gebhart/patrepeval huggingface dataset:
Bladder and Prostate Cancer (2019)

This chapter summarizes the state of the literature on several promising plant-based therapies that are commonly used in the management of prostate and bladder cancer, discussing mechanisms of action, effectiveness, and highlighting areas for further research. Evidence supporting the role of green tea in bladder cancer is only restricted to animal models and cell-based studies. Preclinical data on the use of green tea for chemoprevention of prostate cancer were generated using the transgenic adenocarcinoma mouse protocol model, an animal model of mice that are genetically engineered to develop prostate adenocarcinoma. The chemopreventive and chemotherapeutic effects of silibinin in bladder cancer have also been investigated. Human studies examining the effects of the more promising Salvia species are, sadly, lacking. However, this plant genus remains a promising area of research. Several complementary and alternative medicine (CAM) agents exist in combination within the same preparation. The most well-known combined CAM therapy that has been used in prostate cancer is PC-SPES.
Effects of Texture and Composition on Mechanical Behavior of Experimentally Deformed Carbonate Rocks (1979)

Dry, low-porosity carbonate rocks with a wide range of texture and dolomite content were experimentally deformed at room temperature, strain rate of 10-4 sec-1, and at confining pressures of 0, 50, and 100 MPa (1 MPa = 10 bars = 145 psi) to evaluate the effects of texture and composition on ultimate strength and ductility. Of all the factors considered, weighted mean grain size and microcrystalline carbonate (micrite) content have the highest linear correlation coefficients with ultimate strength. Grain size is, therefore, the dominant intrinsic rock property that affects ultimate strength in low-porosity carbonate rocks. Systematic increases in total dolomite content (determined by X-ray diffraction) do not correlate significantly with ultimate stre gth when all of the variously textured rocks are compared. However, ultimate strength does increase with increasing dolomite content in rocks of similar texture. The approximate ultimate strengths of carbonate rocks with intermediate dolomite and/or micrite content can be predicted by the best-fit plane to the ultimate strengths of pure end members (Yule marble, Solenhofen limestone, Hasmark dolomite, Blair dolomite). For experiments at 100 MPa confining pressure, this plane is defined by the equation: 0.90 D + 2.07 M + 269 = ^sgru, where D is dolomite content in percent, M is microcrystalline carbonate content in percent, and ^sgru is ultimate strength in MPa. The equation of the plane defined by ultimate strengths of rocks of intermediate composition and texture is: 1.07 D + 2.29 M + 258 = ^sgru. The mean difference between the strengths predicted by these two planes is only 9 MPa. Most precursive microfractures in nonmicritic elements are intragranular. Although the density of intragranular microfractures increases with increasing confining pressure, grain boundary cracks are suppressed by confining pressure. Very few microfractures occur in the micrite itself. At a given confining pressure, highly micritic rocks exhibit much less abundant precursive microfractures than coarser grained rocks, and hence they are stronger.
Delay-range-dependent robust output-feedback stabilization for Markovian jump systems with mode-dependent time delays and nonliearities (2010)

This paper is concerned with the exponential mean-square stabilization problem via dynamic output-feedback controller for Markovian jump systems with nonlinear perturbations and time delays. Sufficient delay-range-dependent stabilization conditions for the existence of robust output-feedback controller are proposed in terms of linear matrix inequalities (LMIs) with equality constraints. Since the obtained conditions are not strict LMI conditions, a globally convergent algorithm involving convex optimization based on the sequential linear programming matrix is suggested to solve the matrix inequalities characterizing the output-feedback controller solutions. It is shown that the maximum allowable bound on the nonlinearity could be computed thorough solving a constraint optimization problem. Finally, an illustrative example is given to show the effectiveness of the proposed approach.
Fertility after treatment for cancer (1999)

An increasing number of people are being successfully treated for cancer, and for those with an expectation of long-term survival the late effects of treatment are of concern. Young people have a particular interest in the impact of chemotherapy or radiotherapy on their future fertility, and recent media reports1 of the successful transplantation of cryopreserved autologous ovarian tissue into a previously oophorectomised woman with non-malignant disease (K Oktay et al, Annual Meeting of American Society for Reproductive Medicine, Toronto, September 1999) will have caught the imagination of many. If a technique works in this situation, why not for a woman with malignancy whose ovarian tissue might be harvested before the start of sterilising chemotherapy?

