gebhart/patrepeval huggingface dataset:
A Six-Bowl Carceplex That Entraps Seven Guest Molecules (2005)

A six-bowl carceplex that entraps seven guest molecules, 5.(DMSO)7, was synthesized and characterized. The dynamics of the host shell was studied in solution in the absence and presence of water. A multiple-molecule template was found to drive the formation of 5.(DMSO)x.G(7-x) (G = DMA, DMF; x = 5-7). Higher selectivity was found for species containing greater numbers of DMSO molecules.
Modifications of Optical Properties of Blood during Photodynamic Reactions<i>In vitro</i>and<i>In vivo</i> (2011)

This chapter contains sections titled: Introduction Description and Brief History of PDT PDT Mechanisms Blood and PDT Properties of Blood, Blood Cells, and Photosensitizers: Before Photodynamic Reaction Photodynamic Reactions in Blood and Blood Cells, Blood Components, and Cells Types of Photodynamic Reactions in Blood: In vitro versus In vivo Blood Sample In vitro as a Model Studying Photodynamic Reaction Monitoring of Oxygen Consumption and Photobleaching in Blood during PDT In vivo Photodynamic Disinfection of Blood Photodynamic Therapy of Blood Cell Cancer Summary Acknowledgments Glossary References
Integrally closed ideals in two-dimensional regular local rings are multiplier ideals (2003)

Multiplier ideals in commutative rings are certain integrally closed ideals with properties that lend themselves to highly interesting applications. How special are they among integrally closed ideals in general? We show that in a two-dimensional regular local ring with algebraically closed residue field there is in fact no difference between "multiplier" and "integrally closed" (or "complete.") But among multiplier ideals arising from an integer multiplying constant (also known as adjoint ideals), and primary for the maximal ideal, the only simple complete ideals are those of order one.
Restoration of Abdominal Wall Integrity as a Salvage Procedure in Difficult Recurrent Abdominal Wall Hernias Using a Method of Wide Myofascial Release (2001)

The management of primary and recurrent giant incisional hernias remains a complex and frustrating challenge even with multiple alloplastic and autogenous closure options. The purpose of this study was to develop a reconstructive technique of restoring abdominal wall integrity to a subcategory of patients, who have failed initial hernia therapy, by performing superior and lateral myofascial release. Over a 1.5-year period, 10 patients with previously unsuccessful treatment of abdominal wall hernias, using either primary repair or placement of synthetic material, were studied. The patients had either recurrence of the hernia or complications such as infections requiring removal of synthetic material. The hernias were not able to be treated with standard primary closure techniques or synthetic material. The average defect size was 19 x 9 cm. Each patient underwent wide lysis of bowel adhesions releasing the posterior abdominal wall fascia to the posterior axillary line, subcutaneous release of the anterior abdominal wall fascia to a similar level, and complete removal of any synthetic material (if present). The abdominal domain was reestablished by releasing the laterally retracted abdominal wall. The amount of available abdominal wall tissue was increased by wide release of the cephalic abdominal wall fascia overlying the costal margin and the external oblique fascia and muscle laterally. If needed, partial thickness of the internal oblique muscle and its anterior fascia were also released laterally to perform a tension-free primary closure of the defect. All repairs were closed with satisfactory functional and aesthetic results. All alloplastic material was removed. Fascial release was limited so as to close only the hernia defect without tension. No significant release of the rectus sheath and muscle was needed. Good, dynamic muscle function was noted postoperatively. All repairs have remained intact, and no further abdominal wall hernias have been noted on follow-up.
Numerical study of the multiple-scattering series for gas-solid dynamics including single- through triple-collision terms (1994)

