gebhart/patrepeval huggingface dataset:
Evidence of hyaluronan in human tears and secretions of conjunctival cultures (1994)

Conference Article| May 01 1994 Evidence of hyaluronan in human tears and secretions of conjunctival cultures MANDY FRESCURA; MANDY FRESCURA 1Department of Ophthalmology, Bristol Eye Hospital, Bristol BS1 2LX UK Search for other works by this author on: This Site PubMed Google Scholar MONICA BERRY; MONICA BERRY 1Department of Ophthalmology, Bristol Eye Hospital, Bristol BS1 2LX UK Search for other works by this author on: This Site PubMed Google Scholar ANTHONY CORFIELD; ANTHONY CORFIELD +Department of Medicine Labs., Bristol Royal Infirmary, Bristol BS2 8HW UK Search for other works by this author on: This Site PubMed Google Scholar STEPHEN CARRINGTON; STEPHEN CARRINGTON *School of Veterinary Medicine, Southwell Street, Bristol BS2 8EJ UK Search for other works by this author on: This Site PubMed Google Scholar DAVID L. EASTY DAVID L. EASTY 1Department of Ophthalmology, Bristol Eye Hospital, Bristol BS1 2LX UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (2): 228S. https://doi.org/10.1042/bst022228s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation MANDY FRESCURA, MONICA BERRY, ANTHONY CORFIELD, STEPHEN CARRINGTON, DAVID L. EASTY; Evidence of hyaluronan in human tears and secretions of conjunctival cultures. Biochem Soc Trans 1 May 1994; 22 (2): 228S. doi: https://doi.org/10.1042/bst022228s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Allelic variations and differential expressions detected at quantitative trait loci for salt stress tolerance in wheat (2017)

The increasing salinization of agricultural lands is a threat to global wheat production. Understanding of the mechanistic basis of salt tolerance (ST) is essential for developing breeding and selection strategies that would allow for increased wheat production under saline conditions to meet the increasing global demand. We used a set that consists of 150 internationally derived winter and facultative wheat cultivars genotyped with a 90K SNP chip and phenotyped for ST across three growth stages and for ionic (leaf K<sup>+</sup> and Na<sup>+</sup> contents) traits to dissect the genetic architecture regulating ST in wheat. Genome-wide association mapping revealed 187 Single Nucleotide Polymorphism (SNPs) (R<sup>2</sup> = 3.00-30.67%), representing 37 quantitative trait loci (QTL), significantly associated with the ST traits. Of these, four QTL on 1BS, 2AL, 2BS and 3AL were associated with ST across the three growth stages and with the ionic traits. Novel QTL were also detected on 1BS and 1DL. Candidate genes linked to these polymorphisms were uncovered, and expression analyses were performed and validated on them under saline and non-saline conditions using transcriptomics and qRT-PCR data. Expressed sequence comparisons in contrasting ST wheat genotypes identified several non-synonymous/missense mutation sites that are contributory to the ST trait variations, indicating the biological relevance of these polymorphisms that can be exploited in breeding for ST in wheat.
Desulfurization and demineralization of miike coal by molten alkali hydroxides. (1987)

Pulverized Miike coal was treated in molten mixtures of sodium hydroxide and potassium hydroxide at 473-673K. The removal yield of total sulfur, organic sulfur and ash and the change in heating value and volatile matter content were evaluated as functions of coal size, alkali composition, reaction temperature, and reaction time.No effect of the coal size was observed when the coal was crushed under 300/μm. The rate of demineralization was faster than that of desulfurization. The optimum conditions of temperature and treatment time were 623K and 60min, respectively. The removal yields of sulfur and ash based on the mass of treated coal were not increased under more severe condi-tions because of the decomposition of coal. An increase in the KOH concentration resulted in a higher sulfur removal yield and a lower heating value. The best KOH concentration was about 50wt%.Under most suitable conditions, the removal yields of total sulfur and ash were 92% (sulfur residue 0.27wt%, db) and 96% (ash residue 0.58wt%, db), respectively. The heating value per dry mass of clean coal was increased by about 7% than the original coal.
Studies of age‐related impairments in regenerative capacity in adult mammals using the rodent bladder (2011)

