gebhart/patrepeval huggingface dataset:
Assessment of MAO-B Occupancy in the Brain With PET and [11C]-L-Deprenyl-D2: A Dose-Finding Study With a Novel MAO-B Inhibitor, EVT 301 (2009)

Inhibition of monoamine oxidase type B (MAO-B) activity in the brain is a putative strategy for the treatment of Alzheimer's disease (AD). We performed a dose-selection and validation study of a novel, reversible MAO-B inhibitor, EVT 301. Sixteen healthy volunteers received selegiline (10 mg) or EVT 301 (25, 75, or 150 mg) daily for 7-8 days, and four subjects with AD received 75 mg of EVT 301. MAO-B occupancy in the brain was assessed using positron emission tomography (PET) with [11C]-L-deprenyl-D2. EVT 301 was found to dose-dependently occupy MAO-B in the human brain, with occupancy ranging from 58-78% at a dose of 25 mg to 73-90% at a dose of 150 mg. The corresponding occupancy after selegiline was 77-92%. Determination of MAO-B inhibition in blood platelets underestimated the actual brain occupancy achieved with EVT 301. A daily EVT 301 dose of 75 or 150 mg appears suitable for clinical efficacy studies in patients with AD.
Polarization of Ethylene Dichloride in Benzene (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarization of Ethylene Dichloride in BenzeneArthur A. Vernon and Elbert V. KringCite this: J. Am. Chem. Soc. 1949, 71, 5, 1888–1889Publication Date (Print):May 1, 1949Publication History Published online1 May 2002Published inissue 1 May 1949https://pubs.acs.org/doi/10.1021/ja01173a529https://doi.org/10.1021/ja01173a529research-articleACS PublicationsRequest reuse permissionsArticle Views20Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Comparison of midgut bacterial community between Bt-resistant and sensitive Helicoverpa armigera]. (2010)

The midgut bacterial community of resistant and sensitive H. armigera was similar, which had no direct effect on Bt-resistance of H. armigera.
Structure–Charge Transport Relationships in Fluoride-Doped Amorphous Semiconducting Indium Oxide: Combined Experimental and Theoretical Analysis (2019)

Anion doping of transparent amorphous metal oxide (a-MO) semiconductors is virtually unexplored but offers the possibility of creating unique optoelectronic materials owing to the chemical tuning, modified crystal structures, and unusual charge-transport properties that added anions may impart. We report here the effects of fluoride (F–) doping by combustion synthesis, in an archetypical metal oxide semiconductor, indium oxide (In–O). Optimized fluoride-doped In–O (F:In–O) thin films are characterized in depth by grazing incidence X-ray diffraction, X-ray reflectivity, atomic force microscopy, X-ray photoelectron spectroscopy, and extended X-ray absorption fine structure (EXAFS). Charge-transport properties are investigated in thin-film transistors (TFTs), revealing that increasing fluoride content (0.0 → 1.57 atom %) slightly lowers the on-current (Ion) and electron mobility due to scattering from loosely bound F– centers but enhances important TFT performance parameters such as the Ion/Ioff ratio, subthreshold swing, and bias stress stability, yielding superior TFT switching versus undoped In–O. These results are convincingly explained by ab initio molecular dynamics simulations and density functional theory electronic structure calculations. Combined with the EXAFS data, the experimental and theoretical results show that F– hinders crystallization by enhancing the local and medium-range disorder, promotes a uniform film morphology, and favors the formation of deeper, more localized trap states as compared to F–-free In–O. These data also show that the local organization and electronic structure of amorphous F–-doped oxide semiconductors are significantly different from those of F–-doped crystalline oxide semiconductors and suggest new avenues to further modify a-MOs for enhanced optoelectronic properties.
Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy (2015)

These findings suggest that circulating miRNAs provide attractive candidates as putative biomarkers for diffuse myocardial fibrosis in HCM.
Electrical power extraction from standing shock waves (1980)

We have generated potentials of typically 1 V and extracted currents of several hundred millilamps from standing shock waves generated by imbedding wedge-shaped obstacles in supersonic flow.
A Correlation of Stream Potentials and Surface Conductance (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Correlation of Stream Potentials and Surface ConductanceH. L. WhiteH. L. WhiteMore by H. L. White, Frank UrbanFrank UrbanMore by Frank Urban, and E. A. Van AttaE. A. Van AttaMore by E. A. Van AttaCite this: J. Phys. Chem. 1932, 36, 12, 3152–3156Publication Date (Print):December 1, 1932Publication History Published online1 May 2002Published inissue 1 December 1932https://doi.org/10.1021/j150342a025RIGHTS & PERMISSIONSArticle Views37Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (369 KB) Get e-Alerts
Knotting of a pulmonary artery catheter in the superior vena cava: surgical removal and a word of caution (2004)

