gebhart/patrepeval huggingface dataset:
Application of 3G PCS technologies to rapidly deployable mobile networks (2002)

In this article, a rapidly deployable PCS architecture based on our novel resource management scheme, namely, virtual cell layout (VCL), is introduced. VCL is used to develop new self-organization and routing procedures that mitigate the scalability problem of infrastructureless routing and resource management. In VCL, the communication area is tessellated with regularly shaped fixed-size virtual cells. Radio resources such as frequency carriers and CDMA codes are assigned to the fixed cells of this layout. The real cells, which do not need to be the some size as the virtual cells, can move over the VCL cells. Simulation results show that the VCL-based architecture satisfies the requirement for rapid deployment and can provide an acceptable grade of service.
Identification of Biotic and Abiotic Particles by Using a Combination of Optical Tweezers and In Situ Raman Spectroscopy (2004)

A highly versatile setup, which introduces an optical gradient trap into a Raman spectrometer, is presented. The particular configuration, which consists of two lasers, makes trapping independent from the Raman excitation laser and allows a separate adjustment of the trapping and excitation wavelengths. Thus, the excitation wavelength can be chosen according to the needs of the application. We describe the successful application of an optical gradient trap on transparent as well as on reflective, metal-coated microparticles. Raman spectra were recorded from optically trapped polystyrene beads and from single biological cells (e.g., erythrocytes, yeast cells). Also, metal-coated microparticles were trapped and used as surface enhanced Raman spectroscopy (SERS) substrates for tests on yeast cells. Furthermore, the optical gradient trap was combined with a SERS fiber probe. Raman spectra were recorded from trapped red blood cells using the SERS fiber probe for excitation.
SDK: A proposal of a general and efficient deterministic sampling sequence (2007)

Previous works have already demonstrated that deterministic sampling can be competitive with respect to probabilistic sampling in sampling-based path planners. Nevertheless, the definition of a general sampling sequence for any d-dimensional Configuration Space satisfying the requirements needed for path planning is not a trivial issue. This paper makes a proposal of a simple and yet efficient deterministic sampling sequence based on the recursive use, over a multi-grid cell decomposition, of the ordering of the 2 d descendant cells of any parent cell. This ordering is generated by the digital construction method using a d×d matrix Td. A general expression of this matrix (i.e. for any d) is introduced and its performance analyzed in terms of the mutual distance. The paper ends with a performance evaluation of the use of the proposed deterministic sampling sequence in different well known path planners.
Hypertension as a Biomarker of Efficacy in Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib (2011)

In patients with metastatic renal cell carcinoma, sunitinib-associated HTN is associated with improved clinical outcomes without clinically significant increases in HTN-associated adverse events, supporting its viability as an efficacy biomarker.
Greasing the Wheels for Ebola Immunization (2003)

Although investigators have developed a vaccine that protects against Ebola virus infection in nonhuman primates, it takes 6 months to produce protective immunity -- too long to halt localized outbreaks of Ebola. A new strategy, using an adenoviral vector that expresses Ebola antigens, may shorten that critical interval.

Encouraged by preliminary …
Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis (2005)

Our data support the hypothesis that early increased, not decreased, inflammatory response as measured by our markers is associated with improved survival rate. A high negative correlation was found between some of these markers and Sequential Organ Failure Assessment score.
Acetyl coenzyme A-dependent binding of carcinogenic and mutagenic dinitropyrenes to DNA (1985)

Dinitropyrenes are mutagenic and carcinogenic environmental pollutants found in diesel emissions and urban air particulates. In Salmonella typhimurium these compounds appear to be activated to mutagens by sequential nitroreduction and acetylation. We have examined whether or not similar activation pathways occur with mammalian nitroreductases and acetylases. When rat liver cytosol, NADPH and calf thymus DNA were incubated with [4,5,9,10(-3)H]1-nitropyrene, [4,5,9,10(-3)H]1,3-, 1,6- or 1,8-dinitropyrene very low levels of nitrated pyrene binding with DNA were detected. Addition of acetyl coenzyme A (AcCoA) to these incubations increased the binding of dinitropyrenes 20- to 40-fold while the binding of 1-nitropyrene was not affected. The extent of AcCoA-dependent binding of dinitropyrenes reflected the amount of nitroreduction, as measured by aminonitropyrene formation. However, the increase in binding of dinitropyrenes to DNA in the presence of AcCoA did not occur with dog liver cytosol which is known to be deficient in N-acetylases. These results suggest that cytosolic nitroreductases catalyze the formation of N-hydroxy arylamine intermediates which in the case of dinitropyrenes are converted to reactive N-acetoxy arylamines by cytosolic AcCoA-dependent acetylases.
Novel Conformationally Extended Naphthalene-Based Inhibitors of Farnesyltransferase (1997)

