gebhart/patrepeval huggingface dataset:
Rats can predict aversiveness of Active Pharmaceutical Ingredients (2018)

Taste is crucial for patient acceptability and compliance with prescribed medicines, in particular with pediatric patients. Evaluating the taste of new active pharmaceutical ingredients (APIs) is therefore essential to put in place adequate taste-masking techniques, if needed, which will lead to acceptable palatable formulations. Thus, there is an urgent need to develop and optimize taste assessment methods that could be used at different stages of the drug development process. The aim of this study was to investigate the suitability of the rat brief-access taste aversion (BATA) model as a screening tool for assessment of APIs aversiveness that could predict human taste responses. Presently, the taste intensity of nine marketed APIs known to have different levels of bitter intensity (quinine hydrochloride dihydrate, 6-n-propylthiouracil, sildenafil citrate, diclofenac sodium, ranitidine hydrochloride, caffeine citrate, isoniazid, telbivudine and paracetamol) was investigated at different overlapping concentrations with two in vivo taste assessment methods: the rat BATA model and human taste panels with the intention of determining the drugs' concentrations to produce half of the maximal rating. Overall there was a strong correlation (R<sup>2</sup> = 0.896) between rats IC<sub>50</sub> and humans EC<sub>50</sub> values. This correlation verifies the BATA model as a rapid and reliable tool for quantitative assessment of API aversiveness. A comparable ranking order was obtained mainly for high and medium aversive compounds, whereas it was less aligned for weakly aversive compounds. It was nonetheless possible to propose a classification of poor taste intensity determined in rats that would predict human taste tolerability.
Detection of irregular patterns of myocardial contraction in patients with hypertensive heart disease (2011)

In conclusion, LVH in patients with arterial hypertension predominantly affected longitudinal and circumferential deformation rate. Moreover, LVH resulted in a significant reduction of systolic twist rate and diastolic untwist rate, whereas overall left ventricular twist angle was not influenced by LVMH.
State-identification experiments and testing of sequential circuits (2009)

In this chapter, we shall be concerned with experimental analysis of the behavior of finite-state machines, test generation for sequential circuits, design for testability, and built-in self-test (BIST).
Checking Out HUD's Proposed Mobile Home Performance Standards (1993)

Researchers at the National Renewable Energy Laboratory measured the thermal performance of two mobile homes built to meet recently proposed federal energy performance standards. This article discusses how the homes--and the standards themselves--measure up.
Distraction‐focused interventions on examination stress in nursing students: Effects on psychological stress and biomarker levels. A randomized controlled trial (2019)

Our preliminary findings suggest positive but situation-dependent effects of distraction-focused interventions in academic settings. Further research should investigate the complex relationship between physiological and psychological stress parameters.
TRUST (2006)

There is an alarming increase in the number of virus and worm attacks, phishing emails, identity theft both on the internet and physical infrastructures. Indeed, cyberspace has several features of lawlessness which make it difficult for us to mirror societal trust relationships into cyberspace. A cursory examination of the issues involved in an issue like phishing or electronic voting reveals that the problems that we are confronting have both a technology and a policy component. Further, with our increase dependency on computing and communication to instrument physical infrastructures, such as electric power, water, gas, etc. we find that they are vulnerable to information attack as well. To address these grand challenge societal problem, in June 2005, the NSF has established a Science and Technology Center entitled "TRUST: Team for Research in Ubiquitous Secure Technologies" between Berkeley (lead), CMU, Cornell, Stanford and Vanderbilt with outreach partners at San Jose State, Mills and Smith College. In this talk, I will give you a snap shot of the kinds of research, education, technology transfer, privacy and policy work that we have underway. Rather than present a smorgasbord of work at the Center I will give a selected few examples of the work, technology transfer and impact that the Center has already had in the area of network embedded systems:
Antimicrobial and Cytotoxic Activity of Some Medicinal Plants from Baja California Sur (Mexico) (2001)

