gebhart/patrepeval huggingface dataset:
A sigma-delta ADC with a built-in anti-aliasing filter for Bluetooth receiver in 130nm digital process (2004)

A discrete-time sigma delta ADC is presented, that filters and decimates by two the input data samples, while providing amplification in its input sampling stage. This compact architecture allows operating preceding blocks at twice the ADC's clock frequency, thus improving the noise performance of the receive channel. The presented approach has been validated and incorporated in a commercial Bluetooth receiver IC, realized in a 1.5 V, 130 nm digital CMOS process.
Chapter 5: Nonlinear Systems with Input Delay (2013)

In this chapter we introduce the concepts of nonlinear predictor feedback and nonlinear infinite-dimensional backstepping transformation. One of the main challenges in developing predictor feedback designs for nonlinear plants is the determination of an implementable form for the future values of the state. Having determined the predictor state, the control law is then obtained by replacing the state in a nominal state feedback law (which stabilizes the delay-free plant) by the state's predictor. In addition, another major obstacle in designing globally stabilizing control laws for nonlinear systems with long input delays is the finite escape phenomenon. The input delay may be so large that the control signal cannot reach the plant before its state escapes to infinity. Therefore, in this chapter we assume that the plant is forward complete, that is, for every initial condition and every bounded input signal the corresponding solution is defined for all times. The last ingredient that one needs for achieving global stabilization is the existence of a (possibly time-varying) feedback law that globally stabilizes the delay-free plant. We start in Section 5.1 with the design of the nonlinear predictor feedback. In Section 5.2 we introduce the nonlinear infinite-dimensional backstepping transformation, which allows the construction of a Lyapunov functional for the closed-loop system, which we use to prove stability of the closed-loop system in Section 5.3.
Broadband quasi-phase-matched second-harmonic generation in MgO-doped periodically poled LiNbO_3 at the communications band (2002)

A novel scheme for broadband second-harmonic generation was developed with type I quasi phase matching by use of an off-digital nonlinear optical coefficient d(31) . This was achieved by matching of the group velocities of the second harmonic and the fundamental, while the phase velocities were quasi phase matched. The desired group-velocity dispersion could be obtained with LiNbO(3) doped with 5 mol. % of MgO. Efficient second-harmonic generation with a bandwidth of 52 nm was obtained for the fundamental wavelength centered at 1566 nm in MgO-doped periodically poled LiNbO(3) , compared with a bandwidth of 1.3 nm for the conventional scheme using d(33) . Efficient frequency doubling of an ultrafast pulse is expected without group-velocity walk-off or pulse distortion.
Recalcitrant leg ulcer due to mixed connective tissue disease. (2006)

We present a 28-year-old woman with mixed connective tissue disease (MCTD) complicated by a recalcitrant longstanding leg ulcer, which responded to complex therapy with local polydine, systemic ciprofloxacin, iloprost, enoxaparin and aspirin. Cyclophosphamide pulse therapy and corticosteroids controlled the systemic inflammation but failed to heal the leg ulcer. We considered a rationale of complex therapy for the leg ulcer on a basis of pathogenesis and complications of MCTD.
Note on conventions (2001)

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Neurotoxic properties of a serotonin oxidation product: possible role in Alzheimer's disease. (1989)

