gebhart/patrepeval huggingface dataset:
Revenue-maximizing pricing and capacity expansion in a many-users regime (2003)

We consider a network where each user is charged a fixed price per unit of bandwidth used, but where there is no congestion-dependent pricing. However, the transmission rate of each user is assumed to be a function of network congestion (like TCP), and the price per unit bandwidth. We are interested in answering the following question: how should the network choose the price to maximize its overall revenue? To obtain a tractable solution, we consider a single link accessed by many users where the capacity is increased in proportion to the number of users. We show the following result: as the number of users increases, the optimal price per unit bandwidth charged by the service provider may increase or decrease depending upon the bandwidth of the link. However, for all values of the link capacity, the service provider's revenue per unit bandwidth increases and the overall performance of each user (measured in terms of a function of its throughput, the network congestion and the cost incurred by the user for bandwidth usage) improves. Since the revenue per unit bandwidth increases, it provides an incentive for the service provider to increase the available bandwidth in proportion to the number of users.
Introducing routing standby in network nodes to improve energy savings techniques (2012)

In this work we propose the routing standby model to save energy in an IP networks during low traffic hours. This model is based on the ability to put in standby mode all the IP processing functionalities of a network node. The main feature of this model is to save a great amount of energy, about the 50% of the total power consumption of a router, avoiding the drawback of a classical node standby, related to the removal of a node from the network. We also define a routing standby algorithm, based on the well-known Floyd-Warshall algorithm, able to detect a set of routing standby nodes so that traffic requirements are satisfied. The performance evaluation show that about the 50% of network routers can avoid IP operations when traffic decreases over 75% of peak value; in this way a remarkable energy saving can be obtained.
ENDOSCOPIC INTERNAL DRAINAGE VS. LOW NEGATIVE PRESSURE ENDOLUMINAL VACUUM THERAPY FOR LEAKAGES AFTER ONCOLOGIC UPPER GASTROINTESTINAL SURGERY (2020)

Aims Endoscopic internal drainage using pigtail stents (EID) serves as treatment option for leakages after upper GI oncologic surgery. Endoluminal vacuum therapy (EVT) also offers high closure rates and active therapy surveillance. Secretion drainage and mucosal irrigation are mechanisms of action. Both treatments have not been compared in larger studies.
Rotational molding cycle time reduction through surface enhanced molds: Part A—Theoretical study (2007)

Abstract Rotational molding has been regarded as a plastic molding method with great potential. The process offers virtually stress‐free products having no weld lines or material wastage, and utilizes relatively inexpensive molds. Yet its widespread growth is hindered due to long production cycle times, which are limited by the time required to heat up and cool down the mold and the product. To address this issue, efforts have been made to enhance heat transfer to and from molds, ultimately reducing cycle times. The application of extended and rough surfaces to molds is investigated here. The aim of this study is to predict reductions in cycle time due to the enhancement of mold surfaces (i.e. roughness‐enhanced and pin‐enhanced molds). By utilizing a combination of heat transfer correlations, numerical analysis, and an existing rotational molding process simulation, cycle time predictions were made. The average predicted cycle time reductions were ∼21 and 32% for the roughness‐enhanced and pin‐enhanced molds considered, under a variety of conditions. POLYM. ENG. SCI., 47:1406–1419, 2007. © 2007 Society of Plastics Engineers
Residue-specific global fluorination of <i>Candida antarctica</i> lipase B in <i>Pichia pastoris</i> (2010)

