gebhart/patrepeval huggingface dataset:
TH‐D‐BRB‐04: Ion Chamber Dosimetry Modification under Strong Magnetic Field Conditions (2010)

Purpose : To examine the dose response of an ion chamber in an external magnetic field and to simulate the energy deposition using the Monte Carlo technique. Method and Materials : This work investigates the response of a 0.6cm 3 Farmer chamber to an 11.17 mCi 137 Cs source under the influence of a 1.5 T magnetic field on a GE MRI scanner. A wooden frame was designed that allowed varying field direction measurements while keeping the source to chamber axis distance constant. Monte Carlo simulations were conducted using FLUKA a particle physics transport package to score the energy deposition and the average electron track length inside the cavity. Results : Higher chamber current readings were obtained when a transverse (to chamber central axis) magnetic field was applied compared to zero B field conditions. Lower readings were obtained when a longitudinal field was present. A 4.8% increase was observed for the transverse field measurements and negative voltage polarity while a 3.5% decrease was measured for the longitudinal case. The positive polarity measurements showed a 3.7% increase and an 11.5% decrease in transverse and longitudinal fields vs. a 4.0% increase and a 6.0% decrease found through Monte Carlo simulations. The average track length increased by 11.0% and decreased by 6.8% in transverse and the longitudinal fields.Varying the electric field applied to the electrodes showed no significant changes in chamber response. Conclusion : The dose response of a Farmer chamber in an external magnetic field varies with the average charged particle trajectory length. The average trajectory depends on the B field magnitude and direction and on the energy spectrum of the primary photon beam. Thus an alignment with the B field direction would be essential. Smaller cavity chambers are expected to be affected less under B field conditions and should be investigated in the future.
Nuclear magnetic resonance studies of preferential solvation. Part 1.—Hydrogen peroxide + water (1973)

Studies of the alkali metal (7Li, 23Na, 87Rb, 133Cs) and halide (19F, 35Cl) resonance chemical shifts have been made in H2O2+ H2O solvent mixtures up to 85 % w/w peroxide with the addition of 10–3 mol kg–1 ethylenediaminetetra-acetic acid (EDTA) to complex transition metal ion impurities. When the chemical shifts were dependent on salt concentration, results were extrapolated to zero salt concentration. The variation of these infinite dilution shifts with peroxide mole fraction shows Rb+, Cs+ and F– to be preferentially solvated by peroxide and Li+ preferentially solvated by water. These conclusions can be put on a quantitative basis by assuming that the solvation changes can be represented by a series of n competitive equilibria, where n is the solvation number, assumed to be the same for both water and peroxide. The free energy of preferential solvation has been determined where ΔG⊖ps=–RT ln K and K is the equilibrium constant for the overall process X(H2O)n+ H2O2⇌ X(H2O2)n+nH2O. K is related to the equilibrium constant for the ith step by K=[iKi/(n+ 1 –i)]n. The relation of ΔG⊖ps to the free energy of transfer of a neutral combination of ions from one solvent to another, ΔG⊖t, is discussed.
Enabling cognitive-radio paradigm on commercial off-the-shelf 802.11 hardware (2013)

Cognitive Radio paradigm (CR) is recognized as key enabler for next generation wireless networking: accessing the limited radio spectrum in an opportunistic manner allows secondary users to boost their transmission performance without interfering with existing primary networks. Full testing and experimenting with this paradigm, however, is still a tough task, given either the i) limited capabilities above the PHY layer of cheap SDR solutions, or the ii) heavy investment required for setting up multi-node testbeds powered by FPGAs. In this demo we show how we leveraged our Wireless MAC Processor architecture to tackle the two issues at the same time, providing a highly reconfigurable cognitive solution for wireless local area networks on top of commercial off-the-shelf (COTS) 802.11 devices. We demonstrate a typical CR use case where local and network-wide cognitive loops interact for configuring secondary users real time channel switching in reaction to channel state mutation. We also prove the flexibility of our Wireless MAC Processor (WMP) architecture for extensive testing of the CR paradigm.
Synthesis and characterisation of pentaphenylcyclo-pentadienyliron arene sandwich complex cations [Fe(η<sup>5</sup>-C<sub>5</sub>Ph<sub>5</sub>)(arene)]<sup>+</sup>and the X-ray crystal structure of the [Fe(η<sup>5</sup>-C<sub>5</sub>Ph<sub>5</sub>)(η<sup>6</sup>-C<sub>6</sub>H<sub>5</sub>Me)]<sup>+</sup>cation (1991)

