gebhart/patrepeval huggingface dataset:
Red Blood Cell Transfusion Dependence and Outcome after Allogeneic Peripheral Blood Stem Cell Transplantation in Patients with de Novo Myelodysplastic Syndrome (MDS) (2008)

The prognosis of patients with de novo myelodysplastic syndrome (MDS) who are red blood cell transfusion-dependent (TD) and receive supportive care is inferior to that of patients who do not require transfusions. Whether TD also affects outcome after allogeneic transplantation is unknown. Consequently, in 172 de novo MDS patients (median age, 51 years), we analyzed the impact of TD on outcome after high-dose conditioning and allogeneic peripheral blood stem cell transplantation (PBSCT). With a median follow-up of 37 months, the probability of 3-year overall survival (OS) did not differ significantly between patients who were TD and those who were not TD before PBSCT (P=.1); however, transfusion burden, as reflected by ferritin levels, was correlated with a greater probability of severe acute graft-versus-host disease (aGVHD; P=.03) and a higher comorbidity index (P=.01), and OS was inferior in those patients with a ferritin level>1000 microg/L before PBSCT (P=.03). In multivariate analysis, only marrow myeloblast count (P=.01) and comorbidity index (P=.001) had a significant impact on OS. Our data do not identify TD as an independent negative prognostic factor for outcome after allogeneic PBSCT' however, iron overload (presumably transfusion-related) may contribute to poor transplantation success by adding to the overall comorbidities. Whether clinical intervention in the form of iron chelation can improve the outcome of allogeneic PBSCT in TD patients with MDS remains to be determined.
Melatonin Ameliorates Neurologic Damage and Neurophysiologic Deficits in Experimental Models of Stroke (2003)

This review summarizes the numerous reports that have documented the neuroprotective actions of melatonin in experimental models of ischemia/reperfusion injury (stroke). In these investigations, which have used three species (rat, gerbil, and cat), melatonin was universally found to reduce brain damage that normally occurs as a consequence of the temporary interruption of blood flow followed by the reflow of oxygenated blood to the brain. The exogenous administration of melatonin in these experimental stroke models reduced infarct volume, lowered the frequency of apoptosis, increased the number of surviving neurons, reduced reactive gliosis, lowered the oxidation of neural lipids and oxidatively damaged DNA, induced bcl-2 gene expression (the activity of which improves cell survival), upregulated excision repair cross-complementing factor 6 (an essential gene for preferential DNA excision repair), restrained poly(ADP ribose) synthetase (which depletes cellular NAD resulting in the loss of ATP) activity, and improved neurophysiologic outcomes. Under no circumstances did melatonin exacerbate the damage associated with ischemia/reperfusion injury. As well as the beneficial pharmacologic actions of melatonin, several studies show that a relative deficiency of endogenous melatonin exaggerates neural damage due to stroke; this suggests that even physiologic concentrations of melatonin normally serve to protect the brain against damage. The primary action to explain melatonin's protective effects may relate to its ubiquitous direct and indirect antioxidative actions, although other beneficial functions of melatonin are not precluded.
Nanocomposites of Tantalum‐Based Pyrochlore and Indium Hydroxide Showing High and Stable Photocatalytic Activities for Overall Water Splitting and Carbon Dioxide Reduction (2014)

Nanocomposites of tantalum-based pyrochlore nanoparticles and indium hydroxide were prepared by a hydrothermal process for UV-driven photocatalytic reactions including overall water splitting, hydrogen production from photoreforming of methanol, and CO2 reduction with water to produce CO. The best catalyst was more than 20 times more active than sodium tantalate in overall water splitting and 3 times more active than Degussa P25 TiO2 in CO2 reduction. Moreover, the catalyst was very stable while generating stoichiometric products of H2 (or CO) and O2 throughout long-term photocatalytic reactions. After the removal of In(OH)3, the pyrochlore nanoparticles remained highly active for H2 production from pure water and aqueous methanol solution. Both experimental studies and density functional theory calculations suggest that the pyrochlore nanoparticles catalyzed the water reduction to produce H2, whereas In(OH)3 was the major active component for water oxidation to produce O2.
A SDRE-based asymptotic observer for nonlinear discrete-time systems (2005)

