gebhart/patrepeval huggingface dataset:
A successful second renal allograft across positive B‐cell crossmatch due to IgG anti‐HLA DR5 antibody (1992)

The role of antibodies specific to donor B‐cell antigens in renal transplantation remains to be firmly established. We have used, in a sensitized patient awaiting his second transplant, reduction with dithiothreitol (DTT), platelet absortion and panel reactivity analysis to identify imunoglobulin class and specificity of the antibody causing positive B‐cell crossmatch. The results show that the antibody was an IgG anti‐HLA DR5. The transplant was performed using the recipient's mother, specifically mismatched for DR5, as donor. The graft has excellent function 18 months after transplantation. The experience with this patient raises questions about the clinical significance of anti‐DR antibodies, and of anti‐B cells antibodies in general, in kidney transplantation.
Stress relaxations at low frequencies in fluid‐saturated rocks: Attenuation and modulus dispersion (1981)

A new laboratory apparatus measures the complex Young's modulus of rock samples at frequencies between 4 and 400 Hz and at strain amplitudes near 10 −7 . There is negligible attenuation and modulus dispersion in vacuum‐dry rocks. In water‐saturated samples of sandstone, limestone, and granite there are large attenuation peaks which are caused by stress relaxations. The attenuation and modulus data can be described by Cole‐Cole distributions of relaxation times. The rock anelasticity therefore satisfies the Kramers‐Kronig integral relations. The stress relaxations occur at low frequencies, have narrow distributions of characteristic times, are thermally activated, and have activation energies (16–22 kJ/mol) which are characteristic of hydrogen bonds. The modulus defect and peak attenuation are shown to vary with different pore fluids (water, ethanol, and n ‐decane). The results are explained in terms of the pore fluids lowering the surface free energy of the rock‐forming minerals. The relaxation process involves the movement of fluid molecules. The molecules, by bonding to the surface, reduce the surface energy and thus generate the frequency‐dependent softening in the rock.
Consideraciones metodológicas para la impartición de la asignatura de Seguridad Nacional en la Universidad de Ciencias Pedagógicas (2017)

Se fundamentan algunas concepciones metodológicas sobre la seguridad nacional en el futuro docente y en ejercicio, que promuevan un modo de actuación profesional acorde con la sociedad socialista actual, como principales auxiliares de la política del Estado para la formación de las nuevas generaciones. Se sistematiza el papel de Seguridad Nacional que sirve de base para que la enseñanza sea multilateral, armónica y con enfoque dialéctico materialista.
A token ring local area network (LAN) for campus wide communication based on the TI TMS380 adapter chipset (2002)

The commonest LAN is Ethernet, which uses a bus topology in which the network user stations connect to a common linear cable by network interface units. Common problems with this network are the bus contention problem and the need for expensive repeaters to boost signal strength. The concept of the token ring LAN is introduced to solve these problems. This project was divided into two parts. The first part is the design and development of the complete 68000-based computer system with timing calculations. The second part includes the interfacing of this computer system to a TI TMS380 LAN adapter chipset. These two phases are discussed. The authors present the design of the complete system and its installation in the University of New Orleans Computer Application Laboratory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Two-dimensional color Schlieren system (1990)

In this two-dimensional color Schlieren system, the typical square or circular Schlieren filters are replaced by a T-shaped filter. Such a filter lets more light pass through and is more sensitive, thus creating a better Schlieren system.
Efficient Control Channel Resource Allocation for VoIP in OFDMA-Based Packet Radio Networks (2011)

