gebhart/patrepeval huggingface dataset:
The Involvement of Human Placental Microsomal Cytochrome P-450 in Aromatization (1974)

The aromatization of androstenedione is inhibited in the presence of aminoglutethimide, diethylaminoethyl-2,2-diphenyl valerate HCl (SKF 525-A), and 10-3m KCN, but not carbon monoxide or metyrapone. The role of cytochrome P-450 in this reaction could not, therefore, be unequivocally established by inhibition studies. However, it was determined that steroid binding to placental microsomal cytochrome P-450 is absolutely specific for aromatase substrates, intermediates, and inhibitors. Moreover, the substrate 19-nortestosterone, aromatization of which is inhibited by CO, is a competitive inhibitor of both the aromatization and cytochrome P-450 binding of androstenedione, and vice versa. These results suggest that a single species of cytochrome P-450 is responsible for the aromatization of both steroids. Furthermore, both 19-hydroxyandrostenedione and 19-oxoandrostenedione also compete with androstenedione and 19-nortestosterone for the same species of cytochrome P-450. This suggests that all three hydroxylation reactions of C19 aromatization as well as the aromatization of 19-nortestosterone are carried out at the same enzyme site. In addition, an antibody raised against porcine hepatic NADPH-cytochome c reductase, which specifically inhibits cytochrome P-450 mediated reactions, is a potent inhibitor of the aromatization of both C19 and C18 estrogen precursors. The extent of inhibition of the CO-sensitive aromatization of C18 substrates by the antibody is similar to that observed for CO-sensitive drug hydroxylations occurring in liver microsomes. On the other hand, inhibition of the aromatization of the non-CO-sensitive substrate, androstenedione, by the antibody was atypical in that a much greater inhibitory effect on aromatization than on cytochrome c reduction was found. The distinct patterns of inhibition of aromatization by the reductase antibody are consistent with the hypothesis that the rate of entry of the first electron into the oxidized P-450 substrate complex may be rate limiting in the aromatization of C19 but not C18 steroids. The difference in the rate of entry of the first electron would be reflected in the extent to which the reduced P-450 substrate complex accumulates during the steady state. Since CO inhibition occurs at the level of the reduced P-450 substrate complex, variation in the steady state concentration of this intermediate could explain the difference in CO sensitivity observed between C19 and C18 substrates.
Cell Volume Distribution Pattern Analysis: A Means of Uterine Cancer Detection (1970)

The use of cell volume distribution pattern analysis as a semiautomated means of uterine cancer detection has been evaluated. The results of a study of 339 patients indicate that cell sizing effectively detects preinvasive lesions of the uterus. Compared with the Papanicolaou smear, cell volume distribution pattern analysis is as sensitive as the conventional technic in detecting invasive squamous-cell carcinoma of the cervix. However, for detection of adenocarcinoma of the endocervix and endometrium, cell sizing appears more than twice as sensitive as the conventional Ayre scrape. It was found that Trichomonas vaginalis under certain conditions acts as an interfering factor. From in vitro studies these conditions were determined and the means of eliminating the organism as a contaminant were considered.
Genetic transformation of tropical nitrogen-fixing forest trees (1992)

Acacia and Casuarina are symbiotic nitrogen-fixing tropical tree species which play a major role in large-scale afforestation programs due to their performing growth on poor soils. Genetic improvement through gene transfert technology is a valuable tool to acccelerate the production of improved tree species: long breeding cycles can be by-passed and beneficial traits such as pathogen resistance can be introduced directly. Transgenic Allocasuarina verticillata were obtained after transformation with the Agrobacterium rhizogenes strains A4 (agropine type) and 2659 (cucumopine type) (Phelep et al., 1991). Shoot regeneration occured spontaneously from roots induced by strain 2659. These transformed plants were propagated at a very high rate of shoot multiplication as described by Cao et al. (1990). Transformation of Casuarina glauca, Acacia mangium and Acacia albida has been recently initiated using wild type A. tumefaciens strain 82139 (Brasileiro et al., 1991). Both Casuarina and Acacia species were found to develop tumors after inoculation with the oncogenic Agrobacterium strain. Coinoculation experiments with 82139 and disarmed A. tumefaciens strains containing binary vectors are in progress. (Texte intégral)
New Methods for Purification and Separation of Purines (1958)

