gebhart/patrepeval huggingface dataset:
Cyano Triphenyl Phosphonium Ylides Stabilized by Ester or Keto Groups: Computed Conformations and Crystal Structures (2007)

The mixed stabilized triphenyl phosphonium ylides Ph3P = C(CN)CO-R and Ph3P = C(CN)COOR, R = CH3, C2H5, CH(CH3)2, 1a,c and 2a,b, respectively, have sharp 1H and 13C NMR signals, except for 2b in some conditions. Ab initio geometrical optimizations indicate that in the preferred conformer the acyl oxygen is syn- to phosphorus, with barriers to rotation about the ylidic bond of 15–18 kcal. mol−1, and differences between the syn- and anti-conformers of ca. 4 and 11 kcal. mol−1 for the keto and ester derivatives, respectively. These energetic differences are not very sensitive to changes in the alkyl group, R, or the level of computation. The computed geometries indicate that the ylidic moieties are approximately planar with extensive electronic delocalization, as in crystalline 1a and 2a. The 13C NMR signals of the ylidic carbons are shifted strongly up field, consistent with their anionoid character.
Effect of Combination Therapy With Simvastatin and Carvedilol in Patients With Left Ventricular Dysfunction Complicated With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention (2006)

Combination therapy with simvastatin and carvedilol had a positive impact on the endpoints of cardiovascular death and MACE and seems to have an additive beneficial effect on these endpoints in patients with LV dysfunction complicated with AMI who underwent PCI.
Solid State NMR Investigations of Zeolite - Intercalate Structures (2006)

We will describe two topics in which structural information on complexes of zeolites is obtained from solid state NMR. In the first, recent work on the determination of the complete three-dimensional structures of the complexes of zeolites with organic sorbates will be briefly reported. The method has been optimized and the presentation of the results systematized. In the second topic, we will describe how solid state NMR can be used in the reverse sense to probe for the existence and structures of “nanocrystals” whose dimensions are too small to give proper Bragg scattering and which have been proposed to be the synthesis route for the formation of zeolite ZSM-5. In this study, the spectral parameters of “probe” template molecules are used as being diagnostic of whether the local environment of the framework has been formed. These are independent of the “crystal” dimensions and this general approach may be applicable to other similar “nano” systems.
Conformational and chemical consequences of vicinal polar bonds (1973)

A relationship exists between conformational energy differences in 1,2-disubstituted ethanes and the polar nature of the substituents; a parallel may be drawn with the observed stereochemistry of addition to olefins.
IgG4 levels in relation to Olea europaea immunotherapy. (1994)

We determined olive pollen-specific IgG4 levels in 100 patients, 39 of whom had been subjected to no immunotherapy (IT) for Olea (31 allergic and 8 nonallergic individuals) and 61 of whom had been administered IT as extracts, including Olea pollen (29 extracts in BUs, 24 allergenic extracts polymerized with glutaraldehyde:Allergoid and 8 extracts standardized in PNUs). IgG4 levels were correlated to the clinical picture, type of extract and average cumulative dose (ACD). We found average IgG4 levels of 0.80 +/- 0.74, 8.60 +/- 13.07 (p < 0.01) and 1.42 +/- 2.5 micrograms/ml (n.s.) for the untreated group and those treated with BU and Allergoid, respectively. The difference between the IT-BU-treated and IT-Allergoid-treated patients was significant at p < 0.01. On the other hand, we found no significant differences among the average IgG4 levels of the three groups in relation to age or sex. The group of asthmatic patients treated with BU extracts had average IgG4 levels of 16 +/- 17.34 micrograms/ml, while those of the rhinoconjunctivitic, non-asthmatic group were 5.05 +/- 6.149 micrograms/ml, with p < 0.05 (Student's "t" test). Thus, patients treated with extracts polymerized with glutaraldehyde had IgG4 levels that were similar to those of the patients subjected to no IT. Also, the group treated with IT extracts standardized in BUs had increased IgG4 levels that were correlated with the cumulative dose, particularly in asthmatic patients.
Synthesis and Evaluation of Immobilized Androgens for Affinity Chromatography in the Purification of Nuclear Androgen Receptor (1984)

