gebhart/patrepeval huggingface dataset:
Identification of the receptor for atrial natriuretic factor on cultured vascular cells. (1985)

Binding experiments with 125I-atrial natriuretic factor (ANF) followed by covalent attachment with disuccimidyl suberate show that the peptide binds predominantly to a protein of apparent molecular mass of 66,000 daltons on the cell surface of cultured bovine aortic smooth muscle cells. A minor protein species of 180,000 Mr is also visualized after cross-linking. Endothelial cells, however, whose ANF binding parameters differ substantially from smooth muscle cells, also appear to have qualitatively identical 125I-ANF binding proteins. The identity of these putative proteins, as the ANF receptor, is confirmed by findings that covalent attachment of 125I-ANF is saturable, concentration-dependent, and competed by nanomolar concentrations of unlabeled ANF. Furthermore, other peptide hormones such as angiotensin II, glucagon, or insulin are ineffective in competing for 125I-ANF binding and cross-linking to the receptor.
The East London Study of Maternal Chronic Periodontal Disease and Preterm Low Birth Weight Infants: Study Design and Prevalence Data (1998)

The influence of subject-based and environmental factors on the balance between the subgingival microbial challenge and the host response in periodontal diseases illustrates the intimate link between oral and systemic health. From this stems the hypothesis that the persistent Gram-negative challenge and associated inflammatory sequelae in periodontal disease may have consequences extending beyond the periodontal tissues themselves. This paper addresses the design of a case-control study to examine the relationship between preterm low birth weight (PLBW) and maternal periodontal disease. We present preliminary data on the prevalence of these 2 conditions in a group of mothers at the Royal Hospitals Trust, London, U.K. Cases are defined as mothers delivering an infant weighing less than 2,500g before 37 weeks gestation and controls as mothers delivering an infant of more than 2,500g after 38 weeks. We estimated that a study involving 800 mothers (1:3 case:control) should have sufficient power to detect an association with a minimum odds ration of 3 at the 5% significance level. Demographic details of 177 subjects demonstrated that they were representative of the local population, and the prevalence of PLBW was within the expected range. However, the extent and severity of periodontal disease were higher than predicted and may have reflected elevations in gingival inflammation associated with pregnancy. The final outcome of the study should help determine the need for further interventionist studies to demonstrate a causal relationship between periodontal disease and PLBW, as well as provide information on the prevalence of periodontal diseases in this study population.
Chronic Ethanol Ingestion During Puberty Alters the Transient Increase in Testicular 5α‐Reductase in the Swiss‐Webster Mouse (1989)

Previous experiments with inbred mice showed that chronic ethanol treatment delays male pubertal development. An initial event in sexual maturation in the rat is a transient increase in 5 alpha-reductase. The present study was conducted to determine whether similar ethanol effects occur in outbred mice (Swiss-Webster), to determine the ontological profile of testicular 5 alpha-reductase in the mouse, and to evaluate the effect of ethanol treatment on this enzyme. After 29 days of treatment with a liquid diet (beginning at age 20 days), reductions in the ethanol-treated mice as compared with the controls were noted in testicular weight (55.0 +/- 2.0 vs. 63.0 +/- 2.4 mg; P less than 0.01), epididymal sperm content (6.8 X 10(5) vs. 14.4 X 10(5); P less than 0.05), and sperm motility (45% vs. 57%; P less than 0.05). After 43 days, differences no longer existed. In chow-fed mice, a substantial rise in 5 alpha-reductase (1 unit = 1 pmole DHT formed/45 min/mg testis) began at age 24 days. Activity peaked at approximately 65 units at 25 to 30 days and gradually declined to 6.4 +/- 0.8 units at 63 days. After 29 days treatment, 5 alpha-reductase of the pair-fed control group was 26.8 +/- 4.9 units, which decreased to a baseline value of 7.0 +/- 2.1 units after 43 days treatment. In contrast, 5 alpha-reductase of the ethanol-treated group remained at baseline levels after 29 days (7.7 +/- 2.3 units) and 43 days of treatment (7.6 +/- 2.3 units).(ABSTRACT TRUNCATED AT 250 WORDS)
Photosynthesis in <i>Encelia farinosa</i> Gray in Response to Decreasing Leaf Water Potential (1984)

