gebhart/patrepeval huggingface dataset:
Impact of Anakinra Treatment on Cytokine and Lymphocytes/ Monocytes Profile of an Erdheim-Chester Patient (2014)

Our results suggest that IL6 may be a marker of early treatment response of ECD patients treated with anakinra.
Factors Affecting Storage Stability of Vitamin A, Riboflavin, and Niacin in a Broiler Diet Premix (1986)

The effects of minerals, temperature, and the nature and degree of diluent on the stabilities of vitamin A, riboflavin, and niacin in a broiler diet premix were studied over a 16- to 27-week storage period. Vitamin A was the least stable of the three vitamins. Presence or absence of minerals did not make a significant difference in the stability of vitamin A in the premix, but higher storage temperatures increased the rate of vitamin A destruction. Destruction of vitamin A was greatest when ground sorghum was used as a diluent and least when the diluent was ground corn cobs or rice hulls. Stability of vitamin A in the premix appeared to increase as the degree of dilution increased. The presence of trace minerals in the premix adversely affected riboflavin stability, and higher storage temperatures accelerated riboflavin loss. Type of diluent used was less significant in riboflavin stability than it was for vitamin A stability. Ground corn cobs were the best diluent for riboflavin, with no significant difference among ground corn, ground sorghum, and ground rice hulls. Niacin was considerably more stable than riboflavin or vitamin A, but the presence of minerals and high temperature significantly decreased niacin stability. Ground corn cobs were the best diluent with respect to niacin stability, which was also better at higher dilution levels.
Relations of weight-average molecular weights and the thermal properties ofN-cyclohexyl maleimide-methyl methacrylate (1998)

N-cyclohexyl maleimide (CHMI) was used to copolymerize with methyl methacrylate (MMA) by a suspension copolymerization method to produce heat-resistant poly(MMA) (PMMA) in this article. The copolymers were synthesized by changing the weight fractions of azobisisobutyronitrile (AIBN) and dodecanethiol (DDM), while the weight ratio of CHMI to MMA was defined. The effects of the weight fractions of AIBN and DDM on weight-average molecular weight (Mw) were studied. Meanwhile, relations between Mw and the glass transition temperature (Tg) and decomposition temperature (Td) and Mw and the melt flow index (MFI) were described. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 70: 2001–2005, 1998
[The first and second polar bodies in mouse oogenesis]. (1995)

Using light and electron microscopy, we studied several characteristics of the interphase nuclei and mitotic chromosomes in embryonic cells Cyclops kolensis (Lill) before and after chromatin diminution. We detected the reduction of one of the two nucleoli in somatic cells resulting from chromatin diminution. However, the ratio of the total diameter of the nucleoli to the diameter of the nucleus or to the diameter of the cell remains unchanged. Granules of the chromatin to be eliminated become visible in somatic cells of the C. kolensis embryos at the interphase of the fourth cleavage division. The structure of interphase nuclei and mitotic chromosomes of somatic cells of C. kolensis embryos is different before and after chromatin diminution. Possible mechanisms underlying these differences are discussed.
The influence of design on the transmission of torque across knee prostheses. (1978)

Knee prostheses of eight different designs were tested experimentally to determine the axial torque necessary to rotate the tibial component relative to the femoral component with the prosthesis positioned at or near full extension. The results represent transmitted torque as a function of axial rotation. For six designs, the transmitted torque was 11.3 newton-meters (100 inch-pounds) or greater at 6 degrees of rotation, with an axial load of 1556.8 newtons (350 pounds). These prostheses either had close conformation between femoral and tibial components, or were mechanically linked. In these prostheses, the geometry of the articulating surfaces was the primary determinant of torque. For the other two types, under similar loading conditions the transmitted torques were 2.5 newton-meters (twenty-two inch-pounds) at 6 degrees of rotation. These prostheses were designed to allow greater freedom for rotation, and hence for them the primary determinant of torque was friction between the articulating surfaces. The predictive value of this torque characteristic relative to the incidence of loosening will have to be determined by comparison with clinical experience.
Characterization of the Stoichiometry of HMGA1/DNA Complexes (2013)

