gebhart/patrepeval huggingface dataset:
贫血与脑损伤：问题多，答案少 (2009)

大量临床研究显示围手术期患者的脑损伤与急性贫血有关。这种损伤发生在接近于我们普遍认同的输血指征[血红蛋白（Hb）浓度7～8g/dl]，但高于脑组织缺氧的血红蛋白浓度（Hb3～4g／dl）的情况下。但是，贫血引起脑损伤的缺氧和非缺氧机制仍不清楚。此外，能最大程度降低急性贫血所致脑损伤的保护性机制仍未阐明。包括一氧化氮（NO）在内的血管扩张机制，在贫血时有助于维持大脑氧供，在各种急性稀释性缺血试验模型中，3种NO合成酶（NOS）（神经型、内皮型及可诱导型NOS）都有上调。近来的实验也证实了在相当于临床缺氧Hb浓度（Hb6—7g/dl）的啮齿类动物的大脑皮质中，重要的转录因子如缺氧诱导因子（HIF）-1α有所增加。这说明急性贫血对脑氧的供需平衡可能造成威胁，在缺氧的情况下，细胞浆中的HIF-1α降解被抑制，HIF-1α积聚成二聚体，移位到细胞核中并增加许多低氧分子的转录。这些低氧分子在贫血的脑组织中的表达也被发现上调，包括红细胞生成素，血管内皮生长因子，可诱导型NOS。此外，非低氧介质，包括细胞因子和血管激素，可以增加HIF-1α的转录。而且，源于NOS的NO也可以在没有组织缺氧时稳定HIF—1α。因此，在贫血时，HIF-1α在低氧和常氧情况下能对脑细胞进行调节。实验研究发现，针对不同类型的细胞，上调的HIF-1α可以表现为神经保护作用或神经毒性作用。在本综述中，我们描述了这些细胞作用过程，对贫血引起的脑损伤和保护机制有了更清晰的认识。贫血引起损伤的可能机制包括脑栓塞、组织缺氧、炎症、活性氧和兴奋性毒性。可能的细胞保护机制包括NOS／NO依赖的细胞氧供增强和包括HIF-1α、红细胞生成素及血管内皮生长因子在内的细胞保护机制。这些激活的细胞机制的总体平衡决定着它们在贫血时的�
Simple Regression Methods for Survival Time Studies (1973)

Abstract Given a set of grouped survival data, least squares estimates are proposed for the parameters of four survival distributions that can be fit: exponential, linear hazard, Gompertz and Weibull. Sample estimates of the hazard function are utilized in the least squares procedures and a method is given for selecting a distribution for further investigation based on the likelihood under the four survival models. A Monte Carlo study demonstrated that the least squares estimates are nearly as efficient as maximum likelihood when the sample size is 50 or more. The methods are applied to survival data for 112 patients with plasma cell myeloma.
Psychopathological Syndromes of Schizophrenia: Evaluation of the Dimensional Structure of the Positive and Negative Syndrome Scale (2000)

The Positive and Negative Syndrome Scale (PANSS) was originally designed as a rating system that provides balanced representation of positive and negative symptom features. Evidence from recent factor-analytic studies suggests that a five-dimensional solution appears to best fit the psychopathological data as assessed with the PANSS. To investigate the dimensional structure, we administered the PANSS to 253 inpatients with schizophrenia. In accordance with former studies, principal components analyses yielded five orthogonal dimensions: hostile excitement; negative, cognitive, and positive syndrome; and depression. When compared with questionnaires measuring subjective nonpsychotic experiences of schizophrenia, paranoid mood, and depression, the correlation pattern verifies the PANSS components. In addition, we investigated a subsample of 70 male patients with a Continuous Performance Test (CPT), a Span of Apprehension Task, and a Modality Shift Effect (MSE) paradigm; the CPT was significantly associated with the cognitive syndrome, and the MSE correlated with the negative syndrome.
The Planet, 2001, Spring (2001)

https://cedar.wwu.edu/planet/1031/thumbnail.jpg
Application of Fungicides Alternatives as Seed Treatment for Controlling Root Rot of Some Vegetables in Pot Experiments (2012)

