gebhart/patrepeval huggingface dataset:
Abstract LB-236: Imprime PGG conjugated directly to protein enables cross-presentation of antigen that generates multifunctional cytotoxic T cells (2015)

Abstract Imprime PGG is a soluble yeast-derived β-1,3/1,6 glucan innate immune cell modulator that is in phase 3 and multiple phase 2 clinical trials in combination with complement activating monoclonal antibodies (e.g. bevacizumab, cetuximab). We have previously shown that Imprime binds to complement receptors and modulates the function of a variety of immune cells, including monocytes, neutrophils, and B cells. We have also demonstrated that Imprime PGG binds to various subsets of dendritic cells (DCs) and can cause intermediate upregulation of MHC class II and the co-stimulatory molecules CD80/86 critical for antigen presentation and T cell activation. Based on these findings, we hypothesized that Imprime PGG conjugated to a protein would efficiently deliver antigen to DCs and prime a cytotoxic CD8+ T cell response. To test this hypothesis, we employed the model antigen chicken ovalbumin (OVA) in a C57BL/6 mouse model to examine the generation of OVA-specific CD8+ T cell responses. We covalently linked OVA to Imprime PGG to generate a β-glucan/protein conjugate (Imprime-OVA). Using T cell receptor transgenic OT-I CD8+ T cells to track responses to OVA, we treated mice with Imprime-OVA intravenously and examined the expansion and functional quality of the T cell response 7 days later at the peak of expansion. Following Imprime-OVA treatment, OVA-specific CD8 T cells underwent vigorous expansion, upregulated the transcription factor Tbet, which is central to developing effector functions, and gained the ability to produce the cytokines IFN-γ, TNF-α and IL-2. By comparison, OVA alone did not generate a functional CD8+ T cell response and instead induced anergy. To determine if cross-presenting DCs are required for CD8+ T cell activation, we used mice deficient in the transcription factor Batf3, which selectively eliminates CD8α+ cross-presenting DCs. Following treatment with the Imprime-OVA conjugate in these Batf3-/- mice, the expansion of OVA-specific CD8+ T cells was more than 10-fold reduced compared to that in wild-type mice. Further, these cells failed to develop effector functions, indicating that CD8α+ cross-presenting DCs are crucial for this response. Together, these data show that an Imprime PGG-protein conjugate can effectively elicit the expansion and functional activation of cytotoxic T cells and may have utility as a potential cancer vaccine platform. Citation Format: Ross B. Fulton, Steven Leonardo, Kyle Michel, Lindsay Wurst, Trinda Phelon, Mike Danielson, Keith Gorden. Imprime PGG conjugated directly to protein enables cross-presentation of antigen that generates multifunctional cytotoxic T cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-236. doi:10.1158/1538-7445.AM2015-LB-236
Electron transfer at the liquid-liquid interface between Lu(III) bisphtalocyanines in a solvent and Fe(III)/Fe(II) in water. Studies at a micro-interface and at solvent film electrodes (2003)

Conférence du 27 avril au 2 mai 2003. Communication orale.
Rapid pinealectomy in hamsters and other small rodents (1965)

Abstract Removal of the pineal organ from small rodents may be rapidly accomplished by (1) immobilizing the skull in a head mounting device and (2) by cutting and removing a circular disc of bone overlying the pineal area with the use of a dental machine and a specially designed circle cutter.
Alleged Changes in the Climate of Southern Turkistan: Discussion (1932)

William Goodenough, Francis Younghusband, L. V. S. Blacker, L. C. W. Bonacina, Reginald C. F. Schomberg, Professor Lyde, Alleged Changes in the Climate of Southern Turkistan: Discussion, The Geographical Journal, Vol. 80, No. 2 (Aug., 1932), pp. 140-144
A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript. (1987)

