gebhart/patrepeval huggingface dataset:
Reciprocal changes in plasma corticosterone and testosterone in stressed male rats maintained in a visible burrow system: evidence for a mediating role of testicular 11 beta-hydroxysteroid dehydrogenase. (1994)

The purpose of these studies was to investigate the possible role of rat Leydig cell 11 beta-hydroxysteroid dehydrogenase (11HSD) in mediating the inhibitory effects of corticosterone on testosterone production. In a unique communal environment, the visible burrow system, male Long-Evans rats spontaneously segregated into unstressed dominant and stressed subordinate social relationships. Subordinate animals had elevated plasma corticosterone and diminished circulating testosterone levels relative to the dominant animals. The categories of animals were distinguished by behavioral criteria: weight change, wounds received, offensive and defensive behavior, and freedom of movement. As a result of their persistently elevated corticosterone levels, subordinate animals had smaller thymi and larger adrenals and spleens than dominants. We have postulated that Leydig cells are protected against the inhibitory effects of glucocorticoids on testosterone secretion by the inactivating effects of 11HSD. High corticosterone and low 11HSD are predicted to suppress testosterone production, and normal or diminished corticosterone levels combined with normal or elevated 11HSD should permit undiminished testosterone production. Consistent with these predictions, the testes of subordinate animals contained significantly lower 11HSD activity than those of dominant animals. The 11HSD of livers of subordinate and dominant animals were statistically indistinguishable. The results of this study support the postulated role of 11HSD as a protector of Leydig cell function.
Suppression of natural killer cell-mediated bone marrow cell rejection by CD4<sup>+</sup>CD25<sup>+</sup>regulatory T cells (2006)

Naturally occurring CD4(+)CD25(+) T regulatory (Treg) cells have been shown to inhibit adaptive responses by T cells. Natural killer (NK) cells represent an important component of innate immunity in both cancer and infectious disease states. We investigated whether CD4(+)CD25(+) Treg cells could affect NK cell function in vivo by using allogeneic (full H2-disparate) bone marrow (BM) transplantation and the model of hybrid resistance, in which parental marrow grafts are rejected solely by the NK cells of irradiated (BALB/c x C57BL/6) F(1) recipients. We demonstrate that the prior removal of host Treg cells, but not CD8(+) T cells, significantly enhanced NK cell-mediated BM rejection in both models. The inhibitory role of Treg cells on NK cells was confirmed in vivo with adoptive transfer studies in which transferred CD4(+)CD25(+) cells could abrogate NK cell-mediated hybrid resistance. Anti-TGF-beta mAb treatment also increased NK cell-mediated BM graft rejection, suggesting that the NK cell suppression is exerted through TGF-beta. Thus, CD4(+)CD25(+) Treg cells can potently inhibit NK cell function in vivo, and their depletion may have therapeutic ramifications for NK cell function in BM transplantation and cancer therapy.
Sculptured thin film Solc filters for optical sensing of gas concentration (1999)

The viability of sculptured thin film (STF) implementations of Šolc fan and folded filters for optical detection and determination of gas concentration is established. A nanoscopic–to–continuum model is devised for predicting the electromagnetic (optical) response of a STF Šolc filter whose void regions are filled with a chemically non–reacting gas. Ultra–narrow band–pass features in the transmission spectrum are shown to shift with the gas concentration.
Reviews (1955)

“MUST WE LOSE AFRICA?” by Colin Legum. (Allen, London) pp. 264: 16/ stg. ANCIENT FOUNDATIONS OF ECONOMICS IN INDIA, by K. T. Shah, Bombay, 1954. Pp. 175. THE PROSPECTS FOR COMMUNIST CHINA, by W. W. Rostov, in collaboration with Richard W. Hatch, Frank A. Kierman, jun., and Alexander Eckstein. Technology Press and John Wiley & Sons, New York, 1955. Pp. xx plus 379. $5.00.
Continuous Micro-Production Using Enzymatic Reaction and Online Monitoring (2010)

A micro-reactor coupled to a microfluidic system and an online UV/VIS spectrometer is described. The enzymatic reaction studied is the hydrolysis of the N-benzoyl-L-tyrosine ethyl ester (BTEE) to N-benzoyl-L-tyrosine (BT) and ethanol, catalyzed by chymotrypsin. The production is online monitored with UV spectroscopy at 256 nm. Three different immobilization methods of the enzyme are discussed: Eupergit C, controlled-pore glass (CPG), and Sepharose.
Prevention of glutaraldehyde-fixed bioprosthetic heart valve calcification by alcohol pretreatment: further mechanistic studies. (2000)

