gebhart/patrepeval huggingface dataset:
Loss of Protein Kinase C‐αβ in Brain of Heroin Addicts and Morphine‐Dependent Rats (1995)

The biochemical status of human brain protein kinase C (PKC)-alpha beta during opiate dependence was studied by means of immunoblotting techniques in postmortem brain of heroin addicts who had died by opiate overdose. In the frontal cortex, a marked decrease (53%, p < 0.05) in the immunoreactivity of PKC-alpha beta was found in heroin addicts compared with matched controls. The loss of PKC-alpha beta in the brain of human addicts paralleled that observed in the frontal cortex of rats after chronic treatment with morphine (10-100 mg/kg i.p. for 5 days) (PKC-alpha beta decreased by 34%, p < 0.05). Chronic treatment with naloxone (1 mg/kg i.p. every 12 h for 5 days) did not alter PKC-alpha beta immunoreactivity in the rat brain. However, in morphine-dependent rats, naloxone-precipitated withdrawal induced a rapid and strong behavioral reaction with a concomitant up-regulation of PKC-alpha beta immunoreactivity to control values. These results indicated that the decrease of brain PKC-alpha beta induced by heroin/morphine is a mu-opioid receptor-mediated effect. The chronic administration of opiates has been associated with a marked sensitization of the adenylyl cyclase/cyclic AMP system, although this phenomenon is not exclusive of the opioid system but the general cellular adaptation to chronic inhibition of adenylyl cyclase. In this context, chronic treatment of rats with other inhibitory agonists (e.g., clonidine, 1 mg/kg i.p. every 12 h for 14 days) acting through receptors (e.g., alpha 2-adrenoceptors) also coupled to adenylyl cyclase did not alter brain PKC-alpha beta immunoreactivity.(ABSTRACT TRUNCATED AT 250 WORDS)
Synthetic Studies on a Nonsteroidal Progesterone Metabolite: Regioselective N-Alkylation of an Activated Pyrazole (2010)

This paper describes the large-scale synthesis of a progesterone receptor metabolite. The key step in this sequence was the regioselective pyrazole N-alkylation.
Structural and Antigenic Properties of Merozoite Surface Protein 4 of <i>Plasmodium falciparum</i> (1999)

Merozoite surface protein 4 (MSP4) of Plasmodium falciparum is a glycosylphosphatidylinositol-anchored integral membrane protein of 272 residues that possesses a single epidermal growth factor (EGF)-like domain near the carboxyl terminus. We have expressed both full-length MSP4 and a number of fragments in Escherichia coli and have used these recombinant proteins to raise experimental antisera. All recombinant proteins elicited specific antibodies that reacted with parasite-derived MSP4 by immunoblotting. Antibody reactivity was highly dependent on the protein conformation. For example, reduction and alkylation of MSP4 almost completely abolished the reactivity of several antibody preparations, including specificities directed to regions of the protein that do not contain cysteine residues and are far removed from the cysteine-containing EGF-like domain. This indicated the presence of conformation-dependent epitopes in MSP4 and demonstrated that proper folding of the EGF-like domain influenced the antigenicity of the entire molecule. The recombinant proteins were used to map epitopes recognized by individuals living in areas where malaria is endemic, and at least four distinct regions are naturally antigenic during infection. Binding of human antibodies to the EGF-like domain was essentially abrogated after reduction of the recombinant protein, indicating the recognition of conformational epitopes by the human immune responses. This observation led us to examine the importance of conformation dependence in responses to other integral membrane proteins of asexual stages. We analyzed the natural immune responses to a subset of these antigens and demonstrated that there is diminished reactivity to several antigens after reduction. These studies demonstrate the importance of reduction-sensitive structures in the maintenance of the antigenicity of several asexual-stage antigens and in particular the importance of the EGF-like domain in the antigenicity of MSP4.
Proposal of a New Risk Score for Patients Treated with Transarterial Chemoembolization due to Recurrent Hepatocellular Carcinoma after Curative Resection: A Multicenter Study (2019)

