gebhart/patrepeval huggingface dataset:
Metal Ion Interactions and Glutamine Synthetase Activity<sup>*</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal Ion Interactions and Glutamine Synthetase Activity*Carl MonderCite this: Biochemistry 1965, 4, 12, 2677–2686Publication Date (Print):December 1, 1965Publication History Published online1 May 2002Published inissue 1 December 1965https://pubs.acs.org/doi/10.1021/bi00888a017https://doi.org/10.1021/bi00888a017research-articleACS PublicationsRequest reuse permissionsArticle Views187Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibitory effects of tannins on superoxide-induced histamine release from rat peritoneal mast cells (1995)

Previously, we demonstrated that potassium superoxide (KO2) elicited degranulation and histamine release from rat peritoneal mast cells by biological reactions. In the present study, we investigated the effects of 20 tannins and 10 antiallergic drugs on KO2 and compound 48/80 (48/80)-induced histamine release from rat peritoneal mast cells. Rat peritoneal mast cells were preincubated with various concentrations of tannins or antiallergic drugs at 37°C for 15 min, and K02 (10 mM) or 48/80 (0.5 μ g/ml) were added. The reactions were continued for 20 min and terminated by chilling the test tubes in an ice bath. The amount of histamine in the supernatant and the residual histamine content were determined fluorometrically. The pretreatment with tannins (1-100 μ M), which have many hexahydroxydiphenoyl (HHDP) groups and galloyl groups, prevented K02-induced histamine release, significantly. Higher molecular weight tannins prevented 48/80-induced histamine release, significantly. The pretreatment with azelastine, astemizole, ketotifen and epinastine prevented K02-induced histamine release, dosedependently. On the other hand, DSCG, repirinast, ibudilast and tazanolast had no effect. These findings indicate that the radical-scavenging activities may participate in the inhibitory effects of tannins, and antiallergic drugs may inhibit histamine release due to membrane-stabilizing action. The inhalation of tannins in the airway may prevent airway hypersensitivity.
Identification of Induction Motor in Sinusoidal Mode (2013)

This chapter focuses on the estimation procedures for the induction machine parameters from sinusoidal mode measurements. The methods the chapter presents apply to all types of induction machines and are not based on usual stator measurements and rotation speed. First, the chapter develops the parametric models liable to use this type of estimation procedure. It then presents the most basic methods based on a limited number of measurements such as total rotor leakage model and total stator leakage models. In order to improve estimation precision, it may be necessary to use a larger number of measurements. The chapter presents two methods with this possibility. It presents a method for moving beyond the non-linear programming step, facilitating numeric implementation. Controlled Vocabulary Terms induction motors; rotors; stators
The Role of gas6 in Venous Thrombosis In Vivo. (2009)

Abstract Abstract 3057 Poster Board II-1033 Gas6 is the vitamin-K dependent protein product of growth arrest specific gene 6. A genetic deficiency of this protein protects mice against experimentally induced thrombosis without causing a bleeding diathesis. Protection from thrombosis results from a deficiency in platelet aggregation and secretion. In addition to being expressed by platelets, Gas6 and its receptors are also expressed by vascular cells including the endothelium, an organ known to play a role in the hemostatic balance. While endothelial Gas6 has been shown to promote inflammation and cell survival, it remains unknown if it contributes to the pathophysiology of venous thrombosis. To answer this question, we employed a bone marrow transplantation (BMT) strategy using wild type and Gas6 null mice to create chimeric mice with combined genotypes in the vascular and platelet compartments. Mice were exposed to a dose of radiation optimized to maximize both survival and ablation of recipient marrow. Irradiated mice were then infused with bone marrow cells isolated from the femurs and tibias of donor mice and were allowed a one month recovery period for hematologic reconstitution. Success of marrow uptake was confirmed by PCR. They were then subjected to the Ferric Chloride model of venous thrombosis in the Inferior Vena Cava (IVC). Four groups of transplanted mice were studied. Results from these BMT experiment show a contributing effect by both endothelial as well as platelet Gas6 to thrombus formation (n=8, p<0.01). Mice with combined genotypes (Gas6-/- into WT and WT into Gas6 -/-) show an intermediate thrombus weight suggesting that both vascular and platelet derived Gas6 are both responsible for thrombosis pathology. Therefore, Gas6 at both sites could be potential targets in treating venous thrombosis. Disclosures No relevant conflicts of interest to declare.
Glycine Conjugates in a Lepidopteran Insect Herbivore—The Metabolism of Benzylglucosinolate in the Cabbage White Butterfly, <i>Pieris rapae</i> (2007)

