gebhart/patrepeval huggingface dataset:
Synthesis of [<sup>14</sup>C]amiflamine ‐ an MAO‐A inhibitor (1987)

Abstract Amiflamine ( (S)‐(+)‐2‐(4‐dimethylamino‐2‐methylphenyl)‐1‐methylethylamine) is a potent, selective, and reversible MAO‐A inhibitor. Carbon‐14 labelled amiflamine ( 8 ) with a specific activity of 8.1 mCi/mmol was prepared. The key‐step in the synthesis is a Cu(I)‐catalyzed reaction of an organometallic derivative obtained from compound ( 6 ) with 14 CH 3 I. Also described is the synthesis of the optically active compound ( 6 ).
THE RELATIONSHIP BETWEEN OVARIAN HORMONES AND UTERINE INFECTION IN THE RABBIT. (1962)

SUMMARY The effect of ovarian hormones on the resistance of rabbits to experimental uterine infection was compared in oestrous and pseudopregnant animals and in ovariectomized rabbits treated with oestradiol (10 μg./day for 3 days) or progesterone (5 mg./day for 5 days) or oestradiol + progesterone. A standard period of 8 hr. following inoculation was used after which bacteria flushed from the uterus were assessed by plate count and leucocyte response by packed cell volume ( p.c.v. ). The number of bacteria recovered from the uterine horn of ovariectomized control animals was intermediate between, and significantly different from, pseudopregnant and oestrous animals. The results with ovarian hormone therapy in spayed animals were similar to those of pseudopregnant and oestrous condition. Flushing the uterus prior to inoculation significantly increased the p.c.v. of the uterus of groups under the influence of progesterone and decreased the number of bacteria in these groups. Thus flushing the uterus prior to infection reduced the significant differences in antibacterial activity due to hormone status. The mechanism of the effect of ovarian hormones on resistance to uterine infection is discussed, and it is postulated that a substance is present in the uterus of the rabbit under the influence of progesterone which inhibits leucocyte infiltration and therefore decreases the bactericidal effect.
Mesenchymal Stem Cells: A Promising Tool for Targeted Gene Therapy of Endometriosis (2016)

Endometriosis is a leading, benign gynecological disorder around the world. Last few years have witnessed tremendous growth in the field of endometriosis and endometrial stem-cell research. Despite advancements in the biology and pathology of endometriosis, disease recurrence is still an enigma. Gene therapy holds promise in treating many pathologic conditions including endometriosis. Mesenchymal stem cells (MSCs) serve as ideal candidates for regenerative medicine and cell-based therapies. Owing to their specificity to the endometrium, residing endometrial MSC populations could be utilized as ideal candidates for targeting endometrial disorders. Recently, we demonstrated their flexibility for gene transduction using adenoviral vectors. The review highlights the potential of endometrial MSCs in devising targeted gene therapies for endometriosis.
Poly(vinyl chloride) Ionic Liquid Polymer Electrolyte Based on Bis(fluorosulfonyl)Amide for Sodium Secondary Batteries (2017)

Non-flammable electrolytes have been extensively studied to improve the safety of energy storage devices. In this study, a new ionic liquid polymer electrolyte (ILPE) prepared by a cast technique using poly(vinyl chloride) (PVC) as the host polymer was examined for sodium secondary batteries. The ILPE containing 50 wt% of 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)amide [C2C1im][FSA] ionic liquid showed an ionic conductivity of 5.6 mS cm−1 at 318 K. It remains stable up to 517 K based on 5 wt% loss. Stable sodium metal electrodeposition/dissolution was observed at the cathodic limit of the electrochemical window for the ILPE containing Na[FSA] ([C2C1im][FSA]:Na[FSA]:PVC = 2.0:1.0:1.0 w/w). The anodic limit was observed at around 4.7 V vs. Na+/Na on a Pt working electrode, while on an Al working electrode a higher anodic stability owing to passivation was observed. In the Na/[C2C1im][FSA]-Na[FSA]-PVC/-Na2FeP2O7-cell with the theoretical capacity of 97 mAh g−1, a reversible capacity of 92 mAh g−1 was obtained at 363 K for the Na2FeP2O7 positive electrode. These results suggest great potential of this PVC-based ILPE for constructing very safe sodium secondary batteries.
A semi-adaptive frequency control law for flexible structures (1999)

