gebhart/patrepeval huggingface dataset:
Protein Phosphatase 2A Plays a Role in the Suckling-Induced Changes in the Responsiveness of Pituitary Mammotropes (1998)

It is well established that PRL secretion is under a tonic inhibition exercised by the hypothalamic dopamine (DA). One feature of this regulation is an immediate withdrawal reaction (elevation of PRL release) of mammotropes after disruption of hypothalamic influence. Although plasma PRL rises rapidly, the suckling stimulus does not cause an acute diminution of hypothalamic DA, but, as we have previously demonstrated, it results in an almost immediate (within 10 min) desensitization of mammotropes as indicated by the change in dose response of DA to inhibit PRL release. Our present investigations relate to the phenomenon of this change in responsiveness of PRL cells. This was accomplished by using the reverse hemolytic plaque assay to evaluate the secretory characteristics of individual PRL secretors derived from lactating rats either before or after a 10-min suckling stimulus. To investigate the mechanism of these changes, the binding characteristics of [3H]spiperone on pituitary membranes from nonsuckled and suckled rats have been compared, and the possible involvement of dephosphorylating enzymes was tested by using okadaic acid (OA) in a dose of 2 nm that preferentially and selectively inhibits protein phosphatase-2A (PP2A) activity. We have also determined the activities of PP1 and PP2A in pituitary tissue samples as well as in enzymatically dispersed cells. Mammotropes from nonsuckled rats exhibited a depression of PRL release after both DA and OA treatment and an elevation after withdrawal of DA. This suggests that the secretory response of mammotropes obtained from nonsuckled rats still shows those two responses that are characteristic of the tonic inhibitory regulation. In contrast, superimposition of suckling in vivo or application of OA together with DA pretreatment in cells from nonsuckled rats in vitro resulted in a disappearance of the dissociation-induced elevation of PRL release, indicating an abolishment of the tonic inhibitory action of DA. Evidence is also presented that the PP2A, but not the PP1, activity of the anterior lobe is significantly lower after a 10-min suckling stimulus. Moreover, DA is able to decrease PP2A activity in dispersed pituitary cells obtained from nonsuckled, but not from suckled, animals. In contrast, there were no differences in either the affinity or the number of binding sites between nonsuckled and suckled rats. Taken together, our results suggest that the suckling-induced decrease in PP2A activity plays a role in the uncoupling of D2 receptors on mammotropes from the tonic inhibitory signaling pathway.
[Study of the proteins associated with Sa antigen]. (2006)

Citrullinated vimentin is closely correlated with Sa antigen.
Using the ISIS resource manager for distributed, fault-tolerant computing (2002)

Under current versions of the UNIX operating system, it is difficult to take advantage of the massive computing power of idle or lightly loaded workstations on a network. The authors introduce the ISIS resource manager, a distributed fault-tolerant application capable of recapturing this processing power, as well as providing a transparent interface to network computing resources. They discuss the growing importance of high-speed workstation networks and the need for network management utilities and consider how advances in software technology have made it possible to easily construct a distributed fault-tolerant application to meet this need. The architecture of the resource manager is described as an example of this class of application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hydrothermal Synthesis and Structure of [(C2H5)4N][(VO)3(OH)(H2O)(C2H5PO3)3].cntdot.H2O. An Inorganic-Organic Polymer Exhibiting Undulating V/P/O Layers and Interlamellar Organic Templates (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrothermal Synthesis and Structure of [(C2H5)4N][(VO)3(OH)(H2O)(C2H5PO3)3].cntdot.H2O. An Inorganic-Organic Polymer Exhibiting Undulating V/P/O Layers and Interlamellar Organic TemplatesM. Ishaque Khan, Young-Sook Lee, Charles J. O'Connor, Robert C. Haushalter, and Jon ZubietaCite this: Chem. Mater. 1994, 6, 6, 721–723Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/cm00042a003https://doi.org/10.1021/cm00042a003research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Studies in Steroid Total Synthesis. III. Preparation of Cortisone and Compound F<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in Steroid Total Synthesis. III. Preparation of Cortisone and Compound F1Lloyd B. Barkley, Martin W. Farrar, William S. Knowles, and Harold RaffelsonCite this: J. Am. Chem. Soc. 1954, 76, 20, 5017–5019Publication Date (Print):October 1, 1954Publication History Published online1 May 2002Published inissue 1 October 1954https://pubs.acs.org/doi/10.1021/ja01649a004https://doi.org/10.1021/ja01649a004research-articleACS PublicationsRequest reuse permissionsArticle Views401Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Utilization of Corn Gluten Feed by Nile Tilapia (1995)

