gebhart/patrepeval huggingface dataset:
144 (2015)

Learning Objectives: Current scoring systems for use in critical illness do not\ntake into account levels of simultaneous physiological or pharmacological support.\nYet, clinicians at the bedside subconsciously interpret cardiovascular parameters\nin the context of this support. In the acquisition of subconscious expertise\nit is established that it is better to observe an expert solve a problem in real time\nthan to ask them to describe what they do in the abstract. Hypothesis: Using\nknowledge capture techniques it is possible to design a scale of the overall state\nof a critically ill patient underpinned by a sophisticated physiological rule base.\nMethods: Data sets were prepared from the Electronic Records of 10 patients\nwith 2761 time points of routinely collected physiological and pharmacological\nparameters. A clinician scored each time point as stable (A) through to unstable\n(E) whilst simultaneously describing a rule set of ranges (A-E) of derangement\nfor each parameter. The same time points were annotated automatically using\nthe rule set described in the abstract and inconsistencies between the two sets of\nannotations compared in a confusion matrix. Each disagreement was analyzed\nand changes made to the rule base where appropriate to better capture clinical\nexpertise. The process was repeated with two other clinicians, their clinical annotations\nbeing tested against the previous clinician’s rule set, resulting in further\nrefinements. Results: Agreement between clinician 1’s final rule set and annotations\npost refinement was 96.7%. Agreement between clinician 1’s final rule set\nclinician 2’s initial annotations and was 10.7% (97.6% after refinement). Initial\nagreement between clinician 2’s final rule set and clinician 3’s initial annotations\nwas 90.6% (98.1% after refinement - the final A to E rule set for the new\nscore).Conclusions: There was a higher agreement between the final rule set of\nthe first clinician and the initial annotations of each subsequent clinician as the\nrefinement proceeded. It is possible to design a sophisticated rule base underpinning\na physiological score using knowledge capture techniques.
Réanimation does not forget the foundations (2014)

L’analyse physiopathologique des situations de detresse vitale et des effets des interventions therapeutiques a ete et reste encore l’objet d’une recherche clinique intense et souvent passionnante. Cette approche, appliquee au quotidien dans le soin, a, pour beaucoup d’entre nous, joue un role determinant dans la decision d’exercer le metier de reanimateur. Dans une remise en cause argumentee de l’hegemonie de l’evidence-based medicine, trois editorialistes de renom plaidaient pour que l’on n’oublie pas les fondements de la pratique medicale en general et de la reanimation en particulier que constituent la bonne connaissance de la physiologie et la comprehension de la physiopathologie [1]. Pour illustrer leurs propos, les auteurs rappelaient que David Ashbaugh et Tom Petty ont invente le syndrome de detresse respiratoire aigue (SDRA) en proposant une physiopathologie commune a la detresse respiratoire presentee par 12 patients atteints d’affections tres diverses [2], ou encore que Paul Pepe et John Marini ont invente la pression positive de fin d’expiration (PEEP) intrinseque et decrit la physiopathologie de l’hyperinflation dynamique a partir de trois observations cliniques [3]. Ces deux exemples illustrent a mon sens parfaitement que, contrairement a ce que certains voudraient faire croire, le calcul de l’effectif necessaire et la randomisation ne sont pas des prealables indispensables a toute recherche clinique pertinente et utile. La decision du comite editorial de consacrer un numero entier de Reanimation a des articles de physiologie et/ou de physiopathologie me semble etre parfaitement conforme a cette vision. Rompant avec la logique habituelle de regroupement thematique, ce numero de la revue est constitue d’articles abordant des sujets tres divers. Ces articles ont en commun d’apporter une synthese actualisee des connaissances sur des mecanismes physiologiques ou physiopathologiques dont la comprehension est utile au medecin reanimateur, soit parce qu’ils expliquent les symptomes observes, soit parce qu’ils justifient l’approche therapeutique. Le lecteur ne retrouvera dans ce numero, j’en ai peur, ni forest plot ni cotation du « niveau de preuve ». Je suis convaincu qu’il saura s’en passer, preferant s’impregner des concepts et analyses proposes.
Chemically Fabricated Magnetic Quantum Dots of InP:Mn (2005)

