gebhart/patrepeval huggingface dataset:
Environmental biotechnology: its relevance, challenges and prospect for developing countries (2004)

Abstract This paper describes the relevance. challenges and prospects of environmental biotechnology for developing countries. with Special emphasis on Malaysia. The subject has been introduced at graduate level in many universities to foster a multidisciplinary approach for training a new generation of environmental scientists and engineers. Environmental biotechnology has been widely utilized to improve our understanding of microbial population. its character, prominent species and genetic codes, and the techniques are also applied in process control and optimization of waste treatment plants. polluted site remediation and resource recovery. Once an expensive and largely unfamiliar option, it has now become a realistic alternative to many established approaches in manufacturing. remediation, pollution control and waste management. Recent developments in biotechnology has opened up numerous challenges and opportunities to the research community and the practitioners. These include development of simple molecular procedures, more reliable usage as biosensors and bioinformatics for environmental control and management. These challenges, coupled with recent developments in information technology. materials science, nanotechnology and microelectronics will surely enhance the state-of-the-art technologies in water and waste management problems.
Methylation-Associated Gene Silencing of<i>RARB</i>in Areca Carcinogens Induced Mouse Oral Squamous Cell Carcinoma (2014)

Regarding oral squamous cell carcinoma (OSCC) development, chewing areca is known to be a strong risk factor in many Asian cultures. Therefore, we established an OSCC induced mouse model by 4-nitroquinoline-1-oxide (4-NQO), or arecoline, or both treatments, respectively. These are the main two components of the areca nut that could increase the occurrence of OSCC. We examined the effects with the noncommercial MCGI (mouse CpG islands) microarray for genome-wide screening the DNA methylation aberrant in induced OSCC mice. The microarray results showed 34 hypermethylated genes in 4-NQO plus arecoline induced OSCC mice tongue tissues. The examinations also used methylation-specific polymerase chain reaction (MS-PCR) and bisulfite sequencing to realize the methylation pattern in collected mouse tongue tissues and human OSCC cell lines of different grades, respectively. These results showed that retinoic acid receptor β (RARB) was indicated in hypermethylation at the promoter region and the loss of expression during cancer development. According to the results of real-time PCR, it was shown that de novo DNA methyltransferases were involved in gene epigenetic alternations of OSCC. Collectively, our results showed that RARB hypermethylation was involved in the areca-associated oral carcinogenesis.
Laser-induced photopatterning of organic–inorganic TiO2-based hybrid materials with tunable interfacial electron transfer (2009)

Hybrid organic-inorganic materials based on TiO(2) gels demonstrate high photosensitivity. Associated with their stable photochromic behavior, these make them suitable for laser-induced photopatterning. We show that the electronic coupling along the extended interface between the inorganic, TiO(2)-based gel, and the organic, poly(hydroxyethyl methacrylate) networks allows (i) a rapid scavenging of the photo-excited holes by the polymer, (ii) an efficient trapping of the photo-exited electrons as small polarons (Ti(3+)) that develop "dark" absorption continuum covering the spectral range from 350 nm (UV) to 2.5 microm (IR), and (iii) long-term (over months) conservation of trapped charges at high number density. Furthermore, we give the proof that the electron transfer depends on the material microstructure, which can be affected by the material chemistry and processing. Undeniably, a delay between the gelation of the system and the organic polymerization step allows tuning the photochromic responses of the resulting nanocomposites. A comparison is made between the prepared gel-based samples and a reference sample, which is obtained by the organic copolymerization of functional precondensed inorganic building units, titanium oxo-clusters, Ti(16)O(16)(OEt)(24)(OEMA)(8) with hydroxyethyl methacrylate. The experiments show the highest values of quantum yield (12%) and Ti(3+) concentration (1.7 x 10(20) cm(-3) or 14% of titanium atoms) attained in samples where the organic polymerization is induced after gelation. This behavior is explained by a strong coupling between the organic and the inorganic components of the hybrid towards the hole exchange and a poor coupling towards the electron exchange.
[Incidence of diabetes mellitus in patients with malignant tumors of the oral cavity]. (2002)

Diabetes mellitus affects 5% of the population of Hungary. Its complications in the oral cavity include parodontosis and changes in the oral mucosa (leukoplakia, lichen oris and glossitis). The incidence of leukoplakia (the most frequent precancerous state in the oral cavity) is 2.2% in the normal population, 6.2% among diabetics, and 11.5% among diabetic who smoke. The various forms of leukoplakia in the oral cavity become malignant in 5-20% of the cases, while the erosive, ulcerative lesions do so in 15-20% of the cases. These data led us to examine the blood glucose levels in 318 patients with histologically confirmed malignant tumours in the oral cavity. Diabetes mellitus was found in 56 of them (17.5%), the blood glucose level being elevated in 31 cases (9.75%). The fact that the incidence of diabetes mellitus among these patients was more than 3 times higher than that for the normal population demonstrates that further studies should be performed on the connection between diabetes mellitus and malignant tumours in the oral cavity.
[Effects of PprI and RecX on antioxidant activity of Deinococcus radiodurans]. (2006)

