gebhart/patrepeval huggingface dataset:
Prostaglandins and the kidney (1977)

This review provides a summary and assessment of research involving renal prostaglandins. Arachidonic acid released from phospholipids is converted by prostaglandin cyclo-oxygenase in the kidney to PGF2, PGF2alpha, PGD2, and, possibly, to PGI2 and thromboxane A2. Production of PGE2 and PGF2alpha is predominately but not exclusively in the medulla, whereas degradative enzymes are present in both cortex and medulla. Prostaglandins enter the tubular lumen by facilitated transport and are partially reabsorbed from the urine in the distal nephron. Urine prostaglandins probably reflect renal synthesis. PGE2 and endoperoxides stimulate and PGF2alpha and indomethacin inhibit renal renin synthesis. In response to ischemia, vasoconstriction, or angiotensin II the kidney increases prostaglandin synthesis to modulate renal vascular resistance. In conscious animals or man no role has been established for prostaglandins in the maintenance of basal renal blood flow or renal sodium excretion. PGE influences renal water excretion by inhibiting the action vasopressin. Despite conflicting data there is evidence that renal prostaglandins are involved either primarily or secondarily in many types of hypertension. Inhibitors of prostaglandin cyclooxygenase have been used with success in Bartter's syndrome. Conflicting results in many areas of investigation may be resolved by the use of more accurate and reliable assays, careful handling of samples, and the use of urine to further investigate renal prostaglandin synthesis.
Two zebrafish mutants, <i>ebony</i> and <i>ivory</i>, uncover benefits of neighborhood on photoreceptor survival (2003)

Zebrafish offer a tractable system for the study of retinal development and degeneration, to provide insights into human retinal degeneration. We have begun to dissect the question of neighborhood effects on photoreceptor differentiation and survival through the isolation and characterization of mutants with retinal degeneration. We describe two mutants, ebony and ivory, isolated through a behavioral screen for blind mutants induced by ethyl nitrosourea mutagenesis. Chimeric analysis was conducted to attempt to rescue the photoreceptor degeneration. In ebony, the photoreceptor cell death was both cell autonomous and nonautonomous in nature, whilst the photoreceptor cell death was strikingly nonautonomous in ivory. The rescue at a distance is in keeping with a putative diffusible survival factor. We propose a density-dependent nonautonomous neighborhood effect to explain these findings.
An Update on Hydrogen Sulfide and Nitric Oxide Interactions in the Cardiovascular System (2018)

Hydrogen sulfide (H<sub>2</sub>S) and nitric oxide (NO) are now recognized as important regulators in the cardiovascular system, although they were historically considered as toxic gases. As gaseous transmitters, H<sub>2</sub>S and NO share a wide range of physical properties and physiological functions: they penetrate into the membrane freely; they are endogenously produced by special enzymes, they stimulate endothelial cell angiogenesis, they regulate vascular tone, they protect against heart injury, and they regulate target protein activity via posttranslational modification. Growing evidence has determined that these two gases are not independent regulators but have substantial overlapping pathophysiological functions and signaling transduction pathways. H<sub>2</sub>S and NO not only affect each other's biosynthesis but also produce novel species through chemical interaction. They play a regulatory role in the cardiovascular system involving similar signaling mechanisms or molecular targets. However, the natural precise mechanism of the interactions between H<sub>2</sub>S and NO remains unclear. In this review, we discuss the current understanding of individual and interactive regulatory functions of H<sub>2</sub>S and NO in biosynthesis, angiogenesis, vascular one, cardioprotection, and posttranslational modification, indicating the importance of their cross-talk in the cardiovascular system.
The rotator (1993)

SUMMARY The mean particle volume can be stereologically estimated using the nucleator principle. In the present paper, we discuss another principle for estimating mean particle volume, namely the rotator. The vertical rotator has already been previously described and is supplemented in the present paper by the isotropic rotator. For a collection of particle profiles, simulations show that the variance of the rotator is smaller than that of the nucleator.
Non‐immune VH‐binding Specificity of Human Protein Fv (1991)

