gebhart/patrepeval huggingface dataset:
Analysis of viral proteins in circulating immune complexes from chronic carriers of hepatitis B virus. (1991)

Sera from 54 children (mean age 5.8 years) with chronic hepatitis B virus (HBV) infection were investigated for the presence of immune complexes containing HBV proteins. Clinical diagnosis was established by histology and biochemical markers and included chronic persistent (36 cases) or chronic aggressive (seven) hepatitis, liver cirrhosis (six) and HBV-mediated membranous glomerulonephritis (five). Circulating immune complexes were precipitated with 2.5% polyethylene glycol and analysed by immune blot using monoclonal antibodies against S, pre-S2 glycopeptide, pre-S1 and HBe/c epitopes. All sera, including those from 11 healthy HBV-negative blood donors contained PEG-precipitable substances, but the amount of precipitate did not correlate with the presence or amount of HBV proteins. The great majority (36 out of 40) of HBeAg-positive patients contained HBs proteins in immune complexes, but no detectable HBe protein. The immune complexes usually contained more pre-S1 than the free HBsAg particles from the same patient. The precipitates of anti-HBe-positive patients rarely contained HBV proteins (two out of 14) and, if so, in low amounts. During follow up of six patients we found that high levels of HBs-containing immune complexes may be correlated with subsequent elimination of HBV. This elimination is possibly initiated by binding of anti-pre-S1 antibodies to HBV and HBs particles.
Diffusion in Al-Ni and Al-NiCr Interfaces at Moderate Temperatures (2010)

The diffusion couples for experimental study were prepared by HVOF spraying of nickel and nickel with 20 wt.% of chromium powders onto an aluminium sheet surface. The interfaces with sharp gradients of chemical concentration of these elements were prepared. Annealing at temperatures of 600°C and 630°C, close to the Al + Al3Ni eutectic melting point (639.9°C), with different dwell times were used. During annealing, the reactants diffuse and form layers of Al3Ni2 and Al3Ni intermediate phase compositions. Moreover, nickel without the assistance of chromium diffuses preferably along the grain boundaries into aluminium substrate and produces the strengthening of the substrate by stable Al3Ni and metastable Al9Ni2 particles. The microstructures were obtained by scanning electron microscopy. Layer thickness measurements were realized by means of image analyses. Chemical composition was estimated by energy dispersive microanalysis measurements. According to the results of the analyses performed the average chemical interdiffusion coefficients and Wagner’s integral interdiffusion coefficients were calculated.
Identification of Substituted 3-[(4,5,6,7-Tetrahydro-1<i>H</i>-indol-2-yl)methylene]- 1,3-dihydroindol-2-ones as Growth Factor Receptor Inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rβ Tyrosine Kinases (2000)

A series of new 3-substituted indolin-2-ones containing a tetrahydroindole moiety was developed as specific inhibitors of receptor tyrosine kinases associated with VEGF-R, FGF-R, and PDGF-R growth factor receptors. These compounds were evaluated for their inhibitory properties toward VEGF-R2 (Flk-1/KDR), FGF-R1, PDGF-Rbeta, p60(c)()(-)()(Src)(), and EGF-R tyrosine kinases and their ability to inhibit growth factor-dependent cell proliferation. Structure-activity relationships of this new pharmacophore have been determined at the level of kinase inhibition. Compounds containing a propionic acid moiety at the C-3' position of the tetrahydroindole ring represented the most potent indolin-2-ones to inactivate the VEGF, FGF, and PDGF receptor kinases. The inhibitory activities of 9d against VEGF-R2 (Flk-1), 9h against FGF-R1, and 9b against PDGF-Rbeta were 4, 80, and 4 nM, respectively. However, all of these compounds were inactive when tested against the EGF-R tyrosine kinase. Compounds 9a and 9b represented the most potent inhibitors of these classes to inhibit both biochemical kinase and growth factor-dependent cell proliferation for these three targets. In addition, compound 9a was cocrystallized with the catalytic domain of FGF-R1 providing evidence to explain the structure-activity relationship results. This study has provided evidence to support the potential of these new tyrosine kinase inhibitors for the treatment of angiogenesis and other growth factor-related diseases including human cancers.
Efficacy of Second-line Targeted Therapy for Renal Cell Carcinoma According to Change from Baseline in International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Category (2016)

