gebhart/patrepeval huggingface dataset:
Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples (2012)

Circulating tumor cells (CTC) are cells that disseminate from a primary tumor throughout the circulatory system and that can ultimately form secondary tumors at distant sites. CTC count can be used to follow disease progression based on the correlation between CTC concentration in blood and disease severity. As a treatment tool, CTC could be studied in the laboratory to develop personalized therapies. To this end, CTC isolation must cause no cellular damage, and contamination by other cell types, particularly leukocytes, must be avoided as much as possible. Many of the current techniques, including the sole FDA-approved device for CTC enumeration, destroy CTC as part of the isolation process (for more information see Ref. 2). A microfluidic device to capture viable CTC is described, consisting of a surface functionalized with E-selectin glycoprotein in addition to antibodies against epithelial markers. To enhance device performance a nanoparticle coating was applied consisting of halloysite nanotubes, an aluminosilicate nanoparticle harvested from clay. The E-selectin molecules provide a means to capture fast moving CTC that are pumped through the device, lending an advantage over alternative microfluidic devices wherein longer processing times are necessary to provide target cells with sufficient time to interact with a surface. The antibodies to epithelial targets provide CTC-specificity to the device, as well as provide a readily adjustable parameter to tune isolation. Finally, the halloysite nanotube coating allows significantly enhanced isolation compared to other techniques by helping to capture fast moving cells, providing increased surface area for protein adsorption, and repelling contaminating leukocytes. This device is produced by a straightforward technique using off-the-shelf materials, and has been successfully used to capture cancer cells from the blood of metastatic cancer patients. Captured cells are maintained for up to 15 days in culture following isolation, and these samples typically consist of >50% viable primary cancer cells from each patient. This device has been used to capture viable CTC from both diluted whole blood and buffy coat samples. Ultimately, we present a technique with functionality in a clinical setting to develop personalized cancer therapies.
"Leapfrog" methods for numerical solution of differential equations, sinewave generation, and magnitude approximation (2002)

Numerical integration by alternating updates between two variables-the "leapfrog" technique-has remarkably useful properties, which we trace across three widely different applications. For a dynamic physical system, alternation of position and velocity updates helps us to contrive a second-order numerical integration method twice as accurate as the more complex predictor-corrector method. Next, we specialize this method to get a simple incremental sine-cosine waveform generator which is exact except for rounding-error accumulation and competitive with Bresenham (1965) type generators for graphics applications. Finally, me further adapt the waveform generator to serve as a generalized vector-magnitude-approximation method which includes one of the best "two-line" methods as a special case.
The procedure for monitoring and maintaining a network of distributed resources (2014)

In this article, we propose an algorithm for the management of the structure of the tunnel connections in large, distributed nature, corporate network. Management is here understood as monitoring the availability and health of key elements and dynamic reconfiguring the system in situations of failure symptoms. It was assumed that the algorithm can be used in cases where the correct functioning of the network (providing the appropriate level of quality of service) means an access to distributed resources, usually redundant, which may be subject to reallocation. It was shown that developed algorithm may be used for maintenance of VPN network with dynamic tunnels (DMVPN).
Condensed thiophen ring systems. Part X. Synthesis and reactions of 2-aryl-1H-[1]benzothieno[2,3-b]pyrroles and 2-aryl-1H-[1]benzothieno[3,2-b]pyrroles (1973)

Reductive cyclisation of a trans-1-aryl-2-(3-nitro-2-benzo[b]thienyl)- or a trans-1-aryl-2-(2-nitro-3-benzo[b]-thienyl)-ethene, respectively, with triethyl phosphite gave the title compounds. The trans-alkenes were prepared by the Wittig reaction from 3-nitrobenzo[b]thiophen-2-carbaldehyde or 2-nitrobenzo[b]thiophen-3-carbaldehyde, respectively. Improved methods for the preparation of these aldehydes are reported, together with some electrophilic substitution reactions of 2-phenyl-1H,-[1]benzothieno[3,2-b]pyrrole.
A TALE OF THREE WEB SITES (1996)