Quantum dots of InP:Mn are chemically prepared by following hot colloidal nanochemistry with starting precursors that obviate the need for external surfactant. These quantum dots are uniform spheres with 3-nm diameters; they are crystalline, photoluminescent, and magnetic. The crystallographic and optical properties are similar to those of undoped InP nanocrystallites, while the magnetism is consistent with the ferromagnetic response observed in a class of diluted magnetic semiconductors. Because of the ultrafine sizes, the sample shows superparamagnetic behavior, whereas ferromagnetic hysteresis loops are clearly seen below the blocking temperature. Structural characterization and analysis confirm that the magnetism in these quantum dots is not due to segregated binary MnP or MnO phases and that they truly represent a homogeneous dilute magnetic semiconductor.
Case 17-1964 (1964)

Presentation of Case* First admission. A five-year-old white boy was admitted to the hospital because of abdominal pain.The child had been well until three months previously, when he began to experience recurrent episodes of dull, generalized pain in the abdomen. Three weeks before entry he was admitted to another hospital because of a sharp, crampy pain in the right groin. An exploratory operation revealed an undescended right testicle associated with a hernial sac containing blood; organizing hematomas within the omentum and the gastrocolic ligament and a "phlegmon" involving the pancreas were found. The amylase level was normal. The patient . . .
<title>Bacterial paleontology for astrobiology</title> (2002)

We review the development of Bacterial Paleontology and consider its relevance of the rapidly emerging field of Astrobiology. We present electron microscopic images of fossil bacteria in different states of preservation in Earth rocks and Astromaterials.
Thermomechanical model of the occurrence of oscillations in metal cutting (2012)

A model of excitation of self-vibrations, or oscillations, in metal cutting is considered in this work, wherein the loss of stability of the constant-speed cutting mode occurs as a result of temperature-dependent mechanical characteristics of the workpiece changing under the effect of heat generation in the cutting zone.
Effect of urine on clonal growth of human bladder cancer cell lines. (1991)

Human urine contains growth factors; their physiological roles have not been established. The effect of normal human urine was examined in vitro on clonal growth of human bladder cancer cell lines. Clonal growth of HT-1376, HT-1197, and T24 was enhanced by five different fresh human urine samples from young men. Colony stimulating activity was detected in fractions with a molecular weight greater than 5000 by ultrafiltration. Sephadex G-50 gel chromatography identified two peaks of colony stimulative activity in HT-1376 with molecular weights of approximately 6000 and greater than 12,400, respectively; these two peaks also possessed immunoreactive epidermal growth factor (EGF) and NRK-49F transforming activities. The three bladder cancer cell lines possessed large quantities of EGF specific binding sites and exogenous EGF stimulated colony formation; EGF concentrations in human urine were found to be remarkably higher than those of exogenously added EGF which stimulated clonal growth of bladder cancer cell lines. Moreover, it was demonstrated that fresh urine samples (5%) incubated with anti-human EGF monoclonal antibody (KEM-10) neutralized completely the colony stimulating effects in HT-1376. These results indicate that fresh human urine stimulates clonal growth in human bladder cancer cell lines and that a major part of the activity is represented by urinary EGF. The data promote urinary EGF as a progressive agent of human bladder cancer.
On-Device User Intent Prediction for Context and Sequence Aware Recommendation (2019)

