gebhart/patrepeval huggingface dataset:
Azoloquinoxaline N-oxides (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzoloquinoxaline N-oxidesBerkeley W. Cue Jr., Leonard J. Czuba, and John P. DirlamCite this: J. Org. Chem. 1978, 43, 21, 4125–4128Publication Date (Print):October 1, 1978Publication History Published online1 May 2002Published inissue 1 October 1978https://doi.org/10.1021/jo00415a030RIGHTS & PERMISSIONSArticle Views117Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (564 KB) Get e-Alerts Get e-Alerts
Economic Expansion in the Byzantine Empire, 900â€“1200 (1990)

In this book Dr Harvey shows that, if we broaden our comprehension of feudalism, the economic developments of the Byzantine Empire and of the medieval west were far more comparable than Byzantine historians have been prepared to admit. Previous interpretations have linked economic trends too closely to the political fortunes of the state, and have consequently regarded the twelfth century as a period of economic stagnation. Yet there is considerable evidence that the empire's population expanded steadily during the period covered by this book, and that agricultural production was intensified. A wealth of evidence serves to reinforce the point that the disintegration of the empire in the late twelfth century should no longer be associated with economic decline. Dr Harvey's conclusions, in particular that there is no incompatibility between the development of the landed wealth of a feudalising aristocracy and the growth of commerce and urbanisation, will affect all future interpretations of Byzantine history.
Theoretical &amp; experimental analysis of the Non Markov Parameter to detect low frequency synchronisation in time series analysis (2011)

A theoretical investigation into the behaviour of the Non-Markov Parameter is performed from a signal processing perspective in contrast to previous methodologies based on stochastic processes theory. The results indicate that the NMP can be regarded as an informational metric which is indicative of the degree of low frequency synchronisation in a complex system. These results have deep implications for physiological analysis of biological systems where the presence of sychronisation is often a marker of pathological functioning. The NMP measure is then applied to in vivo micro-electrode recordings from the subthalamic nucleus.
Effects of gelonin immunoconjugate of monoclonal antibody MSN-1 to endometrial adenocarcinoma on antigen-producing tumor cells in vitro (1997)

Missile therapy, which destroys cancer cells specifically, has been considered to be an effective modality for treatment of carcinoma. We have developed a monoclonal antibody MSN-1 (immunoglobulin class: IgM), of which the immunogen is the endometrial adenocarcinoma cell line SNG-II, which strongly reacts with endometrial adenocarcinomas. We describe an immunoconjugate consisting of the MSN-1 and a plant hemitoxin named gelonin which has revealed to assume selective cytotoxicity against the SNG-II in a colony formation assay in vitro. The results of our study suggest that the 'inhibitory concentration' or IC50, of the MSN-1-gelonin immunoconjugate against the SNG-II was 188 fold that of gelonin alone. These results indicated that the MSN-1-gelonin immunoconjugate exhibited highly selective cytotoxicity to endometrial adenocarcinoma, which expressed an epitope against the MSN-1, and it is suggested that the MSN-1-gelonin immunoconjugate has possibility of clinical application to treatment of endometrial adenocarcinomas.
Oocyte cryopreservation and in vitro culture affect calcium signalling during human fertilization (2013)

This work was supported by a clinical research mandate from the Flemish Foundation of Scientific Research (FWO-Vlaanderen, FWO09/ASP/063) to F.V.M, a fundamental clinical research mandate from the FWO-Vlaanderen (FWO05/FKM/001) to P.D.S and a Ghent University grant (KAN-BOF E/01321/01) to B.H. The authors have no conflict of interest to declare.
Use-Dependent Effects of the Class III Antiarrhythmic Agent NE-10064 (Azimilide) on Cardiac Repolarization (1995)

