gebhart/patrepeval huggingface dataset:
Cellular and Molecular Mechanisms Involved in the Action of Vitamin D Analogs Targeting Vitiligo Depigmentation (2008)

The active metabolite of vitamin D3 - 1,25-(OH)2D3 - exerts most of its physiological and pharmacological actions through its nuclear receptor (VDR), regulating the transcriptional machinery of a variety of cell types. Basic research motivated by the detection of VDR in numerous target cells, has indicated potential therapeutic applications of VDR ligands in osteoporosis, cancer, secondary hyperparathyroidism and autoimmune diseases such as psoriasis, systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes and multiple sclerosis. In recent years vitamin D analogs, particularly calcipotriol and tacalcitol, have been used as topical therapeutic agents in vitiligo, an autoimmune pigmentary disorder characterized by aberrant loss of functional melanocytes from involved epidermis. The presence of cytotoxic T cells targeting melanocyte antigens and imbalance of the cytokine network were described as characteristics of the disease, eventually leading to melanocyte damage and death. Vitamin D ligands are designed to target the local immune response in vitiligo, acting on specific T cell activation, mainly by inhibiting the transition of T cells from early to late G1 phase and by inhibiting the expression of several pro-inflammatory cytokines genes, such as those encoding tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma). Vitamin D(3) compounds are known to influence melanocyte maturation and differentiation and also to up-regulate melanogenesis through pathways activated by specific ligand receptors, such as endothelin receptor and c-kit. In this review we summarize the complex pathogenetic rationale of vitamin D analogs in vitiligo depigmentation. Understanding the cellular and molecular mechanisms through which vitamin D targets the epidermal melanin unit is of great interest for identification of new effective therapeutic combination(s) that might induce repigmentation in vitiligo.
Novel design, optimization and realization of axial flux motor for implantable blood pump (2010)

This paper describes the novel design and optimization of an axial flux motor for blood pump application. With the design objective of maximizing the motor efficiency, different topologies of AFPM machine has been examined. Halbach arrangement of rotor magnets and use of Soft Magnetic Composite (SMC) material for the stator core adds further advantages to the optimal motor design. The results of the 3D Finite element analysis for the novel motor have been shown.
Application of TIDEDA to Water Resource Management (1989)

TIDEDA is a hydrological data handling system which has been developed to meet the needs of water managers and researchers. It provides a powerful linkage between data collection and data use and also supports real-time applications.
Application based brokering algorithm for optimal resource provisioning in multiple heterogeneous clouds (2015)

In recent years, adoption of cloud computing for computational needs is growing significantly due to various factors such as no upfront cost and access to latest service. In general, cloud infrastructure providers offer a wide range of services with different pricing models, instance types and a host of value-added features. Efficient selection of cloud services constitutes significant management challenges for cloud consumer, which is tedious and involves large information processing. To overcome this, the cloud brokers provide resource provisioning options that ease the task of choosing the best services based on consumers requirements and also provide a uniform management interface to access cloud services. This paper proposes a novel cloud brokering architecture that provides an optimal deployment plan for placement of virtual resources in multiple clouds. The objective of the deployment plan is to select the best cloud services with optimal cost, taking into account various attributes defined in service measurement index (SMI) with additional physical and logical constraints. The proposed cloud brokering architecture has been modeled using mixed integer programming formulation and Benders decomposition algorithm to solve efficiently. Efficacy of the proposed algorithm has been verified by extensive numerical studies and sensitivity analysis.
A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee. (2004)

Intraarticular HA treatment was significantly more effective than saline vehicle in mild to moderate OA of the knee for the 13 week postinjection period of the study.
Fast gradient-aware upsampling for cartoon video (2010)

In this paper, we propose a novel fast gradient-aware upsampling approach for cartoon animation. The advantage of our method is that we don't need any prior knowledge and deconvolution stage to deblur the estimated result like existing methods. The low-resolution input video is initially upsampled to the desired high-resolution by a fast bicubic interpolation approach. After that, the gradient transformation is applied to the initially upsampled video frame. Finally, energy optimization is employed to recover additional fine details and structures. Our method is easy to implement and runs very fast. Moreover, in order to increase or decrease the sharpness of the reconstructed high resolution image, the user just needs to adjust one parameterg . Thus, our approach is suitable for the task of cartoon video upsampling.
[Structure modification of triptolide, a diterpenoid from Tripterygium wilfordii]. (1992)

