gebhart/patrepeval huggingface dataset:
Caregiving, residence, race, and depressive symptoms (2010)

The objective of this study is to evaluate the psychological responses to caregiving between black and white dementia caregivers measured by self-reports of depressive symptoms evaluating the impact of sub-components of the Center for Epidemiologic Studies Depression Scale (CES-D) and residential arrangements of the caregiving dyad. The method included 87 intergenerational family caregivers enrolled in the Duke Caregiver Study (50 white and 37 black). Total CES-D and the four sub-components were modeled as dependent measures in separate linear regressions. Three models were examined. The first model tested race, living arrangements, and their interaction. The second model adjusted for age, gender, education, income, health status, cultural justification for caregiving, crime concerns, systolic blood pressure, diastolic blood pressure, and glycosylated hemoglobin. A third model added adjustment for caregiver burden. The results showed that there was a significant race by residence interaction for CES-D, somatic symptoms and depressive affect such that when the dyads are living apart-with the care recipient in their own home or in an institutional setting-whites reported more depressive symptoms than blacks. When the dyads lived together, this was reversed, and blacks reported higher depressive symptoms than whites. To conclude, all the parameters such as race, living arrangements, and the components of depression need to be taken into account to understand the impact of caregiving on the emotional health of caregivers.
The antifungal plant defensin Ah<scp>PDF</scp>1.1b is a beneficial factor involved in adaptive response to zinc overload when it is expressed in yeast cells (2015)

Antimicrobial peptides represent an expanding family of peptides involved in innate immunity of many living organisms. They show an amazing diversity in their sequence, structure, and mechanism of action. Among them, plant defensins are renowned for their antifungal activity but various side activities have also been described. Usually, a new biological role is reported along with the discovery of a new defensin and it is thus not clear if this multifunctionality exists at the family level or at the peptide level. We previously showed that the plant defensin AhPDF1.1b exhibits an unexpected role by conferring zinc tolerance to yeast and plant cells. In this paper, we further explored this activity using different yeast genetic backgrounds: especially the zrc1 mutant and an UPRE-GFP reporter yeast strain. We showed that AhPDF1.1b interferes with adaptive cell response in the endoplasmic reticulum to confer cellular zinc tolerance. We thus highlighted that, depending on its cellular localization, AhPDF1.1b exerts quite separate activities: when it is applied exogenously, it is a toxin against fungal and also root cells, but when it is expressed in yeast cells, it is a peptide that modulates the cellular adaptive response to zinc overload.
Modulation of Coordination Chemistry in Copper(I) Complexes Supported by Bis[2-(2-pyridyl)ethyl]amine-Based Tridentate Ligands (2001)

Structure and physicochemical properties of copper(I) complexes of the tridentate ligands L(2) (N,N-bis[2-(6-methylpyridin-2-yl)ethyl]phenethylamine) and L(3) (N,N-bis[2-(2-pyridyl)ethyl]-beta-methylphenethylamine) have been examined to obtain deeper insights into modulation of the coordination chemistry of copper(I) complexes. [Cu(I)(L(2))(CH(3)CN)](ClO(4)) (2.CH(3)CN) has a distorted tetrahedral geometry, which consists of three nitrogen atoms of the ligand and one nitrogen atom of the bound CH(3)CN. Steric repulsion between the 6-methyl group on the pyridine nucleus of L(2) and the metal ion of the complex prevents the cuprous complex from adaptation to a three-coordinate geometry which must have a shorter Cu-N(pyridine) distance ( approximately 1.88 A). Thus, the four-coordinate copper(I) complex (2.CH(3)CN) with a longer Cu-N bond (1.98 approximately 2.13 A) becomes favorable, resulting in rather strong binding of CH(3)CN to the metal ion. In [Cu(I)(L(3))](ClO(4)) (3), there is a Cu(I)-pi interaction between the cuprous ion and the phenyl group of the ligand sidearm. Such a copper(I)-arene interaction is essentially weak, but is significantly stabilized in complex 3. The methyl group at the benzylic position of L(3)() reduces the degree of freedom of sidearm rotation to make the phenyl group stick on the cuprous ion. Thus, the reactivity of the copper(I) complexes of L(2) and L(3) toward dioxygen is significantly diminished, showing sharp contrast to the high reactivity of the copper(I) complex supported by a similar tridentate ligand L(1) (N,N-bis[2-(2-pyridiyl)ethyl]phenethylamine).
Stereospecific syntheses of epimeric diterpenoid. Resin acids through enolate anion reactions (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific syntheses of epimeric diterpenoid. Resin acids through enolate anion reactionsMartin E. Kuehne and James A. NelsonCite this: J. Org. Chem. 1970, 35, 1, 161–170Publication Date (Print):January 1, 1970Publication History Published online1 May 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/jo00826a036https://doi.org/10.1021/jo00826a036research-articleACS PublicationsRequest reuse permissionsArticle Views432Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase II study of vinorelbine (VRL) alternating i.v. and oral in combination with docetaxel (DTX) as 1<sup>st</sup> line chemotherapy (CT) of metastatic breast cancer (MBC) (2005)

