gebhart/patrepeval huggingface dataset:
Quantitative evaluation of hypnotically suggested hyperaesthesia and analgesia by painful laser stimulation (1990)

The ability to reduce both clinically and experimentally induced pain by hypnotic suggestion of analgesia is well known. However, the nature of hypnotic analgesia still remains uncertain. Attempts to demonstrate and identify specific psychophysiological mechanisms have, so far, been unsatisfactory. Methodological problems in inducing pain and monitoring physiological responses may be the reason for this lack of success. In the present study, we have attempted to eliminate some of these methodological problems. The sensory and pain thresholds to laser stimulation were determined, and the laser-evoked brain potentials were measured for 8 highly hypnotically susceptible subjects in 3 conditions: (1) waking state, (2) suggestion of hyperaesthesia, (3) suggestion of analgesia. The thresholds were reduced during induced hyperaesthesia and increased during analgesia. During hyperaesthesia sensations could be evoked by laser intensities which were below intensities that could be perceived in the awake state. The amplitude of the evoked brain potentials increased during hyperaesthesia and decreased during analgesia. The latency of the potential remained constant. The perception of pain during hypnosis can change very fast, indicating that slow endogenous mechanisms may play only a minor role in suggested hyperaesthesia/analgesia.
Hybrid offshore HVDC converter with diode rectifier and Modular Multilevel Converter (2016)

This paper presents a hybrid converter for offshore HVDC applications, consisting of diode rectifiers and a Modular Multilevel Converter. The main task of the Modular Multilevel Converter is to support the wind park with auxiliary power during low wind speed periods, thus avoiding an extra AC cable for auxiliary power. Using the Modular Multilevel Converter also during normal operation of the HVDC link can result in a better DC current with a smaller DC line inductance. The proposed solution is validated with a simulation model based on Simulink Plecs and an experimental setup.
Synthesis of Unsymmetrically Substituted Phosphane Oxides ((RRP)-R-1-P-2(O)H) and Phosphinous Acids ((RRPOH)-R-1-P-2) (2014)

This paper describes the synthesis of unsymmetrically substituted phosphinous acids and phosphane oxides featuring at least one electron-withdrawing pentafluoroethyl group. The presence of a diethylamino function as a protecting group allows a selective reaction of RClPNEt2 (R=CF3, C6F5, C6H5) with LiC2F5. On treatment with para-toluenesulfonic acid the isolated aminophosphanes R(C2F5)PNEt2 are readily converted into the corresponding phosphinous acids or phosphane oxides, respectively. Investigation of the tautomeric equilibrium between oxide and acid tautomer revealed (CF3)(C2F5)POH as a stable phosphinous acid, whereas the pentafluorophenyl and phenyl derivatives constitute a solvent dependent equilibrium between the acid and the oxide tautomer.
Glycoengineering the N-acyl side chain of sialic acid of human erythropoietin affects its resistance to sialidase (2012)

During the last years, the use of therapeutic glycoproteins has increased strikingly. Glycosylation of recombinant glycoproteins is of major importance in biotechnology, as the glycan composition of recombinant glycoproteins impacts their pharmacological properties. The terminal position of N-linked complex glycans in mammals is typically occupied by sialic acid. The presence of sialic acid is crucial for functionality and affects the half-life of glycoproteins. However, glycoproteins in the bloodstream become desialylated over time and are recognized by the asialoglycoprotein receptors via the exposed galactose and targeted for degradation. Non-natural sialic acid precursors can be used to engineer the glycosylation side chains by biochemically introducing new non-natural terminal sialic acids. Previously, we demonstrated that the physiological precursor of sialic acid (i.e., N-acetylmannosamine) can be substituted by the non-natural precursors N-propanoylmannosamine (ManNProp) or N-pentanoylmannosamine (ManNPent) by their simple application to the cell culture medium. Here, we analyzed the glycosylation of erythropoietin (EPO). By feeding cells with ManNProp or ManNPent, we were able to incorporate N-propanoyl or N-pentanoyl sialic acid in significant amounts into EPO. Using a degradation assay with sialidase, we observed a higher resistance of EPO to sialidase after incorporation of N-propanoyl or N-pentanoyl sialic acid.
High Substitutional-Sn-Concentration GeSn-on-Insulator by Weak-Laser-Irradiation-Enhanced Solid-Phase Crystallization at Low-Temperature (~170°C) (2017)

