gebhart/patrepeval huggingface dataset:
Ab initio protein modelling reveals novel human MIT domains (2009)

Database searches can fail to detect all truly homologous sequences, particularly when dealing with short, highly sequence diverse protein families. Here, using microtubule interacting and transport (MIT) domains as an example, we have applied an approach of profile-profile matching followed by ab initio structure modelling to the detection of true homologues in the borderline significant zone of database searches. Novel MIT domains were confidently identified in USP54, containing an apparently inactive ubiquitin carboxyl-terminal hydrolase domain, a katanin-like ATPase KATNAL1, and an uncharacterized protein containing a VPS9 domain. As a proof of principle, we have confirmed the novel MIT annotation for USP54 by in vitro profiling of binding to CHMP proteins.
The PD-1/PD-L1 pathway in advanced prostate cancer—have we milked this cow? (2019)

We would like to thank Dr. Fay and Dr. Antonarakis for their insightful comments on immunotherapy (IO) in advanced prostate cancer and specifically their commentary on the recently published KEYNOTE-028 study on the use of pembrolizumab in programmed cell death protein-1 ligand (PD-L1) positive metastatic castrate resistant prostate cancer (mCRPC) (1). As described by the authors, monotherapy with checkpoint inhibitors has not demonstrated the dramatic response rates in mCRPC that were shown in other cancer types such as melanoma and non-small cell lung cancer (NSCLC).
Thrombopoietin (1997)

The regulator of platelet count is believed to be thrombopoietin (mpl ligand). It is thought to act on the megakaryocytic lineage affecting the proliferation of committed cells, the maturation of megakaryocytes and the blood platelet levels by activation of its receptor (the c-mpl). Recently, it has been purified and sequenced. Thrombopoietin offers potential applications for treatment of thrombocytopenia.
Psidium guajava: A review on its potential as an adjunct in treating periodontal disease (2014)

Plants for thousands of years have been used to enhance health and for medicinal purposes. Psidium guajava is one which has an enormous wealth of medicinal value. It for long has been known for its anti-inflammatory, antimicrobial, antioxidant, antidiarrheal, antimutagenic properties. Despite of its widespread biologic uses there is a dearth of information on its therapeutic effect in the treatment of periodontal disease. Hence, this review is an attempt to highlight the potential of P. guajava in the treatment of periodontal disease. Internet databases PubMed, Google Scholar were searched and the most relevant articles were considered for review.
Air travel for the chronically ill and the elderly. (1983)

The cabin altitude during airline flights is usually 1,500 m (5,000 ft). Medically important factors include the decreased bioavailability of oxygen, the dryness of the air and the properties of gases within the body as stated in Boyle's law. Passengers who are physically compromised by chronic disease, advanced age or mobility impairment can usually have their special requirements met through the cooperation of the family physician and the airline. Special diets, supplemental oxygen, locomotive aids and communication services are provided on advanced request.
The effects of brace position on injuries sustained in the M1 Boeing 737/400 disaster, January 1989. NLDB Study Group. (1993)

Of the initial 87 survivors of the East Midlands Boeing 737/400 aircraft, 77 sustained head and facial trauma during the crash, 45 of whom were rendered unconscious. There were 21 who received injuries to the back of their head, including 5 of the 6 severely head-injured adults. Those passengers who adopted the fully flexed "brace" position for crash-landing achieved significant protection against head injury, concussion, and injuries from behind irrespective of local aircraft structural damage. A computer graphics simulation developed by a commercial firm (H. W. Structures, Ltd.) using the predicted crash pulse of the accident has validated these clinical findings and allows theoretical biomechanical modeling for the design of occupant protection systems in the future. Although the major role of structural failure should not be forgotten, bracing maximizes the chance of uninjured survival in the current generation of aircraft and should be demonstrated and practiced as a pre-flight routine.
Studies Regarding the Safety in Operation of Ezer Reservoir (2014)