Although models of organ regeneration in lower vertebrates (e.g., urodeles) have been utilized to identify mechanisms involved in regeneration, more relevant models in animals closer to humans phylogenetically are lacking. We previously reported on a rodent model of bladder regeneration, where removal of ~70% of the bladder (subtotal cystectomy; STC) induces a regenerative response in 12 week old female rats, such that normal volume and function are restored within 8 weeks. Herein we report on the impact of age on the remodeling/regenerative response of the bladder after STC in 12 month old females. Cystometric studies revealed that bladder capacity 8 weeks post-STC was 60% of age-matched controls, and maximum pressures generated in bladders 8 weeks post-STC (33.3 ± 4.5 cmH2O) were also low compared to controls (56.7 ± 4.8cmH2O). H&E staining of excised kidneys revealed damage consistent with hydronephrosis in STC animals, and was accompanied by a significant increase in kidney weight (STC animals: 1.10 +/− 0.03; controls: 0.99+/− 0.02g). These data clearly demonstrate an age-related decline in regenerative capacity of the bladder, potentially leading to end stage renal disease. As such, the rodent bladder may provide mechanistic insight on the salient features of impaired regeneration, which may lead to new therapeutic possibilities for tissue repair/regeneration. This research supported by R21DK081832.
Oxidation of Benzylic Alcohols and Ethers to Carbonyl Derivatives by Nitric Acid in Dichloromethane. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Recent considerations in the treatment of hypothyroidism. (2008)

Thyroid hormone deficiency has been recognized and treated with various forms of thyroid hormone replacement over the last century. Since the 1950s, synthetic L-thyroxine has been the therapy of choice. However, there is now recognition that the currently available regimens for the treatment of hypothyroidism may not adequately address the needs of all patients. This review summarizes recent considerations in the field of thyroidology to address the potential for improvement in the treatment of patients. The goal of these improvements should be to achieve both clinical and chemical euthyroidism.
Morphological traits and high resolution RAPD markers for the identification of the main strawberry varieties cultivated in Argentina (2002)

Abstract Eight genotypes of the main Fragaria × ananassa cultivars grown in Argentina were analysed using the random amplified polymorphic DNA (RAPD) technique combined with electrophoresis in polyacrylamide gels. The high resolution of this procedure allowed the detection, with only 13 random primers, of 37 genotype‐specific bands that can be used as markers for verifying the identity of cultivars. By using this approach, three different accessions of the cultivar ‘Pájaro’ exhibited differences in amplification profiles, confirming the need for DNA analysis to prevent misidentification of cultivars. In addition, RAPD bands and morphological traits were used to assess genetic relatedness among cultivars. Comparison of both dendrograms revealed that there is no correlation between the clustering obtained with molecular and morphological characters.
RUBIACEAE (2006)

CORRECT AUTHOR CITATIONS FOR NAMES OF THREE SOUTHERN AFRICAN SPECIES OF CANTHIUM
Response: To the Comments by Drs. W. Shyy and M. Sindir (1994)

Technical Forum Response: To the Comments by Drs. W. Shyy and M. Sindir Christopher J. Freitas Christopher J. Freitas Southwest Research Institute, San Antonio, TX 78284 Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Christopher J. Freitas Southwest Research Institute, San Antonio, TX 78284 J. Fluids Eng. Jun 1994, 116(2): 198 (1 pages) https://doi.org/10.1115/1.2910253 Published Online: June 1, 1994 Article history Online: May 23, 2008
Polylactides: properties and prospects of an environmentally benign plastic from renewable resources (2001)