ADVERTISEMENT RETURN TO ISSUELetterNEXTNovel Conformationally Extended Naphthalene-Based Inhibitors of FarnesyltransferaseChristopher J. Burns, Jean-Dominique Guitton, Bernard Baudoin, Yves Lelièvre, Marc Duchesne, Fabienne Parker, Nadine Fromage, and Alain CommerçonView Author Information Rhône-Poulenc Rorer S. A., Centre de Recherches de Vitry-Alfortville, 13, Quai Jules Guesde, B. P. 14, 94403 Vitry-sur-Seine, France Cite this: J. Med. Chem. 1997, 40, 12, 1763–1767Publication Date (Web):June 6, 1997Publication History Received27 February 1997Published online6 June 1997Published inissue 1 June 1997https://pubs.acs.org/doi/10.1021/jm9701177https://doi.org/10.1021/jm9701177rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views312Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Conformation,Inhibition,Inhibitors,Monomers,Peptides and proteins Get e-Alerts
Structure and transport properties of coherently strained La<sub>2/3</sub>Ca<sub>1/3</sub>MnO<sub>3</sub>/SrTiO<sub>3</sub>superlattices (2005)

Abstract We have prepared high quality, coherently strained La 2/3 Ca 1/3 MnO 3 /SrTiO 3 superlattices with different modulation periods by laser molecular beam epitaxy on (001) SrTiO 3 and NdGaO 3 substrates. A detailed structural characterization was performed by high‐angle X‐ray diffraction (HAXRD) and low‐angle X‐ray reflectivity (LAXRR). All superlattices are very flat, show excellent structural coherence and very small mosaic spread (0.02°). The in‐plane coherency strain was varied by changing the thickness ratio of the constituent layers allowing for a systematic variation of the resulting tetragonal distortion of LCMO. The c ‐axis lattice parameter of LCMO could be continuously changed from 3.87 Å to 3.79 Å. The interface roughness was analyzed by offset low‐angle X‐ray reflectivity and low‐angle rocking curve measurements. It was found to be of the order of one unit cell with a significant part of the roughness being vertically correlated. The strain induced tetragonal distortion of LCMO was found to cause strong reduction of the paramagnetic to ferromagnetic transition temperature from about 260 to 120 K and an increase of resistivity. The transport properties in the paramagnetic regime could be well described by a small polaron hopping model. The lattice distortions were found to result in a significant increase of the polaron trapping energy. Our results show that coherently strain superlattices are an interesting model system for the systematic study of the effect of lattice distortions on the magnetic and electronic properties of the doped manganites. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Study on ion-coating surface treatment of dental alloys for adhesion. Part 2. Effect of sn and Cu-Sn target on Au-Ag-Pd alloy. (1989)

Previous study found that ion coating treatment with Cu target demanded 10 minutes of treatment to achieve the durable adhesion with 4-META resin. For clinical application, it's indispensable to shorten the treatment period. Sn and Cu-Sn target were examined in this study. 4 minutes of treatment with Sn target showed high bond strength of adhesion. However, the excess of treatment time over 8 minutes caused the remarkable decrease of adhesion durability against thermal cycling. In clinical situation, many of the prosthesis possess the wings of complex shape and it's difficult to attain the uniform coating by only once treatment. However, the repetition of treatment with Sn target is undesirable because of the decrease of adhesion durability. Favorable result was shown by 4 minutes of treatment with Cu-Sn target and even by 30 minutes of treatment, same result was attained. With this ion treated specimens of Au-Ag-Pd alloy sandblasted, the adhesive bond strength of above 200 kgf/cm2 was maintained after 100,000 thermocycles.
Nitrogen Incorporation Kinetics during the Sublimation Growth of 6H and 4H SiC (1996)

