gebhart/patrepeval huggingface dataset:
An immunohistochemical study of thrombomodulin in oral squamous cell carcinoma and its association with invasive and metastatic potential (1997)

Thrombomodulin (TM) is a glycoprotein that was originally identified on vascular endothelium and characterized as a natural endothelial anticoagulant. We reported previously that TM was also expressed at cell-cell boundaries of squamous epithelium, except in the basal layer cells and upper granular layer cells. The expression pattern of TM in the squamous cells implies that this molecule might be associated with keratinocyte differentiation, as well as being a potent anticoagulant. In the present study we examined TM expression immunohistochemically in biopsy specimens from 65 patients with primary oral squamous cell carcinoma (OSCC), and compared the results with the biological behavior of the carcinomas. The patients with intense TM expression in the carcinoma showed a significantly lower frequency of lymph node metastasis and significantly more favorable survival than those with negative TM expression. The TM expression was a better marker than the other prognostic factors, such as differentiation degree, tumor size and invasion mode. When TM expression was compared between the primary and metastatic lesions in the 36 patients who had lymph node metastasis, 14 (39%) showed decreased TM expression, 19 (53%) showed no change, and 3 (8%) showed an increase in the metastatic lesions. Wilcoxon's signed-rank test indicated that tumor cells positive for TM expression were significantly rarer in the metastatic lesions than in the primary tumors (P < 0.05). These results indicate that reduced expression of TM is associated with metastasis of carcinoma cells. The reduction of TM expression seems to play an important role in the metastatic process of OSCC, and to be related with a poor outcome for the patients.
High-Resolution Density Gradient Sedimentation Analysis (1960)

The principle of stability for a sample layered in a density-gradient liquid column is discussed, and a method for separating ribonucleoprotein particles by means of sedimentation in the ultracentrifuge is described.
The stability of axisymmetric menisci (1973)

Abstract The conditions that govern the equilibrium and stability of a meniscus have been obtained from the first and second derivatives of the energy of the meniscus when it undergoes axisymmetric deformation. The energy of forming a meniscus is defined in thermodynamic terms and methods are given for calculating the free energy of a mensicus in the perturbed and unperturbed state. The stable, critically stable and unstable equilibrium states of a meniscus are all defined in terms of an energy profile, that is, the variation of energy with degree of perturbation. The variational problem of defining parameters for a critically stable meniscus is solved graphically by using a three-dimensional cluster of energy profiles, and it is shown that certain properties of the meniscus, notably volume or pressure, reach limiting values at critical conditions. Four types of stability are considered for each of three forms of axisymmetric menisci. The stability types are those limited by volume or pressure, in conjunction with limitation by the size of the supporting solid surface or the angle of contact. The three forms of menisci are pendant drops, sessile drops and rod-in-free-surface menisci. Detailed stability criteria are given for each of the twelve different combinations of stability type and meniscus form. The stability criteria of this study are all derived by numerical interpolation methods applied to the tables of equilibrium meniscus shapes - they are thus theoretical. Where possible they have been compared with experiment and with other studies, and are found to predict critically stable states with an accuracy greater than that likely to be found in the normal course of experiments.
Ob/ob Mouse Livers Show Decreased Oxidative Phosphorylation Efficiencies and Anaerobic Capacities after Cold Ischemia (2014)

Steatotic livers have impaired baseline aerobic and anaerobic capacities compared to lean livers, and mitochondrial function indices decrease particularly from after 5 hours of cold preservation. These data provide a mechanistic basis for the clinical recommendation of shorter cold storage durations in steatotic donor livers.
Antimicrobial Cellobiose Dehydrogenase-Chitosan Particles (2015)

Increasing prevalence of chronic wounds and microbial infection constitute a severe health challenge. The situation is further complicated by emerging multidrug resistance making the treatment of infections increasingly difficult. Here, a novel antimicrobial system based on in situ release of hydrogen peroxide (H2O2) by cellobiose dehydrogenase (CDH) immobilized on chitosan (CTS) particles is described. Covalent immobilization using carbodiimide coupling lead to a higher amount of protein immobilized on CTS (104 μg CDH/mg CTS) when compared to noncovalent immobilization, which, however, showed highest recovery of CDH activity (0.01 U/mg CTS). The CDH-CTS in situ generated H2O2 completely inhibited growth of Escherichia coli and Staphylococcus aureus over a period of 24 h. This resilient antimicrobial system represents a novel strategy for preventing infection with potential application in counteracting microbial colonization of chronic wounds.
Allorecognition of Class-II Major Histocompatibility Complex Molecules May Be Influenced by Tap1 and Tap2 Peptide Transporters (1993)

