gebhart/patrepeval huggingface dataset:
Low‐velocity impact craters in ice and ice‐saturated sand with implications for Martian crater count ages (1979)

We produced a series of decimeter‐sized impact craters in blocks of ice near 0°C and −70°C and in ice‐saturated sand near −70°C as a preliminary investigation of cratering in materials analogous to those found on Mars and the outer solar system satellites. The projectiles used were standard 0.22 and 0.30 caliber bullets fired at velocities between 0.3 and 1.5 km/s, with kinetic energies at impact between 10 9 and 4×10 10 ergs. Crater diameters in the ice‐saturated sand were ∼2 times larger than craters in the same energy and velocity range in competent blocks of granite, basalt and cement. Craters in ice were ∼3 times larger. If this dependence of crater size on strength persists to large hypervelocity impact craters, then surfaces of geologic units composed of ice or ice‐saturated soil would have greater crater count ages than rocky surfaces with identical influx histories. The magnitude of the correction to crater counts required by this strength effect is comparable to the magnitudes of corrections required by variations in impact velocity and surface gravity used in determining relative interplanetary chronologies. The relative sizes of craters in ice and ice‐saturated sand imply that the tensile strength of ice‐saturated sand is a strong inverse function of temperature. If this is true, then Martian impact crater energy versus diameter scaling may also be a function of latitude.
Novel optical fiber absorption sensor based on fluorescence lifetime encoding (1998)

Advantages of lifetime based sensors (for temperature etc.) compared to intensity sensors have been thoroughly presented in terms of intrinsicaly stable and reference-free measurements 1 . There is however a limited number of materials that have strong fluorescence lifetime dependence on desired physical or chemical property of the environment. Even smaller subset have properties such as long lifetime, high quantum efficiency and chemical stability that enable long term adecquate SNR with simple electronics and design. Vast majority of fiber optic sensors is intensity based, so the possibility of encoding absorption in the measured material in a time-dependent signal with all the advantages of a lifetime based sensors is highly desired.
Balance between IL-1 beta, TNF-alpha, and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells, and monocytes. (1995)

Patients with end-stage renal disease present an immunodeficiency that paradoxically coexists with activation of most immunocompetent cells, and the roles of chronic uremia and maintenance dialysis are poorly understood. We determined circulating levels of IL-1 beta and IL-1Ra, TNF-alpha and its soluble receptors (TNF-sR55 and TNF-sR75), and activation markers of T cells (soluble CD25), B cells (soluble CD23), and monocytes (neopterin) in a large cohort of undialyzed patients at various stages of chronic renal failure and in dialyzed patients on maintenance hemodialysis or chronic peritoneal dialysis. The progression of uremia was associated with a gradual increase in soluble CD25, CD23, and especially neopterin levels. Although IL-1 beta could not be detected, IL-1Ra levels were significantly increased from the earliest stage of renal failure. Plasma levels of TNF-alpha, TNF-sR55, and TNF-sR75 progressed with the severity of renal failure and correlated with soluble CD25, CD23, and neopterin levels, whereas IL-1Ra levels correlated exclusively with TNF-sR55 levels. Compared with undialyzed patients, levels of IL-1 beta were higher in patients on maintenance hemodialysis, whereas those of IL-1Ra were lower and decreased further at the end of dialysis sessions. In contrast, both TNF-sR55 and TNF-sR75 levels were significantly higher than in undialyzed patients and increased further at the end of dialysis sessions in the absence of an increase of TNF-alpha. Such an imbalance between cytokines and their inhibitors may play a pivotal role in the multifaceted process of immune dysfunction.
A Morphinan Alkaloid from Antizoma angustifolia (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Morphinan Alkaloid from Antizoma angustifoliaTheodor G. Dekker, Theunis G. Fourie, Elmaré Matthee, and Friedrich O. SnyckersCite this: J. Nat. Prod. 1988, 51, 3, 584Publication Date (Print):May 1, 1988Publication History Published online1 July 2004Published inissue 1 May 1988https://doi.org/10.1021/np50057a023Request reuse permissionsArticle Views77Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (98 KB) Get e-Alertsclose Get e-Alerts
Fat Repositioning in Lower Lid Blepharoplasty: The Role of Titrated Excision (2011)