In this paper, the structure modification of triptolide was studied and nine triptolide derivatives were synthesized. A preliminary test for the immunosuppression activity in vitro showed that tripchlorolide (2) and tripbromolide (3) have strong activity similar to triptolide, while their toxicity are much lower. The activity of other compounds was decreased significantly. A simple method for the preparation of tripchlorolide from triptolide in 92% yield was found by reacting triptolide with HCl in acetone under mild condition.
Mechanism of the Penning Discharge at Low Pressures (1962)

Experiments have been conducted with a cold cathode Penning discharge in which the sputtering patterns, the direction of ion motion, the energy distribution of the ions, and the E×B electron rotation were studied. It is concluded that below 10−4 mm Hg the discharge consists essentially of a pronounced, rotating plasma sheath close to the anode, while most of the center portion of the discharge is depressed to near-cathode potential. At 3000 v and 2500 gauss, an average rotation frequency of the sheath of 70 Mc has been observed. This corresponds to an average field strength in the sheath of 8800 v/cm. An approximate computation indicates that in the presence of fields of this magnitude, classical cross-field mobility can well account for the anode currents observed. This result differs from the findings of Backus and of Chen and Bingham at higher pressures, where random-field-enhanced diffusion according to Bohm had to be postulated to explain the large anode currents.
Figure control for a fully segmented telescope mirror (1982)

A system is described to control the figure of a large telescope primary mirror that is composed of many individual segments. The geometry considered, employing hexagonal mirrors, allows a simple and economical control system. The system is shown to be reliable and effective in continuously maintaining the figure to the precision required for optical astronomy.
Subcortical Vascular Disease and Functional Decline: A 6‐Year Predictor Study (2002)

These findings suggest that cognitive impairments are most likely to have an effect on IADL function, because the skills involved are complex and involve integrative activity, whereas physical and cognitive impairments combined are likely to compromise ADL function, given the more basic and physical nature of the functions involved. These findings indicate that in people with SVD, both ADL and IADL status should be monitored, because, for many, decline in function over time is likely, and thus the provision of appropriate support required.
Bone Metastases in Metastatic Renal Cell Carcinoma: Now We Know That Cabozantinib Targets Bone Microenvironment (2018)

The multiple tyrosine kinases inhibitor cabozantinib has shown improvements in progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) in comparison to everolimus in patients with metastatic renal cell carcinoma (mRCC) in the METEOR trial, a phase III, randomized, open-label trial [1,2], leading to its approval in mRCC patients previously treated with antiangiogenic agents.
Object Geolocation Using MRF Based Multi-Sensor Fusion (2018)

Abundant image and sensory data collected over the last decades represents an invaluable source of information for cataloging and monitoring of the environment. Fusion of heterogeneous data sources is a challenging but promising tool to efficiently leverage such information. In this work we propose a pipeline for automatic detection and geolocation of recurring stationary objects deployed on fusion scenario of street level imagery and LiDAR point cloud data. The objects are geolocated coherently using a fusion procedure formalized as a Markov random field problem. This allows us to efficiently combine information from object segmentation, triangulation, monocular depth estimation and position matching with LiDAR data. The proposed fusion approach produces object mappings robust to scenes reporting multiple object instances. We introduce a new challenging dataset of over 200 traffic lights in Dublin city centre and demonstrate high performance of the proposed methodology and its capacity to perform multi -sensor data fusion.
An Optimal Constrained Pruning Strategy for Decision Trees (2008)

This paper is concerned with the optimal constrained pruning of decision trees. We present a novel 0–1 programming model for pruning the tree to minimize some general penalty function based on the resulting leaf nodes, and show that this model possesses a totally unimodular structure that enables it to be solved as a shortest-path problem on an acyclic graph. Moreover, we prove that this problem can be solved in strongly polynomial time while incorporating an additional constraint on the number of residual leaf nodes. Furthermore, the framework of the proposed modeling approach renders it suitable to accommodate different (multiple) objective functions and side-constraints, and we identify various such modeling options that can be applied in practice. The developed methodology is illustrated using a numerical example to provide insights, and some computational results are presented to demonstrate the efficacy of solving generically constrained problems of this type. We also apply this technique to a large-scale transportation analysis and simulation system (TRANSIMS), and present related computational results using real data to exhibit the flexibility and effectiveness of the proposed approach.
Regulation of Dopamine Transporter by Phosphorylation and Impact on Cocaine Action (2000)