The pattern of treatment failure might help to predict what the next treatment should be for patients with metastatic renal cell carcinoma.
An exploratory study on the influence of developers in technical debt (2018)

Software systems are often developed by many developers who have a varying range of skills and habits. These developers have a big impact on software quality. Understanding how different developers and developer characteristics impact the quality of a software is crucial to properly deploy human resources and help managers improve quality outcomes which is essential for software systems success. Addressing this concern, we conduct a study on how different developers and developer characteristics such as developer seniority in a system, frequency of commits, and interval between commits relate to Technical Debt (TD). We performed a large-scale analysis on 19,088 commits from 38 Apache Java systems and applied multiple statistical analysis tests to evaluate our hypotheses. Our empirical evaluation suggests that developers unequally increase and decrease TD, a developer seniority in a software system and frequency of commits are negatively correlated with the TD the developer induces, and a developer commit interval has a positive correlation with the TD the developer induces.
CS-based fall detection for connected health applications (2017)

Fall-related injuries of elderly people have become a major public-health burden resulting in direct physical, physiological and financial costs to the surfer and indirect societal costs. Automated fall detectors play a central role in reducing these damages and in supporting safety and independency of the seniors. Typically, automated fall detection devices can send real time notifications to the caregivers in case of emergency. In this study, we consider the problem of fall detection of compressively sensed data. The proposed approach involves first, acquiring acceleration data from different subjects using different fall and activities of daily living (ADLs) scenarios by means of shimmer devices. The collected data is then, multiplied by a binary sensing matrix. Two classification approaches were investigated using k-nearest neighbour (KNN) and extended nearest neighbour (ENN), respectively. Our experiments showed promising results with accuracies of up to 91.34 % and 91.73 % on the test set using five and ten folds cross validation respectively.
What Makes the Photocatalytic CO<sub>2</sub> Reduction on N-Doped Ta<sub>2</sub>O<sub>5</sub> Efficient: Insights from Nonadiabatic Molecular Dynamics (2015)

Recent experimental studies demonstrated that photocatalytic CO2 reduction by Ru catalysts assembled on N-doped Ta2O5 surface is strongly dependent on the nature of the anchor group with which the Ru complexes are attached to the substrate. We report a comprehensive atomistic analysis of electron transfer dynamics in electroneutral Ru(di-X-bpy) (CO)2Cl2 complexes with X = COOH and PO3H2 attached to the N-Ta2O5 substrate. Nonadiabatic molecular dynamics simulations indicate that the electron transfer is faster in complexes with COOH anchors than in complexes with PO3H2 groups, due to larger nonadiabatic coupling. Quantum coherence counteracts this effect, however, to a small extent. The COOH anchor promotes the transfer with significantly higher frequency modes than PO3H2, due to both lighter atoms (C vs P) and stronger bonds (double vs single). The acceptor state delocalizes onto COOH, but not PO3H2, further favoring electron transfer in the COOH system. At the same time, the COOH anchor is prone to decomposition, in contrast to PO3H2, making the former show smaller turnover numbers in some cases. These theoretical predictions are consistent with recent experimental results, legitimating the proposed mechanism of the electron transfer. We emphasize the role of anchor stability, nonadiabatic coupling, and quantum coherence in determining the overall efficiency of artificial photocatalytic systems.
Adhesion Molecule Mediated Endothelial Cell Injury Elicited by Activated Leukocytes<sup>a</sup> (1994)

