gebhart/patrepeval huggingface dataset:
Overexpression of vascular endothelial growth factor164 and its co-receptor neuropilin-1 in estrogen-induced rat pituitary tumors and GH3 rat pituitary tumor cells. (2000)

We have shown previously that the VEGF system plays a crucial role in regulation of tumor angiogenesis during the development of estrogen-induced prolactin-secreting pituitary tumors in Fisher 344 rats. Studies also suggested that both endothelial and non-endothelial cells expressed VEGF. However, several questions concerning the VEGF signals in regulation of estrogen-induced angiogenesis in rat pituitary remained unanswered. VEGF exists in a number of isoforms in human and rodent tissue (i.e., VEGF206h/205r, VEGF189h/188r, VEGF165h/164r, VEGF145h/144r and VEGF121) that differ in their molecular masses and biological activities. The VEGF isoforms bind with two tyrosine-kinase receptors, KDR/flk-1 and flt-1. In addition, VEGF165 binds with a newly identified co-receptor, neuropilin-1, which is expressed in human endothelial cells and several types of non-endothelial cells including tumor cells. The present study was undertaken to elucidate which isoforms of VEGF are predominantly expressed in normal Fisher 344 rat pituitaries, estrogen-induced prolactin secreting rat pituitary tumors and in prolactin secreting rat pituitary tumor cell line (GH3 cell line). To identify the isoform, RT-PCR with primer pairs derived from exon 1 and exon 8 of the VEGF gene, cloning, sequencing and Western blot analysis were performed. The status of neuropilin-1 in the rat pituitaries (normal and transformed) and GH3 pituitary tumor cell line has also been investigated using RT-PCR and Western blot analysis. These studies demonstrate that normal rat pituitaries, estrogen-induced rat pituitary tumors and GH3 pituitary tumor cells expressed VEGF164 and co-receptor, neuropilin-1. The VEGF164 was the predominant form in all of these cells. The VEGF164 and neuropilin-1 mRNA and protein levels were significantly higher in the estrogen-induced pituitary tumors and GH3 tumor cell line, as compared to normal pituitary. The data suggest that both VEGF164 and neuropilin-1 may actively participate in modulation of tumor angiogenesis and the development of pituitary tumors in Fisher 344 rats.
Optical torque exerted on a homogeneous sphere levitated in the circularly polarized fundamental-mode laser beam (1985)

An expression for a circularly polarized Gaussian laser beam is obtained from the electromagnetic vector potential A, of which the scalar part becomes the complex-source-point spherical wave. Based on the theory of laser-beam scattering by a stationary homogeneous sphere, the analytical formulas are derived for the optical torque components exerted on the levitated sphere in the circularly polarized focused laser beam. The optical torque is numerically calculated, and interpretations of the results are presented. For a sphere with size parameters ρ = (2πα/λ) = 10π and complex refractive index N = 1.47 + i0.000001, levitated at the center of a 1-W Ar+ laser beam, the z component of angular velocity in air ωrot,z is found to be about 4.0 rad/sec.
El ABP, un enfoque estratégico para la formación en Educación Superior. Aportaciones de un análisis de la formación en Derecho. (2011)

<p><em>Se ha generado un amplio consenso según el cual el aprendizaje basado en problemas permite promover mayores capacidades individuales para “aprender cómo aprender”, algo que nuestros estudiantes van a precisar en su aprendizaje futuro a lo largo de su vida profesional. En el análisis de los datos del caso desarrollado hemos pretendido encontrar argumentos sobre este consenso. Hemos analizado el grado de interés y de motivación para implicarse activamente los estudiantes en el desarrollo de una materia de Derecho, en formato de “proyecto”, y hemos visto el tipo de aprendizaje con el que se orientaron en este desarrollo así como el tipo de autorregulación que desempeñaron a lo largo de su proceso de estudio. Finalmente, se ofrecen tres tipos de argumentos que deberían ser considerados para diseminar propuestas como la que comentamos.</em><br /><br /><strong> </strong></p><p> </p>
Distortion and uncertainty in chirped pulse THz (2002)

