gebhart/patrepeval huggingface dataset:
PULMONARY HEMORRHAGE AS A CAUSE OF DEATH IN ALLOGENEIC BONE MARROW RECIPIENTS WITH SEVERE ACUTE GRAFT-VERSUS-HOST DISEASE (1994)

Acute graft-versus-host disease (GVHD) has recently been associated with endothelial cell injury. The potential clinical significance was explored here in an autopsy review. Thirty-seven allogeneic bone marrow recipients were identified in the autopsy files at The Johns Hopkins Hospital with no evidence of systemic infection. Forty-one percent (15/37) of these patients were found to have extensive recent pulmonary hemorrhage at autopsy which was thought to have led to terminal respiratory failure and death. The 37 patients were divided into 2 groups: those with significant acute GVHD (stage 2 or greater) and those without GVHD (stage 0 or 1). Fifty-nine percent (10/17) of the patients with significant acute GVHD died of acute respiratory failure due to recent pulmonary hemorrhage as opposed to 25% (5/20) of those without acute GVHD (P = 0.032, Fisher's exact test). Terminal pulmonary hemorrhage was also associated with preparation for BMT, with 67% (12/18) of those prepared with total body irradiation (TBI) having pulmonary hemorrhage as opposed to 15% (3/19) of those prepared with chemotherapy using Busulphan (P = 0.002). There was no significant difference in posttransplant survival, engraftment, or final platelet count between the patients stratified by GVHD or preparative protocol. The data support a strong association between significant acute GVHD and terminal hemorrhage, as well a possible association between TBI and pulmonary hemorrhage. Analysis of variance demonstrates that GVHD and TBI are independently associated with increased pulmonary hemorrhage (P < 0.01 for GVHD, P < 0.001 for TBI). We propose that GVHD contributes to terminal pulmonary hemorrhage by injuring the endothelium. However, this association could also be a secondary effect, i.e., toxicity from therapy for GVHD, or an abnormality in cytokines or growth factors. The pathogenic relationship between significant GVHD and terminal hemorrhage is discussed briefly.
Effect of thermal placement techniques on some physical properties of gutta‐percha (1992)

Some clinical techniques for the placement of gutta-percha root fillings involve the application of heat. This study was undertaken to assess the effects of intracanal heating techniques on the following properties of gutta-percha: coefficient of thermal expansion, softening temperature, phase transition temperature and organic content. Samples from each of four products were prepared by three different methods. The materials were studied by thermomechanical analysis, simultaneous thermogravimetry and differential thermal analysis, and by measurement of weight loss on ashing. It was shown that the techniques of gutta-percha placement involving heating in the root canal caused reversible physical changes in the materials without any apparent change in chemical composition. The average coefficient of thermal expansion was 137 x 10(-6)/degrees C, the softening temperature was 55.5 degrees C, there were two characteristic phase changes, and the organic content was 25%.
Correlating phenotype and genotype in the periodic paralyses (2004)

Hypokalemic periodic paralysis, hyperkalemic periodic paralysis, and paramyotonia congenita may be distinguished based on clinical data. This series of 226 patients (127 kindreds) confirms some clinical features of this disorder with notable exceptions: In this series, patients without mutations had a less typical clinical presentation including an older age at onset, no changes in diet as a precipitant, and absence of vacuolar myopathy on muscle biopsy.
Importance of Age and Postimplantation Experience on Speech Perception Measures in Children With Sequential Bilateral Cochlear Implants (2007)

Sequential bilateral cochlear implantation in children of diverse ages has the potential to improve speech perception abilities in the second implanted ear and to provide access to the use of binaural mechanisms such as the head shadow effect. The improvement unfolds over time and continues to grow during the 6 to 12 months after activation of the second implant. Younger children in this study achieved higher open-set speech perception scores in the second ear, but older children still demonstrate bilateral benefit in noise. Determining the long-term impact and cost-effectiveness that results from such potential capabilities in bilaterally implanted children requires additional study with larger groups of subjects and more prolonged monitoring.
Recent Developments in Inspection Techniques for Corrosion Damaged Concrete Structures (1992)

