gebhart/patrepeval huggingface dataset:
Modular Approaches to Automation System Design Using Industrial Robots (2008)

A fully automated robotic system was developed and deployed in-house in a modular way to meet the needs of a high throughput chemistry laboratory. The main system components consist of a Stäubli TX60 industrial robot and a Vapourtec V-10 evaporator, with control software by Aitken Scientific. A custom server application was written by Stäubli robotics to interface the robot and control software. The design was done using SolidWorks Computer Aided Design to speed up development, with out-sourced software development and hardware procurement or fabrication. Both hardware and software were modularized such that components could be reused in the future. An industrial robot and original equipment manufacturer (OEM) components were used to improve reliability and minimize support. A custom gripper was designed using a Schunk MPG50 pneumatic two-finger parallel actuator with stainless steel fingers. An injector station was designed to simplify and automate large volume evaporations, with built-in self-cleaning. Custom fabrication of racks, grippers, etc was done using local precision engineering firms. Providing full documentation and training allows support to be done by third-party service engineers. Initial data show that the system is both intuitive and reliable in use.
A new MODEL parameter set for .beta.-lactams (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new MODEL parameter set for .beta.-lactamsKathleen A. Durkin, Michael J. Sherrod, and Dennis LiottaCite this: J. Org. Chem. 1989, 54, 25, 5839–5841Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/jo00286a005https://doi.org/10.1021/jo00286a005research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
P254 NVA237 once daily improves exercise endurance in patients with COPD from the first dose: the GLOW3 trial (2011)

<h3>Introduction</h3> The fundamental characteristics of COPD are exertional dyspnoea and exercise limitation, which are associated with dynamic hyperinflation. We assessed the effects of NVA237 (glycopyrronium bromide), a once-daily long-acting muscarinic antagonist (LAMA), on exercise endurance in patients with moderate-to-severe COPD. <h3>Methods</h3> Patients with COPD were randomised to a cross-over design of NVA237 50 μg or placebo once daily for 3 weeks, with a 14-day washout. The primary endpoint was endurance time during a submaximal constant-load cycle ergometry test (SMETT) on Day 21 of treatment. Endurance time after first dose, dynamic hyperinflation (inspiratory capacity [IC] at isotime during exercise), and morning trough FEV<sub>1</sub> and plethysmographic lung volumes were also measured. <h3>Results</h3> 108 patients were randomised; mean age was 60.5 years, mean post-bronchodilator FEV<sub>1</sub> was 57.1% predicted. 88.0% completed the study. Endurance time on Day 21 significantly increased by 21% with NVA237 vs placebo; the effect was significant from Day 1, with an increase of 10%. Both dynamic IC at exercise isotime and trough FEV<sub>1</sub> showed significant and clinically relevant improvements from Day 1 that were maintained for the study duration (Abstract P254 table 1). This was accompanied by inverse decreases in residual volume and functional residual capacity (Abstract P254 table 1). Overall, the safety profile of NVA237 was similar to that of placebo. <h3>Conclusion</h3> Once-daily NVA237 provided immediate and significant improvement in exercise endurance from Day 1. This was accompanied by sustained and significant improvements in IC at isotime, meaningful improvements in trough FEV<sub>1</sub>, and sustained reductions of lung hyperinflation. There was an improvement in endurance time during the study period, suggesting that mechanisms beyond improved lung function play a part in superior exercise tolerance.
525, 1:1, Progressive Scanning Television Camera with 16:9 Aspect Ratio (1994)

This Paper discusses a 16:9 aspect ratio, 525-line, progressive scanning television camera. This camera employs a newly developed Multiple Frame-Interline-Transfer (M-FIT) CCD and employs digital signal processing technologies. Although picture quality is high, the cost of this camera is not far different from conventional interlace cameras. This paper deals with the M-FIT CCD, the digital signal processing, the transmission of progressive signals, and applications that make good use of the high quality progressive signals.
Real-Time Array Feed Compensation System Demonstrated at JPL (1994)

A real-time array feed compensation system has been constructed, and is currently undergoing tests at JPL.
Poly(3.4-ethylene dioxythiophene)- and polyaniliane-Poly(perfluoroethylenesulfonic acid) as hole injecting layers in polymer light emitting devices (2012)

