gebhart/patrepeval huggingface dataset:
Computer Controlled On-line Calibrations in Solids Flow with a Slot Flow Meter (1996)

Computer controlled on-line calibration of a slot flow meter has allowed alumina mass flow rates and hence the mass of alumina passed through the meter, between calibrations, to be predicted within 3 wt%, for feed rates up to II g/s. Regular drainage calibrations which correct for material variability and meter blockage require no prior knowledge of equations describing flow phenomena.
Standardized Intraabdominal Abscess Formation with Generalized Sepsis: Pathophysiology in the Rat (1985)

Gelatine capsules containing Escherichia coli and Bacteroides fragilis in a standardized mixture with rat colonic content and barium sulfate were implanted intraabdominally into rats. Capsules of 0.75 g gave approximately 50% mortality whereas 0.35 and 1.10 g caused no or 100% mortality, respectively. In subsequent experiments, using the 0.75 g capsule, all animals became ill with signs of tachypnea, piloerection, low physical activity and hypersecretion of saliva 6-8 h after the implantation. The animals reduced their water and food intake substantially and the body weight decreased. A significant reduction in blood pressure, glucose and leukocyte and platelet counts was found 12 h after challenge. Blood cultures obtained at 12, 24, 48 and 60 h all grew E. coli but none B. fragilis. Succumbed animals revealed diffuse peritonitis with growth of E. coli and B. fragilis at autopsy, whereas surviving animals showed abscess formation at investigation on day 8 after challenge. It was concluded that the model closely resembled intraabdominal abscess formation with sepsis in man.
N ε-Lysine Acetylation Control Conserved in All Three Life Domains (2010)

Working with microbes provides opportunities to better understand fundamental cellular processes, including some that, although discovered in eukaryotes, have their origins in Bacteria or Archaea. One such example, reversible N
e-lysine (N
e-Lys) acetylation of proteins, appears crucial for all organisms. With that universality in mind, the relative simplicity of bacteria and archaea could prove critical for advancing our understanding of how this posttranslational modification system influences cell survival.
Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion (2002)

We have hypothesized that most cases of aphasia or hemispatial neglect due to acute, subcortical infarct can be accounted for by concurrent cortical hypoperfusion. To test this hypothesis, we demonstrate: (i) that pure subcortical infarctions are associated with cortical hypoperfusion in subjects with aphasia/neglect; (ii) that reversal of cortical hypoperfusion is associated with resolution of the aphasia; and (iii) that aphasia/neglect strongly predicts cortical ischaemia and/or hypoperfusion. We prospectively evaluated a consecutive series of 115 patients who presented within 24 h of onset or progression of stroke symptoms, with MRI sequences including diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI), and detailed testing for aphasia or hemispatial neglect. The association between aphasia or neglect and cortical infarct (or dense ischaemia) on DWI and cortical hypoperfusion indicated by PWI, was evaluated with chi-squared analyses. Fisher exact tests were used for analyses with small samples. Cases of DWI lesion restricted to subcortical white matter and/or grey matter structures (n = 44) were examined for the presence of aphasia or neglect, and for the presence of cortical hypoperfusion. In addition, subjects who received intervention to restore perfusion were evaluated with DWI, PWI, and cognitive tests before and after intervention. Finally, the positive predictive value of the cognitive deficits for identifying cortical abnormalities on DWI and PWI were calculated from all patients. Of the subjects with only subcortical lesions on DWI in this study (n = 44), all those who had aphasia or neglect showed concurrent cortical hypoperfusion. Among the patients who received intervention that successfully restored cortical perfusion, 100% (six out of six) showed immediate resolution of aphasia. In the 115 patients, aphasia and neglect were much more strongly associated with cortical hypoperfusion (chi(2) = 57.3 for aphasia; chi(2) = 28.7 for neglect; d.f. = 1; P < 0.000001 for each), than with cortical infarct/ischaemia on DWI (chi(2) = 8.5 for aphasia; chi(2) = 9.7 for neglect; d.f. = 1; P < 0.005 for each). Aphasia showed a much higher positive predictive value for cortical abnormality on PWI (95%) than on DWI (62%), as did neglect (100% positive predictive value for PWI versus 74% for DWI). From these data we conclude that aphasia and neglect due to acute subcortical stroke can be largely explained by cortical hypoperfusion.
Modeling of emitter capacitance (1969)

