gebhart/patrepeval huggingface dataset:
On the impact of uncorrelated variation in regression mathematics (2008)

Abstract The objective of the present study is to investigate if, and if so, how uncorrelated variation relates to regression mathematics as exemplified by partial least squares (PLS) methodology. In contrast to previous methods, orthogonal partial least squares (OPLS) method requires a multi‐focus, in the sense that in parallel to calculation of correlation it requires an analysis of orthogonal variation, i.e. the uncorrelated structure in a comprehensive way. Subsequent to the estimation of the correlation is the remaining orthogonal variation, i.e. uncorrelated data, divided into uncorrelated structure and stochastic noise by the ‘OPLS component’. Thus, it appears obvious that it is of interest to understand how the uncorrelated variation can influence the interpretation of the regression model. We have scrutinized three examples that pinpoint additional value from OPLS regarding the modelling of the orthogonal, i.e. uncorrelated, variation in regression mathematics. In agreement with the results, we conclude that uncorrelated variations do impact interpretations of regression analyses output and provides not only opportunities by OPLS but also an obligation for the user to maximize benefit from OPLS. Copyright © 2008 John Wiley & Sons, Ltd.
Coherent optical correlation: A new method of cranial comparison (1979)

In this paper an analog method known as coherent optical correlation is used to compare photographs of cercopithecine monkey skulls. Each comparison yields a measure of overall similarity in three-dimensional shape because the photographs are coded to preserve depth information. The coding system involves projecting an array of circular dots onto each specimen with an ordinary 35-mm slide projector. Photographs of the array taken from one side of the projector make ideal inputs for optical correlation analysis. Preliminary results indicate a reasonable ability to discriminate between different cercopithecine monkey skulls. This finding encourages further development of the proposed method as a shape investigation tool. Possibilities for application exist in many skeletal and somatological problems of form.
Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction (2016)

Mitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as the sarcoplasmic reticulum (SR). Inhibiting mitochondrial fission can protect the heart against acute ischemia/reperfusion (I/R) injury. However, the role of the mitochondrial fusion proteins, Mfn1 and Mfn2, in the response of the adult heart to acute I/R injury is not clear, and is investigated in this study. To determine the effect of combined Mfn1/Mfn2 ablation on the susceptibility to acute myocardial I/R injury, cardiac-specific ablation of both Mfn1 and Mfn2 (DKO) was initiated in mice aged 4-6 weeks, leading to knockout of both these proteins in 8-10-week-old animals. This resulted in fragmented mitochondria (electron microscopy), decreased mitochondrial respiratory function (respirometry), and impaired myocardial contractile function (echocardiography). In DKO mice subjected to in vivo regional myocardial ischemia (30 min) followed by 24 h reperfusion, myocardial infarct size (IS, expressed as a % of the area-at-risk) was reduced by 46% compared with wild-type (WT) hearts. In addition, mitochondria from DKO animals had decreased MPTP opening susceptibility (assessed by Ca(2+)-induced mitochondrial swelling), compared with WT hearts. Mfn2 is a key mediator of mitochondrial/SR tethering, and accordingly, the loss of Mfn2 in DKO hearts reduced the number of interactions measured between these organelles (quantified by proximal ligation assay), attenuated mitochondrial calcium overload (Rhod2 confocal microscopy), and decreased reactive oxygen species production (DCF confocal microscopy) in response to acute I/R injury. No differences in isolated mitochondrial ROS emissions (Amplex Red) were detected in response to Ca(2+) and Antimycin A, further implicating disruption of mitochondria/SR tethering as the protective mechanism. In summary, despite apparent mitochondrial dysfunction, hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction due to impaired mitochondria/SR tethering.
[Adenocarcinoma of the small intestine. A case report and the clinico-therapeutic considerations]. (1994)

Adenocarcinoma of the small bowel is a rare tumor. The diagnosis is often tardy and surgical treatment is still palliative in most cases. A major interest toward this kind of tumor as well as an early diagnosis may give the opportunity to perform a radical operation allowing better results in terms of survival.
Fibrillatory Conduction and Exit Block in the Pulmonary Veins. Two Mechanisms Seldom Seen During Catheter Ablation of Paroxysmal Atrial Fibrillation (2014)

