gebhart/patrepeval huggingface dataset:
Influence of 3d Ions on the Production Efficiency of Intrinsic Defects in CaF<sub>2</sub> (1980)

Abstract The influence of 3d impurities on the production efficiency of V K and F centers is studied in low‐temperature X‐irradiated fluorite crystals. The optical absorption spectra of pure CaF 2 and CaF 2 doped with Mn, Fe, Co or Ni are compared before and after 15 K X‐irradiation. An increase in the efficiency for V k ‐centers production accompanied by the formation of M + ions (M = Mn, Fe, Co, Ni) is observed at 15 K. A decrease of the F‐centers production efficiency is also detected.
Attitudinal Changes Resulting from Repetitive Training of Operating Room Personnel Using High-Fidelity Simulation at the Point of Care (2009)

We investigated the impact of repetitive training using high-fidelity simulation (HFS) at the point of care on the teamwork attitudes of operating room (OR) personnel. Members of the general surgical OR teams at an academic medical center participated in two half-day point-of-care HFS team training sessions. Module 1 targeted teamwork competencies; Module 2 included a preoperative briefing strategy. Modules were separated by 1 month. For each training, participants completed pre- and postsession questionnaires that included a 15-item self-efficacy tool targeting teamwork competencies using a 6-point Likert-type scale. Pre- and postsession mean scores were compared with a t test. Matched pre- and postsessions questionnaires were collected from 38 and 39 participants for Module 1 and Module 2, respectively. Mean item improvement from pre- to posttraining was 0.43 units (range, 0.23 to 0.69 units) for Module 1 and 0.42 units (range, 0.15 to 0.53 units) for Module 2. After Bonferroni adjustment, statistically significant improvement in scores from pre- to posttraining increased from four items after Module 1 to nine items after Module 2. Repetitive training of interdisciplinary OR teams through HFS at the point of care increases the effectiveness of promoting attitudinal change toward team-based competencies among participants.
An analysis of adequacy of dialysis in a selected population on CAPD for over 3 years: the influence of urea and creatinine kinetics. (1993)

Adequacy of dialysis is addressed to minimize the negative consequences of underdialysis. The results of the NCSD demonstrated that urea kinetic modelling (UKM) is a useful tool in the measurement of adequacy of dialysis: Kt/V values of 1 are considered adequate to prevent complications when daily protein intake is appropriate. For CAPD no similar prospective studies exist, and consequently there is no information comparable to that for haemodialysis. Preliminary data have communicated controversial results about the usefulness of UKM for CAPD prescription. On the other hand creatinine kinetics has been proposed as an alternative to UKM to define adequacy of dialysis on CAPD. However, these results should be considered preliminary because of the small size of the series and the short observation period. The objective of this paper is to study the role of these two kinetic models in defining adequacy of dialysis in a long-term, selected CAPD population. We have studied 56 patients treated for at least 3 years on CAPD (3-11 years; mean observation period 5 years; 3996 patient-months). Urea kinetic model (UKM) (urea weekly (W) Kt/V and NPCR) and creatinine kinetics (Efficacy number (EN) and K) were determined annually. According to the present data we can conclude that Kt/V is an appropriate tool for defining adequacy in patients on CAPD. Values of weekly Kt/V greater than 1.7-1.8, with NPCR more than 1 g/kg/day, assure an adequate clinical outcome. Conversely, values on the Kt/V scale less than 1.7 entail a greater rate of complications. Our data also confirm that maintaining a serum albumin > 536-551 mumol/l (3.7-3.8 g/dl) is related to lower morbidity and mortality, and should be a major objective for CAPD patients. Consequently a relationship between dose of dialysis in terms of urea mass balance and protein nutrition can be established. After 5 years on CAPD, when all residual renal function is generally lost, Kt/V values in excess of 1.9 are difficult to achieve. Based on currently available information, we do agree with the interest of performing a prospective study on adequacy of dialysis based on the urea kinetic model in CAPD, which definitely defines its role. On the other hand, creatinine kinetics did not show sufficient discriminative capacity in terms of adequacy of dialysis. EN and Kt of creatinine values in the lower range (4.5-6 and less than 45-50 1/week respectively) were not necessarily associated with a poorer clinical outcome.(ABSTRACT TRUNCATED AT 400 WORDS)
Review: Heat Shock Proteins and Systemic Lupus Erythematosus (1991)

This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published work on this subject falls into three main categories: the overexpression of hsps in SLE, the development of autoantibodies to hsps in SLE, and the surface expression of hsps in peripheral blood mononuclear cells in SLE. This work is reviewed in detail. In conclusion, we describe areas for further study and outline ways in which this is being approached.
Theoretical and experimental studies of surface plasmons excited at metal-uniaxial dielectric interface (2011)

