gebhart/patrepeval huggingface dataset:
MENTHO, a MLN64 Homologue Devoid of the START Domain (2002)

MLN64 is a late endosomal membrane protein containing a carboxyl-terminal cholesterol binding START domain and is presumably involved in intracellular cholesterol transport. In the present study, we have cloned a human cDNA encoding a novel protein that we called MENTHO as an acronym for MLN64 N-terminal domain homologue because this protein is closely related to the amino-terminal half of MLN64. MLN64 and MENTHO share 70% identity and 83% similarity in an original protein domain encompassing 171 amino acids that we designated as the MENTAL (MLN64 N-terminal) domain. By translation initiation scanning MENTHO is synthesized as two isoforms of 234 (alpha) and 227 (beta) amino acids that can be phosphorylated. As MLN64, MENTHO is ubiquitously expressed and is located in the membrane of late endosomes, its amino and carboxyl-terminal extremities projecting toward the cytoplasm. We show that MENTHO overexpression does not rescue the Niemann-Pick type C lipid storage phenotype. However, MENTHO overexpression alters severely the endocytic compartment by leading at steady state to the accumulation of enlarged endosomes. These results indicate that in addition to its previously established function in addressing and anchoring proteins to the membrane of late endosomes, the MENTAL domain possesses an intrinsic biological function in endocytic transport.
Diagnostic performance of computed tomographic coronary angiography in patients with end-stage renal disease (2012)

Results show 64-row multidetector CCTA is highly sensitive and specific in the detection of coronary artery stenosis irrespective of ESRD. Our findings suggest that CCTA is a promising diagnostic tool for the timely detection and/or exclusion of coronary atherosclerosis in patients undergoing pretransplant cardiovascular surveillance.
Cannabinoid pharmacotherapy: past, present and future. (2006)

Cannabinoids are medically interesting, but the available data are still weak scientifically and overwhelming anecdotally. In the management of pain, cannabinoids have been shown to have antinociceptive properties in animal models of pain, with non-opiate mechanisms appearing to predominate. A widely cited meta-analysis suggested that cannabinoids offer moderate pain relief, similar to codeine, and limited by side effects. Further research, particularly into modes of delivery, to assess their therapeutic potential are needed. Any successful future clinical development of cannabinoid pharmacotherapy depends upon a dosage form that is reliable, rapidly titratable to effect, non-smoked, and preferably parenteral to avoid hepatic first pass metabolism.
A method for robust and quick video searching using probabilistic dither-voting (2002)

We propose a quick and accurate search method for detecting a query signal from long video recordings The method is based on the time-series active search, which is a quick searching method for audio and video signals that we previously proposed. Time-series active search is based on a histogram matching scheme and an efficient pruning mechanism, and therefore, it was very quick. We found, however, that the accuracy sometimes deteriorates when it is applied to searches through long video archives that are composed of many similar video images or those containing feature distortions caused by video dubbing or low-bit-rate compression. The problem arises from (1) insufficient capability of representing features and (2) feature distortions. Thus, the method proposed here uses LBG-based VQ to improve the capacity to represent features and probabilistic dither-voting to improve robustness with respect to feature distortions. The experiments prove the effects of the proposed method.
The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans (2011)

IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis. We investigated the immunological consequences of the protective IL23R R381Q gene variant in healthy donors. The IL23R R381Q gene variant had no major effect on Th17 cell differentiation as the frequency of circulating Th17 cells was similar in carriers of the IL23R protective (A) and common (G) allele. Accordingly, Th17 cells generated from A and G donors produced similar amounts of Th17 cytokines. However, IL-23-mediated Th17 cell effector function was impaired, as Th17 cells from A allele carriers had significantly reduced IL-23-induced IL-17A production and STAT3 phosphorylation compared to G allele carriers. Our functional analysis of a human disease-associated gene variant demonstrates that IL23R R381Q exerts its protective effects through selective attenuation of IL-23-induced Th17 cell effector function without interfering with Th17 differentiation, and highlights its importance in the protection against IL-23-induced tissue pathologies.
Influence of Crystallite Size on the Magnetic Properties of Acicular γ-Fe2O3 Particles (1968)

