gebhart/patrepeval huggingface dataset:
An Improved Protocol for the Preparation of 3‐Pyridyl‐ and Some Arylboronic Acids. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Effect of ω-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders (2016)

anzctr.org.au Identifier: 12608000475347.
Abstract 15130: Biophysical Effects of a Hyaluronic Acid Based Hydrogel on Average Peak Stress of the Left Ventricular Wall Post Myocardial Infarction (2013)

Background: : A common event following a myocardial infarction (MI) is left ventricular (LV) remodeling characterized by mural wall thinning of the MI region and LV dilation, resulting in increased...
Elver: Recommending Facebook pages in cold start situation without content features (2013)

Recommender systems are vital to the success of online retailers and content providers. One particular challenge in recommender systems is the “cold start” problem. The word “cold” refers to the items that are not yet rated by any user or the users who have not yet rated any items. We propose Elver to recommend and optimize page-interest targeting on Facebook. Existing techniques for cold recommendation mostly rely on content features in the event of lacking user ratings. Since it is very hard to construct universally meaningful features for the millions of Facebook pages, Elver makes minimal assumption of content features. Elver employs iterative matrix completion technology and nonnegative factorization procedure to work with meagre content inklings. Experiments on Facebook data shows the effectiveness of Elver at different levels of sparsity.
Dependence on age of interference with phoneme perception by first- and second-language speech maskers (2015)

This study investigated the differences in first-language-based (L1-based) phonetic processing for second language (L2) phonemes among different age groups of adults. A speech-in-speech masking paradigm was utilized to examine the contribution of the L1-based processing. A phoneme identification task in one language was conducted in the presence or absence of an interferer of a masker of the same or a different language. The degree of interference (i.e., the decrease in identification performance) was postulated to increase as the similarity of underlying processes for the target and masker increases. Experiment 1 was conducted to test the effectiveness of the paradigm. As expected, the interference increased as the similarity of underlying processes for the target and masker increased. Experiment 2 examined the perception of English /r/–/l/ and other phonetic contrasts by Japanese listeners in various adult age groups, to examine whether the degree of interference differs depending on the putative degrees of L1-based processing and on age. The results demonstrated such differences and showed that the L1-based processing can be estimated from the decrease in the identification performance. They also suggested that the perception of /r/–/l/ in the initial singleton and initial cluster positions was high L1-based in older adults.
Self-assembled molecular patterns of fatty acid on graphite in the presence of metal ions (2006)

The stripe phase formed by long-chain alkane derivatives on the graphite lattice provides a unique opportunity for the study of molecular adsorption, aggregation, and reaction on patterns. Fatty acids, such as arachidic acid (AA), self-assemble on graphite into a sheet of parallel stripes with a periodicity of twice its molecular chain length. The molecular pattern is thus defined precisely by the size and functionality of the headgroup and tailgroup of the amphiphile. Complexation of metal ions to AA fixes the number and location of the ion, which can serve as a precursor to semiconductor nanocrystal arrays. In order to understand the effect of the ion complexation, we carry out atomic force microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR) investigations of AA self-assembly in the presence of various metal ions. While the stripe orientation is dictated by the graphite lattice and the stripe periodicity is determined by the AA chain length, the size, shape, and degree of order of the stripe crystalline domain are influenced by the metal ion bond strength to the carboxylic ligand. The change of morphology in the self-assembled pattern shows a trend along the Irving-Williams series.
Uridine sugar nucleotides modified in their nucleoside moieties and their effect on lipid-linked saccharide formation <i>in vitro</i> (1986)