GCN4 encodes a transcriptional activator in Saccharomyces cerevisiae that is regulated at the translational level. We show that an approximately 240-nucleotide segment from the GCN4 mRNA leader containing four AUG codons is sufficient to confer translational control typical of GCN4 upon a GAL1-lacZ fusion transcript. Regulation of the hybrid transcript is dependent upon multiple positive (GCN) and negative (GCD) trans-acting factors shown to regulate GCN4 expression post-transcriptionally. This result limits the target sequences for these factors to a small internal segment of the GCN4 mRNA leader. The elimination of AUG codons within this segment substantially reduces the usual derepressing effect of mutations in five GCD genes upon GCN4-lacZ expression. This supports the idea that the products of these negative regulatory genes act by modulating the effects of the upstream AUG codons on translation of GCN4 mRNA.
Assessment of PDMS Technology in a MIMO Antenna Array (2015)

This letter assesses the use of a flexible multilayered polydimethylsiloxane (PDMS) substrate in a multiple-input- multiple-output (MIMO) antenna array for WLAN applications at 5.8 GHz. The use of the innovative polymer-based PDMS technology features favorable mechanical properties such as flexibility, water/dust resistance, and optical transparency. Besides that, PDMS also has a relatively low loss tangent. All these properties are very relevant for future (wearable) WLAN MIMO antennas. The proposed 2 × 4 antenna array and its rear ground plane are embedded in a multilayered PDMS substrate and fed by two 50Ω coaxial ports. It is found that the multilayered PDMS substrate may yield a design with excellent MIMO parameters. The mutual coupling is better than -30 dB, the envelope correlation coefficient (ρ) is in the order of 0.001, and the efficiency is 72%. A high gain of 11.5 dB is achieved.
Liquid chromatography of glycated hemobglobins with the Daiichi HA-8110 automated analyzer. (1984)

Journal Article Liquid chromatography of glycated hemobglobins with the Daiichi HA-8110 automated analyzer. Get access E P Diamandis, E P Diamandis Search for other works by this author on: Oxford Academic Google Scholar G Ellis, G Ellis Search for other works by this author on: Oxford Academic Google Scholar D Daneman, D Daneman Search for other works by this author on: Oxford Academic Google Scholar L C Allen L C Allen Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 30, Issue 3, 1 March 1984, Pages 503–504, https://doi.org/10.1093/clinchem/30.3.503 Published: 01 March 1984
Pseudaphelenchus yukiae n. gen., n. sp. (Tylenchina: Aphelenchoididae) associated with Cylindrotermes macrognathus (Termitidae: Termitinae) in La Selva, Costa Rica (2009)

Abstract A species of aphelenchoidid nematode was isolated from a subterranean termite, Cylindrotermes macrognathus, during a survey of termite-associated nematodes in a conserved forest in La Selva, Costa Rica. The nematode was morphologically intermediate between the families Aphelenchidae and Aphelenchoididae, i.e., the nematode had a true bursa supported by bursal limb-like genital papillae but lacked a clear pharyngeal isthmus. The molecular phylogenetic status of the new nematode among tylenchid, cephalobid, panagrolaimid, aphelenchid and aphelenchoidid genera was analysed based on ca 1.2 kb of SSU ribosomal DNA sequence and the inferred position was basal to the family Aphelenchoididae. It was clearly not part of the clade containing the genus Aphelenchus (=Aphelenchidae). This nematode is described herein as Pseudaphelenchus yukiae n. gen., n. sp., and the family definition of Aphelenchoididae is emended to include the unique morphological characters of this new genus. The molecular phylogenetic analysis supported the paraphyly of the three Aphelenchoidinae genera Aphelenchoides, Laimaphelenchus and Schistonchus and the monophyly of Ektaphelenchinae, Seinura (Seinurinae) and Noctuidonema (Acugutturinae). However, many more representatives are needed to resolve the family-genus level phylogeny of Aphelenchoididae.
Material analysis end-station of the Hyogo-ken beamline at SPring-8 (1998)

Plans to construct surface-analysis equipment which will be placed on beamline BL24XU of SPring-8 are presented. There are three experimental hutches in BL24XU, which are available simultaneously by using diamond monochromators as beam splitters. The purpose of the surface-analysis equipment is the simultaneous measurement of fluorescent and diffracted X-rays in grazing-incidence geometry. The instrument is equipped with a solid-state detector (SSD) and a flat position-sensitive proportional counter (PSPC) combined with analysing crystals for X-ray fluorescence (XRF) analysis. A curved PSPC and the goniometer that mounts the SSD used for XRF are also installed for X-ray diffraction. X-ray fluorescence holography and polarized X-ray emission spectroscopy modes are available, so three-dimensional images of atomic configurations and also the anisotropic structure of materials will be studied.
Imaging beneath complex layering: Processing seismic data with complex decomposition and renormalization group (2007)

