gebhart/patrepeval huggingface dataset:
Biokinetics and Biodynamics of Nanomaterial Interactions (2009)

Abstract : A requirement to assess toxicity of nanomaterials is to assess their interactions with available viability assays. Single-walled carbon nanotubes (SWCNT), fullerenes (C60), carbon black (CB), nC60, and quantum dots (QD) were studied in vitro to determine their toxicity in a number of cell types. The classical dye-based assays such as MTT and neutral red (NR) that determine cell viability produced invalid results with some NM (nanomaterials) due to NM/dye interactions and/or NM adsorption of the dye/dye products. In this study, human epidermal keratinocytes (HEK) were exposed in vitro to CB, SWCNT, C60, nC60, and QD to assess viability with calcein AM (CAM), Live/Dead (LD), NR, MTT, Celltiter 96 AQueous One (96 AQ), alamar Blue (aB), Celltiter-Blue (CTB), CytoTox OneTM (CTO), and flow cytometry. In addition, trypan blue (TB) was quantitated by light microscopy. Assay linearity (R2 value) was determined with HEK plated at concentrations from 0 to 25,000 cells per well in 96-well plates. HEK were treated with serial dilutions of each NM for 24 h and assessed with each of the viability assays. TB, CAM and LD assays, which depend on direct staining of living and/or dead cells, were difficult to interpret due to physical interference of the NM with cells. Results of the dye-based assays varied a great deal, depending on the interactions of the dye/dye product with the carbon nanomaterials (CNM). The optimal assay for use with carbon and noncarbon NM was 96 AQ. Unlike small molecules, CNM interact with assay markers to cause variable results with classical toxicology assays and may not be suitable for assessing nanoparticle cytotoxicity. Therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment.
Dehydroquinate synthase: the role of divalent metal cations and of nicotinamide adenine dinucleotide in catalysis (1989)

The cofactor requirements of dehydroquinate synthase from Escherichia coli have been characterized. The homogeneous enzyme, purified from the overproducing strain RB791 (pJB14), is a monomeric metalloenzyme of Mr = 39,000 that contains 1 mol of tightly bound Co(II) according to atomic absorption analysis. The holoenzyme rapidly loses activity upon incubation with EDTA, giving rise to a stable but catalytically inactive apoenzyme. Activity is fully restored by reconstitution with Co(II) and partially restored with other divalent cations. Reconstitution of the apoenzyme with Zn(II) (which is probably the functioning metal in vivo) restores activity to 53% of the level observed with the Co(II)-holoenzyme. The presence of the substrate 3-deoxy-D-arabino-heptulosonate 7-phosphate (1) blocks the inactivation by EDTA. Dehydroquinate synthase also binds 1 mol of NAD+, the presence of which is essential for catalytic activity. The rate constant for the dissociation of NAD+ from the Co(II)-holoenzyme was found to be 0.024 min-1. Under turnover conditions with saturating levels of substrate, the dissociation rate of NAD+ increases by a factor of 40, to 1 min-1. Under these conditions (pH 7.5, 20 degrees C), the Km for NAD+ was determined to be 80 nM.
Electroquasistatic induction micromotors (2003)

The steady-state operation of the electroquasistatic induction micromotor (IM) is investigated. A rotary pancake IM compatible with surface micromachining serves as an example. A model is developed to predict the electric potential, field, and free charge within the IM. The model also predicts the motive torque and transverse force of electric origin acting on its rotor. The torque is balanced against bushing friction and windage to determine rotor velocity; the bushing friction is modeled as a function of the transverse force acting on the rotor. The model is used to study IM performance and its dependence on IM dimensions and material properties. For example, IM performance is predicted to be a complex function of axial IM dimensions and a strong function of rotor conductivity. The study also reveals that IM performance can differ significantly from that of the variable-capacitance micromotor. For example, the dependence of motive torque and transverse force on velocity and the excitation and control requirements can all be significantly different.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lack of concordance between heat shock proteins and the development of tolerance to teratogen‐induced neural tube defects (1993)

