gebhart/patrepeval huggingface dataset:
Mechanistic investigation of reduction of daunomycin and 7-deoxydaunomycinone with bi(3,5,5-trimethyl-2-oxomorpholin-3-yl) (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic investigation of reduction of daunomycin and 7-deoxydaunomycinone with bi(3,5,5-trimethyl-2-oxomorpholin-3-yl)Don L. Kleyer and Tad H. KochCite this: J. Am. Chem. Soc. 1984, 106, 8, 2380–2387Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/ja00320a027https://doi.org/10.1021/ja00320a027research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An integrated system for concurrent design engineering (2002)

The authors describe a system that provides an integrated environment for product design and design evaluation. The system uses a feature-based design for assembly methodology, and serves as a decision and design aid for users interested in concurrent design. This is accomplished by integrating feature-based design with assembly analysis and assembly system synthesis. The authors illustrate how feature-based product models can serve as the base representation for assembly analysis and process design. Feature-based design captures design intent (assembly topology, product function, manufacturing, and field use) during the creation of part and product geometry. Design for assembly as used here extends existing ideas about critiquing part shapes and part count to include assembly process planning, assembly sequency generation, assembly fixturing assessments, and assembly process costs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Binding of soluble fibronectin and its subsequent incorporation into the extracellular matrix by early and late passage human skin fibroblasts. (1988)

The specific binding of soluble 125I-labeled human plasma fibronectin (125I-HFN-P) to confluent cultures of early and late passage human skin fibroblasts was investigated. Previous studies of HFN-P bound to fibroblast cell layers indicated that HFN-P was present in the cultures in two separate pools, distinguishable on the basis of their solubility in 1% deoxycholate. Pool I contained deoxycholate-soluble fibronectin (cell-associated), whereas Pool II contained deoxycholate-insoluble fibronectin (matrix-associated). Time course studies indicated that HFN-P was initially incorporated into Pool I and then accumulated into Pool II (McKeown-Longo, P.J., and Mosher, D.F. (1983) J. Cell Biol. 97, 466-472). Examination of the kinetics of 125I-HFN-P binding to Pool I of early and late passage cultures revealed that both cultures required 2-4 h to approach steady-state conditions. Other kinetic studies showed that the rates of loss of 125I-HFN-P from either Pool I or Pool II were similar for both cultures. However, the late passage cultures bound greater than twice as much fibronectin into Pool I, per cell, than the early passage cultures. This difference was not related to a difference in the level of endogenously produced fibronectins accumulating in the medium. Late passage cultures incorporated 125I-HFN-P into the deoxycholate-insoluble Pool at an average rate 2.6 times greater than early passage cultures. The late passage cultures also chased a greater percent of their Pool I-bound fibronectin into Pool II and a lower percent into the chase medium. These results indicate that early and late passage cultures of human fibroblasts exhibit differences in the binding of soluble fibronectin and in the extent to which they incorporate soluble fibronectin into the extracellular matrix.
Modeling and Measurement of Residual Stresses in a Forged IN718 Superalloy Disc (2004)

The residual stresses present in a quenched IN718 aeroengine compressor disc forging have been characterized using neutron diffraction and the results compared to those obtained from a finite element (FE) model for the quenching process. The ~40 kg forging had a diameter of ~400 mm and a maximum thickness of ~45mm. Neutron path lengths of up to 60 mm were required to record strain components at the deepest points within the material. The residual hoop and radial stresses measured are generally compressive at the surface, up to 600 MPa and tensile at depth, up to 400 MPa, whilst the radial stresses are generally small. The deviatoric stresses are generally <150 MPa. FE model predictions of the residual stress are reasonable agreement with the measured values.
Communication Cost of Simulating Bell Correlations (2003)