A new pHAP score optimized for patients treated with TACE due to recurrent HCC after resection showed acceptable accuracy and was externally validated. Further studies of means by which to select treatment options other than TACE for high-risk patients according to pHAP scores are warranted.
The Action of Primary Grignard Reagents with t-Butylacetyl Chloride. II<sup>1</sup> (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Action of Primary Grignard Reagents with t-Butylacetyl Chloride. II1Frank C. Whitmore, J. S. Whitaker, K. F. Mattil, and A. H. PopkinCite this: J. Am. Chem. Soc. 1938, 60, 11, 2790–2792Publication Date (Print):November 1, 1938Publication History Published online1 May 2002Published inissue 1 November 1938https://pubs.acs.org/doi/10.1021/ja01278a070https://doi.org/10.1021/ja01278a070research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Total Syntheses of Useful Bioactive Compounds and Significance of Their Developents (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Coupling CFD with Vibroacoustic FE Models for Vehicle Interior Low-Frequency Wind Noise Prediction (2015)

<div class="section abstract"><div class="htmlview paragraph">With the reduction of engine and road noise, wind has become an important source of interior noise when cruising at highway speed. The challenges of weight reduction, performance improvement and reduced development time call for stronger support of the development process by numerical methods. Computational Fluid Dynamics (CFD) and finite element (FE) vibroacoustic computations have reached a level of maturity that makes it possible and meaningful to combine these methods for wind noise prediction.</div><div class="htmlview paragraph">This paper presents a method used for coupling time domain CFD computations with a finite element vibroacoustic model of a vehicle for the prediction of low-frequency wind noise below 500 Hz. The procedure is based on time segmentation of the excitation load and transformation into the frequency domain for the vibroacoustic computations. It requires simple signal processing and preserves the random character as well as the spatial correlation of the excitation signal. The aeroacoustic load is applied on the entire outer surface of the vehicle body. The computed results are validated against wind tunnel measurements on a production vehicle. The numerical and experimental investigations provide some insight into the mechanisms involved in underbody wind noise.</div></div>
Réglementation des systèmes financiers et croissance économique dans les pays de l'OCDE (2008)

Le fonctionnement du système financier peut avoir un impact décisif sur la croissance économique et sur la stabilité de l’économie. Il influe sur la croissance économique à long terme par son effet sur l’efficience de l’intermédiation entre épargnants et emprunteurs finaux ; par le degré auquel il permet une surveillance des utilisateurs de fonds externes, ce qui se répercute sur la productivité du capital utilisé ; enfin, par son incidence sur le volume de l’épargne, qui conditionne la capacité future de l’économie de générer des revenus. Le système financier agit sur la stabilité de l’économie en raison du fort pouvoir de levier de ses activités et de son rôle central dans le règlement de l’ensemble des transactions au sein de l’économie, de sorte que toute défaillance d’un segment risque de compromettre la stabilité du système dans son ensemble.
Highly efficient THz modulation using optically excited silicon (2005)

Optically controlled modulation of broadband THz radiation with a comparably uniform spatial distribution is demonstrated in a Si-based semiconductor structure with moderate doping. Using THz Time-Domain Spectroscopy a maximum intensity modulation of more than 99% was demonstrated for a spectrum ranging from 50GHz to 3.5THz with 3dB attenuation already for optical excitation as low as only 5mW. The uniformity of the modulation was measured and compared to the THz beam profile.
ChemInform Abstract: Oxidation of Chloride to Chlorine by Ce(IV) Ions Mediated by Different Ru(IV) and Ir(IV) Oxide‐Based Catalysts. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Scanning probe microscopies for analytical studies at the nanometer scale (2005)

