gebhart/patrepeval huggingface dataset:
Mycobacterial (2011)

Trustworthy guidance spanning every aspect of adolescent health care. Unlike other adolescent medicine references, the all-new AAP Textbook of Adolescent Care is an action-oriented working tool expressly built for efficient, on-target clinical problem-solving. Broad scope - Nearly 200 chapters cover physical growth and development, examination and laboratory screening, sexual development, puberty, obesity, sleep disorders, adolescent dermatology and much more. Clear management guidelines - Provides step-by-step recommendations: What to do, How to do it; When to admit, When to treat, When to refer. Evidence-based approach - Treat patients and counsel parents with high confidence. Excellent study reference - for the pediatric or internal medicine boards. Integrated companion resources - Use with complementary AAP resources: AAP Textbook of Pediatric Care, Tools for Practice, and Pediatric Care Online.
A novel "Follow the master" filter (1977)

Active-R filters have their pole-frequencies directly dependent on the gain-bandwidth (GB) product of the operational amplifiers used. A novel technique, by which the pole-frequencies of the system are made to depend on a stable reference-frequency times the ratio of the GB products, rather than their absolute values, is given.
Herbal medication: potential for adverse interactions with analgesic drugs (2002)

The use of herbal supplements in the US has increased dramatically in recent years. These products are not regulated by the Food and Drug Administration (FDA) with the same scrutiny as conventional drugs. Patients who use herbal supplements often do so in conjunction with conventional drugs. This article is a review of potential adverse interactions between some of the commonly used herbal supplements and analgesic drugs. Non-steroidal anti-inflammatory drugs (NSAIDs), particularly aspirin, have the potential to interact with herbal supplements that are known to possess antiplatelet activity (ginkgo, garlic, ginger, bilberry, dong quai, feverfew, ginseng, turmeric, meadowsweet and willow), with those containing coumarin (chamomile, motherworth, horse chestnut, fenugreek and red clover) and with tamarind, enhancing the risk of bleeding. Acetaminophen may also interact with ginkgo and possibly with at least some of the above herbs to increase the risk of bleeding. Further, the incidences of hepatotoxicity and nephrotoxicity may be augmented by acetaminophen when concomitantly used with the potentially hepatotoxic herbs Echinacea and kava, and with herbs containing salicylate (willow, meadowsweet), respectively. The concomitant use of opioid analgesics with the sedative herbal supplements, valerian, kava and chamomile, may lead to increased central nervous system (CNS) depression. The analgesic effect of opioids may also be inhibited by ginseng. It is suggested that health-care professionals should be more aware of the potential adverse interactions between herbal supplements and analgesic drugs, and take appropriate precautionary measures to avoid their possible occurrences. However, as most of the interaction information available is based on individual case reports, animal studies and in vitro data, further research is needed to confirm and assess the clinical significance of these potential interactions.
Simple Method to Fabricate an Biocompatible Antibacterial Surface on a Versatile Substrate through an Antiadhesion Approach (2012)

Abstract The synthesized polymer, poly(ethoxyethyl glycidyl ether-co-allyl glycidyl ether)-g-catechol (PEAC), has both vinyl and catechol functional side groups. Due to the pendant catechol groups, PEAC could be immobilized on various substrates tightly. Furthermore, the backbone of PEAC, poly(ethylene glycol), gives the PEAC-modified substrates good antiadhesion performance to bacteria. The antibacterial surface fabricated by this way is very different from the conventional method to empower material to have antibacterial properties directly or indirectly by killing bacteria absorbed.
Serum Cholesterol Levels in Rats Fed Skim Milk Fermented by <i>Lactobacillus Acidophilus</i> (1982)

ABSTRACT The effects of reconstituted skim milk, and the same fermented by Lactobacillus acidophilus , were tested in rats. Rats were fed a stock diet and drinking water containing one of three milk treatments: (1) no supplementary milk; (2) 10% milk; or (3) 10% milk fermented by L. acidophilus. After 4 wk, rats receiving the fermented milk had lower (P < 0.05) serum cholesterol levels (65 mg/dl) than did the water‐fed (78 mg/dl) or milk‐fed (79 mg/dl) rats. Weight gain, feed intake, liver lipid contents and fecal lactobacilli counts were not different among treatment groups. Data indicate that factors influencing serum cholesterol levels were produced during fermentation of the milk.
Genomic Targets of Nuclear Estrogen Receptors (2004)