The pursuit of improved accuracy in recommender systems has led to the incorporation of user context. Context-aware recommender systems typically handle large amounts of data which must be uploaded and stored on the cloud, putting the user's personal information at risk. While there have been previous studies on privacy-sensitive and context-aware recommender systems, there has not been a full-fledged system deployed in an isolated mobile environment. We propose a secure and efficient on-device mechanism to predict a user's next intention. The knowledge of the user's real-time intention can help recommender systems to provide more relevant recommendations at the right moment. Our proposed algorithm is both context and sequence aware. We embed user intentions as weighted nodes in an n-dimensional vector space where each dimension represents a specific user context factor. Through a neighborhood searching method followed by a sequence matching algorithm, we search for the most relevant node to make the prediction. An evaluation of our methodology was done on a diverse real-world dataset where it was able to address practical scenarios like behavior drifts and sequential patterns efficiently and robustly. Our system also outperformed most of the state-of-the-art methods when evaluated for a similar problem domain on standard datasets.
Evaluation of Oxygen‐Related Carrier Recombination Centers in High‐Purity Czochralski‐Grown Si Crystals by the Bulk Lifetime Measurements (1995)

Present day high‐purity Czochralski(CZ)‐grown Si crystals are characterized by the bulk carrier recombination life‐time measurements. The bulk lifetime of the p‐type as‐grown Si with resistivity ∼10 Ω‐cm is found to be as high as 500 μs for a CZ‐Si crystal with and as high as ∼1 ms or even higher for a low‐oxygen CZ‐Si crystal with. The as‐grown bulk lifetime is revealed to depend not only on resistivity under the framework of the Shockley‐Read‐Hall (SRH) relation, but also on the oxygen concentration. The dominant recombination center of the as‐grown crystal is found to be an SRH‐type deep‐level center which is considered to be an oxygen‐related defect complex. The complex is quenched easily by a heat‐treatment at a temperature as low as 650°C. Effective density of a recombination center, existing after the 650°C heat‐treatment in the p‐type crystal, correlates well with the amount of oxygen precipitation generated by a subsequent two‐step heat process . Thus the dominant recombination center after the 650°C heat‐treatment is considered to be closely related to the oxygen precipitation nuclei toward the subsequent precipitation formation heat process.
Cooperative IP header compression for parallel channels in wireless meshed networks (2005)

In this paper we introduce a novel header compression technique for parallel channels as they are found in meshed networks. The approach introduced advocates the cooperative behavior of parallel channels to maintain the compression state on sender and receiver side. The general concept as well as one particular implementation are shown. Our approach is characterized by no need of a feedback channel and a low complexity of a compression strategy. By means of analytical study combined with our testbed results we show the performance of the introduced approach. The designing goals were to have a low complex, highly efficient and also robust header compression dealing with the characteristics of the wireless channel. As a first result we can show that for independent error pattern a number of three cooperative channels achieves both robustness and efficiency for a wide range of errors.
Patent foramen ovale is not associated with an increased risk of stroke recurrence (2010)

Our data suggest that the risk of recurrent stroke in subjects with PFO is not significantly increased in comparison with subject without it.
Autonomic Ship Concept (1995)

ABSTRACT The Autonomic Ship concept as developed by the Carderock Division, Naval Surface Warfare Center's Innovation Center addresses leveraging advanced computer technology to achieve total systems integration, automation and manning reduction in future ships. The concept integrates distributed architecture, information technologies, and modular systems that utilize the four Autonomic principles; fault tolerant systems, software objects, ubiquitous computing and task and functional analysis. Simply, the vision of the Autonomic Ship can be described as a ship where the people decide what to do and the ship makes it happen .
Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD (2014)

An evolutionarily conserved unfolded protein response (UPR) component, IRE1, cleaves XBP1/HAC1 introns in order to generate spliced mRNAs that are translated into potent transcription factors. IRE1 also cleaves endoplasmic-reticulum-associated RNAs leading to their decay, an activity termed regulated IRE1-dependent decay (RIDD); however, the mechanism by which IRE1 differentiates intron cleavage from RIDD is not well understood. Using in vitro experiments, we found that IRE1 has two different modes of action: XBP1/HAC1 is cleaved by IRE1 subunits acting cooperatively within IRE1 oligomers, whereas a single subunit of IRE1 performs RIDD without cooperativity. Furthermore, these distinct activities can be separated by complementation of catalytically inactive IRE1 RNase and mutations at oligomerization interfaces. Using an IRE1 RNase inhibitor, STF-083010, selective inhibition of XBP1 splicing indicates that XBP1 promotes cell survival, whereas RIDD leads to cell death, revealing modulation of IRE1 activities as a drug-development strategy.
Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome (2015)

