gebhart/patrepeval huggingface dataset:
Chemistry of the sulfur-nitrogen bond. VI. Convenient one-step synthesis of sulfenimines (S-aryl thiooximes) (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of the sulfur-nitrogen bond. VI. Convenient one-step synthesis of sulfenimines (S-aryl thiooximes)Franklin A. Davis, William A. R. Slegeir, Steven Evans, Alan Schwartz, David L. Goff, and Robert PalmerCite this: J. Org. Chem. 1973, 38, 16, 2809–2813Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://pubs.acs.org/doi/10.1021/jo00956a016https://doi.org/10.1021/jo00956a016research-articleACS PublicationsRequest reuse permissionsArticle Views593Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flavours and Fragrances (1997)

Chemoreception and structure activity relationships: toward a rational structure-function analysis of odour molecules - the olfactory receptor TM4 domain the impact of recombinant DNA-technology on the flavour and fragrance industry the design and synthesis of novel mugent materials aura of aroma - a novel technology to study the emission of fragrance from the skin dependence of intensity of musk odour on the energy gap between frontier and molecular orbitals. Essential oils and analytical: derivatized cyclodextrines in enantiomer GC separation of volatiles production, chemistry and sensory properties of natural isolates an odour sensing system for use in measuring volatiles in flavours and fragrances the aromatic resins studies towards structure determination of substituted pyrazines. Flavours: generation of taste through (Redox) biocatalysis the Maillard reaction in flavour formation relationships between sensory time-intensity measurements and in nose concentration of volatiles. Organic chemistry: synthesis and odour properties of chiral fragrance chemicals in search of nascent musks...or not! synthesis and application of thiocarbonyl compounds heteropolyacids and related compounds as catalysts for fine chemicals synthesis.
Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland (2006)

In the current study of 139 FNAB specimens of thyroid Hurthle cell nodules, 14 cytologic features were examined and 6 were found to be statistically significant in identifying HCN. The following four features, when found in combination, were found to be highly predictive of HCN: nonmacrofollicular architecture, absence of colloid, absence of inflammation, and presence of TBV.
Genetic determinants of osteoporosis (2005)

Research has recently begun to clarify the genes and genetic variants that predispose to osteoporosis and regulation of bone mass. Clinical applications of this research include the identification of genetic markers for assessment of fracture risk and the identification of novel molecular targets for the design of drugs that can be used to treat bone disease.
Premature Concrete Deterioration in Texas Department of Transportation Precast Elements (1999)

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Fraud in Realty Transactions (1964)

In real estate transactions, the law will protect the innocent, unwary, and sometimes stupid, buyer from fraud, misrepresentation and deceit. This article presents a summary of that law, categorized according to the specific matter misrepresented (i.e., misrepresentations of value, income, size or quantity, and condition or quality).
Effect of Initial Total Oxygen Concentration on the Rate of SiO<SUB>2</SUB> Inclusion Removal from Molten Cu (1994)

The effect of initial total oxygen concentration, [mass%O]T0, on the rate of inclusion removal from molten copper has been investigated.Under the mechanical stirring condition, it is found that the rate constant of inclusion removal, ko, is independent of the rotation speed of stirrer, whereas it is dependent on [mass%O]T0. From the results of microscopic observation of inclusion particles with SEM, size distribution of inclusion particles is obtained. The rate constant, ko, increases with increasing initial value of particle number density and mean radius of inclusion particle. The change in ko with the initial content of inclusion in the metal phase can be interpreted in terms of coagulation of inclusion particles.Under Ar gas injection stirring condition, ko increases with increasing gas flow rate, while it does not apparently depend on [mass%O] T0. In the case of Ar gas injection stirring condition, the effect of coagulation on the rate of inclusion removal is smaller than that under the mechanical stirring condition. It is considered that the inclusion particles are removed from the melt mainly through adhesion to the gas bubble-metal interface.
Programmable bio-nano-chip system for saliva diagnostics (2014)

This manuscript describes programmable Bio-Nano-Chip (p-BNC) approach that serves as miniaturized assay platform designed for the rapid detection and quantitation of multiple analytes in biological fluids along with the specific applications in salivary diagnostics intended for the point of need (PON). Included here are oral fluid-based tests for local periodontal disease, systemic cardiac disease and multiplexed tests for drugs of abuse.
Connecting metabolism to inflammation: the role of <i>LACC1</i> in inflammatory diseases (2020)