2017 International Conference on Solid State Devices and Materials,High Substitutional-Sn-Concentration GeSn-on-Insulator by Weak-Laser-Irradiation-Enhanced Solid-Phase Crystallization at Low-Temperature (~170°C)
Drug Utilization Patterns (2005)

Abstract We review methodological challenges in the observational studies of the patterns and outcomes of drug utilization. First, we address issues related to design and data collection in different studies that rely on administrative databases, discuss their limitations in accounting for clinical indication bias, and outline new opportunities created by the emergence of the integrated electronic patient records. Then, we focus on the different analytical issues related to such complexities as prescriber effects, assessing the impact of policy changes on drug utilization, description and classification of longitudinal patterns of medication use, alternative methods of measuring time‐dependent exposure status and medication dose, use of nonparametric modeling to represent time‐varying, lagged and/or nonlinear effects of exposure.
A Conductometric Analysis Of Portland Cement Pastes And Mortars And Some Of Its Applications (1936)

First Name is required invalid characters Last Name is required invalid characters Email Address is required Invalid Email Address Invalid Email Address
Spray Break-Up Process of Diesel Fuel Investigated Close to the Nozzle (1997)

The most common spray break-up models for fuel atomization are presented and discussed. Different break-up models show different spray characteristics and none of the presented models can explain the phenomena observed in several recent works. Up to now there is no confirmation for one of them. Here, a light sheet technique was used to investigate the spray structures close to the nozzle orifice by means of a new detection optics. The experimental results show a liquid jet which is dispersed with cavitation bubbles especially at the edge of the jet. The bubbles implode next to the orifice and create strong disturbances which are increased by aerodynamic interactions. Based on these observation a new idea of a break-up model has been developed. Additionally the two-phase flow was used to determine the flow velocity close to the nozzle.
Sorption on Deformable Solids. Density Functional Theory Approach (2011)

A modified density functional theory is proposed to describe fluid adsorption and absorption by a solid, the density of which is nonhomogeneous near the interface. The density distribution of the solid is not provided by apriori assumptions, but is obtained via the minimization of an appropriate thermodynamic potential. The theory considers a mixture of two components in a slitlike pore. One of them, the fluid, is in contact with a reservoir containing the same kind of molecules and can be described through a grand canonical ensemble. The other component has strong interactions between its molecules. As a consequence, it forms a solid in the slit which can be treated as a canonical ensemble of a fixed number of molecules. The theory predicts both an intrinsic (in the absence of fluid) change in the solid density near the interface and a solid density variation as the fluid density in the reservoir is changed. In addition, it reveals that the oscillations that occur in the fluid density when the solid density is uniform are damped by the nonuniform solid. The theory provides the amounts of fluid adsorbed as well as absorbed by the solid.
Lymfomu podobný průběh agresivní multisystémové histiocytózy z Langerhansových buněk v dospělosti a přínos PET/ CT vyšetření při hodnocení difuzní metabolické aktivity v plicním parenchymu (2010)

