gebhart/patrepeval huggingface dataset:
Treatment of Parainfluenza 3 infection With DAS181 in a Patient After Allogeneic Stem Cell Transplantation (2011)

Parainfluenza virus (PIV) infections are common after allogeneic SCT and can cause severe morbidity, yet there is no effective treatment. DAS181 is an investigational antiviral medication which is active in vitro and in vivo against PIV. It is a recombinant sialidase protein which removes sialic acid residues. Binding to these residues is the initial step in PIV infection. We report the first treatment of PIV3 infection with DAS181 in a SCT patient. A 63 year-old female with AML underwent a second SCT after primary graft failure. Conditioning included fludarabine and alemtuzumab, with tacrolimus as GVHD prophylaxis. After engraftment, her course was complicated by grade III skin GVHD which was treated with steroids and mycophenolate mofetil. Three months after her second SCT, she developed nasal congestion and cough and was found to have PIV3 infection. She was treated with bronchodilators and IVIG. There was no evidence of superinfection. She was admitted 6 weeks later for pancytopenia and worsening respiratory status thought to be from progressive PIV3 infection. Given her worsening status, we obtained an emergency IND from the FDA to administer DAS181. The patient was treated with a dose of 10 mg daily inhaled for 3 consecutive days. She tolerated the therapy well. Within one day of initiating treatment, the patient subjectively felt better. She did not require supplemental oxygen by day 3 of therapy and was discharged. Initial pulmonary function tests (PFTs) showed FEV1 of 0.76L and DLCO was 36% of predicted. Subsequent PFTs showed FEV1 of 0.91L and DLCO was 53% of predicted. Serial samples from nasal and oral sites were taken and showed reduction of PIV virus loads as measured by PCR.Table 1Parainfluenza viral load as measured by PCR from oral and nasal sitesDaySitePIV3 copies / ml1Oral1.47 E43Oral2.90 E31Nasal1.72 E73Nasal7.30 E4 Open table in a new tab In vitro testing of the infecting PIV strain showed an inhibitory dose between 10-100 nM. One week later, the patient's respiratory symptoms worsened. She was found to have evidence of persistent PIV3 infection as well as relapse of AML. Treatment was initiated with a second course of DAS181, but her AML progressed rapidly and she died from complications of AML. The cause of death was unrelated to PIV infection. Treatment with inhaled DAS181 clearly brought about a clinical improvement as evidenced by improved symptoms, PFTs, exam, and decrease in PIV virus load. Longer treatment may be required in SCT recipients. DAS181 administration for treatment of PIV infections should be systematically tested in patient groups at risk for severe disease.
Reaction of N,N'-Carbonyldiimidazole and N,N'-Thionyldiimidazole with Carbonyl Compounds: A New Imidazole Transfer Reaction (1980)

Although much attention has been paid to the urefulnes of the diimidazolider ruch as N,N'-carbonyldiimidazole
Radiocarbon—A Direct Calculation of the Period of the Grand Trend (1984)

A major collective effort was made to develop a data base for establishing the relationship between 14 C and calendric ages (Stuiver, 1982). The early “cosmic schwung” fit between the two ages (Suess, 1970a, p 310) and the 10,350 yr period of the grand trend (Suess, 1970b, p 596) have recently been replaced by the period of 12,100 yr (Suess, 1980). The period of the grand trend was estimated by correlating the data with an a priori postulated sine function (Suess, 1970, p 596), or more recently a polynomial fit of the sixth degree was used (Klein et al , 1982). In the detrended data, periods (wiggles) of between 2400 yr and 104 yr were identified by conventional time series analysis. This approach could not be used to estimate the period of the grand trend, because the time series includes less than one cycle, whereas several cycles are required in order to get a meaningful result.
The Future of Germany and Politik für Deutschland: Ein Dokumentation (1968)

Journal Article The Future of Germany and Politik für Deutschland: Ein Dokumentation Get access The Future of Germany. By Karl Jaspers. Trans. and ed. by E. B. Ashton. Foreword by Hannah Arendt. Chicago, London: University of Chicago Press. 1967 & 1968. 173 pp. $4.95. 45s.Politik für Deutschland: Ein Dokumentation. By Fritz Erler. Foreword by Willy Brandt. Ed. and compiled by Wolfgang Gaebler. Stuttgart: Seewald. 1968. 647 pp. Bibliog. Index. DM 28. David Childs David Childs Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 44, Issue 4, October 1968, Pages 793–794, https://doi.org/10.2307/2614974 Published: 01 October 1968
An IgG<sub>2a</sub>-producing variant of an IgG<sub>2b</sub>-producing mouse myeloma cell line. Structural studies on the Fc region of parent and variant heavy chains (1978)