We propose an efficient control channel resource allocation approach to enhance the performance of voice-over-IP (VoIP) in orthogonal frequency division multiple access- (OFDMA-) based next generation mobile communication systems. As the long-term evolution (LTE) of universal terrestrial radio access network (UTRAN), evolved UTRAN (E-UTRAN) is the first OFDMA-based packet radio network and thus selected in this paper as an application example. Our proposed physical downlink control channel (PDCCH) resource allocation approach for E-UTRAN is composed of bidirectional power control, inner loop link adaptation (ILLA), and outer loop link adaptation (OLLA) algorithms. Its effectiveness is validated through large-scale radio system level simulations, and simulation results confirm that VoIP capacity with dynamic scheduling can be further enhanced with this PDCCH resource allocation approach. Moreover, the VoIP performance requirements for international mobile telecommunications-advanced (IMT-Advanced) radio interface technologies can be met with dynamic scheduling together with proposed PDCCH resource allocation. Besides E-UTRAN, this approach can be introduced to other OFDMA-based mobile communication systems for VoIP performance enhancement as well.
Cryotherapy in the treatment of nasal obstruction: indications in adults (1995)

Cryotherapy is an established method of treating hypertrophic obstructive inferior turbinates. The long-term effectiveness of the technique is assessed in this study, using the need for alternative nasal surgery as an objective way of distinguishing success from failure. Over 50 per cent of patients with obstructive symptoms, including those with minor septal deviation or allergy derived lasting benefit from the technique. Cryotherapy is an effective means of treating nasal obstruction due to mucosal hypertrophy of the turbinates and may replace the need for more radical surgery.
Dissection of antibody-antigen interactions for development of antibodies (2013)

抗体はその高い抗原特異性、親和性から、治療薬、診断薬に用いられており、各分野で抗体開発が盛んに行われている。抗体配列遺伝子が手に入れば、我々は、その抗体が持つ機能を認識素子として利用し、さまざまな改変抗体を構築することができるようになっている。しかしながら、抗体がどのように抗原に対して高い特異性・親和性を創出するかについて、構造的に、またエネルギー的に理解されるようになったのはごく最近のことである。本稿では、抗原抗体相互作用を生物物理学的にどのように性格づけするかについて、まず、代表的な解析方法についてまとめ、つづいて抗体が標的分子をどのように認識し、高親和性を創出しているかについて述べる。
An approach to the specification of user interface templates for business applications (2012)

Through a number of research projects we propose a form-driven approach to business application generation. Our IIS*Studio development environment (IIS*Studio DE, current version 7.1) is aimed to support the form-driven approach and provides the information system (IS) design and generating executable business application prototypes. An executable business application specification, generated by means of IIS*Studio, may be visually interpreted in different ways. In the paper we present the extension of the IIS*Studio repository containing the common model of user interface (UI). The IIS*UIModeler is an integrated part of the IIS*Studio development environment, aimed at modelling UI templates. Applying it, a designer specifies UI templates. UI template specification contains attribute values that describe common UI characteristics, such as: screen size, main application window position, background/foreground colour, etc. UI template specifications are independent from any specific IS project specification, generated by means of IIS*Studio tool. The same UI template may be used for the business application prototype generation of different ISs. Also, the same IS project specification may be visually interpreted in different ways by means of different UI templates. The specification of a UI template may be seen as a fully platform independent UI model. Besides the detail description of UI template common model, we illustrate the main features of the IIS* UIModeler tool.
P‐4: Integrated a‐Si TFT Gate Driver with Reducing Clock Duty Ratio (2009)

Abstract A 15 inch wide type LCD using an integrated a‐Si TFT gate driver has been developed. The gate driver driven by the clocks with the duty ratio of lower than 50% can use only one large output TFT to charge and discharge the gate line so that the pull‐down TFT in the gate driver can be eliminated and the required layout area for the gate driver can be also reduced.
Authentication for distributed systems (1992)

A number of protocols used to authenticate users, hosts and processes are described. The three main types of authentication in a distributed computing system-message content authentication, message origin authentication, and general identity authentication-are explained. Authentication exchanges are identified, and paradigms of authentication protocols are presented. Authentication protocol failures are addressed, and an authentication framework is provided. As case studies, two authentication services, Kerberos and SPX, are examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rapid and Highly Sensitive Extended Gate FET-Based Sensors for Arsenite Detection Using a Handheld Device (2020)