Piloting flexible structures has become a major concern for control law designers. robustness to parameters variation of the flexible modes is necessary to guarentee stability. The method introduced in this paper makes use of a semi-adaptive frequency control law. Performance for the rigid dynamics of the structure is obtained through a classical linear controller. The adaptive part of the control deals only with updating a controller in charge of following the flexible modes fluctuation. Doing so our global strategy satisfies both the robustness and the performance requirements.
Production sélective de lipopeptides par Bacillus subtilis en bioréacteur à membrane : du génie moléculaire au génie des procédés (2009)

Bacillus subtilis produit grâce a un mecanisme non-ribosomique trois types de lipopeptides, possedant de nombreuses activites biologiques : les iturines, les surfactines et les fengycines ou plipastatines. La synthese de ces molecules est le plus souvent soumise a une regulation complexe. Par ailleurs, leurs proprietes tensioactives rendent la production de ces lipopeptides en bioreacteur aere difficile a cause d’une formation massive de mousse, empechant leur production a grande echelle. Les travaux effectues reposent sur deux approches pour l’optimisation de la production des lipopeptides de B. subtilis. D’un cote, la mise au point d’un procede innovant, base sur la technologie du bioreacteur a contacteur a membrane air/liquide (bioreacteur sans bulles), pour la production de lipopeptides sans la formation de mousse. Les performances de ce bioreacteur a membrane, ont permis par la suite l’elaboration d’un procede integre multimembranaire pour la production, l’extraction et la purification en continu des lipopeptides de B. subtilis. D’un autre cote, une optimisation genetique de la production de surfactine a ete entreprise pour se liberer de la regulation complexe de la synthese de ce lipopeptide et obtenir une souche, derivee de B. subtilis 168, uniquement productrice de surfactine, BBG131. Les differents mutants obtenus dans le cadre de cette optimisation genetique ont egalement permis de demontrer le caractere soit synergique soit antagoniste de la co-production de la surfactine et de la plipastatine sur les proprietes biologiques de B. subtilis. Par ailleurs, l’exploitation du mutant BBG131 dans le procede integre mis au point precedemment a permis la production, l’extraction et la purification de plusieurs dizaines de grammes de surfactine, laissant entrevoir la faisabilite de ce procede integre a l’echelle industrielle
A flat gas-discharge panel TV with good color saturation (1975)

A flat 8-in diagonal gas-discharge color-TV has been fabricated and operated at 5 fL in white with a luminous efficiency of 0.05 lm/W. The contrast ratio was measured at better than 300:1, owing to the special configuration of the discharge cell, and also the careful adjustment of gas loading conditions. The CIE chromaticity coordinates for red, green, and blue (R,G,B) exhibited in the panel were, respectively, (0.56,0.31), (0.22,0.68), and (0,17,0.14)-- reasonably good values considering those of NTSC. The electrical and optical properties of the panel as well as the techniques for real-time TV picture display are discussed.
The Digestion of the Glycoprotein from Pig Gastric Mucus with Pepsin and other Proteolytic Enzymes (1975)

Conference Article| December 01 1975 The Digestion of the Glycoprotein from Pig Gastric Mucus with Pepsin and other Proteolytic Enzymes MICHAEL SCAWEN; MICHAEL SCAWEN 1Department of Biochemistry, Ridley Building, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, U.K. Search for other works by this author on: This Site PubMed Google Scholar ADRIAN ALLEN ADRIAN ALLEN 1Department of Biochemistry, Ridley Building, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1975) 3 (6): 1107–1109. https://doi.org/10.1042/bst0031107 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation MICHAEL SCAWEN, ADRIAN ALLEN; The Digestion of the Glycoprotein from Pig Gastric Mucus with Pepsin and other Proteolytic Enzymes. Biochem Soc Trans 1 December 1975; 3 (6): 1107–1109. doi: https://doi.org/10.1042/bst0031107 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1975 Biochemical Society1975 Article PDF first page preview Close Modal You do not currently have access to this content.
Photochemical Dry Etching of Doped and Undoped Silicon Oxides (1995)

