gebhart/patrepeval huggingface dataset:
Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection (1996)

Murine cytomegalovirus (MCMV) infection of mice induces early cytokines. Although certain of these can directly inhibit viral replication, they also can promote defense by activating NK cells. MCMV induces IFN-alphabeta-dependent NK cell cytotoxicity and IL-12-dependent NK cell IFN-gamma production. Studies were initiated to define cytokine-mediated NK and T cell-independent antiviral defense and specific cytokine-elicited NK cell responses during MCMV infections. IFN-alphabeta, TNF, IL-12, and IFN-gamma were all shown to be induced 2 days after infection of immunocompetent mice. Infections of NK and T cell-deficient mice demonstrated that virus-induced IFN-alphabeta, TNF, and IL-12, but not IFN-gamma, were produced independently of these populations, and that IL-12 production occurred in the absence of detectable IFN-gamma. In vivo neutralization studies of IFN-alphabeta, TNF, and IL-12 showed that each of these factors had NK and T cell-independent antiviral functions, as well as specific effects on NK cell responses. Examination of NK cell cytotoxicity, blastogenesis, and IFN-gamma production demonstrated that: IL-12 was required for NK cell IFN-gamma production but not blastogenesis and cytotoxicity; IFN-alphabeta was necessary for NK cell blastogenesis and cytotoxicity but not IFN-gamma production; and TNF facilitated IFN-gamma production but inhibited NK cell cytotoxicity. This work defines the biologic consequences of early cytokine expression during viral infection.
U.S. Organizations' Personnel Management in Mexico (2002)

Abstract U.S. organizations are experiencing dramatic growth from the North American Free Trade Agreement. Companies that operate across the Mexican border must decide to either relocate currently employed personnel or to hire foreign nationals to staff positions. Since many cultural differences exist between the United States and Mexico, the use of “culture-pins,” or bicultural people who bridge value differences, may facilitate success in these operations. Consequently, this paper proposes that U.S. firms located in Mexico should recruit and retain Mexican Americans. RESUMEN Las corporaciones mexicanas y estadounidenses están creciendo dramáticamente como resultado directo del NAFTA. Las empresas que operan del otro lado de estas fronteras, debe decidir si desean trasladar a sus gerentes y trabajadores o contratar nacionales extranjeros para ocupar estos cargos. Este documento presupone que los iucomodines-culturalesl., o personas biculturales que pueden cruzar el puente de las diferencias culturales, son necesarios para asegurar el éxito de NAFTA y contribuir, brindando una inventaja competitivalc a las compañías participantes. La propuesta de este artículo es que las empresas estadounidenses que operan dentro de México se beneficiarían reclutando y entrenando mexicanos-norteamericanos para aumentar su fuerza de trabajo local. RESUMO As empresas mexicanas e americanas têm experimentado um crescimento diretamente relacionado à NAFTA. As empresas, que operam dentro destas fronteiras, devem decidir entre realocar os gerentes atuais contratados ou contratar estrangeiros para ocupar cargos disponíveis. Pretende-se, através deste estudo, mostrar que pessoas com ambas as culturas, capazes de superar as diferenças culturais, são essenciais para o sucesso da NAFTA e contribuem para a vantagem competitiva das empresas envolvidas. Este trabalho prop[otilde]e que as firmas americanas, atuando no México, seriam beneficiadas, se recrutassem e treinassem americanos, de origem mexicana, para aumentar a sua força de trabalho no México.
Congestion Control Based on Priority Drop for H.264/SVC (2007)

For H.264/SVC, different layers or frames have different order of precedence according to their importance on video quality and the decoding process. Network should provide more protection for high priority layers or frames when SVC flow is transmitted over IP network. This paper proposes an active queue management algorithm based on priority dropping and PID algorithm, called PIDPD, which first drops the least important packets when network congestion arises. PIDPD implements differentiated service in IP layer to provide high quality video for end user. In addition, PIDPD do not create a side effect for the performance of control system. Simulation shows this method can protect important video data well, lower the disturbance of background flow, and decrease the packet loss rate of SVC flow.
Animal and Clinical Pharmacologic Techniques in Drug Evaluation (1965)