A nonlinear asymptotic observer for a discrete-time nonlinear system is considered. The observer is based on a Kalman filter that uses the state dependent Riccati equation (SDRE) to obtain the filter gain. Unlike the extended Kalman filter, the SDRE-based Kalman filter does not involve the evaluation of a Jacobian at every time step. The convergence properties of the SDRE-based Kalman filter when used as an observer in a deterministic setting are analyzed. A few simulation examples are provided to demonstrate the performance and implementation of the SDRE-based observer in both deterministic and stochastic settings.
Chemical research projects office: An overview and bibliography, 1975-1980 (1980)

The activities of the Chemical Research Projects Office at Ames Research Center, Moffett Field, California are reported. The office conducts basic and applied research in the fields of polymer chemistry, computational chemistry, polymer physics, and physical and organic chemistry. It works to identify the chemical research and technology required for solutions to problems of national urgency, synchronous with the aeronautic and space effort. It conducts interdisciplinary research on chemical problems, mainly in areas of macromolecular science and fire research. The office also acts as liaison with the engineering community and assures that relevant technology is made available to other NASA centers, agencies, and industry. Recent accomplishments are listed in this report. Activities of the three research groups, Polymer Research, Aircraft Operating and Safety, and Engineering Testing, are summarized. A complete bibliography which lists all Chemical Research Projects Office publications, contracts, grants, patents, and presentations from 1975 to 1980 is included.
Dissecting MMP P10′ and P11′ subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library (2018)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that remodel the extracellular matrix environment and mitigate outside-in signaling. Loss of regulation of MMP activity plays a role in numerous pathological states. In particular, aberrant collagenolysis affects tumor invasion and metastasis, osteoarthritis, and cardiovascular and neurodegenerative diseases. To evaluate the collagen sequence preferences of MMPs, a positional scanning synthetic combinatorial library was synthesized herein and was used to investigate the P<sub>10</sub>' and P<sub>11</sub>' substrate subsites. The scaffold for the library was a triple-helical peptide mimic of the MMP cleavage site in types I-III collagen. A FRET-based enzyme activity assay was used to evaluate the sequence preferences of eight MMPs. Deconvolution of the library data revealed distinct motifs for several MMPs and discrimination among closely related MMPs. On the basis of the screening results, several individual peptides were designed and evaluated. A triple-helical substrate incorporating Asp-Lys in the P<sub>10</sub>'-P<sub>11</sub>' subsites offered selectivity between MMP-14 and MMP-15, whereas Asp-Lys or Trp-Lys in these subsites discriminated between MMP-2 and MMP-9. Future screening of additional subsite positions will enable the design of selective triple-helical MMP probes that could be used for monitoring <i>in vivo</i> enzyme activity and enzyme-facilitated drug delivery. Furthermore, selective substrates could serve as the basis for the design of specific triple-helical peptide inhibitors targeting only those MMPs that play a detrimental role in a disease of interest.
Electro-Reduction of Molecular Oxygen Mediated by a Cobalt(II)octaethylporphyrin System onto Oxidized Glassy Carbon/Oxidized Graphene Substrate (2018)

The oxygen reduction reaction (ORR) is the most important reaction in life processes and in energy transformation. The following work presents the design of a new electrode which is composed by deposited cobalt octaethylporphyrin onto glassy carbon and graphene, where both carbonaceous materials have been electrochemically oxidized prior to the porphyrin deposition. The novel generated system is stable and has an electrocatalytic effect towards the oxygen reduction reaction, as a result of the significant overpotential shift in comparison to the unmodified electrode and to the electrodes used as target. Kinetic studies corroborate that the system is capable of reducing molecular oxygen via four electrons, with a Tafel slope value of 60 mV per decade. The systems were morphologically characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM) Electrochemical impedance spectroscopy studies showed that the electrode previously oxidized and modified with cobalt porphyrin is the system that possesses lower resistance to charge transfer and higher capacitance.
[Hypereosinophilic syndrome with DIC treated successfully with a combination of high-dose methylprednisolone and cyclosporin A]. (2001)