A series of [Fe(η5-C5Ph5)(η6-arene)]+ complex cations [arene = benzene, toluene, o-, m- and p-xylene, mesitylene, durene (1,2,4,5-tetramethylbenzene) or hexamethylbenzene] is reported. The structure of the cation of the toluene derivative was determined by single-crystal X-ray diffraction [refined to R 0.034, R′ 0.038 with 4328 data having I 2.5σ(I)]. It crystallises from acetone as discrete molecules in the monoclinic space group P21/n, with a= 10.016(2), b= 21.568(6), c= 16.920(4)Å, β= 92.17(2)° and Z= 4. The cyclopentadienyl ring binds in an η5 fashion and the Fe–C (C6 ring) bond distances average 2.093(3)Å; the Fe–C (C5 ring) bond distances average 2.113(4)Å. The Fe–C (C5 ring plane) and Fe–C (C6 ring plane) distances are 1.702(5) and 1.588(5)Å, respectively. All complexes exhibit two reversible reductions.
Phase Locking Large Arrays of Lasers via a Single Degenerate Cavity (2011)

Experimental realization for phase-locking large arrays of lasers arranged in a variety of 2D geometries is presented. Using our degenerate-cavity coupling between lasers is easily controlled giving rise to a variety of intriguing phase structures.
Space–bandwidth product adaptation and its application to superresolution: fundamentals (1997)

Superresolution has been an active field during the last 50 years. Many approaches for achieving superresolution have been suggested, all based on having a priori information on the signal. We discuss the space–bandwidth product adaptation process, which is a generalization of all previous approaches. This new point of view is based on handling the Wigner chart of the input signal as well as the Wigner chart of the signal that can be accepted by the system. We also take into account the number of degrees of freedom of the signal and the system. Examples that demonstrate the suggested approach are illustrated in a companion paper [J. Opt. Soc. Am. A14, 563 (1997)].
Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte (2016)

APOL1 nephropathies comprise a range of clinical and pathologic syndromes, which can be summarized as focal segmental glomerulosclerosis, in various guises, and arterionephrosclerosis, otherwise known as hypertensive kidney diseases. Current therapies for these conditions may achieve therapeutic targets, reduction in proteinuria and control of blood pressure, respectively, but often fail to halt the progressive decline in kidney function. It appears that current therapies fail to address certain underlying critical pathologic processes that are driven, particularly in podocytes and microvascular cells, by the APOL1 renal risk genetic variants. Mechanisms hypothesized to be responsible for APOL1 variant-associated cell injury can be summarized in five domains: increased APOL1 gene expression, activation of inflammasomes, activation of protein kinase R, electrolyte flux across plasma or intracellular membranes, and altered endolysosomal trafficking associated with endoplasmic reticulum stress. We briefly review the available evidence for these five mechanisms and suggest possible novel therapeutic approaches.
[New findings on the immunologic diagnosis of systemic lupus erythematosus]. (1993)

The authors review recent findings pertaining to the pathogenesis of systemic lupus erythematosus. It was revealed that knowledge of impaired humoral and cellular immunity is of great practical importance and substantially improves the prognosis of the disease.
Perinatal Inflammation Influences but Does Not Arrest Rapid Immune Development in Preterm Babies (2019)

Abstract Infection and infection-related complications are important causes of death and morbidity following preterm birth. Despite this, there is limited understanding of the development of the immune system in those born prematurely and how it is influenced by perinatal factors. To investigate this, we prospectively and longitudinally followed a cohort of babies born before 32 weeks of gestation. We demonstrated that preterm babies, including those born extremely prematurely, were capable of rapidly acquiring adult levels of immune functionality; that immune maturation appeared to occur independently of the developing microbiome, which was highly heterogeneous across different infants; and that the biggest drivers of change in the trajectory of perinatal immune development was exposure to infection in utero or post-natally. Conspicuously, a unifying factor among infants who developed infection despite their growing immune potentials was an inability to mount adequate T cell CXCL8 responses. Because this defect was present at birth, it may predict those babies likely to have poor clinical outcomes.
Secreted Aspartic Proteases as Virulence Factors of Candida Species (2002)

