gebhart/patrepeval huggingface dataset:
First-pass Lung Uptake and Pulmonary Clearance of Propofol  (1999)

Recirculatory modeling of ICG allows modeling of the first-pass pulmonary kinetics of propofol concurrently. Propofol undergoes extensive uptake and first-pass elimination in the lungs.
In Vitro Aging of Yttria‐Stabilized Zirconia (1989)

Yttria‐stabilized zirconia was aged in distilled water, saline, and Ringer's solution for 140, 304, and 453 d. The significant decreases in strength (13% to 22%) is attributed to the phase transformation of zirconia from tetragonal to monoclinic. The effect of aging stabilized zirconia in physiological media is still unresolved.
Complement Inhibitor Factor H Binding to Lyme Disease Spirochetes Is Mediated by Inducible Expression of Multiple Plasmid-Encoded Outer Surface Protein E Paralogs (2002)

Borrelia burgdorferi spirochetes can circumvent the vertebrate host's immune system for long periods of time. B. burgdorferi sensu stricto and B. afzelii, but not B. garinii, bind the complement inhibitor factor H to protect themselves against complement-mediated opsonophagocytosis and killing. We found that factor H binding and complement resistance are due to inducible expression of a wide repertoire of outer surface protein E (OspE) lipoproteins variably called OspE, p21, ErpA, and ErpP. Individual Borrelia strains carry multiple plasmid-encoded OspE paralogs. Together the OspE homologs were found to constitute an array of proteins that bind factor H via multiple C-terminal domains that are exposed outwards from the Borrelial surface. Charged residue substitutions in the key binding regions account for variations between OspE family members in the optimal binding pH, temperature, and ionic strength. This may help the spirochetes to adapt into various host environments. Our finding that multiple plasmid-encoded OspE proteins act as virulence factors of Borrelia can provide new tools for the prevention and treatment of borreliosis.
A permanent arterial access system. (1989)

Now that long-term survival can be achieved in animals with mechanical circulatory devices, reliable permanent arterial access for physiologic and pharmacologic studies has become important. A novel approach has been developed eliminating the need for repeated arterial cannulation. The arterial access system (AAS) consists of a 7 Fr Silastic catheter, which is threaded into the internal mammary artery, and an attached access well, which is placed in the subcutaneous tissue over the sixth rib. The AAS is implanted during the initial operation. The access well is punctured percutaneously with a 23 gauge needle to obtain arterial blood or to measure arterial pressure, and patency is maintained by flushing the access well with 2,000 U of heparin each week. The AAS was implanted in six calves (three with a total artificial heart, three with a ventricular assist device) for a mean duration of 124 days (range, 20-323 days). There were no infections related to the AAS, and none of them thrombosed. All of the AAS had excellent arterial wave forms when punctured. The AAS is simple to implant, provides reliable long-term arterial access, and does not appear to increase the risk of infection.
Upstream suprathermal ions (1985)

This chapter contains sections titled: Introduction Upstream Suprathermal Ion Populations and Their Associated Waves Origins Interplanetary Shocks Summary Conclusion
Making the DDA run: two-dimensional ray traversal using runs and runs of runs (2001)

Iterative algorithms based on runs, and runs of runs are presented to calculate the cells of the two-dimensional lattice intersected by a line of real slope and intercept. The technique is applied to the problem of traversing a ray through a two-dimensional grid. Using runs or runs of runs provides a significant improvement in the efficiency of ray traversal for all but very short path lengths when compared to the DDA algorithm implemented using floating or fixed point arithmetic.
Robust tracking using local sparse appearance model and K-selection (2011)

Online learned tracking is widely used for it's adaptive ability to handle appearance changes. However, it introduces potential drifting problems due to the accumulation of errors during the self-updating, especially for occluded scenarios. The recent literature demonstrates that appropriate combinations of trackers can help balance stability and flexibility requirements. We have developed a robust tracking algorithm using a local sparse appearance model (SPT). A static sparse dictionary and a dynamically online updated basis distribution model the target appearance. A novel sparse representation-based voting map and sparse constraint regularized mean-shift support the robust object tracking. Besides these contributions, we also introduce a new dictionary learning algorithm with a locally constrained sparse representation, called K-Selection. Based on a set of comprehensive experiments, our algorithm has demonstrated better performance than alternatives reported in the recent literature.
TV Newscasts (1975)