Photosynthetic responses of intact leaves of the desert shrub Encelia farinosa were measured during a long term drought cycle in order to understand the responses of stomatal and nonstomatal components to water stress. Photosynthetic rate at high irradiance and leaf conductance to water vapor both decreased linearly with declining leaf water potential. The intercellular CO(2) concentration (c(i)) remained fairly constant as a function of leaf water potential in plants subjected to a slow drought cycle of 25 days, but decreased in plants exposed to a 12-day drought cycle. With increasing water stress, the slope of the dependence of photosynthesis on c(i) (carboxylation efficiency) decreased, the maximum photosynthetic rates at high c(i) became saturated at lower values, and water use efficiency increased. Both the carboxylation efficiency and photosynthetic rates were positively correlated with leaf nitrogen content. Associated with lower leaf conductances, the calculated stomatal limitation to photosynthesis increased with water stress. However, because of simultaneous changes in the dependence of photosynthesis on c(i) with water stress, increased leaf conductance alone in water-stressed leaves would not result in an increase in photosynthetic rates to prestressed levels. Both active osmotic adjustment and changes in specific leaf mass occurred during the drought cycle. In response to increased water stress, leaf specific mass increased. However, the increases in specific leaf mass were associated with the production of a reflective pubescence and there were no changes in specific mass of the photosynthetic tissues. The significance of these responses for carbon gain and water loss under arid conditions are discussed.
Problem size limitations for VLSI-based systolic arrays (2003)

VLSI-based systolic arrays have been promoted for almost a decade as efficient structures for many computationally-bound algorithms, such as the large class of matrix manipulation procedures. While they are very powerful conceptually, they suffer an inherent problem of requiring an enormous I/O bandwidth to sufficiently feed and drain the computational array. Satisfying this bandwidth, however, is difficult when the systolic structure is packaged in a pin-limited current technology carrier. Results of a study of the severity of this problem are presented, and data on the maximum size and throughput performance of such an array are provided. The pin limitation problem is solved by multiplexing operands onto and off of the chip, and the performance degrading effect of such multiplexing is obvious.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mechanical properties of dimer fatty acid-based polyamides biocomposites (2011)

Nowadays, replacing petroleum-based materials with renewable resources is a major concern in terms of both economical and environmental points of view. In good agreement with this emergent concept of sustainable development, this work deals with the study of innovative green polyamides (DAPA) based on rapeseed oil-dimer fatty acid reinforced with cellulose fibres (CF). Mechanical properties of DAPA and its biocomposites were examined. Tensile tests were used to follow the effect of strain rate, temperature and filler content on the Young modulus and the yield stress. Tensile tests revealed that the Young modulus and the yield stress highly increased with increasing CF concentration. Halpin-Tsai and Eyring's micro-mechanical models were found to successfully predict the Young modulus and the yield stress respectively, of DAPA and DAPA/Cellulose biocomposites. These results clearly highlighted the attractive properties of DAPA-based biocomposites and demonstrated that these materials are good alternatives to conventional composites. © 2011 Nova Science Publishers, Inc.
Tibiofemoral Joint Positioning for the Valgus Stress Test (2010)

When performing the manual valgus stress test, the clinician should fully extend the tibiofemoral joint or flex it to 5 degrees to assess all resisting medial tibiofemoral joint structures and again at 15 degrees to 20 degrees of joint flexion to further assess the MCL.
The Total Synthesis of Lysergic Acid (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Total Synthesis of Lysergic AcidEdmund C. Kornfeld, E. J. Fornefeld, G. Bruce Kline, Marjorie J. Mann, Dwight E. Morrison, Reuben G. Jones, and R. B. WoodwardCite this: J. Am. Chem. Soc. 1956, 78, 13, 3087–3114Publication Date (Print):July 1, 1956Publication History Published online1 May 2002Published inissue 1 July 1956https://pubs.acs.org/doi/10.1021/ja01594a039https://doi.org/10.1021/ja01594a039research-articleACS PublicationsRequest reuse permissionsArticle Views6724Altmetric-Citations181LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bifidobacterium lactis Enolase, surface localization and mechanism of interaction with human Plasminogen (2008)

The glycolytic enzyme enolase has been identified as putative plasminogen (Plg) binding protein in B. lactis BI07. Since enolase represents one of the best characterized Plg receptors in prokaryotes and eukaryotes, here we characterized this B. lactis housekeeping enzyme with respect to surface localization and Plg binding activity. The display of enolase on B. lactis BI07 cell surface was proved by immunoelectron microscopy. In order to individuated the putative Plg binding sites of B. lactis enolase, an high quality homology model was generated. The B. lactis enolase possesses structural homologue of the internal Plg binding site BS2 of pneumococcal enolase, as well as a C-terminal lysine, which constitute the Plg binding site BS1. In order to characterize the mechanism of Plg binding of B. lactis enolase, the wild type protein, as well as the protein mutated in the BS2, BS1, and BS2/BS1 homologues, were purified and their Plg binding activity evaluated. According to our preliminary data, the homologue of BS2 represents an essential Plg binding site of B. lactis BI07 enolase whereas the homologue of BS1 is only marginally involved.
Self-mixing sensor for real-time measurement of harmonic and arbitrary displacements (2012)

