gebhart/patrepeval huggingface dataset:
Radioactive Ion Beam Production Capabilities At The Holifield Radioactive Ion Beam Facility (2011)

The Holifield Radioactive Ion Beam Facility (HRIBF) is a national user facility for research with radioactive ion beams (RIBs) that has been in routine operation since 1996. It is located at Oak Ridge National Laboratory (ORNL) and operated by the ORNL Physics Division. The principal mission of the HRIBF is the production of high quality beams of shortlived radioactive isotopes to support research in nuclear structure physics and nuclear astrophysics. HRIBF is currently unique worldwide in its ability to provide neutron‐rich fission fragment beams post‐accelerated to energies above the Coulomb barrier for nuclear reactions. HRIBF produces RIBs by the isotope separator on‐line (ISOL) technique using a particle accelerator system that consists of the Oak Ridge Isochronous Cyclotron (ORIC) driver accelerator, one of the two Injectors for Radioactive Ion Species (IRIS1 or IRIS2) production systems, and the 25‐MV tandem electrostatic accelerator that is used for RIB post‐acceleration. ORIC provides a light ion beam (proton, deuteron, or alpha) which is directed onto a thick target mounted in a target‐ion source (TIS) assembly located on IRIS1 or IRIS2. Radioactive atoms that diffuse from the target material are ionized, accelerated, mass selected, and transported to the tandem accelerator where they are further accelerated to energies suitable for nuclear physics research. RIBs are transported through a beam line system to various experimental end stations including the Recoil Mass Spectrometer (RMS) for nuclear structure research, and the Daresbury Recoil Separator (DRS) for nuclear astrophysics research. HRIBF also includes two off‐line ion source test facilities, one low‐power on‐line ISOL test facility (OLTF), and one high‐power on‐line ISOL test facility (HPTL). This paper provides an overview and status update of HRIBF, describes the recently completed $4.7M IRIS2 addition and incorporation of laser systems for beam production and purification, and discusses a proposed replacement of the ORIC driver accelerator.
Radioimmunological Imaging of Metastatic Prostatic Cancer with<sup>111</sup>Indium-Labeled Monoclonal Antibody Pay 276 (1987)

A total of 25 patients with histologically proved adenocarcinoma of the prostate, whose disease was staged clinically as D2 by appropriate radiographic and nuclear medicine studies, received increasing doses of PAY 276, an antiprostatic acid phosphatase monoclonal antibody for radioimmunological imaging. The patients were divided into 5 groups of 5. Groups 1 through 5 received an infusion of 5, 10, 20, 40 or 80 mg. monoclonal antibody, respectively, 1 mg. of which was labeled to 5 mCi. of 111indium, while stable monoclonal antibody was added to achieve the desired antibody concentration. No patient had an allergic reaction, and no significant change in serial hemoglobin levels, platelet count, chemistry profile or results of urinalyses was noted. The monoclonal antibody scan visualized at least 1 lesion in 19 of 25 patients (76 per cent): 4 in groups 1 and 2, and all 15 in groups 3 to 5. With results of conventional radiography and bone scintigraphy considered definitive for metastases, monoclonal antibody scans detected 7 of 32 metastases (21.8 per cent) in group 3 (20 mg.), 31 of 58 (53.4 per cent) in group 4 (40 mg.) and 101 of 134 (75.4 per cent) in group 5 (80 mg). In group 5 the incidence of false positive and false negative scans was 2.3 per cent (3 of 132) and 24.6 per cent (33 of 134), respectively. The detection of metastatic lesions increased as the concentration of unlabeled monoclonal antibody increased. Radioimmunological imaging of prostatic cancer with antiprostatic acid phosphatase monoclonal antibody seems to be feasible.
Adaptive polarimetric tuning for improved radar target classification using MACH filters (2005)

