gebhart/patrepeval huggingface dataset:
The Effect of Disintegrin–Metalloproteinase ADAM9 in Gastric Cancer Progression (2014)

Advanced gastric cancer is one of the most aggressive gastrointestinal malignancies, and ADAM (A disintegrin and metalloproteinase)-9 is a cell-surface membrane glycoprotein with oncogenic properties that is overexpressed in several cancers. Herein, we investigated the biologic mechanism of ADAM9 in the progression, proliferation, and invasion of gastric cancer. First, we detected ADAM's expression, processing, and protease activity in gastric cancer cells. Protease activity was moderately correlated with ADAM9 protein expression, but was better related to a processed smaller molecular weight (84 kDa) form of ADAM9. Knockdown of ADAM9 or specifically targeted monoclonal antibody (RAV-18) suppressed cancer cell proliferation and invasion in high ADAM9-expressing cells, not in low ADAM9-expressing cells. RAV-18 showed in vivo antitumor activity in a gastric cancer xenograft model. Hypoxia (1% oxygen) induced ADAM9 expression and functional activity in low ADAM9-expressing gastric cancer cells that was inhibited by siRNA knockdown or RAV-18 antibody to levels in normoxic cells. Overall, our studies show that ADAM9 plays an important role in gastric cancer proliferation and invasion, and that while expressed in some gastric cancer cells at high levels that are responsive to functional inhibition and antitumor activity of a catalytic site-directed antibody, other gastric cancer cells have low levels of expression and only when exposed to hypoxia do ADAM9 levels increase and the cells become responsive to ADAM9 antibody inhibition. Therefore, our findings suggest that ADAM9 could be an effective therapeutic target for advanced gastric cancer.
A CONTINUOUS-TIME REEXAMINATION OF DOLLAR-COST AVERAGING (2003)

The widespread practice of dollar-cost averaging (DCA) amongst the investing public, has puzzled most financial economists, ever since Constantinides [2] demonstrated the dynamic inefficiency of this strategy under very general conditions. This enduring phenomena has forced researchers, such as Statman [12], to suggest behavioral explanations for DCA's popularity, predicated on the prospect theory of Kahneman and Tversky [4]. In this paper we reexamine the payoff structure of DCA via continuous-time financial mathematics and then ask the question: Is it possible to reconcile the theory and practice of dollar-cost averaging? To answer this question, we take a slightly different approach to the issue by using the tools of stochastic calculus and Brownian bridges. We demonstrate that engaging in a dollar-cost averaging strategy is akin to purchasing a zero strike arithmetic Asian option on the underlying security. In other words, people who engage in dollar-cost averaging are implicitly purchasing a path-dependent contingent claim. We then prove that the expected return from this exotic option — i.e. the DCA strategy — conditional on knowing the final value of the security will uniformly exceed the return from the underlying security for all sufficiently large volatilities. This leads us to argue that investors may be dollar-cost averaging because they have "target prices" for the underlying asset price. The strategy of dollar-cost averaging would then exceed the returns from lump-sum investing, based on their subjective conditional expectation. In fact, the more volatile the underlying security, the greater is the benefit to dollar-cost averaging — conditional on knowing the final value — which is consistent with common practice.
NOTES ON A HITHERTO UNKNOWN SPECIMEN OF NEOLESBIA-NEHRKORNI BERLEPSCH 1887 TROCHILIDAE WITH A DISCUSSION OF THE HYBRID ORIGIN OF THIS SPECIES (1991)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Explosive decomposition of hydrazine due to rapid gas compression (1985)

Results from tests which attempt to determine conditions which cause explosive decomposition of hydrazine from rapid gas compression are described. Hydrazine was initiated by pressure in combination with shock waves from the pressurant gas. A new test method was developed at the White Sands Test Facility which subjects a gas bubble in contact with liquid hydrazine to pure adiabatic compression. Results from this new test method are compared to those from the U-tube method.
<title>Holographic 3-D printer</title> (1990)

This paper proposes a holographic printer, which produces 3-D hard copies of
computer processed objects. For the purpose of automatic making of 3-D hard copies
of distortion free, a new method to synthesize holographic stereogram is proposed.
It is is flat format and lippmann type holographic stereogram which can be printed
by one optical step. The proposed hologram has not only horizontal parallax but
vertical parallax, so that the reconstructed image is completely free from distortions.
Though a basic experiment, a holographic stereogram of 8.Ox6.4cm2 was
synthesized and a 3-D image is correctly reconstructed. In this paper the principle
and the method of the new technique are described, and the system constitution' and
the problems with the holographic 3-D printer are also discussed.
Polysilicon interconnections (FEOL): Fabrication and characterization (2009)