Magnetic properties have been measured for a number of samples of acicular γ-Fe2O3 particles of the type used in magnetic recording tapes. The average particle size and shape were approximately the same for all samples. However, the average crystallite sizes of the samples, as determined from x-ray line broadening, ranged from 50 to 700 Å. All magnetic properties measured showed a strong dependence on average crystallite size. Saturation magnetization at room temperature, σ, decreased sharply with decreasing crystallite size. An excellent fit to the σ vs crystallite size data was made by assuming that the crystallites were separated by a nonmagnetic grain boundary on the order of 6 Å wide. Room-temperature coercive force decreased with decreasing crystallite size, and the ratio Hc(83°K)/Hc(293°K) increased sharply with decreasing crystallite size. The data support a particle model in which the constituent crystallites interact magnetostatically across nonmagnetic grain boundaries. A critical crystallite diameter of order 400 Å may be inferred. Below this crystallite size, superparamagnetic behavior is observed; above this size, noncoherent magnetization reversals in the crystallites are suggested. This model is quite consistent with the ``fanning'' mode of reversal based on a ``chain-of-spheres'' model which has been considered by several authors to be most compatible with their data on γ-Fe2O3 particle assemblies.
Gender-specific velocity recognition of caress-like stimuli through nonlinear analysis of Heart Rate Variability (2015)

This study reports on the development of a gender-specific classification system able to discern between two levels of velocity of a caress-like stimulus, through information gathered from Autonomic Nervous System (ANS) linear and nonlinear dynamics. Specifically, caress-like stimuli were administered to 32 healthy volunteers (16 males) while monitoring electrocardiogram signal to extract Heart Rate Variability (HRV) series. Caressing stimuli were administered to the forearm at a fixed force level (6 N) and two levels of velocity, 9.4 mm/s and 37 mm/s. Standard HRV measures, defined in the time and frequency domain, as well as HRV nonlinear measures were extracted during the pre- and post-stimulus sessions, and given as an input to a Support Vector Machine (SVM) classifier implementing a leave-one-subject-out procedure. Results show an accuracy of velocity recognition of 70% for the men, and 84.38% for the women, when both standard and nonlinear HRV measures were taken into account. Conversely, non-significant results were achieved considering standard measures only, or a gender-aspecific classification. We can conclude that caress-like stimuli elicitation significantly affect HRV nonlinear dynamics with a highly specific gender dependency.
Conditional sampling of velocity in a turbulent nonpremixed propane jet (1987)

Mesure des vitesses axiale et radiale simultanees dans un jet de propane non reactif aux grands nombres de Reynolds
Selenomethionine as a Safer Substitute for Barium Selenate in Long-Acting Injectable Se Supplements for Food-Producing Animals (2017)

Nutritional supplementation with selenium (Se) can prevent Se deficiency in food-producing animals. Injection with slow-release formulations is a preferred method for free-range grazing sheep and cattle, and barium selenate (BaSeO<sub>4</sub>) provides optimal efficacy. This chemical can become a health risk to humans if the concentrated depot of an injection site is consumed, and consequently such use is recently banned in the EU. A possible replacement is selenomethionine (SeMet), a naturally occurring form of Se supplementation hitherto only administered orally. In four animal studies we found that injection with SeMet maintained nutritionally adequate concentrations of Se in blood and tissues of lambs for at least 191 days and in blood and milk of dairy cows for at least 95 days. Stereoisomer forms L- and DL-SeMet were functionally equivalent. This is the first demonstration that injectable SeMet can deliver efficacy similar to BaSeO<sub>4</sub> but with less risk of undesirable residues in edible tissues.
High Bandwidth Powered Resonance Tube Actuators with Feedback Control (2002)

