gebhart/patrepeval huggingface dataset:
A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis (2015)

Primary sclerosing cholangitis (PSC) can be complicated by the development of biliary malignancy as cholangiocarcinoma (CCA) and gallbladder carcinoma (GBCA). Besides the most commonly used serum screening parameter, namely CA19 – 9, screening with serum levels of carcinoembryonic antigen (CEA) is less examined. We thus conducted a study to investigate carcinoembryonic antigen (CEA) as a screening parameter for biliary malignancy in PSC patients. Based upon findings of a recent genome-wide association study that described an association between the genes of fucosyltransferases (FUT) and CEA, we thought to analyze how serum CEA levels were affected by common genetic variants of FUT2 and FUT3.
Effect of temporal collaboration network, maintenance activity, and experience on defect exposure (2014)

Context: Number of defects fixed in a given month is used as an input for several project management decisions such as release time, maintenance effort estimation and software quality assessment. Past activity of developers and testers may help us understand the future number of reported defects. Goal: To find a simple and easy to implement solution, predicting defect exposure. Method: We propose a temporal collaboration network model that uses the history of collaboration among developers, testers, and other issue originators to estimate the defect exposure for the next month. Results: Our empirical results show that temporal collaboration model could be used to predict the number of exposed defects in the next month with R2 values of 0.73. We also show that temporality gives a more realistic picture of collaboration network compared to a static one. Conclusions: We believe that our novel approach may be used to better plan for the upcoming releases, helping managers to make evidence based decisions.
Assignment of sterol carrier protein X/sterol carrier protein 2 to 1p32 and its exclusion as the causative gene for infantile neuronal ceroid lipofuscinosis (1994)

In the positional cloning of a disease gene with an unknown protein defect a spectrum of molecular biological methods is applied after linkage has been established. It is reasonable to analyze in detail any relevant candidate gene mapping to the particular chromosomal region. We report here the refined chromosomal assignment of SCPx/SCP2, a gene coding for the protein that is believed to have an important role in lipid metabolism by transporting many kinds of lipid molecules between organelles. This gene represents an excellent candidate gene for infantile neuronal ceroid lipofuscinosis, earlier assigned to 1p32 by us, since lipid metabolism in the patient's brain appears to be significantly disturbed. Expression and structural analyses by Northern, Southern and Western blotting as well as SSCP and direct sequencing did not detect any differences between the cDNAs of patients and controls. Consequently, it is unlikely that a mutation in SCPx/SCP2 is the underlying cause of this severe neurodegenerative disease of childhood.
Scattering parameters of the 3.9 GHz accelerating module in a free-electron laser linac: A rigorous comparison between simulations and measurements (2014)

This article presents a comparison between measured and simulated scattering parameters in a wide frequency interval for the third harmonic accelerating module ACC39 in the linear accelerator FLASH, located at DESY in Hamburg/Germany. ACC39 is a cryomodule housing four superconducting 3.9 GHz accelerating cavities. Due to the special shape of the cavities (in particular its end cells and the beam pipes) in ACC39, the electromagnetic field in the module is, in many frequency ranges, coupled from one cavity to the next. Therefore, the scattering parameters are determined by the entire string and not solely by the individual cavities. This makes the determination of the scattering properties demanding. As far as the authors can determine, this paper shows for the first time a direct comparison between state-of-the-art simulations and measurements of rf properties of long, complex, and asymmetric structures over a wide frequency band. Taking into account the complexity of the system and various geometrical unknowns, the agreement between experimental measurements and simulations is remarkably good for several distinct measurements, although a variety of effects (e.g. cavity deviations from the ideal shape or interactions with not modeled parts of the structure) is not considered in the computer simulation. After a short introduction, the paper provides detailed descriptions of simulations and experimental measurements performed at the module. In this context, the estimation of the cable properties is discussed as well. As a central part of the article, the comparison between measured and simulated transmission spectra and quality factors is presented. This study represents one of the first detailed comparisons between simulations and measurements for a coupled accelerator cavity system.
Herpes Simplex Virus Type 2 Shedding in Human Immunodeficiency Virus—Negative Men Who Have Sex with Men: Frequency, Patterns, and Risk Factors (2000)

