gebhart/patrepeval huggingface dataset:
Estudio de los genes implicados en la fisiopatología de la enfermedad de Parkinson (2013)

En la etiopatogenia de la enfermedad de Parkinson estan implicados factores toxico-ambientales y geneticos. Entre los factores toxico-metabolicos se encuentran los mecnismos de excitotoxicidad, neuroinflamacion, disfuncion mitocondrial y alteracion en la estructura proteica. Los factores geneticos relacionados con la enfermedad de Parkinson, no solo engloban la existencia de variaciones causativas sino tambien de riesgo para sufrir la enfermedad. Asimismo, se ha objetivado una interrelacion entre los factores toxico-ambientales y los geneticos. Se realiza un estudio de genes implicados en la fisiopatologia de la enfermedad de Parkinson como son el DNAJC6, FBXO7, SIRT1-SIRT6 y PSMC1. El acido urico, como factor toxico-metabolico es estudiado como factor relacionado con la enfermedad de Parkinson. De igual modo se evaluan las variaciones en genes relacionados con los valores de acido urico y el riesgo de sufrir enfermedad de Parkinson. Entre los resultados, se obtuvo que la mutacion c.801.pA>G en el exon 7 del DNAJC6 no se encontraba relacionada con enfermedad de Parkinson en nuestra poblacion. Igualmente, no se encontraron mutaciones en FBXO7 ni polimorfismos asociados a un mayor riesgo de enfermedad de Parkinson en SIRT1-SIRT6 y PSMC1. Por el contrario, niveles bajos de acido urico se objetivaron en la enfermedad de Parkinson, asi como una asociacion entre los polimorfismos en genes relacionados con los niveles de acido urico y el riesgo de sufrir enfermedad de Parkinson.
 Con ello, se concluye que los genes estudiados en nuestra muestra presentan una escasa implicacion en la enfermedad de Parkinson en nuestra muestra. El estudio de genes implicados en la fisiopatologia de la enfermedad de Parkinson no muestra una relacion en la etiopatogenia de la enfermedad. Entre los factores toxico ambientales, el acido urico bajo se asocia con la enfermedad de Parkinson asi como los polimorfismos en genes implicados en los niveles sericos a un mayor riesgo de sufrir la enfermedad.
Accelerating Vanishing Point-Based Line Sampling Scheme for Real-Time People Localization (2017)

In advanced video surveillance systems, people localization is usually a part of the complete system and should be accomplished in a short time so as to reserve sufficient processing time for subsequent high-level analysis, such as abnormal event/behavior detection and intruder detection. Hence, in addition to localization accuracy, computational efficiency is of critical importance as well. In this paper, we adopt a vanishing point-based line sampling scheme and propose a fast multicamera people localization approach capable of locating a crowd of dense people and estimating their heights in a fairly short time with high accuracy. For each camera view, sample lines, originated from a vanishing point, of foreground objects are projected onto the ground plane. Then, people locations are estimated by detecting the ground regions containing a high density of the projected lines. Enhanced from some previous works, the proposed approach does not require processing steps of high computation cost, such as projecting all foreground pixels of all views to multiple reference planes or computing pairwise intersections of projected sample lines at different heights. In addition, some novel acceleration modules, such as torso validation and physical rule-based filtering, are developed to further reduce the computation time of people localization. The experiments on real surveillance scenes validate that the proposed approach achieves significant speedup (up to 186%) over state-of-the-art techniques while still ensure a comparably high localization accuracy, even for crowded scenes with serious occlusions.
Combination antibiotic therapy is appropriate for nosocomial pneumonia in the intensive care unit. (1993)