Conference Abstract| July 01 1993 Allorecognition of Class-II Major Histocompatibility Complex Molecules May Be Influenced by Tap1 and Tap2 Peptide Transporters P. Cramichael; P. Cramichael 1Department of Immnology, Royal Postgraduate Mechical school, Du Cane Road, London W12 Search for other works by this author on: This Site PubMed Google Scholar L.A. Kerr; L.A. Kerr ‡Department of Immunogenetics, Imperial Cancer Research Fund, Lincoln's Inn Field, London W1 Search for other works by this author on: This Site PubMed Google Scholar A. Kelly; A. Kelly ‡Department of Immunogenetics, Imperial Cancer Research Fund, Lincoln's Inn Field, London W1 Search for other works by this author on: This Site PubMed Google Scholar G. Lowbardi; G. Lowbardi 1Department of Immnology, Royal Postgraduate Mechical school, Du Cane Road, London W12 Search for other works by this author on: This Site PubMed Google Scholar A. Zeigler; A. Zeigler ‡Department of Immunogenetics, Imperial Cancer Research Fund, Lincoln's Inn Field, London W1 Search for other works by this author on: This Site PubMed Google Scholar J. Trowsdale; J. Trowsdale ‡Department of Immunogenetics, Imperial Cancer Research Fund, Lincoln's Inn Field, London W1 Search for other works by this author on: This Site PubMed Google Scholar R.I. Lechker R.I. Lechker 1Department of Immnology, Royal Postgraduate Mechical school, Du Cane Road, London W12 Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1993) 85 (s29): 11P. https://doi.org/10.1042/cs085011P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation P. Cramichael, L.A. Kerr, A. Kelly, G. Lowbardi, A. Zeigler, J. Trowsdale, R.I. Lechker; Allorecognition of Class-II Major Histocompatibility Complex Molecules May Be Influenced by Tap1 and Tap2 Peptide Transporters. Clin Sci (Lond) 1 July 1993; 85 (s29): 11P. doi: https://doi.org/10.1042/cs085011P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1993 The Biochemical Society and the Medical Research Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Energy Consumption Analysis of D2D Communication in 5G Systems: Latest Advances in 3GPP Standardization (2017)

Device-to-device (D2D) communication is an essential part of the future fifth generation (5G) system that can be seen as &ldquo;network of networks&rdquo;, consisting of multiple seamlessly integrated radio access technologies (RATs). Public safety communications, autonomous driving, social-aware networking, and infotainment services are example use cases of D2D technology. High data rate communications and use of several active air interfaces in the described network create energy consumption challenges for both base stations and the end user devices. In this paper, we review the status of 3GPP standardization and define a set of application scenarios. We use the recent models of 3GPP Long Term Evolution (LTE) and WiFi interfaces in analyzing the power consumption both from the infrastructure and user device perspectives. The results indicate that the number of active interfaces should be minimized.
Magnetic Resonance Imaging of Self-Assembled Biomaterial\nScaffolds (2016)

Current interest in biomaterials for tissue engineering and drug delivery applications have spurred\nresearch into self-assembling peptide amphiphiles (PAs). Nanofiber networks formed from self-assembling PAs can be used as biomaterial scaffolds with the advantage of specificity by the\nincorporation of peptide-epitopes. Imaging the materials noninvasively will give information as to\ntheir fate in vivo. We report here the synthesis and in vitro MR images of self-assembling peptide\namphiphile contrast agents (PACAs) that form nanofibers. At 400 MHz using a 0.1 mM Gd(III)\nconjugate of the PA we observed a T<sub>1</sub> three times that of a control gel. The PA derivative was doped\ninto various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as\nimaged by MRI.
ChemInform Abstract: A Practical, Highly Enantioselective Synthesis of the Taxol Side Chain via Asymmetric Catalysis. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electroencephalographic Monitoring of Brain Wave Activity During Laparoscopic Surgical Simulation to Measure Surgeon Concentration and Stress: Can the Student Become the Master? (2015)

EEG brain activity in more experienced surgeons reveals a significant increase in concentration levels with a decrease in stress during simulated laparoscopic tasks compared with novices. This information may correlate with increased proficiency as well as provide objective feedback of progress along the learning curve with the MUSE SDK.
Coherent vertical electron transport and interface roughness effects in AlGaN/GaN intersubband devices (2015)