We report the in vivo fluorination of the tryptophan, tyrosine, and phenylalanine residues in a glycosylation-deficient mutant of Candida antarctica lipase B, CalB N74D, expressed in the methylotrophic yeast Pichia pastoris and subsequently segregated into the growth medium. To achieve this, a P. pastoris strain auxotrophic for all three aromatic amino acids was supplemented with 5-fluoro-L-tryptophan, meta-fluoro-(DL)-tyrosine, or para-fluoro-L-phenylalanine during expression of CalB N74D. The residue-specific replacement of the canonical amino acids by their fluorinated analogs was confirmed by mass analysis. Although global fluorination induced moderate changes in the secondary structure of CalB N74D, the fluorous variant proteins were still active lipases. However, their catalytic activity was lower than that of the non-fluorinated parent protein while their resistance to proteolytic degradation by proteinase K remained unchanged. Importantly, we observed that the global fluorination prolonged the shelf life of the lipase activity, which is an especially useful feature for the storage of, e.g., therapeutic proteins. Our study represents the first step on the road to the production of biotechnologically and pharmacologically relevant fluorous proteins in P. pastoris.
Effects of Milk Casein-derived Peptides on Absolute Oxyhaemoglobin Concentrations in the Prefrontal Area and on Work Efficiency after Mental Stress Loading in Male Students (2008)

This study examined the influence of milk casein-derived peptides on cerebral activity after mental stress loading. In a crossover study, 16 male students were given a drink containing peptides (peptide group), or water (control group) before stress loading. The oxyhaemoglobin (HbO(2)) concentration in the prefrontal area of the brain and work efficiency were measured as indicators of cerebral activity and differences in these parameters were examined according to type A or type B personality. Type A behaviour was defined as: aggression-hostility, hard-driving-time-urgency and speed-power, whereas type B behaviour did not have these characteristics. Peptide intake resulted in a significant increase in both HbO(2) concentration and work efficiency, whilst a similar increase was not seen in the control group. When divided into type A or type B personality, the changes in HbO(2) concentration for the control group differed significantly in the right prefrontal area. Moreover, in type A subjects the HbO(2) concentration in the right prefrontal area following intake was significantly different between the peptide and control groups.
Multi-criteria benchmarking of movement generating dynamical systems for learning-from-demonstrations (2014)

This MATLAB benchmark framework was developed to compare different methods for generating goal directed trajectories and extract their specificities, strengths and weaknesses. It allows each user to configure different perturbations which can occur during a movement execution and prepare their models for the given task before a baseline parameter set is used to create comparable results. For more information, please refer to the entry in CITEC's Cognitive Interaction Toolkit Catalogue (CITK): http://toolkit.cit-ec.uni-bielefeld.de/datasets/amarsi-benchmark-framework Software updates und support: https://opensource.cit-ec.de/projects/amarsi
VIDEO ANALYSIS OF ACUTE INJURIES DURING THE 24TH MEN'S HANDBALL WORLD CHAMPIONSHIP 2015 IN QATAR (2017)

Background Handball is a contact sport with a high prevalence of acute injuries. Injuries often occur during high-speed movements involving several players, making it difficult to describe the exact mechanism of injury. Objective Describe the mechanisms of injury in elite male handball. Design Prospective video analysis. Setting During the men´s handball world championship 2015, 132 injuries were reported through on-site injury surveillance by team medical staff. Based on the injury reports, two operators accessed the videos of each game and identified the specific injury situations using video analysis software (ProzoneHANDBALL v.1.0.0.14, ProzoneSports, Leeds, UK). Video analysis A total of 97 injury videos were identified; 42 were excluded, as the injury situation was not visible. Five handball experts performed an individual analysis of the 55 included videos based on a specific form developed to describe the injury situations and causes, followed by a consensus meeting. Main Outcome Measurements The form included variables related to the playing situation, landing situation, action of attacker and defender at time of injury and localization of tackle/hit. Results The most common injury location was the head and face (n=17, 31%), followed by the ankle (n=6, 11%). The most frequent injury cause was opponent contact (n=27, 49%), followed by landing trauma subsequent to opponent contact (n=8, 15%). The injuries were equally distributed between attackers (n=29, 53%) and defenders (n=26, 47%), but time-loss injuries (49%) were more common among attackers (68%). The most frequent playing action performed by injured attackers was a jump shot (n=9, 31%); tackles were most often to their throwing arm (n=7, 30%). Conclusions Acute injuries in elite male handball are equally distributed between attackers and defenders. However, attackers sustain more severe injuries. The most frequent injury causes are direct opponent contact and landing trauma after opponent contact.
Mobilization of Tn5 insertions from Rhizobium fredii by pJB3JI (1986)

