gebhart/patrepeval huggingface dataset:
Specific integrin α and β chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms (2005)

Integrins are adhesion receptors that are crucial to the functions of multicellular organisms. Integrin-mediated adhesion is a complex process that involves both affinity regulation and cytoskeletal coupling, but the molecular mechanisms behind this process have remained incompletely understood. In this study, we report that the phosphorylation of each cytoplasmic domain of the leukocyte function-associated antigen-1 integrin mediates different modes of integrin activation. alpha Chain phosphorylation on Ser1140 is needed for conformational changes in the integrin after chemokine- or integrin ligand-induced activation or after activation induced by active Rap1 (Rap1V12). In contrast, the beta chain Thr758 phosphorylation mediates selective binding to 14-3-3 proteins in response to inside-out activation through the T cell receptor, resulting in cytoskeletal rearrangements. Thus, site-specific phosphorylation of the integrin cytoplasmic domains is important for the dynamic regulation of these complex receptors in cells.
Blueprints for ETL workflows (2005)

Abstract. Extract-Transform-Load (ETL) workflows are data centric workflows responsible for transferring, cleaning, and loading data from their respective sources to the warehouse. Previous research has identified graphbased techniques that construct the blueprints for the structure of such workflows. In this paper, we extend existing results by explicitly incorporating the internal semantics of each activity in the workflow graph. Apart from the value that blueprints have per se, we exploit our modeling to introduce rigorous techniques for the measurement of ETL workflows. To this end, we build upon an existing formal framework for software quality metrics and formally prove how our quality measures fit within this framework. 1.
Mechanics of Electronic and Electromechanical Devices (1985)

Problems involving the interaction of electromagnetic material effects and forces with stresses, deformations, and dynamics span a wide spectrum from thermal strain problems in microelectronic chips to stresses in large superconducting magnets for fusion reactors, NMR scanners, and levitated trains. An important class of problems that merits increased research effort are the mechanics problems associated with transducers or sensors based on ferroelectric, ferromagnetic, semiconductor, or microelectronic materials. Another area which may have technological payoff is that of electromechanical actuators. Further work is also required on numerical methods for calculating electromagnetic fields, forces, torques, and currents in order to allow engineers to better design and optimize electromagnetic devices. Interaction of laser radiation and high energy particles with solids is another area for new research. Progress in this field has not been steady. The interdisciplinary nature of these problems has meant that the field has no natural home for funding. This will present a problem for future progress in this field.
Phase-Sensitive Amplified Transmission Links for Improved Sensitivity and Nonlinearity Tolerance (2014)

In this paper, we investigate the properties of transmission links amplified by phase-sensitive amplifiers (PSAs). Using an analytic description, we explain the principles enabling improved sensitivity compared to conventional links amplified by phase-insensitive amplifiers (PIAs) and mitigation of nonlinear transmission distortions. We demonstrate these features using numerical simulations, and in particular, we show the possibility of efficiently mitigating both self-phase modulation (SPM)-induced distortions and nonlinear phase noise (NLPN) if the link dispersion map is optimized. The properties of the noise on signal and idler are important and to enable NLPN mitigation, the noise must be correlated at the link input. We investigate the role of the dispersion map in detail and show that in a link with standard single mode fiber (SSMF) the optimum dispersion map for efficient nonlinearity mitigation corresponds to precompensation of an amount equal to the effective loss length. Furthermore, we experimentally demonstrate both improved sensitivity and mitigation of nonlinearities in a 105 km PSA-amplified link transmitting 10 GBd 16-ary quadrature amplitude modulation (16QAM) data. We measure a combined effect allowing for more than 12 dB larger span loss in a PSA-amplified link compared to a conventional PIA-amplified link to reach the same bit error ratio (BER) of 1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> .
New detector for ion-exchange chromatography (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew detector for ion-exchange chromatographyT. W. Gilbert and Richard A. DobbsCite this: Anal. Chem. 1973, 45, 8, 1390–1393Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://doi.org/10.1021/ac60330a008RIGHTS & PERMISSIONSArticle Views89Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (488 KB) Get e-Alerts Get e-Alerts
Noise-Domain Reflectometry for Locating Wiring Faults (2005)

