gebhart/patrepeval huggingface dataset:
Virtual diode mixer for wideband mixing applications (1996)

Many wideband applications require diode mixing over several octaves. This often means using separate diode mixing circuits (and associated mechanical and electrical switching networks) which can produce measurement glitches at the crossover frequencies. The authors present the design and measurement of a unique, nine octave virtual mixer design to eliminate the need for RF switches.
ChemInform Abstract: CHEMISTRY OF CEPHALOSPORIN ANTIBIOTICS. 28. PREPARATION AND BIOLOGICAL ACTIVITY OF 3‐(SUBSTITUTED)VINYL CEPHALOSPORINS (1976)

Abstract Aus dem Cephem‐1‐oxid (I) erhält man mit Chromsäure den Aldehyd (II), der nach Wittig mit den‐Yliden (III) zu den Olefinen (IV) kondensiert werden kann.
The Difficulty of Training Deep Architectures and the Effect of Unsupervised Pre-Training (2009)

Whereas theoretical work suggests that deep architectures might be more e cient at representing highly-varying functions, training deep architectures was unsuccessful until the recent advent of algorithms based on unsupervised pretraining. Even though these new algorithms have enabled training deep models, many questions remain as to the nature of this di cult learning problem. Answering these questions is important if learning in deep architectures is to be further improved. We attempt to shed some light on these questions through extensive simulations. The experiments confirm and clarify the advantage of unsupervised pre-training. They demonstrate the robustness of the training procedure with respect to the random initialization, the positive e ect of pre-training in terms of optimization and its role as a regularizer. We empirically show the influence of pre-training with respect to architecture depth, model capacity, and number of training examples.
Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent (2016)

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated inappropriately in a wide range of hematological and solid cancers, but clinically available therapies targeting STAT3 are lacking. Using a computational strategy to identify compounds opposing the gene expression signature of STAT3, we discovered atovaquone (Mepron), an antimicrobial approved by the US Food and Drug Administration, to be a potent STAT3 inhibitor. We show that, at drug concentrations routinely achieved clinically in human plasma, atovaquone inhibits STAT3 phosphorylation, the expression of STAT3 target genes, and the viability of STAT3-dependent hematological cancer cells. These effects were also observed with atovaquone treatment of primary blasts isolated from patients with acute myelogenous leukemia or acute lymphocytic leukemia. Atovaquone is not a kinase inhibitor but instead rapidly and specifically downregulates cell-surface expression of glycoprotein 130, which is required for STAT3 activation in multiple contexts. The administration of oral atovaquone to mice inhibited tumor growth and prolonged survival in a murine model of multiple myeloma. Finally, in patients with acute myelogenous leukemia treated with hematopoietic stem cell transplantation, extended use of atovaquone for <i>Pneumocystis</i> prophylaxis was associated with improved relapse-free survival. These findings establish atovaquone as a novel, clinically accessible STAT3 inhibitor with evidence of anticancer efficacy in both animal models and humans.
Fabrication of InP/GaInAs Double Heterojunction Bipolar Transistors with a 0.1-µm-Wide Emitter (2002)

InP/GaInAs double heterojunction bipolar transistors (DHBTs) with a 0.1-µm-wide emitter along the <010 > direction were fabricated by the self-aligned process. A DC current gain of β=51 as a maximum value was observed. Current amplification was confirmed even when an emitter current was 1 µA. A 0.1-µm-wide emitter was formed by the combination of CH4/H2-reactive ion etching and two kinds of wet etching based on HCl. To our knowledge, this HBT has the narrowest emitter that has ever been reported.
A bioartificial liver used as a bridge to liver transplantation in a 10-year-old boy (1994)