A 47-year-old man was admitted to our hospital with subcutaneous nodules on the bilateral lower legs and disseminated intravascular coagulation (DIC). Peripheral blood examination revealed leukocytosis with an increase of mature eosinophils, thrombocytopenia and abnormal coagulation. Bone marrow aspiration revealed an increased eosinophil count, and a diagnosis of hypereosinophilic syndrome (HES) was made. Prednisolone (PSL) therapy was not effective. Subsequent methylPSL pulse therapy followed by PSL brought about a transient improvement of the HES and DIC, but after reduction of the PSL, the HES worsened. After addition of cyclosporin A to the PSL, however, the HES improved and did not worsen.
Majority-based logic synthesis for nanometric technologies (2014)

Majority-based logic has received considerable attention due to emergent technologies that use the majority function as basic operation. As a consequence, the design of digital circuits using the majority-based logic has also been considered. Existing works essentially proposed different cell libraries to be applied in logic synthesis. However, the comparison between different approaches may not be straightforward since distinct circuit synthesis methodologies may be exploited. In order to allow a fair comparison of methodologies of generating quantum cellular automata (QCA) cell libraries and for performing QCA circuit synthesis is presented. The proposed library generation methodology is generic enough so that different basic logic functions can be considered. In addition to previous considered libraries, this work also considers a library comprising all 3-input functions implemented using both majority and AND-OR-Inverter gates. Experimental results compare different QCA libraries, showing that considering different basic gates leads to an average area reduction of up to 47%.
Bromination of 1-Hydroxyimidazoles. Synthesis and Crystal Structures (2012)

Bromination of 1-hydroxyimidazole 3-oxide and 1-hydroxy-2-methylimidazole 3-oxide using bromine in acetic acid gave 2-bromo-1,3-dihydroxyimidazole hydrobromide and 4,5-dibromo-1,3-dihydroxy- 2-methylimidazole hydrobromide, respectively. In contrast, bromination in aqueous mixture (acetic acid, methanol, dimethylformamide, tetrahydrofuran) yielded 2,4,5-tribromo-1-hydroxyimidazole. Crystal structures of four compounds were determined by X-ray diffraction.
Bioactivity of permselective <scp>PVA</scp> hydrogels with mixed <scp>ECM</scp> analogues (2015)

The presentation of multiple biological cues, which simulate the natural in vivo cell environment within artificial implants, has recently been identified as crucial for achieving complex cellular functions. The incorporation of two or more biological cues within a largely synthetic network can provide a simplified model of multifunctional ECM presentation to encapsulated cells. Therefore, the aim of this study was to examine the effects of simultaneously and covalently incorporating two dissimilar biological molecules, heparin and gelatin, within a PVA hydrogel. PVA was functionalized with 7 and 20 methacrylate functional groups per chain (FG/c) to tailor the permselectivity of UV photopolymerized hydrogels. Both heparin and gelatin were covalently incorporated into PVA at an equal ratio resulting in a final PVA:heparin:gelatin composition of 19:0.5:0.5. The combination of both heparin and gelatin within a PVA network has proven to be stable over time without compromising the PVA base characteristics including its permselectivity to different proteins. Most importantly, this combination of ECM analogues supplemented PVA with the dual functionalities of promoting cellular adhesion and sequestering growth factors essential for cellular proliferation. Multi-functional PVA hydrogels with synthetically controlled network characteristics and permselectivity show potential in various biomedical applications including artificial cell implants.
Electrical Power System Assessment Method Based on Bayesian Networks (2013)