Uridine diphospho glucose (UDP-Glc) and uridine diphospho N-acetylglucosamine (UDP-GlcNAc), modified in the uridine moiety by either periodate oxidation of the ribose ring or substitution at position 5 of the uracil ring with fluorine, have been tested as potential inhibitors of glucosyl monophosphoryl dolichol (Glc-P-Dol) or N,N-diacetylchitobiosyl pyrophosphoryl dolichol [GlcNAc)2-PP-Dol) assembly in chick embryo cell membranes. The periodate oxidised sugar nucleotides inhibited glycosyl transfer from their respective natural counterparts by 50% at 230 micron periodate oxidised UDP-Glc and 70 micron periodate oxidised UDP-GlcNAc respectively. Inhibition in both cases was irreversible and addition of exogenous Dol-P stimulated only the residual non-inhibited reaction. Periodate oxidised UDP-GlcNAc preferentially inhibited the transfer of GlcNAc to GlcNac-PP-Dol. The sugar nucleotide containing 5-fluorouridine were, on the other hand, alternative substrates for Glc-P-Dol or (GlcNAc)2-PP-Dol synthesis. FUDP-Glc was a good substrate for Glc-P-Dol formation; having Km and Vmax values equal to those of UDP-Glc, whereas FUDP-GlcNAc was a less efficient substrate for the formation of (GlcNAc)2-PP-Dol; having Km and Vmax values one half and one third respectively of those of UDP-GlcNAc.
Synthesis of Neooxazolomycin (2007)

Neooxazolomycin is a member of a group of antibiotics that contain the oxazole-polyene-lactam-lactone motifs. Neooxazolomycin exhibits a range of activities including antibiotic, antiviral, and antitumor properties. The present synthesis features an intramolecular Tamao hydro­silylation (A to B) to generate a trisubstituted alkene stereospecifically.
Spin Waves in the Cubic Ferrimagnet<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ho</mml:mi></mml:mrow><mml:mrow><mml:mn>0.88</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Tb</mml:mi></mml:mrow><mml:mrow><mml:mn>0.12</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Fe</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1976)

Using neutron spectrometry we have investigated the magnon dispersion relation for the ferrimagnetic cubic Laves compound ${\mathrm{Ho}}_{0.88}$${\mathrm{Tb}}_{0.12}$${\mathrm{Fe}}_{2}$ at room temperature and 12 K. The results are described surprisingly well by a very simple near-neighbor exchange model which includes only iron-iron and iron-rare-earth interactions, crystal field anisotropy, and temperature renormalization that is derived from the sublattice magnetization.
Studies on Oxidation of Tocopherols. II. Oxidation Products of Tocopherol Model Compounds with Oxygen-Metal Complex (1978)

Oxidation of the model compounds of tocopherols with bis (salicylidene) ethylenediiminocobalt (1) was examined. Oxidation of 6-hydroxy-2, 2, 5, 7, 8-pentamethylchroman (2) in methanol gave 12.8% of trimer (3), 8.3% of spirodienonedimer (4), 3.7% of 1-(6-hydroxy-2, 2, 7, 8-tetramethylchroman-5-yl)-2-[5, 6-dimethyl-2-(3-hydroxyisoamyl)-p-benzoquinon-3-yl] ethane (5), and 20.3% of 2-(3-hydroxyisoamyl)-3, 5, 6-trimethyl-p-benzoquinone (6), while that of 6-hydroxy-2, 2, 5, 8-tetramethylchroman (9) gave 21.2% of 6-hydroxy-2, 2, 5, 8-tetramethyl-7-(2, 2, 5, 8-tetramethyl-6-chromanyloxy) chroman (10) and 8.9% of 3, 6-dimethyl-2-(3-hydroxyisoamyl)-p-benzoquinone (11). The reaction of 6-hydroxy-2, 2, 7, 8-tetramethylchroman (12) in methanol afforded 49.6% of 2, 2, 7, 8-tetramethyl-5, 6-chromandione (13), 5.3% of 8-methoxymethyl-2, 2, 7-trimethyl-5, 6-chromandione (14), and 6.2% of 1, 2-bis (2, 2, 7-trimethyl-5, 6-chromandion-8-yl) ethane (15). The structure of 13 and 14 was determined by deriving them to phenazine derivatives, 2, 3-dihydro-3, 3, 5, 6-tetramethyl-1H-pyrano [3, 2-a] phenazine (16) and 2, 3-dihydro-5-methoxymethyl-3, 3, 6-trimethyl-1H-pyrano [3, 2-a] phenazine (17), respectively. The reaction of 12 in benzene or dimethylformamide gave 6-hydroxy-2, 2, 7, 8-tetramethyl-5-(2, 2, 7, 8-tetramethyl-6-chromanyloxy) chroman (18) (28.6% from benzene, 13.8% from dimethylformamide), 6-hydroxy-5-(6-hydroxy-2, 2, 7, 8-tetramethylchroman-5-yl)-2, 2, 7, 8-tetramethylchroman (19) (15.2 and 3.5%), 13 (24.3 and 40.9%), and 15 (1.9 and 10.0%). Oxidation of 6-hydroxy-2, 2, 8-trimethylchroman (21) gave 4.8% of 6-hydroxy-2, 2, 8-trimethyl-5-(2, 2, 8-trimethyl-6-chromanyloxy) chroman (22), 4.8% of 6-hydroxy-5-(6-hydroxy-2, 2, 8-trimethylchroman-5-yl)-2, 2, 8-trimethylchroman (23), 2.7% of trimer (24), and 19.7% of 2, 2, 8-trimethyl-5, 6-chromandione (25). The structure of 25 was determined by deriving it to the phenazine derivative, 2, 3-dihydro-3, 3, 5-trimethyl-1H-pyrano [3, 2-a] phenazine (26). The reaction of 2, 2-dimethyl-6-hydroxychroman (27) afforded 3.5% of 5-(2, 2-dimethyl-6-chromanyloxy)-6-hydroxychroman (28), 2.1% of 2, 2-dimethyl-5-(2, 2-dimethyl-6-chromanyloxy)-6, 7-chromandione (29), and 1.3% of 2, 2-dimethyl-6-hydroxy-5-(6-hydroxy-2, 2-dimethylchroman-5-yl) chroman (30). Thus, oxidation with 1 resulted in the simultaneous progress of introduction of oxygen and carbon-oxygen or carbon-carbon coupling.
Enzymes of Glucose Catabolism in a Member of the Psittacosis Group (1965)