We present a study of poly(3,4-ethylene dioxythiophene), PEDOT, and polyaniline, where poly(perfluoroethylenesulfonic acid), PFESA has been used as counter ion and dopant respectively. The study wa ...
Proliferative Activity of Benign and Neoplastic Endocervical Epithelium and Correlation with HPV DNA Detection (2002)

Recent studies have indicated that the use of the MIB-1 immunostaining may be useful in distinguishing endocervical neoplasia from benign nonneoplastic lesions. We sought to investigate this finding further with a specific emphasis on the common benign processes that may result in a nonspecific increase of MIB-1 staining. In this study we quantified the MIB-1 immunostaining in the mucinous endocervical epithelium (n=45) and in tubal metaplasia (n=28) during the proliferative and secretory phases (hormonal influence), in the mucinous endocervical epithelium in cases of cervicitis (inflammation) (n=10), in cases with a history of a recent biopsy (regeneration) (n=15), endocervical polyps (benign growth) (n=8), in the endocervical glands adjacent to a squamous intraepithelial lesion (human papilloma virus [HPV] infection) (n=63), and in in situ and invasive cervical adenocarcinomas (n=30). All cases with increased MIB-1 staining were subsequently tested for the presence of HPV DNA. The range of MIB-1 staining in the benign endocervical epithelium was from 0% to 48% and in the neoplastic epithelium from 25% to 84%. MIB-1 staining below 10% always reflected a benign process and MIB-1 staining higher than 50% was always associated with a neoplasia. Rare benign cases (tubal metaplasia during the proliferative phase, glands adjacent to squamous intraepithelial lesions, and cases with a history of a recent biopsy) had increased MIB-1 index, which overlapped with the neoplastic cases. In conclusion, MIB-1 is a useful marker of endocervical neoplasia, although in rare cases an overlap between benign and neoplastic cases may exist.
Femtosecond real-time probing of reactions. IV. The reactions of alkali halides (1989)

The photodissociation dynamics of some alkali halides are explored via the method of femtosecond transition-state spectroscopy (FTS). The alkali halide dissociation reaction is influenced by the interaction between the covalent and the ground state ionic potential energy surfaces (PES), which cross at a certain internuclear separation. Depending upon the adiabaticity of the PES, the dissociating fragments may be trapped in a well formed by the avoided crossing of these surfaces. Here, we detail the FTS results of this class of reactions, with particular focus on the reaction of sodium iodide: NaI*→[Na---I]°* →Na+I. As in our first report [T. S. Rose, M. J. Rosker, and A. H. Zewail, J. Chem. Phys. 88, 6672 (1988)], we observe the dynamical motion of the wave packet along the reaction coordinate and the crossing between the covalent and ionic surfaces. The studies presented here characterize the effects of various experimental parameters, including pump and probe wavelengths, on the dynamics of the dissociation and its detection. Comparisons of the results with classical and quantum mechanical calculations are also presented.
Remeasurement of electrosprayed proteins in the trapped ion cell of a Fourier transform ion cyclotron resonance mass spectrometer (1993)

A single population of multiply charged protein ions formed by electrospray ionization (ESI) is subjected to multiple Fourier transform ion cyclotron resonance (FTICR) excitation and detection events without promoting ion loss from the trapped ion cell. This nondestructive approach to mass spectrometric detection will allow detection limits to be significantly reduced by averaging the repetitive time-domain response that follows each excitation event. Under appropriate conditions, unit remeasurement efficiency is observed for large proteins; for example, 250 consecutive remeasurements of a single population of bovine albumin dimer ions (MW 132,532) yield the expected 16-fold improvement in signal-to-noise ratio compared to a single measurement. Examples presented include a 14-fmol sample of horse myoglobin (MW 16,951), which yields a 15:1 S/N for 50 remeasurements compared to a single scan S/N of 2:1 and a 30-fmol sample of bovine albumin dimer which exhibits a S/N of 25:1 for 50 remeasurements compared to a single scan S/N of 3:1. Of both practical and theoretical interest is the observation of a rapid collision-mediated homogeneous relaxation process that can return these large ions to the center of the cell within a few hundred milliseconds after excitation.
HLA-DRB1*0402 (DW10) Transgene Protects Collagen- Induced Arthritis-Susceptible H2Aq and DRB1*0401 (DW4) Transgenic Mice from Arthritis (2003)