Spinning a strategy? Marketing, image, and awareness all have a place on the Web.
Short-term inhibition of the energy metabolism affects motility but not surface properties of sperm cells (1996)

Centrifugal countercurrent distribution (CCCD) in aqueous two-phase systems has been proven to be a useful method to study subtle surface properties of spermatozoa. The present work shows that a short-term inhibition of the energy metabolism of sperm cells effected by incubating bovine sperm cells with KCN or ouabain, did not account for changes in the cell surface properties, as assessed either by estimation of the cell viability or by CCCD analysis. However, the short-term inhibition of energy metabolism provoked a clear decrease of cell motility, suggesting that a drop of cellular ATP levels brings about a rapid decrease of motility followed by a very delayed effect on cell surface properties. The relevance of these results on the handling of sperm and on the understanding of the molecular events underlying asthenospermia is discussed.
EFFECT OF THE SECOND PHASE ON CRITICAL CURRENT DENSITY IN Nb-ADDED YBCO FILMS (1995)

Thin films of YBCO with or without Nb added were prepared on (100) ZrO 2 single crystalline substrate by dc magnetron sputtering method. A phase of YBa 2 NbO 6 was found to form not only in the target materials of YBCO but also in the sputtered thin films. The second phase of YBa 2 NbO 6 in the superconducting films destroyed a match relation between the lattice of YBCO and the lattice of ZrO 2 substrate. The measurements of critical current density J c under magnetic field (H // c axis, up to 5T) showed that the J c in Nb-added YBCO films reduced more apparently than that in YBCO films. It is concluded that the existence of second phase of YBa 2 NbO 6 in superconducting phase does not play a rule of flux pinning.
Igf1 promotes longitudinal bone growth by insulin‐like actions augmenting chondrocyte hypertrophy (1999)

Longitudinal bone growth, and hence stature, are functions of growth plate chondrocyte proliferation and hypertrophy. Insulin-like growth factor 1 (Igf1) is reputed to augment longitudinal bone growth by stimulating growth plate chondrocyte proliferation. In this study, however, we demonstrate that chondrocyte numbers and proliferation are normal in Igf1 null mice despite a 35% reduction in the rate of long bone growth. Igf1 null hypertrophic chondrocytes differentiate normally in terms of expressing specialized proteins such as collagen X and alkaline phosphatase, but are smaller than wild-type at all levels of the hypertrophic zone. The terminal hypertrophic chondrocytes, which form the scaffold on which long bone growth extends, are reduced in linear dimension by 30% in Igf1 null mice, accounting for most of their decreased longitudinal growth. The expression of the insulin-sensitive glucose transporter, GLUT4, is significantly decreased and the insulin-regulated enzyme glycogen synthase kinase 3beta (GSK3) is hypo-phosphorylated in Igf1 null chondrocytes. Glycogen levels were significantly decreased and ribosomal RNA levels were reduced by almost 75% in Igf1 null chondrocytes. These data suggest that Igf1 promotes longitudinal bone growth by 'insulin-like' anabolic actions which augment chondrocyte hypertrophy.
El arrepentimiento en el delito de tráfico de drogas: artículo 376 del Código Penal (2012)

Razones politico-criminales de utilidad contra la delincuencia organizada han justificado el establecimiento de un «premio» o perdon como contra contraprestacion por una conducta del culpable confeso colaborador con las autoridades que consiste en la disminucion de los efectos punitivos. Dicha decision de rebajar la pena en uno o dos grados en absolutamente facultativa por parte del Tribunal. Se analiza de manera exhaustiva otros mecanismos de atenuacion de la pena como son la aplicacion de las circunstancias atenuantes de los nums. 4, 5 y 6 del articulo 21 del Codigo Penal.
Mechanisms of Bacillus subtilis spore resistance to and killing by aqueous ozone (2004)

These results provide information on the mechanisms of spore killing by and resistance to ozone.
Differential Accumulation of Antioxidant mRNAs in Arabidopsis thaliana Exposed to Ozone (1995)

