gebhart/patrepeval huggingface dataset:
Backing Up Your Data to the Cloud: Want to Pay Less? (2013)

In this paper we present CAB, a Cost-Aware cloud Backup system, designed for users owning multiple connected devices. Putting client-side monetary cost reduction first, CAB allows users to access their data via multiple devices and applies file updates to the cloud backup with low time delay. We describe some of the optimizations necessary to achieve cost reduction, including data de-duplication, a log-structured data layout, garbage collection, and novel metadata management. Using two one-month long real-world traces, evaluation of a prototype implementation of CAB shows it reduces cost by 16 - 44% compared to a cost-oblivious baseline backup system. Our current prototype implementation stores data in Amazon S3, but is portable to different cloud providers that support REST protocol.
Wideband printed bowtie antenna element developmentfor post reception synthetic focusing surface penetrating radar (1999)

A printed bowtie antenna for a post-reception synthetic focusing surface penetrating radar (PRSF-SPR) has been developed with the aid of finite difference time domain analysis. Antenna free space characteristics were compared against practical measurements and the performance of the antenna was analysed when soil is present.
Model-based rendezvous calibration of mobile sensor networks for monitoring air quality (2015)

Mobile Wireless Sensor Networks (WSNs) hold the potential to constitute a real game changer for our understanding of urban air pollution, through a significant augmentation of spatial resolution in measurement. However, temporal drift, cross-sensitivity and effects caused by varying environmental conditions (e.g., temperature) in low-cost chemical sensors (typically used in mobile WSNs) pose a tough challenge for reliable calibration. Based on state-of-the-art rendezvous calibration methods, we propose a novel model-based method for automatically estimating the baseline and gain characteristics of low-cost chemical sensors taking temporal drift and temperature dependencies of the sensors into account. The performance of our algorithm is evaluated using data gathered by our long-term mobile sensor network deployment, developed within the Nano-Tera.ch OpenSense II project1 in Lausanne, Switzerland. We show that, in a realistic context of sparse and irregular rendezvous events, our method consistently improves rendezvous calibration performance for single-hop online calibration.
MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells (2012)

Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process in which a cell degrades its own long-lived proteins and damaged organelles. Ataxia telangiectasia mutated (ATM) has recently been shown to upregulate the process of autophagy. Previous studies showed that certain microRNAs, including miR-18a, potentially regulate ATM in cancer cells. However, the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells. In the present study, we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells. To determine whether a preliminary link exists between autophagy and miR-18a, HCT116 cells were irradiated and quantitative (q) PCR was performed to measure miR-18a expression. HCT116 cells were transfected with an miR-18a mimic to study its impact on indicators of autophagy. Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells. The results showed that miR-18a expression was strongly stimulated by radiation. Ectopic overexpression of miR-18a in HCT116 cell lines potently enhanced autophagy and ionizing radiation-induced autophagy. Moreover, miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity. Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development, progression, treatment and in other diseases.
Anthelmintic Quaternary Salts. Thiacyanines and Hemithiacyanines (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnthelmintic Quaternary Salts. Thiacyanines and HemithiacyaninesD. L. Garmaise, C. H. Chambers, J. Komlossy, and R. C. McCraeCite this: J. Med. Chem. 1967, 10, 5, 897–899Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/jm00317a031https://doi.org/10.1021/jm00317a031research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
'I Like you... as a Friend': The Role of Attraction in Cross-Sex Friendship (2000)

This study investigated attraction in heterosexual cross-sex friendships. Study I used in-depth interviews with 20 dyads (40 participants) to uncover four types of attraction that occur in cross-sex friendships - subjective physical/sexual attraction, objective physical/sexual attraction, romantic attraction, and friendship attraction. These types of attraction are subject to being symmetrical or asymmetrical, and may incur changes over time. Study 11 (N = 231) used a questionnaire to assess the frequency of each type of attraction and the frequency with which types of attraction are perceived to change. The most prevalent form of attraction was friendship attraction, and the least prevalent form was romantic attraction. The implications of these results for understanding both cross-sex friendships and the process of attraction are discussed.
Cooperative pull-push cycle for searching a hybrid P2P network (2004)

Information acquisition is a great challenge in the context of a continually growing Web. Nowadays, large Web search engines are primarily designed to assist an information pull by the user. On this platform, only actual information needs are handled without assistance of long-term needs. To overcome these shortcomings we propose a cooperative system for information pull and push on a peer-to-peer architecture. We present a hybrid network for a collaborative search environment, based on a local personalization strategy on each peer, and a highly-available Web search service (e.g. Google). Each peer participates in the pull-push cycle, and has the function of an information consumer as well as an information provider. Hence, long-term information needs can be identified without any context restrictions, and recommendations are computed based on virtual knowledge communities.
Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells (2012)