We studied the effects of NE-10064 (azimilide), a new antiarrhythmic agent reported to be a selective blocker of the slowly activating component of the delayed rectifier, IKs. In ferret papillary muscles, NE-10064 increased effective refractory period (ERP) and decreased isometric twitch tension in a concentration-dependent manner (0.3-30 microM). Increases in ERP showed reverse use-dependence, and were greater at 1 than at 3 Hz. In contrast, changes in tension were use dependent, with larger decreases observed at 3 than at 1 Hz. In guinea pig ventricular myocytes, NE-10064 (0.3-3 microM) significantly prolonged action potential duration (APD) at 1 Hz. At 3 Hz, NE-10064 (0.3-1 microM) increased APD only slightly, and at 10 microM decreased APD and the plateau potential. NE-10064 potently blocked the rapidly activating component of the delayed rectifier, IKr (IC50 0.4 microM), and inhibited IKs (IC50 3 microM) with nearly 10-fold less potency. NE-10064 (10 microM) did not block the inward rectifier potassium current (IKl). NE-10064 (10 microM) blocked the L-type calcium current (ICa) in a use-dependent manner; block was greater at 3 than at 1 Hz. We conclude that (a) NE-10064's block of potassium currents is relatively selective for IKr over IKs, (b) NE-10064 inhibits ICa in a use-dependent fashion, and (c) NE-10064's effects on ERP and tension in papillary muscle as well as APD and action potential plateau level in myocytes may be explained by its potassium and calcium channel blocking properties.
Modulation of polyamine-biosynthetic activity by <i>S</i>-adenosylmethionine depletion (1988)

The methionine-analogue inhibitor of S-adenosylmethionine (AdoMet) synthetase, L-2-amino-4-methoxy-cis-but-3-enoic acid (L-cisAMB), was used to study the early effects of AdoMet depletion on polyamine biosynthesis. In the presence of decreased methionine (30 microM) in the medium, treatment of cultured L1210 cells with 1 mM-L-cisAMB resulted in a near-total (95%) depletion of cellular AdoMet pools by 4 h. This was accompanied by a 3-fold increase in ornithine decarboxylase (ODC) activity, a 2.5-fold increase in AdoMet decarboxylase (AdoMetDC) activity and a 20% decrease in spermidine and spermine pools. The increase in enzyme activities seemed to be partially due to prolongation of enzyme activity half-life, since that of ODC was extended from 30 to 50 min and that of AdoMetDC from 65 to 310 min. By temporal sequence characterization (0-4 h), the onset of elevations of enzyme activity (0.5-1 h) seemed to be causally related to an earlier (0-0.5 h) decline in AdoMet pools, as opposed to the 20% decrease in spermidine and spermine pools, which occurred much later (2-4 h); the latter are known to regulate decarboxylase activities negatively. Drug-induced elevations in ODC and, to a lesser extent, AdoMetDC activities were reversed by later treatment with exogenous AdoMet. However, because the latter also increased spermine pools (which could not be prevented with various enzyme inhibitors), the reversal of elevations in enzyme activities could not be directly linked to AdoMet. Although not definitive, the data raise the interesting possibility that, in addition to being negatively regulated by polyamines, ODC and AdoMetDC activities may also be subject to negative control by cellular AdoMet (or an AdoMet metabolite). The net effect of either or both of these influences would be to conserve polyamine-biosynthetic activity in the face of declining AdoMet supplies.
Backscattering from empty and water-filled tilted cylindrical shells due to leaky helical flexural waves: Comparison and ray theory (2001)

For tilt angles smaller than the meridional ray coupling condition previously investigated [S. F. Morse et al., J. Acoust. Soc. Am. 103, 785–794 (1998)], helical rays on empty and water-filled steel shells can significantly enhance the backscattering. These contributions are compared and modeled in the present work. Such contributions in the water-filled case are found to be weaker in amplitude, which is to be expected since additional energy is lost through radiation leaked to the inner fluid. A modified ray theory taking into account the increased radiation damping was compared with experimental results for the earliest helical wave arrival, yielding satisfactory agreement. However, the energy lost to the interior of the shell may be at least partially recovered, as internal rays can excite additional leaky waves on the shell. Contributions from rays with one internal chord inside the cylinder were superposed with those of the first helical wave, and the resulting backscattering amplitude was nearly that of the air-filled case for the first helical wave alone. This shows that we may regard the ray theory for the empty shell as an upper bound for corresponding amplitudes observed in the water-filled case. [Work supported by ONR.]
Gyrofibre pour le spatial (2018)

