gebhart/patrepeval huggingface dataset:
RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity (2016)

Plasmacytoid dendritic cells (pDCs) represent a unique immune cell type that responds to viral nucleic acids through the rapid production of type I interferons. Within the hematopoietic system, the transcription factor RUNX2 is exclusively expressed in pDCs and is required for their peripheral homeostasis. Here, we show that RUNX2 plays an essential role in promoting pDC localization and function. RUNX2 is required for the appropriate expression of the integrin-mediated adhesion machinery, as well as for the down-modulation of the chemokine receptor CXCR4, which allows pDC egress into the circulation. RUNX2 also facilitates the robust response to viral infection through the control of IRF7, the major regulator of type I interferon production. Mice lacking one copy of Runx2 have reduced numbers of peripheral pDCs and IFN-α expression, which might contribute to the reported difficulties of individuals with cleidocranial dysplasia, who are haploinsufficient for RUNX2, to clear viral infections.
RadioGatún, a belt-and-mill hash function. (2006)

We present an approach to design cryptographic hash functions that builds on and improves the one underlying the Panama hash function. We discuss the properties of the resulting hash functions that need to be investigated and give a concrete design called RadioGatun that is quite competitive with SHA-1 in terms of performance. We are busy performing an analysis of RadioGatun and present in this paper some preliminary results.
Atrial Programmed Pacing* (1978)

Early experience with a J-shaped lead inserted transvenously into the right atrial appendage is reviewed in thirty-one patients. Fifteen patients are still being followed with satisfactory atrial programmed pacing for five to ten years. A dislodgement rate of twenty percent led to the development of the "tined" J lead in the hope that better fixation would be achieved. Experimental data has shown the new lead to be stable with evidence in both animal and man of firm fixation of the lead in the appendage. The lead has been inserted in twenty patients. Of these, fifteen are still being followed with satisfactory atrial programmed pacing. There has been no case of dislodgement of the lead in a follow-up period of two years and eight months.
2P1-R14 Blade-Type Crawler Belt Mechanism for High-Speed Movement of Micro Unmanned Ground Vehicles in Rough Terrain(Wheeled Robot/Tracked Vehicle (3)) (2013)

Various devices, such as research robot or rescue robots, have been developed to reach locations where people cannot reach and to survey the conditions at those locations. Such devices need to have a high performance of over rough terrain, including high-speed movement and simple mechanics. They also need be easily controllable. In the past, researches focused on improving performance of over rough terrain at the expense of other features. In this paper, blade-type crawler belt mechanism performs over rough terrain without compromising the speed and controls. During the movement, the blades open outward, and the wheel diameter is effectively increased resulting in a higher performance. Furthermore, because the only modification is the addition of blades, the crawler belts move at a speed similar to ordinary crawler belts and require no additional changes. The proposed vehicle is tested and demonstrated its effectiveness through a laboratory experiment and field experiments.
A reexamination of the role of LYT-2-positive T cells in murine skin graft rejection. (1984)

We have investigated which T cell subclass defined by cytolysis with monoclonal anti-Lyt-1.2 and anti-Lyt-2.2 antibodies is required to adoptively transfer the ability to reject skin grafts. B6.Thy-1.1 spleen cells immune to graft antigens were fractionated with antibody plus C' and transferred to adult thymectomized, irradiated, bone marrow-reconstituted (ATXBM) B6.Thy-1.2 hosts that were simultaneously grafted with BALB.B skin. We found that when the ATXBM hosts were used 6 wk after irradiation and marrow reconstitution, both Lyt-1-depleted and Lyt-2-depleted immune spleen cells could transfer the ability to promptly reject skin grafts. However, such ATXBM recipients of Lyt-2-depleted cells that had rejected skin grafts were found to contain graft-specific CTL that were largely of host (B6.Thy-1.2) origin. When ATXBM hosts were used for the experiment 1 wk after irradiation and marrow reconstitution, no host-derived graft-specific CTL could be detected. However, graft rejection occurred in recipients of anti-Lyt-1- or anti-Lyt-2 plus C'-treated immune cells and specific CTL were generated from spleen cells of both groups. Thus, in the absence of a host-derived response, adoptively transferred immune Lyt-2+ cells, either resistant to, or that escaped from, antibody plus C' treatment, are able to expand in response to the antigenic stimulus provided by the graft. A more complete elimination of specific T cell subclasses is therefore needed to assess the relative contribution of a particular subset to the graft rejection process.
Relation between structure and function in some partially synthetic ribonucleases S'. II. Kinetic determinations on (Orn10, Glu11),(Orn10, Leu11)- and (Orn10, Lys11)-RNase S'. (1974)

