gebhart/patrepeval huggingface dataset:
Comparative Biopharmaceutical Performance of Imipramine Formulations in Man (1980)

The systemic availability of an investigational liquid formulation of imipramine was compared to that of a commercially available tablet (Tofranil) whose therapeutic efficacy has been established by usage. The experiment was conducted under controlled conditions and a balanced 2-by-2 crossover design was used to dissociate the significance of formulation effects from subject, group, and experimental period sources of variation. Pharmacokinetic interpretation and statistical analysis of plasma concentrations as a function of time and of systemic availability indicators reveal a nearly identical biopharmaceutical behavior for the two preparations. Significant differences (P less than 0.05) were found in the cumulative area under the plasma concentration--time curve (AUC) up to 4 hours after administration and the availability lag time, but not in the maximum plasma concentration, the time at which this concentration is reached, the first-order availability rate constant, and the AUC to infinity. These results collectively indicate a very similar biopharmaceutical performance, where the differences in the early AUC values are partly attributable to a longer availability lag time for the tablet formulation.
ChemInform Abstract: Dioxygen Activation by Organometallics of Early Transition Metals (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: CLUSTERING OF METAL ATOMS IN ORGANIC MEDIA. II. EFFECT OF SUPPORT ON NICKEL CATALYSTS PREPARED BY SOLVATED METAL ATOM DISPERSION (SMAD) (1982)

Abstract Toluol (I) wird mit Nickel in Komplexe (II) übergeführt, die thermisch über (III) zu den Nickel‐ Träger‐Katalysatoren (IV) umgesetzt werden.
A high-frequency AC distributed power system with dual PWM buses (2003)

A high-frequency (HF) AC distributed power system (DPS) with dual PWM buses is presented. An experimental prototype with a total of 210 W output power for three independent outputs, i.e. 3.3 V@30 A, 5.0 V@10 A, and 12 V@5.1 A, was built to verify the concept presented in this paper. The experimental results demonstrate that the proposed system works well and the around 80% efficiency, which is 3% higher than that from single bus DPS under same operation conditions, can be obtained.
Multiphase Direct AC Wireless Power Transfer System: Comparative Proposals Using Frequency and Amplitude Modulations (2021)

Using multiload wireless power transfer (WPT) systems to supply power to multiple receivers with a single transmitter is an interesting topic. However, previous studies are all based on a dc-dc WPT system. If the loads demand ac power, additional dc-ac inverters need to be implemented, which increases the system complexity and cost. This article addresses two direct ac WPT systems that can regulate the ac power of multiple phases or loads independently, using frequency modulation and amplitude modulation (AM), respectively. The proposed WPT systems can directly control the ac power of multiple loads through the transmitter side, without any power converter at the receiver side. A typical application of the proposed system is for powering a three-phase load in a rotational object, e.g., three-phase motors in articulated robots or in-wheel motors. To demonstrate the feasibility of the proposed WPT systems, simulation and experiment studies of a wireless three-phase power transfer are presented. The results suggest that AM is a more advantageous solution to a direct ac WPT system. A power-loss breakdown analysis is presented to suggest future steps of efficiency improvement.
ON THE REACTION OF BENZOHYDROXAMIC ACIDS WITH LAWESSON'S REAGENT (1998)

Abstract Reaction of Lawesson's Reagent (LR) with two N-alkyl benzohydroxamic acids is presented. In addition to the desired thiohydroxamic acids 2, the reduction process provides amides 3 and thioamides 4. An unexpectedly pronounced solvent effect on the course of the reaction was observed. The best yields (40–50%) of 2a were obtained in THF, and in this solvent amide 3a was not formed. In HMPA solution the amide 3a and the thioamide 4a were the only products, and 2a was not formed at all. Key Words: Hydroxamic acidsLawesson's Reagentthiohydroxamic acidsthioamides
Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31 (2013)

We developed a gene expression-based predictive model for degree of benefit from trastuzumab and demonstrated that HER2-negative tumors belong to the moderate benefit group, thus providing justification for testing trastuzumab in HER2-negative patients (NSABP B-47).
Discussion sur une somme à attribuer à la dame Mabilly, lors de la séance du 17 septembre 1791 (1888)