In this paper we report on the development of a technique for adaptive selection of polarization ellipse tilt, and ellipticity angles such that the targets separation from clutter is maximized. From the radar scattering matrix [S] and its complex components, in-phase and quadrature phase, the elements of Mueller/Kennaugh matrix are obtained. Then by means of polarization synthesis, the radar cross section of the radar scatterers at different transmitting and receiving polarization states are obtained. By designing a maximum average correlation height filter, a target vs. clutter distance measure is derived as function of four transmit and receive polarization state angles. The results of applying this method on real synthetic aperture radar imagery indicate a set of four transmit and receive angles which lead to maximum target vs. clutter discrimination. These optimum angles are different for different targets. Hence by adaptive control of the state of polarization of polarimetric radar, one can noticeably improve discrimination of targets from clutter.
ENERGY TRANSFER IN SOME MIXED MOLECULAR CRYSTALS (1972)

Author Institution: Department of Chemistry, University of Michigan
The potential role for cladribine in the treatment of multiple sclerosis: clinical experience and development of an oral tablet formulation (2007)

Preliminary data indicate that cladribine is effective for the treatment of MS and has a promising safety and tolerability profile. The sustained immunologic effects of cladribine make it suitable for intermittent oral dosing, which is expected to offer benefits for patient satisfaction and therapeutic adherence.
ChemInform Abstract: REAKTIVITAET ELEKTRONENREICHER OLEFINE 6. MITT. RK. VON AETHYLENTETRAAMINEN MIT CARBOXAMIDEN UND CARBOXHYDRAZIDEN (1975)

Abstract Die Äthylentetramine (I) reagieren mit den entsprechenden Carbonsäureamiden (II) zu den Imidazolidinen (III).
Mit S‐S‐reduzierendem Reagenz und CE‐LIF (2000)

Abstract Die laserinduzierte Fluoreszenz eignet sich als ein sehr schnelles Verfahren für die Detektion von Thiolen in Plasma. Es gelingt die Trennung von Homocystein und verschiedenen Thiolen, die im Metabolismus von Glutathion beteiligt sind.
Spotlight (2008)

ADVERTISEMENT RETURN TO ISSUEPREVSpotlightNEXTSpotlightEva J. Gordon, Jason G. Underwood, and Anirban MahapatraCite this: ACS Chem. Biol. 2008, 3, 2, 80–83Publication Date (Web):February 15, 2008Publication History Received29 January 2008Accepted29 January 2008Published online15 February 2008Published inissue 1 February 2008https://pubs.acs.org/doi/10.1021/cb800019ghttps://doi.org/10.1021/cb800019gnewsACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views171Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cancer,Carbohydrates,Genetics,Peptides and proteins,Viruses Get e-Alerts
Coexistence of ferromagnetic and superconducting domains in Co-doped BaFe 2 As 2 superconductors probed using infrared Faraday measurements (2019)

We explore the electronic and magnetic properties of superconducting iron pnictide films by probing their infrared Hall conductivity as a function of probe energy (0.1-1.3 eV), temperature (10-300 K) and magnetic field (B = 0-7 T). We find hysteretic behavior in the complex infrared Faraday angle, $\theta_{F}$, at lowB over the entire temperature range. At higher $B, \theta_{\mathrm{F}}$ is linear in B and we observe a peak in the high B -field slope near 50 K, which may be related to the superconducting phase of the films.
Organic Field-Effect Transistors Based on a Liquid-Crystalline Polymeric Semiconductor using SU-8 Gate Dielectrics on (2014)

In this work, the insulating properties of poly(4-vinylphenol) (PVP) and SU-8 (MicroChem, Westborough, MA, USA) dielectrics are analyzed and compared with each other. We further investigate the performance behavior of organic field-effect transistors based on a semiconducting liquid-crystal polymer (LCP) using both dielectric materials and evaluate the results regarding the processability. Due to the lower process temperature needed for the SU-8 deposition, the realization of organic transistors on flexible substrates is demonstrated showing comparable charge carrier mobilities to devices using PVP on glass. In addition, a -dispensing procedure of the LCP on SU-8 is presented, improving the switching behavior of the organic transistors, and the promising stability data of the SU-8/LCP stack are verified after storing the structures for 60 days in ambient air showing negligible irreversible degradation of the organic semiconductor.
A Common Transcriptional Activator Is Located in the Coding Region of Two Replication-Dependent Mouse Histone Genes (1991)