To clarify the mechanism of vascular endothelial cell injury induced by activated leukocytes, we examined the effects of antibodies against adhesion molecules on the injury and on the intracellular peroxide level in endothelial cells. Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes. Monoclonal antibodies against CD11a, CD11b and CD18, and ICAM-1, an adhesion molecule in the side of endothelial cells, abolished significantly the endothelial cell injury induced by PMA-stimulated leukocytes. These antibodies affected neither the production of active oxygen species by the leukocytes nor the rate of adhesion of leukocytes to endothelial cells. These data indicated that adhesion through CD11/CD18-ICAM-1 is necessary for leukocytes to induce endothelial cell injury. To investigate the phenomenon that occurred after the specific adhesion, the change in the intracellular peroxide level was measured using fluorescence of 2,7-dichlorofluorescein diacetate. The fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes increased with time up to 15 minutes, although neither PMA alone nor unstimulated leukocytes alone showed such activity at all. The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes. In contrast, CD11c could block neither the cell injury nor the increase in intracellular fluorescence in endothelial cells exposed to PMA-stimulated leukocytes. Thus, the addition of PMA-stimulated leukocytes to an endothelial cell monolayer caused a significant increase in the intracellular peroxide level in the endothelial cells after 15 minutes and severe endothelial cell injury after 5 hours. Both the early increase in peroxide production and late cell lysis were abolished by specific antibodies against CD11a, CD11b, CD18, and ICAM-1, but not CD11c. There seems to be a close relationship between the early and late events. Both events were only partially blocked by catalase (approximately 40%), but almost completely abolished by deferoxamine, a chelator of ferrous ions, suggesting that hydroxyl radicals produced in endothelial cells themselves from xanthine oxidase may injure the cells from their inside. Therefore, the effect of allopurinol, a specific inhibitor of xanthine oxidase, was examined. Pretreatment of endothelial cells with allopurinol caused significant but not complete inhibition (approximately 60%) of both the early and the late events, suggesting that influx of hydrogen peroxide may also be important.(ABSTRACT TRUNCATED AT 400 WORDS)
Mundella, Anthony, [n.y.] June 24 (1800)

paper copy; addressed to Mr Anthony and Mrs. Mary; REDATED to [1879-1885] and moved to Book 8 8/3/10 RDS
The Cyclin-dependent Kinase Family (1991)

Protein kinases and protein phosphatases play crucial roles in the regulation of a wide variety of cellular functions. The activity of protein kinases can be regulated in several different ways, including binding of ligands to a regulatory domain, phosphorylation and dephosphorylation of critical residues, and association with regulatory subunits.
A MODEL OF SWIMMING ECONOMY DURING INCREMENTAL EXERCISE (2001)

The responses of swimming economy (distance stroke-' (DPS) and stroke rate (SR)) to incremental exercise were examined in 20 highly trained competitive swimmers to derive parameter estimates to model swimming economy during incremental exercise. As the swimmer's velocity increased, DPS was first steady at a maximal value, and then decreased linearly beyond a breakpoint. Conversely, we observed a constant linear increase in SR that did not exhibit a breakpoint or steady state. We defined the maximal DPS as DPS max (m' stroke-'),t he breakpoint as DPSthrehold(m' stroke-'),and the linear decrease as DPSd,, (m' stroke-'velocity-').These results were incorporated into a two segment linear fit of the individual responses. The SR response was described by a regression line and was defined as SR,,, (strokes°minˉ1'~velocityˉ1).
Differentiation of colonic metaplasia from adenocarcinoma of urinary bladder (1997)