A real-time self-mixing laser displacement sensor is presented that uses a fast consecutive-samples based unwrapping algorithm. The processing is achieved at a rate of 125KHz by an integrated micro-converter (ADuC7020) embedded on the SM sensor. Arbitrary and harmonic displacements have been measured in real-time with λ /10 precision as compared with the reference built-in capacitive feedback sensor of the target, where λ is the laser wavelength. The algorithm does not require any parameter estimation or huge memory and corrects possible false fringe detections. This results in a compact, integrated, precise and self-aligned laser sensor that costs less than 40 $.
Sensitivity of metal detectors to spheroidal targets (1995)

The sensitivity of magnetic metal detectors to prolate or oblate spheroidal targets depends both on the semiaxis ratio and on the orientation of the spheroid polar axis relative to the local magnetic field. A spherical target produces null response only if the generator and detector coil magnetic fields are orthogonal, but the spheroid possesses a null direction for a large range of magnetic field orientations. A spheroid can therefore be made undetectable by rotating it into a particular orientation. The existence of such blind-position angles is investigated theoretically in detail and families of curves are given to illustrate them in a particular case.
Adaptive control of a class of multilinearly parameterized systems by using noncertainty equivalence control (2012)

We propose in this work a new adaptive controller for a class of non-linearly parameterized systems with multi-linear parametrization dependent on the state containing an arbitrary number l of parameters. The proposed controller is non-certainty equivalence based and only the original parameters are adapted. Moreover, since the parameterization depends on the state, a trivial solution by over parameterization is not possible. The main idea of the paper is to combine two parameterizations, one to convexify and another to concavify the nonlinear function of the unknown parameters, because this permits the use of gradient search based convergence in the entire state-space. This leads however to discontinuous Lyapunov functions, and the use of a non-certainty equivalence based control eliminates any possibility of discontinuity, allowing then a standard Lyapunov function to be used. The stability proof relies on the concavity proof of some special functions, that requires in turn the proof of the positive semi-definiteness of an l-dimensional matrix, that is a challenge by itself.
Adaptive signal discrimination as applied to coal interface detection (2003)

A description is given of two coal-rock interface detector (CID) methods associated with vibrations generated by mining machines and how adaptive signal discrimination (ASD) technology is being used to process these signals. In these CID methods, strata (roof, coal seam, floor) or mining machine vibrations are monitored for the complex signals generated, which vary according to the type of mining machine being used. These signals are then analyzed using sophisticated state-of-the-art ASD technology. It is this advanced signal analysis that distinguishes this approach from those of prior research. The ASD system is initially trained using a database of features extracted from known signals measured under conditions of interest. Subsequently, it uses this database to determine if unknown signals belong to a given condition. Assuming that the ASD system classifies these signals correctly, such a system could have the potential for controlling a mining machine so that it always remains in the coal system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Determination of Relative Permeabilities and Capillary Pressures by an Automatic Adjustment Method. (1980)

ABSTRACT Drainage or imbibition experiments in laboratory are often interpreted by trial and error: the flow equations are solved for different values of petrophysical parameters and the best fit determined by successively adjusting calculated productions with measured ones. These methods can be slow and time consuming. In this paper we propose an automatic adjustment method based on optimal control theory. The unsteady one dimensional biphasic flow differential equations have been rewritten so as to exhibit three linearly independent terms which are functions of relative permeabilities and capillary pressure. These three functions are determined by a least square technique following discretization of the equations by a mixed finite elements method. Two types of experiments are needed to carry out the interpretation, one with a fast flow rate, the other with a displacement velocity representative of reservoir conditions. Running the automatic adjustment scheme on the results of the two experiments mentioned above yields directly the relative permeability curves and the capillary term function. The capillary curve is deduced from the capillary term function. Use of mixed finite elements significantly contributes to accuracy and stability in the solution of the equations. Furthermore, the method remains valid in the two limiting cases of hyperbolic (imbibition alone) and parabolic equations (Buckley-Leverett approximation). We illustrate the method for oil displacements by water and gas and for imbibition. Very satisfactory results are obtained, A comparison is also made with results given by trial and error adjustment.
Management of Chronic Otitis Media for Cochlear Implantation and Other Implantable Devices. (2016)

