gebhart/patrepeval huggingface dataset:
Necrotizing Fasciitis: Diagnostic Challenges in a Mute Bedridden Patient with Atypical Laboratory Parameters (2012)

A 27-year-old mute bedridden patient required parenteral corticosteroids and antibiotics, and hospitalization for an acute respiratory illness. After 2 days, staff noted a ~0.3 cm blister on the patient's right heel. Within 19 hours, blistering increased and the foot became partly gangrenous. The patient developed high fever (40.3°C), and leukocytosis (count: 13 × 10(9)/L; was 6.5 × 10(9)/L ten days earlier). Necrotizing fasciitis (NF) was diagnosed and treated with emergency leg amputation. Histopathology revealed necrosis of fascia, muscle, subcutaneous tissue, and skin. In bedridden patients, corticosteroids may particularly facilitate serious infections, and initial NF blistering may be mistaken for pressure ulcers. Vigilant and frequent whole body monitoring is necessary for all patients incapable of verbalizing their symptoms.
Molecular Cloning and Expression of Rhesus Macaque and Sooty Mangabey Interleukin 16: Biologic Activity and Effect on Simian Immunodeficiency Virus Infection and/or Replication (1998)

Interleukin 16 (IL-16) has been shown to diminish HIV and SIV replication through inhibition of HIV and SIV mRNA transcription. To evaluate its role further, we compared IL-16 cloned from disease-susceptible rhesus macaques and disease-resistant sooty mangabeys. Recombinant rhesus macaque (rr) IL-16 was compared with recombinant sooty mangabey (rm), human, and other nonhuman primate IL-16 sequences and evaluated for its ability to induce chemotaxis and inhibit the mixed lymphocyte response (MLR). Also, rrIL-16 and rmIL-16 were evaluated for suppression of SIVmac251, which replicates efficiently in T cells and monocyte/macrophages (dual tropic), and cloned SIVmac239, which replicates efficiently in T cells (T tropic). Sequence comparison of rrIL-16 and rmIL-16 with human IL-16 showed >97% amino acid identity. Biocharacterization of rrIL-16 revealed potent induction of chemotaxis (p < 0.05) and marked inhibition of MLR (73 +/- 0.6%,p < 0.05) in rhesus and human cell systems. Using rrIL-16 and rmIL-16, p27 antigen production from PBMCs infected with SIVmac251 was decreased up to 70% (p < 0.05 and p < 0.01, respectively). In similar cultures infected with SIVmac239, rrIL-16 and rmIL-16 reduced p27 levels by 96 and 100%, respectively. These data demonstrate the biologic and antiviral functionality of rrIL-16 and rmIL-16.
ChemInform Abstract: Acylketene Acetals in Organic Synthesis. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Simple and Effective Method of Evaluating Atomic Force Microscopy Tip Performance (2000)

The morphology of a surface imaged by dynamic force mode atomic force microscopy is obtained through an interaction between the probe tip and surface features. When the tip is contaminated and the size of the contaminant is comparable to the size of the features on the sample surface, artifacts attributable to the contaminant are observed to dominate the image. To reduce the possibility of effects from such artifacts, the tip performance should be checked by scanning a reference sample of known surface morphology. We demonstrate a simple and effective method of evaluating tip performance by the imaging of a commercially available biaxially oriented polypropylene (BOPP) film, which contains nanometer-scale-sized fibers. This sample is appropriate for use as a reference because a contaminated tip will not detect the fiberlike network structure. In addition, BOPP has a soft, highly hydrophobic surface of low surface energy, thus ensuring that the tip will not be damaged or contaminated during the evaluation process.
CXCL12 expression by invasive trophoblasts induces the specific migration of CD16– human natural killer cells (2003)