Camus Armand Gaston, Hébrard de Fau Pierre, Prieur de la Marne Pierre Louis, Curt Louis de. Discussion sur une somme à attribuer à la dame Mabilly, lors de la séance du 17 septembre 1791. In: Tome XXXI - Du 17 au 30 septembre 1791. p. 3.
Towards wavelength selective shutters for device application for filters and smart windows (1994)

Ideal wavelength selective shutters (or filters) need to have sharp, high intensity, easily switchable absorption bands in the desired region of the electromagnetic spectrum. If such devices are to be used for smart window applications, then selective control of all the visible and near infrared regions of the electromagnetic spectrum would be desirable. No single material as yet offers such selectivity. The choice and properties of such material would also depend on ease of use and friendliness to the environment. Metal phthalocyanine materials are potentially useful electrochromics, the neutral molecules are non-toxic, brightly coloured (have narrow absorption bands with high extinction coefficients) and are also stable to heat and light. Metal bisphthalocyanine electrochromics (where the metal is based on the rare earth elements, Zr, Sn or Pb) have some promise in this area and will be discussed. A number of metal monophthalocyanines compounds where the metals are transition elements (such as V, Cr, Mn, Fe and Co) and non-transition elements (such as Al, Si and Sn) that offer some useful spectral properties will also be discussed. The possibilities of using cocktails of these compounds to give desirable performance, their projected advantages and disadvantages will also be debated. A bright future is envisaged for these materials. >
Editorial: The Future of Psychology as an Open Access Journal Welcoming Applied Neuroscience (2014)

In my role as editor in chief I want to take the chance to say a few words on behalf of the entire SCIRP team. The current times and trends within the world of academia are exciting. During the last few years various publishers followed the Open Access model, which I myself have found a great step forward since day one of its existence. Science is largely paid through money from the public and thus the public should have free access to its outcome. That is the fairest approach to it. Also, for a scientist it is much easier to distribute own work by simply sending a link that allows the recipient to freely download the respective article. In other words, Open Access is the future, which fortunately became the present already.
Health and Safety Awareness for Working Teens (2005)

Adolescents suffer higher rates of work-related injuries than do adults. A school-based education program can provide young workers with information and skills that will reduce their risk. A successful program in Washington State, Health and Safety Awareness for Working Teens, adapted existing curricula to meet state needs. The curricula featured interactive exercises designed to engage students with a variety of learning styles. In-person trainings at teacher conferences proved the most effective way to disseminate the curricula across the state. Evaluations showed that student knowledge increased after exposure to the curricula and that teachers found the curricula to be useful and easy to use.
An integrated system for people fall-detection with data fusion capabilities based on 3D ToF camera and wireless accelerometer (2010)

This paper presents a multi-sensor system for the detection of people falls in the home environment. Two kinds of devices are used: a MEMS wearable wireless accelerometer with onboard fall detection algorithms and a 3D Time-of-Flight camera. An embedded computing system receives the possible fall alarm data from the two sub-sensory systems and their associated level of confidence. The computing module hosts a data fusion software to operate the validation and correlation among the two subsystems delivered data in order to rise overall system efficiency performance with respect to each single sensor sub-system.
Estrogen Receptor Inducibility of the Human Na<sup>+</sup>/H<sup>+</sup>Exchanger Regulatory Factor/Ezrin-Radixin-Moesin Binding Protein 50 (NHE-RF/EBP50) Gene Involving Multiple Half-Estrogen Response Elements (2002)

