gebhart/patrepeval huggingface dataset:
Interleukin-5 is a human basophilopoietin: induction of histamine content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors (1991)

Cytokine-induced differentiation of basophils may contribute to various inflammatory processes. We examined the effects of recombinant human interleukin-5 (IL-5) and other human cytokines in vitro on myeloid colony formation in methylcellulose and on alkaline passaged HL-60 basophilic cell differentiation. Myeloid colonies (CFU-C) at day 14, formed in the presence of either IL-3, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), or G-CSF included peripheral blood- derived progenitors of the eosinophil/basophil lineage. IL-5 stimulated a greater proportion of basophil-containing, histamine-positive, eosinophil-type colonies compared with GM-CSF, IL-3, or G-CSF. IL-5 also stimulated dose-dependent increases in histamine content of alkaline-passaged, butyrate cotreated HL-60 cells. The concentration of IL-5 required for half-maximal induction of HL-60 histamine content was similar within twofold to that needed for half-maximal stimulation of the multifactor dependent TF-1 erythroleukemic cell line. Neutralizing rat monoclonal antibodies to human IL-5 were developed and used to demonstrate that each of these IL-5 bioactivities could be specifically blocked. We conclude that in addition to its previously described eosinophil differentiation activity, IL-5 may be considered a basophilopoietin.
Experimental immunization of hamsters with an EDTA extract of Leptospira interrogans, serovar icterohaemorrhagiae. (1996)

The EDTA extract was prepared from the Leptospira interrogans serovar icterohaemorrhagiae. When inoculated subcutaneously in hamsters it conferred protection from challenge with virulent leptospires with a low dose (10 micrograms/ml) and low agglutinating antibody (40). The protection of animals obtained by the EDTA extract opens up the perspective of its use as a component of a vaccine for the control of leptospirosis.
Chemistry of thiazole, I. Synthesis and properties of 2,3,5,6‐tetrahydro‐6‐(3‐methylbenzofuran‐2‐yl)imidazo[2,1‐<i>b</i>]thiazole (1982)

Chemie des Thiazols, I. Synthese und Eigenschaften von 2,3,5,6‐Tetrahydro‐6‐(3‐methylbenzofuran‐2‐yl)‐imidazo[2,1‐ b ]thiazol The main part of the paper was reported at „Third International Symposium of Furan Chemistry”︁ at Smolenice, May 1979. Die Titelverbindung 13 wird auf zwei Wegen ausgehend von 2‐Hydroxyacetophenon ( 1 ) über das Benzofuran‐Derivat 7 und die Thiazolidine 9 bzw. 10 erhalten.
The contribution of chemistry to new Marangoni mass-transfer instabilities at the oil/water interface (1984)

Spontaneous interfacial motions appear at an interface between two immiscible phases in a state far from equilibrium, e.g. an aqueous phase of an organic acid or a complex ion and an organic phase of a long-chain surfactant molecule. The instabilities observed are related to variations in the interfacial tension. It is shown that they resemble the well known Marangoni effect by considering interfacial convection and the coupling between diffusion and convection fluxes, but they differ by the presence of chemical reactions. The notion of assisted desorption is defined in order to interpret the experiments.The analysis of this phenomenon could be useful in determining the optimal conditions for obtaining convective interfacial transfer to enhance liquid–liquid extraction processes.
Beam-positioning radar systems utilising continuous scanning techniques (1965)

This paper describes the advantages that accrue from the use of an electronic beam-positioning radar system for both searching and tracking a complex target environment. It is also shown that the principal properties of such a system may be achieved using a radar system with transmitting and receiving beams scanning continuously at different rates. This technique results in the same power-distribution efficiency, but less efficient time utilisation, compared with an ideal beam-positioning radar.
Sun Exposure, Sun Protection, and Vitamin D (2005)