Successful transplantation of cryopreserved ovarian cortical tissue into castrated ewes was first performed by Gosden and colleagues in 19942: a return of oestrus cycles was observed, and, after normal mating, conceptions occurred and lambs were born. Further work in women suggests that small pieces of …
Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level (2015)

Detection of a single nucleic acid molecule is of great significance for both fundamental biochemistry studies and clinical diagnostics. By using microRNA (miRNA) as a model target, herein, we have developed a single-microbead-based sensing (SMBS) platform, which simply enables the detection of miRNA at the single-molecule level. In this strategy, an isothermal exponential amplification reaction (EXPAR) is rationally designed towards specific miRNAs and all products of the EXPAR are integrated onto a single microbead for signal amplification and fluorescence enrichment. This pushes the detection of miRNAs down to 1 aM in a 5 μL sample, corresponding to 3 copies of the miRNA molecule. This new strategy also affords high selectivity and it is capable of distinguishing among homologous miRNA family members even with a single-base difference. Due to its ultrahigh sensitivity and selectivity, the proposed SMBS platform has been successfully applied to the detection of miRNA extracted from a single cell.
ARTIFICIAL NEURAL NETWORKS BASED DYNAMIC WEIGHT ESTIMATION WITH OPTICAL ARRANGEMENT (2010)

In this essay, an optical arrangement for the measurement of dynamic weight, by means
of conducting a thin ray of light through it, is designed in order to enhance the measuring accuracy in the
weight-estimation device. In this arrangement, CCD is responsible for producing raw data for processing.
An articial neural network type, RBF, is also used to improve the quality and speed of the measurement.
While the scale of the weight-estimation device is oscillating, by applying the weight on the scale, the
neural network by sampling the proportionate wave-shape yields the weight of object with high accuracy
and high speed.
Cooperative description of type cultures of Streptomyces. IV. Species descriptions from the second, third and fourth studies (1969)

The International Streptomyces Project is a cooperative effort by more than 40 collaborating laboratories representing 18 nations to assemble and redescribe authentic type strains or acceptable neotype strains for species of the genera Streptomyces and Streptoverticillium. Descripktions based upon currently acceptable criteria and methods are published in the International Journal of Systematic Bacteriology. Specimens of the redescribed type strains are deposited in the American Type Culture Collection, the Centraalbureau voor Schimmelcultures, the U. S. S. R. Research Institute for Antibiotics and the Institute for Fermentation, Japan. This report adds descriptions for type strains of 100 additional species to the 200 species previously deposited in the collections and described in Parts II and III of this series.
Induction of Unexpected Left‐Handed Helicity by an N‐Terminal <scp>L</scp>‐Amino Acid in an Otherwise Achiral Peptide Chain (2012)

Peptide helices containing L-amino acids are typically right-handed. Exceptions are peptide helices containing the achiral amino acids 2-aminoisobutyric acid and glycine with a single chiral amino acid at the N terminus. These helices are left-handed when the N-terminal residue is a common tertiary proteinogenic amino acid, such as L-valine (see picture, left), but right-handed when the N-terminal residue is the quaternary amino acid L-α-methylvaline (right). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
<i>Demodex</i> mites in acne rosacea (1998)

The hair follicle mites Demodex folliculorum and Demodex brevis and their role in the pathogenesis of rosacea have been the subject of much debate in the past. We studied the prevalence of Demodex mites in facial skin biopsies obtained from 80 patients with rosacea, 40 with facial eczematous eruption and 40 with lupus erythematosus discoides. The mite prevalence in the rosacea group (51%) was significantly higher than in the rest of the study population (eczema 28% and lupus discoides 31%). Demodex mites were found on all facial sites. The most infested areas in the whole study group were the forehead (49%) and the cheeks (44%). Males were more frequently infested (59%) than females (30%). We did not find any significant difference in mite counts of infested follicles between rosacea and the control group. A lympho-histiocytic cell infiltration was seen around the infested hair follicles. Our results suggest that Demodex mites may play a role in the inflammatory reaction in acne rosacea.
Co-infection with gonorrhoea and chlamydia: how much is there and what does it mean? (2003)

