gebhart/patrepeval huggingface dataset:
KPC-Mediated Resistance to Ceftazidime-Avibactam and Collateral Effects in Klebsiella pneumoniae (2021)

Carbapenem-resistant <i>Enterobacterales</i>, such as Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae, represent a major threat to public health due to their rapid spread. Novel drug combinations such as ceftazidime-avibactam (CZA), combining a broad-spectrum cephalosporin along with a broad-spectrum β-lactamase inhibitor, have recently been introduced and have been shown to exhibit excellent activity toward multidrug-resistant KPC-producing <i>Enterobacterales</i> strains. However, CZA-resistant K. pneumoniae isolates are now being increasingly reported, mostly corresponding to producers of KPC variants. In this study, we evaluated <i>in vitro</i> the nature of the mutations in the KPC-2 and KPC-3 β-lactamase sequences (the most frequent KPC-type enzymes) that lead to CZA resistance and the subsequent effects of these mutations on susceptibility to other β-lactam antibiotics. Single-step <i>in vitro</i> selection assays were conducted, resulting in the identification of a series of mutations in the KPC sequence which conferred the ability of those mutated enzymes to confer resistance to CZA. Hence, 16 KPC-2 variants and 10 KPC-3 variants were obtained. Production of the KPC variants in an Escherichia coli recombinant strain resulted in a concomitant increased susceptibility to broad-spectrum cephalosporins and carbapenems, with the exceptions of ceftazidime and piperacillin-tazobactam, compared to wild-type KPC enzymes. Enzymatic assays showed that all of the KPC variants identified exhibited an increased affinity toward ceftazidime and a slightly decreased sensitivity to avibactam, sustaining their impact on CZA resistance. However, their respective carbapenemase activities were concurrently negatively impacted.
A monoclonal antibody recognizing a determinant common to HLA—A3 and All (1982)

Spleen cells from a mouse immunized with an AML cell expressing HLA-A3 produced a hybridoma secreting an anti-HLA-A3, A11 monoclonal antibody, 26D3. By complement-dependent cytotoxicity at dilutions to 1:10(4) the ascites antibody lysed 13/13 A3, 15/15 A11, and 8 other lymphocytes from a panel of 98 donors. The 26 D3 immunoprecipitated a molecule consisting of subunits of 44,000 and 12,000 daltons. Monoclonality of the antibody was demonstrated by isoelectric focusing and protein A affinity chromatography.
Growing p-type 3C-SiC heteroepitaxial layers by Vapour-Liquid-Solid mechanism on 6H-SiC substrate (2010)

The present work reports on the tentative growth of p‐type 3C‐SiC layers deposited by vapour‐liquid‐solid (VLS) mechanism using Si‐Ga and Si‐Ge‐Al melts with different compositions and temperatures. It was found that 3C‐SiC polytype was always recorded when both liquid phases were used. However, from Raman characterizations, only the layers grown from Al‐based melts show evidence of p‐type doping, with pronounced Fano interferences. For the layers grown using Ga‐based melts, the layers are n type due to higher (non intentional) incorporation of nitrogen compared to gallium one. A simple mechanism is proposed to explain these differences.
The Deposition of Contaminants from Deionized Water onto Hydrophobic Silicon Wafers (1991)

The liquid-based deposition of particles onto hydrophobic silicon surfaces was investigated by exposing hydrophobic silicon wafers to sample contaminants in a stirred deionized water bath. Wafers were rendered hydrophobic by exposure to dilute hydrofluoric acid, and a goniometer was employed to monitor wafer contact angles. As has been observed in the past for hydrophilic wafers, the zeta potential recorded for the test particle had a significant impact on the deposition resulting on the hydrophobic silicon surfaces. This suggests that, despite treatment with HF and an overall hydrophobic surface behavior, regions remain on the wafer surface which are ionizable in aqueous solutions. The behavior of the silicon test wafers used in these studies is consistent with the presence of a negative zeta potential at the hydrophobic silicon surface. In contrast to the deposition seen on hydrophilic wafers, however, deposition onto hydrophobic silicon is frequently nonuniform. Additionally, Auger analysis indicates that hydrophobic surfaces show a marked tendency to attract hydrocarbon contaminants from the deionized (DI) water. The rinsing technique employed when rendering wafers hydrophobic was found to have a significant effect on baseline particulate levels, and test results indicate that contamination differences between hydrophobic and hydrophilic wafers may be more strongly related to exposure to gas/liquid interfaces than to differences in the rates of particle deposition in bulk solution.
The tangible video editor (2007)