Three dimensional silicon integration technologies are gaining considerable attention as the traditional CMOS scaling becoming more challenging and less beneficial. The advanced packaging solutions based on thin silicon carrier are being developed to interconnect integrated circuits and other devices at high densities. A key enabling technology element of the silicon carrier is through silicon via (TSV), which can provide vertical interconnects in stacked ICs. In this paper, we present vias-first process to realize vertical interconnects that is fully FEOL compatible. The vias are filled by doped polysilicon and wafers with such pre-fabricated vias can be used as the starting wafers for any CMOS device processing. The process details and their characterization are elaborated along with the physical and electrical analysis of such vias.
Die rauchförmigen Blaseverluste beim basischen Windfrischen (1951)

Eisenverluste im braunen Konverterrauch. Entwicklung eines optischen Meßverfahrens zur Erfassung der Anzahl der Rauchteilchen im Abgas. Bestimmung des Absorptionsvermögens. Die rauchförmigen Blaseverluste betragen 0,02 % des Schmelzgewichts. Bestimmung des Dampfdruckes von Eisen.
Hyaluronan Synthesis Induces Microvillus-like Cell Surface Protrusions (2006)

Hyaluronan synthases (HASs) are plasma membrane enzymes that simultaneously elongate, bind, and extrude the growing hyaluronan chain directly into extracellular space. In cells transfected with green fluorescent protein (GFP)-tagged Has3, the dorsal surface was decorated by up to 150 slender, 3-20-microm-long microvillus-type plasma membrane protrusions, which also contained filamentous actin, the hyaluronan receptor CD44, and lipid raft microdomains. Enzymatic activity of HAS was required for the growth of the microvilli, which were not present in cells transfected with other GFP proteins or inactive GFP-Has3 mutants or in cells incubated with exogenous soluble hyaluronan. The microvilli induced by HAS3 were gradually withered by introduction of an inhibitor of hyaluronan synthesis and rapidly retracted by hyaluronidase digestion, whereas they were not affected by competition with hyaluronan oligosaccharides and disruption of the CD44 gene, suggesting independence of hyaluronan receptors. The data bring out the novel concept that the glycocalyx created by dense arrays of hyaluronan chains, tethered to HAS during biosynthesis, can induce and maintain prominent microvilli.
Azole Endothelin Antagonists. 1. A Receptor Model Explains an Unusual Structure−Activity Profile (1996)

The pseudotetrapeptide FR-139317 is a potent and highly selective antagonist of the endothelin-A (ET(A)) receptor; however, its peptidic nature leads to poor oral absorption characteristics which make it an unlikely drug candidate. In an attempt to improve these properties, we have replaced a portion of the amide bond framework of FR-139317 with a heterocyclic surrogate. The resultant analogs are also ET(A)-selective antagonists, but show a structure-activity profile substantially different from that of the peptidic series, particularly with regard to the requirements for the side chain group that has been incorporated into the heterocycle. The nature of the heterocycle itself also has profound effects on the activity of the compounds. Both of these surprising results can be rationalized through examination of a 3D model of ET ligand--receptor binding that has previously been developed in our laboratories.
Social media and customer behavior analytics for personalized customer engagements (2014)

Companies in various industries, including travel, hospitality, and retail, increasingly focus on improving customer relationships and customer loyalty. In this paper, we propose a new systems architecture that combines the textual content in social media messages with product information, such as the descriptions summarized in catalogs, in order to provide marketing campaign recommendations. Companies commonly build user profiles based on purchase histories and other customer-specific information; however, when dealing with social media, we often cannot match the social media users with the customers. In this regard, we address the problem of targeting individual social media messages for which no personalized profile information can be retrieved. Our solution combines two disparate computational toolboxes for text analytics—natural language processing and machine learning—in order to select social media users for whom to target with topic-specific advertisements. Natural language processing is used to analyze the context of social media messages, and machine learning is used to analyze product information, with the goal being to match social media messages to products and ranking potential advertisements. To demonstrate the framework, we detail a real-world application in the travel and tourism industry using Twitter® as the social media platform.
Oligocyclic Ladder Polysiloxanes:  Alternative Synthesis by Oxidation (2005)

A series of ladder polysiloxanes was prepared by oxidation of the corresponding ladder polysilanes with mCPBA (m-chloroperbenzoic acid), and their structures were determined. Complete oxidation of all Si−Si bonds was accomplished with a large excess of mCPBA using long reaction times.
Imaging rounds #97. Salter II fracture of the proximal tibia. (1989)