The S-protein activating ability of [Orn10,Glu11]-, [Orn10,Leu11]- and [Orn10,Lys11]-S- peptide was tested, before and after guanidination, by exploring their capacity to regenerate ribonuclease activity when recombined with S-protein. The kinetic parameters Kmand k2of the resulting modified enzymes were also calculated using C > p and CpC as the substrates. In agreement with previous observations the results obtained indicate that the carboxamide function in position 11 is not essential for biological activity, but contributes by optimizing the RNase A catalytic activity.
Xanthene dyes in poly(vinyl alcohol) matrix with and without chromium(VI)/electron donor: kinetics of photobleaching (1994)

In our laboratories, we have performed many experimental investigations in order to characterize metal ion doped polymer materials, mainly Dichromated Poly(vinyl Alcohol) DC- PVA) and Dichromated Poly(acrylic acid) (DC-PAA), for their use in holography and nonlinear optics. These systems have been employed for recording volume transmission holograms and fabrication of holographic optical elements (HOEs). Moreover, they are attractive photosensitive materials because of their low cost, self-developing nature and high diffraction efficiency.
SP127EFFECTS OF CUMULATIVE ADMINISTRATION OF NIVOLUMAB ON RENAL INSUFFICIENCY (2018)

when the mother develops thrombocytopenia and signs of ADH overproduction. The severity and precocity of renal involvement is associated with higher morbidity and mortality attributable to prematurity but not with alterations in the subsequent child social/cognitive development. The possibility of distinguishing two types of preclampsia, with similar pathophysiology but different fetal prognosis requires further research.
Synthetic Studies on Biologically Active Alkaloids Starting from Lactam‐type Chiral Building Blocks (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Pressure distribution on Morton??s foot structure (1989)

The Morton foot structure (MFS) is a foot having, as its most prominent distinguishing feature, a second metatarsal head which is more distally placed than the head of the first. This structure has been associated with a variety of foot problems in athletes. The origin of these foot problems has been hypothesized to be an abnormal metatarsal head loading pattern found in the MFS. This study was conducted to determine whether the MFS produced a metatarsal head pressure profile which was different from the non-Morton foot. Plantar pressure distributions during walking were collected using a 1000 element piezoceramic pressure platform from the feet of 45 subjects (30 classified as having the MFS and 15 non-Morton or control subjects). The protrusion of the head of the second metatarsal beyond the first metatarsal head was determined by palpation and varied between 0.8 and 2.8 cm for the experimental group. Pressure distributions were collected from a mid-gait step onto the platform at a speed of 1.6 to 2 m.s-1 using a 15 m runway. Peak pressures and impulse values were determined for three forefoot regions. Results show that peak loading in both groups occurred under the second metatarsal but that the magnitudes of second metatarsal peak pressures were significantly higher in the MFS group (P less than 0.005). The results suggest that, although the loading pattern between MFS and normal feet is similar, the significantly higher second metatarsal head peak pressure in the MFS may predispose this foot type to problems associated with excessive localized pressure.
RHEED Rocking Curve Analysis of Si(111).RAD.3*.RAD.3-Ag Surface Phase Transition at Low Temperature (2006)