Heavy metals are very harmful to the environment and is toxic which affects the human health. Monitoring the heavy metal ion in food and water is necessary. In this research, we developed a FET based ion selective sensor for detecting Arsenite (As(III)) ions by a hand held device. The sensor characteristics are carried out and illustrated. This selective sensor shows higher sensitivity (35.19 mV/log [As 3+ ]) than the ideal Nernstian slope. The dynamic range of the Arsenite based ion sensor is from 10 −10 M to 10 −4 M. The detection limit of this FET based ion selective sensor is below 10 −10 M and is comparable to ICP-MS. The sensor captures the particular target ion and is not affected by the interfering ions such as Cadmium and Lead. The sensitivity and selectivity characteristics are comparatively better than the traditional potentiometric Ion selective electrode (ISE). The sensor has shorter response time and is easy to operate. This sensor is affordable for everyone and convenient to use for monitoring the food and drinking water frequently.
Efficacy and safety of a new combination of calcipotriol and betamethasone dipropionate (once or twice daily) compared to calcipotriol (twice daily) in the treatment of psoriasis vulgaris: a randomized, double-blind, vehicle-controlled clinical trial (2002)

No statistically significant nor clinically relevant difference in efficacy was seen between the combined formulation used once daily and twice daily. When compared to vehicle ointment or calcipotriol ointment alone, the combined formulation was shown to be clearly more efficacious.
Quinazoline pharmacophore in therapeutic medicine (2016)

<p>This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic targets. It traverses numerous biological potentials of quinazoline in the contemporary time to allow researchers’ unhindered access to the beneficial role of quinazoline in fighting infectious diseases for future drug discovery. This work provides broad overview of medicinal survey of quinazoline chemistry valuable in the discovery of more efficient clinical trials and to summarize the most promising molecular targets for drug design. </p>
Emergency surgery complicated by thyrotoxicosis and thyrotoxic periodic paralysis (1985)

A general anaesthetic was administered for emergency surgery to a patient with a bleeding gastric ulcer in the presence of undiagnosed thyrotoxicosis. The case is presented to illustrate firstly how hyperthyroidism may be masked by other acute illnesses, and secondly an unusual complication of thyrotoxicosis. The anaesthetic management of thyrotoxic patients undergoing incidental emergency surgery is discussed.
A fluorescence in situ hybridization technique for retrospective cytogenetic analysis (1991)

Fluorescence in situ hybridization (FISH) is being used increasingly in clinical practice; however, current FISH techniques require fresh material, and there is considerable variation in hybridization efficiency between laboratories. We have modified a FISH technique described by Pinkel et al. (1986) that works not only on freshly G-banded material but also on cytogenetic preparations ranging in age from 2 wk to 12 yr. We have tested this technique on several centromeric alphoid satellite probes (D1Z5, D7Z1, D17Z1, DXZ1, and DYZ3) and one noncentromeric minisatellite probe (D1Z2). Our average hybridization efficiency on freshly banded preparations for these probes is consistently greater than 90%. The combination of higher efficiency and the ability to perform hybridization on previously G-banded material makes this a valuable technique for retrospective analyses.
Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam study (2005)

Cerebral blood flow (CBF) velocity is decreased in patients with Alzheimer's disease. It is being debated whether this reflects diminished demand because of advanced neurodegeneration or that cerebral hypoperfusion contributes to dementia. We examined the relation of CBF velocity as measured with transcranial Doppler with dementia and markers of incipient dementia (ie, cognitive decline and hippocampal and amygdalar atrophy on magnetic resonance imaging) in 1,730 participants of the Rotterdam Study aged 55 years and older. Cognitive decline in the 6.5 years preceding CBF velocity measurement was assessed with repeated Mini-Mental State Examinations in nondemented subjects (n = 1,716). Hippocampal and amygdalar volumes were assessed in a subset of 170 nondemented subjects. Subjects with greater CBF velocity were less likely to have dementia. Furthermore, in nondemented subjects, greater CBF velocity was related to significantly less cognitive decline over the preceding period (odds ratio per standard deviation increase in mean CBF 0.74 [95% confidence interval, 0.58-0.98]) and larger hippocampal and amygdalar volumes. A low CBF is associated with dementia, but also with markers of incipient dementia. Although we cannot exclude that this is caused by preclinical neurodegeneration leading to hypoperfusion, it does suggest that cerebral hypoperfusion precedes and possibly contributes to onset of clinical dementia.
Adherence to single daily dose of aspirin in a chemoprevention trial. An evaluation of self-report and microelectronic monitoring (1996)