Objectives: To examine during what behaviors people apply sunscreen and to assess the relationship to UV exposure monitored by personal dosimetry and diaries.Design: Open prospective observational study.Setting: University hospital.Participants: A convenience sample of 340 Danish volunteers: children, adolescents, indoor workers, sun worshippers, golfers, and gardeners (age range, 4-68 years).Intervention: Subjects recorded sunscreen use and sun-exposure behavior in diaries and carried personal, electronic UV dosimeters, measuring time-stamped UV doses continuously, during a median of 119 days covering 346 sun-years (1 sun-year equals 1 subject participating during 1 summer season).Main Outcome Measures: Associations between sunscreen use and age, sex, skin type, occupation, sunburn, UV exposure doses, and behavior; and adequate application density and sun protection factor required to prevent sunburn.Results: There were great variations in sunscreen use, which was highly correlated with risk behavior (sunbathing or exposing the upper body) (r = 0.39; P<.001). Sunscreens were used on a median of 5 days per sun-year (range, 1 day for gardeners to 16 days for sun worshippers). Ten percent of females and 41% of males never used sunscreens. Females used sunscreens more but also had more unprotected risk behavior than males (8 days vs 4 days; P<.001). Sunscreen use was not correlated with age, and children had as much unprotected risk behavior as adults. Sunscreens were used on 86% of the days with risk behavior in southern Europe vs 20% in northern Europe (P<.001). The UV doses were significantly higher on days with sunscreen (P≤.03) and on sunburn days (P<.001). The median sun protection factor was 10.5. The sun-protecting effect corresponded to an application density of 0.5 mg/cm2.Conclusions: Days with sunscreen correlated not with days without risk behavior, but with days “sunbathing with the intention to tan,” indicating that sunscreens were used as tanning aids to avoid sunburn.
HISMEDCAR, UN SOFTWARE EDUCATIVO PARA LA ENSEÑANZA DE LA HISTORIA DE LA MEDICINA EN CÁRDENAS. (2011)

Cardenas es una ciudad historica conocida como la Ciudad de las Primicias. Exhibe aportes significativos a la Medicina y atesora primicias medicas que reflejan su papel en la Medicina cubana. Las Tecnologias de Informacion y Comunicaciones marcan la distincion de este momento historico en relacion con el conocimiento del pasado. Se establecio como objetivo elaborar un software educativo para contribuir a elevar el nivel de conocimientos de los estudiantes de Medicina del municipio acerca de la historia de la Medicina en la localidad. “HisMedCar”, se desarrollo en el Policlinico Universitario “Jose Antonio Echeverria” entre septiembre de 2009 y enero de 2010. Se comprobo primero que no existia un producto similar a este. Para la confeccion del software se utilizo: editor de paginas Webs Macromedia Dreamweaver version 8, Adobe PhotoShop version 9 y Xara WebStyle version 3. El producto consta de texto basico, galerias de imagenes y libros digitales. El universo estuvo constituido por 105 estudiantes de Medicina, Estomatologia y Psicologia y se utilizo una muestra de 53 que consintieron en participar en el estudio. Se aplico una encuesta inicial sobre el tema la cual arrojo un 20% del total de estudiantes evaluados de Regular y un 70% evaluados de Mal. Se demostro, despues de la aplicacion del software, una mejoria significativa del nivel de conocimientos al predominar estudiantes evaluados de Bien representando el 90 % del total mientras que ninguno fue evaluado de Mal. El 100% de los encuestados poseen un alto nivel de satisfaccion con el uso del producto.
Exceptionally Strong Electronic Coupling in Crystalline Perylene Diimides via Tuning (2011)

The first series of core-unsubstituted perylene diimides exhibiting a long and tunable λmax in the solid state has been prepared. Unprecedentedly long λmax values have been achieved, which implies the presence of exceptionally strong electronic coupling. A tuning mechanism on the basis of competing subunits has been proposed.
The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence (2012)

