gebhart/patrepeval huggingface dataset:
Correlative analyses of plasma cytokine/angiogenic factor (C/AF) profile, gender and outcome in a randomized, three-arm, phase II trial of first-line vandetanib (VAN) and/or carboplatin plus paclitaxel (CP) for advanced non-small cell lung cancer (NSCLC) (2007)

7593 Background: VAN (ZD6474) is an oral inhibitor of VEGFR, EGFR and RET. In a phase II trial, 181 patients with advanced NSCLC were randomized to 1st-line treatment with VAN, CP or VAN + CP. Progression free survival (PFS) was prolonged for VAN + CP vs CP (Heymach et al, submitted for ASCO 2007). Exploratory subgroup analyses suggest gender differences in PFS benefit for VAN + CP vs CP (HR 0.47 in females vs 1.05 in males). We performed exploratory analyses of plasma levels of 35 C/AFs to investigate gender differences and potential prognostic or predictive markers. Methods: Plasma was collected at baseline (n = 123; VAN 55, CP 32, VAN + CP 36), day (D) 8 (n = 104), D22 (n = 95), and D43 (n = 83). We used multiplex bead assays to measure 33 plasma C/AFs, including VEGF, basic FGF, EGF, HGF, E-selectin, ICAM-1, MMP-9, multiple chemokines and interleukins (IL). Osteopontin and sVEGFR-2 were measured by ELISA. Cox models were applied on PFS to identify prognostic/predictive markers after rank transformation and adjusted for covariates. Results: Significant gender differences in baseline C/AF levels were seen for IL-15, IL-1RA, IL-2R, MIG, and MIP-1A (all higher in females, all p = 0.022). Controlling for gender and treatment, high baseline E-selectin (p = .01), IL-6 (p = 0.018), and IL-2R (p = 0.008) were adverse prognostic indicators for PFS. Controlling for gender, the tests for treatment by factor interactions (to assess whether treatment effect was different in patients with low and high C/AF levels) were significant for baseline HGF (p = 0.04) and IL-2R (p = 0.008). For both HGF and IL- 2R, low levels were associated with prolonged PFS in the VAN arm, but were not associated with differences in the CP or VAN + CP arms. Significant changes in VEGF (rise) and sVEGFR-2 (decrease) occurred with treatment in the VAN arm; IL12, IL-1RA, MMP-9 and MCP-1 changed in the CP and VAN + CP arms. Conclusions: There are gender differences in PFS benefit from VAN and in plasma C/AF profile. Several C/AFs were of prognostic value, whereas low HGF and IL-2R were predictive of benefit in the VAN but not CP and VAN + CP arms. These gender differences and markers warrant further investigation. [Table: see text]
Reduced Ischemia-Reoxygenation Injury in Rat Intestine After Luminal Preservation With a Tailored Solution (2010)

In conclusion, preservation and reoxygenation injury can be attenuated by luminal preservation with WMEplus.
Spectroscopic studies of charge‐ordering system in organic conductors (2004)

Abstract Charge localization generates a non‐uniform charge distribution in some organic conductors. Phase transitions accompanying such a localization of charge are studied by using infrared and Raman spectroscopy. We first introduce θ‐(BEDT‐TTF) 2 MM′(SCN) 4 (M=Rb, Cs, Tl; M′=Zn, Co) as typical examples of a charge‐ordering system, where BEDT‐TTF is bis(ethylenedithio)tetrathiafulvalene. We apply the same spectroscopic technique to α′‐(BEDT‐TTF) 2 IBr 2 , θ‐(BDT‐TTF) 2 Cu(NCS) 2 , and (TTM‐TTP)I 3 , which show the phase transitions from low‐resistivity to high‐resistivity state, where TTM‐TTP is 2,5‐bis[4,5‐bis(methylsulfonyl)‐1,3‐dithiol‐2‐ylidene]‐1,3,4,6‐tetrathiapentalene.
Low-Speed Wind-Tunnel Test of an Unpowered High-Speed Stoppable Rotor Concept in Fixed-Wing Mode (1991)