No AccessJournal of Urology1 Oct 1984Synthesis and Evaluation of Immobilized Androgens for Affinity Chromatography in the Purification of Nuclear Androgen Receptor M.-A. De Larminat, N. Bruchovsky, P.S. Rennie, S.P. Lee, and G. Tertzakian M.-A. De LarminatM.-A. De Larminat More articles by this author , N. BruchovskyN. Bruchovsky More articles by this author , P.S. RennieP.S. Rennie More articles by this author , S.P. LeeS.P. Lee More articles by this author , and G. TertzakianG. Tertzakian More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)49922-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Synthesis and Evaluation of Immobilized Androgens for Affinity Chromatography in the Purification of Nuclear Androgen Receptor." The Journal of Urology, 132(4), p. 851 © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 132Issue 4October 1984Page: 851 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information M.-A. De Larminat More articles by this author N. Bruchovsky More articles by this author P.S. Rennie More articles by this author S.P. Lee More articles by this author G. Tertzakian More articles by this author Expand All Advertisement Loading ...
Über die gemeinsame Einwirkung von elementarem Schwefel und gasförmigem Ammoniak auf Ketone, XXXVIII. Einwirkung von Schwefel und Ammoniak auf Acetophenon, III. Strukturbeweis und Reaktionen der Imidazolin‐Δ<sup>3</sup>‐thione‐(5) (1964)

Abstract Das aus Schwefel, Ammoniak und Acetophenon entstehende 2‐Methyl‐2.4‐diphenyl‐imidazolin‐Δ 3 ‐thion‐(5) (I) wird auch aus Benzoylcyanid, Acetophenon, Ammoniak und Schwefelwasserstoff erhalten. Diese allgemein anwendbare Synthese stellt einen neuen Beweis für die Konstitution der Imidazolin‐Δ 3 ‐thione‐(5) dar und erlaubt die Darstellung von Derivaten, die durch Einwirkung von Schwefel und Ammoniak auf Acetophenon oder dessen Kern‐substituierte Derivate nicht zugänglich sind; aliphatische Acycyanide sind ebenfalls verwendbar. Substitutionsmöglichkeiten am Ringsystem von I bzw. XVIII werden untersucht. Imidazolin‐Δ 3 ‐thione‐(5) gehen durch Oxydation in Imidazolin‐Δ 3 ‐one‐(5) über. Das aus I bei der Oxydation entstehende 2‐Methyl‐2.4‐diphenyl‐imidazolin‐Δ 3 ‐on‐(5) (XVIII) wird auch durch Umsetzung von Phenylglyoxylsäureamid mit Acetophenon und Ammoniak hergestellt. ‐ Es wird gezeigt, daß aliphatische Methylketone mit Schwefel und Ammoniak ebenfalls Imidazolin‐Δ 3 ‐thione‐(5) ergeben.
Binding, uptake, and degradation of internalized thyroglobulin in cultured thyroid and non-thyroid cells. (2012)

