gebhart/patrepeval huggingface dataset:
Regulation of cell adhesion using a signal‐responsive membrane substrate (2005)

We have developed a novel cell culture material that regulates cell adhesion by changes in potassium ion concentration. The material is a polyethylene substrate grafted to a copolymer of the thermoresponsive polymer N-isopropylacrylamide (NIPAM) and benzo-18-crown- 6-acrylamide (BCAm), with a pendant crown ether as sensor. The crown ether recognizes potassium ion concentrations and NIPAM conformational changes lead to changes in the hydrophobicity/hydrophilicity balance of the entire polymer at constant cell culture temperatures. Although cells were successfully cultured on the ion recognition material in normal culture medium at 37 degrees C, the cells could be detached from the material surface by adding potassium ions alone, without proteolytic enzymes, because the surface to which the cells were attached altered its surface characteristics to a more hydrophilic state. Therefore, cell layers with intact cell-to-cell junctions and high activities were successfully recovered. Furthermore, by changing the target sensors, this material will be able to control cell adhesion through various cellular signals.
236mW average second-harmonic power generated from periodically poled silica fibres (2009)

In this work, the generation of as much as 236 mW single-mode second-harmonic (SH) light from a periodically poled fibre (PPSF) pumped by a high power fibre laser is demonstrated. The PPSF device was fabricated by the insertion of wire electrodes into the holes of a specialty twin-hole germanosilicate fibre. The acceptance bandwidth of the device was measured to be 0.46 nm in agreement with theoretical predictions. From this measurement, the normalised conversion efficiency was estimated to be 7.34x10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> %/W.
Association of Type I DNA Topoisomerase with Herpes Simplex Virus (1985)

A topoisomerase activity is associated with herpes simplex virus type 1. The enzyme was recovered from purified virions which were disrupted with 6 M-guanidine-HCl followed by renaturation of extracted proteins. Based upon the following observations, the virion activity is classified as a type I topoisomerase: (i) the linking number of a unique DNA topoisomer is altered in steps of one; (ii) ATP and MgCl2 are not required for activity; (iii) the enzyme can be trapped in a covalent complex with DNA; (iv) the covalent linkage to DNA is through a 3' phosphoryl bond. A number of lines of evidence strongly indicate that the topoisomerase is external to the nucleocapsid. For example, the activity was released by treatment of intact virions with NP40, and subsequent washing steps extracted most residual activity. When guanidine extracts were prepared from nucleocapsids, topoisomerase activity was not detectable. Finally, DNA within the virion did not appear to contain covalently attached proteins with properties similar to topoisomerases. Thus, the enzyme appears to be a component of the envelope or tegument structure of the virion.
Provisioning Link Layer Proportional Service Differentiation in Wireless Networks with Smart Antennas (2005)

In this paper, we present a collision free MAC protocol for wireless networks with smart antennas that provides proportional service differentiation to various classes of traffic based on their respective bandwidth demand. The proposed protocol works for diverse physical parameters such as number of interfaces at each node, number of communication frequencies, and antenna beamwidth. To the best of our knowledge, this is the first work that provides link layer differentiated services for wireless networks with smart antennas and explores the influence of the physical parameters and network topology on the performance of the MAC layer.
Isolation of recombinants doubly and triply drug-resistant to streptomycin, tetracycline and chloramphenicol by PEG-induced cell fusion of singly resistant staphylococcus aureus L-forms. (1982)

Various combinations of four substrains of Staphylococcus aureus L-form (strain STA-EMT-1), each of which was resistant to one of the following four drugs, streptomycin (SM), tetracycline (TC), chloramphenicol (CP) and erythromycin (EM), were submitted to polyethylene glycol (PEG)-induced cell fusion. PEG-induced cell fusion followed by enrichment culture in the liquid basal medium supplemented with penicillin G resulted in development of recombinants that were doubly drug-resistant to SM and TC, SM and CP, and TC and CP, but no recombinant doubly resistant to EM and TC, was obtained by treatment of a EM-resistant and TC-resistant substrains with PEG. No recombinants resistant to SM, CP and TC could be obtained by treatment of substrains resistant to SM, CP and TC, respectively, with PEG. But recombinants triply resistant to these three drugs were produced by two-step cell fusion; that is by fusion of a recombinant doubly resistant to two of the three drugs with a substrain resistant to the third drug.
Duodenal Secretomotor Function in Untreated Coeliac Disease (1995)

The results suggest that in untreated coeliac disease, active chloride secretion is enhanced, and Na+/H+ exchange is reduced. This remodelled mucosa still seems to respond to neurogenic stimuli, as suggested by the presence of MMC-related changes in secretion rate.
Light‐ and phytochrome‐mediated gene expression in Douglas‐fir seedlings (1992)

