gebhart/patrepeval huggingface dataset:
Triple sequential grafts using the internal mammary artery. An angiographic and short-term follow-up study. (1992)

Between December 1984 and December 1988, coronary artery bypass operations, involving the use of 119 sequential internal mammary artery grafts with three or more anastomoses per conduit, were performed in 116 patients. Patients included 14 women and 102 men, with a mean age of 60 years. They received a total of 629 anastomoses; 373 anastomoses were used in multiple sequential arterial bypass grafts; 116 sequential left and three right internal mammary artery jump grafts were performed. There were 27 patients with bilateral internal mammary artery grafts, but only 17 had completely arterial revascularizations. Perioperative infarction occurred in 3.4% of the patients; 1.7% of infarctions were related to sequential internal mammary artery grafts. There were no hospital deaths. Control angiography was performed within a month of the operation in 72 patients (with 371 anastomoses, of which 229 were in sequential arterial bypass grafts). The overall patency rate was 94.6%, and for the internal mammary artery sequential graft with three or more anastomoses it was 96.1%. The mean follow-up period was 13 months; 110 patients were in New York Heart Association class I; there was one non-cardiac-related death, and three patients (2.6%) had a late myocardial infarction. One was related to the area revascularized by the sequential internal mammary artery graft. Multiple sequential internal mammary artery bypass grafts in coronary artery disease are feasible, with a high short-term patency and a low perioperative morbidity and mortality.
Colchicine Use in Children and Adolescents With Familial Mediterranean Fever: Literature Review and Consensus Statement (2007)

The daily application of colchicine is the standard therapy for prophylaxis of attacks and amyloid deposition in familial Mediterranean fever. However, because of many issues (eg, dosage, time of introduction, etc), no standardized treatment recommendations have been established. In this work we review the available literature on colchicine use with respect to its indication, efficacy, mode of application, and safety in children and adolescents with familial Mediterranean fever. On the basis of this analysis, a consensus statement on the application of colchicine in children and adolescents with familial Mediterranean fever was developed by caregivers from Germany, Austria, and Turkey.
Salivary, but not serum or urinary levels of progesterone are elevated after topical application of progesterone cream to pre‐and postmenopausal women (2000)

Salivary progesterone measurements confirm that topically applied progesterone is absorbed, despite the lack of change in serum progesterone concentrations. However, at the dose administered, serum progesterone levels do not reach those observed after oral or vaginally delivered progesterone preparations. Higher doses may be required to induce biological responses within the endometrium.
The Glad Hand (1400)

In The Glad Hand a wealthy, communist-hating tycoon named Ritsaat leads a motley gang of explorers through the Bermuda triangle – and the space-time continuum – in pursuit of the antichrist, whom he hopes to lure out into the open for a battle, under the cover of the nineteenth century Cowboy Strike
Comparison of the distribution of <i>Actinomyces</i> in dental plaque on inserted enamel and natural tooth surfaces in periodontal health and disease (1993)

The distribution of Actinomyces naeslundii, Actinomyces viscosus and Actinomyces odontolyticus in healthy and diseased adult populations was studied in 3 different ways. First, supragingival plaque formation at 2 through 72 h was examined in 12 periodontally healthy adults using a removable pre-measured surface of enamel bonded to molars and premolars. Second, a cross-sectional examination of the composition of both supragingival and subgingival plaque of unknown age was conducted in 205 adults exhibiting periodontal health to moderate disease. Third, the effects of oral hygiene instruction and root planing on the subgingival microflora of a subset of 19 subjects with moderate periodontitis were examined. The evaluation of 12 adults revealed that the predominant species in early plaque formation (2, 4 and 8 h) was A. odontolyticus. A. viscosus and A. naeslundii were present in developing plaques in almost all subjects in 2-h plaque, but absent in half the subjects when 4-, 8- or 24-h plaque was examined. These two species significantly increased in numbers per mm2 enamel surface area in 48- and 72-h plaques. A. odontolyticus was not related to clinical signs of periodontal disease in 205 adults, and its subgingival proportions in plaque did not change following periodontal treatment of 19 individuals. A. naeslundii was found in significantly higher numbers in supragingival than subgingival plaques in the 205 adults examined. The mean proportion of A. naeslundii significantly decreased as the magnitude of probing depth and attachment loss increased. The proportions of A. naeslundii and A. viscosus were found to be significantly increased in subgingival plaques following periodontal treatment.
Chemical Nature of Silica Carried by Steam (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical Nature of Silica Carried by SteamEdward L. BradyCite this: J. Phys. Chem. 1953, 57, 7, 706–710Publication Date (Print):July 1, 1953Publication History Published online1 May 2002Published inissue 1 July 1953https://pubs.acs.org/doi/10.1021/j150508a025https://doi.org/10.1021/j150508a025research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Convenient Synthesis of Highly Functionalized Pyrazolines via Mild, Photoactivated 1,3-Dipolar Cycloaddition (2007)