The multiple-scattering series for the transition amplitude in gas-surface collisions is examined using elastic atom-surface diffraction as a test bed. Performing numerical calculations for various scattering angles and incident energies, we assess the role of double and triple successive collisions between the projectile and the surface atoms. For rigid lattices, double- and triple-collision terms are found to be significant in the thermal energy regime and even in the higher-energy regime if the surface is highly corrugated. However, at superthermal incident energies (E\ensuremath{\gtrsim}0.2 eV), the single-collision terms give a good approximation to the overall scattering intensities, provided that the ranges of the atom-pair potentials do not overlap; nevertheless, multiple collisions are still important in elastic scattering with large parallel momentum transfers. These results indicate that single-collision approximations should be employed with care for elastic diffraction.
Pathogenic role of anti-endothelial cell antibodies in vasculitis. An idiotypic experimental model (1996)

Idiotypic manipulation of naive mice has previously been used for induction of systemic autoimmune diseases (e.g., antiphospholipid syndrome, systemic lupus erythematosus, and Wegener's granulomatosis). The aim of this study focused on the utilization of this technique to induce the production of anti-endothelial cells Abs (AECA) and autoimmune vasculitis in a murine model. AECA were derived from a Wegener's granulomatosis patient's plasma. IgG was purified by absorption on a proteinase-3 affinity column resulting in the depletion of anti-neutrophil cytoplasmic Ab activity. The absorbed IgG fraction displayed a high titer of AECA as evidenced by a cyto-ELISA against unfixed human umbilical vein endothelial cells. BALB/c mice were actively immunized with the purified AECA. Three months after a boost injection with the human AECA, mice developed endogenous AECA (AB), but not Abs to proteinase-3, cardiolipin, or DNA. Histologic examination of lungs and kidneys revealed both lymphoid cell infiltration surrounding arterioles and venules; as well as deposition of Igs at the outer part of blood vessel walls. This experimental animal model of vasculitis, a product of our method of idiotypic manipulation, provides the first direct proof for the pathogenicity of AECA.
Benzo[g]quinolines. II. Novel synthesis and pharmacological evaluation of cis-1-alkyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolines (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzo[g]quinolines. II. Novel synthesis and pharmacological evaluation of cis-1-alkyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolinesWilliam F. Michne and Noel F. AlbertsonCite this: J. Med. Chem. 1970, 13, 3, 522–525Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 May 1970https://pubs.acs.org/doi/10.1021/jm00297a040https://doi.org/10.1021/jm00297a040research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Global Routing for Force Directed Placement (2006)

This paper presents a global routing model that can be directly integrated into a force directed placement flow. In contrast to previous approaches, this new model takes geometrical routing attributes into special consideration already during the placement phase. Additionally, a novel way of estimating congestion is introduced. Results show that the model leads to a decrease in congestion on global level
Near-Bandgap, Narrow-Spectrum, Low-Loss, Volume-Excited GaAs Laser (77°K) with Time-Uniform Output (1970)

Data are presented showing that it is possible to operate lightly doped GaAs as a laser at energies exceeding 1.500 eV at 77°K (Eg=1.513 eV), to obtain essentially monoenergetic operation well above threshold and to avoid the mode jumping effects common to optically pumped lasers. This has been accomplished by volume exciting the center n region (selective absorption) of a low-loss n+/n/n+ epitaxial wafer under conditions of limited absorption which in turn allows stabilization of the carrier concentration and the photon energy of the recombination radiation.
A single amino acid, outside the AlcR zinc binuclear cluster, is involved in DNA binding and in transcriptional regulation of the <i>alc</i> genes in <i>Aspergillus nidulans</i> (1999)

In Aspergillus nidulans, the transcriptional activator AlcR mediates specific induction of a number of alc genes. The AlcR DNA-binding domain is a zinc binuclear cluster that differs from the other members of the Zn2Cys6 family in several respects. Of these, the most remarkable is its ability to bind in vitro as a monomer to single sites, whereas only repeated sites (direct or inverted) are necessary and functional in vivo. Deletion of the first five amino acids (following the N-terminal methionine) upstream of the AlcR zinc cluster or mutation of a single residue, Arg-6, impairs the AlcR in vitro binding mainly to symmetrical sites. In vivo, the same mutations result in the inability of A. nidulans to grow on ethanol. The alc- phenotype results from a drastic decrease in activation of its own transcription and, in addition, that of the two structural genes, alcA and aldA, required for ethanol oxidation. This defect seems to be correlated to the inability of the Arg-6 AlcR mutant protein to bind to AlcR palindrome targets, which are essential in the three alc promoters. AlcR shows a unique pattern of binding and of transactivation among the Zn2Cys6 family.
The combustion gas turbine (1944)

