gebhart/patrepeval huggingface dataset:
Épidémiologie de l’artériolopathie calcifiante urémique au sein d’une cohorte rétrospective régionale de 89 cas et identification des facteurs de risque parmi les patients dialysés (2019)

L’artériopathie calcifiante urémique (ACU) est une maladie rare, entraînant des ulcérations cutanées douloureuses chez les patients à risque en IRC. En l’absence de recommandations, la prise en charge est hétérogène. Nous avons mené une étude de cohorte rétrospective afin de décrire les prises en charge diagnostique et thérapeutique et la survie de l’ACU dans notre inter-région. Les cas d’ACU diagnostiqués entre 2006 et 2016 chez des patients en dialyse et en IRC stade 4 ou 5 non dialysés ont été recensés auprès des néphrologues de notre inter-région et interrogation de la base de données de dialyse MEDIAL. Nous avons sélectionné les patients selon les critères d’Hayashi. Les cas dialysés étaient appariés à deux contrôles hémodialysés, sur l’âge, le sexe, le genre et la région d’appartenance au registre REIN. Quatre-vingt neuf cas ont été identifiés, dont 67 hémodialysés, 3 en DP et 19 en IRC non dialysés. Les cas étaient majoritairement des femmes (64 %), diabétiques (67,4 %), en surpoids ou obèses avec des comorbidités cardiovasculaires. Les troubles de métabolisme osseux liés à l’IRC, l’inflammation et la dénutrition (perte de poids médiane de 3,5 kg, diminution médiane de l’albuminémie de 2,7 g/L) précédaient l’apparition de l’ACU de plusieurs mois. Le traitement incluait le plus fréquemment soins locaux (98,9 %), antibiothérapie (77,5 %), arrêt des AVK (70,8 %) et thiosulfate de sodium intraveineux (65,2 %). Le débridement chirurgical, l’utilisation de chélateurs non calciques du phosphate, une forme distale d’ACU et la localisation aux membres inférieurs étaient associés à une meilleure survie. Les facteurs de risque de développer l’ACU parmi les patients dialysés étaient l’obésité, les AVK, la perte de poids, la diminution de l’albuminémie et l’hyperphosphatémie dans les six mois précédent l’apparition des lésions. Comme dans la littérature, la mortalité était élevée avec 40,4 % des patients étaient décédés à 1 an, majoritairement dans un contexte de soins palliatifs.
Momentum Distribution and Renormalization Factor in Sodium and the Electron Gas (2010)

We present experimental and theoretical results on the momentum distribution and the quasiparticle renormalization factor in sodium. From an x-ray Compton-profile measurement of the valence-electron-momentum density, we derive its discontinuity at the Fermi wave vector. This yields an accurate measure of the renormalization factor that we compare with quantum Monte Carlo and G0W0 calculations performed both on crystalline sodium and on the homogeneous electron gas.
Commissioning of a first-order transition jump in RHIC (2004)

When accelerating gold ions in the Relativistic Heavy Ion Collider (RHIC) the transition energy must be crossed. RHIC uses a set of special quadrupoles and power supplies which can reverse polarity in less than 40 milliseconds. These quadrupoles are used to produce dispersion bumps which increase the transition energy as the beam approaches transition. The change of polarity will then jump the transition energy across the beam energy. This paper describes the commissioning of the RHIC transition crossing system.
A 5.5-GHz Power Amplifier For Wide Bandwidth Polar Modulator (2006)

An efficiency-enhanced power amplifier (PA) is analysed and designed for wide-bandwidth envelope elimination and restoration (EER) system with application to orthogonal frequency-division multiplexing (OFDM) wireless local area network (WLAN) system. The proposed PA has no bandwidth limitation as that of the DC-DC converter used in classical polar modulator. The simulation result shows that the average power-added efficiency (PAE) is 25.38% at a 5.5Ghz average output power of 19dBm with peak to average ratio about 7.7dB and the overall error vector magnitude (EVM) remains less than 10% throughout its output power range. This PA shows much higher PAE among the reported WLAN BiCMOS HBT PAs as well as satisfying IEEE802.11a transmitter back off requirement
Tulp3 is a critical repressor of mouse hedgehog signaling (2009)

