gebhart/patrepeval huggingface dataset:
Effect of pindolol on intraocular pressure. (1975)

Pindolol, a strong beta-adrenergic blocking agent, instilled into the conjunctival sac of normal and glaucomatous eyes, produced a significant drop in intraocular pressure. This was not, at first, accompanied by any variation in outflow facility; only after prolonged treatment did an increase in facility appear, which accounted only for one-third of the tension-lowering effect. The drug was well tolerated, and did not affect either pupil motility or corneal sensitivity. It seems suitable for a trial use in the treatment of glaucoma.
Development of a Pulse-Width Modulated Pneumatic Rotary Valve for Actuator Position Control (1993)

A new concept in the directional flow control of a high speed pneumatic actuation system is proposed. Two recent developments reported in the literature, namely (i) the application of pulse-width modulation techniques to on-off pneumatic valves and (ii) the introduction of a high speed rotary air valve, are merged in the design of a novel rotary flow control valve with built-in pulse-width modulation. Valve feasibility is demonstrated experimentally through the closed-loop position control of a pneumatic actuator. Static and dynamic performance characteristics as predicted by a detailed nonlinear lumped parameter model, compare favorably with measured data. Additionally, a simple linear time-invariant model, with a few empirical parameters, of the system is developed and validated through comparison with experiment and the nonlinear model. Then, several system design improvements based on this simple linear model are implemented and evaluated with the detailed nonlinear model.
Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs (2012)

In utero exposure to valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, causes neural tube, heart, and limb defects. Valpromide (VPD), the amide derivative of VPA, does not inhibit HDAC activity and is a weak teratogen in vivo. The detailed mechanism of action of VPA as a teratogen is not known. The goal of this study was to test the hypothesis that VPA disrupts regulation of the expression of genes that are critical in chondrogenesis and osteogenesis during limb development. Murine gestation day-12 embryonic forelimbs were excised and exposed to VPA or VPD in a limb bud culture system. VPA caused a significant concentration- dependent increase in limb abnormalities, which was correlated with its HDAC inhibitory effect. The signaling of both Sox9 and Runx2, key regulators of chondrogenesis, was downregulated by VPA. In contrast, VPD had little effect on limb morphology and no significant effect on HDAC activity or the expression of marker genes. Thus, VPA exposure dysregulated the expression of target genes directly involved in chondrogenesis and osteogenesis in the developing limb. Disturbances in these signaling pathways are likely to be a consequence of HDAC inhibition because VPD did not affect their expressions.
Planar Inverted-L Antenna With a Dielectric Resonator Feed in a Mobile Device (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A compact multiband planar inverted-L antenna (PILA) using a ceramic dielectric disk fed by a microstrip line in the mobile phone for GSM/DCS/PCS/UMTS operation is proposed. In this configuration, the PILA performs the functions of an effective radiator and the coupling feed structure of the ceramic dielectric disk is proposed to excite the PILA. By optimizing the proposed structure parameters, the structure resonates at two different bands to cover the desired multiband operation. In order to determine the performance of varying design parameters on bandwidth and resonance frequency, parametric study is carried out using simulation software HFSS and experimental results. The measured and simulated results show excellent agreement. </para>
Shear wave speed recovery in transient elastography and supersonic imaging using propagating fronts (2006)

Transient elastography and supersonic imaging are promising new techniques for characterizing the elasticity of soft tissues. Using this method, an 'ultrafast imaging' system (up to 10 000 frames s−1) follows in real time the propagation of a low frequency shear wave. The displacement of the propagating shear wave is measured as a function of time and space. The objective of this paper is to develop and test algorithms whose ultimate product is images of the shear wave speed of tissue mimicking phantoms. The data used in the algorithms are the front of the propagating shear wave. Here, we first develop techniques to find the arrival time surface given the displacement data from a transient elastography experiment. The arrival time surface satisfies the Eikonal equation. We then propose a family of methods, called distance methods, to solve the inverse Eikonal equation: given the arrival times of a propagating wave, find the wave speed. Lastly, we explain why simple inversion schemes for the inverse Eikonal equation lead to large outliers in the wave speed and numerically demonstrate that the new scheme presented here does not have any large outliers. We exhibit two recoveries using these methods: one is with synthetic data; the other is with laboratory data obtained by Mathias Fink's group (the Laboratoire Ondes et Acoustique, ESPCI, Université Paris VII).
How newsroom failures limit readership gains (1999)