Si(111)√3×√3-Ag surface structural phase transition from honeycomb chained triangles (HCT) structure to inequivalent triangles (IET) structure is investigated using reflection high-energy electron diffraction (RHEED) rocking curves. Rocking curves are measured during spontaneous heating process of a cooled (∼120K) sample up to room temperature. The rocking curves were analyzed using many-beam dynamical RHEED calculations with three kinds of structural models, HCT (Ag triangle stays at mirror symmetry position), IET (Ag triangle rotates by 6 degrees) and rotating-HCT (r-HCT; Ag atoms are randomly rotating between ±6° which maintains the mirror symmetry) structures. At room and low temperatures, r-HCT and IET structures give the best results respectively. Rocking curves between room and low temperatures are also reproduced by mixing of r-HCT and IET structures and the mixing ratio changes almost linearly with substrate temperature. It is obtained that r-HCT coverage is almost 100 % at room temperature and IET coverage is about 60 % at 120 K. It is also found that mixing ratio of IET/r-HCT structure meets 0.5 at about 150 K which is known as a transition temperature in previous reports. [DOI: 10.1380/ejssnt.2006.414]
Free nerve endings in the ligamentum capitis femoris (2000)

We report the presence of free nerve endings (FNE) in the ligamentum capitis femoris (LCF). Qualitative and quantitative measurements on the incidence of FNE, as assessed by immuno-histochemistry for the S-100 protein, were obtained from 18 patients undergoing hip surgery. We found FNE in all LCF, with no association to age. The presence of FNE in the LCF suggests a role in noci-/proprioception of the hip.
OLIGOCLONAL EXPANSION OF CD8+ T-LYMPHOCYTES IN CULTURED PERIPHERAL LYMPHOCYTES DERIVED FROM ASYMPTOMATIC HTLV-I CARRIERS (1994)

Peripheral blood mononulear cells (PBMC) derived from 10 asymptomatic human T lymphotropic virus type I (HTLV-I) carriers were cultured for a short term (10-14 days) in the absence of exogenous antigens. In 5 carriers, when compared with 5 HTLV-I non-carriers an apparent increase in the proportion of CD8+ DR+ cells was observed. The clonality of cultured lymphocytes was then examined by analyzing the usage of Vbeta families of T cell receptor genes. In three of the 5 carriers with an increased CD8+ population, two to four Vbeta genes were dominant in the CD8+ population but not in the CD4+ population. No dominance of Vbeta gene usage was observed in lymphocytes derived from the 5 noncarriers. The sequence of cDNA from Vbeta families which were especially dominant revealed their oligoclonal characteristics. These results were quite similar to our previous findings from HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients in whom the same oligoclonal CD8+ cells were expanded cytotoxic T lymphocyte clones for HTLV-I genome products. We posed the question of whether the dominance of TCR Vbeta usage in cultured PBMC was associated with the HTLV-I genome dose in the PBMC or with anti-HTLV-I antibody titers. The three carriers who showed an increased CD8+ population mentioned above all showed a rather high HTLV-I genome dose, which again was similar to HAM/TSP patients. These three carriers however, did not necessarily show high anti-HTLV-I antibody titers in contrast with HAM/TSP patients, who generally do.
Medical and non‐medical barriers to outpatient treatment of fever and neutropenia in children with cancer (2006)

In only a minority of episodes can outpatient antibiotic management be implemented. Medical comorbidities and social barriers can make the transition to outpatient care difficult. However, initial hospitalization followed by oral antibiotic outpatient management appears safe and effective for low-risk patients who exhibit good responses to initial antibiotic therapy in hospital.
Ring-opening polymerization of strained metallocenophanes: a new route to high molecular weight poly(metallocenes) (1999)

Article Ring-opening polymerization of strained metallocenophanes: a new route to high molecular weight poly(metallocenes) was published on August 1, 1999 in the journal Pure and Applied Chemistry (volume 71, issue 8).
A Li10 Cage Containing the [C6H11P⋅⋅⋅–C(Ph)⋅⋅⋅–N]2− Ion: Umpolung in the Oligomerization of a Nitrile (2000)

Two types of anion are present in the lithium aggregate [{{[C6H11PC(Ph)N]Li2}{[H(PhCN)3(C6H11P)2]Li3}(thf)3}2]⋅2 C6H5CH3⋅2 THF obtained by the addition of C6H11PHLi to benzonitrile (PhCN), followed by deprotonation with nBuLi. In the trianion (right) the charge is located essentially in three distinct regions. The dianion (left) is the first example of this type to be structurally characterized.
Condensation of succinic anhydrides with Schiff bases. Scope and mechanism (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCondensation of succinic anhydrides with Schiff bases. Scope and mechanismNeal Castagnoli Jr. and Mark CushmanCite this: J. Org. Chem. 1971, 36, 22, 3404–3406Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://pubs.acs.org/doi/10.1021/jo00821a029https://doi.org/10.1021/jo00821a029research-articleACS PublicationsRequest reuse permissionsArticle Views578Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 3067: Regulation of PAX2 expression/activity by hypoxia and EGF in breast cancer cells (2012)

