gebhart/patrepeval huggingface dataset:
Marbles: a means of introducing students to scattering concepts (2007)

The purpose of this activity is to introduce students to concepts of short-range and long-range scattering, and engage them in using indirect measurements and probabilistic models. The activity uses simple and readily available apparatus, and can be adapted for use with secondary level students as well as those in general physics courses or teacher training programmes at the college level.
ChemInform Abstract: DYNAMICS OF RADICAL PAIR REACTIONS IN MICELLES (1985)

Abstract Durch gepulste Laser‐Photolyse der Ketone (I) bzw. (II), im Falle a) auch der Azoverbindung (III), werden die Radikale ′R′ (sec.‐Phenethyl, Diphenylmethyl, Cumyl) als Radikalpaare in micellarer Isooctan‐Lösung erzeugt.
Ferromagnetic resonance linewidth in thin films coupled to NiO (1998)

The out-of-plane angular dependence of the ferromagnetic resonance linewidth, ΔH, has been measured for thin magnetic films coupled to NiO and for uncoupled control films. In the control films, ΔH is described by nearly angle-independent damping parameters. In the NiO-coupled films, however, the damping was found to depend strongly on magnetization orientation, with linewidth values comparable to the control samples at normal orientation, but several times larger when the magnetization lies in plane. The additional linewidth in the NiO-coupled films follows the angular dependence of the number of nearly degenerate spin wave modes, in agreement with the predictions of a two-magnon scattering model of damping which incorporates a spin wave dispersion relation suitable for ultrathin films.
Platelet‐derived growth factor and dexamethasone combined with a collagen matrix induce regeneration of the periodontium in monkeys (1993)

Platelet-derived growth factor (PDGF) and the glucocorticoid dexamethasone combined with a collagen carrier matrix (CM) induced regeneration of the periodontium in monkeys. Regeneration was stringently defined as: (1) new cementum, (2) new supra-crestal bone extending coronally from the residual alveolar interdental septum and (3) functionally-oriented periodontal ligament fibers attaching new cementum to new bone. A single application of PDGF/dexamethasone/CM or CM was placed in debrided lesions of experimental periodontitis displaying 3-5 mm of attachment loss associated with horizontal and angular bony defects. Regeneration, judged histologically by these criteria and quantified by computer assisted histomorphometry after 4 weeks, was present only in PDGF/dexamethasone/CM treated lesions and not in those treated with CM or debridement alone. PDGF/dexamethasone/CM induced 5-fold more new cementum and ligament, and 7-fold more supra-crestal bone than control treatments. The presence of substantial amounts of regenerated periodontium including increased height of the alveolar bone; fill of vertically resorbed interdental alveolar septa in PDGF/dexamethasone/CM treated lesions suggests that this combination may provide a new therapeutic agent for the regeneration of lesions of periodontitis associated with horizontal as well as angular bony defects.
Neat Total Synthesis of Six Monoterpenic Alkaloids of the Actinidine Series. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stimulation of Ca2+ uptake and protein phosphorylation in tumor cells by fibronectin. (1981)

Suspensions derived from attached HeLa cells transported 45Ca2+ considerably faster than those derived from spinner cultures grown in liquid medium. Incubation of spinner cells with fibronectin or cold-insoluble globulin in the presence of 5% calf serum at 37 degrees C for 1 to 2 h greatly increased the rate of Ca2+ flux into the cells. Suspensions of cells transformed by Rous sarcoma virus transported Ca2+ much more slowly than cell suspensions of the parent strain of normal rat kidney. Incubation of the transformed cells or Ehrlich ascites tumor cells with fibronectin increased the rate of Ca2+ uptake, while no effect was seen on Ca2+ transport by this treatment of normal kidney cells grown in tissue cultures. A 45,500-dalton protein was found to interact firmly with Ca2+ that entered into attached HeLa cells or fibronectin-treated spinner cells. This Ca2+-associated protein was detected by lithium dodecyl sulfate gel electrophoresis at 0 degrees C after 30 s of exposure to radioactive Ca2+. In tumor cells without fibronectin treatment, the radioactive band was not seen under the same conditions, even after 10 min incubation with 45Ca2+. In fibronectin-treated tumor cells, addition of Ca2+ to buffered solutions resulted in increased phosphorylation of a protein in the 45,000-dalton region. The phosphorylated protein band which appears to be associated with the cytoskeleton can be resolved by isoelectric focusing into four polypeptide chains. The relation of these observations to the cascade of protein kinases involved in the phosphorylation of the beta-subunit of the (Na+-K+)-ATPase is discussed.
Congenital Hypothyroid Female Pax8-Deficient Mice Are Infertile Despite Thyroid Hormone Replacement Therapy (2006)