A cross-sectional study of new clients with either gonorrhoea or chlamydia attending King's College Hospital in 1998. One thousand two hundred and thirty-nine women and 1141 men had gonorrhoea, chlamydia or both. Overall, 24.2% (124/512) of heterosexual men and 38.5% (136/353) of women with gonorrhoea also had chlamydia (P<0.001). Of heterosexual males 18.8% (124/660) and 13% (136/1022) of females with chlamydia also had gonorrhoea (P=0.002). Ethnicity had no effect on the proportion of co-infection after controlling for age and gender. Clients with dual infection were younger than those with either infection alone (P=0.0001). Over half of women and a quarter of men aged 15 to 19 years were dually infected so testing for both gonorrhoea and chlamydia may be appropriate in this age group in settings outside genitourinary clinics. The high proportion of cases of gonorrhoea that also have chlamydia justifies the policy of epidemiological treatment for chlamydia.
A multifrequency interferometric CW radar for vital signs detection (2009)

The use of radar techniques to detect minute body movements which are associated with respiration and cardiac activity (vital signs) is known at least since 1975 when J.C. Linn and J. Salinger proposed a non-contact microwave respiration monitor. This paper sets up to discuss further development of CW radar based vital signs detection systems. The purpose here is to enhance target detection probability in a highly cluttered environment and to add range and angle-of-arrival estimation without dramatically enhancing RF spectrum requirements by transition to a multicarrier interrogating signal.
Current Status of Targeted Therapy for Anaplastic Lymphoma Kinase–Rearranged Non–Small Cell Lung Cancer (2013)

The identification of chromosomal rearrangements involving the anaplastic lymphoma kinase (ALK) gene in ~3-5% of non-small cell lung cancer (NSCLC) tissues and the demonstration that the first-in-class ALK tyrosine kinase inhibitor, crizotinib, can effectively target these tumors represent a significant advance in the evolution of personalized medicine for NSCLC. Single-arm studies demonstrating rapid and durable responses in the majority of ALK-positive NSCLC patients treated with crizotinib have been followed by a randomized phase III clinical trial in which superiority of crizotinib over chemotherapy was seen in previously treated ALK-positive NSCLC patients. However, despite the initial responses, most patients develop acquired resistance to crizotinib. Several novel therapeutic approaches targeting ALK-positive NSCLC are currently under evaluation in clinical trials, including second-generation ALK inhibitors, such as LDK378, CH5424802 (RO5424802802), and AP26113, and heat shock protein 90 inhibitors.
Preparation of reactive mineral powders used for poly(sodium acrylate) composite superabsorbents (2005)

Abstract Reactive mineral powders were prepared with a vinyl monomer as an intercalating agent, which was grafted onto the surface of nanoclay layers, to offer crosslinking points between the nanoclay layers. According to IR characterization, the vinyl group of (3‐acrylamidopropyl)trimethylammonium chloride, grafted onto the clay, disappeared after polymerization was performed. This spectral evidence confirmed that the reaction occurred between the clay layers. Thermogravimetric curves showed that the weight percentage remaining at 750°C for the intercalated clay/sodium acrylate nanocomposites was about 5 wt % higher than that for organic poly(sodium acrylate). This indicated that the clay was not diminished in the polymerization, and this process produced intercalated mica with a quaternary ammonium content of approximately 38.8 mmol/100 g and intercalated montmorillonite with a quaternary ammonium content of approximately 45.36 mmol/100 g. We also investigated the effect of reactive clays on the crystalline morphology and water absorbency for these nanocomposite hydrogels. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 97: 855–861, 2005
Nickel complexes of N-substituted iminodiacetates in aqueous solution: co-ordination by the hydroxyl group of hydroxyalkyl substituents (1976)