Reflectometry is commonly used to determine the integrity of cables and wiring. This work describes a new family of reflectometers, the noise-domain reflectometers (NDR), that uses existing data signals on wiring and does not need to generate any signals of their own. There are two types of NDR, type I (where incident and reflected signals are separated) and type II (where they are superimposed). NDR is totally "quiet" and passive to other signals on the media. Especially for NDR II, detection can be done totally nonintrusively. In this paper, the working principles of NDR are described. Simulation results and examples for location of faults to within 3 inches on wiring up to 180 feet are provided.
A Codominant Role of FcγRI/III and C5aR in the Reverse Arthus Reaction (2000)

Recent attempts to specify the relative contribution of FcR and complement in various experimental systems of immune complex disease have led to opposing conclusions. As concluded in IgG FcRgamma-/- mice, manifestation of disease is almost exclusively determined by FcgammaR on effector cells, arguing for a minor role of complement. In contrast, data obtained with C5aR-/- mice suggested that, dependent on the tissue site, complement is more important than FcgammaR. In this paper, we demonstrate that, in response to IgG immune complex formation, FcgammaRI/III- and C5aR-mediated pathways are both necessary and only together are they sufficient to trigger the full expression of inflammation in skin and lung. Moreover, both effector systems are not entirely independent, suggesting an interaction between FcgammaR and C5aR. Therefore, FcgammaR-mediated responses can be integrated through C5aR activation, which may explain why these two receptor pathways have previously been considered to dominate each other.
Changes in nitrogen metabolism in sweet potato with black rot (1961)

Although recent studies on changes in nitrogen metabolism in diseased plants have accumulated, their relationship to resistance or susceptibility is still ambiguous. Rohringer (21), and Shaw and Colotelo (24) reported differences in free amino acids between wheat (Triticum1t aestizvmo) infected by P2uccinia gramiiiuis and the healthy plant. Rohringer, Stah- mann, and Walker (23) found that following infec- tion of tomato (Lvlcopcrsicoil esculentnim) leaves by Fusariun oxv,spormn f. lycopersici, amino acids, and other ninhydrin positive compounds were changed in concentration in the susceptible variety, in contrast to little change in the resistant one, though the change may not be a specific response to infection. Uritani (37) observed a decrease in asparagine in sweet po- tato roots (Ipomiiea bataltas) infected by Ceratocustis finiibriiata, and Suzuki et al. (
Response of Arterial Wall to Intramural Cholesterol. (1958)

SummaryA technic is described for study of response of avian arteries to intramural injection of cholesterol. This material, when injected into the wall of the artery, causes a foreign body reaction at site of injection. In addition, a localized proliferation of collagenous connective tissue is found in the intima. These intimal plaques resemble some forms of human atherosclerosis. The development of the plaques is not affected by adding cholesterol or various fats to the diet. These findings suggest that the lesions are the result of the local metabolic alteration.
Transparent and conductive Ga-doped ZnO films grown by low pressure metal organic chemical vapor deposition (1997)

Highly transparent conductive Ga-doped zinc oxide (ZnO:Ga) has been deposited on 3 in.×4 in. Corning 7059 glass and other substrates using a high speed rotating disk reactor low pressure metal organic chemical vapor deposition system. Diethylzinc, oxygen, and triethylgallium were used as precursors. The films exhibit low resistivity, ∼2.6×10−4 Ω cm, high optical transparency (&gt;85%) in the visible range, good adhesion, and are highly stable. The film properties were correlated with the growth conditions, including flow rate, temperature, pressure, and doping concentrations. The microstructural properties of the films, such as surface and interface morphology, crystallinity, and composition were studied using scanning electron microscopy, x-ray diffraction, and secondary ion mass spectroscopy. The resistivity and transmittance of the films were investigated by four-point probe measurements, photoluminescence spectroscopy, and optical absorption spectroscopy. In order to meet the needs for application to flat panel displays, the thermal stability of the Ga-doped ZnO films have been tested by a dc biased heater. The feasibility of film processing was also investigated through patterning and wet chemical etching.
Performance of OFDM-CDMA Overlay Systems Considering Inaccurate Allocation Vectors (2005)

