gebhart/patrepeval huggingface dataset:
Erratum for “Heritabilities and Correlations of Fusarium Ear Rot Resistance and Fumonisin Contamination Resistance in Two Maize Populations” (2006)

In volume 46, issue 1, p. 353-361, the estimates of heritability for fumonisin concentration and Fusarium ear rot in the NC300 3 B104 recombinant inbred population were computed incorrectly. The corrected estimates of heritability on an entry mean basis are 0.88 (SE 5 0.03) for fumonisin concentration and 0.86 (SE 5 0.03) for ear rot. The corrected estimates of heritability on a plot basis are 0.58 (SE 5 0.06) for fumonisin concentration and 0.55 (SE 5 0.07) for ear rot. The corrected estimate of heritability on an individual plant basis for ear rot is 0.22 (SE 5 0.03). The corrected estimate of the relative efficiency of indirect selection is 0.85. All of the corrected parameter estimates are higher than the original estimates reported, and the changes do not affect our conclusions.
Detection of Hepatitis B Virus DNA in Tissues of Hepatocellular Carcinomas Related to Hepatitis C Virus Which Are Negative for Hepatitis B Virus Surface Antigen (1999)

HCC tissues from patients seronegative for HBsAg and seropositive for HCVAb contain HBV DNA less frequently than has generally been claimed.
ChemInform Abstract: 2‐Hydroxy‐2H‐1,4‐benzoxazin‐3‐one from Scoparia dulcis (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sequence Requirements for Binding of Src Family Tyrosine Kinases to Activated Growth Factor Receptors (1995)

Activation of growth factor receptor protein tyrosine kinases frequently results in the binding of numerous proteins to their tyrosine-phosphorylated cytoplasmic domains. These interactions involve the SH2 domains of the binding proteins and phosphorylated tyrosines on the receptor molecules, with the specificity of interaction dictated by the amino acid composition surrounding the phosphorylated tyrosine. In the case of the platelet-derived growth factor (PDGF) receptor, the major binding site for Src family tyrosine kinases is in the juxtamembrane domain and includes tyrosine 579 (Mori, S., Rönnstrand, L., Yokote, K., Engström, A., Courtneidge, S. A., Claesson-Welsh, L., and Heldin, C-H. (1993) EMBO J. 12, 2257-2264). To analyze in more detail which amino acids surrounding the phosphorylated tyrosine at position 579 were important for high affinity interaction with Src family kinases, we synthesized a series of phosphopeptides corresponding to this binding site in which single amino acids were individually changed and tested their ability to compete with the PDGF receptor for binding of Fyn. We found that not only the three residues carboxyl-terminal to the phosphorylated tyrosine were important but that also residues at positions -1 and +4 relative to the tyrosine were required. Phosphorylation of both tyrosines 579 and 581 significantly increased competition efficiency. The activated colony stimulating factor-1 (CSF-1) receptor, which is known to associate with Src family kinases, has a sequence in its juxtamembrane region similar to that surrounding Tyr-579 of the PDGF receptor, and a phosphopeptide modeled on this sequence competed the association of Fyn with the receptor in vitro. Furthermore, mutational analysis demonstrated that these sequences were required for the efficient association of Src family kinases with the activated CSF-1 receptor in vivo. Phosphopeptides corresponding to the Src family binding sites of both PDGF and CSF-1 receptors activated Src kinase activity in vitro. These observations support a model in which the enzymatic activity of Src family tyrosine kinases is controlled by intra- and intermolecular interactions of tyrosine-phosphorylated peptides with the SH2 domain of the kinases.
1-Indancarboxylic acids. III. Chemical modifications of antiinflammatory 4-aroyl-1-indancarboxylic acids. (1978)

For elucidating the receptor site of antiinflammatory arylacetic acids, some modifications were made on 4-aroyl-1-indancarboxylic acids (Ia-d) which have potent antiinflammatory activities. Modifications were introduced on the characteristic parts of I and 1-methylated derivatives (VIII), tetralin analogs (XVIII) and benzyl analogs (XXX) of I were prepared. However, these compounds showed weaker activities than the parent compound I. The result suggests that 1-indancarboxylic acid is the pharmacologically effective derivative of arylacetic acid.
Design of a Minimal Polypeptide Unit for Bacteriochlorophyll Binding and Self-Assembly Based on Photosynthetic Bacterial Light-Harvesting Proteins (2006)