High-mobility group A1 (HMGA1) non-histone chromatin architectural transcription factors regulate gene expression, embryogenesis, cell differentiation, and adaptive immune responses by binding DNA and other transcription factors. HMGA1 has also been shown to be highly over-expressed in many human cancers and is considered to be a valuable cancer biomarker. Elevated HMGA1 expression levels also make cancer cells resistant to chemotherapy. Here, HMGA1/DNA complex formation was investigated using electrophoretic mobility shift assays (EMSA). Collectively, the EMSA results indicated that full length HMGA1 mixed with DNA containing three AT-hook binding sites formed four distinct HMGA1/DNA complexes ranging in stoichiometry from 1:2 to 3:1 in HMGA1:DNA ratio. The data indicated that the distribution of complexes with different HMGA1 to DNA stoichiometries depended on the molar ratio of HMGA1 to DNA in solution, which could have significant biological implications given that HMGA1 is highly over-expressed in human cancer cells. The two naturally occurring isoforms of HMGA1, HMGA1a and HMGA1b, the latter containing an 11 amino acid deletion between the first and second AT-hooks, were observed to have slightly different DNA binding profiles. Finally, HMGA1 binding affinity to DNA was found to be influenced by the DNA A:T segment sequence context, with higher specificity be observed in HMGA1 binding to TnAn segments, which have two local minor groove minima on either side of the TpA step, compared to An:Tn segments, which have a single minor groove minimum at the 3' end of the An run, implying AT-hook binding favors narrow minor groove structure.
Synergistic effect of spices in a decoction regulates the energy metabolism in liver cancer cells (2016)

Lactic acid fermentation and not oxidative phosphorylation is reported to be one of the major bioenergetics mechanisms by which cancer cells thrive and proliferate with such rapidity in non-ambient hypoxic conditions. The objective of the study was to determine the synergistic effect of spices in a decoction; Turmeric ( Curcuma longa ), Pepper ( Piper nigrum ) and Garlic ( Allium sativum ) in combination, on the metabolism of Hep G2 liver cancer cells. The biochemical studies of 2 major enzymes involved in cellular metabolism of cells namely; Pyruvate dehydrogenase (PDH) and Lactate dehydrogenase A (LDHA) showed that the decoction down regulated the activity of LDHA and increased the activity of PDH in cancer cells, thereby shifting the metabolic mechanism towards normal functioning in the cancer cells. The expression studies of major molecules involved in regulating metabolic machinery in cells viz ., tumour suppressor p53 and oncogene MYC mRNAs; and western blot analysis of Hypoxia inducible factor-1-alpha (HIF-1α) and Vascular endothelial growth factor (VEGF) showed that the decoction regulated the expression of these factors helping to revert the metabolism in cancer cells, which could be attributed to the effect of turmeric and also garlic, rich in pantothenic acid, that aids in turning on oxidative phosphorylation in cancer cells. With the above results, it could be concluded that the decoction alters the metabolic mechanism in a cancer cell from lactic acid fermentation to oxidative phosphorylation, like in any other normal cell, thus inhibiting further growth of the cancer.
Bioelectrochemical Modelling of Cytochrome c (1977)

Numerous papers have in recent years been devoted to electrochemical studies of porphyrins and metalloporphyrins. Paradoxically, an investigation of heme c (the prosthetic group of cytochrome c) is conspicuous by its absence. Heme c was first prepared from the naturally occurring protein in a classical piece of work by Theorell (1). Subsequently both heme c and its equatorial ligand (porphyrin c) became accessible by the synthetic route (2,3) outlined in Figure 1. The salient feature of porphyrin c is the bis-cysteinated substitution on the ring, which is unique in cytochrome c among hemoproteins (4). The corresponding substituents in hemoglobin and myoglobin are vinyl groups (5,6). In the present paper, we report some preliminary findings on the electrochemical behavior of porphyrin c and heme c. Experimental Materials. Porphyrin c and heme c were synthesized ad hoc using procedures referred to earlier in this write-up. Yields and elemental analyses are summarized in
Hybrid event recommendation using linked data and user diversity (2013)