The present study was undertaken to examine the role of heat shock response in the development of tolerance and cross-tolerance in an in vivo murine model of teratogen-induced neural tube defects. The experimental paradigm designed to address this question was to utilize inbred mouse strains that differed in their sensitivity to hyperthermia and valproic acid induced neural tube defects, subjecting the dams to subteratogenic pretreatments with either heat or valproic acid at two different timepoints during development prior to the administration of the teratogenic insult. A statistically significant reduction in the frequency of neural tube defects and/or embryolethality following a pretreatment in dams subsequently exposed to a teratogenic treatment was considered evidence for the induction of tolerance. This was observed in the SWV embryos exposed to the 38 degrees C pretreatment at 8:06 and to embryos exposed to either pretreatment temperature at 8:10 prior to a teratogenic heat shock at 8:12. In the LM/Bc embryos, only the 41 degrees C pretreatment at 8:06 induced thermotolerance. There was no evidence of tolerance induced in either mouse strain using valproic acid. On the other hand, cross-tolerance was clearly demonstrated in this study, with a low temperature (41 degrees C) pretreatment successfully protecting SWV fetuses from a subsequent teratogenic treatment with valproic acid, while valproic acid (200 mg/kg) was effective in reducing the risk of hyperthermia-induced neural tube defects in the LM/Bc fetuses. In all instances, tolerance was induced in the absence of significant induction of hsp synthesis. The lack of concordance between hsps and thermotolerance suggests that some other factor(s) is involved in conferring thermotolerance on developing murine embryos.
Involvement of integrins α<sub>3</sub>β<sub>1</sub> and α<sub>5</sub>β<sub>1</sub> and glycoprotein IIb in megakaryocyte‐induced osteoblast proliferation (2010)

As the prevalence of osteoporosis is expected to increase over the next few decades, the development of novel therapeutic strategies to combat this disorder becomes clinically imperative. These efforts draw extensively from an expanding body of knowledge pertaining to the physiologic mechanisms of skeletal homeostasis. To this body of knowledge, we contribute that cells of hematopoietic lineage may play a crucial role in balancing osteoblastic bone formation against osteoclastic resorption. Specifically, our laboratory has previously demonstrated that megakaryocytes (MKs) can induce osteoblast (OB) proliferation in vitro, but do so only when direct cell-to-cell contact is permitted. To further investigate the nature of this interaction, we have effectively neutralized several adhesion molecules known to function in the analogous interaction of MKs with another cell type of mesenchymal origin-the fibroblast (FB). Our findings implicate the involvement of fibronectin/RGD-binding integrins including alpha3beta1 (VLA-3) and alpha5beta1 (VLA-5) as well as glycoprotein (gp) IIb (CD41), all of which are known to be expressed on MK membranes. Furthermore, we demonstrate that interleukin (IL)-3 can enhance MK-induced OB activation in vitro, as demonstrated in the MK-FB model system. Taken together, these results suggest that although their physiologic and clinical implications are very different, these two models of hematopoietic-mesenchymal cell activation are mechanistically analogous in several ways.
Pyrrole aus Etacrynsäure (1992)

Abstract Die 1,4‐Dicarbonyl‐ und 1,4,7‐Tricarbonyl‐Verbindungen 1 cyclisieren mit Ammoniak oder Methylamin zu den Pyrrolen 2 . Das 1,4‐Diketon 1b reagiert mit Hydrazin in Ethanol abhängig von der Temp, zum Pyridazin 3 oder zum N ‐Amino‐pyrrol 4 , das sich zum stabilen Amid 5 acetylieren läßt. Bei der Umsetzung von 1b mit Hydroxylamin wird das N ‐Hydroxy‐pyrrol 6 erhalten.
Iterative Image Dehazing Using the Dark Channel Prior (2016)