Colonic metaplasia and primary bladder adenocarcinoma are relatively uncommon entities that can have similar gross clinical appearances. Examples of colonic metaplasia histologically mimicking cancer have only rarely been reported. We retrospectively analyzed 38 cases of cystitis glandularis (18 cases of colonic metaplasia), 12 cases of adenocarcinoma of urinary bladder (two well-differentiated, WDA), and one in situ adenocarcinoma from the surgical pathology files of Johns Hopkins Hospital. Nine patients with colonic metaplasia had widespread lesions. Two showed superficial muscularis propria involvement, mimicking adenocarcinoma; one of these cases had been diagnosed as infiltrating WDA at both an academic center and a community hospital. Dissecting mucin pools were focally seen in four cases of widespread colonic metaplasia, also mimicking cancer. One of the nine cases showed minimal cytological atypia, but no cases showed mitoses or signet ring cells. Distinguishing WDA from colonic metaplasia was the finding in WDA of infiltrative architectural pattern (two of two), extensive muscle invasion (two of two), moderate anaplasia (one of two), mitotic figures (two of two), and extensive mucinous pools (one of two). The diagnosis of adenocarcinoma in situ was based on anaplasia. Clinically, colonic metaplasia may resemble cancer. Histologically, colonic metaplasia may mimic cancer based on extensive involvement of the lamina propria, focal mucinous pools, focal muscularis propria involvement, focal mild cytological atypia, and rare mitoses. Despite overlapping features with colonic metaplasia, the diagnosis of WDA is based on the greater degree and extent of these atypical findings in cancer.
Suicidal Ideation in Outpatients With Chronic Musculoskeletal Pain (2004)

Chronic pain patients who self-reported severe and frequent initial insomnia with concomitant daytime dysfunction and high pain intensity were more likely to report passive suicidal ideation, independent from the effects of depression severity. Future research aimed at determining whether sleep disturbance is a modifiable risk factor for suicidal ideation in chronic pain is warranted.
How to Game Your Sharpe Ratio (2001)

The Sharpe ratio is a commonly used measure of return/risk performance. However, the Sharpe ratio is susceptible to gaming by managers. This article describes a derivative structure that can induce an upward bias in the measurement of the Sharpe ratio. The structure accomplishes this by shifting returns from the highest monthly return each year to the lowest one. This smoothes observed returns-and lowers observed volatility-without significantly altering the annual return. The objective of the article is to demonstrate how adding derivatives can appear to improve risk-adjusted return without actually doing so.
Heat Transfer on Parallel Plate Heat Exchangers in an Oscillatory Flow (2010)

In thermoacoustic devices, an acoustic wave interacts with internal solid structures such as thermoacoustic stacks (regenerators), to either produce acoustic power due to an imposed temperature gradient, or to produce a heat pumping effect by an acoustic excitation. A cold and hot heat exchangers are usually placed on either side of these internal solid structures to enable heat communication between the thermoacoustic devices and their surroundings. Heat exchangers of various geometries have been extensively studied in steady flows and results are available from a collection of published articles and handbooks. However, there is still a lack of data for heat exchangers in an oscillatory flow, because the interaction of oscillatory flow with the solid boundary is governed by complicated fluid flow and heat transfer processes that are not fully understood. This work is a step towards a better understanding of the heat transfer mechanisms in the acoustically induced oscillatory flow within thermoacoustic systems, in particular obtaining the quantitative description of the heat transfer between heat exchangers and the stack. The assembly of a stack and heat exchangers is replaced by a simplified “stack-less” pair of heat exchangers, in order to focus on the generic heat transfer processes rather than the intricacies of practical thermoacoustic systems. The fins of the hot and cold heat exchangers are kept at constant temperatures by virtue of resistive heating and water cooling, respectively. Planar Laser Induced Fluorescence (PLIF) and Particle Image Velocimetry (PIV) are used to obtain the temperature and velocity fields around the fins. The heat flux between the heat exchanger fins and the fluid is analyzed phase-by-phase. The time dependent local heat transfer coefficient is obtained from the temperature gradient in the thermal boundary layer. The measurements are conducted at various levels of acoustic excitation in order to study the correlation between the non-dimensional heat transfer coefficient Nu and the Reynolds number. The effect of the flow behaviour at the end of the plates on the temperature field in the region is also studied. It is hoped that this work could lead to a better understanding of heat transfer on short plates in the acoustically induced oscillatory flows.
LASIK FLAP LOCATION AND ITS EFFECT ON CORNEAL TOPOGRAPHY. (2001)