Conduccion fibrilatoria y bloqueo de salida de las venas pulmonares. Dos mecanismos pocas veces objetivados durante la ablacion de la fibrilacion auricular paroxistica.
Regioselective Nitration of 1‐Acyl‐4‐methoxyindolines Leads to Efficient Synthesis of a Photolabile L‐Glutamate Precursor. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Noise-Robust Dual Filter Approach To Multichannel Blind System Identification (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007
ChemInform Abstract: FOUR‐CO‐ORDINATE CATIONIC DICARBONYL(PHOSPHINE)IRIDIUM(I) COMPLEXES OBTAINED FROM CHLOROTRICARBONYLIRIDIUM (1973)

Abstract Chlorotricarbonyl‐Ir(I) reagiert in äthanolischer Lösung in Gegenwart von Agtetrafluoroborat mit tert. Phosphinen zu" den trans‐Komplexen (II).
A METHOD OF EVALUATING GRADINGS OF CONCRETE AGGREGATES (1961)

Abstract not available
Stable Isotope Dilution Assays of Alternariol and Alternariol Monomethyl Ether in Beverages (2009)

Stable isotope dilution assays (SIDAs) for the determination of the most important mycotoxins of the black mold Alternaria, namely, alternariol and alternariol monomethyl ether, have been developed. For this purpose, deuterated alternariol and alternariol methyl ether were synthesized by palladium catalyzed protium-deuterium exchange from the unlabeled toxins. Reaction conditions were chosen in such a manner that the formation of the [(2)H(4)]-isotopologues was favored. The synthesized products were characterized by LC-MS, NMR, and UV-spectroscopy. On the basis of the use of [(2)H(4)]-alternariol and [(2)H(4)]-alternariol methyl ether as internal standards, SIDAs were developed and applied to the determination of alternariol and alternariol methyl ether in beverages using LC-MS/MS. Method validation revealed a high sensitivity, i.e., low limits of detection (alternariol, 0.03 microg/kg; alternariol methyl ether, 0.01 microg/kg) and limits of quantitation (alternariol, 0.09 microg/kg; alternariol methyl ether, 0.03 microg/kg), respectively. Recovery from spiked apple juice was 100.5 +/- 3.4% for alternariol (range 0.1-1 microg/kg) and 107.3 +/- 1.6% for alternariol methyl ether (range 0.05-0.5 microg/kg). Interassay precision (expressed as coefficient of variation, CEV) for alternariol was 4.0% (7.82 +/- 0.31 microg/kg; vegetable juice, naturally contaminated) and 4.6% (1.04 +/- 0.05 microg/kg; grape juice, naturally contaminated). For alternariol methyl ether, a CEV of 2.3% (0.79 +/- 0.02 microg/kg; vegetable juice, naturally contaminated) was obtained. Analysis of fruit juices showed low contamination with alternariol and alternariol methyl ether in general, but higher values of both toxins were found in wine and vegetable juices. The values for alternariol were higher than those for alternariol methyl ether in nearly any case. However, the developed SIDA has proven to be optimally suited for further studies on alternariol and alternariol methyl ether content in food samples to obtain further insight into possible health hazards for the consumer.
Mutual deterioration of WDM-coupled AM-CATV and digital B-ISDN services in single fiber access networks (1993)

In single-fiber access networks with interactive and distributive services multiplexed at different wavelengths, the interactive signal may disturb the distributive signal, and vice versa, because of imperfect isolation of the demultiplexing WDM at the subscriber site. The mutual deterioration of a 622-Mb/s intensity-modulated (IM) broadband ISDN (B-ISDN) signal at 1.3 mu m and an AM subcarrier-multiplexed (SCM) TV-distribution signal at 1.55 mu m is investigated. Both theory and experiment show that the isolation of the demultiplexing WDM must keep the undesirable 1.3- mu m, 622-Mb/s IM signal power on the analog receiver below -36 dBm to avoid degradation of the analog system CNR of 47 dB by more than 1 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Malnutrition on dialysis: the end of a fatality]. (2006)