Abstract Genome wide association studies (GWAS) identified several single nucleotide polymorphisms (SNPs) in inflammatory diseases. However, it is difficult to determine the gene that GWAS identified SNPs affect and in which cell type(s). RNA-seq analysis of immune cells from 89 healthy humans, led to the identification of the gene laccase domain containing 1 (LACC1), as one of the most promising targets for investigating the role of human gene polymorphisms in inflammatory bowel disease (IBD). LACC1 is a critical immunometabolic mediator in macrophages that drives fatty-acid oxidation. Surprisingly, we found that polymorphisms near LACC1 that have been linked to IBD correlated with significantly lower LACC1 expression in naïve and activated CD4 and CD8 T cells. No difference in expression was observed in macrophages, where it’s highly expressed and has been shown to influence macrophage function. Thus, we hypothesized that these polymorphisms contribute to the genetic risk for IBD by reducing LACC1 expression and, subsequently, inducing T cell dysfunction. As LACC1 plays an important role in macrophage fatty acid metabolism, we tested if this held true in T cells. In our study, knockdown of LACC1 in human CD4 T cells increased mitochondrial mass and lipid droplet formation. This change in metabolism was associated with a significantly reduced production of several cytokines, including IL-2 and IFNg, following anti-CD3/CD28 stimulation. Further, levels of expression of the T cell activation marker CD25 were also attenuated. In summary, our studies provide insights into new mechanisms controlling T cell metabolism and suggest that LACC1 may provide a target for regulating T cell function to prevent inflammatory and autoimmune diseases.
Development of solvent-based polyacrylate pressure sensitive adhesives (2005)

The solvent-based polyacrylate pressure sensitive adhesives (PSAs) were synthesized using solution copolymerization. The effects of the type and composition of comonomer, the chain-transfer agent content, the feeding manner of initiator, the polymerization temperature, the glue viscosity and the baking temperature on the adhesion properties of PSAs were studied. The results indicate that adhesion properties of PSAs are comprehensively improved by acrylic acid, the adjustment of molecular weight and its distribution of copolymer is realized mainly by different feeding manners of initiator, the stability of solution polymerization is maintained by chain-transfer agent, and the proper viscosity of glue and the proper baking temperature are significant to improve comprehensively adhesion properties of PSAs.
Catheter placement within the atrial septum: Demonstration of the potential space between the septum primum and septum secundum (1972)

Radiological interest in the atrial septum has centred almost exclusively on demonstration of defects within it, either of the primum or secundum variety. Demonstration of the septum itself has been limited to definition of either the right or left surface in contact with contrast material in the right or left atrial chambers, respectively. In the case to be described, catheter placement occurred between the two leaves of the septum and the contrast material injection demonstrated the potential space between the two leaves.
Pharmacokinetics and Tissue Distribution of Minocycline following Intravenous Administration in Rabbits (2017)

Multidrug-resistant A. baumannii, S. maltophilia, and B. cepacia have been identified as priority organisms of infectious diseases and as important causes of refractory pneumonia. These three pathogens require urgent attention for development of new therapeutic options. However, few if any novel antibacterial antibiotics against these organisms are available. In order to understand the impact of minocycline dose on plasma and tissue distribution, we conducted a detailed pharmacokinetic study in rabbits. NZW rabbits received a single dose of minocycline as an IV infusion with serial plasma sampling over 24 hours. During the second stage, minocycline was administered Q12h for 6 days at 6, 12, 24, 48, or 96 mg/kg with serial plasma sampling and tissue recovery on day 7. Plasma and tissue concentrations were determined by LC/MS/MS. Minocycline pharmacokinetic parameters were estimated using standard non-compartmental methods. The data show that minocycline tissue exposures increased with increasing minocycline doses and minocycline plasma levels increased in a dose-proportional manner. Minocycline was highly distributed in tissues and body fluids including choroid, epithelial lining fluid, alveolar macrophages, vitreous and aqueous humor, and CSF. The data show that minocycline tissue exposures increased with increasing minocycline doses and minocycline plasma levels increased in a dose-proportional manner. Minocycline was highly distributed in tissues and body fluids including choroid, epithelial lining fluid, alveolar macrophages, vitreous and aqueous humor, and CSF. These data suggest that administration of minocycline in rabbits should produce levels of drug that would be active against target organisms in plasma, tissues, and other body fluids. T. G. Nolan, The Medicines Company: Employee, Salary. D. C. Griffith, The Medicines Company: Employee, Salary. M. N. Dudley, The Medicines Company: Employee, Salary. T. J. Walsh, Astellas, Actavis, Contrafect, Drais, iCo, Novartis, Methylgene, Pfizer, Sigma-Tau: Consultant, Consulting fee. Astellas, Actavis, Merck, Novartis, Phizer, Sctnexis, Tetraphase, The Medicines Company, Theravance: Grant Investigator, Research grant.
An MCMC approach to solving hybrid factored MDPs (2005)

