gebhart/patrepeval huggingface dataset:
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection (2015)

Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using a murine model of recurrent S. aureus peritonitis, we demonstrated that prior exposure to S. aureus enhanced IFNγ responses upon subsequent infection, while adoptive transfer of S. aureus antigen-specific Th1 cells was protective in naïve mice. Translating these findings, we found that S. aureus antigen-specific Th1 cells were also significantly expanded during human S. aureus bloodstream infection (BSI). These Th1 cells were CD45RO+, indicative of a memory phenotype. Thus, exposure to S. aureus induces memory Th1 cells in mice and humans, identifying Th1 cells as potential S. aureus vaccine targets. Consequently, we developed a model vaccine comprising staphylococcal clumping factor A, which we demonstrate to be an effective human T cell antigen, combined with the Th1-driving adjuvant CpG. This novel Th1-inducing vaccine conferred significant protection during S. aureus infection in mice. This study notably advances our understanding of S. aureus cellular immunity, and demonstrates for the first time that a correlate of S. aureus protective immunity identified in mice may be relevant in humans.
The Reactions of Saturated Fatty Acid Esters with Hydrogen Peroxide (1960)

This research was carried out to find the kinds of compounds formed by the action of 30% H2O2 on saturated fatty acid esters.Methyl ester of palmitic-, lauric-, caprinic-, caprylic-, caproic-, valeric-, and butyric acid were reacted under various conditions, without catalyst.As the reaction products, lower mono- and di-carboxylic acids and lower carbonyl compounds were always recognised, and di-carboxylic acids were obtained with good yield, especially from lower fatty acid esters, under the condition of the mol ratio of methyl ester to hydrogen peroxide to be 1 : 11 or more, and over 30 hrs at the temperature of 95105°C.From the value of the fixed quantity of carbon dioxide that produced by these reactions, it was recognised that lower esters were more readily reactive than the higher homologue.
Conception of an integrated sensor for the radiation monitoring of the CMS experiment at the large hadron collider (2004)

The concept of an active integrated dosimetric sensor for the radiation monitoring of the Compact Muon Solenoid experiment at the CERN (European Center for Nuclear Research) Large Hadron Collider is presented. The sensor, based on RadFET, OSL, p-i-n diode, and pad detector dosimeters, will measure both ionizing and nonionizing energy losses in the harsh radiation environment produced by hadron interactions.
Shape-selective Raman scattering from surface phonon modes in aggregates of amorphous SiO2 nanoparticles (1997)

A spontaneous Raman scattering from the surface phonon modes (SPMs) of amorphous silica (SiO2) nanoparticles which is small compared with the excitation wavelength (514.5 nm) and aggregated in micron size clusters (globules) is utilized to determine the shape of particles. The excitation dynamics for these modes were studied for silica samples pretreated at different temperatures (30–1000 °C). The SPMs are located between Raman peaks corresponding to the bulk traverse-optical (TO) and longitudinal-optical (LO) asymmetrical and bending phonon modes. An anomalously large TO-LO splitting (∼185 cm−1) of bending modes was observed. The shape examination was based on the fact that three depolarization factors are equal in value for spherical nanoparticles, but they are different for an elliptical one. According to this, one can observe one or three SPMs, respectively. The position of corresponding Raman peaks allows one to determine the depolarization factors and subsequently the shape of nanoparticles. The single SPM is located between Raman peaks corresponding to the TO and LO asymmetrical phonon modes and can be attributed to small spherical particles. Six different SPMs, which are located between Raman peaks corresponding to the TO and LO bending phonon modes, were observed. These modes can be assigned to elliptical nanoparticles in two surrounding mediums of different effective dielectric constants. The intensity of these SPMs is decreased drastically by heat treatment at a temperature around 950 °C, suggesting that aggregates of nanoparticles form the bulk α-quartz structure. The bulk structure formation from small silica particles was supported by thermogravimetric measurements. The values of the fraction of the total sample volume occupied by particles were calculated theoretically. A good agreement with the theory was obtained by assuming the anomalously large TO-LO splitting of bending phonon modes in nanoparticles of the amorphous silica.
Ribozyme Targeting of Angiogenic Molecules (1999)