Pneumonia in the intensive care unit (ICU) has been associated with highly virulent pathogens and mortality rates of 30% to 70%. Initial empirical therapy for pneumonia in the ICU remains controversial. Monotherapy with a broad-spectrum beta-lactam or fluoroquinolone may reduce toxicities associated with aminoglycosides but in nosocomial settings may fail to cover relevant pathogens and may promote antimicrobial resistance. Combining antibiotics that act by different mechanisms may achieve synergistic killing, expand the antimicrobial spectrum, and limit the emergence of antimicrobial resistance. Unfortunately, this approach may increase costs and toxicities. A plethora of studies have assessed monotherapy or combinations of antimicrobials for empirical treatment of fever in immunocompromised hosts, but these studies cannot be extrapolated to nosocomial pneumonia. Few studies have compared these disparate therapeutic strategies for nosocomial pneumonia. In this review, we emphasize the limitations of existing literature and present an approach to therapy of severe nosocomial pneumonia. Despite potential toxicities, aminoglycosides may have an important adjunctive role as empirical therapy of severe nosocomial pneumonias (pending clarification of the responsible organism) or when P aeruginosa, Acinetobacter spp, or beta-lactamase-producing aerobic gram-negative bacteria are suspected. The alarming increase in antimicrobial resistance noted in nosocomial settings in recent years, a trend that may be facilitated by extensive use of particular classes of antibiotics, provides a compelling argument in favor of combination therapy. Novel strategies employing beta-lactam and fluoroquinolone combinations also have promise.
Data Compaction - Compression without Decompression (2014)

Data compaction is a new approach for lossless and lossy compression of read-only array data. The biggest advantage over existing approaches is the possibility to access compressed data without any decompression. This makes data compaction most suitable for systems that could currently not apply compression techniques due to real-time or memory constraints. This is true for the majority of all computers, i.e. a wide range of embedded systems.
Analysis of a probe-fed short-circuited microstrip antenna (1996)

The input impedance of a probe-fed short-circuited microstrip antenna (SCMSA) is presented. The electric field expression under the microstrip patch by using the Wiener-Hopf technique is used and the electromotive force (EMF) method is applied. Analytical and experimental results for the impedance show the dependence on the dimensions and frequency.
Object-based data flow testing of web applications (2002)

Recently, the extraordinary growth in the World Wide Web has been sweeping through business and industry. Many companies have developed or integrated their mission-critical applications using Web technologies. As Web applications become complex, testing Web applications becomes crucial. This paper extends traditional data flow testing techniques to Web applications. Several data flow issues for analyzing HTML documents in Web applications are discussed. A test model that captures data flow test artifacts of Web applications is presented. In the test model, each component of a Web application is modeled as an object. The data flow information of the Web application is captured using flow graphs. From the test model, data flow test cases for the Web application then can be derived based on the intra-object, inter-object, and inter-client perspectives.
Recommendations for Dealing with Parents who Induce a Parental Alienation Syndrome in their Children (1998)

Abstract The parental alienation syndrome is commonly seen in highly contested child-custody disputes. The author has dcscribed three types: mild, moderate, and severe-each of which requires special approaches by both legal and mental health professionals. The purpose of this article is to correct some misinterpretations of the author's recommendations as well as to add some recently developed refinements. Particular focus is given to the transitional-site program that can be extremely useful for dealing with the scvcre type of, parental alienation syndrome. Dealing properly with parental-alienation— syndrome families requires close cooperation between legal and mcntal health professionals. Without such cooperation therapeutic approaches are not likely to succeed. With such cooperation the treatment, in many cases, is likely to be highly effective.
The value of serum levels of oestradiol, progesterone and β-human chorionic gonadotrophin in the prediction of early pregnancy loss (1992)