THERE ARE many conceivable future uses of the gas turbine, because it potentially promises higher efficiency at very high temperatures than most engines and prime movers used today. Future applications range from electric-power generation to power plants for propelling airplanes, trains, and ships.
925-P: Participation in Daily Physical Activity (PA) Improves Glycemic Control in Youth with T1D (2021)

Aim: PA is an important part of diabetes management. ADA recommends that youth with T1D participate daily in ≥60 minutes of moderate to vigorous PA. We prospectively assessed daily PA in youth with T1D and compared demographic and diabetes variables according to frequency of PA ≥60 minutes/day. Methods: Youth (N=125, ages 8-17) with T1D completed 3-day PA records every 3 months for 18 months. Diabetes treatment data and A1c were collected at the same time. For each youth, we calculated the % of days with ≥60 minutes PA and compared those with ≥60 minutes PA on &lt;50% vs. ≥50% of days. Youth with at least 6 days of PA data over 18 months were included. In analyses, baseline age, T1D duration, and pump use were used; mean values over the 18-month period for A1c, insulin dose, and BMI percentile were used. Results: Youth (50% male, 90% white, 74% pump-treated) had a mean±SD age 12.8±2.5 years, T1D duration 6.0±3.2 years, and A1c 8.2±0.9%. Youth had a median of 16 (IQR 12-17) PA record days. The % of days with ≥60 minutes PA ranged from 0 to 100% (median 53% [IQR 35-71%]), with 59% of youth reporting ≥60 minutes PA on ≥50% of days. Youth with ≥60 minutes PA on ≥50% of days were younger (12.4 vs. 13.5 years, p=.02), had shorter T1D duration (5.2 vs. 7.0 years, p=.002), lower daily insulin dose (0.86 vs. 1.00 u/kg, p=.002), and lower A1c (8.1 vs. 8.4%, p=.03) than youth with ≥60 minutes PA on &lt;50% of days. There were no significant differences in sex (51 vs. 47% male, p=.64), race/ethnicity (93 vs. 84% white, p=.11), BMI percentile (69 vs. 70%, p=.85), or pump use (74 vs. 73%, p=.82) between those with ≥60 minutes PA on ≥50% vs. &lt;50% of days. There was a notable temporal difference in youth having ≥60 min PA on ≥50% of days in the summer (75%), fall (51%), winter (58%), and spring (65%), respectively (p=.004). Conclusion: A substantial proportion of youth with T1D do not exercise per recommendations. Given associations of PA with lower A1c, additional efforts to support exercise management in T1D are needed along with support for PA throughout the year. Disclosure R. O. La banca: None. L. K. Volkening: None. H. Desrochers: None. E. Dassau: Consultant; Self; Eli Lilly and Company, Employee; Self; Eli Lilly and Company, Research Support; Self; Dexcom, Inc., Tandem Diabetes Care, Speaker’s Bureau; Self; Dexcom, Inc., Roche Diabetes Care, Stock/Shareholder; Self; Eli Lilly and Company. S. N. Mehta: None. L. M. Laffel: Consultant; Self; AstraZeneca, Boehringer Ingelheim International GmbH, Dexcom, Inc., Dompe, Insulogic LLC, Janssen Pharmaceuticals, Inc., Laxmi Therapeutic Devices, LifeScan, Lilly Diabetes, Medtronic, Provention Bio, Inc. Funding National Institutes of Health (K12DK094721, P30DK036836); Iacocca Family Foundation
ChemInform Abstract: STEREOCHEMICAL STUDIES OF ELIMINATION REACTIONS OF 2‐BROMOBUTANE AND 2,3‐DIBROMOBUTANE OVER ALKALI‐ION EXCHANGED SILICA GELS (1976)