We investigated the frequency, site, and risk factors for herpes simplex virus (HSV) shedding in 30 human immunodeficiency virus (HIV)-negative HSV type 2 (HSV-2)-seropositive men who have sex with men. Subjects collected daily HSV culture samples from genital, perianal, and oral areas for 100 days and maintained diaries of signs and symptoms. Sixteen men (53.3%) shed HSV-2, and 9 (56.3%) of 16 men who were also HSV type 1 (HSV-1)-seropositive shed HSV-1. Overall, HSV-2 was isolated on 3.1% of the days; 68% of the isolations were on days that lesions did not occur. HSV-2 shedding was predominantly perianal (83.3%). HSV-1 was isolated on 2.1% of the days; 23 of 24 HSV-1 isolates were from oral areas. Rates of perianal or genital shedding were 6.6% on the days that participants reported prodromal symptoms and 1.9% on the days that participants did not report prodromal symptoms (P<.001). Men seropositive for both HSV-1 and HSV-2 were significantly more likely to shed HSV-2 (odds ratio, 4.1; 95% confidence interval, 1.4-11.9) than were HSV-2-seropositive men. HSV-2-seropositive men who have sex with men have frequent subclinical HSV-2 shedding, usually from the perianal area, and more frequent prodromal HSV-2 shedding.
Communicating Astronomy with a Mass Audience — BBC's Stargazing Live goes Dutch (2015)

Following on from the hugely successful airing of Heel Nederland Kijkt Sterren — a Dutch stargazing event modelled on the BBC’s programme Stargazing Live — this article explores some of the issues involved in communicating astronomydirectly to a mass audience. This includes the production process, co-sponsorship, content, the reach and lessons learned.
Tris[1,1,1-trimethyl-<i>N</i>-(trimethylsilyl)silanaminato]-yttrium (2008)

[447452-96-2] C18H54N3Si3Y (MW 570.06) InChI = 1S/3C6H18NSi2.Y/c3*1-8(2,3)7-9(4,5)6;/h3*1-6H3;/q3*-1;+3 InChIKey = ALBMVGKOSBREQT-UHFFFAOYSA-N (reagent used as a catalyst for functionalization of alkenes and alkynes or as a precursor for preparing yttrium catalysts) Physical Data: mp 161–166 °C. Solubility: soluble in most anhydrous organic solvents, such as THF and toluene. Form Supplied in: colorless solid, commercially available. Commercially available material is colorless to pale yellow depending on its quality. Purification: sublimation (10−4 Torr at 100–105 °C). In most cases, the commercially available reagent can be used as received without purification. Handling, Storage, and Precautions: the reagent is moisture sensitive, corrosive, and should be stored and handled under inert gas atmosphere. Reacts quickly with acids and protic solvents. Anhydrous solvents should be used for reactions.
Enantiomeric Resolution of Cycloenantiomeric Rotaxane, Topologically Chiral Catenane, and Pretzel-Shaped Molecules:  Observation of Pronounced Circular Dichroism (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEnantiomeric Resolution of Cycloenantiomeric Rotaxane, Topologically Chiral Catenane, and Pretzel-Shaped Molecules: Observation of Pronounced Circular DichroismChiyo Yamamoto, Yoshio Okamoto, Thomas Schmidt, Ralf Jäger, and Fritz VögtleView Author Information Department of Applied Chemistry Faculty of Engineering, Nagoya University Furo-Cho, Chikusa-Ku, Nagoya 464-01, Japan Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany Cite this: J. Am. Chem. Soc. 1997, 119, 43, 10547–10548Publication Date (Web):October 29, 1997Publication History Received29 May 1997Revised4 September 1997Published online29 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/ja971764qhttps://doi.org/10.1021/ja971764qrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views2011Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catenanes,Molecular structure,Molecules,Rotaxanes,Sulfones Get e-Alerts
Die Acylierung von Enolethern mit reaktiven Carbonsäurechloriden (Enolether ; 13) (1982)