The photochemical dry etching of doped and undoped silicon oxides with and gas has been investigated. Etching rates of several hundred angstroms per minute have been achieved with bulk substrate temperatures below 300°C. Borophosphosilicate glass‐to‐thermal oxide etching rate selectivity is near 1‐to‐1 over a wide range of process conditions. The addition of gas is found to significantly reduce the etching rates of both doped and undoped silicon oxide under these conditions. The photochemical dry cleaning of a 10 to 20 Å chemical oxide layer from trench and via bottoms is discussed.
Gonadotropin and Prolactin Secretion following Intraventricular Administration of Morphine in Gilts (1990)

The effects of central nervous system administration of morphine on secretion of luteinizing hormone (LH), follicle-stimulating hormone, and prolactin were investigated in ovariectomized gilts stereotaxically implanted with lateral ventricular cannulas. In Experiment 1, mean serum LH and follicle-stimulating hormone concentrations and serum LH pulse frequency were unaffected by artificial cerebrospinal fluid administration (P greater than 0.1), but decreased (P less than 0.01) in 8 of 11 gilts when 500 micrograms of morphine were given 3 hr later. Serum LH pulse amplitude was unaffected (P greater than 0.1) by cerebrospinal fluid or morphine injection. In Experiment 2, luteinizing hormone concentrations decreased (P less than 0.0001) and prolactin concentrations increased (P less than 0.0001), but follicle-stimulating hormone concentrations did not change (P greater than 0.1) after 500 micrograms of morphine. Gonadotropin responses to 10 micrograms of gonadotropin-releasing hormone, given 2 hr after intraventricular injection, were similar (P greater than 0.1) for morphine- and cerebrospinal fluid-treated gilts. These results indicate that morphine inhibits LH secretion at the level of the central nervous system, and are consistent with the concept that endogenous opioid peptides participate in the regulation of gonadotropin and prolactin release in pigs.
In-vivo Dynamics of the Human Hippocampus across the Menstrual Cycle (2016)

Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impact of subtle sex-hormonal fluctuations on human hippocampal structure in health is unclear. We tested the feasibility of longitudinal neuroimaging in conjunction with rigorous menstrual cycle monitoring to evaluate potential changes in hippocampal microstructure associated with physiological sex-hormonal changes. Thirty longitudinal diffusion weighted imaging scans of a single healthy female subject were acquired across two full menstrual cycles. We calculated hippocampal fractional anisotropy (FA), a measure sensitive to changes in microstructural integrity, and investigated potential correlations with estrogen. We observed a significant positive correlation between FA values and estrogen in the hippocampus bilaterally, revealing a peak in FA closely paralleling ovulation. This exploratory, single-subject study demonstrates the feasibility of a longitudinal DWI scanning protocol across the menstrual cycle and is the first to link subtle endogenous hormonal fluctuations to changes in FA in vivo. In light of recent attempts to neurally phenotype single humans, our findings highlight menstrual cycle monitoring in parallel with highly sampled individual neuroimaging data to address fundamental questions about the dynamics of plasticity in the adult brain.
Novel Antimicrobial and other Bioactive Metabolites Obtained from Silent Gene Clusters (2015)

International experts summarize the most important research to provide a timely overview of the field. Opening chapters define antibiotic, explain why we need new compounds, outline the applications of antibiotics, both old and new, and describe the producing microbes. Remaining chapters cover topics ranging from antibiotic resistance, toxicity and overuse to novel technologies for antibiotic discovery and antibiotics pipeline.
An approach to 3D pose determination (1996)