Abstract The dam of the non-permanent reservoir Ezer, located on Jijia river is an earth dam with a maximum height of 6.18 m, which provides a global retention to the canopy of 10.330 million cubic meters. The dam founded on weak, muddy soils suffered in the years 1989 and 1992 downstream slope failures of the fillings. It was found that hydrostatic levels were high in the piezometric wells and that consolidation of the foundation soil was reduced. This paper presents a brief history of the dam and aspects regarding the behaviour monitoring of Ezer non-permanent reservoir during the years 2000-2012.
Repeatability and Reproducibility of Germicide Tests: A Literature Review (1999)

The results of a quantitative antimicrobial assay can be summarized by the log reduction value. For an assay to be proposed as a standard method, it is usually necessary to conduct a collaborative study to demonstrate that the repeatability and reproducibility standard deviations (SDs) of the log reduction values are sufficiently small. It is not clear, however, precisely how small those SDs should be. This paper describes the results of a literature review conducted to determine the range of repeatability and reproducibility SDs for standard quantitative antimicrobial assays. The underlying premise is that, for an assay to have been accepted as a standard method, its repeatability and reproducibility SDs must have been sufficiently small. This premise implies that the repeatability and reproducibility SDs of standard assays establish de facto guidelines for acceptability. The survey comprised papers where the SDs could be extracted directly or where they could be calculated from accessible data. Papers describing suspension tests as well as hard surface tests were included. For the standard antimicrobial assays reviewed, repeatability SDs ranged from 0.25 to 1.21 and the reproducibility SDs ranged from 0.31 to 1.54.
Compact and user-friendly representation of IPv6 addressing approach and masking (2009)

This paper presents a friendly representation of currently implemented IPv6 address and proposes a more compact and end-user friendly format for IT professionals. It has been evaluated that the next generation IPv6 address would not only facilitate network professionals but also be used by all communities. IPv6 will also be employed on objects other than communication devices for tracking and remote administration viz. household electronic devices, mobile devices and even assign Human beings to track them. Considering the fact that it would be harder to remember 32 characters long IPv6 address separated by colons by humans like remembering telephone numbers, this paper presents an alpha-numeric IPv6 address Masking which contains 0-9, a-z, A-Z, . (dot) and - (Hyphen) using base64 number system. Total length of address reduces from 39 characters (32 + 7 colons) to the maximum of 22 characters that is approximately 56% (22/39*100). The proposed 22 characters address which is a user-friendly address could be further compressed by using ¿6 5 4 rule¿ which has also been proposed in this paper.
Cultivation of marine shrimp in biofloc technology (BFT) system under different water alkalinities (2015)

The aim of this study was to evaluate the influence of different levels of alkalinity for the superintensive cultivation of marine shrimp Litopenaeus vannamei in biofloc system. A total of 12 experimental circular units of 1000L were used supplied with 850L water from a nursery, populated at a density of 165 shrimps.m-3 and average weight of 5.6 g. The treatments, in triplicate, consisted in four levels of alkalinity in the water: 40, 80, 120 and 160 mg.L-1 of calcium carbonate. To correct the alkalinity was used calcium hydroxide (CaOH). It was observed a decrease in pH of the water in the treatments with lower alkalinity (p<0.05). The total suspended settleable solids were also lower in the treatment of low alkalinity. No significant difference was observed in other physico-chemical and biological parameters in the water quality assessed, as well as the zootechnical parameters of cultivation between treatments (p≥0.05). The results of survival and growth rate of shrimps were considered suitable for the cultivation system used in the different treatments. The cultivation of marine shrimp Litopenaeus vannamei in biofloc at density of 165 shrimps.m-3 can be performed in waters with alkalinity between 40 and 160 mg.L-1 of CaCO3, without compromising the zootechnical indexes of cultivation.
Clinical correlations of the 3q21;q26 cytogenetic anomaly. A leukemic or myelodysplastic syndrome with preserved or increased platelet production and lack of response to cytotoxic drug therapy (1985)