Pressing environmental and economic concerns dictate the need to develop new synthetic macromolecules based on renewable resources. The vast majority of existing materials are based on non-renewable fossil resources that will eventually be extinguished. Manufacturing synthetic polymers and disposal by incineration produces CO2 and contributes to global warming. For these reasons, poly(lactic acid) (PLA) polymers are of increasing commercial interest because they are derived from a renewable resources, sequester significant quantities of carbon dioxide relative to petrochemical based materials, conserve energy, and easily degrade. The mechanical properties of PLA are compared to other commodity plastics and it is shown that PLA closely resembles polystyrene. The effects of blending linear and branched chain architectures are discussed and it is shown that this provides a convenient method for controlling the elasticity and viscosity of the composite material without affecting mechanical or permeation properties. The melt rheology of high L content linear PLAs shows two unique features; they may be drawn to large Hencky strains without breaking and they exhibit considerable strain hardening. As a result, PLA is easily processed into fiber form. Due to the excellent combination of mechanical, rheological, and environmental properties, the prospects for widespread commercialization of PLA are excellent.
Preparation and reactions of fluorosulfonyliminosulfuroxy difluoride. XVII (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and reactions of fluorosulfonyliminosulfuroxy difluoride. XVIIHerbert W. Roesky and Daniel P. BabbCite this: Inorg. Chem. 1969, 8, 8, 1733–1735Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/ic50078a033https://doi.org/10.1021/ic50078a033research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Growth regulation of human acute myeloid leukemia: effects of five recombinant hematopoietic factors in a serum-free culture system (1988)

The response of human acute myeloid leukemia (AML) cells to the distinct hematopoietic growth factors (HGFs), ie, recombinant interleukin-3 (IL-3), granulocyte-macrophage-CSF (GM-CSF), granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF), and erythropoietin (Epo) was investigated under well-defined serum-free conditions. Proliferative responses to these factors, when added separately as well as in combinations, were analyzed in 25 cases of human AML using 3H-thymidine incorporation and colony assays. The 3H-thymidine uptake data revealed that IL-3, GM-CSF, G-CSF, and M-CSF were stimulators of AML proliferation in 19, 15, 13, and 4 cases, respectively. Epo only stimulated DNA synthesis in the cells of the single erythroleukemia case. GM-CSF stimulation was seen only in IL-3 reactive cases and GM-CSF, when combined with IL-3, could not further elevate the DNA synthesis evoked by IL-3 alone. On the other hand, in six cases, G-CSF enhanced the IL-3- or GM-CSF-stimulated thymidine uptake. These results suggest that subpopulations of AML cells that are activated by distinct CSFs (eg, IL-3/GM-CSF-responsive cells and G-CSF-responsive cells) coexist. The 3H-thymidine incorporation assay was more sensitive for measuring CSF responses than methylcellulose colony cultures, since activation of DNA synthesis was more frequently seen than induction of colony formation. DNA synthesis experiments revealed eight different CSF response patterns among these 25 cases. CSF phenotyping may be a useful addition to the morphologic classification of AML, since these patterns directly reflect the ability of the proliferating subsets of AML cells to respond to the CSFs.
Add-on Trial of Clobazam in Intractable Adult Epilepsy with Plasma Level Correlations (1990)

Clobazam, a novel benzodiazepine, was used as an add-on agent in 47 adult patients with intractable epilepsy and a variety of seizure types. A greater than 75% reduction in seizure frequency was observed in 42% (18) of the patients and a greater than 50% reduction in 65% (29) of the patients which was sustained over a mean follow-up period of 13.3 (+/- 5.6) months. Nine patients had to discontinue the drug due to minor adverse effects or increased seizures. Possible tolerance developed in 6 patients. Plasma levels of the active metabolite N-desmethylclobazam were linearly related to dosage and appeared to correlate with both therapeutic and toxic responses. Clobazam appears to be a safe and effective add-on antiepileptic for a wide variety of seizure types in intractable epilepsy.
An 8-Week Low-Intensity Progressive Cycling Training Improves Motor Functions in Patients with Early-Stage Parkinson's Disease (2018)

Our pioneer study has demonstrated that a low-intensity progressive cycling exercise can improve motor function in PD, especially akinesia. The beneficial effects were similar to those of high-intensity rehabilitation programs.
An Apparatus for the Measurement of Lipoxygenase Activity and Pentane Production I (1974)

