gebhart/patrepeval huggingface dataset:
Über den Einfluss des vom normalen abweichenden Blutdruckes auf die Resorption des Natriumsalicylates vom Muskel aus (1937)

Um die Frage, welchen Einfluss der vom normalen abweichenden Blutdruck auf die Resorption des Natrinrnsalicylates voran Muskel aus ausübt, zu beantworten, hat Verfasser eine Reihe von Versuchen an Kaninchen vorgenommen, deren Blutdruck durch Ephedrinhydrochlorid gesteigert bezw. durch Natriumnitrit, durch Durchschneidung des Rückenmarkes zwischen dem Lund dem 2. Halswirbel, durch Durchschneidung der beiderseitigen Splanchnici oder durch Blutentnahme (10 ccm pro Kilo Körpergewicht) herabgesetzt worden war. Bei diesen Versuchen wurde in den M. rectus femoris dext. 1, 0 ccm einer 10 % igen Lösung von Natriumsalicylat pro Kilo körpergewicht eingespritzt und dann die im Blutserum vorhandene Salicylsäurekonzentration 5, 15, 30 Minuten, 1, 1½, 2½, 3½, und 5 Stunden nach der Injektion mittels der von Ogawa modifizierten Hérisseyschen Methode bestimmt. Das Ephedrinhydrochlorid (1, 0 ccun der 2 % igen Lösung pro Kilo Körpergewicht) wurde 5 Minuten vor und 1½ Stunden nach der Salicylatinjektion also zweimal und Natriunnnitrit (1, 0 cern der 5 % igen Lösung pro Kilo Körpergewicht) 5 Minuten vor Salicylatinjektion also nur einmal in den M. rectus femoris sin. injiziert. Die Rückenmarks und Splanchnikusdurchschneidung wurden unmittelbar vor der Salicylatinjektion ausgeführt. Die Resultate sind zusammengefasst wie folgt: Der durch Ephedrin gesteigerte Blutdruck führt zu deutlich beschleunigter Salicylatresorption vom Muskel aus, der durch Natriumnitrit, Rückenmarks bezw. Splanchnikusdurchschneidung oder Blutentnahme herabgesetzte Blutdruck zu verzögerter. Diese Resorptionsverzögerung ist bei Rückenmarksdurchsehneidung sehr stark, ziemlich schwächer bei der Nitritapplikation sowie Splanchnikusdurchschneidung und noch etwas schwächer bei der Blutentnahme. Es ist noch zu bemerken, dass bei der Resorptionsförderung der Salicylsäuregehalt im Blutserum 30 Minuten nach der Salieylatinjektion das Maximum erreicht und 1 Stunde postinjektionem ziemlich abgenommen hat, während er bei der Resorptionsverzögerung zwar ebenfalls 30 Minnten nach der Injektion seinen maximalen Wert zeigt, der aber noch eine halbe Stunde lang anhält. [Vgl. Original (japanisch) S. 59.]
ChemInform Abstract: DIE SYNTH. UND DIE UNTERSUCHUNG DER BAKTERICIDEN AKTIVITAET BEI HEXAMETHYLENIMMONIUMDERIVATEN VON 2,5‐DIHALOGENTHIOPHENOLEN (1972)

Abstract Die aus den entsprechenden Sulfochloriden durch Reduktion mit Zink und Mineralsäuren dargestellten Thiophenole (I) werden durch Umsetzung mit Natrium in die Natriumthiophenolate (II) umgewandelt und mit β‐Chloräthylhexamethylenimin (III) kondensiert.
CCDC 1014178: Experimental Crystal Structure Determination (2014)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Abstract 4638: Anti-tumor activity of pimasertib in combination with SAR245409 or SAR245408 in human primary colorectal cancer xenograft models bearing PI3K/KRas and KRas mutations. (2013)

