gebhart/patrepeval huggingface dataset:
Acoustic Propagation Uncertainty in the Shallow East China Sea (2006)

Acoustic transmission loss (TL) and supporting ocean environmental data collected during the Asian Seas International Acoustics Experiment (ASIAEX) on June 3, 2001, in the East China Sea (ECS), in a water depth of approximately 100 m are presented. Objectives of the data analysis are to explore the stochastic nature of TL in terms of the mean (mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TL</sub> ) and the fluctuations around the mean (as described by the standard deviation (sigma <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TL</sub> ) and higher order statistics). In particular, we conjecture that mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TL</sub> robustly reflects the macrostate of the ocean, including the bottom, whereas uncertainties in TL as measured by sigma <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TL</sub> are related to the microstate of the ocean, again including the bottom. Comparisons are made to TL data at a similar location, 200 km from the ASIAEX site, in waters of the same depth, by the Harsh Environment Program in September 1997. The TL is shown to be approximately horizontally isotropic with exception to a discrete anisotropic feature likely caused by internal waves. Various mechanisms of uncertainty are discussed to describe the microstate. These were not sufficiently resolved to identify the primary cause of variability
[Fever from the cold--familial cold autoinflammatory syndrome]. (2009)

Familial cold autoinflammatory syndrome (FCAS) is a dominantly inherited syndrome caused by mutations of the CIAS1 gene. It is characterized by recurrent episodes involving fever, urticaria, articular symptoms and conjunctivitis. The episodes may be associated with exposure to cold. In some families, association with reactive AA amyloidosis has been described for the syndrome. We describe a Finnish family, in which at least 16 persons were affected with FCAS, and one person had been diagnosed with renal amyloidosis.
Additions and Corrections: The Ismerism of Dithiolphalates. (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections: The Ismerism of Dithiolphalates.John Sheehan and Gerald F HollandCite this: J. Am. Chem. Soc. 1957, 79, 24, 6577Publication Date (Print):December 1, 1957Publication History Published online19 May 2004Published inissue 1 December 1957https://pubs.acs.org/doi/10.1021/ja01581a622https://doi.org/10.1021/ja01581a622research-articleACS PublicationsRequest reuse permissionsArticle Views13Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Epitope Analysis and Primary Structures of Variable Regions of Anti-human FcεRI Monoclonal Antibodies, and Expression of the Chimeric Antibodies Fused with Human Constant Regions (2000)

The structural analysis of monoclonal antibodies (mAbs) against the alpha subunit of the high affinity IgE receptor (FcepsilonRIalpha) is an alternative approach to obtaining information for the design of inhibitors that will block complementary interaction between IgE and FcepsilonRIalpha and to analyzing the various biological effects induced by anti-FcepsilonRIalpha autoantibodies in chronic urticaria. In this study, epitopes for mouse anti-human FcepsilonRIalpha mAbs and primary structures of variable regions of the mAbs were analyzed. Three mAbs inhibitory for IgE-binding reacted to the deletion mutants of FcepsilonRIalpha containing the whole second immunoglobulin-like domain as well as IgE did. On the other hand, two uninhibitory mAbs reacted to those containing the whole first immunoglobulin-like domain. The cDNAs for variable regions of the five mAbs were cloned and sequenced. Two inhibitory mouse/human chimeric antibodies were expressed in COS7 cells and bound to Chinese hamster ovary transfectant cells expressing FcepsilonRI (CHO/alphabetagamma), and these inhibited the binding of IgE to CHO/alphabetagamma cells.
The UK Government policy on farm animal genetic resource conservation (2004)

Abstract Historically the UK has not had or needed a defined Government policy on the conservation and utilisation of farm animal genetic resources. However, this situation has changed recently, partly as a result of international efforts, stimulated by the Convention on Biological Diversity, and led by the Food and Agricultural Organisation of the United Nations, to co-ordinate national strategies for conservation and utilisation of farm animal genetic resources. As part of this international effort, a National Consultative Committee was set up in the UK in 2001. This committee produced the UK Country Report on farm animal genetic resources, which was published in 2002 and submitted to FAO. This paper outlines the structure and recommendations of this report, and discusses government policy on farm animal genetic resources.
Association of RFLP of HLA class I genes with Chinese ankylosing spondylitis patients (1989)