A case of postoperative pulmonary artery catheterisation complicated by knotting of the catheter (Swan-Ganz) within the superior vena cava is described. The catheter was cut off at the skin entry site. The remainder, together with the knot, was pulled out through a purse string incision in the superior vena cava.
The Retinoblastoma Gene and its Significance (1994)

The first human tumour suppressor gene, the Retinoblastoma Susceptibility gene (RB1) was first demonstrated in retinoblastoma, a rare paediatric eye tumour which has been studied extensively over the last century. Genetic studies of retinoblastoma have yielded unique insights into familial cancer syndromes and the mechanisms of oncogenesis by tumour suppressor genes such as the RB1 gene. In this view, we will summarize past research into the genetics of retinoblastoma that led to the discovery of the RB1 gene and discuss the influence these results have had on the field of cancer research. In addition, we will discuss current research into RB1 as it relates to cancer and its potential for new therapies.
Electric Double Layer Capacitor of Multiwall Carbon Nanotubes under Different Degree of Acid Oxidations (2014)

Carbon nanotubes (CNT) are a material with unique properties (mechanical, electrical, electrochemical, etc) allied with low density and high specific area. The present paper studied the electrochemical properties of carbon nanotubes growth by Chemical Vapor Depostion (CVD) technique. The samples were characterized by SEM, Raman Spectroscopy and the double layer capacitance of the powders was evaluated in a Teflon capacitor system with a Ag/AgCl (3M) as reference electrode. The catalyst remotion is provided in Hydrochloric acid washing and the wet oxidative treatments promotes the CNT oxidation and increase the pseudocapacitive response.
Off‐resonance metabolite magnetization transfer measurements on rat brain in situ (1999)

Off-resonance metabolite magnetization transfer (MT) experiments were performed on rat brain in vivo and post mortem, with short (18 msec) and long (144 msec) echo-time 1H nuclear magnetic resonance (NMR) spectroscopy. In vivo and post mortem, the methyl protons of total creatine and all protons from glutamate/glutamine showed a strong MT effect on off-resonance saturation, as well as the methyl protons from lactate post mortem. Other resonances, like that of N-acetyl aspartate, showed a much smaller, but detectable, MT effect. The results obtained were confirmed by combining off-resonance saturation with two-dimensional correlation spectroscopy. Three water suppression techniques, i.e., presaturation, chemical shift-selective (CHESS), and selective water eliminated Fourier transform (WEFT) were evaluated for their ability to generate an MT effect, to assess their possible influence on metabolite quantification. Presaturation and selective WEFT led to alterations of the total creatine, lactate, and N-acetyl aspartate resonance intensities, while CHESS had no effect. Finally, it was shown that water protons play an important role in the generation of the observed metabolite MT effects. Magn Reson Med 41:1136–1144, 1999. © 1999 Wiley-Liss, Inc.
The biochemical basis for the species difference in hepatic microsomal 4-vinylcyclohexene epoxidation between female mice and rats (1990)

Mice but not rats are susceptible to 4-vinylcyclohexene (VCH)-induced ovarian toxicity and carcinogenicity. This is due in part to a 4- to 6-fold greater rate of hepatic microsomal bioactivation of VCH to the ovotoxicant VCH-1,2-epoxide. The biochemical basis for this difference was investigated in microsomes using enzyme induction, enzyme inhibition with chloramphenicol or specific inhibitory antibodies, and correlation with marker steroid hydroxylase activities to associate VCH epoxidation with particular cytochrome P450 forms. Testosterone 6 beta- and 15 alpha-hydroxylase activities and VCH epoxidation were decreased in microsomes from chloramphenicol-treated mice, initially suggesting the possible involvement of P450IIIA and P450IIA forms in VCH metabolism. Although both testosterone 6 beta-hydroxylase and VCH epoxidase activities were increased by dexamethasone treatment (P450IIIA inducer), anti-rat P450IIIA IgG inhibited testosterone 6 beta-hydroxylase (68%) but not VCH epoxidase activity. These latter results do not support the involvement of mouse P450IIIA forms in VCH epoxidation. However, results were obtained which indicated that mouse P450IIA forms are involved in VCH epoxidation. In microsomes from untreated female mice VCH epoxidase activity was inhibited 48% by antibodies to mouse P45015 alpha (P450IIA3) at a concentration that inhibited testosterone 15 alpha-hydroxylase activity by 86%. No protein immunochemically related to mouse P45015 alpha was detected in female rat hepatic microsomes. VCH epoxidation by hepatic microsomes was increased in female mice and rats by phenobarbital treatment and was inhibited by approximately one-third by anti-rat-P450IIB1 IgG in microsomes from untreated animals of both species. Furthermore, microsomal VCH epoxidase and testosterone 16 alpha-hydroxylase activities were lower (34%) in female 129/J mice (deficient in constitutive expression of P450IIB forms) than in B6C3F1 mice. These results suggested partial involvement of P450IIB forms in the microsomal epoxidation of VCH. Therefore, P450 forms IIA and IIB account for the majority of VCH bioactivation in female mouse liver, which explains in part the susceptibility of mice to VCH-induced ovarian toxicity and carcinogenicity.
Synthese neuer verzweigter Fettsäureester durch homogene Rhodiumkatalyse (1991)