Abstract Corn gluten feed, a coproduct from the wet milling of corn, was incorporated in diets containing 32 and 36% protein. A 103-d feeding study with Nile tilapia (Oreochromis niloticus) indicated that 32 and 36% protein diets containing corn gluten feed produced weight gains and feed conversion ratios similar to a control diet of commercial 36% protein catfish feed. Protein efficiency ratios of the 32% protein diets were better than those of the 36% protein diet and the control diet. The differences in weight gain and feed conversion ratio between the 32 and 36% protein diets were not significant. The 32% protein diet with fish meal (6%) had no advantage in weight gain or feed conversion ratio over the 32% protein diet without fish meal.
Immobilization of Monolayers of Fc-binding Receptors on Planar Solid Supports (1999)

We report a technique for the preparation of densely packed monolayers of Fc-binding receptors (recombinant protein A, protein G, and chimeric protein A/G) immobilized on the surface of silicon wafers or quartz. The orientation of protein molecules within organized monolayers and the possible ways this orientation can be manipulated are of great importance for practical applications. The organized protein monolayers can be utilized as recognition layers for minimally invasive optical immunosensors. Here we describe the use of immobilized Fc-binding receptors to orient the antibody molecules on the surface with their Fab fragment directed outward to the film support. The specific adsorption of antibodies on the surface provides enhanced properties of the film, such as a high degree of IgG molecular orientation and adjustable molecular density of the IgG monolayer.

Our approach was based on a combination of high temperature silanization of the quartz surface and the Langmuir-Blodgett technique. The protein monolayers were produced by Langmuir-Blodgett assembly, a process in which protein molecules are mechanically forced together by compression on the water-air interface. The compressed protein film was then transferred onto the activated …
Superfast liner implosion physics study and development of X-ray facility based on 900 MJ inductive store (2003)

The fast liner implosion program on the 8-module pulsed power facility "Angara5-1" with output power 9 TW, electrical pulse rise time 90 ns and load peak current 4 MA is under development at TRINITI. The main program objective is directed on high intensity soft X-ray source creation for ICF and basic research. Double liner concept has been suggested as a promising way to provide a dynamic hohlraum for pellet irradiation. As a more achievable way to get pulsed power generator with multi tens megampere current a joint team of scientists from TRINITI, D.V. Efremov, Tomsk, Ekaterinburg and another laboratory have developed the concept of Super Angara facility, tentatively named as Baikal. The design is based on using of the tokamak T-14 power supply facility and infrastructure that are existing in TRINITI.
Replacing the spotlight with a Kalman filter: A prediction error model of multiple object tracking (2014)

Does multiple object tracking (MOT) rely on the predicted motion of an object? We addressed this using a continuous tracking paradigm (Exp 1), in which observers tracked 4 of 10 dots moving at 8°/s for 8s. On each 16.6ms frame, all dots had a .025 probability of turning 0°, 15°, 30°, 45°, 60°, 75°, or 90° in either direction (held constant within a trial, but varied across trials). Performance was best in the 0° condition, and declined as turn angle increased (p =.003). We used Kalman filters to model this effect of motion predictability on tracking by estimating the distance between a target's predicted and actual location, creating a "prediction field". Assuming an independent filter attached to each target, and that the probability of a swapping error increases with the number of times a distractor passes into a target's prediction field, we computed a swap potential for each target and averaged these to obtain a mean swap potential. We found that swap potential correlated highly with performance in Exp 1 (r = -.89, p <.01). We then tested our model on two other factors known to affect MOT performance: item speed (Exp 2), and trial duration (Exp 3). In Exp 2, speed ranged from 5-11°/s (p <.001). In Exp 3, speed was held constant at 8°/s, and duration ranged from 4-12s (p <.001). Both Exps 2 and 3 used a turn angle of 0°. We again found a high correlation between performance and swap potential (Exp 2: r = -.96, p =.001; Exp 3: r = -.95, p =.001). Taken together, these results not only suggest that observers are sensitive to the predictability of an item's motion, but also that a simple model of swapping potential built from prediction errors can estimate relative performance across a number of tracking tasks. Meeting abstract presented at VSS 2014
Liposomal drug delivery to the eye and lungs: a preliminary electron microscopy study (1993)

Colloidal gold was used as an electron-dense marker for multilamellar vesicles to study the mechanism of liposome drug delivery to the eye and lung. A gold labelled multilamellar vesicle could be seen in the conjunctiva but there was no evidence of vesicles adsorbed to the epithelial surface of cornea or conjunctiva. In the lung, a free gold particle was isolated in type 1 epithelial cells and many vesicular structures were observed in the alveolar spaces which were not gold labelled. Experiments performed so far indicate that adsorption and not endocytosis was the major mechanism of uptake of drug or marker for multilamellar vesicles except for conjunctiva.
<title>Reversible integer-to-integer transforms and symmetric extension of even-length filter banks</title> (2003)