Thyroid hormone release requires degradation of thyroglobulin (Tg) by thyroid epithelial cells, which occurs mainly in the lysosomal pathway following Tg endocytosis. Non-specific fluid-phase endocytosis is thought to be the main route of Tg uptake leading to degradation, whereas receptor- mediated endocytosis is believed to lead to post-endocytic pathways other than degradation. To gain more insights into these issues, we investigated handling of Tg by various cell types. Tg bound similarly to thyroid (FRTL-5, FRT) and non-thyroid (COS-7, IRPT) cells, indicating the presence of membrane-binding sites, presumably receptors, in both cell types. Tg was internalized and degraded by all cells and degradation paralleled uptake, with the exception of FRTL- 5 cells, in which a lower proportion of Tg was degraded, suggesting that in FRTL-5 cells mechanisms that target Tg to the various post-endocytic pathways (either receptors or postreceptorial factors) are differently represented. Immunoelectronmicroscopy showed a common path of endocytosis in FRTL-5, COS-7, and IRPT cells, namely the formation of pseudopods engulfing Tg, followed by internalization and accumulation of Tg in cytoplasmic vesicles and lysosomes. The fastest rate was observed in COS-7 cells, probably reflecting a lower impact of endocytic receptors. Our findings suggest that Tg uptake and degradation are not thyroid-specific, that Tg binding sites exist in different cell types, and that uptake and/or degradation are differently regulated in differentiated thyroid cells, presumably because of a different impact of endocytic receptors or post-endocytic mechanisms, which are probably responsible for the regulation of hormone release.
Complete unbinding and quasi-long-range order in lamellar phases (1987)

Lamellar phases of lyotropic liquid crystals can be swollen by addition of solvent. Such a process, which leads to a strong increase of the mean interlamellar separation l\ifmmode\bar\else\textasciimacron\fi{}, can be viewed as a phase transition, termed complete unbinding. Starting from the microscopic interaction for a pair of lamellae, we derive an effective model for the multilayer phase. We predict a power-law increase of l\ifmmode\bar\else\textasciimacron\fi{}, and show that the system exhibits quasi-long-range translational order characterized by an exponent ${X}_{m}$, which is either universal or, for sufficiently long-range repulsive interactions, depends on molecular details.
Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation (2002)

The aim of the present study was to investigate the effects of the novel poly(ADP-ribose) polymerase (PARP) inhibitor PJ34 (N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide) on myocardial and endothelial function after hypothermic ischemia and reperfusion in a heterotopic rat heart transplantation model. After a 1-hour ischemic preservation, reperfusion was started either after application of placebo or PJ34 (3 mg/kg). The assessment of left ventricular pressure-volume relations, total coronary blood flow, endothelial function, myocardial high energy phosphates, and histological analysis were performed at 1 and 24 hours of reperfusion. After 1 hour, myocardial contractility and relaxation, coronary blood flow, and endothelial function were significantly improved and myocardial high energy phosphate content was preserved in the PJ34-treated animals. Improved transplant function was also seen with treatment with another, structurally different PARP inhibitor, 5-aminoisoquinoline. The PARP inhibitors did not affect baseline cardiac function. Immunohistological staining confirmed that PJ34 prevented the activation of PARP in the transplanted hearts. The activation of P-selectin and ICAM-1 was significantly elevated in the vehicle-treated heart transplantation group. Thus, pharmacological PARP inhibition reduces reperfusion injury after heart transplantation due to prevention of energy depletion and downregulation of adhesion molecules and exerts a beneficial effect against reperfusion-induced graft coronary endothelial dysfunction.
Observability and policy optimization for mobile robots (2004)

This paper considers the use of abstract descriptions of motion control programs and of the environment, and explores some new problems of system theoretic interest that arise as a result. Wc study the problem of active localization for a mobile robot moving on a sparsely-described uncertain environment and show how that problem can be posed as that of observability of a finite automaton. We present algorithms (based on Hidden Markov Models) that answer the question of i) whether or not a representation of the environment (in the form of a directed graph) is observable, and ii) what is the shortest navigation policy that allows the robot to uniquely identify its location on the graph.
Optical Absorption of Cuprous Oxide (1961)

