gebhart/patrepeval huggingface dataset:
CLINICAL—LIVER, PANCREAS, AND BILIARY TRACT Acute Hemodynamic Response to -Blockers and Prediction of Long-term Outcome in Primary Prophylaxis of Variceal Bleeding (2009)

BACKGROUND & AIMS: Studies of variceal bleeding have shown that a hemodynamic response to treatment of portal hypertension is appropriate when the hepatic venous pressure gradient (HVPG) decreases below 12 mmHg or by 20% from baseline. However, in primary prophylaxis, many nonresponders do not bleed and 2 invasive procedures are needed to assess response. We investigated the long-term prognostic value of an acute response to -blockers and whether the target reduction in HVPG can be improved in primary prophylaxis. METHODS: An initial hemodynamic study was performed in patients with large varices and without previous bleeding. After baseline measurements were made, propranolol was administered intravenously and measurements were repeated 20 minutes later. Patients were given nadolol daily and a second hemodynamic study was performed. RESULTS: Of 105 patients, 15% had variceal bleeding. Using receiver operating characteristic curve analysis, a decrease of HVPG 10% was the best value to predict bleeding. In the initial study, 75 patients (71%) were responders (HVPG decreased to 12 mmHg or by 10%) and had a lower probability of first bleeding than nonresponders (4% vs 46% at 24 months; P .001). Acute responders also had a lower risk of developing ascites (P .001). Chronic responders had a lower probability of bleeding than nonresponders (P .001). There was a correlation between acute and chronic changes in HVPG (r 0.62; P .01). CONCLUSION: The acute hemodynamic response to -blockers can be used to predict the long-term risk of first bleeding. An HVPG reduction >10% from baseline is the best target to define response in primary prophylaxis. To view this article’s video abstract, go to the AGA’s YouTube Channel.
Sitagliptin Suppresses Active Ghrelin in Patients with Diabetes (2011)

Ghrelin is an appetite-stimulating hormone mainly produced by the stomach. Circulating levels of ghrelin increase in fasting sates and fall following meal. Sitagliptin is an orally available new class of anti-diabetic drug that inhibits dipeptidyl peptidase-4 (DPP-4) leading to 2-3 fold increase in the serum concentration of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This study was performed to determine the effects of sitagliptin on circulating levels of ghrelin in control subjects (N=15) and diabetic patients (N=46). The diabetic patients were treated with sitagliptin (N=15), metformin (N=16) or combination of sitagliptin and metformin (N=15) for one week. Serum concentrations of total and active ghrelin were determined immediately before and 2 hours after meal challenge.
Musashi Proteins in Neural Stem/Progenitor Cells (2012)

Many RNA-binding proteins are encoded in the genomes of various organisms and play a critical role in several life systems. The human genome contains thousands of RNA-binding proteins The most important biological role for these proteins involves the post-transcriptional eve n t s i n g e n e e x p r e s s i o n , e.g., splicing, export, stabilization, localization, and translation. Recent studies have shown that these post-transcriptional events are of similar importance to transcriptional and post-translational events and are highly orchestrated
Differences in Denaturation of Genetic Variants of Soy Glycinin (2002)

In heat denaturation studies conducted in the past the genetic variants of glycinin have been considered as a homogeneous group of proteins. In this work the validity of this assumption was tested. It was found by calorimetric studies that glycinin denatures heterogeneously at pH 7.6. When the temperature of isothermal treatment is increased from 70 to 82 degrees C the proportion of glycinin remaining native progressively decreases from 95% to 5% while the denaturation temperature of the glycinin remaining native increases from 88.5 to 95 degrees C. Similar trends were found for pH 3.8. Fractionation and subsequent analysis (MALDI-TOF and CE) of isothermally treated samples demonstrated that at pH 7.6 the heterogeneous denaturation is caused by differences in thermal stability of the genetic variants of glycinin. The stability increases in the order G2/G3/G1< A(4)< G5 < G4.
Synthesis of Na-4-mica from metakaolinite and MgO: characterization and Sr2+ uptake kinetics (1998)

