gebhart/patrepeval huggingface dataset:
EFFECT OF REDUCED MUSCLE TEMPERATURE ON ECCENTRIC EXERCISE-INDUCED MUSCLE DAMAGE 1120 (1996)

Eccentric muscle actions produce a greater increase in muscle temperature compared with concentric actions. It has been suggested that higher muscle temperature generated during eccentric actions is a factor of eccentric exercise-induced muscle damage. If so, then reducing muscle temperature during eccentric exercise should reduce muscle damage. Therefore the purpose of this study was to investigate the effect of icing prior to eccentric exercise on eccentric exercise-induced muscle damage. Eight female students(18.6±0.7 yrs) who were not participating in any resistance training program performed about of 12 maximal eccentric actions of the elbow flexors with each arm. One arm performed the exercise after being applied ice (0°C) for 10 min over the elbow flexors (treatment), and the other arm preformed the same exercise without any treatment (control). The two conditions were separated by 2-4 weeks and presented in balanced order. The icing reduced muscle temperature (assessed by a deep body temperature monitor) about 10 °C. Muscle temperature was still 5-8 °C lower when the eccentric exercise started, and muscle temperature of the treatment arm was 2-3 °C lower right after the exercise comparing to the control arm. Isometric force (IF), range of motion, muscle soreness, circumference of the elbow flexors, plasma creatine kinase activity (CK), and B-mode ultrasound pictures of the elbow flexors were measured before and for 5 days after exercise. All measures changed significantly (p<0.05) after exercise, however the changes were not significantly different between the treatment and the control. For example, IF decreased from 104.8±5.4 to 56.5±4.2 N at 1 day after exercise for the treatment and 103.5±4.4 N to 58.3±5.3 N, respectively, for the control. Peak CK for the treatment and control was 2,982±1,400 IU/L and 3,308±1,417 IU/L, respectively. From these results, it is unlikely that higher muscle temperature generated during eccentric exercise is a primary cause of larger development of muscle damage in eccentric exercise. It is also important to note that reduced muscle temperature does not appear to increase muscle damage susceptibility by increasing the stiffness of muscle or connective tissue.
Manif d'art 2 (2003)

This publication features work by each artist or collective that took part in the second Manifestation internationale, the theme of which was happiness and its imitations. Detailed documentation is also provided on peripheral exhibitions and satellite activities including dance performances, radio spots, music, video and film screenings, a crafts exhibition and a symposium. Comes with a site map and a program of activities. Texts in English and French.
B‐cell lymphomas involving the skin associated with hepatitis C virus infection (2002)

These results show that a subset of B-cell cutaneous NHL is associated with a replicative HCV infection and suggest that HCV is not involved in lymphomagenesis through a direct infection of malignant cells. The ability of HCV to trigger a chronic B-cell lymphoproliferation could represent another mechanism, while a fortuitous association cannot be excluded.
Spatial characterization of nanotextured surfaces by visual color imaging (2016)

We present a method using an ordinary color camera to characterize nanostructures from the visual color of the structures. The method provides a macroscale overview image from which micrometer-sized regions can be analyzed independently, hereby revealing long-range spatial variations of the structures. The method is tested on injection-molded polymer line gratings, and the height and filling factor are determined with confidence intervals similar to more advanced imaging scatterometry setups.
Larreantin, a novel, cytotoxic naphthoquinone from Larrea tridentata (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLarreantin, a novel, cytotoxic naphthoquinone from Larrea tridentataZeyuan Luo, Duangdeun Meksuriyen, Clemens A. J. Erdelmeier, Harry H. S. Fong, and Geoffrey A. CordellCite this: J. Org. Chem. 1988, 53, 10, 2183–2185Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/jo00245a011https://doi.org/10.1021/jo00245a011research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Surfactant protein (SP) B associations and interactions with SP‐A in white and black subjects with respiratory distress syndrome (2001)

The SP-B polymorphisms are important determinants for RDS. These may identify differences between black and white subjects, as well as, between males and females regarding the risk for RDS. Furthermore, SP-A susceptibility or protective alleles, in specific SP-B background, are associated, based on OR, with an increased or reduced risk for RDS.
Efficient Microwave Combinatorial Parallel and Nonparallel Synthesis of N-Alkylated Glycine Methyl Esters as Peptide Building Blocks (2005)

An easy and convenient microwave-assisted synthesis of N-alkylated glycine methyl esters is described. Parallel and nonparallel combinatorial methods are described and compared. The described reactions are reductive alkylations of several aldehydes and glycine methyl ester in the presence of NaBH3CN. Good yields and short reaction times are the main aspects of these procedures.
A Categorical Perception Model in Consideration for Illuminant Changes Using Neural Network (2005)