In this paper, we investigate an OFDM-CDMA overlay system. It has to continuously monitor the licensed system's frequency allocations and broadcast the used subchannels to all overlay terminals. In order to reduce the signaling overhead we study the effects on system performance when the receiver is using an inaccurate allocation vector. From these results we derive criteria by which the transmitter can decide whether or not it is necessary to broadcast an update of the allocation vector.
Secretion of Both IL-2 and IL-4 by Tumor Cells Results in Rejection and Immunity (1996)

The generation of a therapeutic immune response to malignancy is critically dependent on the inherent immunogenicity of the tumor. Our study demonstrates that secretion of both interleukin-2 (IL-2) and IL-4 by a seemingly nonimmunogenic tumor abrogates tumorigenicity, and mice that have rejected the genetically modified tumor are immune to challenges with the parental tumor. The induction of immunity by the IL-2/IL-4-secreting tumor was significantly better than that achieved with the admixture of tumor cells and the classic adjuvant, Corynebacterium parvum. To elicit a primary immune response, the majority of cells needed to secrete both cytokines. Ad-mixture of IL-2-secreting cells with IL-4-secreting cells did not result in tumor cell rejection. The IL-2/IL-4-secreting tumor cells were efficiently rejected in animals immunosuppressed by total body irradiation. Depletion of CD4+ or CD8+ T cells did not abrogate rejection of the tumor cells, but the animals depleted of CD4 cells failed to generate protective immunity. Our study demonstrates that secretion of the combination of IL-2 and IL-4 significantly enhances tumor immunogenicity. The requirement of cells secreting both cytokines suggests an intricate mechanism different from the mere presence of both cytokines at the tumor-inoculation site.
Quantitative sonographic feature analysis of clinical infant hypoxia: a pilot study. (1996)

Quantitative sonographic textural feature analysis showed differences between the brains of healthy infants and those of infants with clinical hypoxia.
Speech modeling with time varying amplitude and phase (2002)

Formant transitions contain important information related to hearing and perception. The concept of moving poles is used in this paper in relation to the time-varying impulse response model of the vocal tract and describes the trajectory of a formant. The model allows for amplitude modulation as well as other nonstationarities present such as formant bandwidth variations. The moving poles are modeled as polynomial functions of time, whose linear (albeit suboptimal) estimates ate obtained from the higher-order ambiguity function. An overall optimal but nonlinear least squares scheme is developed to improve upon the linear estimates and both algorithms are tested by simulations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Numerical Washout Study of a Pulsatile Total Artificial Heart (2014)

Bileaflet MHVs were demonstrated to be only slightly sensitive to rotation regarding the washout performance of the TAH. The proposed numerical washout model proved to be an adequate tool to quantitatively compare different configurations and designs of the artificial organ regarding the potential for blood stagnation where experimental measurements are limited.
Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival (2015)

The identification of pathways necessary for photoreceptor and retinal pigment epithelium (RPE) function is critical to uncover therapies for blindness. Here we report the discovery of adiponectin receptor 1 (AdipoR1) as a regulator of these cells' functions. Docosahexaenoic acid (DHA) is avidly retained in photoreceptors, while mechanisms controlling DHA uptake and retention are unknown. Thus, we demonstrate that AdipoR1 ablation results in DHA reduction. In situ hybridization reveals photoreceptor and RPE cell AdipoR1 expression, blunted in AdipoR1(-/-) mice. We also find decreased photoreceptor-specific phosphatidylcholine containing very long-chain polyunsaturated fatty acids and severely attenuated electroretinograms. These changes precede progressive photoreceptor degeneration in AdipoR1(-/-) mice. RPE-rich eyecup cultures from AdipoR1(-/-) reveal impaired DHA uptake. AdipoR1 overexpression in RPE cells enhances DHA uptake, whereas AdipoR1 silencing has the opposite effect. These results establish AdipoR1 as a regulatory switch of DHA uptake, retention, conservation and elongation in photoreceptors and RPE, thus preserving photoreceptor cell integrity.
Measurements of a VLSI design (1982)