Candida infections have emerged as a significant medical problem during the last few decades. Among the different virulence traits of C. albicans, secreted proteolytic activity has been intensively investigated. Pathogenesis of the various forms of candidiasis was shown to be associated with the differential and temporal regulation of the expression of genes coding for secreted aspartic proteases (Sap). These enzymes act as cytolysins in macrophages after phagocytosis of Candida, are present in tissue penetration and are also involved in adherence to epithelial cells. Since the introduction of new antiretroviral therapeutics such as HIV protease inhibitors, oropharyngeal candidiasis is less often observed in AIDS patients. Different HIV aspartic protease inhibitors were able to inhibit the C. albicans Saps involved in adherence. The lower rates of oropharyngeal candidiasis observed in individuals receiving antiretroviral combination therapy could reflect not only an improvement in the immune system but also direct inhibition of Candida Saps by HIV protease inhibitors. Therefore, the development of specific aspartic protease inhibitors might be of interest for the inhibition of candidiasis.
Sensitivity Study of Predictions of an ITG-based Transport Model (1998)

This is a status report of work in progress. Enclosed is the contents of poster Q7S37, as presented at the Fortieth Annual Meeting of the American Physical Society Division of Plasma Physics, New Orleans, November 16-20, 1998 (poster Q7S37, abstract in Bull. American Phys. Soc. 43, 1877 (1998). A more extensive study, with more parameter variations, is in preparation. Among other things, the final report will include modifications to the figures on p. 5 to reflect a further 20% increase in the nonlinear threshold in R/LTi found in recent gyrokinetic simulations (though the addition of collisions and non-adiabatic electrons may offset this).
The Autonomous Microbial Genosensor, an in situ Sensor for Marine Microbe Detection (2007)

Extract Extended abstract of a paper presented at Microscopy and Microanalysis 2007 in Ft. Lauderdale, Florida, USA, August 5 – August 9, 2007
Cyclopropanes. V.<sup>1</sup> The Cyclopropylcarbinyl Rearrangement<sup>2</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclopropanes. V.1 The Cyclopropylcarbinyl Rearrangement2H. M. Walborsky and J. F. PendletonCite this: J. Am. Chem. Soc. 1960, 82, 6, 1405–1410Publication Date (Print):March 1, 1960Publication History Published online1 May 2002Published inissue 1 March 1960https://pubs.acs.org/doi/10.1021/ja01491a031https://doi.org/10.1021/ja01491a031research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SHOTGUN INJURIES (1983)

The Journal of Trauma: Injury, Infection, and Critical Care: July 1983 - Volume 23 - Issue 7 - p 644
Magnetization of compositionally modulated CuNi films (1981)

We report static magnetization measurements on the compositionally modulated ferromagnetic alloy Cu/Ni, which, contrary to earlier ferromagnetic resonance measurements, show the moment per Ni atom is reduced relative to pure Ni. The low-temperature magnetization is found to vary linearly with modulation amplitude, but, surprisingly, the Curie temperature is found to be almost amplitude independent.
AMBIVALENT rII MUTANTS OF PHAGE T4 (1961)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Smart suction device for less blood trauma: a comparison with Cell Saver (2001)

In this experimental set-up, the Smart suction system avoids damage to red cells and affects platelet count less than the Cell Saver system which induces important blood cell destruction, as any suction device mixing air and blood, as well as severe hypoproteinemia with its metabolic, clotting and hemodynamic consequences.
Protein kinase A-dependent inhibition of alkaline phosphatase release by SaOS-2 human osteoblastic cells: studies in new mutant cell lines that express a cyclic AMP-resistant phenotype. (1991)