The enzyme lipoxygenase has been demonstrated to produce pentane. However, until now no apparatus has been available to measure the pentane concomitantly with the lipoxygenase activity. Such an apparatus is described by this paper. The apparatus consists of a reaction vessel which can be sealed with a rubber septum to allow sampling for pentane production and an oxygen measuring device to determine the oxygen level of the system. The apparatus is being used to conduct in-depth studies of the lipoxygenase enzyme and its possible role in food quality. INTR ODUCTI ON Pattee, et al., (l) demonstrated that five major volatile compounds were produced during maturation of the peanut seed, with pentane production dominant during the middle and late maturation stages. They postulated that pentane is produced in a reaction sequence starting with the action of lipoxygenase on linoleic acid. To study this further a simple apparatus for the measurement of both lipoxygenase 1paper 4128 of the journal series of the North Carolina State
Category Norms as a Function of Culture and Age: Comparisons of Item Responses to 105 Categories by American and Chinese Adults. (2004)

Understanding how aging influences cognition across different cultures has been hindered by a lack of standardized, cross-referenced verbal stimuli. This study introduces a database of such item-level stimuli for both younger and older adults, in China and the United States, and makes 3 distinct contributions. First, the authors specify which item categories generalize across age and/or cultural groups, rigorously quantifying differences among them. Second, they introduce novel, powerful methods to measure between-group differences in freely generated ranked data, the rank-ordered logit model and Hellinger Affinity. Finally, a broad archive of tested, cross-linguistic stimuli is now freely available to researchers: data, similarity measures, and all stimulus materials for 105 categories and 4 culture-by-age groups, comprising over 10,000 fully translated unique item responses.
Development of cohesive self-healing gels based on self-assembly of organic and inorganic nanoparticles (2013)

Noncovalent bonds are often reversible and sensitive to external stimuli. Although noncovalent interactions are inherently weak and generally perceived as inadequate to construct macroscopic materials of sufficient integrity and cohesion, the emergence of nanotechnology has shown that the intrinsic weakness of noncovalent interactions can be compensated by maximizing the number of these bonds that work in concert. In that way, remarkably strong materials can be formed. colloidal gels are an emerging and particularly attractive class of cohesive hydrogels. These materials allow for bottom-up design of functional materials by employing noncovalent interactions between micro- or nanoscale particles as building blocks to assemble into shape-specific bulk materials. In an attempt to explore the feasibility of using electrostatic and hydrophobic interactions between nanoparticles, it was recently observed that colloidal gels made of oppositely charged gelatin nanospheres were surprisingly cohesive, elastic and self-healing. In the current study, we aim to extend this concept towards self-healing colloidal gels by synthesizing organic nanoparticles that exhibit a strong affinity for inorganic nanoparticles using various types of bioinspired derivatization strategies. The organic nanoparticles impart flexibility and resilience to these gels, while the inorganic nanoparticles improve their hardness and rigidity.
Biodegradation of PVA‐based formulations (1999)

Abstract Investigation of the biodegradability of water soluble poly(vinyl alcohol) (PVA) based blown films was carried out under different lab‐scale environmental conditions. In particular respirometric tests were utilized in order to evaluate the biodegradability of PVA films in composting, in modified Sturm test and in soil burial simulation tests. Several microbial inocula present in river water, mature compost, forest and farm soils as well as sewage sludge from municipal and paper mill wastewater treatments plants were utilized for the relevant tests. A mixed PVA‐degrading microbial culture was obtained by a common enrichment procedure by using sewage sludge from paper mill as inoculum; this culture was tentatively utilized for the isolation of single PVA‐degrading microorganisms. As a first result we can stress that significant biodegradation extent in fairly low incubation time can be obtained only in the presence of acclimated microbial populations such as those deriving from paper mill sewage sludge, in liquid cultures. Nevertheless separation of single degrading microbial species was impossible most likely due to the establishment of symbiotic or commensal interactions between the single components of the PVA‐degrading mixed cultures. On the other hand, limited mineralization rates were recorded in solid cultures in the presence of soil or compost. Finally, a mechanism of degradation of polymer chains unlike random or unzipping was suggested in the presence of either PVA‐degrading mixed culture and its filtrate by means of viscometric determinations of molecular weight within the time.
An outbreak of cyclosporiasis in Florida in 1995: a harbinger of multistate outbreaks in 1996 and 1997. (1998)

