gebhart/patrepeval huggingface dataset:
Gas Phase Two-Photon Spectroscopy of Polyazines: Pyrazine (1979)

Abstract The two-photon excitation spectra of gas phase pyrazine-h 4 and -d 4 in the region of the S 1 ←S 0 transition are presented. The two-photon absorption which is electronically forbidden is induced by-various vibrations of ungerade parity. Because of the different selection rules for two-photon transitions hitherto unknown vibrational frequencies in the excited state 1 B 3u have been determined.
Roll-Forward Recovery with State Estimation (2011)

We propose and analyze a novel roll-forward recovery scheme that is based on state estimation. In this solution, a dedicated monitoring component has the capability to predict future states of the physical environment by periodically analyzing the state of an associated monitored component. These predictions can serve either directly as restart states for a failed component or as facilitators of the recovery process. Our solution combines three key concepts: identification and handling of a component's ground state, resilience of service users to occasional but bounded service outage, and state estimation. The main benefit of the proposed scheme is that it avoids replication and thus provides responsive recovery for components that lack the property of replica-determinism. The aim of this work is recovery of time-critical but not safety-critical components in mixed-criticality real-time systems. We show that the proposed recovery scheme has comparable error-detection and repair efficiency to roll-forward recovery with behavior-based checks introduced by Xu and Randell.
Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats (2006)

Both platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) are known to be pivotal cytokines in liver fibrosis development. The aim of our current study was to elucidate the effects of dual inhibition of PDGF and TGF-beta by combination of the clinically used imatinib mesylate (STI-571) and perindopril (an ACE-inhibitor; ACE-I), respectively, on ongoing liver fibrosis development in rats. The effects of STI-571 and ACE-I at clinically comparable low doses were examined in a rat model of CCl4-induced liver fibrogenesis. Treatment with both STI-571 and ACE-I inhibited liver fibrogenesis and suppressed activation of hepatic stellate cells (HSCs). Administration of both agents exerted a more potent inhibitory effect than administration of either single agent. Our in vitro study demonstrated that STI-571 and ACE-I suppressed PDGF receptor (PDGFR) phosphorylation and TGF-beta expression in activated HSCs, respectively. Dual suppression of PDGF and TGF-beta with a combination of clinically comparable low doses of STI-571 and ACE-I exerted a significant inhibitory effect on ongoing liver fibrosis development. Since both agents are widely used in clinical practice, this combination therapy may provide a new strategy against liver fibrosis in the future.
Fractionation of Plasmodium knowlesi-induced antigens of rhesus monkey erythrocyte membranes. (1979)

In order to characterize parasite-induced host cell membrane antigens, the plasma membranes of Plasmodium knowlesi-infected rhesus erythrocytes have been compared with those of normal red cells and purified schizonts by immunochemical and biochemical techniques. Host cell membranes and schizonts were separated by differential centrifugation following nitrogen decompression. Isolated schizonts were further fractionated into several subcellular compartments. Crossed-immune electrophoresis, against monkey anti-schizont serum, of Triton X-100-solubilized material identified 7 P. knowlesi-specific antigens, of which 4 could be detected only in the host cell membranes. These membranes also contained 3 proteins, with relative molecular masses of 55 000, 65 000 and 90 000 and isoelectric points at pH 4.5, 4.5 and 5.2, respectively, which are lacking in normal membranes. Pulse-chase experiments with ((14)C)-glucosamine showed that these parasite-induced host cell membrane components are glycoproteins.
Some highlights of virus research in 1989 (1990)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Molecular and Bioinformatic Evidence of Hepatitis C Virus Evolution in Brain (2008)

This study introduces novel methods for assessing RNA from postmortem samples. It increases the reported cases of HCV in the brain, provides the first E1 sequences from the brain, and contributes to the growing evidence that HCV replicates and evolves within the brain.
Synthesis of Oligodeoxyribonucleotides Containing Analogs of O6-Methylguanine and Reaction with O6-Alkylguanine-DNA Alkyltransferase (1994)

