gebhart/patrepeval huggingface dataset:
Requirements analysis of differential GPS for Singapore (2002)

The use of GPS system is gradually and steadily increasing throughout the world. The degraded performance of the commercial/civilian GPS system due to the incorporation of selective availability (SA) feature of the system has provided significant impetus to the utilization of the concept of differential GPS. Successful implementations of the DGPS concept for non-military applications have been analyzed, designed and tested. Currently, emphasis is directed towards reducing the complexity and expense of the operational DGPS system for large areas such as the United States by the application of WADGPS (wide area DGPS). The goal of the research reported in this paper is to determine if a similar SADGPS (small area DGPS) implementation is possible for small nations like Singapore. Specifically, the approach to define constant GPS position corrections for commercial GPS receivers has been investigated The results indicate that such a simple model may be feasible for simple applications and more elaborate formulations may be needed to model general DGPS implementation. The results reported also indicate that the simple DGPS model will have to be a function of the equipment category.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rett syndrome: an eye‐tracking study of attention and recognition memory (2013)

This is one of the first studies to characterize attention and memory in individuals with Rett syndrome. Visually based techniques, such as the VPC, open a new avenue for quantifying the cognitive phenotype associated with this syndrome.
RTL - The firmware Design Automation system (1974)

The development of firmware controlled devices poses several new requirements on Design Automation. Because firmware is central to system design and reflects heavily on system speed and cost, the basic assembly parameters change after during the early design phases. It is necessary to have an automation system which is able to react to design changes without reprogramming of system components. Thus the standard approach of simulating firmware with a special purpose language and a special purpose assembler or assembler/simulator is no longer practical. This paper discusses a general solution to the several requirements of firmware design.
Functional Genomic Insights into Acute Lung Injury: Role of Ventilators and Mechanical Stress (2005)

Acute lung injury (ALI) is a complex and devastating illness, often occurring in the setting of sepsis and trauma. Despite recent advances in the understanding and treatment of ALI, pathogenic mechanisms and genetic modifiers in ALI remain incompletely understood. Furthermore, there has been increasing interest in the identification of genetic variations that contribute to ALI susceptibility and severity in order to gain unique insights into ALI pathogenesis and to design novel treatment strategies. However, the sporadic nature of ALI and the lack of family-based cohort studies preclude conventional genomic approaches such as linkage mapping (or "positional cloning"). We have used a "candidate gene approach" with extensive gene expression profiling studies in animal (rat, murine, canine) and human models of ALI to identify potential ALI candidate genes associated with sepsis and ventilator-associated lung injury. These studies, when combined with innovative in silico bioinformatics approaches, revealed both novel (pre--B-cell colony enhancing factor, myosin light chain kinase) and previously identified (interleukin 6, macrophage migration inhibitory factor) gene candidates. Subsequent single nucleotide polymorphism discovery and genotyping studies revealed polymorphisms that demonstrate an influence on ALI susceptibility in patients. These studies indicate that the candidate gene approach is a robust strategy to provide novel insights into the genetic basis of ALI, and the identification of potentially novel therapeutic targets.
Empirical low-field mobility model for III–V compounds applicable in device simulation codes (2000)

A Caughey–Thomas-like mobility model with temperature and composition dependent coefficients is used in this work to describe the dependence of electron and hole mobilities on temperature, doping concentration, and alloy composition. Appropriate parameter sets are given for a large number of III–V binary and ternary compounds, including: GaAs, InP, InAs, AlAs, GaP, Al0.3Ga0.7As, In0.52Al0.48As, In0.53Ga0.47As, and In0.49Ga0.51P. Additionally, physically justifiable interpolation schemes are suggested to find the mobilities of various ternary and quaternary compounds (such as AlxGa1−xAs, In1−xGaxP, In1−xGaxAs, In1−xAlxAs, and In1−xGaxAsyP1−y) in the entire range of composition. The models are compared with numerous measured Hall data in the literature and very good agreement is observed. The limitations of the present model are also discussed. The results of this work should be extremely useful in device simulation packages, which are currently lacking a reliable mobility model for the above materials.
The experience factory: strategy and practice (1995)