In this letter, surface plasmons (SPs) excited at the metal-uniaxial dielectric interface are investigated both theoretically and experimentally. The dispersion relations of SPs are derived for the cases where the optical axis of uniaxial medium is parallel the interface or in the incident plane perpendicular to the interface. The theoretical predictions are verified by a Kretschmann–Raether [W. L. Barnes, A. Dereux, and T. W. Ebbesen, Nature (London) 424, 824 (2003)] configuration with azobenzene polymer as photoinduced uniaxial medium. The attenuated total reflection spectra clearly show that the dependence of the SPs propagation properties on the orientations of optical axis, which is consistent with the theoretical analysis. The results of this study provide a useful approach to modulate SPs through adjusting the azobenzene molecular orientation.
On the propagating radical of macromonomers (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the propagating radical of macromonomersYasuhisa Tsukahara, Kiyoharu Tsutsumi, Yuya Yamashita, and Shigetaka ShimadaCite this: Macromolecules 1989, 22, 6, 2869–2871Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/ma00196a063https://doi.org/10.1021/ma00196a063research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment (2020)

Abstract Though endometriosis and infertility are clearly associated, the pathophysiological mechanism remains unclear. Previous work has linked endometrial ARID1A loss to endometriosis-related endometrial non-receptivity. Here, we show in mice that ARID1A binds and regulates transcription of the Foxa2 gene required for endometrial gland function. Uterine specific deletion of Arid1a compromises gland development and diminishes Foxa2 and Lif expression. Deletion of Arid1a with Ltf-iCre in the adult mouse endometrial epithelium preserves gland development while still compromising gland function. Mice lacking endometrial epithelial Arid1a are severely sub-fertile due to defects in implantation, decidualization, and endometrial receptivity from disruption of the LIF-STAT3-EGR1 pathway. FOXA2 is also reduced in the endometrium of women with endometriosis in correlation with diminished ARID1A, and both ARID1A and FOXA2 are reduced in non-human primates induced with endometriosis. Our findings describe a role for ARID1A in the endometrial epithelium supporting early pregnancy establishment through the maintenance of gland function.
Optimization of the growth and marennine production by the diatom Haslea ostrearia in photobioreactor (2021)

The benthic diatom Haslea ostrearia which has the capacity to excrete a blue pigment called marennine remains a challenging organism to culture in a photobioreactor (PBR). This study investigates the interest of culture in conventional mixed PBR over immobilized-cell protocols which proved successful but have rather low extracellular marennine (EMn) due to a limitation in mass or light transfer in the biofilm. In contrary, culture in mixed PBR has been proven to overcome culture mass transfer limitation, and to provide a high level of control over light access to cells, enabling the application of systematic optimization of photosynthesis-related kinetics. Increasing the dissolved inorganic carbon concentration up to values of around 5–10 mM was found to increase both growth kinetics and EMn production. Growth medium enrichment with silica (Si) was however found to be challenging due to chemical precipitation. A fed-batch strategy on Si-P supply was implemented, leading to an increase in biomass productivity (51.8 ± 2.3 mgX L−1 d−1). Although EMn was produced continuously, the nutrient-limited conditions led to higher productivity with 9.2 ± 1.7 mgEMn m−2 d−1, 37.9 ± 0.7 mgEMn m−2 d−1 and 54.5 ± 1.8 mgEMn m−2 d−1 for phosphorus, silicon and nitrogen deprivation respectively. The effect of light availability was also investigated, as represented by the Mean Rate of Photon Absorption (MRPA). A direct relation was shown for both biomass and EMn production kinetics. However, maximal biomass and EMn productivities were found at different MRPA values, respectively 1.7 ± 0.1 gx m−2 d−1 at 12.3 μmolhν gx−1 s−1 and 11.0 ± 0.5 mgEMn m−2 d−1 at 8.4 μmolhν gx−1 s−1. Finally, a continuous EMn production was obtained in optimal conditions, leading to a productivity of 4.5 ± 0.16 mgEMn L−1 d−1, enabling validation of the conventional mixed PBR for H. ostrearia culture and continuous EMn production.
Physics Basis for High-Beta, Low-Aspect-Ratio Stellarator Experiments (1999)

High-beta, low-aspect-ratio (compact) stellarators are promising solutions to the problem of developing a magnetic plasma configuration for magnetic fusion power plants that can be sustained in steady-state without disrupting. These concepts combine features of stellarators and advanced tokamaks and have aspect ratios similar to those of tokamaks (2-4). They are based on computed plasma configurations that are shaped in three dimensions to provide desired stability and transport properties. Experiments are planned as part of a program to develop this concept. A beta = 4% quasi-axisymmetric plasma configuration has been evaluated for the National Compact Stellarator Experiment (NCSX). It has a substantial bootstrap current and is shaped to stabilize ballooning, external kink, vertical, and neoclassical tearing modes without feedback or close-fitting conductors. Quasi-omnigeneous plasma configurations stable to ballooning modes at beta = 4% have been evaluated for the Quasi-Omnigeneous Stellarator (QOS) experiment. These equilibria have relatively low bootstrap currents and are insensitive to changes in beta. Coil configurations have been calculated that reconstruct these plasma configurations, preserving their important physics properties. Theory- and experiment-based confinement analyses are used to evaluate the technical capabilities needed to reach target plasma conditions. The physics basis for these complementary experiments is described.
Isoflavanones from the allelopathicaqueousrootexudate of Desmodiumuncinatum (2003)

