gebhart/patrepeval huggingface dataset:
Latent capacities for gametogenic cycling in the semelparous invertebrate Nereis. (1994)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
O.R. Comes of Age: A Review of the Work of the Operational Research Branch of the National Coal Board, 1948-1969 (1971)

"O.R. Comes of Age: A Review of the Work of the Operational Research Branch of the National Coal Board, 1948-1969." Journal of the Operational Research Society, 22(4), pp. 383–384
Binding of human serum albumin to PEGylated liposomes: insights into binding numbers and dynamics by fluorescence correlation spectroscopy (2016)

Liposomes for medical applications are often administered by intravenous injection. Once in the bloodstream, the liposomes are covered with a "protein corona", which impacts the behavior and eventual fate of the liposomes. Currently, many aspects of the liposomal protein corona are not well understood. For example, there is generally a lack of knowledge about the liposome binding affinities and dynamics of common types of blood plasma proteins. Fluorescence correlation spectroscopy (FCS) is a powerful experimental technique that potentially can provide such knowledge. In this study, we have used FCS to investigate the binding of human serum albumin (HSA) to standard types of PEGylated fluid-phase liposomes (consisting of DOPC and DOPE-PEG2k) and PEGylated gel-phase liposomes (consisting of DSPC and DSPE-PEG2k) with various PEG chain surface densities. We detected no significant binding of HSA to the PEGylated fluid-phase liposomes. In contrast, we found that HSA bound tightly to the PEGylated gel-phase liposomes, although only a low number of HSA molecules could be accommodated per liposome. Overall, we believe that our data provides a useful benchmark for other researchers interested in studying the liposomal protein corona.
Laboratory Evaluation of Two Bioenergetics Models for Brown Trout (2010)

Abstract Laboratory growth and food consumption data for two size‐classes of brown trout Salmo trutta subjected to three distinct feeding regimes at two temperatures were used to evaluate the ability of two bioenergetics models to predict fish growth. Accuracy of cumulative consumption predictions was also tested for one of the models. Consumption‐dependent prediction error has been commonly observed in bioenergetics models for other fish species; model errors for predicting relative growth rate of individual fish were regressed on observed mean daily consumption rate to assess whether the two bioenergetics models exhibited this type of error. Both models yielded unbiased estimates of brown trout growth that were within 1–12% of observed values across the range of fish sizes, water temperatures, and ration levels tested. For regressions of predicted versus observed final weight, the Bonferroni joint 95% confidence intervals for slope included 1 and confidence intervals for the y ‐intercept included 0 for both models. No significant intermodel differences in percent error for predicting final weight of fish in feeding trials were observed. Predicted cumulative consumption values were within 8–15% of corresponding observed values. Neither model exhibited significant consumption‐dependent error for predicting brown trout growth, in contrast to results of several previous laboratory evaluations of bioenergetics models for other fish species. Absence of consumption‐dependent error in the two brown trout models may be a result of (1) incorporating feeding rate dependence of egestion and excretion into these models and (2) using egestion and excretion parameters that were not borrowed from other species. Results of this evaluation corroborate the utility of these bioenergetics models for predicting growth and consumption for brown trout under the range of fish sizes, water temperatures, and ration levels tested.
Extremely low resonance frequency MOEMS vibration sensors with sub-pm resolution (2014)

The majority of MEMS vibration sensors requires relatively high resonance frequencies of several kHz to avoid mechanical contact of moving parts such as plates or electrodes. In contrast to that, the presented hybrid micro-opto-electro-mechanical system (MOEMS) principle enables displacement sensors applicable at low frequencies. This work describes a distinct MOEMS featuring extremely low resonance frequencies of below 200 Hz. The discussed sensor operates in ambient air without closed loop feedback, extensive electronics, or cooling. Due to the soft suspension of the micro-mechanical sub-system, the fundamental limit, i.e., the Brownian noise floor, is reached for frequencies below the resonance frequency. The related noise equivalent displacement is 1.9 pm/√Hz. Above resonance, the measured noise of 0.86 pm/√Hz, which is equivalent to 0.29 μg/√Hz is dominated by the noise of the electrical components. Also a discussion about feasible improvements regarding the sensitivity and pushing the mechanical resonance frequency below 100 Hz is given.
Disparity Between Proximal and Distal Airway Reactivity During Methacholine Challenge (2011)