A consecutive sample of 64 healthy adults (33 female and 31 male) were recruited at the University of Michigan Medical Center, Ann Arbor. Data were available for analysis on 57 subjects. The participants were asked to take a single daily dose of aspirin ranging from 0 to 640 mg. Adherence to the daily aspirin ingestion was measured by self-report and the Medication Event Monitoring System (MEMS, Aprex Corp, Fremont, Calif); adherence rate for the study population was 35%. The adherence rates for all dosing errors between self-report and Medication Event Monitoring System were significantly different (P = .002). There was no significant gender difference in adherence rates. Adherence to regular aspirin ingestion was poor in healthy, paid subjects despite explicit, written and verbal instructions. Patient self-report alone is not a reliable measure of adherence.
[A brief introduction to the methods for novel gene cloning]. (2000)

There are a lot of methods for novel gene cloning, but how to clone candidate gene(s) quickly and correctly? This is a brief introduction to methods of novel gene cloning, these methods includes: differential display reverse transcriptase polymerase chain reaction(DD RT-PCR), suppression subtractive hybridization(SSH), RNA arbitrarily primed PCR(RAP-PCR), representational difference analysis(RDA), yeast two-hybrid system, cDNA capturation, et al. We not only introduced these methods, but also discussed the advantages and disadvantages of them. However, no single method is omnipotent, one should pick up the method most suitable for a special purpose.
Cation transport and volume regulation in sickle red blood cells (1993)

Cellular dehydration is one of several pathological features of the sickle cell. Cation depletion is quite severe in certain populations of sickle cells and contributes to the rheological dysfunction that is the root cause of vascular occlusion in this disease. The mechanism of dehydration of sickle cells in vivo has not been ascertained, but three transport pathways may play important roles in this process. These include the deoxygenation-induced pathway that permits passive K+ loss and entry of Na+ and Ca2+; the K(+)-Cl- cotransport pathway, activated by acidification or cell swelling; and the Ca(2+)-activated K+ channel, or Gardos pathway, presumably activated by deoxygenation-induced Ca2+ influx. Recent evidence suggests that these pathways may interact in vivo. Heterogeneity exists among sickle cells as to the rate at which they become dense, suggesting that other factors may affect the activity or interactions of these pathways. Understanding the mechanism of dehydration of sickle cells may provide opportunities for pharmacological manipulation of cell volume to mitigate some of the symptoms of sickle cell disease.
Evaluation of Toxic Metals in Blood and Urine Samples of Chronic Renal Failure Patients, before and after Dialysis (2008)

The determination of toxic elements in the biological samples of human beings is an important clinical screening procedure. The aim of this work was to determine total content of toxic elements-aluminum (Al), cadmium (Cd), and lead (Pb)-in whole blood and urine samples of male chronic renal failure patients (CRFPs) on maintenance hemodialysis from 2006 to 2007. The study included 100 CRFPs, plus 150 healthy volunteers in the control group. The concentration of toxic elements (TEs) were determined in blood sample before and after hemodialysis, while urine sample was determined once, before dialysis. Toxic elements were analyzed by electrothermal atomic absorption spectrometer, prior to microwave-induced acid digestion. The accuracy of the total Al, Cd, and Pb measurements was tested by simultaneously analyzing certified reference materials. No significant differences were established between the analytical results and the certified values (paired t-test at p > 0.05). The levels of TEs in blood samples of patients before dialysis were found to be higher than blood samples after dialysis session. In the control group, the blood levels of Al, Cd, and Pb were significantly lower than the chronic renal failure patients. Moreover, the study shows that analyzing levels of Al, Cd, and Pb may be useful in hemodialysis patients in evaluating TEs status.
Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (1990)