UO f ts, '! .'w,.1 1' 1,' 0IW4'1-atr)d 111
DONOR-SPECIFIC ANTIBODIES IN RENAL ALLOGRAFT RECIPIENTS (1984)

Donor-specific alloantibody was monitored in recipients of 81 renal allografts by 51Cr release assays. Complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity were both followed. In addition to the conventional lymphoid target cells non-lymphoid target cells, namely fibroblasts from the donor, were used. Although antibody against donor lymphoid cells was found more frequently, associations with graft loss and with rejection were greater with antibody against fibroblasts. The superior association of antibody against fibroblasts with clinical events suggests that wider use of nonlymphoid target cells would be of value in studies of alloantibody responses in renal transplant recipients.
Crystal‐to‐Crystal Transformation of Magnets Based on Heptacyanomolybdate(III) Involving Dramatic Changes in Coordination Mode and Ordering Temperature (2012)

Two for one: Two unusual magnets based on the [Mo(CN)7]4− building block with MnII linkers have been prepared with different topological 3D networks. Conversion of one into the other is triggered by dehydration during a single-crystal to single-crystal event (see picture; Mn: dark red, Mo: pink, C: green, N: blue, O: red).
Functional Expression of Nitrile Hydratase in Escherichia coli: Requirement of a Nitrile Hydratase Activator and Post-Translational Modification of a Ligand Cysteine (1999)

The nitrile hydratase (NHase) from Rhodococcus sp. N-771 is a photoreactive enzyme that is inactivated on nitrosylation of the non-heme iron center and activated on photo-dissociation of nitric oxide (NO). The nitrile hydratase operon consists of six genes encoding NHase regulator 2, NHase regulator 1, amidase, NHase α subunit, NHase ú subunit and NHase activator. We overproduced the NHase in Escherichia coli using a T7 expression system. The NHase was functionally expressed in E. coli only when the NHase activator encoded downstream of the ú subunit gene was co-expressed and the transformant was grown at 30°C or less. A ligand cysteine, αCysll2, of the recombinant NHase was also post-translationally modified to a cysteine-sulfinic acid similar to for the native NHase. Although another modification of αCysll4 could not be identified because of the instability under acidic conditions, the recombinant NHase could be reversibly inactivated by nitricoxide
ChemInform Abstract: 1‐(Alkylthio)‐polyfluoroalkynes. Reactions with Mercaptans and Thermal Transformations. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thermally Tuned Resonant Optical Filters Fabricated in Amorphous Silicon (2011)

A thermo-optic tunable shallow-grating guided-mode resonance filter is designed and fabricated. The experimental filter has a spectral width of 7 nm and a tuning range of 13 nm with a tuning efficiency of 0.13 nm/°C.
NMR Studies of Tris-Intercalation: Solution Structure and Interaction of d(CTTCGCGCGAAG) with an Acridine Trimer (1988)