Protein-energy malnutrition in patients treated with haemodialysis (HD) is a complex, multifactorial and prevalent problem, starting well ahead of the dialysis program. It is associated with an increased morbidity and mortality. Uraemic patients are relatively resistant to nutrients because of metabolism abnormalities. Prevention of malnutrition is therefore more efficient than treatment per se. Classical supplementation including oral nutritional supplements, intradialytic parenteral nutrition and enteral nutrition remain efficient, if applied for a sufficient time. A global approach coupling supplementation and strategies designed to optimise metabolism abnormalities should increase treatment efficacy and improve the outcome and quality of life of these patients.
An Osteopontin-Integrin Interaction Plays a Critical Role in Directing Adipogenesis and Osteogenesis by Mesenchymal Stem Cells (2013)

An imbalance between normal adipogenesis and osteogenesis by mesenchymal stem cells (MSCs) has been shown to be related to various human metabolic diseases, such as obesity and osteoporosis; however, the underlying mechanisms remain elusive. We found that the interaction between osteopontin (OPN), an arginine-glycine-aspartate-containing glycoprotein, and integrin αv/β1 plays a critical role in the lineage determination of MSCs. Although OPN is a well-established marker during osteogenesis, its role in MSC differentiation is still unknown. Our study reveals that blockade of OPN function promoted robust adipogenic differentiation, while inhibiting osteogenic differentiation. Re-expression of OPN restored a normal balance between adipogenesis and osteogenesis in OPN(-/-) MSCs. Retarded bone formation by OPN(-/-) MSCs was also verified by in vivo implantation with hydroxyapatite-tricalcium phosphate, a bone-forming matrix. The role of extracellular OPN in MSC differentiation was further demonstrated by supplementation and neutralization of OPN. Blocking well-known OPN receptors integrin αv/β1 but not CD44 also affected MSC differentiation. Further studies revealed that OPN inhibits the C/EBPs signaling pathway through integrin αv/β1. Consistent with these in vitro results, OPN(-/-) mice had a higher fat to total body weight ratio than did wild-type mice. Therefore, our study demonstrates a novel role for OPN-integrin αv/β1 in regulating MSC differentiation.
Oxidative Stress Induced Inflammation Initiates Functional Decline of Tear Production (2012)

Oxidative damage and inflammation are proposed to be involved in an age-related functional decline of exocrine glands. However, the molecular mechanism of how oxidative stress affects the secretory function of exocrine glands is unclear. We developed a novel mev-1 conditional transgenic mouse model (Tet-mev-1) using a modified tetracycline system (Tet-On/Off system). This mouse model demonstrated decreased tear production with morphological changes including leukocytic infiltration and fibrosis. We found that the mev-1 gene encodes Cyt-1, which is the cytochrome b(560) large subunit of succinate-ubiquinone oxidoreductase in complex II of mitochondria (homologous to succinate dehydrogenase C subunit (SDHC) in humans). The mev-1 gene induced excessive oxidative stress associated with ocular surface epithelial damage and a decrease in protein and aqueous secretory function. This new model provides evidence that mitochondrial oxidative damage in the lacrimal gland induces lacrimal dysfunction resulting in dry eye disease. Tear volume in Tet-mev-1 mice was lower than in wild type mice and histopathological analyses showed the hallmarks of lacrimal gland inflammation by intense mononuclear leukocytic infiltration and fibrosis in the lacrimal gland of Tet-mev-1 mice. These findings strongly suggest that oxidative stress can be a causative factor for the development of dry eye disease.
Destruction of cyclotron resonances in weakly collisional, inhomogeneous plasmas (1979)

It is shown, both analytically and numerically, that cyclotron resonances can be destroyed in dense (ωp≳Ω, where ωp is the plasma frequency and Ω is the cyclotron frequency), weakly collisional, inhomogeneous plasmas when (ν/Ω) k2r2L≳1, where ν is the collision frequency and rL is the mean Larmor radius. The theory is based upon a model Fokker–Planck equation. It is found that the particles make a transition from magnetized to unmagnetized behavior. This is an important result since it indicates that the ion-and electron-cyclotron-drift instabilities transform into their unmagnetized counterparts, the lower-hybrid-drift instability and the ion-acoustic instability, respectively. The ion-cyclotron-drift (or drift-cyclotron instability) is examined in detail and is found to become the lower-hybrid-drift instability in the region of maximum growth when (me/mi)1/2ω/Ωi≳νii/ Ωi ≳me/mi for Te≈Ti plasmas. The first inequality is required to overcome electron viscuous damping, while the second allows the ions to become ’’unmagnetized.’’ Applications to the equatorial F region of the ionosphere and the tandem mirror experiment (TMX) are discussed.
Development of New Corrosion Inhibitor to Prevent Black Powder Formation Using Quartz Crystal Microbalance Technique (2011)