Properties of a partially oxidized form of serotonin (5-HT), 4,5-diketotryptamine (4,5-DKT), synthesized by electrochemical oxidation of 5-HT, were investigated. Administration of 4,5-DKT into the lateral ventricles (i.c.v.) of rats resulted in cell death and terminal degeneration in entorhinal, insular, and posterior cingulate cortices, and in the CA1, CA3 and dentate gyrus sectors of hippocampus. Furthermore, i.c.v. administration of 4,5-DKT resulted in a significant depletion of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels in prefrontal cortex, striatum and hippocampus. 4,5-DKT injection into cingulate and hippocampal cortices resulted in cell death and terminal degeneration in these structures. In brain fragment perfusion and incubation experiments, 4,5-DKT increased dose dependently 5-HT efflux from rat hippocampus and striatum. The efflux of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid from striatum was unaffected. In hippocampal preparations, fluoxetine decreased 4,5-DKT-stimulated efflux of 5-HT by 24%, and pargyline did not affect it. In vitro, 4,5-DKT bound covalently to nucleophilic -SH groups in glutathione and mercaptoethanol and the binding was blocked by N-ethyl-maleimide. 4,5-DKT bound selectively to purified guanine nucleotide binding proteins, and inhibited pertussis toxin-catalyzed ribosylation at 1nM-1 microM concentrations. Analysis of cerebrospinal fluid (CSF) by a 16-channel high pressure liquid chromatography with coulometric detection did not confirm presence of 4,5-DKT in Alzheimer CSF, but detected several peaks, significantly different in control and Alzheimer CSF, which were caused by unknown compounds.
Board-to-board free-space optical interconnects of bus architecture (1996)

This paper presents the concepts of a board-to-board free space optical interconnection scheme that will support a bus architecture. While the technology required to implement this optical scheme is very compatible with existing electronic packaging technologies, it promises to be able interconnect many more boards together without serious impedance matching or termination problems encountered by electrical interconnects at high speed. Experimental demonstration of the optical scheme is in progress.
Head Injury (2021)

Head trauma is the most common cause of death and permanent disability following trauma. Blunt head injury is usually the result of motor vehicle collisions, auto versus pedestrian collisions, or falls from significant heights. Gunshot wounds cause the vast majority of penetrating head injuries, although stab wounds and impalement injuries may also be seen.
Abstract 3515: RRx-001: A double action systemically non-toxic epigenetic agent for cancer therapy (2015)

Abstract RRx-001 (also known as ABDNAZ, 1-bromoacetyl-3,3-dinitroazetidine) is a novel aerospace-derived compound that demonstrated anticancer activity in the absence of systemic toxicities in a recent phase I clinical trial and is now in phase II studies. With a highly energetic heterocyclic scaffold, RRx-001 generates reactive oxygen species (ROS) and nitric oxide (NO), modulates intracellular redox status, and triggers caspase-independent apoptosis in cancer cells. Here we showed that RRx-001 as a single chemical entity regulates at least two epigenetic processes, histone acetylation and DNA demethylation. Specifically, RRx-001 at its therapeutic concentrations (0.5-5 μM) significantly decreased global DNA methylation, i.e., 5-methylcytosine levels, in SCC VII tumor cells as determined by ELISA. Consistently, treatment of SCC VII cells with 0.5-5 μM RRx-001 significantly decreased Dnmt1 and Dnmt3a protein expression in a dose- and time-dependent manner as determined by Western blots. In addition, global methylation profiling using Illumina Infinium HumanMethylation450 BeadChip® identified differentially methylated genes in SCC VII cells treated with 0.5, 2, and 5 μM RRx-001 compared to control cells. Of 111 genes demethylated by RRx-001 identified using GenomeStudio software, methylation levels of 3 genes (FAM20C, STON1-GTF2A1L and TRIAP1) were decreased by at least 2-fold across all three concentrations of RRx-001. Validation of these changes by pyrosequencing is underway. Pathway enrichment analysis by IPA suggested that RRx-001 demethylated genes involved in hepatic fibrosis, G protein signaling, leucine degradation and remodeling of epithelial adherens junctions. Moreover, RRx-001 at 2 μM significantly increased global acetylated histone H3 and H4 levels in SCC VII cells after 24 hour treatment as determined by a fluorometric assay, suggesting that RRx-001 regulates global acetylation in cancer cells. Western blot analysis also showed significant increases in acetylated histone H3 and H4 levels in SCC VII cells in a dose and time-dependent manner after RRx-001 treatment. Taken together, our results demonstrated that, in contrast to the traditional “one drug one target” paradigm, RRx-001 has multi(epi)target features, which contribute to its anticancer activity. Citation Format: Hongjuan Zhao, Shoucheng Ning, Jan Scicinski, Bryan Oronsky, Susan Knox, Donna M. Peehl. RRx-001: A double action systemically non-toxic epigenetic agent for cancer therapy. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3515. doi:10.1158/1538-7445.AM2015-3515
Diagnosis of High‐Grade Osteosarcoma by Radiology and Cytology: A Retrospective Study of 52 Cases (2004)