Moulder, James W. (University of Chicago, Chicago, Ill.), Dorothy L. Grisso, and Robert R. Brubaker. Enzymes of glucose catabolism in a member of the psittacosis group. J. Bacteriol. 89:810-812. 1965.-Extracts of preparations of the agent of meningopneumonitis made from infected chick-embryo allantoic fluid contained three enzymes of the pentose pathway of glucose degradation: glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and phosphoglucose isomerase. Vertical starch-gel electrophoresis showed that the two dehydrogenases were qualitatively different from the corresponding enzymes of the host. Enzymes of the Embden-Meyerhof and Entner-Doudoroff pathways were not found.
Central nervous system mechanisms of pain (2002)

Chronic pain is an immense unsolved clinical problem. Current approaches to this condition are limited by uncertainty about mechanisms of acute and chronic pain in man. Although much progress has been made toward understanding peripheral neural mechanisms of human nociception (Willis, 1985; Price & Dubner, 1977), we have a poor understanding of CNS pain mechanisms. Spinal mechanisms of pain processing are the subject of the previous chapter. The purpose of the present chapter is to review the anatomy and physiology of the ascending spinal pathways and supraspinal centres with painrelated activity. This chapter will focus on the primate nervous systems since there are significant differences between pain transmission in primates and other species such as cats and rats.
Geospatial Data System Architecture for Disaster Risk Management (2017)

Currently, raster information taken for satellite sensors are highly necessary in activities related to disaster risk management. However, the images that come from satellites of polar orbit still present a low temporal resolution and the images that come from satellites of geostationary orbit have a low spatial resolution. Therefore, these limitations affect the processes of analysis of geographic information in the systems and search and rescue activities are not feasible to perform at the required time. Therefore, it is required to introduce new technology to improve disaster risk management by providing coarse and multi-view images. To achieve this, satellite images, aerial photographs captured from airplanes and UAVs, data collected by ground wireless sensor networks and cartographic information are integrated using a new-layered architecture. In this paper, we present a proposal methodology for processing raster information and their integration in an informatics architecture under the concept of data mart that allows the collection and storage for timely distribution of raster and vector geospatial data from different sources. Stakeholders can access to specific data and using this for activities of search and rescue actions of vulnerable population affected by natural disasters.
Medroxalol Combined with Hydrochlorothiazide in the Treatment of Hypertension (1983)