Na-4-mica, a high-charge-density sodium fluorophlogopite mica of ideal chemical composition Na4Mg6Al4Si4O20F4xH2O has been prepared from a mixture of NaF, MgO and metakaolinite (the latter serving as an inexpensive aluminosilicate source). Highly crystalline Na-4-mica can be easily and economically synthesized from the above precursors in the temperature range 850–890 °C. 27Al and 29Si MAS NMR spectroscopy revealed that the Na-4-mica synthesized from metakaolinite is more close to the ideal nearest neighbor distribution of Al and Si compared to that prepared from magnesium aluminosilicate gel. Selective Sr exchange kinetic studies showed that the uptake was slow because of the somewhat large particle size as determined by scanning electron microscopy as well as restricted interlayer spacing.
Deformation-induced γ→DI-α_2 phase transformation of TiAl alloys (2007)

This paper has studied the deformation-induced γ→DI-α_2 phase transformation of TiAl alloys using high-resolution electron microscopy.Studies revealed that the deformation-induced γ→DI-α_2 phase transformation could occur in the regions where a deformation twin was blocked during both high-temperature and room-temperature deformations.Though the deformation conditions were completely different,these phase transformations have not exhibited any difference. High-resolution image observations of the deformation-induced DI-α_2 phase suggested that the orientation relationship between the DI-α_2 and γ phases remained the typical one:(0001)_(DI-α_2)//{111}_γ,[11(2)0]_(DI-α_2)//(110_γ.) The conversion of stacking sequence from ordered FCT to ordered non-equilibrium HCP structure was accomplished by the movement of a/611(2)] Shockley partial dislocations on every other {111}_γ plane.Compositional analysis based on X-ray energy dispersive spectroscopy(EDS) revealed that the DI-α_2 phase had the same composition as the matrix γ phase and no compositional diffusion occurred.The strong stress concentration in the intersection region was the major force to induce the γ→DI-α_2 phase transformation.
Microstructure Evolution Modeling during and after Deformation in 304 Austenitic Stainless Steel through Cellular Automaton Approach (2009)

A 2D cellular automaton approach was used to simulate microstructure evolution during and after hot deformation. Initial properties of the microstructure and dislocation density were used as input data to the cellular automaton model. The flow curve and final grain size were the output data for the dynamic recrystallization simulation, and softening kinetics curves were the output data of static and metadynamic recrystallization simulations. The model proposed in this work considered the effect of thermomechanical parameters (e.g., temperature and strain rate) on the nucleation and growth kinetics during dynamic recrystallization. The dynamic recrystallized microstructures at different strains, temperatures, and strain rates were used as input data for static and metadynamic recrystallization simulations. It was shown that the cellular automaton approach can model the final microstructure and flow curve successfully in dynamic recrystallization conditions. The postdeformation simulation results showed that the time for 50% recrystallization decreases with increasing strain for a given initial grain size and that dynamic recrystallization slows the postdeformation recrystallization kinetics compared to a model without dynamic recrystallization.
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors (2019)

Sterol 14α-demethylases (CYP51) are the cytochrome P450 enzymes required for biosynthesis of sterols in eukaryotes, the major targets for antifungal agents and prospective targets for treatment of protozoan infections. Human CYP51 could be and, for a while, was considered as a potential target for cholesterol-lowering drugs (the role that is now played by statins, which are also in clinical trials for cancer) but revealed high intrinsic resistance to inhibition. While microbial CYP51 enzymes are often inhibited stoichiometrically and functionally irreversibly, no strong inhibitors have been identified for human CYP51. In this study, we used comparative structure/functional analysis of CYP51 orthologs from different biological kingdoms and employed site-directed mutagenesis to elucidate the molecular basis for the resistance of the human enzyme to inhibition and also designed, synthesized, and characterized new compounds. Two of them inhibit human CYP51 functionally irreversibly with their potency approaching the potencies of azole drugs currently used to inhibit microbial CYP51.
Distant interactions between dimorphisms in HLA-DR4 radically affect recognition of defined peptides by a specific T cell clone (1999)

