gebhart/patrepeval huggingface dataset:
Multicenter cooperative case survey of hepatitis B virus reactivation by chemotherapeutic agents (2015)

Most of the patients with HBV reactivation who were HBsAg negative prior to the chemotherapy had underlying hematological malignancies. Furthermore, patients with hematological malignancies often developed late-onset HBV reactivation. The prognosis of patients who develop acute liver dysfunction as a complication of HBV reactivation is extremely dismal.
InGaPAs-InP double-heterojunction high-radiance LED's (1979)

InGaPAs-InP double-heterojunction (DH) high-radiance LED's (λ ∼ 1.05-1.3 µm) have been fabricated by liquid-phase epitaxy (LPE) at constant temperature. The crystal growth procedure is described and the influence of InP substrate crystalline perfection is discussed. LED's with a high-radiance geometry suitable for coupling to an optical fiber have been fabricated. The four-layer double-heterostructure LED's have low forward-biased resistances. Typical external quantum efficiencies of ∼1.5 percent and narrow emission linewidths (∼56 nm, typical), have been measured for LED's (λ ∼ 1.08 µm) with an InGaPAs active layer thickness of 1.6 µm and an active layer carrier concentration of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N_{A} - N_{D} \approx 2.8 \× 10^{16}</tex> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> . The dependence of LED emission linewidth upon active layer doping is reported. Transient measurements show that the LED rise time is dependent upon current density for high-injection conditions. Preliminary lifetest results demonstrate only slight LED degradation after operation at 50 and 70°C for times up to ∼3500 h.
Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas (2010)

Transformation of epithelial cells is associated with loss of cell polarity, which includes alterations in cell morphology as well as changes in the complement of plasma membrane proteins. Rab proteins regulate polarized trafficking to the cell membrane and therefore represent potential regulators of this neoplastic transition. Here we have demonstrated a tumor suppressor function for Rab25 in intestinal neoplasia in both mice and humans. Human colorectal adenocarcinomas exhibited reductions in Rab25 expression independent of stage, with lower Rab25 expression levels correlating with substantially shorter patient survival. In wild-type mice, Rab25 was strongly expressed in cells luminal to the proliferating cells of intestinal crypts. While Rab25-deficient mice did not exhibit gross pathology, ApcMin/+ mice crossed onto a Rab25-deficient background showed a 4-fold increase in intestinal polyps and a 2-fold increase in colonic tumors compared with parental ApcMin/+ mice. Rab25-deficient mice had decreased β1 integrin staining in the lateral membranes of villus cells, and this pattern was accentuated in Rab25-deficient mice crossed onto the ApcMin/+ background. Additionally, Smad3+/– mice crossed onto a Rab25-deficient background demonstrated a marked increase in colonic tumor formation. Taken together, these results suggest that Rab25 may function as a tumor suppressor in intestinal epithelial cells through regulation of protein trafficking to the cell surface.
The Determination of<scp>d</scp>-Glutamic Acid and<scp>d</scp>-Aspartic Acid by Means of a New Oxidase (1956)

The fractional determination of d-glutamic and d-aspartic acids using the enzyme preparation of Aspergillus ustus strain f. was studied. In the first part of this paper, the procedure of enzyme preparation, the effect of sodium chloride on enzyme activity, and a new device for the fractional determination of d-glutamic and d-aspartic acids are described. In the latter part, the contents of d-glutamic and d-aspartic acids of cancer and normal tissues are estimated. However, it was found that the cancer tissues are not characterized by the presence of d-glutamic acid in opposition to Kögl’s claim.
The Role of Effective Clinician-Patient Communication in the Management of Irritable Bowel Syndrome and Chronic Constipation (2012)

Irritable bowel syndrome (IBS) and chronic constipation (CC) are common functional bowel disorders that are among the most frequent reasons for referral to a gastroenterologist. Diagnosis and management of these conditions can be challenging for both the clinician and the patient for a number of reasons. Diagnosis can be complicated by the lack of a specific diagnostic test and the fact that IBS and CC are multisymptomatic conditions, whereas management can be suboptimal, because the conditions are often undiagnosed and self-managed by the patient. Furthermore, these are chronic conditions that must be managed over the long term, which can often lead to frustration both on the part of the patient and the clinician. As such, the role of the therapeutic clinician-patient relationship in diagnosis and management of these conditions has been attracting increasing attention. A patient-centered approach with a strong focus on effective communication between the clinician and the patient has been recommended for management of functional bowel diseases such as IBS and CC and has been associated with improved outcomes, increased patient satisfaction, and decreased utilization of care. The potential benefit of such practices as asking open-ended questions, actively listening to the patient, and displaying empathy in strengthening the clinician-patient relationship are highlighted in this manuscript. These skills have broad application in clinical medicine and can be used to improve clinician-patient communication in the management of patients with chronic illnesses.
Ki67 Overexpression in mucosa distant from oral carcinoma: A poor prognostic factor in patients with long-term follow-up (2016)