In dark‐grown Douglas‐fir [Pseudotsuga menziesii (Mirb.) Franco] seedlings, the steady‐state level of the major light‐harvesting chlorophyll a/b binding proteins mRNA (cab mRNA) was about 25% of the level that accumulated in light‐grown seedlings. A single, 5‐min irradiance with red light up‐regulated expression transiently, so that cab mRNAs accumulated to a Jevel approaching that determined for light‐grown seedlings. The response was reversible by far‐red light to the dark level, indicating that the up‐regulation was a phytochrome‐mediated response. Phytochrome action also up‐regulated genes that encode ribulose bisphosphate carboxylase/oxygenase (EC 4.1.1.39) ( rbcS ) in Douglas‐fir seedlings, but the maximal rbcS mRNA level that was attained after the red light treatment was several‐fold lower than the expression level deternined for light‐grown seedlings. Genes that produce ubiquitin and ubiquitin‐fusion transcripts were differentially expressed in dark‐ and light‐grown seedlings, but the genes did not appear to be phytochrome regulated.
Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy. (2000)

Missense mutations of the lamin A/C gene, LMNA, have been recently identified in Dunnigan-type familial partial lipodystrophy (FPLD), which belongs to a heterogeneous group of rare disorders affecting adipose tissue distribution and metabolism. In this study, we sequenced the LMNA coding region from patients presenting with FPLD or other forms of lipodystrophy. We identified two heterozygous mutations in exon 8, R482W and R482Q, in FPLD patients (six families and one individual) with various clinical presentations. In addition, we found a novel heterozygous mutation (R584H) in exon 11, encoding specifically the lamin A isoform, in a patient with typical FPLD. Clinical and biochemical investigations in FPLD patients revealed that the expression and the severity of the phenotype were markedly dependent on sex, with female patients being more markedly affected. In subjects with generalized lipoatrophy, either congenital (13 case subjects) or acquired (14 case subjects), or Barraquer-Simon syndrome (2 case subjects), the entire LMNA coding sequence was normal. Although FPLD mutations are predominantly localized in exon 8 of LMNA, the finding of a novel mutation at codon 584, together with the R582H heterozygous substitution recently described, confirms that the C-terminal region specific to the lamin A isoform is a second susceptibility region for mutations in FPLD.
Exciton and polaron dynamics in a step-ladder polymeric semiconductor: the influence of interchain order (2002)

We present combined results of femtosecond transient photoluminescence (PL), femtosecond transient absorption and quasi-steady-state photoinduced absorption spectroscopy on the organic semiconductor poly-6, 6', 12, 12'-tetraalkyl-2, 8-indenofluorene (PIF). By control of interchain order via the choice of the side-chain substituents, we have investigated its effect on exciton and polaron dynamics in this model electronic material. We show that interfaces between ordered and disordered domains play a significant role in the photophysics. At high photoexcitation fluence, a high yield (∼10%) of polarons is only observed in the ordered semiconductor. This process arises from two-step photoexcitation, first to the lowest exciton, and then to a high-energy state of opposite symmetry. In contrast, triplet exciton population is generated via sequential excitation with smaller yield (< 1 %) in both ordered and disordered materials. In the low fluence regime, triplet excitons are found to arise from evolution of polarons generated with low efficiency (also < 1 %) by diffusion-limited processes. The triplet generation yield is strongly dependent on order, with the disordered material displaying a higher yield. Polaron decay is found to be thermally activated, with a higher activation energy and lower room-temperature recombination rate in the ordered material. Furthermore, we do not find that emissive keto defects play a defining role in the PL properties of our PIF samples. Instead, absorption features of aggregate-like species, which we believe to lead to sub-gap emission, are evident in the photocurrent action spectrum of the more ordered PIF derivative.
A novel framework for Scalable Pattern-driven image compression (2008)

This paper presents a novel multi-filtering framework for achieving Scalable PAttern-driven Region-adaptive Compression (SPARC) of imagery. Based on a pattern-driven image perception, SPARC achieves efficient compression by modeling and encoding different (simple, structural and complex) visual patterns. Experimental results using various image datasets and comparison with the latest image compression standard corroborate the feasibility and efficiency of the SPARC technique.
Atopic sensitization among children in an Arctic environment (2002)

Compared with European findings Greenlandic children have high levels of total IgE but a low prevalence of allergic sensitization towards inhalant allergens. This may be due to a low genetic susceptibility to atopy and less allergen exposure, as well as to living conditions in an arctic environment.
Oxygen-17 nuclear quadrupole double resonance spectroscopy (1978)

The Slusher–Hahn technique for detection of nuclear quadrupole transitions of low abundance spins at zero magnetic field is briefly described. Factors affecting the observed line shapes are discussed. The 17O n.q.r. spectra for a variety of substances studied at 77 K are presented. The results for several compounds are discussed in terms of the Townes–Dailey model, which leads to an assignment of oxygen 2p orbital populations.
Activation and Oxidation of Acetic Acid-1-C<sup>14</sup> by Cell Free Homogenates of Germinating Peanut Cotyledons (1965)

