gebhart/patrepeval huggingface dataset:
Laminar Analysis of the Number of Neurons, Astrocytes, Oligodendrocytes and Microglia in the Visual Cortex (Area 17) of 3-Month-Old Rhesus Monkeys Fed a Human Infant Soy-Protein Formula with or without Taurine Supplementation from Birth (1991)

The effect of taurine addition to a commercial (taurine-free) soy-protein formula on the development of the visual cortex has been examined in 3-month-old rhesus monkeys. The thickness, number of neurons, astrocytes, oligodendrocytes and microglia have been measured in the different laminae. There were no significant differences in cortical thickness, total number of neurons, astrocytes, oligodendrocytes, or microglia between the groups, but there were some significant differences in some laminae as well as some qualitative differences. The numerical density of neurons in layers IV-C alpha and V-2 was significantly greater in the taurine-supplemented monkeys than in those fed the taurine-free formula; the numerical density of astrocytes in layer IV-A was significantly greater and in layer IV-C alpha was significantly smaller in the taurine-supplemented monkeys than in those fed the taurine-free formula. A number of other measurements in the two groups approached significance. These differences indicate that there are developmental disadvantages in the visual cortex of rhesus monkeys raised on a taurine-free human infant formula in addition to those previously reported.
Synthesis of specifically deuterated adenosine A<sub>1</sub> antagonist: BG9928 (2007)

Abstract BG9928, a high affinity adenosine A 1 antagonist, is currently in Phase II clinical trials for the treatment of congestive heart failure. A deuterium‐labeled version of the molecule was synthesized and used as a standard for in vivo pharmacokinetic and in vitro metabolism studies. The labeled form of 3‐[4‐(2,6‐dioxo‐1,3‐dipropyl‐2,3,6,7‐tetrahydro‐1 H ‐purin‐8‐yl)‐bicyclo[2.2.2]oct‐1‐yl]‐propionic acid (BG9928) was obtained in a convergent manner by joining two major building blocks: the specifically labeled heterocycle 5,6‐diamino‐1,3‐dipropyl‐1 H ‐pyrimidine‐2,4‐dione ( 4 ) and the hemiester 4‐(2‐methoxycarbonyl‐ethyl)‐bicyclo[2.2.2]octane‐1‐carboxylic acid ( 10 ). Copyright © 2007 John Wiley & Sons, Ltd.
Immunodeficiency in Down's syndrome: T-lymphocyte subset imbalance in trisomic children. (1978)

In fourteen children with Down's syndrome the percentage of circulating T-cells forming rosettes with sheep erythrocytes, either in the presence or in the absence of foetal calf serum, was significantly lower than in appropriately matched controls. In contrast the percentage of T-cells forming rosettes with human erythrocytes was significantly higher in children with Down's syndrome than in controls. These data support the hypothesis that a defective T-cell maturation is an early integral feature of Down's syndrome.
Phase Transitions in Mixed Monolayers of Sodium Dodecyl Sulfate and Dodecanol at the Air/Water Interface (1998)

A two-dimensional phase transition has been studied in a mixed monolayer of sodium dodecyl sulfate (SDS) and dodecanol at the air/water interface by sum-frequency spectroscopy and ellipsometry. At low temperatures, a monolayer at the surface of a 6 mM solution containing 99.9% SDS and 0.1% dodecanol (w/w) is conformationally ordered and has a surface coverage comparable to that of a monolayer of pure dodecanol at the same temperature. At 16 °C there is a first-order transition to a phase that is less dense and more conformationally disordered. The high-temperature monolayer phase is more disordered than the corresponding liquid phase in pure dodecanol. The solid phase contains equimolar amounts of SDS and dodecanol while the liquid phase contains SDS and dodecanol in a ratio of approximately 3:2. The change in composition of the mixed monolayer can be understood qualitatively by a reduction in the interaction parameter in the monolayer at the phase transition.
Nonlinear plasmonics in a gallium/aluminium nano-composite (2006)

