gebhart/patrepeval huggingface dataset:
Axonal Tau mRNA Localization Coincides with Tau Protein in Living Neuronal Cells and Depends on Axonal Targeting Signal (2001)

Subcellular mRNA localization, a fundamental mechanism for regulating gene expression, leads to local protein translation that results in the generation of neuronal cell polarity. In this study, we have used P19 embryonic carcinoma cells, which are amenable to transfection, and selection of clonal stable cell lines that are not overexpressing the constructs. We identified the 3' untranslated region (3'UTR) tau axonal localization signal and examined its effect on tau protein localization in nondifferentiated and neuronally differentiated P19 cells. Using GFP-tagged tau constructs combined with in situ hybridization analysis, we demonstrated colocalization of the targeted tau mRNA and its translated protein in the axon and growth cone. Absence of or mutation in the 3'UTR axonal targeting region of tau mRNA resulted in suppression of tau mRNA localization, and both tau mRNA and tau protein remained in the cell body. Swapping between the 3'UTR tau mRNA axonal localization signal and the 3'UTR MAP2 mRNA dendritic targeting signal proved that the localization of the proteins into the axon or dendrites depends on the specific 3'UTR targeting signals. Moreover, the identification of ribosomal proteins in the axon lends further support to the presence of protein synthetic machinery in the axons, a prerequisite for local translation. It is suggested therefore that the P19 cell system can be used to analyze mutations that affect mRNA transport and local translation and that it has the potential of being used to examine the onset of the neuronal differentiation process.
A historic survey of transaction management from flat to grid transactions (2005)

This is a working paper for the XTraConServe (XTC) Project, which aims\nto develop concepts and support facilities for a Business Transaction\nFramework (BTF) that utilizes abstract transactional constructs (ATCs) to\nprovide a generic foundation for support of complex transactional services\nin contract-driven inter-organizational business interactions that rely on\ndynamically composed web services. In this paper, we investigate the\nclassical transaction models and the key concepts and techniques with\nregard to transaction management. Some well-known work that has been or\nis being done in different application domains is reviewed following a time\nline, which reveals the development of transactions from the simplest nostructure\nmodel to the complex framework with hierarchical or layered\nstructures.
Template-free synthesis of mesoporous spinel lithium titanate microspheres and their application in high-rate lithium ion batteries (2009)

Mesoporous spinel lithium titanate Li4Ti5O12 microspheres were prepared by template-free hydrothermal process in ethanol–water mixed solution and subsequent heat treatment. The role of ethanol helps the formation of a mesoporous structure during the hydrothermal process. A mechanism analogous to the Kirkendall effect was proposed to account for the template-free formation of these mesoporous nanostructures. As anode materials for high-rate lithium ion battery, the Li4Ti5O12 mesoporous spheres exhibited superior high-rate performance of 114 mA h g−1 at 30C and good capacity retention of 125 mA h g−1 after 200 cycles at 20C, which indicates promising application in high-rate lithium ion batteries.
Comparative analysis of essential oils from the leaves of wild and domestic Chimonanthus praecox (2012)

Characteristics of leaf essential oil extracted by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS) from wild and domestication Chimonanthus praecox from Wanyuan City of Sichuan, China, were investigated. Their leaves had twenty-two common essential oil components containing the mains bornyl acetate, caryophyllene oxide and (-)-spathulenol. Their oils were characterized by sesquiterpenes and monoterpenes, especially, the oxygenated. However, the wild plants possessed higher essential oil content and more abundant chemical components than the domestication variety “Suxinmei”. The wild plants possessed sixty-four special components such as o-cymene, eucalyptol, γ-terpinene, linalool, etc, and most of them have enjoyable flavor and curative effect. But, “Suxinmei” was only with the three special components α-muurolene, γ-elemene and γ-himachalene, and without aromatic compounds. These results suggested that partial genetic materials controlling some especial nature products might have been changed or lost in the processes of evolution and domestication from wild to cultivar. It is of importance to powerfully protect and rationally utilize wild C. praecox germplasm resources.