The IgG2b-producing MPC 11 mouse myeloma cell line has yielded a number of variants which synthesize heavy chains characteristic of a different immunoglobulin subclass, IgG2a, as previously shown by serology, peptide maps, and assembly profiles. We have studied the Fc regions of the IgG2a protein synthesized by one variant, ICR 9.9.2.1, and of the IgG2b protein synthesized by MPC 11 and compared them to MOPC 173, an IgG2a protein of known sequence. We analyzed the Fc regions of the three immunoglobulins by several analytical techniques, such as immunoelectrophoresis of papain digests, NaDodSo4-polyacrylamide gel electrophoresis analyses of Fc CNBr fragments, and comparative ion-exchange chromatography of radiolabeled tryptic and chymotryptic Fc peptides. In addition, Fc CNBr fragments of the variant gamma2a and MPC 11 gamma2b molecules were isolated and subjected to amino acid analysis and partial sequence determination. From these data, we concluded that the Fc fragment of ICR 9.9.2.1 is most probably identical to that of MOPC 173 and different from the parental gamma2b Fc fragment. A number of residue positions which discriminate between gamma2b and gamma2a sequences are described. In two of three segments sequenced, gamma2b and gamma2a molecules share more identical residues than either shares with another mouse subclass, gamma1.
Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome (2007)

Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP), an mRNA binding protein that is hypothesized to regulate local mRNA translation in dendrites downstream of gp1 metabotropic glutamate receptors (mGluRs). However, specific FMRP-associated mRNAs that localize to dendrites in vivo and show altered mGluR-dependent translation at synapses of Fmr1 knock-out mice are unknown so far. Using fluorescence in situ hybridization, we discovered that GluR1/2 and postsynaptic density-95 (PSD-95) mRNAs are localized to dendrites of cortical and hippocampal neurons in vivo. Quantitative analyses of their dendritic mRNA levels in cultured neurons and synaptoneurosomes did not detect differences between wild-type and Fmr1 knock-out (KO) mice. In contrast, PSD-95, GluR1/2, and calcium/calmodulin-dependent kinase IIalpha (CaMKIIalpha) mRNA levels in actively translating polyribosomes were dysregulated in synaptoneurosomes from Fmr1 knock-out mice in response to mGluR activation. [35S]methionine incorporation into newly synthesized proteins similarly revealed impaired stimulus-induced protein synthesis of CaMKIIalpha and PSD-95 in synaptoneurosomes from Fmr1 KO mice. Quantitative analysis of mRNA levels in FMRP-specific immunoprecipitations from synaptoneurosomes demonstrated the association of FMRP with CaMKIIalpha, PSD-95, and GluR1/2 mRNAs. These findings suggest a novel mechanism whereby FMRP regulates the local synthesis AMPA receptor (AMPAR) subunits, PSD-95, and CaMKIIalpha downstream of mGluR-activation. Dysregulation of local translation of AMPAR and associated factors at synapses may impair control of the molecular composition of the postsynaptic density and consequently alter synaptic transmission, causing impairments of neuronal plasticity observed in Fmr1 knock-out mice and fragile X syndrome.
<b>Genetic identification of FIN2, a far red light‐specific signaling component of</b><i><b>Arabidopsis thaliana</b></i> (1998)