Techniques for in vivo cloning were used with the fast-growing nitrogen-fixing soybean microsymbiont R. fredii USDA 191. Selection for transfer of Tn5 insertions from R. fredii USDA 191 containing the gene-mobilizing plasmid pJB3JI provided recombinants at up to 400 times the background mutation level. These techniques may be useful for future genetic analysis of R. fredii.
Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis (2017)

Our data suggest that Ld-RAC/AKT-like protein represents a Leishmania orthologue of mammalian AKT involved in parasite stress response and survival, and therefore could become a novel therapeutic and druggable target in leishmaniasis therapy. In addition, following comparative sequence analyses, we found the RAC/AKT-like proteins from Leishmania constitute a subgroup by themselves within a general AKT-like protein family.
Arsenite Regulates Cystic Fibrosis Transmembrane Conductance Regulator and P-glycoprotein: Evidence of Pathway Independence (2005)

In the past, people have argued for and against the theory of reciprocal regulation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and P-glycoprotein (Pgp). Data have indicated that this may occur in vitro during drug-induced selection of cells, and in vivo during development. Much of this debate has been caused by a severe lack of mechanistic details involved in such regulation. Our past data indicate that certain Pgp modulators can affect CFTR expression and function. The goal of this study was to investigate the effects of trivalent arsenic (arsenite), a known transcriptional activator of Pgp, on CFTR expression. In vitro analyses in T-84 cells that express basal levels of Pgp and CFTR were conducted using a variety of molecular techniques. Expressions of both genes were altered following treatment with arsenite in a dose- and time-dependent fashion. CFTR expression was suppressed almost three-fold by arsenite, along with a concomitant increase in P-glycoprotein expression. We also report that a member of the MAPK-family, the ERK-mediated signaling cascade is implicated in suppression of CFTR expression following treatment with arsenite. However, this particular pathway is not involved in regulation of P-glycoprotein expression in T-84 cells following treatment with arsenite. Thus, the regulatory pathways that control functional expression of CFTR and P-glycoprotein following arsenite treatment in T-84 cells are distinct and independent.
Large-Amplitude Transient Motion of Two-Dimensional Floating Bodies (1979)

A numerical method is presented for solving the transient two-dimensional flow induced by the motion of a floating body. The free-surface equations are linearized, but an exact body boundary condition permits large-amplitude motion of the body. The flow is divided into two parts: the wave field and the impulsive flow required to satisfy the instantaneous body boundary condition. The wave field is represented by a finite sum of harmonics. A nonuniform spacing of the harmonic components gives an efficient representation over specified time and space intervals. The body is represented by a source distribution over the portion of its surface under the static waterline. Two modes of body motion are discussed—a captive mode and a free mode. In the former case, the body motion is specified, and in the latter, it is calculated from the initial conditions and the inertial properties of the body. Two examples are given—water entry of a wedge in the captive mode and motion of a perturbed floating body in the free mode.
Energy Bucket: A Tool for Power Profiling and Debugging of Sensor Nodes (2009)

The ability to precisely measure and compare energy consumption and relate this to particular parts of programs is a recurring theme in sensor network research. This paper presents the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Energy</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Bucket</i> , a low-cost tool designed for quick empirical measurements of energy consumptions across 5 decades of current draw. The Energy Bucket provides a light-weight state API for the target system, which facilitates easy scorekeeping of energy consumption between different parts of a target program. We demonstrate how this tool can be used to discover programming errors and debug sensor network applications.Furthermore, we show how this tool, together with the target system API, offers a very detailed analysis of where energy is spent in an application, which proves to be very useful when comparing alternative implementations or validating theoretical energy consumption models.
Temperature compensation methods for junction‐isolated analog integrated circuits and their applications (1992)