Seismic Imaging beneath complex layering is challenging and problematic. Examples of complex layering are complex shale, carbonate, basalt and salt. Both the quality of the image and wavelet fidelity of the reservoir beneath the complex layering are usually not satisfactory below complex layering, largely because of the associated multiples and elastic waves. These effects interfere with the primary reflection. The problem is more acute for seismic reservoir analysis where agreement between observed logs data and seismic is important. Apache Corporation and WesternGeco undertook a Strategic Technology Alliance Project of a modeling study to investigate old and new seismic processing methodology. The purpose is to do an in‐depth analysis of assumptions and approximations in the conventional seismic processes. The study identifies which of these programs are ineffective in the presence of interference due to strong interaction in the overburden. Then we can replace these programs with the new processing programs like complex decomposition and renormalization group.
Arthroscopic Meniscectomy (1984)

Review of the records at the time of final office visits of one hundred and thirty-four patients who underwent arthroscopic subtotal meniscectomy and interview of one hundred and two of these patients three to four years after surgery revealed that symptoms related to disruption of the meniscus can be totally or significantly relieved in 99.3% of cases. Meniscal symptoms did not recur in the absence of reinjury three to four years later, despite the occasional presence of associated pathologic joint conditions. Arthroscopic meniscectomy has proved safe and effective, and it is associated with low postoperative morbidity and early return to function. Preservation of a peripheral rim of meniscus in contrast to total meniscectomy offers the theoretic advantages of preservation of some degree of joint stability and load distribution to diminish the risk of premature degenerative articular changes.
Direct mass spectrometric mixture analysis by negative chemical ionization/mass-analyzed ion kinetic energy spectrometry (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect mass spectrometric mixture analysis by negative chemical ionization/mass-analyzed ion kinetic energy spectrometryR. W. Kondrat, G. A. McClusky, and R. G. CooksCite this: Anal. Chem. 1978, 50, 8, 1222–1223Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ac50030a054https://doi.org/10.1021/ac50030a054research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cultivar Differences in Canopy Apparent Photosynthesis and Their Relationship to Seed Yield in Soybeans<sup>1</sup> (1982)

Differences in leaf photosynthesis among soybean [ Glycine max (L.) Merr.] genotypes have not been shown to be correlated with seed yield, probably because leaves selected for measurement have not been representative of the soybean canopy. In order to obtain a measure more representative of photosynthesis by plant communities and to explore the relationship of canopy apparent photosynthesis (CAP) to seed yield, field experiments were conducted during 2 years. Four soybean cultivars in each of four Maturity Groups (V through VIII) were grown in field plots in 1975 and two of each Maturity Group were grown in 1976. Measurements of CAP were made throughout the reproductive period by placing a large plastic covered chamber over a square meter segment of the canopy and measuring CO 2 depletion during a 1 to 2 min period. Measurements were made near noon when solar radiation was above 0.9 Ly/min. Maximum values of CAP were 4 to 6 g CO 2 m ‐ 2hr ‐1 during the early reproductive stages and decreased with age throughout pod filling. The decrease was most rapid for Maturity Group V and slowest for Group VIII. Dates when CAP dropped to zero were mid‐September for the Group V cultivars and mid‐October for Group VIII. Differences in CAP among cultivars occurred during seed development for all Maturity Groups. These differences could not be attributed to leaf area index or light interception since differences in CAP occurred while light interception was above 97%. Seed yield also differed among cultivars within Maturity Groups, the range in yield being from about 2,000 to 3,600 kg/ha in both years. Correlation coefficients for the association between yield and CAP measured during seed development were significant and ranged from 0.43 to 0.62. An integral of the CAP measurements from the full‐pod stage of development (R‐4) to maturity was correlated with yield with a coefficient of 0.66 in 1975 and 0.59 in 1976. Data from these experiments indicate that yield differences among cultivars are partially accounted for by differences in photosynthetic capacity of the plant canopy during seed development.
Building a Database to Support Intelligent Computational Quality Assurance of Resistance Spot Welding Joints (2007)