Nickel(II) complexes of substituted iminodiacetates, RN(CH2CO2–)2, have been studied in aqueous solution [R = Et, Prn. Pri, Bun, Bui,Bus, But, n- and t-pentyl, HOCH2CH2, HOCHMeCH2, HOCH2CHMe, HOCMe2CH2, HOCH2CMe2, HO(CH2)3, HO(CH2)4, and HO(CH2)5]. Stability constants have been determined for the 1 : 1 and 1 : 2 complexes; comparisons among the values found support earlier suggestions that the substituent hydroxyl group is co-ordinated only in the 1 : 1 complexes with the HO(CH2)3, ligand and with all the hydroxyethyl ligands. The proton resonance spectra of the complexes confirm these suggestions. At < 0 °C, the complex with R = HO(CH2)3 shows a spectrum typical of a rigid puckered conformation for the six-membered chelate ring formed by this substituent group. Electronic spectra and magnetic moments have also been determined for the complexes: they are consistent with approximately octahedral co-ordination around the nickel.
Secure cloud video streaming using tokens (2014)

Nowadays, many applications benefit from the increasing number of resources that cloud computing provides in order to improve the quality of their services. Most of these services require an account in order to access different resources, limiting their users to personal devices for the benefit of security, i.e., a (possible) malicious device should not be used to authenticate. In this paper we introduce a novel architecture that allows sharing temporary and limited credentials with any device in order to increase the usability of cloud-based services. We show the efficiency and easiness to use of our solution by implementing video streaming service using well-known public cloud computing and a common and cost-efficient hardware.
IMAS and PPE Requirements (2003)

This paper explains the personal protective equipment (PPE) that a demining group must use in order to comply with the United Nations’ International Mine Action Standards (IMAS). The author was an active member of the User Focus Group advising the Geneva International Centre for Humanitarian Demining (GICHD) when they made the current IMAS revision. He continues as an elected member of the IMAS Review Board. The author has also maintained a database of demining accidents for five years, and uses the evidence of real accidents to inform his views on protection needs.
An Efficient, Secure and Reliable Search Scheme for Dynamic Updates with Blockchain (2019)

Blockchain is a newly emerged technology to maintain data consistency through distributed network. Due to the nature of tamper-resistance, blockchain can well be used to achieve secure and reliable search without the participation of any third party. For data storage system with frequent updates, unfortunately, the existing blockchain-based search methods do not work. In this paper, we try to solve this problem by proposing a highly efficient search scheme for dynamic updates while still using blockchain to ensure security and reliability. Instead of modifying the original index directly, our updates are implemented by appending new indices when adding new data and maintaining a revocation list when deleting or changing data. Note that, the index tables and revocation list are preserved through dynamic searchable encryption, achieving high efficiency as well as security. Thus, attacker cannot learn if the newly added file contains a keyword that was searched before or not, so it can resist file-rejection attacks. Finally, we set up a blockchain-based search framework and validate the effectiveness and practicability of our method.
Improved Experimental Model for Measuring Skin Degerming Activity on the Human Hand (1972)

A gloved-hand method is presented for evaluating the interaction of antimicrobial agents with the normal resident bacterial flora of human skin. One of the key features of the experimental model is a simplified technique for sampling the skin, which involves the addition of eluting fluid to the gloved hand. As with other skin sampling techniques, the number of bacteria recovered from the hands showed considerable variation from subject to subject. However, no significant differences were observed between the numbers of bacteria recovered from the right and left hands of individual subjects. The mean number of bacteria recovered from the hand before and after washing with nonmedicated soap was consistent and reproducible over a period of at least 5 consecutive days. The number of recoverable bacteria from the hand was greatly reduced by a single treatment with a surgical scrub preparation containing hexachlorophene. The extent of skin degerming achieved was little affected by the use of a surgical brush, and was maximal at approximately 30 min after contact with the hexachlorophene-containing formulation. It was determined that the level of transient bacteria on the hands could be controlled by a simple wash with nonmedicated soap, resulting in a stabilized base-line level from which treatment interactions with the resident microflora could be measured more precisely. The basic elements of the method presented fulfill the requirements of a satisfactory experimental model for the in vivo evaluation of skin-degerming agents on the hand. The selection of appropriate experimental designs allows treatment comparisons to be made with a high degree of statistical confidence.
Hydroxy Sulfonated Fatty Acid Esters as Surface Active Agents III: Kinetics of the Synthesis (1969)