Precise regulation of the morphogen sonic hedgehog (Shh) and modulation of the Shh signaling pathway is required for proper specification of cell fate within the developing limbs and neural tube, and resultant tissue morphogenesis. Tulp3 (tubby-like protein 3) is a protein of unknown function which has been implicated in nervous system development through gene knockout studies. We demonstrate here that mice lacking the Tulp3 gene develop abnormalities of both the neural tube and limbs consistent with improper regulation of Shh signaling. Tulp3(-/-) embryos show expansion of Shh target gene expression and display a ventralization of neural progenitor cells in the caudal neural tube. We further show that Tulp3(-/-)/Shh(-/-) compound mutant embryos resemble Tulp3 mutants, and express Shh target genes in the neural tube and limbs which are not expressed in Shh(-/-) embryos. This work uncovers a novel role for Tulp3 as a negative regulatory factor in the Hh pathway.
A Method for Evaluation of Milk "Let-Down" in Lactating Rat. (1957)

A method for evaluation of milk “let-down” in mature lactating rats on 14th day postpartum is described. Amount of milk obtained by litters of 6 young after 30 minutes nursing expressed as percent litter body weight is used as criterion of response. Results obtained follow a normal distribution pattern with a mean value of 3.8 ± .19. The results of this study may serve as a basis for evaluating data from experimental alteration of milk “let-down” in lactating rats.
Stereochemical Insights into the Anaerobic Degradation of 4‐Isopropylbenzoyl‐CoA in the Denitrifying Bacterium Strain pCyN1 (2019)

The constitutions and absolute configurations of two previously unknown intermediates, (1S,2S,4S)-2-hydroxy-4-isopropylcyclohexane-1-carboxylate and (S)-3-isopropylpimelate, of anaerobic degradation of p-cymene in the bacterium Aromatoleum aromaticum pCyN1 are reported. These intermediates (as CoA esters) are involved in the further degradation of 4-isopropylbenzoyl-CoA formed by methyl group hydroxylation and subsequent oxidation of p-cymene. Proteogenomics indicated 4-isopropylbenzoyl-CoA degradation involves (i) a novel member of class I benzoyl-CoA reductase (BCR) as known from Thauera aromatica K172 and (ii) a modified β-oxidation pathway yielding 3-isopropylpimeloyl-CoA analogously to benzoyl-CoA degradation in Rhodopseudomonas palustris. Reference standards of all four diastereoisomers of 2-hydroxy-4-isopropylcyclohexane-1-carboxylate as well as both enantiomers of 3-isopropylpimelate were obtained by stereoselective syntheses via methyl 4-isopropyl-2-oxocyclohexane-1-carboxylate. The stereogenic center carrying the isopropyl group was established using a rhodium-catalyzed asymmetric conjugate addition. X-ray crystallography revealed that the thermodynamically most stable stereoisomer of 2-hydroxy-4-isopropylcyclohexane-1-carboxylate is formed during p-cymene degradation. Our findings imply that the reductive dearomatization of 4-isopropylbenzoyl-CoA by the BCR of A. aromaticum pCyN1 stereospecifically forms (S)-4-isopropyl-1,5-cyclohexadiene-1-carbonyl-CoA.
Mechanistic Studies on the Reaction of Nitroxylcobalamin with Dioxygen: Evidence for Formation of a Peroxynitritocob(III)alamin Intermediate (2013)

Studies by others suggest that the reduced vitamin B12 complex, cob(II)alamin, scavenges nitric oxide to form air-sensitive nitroxylcobalamin (NO(-)-Cbl(III); NOCbl) in vivo. The fate of newly formed NOCbl is not known. A detailed mechanistic investigation of the oxidation of NOCbl by oxygen is presented. Only base-on NOCbl reacts with O2, and the reaction proceeds via an associative mechanism involving a peroxynitritocob(III)alamin intermediate, Co(III)-N(O)OO(-). The intermediate undergoes O-O bond homolysis and ligand isomerization to ultimately yield NO2Cbl and H2OCbl(+)/HOCbl, respectively. Ligand isomerization may potentially occur independent of O-O bond homolysis. Formation of (•)OH and (•)NO2 intermediates from O-O bond homolysis is demonstrated using phenol and tyrosine radical traps and the characterization of small amounts of a corrinoid product with minor modifications to the corrin ring.
A method of testing giving a graphic display of insulation plastic flow information (1965)