Proximal tibial physeal injury is extremely rare. It occurs most often in adolescents and is the result of a significant abduction force applied to the lower leg with the foot firmly fixed. Management of this injury follows the same principles as other Salter-Harris epiphyseal plate fractures. Prognosis is generally good, although there is a somewhat higher than anticipated incidence of angulatory and longitudinal deformities of Type I and Type II fractures, much as has been observed in distal femoral physeal fractures. This is probably due to direct injury to the germinal layer of the growth plate with subsequent partial physeal closure.
Correction to “Computationally Guided Discovery of Catalytic Cobalt-Decorated Metal–Organic Framework for Ethylene Dimerization” (2017)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Computationally Guided Discovery of Catalytic Cobalt-Decorated Metal–Organic Framework for Ethylene Dimerization"Varinia Bernales, Aaron B. League, Zhanyong Li, Neil M. Schweitzer, Aaron W. Peters, Rebecca K. Carlson, Joseph T. Hupp, Christopher J. Cramer, Omar K. Farha, and Laura Gagliardi*Cite this: J. Phys. Chem. C 2017, 121, 21, 11975Publication Date (Web):May 10, 2017Publication History Published online10 May 2017Published inissue 1 June 2017https://pubs.acs.org/doi/10.1021/acs.jpcc.7b03864https://doi.org/10.1021/acs.jpcc.7b03864correctionACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views816Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (683 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Methods for Determining Lead in Air and in Biological Materials (1945)

Methods for Determining Lead in Air and in Biological Materials Affiliation Samuel Moskowitz CopyRight https://doi.org/10.2105/AJPH.35.11.1230-a Published Online: August 29, 2011
The Pope Air Force Base Aircraft Crash and Burn Disaster (2005)

This report describes the initial hospital and burn center management of a mass casualty incident resulting from an aircraft crash and fire. One hundred thirty soldiers were injured, including 10 immediate fatalities. Womack Army Medical Center at Fort Bragg, North Carolina, managed the casualties and began receiving patients 15 minutes after the crash. As a result of repetitive training that included at least two mass casualty drills each year, the triage area and emergency department were cleared of all patients within 2 hours. Fifty patients were transferred to burn centers, including 43 patients to the US Army Institute of Surgical Research. This constitutes the largest single mass casualty incident experienced in the 57-year history of the Institute. All patients of the US Army Institute of Surgical Research survived to hospital discharge, and 34 returned to duty 3 months after the crash. The scenario of an on-ground aircraft explosion and fire approximates what might be seen as a result of an aircraft hijacking, bombing, or intentional crash. Lessons learned from this incident have utility in the planning of future response to such disasters.
Sensitivity of the performance of optimal control systems to plant parameter variations (1965)

Publisher Summary This chapter discusses the sensitivity of the performance of optimal control systems to plant parameter variations. The problem or determining the change in value or a performance index with parameter variations, and outlined a method or computing the performance index sensitivity functions is considered. The system to be controlled is described by the vector differential equation x = f (t, x, u, a), x(t0) = x0, where x is a n-dimensional column vector representing the state of the plant and u is an r-dimensional column vector representing the control input. The vector a = (a1, a2, …, am) represents a set of plant parameters. The chapter also discusses closed- and open-loop systems.
Expansion of newborn screening programs using automated tandem mass spectrometry (1999)

Developments and improvements in the application of tandem mass spectrometry for newborn screening of inherited metabolic diseases using dried blood specimens have been ongoing since the initial work with fast atom bombardment ionization tandem mass spectrometry for phenylketonuria and other amino acid disorders was started in 1990. Previous work with acylcarnitine analysis of clinical samples was easily adapted and combined with the amino acid analysis such that a single analysis for both acylcarnitine and amino acid screening was accomplished. With the introduction of electrospray ionization techniques, great progress towards full automation was made resulting in a state-of-the-art, cost-effective method for diagnosis of multiple metabolic diseases in a single analytical run including phenylketonuria, maple syrup urine disease, homocystinuria, medium chain acyl-CoA dehydrogenase deficiency, as well as other disorders in amino, organic, and fatty acid metabolism. Currently, more than 1,000 samples per day are routinely analyzed in our program. Over 139 clinically significant and treatable disorders have been detected out of over 560,000 newborns screened. MRDD Research Reviews 1999;5:150–154. © 1999 Wiley-Liss, Inc.
Fluctuation-Based Super-Resolution Traction Force Microscopy (2019)

Abstract Cellular mechanics play a crucial role in tissue morphogenesis and homeostasis and are often misregulated in disease. Traction force microscopy (TFM) is one of the key methods that has enabled researchers to study fundamental aspects of mechanobiology; however, the power of TFM is limited by poor resolution and low throughput. Here, we propose a simplified protocol and imaging strategy, relying on super-resolution microscopy enabled by fluorophore fluctuation analysis, to enhance the output of TFM, by increasing both bead density as well as the accuracy of bead tracking in TFM gels. Our analysis pipeline can be used on either camera-based confocal or widefield microscopes and is fully compatible with available TFM analysis software. In addition, we demonstrate that our workflow can be used to gain biologically relevant information and is suitable for long-term live measurement of traction forces even in light-sensitive cells. Finally, we propose that our strategy could be used to considerably simplify the implementation of TFM screens. Our streamlined protocol can be performed with minimal hardware and software investment, and has the potential to standardize high-resolution TFM.
The Structural Brain Correlates of Cognitive Deficits in Adults with Klinefelter’s Syndrome (2006)