Glutaraldehyde storage after ethanol pretreatment aggravates calcification; moreover, alcoholic-glutaraldehyde crosslinking solutions are not beneficial for anti-calcification. Ethanol pretreatment of glutaraldehyde-pretreated bovine pericardium prevents its calcification.
Isolation of autophagocytosis mutants of <i>Saccharomyces cerevisiae</i> (1994)

Protein degradation in the vacuole (lysosome) is an important event in cellular regulation. In yeast, as in mammalian cells, a major route of protein uptake for degradation into the vacuole (lysosome) has been found to be autophagocytosis. The discovery of this process in yeast enables the elucidation of its mechanisms via genetic and molecular biological investigations. Here we report the isolation of yeast mutants defective in autophagocytosis (aut mutants), using a rapid colony screening procedure.
Waveguide structure based tabletop electron acceleration setup using THz pulses (2020)

In our numerical simulations the acceleration of electron bunches in THz pulse-driven waveguide structures has been investigated. Acceleration of electron bunches with 1fC bunch charge up to 46 keV energy was predicted at 50 mm.
Tip- and Laser-based 3D Nanofabrication in Extended Macroscopic Working Areas (2021)

Abstract The field of optical lithography is subject to intense research and has gained enormous improvement. However, the effort necessary for creating structures at the size of 20 nm and below is considerable using conventional technologies. This effort and the resulting financial requirements can only be tackled by few global companies and thus a paradigm change for the semiconductor industry is conceivable: custom design and solutions for specific applications will dominate future development (Fritze in: Panning EM, Liddle JA (eds) Novel patterning technologies. International society for optics and photonics. SPIE, Bellingham, 2021. 10.1117/12.2593229 ). For this reason, new aspects arise for future lithography, which is why enormous effort has been directed to the development of alternative fabrication technologies. Yet, the technologies emerging from this process, which are promising for coping with the current resolution and accuracy challenges, are only demonstrated as a proof-of-concept on a lab scale of several square micrometers. Such scale is not adequate for the requirements of modern lithography; therefore, there is the need for new and alternative cross-scale solutions to further advance the possibilities of unconventional nanotechnologies. Similar challenges arise because of the technical progress in various other fields, realizing new and unique functionalities based on nanoscale effects, e.g., in nanophotonics, quantum computing, energy harvesting, and life sciences. Experimental platforms for basic research in the field of scale-spanning nanomeasuring and nanofabrication are necessary for these tasks, which are available at the Technische Universität Ilmenau in the form of nanopositioning and nanomeasuring (NPM) machines. With this equipment, the limits of technical structurability are explored for high-performance tip-based and laser-based processes for enabling real 3D nanofabrication with the highest precision in an adequate working range of several thousand cubic millimeters.
Angiotensin converting enzyme inhibition and coronary artery disease (1994)

ACE inhibitors prevent the development of atherosclerosis in hyperlipidemic animal models. They also prevent the myointimal proliferative response to injury in some animal models, but not in higher animal species or in humans. They can reduce the number of cardiac ischemic events in patients with coronary artery disease and left ventricular dysfunction; their effects in those patients with a normal left ventricular function are now being assessed.
Isolation and characterization of ovine IGFBP-4: protein purification and cDNA sequence (1994)