Nitrogen incorporation kinetics during the sublimation boule growth of SiC have been studied in terms of several growth parameters. 6H and 4H SiC crystals were heavily doped with nitrogen as a donor. It was found that the growth rate has little influence on the doping concentration, indicating that nitrogen incorporation is not kinetically limited at normal growth rates in the sublimation growth. On the other hand, surface polarity and polytype were found to influence the nitrogen incorporation kinetics at the growth front. By optimizing the growth conditions, bulk resistivities as low as 7.6×10 -3 Ω cm and 5.3×10 -3 Ω cm were obtained for 6H and 4H SiC, respectively.
521. [K <sup>1</sup> . 2. e.] Note on the Distances of the In-centre and Ex-centres of a Triangle from any Vertex (1917)

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Effect of nitrogen intake on nitrogen recycling and urea transporter abundance in lambs12 (2004)

Urea recycling in ruminants has been studied extensively in the past, but the mechanisms regulating the amount of urea recycled or excreted remain obscure. To elucidate the role of urea transporters (UT) in N recycling, nine Dorset-Finn ewe lambs (20.8 +/- 0.8 kg) were fed diets containing 15.5, 28.4, and 41.3 g of N/kg of DM for 25 d. Nitrogen balance and urea N kinetics were measured during the last 3 d of the period. Animals were then slaughtered and mucosa samples from the rumen, duodenum, ileum, and cecum, as well as kidney medulla and liver, were collected. Increasing N intake tended to increase N balance quadratically (1.5, 5.1, and 4.4 +/- 0.86 g of N/d, P < 0.09), and linearly increased urinary N excretion (2.4, 10, and 16.5 +/- 0.86 g N/d, P < 0.001) and plasma urea N concentration (4.3, 20.3, and 28.4 +/- 2.62 mg of urea N/dL, P < 0.001), but did not affect fecal N excretion (5.0 +/- 0.5 g of N/d; P < 0.94). Urea N production (2.4, 11.8, and 19.2 +/- 0.83 g of N/d; P < 0.001) and urinary urea N excretion (0.7, 7.0, and 13.4 +/- 0.73 g N/d; P < 0.001) increased linearly with N intake, as well as with the urea N recycled to the gastrointestinal tract (1.8, 4.8, and 5.8 +/- 0.40 g of N/d, P < 0.001). No changes due to N intake were observed for creatinine excretion (518 +/- 82.4 mg/d; P < 0.69) and clearance (46 +/- 10.7 mL/min; P < 0.56), but urea N clearance increased linearly with N intake (14.9, 24.4, and 34.9 +/- 5.9 mL/min; P < 0.04). Urea N reabsorption by the kidney tended to decrease (66.3, 38.5, 29.1 +/- 12.6%; P < 0.06) with increasing N content of the diet. Increasing the level of N intake increased linearly the weight of the liver as a proportion of BW (1.73, 1.88, and 2.22 +/- 0.15%, P < 0.03) but only tended to increase the weight of the kidneys (0.36, 0.37, and 0.50 +/- 0.05%, P < 0.08). Urea transporter B was present in all the tissues analyzed, but UT-A was detected only in kidney medulla, liver, and duodenum. Among animals on the three diets, no differences (P > 0.10) in UT abundance, quantified by densitometry, were found. Ruminal-wall urease activity decreased linearly (P < 0.02) with increasing level of N intake. Urease activity in duodenal, ileal, and cecal mucosa did not differ from zero (P > 0.10) in lambs on the high-protein diet. In the present experiment, urea transporter abundance in the kidney medulla and the gastrointestinal tract did not reflect the increase in urea-N reabsorption by the kidney and transferred into the gut.
Conversion Technologies for the Production of Liquid Fuels and Biochemicals (2014)