This paper presents data about three facets of a rec ently-completed VLSI design containing 45000 transistors. The first set of data describes the masklevel features of the circuit, from which it is seen that almost all features have at least one small dimension. The second set of data analyzes the hierarchical cell structure used by the designers to specify the circuit. The measurements show that composite ceils have a different structure from primitive ceils, and that, outside of arrays, cells are rarely re-used. The third set of data concerns the usage of an interactive layout program during the circuit's design. In spite of the circuit's size, the most frequently invoked commands were all simple.
Kinetics of nucleophilic addition to co-ordinated cyclobutadiene (1977)

A kinetic study in acetone of the equilibrium addition of tris-(p-chlorophenyl)phosphine to the cyclobutadiene ring in cyclobutadienedicarbonylnitrosyliron hexafluorophosphate suggests that the mechanism of addition does not involve initial attack at the metal.
A new super-rapid pulse power charging electric scooter system with balancer-less EDLC stack (2017)

This work is focused upon power electronic motor-driven scooter with a new EDLC (Electric Double Layer Capacitor) on board charger. This electric scooter is eco-friendly and high performances. In addition, it is effective method suitable for global environmental issues and energy concerned problems. This paper mainly deals with an EDLC based-electric scooter and its unique super-rapid pulse charging system. The useful results of design procedure and prototype performance evaluations have been carried out and discussed in this paper.
Ultrafast Optical TDM Networking: Extension to the Wide Area (1999)

this paper we discuss these challenges and describe progress made in both architecture and technologies required for scaling HLAN to the wide area.
Clinical and cytogenetic analysis of an intracranial inflammatory myofibroblastic tumor induced by a ventriculoperitoneal shunt (2009)

The authors report the first case of an intracranial inflammatory myofibroblastic tumor (IMT) associated with the placement of a ventriculoperitoneal shunt, which occurred in a 7-year-old boy. Neuroradiological features showed a mass surrounding the ventricular catheter. The lesion was completely resected. Histological study revealed the mass to be an IMT. The patient's postoperative course was complicated by a local recurrence requiring a second surgery. Cytogenetic analysis of the sample by comparative genome hybridization revealed several chromosomal amplifications and regional losses. The occurrence of IMT in the CNS has rarely been reported. For treatment of this condition, the authors recommend a total removal of the shunt with a mass excision to prevent local recurrence.
Controlling Double Vortex States in Low-Dimensional Dipolar Systems (2009)

The reversal process of the chirality of each opposite vortex belonging to a double vortex state in ferromagnetic hysterons, via the application of in-plane magnetic fields, is reported. Simulations reveal that such a process involves the formation of four intermediate states, including original ones. Hysteresis loops can occur only in a counterclockwise fashion because of one of these intermediate states. Double vortex states can also be controlled by electric fields in ferroelectric nanostructures of different shapes, but with some key differences with respect to the ferromagnetic case.
Role of Granulocyte-Macrophage Colony Stimulating Factor Secretion in the Biologic Effects of Adoptive Cellular Immunotherapy of Patients With Colorectal Cancer (1995)

KIM, JULIAN; MARTIN, EDWARD; HEFFELFINGER, MARILYN; ALDRICH, WAYNE; TRIOZZI, PIERRE Author Information
Basic technique in endoscopic ultrasound-guided fine needle aspiration for solid lesions: What needle is the best? (2014)