Three different molecular mass forms of IGF-binding proteins (IGFBPs) were purified from ovine plasma by IGF-I affinity chromatography and reverse-phase HPLC: a 46 kDa doublet and 29 kDa and 24 kDa forms. Amino-terminal sequence analysis confirmed that these proteins were ovine (o)IGFBP-3 (46 kDa) and two molecular size variants of oIGFBP-4. oIGFBP-3 and the 29 kDa form of oIGFBP-4 were shown to be N-glycosylated. Isoelectric points were determined to be at approximately pH 6 for oIGFBP-3 and at pH 7 and pH 7.5 for the 29 and 24 kDa forms of oIGFBP-4 respectively. The two different molecular mass variants of oIGFBP-4 had similar IGF-binding properties. Compared with human IGFBP-3 and oIGFBP-3, the two variants of oIGFBP-4 exhibited lower relative binding to amino-terminally modified IGF-I analogues in a competitive IGF-binding assay. The full protein sequence of oIGFBP-4, as deduced from the cDNA sequence, showed a high degree of identity with rat (90%), human (96%) and bovine (98%) IGFBP-4. The cDNA sequence also showed homology over regions of the 3' non-coding sequence, particularly in comparison with bovine IGFBP-4 (96%). Northern analysis of mRNA for oIGFBP-4 indicated a 2.6 kb major transcript and two minor transcripts of approximately 2.1 and 1.8 kb. oIGFBP-4 mRNA transcripts were detected in adult ewe liver > kidney > lung >> heart and also in several fetal tissues, thus suggesting tissue-specific and developmental regulation. The availability of purified oIGFBP-4 and oIGFBP-3 as well as DNA probes for oIGFBP-4 will enable further study of the properties and functions of these proteins, as well as the establishment of specific assays for these IGFBPs.
Chiral Alkynyl Products by a Sulfinate-mediated Approach with Allenyl Sulfones: a Modified Padwa Reaction (2016)

International audience
New insights into the Cu<sup>+</sup>‐assisted nucleophilic radioiodination of bromopyridine and iodopyridine analogues (2012)

The Cu + method, originally developed for aromatic compounds, has also been applied for radioiodination of pyridine rings. The aim of this paper is a more fundamental approach of the different parameters ruling the Cu + ‐assisted radioiodination of the regiomers of pyridine. A mechanistic model is represented on the basis of the mutual complex‐formation properties of pyridine for Cu + and Sn ++ . It is proven that a part of the Cu + catalyst, required for optimal labelling, is involved in a Halo‐PyrN:Cu + ‐complex resulting in a lower labelling yield. In case of 3‐Br‐pyridine and 4‐Br‐pyridine, the Sn ++ present in excess versus Cu + in the general reaction conditions, can displace Cu + from its pyridine complex rendering it available as catalyst, allowing a successful labelling. A 2‐Br‐pyridine, with the halogen atom in ortho position of the N atom, is an exception to that rule: the Cu + ions reversibly bound in the Br‐Pyr‐N:Cu + ‐complex are also involved in an intramolecular transfer to the ortho C‐Br bond resulting in an effective molarity exceeding the bulk concentration and a high labelling yield. Radioiodination of a 2‐halo‐pyridine analogue is preferentially performed in the absence of SnSO 4 , using only gentisic acid as reducing agent. Copyright © 2012 John Wiley & Sons, Ltd.
<title>Mechanism of read-instability of optical recording</title> (1990)

Numerical analysis of the heat propagation shows an important role of the adhesion of recording layer and plastic substrate of optical recording media. Poor adhesion leads to the delamination of recording layer and causes the irreversible deformation of substrate. This explains the irreversible decrease of read back signal by continuous laser beam.
Millimeter-wave self-heterodyne transmission technique and a si m pl e m i I I i mete r-wave divers ity - rece pt ion system (2002)

We introduce a millimeter-wave self-heterodyne transmission technique and a simple system that provides diversity in reception. Millimeter-wave oscillators with higher levels of phase-noise and frequency offset are relatively cheap; the technique allows the use of such oscillators in millimeter-wave communications systems regardless of the modulation format because the effects of the oscillator are canceled at the receiver. Applying this technique thus provides extremely stable and low-phase-noise transmission as well as a lower-cost millimeter-wave communications system. We also show that t he use of millimeter-wave self-heterodyning is applicable to the cost-effective creation of easy-to-handle combining-diversity reception systems and that an extra-CNR margin of 3 dB can be obtained by the two-branch structure for diversity in reception. I Introduction and principle of operation Millimeter-wave bands with their very large bandwidths have now become available. Wireless communications systems that operate in this band may lead to the transmission of larger capacities and the ' hrther miniaturization of equipment. However, the phase-noise and frequency offsets that are introduced by the millimeter-wave local oscillators cause serious problems with the signal quality of millimeter-wave communications systems. Measures to suppress these effects lead to increased costs of production. To cost-effectively solve these problems, we have proposed and developed a form of self-heterodyning for millimeter-wave communications ( 1-31. The hndamental system configuration is shown in Fig. 1. The transmitter sends the millimeter-wave RF signal and local carrier in a millimeter-wave band, i.e., the received signal for the millimeter-wave self-heterodyning is expressed as r(t) = Refrc(t)f = Re ((ms(l)d2';' + @) e'(znAr+8(')1 (1) P where f; and 0 (t) are the frequency and phase-noise terms of the local oscillator, respectively. This signal is detected at the receiver by using a square-law detector . r' (t) = -Re { r, (t)r, (t)} +-Re{ r, (r)r,* (t)) 1 1
Separatory Flask and Beaker (1996)