Before 1995, only one outbreak of cyclosporiasis had been reported in the United States. To identify risk factors for Cyclospora infection acquired in Florida in 1995, we conducted a matched case-control study (24 sporadic cases and 69 controls) and retrospective cohort studies of clusters of cases associated with two May social events (attack rates = 15.4% [8 of 52] and 54.5% [6 of 11]). In univariate analysis of data from the case-control study, consumption of fresh raspberries (odds ratio [OR] = 6.0, 95% confidence interval [CI] = 1.1-31.7) and bare-handed contact with soil (OR = 5.4, 95% CI = 1.4-20.7) were associated with infection; soil contact was also implicated in multivariate analysis. For the events, mixed-fruit items that had only fresh raspberries and strawberries in common had elevated relative risks (3.7 and 4.2), but the confidence intervals overlapped 1.0. The raspberries eaten at the events and by sporadic case-patients were imported. Given the cumulative evidence of the three studies and the occurrence in 1996 and 1997 of outbreaks in North America associated with consumption of Guatemalan raspberries, food-borne transmission of Cyclospora was likely in 1995 in Florida as well.
Effect of the Pairing Gene Ph1 and Premeiotic Colchicine Treatment on Intra- and Interchromosome Pairing of Isochromosomes in Common Wheat (1998)

The analysis of the pattern of isochromosome pairing allows one to distinguish factors affecting presynaptic alignment of homologous chromosomes from those affecting synapsis and crossing-over. Because the two homologous arms in an isochromosome are invariably associated by a common centromere, the suppression of pairing between these arms (intrachromosome pairing) would indicate that synaptic or postsynaptic events were impaired. In contrast, the suppression of pairing between an isochromosome and its homologous chromosome (interchromosome pairing), without affecting intrachromosome pairing, would suggest that homologous presynaptic alignment was impaired. We used such an isochromosome system to determine which of the processes associated with chromosome pairing was affected by the Ph1 gene of common wheat-the main gene that restricts pairing to homologues. Ph1 reduced the frequency of interchromosome pairing without affecting intrachromosome pairing. In contrast, intrachromosome pairing was strongly reduced in the absence of the synaptic gene Syn-B1. Premeiotic colchicine treatment, which drastically decreased pairing of conventional chromosomes, reduced interchromosome but not intrachromosome pairing. The results support the hypothesis that premeiotic alignment is a necessary stage for the regularity of meiotic pairing and that Ph1 relaxes this alignment. We suggest that Ph1 acts on premeiotic alignment of homologues and homeologues as a means of ensuring diploid-like meiotic behavior in polyploid wheat.
Aberrant accumulation of phospholipase C-delta in Alzheimer brains. (1991)

Since phosphoinositide-specific phospholipase C (PLC) is one of the key molecules in signal transduction, the authors assessed its involvement in Alzheimer's disease (AD). Immunostaining of a specific antibody against the PLC isozyme, PLC-delta, demonstrated that this enzyme was abnormally accumulated in neurofibrillary tangles (NFT), the neurites surrounding senile plaque (SP) cores, and neuropil threads in AD brains. Western blot analysis confirmed that PLC-delta was concentrated in the paired helical filament (PHF)-rich fraction of AD brains. Antibodies to other PLC isozymes did not produce positive immunostaining of these pathologic structures. Moreover, diffuse and amorphous deposits of PLC-delta were found to precede the accumulation of fibrillary deposits. These results suggest that PLC-delta accumulation is a crucial event that ultimately may contribute to the formation of PHF.