A database system for storing information on resistance spot welding processes is outlined. Data stored in the database can be used for computationally estimating the quality of spot welding joints and for adaptively setting up new welding processes in order to ensure consistent high quality. This is achieved by storing current and voltage signals in the database, extracting features out of those signals and using the features as training input for classifier algorithms. Together the database and the associated data mining modules form an adaptive system that improves its performance over time. An entity-relationship model of the application domain is presented and then converted into a concrete database design. Software interfaces for accessing the database are described and the utility of the database and the access interfaces as components of a welding quality assurance system is evaluated. A relational database with tables for storing test sets, welds, signals, features and metadata is found suitable for the purpose. The constructed database has served well as a repository for research data and is ready to be transferred to production use at a manufacturing site.
Cobalt‐Mediated Linear 2:1 Co‐oligomerization of Alkynes with Enol Ethers to Give 1‐Alkoxy‐1,3,5‐Trienes: A Missing Mode of Reactivity (2010)

A variety of 1,6-heptadiynes and certain borylalkynes co-oligomerize with enol ethers in the presence of [CpCo(C(2)H(4))(2)] (Cp=cyclopentadienyl) to furnish the hitherto elusive acyclic 2:1 products, 1,3,5-trien-1-ol ethers, in preference to or in competition with the alternative pathway that leads to the standard [2+2+2] cycloadducts, 5-alkoxy-1,3-cyclohexadienes. Minor variations, such as lengthening the diyne tether, cause reversion to the standard mechanism. The trienes, including synthetically potent borylated derivatives, are generated with excellent levels of chemo-, regio-, and diastereoselectivity, and are obtained directly by decomplexation of the crude mixtures during chromatography. The cyclohexadienes are isolated as the corresponding dehydroalkoxylated arenes. In one example, even ethene functions as a linear cotrimerization partner. The alkoxytrienes are thermally labile with respect to 6pi-electrocyclization-elimination to give the same arenes that are the products of cycloaddition. The latter, regardless of the mechanism of their formation, can be viewed as the result of a formal [2+2+2] cyclization of the starting alkynes with acetylene. One-pot conditions for the exclusive formation of arenes are developed. DFT computations indicate that cyclohexadiene and triene formation share a common intermediate, a cobaltacycloheptadiene, from which reductive elimination and beta-hydride elimination compete.
Ba<sub>4</sub>B<sub>8</sub>TeO<sub>19</sub>: A UV Nonlinear Optical Material (2018)

We report a new noncentrosymmetric barium tellurium borate, Ba<sub>4</sub>B<sub>8</sub>TeO<sub>19</sub> that has potential ultraviolet (UV) nonlinear optical (NLO) applications. Ba<sub>4</sub>B<sub>8</sub>TeO<sub>19</sub> was synthesized by a flux method and crystallizes in the noncentrosymmetric space group Cc. The material exhibits a framework structure of [B<sub>8</sub>O<sub>17</sub>]<sub>∞</sub> double layers connected to distorted TeO<sub>6</sub> octahedra. Second harmonic generation (SHG) measurements at 1064 and 532 nm on polycrystalline Ba<sub>4</sub>B<sub>8</sub>TeO<sub>19</sub> indicate that the title compound is phase-matchable (type I) with a moderate SHG response (1 × KH<sub>2</sub>PO<sub>4</sub> at 1064 nm and 0.2 × β-BaB<sub>2</sub>O<sub>4</sub> at 532 nm). In addition, a short absorption edge (210 nm) was measured. Using density functional theory calculations, we show that the SHG response originates from contributions from O 2p and Te 5s states at the valence and conduction band edges. Finally, by computing the linear optical properties, we find that this compound displays a moderate birefringence of 0.055 at 1064 nm and 0.059 at 532 nm, necessary conditions for phase-matching in UV NLO materials.
FDMO: Feature Assisted Direct Monocular Odometry (2018)