Three patients presenting with acute leukemic disorder and chromosome 3 rearrangement involving bands q21;q26 are reported, and the literature on chromosome 3q abnormalities is reviewed. All reported patients carrying a paracentric 3q inversion or a translocation 3;3 with breakpoints in q21;q26 had a myelodysplastic or acute leukemic disorder with a normal or elevated platelet count and lack of response to cytotoxic drug therapy. They showed an associated incidence of -7 or 7q- anomalies higher than de novo acute leukemia and appear to constitute a definite subgroup of the leukemic disorders with very poor prognosis. The majority of patients showing other chromosome 3 long arm rearrangements showed evidence of leukemic process, were in blastic crisis, or had been exposed to chemotherapy, exhibiting also a higher incidence of associated -5 or -7 cytogenetic abnormalities than is observed in patients not exposed to toxic agents.
Specific-heat evidence of strong electron correlations and thermoelectric properties of the ferromagnetic perovskite<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi mathvariant="normal">Sr</mml:mi><mml:mi mathvariant="normal">Co</mml:mi><mml:msub><mml:mi mathvariant="normal">O</mml:mi><mml:mrow><mml:mn>3</mml:mn><mml:mo>−</mml:mo><mml:mi>δ</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> (2006)

A dense pellet of the polycrystalline $\mathrm{Sr}\mathrm{Co}{\mathrm{O}}_{3\ensuremath{-}\ensuremath{\delta}}$ $(0\ensuremath{\leqslant}\ensuremath{\delta}<0.2)$ was obtained by a high-pressure method, and electronic transport properties of the stoichiometric perovskite were measured. A large electronic specific-heat coefficient was found $[45.7(2)\phantom{\rule{0.3em}{0ex}}\mathrm{mJ}\phantom{\rule{0.2em}{0ex}}{\mathrm{mol}}^{\ensuremath{-}1}\phantom{\rule{0.2em}{0ex}}{\mathrm{K}}^{\ensuremath{-}2}]$, indicating a moderate degree of electrons correlation: the mass enhancement factor was 6.1, which is higher than that for the $4d$ ferromagnetic perovskite $\mathrm{Sr}\mathrm{Ru}{\mathrm{O}}_{3}$ (4.4). The thermoelectric properties of $\mathrm{Sr}\mathrm{Co}{\mathrm{O}}_{3}$ were found to be sensitive to band filling, in contrast to those of $\mathrm{Sr}\mathrm{Ru}{\mathrm{O}}_{3}$.
Effects of Actuating Pressure Waveforms on the Droplet Behavior in a Piezoelectric Inkjet (2010)

This paper presents a numerical analysis of a piezoelectric actuated droplet generator. A three-dimensional finite difference numerical model based on a SOLA (solution algorithm) scheme for the solution of governing equations of the flow field and a volume-of-fluid method for tracing the fluid interfaces are presented. The surface tension is modeled using a continuum surface force concept and thus computed as a function of the interfacial curvature. The pressure pulse at the nozzle inlet, which is related to the applied voltage, was imposed according to the propagation theory of acoustic waves. The effects of the pressure waveforms, including positive and negative pressure amplitudes, operating period and acceleration of the positive pressure, on the droplet ejection process are simulated. The performance of piezoelectric inkjet: droplet break time, droplet tail length, droplet velocity and droplet volume are analyzed. The simulation results show that the tail length and volume of the droplet increase with the amplitude of the positive pressure and operating period. The breakup time of the droplet is shorter when the amplitude of the negative pressure increases. The factors that influence satellite droplets are also investigated in this study.
Contesting contestation: Global social policy prescriptions on pensions and health systems (2013)

This article discusses the conceptualization of global social policy in its dimension of prescriptions on national social policy. By studying the global health systems discourse and comparing it to the discourse on pensions, the applicability and validity of common notions of contestation and struggle between global social policy actors and their ideas are discussed. On the basis of conceptual considerations on global social policy ideas and discourses, the reasons for the differences between the two discourses are elaborated on. The article offers conclusions as to the conceptualization of global social policy prescriptions with regard to notions of the ‘war of positions’ and the promises of the ASID (agency, structure, institution, discourse) framework.
Effect of Vitamin B12 on Wound Healing (1953)

