gebhart/patrepeval huggingface dataset:
Synthesis and Properties of <i>g</i><i>em</i>-(Difluorocyclopropyl)amine Derivatives of Bicyclo[<i>n</i>.1.0]alkanes (2004)

[reaction: see text] Generation of difluorocarbene(carbenoid) in the presence of enamines derived from cyclic ketones results in overall insertion of CF2 to produce bicyclic difluorocyclopropylamines. These adducts are very weakly basic, and their thermal stabilities vary markedly with their structures.
Zur Antitumorwirkung o‐substituierter [1,2‐Bis(4‐hydroxyphenyl)‐ethylendiamin]dichloroplatin(II)‐Komplexe und ihrer Methylether (1988)

Abstract Die Synthese der in o‐Stellung CH 3 ‐, CF 3 ‐, F‐, Cl‐, Br‐, I‐ und OCH 3 ‐substituierten [1,2‐Bis(4‐methoxyphenyl)ethylendiamin]dichloroplatin(II)‐Komplexe 1a‐PtCl 2 bis 7a‐PtCl 2 wird beschrieben. Ihre Wirkung an der menschlichen, hormonunabhängigen MDA‐MB‐231 Brustkrebszellinie und an der lymphocytischen Leukämie P 388 der Maus wird mit der analog o‐substituierter [1,2‐Bis(4‐hydroxyphenyl)ethylendiamin]dichloroplatin(II)‐Komplexe ( 1b‐PtCl 2 bis 7b‐PtCl 2 ) verglichen. Die 4‐OH substituierten Platinkomplexe ( 1b‐PtCl 2 bis 7b‐PtCl 2 ) hemmen das Tumor‐wachstum beider Tumormodelle stärker als die entsprechenden 4‐OCH 3 ‐substituierten Platinkomplexe 1a‐PtCl 2 bis 7a‐PtCl 2 , die Effekte sind jedoch im Vergleich zum Cisplatin schwächer ausgeprägt.
.DELTA.-Indomycinone: A New Member of Pluramycin Class of Antibiotics Isolated from Marine Streptomyces sp. (1997)

In a continuation of our investigation for bioactive secondary metabolites from marine microorganisms1}, we have isolated a new pluramycin type metabolite 5indomycinone (2), along with the known antibiotic /?indomycinone (1)2). Both compounds were extracted from the culture broth of a Streptomyces strain (B 8300), obtained from the collection of marine actinomycetes at Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany. Pluramycin metabolites containing the 4tf-anthra[l ,2-Z>]pyran-4,7, 1 2-trione nucleus to which amino sugars typically are attached at C-8 and C-10 positions, were most commonly isolated from terrestrial Streptomyces sp. The pluramycin analogues which lack any carbohydrate substitution are the pluramycinones such as indomycinones3). The pluramycins are a group of highly structurally evolved DNA reactive agents and found to have antimicrobial and
Reaction dynamics of O(1D)+H2, D2, and HD: Direct evidence for the elusive abstraction pathway and the estimation of its branching (1997)

The dependencies of the integral cross sections for the title reactions on collision energies were determined from 0.6 kcal/mol to nearly 6 kcal/mol. The result provides, for the first time, direct and unambiguous experimental evidence for the existence of an abstraction pathway, in addition to the widely accepted inserted one. A reaction barrier of about 1.8 kcal/mol was found for this elusive abstraction channel. The branching of these two microscopic pathways was estimated. An intriguing H/D isotope effect was revealed, which called for further studies.
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines (2005)