Lignocellulosic biomass such as agricultural and forestry residues and herbaceous energy crops can serve as low-cost renewable feedstock for many, next-generation, bio-derived products. Over the years, numerous research and development efforts have been undertaken to develop and apply new cost-efficient conversion processes for lignocellulosic biomass. This chapter gives an overview of the conversion technologies for liquid fuels and biochemicals. Generally, two main routes for the conversion of lignocellulosic biomass can be distinguished, which can lead to the production of biofuels and other value-added commodity chemicals: the biochemical route and the thermochemical route. Biochemical conversion makes use of the enzymes of bacteria or other microorganisms to break down and convert the biomass. Thermochemical conversion includes processes in which heat and pressure are the dominant mechanisms to convert the biomass into another chemical form. Further research is needed to develop commercially viable processes utilizing the two technologies.
Reactions of 5‐Methylsulfinyl‐1‐(4‐nitrophenyl)tetrazole with N‐Nucleophiles. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
L. J. Mason and N. M. J. Woodhouse Integrability, self-duality and twistor theory (London Mathematical Society Monographs (New Series) No. 15, Clarendon Press, Oxford, 1996), x + 364pp., 0 19 853498 1, (hardback) £45. (1998)

L. J. Mason and N. M. J. Woodhouse Integrability, self-duality and twistor theory (London Mathematical Society Monographs (New Series) No. 15, Clarendon Press, Oxford, 1996), x + 364pp., 0 19 853498 1, (hardback) £45. - Volume 41 Issue 1
Auxin molecular field maps define <scp>AUX</scp>1 selectivity: many auxin herbicides are not substrates (2017)

Developmental responses to auxin are regulated by facilitated uptake and efflux, but detailed molecular understanding of the carrier proteins is incomplete. We have used pharmacological tools to explore the chemical space that defines substrate preferences for the auxin uptake carrier AUX1. Total and partial loss-of-function aux1 mutants were assessed against wild-type for dose-dependent resistance to a range of auxins and analogues. We then developed an auxin accumulation assay with associated mathematical modelling to enumerate accurate IC<sub>50</sub> values for a small library of auxin analogues. The structure activity relationship data were analysed using molecular field analyses to create a pharmacophoric atlas of AUX1 substrates. The uptake carrier exhibits a very high level of selectivity towards small substrates including the natural indole-3-acetic acid, and the synthetic auxin 2,4-dichlorophenoxyacetic acid. No AUX1 activity was observed for herbicides based on benzoic acid (dicamba), pyridinyloxyacetic acid (triclopyr) or the 6-arylpicolinates (halauxifen), and very low affinity was found for picolinic acid-based auxins (picloram) and quinolinecarboxylic acids (quinclorac). The atlas demonstrates why some widely used auxin herbicides are not, or are very poor substrates. We list molecular descriptors for AUX1 substrates and discuss our findings in terms of herbicide resistance management.
Immunological survey of babesiosis (<i>Babesia peircei</i>) and toxoplasmosis in Jackass penguins in South Africa (1996)

Babesia peircei was extracted from nucleated erythrocytes of naturally infected Jackass penguin (Spheniscus demersus) from South Africa (SA). Babesia peircei glycoprotein-enriched fractions were obtained by concanavalin A-Sepharose affinity column chromatography and separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). At least 14 protein bands (9, 11, 13, 20, 22, 23, 24, 43, 62, 90, 120, 204, and 205 kDa) were observed, with the major protein at 25 kDa. Blood samples of 191 adult S. demersus were tested by enzyme-linked immunosorbent assay (ELISA) utilizing B. peircei glycoprotein-enriched fractions to detect anti-B. peircei IgG. The samples originated from three groups of free-ranging penguins (n = 110), 1 group of penguins (n = 66) which were rescued after offsh ore oil-spill contaminations and rehabilitated at the South African National Foundation for the Conservation of Coastal Birds (SANCCOB), and the final group from SANCCOB-resident penguins (n = 15). The overall B. peircei seroprevalence was 65 %, and the mean seropositive ranged from 60 to 71 % among the five penguin groups. The ELISA appeared to be specific for B. peircei IgG as tested against Haemoproteus columbae IgG and avian malaria (Plasmodium relictum, and P. elongatum) IgG. Toxoplasma gondii antibody (Ab) were detected by the direct agglutination test using killed T. gondii tachyzoites. All birds were seronegative for T. gondii Ab. The lack of T. gondii-positive penguins was due to the appropriate sanitary conditions and anti- Toxoplasma prevention procedures utilized by the SANCCOB.
Processing of ethanol fermentation broths by <i>Candida krusei</i> to separate bioethanol by pervaporation using silicone rubber‐coated silicalite membranes (2009)