Abstract The PI3K/AKT/mTOR and Ras/Raf/MEK/ERK are interlinked growth and survival signaling pathways that are often constitutively activated in human tumors as a result of amplifications and/or mutations in PIK3CA, RAS and BRAF genes. In the present work, we have investigated the anti-tumor activity and documented the steady state pharmacodynamic impact of combinations between 2 selective pan PI3K Class I inhibitors, SAR245408 (XL147) and SAR245409 (XL765) with the selective allosteric inhibitor of MEK1/2, pimasertib (AS703026; MSC1936369B) against several different patient derived colorectal cancer (CRC) xenograft models harboring either KRAS mutations, dual KRAS and BRAF mutations or dual KRAS and PIK3CA mutations. In the BRAF driven CRC model, effects of the combinations were not significantly different from that of single agent treatment of pimasertib alone. In the G12V KRAS or G12D KRAS mutant CRC models, both combinations led to significantly greater anti-tumor activity than that of single agent treatment. In the dual PIK3CA/KRAS mutant tumors, combination therapies lead to a potent inhibition of both TORC1 and TORC2 pathways, in addition to inhibition of the MAPK pathway in contrast to single agent treatments. Overall, pimasertib combined with either SAR245409 or SAR245408 showed a significantly greater anti-tumor activity as compared to single agent treatment alone in primary models bearing KRAS mutations or dual PIK3CA/KRAS mutations. The combination of pimasertib and SAR245409 is currently being investigated in patients with PIK3CA/KRAS mutant colorectal cancer as part of an ongoing Phase Ib dose escalation trial of oral combination therapy with pimasertib (MSC1936369B) and SAR245409 in subjects with locally advanced or metastatic solid tumors. Citation Format: Sukhvinder S. Sidhu, Coumaran Egile, Marc Malfilatre, Celine Lefranc, Yvette Ruffin, Jianguo Ma, Karl Hsu, Joanne Lager, Stephane Marzabal, Janet A. Ogden, Loic Vincent. Anti-tumor activity of pimasertib in combination with SAR245409 or SAR245408 in human primary colorectal cancer xenograft models bearing PI3K/KRas and KRas mutations. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4638. doi:10.1158/1538-7445.AM2013-4638
MMPI Scale Scores Tested at the Time of Entrance into Medical School Its Lesser Use for the Prediction of the Future Repeater (1997)

We tested students with MMPI tests on their entrance into medical school, and tried to find the current features of scale scores of the tests as compared with the Japanese reference values obtained more than 25 years before. Since the data consisted of responses for two Japanese language translation versions of the tests we stratified the data by version, sex and calendar year, respectively and calculated means and standard deviations of 14 scale scores in each stratum. By comparing with the mean values of standard population, we found lower Si and higher K scores in both male and female, and significant differences in Mf scores between male and female students. On the other hand, we found neither differences due to temporal trends nor differences between versions of the test. More importantly, we were unable to find differences between successful students and those who had had to repeat a year. Indeed, correct predictions, using a linear discriminant function based upon seven of the scales, were only 60% in male and 64% in female students, respectively. Now, when we used a simple assumption as the diagnostic rule-that no students repeated-then 64% of male and 83% of female students were correctly classified; a result superior to the discriminant function rule. However, by using a different linear discriminant function, with variables selected directly from 550 unit items of MMPI test battery, we were able to attain marginally better separation than the simple rule, but for male students only. In conclusion, it is difficult to obtain a practical prediction rule using MMPI scale scores, even though use of the unit items of MMPI might improve accuracy of predictions.
Molecular mechanics study of the interaction of molybdenum disulfide layers with a γ-alumina support in hydrotreating catalysts (1996)

The non-bonded interactions of MoS2 slabs supported on γ-Al2O3, which are the active phase of a hydrotreatment catalyst, have been modelled by molecular mechanics. Free MoS2 sheets, containing 39 molybdenum atoms, have been used to test the reliability of the force field.The edge MoS2 planes and the support surfaces have been ideally modelled in order to investigate the influence on energy of geometrical parameters such as the orientation of the MoS2 layered cluster on γ-Al2O3 or the distance between the support and the MoS2 slabs. Whatever the support surface, a single MoS2 slab lying flat on the support is more stable than a slab perpendicular to the support, however, the energy difference between these two configurations decreases as the number of stacked MoS2 sheets increases.The energy of the interactions between two contiguous layers or between a sheet and the exposed surface of the support shows that single sheets lying flat are favoured on the [111] plane whereas the [110] plane induces a stacking of several slabs. The intercalation of one layer between a slab and the support or between two contiguous MoS2 slabs leads to a screen effect, characterized by a decrease of about two orders of magnitude in the interaction energy of the separated surfaces. This effect increases with the number of inserted sheets.
Psychologic Testing in Amputation Rehabilitation (1988)