Effects of mutations of Pprl (Dr0167) and RecX (Dr1310), which are relative to radioresistance, on reactive oxygen species scavenging activities in Deinococcus radiodurans were investigated using gene mutation, chemiluminescence measurement and enzyme activity analysis. Their possible regulating functions on the activities of antioxidant enzymes was evaluated. Results show that mutant that lacks PprI is remarkably sensitive to reactive oxygen species and its enzyme activities of catalase and superoxide dismutase decrease significantly. On the other hand, RecX has a "negative" effect on reactive oxygen species scavenging activities of this bacterium, i.e., mutation of recX enhances the scavenging activities on reactive oxygen species, and the enzyme activities of catalase and superoxide dismutase in mutant that lacks RecX are significantly increased. These results indicate that these two genes are relative to the regulation of antioxidant system of this bacterium. It presents some idea to the further investigation on the antioxidant mechanism of this bacterium.
Improved passive microwave sounding of the atmosphere (1996)

The effort this year focused primarily on 118-GHz transmittance experiments. The data analyzed here was collected with the Microwave Temperature Sounder (MTS) radiometer package during the CAMEX deployment of 1993 with the aim of validating current models of atmospheric microwave absorption in the O2 bands near 54 and 118 GHz. Particular attention has been paid to data collected during four flights when the MTS scanned zenith while profiles of downwelling radiances were collected through ascents and descents. These radiances, in conjunction with radiosonde temperature data, permit the retrieval of band-averaged absorption profiles for each channel. The Millimeter-wave Propagation Model (MPM92) provides theoretical expressions for the absorption of microwaves by oxygen and water vapor and accounts for the interference of pressure-broadened spectral lines'. This model is a good fit to laboratory measurements at temperatures ranging from 279-327 K, but it has been suggested that extrapolation to the conditions of the atmospheric tropopause may result in underestimation of absorption by as much as 15 percent. Preliminary results of the analysis of MTS data appear to be in general agreement with the predictions of the MPM model to within the accuracy of the measurements, which through the coldest parts of the atmosphere ranges from less than plus or minus 5 percent in the most opaque channels to greater than plus or minus 10 percent in the most transparent channels. At those altitudes where each channel is most sensitive to changes in absorption, there is some indication that the modeled absorption may be biased low relative to the observations. Accurate instrument calibration provided challenges, particularly when observed radiances were as much as 260 K below the temperatures of the cold calibration load.
Immunological studies on type 1 diabetes in identical twins. (1993)

Diabetes is a multifactorial disease, the pathogenesis of which involves participation of the host immune system in beta cell destruction. Studies on identical twins offer the opportunity to define genetic and non-genetic factors which may contribute to susceptibility to the disease. Our own work indicates that the number and nature, as well as the intensity and persistence of immune abnormalities of cellular and humoral immune responses can be powerful predictors of the disease and also identify twins who have a degree of protection from the disease.
Author Correction: Forecasting cell fate during antibiotic exposure using stochastic gene expression (2019)

[This corrects the article DOI: 10.1038/s42003-019-0509-0.].
ChemInform Abstract: Influence of the N‐Substituent on the Photophysical Properties of Oxacarbocyanines in Solution. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
THE IMPACT OF SEATBACK ANGLE ON ELECTROMYOGRAPHICAL ACTIVITY OF THE LOWER BACK AND QUADRICEPS MUSCLES DURING BILATERAL KNEE EXTENSION (2005)

This study investigated variations in electro-myographic (EMG) responses of the erector spinae (ES), vastus medialis (VM), rectus femoris (RF), and vastus lateralis (VL) to different seatback angles during leg extension. Twenty men and women (10 men, 10 women; age 27.49 6 6.16 years) performed 8 repetitions at 70% of 8 repetition maximum at seatback angles of 1.57, 1.75, and 1.92 radius (rad). Analyses using repeated-measures analysis of variance indicated the greatest root square mean of the EMG (rmsEMG) and integrated EMG (intEMG) for the ES were at 1.92 rad, and the greatest for the VM (concentric) and VL (eccentric) were at 1.57 rad. No differences were observed among seat angles for the RF except for a higher normalized intEMG at 1.92 than 1.75 rad (concentric). Throughout all sets for all conditions and muscles, rmsEMG and intEMG significantly increased and median power frequency significantly decreased. These data indicate that a seatback angle of 1.57 rad is best for a leg extension machine, because this angle maximizes quadriceps activity while minimizing stress on the lower back muscles.
Modes of cladded guides of arbitrary cross-sectional shape (1982)