What classical resources are required to simulate quantum correlations? For the simplest and most important case of local projective measurements on an entangled Bell pair state, we show that exact simulation is possible using local hidden variables augmented by just one bit of classical communication. Certain quantum teleportation experiments, which teleport a single qubit, therefore admit a local hidden variables model.
Competitive Mechanisms forInhibition ofSulfate Reduction and Methane Production intheZoneofFerric Iron Reduction inSediments (1987)

process inhibited sulfate reduction 86to100%.The decrease inelectron flow tosulfate reduction wasaccompanied byacorresponding increase inelectron flowto Fe(III) reduction. Inasimilar manner, Fe(III) additions also inhibited methane production insulfate-depleted sediments. Theinhibition ofsulfate reduction andmethane production wastheresult ofsubstrate limitation, because thesediments retained thepotential forsulfate reduction andmethaneproduction inthepresence of excess hydrogen andacetate. Sediments inwhichFe(III) reduction wasthepredominant terminal electronaccepting process hadmuchlowerconcentrations ofhydrogen andacetate thansediments inwhichsulfate reduction ormethane production wasthepredominant terminal process. Thelowconcentrations ofhydrogen andacetate intheFe(III)-reducing sediments weretheresult ofmetabolism byFe(III)-reducing organisms of hydrogen andacetate atconcentrations lower thansulfate reducers ormethanogens couldmetabolize them. Theresults indicate thatwhenFe(III) isinaformthatFe(III)-reducing organisms canreadily reduce, Fe(III)-reducing organisms caninhibit sulfate reduction andmethaneproduction byoutcompeting sulfate reducers andmethanogens forelectron donors. Insight into themechanisms that control thedistribution of microbial redoxprocesses iscentral tounderstanding the geochemistry ofanaerobic aquatic environments. Threeof themostimportant redoxreactions innatural anaerobic environments aretheoxidation oforganic matter withthe reduction ofFe(III), theoxidation oforganic matter withthe reduction ofsulfate, andtheconversion oforganic matter to carbon dioxide andmethane (21, 22,28). Thesethree processes aregenerally considered mutually exclusive, withno sulfate reduction ormethane production until Fe(III) reduction iscomplete andnomethane production until sulfate is depleted (3,21,22,28). Therearethree majorsteps inthemetabolism oforganic matter insediments inwhichsulfate reduction ormethane production istheterminal electron-accepting
AcSDKP serum concentrations vary during chemotherapy in patients with acute myeloid leukaemia (1995)

AcSDKP is a physiological negative regulator of cell proliferation in mammals. In Ara-C-treated mice its plasmatic concentrations decrease while the CFU-S start cycling. Infusion of AcSDKP protects these animals from death by blocking the proliferation of primitive haemopoietic cells. We measured AcSDKP serum concentrations in 20 AML patients during the course of high-dose cytoreductive treatment. We observed an early and sharp increase of AcSDKP during the induction treatment in 12 patients, reaching a peak during the initial 3 d of treatment in nine of them. These results are contrary to those observed in mice treated with high doses of Ara-C. They encourage further clinical investigation, and suggest that treatments with synthetic AcSDKP (Seraspenide) will perhaps have to be adjusted to the type of disease and the schedule of chemotherapy in order to optimize its myeloprotective effect.
Clinical Characteristics of Hemophagocytic Lymphohistiocytosis Related to Kawasaki Disease (2011)

It is difficult to predict the prognosis or clinical course of secondary hemophagocytic lymphohistiocytosis (HLH) due to the various underlying causes. The authors analyzed the clinical and laboratory findings and outcomes in patients with HLH who had initially been diagnosed with Kawasaki disease (KD), and evaluated the clinical significance of each factor. Among the 21 patients with HLH, 5 had initially been diagnosed with KD and 16 had other etiologies. A comparative analysis was performed for fever duration, presence of cytopenia, serum ferritin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride, fibrinogen, hyponatremia, reactivation, and survival rate in those HLH patients associated with KD (group I) and other causes (group II). In patients in group I, a higher level of reactivation (20%), a lower survival rate (P = .001), higher AST (P = .031) and ferritin (P = .005), and frequent hyponatremia (P = .000) were found compared to patients in group II. Interestingly, patients in group I was older than the average of age of most KD patients. A high index of suspicion on the progression from KD to HLH would be mandatory when the KD patients show elevated AST and ferritin and the presence of hyponatremia, and especially so if the patient is of older age.
FAPRI 1999 World Agricultural Outlook (1999)