1. BARRON, E. J. AND P. K. STUMPF. 1962. Fat metabolism in higher plants. XIX. The biosynthesis of triglycerides by avocado-mesocarp enzymes. Biochim. Biophys. Acta 60: 329-37. 2. BUCHANAN, M. A. 1959. Paper chromatography of the saturated fatty acids. Anal. Chem. 31: 1616-18. 3. CHERRY, J. H. 1963. Nucleic acid, mitochondria, and enzyme changes in cotyledons of peanut seeds during germination. Plant Physiol. 38: 440-46. 4. DALTON, A. J. 1955. A chrome-osmium fixative for electron microscopy. Anat. Record 121: 281. 5. GORNALL, A. G., C. J. BARDAWILL, AND M. M. DAVIS. 1949. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177: 75166. 6. KORNBERG, A. AND W. E. PRICER, JR. 1953. Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids. J. Biol. Chem. 204: 329-43. 7. MARCUS, A. AND J. VELASCO. 1960. Enzymes of the glyoxylate cycle in germinating peanuts and castor beans. J. Biol. Chem. 235: 563-67. 8. MANGOLD, H. K., B. G. LAMP, AND H. SCHLENK. 1955. Indicators for paper chromatography of lipids. J. Am. Chem. Soc. 77: 607-72. 9. REBEIz, C. A. AND P. CASTELFRANCO. 1964. An extra-mitochondrial enzyme system from peanuts catalyzing the (3-oxidation of fatty acids. Plant Physiol. 39: 932-38. 10. STUMPF, P. K. Private communication.
Principles of cost/benefit ratios (2003)

info:eu-repo/semantics/published
The National Temporal Bone, Hearing, and Balance Pathology Resource Registry (1993)

• The National Temporal Bone, Hearing, and Balance Pathology Resource Registry has been established with funding provided by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health. The registry is meant to serve as a national resource for researchers and the public to stimulate and facilitate human otopathologic research. It will maintain a computerized database of currently active and inactive temporal bone and auditory brain-stem collections throughout the United States. In addition, it will encourage human temporal bone research by disseminating pertinent information, developing and fostering temporal bone professional educational activities, implementing a national temporal bone acquisition network, and encouraging investigative collaborations in the study of the human temporal bone and brain structures. It will also identify otopathologic collections at risk of being discarded or lost and will develop mechanisms and strategies to conserve them. (<i>Arch Otolaryngol Head Neck Surg.</i>1993;119:846-853)
Ensemble-tight error exponents for mismatched decoders (2012)

This paper studies channel coding for discrete memoryless channels with a given (possibly suboptimal) decoding rule. Using upper and lower bounds on the random-coding error probability, the exponential behavior of three random-coding ensembles is characterized. The ensemble tightness of existing achievable error exponents is proven for the i.i.d. and constant-composition ensembles, and a new ensemble-tight error exponent is given for the cost-constrained i.i.d. ensemble. Connections are drawn between the ensembles under both mismatched decoding and maximum-likelihood decoding.
Inelastic Scattering of Electrons from the 19.08-MeV Level in Oxygen-16 (1967)

The form factor for the 19.08-MeV level in oxygen-16 has been measured for momentum transfers between 60 and $260 \frac{\mathrm{MeV}}{c}$. The results, when compared with particle-hole calculations, strongly support an assignment $J=2$. Since the transition is transverse, the parity is negative, and the assignment to the level is ${J}^{\ensuremath{\pi}}={2}^{\ensuremath{-}}$.
Physiological role of pyruvate oxidase in the aerobic metabolism of Lactobacillus plantarum (1984)

Under aerobic growth conditions Lactobacillus plantarum produced acetic acid in addition to lactic acid. It was found that lactic acid was predominantly produced at first, and then when the carbohydrate was nearly exhausted, lactic acid was metabolized further to acetic acid. The most likely enzyme involved in the aerobic metabolism of L. plantarum is pyruvate oxidase. Its activity is enhanced in the presence of oxygen and is reduced in the presence of glucose. The specific activity of pyruvate oxidase is highest at the beginning of the stationary-growth phase, where a strong increase in acetic acid production was also observed.
Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes (2008)

We conclude that parameters such as tissue specificity and network connectivity can be used in combination to identify a group of genes, not previously confirmed as disease causing, that are involved in interactions with disease causing genes. Our guilt-by-association algorithm should be useful for the discovery of additional modifiers of genetic diseases, and more generally, for the ability to associate genes of unknown function to clusters of genes with defined functions allowing for novel biological inference that can be subsequently validated.
An isothermal bath for use in the temperature range 200-500 C (1955)