Associate Professor of Medicine, Head, Section of Clinical Pharmacology, Hahne-mann Medical College and Hospital, Philadelphia, Assistant Professor of Medicine, Assistant Head, Section of Clinical Pharmacology, Hahnemann Medical College and Hospital, Philadelphia. Cloth. $18. Pp. 660, with 108 figures and 67 tables. Year Book Medical Publishers, Inc., Chicago, 1964.
Human cytomegalovirus genomics and transcriptomics through the lens of next-generation sequencing: revision and future challenges (2019)

The human cytomegalovirus (HCMV) genome was sequenced by hierarchical shotgun almost 30 years ago. Over these years, low and high passaged strains have been sequenced, improving, albeit still far from complete, the understanding of the coding potential, expression dynamics and diversity of wild-type HCMV strains. Next-generation sequencing (NGS) platforms have enabled a huge advancement, facilitating the comparison of differentially passaged strains, challenging diagnostics and research based on a single or reduced gene set genotyping. In addition, it allowed to link genetic features to different viral phenotypes as for example, correlating large genomic re-arrangements to viral attenuation or different mutations to antiviral resistance and cell tropism. NGS platforms provided the first high-resolution experiments to HCMV dynamics, allowing the study of intra-host viral population structures and the description of rare transcriptional events. Long-read sequencing has recently become available, helping to identify new genomic re-arrangements, partially accounting for the genetic variability displayed in clinical isolates, as well as, in changing the understanding of the HCMV transcriptome. Better knowledge of the transcriptome resulted in a vast number of new splicing events and alternative transcripts, although most of them still need additional validation. This review summarizes the sequencing efforts reached so far, discussing its approaches and providing a revision and new nuances on HCMV sequence variability in the sequencing field.
Review of Gas Test Technology of Hydrazine Rocket Propellant (2007)

Introduce the research gas test technology and its applications of hydrazine propellant both at home and abroad.
The influence of graded levels of atmospheric ammonia on chickens (1966)

Synopsis Experiments have been carried out to study the influence of high concentrations of ammonia on the performance of chickens. One hundred parts per million by volume of ammonia caused reductions in the respiration rate of adult hens of between 7 and 24 per cent. Carbon dioxide production and respiratory depth were also reduced. Broiler chickens reared in atmospheres containing high concentrations of ammonia from 28 days of age tended to eat less food than broilers reared in ammonia‐free atmospheres and at 100 p.p.m. of ammonia their growth rate was significantly reduced. Replacement laying pullets reared in atmospheres containing ammonia from 11 to 18 weeks of age, ate less food than similar birds reared in ammonia‐free atmospheres. When the ammonia level was 78 p.p.m. by volume, food consumption was significantly reduced in the period from 15 to 30 weeks of age. This lowered food intake was associated with significantly less live‐weight gain up to 22 weeks of age, and pullets reared in atmospheres with high ammonia concentrations matured up to 2 weeks later than pullets reared in ammonia‐free atmospheres.
Outcomes of pneumonectomy for N2 non small cell lung cancer (2019)