In this paper we introduce the Tangible Video Editor (TVE), a multi-user, tangible interface for sequencing digital video. We present a new approach to tabletop interaction by using multiple handheld computers embedded in plastic tokens. Drawing from the rich physical experience of tradition film editing techniques we designed the TVE to engage multiple users in a collaborative process and encourage the exploration of narrative ideas. We used active tokens to provide a malleable interface, enabling users to organize the interface components in unspecified ways. Our implementation improves upon common projection-based tabletop interfaces in a number of ways including a design for use beyond dedicated two dimensional spaces and a naturally scaling screen resolution.
Omental Flap Coverage of Gore-Tex Mesh: Infections, Milky Spots, and Abdominal Wall ???Exit Site??? Hernias (2006)

Division of Plastic Surgery, Northwestern Memorial Hospital, 675 North St. Clair Street, Suite 19-250, Chicago, Ill. 60611-4807, [email protected] The following letter was intended as an invited Discussion for the November issue. Because of a mix-up, it did not appear. Our apologies to Dr. Dumanian.
N-Polar III–Nitride Green (540 nm) Light Emitting Diode (2011)

We report the demonstration of a N-polar InGaN based green light emitting diode (LED) grown by N 2 plasma-assisted molecular beam epitaxy (PAMBE). High quality multiple quantum well LEDs with In 0.29 Ga 0.71 N quantum wells were grown at a temperature of 600 °C by applying a new growth model. LED structures exhibited green emission, and electroluminescence measurements on the test structure showed peak emission wavelengths varying from 564.5 to 540 nm. The full width at half-maximum reduced from 74 to 63 nm as the drive current was increased to 180 A/cm 2 . This work is the first demonstration of an N-polar LED with emission in the green wavelength range.
Predicting speech intelligibility based on the modulation spectrum and modulation frequency selectivity (2018)

Speech intelligibility depends on factors related to the auditory processes involved in sound perception as well as on the acoustic properties of the sound entering the ear. A clear understanding of speech perception in complex acoustic conditions remains a challenge. Here, a computational modeling framework is presented that attempts to predict the speech intelligibility obtained by normal-hearing and hearing-impaired listeners in various adverse conditions. The model combines the concept of envelope frequency selectivity in the auditory processing of the sound with a decision metric that is based either on the signal-to-noise envelope power ratio or a correlation measure. The proposed model is able to account for the effects of stationary background noise, reverberation, nonlinear distortions and noise reduction processing on speech intelligibility. However, due to its simplified auditory preprocessing stages, the model fails to account for the consequences of individual hearing loss on intelligibility. To address this, physiologically inspired extensions of the auditory preprocessing in the model are combined with the modulation-frequency selective processing and the back-end processing that have been successful in the conditions tested with normal-hearing listeners. The goal is to disentangle the consequences of different types of hearing deficits on speech intelligibility in a given acoustic scenario.
Optimal checkpointing for secure intermittently-powered IoT devices (2017)