783 Background: VRL and DTX are targeting tubulin-microtubule system, either inhibiting tubulin polymerisation (VRL) or microtubule depolymerisation (DTX). Both agents have proven activity in MBC. Methods: This study was designed to evaluate the efficacy and the tolerance of the combination of i.v. VRL 20 mg/m2 with DTX 60 mg/m2 on day 1 and oral VRL 60 mg/m2 on day 15 of a three-week cycle in first line treatment MBC for a maximum of 6 cycles. Prior adjuvant CT was allowed if completed at least 12 months before study entry. At least one bidimensionally measurable lesion (WHO criteria) should be present. Results on the first 23 treated patients are as follows: median age was 56(y), 16 pts (69.6%) had received prior adjuvant chemotherapy, 22 pts (95.7%) had a KPS ≥80%, and 10 pts (43.5%) had ≥3 sites involved. All patients were eligible and evaluable for efficacy. A total of 129 cycles were given (median 6). Median relative dose intensities (RDI) of i.v.VRL and DTX were over 99% and median RDI of oral VRL was 81.6%. Neutropenia was the major side effect: G 4 in 43.5% of pts and 15% of cycles but only complicated in 3 pts: two febrile neutropenia (8.4%) and one neutropenic infection (4.3%). In terms of non haematological related toxicity, the more frequent events reported were mild to moderate fatigue and diarrhoea (21.7% of pts each), stomatitis and weight loss (17.4%). No G4 toxicity was seen. One toxic death occurred due to hypovolemic collapse secondary to inadequately treated G3 vomiting and diarrhoea. Other G3 events were stomatitis and infection with unknown ANC (8.7% each), fatigue and amenorrhea (4.3% each). The combination is highly effective with 14 PR validated by an external panel, yielding a RR of 60.9%[95%CI= 38.5 - 80.3] in the first 23 pts. Recruitment is now completed (44 pts), treatment and follow-up are ongoing. Conclusions: This combination with oral VRL on day 15 avoiding hospitalisation, is highly efficient (RR=60.9%) and safe. VRL iv./oral D1/D15 -DTX D1 every 3-week cycle is an attractive option to combine DTX and VRL in every day practice for MBC. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration IRPF
Thermal Effects on the Gas Transmission Properties of Ionomers Used in Food Packaging Applications (1996)

Polyethylene-based ionomers, due to the presence of ionic aggregates, display a time-dependent crystalline morphology if submitted to thermal treatments. As a consequence gas permeability, which is strongly affected by physical morphology, is also found to be time dependent in previously thermally treated ionomer samples. The effect of sample exposure at 65°C and of successive ageing at 35°C on gas transmission properties of three different ethyleneacrylic acid ionomers (characterized by a different amount of acrylic acid groups, percentage of neutralization and type of counterions) has been investigated. In particular the changes in oxygen and carbon dioxide permeabilities due to thermal treatments at 65°C and subsequent ageing at 35°C have been monitored. X-Ray diffraction analysis and differential scanning calorimetry have been used to elucidate these changes in transport properties.
Studies on the distribution of (1-14C) pantothenic acid in rats. (1980)