Phytochrome A (PhyA) mediates most, if not all, various plant responses to far-red (FR) light. Here, we report a novel genetic mutation that impairs a variety of responses in the PhyA-signaling pathway of Arabidopsis thaliana. The mutation was isolated by screening seedlings that show reduced sensitivity to continuous far-red (FRc) light irradiation, but not to continuous red (Rc) light irradiation. The mutation named fin2-1 is not allelic to a PHYA mutation. Furthermore, immunoblot analysis indicated that the amount of the phytochrome A apoprotein in the fin2-1 mutant was comparable to that in wild type. Seedling of the fin2-1 mutant showed defects in hypocotyl growth inhibition and apical hook and cotyledon opening in FRc light but not in Rc light. The results showed that the mutation occurred in a downstream signaling component potentially specific to PhyA. Other PhyA-mediated responses such as FR-preconditioned blocking of greening, anthocyanin accumulation, reduction of gravitropic response, and expression of the CAB and CHS genes were impaired by the fin2-1 mutation: the degree of the mutant effect on the responses was variable. However, FR light-mediated seed germination and photoperiodic flowering responses were not affected significantly in the mutant. These results showed that FIN2 defines an upstream branch point in the PhyA signaling pathway.
Prognostic effect of CD55<sup>SC-1</sup> in gastric carcinoma (GC) and survival after treatment with the monoclonal antibody SC-1 (2004)

4067 Background: SC-1 is a human monoclonal IgM antibody that targets CD55SC-1, a cell surface receptor specifically expressed on human GC cells, inducing apoptotic cell death and tumor cell regression in nude mice with no toxicity. The aim of this study was to examine whether CD55SC-1 expression is a prognostic tool in GC, and whether SC-1 confers a survival benefit in GC patients. Methods: Retrospective data from 126 CD55SC-1 positive and negative GC surgery-only patients from 1990–1997 was used to determine the prognostic ability of CD55SC-1. In an open-label, non-randomized study between 1997–2001, 51 CD55SC-1 positive GC patients received a single i.v. infusion of 10–30mg SC-1 24–48 hours before curative surgical (R0) resection. Data were compared to 19 CD55SC-1 negative GC patients who received only curative surgery between 1997–2001. Results: In the retrospective analysis, median survival of CD55SC-1 negative R0 patients was better than untreated CD55SC-1 positive R0 patients (93 months vs. 27 months); better UICC staging is associated with CD55SC-1 negative patients who are more associated with longer survival than CD55SC-1 positive patients (Cox proportional hazards, HR=2). In R0 resected patients after 1997, treatment with SC-1 increased survival at 2 years (77%) compared to CD55SC-1 negative untreated patients (63%). Conclusions: CD55SC-1 may be a prognostic factor in GC; an imbalance in UICC stage between CD55SC-1 positive and negative patients requires further data to confirm the prognostic ability of CD55SC-1, and may also indicate that CD55SC-1positive tumors are more aggressive. Treatment of CD55SC-1 positive GC patients with SC-1 increased 2-year survival compared to CD55SC-1 negative untreated patients. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration H3 Pharma, Inc.; OncoMab GmbH OncoMab GmbH OncoMab GmbH
Exploring PSI-MI XML Collections Using DescribeX (2007)

Summary PSI-MI has been endorsed by the protein informatics community as a standard XML data exchange format for protein-protein interaction datasets. While many public databases support the standard, there is a degree of heterogeneity in the way the proposed XML schema is interpreted and instantiated by different data providers. Analysis of schema instantiation in large collections of XML data is a challenging task that is unsupported by existing tools. In this study we use DescribeX, a novel visualization technique of (semi-)structured XML formats, to quantitatively and qualitatively analyze PSI-MI XML collections at the instance level with the goal of gaining insights about schema usage and to study specific questions such as: adequacy of controlled vocabularies, detection of common instance patterns, and evolution of different data collections. Our analysis shows DescribeX enhances understanding the instance-level structure of PSI-MI data sources and is a useful tool for standards designers, software developers, and PSI-MI data providers.
MicroRNA-223 Induced Repolarization of Peritoneal Macrophages Using CD44 Targeting Hyaluronic Acid Nanoparticles for Anti-Inflammatory Effects (2016)