A mathematical model of the behaviour of chirped pulse THz spectrometers is used to describe the response of the instrument to long and short pulses of high or low intensity. It is found that the output can be ambiguous because similar outputs can arise from dissimilar inputs.
Ergonomics and Safety in Hand Tool Design (1999)

This book focuses exclusively on ergonomics in the design and use of hand tools. Hand tools have been an integral supplement to the human hand since the beginning of civilization. Recently, they have been pinpointed as a prominent cause of workplace disease. Cumulative Trauma Disorders such as Tendonitus, Carpal Tunnel Syndrome, and Raynaud's Syndr
The development of a side effect risk assessment tool (ASyMS©-SERAT) for use in patients with breast cancer undergoing adjuvant chemotherapy (2009)

Abstract Patients with breast cancer receiving chemotherapy are at risk of developing toxicities which can be severe or life threatening. The aim of this study was to develop and test a side effect risk modeling tool (ASyMS © -SERAT) for use in patients with breast cancer undergoing adjuvant chemotherapy. The study was conducted in two phases. Phase 1 entailed the development of the ASyMS © -SERAT tool using a secondary data set and in collaboration with an expert group of clinicians and an advisory group of patients. In phase 2, the predictive accuracy of the tool was measured using a prospective data set of 24 patients with breast cancer undergoing adjuvant chemotherapy. A high level of accuracy was reported for four of the six symptoms measured (>70%) supporting the future development and application of ASyMS © -SERAT in the prediction of chemotherapy-related toxicity. For patients, such information can be used to target information on side effects that they are likely to experience thereby facilitating the provision of tailored information based on their individual needs. For clinicians, knowing the likelihood of potential side effects can assist them in identifying patients who are at greater risk of developing certain toxicities, facilitating more targeted and cost-effective interventions.
Madrasah Nizhamiyah Pengaruhnya terhadap Perkembangan Pendidikan Islam dan Aktivitas Ortodok Sunni (2015)

Berbicara mengenai lembaga pendidikan Islam tidak bisa dilepaskan dari pandangan atau konsep Islam itu sendiri mengenai pendidikan. Pendidikan Islam merupakan wujud dari pengaruh berbagai kebudayaan atau peradaban yang pernah ada dalam sejarah. Namun demikian para ahli pendidikan Islam biasanya berpandangan bahwa pendidikan Islam memiliki karakter dan tujuannya sendiri yang khas, karena ia didasarkan kepada tujuan yang bersifat metafisis-transendental, yaitu untuk mencapai keridlaan Allah SWT, di dunia dan akhirat. Seiring dengan perkembangannya pendidikan mendapat prioritas pada masa tersebut, dari mulai tingkat pendidikan yang paling rendah sampai paling tinggi. Baik yang dikelola oleh perorangan maupun pemerintah, pada masa ini pendidikan lebih banyak seperti yang dilaksanakan di rumah-rumah, kuttab-kuttab, dimesjid serta madrasah.Madrasah Nizhamiah mengalami puncak kejayaannya yang dipelopori oleh seorang perdana mentri bernama Nizham al-Mulk dengan dukungan berbagai macam fasilitas. Tujuan didirikanya Madrasah Nizhamiah untuk memperkuat pemerintah Bani Saljuk dan untuk menyiarkan madzhab keagamaan pemerintah, karena sultan-sultan Turki adalah dari golongan ahli sunnah.untuk menyokong sultan dalam menyiarkan mazhab ahli sunah. Penulisan ini mengungkap pada aspek lembaga pendidikan Nizhamiyah dalam pembentukan kurikulum, materi, tokoh terkenal, serta pengaruhnya terhadap pendidikan pada Madrasah Nizhamiyah dengan menggunakan pendekatan sosiohistoris atau pendekatan sejarah.
Phased array calibrations using measured element patterns (2002)

A technique to compensate for differences in phased array element patterns is presented. Each measured element pattern is approximated by a virtual array whose excitation function is determined by the Woodward-Lawson synthesis technique. By extending the virtual array beyond the physical array dimensions, mutual coupling and edge diffraction effects can be separated. An example is given where calibration by coupling matrix inversion resulted in significantly reduced array pattern sidelobes.
Inverse Gas Chromatography (1989)