The antihypertensive effect and safety of hydrochlorothiazide administration as a single drug and together with medroxalol were determined in 20 patients with primary hypertension. Following two biweekly intervals on placebo and hydrochlorothiazide, medroxalol was started at 100 mg three times a day and titrated against blood pressure response up to a maximum of 300 mg three times a day. In nine patients the effect of the single and the combined drug therapy on blood pressure during isometric handgrip exercise, on plasma renin activity, and on plasma catecholamines and their deaminated metabolites was investigated. The administration of hydrochlorothiazide was associated with a significant decrease in blood pressure, but heart rate did not change. The addition of medroxalol produced a substantial decrease in blood pressure and heart rate in both the recumbent and upright positions (P less than 0.001). Due to careful titration of medroxalol, orthostatic hypotension was observed only in one patient. Neither hydrochlorothiazide alone nor the combined drug regimen prevented or diminished the rise in blood pressure with exercise. Although plasma renin activity decreased during the combined drug therapy, there was no correlation between the initial levels or the change in plasma renin activity and the extent of decrease in blood pressure. The concentration of plasma epinephrine increased during the combined drug period, whereas catecholamine metabolites increased significantly during both periods of the study. It is concluded that medroxalol combined with hydrochlorothiazide constituted a potent and safe antihypertensive therapy for the duration of the present study.
Generalized equivalent circuits for mixed conductors: silver sulfide as a model system (2009)

The generalized equivalent circuit for Hebb–Wagner polarization in the frequency domain proposed by Jamnik and Maier (J Electrochem Soc 146:4183, 1999) includes the space-charge polarization that was previously neglected. In the present work, using a self-coded Fortran program, the completely generalized equivalent circuit is successfully applied to a mixed conducting silver sulfide with an AgI electrode that suppresses the electronic flow. A whole set of fit parameters, such as geometric capacitance, partial conductivities, chemical capacitance or diffusivity, and the blocking and shunting characteristics of electrodes are independently but self-consistently obtained over a range of silver activities, as controlled by a galvanic cell. The interfacial capacitance was found to be much larger than the diffuse space-charge double-layer capacitance and was thus ascribed to the adsorption capacitance at the core of the interface, which should be connected in parallel with the space-charge double-layer polarization. Two simplified equivalent circuits were shown to be good approximations for the spectra at the extreme low and high silver activity, respectively.
Gadolinium Chloride Augments Tumor-Specific Imaging of Targeted Quantum Dots <i>In Vivo</i> (2010)

Nonspecific sequestration of nanoparticles by the reticulo-endothelial system (RES) results in the degradation of image quality of nanoparticle-based imaging. We demonstrate that gadolinium chloride (GdCl3) pretreatment inactivates RES macrophages, thereby increasing circulatory time and amplifying the tumor-specific signal of conjugated nanoparticles in vivo. The experimental results were validated using compartmental modeling, and the rate parameters for the observed kinetics pattern were estimated. This pretreatment strategy could have broad applicability across biomedical applications utilizing theranostic nanoparticles that are sequestered by the RES.
Rapid, Non-Contact Method for Measurement of Si-Wafer Thickness: Principles and Preliminary Results; Preprint (2003)

The thickness of a semiconductor wafer can critically influence mechanical and/or electronic yield of the device(s) fabricated on it. For most microelectronic (surface) devices, the thickness of a wafer is important primarily for mechanical reasons--to provide control and stability of devices by minimizing stresses resulting from various device-fabrication processes. However, for minority-carrier devices, such as solar cells, the entire thickness of the wafer participates in the optical and electronic performance of the device. In either case, control of wafer thickness through careful measurement is a fundamental requirement in the commercial fabrication of electronic devices.
ESTIMATION FOR WEAR LIFE OF HEAVY DUMP TRUCK TIRE (1984)

Immunohistochemical and immunophenotypic analyses were performed on 278 cases of karyotypically abnormal non-Hodgkin's lymphoma (NHL). Excluding cases of lymphoblastic lymphoma or mycosis fungoides, 20 cases showed evidence of non-B cell lineage. T cell lineage was proven by genotypic and immunophenotypic analyses in 15 of the 20 cases; five were of ambiguous lineage. All of the non-B lineage cases were of diffuse histology with a large cell component (DLCL). Twelve cases expressed the Ki-1 antigen; five of these cases also demonstrated a translocation with a break at 5q35. Patients with Ki-1 positive DLCL and t(5q35) had a younger median age compared with non-B cell DLCL without t(5q35). The Ki-1 positive patients had a higher frequency of skin involvement and lower incidence of bone marrow involvement compared with Ki-1 negative DLCL. Survival analysis was performed on 86 cases of B cell DLCL and 18 cases of non-B cell DLCL which were serially ascertained prior to receiving cytotoxic chemotherapy. Median duration of complete remission was significantly longer in the B cell compared with the non-B cell DLCL groups; there was only a trend for decreased overall survival in the non-B cell group. Among the subset of non-B cell lymphomas, overall survival of patients with Ki-1 expressing DLCL was significantly longer than those with Ki-1 negative DLCL, who had a median survival of less than a year. These results show that immunophenotypic, immunohistochemical, and cytogenetic markers can define subsets of patients with non-B cell lymphomas with differing clinical characteristics and outcome.
Multidimensional Genome-wide Analyses Show Accurate FVIII Integration by ZFN in Primary Human Cells (2015)