This chapter contains sections titled: Introduction Mercury Derivatives of Purines Determination of Uric Acid by Quantitative Precipitation of Mercuric Urate Deproteinization of Purine-Containing Media, Especially of Plasma Purification of Purine-Containing Solutions by Adsorption on a “Mercury Column” Separation of Basic and Non-basic Purines on Cation Exchangers Detection of Purines on Paper Chromatograms Paper Chromatographic Separation and Analysis of Purines Conclusion
A Horn-Reflector Antenna for Space Communication (1961)

This paper describes the mechanical features of the horn-reflector antenna used for receiving signals reflected from the Project Echo balloon satellite and presents in some detail the electrical characteristics (radiation patterns and gain) measured at a frequency of 2390 mc. Theoretically derived characteristics which agree very well with the measurements are also presented; details of the calculations are given in the appendices.
Design of system-on-a-chip test access architectures using integer linear programming (2002)

Test access is a major problem for system-on-a-chip (SOC) designs. Since embedded cores in an SOC are not directly accessible via chip I/Os, special access mechanisms are required to test them after system integration. An efficient test access architecture should reduce test cost and time-to-market by minimizing test application time. We address several issues related to the design of test access architectures. Even though these design problems are NP-complete, they can be solved exactly using integer linear programming (ILP). As a case study, the ILP models for two hypothetical but representative systems are solved using a public-domain ILP software package.
Chloroquine use improves dengue-related symptoms (2013)

Dengue is the most important arboviral disease in the world. As chloroquine, an antimalarial agent, has shown some antiviral effects, this study evaluated its effect in patients with dengue. A randomised, double-blind study was performed by administering chloroquine or placebo for three days to 129 patients with dengue-related symptoms. Of these patients, 37 were confirmed as having dengue and completed the study; in total, 19 dengue patients received chloroquine and 18 received placebo. There was no significant difference in the duration of the disease or the degree and days of fever. However, 12 patients (63%) with confirmed dengue reported a substantial decrease in pain intensity and a great improvement in their ability to perform daily activities (p = 0.0004) while on the medication and the symptoms returned immediately after these patients stopped taking the medication. The same effect was not observed in patients with diseases other than dengue. Therefore, this study shows that patients with dengue treated with chloroquine had an improvement in their quality of life and were able to resume their daily activities. However, as chloroquine did not alter the duration of the disease or the intensity and days of fever, further studies are necessary to confirm the clinical effects and to assess the side effects of chloroquine in dengue patients.
The effect of ion exchange on the flexural strength of feldspathic porcelains. (1992)

The use of ceramic restorative materials is becoming more widely accepted by the dental profession. Concern over the inherent problems related to failure through the propagation of cracks has led to the development of new reinforced ceramics. Ion exchange is a simple, relatively low-temperature process that can have a substantial effect on the flexural strength of feldspathic dental porcelains. This study would support the use of such a material to reinforce dental ceramic restorations.
Mouse Zp1 Encodes a Zona Pellucida Protein Homologous to Egg Envelope Proteins in Mammals and Fish (1995)

Zp1 encodes one of the three major glycoproteins of the zona pellucida, an extracellular matrix that surrounds growing oocytes, ovulated eggs, and preimplantation embryos. The mouse gene is composed of 12 exons ranging in size from 82 to 364 base pairs and spans 6.5 kilobase pairs on chromosome 19 (2.13 +/- 1.5 centimorgans distal to D19Bir1). The Zp1 exon map is similar to ZPB, a human orthologue, and an E-box (CANNTG), implicated in oocyte-specific gene expression of mouse Zp2 and Zp3, is similarly located upstream of the transcription start site. The single copy Zp1 gene encodes a 623-amino acid protein, the carboxyl-terminal half of which is significantly similar to a corresponding region of mouse ZP2. The conservation of this same region in a fish egg envelope protein suggests that not only has this protein domain been duplicated in mammals but that it has been conserved and used as an egg envelope protein in species that diverged 650 million years ago.
Degaussing of Cylinders Magnetized in Earth's Magnetic Field - a Two-Dimentional Model of Degaussing of Submarine (1998)