An ever increasing number of social services offer thousands of diverse events per day. Users tend to be overwhelmed by the massive amount of information available, especially with limited browsing options perceived in many event web services. To alleviate this information overload, a recommender system becomes a vital component for assisting users selecting relevant events. However, such system faces a number of challenges owed to the the inherent complex nature of an event. In this paper, we propose a novel hybrid approach built on top of Semantic Web. On the one hand, we use a content-based system enriched with Linked Data to overcome the data sparsity, a problem induced by the transiency of events. On the other hand, we incorporate a collaborative filtering to involve the social aspect, an influential feature in decision making. This hybrid system is enhanced by the integration of a user diversity model designed to detect user propensity towards specific topics. We show how the hybridization of CB+CF systems and the integration of interest diversity features are important to improve predictions. Experimental results demonstrate the effectiveness of our approach using precision and recall measures.
The complementary aggregation sites of fibrin investigated through examination of polymers of fibrinogen with fragment E (1998)

Fibrin polymerizes through the interaction of sites exposed by the thrombin-mediated cleavage of fibrinopeptides in the central E region of the protein and complementary sites near the ends of the molecules, open in the D regions of both fibrinogen and fibrin. A preparation of fragment E, containing the central domain and part of the coiled-coil regions of fibrin, was used in mixtures with fibrinogen in this electron microscopy study to investigate the formation of fibrillar structures. At short times, linearly ordered oligomers of fibrinogen were observed with an additional mass of E fragments at the end-to-end junctions. At later times, long flexible polymers made up of 30 or more fibrinogen and fragment E units, with a tendency for lateral aggregation and tangle formation, were seen. These single-stranded assemblies could be readily dissociated in dilute acetic acid into their fibrinogen and fragment E components. However, if the aggregates were treated with factor XIIIa so that all gamma chains became ligated by Nepsilon(gamma-glutamyl)lysine linkages, the polymers could no longer be taken apart. Because the only gamma chains in the preparation are present in the fibrinogen molecules interacting end-to-end, the findings show that the factor XIIIa-induced cross-linking of gamma chains in the clotting of fibrinogen or fibrin must occur between molecules that are longitudinal (or end-to-end) rather than transverse (or half-staggered).
Performance characteristics of protocols with ordered shared locks (2002)

A family of locking-based protocols is analyzed that use a novel mode of locks called ordered sharing. Using a centralized database simulation model, it is demonstrated that these protocols exhibit comparable performance to that of traditional locking-based protocols when data contention is low and exhibit superior performance when data contention is high. It is shown that the performance of these protocols improves as physical resources become more plentiful. This is particularly significant since two-phase locking degrades due to data and not resource contention. Thus, introducing additional resources improves the performance of the proposed protocols while it does not benefit two-phase locking significantly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Softsensorsysteme – Mathematik als Bindeglied zum Prozessgeschehen (2010)

Abstract Softsensorsysteme sind Gebilde, die aus der Notwendigkeit und dem Bewusstsein heraus entstanden sind, dass für eine Vielzahl von Leitgrößen insbesondere in der chemischen oder biotechnologischen Prozesstechnik keine geeigneten Sensoren zur Prozessbeobachtung und darauf aufbauenden Automatisierung vorliegen. Softwaresensoren bestehen in der Regel aus einer Anordnung von einem oder mehreren Sensoren bzw. Messgrößen in Kombination mit einem mathematischen Modellierungsansatz, mit dessen Hilfe eine Relation der verfügbaren Messgrößen zu den gewünschten Prozessgrößen aufgebaut wird. Die Prozessgrößen müssen laboranalytisch erfassbar sein. In Abhängigkeit von der vorliegenden Prozessinformation werden als Algorithmus chemometrische, linguistische, kognitive oder aber auch modellgestützte Verfahren eingesetzt. Der Beitrag gibt einen Überblick über den Aufbau, das Ineinandergreifen der Bestandteile und die Einsatzmöglichkeiten im Prozess.
Recent Developments in the Synthesis of Hair Dyes (1968)