The importance of blood vessel formation (angiogenesis) for the local growth of solid tumors and their metastatic spread is well established (1,2). A large series of correlative clinical studies published by different groups over the past seven years showed that the number of blood vessels detected in a primary tumor is an independent prognostic indicator of the outcome of the disease and is directly related to the rate of metastasis of tumors of different origin, such as breast cancer (3–8),nonsmall-cell lung cancer (9), prostate cancer (10), squamous cell carcinoma of the head and neck (11),and melanoma (12,13). In general, these studies showed that the numbers of blood vessels in a given primary tumor specimen is indicative of the rate of metastasis of the respective tumor and gives an independent measure of the outcome of the disease. Of additional significance are reports that in breast cancer patients with estrogen receptor (ER)-positive tumors, and hence apparently good prognosis, high microvessel density in the primary tumors seems to predict poor clinical outcome (8).KeywordsMelanoma CellBasic Fibroblast Growth FactorHammerhead RibozymeAngiogenic MoleculeWM852 Melanoma CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The Wenckebach phenomenon in sino-atrial block. (1966)

Disturbances in conduction analogous to those occurring at the atrio-ventricular (A-V) node may be present at the sino-atrial (S-A) junction. When second degree block occurs at the S-A junction, it may adopt the form of the Wenckebach phenomenon. Early descriptions of this arrhythmia were presented by Wenckebach (1906), Rihl (1908), and Wenckebach and Winterberg (1914). There have been relatively few reports since. Barlow (1927), in a review of the subject, found 54 cases, and more recently, Greenwood and Finkelstein (1964), using rigid criteria in their selection, found that earlier reports comprised 219 unequivocal examples of all forms of S-A block of which 38 (17%) were of the Wenckebach type.
A graded magnetization single pole head for perpendicular recording (1995)

The magnetic field of a graded magnetization single pole head in the presence of a highly permeable magnetic underlayer is analyzed. Vertical field amplitudes and gradients in the region close to the trailing edge of the pole are shown to be higher than those produced by a conventional single pole. For a perpendicularly magnetized medium, output spectral response functions, roll-off curves and peak shift computations indicate improved replay performance. The exact theoretical solution is obtained in the form of an infinite series using Fourier analysis but it is shown that the leading term alone can lead to a simple and accurate approximation. New theoretical results are also presented for a constant potential pole, including a simple approximation to the field and explicit exact formulae for certain output calculations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Order of services at the ordination of Mr. Samuel Barrett, as pastor of the twelfth Congregational church. Boston, February 9, 1825. Boston: Printed at the office of W. W. Clapp. 1825. (1825)

Imprint 3.
Page Order: Leaflet
Available also through the Library of Congress web site in two forms: as facsimile page images and as full text in SGML.
Printed Ephemera Collection; Portfolio 53, Folder 24.
Operations analysis (study 2.1): Payload designs for space servicing (1974)

Potential modes of operating in space in the space shuttle era are documented. The October 1973 NASA Mission Model provides a definition of various NASA and non-DOD automated payload configurations when employed in an expendable mode. The model also specifies a launch schedule for initial deployment of payloads as well as for subsequent replacements at periodic cycles. This model and its associated payload definitions serve as a foundation for the data presented in this report. The reference model has been revised to reflect automated space servicing of payloads as an operational concept instead of the existing expendable approach. The indication is that the bulk of a payload's subsystems and mission equipment require no support over the lifetime of the program. However, failure of a single unit could result in loss of the mission objectives. When space servicing is employed, the approach is to replace only that unit causing the anomaly. This concept affords an opportunity to standardize space replacable units, as well as to reduce the expense of logistics support, by allowing multiple servicing on any single upper stage/shuttle flight.
OPG and Rankl Expression in Osteoblasts Grown on Different HA Ceramics (2007)

Hydroxyapatite (HA) ceramics is one of the most widely used bone substitute in clinics. Limited information is available concerning how HA ceramics may affect osteoprotegerin (OPG) and RANKL expression. In this study, osteoblastic-like SaOS-2 cells were grown on HA ceramics sintered at different temperature for 3 and 6 days, RANKL and OPG mRNA expression were analyzed with quantitative in situ hybridization (QISH) technique. Result showed that SaOS-2 grown on HA ceramics sintered at 800°C expressed higher RANKL mRNA than on other two HA ceramics after 3 days’ culture. No significant difference in OPG expression on different surfaces was detected after 3 days and 6 days culture. This result suggests that HA sintered at low temperature tend to induce more bone remodeling after implantation.
Synthese und Spaltung des 4‐Hydroxy‐ bzw. 4‐Methoxy‐6‐oxo‐6<i>H</i>‐1.2‐oxazin‐carbonsäure‐(3)‐methylesters (1964)