These data have not been presented before. The authors report no conflicting financial interests. Correspondence: Dr. Allen M. Putterman, M.D., University of Illinois at Chicago, Illinois Eye and Ear Infirmary, 111 N. Wabash Ave., Suite 1722, Chicago, IL 60602, U.S.A. E-mail: [email protected]
Cathodoluminescence investigation of oxidized porous silicon (2003)

The luminescent emission related to the structural reconstruction of the porous silicon surface under dry oxygen atmosphere annealing was investigated by cathodoluminescence in the scanning electron microscope. The evolution of the emission bands at 420-480 nm, 590 nm and 640 nm as a function of the annealing treatments is discussed on the basis of present model of surface recombination in porous silicon.
Abstract 341: Efficient Large-scale Sarcomere Tracking (sarctrack) to Assess HCM Variants in iPSC-CMs (2019)

Variants that drive HCM and associated adverse patient outcomes are found in the cardiac sarcomere. These variants range from those that are known to be pathogenic to those that are likely pathogenic or even variants of unknown significance (VUS). CRISPR/Cas-9 engineering has accelerated our ability to generate variants in iPSC to probe changes in cellular function and assess cellular pathogenicity in VUSs. However, iPSC-CMs are not as functionally mature as adult cardiomyocytes. For this reason we have developed a platform to assess contractile function directly at the level of the sarcomere. We use a custom built MatLab algorithm to assess sarcomere length, contraction time, relaxation time, and beat rate of individual sarcomeres within iPSC-CMs. Sarcomeres are visualised using reporter lines that have been engineered with an N-terminal TTN-GFP. We assess the contractile function of thick filament variants in MYH7 and MYBPC3. We show the ability to detect changes in key contractile parameters. This platform allows the screening of pharmacological compounds against these reporter lines with engineered variants.
Classification of fixed urological cells using Raman tweezers (2009)

In this paper we report on preliminary investigations into using Raman tweezers to classify urological cell lines. This builds on earlier work within the group, whereby Raman tweezer methodologies were developed, and the application of this technique to differentiate between live prostate cancer (CaP) and bladder cells lines (PC-3 and MGH-U1 respectively) was demonstrated.In this present study we analysed chemically fixed cells using two different fixative methods; SurePath (a commercial available liquid based cytology media) and 4% v/v formalin/PBS fixatives. The study has been expanded from our previous live cell study to include the androgen sensitive CaP cell line LNCaP, primary benign prostate hyperplasia (BPH) cells as well as primary urethral cells. Raman light from the cells was collected using a 514.5 nm Ar-ion laser excitation source in back-scattering configuration mode.Principal component-linear discriminate analysis (PC-LDA) models of resulting cell spectra were generated and these were validated using a blind comparison. Sensitivities and specificities of > 72% and 90% respectively, for SurePath fixed cells, and > 93% and 98% respectively for 4% v/v formalin/PBS fixed cells was achieved. The higher prediction results for the formalin fixed cells can be attributed to a better signal-to-noise ratio for spectra obtained from these cells.Following on from this work, urological cell lines were exposed to urine for up to 12 hours to determine the effect of urine on the ability to classify these cells. Results indicate that urine has no detrimental effect on prediction results.
Candesartan cilexetil, a new generation angiotensin II antagonist, provides dose dependent antihypertensive effect. (1997)

Candesartan is a new generation angiotensin II type 1 receptor blocker, characterised by tight binding to and slow dissociation from the receptor. In order to delineate the dose-response curve for candesartan cilexetil (the orally administered prodrug), results from six European placebo-controlled, dose-response studies were pooled. These were of a double-blind, randomised, parallel group design, with a treatment duration of 4-12 weeks. A total of 1482 patients with mild to moderate primary hypertension were treated with candesartan cilexetil 2 mg (n = 80), 4 mg (n = 216), 8 mg (n = 455) or 16 mg (n = 294), or with placebo (n = 437). Blood pressure (BP) measurements were performed 24 h after dose. The differences in BP change (baseline vs end of the studies) between the placebo group and the groups treated with candesartan cilexetil were assessed using analysis of covariance and dose response curves were estimated by fitting the data to an Emax model. The placebo-corrected mean reductions in sitting diastolic BP were approximately 2.5 mm Hg with 2 mg, 4.5 mm Hg with 4 mg, 6 mm Hg with 8 mg, and 8 mm Hg with 16 mg of candesartan cilexetil. For sitting systolic BP, the placebo-corrected mean reductions were in the order of 5, 7, 10 and 12 mmHg, respectively, with 2, 4, 8 and 16 mg of candesartan cilexetil. The BP reductions were similar in the standing position with no indication of postural hypotension. Age or gender did not influence the BP response to candesartan cilexetil. In conclusion, candesartan cilexetil provides a clinically significant, dose-dependent antihypertensive effect in doses ranging from 4-16 mg once daily.
Synthesis and evaluation of a novel samarium‐153 bifunctional chelating agent for radioimmunotargeting applications (2005)