Several isolated dimorphisms recur in many HLA class II alleles, but it is not clear whether they merely influence the binding of peptides locally or have more general effects on their recognition by T cells. For example, interchanges in HLA-DRbeta include 86Gly <--> Val and 57Asp <--> Ser at either end of its alpha helix, and 71Arg <--> Lys in the middle. In DR4, the existence of six subtypes differing by single substitutions at these sites enabled us to assess their functional effects--both in isolation and in their natural context--on peptide presentation to a specific T cell clone with unusually broad cross-restrictions. Unexpectedly, the restriction imposed by 86Val was much more severe in the context of 71Arg than 71Lys, but was also more readily overcome by reducing the bulk of the 'p1' peptide 'anchor' residue (149Trp --> Phe). Moreover, when there was also a distant 57Asp-->Ser substitution, compensating similarly for 86Val proved much more difficult. Thus 86Val and 57Ser in combination had far more drastic effects on peptide presentation than they did separately, when peptide binding was also largely unchanged. These and other interactions with position 71 together provide strong evidence that the configuration of the peptide-DR4 complex is critical for T cell recognition, which could be affected by subtle conformational influences on the p1-9 core of the peptide or on the alpha helix of DR4beta (between positions 86 and 57). Ideally, therefore, the effects of individual class II substitutions should be considered in their natural context rather than in isolation.
A Possible Role of Prostacyclin to Stimulate Prolactin and Growth Hormone Release by Hypothalamic and Pituitary Actions, Respectively* (1984)

Prostacyclin (PGI2) (1-5 micrograms in 3 microliters 0.05 M Tris/HCl buffer, pH 7.5) and its stable metabolite, 6-oxo-PGF1 alpha, were microinjected into the third ventricle of ovariectomized rats, and plasma FSH, GH, PRL, and TSH levels were measured by RIA. Control animals received 3 microliters buffer. Injection of 5 micrograms PGI2 dramatically elevated plasma PRL values (4- to 5-fold) at 5 and 15 min, whereas the same dose of 6-oxo-PGF1 alpha produced a significant but smaller (2-fold) stimulatory effect. A delayed increase (1.5-fold) in plasma GH occurred after intraventricular PGI2 at 30 and 60 min. 6-Oxo-PGF1 alpha failed to alter GH levels. There were no alterations in plasma FSH and TSH after intraventricular injection of PGI2. Dispersed, overnight cultured cells from anterior pituitaries of ovariectomized rats were tested with 10(-4)-10(-7) M PGI2 and its metabolite. After 15 min of incubation, 3 X 10(-5) PGI2 produced a highly significant elevation in GH release (P less than 0.001), whereas there was no alteration in PRL levels. Only pharmacological doses of 6-oxo-PGF1 alpha (10(-4) M) stimulated GH release. There was no alteration in PRL release by the cultured cells even in the presence of 10(-4) PGI2. These results suggest that PGI2 stimulates PRL release by a hypothalamic action either to increase the release of PRL-releasing factor, or to decrease release of PRL-inhibiting factor, or by both mechanisms. The delayed stimulatory effect of PGI2 on the release of GH may be exerted via an effect on the anterior lobe itself, since PGI2 was effective in stimulating GH release by the incubated pituitary cells.
Subsonic loads on wings having sharp leading edges and tips (1976)