Les microscopies locals de rastreig han transformat la manera d'estudiar l'estructura i les propietats d'una gran varietat de sistemes. Sens dubte, han tingut un paper essencial en moltes disciplines, com ara la fisica, la quimica, la biologia i l'enginyeria, i han contribuit al naixement de nous camps, com ara la nanociencia i la nanotecnologia. El present article intenta destacar la versatilitat i l'alta sensibilitat d'aquestes tecniques per tal de capturar informacio analitica a escala nanometrica. En aquest context, s'intentara examinar l'evolucio d'aquestes tecniques nanoscopiques des de la seva capacitat per a recollir informacio topografica, estructura atomicomolecular i processos dinamics in situ fins a determinar localment propietats fisiques i quimiques. Es presenta una seleccio d'estudis il·lustratius basats en aquestes tecniques que abraca diverses arees de la ciencia.
Mechanochemical Rhodium(III)‐ and Gold(I)‐Catalyzed C−H Bond Alkynylations of Indoles under Solventless Conditions in Mixer Mills (2018)

Abstract Mechanochemical activations in Rh III ‐ and Au I ‐catalyzed C−H alkynylations lead selectively to C 2 ‐ and C 3 ‐alkynylated indoles. The processes show excellent functional group tolerance, do not require additional heating and proceed under solventless conditions. Compared to solvent‐based standard protocols, the reaction times are shorter and the catalyst quantities lower resulting in high product yields under ambient atmosphere in mixer mills.
Interplay of Coronary Artery Calcification and Traditional Risk Factors for the Prediction of All-Cause Mortality in Asymptomatic Individuals (2012)

By highlighting that individuals without RFs but elevated CAC have a substantially higher event rates than those who have multiple RFs but no CAC, these findings challenge the exclusive use of traditional risk assessment algorithms for guiding the intensity of primary prevention therapies.
Protection against sexually transmitted diseases by granting sex workers in Thailand the choice of using the male or female condom (1998)

Results are available from 34 sex establishments (249 women) in the male/female condom group, and 37 sex establishments (255 women) in the male condom group. Condom use was very high in both groups (97.9 and 97.3 % of all sexual acts, respectively, P > 0.05). Male condom use was lower in the male/female condom group when compared with the male condom group (88.2 and 97.5%, respectively, P < 0.001). However, this reduction in male condom use was counterbalanced by the use of female condoms in 12.0% of all sexual acts in the male/female condom group, contributing to a 17% reduction in the proportion of unprotected sexual acts in this group when compared to the male condom group (5.9 versus 7.1%, respectively, P = 0.16). Female condom use was sustained over the entire study period. There was also a 24% reduction in the weighted geometric mean incidence rate of STDs in the sex establishments of the male/female condom group compared to the male condom group (2.81 versus 3.69 per 100 person-weeks, P = 0.18).
ChemInform Abstract: HIGHLY STEREOSELECTIVE CONVERSION OF PROSTAGLANDIN A2 TO THE 10,11ALPHA‐OXIDE DERIVATIVE USING A REMOTELY PLACED EXOGENOUS DIRCTING GROUP (1973)

Abstract Die aus den entsprechenden Prostaglandinen erhaltenen Si1yläther(Ia) und (Ib) werden beschrieben.
Retinotectal Specificity: Models and Experiments in Search of a Mapping Function (1980)

Embryonic development of nerve patterns has fascinated and frustrated neurobiologists for decades. The orderly connections within the central nervous system and between the central nervous system and peripheral end organs are thought to be formed by a number of different means ranging from selective cell death, through timing and mechanical guidance, to chemospecificity. A system that has gained great popularity for the study of topographic connections between sets of neurons is the retinotectal system of lower vertebrates (amphibia and fish). Although this system has hardly been cooperative in yielding conclusive evidence (Horder & Martin 1978, Hunt & Jacobson 1974), its great popularity has led to a mass of experimental data, which, by sheer bulk and ever more refined experimental design, has begun to crystallize into strong support and strong challenge to various proposed ideas for the assembly of connections between the eye and brain.
Preferences for Wastewater Management Programs in Rhode Island: Accounting for Shellfish, Drinking Water, and Strategic Behavior (2005)