Different root rot fungi, <i>Alternaria solani Fusarium solani, F. oxysporum, Rhizoctonia solani, Sclerotium rolfsii, Macrophomina phaseolina </i>and<i> Pythium </i>sp<i>.</i> were isolated from various vegetables, <i>i.e</i>. Cucumber, Cantaloupe, Tomato and Pepper grown in plastic houses under protected cultivation system and showing root rot and or damping-off disease symptoms. The tested antagonistic fungi were <i>Trichoderma</i> <i>harzianum</i>, <i>T</i>. <i>Viride </i>and<i> T. hamatum, </i><i>B</i><i>acillus</i><i> subtilis, P</i><i>se</i><i>u</i><i>domonas</i><i> </i><i>fluorescens</i> and <i>S</i><i>accha</i><i>romyces</i><i> </i><i>cerevisiae</i>. The efficacy of Calcium chloride, Thyme oil and /or bio-agents as seed dressing against disease incidence was evaluated in pot experiments under artificially infested with vegetables root rot causal organisms under greenhouse conditions. All applied treatments reduced significantly root rot incidence at both pre-, and post-emergence growth stages of Cucumber, Cantaloupe, Tomato and Pepper plants comparing with untreated check control. The obtained results showed that combination treatments of Calcium chloride, Thyme oil with bio-agents reduced significantly root rot incidence of all grown vegetables comparing with the application of each of them alone. Obtained results, in the present study, lead to suggest that integration between salt or essential oil and bio-agents is considered an applicable, safe and cost-effective method for controlling such soil-borne diseases.
Smith-Petersen Vitallium mould arthroplasty (2011)

A variety of materials were used for early hip prostheses. The introduction of Vitallium by Smith-Petersen represented a further advance in this surgical field. We present the longest known follow-up of a Smith-Petersen Vitallium mould arthroplasty.
Frequency Domain Electromagnetic Sensor Array Development (2007)

A laboratory prototype frequency domain electromagnetic induction sensor array suitable for simultaneous operation with an array of cesium vapor total field magnetometers has been designed and fabricated and has undergone limited bench testing. The design is based on the GEM-3 active primary field cancellation technology, which creates a "magnetic cavity" for each receive coil in the array. The array's magnetometers would be mounted inside the receive coils, within the magnetic cavities. This is very important because the primary transmit field would otherwise be strong enough to shift the total magnetic field vector (static magnetic field plus EMI components) outside the operating envelope of the magnetometers. Because the array configuration does not have the symmetry of a standard GEM-3, in-phase drift tends to be more severe. Tests with the prototype array show drift rates roughly one order of magnitude larger than with a standard GEM-3. However, demedian filtering such as that used for the MM-0033 towed GEM-3 array can correct for the drift. The most serious issue for the array is structural rigidity. When the array is bent, the bucking coils do not properly cancel the field from the outer transmit loop. Calculations indicate that bucking errors amounting l0's of ppm can be caused by bending the array by a few tenths of a degree over a distance of about 30 cm. The array would have to be held stiff to this sort of tolerance. For towed applications on land this may be difficult because the array will be subjected to significant bending stresses as it is towed over any realistic terrain. The bouncing and jostling motions for vehicle towed systems tend to have scales comparable to those of buried UXO signals. The situation may not be so serious for marine applications where the array would be buoyed up and not subject to such severe stresses.
Unsupervised key-phrases extraction from scientific papers using domain and linguistic knowledge (2008)

The domain of Digital Libraries presents specific challenges for unsupervised information extraction to support both the automatic classification of documents and the enhancement of userspsila navigation in the digital content. In this paper, we propose a combined use of machine learning techniques (i.e. Support Vector Machines) and Natural Language Processing techniques (i.e. Stanford NLP parser) to tackle the problem of unsupervised key-phrases extraction from scientific papers. The proposed method strongly depends on the robust structural properties of a scientific paper as well as on the lexical knowledge that we are able to mine from its text. For the experimental assessment we have use a subset of ACM papers in the Computer Science domain containing 400 documents. Preliminary evaluation of the approach shows promising result that improves - on the same data-set - on state-of-the-art Bayesian learning system KEA from a minimum 27% to a maximum 77% depending on KEA parameters tuning and specific evaluation set. Our assessment is performed by comparison with key-phrases assigned by human experts in the specific domain and freely available through ACM portal.
Acceptance of Ubiquitous Computing (2005)

Abstract With portability similar to a spiral notebook, the tablet PC enables new ways of working. This study investigates user acceptance of this new technology through interviews with employees in four industries who participated in three-month trials.
Coloquio sobre la interpretación del Convenio de Bruselas por el Tribunal de Justicia de las Comunidades Europeas en la perspectiva del espacio judicial europeo (1991)