<b>Objective:</b> Our study aims at assessing the relevance of pneumonectomy for N2 disease according to disease free and overall survival. <b>Methods:</b> We restrospectively recorded all pneumonectomies performed in our centre for NSCLC from January 1st,1999 to December 31st, 2015. Definitive N2 stage on the final pathologic examination of lymph node dissection made the study group. Overall survival and disease free survival were studied. <b>Results:</b> Among 601 pneumonectomies, 209 patients had a stage N2 NSCLC. Neo-adjuvant chemotherapy was given in 63 (30,1%) patients. Adjuvant therapy was given in 150 (71.8%) patients. Only 40 (19.1%) patients underwent surgery alone. N2 invasion was a N2 unisite in 134 (64,1%) patients, and a skip N2 in 19 (9,1%) patients. Resection was microscopically uncomplete (R1) in 70 (33.5%) patients. The mortality rate was 5,3% (n=11) at 30 days and 12,4% (n=26) at 90 days. Overall survival was 58,4%, 26,3%, and 13.9% at 1, 3, and 5 years respectively. Independent risk factors for mortality were smoking over 20 PY, and a multisite N2 involvement. Adjuvant therapy was a protective factor. Disease free survival was 39,7%, 16,8%, and 11.5% at 1, 3, and 5 years respectively. Overall rate of recurrence was 53,1%. Independent risks factors for recurrence were microinvasion on pathologic findings, adenocarcinoma, and age over 70 years at the time of surgery. <b>Conclusions:</b> In experienced hands, pneumonectomy should be offered to patients despite risk of N2 disease provided N2 involvement is limited to unisite or skip N2 disease. Multimodality treatment including surgery should be offered to provide a fair overall and disease free survival.
New Approach to Treatment of Shock???Restitution of Vasoreactivity (2002)

Our objective was to observe the therapeutic effect of restituting vasoreactivity agent in severe shock. A hemorrhagic shock (HS) model was reproduced in rat and the response of arterioles of spinotrapezius muscle to norepinephrine (NE) in HS was tested. The diameter, blood velocity, and volumetric flow in arteriole, and the mean arterial pressure (MAP) were measured. The therapeutic effect was observed after the treatment of restituting vasoreactivity agent (glybenclamide--an inhibitor of ATP sensitive potassium channel, and tiron--an oxygen free radical scavenger). The arteriolar vasoreactivity was significantly reduced with 15 fold increase of NE threshold 2 h post HS. After treated with restituting agent (RA), the vascular hyporeactivity of rat was apparently recovered, and the increased level of MAP following injection of dopamine was 1.8 times and 1.9 times more than that in NS-treated and DMSO-treated group respectively. After reinfusion of shed blood, the value of systemic blood pressure maintained more than 100 mmHg and volumetric flow in arterioles in RA group were 2 times more than those in NS treated group within the 2 h observation periods. The average survival time in RA treated group was also 1.8 times and 1.6 times longer than that in NS-treated and DMSO-treated group respectively. The restituting vasoreactivity agent is able to recover the lower vasoreactivity with excellent anti-shock effect in severe hemorrhagic shock.
Modelling smartphone usage (2016)

We develop a Markov state transition model of smartphone screen use. We collected use traces from real-world users during a 3-month naturalistic deployment via an app-store. These traces were used to develop an analytical model which can be used to probabilistically model or predict, at runtime, how a user interacts with their mobile phone, and for how long. Unlike classification-driven machine learning approaches, our analytical model can be interrogated under unlimited conditions, making it suitable for a wide range of applications including more realistic automated testing and improving operating system management of resources.
On Its Way to K–12 Classrooms, Web 2.0 Goes to Graduate School (2008)

ABSTRACT As corporate and higher education settings increasingly use Web 2.0 tools, the time has come to think about preparing K–12 in-service teachers to find ways in which these tools might support classroom teaching and learning goals. This article describes a graduate course designed and taught in spring 2007. Using a modeling and situated learning framework, the article discusses Web 2.0 tools, K–12 education, and the course design. It also presents a summary of course participants’ survey responses concerning their perceptions of their learning experience. Survey responses demonstrated that teacher-learners appreciated and endorsed the design of the course and felt their learning experiences scaffolded their ability to use Web 2.0 tools in their classroom and school context. The article concludes with several design recommendations and examples of classroom applications.
A graphical user interface of blood flow through a multi irregular of stenosed artery (2015)