This paper discusses resistance to wastewater management programs in coastal communities. Innovative stated preference survey responses are used to rank the importance of private onsite benefits, water quality protection, environmental perceptions, and treatment responsibility. Resistance becomes strategic when treatment responsibility is heterogeneous and environmental values compete with private onsite benefits.
Fever (2009)

Better markers are required to predict serious bacterial infection in a child with fever. Clinical application of the host immune response in the diagnosis and management of fever is the direction of the future.
Clinical Worsening in Reversible Cerebral Vasoconstriction Syndrome (2013)

Clinical worsening after diagnosis is common in patients with RCVS. Thus, RCVS is self-limited but not strictly monophasic. Most patients have a very favorable outcome, but clinical worsening may result in permanent deficits.
ChemInform Abstract: A Novel “One‐Pot” Synthesis of Thiosugar‐Derived S‐Xanthates. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parameter study on a finite element model of the middle ear / Parameterstudie an einem Finite-Elemente-Modell des Mittelohrs (2010)

Models of the middle ear basing on the finite element method (FEM) have contributed to a better understanding of the function of its different components. The geometry, the choice of boundary conditions and material properties have a crucial influence on the model. The influence of individual parameters was investigated. Based on a magnetic resonance imaging data set, a finite element model (FEm) of the middle ear was established. The transfer function (TF) at a sound pressure level of 90 dB and a frequency range from 100 Hz to 10 kHz was determined. Altogether, 24 parameters were varied individually and the influence on the TF was investigated. The parameter study was based on varying the stiffness and damping of each material as well as on anatomic variations, such as thickness and anisotropy of the tympanic membrane and sliding within the joints. It could be shown that each parameter had influence over the entire or sections of the frequency range in different magnitudes. A chart was derived to show the influence of each parameter depending on the frequency. The results allow improved distinguishing between parameters being relevant for a FEM simulation of the middle ear and those that can be neglected. This could contribute to further improvement of FEms of the middle ear.
Assessment of bleomycin, adriamycin and mitomycin‐C in the treatment of recurrent cervical cancer (1985)

Twenty women with recurrent squamous cell carcinoma of the cervix were treated with bleomycin followed by adriamycin and mitomycin-C. Treatment was repeated every 28 days. In 18 patients who could be assessed there was one complete response and five partial responses (response rate 33%). Two partial responses were seen in 13 lesions arising from previously irradiated sites of disease (response rate 23%). Three complete responses and three partial responses were observed in 10 lesions arising from non-previously irradiated sites of disease (response rate 60%). In all responding cases tumour regression was noted before the end of the third cycle of treatment. Toxicity was predictable and manageable. These results suggest that chemotherapy may be used as a cytoreductive procedure before radical local treatment.
Quantitative Analysis of Aldolase A mRNA in Liver Discriminates between Hepatocellular Carcinoma and Cirrhosis (2000)

The quantitative analysis of liver tissue aldolase A mRNA differentiates between nonneoplastic chronic liver diseases and hepatocellular carcinoma, which suggests that it has diagnostic potential.
Comparison of AlGaN/GaN MSM varactor diodes based on HFET and MOSHFET layer structures (2006)

In this comparative study we investigate the performance of AlGaN/GaN based MSM varactor diodes based on HFET and MOSHFET layer systems. Device fabrication uses standard HFET fabrication technology, allowing easy integration in MMICs. Devices with different electrode geometries are characterized by DC and by S-parameter measurements up to 50 GHz. The HFET based varactors show capacitance ratios up to 14. The MOSHFET based devices, on the other hand, exhibit lower capacitance ratios and poorer stability because of the insulation layer between electrodes and semiconductor.
Osteoarthritis – Why Exercise? (2013)

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. The etiology of OA is not clear, but common risk factors for developing OA include age, joint injury, mechanical overuse, and obesity.
An Introduction to Assessing Genomic Screening and Diagnostic Tests (2011)