High bandwidth actuators are required if Active Flow Control (AFC) is to be used at various locations on an aircraft and over a range of flight speeds. The actuator selected for bandwidth enhancement was the Powered Resonance Tube (PRT) that is an adaptation of the Hartmann Whistle. The actuator consists of a high speed jet aimed at the open end of a cylindrical resonance tube closed at the other end by an air tight piston. The depth of the resonance tube determines the hquency of the signal produced by the actuator. The high bandwidth capability of this device was previously demonstrated by Raman et al. (2002) by using a computer controlled open loop Look Up Table @UT) approach to change the depth of the resonance tube. The LUT approach was prone to errors under certain conditions. The present work overcomes difficulties associated with the LUT approach by using closed loop control using both Single Input Single Output (SISO) and Multi Input Multi Output (MIMO) control. The parameter changed in the SISO approach was the depth of the resonance tube, whereas the MlMO approach changed both the depth and the spacing between the supply jet and the resonance tube. The “spacing’ served as a tuning parameter that ensured that the resonance tube actuator produced high levels of pressure perturbation at all fkequencies. For both methods, using the LUT result as an initial estimator produced better results that using the Q y t e r Wavelength Theory (QW).
Assessment of the genotoxic potential of ISIS 2302: a phosphorothioate oligodeoxynucleotide (2002)

ISIS 2302, a phosphorothioate oligodeoxynucleotide with antisense activity against human ICAM-1 mRNA, was evaluated in a battery of tests to assess genotoxic potential. There was no evidence of genotoxicity in three in vitro studies performed: (i) a bacterial reverse mutation test; (ii) a chromosomal aberration test in Chinese hamster ovary cells; (iii) a mammalian cell gene mutation assay in L5187Y cells. Additionally, there was no in vivo evidence of genetic toxicity in a bone marrow micronucleus study in male and female mice. For all tests, top concentrations or doses assessed met harmonized regulatory guidelines. The cellular uptake of ISIS 2302 into target cells was confirmed using capillary gel electrophoresis and immunohistochemistry. Intracellular uptake into CHO cells, L5187Y cells, Salmonella typhimurium TA98 and bone marrow was concentration- and time-dependent. Consistent with what is known about the physical and chemical properties of phosphorothioate oligodeoxynucleotides, there was no evidence of genotoxicity in any of the assessed end-points. Furthermore, the absence of genotoxicity could not be ascribed to test system insensitivity or to an absence of exposure of the test system to ISIS 2302.
Rynki azjatyckie jako kierunki ekspansji eksportowej polskich przedsiębiorstw (2015)

W artykule podjeto problematyke atrakcyjności krajow Azji jako potencjalnych rynkow zbytu dla polskich produktow. Autor zwrocil uwage na dynamiczny rozwoj gospodarczy tego regionu, scharakteryzowal polską obecnośc na tamtejszych rynkach oraz ocenil perspektywy jej rozwoju.
Clinical frailty scale and outcome after coronary artery bypass grafting (2018)

NCT02319083.
Environmental Effects of Mining Industries in Meymeh Region, North West of Isfahan (2013)

Meymeh industrial civil has been located in the vicinity of Isfahan city (100 km of NW) and along the road of Isfahan- Tehran. Meymeh industrial unit built from various stone cutting that provide its required stone from quarries around the Meymeh and Isfahan. Increasing mining activities are one of the most important economic activities in Meymeh region. These activities will cause environmental problems. Due to a variety of different activities and also the difference in the output wastes in this type of civil, purification process to remove various pollutants are not fully. Industrial output after a brief treatment, directly is poured into the soil or ground waters. We present 10 methods that result in mining progress and have the least damages to environment.
Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns. (1990)

Sex-specific alternative RNA splicing of the doublesex (dsx) pre-mRNA results in sex-specific polypeptides that regulate both male and female somatic sexual differentiation in Drosophila melanogaster. We have molecularly characterized a class of dsx mutations that act in cis to disrupt the regulation of dsx RNA processing, causing the dsx pre-mRNA to be spliced in the male-specific pattern regardless of the chromosomal sex of the fly. These dsx mutations are associated with rearrangements in the female-specific exon just 3' to the female-specific splice acceptor. The mutations do not affect the female-specific splice sites or intron that are identical to wild-type sequences. These results indicate that sequences in the female-specific exon are important for the regulation of sex-specific RNA splicing, perhaps by acting as sites of interaction with trans-acting regulators. Furthermore, the data suggest that female-specific regulation of dsx RNA processing occurs by promoting the usage of the female splice acceptor site, rather than by repressing the usage of the alternative male-specific splice acceptor.
Proton-Induced Reversible Modulation of the Luminescent Output of Rhenium(I), Iridium(III), and Ruthenium(II) Tetrazolate Complexes (2013)