To investigate the role of HLA-DR4 in predisposition to arthritis, we generated transgenic mice carrying DRB1*0401 and DRB1*0402 genes. We have previously shown that DRB1*0401 molecule renders B10.RQB3 (H2A(q)) mice susceptible to porcine and human type II collagen-induced arthritis. We report that the introduction of DRB1*0402 transgene does not lead to development of arthritis in mice when they are immunized with porcine and human type II collagen. In addition, DRB1*0402 protects B10.RQB3 mice against developing arthritis with bovine type II collagen. These data show that DRB1 can modulate the disease mediated by A(q). In vivo depletion of DRB1*0402 did not lead to induction of collagen-induced arthritis in transgenic mice. In vitro cytokine analysis shows that mice protected from collagen-induced arthritis produce lower amounts of Th1 and higher levels of Th2 type cytokines upon immunization with type II collagen. Protection of mice was also related to higher apoptosis in DW10 mice as indicated by higher amounts of BclII in response to type II collagen. On the basis of our observations in HLA transgenic mice, we hypothesize that DRB1 polymorphism can modulate disease by shaping the T cell repertoire in thymus and select autoreactive T cells.
Bursting of a Liquid Film on a Liquid Substrate (1994)

International audience
Antigenic and Biological Relationships between Human Coronavirus OC43 and Neonatal Calf Diarrhoea Coronavirus (1981)

Monospecific antisera were prepared in mice to human coronavirus OC43 and neonatal calf diarrhoea coronavirus (NCDCV) which had been previously adapted to growth in suckling mouse brain. Brain suspension from infected suckling mice was used as immunogen. The antigenic relationship between OC43 and NCDCV was studied by the indirect immunoperoxidase antibody technique, by the haemagglutination-inhibition (HI) test and a new infectious centre-reduction neutralization test. In mouse immune sera, a two-way cross-reaction between OC43 and NCDCV was detected. However, the antigenic relationship appeared to be closer for internal (as shown by immunoperoxidase staining) as compared to surface antigens (as shown by HI and neutralization). In primary infections of natural hosts there was a high degree of cross-reactivity between the two coronavirus strains for both surface and internal antigens, and homologous and heterologous titres were consistently within an eightfold dilution difference by all tests. Most human adults and calves had antibody to both OC43 and NCDCV and geometric mean titres of homologous antibody were higher than titres of heterologous antibody. Although OC43 and NCDCV share antigenic determinants, they possessed several different biological properties, including plaque morphology by the infectious centre assay, agglutination of 1-day-old chick erythrocytes and resistance of haemagglutinin to physical and chemical treatments.
The Importance of Utility Systems in Today’s Biorefineries and a Vision for Tomorrow (2007)

Heat and power systems commonly found in today’s corn processing facilities, sugar mills, and pulp and paper mills will be reviewed. We will also examine concepts for biorefineries of the future. We will show that energy ratio, defined as the ratio of renewable energy produced divided by the fossil energy input, can vary widely from near unity to values greater than 12. Renewable-based utility systems combined with low-fossil input agricultural systems lead to high-energy ratios.
Malignant papillary cystic tumor of the pancreas (1990)

An example of the rare papillary cystic tumor of the pancreas was diagnosed cytologically by aspiration of the primary neoplasm. Subsequently, it metastasized, proving its low-grade malignant behavior. Diagnostic cytomorphologic features included abundant straight and branched papillary tissue fragments, and uniform, pale nuclei with folds or grooves. Although the primary tumor had a typical histologic appearance, metastases demonstrated increased nuclear pleomorphism and hyperchromasia, bizarre tumor giant cells, and an increased mitotic rate. Vimentin was diffusely positive, whereas neuron-specific enolase and somatostatin were focally and weakly reactive. Neurosecretory and zymogen granules were absent ultrastructurally. By flow cytometric study, the tumor was aneuploid (DNA Index = 1.3).
Seat Lumbar Support Evaluation With ASPECT Manikin (2005)