Enolether 2 lassen sich mit aktivierten Säurechloriden wie den Chloressigsäurechloriden 1a und 1b, Cyanacetylchlorid (6c) oder Malonylchloriden 6a, b unter milden Bedingungen in guten Ausbeuten acylieren. Die Abhängigkeit der Produktbildung und der Ausbeuten vom Acylierungspotential der eingesetzten Säurechloride wird aufgezeigt. Die erhaltenen potentiellen β-Ketoaldehyde 4, 5 bzw. 1,3,5-Tricarbonylverbindungen 8 sind wertvolle Zwischenprodukte für die Synthese von Heterocyclen.
Spin transition under reduction of Ru4+ in YIG:Ru (1982)

Ru substitution strongly affects the anisotropy properties of YIG, shifting the magnetic easy direction from 〈111〉 to 〈100〉. In this paper the spin transition is studied in single crystals containing about 0.15 wt. % of Ru. In particular, the variation is measured of the magnetic easy axis as the Ru4+ concentration is decreased by successive reducing treatments in H2 atmosphere. The decreasing amounts of Ru4+ are monitored by means of the optical absorption peak of octahedral Ru4+, at λ∼1.35 μm. The treatments in H2 result in the formation of OH− groups, whose presence is detected by means of absorption at λ=2.8 μm. We observe a 〈100〉→〈111〉 easy axis transition and find it to be first order, with the two magnetic phases coexisting over a range of Ru4+ concentration. The spin transition is very sensitive to the Ru4+ reduction: from the known values of the magnetic anisotropy constants of Ru in YIG, this may be attributed to the ultimate formation of divalent ruthenium in the reduction process.
Nanopatterned Cadmium Selenide Langmuir–Blodgett Platform for Leukemia Detection (2012)

We present results of the studies relating to preparation of Langmuir-Blodgett (LB) monolayers of tri-n-octylphosphine oxide-capped cadmium selenide quantum dots (QCdSe) onto indium-tin oxide (ITO) coated glass substrate. The monolayer behavior has been studied at the air-water interface under various subphase conditions. This nanopatterned platform has been explored to fabricate an electrochemical DNA biosensor for detection of chronic myelogenous leukemia (CML) by covalently immobilizing the thiol-terminated oligonucleotide probe sequence via a displacement reaction. The results of electrochemical response studies reveal that this biosensor can detect target DNA in the range of 10(-6) to 10(-14) M within 120 s, has a shelf life of 2 months, and can be used about 8 times. Further, this nucleic acid sensor has been found to distinguish the CML-positive and the control negative clinical patient samples.
Some observations of the design of rf coils for human internal use (1988)

Some features of the design and implementation of NMR probes for insertion into peripheral orifices of the body are described. In particular, the possibilities of using parasitic coils without direct connections in conjunction with conventional whole body coils are examined. The use of windings around the NMR probe carrying gradient pulses as a means of eliminating the very high signals from tissue immediately adjacent to the coil windings is also evaluated. These approaches are, in practice, difficult to combine, and hence need to be viewed almost as alternative possibilities. Practical results of experimental investigations are presented using both phantoms and volunteers.
Functionalized Cross-Linked Copolymers: A “C2-Symmetric” Solid-Phase Catalyst for Enantioselective Reactions (1998)

Similar enantiomeric excesses as for analogous monomeric sulfonamides are provided by the chiral resin 1 (connections to the polymer are shown as circles) when it is used as catalyst for the reductive alkylation of aromatic aldehydes and for the cyclopropanation of cinnamyl alcohol.
Performance of a Pulse-Jet Filter at High Filtration Velocity I. Particle Collection (1977)

The fly ash collection characteristics of a pulse-jet fabric filter have been studied. Fly ash penetration was found to decrease as the dust deposit increased from 0 to 60 micrometers in thickness, to increase as face velocity through the bags increased from 5 to 15 cm/s, and to remain relatively constant for particles from 0.3 to 4.0 µm in diameter. Experiments employing chemically tagged fly ash were performed to investigate three dust penetration mechanisms. On resumption of filtering after cleaning, penetration by straight through dust loss declined rapidly from its maximum, reached a minimum, and then increased. Seepage of dust through the fabric was found to be constant throughout the filtration cycle. Dust lost as pinhole plugs increased after cleaning, passed through a maximum, and then declined. The pinholes appeared to open the way for further penetration by the straight through mechanism.
Past, present, and future modeled ozone trends with comparisons to observed trends (1996)

