gebhart/patrepeval huggingface dataset:
Abstract 2247: Platinoid-induced MHCI antigen presentation enables checkpoint inhibitor responsiveness (2019)

Abstract Many cancers are refractory to immune checkpoint therapy (ICT), but the causes of ICT resistance remain unknown. Despite low mutational burden, hepatocellular carcinoma (HCC) responds to PD-1 blockade, but prostate cancer (PCa) does not. RNA-seq analysis revealed that, unlike HCC, PCa cells poorly express MHC-I molecules and components of the MHC-I antigen processing and presentation machinery. We found that treatment of PCa cells and other tumor types with platin-based drugs, especially low dose Oxaliplatin, led to a pronounced upregulation of MHC-I molecules and their antigen generating and loading machinery. Most importantly, Oxaliplatin synergistically potentiated the effect of exogenous IFNγ; a conclusion based on two cumulative observations. First, ATAC-seq analyses revealed that Oxaliplatin activates MHC machinery through different pathways compared to well-known IFNγ signaling. Second, Oxaliplatin upregulates IFNγR2 expression in cancer cells. Induction of IFNγR2, which was needed for Oxaliplatin-potentiation of ICT-induced tumor rejection in vivo, depended on NF-κB signaling. Induction of IFNγR2, which was needed for Oxaliplatin-potentiation of ICT-induced tumor rejection in vivo, depended on NF-κB signaling. Moreover, we found that Oxaliplatin activates histone acetyltransferases (HATs) which alter chromatin structure of genes encoding MHC-I complex components, thereby enabling recruitment of a diverse array of activating transcription factors. Our data indicates that combining ICT with an appropriate low dose platinoid chemotherapeutic agent is useful in reinvigorating the immune response to tumors that have escaped immune destruction due to MHC-I downregulation and do not respond to single agent therapy. Citation Format: Ingmar Niels Bastian, Weihua Li, Qui Phung, Kathleen Fisch, Jennie Lill, Michael Karin, Shabnam Shalapour. Platinoid-induced MHCI antigen presentation enables checkpoint inhibitor responsiveness [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2247.
View volume culling using a probabilistic caching scheme (1997)

This paper a new algorithm for view volume culling. During an interactive walkthrough of a 3D scene, at any moment a large proportion of objects will be outside of the view volume. Frame-to-frame coherence implies that the sets of objects that are completely outside, completely inside, or intersecting the boundary of the view volume, will change slowly over time. This coherence is exploited to develop an algorithm that quickly identifies these three sets of objects, and partitions those completely outside into subsets which are probabilistically sampled according to their distance from the view volume. A statistical object representation scheme is used to classify objects into the various sets. The algorithm is implemented in the context of a Binary Space Partition tree, and preliminary investigation of the algorithm on two scenes with more than 11,000 polygons, suggests that it is approximately twice as fast as the hierarchical bounding box approach to culling, and that only about 14% of the total frame-polygons are passed through the viewing pipeline during the course of a walkthrough.
Exploring the web with OXPath (2011)

OXPath is a careful extension of XPath that facilitates data extraction from the deep web. It is designed to facilitate the large-scale extraction of data from sophisticated modern web interfaces with client-side scripting and asynchronous server communication. Its main characteristics are (1) a minimal extension of XPath to allow page navigation and action execution, (2) a set-theoretic formal semantics for full OXPath, (3) and a sophisticated memory management that minimizes page buffering. In this poster, we briefly review the main features of the language and discuss ongoing and future work.
Determinants of Induction of Increased Synthesis of Plasminogen Activator Inhibitor Type-1 in Human Endothelial Cells by t-PA (1992)

