gebhart/patrepeval huggingface dataset:
Estimated Prevalence of Ocular Toxoplasmosis and Toxocariasis in Alabama (1987)

Journal Article Estimated Prevalence of Ocular Toxoplasmosis and Toxocariasis in Alabama Get access H. Michael Maetz, H. Michael Maetz Department of Epidemiology, School of Public Health and the School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert N. Kleinstein, Robert N. Kleinstein Department of Epidemiology, School of Public Health and the School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama Search for other works by this author on: Oxford Academic PubMed Google Scholar Deborah Federico, Deborah Federico Department of Epidemiology, School of Public Health and the School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama Search for other works by this author on: Oxford Academic PubMed Google Scholar John Wayne John Wayne Department of Epidemiology, School of Public Health and the School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 156, Issue 2, August 1987, Page 414, https://doi.org/10.1093/infdis/156.2.414 Published: 01 August 1987
Heavy-traffic-optimal scheduling with regular service guarantees in wireless networks (2013)

We consider the design of throughput-optimal scheduling policies in multi-hop wireless networks that also possess good mean delay performance and provide regular service for all links -- critical metrics for real-time applications. To that end, we study a parametric class of maximum-weight type scheduling policies with parameter α ≥ 0, called Regular Service Guarantee (RSG) Algorithm, where each link weight consists of its own queue-length and a counter that tracks the time since the last service. This policy has been shown to be throughput-optimal and to provide more regular service as the parameter α increases, however at the cost of increasing mean delay.
High Temperature Materials – Their development and prospects – (1990)

Abstract A brief description of the requirements for materials to be used in high temperature applications is given. The main types of high temperature materials, i.e. alloys, refractory metals, coatings and ceramics are presented both in terms of present status and future prospects. Suggestions for research efforts in the field of high temperature materials are outlined.
Initial results teaching and learning in the Integrated Teaching and Learning Lab (ITLL) (1997)

Summary form only given. The University of Colorado's College of Engineering and Applied Science (USA) is in the fifth year of a College-wide program that models the real world of engineering where skills in communication, teamwork and leadership, as well as the ability and self confidence to define and solve open ended problems, are demanded. This paper describes how a team of faculty and students defined and realized an ambitious vision for undergraduate engineering education reform which uses an integrated teaching and learning laboratory.
Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-κB Activation (2013)

Antigen receptors activate pathways that control cell survival, proliferation, and differentiation. Two important targets of antigen receptors, NF-κB and Jun N-terminal kinase (JNK), are activated downstream of CARMA1, a scaffolding protein that nucleates a complex including BCL10, MALT1, and other IκB kinase (IKK)-signalosome components. Somatic mutations that constitutively activate CARMA1 occur frequently in diffuse large B cell lymphoma (DLBCL) and mediate essential survival signals. Mechanisms that downregulate this pathway might thus yield important therapeutic targets. Stimulation of antigen receptors induces not only BCL10 activation but also its degradation downstream of CARMA1, thereby ultimately limiting signals to its downstream targets. Here, using lymphocyte cell models, we identify a kinase-independent requirement for TAK1 and its adaptor, TAB1, in antigen receptor-induced BCL10 degradation. We show that TAK1 acts as an adaptor for E3 ubiquitin ligases that target BCL10 for degradation. Functionally, TAK1 overexpression restrains CARMA1-dependent activation of NF-κB by reducing BCL10 levels. TAK1 also promotes counterselection of NF-κB-addicted DLBCL lines by a dual mechanism involving kinase-independent degradation of BCL10 and kinase-dependent activation of JNK. Thus, by directly promoting BCL10 degradation, TAK1 counterbalances NF-κB and JNK signals essential for the activation and survival of lymphocytes and CARMA1-addicted lymphoma types.
Mars-Moons Exploration, Reconnaissance, and Landed Investigation (MERLIN) (2016)