Absence of the Pax8 gene results in congenital hypothyroidism in mice, and mutations of the Pax8 gene have been associated with thyroid hypoplasia in humans. As in humans, treatment of congenital hypothyroid Pax8 null mice with thyroxine normalizes the known deficits. However, we report here that thyroxine-substituted female Pax8(-/-) mice are infertile because they lack a functional uterus revealing only remnants of myometrial tissue. In addition, the vaginal opening is absent. Interestingly, oviduct, cervix, and upper parts of the vagina are not affected, although Pax8 expression has been described in the entire Müllerian duct before. Because the natural outflow of the oviduct is impaired, a hydrosalpinx develops frequently. Folliculogenesis, ovarian hormone production, and transcription of pituitary hormones are in a normal range. Thus, infertility in Pax8(-/-) mice seems to be due to a defect in development of the Müllerian duct rather than to hormonal imbalance, pointing to a direct morphogenic role for Pax8 in uterine development. Because we demonstrated Pax8 expression not only in the uterine epithelium of mice but also in the human endometrium, it remains to be elucidated whether adequate development of the uterus may also be affected in congenital hypothyroid female patients with mutations in the Pax8 gene.
Development of ionic liquid swelled poly-electrolyte membranes for use in dye-sensitized solar cells (2012)

Poly(diallyldimethylammonium iodide) (poly(DADMAI)) was obtained from poly(diallyldimethylammonium chloride) (poly(DADMAC)), via a simple ion exchange. This novel polyelectrolyte was then swelled with 1-alkyl-3-methyl imidazolium iodide and used in dye-sensitized solar cells (DSSC). It was hypothesized that the swelled polyelectrolyte would combine the excellent performance of low viscosity electrolyte solvents with the high stability of low vapor pressure solid-state electrolytes, leading to a high performance and an improved longevity in DSSC electrolytes. A factorial design was implemented to determine the effects of polymer type, polymer molecular weight, ionic liquid loading and ionic liquid alkyl chain length. High power conversion efficiencies achieved 1.60% for low molecular weight poly(DADMAI) swelled with 1-hexyl-3-methyl imidazolium iodide and after 45 days 41.0% of this initial power conversion efficiency was retained. This is a substantial improvement over acetonitrile electrolyte DSSC, whose longevity was only a few hours despite showing an initial 2.34% power conversion efficiency.
Effect of ion-beam parameters on in-plane texture of yttria-stabilized zirconia thin films (2001)

Biaxially textured thin films of 8-mole%-yttria-stabilized zirconia (YSZ) were deposited by ion-beam-assisted deposition (IBAD) on polished Hastelloy-C tapes. These films serve as epitaxial template layers for highly textured Y-Ba-Cu-O superconductor thin films. YSZ films were deposited to a gross thickness of /spl ap/=1.6 /spl mu/m by electron beam evaporation. A 300-eV Ar/10% O/sub 2/ ion beam bombarded the substrate at an off-normal angle during deposition, the ion-to-atom arrival ratio (r-value) was varied by independently adjusting the deposition rate and the ion current density. X-ray pole figures and /spl phi/ scans were used to investigate in-plane texture, profilometry and spectral reflectivity were utilized to measure the net film thickness. A two-dimensional texture/thickness contour map was generated and used to optimize the in-plane texture of the YSZ and to minimize processing time.
Chemical modification of tyrosine-38 in j>.-hydroxybenzoate hydroxylase from Pseudomonas fluorescens by 5'-Pfluorosulfonylbenzoyladenosine: A probe for the elucidation of the NADPH binding site? (1987)