O6-Alkylguanine-DNA alkyltransferase (AGT) repairs the mutagenic O6-methylguanine (O6-mG) lesion by transferring a methyl group from the 6-position of guanine to a cysteine residue on the protein. The simplest possible mechanism is an SN2 process in which the cysteine displaces the methyl group off of the guanine in a concerted reaction. To probe the interactions between the protein and guanine leaving group, oligodeoxynucleotide duplexes containing analogs of O6mG were synthesized and then reacted with AGT. The analogs, which were incorporated into deoxynucleotides include O6-methylhypoxanthine (O6-mH),S6-methyl-6-thioguanine (S6mG),S6-methyl-6-thiohypoxanthine (S6mH),Se6-methyl-6-selenoguanine (Se6mG),Se6-methyl-6-selenohypoxanthine (Se6mH), O6-methyl-1-deazaguanine (O6m1DG), O6-methyl-3-deazaguanine (O6m3DG), and O6-methyl-7-deazaguanine (O6m7DG), differ from O6mG in that the heteroatoms have been replaced so that they are poorer hydrogen bond participants and proton acceptors. AGT was reacted with oligonucleotide duplexes of the sequence 5'-GGC GCT XGA GGC GTG-3' in which X was O6mG or an analog in which X was paired with C. The reactions in 50 mM Tris-HCl and 1 mM EDTA, pH7.6 and 37 degrees C, were followed by anion-exchange HPLC in 10 mM NaOH with a NaCl gradient. All detected reactions were demethylations of the oligodeoxynucleotides except for O6m3DG, which reacted in an unknown manner.(ABSTRACT TRUNCATED AT 250 WORDS)
ChemInform Abstract: POLYFLUORCYCLOPENTADIENE 7. MITT. RK. VON PHENYLAZID MIT 2,3,4,5,5,6‐HEXAFLUOR‐TRICYCLO(5,2,1,0(2,6))DECADIEN‐(3,8)ENDO‐PERFLUOR‐TRICYCLO(5,2,1,0(2,6))DECADIEN‐(3,8) UND ′LONG‐RANGE′‐(19)F‐(19)F‐KOPPLUNGEN IM PRODUKT DES LETZTEREN (1971)

Abstract Der Hexafluortricyclus (I) reagiert mit Phenylazid bei Zimmertemperatur zu den isomeren Triazolinen (II) und (III).
Hindered Amines. Preparation and Reactions of Some Secondary Acetylenic Amines<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHindered Amines. Preparation and Reactions of Some Secondary Acetylenic Amines1NELSON R. EASTON, ROBERT D. DILLARD, WILBUR J. DORAN, MABEL LIVEZEY, and DWIGHT E. MORRISONCite this: J. Org. Chem. 1961, 26, 10, 3772–3776Publication Date (Print):October 1, 1961Publication History Published online1 May 2002Published inissue 1 October 1961https://pubs.acs.org/doi/10.1021/jo01068a035https://doi.org/10.1021/jo01068a035research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Numerical Analysis of Three-Dimensional Sound Field in a Duct with Eccentric Slit-Like Expansion. (1999)

A numerical analysis is developed to the three-dimensional sound field in cylindrical duct with eccentric slit. A linearized unsteady Euler equation for acoustic disturbance is solved by a fourth-order accurate finite difference method. The boundary conditions at the curved rigid surface, such as the duct wall, are implemented properly for the linearized Euler equations. The three-dimensional structures of the sound fields are obtained for the several eccentricities of slit. The computed result shows that each eccentric slit has two different resonant frequencies, which are fully consistent with our previous experimental data.
The SH3, HOOK and guanylate kinase‐like domains of hDLG are important for its cytoplasmic localization (2002)

These results suggest that the SH3, HOOK and GK domains of hDLG are important for its cytoplasmic localization.
RAPD marker estimation of genetic structure among isolated northern leopard frog populations in the south‐western USA (1996)