The dopamine transporter (DAT) is the primary mechanism by which extracellular dopamine is cleared from the synaptic space. As such, it performs a key role in terminating synaptic transmission and in regulating the concentration of dopamine available for binding to presynaptic and postsynaptic dopamine receptors. DAT is also a major site of action for psychostimulants such as cocaine and amphetamine, and is believed to be involved with the reinforcing properties of these drugs. It has recently been found that activation of protein kinase C leads to reductions in dopamine transport and concomitant phosphorylation of DATs, suggesting that the protein undergoes functional regulation by phosphorylation. Other kinases may function similarly, providing neurons with a mechanism for fine temporal and spatial control of extracellular dopamine concentrations and subsequent neural activity. Therefore, phosphorylation of DAT has the potential to profoundly influence dopaminergic neurophysiology and may be related to mechanisms of cocaine abuse.
LABORATORY PRODUCTION AND 14C-LABELLING OF VIOMYCIN (1972)

Conditions established for viomycin production by Streptomyces griseus var. purpureus in 1-litre flasks were found suitable for production in a 14-litre fermentor, provided that shearing forces were reduced by the use of low initial aeration rates and low agitation rates. The optimum temperature for production was 30°C, no antibiotic being produced at 37°C. 14C-Arginine, and especially 14C-glucose, were satisfactory precursors of 14C-viomycin of moderate specific activity if added 40 hours afer the start of the fermentation. A variety of 14C-amino acids were unsuitable for isotopic labelling since their metabolism led to the release of large amounts of 14CO2. 14C-Acetate also was unsuitable for labelling purposes. Viomycin production was complex, the initial production being associated with sporulation and a secondary production being associated with spore germination and subsequent mycelial growth.
Tetra-O-methylscutellarein in Orange Peel (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetra-O-methylscutellarein in Orange PeelLyle James SwiftCite this: J. Org. Chem. 1965, 30, 6, 2079–2080Publication Date (Print):June 1, 1965Publication History Published online1 May 2002Published inissue 1 June 1965https://pubs.acs.org/doi/10.1021/jo01017a524https://doi.org/10.1021/jo01017a524research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Construction of Otherwise Isogenic Serotype 6B, 7F, 14, and 19F Capsular Variants of <i>Streptococcus pneumoniae</i> Strain TIGR4 (2003)

The polysaccharide capsule is the primary virulence factor in Streptococcus pneumoniae. There are at least 90 serotypes of S. pneumoniae, identified based on the immunogenicity of different capsular sugars. The aim of this study was to construct pneumococcal strains that are isogenic except for capsular type. Serotype 4 strain TIGR4 was rendered unencapsulated by recombinational replacement of the capsular polysaccharide synthesis (cps) locus with the bicistronic Janus cassette (C. K. Sung, J. P. Claverys, and D. A. Morrison, Appl. Environ. Microbiol. 67:5190-5196, 2001). In subsequent transformation with chromosomal DNA, the cassette was replaced by the cps locus derived from a strain of a different serotype, either 6B, 7F, 14, or 19F. To minimize the risk of uncontrolled recombinational replacements in loci other than cps, the TIGRcps::Janus strain was "backcross" transformed three times with chromosomal DNA of subsequently constructed capsular type transformants. Capsular serotypes were confirmed in all new capsule variants by the Quellung reaction. Restriction fragment length polymorphism (RFLP) analysis of the cps locus confirmed the integrity of the cps region transformed into the TIGR strain, and RFLP of the flanking regions confirmed their identities with the corresponding regions of the recipient. Transformants had in vitro growth rates greater than or equal to that of TIGR4. All four strains were able to colonize C57BL/6 mice (female, 6 weeks old) for at least 7 days when mice were intranasally inoculated with 6 x 10(6) to 8 x 10(6) CFU. The constructed capsular variants of TIGR4 are suitable for use in studies on the role of S. pneumoniae capsular polysaccharide in immunity, colonization, and pathogenesis.
DESCRIPTIVE SET THEORY (1996)

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Physical Meteorology (1955)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation John C. Johnson, H. J. aufm Kampe; Physical Meteorology. Am. J. Phys. 1 January 1955; 23 (1): 75–76. https://doi.org/10.1119/1.1933898 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
El RGPD, la gestión de riesgos y su fusión en la organización (2018)