Antioxidant isoenzymes function to eliminate free radicals and are localized to several different subcellular compartments within the plant cell. In Arabidopsis thaliana exposed to ozone (O3), we have monitored the accumulation of mRNAs encoding both cytosolic and chloroplastic antioxidant isoenzymes. Two different O3 exposure protocols yielded similar results. Upon O3 exposure, the steady-state levels of three mRNAs encoding cytosolic antioxidant isoenzymes (ascorbate peroxidase, copper/zinc superoxide dismutase, and glutathione S-transferase) increase. The glutathione S-transferase mRNA responds very quickly to the oxidative stress (2-fold increase in 30 min) and is elevated to very high levels, especially in plants grown with a 16-h photoperiod. In contrast, O3 exposure causes a decline in the levels of two chloroplastic antioxidant mRNAs (iron superoxide dismutase and glutathione reductase) and two photosynthetic protein mRNAs (chlorophyll a/b-binding protein and ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit). We show that this decline does not include all mRNAs encoding chloroplast-targeted proteins, since O3 causes an elevation of mRNA encoding the chloroplast-localized tryptophan biosynthetic enzyme phosphoribosylanthranilate transferase. Two alternative hypotheses that could explain this differential mRNA accumulation in response to O3 are discussed.
Application of a universal force field to metal complexes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of a universal force field to metal complexesA. K. Rappe, K. S. Colwell, and C. J. CasewitCite this: Inorg. Chem. 1993, 32, 16, 3438–3450Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://doi.org/10.1021/ic00068a012RIGHTS & PERMISSIONSArticle Views2146Altmetric-Citations380LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
A profile-based hierarchical location management scheme for future PCS (2002)

To accommodate the growth in the user population and network size in mobile environments, hierarchical architectures of location databases have been proposed. Recent studies showed that the signaling traffic and processing overhead of location updates is expected to grow tremendously, leading to poor performance. The authors present a Profile based Hierarchical location management Scheme (PHS) that focuses on reducing the cost of updates while keeping the lookup cost low. Our proposal is motivated by the observation that users follow repetitive patterns that can be profiled and predicted with reasonable cost, allowing users to send updates occasionally and not on every move. Further, it deploys a simple prediction technique that reduces the uncertainty of a user's location. We quantify the costs and benefits of PHS for several mobility patterns and show that it can result in up to 60% reduction in the update cost with minimal increase (7%) in lookup cost.
My Other Sister (1975)

In lieu of an abstract, below is the essay's first paragraph. know it's my fault, but if it wasn't for my dumb other sister Julie and stupid Matt Hayney it never would have happened. Julie's sixteen and because I'm thirteen she thinks it's all right to say I'm a sissy because I don't smoke or because I don't sleep with my mouth open on the school bus like her boyfriend Harry does. She teases me, too, because sometimes I get nervous when people make fun of me and once I had to go to the doctor about it. Even if he's a couple years older than me, I wanted Julie to like me so I hung around with Matt for a while. A lot of people didn't like him because he went to vocational school and stole a car once, but I didn't care because Julie said he was O.K. Cover Page Footnote Appeared in the issue: 1975. This prose is available in The Angle: http://fisherpub.sjfc.edu/angle/vol1975/iss1/9
Hesperidin Upregulates Heme Oxygenase-1 To Attenuate Hydrogen Peroxide-Induced Cell Damage in Hepatic L02 Cells (2010)