We investigate electron transport in epitaxially grown nitride-based resonant tunneling diodes (RTDs) and superlattice sequential tunneling devices. A density-matrix model is developed, and shown to reproduce the experimentally measured features of the current–voltage curves, with its dephasing terms calculated from semi-classical scattering rates. Lifetime broadening effects are shown to have a significant influence in the experimental data. Additionally, it is shown that the interface roughness geometry has a large effect on current magnitude, peak-to-valley ratios and misalignment features; in some cases eliminating negative differential resistance entirely in RTDs. Sequential tunneling device characteristics are dominated by a parasitic current that is most likely to be caused by dislocations; however, excellent agreement between the simulated and experimentally measured tunneling current magnitude and alignment bias is demonstrated. This analysis of the effects of scattering lifetimes, contact doping and growth quality on electron transport highlights critical optimization parameters for the development of III–nitride unipolar electronic and optoelectronic devices.
Gemin B and C, dimeric ellagitannins from Geum Japonicum. (1982)

Two new dimeric ellagitannins, gemin B (2) and C (3), and a monomeric tannin, gemin D (4), have been isolated from Geum japonicum. Their structures were elucidated on the basis of NMR analysis and partial hydrolysis. Gemin D was isolated also from Camellia japonica.
Targeted Depletion and Inhibition of Activated T Lymphocytes with SGN-70, a Humanized Antibody Specific for the Activation Antigen CD70. (2006)

Abstract CD70 (CD27L) is a member of the tumor necrosis factor superfamily that is predominantly expressed on activated lymphocytes and is important for generation of B and T memory and effector responses. High levels of CD70 are also found on chronically activated T cells and lymphocytes in patients with autoimmune disorders. Blockade of CD70 interaction with its receptor has been shown to inhibit the onset of experimental autoimmune encephalomyelitis and cardiac allograft rejection in mice. We have engineered a humanized anti-CD70, SGN-70, that mediates Fc-dependent antibody effector functions and blocks binding of CD70 to its receptor. In this report we show that SGN-70 inhibits co-stimulation of T lymphocytes, and selectively depletes CD70+ activated T cells. Depletion of antigen-specific T cells by SGN-70 was demonstrated using CD8+ T cells specific for a peptide (M58-66) derived from the influenza A matrix protein M1. Stimulation of peripheral blood mononuclear cells with the M1 peptide markedly induced CD70 expression within a discrete expanding of M1 peptide-specific CD8+Vβ17+ T cell subset. Treatment of peptide-stimulated cultures with SGN-70 (0.01–1 μg/mL) decreased the number of CD70+CD8+Vβ17+ cells by >80%. This depletion was dependent on the activity of CD16+ cells within the culture since blocking CD16 completely eliminated the depleting effect of SGN-70. Non-activated Vβ17 negative cells were not affected by SGN-70 and were functionally equivalent to untreated control cultures in subsequent response to mitogenic re-stimulation. Together, these data demonstrate the capacity of SGN-70 to selectively target activated cells and its potential to limit expansion of antigen-specific T lymphocytes. Thus, SGN-70 may have therapeutic potential to target T cell-mediated autoimmune and inflammatory diseases.
TAVR in Nonagenarians (2016)

Invasive and/or expensive interventions in the very elderly are controversial. Researchers used the national Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry and Medicare data to compare outcomes of transcatheter aortic valve replacement (TAVR) in 3773 patients aged ≥90 (median age, 92; 16% of registry population) and 20,252 patients aged <90 (median age, 82).

All were treated with commercial devices. The nonagenarians were more liable to be female and to have fewer comorbidities than the …
Critical Issues in the Application and Evaluation of a Corrosion Prediction Model for Oil and Gas Systems (2003)

Abstract Developing computer-based problem solving models that predict corrosion in oil and gas systems is a complex task, requiring integration of multiple scientific and engineering disciplines. In addition to capturing and characterizing the role of primary environmental, fluid flow and metallurgical variables contributing to the mechanisms of corrosion, it is necessary to validate the performance of the model within the context of field experience. This paper describes the evolution of a corrosion prediction computer model for oil and gas systems in terms of critical parameters such as system pH, CO2, H2S, temperature and fluid dynamics factors and details a methodology wherein the model is applied to assessing corrosion for a real life field application.
Cardiorespiratory fitness and cognitive function in midlife: Neuroprotection or neuroselection? (2015)

We found no evidence for a neuroprotective effect of cardiorespiratory fitness as of midlife. Instead, children with better cognitive functioning are selecting healthier lives. Fitness interventions may enhance cognitive functioning. However, observational and experimental studies testing neuroprotective effects of physical fitness should consider confounding by neuroselection.
Direct 99mTc-labelling of surfactant protein B, a lipophilic protein, using the Tc(I) organometallic [99mTc(CO)3]+-core (2000)

s: Abstracts of an International Conference on Peptide Radiopharmaceuticals in Diagnosis and Therapy Rome, Italy, 25-28 May 2000: Poster Presentations
Short-pulse photolytic iodine laser (2000)