Improved procedures for inspecting both reinforced concrete and prestressed concrete structures, with regard to determination of the embedded steel components are discussed. Prototype ultrasonic procedures recently developed to determine the condition of prestressed pretensioned tendons in concrete will be discussed. The application of electrochemical surface mounted systems for estimating the rate of corrosion of reinforcing steel and other embedded steel components in large concrete structures will also be described. In particular, the ability to obtain rate of corrosion data over the concrete surface and presenting it as iso-corrosion rate contours will be highlighted.
Thermal and Mechanical Properties of Plasma Sprayed ZrO2-CeO2-Y2O3 Coatings (1996)

Abstract Plasma sprayed ZrO2-CeO2 and ZrO2-CeO2-Y2O3 coatings were investigated to develop advanced thermal barrier coating (TBC) with improved thermal and mechanical properties. The addition of a large amount of CeO2 to ZrO2 decreased the thermal conductivity, but it also reduced the mechanical property like hardness. Addition of Y2O3 to ZrO2-CeO2 was effective to improve the hardness. Double layered coating composed of a low thermal conductive top layer, such as ZrO2-CeO2-Y2O3 and a high strength base layer like yttria stabilized zirconia was fabricated. It exhibited an excellent thermal shock resistance and high thermal barrier capability.
Locally monotonic regression (1993)

The concept of local monotonicity appears in the study of the set of root signals of the median filter and provides a measure of the smoothness of the signal. The median filter is a suboptimal smoother under this measure of smoothness, since a filter pass does necessarily yield a locally monotonic output; even if a locally monotonic output does result, there is no guarantee that it will possess other desirable properties such as optimal similarity to the original signal. Locally monotonic regression is a technique for the optimal smoothing of finite-length discrete real signals under such a criterion. A theoretical framework in which the existence of locally monotonic regression is proved and algorithms for their computation are given. Regression is considered as an approximation problem in R/sub n/, the criterion of approximation is derived from a semimetric, and the approximating set is the collection of signals sharing the property of being locally monotonic.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Zeolite-entrapped osmium carbonyl clusters: selective and stable catalysts for CO hydrogenation (1989)

[H2Os(CO)4] is converted in the pores of a basic form of zeolite Y (formed by treatment with NaN3)to give entrapped Os carbonyl clusters that catalyse CO hydrogenation at 573 K and 19 bar (1 bar = 105 Pa) to give C2—C4 hydrocarbons in high yield with only slow loss of catalytic activity and selectivity.
Decreased NADH-oxidoreductase activities as an early response in rat liver to the carcinogen 2-acetylaminofluorene. (1985)

Reduced nicotinamide adenine dinucleotide (NADH):ferricyanide reductase and DT-diaphorase specific activity in total homogenates of rat liver are markedly decreased as a very early biochemical event of hepatocarcinogenesis induced by the carcinogen 2-acetylaminofluorene (AAF). A 50 to 75% decrease in NADH:ferricyanide reductase was observed after 1 day of AAF (0.025% in the diet) feeding and persisted throughout a 7-week continuum of AAF administration. Carcinogen added directly to cell extracts had no effect. Similar results were obtained with single injections of either AAF or diethylnitrosamine. Xanthine dehydrogenase was also reduced in liver following AAF administration to nearly the same extent as NADH:ferricyanide reductase and DT-diaphorase. Total NADH-cytochrome c reductase and mitochondrial activity as estimated from succinic dehydrogenase were not affected by carcinogen administration relative to basal dietary controls. The reduced nicotinamide adenine dinucleotide phosphate:cytochrome c reductase that functions in drug detoxification was elevated. With livers of animals fed 4-acetamidophenol, a hepatotoxin chemically related to AAF, small decreases were noted in NADH:ferricyanide reductase, but not in xanthine dehydrogenase nor in DT-diaphorase. Initial lowering of these activities in the livers of the carcinogen-treated animals is preceded by or concomitant with a reduction in the levels of extramitochondrial pyridine nucleotides known from other studies to result from DNA damage.
High Aspect Ratio Package Core Production with Electrolytic Deposited Copper (2010)