We report the discovery of a highly nonlinear material structure that supports surface plasmon-polariton (SPP) waves. It is generally perceived that nonlinear SPP propagation regimes are difficult to achieve because SPP's are localized between two low-nonlinearity media - a highly transparent dielectric and a metal.<br/><br/>Here we show that a structural transformation in the metal provides a strong, reliable nonlinear response mechanism that affects and enables 'active' control of SPP propagation.<br/><br/>The material structure is a self-assembled nanoscale composite comprising a polycrystalline aluminium film (on a silica substrate) wherein the grain boundaries between aluminium domains and the aluminium/silica interface are infiltrated with nanolayers of gallium. A substantial change in this material's electronic and optical properties is provided by a reversible excitation-induced shift in the equilibrium between gallium's solid and liquid phases, while the framework of microscopic aluminium domains maintains the stability of the structure.<br/><br/>It is well suited to nonlinear switching contrast: the SPP decay length in liquid gallium (5-20 plasmonic applications such as the active control of SPP propagation because the excitation-induced transition in gallium is surface-driven and provides very good µm at visible and near-IR wavelengths) is approximately ten times longer than in solid gallium. The formation of the gallium/aluminium composite has been investigated using Electron Backscatter Diffraction and its ability to control SPP waves with sub-ns response and sub-µs relaxation times demonstrated in experiments based on the Otto configuration for SPP wave excitation, and on metal/dielectric micro-gratings (prepared by photolithography) designed to couple light to/from SPP's.
Stability and performance robustness of manipulators (1985)

A method for the synthesis of robust controllers of manipulators is described. The emphasis is on the design of control systems in the presence of uncertainties. The sources of uncertainty are parameter errors as well as unmodeled dynamics and non-linear effects. The closed-loop system is to remain stable and performance robustness specifications are to be achieved despite model uncertainties. Stability and performance robustness measures are derived which are functions of frequency. Given a linear model for the manipulator, and a bound on model error, these measures evaluate various control system designs and enable the designer to determine (for a given design) whether stability and performance robustness specifications can be guaranteed in the presence of model uncertainties. The results are applied to a 2 degree-of-freedom spatial manipulator.
Design of a Low Gravity Simulator for Performing Non-Equilibrium Investigations near the Lambda Transition of ^4He (1993)

A design is presented of a low gravity simulator where a magnetic field gradient is employed to oppose the hydrostatic pressure effects of gravity. It appears feasible to reduce the effective gravity environment of the helium in the cell by about two orders of magnitude. The corresponding shift in transition temperature with vertical height would be reduced to 12.7 nK/cm. Methods for instrumenting the simulator to perform high resolution investigations of non-equilibrium phenomena near the lambda point are presented. The advantages of using a low gravity simulator in searching for the predicted change in character of the superfluid transition from continuous to first order in the presence of a heat current are also discussed.
Chloromethyl Methyl Sulfone by Oxidation of Chloromethyl Methyl Sulfide. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Potentiometric Response Properties of Sensor Membranes Based on Cobalt Phthalocyanine Conjugate-Polymer in Nonaqueous Solutions (1996)

Abstract Some experiments are carried out in order to clarify the reason why the electrode prepared by coating a platinum disk with a non-plasticized membrane of polyacrylaminde polymer (PAA) coupled to cobalt phthalocyanine (CoPc) shows such a Nernstian response and a special selectivity for fluoride and cyanide ions in acetonitrile (AN). Special interactions between the ions and CoPc are observed spectrophotometrically. A complexing ability of the CoPc with only fluoride and cyanide ions works to respond in a Nernstian way for the ions at the electrode. Since the electrode shows quite poor response to chloride and bromide ions it can be understood that an ion exchange reaction of the ions in the solution at CoPc does not function to the response of the electrode. Furthermore, the PAA matrix of the membrane is found to produce the electrochemical masking effect on chloride and bromide ions. The PAA–CoPc electrode is confirmed as available for use of determining the solubility product constant of sodium fluoride in AN.
Indium‐Mediated Propargylation of Imines and Imine Oxides in Aqueous Media: Propargylation of >C=N‐ Centers. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Theoretical of and Experimental Investigation Finline Discontinuities (1985)