Amphibians in the south-western United States are currently experiencing population declines. Causal explanations for these population changes as well as the implementation of sound management practices requires an understanding of the genetic structure of natural amphibian populations. To this end, we estimated genetic differences within and among seven isolated populations of northern leopard frogs, Rana pipiens, from Arizona and southern Utah using random amplified polymorphic DNA (RAPD) analyses. Fourteen arbitrarily designed primers detected 38 polymorphic loci in 85 individual frogs. Three types of population structure were observed in this study. (i) Two populations showed low genetic diversity (D = 0.10 and 0.04) and may have been established by relatively recent events. (ii) Two were not genetically distinct and exhibited a high degree of within-population diversity (D = 0.35). The possibility of gene flow between these populations is high due to their geographical proximity and their shared genetic structure. (iii) Three populations were genetically distinct from each other and the other populations, and exhibited intermediate within-population variation (D = 0.19, 0.17, 0.14). Genetic distances among the seven populations ranged from 0.00 to 0.20, suggesting that some of these leopard frog populations are genetically distinct. Although based on relatively small samples, these data suggest that leopard frog populations in the south-west are likely to represent unique genetic entities worthy of conservation. The management implications of these results are that isolated leopard frog populations should be evaluated on an individual basis to best preserve them.
A Study on Rapid Mold Heating System using High-Frequency Induction Heating (2007)

Rapid mold heating has been recent issue to enable the injection molding of thin-walled parts or micro/nano structures. Induction heating is an efficient way to heat a conductive workpiece by means of high-frequency electric current caused by electromagnetic induction. Because the induction heating is a convenient and efficient way of indirect heating, it has various applications such as heat treatment, brazing, welding, melting, and mold heating. The present study covers an experimental investigation on the rapid heating using the induction heating and rapid cooling using a vortex tube in order to eliminate an excessive cycle time increase. Experiments are performed in the case of a steel cup mold core with various heating and cooling conditions. Temperature is measured during heating and cooling time, from which appropriate mold heating and cooling conditions can be obtained.
A constant-time parallel sorting algorithm and its optical implementation (1995)

High-speed electronic sorting networks are difficult to implement with VLSI technology because of the dense and global connectivity required. Optics eliminates this bottleneck by offering global interconnections, massive parallelism, and noninterfering communications. We present a parallel sorting algorithm and its efficient optical implementation using currently available optical hardware. The algorithm sorts n data elements in a few steps, independent of the number of elements to be sorted. Thus, it is a constant-time sorting algorithm, that is, O(1) time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Serum Autoantibodies to Optic Nerve Head Glycosaminoglycans in Patients With Glaucoma (1999)

These autoantibodies may increase the susceptibility of the optic nerve head to damage in these patients by changing the functional properties of the lamina cribrosa, its vasculature, or both.
Temperature and Chain Length Effects on Bending Elasticity of Phosphatidylcholine Bilayers (1994)

A strong decrease of the bilayer bending elastic modulus, kc, has been experimentally established for dimyristoyl and dipalmitoyl phosphatidylcholine, when the liquid-crystal-gel phase transition temperature is approached from above. This phenomenon may be due to local-curvature-induced changes in the transition temperature. In the liquid-crystal phase, the bending modulus, kc, significantly increases as a function of the lipid chain length for dilauryl, dimyristoyl and dipalmitoyl phosphatidylcholine.
From NDE to Prognostics: A Revolution in Asset Management for Generation IV Nuclear Power Plants (2007)

For Generation IV nuclear power plants (NPP) to achieve operational goals it is necessary to adopt new on-line monitoring and prognostic methodologies, giving operators better plant situational awareness and reliable predictions of remaining service life. Such techniques can improve plant economics, reduce unplanned outages, improve safety and provide probabilistic risk assessments. This paper reviews the state of the art and the potential impact from monitoring, diagnostics and prognostics on advanced NPP, with a focus on the needs of Generation IV systems.
Simplified single-loop full-flatness control of a hybrid power plant (2016)

This paper presents a simplified nonlinear estimation technique based on the differential flatness control strategy combined with a single-loop feedback control. An experiment setting that is hybridized between two power sources, namely, a 500-W fuel cell (FC) emulator and a 165-F supercapacitor (SC) module, was used to validate the proposed technique. Each power source was connected to a two-phase interleaved boost converter, which distributes voltage-regulated dc supplied by the hybrid power source. A dSPACE 1103 controller card interfaced the hybrid system and the control algorithm with the mathematical environment of MATLAB-Simulink. The experimental results showed the rapid response of the proposed system to the dynamic load requirement. This confirmed that the single-loop full-flatness feedback control is a potential algorithm that offers stabilization of the hybrid system sourced by FC and SC.
Bemötande i sjukvården vid missfall : kvinnors utsagor (2007)