Phosphorylation of the histone variant H2AX forms γ-H2AX that marks DNA double-strand break (DSB). Here, we generated the sequencing-based maps of H2AX and γ-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endogenous and exogenous DSBs were identified based on γ-H2AX distribution in dividing cancer cells without irradiation and that in resting cells upon irradiation, respectively. γ-H2AX-enriched regions of endogenous origin in replicating cells included sub-telomeres and active transcription start sites, apparently reflecting replication- and transcription-mediated stress during rapid cell division. Surprisingly, H2AX itself, prior to phosphorylation, was specifically located at these endogenous hotspots. This phenomenon was only observed in dividing cancer cells but not in resting cells. Endogenous H2AX was concentrated on the transcription start site of actively transcribed genes but was irrelevant to pausing of RNA polymerase II (pol II), which precisely coincided with γ-H2AX of endogenous origin. γ-H2AX enrichment upon irradiation also coincided with actively transcribed regions, but unlike endogenous γ-H2AX, it extended into the gene body and was not specifically concentrated on the pausing site of pol II. Sub-telomeres were less responsive to external DNA damage than to endogenous stress. Our findings provide insight into DNA repair programs of cancer and may have implications for cancer therapy.
Phosphorus-31 and carbon-13 nuclear magnetic resonance studies of divalent cation binding to phosphatidylserine membranes: use of cobalt as a paramagnetic probe (1982)

The paramagnetic divalent cation cobalt has large and well-understood effects on NMR signals from ligands bound in the first coordination sphere, i.e., inner-sphere ligands, and we have used these effects to identify divalent cation binding sites at the surface of phosphatidylserine membranes. 31P NMR results show that 13% of the bound cobalt ions are involved in inner-sphere complexes with the phosphodiester group, while 13C NMR results show that 54% of the bound cobalt ions are involved in unidentate inner sphere complexes with the carboxyl group. No evidence is found for cobalt binding to the carbonyl groups, but proton release studies suggest that 32% of the bound cobalt ions are involved in chelate complexes that contain both the carboxyl and the amine groups. All (i.e., 13% + 54% + 32% = 99%) of the bound cobalt ions can thus be accounted for in terms of inner sphere complexes with the phosphodiester group or the carboxyl group. We suggest that the unidentate inner-sphere complex between cobalt and the carboxyl group of phosphatidylserine and the inner-sphere complex between cobalt and the phosphodiester group of phosphatidylserine provide reasonable models for complexes between alkaline earth cations and phosphatidylserine membranes.
Matrix method for analysis of selective NMR pulses (2005)

The evolution of a single nuclear magnetic spin during the application of radiofrequency (RF) pulses is followed using the 3 × 3 matrix solution to the Bloch equations. The effect of different pulses on the magnetization of spin-1/2 nuclei is described using this 3 × 3 matrix. Simulations of the magnetization following a simple square pulse, amplitude and amplitude/frequency modulated pulses are represented as unit vectors in the rotating reference frame, and evolution of the magnetization can be followed at any time during the application of the pulse. Projection of these vectors onto the transverse plane of the rotating frame of reference is the magnitude of the various components of detectable magnetization. From these simulations, the peak amplitude required to drive the RF power output of linear amplifiers can be calculated accurately and directly related to experiment. In addition, the magnitude of magnetization for a range of frequency offsets within an NMR spectrum can be simulated with or without phase cycling. The simulations of shaped and adiabatic pulses are described. The accuracy of these simulations were readily verified by experiment so that implementation of new pulses into pulse sequences could be assessed by simulation prior to application and reduce the use of spectrometer time for optimization of RF pulses in NMR pulse sequences. © 2005 Wiley Periodicals, Inc. Concepts Magn Reson Part A 25A: 1–17, 2005.
My Impressions of Qian Zhongshu (2005)

Editor-in-chief of Cultural Dialogue asked me to write something about my associations with Qian Zhongshu in his evening years. As it happens that I have just written a book on the same subject, here are some stories adapted from the book. I had heard of Qian Zhongshu long before I finally met him. In the mid 1950s when I studied at the Chinese Department of Beijing University,
Animal models of otitis media (1989)

Department of Otolaryngology, University of Pittsburgh School of Medicine, and Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh, Pittsburgh, PA.
Differential control of apoptosis by DJ‐1 in prostate benign and cancer cells (2004)