Articles| May 01 1994 A bioartificial liver used as a bridge to liver transplantation in a 10-year-old boy EB LePage; EB LePage Search for other works by this author on: This Site PubMed Google Scholar J Rozga; J Rozga Search for other works by this author on: This Site PubMed Google Scholar P Rosenthal; P Rosenthal Search for other works by this author on: This Site PubMed Google Scholar F Watanabe; F Watanabe Search for other works by this author on: This Site PubMed Google Scholar HC Scott; HC Scott Search for other works by this author on: This Site PubMed Google Scholar AM Talke; AM Talke Search for other works by this author on: This Site PubMed Google Scholar AA Demetriou AA Demetriou Search for other works by this author on: This Site PubMed Google Scholar Am J Crit Care (1994) 3 (3): 224–227. https://doi.org/10.4037/ajcc1994.3.3.224 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Cite Icon Cite Get Permissions Citation EB LePage, J Rozga, P Rosenthal, F Watanabe, HC Scott, AM Talke, AA Demetriou; A bioartificial liver used as a bridge to liver transplantation in a 10-year-old boy. Am J Crit Care 1 May 1994; 3 (3): 224–227. doi: https://doi.org/10.4037/ajcc1994.3.3.224 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Journal of Critical Care Search Advanced Search You do not currently have access to this content.
Aktuelle Epidemiologie des Ösophaguskarzinoms und des Kardiakarzinoms in Deutschland (2002)

In Germany, during the past 15-20 years, the incidence of esophageal AC and presumably also of AC of the cardia has increased. But the incidence of squamous cell carcinoma of the esophagus has remained largely constant. The proportion of early carcinoma and the 5-year survival with esophageal carcinoma remains under 10%.
Human cytomegalovirus as a direct pathogen: Correlation of multiorgan involvement and cell distribution with clinical and pathological findings in a case of congenital inclusion disease (2002)

The human cytomegalovirus (HCMV), a member of the Herpesviridae, is the most frequent cause of congenital virus infections and a major cause of morbidity and mortality in immunocompromised patients. Due to the lack of an appropriate animal model, insight into the pathogenesis of HCMV infections originates primarily from in situ examination of HCMV-infected tissues. Although in immunocompromised adults such tests are complicated frequently by the presence of additional misleading pathogens, the absence of additional pathogens renders congenital inclusion disease the most suitable access for investigation of pathogenetic aspects of HCMV infections. Immunohistochemical examination of tissue sections from a boy with fatal congenital inclusion disease was undertaken to detect the extent of multiorgan and cell involvement. Adrenal gland, bone marrow, diencephalon, heart, kidney, liver, lung, pancreas, placenta, small bowel and spleen were included in this study. Detection of virus antigens from different phases of viral replication revealed that all investigated organs were infected by HCMV. Simultaneous detection of cell type specific marker molecules showed that a variety of cell types stained positive for HCMV antigens including endothelial cells, epithelial cells, smooth muscle cells, mesenchymal cells, hepatocytes, monocytes/macrophages and granulocytes. The lung, the pancreas, the kidneys and the liver were the major target organs with a high number of HCMV infected cells. This correlated with multiorgan failure as the cause of death and strongly indicates direct pathogenetic effects of HCMV.
Extracting New Value from Legacy OBC Data by a Holistic Use of Innovative Depth Imaging Technologies (2014)

Summary Recent improvements in imaging techniques and workflows can derive additional value from existing legacy datasets. This case study from the Gulf of Mexico Shelf illustrates how new techniques in high-resolution earth model building and advanced migration algorithms, complemented by image enhancement, can improve existing seismic images, ultimately adding extra value for further exploration and development. We focus in particular on enhancements arising from well-data-constrained anisotropic model building, high-resolution wide azimuth common-image point tomography with offset-vector tiles in a novel binning scheme, and reverse time migration with vector image partitions combined with image conditioning and enhancement techniques. We clearly demonstrate that reprocessing with optimal use of new technology is the most efficient and cost-effective way to increase the value of available data.
The Effect of the Meniett Device in Patients With Ménière's Disease (2008)

The Meniett device is a minimally invasive, nondestructive treatment that may be used to provide longer-term reduction of vestibular symptoms in patients with Ménière's disease.
Self-Organized Short-Term Memories (1997)