Inverse gas chromatography (IGC) is an extension of conventional gas chromatography (GC) in which a non-volatile material to be investigated is immobilized within a GC column. This stationary phase is then characterized by monitoring the passage of volatile probe molecules of known properties as they are carried through the column via an inert gas. The invention of IGC in 1967 (1) and the subsequent development of IGC theory and methodology, beginning in 1976 (2) and continuing today, are the consequence of the increasing interest in materials science. While IGC was initially used only in the study of synthetic polymers, today, as evidenced in this book, IGC is used to study synthetic and biological polymers, copolymers, polymer blends, glass and carbon fibers, coal, and solid foods.
An Extracorporeal Device to Treat Barbiturate Poisoning (1966)

Each year in the United States there are more than 2,000 deaths due to barbiturates, accounting for more than 7% of all suicides.<sup>1</sup>Furthermore, in spite of all the new, potentially lethal pharmaceuticals introduced, barbiturates have been responsible for an increasing proportion of attempted suicides. This trend has been most marked in the last five years. When one considers that an estimated 7% of barbiturate suicide attempts are fatal<sup>2</sup>the incidence of barbiturate poisonings is apparently quite high. Several methods have been developed to treat the patient who is prostrated from an overdose of sleeping pills. These range from supportive therapy,<sup>3</sup>water diuresis,<sup>4</sup>alkaline diuresis,<sup>5-7</sup>alkaline or protein peritoneal dialysis,<sup>8</sup>to hemodialysis.<sup>9-11</sup>Although these methods are all applicable, a method of treatment more accessible, more rapid, and more economic would be desirable. In the past, most investigations with resins have been concerned with
Selection for Precise Chromosomal Targeting of a Dominant Marker by Homologous Recombination (1989)

The antibiotic resistance gene neomycin phosphotransferase (neo) has been precisely targeted to a chromosomal region close to the cystic fibrosis (CF) locus on chromosome 7. The chromosomal target was the expressed SV40 array integrated at chromosome 7, band q31-q35 in a human-mouse hybrid cell line that contains chromosome 7 as the only human component. Stringent selection for neo expression by homologous recombination (3 of 11 correctly targeted) was achieved by fusing the SV40 large T antigen gene, in frame, to neo in a promoterless construct, such that G418 resistance depended on endogenous promoter function and read-through transcription. Chromosome-mediated gene transfer (CMGT) with G418 selection was then used generate mouse hybrids that carried the targeted locus intact, but retained only a fragment of human chromosome 7. This gene targeting strategy will access new regions of the human (or other mammalian) genome, create precise mutations efficiently by gene disruption, and potentially restore normal gene function by mutation correction.
Review of the Properties and Reactions of Some Inorganic Free Radicals (1962)

The chemical properties and reactions of free radicals are more particularly emphasized, even though the more spectacular recent advances in our understanding of free radicals have come through the use of tools and techniques taken from the domain of the physicist. It seems worthwhile to explore whether or not the methods of classical chemistry with suitable modifications can be developed further to increase our knowledge of transformations involving free radicals. The stabilization of various radicals and the type of reactions characteristic of divalent radicals are discussed.
A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis (2015)

Despite numerous investigations on metastasis, the determinants of metastatic processes remain unclear. We aimed to identify the metastasis-associated genes in hepatocellular carcinoma (HCC). Potent metastatic SK-hep-1 (SK) cells, designated 'SKM', were generated using Transwell assay followed by selection in a mouse model. Genes expressed differentially in SKM and SK cells were identified via microarray analyses. A small form of Neural precursor cell-expressed developmentally downregulated 4 (sNEDD4) was identified to be overexpressed in SKM cells, which was confirmed as a novel transcript using liquid chromatography-mass spectrometry. In clinical specimens, sNEDD4 was significantly overexpressed in tumors and serves as a poor prognostic factor for male patients with HCC (P = 0.035). Upon subcutaneous introduction of sNEDD4-overexpressing SK cells into flanks of nude mice, tumors grew faster than those of the control group. Furthermore, sNEDD4-mediated promotion of tumor metastasis was demonstrated in the orthotopic mouse model. Overexpression of sNEDD4 increased the invasive ability of SK cells through upregulation of matrix metalloproteinase 9 and inhibited serum deprivation-induced apoptosis via upregulation of myeloid cell leukemia 1. In conclusion, sNEDD4 is a novel metastasis-associated gene, which prevents apoptosis under nutrient restriction conditions. The present findings clearly support the prognostic potential of sNEDD4 for HCC.
The physical metallurgy of microalloyed steels (1998)