A typical package core consists of copper clad dielectric which is drilled to produce the necessary through vias serving two functions either as electrical or as thermal conduits. The thermal vias are normally characterised by a low drill pitch and a localisation at the centre of the package core. The vias are plugged after metallisation with a resin material to give the core the required planar surface necessary to provide the basis for the subsequent build up layers. Use of electrolytic deposited copper has been introduced as a new method to fill such through vias, pure copper as a plugging material has obvious advantages due its higher thermal conductivity in comparison to any currently available plugging resins. Significant cost savings are also possible as a fully automated in line processing sequence is available for electrolytic copper deposition in comparison to the more labour intensive resin plugging methods. The package cores utilising this technology have however been restricted to a dielectric thickness in the range 60μm to 100μm and with through via diameter 75μm to 100μm due to limitations in the processing technology. With these dimensions a hole pitch of down to 250μm may be filled reliably and is currently in production, latest results from this technology are shown. Hole filling with higher aspect ratios and particularly with substrates thicker than 200μm has required improvements in processing to ensure uniform copper filling. This paper describes the optimised process for through hole filling and shows the results achieved with dielectric materials 200μm and up to 400μm thick. Current qualification results of substrate 400μm thick with through via 80μm diameter are shown together with the comparison of filling with via pitch variation between 1.0mm and 0.6mm
Abstract 4581: Implementation of a new cancer protein biomarker development pipeline - NCI's clinical proteomic technologies for cancer (2010)

Abstract Proteomic technologies have revolutionized the area of protein biomarker discovery by providing powerful new tools such as protein arrays and mass spectrometry to characterize complex proteomes, multi-protein complexes and post-translational modifications. However, attempts to use proteomic approaches to discover cancer biomarkers in biofluids and tissues have been largely unsuccessful in the past. This indicates issues present in the biomarker candidate pipeline mainly due to variability within biomarker discovery and the lack of verification (or pre-validation) of biomarkers prior to costly clinical validation studies using immunosorbent assay (ELISA). Clinical Proteomic Technologies for Cancer (CPTC) initiative established by NCI in 2006 sought to develop a more refined, efficient, and reliable biomarker development pipeline anticipated to produce better-credentialed candidate leads, ultimately accelerating the translation of new cancer biomarkers into diagnostic tests. CPTC is a team science based five-year initiative composed of three components with an emphasis on the optimization of technology platforms, standards development, involvement with the U.S. Food and Drug Administration, and community reagents and resources development to address the challenges of clinical proteomics and to enhance technical abilities to identify and measure proteins accurately, quantitatively and reproducibly in biological systems. This presentation highlights the significant milestones of this initiative in building a more reliable and efficient protein biomarker development pipeline - one that consists of three development stages that we believe places the field of proteomics as a key component in initiatives for personalized medicine - Discovery, Verification, and Validation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4581.
Research on Biosignal Control System with Eye Movement (2000)

We have designed a new biosignal control system that offers the disable the opportunity to control some electrical appliances. The biosignal control system is based on the signals derived from the forehead during eye movement, using five electrodes fixed on the forehead. The four directions of eye movement (up, down, left, and right) allow as four primary control signals. With selection of 2 signals from the four primary signals, we can get 16 different signals. And select 3 signals from the four primary signals, the 64 and 16 different types signal system can be developed. It all amounts to 84 control signals that can be obtained.
Single CdSe quantum dots for high-bandwidth single-photon generation (2003)

We have measured the correlation of the photon emission from single CdSe quantum dots under pulsed excitation. The results demonstrate that the emission from a single CdSe quantum dot can be used to generate single green photons on demand with subnanosecond accuracy.
Activation of human peripheral-blood-derived monocytes by cis-diamminedichloroplatinum: enhanced tumoricidal activity and secretion of tumor necrosis factor-alpha. (1992)