The relative optical absorption coefficient $\ensuremath{\alpha}$ of polycrystalline slabs of cuprous oxide was measured at 295\ifmmode^\circ\else\textdegree\fi{}K, 77\ifmmode^\circ\else\textdegree\fi{}K, and 4.2\ifmmode^\circ\else\textdegree\fi{}K. At 4.2\ifmmode^\circ\else\textdegree\fi{}K, $\ensuremath{\alpha}$ is proportional to ${[\ensuremath{\sigma}\ensuremath{-}{E}_{0}]}^{\frac{1}{2}}$ for $16510 {\mathrm{cm}}^{\ensuremath{-}1}<~\ensuremath{\sigma}<~16900 {\mathrm{cm}}^{\ensuremath{-}1}$, where $\ensuremath{\sigma}$ is the wave number. At 77\ifmmode^\circ\else\textdegree\fi{}K an additional component appears, so that $\ensuremath{\alpha}={\ensuremath{\alpha}}_{1}+{\ensuremath{\alpha}}_{2}$, with ${\ensuremath{\alpha}}_{1}\ensuremath{\propto}{[\ensuremath{\sigma}\ensuremath{-}{E}_{1}]}^{\frac{1}{2}}$ and ${\ensuremath{\alpha}}_{2}\ensuremath{\propto}{[\ensuremath{\sigma}\ensuremath{-}{E}_{2}]}^{\frac{1}{2}}$. This is attributed to indirect transitions to exciton levels, in agreement with a theory by Elliott. The ratio of the integrated absorption coefficient of the first two exciton lines, after corrections for the background were applied, is also in satisfactory agreement with the Elliott theory.
A Catalytic Asymmetric Vinylogous Mukaiyama Aldol Reaction (2007)

A vinylogous Mukaiyama aldol reaction, conducted using 10 mol % of a BITIP catalyst and B(OMe)3 as an additive, effects an enantioselective four-carbon chain extension to give versatile E-alpha,beta-unsaturated thiol esters.
Advanced Characterization of Electrocatalyst Interfaces (2016)

In PEM fuel cells, electrocatalyst interfaces including Pt-C, Pt-ionomer, C-ionomer interfaces, play a critical role for both performance and durability. 1-3 Pt-C interface influences the stability and activity of Pt dramatically; electrocatalyst/ionomer interfaces 4 in fuel cell catalyst layers determine the electrochemical surface area (ECSA), local transport, and structural stability of catalyst layer. Delineating the structure evolution of the interfaces in response to PEM fuel cell operating environment will provide the science foundation for new electrocatalyst/catalyst layer design therefore improve the performance and durability of PEM fuel cells. We have developed an aberration corrected environmental transmission electron microscopy (ETEM), which allows unprecedented spatial and temporal resolution in the relevant gas environment, such as O 2 , H 2 , H 2 O, CO, CH 4 , and CO 2 . With customized intelligent gas delivery system, the gas environment relevant to PEM fuel cell anode and cathode (H 2 /H 2 O, O 2 /H 2 O) can be simulated and precisely controlled through the residual gas analyzer (RGA). The ETEM opens new avenue to study the dynamic changes of electrocatalyst interfaces. In order to study the surface chemistry of catalysts under different environment, a specially-designed pre-treatment system is integrated into X-ray photoelectron spectroscopy (XPS), which allows us to move catalysts seamlessly between the pre-treatment system and XPS chamber so that surface contamination from external environment will be eliminated. In this talk, we will present our recent progress on identifying both structure and surface chemistry evolution and their correlation in electrocatalysts under PEM fuel cell relevant environment through the combination of ETEM and XPS capabilities. 1. Y. Y. Shao, G. P. Yin and Y. Z. Gao, J. Power Sources , 2007, 171 , 558-566. 2. S. Park, Y. Y. Shao, H. Y. Wan, V. V. Viswanathan, S. A. Towne, P. C. Rieke, J. Liu and Y. Wang, J. Phys. Chem. C , 2011, 115 , 22633-22639. 3. R. Kou, Y. Y. Shao, D. H. Mei, Z. M. Nie, D. H. Wang, C. M. Wang, V. V. Viswanathan, S. Park, I. A. Aksay, Y. H. Lin, Y. Wang and J. Liu, J. Am. Chem. Soc. , 2011, 133 , 2541-2547. 4. A. Z. Weber and A. Kusoglu, J. Mater. Chem. A , 2014, 2 , 17207-17211.
Corrosion and stability study of<i>Bacillus thuringiensis var. kurstaki</i>starch industry wastewater-derived biopesticide formulation (2014)