Energy harvesting is a promising solution to power Internet of Things (IoT) devices. Due to the intermittent nature of these energy sources, one cannot guarantee forward progress of program execution. Prior work has advocated for checkpointing the intermediate state to off-chip non-volatile memory (NVM). Encrypting checkpoints addresses the security concern, but significantly increases the checkpointing overheads. In this paper, we propose a new online checkpointing policy that judiciously determines when to checkpoint so as to minimize application time to completion while guaranteeing security. Compared to state-of-the-art checkpointing schemes that do not account for the overheads of encrypted checkpoints we improve execution time up to 1.4 ×.
Determination of palladium by controlled-potential coulometry. New platinum-working-electrode cell for controlled-potential coulometry (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of palladium by controlled-potential coulometry. New platinum-working-electrode cell for controlled-potential coulometryL. P. Rigdon and J. E. HarrarCite this: Anal. Chem. 1974, 46, 6, 696–700Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://pubs.acs.org/doi/10.1021/ac60342a012https://doi.org/10.1021/ac60342a012research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
193 DECREASED GLUCOSE TURNOVER FOLLOWING SHORT-TERM TRAINING (1994)

Dept. of Kinesiology, University of Waterloo, Waterloo, ON, and Kinesiology, McMaster University, Hamilton, ON, Canada.
ARTIFICIAL VAGINA (1953)

THE SURGICAL creation of an artificial vagina still intrigues the medical profession. In the past 135 years, countless and tedious methods have been devised only to be discarded because of the magnitude of the procedure and/or the inability to cope with the serious complications. Dupuytren in 1817, Villaume in 1829, and Amussat in 1832,1made a simple opening between the bladder and rectum but could not satisfactorily maintain its caliber. Eventually, methods and materials for lining the pouch were outlined. Free skin flaps, strips of vaginal mucosa from other patients, intestinal wall from both the small and large bowel, hernial sac lining, guinea-pig intestine, peritoneum, fetal membranes, and, lately, Thiersch grafts have been utilized. Heppner, Gersung, Baldwin, Schubert, Graves, Wharton, Falls, Counsellor, and Frank contributed techniques to this end. While all these methods were initiated by the dissection of the area between the bladder and rectum, their greatest differences
BAS form : Produktförbättring U2Implementering vid MFS-resa 1989 (1989)

Swedlanka Industries, the company the project were carried out for, manufactures a variety of products in rubberized coir such as mattresses, cushions, interior fittings in cars and boats etc. Every product is unique, so a special mould of welded steel plates has to be made for every such product which is a complicated and time-consuming work. Our task was to find a way of making a mould, strong enough to last for 10 samples, in a less complicated way.
Calcium-dependent and calcium-sensitizing pathways in the mature and immature ductus arteriosus (2007)

Studies performed in sheep and baboons have shown that after birth, the normoxic muscle media of ductus arteriosus (DA) becomes profoundly hypoxic as it constricts and undergoes anatomic remodeling. We used isolated fetal lamb DA (pretreated with inhibitors of prostaglandin and nitric oxide production) to determine why the immature DA fails to remain tightly constricted during the hypoxic phase of remodeling. Under normoxic conditions, mature DA constricts to 70% of its maximal active tension (MAT). Half of its normoxic tension is due to Ca(2+) entry through calcium L-channels and store-operated calcium (SOC) channels. The other half is independent of extracellular Ca(2+) and is unaffected by inhibitors of sarcoplasmic reticulum (SR) Ca(2+) release (ryanodine) or reuptake [cyclopiazonic acid (CPA)]. The mature DA relaxes slightly during hypoxia (to 60% MAT) due to decreases in calcium L-channel-mediated Ca(2+) entry. Inhibitors of Rho kinase and tyrosine kinase inhibit both Ca(2+)-dependent and Ca(2+)-independent DA tension. Although Rho kinase activity may increase during gestation, immature DA develop lower tensions than mature DA, primarily because of differences in the way they process Ca(2+). Calcium L-channel expression increases with advancing gestation. Under normoxic conditions, differences in calcium L-channel-mediated Ca(2+) entry account for differences in tension between immature (60% MAT) and mature (70% MAT) DA. Under hypoxic conditions, differences in both calcium L-channel-dependent and calcium L-channel-independent Ca(2+) entry, account for differences in tension between immature (33% MAT) and mature (60% MAT) DA. Stimulation of Ca(2+) entry through reverse-mode Na(+)/Ca(2+) exchange or CPA-induced SOC channel activity constrict the DA and eliminate differences between immature and mature DA during both hypoxia and normoxia.
Cardiorenal and Humoral Properties of a Novel Direct Soluble Guanylate Cyclase Stimulator BAY 41-2272 in Experimental Congestive Heart Failure (2003)

The new sGC stimulator BAY 41-2272 potently unloaded the heart, increased cardiac output, and preserved glomerular filtration rate without activation of the renin-angiotensin-aldosterone system in experimental CHF. These beneficial properties make direct sGC stimulation with BAY 41-2272 a promising new strategy for the treatment of cardiovascular diseases such as CHF.
A User-View Of Services And Network: Formal Specification And Interaction Detection (2005)

We first present some general considerations about the service/feature interaction problem, and why formal specifications wilI really increase the efficiency and reliability of the service creation process. We introduce a formal method for detecting some interaction problems, more precisely high level interactions. This method is based on construction of an abstract model of services and network, as seen by users. This method is also based on the notion of service properties (or policies). A property is a declarative specification of basic requirements of service feature. Then, we present an introduction to the existing formal specification tools to be used for such a method. We give some examples of service properties, debating a first approach for confidentiality, security, or taxation properties. For these examples, feature interactions and how they are detected will be presented.
Abstract P2-01-05: Mammographic microcalcifications and breast cancer tumorigenesis: A radiologic-pathologic analysis (2013)

Abstract Background: Microcalcifications (MCs) are tiny deposits of calcium in breast soft tissue. They serve as key diagnostic radiological features for localization of malignancy. Approximately 30% of early invasive breast cancers have fine, granular MCs detectable on mammography; however, their role in breast cancer tumorigenesis is currently unknown. The purpose of this study was to investigate the relationship between mammographic MCs and breast cancer pathology. Methods: A retrospective chart review was performed for 1015 women treated for breast cancer between 2000-2012 at St. Michael's Hospital. Demographic information (age and menopausal status), tumor pathology (size, histology, grade, nodal status and lymphovascular invasion), hormonal status (ER and PR), HER-2 overexpression and presence of MCs were collected for breast cancer patients. Chi-square tests were performed for categorical variables and t-tests were performed for continuous variables. All tests were two-sided and p-values less than 0.05 were considered statistically significant. Results: A total of 1015 patient charts were included; 78 (7.7%) patients had metastatic carcinoma and were excluded from analysis. About 38.3% (287/1015) of the patients presented with mammographic MCs. Patients were more likely to have MCs if they were HER-2 positive (52.9%) as opposed to being HER-2 negative (33.8%) (p&lt;0.001). There was a significant association between MCs and having heterogeneous breast density (p = 0.031) and having multifocal disease (p = 0.044). Patients with invasive ductal carcinomas (40.9%) were more likely to present with MCs than were patients with other tumor histology (p = 0.001). There was a positive correlation between MCs and tumor grade (p = 0.057), with grade III tumors presenting with the most MCs (41.3%), followed by grade II (39.8%) and grade I (30.7%). There was no significant association between mean age, mean tumor size, ER and PR status with the presence of MCs. Conclusion: This is the largest study analyzing data over a 12 year period, suggesting that the appearance of MCs on mammograms is strongly associated with HER-2 overexpression, invasive ductal carcinoma, heterogeneous breast density and multifocal breast cancers. Since HER-2 is implicated in mediating aggressive tumor growth and metastasis, future studies should investigate the molecular pathways connecting HER-2 overexpression and MC development. This would help better understand the role of MCs in breast cancer tumorigenesis. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-01-05.
Dialkylaluminiumhydride als sterisch spezifische Reduktionsmittel für Acetylene (1956)

Abstract Zweifach substituierte Acetylene werden durch Addition von Dialkylaluminiumhydriden bei nachfolgender Zersetzung mit Wasser glatt zu einheitlichen cis ‐Olefinen reduziert.
Thermovibrational instability in supercritical fluids under weightlessness (2008)