Sixty adult patients had psychologic testing following successful below- or above-knee amputation surgery. All were considered to be prosthetic candidates based on the evaluation of an experienced multidisciplinary rehabilitation team. Objective psychologic testing revealed that six (10%) had severe deficits in cognitive ability, eight (13%) had covert psychiatric illness, and three (5%) had both. A vigorous attempt at prosthetic limb fitting and gait training was made in every patient in an inpatient rehabilitation unit. Of the 17 patients (28%) who were determined to be poor candidates for prosthetic limb fitting and gait training based on objective psychologic testing, only four (6%) were capable of even minimal use of the prosthesis, and none approached their preamputation level of ambulation. Psychologic testing may play an important role in determining the rehabilitation potential of the dysvascular amputee.
Antigen receptors and adhesion molecules on T lymphocytes in the gut (1991)

The gut-associated lymphoid tissue represents an important site of initial contact with foreign antigens from the intestinal lumen. It is a complex immune system comprising of Peyer's patches, mesenteric lymph nodes, mucosal lymphocytes present in the lamina propria, and intraepithelial lymphocytes located on the luminal surface of the basement membrane and adjacent to the basolateral side of enterocytes. The function and immunoregulation of the gut-associated lyphoid tissue and its role in the pathogenesis of intestinal diseases are only partly understood. We summarize selected advances in understanding the cell-surface molecules involved in homing and adhesion of T cells in the gut-associated lymphoid tissue and the nature of the T-cell antigen receptor repertoire expressed by intraepithelial lymphocytes.
Excimer fluorescence of dinucleotides, polynucleotides, and DNA. (1966)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Oestrogenicity of prenylflavonoids from hops: activation of pro‐oestrogens by intestinal bacteria (2009)

For many centuries, hops (Humulus lupulus L.) have been used as essential ingredient in beers, providing the typical bitterness and hoppy flavour. However, the last few years the plant has gained increasing attention as a source of prenylflavonoids and in 1999, 8-prenylnaringenin (8-PN) was identified as the most potent phyto-oestrogen known so far. Hop extracts are therefore now marketed to reduce menopausal complaints. However, 8-PN concentrations in hops are very low, and variable efficiency of these extracts was observed. Yet, hops also contain isoxanthohumol (IX) in much higher amounts (IX/8-PN ratio in hop extracts is typically 10-20). This article reviews our recent findings on how the human intestinal microbiota may activate IX. Depending on inter-individual differences in the intestinal transformation potential, this conversion could easily increase the 8-PN exposure 10-fold. The variability in efficacy of hop extracts may therefore be explained by variable intestinal metabolism. Based on this scientific knowledge, an innovative strategy was developed to decrease this variability. First, Eubacterium limosum, capable of rapidly metabolizing all IX into 8-PN, was isolated from the complex intestinal ecosystem. This bacterium was then used to develop a new generation of hop products with increased reliability in effect. This strategy involves the use of the bacterium as probiotic, in which the bacterium is administered in combination with the original hop extract. This leads to efficient intestinal 8-PN production, also in individuals who originally did not harbour the appropriate bacteria. The findings presented in this review can therefore be considered as a typical example that good insight in the specific metabolic potential of complex microbial communities and individual bacterial species may offer important opportunities for the management and modulation of the microbial organization towards a certain metabolic function.
ChemInform Abstract: Synthesis and Electro‐Optical Properties of Novel Liquid Crystals Having a Cyclohexyl Trifluoromethyl Ether Moiety. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optical clock recovery for high-speed optical networks (2002)

A novel inline optical clock recovery circuit, based on the periodic oscillations that result from the astable behavior of a bistable optical device with delayed feedback, is described. Clock extraction from an intensity modulated 13.6-Mb/s return-to-zero (RZ) optical data stream is demonstrated. Operation at much higher speed can be achieved by monolithic integration. The circuit is based on an integrated-optic modulator with delayed feedback. The incoming optical data signal is added to a constant optical bias before entering the modulator. Part of the light, transmitted through the modulator, is photodetected; the resulting electrical signal is amplified and then fed back to the electrical input of the modulator after an electrical bias has been added to it. With only the constant optical input, the output signal is a continuous square-wave oscillation whose period is determined by the time delay tau introduced by the feedback loop.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development of a hybrid helical microwiggler with four poles per period (2003)