The Food and Agricultural Policy Research Institute (FAPRI) prepares a preliminary agricultural outlook on world agricultural production, consumption, and trade every fall. This is followed by an outside review, re-evaluation of projections, and completion of the final baseline in January. The FAPRI 2000 World Agricultural Outlook presents these final projections for world agricultural markets. A companion volume, the FAPRI 2000 U.S. Agricultural Outlook, presents the U.S. component of the baseline.
Immunochemical Localisation of Cathepsin S, Cathepsin L and MHC Class II-Associated p41 Isoform of Invariant Chain in Human Lymph Node Tissue (2001)

Article Immunochemical Localisation of Cathepsin S, Cathepsin L and MHC Class II-Associated p41 Isoform of Invariant Chain in Human Lymph Node Tissue was published on May 1, 2001 in the journal Biological Chemistry (volume 382, issue 5).
Relationship between histone H1 poly(adenosine diphosphate-ribosylation) and histone H1 phosphorylation using anti-poly(adenosine diphosphate-ribose) antibody (1983)

The chromatin-associated enzyme poly(ADP-Rib) polymerase catalyzes the posttranslational modification of histones. Antibody to poly(ADP-Rib) has been coupled to Sepharose, and the resultant immunoadsorbent was used to fractionate, specifically, histone H1 subpopulations undergoing this nuclear protein modification. When this method of separation was used, it was additionally observed that poly-(ADP-ribosylated) H1 species were highly accessible to in vitro phosphorylation by nuclear protein kinase. Phosphorylated H1 molecules were retained by the anti-poly(ADP-Rib)-Sepharose column due to the presence of endogenous poly-(ADP-Rib) components. Degradation of the latter moieties on phosphorylated H1 reversed their adsorption to the column.
Pressure dependence of the Raman modes and pressure-induced phase changes in CuGa<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">S</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>and AgGa<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">S</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1980)

The pressure dependence of the Raman peaks of CuGa${\mathrm{S}}_{2}$ and AgGa${\mathrm{S}}_{2}$ (chalcopyrite structure) has been studied up to 20 GPa in a gasketed diamond anvil cell. Nonlinear pressure dependence of several phonon frequencies have been noted, including a softening of the lowest ${\ensuremath{\Gamma}}_{5}$ phonon, prior to a phase transition, which takes place at 16.5\ifmmode\pm\else\textpm\fi{}0.5 GPa in CuGa${\mathrm{S}}_{2}$ and 4.2\ifmmode\pm\else\textpm\fi{}0.5 GPa in AgGa${\mathrm{S}}_{2}$. In the latter material, discontinuous changes of the Raman frequencies indicate another phase transition at 11.6\ifmmode\pm\else\textpm\fi{}0.5 GPa. The transition in CuGa${\mathrm{S}}_{2}$ is believed to be to the disordered rocksalt structure, and in AgGa${\mathrm{S}}_{2}$, the high-pressure transition is to the rocksalt, or to the closely related $\ensuremath{\alpha}$-NaFe${\mathrm{O}}_{2}$ structure. In AgGa${\mathrm{S}}_{2}$, the softening of the lowest ${\ensuremath{\Gamma}}_{5}$ phonons can be followed across the 4.2-GPa phase transition, an observation which to our knowledge has been made for the first time in a tetrahedral semiconductor. It is concluded that the first phase transition takes place in all these materials whenever the lowest ${\ensuremath{\Gamma}}_{5}$ mode (or its equivalent) is lowered to 0.7 times its zero-pressure value. The effect of pressure on the phonon frequencies is discussed in terms of Born's transverse dynamical charges and their pressure dependence.
‘Good governance’ can make bad government (2010)