1) These data show that B12 increased the tensile strength of wounds during the early phases of healing in rats fed balanced diets containing 19% or 25% protein. This effect was evident at least by the third day in the wounds studied, and it was most noticeable by the sixth day. 2) The wound's that were studied in the saline control and vitamin treated rats from the third to the eighth day showed no significant diffemnce in their healing rates at the eighth day. 3) The delayed healing rate and increased incidence of wound infection in rats that were protein depleted by, diet were not signifioantly altered by administration of vit. B12.
Isolation of Labile Multi-protein Complexes by <em>in vivo</em> Controlled Cellular Cross-Linking and Immuno-magnetic Affinity Chromatography (2010)

The dynamic nature of cellular machineries is frequently built on transient and/or weak protein associations. These low affinity interactions preclude stringent methods for the isolation and identification of protein networks around a protein of interest. The use of chemical crosslinkers allows the selective stabilization of labile interactions, thus bypassing biochemical limitations for purification. Here we present a protocol amenable for cells in culture that uses a homobifunctional crosslinker with a spacer arm of 12 A, dithiobis-(succinimidyl proprionate) (DSP). DSP is cleaved by reduction of a disulphide bond present in the molecule. Cross-linking combined with immunoaffinity chromatography of proteins of interest with magnetic beads allows the isolation of protein complexes that otherwise would not withstand purification. This protocol is compatible with regular western blot techniques and it can be scaled up for protein identification by mass spectrometry.
Herpes simplex and varicella-zoster infections: clinical and laboratory diagnosis. (2004)

One of a dentist's most common diagnostic challenges is determining the cause of vesiculo-ulcerative disorders of the oral cavity. The most common etiology of oral vesicles is herpes simplex virus (HSV) infection. Varicella-zoster virus (VZV) is a less common etiology of vesicles in the oral cavity. Dentists often are able to differentiate these two viruses based on the clinical presentation of infectious symptoms; however, further laboratory testing is required to identify herpetically induced vesiculo-ulcerative lesions definitively. This article reviews the basic clinical signs and symptoms of HSV and VZV infection and describes the various laboratory tests that can determine the definitive etiology of the vesiculo-ulcerative disorder.
Serial bideposition of anisotropic thin films with enhanced linear birefringence (1999)

We describe a serial bideposition technique in which a tilted substrate is rotated stepwise by half a turn about a normal axis during the evaporation of a metal oxide from a single electron-beam source. Coatings formed by the new method develop a columnar nanostructure that is perpendicular to the substrate and has greatest width or bunching perpendicular to the common deposition plane. With appropriate choice of deposition parameters, the method produces biaxial films with large birefringence, principal axes aligned parallel and perpendicular to the substrate, and improved uniformity. Measured phase retardances for light incident normally on the films are double the corresponding values for tilted-columnar films.
Fonction et représentation de la bourgeoisie dans les beaux-arts au siècle des Lumières (1980)

info:eu-repo/semantics/published
Marketing digital: una mirada al pasado, presente y futuro (2016)

The evolution of marketing has undoubtedly been a frantic race of constant change since its inception; however, today's society is witnessing an unprecedented revolution in the forms of relationship of the organization with its markets, thanks mainly to the integration of technology advances and adoption society makes this same. Globalization and increased competition, the differential factor of products, the search for competitive advantage, increasing consumer demands and constant changes in the legal regulation, are some of the factors that are making the change a imperative challenge for companies in search of leading customer segments, position their brands and establish a link with consumers that guarantee sustainability in the long-term market. As explained, this article aims to analyze the digital marketing under a perspective of the past, present and future; be given a brief tour of what has been the trajectory of digital marketing, from its generation as a discipline and business models, to the incursion of online marketing, including the adoption of what is now known as mobile marketing in that sense. Keywords: digital marketing, online marketing, mobile marketing, globalization, technology.
Modeling Off-Nominal Recovery in NextGen Terminal-Area Operations (2011)

Robust schedule-based arrival management requires efficient recovery from off-nominal situations. This paper presents research on modeling off-nominal situations and plans for recovering from them using TRAC, a route/airspace design, fast-time simulation, and analysis tool for studying NextGen trajectory-based operations. The paper provides an overview of a schedule-based arrival-management concept and supporting controller tools, then describes TRAC implementations of methods for constructing off-nominal scenarios, generating trajectory options to meet scheduling constraints, and automatically producing recovery plans.
Effectiveness of Multiple Internal Standards: Deuterated Analogues of Methylenedioxymethamphetamine, Methylenedioxyamphetamine, Methamphetamine, and Amphetamine (2004)