This study hypothesizes that supernumerary X-chromosome and/or congenital hypogonadism provoke structural alterations in the subcortical pathways involved in language processing, thus providing a neurobiological substrate for cognitive deficits in KS.
Comparative Study of Multiencoding Schemes for OCDM Using a Single Multiport Optical Encoder/Decoder (2007)

We analyse the performance of multicode shift keying modulation in an optical code-division multiplexing network scenario and demonstrate the effectiveness of using a single multiport optical encoder/decoder as a source coding element. We assign a set of codes to each user, and numerically evaluate the system performances, in terms of bit-error rate and spectral efficiency
Magnetic force microscopy observations of Co nanoparticles grown on annealing Co10Cu90 melt spun ribbons (2006)

The growth of magnetic clusters by annealing melt spun Co10Cu90 ribbons has been investigated with magnetic force microscopy (MFM) and conventional magnetometry. No clear magnetic structures were observed by MFM in the as-quenched samples. After annealing the samples at 500°C, magnetic Co particles with a mean size of 110±30nm were observed. Further annealing to 750°C increased the Co particle size, which reaches a maximum value of 600nm, and multidomain magnetic structures were observed. The magnetization reversal of these Co nanoparticles was observed by MFM with in situ applied magnetic fields. The MFM observations of an increase in both the density and size of stable Co nanoparticles with increased annealing temperatures are in qualitative agreement with the magnetometry data which indicate a doubling of the magnetization of the Co10Cu90 ribbons after annealing at 750°C.
OFDM clipping distortion compensation using an iterative method (2006)

In this paper, an iterative method for re- construction of band limited signals from nonuniform samples is used for clipping noise cancellation and then it is examined in Rician fading channels. Simulation results show that the proposed method can outperform OFDM systems in BER (Bit Error Rate) performance point of view.
Loop-Back Optical Heterodyne Technique for 1.0-Gb/s Data Transmission Over 60-GHz Radio-On-Fiber Uplink (2007)

An optical-heterodyne-detection method for a 60-GHz radio-on-fiber uplink is proposed and verified in this paper. The main point of this proposal is that all the functions needed for the optical heterodyne detection, i.e., the local/carrier light sources, the automatic frequency control of these light sources, and a polarization-diversity-detection circuit, are consolidated in one transmitting-side module to realize a simple system configuration. This proposal realizes an adequate optical uplink budget with low-cost optical receivers that consist of just one IF-band photodetector and one envelope detector. A 1.0-Gb/s transmission experiment over 10 km of single-mode fiber, which represents access-network transmission, is demonstrated using a 61.0-GHz amplitude-shift-keying signal as a 60 GHz-band uplink signal. A BER of less than 10-9 was obtained at an uplink SSB signal power of -40 dBm regardless of the polarization state of the optical uplink signal, and no significant dispersion-induced degradation was noted.
Integration of heterogeneous scientific data using workflows - a case study in bioinformatics (2004)

The goal of the described project is to design, implement, evaluate and deploy a suite of tools and network-based services that reliably improve productivity of research scientists by providing proactive information technology based support for their problem solving workflows. In the first phase of the project we have focused on workflow support toolset that aids bioinformatics research workflows. The architecture is based on a proactive scientific data analysis model, the latest service delivery methodologies, and the emerging semantic and context-based analysis paradigms. The key is to speed-up, robustify, and render appliance-like information technology related components of the scientific workflows.
Numerical Model for Reinforced Soil Segmental Walls under Surcharge Loading (2006)

The construction and surcharge loading response of four full-scale reinforced-soil segmental retaining walls is simulated using the program FLAC. The numerical model implementation is described and constitutive models for the component materials (i.e., modular block facing units, backfill, and four different reinforcement materials) are presented. The influence of backfill compaction and reinforcement type on end-of-construction and surcharge loading response is investigated. Predicted response features of each test wall are compared against measured boundary loads, wall displacements, and reinforcement strain values. Physical test measurements are unique in the literature because they include a careful estimate of the reliability of measured data. Predictions capture important qualitative features of each of the four walls and in many instances the quantitative predictions are within measurement accuracy. Where predictions are poor, explanations are provided. The comprehensive and high quality physical data reported in this paper and the lessons learned by the writers are of value to researchers engaged in the development of numerical models to extend the limited available database of physical data for reinforced soil wall response.