This new collection critically examines the new global policy of 'good governance'. This catchphrase of aid policy and development thinking has been the subject of too little analysis to date. This book redresses the balance. It places the prefix 'good', and exactly what that means, under the microscope and examines the impact of neoliberal governance in a wide range of countries and territories, including Chile, Russia, Argentina and Indonesia.
Abstract 13344: Variable Factors Influence Restenosis Following Endovascular Therapy in the Superficial Femoral Artery: Comparison Between TASC II A-C and D lesions (2013)

Background: Endovascular therapy (EVT) by nitinol stenting is widely performed for femoropopliteal (FP) lesions in patients with peripheral artery disease (PAD). The latest European Society of Card...
Sensing turbulence transit time by pulsed ultrasound for single-phase fluid flow measurement (2002)

A new technique for sensing turbulence in single-phase fluid flow by pulsed ultrasound is developed. The velocity component of turbulence perpendicular to the flow axis is sensed by two ultrasonic transducers mounted diametrically opposite on the pipe. The technique facilitates detecting variations in time of flight of two ultrasonic pulses transmitted simultaneously in the opposite directions and perpendicular to the flow axis. The flow velocity is obtained from the position of the peak in the cross correlation function of the turbulence signals sensed at two locations on the pipe. A numerical simulation of the technique based on a theoretical model has been carried out. The technique has been implemented to measure volumetric flow noninvasively in a water circulation system with PVC pipes.
Towards automated service-oriented lifecycle management for 5G networks (2015)

5G networks will be a key enabler for the Internet of Things by providing a platform to connect a massive number of devices with heterogeneous sets of network quality requirements. In this environment, 5G network operators will have to solve the complex challenge of managing network services for diverse customer sectors (such as automotive, health or energy) with different requirements throughout their lifecycle. In this paper, we present current state of our work on automating part of the network service lifecycle management using knowledge management- and decision support techniques. We also present our ongoing implementation steps for such management function in 5G networks.
Fazit (2001)

Im Rahmen der vorliegenden Arbeit sind Möglichkeiten der Modellierung multipler Wettbewerbsreaktionen durch den Einsatz von Promotion-Instrumenten untersucht worden. Da der Einsatz von Promotion-Instrumenten unmittelbar, und häufig mit großer Wirkung, die Marktanteile und somit auch den Erfolg der Anbieter standardisierter Konsumgüter beeinflußt, erscheint er zur Analyse von Wettbewerbsinteraktionen besonders geeignet. Vor dem Hintergrund der durch die einschlägige Literatur belegten Defizite in der Forschung sind der gemeinsame Einsatz unterschiedlicher Instrumente im Sinne multipler Wettbewerbsreaktionen sowie die empirische Messung der Reaktionen anstelle konventioneller Gleichgewichtsanalysen in den Mittelpunkt der Arbeit gestellt worden. Aus der Wettbewerbsauffassung als ein dynamischer Prozeß der Interaktion konkurrierender Hersteller um die Gunst der Kunden für ihre Produkte resultierte die Notwendigkeit, diesem dynamischen Aspekt bei der Modellformulierung Rechnung zu tragen. Die wichtigsten Ergebnisse der vorliegenden Untersuchung werden im folgenden zusammengefaßt und zueinander in Beziehung gesetzt.
Impact of Depression and Psychosocial Treatment on Heart Rate Variability in Patients with Type 2 Diabetes Mellitus: An Exploratory Analysis Based on the HEIDIS Trial (2018)

Depression was not directly associated with cardiac autonomic control in this sample, but MBSR training may have positively influenced HR and HRV. In advanced diabetes, somatic and behavioral parameters seem to be more predictive than depression for the course of autonomic functioning, but the pathways remain unclear.
Letters to the Editor (2002)

