gebhart/patrepeval huggingface dataset:
Bonding and Energy Dissipation in a Nanohook Assembly (2003)

Combining total energy and molecular dynamics calculations, we explore the suitability of nanotube-based hooks for bonding. Our results indicate that a large force of 3.0 nN is required to disengage two hooks, which are formed by the insertion of pentagon-heptagon pairs in a (7,0) carbon nanotube. Nanohooks based on various nanotubes are resilient and keep their structural integrity during the opening process. Arrays of hooks, which are permanently anchored in solid surfaces, are a nanoscale counterpart of velcro fasteners, forming tough bonds with a capability of self-repair.
Copper(I) complexes with bidentate tertiary phosphine ligands: solution chemistry and antitumor activity (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopper(I) complexes with bidentate tertiary phosphine ligands: solution chemistry and antitumor activitySusan J. Berners-Price, Randall K. Johnson, Christopher K. Mirabelli, Leo F. Faucette, Francis L. McCabe, and Peter J. SadlerCite this: Inorg. Chem. 1987, 26, 20, 3383–3387Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/ic00267a034https://doi.org/10.1021/ic00267a034research-articleACS PublicationsRequest reuse permissionsArticle Views1337Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Characteristic impedance extraction using calibration comparison (2001)

A robust line impedance identification method is presented in this paper. It determines the characteristic impedance of on-wafer thru-line-reflect (TLR) standards measured after an initial off-wafer line-reflect-match or TLR calibration. The only assumption made is that the obtained trans-wafer error boxes are a cascade of a symmetric probe-related disturbance and a change in reference impedance. The proposed method yields an unbiased estimate of the complex characteristic impedance. Results from coplanar lines on a medium resistivity silicon substrate support the made assumption.
Flash Species-selective Analysis by Multicapillary Gas Chromatography with Microwave Induced Plasma Atomic Spectrometric Detection (1997)

Multicapillary column isothermal gas chromatography with element-selective detection has been shown to allow the ultra-rapid (<30 s instead of about 10 min) analysis of non-polar compounds with boiling-points of 200–300 °C, without sacrificing the resolution and efficiency of conventional capillary GC with oven temperature gradient programming. An example of speciation analysis for butyltin compounds in a PACS-1 certified reference sediment is shown.
Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1 (2010)

Combined deficiencies of poly(ADP)ribosyl polymerase 1 (PARP1) and ataxia telangiectasia mutated (ATM) result in synthetic lethality and, in the mouse, early embryonic death. Here, we investigated the genetic requirements for this lethality via analysis of mice deficient for PARP1 and either of two ATM-regulated DNA damage response (DDR) factors: histone H2AX and 53BP1. We found that, like ATM, H2AX is essential for viability in a PARP1-deficient background. In contrast, deficiency for 53BP1 modestly exacerbates phenotypes of growth retardation, genomic instability, and organismal radiosensitivity observed in PARP1-deficient mice. To gain mechanistic insights into these different phenotypes, we examined roles for 53BP1 in the repair of replication-associated double-strand breaks (DSBs) in several cellular contexts. We show that 53BP1 is required for DNA-PKcs-dependent repair of hydroxyurea (HU)-induced DSBs but dispensable for RPA/RAD51-dependent DSB repair in the same setting. Moreover, repair of mitomycin C (MMC)-induced DSBs and sister chromatid exchanges (SCEs), two RAD51-dependent processes, are 53BP1 independent. Overall, our findings define 53BP1 as a main facilitator of nonhomologous end joining (NHEJ) during the S phase of the cell cycle, beyond highly specialized lymphocyte rearrangements. These findings have important implications for our understanding of the mechanisms whereby ATM-regulated DDR prevents human aging and cancer.
A guided-wave optical switch controlled by a micro-electro-mechanical cantilever (2002)

Micro-electro-mechanical (MEM) systems hold great promise for replacing movable mirror optical switch in telecommunications applications primarily owing to their greatly reduced weight and the ease for mass production. Here we report a MEM actuated integrated optic switch that is fabricated on a silicon substrate and is capable of moderate scale integration. The switching action is based on electro-static bending of a cantilever arm containing two vertically aligned waveguides. The device is implemented by making use of planar waveguide silicon nitride and silicon oxy-nitride technology.
Benarthin: A new inhibitor of pyroglutamyl peptidase. I. Taxonomy, fermentation, isolation and biological activities. (1992)