A modified emitter transition layer capacitance representation is given which is free of singularities and allows modeling of the capacitance for voltages up to the "built-in" voltage.
The Method of Execution (1953)

<h3>Introduction</h3> Viral gastroenteritis with dehydration is one of the most frequent reasons for visits to pediatric Emergency Departments (ED). Worldwide dehydration is among the top causes of mortality in preschool children. Parental intervention at home can make a difference in the course of a child’s illness. <h3>Objectives</h3> This project is part of a program of research to design an educational tool for parents of preschoolers with gastroenteritis. The primary objective of this phase was to validate an interview guide. From initial data, the researchers explored parental motivations for bringing their children to the ED. <h3>Methods</h3> Ten families were recruited from the pediatric ED. Included were families of children under 4 with vomiting, diarrhea and dehydration. Telephone interviews were recorded and transcribed. The interview guide was edited for face and content validity. To ensure rigor, thematic analysis was done by all investigators. <h3>Results</h3> The interview guide was validated. Probes were added, and likert scale questions were standardized. Thematic analysis focused on parents’ decision to take their child to the ED. Making this decision is complex, involving community-level, family-level, and child factors. Access to medical care, including perceived urgency, travel time and mode of transport, impacts parents’ decision. <h3>Conclusions</h3> A model outlines the most important factors our sample of parents report when deciding to take their ill child to the ED. Making the decision about an ill child is more complex than when individuals decide for themselves. The interview guide developed will facilitate collection of further information to test our model.
ChemInform Abstract: Synthesis and Psychotropic Properties of Arylamides of 3‐Oxo‐1,2,3,5‐tetrahydropyrido[1,2‐a]benzimidazole‐4‐carboxylic Acid. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Direct Imaging of Extra-solar Planets (1997)

Direct imaging of extra-solar planets may be possible with the new generation of large ground-based telescopes equipped with state- of- the-art adaptive optics (AO) systems to compensate for the blurring effect of the Earth`s atmosphere. The first of these systems is scheduled to begin operation in 1998 on the 10 in Keck II telescope. In this paper, general formulas for high-contrast imaging with AO systems are presented and used to calculate the sensitivity of the Keck AO system. The results of these calculations show that the Keck AO system should achieve the sensitivity necessary to detect giant planets around several nearby bright stars.
Design and analysis choices for safety surveillance evaluations need to be tuned to the specifics of the hypothesized drug-outcome association (2016)

One cause of reproducible "error" may be repeated failure to tie design choices closely enough to the research question at hand. Copyright © 2016 John Wiley & Sons, Ltd.
On-Line Particle Size Determination during Latex Production Using Dynamic Light Scattering (1990)

This chapter describes a system for automatic sample acquisition and dilution designed to interface with a particle-sizing instrument based on dynamic light scattering. Results are shown of the successful use of this technology to monitor on-line particle growth during the emulsion polymerization of vinyl acetate in a pilot-plant reactor. Automatic sampling every 10-15 min is achievable; therefore this system is a powerful new tool for on-line monitoring and control of latex production.
Transcriptional mechanisms of acute lung injury (2001)