(Below are few excerpts from a Bibliographic Essay by William Miller which totalled 33 double-spaced typed pages when submitted to the University of Toronto's Faculty of Library Science under the title, "Television Broadcasting of News in Canada, Great Britain, and the United States." Other excerpts may be printed in future issues. The article that follows this excerpt, "Canadian TV Coverage of World Events" is not part of the essay, it was written for Media Probe.)
Amino acid composition and subunit structure. Human placental 17β-estradiol dehydrogenase (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmino acid composition and subunit structure. Human placental 17β-estradiol dehydrogenaseDonald J. W. Burns, Lewis L. Engel, and John L. BethuneCite this: Biochemistry 1972, 11, 14, 2699–2703Publication Date (Print):July 1, 1972Publication History Published online1 May 2002Published inissue 1 July 1972https://pubs.acs.org/doi/10.1021/bi00764a023https://doi.org/10.1021/bi00764a023research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
장애인 고용에 있어 적극적 우대정책의 개선방안 연구 (2004)

본 연구는 공공분야의 장애인 적극적 우대정책을 UN, ILO등 국제기구의 권고와 협약, 외국의 정책과 비교·분석하여 개선방안을 마련하고자 한 연구로서 연구에서 나타난 결과는 한국의 공공분야 적극적 우대정책은 적용대상범위나 기준고용율, 관련법률의 지원 등에 있어서 많은 문제점을 가지는 것으로 나타났으며, 이를 개선하기 위한 방안은 적용대상자의 범위를 확대해야...
Manufacturability estimates for optical aspheres (2011)

Some simple measures of the difficulty of a variety of steps in asphere fabrication are defined by reference to fundamental geometric considerations. It is shown that effective approximations can then be exploited when an asphere's shape is characterized by using a particular orthogonal basis. The efficiency of the results allows them to be used not only as quick manufacturability estimates at the production end, but more importantly as part of an efficient design process that can boost the resulting optical systems' cost-effectiveness.
Influence of the preparation methods on the drug release behaviour of loperamide-loaded nanoparticles (1998)

Polylactide (PLA) or poly(lactide-coglycolide) (PLGA) nanoparticles containing loperamide (LPM) were prepared by an incorporation or adsorption method with the objective of developing nanoparticles with a rapid drug release. The use of polymers such as PLA with lower molecular weights and the addition of sorbitan fatty acid esters (SFAE) for the incorporation led to an almost complete entrapment of LPM in nanoparticles. Preparation of PLA nanoparticles by adsorption was performed by addition of LPM methanol solution before, during and after evaporation of dichloromethane from the system. The adsorption of LPM onto the nanoparticles with low molecular weight PLA (m.w. 2000) showed an isotherm with a good correlation to the Langmuir equation. A high amount of LPM can be entrapped or adsorbed in nanoparticles only with low molecular weights of PLA or PLGA. In the incorporation method, the addition of SFAEs increased drug entrapment. However, in the adsorption method they had no effect on nanoparticle drug adsorption. The drug-release profiles from both nanoparticles, prepared by the adsorption and incorporation methods, were biphasic with an initial rapid release and a second slower release phase, although their initial extents of release were different. The release rates were almost the same for both the adsorption and incorporation method without SFAEs. The addition of SFAEs to the adsorption system increased the extent of drug release from nanoparticles. In conclusion, a rapid loperamide release from nanoparticles can be achieved by use of PLA or PLGA with low molecular weights and in the adsorption method by the addition of SFAEs.
Limitations of the Case-only Design for Identifying Gene-Environment Interactions (2001)

The case-only design, which requires only diseased subjects, allows for estimation of multiplicative interactions between factors known to be independent in the study population. The design is being used as an alternative to the case-control design to study gene-environment interactions. Estimates of gene-environment interactions have been shown to be very efficient relative to estimates obtained with a case-control study under the assumption of independence between the genetic and environmental factors. In this paper, the authors explore the robustness of this procedure to uncertainty about the independence assumption. By using simulations, they demonstrate that inferences about the multiplicative interaction with the case-only design can be highly distorted when there is departure from the independence assumption. They illustrate their results with a recent study of gene-environment interactions and risk of lung cancer incidence in a cohort of miners from the Yunnan Tin Corporation in southern China. Investigators should be aware that the increased efficiency of the case-only design is a consequence of a strong assumption and that this design can perform poorly if the assumption is violated.
Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways (2019)