Our recent analyses of the biochemical basis of the metabolism of benzylglucosinolate (2) in Pieris rapae have shown that the assignment of metabolites in the radiochromatograms, as described in our paper ChemBioChem 2006, 7, 1982–1989, was incorrect and led to a wrong conclusion on the designation of the major metabolite of 2 in P. rapae. In recent experiments, we analysed faecal extracts obtained from larvae that had fed on A. thaliana (Col-0) leaves containing 14C-labelled 2, essentially as described in the former paper. However, we used an optimised HPLC system in conjunction with internal and external standards for hippuric acid (9; 2-(benzamido)acetic acid, N-benzoylglycine) and phenylacetylglycine (7). These analyses showed that the major peak in the radiochromatogram (Figure 1 in the 2006 paper), which accounts for about 70 % of the total radioactivity in the HPLC sample, comes from 9 rather than 7 as we had reported. Compound 7 elutes as a minor peak after compound 9. Thus, although the highest specific labelling (47 %) in feeding experiments with 13C-labelled 2 was obtained for 7, most of the glucosinolate is metabolised to 9, which we had previously regarded as a minor metabolite. As discussed in the 2006 paper, compound 9 appears to be a metabolite of other compounds as well; thus leading to the lower specific labelling. The identification of metabolites of 2 by mass spectrometry and NMR spectroscopy as well as the establishment of a putative metabolic pathway from 2 to 7 remain unaffected by our more recent data.
Benchmarking NaI(Tl) electron energy resolution measurements (2002)

A technique for validating electron energy resolution /spl eta//sub e/ results measured using the modified Compton coincidence technique (MCCT) has been developed. This technique relies on comparing measured gamma-ray energy resolution /spl eta//sub /spl gamma// with calculated values that were determined using the measured /spl eta//sub e/ results. These /spl eta//sub /spl gamma// calculations were based on Monte Carlo photon transport simulations, the measured NaI(Tl) electron response, a simplified cascade sequence, and the measured /spl eta//sub e/ results. To demonstrate this technique, MCCT-measured NaI(Tl) /spl eta//sub e/ results were used along with measured /spl eta//sub /spl gamma// results from the same NaI(Tl) crystal. Agreement to within 5% was observed for all energies considered between the calculated and measured /spl eta//sub /spl gamma// results for the NaI(Tl) crystal characterized. The calculated /spl eta//sub /spl gamma// results were also compared with previously published /spl eta//sub /spl gamma// measurements with good agreement (< 10%). In addition to describing the validation technique that was developed in this study and the results, a brief review of the /spl eta//sub e/ measurements made using the MCCT is provided. Based on the results of this study, it is believed that the MCCT-measured /spl eta//sub e/ results are reliable. Thus, the MCCT and this validation technique can be used in the future to characterize the /spl eta//sub e/ of other scintillators and to determine NaI(Tl) intrinsic energy resolution.
Identifying a suitable method for studying thermal comfort in people’s homes (2012)