Bakgrund: Omkring en av fyra graviditeter resulterar i missfall. Rent medicinskt är ett missfall som sker tidigt i graviditeten något som hamnar långt ner på prioriteringslistan inom sjukvården. För kvinnan däremot är det ofta en stor händelse som hon bär med sig genom hela livet och vårdpersonalens förhållningssätt kan påverka kvinnans upplevelse av missfallet. Syfte: Syftet med denna studie var att belysa kvinnors utsaga om vårdpersonalens bemötande vid ett missfall. Metod: Litteraturstudie av två självbiografiska böcker som behandlar ämnet missfall. En kvalitativ analys har använts och böckerna analyserades med inspiration av Burnards analysmetod för att uppnå syftet. Resultat: Presenteras i fem kategorier: Behov av att sjukvårdspersonal känner till kvinnans framtidsdrömmar, bemötande, behov av att sjukvårdspersonal vet att kvinnan upplever en förlust av kontroll, behov av att sjukvårdspersonal känner till kvinnans förlust av identitet och behov av stöd. Resultatet visar att det är viktigt att sjukvårdspersonalen även ser till kvinnans emotionella behov och inte enbart till de fysiska behoven vid missfallet. Det är betydelsefullt att sjukvårdspersonalen förstår att missfallet är en komplex händelse som får följder på många olika plan hos kvinnan. Slutsats: Bemötandet och det emotionella stödet är något som vårdpersonalen inte får glömma bort. Bemötandet kvinnan får visar sig ha betydelse för hur kvinna senare kommer att se på sitt missfall.
Sezione III. Il contesto extraeuropeo : Capitolo 7. Content-based Description of Multi-dimensional Objects using an Invariant Representation of an Associated Riemannian Space (2004)

This chapter presents a new theoretical approach for the description of multi-dimensional objects. These objects are characterized by various attributes such as speed, mass density and electromagnetic field distributions. The approach consists of the following steps. Firstly, a tensor is associated with the energy-momentum (mass + motion + field) content of each object. Secondly, a Riemannian space is built from this tensor. Next, a set of invariant quantities is constructed from the Riemannian curvatures associated with the Riemannian space from which a new statistical representation is built. This representation is invariant under arbitrary coordinate transformations and can describe both static and dynamic objects. The proposed approach can be generalized to a large number of different types of object by applying a variational principle.
SPLITTING STRESSES IN CONCRETE FLANGES OF EDGE GIRDERS IN BRIDGE DECKS (2001)

Since the literature does not seem to report a direct method of calculating transverse tensile, or splitting, stresses in concrete flanges of composite beams, many design codes require the calculation of the shear strength of the flanges at their junction with the web. By using elementary concepts of the strength of materials, a direct method has been developed for calculating the splitting stresses. The validity of the proposed method has been established with the help of finite element results, as well as those obtained from a test on a physical model. (A)
Significance of Escherichia coli serotypes in wastewater effluent. (1967)

The Waste Water Renovation and Conservation Research Project at the Pennsylvania State University was initiated in 1962 to find an alternative to the present techniques of disposal of effluent from wastewater treatment plants into streams. This inter disciplinary program in the Institute for Science and Engineering currently is aimed at determining the feasibility of a nonaqueous means of effluent dis posal by use of the biological and physical-chemical processes in soils and geologic deposits (1). This is accom plished by pumping the chlorinated effluent to the University Forest and Agronomic Cropland Sites through a 2.5-mile (4-km) trunk line. In the agronomic area the effluent is applied at levels of 1 and 2 in./wk (2.5 and 5.1 cm/wk) on plots 240 X 800 ft (73 X 244 m), each containing 7 strips of crops. The effluent is applied at a rate of 0.25 in./hr (0.63 cm/hr) through rotating sprinklers. The object of this study was to evaluate the significance of the sur vival of Escherichia coli serotypes in the wastewater effluent. This included a comparison of the serotypes isolated from the raw sewage with those found in the chlorinated effluent as it left the plant, as it was sprayed in the field, and as it percolated through the soil. In addition, a survey was made to determine the E. coli serotypes present in wild birds in the sprayed area.
Exploratory Analysis of Brigatinib Activity in Patients With Anaplastic Lymphoma Kinase-Positive Non–Small-Cell Lung Cancer and Brain Metastases in Two Clinical Trials (2018)