Chemical modification of tyrosine-38 in j>.-hydroxybenzoate hydroxylase from Pseudomonas fluorescens by 5'-Pfluorosulfonylbenzoyladenosine: A probe for the elucidation of the NADPH binding site? was published in Flavins and Flavoproteins 1987 on page 549.
Direct Observation of the Ferric-Porphyrin Cation Radical as an Intermediate in the Phototriggered Oxidation of Ferric- to Ferryl-Heme Tethered to Ru(bpy)<sub>3</sub>in Reconstituted Myoglobin (1999)

Using semisynthetic myoglobins (Ru(bpy)3-Mbs) with covalently appended Ru(bpy)3 (bpy = 2,2‘-bipyridine), an oxidized Mb is photoproduced through an intramolecular electron abstraction reaction as a key step. UV−vis spectra, electron paramagnetic resonance measurements, and reactivity tests identify the photooxidized Mb as a ferryl species (i.e., Fe4+-heme). By circular dichroism (CD) spectroscopy, high-performance liquid chromatography (HPLC), and SDS−polyacrylamide gel electrophoresis (SDS−PAGE), it was confirmed that the photooxidation proceeds without damage of the protein structure. Significantly, we report the first direct observation of ferryl-Mb photogeneration via the intermediate porphyrin cation radical. As a consequence of this observation and proposed mechanism, the rate constants for each step can be clearly determined. The photoexcited Ru2+(bpy)3 is oxidatively quenched by [Co(NH3)5Cl]2+, a sacrificial acceptor, to produce Ru3+(bpy)3, which then proceeds to abstract an electron from the porphyrin ring with a first-order rate constant of 7.1 × 105 s-1, in the first step. The electron transfer is followed by iron(III) oxidation by the porphyrin radical with concurrent deprotonation (a first-order rate constant of 4.0 × 104 s-1 at pH 7.5, and 2.0 × 105 s-1 at pH 9.0) in the second step. Consistent with this mechanism, it is demonstrated that the rate of the fast step of the porphyrin radical generation is independent of pH, whereas the slower step of ferryl-heme formation is dependent on pH. Simulation of the detailed pH dependence of the kinetics clearly shows that the deprotonation−protonation equilibrium of the protein matrix can control the ferryl-heme generation in a heme pocket of Mb.
Educação em administração. Educando administradores além das fronteiras (2003)

Borders of different kinds get in the way of management education. Six years of experience with the International Masters Program in Practicing Management has suggested how we might break down these borders, to get beyond “students”, beyond “globalization”, beyond “teaching”, and beyond the business functions. The management education classroom should be a place where managers can reflect thoughtfully on their experience.
Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study (2019)

Previous studies have reported a positive association between the urinary sodium-to-potassium (Na/K) ratio and hypertension, and multiple measurements of the casual urinary Na/K ratio are more strongly correlated with the 24-h urinary Na/K ratio than a single measurement. Multiple measurements of the urinary Na/K ratio might be more strongly associated with hypertension. We aimed to determine the association between multiple measurements of the casual urinary Na/K ratio and home hypertension compared with a single measurement. A population-based cross-sectional study was performed in Miyagi Prefecture, Japan. Subjects were over 20 years old and participated in the Tohoku Medical Megabank Project Cohort Study. We targeted 3273 subjects who borrowed home blood pressure (HBP) monitors and urinary Na/K ratio monitors for 10 consecutive days. The association between the urinary Na/K ratio and home hypertension (HBP ≥ 135/85 mmHg or under treatment for hypertension) was examined using multiple logistic regression models. To compare the prediction of home hypertension using multiple measurements with that using a single measurement, we calculated the area under the receiver operating characteristic curve (AUROC). Multiple measurements of the urinary Na/K ratio strongly related to home hypertension were better than 1 or 2 days of measurement (adjusted odds ratio of home hypertension per unit increase in urinary Na/K ratio over 6 days: 1.13-1.15). The AUROC of the urinary Na/K ratio measurement for home hypertension was stable after 5 days (AUROC = 0.779). In conclusion, multiple measurements of the urinary Na/K ratio are strongly related to home hypertension. This finding suggests that multiple measurements of the urinary Na/K ratio are useful for evaluating home hypertension.
Office arthroscopy: A diagnostic alternative (1992)