Hesperidin, a naturally occurring flavonoid presents in fruits and vegetables, has been reported to exert a wide range of pharmacological effects that include antioxidant, anti-inflammatory, antihypercholesterolemic, and anticarcinogenic actions. However, the cytoprotection and mechanism of hesperidin to neutralize oxidative stress in human hepatic L02 cells remain unclear. In this work, we assessed the capability of hesperidin to attenuate hydrogen peroxide (H(2)O(2))-induced cell damage by augmenting the cellular antioxidant defense. Real-time quantitative polymerase chain reaction, Western blot, and enzyme activity assay demonstrated that hesperidin upregulated heme oxygenase-1 (HO-1) expression to protect hepatocytes against oxidative stress. In addition, hesperidin also promoted nuclear translocation of nuclear factor erythroid 2-related factor (Nrf2). What's more, hesperidin exhibited activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2). Besides, ERK1/2 inhibitor significantly inhibited hesperidin-mediated HO-1 upregulation and Nrf2 nuclear translocation. Taken together, the above findings suggested that hesperidin augmented cellular antioxidant defense capacity through the induction of HO-1 via ERK/Nrf2 signaling. Therefore, hesperidin has potential as a therapeutic agent in the treatment of oxidative stress-related hepatocyte injury and liver dysfunctions.
Virtual memory (2003)

Virtual memory is the simulation of a storage space so large that programmers do not need to reprogram or recompile their works when the capacity of a local memory or the configuration of a network changes. The name, borrowed from optics, recalls the virtual images formed by mirrors and lenses--images that are not there but behave as if they are. The designers of the Atlas Computer at the University of Manchester invented virtual memory in the 1950s to eliminate a looming programming problem: planning and scheduling data transfers between main and secondary memory and recompiling programs for each change of size of main memory. Virtual memory is even more useful in the computers of the 1990s, which have more things to hide-on-chip caches, separate RAM chips, local disk storage, network file servers (q.v.), large numbers of separately compiled program modules, other computers on the local bus or local network, or the Internet. The story of virtual memory from then to now is a story about machines helping programmers solve problems in storage allocation, protection of information, sharing and reuse of objects, and linking of program components. Virtual memory, common in all computers and operating systems from the smallest microprocessor to the largest supercomputer, is now invading the Internet.
Detailed Mapping of the Nuclear Export Signal in the Rous Sarcoma Virus Gag Protein (2005)

The Rous sarcoma virus (RSV) Gag polyprotein undergoes transient nuclear trafficking as an intrinsic part of the virus assembly pathway. Nuclear export of Gag is crucial for the efficient production of viral particles and is accomplished through the action of a leptomycin B (LMB)-dependent nuclear export signal (NES) in the p10 domain (L. Z. Scheifele, R. A. Garbitt, J. D. Rhoads, and L. J. Parent, Proc. Natl. Acad. Sci. USA 99:3944-3949, 2002). We have now mapped the nuclear export activity to the C-terminal portion of the p10 sequence and identified the four hydrophobic amino acids within this region that comprise a leucine-rich NES. Alteration of these hydrophobic residues resulted in the accumulation of Gag proteins within the nucleus and a budding defect greater than that obtained with LMB treatment of cells expressing the wild-type Gag protein (Scheifele et al., Proc. Natl. Acad. Sci. USA 99:3944-3949, 2002). In addition, export of Gag from the nucleus was found to be a rate-limiting step in virus-like particle production. Consistent with a role for the NES sequence in viral replication, this cluster of hydrophobic residues in p10 is conserved across a wide range of avian retroviruses. Furthermore, naturally occurring substitutions within this region in related viruses maintained nuclear export activity and remained sensitive to the activity of LMB. Using gain-of-function approaches, we found that the hydrophobic motif in p10 was sufficient to promote the nuclear export of a heterologous protein and was positionally independent within the Gag polyprotein. Finally, the export pathway was further defined by the ability of specific nucleoporin inhibitors to prevent the egress of Gag from the nucleus, thereby identifying additional cellular mediators of RSV replication.
Effects of ambient temperature on the capacity to perform prolonged cycle exercise in man (1997)