Abstract Black powder formation is an oxidative corrosion process that over time can cause operational problems as the solids collect within the system. There is a net weight gain within the system as molecular oxygen becomes incorporated as part of the solid materials. A novel quartz crystal microbalance (QCM) test apparatus has been developed to determine the effectiveness of various corrosion inhibitors to prevent black powder formation in sales gas pipelines. The QCM measures minute changes in frequency of a quartz crystal with weight gain/loss. For our test apparatus, the QCM crystal was coated with iron where small increases in mass due to oxidation of the iron layer are recorded as a drop in frequency. Using the Sauerbrey equation, the drop in frequency observed during corrosion testing can be converted to a corrosion rate. Several inhibitor chemistries were tested using the QCM apparatus. In this study it was found that a new oil-soluble corrosion inhibitor is the most effective for preventing black powder formation under the sales gas conditions.
ChemInform Abstract: A New Class of Amino Acid Based Sweeteners. (1986)

Abstract Die L‐Asparaginsäurederivate (IV), welche nach Hofmann‐Abbau der Amide (I) und Acylierung der Salze (II) erhalten werden, sind hydrolytisch außerordentlich stabil.
Effect of errors to a laser‐speckle strain gauge (2007)

This paper proposes a new arrangement for an interferometric laser‐speckle gauge. For the proposed set‐up geometrical inaccuracies are assumed. Therefore, we are looking for a sensor position, where the geometrical inaccuracies are having the smallest impact on the measurement result. For the measurement of an applied measurand vector to the observed specimen, we suggest a linear unbiased minimum variance estimator. Theory an measurement results using this estimator are shown for a specific measurement set‐up of the laser‐speckle strain gauge.
Metabolism of Endogenous Nos Inhibitors Lowers Blood Pressure and Regulates Nitric Oxide Synthesis following Hindlimb Ischaemia (2002)

Conference Abstract| July 01 2002 Metabolism of Endogenous Nos Inhibitors Lowers Blood Pressure and Regulates Nitric Oxide Synthesis following Hindlimb Ischaemia V Achan; V Achan 1University College London, UK2 Stanford University School of Medicine, USA Search for other works by this author on: This Site PubMed Google Scholar M Stuehlinger; M Stuehlinger 2 Stanford University School of Medicine, USA Search for other works by this author on: This Site PubMed Google Scholar S Adimoolam; S Adimoolam 2 Stanford University School of Medicine, USA Search for other works by this author on: This Site PubMed Google Scholar P Tsao; P Tsao 2 Stanford University School of Medicine, USA Search for other works by this author on: This Site PubMed Google Scholar M Kimoto; M Kimoto 3 Okayama Prefectural University, Japan Search for other works by this author on: This Site PubMed Google Scholar AJ Patterson; AJ Patterson 2 Stanford University School of Medicine, USA Search for other works by this author on: This Site PubMed Google Scholar P Vallance; P Vallance 1University College London, UK Search for other works by this author on: This Site PubMed Google Scholar JP Cooke JP Cooke 2 Stanford University School of Medicine, USA Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (2002) 103 (s47): 15P. https://doi.org/10.1042/cs103015Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation V Achan, M Stuehlinger, S Adimoolam, P Tsao, M Kimoto, AJ Patterson, P Vallance, JP Cooke; Metabolism of Endogenous Nos Inhibitors Lowers Blood Pressure and Regulates Nitric Oxide Synthesis following Hindlimb Ischaemia. Clin Sci (Lond) 1 July 2002; 103 (s47): 15P. doi: https://doi.org/10.1042/cs103015Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 2002 The Biochemical Society and the Medical Research Society2002 Article PDF first page preview Close Modal You do not currently have access to this content.
Approximated closed form characteristic impedance for the bed of nails-based gap waveguide (2010)