Sunday, December 9, 2001. Posters: Academy Information, Binocular Vision, Pediatric Optometry, Primary Care, Ocular Disease, Cornea and Contact Lenses: PDF Only
Synthesis, characterization, and sweetness‐suppressing activities of gurmarin analogues missing one disulfide bond (1998)

The sweetness-suppressing polypeptide gurmarin isolated from Gymnema sylvestre consists of 35 amino acid residues and includes three intramolecular disulfide bonds. The roles of the three disulfide bonds were investigated by replacing each with two alanine residues by solid-phase synthesis. Nine analogues of [Ala3,18]gurmarin, [Ala10,23]gurmarin, and [Ala17,33]-gurmarin were obtained. Three analogues had native disulfide bonds, while the other six had non-native disulfide bonds. The three analogues with native disulfide bonds suppressed the response to sucrose, but not those to glucose, fructose, saccharin, or glycine in rats. In contrast, the six analogues with non-native disulfide bonds did not suppress the responses to any of these sweeteners. These results suggest that the native disulfide bonds of gurmarin are necessary for interaction with the receptor protein, and that the sucrose-specific receptor site is present in rats. © 1998 John Wiley & Sons, Inc. Biopoly 46: 65–73, 1998
Multiple Polymorphic Loci for Molecular Typing of Strains of <i>Mycobacterium leprae</i> (2004)

The need for molecular tools for the differentiation of isolates of Mycobacterium leprae, the organism that causes leprosy, is urgent in view of the continuing high levels of new case detection, despite years of aggressive chemotherapy and the consequent reduction in the prevalence of leprosy. The slow onset of leprosy and the reliance on physical examination for detection of disease have restricted the epidemiological tracking necessary to understand and control transmission. Two genetic loci in several isolates of M. leprae have previously been demonstrated to contain variable-number tandem repeats (VNTRs). On the basis of these reports and the availability of the full genome sequence, multiple-locus VNTR analysis for strain typing has been undertaken. A panel of 11 short tandem repeat (STR) loci with repeat units of 1, 2, 3, 6, 12, 18, 21, and 27 bp from four clinical isolates of M. leprae propagated in armadillo hosts were screened by PCR. Fragment length polymorphisms were detected at 9 of the 11 loci by agarose gel electrophoresis. Sequencing of representative DNA products confirmed the presence of VNTRs between isolates. The application of nine new polymorphic STRs in conjunction with automated methods for electrophoresis and size determination allows greater discrimination between isolates of M. leprae and enhances the potential of this technique to track the transmission of leprosy.
Two Chinese families with pulverulent congenital cataracts and deltaG91 CRYBA1 mutations. (2007)

The previously described CRYBA1 mutation deltaG91 was demonstrated in two Chinese families with distinct phenotypes of congenital cataract, suggesting a lack of genotype-phenotype correlation. The findings also raise the possibility that the delta91 mutation arise in a relatively mutation-prone sequence of the CRYBA1 gene.
Single Heteroatom Fine-Tuning of the Emissive Properties in Organoboron Complexes with 7-(Azaheteroaryl)indole Systems (2016)

The application of organoboron compounds as light-absorbing or light-emitting species in areas as relevant as organic electronics or biomedicine has motivated the search for new materials which contribute to the progress of those applications. This article reports the synthesis of four-coordinate boron complexes based on the unexplored 7-(azaheteroaryl)indole ligands. An easy synthetic approach has enabled the fine-tuning of the electronic structure of the organoboron species by modifying a heteroaromatic component in the conjugated system. Furthermore, a comprehensive characterization by X-ray diffraction, absorption and emission spectroscopy, both in solution and in the solid state, cyclic voltammetry, and computational methods has evidenced the utility of this simple strategy. Large Stokes shifts have been achieved in solid thin-films which show a range of emitted light from blue to orange. The synthesized compounds have been used as biocompatible fluorophores in cell bioimaging.