2233 THE EFFECT OF STATIN MEDICATIONS ON URINARY STONE FORMATION: A TEN YEAR REVIEW OF ARMED-FORCES HEALTH LONGITUDINAL TECHNOLOGY APPLICATION (AHLTA) DATABASE (2011)

You have accessJournal of UrologyStone Disease: Evaluation & Medical Management1 Apr 20112233 THE EFFECT OF STATIN MEDICATIONS ON URINARY STONE FORMATION: A TEN YEAR REVIEW OF ARMED-FORCES HEALTH LONGITUDINAL TECHNOLOGY APPLICATION (AHLTA) DATABASE James Masterson, Roger Sur, James L'Esperance, Brian Auge, and Marshall Stoller James MastersonJames Masterson San Diego, CA More articles by this author , Roger SurRoger Sur San Diego, CA More articles by this author , James L'EsperanceJames L'Esperance San Diego, CA More articles by this author , Brian AugeBrian Auge San Diego, CA More articles by this author , and Marshall StollerMarshall Stoller San Francisco, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2474AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The pathogenesis of urinary stone formation has not been elucidated. Traditional theories of abnormal urine chemistries do not fully explain urinary stone disease. Recently, vascular disease, hypertension, and obesity have been associated with stone formation. The purpose of this study was to investigate the relationship between hyperlipidemia and nephrolithiasis as well as the impact of statin medications on stone formation. METHODS The AHLTA patient medical records from the Southwestern United States region was queried (January 2000–October 2010) to identify adult patients with hyperlipidemia. AHLTA database is an electronic medical record for all active duty members, dependents and retirees. We then created two predictor variables – with and without anti-hyperlipidemic drugs–with the outcome variable as urinary stones. All subjects with a diagnosis of urolithiasis diagnosis were identified as well. Descriptive and univariate analysis was performed. RESULTS 57,320 patients (36,341 men) were identified with hyperlipidemia. 32,386 (20,064 men) patients were prescribed statin medications including 1,030 of them (724 men, 306 women) who developed a stone. Stones developed in 962 (617 men, 345 women) patients who were not taking a statin medication. 6,313 patients were identified as having urolithiasis, including 3897(62.7%) men. 1,992(31.7%) of patients with stones also had hyperlipidemia. The probability of a patient with hyperlipidemia having a diagnosis of urolithiasis while on a statin medication was OR=0.819 (95% CI=0.749–0.895, p<0.0001) [OR=0.962 men (95% CI=0.863–1.074, p=.529) 0.599 women(95%CI=0.512–0.700, p<.001)]). CONCLUSIONS We confirmed the relationship of urinary stone disease with hyperlipidemia. Moreoever, the use of statin medication, with the assumed reduction in hyperlipidemia, appears to reduce the risk of stone disease, more pronounced for females. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e896 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information James Masterson San Diego, CA More articles by this author Roger Sur San Diego, CA More articles by this author James L'Esperance San Diego, CA More articles by this author Brian Auge San Diego, CA More articles by this author Marshall Stoller San Francisco, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...