We report short-term memory formation in a nonlinear dynamical system with many degrees of freedom. The system ``remembers'' a sequence of impulses for a transient period, but it coarsens and eventually ``forgets'' nearly all of them. The memory duration increases as the number of degrees of freedom in the system increases. We demonstrate the existence of these transient memories in a laboratory experiment.
The susceptibility to infection by Leishmania panamensis and the sensitivity to drugs differ according to the macrophage type (2010)

Introduction: In vitro systems are useful in the evaluation of compounds with biological activity determining the cytotoxic and leishmanicidal activity of the candidates. Objective: To identify the mammalian cell that allows the optimal in vitro infection by Leishmania and therefore, identify the suitable system for the in vitro evaluation of leishmanicidal activity of drugs. Methodology: The susceptibility to the infection by L. panamensis was evaluated according to the Infective Concentration 50 tested by light microscopy and flow citometry; the intracellular survival of amastigotes was determined by fluorescence microscopy and the sensitivity to amphotericine B and meglumine antimoniate was evaluated by spectrophotometry. Results: The primary culture cells were more susceptible to the in vitro infection by L. panamensis because they did require fewer parasites per cell ratio to achieve the 50% infection rate whereas the intracellular survival of parasites was better in the U-937 cells. All cells showed differential sensitivity to amphotericine B and meglumine antimoniate. Conclusion: The U-937 cells are the most suitable model for the in vitro infection by L. panamensis because: a) they are a cell line with unlimited growth where transformation into macrophages can be induced. b) The susceptibility to infection by L. panamensis is similar to that observed in primary cultures macrophages and, c) They allow the intracellular survival of amastigotes after the infection process. In addition the U-937 cells are less sensitive to the action of the commonly drugs used as a control in the screening of compounds with leishmanicidal activity. Salud UIS 2010; 42: 200-211
Adaptive Q control for Tapping-mode Nano-scanning Using a Piezo-actuated Bimorph Probe (2012)

A new approach, called Adaptive Q-control, for tapping-mode Atomic Force Microscopy (AFM) is introduced and implemented on a home-made AFM set-up utilizing a Laser Doppler Vibrometer (LDV) and a piezo-actuated bimorph probe. In the standard Q-control, the effective Q-factor of the scanning probe is adjusted prior to the scanning depending on the application. However, there is a trade-off in setting the effective Q-factor of an AFM probe. The Q-factor is either increased to reduce the tapping forces or decreased to increase the maximum achievable scan speed. Realizing these two benefits simultaneously using the standard Q-control is not possible. In adaptive Q-control, the Q-factor of the probe is set to an initial value as in standard Q-control, but then modified on the fly during scanning when necessary to achieve this goal. In this paper, we present the basic theory behind the adaptive Q-control, the electronics enabling the on-line modification of the probe's effective Q-factor, and the results of the experiments comparing three different methods: scanning a) without Q-control, b) with the standard Q-control, and c) with the adaptive Q-control. The results show that the performance of the adaptive Q-control is superior to the other two methods.
Epidermolysis bullosa acquisita in childhood - a case mimicking chronic bullous dermatosis of childhood (1997)

Epidermolysis bullosa acquisila (EBA) is rarely reported in childhood, hut we mm describe a 6‐year‐old Korean girl with the condition. She presented with multiple tense bullae annularly distributed on the perioral, periorbital and genital areas, and was successfully treated with dapsoae. The clinical and histological features were similar to those of chronic bullous dermatosis of childhood. We review seven previously reported childhood EBA cases and contrast their features with those of adult EBA. We suggest that some childhood EBA is different from the adult form and shares features with chronic bullous dermatosis of childhood. Epidermolysis bullosa acquisita (EBA) is an acquired, chronic, subepidermal bullous disease,1 characterised by IgG autoantibodies reacting with type VII collagen of the fibrils beneath the basement membrane Zone of the stratified squamous epithelium.2,3 Its clinical and epidemiological features are not fully understood, and only a few cases in children have so far been reported.4–8
A Direct Preparation of 6-Methylene-2-cyclohexenones (2004)