There is an increasing awareness of the role of distal airways in the pathophysiology of obstructive lung diseases including asthma and chronic obstructive pulmonary disease. We hypothesize that during induced bronchoconstriction: 1) disparity between distal and proximal airway reactivity may occur; and 2) changes in distal airway function may explain symptom onset in subjects with minimal FEV(1) change. 185 subjects underwent methacholine challenge testing (MCT). In addition to spirometry, oscillometry was performed at baseline and after maximum dose of methacholine; 33/185 also underwent oscillometry after each dose. Oscillometric parameters included resistance at 5 and 20 Hz (R(5), R(20)) and heterogeneity of distal airway mechanics assessed by frequency dependence of resistance 5-20 Hz (R(5-20)) and reactance area (AX). R(5) varied widely during MCT (range -0.8 - 11.3 cmH(2)O/L/s) and correlated poorly with change in FEV(1) (r = 0.17). Changes in R(5) reflected changes in both R(20) and R(5-20) (r = 0.59, p<0.05; r = 0.87, p<0.0001). However, R(20) increased only 0.3 cmH(2)O/L/s, while R(5-20) increased 0.7 cmH(2)O/L/s for every 1cmH(2)O/L/s change in R(5,) indicating predominant effect of distal airway mechanics. 9/33 subjects developed symptoms despite minimal FEV(1) change (<5%), while R(5) increased 42% due to increased distal airway heterogeneity. These data indicate disparate behavior of proximal airway resistance (FEV(1) and R(20)) and distal airway heterogeneity (R(5-20) and AX). Distal airway reactivity may be associated with methacholine-induced symptoms despite absence of change in FEV(1). This study highlights the importance of disparity between proximal and distal airway behavior, which has implications in understanding pathophysiology of obstructive pulmonary diseases and their response to treatment.
47-W, 255-nm source based on second-harmonic generation of a copper-vapor laser in cesium lithium borate (1998)

We have generated 4.7 W of UV (255-nm) radiation with wall plug efficiency of 0.12% by frequency doubling the green (511-nm) output of a kinetically enhanced medium-scale copper-vapor laser (CVL) in cesium lithium borate (CLBO). Frequency doubling in beta -barium borate produced 3.9 W of UV radiation with wall plug efficiency of 0.1%. We found that conversion was better with CLBO because of the reduced constraints on CVL beam quality, less UV absorption, and smaller UV walk-off.
Integrated optical polarisation analyser on planarlightwave circuit (1999)

The authors report an integrated optical polarisation analyser fabricated in a silica waveguide on silicon, which consists of a waveguide-type polarisation beam splitter and an integrated optic 120° hybrid. This is a compact and stable polarisation analyser that does not use any bulk optic components. Polarisation measurement was performed successfully with the fabricated analyser.
The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls (2013)

Increased insight into the mechanisms of action and regulation of this family of enzymes as well as atomic structures of key Nox subunits are expected to give way to a broader spectrum of more potent, efficacious, and specific molecules. These lead molecules will assuredly serve as a basis for drug development aimed at treating a wide array of diseases associated with increased Nox activity.
NMR Solution Structure of ATT<sub>p</sub>, an <i>Arabidopsis thaliana</i> Trypsin Inhibitor<sup>,</sup> (2002)

The three-dimensional structure of the precursor form of the Arabidopsis thaliana trypsin inhibitor (ATT(p), GenBank entry Z46816), a 68-residue (approximately 7.5 kDa) rapeseed class proteinase inhibitor, has been determined in solution at pH 5.0 and 25 degrees C by multinuclear magnetic resonance spectroscopy. The protein contains one alpha-helix and two strands of antiparallel beta-sheet, with a type IV beta-turn connecting the two strands. The alpha-helix and the inhibitory loop are connected to the beta-sheet through three disulfide bridges; a fourth disulfide bridge connects the N- and C-termini. The overall structural topology of ATT(p) is similar to those of the sweet tasting protein brazzein (rmsd of 3.0 A) and the antifungal protein Rs-Afp1 [a knottin protein from radish (Raphanus sativus), rmsd of 2.7 A]. The precursor segment in ATT(p) is disordered, as visualized by the final 20-conformer ensemble and as confirmed by (15)N heteronuclear NOE analysis. The overall fold of ATT(p) is distinct from those of other classes of serine proteinase inhibitors except in the inhibitor loop; therefore, it represents a new inhibitor fold.
Cor triatriatum dexter in two dogs (1993)

Cor triatriatum dexter is a congenital heart defect in which the embryologic right sinus venosus valve persists as a septum within the right atrium. Cor triatriatum dexter was diagnosed in 2 dogs on the basis of clinical signs, two-dimensional echocardiography, and cardiac catheterization. In 1 of the dogs, the condition was successfully treated by surgical resection of the intra-atrial septum. In the second dog, the defect was associated with an incomplete persistent cranial left vena cava and Ebstein's anomaly; surgery was declined.
Carboxylate-Containing Two-Photon Probe for the Simultaneous Detection of Extra- and Intracellular pH Values in Colon Cancer Tissue (2018)