Film insulated magnet wires and all plastics, deform, flow away, or even evaporate as a function of heat and pressure. MIL-W-583, its predecessors, several NEMA specifications, and most sales literature describe a cut-through test performed in a well-known manner. Various and numerous burnout tests are also being studied. The tool motor industry has developed burnout tests with actual tools. Unfortunately, with each aforementioned test, a single end point is reached. With this new test, a varying pressure is studied versus a constant temperature, and the resulting data plotted on rectangular co-ordinate. A broader interpretation of plastic flow information is thereby obtained.
Uniform hypertext presentations on the World Wide Web (2002)

Users of the World Wide Web frequently have to access particular documents, for example via FTP or via Wais, that are not ready for managing by http clients using HTML. Such documents not only look poor, but moreover, they don't allow navigation to other sites containing related objects, unless a new request is made. The aim of the paper is to provide a hypertext presentation for those documents that have not been generated with such characteristics. The system we propose, Hypertext Presentation System (HPS), can generate HTML documents on the basis of documents in ASCII format. Its main aim is to provide uniform presentation modalities for semantically similar documents, even if these come from different sources.
Body composition and human sleep (1984)

It has been reported that fit atheletes have more slow wave sleep (SWS), sleep longer and have shorter sleep onset latencies than unfit individuals. However, we have shown that these differences are not a direct consequence of physical fitness. This suggests that the effect is due to more enduring characteristics of individuals. We report two experiments designed to test the hypothesis that individual differences in sleep are related to differences in body composition. The hypothesis was tested in two different experiments, each comparing independent groups of fit athletes with unfit non-athletes. In each experiment both sleep and a number of anthropometric variables were measured. Twenty-five fit and 22 unfit subjects were run in Experiment 1 and 17 fit and 17 unfit in Experiment 2. In Experiment 1 percentage fat was estimated from a skin fold method, while in Experiment 2 lean body mass (LBM) was estimated from 24 h. urinary creatinine. The results showed that percentage LBM was negatively related to SWS in fit subjects, while the amount of LBM and weight were negatively related in the unfit groups. When all subjects were combined within each experiment, significant negative correlations were found between SWS and both LBM and percentage LBM in Experiment 2. The results suggest that body composition influences SWS levels, but not other components of sleep.
The Hunt for the Neurofibromatosis Gene (1991)

The neurofibromatosis type 1 (NF1) gene has been localized to the pericentromeric region of the long arm of chromosome 17. A chronology of events leading to the cloning of the NF1 gene is offered as a summary of modern gene hunting techniques. The gene was identified by its location rather than its function using positional cloning. Linkage analysis, based on DNA polymorphisms, is already available for prenatal and presymptomatic testing. This technique works only in cases when affected family members are available and is useless in spontaneous cases. The complete NF1 gene is huge, has a large number of exons, and is approximately 240,000 base pairs long. Its large size is consistent with the very high spontaneous mutation rate. The NF1 gene is evolutionarily conserved and expressed ubiquitously, not just in neural crest derivatives. Functional and structural homology with GAP (GTP [guanosine triphosphate]ase-activating protein) has been described. The GAP controls (or is controlled by) the ras oncogene. Aberration of ras function, which plays a fundamental role in growth, development, and differentiation, may play a role in the NF1 phenotype. Direct DNA diagnosis of mutations in the NF1 gene in clinical practice is premature. Current data suggest that the NF1 gene product may act as a tumor suppressor.
New Continuous-Time Scheduling Formulation for Continuous Plants under Variable Electricity Cost (2009)