We introduce LH1beta24, a minimal 24 amino acid polypeptide that binds and assembles bacteriochlorophylls (BChls) in micelles of octyl beta-glucoside (OG) into complexes with spectral properties that resemble those of B820, a universal intermediate in the assembly of native purple bacterial light-harvesting complexes (LHs). LH1beta24 was designed by a survey of sequences and crystal structures of bacterial LH proteins from different organisms combined with currently available information from in vitro reconstitution studies and genetically modified LHs in vivo. We took as a template for the design sphbeta31, a truncated 31 amino acid analogue of the native beta-apoprotein from the core LH complex of Rhodobacter sphaeroides. This peptide self-assembles with BChls to form B820 and, upon cooling and lowering OG concentration, forms red-shifted B850 spectral species that are considered analogous to native LH complexes. We find that LH1beta24 self-assembles with BChl in OG to form homodimeric B820-type subunits comprising two LH1beta24 and two BChl molecules per subunit. We demonstrate, by modeling the structure using the highly homologous structure of LH2 from Rhodospirillum molischianum, that it has the minimal size for BChl binding. Additionally, we have compared the self-assembly of sphbeta31 and LH1beta24 with BChls and discovered that the association enthalpies and entropies of both species are similar to those measured for native LH1 from Rhodospirillum rubrum. However, sphbeta31 readily aggregates into intermediate higher oligomeric species and further to form B850 species; moreover, the assembly process of these oligomers is not reversible, and they are apparently large nonspecific BChl-peptide coaggregates rather than well-defined nativelike LH complexes. Similar aggregates were observed during LH1beta24 assembly, but these were formed less readily and required lower temperatures than sphbeta31. In view of these results, we reevaluate previous in vitro reconstitution studies and propose alternative templates for new designs.
End-to-end delay satisfaction balancing routing (2005)

This paper presents QoS-based routing algorithms using the end-to-end delay satisfaction balancing concept. The algorithms are suitable for networks that do not use per-path reservation. A nonlinear optimization problem and a gradient-based solution are formulated for off-line computation of the optimal route configuration. An approximation of the optimization problem is developed for on-line distributed processing. Using the approximation, vector routing tables can be used to set-up paths for arriving calls. Performance of the proposed schemes is evaluated and compared with that of minimum-delay, minimum-hop, and min-interference routing algorithms. Results show that using an objective function based on delay satisfaction balancing enables the network to accommodate more users of varying end-to-end delay requirements.
Fluorine-19 Nuclear Magnetic Resonance Spectroscopic Study of Fluorophenylalanine- and Fluorotryptophan-Labeled Avian Egg White Lysozymes (1994)

We report the 470-MHz (11.7 T) 19F solution nuclear magnetic resonance (NMR) spectra of 2-, 3-, and 4-fluorophenylalanine incorporated into the egg white lysozymes (EC 3.2.1.17) of chicken, pheasant, and duck, as well as spectra of 4-fluorotryptophan incorporated into chicken, California valley quail, and Bob White quail and 5- and 6-fluorotryptophan-labeled chicken lysozyme. The 19F solution NMR spectrum of [4-F]Phe hen egg white lysozyme (HEWL) consists of three sharp resonances, which span a total chemical shift range of 4.8 ppm (at p2H = 6.1). For [3-F]Phe HEWL, the chemical shift range is much smaller, 1.0 ppm (at p2H = 5.9), due presumably to the occurrence of fast phenyl ring flips about the C beta-C gamma bond axis. For [2-F]Phe HEWL, six resonances are observed, spanning a chemical shift range of 7.4 ppm (at p2H = 5.8), due to slow C beta-C gamma ring flips, i.e., both ring-flip isomers appear to be "frozen in" because of steric hindrance. Rotation of the [2-F]Phe residues remains slow up to 55 degrees C (p2H = 4.7). With the [F]Trp-labeled proteins, we find a maximal 14.6-ppm shielding range for [4-F]Trp HEWL but only a 2.8- and 2.4-ppm range for [5- and 6-F]Trp HEWL, respectively, due presumably to increased solvent exposure in the latter cases. Guanidinium chloride denaturation causes loss of essentially all chemical shift nonequivalence, as does thermal denaturation. Spectra recorded as a function of pH show relatively small chemical shift changes (< 1.4 ppm) over the pH range of approximately 1.2-7.8.(ABSTRACT TRUNCATED AT 250 WORDS)
Quaternary GaInAsSb 2.0-2.5 micron back-illuminated focal plane array for blood glucose monitoring (2005)