The reaction of enol silyl ethers with Eschenmoser’s salt, followed by methylation and elimination, provides ready access to 6-methylene-2-cyclohexenones.
ASR satisficing: the effects of ASR accuracy on speech retrieval (2000)

We examine how differences in the accuracy of Automatic Speech Recognition transcripts affect users’ ability to use these in tasks requiring the retrieval of speech “documents”. We compare performance measures, processing strategies, and preference data for subjects using transcripts and speech data to perform a series of relevance judgment and summary tasks on transcripts with different levels of accuracy. Results show effects for transcript quality on solution accuracy, time to solution, amount of speech played for the task, likelihood of subjects abandoning use of a transcript, and subject perceptions of task difficulty, transcript utility, readability, and comprehensibility.
Long-term survival with open-chest cardiac massage after ineffective closed-chest compression in a canine preparation. (1987)

The ultimate goal of cardiopulmonary resuscitation (CPR) is long-term, neurologically intact survival. This study examined whether open-chest cardiac massage could improve 7 day survival and neurologic function when instituted after the failure of standard closed-chest compression CPR. Twenty-nine mongrel dogs were anesthetized and then instrumented with catheters to monitor right atrial and ascending aortic pressures. Ventricular fibrillation was induced and after 3 min standard CPR was begun. Standard CPR was performed with a Thumper programmed for 2 inch chest compressions at 60/min with a 50% duty cycle. External defibrillation was attempted twice after 15 min of ventricular fibrillation. Unsuccessfully defibrillated animals were randomly assigned to either an additional 2 min of continued closed-chest compressions, or 2 min of open-chest cardiac massage. All animals underwent a period of advanced cardiac life support and were followed until they were resuscitated or died. Follow-up care, including scoring of neurologic deficit, was performed for 7 days. In dogs receiving open-chest cardiac massage there was significantly more immediate resuscitation success (14/14 vs 5/14; p less than .005), 24 hr survival (12/14 vs 4/14; p less than .005), and 7 day survival (11/14 vs 4/14; p less than .02) than in those receiving continued closed-chest compression. Open-chest cardiac massage significantly improved long-term outcome when instituted after 15 min of ineffective closed-chest compression.
Intracellular Cysteines of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulate Channel Gating (2002)

The cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ATP-binding cassette superfamily, is a cAMP-activated chloride channel. CFTR contains two transmembrane domains (TMDs), two nucleotide-binding domains (NBDs), and a regulatory (R) domain. We found that whole-cell CFTR-dependent Cl- currents in Xenopus laevis oocytes were sensitive to HgCl(2), suggesting that modification of endogenous cysteines alters channel activity. To understand better this phenomenon, site-directed mutagenesis was employed to generate both individual cysteine replacements and a version of the molecule with no cysteines in the hydrophobic sector. Each mutant displayed a forskolin/IBMX-activated Cl(-) conductance similar to wild type, indicating that none of the cysteines located within the TMDs is essential. Subsequent single-channel analysis of inside-out patches excised from HEK293 cells expressing either cysteine-less or wild-type CFTR showed that intracellular application of a membrane impermeant sulphydryl reagent, p-chloromercuribenzosulfonate (PCMBS), significantly reduced open probability without affecting ion selectivity or conductance. The cysteine-less molecule also acquired a voltage-dependent sensitivity to extracellular PCMBS not observed in the wild type, perhaps due to a more flexible conformation that allowed PCMBS access to the intracellular surface. Together, these experiments suggest that endogenous intracellular cysteines, located primarily within the NBDs and/or R domain, influence channel gating.
Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction (2012)