Abstract Verzweigte Fettsäurederivate weisen im Vergleich zu den homologen geradkettigen Fettsäurederivaten ungewöhnliche physikalische Eigenschaften auf. Sie finden als Schmierstoffkomponenten, in Kosmetika, als Weichmacher, Entschäumer und Holzschutzmittel vielfältige Anwendungen. Eine homogenkatalysierte Reaktion wird vorgestellt, durch die erstmals gezielt innenständig alkylverzweigte Fettsäurederivate in Ausbeuten bis zu 95% hergestellt werden können. Die Synthese erfolgt durch eine Rhodiumkatalysierte Addition kurzkettiger Olefine an Linolsäure‐ bzw. Konjuensäureester.
Distance Perception in Insects (1992)

motor agility enigmatic. Unlike vertebrates, insects have immobile eyes with fixed-focus op tics. The absence of eye movements implies that the range of an object cannot be inferred from the extent to which the directions of gaze of the two eyes must converge to view the object. The inability of an insect eye to change focus means that the dis tance to an object cannot be esti mated by monitoring the refractive power that is required to bring the ?mage of the object into focus on the retina. Compared with human eyes, the eyes of insects are positioned much closer together, and possess much poorer spatial acuity, so the precision with which insects could estimate range through binocular stereopsis?even if they possessed the requisite neural apparatus? would be much poorer and re stricted to relatively small dis tances.1 So far, the praying mantis is the only insect in which stereopsis has been demonstrated unequivo cally.2 It has widely separated eyes, and uses stereoscopic cues to deter
Synthesis and Antitumor Activity of 9-(Tetrahydro-2-furyl)purine Analogs of Biologically Important Deoxynucleosides<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Antitumor Activity of 9-(Tetrahydro-2-furyl)purine Analogs of Biologically Important Deoxynucleosides1William A. Bowles, F. Howard Schneider, Leland R. Lewis, and Roland K. RobinsCite this: J. Med. Chem. 1963, 6, 5, 471–480Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://pubs.acs.org/doi/10.1021/jm00341a002https://doi.org/10.1021/jm00341a002research-articleACS PublicationsRequest reuse permissionsArticle Views397Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nuclear Localization Signals of the E-Cadherin Transcriptional Repressor Snail (2007)

The E-cadherin transcriptional repressor, Snail, plays a critical role in driving the epithelial-mesenchymal transition programs that mark gastrulation as well as invasion of cancer cells. Recent data suggest that Snail is phosphorylated by GSK3-beta, resulting in beta-TRCP-mediated ubiquitination and proteasomal degradation. Accordingly, Wnt signaling inhibits Snail phosphorylation, and consequently increases Snail protein levels. In the present study, we examine the function of nuclear localization motifs embedded within the Snail sequence. A typical bipartite nuclear localization signal (NLS) motif is located at the N-terminal of Snail, where it overlaps with the SNAG domain (residues 8-16), while a basic cluster NLS motif is found proximal to zinc finger domains (residues 151-152). Mutational inactivation of these NLS signals resulted in decreased levels of nuclear and total Snail protein as well as attenuated Snail repressor activity on an E-cadherin promoter construct, suggesting that NLS motifs are essential for proper function. In the presence of GSK3 inhibitor LiCl, the cytoplasmic levels of the NLS mutants increased, suggesting that cytosolic Snail undergoes rapid phosphorylation and degradation. Given the highly conserved nature of the Snail NLS motifs (from Xenopus to human), these results indicate that nuclear localization signals regulate Snail expression and subcellular localization via GSK3-beta-dependent phosphorylation.
Manufacture of Unidirectional Carbon Fiber Reinforced Carbon Composites by Preformed-Yarn Method (1999)