The dominant and the first-five higher order modes in a unilateral finline are precisely described from a thorough spectral-domain approach. Then, using the modal analysis, coupling coefficients between eigenmodes at a discontinuity that have to be introduced into the scattering matrix formulation are directly computed in the spectral-domain, and, consequently, the equivalent circuit parameters of the discontinuity are determined. Finafly, finline discontinuities often used for impedance transformation are investigated and a good agreement between theoretical and experimental results is reported.
Evidence of direct smooth muscle relaxant effects of the fibrate gemfibrozil (2010)

Fibrates are commonly employed to treat abnormal lipid metabolism via their unique ability to stimulate peroxisome proliferator-activated receptor alpha (PPARalpha). Interestingly, they also decrease systemic arterial pressure, despite recent evidence that PPAR alpha may contribute to expression of renin and related hypertension. Yet, mechanisms responsible for their potential antihypertensive activity remain unresolved. Rapid decreases in arterial pressure following bolus intravenous injections of bezafibrate strongly suggest they may relax arterial smooth muscle directly. But since bezafibrate is highly susceptible to photodegradation in aqueous media, it has never been critically tested for this possibility in vitro with isolated arterial smooth muscle preparations. Accordingly, we tested gemfibrozil which is resistant to photodegradation. We examined it over a therapeutically-relevant range (50-400 microM) for both acute and delayed relaxant effects on contractions of the isolated rat tail artery; contractions induced by either depolarizing its smooth muscle cell membranes with high potassium or stimulating its membrane-bound receptors with norepinephrine and arginine-vasopressin. We also examined these same gemfibrozil levels for effects on spontaneously-occurring phasic rhythmic contractile activity, typically not seen in arteries under in vitro conditions but commonly exhibited by smooth muscle of uterus, duodenum and bladder. We found that gemfibrozil significantly relaxed all induced forms of contraction in the rat tail artery, acutely at the higher test levels and after a delay of a few hours at the lower test levels. The highest test level of gemfibrozil (400 microM) also completely abolished spontaneously-occurring contractile activity of the isolated uterus and duodenum and markedly suppressed it in the bladder. This is the first evidence that a fibrate drug can directly relax smooth muscle contractions, either induced by various contractile agents or spontaneously-occurring. These findings are particularly relevant to both the recently renewed concern over the impact of fibrates on hypertension and a new understanding of their gastrointestinal side effects.
Yeast checkpoint controls and relevance to cancer. (1997)

Checkpoint controls arrest cells with defects in DNA replication or DNA damage. For several reasons, checkpoint controls may be relevant to ontogeny and treatment of cancer. Firstly, mutations in two human genes, TP53 and ATM, give rise to cellular defects in cell cycle checkpoints and are associated with cancer. Secondly, although checkpoint defects potentially render the cell damage sensitive, they may do so only in combination with other defects in the cell's response to damage. Therefore, manipulation of checkpoint defects, requiring a description of normal and mutant pathways, will be required for this type of therapeutic approach. Those pathways are being described in yeast cells. In budding yeast, the study of checkpoint genes has led to the view that these genes have many roles in the cellular responses to DNA damage, including roles in arrest in multiple stages of cell cycle, in transcriptional induction of repair genes, in DNA repair itself and additionally some undefined role in DNA replication. The checkpoint pathways and proteins that carry out these responses may consist of sensor proteins that detect damage, signaller proteins that transduce an inhibitory signal and target proteins that are altered to arrest cell division (or cause other changes in cell behaviour). Yeast genes that may act at each step have been identified, leading to a working model of checkpoint pathways. An initial step in the pathway may involve the processing of damage to an intermediate that signals arrest and acts in DNA repair. Human checkpoint pathways may have defects in processing damage as well.
Boris Godunov and Other Dramatic Works (1831)