In the UK, domestic buildings are responsible for a significant amount of overall carbon emissions from buildings. Together with improving the energy efficiency of the existing domestic stock, an in-depth understanding of thermal comfort in homes is necessary to ensure that acceptable levels of thermal comfort are maintained whilst energy use is being reduced. Currently, there is limited knowledge on domestic thermal comfort in the UK as, compared to non-domestic buildings, conducting thermal comfort studies in homes is challenging. Detailed thermal comfort studies are usually considered to be intrusive in domestic environments. Is it therefore possible to conduct thermal comfort studies that are less intrusive and yet scientifically rigorous? With a view to address this question, the study presented in this paper undertook a comparison of two data collection methods. Data collected using a less-intrusive method, referred to as the ‘Silver standard’ was compared with the data collected using the ASHRAE/ISO recommended method (referred to as the ‘Gold standard’). A strong correlation was observed between PMV values obtained using the Silver Standard method and those obtained using the Gold Standard method. The findings suggest that the less-intrusive method devised and tested in this study provides reliable data for thermal comfort evaluations in homes. The findings also suggest that further work is necessary, particularly in winter conditions to comprehensively validate this non-intrusive method.
Obesity and Medical Illnesses in Psychiatric Patients Admitted to a Long-term Psychiatric Facility (2001)

Obesity and associated medical conditions may have an impact on morbidity and even mortality in patients with psychiatric disorders. The authors present the results of a survey of the prevalence of obesity and selected medical conditions among 420 consecutively admitted psychiatric inpatients at a long-stay facility and compare these data with those reported in the literature. Female psychiatric subjects had considerably higher rates of being either overweight or obese (69%) as compared to women in the general U.S. population (51%). Male psychiatric subjects did not differ significantly from their counterparts in the general population in being overweight or obese (nearly 55%). The majority of psychiatric subjects with essential hypertension, diabetes mellitus, dyslipidemias, cardiovascular disease, or sleep apnea were either overweight or obese (72%-87%). In this cross-sectional study, no associations could be deduced between psychotropic drug classes and specific medical conditions. No specific psychiatric diagnostic category was associated with a significantly greater prevalence of any specific medical condition, except that subjects with schizoaffective disorder appeared to have a higher prevalence of type II diabetes mellitus (11.6%). Subjects with predominant substance or alcohol abuse or dependence disorders had a lower prevalence of obesity and associated medical conditions.Obesity-either independently or additively along with a sedentary lifestyle, unhealthy dietary habits, and nicotine dependence-may have a serious impact on coexisting medical comorbidity in psychiatric patients. Judicious monitoring for obesity and rapid pharmacological and nonpharmacological intervention, where appropriate, by concerned clinicians may improve several coexisting medical conditions in psychiatric patients and thereby improve patients' overall quality of life.
Photochromic Fulgides: Part 2. Synthesis and Photochromic Properties of 1-[2,5-Dimethyl-3-furyl or 3-thienyl) ethylidene] diphenylmethylene Succinic Anhydrides and [di(4-fluorophenyl) methylene ]-1-[2,5-dimethyl-3-furyl) ethylidene] Succinic Anhydride (1997)

AnSlRAL'T. Two novel fulgides were prepared and their photochromic properties were studied. The orange fulgides 3a.c undergoes a reversible photochemical reactions to gi:e the deep red 5a.c which is thermally stable at room temperature. Changing the heteroatom from oxygen to sulphur causes a 40nm bathochromic shift of the long maxima wavelength.
A Substorm Triggered by a Sudden Drop in Dynamic Pressure (1998)