Hybrid approximate linear programming (HALP) has recently emerged as a promising framework for solving large factored Markov decision processes (MDPs) with discrete and continuous state and ac-tion variables. Our work addresses its major com-putational bottleneck – constraint satisfaction in large structured domains of discrete and continuous variables. We analyze this problem and propose a novel Markov chain Monte Carlo (MCMC) method for finding the most violated constraint of a relaxed HALP. This method does not require the discretiza-tion of continuous variables, searches the space of constraints intelligently based on the structure of factored MDPs, and its space complexity is linear in the number of variables. We test the method on a set of large control problems and demonstrate im-provements over alternative approaches. 1
Research Spotlights (2018)

The first of the two papers appearing in this issue's Research Spotlights section is “A Gillespie Algorithm for Non-Markovian Stochastic Processes,” by Naoki Masuda and Luis E. C. Rocha. This paper is concerned with stochastic dynamical modeling of interacting sequences of discrete events. Various applications include modeling of earthquake occurrences, modeling of networks of spiking neurons, and modeling of epidemic formation on networks. In this paper, the authors propose the Laplace Gillespie algorithm, which is distinguishable from previous variants of the Gillespie algorithm as a computationally efficient approach applicable to realistic, non-Poissonian renewal processes while being accurate for an arbitrary number of ongoing renewal processes. The easy-to-digest five-step algorithm is presented first. This is followed by presentation of the necessary and sufficient conditions for a renewal process to be simulated by the Laplace Gillespie algorithm and a long list of examples of distributions of interevent times for which the algorithm can be used. The authors demonstrate their new approach by performing exact simulations of an epidemic process. The codes used in the numerical simulations section are made available in the supplementary materials to readers who want to test this algorithm on their own application. The work in the second paper, “The Ghosts of Departed Quantities in Switches and Transitions,” by Mike R. Jeffrey, represents an addition to the literature on piecewise-dynamical systems theory. The author offers a derivation of and motivation for a new uniform switching model that allows for the study of dynamics at discontinuities. The key feature of the model is the inclusion of a term that is hidden outside the so-called switching layer. This term represents the ghosts, or artifacts, due to the transition, and it requires careful attention. The author shows how analyzing the hidden dynamics inside this layer from what is encoded in this term is extremely important to understanding local and global behavior of solutions. In one example, for instance, the author shows that even determining whether a system will cross through a switch cannot be done without considering the effects of nonlinearity at the switch. The paper concludes by offering the reader suggestions for future research and by making an appeal for the development of numerical solution methods aimed at “capturing the ghosts of switching” through the proposed model.
Defects in T-cell–mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector–mediated gene transfer into repopulating hematopoietic cells (2003)

The Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by immune dysfunction, thrombocytopenia, and eczema. We used a murine model created by knockout of the WAS protein gene (WASP) to evaluate the potential of gene therapy for WAS. Lethally irradiated, male WASP- animals that received transplants of mixtures of wild type (WT) and WASP- bone marrow cells demonstrated enrichment of WT cells in the lymphoid and myeloid lineages with a progressive increase in the proportion of WT T-lymphoid and B-lymphoid cells. WASP- mice had a defective secondary T-cell response to influenza virus which was normalized in animals that received transplants of 35% or more WT cells. The WASP gene was inserted into WASP- bone marrow cells with a bicistronic oncoretroviral vector also encoding green fluorescent protein (GFP), followed by transplantation into irradiated male WASP- recipients. There was a selective advantage for gene-corrected cells in multiple lineages. Animals with higher proportions of GFP+ T cells showed normalization of their lymphocyte counts. Gene-corrected, blood T cells exhibited full and partial correction, respectively, of their defective proliferative and cytokine secretory responses to in vitro T-cell-receptor stimulation. The defective secondary T-cell response to influenza virus was also improved in gene-corrected animals.
Organic Matter Fractions from Organically and Conventionally Managed Soils: I. Carbon and Nitrogen Distribution (1996)

Abstract Chemical and physical fractionation techniques were used to study the effects of organic and conventional management practices on soil organic matter (SOM) characteristics. We isolated SOM from: (i) organic animal‐based, manure‐amended (ORG‐AN), (ii) organic cash‐grain‐based, cover cropped (ORG‐CC), and (iii) conventional, cash‐grain‐based (CONV) rotations. We quantified the total C and N contents of humin (HN) and humic substances (HS), and light (LF), heavy (HF), fine organo‐clay, and organo‐sand fractions. Management changed the quantity and distribution of C and N in physically and chemically isolated fractions. The ORG‐CC soil had significantly greater quantities of C in its HN, HS, LF, and HF fractions than the CONV soil. Management impacted the distribution of C and N only in the LF fraction. The ORG‐CC had a larger percentage and proportion of C and N in its LF than the other soils. The percentage of soil N in HS was higher in the ORG‐AN and ORG‐CC than in the CONV soil. Even though the quantity of N in the CONV's HN equaled the other soils, it had the highest percentage and proportion of N allocated to this fraction. Farming systems did not significantly alter the C and N contents of HS or the quantity of C associated with selected particle‐size fractions; however, the C content of fine clay isolated from aggregated soil was significantly greater than the C content of clay isolated from loose soil. By isolating macroorganic matter (LF) in concert with HS and HN fractions, we were able to assess management practice impacts on SOM characteristics.
NATURAL PHOSPHATE DOPED WITH KI IN HMDS: A MILD AND EFFICIENT REAGENT FOR ALKYLATION AND GLYCOSYLATION OF NUCLEOBASES (2005)