We have established mutant SaOS-2 cell lines that express a cyclic AMP (cAMP)-resistant phenotype to investigate the regulation and functional importance of orthophosphoric-monoester phosphohydrolase alkaline optimum (ALPase) in the action of parathyroid hormone (PTH). Cells were stably transfected with a plasmid that directs the synthesis of a mutant form of the type I regulatory subunit of protein kinase A (PKA) under the control of the metallothionein promotor. There was no significant difference between parental SaOS-2 cells and the mutant lines in the affinity or number of receptors for 125I-Nle8,18Tyr34bPTH1-34NH2, either in the absence or presence of Zn2+. When cAMP-dependent gene transcription was examined using transient transfection with a somatostatin promoter-chloramphenicol acetyl transferase (CAT) reporter plasmid, CAT activity stimulated by human PTH and dibutyryl cAMP (DBcAMP) was inhibited by greater than 90% in the presence of Zn2+ in the mutant cell lines. In contrast, activation by a phorbol ester of a pentameric collagenase promoter/CAT construct containing five tandem copies of the AP-1 response element (5x-TRE-CAT) was unaffected in Zn(2+)-treated mutant cells. The inhibitory actions of PTH and DBcAMP on ALPase release were blunted by up to 80-90% in the mutant cell lines in the presence of Zn2+; there were no significant differences in the magnitude of inhibitory effects between these agonists. We conclude that the inhibitory action of PTH on ALPase release in SaOS-2 cells is mediated via activation of PKA. These cAMP-resistant cell lines will be especially useful in elucidating signal transduction mechanism(s) for PTH in human osteoblastic cells.
Spatiotemporal connectivity in the mesolimbic system revealed by MEMRI (2010)

Keywords: MEMRI ; manganese ; addiction ; connectivity Reference EPFL-CONF-180059 Record created on 2012-07-13, modified on 2016-08-09
Heptametallic Bowl-Shaped Complexes Derived from Conjugated Schiff-Base Macrocycles:  Synthesis, Characterization, and X-ray Crystal Structures (2006)

The reaction of chelating conjugated macrocycles 1a-c with Zn(OAc)2 gives bowl-shaped heptanuclear Zn complexes featuring Zn in tetrahedral, octahedral, and square-pyramidal geometries. Crystallographic and NMR results indicate that vacant Zn coordination sites within the bowl may be accessed, suggesting that these coordination complexes may be used as mimics for Zn fingers and carbonic anhydrase.
Picosecond Rotation of Small Polar Fluorophores in the Cytosol of Sea Urchin Eggs (1991)

A new fluorescence method to measure viscosity in cell cytosol [Fushimi, K., & Verkman, A. S. (1991) J. Cell Biol. 112, 719-725] has been applied to determine fluid-phase viscosity in sea urchin eggs. Freshly harvested eggs from Lytechinus pictus were loaded with the dyes 2,7-bis(2-carboxyethyl)-5-(and-6-)carboxyfluorescein (BCECF), 6-carboxyfluorescein (6CF), fluorescein, or calcein. Fluorescence lifetimes and anisotropy decay were measured in single eggs by multiharmonic, frequency-domain microfluorometry using a 1-2-micron focused laser spot and 25x air objective. In calibration solutions consisting of glycerol in pH 8 buffered sea water, probe lifetime was single exponential and probe rotation was isotropic with a single correlation time which increased linearly with viscosity in the range 1-3.6 cP. In eggs at 22 degrees C, there were single lifetimes (in nanoseconds) of 3.6 (BCECF), 3.4 (6CF), 3.2 (fluorescein), and 3.3 (calcein). Probe rotation in eggs had two components, a fast component (in picoseconds, mean +/- SE, 10-18 eggs) of 568 +/- 39 (BCECF), 311 +/- 21 (6CF), 313 +/- 15 (fluorescein), and 516 +/- 44 (calcein) and a slow component of 10-40 ns. The fractional amplitude of the fast component, corresponding to unbound dye, was 0.72-0.81. Apparent viscosities of fluid-phase cytoplasm (centipoises) given by the four different probes were in good agreement: 2.3 +/- 0.2 (BCECF), 2.1 +/- 0.1 (6CF), 2.5 +/- 0.1 (fluorescein), and 2.3 +/- 0.2 (calcein). The viscosity in cytosol of sea urchin eggs (2.1-2.5 cP) is thus relatively low, yet significantly greater than that of water (1 cP) or cytosol in cultured fibroblasts (1.2-1.4 cP).(ABSTRACT TRUNCATED AT 250 WORDS)
On the boundedness of the support of optimal input measures for Rayleigh fading channels (2008)