In Brief This article describes a genomic test assessment framework for evaluating, interpreting, and reporting genomic data. The framework contains 5 components, the first of which requires that the medical disorder be specified, along with the test(s) used for detecting the disorder and the clinical setting in which testing is to be offered. Then, 4 aspects of test performance are examined: Analytic validity, Clinical validity, Clinical utility, and Ethical, legal, and social issues (abbreviated as ACCE). Each section contains specific questions that can be applied to a wide variety of genomic screening and diagnostic tests, including those that might be used for estimating risks for future health disorders. Assessing such tests systematically is especially important at present, because definitive studies are often unavailable to determine whether knowledge of specified genotypes will be more effective in improving health than knowledge gained from existing practice. Often, for example, a genotype that is shown to be a valid risk factor for a common problem such as heart disease will mistakenly be considered to have clinical utility when converted into a screening test. Understanding the performance characteristics of a genomic test is of special concern when it is advocated for widespread application, such as population-based screening, because of the potential for generating false expectations and wasting resources that might be better invested elsewhere. Although initially designed to provide policymakers with up-to-date and reliable information for decision making, the ACCE framework is user-friendly to individual health professionals, who can apply the questions to any test being promoted in their field to assess clinical validity and utility. Subsequent to preliminary applications in a feasibility study, aspects of this assessment framework have been incorporated into the methods of the Evaluation of Genomic Applications in Practice and Prevention Working Group, established by the Office of Public Health Genomics at the Centers for Disease Control and Prevention. The Evaluation of Genomic Applications in Practice and Prevention Working Group issues recommendations about the suitability of new genetic tests for use in everyday practice, based on commissioned evidence reviews, and serves as an added resource to health professionals Genetic tests have their strengths, but some have problems
La défense des palmeraies marocaines contre le bayoud (1934)

Célérier Jean. La défense des palmeraies marocaines contre le bayoud. In: Annales de Géographie, t. 43, n°245, 1934. pp. 559-560.
Books Reviewed (1958)

The engineer in industry has been accustomed to study problems assigned to him and to arrive at a functional design for their solution. More
<title>Ultrasensitive intracavity molecular spectroscopy for diagnostic applications</title> (1994)

Intracavity laser spectroscopy (ILS) presents itself as a highly effective technique that allows one to detect the change of light signal from absorbing molecules at a level of radiation quantum noise. Thus high sensitivity of ICLS allows one to determine the absorbing molecules concentrations in gases and liquids in the range between 10<SUP>-6</SUP> to 10<SUP>-10</SUP>. The potential of ICLS technique employment for establishing interrelations between small changes in the breathed air caused by diseases in the early stage, as well as a mass screening of patients with diseases of the liver and kidneys by acetone and urea detection in breathed air, and with heart diseases by measurement of CO<SUB>2</SUB> concentration is discussed. Usage of gas, dye and solid-state lasers for such measurements is analyzed, optimum spectral ranges are presented.
DEVELOPMENT OF A PROGRAM FOR DYNAMIC RESPONSE SIMULATION OF A FLOATING BRDIGE SUBJECTED TO BOTH WINDS AND WAVES (2006)

浮体橋の設計においては，特に波と風による動的応答を正確に予測することが重要となるが，本研究ではこれらを同時に受ける場合の浮体橋の動的応答シミュレーションプログラムの開発をおこなった．ここでは特に分離ポンツーン型浮体橋を対象として，1)橋体部の弾性変形，2)ラディエーション流体力のメモリー効果，3)係留系における非線形反力特性，を同時に考慮できるものとした．また，波が橋軸に対し斜め入射する場合にも対応するため，各ポンツーンに作用するディフラクション波力間の位相差を考慮できるものとした．開発されたプログラムを検証するため，別途実施された風洞内水槽での弾性浮体橋モデルに対する実験結果との比較をおこない，本プログラムによる解析値と実験値が良好に一致することを確認した．