gebhart/patrepeval huggingface dataset:
Reducing the toxicity of anticancer therapy: new strategies (1998)

Cytoprotective agents offer opportunities to reduce the treatment-related toxicity of anticancer therapy and perhaps to increase the dose and dose intensity of radiation and chemotherapy. One such agent is amifostine, an organic thiophosphate. Amifostine selectively protects normal tissues and provides broad-spectrum protection for a variety of organs while remaining minimally toxic. Clinical studies have demonstrated that amifostine protects against myelotoxicity, nephrotoxicity, neurotoxicity, mucositis and esophagitis in patients treated with alkylating and platinum agents, paclitaxel and radiation therapy. In addition, preclinical studies suggest the possibility of protection against anthracycline-induced cardiotoxicity and radiation- and chemotherapy-induced mutagenicity. Preclinical and clinical studies have not demonstrated any diminution of antitumor efficacy. Amifostine is well tolerated in doses of 740 or 910 mg/m2. The most common side effects requiring treatment are transient hypotension, which responds to intravenous fluids, and nausea and vomiting, effectively treated with 5-HT3 antagonists and dexamethasone.
A Novel IκB Protein, IκB-ζ, Induced by Proinflammatory Stimuli, Negatively Regulates Nuclear Factor-κB in the Nuclei (2001)

The transcription factor nuclear factor-kappaB (NF-kappaB) plays crucial roles in a wide variety of cellular functions and its activity is strictly regulated by cytosolic inhibitors known as IkappaBs. We here report a new member of the IkappaB protein family, IkappaB-zeta, harboring six ankyrin repeats at its carboxyl terminus. IkappaB-zeta mRNA is strongly induced after stimulation by lipopolysaccharide. The induction of IkappaB-zeta is also observed by stimulation with interleukin-1beta but not by tumor necrosis factor-alpha. In contrast to cytosolic IkappaB-alpha, -beta, and -epsilon, the induced IkappaB-zeta localizes in the nucleus via its amino-terminal region, which shows no homology with other proteins. Transiently expressed IkappaB-zeta inhibits the NF-kappaB activity without affecting the nuclear translocation of NF-kappaB upon stimulation. The expressed IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer. Thus, IkappaB-zeta negatively regulates NF-kappaB activity in the nucleus, possibly in order to prevent excessive inflammation. Moreover, transfection of IkappaB-zeta renders cells more susceptible to apoptosis induced by tumor necrosis factor-alpha. The proapoptotic activity of IkappaB-zeta further suggests that it might be one of key regulators for inflammation and other biologically relevant processes.
Class of constructive asymptotically good algebraic codes (1972)

For any rate <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R, 0 < R < 1</tex> , a sequence of specific <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(n,k)</tex> binary codes with rate <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R_n > R</tex> and minimum distance <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</tex> is constructed such that \begin{equation} \lim_{n \rightarrow \infty} \inf \frac{d}{n} \geq (1 - r ^{-1} R)H^{-1} (1 - r)> 0 \end{equation} (and hence the codes are asymptotically good), where <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</tex> is the maximum of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\frac{1}{2}</tex> and the solution of \begin{equation} R = \frac{r^2}{1 + \log_2 [1 - H^{-1}(1 - r)]}. \end{equation} The codes are extensions of the Reed-Solomon codes over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF(2^m)</tex> With a simple algebraic description of the added digits. Alternatively, the codes are the concatenation of a Reed-Solomon outer code of length <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N = 2^m - 1</tex> with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</tex> distinct inner codes, namely all the codes in Wozeneraft's ensemble of randomly shifted codes. A decoding procedure is given that corrects all errors guaranteed correctable by the asymptotic lower bound on <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</tex> . This procedure can be carried out by a simple decoder which performs approximately <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n^2 \log n</tex> computations.
Transforming growth factor‐β1 rapidly induces Hsp70 and Hsp90 molecular chaperones in cultured chicken embryo cells (1992)