The quality movement, that has had in recent years a dramatic impact on all industrial sectors, has recently reached the system and software industry. Although some concepts of quality management, originally developed for other product types, can be applied to software, its specificity as a product which is developed and not produced requires a special approach. This paper introduces a quality paradigm specifically tailored on the problem of the systems and software industry. Reuse of products, processes and experiences originating from the system life cycle is seen today as a feasible solution to the problem of developing higher quality systems at a lower cost. In fact, quality improvement is very often achieved by defining and developing an appropriate set of strategic capabilities and core competencies to support them. A strategic capability is, in this context, a corporate goal defined by the business position of the organization and implemented by key business processes. Strategic capabilities are supported by core competencies, which are aggregate technologies tailored to the specific needs of the organization in performing the needed business processes. Core competencies are non-transitional, have a consistent evolution, and are typically fueled by multiple technologies. Their selection and development requires commitment, investment and leadership. The paradigm introduced in this paper for developing core competencies is the Quality Improvement Paradigm which consists of six steps: (1) Characterize the environment, (2) Set the goals, (3) Choose the process, (4) Execute the process, (5) Analyze the process data, and (6) Package experience. The process must be supported by a goal oriented approach to measurement and control, and an organizational infrastructure, called Experience Factory. The Experience Factory is a logical and physical organization distinct from the project organizations it supports. Its goal is development and support of core competencies through capitalization and reuse of its cycle experience and products. The paper introduces the major concepts of the proposed approach, discusses their relationship with other approaches used in the industry, and presents a case in which those concepts have been successfully applied.
BMP-4 inhibits neural differentiation of murine embryonic stem cells (1999)

Members of the transforming growth factor-beta superfamily, including bone morphogenetic protein 4 (BMP-4), have been implicated as regulators of neuronal and glial differentiation. To test for a possible role of BMP-4 in early mammalian neural specification, we examined its effect on neurogenesis in aggregate cultures of mouse embryonic stem (ES) cells. Compared to control aggregates, in which up to 20% of the cells acquired immunoreactivity for the neuron-specific antibody TuJ1, aggregates maintained for 8 days in serum-free medium containing BMP-4 generated 5- to 10-fold fewer neurons. The action of BMP-4 was dose dependent and restricted to the fifth through eighth day in suspension. In addition to the reduction in neurons, we observed that ES cell cultures exposed to BMP-4 contained fewer cells that were immunoreactive for glial fibrillary acidic protein or the HNK-1 neural antigen. Furthermore, under phase contrast, cultures prepared from BMP-4-treated aggregates contained a significant proportion of nonneuronal cells with a characteristic flat, elongated morphology. These cells were immunoreactive for antibodies to the intermediate filament protein vimentin; they were rare or absent in control cultures. Treatment with BMP-4 enhanced the expression of the early mesodermal genes brachyury and tbx6 but had relatively little effect on total cell number or cell death. Coapplication of the BMP-4 antagonist noggin counteracted the effect of exogenous BMP-4, but noggin alone had no effect on neuralization in either the absence or presence of retinoids. Collectively, our results suggest that BMP-4 can overcome the neuralizing action of retinoic acid to enhance mesodermal differentiation of murine ES cells.
Effectiveness of organic acid, ozonated water and chlorine dippings on microbial reduction and storage quality of fresh‐cut iceberg lettuce (2007)

Lactic and citric acid and ozonated water dippings could be alternative treatments to chlorine dipping to prolong the shelf life of fresh-cut iceberg lettuce. Copyright © 2007 Society of Chemical Industry.
Effect of soft and softer handoffs on CDMA system capacity (1998)

The effect of soft and softer handoffs on code-division multiple-access (CDMA) system capacity is evaluated for unsectorized and sectorized hexagonal cells according to an average bit energy-to-interference power spectral density, which corresponds to a bit-error rate (BER) of 10/sup -3/. The effect of imperfect sectorization on sectorization efficiency is also considered. On the reverse link, there is no capacity loss as no extra channels are needed to perform soft handoff, while the macrodiversity provided by soft handoff can improve the reverse-link quality and extend the cell coverage. On the forward link, when soft handoff is employed in unsectorized cells, the capacity loss due to two traffic channels assigned to a user in the handoff zone is 0.2% or 1.1% for a voice activity factor of 3/8 or 1/2, respectively. As the forward-link capacity is higher than that of the reverse link, this small capacity loss does not affect the system capacity. For sectorized cells having three sectors per cell, there are overlapping coverage areas between sectors, where mobiles in these areas are subjected to an increase in cochannel interference. For an overlapping angle of 5/spl deg/, the sectorization efficiency is 0.96 and 0.7 for the reverse-link and forward-link systems, respectively. When soft and softer handoffs are employed, the forward-link sectorization efficiency is improved to 0.97. We find the application of soft and softer handoff improves not only the forward-link capacity, but also the signal-to-interference ratio (SIR) for mobiles near the cell and sector boundaries.
A high-throughput fully hardwired CABAC encoder for QFHD H.264/AVC main profile video (2010)