<div class="htmlview paragraph">Seat lumbar support is thought to be essential for seating comfort as it plays important role in the driver's fatigue during long term driving. We tried to evaluate the lumbar support performance objectively with Seat Pressure Distribution. First, the tolerance in the measurement was eliminated by application of ASPECT manikin that reproduced a human seating torso posture [<span class="xref">1</span>, <span class="xref">2</span>]. Second, an analysis method to visualize the seat support balance on the human back was developed. Third, a hypothesis for the optimal support balance to minimize the fatigue was proposed according to the fatigue growing mechanisms. Examining the deviation of each seat result from the optimal support, the performances were quantitatively evaluated. In addition to that, the effect of the lumbar support adjuster was taken into consideration to predict the market evaluation more precisely.</div>
Nonlinear electrical transport in nc-Si/CaF2 multilayer structures with ultrathin CaF2 layers (2001)

We present a study of the electrical transport in (Si/CaF2)n superlattices with n=100 and with Si, CaF2 thickness in each period in the range of 1.2–1.6 nm (Si) and below 1 nm (CaF2), respectively. The results suggest that at gate voltages higher than ±4 V a Poole–Frenkel-type mechanism accounts for the observed electric-field-assisted conduction through the layers.
ChemInform Abstract: Synthesis and Suzuki—Miyaura Cross‐Coupling of Enantioenriched Secondary Potassium β‐Trifluoroboratoamides: Catalytic, Asymmetric Conjugate Addition of Bisboronic Acid and Tetrakis(dimethylamino)diboron to α,β‐Unsaturated Carbonyl Compounds. (2014)

Abstract Enantioenriched title compounds are synthesized via a new asymmetric, copper‐catalyzed addition of tetrahydroxydiboron to various α,β‐unsaturated amides, ketones, and esters in high yields and enantioselectivities.
Einführung in CORBA (2005)

Die Common Object Request Broker Architecture (CORBA) ist ein Standard der Object Management Group (OMG) und definiert eine Kommunikation für verteilte Objekte. Die Struktur von CORBA wird durch das CORBA Referenzmodell verdeutlicht, welches aus folgenden Komponenten besteht (nach [OMG/CORBA] S. xxv):
Design and evaluation of biological activity of diazenecarboxamide-extended cisplatin and carboplatin analogues. (2013)

Construction of a library of structurally diverse diazenecarboxamide-extended cis-[Pt(2-picolyl-1,2,3-triazole)Cl2,] and cis-[Pt(propan-1,3-diamine)CBDCA] (CBDCA = 1,1 -cyclobutanedicarboxylate) complexes 1-4 is described. These compounds retain oxidative properties of parent diazenecarboxamides against glutathione as demonstrated by NMR spectroscopy and high resolution mass spectrometry experiments. Cytotoxic activity of 1-4 was investigated against human cervical carcinoma HeLa cells. Four library members were found to possess moderate cytotoxic activity. Some model compounds were also examined, returning [PtCl2L2] (L = 1-(2-picolyl)-4-phenyl-1H-1,2,3-triazole) as the most potent under this investigation with IC50 of 19.05 microM, comparable to that of cisplatin (IC50 = 16.3 microM).
ChemInform Abstract: HETEROCYCLIC β‐ENAMINO ESTERS, 15. THE ADDITION OF ETHYL 2‐AMINO‐4,5‐DIHYDRO‐3‐FURANCARBOXYLATES TO ACETYLENECARBOXYLATES (1976)

Abstract Umsetzung der Furancarbonsäureester (I) mit dem Acetylenmonocarbonsäureester (II) liefert die Furopyridin‐Derivate (III) und (IV) und die Cyclopropane (V); in absoluten Lösungsmitteln (Äther, Aceton, Toluol) werden bei der Reaktion von (Ia) zusätzlich die Oxepinderivate (VI) isoliert.
Treatment of Culture-Negative Skull Base Osteomyelitis (2006)

The above-described treatment regimen will result in a high cure rate and a short hospitalization period.
Automatic Sampling and Measurement of Surface Area of Pulverized Material (1969)