The dark channel prior (DCP)-based image dehazing method has been widely used for enhancing visibility of outdoor images. However, since the DCP-based method assumes that the minimum values within local patches of natural outdoor haze-free images are zero, underestimation of the transmission is inevitable when the assumption does not hold. In this letter, a novel iterative image dehazing algorithm is proposed to compensate for the underestimated transmission. Experimental results show that the proposed method can improve the dehazing performance by increasing the transmission estimation accuracy.
Predicting conditional branch directions from previous runs of a program (1992)

Article Free Access Share on Predicting conditional branch directions from previous runs of a program Authors: Joseph A. Fisher View Profile , Stefan M. Freudenberger View Profile Authors Info & Claims ASPLOS V: Proceedings of the fifth international conference on Architectural support for programming languages and operating systemsSeptember 1992 Pages 85–95https://doi.org/10.1145/143365.143493Online:01 September 1992Publication History 182citation1,070DownloadsMetricsTotal Citations182Total Downloads1,070Last 12 Months45Last 6 weeks12 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
International Workshop on Improving Data Quality and Quantity for XAFS Experiments (Q2XAFS 2011) (2012)

An introductory overview to the special issue papers from the Q2XAFS Workshop in this issue of the journal.
Phase behavior of nylon 6/trifluoroethanol/carbon dioxide mixtures (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhase behavior of nylon 6/trifluoroethanol/carbon dioxide mixturesS. J. Suresh, R. M. Enick, and E. J. BeckmanCite this: Macromolecules 1994, 27, 2, 348–356Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ma00080a006https://doi.org/10.1021/ma00080a006research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer (2010)

This study is the first, to our knowledge, to establish a relationship between the radiation dose received by the heart during radiotherapy for a childhood cancer and long-term cardiac mortality. This study also confirms a significant excess risk of cardiac mortality associated with a high cumulative dose of anthracyclines.
Saturn power generation with electrodynamic tethers in polar orbit (2009)

A power generation scheme based on bare electrodynamic tethers (EDT), working in passive mode is investigated for the purpose of supplying power to scientific missions at Saturn. The system employs a spinning EDT on a lowaltitude\npolar orbit which permits to efficiently convert plasmasphere energy into useful power. After optimizing the tether design for power generation we compute the supplied power along the orbit and the impact of the Lorentz force\non the orbital elements as function of the tether and orbit characteristics.\nAlthough uncertainties in the current ionosphere density modeling strongly affect the performance of the system the peak power density of the EDT appears be greater than conventional power systems.
An Investigation into Thumb Rotation Using High Density Surface Electromyography of Extrinsic Hand Muscles (2013)

Improving our understanding of mechanisms driving thumb rotation could potentially advance the design of current upper limb prosthesis to incorporate powered thumb control increasing the dexterity of the device. This study investigates thumb rotation using high density surface electromyography (HD-sEMG) of extrinsic hand muscles. An apparatus was designed and developed to test thumb rotation. Relevant data were acquired during isometric voluntary contractions with a 20-40% of maximum voluntary contraction (MVC) performed by 7 healthy right-handed volunteers. Data were processed and analyzed. Analysis showed that, thumb position could be extracted using features extracted from the HD-sEMG data recorded with high statistical significance.
Angiotensin II-Induced [3H]Adenosine Release from in situ Rat Lung (1990)