The diagnostic value of combined radiology and fine needle aspiration cytology (FNAC) was retrospectively assessed in a consecutive series of 52 patients with high-grade osteosarcoma. The series was divided into typical and atypical osteosarcomas according to radiological features and site. Thirty-two of 33 radiologically typical osteosarcoma cases were correctly diagnosed by cytology; one lesion was diagnosed as sarcoma NOS. Nineteen osteosarcoma cases were radiographically atypical. Six of these were diagnosed as osteosarcoma and another six as sarcoma NOS. In three cases another type of sarcoma was suggested. One case was falsely classified as benign. FNAC of three cases were non-diagnostic. Overall, the diagnostic difficulties pertained to the radiologically atypical cases. Notably, four of these also posed considerable difficulties in the histopathological assessment prompting external consultation. Our study suggests that open biopsy can be obviated in high-grade osteosarcomas exhibiting typical radiological features, i.e., in two-thirds.
Über die Umsetzung von α‐Chlor‐α‐äthylmercapto‐ketonen mit Kaliumrhodanid. Ein neuer Weg zu Oxazolthionen‐(2) (1958)

Abstract Bei der Umsetzung der aus Diazoketonen und Äthylschwefelchlorid leicht zugänglichen α‐Chlor‐α‐äthylmercapto‐ketone mit Kaliumrhodanid entstehen nicht, wie erwartet, Verbindungen der Thiazolreihe, sondern Derivate des Oxazolthions‐(2). Ihre Struktur wurde auf Grund von IR‐Spektren und durch ihre hydrolytische Überführung in 4‐Oxo‐2‐thion‐oxazolidine und 2.4‐Dioxo‐oxazolidine bewiesen.
B19 Knowledge discovery of ball end mill condition derived from catalog mining system (2012)

It is necessary to construct a system that helps engineer to decide the tools and cutting conditions for unskilled engineers. We aim to extract rules from catalogs by using data mining to help engineers to decide about cutting conditions. We used variable cluster analysis and the K-means method to find tool shape parameters that had a linear relationship with ball end milling conditions listed in the catalog. We used the response surface method and significant tool shape parameters obtained by clustering to derive ball end milling condition. The aim of our research was to do the experiment and extract new knowledge by applying data mining techniques to the machine tool makers' catalogs.
Visual Hallucinations as Incidental Negative Effects of Virtual Reality on Parkinson’s Disease Patients: A Link with Neurodegeneration? (2015)

We followed up a series of 23 Parkinson's disease (PD) patients who had performed an immersive virtual reality (VR) protocol eight years before. On that occasion, six patients incidentally described visual hallucinations (VH) with occurrences of images not included in the virtual environment. Curiously, in the following years, only these patients reported the appearance of VH later in their clinical history, while the rest of the group did not. Even considering the limited sample size, we may argue that VR immersive systems can induce unpleasant effects in PD patients who are predisposed to a cognitive impairment.
Non-Cylindrical Blade Geometry Definition (1997)

This paper presents various methods for describing propeller blade geometry using non-cylindrical blade sections. The coordinates of these sections are easily determined from the traditional set of radially-varying geometric parameters such as chord, camber, thickness, pitch, skew, and rake, in addition to a set of axisymmetric surfaces on which the blade sections are generated. Basic equations and numerical procedures are presented for various methods. One particular method, which uses constant pitch angle as a basis for generating the section nose-tail line, is recommended over the others since it is a reasonable compromise between simplicity and allowing for rational interpretation of the section geometric parameters. Some practical examples are provided.
Endovascular needle injection of cholesteryl linoleate into the arterial wall produces complex vascular lesions identifiable by intravascular ultrasound: early development in a porcine model of vulnerable plaque (2005)

