gebhart/patrepeval huggingface dataset:
The effect of dietary arachidonic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans (1997)

Arachidonic acid (AA) is the precursor of thromboxane and prostacyclin, two of the most active compounds related to platelet function. The effect of dietary AA on platelet function in humans is not understood although a previous study suggested dietary AA might have adverse physiological consequences on platelet function. Here normal healthy male volunteers (n = 10) were fed diets containing 1.7 g/d of AA for 50 d. The control diet contained 210 mg/d of AA. Platelet aggregation in the platelet-rich plasma was determined using ADP, collagen, and AA. No statistical differences could be detected between the aggregation before and after consuming the high-AA diet. The prothrombin time, partial thromboplastin time, and the antithrombin III levels in the subjects were determined also. There were no statistically significant differences in these three parameters when the values were compared before and after they consumed the high-AA diet. The in vivo bleeding times also did not show a significant difference before and after the subjects consumed the high-AA diet. Platelets exhibited only small changes in their AA content during the AA feeding period. The results from this study on blood clotting parameters and in vitro platelet aggregation suggest that adding 1.5 g/d of dietary AA for 50 d to a typical Western diet containing about 200 mg of AA produces no observable physiological changes in blood coagulation and thrombotic tendencies in healthy, adult males compared to the unsupplemented diet. Thus, moderate intakes of foods high in AA have few effects on blood coagulation, platelet function, or platelet fatty acid composition.
The Effects Of Excess Silicon And Carbon In SiC Source Materials On Sic Single Crystal Growth In Physical Vapour Transport Method (2015)

This paper highlights the reaction processes occurring in Physical Vapour Transport (PVT) method for Silicon Carbide (SiC) single crystal in light of thermodynamics. A possible mechanism for SiC single crystal growth phenomena in PVT is reviewed briefly based upon the pressure-dependent Si-C equilibrium phase diagram. Consequently, description is applied to the case of surface graphitization of growing crystals, demonstrating that accurate thermodynamic understanding of the growth phenomena in PVT is quite important for the realization of larger diameter SiC single crystals with markedly reduced defect densities. Furthermore, the effect of source mixture compositions on the thermal decomposition process of the mixtures is also discussed. The process further involves examining the thermal decomposition processes of two exemplified cases of source powder mixtures with compositions of SiC(s)+C(s) and SiC(s)+Si(s) where SiC(s), C(s) and Si(s) represent solid SiC, solid graphite and solid silicon, respectively. It is suggested that, in the former SiC(s)+C(s) system, C(s) shows negligible evaporation unless the mutual mass exchange of carbon with the vapours is taken into account. Whereas, for the latter SiC(s)+Si(s) system, an ordinary SiC single crystal growth can occur if such source mixtures are adopted in PVT growths, but it strongly depends on the whole composition of the source mixture as well as the temperature gradient between the seed and the source.
The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. (2011)

The ability of FGF-2 to re-program a mineralizing gene expression profile to one of proliferation suggests that FGF-2 plays a critical role of osteoblast growth in early fracture repair while BMP-2 is instrumental in stimulating mineralization.
NONDESTRUCTIVE MEASUREMENT of TRANSIENT MOISTURE PROFILES and the MOISTURE DIFFUSION COEFFICIENT IN A POTATO DURING DRYING and ABSORPTION BY NMR IMAGING (1991)

ABSTRACT A nondestructive method to measure the internal moisture distribution and to determine the effective moisture diffusion coefficient for a potato during drying and absorption was developed using NMR imaging and numerical modeling techniques. the coefficients obtained were 1.04 to 7.28 × 10 −10 m 2 /s, for moisture contents between 40% and 55% (wb), during drying with a sample temperature of 40°C; and were 9.78 × 10 −12 to 2.33 × 10 −11 m 2 /s, for moisture contents between 56% and 60%, during absorption at 23°C.
Gram-negative bacterial endocarditis in narcotic addicts. (1973)