There is a region in the mouse histone H3 gene protein-encoding sequence required for high expression. The 110-nucleotide coding region activating sequence (CRAS) from codons 58 to 93 of the H3.2 gene restored expression when placed 520 nucleotides 5' of the start of transcription in the correct orientation. Since identical mRNA molecules are produced by transcription of the original deletion gene and the deletion gene with the CRAS at -520, effects of the deletions on mRNA stability or other posttranscriptional events are completely ruled out. Inversion of the CRAS sequence in its proper position in the H3 gene resulted in only a threefold increase in expression, and placing the CRAS sequence 5' of the deleted gene in the wrong orientation had no effect on expression. In-frame deletions in the coding region of an H2a.2 gene led to identification of a 105-nucleotide sequence in the coding region between amino acids 50 and 85 necessary for high expression of the gene. Additionally, insertion of the H3 CRAS into the deleted region of the H2a.2 gene restored expression of the H2a gene. Thus, the CRAS element has an orientation-dependent, position-independent effect. Gel mobility shift competition studies indicate that the same proteins interact with both the H3 and H2a CRAS elements, suggesting that a common factor is involved in expression of histone genes.
Mouse Adipose-Derived Stem Cells Undergo Multilineage Differentiation in Vitro but Primarily Osteogenic and Chondrogenic Differentiation in Vivo (2006)

Human, rat, and mouse studies have demonstrated the existence of a population of adipose-derived adult stem (ADAS) cells that can undergo multilineage differentiation in vitro.However, it remains unclear whether these cells maintain their multilineage potential in vivo.The aim of this study was to examine the in vitro and in vivo characteristics and behavior of a potential population of murine ADAS (muADAS) cells isolated from the visceral fat of the abdominal cavity of C57BL/10J mice.We used flow cytometry to examine the cells' expression of CD29, CD31, CD45, CD34, CD44, CD144, CD146, Flk1, and Sca-1.The isolated cell population was CD45 negative, which precludes contamination by hematopoietic cells, but was partially positive for Sca-1 and CD34: 2 stem-cell markers.After induction in conditioned medium, the muADAS cells gained the ability to undergo adipogenic, osteogenic, chondrogenic, myogenic, and hematopoietic differentiation in vitro.The muADAS cells readily differentiated to form bone and cartilage in vivo for up to 24 weeks, but their ability to regenerate muscle or reconstitute bone marrow was found to be limited.
Increased beat-to-beat T-wave variability in myocardial infarction patients (2016)

The purpose of this study was to investigate the beat-to-beat variability of T-waves (TWV) and to assess the diagnostic capabilities of T-wave-based features for myocardial infarction (MI). A total of 148 recordings of standard 12-lead electrocardiograms (ECGs) from 79 MI patients (22 females, mean age 63±12 years; 57 males, mean age 57±10 years) and 69 recordings from healthy subjects (HS) (17 females, 42±18 years; 52 males, 40±13 years) were studied. For the quantification of beat-to-beat QT intervals in ECG signal, a template-matching algorithm was applied. To study the T-waves beat-to-beat, we measured the angle between T-wave max and T-wave end with respect to Q-wave (∠α) and T-wave amplitudes. We computed the standard deviation (SD) of beat-to-beat T-wave features and QT intervals as markers of variability in T-waves and QT intervals, respectively, for both patients and HS. Moreover, we investigated the differences in the studied features based on gender and age for both groups. Significantly increased TWV and QT interval variability (QTV) were found in MI patients compared to HS (p<0.05). No significant differences were observed based on gender or age. TWV may have some diagnostic attributes that may facilitate identifying patients with MI. In addition, the proposed beat-to-beat angle variability was found to be independent of heart rate variations. Moreover, the proposed feature seems to have higher sensitivity than previously reported feature (QT interval and T-wave amplitude) variability for identifying patients with MI.
Carinata Production in Florida (2014)