Eight healthy males performed four rides to exhaustion at approximately 70% of their VO2max obtained in a neutral environment. Subjects cycled at ambient temperatures (Ta) of 3.6 +/- 0.3 (SD), 10.5 +/- 0.5, 20.6 +/- 0.2, and 30.5 +/- 0.2 degrees C with a relative humidity of 70 +/- 2% and an air velocity of approximately 0.7 m.s-1. Weighted mean skin temperature (Tsk), rectal temperature (Tre), and heart rate (HR) were recorded at rest, during exercise and at exhaustion. Venous samples were drawn before and during exercise and at exhaustion for determination of hemoglobin, hematocrit, blood metabolites, and serum electrolytes and osmolality. Expired air was collected for calculation of VO2 and R which were used to estimate rates of fuel oxidation. Ratings of perceived exertion (RPE) were also obtained. Time to exhaustion was significantly influenced by Ta (P = 0.001): exercise duration was shortest at 30.5 degrees C (51.6 +/- 3.7 min) and longest at 10.5 degrees C (93.5 +/- 6.2 min). Significant effects of Ta were also observed on VE, VO2, R, estimated fuel oxidation, HR, Tre, Tsk, sweat rate, and RPE. This study demonstrates that there is a clear effect of temperature on exercise capacity which appears to follow an inverted U relationship.
Real-time Face Tracking (2006)

Face detection and recognition has been a widely researched topic due to its high application value in various fields and industries, such as biometrics, image retrieval. Recently face recognition has also been deployed to aid in counter-terrorism by recognizing hardcore criminals and terrorist in the important installations. In this paper, we present an approach to the real-time detection and recognition of human faces, and the tracking of the face. We have also modified the approach to allow for situations when the face cannot be detected, and we will then track the motion under changing background in real-time. Our approach uses the cascade architecture for face detection proposed by Viola and Jones which uses a feature selection algorithm based on AdaBoost. This architecture has been incorporated into the existing OpenCV library. As for face recognition, we will use ARENA, a simple, memory-based algorithm for face recognition. Due to the rapidly changing background during tracking, we will be using a modified background subtraction method which can adapt robustly and detect the motion. A Canon-VCC4 pan/tilt/zoom camera will be employed to track the face and the motion. Subject Descriptors:
Nominations for officers 1980–1982 (1979)

Members of AGU are invited to submit additional nominees by petition in accordance with the bylaws. Each petition must be signed by at least 1% of the voting members of the Union or section, as the case may be, and such petitions must be received by the General Secretary by November 30,1979. The number of names required to make a petition nomination is as follows: Union, 122; Geodesy, 5; Geomagnetism and Paleomagnetism, 12; Hydrology, 10; Meteorology, 7; Oceanography, 16; Planetology, 11; Seismology, 22; Solar‐Planetary Relationships, 10; Tectonophysics, 7; and Volcanology, Geochemistry, and Petrology, 15.
Cryodamage to plasma membrane integrity in head and tail regions of human sperm. (2000)

(1) The HOS-EY test has the advantage of showing four patterns of membrane integrity in individual spermatozoon; (2) Cryopreservation causes a significant membrane rupture in the head and tail regions of spermatozoa; Type III is the main transitional state of membrane cryodamage; (3) Cryodamage to head and tail membrane may occur independently; the presence of an intact tail membrane does not necessarily indicate the intactness of head membrane. (4) Intact membranes are closely related to post-thaw motility, but do not reflect the fertilizing potential.
Djeme/Western Thebes (2018)

Abstract The village of Djeme was the principal settlement site in western Thebes, after which the local region was referred to as the Holy Mount of Djeme. The large body of Coptic textual evidence from the site, together with what survived of its archaeology, makes it one of the best‐known sites in Late Antique and early Islamic Egypt and its evidence is invaluable for reconstructing the daily life of Egypt's village population at this time.
GMSK/DS spread-spectrum signaling with two-bit differential detection over mobile channels with frequency-selective fading (2002)

The performance of GMSK/DS spread-spectrum signaling with binary phase-shift-keying and two-bit differential detection operating in a fast Rayleigh frequency dispersive mobile channel is investigated. A generalized channel model, that takes into consideration the presence of faded cochannel interference signals, is used for analysis. Closed form expressions are derived for the average error probability and are numerically evaluated for many channel conditions. The results clearly show that the incorporation of DS signaling, with relatively small processing gain, highly improves the performance of GMSK in severe channel degradation environments.