The intramural deposition of cholesteryl linoleate results in the development of complex, lipid-containing inflammatory lesions in less than 4 weeks. These lesions are already identifiable by IVUS at 2 weeks and colocalize with histologic findings. Further development of this model may allow the validation of technologies designed to detect and treat high-risk atherosclerotic lesions.
Benefits of Employing Metasurfaces on the Design of a Microwave Brain Imaging Scanner (2021)

The demand for personalized and non-invasive technologies for diagnostics of brain-related diseases is a challenge involving multiple research fields. In this context, emerging electromagnetic (EM) techniques are receiving increased attention [1] . Among these techniques, microwave imaging (MWI) has the potential to address specific clinical needs such as intra-cerebral hemorrhage (ICH) detection and monitoring. The success of an MWI brain scanner is strongly dependent on its hardware characteristics. For instance, to achieve a device capable of detecting a hemorrhage inside the brain, array of antennas immersed into a coupling medium are typically used to transmit microwaves in the 0.5–1.5 GHz frequency range into the brain tissue and receive the resulting scattered signal [2] . In addition, our previous studies have shown that metasurface (MTS) structures can be used to enhance transmission and couple the incident power into the region of interest [3] .
Über die Elimination des Diffusionspotentials zwischen zwei verdünnten wässerigen Lösungen durch Einschalten einer konzentrierten Chlorkaliumlösung (1905)

Article Über die Elimination des Diffusionspotentials zwischen zwei verdünnten wässerigen Lösungen durch Einschalten einer konzentrierten Chlorkaliumlösung was published on August 1, 1905 in the journal Zeitschrift für Physikalische Chemie (volume 53U, issue 1).
Analytical and Experimental Investigation of Diffusers for VSTOL Thrust-Augmenting Ejectors (1979)

A THRUST-AUGMENTING ejector is a pneumatic device in which the direct transfer of kinetic energy from a primary jet to air drawn in from the atmosphere (via turbulent mixing) produces an increase in the primary thrust. For VSTOL applications, the allowable length of the ejector is small and the diffuser (sidewall flap) design has an important effect on augmentor performance. It was experimentally demonstrated that improved augmentation can be obtained with cambered flaps or straight flaps with tabs. Various combinations of tab blowing and upstream Coanda blowing were experimentally and analytically examined with centerbody and total nozzle area held constant. Nomenclature A0 = primary nozzle area (center jet + Coanda + tab) + boundary-layer control (BLC)
The Racemization of Alkyl Hydrogen Sulfates in Sulfuric Acid<sup>1</sup> (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Racemization of Alkyl Hydrogen Sulfates in Sulfuric Acid1N. C. Deno and Melvin S. NewmanCite this: J. Am. Chem. Soc. 1951, 73, 5, 1920–1923Publication Date (Print):May 1, 1951Publication History Published online1 May 2002Published inissue 1 May 1951https://pubs.acs.org/doi/10.1021/ja01149a005https://doi.org/10.1021/ja01149a005research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation (2019)

We developed a reporter system that can be used in a dual manner in visualizing mature osteoblast formation. The system is based on a helper-dependent adenoviral vector (HDAdV), in which a fluorescent protein, Venus, is expressed under the control of the 19-kb human osteocalcin (OC) genomic locus. By infecting human and murine primary osteoblast (POB) cultures with this reporter vector, the cells forming bone-like nodules were specifically visualized by the reporter. In addition, the same vector was utilized to efficiently knock-in the reporter into the endogenous OC gene of human induced pluripotent stem cells (iPSCs), by homologous recombination. Neural crest-like cells (NCLCs) derived from the knock-in reporter iPSCs were differentiated into osteoblasts forming bone-like nodules and could be visualized by the expression of the fluorescent reporter. Living mature osteoblasts were then isolated from the murine mixed POB culture by fluorescence-activated cell sorting (FACS), and their mRNA expression profile was analyzed. Our study presents unique utility of reporter HDAdVs in stem cell biology and related applications.
Intracerebral Implantation of Autologous Peripheral Blood Stem Cells in Stroke Patients: A Randomized Phase II Study (2014)