By serum typing, it is indicated that HLA B27 may be associated with the susceptibility to ankylosing spondylitis (AS). We analyzed DNA restriction fragment length polymorphism (RFLP) in 28 Chinese AS patients and 99 healthy controls, using a 1.4 Kb HLA class I cDNA probe. The results showed that the frequencies of the 8.1 Kb EcoRI, 5.2 Kb EcoRI and 21.9 Kb XbaI fragments were found to be significantly increased in affected patients (P less than 0.0001, P = 0.0015, respectively), but that of 19.2 Kb XbaI fragment was decreased (P = 0.0021). The data suggest that AS may be a polygenic disease; furthermore, B27 and 8.1 Kb EcoRI band may be two different factors responsible for the susceptibility or just in linkage disequilibrium with the susceptible gene(s).
Dose-dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function (1990)

Caffeine clearance was determined in 13 healthy control subjects and in 13 patients with histologically proven cirrhosis. On separate occasions, 70 mg, 200 mg, and 300 mg single doses of anhydrous caffeine were administered orally with decaffeinated coffee to each subject. Subjects were analyzed individually, acting as their own controls, thus reducing interindividual variability. The present study showed that caffeine exhibited dose-dependent pharmacokinetics, particularly in subjects who showed high initial clearance with the low dose (70 mg) of caffeine. There was a significant decrease in caffeine clearance with increasing dose from 70 mg to 300 mg (n = 26, p less than 0.01, Dunnett's test), indicating saturable caffeine metabolism in the dose range tested. These findings imply that if caffeine is to be used as a guide to deteriorating liver function, serial caffeine clearance estimations should be performed in each individual subject, with use of the same dose of caffeine each time.
Weakly interacting particle systems on inhomogeneous random graphs (2016)

We consider weakly interacting diffusions on time varying random graphs. The system consists of a large number of nodes in which the state of each node is governed by a diffusion process that is influenced by the neighboring nodes. The collection of neighbors of a given node changes dynamically over time and is determined through a time evolving random graph process. A law of large numbers and a propagation of chaos result is established for a multi-type population setting where at each instant the interaction between nodes is given by an inhomogeneous random graph which may change over time. This result covers the setting in which the edge probabilities between any two nodes is allowed to decay to $0$ as the size of the system grows. A central limit theorem is established for the single-type population case under stronger conditions on the edge probability function.
Thermal characterization of liquids and polymer thin films using a microcalorimeter (2005)

This paper presents an integrated microfluidic thermal sensor that can be used to characterize the thermal properties of nanoliter quantities of fluids and polymer thin films. The device consists of a polycrystalline silicon (polysilicon) heater located in close proximity to the hot junctions of p+-polysilicon/gold microthermopiles fabricated on a thermally isolated membrane. ac calorimetric measurements were performed by introducing a periodic heat signal using the heater and detecting the frequency-dependent thermal signal response in the presence of various fluids and polymers. The thermal conductivity of different fluids and five typical polymers used in microfabrication was measured using this device.
Band Structure Effects on the Scaling Properties of [111] InAs Nanowire MOSFETs (2009)

We have investigated the scaling properties of [111] InAs nanowire MOSFETs in the ballistic limit. The nanowire band structure has been calculated with an sp <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> d <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> s* tight-binding model for nanowire diameters between 2 and 25 nm. Both the effective band gap and the effective masses increase with confinement. Using the atomistic dispersion relations, the ballistic currents and corresponding capacitances have been calculated with a semianalytical model. It is shown that the InAs nanowire MOSFET with diameters scaled below 15-20 nm can be expected to operate close to the quantum capacitance limit, assuming a high-kappa dielectric thickness of 1-1.5 nm. We have also investigated the evolution of f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> and the gate delay, both showing improvements as the device is scaled. The very small intrinsic gate capacitance in the quantum limit makes the device susceptible to parasitic capacitances.
Near IR Nonlinear Absorbing Chromophores with Optical Limiting Properties at Telecommunication Wavelengths (2007)

Dipolar and symmetrical heptamethine dyes featuring strong linear absorption in the near-infrared spectral range (700−900 nm) were prepared at a gram scale. X-ray crystallographic structure of the dipolar chromophore is described revealing the remarkable planarity of the polyenic chain due to the central ring of the molecule. These chromophores present promising nonlinear absorption properties at telecommunication wavelengths (1400−1600 nm): (i) significant two-photon cross-sections were measured using the femtosecond Z-scan method, and (ii) their exceptional solubility allows us to carry out an optical-limiting experiment at 1500 nm in the nanosecond regime. In this regime, experimental data were interpreted on the basis of two-photon absorption (2PA) and 2PA-induced excited-state absorption (ESA). Finally, these systems, which present a lot of relevant properties (significant nonlinear absorption properties, two-step gram scale synthesis, high solubility, good thermal stability, and several sites of functionalization), open the way to numerous practical applications in biology, solid-state optical limiting, and signal processing.
Laser electrodispersion as a new chlorine-free method for the production of highly effective metal-containing supported catalysts (2012)