A mathematical model of blood flow through a multi-irregular stenosed arlery is developed and visualized using the Graphical User Interface (GUI) in MATLAB. The flow of blood is assumed to be two-dimensional, unsteady, laminar, incompressible and axisymmetric. The streaming blood has been considered to be a Newtonian blood flow. The goveming equations of motion accompanjed by an appropriate boundary conditions are solved numerically using MAC (Marker and Cell) method in cylindrical coordinate system in staggered grids. The pressure-Poisson equation was then solved by using the successive-over-relaxation (SOR) method. The pressure drop gives higher values and the separation region is found to be larger in the case of blood flowing through a flexible artery having multiple irregular stenosis when compared to blood flowing through a single irregular stenosed artery. The numerical results of the blood flow characteristics such as axial and radial velocities. flow rate and wall shear stress under the influence of multiple stenosis is then visualized using GUI. The results show that, the flow rate and wall shear stress have lower values compared to the velocity profiles which has the higher values with iower Reynolds number and vice versa.
Treatment of neuroblastoma with [125I]metaiodobenzylguanidine. (1992)

To find a treatment that may be effective against micrometastases of advanced, stage III or IV neuroblastoma, [125I]metaiodobenzylguanidine (125I-MIBG) was used in a phase I toxicity trial. In seven patients, thrombocytopenia was encountered with absorbed whole body doses of 85-135 rad from 125I-MIBG, but the dosimetry was imprecise in predicting bone marrow injury. Three patients survived for over one year, results that may indicate efficacy of 125I-MIBG therapy.
Reoccurrence of the White Fronted Shearwater (Procellaria Leucomelaena Temminck) in Indo ceylonese Waters (1967)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
<i>Equations of Mathematical Physics</i> (1964)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation A. N. Tikhonov, A. A. Samarskii, A. R. M. Robson, P. Basu, D. M. Brink, J. Gillis; Equations of Mathematical Physics. Physics Today 1 September 1964; 17 (9): 80. https://doi.org/10.1063/1.3051872 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
Ethical and legal implications of treating casualty wild animals (2006)

THE care of wildlife presents many veterinary challenges and dilemmas. The animals are, by definition, ‘wild’ and as such have no owner. Diagnosis and treatment can be time‐consuming, frustrating and expensive. Care of wild animals is complicated by their being particularly susceptible to stressors and other adverse effects of close contact with humans and confinement in captivity. Despite great advances in wildlife, zoo and exotic animal medicine in recent years, relatively little information is available about the biology, let alone the veterinary care, of the majority of wild species that may be presented for examination and treatment. These difficulties are compounded by the fact that in the UK, and many other countries, wildlife species are protected under national legislation and other statutes may apply to some of them. Veterinary surgeons who are involved in treating casualty wild animals must, therefore, be aware of the relevant legislation and abide by it. They also need to be able to advise clients appropriately. In addition to the practicalities and legal considerations of wildlife care outlined above, there are numerous ethical dilemmas confronting those who involve themselves in such work. These are often complex and the solutions are usually not clear cut. This article discusses ethical and legal aspects of treating casualty wild animals, with particular reference to the situation, as it stands, in the UK, but drawing, where appropriate, on the authors’ own experience and relevant information from elsewhere.
Imaging Through Turbulence (1995)

Introduction Overview of the Problem Area Historical Overview of Imaging Through Turbulence Overview of the Book Background: Fourier and Statistical Optics Fourier Optics Statistical Optics Turbulence Effects on Imaging Systems Index of Refraction Fluctuations in the Atmosphere Statistics of Index of Refraction Fluctuations Wave Propagation through Random Media First-Order Turbulence Effects on Incoherent Imaging Modal Expansions of Phase Perturbation Phase Screen Generation Speckle Imaging Techniques Introduction Overview of Speckle Imaging Speckle Interferometry Fourier Phase Estimation Techniques Image Reconstruction for Speckle Imaging Conclusion Adaptive Optical Imaging Systems Introduction Factors that Degrade AOI Systems Performance Adaptive Optical System Components and Models AOI System Performance Modeling Summary Hybrid Imaging Techniques Introduction Deconvolution from Wavefront Sensing Methods Involving Adaptive Optics Conclusion Index
Vacuum Output Gas Chromatography. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVacuum Output Gas Chromatography.P. F. Varadi and Kitty. EttreCite this: Anal. Chem. 1963, 35, 3, 410–412Publication Date (Print):March 1, 1963Publication History Published online1 May 2002Published inissue 1 March 1963https://pubs.acs.org/doi/10.1021/ac60196a045https://doi.org/10.1021/ac60196a045research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Productivity enhancement of stepped solar still: Performance analysis (2008)