The orientation, or pose, of an object is a fundamental property that helps to define the geometrical relationship between the object and its environment. In addition, knowledge of object orientation can also facilitate interpretive and decision-making tasks in a variety of practical domains, including industrial, meteorological, and medical applications. Determining object pose, however, remains an open research question in the fields of graphics and visualization. This article describes a novel yet intuitively simple approach, which we call topological goniometry, to directly determine the pose of a three-dimensional object from 3D data. The topology of interest is that of two-sided surfaces in a three-manifold, and includes objects whose shaped are unaffected by elastic transformations. Algorithmically, topological goniometry is composed of the following major steps. The first analyzes the global topology in order to generate a distribution of 3D coordinate triplets in the proximity of the desired pose axis. Using this set of 3D points, that second step then invokes a “3D Walk” algorithm that considers the local topology to produce a generalized curve representing an estimate of the object's axis of pose. The resultant pose axis is thus not constrained to lie along a straight line but can be generalized 3D curve. The methods are illustrated with a variety of synthetically created models that exhibit duct-like shapes, and are further tested by introducting noise as well as deformations to these models. The approach is also applied to a number of real discrete data obtained from meteorological and medical domains. The results suggest that the appproach is applicable to both real and synthetic datasets and is shown to be robust, computationally efficient, and applicable to a variety of problems. The approach can incorporate context- or application-dependent information about the object of interest by using a set of constraints that guide the process of orientation determination. This article describes the approach, its implementation, and the results obtained with numerous applications.
pH and Temperature-Sensitivities for Gelatin-Poly-isopropylacrylamide Hydrogel (2003)

Interpenetrating hydrogel network that is sensitive to pH value and temperature was synthesized from gelatin(Gel) and N isopropylacrylamide(NIPAM) in a given ratio. The effects of the temperature, pH value on pH and temperature sensitivity of these hydrogels has been investigated respectively .It is shown that the influence of the temperature on the pH sensitivity of the hydrogel depends on the content of the gelatin to NIPAM. The hydrogel with higher content of gelatin is hardly influenced by the temperature, and w PNIPAM 0.50, pH sensiteducing. When PNIPAM takes great content in the gelatin, the temperature sensitivity is negligibly affected by pH.
Selective decrease in low‐<i>M</i><sub>r</sub> HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells (1988)

We have studied the presence of high-mobility-group (HMG) chromatin proteins in undifferentiated F9 mouse teratocarcinoma cells and F9 cells, which were induced to differentiate by treatment with retinoic acid and dibutyryl-cAMP for 5 days. Acetic acid/urea-polyacrylamide gel electrophoresis and reversed-phase HPLC revealed that the induced F9 cells contained 77 and 62% less HMG I and HMG Y, respectively, than their untreated counterparts. The relative amounts of two other low-Mr HMG proteins HMG 14 and HMG 17 remained essentially unchanged and only a minor decrease was observed in the content of one of the high-Mr HMG proteins, HMG 2. The identity of the low-Mr HMG proteins was verified by amino acid analysis or partial sequencing. These results suggest that HMG I and HMG Y are HMG proteins specific for undifferentiated cells.
Factors affecting the performance of the bimorph-based dilatometer for field induced strain measurement of polymer films (2003)

This article gives a detailed discussion about the design and performance of a bimorph-based dilatometer using different sensor heads and platforms both experimentally and theoretically. A current preamplifier in high-pass filter mode was used to optimize the signal and a protective circuit was introduced. The test results demonstrated that the best signal occurred when the lengths of stainless steel pin and bimorph were both 10.0 mm and that the resonant frequency was inversely proportional to the square of the sensor length. Some suggestions for reducing the noise and improving the sensitivity were also provided.
Preliminary characterization of phenomena occurring during single track fabrication in laser additive manufacturing of stainless steel (2014)