Separatory funnels are commonly used in the organic laboratory for separating organic and aqueous layers after extraction. We designed an alternative by adding a pouring sidearm to an Erlenmeyer flask or beaker that is described in this article.
Computational analysis of non-adherence and non-attendance using the text of narrative physician notes in the electronic medical record (2007)

Non-adherence to physician recommendations is common and is thought to lead to poor clinical outcomes. However, no techniques exist for a large-scale assessment of this phenomenon. We evaluated a computational approach that quantifies patient non-adherence from an analysis of the text of physician notes. Index of non-adherence (INA) was computed based on the number of non-adherence word tags detected in physician notes. INA was evaluated by comparing the results to a manual patient record review at the individual sentence and patient level. The relationship between INA and frequency of Emergency Department visits was determined. The positive predictive value of identification of individual non-adherence word tags was 93.3%. The Pearson correlation coefficient between the INA and the number of documented instances of non-adherence identified by manual review was 0.62. The frequency of ED visits was more than twice as high for patients with INA in the highest quartile (least adherent) than for patients with INA in the lowest (most adherent) quartile (p < 0.0001). We have described the design and evaluation of a novel approach that allows quantification of patient non-adherence with physician recommendations through an analysis of physician notes. This approach has been validated at several levels and demonstrated to correlate with clinical outcomes.
HELIMAP: Digital imagery/Lidar handheld airborne mapping system for natural hazard monitoring. (2005)

Natural hazard occurs over inaccessible and extremely dangerous areas where standard mapping techniques are a misfit. Moreover, the rapidity of the intervention is a crucial aspect when natural catastrophe strikes. In such event the standard photogrammetry or classical airborne Lidar are usually not flexible enough to become operational in few hours. Originally developed for avalanche mapping, HELIMAP (www.helimap.com) is a portable mapping system for fast helicopter deployment. It integrates high accuracy navigation sensors (GPS/INS) with Airborne Laser Scanner (ALS) and 22Mpix digital (CCD) camera. The system can be mounted on most types of helicopters within minutes and offers autonomous 3D surface mapping (Digital terrain model-DTM and orthophoto) of any terrain (including snow) with decimetre-level accuracy up to 500m flying height above ground level. HELIMAP creation is a result of research carried out at the Swiss Federal Institute of Technology of Lausanne (EPFL) in the laboratories of Photogrammetry and Geodesy. The system’s flying services and expertise are provided by a small private company (UWR SA). The application field of the system spans from natural hazard mapping (avalanche mass balance, snow drift, debris flow volume, landslide, rockfalls, floods, etc.) to corridor applications (powerlines, rivers, roads, coast line, ect.) including large scale mapping over small areas. The paper presents the system concept and characteristics, its different modes of operation and synthesis of practical experiences.
Modulators of Urinary Stone Formation (2005)

No AccessJournal of UrologyUrological Survey: Urolithiasis, Endourology and Laparoscopy1 Feb 2005Modulators of Urinary Stone Formation Ralph V. ClaymanM.D. Ralph V. ClaymanRalph V. Clayman More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000149869.80976.9eAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Modulators of Urinary Stone Formation." The Journal of Urology, 173(2), p. 478 © 2005FiguresReferencesRelatedDetails Volume 173 Issue 2 February 2005 Page: 478 Advertisement Copyright & Permissions© 2005Metrics Author Information Ralph V. Clayman More articles by this author Expand All Advertisement PDF downloadLoading ...
Microstructural and Electrical Properties of (Ba x Sr 1 − x )Ti 1 + y O 3 + z Thin Films Prepared by RF Magnetron Sputtering (2002)