The Na+/H+ exchanger regulatory factor (NHE-RF; also known as ezrin-radixin-moesin binding protein 50) is a primary response gene under estrogen receptor (ER) control that may provide a link between estrogen action and the regulation of cytoskeletal and cell-signaling pathways. These studies were undertaken to define the human NHE-RF genomic regions and regulatory sequences mediating its robust estrogen responsiveness. Screening of a human genomic library yielded NHE-RF clones comprising the full gene, including the 5'-regulatory region and first exon, which were found to contain a large number (13) of consensus half-estrogen response elements (EREs), but to lack palindromic full EREs. Transfection-transactivation assays with wild-type and mutant ERs and reporter gene constructs linked to progressive deletions, or containing mutations, of the 5'-flanking region including a portion of exon I, and electrophoretic mobility and competitive gel shift assays were performed. These demonstrated direct ER interaction with the multiple half-ERE sites and the importance of the one proximal half-ERE and the multiple upstream half-EREs for eliciting the robust transcription activation of the NHE-RF gene by the estrogen-ER complex. Our findings highlight a paradigm for gene regulation via numerous half-ERE sites that expands the range of modes by which DNA recognition sites mediate the actions of this nuclear receptor.
ChemInform Abstract: Synthesis of Carbobicyclic Compounds via Palladium‐Catalyzed Cyclization/Hydrosilylation: Evidence for Reversible Silylpalladation. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analysis of Dynamic Grain Growth Behavior during Superplastic Deformation Using a Grain Boundary Diffusion Mechanism (1999)

The enhanced grain growth behavior during superplastic deformation is analyzed on the basis of grain boundary diffusion mechanism. On the grain boundary where both static and dynamic potential differences exist, matter diffusing along the boundary is assumed to deposit on the grain surface locating opposite to the direction of grain boundary migration and to contribute to the dynamic grain growth. The amount of the diffusive matter is calculated for the deformation of a spherical grain and is converted to the increment in the mean boundary migration velocity. The obtained relationship between the strain rate and the dynamic grain growth rate is independent of the mechanism of superplastic deformation. The dynamic grain growth behavior predicted from the present model is consistent with the experimental results of ZrO2-dispersed Al2O3.
pKa-critical Interpretations of Solubility–pH Profiles: PG 300995 and NSC-639829 Case Studies (2015)

Two weak bases, PG-300995 (anti-HIV agent) and NSC-639829 (anti-tumor agent), whose log S – pH profiles had been previously published, but whose pKa values had not been reported, were analyzed using a method which can determine pKa values from log S – pH data. This “SpH-pKa” technique, although often practiced, can result in inaccurate pKa values, for a variety of reasons. The operational SpH-pKa values were compared to those predicted by MarvinSketch (ChemAxon), ADMET Predictor (Simulation Plus), and ACD/Percepta (ACD/Labs). The agreement for the sparingly-soluble PG-300995 was reasonably good. However, a substantial difference was found for the practically-insoluble NSC-639829. To probe this further, the pKa of NSC‑639829 was measured by an independent spectrophotometric cosolvent technique. The log S - pH profile of NSC-639829 was then re‑analyzed with the independently-measured pKa. It was found that the equilibrium model which best fit the solubility data is consistent with the presence of a monocationic NSC-639829 dimeric species below pH 4. This illustrates that an independently-determined accurate pKa is critical to mechanistic interpretations of solubility-pH data. Apparently, the Henderson-Hasselbalch equation holds for PG-300995, but not NSC-639829.
<title>Quantitative analysis of functional dynamic images using knowledge-based factor analysis</title> (1992)

ABSTRACTWe have applied the method of knowledge-based factor analysis to a variety of dynamic nuclear medicine functional studies including renal, liver, lung, and brain. A Principal Component Analysis (PCA) is applied in the temporal domain to decompose the image sequence to a limited number of components containing the mostsignificant information. The signature of the Poisson noise is used to eliminate random variations. By applying prior information as constraints to the factor rotation, factor images and their associated time functions are generatedwhich show a direct correspondence to the underlying physiology represented by the conventional kinetic models.These time functions can be analyzed to provide robust estimates of quantitative parameters which are clinicallyuseful. 2. INTRODUCTION Factor analysis has been previously developed for the reduction and trend analysis of psychological data. The basicfactor analytic model is a general method for transforming a large number of variables into a simpler and more useful
<title>Sequential hypothesis testing for dynamic SAR resource allocation</title> (1998)