Abstract A new bifunctional chelating agent (BCA), 3‐(4‐isothiocyanatobenzyl)triethylenetetraaminehexaacetic acid ( 9 ), has been synthesized in fast and easy conditions. An improved synthesis of its position isomer 1‐(4‐isothiocyanatobenzyl)triethylenetetraaminehexaacetic acid ( 19 ) is also described. Stability in serum media of the two corresponding aminobenzyl derivatives‐samarium‐153 complexes, respectively, 3‐(4‐aminobenzyl)triethylenetetraaminehexaacetic acid—samarium‐153 and 1‐(4‐aminobenzyl)triethylenetetraaminehexaacetic acid—samarium‐153, have been evaluated. The 3‐(4‐aminobenzyl)triethylenetetraaminehexaacetic acid complex revealed excellent stability in serum media, and therefore 3‐(4‐isothiocyanatobenzyl)triethylenetetraaminehexaacetic acid ( 9 ) appears useful for future in vivo radioimmunotherapy investigations. Copyright © 2005 John Wiley & Sons, Ltd.
Bone sialoprotein is predictive of bone metastases in resectable non small cell lung carcinoma: A case–control study and prevalence data (2006)

olites of the mevalonate pathway which trigger proliferation of a subset of cytotoxic gamma, delta T cells and cytokine release.Several studies are now in progress investigating whether this immunomodulatory effect of zoledronic acid can be utilized in oncology to enhance its therapeutic potential beyond the well established inhibition of tumour-induced osteolysis.
ChemInform Abstract: Syntheses of Some Nitroimidazole Substituted Boronic Acids: Precursors to Technetium‐99m Complexes with Potential for Imaging Hypoxic Tissue. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An APL microprogramming structure (1973)

Several papers have been published (Ref. 1, 2, 3) which describe an APL machine. The APL machines by Zaks, et al and Hassitt, et al, describe a microprogrammed approach which uses pre-existing microinstruction formats and machine capabilities. No special hardware was added to enhance the execution of APL statements.
Expedition 331 summary (2011)

The Iheya North hydrothermal field is located in the middle Okinawa Trough, an actively spreading backarc basin that extends for 1200 km between the Ryukyu arc-trench system and the Asian continent in a transitional region between continental and oceanic crust. Because the Okinawa Trough contains both hemipelagic and volcanic sediment, in some places >1000 m thick, its hydrothermal systems provide abundant H 2 , CO 2 , CH 4 , NH 4 , H 2 S, and CO derived from sedimentary organic matter and from magmatic gases that could feed a variety of microbial communities, sustained by different chemolithoautotrophic primary producers within a range of subseafloor habitats. Integrated Ocean Drilling Program (IODP) Expedition 331, the Deep Hot Biosphere project, drilled into the Iheya North hydrothermal system in order to investigate metabolically diverse subseafloor microbial ecosystems and their physical and chemical settings.
ACCEPTABILITY OF SHOCK ABSORBERS FOR ROAD ROUGHNESS MEASURING TRAILERS (1987)

The accuracy of the response-type road roughness meters depends primarily on how the dynamic characteristics of the test vehicles adhere to prescribed standards. The standards for shock absorbers used in roughness-measuring vehicles as defined by ASTM are discussed in this paper. A new acceptability criterion is proposed that assures a higher overall accuracy of the measuring system and at the same time allows for larger deviations of the shock absorber parameters from the standard values. The method allows for verifying the acceptability of shock absorbers mounted in road roughness measuring vehicles. The effects of typical nonlinearities in shock absorber characteristics are also presented.
Comparison Between the Experimentally Determined Orientation Dependence of the Near Edge Structure in Electron Energy Loss Spectra from Graphite with Present Theoretical Formulations (2006)