<div class="section abstract"><div class="htmlview paragraph">The impact of the design of automotive electrical distribution systems (EDS) is becoming more and more significant with the continuous integration of new safety-relevant functions and the substitution of mechanical systems having reached a high degree of robustness. The introduction of hybrid and electric vehicles amplify this trend and lead to the design of even more complex electrical networks with multiple voltage levels and new challenges.</div><div class="htmlview paragraph">To assess electrical power systems with respect to their ability to supply the involved electrical consumers in various driving and consuming situations at a high level of reliability and voltage stability simulation studies, bench testing and driving tests are conducted. However, a sustained strategy to define relevant consuming and driving situations in order to test the EDS under consistent loading conditions is missing. The total installed electrical power being much larger than the available generator power, a dedicated strategy to define which electrical loads are likely to be switched simultaneously is needed. As this is dependent upon driving situations and environment conditions and possesses a probabilistic character, an adapted Bayesian network-based strategy is proposed in this paper to generate consistent loading situations in order to assess the design of the power network.</div><div class="htmlview paragraph">In this paper the stimuli generation based on a Bayesian network is introduced and discussed. The test sequences generated have been implemented on a test bench for electrical power systems to prove their efficiency. The analysis conducted on the generated stimuli and the results produced on the test bench are presented and discussed.</div></div>
Serologic Evidence of West Nile Virus Infection in Black Bears (Ursus americanus) from New Jersey (2003)

Serum samples obtained from 51 free-ranging black bears (Ursus americanus) in northwestern New Jersey in February and March 2002 were analyzed for neutralizing antibodies to West Nile virus (WNV) and St. Louis encephalitis virus. Three (6%) of the black bears tested positive for WNV-neutralizing antibodies. One additional sample was positive for flavivirus-neutralizing antibodies but could not be differentiated for a specific virus type. This is the first report of WNV infection in black bears.
Quantitative structural characterization of GaN quantum dot ripening using reflection high-energy electron diffraction (2007)

Reflection high-energy electron diffraction (RHEED) was used to monitor the strain of GaN/AlN quantum dots (QDs) grown by molecular beam epitaxy. Quantitative and absolute values of the in- and out-of-plane strains of the QDs were determined and compared to reference values, obtained by x-ray diffraction measurements. A very good agreement was found between RHEED and x-ray measurements. The growth and thermal ripening of the dots were analyzed. A progressive strain relaxation was observed during the ripening stage, suggesting a morphology evolution of the dots.
Predicting Multiprocessor Memory Access Patterns with Learning Models (1997)

A neural network based technique is introduced which hides the control latency of reconfigurable interconnection networks (INS) in shared memory multiprocessors. Such INS require complex control mechanisms to reconfigure the IN on demand, in order to satisfy processor-memory accesses. Hiding the control latency seen by each access improves multiprocessor performance significantly. The new technique hides control latency by employing a time-delay neural network (TDNN) as a prediction technique that learns the current processor-memory access patterns and predicts the need to reconfigure the IN. Training and prediction of the TDNN is performed on-line. Based on three experiments, the TDNN is able to learn repetitive patterns and predict the need to reconfigure the IN thus, effectively hiding control latency of processor-memory accesses. 1
Formal Probabilistic Timing Verification in RTL (2013)

Variations in timing can occur due to multiple sources on a chip such as process variations and variations in input patterns. It is desirable to have variation awareness at the register transfer level (RTL), and estimate block level delay distributions early in the design cycle, to evaluate design choices quickly and minimize postsynthesis simulation costs. In previous work, we introduced statistical high-level analysis and rigorous performance estimation (SHARPE), a rigorous, systematic methodology to verify design correctness in RTL in the presence of variations. We described SHARPE in the context of computing statistical delay invariants with respect to input variations. We treated the RTL source code as a program and used static program analysis techniques to compute probabilities. We modeled the probabilistic RTL modules as discrete time Markov chains that are then checked formally for probabilistic invariants using PRISM, a probabilistic model checker. In this paper, we extend SHARPE to perform timing verification in RTL in the context of process variations. We achieved this by obtaining a set of process variation-aware RTL delay models and correspondingly modifying the existing steps in SHARPE. We illustrate SHARPE on the RTL description of the datapath of OR1200, an open source embedded processor. We also apply SHARPE to other data-intensive RTL designs such as nontrivial components of communication systems and a few benchmark designs.
Bone Mineral Assessment With Dual Energy Computerized Tomography (CT) Imaging (1985)