Recent studies have led to considerable advancement in our understanding of the molecular mechanisms that underlie the relentless cell growth and invasiveness of human gliomas. Partial understanding of these mechanisms has (1) improved the classification for gliomas, by identifying prognostic subgroups, and (2) pointed to novel potential therapeutic targets. Some classes of ion channels have turned out to be involved in the pathogenesis and malignancy of gliomas. We studied the expression and properties of K(+) channels in primary cultures obtained from surgical specimens: human ether a gò-gò related (hERG)1 voltage-dependent K(+) channels, which have been found to be overexpressed in various human cancers, and human ether a gò-gò-like 2 channels, that share many of hERG1's biophysical features. The expression pattern of these two channels was compared to that of the classical inward rectifying K(+) channels, IRK, that are widely expressed in astrocytic cells and classically considered a marker of astrocytic differentiation. In our study, hERG1 was found to be specifically overexpressed in high-grade astrocytomas, that is, glioblastoma multiforme (GBM). In addition, we present evidence that, in GBM cell lines, hERG1 channel activity actively contributes to malignancy by promoting vascular endothelial growth factor secretion, thus stimulating the neoangiogenesis typical of high-grade gliomas. Our data provide important confirmation for studies proposing the hERG1 channel as a molecular marker of tumour progression and a possible target for novel anticancer therapies.
Corrigendum: A Bioreducible Polymer for Efficient Delivery of Fas‐Silencing siRNA into Stem Cell Spheroids and Enhanced Therapeutic Angiogenesis (2013)

The authors of this Communication unintentionally provided the incorrect recommended name “9β-presilphiperfolan-1α-ol” for the natural product isolated by König and Leitão. The correct name should instead be “9β-presilphiperfolan-1β-ol” to reflect the syn orientation of the hydroxy group relative to the C9-methyl group of the natural product. This error appears in the table-of-contents graphic, a portion of the article text, and a portion of the Supporting Information.
Filamentation of ultrashort pulse laser beams resulting from their propagation over long distances in air (1999)

The propagation of high-power short-pulse laser beams over considerable distances in air is studied both experimentally and via numerical simulations. Filaments are formed after 5–10 m and their propagation over distances in excess of 200 m is reported for the first time. The lateral dimensions of the filaments are found to range from about 100 μm to a few millimeters in diameter. The early values of plasma electron density have been inferred to be a few times 1016 cm−3 using longitudinal spectral interferometry. For 500 fs pulses and a wavelength of 1053 nm, the energy in the filament can be quite high initially (∼8 mJ) and is found to stabilize at about 1.5–2 mJ, after about 35 m. A simple model based on the nonlinear Schrödinger equation coupled to a multiphoton ionization law appears to describe several experimental results quite well.
Solute-solute-solvent interactions studied through the Kirkwood-Buff theory. 3. Effect of the pressure on Gij for some aqueous and nonaqueous mixtures (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolute-solute-solvent interactions studied through the Kirkwood-Buff theory. 3. Effect of the pressure on Gij for some aqueous and nonaqueous mixturesL. Lepori and E. MatteoliCite this: J. Phys. Chem. 1988, 92, 24, 6997–7001Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/j100335a031https://doi.org/10.1021/j100335a031research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Dispersion along the Mohawk (1955)

As a citizen of Schenectady, New York, and member of the Mohawk Association of Scientists and Engineers, the author was active in a citizens' committee working on dispersion as it related to their own community. Here is the story of their efforts.
The Mild Oxidation of Some Alpha-Difluoro Sulfides to Sulfones with Sodium Perborate (1993)

Abstract Sodium perborate in acetic acid is an effective reagent for the mild oxidation of some electron-deficient sulfides to sulfones.
Microstructures and Spectroscopic Properties of Cryptomelane-type Manganese Dioxide Nanofibers (2008)

Cryptomelane-type manganese dioxide (K-MnO2) nanofibers with typical diameters of 20−60 nm and lengths of 1−6 μm were prepared by reacting KMnO4 with MnSO4 under hydrothermal conditions. Rietveld refinement from synchrotron X-ray powder diffraction data showed that the K-MnO2 nanofibers crystallize in a body-centered tetragonal structure (space group I4/m) with unit cell parameters a = 9.8241(5) Å and c = 2.8523(1) Å and elongate along the <001> direction. The K-MnO2 nanofibers had a mean chemical composition of K0.11(H3O)0.05MnO2. The optical band gap of the K-MnO2 nanofibers was estimated to be 1.32 eV based on the UV−visible absorption. The K-MnO2 nanofibers had four diagnostic infrared absorptions at 722, 593, 524, and 466 cm−l, which represents specific fingerprints of the vibrational features of MnO2 materials containing (2 × 2) + (1 × 1) tunnel structures. The Raman scattering spectrum of the K-MnO2 nanofibers had nine Raman bands with four main contributions at 183, 386, 574, and 634 cm−1 along with five weak ones at 286, 330, 470, 512, and 753 cm−1, which are attributed to the Mn−O lattice vibrations within the MnO6 octahedral frameworks. These intrinsic vibrational features can be conveniently used for online and/or in situ analyses of the K-MnO2 nanofibers during electrochemical and/or ion-exchange reactions.
Highly ordered vertical GaAs nanowire arrays with dry etching and their optical properties (2014)