This volume provides a substantial background to microalloyed steels with a wide selection of applications, some of which are very recent. A well-illustrated practical guide, this book acts as a useful source of data and a concise account of the theoretical aspects of the subject. Both academic institutions and the world-wide steel industry will find it indispensable.
Political Allusions in the <i>Supplices</i> of Euripides (1890)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Peripheral Macrophages Promote Tissue Regeneration in Zebrafish by Fine-Tuning the Inflammatory Response (2019)

The role of macrophages during regeneration in zebrafish has been well-documented. Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous population of cells, and that they can play different roles during immune responses and in tissue restoration after damage and infection. In this work, we first aimed to classify zebrafish macrophages according to their distribution in the larva during homeostasis and after tissue damage, distinguishing peripheral, and hematopoietic tissue resident macrophages. We discovered differences between the migratory behavior of these two macrophage populations both before and after tissue damage, triggered by the amputation of the tail fin. Further, we found a specific role for peripheral tissue-resident macrophages, and we propose that these cells contribute to tail fin regeneration by down-regulating inflammatory mediators such as interleukin-1b (<i>il1b</i>) and by diminishing reactive oxygen species (ROS) in the damage site. Our work suggests that specific macrophage populations recruited after tissue damage in zebrafish larvae can display different functions during both inflammation and tissue regeneration.
United States Case Notes (1968)

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Contribution à la connaissance de la genèse de certaines bauxites de la R. S. de Roumanie (1966)

Après avoir décrit deux exemples de bauxite de Roumanie, l'auteur tente de préciser les conditions de genèse des bauxites.
Synthesis and polymerization of vinyl esters and vinyl ethers having bulky substituents (1973)

Abstract In order to clarify the effect of bulky substituents on the stereoregulation of vinyl monomers, vinyl‐1‐adamantanecarboxylate and vinyl 1‐adamantyl ether were synthesized and polymerized by radical and cationic mechanisms, respectively. As open‐chain models of the adamantyl group, vinyl trialkylacetate (alkyl = ethyl, n ‐propyl, and n ‐butyl) and vinyl tri‐ n ‐propylcarbinyl ether were also synthesized and polymerized. The adamantly group in the vinyl ester favored syndiotactic propagation in a manner similar to the trimethylcarbinyl group. Higher homologs of tri‐ n ‐alkylcarbinyl group showed higher syndiotacticity but this effect was saturated in higher members of the series. The effect of the adamantyl group in vinyl ether was similar to that of the tert ‐butyl group, leading to high isotacticity on cationic polymerizations in nonpolar solvents and to atactic polymers in polar solvents, but the tri‐ n ‐propylcarbinyl group was found unique in leading to what was assumed to be a heterotactic polymer. Polymers with the adamantyl group showed much higher softening points than polymers of the corresponding open‐chain groups.
Superionic Cathode Materials for All-Solid-State Li-S Batteries (2013)

Abstract not Available.
Digital audio lectures: a library's path to sustainability (2009)

Technology is rapidly transforming traditional library functions, and librarians must ensure that their libraries and services remain valuable, sensitive to user needs, and sustainable into the future.

Technological advances in the past several years have enabled libraries to create new services that before were not possible, such as virtual reference, personalized [online public access catalog (OPAC)] interfaces, or downloadable media that library customers can use in the comfort of their own homes. This increase in available technologies gives libraries the ability to offer improved, customer-driven service opportunities. [1]

The Robert Wood Johnson Medical School (RWJMS) Media Library used available technology to upgrade a thirty-year-old lecture recording service. The improved, customer-driven service not only assisted students with learning and helped faculty with curriculum development, it has more fully integrated the media library into the rest of the school and revitalized its basic mission.