A focal plane array detector sensitive from 2.0-2.5 μm and consisting of 32, 1.0 mm x 50 μm pixels, all functional, is demonstrated. Mean room-temperature R<sub>0</sub>A is found to be 1.0 Ωcm<sup>2</sup>, limited by sidewall leakage. The focal plane array is fabricated from an MBE-grown homojunction <i>p-i-n </i>GaInAsSb grown on an <i>n</i>-type GaSb substrate. Back-illumination geometry is compared to front-illumination geometry and is found to be favorable, particularly the improved responsivity (1.3 A/W at 2.35 μm corresponding to 68% quantum efficiency) due to reflection of light off the metal contact. Further, back-illumination is the most convenient geometry for mounting the array onto a compact blood glucose sensor because both contacts can be mounted on one side, while detector illumination occurs on the other.
Isobaric Tagging-Based Quantification for Proteomic Analysis: A Comparative Study of Spared and Affected Muscles from mdx Mice at the Early Phase of Dystrophy (2013)

Duchenne muscular dystrophy (DMD) is the most common childhood myopathy, characterized by muscle loss and cardiorespiratory failure. While the genetic basis of DMD is well established, secondary mechanisms associated with dystrophic pathophysiology are not fully clarified yet. In order to obtain new insights into the molecular mechanisms of muscle dystrophy during earlier stages of the disease, we performed a comparative proteomic profile of the spared extraocular muscles (EOM) vs. affected diaphragm from the mdx mice, using a label based shotgun proteomic approach. Out of the 857 identified proteins, 42 to 62 proteins had differential abundance of peptide ions. The calcium-handling proteins sarcalumenin and calsequestrin-1 were increased in control EOM compared with control DIA, reinforcing the view that constitutional properties of EOM are important for their protection against myonecrosis. The finding that galectin-1 (muscle regeneration), annexin A1 (anti-inflammatory) and HSP 47 (fibrosis) were increased in dystrophic diaphragm provides novel insights into the mechanisms through which mdx affected muscles are able to counteract dystrophy, during the early stage of the disease. Overall, the shotgun technique proved to be suitable to perform quantitative comparisons between distinct dystrophic muscles and allowed the suggestion of new potential biomarkers and drug targets for dystrophinopaties.
Hypermetabolism in Gaucher disease type I is not associated with altered thyroid hormone levels (2007)

Type I Gaucher disease (OMIM 231000) is an inherited storage disorder in which deficiency of the enzyme glucocerebrosidase (EC 32145) leads to accumulation of glucocerebroside in lysosomes of macrophages. These storage cells are present in liver, spleen and bone marrow resulting in hepatosplenomegaly, cytopenia and bone complications. Metabolic abnormalities in Gaucher patients include hypermetabolism, possibly caused by elevated levels of pro-inflammatory cytokines. Nonthyroidal illness (NTI) is a combination of changes in circulating thyroid hormone levels (decreased T(3), elevated rT(3), normal or mildly depressed TSH) present in different illnesses and might be an adaptation to protect the organism from harmful catabolic effects of hypermetabolism. The hypermetabolism and the elevated cytokine levels in Gaucher disease led us to hypothesize that the alterations in thyroid hormone levels as seen in NTI might also occur in Gaucher patients. We studied thyroid hormone levels before and during treatment in 22 adult type I Gaucher patients and resting energy expenditure (REE) and correlations with thyroid hormone levels in 12 patients. Baseline thyroid hormone levels were normal in the majority (17) of patients. No cases of nonthyroidal illness were detected. Baseline REE (kcal/kg per 24 h) was not correlated with circulating levels of T(3), rT(3) or fT(4). Treatment of Gaucher disease with enzyme replacement therapy for several years resulted in a decrease in circulating fT(4) levels. After several months of treatment most patients showed a decrease in REE. There was no correlation between the changes in REE and changes in fT(4) and T(3).
Sound detection and processing by teleost fishes: a critical review (1973)