In traditional substorm theories the growth phase is driven by an extended period of southward IMF, which transfers large amounts of re-connected magnetic flux into the magnetotail. The subsequent substorm onset may be triggered by a northward turning of the IMF. We investigate the possibility that variations in dynamic pressure may produce these same effects for some substorms lacking a clear IMF Bz signature for both the growth phase and the onset. A sustained increase in dynamic pressure may raise the energy stored in the compressed magnetosphere system (similar to the growth phase), while a subsequent decrease in dynamic pressure may allow some of this stored energy to be released, possibly triggering a substorm. We present a global magnetospheric simulation of such a substorm, which was also imaged by the Ultraviolet Imager (UVI) on the Polar spacecraft. The plasma density rapidly doubled about 90 minutes before the substorm onset with relatively little change in the solar wind velocity and the IMF during this period. Likewise, a sudden decrease in the density almost back to the original levels occurred close to the time of substorm onset, again with no significant change in solar wind velocity or IMF, and thus this dynamic pressure drop may have triggered the substorm. We investigate whether the resulting dynamic pressure increase in the simulation produces a growth phase, a feature that is very successfully modeled by global magnetospheric simulations. We also search for the signature of substorm onset in diagnostics such as the field-aligned currents and the position of the neutral line, if any, in the magnetotail.
Tumorigenic action of beta, proton, electron and alpha radiation in rat skin. Comprehensive progress report, August 1, 1973--July 31, 1976. [UV radiation] (1976)

Rat skin has been studied for a number of years as a model of radiation carcinogenesis in a solid tissue. Accessibility of the skin enables the tumors to be detected early so that growth rate, proliferation rate, and onset times can be established accurately and, of course, the superficial location permits an accurate assessment of doses and a localization of the radiation to the tissue of interest. We have been attempting to establish as accurately as possible the nature of the dose response curve, i.e., the rate of tumor occurrence as of function of radiation dose, and the importance of tumor induction of radiologic factors, such as dose rate, fractionation, dose localization, linear energy transfer and of biologic factors, such as the proliferative state of the hair follicles and epidermis at the time of and subsequent to irradiation. The interaction of radiation and other carcinogens, especially ultraviolet light, is under study because of epidemiologic evidence suggesting a potential synergism for induction of scalp tumors. Radiobiological recovery processes have been studied in tumor response experiments using split doses of radiation separated by various times. The recovery rate for electron induced tumors has been measured, and the oncogenic effects of high LET particles (proton, alpha, argon) are being investigated.
<title>Bandwidth maximization in IP over WDM path networks</title> (2000)

The emerging IP over WDM will be a new layer structure with a help of MPLS and OXC. To use WDM's large transmission capacity effectively, we design IP over WDM networks that reconfigure IP routing and lightpaths every day or month. Using integer linear programming, we formulate a problem that maximizes the network throughput; that is, the sum of the bandwidths allocated to an end-to-end node pair. This formulation is applicable to a network that is composed of twenty nodes and eight wavelengths. In such a network, we show maximization level of the network throughput derived from our formulation.
Mortality in achondroplasia study: A 42‐year follow‐up (2007)

Achondroplasia (ACH) is the most common dwarfing condition having a prevalence of 1/25,000 live births. An increase in overall mortality, age specific mortality up to age 34 years and heart disease-related mortality was first reported in a 1987 study of a large population of ACH individuals. Since this study, concern about premature death, particularly in young adults, has persisted in the ACH population. The present study was undertaken to follow-up the patterns of mortality in a more contemporaneous ACH population. The vital status of 718 ACH individuals from the original study and 75 new ACH individuals was determined through the search of two computerized mortality database. The results showed that the overall mortality and age-specific mortality at all ages remained significantly increased. Rates of death were similar across all 42 years of follow-up suggesting that higher death rates were still occurring in the contemporary ACH population. Accidental, neurological, and heart disease-related deaths were increased in adults. Heart disease-related mortality, between ages 25 and 35, was more than 10 times higher than the general population. Overall survival and the average life expectancy for this ACH population were decreased by 10 years. These results demonstrate that despite advances in the knowledge of the natural history of ACH and health care needs of this population, mortality remains significantly increased. The high rate of heart disease related deaths illustrates the need to identify risk factors in the ACH population and develop treatment interventions accordingly.
42.1: <i>Invited Paper:</i> Display Electronics Required for AMLCDs with Pixel Level Data‐Line Multiplexing (2003)