An experimental investigation of the M85, a High Speed Rotor Concept, was conducted at the NASA Langley 14 x 22 foot Subsonic Tunnel, assisted by NASA-Ames. An unpowered 1/5 scale model of the XH-59A helicopter fuselage with a large circular hub fairing, two rotor blades, and a shaft fairing was used as a baseline configuration. The M85 is a rotor wing hybrid aircraft design, and the model was tested with the rotor blade in the fixed wing mode. Assessments were made of the aerodynamic characteristics of various model rotor configurations. Variation in configurations were produced by changing the rotor blade sweep angle and the blade chord length. The most favorable M85 configuration tested included wide chord blades at 0 deg sweep, and it attained a system lift to drag ratio of 8.4.
Copper(I)-promoted cycloaddition reactions of pyridine-2-carbonitrile, 2-pyridylacetonitrile and isoquinoline-3-carbonitrile with ketones (1991)

The copper-promoted cycloaddition between nitrogen heterocyclic compounds (pyridine-2-carbonitrile, 2-pyridylacetonitrile and isoquinoline-3-carbonitrile) and ketones (acetone, pentan-2-one and pentan-3-one) has been studied, and a mechanism proposed on the basis of single crystal X-ray analysis, and 1H NMR and IR spectra of intermediate products.
ChemInform Abstract: Spectomycins, New Antibacterial Compounds Produced by Streptomyces spectabilis: Isolation, Structures, and Biosynthesis. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
INFOPLEX (1975)

The effective use of computer systems for large-scale information management rather than numerical computation is still a largely unsolved problem. In this paper important concepts and theories regarding computer architectures for information management are introduced. The underlying concept, hierarchical decomposition, is presented in the next section.
A Large Range Variable Magnification Telescope (1953)

Telescopes which allow a change of magnification of 3 to 1 linear or 10 to 1 in area are well known. A new telescopic system with variable magnification will be demonstrated which has a range of angular magnification of 10 to 1 or a variation of area covered of 100 to 1. The apparent angle of field is 53°. During the changes in magnification the focal deviation is negligibly small and well within the accommodation range of the human eye.
ChemInform Abstract: Fluorescent Signalling of the Brain Neurotransmitter γ‐ Aminobutyric Acid and Related Amino Acid Zwitterions. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Neural Connections of the Retina: Fine Structure of the Inner Plexiform Layer (1965)

One of the basic requirements for a further understanding of the vertebrate retina, and of the central nervous system in general, is to discover more about the organization of the synapses of nerve cells. Most of what we know of retinal organization has come from the study of tissue prepared by the method of Golgi (Cajal, 1894; Polyak, 1941). Golgi-fixed material makes it possible to classify types of cells and to follow the course of their processes. Such material does not show reliably the synaptic contacts a nerve cell makes; for this, electron microscopy is needed. Unfortunately, it is usually difficult to correlate the processes seen under the electron microscope with the geometry of the structures seen by the light microscope.
Highly Regioselective Thioselenation of Acetylenes by Using a (PhS)<sub>2</sub>−(PhSe)<sub>2</sub> Binary System (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTHighly Regioselective Thioselenation of Acetylenes by Using a (PhS)2−(PhSe)2 Binary SystemAkiya Ogawa, Ryoichi Obayashi, Hiromitsu Ine, Yasunori Tsuboi, Noboru Sonoda, and Toshikazu HiraoView Author Information Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565, Japan and Department of Applied Chemistry, Faculty of Engineering, Kansai University, Suita, Osaka 564, Japan Cite this: J. Org. Chem. 1998, 63, 3, 881–884Publication Date (Web):January 16, 1998Publication History Received4 September 1997Published online16 January 1998Published inissue 1 February 1998https://pubs.acs.org/doi/10.1021/jo971652hhttps://doi.org/10.1021/jo971652hbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views645Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Disulfides,Hydrocarbons,Irradiation,Mathematical methods,Reactivity Get e-Alerts
Assessment of ejaculate quality and sperm characteristics in turkeys: sperm mobility phenotype is independent of time (1998)