The NASA Goddard Space Flight Center (GSFC) two‐dimensional (2‐D) model of stratospheric transport and photochemistry has been used to predict ozone changes that have occurred in the past 20 years from anthropogenic chlorine and bromine emissions, solar cycle ultraviolet flux variations, the changing sulfate aerosol abundance due to several volcanic eruptions including the major eruptions of El Chichón and Mount Pinatubo, solar proton events (SPEs), and galactic cosmic rays (GCRs). The same linear regression technique has been used to derive profile and total ozone trends from both measurements and the GSFC model. Derived 2‐D model ozone profile trends are similar in shape to the Solar Backscattered Ultraviolet (SBUV) and SBUV/2 trends with highest percentage decreases in the upper stratosphere at the highest latitudes. The general magnitude of the derived 2‐D model upper stratospheric negative ozone trend is larger than the trends derived from the observations, especially in the northern hemisphere. The derived 2‐D model negative trend in the lower stratosphere at middle northern latitudes is less than the measured trend. The derived 2‐D model total ozone trends are small in the tropics and larger at middle and high latitudes, a pattern that is very similar to the Total Ozone Mapping Spectrometer (TOMS) derived trends. The differences between the derived 2‐D model and TOMS trends are generally within 1–2% in the northern hemisphere and the tropics. The derived 2‐D model trends are generally more in southern middle and high latitudes by 2–4%. Our 2‐D model predictions are also compared with the temporal variations in total ozone averaged between 65°S and 65°N over the TOMS observing period (1979–1993). Inclusion of anthropogenic chlorine and bromine increases, solar cycle ultraviolet flux variations, and the changing sulfate aerosol area abundance into our model captures much of the observed TOMS global total ozone changes. The model simulations predict a decrease in ozone of about 4% from 1979 to 1995 due to the chlorine and bromine increases. The changing sulfate aerosol abundances were computed to significantly affect ozone and result in a maximum decrease of about 2.8% in 1992 in the annually averaged almost global total ozone (AAGTO) computed between 65°S and 65°N. Solar ultraviolet flux variations are calculated to provide a moderate perturbation to the AAGTO over the solar cycle by a maximum of ±0.6% (about 1.2% from solar maximum to minimum). Effects from SPEs are relatively small, with a predicted maximum AAGTO decrease of 0.22% in 1990 after the extremely large events of October 1989. GCRs are computed to cause relatively minuscule variations of a maximum of + 0.02% in AAGTO over a solar cycle.
Zero-Speed Operation of High-Power PWM Current-Source-Inverter-Fed Induction Motor Drive (2011)

Most research work in current-source inverter (CSI) fed motor drives has focused on general control strategies, pulsewidth modulation schemes, topologies, and efficiency evaluation. This paper, however, is dedicated to investigating zero-speed operation characteristics of CSI-fed induction motor drives (IMDs). Zero-speed operation can greatly increase the competitive value of the drive and expand its range of applications to include cranes, hoists, and draglines. The motor drive is controlled with rotor flux orientation, where stator currents and motor speed are employed for the rotor flux estimation. Unlike voltage-source-inverter-based drives, filter capacitors are required at the output of the CSI for current commutation and harmonics filtering. The influence of these capacitors on the system dynamic performance is comprehensively evaluated. Moreover, a classic load torque observer with feedforward control is employed to improve the speed dynamic response. Simulated and experimental results show that the CSI-fed IMD works well at zero speed with promising speed dynamic performance.
Combined Effect of Surface Electrostatic Charge and Poly(ethyl glycol) on the Association of Liposomes with Colon Carcinoma Cells (2005)