The number of cases of bacterial endocarditis in drug addicts seen at UCLA and Wadsworth Veterans Administration hospitals increased sharply in 1971 over the average of the four preceding years. Enteric Gram-negative bacilli were the infecting organism in three of the seven cases seen in 1971 but were not found in any cases of endocarditis in the 1967-70 period. Medical treatment of the patients was, in general, unsuccessful in spite of the intensive use of newer antimicrobials active against enteric Gram-negative bacilli. One patient died with fulminant Pseudomonas endocarditis and two others (Pseudomonas and Serratia endocarditis) eventually required operations on the heart before a cure was achieved.
ChemInform Abstract: Synthesis of Some Conformationally Restricted Analogs of Serotonin. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of a virtual environment for fault diagnosis in rotary machinery (2002)

Component fault analysis is a very widely researched area and requires a great deal of knowledge and expertise to establish a consistent and accurate tool for analysis. This paper will discuss a virtual diagnostic tool for fault detection of rotary machinery. The diagnostic tool has been developed using FMCELL software, which provides a 3D graphical visualization environment to modeling rotary machinery with virtual data acquisition capabilities. The developed diagnostic tool provides a virtual testbed with suitable graphical user interfaces for rapid diagnostic fault analysis of machinery. In this paper, we will discuss details of this newly developed virtual diagnostic model using FMCELL software and present our approach for diagnostics of a mechanical bearing test bed (TSU-BTB). Furthermore, we will provide some examples of how the virtual diagnostic environment can be used for performing machinery fault diagnostics. Using a frequency pattern matching superimposing technique, the model is proven to be able to detect primary faults in machines with fair accuracy and reliability.
THE ESTIMATION OF MISSING AND MIXED-UP OBSERVATIONS IN SEVERAL EXPERIMENTAL DESIGNS (1959)

Journal Article THE ESTIMATION OF MISSING AND MIXED-UP OBSERVATIONS IN SEVERAL EXPERIMENTAL DESIGNS Get access J. D. BIGGERS J. D. BIGGERS Department of Physiology, Royal Veterinary CollegeLondon Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 46, Issue 1-2, June 1959, Pages 91–105, https://doi.org/10.1093/biomet/46.1-2.91 Published: 01 June 1959
CHANGES OF 3H-DOPAMINE AND 3H-GABA RELEASE IN THE RAT BASAL GANGLIA INDUCED BY PHARMACOLOGICAL MODIF=ICATIONS OF DOPAMINERGIC TRNSMISSION (1984)

Besson, M. J.; Girault, J. A.; Truong, N. A.; Glowinski, J.; Savaki, H. E. Author Information
Active filter operation providing unity power factor supply system for drives and battery charging (2002)

The paper presents the concept of a parallel active filter which can compensate the nonactive power in the supply line and can also operate as a controlled DC source to supply an electric drive. Such a system provides sinusoidal shape of input current and operates with unity power factor. Simulation studies and laboratory tests have been carried out to study the performance of the filter in two cases. In the first case the filter compensates the nonactive power in the line without any DC load connected to the filter and in the second case a DC load is also linked to it. The control diagram of the system is proposed and tested. The filter uses an AC/DC converter with a diode bridge rectifier.
Meat and Bone Meal and Mineral Feed Additives May Increase the Risk of Oral Prion Disease Transmission (2011)

Ingestion of prion-contaminated materials is postulated to be a primary route of prion disease transmission. Binding of prions to soil (micro)particles dramatically enhances peroral disease transmission relative to unbound prions, and it was hypothesized that micrometer-sized particles present in other consumed materials may affect prion disease transmission via the oral route of exposure. Small, insoluble particles are present in many substances, including soil, human foods, pharmaceuticals, and animal feeds. It is known that meat and bone meal (MBM), a feed additive believed responsible for the spread of bovine spongiform encephalopathy (BSE), contains particles smaller than 20 μm and that the pathogenic prion protein binds to MBM. The potentiation of disease transmission via the oral route by exposure to MBM or three micrometer-sized mineral feed additives was determined. Data showed that when the disease agent was bound to any of the tested materials, the penetrance of disease was increased compared to unbound prions. Our data suggest that in feed or other prion-contaminated substances consumed by animals or, potentially, humans, the addition of MBM or the presence of microparticles could heighten risks of prion disease acquisition.
CARs expressing CD28 and 4-1BB demonstrate increased intracellular signaling activity and proliferative capacity while maintaining a memory phenotype upon repeated antigen stimulation (2014)

Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. T cells expressing these chimeric antigen receptors (CARs) could recognize and specifically kill tumor cells. However the T cells, lacked in persistence and tumor rejection did not occur. Thus, the CAR constructs have been improved by providing the T cell with costimulatory signals promoting activation. The focus of this thesis has been to evaluate second and third generation αCD19-CAR T cells for the treatment of B cell leukemia and lymphoma.B cell tumors commonly upregulate anti-apoptotic proteins such as Bcl-2, which generates therapy resistance. In the first paper a second generation (2G) αCD19-CD28-CAR T cell was combined with the Bcl-2 family inhibitor ABT-737. ABT-737 sensitized tumor cells to CAR T cell therapy and may be an interesting clinical combination treatment. In paper II, the phenotype and function of a third generation (3G) αCD19-CD28-4-1BB-CAR T cell were evaluated. B cell-stimulated CAR T cells showed increased proliferation and an antigen-driven accumulation of CAR+ T cells. 3G CAR T cells had equal cytotoxic capacity, similar lineage, memory and exhaustion profile phenotype compared to 2G CARs. However, 3G CAR T cells proliferated better and had increased activation of intracellular signaling pathways compared to 2G CAR T cells. In paper III, αCD19-CD28-4-1BB-CAR T cells were used to stimulate immature dendritic cells leading to an upregulation of maturation markers on co-cultured dendritic cells. Hence, CAR T cells may not only directly kill the tumor cells, but may induce bystander immunity that indirectly aids tumor control. This thesis also include supplementary information about the development and implementation of protocols for GMP production of CAR T cell batches for a phase I/IIa clinical trial currently ongoing for patients with refractory B cell leukemia and lymphoma. So far, two patients have safely been treated on the lowest dose.
Identification of case clusters and counties with high infective connectivity in the 2001 epidemic of foot-and-mouth disease in Uruguay (2006)

Analysis of spatial autocorrelation and infective link indices may identify network conditions that facilitate (or prevent) disease spread.
The Crystal Structure and Magnetic Properties of a New Ferrimagnetic Semiconductor: Ca<sub>21</sub>Mn<sub>4</sub>Sb<sub>18</sub>. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Resolver Angle Estimator Based on Its Excitation Signal (2008)

A resolver generates a pair of signals proportional to the sine and cosine of the angular position of its shaft. A new low-cost method for converting the amplitudes of these sine/cosine transducer signals into a measure of the input angle without using lookup tables is proposed. The new method takes advantage of the components used to operate the resolver, the excitation (carrier) signal in particular. This is a feedforward method based on comparing the amplitudes of the resolver signals to those of the excitation signal together with another shifted by pi/2. A simple method is then used to estimate the shaft angle through this comparison technique. The poor precision of comparison of the signals around their highly nonlinear peak regions is avoided by using a simple technique that relies only on the alternating pseudolinear segments of the signals. This results in a better overall accuracy of the converter. Beside simplicity of implementation, the proposed scheme offers the advantage of robustness to amplitude fluctuation of the transducer excitation signal.
Combustion characteristics of oxygenated fuels Ethanol-and Butanol-gasoline fuel blends, and their impact on performance, emissions and Soot Index (2019)