Glutamic acid decarboxylase 65 (GAD65) and autoantibodies specific for GAD65 (GADA) are associated with autoimmune diseases including Stiff Person Syndrome (SPS) and Type 1 diabetes (T1D). GADA is recognized as a biomarker of value for clinical diagnosis and prognostication in these diseases. Nonetheless, it remains medically interesting to develop sensitive and specific assays to detect GAD65 preceding GADA emergence, and to monitor GADA-GAD65 immune complexes in blood samples. In the present study, we developed a highly sensitive proximity ligation assay to measure serum GAD65. This novel assay allowed detection of as little as 0.65 pg/ml GAD65. We were also able to detect immune complexes involving GAD65 and GADA. Both free GAD65 and GAD65-GADA levels were significantly higher in serum samples from SPS patients compared to healthy controls. The proximity ligation assays applied for detection of GAD65 and its immune complexes may thus enable improved diagnosis and better understanding of SPS.
Impact of reproductive aging on the vaginal microbiome and soluble immune mediators in women living with and at-risk for HIV infection (2019)

HIV+ postmenopausal compared to premenopausal participants have less CVL E. coli bactericidal activity, reflecting a reduction in Lactobacilli and a greater proportion of Gardnerella and A. vaginae, and more HSV-2 inhibitory activity, reflecting increased mucosal inflammation. The effect of menopause on mucosal immunity was greater in HIV+ participants, suggesting a synergistic impact. Promotion of a lactobacillus dominant vaginal microbiome and reduced mucosal inflammation may improve vaginal health and reduce risk for shedding of HIV and potential for HIV transmission in HIV+ menopausal women.
Nanotechnologies et Génie Civil, comment coopérer pour innover ? (2010)

On discute la gestion de projet innovant à partir de l'exemple du projet Nanosonar, un projet de coopération entre le CEA-LETI et le LCPC visant au développement de nanocapteur innovant pour le suivi de durabilité en génie civil.
Hydrogenation by Raney Nickel Catalyst without Gaseous Hydrogen (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenation by Raney Nickel Catalyst without Gaseous HydrogenRalph Mozingo, Claude Spencer, and Karl FolkersCite this: J. Am. Chem. Soc. 1944, 66, 11, 1859–1860Publication Date (Print):November 1, 1944Publication History Published online1 May 2002Published inissue 1 November 1944https://pubs.acs.org/doi/10.1021/ja01239a014https://doi.org/10.1021/ja01239a014research-articleACS PublicationsRequest reuse permissionsArticle Views955Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CHANGES IN FREE FATTY ACIDS OF BRAIN BY DRUG‐INDUCED CONVULSIONS, ELECTROSHOCK AND ANAESTHESIA (1971)

Abstract— The size of the free fatty acid pool in rat brain was significantly increased following convulsions induced by pentylenetetrazol as well as by electroconvulsive shock. Other convulsants such as d ‐methionine‐ dl ‐sulphoximine and the dibutyryl analog of adenosine 3′,5′‐monophosphate did not alter the levels of free fatty acids. Diethyl ether anaesthesia suppressed the stimulatory effect of electroshock on the generation of free fatty acids in brain, but the effect was not seen with the anaesthetic pentobarbitone sodium. The lack of an inhibitory effect of either anaesthetic on the free fatty acid production which was induced in brain by ischaemia supported the view that the action of electroshock was not merely the result of anoxia. The prominent increase in size of the free fatty acid pool in brain thus appeared to be specific for electroshock‐ and pentylenetetrazol‐convulsed rats. We have proposed that the changes in the free fatty acids might be involved in the regulation of membrane functioning.
Differential-revelation VCG mechanisms for combinatorial auctions (2003)