Costly coagulation factor VIII (FVIII) replacement therapy is a barrier to optimal clinical management of hemophilia A. Therapy using FVIII-secreting autologous primary cells is potentially efficacious and more affordable. Zinc finger nucleases (ZFN) mediate transgene integration into the AAVS1 locus but comprehensive evaluation of off-target genome effects is currently lacking. In light of serious adverse effects in clinical trials which employed genome-integrating viral vectors, this study evaluated potential genotoxicity of ZFN-mediated transgenesis using different techniques. We employed deep sequencing of predicted off-target sites, copy number analysis, whole-genome sequencing, and RNA-seq in primary human umbilical cord-lining epithelial cells (CLECs) with AAVS1 ZFN-mediated FVIII transgene integration. We combined molecular features to enhance the accuracy and activity of ZFN-mediated transgenesis. Our data showed a low frequency of ZFN-associated indels, no detectable off-target transgene integrations or chromosomal rearrangements. ZFN-modified CLECs had very few dysregulated transcripts and no evidence of activated oncogenic pathways. We also showed AAVS1 ZFN activity and durable FVIII transgene secretion in primary human dermal fibroblasts, bone marrow- and adipose tissue-derived stromal cells. Our study suggests that, with close attention to the molecular design of genome-modifying constructs, AAVS1 ZFN-mediated FVIII integration in several primary human cell types may be safe and efficacious.
Passive Transfer by Cells of Type II Collagen-Induced Arthritis in Rats (1978)

A C T To investigate the role of immunologic hypersensitivity to collagen in the causation of type II collagen-induced arthritis in rats, passive transfer ex- periments were performed. Wistar/Lewis rats used in these experiments were demonstrated to be histocom- patible by prolonged skin graft survival and mixed lym- phocyte cultures. Popliteal lymph node weight assays excluded a potential for graft-vs.-host reactivity in this strain. 9 of 32 naive rats developed arthritis after in- travenous receipt of pooled spleen and lymph node cells from donors that had been injected intradermally with type II collagen emulsified in incomplete Freund's adjuvant. This passively transferred synovitis was evi- dent clinically as well as histologically. In control cell transfer experiments involving a total of 97 recipients, transfer of arthritis was shown to require viable cells sensitized to type II collagen. These controls included 17 rats receiving cells from unimmunized donors, 20 recipients of cells from donors injected with incom- plete Freund's adjuvant alone, and 24 recipients of cells from rats injected with type I collagen in adjuvant. Deliberate addition of solubilized type II collagen to unsensitized cells at the time of transfer or injection of heat-killed sensitized cells also did not cause arthri- tis in a total of 36 recipients. These latter two control groups indicate that disease transfer was not the result ofantigen carry-over. Intravenous injection of sera from arthritic donors was incapable of passively transferring clinical or histologic synovitis in 30 recipients. Thus, these studies directly implicate immunologic sensitiv- ity to the cartilage type of collagen in the etiology of this autoimmune disease.
User-agent based access control for DLNA devices (2014)

DLNA based media sharing is very popular nowadays. In current DLNA specification, a DLNA device advertises its presence to everyone in the network. Any control point application receiving the advertisement can access/control the device. However, with increasing popularity and availability of public Wi-Fi hotspots, it is necessary for devices to have some sort of access control. DLNA specification has no mandatory authentication procedure. So a device receiving a request from any unwanted control point cannot block/verify its access. The UPnP recommended authentication procedure is computationally expensive and complex for most personal devices. So, in this paper we propose a simple User-Agent based access control system that is effective to protect devices from unwanted control point applications.