Our results demonstrate that the cardioprotective effect of polydatin against hyperglycemia-induced myocardial injury is mediated by inhibition of NADPH oxidase and NF-κB activity. The findings may provide a novel understanding the mechanisms of the polydatin to be a potential treatment of diabetic cardiomyopathy.
Integrated Avionics System (IAS): Integrating 3D Technology on a Spacecraft Panel (2003)

As spacecraft designs converge toward miniaturization, and with the volumetric and mass challenges placed on avionics, programs will continue to advance the “state of the art” in spacecraft system development with new challenges to reduce power, mass and volume. Traditionally, the trend is to focus on high-density component packaging technologies. Industry has made significant progress in these technologies, and other related internal and external interconnection schemes. Although new technologies have improved packaging densities, a system packaging architecture is required that not only reduces spacecraft volume and mass budgets, but increase integration efficiencies, provide modularity and flexibility to accommodate multiple missions while maintaining a low recurring cost. With these challenges in mind, a novel system packaging approach incorporates solutions that provide broader environmental applications, more flexible system interconnectivity, scalability, and simplified assembly test and integration schemes. The Integrated Avionics System (IAS) provides for a low-mass, modular distributed or centralized packaging architecture which combines ridged-flex technologies, high-density COTS hardware and a new 3-D mechanical packaging approach, Horizontal Mounted Cube (HMC). This paper will describe the fundamental elements of the IAS, HMC hardware design, system integration and environmental test results.
Abstract 4078: Over-expression of FOXM1 is associated with cell migration/invasion in ovarian cancer (2010)

Abstract FOXM1 is a typical transcription factor regulating the S- and M-phase progression in cell cycle. It is frequently over-expressed and is associated with tumor stages in numerous human cancers. The influence of FOXM1 expression on cell proliferation has been well studied, yet its impact on other tumor characteristics in ovarian cancer, like cell migration/invasion remains unclear. In the present study, we demonstrated that FOXM1 was significantly up-regulated in ovarian cancer cell lines at both RNA and protein level by semi-quantitative RT- PCR and Western blot analyses. Immunohistochemical analysis showed that FOXM1 was highly correlated with the high-grade ovarian cancer. To examine the effect of FOXM1 on ovarian cancer cell motility, the FOXM1 specific inhibitor, thiostrepton, was used to reduce FOXM1 expression in OVCA433 cells. The FOXM1 reduced OVCA433 cells, as a result, showed a significant decrease in cell migration using wound healing assay. By using MEK specific inhibitor, U0126, we demonstrated that the inhibition of ERK activity caused a reduction of FOXM1 level in a time dependent manner and significant reduction of cell migration rate in the wound healing assay in OVCA433. In sum, FOXM1 is over-expressed and regulated by constitutive activated ERK activity in ovarian cancer cells. Our data also suggested that the ERK /FOXM1 signaling axis is crucial in regulating migration/invasion of ovarian cancer cells. Further studies on the molecular mechanism of FOXM1 in the regulation of ovarian cancer cell migration/invasion are warranted. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4078.
Physico-chemical study of the focused electron beam induced deposition process (2005)

The focused electron beam induced deposition process is a promising technique for nano and micro patterning. Electrons can be focused in sub-angström dimensions, which allows atomic-scale resolution imaging, analysis, and processing techniques. Before the process can be used in controlled applications, the precise nature of the deposition mechanism must be described and modelled. The aim of this research work is to present a physical and chemical description of the focused electron beam induced deposition process. As an introduction, a review of the literature, up to the present day, shows how this process was first identified as the origin of contamination in electron microscopes. Then the modifications made to a scanning electron microscope for deposition experiments are described. Gas supply systems and gas cryo-trapping devices were set up. Electrical and optical systems were constructed for an in-situ monitoring of the process. The experiment procedure was carried out in several phases, with the first being the deposition of flat films of carbon, copper-containing carbon composites, and pure gold for the study of the physics of the process. By measuring the fraction of the probe current that was absorbed in the sample, an accurate description could be made of the propagation of electrons. The backscattered electrons clearly influenced the deposition rate of Cu-containing films. A physical model for scanning deposition was created. The second phase is the deposition of metal-matrix composite tips from a stationary beam. Forward electron scattering was discovered to be responsible for tip formation and shape. A physical model of electron trajectories is included. The third phase is the construction of three-dimensional micro-structures by moving the beam during deposition. The deposited shapes result from an electron range that is larger than the structure size. Further investigation into the chemistry of the process involved the analysis of carbon films by micro-beam techniques. Regardless of the precursor used, the resulting films had a composition as C9H2±xO1±x (x<1). The C phase hybridization was 90% sp2. The elements H, N, O, F, and Cl were volatilized from the precursor during precursor fixation. Further parameters of deposition rate, temperature of the sample, vapour pressure, and the dipole moment of the precursors were examined. Electrically conductive metal-containing focused electron beam induced deposits were used for constructing micro-devices, a nanotube-based contact and a magnetic field sensor with 500 × 500 nm2 active area.
A new process of fabricating electrically conducting nylon 6/graphite nanocomposites via intercalation polymerization (2000)

A new process was developed to fabricate electrically conducting nylon 6/graphite nanocomposites via intercalation polymerization of ϵ-caprolactam in the presence of expanded graphite. The transition from an electrical insulator to an electrical semiconductor for nylon 6 occurred when the graphite volume content was 0.75, which was much lower than that of conventional conducting polymer composites. The electrical conductivity reached 10−4 S/cm when the graphite content was 2.0 vol %. The TEM microphotographs suggested that the low percolation threshold and the great improvement of electrical conductivity could be attributed to the high aspect ratio (width-to-thickness), the high expansion ratio in c axis of the graphite sheets and the homogeneous dispersion of the nanoscale graphite particles in the nylon 6 matrix. © 2000 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 38: 1626–1633, 2000
Studies on the Effect of Starvation on Mycobacteria (1974)

Ten cultures of Mycobacterium tuberculosis, one of Mycobacterium kansasii (nonsignificant), and one of Mycobacterium phlei were submitted to starvation. As a result they lost first their acid fastness and then all other staining affinities but, in this chromophobic state, they survived for at least 2 years and, after that time, produced cultures of acid-fast bacilli when transferred onto nutrient media. Chromophobic tubercle bacilli similar to those produced experimentally had previously been demonstrated in caseous lesions of lungs surgically removed from patients under chemotherapy. Since it has been shown that experimentally produced chromophobic bacilli can recover their original biological properties, the opinion is warranted that, under suitable conditions, those in the lung could also become reactivated and cause a relapse of the disease.
Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7–36)-Amide (1989)

We examined the effect of glucagonlike peptides (GLPs), which are cleaved from preproglucagon in the enteroglucagon cells, on rat endocrine pancreas with the isolated perfused system. GLP-I-(7-36)-amide, a truncated form of full-sequence GLP-I-(1-37), showed a potent inhibitory effect on glucagon secretion. This inhibitory effect of GLP-I-(7-36)-amide was demonstrated at concentrations of 0.25, 2.5, and 25 nM in 11.2 and 2.8 mM glucose. In contrast, insulin release was significantly stimulated by GLP-I-(7-36)-amide at its concentration from 0.025 to 25 nM in a high glucose concentration, whereas in a low glucose concentration, the stimulation was seen only at the highest concentration (25 nM). Neither GLP-I-(1-37) nor GLP-II showed any effect on glucagon and insulin release. Although several gastrointestinal hormones have been nominated as incretins, none of them may suppress the glucagon secretion. A truncated form of GLP-I, GLP-I-(7-36)-amide thus seems to be a unique incretin that exerts glucagonostatic action.
Performance of a parallel algorithm for standard cell placement on the Intel hypercube (1987)

In this paper, we present a parallel simulated annealing algorithm for standard cell placement that is targeted to run on the Intel Hypercube. We present a novel tree broadcasting strategy that is used extensively in our algorithm for updating cell locations in the parallel environment. Studies on the performance of our algorithm on example industrial circuits show that it is faster and gives better final placement results than the uniprocessor simulated annealing algorithms.
Rapid and simple purification of T7 RNA polymerase (1991)

Journal Article Rapid and simple purification of T7 RNA polymerase Get access Volker Zawadzki, Volker Zawadzki Institut für Biochemie, Bayerische Julius-Maximilians-UniversitätRöntgenring 11, D-8700 Würzburg, FRG Search for other works by this author on: Oxford Academic PubMed Google Scholar Hans J. Gross Hans J. Gross Institut für Biochemie, Bayerische Julius-Maximilians-UniversitätRöntgenring 11, D-8700 Würzburg, FRG Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 8, 25 April 1991, Page 1948, https://doi.org/10.1093/nar/19.8.1948 Published: 25 April 1991 Article history Received: 22 February 1991 Published: 25 April 1991
Hydrodynamic and optical properties of the wheat germ E<sub>m</sub> protein (1985)