An integral representation technique is described for calculating the modal properties of multilayered guides. Its equations are tested by comparison with results that can be derived by an alternative method for the special case of a thin ring guide. Numerical results are presented for general multilayered guides as a function of cladding thickness and of core and cladding shapes.
Partial purification and biological properties of thrombopoietin extracted from the urine of aplastic anemia patients. (1982)

Thrombopoietic (Tpo) and megakaryocyte-colony stimulating (Meg-CSF) activities were found in urinary extracts from patients with aplastic anemia. Preparative biochemical extractions were accomplished using Sephadex G-50 and DEAE-cellulose column chromatography. The biological activities of these extracts were assessed using not only an in vivo assay but were also examined in vitro employing the clonal development of megakaryocyte colonies. Both in vivo, as well as in vitro, biological activities were detected in the batch fraction which was stepwise eluted from DEAE-cellulose between 0.022 M NaCl in 0.016 M NaH2PO4 and 0.15 M NaCl in 0.05 M Na2HPO4 as a single fraction. When 0.4 mg of this fraction was injected daily into rats, a marked thrombopoiesis ensued producing an increase of 40% over initial platelet counts by 3 days after administration. This was followed by a decrease in platelets to a subnormal range by 21 days after the injection. Hemoglobin concentration gradually increased from 5% above initial value by day 7 to 20% above initial value by day 21. The effect of neuraminidase (NAse) on the properties of this extract was also examined. NAse-treated extracts, similar to the native extracts described above retained Tpo activity. Changes in megakaryocyte numbers in the spleen and bone marrow of rats were assayed with both the NAse-treated extract as well as with the native extract. A remarkable increase in megakaryocyte numbers, threefold above the normal count, was found in the spleens of rats given the native extract preparation; by contrast, however, no change was observed in splenic megakaryocyte numbers in rats given the NAse-treated extract. On the other hand, NAse-treated extract retained its ability to stimulate bone marrow megakaryocyte proliferation in the same rat. The urinary extract also revealed in vitro Meg-CSF activity with a specific activity of 31, 750 CFU-Meg colonies/mg of protein.
Preliminary Report on the Association of Apolipoprotein E Polymorphisms, with Postoperative Peak Serum Creatinine Concentrations in Cardiac Surgical Patients (2000)

Background Renal dysfunction after cardiac surgery occurs in up to 8% of patients and is associated with major increases in morbidity, mortality, and cost. Genetic polymorphisms have been implicated as a factor in the progression of chronic renal disease, but a genetic basis for the development of acute renal impairment has not been investigated. The authors therefore tested the hypothesis that apolipoprotein E alleles are associated with different postoperative changes in serum creatinine after cardiac surgery. Methods The authors performed a prospective observational study with use of data from 564 coronary bypass surgical patients who were enrolled in an ongoing investigation of apolipoprotein E genotypes and organ dysfunction at a university hospital between 1989-1999. Renal function was assessed among apolipoprotein E genotype groups by comparisons of preoperative (CrPre), peak in-hospital postoperative (CrMax) and perioperative change (DCr) in serum creatinine values. Results The epsilon4 allele grouping (E2 = 2/2,2/3,2/4; E3 = 3/3; E4 = 3/4,4/4) was associated with a smaller increase in postoperative serum creatinine (perioperative change: E4, +0.17; E3, +0.26; E4, +0.27 mg/dl) and a lower peak postoperative creatinine than the epsilon2 and epsilon3 in univariate and multivariate analysis (peak in-hospital postoperative serum creatinine multivariate P = 0.015 vs. epsilon3, P = 0.038 vs. epsilon2). There was no difference in baseline creatinine among allele groups. Conclusions Inheritance of the apolipoprotein epsilon4 allele is associated with reduced postoperative increase in serum creatinine after cardiac surgery, compared with the epsilon3 or epsilon2 allele. This is the first report of a possible genetic basis for acute renal impairment. These data may contribute to renal risk stratification for cardiac surgery and raise questions regarding apolipoprotein E and the pathophysiology of acute renal injury.
Density measure for line-drawing simplification (2004)

We present an approach for clutter control in NPR line drawing where measures of view and drawing complexity drive the simplification or omission of lines. We define two types of density information: the a-priori density and the causal density, and use them to control which parts of a drawing need simplification. The a-priori density is a measure of the visual complexity of the potential drawing and is computed on the complete arrangement of lines from the view. This measure affords a systematic approach for characterizing the structure of cluttered regions in terms of geometry, scale, and directionality. The causal density measures the spatial complexity of the current state of the drawing as strokes are added, allowing for clutter control through line omission or stylization. We show how these density measures permit a variety of pictorial simplification styles where complexity is reduced either uniformly, or in a spatially-varying manner through indication.
Crossover from reptation to Rouse dynamics in the cage model (2006)