In the maternal decidua, natural killer (NK) cells, characterized by lack of CD16, are found in direct contact with the fetal extravillous trophoblasts (EVTs). It is yet unknown which factors contribute to the specific homing of this unique NK subset to the decidua. In this study we analyze the chemokine receptor repertoire on various NK populations derived from the peripheral blood and decidua. We show that CXCR4 and CXCR3 receptors are preferentially expressed on CD16- NK subsets derived either from the peripheral blood or the decidua and that these receptors are involved in migration of all NK subsets to their ligands. We further demonstrate in vivo that invading EVTs that eventually perform endovascular invasion express CXCL12, the ligand for CXCR4, but not ligands for CXCR3. Indeed, specific accumulation of the CD16- NK cells at the expense of CD16+ cells was observed only when in vitro migration was performed with ligands for CXCR4. Finally, incubation of the peripheral blood CD16- NK cells with cytokines present in the decidua, especially interleukin 15 (IL-15), resulted in the expression of chemokine receptor repertoire similar to that observed on decidual NK cells, suggesting an additional important regulatory effect of local decidual cytokines.
Leptin Constrains Phospholipase C-Protein Kinase C-Induced Insulin Secretion via a Phosphatidylinositol 3-Kinase-Dependent Pathway (2003)

Leptin-deficient Lep(ob)/Lep(ob)mice hypersecrete insulin in response to acetylcholine stimulation of the phospholipase C-protein kinase C (PLC-PKC) pathway, and leptin constrains this hypersecretion. Leptin has been reported to activate phosphatidylinositol 3-kinase (PI 3-K) and subsequently phosphodiesterase (PDE) to impair protein kinase A (PKA)-induced insulin secretion from cultured islets of neonatal rats. We determined if PKA-induced insulin secretion was also hyperresponsive in islets from Lep(ob)/Lep(ob)mice, and if leptin impaired this pathway in islets from these mice. Additionally, the possible role for PI 3-K and PDE in leptin-induced control of acetylcholine-induced insulin secretion was examined. Stimulation of insulin secretion with GLP-1, forskolin (an activator of adenylyl cyclase), or IBMX (an inhibitor of PDE) did not cause hypersecretion of insulin from islets of young Lep(ob)/Lep(ob)mice, and leptin did not inhibit GLP-1-induced insulin secretion from islets of these mice. Inhibition of PDE with IBMX also did not block leptin-induced inhibition of acetylcholine-mediated insulin secretion from islets of Lep(ob)/Lep(ob)mice. But, preincubation of islets with wortmannin, an inhibitor of PI 3-K activity, blocked the ability of leptin to constrain acetylcholine-induced insulin secretion from islets of Lep(ob)/Lep(ob)mice. We conclude that the capacity of the PKA pathway to stimulate insulin secretion is not increased in islets from young Lep(ob)/Lep(ob)mice, and that leptin does not regulate this pathway in islets from mice. Leptin may stimulate PI 3-K to constrain PLC-PKC-induced insulin secretion from islets of Lep(ob)/Lep(ob)mice.
Synthesis, Structure, and Significance for MOCVD of Intramolecularly Base-Stabilized Monomeric Cyclopentadienylaluminum and -gallium Dihydrides (2000)

The (N,N-dialkylaminoethyl)cyclopentadienyl group 13 element dichlorides 3 and 4 of the type [(R2NCH2CH2)C5H4]MCl2 {M = Al, R = Me (3); M = Ga, R = i-Pr (4)} were prepared via salt elimination reactions of [(R2NCH2CH2)C5H4]K {R = Me (1), i-Pr (2)} with the respective group 13 element trichlorides. The reaction of 3 with LiAlH4 afforded the cyclopentadienylaluminum dihydride [(Me2NCH2CH2)C5H4]AlH2 (5) in nearly quantitative yield. Treatment of the organogallium dichlorides [(R2NCH2CH2)C5H4]GaCl2 {R = i-Pr (4), Me (6)} with LiAlH4 led via transmetalation to the organoaluminum dihydrides [(R2NCH2CH2)C5H4]AlH2 {R = Me (5), i-Pr (7)} in good yields. The reaction of 6 with LiGaH4 resulted in the formation of the organogallium dihydride [(Me2NCH2CH2)C5H4]GaH2 (8). The novel compounds 3−5, 7, and 8 were characterized by elemental analysis, NMR spectroscopy, mass spectrometry, and X-ray crystallography. In the solid state and also in solution, all compounds feature a monomeric structure with an intramolecularly coordinated dialkylamino group. The coordinative and electronic saturation of the metal center in these compounds leads to a drastically decreased reactivity toward moisture and air in comparison to nondonor-stabilized Cp−group 13 element compounds. The dynamic behavior observed in solution is based on fast haptotropic shifts in a “windshield-wiper” type process. Sufficient volatility makes the organodihydrido compounds 5 and 8 suitable precursors for the deposition of aluminum and gallium, respectively, in the MOCVD process. Ex-situ characterization with sputter auger electron spectroscopy (SAES) provides information about the chemical composition of the aluminum and gallium layers. Irradiation of 5 and 8 in solution is followed by decomposition into the respective metal and into the hydrogen-functionalized ligand [C5H5(CH2CH2NMe2)].
All-glass Leakage Channel Fibers with Fluorine-doped Silica Pump Cladding (2009)

Direct amplification of ultra short pulses at 1037nm from fiber-oscillators to average powers of ~100 W at 48 MHz is demonstrated using single-stage amplifiers comprising new all-glass-leakage-channel-fibers, providing >70% slope efficiency and >33 dB gain.
ALPA WINS SCAB SUIT. (1993)

ASUIT ACCUSING POSTSTRIKE HARASSMENT BROUGHT BY TWO UNITED PILOTS CROSSING 1985 PICKET LINE.
Assessing the impact of demand management on the viability of polygeneration at the urban scale (2010)

Future cities are likely to be characterised by deployment of new and renewable energy systems. Maximum impact will be achieved where local schemes are designed to reduce the load being imposed on the public supply networks for electricity (and, in some cases, heat) or, conversely, be configured as dispatchable generation to facilitate active control at the request of network operators. This paper elaborates a modelling method whereby the match between demand at any urban scale and a hypothesised supply, comprising a mix of technologies for heat and electricity generation – so-called polygeneration – may be assessed, including the impact of demand management to improve the match.
ChemInform Abstract: Formation and Structures of Dimeric Compounds from an (E)‐5,5′‐Diphenyl‐2,2′,3,3′‐tetrahydro‐3,3′‐bipyrrolylidene‐2,2′‐dione. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Disruption of the Purine Nucleotide Cycle (1980)

A patient with symptoms of easy fatigability, postexercise myalgias, and delayed recovery of muscle strength after activity is described. Skeletal muscle from this patient had <1.0% normal myoadenylate deaminase activity and NH(3) was not released from muscle after ischemic exercise. In association with this enzyme deficiency, exercise led to a >90% reduction in muscle content of adenine nucleotides. No inosine monophosphate accumulated after exercise and total purine content of the muscle fell to 21% of control. Repletion of the adenine nucleotide pool in this patient was delayed compared to controls, and ATP content had only returned to 68% of control at 165 min after exercise. These studies demonstrate that disruption of the purine nucleotide cycle as a consequence of myoadenylate deaminase deficiency results in marked alterations in ATP content of muscle, and potentially, these changes in ATP content could account for muscle dysfunction in this patient.
Conducting Polymer Hydrogels: A Single Component Conducting Polymer Hydrogel as a Scaffold for Tissue Engineering (Adv. Funct. Mater. 13/2012) (2012)

On page 2692 Damia Mawad, Gordon G. Wallace, and co-workers report the development of a single-component conducting polymer (CP) hydrogel that combines both electroproperties and hydrogel characteristics, i.e., electroactivity at physiological pH and temperature, a notable swellingratio, and a porous internal structure. The CP hydrogel is also shown topromote cell adhesion and proliferation, opening the way for the development of new tissue engineering scaffolds for nerve and muscle regeneration.
Neuropeptidases regulating gonadal function (2000)

The generation and metabolism of bioactive peptides involves a series of highly ordered proteolytic events. This post-translational processing can occur either within the cell, at the cell surface or after secretion. In the central nervous system a number of extracellular peptidases have been implicated in the regulated processing of peptides, particularly in the regulation of neuroendocrine function. The aim of this study has been to identify the peptidases involved in the metabolism of gonadotropin-releasing hormone (GnRH) and to characterize the factors and the mechanisms by which the activity of these peptidases are regulated. We have shown that both prolylendopeptidase and the thimet oligopeptidase EC 3.4. 24.15 are involved in GnRH metabolism and that both oestrogen and thiol-based reductants could be involved in the physiological regulation of their activities.
Philosophical Conception in the Art of Calligraphy (2005)

The thought that art is based on morality while morality is attained through art is whith to be the main idea in the Chinese classic aesthetics, and viewing the relation between morality and art this way is the thought mindset of Chinese philosophers. The Chinese calligraphic theory is, on the whole, composed of a series of contradictions, the negative and positive view, etc. and is bound to reflect the guidance and restriction of the ancient philosophical thoughts.
Detection of Polyadenylated Subgenomic RNAs in Leaves Infected with the Potexvirus Daphne Virus X (1986)

Summary The genomic RNA (6.0 kb) and five subgenomic RNAs of 4.9, 4.0, 2.1, 1.4 and 0.8 kb were detected by Northern hybridization in leaves of Nicotiana clevelandii infected with daphne virus X (DVX). Also, five species of dsRNA specific to DVX were extracted from infected leaves. In denaturing gels the dsRNAs gave bands with mobilities similar to those of the genomic RNA and the 4.9, 4.0, 2.1 and 0.8 kb subgenomic RNAs. The single-stranded RNAs apparently contain a tract of poly(A) as shown by oligo(dT)-cellulose chromatography and by an increased mobility on agarose gels following digestion with RNase H in the presence of oligo(dT)12–18. When added to reticulocyte lysate, DVX RNA directed the synthesis of a 160000 mol. wt. (160K) protein and several smaller proteins. The coat protein (26K) was identified by immunoprecipitation with antiserum to DVX particles among the translation products of poly(A)-containing RNA isolated from infected leaves. This protein (26K) was translated from the smallest subgenomic RNA (0.8 kb) but was not translated from full-length DVX RNA isolated by centrifugation through formamide-sucrose gradients.
A 173–200 GHz quadrature voltage-controlled oscillator in 130 nm SiGe BiCMOS (2017)

This work presents a fundamental-mode voltage-controlled oscillator (VCO) realized in a 130 nm SiGe BiCMOS process for operation up to 200 GHz. The implemented topology is derived from a feedback phase shifter design, which includes a wideband passive polyphase filter based on 90° and 180° transmission line couplers and a variable-gain active combiner. The fabricated circuit achieves a very large frequency tuning range of 173–200 GHz with a phase noise down to −85 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dBc</sup> /Hz at 10 MHz offset around 188 GHz. As an unique feature this topology allows the simultaneous generation of 90° quadrature signals, which are amplified by an additional single-stage output buffer. The power level of both output signals over a wide bandwidth is −3 dBm each, with a total dc power consumption of 27.7 mW for the oscillator core and 10.3 mW per buffer.
Quantitative assay and disappearance rate of circulating renin (1964)

In isovolemic cross-circulation experiments, a nephrectomized donor rat, into which various doses of hog renin were injected, was connected to a nephrectomized indicator rat. The blood pressure increase thus produced in the indicator rat was compared with the blood pressure response obtained during cross circulation using either intact normotensive or renal hypertensive rats as donor animals. An exponential dose-response relationship was found between hog renin injected into a nephrectomized donor and the blood pressure increase of the indicator rat. Using the cross-circulation technique, the disappearance rate of endogenous reninlike material in the blood of donor animals and of exogenous renin injected into nephrectomized donor animals was examined. If an intact normotensive animal or a unilaterally nephrectomized hypertensive animal is totally nephrectomized, reninlike material disappears from the blood within 1 hr. In renal hypertensive rats with an untouched contralateral kidney which have a higher concentration of reninlike material in the blood, it takes about twice the normal time until reninlike material disappears from the blood after nephrectomy. The increased and prolonged blood pressure response of the nephrectomized animal to renin is not connected with a prolonged persistence of renin in the blood.
Measurement of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>γ</mml:mi><mml:mi>γ</mml:mi><mml:mi>ψ</mml:mi></mml:math>Final States in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi>ψ</mml:mi></mml:mrow><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>Decay (1980)

The decay mode ${\ensuremath{\psi}}^{\ensuremath{'}}\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\gamma}\ensuremath{\psi}$ has been studied with the Mark-II detector at SPEAR. New measurements of branching ratios for decays of the type ${\ensuremath{\psi}}^{\ensuremath{'}}\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\chi}$, $\ensuremath{\chi}\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\psi}$ involving known $\ensuremath{\chi}$ states are presented. The existence of a $\ensuremath{\chi}$ state of mass near 3455 MeV/${\mathit{c}}^{2}$ produced in this decay chain is not confirmed, and the upper limit (90% confidence level) of the product of branching ratios is measured to be 0.13%. A new decay mode, ${\ensuremath{\psi}}^{\ensuremath{'}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{0}\ensuremath{\psi}$, which violates isospin conservation is observed with branching ratio (0.15\ifmmode\pm\else\textpm\fi{}0.06)%.
Detection of magnetic data using a magnetooptic indicator (2002)

We investigate the detection of magnetic data using magnetooptical indicators with in-plane magnetization. A simple model for the magnetooptical detection system is presented. We find that the signal to noise ratio changes strongly with the bit size, the polarization noise, and the distance between the magnetic carrier and the indicator. In particular, it is found that our model a signal to noise ratio of 30 is possible for a bit size of 200 nm. We also estimate the resolution of the system, and find that a spot size of ∼200 nm can be obtained using a suitably designed solid immersion lens. Finally, we discuss detection of several magnetic tracks simultaneously.
Oral Magnetic Particles (1993)

Oral magnetic particles (OMP) have been evaluated in a clinical phase II trial program comprising 216 patients in 7 European centers. Adult patients referred for MR imaging for various abdominal pathologies were examined. the patients received OMP at a concentration of 0.1 g/l (ultralow field) or 0.5 g/l (mid/high field) and OMP was diluted in water or in a more viscous liquid formulation. Depending on the area of interest, OMP was ingested in a volume of 300 to 800 ml. OMP was well tolerated with no serious adverse events and the patient acceptability was good. OMP had a good contrast effect on all applied pulse sequences. the viscous formulation of OMP was homogeneously distributed through the entire gastrointestinal tract without inducing disturbing susceptibility artifacts. the postcontrast diagnostic information was improved in 70% of the cases. Based on the encouraging results in phase II, OMP has been advanced to phase III clinical trials.
Antenna "Inteligente" Construida Mediante Tecnologia de Devanado de Filamentos (1997)

Objectives Fingertip amputation is often encountered in emergency departments, especially in hospitals located near industrial areas. Replantation of the fingertip can be considered when the normal architecture is preserved in cases of sharp amputation. The goal of replantation is to preserve cosmesis and function, especially for the thumb because of its involvement in grasping and the key pinch. Even when microsurgical vascular anastomosis is applied, the absence of venous anastomosis along with the high rate of failure of arterial anastomosis in zone 1A fingertip amputation may lead to replantation failure. Methods We herein present a case report of thumb tip amputation salvaged via a modified cross-finger technique. The recipient site was on the ipsilateral radial side of the intermediate phalanx of the middle finger. Results The thumb tip was successfully replanted with no vascular anastomosis, and this new technique prevented stiffness in the metacarpophalangeal and interphalangeal joints of the thumb and middle finger. Conclusions This procedure can be performed in local clinics and emergency departments without the need for arterial and venous anastomoses.
Non-Newtonian strain relaxation in highly strained SiGe heterostructures (1988)

Semiconductor strained-layer structures routinely incorporate layer stresses in the GPa regime. At these stresses, models for strain relaxation cannot be based on material parameters determined at small stresses. A new analysis of experimental data on strain relaxation in metastable SiGe/Ge(001) strained-layer structures allows the effects of high stresses on relaxation kinetics to be determined. The activation energy for plastic flow is found to decrease roughly linearly with increasing stress, in a manner analogous to non-Newtonian viscous flow in fluids. As a result, macroscopic relaxation occurs more easily and becomes dramatically more abrupt as the growth temperature is reduced than would be extrapolated from the small-stress behavior. Implications for design and fabrication of metastable strained-layer devices are discussed.
Exploring energy and performance behaviors of data-intensive scientific workflows on systems with deep memory hierarchies (2013)

The increasing gap between the rate at which large scale scientific simulations generate data and the corresponding storage speeds and capacities is leading to more complex system architectures with deep memory hierarchies. Advances in non-volatile memory (NVRAM) technology have made it an attractive candidate as intermediate storage in this memory hierarchy to address the latency and performance gap between main memory and disk storage. As a result, it is important to understand and model its energy/performance behavior from an application perspective as well as how it can be effectively used for staging data within an application workflow. In this paper, we target a NVRAM-based deep memory hierarchy and explore its potential for supporting in-situ/in-transit data analytics pipelines that are part of application workflows patterns. Specifically, we model the memory hierarchy and experimentally explore energy/performance behaviors of different data management strategies and data exchange patterns, as well as the tradeoffs associated with data placement, data movement and data processing.