Abstract The Pixel Level Data‐Line Multiplexing was demonstrated with high‐resolution AMLCDs last year. This technique reduces the numbers of data‐driver chips, data‐lines, and crossovers of data/gate‐lines by one‐half with the a‐Si technology. The advantages of applying this technique are lower‐cost, lower power‐consumption, and higher‐robustness especially for wide format like digital TV. This invited paper will focus on display electronics required to support the Pixel Level Data‐Line Multiplexing array.
6S: Distributing Crawling and Searching Across Web Peers. (2005)

A collaborative peer network application called 6Search (6S) is proposed to address the scalability limitations of centralized search engines. 6S peers depend on a local adaptive routing algorithm to dynamically change the topology of the peer network and search for the best neighbors to answer their queries. We validate prototypes of the 6S network via simulations with 70 − 500 model users based on actual Web crawls and find that the network topology rapidly converges from a random network to a small world network, with clusters emerging from user communities with shared interests. We finally compare the quality of the results with those obtained by centralized search engines such as Google, suggesting that 6S can draw advantages from the context and coverage of the peer collective.
Deuterium Micromapping of Biological Samples by Using the D(T, <i>n</i> ) <sup>4</sup> He Reaction and Plastic Track Detectors (1974)

A technique has been developed to micromap deuterium by using the D(T,n)(4)He reaction and plastic track detectors. Labeling of cells with subpicogram quantities of deuterium was demonstrated. The technique was used to localize human lymphocytes transformed in vitro.
Using Context in Machine Translation of Spoken Language (1995)

: We report on techniques for using discourse context to reduce ambiguity and improve translation accuracy in a multi-lingual (Spanish, German, and English) spoken language translation system. The techniques involve statistical models as well as knowledge-based models including discourse plan inference. This work is carried out in the context of the Janus project at Carnegie Mellon University and the University of Karlsruhe. 1 Introduction Machine Translation of spoken language encounters all of the difficulties of written language (such as ambiguity) with the addition of problems that are specific to spoken language such as speech disfluencies, errors introduced during speech recognition, and the lack of clearly marked sentence boundaries. Fortunately, however, we can take advantage of the structure of task-oriented dialogs to help reduce these difficulties. In this paper we report on techniques for using discourse context to reduce ambiguity and improve translation accuracy in a mul...
A 3-5 GHz RF Receiver Front-End for UWB Wireless System (2006)

A RF receiver front-end for direct sequence code division multiple access (DS-CDMA) ultrawide band (UWB) wireless system is implemented in 0.18 mum CMOS technology. The receiver includes transmit-receive switch (T/R switch), a low noise amplifier (LNA) and a down-converting mixer. The front-end delivers an average power gain of 10 dB, and an IIP3 of -13 dBm at the wide bandwidth of 3 to 4.7 GHz. In the receive mode, the T/R switch exhibits an insertion loss of 1.45-2.3 dB, a 17-dBm power 1-dB compression point (P1dB), and a 26.2-20.1 dB isolation from 3 to 5 GHz. The wideband LNA achieves an average gain of 21 dB with plusmn2 dB flatness and a noise figure of 3.15-4.8 dB
Elastomeric Polymers. 1. Application of Proton NMR Imaging to the Morphological Study of a Silicone Rubber (2002)

Proton NMR imaging techniques were used to characterize a silicone rubber, intended mainly for biomedical applications, modified by an “in situ” polymerization. The study was aimed at the investigation of the effect of the polymerization on the silicone properties and of the dispersion of the guest polymer inside the host matrix. Before the onset of the reaction, the silicone, swollen either in water or in toluene, was characterized. Any source of inohomogeneities such as air bubbles or defects was localized and measured, and the geometry was recognized. By comparing the signal intensity from images collected before, during and after the polymerization reaction as well as the T1 and T2 relaxation time values, the guest polymer was found almost homogeneously dispersed in the host matrix, without preferential locations and/or agglomerates. The silicone network did not appear significantly altered by the presence of the guest polymer. The occurrence of the “in situ” polymerization reaction was proved by infrared spectroscopy.