The organisational structure and culture of newsrooms in Australia's newspapers militate against the effective application of readership recommendations. A lack of communication between and within departments, fear of the loss of editorial independence, and the absence of adequate review functions in leadership roles condemns newspapers to continuing failure to implement recommended content changes.
Effect of Drum Rotation Speed on Granular Flow: Comparison of DEM Simulation and PEPT Experiment (2000)

This paper describes an application of the discrete element method (DEM) to the simulation of granular flow in a horizontal drum. A drum with diameter of 100mm was 35% filled by mono-sized spheres of 3mm diameter. The drum rotated around its axis at a speed from 10 to 65 rpm. The dynamic angle of repose of the flow was calculated via least square fitting to the flow surface and was shown to increase with increasing drum rotation speed linearly. Velocity fields were obtained by volume-averaging the simulated results and comparison with the measurement by the so-called PEPT method indicated they are consistent with each other although velocity near free flow surface was larger in the DEM simulation. Dependence of flow behaviour on the rotation speed was also analysed in terms of radial and angular velocity distributions and ratio of flow velocity to drum speed.
Liquid chromatographic analysis of vitamin B6 in soy-based infant formula. (2002)

A liquid chromatographic (LC) method is described for determination of total vitamin B6 in soy-based infant formula. Total vitamin B6 is quantitated by using ion-pair LC after precolumn transformation of phosphorylated and free vitamers into pyridoxol. The limit of detection is 0.3 ng and the limit of quantitation is 1.0 ng on-column (injection volume = 100 microL). Linear response ranged from 39 to 616 ng/mL (r2 = 0.99986). Analysis of a soy-based infant formula control fortified at 6 different concentration levels gave recoveries that averaged 104%. Assay of SRM 1846 gave results within the certified range (8.6 +/- 0.086 mg/kg versus the certified value of 8.4 +/- 1.0 mg/kg). The method provides a rapid and specific assay for the analysis of total vitamin B6 in fortified soy-based infant formula.
3D structure reconstruction from an ego motion sequence using statistical estimation and detection theory (2002)

The paper discusses the problem of estimating 3D structures from an extended sequence of 2D images taken by a moving camera with known motion. The work is mainly concerned with sparse line features and thus is a natural extension of the feature-based motion analysis paradigm. Usually such a paradigm involves several separate operations: feature detection, feature matching, structure/motion estimation, and higher level processing, such as feature grouping. The authors propose to integrate the different phases based on the statistical estimation and detection theory. They show how each operation can be formalized and, in particular, consider the structure parameter estimation and the feature matching together as the combined estimation-decision problem. The proposed algorithm is tested with both synthetic and real data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Plasma renin activity and plasma prorenin assays (1991)

Sensitivity and accuracy are essential features of an assay of plasma renin activity (PRA) because the normal concentration of PRA is only 1 pmol/L, and subnormal concentrations have diagnostic relevance. Conditions for blood collection need to be standardized but the conditions are not difficult for outpatients. For routine diagnostic purposes blood should be collected from ambulatory (ideally, untreated) patients on moderate sodium intake. To avoid irreversible cryoactivation of plasma prorenin (which is present in 10-fold greater concentrations than renin), samples should be processed at room temperature and stored completely frozen. Cryoactivation occurs when plasma is liquid at temperatures less than 6 degrees C. PRA is commonly measured with an enzyme kinetic assay in which angiotensin I (Ang I) is formed by the reaction of plasma renin with endogenous renin substrate (angiotensinogen). The Ang I so formed is measured by RIA; results are expressed as an hourly rate (micrograms/L formed per hour). This method, which is provided by most commercial kits, has the potential for unlimited sensitivity because the step for Ang I generation can be prolonged as long as necessary, so that enough Ang I forms to be measured accurately. Unfortunately, that sensitivity is not always exploited. Dilution of plasma during pH adjustment should be kept to a minimum. The Ang I generation step should last at least 3 h. The step should last 18 h for samples with PRA less than 1.0 micrograms/L per hour, to eliminate the errors inherent in the measurement and subtraction of immunoreactive Ang I in the untreated plasma (blank subtraction). These changes actually simplify PRA measurements because they eliminate the need for ice in the clinic and reduce by almost half the number of samples to be assayed by RIA. I also describe the method for measurement of plasma prorenin, which may be an important marker for patients with diabetes mellitus who subsequently develop vascular complications.
Reaction of Soybean Cultivars to Sclerotinia Stem Rot in Field, Greenhouse, and Laboratory Evaluations (2000)