<div class="section abstract"><div class="htmlview paragraph">Oxygenated fuels are studied in spark combustion engines because of their potentially positive impact on greenhouse emissions, and as part of alternative renewable fuels. Furthermore, engine test results position them as a promising lever to reduce engine-out emissions, and most notably, particles. This study focuses on oxygenated fuel Butanol, which is a potential output of recent developments on Algae and Cyanobacteria harvest process. Its blending into gasoline and application into spark ignition engines is investigated. Blending levels of n-Butanol and iso-Butanol have been proposed based on standard gasoline’s octane number, RON, at two ethanol concentration levels, 10 and 25%. Fuel blend impact on combustion, and on regulated and non-regulated emissions is analysed. Fuel knock resistance properties, RON and MON, determine the knocking tendencies for ethanol and butanol at 2000 rpm. However, test results highlight different knocking sensibility behaviour at higher engine speed. Emission results also illustrate a strong advantage of Butanol on particle mass emissions. Soot indices, that are conventionally used to quantify the impact of a fuel over particle emissions, are studied and confronted to results obtained on ethanol blends. The deviation in Particle Matter Indices obtained for butanol blends is analysed, on the basis of specific operating points. It highlights different particle emissions responses to the increase of oxygenates ethanol and butanol, not uniquely correlated to oxygen and aromatic concentration.</div></div>
Multi-wavelength observations of PKS 2155-304 with HESS (2005)

The High Energy Stereoscopic System (HESS) has observed the high-frequency peaked BL Lac object PKS 2155PKS -304 in 2003 between October 19 and November 26 in Very High Energy (VHE) -rays (E 160 GeV for these observations). Observations were carried out simultaneously with the Proportional Counter Array (PCA) on board the Rossi X-ray Timing Explorer satellite (RXTE), the Robotic Optical Transient Search Experiment (ROTSE) and the Nanay decimetric radiotelescope (NRT). Intra-night variability is seen in the VHE band, the source being detected with a high significance on each night it was observed. Variability is also found in the X-ray and optical bands on kilosecond timescales, along with flux-dependent spectral changes in the X-rays. A transient X-ray event with a 1500 s timescale is detected, making this the fastest X-ray flare seen in this object. No correlation can be established between the X-ray and the -ray fluxes, or any of the other wavebands, over the small range of observed variability. The average HESS spectrum shows a very soft power law shape with a photon index of 3.37 0.07 stat 0.10 sys . The energy outputs in the 2-10 keV and in the VHE -ray range are found to be similar, with the X-rays and the optical fluxes at a level comparable to some of the lowest historical measurements, indicating that PKS 2155-304 was in a low or quiescent state during the observations. Both a leptonic and a hadronic model are used to derive source parameters from these observations. These parameters are found to be sensitive to the model of Extragalactic Background Light (EBL) that attenuates the VHE signal at this source's redshift (z = 0.117).
CELL CYCLE-DEPENDENT COUPLING OF VASOPRESSIN V1-RECEPTOR TO Gq/11, AND Gi3 (1999)

Conference Abstract| February 01 1999 CELL CYCLE-DEPENDENT COUPLING OF VASOPRESSIN V1-RECEPTOR TO Gq/11, AND Gi3 Frank Kalkbrenner; Frank Kalkbrenner 1Institut für Pharmakologie, Freie Universität Berlin, Thielallee 69/71, 14195 Berlin2Preclinical Drug Research, Schering AG, 13342 Berlin, Germany Search for other works by this author on: This Site PubMed Google Scholar Alexander Abel; Alexander Abel 1Institut für Pharmakologie, Freie Universität Berlin, Thielallee 69/71, 14195 Berlin2Preclinical Drug Research, Schering AG, 13342 Berlin, Germany Search for other works by this author on: This Site PubMed Google Scholar Norbert Wittau; Norbert Wittau 1Institut für Pharmakologie, Freie Universität Berlin, Thielallee 69/71, 14195 Berlin2Preclinical Drug Research, Schering AG, 13342 Berlin, Germany Search for other works by this author on: This Site PubMed Google Scholar Günter Schultz Günter Schultz 1Institut für Pharmakologie, Freie Universität Berlin, Thielallee 69/71, 14195 Berlin2Preclinical Drug Research, Schering AG, 13342 Berlin, Germany Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1999) 27 (1): A25. https://doi.org/10.1042/bst027a025c Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Frank Kalkbrenner, Alexander Abel, Norbert Wittau, Günter Schultz; CELL CYCLE-DEPENDENT COUPLING OF VASOPRESSIN V1-RECEPTOR TO Gq/11, AND Gi3. Biochem Soc Trans 1 February 1999; 27 (1): A25. doi: https://doi.org/10.1042/bst027a025c Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1999 Biochemical Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.
Stress-induced and electromigration voiding in aluminum interconnects passivated with silicon nitride (2002)