The distribution of (1-14C) pantothenic acid was studied in two different experiments with rats. Single dose kinetics were carried out over a period of 168 hours. In this experiment it could be shown that besides the urinary and faecal output a third route of excretion exists: the respiratory pathway. The tissues with the highest retention capacity were the kidneys, pituitary gland, heart, muscle, liver and the adrenal glands. In a second experiment - performed as steady state study, lasting 35 days - during the investigated period and finally in the steady state the above mentioned tissues showed the highest affinity for pantothenic acid, indicating an intensive metabolism of this vitamin. These results are discussed, especially towards pantothenic acid and acetyl coenzyme A-depending functions.
Production of 9‐hydroperoxy‐γ‐linolenic acid by soybean lipoxygenase in a two‐phase system (1988)

Abstract 9‐Hydroperoxy‐γ‐linolenic acid (9‐GOOH) was produced selectively by soybean lipoxygenase (LG) from γ‐linolenic acid (GLA) using a two‐phase (borate buffer, pH 6.5/hexane) system at a low temperature (10°C) with some anionic surfactants that showed little inhibitory effect on the enzyme at pH 6.5. The system avoided the inhibitory effect of a higher substrate concentration and of hydroperoxide as well as low substrate solubility in an aqueous system. Not lipoxygenase‐2 (LG2) but lipoxygenase‐1 (LG1) was indicated to be responsible for the production of 9‐GOOH. Among the anionic surfactants examined, acetate and sarcosinate were shown to be suitable, but phosphate was not. Ca 2+ increased the 9‐GOOH productivity. The LG1 fraction gave the maximum yield of 35% with 0.5 mM Ca 2+ , ECT‐3N (anionic surfactant, acetate) at 10°C and at 4.8 mM GLA in an emulsion.
Experimental Investigation of Twin Jet Impinging on the Ground With and Without Free Stream (2002)

The flow underneath a flat plate simulating the underbody of a VSTOL aircraft was studied experimentally. Twin jets arranged in tandem were allowed to impinge on the ground at two height-over-jet-diameter ratios. Data were obtained via particle image velocimetry along the plane containing the two jet axes and five planes parallel to the free stream. Results disclose in great detail the formation of the fountain jet and the recirculating regions between the jets and the fountain jet. The effect of the free stream is quantified, indicating at what velocity ratios these secondary motions are deflected downstream or almost eliminated.
Esthesioneuroblastoma (1993)

Forty-nine patients with esthesioneuroblastoma were treated at the Mayo Clinic between 1951 and 1990. Their clinical manifestations and treatment results were reviewed to identify possible prognostic factors. The 5-year survival rate for all patients was 69%. Tumor progression occurred in 25 patients (51%; no local control in 6 and local recurrence in 19). Metastasis was found in 15 patients (31%; regional in 10 and distant in 9). Nineteen patients died directly from metastatic or intracranial tumor extension. The pathological grade of the tumor was the most significant prognostic factor identified. The 5-year survival rate was 80% for the low-grade tumors and 40% for the high-grade tumors (P = 0.0001). Surgical treatment alone is effective for low-grade tumors if tumor-free margins can be obtained. Radiation is used for low-grade tumors when margins are close, for residual or recurrent disease, and for all high-grade cancers. The poor prognosis associated with high-grade tumors may also mandate the addition of chemotherapy. Recurrent tumor and regional metastasis should be treated aggressively because this approach has been shown to be worthwhile. A craniofacial resection is now the surgical procedure performed in all cases. Because recurrence can occur after 5 or even 10 years, long-term follow-up is mandatory.
A scalable and fully distributed architecture for Ethernet switching (2003)

We propose a new scalable et flexible architecture for Ethernet switching. First we identify the legacy bottlenecks in classical Ethernet backbones: mainly the tree topology and the redundant packet forwarding decisions. Then we describe how a fully distributed communication architecture, based on proven, high-performance computing concepts (source routing, multistage interconnection, wormhole switching) can provide a scalable backbone inside, with Ethernet compatibility outside. Thanks to carefully placed intelligence, materialized as "network processors", we show that not only scalability is enhanced but also flexibility and global transistor count. We present a prototype of this architecture implemented with Myrinet technology.
[Surgical therapy of serious heart rhythm disorders]. (1994)