The purpose of this critical review is to reevaluate the current experimental literature on fish audition based upon evaluation of structural, physiological and behavioral studies. The specific emphasis of the paper will be to (1) review the recent literature on the psychophysiology of hearing in fishes; (2) look at the subject of fish hearing from the standpoint of auditory mechanisms and their relationship to what is known about hearing in terrestrial vertebrates; and (3) emphasize some questions and areas of research which we feel require more investigation. Based on the data reviewed in the paper we have tentatively concluded that the teleost auditory system is well adapted as a temporal analyzer.
ACTIVATION OF PURIFIED GLUTAMIC—ASPARTIC APOTRANSAMINASE BY CRYSTALLINE PYRIDOXAMINE PHOSPHATE (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTACTIVATION OF PURIFIED GLUTAMIC—ASPARTIC APOTRANSAMINASE BY CRYSTALLINE PYRIDOXAMINE PHOSPHATEAlton Meister, Herbert A. Sober, and Elbert A. PetersonCite this: J. Am. Chem. Soc. 1952, 74, 9, 2385–2386Publication Date (Print):May 1, 1952Publication History Published online1 May 2002Published inissue 1 May 1952https://pubs.acs.org/doi/10.1021/ja01129a515https://doi.org/10.1021/ja01129a515research-articleACS PublicationsRequest reuse permissionsArticle Views21Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Honeycomb V<sub>2</sub>O<sub>5</sub>-CeO<sub>2</sub> Catalysts for H<sub>2</sub>S Abatement from Biogas by Direct Selective Oxidation to Sulfur at Low Temperature (2015)

Honeycomb V2O5/CeO2 structured catalysts were prepared for the H2S abatement from biogas by direct selective catalytic oxidation to sulphur and water at low temperature. Two commercial CeO2-based washcoats (Ecocat, Mel Chemicals) and a CeO2-based washcoat prepared in laboratory, used as a support for the active phase deposition, were deposited on a honeycomb monolith made of cordierite by dip coating procedure; after washcoat deposition and stabilization, the active phase (V2O5) was deposited by wet impregnation. The washcoats were characterized by X-Ray Diffraction, X-Ray Fluorescence (ED-XRF). The adhesion of the different washcoats on cordierite was investigated by ultrasonic vibration, by studying also the effect of the addition of the alumina binder on the catalyst properties. Different washcoats uncatalysed and catalysed with 2 wt% of V2O5 were tested in catalytic activity test at 200°C in order to compare the catalytic performance in terms of H2S abatement efficiency and resistance to the deactivation.
Innenrücktitelbild: Temperature‐Responsive Microgel Films as Reversible Carbon Dioxide Absorbents in Wet Environment (Angew. Chem. 10/2014) (2014)

Hydrogelfilme aus temperaturresponsiven und mit Amingruppen funktionalisierten Mikrogelpartikeln (GPs) können als Absorptionsmittel für CO2 verwendet werden, wie Y. Hoshino et al. in ihrer Zuschrift auf S. 2692 ff. berichten. Die Fähigkeit der GP-Filme, reversibel CO2 zu absorbieren, ist proportional zur Filmdicke, und ihre Kapazität übertrifft die eines monolithischen Gelfilms. Mit den GP-Filmen steht ein Material zur Verfügung, um CO2 energieeffizient aus sehr feuchten Abgasen abzutrennen.
ChemInform Abstract: Estimation of Bond Dissociation Gibbs Energies for Carbon‐Halogen Bonds in Anion Radicals of Some Aryl Halides and Substituted Benzyl Halides. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental demonstration of real-time DSP with FPGA-based optical transmitter (2008)