Tissue-type plasminogen activator (t-PA) induces synthesis of a rapidly acting inhibitor, plasminogen activator inhibitor type-1 (PAI-1) in human umbilical vein endothelial cells (HUVEC) in culture. In vivo, an analogous process may induce negative feedback on the fibrinolytic system. To define specific determinants in the t-PA molecule contributing to the induction, PAI-1 synthesis was characterized in 35S-methionine labeled HUVEC in response to several molecular variants of t-PA. Catalytically active variants devoid of several specific structural domains in the A-chain retained the capacity to form complexes with PAI-1 and to induce increased concentrations of total PAI-1 (free and complexed) in conditioned media without depleting PAI-1 from the extracellular matrix. Surprisingly, a mutant t-PA with markedly reduced catalytic activity reflecting replacement of the active site serine with threonine (S478T) formed complexes with PAI-1 and induced increased PAI-1 synthesis as well. However, in contrast to wild-type t-PA and A-chain variants, it did not release 35S-methionine labeled PAI-1 from the extracellular matrix. Thus, its effects appeared to reflect increased secretion exclusively. Our results suggest that induction of PAI-1 synthesis in HUVEC by t-PA depends on its protease domain but that an active site serine is not a requirement.
C07 A fundamental research on the base-isolation system with silicon rubber ball bearing (2005)

This is a feasibility study of a new seismic base-isolation system with compressed silicon-rubber balls for light weight structures. This paper proposes the restoring force characteristics in the horizontal direction derived by the vibration test of the structure with the rubber ball bearing system. In addition to this, the long-term durability of the bearing balls is evaluated by accelerated aging tests. The experiment shows that the restoring force characteristics can be expressed by the Harding-Drinevich model in the case without consideration of aging effect, by adding the non-linear curve model to the HD model in the case with aging effect. Furthermore, the aging tests show that the silicon rubber ball bearing has high level of durability, comparing to that of the material rubber ball bearing. And this paper shows that the analysis results have good agreements to that conducted by the shaking table test for a full-scale model.
The effect of incisional negative pressure therapy on wound complications after acetabular fracture surgery. (2010)

The purpose of the study was to determine if the use of incisional negative pressure therapy affected the rate of wound complications after acetabular fracture surgery. Between August 1996 to April 2005, 301 patients were found to have had an operatively treated acetabular fracture. There were 235 patients who had placement of incisional vacuum-assisted closure (VAC) who had three (1.27%) deep wound infections and one (0.426%) wound dehiscence. There were 66 consecutive patients who were available in the 5 years preceding the usage of the incisional VAC who had four (6.06%) deep wound infections and two (3.03%) wound dehiscences. This is less than the published infection rate of 4% for patients undergoing operative treatment of acetabular fractures and less than the authors' rate of 6.15% in the time period before the use of the incisional negative pressure wound therapy (p=.0414). The use of incisional negative pressure wound therapy significantly decreases perioperative wound complications after acetabular fracture surgery.
Effect of plasma α‐tocopherol on leukotriene E4 excretion in genetic vitamin E deficiency (1997)

Studying the biological effects of vitamin e in humans is difficult because conditions involving vitamin E deficiency are usually associated with chronic multiple pathology. Genetic vitamin E deficiency caused by a deficient alpha-tocopherol transport protein offers unique possibilities for study of vitamin E effects since the patients can be studied in good general health. In such a patient we manipulated plasma alpha-tocopherol levels in a wide range by varying oral alpha-tocopherol supplements and measured urinary leukotriene E4 (LTE4) concentrations. LTE4 excretion proved inversely correlated to plasma alpha-tocopherol levels. This strongly suggests that in genetic vitamin E deficiency, alpha-tocopherol influences formation of leukotrienes in vivo.
Efficacy of peptide receptor radionuclide therapy (PRRT) as first or second line treatment in advanced metastatic gastric NET (2012)