With the increasing abuse of methylenedioxymethamphetamine (MDMA) thereby requiring analysis, we have undertaken a systematic evaluation on parameters associated with the analysis of MDMA and related compounds, including methylenedioxyamphetamine (MDA), methamphetamine (MA), and amphetamine (AM). Parameters studied included three solid-phase adsorbents, five derivatization reagents, and four deuterated internal standards (IS). This report examines whether differences in quantitation data derived from the use of four ISs (one for each analyte) and two ISs (one for AM and MA, one for MDA and MDMA) are statistically significant. Two types of samples were included in this study. The first type (Type I) included four replicate sets of standard solutions prepared in urine matrix. All analytes (AM, MA, MDA, and MDMA) were included in all samples, and these analytes' concentrations in each set were at five levels (100, 250, 500, 1000, and 2000 ng/mL). Four deuterated analogues (MA-d(8), AM-d(8), MDMA-d(5), and MDA-d(5)) at 500 ng/mL were also included in all solutions. The second type of samples (Type II) included 25 case urine specimens. Most of these specimens contained MA/AM and/or MDMA/MDA. The specific objective of this study is to determine whether the 4-IS approach can indeed generate better quantitative data than a less-costly 2-IS. For Type I samples, where the true concentrations of the analytes are known, two-sample t-test is adapted to examine whether the two sets of prediction errors (i.e., known concentration minus calculated concentration) resulting from the 4-IS and the 2-IS approaches are statistically different. For Type II samples, where the analytes' true concentrations are unknown, one-sample t-test was adapted to determine whether the difference of the quantitation results derived from the 4-IS and the 2-IS approaches is statistically significant. Statistical analysis of quantitation data derived from Types I and II samples indicates that differences in MDA and MDMA concentrations resulting from the use of one (MDA-d(5) or MDMA-d(5)) or two (MDA-d(5) and MDMA-d(5)) are statistically nonsignificant. On the other hand, similar analysis on data derived from Type I samples indicate the use of the analytes' respective deuterated analogues as the ISs appear to generate better quantitative data for AM and MA.
The Fish Traps at Brewarrina, N.S.W. (Cover Drawing by Billy Reid) (1983)

A series of hand-built stone walls or weirs are stretched across the Darling River in north western New South Wales called the 'Gurrungga'. These provide a reliable source of fish for the people who worked the traps.
ChemInform Abstract: REACTIONS OF 2‐PIVALOYLPYRIDINE WITH PALLADIUM(II) ACETATE RESULTING IN THE FORMATION OF (1‐METHOXY‐ AND 1‐HYDROXY‐2,2‐DIMETHYL‐1‐(2‐PYRIDYL)PROPOXO‐N,O)PALLADIUM(II) COMPLEXES (1985)

Abstract Die Titelreaktion liefert in MeOH (1 h Rückfluß) den Komplex (Ia), der durch IR‐ und ′3C ′H ‐NMR‐Daten charakterisiert wurde und als Gemisch von zwei Diastereomeren, racemischer und meso‐Form (Verhältnis etwa 3 : l) vorliegt.
Applications of multivariate statistical methods to process monitoring and controller design (1994)

Abstract Novel ways of using multivariate statistical methods to develop process models for on-line monitoring and control are proposed. On a binary distillation column, PLS is used to develop a regression estimation using multiple tray temperature measurements and a manipulated variable to estimate and control distillate composition. Additionally, a feedback controller design based on a static PCA/PCR model is developed and demonstrated on the binary column. This controller's performance is compared with a PI controller for disturbance rejection and setpoint tracking. On a real-world chemical process, it is shown how both PLS and PCS are necessary to model normal plant operations. These models permit real-time monitoring and detection in a reduced subspace defined by the statistical independent variations in the data. Techniques for real-time monitoring and fault detection are demonstrated.