The renin-angiotensin system (RAS) is a hormone system that has been classically known as a blood pressure regulator but is becoming well recognized as a proinflammatory mediator. In many diverse tissues, RAS pathway elements are also produced intrinsically, making it possible for tissues to respond more dynamically to systemic or local cues. While RAS is important for controlling normal inflammatory responses, hyperactivation of the pathway can cause neural dysfunction by inducing accelerated degradation of some neuronal proteins such as synaptophysin and by activating pathological glial responses. Chronic inflammation and oxidative stress are risk factors for high incidence vision-threatening diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. In fact, increasing evidence suggests that RAS inhibition may actually prevent progression of various ocular diseases including uveitis, DR, AMD, and glaucoma. Therefore, RAS inhibition may be a promising therapeutic approach to fine-tune inflammatory responses and to prevent or treat certain ocular and neurodegenerative diseases.
Acute Renal Failure Complicating Submersion in Sea Water (1971)

Acute renal failure is a recognized complication of near-drowning in fresh water and is generally attributed to the combination of hemolysis and hypotension. Hemolysis does not result from aspiration of sea water, and renal failure has not been regarded as a complication of near-drowning in salt water. In the present report two cases of acute and reversible oliguric renal failure followed episodes of submersion in sea water. Hemolysis was not present. We concluded that acute renal failure in both patients represented acute tubular necrosis resulting from a combination of hypoxia and hypotension.
Retroperitoneoscopic Pyelolithotomy via a Posterior Approach for Large Impacted Renal Pelvic Stone (2001)

Retroperitoneal laparoscopic pyelolithotomy via a posterior approach was successful in a patient with a large impacted renal pelvic stone. This procedure is beneficial as an alternative to open surgery for stones that cannot be treated by SWL or intracorporeal lithotripsy. This procedure may also be the initial treatment in selected cases.
Different Signaling Pathways Expressed by Chicken Naïve CD4<sup>+</sup> T Cells, CD4<sup>+</sup> Lymphocytes Activated with Staphylococcal Enterotoxin B, and Those Malignantly Transformed by Marek’s Disease Virus (2008)

Proteomics methods, based on liquid chromatography and tandem mass spectrometry, produce large "shotgun" proteomes that are most appropriately compared not at the level of differentially expressed proteins only but at the more comprehensive level of biological networks and pathways. This is now possible with the emergence of functional annotation databases and tools, databases of canonical pathways and molecular interactions and computational text mining tools. Here, we used shotgun proteomics, and the differential proteomics modeling functionalities available in the Pathwaystudio network modeling program to define the cell physiology of Hodgkin's disease antigen-overexpressing (CD30 (hi)) CD4 (+) T cell lymphomas using the unique Marek's disease (MD) natural animal model. CD30 (hi) lymphoma cells have characteristics of activated T cells but are also fundamentally different from their nontransformed healthy counterparts. We compared the cell physiology of naïve, superantigen-activated and MD-transformed CD4 (+) T cell proteomes. While the superantigen-activated cells had signaling pathways associated with cell activation, inflammation, proliferation and cell death, the MD-transformed cells had growth factor, cytokine, adhesion, and transcription factor signaling responses associated with oncogenicity, cell proliferation, angiogenesis, motility, and metastasis.
Objective quality measures applied to enhanced speech (1985)

Previously reported experiments have indicated that computer enhancement of single channel speech in wideband noise generally does not result in increased intelligibility. Our research goal has been to investigate the effect of such enhancement on speech quality. Our experimental framework employed natural speech degraded by additive white, non-white, and aircraft cockpit noise over a wide range of signal-to-noise ratios (− 15 to 20 dB). An iterative enhancement technique based on a method reported by Lim and Oppenheim, was generalized to allow nonwhite additive noise. Spectral estimates of the noise were made using maximum-likelihood method, maximum-entropy method, Burg's method, periodogram, Bartlett's method, and Pisarenko harmonic decomposition. Quality was estimated using a variety of objective measures which have been shown to correlate well with subjective quality scores resulting from the diagnostic acceptibility measure (DAM). Over a large number of noise conditions the best objective qualities resulted when Bartlett, Burg, and maximum-entropy spectra were used. In general, significant improvements in terms of objective measures were observed when enhancement took place. [Work supported by Lockheed Georgia Company.]