1215 Objectives Metastasized neuroendocrine tumors of the stomach (G-NET) are rare and no approved sytemic therapeutic options are available. The aim of this retrospective study was to assess the efficacy of peptide receptor radionuclide therapy (PRRT) as first or second line treatment option in advanced metastatic G-NET. Methods In our database we found 6 patients with metastasized and progressive G-NET who were evaluated for PRRT using Y-90 or Lu-177 DOTATATE. Five of these patients were finally treated with PRRT. Three of these patients were treated in our hospital, the other two patients outside. Response assessment (using RECIST) was performed at 3 months after the last cycle by using Ga-68 DOTATATE PET/3-Phase ceCT, MRI and esophagogastroduodenoscopy (EGD). PRRT was performed under appropriate amino acid nephroprotection. Kidney function assessment of the patients treated at our institute was performed using Tc-99m MAG3 dynamic scintigraphy. Results PRRT was performed in 1-4 cycles; dose range for Y-90 DOTATATE 2.1 - 4.6 GBq, for Lu-177 DOTATATE 5.3 -7.5 GBq. The primary tumor could be resected in one patient after completion of the PRRT. One patient received PRRT after partial gastrectomy. Overall, 4/5 patients received PRRT as first line therapy. Response assessment at 3 months after the end of PRRT showed partial remission in 2 patients, stable disease in 1 patients, and minor or partial response in two patients. PRRT successfully achieved its aim of reducing the primary tumor in size in 1patient (partial remission on EGD). One patient showed grade 3 hematotoxicity and grade 3 nephrotoxicity. The remaining 4 patients showed no appreciable PRRT related toxicity. Conclusions To the best of our knowledge this study shows for the first time that PRRT is a good first or second line treatment option in patients with advanced metastatic progressive gastric NET
The impact behavior of rigid PVC compounds (1966)

Abstract Many rigid PVC compounds show a sharp transition from tough to brittle fracture with decreasing temperature in impact testing, and this temperature becomes a criterion of compound quality in addition to the impact strength observed at specific temperatures. This BT (brittle fracture) has been investigated individuall in commercial and experimental elastomer modified rigid PVC compounds. Factors affecting the BT include speciman thickness, composition and processing conditions. Apparently the discontinuity in impact behavior is a sudden manifestation of a gradual change, resulting in a near ten‐fold decrease in notched impact strength without any obvious change in properties. The BT provides a continuous scale for comparing impact properties of compounds, and is thus more versatile and sensitive than impact tests run at a single temperature.
Some Transformations at the 12a-Position in the Tetracycline Series<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Transformations at the 12a-Position in the Tetracycline Series1Robert K. Blackwood, Hans H. Rennhard, and Charles R. StephensCite this: J. Am. Chem. Soc. 1960, 82, 19, 5194–5197Publication Date (Print):October 1, 1960Publication History Published online1 May 2002Published inissue 1 October 1960https://pubs.acs.org/doi/10.1021/ja01504a041https://doi.org/10.1021/ja01504a041research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Radiation Therapy Symposium: Introduction (2001)

David Ledney and Thomas M. Seed Catherine L. Wilhelmsen, Luann Mckinney, K. Sree Kumar, Venkataraman Srinivasan, G. Mark H. Whitnall, Thomas B. Elliott, Michael R. Landauer, William E. Jackson III, Protection Against Gamma-Irradiation with 5-Androstenediol In Vivo 2001, 226:625-627. Experimental Biology and Medicine http://ebm.rsmjournals.com/content/226/7/625 Updated information and services can be found at: http://ebm.rsmjournals.com/content/226/7/625#BIBL This article cites 4 articles, 0 of which can be accessed free at: http://ebm.rsmjournals.com/content/226/7/625#otherarticles 1 online articles that cite this articles can be accessed at:
Micrognathia, obstructive sleep apnoea and cor pulmonale--a case for tracheostomy. (1985)