Tato kazuistika popisuje neobvyklý připad agresivni formy
histiocytozy z Langerhansových buněk (LCH) u jinak zdraveho
35leteho muže, ktera zpocatku probihala pod obrazem lymfomu s
vyjadřenými B symptomy (nocni poty, febrilie, hubnuti) a
generalizovanou periferni lymfadenopatii. Přitomen byl rovněž
produktivni kasel a svěděni kůže v oblasti konecniku. Diagnoza
byla stanovena z biopsie lymfaticke uzliny a kůže perianalni
oblasti. Typickým nalezem na HRCT (zobrazeni výpocetni
tomografii s vysokým rozlisenim) bylo dale potvrzeno plicni
postiženi, jehož postupný vývoj z pocatecniho floridniho stadia
charakterizovaneho diseminovanými nodularitami až po konecnou
fazi s poklesem aktivity a rozvojem cystických formaci se nam
serii několika HRCT a PET/CT skenů podařilo zdokumentovat. Po
sběru perifernich kmenových buněk byla u pacienta zahajena
planovana lecba, ktera sestavala celkem ze 3 cyklů monoterapie
s kladribinem, nasledovana 3 cykly kombinovane chemoterapie
(kladribin + cyklofosfamid + metylprednisolon) a doplněna o
kurativni radioterapii perianalni oblasti. Tato lecba uvedla
onemocněni do kompletni remise. Za 2 měsice se vsak znovu
objevily původni B přiznaky, plicni symptomatologie, perianalni
pruritus a nově i bolesti kycli. Předpokladaný relaps LCH byl
histologicky ověřen biopsii lymfaticke uzliny a potvrzen na
restagingovem PET/ CT vysetřeni, ktere rovněž ukazalo
diseminaci onemocněni do kycelnich kosti. Jednalo se tedy o
agresivni, casně relabujici onemocněni indikovane k podani 4
cyklů zachranneho režimu CHOEP (cyklofosfamid + doxorubicin +
vinkristin + etoposid + prednison), ktere byly v březnu roku
2010 zakonceny autologni transplantaci perifernich kmenových
buněk po připravě vysokodavkovou chemoterapii HD BEAM
(karmustin + etoposid + cytarabin + melfalan). Generalizovane
postiženi uzlin tedy nemusi být vždy jen maligni lymfom ci
metastatický rozsev tumoru, ale může se jednat i o LCH. Pokud
jsou přitomny B symptomy, znamena to velmi pravděpodobně
agresivni průběh. Histologicke hodnoceni proliferacni
charakteristiky (dane imunohistochemicky proliferacnim markerem
Ki-67 i morfologicky poctem mitoz) může upozornit na agresivni
formu teto nemoci. Lecba kladribinem (2-chlorodeoxyadenosinem),
ktera se osvědcuje u klasických forem LCH, vsak nemusi mit v
připadě vysoce agresivni formy LCH stejný ucinek jako u LCH s
nizkou proliferacni aktivitou, což je v souladu s dosavadnimi
zkusenostmi s lecbou indolentnich a vysoce agresivnich lymfomů.
Hybridni PET/CT zobrazeni prokazalo v nasi studii vysokou
citlivost při hodnoceni aktivity onemocněni vcetně jejiho
casneho relapsu. V teto praci představujeme novou metodiku
popisu a hodnoceni difuzně zvýsene metabolicke aktivity
plicniho parenchymu pomoci PET/CT vysetřeni a využiti teto
metodiky v ramci sledovani lecebne odpovědi.
Infrared extinction spectra of mineral dust aerosol: Single components and complex mixtures (2012)

Simultaneous Fourier transform infrared (FTIR) extinction spectra and aerosol size distributions have been measured for some components of mineral dust aerosol including feldspars (albite, oligoclase) and diatomaceous earth, as well as more complex authentic dust samples that include Iowa loess and Saharan sand. Spectral simulations for single‐component samples, derived from Rayleigh‐theory models for characteristic particle shapes, better reproduce the experimental spectra including the peak position and band shape compared to Mie theory. The mineralogy of the authentic dust samples was inferred using analysis of FTIR spectra. This approach allows for analysis of the mineralogy of complex multicomponent dust samples. Extinction spectra for the authentic dust samples were simulated from the derived sample mineralogy using published optical constant data for the individual mineral constituents and assuming an external mixture. Nonspherical particle shape effects were also included in the simulations and were shown to have a significant effect on the results. The results show that the position of the peak and the shape of the band of the IR characteristic features in the 800 to 1400 cm −1 spectral range are not well simulated by Mie theory. The resonance peaks are consistently shifted by more than +40 cm −1 relative to the experimental spectrum in the Mie simulation. Rayleigh model solutions for different particle shapes better predict the peak position and band shape of experimental spectra, even though the Rayleigh condition may not be strictly obeyed in these experiments.
ChemInform Abstract: COMPLEX CHEMISTRY OF REACTIVE ORGANIC COMPOUNDS. 16. NITROGEN TRANSFER FROM A A DIAZOALKANE TO A METAL CENTER (1977)