The specificity of human F(ab)-binding Protein Fv (previously called Protein F), a sialoprotein released into the digestive tract mainly during hepatitis, was investigated with fragments or chains of monoclonal immunoglobulins. Protein Fv bound an unreduced H-chain dimer of a monoclonal human IgA2m(1) molecule but neither the corresponding L-chain dimer, nor several Bence-Jones molecules. Using enzymatic subfragments of F(ab)mu, or F(ab')2 gamma, a significant binding was observed with Fv fragments (VH + VL), while Fb fragments (CH1 + CL) were inactive. Taken altogether, these results prove that the structure recognized by Protein Fv is located in the VH domain. This structure probably involves discontinuous epitopes linked by a disulphide bond, which are destroyed by combined reduction and dissociation. Protein Fv does not interfere with the antigen-binding site, since there was no reciprocal inhibition with the antigen-antibody reaction.
体积小巧 本事不小——拍得丽DC-S5相机试用手记 (2003)

DC-S5（下文简称S5）是拍得丽最新推出的一款525万象素的数码相机，相机很小巧，而且质感很强。外壳是银灰色的塑料外壳，外形设计秉承了拍得丽一贯中规中矩的风格。不过，前面板吸取了日系相机在包装上的优点。一个彩色的主要参数说明贴纸给相机的整体印象增色不少。
Three-step pin assignment algorithm for building block layout (1992)

A new pin assignment algorithm is proposed which can be use in floorplanning and building block layout to minimise the total wiring length and channel area while satisfying the minimum distance constraint among pin positions on the block boundary. This algorithm can be used in floorplanning in which block shapes are iteratively modified by the channel density obtained as a result of global routing. The proposed pin assignment algorithm occurs in three steps: approximate pin assignment, global routing and detailed pin assignment. Experimental results were obtained using MCNC placement and floorplanning benchamark examples
Diversity of the Pyruvate Dehydrogenase Kinase Gene Family in Humans (1995)

Recent evidence from this laboratory indicates that at least two isoenzymic forms of pyruvate dehydrogenase kinase (PDK1 and PDK2) may be involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase complex by phosphorylation (Popov, K.M., Kedishvili, N.Y., Zhao, Y., Gudi, R., and Harris, R.A. (1994) J. Biol. Chem. 269, 29720-29724). The present study was undertaken to further explore the diversity of the pyruvate dehydrogenase kinase gene family. Here we report the deduced amino acid sequences of three isoenzymic forms of PDK found in humans. In terms of their primary structures, two isoenzymes identified in humans correspond to rat PDK1 and PDK2, whereas a third gene (PDK3) encodes for a new isoenzyme that shares 68% and 67% of amino acid identities with PDK1 and PDK2, respectively. PDK3 cDNA expressed in Eschierichia coli directs the synthesis of a polypeptide with a molecular mass of approximately 45,000 Da that possesses catalytic activity toward kinase-depleted pyruvate dehydrogenase. PDK3 appears to have the highest specific activity among the three isoenzymes tested as recombinant proteins. Tissue distribution of all three isoenzymes of human PDK was characterized by Northern blot analysis. The highest amount of PDK2 mRNA was found in heart and skeletal muscle, the lowest amount in placenta and lung. Brain, kidney, pancreas, and liver expressed an intermediate amount of PDK2 (brain > kidney = pancreas > liver). The tissue distribution of PDK1 mRNA differs markedly from PDK2. The message for PDK1 was expressed predominantly in heart with only modest levels of expression in other tissues (skeletal muscle > liver > pancreas > brain > placenta = lung > kidney). In contrast to PDk1 and PDK2, which are expressed in all tissues tested, the message for PDK3 was found almost exclusively in heart and skeletal muscle, indicating that PDK3 may serve specialized functions characteristic of muscle tissues. In all tissues tested thus far, the level of expression of PDK2 mRNA was essentially higher than that of PDK1 and PDK3, consistent with the idea that PDK2 is a major isoenzyme responsible for regulation of pyruvate dehydrogenase in human tissues.
Deconvolutional Feature Stacking for Weakly-Supervised Semantic Segmentation (2016)