AbstractScientific evaluation of 25 ethanol extract of plants used in the traditional medicine of Baja California Sur (Mexico) were tested for microbial and HCT-116 cell growth inhibition. Ten extracts showed activity against the HCT-116 cell line, notably Asclepias subulata (Asclepiadaceae), Aristolochia brevipes (Aristolochiaceae) and Bursera odorata (Burseraceae). Haplopappus sonorensis (Asteraceae) Asclepias subulata and Bursera odorata inhibited Mycobacterium tuberculosis by 40, 45 and 67%, respectively, at a concentration of 100 µg/mL. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis, Candida albicans and Escherichia coli was determined, and Aristolochia monticola, A. brevipes, Hymenoclea monogyra and Hymenoclea sp. were found to be the most active. Xanthium strumarium showed low activity against C. albicans.
Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for<i>in vivo</i>HER-2 receptor-targeted imaging (2018)

We developed highly bright and stable far-red emissive AIEdots by using a new kind of click-functional PEG grafted amphiphilic polymer to coat hydrophobic AIE-active polymers (PDFDP). Furthermore, an anti-HER2 recombinant fully human antibody was produced and conjugated on the AIEdots via metal-free click chemistry to fabricate in vivo tumor-targeting nanoprobes.
(2<i>S</i>)-2-Benzyl-1-[(4<i>R</i>)-4-benzyl-2,2-dimethyl-1,3-oxazolan-3-yl]pent-4-en-1-one (2006)

The title compound, C24H29NO2, is one of the inter­mediates of the potent HIV protease inhibitor Indinavir. The oxazolidine ring adopts an envelope conformation. The orientation of the benzyl groups facilitates C—H⋯π inter­actions, forming mol­ecular chains along the a axis.
A Comprehensive Review on Electrohydrodynamic Drying and High-Voltage Electric Field in the Context of Food and Bioprocessing (2012)

Abstract Increasing global energy demand and the application of more energy-consuming processes has forced food industries to investigate alternative processes. This article pertains to one such novel and promising alternative drying process called electrohydrodynamic (EHD) drying. EHD is a method of inducing electric wind that is generated by gaseous ions under the influence of a high-voltage electric field. This article evaluates the available literature and discusses the experimental investigations carried out to explain the effect of operating parameters on the drying rate and specific energy consumption (kJ/kg water) of the EHD process. Through the review it was established that the corona current increased linearly with an increase in applied voltage (kV) for both positive and negative polarities and a negative corona discharge produced a larger corona current compared to a positive corona discharge. It was also revealed that the specific energy consumption increased with an increase in applied voltage for both polarities but was lower compared to conventional drying processes such as fluidized bed drying; however, it was observed that the specific energy consumed by the EHD process was lower than that of latent heat of vaporization, indicating the removal of water from the surface of the sample by other means in addition to evaporation. Electrode configuration plays an important role in determining the efficiency of the EHD process; the multiple-needle electrode configurations had better efficiency than wire and single-electrode configurations. Recent and past studies on application of EHD both postharvest and in food processing were also reviewed and the benefit of using EHD for food and bioprocessing due to its unique properties supported the feasibility and applicability of EHD as a suitable alternative for processing thermally sensitive biological materials. Keywords: Corona dischargeElectrode configurationElectrohydrodynamicsFluidized bed dryingFood processingSpecific energy consumption ACKNOWLEDGMENTS The authors are grateful to the Natural Sciences and Engineering Research Council of Canada and Fonds Quebecois de la Recherche sur la Nature et les Technologies for financial support of this study.
A novel dendritic cell subset supporting the concept of tumor immunoediting: IFN producing Killer Dendritic cell (IKDC) (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4874 

