gebhart/patrepeval huggingface dataset:
Performance Evaluation for Motif-Based Patterned Texture Defect Detection (2008)

This paper carries an extensive evaluation on the performance of a generalized motif-based method for detecting defects in 16 out of 17 wallpaper groups in 2-D patterned texture. The motif-based method evolves from the concept that every wallpaper group is defined by a lattice, which contains a further constituent-motif. It utilizes the symmetry properties of motifs to calculate the energy of moving subtraction and its variance among motifs. Decision boundaries are determined by learning the distribution of those values among the defect-free and defective patterns in the energy-variance space. In this paper, shape transform for irregular motif has been demonstrated according to the three basic motif shapes: rectangle, triangle, and parallelogram. An error analysis for the misclassifications has also been delivered. In the database of fabrics and other patterned textures, a total of 381 defect-free lattices are used for formulation of boundaries while further 340 defect-free and 233 defective lattices are for testing. The motif-based method has a consistent result and reaches a detection success rate of 93.86%.
Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease (2001)

Mutations in the mitochondrial DNA (mtDNA) can cause a variety of human diseases. In most cases, such mutations are heteroplasmic (i.e. mutated and wild-type mtDNA coexist) and a small percentage of wild-type sequences can have a strong protective effect against a metabolic defect. Because a genetic approach to correct mtDNA mutations is not currently available, the ability to modulate heteroplasmy would have a major impact in the phenotype of many patients with mitochondrial disorders. We show here that a restriction endonuclease targeted to mitochondria has this ability. A mitochondrially targeted PstI degraded mtDNA harboring PstI sites, in some cases leading to a complete loss of mitochondrial genomes. Recombination between DNA ends released by PstI was not observed. When expressed in a heteroplasmic rodent cell line, containing one mtDNA haplotype with two sites for PstI and another haplotype having none, the mitochondrial PstI caused a significant shift in heteroplasmy, with an accumulation of the mtDNA haplotype lacking PstI sites. These experiments provide proof of the principle that restriction endonucleases are feasible tools for genetic therapy of a sub-group of mitochondrial disorders. Although this approach is limited by the presence of mutation-specific restriction sites, patients with neuropathy, ataxia and retinitis pigmentosa (NARP) could benefit from it, as the T8399G mutation creates a unique restriction site that is not present in wild-type human mitochondrial DNA.
Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy (2012)

Compared with no treatment, cervical cerclage reduces the incidence of preterm birth in women at risk of recurrent preterm birth without statistically significant reduction in perinatal mortality or neonatal morbidity and uncertain long-term impact on the baby. Ceasarean section is more likely in women who had cervical suture inserted during pregnancy.The decision on how best to minimise the risk of recurrent preterm birth in women at risk, either because of poor history of a short or dilated cervix, should be 'personalised', based on the clinical circumstances, the skill and expertise of the clinical team and, most importantly, woman's informed choice.
A new mutation in the <i>puf</i>L gene responsible for the terbutryn resistance phenotype in <i>Rubrivivax gelatinosus</i> (1995)

Rubrivivax gelatinosus is a facultative phototrophic non-sulfur bacterium belonging to the beta subclass of the purple bacteria. A terbutryn-resistant mutant of R. gelatinosus has been isolated and characterized. Increased resistance levels to terbutryn (300-fold), atrazine (6-fold) and o-phenanthroline (3-fold) were observed for the mutant compared with wild type. Sequence analysis of the mutant revealed a new mutation in the pufL gene coding for the L subunit of the reaction centre (RC) at codon 192 leading to an amino-acid substitution from Gly in the wild type to Asp in the mutant. This substitution is located in the D helix of the L subunit, suggesting an interaction between terbutryn and this part of the polypeptide in the RC of R. gelatinosus. This is the first report of a mutation leading to herbicide resistance and affecting the D helix in purple bacteria. Furthermore R. gelatinosus wild type is highly sensitive to o-phenanthroline compared with other purple bacteria (Rhodobacter capsulatus and Rhodobacter sphaeroides). Sequence comparison of the L subunit from six purple bacteria in which o-phenanthroline sensitivity was measured suggests that SerL226 might be responsible for this phenotype.
<scp>IFN‐α</scp> subtypes: distinct biological activities in anti‐viral therapy (2012)

During most viral infections, the immediate host response is characterized by an induction of type I IFN. These cytokines have various biological activities, including anti-viral, anti-proliferative and immunomodulatory effects. After induction, they bind to their IFN-α/β receptor, which leads to downstream signalling resulting in the expression of numerous different IFN-stimulated genes. These genes encode anti-viral proteins that directly inhibit viral replication as well as modulate immune function. Thus, the induction of type I IFN is a very powerful tool for the host to fight virus infections. Many viruses evade this response by various strategies like the direct suppression of IFN induction or inhibition of the IFN signalling pathway. Therefore, the therapeutic application of exogenous type I IFN or molecules that induce strong IFN responses should be of great potential for future immunotherapies against viral infections. Type I IFN is currently used as a treatment in chronic hepatitis B and C virus infection, but as yet is not widely utilized for other viral infections. One reason for this restricted clinical use is that type I IFN belongs to a multigene family that includes 13 different IFN-α subtypes and IFN-β, whose individual anti-viral and immunomodulatory properties have so far not been investigated in detail to improve IFN therapy against viral infections in humans. In this review, we summarize the recent achievements in defining the distinct biological functions of type I IFN subtypes in cell culture and in animal models of viral infection as well as their clinical usage in chronic hepatitis virus infections.
Self‐Assembly of Cationic Dipeptides Forming Rectangular Microtubes and Microrods with Optical Waveguiding Properties (2014)

Rectangular microtubes and microrods are obtained using a slow solvent-evaporation method that induces the self-assembly of cationic diphenylalanine peptide (CDP). The microrods and microtubes have similar structures, but the microrods are single-crystalline. The microrods can be made fluorescent, revealing evident optical waveguiding properties.
아동,청소년 정신건강의 정책분석을 통한 활성화 방안 (2008)

본 연구는 한국의 아동?청소년 정신건강의 정책 및 제도를 분석하여 발전방안을 모색하고자, 현재까지 행해지고 있는 한국의 아동?청소년의 정신건강을 위한 정책 및 제도를 분석하였다. 분석 대상은 보건복지가족부와 여성부 및 정신보건센터의 정책자료, 법률 및 관련 문헌을 중심으로 분석하였다. 분석결과 한국의 아동?청소년 정신건강을 위한 정책은 2002년부터 정신보건센터를 중심으로 정신보건사업을 실행해 오고 있으나, 학령전기 아동에 대한 조기개입은 매우 부족한 실정이며, 아동?청소년 정신질환 유병율도 정확하게 파악하지 못하는 등 아동?청소년 정신건강에 대한 사회 공공대책은 아직 걸음마 단계에 머물러 있다. 그리고 공공치료 인프라와 의료 인프라도 크게 부족하며, 저소득층이 많이 이용하는 사회복지관들도 열악하고 복합적 정신질환을 앓고 있는 비행청소년을 위한 사회적 대책이 사실상 부재한 실정이다. 다시 말해서 우리나라의 현 상황은 아동?청소년 정신건강에 대해 중앙정부가 제 역할을 못하다 보니 의료기관과 복지관, 정신보건센터 등이 제각기 전투를 벌이는 상황이다. 또한 허술한 학교 정신건강 관리 체계, 아동?청소년들의 정신질환을 조기 발견해 도와줄 시스템 부족, 정신질환에 대한 교사들의 지식 부족 등 학교 정신보건 인프라도 열악한 상황이다. 이에 우리나라 아동?청소년 정신건강의 활성화를 위해 나아가야 할 방안은 아동?청소년 정신건강 문제에 대한 패러다임의 전환이 필요하고, 갈수록 늘어나는 정신질환 아동?청소년들을 효과적으로 치료하는 정책 마인드의 전환이 절실하다. 그리고 조기개입을 통한 정신건강 문제의 예방이 시급하며 지역사회 중심의 아동?청소년 정신건강 서비스의 전달체계를 마련하여 효율적인 정신건강 서비스를 실행할 수 있도록 해야 할 것이다. 마지막으로 가정과 학교, 사회의 조기치료 시스템 구축을 통하여 치료 효율성을 높일 수 있도록 해야 한다.
Flow injection analysis of binary and ternary mixtures of arsenite, arsenate, and phosphate (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlow injection analysis of binary and ternary mixtures of arsenite, arsenate, and phosphatePilar. Linares, Luque. De Castro, and Miguel. ValcarcelCite this: Anal. Chem. 1986, 58, 1, 120–124Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/ac00292a029https://doi.org/10.1021/ac00292a029research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synchronization of Dynamical Networks With Nonidentical Nodes: Criteria and Control (2010)