Visual Odometry (VO) can be categorized as being either direct or feature based. When the system is calibrated photometrically, and images are captured at high rates, direct methods have shown to outperform feature-based ones in terms of accuracy and processing time; they are also more robust to failure in feature-deprived environments. On the downside, Direct methods rely on heuristic motion models to seed the estimation of camera motion between frames; in the event that these models are violated (e.g., erratic motion), Direct methods easily fail. This paper proposes a novel system entitled FDMO (Feature assisted Direct Monocular Odometry), which complements the advantages of both direct and featured based techniques. FDMO bootstraps indirect feature tracking upon the sub-pixel accurate localized direct keyframes only when failure modes (e.g., large baselines) of direct tracking occur. Control returns back to direct odometry when these conditions are no longer violated. Efficiencies are introduced to help FDMO perform in real time. FDMO shows significant drift (alignment, rotation & scale) reduction when compared to DSO & ORB SLAM when evaluated using the TumMono and EuroC datasets.
Detection of luxol-fast-blue positive cells in human promyelocytic leukemia cell line HL-60. (1981)

Differentiation of HL-60 cells toward the eosinophilic series has not been reported previously. Eosinophil granule specific staining with Luxol-fast-blue was used to determine if HL-60 cells could differentiate into the eosinophilic lineage. The specificity of the Luxol-fast-blue stain for cells of the eosinophilic series was substantiated by comparison of the staining of cells from a patient with an eosinophilic syndrome by Wright-Giemsa and Luxol-fast-blue. Luxol-fast-blue positivity was most notable in cells found in colonies formed from HL-60 clonogenic cells in semisolid agar medium. Colony and cluster formation was spontaneous but in the presence of medium conditioned by either human placental cells or the human monocyte-like cell line, GCT, Luxol-fast-blue positive colonies and clusters were detected at a higher frequency.
ChemInform Abstract: CARBOXYLIC N,N‐DIPHENYLCARBAMIC ANHYDRIDES. NEW ACYLATING AGENTS (1979)

Abstract Aus der Carbonsäure (I) erhält man z.B. mit N,N‐Diphenylcarbamoylchlorid und einem Amin oder 1‐(N,N‐Diphenylcarbamoyl)‐pyridinium‐chlorid (VI) das gemischteAnhydrid (II), das mit Methanol in den Ester (III) übergeht.
A Functioning Chimera of the Cyclic Nucleotide-Binding Domain from the Bovine Retinal Rod Ion Channel and the DNA-Binding Domain from Catabolite Gene-Activating Protein (2001)

The eukaryotic cyclic nucleotide-gated (CNG) ion channels are a family of large membrane proteins activated by cytoplasmic cGMP or cAMP. Their cyclic nucleotide-binding domain is structurally homologous with that of the catabolite gene-activator protein (CAP), a soluble Escherichia coli transcription factor. Differences in ligand activation among sensory channels suggest differences in the underlying molecular mechanisms of signal readout. To study the structural, functional, and conformational consequences of nucleotide binding, we fused the cyclic nucleotide-binding domain from the bovine retinal rod CNG channel alpha subunit (Bralpha) to the DNA-binding domain from CAP. The chimera forms a soluble dimer that binds both cGMP and cAMP with association constants of 3.7 x 10(4) M(-1) for [(3)H]cGMP and 3.1 x 10(4) M(-1) for [(3)H]cAMP. The binding of cAMP, but not cGMP, exposes a chymotrypsin cleavage site in the chimera at a position similar to the site in the CAP exposed by cAMP binding. At high cAMP concentrations, a biphasic pattern of cleavage is seen, suggesting that the low-affinity cAMP binding sites are also occupied. Cyclic AMP promotes specific binding to a DNA fragment encoding the lac operator region; the K(d) for the protein-DNA binding is approximately 200 nM, which is 2-fold higher than the K(d) for CAP under identical conditions. A 7 A crystal structure shows that the overall secondary and tertiary structure of Bralpha/CAP is the same as that of CAP with two cAMP molecules bound per dimer. The biochemical characterization of the chimera suggests it will be a useful system for testing hypotheses about channel activation, providing further insight into channel function.