IFNγ is a key immunomodulator pivotal in the host defense against tumor progression. Pionnering studies have demonstrated that IFNγ mediated-signaling pathways are critical against tumor development in recombination activation gene deficient mice. Here we show that the main source of IFNγ is not the conventional NK cell but a subset of B220+Ly6C- dendritic cells that are atypical in thus far that they express NK cell surface molecules (Dx5, NK1.1, NKG2D, Ly49). They represent 1% of splenic CD11c+ cells in naive animals, can be expanded by 5 fold by immunotherapy combining c-kit tyrosine kinase inhibitors and IL-2 or Flt3L and traffick into tumor beds where they constitute up to 20% of tumor infiltrating CD11c+. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220+NK1.1+ dendritic cells secrete high levels of IFNγ and mediate TRAIL-dependent tumor cell lysis. During therapy with imatinib mesylate and IL-2, tumor regression depends on TRAIL molecules, NK1.1 expressing cells and IFN type II receptors, suggesting a role for B220+NK1.1+ dendritic cells in tumor shrinkage. Adoptive transfer of these Interferon-producing Killer Dendritic Cells (IKDC) into tumor-bearing Rag-/-IL-2Rγ-/- mice prevented tumor outgrowth whereas conventional NK cells failed to do so. IKDC can be found in Rag-/-IL-2Rγ-/- mice, they diverge from the NK cell lineage. Moreover, they exhibit a typical morphology distinguishable from classical myeloid DC or plasmacytoid DC or NK cells and are capable of antigen presentation following TLR4 and 9 triggering. We identified IKDC as pivotal sensors and effectors of the innate anti-tumor immune response (Taieb J et al Nature Medicine, in revision in back to back with D.Pardoll’s manuscript).
A Recognition System for Multiple Mobile Robots Using RFID System in Smart Space (2010)

This paper deals with the recognition of multiple mobile robots equipped with RFID tag. In the case that the number of robots recognized by each RFID reader is larger than that of allocated slots, the clashing recognition occurs. And, in the case that the total number of robots recognized by all RFID reader is larger than that of real robots, the repetitious recognition occurs. We employ the dynamic frame slot allocation by using the ALOHA algorithm to prevent the clashing recognition and estimate the number of robots by using the received signal strength indication to prevent the repetitious recognition. The numerical experiment shows the reliability and the efficiency of the proposed method.
Direct Determination of Large Spin-Torque Nonadiabaticity in Vortex Core Dynamics (2010)

We use a pump-probe photoemission electron microscopy technique to image the displacement of vortex cores in Permalloy discs due to the spin-torque effect during current pulse injection. Exploiting the distinctly different symmetries of the spin torques and the Oersted-field torque with respect to the vortex spin structure we determine the torques unambiguously, and we quantify the amplitude of the strongly debated nonadiabatic spin torque. The nonadiabaticity parameter is found to be β=0.15±0.07, which is more than an order of magnitude larger than the damping constant α, pointing to strong nonadiabatic transport across the high magnetization gradient vortex spin structures.
Dominant negative mutants of Myc inhibit cooperation of both Myc and adenovirus serotype-5 E1a with Ras (1996)

We have used dominant negative Myc mutants to analyze the Myc and E1a mechanisms of cooperation with Ras. We show that mutants of Myc with an altered basic region (BR; RR366, 367EE) or deletion of the leucine zipper (LZ; delta aa 414-439), changes which modify the DNA binding domain, or with deletions in the Myc amino terminal conserved regions box 1 (dlMB1; delta aa 46-55) and box 2 (dlMB2; delta aa 132-140) inhibit cooperation of wt Myc and activated Ras to transform rat embryo fibroblasts (REF). Expression of the amino terminal 104 aa had no effect whereas wt Myc stimulated focus formation. Mutant dlMB1 cooperated with Ras with one half wt efficiency while dlMB2 was inactive. No mutant tested was toxic during neomycin cotransformation of REF to G418 resistance. Interestingly, these Myc mutants exerted a parallel inhibition of E1a-Ras cooperation to transform REF. This suggests that the Myc-Ras and E1a-Ras cooperation pathways intersect and require common protein factors. A Myc box 2 deletion mutant which is a wt transactivator of the Myc responsive ornithine decarboxylase promoter, but unlike the wt does not repress the adenovirus-2 core promoter (Li et al., 1994, EMBO J., 13:4070-4079), inhibits Myc-Ras and E1a-Ras cooperation. This suggests that a box 2-dependent step, potentially gene repression, is required for both the E1a- and Myc-Ras cooperation mechanisms.
Hip, hype and hope---the three faces of virtual worlds (panel session) (1990)