Tris-intercalation of an acridine trimer into the self-complementary dodecanucleotide d(CTTCGCGCGAAG) has been studied, in solution, by means of 1H and 31P nuclear magnetic resonance. In a first step all the non-exchangeable protons (except H5', H5"), the imino protons and seven of the eleven phosphorus have been assigned. The dodecanucleotide is shown to adopt a double helical B-type structure. Most of the sugar puckers are in the O1'endo range, those of the internal guanosines being closer to C2'endo. Deviations from the canonical B structure are observed in the base stacking and the phosphodiester torsional angles at the 3T4C5G stretch. The addition of an acridine trimer to the base-paired dodecanucleotide leads to the conclusion that the trimer, which is in slow exchange at the NMR time scale, tris-intercalates into the three C(3'-5')G sites of the central core, according to the excluded site model. This is evidenced by the large (1.4 ppm) upfield shift experienced by the imino protons of the three internal guanines and the shielding undergone by the acridine ring protons. Tris-intercalation is also supported by the downfield shift experienced by 6 out of the 22 phosphorus. Two of them are shifted by nearly 2 ppm, a shift range reported for oligonucleotides complexed to actinomycin D; this suggests that the structure of the backbone of the dodecanucleotide is altered.
Synthesis of Dihydrohelminthosporic Acids and their Plant Growth-promoting Activity (1965)

Journal Article Synthesis of Dihydrohelminthosporic Acids and their Plant Growth-promoting Activity Get access Saburo Tamura, Saburo Tamura Department of Agricultural Chemistry, The University of Tokya, Bunk yo-ku, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Akira Sakurai Akira Sakurai Department of Agricultural Chemistry, The University of Tokya, Bunk yo-ku, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 29, Issue 6, 1 June 1965, Pages 595–596, https://doi.org/10.1080/00021369.1965.10858433 Published: 01 June 1965 Article history Received: 23 April 1965 Published: 01 June 1965
Aspects of dynamically reconfigurable logic (1999)

Field programmable logic has thrived by offering an alternative technology for the realisation of conventional digital systems. The combination of user programmability, and rapidly increasing levels of logic integration and operating speeds, explains the continued success of field programmable devices. Reconfigurable logic, and especially dynamically reconfigurable logic, are categories of field programmable logic that can be used to extend the design space to create digital systems with distinctly new characteristics. This paper adopts a broad perspective on dynamically reconfigurable logic. It presents the current state-of-the-art before identifying and classifying the principal challenges that must be overcome if dynamically reconfigurable logic is to be exploited successfully. FPGAs are interpreted as one class of array architectures and the experiences of development with previous array architectures are assessed in the context of dynamically reconfigurable logic. The dominant role of the von Neumann, stored program computer as the principal model for programmable systems and its sometimes detrimental effect on research into dynamically reconfigurable logic are discussed. The design process for dynamically reconfigurable logic requires that logical and physical design perspectives be considered simultaneously. This has been at odds with established design methodologies for mask programmed ASICs and FPGAs. However, with the advent of deep sub-micron ASICs, the need to couple logical and physical design more closely is now clearly recognised and is further reinforced by the move towards design re-use of intellectual property in the era of system on chip. Since design tools for mask programmed ASICs heavily influence tools for FPGAs, this trend is evaluated in the context of the development of dynamically reconfigurable logic. Finally, the paper offers a conjecture for the future of reconfigurable logic. (5 pages)
A Liquid-Metal Polarization-Pattern-Reconfigurable Dipole Antenna (2017)

An electrically actuated reconfigurable liquid-metal dipole antenna is presented. Using electrocapillary actuation, a 5 VDC signal can actuate the liquid metal Galinstan into five discrete states with varying polarizations and null directions. Local surface-energy wells built into the polyimide fixture encasing the fluids enable metastable locking of the Galinstan, eliminating the need for a continuous dc bias voltage to maintain each state.
endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients (2010)