The recent JPEG2000 image coding standard includes a lossless coding mode based on reversible integer to integer filter banks, which are constructed by inserting rounding operations into the filter bank lifting factorisation. The baseline (Part 1) of the JPEG2000 standard supports a single reversible filter bank, the finite length input to which is symmetrically extended to avoid difficulties at the boundaries. While designing support for arbitrary filter banks for Part 2 of the standard, we discovered that reversibility is not always possible for even length integer to integer filter banks combined with symmetric pre-extension.
Characterisation of Yb-Tm co-doped air-clad fibers for 2 &#x00B5;m laser applications (2010)

We have fabricated three Tm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> and Yb <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> co-doped air-clad fibres with varying Yb:Tm ratio. We have studied the 2 μm lasing in a simple cavity and have shown improved performance for increased Yb:Tm ratio.
TEMPO‐Substituted Poly(ethylene sulfide) for Solid‐State Electro‐Chemical Charge Storage (2021)

A poly(ethylene sulfide) backbone is introduced as the main chain of a radical polymer. Anionic ring-opening polymerization of an episulfide monomer substituted with 2,2,6,6tetramethylpiperidin1oxyl (TEMPO), a robust nitroxide radical, yields the corresponding polythioether. Compared to the traditional poly(ethylene oxide) backbone, the new polymer shows a lower glass transition temperature (-10 °C), and about threefold higher solid-state ionic conductivity. The polythioether is also shown to improve the charge/discharge properties of a cathode in solid-state lithium-ion batteries.
Sequential laparoscopy and laparotomy combined with bone marrow biopsy in staging Hodgkin's disease. (1976)

In a series of 121 unselected, previously untreated patients with Hodgkin's disease staging laparoscopy combined with needle bone marrow biopsy detected the presence of extranodal disease in the liver or marrow or both in 9% of the patients. A spleen biopsy yielded positive findings in 13%. Subsequent laparotomy with open marrow biopsy performed in 110 patients with negative liver and marrow findings from the first combined procedure revealed the presence of extranodal hepatic lymphoma in two additional spleens. Surgical marrow biopsy was always interpretey. Although devoid of major complications, biopsy of the spleen is not recommended as a routine procedure in staging laparoscopy. This prospective sequential study confirms that laparoscopy plus needle marrow biopsy is a useful, rapid, safe, and economic procedure to establish stage IV disease in the large majority of patients with nodal involvement. Considering the recent more extensive use of chemotherapy for intermediate stages of Hodgkin's disease, our findings suggest that laparotomy with splenectomy needs a critical re-evaluation as a routine staging procedure for patients with no overt extranodal lymphoma.
An Interaction Study Between the New Antiepileptic and CNS Drug Carisbamate (RWJ‐333369) and Lamotrigine and Valproic Acid (2007)

There were no clinically significant interactions between carisbamate and VPA or LTG. Concomitant administration of carisbamate with VPA or LTG was generally safe and well tolerated.
Synthesis and Application of a Chiral Diborate (2011)

A chiral diborate with different counterions is reported whose structure was unambiguously confirmed by X-ray analysis. This chiral dianion was used in the resolution of trans-1,2-diamines and also as a chiral shift reagent for NMR analysis of triphenylphosphonium salts.
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry (2018)

Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the <i>RPGR</i> gene and its interacting partners, <i>RPGRIP1</i> and <i>RPGRIP1L</i>, cause ciliopathies, but the function of their proteins remains unclear. Here we show that knockdown (KD) of <i>RPGR, RPGRIP1</i> or <i>RPGRIP1L</i> in hTERT-RPE1 cells results in abnormal actin cytoskeleton organization. The actin cytoskeleton rearrangement is regulated by the small GTPase RhoA via the planar cell polarity (PCP) pathway. RhoA activity was upregulated in the absence of RPGR, RPGRIP1 or RPGRIP1L proteins. In <i>RPGR, RPGRIP1</i> or <i>RPGRIP1L</i> KD cells, we observed increased levels of DVl2 and DVl3 proteins, the core components of the PCP pathway, due to impaired proteasomal activity. <i>RPGR, RPGRIP1</i> or <i>RPGRIP1L</i> KD cells treated with thapsigargin (TG), an inhibitor of sarcoendoplasmic reticulum Ca<sup>2+</sup>- ATPases, showed impaired store-operated Ca<sup>2+</sup> entry (SOCE), which is mediated by STIM1 and Orai1 proteins. STIM1 was not localized to the ER-PM junction upon ER store depletion in <i>RPGR, RPGRIP1</i> or <i>RPGRIP1L</i> KD cells. Our results demonstrate that the RPGR protein complex is required for regulating proteasomal activity and for modulating SOCE, which may contribute to the ciliopathy phenotype.
Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms (1999)