DJ-1 is a conserved protein reported to be involved in diverse cellular processes ranging from cellular transformation, control of protein-RNA interaction, oxidative stress response to control of male infertility, among several others. Mutations in the human gene have been shown to be associated with an autosomal recessive, early onset Parkinson's disease (PARK7). The present study examines the control of DJ-1 expression in prostatic benign hyperplasia (BPH-1) and cancer (PC-3) cell lines in which DJ-1 abundance differs significantly. We show that while BPH-1 cells exhibit low basal level of DJ-1 expression, stress-inducing agents such as H(2)O(2) and mitomycin C markedly increase the intracellular level of the polypeptide. In contrast, DJ-1 expression is relatively high in PC-3 cells, and incubation with the same cytotoxic drugs does not modulate further the level of the polypeptide. In correlation with the expression of DJ-1, both cytotoxic agents activate the apoptotic pathway in the prostatic benign cells but not in PC-3 cells, which are resistant to their action. We further demonstrate that incubation of BPH-1 cells with TNF-related-apoptosis-inducing-ligand/Apo-2L (TRAIL) also enhances DJ-1 expression and that TRAIL and H(2)O(2) act additively to stimulate DJ-1 accumulation but synergistically in the activation of the apoptotic pathway. Time-course analysis of DJ-1 stimulation shows that while DJ-1 level increases without significant lag in TRAIL-treated cells, there is a delay in H(2)O(2)-treated cells, and that the increase in DJ-1 abundance precedes the activation of apoptosis. Unexpectedly, over-expression of DJ-1 de-sensitizes BPH-1 cells to the action of apoptotic-inducing agents. However, RNA-interference-mediated silencing of DJ-1 expression results in sensitization of PC-3 cells to TRAIL action. These results are consistent with a model in which DJ-1 is involved in the control of cell death in prostate cell lines. DJ-1 appears to play a differential role between cells expressing a low but inducible level of DJ-1 (e.g., BPH-1 cells) and those expressing a high but constitutive level of the polypeptide (e.g., PC-3 cells).
Efficacy of inhaled tobramycin in the treatment of pulmonary exacerbations in children with cystic fibrosis (1983)

Two forms of treatment of acute pulmonary exacerbations in patients with cystic fibrosis were compared: intravenous ticarcillin (300 mg drug per kg per day) and tobramycin (10 mg drug per kg per day) versus the same intravenous antibiotic therapy plus inhaled tobramycin (80 mg three times per day). The 16 patients in the intravenous plus inhaled tobramycin group were similar to the 12 control patients in age, sex, Schwachman scores, pulmonary function and pretreatment colony counts of Pseudomonas aeruginosa in sputum. Treatment resulted in significant improvement in clinical status and pulmonary function without any apparent differences in the two groups. However, intravenous plus inhaled tobramycin resulted in temporary eradication of P. aeruginosa in 63% of the patients compared to 25% in the intravenous only group (P = 0.03). Suppression of P. aeruginosa in sputum cultures did not correlate with clinical response to treatment. No renal toxicity or elevations of serum tobramycin were observed in the intravenous plus inhaled tobramycin group.
Reduction of Motion Artifacts and Improvement of R Peak Detecting Accuracy Using Adjacent Non-Intrusive ECG Sensors (2016)

Non-intrusive electrocardiogram (ECG) monitoring has many advantages: easy to measure and apply in daily life. However, motion noise in the measured signal is the major problem of non-intrusive measurement. This paper proposes a method to reduce the noise and to detect the R peaks of ECG in a stable manner in a sitting arrangement using non-intrusive sensors. The method utilizes two capacitive ECG sensors (cECGs) to measure ECG, and another two cECGs located adjacent to the sensors for ECG are added to obtain the information on motion. Then, active noise cancellation technique and the motion information are used to reduce motion noise. To verify the proposed method, ECG was measured indoors and during driving, and the accuracy of the detected R peaks was compared. After applying the method, the sum of sensitivity and positive predictivity increased 8.39% on average and 26.26% maximally in the data. Based on the results, it was confirmed that the motion noise was reduced and that more reliable R peak positions could be obtained by the proposed method. The robustness of the new ECG measurement method will elicit benefits to various health care systems that require noninvasive heart rate or heart rate variability measurements.
68. Derivatives of monosilane. Part II. The iodo-compounds (1941)

H. J. Emeléus, A. G. Maddock and C. Reid, J. Chem. Soc., 1941, 353 DOI: 10.1039/JR9410000353
An ATM/TRIM37/NEMO Axis Counteracts Genotoxicity by Activating Nuclear-to-Cytoplasmic NF-κB Signaling (2018)