This paper presents a framework for global synchronization of dynamical networks with nonidentical nodes. Several criteria for synchronization are given using free matrices for both cases of synchronizing to a common equilibrium solution of all isolated nodes and synchronizing to the average state trajectory. These criteria can be viewed as generalizations of the master stability function method for local synchronization of networks with identical nodes to the case of nonidentical nodes. The controlled synchronization problem is also studied. The control action, which is subject to certain constraints, is viewed as reorganization of the connection topology of the network. Synchronizability conditions via control are put forward. The synchronizing controllers can be obtained by solving an optimization problem.
In vitro and in vivo hematopoietic activities of Betafectin PGG-glucan. (1998)

Betafectin PGG-glucan is a novel beta-(1,3)glucan that has broad-spectrum anti-infective activities without cytokine induction. Here we report that PGG-glucan also has both in vitro and in vivo hematopoietic activities. In vitro studies with bone marrow target cells from the C3H/HeN mouse revealed that although PGG-glucan alone had no direct effect on hematopoietic colony-forming cell (CFC) growth, when combined with granulocyte colony-stimulating factor (CSF) or granulocyte-macrophage CSF, it increased CFC numbers 1.5- to 2.0-fold over those obtained with CSFs alone. Bone marrow cells cultured for high-proliferative-potential CFCs in the presence of interleukin (IL)-1, IL-3, macrophage CSF, and stem cell factor (SCF), or cultured for erythroid burst-forming units in the presence of IL-3, SCF, and erythropoietin, also exhibited enhanced growth in the presence of PGG-glucan. The synergistic effect of PGG-glucan was specific and could be abrogated by anti-PGG-glucan antibody. The ability of PGG-glucan to modulate hematopoiesis in vivo was evaluated in myelosuppressed rodents and primates. C3H/HeN female mice were intravenously administered saline solution or PGG-glucan (0.5 mg/kg) 24 hours before the intraperitoneal administration of cyclophosphamide (200 mg/kg), and the recovery of bone marrow cellularity and granulocyte-macrophage progenitor cells was evaluated on days 4 and 8 after cyclophosphamide treatment. At both time points, enhanced hematopoietic recovery was observed in PGG-glucan-treated mice compared with saline-treated control mice. In a final series of in vivo experiments, we evaluated the ability of therapeutically administered PGG-glucan to enhance hematopoietic recovery in cyclophosphamide-treated cynomolgus monkeys. Monkeys received intravenous infusions of cyclophosphamide (55 mg/kg) on days 1 and 2, followed on days 3 and 10 by intravenous infusion of PGG-glucan (0.5, 1.0, or 2.0 mg/kg). Compared with those in saline-treated monkeys, accelerated white blood cell recovery and a reduction in the median duration of neutropenia were observed in PGG-glucan-treated monkeys. These studies illustrate that PGG-glucan has both in vitro and in vivo hematopoietic activities and that this agent may be useful in the prevention and/or treatment of chemotherapy-associated myelosuppression.
A importância da iniciação científica na formação acadêmica e profissional do aluno (2014)