Abstract 4‐Hydroxy‐6‐oxo‐6 H ‐1.2‐oxazin‐carbonsäure‐(3)‐methylester (IIa), dargestellt durch Pyrolyse des α‐Oximino‐ß‐oxo‐glutarsäuredimethylesters, zerfällt durch Hydrolyse in Kohlendioxyd, Cyanwasserstoff und Malonsäure, während der 4‐Methoxy‐6‐oxo‐6 H ‐1.2‐oxazin‐carbonsäure‐(3)‐methylester (IIc) bei der Hydrolyse in ß‐Methoxy‐γ‐oxo‐glutaconsäure (IV) übergeht. — Die hydrierende Spaltung von II a führt zu α‐Amino‐ß‐oxo‐buttersäuremethylester, der sofort zu 3.6‐Dimethyl‐pyrazin‐dicarbonsäure‐(2.5)‐dimethylester kondensiert. Unter den gleichen Bedingungen wird II c zu α‐Amino‐ß‐methoxy‐glutarsäure hydrierend gespalten.
Developmental Changes in Apolipoprotein B Gene Expression in the Liver of Fetal Calves (1998)

Changes in apolipoprotein (apo B) gene expression in the liver were determined in fetal calves from 90 to 260 days of intrauterine life. Results were compared with those obtained from the livers of 1-month-old calves and adult cows. By Western blot analysis using a rabbit antiserum to bovine apo B, apo B100 was detected from 90 days of intrauterine life. Apo B100 was shown to be the only form of apo B detected in the liver of fetal calves whatever the gestational age indicating the lack of editing process during the prenatal period. Hepatic apo B contents were stable during intrauterine life and comparable to those of calves and lower than those of cows. Hepatic contents of apo B mRNA increased with the gestational age similarly to total RNA. Values of apo B mRNA at 260 days of intrauterine life were comparable to those in the liver of 1-month-old calves and adult cows. These results suggested that hepatic synthesis of calf apo B during fetal development is specifically regulated at a posttranscriptional level, either by a decrease in the rate of translation and/or by an increase in the rate of intracellular apo B degradation.
Osteoporosis-Summary of the 19th Steenbock Symposium (1989)

Dr. Wardlaw is an Assistant Professor of Medical Dietetics in the School of Allied Medical Professions, The Ohio State University, Columbus, Ohio. He received his Ph.D. from Iowa State University. His research currently is looking at how diet affects both serum lipids in men and bone density in women. Dr. harden is a Researcher in the Department of Medical Physics at the University of Wisconsin and a Scientist at Lunar Radiation Corporation. He received his Ph.D. from the 'University of Wisconsin and went on to a faculty position at the University of Illinois, Chicago. His research involves clinical and research applications of bone densitometry.
A design proposal of competency-based ePortfolio system utilizing Sakai OSP (2009)

Abstract: We have developed a Web-based portfolio system on Sakai CLE for supporting the students in
Use of Antidepressants and Risk of Cancer in Individuals Infected With HIV (2008)

Antidepressants, irrespective of their class, do not affect cancer risk in HIV-infected individuals.
NMR study of polymer miscibility in novolac-based positive electron resists (1995)

The success of NPR as an effective resist system for x-ray and electron beam lithography is critically dependent on the miscibility of the blend components. Solution and solid state NMR techniques are used in this investigation to gain a molecular level understanding of the factors controlling miscibility of the novolac and poly(2-methyl-l-pentene sulfone) (PMPS) in the NPR system. 2D-NOESY solution spectra of several novolacs and PMPS show interactions between the PMPS side chain and the novolac aromatic rings, suggesting that miscibility is related to these intermolecular interactions. Solid state cross-polarization magic-angle spinning (CPMAS) experiments show mixing of the blend components on the length scale of less than 200{Angstrom}.
Applications of Liquid Chromatography-Mass Spectrometry in Analytical Toxicology: A Review (1997)

