gebhart/patrepeval huggingface dataset:
H2S and HS– donor NaHS inhibits intracellular chloride channels (2009)

We have characterized the effect of H(2)S on single channel properties of the chloride channels derived from the rat heart lysosomal vesicles incorporated into a bilayer lipid membrane. The single chloride channel currents were measured in 250 : 50 mmol/l KCl cis/trans solutions. H(2)S inhibited the chloride channels by decreasing the channel open probability in a concentration-dependent manner. The inhibitory effect of H(2)S was side-dependent with the IC(50) values of 42 and 75 micromol/l for the trans and the cis sides, respectively. The mixture of H2S with the NO donor S-nitroso-N-acetyl-DL-penicillamine had smaller effect (IC(50) = 180 micromol/l) than H(2)S alone. We assume that the inhibitory effect of H(2)S on chloride channels may be responsible for some of its numerous biological effects.
Phosphorus Nanoparticles Encapsulated in Graphene Scrolls as a High‐Performance Anode for Sodium‐Ion Batteries (2015)

Abstract Two composites of phosphorus nanoparticles encapsulated in graphene scrolls (P‐G) and phosphorus nanoparticles loaded on planar graphene sheets (P/G) were successfully prepared and applied as anodes for sodium‐ion batteries. Phosphorus nanoparticles (ca. 100–150 nm) were firstly obtained from commercial red phosphorus by using a simple flotation method. P‐G composites with different phosphorus contents (38.6, 52.2, and 62.1 %) were synthesized through a quick‐freezing process. In addition, the P/G composite with a phosphorus content of 50.8 % was prepared for comparison purposes. As a result, the P‐G composites showed a better performance than the P/G composite. Moreover, the P‐G composite with a phosphorus content of 52.2 % showed the best performance, delivering a capacity of 2355 mAh g −1 in the second cycle and 2172 mAh g −1 after 150 cycles at 250 mA g −1 (with a capacity retention of 92.3 %).
Is there a case for cisplatin in the treatment of small-cell lung cancer? A meta-analysis of randomized trials of a cisplatin-containing regimen versus a regimen without this alkylating agent (2000)

Chemotherapy is the backbone of small-cell lung cancer therapy. However, optimal drug combinations and schedules remain to be defined and there is hitherto no world-wide accepted standard regimen. Cisplatin, an alkylating agent with high putative toxicity is currently widely used although its effectiveness in this disease has not been established firmly. We conducted a meta-analysis of published data reporting trials randomizing a cisplatin-containing regimen versus a regimen without this alkylating agent in order to determine possible differences in survival response and toxicity. Nineteen trials have been identified in medical literature (4054 evaluable patients). Ten trials randomized patients to receive a cisplatin-etoposide regimen versus a regimen without any of these two drugs. A subgroup analysis was, therefore, carried out in the nine remaining trials that randomly allocated patients between two regimens differing in the absence or presence of cisplatin, whereas etoposide was given (or not given) in both arms (1579 evaluable patients). The DerSimonian and Laird method was used to estimate the size effects and the Peto and Yusuf method was used in order to generate the odds ratios (OR) of reduction in risk of death and the increase in probability of being responders to chemotherapy. There was no significant difference between the cisplatin-containing regimen and the regimen without this drug when the risk of toxic-death was taken into account with respective probabilities of 3.1 and 2.7% (NS). Patients randomized in a cisplatin-containing regimen had an increase in probability of being responders with an OR of 1.35, 95% confidence interval (CI) of 1.18-1.55; P < 10(-5) corresponding to an increase of objective (partial plus complete) response rate from 0.62 to 0.69 (a result taking into account a significant heterogeneity). Patients treated with a cisplatin-containing regimen benefited from a significant reduction of risk of death at 6 months and 1 year with respective OR 0.87, 95% CI 0.75-0.98, P = 0.03, and or 0.80, 95% CI 0.69-0.93, P = 0.002 (no statistical heterogeneity). This corresponded to a significant increase in the probability of survival of 2.6% and 4.4% at 6 months and 1 year respectively. The meta-analysis restricted to the subset of nine trials without etoposide treatment imbalance reached similar conclusions. A cisplatin-containing regimen yields a higher response rate and probability of survival than does a chemotherapy containing others alkylating agents without a perceptible increase in risk of toxic-death.
Python como primera aproximación a la programación (2015)