Laser electrodispersion (LED) of metals is a promising technique for the preparation of heterogeneous catalysts as an alternative to wet impregnation of supports with the corresponding salt solutions. The LED technique can be used to deposit highly active chloride- and nitrate-free metal nanoparticles onto carbon or oxide supports. We report preparation and properties of new Ni-, Pd-, and Au-containing alumina-supported catalysts with low metal loadings (10 –3 –10 –4 % mass) and their comparison with the previously studied carbon (Sibunit) supported systems. The catalysts demonstrate high stability and extremely high specific catalytic activity (by 2–3 orders of magnitude higher than for traditional catalysts) in the gas-phase hydrodechlorination (HDC) of chlorobenzene (CB).
Electrochemically Obtained Insulating and Conducting Polymers and Composites of Acrylonitrile (1998)

ABSTRACT Electrochemically obtained polyacrylonitrile and a commercial polyacrylonitrile were heat treated to improve their conductivities. The parameters chosen for heat treatment conditions were the temperature, treatment medium (vacuum or air) and, doping agent. The conductivity of all heat treated polymers was measured. The characterization of the heat treated polymers was made by IR analysis. The composite films of polyacrylonitrile with polypyyrole and polythiophene were electrochemically prepared at different compositions. The change in the conductivity of composites was analyzed as a function of the percent composition of the insulating component. IR, DSC, TGA and SEM analyses were used to characterize the polymer composites.
Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes (2010)

Notch is a transmembrane receptor that mediates short-range signaling between neighboring cells. Notch signaling has been implicated in various cellular and developmental processes essential in the life of metazoans. Specifically, Notch signaling plays a critical role in mammalian skin. Removal of Notch alleles in skin keratinocytes has been associated with an array of phenotypes with varying severity based on the identity and number of remaining Notch receptors. Phenotypes include carcinogenesis: in the case of Notch1 loss), transformation of hair follicles to epidermal cysts and neonatal lethality, the latter seen in the absence of all Notch signaling. Although these phenotypes were previously described, the exact mechanisms underlying them have not been fully understood. This dissertation focuses on obtaining mechanistic insights into some of the observed phenotypes attained by analyses of the local and systemic changes downstream of Notch signaling loss in the skin. In order to examine the direct consequences of Notch loss in keratinocytes, we first focused on intrinsic changes detected at postnatal day 9 in Notch-deficient epidermis in vivo. Our findings helped establish that an additive function of Notch paralogs is required for proper epidermal differentiation and lipid biosynthesis in the epidermis, which in turn lead to formation of a competent skin-barrier. We showed that these functions were executed through both canonical: RBP-j-dependent) and non-canonical Notch signals. Accordingly, we discovered that the defective skin-barrier formed by Notch1-deficient keratinocytes created a sub-acute wound-like microenvironment that explained the tumor promotion seen in the absence of Notch1 in the skin. Therefore, skin carcinogenesis is a non-cell autonomous consequence of Notch deletion in keratinocytes, which represents the end result of a crosstalk between barrier-defective epidermis and its underlying stroma. Besides the intricate interaction between epidermis and its neighboring structures in the skin, we uncovered that defects in epidermal barrier sets off a systemic alarm by secreting thymic stromal lymphopoietin: TSLP), an epithelial-derived cytokine implicated in pathogenesis of asthma and atopic dermatitis. TSLP was highly expressed by Notch-deficient epidermis. Importantly, we were able to show that TSLP was both required and sufficient to cause a lethal systemic B-lymphoproliferative disorder in newborn or asthma in adult mice lacking Notch signaling in the skin. Overall, this body of work outlines the direct cellular effects of Notch loss, and describes the mechanisms connecting epidermal Notch deletion to its non-cell autonomous local and systemic consequences.
Adaptive routing algorithms and buffer management in multihop metropolitan area networks (2002)

Abstract The present study is devoted to multihop Metropolitan Area Network architectures characterized by some buffer capacity at the nodes and routing algorithm slightly more complex than those already present in the literature. A new adaptive routing algorithm and a new buffer management scheme are presented, and their performance are compared to that of the best algorithms known in the literature. Both the new proposals exhibit significant improvements in throughput and delay with respect to the older ones, for various MAN topologies, sizes and buffer dimensions. These results, which in some cases are very close to the theoretical optimum, are achieved with an implementation complexity well within the limits of present day technology.
Effect of Temperature and Wetness on Infection of Pear by<i>Venturia pirina</i>and the Relationship Between Preharvest Inoculation and Storage Scab (1991)