Blocking genotoxic stress-induced NF-κB activation would substantially enhance the anticancer efficiency of genotoxic chemotherapy. Unlike the well-established classical NF-κB pathway, the genotoxic agents-induced "nuclear-to-cytoplasmic" NF-κB pathway is initiated from the nucleus and transferred to the cytoplasm. However, the mechanism linking nuclear DNA damage signaling to cytoplasmic IKK activation remains unclear. Here, we report that TRIM37, a novel E3 ligase, plays a vital role in genotoxic activation of NF-κB via monoubiquitination of NEMO at K309 in the nucleus, consequently resulting in nuclear export of NEMO and IKK/NF-κB activation. Clinically, TRIM37 levels correlated positively with levels of activated NF-κB and expression of Bcl-xl and XIAP in esophageal cancer specimens, which also associated positively with clinical stage and tumor-node-metastasis classification and associated inversely with overall and relapse-free survival in patients with esophageal cancer. Overexpression of TRIM37 conferred resistance to the DNA-damaging anticancer drug cisplatin <i>in vitro</i> and <i>in vivo</i> through activation of the NF-κB pathway. Genotoxic stress-activated ATM kinase directly interacted with and phosphorylated TRIM37 in the cytoplasm, which induced translocation of TRIM37 into the nucleus, where it formed a complex with NEMO and TRAF6 via a TRAF6-binding motif (TBM). Importantly, blocking the ATM/TRIM37/NEMO axis via cell-penetrating TAT-TBM peptide abrogated genotoxic agent-induced NEMO monoubiquitination and NF-κB activity, resulting in hypersensitivity of cancer cells to genotoxic drugs. Collectively, our results unveil a pivotal role for TRIM37 in genotoxic stress and shed light on mechanisms of inducible chemotherapy resistance in cancer.<b>Significance:</b> In response to genotoxic stress, TRIM37 activates NF-κB signaling via monoubiquitination of NEMO, which subsequently promotes cisplatin chemoresistance and tumor relapse in cancer. <i>Cancer Res; 78(22); 6399-412. ©2018 AACR</i>.
Local premelting about impurities (1988)

X-ray-absorption fine-structure measurements were made on pure Pb and dilute solid solutions of Hg in Pb. These measurements are consistent with a model of local premelting of bonds around the Hg impurities beginning around 400 K, which is 180 \ifmmode^\circ\else\textdegree\fi{}C below the bulk melting temperature of the alloy. The results imply that initiation of bulk three-dimensional melting may occur around point defects, even for pure materials.
Depression in Women: Implications for Health Care Research (1995)

Epidemiologic data from around the world demonstrate that major depression is approximately twice as common in women than men and that its first onset peaks during the childbearing years. Progress has been made in understanding the epidemiology of depression and in developing effective treatments. Much remains to be learned about the basic pathogenesis of depression and the specific treatment needs of depressed women and their offspring, especially during the reproductive years.
Mechanical Behavior of High Temperature Hybrid Carbon Fiber/Titanium Laminates (2009)

The aim of this paper was to investigate the tensile and flexural properties of hybrid laminates made with titanium sheets and high modulus carbon fiber composites. Grade II titanium was used, which exhibits great high-temperature performance and creep resistance, low weight, and high strength. An inorganic fireproof matrix, known as geopolymer, was used to fabricate the high modulus carbon fiber composites. Previous studies have shown that these composites are strong, durable, lightweight, and can exhibit excellent performance up to 400°C. In the present study, a number of specimens were tested in uniaxial tension and four-point bending after exposure at elevated temperatures. The results indicate that the addition of carbon fibers can reduce the weight and increase the stiffness of the pure titanium. Moreover, the hybrid laminates are stronger and stiffer than the sum of the individual strengths and stiffnesses of the parent materials. An important finding is that the interlaminar bond is strong, and as a result no delamination failures were observed.
Thermodynamic Re‐Optimization of the Bi—In—Sn System Based on New Experimental Data. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
AVM modelling by multi-branching tube flow: large flow rates and dual solutions (2003)

Cerebral arteriovenous malformations (AVMs) present a common yet complex clinical challenge, through 'steal' phenomena, haemorrhage risks and epilepsy effects, aspects which are little understood even for individual lesions. The main difficulty lies in understanding the detailed haemodynamics of AVMs and especially the enhanced through-flow associated with steal. Mathematically, as a basic step, the paper investigates a nonlinear inviscid model for the planar incompressible flow of fluid through a branched geometry consisting of a single feeding mother tube which splits into two or more non-aligned daughter tubes. Recurrence relations between the unknown flow profiles in the daughter tubes and the incoming rotational flow profile in the mother tube are derived, analysed, and solved in detail in order to find the total flow rate. The results show greatly enhanced through-flow arising, for a fixed value of the total downstream flow area, either from non-unique solutions to the problem or more particularly from an increase in the number of daughter tubes, or from both, depending on the distribution of pressure differences applied across the branching region and the total downstream flow area. Extensions of the basic flow model are noted, along with comparisons with recent direct numerical simulations and discussion of possible repercussions in the context of treatment and clinical observations of enhanced through-flows in AVMs.