In this paper we describe a novel method of automatic target detection applied directly to the synthetic aperture radar (SAR) phase history. Our algorithm is based on a sequential likelihood ratio test (Wald test). The time dynamic behavior of the SAR phase history is modeled as a 2D autoregressive process. The sequential test attempts to dynamically ascertain the presence/absence of a target while the SAR phase history data is being collected. A target/no target decision can then be made during the collection aperture. System resources such as collection aperture and image formation processing can be dynamically reallocated depending on scene content. In contrast, image based detection methods wait until the entire aperture is collected, an image formed, then an algorithm is applied. We will show that significant savings in collection aperture can be obtained using this detection structure which may increase system search rates.
Characterization of Human Platelet Vascular Permeability-Enhancing Activity (1972)

Human platelet acid extract obtained from both whole platelets and from isolated subcellular granules was partially purified by DEAE-cellulose chromatography and Sephadex gel filtration. The heat-stable, nondialyzable cationic protein fraction with a mol wt of approximately 30,000 produced a biphasic increase in vascular permeability in rabbit skin and also had antiheparin activity. The acute (15 min) increase in vascular permeability was blocked by prior treatment of the animal with antihistamine and was characterized histologically by edema of perivascular tissues and dilation of capillaries and veinules. The delayed (3 hr) permeability effect was not blocked by antihistamine and was characterized histologically by leukocytic infiltration into the skin. The experiments described suggest that human platelet lysosomal release of cationic proteins may increase vascular permeability by several mechanisms including endogenous histamine release as well as delayed chemotaxis.
Mobility of organic pollutants absorbed on clays monitored by various MAS NMR approaches (2005)

Poster
Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis (2009)

Randomized, controlled trials have demonstrated efficacy for second-generation antipsychotics in the treatment of acute mania in bipolar disorder. Despite depression being considered the hallmark of bipolar disorder, there are no published systematic reviews or meta-analyses to evaluate the efficacy of modern atypical antipsychotics in bipolar depression. We systematically reviewed published or registered randomized, double-blind, placebo-controlled trials (RCTs) of modern antipsychotics in adult bipolar I and/or II depressive patients (DSM-IV criteria). Efficacy outcomes were assessed based on changes in the Montgomery-Asberg Depression Rating Scale (MADRS) during an 8-wk period. Data were combined through meta-analysis using risk ratio as an effect size with a 95% confidence interval (95% CI) and with a level of statistical significance of 5% (p<0.05). We identified five RCTs; four involved antipsychotic monotherapy and one addressed both monotherapy and combination with an antidepressant. The two quetiapine trials analysed the safety and efficacy of two doses: 300 and 600 mg/d. The only olanzapine trial assessed olanzapine monotherapy within a range of 5-20 mg/d and olanzapine-fluoxetine combination within a range of 5-20 mg/d and 6-12 mg/d, respectively. The two aripiprazole placebo-controlled trials assessed doses of 5-30 mg/d. Quetiapine and olanzapine trials (3/5, 60%) demonstrated superiority over placebo (p<0.001). Only 2/5 (40%) (both aripiprazole trials) failed in the primary efficacy measure after the first 6 wk. Some modern antipsychotics (quetiapine and olanzapine) have demonstrated efficacy in bipolar depressive patients from week 1 onwards. Rapid onset of action seems to be a common feature of atypical antipsychotics in bipolar depression.
A new human erythrocyte variant (Ph) containing an abnormal membrane sialoglycoprotein (1980)

1. A new human erythrocyte variant (Ph) is described. The variant contains an unusual sialic acid-rich glycoprotein in addition to the blood-group-MN([unk])- and blood-group-Ss(delta)-active sialoglycoproteins found in normal erythrocytes. 2. The unusual component Ph has an apparent mol.wt. of 32000 on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. The Ph component is not degraded during trypsin treatment of intact erythrocytes. 3. The Ph component was labelled by lacto-peroxidase-mediated radioiodination of intact erythrocytes and was found to be present in amounts approximately equimolar to alpha-sialoglycoprotein in the variant erythrocytes. 4. The Ph component had receptors for the lectins from Maclura aurantiaca (osage orange) and Triticum vulgaris (wheat-germ), but lacked a receptor for the Phaseolus vulgaris (red kidney bean) lectin, suggesting that it carries only O-linked oligosaccharides. 5. The presence of the Ph component in these erythrocytes does not correspond to any of the known blood-group-MNSs-related antigens examined. 6. We suggest that this component may be a hybrid polypeptide containing the N-terminal portion derived from normal delta-sialoglycoprotein, and the C-terminal portion from normal alpha-sialoglycoprotein, in a manner similar to the anti-Lepore haemoglobin.
Prediction of Chlamydia trachomatis Infection: Application of a Scoring Rule to Other Populations (2006)