MERLIN, the Mars-Moons Exploration, Reconnaissance and Landed Investigation, is a concept for the first mission to land on the Martian moon Phobos and the first U.S. mission to conduct an in situ investigation of a D-type body typical of the outer solar system. Understanding Phobos and Deimos provides key information for understanding the history and evolution of our solar system and drives MERLIN's combined orbital and landed mission design. MERLIN would perform 9 months of orbital reconnaissance of Phobos and Deimos, characterizing their geology and a landing site on Phobos. Once landed, MERLIN would perform 90 days of complementary measurements of chemical and mineralogic composition. Phobos' size and mass provide a low-risk landing environment for a small-body lander. Controlled descent is so slow that the landing can be rehearsed and even repeated, yet gravity is high enough that surface operations do not require anchoring. Imaging of Phobos from past missions demonstrates the existence of regions suitable for landing and provides knowledge for planning the orbital and landed investigations. MERLIN's dual orbital and landed data would deliver seminal science directly traceable to NASA's Strategic Goals and Objectives, NASA's Science Plan, and Decadal Survey goals, while simultaneously closing strategic knowledge gaps (SKGs) to prepare for future human exploration. MERLIN's landed compositional measurements would unravel the origin of Mars' moons, addressing the goal to understand how solar system objects formed and evolved. MERLIN would determine the inventory of prebiotic materials on Phobos, addressing the goal focused on the distribution of volatiles and organics across the solar system, and the origin and requirements of life. MERLIN's high-resolution images during low flyovers would investigate processes that affect the local regolith and provide geologic context for landed measurements. MERLIN would characterize the geology, surface regolith, and internal structure of Mars' moons, addressing the goal to understand processes that shape planetary bodies, and how those processes operate and interact. MERLIN's combined remote and landed investigations would deliver pioneering data about Phobos, characterizing an object on the flexible path for human exploration.
Arthroscopically assisted acromioclavicular joint stabilization leads to significant clavicular tunnel widening in the early post‐operative period (2019)

IV.
Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor‐negative breast cancer (2014)

Our findings suggest potential mechanistic actions of tea polyphenols in growth factor signalling, angiogenesis and lipid metabolism.
Diminished Systemic and Antigen-Specific Type 1, Type 17, and Other Proinflammatory Cytokines in Diabetic and Prediabetic Individuals With Latent<i>Mycobacterium tuberculosis</i>Infection (2014)

Our data reveal that latent infection in the presence of DM or pre-DM, is characterized by diminished production of cytokines, implicated in the control of M. tuberculosis activation, allowing for a potential immunological mechanism that could account for the increased risk of active tuberculosis in latently infected individuals with DM.
Tumor Staging But Not Grading Is Associated With Adverse Clinical Outcome in Neuroendocrine Tumors of the Appendix (2013)

Appendiceal neuroendocrine neoplasms (NENs) are rare and usually incidentally discovered. Most cases are clinically indolent, although the rare aggressive ones are poorly predictable. The aim of this study was to test the applicability and prognostic significance of the new World Health Organization (WHO) classification and to test the several pathologic features and TNM staging systems (American Joint Committee on Cancer and European Neuroendocrine Tumor Society) in these tumors. A multi-institutional retrospective series of 138 appendiceal NENs was selected on the basis of the availability of both pathologic material and clinical information, including follow-up data. All cases were reviewed to record pathologic features and to apply year 2000 and 2010 WHO classifications, as well as European Neuroendocrine Tumor Society and American Joint Committee on Cancer TNM stages. Clinical and pathologic characteristics were compared with disease outcome by contingency, univariate, and multivariate survival analyses. Although up to one third of cases presented several malignancy-associated pathologic features, only 4 patients died of the disease. Adverse outcome was significantly associated with extramural extension (including mesoappendix), well-differentiated carcinoma diagnosis (2000 WHO classification), pT3-4 stage, older age, and presence of positive resection margins, but not with tumor size, mitotic or proliferative indexes, and, consequently, 2010 WHO grading. In the appendix, at variance with midgut/hindgut NENs, the 2000 WHO classification performs better than the grading-based 2010 WHO scheme and, together with tumor stage, is the most relevant parameter associated with clinical aggressiveness.
Latest expertise investigations in nuclear dismantling and industrial applications (2013)

During the last decades, CANBERRA has developed know-how, expertise and intervention strategies based on its feedback experiences in many countries. This document covers a wide range of applications involving nuclear characterization, for which CANBERRA is able to provide measurement set-up and results, activity characterization and radioactive source localization, as well as to guarantee safety or process thresholds corresponding to the customer's needs. To improve processes best-in-class methodology, know-how and tools have been used in complex examples described in this paper. CANBERRA has demonstrated its ability to better and efficiently prepare for and execute decontamination and dismantling activities.
Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol 7 alpha-hydroxylase gene expression (1997)

Cholesterol 7 alpha-hydroxylase (cyp7) is the rate-limiting enzyme in bile acid biosynthesis. Previously, dietary cholesterol was shown to induce cyp7 gene expression. However, recent studies have produced data that are inconsistent with this observation, suggesting the possibility that other factors in the diet are also important in the regulation of cyp7 by dietary cholesterol. The effect of dietary fats on the ability of dietary cholesterol to regulate cyp7 activity and mRNA abundance was assessed. High fat diets composed primarily of polyunsaturated (PUFA), monounsaturated (MUFA), or saturated (SFA) fatty acids induced hypercholesterolemia regardless of whether cholesterol was present or not. However, the effects of each diet on bile composition and hepatic cholesterol content were variable. Microsomal fatty acid profiles reflected the fatty acid composition of the diets. Addition of cholesterol to the PUFA diet increased cyp7 mRNA abundance and activity, analogous with the results observed in mice fed a chow plus cholesterol diet. On the other hand, addition of cholesterol to diets high in MUFA or SFA caused a significant reduction of cyp7 mRNA abundance and activity. Addition of cholesterol to all the diets caused the expected changes in low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA abundance but was not correlated with the changes in cyp7 mRNA abundance. The relationship between cyp7 mRNA abundance and hepatic total cholesterol content or hepatic microsomal cholesterol content was evident, suggesting that cholesterol status does not necessarily determine cyp7 mRNA abundance. The results of this study illustrate that the type of dietary fat is important in elaborating the regulatory potential of dietary cholesterol on cyp7 gene expression and suggest that the regulation of cyp7 gene expression does not involve the classical sterol-mediated pathway.
Sterically Stabilized Vesicles (1994)

Abstract After significant developments in liquid crystal and polymer research, scientists became interested in lyotropic systems containing polymers. These studies investigated, for instance, phase behavior and stability characteristics of suspensions of colloidal particles containing water‐soluble or surface‐adsorbed polymers or block copolymers. The most frequently studied were micelles, latex prticles, and lipid vesicles (liposomes). Liposomes aggregate and fuse in the presence of hydrophilic polymers but their properties were difficult to explain when block copolymers were adsorbed or surfactants with larger polymeric polar heads were inserted into the liposome membrane, because such systems are inherently ill defined. Liposomes containing diacyl surfactants with covalently linked, longer polymer chains display many new properties with very important consequences for both basic and applied research. They stimulate fundamental studies on phase behavior and polymer conformation, scaling laws, colloidal and surface properties, and cell function: applications deal predominantly with liposomes as drug delivery systems. While in basic research theory is currently more advanced than experiment, in medical applications theoretical understanding lags behind experimental achievements. It was discovered only relatively late that liposomes with an appropriate polymer coating are significantly more stable in a biological milieu, a necessary condition for their utility as drug carriers. In particular in medical applications, this practice has rejuvenated the field of anticancer therapy and targeted drug deliviery. All these advances were made possible by an effective and synergistic overlap of many different disciplines.
Effect of Blade Tip Clearance on Turbine Shroud Heat/Mass Transfer (2001)

This study investigates the local heat/mass transfer characteristics on the stationary shroud with blade tip clearances for flat tip geometry. A large scale linear cascade is used and the relative motion between the blade and shroud is neglected in this study. A naphthalene sublimation method is employed to determine the detailed local heat/mass transfer coefficients on the shroud surface. The geometry of blade tip used in this study is flat and the tip clearance varies from 0.66% to 2.85% of the blade chord length. The flow enters the gap between the blade tip and shroud at the pressure side due to the pressure difference. Therefore, the heat/mass transfer characteristics on the shroud are changed significantly from those for no tip clearance. High heat/mass transfer region is observed along the pressure side of blade due to the entrance effect and the acceleration of the tip gap flow. Complex heat transfer patterns on the shroud are observed in the region where the blade tip and shroud are overlapped due to the flow separation and reattachment. Then, the heat/mass transfer coefficients on the shroud increase along the suction side of blade because tip leakage vortices are generated with interacting the main flow. The experimental results show that the heat/mass transfer characteristics are changed significantly with the gap distance between the tip of turbine blade and the shroud. However, the turbulence intensity of incoming flow has little influence on the heat/mass transfer coefficients on the shroud with tip clearance.
Improving success rate of hydrogen-bond driven synthesis of co-crystals (2006)

Increasing the negative charge of a hydrogen-bond acceptor using electron-donating substituents offers a significant improvement in hydrogen-bond driven synthesis of carboxylic acid⋯N-heterocycle co-crystals.
ChemInform Abstract: Asymmetric Copper‐Catalyzed Synthesis of α‐Amino Boronate Esters from N‐tert‐Butanesulfinyl Aldimines. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digoxin Immune Fab Treatment for Severe Preeclampsia (2010)

We evaluated the efficacy, safety, and biological mechanisms of digoxin immune Fab (DIF) treatment of severe preeclampsia. Fifty-one severe preeclamptic patients were randomized in double-blind fashion to DIF ( N = 24) or placebo ( N = 27) for 48 hours. Primary outcomes were change in creatinine clearance (CrCl) at 24 to 48 hours and antihypertensive drug use. Serum sodium pump inhibition, a sequela of endogenous digitalis-like factors (EDLF), was also assessed. CrCl in DIF subjects was essentially unchanged from baseline versus a decrease with placebo (-3 +/- 10 and -34 +/- 10 mL/min, respectively, P = 0.02). Antihypertensive use was similar between treatments (46 and 52%, respectively, P = 0.7). Serum sodium pump inhibition was decreased with DIF compared with placebo at 24 hours after treatment initiation (least squares mean difference, 19 percentage points, P = 0.03). DIF appeared to be well tolerated. These results suggest DIF prevents a decline in renal function in severe preeclampsia by neutralizing EDLF. Sodium pump inhibition was significantly improved. Further research is warranted.
The avian malaria<i>Plasmodium lophurae</i>has a small number of heterogeneous ribosomal RNA genes (1983)

The structure and number of the ribosomal RNA (rRNA) genes of the avian malaria parasite Plasmodium lophurae has been examined using Southern blot analysis and recombinant DNA techniques. The ribosomal DNA (rDNA) of P. lophurae has been cloned into the plasmid pBR322, beginning with size-selected populations of Cla I- and Hind III-restricted parasite DNA. The structure of two clones (CL-1 and HA-2) is presented in detail. These two clones together probably represent the entire 17s and 25s coding regions of P. lophurae. Analysis of quantitative genomic Southern blots reveals that there are approximately six rRNA genes per haploid genome, and that the rRNA genes may be divided into four distinct classes by restriction analysis. Examination of the flanking regions of these genes indicates that they are not organized into easily recognizable tandem repeats.
Practical Techniques for Language Design and Prototyping (2005)

Global computing involves the interplay of a vast variety of languages, but practially useful foundations for language specification and prototyping at the semantic level are lacking. In this talk we present a systematic approach consisting of three techniques: 1. A generic calculus of explicit substitutions with names (called CINNI) that allows us give a first-order representation of syntax to uniformly deal with all binding aspects. 2. An executable representation of Felleisen-style operational semantics in terms of first-order rewrite rules. 3. A logical framework, namely rewriting logic, that allows us to express (1) and (2) and, in addition, language aspects such as concurrency and non-determinism. We illustrate the use of these techniques in two applications: 1. A formal specification and analysis of PLAN, a Packet Language for Active Networks, that has been developed in the Switchware project at UPenn. This work was conducted in the scope of the DARPA Active Network Program. 2. The development of CIAO, a Calculus of Imperative Active Objects, a core language for concurrent object-oriented programming. It is especially designed to allow a the representation of practically relevant sublanguages of common object-oriented languages such as Java, C#, and C++. This second application is subject of ongoing work.
Can Bluetooth succeed as a large-scale ad hoc networking technology? (2005)

We investigate issues that Bluetooth may face in evolving from a simple wire replacement to a large-scale ad hoc networking technology. We do so by examining the efficacy of Bluetooth in establishing a connected topology, which is a basic requirement of any networking technology. We demonstrate that Bluetooth experiences some fundamental algorithmic challenges in accomplishing this seemingly simple task. Specifically, deciding whether there exists at least one connected topology that satisfies the Bluetooth constraints is NP-hard. Several implementation problems also arise due to the internal structure of the Bluetooth protocol stack. All these together degrade the performance of the network, or increase the complexity of operation. Given the availability of efficient substitute technologies, Bluetooth's use may end up being limited to small ad hoc networks.
Synthesis of poly(arylene ether)s containing hole-transport moieties from an isocyanate masked bisphenol (2000)

The design and synthesis of novel charge (hole- or electron-) transport materials have been the focus of much research in recent years because of their wide variety of applications. In this study, three high molecular weight poly(arylene ether)s, 6a–c, containing naphthyl-substituted benzidine moieties have been synthesized from carbamates derived from bisphenols. After masking with n-propyl isocyanate, the carbamate is stable, can be readily purified by recrystallization from toluene, and can be polymerized directly with difluoro compounds under mild conditions. The resulting polymers possess high glass-transition temperatures, excellent thermal stability, and good film-forming properties. In comparison, the poly(arylene ether)s 6a′–c′, synthesized from unprotected bisphenol, have lower molecular weights and wider polydispersity and contain some brown impurities. Preliminary experiments show that both 6a and 6a′ can function well as hole-transport materials in light-emitting diodes. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 2740–2748, 2000