Digital signal processing has the potential to overcome cost and power challenges associated with optical links. The questions to address for short links (avoiding the requirement for temperature control, laser patterning, differential mode delay in multimode fibres, increasing capacity at low cost) are different to those for ultra-long telecom links (mainly chromatic and polarization mode dispersion, and fibre nonlinearity), but both may be solved through the use of DSP. We have completed the construction and begun experimental tests of the first FPGA-based optical transmitter, based on the Xilinx Virtex 4 field programmable gate array chip and D/A converters, operating at 21.4 GSa/s. This will allow DSP for both short optical interconnects and long-haul transmission systems to be experimentally investigated. This paper reviews recent development work on this transmitter and presents initial results.
WETTABILITY OF DRUG LOADED POLYMER MATRICES (1998)

ABSTRACT Drug release is to a large extent influenced by penetration of a dissolution liquid into a polymer matrix. If an aqueous medium does not wet a matrix, its penetration into the polymer bulk and the resulting drug extraction would be considerably hindered. It is therefore of extreme importance to study not only the physical state of drug loaded matrices but also their wettability and their penetration by an aqueous medium. In the present review paper we describe the results of two investigations, performed in our laboratory and having direct relevance to the medical and pharmaceutical fields: the estimation of wettabilities of polymer tablet formulations and of drug loaded polymer films. For tablet formulations it was clearly demonstrated that the use of high-viscosity polyols for contact angle and penetration experiments yielded incorruptible data which enabled to determine mean pore size of tablets from the Washburn equation. For drug-loaded cast films, as exemplified for SIBA (a cytostatic drug)-loaded ethylcellulose cast films, the choice of the solvent appeared to play a determinant role on the wettability and heterogeneity of films.
Atrial natriuretic factor: a protective role after acute renal ischaemia? A room for it in kidney transplantation? (1990)

Because of the deleterious effects of acute tubular necrosis (ATN) after kidney transplantation, the search for new and effective means of protecting the kidneys from ischemic or nephrotoxic injuries continues. The beneficial effects of hyperhydration with mannitol or furosemide infusions in renal allograft recipients have now been well documented. The recent discovery by De Bold and coworkers that hypovolemia (by atrial distension) induces the release of atrial natriuretic factor (ANF) suggests an important physiopathological, and perhaps therapeutic role for this natriuretic peptide in kidney transplantation. In addition to providing an overview of the current knowledge about ANF and its effects on both intact and ischemically injured kidneys, the physiological role of ANF in various situations, similar to those found in kidney transplantation, is analyzed. The effects of ANF on arachidonic acid metabolites and on the nephrotoxic side effects of cyclosporin are also reported. If the results of the preliminary experimental studies appear to be effective, further prospective clinical trials must be carried out to confirm them.
Hydration of <i>N</i>,<i>N</i>-Bis(2-ethylhexyl)hexanamide in Dodecane (1996)

Abstract The hydration and dimerization of N,N-bis(2-ethylhexyl) hexanamide (BEHHA) in dodecane were studied on the basis of the water distribution between aqueous solutions and dodecane. The data obtained at 298 K were analyzed as functions of the amide concentration in the organic phase and the water activity in the aqueous phase. When the amide was monomeric in the organic phase, only a monohydrate was formed. At high amide concentrations in the organic phase, dimerization of the monohydrate occurred and (BEHHA)2(H2O)2 was formed. No other dimer hydrates were found in the organic phase. The results were compared with those of tributyl phosphate (TBP). The stoichiometry between BEHHA and water was investigated from low to very high amide concentrations in dodecane. The change in the activity coefficient for an amide contained in an inert solvent at high concentrations was also examined.
Simulating clinical trials with and without intracranial <scp>EEG</scp> data (2016)

This study demonstrated using simulation that additional accuracy in seizure detection using chronically implanted icEEG improves statistical power of clinical trials. Newer invasive and noninvasive seizure detection devices may have the potential to provide greater statistical efficiency, accelerate drug discovery and lower trial costs.