The chlamydia prediction rule showed a reasonable external validity in two studies. These findings support the use of the rule as a tool for selective chlamydia screening, although only a limited fraction of participants can be excluded when a high sensitivity is required.
Elimination of Spectral Interferences for the Determination of Fe and Se in Biological Samples Using ICP-Ion Trap Mass Spectrometer (2005)

イオントラップ型質量分析計を採用している誘導結合プラズマ三次元四重極質量分析計を用いて，生体試料中のFe及びSeに関するスペクトル干渉を低減し，生体試料中のFe及びSeの測定を行った．三次元四重極質量分析計（3DQMS）のイオンレベルとfiltered noise field（FNF）機能を最適化することにより，78Se＋，80Se＋，82Se＋に対するAr2＋，31P216O＋，32S16O3＋及び12C35Cl2＋のスペクトル干渉は低減できた．40Ar2＋を低減した結果，80Seにおけるダイナミックレンジは100 ppt～100 ppmの7けたで，検出限界は11 pptを達成した．3DQMSのcollision induced dissociation（CID）機能を使用することにより，40Ar16O＋，40Ca16O＋及び79Br1H＋，81Br1H＋のスペクトル干渉を低減した．Fe及びSeの信号強度及び同位体比から求めたCIDの最適条件は0 V，500 msであった．イオンレベル，FNF及びCIDの最適条件の下で，ヒト尿標準物質（NIES CRM 18及びSeronorm 2524）中のSeを定量した結果，誤差範囲内で参照値と一致した．また，ヒト尿標準物質（Seronorm 2524）中のFeの添加回収実験を行った結果，101％ の回収率を得ることができた．本法を用いることで，生体試料中のFe及びSeを天然同位体比の最も大きい56Fe及び80Seを用いて定量することができた．
Marginal Zone Lymphoma and Other Low‐Grade B Cell Lymphoproliferative Disorders of the Skin (2006)

This chapter contains sections titled: Case Vignettes References
Photoconducting Polymers for Photorefractive 3D Display Applications (2010)

Photorefractive composites derived from photoconducting polymers offer the advantage of dynamically recording holograms without the need for processing of any kind. Thus, they are the material of choice for many cutting edge applications, such as updatable 3D displays and imaging through a scattering medium. This article reviews the basic properties of photorefractive polymer systems and the inherent advantages that have attracted much attention. The chemistry and physics relevant for the design of the high-performance guest−host composite are discussed and recent advances emphasized. In particular, a charge transporting polymer with high mobility and history-independent response times is highlighted, as well as polymer systems useful for holographic displays and the material considerations necessary to develop high-speed, large-sensitivity composites.
Monitoring for Ultra-Precision Grinding using Induced Current (2004)

This paper proposes a newly developed monitoring system for grinding ultra-precision small size casting die having asphericl surface. Small size aspheric glass lenses are widely used for IT industry. The lenses are cast in cemented carbide die because of its high melting temperature and the die is usually ground by small size diamond grinding wheels. The wheel can not be changed or dressed in finish grinding, because changing or dressing the wheel brings deterioration of die accuracy, therefore, very light grinding conditions must be adopted, such as less than one micrometer of depth of cut. In such conditions, monitoring of grinding state, such as that of grinding force, is indispensable to achieve high quality and high efficient grinding. However sensing of very low grinding force is quite difficult, because of the system stability and Signal/Noise ratio in the sensing. In the system developed, an induced current was applied to a closed circuit, which was consisted from die, diamond wheel, spindle, air bearing and machine tool, by a ring coil coupling with the circuit and the current was detected by an another ring coil. The current was depended on an impedance of the circuit, and the impedance was influenced by the conditions between die and grinding wheel, Stable or unstable grinding conditions was detected, so that high efficiency ultra-precision grinding was achieved by using the system.