Three isoflavanones, 5,7,2′,4′-tetrahydroxy-6-(3-methylbut-2-enyl)isoflavanone (1), 4′′,5′′dihydro-5,2′,4′-trihydroxy-5′′-isopropenylfurano-(2′′,3′′;7,6)-isoflavanone (2) and 4′′,5′′-dihydro2′-methoxy-5,4′-dihydroxy-5′′-isopropenylfurano-(2′′,3′′;7,6)-isoflavanone (3) and a previously known isoflavone 5,7,4′-trihydroxyisoflavone [genistein (4)] were isolated and characterised spectroscopically from the rootexudate of the legume Desmodiumuncinatum (Jacq.) DC. We propose the names uncinanone A, B, and C for compounds 1, 2 and 3, respectively. Isolated fractions containing uncinanone B (2) induced germination of seeds from the parasitic weed Striga hermonthica (Del.) Benth. and fractions containing uncinanone C (3) moderately inhibited radical growth, the first example of a newly identified potential allelopathic mechanism to prevent S. hermonthica parasitism. Three isoflavanones, including the two shown were isolated and characterised spectroscopically from the rootexudate of the legume Desmodiumuncinatum (Jacq.) DC. Isolated fractions containing isoflavanone (R=H) induced germination of seeds from the parasitic weed Striga hermonthica (Del.) Benth and fractions containing the isoflavanone (R=Me) moderately inhibited radical growth, the first example of a newly identified potential allelopathic mechanism to prevent S. hermonthica parasitism.
Case-Based Reasoning for Insulin Bolus Advice (2016)

Results from the 6-week study indicate the potential benefit of including parameters exercise, alcohol and glucose-rate of change for insulin dosing decision support.
Evidence for a re-oxidizing enzyme in human pancreatic juice (1986)

Conference Article| October 01 1986 Evidence for a re-oxidizing enzyme in human pancreatic juice PATRICIA M. GUYAN; PATRICIA M. GUYAN *Department of Biochemistry, Medical School, Manchester, M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOHN BUTLER; JOHN BUTLER †Paterson Laboratories, Christie Hospital, Manchester, M20 9BX, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOAN M. BRAGANZA; JOAN M. BRAGANZA ‡Gastroenterology Unit, Royal infirmary, Manchester M13 9WL, U.K. Search for other works by this author on: This Site PubMed Google Scholar FRANK S. STEVEN FRANK S. STEVEN *Department of Biochemistry, Medical School, Manchester, M13 9PT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: March 21 1986 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1986 Biochemical Society1986 Biochem Soc Trans (1986) 14 (5): 890–891. https://doi.org/10.1042/bst0140890 Article history Received: March 21 1986 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation PATRICIA M. GUYAN, JOHN BUTLER, JOAN M. BRAGANZA, FRANK S. STEVEN; Evidence for a re-oxidizing enzyme in human pancreatic juice. Biochem Soc Trans 1 October 1986; 14 (5): 890–891. doi: https://doi.org/10.1042/bst0140890 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: SOD, superoxide dismutase This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
High-Gradient Millimeter-Wave Accelerator on a Planar Dielectric Substrate (2001)

We report the first high-gradient studies of a millimeter-wave accelerator, employing for the first time a planar dielectric accelerator, powered by means of a 0.5-A, 300-MeV, 11.424-GHz drive electron beam, synchronous at the 8th harmonic, 91.392 GHz. Embedded in a ring-resonator circuit within the electron beam line vacuum, this structure was operated at 20 MeV/m, with a circulating power of 200 kW, for 2 x 10(5) pulses, with no sign of breakdown, dielectric charging, or other deleterious high-gradient phenomena. We also present the first measurement of the quadrupolar content of an accelerating mode.
Deep whole-genome sequencing of 3 cancer cell lines on 2 sequencing platforms (2019)