The anticancer agent cis-diamminedichloroplatinum (CDDP) has been shown to have immunopotentiating and immuno-suppressive properties depending on the CDDP concentration used. Treatment of human peripheral-blood-derived monocytes (PBM) in vitro with low concentrations of CDDP resulted in a significant potentiation of antitumor cytotoxicity as assessed in an 18-hour 51Cr release assay. The potentiation of cytotoxicity by CDDP was also observed with PBM treated with recombinant interferon-gamma (rIFN-gamma). The monocyte-mediated cytotoxicity was significantly inhibited when antitumor necrosis factor (TNF) antibody was added to the assay culture. The role of TNF in the cytotoxic mechanism was further corroborated by demonstrating that significant levels of immunoreactive TNF-alpha in the supernatants were detected by ELISA. Further, supernatants derived from CDDP-treated monocytes were cytotoxic to the TNF-sensitive tumor cells and the cytotoxicity was neutralized by the addition of anti-TNF antibody. The secretion of TNF-alpha by CDDP-treated monocytes was readily detected as early as 4 h after culture and was dependent on de novo protein synthesis as inhibitors of RNA and protein synthesis abolished TNF-alpha secretion. Altogether, these results demonstrate that CDDP can potentiate monocyte-mediated antitumor cytotoxicity and stimulates TNF-alpha synthesis and secretion.
Pseudo-address generation algorithm of packet destinations for Internet performance simulation (2002)

This paper investigates the stochastic property of the packet destinations and proposes an address generation algorithm which is applicable for describing various Internet access patterns. We assume that a stochastic process of Internet access satisfies the stationary condition and derive the fundamental structure of the address generation algorithm. The pseudo IP-address sequence generated from our algorithm gives dependable cache performance and reproduces the results obtained from trace-driven simulation. The proposed algorithm is applicable not only to the destination IP address but also to the destination URLs of packets, and is useful for simulation studies of Internet performance, Web caching, DNS, and so on.
Electron storage ring beam lifetime dependence on pressure and pumping speed (1984)

The beam loss in electron storage rings depends to a large extent on the interaction of the beam with heavier residual gas molecules such as CO, CO/sub 2/ and A due to Bremsstrahlung and Coulomb scattering. The gas density inside the vacuum chamber is determined by the surface condition of the vacuum chamber which is bombarded by photons (synchrotron radiation) generated by circulating electron beams and by the installed pumping. During the spring shutdown the x-ray ring vacuum system was updated and baked out. Residual gas spectra obtained were typical of a well baked out system, i.e., hydrogen constituted approx. 95% of the gas and the average pressure was in the 10/sup -10/ Torr range. During initial operation the composition of desorbed gases was 43% H/sub 2/, 25% CO and 16% CO/sub 2/ and CH/sub 4/. After 3 months of beam conditioning desorption dropped by a factor of 5 and the CO, CO/sub 2/ and CH/sub 4/ peaks represented smaller percentage of total desorbed gas. Beam lifetime did not, however, show a corresponding increase. The pumping speed of distributed pumps dropped to zero at 1 x 10/sup -9/ Torr pressure but increased rapidly from approx. 20l/s in low 10/sup -9/ as the pressure increased.
Cholecystokinin Antagonizes Opioid Function during Electroacupuncture Modulation of Reflex Hypertension in Rats (2012)