Twenty patients with enigmatic knee symptoms were selected for evaluation by both magnetic resonance imaging (MRI) and office arthroscopy. Office arthroscopy was performed in a standard examination room using a miniature (1.7 mm) fiberoptic arthroscope under local anesthesia. All MRI scans were performed on a state-of-the-art 1.5-T magnet unit, and included specialized cartilage sequences in 7 patients. In 14 patients, 26 areas showed articular cartilage changes by arthroscopy (grade 2-3). Only nine of these areas were detected by MRI (sensitivity 34.6%). There were five false-positive and four false-negative readings of meniscal tears by MRI as compared with office arthroscopy. These results improved when postoperative menisci were excluded. Only one of three anterior cruciate ligament (ACL) disruptions identified by MRI could be verified by arthroscopy. The one posterior cruciate ligament (PCL) disruption was confirmed by both techniques. MRI was superior to arthroscopy in identifying bone contusions, subchondral sclerosis, and medial cruciate ligament (MCL) sprains. Office arthroscopy is an accurate and cost-efficient alternative to MRI in diagnostic evaluation of knee pathology in patients with enigmatic symptomatology.
Developing a professional doctorate in computing (2004)

Pace University's Doctor of Professional Studies in Computing program, a fusion of academic and professional cultures, started as a venture into largely uncharted educational territory. One part of the mission was, and remains, a one hundred percent student retention rate, with each student successfully defending a dissertation with original research in three years. Yet, throughout, the students retain full-time employment as high-level computing and IT professionals. Another part of the mission is to provide breadth and currency across the computing disciplines (specifically, computer science, information systems, and telecommunications) as well as depth in annually selected areas of emerging technology. This is in a context in which entering students have master's degrees and generally at least five years of professional experience in diverse computing-related areas and therefore lack a common foundational background. As a new program at the University and in the country, penetrating assessments have been conducted each semester. This report describes the assessments, the anticipated and unanticipated challenges, and the steps that have made the evolutionary development of this program successful.
Osteopontin Deficiency Induces Parathyroid Hormone Enhancement of Cortical Bone Formation (2003)

Intermittent PTH treatment increases cancellous bone mass in osteoporosis patients; however, it reveals diverse effects on cortical bone mass. Underlying molecular mechanisms for anabolic PTH actions are largely unknown. Because PTH regulates expression of osteopontin (OPN) in osteoblasts, OPN could be one of the targets of PTH in bone. Therefore, we examined the role of OPN in the PTH actions in bone. Intermittent PTH treatment neither altered whole long-bone bone mineral density nor changed cortical bone mass in wild-type 129 mice, although it enhanced cancellous bone volume as reported previously. In contrast, OPN deficiency induced PTH enhancement of whole-bone bone mineral density as well as cortical bone mass. Strikingly, although PTH suppressed periosteal bone formation rate (BFR) and mineral apposition rate (MAR) in cortical bone in wild type, OPN deficiency induced PTH activation of periosteal BFR and MAR. In cancellous bone, OPN deficiency further enhanced PTH increase in BFR and MAR. Analysis on the cellular bases for these phenomena indicated that OPN deficiency augmented PTH enhancement in the increase in mineralized nodule formation in vitro. OPN deficiency did not alter the levels of PTH enhancement of the excretion of deoxypyridinoline in urine, the osteoclast number in vivo, and tartrate-resistant acid phosphatase-positive cell development in vitro. These observations indicated that OPN deficiency specifically induces PTH activation of periosteal bone formation in the cortical bone envelope.
Uroguanylin, an Intestinal Natriuretic Peptide, Is Delivered to the Kidney as an Unprocessed Propeptide (2008)