Liquid chromatography-mass spectrometry (LC-MS), after long-term development that has introduced seven major interfacing techniques, is finally suitable for application in the field of analytical toxicology. Various compound classes can be analyzed, and sensitivities for more or less polar analytes that are as good as or better than those of gas chromatography-mass spectrometry can be obtained with modern interfaces. In addition, because ionization is often softer than classical electron impact, some LC-MS interfaces are able to handle fragile species that are otherwise not amenable to MS. This review is intended to present LC-MS to less familiarized readers and to give an extensive overview of the application of the different coupling techniques to doping agents, drugs of abuse, forensic analysis, toxic compounds of various nature, and several toxicologically relevant therapeutic drugs. Experimental parameters such as the interfaces used, ionization methods, detection limits, and experimental details for exemplary applications are given.
CIS: compound importance sampling method for protein–DNA binding site <i>p</i>-value estimation (2004)

The procedure for scanning DNA sequences and computing the statistical significance of putative binding site scores is available upon request at http://compbio.cs.huji.ac.il/CIS/ CONTACT: nir@cs.huji.ac.il.
The Role of Motion Analysis in Biomedical Engineering Education and Interdisciplinary Research (2013)

The purpose of this paper is to summarize current motion analysis techniques and described their role in biomedical engineering education as well as in interdisciplinary research. At the University of South Florida (USF), various methods of motion analysis are used for collaborative research in fields such as prosthetics, robotics, rehabilitation, and injury prevention. The motion analysis laboratory is also used in course work in a variety of fields promoting interdisciplinary exchanges among students and faculty.
Differential Effects of Prior Exposure to Environmental Mycobacteria on Vaccination with<i>Mycobacterium bovis</i>BCG or a Recombinant BCG Strain Expressing RD1 Antigens (2005)

In silico analysis reveals that most protective antigens expressed by the antituberculous vaccine Mycobacterium bovis BCG (BCG) are conserved in M. avium, supporting the hypothesis that exposure to environmental mycobacteria generates cross-reactive immune responses blocking BCG activity. We investigated the impact of sensitization with M. avium, M. scrofulaceum, or M. vaccae on the protective efficacy of a recombinant BCG strain expressing RD1 antigens (BCG::RD1), using a mouse model of experimental tuberculosis (TB). No evidence that the RD1-encoded antigens ESAT-6, CFP-10, and PPE68 were expressed by these environmental strains could be demonstrated by Western blot analysis. Mice sensitized with each of these strains did not prime cellular immune responses cross-reacting with the immunodominant ESAT-6. Importantly, clearance of BCG::RD1 from the lungs and spleens of mice exposed to each of the environmental strains before vaccination was minimal compared to that of BCG. In mice sensitized with M. avium, increased persistence of BCG::RD1 correlated with stronger antimycobacterial gamma interferon responses and enhanced protection against aerosol infection with M. tuberculosis, compared to BCG. In contrast, animals exposed to M. scrofulaceum or M. vaccae prior to vaccination with BCG or BCG::RD1 were better protected against TB than were the unsensitized controls. Our results suggest that the inhibitory effect of environmental mycobacteria on the protective efficacy of BCG depends critically on the extent of cross-recognition of antigens shared with the vaccine. In hosts sensitized with M. avium, potent immunogenicity of ESAT-6 and increased persistence of BCG::RD1 may allow this recombinant vaccine to overcome preexisting antimycobacterial responses.
HEADSPACE GAS CHROMATOGRAPHY AND SENSORY ANALYSES OF BUCKWHEAT STORED UNDER CONTROLLED ATMOSPHERE<sup>1</sup> (1999)

ABSTRACT The composition of volatile components in freshly‐milled buckwheat flour produced from seed stored under controlled atmospheres (97% N 2 1.5% O 2 and 1.5% CO 2 ) for 1 year was studied using capillary gas chromatography, mass spectrometry, sniffing port analysis, and sensory evaluation. Twenty‐five volatiles were identified from over 100 compounds removed from the flour by a novel dynamic headspace technique and separated by capillary gas chromatography. Eighteen odor‐active regions were detected but none were characteristic of the typical buckwheat flour aroma. The concentration of the major buckwheat volatiles decreased with storage of the seed under low O 2 and high CO 2 levels. The content of two of the odor‐active volatiles, hexyl acetate and 1‐hexanol, however, increased up to 4 fold in samples stored under controlled atmosphere for 60 weeks.
New trends in the reprocessing of spent nuclear fuel. Separation of minor actinides by solvent extraction (2016)