The present study confirmed the role of Ki67 in tumor-distant areas as a prognostic marker for OSCC patients.
LATERAL CONTROL OF HOVERING VEHICLES WITH AND WITHOUT SLING LOADS. (1966)

Open-loop and closed-loop lateral dynamics of hovering vehicles with and without sling loads are analyzed. Both human and automatic control are considered. Equations of motion are derived and factored transfer functions are presented for typical single- and tandem-rotor helicopters. The open-loop dynamics are shown to be similar to the longitudinal dynamics described in a preceding report. The effect of various feedbacks on closed-loop dynamics is studied. Particular attention is given to their effectiveness in relieving the load on the pilot, and he is included in the analysis through use of the human pilot describing function. The 'sensitivity vector' method of analyzing multiloop feedbacks is introduced; this method facilitates swift assessment of complicated and unusual feedbacks, such as lateral acceleration, sling angle relative to the vehicle centerline, and the output of tilted rate gyros. These feedbacks, and some others, are examined, but it is concluded that they are inferior to the conventional feedbacks of bank angle and roll rate to roll control, and heading and yaw rate to yaw control. It is shown that even the latter feedbacks require adjustment to cope effectively with differences between the 'with sling' and 'no sling' conditions. (Author)
<title>Physical and chemical factors governing dissolution of novolak resin films</title> (1993)

The authors have investigated the dissolution of a series of novolac resins with different structures and properties with various quaternary ammonium hydroxides using a new technique called Spectroscopic Dissolution Rate Monitoring (SDRM). This technique allows direct spectral measurement of an absorption band attributed to cation complex formation. The rate of formation of this complex is used as an approximation or surrogate for cation diffusion. The rate of formation of the complex is approximately the same as the rate of dissolution when using a rinse. This evidence supports cation diffusion as the rate determining step even in TMAH development of high ortho, ortho bonded systems. Our studies also suggest that polymer flexibility and microstructure exert a strong influence on the cation diffusion rate.
The Oberon System family (1995)

Abstract Oberon simultaneously refers to a moduar, extensible operating system and an object‐oriented programming language developed for its implementation. Although the original Oberon System had been conceived as the native operating system for a custom‐built workstation, furhter implementations for several commercial platforms were developed later and are described here. All of these implementations are based on an efficient, retargetable Oberon compiler, and each provides a complete Oberon environment and the original library interface. This paper describes the structure of the compiler, summarizes the experience gained in adapting it for various CISC and RISC processors, and presents some empirical performance data. It also sheds light on the task of grafting an operating environment onto a variety of existing operating systems.
[Effects of low doses of activated protein C in experimental arterial thrombosis in rats]. (1990)

Activated C protein (ACP) is a physiological anticoagulant enzyme that is capable to inactivate factors Va and VIIIa, thereby having a wide spectrum of antithrombotic effects. Low-dose ACP was tested for its ability to affect anodic current-induced arterial thrombosis in the rat. ACP given in low doses (15 micrograms/kg, 7% of total C protein in the rat) was found to produce a marked antithrombotic effect. With this, the activated partial thromboplastin time remained virtually unchanged, and its antithrombotic action was equal to that of heparin administered in a dose of 125 U/kg. In the authors' opinion, ACP may form the basis for designing a highly effective antithrombotic agent.
Toward a new Reynolds stress model for rotating turbulent flows (1992)

A new approach for modeling turbulent rotating flows is presented. The main objective of this model is to take into account the complex effects of background rotation, which have been elucidated by homogeneous spectral analysis. The model is based on the following elements. First, it is shown, or recalled, that the use of the deviatoric part aij=Rij/Rll−δij/3 of the Reynolds stress tensor Rij as the unique tensorial argument for closing unknown terms (a basic principle in actual models) is no longer valid in the presence of solid body rotation. A decomposition of this tensor into two parts (aij=aeij+aZij), namely aeij (directional dependence) and aZij (polarization), is suggested from pure inviscid and homogeneous rapid distortion theory. It is shown that the first part aeij is preserved while the second aZij is damped by the pressure-velocity correlations through the action of the Coriolis force. This decomposition appears to provide the minimum amount of information in physical space needed to deal with the complexity of the problem. A system of equations for aeij and aZij is then given for predicting in an ‘‘ad hoc’’ way some phenomena consistent with those identified by spectral models, recent direct numerical simulations (DNS), and experimental results. These phenomena are: (1) damping of any term attached to nonlinear interactions at very low Rossby numbers, in accordance with a convenient modification (for rotation) in the ε (dissipation rate) equation, (2) linear ‘‘rapid’’ reorganization of an initial anisotropy, as shown by pure inviscid rapid distortion theory, and (3) nonlinear ‘‘Taylor–Proudman structuring’’ at intermediate Rossby numbers. Although the present model is restricted to the case of pure solid body rotation, developments that could lead to a more general version that takes into account any kind of mean velocity gradient are discussed at the end of the paper. For this purpose, a consistent closure is provided for the ‘‘rapid’’ pressure rate of the strain correlation tensor Φ2ij=eΦ2ij+ZΦ2ij (involved in the Rij equation), and for the related contribution involved in the equation for Reij=Rllaeij, without introducing any adjustable constant. Finally, we present a general two-tensor model (Rij,Reij;ε) of which we hope will encourage new efforts in second-order modeling.
Strahlentherapie mit schweren Ionen (1998)