The purpose of the present study was to determine whether Ang II releases adenosine from the perfused rat lung. Rat lungs were perfused in situ with a physiological salt solution and were loaded with [3H]adenosine. The release of 3H from the perfused rat lung in response to intra-arterial injections of Ang II and other hormones was quantitated. Studies were conducted in both normal rats and in rats that had been nephrectomized before surgery to avoid exposure of the lungs to high levels of endogenous Ang II. Bolus doses of Ang II (10(-12)-10(-7) mol) increased the efflux of 3H from the lungs. Analysis of this effluent by thin-layer chromatography indicated that most of the Ang II-induced release of 3H was [3H]adenosine. The maximal response was usually obtained with 10(-9) mol, and higher doses (10(-8) and 10(-7) mol) mobilized less [3H]adenosine, which suggested tachyphylaxis. The effect of exogenous Ang II on [3H]adenosine release was greatly enhanced when activation of the endogenous renin-angiotensin system was prevented with prior nephrectomy. Infusion of the Ang II selective antagonist, (1-Sar-8-Ile)-Ang II, blocked Ang II-induced [3H]adenosine release. Neither norepinephrine, bradykinin, nor vasopressin consistently released adenosine. We conclude that (a) Ang II can induce the release of adenosine from the perfused rat lung, (b) this effect is receptor mediated, (c) this response is somewhat selective for Ang II, and (d) exposure to high levels of exogenous or endogenous Ang II causes tachyphylaxis so that Ang II-induced adenosine release is attenuated.
Paragonimus paishuihoensis Metacercariae in Freshwater Crabs, Potamon lipkei, in Vientiane Province, Lao PDR (2013)

Among Paragonimus species, P. paishuihoensis is one of the most mysterious and poorly understood species. Metacercariae are characterized by having a unique dendritically branched excretory bladder. However, the morphology of the adult worm remains unknown. To date, metacercariae of this species have been reported only in China and Thailand. In this study, we first found P. paishuihoensis metacercariae in freshwater crabs, Potamon lipkei, in Hinheub District, Vientiane, Lao PDR, with a prevalence of 77.7% and the average intensity of 10.3 (range 1-28) metacercariae per crab. The molecular data based on ITS2 and CO1 markers indicated that P. paishuihoensis from Laos and Thailand were almost completely identical and were close to members of the Paragonimus bangkokensis/Paragonimus harinasutai complex. Attempts to infect experimental animals (cats, dogs, and rats) with P. paishuihoensis were unsuccessful, suggesting that these animals might be unsuitable definitive hosts for the species. Further studies are necessary to elucidate the taxonomic status and life cycle of P. paishuihoensis.
Diet and Activity Altered Firmicutes at the Family Level. (2015)

<p>Family level changes within the Firmicutes phyla were identified from sequencing the 16S rRNA gene from samples at week 12 of the diet and activity protocol. A. Three members of the Clostridia class were altered by the diet and activity protocol: <i>Clostridiaceae</i>, <i>Lachnospiraceae</i>, and <i>Ruminococcaceae</i>. B. Two members of the Bacilli class were altered by the diet and activity protocol: <i>Lactobacillaceae</i> and <i>Turicibacteraceae</i>. C. One family was altered within the <i>Erysipelotrichi</i> class by diet and activity: <i>Erysipelotrichaceae</i>. Data were analyzed by 2-way ANOVA with a Sidak post hoc test. Significant differences indicated as follows: “*” p<0.05 for diet effect, “†” p<0.05 activity effect and “‡” p<0.05 diet and activity interaction. n = 6 mice/group.</p>
Dilated Superior Ophthalmic Vein: Clinical and Radiographic Features of 113 Cases (2017)

Dilated SOV is a rare radiographic finding resulting from a wide spectrum of etiologies with clinical implications ranging from benign to sight- and life-threatening. Dilated SOV is most often found with dural-cavernous fistula or carotid-cavernous fistula, orbital or facial arteriovenous malformation, and venous thrombosis. Recognition of this finding and management of the underlying condition is critical.
Supravalvular Aortic Stenosis: Clinical Experiences with Ten Patients Including Occurrences in Two Families. (1963)

