gebhart/patrepeval huggingface dataset:
Triggering of Apoptosis is not Sufficient to Induce Human Immunodeficiency Virus Gene Expression (2003)

We examined whether there is any causative link between apoptosis and HIV gene expression elicited in response to ultraviolet light (UV) and ionizing radiation (IR). We found that both UV and IR activate HIV gene expression in human T lymphoblastoid 1G5 (HIVluc) cells, but with different kinetics and magnitudes. Treatment with either type of radiation resulted in increased apoptosis, which correlated closely with HIV gene expression. The involvement of caspases in the IR response was demonstrated by using zVAD-FMK and zDEVD-FMK caspase inhibitors; both apoptosis and HIV gene expression were inhibited to similar extent. Surprisingly, treatment of 1G5 cells with FAS antibody triggered apoptosis but did not increase HIV gene expression. A correlation between increased apoptosis and gene expression was also demonstrated in human carcinoma HIVcat/A549 cells with UV whereas IR triggered apoptosis but did not activate HIV gene expression. Most significantly, UV activation of HIV gene expression, and NF-kappa-B and p38 MAP kinase, both important for efficient HIV gene expression, were not affected by treatment with the zVAD-FMK and zDEVD-FMK inhibitors. Treatment of HIVcat/A549 cells with staurosporine or scrape-loading of cells with cytochrome c resulted in apoptosis but no increase in HIV gene expression. Altogether, a direct correlation exists between apoptosis and HIV gene expression in T-cells in response to both UV and IR but this is not the case in carcinoma cells. Triggering of apoptosis per se in either cell type does not necessarily result in increased HIV gene expression. Most importantly, the apoptotic and HIV gene expression responses elicited by UV are different to some extent and can be separated.
Effect of Sidewall Contamination on Linear Cascades With Moving Bars (2005)

The effect of the nite extent of linear cascades on the unsteady pressure distribution due to the presence of moving bars is assessed by means of a numerical study. The height of a reference cascade made up of at plates has been changed to quantify its in uence. It is concluded that seven blades are enough to get rid of the contamination associated to the lateral walls of the cascade on the modulus of the unsteady pressure and that the resonant conditions of the cascade shall be avoided to improve its periodicity. The sidewall interference has been also studied for a representative low pressure turbine airfoil without signicantly modifying the conclusions obtained using at plates. The mode decomposition at the cascade exit shows also a reasonable matching with the periodic case.
Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution (2019)

The study was financed by grants from the Swedish state under the agreement between the Swedish government and the country councils, the ALF-agreement (ALFGBG-718611), the Gothenburg Medical Association GLS 694291 and 780821, the Swedish Heart Lung Foundation and Hjalmar Svensson Foundation. The authors have no conflict of interest.
Effect of preacceleration voltage upon ion-beam divergence (1978)

The effect of an insulator coating on the plasma electrode of a duoPIGatron ion source on ion-beam optics was examined theoretically and experimentally. The effect of a preacceleration potential, applied between the insulated electrode and the target cathode of the source plasma, on ion optics was also examined. A principal result is that this electrode arrangement with precel gives a much lower beam divergence than the same arrangement without precel. Detailed comparisons between the data and calculations are presented.
A human complement receptor 1 polymorphism that reduces<i>Plasmodium falciparum</i>rosetting confers protection against severe malaria (2003)

Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as "rosettes." Despite a well documented association between rosetting and severe malaria, it is controversial whether rosetting is a cause or a correlate of parasite virulence. CR1-deficient RBC show greatly reduced rosetting; therefore, we hypothesized that, if rosetting is a direct cause of malaria pathology, CR1-deficient individuals should be protected against severe disease. In this study, we show that RBC CR1 deficiency occurs in up to 80% of healthy individuals from the malaria-endemic regions of Papua New Guinea. This RBC CR1 deficiency is associated with polymorphisms in the CR1 gene and, unexpectedly, with alpha-thalassemia, a common genetic disorder in Melanesian populations. Analysis of a case-control study demonstrated that the CR1 polymorphisms and alpha-thalassemia independently confer protection against severe malaria. We have therefore identified CR1 as a new malaria resistance gene and provided compelling evidence that rosetting is an important parasite virulence phenotype that should be a target for drug and vaccine development.
Antiischemic Effect of Monophosphoryl Lipid A in Conscious Rabbits with Hypercholesterolemia and Atherosclerosis (1998)