Abstract Kinetics of synthesis of a new type of surface active agents having the general formula RCOOCH 2 CHOHCH 2 SO 3 M, where M is an alkali metal or other basic radical, have been studied. Synthesis of hydroxy sulfonated fatty acid esters of oleic and lauric acids by the reaction of molar proportion of sodium chlorohydroxy propane sulfonate with fatty acid soap (formed in situ) was found to be a pseudo‐first order reaction. The energy of activation was calculated from Arrhenius equation as 25.7 kcal/mole. Paper chromatographic method has also been used for kinetic studies.
Feline Factor XII (Hageman) Deficiency (1977)

A coagulation profile from a clinically normal female cat revealed an intrinsic coagulation defect characterized by prolonged activated partial thromboplastin time, with normal bleeding time, platelet count, and prothrombin time. Subsequent correction studies, utilizing activated partial thromboplastin time, confirmed factor XII deficiency. Hematologic and clinical studies on the cat failed to reveal an underlying disease process that might result in acquired factor XII deficiency.
Salmon calcitonin in the treatment of hypercalcemia (1973)

Synthetic salmon calcitonin was evaluated in 23 patients with hypercalcemia of different causes treated continuously or intermittently for periods from one day to two months. Clinically important decreases in serum calcium level were achieved in 17. The response was only partial; often the serum calcium descended from dangerously high levels to a tolerable range or to minimal hypercalcemia. The drug was nontoxic, and hypersensitivity did not occur, in spite of recommencement of therapy after days or weeks of cessation. Salmon calcitonin was found to be particularly useful as an initial emergency drug for hypercalcemic patients with heart failure or azotemia or both. It often facilitated the clinical improvement that was necessary for these patients to tolerate more definitive therapy or other hypocalcemic agents.
Anthocyanins from Black Chokeberry (<i>Aroniamelanocarpa</i> Elliot) Delayed Aging-Related Degenerative Changes of Brain (2017)

Aging is the greatest risk factor for most neurodegenerative diseases, which is associated with decreasing cognitive function and significantly affecting life quality in the elderly. Computational analysis suggested that 4 anthocyanins from chokeberry fruit increased Klotho (aging-suppressor) structural stability, so we hypothesized that chokeberry anthocyanins could antiaging. To explore the effects of anthocyanins treatment on brain aging, mice treated with 15 or 30 mg/kg anthocyanins by gavage and injected D-galactose accelerated aging per day. After 8 weeks, cognitive and noncognitive components of behavior were determined. Our studies showed that anthocyanins blocked age-associated cognitive decline and response capacity in senescence accelerated mice. Furthermore, mice treated with anthocyanins-supplemented showed better balance of redox systems (SOD, GSH-PX, and MDA) in all age tests. Three major monoamines were norepinephrine, dopamine, and 5-hydroxytryptamine, and their levels were significantly increased; the levels of inflammatory cytokines (COX2, TGF-β1, and IL-1) transcription and DNA damage were decreased significantly in brains of anthocyanins treated mice compared to aged models. The DNA damage signaling pathway was also regulated with anthocyanins. Our results suggested that anthocyanins was a potential approach for maintaining thinking and memory in aging mice, possibly by regulating the balance of redox system and reducing inflammation accumulation, and the most important factor was inhibiting DNA damage.
Computer networks for retail stores (1973)

In this paper we attempt to define some of Jewel's needs for data collection and data communications and some of our approaches to satisfying these needs. In order to make this discussion meaningful, we first describe the company to the extent necessary to make our applications understandable. Then we discuss our data processing applications to indicate how we have solved some difficult problems.