Abstract Die Umsetzung der Tetrahydrofuran‐ Komplexe (I) mit der Diazoverbindung (II) bei ‐80 bis +25°C liefert die säulenchromatographisch abtrennbaren, diamagnetischen Distickstoff‐Komplexe (III).
Correction of Myopia and Astigmatism Using an Ablatable Mask (1994)

The ablatable mask represents a promising modality for the treatment of eyes with both myopia and myopic astigmatism.
A New Approach for Predicting the Variance of Random Decrement Functions (1998)

The Random Decrement (RD) technique is a simple and fast method for estimating the correlation functions of Gaussian processes. The RD functions are estimated as an averaging process in the time domain, which makes the technique simple and fast. If the RD technique is applied to stationary zero mean Gaussian distributed processes the RD functions are proportional to the correlation functions of the processes. If a linear structur is loaded by Gaussian white noise the modal parameters can be extracted from the correlation funtions of the response, only. One of the weaknesses of the RD technique is that no consistent approach to estimate the variance of the RD functions is known. Only approximate relations are available, which can only be used under special conditions. The variance of teh RD functions contains valuable information about accuracy of the estimates. Furthermore, the variance can be used as basis for a decision about how many time lags from the RD funtions should be used in the modal parameter extraction procedure. This paper suggests a new method for estimating the variance of the RD functions. The method is consistent in the sense that the accuracy of the approach is not dependent on neither the physical system nor the actual formulation of the RD technique.
Effects on cancer patients of leukapheresis with the continuous-flow blood cell separator. I. Hematologic and immunologic parameters in vivo. (1975)

A study was undertaken to investigate the hematologic and in vivo immunologic effects of leukapheresis of from 2 X 10(9) to 1.6 X 10(10) peripheral blood lymphocytes from 9 cancer patients and 13 normal donors on the blood cell separator. The same parameters were measured in 10 individuals who did not undergo leukapheresis and 4 individuals who underwent sham leukapheresis. Studies were performed immediately prior to and following leukapheresis and at 4 hours, 1 day, 3 days, and 7 days following leukapheresis. There was a transient decline in blood lymphocyte pool (BLP) of the normal donors which returned to preleukapheresis values within 72 hours. Six of 13 normal donors and 2 of 9 cancer patients had a fall in blood lymphocyte count which was below the lower limit of the range of change in control donors immediately following leukapheresis, but all returned to control range within 24 hours. Five cancer patients had increases in lymphocyte count. DNCB reactivity and delayed cutaneous hypersensitivity reactions to common recall antigens were performed 2 weeks before, immediately before, and after leukapheresis, at 7 days and at 4 to 6 weeks following leukapheresis. There were no differences in skin test reactivity between groups. No clinical exacerbations of malignant disease occurred which might be construed to be due to leukapheresis.
Nonlinear Response of Parametrically-Excited MEMS (2005)

Due to the position-dependent nature of electrostatic forces, many microelectromechanical (MEM) oscillators inherently feature parametric excitation. This work considers the nonlinear response of one such oscillator, which is electrostatically actuated via non-interdigitated comb drives. Unlike other parametrically-excited systems, which feature only linear parametric excitation in their equation of motion, the oscillator in question here exhibits parametric excitation in both its linear and nonlinear terms. This complication proves to significantly enrich the system’s dynamics. Amongst the interesting consequences is the fact that the system’s nonlinear response proves to be qualitatively dependent on the system’s excitation amplitude. This paper includes an introduction to the equation of motion of interest, a brief, yet systematic, analysis of the equation’s nonlinear response, and experimental evidence of the predicted behavior as measured from an actual MEM oscillator.
Autotransfusion in Trauma. A Pragmatic Analysis (1985)

