordance with those of dysentery bacilli recovered from patients as well as healthy carriers in these days when these experiments were carried out; about 30% of dysentery bacilli were proved to be antibiotic-resistant, moreover almost all of them were multiple-drugs-resistant.
The Role of Statistics in Accounting, Marketing, Finance, and Production (1988)

Robert Hamada, James M. Patell, Richard Staelin, William E. Wecker, The Role of Statistics in Accounting, Marketing, Finance, and Production, Journal of Business & Economic Statistics, Vol. 6, No. 2 (Apr., 1988), pp. 261-272
Carrier acquisition and tracking for Europa relay communications (2018)

In deep space communications, carrier acquisition is pivotal for demodulation of weak signals. Traditionally, NASA's Deep Space Network will sweep the uplink carrier to ensure that the receiver has acquired carrier lock before sending data. In a deep space relay link, the carrier acquisition process will be performed by one of the transponders. Using the Johns Hopkins Applied Physics Laboratory (JHU/APL) Frontier Radio Software Defined Radio architecture, the swept behavior required for unaided carrier acquisition was migrated to the radio's receiver through updates to the algorithms that perform carrier acquisition and tracking. A notional relay link between the NASA Europa Lander spacecraft and the Europa Clipper and Carrier Relay Spacecraft (CRS) is used as a case study for the technique. The nominal center frequency of the carrier acquisition phase-locked loop (PLL) is able to sweep at a user-defined rate within user-defined frequency bounds to ensure that the receiver can lock onto a carrier without the transmitted carrier sweeping through the receivers quiescent frequency. Carrier loop sweeping continues until lock is detected and the loop is switched to a tracking design. The technique that enabled receiver loop sweeping also allows the receiver to accept a Doppler prediction frequency to offset the quiescent frequency of the loop. The turn-around ratio is maintained through the acquisition process, as well as with Doppler prediction offset and tracking. As a result of implementing self-sweeping in the radio receiver, an offset can accumulate in the PLL filter state as the tracking design is nearly Type-II. Furthermore, this offset may compound with repeated acquisitions. The resulting filter state can cause an unwanted offset in the acquisition frequency of the loop. Since the internal state of the loop filter is not directly accessible in the Frontier Radio architecture, this state must be bled-off by temporarily altering the design of the second-order PLL to one with very short time constants. This bleed-off loop is applied at the beginning of each acquisition sequence for a short period of time, then the nominal loop parameters are reapplied before sweeping commences. Algorithms and analysis of the techniques are described below.
The Influence of the Mean Stress on the Propagation of Fatigue Cracks in Light Alloy Sheet (1967)

Clad 2024‐T3 and 7075‐T6 sheet specimens were loaded at three different load amplitudes and three different mean loads. It turned out that the mean stress had an important influence on the crack propagation rate. The crack growth rate in the 7075 specimens was three to four times as large as in the 2024 specimens.
Studies on the Fine Structure of Starch Molecules and Novel Starch Related Enzymes. (1993)

Researches on structural analysis, physical properties of starch and discoveries of novel starch related enzymes are summarized in this paper as an award address. 1) Physical properties and utilization of various starches Starch phosphate derivatives obtained by chemical synthesis or simple cation substitution of naturally existing phosphate of potato starch are discussed in terms of physical properties and possible utilization. Sago starch as a. neglected starch resource in tropical area and newly developed methodology during the study such as photopastegraphy, Q-amylase/pullulanase method (BAP method) are also described. 2) Fine structure of amylopectin: Fine structures of waxy maize starch were analyzed by structure of a-limit dextrin, X-ray diffraction and enzymic structural analysis of Naegeli amylodextrin, transmission electron microscopy and computer modeling. From the results of these studies, French proposed?gcluster model?hfor amylopectin molecules and Kainuma and French proposed?gdouble helix?hconformation for crystalline part of amylopectin. In 1980, Kainuma represented schematic arrangement of amylopectin molecules within a growth ring. 3) Novel starch related enzymes and oligosaccharides: During structural analysis, exo-maltohexaohydrolase (E. C. 3.2.1.98) was unexpectedly discovered as a contaminant of A. aero genes pullulanase. Since this discovery, our research efforts were concentrated to screen new starch related enzymes and enzymatic preparation of oligosaccharides. As the results, cyclodextrins and branched cyclodextrins, isomaltose, maltohexaose, erythritol -a noncaloric sweetener-were already commercially manufactured. Raw starch hydrolyzing glucoamylase of Chalara paradoxa isolated from sago palm tree in Papua New Guinea is expected for energy-saving saccharification of starch.
IV (2008)