This work addresses the scheduling of continuous plants subject to energy constraints related to time-dependent electricity pricing and availability. Discrete- and continuous-time formulations are presented that can address these issues together with multiple intermediate due dates. Both formulations rely on the resource−task network process representation. Their computational performance is compared for the objective of total electricity minimization with the results favoring the discrete-time model due to the more natural way of handling such a wide variety of discrete events. In particular, it can successfully handle problems of industrial size. Nevertheless, the new continuous-time model is a major breakthrough since it is the first model of its type that is able to effectively incorporate time-variable utility profiles. When compared to a simple manual scheduling procedure, the proposed scheduling approaches can lead to potential electricity savings around 20% by switching production from periods of high to low electricity cost.
[Treatment of hypertriglyceridemia: plasma exchange]. (2013)

Severe hypertriglyceridemia ( >1,000 -2,000 mg/dL) is known to cause acute pancreatitis (AP). If standard treatment regimen including absolute diet restriction regarding fats, use of lipid -lowering agents and combination of low molecular weight heparin with insulin is not effective, plasma exchange (PE) has emerged as an effective modality in rapidly lowering serum triglyceride levels and helping to treat and prevent hypertriglyceridemia-induced AEP. It has been shown to reduce triglyceride levels by an average of 61% after 1 session and provide rapid resolution of AP symptoms. However, the timing of PE in managing hypertriglyceridemia remains unevaluated. Randomized controlled trials on this specific topic are needed to be performed in the future.
Könnyproteomikai és képfeldolgozási technikák alkalmazhatóságának vizsgálata a retinopathia diabetica szűrésében. (2014)

A RD a cukorbetegség egyik leggyakoribb szövődménye, mely az összes vakságban szenvedő személyek 5%-ánál tehető felelőssé az állapot létrejöttéért. Azoknál a 2-es típusú DM-ban szenvedő betegeknél, akiknél a betegség 10 éve fennáll, 80% az esélye, hogy valamilyen fokú RD már kialakult. Mivel a RD kezdetben tünetmentes, a diagnózis időpontjában a betegség sokszor már igen előrehaladott stádiumban van. Időben történő diagnózissal és terápiával a RD progressziója jelentősen lassítható, így a DM-ban szenvedő populáció számára a rendszeres szemészeti szűrővizsgálaton (legalább évente) való részvétel ajánlott. A RD szűrés humánerőforrás igénye, így költségei is igen magasak, ami a szűrés automatizálásával csökkenthető lenne. Jelen munka célja a RD szűrésére alkalmas automatizált eljárás létrehozása. x------------------------------------------------------------------------------------------------------------------------------------- x Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus (DM), accounting for about 5 % of world blindness. Approximately 80 % of all patients with type 2 DM duration of at least 10 years suffer from some degree of DR. During the development of DR, patients may not notice changes of their vision and DR might be very advanced by the time patients have visual complaints and experience visual loss eventually. Timely diagnosis and therapy however can significantly decelerate its progress, necessitating regular DR screening or appropriate follow-up in all patients with DM. Involvement of human graders is currently universal and the less automation is in the screening system the greater the costs. Therefore our aim was to develop a novel automated method for DR screening.
ChemInform Abstract: Syntheses of Various 5‐(3′‐Substituted phenyl)uracils. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Blood coagulation and fibrinolysis before and after exhaustive exercise in patients with IDDM (2003)

Diabetes mellitus involves changes in haemostasis which leads to the opinion that diabetes mellitus is a hypercoagulable state. However, little is known about the relationship of exercise and haemostasis in diabetics. Therefore, first of all the aim was to investigate if differences in blood coagulation and fibrinolysis can be demonstrated in subjects with insulin-dependent diabetes mellitus (IDDM) compared to controls and secondly, if differences concerning exercise induced changes can be seen in diabetics. 16 moderately fit subjects with IDDM and 16 matched controls underwent a maximal step test. Blood samples were taken after a 30 min rest, immediately and 1h after exercise and in addition after 30 min rest 7 days later at the same time of day. The rest values (mean of the two rest samples) in extrinsic total thrombin potential (TTPex, P=0.049), tPA-activity (P=0.007) were significantly higher and in PAI-1-antigen (P=0.002) -activity (P=0.049) lower in the diabetic group. APTT, PT, TAT (only control), TTPin, tPA-activity and -antigen and PAP were increased immediately and D-dimer (only control) 1 h after exercise, whereas PAI-1-activity and -antigen (only control) decreased immediately or 1 h after exercise (all minimal P<0.05). The increase of tPA-antigen and decrease in PAI-1-antigen after exercise were both lower in the diabetics (P<0.05). IDDM led to higher extrinsic total thrombin and fibrinolytic potential at rest, and reducing the exercise provoked distribution of tPA-antigen and decrease of PAI-1-antigen. Nevertheless a higher thrombotic risk after maximal exercise has not been investigated in young IDDM patients without complications and in good metabolic control.
Rheology of Acrylic Bone Cements (1981)