Se analiza la adecuacion del lenguaje Python a la docencia de primer curso de programacion para estudiantes de Ingenieria Informatica, detectando escollos clasicos del primer acercamiento a la programacion, que potencialmente resuelve y nuevos con que potencialmente tropezaran los alumnos.
Application of Ammonium α-Allyl Alkyl Phenol Polyoxyethylene Ether Sulfonate in Acrylic Emulsion Pressure-Sensitive Adhesive (2011)

Three acrylic pressure-sensitive adhesives with same composition but emulsified by different surfactants were prepared. The test results showed that adhesion properties and water resistance of the adhesives emulsified by polymerizable surfactant were better than those of conventional ones. In addition, surface tension and contact angle of adhesive based on polymerizable surfactant were higher than the conventional ones. These differences were attributed to the different migration abilities of the surfactants, as explained with atomic force microscopy images. Furthermore, the storage modulus of the adhesive can be enhanced by the reaction of polymerizable surfactant, which was conformed by dynamic mechanic analysis.
Operation of the SAGE duplex computers (1958)

Large scale digital computers perform the routine control and data-processing functions of SAGE direction centers. For practical air defense, the SAGE direction centers must operate around the clock, a goal not yet achieved by present-day computing equipment. In order to achieve 24-hour-per-day operation, two identical computers are provided at each center. One computer (the active computer) operates the direction-center program. The other computer (the stand-by computer) is available for preventive maintenance and a limited amount of routine data processing. The functions of the two machines are interchanged by switching the direction-center inputs and outputs from one machine to the other. Thus, if the active computer fails, the task of operating the direction-center program can be transferred to the stand-by machine, and as far as the direction center is concerned, computer down time is reduced to those periods when both machines are simultaneously inoperative.
Predicting defect-tolerant yield in the embedded core context (2003)

We address the problem of predicting the yield of a chip composed of cores. A center-satellite model is used to directly represent observed spatial autocorrelation of integrated circuit spot defects. This model is compared to another (large-area clustering) model that only indirectly represents intrawafer correlation. We illustrate that, when different portions of a chip have different susceptibility to defects, the chip layout will affect the predicted yield. This is particularly relevant when portions of a chip are defect-tolerant because their susceptibility to defects is dramatically different. We illustrate how the yield models can be used to predict the utility of making much of a chip (or an embedded core) defect-tolerant. Two yield points parameterized the models. The one extra parameter of, and the suitability of, the center-satellite model allowed it to track the yield data points with less than 1 /10,000 of the error of the large-area clustering model. However, the simpler large-area clustering model is accurate in some circumstances, especially when the chip area is small.
Topics on Drug Metabolism (2012)

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.
Genome size of Streptomyces (1984)

The genome sizes of 13 Streptomyces and 2 Streptoverticillium strains were determined by the initial renaturation rate method described by De Ley and Gillis. The estimated genome sizes are within the range of 3.69 · 109 Da to 5.15 · 109 Da.
<i>I</i> <i>n</i> <i>s</i> <i>i</i> <i>t</i> <i>u</i> arsenic doping of epitaxial silicon at 800 °C by plasma enhanced chemical vapor deposition (1987)

A comparison of in situ arsenic doping of epitaxial silicon films deposited at 800 °C by both very low pressure chemical vapor deposition (CVD) and plasma enhanced chemical vapor deposition (PECVD) is presented. The growth rate and morphology of films deposited by CVD are degraded in the presence of arsine. PECVD growth rates are insensitive to arsine. Moreover, PECVD deposits show an order of magnitude increase in active dopant incorporation and exhibit superior morphology relative to CVD.
Effects of Dental Probing on Occlusal Surfaces – A Scanning Electron Microscopy Evaluation (2006)

The aim of this clinical-morphological study was to investigate the effects of dental probing on occlusal surfaces by scanning electron microscopy (SEM). Twenty sound occlusal surfaces of third molars and 20 teeth with initial carious lesions of 17- to 26-year-old patients (n = 18) were involved. Ten molars of each group were probed with a sharp dental probe (No. 23) before extraction; the other molars served as negative controls. After extraction of the teeth, the crowns were separated and prepared for the SEM study. Probing-related surface defects, enlargements and break-offs of occlusal pits and fissures were observed on all occlusal surfaces with initial carious lesions and on 2 sound surfaces, respectively. No traumatic defects whatsoever were visible on unprobed occlusal surfaces. This investigation confirms findings of light-microscopic studies that using a sharp dental probe for occlusal caries detection causes enamel defects. Therefore, dental probing should be considered as an inappropriate procedure and should be replaced by a meticulous visual inspection. Critical views of tactile caries detection methods with a sharp dental probe as a diagnostic tool seem to be inevitable in undergraduate and postgraduate dental education programmes.
Case 37-2010 (2010)