Given a pool of genetically superior male turkeys, the subsequent selection of toms as semen donors for artificial insemination should be based upon criteria that are predictive of the tom's fertility and fecundity over the course of a production cycle. Recently, sperm mobility phenotype has been shown to correlate highly with fertility. Therefore, the objectives of this study were to determine: 1) whether sperm mobility phenotypes of individual toms were independent of time, and 2) the extent to which traditional semen quality variables changed as a function of time during the study interval. Sperm mobility phenotype was determined by objectively measuring the ability of sperm to penetrate 2% Accudenz solution at body temperature. During the initial assessments of a flock (n = 94), sperm mobility indexes (SMI) were significantly higher for the High Mobility Phenotype toms (56.61 +/-1.03% SMI) compared to the Low Mobility Phenotype (30.46+/-1.27% SMI, P < or = 0.0001) toms. Over the 5 mo of this study, the High Mobility Phenotype toms consistently had higher (P < or = 0.05) SMI values than the Low Mobility Phenotype toms, with SMI values similar to those of the initial screen. Ejaculate volume, concentration, and plasma membrane integrity showed no significant differences between phenotypes (P > or = 0.05). Sperm viability remained significantly lower (P < or = 0.05) over the course of this study for the High Mobility Phenotype toms than for the Low Mobility Phenotype toms. Because sperm mobility phenotype remained consistent through time, the Sperm Mobility Test provides a potentially important tool for selecting semen donors in turkeys.
Calculations in the Liquid-Drop Model of Fission (1947)

The liquid-drop model of fission as developed by Bohr and Wheeler and others has been studied with the use of an electronic calculator, the Eniac. Classical deformation energies have been calculated for many shapes not all near-spherical. The shapes considered were axially and primarily, but not exclusively, bilaterally symmetric, and single-valued in polar representation. Previous calculations are confirmed and extended. Agreement with observed fission thresholds and spontaneous fission rates is obtained. No explanation of asymmetric fission is found.
Genetic Polymorphisms in Xenobiotic Clearance Genes and Their Influence on Disease Expression in Hereditary Nonpolyposis Colorectal Cancer Patients (2006)

Evidence from this study is not conclusive, but our data suggest that the CYP1A1 influences disease expression in individuals with HNPCC.
Metabolism of Imidacloprid in Workers of <i>Reticulitermes flavipes</i> (Isoptera: Rhinotermitidae) (2010)

Abstract The chloro-nicotinyl insecticide imidacloprid is used extensively as a soil treatment against subterranean termites. We conducted the first study of the metabolic fate of imidacloprid in termites, by exposing workers of the eastern subterranean termite, Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae) to radiolabeled imidacloprid through topical application and ingestion. Several days after topical application, we detected up to 11 radiolabeled compounds. The parent compound, IMI, and the following six metabolites were identified by liquid chromatography/mass spectrometry: olefin-imidacloprid (major metabolite), 4/5-OH imidacloprid, 4,5-di-OH imidacloprid, des-nitro olefin imidacloprid, des-nitro imidacloprid, and a glucuronide conjugate of des-nitro imidacloprid (des-nitro IMI-glu). Over time, detoxification of imidacloprid proceeded from less polar to more polar compounds, with des-nitro IMI-glu seeming to be the ultimate, major end product in surviving termites. Degradation of imidacloprid was limited to internal tissues of the termite. Workers fed wood treated with imidacloprid or provided with a treated substrate (sand) had metabolitic profiles similar to topically treated termites. Termites fed imidacloprid or exposed to it in soil excreted detectable amounts of all of the identified metabolites. Finally, we determined that imidacloprid metabolites were less toxic to termites than imidacloprid itself. Only the olefin-imidacloprid and 5-OH imidacloprid caused morbidity in termites exposed to sand treated with these compounds, but at concentrations ≈10–20-fold higher than the parent imidacloprid. Our results shed light on the metabolic pathway used by termites to detoxify imidacloprid and show how metabolism plays a key role in determining the availability of the active ingredient and its various metabolites for transfer among workers within the colony.
Masked and Filtered Simulation of Hearing Loss (1986)