A mixed-oligonucleotide probe was used to identify four ras-like coding sequences in a human teratocarcinoma cDNA library. Two of these sequences resembled the rho genes, one was closely related to H-, K-, and N-ras, and one shared only the four sequence domains that define the ras gene superfamily. Homologs of the four genes were found in genomic DNA from a variety of mammals and from chicken. The genes were transcriptionally active in a range of human cell types.
Studies on the effect of feeding cupric sulfate pentahydrate to laying hens on egg cholesterol content (1998)

Two experiments were conducted to test the hypothesis that pharmacological levels of dietary Cu could reduce egg cholesterol content. White Leghorn hens 30 to 39 wk of age were fed corn and soybean meal diets with 0, 125, or 250 mg supplemental Cu/kg diet from cupric sulfate pentahydrate (basal diet = 6.74 mg Cu/kg). Body weight, feed consumption, egg weights, egg specific gravity, and Haugh Units were not consistently affected during the 8-wk feeding trials. Egg production was significantly increased (P < 0.05) in the second 4-wk period by supplemental Cu in both experiments. Egg yolk cholesterol concentrations were decreased by feeding 125 mg Cu/kg diet (11.7 vs 8.6 mg/g, average of two experiments); feeding 250 mg Cu/kg resulted in further declines in egg cholesterol but the differences were not significant (7.9 mg/g). Changes in plasma cholesterol concentrations were similar to those of yolk cholesterol. Small but significant amounts of Cu accumulated in the yolks and shells of eggs from Cu-supplemented hens; however, most of the Cu fed was found in the excreta.
Development of a Broad Range Turbocharger using Compressor-to-Turbine Bleed (1982)

<div class="htmlview paragraph">A turbocharger, incorporating bleed flow from the compressor to the turbine, was developed towards the objective of improving the lug performance of the Army's VHO diesel engine, without the complexity of variable geometry diffuser vanes.</div> <div class="htmlview paragraph">An existing VHO engine turbocharger was redesigned and modified for bleed flow testing. The bench and engine test results indicated that the configuration bleeding from both the diffuser hub and the diffuser vane suction surface gave over 75% improvement in baseline engine lug torque. In addition, the bleed flow turbocharger gave improved engine BSFC, with a measured value of less than .39 lb/bhp hr. The lug torque improvements were obtained while maintaining rated engine power.</div> <div class="htmlview paragraph">The results of this program indicate that the bleed flow turbocharger can give significant improvements in lug engine performance without the complexity of variable geometry diffuser vanes.</div>
Audiometry screening and interpretation. (2013)

The prevalence of hearing loss varies with age, affecting at least 25 percent of patients older than 50 years and more than 50 percent of those older than 80 years. Adolescents and young adults represent groups in which the prevalence of hearing loss is increasing and may therefore benefit from screening. If offered, screening can be performed periodically by asking the patient or family if there are perceived hearing problems, or by using clinical office tests such as whispered voice, finger rub, or audiometry. Audiometry in the family medicine clinic setting is a relatively simple procedure that can be interpreted by a trained health care professional. Pure-tone testing presents tones across the speech spectrum (500 to 4,000 Hz) to determine if the patient's hearing levels fall within normal limits. A quiet testing environment, calibrated audiometric equipment, and appropriately trained personnel are required for in-office testing. Pure-tone audiometry may help physicians appropriately refer patients to an audiologist or otolaryngologist. Unilateral or asymmetrical hearing loss can be symptomatic of a central nervous system lesion and requires additional evaluation.
Segmentation of bionano images for understanding cell dynamics (2005)

The use of quantum dots (QDs) and molecular beacons (MBs) is a recent advance in the field of nanotechnology. These techniques have enabled us to detect a single molecule in a cell, which helps in understanding the dynamics of a cell. The success of these techniques depends on the accurate and efficient analysis of the imaging data these techniques produce. The processing involves--segmentation of the particles, colocalisation and their tracking over multiple frames in 2D and 3D space. In this paper we have used the active contour models: snakes and their variation--GVF (gradient vector field) snakes for segmentation of nano(QD) and cell(MB) images. The results of segmentation have been used to measure the degree of colocalisation for quantum dot images and the gene expression values for molecular beacon images.