By now, almost everyone in computer graphics has read, seen, or experienced virtual worlds--"artificial realities" generated by computers which surround the user. Virtual.world systems are the focus of the media, grist for the TV mill, and everyone's pick as "The Big Idea of the 90s." But what does it all mean? Is virtual-worlds technology really that important? Panelists address the artificial reality controversy and suggest the filture of professional and personal computer use. Hip, Hype and Hope: The Three Faces of Virtual Worlds 10-1 Hip, Hype and Hope: The Three Faces of Virtual Worlds 10,"3 Hip, Hype and Hope: The Three Faces of Virtual Worlds 10-5 .L-~.< ....
An Interaction between Praseodymium 4-Hydroxycinnamate with AS1020 and X65 Steel Microstructures in Carbon Dioxide Environment (2018)

This work reports on the application of a rare earth organic compound, praseodymium 4-hydroxycinnamate - Pr(4OHCin)3, as an effective inhibitor suitable for preventing carbon dioxide corrosion of steels in an aggressive environment. Two steels, namely an AS1020 and a X65 steel, have been tested in 0.01 M NaCl solution saturated with carbon dioxide gas using electrochemical and surface analysis techniques. The results show that X65 steel is less susceptible to corrosion than AS1020 steel in CO2-saturated 0.01 M NaCl solution as indicated by a lower corrosion current density and a higher polarization resistance. On the other hand, the AS1020 was inhibited much more effectively by praseodymium 4-hydroxycinnamate compound in comparison with X65 steel, as the corrosion behavior of AS1020 and X65 steels was similar in the presence of the inhibitor. However, the inhibiting effects on the anodic reaction was greater for AS1020 due to a reduction in the anodic current density in comparison with X65 steel. The dramatic effect of praseodymium 4-hydroxycinnamate compound could be attributed to the protective inhibiting deposits and enhanced film formation on the more active steel surface.
Thrombopoietin: Biology, clinical applications, role in the donor setting (1996)

Thrombopoietin (c-Mpl ligand) is the hematopoietic growth factor that is responsible for regulating the production of platelets from bone marrow megakaryocytes. This approximately 90 kd protein has recently been isolated and is comprised of an erythropoietin domain that is approximately 50% homologous to erythropoietin and a carbohydrate domain that is highly glycosylated and appears to stabilize the protein in the circulation. Thrombopoietin is produced in the liver and blood levels are determined by the mass of circulating platelets. However, there is no platelet "sensor." Rather platelets contain high affinity thrombopoietin receptors that bind and remove thrombopoietin from the circulation and thereby directly determine circulating levels. In vitro thrombopoietin stimulates both early and late megakaryocyte precursors as well as some erythroid and multipotential progenitor cells. When administered to normal animals, it stimulates platelet production up to six-fold without affecting other lineages. However, when given to animals following chemotherapy or irradiation, it stimulates erythroid and myeloid as well as platelet recovery. Several different recombinant thrombopoietin proteins are now entering clinical trials in humans and all preliminary reports confirm a potent thrombopoietic stimulus and apparent lack of toxicity. Thrombopoietin shows great promise in preventing the thrombocytopenia associated with chemotherapy, bone marrow transplantation, and other acute or chronic thrombocytopenic disorders. In transfusion medicine, thrombopoietin may help mobilize peripheral blood progenitor cells, stimulate donors for plateletpheresis, and enhance platelet survival and function during storage, Many studies are currently underway in all these areas and should soon establish the role of thrombopoietin in clinical medicine.
Metal−Alkane Complexes. Rapid Exchange of Hydrogen Atoms between Hydride and Methyl Ligands in [(C<sub>5</sub>Me<sub>5</sub>)Os(dmpm)(CH<sub>3</sub>)H<sup>+</sup>] (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMetal−Alkane Complexes. Rapid Exchange of Hydrogen Atoms between Hydride and Methyl Ligands in [(C5Me5)Os(dmpm)(CH3)H+]Christopher L. Gross and Gregory S. GirolamiView Author Information School of Chemical Sciences, The University of Illinois at Urbana-Champaign, 601 South Goodwin Urbana, Illinois 61801 Cite this: J. Am. Chem. Soc. 1998, 120, 26, 6605–6606Publication Date (Web):June 20, 1998Publication History Received25 August 1997Revised21 April 1998Published online20 June 1998Published inissue 1 July 1998https://pubs.acs.org/doi/10.1021/ja972971thttps://doi.org/10.1021/ja972971trapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views500Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Anions,Hydrogen,Ligands,Resonance structures Get e-Alerts
<title>Alternative methods for wavelength determination: interference filters and double photodiodes</title> (1999)