Acute lung injury occurs as a result of a cascade of cellular events initiated by either infectious or noninfectious inflammatory stimuli. An elevated level of proinflammatory mediators combined with a decreased expression of anti-inflammatory molecules is a critical component of lung inflammation. Expression of proinflammatory genes is regulated by transcriptional mechanisms. Nuclear factor-kappa B (NF-kappa B) is one critical transcription factor required for maximal expression of many cytokines involved in the pathogenesis of acute lung injury. Activation and regulation of NF-kappa B are tightly controlled by a complicated signaling cascade. In acute lung injury caused by infection of bacteria, Toll-like receptors play a central role in initiating the innate immune system and activating NF-kappa B. Anti-inflammatory cytokines such as interleukin-10 and interleukin-13 have been shown to suppress inflammatory processes through inhibiting NF-kappa B activation. NF-kappa B can interact with other transcription factors, and these interactions thereby lead to greater transcriptional selectivity. Modification of transcription is likely to be a logical therapeutic target for acute lung injury.
ROAD POWERED ELECTRIC VEHICLE TECHNOLOGY STUDY (SAINTS ROAD PROJECT). VOLUME I: RESEARCH SUMMARY (1995)

Volume I of this report presents summary results of a 10-month evaluation of E-TRAN Road Powered Electric Vehicle (RPEV) technology to determine operational safety and system durability/reliability; technology effectiveness; snow and ice removal requirements; and cost effectiveness. Through a series of theoretical and laboratory tests, this evaluation concludes that the E-TRAN RPEV concept remains sound in theory, but as tested under the current design, the system does not yet provide a safe and reliable transportation power alternative. The study addressed some findings of a previous report (No. MN/RC-93/03). However, the system design is still an immature technology under development, and must address significant safety and practical problems. Especially, the system must be made more robust and resistant to stresses and conditions found in a northern public roadway environment. A laboratory test indicated a 46% reduction in energy consumption compared to gasoline power. The E-TRAN RPEV concept holds further promise as a possible solution to the limited range and energy efficiency of battery-powered vehicles. The report identifies several areas for further study and development and also provides recommendations to focus on future development of identified safety and technical design areas. Volume II includes detailed test reports for tests performed, as well as estimates of capital and operating cost comparisons.
Survival of patients with metastatic leiomyosarcoma: the MD Anderson Clinical Center for targeted therapy experience (2016)

Advanced stage leiomyosarcoma (LMS) is incurable with current systemic antitumor therapies. Therefore, there is clinical interest in exploring novel therapeutic regimens to treat LMS. We reviewed the medical records of 75 consecutive patients with histologically confirmed metastatic LMS, who had been referred to the Clinical Center for Targeted Therapy at MD Anderson Cancer Center. To lay the foundation for potential phase I trials for the treatment of advanced LMS, we analyzed tumor response and survival outcome data. The frequent hotspot gene aberrations that we observed were the TP53 mutation (65%) and RB1 loss/mutation (45%) detected by Sequenom or next-generation sequencing. Among patients treated with gene aberration-related phase I trial therapy, the median progression-free survival was 5.8 months and the median overall survival was 15.9 months, significantly better than in patients without therapy (1.9 months, P = 0.001; and 8.7 months, P = 0.013, respectively). Independent risk factors that predicted shorter overall survival included hemoglobin <10 g/dL, body mass index <30 kg/m<sup>2</sup> , serum albumin <3.5 g/dL, and neutrophil above upper limit of normal. The median survivals were 19.9, 7.6, and 0.9 months for patients with 0, 1 or 2, and ≥3 of the above risk factors, respectively (P < 0.001). A prognostic scoring system that included four independent risk factors might predict survival in patients with metastatic LMS who were treated in a phase I trial. Gene aberration-related therapies led to significantly better clinical benefits, supporting that further exploration with novel mechanism-driven therapeutic regimens is warranted.
Adjustment of Prism Turnstile Resonators Latched by Wire Loops (2018)

This chapter investigates the operation of a prism resonator using a single irregular hexagonal wire loop in terms of the ratio of the inner and one typical rib of the outer tri-toroidal geometry. The results obtained are expressed in terms of a shape factor defined by the ratio of the inner core of the tri-toroidal resonator and one typical outer rib. The prism resonator under consideration consists of a half-wave long gyromagnetic waveguide with open flat faces separated by dielectric spacers from top and bottom triangular platforms. The most important quantity entering into the description of either a fixed field or latched junction circulator is the quality factor of its complex gyrator circuit. This quantity is solely determined by the difference between the opening of the counterrotating frequencies of the resonator. The physical variables of the in-phase eigen-network do not explicitly appear in the description of the complex gyrator circuit, provided it is separately idealized.
Predicting survival in patients with acute decompensated heart failure complicated by cardiogenic shock (2021)