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2005
Percutaneous Nephrostomy: Assessment of Renal Damage Associated with Semi-Rigid (24F) and Balloon (36F) Dilation (1987)

In an effort to discern the amount of renal damage incurred by antegrade percutaneous nephrostomy and nephrostomy tract dilation, we studied the long-term effect of acutely created 24F and 36F percutaneous nephrostomy tracts on 12 pig kidneys. Half of the nephrostomy tracts were dilated using a semi-rigid 24F fascial dilating system (Amplatz design) and half were dilated using a 36F balloon dilation system. Animals were killed at six weeks and the nephrostomy tract was dissected, fixed in formalin, and microscopic cross-sections were stained with Masson's trichrome stain for collagen prior to morphometry using computerized planimetry. In this study, renal damage from the nephrostomy tract averaged 0.15% of the total renal cortical surface. Balloon dilation to 36F incurred no more significant damage than fascial dilation to 24F.
Bioactivity of Metallothionein-3 Correlates with Its Novel .beta. Domain Sequence Rather Than Metal Binding Properties (1995)

Human and mouse metallothionein-3 (MT-3) molecules exhibit the same metal binding stoichiometry with Zn(II), Cd(II), or Cu(I) as MT-1 or MT-2 molecules, suggesting that MT-3 consists of two domains enfolding separate polymetallic clusters. The kinetic reactivities of Zn(II) complexes of MT-3 with the chelator ethylenediaminetetraacetic acid (EDTA) or the thiol reagent dithiobis(2-nitrobenzoic acid) (DTNB) resembles the reactivity of ZnMT-1. Furthermore, the candidate alpha and beta domain peptides of human MT-3 are very similar to MT-1 domain peptides in the reactivity of Zn(II) complexes. Zn(II) complexes of human and mouse MT-3 inhibit the survival of rat cortical neurons cultured in the presence of an Alzheimer's disease brain extract. Inhibitory activity is unique to the MT-3 isoform and is a property of the N-terminal beta domain. The inhibitory activity of the 32-residue MT-3 beta domain is abolished by a double mutation within the beta domain resulting in the conversion of the C-P-C-P sequence to either C-S-C-A or C-T-C-T. Thus, the bioactivity arises from a novel structure of the N-terminal beta domain of MT-3 and not any unusual metal-binding properties.
Nanoelectrode Arrays for in-situ Identification and Quantification of Iodine Ions. (2018)

Abstract not provided.
Medical Adhesives: Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair (Adv. Healthcare Mater. 16/2015) (2015)

Methods to deliver viscous medical glues to the tissues through small incisions or with small channels are critical for minimally invasive surgeries. Inspired by the granule-packaged glue delivery system of sandcastle worms, J. M. Karp and co-workers show on page 2587 nanoparticulate formulation of viscous hydrophobic light-activated adhesive based on poly(glycerol sebacate)-acrylate.
Effect of third carpal slab fracture and repair on racing performance in Thoroughbred horses: 31 cases (1977-1984) (1988)

Between 1977 and 1984, 31 Thoroughbred horses (mean age, 2.8 years) were surgically treated for slab fractures of the third carpal bone. All fractures involved the articular surfaces of the intercarpal and the carpometacarpal joints in a frontal plane and had a cuboidal or slab shape. In 20 of the horses, the bone was fractured during racing and in 8 of the horses, the bone was fractured during race training. The right limb was affected more frequently than was the left limb (24 vs 7, P less than 0.05). Twenty-one (67.6%) horses raced at least once after recovery from the surgery. Data were available from 11 claiming horses that had raced at least twice before their injuries and 4 times after recovery. A claiming horse is one that competes where any horse entered is subject to being purchased for the designated amount of the claiming race; therefore, each race tends to automatically attract entrants of similar ability. In this group of 11 horses, claiming value decreased from a mean of $13,900 to a mean of $6,500 (P less than 0.05), and the mean finish position was 5.8 +/- 3.16 before injury and 5.8 +/- 3.30 after recovery. The mean claiming value for horses that had not raced before injury, but had raced after recovery (n = 5) was $8,150.
Glasses with a large laser effect: Nd-phosphate and Nd-fluorophosphate (1978)