We studied whether monophosphoryl lipid A (MLA), an endotoxin derivative, protected the heart from planned ischemia in hypercholesterolemic conscious rabbits. Normal and hypercholesterolemic (8-week exposure to 1.5% cholesterol-enriched diet) conscious rabbits with right ventricular electrode and left ventricular polyethylene catheters were subjected to ventricular overdrive pacing (VOP: 500 beats/min over 10 min = control VOP). The resulting intracavitary ST-segment elevation, increase in left ventricular end-diastolic pressure (LVEDP), and a reduction of ventricular effective refractory period (VERP) were measured. Three days later the animals were given a single intravenous bolus of 10 or 30 microg/kg MLA or its solvent or both, and a second VOP (test VOP) was applied 24 h later. MLA decreased ST elevation and LVEDP increase from 2.1 +/- 0.16 to 1.27 +/- 0.25 and 0.97 +/- 0.13 mV and 14.6 +/- 1.2 to 11.1 +/- 1.0 and 12.4 +/- 1.2 mm Hg in normal animals and from 2.55 +/- 0.14 to 1.31 +/- 0.12 and 0.96 +/- 0.30 mV and from 21.0 +/- 1.6 to 11.7 +/- 1.3 and 12.4 +/- 1.3 mm Hg in atherosclerotic animals after 10- and 30-microg/kg doses, respectively (p < 0.001 for each). VOP-induced VERP reduction was also significantly alleviated by both MLA doses; nevertheless, 30-microg/kg MLA significantly prolonged resting VERP with a slight VERP reduction in response to pacing in both normal and atherosclerotic animals. We conclude that MLA produces a delayed antiischemic effect in both normal and hypercholesterolemic/atherosclerotic conscious rabbits.
On the absolute stability of automatic control system with many nonlinear characteristics (1965)

Many authors, mainly in the Soviet, have discussed the absolute stability of the automatic control system with one nonlinear element. In practical problems, however, we sometimes encounter the control system with many nonlinear elements. In this paper the absolute stability of the automatic control system with many nonlinear elements is discussed. The discussions are based on the methods : 1. Lyapunov's direct method. 2. Popov's method. The relations between the results obtained by means of these two methods are also described.
Development of Barrier Anodic Oxide Al[sub 2]O[sub 3] Passivations of Aluminum Alloy Surface for LSI/FPD Plasma Process Equipment (2007)

Development of Barrier Anodic Oxide Al2O3 Passivations of Aluminum Alloy Surface for LSI/FPD Plasma Process Equipment, Kawase, Yasuhiro, Kitano, Masafumi, Mizutani, Fumikazu, Saeki, Masayuki, Shirai, Yasuyuki, Ohmi, Tadahiro
Macromolecular Complex Formation and Polymer Adsorption on Colloidal Particles in Aqueous Solution (1989)

Excimer fluorescence from pyrene groups labeled at the ends of poly(ethylene glycol) chains was used to monitor the configurational behavior of the probe chain during formation of macromolecular complexes with poly(methacrylic acid) or poly(acrylic acid) and during adsorption on colloidal silica or polystyrene colloidal particles in water. The excimer to monomer intensity ratio was separated into intramolecular and intermolecular contributions to follow the decrease in intramolecular cyclization probability during complex formation. Hydrophobic attractive interactions between the pyrene groups are suggested to occur for the free probe chain in water as well as with the compact poly(methacrylic acid) and the colloidal polystyrene particles. Excitation spectra provide significant qualitative information about the local environment of the pyrene rings.
ET-08 * DEMETHYLATING THERAPY INDUCES DIFFERENTATION AND THERAPEUTIC RESPONSE IN IDH1 MUTANT MALIGNANT GLIOMAS (2014)