Orally delivered salt stimulates renal salt excretion more effectively than does iv delivered salt. Although the mechanisms that underlie this "postprandial natriuresis" are poorly understood, the peptide uroguanylin (UGn) is thought to be a key mediator. However, the lack of selective assays for UGn gene products has hindered rigorous testing of this hypothesis. Using peptide-specific assays, we now report surprisingly little UGn in rat intestine or plasma. In contrast, prouroguanylin (proUGn), the presumed-inactive precursor of UGn, is plentiful (at least 40 times more abundant than UGn) in both intestine and plasma. The intestine is the likely source of the circulating proUGn because: 1) the proUGn portal to systemic ratio is approximately two under normal conditions, and 2) systemic proUGn levels decrease rapidly after intestinal resection. Together, these data suggest that proUGn itself is actively involved in enterorenal signaling. This is strongly supported by our observation that iv infusion of proUGn at a physiological concentration produces a long-lasting renal natriuresis, whereas previously reported natriuretic effects of UGn have required supraphysiological concentrations. Thus, our data point to proUGn as an endocrine (i.e. circulating) mediator of postprandial natriuresis, and suggest that the propeptide is secreted intact from the intestine into the circulation and processed to an active form at an extravascular site.
Cell-mediated cytotoxicity to porcine aortic endothelial cells is not dependent on galactosyl residues when baboon peripheral blood lymphocytes are previously primed with pig xenoantigens (2003)

Galactosyl knockout pigs could solve hyperacute rejection and also prevent the activation of NK cells even after xenogeneic priming. T cells will then be the next hurdle for the success of xenografting.
Biosynthetic Investigations on Pyridazomycin (1994)

An unexpected amino acid metabolism is used by a subspecies of the soil bacterium Streptomyces violaceoniger to produce the antifungal antibiotic pyridazomycin 1-C1. Feeding studies with isotopically labeled precursors indicate that 1 is constructed from ornithine, glycine, and probably oxaloacetate.
Exocytosis in normal anterior pituitary cells. Quantitative correlation between growth hormone release and the morphological features of exocytosis. (1988)

We have used high-pressure freezing techniques to study exocytosis in rat anterior pituitary cells. The cells were either unstimulated or exposed to 1 nM growth hormone releasing factor (GRF) for 10 min before ultrarapid freezing. The magnitude of growth hormone (GH) release was then correlated with the number of exocytotic events observed with freeze-fracture electron microscopy. High-pressure freezing of unfixed and uncryoprotected specimens permits cryofixation of samples up to 1 mm diam (0.5 mm thick) without ice crystal damage, and arrests exocytotic events within 10 ms. Our studies comparing conventionally fixed specimens with those prepared by high-pressure freezing confirm that areas of intramembrane particle clearing at potential exocytotic sites are an artifact of conventional fixation and/or cryoprotection techniques. The cells exposed to 1 nM GRF released approximately fivefold more GH than did unstimulated cells. Morphologically, we have observed a 3.3-fold increase in the number of exocytotic events in GRF-stimulated cells, 33.7 events/100 micron2 compared with 10.4 events/100 micron2 for unstimulated cells. In additional experiments, we studied the effects of two inhibitors of GRF-induced exocytosis, somatostatin and sodium isethionate. Both compounds elicit the same response, a parallel decrease in exocytotic events and in secreted product. We conclude that high-pressure freezing, combined with freeze-fracture and freeze-substitution processing techniques, is an excellent tool for studying the morphological aspects of exocytosis. In the present investigation, it has allowed us to quantitatively relate the biochemistry and morphology of exocytosis in anterior pituitary cells.
BCILAB: a new tool for brain-computer interfacing (2011)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Can targeting organic anion transporter polypeptide (OATP) genes play a key role in drug therapy (2008)

Commentary to:Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinomalKatrin Wlcek, Martin Svoboda, Franz Sellner, Georg Krupitza, Walter Jaeger, Theresia Thalhammer
Multimedia Internet KEYing (MIKEY) General Extension Payload for Open Mobile Alliance BCAST LTKM/STKM Transport (2007)

This document specifies a new Multimedia Internet KEYing (MIKEY)
General Extension payload (RFC 3830) to transport the short-term key
message (STKM) and long-term key message (LTKM) payloads defined in
the Open Mobile Alliance's (OMA) Browser and Content (BAC)
Broadcast (BCAST) group's Service and Content protection
specification. This memo provides information for the Internet
community.