We report fabrication methods, including metal masks and dry etching, and demonstrate highly ordered vertical gallium arsenide nanowire arrays. The etching process created high aspect ratio, vertical nanowires with insignificant undercutting from the mask, allowing us to vary the diameter from 30 nm to 400 nm with a pitch from 250 nm to 1100 nm and length up to 2.2 μm. A diameter to pitch ratio of ∼68% was achieved. We also measured the reflectance from the nanowire arrays and show experimentally diameter-dependent strong absorption peaks resulting from resonant optical mode excitations within these nanowires. The reflectance curves match very well with simulations. The work done here paves the way towards achieving high efficiency solar cells and tunable photodetectors using III–V nanowires.
The structure and origin of dissolved organic matter studied by UV-vis spectroscopy and fluorescence spectroscopy in lake in arid and semi-arid region (2011)

To develop a proper indicator which could predict water quality and trace pollution sources is critically important for the management of sustainable aquatic ecosystem. In our study, seven water samples collected from Wuliangsuhai Lake in Inner Mongolia were used. UV-visible spectra and synchronous fluorescence spectra were applied to investigate the humification degree and aromatic structure of dissolved organic matter (DOM) extracted from water samples. The results showed that both samples from W1 site and W3 site display lower humification degree and less aromatic structure, where industrial wastewater and domestic sewage, and reclaimed water of farmland irrigation, were accepted respectively. After computing the values of SUVA254, A280, A250/365, A253/203 and A226–400, we reached the conclusion that they have a consistent trend (W4&gt; W6&gt; W5&gt; W2&gt; W7&gt; W1&gt; W3). Fluorescence index (f450/500) was always utilised to interpret the origin of organic matter in a complex aquatic environment system. Values of f450/500 are closer to 1.60, indicating that humic substances derived from terrestrial sources and biological sources. Our study demonstrated that reclaimed water of farmland irrigation, industrial wastewater and domestic sewage will definitely influence the humification degree and amount of the aromatic structure of DOM.
Electron-Rich Arene–Ruthenium Metalla-architectures Incorporating Tetrapyridyl–Tetrathiafulvene Donor Moieties (2014)

A series of arene ruthenium architectures have been prepared from coordination-driven self-assembly using dinuclear p-cymene ruthenium acceptors and π-donating tetratopic tetrapyridyl–tetrathiafulvalene donor ligands. The synthetic strategy, based on a geometric interaction approach, leads to four electroactive metalla-assemblies, 1–4 (one molecular cube and three metallaplates), that were characterized by NMR, ESI-MS, X-ray diffraction, and cyclic voltammetry. Rationalization of their formation discrepancy was completed by DFT calculations supported by structural features of their constituting TTF and Ru-complex components. Metalla-architectures possessing electron-rich cores (3, cis-4, and trans-4) interact strongly with picric acid (PA) to yield cocrystallized products, PA + metalla-assemblies, confirmed by single-crystal X-ray structure analyses.
In vivo wood formation analysis in poplar through cDNA-AFLP technology (2002)

info:eu-repo/semantics/nonPublished
Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in <i>Helicobacter pylori</i> (2002)

Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species. Here we describe development and use of a spectrophotometric assay, based on nitroreduction of NTZ at 412 nm, to identify H. pylori enzymes responsible for its activation and mode of action. Three enzymes that reduce NTZ were identified: two related NADPH nitroreductases, which also mediate susceptibility to metronidazole (MTZ) (RdxA and FrxA), and pyruvate oxidoreductase (POR). Recombinant His-tagged RdxA, FrxA, and POR, overexpressed in nitroreductase-deficient Escherichia coli, each rapidly reduced NTZ, whereas only FrxA and to a lesser extent POR reduced nitrofuran substrates (furazolidone, nitrofurantoin, and nitrofurazone). POR exhibited no MTZ reductase activity either in extracts of H. pylori or following overexpression in E. coli; RdxA exhibited no nitrofuran reductase activity, and FrxA exhibited no MTZ reductase activity. Analysis of mutation to rifampin resistance (Rif(r)) indicated that NTZ was not mutagenic and that nitrofurans were only weakly mutagenic. Alkaline gel DNA electrophoresis indicated that none of these prodrugs caused DNA breakage. In contrast, MTZ caused DNA damage and was strongly mutagenic. We conclude that POR, an essential enzyme, is responsible for most or all of the bactericidal effects of NTZ against H. pylori. While loss-of-function mutations in rdxA and frxA produce a Mtz(r) phenotype, they do not contribute much to the innate susceptibility of H. pylori to NTZ or nitrofurans.
L-Arginine kinase from tobacco hornworm, Manduca sexta (L.). Purification, properties, and interaction with L-canavanine. (1977)

Arginine kinase (adenosine 5'-triphosphate: L-arginine phosphotransferase, EC 2.7.3.3) was purified from the larvae of the tobacco hornworm, Manduca sexta (L). This enzyme catalyzes the production of L-phosphoarginine, which is the principal reserve of high energy phosphate compounds in insect muscle. The enzyme also phosphorylates L-canavanine, a guanidinooxy analogue of arginine which severely disrupts all developmental stages of this insect. Evaluations of certain kinetic and thermodynamic parameters of the reactions with arginine and canavanine suggest that reactions known to be much more sensitive to canavanine, such as protein synthesis or genome expression, rather than phosphagen formation and function account for the pronounced toxicity of canavanine in this insect. Sedimentation equilibrium and electrophoresis on polyacrylamide gels containing sodium dodecyl sulfate indicate that this insect enzyme has a molecular weight of about 40,000. This value is consistent with molecular weights of arginine kinases of non-insect arthropods. Its amino acid composition is also very similar to that of other arthropod arginine kinases. Km values for the enzyme are: L-arginine, 0.5 mM; Mg-ATP, 2.5 mM; L-canavanine, 22 mM; L-phosphoarginine, 0.7 mM; Mg-ADP, 0.45 mM; and L-phosphocanavanine, 27 mM. Turnover numbers (expressed as moles of product per min per mol of enzyme) are: L-arginine, 8,320; L-canavanine, 1,635; L-phosphoarginine, 25,875; and L-phosphocanavanine, 3,040. The apparent equilibrium constants at 37 degrees for phosphagen formation are 0.44 with arginine and 0.1 with canavanine. A procedure for L-phosphocanavanine synthesis is also presented.
Enantioselective Synthesis of the Carbocyclic D‐Ring Subunit of Massadine (2008)

Zum Kern der Sache kommen: Die Strategie für eine effiziente asymmetrische Synthese der D-Ring-Einheit in Massadin (1) umfasst die Anwendung einer kationischen Norbornylumlagerung, eine ozonolytische Spaltung mit bemerkenswerter Endgruppendifferenzierung und eine Carboxyinversion zur Erzeugung des gehinderten sekundären Alkohols.
Optically induced cis-trans isomerisation of (η6-cis-stilbene)Cr(CO)3 (2010)

The femto- and picosecond time resolved spectroscopy of (eta(6)-cis-stilbene)Cr(CO)(3) provides evidence for three optically accessible excited states one leading to cis-trans isomerisation of the coordinated stilbene ligand and another which results in a slow release of CO.
Interactions between Alkanethiols and Gold−Dendrimer Nanocomposites (2001)

Interactions between alkanethiols and gold−dendrimer nanocomposites in ethyl acetate were investigated by adding alkanethiols such as 1-decanethiol and 1,10-decanedithiol into gold−poly(amidoamine)dendrimer nanocomposites. Poly(amidoamine)dendrimers with surface methyl ester groups used were generations of 1.5 and 5.5 (G1.5 and G5.5). The mean particle sizes of gold−dendrimer nanocomposites were about 2.1 nm for G1.5 and 2.4 nm for G5.5. In the case of gold−dendrimer(G1.5) nanocomposites, the addition of 1-decanethiol led to smaller gold particles, while that of 1,10-decanedithiol provided the formation of large, highly regular, spherical clusters with diameters of 40−60 nm. On the other hand, in the case of gold−dendrimer(G5.5) nanocomposites the addition of 1-decanethiol showed a distinct tendency into smaller and larger spheres, whereas that of 1,10-decanedithiol provided irregular spherical clusters with diameters of 30 nm. The mechanisms for morphology changes in the gold−dendrimer nanocomposites by addition of these thiols were discussed.
Sensor Fusion for Industrial Applications Using Transducer Markup Language (2006)