Serial serum levels of oestradiol, progesterone and the beta-subunit of human chorionic gonadotrophin (beta-HCG) had been performed in 674 cycles in women conceiving a singleton pregnancy, either spontaneously or as a result of assisted conception. To determine the value of these estimations in the prediction of early pregnancy loss, frequency distribution curves and receiver operating characteristic curves were derived for the respective hormones measured at weeks 4-7 of gestation and expressed as multiples of the median (MoM) values in pregnancies occurring both with and without ovarian stimulation. A cut-off level of beta-HCG less than 0.5 MoM gave a sensitivity of 68% with an odds ratio of 4.0 at 7 weeks in unstimulated cycles in the prediction of pregnancy failure. A cut-off of 0.8 MoM for progesterone gave a sensitivity of 59% and an odds ratio of 2.8. Prospective hormonal monitoring during the early weeks of gestation may be useful in the prediction of early pregnancy loss and should help to avoid the emergency presentation of some of the complications of early pregnancy, in particular ectopic pregnancy. The limitations imposed by multiple pregnancies and uncertain gestation due to menstrual data may restrict the use of this strategy to specialist fertility centres.
An efficient method to detect facial fiducial points for face recognition (2004)

In this paper, a completely automatic face recognition system is presented. It consists of two main modules: in the first, the facial fiducial points are localized, and in the second, the face is characterized applying a bank of Gabor filters in correspondence to the found fiducial points. This method is an evolution of the one we have presented; the fiducial point estimation is more efficient and self-correcting, and the face characterization is modified.
Easing Into Dechlorination (2004)

This article discusses how utilities are struggling to adapt to new regulations that require the neutralization of chlorine at the time of discharge. Both the US Environmental Protection Agency's Clean Water Act standards and the Canadian Environmental Protection Act guidelines state that water to be discharged into both freshwater and marine waters must contain less than 0.02 mg/L chlorine, less than 2% of the usual chlorine concentration in potable water in most distribution systems. Proper dechlorination before discharging water is critical in preventing irreversible environmental damage. The article focuses on the difficulties of dechlorination, equipment and chemicals used for dechlorination, and how to choose the best method for your needs.
Derivation of neointima in vascular grafts. (1988)

Vascular prostheses woven from absorbable lactide/glycolide copolymers are replaced by myofibroblast-laden tissue conduits lined by endothelium. When these prostheses are implanted in arteries of animal models, the absorption-replacement reactions are inhibited by Dacron. To determine whether these reactions resulted primarily from transanastomotic pannus ingrowth, prostheses (30 mm x 4 mm) were constructed of three 10-mm long segments with Dacron segments on both ends and a middle polyglactin 910 (PG910) segment. The prostheses were implanted in the aortas of 15 adult New Zealand White rabbits. Resultant prosthesis/tissue complexes were harvested in triplicate at 2 weeks and at 1, 2, 3, and 4 months after implantation. Explants were photographed and sectioned for light microscopy and for scanning and transmission electron microscopy, which showed 100% patency with no aneurysms or stenoses. Inner-capsule thickness in the PG910 segments increased only during the interval from 2 weeks to 2 months; this thickness was statistically greater than either Dacron segment at 1 and 2 months (p less than or equal to 0.004 and p less than or equal to 0.0001, respectively). Proximal and distal Dacron segments did not differ from each other in thickness. Inner capsules of PG910 segments at 1 month were composed predominantly of myofibroblasts, whereas inner capsules of Dacron segments were composed of fibrin coagulum beyond the initial 2 mm of endothelial pannus ingrowth. These data suggest that transanastomotic pannus ingrowth is not the primary source of cells replacing absorbable vascular prostheses.
Vapor-phase charge-transfer complexes. 10. Iodine complexes of methanol, ethanol, and diethyl ether (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-phase charge-transfer complexes. 10. Iodine complexes of methanol, ethanol, and diethyl etherHing-Cheung Tse and Milton TamresCite this: J. Phys. Chem. 1977, 81, 21, 1977–1982Publication Date (Print):October 1, 1977Publication History Published online1 May 2002Published inissue 1 October 1977https://pubs.acs.org/doi/10.1021/j100536a003https://doi.org/10.1021/j100536a003research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Extractor codes (2001)

We define new error correcting codes based on extractors. We show that for certain choices of parameters these codes have better list decoding properties than are known for other codes, and are provably better than Reed-Solomon codes. We further show that codes with strong list decoding properties are equivalent to slice extractors, a variant of extractors. We give an application of extractor codes to extracting many hardcore bits from a one-way function, using few auxiliary random bits. Finally, we show that explicit slice extractors for certain other parameters would yield optimal bipartite Ramsey graphs.
Reducing the OBGP protection switching time in WDM mesh networks (2006)

In this paper, a fast protection switching scheme based on the parallel restoration signaling, parallel restoration scheme (PRS), is introduced into the optical border gateway protocol (OBGP) in survivable optical mesh networks. In the PRS, the message for resource reservation along the backup lightpath is forwarded to the upstream autonomous system (AS) ahead of the optical cross connects (OXC) reconfiguration when the working path fails. Compared with the traditional serial restoration scheme (SRS), the PRS can reduce the mean time of protection switching from the working path to the backup path according to theory analyses and simulation experiments. Numerical results demonstrate that the protection time is decreased by more than 50%, if the PRS is applied.
Stark-induced three-wave mixing in molecular gases - Part I: Theory (1977)

Application of dc electric field to a gaseous system destroys the basic inversion symmetry and allows three-wave mixing processes to occur. A theoretical derivation of this effect under conditions of resonantly enhanced nonlinearities is given for a three-level system. Calculations are presented for mixing of a CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> laser with 4-GHz microwaves in the molecule NH <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> D, producing single lower sideband radiation.
Effect of olive waste (Husk) on behavior of cement paste (2016)

Jordan is a famous country in terms of olive trees agriculture that resulted in a mass production of olive oil products. The huge amounts of olive waste (husk) that resulted from olives processing to produce olive oil represent an environmental challenge in the country. The idea in this paper comes to use olive waste as a partial replacement for Portland cement in cement paste to conserve the environment, reduce cement consumption and increase cost efficiency. The wastes were burned properly in an oven and maintained for 6 h until it was fully transformed into ashes. Then, the oven was turned off and ashes were allowed to cool. After cooling, the material passed sieve #200 were used. The sieved ashes were used in the cement mix as a partial cement replacement for making the mortar and cement paste. Normal consistency and setting time were determined as well as soundness, compressive strength. Results indicated that normal consistency of the cement pastes containing different percentage of olive waste is somehow lower than that of the ordinary cement paste and slightly decreases with increasing the percentage. The results also indicated that the compressive strength of hardened blended cement paste containing different percentages of olive waste slightly decrease with olive waste content at 3, 7, and 28 days.
Effective bandwidth (2014)

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Surgical-orthodontic treatment of two skeletal Class III patients with Invisalign and fixed appliances. (2005)

2000 by Boyd, Vlaskalic, and Miller.1 Since then, a number of case reports1-19 and two clinical trials20-22 have demonstrated the applications of this system in many different types of orthodontic treatment. To date, more than 250,000 patients around the world have had Invisalign treatment23—a remarkably high number considering the appliance has been available to clinicians for less than five years. One of the longitudinal clinical trials found that Invisalign had limitations in terms of tooth movement, with tipping movements being the most predictable.20,21 The appliances in this study, however, were made of materials that are no longer used, and they were changed at two different time intervals (one or two weeks), before the current protocol of two weeks for each aligner was established. Another longitudinal study has been reported only as an abstract.22 One of the primary advantages found in both studies was a statistically significant reduction in plaque and gingivitis.21,22 With fixed appliances, patients typically show an increase in plaque and gingivitis throughout orthodontic treatment; in fact, some patients experience irreversible bone loss,24,25 especially on banded molars,26 as well as decalcification.25,27-29 The present article demonstrates the use of Invisalign appliances in two of the most difficult types of orthodontic patients—skeletal Class III cases requiring singleor two-jaw multiple-segment orthognathic surgery.
AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis (1998)