Boris Godunov A Scene from Faust The Miserly Knight Mozart and Salieri The Stone Guest A Feast in Time of Plague Rusalka (The Water-Nymph)
Design and Development of a Wireless Remote Point-of-Care Patient Monitoring System (2007)

Remote patient monitoring is an alternative to regular home check-ups of patients with certain special medical conditions or the elderly who are unable to regularly visit a healthcare facility. This technology reduces the number of home visits which are now only required when special attention is needed. This paper presents the design and development of a remote point-of-care patient monitoring system which allows the patient to be monitored remotely while remaining in the comfort of their home. The system described here allows wireless data acquisition from eight patient-worn sensors. The number and type of sensors are configurable according to the subject's specific condition. The system uses the standard Bluetooth <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> technology for communication with a home based monitor which in turn relays this data to the remote healthcare facility using the internet. This data can be used for real-time evaluation of the patient's conditions as well as data logging for later analysis. Since this is a configurable system, a few selected sensors are connected to demonstrate the concept of remote patient monitoring; these include Electrocardiogram (ECG), Electroencephalogram (EEG), Airflow, respiration, patient movement and body temperature. The results obtained from these tests are also presented in this paper.
Internal and External Consistency of Doppler, Satellite-Triangulation, and Terrestrial Networks (1974)

Three sample networks in Atlantic Canada are compared: one eight-station Doppler satellite network, one triangle of the North American densification of the USNGS world satellite triangulation network, and one terrestrial triangulation network. The method used to compute the Doppler network is described. The internal consistency of each network is assessed through analysis of covariance matrices. The externa! consistency between the Doppler and satellite triangulation, and between the Doppler and terrestrial networks is assessed by comparing the interstation distances in one network with the appropriate confidence regions in the other.
Effects of the EDF length and oscillation reflectivity on theoutput powerof a 1.55 pm ring fiber laser system (1998)

The effects of varying the Erbium doped fiber (EDF) length and the loop-back
reflectivity of an all fiber ring laser system are presented. Two characteristics of the
output power, namely the lasing threshold and the maximum power are analyzed. The
reflectivity is taken as the percentage of the lasing signal that is fed (or reflected)
back into the loop. The maximum output power refers to the power obtained at
maximum pump power available, 115 mW. This therefore does not represent the
actual maximum output power obtainable with the EDFL system which should be
higher. For a particular system, there is an optimum length of EDF that gives the
lowest lasing threshold. Smaller reflectivity is found to give a higher maximum output
power but at the expense of a higher lasing threshold
Pyridylmethylindanol Derivatives. Reductive Cyclization to Octahydroindenoindolizine<sup>1</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyridylmethylindanol Derivatives. Reductive Cyclization to Octahydroindenoindolizine1Joseph Sam, James N. Plampin, and Dru W. AlwaniCite this: J. Org. Chem. 1962, 27, 12, 4543–4546Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/jo01059a102https://doi.org/10.1021/jo01059a102research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A high-sensitivity CMOS image sensor with gain-adaptive column amplifiers (2005)

A high-sensitivity CMOS image sensor using gain-adaptive column amplifiers is presented and tested. The use of high gain for the column amplifier reduces input-referred random noise, and when coupled with a column-based digital noise cancellation technique, also reduces fixed pattern noise. An experimental application of the circuit using 0.25-/spl mu/m CMOS technology with pinned photodiodes gave an rms random noise of 263 /spl mu/V and an rms fixed pattern noise of 50 /spl mu/V.
Mapping of 23‐S rRNA at the Ribosomal Peptidyl‐Transferase Center by Photo‐Affinity Labeling (1977)