Purpose In patients with crizotinib-treated, anaplastic lymphoma kinase gene ( ALK)-rearranged non-small-cell lung cancer (ALK-positive NSCLC), initial disease progression often occurs in the CNS. We evaluated brigatinib, a next-generation ALK inhibitor, in patients with ALK-positive NSCLC with brain metastases. Patients and Methods Patients with ALK-positive NSCLC received brigatinib (90 to 240 mg total daily) in a phase I/II trial (phI/II; ClinicalTrials.gov identifier: NCT01449461) and in the subsequent randomized phase II trial ALTA (ALK in Lung Cancer Trial of AP26113; ClinicalTrials.gov identifier: NCT02094573; patients in arm A received 90 mg once daily; patients in arm B received 180 mg once daily with 7-day lead-in at 90 mg). Primary end points (systemic objective response rates [ORRs]) were previously reported. Independent review committees assessed intracranial efficacy in patients with baseline brain metastases. Results Most patients with ALK-positive NSCLC had baseline brain metastases (50 of 79 [63%], phI/II; 80 of 112 [71%] and 73 of 110 [66%] in ALTA arms A and B, respectively), many of whom had no prior brain radiotherapy (23 of 50 [46%], phI/II; 32 of 80 [40%], ALTA arm A; 30 of 73 [41%], arm B). All patients, except four in phI/II, had received crizotinib. Among patients with measurable (≥ 10 mm) brain metastases, confirmed intracranial ORR was 53% (eight of 15; 95% CI, 27% to 79%) in phI/II, 46% (12 of 26; 95% CI, 27% to 67%) in ALTA arm A, and 67% (12 of 18; 95% CI, 41% to 87%) in arm B. Intracranial ORRs were similar in subsets without prior radiation or progression postradiation. Among patients with any baseline brain metastases, median intracranial progression-free survival (iPFS) was 14.6 months (95% CI, 12.7 to 36.8 months), phI/II; 15.6 months (95% CI, 9.0 to 18.3 months), ALTA arm A; 18.4 months (95% CI, 12.8 months to not reached), ALTA arm B. Conclusion Brigatinib yielded substantial intracranial responses and durable iPFS in ALK-positive, crizotinib-treated NSCLC, with highest iPFS in patients receiving 180 mg once daily (with lead-in).
Das kolorektale Karzinom (KRK) beim jungen Patienten – ist das Alter ein prognostischer Faktor? (2013)

The general assumption of a poorer prognosis in younger patients with CRC could not be confirmed. Younger patients have a poorer histological subtype of carcinoma. But this is compensated by the better overall condition, less comorbidities, faster postoperative recovery and an optimally organised post-operative (adjuvant, therapeutic or palliative) therapy. In summary, younger patients have a better observed survival but - considering differences in life expectancy - a similar relative survival.
The structure of highly oriented high modulus polyethylene (1992)

Abstract A comparative study of the structure of uniaxially‐oriented bulk samples of linear PE of various molecular weights over a wide range of draw ratios has been carried out by means of small and wide angle X‐ray analysis, NMR‐spectroscopy and DSC. The structure of oriented high molecular weight PE samples, prepared by drawing single crystal mats to draw ratios up to 200, have also been studied. A large number of unfolded tie‐molecules have been found to exist in the trans‐conformation in PE amorphous regions. These tie‐molecules, which connect the adjacent crystallites along the axis of orientation, and are not large crystals, account for the high mechanical properties of these samples. It has been shown that in the course of the orientation process, chain unfolding in the amorphous regions is accompanied by the formation of continuous linear systems consisting of several coherent crystallites and tie‐molecules. These are coherently aligned along the macromolecular axis.