The aim of this study was to evaluate macrophages repolarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype upon transfection with microRNA-223 (miR-223) duplexes and miR-223 expressing plasmid DNA encapsulated in CD44-targeting hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles (NPs). The HA-PEI/miR-223 NPs with spherical shape and an average diameter of 200 nm were efficiently internalized by J774A.1 alveolar and primary peritoneal macrophages and non-cytotoxic at HA-PEI concentration less than 200 μg/mL. Transfection of HA-PEI/miR-223 NPs in J774A.1 macrophages showed significantly higher miR-223 expression than that with HA-PEI/plasmid DNA expressing miR-223 (pDNA-miR-223). HA-PEI/miR-223 NPs mediated transfection increased miR-223 expression to 90 fold in primary peritoneal macrophages compared to untreated cells. The overexpression of miR-223 in both J774A.1 and peritoneal macrophages induced a phenotypic change from M1 to M2 state as indicated by a decrease in iNOS-2 (M1 marker) and an increase in Arg-1 (M2 marker) levels compared to those in lipopolysaccharide (LPS) and interferon-gamma (IFN-γ)-stimulated macrophages (M1). The change in macrophage phenotype by HA-PEI/miR-223 NPs could suppress the inflammation in peritoneal macrophages induced by LPS as evidenced by a significant decrease in pro-inflammatory cytokine levels TNF-α, IL-1β and IL-6, compared to LPS-stimulated peritoneal macrophages without treatment. The results demonstrated that miR-223-encapsulated HA-PEI NPs modulated macrophage polarity toward an anti-inflammatory M2 phenotype, which has potential for the treatment of inflammatory diseases.
The Common Chemical Motifs Within Anesthetic Binding Sites (2007)

Anesthetic binding to proteins involves amphipathic interactions.
ChemInform Abstract: GASTRIC ANTISECRETORY 9H‐XANTHEN‐9‐AMINES (1984)

Abstract Aus dem Acetat (I) und dem Amin (II) erhält man das Xanthenamin (III).
Fine-pitch high-efficiency spatial optical modulator for mobile display applications (2010)

Diffractive spatial optical modulators (SOM) employing a fine-pitch pixel array were introduced. The micromechanical designs of the lead zirconate titanate (PZT) actuator and mirror ribbon structure were optimized for a small volume while maintaining the same level of performance. The same design rule and fabrication equipment were used for a new 10-µm-pitch and conventional 16-µm-pitch SOM. The optical efficiency of the new SOM was 78% (zeroth-order diffraction), which is an improvement over that of the 16-µm-pitch SOM (73%). The full on/off contrast ratio showed no differences, and a high displacement of 500 nm was achieved. The stress of the Pt/PZT/Pt actuating layer was the main parameter affecting the initial gap height and displacement of the ribbon. The required ribbon flatness could be achieved by applying a stress gradient on the SiN layer. The temperature-sensitive characteristics, which degrade image quality, could be minimized by a mechanical compensation method that takes advantage of the thermal expansion effect of Si substrates. The estimated lifetime of the device is >4000 h. The developed fine-pitch SOM device has sufficient response time and ribbon displacement to be suitable for high-quality embedded laser-projection displays. The VGA optical module was successfully demonstrated in a mobile laser projection display.
Evaluation of New Ultrasound Technologies Should Include Assessments of Peripheral Nerve Function (2011)

I am writing in reference to the articles by Gadsden et al1 and Jewell et al2 in the May issue of Aesthetic Surgery Journal regarding focused ultrasound.

The authors of those studies very carefully measured a variety of physiologic and chemical components and reported that the high-intensity focused ultrasound (HIFU) …
THE BORON-CARBON SYSTEM. Quarterly Report No. 2 for August 1, 1960 - October 31, 1960 (1960)

A definitive investigation of the boron-carbon equilibrium system is being made by x-ray-diffraction, metallographic, and thermal analytical techniques. Additional boron-- carbon alloys were prepared by sirtering and arc- melting compacts prepared from boron and high-purity graphite. Metallographic examinations of these alloys are in agreement with alloys previously prepared from lampblack. X-ray investigation of sintered compacts indicates that the solubility range of boron carbide extends almost to pure boron. Boron of various purities was annealed for times up to 4 hr, but no structure other than beta - rhombehedral has been detected. Very high purity boron (10 ppm impurity) was obtained for the study of allotropy and the equilibrium relationships at very dilute carbon contents. (For preceding period see ARF-2200-3.) (auth)
Hot compression deformation behaviors of as-extruded AZ81 magnesium alloy at elevated temperature (2011)