	 

	Key words: Chimonanthus praecox, germplasm resources, leaf, hydrodistillation, GC-MS, essential oil, yield, chemical component.
Left Ventricular Model Using Second Order Electromechanical Coupling: Effects Of Viscoelastic Damping (2007)

It is known that the heart interacts with and adapts to its venous and arterial loading conditions. Various experimental studies and modeling approaches have been developed to investigate the underlying mechanisms. This paper presents a model of the left ventricle derived based on nonlinear stress-length myocardial characteristics integrated over truncated ellipsoidal geometry, and second-order dynamic mechanism for the excitation-contraction coupling system. The results of the model presented here describe the effects of the viscoelastic damping element of the electromechanical coupling system on the hemodynamic response. Different heart rates are considered to study the pacing effects on the performance of the left-ventricle against constant preload and afterload conditions under various damping conditions. The results indicate that the pacing process of the left ventricle has to take into account, among other things, the viscoelastic damping conditions of the myofilament excitation-contraction process.
Standards of Medical Care in Diabetes–2006 (2006)

We appreciate Dr. Tseng’s letter (1), as it identifies an error in our 2006 stated HDL cholesterol goals (2), when expressed in SI units, and allows us to comment further on our recommendation regarding the use of statins in those with type 2 diabetes.

Tseng is correct that the 2006 goals for HDL (2) should read 40 mg/dl (1.03 mmol/l) for men …
Comparative evaluation of the olive oil given by a new processing system (1997)

Abstract To evaluate the level of quality of the olive oil given by a new processing system we compared it with the percolation oil, which is known to be of high quality. The new product was characterized by the following: (i) higher contents of tocopherols, tyrosol- and hydroxytyrosol-aglycones, volatile aromatic substances, sterols, triterpene alcohols and lipochromes, and higher values of 1,2-diglycerides/1,3-diglycerides and campesterol/stigmasterol ratios, colour indices and turbidity; (ii) lower contents of waxes and triterpene dialcohols, and lower values for spectrophotometric indices, carbonyl index, Wolff's ratio (K232/K270), acidity, and peroxide number; (iii) similar contents of phenols, o-diphenols, free tyrosol, free hydroxytyrosol, triglycerides, stigmastadienes, and aliphatic alcohols, similar sensory score, and similar value of resistance to autoxidation, alcohol index, overall quality indices, and fatty acid composition.
Location-Aware Access to Hospital Information and Services (2004)

Hospital workers are highly mobile; they are constantly changing location to perform their daily work, which includes visiting patients, locating resources, such as medical records, or consulting with other specialists. The information required by these specialists is highly dependent on their location. Access to a patient's laboratory results might be more relevant when the physician is near the patient's bed and not elsewhere. We describe a location-aware medical information system that was developed to provide access to resources such as patient's records or the location of a medical specialist, based on the user's location. The system is based on a handheld computer which includes a trained backpropagation neural-network used to estimate the user's location and a client to access information from the hospital information system that is relevant to the user's current location.
Analgesic activity and central nervous system distribution of the optical isomers of pentazocine in the rat. (1971)

Onset, intensity and duration of analgesia produced by the dl -, d -and l -isomers of pentazocine were measured by the blockade of the pain response elicited by i.a. bradykinin administration. Most of the analgetic activity of pentazocine was found to reside in the l -isomer; the d -isomer was weakly analgetic at 15 mg/kg. Peak analgesia appeared to correlate reasonably well with brain and plasma levels of pentazocine, estimated by a spectrophotofluorometric procedure with a sensitivity 0.1 µg of drug per g of brain and 0.04 µg/ml of plasma. After a 15 mg/kg dose s.c., central nervous system and plasma levels of all three pentazocine isomers reached maximal values within 30 minutes. Levels of the d -isomer in eight brain regions (cortex, cerebellum, medulla-pons, midbrain, hypothalamus, hippocampus, striatum and cord) tended to be slightly higher and to fall more rapidly than those of the l -and the dl -isomers. Early levels of all three isomers were found to be highest in the cortex or hypothalamus and lowest in the cord but the differences between the two areas were generally less than 20%. Differences in the regional central nervous system distribution of the optical isomers of pentazocine failed to account for their differences in pharmacologic activity.
Morbidity of percutaneous tube thoracostomy in trauma patients (2002)