Current trends and research in the synthesis of ‘direct’ dyes and the in‐fibre synthesis of colouring matters for human hair are discussed.
The Influence of Chemical Additives on the Heat Resistance of Salmonella typhimurium in Liquid Whole Egg (1964)

SUMMARY The heat resistance of Salmonella typhimurium in liquid whole egg at pH 5.5 and 55°C was reduced significantly by a number of chemical additives. Of these, the most effective were β‐propiolactone, ethylene oxide, and butadiene dioxide. Additional advantages of ethylene oxide and β‐propiolactone were the elimination of S. typhimurium from heavily inoculated whole‐egg slurry during storage at 0°C and a markedly increased lag phase of growth of the test organism in egg incubated at 30°C. Butadiene dioxide, although not tested at 0°C, was most effective in reducing heat resistance at pH 5.5 and 55° C, and also greatly increased the lag phase of the test organism at 30° C. Unfortunately, this latter compound is carcinogenic to mice. Acetic or lactic acid, used to lower the pH of liquid whole eggs, decreased the heat resistance of S. typhimurium more effectively than did hydrochloric acid, especially at pH 5.5 arid 6.0. Formic and propionic acids also were more effective than HCl when all were tested at pH 5.5. Differences in degree of dissociation between hydrochloric and the organic acids are thought to account, in large measure, for these observations.
Future Utility Analysis Research: Continue, but Expand the Cognitive and Strategic Focus (1995)

[Excerpt] Does utility analysis research have a future? I believe the answer depends on how we contemplate the nature of such research. The distinction between two potential paths has never been more apparent. On the one hand, as researchers, industrial psychologists and others have accumulated decades of utility analysis applications and proposals for new utility approaches and estimation methods. Numerous utility applications exist, especially in selection. Spirited debates have occurred in the scholarly journals on such topics as the value of capital budgeting (Hunter, Schmidt & Coggin, 1988), the appropriate underlying conceptual utility model for scaling performance differences into dollars (Raju, Burke & Normand, 1990), and the appropriate measure of dollar-valued performance variability (SDy) (see Boudreau, 1991 for a review). One would think that after such a long and public history, we would have a set of accepted principles that might guide utility analysis applications, measurement and theory. Unfortunately, we do not. The title of this symposium testifies to the ongoing consternation faced by the scientific community about utility analysis.
Graphene-lead zirconate titanate optothermal field effect transistors (2012)

We have developed a pyroelectric field effect transistor (FET) based on a graphene-lead zirconate titanate (PZT) system. Under the incidence of a laser beam, the drain current can be increased or decreased depending on the direction of the polarization of the PZT substrate. The drain current sensitivity of the optothermal FET can reach up to 360 nA/mW at a drain field of 6.7 kV/m more than 5 orders of magnitude higher than that of the photogating transistors based on carbon nanotube on SiO2/Si substrate. Graphene is an excellent component for pyroelectric FET due to its high optical transparency and conductance.
High Temperature CaO/Y<sub>2</sub>O<sub>3</sub> Carbon Dioxide Absorbent with Enhanced Stability for Sorption-Enhanced Reforming Applications (2011)

To improve the stability of high temperature CO2 absorbent for sorption enhanced reforming applications yttria supported CaO were synthesized using two methods: calcination of mixed salt precursors and wet impregnation of yttria support. According to XRD data, CaO does not interact with the yttria matrix. However, introduction of CaO drastically changes the morphology of primary yttria particles. Increase in CaO concentration results in gradual plugging of the smaller pores and sintering of yttria support. The CO2 absorption uptake in recarbonation-decomposition cycles increases with increase in CaO content and reach 9.6 wt % at CaO content of 19.9 wt %. CaO recarbonation extent varies from 49 to 77%. CaO/Y2O3 absorbents are extremely stable under overheating and maintain their capacity in long series of decomposition-recarbonation cycles even after calcination at 1350 °C. The novel material resists moisture and retains its strength during storage in the air. According to tests, CaO/Y2O3 can be considered as a promising CO2 absorbent for fixed bed sorption enhanced hydrocarbons reforming.
A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. (1993)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Using Write Protected Data Structures To Improve (1991)