Manufacturing processes would greatly benefit from fusing data from many disparate sensors, but systems today do not fully exploit available sensor data. Disparate sensors could include Coordinate Measurement Machines (CMM), laser surface scanners, micro sensors, cameras, acoustic devices, thermocouples, or other various devices which provide measurement or visual data. Often, sensor data requires separate customized software for each type of sensor system, as opposed to having common tools for use across a wide array of sensor systems. This process of stove-piping requires proprietary software for analysis and display of each sensor type, and inhibits interoperability. There are several challenges to sensor fusion which need to be addressed. First, many sensors providing data are heterogeneous in phenomena detection and operation, providing measurements of different target attributes. This makes the measurements very difficult to fuse directly. Second, these disparate sensors are asynchronous in time. The collection, integration, buffering and transmitting time can each affect the way time is calculated and stored by the sensor. Transducer Markup Language (TML), developed by IRIS Corporation, addresses these challenges. This paper describes TML and addresses examples of industrial applications of TML-enabled transducer networks.
Alteration of Pharmacokinetic Parameters for Pentobarbital by Ischemic Stroke and Reversion to Normal by Dexamethasone Treatment (1980)

The values of the pharmacokinetic parameters for pentobarbital were determined in 18 cats, 12 of which were subjected to acute ischemic stroke by ligation of the left middle cerebral artery (LMCA). All 18 ats received 50 mg/kg sodium pentobarbital during operation. The following three experimental groups were formed: control (sham-operated); ischemic stroke plus administration of 4 mg/kg dexamethasone; and ischemic stroke without dexamethasone administration. Ischemic stroke significantly prolonged the plasma half-life of pentobarbital, but concurrent administration of dexamethasone prevented this effect. Ischemic stroke significantly reduced the plasma clearance of pentobarbital, but dexamethasone prevented this reduction. Ischemic stroke significantly increased the area under the plasma pentobarbital concentration-time curve, but dexamethasone prevented this increase. Ischemic stroke significantly reduced the volume of distribution, but dexamethasone did not prevent this reduction. The alterations of the value of these pharmacokinetic parameters for pentobarbital by ischemic stroke and reversion to normal by dexamethasone treatment are discussed in the light of certain known circulatory changes which occur secondary to ischemic stroke and dexamethasone treatment.
Ground segment architectures for large LEO constellations with feeder links in EHF-bands (2018)

In recent years, several large constellations of LEO satellites have been proposed by different companies as a means to provide global broadband. Even though the first generation of these systems was designed using Ka-band feeder links, the saturation of the Ka-band spectrum, the need for wider bandwidths, and the increasing demand for capacity are driving the industry towards the development of systems with feeder links operating in EHF bands (30-300 GHz). The two main advantages of transitioning towards higher frequency bands are: one, the possibility of using the larger bandwidth allocations available for higher capacities, and two, a reduction in the number of ground sites required to support such capacity. However, there are trade-offs that need to be further explored, since links operating at higher frequencies are impaired by higher atmospheric attenuation, which in turn causes outages and might require of additional ground stations to maintain QoS levels (i.e., given coverage and availability requirements). This paper compares ground segment architectures for constellations using feeder links in Q/V-band against those using E-band. We develop a method to determine the locations of the minimum number of ground stations that maximize the system capacity while achieving desired QoS levels. To that end, first, we use International Telecommunication Union (ITU) models to characterize the atmospheric attenuation in EHF-bands; next, we describe a Monte Carlo simulation method to estimate the statistics of the data-rate achieved when multiple ground stations are within the line-of-sight (LoS) of a given satellite. Finally, we present the results in terms of the number of ground stations required and data-rates achieved, after optimizing over the different ground station locations for both the Q/V-band and E-band scenarios. We then compare these results to the ones obtained using current systems in Ka-band.