Abstract The electrical and microstructural properties of (Ba x Sr 1 m x )Ti 1+y O 3+z (BST) thin films prepared by RF magnetron sputtering were investigated as a function of deposition temperature over the range of 100 C to 650 C. Films deposited above approximately 350 C on Pt/TiO 2 /SiO 2 /Si substrates were polycrystalline with relative permittivites of 100 nm thick BST thin films varying from 100 at 350 C to 600 at 650 C. For deposition temperatures below approximately 350 C, the electrical properties were strongly influenced by the presence of a less crystalline BST layer. Films deposited at 250 C were comprised of a multilayer polycrystalline/less crystalline BST structure. The less crystalline BST layer strongly affected both measured dielectric permittivity and leakage properties. Leakage characteristics of Pt/BST(250C)/Pt capacitors exhibited a power law dependence on voltage or an exponential dependence on square root of the applied voltage depending on whether the top Pt electrode adjacent ot the polycrystalline BST layer was biased at a high or low electric potential, respectively. Mechanisms for the observed leakage behavior are discussed. Keywords: BstThin FilmsRf SputteringLow TemperatureScl
Imaging Redox Status Using Magnetic Resonance Techniques (2014)

酸化還元（レドックス）反応は様々な生体代謝反応を担い，ホメオスタシスの維持に重要な役割を果たしている．近年，生体レドックスバランス（生成系と防御系の均衡）の破綻が多くの疾患に関与することが明らかとなってきていることから，生体レドックス動態の可視化は病態の機序解明や薬効評価の指標としての役割を果たすことが期待されている．ニトロキシルラジカルは分子内に安定な不対電子（ラジカル）有し，電子スピン共鳴法（ESR）や核磁気共鳴画像化法（MRI）などの磁気共鳴法におけるレドックス応答造影剤として生体のレドックス動態を可視化するために活用されてきた．本稿では磁気共鳴画像化法を用いたレドックス動態の可視化についてこれまでの研究成果を紹介する．さらに現在開発を進めているレドックスモレキュラーイメージング（ReMI: redox molecular imaging）装置について最新の成果を紹介する．
LCM: An Efficient Algorithm for Enumerating Frequent Closed Item Sets. (2003)

In this pap weprH osethr# algor53fi) LCMfrM - LCM, and LCMmaxfor mining allfrfikk# t sets, frts,fi t closed item sets, and maximal frimal t sets, ret ectively,frW tr3WWfi)H#6 databases. The main theor3##6fi contrfi#k#k4 is that we constrfi) trst shapedtr3O# erO# rO#O composed of onlyfryfikH t closed item sets, which is induced by apar5 t-child rldfik3#kOfi) defined onfr#O#3 t closed item sets. By tr verk5H therefi# in adepth-firO manner LCM finds allfrfi36W t closed item sets in polynomial time per item set, without storut prutfi#OH obtained closed item sets inmemor .MorO ver we intr duce severfi algor5fi)## techniques using thespar# and densestrfi533#fi of input data.Algor6W54 for enumerk3 #k allfr#W43 t item sets and maximal frimal t item setsar obtainedfra LCM as its var#H ts. By computational experfi## ts onrfi# work and synthetic databases tocompar their per436fi)kO to the prefik3# algor#k#fi) we found thatour algor#H#fi ar fast onlarW rr worO datasets withnatur# distr -fik3##5 such as KDD-cup2000 datasets, and many other synthetic databases.
Synthetic and Degradative Investigations of the Structure of Folinic Acid-SF (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic and Degradative Investigations of the Structure of Folinic Acid-SFMargie May, Thomas J. Bardos, Frank L. Barger, Myra Lansford, Joanne M. Ravel, George L. Sutherland, and William ShiveCite this: J. Am. Chem. Soc. 1951, 73, 7, 3067–3075Publication Date (Print):July 1, 1951Publication History Published online1 May 2002Published inissue 1 July 1951https://pubs.acs.org/doi/10.1021/ja01151a028https://doi.org/10.1021/ja01151a028research-articleACS PublicationsRequest reuse permissionsArticle Views374Altmetric-Citations132LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Traffic Radar (1990)

Let us begin by making it clear that we are very strong advocates of the use of radar by police in speed limit enforcement. Without this particularly useful tool, it would be much more difficult to enforce some very important limits such as those associated with school zones. At the request of a local police force we have testified at a legislative hearing in opposition to a proposed law that would have limited the use of radar by police. However, we have also been involved in court situations in which we were prepared to state a professional opinion that the radar unit had been misused and that the speed reported on the citation was quite possibly inaccurate. In the bulk of this practice we see actual or possible litigation to resolve questions of responsibility for injury and/or property damage - that is, civil law. When we become involved in traffic radar questions we must remind ourselves that we are looking at criminal law and the rule is now one of reasonable doubt. Thus,