One of the distinct features of metal-tetrazolate complexes is the possibility of performing electrophilic additions onto the imine-type nitrogens of the coordinated five-membered ring. These reactions, in particular, provide a useful tool for varying the main structural and electronic properties of the starting tetrazolate complexes. In this paper, we demonstrate how the use of a simple protonation-deprotonation protocol enables us to reversibly change, to a significant extent, the light-emission output and performance of a series of Re(I)-tetrazolate-based phosphors of the general formulation fac-[Re(N(∧)N)(CO)3L], where N(∧)N denotes diimine-type ligands such as 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) and L represents a series of different 5-aryl tetrazolates. Indeed, upon addition of triflic acid to these neutral Re(I) complexes, a consistent blue shift (Δλmax ca. 50 nm) of the emission maximum is observed and the protonated species also display increased quantum yield values (4-13 times greater than the starting compounds) and longer decay lifetimes. This alteration can be reversed to the initial condition by further treating the protonated Re(I) complex with a base such as triethylamine. Interestingly, the reversible modulation of luminescent features by the same protonation-deprotonation mechanism appears as a quite general characteristic of photoactive metal tetrazolate complexes, even for compounds in which the 2-pyridyl tetrazolate ligands coordinate the metal center with a bidentate mode, such as the corresponding Ir(III) cyclometalates [Ir(C(∧)N)2L] and the Ru(II) polypyridyl derivatives [Ru(bpy)2L](+). In these cases, the protonation of the starting materials leads to red-shifted and more intense emissions for the Ir(III) complexes, while almost complete quenching is observed in the case of the Ru(II) analogues.
Photovoltaic devices based on photo induced charge transfer in polythiophene: CN-PPV blends (2003)

We have investigated the photovoltaic properties of polymer devices based on a blend of two polymers, (poly(3-(2'-methoxy-5'-octylphenyl) thiophene) (POMeOPT) and poly(2,5,2',5'-tetrahexyloxy-7,8'-dicyanodi- p-phenylenevinylene) (CN-PPV), where photo induced charge transfer takes place at the interfaces formed by the interpenetrating network of the donor and the acceptor. The polymer blend films resulting from the spin coating were phase separated and the photo response of the devices depended on the morphology of the segregation. We have studied different blend ratios by photoluminescence quenching, scanning force microscopy and photovoltaic measurements. External quantum efficiencies of 4.5% at 500nm were achieved for the less segregated polymer blend.
O-003 Prediction of periprocedual ischemic complication in carotid artery stenting with filter embolic protection device: feasibility of MR plaque imaging (2010)

Purpose Our purpose is to investigate the feasibility of MR plaque imaging to predict the high risk lesion for ischemic complication during carotid artery stenting (CAS) using a filter embolic protection device (EPD). Methods 100 carotid artery stenotic lesions in 96 patients before CAS (89 men and seven women; median age 72.2 years) were evaluated by MR plaque imaging with black blood T1 weighted images. The population consisted of 52% symptomatic stenosis, more than 50% at the common or internal carotid artery, and 48% asymptomatic stenosis more than 80% stenosis. All CAS procedures were performed by standard procedure using filter EPD (Angioguard XP). Main plaque components were classified into unstable plaque (intraplaque hemorrhage and lipid rich/necrotic core) and stable (fibrous tissue and dense calcification) from the signal pattern. Development of new ischemic lesions on diffusion weighted imaging was assessed within 48 h after CAS. We made statistical assessment on the plaque classification and the number of new ischemic lesions. Results Technical success with the CAS procedures was achieved in 100 (100%) procedures. Ipsilateral new ischemic lesions were observed in 34 CAS procedures (34.0%). Ipsilateral multiple ischemic lesions (>10) were observed in seven CAS procedures (7%). In seven patients with multiple ischemic lesions, four showed minor strokes, two showed a transient ischemic attack and one was asymtopmatic. New ischemic lesions except multiple ischemic lesions were all asymtopmatic. There was no significant difference between unstable and stable plaques for the presence of new ischemic lesion. However, multiple ischemic lesions occurred significantly (p<0.01) more frequently in patients with unstable plaque. Conclusions Presence of unstable carotid plaques showed a higher risk of ischemic complication of CAS with filter EPD than stable plaques.
Theoretical efficiency of an all-glass tubular solar collector using a chemically deposited SnS-Cu<sub>x</sub>S absorber inside the inner tube (1992)