Particulate drug formulations are considered to be a means that may improve the pharmacokinetics and biodistribution of active compounds. By using them, drug distribution is determined solely by the properties of the carrier. The surface properties of such supramolecular aggregates determine how they will interact with various biological structures. Among others, surface electrostatic charge and surface grafted polymers are considered to be among the major factors affecting its interaction with proteins and cells. In this article, we present experimental evidence that properly selected surface electrostatic charge and grafted polymers can alter the association of liposomes with colon cancer cells. The dependence of the adsorption of liposomes onto the cell surface on the quantity and length of surface grafted polymers for a certain surface charge density exhibits a distinct maximum. For example, when liposomes were formed with 20 mol% of DOTAP, PE-PEG350 increased liposome adsorption by up to 6 mol%. This adsorption maximum depends on both polymer length and charge type. Results presented in this article show that the interaction of liposomes with colon cancer cells can be tuned by a proper combination of liposome surface electrostatics and surface grafted polymers.
(Phenylthio)nitromethane (2003)

Abstract (Phenylthio)nitromethane intermediate: phenylsulfenyl chloride product: (phenylthio)nitromethane
Simultaneous fitting of R‐ and S‐ibuprofen plasma concentrations after oral administration of the racemate (2001)

Aims To assess the pharmacokinetic equivalence of two different formulations of ibuprofen lysinate with special focus on the expected effects. Methods Sixteen healthy volunteers received cross‐over ibuprofen lysinate as either one tablet of 400 mg (‘test’) or two tablets of 200 mg (‘reference’). Ibuprofen plasma concentrations were followed up for 10 h. Bioequivalence was assessed by standard noncompartmental methods. Ibuprofen plasma concentrations were fitted with a model that took bioinversion of R‐ to S‐ibuprofen into account. Results Peak plasma concentrations of R‐ and S‐ibuprofen were 18.1 and 20 µg ml −1 (test), and 18.2 and 20 µg ml −1 (reference). Areas under the plasma concentration vs time curves were 39.7 and 67.5 µg ml −1 h (test), and 41.1 and 68.2 µg ml −1 h (reference). Clearance of R‐ibuprofen was 5.2 (test) and 5 l h −1 (reference). A specific plasma concentration was reached with the test formulation about 5 min later than with the reference. Parameters from compartmental modelling were (given for R‐and then for S‐ibuprofen): body clearance: 4.9 and 4.64 l h −1 , central volume of distribution: 2.8 and 4.1 l, intercompartment clearance: 5.1 and 5.45 l h −1 , peripheral volume of distribution: 4.1 and 5.2 l. The absorption rate constant was 1.52 h −1 , and the test but not the reference formulation had a lag time of 0.1 h. Simulations showed similarity between formulations of the expected effects except for a calculated delay of 6 min with the test formulation. Conclusions Ibuprofen formulations were bioequivalent. The pharmacokinetic model may serve as a basis for future pharmacokinetic/pharmacodynamic calculations after administration of racemic ibuprofen.
Limulus polyphemus lectin sites in human bronchial mucosa. (1977)

The lectin from Limulus polyphemus (limulin) has an affinity for glycoproteins containing N-glycolyl or N-acetylneuraminic residues. By using a peroxidase labeled limulin on human bronchial mucosa sections, it has been possible to demonstrate selectively a diffuse staining within the apical part of the epithelial goblet cells. Whereas, in the submucosal glands serous cells, the labeling appears as small granules localized either at the apical pole or in the whole cytoplasm. In our experimental conditions the labeled limulin has no affinity for mucous cells that are known to contain sialic acid residues.
The next revolution (2003)

The driver/rider experience is a major development in mobile user-interface (UI) design worldwide, similar in scale to the first introduction of personal computers to the desktop. Most automobile manufacturers seeking to develop smart cars have relatively little experience with advanced software-based UIs and information visualization (IV). This panel introduces essential issues of vehicle UI design to the CHI community and offers competing views about the most important issues affecting usability, safety, appeal, functionality, information, and entertainment.
Homeless truths from an agent against poverty (2016)

Twice I have spent a goodly stretch of bright redolent days in Australia, and both times I stayed in the same little friendly unpretentious hotel on Brunswick St, Fitzroy, and both times I wandered widely around the neighbourhood, ambling through the spacious Carlton Gardens, and avoiding the roaring tumultuous pubs after dark, and finding lovely little cafes and music shops and bookstores.