The size and shape of the E m protein from wheat embryos have been examined by gel filtration, densitometry, ultracentrifugation, and viscosity. Circular dichroism and fluorescence measurements have also been made. E m has an intrinsic sedimentation coefficient, [Formula: see text], of 1.11S and a Stokes radius, R S , of 28.2 Å (1 Å = 0.1 nm) as determined by high performance liquid chromatography gel filtration on a TSK 2000SW column. The partial specific volume [Formula: see text] from density measurements is 0.683 mL/g, a much lower than typical value. The molecular weight from sedimentation equilibrium is 11 200, with no indication for protein aggregation. The intrinsic viscosity [η] of E m is 6.02 mL/g. Circular dichroism shows the molecule to be about 70% random coil. The fluorescence emission spectrum is typical for a tyrosine-containing protein. The hydrodynamic data indicates a poor fit to either a prolate or oblate ellipsoid model; excess hydration or flexibility of the polypeptide chain caused by the rather unusual amino acid composition may be a possible cause. The implications that the low value of [Formula: see text], the high value of R S , and the random-coil configuration of the E m protein may have on its ability to bind water and to contribute to the maintenance of a minimal level of hydration compatible with the sustained viability of the "dry" organism are subjects of an extended discussion. Briefly, it is suggested that E m may provide a matrix of bound water which opposes denaturation of proteins in the "desiccated" cytoplasm of dry plant embryos.
Siamese Keypoint Prediction Network for Visual Object Tracking (2020)

Visual object tracking aims to estimate the location of an arbitrary target in a video sequence given its initial bounding box. By utilizing offline feature learning, the siamese paradigm has recently been the leading framework for high performance tracking. However, current existing siamese trackers either heavily rely on complicated anchor-based detection networks or lack the ability to resist to distractors. In this paper, we propose the Siamese keypoint prediction network (SiamKPN) to address these challenges. Upon a Siamese backbone for feature embedding, SiamKPN benefits from a cascade heatmap strategy for coarse-to-fine prediction modeling. In particular, the strategy is implemented by sequentially shrinking the coverage of the label heatmap along the cascade to apply loose-to-strict intermediate supervisions. During inference, we find the predicted heatmaps of successive stages to be gradually concentrated to the target and reduced to the distractors. SiamKPN performs well against state-of-the-art trackers for visual object tracking on four benchmark datasets including OTB-100, VOT2018, LaSOT and GOT-10k, while running at real-time speed.
Fc Receptor(s) Induced by Human Cytomegalovirus Bind Differentially with Human Immunoglobulin G Subclasses (1986)

The IgG subclass specificity of Fc receptor(s) induced on cells by infection with human cytomegalovirus (HCMV) was studied in a binding assay by using infected cells and purified iodinated IgG of various subclasses from HCMV seronegative healthy adult donors. All four human IgG subclasses bound to HCMV-infected cells, with the following relative magnitudes: IgG1 greater than or equal to IgG4 greater than IgG2 greater than IgG3. The IgG subclass specificity of the Fc receptor was further analysed in an inhibition assay by using fragments prepared from purified human IgG by papain digestion, and using unlabelled subclass proteins. Fc but not Fab fragments inhibited the binding of 125I-labelled human IgG to HCMV-infected cells. The biological role of the Fc receptor in HCMV infection is discussed.
Quantum Chemistry Can Locally Improve Protein Crystal Structures (2003)

We have re-refined the X-ray structure of the heme site in cytochrome c553, supplementing the crystallographic data with quantum chemical geometry optimizations, instead of the molecular mechanics force field used in standard crystallographic refinement. By comparing the resulting structure, obtained using medium-resolution data (170 pm), with an atomic-resolution structure (95 pm) of the same protein, we show that the inclusion of quantum chemical information into the refinement procedure improves the structure significantly. Thus, errors in the Fe-ligand distances are reduced from 3 to 32 pm in the low-resolution structure to 0-5 pm in the re-refined structure, one side-chain atom changes its conformation (a movement by 214 pm toward its position in the high-resolution structure), and the R factors are improved by up to 0.018. Thus, quantum refinement may be a powerful method to obtain an accurate structure for interesting parts of a protein.