Wavelength measurements with Michelson interferometers have major disadvantages of high costs and low measurement rates. The paper shows two alternative method for wavelength measurement: one based on interference filters, the other based on double photodiodes. Interference filters are made of several optically transparent layers with different refraction indices. Within a certain wavelength range transmittance and reflectivity of the interference filter change constantly with the laser wavelength. Therefore, after calibration measurements, the wavelength can be obtained within milliseconds with a resolution of approximately plus or minus 0.01 nm by measuring the intensity of both the transmitted and the reflected beam. Double photodiodes are a combination of two single photodiodes with different spectral sensitivities in one case. Within a specified wavelength range both sensitivities are linear but have different gradients. Hence, by measuring the respective currents of each photodiode the wavelength can be obtained with a resolution of approximately plus or minus 0.1 nm also within milliseconds. Furthermore, the experimental set-up that is used for each method is illustrated, measurement results of both methods are presented, discussed and compared.
A New Luminescence Assay for Autoantibodies to Mammalian Cell–Prepared Insulinoma-Associated Protein 2 (2008)

The luciferase system offers a robust, inexpensive, nonradioactive method for the detection of autoantibodies to mammalian cell-prepared IA-2 and could be of practical value at the clinical level.
Ultrasound guided versus conventional joint and soft tissue fluid aspiration in rheumatology practice: a pilot study. (2002)

The use of US to localize joint and soft tissue fluid collection greatly improves the rate of diagnostic synovial fluid aspiration, particularly in small joints. This has important implications for accurate administration of local steroid therapy and emphasizes the importance of US as a useful tool in clinical rheumatological practice.
Identification of a candidate primary sex determination locus, <i>fox-1</i>, on the X chromosome of <i>Caenorhabditis elegans</i> (1994)

Sex in Caenorhabditis elegans (XX hermaphrodite, XO male) is determined by the X:A ratio, which is the ratio of X chromosome number to autosomal set number. Recent genetic results with X chromosome duplications have suggested that there may be only a small number of major numerator sites on the X chromosome that contribute to this ratio. Mapping of duplication endpoints delimited a region of less than 300 kb, likely to contain one such element. Cosmid clones from this region were tested for numerator activity by constructing transgenic lines carrying extra copies of each tested cosmid. Most cosmid arrays have no effect on the viability of either XX or XO animals. One cosmid array was found to be viable in XX animals, but lethal and feminizing in XO animals, consistent with it containing a major numerator element. Further experiments defined a region of 12-30 kb with apparent numerator activity, which is designated fox-1, 'Feminizing locus On X'. A cDNA clone hybridizing across part of this region encodes a predicted RNA-binding protein.