Abstract Breast cancer is the most common cancer in women and is associated with the highest mortality rate after lung cancer. The leading cause of deaths associated with this cancer is metastasis, but cellular and molecular mechanisms controlling the metastatic ability of breast cancer cells are only partially elucidated. There is direct and indirect evidence suggesting that PAX2, a transcription factor preferentially activated in breast cancer cells of the luminal subtype, could reduce the invasive and metastatic ability of these cells, by downregulating the expression of ERBB2. It is thus primordial to understand the mechanisms regulating the expression and activity of PAX2 in breast cancer cells. Specifically, because hypoxic conditions prevailing in the center of solid primary tumours are known to regulate the expression of many genes controlling invasion and metastasis, we are investigating the impact of hypoxia-mimicking agent cobalt chloride (CoCl2) on PAX2 expression in breast cancer cells. Similarly, because EGF growth factor regulates the expression and/or activity of many genes controlling invasion and metastasis, we are determining the impact of EGF exposure on PAX2 activation and/or gene expression in ER+ MCF-7 cell line. The identification of factors and mechanisms regulating the expression and activity of PAX2 in breast cancer cells will help understand the biology of this emerging factor in breast cancer cells and may provide multiple strategies to control invasion and metastasis of these cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3067. doi:1538-7445.AM2012-3067
Fisher transfer entropy: quantifying the gain in transient sensitivity (2015)

We introduce a novel measure, Fisher transfer entropy (FTE), which quantifies a gain in sensitivity to a control parameter of a state transition, in the context of another observable source. The new measure captures both transient and contextual qualities of transfer entropy and the sensitivity characteristics of Fisher information. FTE is exemplified for a ferromagnetic two-dimensional lattice Ising model with Glauber dynamics and is shown to diverge at the critical point.
Separation Analysis of Breast Cancer Progression Lines Using Contactless Dielectrophoresis (2011)

Selective separation and isolation of microparticles or cells based on their biophysical properties has become an essential step in laboratory use [1]. Techniques include field flow fractionation [2], fluorescent and magnetic activated cell sorting [3], laser tweezers [4] and dielectrophoresis [5]. The latter technique uses a particle’s intrinsic properties to its advantage without altering the original structure or disrupting the viability of the cell which is highly attractive for cancer research.
The Design of Phosphorylating Agents (1964)

Abstract Phosphorylating agents are compounds capable of transferring the group (HO) 2 P(O) in free or esterified form. Numerous phosphorylating agents can be classified into PXYZ systems, in which the element or group Z must be capable of accommodating the electrons of the PX bond. Systematic classification of PXYZ compounds and numerous examples of phosphorylation in chemistry and biochemistry are given.
Platelet endothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions (2001)

The functional importance of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) in platelets is unclear. Because PECAM-1 represents a newly assigned immunoglobulin-ITIM superfamily member expressed on the surface of platelets, it was hypothesized that it may play an important regulatory role in modulating ITAM-bearing receptors such as collagen (GP)VI receptor and FcgammaRIIA. To examine the functional role of PECAM-1 in regulating platelet-collagen interactions, 2 different approaches were applied using recombinant human PECAM-1-immunoglobulin chimeras and platelets derived from PECAM-1-deficient mice. Stimulation of platelets by collagen-, (GP)VI-selective agonist, collagen-related peptide (CRP)-, and PECAM-1-immunoglobulin chimera induced tyrosine phosphorylation of PECAM-1 in a time- and dose-dependent manner. Activation of PECAM-1 directly through the addition of soluble wild-type PECAM-1-immunoglobulin chimera, but not mutant K89A PECAM-1-immunoglobulin chimera that prevents homophilic binding, was found to inhibit collagen- and CRP-induced platelet aggregation. PECAM-1-deficient platelets displayed enhanced platelet aggregation and secretion responses on stimulation with collagen and CRP, though the response to thrombin was unaffected. Under conditions of flow, human platelet thrombus formation on a collagen matrix was reduced in a dose-dependent manner by human PECAM-1-immunoglobulin chimera. Platelets derived from PECAM-1-deficient mice form larger thrombi when perfused over a collagen matrix under flow at a shear rate of 1800 seconds(-1) compared to wild-type mice. Collectively, these results indicate that PECAM-1 serves as a physiological negative regulator of platelet-collagen interactions that may function to negatively limit growth of platelet thrombi on collagen surfaces.
Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue (2017)