Photo-sensitive peptidyl-tRNA's were used to scan the environment of the peptidyl-transferase center of the ribosome. The specificity of the previously described labeling in the 18-S fragment of 23-S rRNA by Boc-Phe(N3)-Phe-tRNA (4-azido-N-t-butoxycarbonyl-phenylalanyl-phenylalanyl-tRNA) was demonstrated by the ability of the covalently anchored molecule to serve as donor substrate in peptide bond formation. Labeling patterns were also obtained with Boc-Phe(N3)-Phe-Phe-tRNA bound at the acceptor site and with Boc-Phe(N3)-(Gly)n-Phe-tRNA (n = 2,4). The results indicate that subsequences within the 18-S fragment of 23-S rRNA are located close to the acceptor site as well as along the path where the peptide moiety adheres to the ribosome. Identification of the labeled sequences is expected to shed light on the spatial arrangement as well as functional role of rRNA in the peptidyl transferase center.
Incorporating Correlations among Gene Ontology Terms into Predicting Protein Functions (2011)

The authors describe a new strategy that has better prediction performance than previous methods, which gives additional insights about the importance of the dependence between functional terms when inferring protein function.
Effects of Norethandrolone on the Transport and Peripheral Metabolism of Thyroxine in Patients Lacking Thyroxine-Binding Globulin (1971)

Studies of the effect of norethandrolone on the transport and peripheral metabolism of thyroxine were carried out in four patients lacking thyroxine-binding globulin. Before norethandrolone administration, values for serum protein-bound iodine (PBI) were decreased (1.8 +/-0.5 mug/100 ml) and the proportion of free thyroxine increased (0.036 +/-0.008%). As a result, values for the absolute concentration of free thyroxine iodine were at the lower end of the normal range (0.63 +/-0.12 mmug/100 ml). During the control thyroxine-turnover study, the thyroxine distribution space was strikingly increased (18.2 +/-7.9 liters) and the fractional rate of thyroxine turnover moderately increased (17.1 +/-11.3%/day), as compared to the expected mean values for normal subjects. Therefore, calculated values for the daily rate of thyroxine clearance were increased even more, ranging between 255 and 500% of normal values. However, owing to the low PBI in these patients, the daily disposal of thyroxine iodine was similar to that expected in normals on the basis of age and weight. During the administration of norethandrolone, the thyroxine-binding capacity of the thyroxine-binding prealbumin increased strikingly in all patients, values averaging 162% of those found during the control period. This increase was associated with a highly significant increase in PBI (133% of control values) and a small but significant decrease in the proportion of free thyroxine, resulting in no significant change in the absolute concentration of free thyroxine iodine. In all four patients, administration of norethandrolone was associated with a pronounced decrease in the thyroxine distribution space to values which averaged 69% of those found during the control period. Values for the fractional rate of thyroxine turnover increased slightly. As a result, thyroxine-clearance rate decreased in all patients. Owing to the reciprocal changes in clearance rate and PBI, no significant change in total daily thyroxine disposal was observed. The present studies reveal that when the thyroxine-binding prealbumin is increased in patients lacking thyroxine-binding globulin, several indices of peripheral thyroxine transport and metabolism are altered. However, these changes were small, even in the absence of thyroxine-binding globulin. It is suggested, therefore, that the effect of changes in thyroxine-binding prealbumin would be even smaller in individuals in whom thyroxine-binding globulin is present.
Evaluating the yield of gastrointestinal testing in pediatric patients in aerodigestive clinic (2018)

Children with feeding difficulty, TEF/EA, and asthma were the mostly likely to have a histologic abnormality on EGD or an abnormal pH-MII. The majority of children were previously prescribed acid suppression medication and had a referring diagnosis of gastroesophageal reflux disease but were subsequently found to have normal evaluation. Prospective studies are needed to optimize care of this population.