A simple score including age, lactates and creatinine on admission could be considered to predict short-term mortality in CS-ADHF patients in order to drive towards a treatment intensification.
Identification, cloning and lactonase activity of recombinant protein of N-acyl homoserine lactonase (AiiA) from Bacillus thuringiensis 147-115-16 strain. (2014)

En el Repositorio Universidad de Santander están depositados materiales en formato digital fruto de la producción científica o académica, de esta manera permite almacenar, difundir y preservar información de vital importancia.
System Reliability: Concepts and Applications (1992)

Part 1 Deterministic reliability: Arrhenius' model failure mechanisms screening. Part 2 Statistical reliability: nomenclature operational reliability quantities. Part 3 Statistical failure of components: failure distributions - negative-exponential, normal, lognormal, Weibull and gamma distribution life distribution measurements. Part 4 Reliability models: catastrophic failure model stress-strength model Markov model. Part 5 Non-maintained systems: series systems redundancy parallel systems m-out-of-n systems majority voting systems mixed systems optimization analysis methods. Part 6 Maintained systems: systems with preventive maintenance - scheduled and condition-based systems with corrective maintenance - with and without redundancy, shared-repair facilities, inhomogenous systems maintenance aspects. Part 7 Evaluation methods: causal evaluation - FMEC analysis anti-causal evaluation - fault-tree analysis risk and safety. Part 8 Reliability of computer software: writing reliable software reliability testing failure model. Solutions to problems. Appendices: applied Laplace transforms the Central Limit theorem most commonly used symbols.
Renewable Energy Alternatives for Remote Communities in Northern Ontario, Canada (2013)

The paper investigates renewable energy alternatives to reduce diesel fuel dependency on electricity generation in Ontario's remote northern communities; currently, these communities use diesel fuel as the sole energy source to produce electricity. The current operation is complex, involving several stakeholders, high operating costs, and a considerable CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> footprint. Several of these communities have electric load restrictions that limit further building construction and economic growth. This preliminary work discusses the barriers for renewable energy (RE) projects in northern Ontario communities by analyzing the current economic structure, the high capital costs, the available natural resources, and the installation and operation complexity. Also, a detailed analysis of six scenarios is presented; three scenarios consider a solar and/or wind-diesel system with a low RE penetration of 7% without any excess energy, whereas other three scenarios increase the RE penetration to 18%, requiring a dump load, an additional small diesel engine, or a battery storage system. The proposed systems reduce fuel consumption, operating costs and CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> emissions, considering the investment, operation and maintenance costs and constraints in remote regions.
A Tris(μ-hydroxy)tricopper(II) Complex as a Model of the Native Intermediate in Laccase and Its Relationship to a Binuclear Analogue (2005)

The reaction of a copper(I) complex with a sterically demanding secondary diamine ligand and O2 yields a tris(mu-hydroxy)tricopper(II) complex. This complex is a structural model of the proposed native intermediate in multicopper oxidases, with interesting structural, magnetic, and solution properties.
Dimeric Chemotactic Peptides Discriminate between Chemotaxis and Superoxide Production of Human Neutrophils1 (1995)