A bundle of polyacrylonitrile-based carbon fibers was included in a matrix precursor composed of fine pitchcoke and mesophase pitch, and was coated with polypropylene, resulting in a preformed yarn (PY). Unidirectional (UD) PY sheets, prepared by aligning the PYs, were stacked. Hot press molding of the staked UD-PY sheets at 600°C and heat treatment up to 2000°C were performed to manufacture a UD-C/C composite. Density, porosity, flexuralstrength and modulus of the resulting UD-C/C composite test pieces were measured. Flexural strength and modulusof the UD-C/C composite test pieces manufactured from PY with 40wt% pitch coke in its matrix precursor were487.3MPa and 125.4GPa, respectively. Even without impregnation, these value were superior by a factor of about 1.3than the UD-C/C composites manufactured by conventional method using phenol resin as a main component of matrixprecursor. Microstructural inspections of cross sections of the test pieces were also carried out. Any kind of pore werehardly recognized and a good fiber/matrix bonding was formed in the matrix of the UD-C/C composites manufactured from PY with 40wt% pitch coke in its matrix precursor.
The origins of computer programming (1994)

This article describes some of the early developments that can now be viewed as steps toward the development of program control and the modern concept of a stored program. In particular, it discusses early automatic devices, Babbage's contributions set against a background of the technology of his day, the contributions of some of his direct successors, and the genesis of the stored-program idea.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: STEREOSELECTIVE BROMINATION OF ALLYLIC ALCOHOLS. A FACILE SYNTHESIS OF (E)‐ OR (Z)‐BROMO EPOXIDES FROM A COMMON STARTING MATERIAL (1981)

Abstract Aus den stereoisomeren Allylalkoholen (I) erhält man bei der Bromierung unter weitgehendem Erhalt der Konfiguration über die Addukte (II) die isomeren Brom‐epoxide (III) und (IV).
The Welfare Economics of Default Options in 401(k) Plans (2011)

Default contribution rates for 401(k) pension plans powerfully influence workers' choices. Potential causes include opt-out costs, procrastination, inattention, and psychological anchoring. We examine the welfare implications of defaults under each of these theories. We show how the optimal default, the magnitude of the welfare effects, and the degree of normative ambiguity depend on the behavioral model, the scope of the choice domain deemed welfare-relevant, the use of penalties for passive choice, and other 401(k) plan features. Depending on which theory and welfare perspective one adopts, virtually any default contribution rate may be optimal. Still, our analysis provides reasonably robust justifications for setting the default either at the highest contribution rate matched by the employer or -contrary to common wisdom -at zero. We also identify the types of empirical evidence needed to determine which case is applicable.
WATERSHED SENSOR NETWORK NON-LINE-OF-SIGHT DATA TELEMETRY SYSTEM (2007)

A non-line-of-sight digital datalink has been developed and tested using a high frequency radio for transmission of water quality monitoring data within a 20 mile range.Features of this design include real-time continuous monitoring of remote sensor measurements, all-weather 30 Mhz transmission (without repeaters), and solar-powered remote telemetry stations.Remote sensor data is transmitted to a central monitoring station from a network of water quality sensor sites for alarms, analysis, and archiving purposes.The data telemetry system has the potential for receiving water quality monitoring data from several watershed locations simultaneously at one data processing point.Lastly, the cost efficiency of this system compared to typical cellular, satellite, or phone landline datalink systems.
Synthesis and Characterization of Neopentyl Indium Compounds: X-ray Crystal Structures of [(Me3CCH2)2InAs(SiMe3)2]2 and (Me3CCH2)2InAs(SiMe3)2In(CH2CMe3)2Cl (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Characterization of Neopentyl Indium Compounds: X-ray Crystal Structures of [(Me3CCH2)2InAs(SiMe3)2]2 and (Me3CCH2)2InAs(SiMe3)2In(CH2CMe3)2ClLeonidas J. Jones III, Andrew T. McPhail, and Richard L. WellsCite this: Organometallics 1994, 13, 9, 3634–3638Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/om00021a041https://doi.org/10.1021/om00021a041research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts