gebhart/patrepeval huggingface dataset:
Towards Blind Detection of Robust Watermarks in Polygonal Models (2000)

We describe a Digital Watermarking system dedicated for embedding watermarks into 3D polygonal models. The system consists of three watermarking algorithms, one named Vertex Flood Algorithm (VFA) suitable for embedding fragile public readable watermarks with high capacity and offering a way of model authentication, one realizing affine invariant watermarks, named Affine Invariant Embedding (AIE) and a third one, named Normal Bin Encoding (NBE) algorithm, realizing watermarks with robustness against more complex operations, most noticeably polygon reduction. The watermarks generated by these algorithms are stackable. We shortly discuss the implementation of the system, which is realized as a 3D Studio MAX plugin.
Narrow-bandwidth receiver (1979)

Synchronous switching circuit reduces bandwidth and improves sensitivity of communications receiver. With modified receiver, signals 35 db below level can be detected.
A 24-GHz Modular Transmit Phased Array (2011)

This paper presents a 24-GHz modular transmit phased array based on the extended-resonance technique. The extended-resonance technique, capable of obviating the need for separate power divider and phase shifters, is utilized along with heterodyne mixing in the proposed phased array. Heterodyne mixing allows phase shifting to be performed at lower frequencies. A modular approach is exploited to realize a scalable phased-array design. The design complexity associated with large phased arrays can be significantly reduced by using this approach. Moreover, a modified extended-resonance circuit topology to enhance the scan range is proposed. As a proof-of-principle, the 24-GHz transmit phased array is fabricated and the measurement results are presented.
PERSPECTIVE: TRANSPOSABLE ELEMENTS, PARASITIC DNA, AND GENOME EVOLUTION (2001)

The nature of the role played by mobile elements in host genome evolution is reassessed considering numerous recent developments in many areas of biology. It is argued that easy popular appellations such as "selfish DNA" and "junk DNA" may be either inaccurate or misleading and that a more enlightened view of the transposable element-host relationship encompasses a continuum from extreme parasitism to mutualism. Transposable elements are potent, broad spectrum, endogenous mutators that are subject to the influence of chance as well as selection at several levels of biological organization. Of particular interest are transposable element traits that early evolve neutrally at the host level but at a later stage of evolution are co-opted for new host functions.
Power-to-Gas System Valuation. Final Report (2020)

To provide a framework for evaluating the technical and financial benefits of a power-to-gas (P2G) system deployed in the Holyoke Gas and Electric (HG&E) system, Pacific Northwest National Laboratory modified its energy storage valuation tools to run a one-year simulation of P2G operations. The simulation was used to evaluate the benefits of P2G for multiple grid and industrial applications over the economic life of the unit, or units, depending on the asset configuration.
Genome-wide reconstructions of the evolution of genes and regulatory elements in ascomycota fungi (2008)

The recent availability of fully sequenced genomes from multiple related organisms has allowed researchers to investigate many long-standing questions in biology using the emerging paradigm of comparative genomics. These include: how phenotypic novelty arises through sequence divergence, how genome organization is restructured in drastic and subtle ways, and how the rich repertoire of interactions that constitute gene regulatory networks exhibit tremendous plasticity. 
Comparative genomics relies heavily on determining the corresponding features between organisms. An accurate and comprehensive cross-species mapping is essential for extracting meaningful insights by comparing genome sequences. For example, tracing the exact evolutionary history of each gene in a panel of species allows us investigate the consequences of gene duplication and loss events; two key sources of phenotypic innovation. 
In this thesis, we propose computational methods for advancing these biological questions. First, we introduce a new framework for identifying orthologous genes across a phylogeny, capturing exactly when genes were duplicated and lost. This general framework integrates various sources of evidence into a robust and scalable approach for recovering accurate gene histories from the genome annotations of extant species. We apply this framework across a panel of sequenced Ascomycota fungi genomes, allowing us to pursue new insights into the evolutionary signatures of gene duplication and loss in these species. We determine the functional principles that govern these processes, and how the forces of selection can operate distinctly between genes with different functional roles and between duplication events of different scales. Lastly, we extend this framework towards tracing the evolution of cis-regulatory elements. After building comprehensive species-specific motif catalogs, we map the corresponding elements between genomes, allowing us to glimpse into how transcription factor binding sites can be reshaped across evolution. 
These studies thoroughly embrace the potential of comparative genomics. Sequencing and annotating genomes were the initial steps towards harnessing evolution to garner new discoveries about cellular behavior. Our precise mapping of shared ancestral relations between the components of each genome realizes this promise of comparative genomics. We study how the resulting catalog of gene phylogenies can reveal meaningful insights into the evolutionary constraints that govern them. In addition, by generating an encyclopedic library of functional cis-elements, we establish the foundations for future studies of regulatory network evolution.
Peptides for disruption of PKA anchoring (2006)

Adaptor or scaffolding proteins are at the basis of multiprotein complexes that spatially and temporally co-ordinate the propagation and integration of a broad range of cellular events. One class of scaffolding proteins are AKAPs (A-kinase-anchoring proteins). They sequester PKA (protein kinase A) and other signalling molecules including phosphodiesterases, other protein kinases and protein phosphatases to specific subcellular compartments. AKAP-dependent protein-protein interactions play a role in many physiologically relevant processes. For example, AKAP-PKA interactions are essential for the vasopressin-mediated water re-absorption in renal collecting duct principal cells or beta-adrenoceptor-induced increases in cardiac myocyte contractility. Here, we discuss recently developed peptide disruptors of AKAP-PKA interactions. Such peptides are valuable tools to study the relevance of PKA anchoring in cellular processes.
Strategies of neutralization of the direct oral anticoagulants effect: review of the literature (2019)

Many neutralizing agents of anticoagulant effect of factor Xa or thrombin inhibitors (xabans and dabigatran, respectively) have been developed since the commercialization of direct oral anticoagulants (DOAC) in 2008. Idarucizumab is a specific antidote of dabigatran commercialised since 2016. An antidote of xabans, andexanet-α, was very recently approved by the Food and Drug Administration (FDA). Other antidotes of DOAC are under pre-clinical or clinical development; the most advanced being the aripazine in addition to γ-thrombine S195A and GDFXa-α<sub>2</sub>M complex. Prothrombin complex concentrates activated or not, are part of the pro-hemostatic agents suggested for DOAC handling in case of haemorrhage or preceeding urgent surgery or invasive procedures. Other pro-hemostatic agents (FXa<sup>I16L</sup>, FX (a)-C, <sup>super</sup>FVa) are in pre-clinical stage. The efficacy of these different agents in DOAC reversal and mortality reduction is still controversal in the light of the sparse results of in vitro, ex vivo, pre-clinical and clinical studies.
The UDP-sugar-sensing P2Y<sub>14</sub> receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils (2012)

The G i -coupled P2Y 14 receptor (P2Y 14 -R) is potently activated by UDP-sugars and UDP. Although P2Y 14 -R mRNA is prominently expressed in circulating neutrophils, the signaling pathways and functional responses associated with this receptor are undefined. In this study, we illustrate that incubation of isolated human neutrophils with UDP-glucose resulted in cytoskeleton rearrangement, change of cell shape, and enhanced cell migration. We also demonstrate that UDP-glucose promotes rapid, robust, and concentration-dependent activation of RhoA in these cells. Ecto-nucleotidases expressed on neutrophils rapidly hydrolyzed extracellular ATP, but incubation with UDP-glucose for up to 1 h resulted in negligible metabolism of the nucleotide-sugar. HL60 human promyelocytic leukemia cells do not express the P2Y 14 -R, but neutrophil differentiation of HL60 cells with DMSO resulted in markedly enhanced P2Y 14 -R expression. Accordingly, UDP-glucose, UDP-galactose, and UDP- N-acetylglucosamine promoted Rho activation in differentiated but not in undifferentiated HL60 cells. Stable expression of recombinant human P2Y 14 -R conferred UDP-sugar-promoted responses to undifferentiated HL60 cells. UDP-glucose-promoted RhoA activation also was accompanied by enhanced cell migration in differentiated HL60 cells, and these responses were blocked by Rho kinase inhibitors. These results support the notion that UDP-glucose is a stable and potent proinflammatory mediator that promotes P2Y 14 -R-mediated neutrophil motility via Rho/Rho kinase activation.
Peroxisome Proliferator–Activated Receptor‐α Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia (2012)

Background Data conflict with regard to whether peroxisome proliferator–activated receptor‐α agonism suppresses inflammation in humans. We hypothesized that in healthy adults peroxisome proliferator–activated receptor‐α agonism with fenofibrate would blunt the induced immune responses to endotoxin (lipopolysaccharide [ LPS ]), an in vivo model for the study of cardiometabolic inflammation. Methods and Results In the Fenofibrate and omega‐3 Fatty Acid Modulation of Endotoxemia (FFAME) trial, 36 healthy volunteers (mean age 26±7 years, mean body mass index 24±3 kg/m 2 , 44% female, 72% white) were randomized to fenofibrate 145 mg or placebo daily. After 6 to 8 weeks of treatment, subjects underwent a low‐dose LPS challenge. Clinical and blood measurements were collected at randomization, before LPS administration, and serially for 24 hours after LPS administration. We examined area under the curve for evoked responses by treatment group. Compared to placebo, but before LPS challenge, fenofibrate reduced total cholesterol and tended to decrease triglycerides, consistent with achieved therapeutic plasma levels of fenofibric acid. In the placebo group, LPS induced a modest inflammatory response with increased cytokines and chemokines (2‐ to 4‐hour post‐ LPS 8‐fold increase in tumor necrosis factor‐α, 9‐fold increase in interleukin‐6, 9‐fold increase in interleukin‐10, and 10‐fold increase in monocyte chemotactic protein‐1; all P <0.001) and acute‐phase reactants (24‐hour post‐ LPS 15‐fold increase in serum amyloid A and 9‐fold increase in C‐reactive protein; both P <0.001). Compared to placebo, however, fenofibrate did not significantly attenuate LPS ‐induced levels of plasma cytokines, chemokines, or acute‐phase proteins. Conclusions These data suggest a lack of systemic antiinflammatory properties of fenofibrate at clinically relevant dosing in humans. Clinical Trial Registration URL: http://clinicaltrials.gov/ct2/show/NCT01048502 . Unique identifier: NCT01048502.
1,2-Phenylene-bridged diporphyrin linked with porphyrin monomer and pyromellitimide as a model for a photosynthetic reaction center: synthesis and photoinduced charge separation (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,2-Phenylene-bridged diporphyrin linked with porphyrin monomer and pyromellitimide as a model for a photosynthetic reaction center: synthesis and photoinduced charge separationAtsuhiro Osuka, Satoshi Nakajima, Kazuhiro Maruyama, Noboru Mataga, Tsuyoshi Asahi, Iwao Yamazaki, Yoshinobu Nishimura, Takeshi Ohno, and Koichi NozakiCite this: J. Am. Chem. Soc. 1993, 115, 11, 4577–4589Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ja00064a021https://doi.org/10.1021/ja00064a021research-articleACS PublicationsRequest reuse permissionsArticle Views459Altmetric-Citations127LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structures and Reactions of the Oxidation Products of Dimeric Ketenylidene(triphenyl)phosphorane (1993)

The neutral cyclobutanetrione 2 is synthesized from dimeric ketenylidene(triphenyl)phosphorane 1 by treatment with two equivalents of N-p-tolylsulfonyl(phenyl)oxaziridine. Oxidation of 1 with one equivalent of the oxaziridine provides compound 3, which like 2 was characterized by X-ray structure analysis. Compound 3 functions as a dienophile in Diels–Alder reactions.
Exploring Prefetching, Pre-Execution and Branch Outcome Streaming for In-Memory Database Lookups (2019)

Lookup operations for in-memory databases are heavily memory-bound because they often rely on pointer-chasing linked data structure traversals. They are also branch heavy with branches that are hard-to-predict due to random key lookups. In this study, we show that although cache misses are the primary bottleneck for these applications, without a method for eliminating the branch mispredictions, only a small fraction of the performance benefit is achieved through prefetching. We propose the Node Tracker (NT), a novel programmable prefetcher/pre-execution unit that is highly effective in exploiting inter key-lookup parallelism to improve single-thread performance. We extend the NT with branch outcome streaming (BOS) to reduce branch mispredictions and show that NT with BOS can achieve an extra 3x speedup. Finally, we evaluated the NT as a pre-execution unit and show that we can further improve the performance in both single- and multi-threaded execution modes.
ChemInform Abstract: BENZO(B)BIPHENYLEN AUS BIPHENYLEN‐DERIVATEN DURCH ELEKTROCYCLISCHEN RINGSCHLUSS (1975)

Abstract Biphenylen‐2‐acetonitril (I) kondensiert sich mit den Diazapentadieniumperchloraten (II) in Chinolin in Gegenwart von Natriummethylat bei 50‐70°C zu den Verbindungen (III), die bei Temperaturen von 145 ‐ 205°C zu den Benzo(b)biphenylenen (IV) cyclisieren.
An Overview of Physiologic Immunity (2014)