Este artigo e resultado de uma participacao, como palestrante, no III Congresso de iniciacao Cientifica na FBMG, ocorrido em 24 e 25 de maio de 2013. A partir de uma importante tematica - Como fazer da pesquisa o diferencial profissional em tempos de concorrencias acirradas? - destacamos a importância da iniciacao cientifica na formacao academica e profissional do aluno. Por entendermos que a proposta foi desafiar os graduandos a tomar gosto pelo estudo, pela aprendizagem dentro e fora de sala de aula e pela pesquisa, a abordagem priorizou a gestao eficaz da vida academica, o que certamente envolve professores e alunos. Assim, os objetivos deste texto sao duplos. Em primeiro lugar, e realcar a importância da Iniciacao Cientifica na formacao academica e profissional do aluno, ja que o mundo do trabalho exige pessoas autonomas, criativas e comprometidas com a inovacao e com a producao de novos conhecimentos e produtos. Em segundo lugar, e enfatizar que as IES precisam cumprir uma importante exigencia que e vincular e sintonizar a pesquisa nos projetos pedagogicos dos seus diferentes cursos de graduacao.
Methylatropine blocks the central effects of cholinergic antagonists (1994)

These studies were conducted in order to establish the dose dependency and relative peripheral versus central activity of four prototypical cholinergic antagonists on the rodent passive avoidance response, a widely used animal model of retention. Subcutaneous administration of 0.1 to 100mg/kg revealed a potency profile of scopolamine > atropine methylscopolamine >/= methylatropine for the impairment of passive avoidance responding. A series of neurological assessments of the doses used indicated that side effects alone were not sufficient to impair passive avoidance responding. Although inactive when delivered peripherally, methylatropine was able to produce retention deficits at 10nmol (3.66µg) when administered intracerebrally. To further evaluate whether systemic methylatropine could enter the central nervous system, either scopolamine or atropine was administered subcutaneously in mice and rats pretreated with 10-100mg/kg methylatropine. The deficit-producing effects of scopolamine and atropine were abolished with methylatropine. Thus methylatropine is an exclusive peripheral antagonist; its ability to block the deficit-producing effects of scopolamine and atropine may occur through a change in blood-brain barrier permeability or through uncharacterized pharmacokinetic properties.
Serine Protease Inhibitor A3K Protects Rabbit Corneal Endothelium From Barrier Function Disruption Induced by TNF-α (2013)

SA3K exposure markedly reduced TNF-α-induced disruption of barrier structure and function in the rabbit corneal endothelium by maintaining AJC integrity. These protective effects are due to suppression of MLC activation. SA3K may have, in vivo, a therapeutic potential to offset TNF-α-induced declines in endothelial barrier structural integrity and function.
A novel technique for the determination of body fat by computed tomography. (1983)

We have developed a new method of measuring fat volume of the human body, using computed tomographic scanning (CT scan) - no ideal or direct method has been available for this calculation. In our study a human body is divided into 11 cylindrical shapes, ie a head, a chest, an abdomen, both sides of forearms, upper arms, thighs and calves to be subjected to the measurement. Eleven computed tomographic sections were examined at the middle point of each segment to obtain the areas of fat tissue. Volume of each cylindrical segment was calculated by multiplying a cross-sectional area of fat tissue by the height of each part. Then the volume of fat tissue of the whole body was determined by the sum of fat tissue volume of eleven parts (as above). By this method, nine massive obese subjects with 147-188 percent of ideal body weight were found to possess fat tissue occupying 30-63 percent of total body volume. We also found female obese patients had a significantly higher percentage of fat tissue than male obese patients when they had same degree of obesity. In addition to the study above, we examined 18 control and 19 obese subjects and measured subcutaneous fat, muscle plus bone and visceral fat separately by CT scan at the umbilicus level. In obese subjects, increased abdominal fatty mass was mainly due to the accumulation of subcutaneous fat, although substantial increase of visceral fatty mass was demonstrated in a few cases.
ChemInform Abstract: Palladium‐Catalyzed Coupling Reactions Between sp and sp2 Carbon Centers (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Community‐acquired respiratory viruses and co‐infection among patients of Ontario sentinel practices, April 2009 to February 2010 (2012)

Respiratory viral co-infections are commonly detected when using molecular techniques. Early sample collection increases likelihood of detection of co-infection. Further studies are needed to better understand the clinical significance of viral co-infection.
Type II collagen induced arthritis in rats: clinical and immunological studies. (1985)