The collapse of thymic stromal cell microenvironment with age and resultant inability of the thymus to produce naive T cells contributes to lower immune-surveillance in the elderly. Here we show that age-related increase in 'lipotoxic danger signals' such as free cholesterol (FC) and ceramides, leads to thymic caspase-1 activation via the Nlrp3 inflammasome. Elimination of Nlrp3 and Asc, a critical adaptor required for inflammasome assembly, reduces age-related thymic atrophy and results in an increase in cortical thymic epithelial cells, T cell progenitors and maintenance of T cell repertoire diversity. Using a mouse model of irradiation and hematopoietic stem cell transplantation (HSCT), we show that deletion of the Nlrp3 inflammasome accelerates T cell reconstitution and immune recovery in middle-aged animals. Collectively, these data demonstrate that lowering inflammasome-dependent caspase-1 activation increases thymic lymphopoiesis and suggest that Nlrp3 inflammasome inhibitors may aid the re-establishment of a diverse T cell repertoire in middle-aged or elderly patients undergoing HSCT.
809 A fundamental study of simulation for wire-harnesses using interatomic potential (2010)

A fu ndamental study of simu ation for wire
A Defect in NIPAL4 Is Associated with Autosomal Recessive Congenital Ichthyosis in American Bulldogs (2017)

Autosomal recessive congenital ichthyosis in the American bulldog is characterized by generalized scaling and erythema with adherent scale on the glabrous skin. We had previously linked this disorder to NIPAL4, which encodes the protein ichthyin. Sequencing of NIPAL4 revealed a homozygous single base deletion (CanFam3.1 canine reference genome sequence NC_06586.3 g.52737379del), the 157th base (cytosine) in exon 6 of NIPAL4 as the most likely causative variant in affected dogs. This frameshift deletion results in a premature stop codon producing a truncated and defective NIPAL4 (ichthyin) protein of 248 amino acids instead of the wild-type length of 404. Obligate carriers were confirmed to be heterozygous for this variant, and 150 clinically non-affected dogs of other breeds were homozygous for the wild-type gene. Among 800 American bulldogs tested, 34% of clinically healthy dogs were discovered to be heterozygous for the defective allele. More importantly, the development of this canine model of autosomal recessive congenital ichthyosis will provide insight into the development of new treatments across species.
Epidemiological Surveillance of Imported Malaria in Calgary, 2007-2011 (2012)

Background: The increase in intercontinental travelling and migration has resulted in a notable rise in the number of malaria cases detected within the industrialized countries. 1,2 The objective of this study was to retrospectively analyze the epidemiological situations of imported malaria in Calgary, Canada, between year 2007 and 2011. Methods: This study involved patients who tested positive for malaria in Calgary between January 2007 and December 2011. The data were gathered from Calgary Laboratory Services (CLS) electronic malaria history form database. Information was obtained on pre-travel advice, reason for travel, countries with malaria visited, types of prophylaxis taken, and types of treatment received. Results: During the five years, a total of 168 imported malaria cases have been reported. Greater than 80% of these cases comprised of Plasmodium falciparum and Plasmodium vivax infections. The highest proportions of P. falciparum were contracted in Africa, and by contrast, the highest proportions of P. vivax were contracted in Asia. The prevalence of malaria was significantly higher in males than in females. The most common reason for travel was visiting friends and relatives (VFR), and the top three destinations for VFR were Sudan (25.0%), India (16.1%), and Nigeria (16.1%).  Incidence of malaria cases were higher in certain wards of Calgary located in North East than in other quadrants. Conclusions: During the 5 year period, there was an increasing trend in the total number of annual imported malaria cases and in the total number of P. falciparum infections, with little fluctuation. Only 24.6% of the malaria patients have indicated using prophylaxis prior to their travelling and migration, increasing their risk of acquiring malaria. In order to improve health outcomes in travelers related to malaria, future public health interventions focused on recent immigrants may be necessary.
A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease (2009)

Overall, there was no significant difference in the rates of death and major cardiovascular events between patients undergoing prompt revascularization and those undergoing medical therapy or between strategies of insulin sensitization and insulin provision. (ClinicalTrials.gov number, NCT00006305.)
Prediction-based virtual instance migration for balanced workload in the cloud datacenters (2011)