Hearing threshold configuration of the impaired ear was simulated via two different methods in the normal ear of each of 6 subjects with unilateral sensorineural hearing loss. The two hearing loss simulation methods were frequency-specific attenuation (filtering), and masking by shaped masking noise. Identification responses to 20 consonant-vowel nonsense syllables were obtained from the normal ear of each subject in the two hearing loss simulation conditions, as well as from the impaired ear. Speech data were scored both for overall percent correct consonant recognition and for error patterns on a set of eight consonant features. The computed correlation between gross error difference scores and a similarity metric for feature error pattern was essentially zero, indicating that these may be relatively independent measures of speech recognition, and thus may reflect different aspects of subjects' behavior. For 3 subjects, both masking and filtering successfully simulated the effects of sensorineural hearing loss on consonant feature error patterns. For 1 subject, only filtering produced feature error patterns similar to those of the impaired ear. For the remaining subjects, neither simulation was successful.
Anisotropic Crystalline Protein Nanolayers as Multi‐Functional Biointerface for Patterned Co‐Cultures of Adherent and Non‐Adherent Cells in Microfluidic Devices (2014)

The spatial arrangement of cells in their microenvironment is known to significantly influence cellular behavior, thus making the control of cellular organization an important parameter of in vitro co‐culture models. However, recent advances in micropatterning co‐culture methods within biochips do not address the simultaneous cultivation of anchorage‐dependent and non‐adherent cells. To address this methodological gap we combine S‐layer technology with microfluidics to pattern co‐cultures to study the cell‐to‐cell and cell‐to‐surface interactions under physiologically relevant conditions. We exploit the unique self‐assembly properties of SbpA and SbsB S‐layers to create an anisotropic protein nanobiointerface on‐chip with spatially‐defined cytophilic (adhesive) and cytophobic (repulsive) properties. While microfluidics control physical parameters such as shear force and flow velocities, our anisotropic protein nanobiointerface regulates the biological aspects of the co‐culture method including biocompatibility, biostability, and affinity to non‐adherent cells. The reliability and reproducibility of our microfluidic co‐culture strategy based on laminar flow patterned protein nanolayers is envisioned to advance in vitro models for biomedical research.
Prediction of cut-off frequency from the maximum slope of a transmittance scan of an ideal edge (1982)

This study has empirically shown that the maximum slope of an ideal edge scan in transmittance versus position is an excellent indicator of the cut-off frequency at which a microdensitometer system's modulation transfer function goes to zero. It was found that numerical aperture of collection objective, scanning slit width and alignment, system focus, and sampling interval are parameters which must be carefully chosen and set-up when implementing or using this slope technique to check system performance.
Comparison of Lutein Bioavailability from Vegetables and Supplement (2003)

Lutein is a carotenoid present in dark green leafy vegetables and it may be involved in the prevention of several diseases related to oxidative stress. The aim of this study was to evaluate bioavailability of lutein from different food sources (150 g spinach and 200 g broccoli) and a supplement in oil (300 mg VEGEX), all providing about 9 mg lutein. Eight healthy females were instructed to eat a low-carotenoid diet for the period of experimentation. On three different occasions, three weeks apart, volunteers ate the lutein sources together with 10 g olive oil and 40 g bread. Blood samples were collected just before eating, every two hours for 12 hours, and at 24, 32, 56, 80 and 104 hours. Lutein concentration increased significantly after six to eight hours and peaked after 10-12 hours, with the highest concentration reached after VEGEX intake. Lutein concentration remained significantly elevated for up to 80 hours (VEGEX and spinach). On the whole, our results suggest that the intake of one single dose of lutein from different sources is able to bring about a significant plasma response in the short term.
Use of KCl Aqueous Electrolyte for 2 V Manganese Oxide/Activated Carbon Hybrid Capacitor (2002)

This study reports a hybrid capacitor in neutral KCl aqueous electrolyte, which consists of amorphous manganese oxide as a cathode and activated carbon as an anode. The electrochemical performance of the hybrid capacitor is characterized by cyclic voltammetry and a dc charge/discharge test. The hybrid capacitor shows ideal capacitor behavior with an extended operating voltage of 2 V. The extended operating voltage is preferentially attributed to having asymmetric electrodes with different stable voltage windows and good electrochemical stability in neutral KCl aqueous electrolyte. According to the extended operating voltage, the energy density of the hybrid capacitor at a current density of 0.25 A/g, was found to be 28.8 Wh/kg which is comparable to that of an amorphous ruthenium oxide capacitor (26.7 Wh/kg). The hybrid capacitor also shows no degradation of capacitance during 100 cycles except an initial loss of 7% within a few cycles. © 2002 The Electrochemical Society.
ChemInform Abstract: Insoluble Polymer‐Supported Organotin Reagents (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vegan-vegetarian diets in pregnancy: danger or panacea? A systematic narrative review (2015)