Immunization of laboratory rats with native Type II collagen induces arthritis in approximately 40 percent of the individuals. Histological and radiological analysis have suggested that the lesion bears several similarities to human rheumatoid arthritis. Clinical studies conducted with this model indicate that it is responsive to the treatment with clinically-used NSAID'S, steroids and immunosuppressive agents. When rats with collagen arthritis were treated with DMARD's, only those treated with D-penicillamine showed clinical improvement (radiological evaluation). Type II collagen induced arthritis is complement-dependent and is an example of an immune complex mediated injury. Thus, passive arthritis can be induced in rats by the intravenous administration of affinity-purified anticollagen IgG. The passive lesion is transient and the administered IgG is detected on the articular cartilage of the hind paws. This articular cartilage also contains complement C3. Passive arthritis is also complement-dependent. Suppression of Type II collagen arthritis can be induced by the prior intravenous treatment of rats with either Type II collagen or its constituent peptide alpha 1, (II) CB10. Antigen-induced arthritis cannot be induced in those rats that have recovered from passive arthritis.
A New Rapid Quantitative Test for Fecal Calprotectin Predicts Endoscopic Activity in Ulcerative Colitis (2013)

FC determined by QPOCT was an accurate surrogate marker of "endoscopic remission" in UC and presented a good correlation with the FC-ELISA test.
Stability and convergence in strongly monotone dynamical systems. (1988)

Soit (X, Φ) un systeme dynamique: X est un espace topologique et le flot Φ={Φ t } t∈R+ est une famille d'applications continues de sous-ensembles ouverts de X dans X. On decrit qualitativement le comportement asymptotique quand t→∞ des trajectoires t→Φ t x pour les etats initiaux x, dans le cas de systemes ayant un principe de comparaison fort
The Business of iPhone and iPad App Development (2011)

The phenomenal success of the iPhone, iPad and the iPod touch has ushered in a “gold rush” for developers, but with well over 300,000 apps in the highly competitive App Store, it has become increasing
The Tribological Effect of Electrolytically Produced Micro-pools and Phosphoric Compounds on Medium Carbon Steel Surfaces in Rolling - Sliding Contact (2001)

Vigorous electro-polishing of tooth faces can improve the pitting durability of medium carbon steel gearing under severe load and/or poor lubrication conditions. This is attributed to the effect of micro-pools and phosphoric compounds electrolytically produced on the steel surfaces. This paper investigates the effect of such vigorous electrolytic polishing on the medium carbon steel surfaces with special attention to asperity interaction during run-in process in the early stage of operation, using a two-roller testing machine. The results are compared with those of circumferentially ground surfaces. The following facts are concluded. The asperity interaction is quickly reduced and oil film creation is improved by the electro-polishing, especially under severe loading.
Observation of 20 eV x-ray generation in a proof-of-principle laser synchrotron source experiment (1995)

A laser synchrotron source (LSS) [P. Sprangle, A. Ting, E. Esarey, and A. Fisher, J. Appl. Phys. 72, 5032 (1992)] was proposed to generate short-pulsed, tunable x rays by Thomson scattering of laser photons from a relativistic electron beam. A proof-of-principal (p.o.p.) experiment on this LSS configuration is performed. An intense laser pulse (λ0=1.053 μm) is Thomson backscattered from a focused relativistic electron beam. Time integrated x-ray signals from a photocathode/electron multiplier, at an electron beam energy of 650 keV and an x-ray photon energy of 20 eV, indicate an increase in the x-ray signals above the baseline by an amount comparable to the theoretically predicted value.
Monopulse scanning beam planar array for signal identification system (2006)

An antenna for a Signal Identification System has been designed. The objective of this design is to detect the angle of the arrival signal by electronic sweeping and a monopulse system in the horizontal plane. The antenna frequency performance is fixed at 1.06 GHz with an 80 MHz bandwidth (7.54 %). A ±60° sweeping of the aiming angle signal with a 3 dB loss level in the edges is desired, as well as a 22 dB maximum gain of the total antenna, but the minimum coverage is ±45°. For all these reasons, a planar array antenna is designed with a number of 40 radiating elements and divided into 10 columns and 4 rows. Each column is connected to a phase shifter and all columns are fed through a hybrid stripline network.