A 16-year-old girl with a history of lupus nephritis was seen in the emergency department because of altered mental status. She was somnolent and agitated and had no focal neurologic signs. Brain CT revealed no abnormalities. Laboratory studies revealed anemia and thrombocytopenia.
OmpL1 DNA vaccine cross-protects against heterologous Leptospira spp. challenge. (2007)

Available leptospirosis vaccines made up of inactivated bacteria or their membrane components elicit immunity which is serovar specific and unsatisfactory immunological memory. A vaccine that protects across Leptospira serogroups/serovars, i.e. broad spectrum, and induces long-lasting memory is needed for both human and veterinary uses. In this study, a plasmid DNA vaccine was constructed from cloning gene encoding a transmembrane porin protein, OmpL1, of pathogenic Leptospira interrogans, serogroup Icterohaemorrhagiae, serovar Copenhageni into a mammalian expression vector pcDNA3.1(+). The protective efficacy of the ompL1-pcDNA3.1(+) plasmid DNA vaccine was studied by immunizing hamsters intramuscularly with three doses of the vaccine (100 microg per dose) at two week intervals. The empty pcDNA3.1(+) and PBS were used as mock as negative vaccine controls, respectively. All animals were challenged with the heterologous Leptospira interrogans, serogroup Pomona, serovar Pomona (10 LD50), at one week after the last vaccine booster. The ompL1-pcDNA3.1(+) plasmid DNA vaccine rescued some vaccinated animals from the lethal challenge and delayed death time, reduced morbidity, e.g. fever, and/or the numbers of Leptospira in the tissues of the vaccinated animals. While the results are encouraging, further studies are needed to optimize the immunization schedule, vaccine dosage and formulation in order to maximize the efficacy of the vaccine.
Brain Perfusion in Encephalopathic Newborns after Therapeutic Hypothermia (2013)

Disturbed cerebral perfusion is observed in the second week of life in some babies with HIE despite treatment with hypothermia. Infants with HIE with injury on MR imaging have lower regional CBF in the thalamus compared with those without injury, possibly representing pseudonormalization of CBF and low metabolic demand after progression to irreversible brain injury.
An Electronic Analyzer for Diesel Engines (1969)

<div class="htmlview paragraph">An analyzer for diesel engines has been developed which enables rapid diagnosis of the injection system. This electronic device uses calibrated quartz pressure transducers to measure the instantaneous pressure in each injection line. The pressure signal from the first cylinder is used to produce synchronization with crankshaft rotation. The trace for each injection line is then displayed on a conventional cathode ray engine analyzer. The instrument also contains circuitry which gives precise measurement of nozzle static opening pressure, and timing and timing advance at various speeds.</div>
‘Hardcore’ OX40<sup>+</sup>immunosuppressive regulatory T cells in hepatic cirrhosis and cancer (2014)

Human regulatory T cells (Tregs) comprise an array of distinct subsets displaying diverse functions in response to microenvironmental signals. Here, we review our recent findings demonstrating the preferential accumulation of uncommitted, Th1-like and OX40<sup>-</sup> Tregs in non-cirrhotic tissues in contrast to the presence of committed, Th1-suppressing and OX40<sup>+</sup> Tregs in cirrhotic and tumor contexts in human liver affected by chronic hepatitis C.
<b>Galvinoxyl (2,6-Di-<b><i>tert</i></b>-butyl-α-(3,5-di-<b><i>tert</i></b>-butyl-4-oxo-2,5-cyclohexadiene-1-ylidene)-<b><i>p</i></b>-tolyloxy) as a Scavenger of Shorter-lived Free Radicals</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGalvinoxyl (2,6-Di-tert-butyl-α-(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadiene-1-ylidene)-p-tolyloxy) as a Scavenger of Shorter-lived Free RadicalsPaul D. Bartlett and Toshio. FunahashiCite this: J. Am. Chem. Soc. 1962, 84, 13, 2596–2601Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/ja00872a026https://doi.org/10.1021/ja00872a026research-articleACS PublicationsRequest reuse permissionsArticle Views807Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sigma: Strain-level inference of genomes from metagenomic analysis for biosurveillance (2014)

Supplementary data are available at Bioinformatics online.
Separation of liquid mixtures by using polymer membranes. I. Water–alcohol separation by pervaporation through PVA‐<i>g</i>‐MMA/MA membrane (1991)

