gebhart/patrepeval huggingface dataset:
The potential role of valsartan + AHU377 (LCZ696) in the treatment of heart failure (2013)

LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms. With these promising first results, the results of ongoing further studies in heart failure are eagerly awaited.
Ambulatory ECG (Holter) monitoring in management of acute myocardial ischemia. (1988)

Ambulatory ECG monitoring for detection of transient myocardial ischemia is useful because most ischemic episodes that occur outside the exercise laboratory are not accompanied by symptoms. Special considerations, not required for AEM when used for arrhythmia analysis, must be employed. Although many commercially available recorders provide excellent ST-segment reproduction, some playback systems may have a nonlinear phase response resulting in signal distortion, making ST-segment analysis difficult. Conventional Holter-type AEM devices do not allow for patient or physician intervention during acute myocardial ischemia. Considerable cost and time are required to analyze ST-segment data of prolonged monitoring periods from these tape-recorded signals, and human error and fatigue play an important role in diminishing accuracy of ST-segment interpretation. Automated analysis is done with computer and technician interaction but the accuracy and validation of the various systems for ST-segment analysis from tape recordings requires further detailed study. Newer, real-time ambulatory ECG analyzers are designed for prolonged monitoring periods and directed toward ST-segment analysis. Some devices also alert the patient to an acute ischemic or arrhythmic event allowing for intervention immediately. Some real-time systems have undergone some very encouraging validation studies. These recent studies suggest excellent sensitivity and specificity for detection of ischemic-type ST-segment depression. However, more work is needed before the accuracy of other such devices is known with certainty. As the central goal of therapy for patients with coronary artery disease evolves from simply controlling angina to reduction or elimination of ischemic episodes and their consequences, use of AEM devices will play an increasingly important role in management of these patients.
Novel black silicon PIN photodiodes (2006)

The many advantages of silicon such as low cost, abundancy and a level of maturity that allows for very large scale integration, means that silicon is the most commonly used semiconductor in microelectronics and optoelectronic devices. Silicon, however, has one disadvantage, this being that it is unable to absorb light greater than 1100 nm. The two primary telecommunications wavelengths, 1300 nm and 1550 nm, can therefore not be detected. An interesting method used to extend silicon's wavelength range is the formation of black silicon on the silicon surface. Black silicon is formed when gases that are passed over the silicon react and etch the silicon surface, forming a dark spiky pattern. When light is shone on such a pattern, it repeatedly bounces back and forth between the spikes thus reducing surface reflection and trapping the light. This reduced reflectance and light trapping increases the sensitivity of the silicon to long wavelengths and makes it viable for use in a wide range of commercial devices such as infrared detectors and solar cells. This paper presents novel black silicon PIN photodiodes of various sizes (25 mm<sup>2</sup>, 4 mm<sup>2</sup> and 1 mm<sup>2</sup>). The diodes have been extensively characterized at wafer level, with breakdown voltage, dark current, shunt resistance, threshold voltage and junction capacitance measurements being made. Extensive responsivity measurements were also performed and it was established that the black silicon surface resulted in responsivity increases of greater than 50 % at long wavelengths (≈ 1100 nm).
Magnetic properties of amorphous Gd-Fe films prepared by evaporation (1976)

Amorphous GdxFe1−x films with 0.18&lt;x&lt;0.33 were prepared by electron-beam coevaporation of the elements. The composition dependence of anisotropy and the composition and temperature dependence of saturation magnetization of the films were studied. In contrast to evaporated Gd-Co films, where anisotropy is in-plane, the Gd-Fe films were found to have strong perpendicular anisotropy with the uniaxial anisotropy constant (Ku) decreasing monotonically from 3.8×105 erg/cm3 at x=0.18 to 2.0×105 erg/cm3 at x=0.33. The perpendicular anisotropy field (HK) reached a maximum at the compensation composition (x=0.26) and fell off rapidly on both sides. The findings suggest that anisotropy in evaporated films is due to a longer-range structural ordering than the pair ordering which is assumed to exist in sputtered films. Saturation magnetization measurements showed that magnetization of the amorphous alloys could be closely approximated from the moments of pure crystalline Gd and Fe. The 0 °K moment of Fe was found to be 2.20μB (0.23&lt;x&lt;0.31) suggesting less charge transfer than in crystalline GdFe3. Q values (HK/4πMs) of the alloys exceeded unity in the range 0.19&lt;x&lt;0.31.
The Fibronectin Domains of the Neural Adhesion Molecule TAX-1 Are Necessary and Sufficient for Homophilic Binding (1996)

Cell adhesion molecules belonging to the immunoglobulin superfamily promote cell aggregation and neurite outgrowth. These proteins are multidomain molecules comprising a number of distinct modules, notably Ig domains of the C2 class and fibronectin type III repeats. A subgroup of these neural adhesion molecules are linked to the membrane with a glycosylphosphatidylinositol anchor and show a more restricted pattern of expression in the embryo. Among them, the human homologue of the transient axonal glycoprotein, named TAX-1, shares a great degree of similarity at the protein level with rodent TAG-1. In the present study we set out to determine which domains of TAX-1 are involved in promoting the homophilic, adhesive properties of the molecule. We established stable Schneider-2 cell lines expressing the intact molecule, the fibronectin, or the immunoglobulin domains. The fibronectin domains were necessary and sufficient to mediate homophilic binding and induce cell aggregation, a response also observed with cells expressing the intact TAX-1 molecule. Aggregation was inhibited by the secreted form of the TAG-1 protein. On the other hand, the immunoglobulin domains by themselves were not able to induce cell aggregation. In addition, TAX-1 was localized in areas of cell contact among aggregating cells, justifying its role as an adhesion molecule.
Meaningful Multicollinearity Measures (1978)

Problems of multicollinearity in regression analysis are considered and numerical measures established to assess the extent of multicollinearity in a set of regression data with respect to parameter confidence regions and tests of hypotheses, the effective sample size, and predictability.
CloudTUI-FTS: a user-friendly and powerful tool to manage Cloud Computing Platforms (2016)

The NIST defines Cloud Computing as a model for en-abling ubiquitous network access to a shared pool of con-figurable computing resources. Thanks to the popularity of Cloud Computing and its various area of applicability, in the last years various projects have been realized for building Cloud syste
Studies in massively speaker-specific speech recognition (2004)

Over the past several years, the primary focus for the speech-recognition research community has been speaker-independent speech recognition, with the emphasis of working on databases with larger and larger numbers of speakers. For example, the most recent EARS program, which is sponsored by DARPA, calls for recordings of thousands of speakers. However, we are interested in making a speech interface work well for one particular individual, and we propose using massive amounts of speaker-specific training data recorded in daily life. We call this massively speaker-specific recognition (MSSR). As a pre-research, we leverage the large corpus we have available from speech-synthesis work to study the benefit of MSSR only from the acoustic-modeling aspect. Initial results show that, by changing the focus to MSSR, word error rates can drop very significantly. In comparison with speaker-adaptive speech recognition systems, MSSR also performs better since model parameters can be tuned to be suitable to one particular individual.
Elevated Alt and Ast in an Asymptomatic Person: What the primary care doctor should do? (2009)

Abnormal liver function test with raised alanine aminotransferase (ALT) and raised aspartate aminotransferase (AST) are commonly seen in primary care setting.Chronic alcohol consumption, drugs, non-alcoholic steatohepatitis (NASH) and chronic viral hepatitis are common causes associated with raised ALT and AST.In chronic viral hepatitis, the elevation of liver enzyme may not correlate well with the degree of liver damage.Non-hepatic causes of raised ALT and AST include polymyositis, acute muscles injury, acute myocardial infarction and hypothyroidism.In the primary care setting, the doctor should obtain a complete history regarding the risk factors for viral hepatitis, substance abuse and request investigations accordingly.Suspected chronic viral hepatitis and liver cirrhosis are best referred to hepatologist for further management.
Carrier Displacement Chromatography on Ion Exchange Resins (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarrier Displacement Chromatography on Ion Exchange ResinsDonald L. BuchananDonald L. BuchananMore by Donald L. BuchananCite this: Anal. Chem. 1959, 31, 5, 833–836Publication Date (Print):May 1, 1959Publication History Published online1 May 2002Published inissue 1 May 1959https://pubs.acs.org/doi/10.1021/ac60149a030https://doi.org/10.1021/ac60149a030research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Yet Another Paradigm! (2001)

The consensus view in the profession is that security is a people problem, not a technical one. Lots of people have articulated this, particularly Bruce Schneier in his recent testimony to the US Congress. I, myself, state this “fact” regularly in presentations and lectures as my “Second Law of Computer Security” (subordinate only to “Security must be appropriate for the particular business requirement”). Recent experience in conducting a security audit in a major multinational utilities company, has lead me to reconsider whether this is the key message to get across to systems designers, purchasers and operators.
Clock skew optimization for maximizing time margin by utilizing flexible flip-flop timing (2015)

Clock skew scheduling is one of the essential steps to be carefully performed during the design process. Two commonly used strategies for solving the task are the scheduling of clock arrival times under bounded clock skew constraint and the scheduling of clock arrival times under hold and setup time constraints. This work belongs to the useful clock skew scheduling. In comparison with the prior works in which the inter-dependent relation between the setup and hold times of flip-flops have never been exploited, this work addresses the clock skew optimization problem integrated with the consideration of the interdependent relation between the setup and hold times, and clock-to-Q delay of flip-flops, so that the time margin is more accurately and reliably set aside over that of the previous methods, which have never taken the integrated problem into account. Precisely, based on an accurate flexible model of setup time, hold time, and clock-to-Q delay, we propose a stepwise clock skew scheduling algorithm in which at each iteration, the worst slack of setup and hold times is systematically and incrementally relaxed to maximally extend the time margin. The effectiveness of the proposed method is shown through experiments with benchmark circuits, demonstrating that our method relaxes the worst slack of circuits, so that the clock period (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">clk</sub> ) is shortened by 4.2% on average, namely the clock speed is improved from 369MHz~2.23GHz to 385MHz~2.33GHz with no time violation. In addition, it reduces the total numbers of setup and hold time violations by 27.7%, 9.5%, and 6.7% when the clock periods are set to 95%, 90%, and 85% of the value of T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">clk</sub> , respectively.
GLUTAMINE—A MAJOR SUBSTRATE FOR NERVE ENDINGS (1978)

Abstract— Mammalian cortical synaptosomes incubated in the presence of glucose (2.5 MM) plus glutamine (0.5 mM) showed a 30% increase in transmitter amino acid content over controls with glucose alone and a doubling of glutamate release induced by Veratrine or high K + . Double‐label experiments, i.e. [U‐ 14 C]glucose with [ 3 H]glutamine, and single‐label experiments, i.e. [U‐ 14 C]glucose or [U‐ 14 C]‐glutamine showed that stimulus‐released glutamate was derived principally (80%) from glutamine. Released glutamine‐derived glutamate was of higher (x 2) specific radioactivity than its tissue equivalent. Glutamine alone (0.5–0.75 mM) was much less effective than equivalent amounts of glucose alone, in stimulating respiration and maintaining tissue K + levels.
Analysis and implementation of an adjustable-rate multilevel coded modulation system (1997)

The authors describe the design of a multilevel coded modulation system. The main goal is to achieve a high degree of rate flexibility, with the same hardware allowing for the implementation of several coded schemes. This is obtained by associating a hierarchy of punctured convolutional codes with the partition chain of a square-lattice signal constellation. After discussing the rationale behind their design choices and implementation details, the authors analyse the system by computing its error probabilities, and show experimental results.
Morphological differences between subitaneous and diapause eggs of <i>Boeckella triarticulata</i> (Copepoda: Calanoida) (2001)

1. Many calanoid copepods produce subitaneous eggs that hatch immediately and diapause eggs that remain dormant for long periods of time. Boeckella triarticulata (Copepoda: Calanoida) produces diapause eggs that hatch asynchronously over an extended period of time and appear identical under light microscopy to those that hatch immediately. 2. We compared the internal morphology of subitaneous and diapause eggs of B. triarticulata that had been prepared for transmission electron microscopy by four methods. 3. Subitaneous eggs had a thin, single‐layered shell whereas diapause eggs had a thick, three‐layered shell that appeared consistent over 3 months of diapause. Boeckella triarticulata appears to enter diapause at the multicellular stage. 4. Consistent morphological differences between subitaneous and diapause eggs of B. triarticulata suggest that these two egg types also have distinct differences in physiology, and are not merely extremes of a continuum from subitaneous to diapause eggs.
Dose-dependent effects of gonadotropin on oocyte developmental competence and apoptosis (2011)

The aim of the present study was to evaluate the effect of gonadotropins (Gn) on oocyte maturation, developmental competence and apoptosis in an animal model. Bovine cumulus-oocyte complexes (COCs) were matured for 24 h in media supplemented with varying concentrations of Bravelle (B), B + Menopur (B+M) or B + Repronex (B + R) (Ferring Pharmaceuticals, Parsiappany, NJ, USA). Then, nuclear maturation, embryo development, and apoptosis in cumulus cells and oocytes were evaluated. Low to moderate Gn concentrations (75-75 00 mIUmL(-1)) effectively improved nuclear maturation and in vitro development. Higher concentrations of Gn (75 000 mIUmL(-1)) did not have any added beneficial effects and nuclear maturation and blastocyst rates in the presence of these concentrations were comparable to control (P>0.05). Most COCs showed slight apoptosis when exposed to 75, 750 and 75 00 mIUmL(-1) Gn; however, when the concentration was increased to 75 000 mIUmL(-1), the proportion of moderately apoptotic COCs increased. In conclusion, extremely high concentrations of Gn have detrimental effects on oocyte nuclear maturation and embryo development and increase apoptosis in cumulus cells, suggesting the importance of judicious use of Gn in assisted reproductive technologies (ART).
A note on intimations of "post-modernism" in "manon lescaut" (2000)

The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth of<i>Escherichia coli</i>and<i>Staphylococcus aureus</i>for 4-6 orders of magnitude. Therefore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones.
La pyrolyse de poly(adipate de butylène-1,4) (1977)

Poly(1,4-butylene adipate) (1) was pyrolyzed in a porcelain boat placed in a quartz tube heated by a furnace. Volatile products were carried out of the heated zone into traps by a flow of nitrogen. Polyester 1 was pyrolyzed both near the entrance and near the exit of the heated zone, at 500 and 700 °C with and without a vacuum. Adipic acid (2), cyclopentanone (4), and a mixture of mono (5) and diesters (6) of the monomer, dimer, and trimer, were isolated as products of the pyrolyses.The pyrolyses of 1 at 500 °C near the exit of the heated zone at atmospheric pressure gave 14% of 2, 10% of 4, 40% of 5, and 18% of 6; 5 consisted of 26% monoester of monomer and 74% monoester of dimer, whereas 6 consisted of 63% diester of monomer and 37% diester of dimer. At 700 °C, 0.2–0.3 Torr, with 1 near the entrance of the heated zone, the yield of 2 was higher (∼35%), and trimers were found in the monoesters 5 and diesters 6, along with dimers and monomers.
Bridgehead N heterocycles. I. Convenient synthesis of pyrazolo[1,5-a]pyridines (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBridgehead N heterocycles. I. Convenient synthesis of pyrazolo[1,5-a]pyridinesK. T. Potts, U. P. Singh, and J. BhattacharyyaCite this: J. Org. Chem. 1968, 33, 10, 3766–3770Publication Date (Print):October 1, 1968Publication History Published online1 May 2002Published inissue 1 October 1968https://doi.org/10.1021/jo01274a018RIGHTS & PERMISSIONSArticle Views237Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (716 KB) Get e-Alerts Get e-Alerts