Single kVp and dual energy CT imaging were utilized for the assessment of bone mineral content. In this approach, the CT values obtained from the trabecular portion of the lumbar vertebrae were related to known mineral concentrations in compartments of a calibration phantom that is scanned simultaneously with the patients. Both pre-reconstruction and post reconstruction dual energy CT methods were utilized in this study. The results obtained from single kVp scans were compared with the data from dual kVp scans. The influence of marrow fat content, variations in the calibration phantom, beam hardening effects and scanner drifts upon the accuracy and precision of the bone mineral measurements were investigated.
Diagnosis, Contact Lens Prescribing, and Care of the Keratoconus Patient (1999)

Introduction Incidence and Prevalence Etiology Symptomatology Early Signs Slit Lamp Biomicroscopic Signs Keratoscopic Findings Classification Schemes Impact on Patients Progression Spectacle Correction Rigid Contact Lens Correction Hydrogel Contact Lens Correction Piggyback and Hybrid Contact Lens Systems Gas Permeable Scleral Lenses Contact Lens Troubleshooting Indications for Surgery Summary
BIRTH OF A SIBERIAN TIGER CUB {PANTHERA TIGRIS ALTAICA) FOLLOWING LAPAROSCOPIC INTRAUTERINE ARTIFICIAL INSEMINATION (1993)

A 7-yr-old female Siberian tiger (Panthera tigris altaica) was treated with equine cho rionic gonadotropin followed 80 hr later by human chorionic gonadotropin (hCG) to stimulate follicular development and ovulation, respectively. Laparoscopy 46 hr after hCG revealed that the ovaries contained eight fresh corpora lutea and six preovulatory follicles. A 16-gauge catheter was inserted transabdominally into each uterine horn, and 16.8 x 106 motile spermatozoa (from a male designated by the Siberian Tiger Species Survival Plan (SSP)) were inseminated. Pregnancy was confirmed 45 days after insemination by ultrasound, and a single healthy male cub was born at 111 days of gestation. These results demonstrate for the first time that assisted reproductive technology can be used to produce genetically valuable offspring from parents identified and recommended by an SSP program.
SOME PROPERTIES OF A MICROSOMAL FRACTION PREPARED FROM TOMATO FRUIT (1982)

A method is described for preparation of a microsomal fraction from tomato fruits at various stages of ripeness. Electron microscopic examination of the membrane fractions was performed. The membrane preparation utilized molecular oxygen in the presence of NADH. This utilization was increased when cytochrome c was added, and cytochrome c enhanced the disappearance of NADH. Cytochrome c reduction was approximately equal to the loss of NADH. Cytochrome c reductase activity was not affected by stage of ripeness. Cytochrome c enhanced both O2 uptake and NADH utilization by the tomato microsomes. Monophasic Arrhenius plots were observed for oxygen utilization by the microsomal fractions in the presence or absence of cytochrome c.
Bond Energy Data Summarized (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBond Energy Data SummarizedNicholas K. Kildahl Cite this: J. Chem. Educ. 1995, 72, 5, 423Publication Date (Print):May 1, 1995Publication History Received3 August 2009Published online1 May 1995Published inissue 1 May 1995https://doi.org/10.1021/ed072p423RIGHTS & PERMISSIONSArticle Views1480Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
ChemInform Abstract: Comparison of Two Methods for Predicting Aqueous Solubility. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.