Several D-ribonucleosides are prepared from 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranoside and trimethylsilylated nucleobases under mild conditions by using natural phosphate doped with KI as catalyst.
The low and high frequency limits for anisotropic parameters in a layered medium (2007)

The aim of this work is to investigate the relationship between the layer-induced anisotropic parameters ε and δ from two layer isotropic medium when calculated in the low frequency limit (by Backus averaging) and in the high frequency limit (from the PP ans SS traveltime parameters). It shown that the effective medium from both PP and SS traveltime parameters computed from a two layer isotropic medium is not exactly a VTI medium. Nevertheless, the approximate solution can be used. The comparison between the low frequency limit and both PP and SS high frequency limits is discussed on synthetic and real data examples.
Clarification of sonic lysates of Mycobacterium tuberculosis. (1974)

A method is presented for clarifying sonic lysates of Mycobacterium tuberculosis. This is achieved by treating the lysate with ammonium sulfate to 70 per cent saturation, and then dialyzing the entire preparation. This treatment causes flocculation of lipid and other debris, and facilitates clarification and filter sterilization of the remaining solution of macromolecular constituents.
Organic heterocyclothiazenes. Part 2. Reaction of tetrasulphur tetranitride with phenylacetylene and diphenylacetylene (1987)

The reaction of S4N4 with diphenylacetylene in boiling toluene has been found to give 3,4-diphenyl-1,2,5-thiadiazole (1) as the major product and 3,5-diphenyl-1,4,2,6-dithiadiazine (4), a new heterocyclic system, as a minor product. The same reaction with phenyacetylene gives 3-phenyl-1,2,5-thiadiazole (12) and the novel 1,3,2-dithiazolylimine (16), the first example of this mesoionic ring. These new structures correct literature assignments. Reaction mechanisms are proposed for the formation of the products.
Survival Schools: The American Indian Movement and Community Education in the Twin Cities (2014)

Julie L. Davis, Survival Schools: The American Indian Movement and Community Education in the Twin Cities. Minneapolis: University of Minnesota Press, 2013. 328 pages. ISBN 978-0-8166-7429-9. $22.95 USD paperback.What might have motivated a group of Indian people in 1972 to create their own independent schools in the heart of the Twin Cities? American historian Julie Davis sought the answer to this question in her quest to understand the American Indian Movement (AIM) and its place in the history of Native American activism in education. In recounting the story of the Heart of the Earth school in Minneapolis and the Red School House in St. Paul, the author reminds us that AIM, then and now, is about more than political protest: the survival school initiative evolved directly out of AIM's local activism in matters of education, child welfare, and juvenile justice.For readers like myself who began reading the book with little knowledge of AIM Davis gives a clear synopsis of its history. Organized in Minneapolis in July 1968 by local Indian people fed up with racism, discrimination, and socioeconomic disparities, AIM started as a nexus of experiences that developed and converged over time. If diverse in origin, the collective always sought to secure and expand Native American civil rights, of which access to culturally-relevant education, of course, is one.In postwar Minneapolis and St. Paul, both stable employment and decent housing became increasingly scarce for Indian people. In response, AIM leaders developed an ideology stressing pride in Indian heritage. If the challenges of contemporary urban life stemmed from cultural loss, Native peoples' cultural persistence was essential to their survival. Early AIM leaders believed that public schools could not offer Indian children identity and pride in their cultural heritage. Envisioning a different kind of education that could, led some AIM people to establish the alternative Heart of the Earth and the Red School House.Davis is thorough and open about her bias as a researcher. She tells us she was not raised as a Native person and does not write as an Indigenous scholar. She did, however, grow up on the Leech Lake reservation and had many friends who were Ojibwe people. Davis aceveryone knowledges that the story she tells is her version of the schools' history, a version shaped by the environment in which she grew up.At times the stories seem repetitive, and yet Davis stays true to her goal to listen to Indigenous people talk about their experiences. Her version of the school's history and her attempts to interpret faithfully may have led to a desire to thread many similar stories together. The voices represented are consistent in their message. For young people labeled as troublemakers, who may not have experienced academic success in traditional educational environments, the survival school's unconventional structure was a radical and potentially empowering environment. …