Abstract This paper proposes temperature compensation methods used to improve circuit construction and to realize integrated circuits even at temperatures exceeding 200°C. The main purpose of a temperature compensation method is to maintain stability of dc bias in the high‐temperature range. The method is applied to the operational amplifier (OP‐AMP) to increase efficiency and to facilitate application to other circuits. A new OP‐AMP which can operate at high temperature is presented.
Photoresponsive Supramolecular Polymers (2018)

This chapter focuses on photoresponsive supramolecular polymers based on host-guest and metal-ligand complexation, complementary hydrogen-bonding interactions, and π-π stacking interactions between photochromic moieties. Supramolecular polymers based on π-π stacking interactions play important roles to discuss the underpinning principles. Huang and coworkers successfully prepared a photoresponsive metallosupramolecular polymer using a stiff stilbene functionalized with pyridine ligands. Intermolecular photoreactions such as photocyclization and photodimerization reactions observed for acenes can be applied to designing photoresponsive supramolecular polymers. The chapter highlights utilization of photochromic molecules to control the degree of supramolecular polymerization, the supramolecular polymerization process, and topologies of one-dimensional (1D) chains. It addresses specific design of supramolecular monomers inducing topological changes of 1D supramolecular chains, along with maintaining the degree of polymerization during photoisomerization. The chapter summarizes the application of photochromic molecules for other functional materials, such as vesicles, micelles, gels, organic nanotubes, biomolecular systems, and molecular machines.
Predictors of clinical response to immunotherapy with or without radiotherapy (2015)

Success with recent immunotherapies has resulted in previously unattainable response rates, as well as durable responses in diseases with historically poor prognoses. The combination of radiation therapy and immunotherapy has been a recent area of active investigation, with exciting results in a subset of patients. However, patient characteristics predictive of probable benefit from therapy and clinically meaningful biomarkers indicative of the early development of an antitumor immune response have yet to be identified. What is needed is a better way to predict which patients are likely to benefit from therapy, which would allow those patients unlikely to benefit from immunotherapy to be spared potentially futile therapies, thereby avoiding unnecessary risks of toxicity and costly treatment. Here, we summarize the early data on predictors of clinical response to immunotherapy, and to immunotherapy in combination with radiation.
Predicting Concrete Roadway Contribution to Gamma-Ray Background in Radiation Portal Monitor Systems (2014)

The collapse of the Soviet Union ushered in an era of interest in the security of the radiological and nuclear material holdings of the Russian Federation and other countries of the Former Soviet Union. Additionally, the increasing sophistication of international criminal and terrorist organizations highlighted the need to secure these materials and prevent them from being smuggled from their point of origin and across international boundaries. To combat the growing threat of radiological and nuclear smuggling, radiation portal monitors (RPMs) are deployed at ports of entry (POEs) around the world to passively detect gamma and neutron radiation signatures from cargo and pedestrian traffic. In some locations, RPMs are reporting abnormally high gamma-ray background count rates, a situation that has been attributed, in part, to the building materials surrounding the RPMs. The primary objective of this work was to determine the impact of different types of concrete on the gamma-ray background readings in a particular RPM. Secondary objectives include developing an adaptable model to estimate the gamma-ray background contribution from any composition of concrete in any RPM configuration and determining the elemental composition of different concrete samples through neutron activation analysis (NAA) techniques. The specific activities of 40K and isotopes from the 238U and 232Th decay series were determined with a high-purity germanium detector and computer-generated calibration files. Through NAA, 34 elemental compositions were determined for six concrete samples from three different parent slabs. The total weight percentages determined were 84% to 100% of the total mass of the samples. The Monte Carlo N-Particle (MCNP) transport code was used to simulate the RPM response to the different concrete slabs. The MCNP model was validated by comparing actual and simulated detector responses to 137Cs check sources of varying strengths. For all validation cases, the MCNP estimates were 6% to 16% less than the value obtained from the actual RPM data. This work shows that it is possible to estimate the gamma-ray response of an RPM to the underlying concrete roadway. Knowing the amount of this contribution will allow RPM customers to choose suitable foundation materials before installation and accurately set alarm thresholds. This could ultimately increase the ability of RPMs to detect radiation at POEs, thereby increasing the probability of a seizure of smuggled radiological and nuclear materials.
Objectives for Control and Provisioning of Wireless Access Points (CAPWAP) (2006)