Hypertension is one of the greatest causes of death in middle‐aged and elderly North Americans, but current western medical therapies are not fully effective. Acupuncture or electroacupuncture (EA) is increasingly being accepted as a viable therapy in the United States and may serve as an alternative treatment to drug therapy in patients with mild to moderate hypertension. We have demonstrated that EA acts through an opioid mechanism in rostral ventrolateral medulla (rVLM) to inhibit sympathoexcitatory reflexes induced by gastric distention. Cholecystokinin octapeptide (CCK‐8), a gastrointestinal peptide hormone, is present throughout the central nervous system and mediates pain and anxiety. CCK‐8 interacts with CCK1 and CCK2 receptors. The present study investigated the hypothesis that CCK‐8 in the rVLM limits the modulatory action of EA effect on sympathoexcitatory responses. Experiments were performed on male rats anesthetized with ketamine and α‐chloralose who were subjected to repeated gastric distension every 10 minutes. EA ( 2Hz, 0.5ms, 1–4mA) at Jianshi‐Neiguan (P5–P6) acupoints was applied for 30 min followed by microinjection of CCK‐8 (0.15mM, 50 nl) into the rVLM in 7 rats reversed the EA modulatory response from (11.0 ± 2.0 ) to (19.1 ± 2.8) mmHg. Saline injections into the rVLM at the end of 30 min EA did not influence the prolonged inhibition of reflex elevations in blood pressure in five other animals. Alternatively, devazepide (0.5 mM, 50 nl), a CCK1 antagonist microinjected into the rVLM of six rats that initially did not respond to 30 min of EA led to conversion during a second application of EA. Micoinjection of the vehicle of devazepide (50 nl ) into rVLM did not modify the nonresponsiveness to EA application (n=2). These data suggest that CCK‐8 through its action on CCK1 receptors limits the action of EA in the rVLM of rats in modulating reflex hypertension. (Supported by AHA 10POST4190125, NIH HL‐63313 and HL‐072125).
The Polymerization of Vinyl Monomers in the Presence of Surface Active Agents. III. The Rate of the Polymerization of Styrene (1973)

Abstract Styrene polymerized in the presence of sodium tetrapropylenebenzenesulfonate in an aqueous system without any ordinary initiators. The rate of the polymerization was dependent on the concentration of the surfactant and on the initial monomer concentration. The apparent activation energy of the polymerization was about 13.9 kcal/mol. The polymerization was inhibited by adding hydroquinone to the reaction system.
Identification of an <scp>RNA</scp> element for specific coordination of A‐to‐I <scp>RNA</scp> editing on <scp>HTR</scp>2C pre‐mRNA (2015)

Adenosine-to-Inosine (A-to-I) RNA editing is an intracellular mechanism in which inosine is specifically substituted against adenosine by the action of adenosine deaminases acting on RNA (ADARs). Serotonin 2C receptor (HTR2C) is encoded through combinatorial A-to-I RNA editing at recoding sites (A - E site) on its pre-mRNA. Although the efficiency of RNA editing at particular sites is known to be critical for modulating the serotonin signaling, the mechanistic details of site-specific editing on HTR2C pre-mRNA are not fully understood. Toward complete understanding of this mechanism, we discovered an RNA element, which coordinates site-specific RNA editing on HTR2C pre-mRNA by an in vitro editing assay and secondary structural analysis of mutant HTR2C RNA fragments. Our results showed that HTR2C pre-mRNA forms a characteristic structure, which was restricted by the internal loop and Watson-Crick base-pair interaction on site E, for intrinsic editing. We suggest that the internal loop would contribute toward adjusting the relative distance and/or geometry between the editing sites and the scaffold for ADAR.
Electronic Effects on the Selectivity of Pd‐Catalyzed CN Bond‐Forming Reactions Using Biarylphosphine Ligands: The Competitive Roles of Amine Binding and Acidity (2007)

Elektronischer Einfluss: Die Korrelierung der Bindungskonstanten von Aminen an isoliertes [SPhosPd(Ph)Cl] mit dem pKS-Wert der Aminkomplexe zeigt, dass die Selektivität der katalytischen Arylierung von Aminen durch die elektronischen Eigenschaften des Amins beeinflusst wird. Die Selektivitäten von C-N-Kreuzkupplungen mit neutralen Aminen lassen sich durch Verwendung von Lithiumamiden umkehren. SPhos=2-Dicyclohexylphosphanyl-2′,6′-dimethoxy-1,1′-biphenyl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z702122_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
(App. Table II-11) Concentrations of chemical elements in aerosols collected on AFA-XA filters in the Norwegian, Greenland and Barents seas in July-August 1996 (2006)

(App. Table II-11) Concentrations of chemical elements in aerosols collected on AFA-XA filters in the Norwegian, Greenland and Barents seas in July-August 1996