Whitney U-test) compared with the previous generation implant.
Cure kinetics modeling and process optimization of the vialux 81 epoxy photodielectric dry film (PDDF) material for microvia applications (2002)

The cure kinetics of a photodielectric dry film (PDDF) material called ViaLux 81 has been studied, with the aim of understanding and optimizing its curing schedule for the fabrication of sequentially built-up (SBU) high-density-interconnect printed wiring boards (HDI-PWB). Initial dynamic differential scanning calorimetry (DSC) scans on the material revealed a two-stage curing mechanism due to the long lifetime of the photoinitiator catalyst, which could not be separated at lower heating rates. On the other hand, the heat flow exotherm from isothermal DSC experiments showed a rapid reaction rate at the beginning with only a single peak. Therefore, to capture the complexity of the process, the faster multiple heating rate DSC experiments are used to predict the degree-of-cure (DOC) evolution. Two approaches have been developed based on the dynamic DSC data: (1) a “model-free” approach, which only requires information about the cure-dependence of the activation energy; and (2) a practical scheme to deconvolute the two curing peaks. Excellent agreement is observed for the heating rate experiments, but the methods are inadequate for predicting the DOC evolution under isothermal conditions. Therefore, a modified autocatalytic model with temperature-dependent kinetic parameters has been developed based on the isothermal DSC data. This model predicts the DOC evolution for isothermal curing profiles very well. However, some discrepancy is evident in predicting the DOC evolution for heating rate experiments, due to the underestimation of the activation energy. With appropriate corrections, excellent predictive capability is illustrated for complex cure schedules with combined heating rate and isothermal segments. In addition, a cure process optimization strategy has been suggested, and the fabrication of fine features and microvias is demonstrated. © 2002 John Wiley & Sons, Inc. J Appl Polym Sci 84: 691–700, 2002; DOI 10.1002/app.2345
Compiler-directed shared-memory communication for iterative parallel applications (1996)

Many scientific applications are iterative and specify repetitive communication patterns. This paper shows how a parallel-language compiler and custom cache-coherence protocols in a distributed shared memory system together can implement shared-memory communication efficiently for applications with unpredictable but repetitive communication patterns. The compiler uses data-flow analysis to identify program points where repetitive communication occurs. At runtime, the custom protocol builds communication schedules in one iteration and uses it to pre-send data in following iterations. This paper contains measurements on three iterative applications (including adaptive programs with unstructured data accesses) to show that custom protocols increase the number of shared-data requests satisfied locally, thus reducing the amount of time spent waiting for remote data.
Eight Cases of Severe Acute Respiratory Syndrome Presenting as Round Pneumonia (2004)

SARS may present as round pneumonia on chest radiographs initially or during the treatment course. It may remain unchanged for up to 9 days before evolution to ill-defined air-space opacities. Radiologists and physicians should consider the possibility of "SARS pneumonia" when spherical air-space opacities are noted on chest radiographs of febrile patients.
Reaction of the Dioxane-Sulfotrioxide Reagent with Aniline. Classification of the Sulfamic Acids (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of the Dioxane-Sulfotrioxide Reagent with Aniline. Classification of the Sulfamic AcidsCharles D. Hurd and Norman KharaschCite this: J. Am. Chem. Soc. 1947, 69, 9, 2113–2115Publication Date (Print):September 1, 1947Publication History Published online1 May 2002Published inissue 1 September 1947https://pubs.acs.org/doi/10.1021/ja01201a013https://doi.org/10.1021/ja01201a013research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Earmold Options for Wideband Hearing Aids (1981)

A summary of recent developments in earmold constructions for wideband hearing aids is presented. Earmold modification techniques, special earmolds, and temporary earmolds are discussed. The appendix contains the results from transmission line theory as applied to earmold acoustics and some sources for useful earmold supplies.
A study of the different interfaces in Fe/V superlattices (2001)

Interfaces in Fe(xML)/V(yML) multilayers have been examined. Two pairs of samples each with definite x and y were prepared using the same deposition process and the same elemental variations with the 57Fe probe layers interfoliated between completed V and Fe (natural abundance) layers. The only difference was the deposition ordering. The superlattice structures were analyzed by X-ray diffraction and 57Fe Conversion Electron Mössbauer Spectroscopy at room temperature and at 10 K. The 57Fe magnetic hyperfine field distribution for the pairs is found to be significantly different, irrespectively of the values of x, and y and can be interpreted as due to the Fe layer being smoother than the V one. The magnetic moments derived for the interface layer as well as for the subsequent atomic layer are significantly lower than the calculated values.