El proyecto de adaptacion al RPGD debe basarse en el principio del riesgo y el perfecto entendimiento del ciclo de vida del dato en la organizacion para una fusion completa en los procesos horizontales y transversales de la organizacion.
Synthetic Minerals for Electronic Applications (2008)

Several of the mineral phases used for our common use are available in nature. However the purity of the natural mineral phases, their consistency of properties, structure, morphology and availability make them unsuitable for large scale continuous use in electronic and other applications. Therefore several inorganic minerals are synthesized to tailor their properties for specific applications. These minerals, though similar in their structural characteristics to the naturally occurring minerals, gives flexibility in controlling their purity, and crystallographic characteristics. This in turn helps to develop newer and improved applications like electronic and magnetic devices for communication. This article has concentrated on of some of the major synthetic materials used for electronic applications with special ephasis on their mineralogical aspects, structure, preparation and uses. The minerals covered include: quartz, synthetic Berlinite, synthetic Perovskites, synthetic halites, synthetic pyrites, synthetic rutiles, synthetic pyrochlores, synthetic spinels, synthetic sphalerites, synthetic wurtzites, synthetic corundum.
Dentin Regeneration in Vital Pulp Therapy: Design Principales (2001)

The nature and specificity of the mechanisms by which the amputated dentin-pulp interface is therapeutically healed determine the properties of the barrier at this site and play a critical role in the outcome of vital pulp therapy. Healing of the dentin-pulp complex proceeds either by natural repair-which results in defensive hard-tissue formation, or therapeutically regulated dentin regeneration, which aims to reconstitute the normal tissue architecture at the pulp periphery. Progress in biomedical research opens new directions for the design of biologically effective pulp therapies. Application of biocompatible and biodegradable carrier vehicles for local delivery of signaling molecules in pulp-capping situations showed induction of fibrodentin/reparative dentin formation, but often at the expense of underlying pulp tissue. An alternative pre-clinical model aiming to reconstitute normal tissue architecture directly at the dentin-pulp interface should be designed on the basis of the direct induction of odontoblast-like cell differentiation and reparative dentin formation at the pulp-capping material interface. Experimental data clearly showed that pulpal cells can differentiate directly into odontoblast-like cells in association with specific extracellular matrices (dentinal or fibrodentinal matrix) or TGF beta 1-containing artificial substrates. Dentin-induced dentinogenesis can be used as a master plan for the achievement of new therapeutic opportunities. In the present study, several short-term experimental studies on dog teeth for potential direct induction of odontoblast-like cell differentiation at the surface of rhTGF beta 1-containing artificial substrates (Millipore filters, hydroxyapatite granules, calcium hydroxide, pure titanium) failed to induce any specific reparative dentinogenic effects.
Fast Mode Decision for Intra-only H.264/AVC Coding (2006)

In this paper, we propose an efficient mode decision algorithm for intra-only H.264/AVC video coding. We exploit the correlation between optimal coding mode decisions of temporally adjacent pictures to reduce the computational efficiency of the encoding. Compared to the RD optimized mode decision algorithm in JM10.1, the proposed algorithm can reduce the computational complexity up to 33 % with negligible loss of compression efficiency (less-than 0.2dB).
Electron spin resonance detection of extracellular superoxide anion released by cultured endothelial cells (1998)

An ESR adduct DMPO-OH detected in the supernatant of BAEC after stimulation with the calcium ionophore A23187 originated from the trapping of extracellular O2-*, because coincubation with superoxide dismutase (30 U/ml) completely suppressed the ESR signal, whereas catalase (2000 U/ml) had no effect. A23187 stimulated extracellular O2-* production in a time- and dose-dependent manner. The coenzymes NADH and NADPH both increased the ESR signal, whereas a flavin antagonist, diphenylene iodonium, abolished the ESR signal. Phorbol myristate acetate potentiated, whereas bisindolylmaleimide I inhibited the A23187-stimulated O2-* production, suggesting the involvement of protein kinase C. These signals were not altered L-NAME, a NO-synthase inhibitor, suggesting that the endogenous production of NO* did not alter O2-* production. Finally, the amount of O2-* generated by A23187-stimulated post-confluent BAEC was one order of magnitude higher than that evoked by rat aortic smooth muscle cells stimulated under the same conditions.
New Terahertz Beam Imaging Device (1996)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text X. -C. Zhang and Q. Wu, "New Terahertz Beam Imaging Device," Optics & Photonics News 7(12), 9-10 (1996) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article