Department of Surgery, Denver General Hospital and the University of Colorado Health Sciences Center, Denver, Colorado
New approach to mask and wafer performance optimization for system-on-a-chip (SOC) devices (2000)

Detection of reticle CD errors appears to be one of the most critical challenges for low-k1 lithography, where CD accuracy, as mean-to-normal and mask error factor determine most of wafer CD budget. Measurements of reticle CDs are always a difficult process, as the mask manufacturer need to know the critical areas on the masks where he has to execute the measurements. This information is not generally available and if it is available, the number of measurements can be extremely large, in particular for system-on-a-chip devices with multiple critical number of measurements can be extremely large, in particular for system-on-a-chip devices with multiple critical areas resulting from the multiple electrical functions located on a chip. For these reasons, it becomes extremely interesting to execute the reticle CD metrology in a 'two-step' approach: first, detection of 'global' CD errors during the reticle inspection, followed by the second step, where the CD measurements will be executed only in those areas where the global CD error algorithm has detected errors large enough to affect wafer CD control. In this way, the among of CD measurements will be reduced to a manageable number and more important, measurements will be executed only in those area that have large errors. However, there is one critical concern in this approach, that is the capability of the 'global CD error' algorithm to accurately detect CD errors in areas with various chrome density as well as to detect CD errors of minimum 20 to 30nm which represent the specification of a good reticle for low-k1 lithography. In this paper, we report on a layout design with programmed CD errors and on the first result of applying the global CD error algorithm to detect these errors. The layout with programmed CD errors, is a multi-die per reticle case with several levels of CD errors, from global shifts in mean CD, to errors programed in a regular or in a random array inside the reticle active area. This design stresses the measurement algorithm as the programmed CD errors are combined with chrome density varying across the die, by a factor of 1 to 2.5X. One of the useful features of the proposed algorithm, detection of large CD fingerprint errors on the reticle, has been demonstrated in this work.
Design of a Passive Ankle Prosthesis With Energy Return That Increases With Increasing Walking Velocity (2017)

An estimated 623,000 individuals are living with a major lower leg amputation in the United States [1]. Of these amputations, 78% were due to peripheral vascular disease (PVD) and 45% were due to PVD in individuals with type I or II diabetes [2]. With diabetes and PVD incidence levels on the rise [1] and those in a depressed socio-economic situation more susceptible to develop type II diabetes [3], the demand for affordable, high quality ankle prostheses has never been higher. Prostheses currently available on the market include both passive and active devices, neither of which fully satisfies user requirements. Passive prostheses, the more commonly prescribed style, are economically priced but lack the powered push-off observed in a natural ankle [4] due to the absence of an actuator. As a result, passive prostheses cause a multitude of quality of life detriments to the end user including asymmetrical gait (for unilateral amputees), slower self-selected walking speeds, higher metabolic cost per distance traveled and increased pain in the residual limb [5–6]. Conversely, active devices can nearly match the functionality and powered push-off of a natural ankle [7] but are cost prohibitive. Among active devices, one of the most successful models is the BiOM. Initially developed at MIT, the BiOM uses an actuator in series with a spring to achieve near natural ankle behavior. In 2013, two years after the product’s official launch, the device cost approximately $50,000 and had only sold about 1,000 units [7]. The limitations of currently available ankle prostheses motivates work on a new solution, the EaSY-Walk (Early Stance Y-deflection), a passive ankle device that mimics several key aspects of a natural ankle joint, especially nonlinear rotational stiffness and rotational work output (powered push-off) that increases with walking velocity while remaining relatively inexpensive.
Hypothetical metallic allotrope of carbon (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHypothetical metallic allotrope of carbonRoald Hoffmann, Timothy Hughbanks, Miklos Kertesz, and Peter H. BirdCite this: J. Am. Chem. Soc. 1983, 105, 14, 4831–4832Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/ja00352a049https://doi.org/10.1021/ja00352a049research-articleACS PublicationsRequest reuse permissionsArticle Views744Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts