gebhart/patrepeval huggingface dataset:
The membrane-bound bifunctional peptidylglycine alpha-amidating monooxygenase protein. Exploration of its domain structure through limited proteolysis. (1991)

The biosynthesis of alpha-amidated peptides from their glycine-extended precursors is catalyzed by the sequential action of peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). The two enzymes are part of a bifunctional, integral membrane protein precursor, peptidylglycine alpha-amidating monooxygenase (PAM). The major forms of PAM mRNA in the adult rat atrium differ by the presence or absence of optional exon A, a 315-nucleotide segment separating the PHM and PAL domains. Using antipeptide antibodies specific to the PHM, exon A, PAL, and cytoplasmic domains of rat PAM, carbonate-washed atrial membranes were found to contain proteins corresponding to rPAM-1 and rPAM-2. Digestion of atrial membranes with a variety of endoproteinases released PHM and PAL catalytic activities. Dose-response curves indicated that both catalytic activities were extremely resistant to inactivation by trypsin. Endoproteolytic digestion of atrial membranes with trypsin, chymotrypsin, elastase, thermolysin, or endoproteinase Lys-C generated a 35-kDa PHM fragment. Digestion with trypsin, elastase, thermolysin, or endoproteinase Lys-C generated a 42-kDa PAL fragment. In contrast to the stability exhibited by the PHM and PAL domains, the cytoplasmic domain of PAM was destroyed by most of the enzymes; only digestion with endoproteinase Lys-C generated a stable fragment. Digestion with endoproteinase Arg-C removed the carboxyl-terminal tail from PAM but failed to release the PHM or PAL domains from the membranes. The PHM fragments generated by some of the endoproteinases showed a tendency to adhere to the membranes. Thus the bifunctional PAM protein consists of independent catalytic domains separated from each other and from the putative transmembrane domain by flexible regions accessible to attack by a wide variety of endoproteinases.
Bromocriptine and norethisterone in the treatment of premenstrual syndrome. (1982)

Thirty-six women suffering from premenstrual syndrome were treated with bromocriptine or norethisterone in a randomized placebo-controlled double-blind study. Bromocriptine decreased breast engorgement and irritability (P less than .01) and also decreased the total score of all symptoms (P less than .05). Weight gain during the luteal phase was smaller (P less than .05) during bromocriptine than during placebo treatment. Norethisterone treatment alleviated (P less than .05) breast tenderness. Changes in hormonal parameters and liver function tests during bromocriptine treatment were minimal, whereas norethisterone decreased serum levels of luteinizing hormone (P less than .01), follicle-stimulating hormone (P less than .001), and progesterone (P less than .05), while increasing the serum level of prolactin (P less than .01) and gamma-glutamyltranspeptidase activity (P less than .05). Serum levels of cholic acid and chenodeoxycholic acid remained unchanged during both therapies. Bromocriptine treatment brought about side effects in 6 and norethisterone in 3 women. At the doses used, bromocriptine appears more efficient than norethisterone with regard to premenstrual symptoms, although norethisterone is better tolerated.
Proton electron double resonance imaging (PEDRI) of the isolated beating rat heart (2003)

Proton electron double resonance imaging (PEDRI) is a double resonance technique where proton MRI is performed with irradiation of a paramagnetic solute. A low-field PEDRI system was developed at 20.1 mT suitable for imaging free radicals in biological samples. With a new small dual resonator, PEDRI was applied to image nitroxide free radicals in isolated beating rat hearts. Experiments with phantoms showed maximum image enhancement factors (IEF) of 42 or 28 with TEMPONE radical concentrations of 2-3 mM at EPR irradiation powers of 12W or 6W, respectively. In the latter case, image resolution better than 0.5 mm and radical sensitivity of 5 microM was obtained. For isolated heart studies, EPR irradiation power of 6W provided optimal compromise of modest sample heating with good SNR. Only a small increase in temperature of about 1 degrees C was observed, while cardiac function remained within 10% of control values. With infusion of 3 mM TEMPONE an IEF of 15 was observed enabling 2D or 3D images to be obtained in 27 sec or 4.5 min, respectively. These images visualized the change in radical distribution within the heart during infusion and clearance. Thus, PEDRI enables rapid and high-quality imaging of free radical uptake and clearance in perfused hearts and provides a useful technique for studying cardiac radical metabolism.
An exergy analysis of aluminum casting processes (2009)

environment and economy must both be sustained, and uncontrolled consumption and emission from individual systems cannot be allowed, although problems cannot be solved simply by optimization, sizing down, or combination of the two. It is normal for individual and group to be in conflict, and a manufacturing system that seems to consume only small amount may have underlying system of large consumption and emission, and the load may increase in total sum. To reduce consumption and emission as total while maintaining competitive edge, it is necessary to know the process of consumption and emission that originates from individual and spreads out to entirety, to clarify its size and significance, and to strategically utilize this knowledge. In this paper, we decided to consider exergy as main concept for both evaluation and development. Exergy is Gibbs free energy based on environment, and is defined as maximum work that can be achieved until system and environment reach thermal equilibrium .
Imaging of Transient Structures Using Nanosecond in Situ TEM (2008)

The microstructure and properties of a material depend on dynamic processes such as defect motion, nucleation and growth, and phase transitions. Transmission electron microscopy (TEM) can spatially resolve these nanoscale phenomena but lacks the time resolution for direct observation. We used a photoemitted electron pulse to probe dynamic events with "snapshot" diffraction and imaging at 15-nanosecond resolution inside of a dynamic TEM. With the use of this capability, the moving reaction front of reactive nanolaminates is observed in situ. Time-resolved images and diffraction show a transient cellular morphology in a dynamically mixing, self-propagating reaction front, revealing brief phase separation during cooling, and thus provide insights into the mechanisms driving the self-propagating high-temperature synthesis.
MISAT: Designing a Series of Powerful Small Satellites Based upon Micro Systems Technology (2007)

MISAT is a research and development cluster which will create a small satellite platform based on Micro Systems Technology (MST) aiming at innovative space as well as terrestrial applications. MISAT is part of the Dutch MicroNed program which has established a microsystems infrastructure to fully exploit the MST knowledge chain involving public and industrial partners alike. The cluster covers MST-related developments for the spacecraft bus and payload, as well as the satellite architecture. Particular emphasis is given to distributed systems in space to fully exploit the potential of miniaturization for future mission concepts. Examples of current developments are wireless sensor and actuator networks with plug and play characteristics, autonomous digital Sun sensors, re-configurable radio front ends with minimum power consumption, or micro-machined electrostatic accelerometer and gradiometer system for scientific research in fundamental physics as well as geophysics. As a result of MISAT, a first nano-satellite will be launched in 2007 to demonstrate the next generation of Sun sensors, power subsystems and satellite architecture technology. Rapid access to in-orbit technology demonstration and verification will be provided by a series of small satellites. This will include a formation flying mission, which will increasingly rely on MISAT technology to improve functionality and reduce size, mass and power for advanced technology demonstration and novel scientific applications.
A novel suturing approach for tissue displacement within minimally invasive periodontal plastic surgery (2016)

This paper describes a novel suturing approach that achieves harmonious and atraumatic soft tissue displacement in periodontal plastic surgery and soft tissue management around implants. The technique relies on a combination of horizontal and vertical mattress that are anchored at the splinted incisal contact points.
The GPR early-time method to measure water content of clay soils (2016)

Ground-penetrating radar (GPR) early-time amplitude analysis has recently been proposed as an alternative way for measuring soil water content (SWC) in the shallow subsurface. The method uses amplitude attributes of overlapping GPR air-and ground-waves of bi-static antennas, which have been shown to vary with soil dielectric properties. We tested the feasibility of this approach to characterize soil water content at clay-rich sites. An irrigation experiment was conducted in a natural grassland at the Samford Ecological Research Facility in Queensland, Australia. We collected daily GPR and timedomain reflectometry (TDR) datasets over a five-day period and collected samples for gravimetric moisture analysis. The GPR data display a clear response of the early-time signal amplitude to spatial and temporal changes in SWC. Our results show that the early-time methodology can successfully characterize soil water content at clay-rich sites, where (due to high signal attenuation) traditional GPR methods typically fail.
Sulforaphane decreases kidney injury after transplantation in rats: role of mitochondrial damage (2013)

SFN ameliorates ischemia/reperfusion injury after KTx, most likely through anti-oxidative effects.
Construction of a reference linkage map of Vitis amurensis and genetic mapping of Rpv8, a locus conferring resistance to grapevine downy mildew (2011)

Construction of a reference linkage map of Vitis amurensis and genetic mapping of Rpv8, a locus conferring resistance to grapevine downy mildew. Ecole chercheurs "Génomique et Diversité des Caractères à déterminisme complexe"
Measurements of the critical angle for channeling of heavy ions in copper using characteristic X-ray generation (1972)

Abstract Measurements are presented of ψ1/2, the width of the dip in the yield of CuL X-rays when Ne+, Ar+, Kr+ and Xe+ of 150–350 keV are channeled in the <110> axis of copper. Absorption of the X-rays and the slowing down of the beam are shown to limit the depth from which the detected X-rays can come. The magnitude of the effect of multiple scattering on the measured values of ψ1/2 is shown to be small for all the projectiles except nech. The data has a dependence on (Z 1/E) which is intermediate between that of the critical angles ψ1 and ψ2. A numerical calculation of critical angle gives good agreement with the data. At low energy the calculation uses a potential which is a sum of screened Coulomb and Born-Mayer terms; at higher energy screened Coulomb alone is adequate. A simple analytical expression for the critical angle, based on a 1/r2 atomic potential, may be used as an approximation to the results.
BIOLOGICAL ACTIVITY OF THE PURE THYMUS PROTEIN, LSHr (1979)

<p>Andreas Petrossiants speaks with Marina Vishmidt about her book, <em>Speculation as a Mode of Production: Forms of Value Subjectivity in Art and</em> <em>Capital</em>.</p>\n
Endomorphisms of Banach algebras of infinitely differentiable functions (1998)

In this note we study the endomorphisms of certain Banach algebras of infinitely differentiable functions on compact plane sets, associated with weight sequences M. These algebras were originally studied by Dales, Davie and McClure. \nIn a previous paper this problem was solved in the case of the unit interval for many weights M. Here we investigate the extent to which the methods used previously apply to general compact plane sets, and introduce some new methods. In particular, we obtain many results for the case of the closed unit disc. \nThis research was supported by EPSRC grant GR/M31132
Thermal Processing (2011)

This chapter contains sections titled: Introduction Reaction Kinetics Temperature Dependence Heat Processing Methods Special Problems with Viscous and Particulate Products Ohmic Heating Filling Procedures Storage References
Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling (2015)

SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic chromosome architecture. Both are involved in interphase genome organization. SMC-containing complexes are large (more than 650 kDa for condensin) and contain long anti-parallel coiled-coils. They are thus difficult subjects for conventional crystallographic and electron cryomicroscopic studies. Here, we have used amino acid-selective cross-linking and mass spectrometry combined with structure prediction to develop a full-length molecular draft three-dimensional structure of the SMC2/SMC4 dimeric backbone of chicken condensin. We assembled homology-based molecular models of the globular heads and hinges with the lengthy coiled-coils modelled in fragments, using numerous high-confidence cross-links and accounting for potential irregularities. Our experiments reveal that isolated condensin complexes can exist with their coiled-coil segments closely apposed to one another along their lengths and define the relative spatial alignment of the two anti-parallel coils. The centres of the coiled-coils can also approach one another closely in situ in mitotic chromosomes. In addition to revealing structural information, our cross-linking data suggest that both H2A and H4 may have roles in condensin interactions with chromatin.
CORRIGENDUM TO 'CHARACTERISATION OF A MOBILISABLE PLASMID CONFERRING FLORFENICOL AND CHLORAMPHENICOL RESISTANCE IN ACTINOBACILLUS PLEUROPNEUMONIAE' [VOL 178, PG 279, 2015] (2015)

Decidualisation of the endometrium is a key event in early pregnancy, which enables embryo implantation. Importantly, the molecular processes impairing decidualisation in obese mothers are yet to be characterised. We hypothesise that impaired decidualisation in obese mice is mediated by the upregulation of leptin modulators, the suppressor of cytokine signalling 3 (SOCS3) and the protein tyrosine phosphatase non-receptor type 2 (PTPN2), together with the disruption of progesterone (P4)-signal transducer and activator of transcription (STAT3) signalling. After feeding mice with chow diet (CD) or high-fat diet (HFD) for 16 weeks, we confirmed the downregulation of P4 and oestradiol (E2) steroid receptors in decidua from embryonic day (E) 6.5 and decreased proliferation of stromal cells from HFD. In vitro decidualised mouse endometrial stromal cells (MESCs) and E6.5 deciduas from the HFD showed decreased expression of decidualisation markers, followed by the upregulation of SOCS3 and PTPN2 and decreased phosphorylation of STAT3. In vivo and in vitro leptin treatment of mice and MESCs mimicked the results observed in the obese model. The downregulation of Socs3 and Ptpn2 after siRNA transfection of MESCs from HFD mice restored the expression level of decidualisation markers. Finally, DIO mice placentas from E18.5 showed decreased labyrinth development and vascularisation and fetal growth restricted embryos. The present study revealed major defects in decidualisation in obese mice, characterised by altered uterine response to E2 and P4 steroid signalling. Importantly, altered hormonal response was associated with increased expression of leptin signalling modulators SOCS3 and PTPN2. Elevated levels of SOCS3 and PTPN2 were shown to molecularly affect decidualisation in obese mice, potentially disrupting the STAT3-PR regulatory molecular hub.
434 MHz ISM band antenna for in-body biotelemetry capsules (2017)

We propose a versatile 434 MHz in-body capsule antenna suitable for ingestible and variety of implantable applications. The low profile conformal antenna is synthesized using a hybrid analytical-numerical approach and optimized for robust operation at 434 MHz inside a 17 mm long biocompatible encapsulation (7 mm diameter). The antenna remains matched below -10 dB in wide range of body tissues (from 42% of muscle electromagnetic properties up to the maximum tissue electromagnetic properties). A realized gain is -22.4 dBi and radiation efficiency reaches 0.4%. The radiation performance of the proposed antenna exceeds most of counterparts whereas its impedance characteristics are more robust.
Backscatter‐to‐Extinction Ratio (2004)

This chapter contains sections titled: Exploration of the Backscatter-to-Extinction Ratios: Brief Review Influence of Uncertainty in the Backscatter-to-Extinction Ratio on the Inversion Result Problem of a Range-Dependent Backscatter-to-Extinction Ratio
<title>Calculation of background clutter in infrared imagery: a semiempirical study</title> (1993)

The authors report the statistical analysis of infrared scenes containing a military ground vehicle. The purpose is to attempt to determine the important variables in clutter as well as the robustness of the present definition of clutter through computer simulation. Both variance based and texture based clutter metrics are compared. The authors analyzed both cluttered and non-cluttered scenes.
Salivary gland disorders and diseases: diagnosis and management (2013)

Overall, the text is easy to read and a valuable resource for any head and neck surgeon who desires greater insight into one of the most fascinating glands in the human body. -- M. Boyd Gillespie, MD, Laryngoscope , August, 2012 Salivary glands are unique because of the manifold subtypes of benign and malignant diseases found there. Written by world-renowned experts, Salivary Gland Disorders and Diseases: Diagnosis and Management fills a major gap in the literature by presenting modern and up-to-date knowledge on all aspects of this important field. From new findings at the molecular level, to diagnostic advances in cytopathology, histopathology, biochemistry, and imaging studies, to technical innovations and surgical and medical management, the book covers every diagnostic and therapeutic development and innovation. Its clear, concise, and heavily illustrated approach makes it ideal for use by both beginners and more experienced surgeons and physicians. Features: * Covers the full spectrum of infectious, inflammatory, acute, chronic, benign, and malignant disorders and diseases of the salivary glands * Offers a wealth of expert tips, tricks, pitfalls, and recommendations for effective diagnostic, surgical, and medical management * Highlights all topics with hundreds of full-color images, diagrams, and superbly detailed surgical illustrations As the comprehensive reference in the field, this book is essential for head and neck surgeons, otorhinolaryngologists, maxillofacial surgeons, dentists, oral pathologists, plastic surgeons, and any other clinicians involved in daily clinical management of patients with salivary gland disorders and diseases.
Combining chemical flocculation and bacterial co‐culture of <i>Cupriavidus taiwanensis</i> and <i>Ureibacillus thermosphaericus</i> to detoxify a hardwood hemicelluloses hydrolysate and enable acetone–butanol–ethanol fermentation leading to butanol (2018)

Butanol, a fuel with better characteristics than ethanol, can be produced via acetone-butanol-ethanol (ABE) fermentation using lignocellulosic biomass as a carbon source. However, many inhibitors present in the hydrolysate limit the yield of the fermentation process. In this work, a detoxification technology combining flocculation and biodetoxification within a bacterial co-culture composed of Ureibacillus thermosphaericus and Cupriavidus taiwanensis is presented for the first time. Co-culture-based strategies to detoxify filtered and unfiltered hydrolysates have been investigated. The best results of detoxification were obtained for a two-step approach combining flocculation to biodetoxification. This sequential process led to a final phenolic compounds concentration of 1.4 g/L, a value close to the minimum inhibitory level observed for flocculated hydrolysate (1.1 g/L). The generated hydrolysate was then fermented with Clostridium acetobutylicum ATCC 824 for 120 h. A final butanol production of 8 g/L was obtained, although the detoxified hydrolysate was diluted to reach 0.3 g/L of phenolics to ensure noninhibitory conditions. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 35: e2753, 2019.
[1,1′-Binaphthalen]-2-ol ,3″-[(<i>1</i><i>R</i>,<i>2</i><i>R</i>)-1,2-cyclohexanediylbis(nitrilomethylidyne)]bis[2′-phenyl-, (<i>1</i><i>R</i>,<i>1</i>″<i>R</i>)- (9CI) (2014)

[244781-88-2] C60H46N2O2 (MW 826.01)

InChI = 1S/C60H46N2O2/c63-59-45(35-43-23-9-13-27-49(43)57(59)55-47-25-11-7-21-41(47)31-33-51(55)39-17-3-1-4-18-39)37-61-53-29-15-16-30-54(53)62-38-46-36-44-24-10-14-28-50(44)58(60(46)64)56-48-26-12-8-22-42(48)32-34-52(56)40-19-5-2-6-20-40/h1-14,17-28,31-38,53-54,63-64H,15-16,29-30H2/b61-37+,62-38+/t53-,54-/m1/s1

InChIKey = VKDICYJIXAXPRX-JPFNADMXSA-N





[1,1′-Binaphthalen]-2-ol, 3,3″-[(1R,2R)-1,2-cyclohexanediylbis[(E)-nitrilomethylidyne]]bis[2′-phenyl-, (1S,1″S)- (9CI)



[793694-48-1] C60H46N2O2 (MW 826.01)



[1,1′-Binaphthalen]-2-ol, 3,3″-[(1R,2R)-1,2-cyclohexanediylbis[(E)-nitrilomethylidyne]]bis[2′-phenyl-, (1R,1″R)-



[760971-31-1] C60H46N2O2 (MW 826.01)



[1,1′-Binaphthalen]-2-ol, 3,3″-[(1S,2S)-1,2-cyclohexanediylbis[(E)-nitrilomethylidyne]]bis[2′-phenyl-, (1R,1″R)-



[760971-29-7] C60H46N2O2 (MW 826.01)



[1,1′-Binaphthalen]-2-ol, 3,3″-[(1R,2R)-1,2-cyclohexanediylbis(nitrilomethylidyne)]bis[2′-phenyl-, (1S,1″S)-



[618380-83-9] C60H46N2O2 (MW 826.01)



[1,1′-Binaphthalen]-2-ol, 3,3′-[(1S,2S)-1,2-cyclohexanediylbis(nitrilomethylidyne)]bis[2′-phenyl-, (1R,1″R)-.



[368454-69-7] C60H46N2O2 (MW 826.01)



(chiral salen ligand for enantioselective transition metal-catalyzed reactions, including Ru-, Co-, and Ir- catalyzed cyclopropanation of alkenes,1 Ti-catalyzed sulfoxidation and Ru-catalyzed sulfimidation of sulfides,2 Mn-, Ru-, and Nb- catalyzed epoxidation of alkenes,3 Ir- and Mn- catalyzed CH bond functionalization,4 Ru-catalyzed oxidative kinetic resolution of sec-alcohols,5 and Zr- catalyzed asymmetric Baeyer–Villiger oxidations6)



Solubility: soluble in common organic solvents.



Preparative Methods: the chiral salen ligand 1 can be rapidly prepared in excellent yield by condensation of (1R, 2R)-1,2-cyclohexanediamine with (R)-3-formyl-2-hydroxy-2′-phenyl-1,1′-binaphthyl 27 in EtOH under an inert atmosphere at ambient temperature for 6 h (eq 1).1b

(1)



Preparation of optically active metal salen–1 complexes, M(salen), is generally achieved by simply mixing a solution of ligand 1 with an appropriate metal salt at elevated temperature.



Handling, Storage, and Precautions: toxicity unknown; use in a fume hood, handle with appropriate safety protection equipment.