Estrogen influences the physiology of many target tissues in both women and men. The long-term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) functioning as DNA-binding transcription factors. Tissue-specific responses to estrogen therefore result from regulation of different sets of genes. However, it remains perplexing as to what regulatory sequence contexts specify distinct genomic responses. First, this review classifies estrogen response sequences in mammalian target genes. Of note, around one third of known human target genes associate only indirectly with ER, through intermediary transcription factor(s). Then, computational approaches are presented both for refining direct ER-binding sites and for formulating hypotheses regarding the overall genomic expression pattern. Surprisingly, limited evolutionary conservation of specific estrogen-responsive sites is observed between human and mouse. Finally, consideration of the cellular functions of regulated human genes suggests links between particular biological roles and specific types of estrogen response elements, although with the important caveat that only a restricted set of target genes is available. These analyses support the view that specific, hormone-driven gene expression programs can result from the interplay of environmental and cellular cues with the distinct types of estrogen-response sequences.
Using a bacteriocin structure to engineer a phage lysin that targets <i>Yersinia pestis</i> (2012)

Purified phage lysins present an alternative to traditional antibiotics and work by hydrolysing peptidoglycan. Phage lysins have been developed against Gram-positive pathogens such as Bacillus anthracis and Streptococcus pneumoniae, where the peptidoglycan layer is exposed on the cell surface. Addition of the lysin to a bacterial culture results in rapid death of the organism. Gram-negative bacteria are resistant to phage lysins because they contain an outer membrane that protects the peptidoglycan from degradation. We solved crystal structures of a Yersinia pestis outer-membrane protein and the bacteriocin that targets it, which informed engineering of a bacterial-phage hybrid lysin that can be transported across the outer membrane to kill specific Gram-negative bacteria. This work provides a template for engineering phage lysins against a wide variety of bacterial pathogens.
Encroachment on the private practice of medicine. (1976)

<B>Main Topics</B>:<BR>Information includes demographic details, smoking behaviour, cigarette and rolling tobacco brands used.
Oxalate ions and calcium oxalate crystal‐induced up‐regulation of osteopontin and monocyte chemoattractant protein‐1 in renal fibroblasts (2006)

These results indicate that fibroblasts respond to high Ox and CaOx crystals by up-regulating specific pathways producing pro-inflammatory conditions. Migration of monocytes/macrophages to sites of interstitial crystal deposits can lead to localized interstitial inflammation and fibrosis.
Pathology of Hodgkinʼs disease (1994)

This review addresses several current questions about Hodgkin's disease (HD): 1) Does HD represent a single disease or multiple diseases? 2) What is the role of cytokines in HD? 3) What is the nature of the Reed-Sternberg cell? 4) How are Epstein-Barr virus (EBV) and oncogenes (bcl-2, c-myc, and p53) involved in the pathogenesis of HD? Nodular lymphocyte predominance HD appears to be a distinct clinicopathologic entity. Cytokines attract inflammatory cells, induce fibrosis, upregulate oncogenes and adhesion molecules, cause systemic symptoms, and mediate immune suppression. Reed-Sternberg cells are derived from B and T lymphocytes in most instances, although an alternative origin from a follicular dendritic reticulum cell has been proposed. EBV is an etiologic agent in some but not all HD cases. EBV gene products confer a growth advantage on Reed-Sternberg cells. The bcl-2 and p53 oncogenes protect Reed-Sternberg cells from apoptosis and are not directly upregulated by EBV.
A comparison of helium dilution and plethysmography in measuring static lung volumes (2008)

In order to examine the usefulness of the multi breath helium dilution method (MB) it was compared to the single breath helium dilution method (SB) and body plethysmography (BP). Residual volume (RV), total lung capacity (TLC) and vital capacity (VC) were measured in seventeen subjects with obstructive (11) or restrictive (6) lung disease and four normal subjects. With information from professional literature and current periodicals, advantages and disadvantages with all three methods were compared. ANOVA and Student's t-test were performed on the measurement results. The results of the statistical tests tell us there are differences among the methods in the group of obstructive patients. They also reveal a notable difference between the MB and SB methods when measuring the same parameter. In addition, it was noted that none of the existing sets of prediction equations fulfill the requirements established on high quality lung function testing. Although a thorough evaluation of the reproducibility of the method is still required, it appears to be a viable alternative to body plethysmography. We claim that measuring the above mentioned static lung volumes with only the single breath helium dilution method cannot be considered a satisfactory practice.
In situ demonstration of phosphorylated c‐jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skin (2001)