A compact strong test hybrid helical microwiggler has been designed and developed with ten periods, each with length 10 mm and four poles, and gap diameter of 5 mm. One period is constructed with four segments. Each segment has a thickness of 2.5 mm and consists of pentagonal permanent magnets and permendur poles. Each segment is stacked along the wiggler axis and is rotated by an angle of 90° to the adjacent segment. The outer width is only 72 mm. The wiggler is divided into two sections where two kinds of permanent magnet - one with apex angle of 90° and one with 120° - were installed in order to find out the effect of geometrical size for the field. Peak fields of 0.360 and 0.381 T were achieved with small rms variations of about 1.1% and 0.6%, respectively, depending on the geometrical size of the permanent magnet.
Synthesis of the Major Bacteriophage f1 Coat Protein (1971)

A method which allows one to follow the synthesis of the major f1 coat protein in normal, unirradiated f1-infected cells is reported. The N -terminal tryptic peptide of this protein, labeled with 14 C-lysine, has a negative charge at p H 4.5 and is readily separated from the contaminating peptides of host cell proteins. This technique was used to study several aspects of the synthesis of the major f1 coat protein in infected cells.
Superconductivity in La<sub>1.85-x</sub>Nd<sub>x</sub>Sr<sub>.15</sub>CuO<sub>4</sub> (1987)

The effect of magnetic impurities on the high T c superconductor La 1.85 Sr .15 CuO 4 was investigated by replacing La with Nd. We find a depression of T c and dH c2 /dT with increasing Nd concentration which does not follow predictions of the pairbreaking effects due to magnetic impurities. We attribute our experimental results to a density of states effect.
PD51-04 ACTIVE SURVEILLANCE FOR LOCALIZED RENAL MASSES: GROWTH RATES AND OUTCOMES IN PATIENTS WITH MASSES ≥4 CM (2018)

INTRODUCTION AND OBJECTIVES: Conditional survival can provide guidance for patients once they have survived a period of time after diagnosis of their disease. We determine conditional survival for patients with small renal masses (SRM) undergoing active surveillance (AS).
OP14.03: Assessing the performance of the examination of intracranial translucency and posterior fossa anatomy for the first trimester detection of spina bifida (2012)

To estimate the detection rate (sensitivity) and specificity of the evaluation of intracranial translucency (IT) and detailed analysis of posterior fossa anatomy for detection of spina bifida at the 11–13-week scan and to compare the estimates for trained and untrained observers. A retrospective analysis of 260 images of first trimester nuchal translucency (NT) routine scans, including a random sample of 208 normal foetuses and 52 cases of spina bifida cases was conducted. Four observers reviewed the images. Observer 1 (the “insider”) had already seen once the affected foetuses images before they were mixed with the normal images. Observers 2 and 3 had had specific training for IT screening, and observer 4 did not receive any specific training. The analysis focussed on the visualisation of (i) the IT (fourth cerebral ventricle), (ii) the cisterna magna (CM), and (iii) the mesencephalon posterior tilt (MPT). The detection rate (DR) and the specificity of each sign (IT, CM, MPT) and of an abnormal result in one of the three were calculated with 95% binomial exact confidence intervals for each observer. DR for non-visualisation of IT varied from 28.8 to 48.1%. DR for non-visualisation of CM had a range from 50.0 to 73.1%. DR for MPT visualisation had a range from 20.0 to 85.7%. Overall, the DR rose to 50.0–90.4% when at least one of the three signs was present. The highest DR for observers 2, 3 and 4 was for the CM visualisation (50.0, 73.1 and 57.7%, respectively). The untrained observer had an intermediate DR for all criteria, between the “insider” and the two other trained observers The Sp estimates were similar for the observers and across the different criteria, with a range of 82.7 to 98.1%. We found that non-visualisation of CM had the highest DR for spina bifida, for both trained and untrained observers. The MPT may be too subjective to be used for screening. Together, CM and IT achieve the highest DR for spina bifida at the 11–13-week scan.
A case of adjuvant disease of man associated with myopathy showing sarcoid-like lesion due to mammoplasty (1987)