Acidified extracellular pH (pHe) is directly related to various disorders such as tumor invasion and the resistance to drugs. In this study, we developed two-photon-excitable emission ratiometric probes (XBH1-3) for the in situ measurement of pHe. These probes, based on benzimidazole and polar solubilizing groups, exhibited a strong two-photon-induced fluorescence and sensitive blue-to-green emission color changes with p K<sub>a</sub> values of 5.1-5.7. XBH1, containing a carboxylic acid, stained the extracellular region in neutral media; it entered the cell under acidic media, thereby allowing a precise measurement of the extra- and intra-cellular pH values in the acidified tissue. XBH2, containing the sulfonate peripheral unit, facilitated the monitoring of the pHe value only. Ratiometric two-photon microscopy imaging revealed that XBH1 can directly monitor the pH values both inside and outside the cells in colon cancer tissue; there is also the morphological aspect. This could be useful for cancer analyses and drug development.
Radiographer Delivered Fluoroscopy Reduces Radiation Exposure During Endoscopic Urological Procedures. (2016)

Radiographer delivered fluoroscopy could reduce the patient's exposure to ionising radiation for some urological procedures.
Differential Activation of the ER Stress Factor XBP1 by Oligomeric Assemblies (2012)

Several neurodegenerative disorders are characterized by protein misfolding, a phenomenon that results in perturbation of cellular homeostasis. We recently identified the protective activity of the ER stress response factor XBP1 (X-box binding protein 1) against Amyloid-ß1-42 (Aß42) neurotoxicity in cellular and Drosophila models of Alzheimer's disease. Additionally, subtoxic concentrations of Aß42 soluble aggregates (oligomers) induced accumulation of spliced (active) XBP1 transcripts, supporting the involvement of the ER stress response in Aß42 neurotoxicity. Here, we tested the ability of three additional disease-related amyloidogenic proteins to induce ER stress by analyzing XBP1 activation at the RNA level. Treatment of human SY5Y neuroblastoma cells with homogeneous preparations of α-Synuclein (α-Syn), Prion protein (PrP106-126), and British dementia amyloid peptide (ABri1-34) confirmed the high toxicity of oligomers compared to monomers and fibers. Additionally, α-Syn oligomers, but not monomers or fibers, demonstrated potent induction of XBP1 splicing. On the other hand, PrP106-126 and ABri1-34 did not activate XBP1. These results illustrate the biological complexity of these structurally related assemblies and argue that oligomer toxicity depends on the activation of amyloid-specific cellular responses.
ChemInform Abstract: WEGE ZUR UMWANDLUNG VON D‐XYLOSE, HEXURONSAEUREN ODER L‐ASCORBINSAEURE IN 2‐FURALDEHYD (1972)

Abstract D‐Xylose, D‐Glucuronsäure, L‐S0rburonsäure, L‐Ascorbinsäure und 2‐Oxo‐D‐ arabinohexonsäure werden bei Behandlung mit Säuren in 2‐Furaldehyd übergeführt.
Postmortem Clomipramine: Therapeutic or Toxic Concentrations? (1994)

Postmortem blood and liver concentrations of clomipramine were determined in ten cases by high performance liquid chromatography (HPLC). Blood concentrations ranged from 0.21 to 4.9 mg/L, and liver concentrations from 7.0 to 320 mg/kg. Two cases associated with clomipramine toxicity were clearly differentiated from other cases by the analysis of liver. The concentrations of clomipramine in these two cases were 3.3 and 1.8 mg/L in blood, and 280 and 320 mg/kg in liver. The liver concentrations were 10 to 30 fold greater in the deaths associated with drug toxicity compared with the other cases. One case, where cardiac blood was collected in place of femoral blood, showed a high blood concentration (4.9 mg/L), but an arguably therapeutic liver concentration (13 mg/kg). The analysis of femoral blood together with liver provides the best guide as to the significance of post-mortem clomipramine concentrations.
Spectrometric elucidation of acrimarines, the first naturally occurring acridone–coumarin dimers (1990)

The structures of acrimarine-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), and -G (7), novel acridone alkaloids carrying a coumarin unit, from the root of Citrus funadoko have been elucidated by spectrometric studies using 1H-13C long-range COSY experiments; acrimarine-A (1) and -F (6) have also been synthesized from the corresponding acridones and coumarins.
A novel mode of coordination for phosphorus (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel mode of coordination for phosphorusAnthony J. Arduengo III, H. V. Rasika Dias, and Joseph C. CalabreseCite this: J. Am. Chem. Soc. 1991, 113, 18, 7071–7072Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/ja00018a073https://doi.org/10.1021/ja00018a073research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine (2018)