Void nucleation in aluminum interconnects passivated with silicon nitride was studied using a high voltage scanning electron microscope. Extensive stress-induced voiding was observed in these interconnects independent of the passivation thickness. Some of the stress-induced and electromigration-induced voids formed away from the interconnect sidewall in contrast to results from other studies of void nucleation in passivated aluminum lines. Nuclear reaction analysis measured large amounts of hydrogen in the aluminum films passivated with silicon nitride. Transmission electron microscopy showed a high density of nanometer-sized bubbles in the aluminum. These bubbles, which are thought to have formed from hydrogen that evolved from the silicon nitride layer during processing, served as nucleation sites for stress- and electromigration-induced voids.
Surface Analysis of Polymeric Joints (1993)

Abstract The stability of polymer-to-polymer joints was assessed using a thermodynamic method based on surface tension components, similar to that developed by Kinloch et al.,1 showing that joint stability is improved in air by plasma treatments, while it is depressed in water. Shear strength tests showed qualitative agreements with these suggestions. Surface analysis by contact angle measurements, SSIMS and XPS allowed the clarification of contributions which originated from phenomena unaccounted for by thermodynamic analysis. Plasma treatment was shown to form a weak boundary layer on polypropylene surfaces, possibly due to depolymerization. In the case of polycarbonate a water sensitive, possibly water soluble, layer is formed, therefore inducing a remarkable decrease in shear strength upon immersion in water.
Rapid assessment of isoenzymes by high-performance liquid chromatography. (1978)

Abstract We describe the rapid profiling of isoenzymes by use of microparticulate anion-exchange chromatography supports and a continuous, post-separation enzyme detector in a high-performance liquid chromatograph. Chromatographic analysis and enzyme detection are fully automated and provide excellent reproducibility. Factors affecting the isoenzyme profile and detector response characteristics are assessed. Lactate dehydrogenase and creatine kinase isoenzymes in tissue extracts, control materials used as electrophoretic standards, and serum were profiled by this method to establish the resolution and reliability of the method. We show the clinical use of this method in detecting changes in these isoenzymes in serum associated with acute myocardial infarction.
[Microbial settlement of paint- and building-materials in the sphere of drinking-water. 2. Information: experimental examination of bitumen paint under working conditions (author's transl)]. (1978)

A bituminous coating material for drinking water reservoirs was applied on testing plates for a microbial examination. In function of the chlorine content of the water a microbial slime layer could be found on the testing plates. The amount of slime became less in course of the time or was not produced at all, when the plates were desiccated before the experiment for some months. A slime layer could never be observed on plates of asbestos cement and polyacryl as inert materials for comparison. Different microbial populations were observed.
Chemical-Garden Formation, Morphology, and Composition. II. Chemical Gardens in Microgravity (2011)

We studied the growth of metal-ion silicate chemical gardens under Earth gravity (1 g) and microgravity (μg) conditions. Identical sets of reaction chambers from an automated system (the Silicate Garden Habitat or SGHab) were used in both cases. The μg experiment was performed on board the International Space Station (ISS) within a temperature-controlled setup that provided still and video images of the experiment downlinked to the ground. Calcium chloride, manganese chloride, cobalt chloride, and nickel sulfate were used as seed salts in sodium silicate solutions of several concentrations. The formation and growth of osmotic envelopes and microtubes was much slower under μg conditions. In 1 g, buoyancy forces caused tubes to grow upward, whereas a random orientation for tube growth was found under μg conditions.