20年前に受けた乳房形成術(シリコン)後に発症したと考えられる,サルコイド様病変を有する人adjuvant病の1例を経験した.症例は41才,女性.嚥下障害,下肢脱力,易疲労感を主訴として入院.顔面に米粒大以下の紅斑～丘疹,下肢筋力低下があり,両側乳房内に硬い超鶏卵大腫瘤が触知された.血中CK, aldolase,尿中creatine値が高く,筋電図上myogenic patternが認められた.摘出されたシリコン周囲,皮疹,下肢筋にはサルコイド様結節が認められ,血中angiotensin変換酵素(ACE)とリゾチーム活性も高値なことより,サルコイド様病変と考えられる.乳房形成術後の人adjuvant病で筋炎(サルコイド様病変)を伴った例は,本例が最初と考えられる.
Mesure interférométrique des vibrations des résonateurs à quartz horlogers (1983)

OPT
Different patterns of myometrial activity and 24-h rhythms in myometrial contractility in the gravid baboon during the second half of pregnancy (1992)

Two clearly distinct epochs of myometrial contractility were observed in 13 pregnant baboons when recorded either as intraamniotic pressure (IAP) or myometrial electromyogram (EMG). Contractures, epochs lasting longer than 3 min, were the characteristic form of myometrial activity throughout pregnancy. Contractures generated only small increases in IAP. Short-lived contractions, generating larger increases in IAP, were characteristic of labor and delivery. Power spectral analysis of IAP and myometrial EMG activity proved to be an effective means whereby periods when the myometrium was in the contractures or contractions mode could be easily distinguished. Concomitantly recorded maternal intraabdominal temperature showed significant 24-h variations. When myometrial activity switched from low-amplitude, long-lasting regular contractures of pregnancy to contractions, the switch always occurred around the onset of darkness. Five baboons went into spontaneous labor, 3 prematurely and 2 at term. In these animals the switch from contractures to contractions occurred for several nights before delivery. The recurrence and timing of the switch from contractures to contractions for several nights before delivery were similar to the pattern we and others have observed in the pregnant rhesus monkey. The presence of 24-h periodicity in the patterns of specific types of myometrial activity in another nonhuman primate lends support to the view that similar 24-h patterns of myometrial activity may occur in pregnant women.
Polymerization of <i>N</i>‐phenylmaleimide with organozinc compounds as initiators (1987)

Abstract The polymerization of N ‐phenylmaleimide (N‐PMI) was carried out with organozinc compounds as initiators. Within the initiators examined [Zn(OCH 3 ) 2 ·(C 2 H 5 ZnOCH 3 ) 6 ] gave the highest yield of poly(N‐PMI). The polymer yield increased rapidly at the early stage of the polymerization reaction. The poly(N‐PMI) produced shows a unimodal molecular weight distribution in the high‐molecular‐weight region and two components in the oligomeric region in GPC. 1 H NMR and 13 C NMR spectra suggest an addition polymerization without any remarkable side reactions. The results of the copolymerization with styrene and of the polymerization in nitrobenzene suggest an ionic polymerization mechanism.
Compensation of corneal aberrations by the internal optics in the human eye (2001)

The objective was to study the relative contribution of the optical aberrations of the cornea and the internal ocular optics (with the crystalline lens as the main component) to overall aberrations in the human eye. Three sets of wave-front aberration data were independently measured in the eyes of young subjects: for the anterior surface of the cornea, the complete eye, and internal ocular optics. The amount of aberration of both the cornea and internal optics was found to be larger than for the complete eye, indicating that the first surface of the cornea and internal optics partially compensate for each other's aberrations and produce an improved retinal image. This result has a number of practical implications. For example, it shows the limitation of corneal topography as a guide for new refractive procedures and provides a strong endorsement of the value of ocular wave-front sensing for those applications.
The Mental Health Checkup by the On-line Mental Health Questionnaire and All the Members Direct Interview (2003)

NTT-IT社が作成したon-lineメンタルヘルス問診票を使い, NTT北陸地区職員を対象としたメンタルステートの評価を行い, かつ定期検診および人間ドック受診時に全員を対象として直接個人面接を行い精神的な状況を把握した。On-line問診票の感度および特異度は高く, かつ大部分の受診者は自分への問診票の回答を見て満足していた。直接面接でうつ状態やうつ病と考えられた受診者にはeメールや携帯型テレビ電話でのカウンセリングおよび心療内科クリニックへの受診を勧め期間中に8名が治療を受けた。