Datacenters in the cloud today provide virtualized resources of CPU, memory, disk, and networks so that millions of users can use the services at the same time in an efficient and scalable way. One of the major challenges in these datacenters is load balancing and shifting. As a huge number of requests are sent to a particular datacenter or a group of servers are asked to process more than their fair share, some of the servers are overloaded, slowed down, hot spots are created, and even hardware failures may occur. This unbalanced load in the end deteriorates the performance of the entire system easily. In this paper, we propose a load balancer that aims at alleviating hot spots and distributing the load from overloaded servers to underutilized servers. Our load balancer monitors the loads of the servers, detects indications of overloading, then migrates virtual instances from overloaded servers to target servers. We have implemented the load balancer in a real system using the Xen hypervisor. We have also conducted an event-driven simulation to evaluate the performance of our system on a large-scale. Our results indicate that our reactive-predictive load balancing algorithm helps balance load among servers in the cloud as much as the best-case scenario from the exhaustive search with much less overhead.
Enzymic determination of branched-chain amino acids and 2-oxoacids in rat tissues. Transfer of 2-oxoacids from skeletal muscle to liver <i>in vivo</i> (1980)

1. A procedure is described for the purification of leucine dehydrogenase (EC 1.4.1.9) from Bacillus subtilis. 2. The preparation is suitable for the quantitative assay of branched-chain amino acids and their 2-oxoacid analogues. 3. The content of total branched-chain 2-oxoacids in freeze-clamped liver, kidney, heart or mammary gland of fed rats is less than 5 nmol/g fresh wt. Higher amounts are present in skeletal muscle and arterial blood (25 +/- 4 nmol per g fresh wt., and 33 +/- 6 nmol per ml respectively; means +/- S.D. of 3 and 11 animals respectively). The values are not significantly affected by starvation for 24 h. 4. Arteriovenous difference measurements show that considerable amounts of branched-chain 2-oxoacids are released by skeletal muscle into the circulation and similar amounts are removed by the liver (about 1 mmol/24 h in a 400 g rat).
Immunochemical tests of potential fertility (1992)

Conference Article| February 01 1992 Immunochemical tests of potential fertility W. P. Collins W. P. Collins 1Diagnostics Research Unit, Department of Obstetrics and Gynaecology, Kings College School of Medicine and Dentistry, Denmark Hill, London SE5 8RX, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1992) 20 (1): 234–237. https://doi.org/10.1042/bst0200234 Article history Received: August 28 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation W. P. Collins; Immunochemical tests of potential fertility. Biochem Soc Trans 1 February 1992; 20 (1): 234–237. doi: https://doi.org/10.1042/bst0200234 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: LH, luteinizing hormone, E3G, oestrone 3-glucuronide, P3G, 5β-pregnanediol-3α-glucuronide, EMU, early morning urine, CUSUM, cumulative sum analysis, F, fluorescein, E17βG, oestradiol 17β-glucuronide, E3S oestrone 3-sulphate This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County (2010)

The OOA are a closed founder population in which a modest number of founders account for the genetic variation present in the current OOA population. Improvements to the PedHunter software will be useful in future studies of both the OOA and other populations with large and computerized genealogies.
STRUCTURAL CHANGES AND SURVIVAL OF CELLS IN TRANSPLANTED BLOOD VESSELS. (1908)

When blood vessels, e. g., the carotid arteries, are anastomosed end to end,<i>in situ</i>, practically no change is observed in the histologic structure of the walls.<sup>1</sup>If the central end of an artery, e. g., the common carotid, be anastomosed to the peripheral end of a vein, e. g., the external jugular, the result is usually some alteration in the structure of both artery and vein, evidenced in the former by a decrease and in the latter by an increase in the thickness of the wall.<sup>2</sup>In rapid transplantation of segments of blood vessels in animals of the same species, with only a short interval of anemia of the segment,<sup>3</sup>as well as in heterotransplantations,<sup>4</sup>marked histologic changes occur, as a rule, in the segments, be they arteries or veins. Ordinarily this consists of a dilatation of the lumen and a thickening of the wall.
[Comparison in changes of glutamate level in the rat nucleus accumbens induced by D1- and D2-dopamine receptors during feeding]. (2002)