Laser additive manufacturing (LAM) is a layer wise fabrication technology which enables the production of complex shaped, individually designed parts with mechanical properties comparable to conventionally manufactured parts. However, the part manufacturing is relatively slow and via this whole production feasibility is not yet totally studied for real series production, as findings from literature shows. It is obvious that many of those studies are carried out in companies “behind locked doors” and because of this whole era of research is suffering of this lack of information. Even though the throughput time from idea to real metal product is short, the throughput time of the actual LAM phase could still be improved to gain more feasible fabrication method. Due to this, it is necessary to increase the build rate in order to improve the process efficiency and also improve whole production feasibility of LAM. It was observed that there are only few public studies about process efficiency of laser additive manufacturing of stainless steel. According to literature, it is possible to improve process efficiency with use of higher laser power and thicker layer. The process efficiency improvement is possible if the effect of process parameter changes in manufactured pieces is known. The manufacturing strategy of track by track and layer by layer involves a lot of different independent and dependent thermal cycles all having an influence on the part and material properties and this way to end result of process. Experimental tests of this study were made with two different machines: with a modified research machine representing EOS EOSINT M-series and with an EOS EOSINT M280. Material used was stainless steel 17-4 PH. Since the quality of manufactured parts depend strongly on each single laser-melted track and each single layer, this study concentrates to investigating the effects of the processing parameters such as scanning speed and laser power on single-track formation. It was concluded that heat input has an important effect on the penetration depth and possibility to melt thicker powder layers. These factors were noticed to be crucial for improving process efficiency. It was concluded in single track tests that some of the tracks have very deep and narrow penetrations into the bulk material. It was also observed that there is possibility to form keyhole in each exposed track with the tested parameters. It was concluded that laser interaction time has effect on the depth of the penetration and keyhole formation, since the penetration depth is increasing while the laser interaction time increases.
Photocorrosion inhibition -of<i>n</i>-GaAs in acidified aqueous iodide solution (1995)

AbstractThe photocorrosion of n-GaAs electrodes in aqueous solutions represents one of the most important factors limiting their application in solar energy conversion. In continuation of previous studies, the corrosion of n-GaAs has been investigated in 0·5M H2SO4 using a pllOtoelectrochemical cell. Illumination of the n-GaAs anode with white light of intensity 20 mW cm-2 generated a saturation photocurrent of 27 mA cm-2 at biasing voltages more positive than +0·45 V(SCE). This current corresponded to hydrogen discharge at the platinum counter electrode and to oxidation of the GaAs surface. When 0·01-6·0M LiI was added to the H2SO4 solution, 12 was formed at the n-GaAs electrode and dissolved in the iodide solution. The onset potential of the photocurrent (Ep) shifted from -0·36 to -0·73 V(SCE) as the concentration was varied from 0·01 to 6·0M I-. Addition of I-3 shifted Ep to more positive values. The extent of corrosion was studied by comparing the ratios of photogenerated I2 and H2. In 0·01, 1·0, and ...
Cystic fibrosis. Target population for lung transplantation in North America in the 1990s. (1992)

Cystic fibrosis is the most common lethal genetic disease occurring in the white population. It is estimated that 3.5% of the 20,000 individuals with cystic fibrosis in North America will die each year of end-stage lung disease. Lung transplantation (heart-lung or double lung) is becoming more frequent as more patients are referred for this procedure. Since January 1988, we have evaluated 60 patients with cystic fibrosis for lung transplantation and have accepted 30 (50%). Nine patients (30%) died while awaiting a donor. Fifteen patients underwent transplantation (13 heart-lung and two double lung procedures). Actuarial survival at 1, 2, and 3 years is 76%. All survivors are without physical limitations. Pulmonary function, as determined by forced vital capacity, forced expiratory volume in 1 second, and arterial blood gas determinations, is within the normal range. Comparing these data with those of a group of patients without cystic fibrosis who underwent transplantation during the same period did not reveal any significant differences with respect to infection, rejection, and outcome. Preliminary data suggest that obliterative bronchiolitis is less prevalent at 1 year in patients with cystic fibrosis (19%) than in those without cystic fibrosis (41%). Patients with cystic fibrosis present a number of challenges. The problems of pleural adhesions from repeated infections, pleurodesis, and previous thoracic procedures are now readily approached through the bilateral thoracosternotomy (clam shell) incision. Insulin-dependent diabetes mellitus and low-dose corticosteroid therapy are no longer considered absolute contraindications. Both septic lungs must be removed at operation, either with heart-lung transplantation or with double lung transplantation. These data support the therapeutic efficacy of lung transplantation for patients with cystic fibrosis.