The ongoing progress in the development of hydrogel technology has led to the emergence of materials with unique features and applications in medicine. The innovations behind the invention of nanocomposite hydrogels include new approaches towards synthesizing and modifying the hydrogels using diverse nanofillers synergistically with conventional polymeric hydrogel matrices. The present review focuses on the unique features of various important nanofillers used to develop nanocomposite hydrogels and the ongoing development of newly hydrogel systems designed using these nanofillers. This article gives an insight in the advancement of nanocomposite hydrogels for nanomedicine.
ChemInform Abstract: PHOTOCHEMICAL FORMATION OF METHYLENECYCLOPROPANE ANALOGS. 10. PHOTOCHEMICAL ELIMINATION OF NITROGEN FROM 1,4‐DIHYDRO‐1‐PHENYL‐5H‐TETRAZOL‐5‐ONES AND THIONE ANALOGS. BENZIMIDAZOLONES AND CARBODIIMIDES (1985)

Abstract Die Photolyse der entsprechenden Tetrazolinone (I) und (II) bzw. der Thione (III) führt zu den Benzimidazolinonen (V) bzw. den (als blaßgelbe Öle anfallenden) Carbodiimiden (VI), die zu den gut kristallisierenden Harnstoffderivaten (VII) hydratisiert werden [das bei der Photolyse von (VIII) entstehende N‐Phenyl‐carbodiimid lagert sich in Phenylcyanamid um (Ausb. 73°C /o)].
Quasi-two-dimensional transmission line model (QTD-TLM) for planar ohmic contact studies (2002)

An analytical quasi-two-dimensional transmission tine model (QTD-TLM) has been formulated to more accurately extract the specific contact resistance (/spl rho//sub c/) of ohmic contacts than the conventional one-dimensional TLM (1D-TLM). Similar to 1D-TLM, the extraction of /spl rho//sub c/ using QTD-TLM is straightforward. By means of the conformal mapping technique, the two-dimensional (2-D) (or lateral) current flow and current crowding, owing to the presence of a gap between the TLM mesa and contacts, are jointly incorporated into our model using a single shunt resistor. QTD-TLM is generalized as it is applicable to a variety of contact dimensions and gap widths, and to both alloyed and nonalloyed contacts. The validity of QTD-TLM has been verified experimentally using two alloyed and two nonalloyed ohmic contacts, and by comparison with results from a 2-D numerical model.
AAPG-SEPM Gulf of Mexico Transect Project: ABSTRACT (1995)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Investigation of Saturable Absorbance Characteristics of Film Composites with SWNT and Graphene for Fiber Laser Pulse Generation (2015)

Saturable absorption (SA) of film composites based on carboxymethylcellulose (CMC) polymer with single-walled carbon nanotubes (SWNTs) and graphene (GR) was studied by the Z-and P-scan methods with femtosecond probing pulses at a wavelength of 1.06 μm. The values of the saturation intensities for composites GR-CMC and SWNT-CMC were determined. The optical and thermal damage thresholds of the composites were measured. Q-switching stability limits for passive mode locking in fiber laser with SWNT-CMC SA were analyzed.
Fas Ligand Engagement of Resident Peritoneal Macrophages In Vivo Induces Apoptosis and the Production of Neutrophil Chemotactic Factors (2001)

Fas ligand (FasL) is a potent proapoptotic type-II transmembrane protein that can cause cell death in Fas+ target populations. Despite the presumed "silent" nature of apoptotic cell death, forced expression of FasL can induce a dramatic inflammatory response. To elucidate the in vivo mechanism(s) linking FasL and inflammation, we used a membrane-bound cell-free form of FasL (mFasL-vesicle preparation (VP)). We found that i.p. injection of FasL-microvesicles led to the rapid activation and subsequent demise of Mac1(high) resident peritoneal macrophages. Apoptosis of Mac1(high) peritoneal macrophages was observed within 0.5 h of mFasL-VP injection and correlated with the detection of increased macrophage inflammatory protein (MIP)-2 levels in peritoneal lavage fluid as well as induced RNA expression of IL-1beta, MIP-2, MIP-1alpha, and MIP-1beta. In vitro culture of purified peritoneal populations identified Mac1(high) cells as the major cytokine/chemokine producers in response to mFasL-VP. Purified Mac1(high) cells exposed to FasL could restore the ability of Fas-deficient mice to mount an inflammatory response. Our data demonstrate that the FasL-mediated inflammatory response starts with the production of proinflammatory mediators by preapoptotic resident tissue macrophages and suggest a general mechanism responsible for neutrophil inflammation seen in cases of FasL-expressing allografts.
Stable P-heterocylic carbenes : scope and limitations (2007)

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