Background: The endocannabinoids, anandamide and 2-AG, are produced by adipocytes, where they stimulate lipogenesis via cannabinoid CB 1 receptors and are under the negative control of leptin and insulin. Endocannabinoid levels are elevated in the blood of obese individuals and nonobese type 2 diabetes patients. To date, no study has evaluated endocannabinoid levels in subcutaneous adipose tissue (SAT) of subjects with both obesity and type 2 diabetes (OBT2D), characterised by similar adiposity and whole body insulin resistance and lower plasma leptin levels as compared to non-diabetic obese subjects (OB). Design and Methods: The levels of anandamide and 2-AG, and of the anandamide-related PPARα ligands, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), in the SAT obtained by abdominal needle biopsy in 10 OBT2D, 11 OB, and 8 non-diabetic normal-weight (NW) subjects, were measured by liquid chromatography-mass spectrometry. All subjects underwent a hyperinsulinaemic euglycaemic clamp. Results: As compared to NW, anandamide, OEA and PEA levels in the SAT were 2-4.4-fold elevated (p < 0.05), and 2-AG levels 2.3-fold reduced (p < .05), in OBT2D but not in OB subjects. Anandamide, OEA and PEA correlated positively (p < .05) with SAT leptin mRNA and free fatty acid during hyperinsulinaemic clamp, and negatively with SAT LPL activity and plasma HDL-cholesterol, which were all specifically altered in OBT2D subjects. Conclusions: The observed alterations emphasize, for the first time in humans, the potential different role and regulation of adipose tissue anandamide (and its congeners) and 2-AG in obesity and type 2 diabetes.
Suppression of Contact Force Fluctuation of Pantograph Using Active Control (2016)

The authors have been working on the development of an active control pantograph which aims to reduce the contact force fluctuation between catenaries and a pantograph in order to improve the current collection performance for a higher speed operation. The actuation force is given as a sinusoidal waveform whose frequency follows the target frequency defined as the ratio of the train speed divided by a span length. This means that the active control pantograph aims at the reduction of the contact force fluctuation at the target frequency. To this end, a control method including an automatic tuning algorithm for the amplitude and the phase of the actuation force has been developed. In this study, performance of the developed control method is evaluated by using the pantograph/catenary hybrid simulation system which is developed by the authors. The hybrid simulation system can simulate the conditions that the active control pantograph runs with varying the running speed or runs under the catenary whose span lengths are non-uniform. The results of the evaluation tests show that the active control pantograph with the developed control method properly works and results in more than 40% decrease in the contact force fluctuation around the target frequency domain under a speed varying condition and a non-uniform span length condition.
Ellipticity of the cross section of a glass capillary formed by narrowing a cylindrical tubular billet (2013)

The effect of two process parameters—the azimuthal inhomogeneity of the wall thickness (thickness nonuniformity) of the tubular billet and the azimuthal inhomogeneity of the temperature field of the high-temperature furnace—on the ellipticity of the cross section of a drawn capillary have been experimentally investigated. Thin-wall tubes made from SL-97-1 vacuum glass were used in the experiments. It was established that the thickness nonuniformity of the capillary coincides with that of the tubular billet when a furnace with an azimuthally homogeneous temperature field is used, regardless of the “subcollapse” (incomplete collapse) of the tubular billet as it narrows into a capillary. However, the ellipticity of the drawn capillary, on the contrary, depends on the subcollapse, increasing as it increases. Azimuthal inhomogeneity of the temperature field causes appreciable ellipticity of the cross sections even in capillaries drawn from tubular billets with small thickness nonuniformity.
Higher Order Wave Loading on Fixed, Slender, Surface-Piercing, Rigid Cylinders (1991)

Abstract The use of Morison's equation together with the linear wave theory is considered a first approximation to evaluate the inline wave forces on a surface-piercing cylinder. Significant second-order forces are expected to arise from the waterline and dynamic pressure effects, even when a wave is described by the linear theory. Experiments have been carried out at the MUN (Memorial University of Newfoundland) wave tank facility to identify these second-order forces for various wave frequencies and for various cylinder diameters. A strain gage force transducer has been used for this purpose. First and second-order force components have been identified using a Fast Fourier Transform. Theoretical evaluation of wave forces involved computing components from Morison’s equation using second-order Stokes theory. The waterline forces and convective acceleration forces which contribute toward the total second-order force have also been evaluated. First-order results are in acceptance with previously established data. Theoretical considerations for second order are satisfactory. Scatter in second-order experimental results were observed. Different approaches to the second-order inertia force are compared. It is expected that the inclusion of second-order forces will lead to a better representation of wave loading on offshore structures.