Abstract As a prelude of three-dimensional modeling of a submarine, an analysis of degaussing of a two-dimensional magnetic cylinder is presented in this paper. The cylinder is of infinite length and may be of arbitrary cross section. As the first step of determining the degaussing current needed for minimizing the magnetic field of the cylinder, a free surface current is assumed on the cylinder surface. Under the influence of the magnetic field produced by the assumed surface current, the cylinder is magnetized and a magnetization current is induced on its surface. An integral equation is formulated for the unknown magnetization current, with the magnetic field due to the assumed surface current as the forcing function. The integral equation is solved numerically employing the moment method. Then, based on knowledge of the magnetization current, the magnetic field produced by the cylinder is calculated. The magnetic field of the cylinder which is magnetized by the assumed surface current is compared with the field of the same cylinder but magnetized in the earth's magnetic field. The ratio of the magnetic flux density of these two fields is taken as the "scaling" factor for determining the degaussing current needed. Numerical results are presented and discussed. In particular, data for a circular cylinder are compared with the analytical results obtained based on image theory. To illustrate the effectiveness of the degaussing system, the magnetic flux density of a magnetic cylinder after applying the degaussing current on its surface is compared to that without the degaussing current.
Synthesis of pyridazinone‐substituted 1,3,4‐thiadiazoles, ‐1,3,4‐oxadiazoles and ‐1,2,4‐triazoles (2001)

Abstract Several 1‐(1‐aryl‐1,4‐dihydro‐3‐carboxy‐6‐methylpyridazin‐4‐one)‐4‐aryl thio‐semicarbazides and their corresponding oxadiazole, thiadiazole and triazole derivatives were prepared and characterized by their spectral data. The preliminary biological tests showed that some new compounds exhibit good anti‐fungal activity.
The Image of Schools and Teachers in Recent American Fiction for Children and Pre-Adolescents (2001)

See article
Theoretical modelling of nonlinear refraction and two-photon absorption in single-wall carbon nanotube bundles (2001)

The nonlinear refractive index n2 and the two-photon absorption coefficient α2 are calculated for a bundle of diameter-distributed and aligned single-wall carbon nanotubes. The dispersion of the nanotube circumference length is shown to have important effects on the resonant behaviour of both quantities under consideration, giving rise to a strong broadening, intensity decrease, and `red' shift of the position of the positive and negative resonant peaks in the n2(ω) and α2(ω) spectra. It is predicted that a relatively large refractive-index change (~ 1 cm2 GW-1) from a positive to a negative peak value produced by a relatively small variation of pump frequency can be achieved for real samples of carbon nanotubes in the frequency range where they are almost transparent. The results indicate that carbon nanotubes are a promising novel class of nanoscale materials that could be used in practical optical switching applications.
Percolation Approach in Underground Reservoir Modeling (2012)

The spatial distribution of the underground heterogeneities which may be appeared on various scales can affect the flow and transport of fluids (e.g. underground spread of pollution or recovery from hydrocarbon reservoirs). Reservoir modeling is conventionally used to incorporate the effect of uncertainty in the spatial distribution of geological heterogeneities (such as fractures as appeared on various scales as emphasized by Odling et al, 1999) and to assess the reservoir performance parameters such as the reservoir connectivity and conductivity. It needs detail data to make geological model, then upscale it to coarser grid and run flow simulation. Since the natural variability of geological formations extends over many length scales, this approach requires very fine modeling schemes. In addition, the predictions may not be achievable in the early life of reservoirs because of the sparse data. Moreover, in stochastic modeling in order to make a reliable underground prediction or for sensitivity purposes, it is necessary to construct a number of possible reservoir models. The problem with this approach is that it is computationally very expensive and time consuming. Hence, there is a great incentive to produce much simpler physically-based model to predict the underground reservoir performance very quickly.
Wide-angle scanning planar array with quasi-hemispherical-pattern elements (2017)