In our previous study, intracerebral implantation of peripheral blood stem cells (PBSCs) improved functional outcome in rats with chronic cerebral infarction. Based on this finding, a randomized, single blind controlled study was conducted in 30 patients [PBSC group (n = 15) and control group (n = 15)] with middle cerebral artery infarction confirmed on a T2-weighted MRI 6 months to 5 years after a stroke. Only subjects with neurological deficits of intermediate severity based on the National Institute of Health Stroke Scale (NIHSS; range: 9-20) that had been stable for at least 3 months were enrolled. Those in the PBSC group received subcutaneous G-CSF injections (15 µg/kg/day) for 5 consecutive days, and then stereotaxic implantation of 3-8 × 10(6) CD34(+) immunosorted PBSCs. All 30 patients completed the 12-month follow-up. No serious adverse events were noted during study period. Improvements in stroke scales (NIHSS, ESS, and EMS) and functional outcomes (mRS) from baseline to the end of the 12-month follow-up period were significantly greater in the PBSC than the control group. The fiber numbers asymmetry (FNA) scores based on diffusion tensor image (DTI) tractography were reduced in every PBSC-treated subject, but not in the control group. Reduction in the FNA scores correlated well with the improvement in NIHSS. Furthermore, a positive motor-evoked potential (MEP) response by transcranial magnetic stimulation (TMS) appeared in 9 of the 15 subjects in the PBSC group. This phase II study demonstrated that implantation of autologous CD34(+) PBSC was safe, feasible, and effective in improving functional outcome.
Multi-scale spatial variation in stable isotope and fatty acid profiles amongst temperate reef species: implications for design and interpretation of trophic studies (2010)

Stable isotopes of carbon and nitrogen and fatty acid analyses are increasingly being used in combination to determine the trophic structure of marine systems. For stable isotopes, the variability in carbon and nitrogen isotopic signatures has long been recognised and has been characterised for some taxa. Whilst it is known that metabolic processes may influence fatty acid profiles, the spatial variability of fatty acid profiles has not been documented. Understanding at what scale these 2 biochemical tracers vary, and if the scale of variability corresponds between tracers, is crucial for the correct design and interpretation of combined tracers in trophic studies. This study is the first to examine spatial variability in fatty acid profiles per se, and in combination with stable isotope ratios in the same organisms at multiple spatial scales. We used a spatially hierarchical design which sampled across broad geographic regions, reefs within regions, and also between different parts of macroalgal plants common on temperate reefs. For stable isotopes of carbon and nitrogen, variability was greatest at intermediate spatial scales (between locations within regions, and sites within locations). In contrast, fatty acid profiles showed the greatest variation amongst individual replicates of lobster, abalone and macroalgae. This study demonstrates that for the increasing number of trophic studies using combined biochemical tracers, sampling design should cater to the differences in the variability of each tracer technique and allocate sampling accordingly.
Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration (2009)

1. Martini, F. J. et al. 2009. Development doi: 10.1242/dev.025502
 [OpenUrl][1][Abstract/FREE Full Text][2]

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Electroacoustic transducers using piezoelectric polyvinylidenefluoride films (1979)

We have theoretically and experimentally analyzed microphones with cylindrical and spherical polyvinylidenefluoride diaphragms. In particular, the response of such microphones to airborne sound and to vibrations as a function of diaphragm geometry, acoustic impedance of the surrounding medium, coupling volume, and excitation was calculated. Most importantly, a relationship between the output voltage at low frequencies and the position of resonant frequencies was established. There is good agreement between calculated and measured frequency responses.