Theoretical efficiencies of an evacuated-tube solar collector using a chemically deposited SnS-CuxS absorber thin film ( alpha =0.91) in contact with the working fluid are presented. A mathematical model is developed and solved numerically to yield photothermal conversion efficiencies eta of the collector for the heat transfer coefficient hb of 0.026 W m-2 K-1 (good vacuum). The analysis shows that the eta of such a collector would be unacceptably low, approximately=25%, for the operating parameter f approximately=0.1 degrees C m2 W-1 which represents the typical operating condition of an evacuated-tube solar collector. However, the use of a low emissivity ( epsilon ) transparent coating applied to the outer surface of the absorber tube (i.e. in the place of the spectrally selective solar absorber coating in the conventional all-glass evacuated-tube collector) can yield eta approximately=75% for f approximately=0.1 degrees C m2 W-1 for epsilon =0.1 with water as the heat transfer fluid and eta approximately=68% with a mineral oil as the heat transfer fluid.
Computed Tomography-Estimated Specific Gravity at Hospital Admission Predicts 6-Month Outcome in Mild-to-Moderate Traumatic Brain Injury Patients Admitted to the Intensive Care Unit (2012)

Degos, Vincent*†; Lescot, Thomas*; Icke, Christian*; Le Manach, Yannick*; Fero, Katherin†; Sanchez, Paola*; Hadiji, Bassem*; Zouaoui, Abederrezak‡; Boch, Anne-Laure§; Abdennour, Laine*; Apfel, Christian C.†; Puybasset, Louis* Author Information
Withholding and Withdrawing Life-Sustaining Therapy (1991)

"Withholding and Withdrawing Life-Sustaining Therapy." American Review of Respiratory Disease, 144(3_pt_1), pp. 726–731
Cytoplasmic restoration and persistence of glucose-6-phosphate dehydrogenase activity in stable hybrid myotubes. (1993)

In previous experiments, we obtained an in vitro restoration of a cytosolic enzyme glucose-6-phosphate dehydrogenase (G6PD) in hybrid myotubes formed between G6PD-deficient and human or murine myoblasts. In the present series of experiments, the degree of restoration was observed and the persistence of the restored activity was evaluated in the hybrids formed. Quantitative measurements of enzymatic activity in single human-human or human-mouse myotubes, identified by using either fluorescent latex microspheres or Hoechst stain 33258, were made by using a computer-controlled Leitz photometer. Histospectrophotometry and statistical analysis showed a 50% restoration of enzymatic activity in human-human hybrids compared to deficient and normal myotubes. The restored activity was uniformly distributed throughout the cytoplasm and persisted in long-term cultures. No nuclear domain was observed for G6PD. Knowledge of the degree of restoration, of the extent of distribution of the products of "competent" nuclei and the demonstration that the correction is not a transitory event in vitro, supports the potential usefulness of myoblast transfer therapy for this type of myopathy.
Centrosymmetric crystals of a designed alpha-helical peptide (1996)

BIOLOGICAL SMALL MOLECULES cyclosporin complexed to the FAB fragment of an antibody.
Determination of roto-vibrational temperatures by comparison with simulated spectra (1996)

One approach developed in the last decade for the detn. of mol. roto-vibrational temps. is to compare exptl. spectra with computer simulated spectra. The aim of the present work is to study the efficiency of a new computer fit procedure based on multiple fitting parameters, for comparison between the recorded and simulated spectra. The procedure can be applied for instance when the app. profile width, the relative spectral sensitivity of the spectral system or continuous plasma emission of the spectra are lacking. [on SciFinder (R)]