A compact quasi-hemispherical-pattern antenna, two linear wide-angle scanning arrays, and a planar wide-angle scanning array are proposed. To increase the field-of-view scanning range of arrays, a compact low-profile antenna with a quasi-hemispherical pattern is introduced firstly. When the ground is infinite, the proposed antenna has a quasi-hemispherical pattern, i.e., an approximately uniform radiation in the upper half space. Afterward, two linear arrays arranged along the length and width of the proposed antenna's radiation patch are presented. The main beams of the two arrays with 16 active elements can scan from less than -75° to more than +75°. When the linear array element number is 128, the maximum scanning angle can reach 86°. At last, a planar array with 16 × 16 active elements is proposed. In two special planes, xz plane and yz plane, the main beams of the planar array can scan from less than -77° to more than +77° with a gain fluctuation less than 5 dB and a maximum side lobe level (SLL) less than -10 dB. An excellent wide-angle-scanning performance both in linear and planar arrays can be obtained using the proposed method.
EVALUASI PROGRAM KONVERSI MINYAK TANAH KE LPG (LIQUEFIED PETROLEUM GAS) DI KELURAHAN TEMBALANG, KEC. TEMBALANG, KOTA SEMARANG (2013)

Kerosene to LPG program in Kelurahan Tembalang is a program of the central government. This program is an effort by the government to address the heightened oil prices and depleting the availability. World oil prices are rising, affecting the size of the state budget for it, the government convert kerosene to LPG. In addition, the abundant presence of LPG in Indonesia and has not been used optimally. Kerosene to LPG is intended for the middle class and small kerosene users. The purpose of this study was to evaluate and analyze the conversion program from kerosene to LPG in Kelurahan Tembalang, so it can be seen that the impact occurred, success factors, barriers, and recommendations of the program further. The evaluation program is based on indicators by William N Dunn which include: equity, adequacy, and accuracy and indicators according to a LAN that includes: input, output, outcome, benefits and impacts. In this study, researchers used a snowball sampling technique. Data collection method used is in-depth interview techniques, observation and study documentation. This study suggests that the conversion program from kerosene to LPG in Kelurahan Tembalang has both positive and negative. The positive effect is caused by the public convenience and saving of expenditure, while the negative effects are elderly people who are afraid to use LPG 3 kg. Kerosene to LPG in Kelurahan Tembalang running less successful because most of the middle above the target program and the people are reluctant to use LPG. Inhibiting factor is the lack of monitoring of the government, the state of society with poor conditions, 3 kg LPG price in excess of HET.
The IOMA handbook of logistics and inventory management (2002)

PART I: LOGISTICS MANAGEMENT. Benchmarking Logistics Performance. Distribution. International Logistics. Controlling Logistics Costs. Logistics Management and Strategy. Software and Technology. Warehouse Management. Fifty-Four Tips for Improved Logistics Operations. New Logistics Products, Services, and Ideas. PART II: INVENTORY MANAGEMENT. Inventory Reduction Strategies: Insights from the Pros. Inventory Reduction Strategies: IOMA Readers Report What Works. Inventory Reduction Strategies: Case Studies of Success. Technology / Computers / Software. Purchasing / Supplier Issues/Vendor Managed Inventory. Audits and Physical Inventory / Accuracy. Benchmarks. New Inventory Management Products, Services, and Ideas. Best Inventory Management Tips. PART III: SUPPLY CHAIN MANAGEMENT. Supply Chain Management: Insights from the Pros. Supply Chain Management: IOMA Readers Report What Works. Supply Chain Management: Case Studies of Success. Partnering Techniques and Negotiating. E-Purchasing/E-Supply Chain.
Notiz über die Oxydation von 2.3‐Dimethyl‐chinoxalin mit Selendioxyd (1951)