We found benarthin, a new inhibitor of pyroglutamyl peptidase, in the fermentation broth of Streptomyces xanthophaeus MJ244-SF1. It was purified by column chromatography and centrifugal partition chromatography (CPC) and then was isolated as a colorless powder. The binding of benarthin was competitive with substrate and its inhibition constant (Ki) was 1.2 x 10(-6) M.
Self consistent low pressure RF (radiant flux) discharge modelling: Comparisons with experiments in clean and dusty plasmas (1994)

Abstract
The subcellular localization of E2F-4 is cell-cycle dependent (1997)

The E2F family of transcription factors plays a crucial role in cell cycle progression. E2F activity is tightly regulated by a number of mechanisms, which include the timely synthesis and degradation of E2F, interaction with retinoblastoma protein family members (“pocket proteins”), association with DP heterodimeric partner proteins, and phosphorylation of the E2F/DP complex. Here we report that another mechanism, subcellular localization, is important for the regulation of E2F activity. Unlike E2F-1, -2, or -3, which are constitutively nuclear, ectopic E2F-4 and -5 were predominantly cytoplasmic. Cotransfection of expression vectors encoding p107, p130, or DP-2, but not DP-1, resulted in the nuclear localization of E2F-4 and -5. Moreover, the transcriptional activity of E2F-4 was markedly enhanced when it was invariably nuclear. Conversely, it was reduced when the protein was excluded from the nucleus, implying that E2F-4 transcription function depends upon its cytological location. In keeping with this, the nuclear/cytoplasmic ratios of endogenous E2F-4 changed as cells exited G 0 , with high ratios in G 0 and early G 1 and a progressive increase in cytoplasmic E2F-4 as cells approached S phase. Thus, the subcellular location of E2F-4 is regulated in a cell cycle-dependent manner, providing another potential mechanism for its functional regulation.
Quantum Imaging of Nonlocal Spatial Correlations Induced by Orbital Angular Momentum (2005)

Through scanned coincidence counting, we probe the quantum image produced by parametric down-conversion with a pump-beam carrying orbital angular momentum. Nonlocal spatial correlations are manifested through splitting of the coincidence spot into two.
Reactions of <i>p</i>-Benzoquinone with Sulfur Nucleophiles (2008)

Corrected by: Reactions of p-Benzoquinone with Sulfur NucleophilesSynthesis 2012; 44(21): 3400-3400DOI: 10.1055/s-0032-1316795
Segmentation and Estimation of Image Region Properties through Cooperative Hierarchial Computation (1981)

The task of segmenting an image and that of estimating properties of image regions may be highly interdependent. The goal of segmentation is to partition the image into regions with more or less homogeneous properties; but the processes which estimate these properties should be confined within individual regions. A cooperative, iterative approach to segmentation and property estimation is defined; the results of each process at a given iteration are used to adjust the other process at the next iteration. A linked pyramid structure provides a framework for this process iteration. This hierarchical structure ensures rapid convergence even with strictly local communication between pyramid nodes.
Isolation and characterization of amylase inhibitors, (glucose)ndeoxynojirimycin. (1986)

Eight amylase inhibitors were isolated from a transglucosylation mixture of 1-deoxynojirimycin, soluble starch and bacterial saccharifying amylase. The inhibitors were found to be a series of compounds and were designated as (glucose)n • 1-deoxynojirimycin, from the results of constituent and reducing end analyses (n-1 to 8). The linkage between glucoses was determined to be α-1, 4 by the permenthylation or β-amylase digestion method. The glucose-1-deoxynojirimycin linkage was determined to be α-1, 4 by 1H and 13C-NMR spectroscopy. The inhibitors inhibited various amylases depending on the number of glucose residues. The size of the active site (subsite) of an amylase might influence its susceptibility to the inhibitors.
Low Impact Methanol Production from Sulfur Rich Coal Gasification (2017)