Hepatocellular carcinoma (HCC) is the most prevalent type of malignant liver disease worldwide. Molecular changes in HCC collectively contribute to Wnt/β-catenin, as a tumor proliferative signaling pathway, toll-like receptors (TLRs), nuclear factor-kappa B (NF-κB), as well as the c-Jun NH2-terminal kinase (JNK), predominant signaling pathways linked to the release of tumor-promoting cytokines. It should also be noted that the Hippo signaling pathway plays an important role in organ size control, particularly in promoting tumorigenesis and HCC development. Nowadays, mesenchymal stromal cells (MSCs)-based therapies have been the subject of in vitro, in vivo, and clinical studies for liver such as cirrhosis, liver failure, and HCC. At present, despite the importance of basic molecular pathways of malignancies, limited information has been obtained on this background. Therefore, it can be difficult to determine the true concept of interactions between MSCs and tumor cells. What is known, these cells could migrate toward tumor sites so apply effects via paracrine interaction on HCC cells. For example, one of the inhibitory effects of MSCs is the overexpression of dickkopf-related protein 1 (DKK-1) as an important antagonist of the Wnt signaling pathway. A growing body of research challenging the therapeutic roles of MSCs through the secretion of various trophic factors in HCC. This review illustrates the complex behavior of MSCs and precisely how their inhibitory signals interface with HCC tumor cells.
Organoboron Compounds, and the Study of Reaction Mechanisms. Primary Aliphatic Boronic Acids<sup>1</sup> (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganoboron Compounds, and the Study of Reaction Mechanisms. Primary Aliphatic Boronic Acids1H. R. Snyder, J. A. Kuck, and John R. JohnsonCite this: J. Am. Chem. Soc. 1938, 60, 1, 105–111Publication Date (Print):January 1, 1938Publication History Published online1 May 2002Published inissue 1 January 1938https://doi.org/10.1021/ja01268a033RIGHTS & PERMISSIONSArticle Views2069Altmetric-Citations122LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (875 KB) Get e-Alerts Get e-Alerts
A Randomized, Double-Blind, Crossover Study of Methylphenidate and Lithium in Adults With Attention-Deficit/Hyperactivity Disorder: Preliminary Findings (2002)

The authors examined the efficacy of methylphenidate (MPH) and lithium to treat attention-deficit/ hyperactivity disorder (ADHD) in adults, using a randomized, double-blind, crossover design. Patients received 8 weeks of MPH treatment (up to 40 mg/day) and 8 weeks of lithium treatment (up to 1,200 mg/day), by random assignment. Independent evaluators blind to group assignment assessed response every 2 weeks and at the end of each phase. The primary outcome measure was the Conners' Adult ADHD Rating Scale sum score for the clusters of hyperactivity, impulsivity, and learning problems. Secondary outcome measures were scores of irritability, overt aggression, antisocial behavior, anxiety, and depression, and scores on tests of verbal learning and sustained attention. In this preliminary study, lithium and MPH produced similar improvements on the primary outcome measure and on measures of irritability, aggressive outbursts, antisocial behavior, anxiety, and depression.
Efficient self-healing group key distribution with revocation capability (2003)

This paper presents group key distribution techniques for large and dynamic groups over unreliable channels. The techniques proposed here are based on the self-healing key distribution methods (with revocation capability) recently developed by Staddon et al. [27]. By introducing a novel personal key distribution technique, this paper reduces (1) the communication overhead of personal key share distribution from O(t2log q) to O(tlogq), (2) the communication overhead of self-healing key distribution with t-revocation capability from O((mt2+tm)log q) to O(mtlog q), and (3) the storage overhead of the self-healing key distribution with $t$-revocation capability at each group member from O(m2log q) to O(mlogq), where $t$ is the maximum number of colluding group members, $m$ is the number of sessions, and $q$ is a prime number that is large enough to accommodate a cryptographic key. All these results are achieved without sacrificing the unconditional security of key distribution. In addition, this paper presents two techniques that allow trade-off between the broadcast size and the recoverability of lost session keys. These two methods further reduce the broadcast message size in situations where there are frequent but short-term disruptions of communication and where there are long-term but infrequent disruptions of communication, respectively.
Research needs in aluminum structure∗ (2008)

Abstract The technology required for the design, fabrication, operation, and maintenance of aluminum structures for ships and craft is reviewed to assess the needs for improvements in that technology. The areas reviewed are material property and behavior, structural design, structural details, welding and fabrication, joining aluminum to steel, residual stresses and distortion, fatigue design and analysis, fire protection, vibration, maintenance and repair, mitigating slam loads, and emerging technologies.
Preputial Sebocyte 5 -Reductase Isoform Specificity (1997)