The effects of conidial inoculum dose and selected combinations of temperature and wetness duration on the incidence and severity of pear scab on fruit and foliage were studied. The relationship between the time of preharvest infection of pear fruit and the length of storage at -1 C before symptoms developed also was determined. Incidence and severity of scab on leaves and shoots of Bartlett pear seedlings increased linearly as inoculum concentration increased from 5×10 2 to 5×10 4 conidia per milliliter
Non-invasive surface-stripping for epifluorescence small animal imaging (2010)

Non-invasive near-infrared fluorescence (NIRF) imaging is a powerful tool to study pathophysiology in a wide variety of animal disease models including brain diseases. However, especially in NIRF imaging of the brain or other deeper laying target sites, background fluorescence emitted from the scalp or superficial blood vessels can impede the detection of fluorescence in deeper tissue. Here, we introduce an effective method to reduce the impact of fluorescence from superficial layers. The approach uses excitation light at two different wavelengths generating two images with different depth sensitivities followed by an adapted subtraction algorithm. This technique leads to significant enhancement of the contrast and the detectability of fluorochromes located in deep tissue layers in tissue simulating phantoms and murine models with stroke.
Induction of apoptosis by phloretin in HT‐29 human colon cancer cells (2006)

Phloretin is a flavonoid found in apples and apple‐derived products where it is present as the glucosidicform. Phloretin has been recognized as a promising cancer chemopreventive agent. The present study examined the effects of phloretin on apoptosis in HT‐29 human colon cancer cells. Cells were cultured with various concentrations of (0 ‐ 100 μmol/L) phloretin. Phloretin substantially inhibited the viable HT‐29 cell number and DNA synthesis in dose‐dependent manners. Annexin V staining of phosphatidylserine followed by flow cytometry revealed that phloretin induced apoptosis of HT‐29 cells in a dose‐dependent manner. Western blot analysis of total cell lysates revealed that phloretin induced cleavage of caspase‐8, ‐9, ‐7, and ‐3, and poly (ADP‐ribose) polymerase. We have demonstrated that phloretin inhibits cell proliferation and induces apoptosis in HT‐29 cells, which may be mediated by its ability to activate the caspase pathways. Our finding may lead to the development of new therapeutic strategies for the treatment of colon cancer.
Abstract 24031: Machine Learning Detection of Obstructive Hypertrophic Cardiomyopathy Using a Wearable Biosensor (2017)

Introduction: Hypertrophic cardiomyopathy (HCM) is a heart muscle disease characterized by left ventricular (LV) hypertrophy without a systemic etiology and is associated with heart failure, stroke and sudden death. Disease prevalence is estimated at 1:500, but ~84% remain undiagnosed. Patients with obstructive HCM (oHCM) have dynamic obstruction of the LV outflow tract and characteristic abnormalities in arterial bloodflow patterns. Hypothesis: Arterial pulsewaves recorded with a wearable biosensor and analyzed with machine learning algorithms could identify a signature of oHCM when compared to unaffected controls. Methods: We compared baseline arterial pulse wave morphology, obtained by photoplethysmography using an investigational wristworn biosensor (Wavelet Health, Mtn. View, CA), from oHCM patients enrolled in a digital health substudy of PIONEER HCM (NCT02842242) to unaffected controls from a Wavelet Health database. Five minute recordings were obtained at rest, and data sets were divided into training and validation cohorts. A beat-by-beat machine learning model was developed using a predefined feature set to calculate an HCM probability score, and an optimal threshold score was determined. The model was evaluated using summary statistics and an ROC area-under-curve metric. Results: Arterial pulsewave recordings were obtained from 14 patients with oHCM at rest and 81 unaffected controls. An oHCM machine learning classifier was developed based on 42 calculated metrics. After training and cross-validation (n=9 oHCM, n=48 control), the model achieved 98% accuracy. Application of this model to a validation cohort (n=5 oHCM, n=33 control) confirmed an increased probability in oHCM patients compared to unaffected controls (0.40 ± 0.13 vs. 0.18 ± 0.10; p=0.006). Analysis of the ROC curve in the pooled cohort shows an area under the curve of 0.88. Conclusion: This first-of-its-kind study suggests that a signature of arterial bloodflow in oHCM can be identified with the combination of a wristworn biosensor and machine learning algorithms. These data raise the possibility of a novel approach to the non-invasive detection of oHCM.