Abstract Während ein teilweiser Austausch von K"‐ gegen Cs ‐Ionen bei der Dehydrobromierung von 2‐Brom‐butan die syn‐Elirninierung in einen anti‐Prozeß umkehrt, zeigt ein Na ‐Li ‐Tausch keine Auswirkung auf den sterischen Verlauf.
MIXIT: The Network Meets the Wireless Channel (2007)

The traditional contract between the network and the lower layers states that the network does routing and the lower layers deliver correct packets. In a wireless network, however, different nodes may hear most bits in a transmission, yet none of them receives the whole packet uncorrupted. The current approach imposes fatesharing on the bits, dropping a whole packet because of a few incorrect bits. In contrast, this paper proposes MIXIT, a new architecture that performs opportunistic routing on groups of correctly received symbols. We show using simulations driven with Software Radios measurements that MIXIT provides $4$x throughput improvement over state-of-the-art opportunistic routing.
Plasma homocysteine level is a risk factor for osteoporotic fractures in elderly patients (2016)

Yuefeng Zhu,1 Jie Shen,2 Qun Cheng,3 Yongqian Fan,1 Weilong Lin1 1Department of Orthopedics, 2Department of Pharmacy, 3Department of Osteoporosis, Huadong Hospital, Fudan University, Shanghai, People’s Republic of China Objective: To study the relationship of plasma homocysteine (Hcy), bone turnover biomarkers (BTB), and bone mineral density (BMD) with osteoporotic fracture (OPF) in elderly people.Methods: Eighty-two patients (aged 65 years or older) admitted to our orthopedics department between October 2014 and May 2015 were randomly divided into three groups: 1) OPF group: 39 cases with the mean age 81.82±5.49 years, which included 24 females and 15 males; 2) high-energy fracture (HEF) group: 22 cases with the mean age 78.88±5.75 years, which included 16 females and six males; 3) non-bone-fracture group: 21 cases with mean age 79.75±5.47 years without bone fracture, which included 14 females and seven males. Plasma Hcy, BTB, and BMD were measured. Analysis of variance and multiple regression analysis were used in the statistical analysis.Results: There was no significant difference in either age or sex among the three groups. There were significant differences in plasma Hcy and hip BMD between the OPF and HEF groups; there was also significant difference in plasma Hcy, 25-(OH) Vit D, and hip BMD between the OPF and non-fracture groups. There was no difference in lumbar spine BMD between the OPF group and the other two groups. There was no significant difference in plasma Hcy, 25-(OH) Vit D, hip or lumbar spine BMD between the HEF and non-fracture group. There was no significant difference in procollagen type I N-propeptide of type I collagen, serum C-terminal cross-linking telopeptide of type I collagen, and parathyroid hormone among the three groups. Plasma Hcy was linearly correlated with age and serum C-terminal cross-linking telopeptide of type I collagen, but not correlated with either hip or lumbar spine BMD or any other BTBs.Conclusion: In this study, we found that the plasma Hcy level in elderly patients with OPF is higher than that of nonosteoporotic patients. It is not correlated with BMD, but positively correlated with bone resorption markers. An increased Hcy level appears to be a risk factor for OPFs in elderly people. Keywords: elderly patient, osteoporosis, fracture, homocysteine, bone mineral density, bone turnover marker
ChemInform Abstract: Large Scale Preparation of Protected 4‐Aminomethylbenzamidine. Application to the Synthesis of the Thrombin Inhibitor, Melagatran. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhancement of Synchronization Between Hippocampal and Amygdala Theta Waves Associated With Pontine Wave Density (2010)