A weakly-supervised semantic segmentation framework with a tied deconvolutional neural network is presented. Each deconvolution layer in the framework consists of unpooling and deconvolution operations. 'Unpooling' upsamples the input feature map based on unpooling switches defined by corresponding convolution layer's pooling operation. 'Deconvolution' convolves the input unpooled features by using convolutional weights tied with the corresponding convolution layer's convolution operation. The unpooling-deconvolution combination helps to eliminate less discriminative features in a feature extraction stage, since output features of the deconvolution layer are reconstructed from the most discriminative unpooled features instead of the raw one. This results in reduction of false positives in a pixel-level inference stage. All the feature maps restored from the entire deconvolution layers can constitute a rich discriminative feature set according to different abstraction levels. Those features are stacked to be selectively used for generating class-specific activation maps. Under the weak supervision (image-level labels), the proposed framework shows promising results on lesion segmentation in medical images (chest X-rays) and achieves state-of-the-art performance on the PASCAL VOC segmentation dataset in the same experimental condition.
A new multi-stage secret sharing scheme using one-way function (2005)

He and Dawson proposed a multi-stage secret sharing scheme based on one-way function. In that scheme, many secrets are reconstructed stage-by-stage in the dealer's predetermined order, and only one secret shadow is kept by every participant. When all the secrets have been reconstructed, the dealer needs not redistribute fresh shadows to every participant. Later, Harn further improved the He-Dawson scheme to reduce the total number of public values. However, in this paper, we will show that both the He-Dawson scheme and Harn's scheme are one-time-use schemes and that many secrets cannot in fact be reconstructed stage-by-stage. At the same time, we shall also modify the He-Dawson scheme to improve the drawbacks above and show the improved scheme can be applied.
StreamIt: A Compiler for Streaming Applications (2001)

Streaming programs represent an increasingly important and widespread class of applications that holds unprecedented opportunities for high-impact compiler technology. Unlike sequential programs with obscured dependence information and complex communication patterns, a stream program is naturally written as a set of concurrent filters with regular steady-state communication. The StreamIt language aims to provide a natural, high-level syntax that improves programmer productivity in the streaming domain. At the same time, the language imposes a hierarchical structure on the stream graph that enables novel representations and optimizations within the StreamIt compiler. We define the &quot;stream dependence function&quot;, a fundamental relationship between the input channels of two filters in a stream graph. We also describe a suite of stream optimizations, a denotational semantics for validating these optimizations, and a novel phased scheduling algorithm for stream graphs. In addition, we have implemented a prototype of the StreamIt optimizing compiler that is showing promising results.
Situation épidémiologique consécutive à la présence du parasite Bonamia Ostreae en Bretagne - Evolution au cours de l'année 1980 (1981)

Au mois de juin 1979, des mortalités anormales affectant l'huître plate, Ostrea edulis L., ont été constatées sur des parcs d'élevage de l'île Tudy en Bretagne, (Comps et coll., 1980). Les examens histologiques ont permis de déceler l'existence, dans les cellules sanguines des huîtres atteintes, d'un nouveau parasite, Bonamia ostreae gen., n., sp. n. (Pichot et coll., 1979). Depuis, l'extension de cette parasitose a été constatée par l'analyse mensuelle d'échantillons d'huîtres provenant de différents secteurs ostréicoles de Bretagne. La présente note donne des précisions sur la situation épidémiologique et sur son évolution au cours de l'année 1980 à la suite du développement de ce nouveau parasite.
Model checking the HAVi leader election protocol (1999)

The HAVi specification [9] proposes an architecture for audio/video interoperability in home networks. Part of the HAVi specification is a distributed leader election protocol. We have modelled this leader election protocol in Promela and Lotos and have checked several properties with the tools Spin and Xtl (from the Csar/Aldebaran package). It turns out that the protocol does not meet some safety properties and that there are situations in which the protocol may never converge to designate a leader. Our conclusion is that realistic timing requirements on sending and processing of messages should be added to the HAVi specification. Then a (timed) formal verification could give a definite answer with respect to correctness of the leader election protocol. 1991 Mathematics Subject Classification: 68M10, 68Q10, 68Q22, 68Q45, 68Q60, 68Q65 1991 ACM Computing Classification System: C.2.2, D.2.4, D.3.3, F.1.1, F.1.2, F.4.1, G.4 Keywords and Phrases: model checking, protocol verification, ab...
The effect of oil under in-situ conditions on the seismic properties of rocks (1992)