Maintaining minimum depth in conventional basin type solar still is difficult, as the area is large. However this can be achieved in stepped solar still in which the area of the basin is minimized by having small trays. Very few works have been carried so far in stepped solar still and constant depth trays are used in the basin plate. In this work, a stepped still with two different depth of trays are used. The basin plate contains twenty five trays with 10 mm depth and twenty five trays with 5 mm depth. To improve the productivity, experiments were carried out by integrating small fins in basin plate and adding sponges in the trays. Theoretical and experimental analyses are made for fin type, sponge type, and combination of fin and sponge type stepped solar still. When the fin and sponge type stepped solar is used, the average daily water production has been found to be 80% higher than ordinary single basin solar still. The theoretical results agree well with the experimental. Also an economic analysis was made. The payback period of this setup is 400 days.
Minimal Proteinuria One Year after Transplant is a Risk Factor for Graft Survival in Kidney Transplantation (2009)

It is generally accepted that one-year post-transplant proteinuria over 0.5 gm per day has a negative impact on renal graft survival. In this study, the effects of minimal proteinuria less than 0.5 g/day were analyzed in 272 renal recipients who had survived for one year with a functioning graft. Recipients were classified by one-year post-transplant proteinuria: no proteinuria group (<0.2 g/day), minimal proteinuria group (0.2-0.5 g/day), and overt proteinuria group (>or=0.5 g/day). Recipients were followed up for 87.1+/-21 months after transplantation and 38 (13.9%) lost their graft during follow-up. Fifteen percent of patients had minimal proteinuria and 7.8% had overt proteinuria. Five-year graft survival in the minimal proteinuria group was 83.0%, and that in the overt proteinuria group was 70%, in contrast to 97.1% in the no proteinuria group (p=0.01 for trend). In a multivariate analysis, the minimal proteinuria group (relative risk [RR], 4.90; 95% confidence interval [CI], 2.09-11.46) and the overt proteinuria group (RR, 8.75; 95% CI, 3.29-23.29) had higher risks of graft failure than the no proteinuria group. Even minimal proteinuria at one year after transplantation was strongly associated with poor graft outcome. Therefore, it appears logical to consider a low level of proteinuria as a risk factor for graft survival in renal recipients.
Human DNA Polymerase β Deoxyribose Phosphate Lyase (1998)

DNA polymerase beta (beta-pol) cleaves the sugar-phosphate bond 3' to an intact apurinic/apyrimidinic (AP) site (i.e. AP lyase activity). The same bond is cleaved even if the AP site has been previously 5'-incised by AP endonuclease, resulting in a 5' 2-deoxyribose 5-phosphate (i.e. dRP lyase activity). We characterized these lyase reactions by steady-state kinetics with the amino-terminal 8-kDa domain of beta-pol and with the entire 39-kDa polymerase. Steady-state kinetic analyses show that the Michaelis constants for both the dRP and AP lyase activities of beta-pol are similar. However, kcat is approximately 200-fold lower for the AP lyase activity on an intact AP site than for an AP endonuclease-preincised site. The 8-kDa domain was also less efficient with an intact AP site than on a preincised site. The full-length enzyme and the 8-kDa domain efficiently remove the 5' dRP from a preincised AP site in the absence of Mg2+, and the pH profiles of beta-pol and 8-kDa domain dRP lyase catalytic efficiency exhibit a broad alkaline pH optimum. An inhibitory effect of pyridoxal 5'-phosphate on the dRP lyase activity is consistent with involvement of a primary amine (Lys72) as the Schiff base nucleophile during lyase chemistry.
The charging of small particles for electrostatic precipitation (1957)

CHARGING CONDITIONS and particle size are important factors in electrostatic gas cleaning. Particle mobility, the rate at which the particle moves in an electric field of unit strength, is a function of the charge and size of the particle. The minimum mobility and the particle size at which it occurs, are functions of the charging conditions.