Nd-phospate glasses with a great laser effect are described. They have large induced-emission cross sections and low thermal distortion. Those glasses can be used in small and medium laser equipment for processing of materials and for measuring techniques. Addition of fluorine (fluorophosphate glasses) produces a lowering of the nonlinear refractive index. Those glasses are particularly suitable for the final stages of large amplifier chains for nuclear fusion experiments. The nonlinear refractive index can be reduced as low as 0.5 x 10(-13) esu.
A new enzymatic activity participating in the initiation of glycogen biosynthesis in rat brain. (1991)

A rat brain extract, able to synthesize from UDP-Glc an alpha-1,4-glucan covalently bound to a protein in the absence of added primer is described. The compound formed is precipitable by dilute trichloroacetic acid (TCA). In the presence of glycogen, added as primer, this molecule is enlarged and is not precipitable by TCA. Unprimed and primed activities differ in several aspects, such as the behavior in the presence of some effectors, and the optimum pH. Umprimed and primed activities presented two pHs optima, both sharing only one. The proteoglucans synthesized under the different pHs gave different patterns after analysis under denaturing PAGE and the oligosaccharides synthesized on the protein backbone differ in the glucosyl length. It is concluded that also in rat brain, the initiation process of glycogen biosynthesis is mediated through the formation of a glycoprotein. Our present results showed that the step of the putative "Glycogen Initiator" proposed by use before, requires two enzymes UDPGlc-transglucosylating activities, Glycogen Initiator 1 and Glycogen Initiator 2, before Glycogen Synthase in the alpha-1,4-glucosidic linkages formation.
Thermal Stability of Self-Assembled Monolayers:  Influence of Lateral Hydrogen Bonding (2002)

Temperature-programmed desorption (TPD) of self-assembled monolayers (SAMs) on gold is investigated by using in parallel mass spectrometry (MS) and infrared reflection−absorption spectroscopy (IRAS). Monolayers formed by HS(CH2)n−OH (n = 18, 22) and HS(CH2)15−CONH−(CH2CH2O)−H (EG1) are compared to reveal the influence of specifically introduced hydrogen-bonding groups on their thermal stability. The overall desorption process of the above molecules is found to occur in two main steps; a disordering of the alkyl chains followed by a complex series of decomposition/desorption reactions. The final step of the process involves desorption of sulfur from different chemisorption states. The amide-group-containing SAM, which is stabilized by lateral hydrogen bonds, displays a substantial delay of the alkyl chain disordering by about 50 K, as compared to the linear chain alcohols HS(CH2)n−OH. Moreover, the decomposition of the alkyls and the onset of sulfur desorption occur at a temperature that is higher by approximately 25 K as compared to the HS(CH2)18−OH SAM. The desorption process is also studied for two oligo(ethylene glycol)-terminated SAMs, HS(CH2)15−X−(CH2CH2O)4−H (EG4-SAMs), where X is −CONH− and −COO− linking groups. In addition to the molecular chain disordering, the decomposition/desorption process of the EG4-SAMs occurs in two steps. The first is associated with the loss of the oligomer portion and the second with the desorption of the alkylthiolate part of the molecule. Our study points out that lateral hydrogen bonding, introduced via amide groups, is a convenient way to improve the thermal stability of alkanthiolate SAMs.
A delay-range-dependent approach to robust H&#x221E; control for uncertain linear systems with time-varying delays (2009)

The problem of delay-range-dependent robust Hinfin control for uncertain systems with time-varying delays and parameter uncertainties is investigated in this paper. The time delay is assumed to be a time-varying continuous function belonging to a given range. By introducing some free weighting matrices and by exploiting a novel Lyapunov-Krasovskii functional, which includes the information of the range of the time delay, some new delay-range-dependent criteria on stability, stabilization and the existence of a Hinfin controller are proposed in terms of linear matrix inequality (LMI). These developed results enjoy less conservatism than some existing ones. Numerical examples are provided to demonstrate the effectiveness and the advantages of the proposed method.