Abstract Direct hydrocarbon indicators (DHIs) on seismic sections are commonly thought to be diagnostic only of gas. However, oil sands can also generate DHIs such as bright spots and flat events since oils under in-situ conditions can contain large amounts of solution gas. This dissolved gas substantially decreases the velocity of sound and the density of the oils as compared to measurements of these properties at surface conditions. Hydrocarbon indicators caused by oil sands are investigated by first measuring the elastic properties of an oil as a function of gas-oil ratio, next, calculating the elastic properties of additional oil compositions under in-situ conditions using standard pressure-volume-temperature (PVT) measurements, and then calculating the compressional velocity in oil-saturated rocks for several typical oils using Gassmann's equation.The potential for seismic anomalies caused by oil-saturated rocks is higher than thought because the properties of oil under reservoir conditions can differ significantly from those of surface oils. Specif-ically:1) The properties of oil depend on its composition: the higher the API gravity and the gas-to-oil ratio (GOR), the lower the density and velocity of sound (adiabatic bulk modulus) and the lower the velocity of a rock saturated with the oil.2) Calculations of oil-sand velocities using the in-situ properties of oils show that areas having light oils and/or poorly consolidated rocks are the most likely areas in which to encounter oil DHIs. Since overpressured areas can have both poorly consolidated rocks and high GOR oils, they are especially prone to large oil responses.
Data Warehouse Design with UML (2005)

works for Sequence Processing, Automatic Translation: Foundation and Applications, Logic Programming, Information Extraction for Database Insertion, and Laboratory of Language Processing and Information Systems.From 2000 to 2001, I worked in my project for the PhD program and published my first papers in international conferences.Then, in the middle of 2001, I started to work in data warehouses until nowadays.I owe my appreciation to many great people for contributing to this work.First of all, I would like to thank my family for their incredible support, understanding, and patience.There are no words for their help.I would like to express words of gratitude for my advisor, Dr
Hospitality 2000 — The Technology: Building customer relationships (1999)

The strategic use of technology in marketing is one of the most significant challenges facing the hospitality industry. This paper reports on findings of a survey of global executives and addresses strategy, organisation, sales and marketing, customer information and operations as they relate to technology and its future role in the industry. It then focuses on the management of customer relationships using technology.
A query sampling method for estimating local cost parameters in a multidatabase system (2002)

In a multidatabase system (MDBS), some query optimization information related to local database systems may not be available at the global level because of local autonomy. To perform global query optimization, a method is required to derive the necessary local information. This paper presents a new method that employs a query sampling technique to estimate the cost parameters of an autonomous local database system. We introduce a classification for grouping local queries and suggest a cost estimation formula for the queries in each class. We present a procedure to draw a sample of queries from each class and use the observed costs of sample queries to determine the cost parameters by multiple regression. Experimental results indicate that the method is quite promising for estimating the cost of local queries in an MDBS.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Defining the Role of Trimetazidine in the Treatment of Cardiovascular Disorders: Some Insights on Its Role in Heart Failure and Peripheral Artery Disease (2014)

Trimetazidine is a cytoprotective drug whose cardiovascular effectiveness, especially in patients with stable ischemic heart disease, has been the source of much controversy in recent years; some have gone so far as to treat the medication as a 'placebo drug' whose new side effects, such as Parkinsonian symptoms, outweigh its benefits. This article is an attempt to present the recent key studies, including meta-analyses, on the use of trimetazidine in chronic heart failure, also in patients with diabetes mellitus and arrhythmia, as well as in peripheral artery disease. This paper also includes the most recent European Society of Cardiology guidelines, including those of 2013, on the use of trimetazidine in cardiovascular disease.
Protection Against UV‐Induced Reactive Intermediates in Human Cells and Mouse Skin by Glutathione Precursors: A Comparison of <i>N</i>‐Acetylcysteine and Glutathione Ethylester (1998)