Isocitrate Dehydrogenase 1 (IDH1) mutations are frequent in progressive GBMs and the grade II and III gliomas from which they arise. The mutant IDH1 enzyme pathologically produces 2-hydroxyglutarate (2-HG) that metabolically inhibits α-ketogluterate dependent histone and DNA demethylases. This results in abnormal hypermethylation of genomic DNA that subsequently suppress cellular differentiation. We have investigated the use of the FDA approved drug, 5-azacytidine, and have shown it to be an effective agent in two preclinical models of IDH1 mutant glioma. To accurately model the IDH1 mutation oncogenic process, we developed a patient derived IDH1 mutant anaplastic astrocytoma model which produces 2-HG and shows a hypermethylated genome. Using this genetically and molecularly accurate model we have demonstrated the preclinical efficacy and mechanism of action of the FDA approved demethylating drug 5-azacytidine in vivo. Long term administration of 5-azacytidine resulted in reduction of DNA methylation of promoter loci, induction of glial differentiation, reduction of cell proliferation and significantly reduced tumor growth. Nearly complete tumor regression was observed by 14 weeks, resulting in a sustainable response and significant survival benefit. The sequence of events leading to a therapeutic response in IDH1 mutant gliomas appear to be first, inactivation of DNMT1, Loci specific genome demethylation, key alterations in the gene expression pattern, cellular differentiation followed by growth arrest. Overall, our goal is to find the most effective combination strategy for forcing differentiation in IDH1 mutant gliomas. It is based on targeting the epigenetic mechanism of transformation specific to the tumor, and xenograft models that have the native mutation. In is hoped that the results from this work will allow a better clinical trial design specific for IDH1 mutant glioma, as well as key biomarkers for therapeutic response.
IgD multiple myeloma: A cure at 21 years (1988)

A 52-year-old man with a plasmacytoma of the body of T-10 in February 1965 returned 6 months later with multiple myeloma characterized by bone pain, osteolytic lesions, and IgD lambda monoclonal protein in the serum, 6.1 g of Bence Jones protein in the urine, and 21% plasma cells in the bone marrow. The M-protein and bone pain disappeared within 6 weeks after therapy with melphalan and prednisone was started. Therapy was discontinued in December 1974. Immunoelectrophoreses and immunofixations of the serum and urine over the years revealed no monoclonal protein. A mediastinal tumor developed, and the patient died of respiratory insufficiency on October 23, 1986. Autopsy revealed a large bronchogenic carcinoma of the right lung extending to the mediastinum, trachea, and esophagus. There was no evidence of multiple myeloma. This patient had responded rapidly to chemotherapy and had no recurrence of myeloma during a 21-year follow-up.
Ankle Flexors Produce Peak Torque at Longer Muscle Lengths after Whole-Body Vibration (2008)

This study shows that stretched human ankle plantarflexors respond to WBV by generating peak voluntary torque at longer muscle lengths. This has possible benefits for the rehabilitation of patients with neuromuscular disorders (e.g., stroke) who experience short ankle flexor resting lengths.
Blind adaptive noncoherent multiuser detection for nonlinear modulation (2000)

Noncoherent multiuser detection for nonlinear modulation was previously studied and the idea of phase-independent noncoherent decorrelation was introduced and three post-decorrelative detectors were obtained and analyzed. However, their implementation requires the knowledge of the signature waveforms of all the users, which may be available only for centralized implementation. In this paper, we obtain a blind adaptive noncoherent decorrelative detector for nonlinear modulation that is suitable for distributed implementation with the knowledge of only the normalized signals of the desired user and the additive noise variance. This detector is based on the stochastic approximation method and does not require the overhead of any kind of "training." Two adaptive algorithms are developed, one guided by every signal in the desired user's signal set individually, and the other by the user's entire signal space. While this paper focuses on the particular problem of blind adaptive noncoherent decorrelative detection, it addresses a more general adaptation issue, namely, that of improving the convergence properties of an adaptive scheme by effectively using all the information that is known, and adapting only to the part of the desired solution that is truly unknown. Convergence is shown in the mean squared error sense for both the fixed step-size and time-varying step-size versions of the two algorithms.
Prevalence of Lifestyle Risk Factors in Myotonic Dystrophy Type 1 (2013)

The results of this study will provide guidance for the development of better adapted and focussed health promotion interventions in the future.
Acute effects of corticosterone on BOLD signal: A pharmacological fMRI study in rats at 7 tesla (2004)

Thirteen adrenalectomized rats were examined by phMRI at 7 Tesla in order to map local changes in BOLD signal after an acute stress challenge with corticosterone (CORT, n=7) compared to vehicle injection (CON, n=6). Regional time courses of CORT versus CON showed a relative increase (1.0–1.2%) in BOLD signal in medial prefrontal cortex/anterior cingulate (mPFC/ACC). Averaged time courses of volume of interests identified post hoc in SPM map confirmed a positive response difference of CORT/CON in orbitofrontal cortex, caudate-putamen and mPFC/ACC. Acute rises of CORT appear to regionally increase BOLD signal being in line with stress-related activation of prefrontal circuits.
Combined Head and Abdominal Blunt Trauma: What Takes Priority? (2016)

Cho, Jayun MD; Benjamin, Elizabeth R. MD, PhD, FACS; Siboni, Stefano MD; Inaba, Kenji MD, FACS FRCSC; Demetriades, Demetrios MD, PhD, FACS Author Information
Data analysis of solar power installation project for Lee County'S T.K. Davis Justice Center (2010)

In the spring of 2009, Lee County's T.K. Davis Justice Center (LCJC) installed a 16.6 kW grid-connected solar-powered system to help offset the energy costs of electricity used by the facility. Detailed analysis of the PV array performance is being executed. Data analysis consists of efficiency with intensity, monthly and yearly performance comparisons of roof and pole arrays with PV modeling simulations, and the effect of weather, temperature, and different orientations on overall performance. This paper will also document the success story of Alabama's first State Government sponsored PV energy project. It can serve as a model of how local governments can be an example of how to increase energy-efficiency, be environmentally friendly, and reduce operational costs over the long-term.
Nouvelle méthode d'authentification EAP-EHash (2006)

Cet article présente une nouvelle méthode EAP appelée EAP-EHash (EHash pour Encrypted-Hash) qui allie la simplicité et la facilité de déploiement de EAP-MD5 et la robustesse de EAP-TLS. Elle se positionne dans les mêmes domaines d'application que ces deux méthodes EAP existantes (authentification d'utilisateurs à des serveurs, VPN...). Pour un meilleur positionnement de ces méthodes, l'article présente les deux méthodes EAP-TLS et EAP-MD5, puis EAP-EHash et effectue pour chacune une analyse critique. Enfin, la méthode EAP-EHash est validée formellement à l'aide de l'outil AVISPA, ce qui prouve qu'elle vérifie bien les propriétés de sécurité désirées, en particulier sa robustesse à l'attaque Man-In-The- Middle.
Effects of Salinity, Imazethapyr, and Chlorimuron Application on Soybean Growth and Yield (2005)

Abstract Soybean is an important crop worldwide. Soybean cultivars differ in their sensitivity to soil salinity and herbicide damage. In these experiments, we examined the impact of salinization and herbicide (imazethapyr and chlorimuron) application on the growth and yield of two soybean cultivars, Essex and Manokin. Experiments were conducted in small pots in the greenhouse, in outdoor sand cultures, and in drip‐irrigated field plots. Plants were irrigated with non‐saline water or saline water (electrical conductivity, EC=7 dS/m) with a composition typical of those in areas affected by sulfate‐dominated salinity. Morphological changes resulted from herbicide application, including leaf elongation and formation of large shoots at the cotyledonary node. Herbicide treatment significantly reduced main stem height, number of nodes on the main stem, and stem diameter relative to the controls (not treated with herbicide); responses from the two herbicides were not significantly different. Salinity had a significant effect on seed weight: yield for “Essex” (a Cl accumulator) was significantly higher when irrigated with fresh water, while yield for “Manokin” (a Cl excluder) was significantly larger for plants irrigated with saline water. Yield for “Essex” was greater than that for “Manokin” when the plants were irrigated with fresh water; but at the higher irrigation water salinity (7 dS/m), “Manokin” produced significantly greater yield than “Essex.” Although herbicide application significantly impacted several growth variables, herbicide treatment had no significant impact on yield.
Ovarian Adenocarcinoma Presenting as Axillary Lymphadenopathy (2010)

Introduction Ovarian adenocarcinoma is the fifth leading cause of death for women in the United States, with an estimated 15,520 deaths per year. 1 However, ovarian adenocarcinoma presenting as axillary lymphadenopathy is quite a rare occurrence. This case documents an ovarian adenocarcinoma presenting as axillary lymphadenopathy, with a focus on the importance of the surgeon differentiating the axillary mass from metastatic breast cancer.
A new method for observing the rotational spectra of weak molecular complexes: KrHCl (1980)

A new method of observing the rotational transitions of weak molecular complexes by combining the techniques of microwave Fourier transform spectroscopy, a Fabry–Perot cavity, and a pulsed nozzle source of molecules is described. High resolution and good sensitivity are achieved. Twelve isotopic species of the KrHCl molecule involving all combinations of the 86Kr, 84Kr, 82Kr, H, D, 35Cl, and 37Cl isotopes are assigned and the rotational constants, Cl nuclear quadrupole coupling constants, and centrifugal distortion constants are all given. The molecular structure indicates a linear equilibrium structure with the H(D) atom between the Kr and Cl atoms. However, the inverse moments of inertia measured here indicate large amplitude vibrations of the H(D) atom relative to the Kr–Cl internuclear line. Estimates of the Kr–Cl stretching frequency and force constants, which show considerable dependence on the isotopic species, are also given. Bending frequencies and force constants are also given.
Evaluation of Alternatives to Carbamate and Organophosphate Insecticides Against Thrips and<i>Tomato Spotted Wilt Virus</i>in Peanut Production (2015)

Thrips are important pests of peanut. They cause severe feeding injuries on peanut foliage in the early season. They also transmit Tomato spotted wilt virus (TSWV), which causes spotted wilt disease. At-plant insecticides and cultivars that exhibit field resistance to TSWV are often used to manage thrips and spotted wilt disease. Historically, peanut growers used the broad-spectrum insecticides aldicarb (IRAC class 1A; Temik) and phorate (IRAC class 1B; Thimet) for managing thrips and thereby reducing TSWV transmission. Aldicarb has not been produced since 2011 and its usage in peanut will be legally phased out in 2018; therefore, identification of alternative chemistries is critical for thrips and spotted wilt management. Here, eight alternative insecticides, with known thrips activity, were evaluated in field trials conducted from 2011 through 2013. In addition, different application methods of alternatives were also evaluated. Imidacloprid (Admire Pro), thiamethoxam (Actara), spinetoram (Radiant), and cyantraniliprole (Exirel) were as effective as aldicarb and phorate in suppressing thrips, but none of the insecticides significantly suppressed spotted wilt incidence. Nevertheless, greenhouse assays demonstrated that the same alternative insecticides were effective in suppressing thrips feeding and reducing TSWV transmission. Spotted wilt incidence in the greenhouse was more severe (∼80%) than in the field (5–25%). In general, field resistance to TSWV in cultivars only marginally influenced spotted wilt incidence. Results suggest that effective management of thrips using alternative insecticides and subsequent feeding reduction could improve yields under low to moderate virus pressure.
Multistress endurance characterization of EPR cable models (2002)

The results of life tests performed on EPR cable models aged by combined thermal-electrical stresses are reported, showing electrical and thermal life lines, intersections of the life surface with the planes at constant stress. The Combined Analysis Method (CAM) is used to obtain more information on the behavior of the tested cable in a wide voltage and temperature range. Parameters useful for insulation characterization and cable design are derived.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Expression of Collagen‐Binding Protein and Types 5 and 8 Capsular Polysaccharide in Clinical Isolates of<i>Staphylococcus aureus</i> (1997)

In vitro collagen binding of 216 Staphylococcus aureus isolates from patients with various diagnoses was studied. Polymerase chain reaction was used to examine these isolates regarding the existence of the corresponding cna gene. Distribution of capsular polysaccharide (CP) types was examined. Fifty-six (57%) of 99 S. aureus isolates from patients with endocarditis or bacteremic bone or joint infection were cna-positive compared with 65 (56%) of 117 isolates from bacteremic patients without signs of bone or joint infection (P = .99). There was a good correlation between in vitro collagen binding and presence of the cna gene. These data suggest that collagen binding is not a prerequisite for the development of endocarditis, osteomyelitis, or septic arthritis. There was no significant difference in the distribution of CP types among various patient groups, although there was a strong association between CP type 8 and the existence of the cna gene.