We propose a very high-throughput fully hardwired CABAC encoder for ultra-high resolution video. Our architecture includes hardwired circuits for binarization, context modeling, neighbor data access, and a six-stage pipelined binary arithmetic encoder (BAE). Our BAE can encode multiple bins per cycle. In order to keep up with the BAE throughput, we propose acceleration methods for the bin and context index generations of several types of frequent syntax elements (SE). We further propose a novel architecture that shortens the critical path of renormalization and bitstream generation. Our design can encode 1.42 bins per cycle on the average, and it achieves a throughput of 315 Mbin/sec. Simulation results show that it can real-time encode QFHD (3840×2176) video at 30 fps or 1080 HD (1920×1088) at 60 fps for H.264/AVC main profile, level 5.1 by running at 222 MHz. We have successfully integrated the proposed CABAC encoder into an H.264/AVC encoder system using an SoC platform.
Anonymizing transaction databases for publication (2008)

This paper considers the problem of publishing "transaction data" for research purposes. Each transaction is an arbitrary set of items chosen from a large universe. Detailed transaction data provides an electronic image of one's life. This has two implications. One, transaction data are excellent candidates for data mining research. Two, use of transaction data would raise serious concerns over individual privacy. Therefore, before transaction data is released for data mining, it must be made anonymous so that data subjects cannot be re-identified. The challenge is that transaction data has no structure and can be extremely high dimensional. Traditional anonymization methods lose too much information on such data. To date, there has been no satisfactory privacy notion and solution proposed for anonymizing transaction data. This paper proposes one way to address this issue.
Mn-Mediated Coupling of Alkyl Iodides and Ketimines: A Radical Addition Route to α,α-Disubstituted α-Aminoesters (2008)

Coupling of primary and secondary alkyl iodides with N-acylhydrazonoesters via Mn-mediated photolysis conditions affords access to tert-alkyl amines.
Hydration during Intense Exercise Training (2013)

Hydration status has profound effects on both physical and mental performance, and sports performance is thus critically affected. Both overhydration and underhydration - if sufficiently severe - will impair performance and pose a risk to health. Athletes may begin exercise in a hypohydrated state as a result of incomplete recovery from water loss induced in order to achieve a specific body mass target or due to incomplete recovery from a previous competition or training session. Dehydration will also develop in endurance exercise where fluid intake does not match water loss. The focus has generally been on training rather than on competition, but sweat loss and fluid replacement in training may have important implications. Hypohydration may impair training quality and may also increase stress levels. It is unclear whether this will have negative effects (reduced training quality, impaired immunity) or whether it will promote a greater adaptive response. Hypohydration and the consequent hyperthermia, however, can enhance the effectiveness of a heat acclimation program, resulting in improved endurance performance in warm and temperate environments. Drinking in training may be important in enhancing tolerance of the gut when athletes plan to drink in competition. The distribution of water between body water compartments may also be important in the initiation and promotion of cellular adaptations to the training stimulus.
In vivo control of differentiation of myeloid leukemic cells by cyclosporine A and recombinant interleukin-1 alpha (1988)

There are different types of hematopoietic regulatory proteins that regulate the multiplication and differentiation of normal myeloid cells. These different types include four growth-inducing proteins called colony-stimulating factors (CSF), including interleukin-3 (IL- 3), or macrophage and granulocyte inducers, type 1 (MGI-1); another type (called MGI-2) that induces myeloid differentiation of normal myeloid cells without inducing myeloid cell multiplication; and interleukin-1 (IL-1), which can act on myeloid precursor cells. Different clones of myeloid leukemic cells can differ in their ability to be induced to undergo terminal cell differentiation by different hematopoietic regulatory proteins. We have now studied the ability of cyclosporine A and recombinant IL-1 alpha to regulate in vivo differentiation of different clones of myeloid leukemic cells that are either susceptible or resistant to induction of differentiation by IL-1 in vitro. The results show that (a) cyclosporine A, like other immune- suppressing compounds such as cyclophosphamide, inhibited in vivo differentiation of myeloid leukemic cells and differentiation was restored by injecting recombinant GM-CSF; (b) recombinant IL-1 alpha induced in vivo terminal differentiation of IL-1-sensitive but not IL-1- resistant clones of myeloid leukemic cells; (c) IL-1 alpha and GM-CSF synergistically induced differentiation in vivo in a GM-CSF-responsive and IL-1-nonresponsive clone of leukemic cells; and (d) IL-1 alpha induced in vivo the rapid production and release into serum of the differentiation-inducing protein MGI-2 as well as the growth-inducing proteins M-CSF and G-CSF.
SEPARATION AND CHARACTERIZATION OF TWO RAT-INTESTINAL AMYLASES (1963)

During a recent study of the carbohydrases of rat-intestinal mucosa, the amylase activity was found to yield two separate peaks on ion-exchange chromatography (Dahlqvist, 1963). This paper deals with the characterization of the two enzymes responsible for the amylase activity of these extracts.
N<sup>1</sup>,N<sup>4</sup>-Pyrazinoyl<sup>1</sup> Derivatives of Sulfanilamide (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN1,N4-Pyrazinoyl1 Derivatives of SulfanilamideT. C. Daniels and Harry IwamotoCite this: J. Am. Chem. Soc. 1941, 63, 1, 257–258Publication Date (Print):January 1, 1941Publication History Published online1 May 2002Published inissue 1 January 1941https://pubs.acs.org/doi/10.1021/ja01846a060https://doi.org/10.1021/ja01846a060research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intra-oocyte Localization of MAD2 and Its Relationship with Kinetochores, Microtubules, and Chromosomes in Rat Oocytes During Meiosis1 (2004)