The parallel-plate ridge gap waveguide has been introduced recently. It consists of a metal ridge in a metamaterial magnetic conductor surface, covered by a metallic plate at a small height above it. The metamaterial surface is designed to provide a frequency band where parallel-plate modes are in cut-off, thereby allowing for a conned gap wave to propagate along the ridge. In this paper, the investigation upgrades the analytical expression of the modal dispersion equation given previously, by including the first higher order mode. Furthermore, the characteristic impedance of the dominant mode is analytically calculated, by means of three different closed form expressions.
Comparison of isopropanol and isooctane as food simulants in plasticizer migration tests (1998)

In the last 25 years, plastics have faced a massive demand in packaging technology due to their desirable properties, such as flexibility, light weight, etc. Moreover, their packaging applications have spread in the area of food and pharmaceutical products. Much concern has arisen from that fact as most of these plastics contain high amounts of additives which tend to migrate when they come into contact with liquid or solid surrounding media. Plasticized PVC is one of the most popular polymers in packaging technology and at the same time is subject to criticism for the high concentration levels of plasticizer in most of its applications. In an attempt to carry out simple and realistic migration tests, many investigators used simple organic substances which simulate as much as possible the behaviour of foods towards plasticizer migration. Much of our previous work intended to examine migration of dioctyl phthalate (DOP) from PVC sheets into some simple surrounding media, such as methanol, white spirit, paraffin oil, etc. The present work is focused on the examination of the plasticizer migration into two promising food simulants, namely isopropanol and isooctane. Radioactivity measurements were employed in order to detect quantitatively the plasticizer which had migrated into the surrounding liquid. In contrast to similar studies, the phenomenon of migration was studied until equilibrium was reached.
STEP-Elterntraining - Wege zu erfüllten familiären Beziehungen (2011)

Eltern sind heute mit großen Herausforderungen konfrontiert. Angesichts der Flut widersprüchlicher und verwirrender Informationen über Erziehung bietet das STEP-Elterntraining eine leicht erlernbare Methode. Sie hilft, Beziehungen zwischen Eltern und Kindern zu verbessern mit dem Ziel des gegenseitigen Respekts. Sie hilft Eltern, ihre Kinder zu verantwortungsbewussten Menschen zu erziehen. Forschungsergebnisse der Universität Bielefeld bestätigen, dass Eltern durch STEP das Vertrauen in ihre Fähigkeiten steigern und Überreaktionen und Dauerstress reduziert werden. Das Konzept und seine praktische Umsetzung stehen im Mittelpunkt des Buches.
Microsomal Styrene Mono-oxygenase and Styrene Epoxide Hydrase Activities in Rats (1976)

1. Styrene epoxide formation and styrene epoxide hydration have been studied in liver, lung, kidney, heart, spleen and brain of female and male rats.2. Styrene epoxide formation is NADPH-dependent although it is enhanced when NADH is added together with NADP. This enzymic activity is inhibited by metyrapone and SKF 525-A but not by the effective inhibitors of epoxide hydrase, l,2-epoxy-3,3,3-trichloropropene and cyclohexene oxide.3. Known inducers of liver microsomal mono-oxygenases show a different activity on the two enzymes. Phenobarbital increases both formation and hydration of styrene epoxide; and carbamazepine increase the hydration but not the formation of styrene epoxide; a steroid contraceptive combination (lynestrenol + mestranol) increases styrene epoxide formation while it inhibits epoxide hydrase; 3-methylcholanthrene does not affect either of the activities.
Effect of Sperm Preparation Techniques by Density Gradient on Intra-Individual Variation of Sperm Motility (2007)

The purpose of this study was to examine the effect of sperm preparation by density gradient on the intra-individual variation in sperm motility. Patients presenting for density gradient (DG) sperm preparation were analyzed retrospectively. Patients who had more than one preparation were included. The variation within each patient was studied using the coefficient of variation (CV = standard deviation/mean x 100). Density gradient preparation resulted in a reduction in the CV of sperm motility (CV motility before DG: 19.8 +/- 15.82% vs. CV motility after DG: 15.9 +/- 17.97%, p < 0.001). However, CV of sperm concentration (44.2 +/- 26.51%) and CV progressively motile sperm (49.2 +/- 28.48%) remained very high after DG. This variability should be reflected in counseling patients undergoing intrauterine insemination.
Influenza serological assays: from agar to plasmid-based approaches (2016)

Minireview on serological assays for influenza.