Sclerotinia stem rot of soybean [ Glycine max (L.) Merr.], caused by the fungal pathogen Sclerotinia sclerotiorum (Lib.) de Bary, recently has increased in importance in the northern U.S. soybean production area. The objective of our study was to determine the effectiveness of three different inoculation techniques in predicting the field reactions of cultivars to sclerotinia stem rot. Eighteen soybean cultivars were field tested in six Michigan environments from 1994 to 1996 and tested in the greenhouse or laboratory with three inoculation methods. The cultivars were inoculated by placing infested oat ( Avena sativa L.) seed or mycelial plugs on cotyledons or by placing mycelial plugs on detached leaves. There were significant ( P < 0.05) differences in resistance to sclerotinia stem rot among cultivars at all but one field environment and for all inoculation methods. The disease severity ratings based on the inoculations were significantly correlated with the field results, with the exception of one method. Disease severity ratings for the three inoculation methods were significantly correlated with only two exceptions. Cultivars such as Novartis S19‐90 and Corsoy 79 consistently had the lowest disease severity ratings in the field tests and for the inoculation methods. Similarly, a number of cultivars were rated as susceptible in all tests. Ratings for cultivars with intermediate reactions were not consistent across tests. The inoculation methods tested can provide some useful information on the resistance of soybean genotypes to sclerotinia stem rot. However, resistance identified by inoculation methods should be confirmed with field tests, since these methods can misclassify the resistance of some cultivars.
Evaluating the Perceived Value of a First-Year Engineering Experience (2024)

is the director of
A big-picture look at enterprise architectures (1999)

It makes sense to plan the growth of your information systems. But many attempts to create a road map start at the wrong level. Ensuring a consistent, coherent vision to direct the evolution of the enterprise's information systems is difficult enough with a development framework. Without one, it's impossible. The concepts we outline are just a task list in the work to establish an enterprise architecture, but they give you some idea of the breadth of the job ahead of you. However, we hope we've given you a start toward a more realistic vision of your enterprise architecture.
Development of a Toxic Bait for Control of Mole Crickets (Orthoptera: Gryllotalpidae) (1987)

Journal Article Development of a Toxic Bait for Control of Mole Crickets (Orthoptera: Gryllotalpidae) Get access R. L. Kepner, R. L. Kepner Department of Entomology and Nematology, University of Florida, Gainesville, Florida 32611 Search for other works by this author on: Oxford Academic PubMed Google Scholar S. J. Yu S. J. Yu Department of Entomology and Nematology, University of Florida, Gainesville, Florida 32611 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 80, Issue 3, 1 June 1987, Pages 659–665, https://doi.org/10.1093/jee/80.3.659 Published: 01 June 1987 Article history Received: 04 March 1986 Published: 01 June 1987 Accepted: 31 December 1987
Therapy of acute hepatitis C (2002)