Low amplitude, high frequency vibrations can induce in fluids under weightlessness behaviors that resemble those induced by gravity. Supercritical fluids (above their gas-liquid critical point) are used in the space industry and also display universal behavior. They are particularly sensitive to gravity effects. When submitted to vibration (typically 0.1 to 0.5mm amplitude, 10 to 50Hz frequency), a Rayleigh-Bénard-like instability is observed in experiments with H2 and CO2 under weightlessness. The thermal boundary layer created during a temperature change displays periodic fingering perpendicular to the vibration direction. A systematic two-dimensional numerical study by the finite volume method is performed in CO2 that shows that the fingering pattern is due to a thermovibrational instability, characterized by a vibrational Rayleigh number. The simulation and a simplified dimensional analysis show that the fingering wavelength and the vibrational Rayleigh number decrease as a power law with the distance in temperature to the critical point. However, due to the oversimplification of the analysis, the exponent in the simulation is found to be somewhat different than in the theoretical approach, calling for a more complete investigation of the problem.
RXTE Observations of LMC X-1 and LMC X-3 (1998)

Of all known persistent stellar-mass black hole candidates, only LMC X-1 and LMC X-3 consistently show spectra that are dominated by a soft, thermal component. We present results from long (170ksec) Rossi X-ray Timing Explorer (RXTE) observations of LMC X-1 and LMC X-3 made in 1996 December. The spectra can be described by a multicolor disk blackbody plus an additional high-energy power-law. Even though the spectra are very soft (Gamma is about 2.5), RXTE detected a significant signal from LMC X-3 up to energies of 50keV, the hardest energy at which the object was ever detected. Focusing on LMC X-3, we present results from the first year of an ongoing monitoring campaign with RXTE which started in 1997 January. We show that the appearance of the object changes considerably over its ~200d long cycle. This variability can either be explained by periodic changes in the mass transfer rate or by a precessing accretion disk analogous to Her X-1.
Gamma-glutamyl transpeptidase-dependent iron reduction and LDL oxidation--a potential mechanism in atherosclerosis. (1999)

Biochemical and histochemical correlates indicate that gamma-GT can promote LDL oxidation by hydrolyzing GSH into more potent iron reductants. These findings may provide mechanistic clues to the epidemiologic evidence for a possible correlation between persistent elevation of gamma-GT and the risk of fatal reinfarction in patients with ischemic heart disease.
Two-dimensional code acquisition in time and angular domains (2001)

The extension of conventional delay-domain code acquisition to the angular domain is explored. The uncertainty region is partitioned into a number of delay and angular cells. In single-path channels where the interference is modeled as temporarily and spatially white, there exists an optimum number of angular cells minimizing the mean acquisition time. Mean acquisition times up to three times shorter can be attained with the two-dimensional approach. A rather similar behavior is in general found in Lth-order equal amplitude multipath channels, where paths are contiguous in the delay or angular domains. The strategy employed to search through the uncertainty region may have a considerable impact on acquisition performance. The results reveal that the search should proceed not in the direction of the multipath spread but in the other available domain. Proper selection of the search strategy can reduce the synchronization time by a factor of up to two. Two-dimensional code acquisition in scenarios with spatially nonuniform interference is also investigated. In general, the acquisition performance is degraded by the presence of nonuniform interference in the angular domain.
Natural Product Inhibitors of Acetylcholinesterase (2006)

Various natural products, such as physostigmine, have long been recognized as inhibitors of the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the treatment of Alzheimers disease by the blockage of acetylcholine degradation, attempts to find other inhibitors of the enzyme have multiplied, leading to promising candidates such as huperzine A. In this review, a listing is presented of natural product inhibitors, both alkaloid and nonalkaloid in origin. These have been isolated from plant, animal and microbial sources. Details of current testing methods on cholinesterases are given, including solution assays and screening techniques by TLC and HPLC. Keywords: TLC Assays, HPLC Assay, Radiometric Method, AChE activity, Physostigmine, Huperzine A, Amaryllidaceae, Xanthone inhibitors