To test the performance of a new sequencing platform, develop an updated somatic calling pipeline and establish a reference for future benchmarking experiments, we performed whole-genome sequencing of 3 common cancer cell lines (COLO-829, HCC-1143 and HCC-1187) along with their matched normal cell lines to great sequencing depths (up to 278x coverage) on both Illumina HiSeqX and NovaSeq sequencing instruments. Somatic calling was generally consistent between the two platforms despite minor differences at the read level. We designed and implemented a novel pipeline for the analysis of tumor-normal samples, using multiple variant callers. We show that coupled with a high-confidence filtering strategy, the use of combination of tools improves the accuracy of somatic variant calling. We also demonstrate the utility of the dataset by creating an artificial purity ladder to evaluate the somatic pipeline and benchmark methods for estimating purity and ploidy from tumor-normal pairs. The data and results of the pipeline are made accessible to the cancer genomics community.
Functional mapping of Autographa california nuclear polyhedrosis virus genes required for late gene expression (1988)

A plasmid containing the bacterial chloramphenicol acetyltransferase (CAT) gene under the control of an Autographa california nuclear polyhedrosis virus (AcNPV) late gene promoter was constructed. This plasmid (pL2cat) also contained the AcNPV hr5 enhancer element. Transient-expression assay experiments indicated that the late promoter was active in Spodoptera frugiperda cells cotransfected with pL2cat and AcNPV DNA but not when pL2cat was transfected alone. Low levels of CAT activity were observed in cells cotransfected with pL2cat and pIE-1 DNAs. However, CAT activity was not induced in a similar plasmid which lacked the cis-linked enhancer element, indicating that the enhancer was required for expression of the late gene. Cotransfection mapping of pPstI clones of AcNPV DNA indicated that the pPstI-G clone of viral DNA contained a factor which further stimulated late gene expression 3- to 10-fold. Transient-expression assay analysis of subclones of pPstI-G localized the trans-active factor to a 3.0-kilobase XbaI fragment. The nucleotide sequence of this fragment was determined and found to contain three potential open reading frames. A computer-assisted search of a protein database revealed no closely related proteins. One of the predicted amino acid sequences contained potential metal-binding domains similar to those found in nucleic acid-binding proteins. Subcloning and subsequent CAT assay indicated that two of the open reading frames were required for the activation of pL2cat. Nuclease S1 mapping of infected and transfected RNAs indicated that the two open reading frames were transcribed as delayed-early genes. Quantitative nuclease S1 analysis and differential DNA digestion of recovered plasmids indicated that the activation of pL2cat was not due to an increase in steady-state levels of mRNA replication of the viral DNA.
Role of novel protein kinase C isoforms in Lyme arthritis (2007)

Inflammation caused by Borrelia burgdorferi infection occurs as a result of induction of pro-inflammatory cytokines from activation of multiple signalling pathways. It has previously been shown that mitogen-activated protein kinase (MAPK) and Janus kinase/signal transducer and activator of transcription signalling pathways are activated by B. burgdorferi in cultured human chondrocytes. Protein kinase C (PKC) signalling pathways are potential candidates that may control these downstream signalling pathways. Here we show that B. burgdorferi infection leads to phosphorylation and activation of novel PKC isoforms (PKC delta, epsilon, eta and theta) in a time-dependent manner. A specific inhibitor of novel PKC isoforms blocked the induction of pro-inflammatory molecules in response to B. burgdorferi infection as did transient transfection of novel PKC dominant-negative plasmids into chondrocytes. B. burgdorferi-induced p38 MAPK phosphorylation was also significantly inhibited by an inhibitor of novel PKC isoforms, suggesting that PKC activation occurs upstream of p38 activation. In vivo, administration of an inhibitor of classical and novel PKC isoforms to C3H/HeN mice infected with B. burgdorferi resulted in significantly reduced ankle inflammation and swelling. In conclusion, these data suggest that novel PKC isoforms are specifically activated by B. burgdorferi infection and this can contribute to the regulation of inflammation in vitro and in vivo.
A NEW TOTAL SYNTHESIS OF ESTRONE (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA NEW TOTAL SYNTHESIS OF ESTRONEWilliam S. Johnson and Robert G. ChristiansenCite this: J. Am. Chem. Soc. 1951, 73, 11, 5511–5512Publication Date (Print):November 1, 1951Publication History Published online1 May 2002Published inissue 1 November 1951https://pubs.acs.org/doi/10.1021/ja01155a576https://doi.org/10.1021/ja01155a576research-articleACS PublicationsRequest reuse permissionsArticle Views311Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neural network modeling of fabrication yield using manufacturing data (2011)

This paper describes the creation of artificial neural network models using production line data and illustrates their usefulness for process control in semiconductor manufacturing. Three artificial neural network models are created. The first models a high aspect ratio etch process. The other two are created to predict yield metrics from inline critical dimension (CD) measurements. One model predicts the number of faults on a die, and the other predicts the probability of die failure at probe. The high aspect ratio etch model has an average prediction error of 3.9%. The average prediction error for the number of faults on a die is 14.9%, and the average prediction error for probability of die failure at probe is 21.8%. A sensitivity analysis is performed on each model to illustrate how they can be used to judge the relative impact of each input.