The author summarizes his experience with operations in 40 patients. Twenty-one were operated on account of W-P-W syndrome, 9 on account of ventricular tachycardia due to IHD and in 10 patients an automatic defibrillator was implanted. None of the patients died and the results of surgery are satisfactory.
Bumpless transfer for a flexible adaptation of Iterative Learning Control (2011)

This work builds upon a framework for improving trajectory flexibility in systems controlled by Iterative Learning Control (ILC). Here we focus on positioning systems, decomposing a class of trajectories into motion primitives, termed basis tasks. The correct input signal for each basis task is identified in a training routine with ILC. The main development of this paper is a framework to intelligently apply these basis task specific input signals using an adaptation of bumpless transfer techniques. Bumpless transfer is reoriented to seamlessly transition between open-loop ILC signals without attenuating signal content away from the transition points. Experimental results display the effectiveness of the proposed approach on a serial planar positioning robot. Two conditions on basis task sequencing are tested. One which satisfies constraints imposed by previous work, and a relaxed trajectory constraint case designed to further explore trajectory flexibility. Bumpless transfer recovers some of the performance lost by constraint relaxation.
Degradation of biotansformation products of nonylphenol ethoxylates by ozonation and UV/TiO2 treatment (2002)

The degradation kinetics of biotransformation products of nonylphenol polyethoxylates (NPEOs), nonylphenol (NP), nonylphenol monoethoxylate (NP1EO) and nonylphenoxy carboxylic acid (NP1EC), by ozonation and UV/TiO2 (ultraviolet photocatalytic degradation in the presence of titanium dioxide suspension as a catalyst) were investigated using lab-scale reactors. The degradation rate of NP by UV/TiO2 was the highest among the tested NPEOs metabolites, while NP1EC showed the lowest degradation rate. In contrast, ozonation was especially effective for the breakdown of NP1EC. NP could be also degrade efficiently by ozonation, however, it was much less effective for NP1EO decomposition. Degradation of NP by both chemical oxidation processes followed first-order kinetics. The degradation curves of NP1EO and NP1EC could be approximately described by first-order kinetics also, although the degradation of NP1EC by ozonation seemed to follow a second-order kinetic.
Abstract 1525: Inhibition of HGF maturation overcomes cetuximab resistance in colorectal cancer (2022)

Abstract We have previously identified that activation of receptor tyrosine kinases (RTKs) MET and RON contributed to resistance to the EGF receptor (EGFR)-directed therapeutic antibody cetuximab. These findings originated from our in vitro 3D type I collagen cultures of human colorectal cancer (CRC) cell line HCA-7 derivatives CC, SC, and CC-CR. CC are sensitive to cetuximab, while SC and CC-CR are resistant. Both de novo and acquired modes of cetuximab resistance in SC and CC-CR, respectively, could be overcome by crizotinib, a multi-RTK inhibitor that also targets MET and RON. Conversely, exogenous administration of MET ligand, HGF could transiently induce cetuximab resistance which could be further overcome by crizotinib addition. HGF/HGFL are synthesized as inactive precursors and require cleavage by proteases (HGFA, Matriptase, and Hepsin) to be biologically active. To inhibit HGF/HGFL cleavage in cetuximab-resistant cells, we employed inhibitors of HGF/HGFL proteases (ZFH7116 and VD2173) and were able to overcome both de novo and acquired cetuximab resistance. A survey of TCGA datasets indicated that HGF/HGFL were overexpressed in several CRC CMS subtypes. We next expressed human HGF in cetuximab-sensitive CC cells and observed that HGF overexpression imparts cetuximab resistance. Moreover, cetuximab resistance induced by HGF overexpression could be overcome by the downstream MET inhibition (with crizotinib) and we are now testing if the upstream inhibition of HGF proteases (with ZFH7116/VD2173) also overcomes cetuximab resistance. Combined these results indicate that inhibition of HGF cleavage and maturation may be a novel way to overcome resistance to EGFR-targeted therapies in CRC. Citation Format: Ramona Graves-Deal, Galina Bogatcheva, Vivian T. Truong, Vishnu Damalanka, Lidija Klampfer, Robert J. Coffey, James W. Janetka, Bhuminder Singh. Inhibition of HGF maturation overcomes cetuximab resistance in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1525.
Solid electrolytes: Problems and solutions (1986)