Brassica carinata is a promising oilseed crop with great potential for profitable cultivation in Florida. Its high oil content and favorable fatty acid profile make it suitable for the biofuel industry, especially as a biojet fuel. The UF/IFAS North Florida Research and Education Center (NFREC) in Quincy, Florida, has been working to identify advanced carinata genotypes that are high yielding (seed and oil), disease resistant, early maturing, and adapted to Florida. The work at NFREC is being done in conjunction with Agrisoma Biosciences Inc., a crop company that has the world’s largest collection of carinata germplasm. This 6-page fact sheet’s “Agronomic Management” section provides recommendations resulting from NFREC’s research. It was written by C. M. Bliss, R. Seepaul, D. L. Wright, J. J. Marois, R. Leon, N. Dufault, S. George, and S. M. Olson, and published by the UF Department of Agronomy, December 2014. SS-AGR-384/AG389: Carinata, the Sustainable Crop for a Bio-based Economy: 2018–2019 Production Recommendations for the Southeastern United States (ufl.edu)
Self-Assembling Properties of Membrane-Modifying Peptides Studied by PELDOR and CW-ESR Spectroscopies (2000)

A new technique is described that is suitable to determine the formation of aggregates from monomeric biomolecules. This technique has been tested in the study of the self-assembling properties of the antibiotic trichogin GA IV which belongs to the class of peptaibols. We have investigated the self-assembling properties of three trichogin analogues by pulsed double resonance in electron spin-echo (PELDOR) spectroscopy combined with conventional continuous wave ESR spectroscopy. In the peptides examined Aib has been substituted by its spin-labeled analogue TOAC at three specific positions of the sequence. More specifically, the magnetic dipole-dipole relaxation of the spin-labeled peptides is measured in glassy polar and apolar solvents at 77 K. Specific assemblies of trichogin molecules are formed in an apolar solvent but addition of a more polar solvent leads to dissociation of the aggregates, The estimates based on experimental data show that each aggregate cluster contains four peptide molecules, Some of the distances between spin labels in the cluster have been determined. In addition, CW-ESR data suggest the occurrence of aggregated species in the same solutions at room temperature. The experimental results are consistent with a model wherein four amphiphilic helical peptide molecules form a vesicular system with the polar amino acid side chains pointing to the interior and the apolar side chains to the exterior of the cluster.
A 2.5 gigabit 23-mile radio link for LuckyNet (2002)

The factors which affect the choice of the LuckyNet radio link design, involving data rates on the order of 2.5 Gb/s, are discussed. The specific design of the 2.5-Gb/s radio link for the 23-mile path between the Murray Hill and Crawford Hill locations of AT&T Bell Laboratories is described, along with preliminary performance results. The propagation factors which have the dominant effect on link availability are fading due to rain, water vapor, and multipath. Less than 10/sup -11/ bit error rate (BER) is achieved with an estimated availability of about 95%/yr. The link provides 2.5 b/s/Hz of bandwidth by using dual polarization and QPSK modulation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Glucose-induced insulin release (1995)

info:eu-repo/semantics/published
A streamlined modeling workflow to obtain subject-specific musculoskeletal models of lower extremity based on MRI scan and dynamometry (2013)

Gastroenterological oncology requires new strategies with new mechanisms of action and without cross-resistance to currently available treatment regimes. Virotherapy which is based on the employment of replication-competent viral vectors exhibiting strong oncolytic properties is such an approach currently under preclinical/clinical investigation. Techniques of molecular virology are required for further improvement of current vectors, particularly with respect to oncolytic activity, tumour selectivity, tumour spread capacity, and safety.
Chemical Studies of Structural Features in Staphylococcal Nuclease-T′ (1972)