Abstract Es wird die Darstellung des 3‐Methyl‐chinoxalin‐aldehyds‐(2) und der entsprechenden Carbonsäure beschrieben.
Gold(I) and Brønsted Acid Catalyzed Intramolecular Rearrangements of Vinylidenecyclopropanes (2010)

Spot the difference! Different intramolecular rearrangements of vinylidenecyclopropanes containing a secondary alcohol chain were observed depending on whether the reaction was catalyzed by a gold(I) complex or a Brønsted acid (HOTf; OTf=trifluoromethanesulfonate). The corresponding adducts were obtained in moderate to good yields (see scheme). The scope and limitations of these reactions, as well as plausible mechanisms, have been discussed. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
High-Voltage Spindles detection from EEG signals using recursive synchrosqueezing transform (2019)

International audience
Solving Billion-Scale Knapsack Problems (2020)

Knapsack problems (KPs) are common in industry, but solving KPs is known to be NP-hard and has been tractable only at a relatively small scale. This paper examines KPs in a slightly generalized form and shows that they can be solved nearly optimally at scale via distributed algorithms. The proposed approach can be implemented fairly easily with off-the-shelf distributed computing frameworks (e.g. MPI, Hadoop, Spark). As an example, our implementation leads to one of the most efficient KP solvers known to date – capable to solve KPs at an unprecedented scale (e.g., KPs with 1 billion decision variables and 1 billion constraints can be solved within 1 hour). The system has been deployed to production and called on a daily basis, yielding significant business impacts at Ant Financial.
An intelligent inspection and survey robot (1995)

ARIES (Autonomous Robotic Inspection Experimental System) is a semi-autonomous robotic system intended for use in the automatic inspection of stored containers of low level nuclear waste. The project is being performed by a team under the SCUREF (South Carolina University Research and Education Foundation) comprised of the University of South Carolina, and Clemson University, and their industrial partner Cybermotion Inc., with funding from METC, Morgantown, WV. The ARIES program is unusual in the level of cooperation between the universities and Cybermotion. By maintaining daily communications via telephone and E-Mall, participating in frequent meetings with each other and the end users, and by developing an open flow of (sometimes sensitive) technical information, the team has been able to build on a very broad base of intellectual strengths and existing technology without wasteful duplication. This base includes all of the navigation and control software and hardware developed by Cybermotion over nearly a decade and the deep technology resources of the university partners. It is anticipated that the result will be a technically advanced system that is much closer to a deployable configuration than is typical for this stage of research. In this decade of shrinking budgets, such relationships can provide a crucial advantage for all participants.
Teratologic and reproductive studies of lofexidine. (1982)

2-[1-(2,6-Dichlorphenoxy)-ethyl]-2-imidazoline hydrochloride (lofexidine, Lofetensin and Loxacor) elicited no evidence of teratogenicity when administered orally during the period of organogenesis to pregnant rats at doses up to 3.0 mg/kg/day or to pregnant rabbits at doses up to 15.0 mg/kg/day. In reproductive studies there were no effects on conception or pregnancy in male or female rats at dosages up to 1.0 mg/kg/day or male or female rabbits at dosages up to 1.5 mg/kg/day. Dosages of 1.0 mg/kg/day in rats and 6.4 mg/kg/day in rabbits reduced survival and growth rates of neonates and dosages of 3.0 mg/kg/day in rats and 5.0 mg/kg/day or more in rabbits caused reduced fetal weights and increased postimplantation losses. Since neonatal effects occurred only at dosages which produced clinical signs in the dams (1.0 mg/kg/day in rats and 1.5 mg/kg/day in rabbits which correspond to 100 or 150 times, respectively, the therapeutic dose in man) and since fetal effects occurred only at those dosages which caused some maternal deaths, the adverse fetal and neonatal effects produced by lofexidine were attributed to maternal toxicity rather than a direct effect on the fetus or newborn.