Degradation phenomena occurring in sodium ..beta..''-alumina solid electrolytes as a consequence of their use in sodium/sulfur batteries are reviewed. Four classes of degradation are discussed: electrolyte reduction, crack propagation, internal sodium precipitation, and reaction with the polysulfide electrode. While degradation reactions may adversely affect cell life, it has been found that these deleterious effects may be avoided by impurity control of the system and by microstructural modification of the ceramic, including grain size control and zirconia-dispersion toughening.
On The Implementation of Regular Spatial Sampling (RSS) Beamforming for UMTS LCR-TDD (2006)

In this communication a novel beamforming scheme is presented, which is based on regular spatial sampling (RSS) of signals. RSS beamforming allows low-complexity algorithms for smart antennas, while at the same time improving the performance of those systems. An implementation concept is presented, which shows the feasibility of implementing RSS beamforming on today's readily available hardware platforms
Macrophages Induce Cellular Immunity by Activating Th1 Cell Responses and Suppressing Th2 Cell Responses (1998)

Differentiation of naive CD4+ T cells (Th0) into Th1 or Th2 cells determines whether antigen will raise a cellular or a humoral immune response. The maturation pathway chosen by the Th0 cell is often decisive for the outcome of disease and depends among others on the (co-)stimulatory attributes of the APC and the nature and abundance of cytokines provided by the APC and the microenvironment. In this study, we used macrophages, loaded ex vivo with antigen, for inciting Th0 activation and differentiation in vivo. The macrophages were derived from a clonal, immortalized population that both functionally and phenotypically expressed features characteristic of mature macrophages. Injection into syngeneic mice of IFN-gamma-treated, Ag-loaded macrophages induced a primary T cell response, indicated by the occurrence of a proliferative response in vitro after restimulation of splenocytes with Ag. Analysis of the accompanying cytokine secretion revealed high numbers of IFN-gamma-producing Th1 cells and only a few IL-4-secreting Th2 cells. This dominance of Th1 cells had functional implications, reflected in the high titer of Th1 cell-dependent IgG2 Abs and the absence of IgG1, characteristic of humoral immunity. Moreover, administration of Ag-loaded macrophages to mice with an ongoing Th1/Th2 response resulted in a complete suppression of IgG1 production, whereas IgG2 levels remained unaffected. These results demonstrate that macrophages exert APC activity in the organism, strongly skew primary responses to cellular immunity, and in addition suppress an already generated Th2-dependent humoral response, thus characterizing these cells as Th1-oriented APC.
Silicon-Organic Hybrid (SOH) Frequency Comb Source for Data Transmission at 784 Gbit/s (2013)

We demonstrate a frequency comb generator using silicon-organic hybrid (SOH) electrooptic modulators to obtain flat-top comb spectra.This is the first demonstration of a modulator-based frequency comb generator on silicon.The viability of the device is confirmed in a data transmission experiment achieving an aggregate data rate of 784 Gbit/s.
Studies on dynamic changes of water contents of soil under different land uses in Liudaogou basin (2006)

Based on a case study of a slope in the wind-water erosion crisscross region on the Loess Plateau, the dynamic changes of soil water under different land uses were analyzed during the rain season. The results show that the variation of 0～300cm soil water storage of four types of land uses are different, ranking in following order: degraded alfalfa landwastelanddegraded woodlandfarmland, with a weak spatial variability. The decreasing tendencies of soil water in a soil profile with the increase of the depth are obviously different among the different land uses, the order of the variability is as follows:waste landdegraded woodlanddegraded alfalfafarmland. The soil water content and the plant biomass fluctuate along the slope from the top to its bottom showing that better vegetation consumes more soil water.