Ultraviolet B (UVB) irradiation is known to induce activation of cellular stress response pathways in cultured cells or intact human skin, as demonstrated by phosphorylation of MAP kinase family members and up- or down-stream targets, using biochemical assays. This study demonstrates by immunohistochemistry that low-dose UVB irradiation of normal human skin induces rapid and reversible phosphorylation of c-jun (a target of c-jun N-terminal kinase) and p38 mitogen activated protein kinase (p38 MAP kinase). Phosphorylation was maximal at 4–8 h and returned to normal levels at 48 h after irradiation. Nuclear localization of these phosphorylated substrates was found using antisera against the epitope containing the phosphorylated serine-73 of c-jun, and the dually phosphorylated epitope (threonine-180 and tyrosine-182) of p38 MAP kinase. Nearly all epidermal cells were positive for c-jun phosphorylation, whereas p38 phosphorylation was seen predominantly in the differentiated layers. In contrast to the massive activation of c-jun and p38, only a small population of the suprabasal cells showed nuclear translocation of nuclear factor kappa B (NFκB), and a few scattered cells became apoptotic, as determined by TUNEL (TdT mediated dUTP nick end labelling) staining. The expression of involucrin and skin-derived anti-leukoproteinase (SKALP)/elafin, two genes putatively under control of the c-jun and p38 pathways, was found to be increased. These findings establish the first cellular localization of UVB-induced protein phosphorylation of stress response proteins in human epidermis, thereby providing a link between cellular activation and gene expression in defined cell populations. Copyright © 2000 John Wiley & Sons, Ltd.
Comparison of once and twice daily administration of acebutolol in hypertension. (1980)

1 Thirteen hypertensive patients completed a double-blind comparison of placebo, acebutolol 200 mg twice daily and acebutolol 400 mg once daily, administered for 4 weeks in random order. 2 Blood pressure and heart rate were significantly reduced by both acebutolol treatments. The mean reduction of resting pressure 12 h after 200 mg twice daily (12/7 mmHg) was similar to that 24 hr after 400 mg once daily (13/9 mmHg). 3 Compared to placebo, reductions in exercise heart rate and systolic pressure at 12 h after 200 mg twice daily and 24 h after 400 mg once daily were significant and similar. 4 Beta-adrenoceptor antagonism was also assessed by inhibition of the heart rate response to sublingual glyceryl trinitrate taken in the standing position. Both acebutolol treatments reduced the response; the reduction after twice daily treatment (mean 25 beats/min) was significantly greater than after once daily treatment (mean 19 beats/min). 5 There was no difference in blood pressure control between acebutolol administered once and twice daily in a total daily dose of 400 mg.
Surface acoustic wave devices for chemical analysis (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface acoustic wave devices for chemical analysisDavid S. Ballantine, Jr. and Hank WohltjenCite this: Anal. Chem. 1989, 61, 11, 704A–715APublication Date (Print):June 1, 1989Publication History Published online22 September 2008Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/ac00186a001https://doi.org/10.1021/ac00186a001research-articleACS PublicationsRequest reuse permissionsArticle Views803Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
P2 receptors in the regulation of renal transport mechanisms (2007)

Extracellular nucleotides (e.g., ATP) regulate physiological and pathophysiological processes through activation of nucleotide P2 receptors in the plasma membrane. Examples include such diverse processes as communication from taste buds to gustatory nerves, platelet aggregation, nociception, or neutrophil chemotaxis. Over approximately the last 15 years, evidence has also accumulated that cells in renal epithelia release nucleotides in response to physiological stimuli and that these nucleotides act in a paracrine and autocrine way to activate P2 receptors and play a significant role in the regulation of transport mechanisms and cell volume regulation. This review discusses potential stimuli and mechanisms involved in nucleotide release in renal epithelia and summarizes the available data on the expression and function of nucleotide P2 receptors along the native mammalian tubular and collecting duct system. Using established agonist profiles for P2 receptor subtypes, significant insights have been gained particularly into a potential role for P2Y(2)-like receptors in the regulation of transport mechanisms in the collecting duct. Due to the lack of receptor subtype-specific antagonists, however, the in vivo relevance of P2 receptor subtypes is unclear. Studies in gene knockout mice provided first insights including an antihypertensive activity of P2Y(2) receptors that is linked to an inhibitory influence on renal Na(+) and water reabsorption. We are only beginning to unravel the important roles of extracellular nucleotides and P2 receptors in the regulation of the diverse transport mechanisms of the kidney.
Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle (1974)

Using an assay for jejunal crypt stem cell survival, the biological effectiveness of two cyclotron-produced neutron beams relative to one another and to 60Co γ-radiation has been determined at doses of the order used per fraction in clinical trials of neutrons. Dose survival curves were determined using up to 5 doses of neutrons and up to 20 dose-fractions of γ rays. There is little sparing of jejunal mucosa as a result of repair of sublethal injury during intervals between neutron dose fractions, whereas such repair is considerable when γ-ray doses are fractionated. The response of jejunal crypt stem cells to both neutron and gamma radiation shows considerable variation throughout the division cycle, but the variation is less with neutrons.
Grammar in the early middle ages (1993)

Preview this article: Grammar in the Early Middle Ages: A Bibliography, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/hl.20.1.04law-1.gif
Super‐resolution imaging for cell biologists (2015)

The recent 2014 Nobel Prize in chemistry honored an era of discoveries and technical advancements in the field of super‐resolution microscopy. However, the applications of diffraction‐unlimited imaging in biology have a long road ahead and persistently engage scientists with new challenges. Some of the bottlenecks that restrain the dissemination of super‐resolution techniques are tangible, and include the limited performance of affinity probes and the yet not capillary diffusion of imaging setups. Likewise, super‐resolution microscopy has introduced new paradigms in the design of projects that require imaging with nanometer‐resolution and in the interpretation of biological images. Besides structural or morphological characterization, super‐resolution imaging is quickly expanding towards interaction mapping, multiple target detection and live imaging. Here we review the recent progress of biologists employing super‐resolution imaging, some pitfalls, implications and new trends, with the purpose of animating the field and spurring future developments.
Schottky-barrier height of ideal metal contacts to GaAs (1984)

The Schottky-barrier height φB of ideal (no interfacial oxide) contacts to GaAs has been measured for a diverse group of eleven metals, Cu, Pd, Ag, Au, Al, Ti, Pb, Bi, Ni, Cr, and Fe, by using current-voltage and capacitance-voltage techniques. The contacts were formed by metal evaporation in ultrahigh vacuum onto clean (100) surfaces of both n-type and p-type GaAs. For n-type contacts φB ranged from 0.96 to 0.72 eV, in the metal order listed above; for p-type contacts φB ranged from 0.45 to 0.62 eV. No simple correlation was found between φB and metal work function nor between φB and the chemical reactivity at the metal-GaAs interface.
Injected Absorption in Germanium (1953)

When minority carriers are injected into germanium the density of current carriers is increased. This forms the basis of transistor action. The increased number of carriers is expected to cause increased absorption in the infra-red region of the spectrum. This effect has been observed and studied as a function of wavelength, injected current, frequency and other relevant parameters. The basic theory of the effect is discussed and is found to be substantially in agreement with the experimental results. Possible practical applications of the effect are described.
Energy and Water Monitoring System for Smart Metering and Consumer Awareness (2015)

Smart meter facilitates real-time communication between the customer and the utility company offering various advantages to both the suppliers and the consumers. Problems such as meter reading, information on energy and water usage, demand requirements, varying tariff, billing and theft can be solved through smart metering. This paper presents the design and implementation of an automatic electricity and water meter system. The system consists of the smart meter comprising a GSM board, Arduino microcontroller, a clamp current sensor together with a water flow sensor for measuring the amount of electricity and water consumed.  An in-house display which communicates with the smart meter via a RF link offers the consumers access to real-time data of their consumption.  The in-house display system, which requires authentication to communicate with the smart meter, also offers the users to set usage limits with short message service (SMS) alerts, and turn on/off the supply of electricity or water. The usage details are also sent to the suppliers via a SMS for billing purpose. The supplier also has access to the smart meter system, as they can set usage limits or cut off supply in cases such as bills not being paid.
Instrumented testing of functional knee braces (1986)

The ability of seven functional knee braces to control anterior tibial displacement in three severely lax ACL deficient knees using two instrumented testing devices was studied. Some braces were statistically shown to be much better in this regard than others, but not all data obtained was statistically significant. This material should aid one in determining which braces offer the greatest degree of control of anterior tibial displacement in patients with ACL insufficiency.
Packet access mechanisms for cellular radio (1993)

The paper reviews the findings of work completed in RACE Mobile Telecommunications Project 1043 on the suitability of packet access mechanisms for mixed services in the Universal Mobile Telecommunication System. A first order comparison of random and scheduled access is provided and conditions under which these mechanisms provide an attractive alternative to channel allocation for call duration are specified. It is concluded that packet reservation multiple access (PRMA) is an attractive candidate for mixed services over a range of cell sizes as it can accommodate fixed channel access, reserved channel access and random channel access.
Quantum noise-correlated operation of electrically coupled semiconductor light emitters (1992)

Electrically coupled light-emitting diodes have been configured to demonstrate multiple light beams with correlated sub-shot-noise intensity fluctuations. Photocurrent covariance measurements of the two light beams from a pair of series-connected diodes show a positive correlation, similar to that observed with nonlinear crystal down-converters. Shunt-connected diodes are shown to generate negatively correlated light beams.
Innovative methodology for intercomparison of radionuclide calibrators using short half-life<i>in situ</i>prepared radioactive sources (2014)

The methodology described in this paper showed to have a good potential for accurate (3%) radionuclide calibrators intercomparison studies for(99m)Tc between Nuclear Medicine centers without source transfer and can easily be adapted to other short half-life radionuclides.