The trend in cement manufacturing is to larger production units, central control, finer cements, and a broader range of cement fineness. The availability of a continuous sensor of cement fineness can help to alleviate problems which have been emphasized by these trends. A system for measuring specific surface of pulverized materials, especially finished cement, has been developed. This system, combining a fluidized blender and an automatic permeability sensor, gives promise of substantial benefit in optimization of production and quality in finish grinding of Portland cement.
Isolation and identification of a tyrosyl peptide labeled by 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine at a GTP site of glutamate dehydrogenase (1984)

The fluorescent nucleotide analogue 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine (5'-FSB epsilon A) was shown previously to react at a GTP inhibitory site on bovine liver glutamate dehydrogenase. The incorporation was limited to 1.28 mol of reagent/mol of subunit and was attributed to 0.95 mol of modified tyrosine/mol of subunit and 0.33 mol of modified lysine/mol of subunit, quantitatively accounting for the total incorporation prior to acid hydrolysis [Jacobson, M. A., & Colman, R. F. (1983) Biochemistry 22, 4247-4257]. The specific tyrosyl peptide modified by 5'-FSB epsilon A has been isolated from a tryptic and chymotryptic digest of modified enzyme by gel filtration and reverse-phase high-performance liquid chromatography and characterized by amino acid and amino-terminal analysis. A unique residue, tyrosine-262, was identified as an essential amino acid within the GTP binding site. The stacked conformation of the fluorescent analogue when enzyme bound suggests that tyrosine-262 may be located in the region of the GTP site which binds the purine ring.
Palladium Catalysis for the Synthesis of Hydrophobic C-6 and C-2 Aryl 2‘-Deoxynucleosides. Comparison of C−C versus C−N Bond Formation as well as C-6 versus C-2 Reactivity (2001)

Suzuki-Miyaura cross-coupling of haloaromatic compounds with arylboronic acids provides a simple entry to biaryl systems. Despite its ease, to date, there are no detailed investigations of this procedure for deoxynucleoside modification. As shown in this study, a wide variety of C-6 arylpurine 2'-deoxyriboside (C-6 aryl 2'-deoxynebularine analogues) and C-2 aryl 2'-deoxyinosine analogues can be conveniently prepared via the Pd-mediated cross-coupling of arylboronic acids with the C-6 halonucleosides, 6-bromo- or 6-chloro-9[2-deoxy-3,5-bis-O-(tert-butyldimethylsilyl)-beta-D-erythro-pentofuranosyl]purine (1 and 2), and the C-2 halonucleoside, 2-bromo-O(6)-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine (3). Although bromonucleoside 1 proved to be a good substrate for the Pd-catalyzed Suzuki-Miyaura cross-couplings, we have noted that for several C-6 arylations, the chloronucleoside 2 provides superior coupling yields. Also described in this study is a detailed evaluation of catalytic systems that led to optimal product recoveries. Finally, a comparison of the C-C and C-N bond-forming reactions of deoxynucleosides is also reported. On the basis of this comparison, we provide evidence that C-N bond formation at the C-6 position, leading to N-aryl 2'-deoxyadenosine analogues, is more sensitive to the ligand used, whereas C-C bond-forming reactions at the same position are not. In contrast to the ligand dependency exhibited in C-N bond formation at the C-6 position, comparable reactions at the C-2 position of purine deoxynucleosides proceed with less sensitivity to the ligand used.
High‐pressure‐induced changes in bovine milk: a review (2006)

High‐pressure (HP) treatment of food products is a novel processing technique during which the product is treated in a vessel of suitable strength at a high pressure, generally in the range 100–1000 MPa. As a result, several constituents and properties of the treated product are altered. HP‐induced changes in the constituents and properties of milk are arguably among the most extensive of the range of food products studied to date. HP treatment of milk induces solubilization of minerals associated with the casein micelles, denatures whey proteins and, depending on pressure, can either induce aggregation or disruption of the casein micelles. These HP‐induced changes in milk constituents affect the properties of the milk; cheesemaking properties of milk can be enhanced considerably, indicating potential application of HP treatment in this area; furthermore, encouraging results have also been reported for HP treatment of milk prior to yogurt manufacture. HP treatment of milk also affects its microflora; however, considerable variation in baroresistance between bacterial species and strains exists. Further applied research appears warranted to establish the full commercial potential of HP treatment of milk.