An understanding of one's response to a transplanted organ requires a fundamental understanding of the immune system in general, and its function in the context of physiological homeostasis. The immune system comprises a complex system of tissues, cells, and soluble (humoral) factors that constitute the body's multilayered defenses against disease. It is capable of detecting a wide variety of foreign agents and stages of cellular distress and of distinguishing them from the body's own healthy tissues. Multiple mechanisms mediate the recognition and neutralization of pathogens/foreign material. Evolutionary ancient, non-specific, innate/immediate basic defense mechanisms, such as phagocytosis (mediated by neutrophils, macrophages, and dendritic cells), antimicrobial peptides, and the complement system of proteins, co-exist with more evolutionarily recent elements mediating adaptive or acquired immunity. Adaptive immunity is a property of lymphocytes and, unlike the innate immune system, confers specificity and immunological memory. T lymphocytes mediate and regulate cellular immunity, whereas B cells are involved in production of antibody. The functions of these and other cells involved in host defense are regulated by peptides termed cytokines that are generated in response to challenges to host integrity. Important mechanisms also exist within the immune system to prevent inappropriate attack against self and to maintain self-tolerance.
An Echelle Spectrograph for Image Tubes (1972)

An Echelle spectrograph specially developed for image tubes is presented. A Czerny-Turner mount is used and the optimization of the optics in respect to aberrations, order sorters and the focal surface is discussed. The image tube used is an image dissector tube with a photocathode 20 mm in diameter. The wavelength range covered is 1 700-4 000 Å.
Effects of the Nail Geometry and Humidity on the Nail Penetration of High-Energy Density Lithium Ion Batteries (2021)

Internal short-circuit tests were carried out in a battery safety investigation chamber to determine the behavior of batteries during the nail penetration test. So far, systematic investigations regarding the test setup and its influence are rarely found in the literature. Especially, to improve the comparability of the multitude of available results, it is essential to understand the effects of the geometric, operating and ambient parameters. In this study commercial lithium ion batteries with a capacity of 5.3 and 3.3 Ah were used to study the influence of the varied parameters on the voltage drop, the development of surface temperatures and of infrared active gas species. We studied both the influence of the geometry of the penetrating nail and concentration of water in the inert atmosphere especially on the quantities of the reaction products under variation of cell capacity. It could be shown that the geometry of the nail, within certain limits, has no influence on the processes of the thermal runaway of high energy density lithium ion batteries (LIBs). However, a change in capacity from 5.3 to 3.3 Ah shows that in particular the gaseous reaction products differ: The standardized gas concentrations show a higher measurable concentration of all gases except CO for the 3.3 Ah LIBs. This circumstance can be explained by the intensity of the reactions due to the different battery capacities: In the 5.3 Ah cells a larger amount of unreacted material is immediately discharged from the reaction center, and by the different available amounts of oxidizing reaction partners. An increase of the water content in the surrounding atmosphere during the thermal runaway leads to a reduction of the measurable gas concentrations of up to 36.01%. In general, all measured concentrations decrease. With increased water content more reaction products from the atmosphere can be directly bound or settle as condensate on surfaces.
Mast cells enable heightened humoral immunity during infection (B178) (2007)

Abstract Dendritic cell (DC) accumulation in T-cell zones of secondary lymph organs is a critical event in the maximization of the primary immune response. Here, we demonstrate that mast cell (MC) control of elevated DC trafficking during infection enables the primary adaptive humoral immune response to proceed with heightened intensity. Elevated DC accumulation in draining lymph nodes (DLNs) was found to be the product of continual and incremental recruitment of DCs into the infected tissue site prior to their egress to DLNs. MCs contribute to this pattern of DC trafficking by the release of TNF, which was found to coordinately activate local blood vessel endothelium and DLNs to increase their expression of CD62E and CCL21, respectively. Blockade of either protein interfered with DC accumulation in DLNs, as well as the intensity of the humoral response to bacterial challenge. Thus, MCs enable the humoral immune response to proceed with enhanced intensity, which may be an important consideration in rationale vaccine design. Supported by grants DK50814 and AI50021 from the National Institutes of Health.
Optimal Plaster Conformation Derived Using a Custom-Made Jig to Obtain Maximum Strength of Protective Plaster of Paris for Hand Surgery (2007)

Backslabs can be strengthened significantly by placement of a single reinforcing ridge. This allows plaster weight and thickness to be kept to a minimum, reducing the setting time of the plaster and contributing to patient comfort. These findings demonstrate the ideal construction of angled plaster of Paris backslabs for the protection of soft tissue repairs.