Theta waves in the amygdala are known to be synchronized with theta waves in the hippocampus. Synchronization between amygdala and hippocampal theta waves is considered important for neuronal communication between these regions during the memory-retrieval process. These theta waves are also observed during rapid eye movement (REM) sleep. However, few studies have examined the mechanisms and functions of theta waves during REM sleep. This study examined correlations between the dynamics of hippocampal and amygdala theta waves and pontine (P) waves in the subcoeruleus region, which activates many brain areas including the hippocampus and amygdala, during REM sleep in rats. We confirmed that the frequency of hippocampal theta waves increased in association with P wave density, as shown in our previous study. The frequency of amygdala theta waves also increased with in associated with P wave density. In addition, we confirmed synchronization between hippocampal and amygdala theta waves during REM sleep in terms of the cross-correlation function and found that this synchronization was enhanced in association with increased P wave density. We further studied theta wave synchronization associated with P wave density by lesioning the pontine subcoeruleus region. This lesion not only decreased hippocampal and amygdala theta frequency, but also degraded theta wave synchronization. These results indicate that P waves enhance synchronization between regional theta waves. Because hippocampal and amygdala theta waves and P waves are known to be involved in learning and memory processes, these results may help clarify these functions during REM sleep.
Antitumor Efficacy and Tolerability of Systemically Administered Gallium Acetylacetonate-Loaded Gelucire-Stabilized Nanoparticles (2013)

The widespread clinical success with most gallium compounds in cancer therapy is markedly hampered by lack of tumor specific accumulation, poor tumor permeability and undesirable toxicity to healthy tissues. The aim of this work was to investigate for the first time antitumor mechanism of a new gallium compound (gallium acetylacetonate; GaAcAc) while assessing effectiveness of gelucire-stabilized nanoparticles (NPs) for potential application in gallium-based lung cancer therapy. NPs loaded with GaAcAc (Ga-NPs) were prepared using mixtures of cetyl alcohol with Gelucire 44/14 (Ga-NP-1) or Gelucire 53/13 (Ga-NP-2) as matrix materials. Of special note from this work is the direct evidence of involvement of microtubule disruption in antitumor effects of GaAcAc on human lung adenocarcinoma (A549). In-vivo tolerability studies were based on plasma ALT, creatinine levels and histopathological examination of tissues. The superior in-vivo antitumor efficacy of Ga-NPs over GaAcAc was depicted in marked reduction of tumor weight and tumor volume as well as histological assessment of excised tumors. Compared to free GaAcAc, Ga-NPs showed a 3-fold increase in tumor-to-blood gallium concentrations with minimized overall exposure to healthy tissues. Overall, enhancement of antitumor effects of GaAcAc by gelucire-stabilized NPs coupled with reduced exposure of healthy tissues to gallium would likely ensure desired therapeutic outcomes and safety of gallium-based cancer treatment.
Lethal and Sublethal Activities of Imidacloprid Contribute to Control of Adult Japanese Beetle in Blueberries (2007)

Field-based bioassays and residue profile analysis were used to determine the relative importance of lethal and sublethal effects of imidacloprid on adult Japanese beetle, Popillia japonica Newman, in blueberries, Vaccinium corymbosum L. Field-based bioassays assessed adult mortality and knockdown, and fruit and leaf injury from Japanese beetles exposed to 4-h and 7-d field-aged residues of imidacloprid, and the conventional insecticides azinphosmethyl and esfenvalerate. Azinphosmethyl and imidacloprid caused high levels of mortality when beetles were exposed to blueberry shoots with ripe fruit 4 h postapplication, and all compounds protected blueberry fruit and foliage from beetle feeding. Azinphosmethyl and esfenvalerate caused significant Japanese beetle mortality when adults were exposed to blueberry shoots 7 d postapplication, whereas imidacloprid residues caused effects that protected leaves, although not of ripe fruit. When beetles were exposed to shoots with immature green fruit, relatively more leaf feeding and mortality were observed, suggesting that earlier treatment timings may be most effective for systemic neonicotinoids. Japanese beetle mortality was highly correlated with imidacloprid fruit and leaf surface residues, whereas sublethal feeding deterrent effects were observed after the surface residues diminished. The value of the plant-insect-chemistry model for describing the spatial and temporal dimensions of insecticide modes of activity is discussed in terms of optimizing crop protection.