We determined whether the 5α-reductase (5α-R) isozyme specificity in rat preputial sebocytes is in accordance with that of sebaceous glands (type 1 isoform) or with that of other genital tract androgen-dependent organs (type 2). Immunostaining indicated expression of type 1 5α-R in preputial epithelial cells in the gland as well as in culture. Northern blots and ribonuclease protection assays both showed the presence of the type 1 isozyme in preputial sebocytes, with little if any expression of the type 2 messenger RNA. Ribonuclease protection assay demonstrated that both homogenized preputial gland and freshly dispersed preputial cells express 2-fold more 5α-R type 1 messenger RNA than does skin and 7-fold more than cultured preputial cells. Since cultured preputial cells do not fully differentiate in monolayer culture, these findings suggest that 5α-R is increasingly expressed as sebaceous cells differentiate. The predominance of the type 1 isoform in preputial sebocytes is important because it indicates programming by a skin- and sebocyte-specific signal in the midst of the genital tract where the type 2 isoform otherwise predominates.
Synthesis of Silver Nanoplates by Two-Dimensional Oriented Attachment (2012)

Synthesis of silver nanoplates was studied in the modified polyol method, where the nucleation and seed stage occurred in a poly(ethylene glycol) (PEG)-water mixture solution, and the growth stage happened in the PEG environment. The morphological evolution of nanoplates was characterized using UV, SEM, and TEM. Interestingly, plane nanostructures with unusual jagged edges were finally formed in our modified polyol method. Using TEM, we observed the medium state of fusion between two nanoplates, resulting in generating unusual jagged edges. Therefore, a novel two-dimensional oriented attachment occurred in our modified polyol method, which involves smaller nanoplates as the building blocks. Further control experiments showed that the presence of water could break this kinetic preferred reactivity, leading to the formation of nanoparticles.
Essential Role for<i>dlg</i>in Synaptic Clustering of Shaker K<sup>+</sup>Channels<i>In Vivo</i> (1997)

The assemblage of specific ion channels and receptors at synaptic sites is crucial for signaling between pre- and postsynaptic cells. However, the mechanisms by which proteins are targeted to and clustered at synapses are poorly understood. Here we show that the product of the Drosophila discs-large gene, DLG, is colocalized with Shaker K+ channels, which are clustered at glutamatergic synapses at the larval neuromuscular junction. In heterologous cells, DLG can cluster Shaker-type K+ channels, and, in the yeast two-hybrid system, the DLG PDZ1-2 domains bind directly to the C-terminal tail of Shaker proteins. We also demonstrate that DLG-Shaker interactions are required in vivo for Shaker clustering at the neuromuscular junction. Synaptic clustering of Shaker channels is abolished not only by mutations in dlg but also by a mutation in Shaker that deletes its C-terminal DLG binding motif. Analyses of various dlg mutant alleles suggest that channel clustering and synaptic targeting functions depend on distinct DLG domains. These studies demonstrate for the first time that DLG plays an important role in synaptic organization in vivo that correlates with its ability to bind directly to specific membrane proteins of the synapse.
Effects of some treatments on the storability of papaya fruits (2009)

In this paper,for studying the effects of treatments on the control of the postharvest diseases related to fruit quality and some enzyme activities of papaya fruit(cv.Risheng) the fruit were treated with hot water,ethylene absorbent and 1-MCP respectively.The results indicated that ethylene absorbent and 1-MCP significantly inhibited the occurrence of diseases,delayed fruit softening and increased the accumulation of sugars in papaya fruit,and maintained higher level of SOD and lower level of MDA.It indicated that application of ethylene absorbent and 1-MCP were beneficial to fruit quality and storage life.We suggest that ethylene absorbent and 1-MCP could be used for improving the storability of papaya fruit.
Computer-assisted frameless stereotaxy in transsphenoidal surgery at a single institution: review of 176 cases (2006)

Frameless stereotaxy is a safe and effective modality for the treatment of recurrent or invasive sellar masses. All three frameless stereotaxy modalities provided accurate information regarding the anatomical midline and the trajectory to the sella turcica. The MR imaging, CT scanning, and fluoroscopic stereotaxy modalities all have unique advantages as well as specific limitations.
Edge and motion controlled spatial upconversion (1994)

In this paper a new edge and motion adaptive normal definition to higher definition (NDHD) scanning rate conversion algorithm is presented. The algorithm utilizes both edge and motion information. Edge analysis is done separately inter- and intrafield, intended for interpolation in stationary and moving regions, respectively. Motion information is obtained from a frame difference signal which is expanded horizontally if horizontal interfield edge is detected. Steerable FIR-filters are used in the interpolation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A statistical approach to the design of an adaptive self-normalizing silence detector (1983)

Silence detection is an important aspect of automatic speech recognition. In this paper a silence detector is described which classifies each frame of an utterance as being silent or nonsilent. No attempt is made to determine the endpoints of words. The silence detector is based upon a statistical test and has the properties that it is adaptive, self-normalizing, speaker independent, and script independent. No training sets are required, although it is assumed that the first part of a signal is silent. An experiment is described in which the silence detector was successfully applied to more than 2 h of isolated-word speech using a frame length of 1 cs.