Acute hepatitis C has a high propensity to become chronic, which provides the rationale for treating patients with acute disease attempting to prevent chronicity. Almost all published studies on therapy of acute hepatitis C have been small in size, uncontrolled, and highly heterogeneous as to patient features, dose and duration of treatment, follow-up evaluation, and criteria used to define efficacy and safety. The published studies on treatment of acute hepatitis C have used standard alfa or beta interferon monotherapy: none have evaluated combination therapy of interferon and ribavirin or peginterferon. Several meta-analyses of published studies have concluded that initiation of interferon monotherapy during the acute phase of hepatitis C virus (HCV) infection significantly reduces (by 30% to 40%) evolution to chronic hepatitis. The tolerability of interferon in acute hepatitis C has been excellent, even in symptomatic and icteric patients; the side effects and adverse events being similar in type and frequency to those seen when treating chronic cases. Thus, currently available data support treatment of patients with acute hepatitis C, but data are insufficient to draw firm conclusions about which patients to treat, when therapy should be started, or what regimen is optimal. Future studies of adequate size and design should focus on efficacy and tolerability of peginterferons and whether therapy should be started immediately after diagnosis or delayed for 2 to 4 months to avoid treatment of patients who spontaneously recover.
Self-mixing interferometer based on sinusoidal phase modulating technique (2005)

A new self-mixing interferometry based on sinusoidal phase modulating technique is presented. Self-mixing interference occurs in the laser cavity by reflecting the light from a mirror-like target in front of the laser. Sinusoidal phase modulation of the beam is obtained by an electro-optic modulator (EOM) in the external cavity. The phase of the interference signal is calculated by Fourier analysis method. The interferometer is applied to measure the displacement of a high-precision commercial PZT with an accuracy of <10nm. The measurement range of the system mainly depends on the maximum operating frequency of EOM and the maximum sampling rate of A/D converter.
Could this be you (1965)

I am going to try to put before you some aspects of yourselves as seen by someone completely distant from your profession.
Coverage problems in sensor networks (2011)

Sensor networks, which consist of sensor nodes each capable of sensing environment and transmitting data, have lots of applications in battlefield surveillance, environmental monitoring, industrial diagnostics, etc. Coverage which is one of the most important performance metrics for sensor networks reflects how well a sensor field is monitored. Individual sensor coverage models are dependent on the sensing functions of different types of sensors, while network-wide sensing coverage is a collective performance measure for geographically distributed sensor nodes. This article surveys research progress made to address various coverage problems in sensor networks. We first provide discussions on sensor coverage models and design issues. The coverage problems in sensor networks can be classified into three categories according to the subject to be covered. We state the basic coverage problems in each category, and review representative solution approaches in the literature. We also provide comments and discussions on some extensions and variants of these basic coverage problems.
Perfect and imperfect particles (1986)

The theory of magnetization reversal process in an isolated, ellipsoidal particle is rigorous, and its results are unambiguous. There is no approximation in this theory, except for the assumption of a perfect single crystal, with a perfectly smooth spheroidal surface, and nothing new can be found, as long as this assumption is maintained. In order to advance towards a theory of realistic particles, one must look for ways to take into account the effect of nonellipsoidal shape and of crystalline defects, as well as the effect of magnetic interactions between the particles.
Tubular Nerve Guide and Epineurial Repair: Comparison of Techniques for Neurorrhaphy (1994)

Experiments were conducted on 36 male, Sprague-Dawley rats. In 10 animals, neurorrhaphy was performed on the peroneal nerve with epineurial repair and, in 11 animals, with a tubular polyethylene nerve guide. The authors tested the hypothesis that, following transient denervation of a skeletal muscle by transection of a peroneal nerve, the restoration of maximum force and of maximum specific force developed after insertion of a tubular nerve guide, will not be different from that developed after microsurgical epineurial neurorrhaphy. The contractile properties of the extensor digitorum longus (EDL) muscle, innervated by the peroneal nerve, were evaluated after an average of 116 days. The maximum tetanic force of EDL muscles with epineurial repair and nerve guide were 84 percent and 75 percent, respectively, of the value for control EDL muscles. The specific forces of the muscles in both groups were not different from the control values. The conclusion is that, following stabilization after transection and repair, each of the two methods was equally effective in restoring the ability of the muscle to develop force.
Study on the Low Temperature PC, PN, PC and PN Combined Treatments of AISI 316 Austenitic Stainless Steel (2004)