The evidence on vegan-vegetarian diets in pregnancy is heterogeneous and scant. The lack of randomised studies prevents us from distinguishing the effects of diet from confounding factors. Within these limits, vegan-vegetarian diets may be considered safe in pregnancy, provided that attention is paid to vitamin and trace element requirements.
Assessment of the safety margin of vadocaine hydrochloride in man. (1988)

Vadocaine hydrochloride (2',4'-dimethyl-6'-methoxy-3-(2-methylpiperidyl)propionanilide+ ++ hydrochloride, OR K-242-HCl; INN: vadocaine) is an anilide derivative with antitussive and local anaesthetic action. The safety of this new compound was studied in 8 healthy male volunteers in a Phase I clinical trial. Vadocaine was administered orally as a single dose of 50, 100, 200, 300, 400 and 500 mg. At the two highest dose levels used, 400 and 500 mg, vadocaine induced side-effects originating in the central nervous system; ECG analysis revealed small prolongations in the P-Q interval and QRS complex after 400 and 500 mg. At a dose of 500 mg the P-Q interval was prolonged by a maximum of 38% (184 ms at 0.5 h; 134 ms pre-dose). The compound had no effect on blood and urinary parameters measured for safety evaluation. On the basis of these results, a 300 mg dose of vadocaine appears to be safe in man in all respects. This dose level is 10 times the therapeutic dose (30 mg). Vadocaine is sufficiently safe for future clinical trials in patients with cough.
A neutron diffraction study of the acid form of zeolite Y and its complex with benzene (1995)

A powder neutron diffraction study of the structures of D-Y [Fd3m, a= 24.722(1)Å, Rp= 2.52%, Rwp= 3.32%] and its complex with benzene [Fd3m, a= 24.712(2)Å, Rp= 3.24%, Rwp= 4.27%] shows that benzene molecules are located above the six-ring window in the supercage and in the plane of the twelve-ring window, and that no redistribution of deuterium atoms occurs upon adsorption of benzene.
Synthesis of New Dinucleotide mRNA Cap Analogs Containing 2, 6-Diaminopurine Moiety (2010)

The first example of the synthesis of cap analog derivatives having 2, 6-diaminopurine nucleoside has been described. The desired modified cap analogs m7G[5]ppp[5]2-aminoA 6 and m2 7,3OG[5]ppp[5] 2-aminoA 7 were obtained from the coupling reaction of imidazolide salt of 2-amino adenosine [5] monophosphate with its corresponding TEA salt of m7GDP in the presence of ZnCl2 as a catalyst in 73% and 64% yield, respectively. The structures of new cap analogs were confirmed by LC/MS, 1H and 31P NMR.
The interface of GaP(100) and H<sub>2</sub>O studied by photoemission and reflection anisotropy spectroscopy (2013)

We study the initial interaction of adsorbed H2O with P-rich and Ga-rich GaP(100) surfaces. Atomically well defined surfaces are prepared by metal-organic vapour phase epitaxy and transferred contamination-free to ultra-high vacuum, where water is adsorbed at room temperature. Finally, the surfaces are annealed in vapour phase ambient. During all steps, the impact on the surface properties is monitored with in situ reflection anisotropy spectroscopy (RAS). Photoelectron spectroscopy and low-energy electron diffraction are applied for further in system studies. After exposure up to saturation of the RA spectra, the Ga-rich (2 × 4) surface reconstruction exhibits a sub-monolayer coverage in form of a mixture of molecularly and dissociatively adsorbed water. For the p(2 × 2)/c(4 × 2) P-rich surface reconstruction, a new c(2 × 2) superstructure forms upon adsorption and the uptake of adsorbate is significantly reduced when compared to the Ga-rich surface. Our findings show that microscopic surface reconstructions of GaP(100) greatly impact the mechanism of initial interface formation with water, which could benefit the design of e.g. photoelectrochemical water splitting devices.