As school librarians ponder using technology to enhance their services and to strengthen their role within larger the school framework, they may want to consider the experience at the RWJMS Media Library, which has produced sustainable results by responding to customer needs and preparing adequately for change.
The Green Capital Advantage (2008)

The figures and speech of passion are clinically polymorphous and heterogeneous: from the baroque of the mystical ecstasy, the iconophily of religious and political ideologies, the collector's usual fetishism and the paranoiac insanity of hatred to the passions of knowing and loving. These are at the same time a passion for life as well as for self-destruction, for showing oneself as well for not knowing oneself, for representing oneself as well as for non representing oneself. Passion bares the impossible of mourning, its real point that gives a boost to the continual work. Passion confronts us to the essence of the being, to its fundamental distress. The being, whose shadow is projecting itself on the object of the passion, gives a name and a face to that object, and receives back its marks. That explains why passion is always accompanied by suffering. Moreover, passion is suffering according to its etymology: until the XVIth century, the word "passionate" meant somebody who suffered physically. The nature of the object of the passion (a relic, a part of a sentence, an indication, the track of an object or any other subject) changes nothing to the structure of the speech of passion.
Prediction of Damage in Composite Cylinders After Impact (2005)

This paper presents the results from a study in two parts. The first part involves the identification and modeling of damage initiation and development in glass-reinforced epoxy composite cylinders subjected to drop weight impact. The second is concerned with the evaluation of the influence of this damage on the residual strength under hydrostatic pressure loading. Original results showing the influence of damage on implosion pressure are presented. The improved understanding of these phenomena and the development of predictive tools is part of an ongoing effort to improve the long-term integrity of composite structures for underwater applications.
Active Caspase-1-Mediated Secretion of Retinoic Acid Inducible Gene-I (2008)

Caspase-1 is an inflammatory caspase that controls the activation and secretion of the inflammatory cytokines, IL-1beta and IL-18. We observed that cellular levels of retinoic acid-inducible gene-I (RIG-I) were enhanced when the pan-caspase inhibitor Z-VAD-fmk or caspase-1-specific inhibitor Z-WEHD-fmk blocked caspase activity. Overexpression of caspase-1 reduced cellular levels of RIG-I and inhibited RIG-I-mediated signaling activity. Enzymatic activity of caspase-1 was necessary to control RIG-I, although it was not a substrate of proteolytic cleavage by caspase-1. Caspase-1 physically interacted with full length RIG-I, but not with mutant forms lacking either the amino- or carboxyl-terminal domains. RIG-I was present in the supernatant of cells transfected with active caspase-1 but not with caspase-4. Stimulating cells with LPS and ATP also induced secretion of endogenous RIG-I in macrophages. Our data suggest a novel mechanism that negatively regulates RIG-I-mediated signaling activity via caspase-1-dependent secretion of RIG-I protein.
Reducing the Cost of CO<sub>2</sub> Capture from Flue Gases Using Membrane Technology (2008)

Studies of CO2 capture using membrane technology from coal-fired power-plant flue gas typically assume compression of the feed to achieve a driving force across the membrane. The high CO2 capture cost of these systems reflects the need to compress the low-pressure feed gas (1 bar) and the low CO2 purity of the product stream. This article investigates how costs for CO2 capture using membranes can be reduced by operating under vacuum conditions. The flue gas is pressurized to 1.5 bar, whereas the permeate stream is at 0.08 bar. Under these operating conditions, the capture cost is U.S. $54/tonne CO2 avoided compared to U.S. $82/tonne CO2 avoided using membrane processes with a pressurized feed. This is a reduction of 35%. The article also investigates the effect on the capture cost of improvements in CO2 permeability and selectivity. The results show that the capture cost can be reduced to less than U.S. $25/tonne CO2 avoided when the CO2 permeability is 300 barrer, CO2/N2 selectivity is 250, and the membrane cost is U.S. $10/m2.