In economy nowadays, methanol is already a key compound widely employed as building block for producing intermediates or synthetic hydrocarbons, solvent, energy storage medium, and fuel. In recent times, methanol has been employed in a number of innovative applications. It is a clean and sustainable energy resource that can be produced starting from different sources traditional or renewable: natural gas, coal, biomass, landfill gas and power plant/industrial emissions. In this work is proposed an innovative low impact process for methanol production starting from coal gasification. The most important features, instead the traditional ones, are the lower emissions of CO2 (about 2.5%) and the surplus production of methanol (about 1.7%) without any addiction of primary sources. Moreover, it is demonstrated that a coal charges with a high sulfur content means a higher reduction of CO2 emissions. The key idea is the application of AG2STM technology that is a completely new effective route of processing acid gases: H2S and CO2 are converted into syngas (CO and H2) by means of a regenerative thermal reactor.
GaAs metal-semiconductor field-effect transistor with extremely low resistance nonalloyed ohmic contacts using an InAs/GaAs superlattice (1989)

GaAs metal-semiconductor field-effect transistors (MESFETs) with extremely low resistance nonalloyed ohmic contacts have been demonstrated. The contact structure consists of an n+-InAs/GaAs strained-layer superlattice and an InAs cap layer. Contact resistances as low as 0.036 Ω mm have been measured. These results represent the smallest figures reported to date for GaAs field-effect transistors. Nonalloyed MESFETs with 1 μm gate lengths had transconductances of about 210 mS/mm.
Antibody-dependent cellular cytotoxicity against HIV-coated target cells by peripheral blood monocytes from HIV seropositive asymptomatic patients. (1990)

Cytotoxic effector cells like cytotoxic T cells, NK cells, monocytes/macrophages, and neutrophils can lyse directly HIV-infected or HIV-coated cells in the absence or presence of anti-HIV antibodies. Therefore, these cytotoxic mechanisms can be invoked either in the control of HIV infection at early stages of the disease or in the generalized immunosuppression observed at later stages of the disease. The relationship between anti-HIV effector mechanisms and disease, however, remains elusive. The present study investigates in HIV+ seropositive asymptomatic patients peripheral blood monocytes (PBM)-mediated antibody dependent cellular cytotoxicity (ADCC) against HIV-coated target cells in the presence of heterologous or autologous anti-HIV serum. To test for specific ADCC against HIV Ag, a T4+ CEM.TR line resistant to TNF and macrophage-mediated cytotoxicity was selected in vitro. ADCC was performed in an 18-h 51Cr-release assay using CEM.TR cells coated with inactivated HIV. Unlike PBM from normal controls, significant ADCC was observed by PBM from HIV+ seropositive patients in the presence of pooled HIV+ antiserum. The ADCC activity was specific for HIV and was dependent on the E:T ratio and the antiserum dilution used. Upon activation of PBM with rIFN-gamma, both normal and HIV+ PBM-mediated ADCC against HIV-coated CEM.TR. Furthermore, ADCC activity by PBM from HIV+ seropositive patients in the presence of their autologous serum was examined. Significant ADCC activity was observed and was dependent on the E:T ratio and serum dilution used. The findings demonstrating anti-HIV ADCC activity by PBM from HIV+ seropositive individuals and their autologous sera support the notion that monocyte-mediated ADCC may be operative in vivo.
Effects of simultaneous viewing and vaporization of plaques using the steerable, laser‐heated metal cap in the atherosclerotic monkey model (1987)

A steerable, fiberoptic catheter coupled to a laser light guide tipped with a metal cap was used. Four monkeys fed an atherogenic diet for 7-8 years were angiographed and were found to have extensive mural plaque in the iliac arteries. Plaque sites in these monkeys were vaporized using the laser-heated metal cap. Energies of 1.5-9 Joules were employed. Application of the energy was tangential of perpendicular to the plaque. Lased sites were examined histologically at 24 hr or at 3 months after treatment. No effect was seen at 1.5 Joules. Three to six Joules tangentially produced a superficial lesion that extended into the tunica intima. Six Joules perpendicularly produced a burn into the tunica adventitia, with damage to the vasavasorum. Nine Joules tangentially produced a burn into the tunica media. Three months after treatment, this lased site showed no stenosis or aneurysm formation.
Multiphoton Fabrication. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Use of recombinant human granulocyte-macrophage colony-stimulating factor in graft failure after bone marrow transplantation (1990)