PTT is associated with significant morbidity and extended hospitalizations, partly related to inappropriate training of all individuals dealing with trauma care. Additional training should be recommended and some conventional indications for PTT should be revised. A prospective study is currently in progress to evaluate the benefit of early videothoracoscopy in trauma and failure of primary PTT.
Possible stabilization of the frequency of a CO<sub>2</sub>laser using an external Stark cell containing 1-1 difluoroethane (1979)

Results are presented of measurements of the Stark modulation index and absorption coefficient of CO2 laser radiation due to the P(24) line by 1-1 difiuorethane (C2H4F2). The possibility of stabilizing the CO2 laser frequency using a Stark cell is demonstrated and the laser frequency tuning efficiency within the P(24) line of the 00o1–10o0 transition is determined.
Accurate acoustic ranging system using android smartphones (2017)

ACCURATE ACOUSTIC RANGING SYSTEM USING ANDROID SMARTPHONES By Mohammadbagher Fotouhi, Master of Science A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University 2017 Major Director: Dr. Ruixin Niu, Associate Professor of Department of Electrical and Computer Engineering In this thesis, we present the design, implementation, and evaluation of an android ranging system, a high-accuracy acoustic-based ranging system which allows two android mobile phones to learn their physical distance from each other. In this system we propose a practical solution for accurate ranging based on acoustic communication between speakers and microphones on two smartphones. Using the audible-band acoustic signal with the Wi-Fi assistance without the sound disturbance is promising for large deployment. Our method is a pure software-based solution and uses only the most basic set of commodity hardware: a speaker, a microphone, and Wi-Fi communication. So it is readily applicable to many commercial-off-the-shelf mobile devices like cell phones. Our system is the result of several design goals, including user privacy, decentralized administration, and low cost. Rather than relying on any centralized management which tracks the user’s location to help them find their distance, our system helps devices learn their distance from each other without advertising their location information with any centralized management. Compared to alternatives that require special-purpose hardware or pre-existence of precision location infrastructure , our system is applicable on most of off-the-shelf components so it is a commodity-based solution will obviously have wider applications and is cost effective. Currently, two smartphones are used to estimate the distance between them through Wi-Fi and audio communications. The basic idea is estimating the distance between two phones by estimating the traveling time of audio signal from one phone to the other as the speed of sound is known. The preliminary results of ranging demonstrate that our algorithm could achieve high accuracy, and stable and reliable results for real time smartphone-based indoor ranging.
Vaccination therapy with tumor-dendritic cell hybrids: a promising therapeutic approach? (2005)

Dendritic cells (DCs) are potent antigen-presenting cells currently being investigated as a tool for antitumor vaccination strategies. As an alternative to loading DCs with tumor antigen preparations, hybrid cells generated by fusing tumor cells with DCs have successfully been evaluated in preclinical cancer models. Hybrid cells express a large repertoire of tumor-associated antigens, high levels of major histocompatibility complex class I and II molecules, and adhesion/co-stimulatory molecules. Therefore, these cells possess properties of both parental cell types that are necessary for the induction of primary helper and cytotoxic T-cell responses. The results of early clinical trials suggest that hybrid cell vaccination is a safe and well-tolerated procedure capable of inducing T-cell responses. However, the few objective clinical responses observed indicate that further optimizations are required.
Mechanical Properties of PVC Complexes Using Waste-Gypsum (I) (2002)