// Eleonora Franzè 1 , Vicenzo Dinallo 1 , Angela Rizzo 1 , Martina Di Giovangiulio 1 , Gerolamo Bevivino 1 , Carmine Stolfi 1 , Flavio Caprioli 2 , Alfredo Colantoni 1 , Angela Ortenzi 1 , Antonio Di Grazia 1 , Giuseppe Sica 3 , Pier Paolo Sileri 3 , Piero Rossi 3 and Giovanni Monteleone 1 1 Department of Systems Medicine, University of Rome “TOR VERGATA”, Rome, Italy 2 Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy 3 Department of Surgery, University “TOR VERGATA” of Rome, Rome, Italy Correspondence to: Giovanni Monteleone, email: Gi.Monteleone@Med.uniroma2.it Keywords: IL-34; colorectal cancer; tumorigenesis; M-CSF-1; ERK 1/2 Received: July 29, 2017      Accepted: November 17, 2017      Published: December 15, 2017 ABSTRACT Interleukin-34 (IL-34), a cytokine produced by a wide range of cells, binds to the macrophage colony-stimulating factor receptor (M-CSFR-1) and receptor-type protein-tyrosine phosphatase zeta (PTP-z) and controls myeloid cell differentiation, proliferation and survival. various types of cancers over-express IL-34 but the role of the cytokine in colorectal cancer (CRC) remains unknown. We here investigated the expression and functional role of IL-34 in CRC. A more pronounced expression of IL-34 was seen in CRC samples as compared to matched normal/benign colonic samples and this occurred at both RNA and protein level. Immunohistochemical analysis of CRC tissue samples showed that both cancer cells and lamina propria mononuclear cells over-expressed IL-34. Additionally, CRC cells expressed both M-CSFR-1 and PTP-z, thus suggesting that CRC cells can be responsive to IL-34. Indeed, stimulation of DLD-1 cancer cells with IL-34, but not with MSCF1, enhanced the cell proliferation and cell invasion without affecting cell survival. Analysis of intracellular signals underlying the mitogenic effect of IL-34 revealed that the cytokine enhanced activation of ERK1/2 and pharmacologic inhibition of ERK1/2 abrogated IL-34-driven cell proliferation. Consistently, IL-34 knockdown in HT-29 cells with a specific IL-34 antisense oligonucleotide reduced ERK1/2 activation, cell proliferation and enhanced the susceptibility of cells to Oxaliplatin-induced death. This is the first study showing up-regulation of IL-34 in CRC and suggesting a role for this cytokine in colon tumorigenesis.
Uncommon dermoid cyst presented in the mandible possibly originating from embryonic epithelial remnants (2002)

A case of an intraosseous dermoid cyst that had developed in the mandible of a 29-year-old-male is reported. The patient was admitted to our dental clinic complaining of pain in the right molar area of the mandible. The patient had no particular history of the present illness. A radiographic examination revealed diffuse bone absorption in the right molar area. A biopsy showed the lesion to be an intraosseous dermoid cyst which was surgically enucleated. Microscopic examination of the excised tissue showed it to be well circumscribed with fibrous tissues, and the cystic space lined by keratinized epithelium. In addition, sweat glands and hair follicle-like skin appendages were identified in the cystic wall, where a daughter cyst was also found. We suggested that this uncommon cyst had developed in the mandible, as a result of embryonic epithelium migration. The patient remained in good health during the three year follow-up.