A compact, short pulse photolytic iodine laser (PIL) system designed for use as a source in Raman conversion experiments is described. The single-shot, flashlamp-pumped laser outputs 10 Joules in a 3 microsecond(s) FWHM pulse at a wavelength of 1.315 micrometer and uses n-C<SUB>3</SUB>F<SUB>7</SUB>I as the renewable laser fuel. Laser design and performance characteristics are presented.
ChemInform Abstract: Diketene and Acetoacetates (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimization of local methylprednisolone delivery to inhibit inflammatory reaction and neointimal hyperplasia of coated coronary stents. (2002)

Polymer coating can optimize the surface characteristics of metallic coronary stents and serve as a vehicle for local drug delivery. Major problems, however, include the lack of biocompatibility of the polymers used and the limited amount of drug that can be loaded onto the stent. Stainless-steel stents were spray-coated or spray-coated combined with a barrier coating using a fluorinated polymethacrylate PFM-P75 impregnated with different methylprednisolone concentrations. When spray-coated with highly concentrated methylprednisolone ( 33%) fluorinated polymethacrylate PFM-P75, the surface became progressively more rough. Adding a barrier coating, however, could decrease these surface irregularities of methylprednisolone-loaded PFM-P75 spray-coated stents. In vitro, most of the methylprednisolone was released in the first 48 hours. A barrier coating could dramatically slow down the drug release from 80% to 13% during the first 48 hours. Histomorphometric analysis showed that the inflammatory response and neointimal hyperplasia of methylprednisolone-loaded stents were lower than in control stents. Neointimal hyperplasia of methylprednisolone-loaded PFM-P75 stents spray-coated with a barrier coating was decreased compared to the non-barrier-coated methylprednisolone-loaded stents. In conclusion, spray coating enables the use of high methylprednisolone concentrations. A barrier coating could significantly slow down the methylprednisolone release. Methylprednisolone-loaded PFM-P75-coated stents could significantly inhibit the inflammatory response and neointimal hyperplasia. The response to methylprednisolone was related to the dose used and the release time of the drug.
Preparation and reactions of 4-(trimethylsilyl)indole (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and reactions of 4-(trimethylsilyl)indoleDaniel Dauzonne, Ian A. O'Neil, and Alain RenaudCite this: J. Org. Chem. 1984, 49, 23, 4409–4415Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/jo00197a016https://doi.org/10.1021/jo00197a016research-articleACS PublicationsRequest reuse permissionsArticle Views1625Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Solid-state conformation of anti-human immunodeficiency virus type-1 agents: Crystal structures of three 3'-azido-3'-deoxythymidine analogs (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-state conformation of anti-human immunodeficiency virus type-1 agents: Crystal structures of three 3'-azido-3'-deoxythymidine analogsPatrick. Van Roey, Jeffrey M. Salerno, William L. Duax, Chung K. Chu, Moon K. Ahn, and Raymond F. SchinaziCite this: J. Am. Chem. Soc. 1988, 110, 7, 2277–2282Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ja00215a044https://doi.org/10.1021/ja00215a044research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Dynamic renormalization group analysis of propagation of elastic waves in two-dimensional heterogeneous media (2008)

We study localization of elastic waves in two-dimensional heterogeneous solids with randomly distributed Lam\'e coefficients, as well as those with long-range correlations with a power-law correlation function. The Matin-Siggia-Rose method is used, and the one-loop renormalization group (RG) equations for the coupling constants are derived in the limit of long wavelengths. The various phases of the coupling constants space, which depend on the value $\ensuremath{\rho}$, the exponent that characterizes the power-law correlation function, are determined and described. Qualitatively different behaviors emerge for $\ensuremath{\rho}<1$ and $\ensuremath{\rho}>1$. The Gaussian fixed point (FP) is stable (unstable) for $\ensuremath{\rho}<1$ $(\ensuremath{\rho}>1)$. For $\ensuremath{\rho}<1$, there is a region of the coupling constants space in which the RG flows are toward the Gaussian FP, implying that the disorder is irrelevant and the waves are delocalized. In the rest of the disorder space, the elastic waves are localized. We compare the results with those obtained previously for acoustic wave propagation in the same type of heterogeneous media and describe the similarities and differences between the two phenomena.