A constant-temperature bath having excellent control and stability characteristics has been constructed. A molten 50-50 wt% mixture of sodium nitrate and sodium nitrite, vigorously stirred, was used as the bath liquid. An electronically balanced Wheatstone bridge, operated in conjunction with a platinum resistance thermometer, controlled the bath temperature; a second resistance thermometer served to monitor the temperature. Temperature fluctuations of ±0.025° C at 400° C were observed over a period of 500 h, but control to ±0.01° C could be attained for shorter periods of time.
Arrhythmogenic Effects of Quinidine on Catecholamine‐Induced Delayed Afterdepolarizations in Canine Atrial Fibers (1990)

Arrhythmogenic Effects of Quinidine on Catecholamine‐induced Delayed Afterdepolarizations . We studied the effects of quinidine and tetrodotoxin (TTX), two drugs that block Na + channels, on delayed afterdepolarizations (DAD) caused by norepinepbrine in atrial fibers of the canine coronary sinus. At long stimulus cycle lengths of 10 seconds, quinidine increased the amplitude of the afterdepolarizations and caused triggered activity within 1–2 minutes. Simultaneously, action potential duration (APD) was lengthened but upstroke velocity was not decreased. Prolonged exposure to quinidine eventually decreased upstroke velocity but DAD amplitude remained larger than control and triggered activity was still induced more easily. The effects of quinidine to increase afterdepolarizations was partially related to its prolongation of the APD since shortening APD with repolarizing current decreased DAD amplitude. However, DAD amplitude remained larger than control indicating that quinidine caused triggering by other mechanisms as well. TTX, on the other hand, which blocks Na + channels but shortens APD, decreased DAD amplitude and triggered activity. Part but not all of these effects resulted from the shortening of APD by TTX since prolongation of APD with depolarizing current only partially restored DAD amplitude. Anti‐arrhythmic drugs, therefore, may have effects on DADs that partly result from changes in the APD. Quinidine may cause cardiac arrhythmias by virtue of its effects to potentiate triggered activity.
Characterization of Chlorovinylcobalamin, A Putative Intermediate in Reductive Degradation of Chlorinated Ethylenes (2003)

The first X-ray structure of a vinylcobalamin is reported. Chlorovinylcobalamin is formed in the reaction of cob(I)alamin with chloroacetylene. Subsequently, cob(I)alamin catalyzes the reduction of chlorovinylcobalamin to vinylcobalamin in the presence of excess titanium(III)citrate. Introduction of a chlorine onto the vinyl group of vinylcobalamin greatly changes its reduction potential. These results are discussed with respect to vitamin B12-catalyzed dechlorination of perchloroethylene, a pollutant on the priority list of the EPA.
Improvements to the Or-opt heuristic for the symmetric travelling salesman problem (2006)

Several variants and generalizations of the Or-opt heuristic for the Symmetric Travelling Salesman Problem are developed and compared on random and planar instances. Some of the proposed algorithms are shown to significantly improve upon the standard 2-opt and Or-opt heuristics.
Thermal conductivity reduction in fullerene‐enriched p‐type bismuth telluride composites (2009)

Abstract We present a systematic study of the effects of fullerene nanoinclusions upon a p‐type bismuth–antimony–telluride matrix, where the ultimate goal is maximizing the figure of merit by reducing the thermal conductivity (TC). Nanocomposites consisting of a bismuth–telluride matrix with fullerene inclusions have been prepared both by mechanical mixing and ball milling, with the final consolidation in each case achieved by uniaxial hot pressing. A series of samples was produced with fullerene concentrations ranging from fractional levels to several molar percent, and the effects of the fullerene additions upon the resulting microstructure have been considered. Thermal and electrical transport properties have been measured from 10 to 300 K, and the data are discussed in light of the underlying physical mechanisms.
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2 (2000)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2John J. Talley, David L. Brown, Jeffery S. Carter, Matthew J. Graneto, Carol M. Koboldt, Jaime L. Masferrer, William E. Perkins, Roland S. Rogers, Alexander F. Shaffer, Yan Y. Zhang, Ben S. Zweifel, and Karen SeibertView Author Information Searle Research and Development, 700 Chesterfield Parkway, St. Louis, Missouri 63198, and 4901 Searle Parkway, Skokie, Illinois 60077 Cite this: J. Med. Chem. 2000, 43, 5, 775–777Publication Date (Web):February 23, 2000Publication History Received17 November 1999Published online23 February 2000Published inissue 1 March 2000https://pubs.acs.org/doi/10.1021/jm990577vhttps://doi.org/10.1021/jm990577vrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views2297Altmetric-Citations527LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antiinflammatories,Assays,Inflammation,Inhibitors,Peptides and proteins Get e-Alerts