In this study, mechanical properties of PVC complexes containing the gypsum (Namhae Chemical Co.) which contains phosphte, CaO, etc., Pb-species stabilizer, and were investigated as a function or the content. As a result, mechanical properties increased when the gypsum was mixed with PVC at the extent of 8.46wt%. From this result, it is suggested that the gypsum containing phosphate and CaO is compatible with PVC. Thermogravimetric analysis(TGA) showed that pyrolysis started about at , and residual weight(%) increased with the amount of the gypsum, and differential scanning calorimetry (DSC) showed that had the maximum and minimum value respectively when the gypsum was mixed with PVC at the extent of 8.46wt%. Comparing all the results, both mechanical and thermal properties of PVC complex were improved. The X-ray diffraction measurement also showed their blonds and structures.
A human-robot interface using an interactive hand pointer that projects a mark in the real work space (2002)

A human-robot interface system is under development that takes into account the flexibility of the DigitalDesk approach. The prototype consists of a projector subsystem for information display and a real-time tracking vision subsystem to recognize the human's action. Two levels of interaction using a virtual operational panel and interactive image panel have been developed. This paper presents the third subsystem, the interactive hand pointer used for selecting objects or positions in the environment via the operator's hand gestures. The system visually tracks the operator's pointing hand and projects a mark at the indicated position using an LCD projector. Since the mark can be observed directly in the real work space without monitor displays or HMDs, correction of the indicated position by moving the hand is very easy for the operator. The system enables projection of a mark not only at a target plane with a known height but also to a plane with an unknown height. Experimental results of a pick-and-place task demonstrate the usefulness of the proposed system.
Long-Term Results of an Intensive Treatment Program for Adults and Adolescents Who Stutter (1994)

In order to determine the long-term effects of an intensive treatment program, 17 adult and 25 adolescent stutterers were tested 2 or 3 times during a 12- to 24-month post-intensive treatment phase. The results of this study are intended to augment and supplement the growing body of evidence about the effects of intensive treatment programs on adult and adolescent stutterers. Follow-up measures included surprise phone calls to clients at home/work and a self-administered Speech Performance Questionnaire. Careful training of speech raters was undertaken to ensure high reliability of speech measures. Results from the phone call samples indicated that about 69% of the subjects maintained a satisfactory level of post-treatment fluency, with an additional 7% maintaining a level that was judged to be marginally satisfactory. On the self-administered Questionnaire, 80% of the subjects rated their speech fluency as good or fair 12 to 24 months after treatment.
Written representation of topics and the production of query terms (1971)

Abstract The set of different terms used to search a directory for information on a given topic varies considerably from one searcher to another. If the topic is represented by a written text, the characteristics of the text are among the variables which influence the formulation of search terms. The results of an experiment simulating a library catalog search indicated that a relation exists between the lexical content load of the text, used to define the search topic, and the number of query terms generated by a group of experimental subjects (college students). No connection was found between the content load of the text and the commonality of query term choices. Some of the properties of “popular” as opposed to “unique,” query terms were examined. Only short terms enjoyed a high level of popularity. The repeated appearance of a term in the text favored the selection of that term by a large number of searchers.
Engendering rural information systems in Indonesia (2005)

There is still a long road ahead before all Indonesian's can benefit from the full potential of ICT. That road seems even longer to rural women. Despite some improvements in access and the rapid deployment of lower cost wireless technologies, not much has changed in rural areas of Indonesia. Infrastructure in rural areas is limited and existing services are expensive and practically outside of rural women's reach. Women still face enormous barriers and access to communications and information relevant to their realities is very limited. This report provides a gender perspective on the status of ICT in rural areas of Indonesia and presents the main findings of our gender analysis. The discussion is illustrated by case studies (see Appendices on p.42) developed by the core team responsible for the preparation of this report and based on the field research.
Radiation, Cancer, and Environmental Health (1970)

Accumulating data on radiation carcinogenesis, both epidemiologic and experimental, indicate that current governmental safety standards for environmental radiation are far too high. The inadequacy of present regulatory processes in this area points to the need for a radically revised approach to controlling environmental contaminants of all kinds.
Beta-Adrenergic receptor interactions. Direct comparison of receptor interaction and biological activity. (1976)

Iodohydroxybenzylpindolol (I-HYP) is a chemically defined, high affinity, high specific activity beta-adrenergic antagonist that interacts with a single site on the turkey erythrocyte membrane. Study of the interaction of agonists, antagonists, and congeners with this site and concomitant alterations in adenylate cyclase activity have been carried out in the presence of high or low concentrations of guanine nucleotide. The results help clarify the relationship between binding and activation or inhibition of adenylate cyclase and the role of guanine nucleotides in modulating this interaction. There is a close correlation between binding constants (KD) for inhibitors determined by analysis of competitive displacement of 125I-HYP from receptor, and apparent affinities (Ki) for inhibition of adenylate cyclase. For activators, however, there is up to a 10-fold difference between KD and apparent affinity (KDapp) for adenylate cyclase activation at low guanine nucleotide concentration (10(-6) M guanylylimidodiphosphate). This difference is virtually abolished by employing higher nucleotide concentrations (10(-5) M guanylylimidodiphosphate) without significantly altering receptor affinity. This suggests that guanine nucleotides act by modulating receptor-enzyme interactions rather than hormone-receptor interactions. Moreover, several beta-adrenergic analogs previously shown to have no effect on adenylate cyclase in the absence of nucleotide, are partial agonists in the presence of 10(-5) M guanylylimidodiphosphate. Parallel analyses for a series of agonists and antagonists for adenylate cyclase activation and receptor interaction show affinities for levorotatory isomers generally 100-fold greater than for dextrorotatory isomers. Thus stereoconfiguration at the beta carbon clearly influences affinity of agonists or antagonists. Affinity is also importantly influenced by the nature of the aromatic ring as well as the N-alkyl group. The complexity of structure-function relationships for these compounds requires a redefinition of structural requirements for beta-adrenergic activity.
NEGATIVE MAGNETORESISTIVITY OF RAPIDLY QUENCHED SUPERCONDUCTING ALLOY AI-11.3 at% Si (1981)

The effect of heat treatment on the m icrostructure and super-conducting properties of the eutectic alloy A1-11.3 at% Si prepared by the splat quenching technique has been studied. The negative magnetoresistivity in super conducting-normal transition was observed in the sample after annealing at 100℃ for 50 hours. Our results reveal the existence of two superconducting phases in this sample.
Bis[14β-hydroxy-3β-<i>O</i>-(<scp>L</scp>-thevetosyl)-5β-card-20(22)-enolide] methanol solvate monohydrate and 3β-<i>O</i>-(<scp>L</scp>-2′-<i>o</i>-acetylthevetosyl)-14β-hydroxy-5β-card-20(22)-enolide (2003)

The title compounds, 2C(30)H(46)O(8).CH(3)OH.H(2)O, (I), and C(32)H(48)O(9), (II), respectively, are cardenolide glycosides which were isolated from the seeds of Cerbera odollam. There are two crystallographically independent cardenolide molecules in (I), together with one methanol and one water solvate molecule. In both (I) and (II), the steroid nuclei are in cis/trans/cis configurations, with the cyclopentane rings showing conformational flexibility, viz. an envelope conformation in (I) and a twisted conformation in (II). In both compounds, the lactone ring is nearly orthogonal to the cyclopentane ring. The packing of (I) is composed of molecular layers stabilized by five O-H...O hydrogen bonds. In the packing of (II), the molecules are packed into columns by one O-H...O hydrogen bond, and are further interconnected into a three-dimensional network by one O-H...O and three C-H...O interactions.
Chemical, bacteriological, and toxicological properties of cyanuric acid and chlorinated isocyanurates as applied to swimming pool disinfection: a review. (1974)

Chemical, bacteriological, and toxicological properties of cyanuric acid and chlorinated isocyanurates as applied to swimming pool disinfection: a review. E CanelliCopyRight https://doi.org/10.2105/AJPH.64.2.155 Published Online: October 07, 2011