<sc>In</sc> the drawing-room after dinner the girl found a chance to approach Owen’s late preceptor. She stood before him a moment, smiling while she opened and shut her fan, and then said abruptly, raising her strange eyes: 'I know what you've come for, but...
Neuromodulation (2017)

This chapter addresses the indications for and complications related to surgical, pharmacologic, and adjunctive neuromodulation therapy. Many forms of neuromodulation therapy find their inspiration from the landmark work by Melzack and Wall in 1965 that described the gate theory of pain. Fifty years later, technological and pharmaceutical progress leads the charge on this exciting field within pain medicine. As understanding of the generation, transmission, and interpretation of pain signaling expands, the options for interventional and medical therapy will surely follow suit. These advancements are a welcome addition as the aging population meets a medical community seeking to curb chronic opioid therapy. The questions in this chapter serve as a guide to the salient neuromodulation techniques, but an emphasis should be placed on the suggested readings in this chapter to develop a more thorough understanding of the topic and variety of techniques and pharmacotherapy not covered.
Water-Dispersible Polyaniline Electrodes for Thin-Film Transistors (2005)

Earlier studies have identified at least two distinct subgroups of alcoholics: Type II with early onset and high genetic loading and Type I with late onset in which genetic factors seem to be of minor importance. In the present study, type I and type II alcoholics are compared on stable personality traits determined by the Karolinska Scales of Personality. Both groups were found to have high scores on scales that measured somatic anxiety, psychic anxiety, muscular tension, impulsiveness, detachment, psychastenia, suspicion, guilt and inhibition of aggression. Both groups had low scores on the scale that measured socialization. Type II alcoholics had significantly higher scores than type I alcoholics on Somatic Anxiety and Verbal Aggression scales and significantly lower scores on Socialization and Inhibition of Aggression scales. On the Impulsive Sensation-Seeking Psychopathy factor (Impulsiveness + Monotony Avoidance - Socialization), type II alcoholics were significantly differentiated from both type I alcoholics and healthy volunteers. Results of this study were consistent with those of other studies indicating that alcoholism accompanied by antisocial behavior should be kept separate from alcoholism that is unrelated to antisocial behavior.
ACUTE HUMORAL REJECTION IN RENAL ALLOGRAFT RECIPIENTS: I. INCIDENCE, SEROLOGY AND CLINICAL CHARACTERISTICS1 (2001)

More than one-third of the patients with steroid-insensitive AR had evidence of AHR, often resistant to antilymphocyte therapy. Most cases (95%) with DSA at the time of rejection had widespread C4d deposits in peritubular capillaries, suggesting a pathogenic role of the circulating alloantibody. Combined DSA testing and C4d staining provides a useful approach for the early diagnosis of AHR, a condition that often necessitates a more intensive therapeutic rescue regimen.
Targeting to the endoplasmic reticulum in yeast cells by determinants present in transmembrane domains. (1998)

International audience
Efficient Glycosidation of a Phenyl Thiosialoside Donor with Diphenyl Sulfoxide and Triflic Anhydride in Dichloromethane. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supporting and Sponsoring Organisations (2007)