The influence of dopamine D1- and D2-like receptors blockage on glutamate level in the n. accumbens of Sprague-Dawly rats during feeding was investigated by in vivo microdialysis combined with HPLC-EC analysis. Food intake resulted in a decrease in extracellular glutamate level. Infusion of D1-like dopamine receptor-blocker (SCH-23390, 0.01 mM) into the n. accumbens did not change this effect. Infusion of D2-like dopamine receptor-blocker (raclopride, 0.1 mM) into the n. accumbens caused an increase in extracellular glutamate level during feeding. The findings suggest, that decrease in extracellular glutamate level in n. accumbens is caused by dopamine D2-like, but not D1-like receptors activation.
PECULIAR ELONGATED AND SICKLE-SHAPED RED BLOOD CORPUSCLES IN A CASE OF SEVERE ANEMIA (1910)

This case is reported because of the unusual blood findings, no duplicate of which I have ever seen described. Whether the blood picture represents merely a freakish poikilocytosis or is dependent on some peculiar physical or chemical condition of the blood, or is characteristic of some particular disease, I cannot at present answer. I report some details that may seem non-essential, thinking that if a similar blood condition is found in some other case a comparison of clinical conditions may help in solving the problem. <h3>History.</h3> —The patient was an intelligent negro of 20, who had been in the United States three months, during which time he was a student in one of the professional schools in Chicago. His former residence had been Grenada, West Indies, where he had been born and brought up, one of a family of four children, all living, and all well with the
Fast and accurate leaf verification for dynamic multileaf collimation using an electronic portal imaging device (2002)

A prerequisite for accurate dose delivery of IMRT profiles produced with dynamic multileaf collimation (DMLC) is highly accurate leaf positioning. In our institution, leaf verification for DMLC was initially done with film and ionization chamber. To overcome the limitations of these methods, a fast, accurate and two-dimensional method for daily leaf verification, using our CCD-camera based electronic portal imaging device (EPID), has been developed. This method is based on a flat field produced with a 0.5 cm wide sliding gap for each leaf pair. Deviations in gap widths are detected as deviations in gray scale value profiles derived from the EPID images, and not by directly assessing leaf positions in the images. Dedicated software was developed to reduce the noise level in the low signal images produced with the narrow gaps. The accuracy of this quality assurance procedure was tested by introducing known leaf position errors. It was shown that errors in leaf gap as small as 0.01-0.02 cm could be detected, which is certainly adequate to guarantee accurate dose delivery of DMLC treatments, even for strongly modulated beam profiles. Using this method, it was demonstrated that both short and long term reproducibility in leaf positioning were within 0.01 cm (1sigma) for all gantry angles, and that the effect of gravity was negligible.
Canonical modelling of coorbital motion in Hill's problem using epicyclic orbital elements (2003)

This paper presents a Hamiltonian approach to modelling relative coorbital motion based on derivation of canonical coordinates for the relative coorbital dynamics. The Hamiltonian formulation facilitates the modelling of high-order terms and orbital perturbations while allowing us to obtain closed-form solutions to the relative coorbital motion in Hill's restricted three-body problem. First, the Hamiltonian is partitioned into a linear term and a high-order term. The Hamilton-Jacobi equations are solved for the linear part by separation, and new constants for the relative motions are obtained, called epicyclic orbital elements. The influence of the gravitational interaction between the coorbiting satellites is incorporated into the analysis by a variation of parameters procedure.
Extensible 3D architecture for superconducting quantum computing (2017)

Using a multi-layered printed circuit board, we propose a 3D architecture suitable for packaging superconducting chips, especially chips that contain two-dimensional qubit arrays. In our proposed architecture, the center strips of the buried coplanar waveguides protrude from the surface of a dielectric layer as contacts. Since the contacts extend beyond the surface of the dielectric layer, chips can simply be flip-chip packaged with on-chip receptacles clinging to the contacts. Using this scheme, we packaged a multi-qubit chip and performed single-qubit and two-qubit quantum gate operations. The results indicate that this 3D architecture provides a promising scheme for scalable quantum computing.
Genes of Cholesterol Metabolism in Human Atheroma (2005)

We show the presence and induction of perilipin in atheroma. This overexpression and the coordinated modifications of expression of key regulatory factors for cholesterol metabolism could favor cholesterol accumulation.