Because glutathione (GSH) plays a central part in the endogenous defense against UV radiation, an increase in GSH might provide photoprotection. Two agents that increase GSH levels were investigated. Cultured human cells and mouse skin were treated with N-acetylcysteine (NAC) and glutathione ethylester (GSH-Et). After 30 min, the GSH level was determined by HPLC. Photoprotection was assessed by testing the ability of the thiols to scavenge UV-induced reactive intermediates in the same models. As compared to control cells, NAC and GSH-Et increased intracellular GSH in vitro to maximally 144% and 174% respectively. In vitro protection (maximum 23% for NAC and 21% for GSH-Et) did not correlate to the intracellular GSH level but to the concentration of the thiols in the medium. In vivo, epidermal GSH was increased to maximally 163% of the control level by NAC and 1234% by GSH-Et. The maximum in vivo photoprotection provided by GSH-Et was 55%, similar to what was found previously for NAC. Again, the protection seemed more closely correlated to the thiol dose than to the GSH level. The study showed that the protection against UV-induced reactive intermediates depends on a general antioxidant action of these thiols, rather than only on their role as GSH precursors.
Isolation and Characterization of Porcine Adipose Tissue-Derived Adult Stem Cells (2008)

Improved culture conditions and defined cellular characteristics of these porcine ADAS cells have been identified. Porcine ADAS can self-renew, can differentiate into multiple tissue lineages and they express CD34.
Fibrinolysis in Glomerulonephritis Treated With Ancrod: Renal Functional, Immunologic and Histopathologic Effects (1988)

The effects of a 14-day course of ancrod on fibrinolysis, renal function and structure, and immunologic findings are reported in 37 patients with glomerulonephritis. Patients were divided into two groups. In the first, the level of fibrin degradation products within 48 h was relatively low (less than 1 mg/ml). In these patients there was a linear relationship between changes in levels of fibrin degradation products and fibrinogen, suggesting that fibrin degradation products derived from ancrod-cleaved-fibrinogen in the circulating pool; in most, level of plasma alpha 2-antiplasmin before treatment was elevated. In the second, the level of fibrin degradation products within 48 h was high (greater than 1 mg/ml). Compared with the change in fibrinogen, a disproportionate increase in levels of fibrin degradation products suggested that a significant amount derived from sources other than plasmin digested ancrod-cleaved-fibrinogen, thus reflecting effective fibrinolysis, perhaps also in tissues; in most, the level of plasma alpha 2-antiplasmin was normal before treatment. In those with initial high levels of fibrin degradation products, higher levels persisted throughout treatment, changes in other fibrinolysis components were greater, and plasminogen activator inhibitor levels became normal. In patients with initial high but not with initial low response in fibrin degradation products renal function improved within 24 to 48 h and continued to improve thereafter; there was an immediate but temporary increase in proteinuria. Microvascular thrombosis decreased significantly, indicating effective removal of fibrin from glomeruli. The relation of early fibrinolysis to changes in immunologic and histopathologic findings was analyzed in patients with lupus nephritis. With ancrod, there was an increase toward normal of serum C3 and C4, a decrease in serum Igs, gamma globulin and anti-dsDNA antibody and in glomerular C3 and Ig deposits, suggesting that ancrod had favorable effects on immunologic factors. There were no clinical differences in patients with initial high and low responses, but the relationship of microvascular and inflammatory indexes before treatment differed. Initial renal biopsies and those after treatment were carried out on average 28 days apart. Inflammatory and microvascular indexes and glomerular thrombi decreased in patients with initial high levels of fibrin degradation products; fibrosclerosis index and glomerular sclerosis increased in patients with initial low levels of fibrin degradation products. Fibrinolysis expressed as the 48 h (fibrin degradation products/fibrinogen) ratio, correlated inversely with change in fibrosclerosis index and glomerular sclerosis in the whole group, and especially in those with initial high levels of fibrin degradation products.(ABSTRACT TRUNCATED AT 400 WORDS)