Code inspection and unit testing are two popular fault- detecting techniques at unit level. Organizations where inspections are done generally supplement it with unit testing, as both are complementary. A natural question is the order in which the two techniques should be exercised as this may impact the overall effectiveness and efficiency of the verification process. In this paper, we present a controlled experiment comparing the two execution-orders, namely, code inspection followed by unit testing (CI-UT) and unit testing followed by code inspection (UT-CI), performed by a group of fresh software engineers in a company. The subjects inspected program-units by traversing a set of usage scenarios and applied unit testing by writing JUnit tests for the same. Our results showed that unit testing can be more effective, as well as more efficient, if applied after code inspection whereas the later is unaffected of the execution- order. Overall results suggest that sequence CI-UT performs better than UT-CI in time-constrained situations.
Occurrence of isomeric dehydrocholesterols in human plasma. (1991)

Three isomeric dehydrocholesterols were found in plasma from healthy subjects and patients with abnormal production or metabolism of cholesterol. These chemically labile steroids were isolated by a mild liquid-solid extraction procedure using octadecylsilane-bonded silica as sorbent. Sterol-protein interactions were minimized by diluting plasma with aqueous isopropanol. The dehydrocholesterols were identified by high-performance liquid chromatography-ultraviolet spectroscopy and gas chromatography-mass spectrometry as cholesta-5,7-dien-3 beta-ol (7-dehydrocholesterol), 5 alpha-cholesta-6,8(9)-dien-3 beta-ol (isodehydrocholesterol), and tentatively as cholesta-5,8(9)-dien-3 beta-ol. There was a strong positive correlation between plasma levels of the two former compounds, isodehydrocholesterol levels usually being about 1.4 times higher than those of 7-dehydrocholesterol. The median concentration of 7-dehydrocholesterol in plasma from healthy subjects was 52 ng/ml. Similar concentrations were found in colectomized patients (median concentration 47 ng/ml) and patients with extrahepatic cholestasis and alcoholic liver cirrhosis (median concentrations 79 and 67 ng/ml, respectively). Patients with ileal resection or under treatment with cholestyramine had elevated levels (median concentrations 142 and 160 ng/ml, respectively) whereas patients with primary biliary cirrhosis had subnormal levels (median concentration 26 ng/ml). The results are consistent with a positive correlation between levels of the dehydrocholesterols in plasma and the rate of cholesterol synthesis. The sterols were also analyzed in human skin and bile and the results indicate that the liver may be an important source of isodehydrocholesterol.
Virus–Complement Interactions: An Assiduous Struggle for Dominance (2010)

The complement system is a major component of the innate immune system that recognizes invading pathogens and eliminates them by means of an array of effector mechanisms, in addition to using direct lytic destruction. Viruses, in spite of their small size and simple composition, are also deftly recognized and neutralized by the complement system. In turn, as a result of years of coevolution with the host, viruses have developed multiple mechanisms to evade the host complement. These complex interactions between the complement system and viruses have been an area of focus for over three decades. In this article, we provide a broad overview of the field using key examples and up-to-date information on the complement-evasion strategies of viruses.
Blood Pressure Measurement (2019)

A blood pressure measurement system can provide different measurements types, either absolute discrete values such as systolic and diastolic pressure or continuous monitoring pulse pressure waveform. The apparatus and methods for examining blood pressure over the human body's arterial system is done, whether through an invasive or non-invasive approach. An invasive test requires the use of a hypodermic needle to puncture the skin and penetrate the artery to continuous monitor the blood pressure. The other type of examination, the non-invasive, supports a system placed on the surface of an underlying artery of a patient to collect the fluctuations in blood pressure. Many devices and methods have been developed over the years to accomplish high accuracy and continuous monitoring. A device under development for screening purposes of cardiac problems, through the identification of the pulse pressure waveform with a force sensor is described and initial results presented.
Induction of hypersensitivity to endotoxin and tumor necrosis factor by sublethal infection with Salmonella typhimurium (1990)