A vortex-lattice method for predicting the aerodynamics of wings having separation at the sharp edges in incompressible flows is extended to compressible subsonic flows using a modified Prandtl-Glauert transformation. Numerical results showing the effect of freestream Mach number on the aerodynamic coefficients are compared with available experimental data for several planforms. It is shown that the proposed method is suitable for predicting the aerodynamic loads on low-aspect wings at moderate angles of attack for high subsonic freestream Mach number. The method is limited to angles of attack up to 12 deg for high subsonic freestream Mach number and to angles of attack up to 20 deg for Mach number not exceeding 0.5.
Corrigendum: Synthesis, Structure and Catalytic Activity of NHC–AgI Carboxylate Complexes (2016)

The authors would like to apologize for an error in their recently published manuscript. On p. 13323, on the last paragraph of the left column, it was stated that: “The chemical shifts of the C2 carbenic carbon for the homologous series of the imidazol-2- ylidene complexes 1, 3, 5, and 6 are all found slightly downfield at about 184 ppm…” The bolded ′downfield′ should be ′upfield′. The full paragraph should now read: “The chemical shifts of the C2 carbenic carbon for the homologous series of the imidazol-2- ylidene complexes 1, 3, 5, and 6 are all found slightly upfield at about 184 ppm compared to the C2 shift of the SIPr complexes 2 a–d (207.9 ppm), whereas the C2 resonance of the IAd complexes 4 a and 4 b was recorded upfield at 173.5 ppm.”
Compound semiconductor nanowires for optoelectronic device applications (2011)

We review GaAs and InP nanowires and GaAs based nanowire heterostructures grown on (111)B substrates by metal organic chemical vapor deposition via vapor-liquid-solid (VLS) mechanism. Transmission electron microscopy, time-resolved photoluminescence and micro-Raman spectroscopy have been used to understand the crystal structure, carrier lifetime and strain effects on the bandgap energy.
CH<sub>3</sub>OH laser line assignments revisited (1983)

The CH <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> OH line frequencies calculated by diagonalizing the molecular Hamiltonian are affected by inaccuracies of the order of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−3</sup> ∼ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−2</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> or higher, the inaccuracy increasing with the values of the quantum numbers involved in the line. The main sources of inaccuracy are the computational approximations and the fact that the best available molecular constants have beer evaluated from best fits of microwave data, which usually involve low quantum numbers only. These inaccuracies and the richness of the methanol spectrum generate several ambiguities in the line assignments, in particular in the assignment of the far infrared (FIR) lines of the CH <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> OH laser. In order to overcome these ambiguities we have started a systematic investigation of the Fourier absorption spectrum of methanol in the regions between 8 and 80 and between 950 and 1100 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> . The peak precisions of our Fourier spectra are 2×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−4</sup> and 5×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−4</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> respectively for the two spectral regions (1). With such precisions and with definite assignments for the absorption lines it is possible to form loops of lines containing at least three absorption lines and closed by an investigated laser line. The balance of the frequencies involved in the loop must give zero within the experimental errors, this leading practically always to a unique choice for the assignment of the laser line. We have thus been able to prove or disprove several previous assignments, to make new assignments and to predict the frequencies of some possible FIR laser lines not yet observed.
Structural Studies on Phenylalanine Hydroxylase and Implications Toward Understanding and Treating Phenylketonuria (2003)

Mutations in the gene encoding for phenylalanine hydroxylase (PAH) result in phenylketonuria (PKU) or hyperphenylalaninemia (HPA). Several 3-dimensional structures of truncated forms of PAH have been determined in our laboratory and by others, using x-ray crystallographic techniques. These structures have allowed for a detailed mapping of the >250 missense mutations known to cause PKU or HPA found throughout the 3 domains of PAH. This structural information has helped formulate rules that might aid in predicting the likely effects of unclassified or newly discovered PAH mutations. Also, with the aid of recent crystal structure determinations of co-factor and substrate analogs bound at the PAH active site, the recently discovered tetrahydrobiopterin-responsive PKU/HPA genotypes can be mapped onto the PAH structure, providing a molecular basis for this tetrahydrobiopterin response.
Inflammatory cytokine and microRNA responses of primary human dendritic cells cultured with Helicobacter pylori strains (2013)