The effect of recombinant human granulocyte-macrophage colony- stimulating factor (rhGM-CSF) was evaluated in 37 patients with marrow graft failure after allogeneic (n = 15), autologous (n = 21), or syngeneic (n = 1) bone marrow transplantation. rhGM-CSF was administered by 2-hour infusion at doses between 60 and 1,000 micrograms/m2/d for 14 or 21 days. At doses of less than 500 micrograms/m2, rhGM-CSF was well-tolerated and did not exacerbate graft- versus-host disease in allogeneic transplant recipients. No patient with myelogenous leukemia relapsed while receiving rhGM-CSF. Twenty-one patients reached an absolute neutrophil count (ANC) greater than or equal to 0.5 x 10(9)/L within 2 weeks of starting therapy while 16 did not. None of seven patients who received chemically purged autologous marrow grafts responded to rhGM-CSF. The survival rates of GM-CSF- treated patients were significantly better than those of a historical control group.
A Benzothiadiazole Extends Cut Carnation Flower Life1 (1973)

Abstract Immersion of cut carnation, Dianthus caryophyllus L. ‘Red Sim’ at the open, partially open or tight bud stage for 6-24 hours in 5-methyl-7-chloro-4-ethoxycarbonylmethoxy-2, 1, 3-benzothiadiazole (MCED) at 5 ppm in combination with 8-hydroxyquinoline sulfate (8HQS) at 200 ppm and 1.5% sucrose increased flower life. The greatest increase occurred when flowers were immersed in the solution at the partially open and tight bud stages for 12 to 24 hours.
Sol-gel derived vertical microcavity emitting at 525 nm (2004)

Fabrication of integrated active devices is being subject of intense research. In this paper, we present a vertical microcavity fabricated by the aerosol-gel process. It is composed of a half-wave Y/sub 2-x/Er/sub x/Ti/sub 2/O/sub 7/ (YETO) active layer sandwiched between two dielectric Bragg mirrors. These latters are elaborated by alternatively depositing SiO/sub 2/ and TiO/sub 2/quarter-wave layers. Transmission and up-conversion emission spectra of the microcavity and emission spectrum of a single YETO layer is analysed.
Chronic Diarrhea and Bacteremia Caused by Campylobacter lari in a Neonate (1995)

Journal Article Chronic Diarrhea and Bacteremia Caused by Campylobacter lari in a Neonate Get access Cheng-Hsun Chiu, Cheng-Hsun Chiu Department of Pediatrics, Chang Gung Children's Hospital; and Department of Microbiology and Immunology, Chang Gung College of Medicine and Technology, Taoyuan, Taiwan Reprints or correspondence: Dr. Cheng-Hsun Chiu, Department of Pediatrics, Chang Gung Children's Hospital, 5, Fu-Shin Street, Kweishan 333, Taoyuan, Taiwan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Chii-Yuh Kuo, Chii-Yuh Kuo Department of Pediatrics, Chang Gung Children's Hospital; and Department of Microbiology and Immunology, Chang Gung College of Medicine and Technology, Taoyuan, Taiwan Search for other works by this author on: Oxford Academic PubMed Google Scholar Jonathan T. Ou Jonathan T. Ou Department of Pediatrics, Chang Gung Children's Hospital; and Department of Microbiology and Immunology, Chang Gung College of Medicine and Technology, Taoyuan, Taiwan Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, Volume 21, Issue 3, September 1995, Pages 700–701, https://doi.org/10.1093/clinids/21.3.700 Published: 01 September 1995
Thyroid and glucocorticoid hormones synergistically control growth hormone mRNA in cultured GH1 cells. (1978)