In this report we show that: (1) molecular chaperones in the heat shock protein (hsp) family are a new class of cellular proteins induced by Transforming Growth Factor-beta 1 (TGF beta), a cytokine present in serum, (2) rapid induction of Hsc70 precedes a general increase in protein synthesis and may be a preparatory event, (3) TGF beta is a potent regulator of overall protein synthesis in chicken embryo cells (CEC), and (4) isoforms of Hsp90 with different biochemical properties exist, raising the possibility that they may have different functions. TGF beta can substitute for serum in stimulating synthesis of members of the Hsp90 and Hsp70 families of stress proteins, whereas other cytokines, including PDGF, FGF, and EGF, were not effective nor did they enhance the stimulatory effect of TGF beta on the hsp's. Analysis of the induction of hsp's using one- and two-dimensional polyacrylamide gel electrophoresis indicated that members of the Hsp70 family of molecular chaperones were induced rapidly by TGF beta, reaching maximum rates of accumulation by 5 hours of treatment. Total protein synthesis increased more slowly, undergoing an approximately twofold increase in 24 hours. Using a modified protocol for two-dimensional gel electrophoresis, the Hsp90 protein family was separated into four isoelectric forms, two of which were phosphorylated (Hsp90-2 and -4). These phosphorylated isoforms turned over faster than the unphosphorylated forms of Hsp90. All four isoforms were heat inducible, but only Hsp90-2 and -3 were induced rapidly by TGF beta, again within 5 hours of treatment. The effects of serum on these protein families were similar to those of TGF beta, suggesting that this cytokine may be the serum component primarily responsible for up-regulating members of the Hsp90 and Hsp70 families. We hypothesize that cells rapidly increase their chaperoning capacity for newly synthesized polypeptides in preparation for an increase in the rate of synthesis of proteins up-regulated by TGF beta.
Fuzzy and cross-app replay for smartphone apps (2016)

The behavior of smartphone apps is driven by input from sensors such as GPS, microphone, or camera. Hence the ability to construct test inputs, and send these inputs to the app is essential for testing. Leveraging our prior results in recording and replaying sensor inputs in Android apps we have constructed a new approach that helps automate smartphone app testing by capturing the input log (sensor stream) and using this log in two ways. First, we fuzz (alter) the log in a semantically-meaningful way: by applying principled transformations (e.g., changing GPS coordinates or navigation speed), a new input log is constructed, which represents a new test case. Second, we use the log captured in app A to test an app B which offers similar functionality, e.g., GPS navigation or image recognition. We have applied our approach to several widely-used Android apps and found that the approach is effective: it has revealed new bugs in four popular apps; has produced new test cases that increase coverage; and has produced test cases from logs originating in other apps.
DPD: a distributed program debugger for the REM environment (2003)

The development of a distributed program debugger (DPD) for the remote execution manager (REM) environment is discussed. The model for DPD and REM consists of multiple processors, each with its own private memory and each capable of running several processes. DPD debugs at a higher level of abstraction than sequential debuggers, specifically at the process communication and control level. Synchronization and communication faults are more easily detected when events are the sending and receiving of messages or the creation and termination of processes. When a fault is detected in a distributed program, DPD has the ability to stop the program, roll back, and replay. During the replay, the user can control and change the behavior of the program in order to detect the synchronization faults. A graphical interface is used to show the ordering of events and the communication between processes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cortex and Mind (2005)

Abstract This book explores whether the mental order corresponds to the order of structures, events, and processes in one part of the neural order, namely, the cerebral cortex. For clarity and simplicity, this means the search for a spatial and temporal order in the cerebral cortex that matches the cognitive order in every respect. A change or difference in the cortical order corresponds to a change or difference in the mental order. The principal aim of this book is to map cognitive networks onto cortical networks. It has implications for cognitive neuroscience, neurophysiology, neurobiology, neuroimaging, neurology, neurosurgery, psychiatry, cognitive psychology, and linguistics. The book will also interest students in all the disciplines of neuroscience and can be used as a text or collateral reading in courses on systems neuroscience, behavioral neuroscience, cognitive science, network modeling, physiological psychology, and linguistics.
Acute Myocardial Infarction in Argentina. CONAREC XVII Register (2013)