Abstract Synthetically and chemically modified forms of staphylococcal nuclease-T', the noncovalent complex of the polypeptide fragments nuclease-T-(6–48) (containing residues 6 through 48 of staphylococcal nuclease) and nuclease-T-(49–149) (containing residues 49 through 149 of nuclease), were prepared and characterized. Analogue forms of synthetic-(6–47) (the synthetic fragment corresponding to nuclease residues 6 through 47) were prepared by the solid phase method with variations from the normal sequence at residues lysine 9, glutamic acid 10, proline 11, alanine 12, threonine 13, leucine 14, isoleucine 15, isoleucine 18, and tyrosine 27. In addition, [3-nitro-l-tyrosyl 27]-nuclease-T-(6–48) and [3-amino-l-tyrosyl 27]-nuclease-T-(6–48) were obtained, respectively, by tetranitromethane treatment of nuclease-T-(6–48) and by subsequent reduction of the nitrated product. All of the above fragment derivatives were studied for the ability to associate with nuclease-T-(49–149) to generate enzymic activity. The results have allowed a description of the functions of the residues studied in nuclease-T'. This information has been interpreted further based on the present knowledge of the staphylococcal nuclease crystal structure (Arnone, A., Bier, C. J., Cotton, F. A., Hazen, E. E., Jr., Richardson, D. C., Richardson, J. S., AND Yonath, A. (1971) J. Biol. Chem. 246, 2302) and therein extended to predictions for intact nuclease as well. The studies reported indicate that the NH2-terminal residues 9 through 13 participate in several critical main chain and side chain hydrogen bonds, with loss of residues 6 through 13 causing complete destabilization of the nuclease-T' complex. Tyrosine 27 helps to stabilize nuclease-T' structure, probably by hydrophobic interactions as well as by side chain hydrogen bonding, whereas the nonpolar side chains of isoleucine 15 and isoleucine 18 are important for nuclease-T' fragment association and stabilization of the active site region of the complex, respectively. The results are consistent with the view that nuclease and nuclease-T' have similar detailed structural features in the regions studied.
Evaluation of Patients with Previous Coronary Stent Implantation with 64-Section CT (2007)

In selected patients with previous stent implantation, 64-section CT can be used to evaluate in-stent restenosis with high accuracy. Accordingly, the technique may be useful for noninvasive exclusion of in-stent or peristent restenosis, thereby avoiding invasive imaging in a considerable number of patients.
Prostaglandin F2 alpha stimulates proliferation of clonal osteoblastic MC3T3-E1 cells by up-regulation of insulin-like growth factor I receptors. (1991)

Prostaglandin F2 alpha (PGF2 alpha) stimulates proliferation of clonal osteoblastic MC3T3-E1 cells mainly via the stimulation of phospholipase C. These cells constitutively produced and secreted insulin-like growth factor I (IGF-I). In addition, a neutralizing anti-IGF-I antibody completely abolished DNA synthesis stimulated by PGF2 alpha in MC3T3-E1 cells, suggesting that IGF-I indeed mediates the PGF2 alpha effect. However, PGF2 alpha decreased the expression of IGF-I mRNA and the secretion of immunoreactive IGF-I into the medium, whereas progression activity in the conditioned medium was not affected by PGF2 alpha. Although IGF-I alone did not stimulate DNA synthesis in MC3T3-E1 cells, when PGF2 alpha was added to the cultures, IGF-I stimulated their proliferation. Thus, PGF2 alpha may potentiate the action of IGF-I. At the same time, PGF2 alpha increased the number of high affinity binding sites (molecular mass of 130 kDa) for IGF-I in a dose-dependent manner. The increase in IGF-I-binding site number preceded the elevation of DNA synthesis by approximately 3 h. Furthermore, MC3T3-E1 cells secreted at least three species of IGF-binding proteins (IGFBPs) with molecular masses of 24, 30, and 34 kDa. In the early period of PGF2 alpha exposure, PGF2 alpha attenuated the secretion of all of these IGFBPs, whereas thereafter, it markedly increased their secretion, especially that of the 34-kDa IGFBP, suggesting a modulation of metabolism and action of IGF-I. These effects of PGF2 alpha on IGF-I receptor number and IGFBP secretion may play a role in the synergism between PGF2 alpha and IGF-I that results in the stimulation of DNA synthesis in MC3T3-E1 cells.
A phase I trial on LBH589 (panobinostat), a histone deacetylase inhibitor in combination with external radiotherapy for the treatment of prostate cancer, oesophageal cancer and head and neck cancer: protocol CLBH589CBE01 (2010)

peer reviewed
EFFECTS OF MIXING SOYBEAN FLOUR DOUGHS ON THEIR DYNAMIC MODULI MEASURED IN AN ORTHOGONAL RHEOMETER (1984)

ABSTRACT An orthogonal rheometer was used to determine the dynamic loss moduli and storage moduli of defatted soybean flour doughs. Doughs of 30 to 50% moisture were prepared by mixing for 1 to 10 min in a Brabender laboratory mixing head. Both moduli decreased as dough moisture increased. Moduli increased as mixing time increased. Moduli were initially constant as percent strain increased. After 1 1/2% strain, moduli decreased with increasing strain. No effect of resting time was found.