The rheological properties of setting acrylic bone cements were examined with a rotational cone and plate viscometer. The cements were tested over two orders of magnitude of shear rate to determine the nature of any non-Newtonian flow behavior. All three cements behaved with moderate pseudoplasticity (i.e., shear thinning) during setting, suggesting the use of higher pressures during administration for better flow and penetration. The low viscosity brand was found to be nearly one-half as viscous as the conventional cements during the working time (i.e., 2-5 minutes). A series of sieving experiments were performed to determine the particle size distributions of the powder components. Statistical analysis (chi square) showed the cements to have different distributions, with the low viscosity brand containing a larger proportion of smaller polymer particles. This difference is thought to contribute to the lower viscosity of this cement.
DESIGN AND FABRICATION OF A SURFACE CONVERSION NEGATIVE ION SOURCE AND AN 80 keV PRE-ACCELERATOR (1983)

The design and fabrication of a surface conversion negative ion source and an 80 keV pre-accelerator intended for use as a proof-of-principle demonstration leading to a radiation-hardened 400 keV TFF based beamline for the next generation mirror or tokamak reactor will be described in this paper. Experience gained in a previous source and accelerator module was utilized to redefine the overall design and construction for this second generation CW device. The source will provide 1 to 2 amps of H/sup -/ for acceleration by a 3 electrode 80 keV preaccelerator. Particular attention was placed on the mounting of the source to the primary high-voltage insulator, the insulator itself, magnet installation, converter shape and construction, cesium injector and exit aperture design, and accelerator construction, with an overall emphasis on serviceability.
Radical Abstraction of Iodine from Aryl Iodides<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadical Abstraction of Iodine from Aryl Iodides1J. F. Bunnett and Carl C. WamserCite this: J. Am. Chem. Soc. 1966, 88, 23, 5534–5537Publication Date (Print):December 1, 1966Publication History Published online1 May 2002Published inissue 1 December 1966https://pubs.acs.org/doi/10.1021/ja00975a033https://doi.org/10.1021/ja00975a033research-articleACS PublicationsRequest reuse permissionsArticle Views458Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biosynthesis of proteoglycans in cartilage slices. Fractionation by gel chromatography and equilibrium density-gradient centrifugation (1972)

The kinetics of incorporation of [(35)S]sulphate into slices of pig laryngeal cartilage in vitro was linear with time up to 6h. The specific radioactivities of the extracted proteoglycans (containing about 80% of the uronic acid of the cartilage) and the glycosaminoglycans remaining in the tissue after extraction were measured after various times of continuous and ;pulse-chase' radioactivity incorporation. Radioactivity was present in the isolated chondroitin sulphate after 2 min, but there was a 35min delay in its appearance in the extractable proteoglycan fraction. Fractionation of the proteoglycans by gel chromatography showed that the smallest molecules had the highest specific radioactivity, but ;pulse-chase' experiments over 5h did not demonstrate any precursor-product relationships between fractions of different size. Equilibrium density-gradient centrifugation in 4m-guanidine hydrochloride showed that among the proteoglycan fractions the specific radioactivity increased as the chondroitin sulphate content decreased, but with preparations from ;pulse-chase' experiments there was again no evidence for precursor-product relationships between the different fractions. Differences in radioactive incorporation would seem to reflect metabolic heterogeneity within the proteoglycans extracted from cartilage. This may be due either to a partial separation of different types of proteoglycans or to differences in the rates of degradation of the molecules of different size and composition as a result of the nature and specificity of the normal degrading enzymes. The results suggest that molecules of all sizes were formed at the same time.