IntroductionAcute myocardial infarction (AMI) is a major cause of morbidity and mortality in ourcountry. It is very important to have data on the reality of this entity in Argentina asa starting point for the development of prevention policies and treatment improvement.ObjectiveThe aim of the study was to describe demographic variables, situations associated tostress, established treatments, implementation times, in-hospital complications andmedication at discharge of patients with AMI admitted to centers associated to theArgentine Council of Residents in Cardiology (CONAREC).MethodsBetween December 2009 and July 2010, 1182 consecutive patients admitted to 45centers across the country with a diagnosis of AMI with or without ST segment elevationwere included in the study.ResultsMean age was 64 ± 12 years; 705 patients presented ST-segment elevation myocardialinfarction (STEMI) and 477 non- ST-segment elevation myocardial infarction(NSTEMI). In the STEMI group, reperfusion rate was 92% of eligible patients, withprimary angioplasty in 80% of cases. In this group, prehospital time delay was 165minutes and door-to-balloon time was 80 minutes. In the NSTEMI group, coronaryangiography was performed in 75% of patients and 46% underwent angioplasty. Themain complication was the development of heart failure (22% in the STEMI groupand 11% in the NSTEMI group), followed by bleeding and arrhythmias. Mortalitywas 8.8% in the STEMI group and 5.1% in the NSTEMI group.ConclusionsPatients with AMI admitted to centers with medical residency present a high rateof reperfusion and treatment at hospital discharge, in agreement with internationalrecommendations. Aspects to be improved are the high prevalence of risk factors andprolonged prehospital time delays, situations which have not changed in the last 15years.
Toxicological Screening with Formula-Based Metabolite Identification by Liquid Chromatography/Time-of-Flight Mass Spectrometry (2003)

An analytical procedure was evaluated for the comprehensive toxicological screening of drugs, metabolites, and pesticides in 1-mL urine samples by TurboIon spray liquid chromatography/time-of-flight mass spectrometry (LC/TOFMS) in the positive ionization mode and continuous mass measurement. The substance database consisted of exact monoisotopic masses for 637 compounds, of which an LC retention time was available for 392. A macroprogram was refined for extracting the data into a legible report, utilizing metabolic patterns and preset identification criteria. These criteria included +/-30 ppm mass tolerance, a +/-0.2-min window for absolute retention time, if available, and a minimum area count of 500. The limit of detection, determined for 90 compounds, was <0.1 mg/L for 73% of the compounds studied and >1.0 mg/L for 6% of the compounds. For method comparisons, 50 successive autopsy urine samples were analyzed by this method, and the results confirmed by gas chromatography/mass spectrometry (GC/MS). Findings for parent drugs were consistent with both methods; in addition, LC/TOFMS regularly revealed apparently correct findings for metabolites not shown by GC/MS. Mean and median mass accuracy by LC/TOFMS was 7.6 and 5.4 ppm, respectively. The procedure proved well-suited for tentative identification without reference substances. The few false positives emphasized the fact that all three parameters, exact mass, retention time, and metabolite pattern, are required for unequivocal identification.
Cross‐linking of membrane IgM on B CLL cells: dissociation between intracellular free Ca<sup>2+</sup> mobilization and cell proliferation (1988)

It has been shown previously that chronic lymphocytic leukemia (CLL) B cells are frozen at different stages of activation with unique requirements for proliferation. Although most B CLL cells express surface IgM, anti-mu antibodies are able to trigger only some of them to proliferate and/or respond to B cell growth factor (BCGF) or interleukin 2 (IL2), as normal B cells. In this report we extend these observations using three different monoclonal antibodies (mAb) to human mu chain (one mitogenic in soluble form for normal B cells, the two others mitogenic only when coupled on Sepharose 4B beads). Cells from only 3 out of 11 B CLL patients proliferated in the presence of either mitogenic anti-mu. When the early events following surface Ig cross-linking, such as calcium mobilization (by flow cytometry on indo-1-labeled cells), were studied all three mAb in soluble form were able to induce a similar increase in the intracellular free calcium concentration ([Ca2+]i); analogous to [Ca2+]i rise after the mitogenic F(ab')2 anti-mu stimulation. This response was seen only in 8 out of the 12 CLL B cells studied. All B CLL cells, however, proliferate in response to a combination of phorbol ester 12,13-dibutyrate (PBt2) and ionomycin. Therefore, three patterns of response to sIg cross-linking by anti-mu could be distinguished: cells from 4 out of 12 cases proliferate and mobilize Ca2+ upon anti-mu triggering (behaving like resting B lymphocytes); in 4 other cases anti-mu lead to Ca2+ mobilization without cell proliferation; in the last 4 cases neither Ca2+ mobilization, IP3 generation (in the one case studied) nor cell proliferation are observed although these cells do proliferate directly in response to growth factors. Moreover, anti-mu stimulation in this group leads to increased proliferation in response to BCGF and IL2 suggesting an anti-Ig signaling independent of inositol phosphate metabolism. These results are interpreted in terms of differential anti-mu signaling on B cells at different stages of activation.
Energy consumption analysis of video streaming to Android mobile devices (2012)

Energy conservation has become a critical issue around the world. In smart phones, battery power capabilities are not keeping up with the advances in other technologies (e.g., processing and memory) and are rapidly becoming a concern, especially in view of the growth in usage of energy-hungry mobile multimedia streaming. The deficiency in battery power and the need for reduced energy consumption provides motivation for researchers to develop energy efficient techniques in order to manage the power consumption in next-generation wireless networks. As there is little analysis in the literature on the relationship between the wireless environment and the mobile device energy consumption, this paper investigates the impact of network-related factors (e.g., network load and signal quality level) on the power consumption of the mobile device in the context of video delivery. This paper analyzes the energy consumption of an Android device and the efficiency of the system in several scenarios while performing video delivery (over UDP or TCP) on an IEEE 802.11g network. The results show that the network load and the signal quality level have a combined significant impact on the energy consumption. This analysis can be further used when proposing energy efficient adaptive multimedia and handover mechanisms.
Diagnosing adenomyosis: an integrated clinical and imaging approach (2020)

The development of the diagnostic tools allows the physicians to make an accurate diagnosis of adenomyosis by means of non-invasive techniques, representing a major breakthrough, in the light of the clinical consequences of this disease. Furthermore, this technological improvement will open a new epidemiological scenario, identifying different groups of women, with a dissimilar clinical and/or imaging phenotypes of adenomyosis, and this should be object of future research.
What's happening (1999)

article Free Access Share on What's happening Author: Jennifer Bruer View Profile Authors Info & Claims InteractionsVolume 6Issue 5Sept.-Oct. 1999 pp 7–16https://doi.org/10.1145/312683.312691Online:01 September 1999Publication History 0citation623DownloadsMetricsTotal Citations0Total Downloads623Last 12 Months121Last 6 weeks11 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Thermodynamic Research of BN-MgAlON Composite Powders from Boron-rich Slag (2010)

Based on thermodynamic analysis,BN-MgAlON composite powders were synthesized by carbothermal reduction and nitridation from boron-rich slag and carbon black as raw materials.Phase composition and microstructure of products were determined by X-ray diffraction(XRD),energy spectral analysis and scanning electron microscopy.The experimental result showed that B2O3 was transformed into BN,Al2O3 and SiO2 form MgAlON phase which could react with high purity nitrogen and holding time 8h at 1480℃.Reaction products were consisted of MgAlON,BN,CaAl4O7 and Sialon.The results demonstrate that full-fledged,octahedron crystallization can be prepared by the method of CRN.The technique provides a new strategy to comprehensive utilization of boron-rich slag.
Defined polymers = Definierte polymers (1991)

Introduction structure of the spectral collection the decimal classification spectra hydrocarbons CHal polymers CHHal polymers CHN polymers CHO polymers CHS polymers CHaIX polymers CNO polymers CNS polymers CHHall-lal polymers CHHaIN polymers CHHaIO polymers CHHaIS polymers CHNO polymers CHNS polymers CHOS polymers CHaINO polymers CHaINS polymers CHHalHal'O polymers CHHalNO polymers CHHaIOS polymers CHNOS polymers polymers made up of 6 and more elements deuterated polymers boron compounds silicon compounds germanium compounds phosphorus compounds polymers with boron and Si, Ge or P polymers with Si and Ge or P polymers with a heteroelement (B,Si, Ge,P) and a metal organometallic polymers.
Long-term development after treatment of mandibular dysfunction and osteoarthrosis. A clinical-radiographic follow-up and an animal experimental study. (1984)

The purpose of this thesis was to investigate the long-term development of signs and symptoms in patients with temporomandibular joint (TMJ) pain/dysfunction after treatment, to analyse factors of importance for the long-term prognosis, to evaluate TMJ radiography in these disorders and to develop a model for experimental joint lesions where also the effects of intra-articular injections of corticosteroid and hyaluronic acid in such joint lesions were studied. Signs and symptoms of dysfunction in the patients treated for TMJ pain/dysfunction were few at the follow-up and significantly reduced compared with the findings at the start of treatment. Less than one fifth of the patients had had recurrent symptoms of some significance. Poor general health was found to have a negative influence on the prognosis. Few correlations were found between occlusal factors and dysfunction. In patients with extremely long periods of treatment psychosocial factors were evident. The long-term prognosis of TMJ osteoarthrosis was as good as for neuromuscular problems but crepitation often persisted at the follow-up. Radiographic abnormalities of structure and shape of the TMJ generally of a small extent were frequent in patients with TMJ pain/dysfunction both in those examined during the treatment period and in those only radiographed at the follow-up. Findings were frequent also in patients treated for mainly mandibular (neuromuscular) dysfunction. At the follow-up a slight increase in number and extent of abnormalities were found. Signs and symptoms of dysfunction showed poor correlation with the radiographic findings. Decreased number of occluding pair of teeth, as well as crepitation, was however positively correlated to abnormalities of structure and shape. The intra-articular injection of papain in guinea-pig knee-joints constantly resulted in development of joint lesions with individual variations. Treatment of such joint lesions with corticosteroid and hyaluronic acid had little influence on the overall lesions, but the results indicate that hyaluronic acid inhibit granulation tissue formation and development of deviation in shape of the joint components.
Upper Airway Volume Segmentation Analysis Using Cine MRI Findings in Children with Tracheostomy Tubes (2007)

There is a statistically significant change in airway dynamics in children with tracheotomy tubes when breathing via the airway as compared to breathing via the tracheotomy tube.
Translating machine displayable information and documentation (2003)

Discusses the need for translating machine-displayable information and documentation for software products and the need for worldwide related products. Guidelines to follow for translation and linguistic sensitivities are suggested. All products should provide the user with a language that makes it possible to enter, display, store retrieve, distribute, print, and process data. When the English product is designed with the intent that it will be translated, the quality of the translation will make it a more usable and marketable product.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Noise constrained power optimization for dual V/sub T/ domino logic (2002)

In dual threshold voltage techniques, significant subthreshold leakage current is one of the most important design problems. When dual threshold voltage is applied to the domino logic, noise immunity has to be carefully considered because the significant subthreshold current makes dynamic nodes much more susceptible to noise. In this paper, an analytical model for proper keeper transistor sizing to meet noise constraint is presented. Based on the same noise constraint, we propose dual threshold voltage domino logic technique to save power consumption.