In our recent article "Intimate partner violence among U.S. Army soldiers in Alaska: a comparison of reported rates and survey results" (Military Medicine 167(8):688-91) we suggested that it may not be appropriate to draw conclusions about serious intimate partner violence in the military based solely on the results of family conflict surveys.Despite elevated reported rates of spousal abuse at this Army post compared with other Army posts, self-reported intimate partner violence was the same as for the Army as a whole.,We proposed that this may be due to the likelihood that the most violent offenders are among the nonresponders to survey questionnaires.Additionally, violent offenders who do respond, may underreport their violence.
CHARACTERIZATION OF CONDENSED-PHASE CHEMICAL REACTIONS OF RDX AND NITRAMINE-BASED PROPELLANTS (1997)

A microprobe mass spectrometer was used to measure decomposition products from the subsurface region of two RDX-based propellants: XM39 and one (MZ) containing an energetic plasticizer. The microprobe was inserted into a hole drilled axially in the centerline of each propellant sample. Gaseous species released in the subsurface region were collected in the cavity and sucked into the probe and analyzed. Tests were conducted in Ar at 1 and 3 atm, with a CO2 laser external heat flux of 100, 200, and 275 W/cm2. An insignificant amount of solid-phase decomposition products was detected for MZ, and only a very minute amount of OST was detected from XM39 at very low heat flux conditions. At the time of bum through, the major species detected had masses of 30, 28,44, and 27 amu, believed to be CH2O, CO, N23O, and HCN. These products suggest that the RDX decomposition pathway to form CH2O and N2O is more dominant for the condensed-phase reactions at the operating conditions studied. The binders of these two propellants showed relatively inactive behavior under the conditions tested.
Development of Microwave-Assisted Drying Methods for Sample Preparation for Dried Spot Micro-X-ray Fluorescence Analysis (2002)

Although dried spot micro X-ray fluorescence (MXRF) is an effective analytical technique for trace elemental analysis, the sample preparation procedures currently used suffer from a number of drawbacks. These drawbacks include relatively long preparation times, lack of control of the sample preparation environment, and possibility of loss of volatile analytes during the drying process. Microwave-assisted drying offers several advantages for dried spot preparation, including control of the environment and minimized volatility because of the differences between microwave heating and conventional heating. A microwave-assisted drying technique has been evaluated for use in preparing dried spots for trace analysis. Two apparatus designs for microwave drying were constructed and tested using multielement standard solutions, a standard reference material, and a "real-world" semiconductor cleaning solution. Following microwave-assisted drying of these aqueous samples, the residues were redissolved and analyzed by ICPMS. Effective recovery was obtained using the microwave drying methods, demonstrating that the microwave drying apparatus and methods described here may be more efficient alternatives for dried spot sample preparation.
Contributions of Viruses and Immunity as Causes of Diabetes and Development of Strategies for Treatment and Prevention of Autoimmune Disease (2014)

This chapter introduces and explains the rat insulin promoter (RIP)-lymphocytic choriomeningitis virus (LCMV) model of vitally induced autoimmune diabetes. Special emphasis is given to the issues of molecular mimicry, the potential involvement of several viral infections in inducing or abrogating insulin-dependent diabetes mellitus (IDDM), new therapeutic perspectives, and pathogenically important findings that stem from the use of this model. The chapter discusses these issues, as well as other factors that precipitate or prevent IDDM. The RIP-LCMV transgenic mouse model differs in some important aspects from other established antigen-specific models of autoimmunity as well as from the nonobese diabetic (NOD) mouse model of spontaneous IDDM. The RIP-LCMV transgenic mouse model is ideally suited for the testing of novel approaches to antigen-specific immune therapy. The induction of IDDM by viral infection can be controlled and is directed to a known and well-characterized self-antigen, the LCMV transgene expressed by the B cells. Mice that expressed LCMV-NP as a transgene in their β cells developed IDDM after LCMV infection. Subsequent inoculation of plasmid DNA that encoded the insulin B chain reduced the incidence of this virally induced autoimmune diabetes by 50%. The protection provided by insulin B-chain DNA proceeded through induction of anti-self, regulatory CD4 lymphocytes that reacted with the insulin B chain, secreted IL-4, and locally reduced the activities of LCMV-NP autoreactive cytotoxic lymphocytes (CTLs) in the pancreatic draining lymph nodes.