We have previously demonstrated that thyroid hormone controls growth hormone synthesis in GH1 cells and that the induction of the growth hormone response by glucocorticoid appears to be highly dependent on thyroid hormone action. Thyroid hormone induces growth hormone synthesis approximately 5- to 20-fold and cortisol increases this response 2- to 6-fold further. Long-term kinetics of the growth hormone response show that, without added thyroid hormone, cortisol can induce a small-growth hormone response after 48 hr of incubation. Sodium dodecyl sulfate/polyacrylamide gel electrophoresis of proteins synthesized in intact cells demonstrates that the cortisol enhancement of growth hormone synthesis in cells incubated with thyroid hormone is a relatively selective process. Quantitation of growth hormone mRNA levels by cell-free protein synthesis demonstrates that the regulation of growth hormone synthesis by thyroid and glucocorticoid hormones is explained by a synergistic pretranslational control mechanism, presumably at the level of the growth hormone gene.
Van Der Waals Surface Areas and Volumes of Fullerenes (1994)

We present calculations of van der Waals (vdW) surface area (S) and volume (V) for a variety of carbon fullerence molecules ranging from C-20 to C-240. Also reported are calculations of the inner vdW cavity volume and of the nuclear framework surface area and volume (S-n and V-n). The vdW radius r of a carbon atom is not uniquely defined. so our S and V values are generated for r(min) = 1.47 Angstrom and r(max) = 1.76 Angstrom. Calculation of S and V at intermediate r values indicates that simple linear interpolation between the (r(min), r(max)) limits is accurate to within 1%. We also find that Sn can be calculated to within 1% of the actual value for C-60 and larger fullerenes by assuming all bonds have the C-C bond length of graphite (1.415 Angstrom).
Risk of Postoperative Cerebrospinal Fluid Leak in Reused Nasoseptal Flaps (2017)

Introduction: The nasoseptal flap takedown technique is an attractive option for reoperations or staged endoscopic endonasal skull base surgeries. However, it is often used in the setting of larger defects, and may suffer from retraction and less pliability of the flap, which may lead to a higher incidence of postoperative CSF leaks.
Chip electrospray mass spectrometry for carbohydrate analysis (2005)

Currently two types of chip systems are used in conjunction with MS: out-of-plane devices, where hundreds of nozzles, nanospray emitters are integrated onto a single silicon substrate from which electrospray is established perpendicular to the substrate, and planar microchips, embedding a microchannel at the end of which electrospray is generated in-plane, on the edge of the microchip. In the last two years, carbohydrate research greatly benefited from the introduction and implementation of the chip-based MS. In two laboratories the advantages of the chip electrospray in terms of ionization efficiency, sensitivity, reproducibility, quality of data in combination with high mass accuracy, and resolution of detection were systematically explored for several carbohydrate classes: O- and N-glycopeptides, oligosaccharides, gangliosides and glycoprotein-derived O- and N-glycans, and glycopeptides. The current state-of-the-art in interfacing the chip electrospray devices to high-performance MS for carbohydrate analysis, and the particular requirements for method optimization in both positive and negative ion modes are reviewed here. The recent applications of these miniaturized devices and their general potential for glycomic-based surveys are highlighted.
Bio-chemical sensor based on imperfected plastic optical fiber (2007)

In this paper we report results for an intrinsic evanescent field sensor based on not-regular plastic optical fiber with polymer film containing Malachite Green MG<sup>+</sup>([PhC(C<sub>6</sub>H<sub>4</sub>NMe<sub>2</sub>)<sub>3</sub>]<sup>+</sup>) as an absorption reagent, which coats the fiber's imperfected area. A theoretical model was developed which shows that changes of light in such structure result from the attenuation of light in the strait and bent imperfected fiber. In this model, the imperfected area with malachite green polymer film is replaced by a uniform layer with a complex refractive index. The changes in color and absorption characteristics of the polymer film depend on the acidic and basic environmental properties in the sensing area. Additional increase of the evanescent field interaction can be achieved by decrease the bending radius of the fiber with the coated imperfection area at the middle of the bent fiber. An imperfected plastic optical fiber with Malachite Green coating has been presented for the detection of ammonia vapor. The initial results show that depending on the sensing application demands, it is possible to design a high sensitive sensor with a relatively long response time, while when the demands require fast response times the sensor with less sensitivity can be used. In addition, the sensors' sensitivity can be calibrated in real-time by changing the bending radius.
Classification Techniques for Quantum-Limited and Classical-Intensity Images (1989)

Thesis (Ph. D.)--University of Rochester. College of Engineering and Applied Science. Institute of Optics, 1990.