Abstract A membrane was designed for the separation of a water–alcohol mixture by pervaporation on the basis of the difference in hydrogen‐bonding interaction between two components of the membrane. Two kinds of poly(vinyl alcohol)‐ g ‐maleic anhydride/methyl methacrylate membrane were prepared by different methods: (1) A homogeneous membrane was formed by casting from dimethyl sulfoxide solution after purification. (2) A porous membrane was obtained directly by casting from the reaction solution, and then was purified. It is found that water was permeated through a homogeneous membrane preferentially in all ranges of feed compositions. Moreover, the flux was found to decrease with increasing PVA content in the membrane. The porous membrane after heat treatment has selective permeability for methanol. Pervaporation of water was investigated with respect to the feed concentration and also to the operating conditions. The effect of the molecular size of the permeating species on both permeation and separation is also discussed.
How to treat transmission line effects when testing high speed devices with a high performance test system (2003)

State-of-the-art digital ASICs have even faster clock rates and signal transition times; testing these devices may cause problems regarding delivering the signals to the device under test (DUT) and precisely measuring the response of the DUT. Transmission-line techniques have to be applied to the tester-to-DUT interconnection in order to maintain signal fidelity. The author illustrates how to implement this critical signal path in a high-speed test system to get high-precision timing and level measurements, particularly for CMOS devices. The solution suggested to embed a CMOS device in a transmission-line environment is the resistive divider. The operating principle of the resistive divider is to apply a definable DC load to the DUT. This maintains signal fidelity, as the signal is fed into a parallel terminated system. Therefore no reflections occur.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A review of: “<i>Simulation of Manufacturing Systems</i>”. By ALLAN CARRIE (John Wiley & Sons, 1988) [Pp. 418.] £29·95. Scope: text book. Level: introductory. (1989)

Abstract
BROADWAY: A World Wide Web Browsing Advisor Reusing Past Navigations from a Group of Users (1998)

: The World Wide Web is a huge hypermedia where finding relevant documents is not an easy task. In this paper, we present our case-based browsing advisor, called BROADWAY. BROADWAY follows a group of users during their navigations on the WWW (proxy-based architecture) and advise them by displaying a list of potentially relevant documents to visit next. BROADWAY uses case-based reasoning to reuse precise experiences derived from past navigations with a time-extended situation assessment: the advice are based mainly on similarity of ordered sequence of past accessed documents. In addition, the dynamic of the WWW is addressed in the reuse step and with a specific method for case forgetting. 1. Introduction The World Wide Web (WWW) [14] is an hypermedia of heterogeneous and dynamic documents. This virtual space is growing more and more every day, offering to the user a huge amount of data [3]. Two kinds of methods can be used to locate a relevant document through this space: querying and...
Ribonuclease P Catalysis Differs from Ribosomal RNA Self-Splicing (1985)

Two RNA-catalyzed reactions have been described, the Tetrahymena self-splicing ribosomal RNA and ribonuclease P. The Tetrahymena self-splicing reaction proceeds through a transesterification cascade that is dependent upon nucleophilic attacks by ribose 3'-OH groups. Periodate oxidation of the catalytic (or substrate) RNA, which destroys the nucleophilicity of RNA 3' termini, did not inhibit ribonuclease P activity. Thus, catalysis by ribonuclease P differs from the self-splicing reaction.
Intensive speech and language therapy for older children with cerebral palsy: a systems approach (2009)

Therapy was associated with increases in speech intelligibility. Effects of the therapy should be investigated further, in an exploratory trial with younger children and in a randomized controlled trial.
Exemplar-Based Image Inpainting Using Color Distribution Analysis (2012)

This paper proposes a novel exemplar-based inpianting algorithm based upon the color distribution analysis. A novel priority scheme is designed to assign priority and guide the filling-in order, which is a crucial step for the performance of the inpainted results. Color distribution is proposed to determine the confidence of the target patches situated on the boundary of the missing region by measuring the variation of variances of neighboring source patches. Our experiments on the natural images and the comparisons with the representative existing approaches show that our proposed scheme can more robustly assign high priority to the structures and enables the salient structures, to which human visual system is sensitive, to be consistent with the surrounding regions.
[Treatment using traditional acupuncture of early scapulohumeral pains following heart surgery]. (1991)

The purpose of this study was to test the efficacy of traditional Chinese acupuncture in the treatment of scapulohumeral pain during the early stage following heart surgery, by puncture of points not related anatomically or metamerically with the scapulohumeral joint and without any needle stimulation. Reduction of pain and angular gain were almost immediate, durable, measurable and reproducible, which could be explained by possible effects of acupuncture on articular sympathetic mechanoreceptors, then suppressing reflex muscular contractions due to intraoperative postural constraints.