Combinatorial auctions, where bidders can submit bids on bundles of items, are attractive when the bidders' valuations on bundles exhibit complementarity and/or substitutability. An important problem is that of eliciting the bidders' preferences so that they do not have to bid on all combinations. We present a new family of preference elicitation algorithms. The algorithms in this family do not rely on absolute bids, but rather on relative (differential) value information. This holds the promise to reduce revelation and communication significantly. We develop a differential-elicitation algorithm that finds the efficient allocation of items to the bidders, and as a side-effect, the Vickrey payments (which make truthful bidding incentive compatible). We also present two auction mechanisms that use differential elicitation.
<title>All-optical photonic devices</title> (1997)

Importance of acousto-optical devices in photonics as a modulator, Q-switch, passive-mode locker is well known. In these devices the acoustic signal or ultrasound is generated in a solid medium using an electronic signal applied to a transducer bonded to the acousto-optic medium. However, it is well-known that ultrasound can also be generated using high power light pulses incident on the medium. This method not only avoids the use of transducer and electronics associated with it but also has the potential of performing acousto-optic interaction in the terahertz regime using femto-sec pulses. Some preliminary experiments have been performed using LiNiO<SUB>3</SUB> SAW delay line and a beam splitter. Results indicate that once optimized, these devices are useful and efficient.
Recent Advances in the Atmospheric Pressure PE‐CVD of Fluorocarbon Films: Influence of Air and Water Vapour Impurities (2009)

Abstract The influence of air and water vapour on the deposition process of fluoropolymers in argon‐hexafluoropropene (Ar‐C 3 F 6 ) filamentary dielectric barrier discharges was investigated by adding known concentrations of these contaminants to the feed gas. The obtained results show that Ar‐C 3 F 6 DBDs allow in depositing thin films with a XPS F/C ratio as high as 1.7. Under the experimental conditions investigated, contaminant addition slightly affects the F/C ratio of the coatings, and does not cause appreciable O‐ and N‐uptake, but induces a decrease of the deposition rate. Preliminary results from the OES investigation of the gas phase and the GC‐MS analysis of the gas effluent are also reported.
Adoptive T Cell Immunotherapy (2008)

Adoptive T cell immunotherapy is defined as the passive transfer of tumor-reactive T cells into the tumor-bearing host that results in the direct or indirect destruction of established tumors. Efforts to improve the response rate of Adoptive cellular therapies (ACT) with genetically engineered lymphocytes have been directed at optimizing the gene transduction as well as identifying higher avidity T cell receptor (TCR). Subsequently, the majority of lymphocytes studies in ACTs have broadly focused on two lymphocyte groups: tumor-infiltrating lymphocytes and tumor-specific, major histocompatibility complex class I–restricted, cytotoxic T lymphocytes. Lymph nodes are important secondary lymphoid organs where dendritic cells interact with T cells to initiate a primary immune response. The chapter examines alternative vaccine strategies to prime draining lymph nodes as a means of eliciting effector cells for adoptive immunotherapy. The initial success of genetically engineered lymphocytes has stimulated efforts to further identify the optimal TCR for transduction.
Influence of the Simulation Method on 7th Grade Students' Achievements in Science and Technology Lessons (2015)

This study aimed to make a comparative analysis of seventh-grade (the second level of the primary education) students&#039; achievement in &quot;Systems of The Human Body&quot; unit in Science and Technology lesson which was taught using both the simulation method and the traditional method along with the influence of these methods on students&#039; learning. The study was conducted in collaboration with 70 students enrolled in the seventh grade at an elementary school in Konya in the 2009-2010 academic years for five weeks. Thirty-five students were included in the experimental group and 35 in the control group. The study had the pretest and post-test validity; the reliability of the study was also checked (Cronbach&#039;s alpha = 0.831) and 30 questions were used in Science and Technology Achievement Test. The findings attained from the tests were analyzed using the SPSS Package Program. The study revealed that there was a statistically significant difference between the learning of the two groups, one of which was taught using the simulation method while the other was provided with the traditional method (p&amp;lt;0.05). It was found that the training given using the simulation method created a significant difference to the benefit of the students.