Abstract Im Dezember 1997 wurden erstmals in Europa Tumorpatienten mit hochenergetischen Kohlenstoffionen bestrahlt. In den nächsten Jahren sollen einige hundert Patienten mit Tumoren im Hirn‐ und Schädelbasisbereich behandelt werden. Ziel ist die Entwicklung einer Tumortherapie mit schweren Ionen für den Klinikbereich, mit der mehr als tausend Patienten pro Jahr behandelt werden können.
Molecular and Clinical Analysis of Japanese Patients with Persistent Congenital Hyperinsulinism: Predominance of Paternally Inherited Monoallelic Mutations in the K<sub>ATP</sub>Channel Genes (2010)

The majority of the Japanese patients with K(ATP) channel hyperinsulinism (84.2%) demonstrated paternally inherited monoallelic mutations that accurately predicted the presence of the focal form.
ChemInform Abstract: SULFOAETHYLIERUNG 1. MITT. TAURINE UND TAUROBETAINE AUS PRIMAEREN ODER SEKUNDAEREN AMINEN (1970)

Abstract Durch Reaktion des Amins (I) in Methylenchlorid mit den Estern (II) (equimolare Mengen) bilden sich die Aminosulfonate (III) (39‐63% Ausbeute), die sehr instabil sind.
GAS-EXPOSURE LABELING OF ORGANICS WITH TRITIUM (1962)

Eyelid and orbital diseases during childhood may require fast surgical intervention to prevent amblyopia. Initial conservative treatment is recommended for connatal dacryostenosis and capillary hemangioma.
Symbiosis in scale out networking and data management (2012)

This talk highlights the symbiotic relationship between data management and networking through a study of two seemingly independent trends in the traditionally separate communities: large-scale data processing and software defined networking. First, data processing at scale increasingly runs across hundreds or thousands of servers. We show that balancing network performance with computation and storage is a prerequisite to both efficient and scalable data processing. We illustrate the need for scale out networking in support of data management through a case study of TritonSort, currently the record holder for several sorting benchmarks, including GraySort and JouleSort. Our TritonSort experience shows that disk-bound workloads require 10 Gb/s provisioned bandwidth to keep up with modern processors while emerging flash workloads require 40 Gb/s fabrics at scale.
Monoclonal antibodies and coupling reagents to cell membrane proteins for leukocyte labeling (1984)

Current gamma-emitting agents for tagging leukocytes, In-111 oxine or tropolone, label all cell types indiscriminantly, and nuclear localization in lymphocytes results in radiation damage. Coupling reagents and murine monoclonal antibodies (Mab) specific for cell surface antigens of human leukocytes were tried as cell labeling agents to avoid nuclear localization. 10/sup 8/ mixed human leukocytes in Hepes buffer were added to tubes coated with 5 mg of dry cyclic dianhydride of DTPA for 15 minutes at room temperature. After washing, 0.1 ml of In-111 Cl in ACD (pH 6.8) was added. After 30 minutes, a cell labeling yield of 23% was obtained. Washing the cells in an elutriation centrifuge showed that this label was irreversible. Mab for cell surface antigens of human granulocytes were labeled with 300 ..mu..Ci of I-125 using the Iodobead technic and unbound activity was removed by gel column chromatography. 1-10 ..mu..g were added to 10/sup 8/ mixed leukocytes in 0.5 ml plasma or saline for 1 hr. With Mab anti-leu M4 (clone G7 E11), an IgM, the cell labeling yield was 21%, irreversible, and specific for granulocytes. With anti-human leukocyte Mab NEI-042 (clone 9.4), and IgG2a, and anti-granulocyte Mab MAS-065 (clone FMCl1) an IgG1, the cell labelingmore » was relatively unstable. Labeling of leukocyte subpopulations with Mab is feasible, and the binding of multivalent IgM is stronger than that of other immunoglobulins. DTPA cyclic anhydride is firmly bound to cell membranes, but the labeling is non-specific.« less
Structure of allylic Grignard reagents (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of allylic Grignard reagentsD. A. Hutchison, K. R. Beck, R. A. Benkeser, and J. B. GrutznerCite this: J. Am. Chem. Soc. 1973, 95, 21, 7075–7082Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ja00802a031https://doi.org/10.1021/ja00802a031research-articleACS PublicationsRequest reuse permissionsArticle Views714Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient Design of Integrated Wideband Polarization Splitter/Combiner (2010)