This paper describes a database management system (DBMS) modified to use hardware write protection to guard critical DBMS data structures against software errors. Guarding (write- protecting) DBMS data improves software reliability by providing quick detection of corrupted pointers and array bound overruns. Guarding will be especially helpful in an extensible DBMS since it limits the power of extension code to corrupt unrelated parts of the system. Read-write data structures can be guarded as long as correct software is able to temporarily unprotect the data structures during updates. The paper discusses the effects of three different update models on performance, software complexity, and error protection. Measurement of a DBMS which uses guarding to protect its buffer pool show two to eleven percent performance degradation in a debit/credit benchmark.
Semantic modeling of analytic-based relationships with Direct Qualification (2015)

Successfully modeling state and analytics-based semantic relationships of documents enhances thoroughness of representation, contextualization of importance and relevancy, posterity of provenance, and a delineation of priority for a document. These attributes are the core elements that form the machine-based knowledge representation for documents. However, modeling document relationships that can change over time can be inelegant, limited, complex or overly burdensome for semantic technologies. In this paper, we present Direct Qualification (DQ), an approach for modeling any semantically referenced document, concept, or named graph with results from associated applied analytics. The proposed approach supplements the traditional subject-object relationships by providing a third leg to the relationship; the qualification of how and why the relationship exists. To illustrate, we show a prototype of an event-based system with a realistic use case for applying DQ to relevancy analytics of PageRank and Hyperlink-Induced Topic Search (HITS).
Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels, Oman, 2013 (2014)

A countrywide survey in Oman revealed Middle Eastrespiratory syndrome coronavirus (MERS-CoV) nucleicacid in five of 76 dromedary camels. Camel-derivedMERS-CoV sequences (3,754 nucleotides assembled from partial sequences of the open reading frame (ORF)1a, spike, and ORF4b genes) from Oman and Qatar were slightly different from each other, but closely related to human MERS-CoV sequences from the same geographical areas, suggesting local zoonotic transmission. High viral loads in nasal and conjunctival swabs suggest possible transmission by the respiratory route.
Grading of tumors and tumorlike lesions of bone: evaluation by FDG PET. (2000)

FDG PET provides a promising tool for estimating the biologic activity of skeletal lesions, implicating consequences for the choice of surgical strategy.
A Molecular Beacon-Based Duplex Real-Time Polymerase Chain Reaction Assay for Simultaneous Detection of <i>Escherichia coli</i> O157:H7 and <i>Listeria monocytogenes</i> in Milk and Milk Products (2009)

In this study, a real-time polymerase chain reaction assay based on two specific molecular beacons tagged with different reporter dyes was designed and developed for Escherichia coli O157:H7 and Listeria monocytogenes in such a way that each pathogen could be detected simultaneously in a single tube and differentiated. The duplex assay was developed by targeting the rfb gene of E. coli O157:H7 and the hly gene of L. monocytogenes using the homemade master reaction mix. The detection limit of the assay in reconstituted nonfat dried milk (11%) spiked with the two targeted pathogens at different levels was 1 and 3 log colony forming units/mL of each with and without enrichment (6 h) of the sample. The assay was quantifiable for both pathogens over 5 logs with respective regression coefficient 0.9852 (E. coli O157:H7) and 0.9812 (L. monocytogenes). The application of the developed assay on 60 market samples, including 20 samples of two popular Indian indigenous products (10 each of Kulfi and Paneer), revealed three samples involving one each of raw milk, kulfi, and paneer found to be positive for E. coli O157:H7, while one sample of raw milk was positive for L. monocytogenes. The performance of the assay was validated using commercially available individual detection kits for both pathogens, which further authenticated the results by detecting the same samples positive. These assays were set up rigorously in a closed system, therefore enabling rapid, highly specific, and sensitive detection of E. coli O157:H7 and L. monocytogenes in dairy food samples.