Basic technique for endoscopic ultrasound (EUS) of solid lesions has developed during 30 years of EUS, as endoscopes and accessory equipment, particularly needles, have been developed. Systematic high-quality examinations require understanding and planning. Needles used for EUS-guided fine needle aspiration (FNA) have gone through many improvements; some 18 characteristics of any needle are presented and these come under consideration whenever choosing the best needle for each procedure. The bright future of EUS and FNA for solid lesions currently still leaves much room for continued developments.
Prestack waveform inversion of the East Texas Woodbine Gas Sands using a genetic algorithm (1996)

Genetic Algorithm (GA) is a Monte-Carlo type inversion technique utilizing the analogy of the biological evolution of chromosomes in directing its random search process. An outline of GA as applied to prestack waveform inversion is given in Mallick (1995).
A generic architecture for programmable traffic shaper for high-speed networks (1995)

Traffic shapers by preventing congestion and smoothing the traffic, play an important role in realizing the traffic control schemes employed in high speed networks to ensure the Quality of Service (QoS) requirements of the application. In this report, we present a generic architecture for programmable traffic shaper for high speed networks. The programmability of the proposed architecture is illustrated by implementing some of the existing traffic shaping schemes. The architectural design issues of the proposed scheme are described and discussed. 1 Introduction Network applications with real-time constraints and high bandwidth requirements such as distributed multimedia applications are made feasible with the advent of Asynchronous Transfer Mode (ATM) networks [10]. The call admission control (CAC) functions of ATM network and the associated protocols allow the applications to specify the traffic characteristics as well as quality of service (QoS) requirements at the call setup time. ...
Unconventional Route to Uniform Hollow Semiconducting Nanoparticles with Tailorable Dimensions, Compositions, Surface Chemistry, and Near‐Infrared Absorption (2017)

Abstract Despite impressive recent advances in the synthesis of lead chalcogenide solid nanoparticles, there are no examples of lead chalcogenide hollow nanoparticles (HNPs) with controlled diameter and shell thickness as current synthetic approaches for HNPs have inherent limitations associated with their complexity, inability to precisely control the dimensions, and limited possibilities with regard to applicable materials. Herein, we report on an unconventional strategy for crafting uniform lead chalcogenide (PbS and PbTe) HNPs with tailorable size, surface chemistry, and near‐IR absorption. Amphiphilic star‐like triblock copolymers [polystyrene‐block‐poly(acrylic acid)‐block‐polystyrene and polystyrene‐block‐poly(acrylic acid)‐block‐poly(3,4‐ethylenedioxythiophene)] were rationally synthesized and exploited as nanoreactors for the formation of uniform PbS and PbTe HNPs. Compared to their solid counterparts, the near‐IR absorption of the HNPs is blue‐shifted owing to the hollow interior. This strategy can be readily extended to other types of intriguing low‐band‐gap HNPs for diverse applications.
Undersampled digital holographic interferometry (2008)

In digital holography, primary holographic fringes are recorded using a matricial CCD sensor. Because of the low spatial resolution of currently available CCD arrays, the angle between the reference and object beams must be limited to a few degrees. Namely, due to the digitization involved, the Shannon's criterion imposes that the Nyquist sampling frequency be at least twice the highest signal frequency. This means that, in the case of the recording of an interference fringe pattern by a CCD sensor, the inter-fringe distance must be larger than twice the pixel period. This in turn limits the angle between the object and the reference beams. If this angle, in a practical holographic interferometry measuring setup, cannot be limited to the required value, aliasing will occur in the reconstructed image. In this work, we demonstrate that the low spatial frequency metrology data could nevertheless be efficiently extracted by careful choice of twofold, and even threefold, undersampling of the object field. By combining the time-averaged recording with subtraction digital holography method, we present results for a loudspeaker membrane interferometric study obtained under strong aliasing conditions. High-contrast fringes, as a consequence of the vibration modes of the membrane, are obtained.