We have previously shown that the protein Eps15 is constitutively associated with the plasma membrane adaptor complex, AP-2, suggesting its possible role in endocytosis. To explore the role of Eps15 and the function of AP-2/Eps15 association in endocytosis, the Eps15 binding domain for AP-2 was precisely delineated. The entire COOH-terminal domain of Eps15 or a mutant form lacking all the AP-2-binding sites was fused to the green fluorescent protein (GFP), and these constructs were transiently transfected in HeLa cells. Overexpression of the fusion protein containing the entire COOH-terminal domain of Eps15 strongly inhibited endocytosis of transferrin, whereas the fusion protein in which the AP-2-binding sites had been deleted had no effect. These results were confirmed in a cell-free assay that uses perforated A431 cells to follow the first steps of coated vesicle formation at the plasma membrane. Addition of Eps15-derived glutathione-S-transferase fusion proteins containing the AP-2-binding site in this assay inhibited not only constitutive endocytosis of transferrin but also ligand-induced endocytosis of epidermal growth factor. This inhibition could be ascribed to a competition between the fusion protein and endogenous Eps15 for AP-2 binding. Altogether, these results show that interaction of Eps15 with AP-2 is required for efficient receptor-mediated endocytosis and thus provide the first evidence that Eps15 is involved in the function of plasma membrane-coated pits.
Development and Laboratory Investigations of a Denuder Sampling System for the Determination of Heavy Metal Species in Flue Gases at Elevated Temperatures (1990)

Abstract A denuder sampling system was developed to measure volatile metals at elevated temperatures. By using the denuder technique it is possible to avoid condensation and adsorption losses in the sampling line. To investigate the behavior of heavy metal species under different physical and chemical conditions, a laboratory scale quartz stack was built. Metal aerosol generators based on evaporation, diffusion and condensation are described. The diameter of the generated particles varied between 0.05–0.3 μm. The day to day reproducibility of the generation varied between 0.6-5.0% for chromium and 2.8–4.0% for cadmium (95% stat. significance). Denuders coated by elemental silver seem to be an efficient means for sampling of elemental Cd at 200°C. The diffusion coefficient of Cd was calculated from experimental data, and the value of (0.42±0.04) cm2/s was obtained. A detection limit of 0.2 μg/m3 for Cd determination can be reached by using a Ag-denuder, when a sampling time of 30 min and a flow rate of 60l/h is employed.
Hierarchical Correlation Compensation For Hidden Markov Models (2006)

In this paper, we present a hierarchical correlation compensation (HCC) scheme to reliably estimate full covariance matrices (CMs) for Gaussian components in CDHMMs for speech recognition. First, we build a hierarchical tree in the covariance space, where each leaf node represents a Gaussian component in the CDHMM set. For all lower-level nodes in the tree, we estimate a diagonal CM as usual. But we estimate full matrices for all upper-level nodes since they have large amount of data. For each Gaussian in a leaf node (with diagonal components estimated already), we compensate its off-diagonal components by using a linear combination of a set of prototype CMs, which includes the estimated CMs of all nodes in the tree along the upward path from the leaf all the way to the root. Finally, the linear combination weights are estimated based on the ML criterion. We have evaluated the HCC on the DARPA resource management task and an in-house large-vocabulary Chinese dictation task. We have achieved significant error reduction over the best diagonal CM models. Experimental results also show that HCC yields better performance than other full covariance modeling schemes.
Fibrin assembly in human plasma and fibrinogen/albumin mixtures. (1986)

International audience
Cytokine network in rectal mucosa in perianal Crohnʼs disease: Relations with inflammatory parameters and need for surgery (2008)

The cytokines network analysis in perianal CD shows the important involvement of IL-1 beta, IL-6, and TNF-alpha. Furthermore, mucosal levels of IL-6 and IL-12 are predictors of recurrence and of need for surgery in perianal CD patients.