A patient with congenital micrognathia, hypersomnia and severe pulmonary hypertension which resulted in sudden death during sleep is described. Hypersomnolence is a well-recognized manifestation of the pickwickian syndrome. A less recognized but similar disorder may affect patients with congenital or acquired micrognathia. The pathogenesis of this syndrome and obstructive sleep apnoea are reviewed. Tracheostomy timeously performed may be life-saving and the value of early resort to this apparently drastic procedure in a high-risk patient is emphasized.
Who's Looking After Alternative Filtration Technologies for Small Water Systems?—Part 1 (2002)

Alternative Filtration Technologies (AFTS) offer a number of advantages to small systems, the primary one being that they are often simpler to operate than filtration systems found in conventional water treatment plants. This first part of a two‐part article on AFTS will take a look at how AFTS are evaluated for approval and includes some tips for selecting an appropriate AFT. Next month, the second part will examine pitfalls to avoid regarding the operation and maintenance of AFTS.
Modulation of ex Vivo Cytokine Production by Splenocytes Using in Vitro Combined Therapeutics in Murine Retroviral Model (1999)

Altered levels of Type 1 and Type 2 cytokines are important in retrovirus-induced immunosuppression. The combination of immunostimulatory agents with antiviral drugs alters the course of murine retroviral infections. Previously, it was demonstrated that in vitro treatment of noninfected splenocytes and in vivo treatment of Friend leukemia virus (FLV)-infected mice with the combination of azidothymidine (AZT) and methionine enkephalin (MENK) significantly increases Type 1 cytokine levels and decreases Type 2 cytokines compared with treatment with only AZT. In order to study the effect of the time of initiation of immunomodulation on the course of retroviral infections, we examined the kinetics of cytokine production by isolated splenocytes from infected mice. BALB/c mice were infected with FLV, and spleen cells were removed at specified times postinfection (days 1, 3, 7, 10, and 14). Interleukin (IL)-2, interferon (IFN-gamma, IL-4, and IL-10 production by unstimulated or ConA-stimulated splenocytes treated in vitro with AZT, MENK, or AZT + MENK was determined after 48 h. The capacity of the isolated splenocytes to produce the Type 1 cytokines IL-2 and IFN-gamma in response to stimulation with ConA and combination therapy decreased over the course of infection. These results suggest that MENK treatment initiated later in the course of infection is unable to modulate the cytokine profile and would likely be ineffective in altering the course of FLV induced-disease. The results indicate the necessity to initiate antiretroviral therapy early in infection. Such information may be applicable in designing future regimens for HIV-1 infections in humans.
Technische Chemie 2002 (2003)

Abstract Der ökonomische und ökologische Druck auf Entwicklungsarbeiten in der Technischen Chemie steigt. Ansätze zur Kostensenkung und zu umweltfreundlicheren Verfahren finden sich daher immer häufiger, z. B. als Maßnahmen der Prozessintensivierung und als Innovationen in der Katalyse. Die Bioverfahrenstechnik gewinnt gegenüber klassischen chemischen Prozessen an Stellenwert.
The food supply chain in the post-petroleum bioeconomy (2014)

Atherosclerotic occlusive disease of the lower extremity in patients exhibiting severe rest pain, ulceration, or tissue necrosis represents a serious threat to extremities. In the past two decades the surgical approach in the treatment of lower extremity ischemia has changed significantly due to better understanding of segmental disease and infrapopliteal disease. Also, better visualization of leg and foot arteries due to improved angiographic and surgical techniques aided by magnification have all significantly contributed to increased limb salvage. Vein, when available, is the ideal graft material both for supra and infrapopliteal reconstruction. Availability of vein as a conduit can be increased when ectopic veins such as cephalic etc., are used and also when short segments of veins are used with unconventional distal inflow sites such as SFA, distal deep femoral artery, and popliteal artery. However, when vein is unavailable, PTFE graft is a good option particularly in patients with life expectancy of less than three years. Better understanding of graft failure has lead to better graft surveillance with PVR, ABI and Duplex scanning. Timely intervention with either PTA or surgery has lead to better secondary patency of grafts. Veith et al. looked at amputation rates during the period of changing therapeutic approach and found both a decrease in primary and secondary amputation rate implying the effectiveness of an aggressive therapeutic approach. Not all aspects of lower extremity disease are understood. However, infrapopliteal disease has now been addressed and new, innovative therapeutic approaches have made significant advances in limb salvage.
Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro (2018)