Cholinergic hyperexcitation can be induced by both acute psychological stress and exposure to acetylcholinesterase inhibitors. Both factors are known risk factors for delayed neurodeterioration processes such as Alzheimer's disease and Parkinson's disease. Recent publications on the involvement of cholinergic pathways in these and other neurodeterioration syndromes are reviewed.
Thermophysical Properties of Monoporous Sintered Copper (2005)

Thermophysical properties of monodispersed-sintered copper are measured. An apparatus to measure effective thermal conductivity of dry and wet samples is built. It is calibrated using bulk samples with known thermal conductivity. Permeability is measured based on flow resistance though the porous samples. Velocity at different pressure drops is measured and the permeability calculated using Darcy’s law. The experiment is performed using water and silicone oil as working liquids. The error of the measurement is less then five percent. Capillary pressure for all samples is measured based on amount of liquid that is held by the porous sample. The Young-Laplace relationship is used to relate capillary pressure to effective pore radius. Porosity of the samples is calculated by measuring the dimension of samples and weighing the amount of liquid in fully saturated samples. Thermal conductivity and capillary pressure are found to decrease as powder diameter increases; permeability and porosity increases with powder diameter.
Combining Separation Processes to Resolve Racemic Mixtures (2013)

Enantiomers are pairwise occurring molecules, which are non-superimposable mirror images one of the other. Due to homochirality of life, there is a large interest and need to produce pure enantiomers in the pharmaceutical, fine chemical, food and agrochemical industries. Their provision is a challenging task since standard non-selective chemical synthesis always leads to racemic (50:50) mixtures and there is tremendous interest in the mentioned industries to develop innovative methods allowing for a faster access to pure enantiomers. The simplest but rare case that the chiral compound crystallizes as a conglomerate, it is most attractive to apply directly preferential crystallization. However, more frequently racemic compounds are formed during crystallization from racemic feed mixtures. In these cases an initial enrichment is required prior to crystallizing a pure anantiomer. This enrichment might be provided by a partially selective synthesis or can be generated by an initial alternative separation process. The presentation will summarize results of several case studies devoted to combine membrane separation and preparative chromatography with subsequent enantioselective crystallization. The specific degree of enrichment required for successful crystallization was specified always based on preliminary measurements of ternary phase diagrams.
Kinetics of denaturation of DNA (1969)

Abstract The kinetics of denaturation of DNA have been studied by relaxation techniques. Examination of the terminal relaxation times for a variety of DNA's under a variety of conditions has shown that DNA denaturation is principally a hydrodynamically limited process. Measurements within the helix–coil transition have demonstrated that the experimentally measured terminal relaxation times are a function of the following: (1) position in the helix–coil transition; (2) ionic strength of the solvent; (3) solvent viscosity; (4) DNA concentration; (5) molecular weight; (6) number and position of single‐strand breaks. The dependence of the terminal relaxation time on the above mentioned factors can be attributed to hydrodynamic effects. Thus a hydrodynamic model for DNA unwinding is required. The model which best fits the data involves the assumption of a rotational frictional coefficient independent of molecular weight. This assumption is suggested by the fact that the relaxation time is proportional to the first power of the molecular weight.
DEVELOPMENT OF AN EFFECTIVE ENERGY MANAGEMENT SYSTEM IN POWER PLANTS OF PAKISTAN (2016)

In many regions of the world the management of energy conserves is a challenging task. Numerous factors inclusive of economic, environmental and political are having substantial effects on energy management practices, leading to a variety of reservations in appropriate decision making. Energy Management System (EnMS) provides a standardized roadmap for organization efficiency, effectiveness and profitability. By using the EnMS techniques, energy losses could be reduced, and there is substantial saving of fuel which could be used for further power generation. ISO50001:2011 is the standard that deals with EnMS. The objective of the current research work is to pinpoint the optimal approaches in the development of Energy Management Systems (EnMS) of a Combined Cycle Power Plant (CCPP). The CCPP was analyzed for a period of six months for the development of EnMS. Results showed that there were saving of 8.13 × 10 6 BTUs of energy which means a saving of Rs.480000 per day, which will keep on increasing as a result of the implementation of the developed EnMS, hence improving the overall efficiency of the system. The results obtained from the current research could be utilized as a guide for the further design and operation of the industrial energy management system.