Biopesticides are usually sprayed on forests by using planes made up of aluminum alloy. Bioval derived from starch industry wastewater (SIW) in suspension form was developed as stable anticorrosive biopesticide formulation. In this context, various anticorrosion agents such as activated charcoal, glycerin, ethylene glycol, phytic acid, castor oil and potassium silicate were tested as anticorrosive agents. There was no corrosion found in Bioval formulation where potassium silicate (0.5% w/v) was added and compared with Foray 76 B, as an industrial standard, when stored over 6 months. In relation to other parameters, the anticorrosion formulation of Bioval+buffer+KSi reported excellent zeta potential (-33.19 ± 4 mV) and the viscosity (319.13 ± 32 mPa.s) proving it's stability over 6 months, compared to the standard biopesticide Foray 76 B (-36.62 ± 4 mV potential zeta, pH 4.14 ± 0.1 and 206 ± 21 mPa.s viscosity). Metal analysis of the different biopesticides showed that Bioval+buffer+KSi has no corrosion (5.11 ± 0.5 mg kg(-1) of Al and 13.53 ± 1.5 mg kg(-1) of Fe) on the aluminum alloy due to the contribution of sodium acetate buffer at pH 5. The bioassays reported excellent results for Bioval+Buffer+KSi (2.95 ± 0.3 × 10(9) CFU mL(-1) spores and 26.6 ± 2.7 × 10(9) IU L(-1) Tx) compared with initial Bioval (2.46 ± 0.3 × 10(9) CFU mL(-1) spores and 23.09 ± 3 × 10(9) IU L(-1) Tx) and Foray 76 B (2.3 ± 0.2 × 10(9) CFU mL(-1) spores and 19.950 ± 2.1 UI L(-1) Tx) which was due to the break-up of the external chitinous membrane due to abrasive action of potassium silicate after ingestion by insects. The contribution of sodium acetate buffer and potassium silicate (0.5% and at pH = 5) as anticorrosion agent in the Bioval allowed production of an efficient biopesticide with a reduced viscosity and favorable pH as compared to Foray 76 B which enhanced the entomotoxic potential against spruce budworm (SB) larvae (Lepidoptera: Choristoneura fumiferana).
Serum hepcidin concentration in chronic haemodialysis patients: associations and effects of dialysis, iron and erythropoietin therapy (2009)

Hepcidin levels in stable haemodialysis patients appear to reflect systemic iron load, but not inflammation. Due to the negative association between reticulocyte counts and hepcidin, the reduction of circulating hepcidin concentrations by dialysis and/or rhEpo treatment may positively affect erythropoiesis.
ELIMINATION OF MYCOPLASMA FROM THE TURKEY SEMEN (2002)

The studies were carried out in a breeding turkey flock in which mycoplasma infections were detected (serologically and by isolation from semen). Trials using tylosin and enrofloxacin were carried out to limit the infection. The antibiotics were given to the birds for 5 days in therapeutic doses and to semen at concentration of 1 mg/ ml of semen. The effectiveness of such treatments was confirmed by negative results of mycoplasma isolation from semen of turkey males and from the cloaca of turkey hens. As a result, an improvement in reproductive performances was observed. Hatchability was higher by 15% and 27% after the addition of enrofloxacin and tylosin, respectively.The progeny were free of mycoplasmas. The effectiveness of the method used was confirmed during two consecutive months.
Charge-State Dependence of Electron Loss from H by Collisions with Heavy, Highly Stripped Ions (1978)