The two-dimensional cage model for polymer motion is discussed with an emphasis on the effect of sideways motions, which cross the barriers imposed by the lattice. Using the density matrix method as a solver of the master equation, the renewal time and the diffusion coefficient are calculated as a function of the strength of the barrier crossings. A strong crossover influence of the barrier crossings is found and it is analyzed in terms of effective exponents for a given chain length. The crossover scaling functions and the crossover scaling exponents are calculated.
Substitution and fragmentation reactions of dibromododecacarbonyltriosmium with phosphines. Structure of dibromodecacarbonylbis(trimethyl phosphite)triosmium (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstitution and fragmentation reactions of dibromododecacarbonyltriosmium with phosphines. Structure of dibromodecacarbonylbis(trimethyl phosphite)triosmiumYu Sen Chen, Sue Lein Wang, Robert A. Jacobson, and Robert J. AngeliciCite this: Inorg. Chem. 1986, 25, 8, 1118–1122Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ic00228a012https://doi.org/10.1021/ic00228a012research-articleACS PublicationsRequest reuse permissionsArticle Views30Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Investigation of Near Ground Effects in Hover Flight for the Multi-Rotor Aircraft Volocopter-2X (2020)

High-fidelity CFD simulations of hovering flights of the multi-rotor Volocopter 2X (VC2X) aircraft with three different heights above the ground and an out of ground reference case are presented. The tool chain applied consists of the CFD solver FLOWer, which is loosely coupled to the flight mechanic tool VFAST. For all simulations an adequate representation of the flight mechanics is of crucial importance since the high number of trim degrees of freedom of the VC2X has a significant influence on the flight physics. A short introduction and validation of VFAST is carried out, which shows that VFAST already provides valuable stand-alone results for the considered flight envelope. The in ground and out of ground CFD simulations showed a highly complex flow field for the VC2X. With increasing ground proximity the number of vortex structures induced by the ground increases and the rotor wake is characterized by strong fluctuations. Basic rotorcraft in ground effect phenomena, like a high-pressure area below the rotor plane and aircraft power reduction are observed for low flight heights. The decreased power requirement is mainly traced back to a decrease of the airframe download. The system figure of merit for all three in ground cases merely changes.
Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors. (1995)

We constructed chimeras of the rat beta 2 and beta 4 neuronal nicotinic subunits to locate the regions that contribute to differences between the acetylcholine (ACh) dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 receptors. Expressed in Xenopus oocytes, the alpha 3 beta 2 receptor displays an EC50 for ACh approximately 20-fold less than the EC50 of the alpha 3 beta 4 receptor. The apparent Hill slope (n(app)) of alpha 3 beta 2 is near one whereas the alpha 3 beta 4 receptor displays an n(app) near two. Substitutions within the first 120 residues convert the EC50 for ACh from one wild-type value to the other. Exchanging just beta 2:104-120 for the corresponding region of beta 4 shifts the EC50 of ACh dose-response relationship in the expected direction but does not completely convert the EC50 of the dose-response relationship from one wild-type value to the other. However, substitutions in the beta 2:104-120 region do account for the relative sensitivity of the alpha 3 beta 2 receptor to cytisine, tetramethylammonium, and ACh. The expression of beta 4-like (strong) cooperativity requires an extensive region of beta 4 (beta 4:1-301). Relatively short beta 2 substitutions (beta 2:104-120) can reduce cooperativity to beta 2-like values. The results suggest that amino acids within the first 120 residues of beta 2 and the corresponding region of beta 4 contribute to an agonist binding site that bridges the alpha and beta subunits in neuronal nicotinic receptors.
Conventional Machining of an Aluminium Based SiC Reinforced Metal Matrix Composite (MMC) Alloy (1993)

Metal Matrix Composites (MMC’s) are a new class of materials intended for high performance applications. The paper outlines the results of a series of turning, face milling, drilling, reaming and tapping tests performed on an aluminium 2618 alloy reinforced with 15 vol% silicon carbide (SiC) particulate. High speed steel, cemented tungsten carbide and polycrystalline diamond (PCD) cutting tools were used. Based on a tool life criterion PCD products proved, in general, to be the most effective and the only tool material capable of providing a realistic operating performance. For instance, when using tungsten carbide drills only 48 holes could be made before lip flank wear reached 0.6 mm. PCD tipped drills cut 300 holes with only 0.08 mm of flank wear. In turning and to some extent in face milling operations, changes in cutting speed did not significantly effect flank wear rate. In drilling and reaming feed rate proved to be the key parameter.