Severe vascular calcification develops almost invariably in chronic kidney patients posing a substantial risk to quality of life and survival. This unmet medical need demands identification of novel therapeutic modalities. We aimed to pinpoint components of the uremic microenvironment triggering differentiation of vascular progenitors to calcifying osteoblast-like cells. In an unbiased approach, assessing the individual potency of 63 uremic retention solutes to enhance calcific phenotype conversion of vascular progenitor cells, the pro-inflammatory cytokines IL-1β and TNF-α were identified as the strongest inducers followed by FGF-2, and PTH. Pharmacologic targeting of these molecules alone or in combination additively antagonized pro-calcifying properties of sera from uremic patients. Our findings stress the importance of pro-inflammatory cytokines above other characteristic components of the uremic microenvironment as key mediators of calcifying osteoblastic differentiation in vascular progenitors. Belonging to the group of "middle-sized molecules", they are neither effectively removed by conventional dialysis nor influenced by established supportive therapies. Specific pharmacologic interventions or novel extracorporeal approaches may help preserve regenerative capacity and control vascular calcification due to uremic environment.
Celecoxib, a Selective Cyclo-Oxygenase-2 Inhibitor, Enhances the Response to Preoperative Paclitaxel and Carboplatin in Early-Stage Non–Small-Cell Lung Cancer (2003)

In comparison with historically reported response rates, these data suggest that the addition of a selective COX-2 inhibitor may enhance the response to preoperative paclitaxel and carboplatin in patients with NSCLC. Moreover, treatment with celecoxib 400 mg twice daily was sufficient to normalize the increase in PGE2 levels found in NSCLC patients after treatment with paclitaxel and carboplatin. Confirmatory trials are planned.
Simultaneous prediction of the modulus and yield strength of binary polymer blends (1996)

Abstract A new scheme is proposed for the simultaneous prediction of the modulus and yield (or tensile) strength of binary blends, which employs a two‐parameter equivalent box model and the data on the continuity of constituents acquired from the percolation theory. Prediction of the elastic modulus in the linear stress‐strain region assumes “perfect” interfacial adhesion; at yielding (or breaking), the upper and lower bounds have to be distinguished, those bounds being related, respectively, to the interfacial adhesion sufficient and insufficient for the transmission of the acting stress. The modulus and the upper bound of yield (or tensile) strength are monotonic functions of the blend composition within the interval delimited by the values characterizing the components. The lower bound of strengths passes through a minimum (close to the 50/50 composition) linked to the minimum sum of the continuity parameters of the constituents. Predicted dependences of the modulus and of the yield (or tensile) strength on the blend composition are in a good accord with experimental data selected from literature.
A slit aperture for the monitoring x-ray experiment (MOXE) (1991)

We have investigated a slit aperture as an alternative to the square pinhole aperture for the MOXE detectors, which are to be put on the Soviet satellite Spectrum X-Gamma. A slit offers advantages for better discrimination of sources in crowded regions, eliminates the need for support structures for the aperture window, and does not compromise the signal-to-noise (S/N) of a point source. We find that in a single 24 hr pointing of the satellite, MOXE can determine the position of a 10 mCrab source to better than 0.5{degree} with the slit. The structure of a titanium grate which supports the detector's beryllium window constrains the slit to be 0.5 cm {times} 2.56 cm, oriented at an angle of 26.6{degree} to either side of the center lines of the detector. We illustrate an arrangement of the slits on each of the six detectors which optimizes source localization for a number of pointings. 4 refs., 8 figs., 4 tabs.