Theoretical calculations, confirmed by experimental measurements, are used to obtain a new scaling rule for electron loss from a hydrogen atom in collision with a heavy, highly stripped ion. The calculations cover the energy range 50 to 5000 keV/amu and charge states $q$ from 1 to 50. The experiments are in the range 108 to 1140 keV/amu and charge states 3 to 22. A simple analytic expression that describes the electron-loss cross section for $1<~q<~50$ in the energy range 50 to 5000 keV/amu is presented.
Characterization and modeling of memory effects in RF power transistors (2011)

This chapter discusses memory effects exhibited by transistors and how they affect their large-signal RF performance. Memory effects include self-heating, traps, and parasitic bipolar effects in SOI-MOSFETs. Distributed and transient thermal models will be discussed first. Large-signal measurement techniques for characterizing memory effects in transistors using pulsed biased and pulsed-RF large-signal measurements will be presented. Results from combined deep-level optical spectroscopy and large-signal measurement will then be introduced. Finally, the correlation between trapping and noise will be discussed. The chapter will conclude then with a discussion of the cyclostationary effect, according to which the average trapping population and device noise characteristics can be altered by the fast RF signals under large-signal RF operation.
The use of mitomycin in pterygium surgery. (1993)

We report on the use of mitomycin drops after the surgical removal of pterygiums in 70 patients. Our results justify the use of mitomycin as a standard postoperative procedure in preference to other treatments.
A PROPOSAL OF PRACTICAL METHOD OF STABILITY DESIGN FOR STEEL FRAMES (1993)

終局限界状態のうち座屈設計が問題となるような鋼ラーメン構造物を対象にした実務レベルの新しい設計法を提案している. 従来の設計法における有効座屈長を用いた耐荷力評価法に疑問の余地があることから, ここでは, 有効座屈長の概念にとらわれないで安全性照査を容易にできるように,ζ関数を導入するなどの工夫をしている. 具体的に,実橋レベルの多層ラーメン構造物に適用して, その有効性を明らかにした.
Nickel(0)‐Mediated [3 + 2 + 2] and [2 + 2 + 2 + 1] Cyclization Reactions of Chromium Fischer Carbene Complexes and Alkynes. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Improving Faculty Feedback to Resident Trainees during a Simulated Case (2013)

Quality of faculty feedback to a simulated resident was improved in the interventional group in a number of areas after a 1-h educational intervention, and this short intervention allowed a group of faculty to overcome enough discomfort in addressing a professionalism lapse to discuss it directly.
Microbial Biosynthesis and Applications of Gentamicin: A Critical Appraisal (2008)

Gentamicin is an aminoglycoside antibiotic produced by various species of the genus Micromonospora and has received much attention in the recent years as a broad-spectrum antibiotic for treatment of various infections. It exists as a complex of closely related aminoglycoside structures and the clinically significant one is the gentamicin C complex. This review article focuses attention on the present status of knowledge and the main advancements achieved in the last few decades on the subject of gentamicin with regard to its production, biosynthetic pathway, mode of action, and uses. The various nutritional and environmental parameters affecting gentamicin production and the factors affecting the release of bound gentamicin are discussed. Further, strain improvement using UV and/or chemical mutagenesis can be applied to augment the efficiency of the producer strain and a number of case studies are presented. Different detection and quantitative methods for gentamicin estimation and the mode of action of gentamicin are discussed in detail. This antibiotic finds extensive use in combination chemotherapy and as a drug for different delivery agents for treatment of osteomyelitis and other recent applications in gene therapy.
Development of Tubulin-Polymerization Inhibitors Based on the Thalidomide Skeleton (2007)

We synthesized a series of compounds based on the potent tubulin-polymerization inhibitor 5-hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [5HPP-33 (3)], which is structurally derived from thalidomide (1), and investigated their inhibitory effects on tubulin polymerization. Direct interaction between 5HPP-33 (3) and alpha,beta-tubulin heterodimer protein was demonstrated by means of a surface plasmon resonance study.