The present study was designed to investigate subcellular localization of MAD2 in rat oocytes during meiotic maturation and its relationship with kinetochores, chromosomes, and microtubules. Oocytes at germinal vesicle (GV), prometaphase I (ProM-I), metaphase I (M-I), anaphase I (A-I), telophase I (T-I), and metaphase II (M-II) were fixed and immunostained for MAD2, kinetochores, microtubules and chromosomes. The stained oocytes were examined by confocal microscopy. Some oocytes from GV to M-II stages were treated by a microtubule disassembly drug, nocodazole, or treated by a microtubule stabilizer, Taxol, before examination. Anti-MAD2 antibody was also injected into the oocytes at GV stage and the injected oocytes were cultured for 6 h for examination of chromosome alignment and spindle formation. It was found that MAD2 was at the kinetochores in the oocytes at GV and ProM-I stages. Once the oocytes reached M-I stage in which an intact spindle was formed and all chromosomes were aligned at the equator of the spindle, MAD2 disappeared. However, when oocytes from GV to M-II stages were treated by nocodazole, spindles were destroyed and MAD2 was observed in all treated oocytes. When nocodazole-treated oocytes at M-I and M-II stages were washed and cultured for spindle recovery, it was found that, once the relationship between microtubules and chromosomes was established, MAD2 disappeared in the oocytes even though some chromosomes were not aligned at the equator of the spindle. On the other hand, when oocytes were treated with Taxol, MAD2 localization was not changed and was the same as that in the control. However, immunoblotting of MAD2 indicated that MAD2 was present in the oocytes at all stages; nocodazole and Taxol treatment did not influence the quantity of MAD2 in the cytoplasm. Significantly higher proportions of anti-MAD2 antibody-injected oocytes proceeded to premature A-I stage and more oocytes had misaligned chromosomes in the spindles. The present study indicates that MAD2 is a spindle checkpoint protein in rat oocytes during meiosis. When the spindle was destroyed by nocodazole, MAD2 was reactivated in the oocytes to overlook the attachment between chromosomes and microtubules. However, in this case, MAD2 could not check unaligned chromosomes in the recovered spindles, suggesting that a normal chromosome alignment is maintained only in the oocytes without any microtubule damages during maturation.
Adsorption of Small Organic Molecules on Graphene (2013)

We present a combined experimental and theoretical quantification of the adsorption enthalpies of seven organic molecules (acetone, acetonitrile, dichloromethane, ethanol, ethyl acetate, hexane, and toluene) on graphene. Adsorption enthalpies were measured by inverse gas chromatography and ranged from -5.9 kcal/mol for dichloromethane to -13.5 kcal/mol for toluene. The strength of interaction between graphene and the organic molecules was estimated by density functional theory (PBE, B97D, M06-2X, and optB88-vdW), wave function theory (MP2, SCS(MI)-MP2, MP2.5, MP2.X, and CCSD(T)), and empirical calculations (OPLS-AA) using two graphene models: coronene and infinite graphene. Symmetry-adapted perturbation theory calculations indicated that the interactions were governed by London dispersive forces (amounting to ∼60% of attractive interactions), even for the polar molecules. The results also showed that the adsorption enthalpies were largely controlled by the interaction energy. Adsorption enthalpies obtained from ab initio molecular dynamics employing non-local optB88-vdW functional were in excellent agreement with the experimental data, indicating that the functional can cover physical phenomena behind adsorption of organic molecules on graphene sufficiently well.
Expanding Neutrophil Horizons: New Concepts in Inflammation (2018)

Research into neutrophil biology in the last 10 years has uncovered a number of unexpected aspects of this still mysterious innate immune cell. Advances in technology have allowed visualisation of neutrophil trafficking to sites of inflammation, and, remarkably, neutrophils have been observed to depart from the scene in what has been termed reverse migration. There has also been increasing appreciation of the heterogeneity of neutrophils with ongoing categorisation of neutrophil subsets, including myeloid-derived suppressor cells and low-density granulocytes. Newly recognised neutrophil functions include the ability to release novel immune mediators such as extracellular DNA and microvesicles. Finally, studies of neutrophil cell death, both apoptotic and non-apoptotic, have revealed remarkable differences compared to other cell types. This review will highlight important discoveries in these facets of neutrophil biology and how the new findings will inform treatment of diseases where neutrophils are implicated.