We developed a model that can operate similarly to human categorical color perception. The color of an object is not exclusively determined by the reflection spectrum from the surface of the object but is greatly affected by the ambient environmental conditions and depends upon color constancy, The mechanism of color constancy, however, is not explained in detail so acquiring the cognition of the categorical color name of objects under different illuminations is difficult. To that end, the relationship between the chromaticity and the categorical color perception of colored chips under different illuminations is the product of a categorical color-naming experiment was learned by using a neural network. The results showed that the obtained neural network has similar characteristics to those of human vision system.
A Normalised Performance Measure for Quadratic Time-frequency Distributions (2002)

The use of T-cell receptor (TCR) genes as markers for antigen-reactive T cells is dependent on the ability of the TCR genes to rapidly identify antigen-reactive T-cell clonotypes in patient samples. We recently reported a competitive reverse-transcriptase polymerase chain reaction (cRT-PCR) method that can measure the frequency of individual TCRBV subfamilies and clonotypes in mixed lymphocyte populations more accurately than other semiquantitative PCR assays. However, it is impractical to measure changes in the absolute frequency of each TCRBV subfamily to identify those T cells with increasing frequency after antigen stimulation in vivo or in vitro. Therefore, we have modified our cRT-PCR method to more rapidly identify expanding T-cell populations by combining all of the TCRBV subfamily-specific competitors into a single sample to determine the relative abundance of each TCRBV subfamily. Using an expanding TIL 620 culture, we identified four TCRBV (BV2, BV12, BV17, and BV23) subfamilies that expanded over a 23-day period. These subfamilies accounted for 23% of the T cells in the day 35 culture and increased to 57%, 92%, and 80% of the days 44, 51, and 58 cultures respectively. Analysis of DNA sequences demonstrated that the observed expansion was caused primarily by a single clonotype within each subfamily. T cells expressing BV17 and BV23 recognized gp100 and MART-1 respectively. Therefore, this cRT-PCR method can detect expanding T-cell populations based solely on their TCRBV subfamily expression. Furthermore, T-cell expansion in a mixed TIL population was a good predictor of antigen reactivity.
Respective importance of scatter, attenuation, collimator response and partial volume effect corrections for accurate quantification in /sup 123/I dopamine receptor imaging (2002)

The authors studied the relative importance of scatter correction (SC), attenuation correction (AC), depth-dependent collimator response (CC) and partial volume effect corrections (PVE) for accurate quantitative /sup 123/I brain SPECT. /sup 123/I activity was simulated in the putamen, caudate nuclei and background of the numerical Zubal brain phantom. Monte Carlo simulations including scatter, attenuation and collimator response effects were performed. The impact of all corrections was studied by reconstructing the projections using 29 schemes involving 2 reconstruction methods (FBP and OSEM), 3 SC (ideal, 20%, Jaszczak), 3 AC (ideal, iterative Chang, OSEM), 1 CC (frequency-distance principle) and 1 PVE correction (anatomically guided pixel-by-pixel algorithm). For each processing scheme, spatial resolution, binding potential (BP) and errors in striatal and background activity estimates were calculated. Results demonstrate: (1) the crucial role of CC for improved spatial resolution hence improved binding potential estimates; (2) the inaccurate striatal activity quantitation using SC+CC+AC only (errors /spl ges/50%); (3) the essential and effective role of PVE correction for accurate striatal activity quantitation (errors <13%). In conclusion, SC, AC and CC all help improve relative and absolute quantitation, but PVE correction is essential for absolute quantitation of striatal activity. PVE correction is effective provided high resolution anatomical information is available.
IR-MALDI-Mass Analysis of Electroblotted Proteins Directly from the Membrane:  Comparison of Different Membranes, Application to On-Membrane Digestion, and Protein Identification by Database Searching (1999)

A systematic membrane study investigating different neutral, cationic derivatized, and hydrophilic PVDF membranes for their suitability to carry out on-membrane tryptic digestions and to obtain infrared-matrix-assisted laser desorption/ionization (IR-MALDI) mass information on the proteolytic fragments directly from the membrane was performed. Clearly, the Immobilon CD membrane (Millipore) showed the most reproducible results over a protein mass range from 12 to 66 kDa. Typical protein load to SDS-PAGE was in the 1-2 micrograms range. The protein amount used for enzymatic treatment was estimated to be in the low picomole range. Now both the intact protein mass and the masses of the specific proteolytic fragments are available directly from the membrane. Protein databases can be searched via search algorithms on the Internet using the information on the intact protein mass and the masses, e.g., of its tryptic fragments. Investigations were performed to search for neutral, enzyme-compatible IR matrixes which allow the enzymatic treatment (on-membrane digestion) while the membrane is matrix-incubated. Thiourea could be tolerated during enzymatic cleavage in solution in concentrations of 15 g/L and resulted in high-quality spectra of intact protein signals and turned, therefore, out to be the most promising candidate.
In Vitro Aggregation Behavior of a Non-Amyloidogenic λ Light Chain Dimer Deriving from U266 Multiple Myeloma Cells (2012)

Excessive production of monoclonal light chains due to multiple myeloma can induce aggregation-related disorders, such as light chain amyloidosis (AL) and light chain deposition diseases (LCDD). In this work, we produce a non-amyloidogenic IgE λ light chain dimer from human mammalian cells U266, which originated from a patient suffering from multiple myeloma, and we investigate the effect of several physicochemical parameters on the in vitro stability of this protein. The dimer is stable in physiological conditions and aggregation is observed only when strong denaturating conditions are applied (acidic pH with salt at large concentration or heating at melting temperature T(m) at pH 7.4). The produced aggregates are spherical, amorphous oligomers. Despite the larger β-sheet content of such oligomers with respect to the native state, they do not bind Congo Red or ThT. The impossibility to obtain fibrils from the light chain dimer suggests that the occurrence of amyloidosis in patients requires the presence of the light chain fragment in the monomer form, while dimer can form only amorphous oligomers or amorphous deposits. No aggregation is observed after denaturant addition at pH 7.4 or at pH 2.0 with low salt concentration, indicating that not a generic unfolding but specific conformational changes are necessary to trigger aggregation. A specific anion effect in increasing the aggregation rate at pH 2.0 is observed according to the following order: SO(4)(-)≫Cl(-)>H(2)PO(4)(-), confirming the peculiar role of sulfate in promoting protein aggregation. It is found that, at least for the investigated case, the mechanism of the sulfate effect is related to protein secondary structure changes induced by anion binding.
Multi-modal virtual reality system for accessible in-home post-stroke arm rehabilitation (2013)

This paper presents a health economic system for motor recovery in patients with the commonest cause of death in some countries, stroke. The system is based on immersive, real-time motion capture (MOCA) available for private use and at the bedside. An interactive virtual reality (VR) interface designed with auditory and visual feedback. It consists on two scenarios and a 3D character that follows the user's arm movements by using the first and third person view metaphors of interaction. Two easy and enjoyable games are proposed for each scenario. The system is designed to be adapted to several tasks with different index of difficulty (ID) for gradual motor recovery in patients with stroke. The experiments carried out on eight healthy neurologically interact volunteers have shown that our system is suitable to be used at home on training programs, giving good references for future applications on stroke arm recovery.
Aflatoxin Formation in Preharvest Maize Ears Coinoculated with Aspergillus flavus and Aspergillus niger (1987)

ABSTRACTAspergillus flavus and Aspergillus niger commonly co-occur in preharvest maize and one report suggests that this association promotes a greater incidence of aflatoxin. Other studies have shown that Aspergillus niger can prevent, or substantially reduce, aflatoxin formation by Aspergillus flavus in autoclaved maize kernels, and this led us to examine the effect of A. niger on aflatoxin formation by A. flavus in preharvest maize where the bulk of aflatoxin accumulation occurs. Samples of kernels simultaneously wound-inoculated with equivalent numbers of A. flavus and A. niger conidia showed substantial aflatoxin contamination (mean = 9900 ppb) even though significantly more (P =.04) aflatoxin was produced in kernels wound-inoculated only with A. flavus (mean = 36,700). These same wounded kernels had a mean sample pH of 5.45 ± 0.44, well above substrate acidity levels (<pH 3.4) reported to prevent aflatoxin formation in autoclaved maize meal.Key Words: Aspergillus flavusAspergillus nigeraflatoxin formationmaize
Sesquiterpene Esters of Aristolochic Acid from the Root and Stem of <i>Aristolochia</i> <i>heterophylla</i> (1999)

Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells.
Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions (2010)

A greater understanding of the development of the malaria parasite within the mosquito is required to fully evaluate the impact of TBIs. If parasite-induced vector mortality influenced the population dynamics of Plasmodium species infecting humans in malaria endemic regions, it would be important to quantify the variability and duration of TBI efficacy to ensure that community benefits of control measures are not overestimated.
On‐site Screening for Urinary Hg Concentrations and Correlation with Glomerular and Renal Tubular Function (1991)