Abstract BACKGROUND: Pervaporation employing ethanol‐permselective silicalite membranes as an alternative to distillation is a promising approach for refining low‐concentration bioethanol solutions. However, to make the separation process practicable, it is extremely important to avoid the problems caused by the adsorption of succinate on the membrane during the separation process. In this work, the pervaporation of an ethanol fermentation broth without succinate was investigated, as well as the influence of several fermentation broth nutrient components. RESULTS: Candida krusei IA‐1 produces an extremely low level of succinate. The decrease in permeate ethanol concentration through a silicone rubber‐coated silicalite membrane during the separation of low‐succinate C. krusei IA‐1 fermentation broth was significantly improved when compared with that obtained using Saccharomyces cerevisiae broth. By treating the fermentation broth with activated carbon, bioethanol was concentrated as efficiently as with binary mixtures of ethanol/water. The total flux was improved upto 56% of that obtained from the separation of binary mixtures, compared with 43% before the addition of activated carbon. Nutrients such as peptone, yeast extract and corn steep liquor had a negative effect on pervaporation, but this response was distinct from that caused by succinate. CONCLUSION: For consistent separation of bioethanol from C. krusei IA‐1 fermentation broth by pervaporation, it is useful to treat the low nutrient broth with activated carbon. To further improve pervaporation performance, it will be necessary to suppress the accumulation of glycerol. Copyright © 2009 Society of Chemical Industry
Abstract 1218: PTPRO as a candidate phosphatase in regulating EGFR signaling in colorectal cancer (2012)

Abstract Background Protein tyrosine phosphatases (PTPs) are known to be responsible for the negative regulation of many receptor tyrosine kinases by serving as antagonists to tyrosine kinase signaling. Several PTPs have been identified as candidate regulators of EGFR phosphorylation such as PTP1B, RPTP-sigma, RPTP-kappa, and PTPRJ (DEP-1). Here, we focused on PTPRO, a member of R3 family. The Drosophila ortholog of this family, Ptp4E/Ptp10D, negatively regulates EGFR signalling. Gene expression analysis of 688 primary tumours led us to identify PTPRO as a gene with strongly reduced expression in colorectal cancers with poor prognosis in particular the ones belonging to the Braf mutant subgroup. This suggests that PTPRO could act as a tumour suppressor by negative regulation of EGFR in colorectal cancer. Material and methods HEK293 cells were transiently transfected with wild-type (WT) PTPRO and with its catalytic mutant (C/S) and stimulated with EGF. After cell lysis, extracts were analyzed by SDS-PAGE and probed by western blotting with an anti-phosphotyrosine antibody (pY99, 4G10). The total level of EGFR is detected with anti-EGFR antibody. EGFR phosphorylation antibody arrays are used to identify the specific tyrosine phosphorylation sites. Results and discussion Upon expression of the PTPRO (C/S) mutant, we observe a delay in EGF induced EGFR degradation. Our preliminary data suggests that PTPRO might play a role in EGFR trafficking through the endocytic pathway and its catalytic activity is required for efficient endocytic progression of EGFR. Ongoing experiments will answer to this question. WT-PTPRO over-expression specifically decreases the Tyr 845 phosphorylation of EGFR, a known Src family tyrosine kinase (SFK) phosphorylation site. SFKs also regulate receptor turnover both at the level of endocytosis and cbl-mediated ubiquitination by phosphorylation. However, underlying mechanism how PTPRO can modulate EGFR signalling through the regulation of endocytic machinery is not known yet. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1218. doi:1538-7445.AM2012-1218