This memo provides information for the Internet community. It does not specify an Internet standard of any kind. Distribution of this memo is unlimited. Copyright Notice Copyright (C) The Internet Society (2006). This document presents objectives for an interoperable protocol for the Control and Provisioning of Wireless Access Points (CAPWAP). The document aims to establish a set of focused requirements for the development and evaluation of a CAPWAP protocol. The objectives address architecture, operation, security, and network operator requirements that are necessary to enable interoperability among
Novel Bisabolanoids In Rosa Rugosa Leaves (1991)

Bisaborosaol A (1), a novel sesquiterpene belonging to the bisabolane class, was isolated from Rosa rugosa leaves. The absolute configuration of 1 at C-4 was shown to be inverted in comparison with bisabolanoids from Compositae. Bisaborosaol A (1) and its corresponding carboxylic acid (2) may be biogenetically related to the carotanoids which constitute the major sesquiterpenes of R. rugosa leaves
New lessons from an “old” drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia (2007)

Anthracyclines have been first line drugs for more than 3 decades in the treatment of acute myelogenous leukemia (AML). Even though the mechanism of action of anthracyclines has been extensively studied over the years, large gaps remain in our understanding of why they act better than most other drugs and how they induce cancer cell death. The present study was undertaken to identify protein changes that could shed further light on how the anthracyclines induce and execute apoptosis. By this approach, we hoped to identify proteins or pathways of particular importance in AML cell death that in the future could be exploited as new drug-targets and lead to the development and use of less toxic or more efficient drugs than the anthracyclines. We also expected to reveal weaknesses in anthracycline actions that could explain why many patients in the end develop resistance to the drug. Targeting these weak points by other drugs could open new avenues for combination treatment. By using various proteomic approaches to identify cleavage, degradation or altered phosphorylation of proteins, we found that components associated with the Hsp90 multi-protein complex, clathrin-mediated endocytosis, and protein synthesis to be targeted in cells undergoing or about to undergo anthracycline-induced apoptosis. The Hsp90 complex was targeted through cleavage of its co-chaperone p23. The truncation or downregulation of components of the clathrin-dependent endocytic pathway were associated with decreased endocytosis and increased accumulation of surface receptors with cell death-modulating capability. We also found that anthracyclines induced the pre-apoptotic synthesis of presumed anti-apoptotic proteins. That the pre-apoptotic protein synthesis served a net survival role was suggested by the ability of protein synthesis inhibitors to enhance anthracycline-induced cell death. This was true both in cell culture and in animal models of AML. In conclusion, the Thesis contributes to the knowledge of how anthracyclines induce apoptosis by pinpointing new protein targets and pathways that are heavily modified not only in the executionphase, but also in the induction-phase of apoptosis. Based on our findings, we propose a novel anthracycline-based combination treatment regime for patients with AML that consists of an anthracycline and a protein synthesis inhibitor administered in the pre-apoptotic phase.
Phased Retrofits in Existing Homes in Florida Phase II. Shallow Plus Retrofits (2016)

The BAPIRC team and Florida Power and Light (FPL) electric utility pursued a pilot phased energy-efficiency retrofit program in Florida by creating detailed data on the energy and economic performance of two levels of retrofit - simple and deep. For this Phased Deep Retrofit (PDR) project, a total of 56 homes spread across the utility partner's territory in east central Florida, southeast Florida, and southwest Florida were instrumented between August 2012 and January 2013, and received simple pass-through retrofit measures during the period of March 2013 - June 2013. Ten of these homes received a deeper package of retrofits during August 2013 - December 2013.