We consider transmission over a wireless multiple antenna communication system operating in a Rayleigh flat fading environment with no channel state information at the receiver and the transmitter. We show that, subject to the average power constraint, the support of the capacity achieving input distribution is bounded. Moreover, we show by a simple example concerning the identity theorem (or uniqueness theorem) from the complex analysis in several variables that some of the existing results in the field are not rigorous.
Gold Nanoparticles for Modulating Neuronal Behavior (2017)

Understanding the detailed functioning and pathophysiology of the brain and the nervous system continues to challenge the scientific community, particularly in terms of scaling up techniques for monitoring and interfacing with complex 3D networks. Nanotechnology has the potential to support this scaling up, where the eventual goal would be to address individual nerve cells within functional units of both the central and peripheral nervous system. Gold nanoparticles provide a variety of physical and chemical properties that have attracted attention as a light-activated nanoscale neuronal interface. This review provides a critical overview of the photothermal and photomechanical properties of chemically functionalized gold nanoparticles that have been exploited to trigger a range of biological responses in neuronal tissues, including modulation of electrical activity and nerve regeneration. The prospects and challenges for further development are also discussed.
Synthesis and Biodistribution of Oligonucleotide-Functionalized, Tumor-Targetable Carbon Nanotubes (2008)

Single-wall carbon nanotubes (SWNT) show promise as nanoscale vehicles for targeted therapies. We have functionalized SWNT using regioselective chemistries to confer capabilities of selective targeting using RGD ligands, radiotracing using radiometal chelates, and self-assembly using oligonucleotides. The constructs contained approximately 2-7 phosphorothioate oligonucleotide chains and 50-75 amines per 100 nm length of SWNT, based on a loading of 0.01-0.05 mmol/g and 0.3-0.6 mmol/g, respectively. Dynamic light scattering suggested the functionalized SWNT were well dispersed, without formation of large aggregates in physiologic solutions. The SWNT-oligonucleotide conjugate annealed with a complementary oligonucleotide sequence had a melting temperature of 54 degrees C. Biodistribution in mice was quantified using radiolabeled SWNT-oligonucleotide conjugates. Appended RGD ligands allowed for specific binding to tumor cells in a flow cytometric assay. The techniques employed should enable the synthesis of multifunctional SWNT capable of self-assembly in biological settings.
ChemInform Abstract: Stereoselective Ring Opening of Electronically Excited Cyclohexa‐2,4‐ dienones: Cause and Effect. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The effects of Ruthenium Red on Ca2+ handling by the heart (1987)

Conference Article| October 01 1987 The effects of Ruthenium Red on Ca2+ handling by the heart JOHN F. UNITT; JOHN F. UNITT *Department of Biochemistry, The University of Leeds, Leeds, LS2 9JT, U.K. Search for other works by this author on: This Site PubMed Google Scholar JAMES G. McCORMACK; JAMES G. McCORMACK *Department of Biochemistry, The University of Leeds, Leeds, LS2 9JT, U.K. Search for other works by this author on: This Site PubMed Google Scholar PAUL J. ENGLAND PAUL J. ENGLAND †Department of Cellular Pharmacology, Smith Kline & French Research Ltd, The Frythe, Welwyn, Herts., AL6 9AR, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1987) 15 (5): 956–957. https://doi.org/10.1042/bst0150956 Article history Received: March 26 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation JOHN F. UNITT, JAMES G. McCORMACK, PAUL J. ENGLAND; The effects of Ruthenium Red on Ca2+ handling by the heart. Biochem Soc Trans 1 October 1987; 15 (5): 956–957. doi: https://doi.org/10.1042/bst0150956 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: RR, Ruthenium Red This content is only available as a PDF. © 1987 Biochemical Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.
Interface-state generation in polysilicon gate devices (1986)

The time dependence of interface-state generation in polysilicon gate MOS devices has been investigated. Interface-states have been detected milliseconds after irradiation, indicating more than one mechanism may be responsible for interface-state generation.