The effect of sublethal infection with Salmonella typhimurium on the sensitivity of mice to the lethal activity of lipopolysaccharide (LPS) was studied in C3H/TifF mice. These mice are more resistant to S. typhimurium infection and survive inocula that are lethal for most other strains of mice. Infection of C3H/TifF mice with 2 x 10(4) CFU of S. typhimurium was without lethal effect. However, administration of LPS at different times after infection revealed that the sensitivity of the animals to the lethal activity of LPS increased exponentially, reaching a maximum by 6 to 8 days after infection. Thereafter, it decreased, reaching preinfection values about 4 weeks after inoculation. At the height of sensitivity, the animals were susceptible to less than 1 microgram of LPS compared with 100 or 200 micrograms in noninfected mice. The sensitization to LPS by infection was paralleled by a sensitization to tumor necrosis factor. The time course of development of sensitization to tumor necrosis factor, as well as the time course of its decrease and disappearance, was almost identical to that of LPS.
Real-time simulation and hardware-in-the-loop tests of a battery system (2015)

In this paper, a real time model of the microgrid with an energy storage system has been implemented in RT-Lab. Coordinated control of the battery storage system with a PV system is simulated. To be more realistic, hardware-in-the-loop (HIL) testbed has been implemented with a real battery cell (3.2-V, 40-Ahr) connected to the real-time simulation model of the microgrid. A programmable current source (Magna) and programmable load (Bk 8500) have been used to create charging and discharging paths between the energy storage unit and the RT-LAB.
A Discriminative Event Based Model for Alzheimer's Disease Progression\n Modeling (2017)

The event-based model (EBM) for data-driven disease progression modeling\nestimates the sequence in which biomarkers for a disease become abnormal. This\nhelps in understanding the dynamics of disease progression and facilitates\nearly diagnosis by staging patients on a disease progression timeline. Existing\nEBM methods are all generative in nature. In this work we propose a novel\ndiscriminative approach to EBM, which is shown to be more accurate as well as\ncomputationally more efficient than existing state-of-the art EBM methods. The\nmethod first estimates for each subject an approximate ordering of events, by\nranking the posterior probabilities of individual biomarkers being abnormal.\nSubsequently, the central ordering over all subjects is estimated by fitting a\ngeneralized Mallows model to these approximate subject-specific orderings based\non a novel probabilistic Kendall's Tau distance. To evaluate the accuracy, we\nperformed extensive experiments on synthetic data simulating the progression of\nAlzheimer's disease. Subsequently, the method was applied to the Alzheimer's\nDisease Neuroimaging Initiative (ADNI) data to estimate the central event\nordering in the dataset. The experiments benchmark the accuracy of the new\nmodel under various conditions and compare it with existing state-of-the-art\nEBM methods. The results indicate that discriminative EBM could be a simple and\nelegant approach to disease progression modeling.\n
Circulating Clonotypic B Cells in the Biology of Multiple Myeloma: Speculations on the Origin of Myeloma (1996)

The population of circulating B cells in myeloma patients includes an apparently large but variable subset with the IgH VDJ rearrangement diagnostic for the malignant clone of plasma cells in individual myeloma patients. Although the biological significance is at present unknown, it is likely that they include both malignant and non-malignant clonal relatives of the myeloma plasma cells. This article presents speculations on the significance of these cells in the origin of myeloma and the relationship between monoclonal gammopathy of undetermined significance (MGUS) and frank myeloma. MGUS appears to represent the establishment of clonal dominance probably by a chronically antigen-stimulated B cell clone. It seems likely that malignant transformation event(s) occurring in a clonal daughter cell give rise to myeloma. If correct, this implies that in a myeloma patient, non-malignant antigen-responsive B cells expressing the patient-specific IgH rearrangement coexist in the circulation and probably all lymphoid tissues, with their malignant antigen-independent relatives. However, the significance one attributes to the clonotypic B cells detected in the blood of myeloma patients depends in part on the view one takes of the progression from MGUS to myeloma. An alternative perspective is that MGUS represents a dormant state of malignancy held in check by controlled apoptosis, arrested cell cycling, and/or by immunoregulatory networks. Although lacking in experimental support, if this interpretation were correct, myeloma would occur when the regulatory mechanisms fail, allowing uncontrolled malignant cell renewal. This alternative view would imply that the majority of circulating clonotypic B cells might be malignant. Thus, an analysis of the biology of these clonotypic circulating B cells, with an emphasis on measures of malignancy, is likely to shed considerable light on the events underlying myeloma genesis, progression and spread.