s1 April 1963Supravalvular Aortic Stenosis: Clinical Experiences with Ten Patients Including Occurrences in Two Families.C. F. Wooley, M.D., C. V. Meckstroth, M.D., H. Sirak, M.D., D. M. Hosier, M.D., W. Molnar, M.D.C. F. Wooley, M.D.Search for more papers by this author, C. V. Meckstroth, M.D.Search for more papers by this author, H. Sirak, M.D.Search for more papers by this author, D. M. Hosier, M.D.Search for more papers by this author, W. Molnar, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-714_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical recognition of supravalvular aortic stenosis causing left ventricular outflow obstruction is a recent event. Initially considered to be a pathologic curiosity, it is now apparent that supravalvular aortic stenosis is relatively common in patients with obstruction to left ventricular outflow.Clinical experiences with 10 patients during a 2-year interval are presented. There were 7 males and 3 females, the youngest being 3½ years and the oldest 49 years. Two instances of familial occurrence include a mother and son in one family and a brother and sister in another.Clinical findings included an aortic systolic ejection murmur, absence of an... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 714-714KeywordsStenosisSystolic ejection murmur Issue Published: 1 April 1963 PDF DownloadLoading ...
A low cost wireless high bandwidth transmitter for sensor-integrated metal cutting tools and process monitoring (2009)

A transmitter system has been developed to collect high bandwidth data from sensor integrated cutting tools. The system collects high resolution end milling data during cutting without interfering with the machining process. A Bluetooth transmitter and instrumentation amplifiers are integrated into an end milling tool holder. The system is designed to power and sample a variety of sensors residing inside the tooling. The compliance of the tooling is unaffected by the sensing system. A tool integrated with a torque sensor is demonstrated. The cutting torque signal is compared to theory and experimental tests with a traditional bed type dynamometer.
Amphibian Skin Secretomics:  Application of Parallel Quadrupole Time-of-Flight Mass Spectrometry and Peptide Precursor cDNA Cloning to Rapidly Characterize the Skin Secretory Peptidome of<i>Phyllomedusa hypochondrialis</i><i>azurea:</i>Discovery of a Novel Peptide Family, the Hyposins (2007)

This study reports the variety of peptides present in the skin secretory peptidome of Phyllomedusa hypochondrialis azurea. Peptide structures, along with post-translational modifications, were elucidated by QTOF MS/MS analysis, cDNA sequencing, or a combination of both. Twenty-two peptides, including 19 novel structures, were identified from six different structural classes, including tryptophyllins, dermorphins, and a novel group of peptides termed hyposins. The study demonstrates the power of this combined approach to mine the rich peptidome compliment of the amphibian defensive skin secretome.
Association of HLA alleles with autism (2018)

Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis.
Neutralization of Smac/Diablo by Inhibitors of Apoptosis (IAPs) (2004)

Numerous members of the IAP family can suppress apoptotic cell death in physiological settings. Whereas certain IAPs directly inhibit caspases, the chief proteolytic effectors of apoptosis, the protective effects of other IAPs do not correlate well with their caspase inhibitory activities, suggesting the involvement of alternative cytoprotective abilities. To examine this issue, we have characterized the protective effects of an ancestral, baculoviral IAP (Op-IAP) in mammalian cells. We show that although Op-IAP potently inhibited Bax-mediated apoptosis in human cells, Op-IAP failed to directly inhibit mammalian caspases. However, Op-IAP efficiently bound the IAP antagonist Smac/Diablo, thereby preventing Smac/Diablo-mediated inhibition of cellular IAPs. Whereas reduction of Smac/Diablo protein levels in the absence of Op-IAP prevented Bax-mediated apoptosis, overexpression of Smac/Diablo neutralized Op-IAP-mediated protection, and an Op-IAP variant unable to bind Smac/Diablo failed to prevent apoptosis. Finally, Op-IAP catalyzed the ubiquitination of Smac/Diablo, an activity that contributed to Op-IAP-mediated inhibition of apoptosis. These data show that cytoprotective IAPs can inhibit apoptosis through the neutralization of IAP antagonists, rather than by directly inhibiting caspases.
Bacterial and fungal flora of dust deposits in a pig building. (1996)

The pig is not only a source but also a disperser of airborne bacteria in pig buildings. Speciation of the microbial flora in dust from the pig building suggests that many of the microorganisms were either of human or environmental origin. Nevertheless as some of these microorganisms are known opportunistic pathogens or allergens and because of the documented increased incidence of chronic respiratory symptoms in pig workers, precautions to reduce inhalation of microbial or dust particles by pig workers seem prudent.