<p>Recycling of actinides from spent nuclear fuel by their selective separation followed by transmutation in fast reactors will optimize the use of natural uranium resources and minimize the long-term hazard from high-level nuclear waste. This paper describes solvent extraction processes recently developed, aimed at the separation of americium from lanthanide fission products as well as from curium present in the waste. Depicted are novel poly-N-heterocyclic ligands used as selective extractants of actinide ions from nitric acid solutions or as actinide-selective hydrophilic stripping agents.</p>
Change of Cyclic AMP Level in Synaptosomes from Cerebral Cortex; Increase by Adenosine Derivatives (1981)

The endogenous level of cyclic AMP in incubated synaptosomes from cerebral cortex of guinea pigs was investigated after the addition of various agents to the incubation medium. It appeared that the synaptosomal suspension already contained exogenous adenosine. Preincubation with theophylline or with adenosine deaminase (ADase) decreased both the exogenous level of adenosine and the intrasynaptosomal level of cyclic AMP. The level of cyclic AMP was reincreased by the addition of adenosine agonists, especially 2-chloroadenosine. This increase was antagonized by deoxyadenosine and was not inhibited by dipyridamole. These results suggest that the adenosine derivatives in the synaptic cleft regulate the level of cyclic AMP in nerve terminals through adenosine receptor on the presynaptic membrane. ADP, ATP, dopamine, and histamine also stimulate the formation of cyclic AMP in the ADase-treated synaptosomes.
1450: Role of Nitric Oxide in the Urinary Bladder Function: Effect of Argenine (2006)

You have accessJournal of UrologyModerated Poster, Wednesday, May 24, 2006, 8:00 - 10:00 am1 Apr 20061450: Role of Nitric Oxide in the Urinary Bladder Function: Effect of Argenine Catherine Whitbeck, Paul Chichester, Rebekah Sokol, and Robert M. Levin Catherine WhitbeckCatherine Whitbeck More articles by this author , Paul ChichesterPaul Chichester More articles by this author , Rebekah SokolRebekah Sokol More articles by this author , and Robert M. LevinRobert M. Levin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33654-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1450: Role of Nitric Oxide in the Urinary Bladder Function: Effect of Argenine." The Journal of Urology, 175(4S), p. 468 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 468 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Catherine Whitbeck More articles by this author Paul Chichester More articles by this author Rebekah Sokol More articles by this author Robert M. Levin More articles by this author Expand All Advertisement PDF DownloadLoading ...
ChemInform Abstract: TOTALSYNTH. VON SALUTARIDIN DURCH PHOTOLYSE (1971)

Abstract Das durch Bromierung von Isovanillin (I) erhältliche Bromderivat (II) wird zum 2‐Brom‐benzylisovanillin (III) umgesetzt und weiter über die Stufen (IV)‐(VI) in die Phenylessigsäure (VII) umgewandet.
In-Situ Observation of Au/TiO2 Catalyst in Oxygen-Gas Environments (2009)

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009
Estradiol 17 beta-hydroxysteroid dehydrogenase, a marker of breast cancer hormone dependency. (1985)

Intratumoral activity of the progesterone-dependent enzyme 17 beta-hydroxysteroid dehydrogenase (E2DH) was measured in 114 patients with breast cancer (33 pre- and 81 postmenopausal) before and/or after 8 days of a progestin treatment (lynestrenol, 10 mg/day). In 12 postmenopausal patients, the ability of E2DH to be stimulated by lynestrenol was compared to estradiol receptor (ER) and progesterone receptor (PR) levels. In premenopausal patients, E2DH was higher when tumors were excised in the luteal phase than when excised in the follicular phase. In postmenopausal patients, E2DH was higher after progestin treatment. However, E2DH stimulation by lynestrenol depended on receptor levels. It was most often markedly stimulated in ER-positive, PR-positive tumors. It remained low in ER-negative, PR-negative tumors. Intratumoral measurement of the progesterone-dependent enzyme E2DH in breast cancer after progestin treatment could therefore provide a fine and reliable index of the presence and functional character of PR and hormone dependency of the tumor.