Primary human dendritic cells (DC) were used to explore the inflammatory effectors, including cytokines and microRNAs, regulated by Helicobacter pylori. In a 48 h ex-vivo co-culture system, both H. pylori B38 and B45 strains activated human DCs and promoted a strong inflammatory response characterized by the early production of pro-inflammatory TNFα and IL-6 cytokines, followed by IL-10, IL-1β, and IL-23 secretion. IL-23 was the only cytokine dependent on the cag pathogenicity island status of the bacterial strains. DC activation and cytokine production were accompanied by an early miR-146a upregulation followed by a strong miR-155 induction, which mainly controlled TNFα production. These results pave the way for further investigations into the nature of H. pylori antigens and the subsequently activated signaling pathways involved in the inflammatory response to H. pylori infection, the deregulation of which may likely contribute to gastric lymphomagenesis.
Analysis of Human Saliva Metabolome by Direct Immersion Solid-Phase Microextraction LC and Benchtop Orbitrap MS (2013)

Saliva may be useful for medical diagnostics as it is non-invasive. The use of biocompatible solid-phase microextraction fibers can play an important role as an alternative sample preparation method for untargeted LC-MS metabolomics studies on human saliva because it provides simultaneous extraction of metabolites with a wide range of polarity, thus allowing the detection of changes in metabolic pathways with unsupervised statistical analyses.
ChemInform Abstract: Two Complementary Methods for Introduction of gem‐Dimethyl Group in Hexopyranoside Ring. (1986)

Abstract Zwei sich ergänzende Verfahren zur Einführung geminaler Dimethylgruppen in Pyranosen werden beschrieben.
A formative evaluation of customized pamphlets to promote physical activity and symptom self-management in women with multiple sclerosis (2014)

Inactivity is a prevalent problem in the population affected with multiple sclerosis (MS). Thus, there is a need to develop and test physical activity (PA) interventions that can be widely disseminated. We conducted a formative evaluation as part of a randomized controlled trial of a pamphlet-based PA intervention among 30 women with MS. Pamphlets were customized to sub-sets of participants who shared similar symptoms and barriers to PA. Mixed methods were used to examine the intervention's influence on self-efficacy, social support, processes of change and stages of change placement, as well as explore participants' perceived barriers, motivators and strategies for engaging in a PA program. Results indicated that the intervention group significantly improved stages of change placement (F = 16.64, P < 0.01) and social support (F = 4.08, P = 0.05) in comparison to the control group. Fatigue, pain and lack of time were the commonly cited barriers to engage in the PA program; whereas the pamphlets, phone calls and action planning were cited as motivators. Participants used fatigue management strategies, enlisted social support and modified their environment to routinely engage in the PA program. Strategies were identified to improve the PA intervention in future research.
Characterization Of Composites With Flax Fibers Treated With Cold Plasma-Water Permeation And Thermal Analysis (2005)

(2005). Characterization Of Composites With Flax Fibers Treated With Cold Plasma-Water Permeation And Thermal Analysis. Materials Research Innovations: Vol. 9, No. 1, pp. 15-17.
Correct structures of montanin C, teupolin I, and 12-epiteucvin, three (12R)-neoclerodan-20, 12-olides isolated from the Teucrium species (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrect structures of montanin C, teupolin I, and 12-epiteucvin, three (12R)-neoclerodan-20, 12-olides isolated from the Teucrium speciesJose Fayos, Francisco Fernandez-Gadea, Conrad Pascual, Aurea Perales, Franco Piozzi, Manuel Rico, Benjamin Rodriguez, and Giuseppe SavonaCite this: J. Org. Chem. 1984, 49, 10, 1789–1793Publication Date (Print):May 1, 1984Publication History Published online1 May 2002Published inissue 1 May 1984https://doi.org/10.1021/jo00184a023Request reuse permissionsArticle Views121Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (584 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts