gebhart/patrepeval huggingface dataset:
Using Ultrasonic Spectrometry to Estimate the Stability of a Dental Implant Phantom (2012)

A challenging problem in dental implant surgery is to evaluate the stability of the implant. In this simulation study, an experimental phantom is used to represent a jawbone with a dental implant. It is made of a little pool filled with soft-tissue equivalent material and a disc of fresh Oakwood with a metal screw. Varying levels of contact between screw and wood are simulated by screwing in or out the screw. Initially, the screw is screwed in and fixed firmly in wood. Thereafter, the screw is screwed out, a half turn each time, to increase the gap gradually between wood and screw. Pulse-echo ultrasound is used and the power spectra of the received echo-signals are computed. These spectra are normalized then analyzed by using the partial least squares method to estimate the corresponding implant stiffness grade in terms of number of turns when beginning from the initial tight-screw state then screwing out the screw. A coefficient of determination R 2 of 96.4% and a mean absolute error of ±0.23 turns are achieved when comparing real
Conductor-polymer composite electrode materials (1984)

A conductive composite material useful as an electrode, comprises a conductor and an organic polymer which is reversibly electrochemically dopable to change its electrical conductivity. Said polymer continuously surrounds the conductor in intimate electrical contact therewith and is prepared by electrochemical growth on said conductor or by reaction of its corresponding monomer(s) on said conductor which has been pre-impregnated or pre-coated with an activator for said polymerization. Amount of the conductor is sufficient to render the resultant composite electrically conductive even when the polymer is in an undoped insulating state.
Impedance control for multi-point human-robot interaction (2011)

ASCC 2011 - 8th Asian Control Conference - Final Program and Proceedings
Abstract CT017: Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients (2018)

Abstract BACKGROUND: Combination immunotherapy has the potential to achieve additive or synergistic effects. Combined local injections of dsRNA analogues (mimicking viral RNA) and repeated vaccinations with tumor-lysate loaded dendritic cells shows efficacy against colon cancer mouse models. In the context of immunotherapy, radiotherapy can exert beneficial abscopal effects on distant non-irradiated lesions. PATIENTS AND METHODS: In this pilot phase I study, 15 advanced cancer patients received two 4-week cycles of four intradermal daily doses of monocyte-derived dendritic cells preloaded with autologous tumor lysate and matured for 24h with poly-ICLC (Hiltonol), TNF-α and IFN-α. On days +8 and +10 of each cycle, patients received intratumoral image-guided 0.25 mg injections of the dsRNA-analogue Hiltonol. Cyclophosphamide 600 mg/m2 was administered one week before each cycle. Six patients received stereotactic ablative radiotherapy (SABR) on selected tumor lesions, including those injected with Hiltonol. Expression of 25 immune-relevant genes was sequentially monitored by RT-PCR on circulating PBMCs and serum concentrations of a cytokine panel were sequentially determined before and during treatment. RESULTS: Combined treatment was feasible, safe and well tolerated, without grade 3-4 adverse events. One heavily pretreated castration-resistant prostate cancer patient experienced a remarkable mixed abscopal response to SABR and combined treatment. No objective responses were observed, while nine patients (Disease control rate=71%) presented stable disease (five in the six-patient radiotherapy cohort). Intratumoral Hiltonol increased IFN-β and IFN-α mRNA in circulating PBMC. Dendritic-cell vaccination increased serum IL-12 and IL-1β concentrations, especially in patients presenting stable disease. CONCLUSIONS: This radio-immunotherapy combination strategy, aimed at resembling viral infection in tumor tissue in combination with a dendritic-cell vaccine and SABR, is safe and provides evidence of immune-associated activity and signs of preliminary clinical efficacy. Citation Format: Maria E. Rodriguez-Ruiz, Jose L. Perez-Gracia, Inmaculada Rodriguez, Carlos Alfaro, Ignacio Gil-Bazo, Alfonso Gurpide, Andres Salazar, Ignacio Melero. Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr CT017.
Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein (2004)

The biphasic waveform that can predict for disseminated intravascular coagulation (DIC) is due to the formation of a calcium-dependent complex between C reactive protein (CRP) and very low density lipoprotein (VLDL). As thrombin generation is pivotal to DIC, this aspect has been specifically investigated and the VLDL component has been found to increase prothrombinase activity via both quantitative and qualitative changes. The specific prothrombinase activity of VLDL from patients manifesting the biphasic waveform was 2.5 times that of normal individuals or critically ill patients without the biphasic waveform. This activity was due to an increase in anionic phospholipid surfaces that could be inhibited with excess annexin V and which was dependent on structurally intact apolipoprotein B. The qualitative change appeared to be due to a deficiency of phosphatidylethanolamine in VLDL from patients with the biphasic waveform. The functional consequence of this enhanced prothrombinase activity was an increased procoagulant effect in plasma. Using a modified activated partial thromboplastin time assay, the mean normal clot time decreased significantly when VLDL from patients with biphasic waveforms was substituted. These results indicate that VLDL derived from patients with the biphasic waveform can enhance thrombin procoagulant activity. As the CRP-VLDL complex exists in vivo, it could have a pathogenic role in disseminating the process of intravascular coagulation.
Insensitivity of the chick embryo Müllerian duct to human recombinant Müllerian-inhibiting substance (1992)

To determine whether mammalian Müllerian-inhibiting substance (MIS) is active in birds, Müllerian ducts from 7- to 8-day-old male or female chick embryos were cultured in the presence of human recombinant MIS at concentrations between 2.5 and 12.5 micrograms/ml. None of 20 ducts regressed at any concentration. In contrast, at concentrations of 2.5-5 micrograms/ml, all 12 Müllerian ducts from 13-day-old male mouse embryos and 13 out of 14 female ducts were inhibited to varying degrees. It is concluded that avian Müllerian ducts are unresponsive to mammalian MIS. There may be a difference in structure between the MIS of birds and mammals, or the signal-transduction system may be different.
Earthquake response analysis of reinforced-soil walls using FLAC (2020)

The paper summarizes recent work by the writers that is focussed on the use of program FLAC to model the dynamic response of reinforced-soil retaining walls under base excitation. The simulated plane strain model walls were propped-panel type reinforced by horizontal layers of sheet materials with stiffness values in the range expected for relatively extensible polymeric materials (geosynthetics) to steel products. Some results of parametric studies are reported here including the influence of reinforcement stiffness, reinforcement length and toe restraint. Modeling parameters investigated included the location and type of far-end boundary condition and damping ratio. The work described in this paper is the first reported use of FLAC in the open literature to investigate seismic response analysis of retaining walls constructed with extensible reinforcement materials (geosynthetics).
ChemInform Abstract: 1‐METHYL‐2‐(2‐HYDROXYPHENYL)IMIDAZOLE: A CATALYTIC PHOSPHATE PROTECTING GROUP IN DEOXYOLIGONUCLEOTIDE SYNTHESIS (1985)

Abstract Die mit dem Titelreagens (III) eingeführte Hpmi‐Schutzgruppe [‐ (IVa)] ermöglicht gegenüber der üblichen p‐Chlorphenyl‐ Schutzgruppe [‐ (IVb)] eine wesentlich schnellere Knüpfung der Internucleotid‐ Bindung (vermutlicher Reaktionsverlauf über ein aktives cyclisches Intermediä‐ res).
Crystallization of an Ordered Mesoporous Nb–Ta Oxide (2003)

Durch Ausfüllen der Poren in der Kristallisations-Vorstufe mit Kohlenstoff bleibt die zweidimensionale hexagonale Ordnung von gemischtem Niob-Tantal-Oxid erhalten. Beim Erhitzen unter Inertgas kristallisiert das Produkt, ohne dass die mesoporöse Struktur verlorengeht. Das Kohlenstoff-Templat kann durch Calcinierung an der Luft entfernt werden. Elektronenmikroskopie und Elektronenbeugungsanalyse belegen die geordnete mesoporöse Struktur der ca. 100 nm großen einkristallinen Bereiche.
Perceptual entropy rate estimates for the phonemes of American English (2002)

We estimated the perceptual entropy rate of the phonemes of American English and found that the upper limit of the perceptual entropy of voiced phonemes is approximately 1.4 bit/sample, whereas the perceptual entropy of unvoiced phonemes is approximately 0.9 bit/sample. Results indicate that a simple voiced/unvoiced classification is suboptimal when trying to minimize bit rate. We used two different methods for the entropy estimation, and the results of both methods show that short segments of unvoiced speech are approximately Gaussian.
Gyrotron-powered millimeter-wave beam facility for microwave processing of materials (2003)

Summary form only given, as follows. The high intensity millimeter-wave beams (10/sup 3/-10/sup 5/ W/cm/sup 2/) that can be generated by powerful gyrotron oscillators have unique capabilities for rapid, selective heating of nonmetallic materials. A new CW gyrotron-based system is being set up at the Naval Research Laboratory (NRL) to investigate such beams. The facility is being operated jointly by NRL and the Center for Remote Sensing (CRS) and will be applied to important areas of material processing including: coating of materials, soldering and brazing, and treatment of ceramics and polymers. The heart of the system is a Gycom, Ltd. industrial 83 GHz gyrotron operating at 27 kV and 1.9 A, and producing 15 kW of power in a Gaussian beam. This paper will describe the new facility, including the gyrotron, work chamber, and control system. Available results of initial beam characterization and material heating experiments will also be presented.
Calibration of the modulation transfer function of surface profilometers with binary pseudo-random test standards: expanding the application range (2010)

A modulation transfer function (MTF) calibration method based on binary pseudo-random (BPR) gratings and arrays [Proc. SPIE 7077-7 (2007), Opt. Eng. 47(7), 073602-1-5 (2008)] has been proven to be an effective MTF calibration method for a number of interferometric microscopes and a scatterometer [Nucl. Instr. and Meth. A 616, 172-82 (2010]. Here we report on a significant expansion of the application range of the method. We describe the MTF calibration of a 6 inch phase shifting Fizeau interferometer. Beyond providing a direct measurement of the interferometer's MTF, tests with a BPR array surface have revealed an asymmetry in the instrument's data processing algorithm that fundamentally limits its bandwidth. Moreover, the tests have illustrated the effects of the instrument's detrending and filtering procedures on power spectral density measurements. The details of the development of a BPR test sample suitable for calibration of scanning and transmission electron microscopes are also presented. Such a test sample is realized as a multilayer structure with the layer thicknesses of two materials corresponding to BPR sequence. The investigations confirm the universal character of the method that makes it applicable to a large variety of metrology instrumentation with spatial wavelength bandwidths from a few nanometers to hundreds of millimeters.
Investigation on reversed domain structures in lithium niobate crystals patterned by interference lithography (2003)

We demonstrate fabrication of periodically poled lithium niobate samples by electric field poling, after patterning by interference lithography. Furthermore we investigate the poling process at an overpoling regime which caused the appearance of submicron dot domains very similar to those induced by backswitch but different in nature. We show the possibility for realizing submicron-scaled threedimensional domain patterns that could be applied to the construction of photonic crystals and in nonlinear optics. We show that high etch-rate applied to such structures allows to obtain pyramidal-like submicron relief structures which in principle could find application for waveguide construction in photonic bandgap devices.
A 1MA, variable risetime pulse generator for high energy density plasma research (2008)

COBRA is a 0.5 Omega pulse generator driving loads of order 10 nH inductance to >1 MA current. The design is based on independently timed, laser-triggered switching of four water pulse-forming lines whose outputs are added in parallel to drive the load current pulse. The detailed design and operation of the switching to give a wide variety of current pulse shapes and rise times from 95 to 230 ns is described. The design and operation of a simple inductive load voltage monitor are described which allows good accounting of load impedance and energy dissipation. A method of eliminating gas bubbles on the underside of nearly horizontal insulator surfaces in water was required for reliable operation of COBRA; a novel and effective solution to this problem is described.
Effective properties of amorphous metamaterials (2009)

We experimentally and numerically study the propagation of light through amorphous metamaterials. For this purpose we introduce a precisely controllable degree of positional disorder into a perfectly periodic system, transforming it to a partially disordered and ultimately an amorphous metamaterial. The observable spectral features occurring upon this transition and the impact of coherent interactions among neighboring unit cells are revealed. Backed by numerical simulations, the effective properties of the metamaterials are retrieved, most notably for the amorphous one. The most important finding with respect to negative index materials is that their magnetic properties are not affected by an arbitrarily high degree of disorder. This work enables the quantitative evaluation of effective properties of amorphous metamaterials fabricated by bottom-up approaches.
Elispot and Elisa Assessment of Interferon-Gamma after Sublingual Immunotherapy (2010)

Allergic rhinitis (AR) is characterized by a Th2 polarized immune response, and specific immunotherapy modifies this arrangement, restoring a physiologic Th1 profile. Sublingual immunotherapy (SLIT) is widely prescribed. The aim of the study is to evaluate two different methods for assessing IFN-γ, namely ELISPOT and ELISA, before and after a pre-seasonal SLIT course as marker for Th1 response. Thirty-eight AR patients with pollen allergy assumed pre-seasonal SLIT for 3 months. Patients' blood samples for assessing IFN-γ serum levels were collected before initiating SLIT (baseline – T0), after 3 months pre-seasonal SLIT course (T1), and three months after completion of SLIT (T2). IFN-γ-specific producing cells, after allergen stimulation, were assessed by cytokine ELISPOT at the same time points. IFN-γ-specific producing cells significantly increased after SLIT both at T1 and T2 (p=0.0002). On the contrary, ELISA assessment did not reveal an increase in IFN-γ serum levels at any time point. In conclusion, these results demonstrate that ELISA assessment of serum IFN-γ is not suitable for identifying an early response.
Notes: Rearrangement of 9α-Hydroxy-4-androstene-3,17-dione (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes: Rearrangement of 9α-Hydroxy-4-androstene-3,17-dioneLeland Chinn and R DodsonCite this: J. Org. Chem. 1959, 24, 6, 879Publication Date (Print):June 1, 1959Publication History Published online10 July 2003Published inissue 1 June 1959https://pubs.acs.org/doi/10.1021/jo01088a622https://doi.org/10.1021/jo01088a622research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fast atom bombardment mass spectra of involatile monophosphonated and mixed sulphonated/monophosphonated azo dyestuffs (1983)

Abstract Fast atom bombardment mass spectra of a range of involatile monophosphonated and mixed sulphonated/monophosphonated azo dyestuffs are presented. Good spectra are obtained and the fragmentations are discussed with special reference to the ions formed by cleavage of the azo linkage. The negative ion spectra are shown to be superior in terms of signal to background and structural information to those obtained in the positive ion mode. The results are compared with those obtained from sulphonated azo dyestuffs.
A new nomogram to predict pathologic outcome following radical prostatectomy (2006)

Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer.
Erratum: “Electrochemical hydrogen storage of Ti–V-based body-centered-cubic phase alloy surface-modified with AB5 nanoparticles” [Appl. Phys. Lett. 87, 133121 (2005)] (2005)

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SIMULATION OF GENETIC INTERACTION FOR <i>DROSOPHILA</i> LEG FORMATION (1998)

The formation of Drosophila wings and legs are major research topics in Drosophila development, and several hypotheses, such as the polar-coordinate model and the boundary model, has been proposed to explain mechanisms behind these phenomena. A series of recent studies have revealed complex interaction among genes involved in establishing three principal axes (A-P, D-V, and P-D) of leg formation. In this paper, we present a simulation system for leg formation, simulating the genes interactions involved. We use this simulator to investigate a mathematical framework of leg formation which is otherwise well-founded from a molecular perspective. Particularly, we focus on the formation of the expression patterns of dpp, wg, dll, dac, al, en, hh and ci genes, which are involved in the development of the third instar Drosophila leg disc. The most interesting part of this research is showing how the coaxial gene expression patterns behind the P-D axis can be formed, and how positional information, as postulated in the polar-coordinate model, can be conveyed to each cell. Our results suggest that P-D axis can be formed by a set of genes with different activation thresholds; the process involves different chemical gradients of dpp and wg products, forming a bi-polar contour. Interestingly, this combination of chemical gradients can specify unique positions of cells for the hemisphere, leaving the A-P axis determiner to decide only whether the cells are anterior or posterior. All in all, our so-called Bi-Polar Model describes axial formation of the leg disc well.
Ligand Recognition in the Opioid Receptors by Modeling Methods and the Design of Opioids (1998)

For understanding the three-dimensional mechanisms that control potency and selectivity of the ligand binding at the atomic level, we have analysed opioid receptor-ligand interaction based on the receptor's 3D model. The analyses of the interactions of some opioid ligands with the predicted ligand binding sites are consistent with the results of the affinity labeling experiments. On the basis of the three-dimensional structures of the putative binding sites in the opioid receptors, a potent kappa agonist KT-95 was designed in our laboratory.
An Integrated Specification of Values, Objects and Processes for Object-Oriented Models (Extended Abstract) (1990)

The goal of the research summarized in this abstract is first, to formalize object-oriented models and second, to develop a method for producing these models. This goal can be stated in semi-formal form as the solution of the following equations for the unknown terms that appear on the right-hand side of an equation, but do not appear at a left-hand side. (1) method = specification language + semantics + pragmatics (2) pragmatics = tasks + task ordering + heuristics By ‘‘method’’ we mean a method to develop a conceptual model (CM) of a universe of discourse (UoD). The specification language should be formal, and each consistent specification has an intended denotational model which can serve as a CM of a UoD. The semantics should include a significant portion of the structures that are found in the "semantic data models" studied in the past and in object-oriented models currently being developed. The pragmatics give advice on how to go about finding the relevant structures in the UoD and specify a model of them in the specification language. This is basically a set of tasks to be executed by the analyst/designer. Often, there should also be an advice on the ordering of tasks as well as a set of heuristics that help the analyst make decisions during the modeling process.
Material processing metallurgy and thermoelectric characterization and their correlations of Bi2Te3 compound. (2011)

Abstract not provided.
Structure-Activity Relationship Modeling for Predicting Interactions with Pregnane X Receptor by Recursive Partitioning (2012)

Pregnane X receptor (PXR) is a ligand-activated nuclear factor that upregulates the expression of proteins involved in the detoxification and clearance of xenobiotics, primarily cytochrome P450 3A4 (CYP3A4). Structure-activity relationship (SAR) analysis of PXR agonists is useful for avoiding unwanted pharmacokinetics due to drug-drug interactions. To perform large-scale ligand-based SAR modeling, we systematically collected information on chemical-PXR interactions from the PubMed database by using the text mining system we developed, and merged it with screening data registered in the PubChem BioAssay database and other published data. Curation of the data resulted in 270 human PXR agonists and 248 non-agonists. After the entire data set was divided into training and testing data sets, the training data set comprising 415 data entries (217 positive and 198 negative instances) was analyzed by a recursive partitioning method. The classification tree optimized by a cross-validation pruning algorithm gave an accuracy of 79.0%, and, for the external testing data set, could correctly classify PXR agonists and non-agonists at an accuracy of 70.9%. Descriptors chosen as splitting rules in the classification tree were generally associated with electronic properties of molecules, suggesting they had an important role in the modes of interaction.