The hot compression tests of AZ81 magnesium alloy were performed on Gleeble-1500 at deformation temperature of 320-440 ℃ and strain rate of 0.01-10 s-1.The results show that the relationship between stress and strain is affected obviously by the strain rate and deformation temperature.The flow stress becomes higher with increasing strain rate at constant temperature and lower with increasing deformation temperature at constant strain rate.In order to evaluate the hot-pressing process,a flow stress model was constituted based on Arrhenius equation and temperature-compensated strain rate factor,the Zener-Hollomon parameter,and modified further by considering the effect of strain on stress.The results show that the modified model agrees well with the experimental stress value under the experimental condition what offer a experimental theoretical basis for close-pressing net-shape.
The Natura 2000 Biogeographical Process (2015)

describes both the current participation and the future plans.
Non‐psychoactive CB <sub>2</sub> cannabinoid agonists stimulate neural progenitor proliferation (2006)

Cannabinoids, the active components of marijuana and their endogenous counterparts, act on the brain and many other organs through the widely expressed CB1 cannabinoid receptor. In contrast, the CB2 cannabinoid receptor is abundant in the immune system and shows a restricted expression pattern in brain cells. CB2-selective agonists are, therefore, very attractive therapeutic agents as they do not cause CB1-mediated psychoactive effects. CB2 receptor expression in brain has been partially examined in differentiated cells, while its presence and function in neural progenitor cells remain unknown. Here we show that the CB2 receptor is expressed, both in vitro and in vivo, in neural progenitors from late embryonic stages to adult brain. Selective pharmacological activation of the CB2 receptor in vitro promotes neural progenitor cell proliferation and neurosphere generation, an action that is impaired in CB2-deficient cells. Accordingly, in vivo experiments evidence that hippocampal progenitor proliferation is increased by administration of the CB2-selective agonist HU-308. Moreover, impaired progenitor proliferation was observed in CB2-deficient mice both in normal conditions and on kainate-induced excitotoxicity. These findings provide a novel physiological role for the CB2 cannabinoid receptor and open a novel therapeutic avenue for manipulating neural progenitor cell fate.
Formation and migration of hydride ions in BaTiO<sub>3−x</sub>H<sub>x</sub> oxyhydride (2016)

The formation, stability and migration of hydride ions in BaTiO<sub>3−x</sub>H<sub>x</sub> oxyhydride are revealed by first principle calculations.
Postsurgical Cataract Prophylaxis With Intravitreal “Triamcinolone-Moxifloxacin” May Not Be Optimal For Preventing Endophthalmitis (2018)

Intravitreal monotherapy with TM did not provide consistent prevention of SA endophthalmitis, whereas intravitreal TMV successfully prevented endophthalmitis because of SA with elevated MIC values to moxifloxacin. Cataract surgeons need to be aware that vancomycin seems to be essential for intravitreal prophylaxis to cover moxifloxacin resistance.
Mirrors (2004)

We identify three design principles for reflection and metaprogramming facilities in object oriented programming languages. <i>Encapsulation</i>: meta-level facilities must encapsulate their implementation. <i>Stratification</i>: meta-level facilities must be separated from base-level functionality. <i>Ontological correspondence</i>: the ontology of meta-level facilities should correspond to the ontology of the language they manipulate. Traditional/mainstream reflective architectures do not follow these precepts. In contrast, reflective APIs built around the concept of <i>mirrors</i> are characterized by adherence to these three principles. Consequently, mirror-based architectures have significant advantages with respect to distribution, deployment and general purpose metaprogramming.
Proposal of Hot-pressed, Rod-shaped Tungsten Armor Concept for ITER Divertor and its High-heat-flux Performances (2005)

This paper describes the R&D of plasma facing components, especially the joining technology of the tungsten/copper joint for the ITER divertor application. The major concern for this joint is detachment due to the large differences in the thermal expansion coefficient and the modulus of elasticity of each metal. One solution is to separate the joint area into small pieces to reduce interfacial stress at the joint. From this viewpoint, JAERI proposes the hot-press method using small tungsten rods pressed into cylindrical bores in the copper substrate at high temperature. A divertor mock-up was fabricated to investigate the durability of this joint. No failures of the mock-up occurred in a thermal cycle experiment involving 3,000 cycles of 5 MW/m2 heat flux. Using numerical analyses, the contact heat transfer coefficient between the tungsten and copper was determined to be 2,400 W/m2/K for this mock-up. Though this value is slightly inadequate to maintain the surface temperature below the recrystallization temperature of tungsten, it is significant that no embrittlement failures of the rod-shaped armor were observed. Further R&D is suggested to improve the hot-press method, including surface treatment of the rod faces or the use of insert material.