At the American Dental Association 1985 and 1986 Annual Sessions, an on-site screening for mercury was conducted as part of the Health Screening Program (HSP) to identify dentists having elevated urinary mercury concentrations. The data generated from this study were used to examine the relationship between elevated urinary mercury exposure and kidney dysfunction. Kidney dysfunction was assessed by measurement of serum and urine beta 2 microglobulin concentrations, serum creatinine, and creatinine clearance. The mean values found for urinary mercury were 5.8 micrograms Hg/L and 7.6 micrograms Hg/L for 1985 and 1986, respectively. Urinary mercury concentrations for this population were found to fall within the range of not detected to 115 micrograms Hg/L. Of the total number of participants assayed in 1985 and 1986, roughly 10 percent of the sample exhibited elevated mercury concentrations above 20 micrograms Hg/L. An analysis of the clinical markers indicated no clear relationship between elevated urinary mercury concentrations and kidney dysfunction. In addition to mercury testing, all dentists who participated in the 1985 and 1986 HSP were issued a questionnaire soliciting information as to their professional exposure. Those participants who were identified as having elevated urinary mercury concentrations in the 1985 HSP were issued a followup questionnaire that addressed psychological and neuropsychological symptoms. From these questionnaires three significant relationships were found. These relationships were associated with mercury/amalgam handling and skin contact, the number of amalgams placed by the dentist, and the number of hours of practice per week. The reported absence of a clear relationship between urinary mercury concentrations and potential kidney dysfunction is in agreement with other findings at the mercury concentrations tested.(ABSTRACT TRUNCATED AT 250 WORDS)
Efficacy of experimental dual-cure resin cement for orthodontic direct bond system (2006)

Chemical-cure resin cement has been widely used for orthodontics. To improve the clinical handling of chemical-cure resin cement, a dual-cure resin cement system composed of methyl methacrylate (MMA), urethane dimethacrylate (UDMA) and light activator was developed. The purpose of this study was to estimate the efficacy of an experimental dual-cure resin cement.A composite bracket was bonded to the teeth with one of eight resin cements: (1) Unifast II (Uni II); (2) Unifast II containing camphor quinone (Uni II-CQ); (3) Transbond XT (TB); (4) Orthomite Superbond (SB); (5) Unifast LC (Uni-LC); (6–8) experimental dual-cure resin cement—Exp1, Exp2 and Exp3, respectively. Shear bond strength (SBS) of all of the bonded brackets was measured after the cementation.The data were statistically divided, the highest cement (Uni-LC), the next group (Exp1, Exp2, Exp3 and SB) and the lowest group (Uni II, Uni II-CQ and TB).The dual-cure resin cement exhibited a bonding efficacy comparable to that of Superbond.
Diurnal Variation of Markers for Cholesterol Synthesis, Cholesterol Absorption, and Bile Acid Synthesis: A Systematic Review and the Bispebjerg Study of Diurnal Variations (2019)

Human studies have shown diurnal rhythms of cholesterol and bile acid synthesis, but a better understanding of the role of the circadian system in cholesterol homeostasis is needed for the development of targeted interventions to improve metabolic health. Therefore, we performed a systematic literature search on the diurnal rhythms of cholesterol synthesis and absorption markers and of bile acid synthesis markers. We also examined the diurnal rhythms of the cholesterol synthesis markers lathosterol and desmosterol, and of the cholesterol absorption markers cholestanol, campesterol, and sitosterol in serum samples from the Bispebjerg study. These samples were collected every three hours over a 24-hour period in healthy males (<i>n =</i> 24) who consumed low-fat meals. The systematic search identified sixteen papers that had examined the diurnal rhythms of the cholesterol synthesis markers lathosterol (<i>n =</i> 3), mevalonate (<i>n =</i> 9), squalene (<i>n =</i> 2), or the bile acid synthesis marker 7α-hydroxy-4-cholesten-3-one (C4) (<i>n =</i> 4). Results showed that lathosterol, mevalonate, and squalene had a diurnal rhythm with nocturnal peaks, while C4 had a diurnal rhythm with daytime peaks. Furthermore, cosinor analyses of the serum samples showed a significant diurnal rhythm for lathosterol (<i>cosinor p</i> < 0.001), but not for desmosterol, campesterol, sitosterol, and cholestanol (<i>cosinor p</i> > 0.05). In conclusion, cholesterol synthesis and bile acid synthesis have a diurnal rhythm, though no evidence for a diurnal rhythm of cholesterol absorption was found under highly standardised conditions. More work is needed to further explore the influence of external factors on the diurnal rhythms regulating cholesterol homeostasis.
Experimental Testing of the Quarter-Scale Rocket Chair (2005)

The rocket chair is a rocket-powered flight vehicle that launches a passenger to an altitude of a few thousand feet on a parabolic flight trajectory. A three-phase test flight program was conducted using one-eight-scale and quarter-scale models of the rocket chair to test aerodynamics, stability, and control characteristics. The aerodynamic drag coefficient was obtained for a wide range of Reynolds numbers. Additionally, an electronic pitch stability augmentation system was developed, flight tested, and evaluated for use on a full-scale rocket chair. The general flying qualities of the rocket chair have been found to be acceptable.