Surface hardening of AISI 316 austenitic stainless steel without degradation of corrosion resistance was carried out using plasma carburising,plasma nitriding and their combination processes at low temperature. It was found that the supersaturation of the N or/and C in the austenitic lattice and the precipitation-free layer on austenitic stainless steel (i.e. the S phase) could enhance the layer hardness and wear resistance. The compound layer after the duplex treatments of PC and PN not only have a high hardness as that of plasma nitriding, but also have a hardness gradient profile as that of plasma carburising.
Randomized feasibility study of suction‐tube uterine tamponade for postpartum hemorrhage (2019)

Registered in the Pan African Clinical Trial Registry as PACTR201809584199573.
Bandwidth enhancement through coupling microstrip patch antenna and electromagnetic band-gap resonances (2012)

A combination of patch antenna and electromagnetic band-gap structure, for bandwidth enhancement purposes, is presented. To overcome several intrinsic limitations of patch antennas such as narrow bandwidth, low gain, excitation of surface waves, the EBG concept is used. The patch antenna and patch antenna surrounded by the EBG cells are characterized in terms of return loss and radiation pattern in an anechoic chamber.
Uptake of 5-Iododeoxyuridine as a Measure of Tumor Growth and Tumor Inhibition (1975)

The DNA synthesis of tumor cells in spleen, lung and liver of mice bearing spontaneous or transplanted lymphomas or Lewis lung carcinoma was determined by measuring the uptake of 5-iododeoxyuridine labeled with iodine-125 (125IUdR). An in vitro uptake method was also developed to assess 125IUdR uptake of peripheral blood of leukemic animals. A direct relationship was found between isotope uptake values and the extent of neoplastic growth. The 125IUdR uptake method was found to be applicable to determination of inhibition of tumor growth in drug-treated animals and in pre-sensitized allogeneic hosts and to measurement of regression in non-sensitized allogeneic mice.
Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition (2015)

Succinate dehydrogenase inhibition with malonate at the onset of reperfusion reduces infarct size in isolated mice hearts through reduction in ROS production and mitochondrial permeability transition pore opening.
N-terminal α-amino group modification of peptides by an oxime formation–exchange reaction sequence (2013)

A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed.
R&R Matrix 도입을 통한 건설현장 업무분장 방식 개선 방법 (2015)

건설현장의 업무효율을 향상시키기 위한 시도는 다양한 방면에서 존재해 왔다 그러나 업무분장방식 개선을 통하여업무효율을 증진시키려는 시도는 부족했고 따라서 기존의 업무분장 방식에 대한 조사와 개선방안에 대한 연구 역시 부족하다 이에 따라 본 논문에서는 기존업무분장 방식의 업무분장의 불명확성 업무상 정보공유에 관한 체계 부재 의측면에 주목하여 문제점을 분석하고 현장 실무자들을 대상으로 설문조사 및 면담조사를 실시하여 현 업무분장방식에대한 인식을 조사 하였다 그리고 이에 대한 개선 방안으로 타 산업에서 명확한 업무분장을 위해 사용되고 있는를 제시하고 이를 건설공사 중 가장 큰 비중을 차지하고 있는 골조공사의 업무분장에 적용하여 기존 업무분장방식의 개선 가능성을 연구해보고자 한다.
Experiences in developing multi-technology TMN systems (2002)

Integration of management systems across technological and administrative domain boundaries is a necessary prerequisite for automating or optimising service management. Despite many years of standardisation effort the number of management technologies and interface specifications seems to continue to increase. An architectural approach to integrated network management, therefore, cannot be based on any single architecture or technology, but must instead be based on recognition of diversity and interoperability. The TMN-architecture is basically such an integration architecture, although OSI is sometimes assumed to be the only realisation option. This paper presents experiences with the approach taken to realise integrated network management in the European ACTS project Prospect (project number AC052). Several layers of integration have been realised, including multi-vendor and inter-domain management, and several management technologies have been integrated, namely CORBA, OSI and SNMP.