We propose a novel design of integrated polarization splitter/combiner with ultra wide bandwidth. The proposed design utilizes the electro-optic (Pockels) effect in GaAs for splitting the polarizations. It also exploits the self imaging phenomenon in MMI couplers with a parabolic index distribution in the vertical direction to significantly increase the bandwidth. We also propose a novel approach for design optimization of the proposed structure. This approach is capable of extracting the propagation constants and their gradient with respect to all the design parameters. This allows for using gradient-based optimization. The computational time of this optimization procedure is only a fraction of that for other recently proposed approaches.
<b>The Diels-Alder Reaction with Thebaine. Thermal Rearrangement of Some Adducts from Acetylenic Dienophiles</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Diels-Alder Reaction with Thebaine. Thermal Rearrangement of Some Adducts from Acetylenic DienophilesHenry. Rapoport and Peter. SheldrickCite this: J. Am. Chem. Soc. 1963, 85, 11, 1636–1642Publication Date (Print):June 1, 1963Publication History Published online1 May 2002Published inissue 1 June 1963https://pubs.acs.org/doi/10.1021/ja00894a022https://doi.org/10.1021/ja00894a022research-articleACS PublicationsRequest reuse permissionsArticle Views180Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Joint Adaptive Rate and Scheduling for Video Streaming in Multi-Cell Cellular Wireless Networks (2014)

We consider adaptive-rate scheduling for downlink unicast transmissions of video streams over cellular wireless networks. We study a service under which each mobile client receives requested video streams at a variable Quality of Experience (QoE) level, based on its experienced communication quality condition. We employ a proxy-video manager at the base station node. The manager classifies users into two groups, based on their reported experienced CQIs (Channel Quality Indicators). The manager intercepts a client's video stream request destined to the HTTP server, determines its group classification, and proceeds to transmit a properly encoded version of the requested stream. To effectively regulate inter- cell signal interference, we examine a number of different spectral reuse and fractional frequency reuse scheduling schemes. We calculate, for each scheduling and user group classification scheme, the average bandwidth per stream that is required to provide user groups with their targeted QoE levels. We demonstrate a user classification process that aims to optimize a utility metric based on the definition of a will-to-pay utility function. The derived optimal configuration of FFR based schemes are shown to significantly enhance the system's performance behavior.
Synthesis based on cyclohexadienes. Part 34. A tandem cationic rearrangement–ene cyclisation route to 2-pupukeanone (2000)

A new strategy for the construction of the isotwistane skeleton is reported from easily available cyclohexadienes, which involves a one-pot cationic skeletal rearrangement and ene cyclisation of a bicyclo[2.2.2]octenone derivative and a cationic rearrangement of a tricyclo[5.3.0.04,8]decane to a [4.3.1.03,7]decane skeleton as the key steps in the synthesis of 2-pupukeanone.
The Seasonal Evolution of Reactive Chlorine in the Northern Hemisphere Stratosphere (1993)

In situ measurements of chlorine monoxide (ClO) at mid- and high northern latitudes are reported for the period October 1991 to February 1992. As early as mid-December and throughout the winter, significant enhancements of this ozone-destroying radical were observed within the polar vortex shortly after temperatures dropped below 195 k. Decreases in ClO observed in February were consistent with the rapid formation of chlorine nitrate (ClONO(2)) by recombination of ClO with nitrogen dioxide (NO(2)) released photochemically from nitric acid (HNO(3)). Outside the vortex, ClO abundances were higher than in previous years as a result of NOx suppression by heterogeneous reactions on sulfate aerosols enhanced by the eruption of Mount Pinatubo.
FATIGUE STRENGTH OF WELDED TUBULAR JOINTS IN OFFSHORE STRUCTURES (1975)

This paper describes experiments and analyses for a study on fatigue strength of tubular joints generally used for column stabilized drilling units or drilling platforms on the sea. It presents a fundamental guidance and data to designers engaged in this field by discussing the fatigue strength of such joints under complicated stresses and the most effective type of joint.