A series of dimeric fMLPs were synthesized by cross-linking with hydrophilic linkers, mono-, di-, tri-, and tetraethylene glycols. All of the dimers showed higher activities than monomeric fMLP in chemotaxis assays for human neutrophils. The magnitude of the activity enhancement was dependent on the linker length. On the other hand, production of superoxide anion was not as enhanced as chemotaxis. The experimental results indicate that these dimers, especially the triethylene glycol-bridged fMLP dimer, D-fMLP-G3, are selective agonists for chemotaxis. In order to distinguish between biological activities and intracellular signaling, rapid mobilization of the intracellular calcium was also measured. D-fMLP-G3 strongly enhanced the calcium mobilization. These results suggest that chemotaxis was correlated with the increase of the intracellular calcium concentration, whereas NADPH oxidase was not activated to generate superoxide by this elevation of cytoplasmic calcium caused by the dimeric ligand, D-fMLP-G3. The dimeric fMLPs might act as useful ligands for studying the intracellular signaling mechanisms of human neutrophils.
Comparison of the Activities of Zanamivir, Oseltamivir, and RWJ-270201 against Clinical Isolates of Influenza Virus and Neuraminidase Inhibitor-Resistant Variants (2001)

RWJ-270201 is a novel cyclopentane inhibitor of influenza A and B virus neuraminidases (NAs). We compared the ability of RWJ-270201 to inhibit NA activity of clinical influenza isolates and viruses with defined resistance mutations with that of zanamivir and oseltamivir carboxylate. In NA inhibition assays with influenza A viruses, the median 50% inhibitory concentration (IC(50)) of RWJ-270201 (approximately 0.34 nM) was comparable to that of oseltamivir carboxylate (0.45 nM) but lower than that of zanamivir (0.95 nM). For influenza B virus isolates, the IC(50) of RWJ-270201 (1.36 nM) was comparable to that of zanamivir (2.7 nM) and less than that of oseltamivir carboxylate (8.5 nM). A zanamivir-resistant variant bearing a Glu119-to-Gly (Glu119-->Gly) or Glu119-->Ala substitution in an NA (N2) remained susceptible to RWJ-270201 and oseltamivir carboxylate. However, a zanamivir-selected variant with an Arg292-->Lys substitution in an NA (N2) showed a moderate level of resistance to RWJ-270201 (IC(50) = 30 nM) and zanamivir (IC(50) = 20 nM) and a high level of resistance to oseltamivir carboxylate (IC(50) > 3,000 nM). The zanamivir-resistant influenza B virus variant bearing an Arg152-->Lys substitution was resistant to each NA inhibitor (IC(50) = 100 to 750 nM). The oseltamivir-selected variant (N1) with the His274-->Tyr substitution exhibited resistance to oseltamivir carboxylate (IC(50) = 400 nM) and to RWJ-270201 (IC(50) = 40 nM) but retained full susceptibility to zanamivir (IC(50) = 1.5 nM). Thus, drug-resistant variants with substitutions in framework residues 119 or 274 can retain susceptibility to other NA inhibitors, whereas replacement of functional residue 152 or 292 leads to variable levels of cross-resistance. We conclude that RWJ-270201 is a potent inhibitor of NAs of wild-type and some zanamivir-resistant or oseltamivir-resistant influenza A and B virus variants.
ELVIS (2013)

In this article, we propose ELVIS, a security-oriented log visualization tool that allows security experts to visually explore numerous types of log files through relevant representations. When a log file is loaded into ELVIS, a summary view is displayed. This view is the starting point for exploring the log. The analyst can then choose to explore certain fields or sets of fields from the dataset. To that end, ELVIS selects relevant representations according to the fields chosen by the analyst for display.
Two-Dimensional Hexagonal Lattice Photonic Crystal Band-Edge Laser Patterned by Nanosphere Lithography (2012)

We report a two-dimensional (2D) photonic crystal (PC) band-edge laser that was fabricated in an InGaAsP multiple-quantum-well structure by nanosphere lithography (NSL). NSL utilizes a nanosphere monolayer self-assembled into a hexagonal lattice as a mask for fabricating a 2D PC composed of circular air holes. A clear laser emission at around 1550 nm was observed under pulsed optical pumping. From the calculated band structure and polarization dependence measurement, the lasing is confirmed to occur at the M1-point band-edge mode. These results demonstrate that NSL, which does not require any sophisticated nanolithographic equipment, is a simple yet precise method for PC research and application.