A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regioselectivity, and yield.
Classifier learning with hidden information (2015)

Traditional data-driven classifier learning approaches become limited when the training data is inadequate either in quantity or quality. To address this issue, in this paper we propose to combine hidden information and data to enhance classifier learning. Hidden information represents information that is only available during training but not available during testing. It often exists in many applications yet has not been thoroughly exploited, and existing methods to utilize hidden information are still limited. To this end, we propose two general approaches to exploit different types of hidden information to improve different classifiers. We also extend the proposed methods to deal with incomplete hidden information. Experimental results on different applications demonstrate the effectiveness of the proposed methods for exploiting hidden information and their superior performance to existing methods.
Calcium channel blockers for inhibiting preterm labour; a systematic review of the evidence and a protocol for administration of nifedipine (2003)

Calcium channel blockers (especially nifedipine) can be considered safer and more effective tocolytic agents than betamimetics.
Seis tesis sobre las relaciones entre el Derecho natural y el Derecho positivo (1970)
Feasability of Bacterial Cellulose in Furniture Design (2017)

This research is based on ChemArts Summer Schools (2016) final project “Grow Your Lamp!”, that had great interest and was exhibited in Aalto University`s Learning Centre and as well in Helsinki Design Museum. The study was executed because there is too little knowledge about bacterial cellulose used in furniture design and what could be the strengths and the limitations of the material. Environmental sustainability has posed the need for great development into grown fibres and materials within the interior design industry. This thesis describes and evaluates the feasibility of bacterial cellulose as a possible solution for use in this industry. \n\n\nThe theses will serve as basic information on how to grow and produce the material, as there is little to no information on how to grow it for design purposes. It covers the basic as well as the most important properties of bacterial cellulose as sustainability and biodegradability.\n\n\nAcetobacter xylinum is a cellulose producing bacteria which under the right conditions will self-organise into a nano-structured, textile-like material called bacterial cellulose. The growth period was low in terms of productivity. Less than 1 metre of the fabric could be grown in three weeks. But what the material lacks in economic viability it most definitely makes up in terms of sustainability and biodegradability. \n\n\nThe combination of recyclability, sustainability, biodegradability and new end-use opportunities makes cellulose the potential super material of the future. The use of ethical biomaterials materials impact functionality, aesthetics and ethics of the product.\n\n\nDue to the materials high mechanical strength and leather like appearance, it could be possible to use the material as a part of a seating furniture, as they require this kind of property to carry a weight of average man. The materials stability to endure high temperatures makes it safe to use in lights and even in close contact with light sources. Making it the extremely suitable material when designing lights. This research found out that the limitations of the materials are the low economic viability due to materials long growth period.
Stimulation of Insulin-Like Growth Factor Binding Protein-1 Synthesis by Interleukin-1β: Requirement of the Mitogen-Activated Protein Kinase Pathway<sup>1</sup> (2000)

Insulin-like growth factor (IGF) binding protein-1 (IGFBP-1) is a 28-kDa plasma protein that binds to IGF-I and IGF-II with high affinity. IGFBP-1 is elevated in the blood as a result of sepsis, AIDS, excessive alcohol consumption, and diabetes and may, in part, be responsible for the wasting observed during these pathophysiological conditions. The liver is the principal site of IGFBP-1 synthesis, and we have previously shown that proinflammatory cytokines can directly stimulate IGFBP-1 secretion in a human hepatoma cell line (HepG2). The purpose of the present study was to investigate the role of the MAP kinase pathway in regulating IGFBP-1 synthesis by IL-1beta. We show that IL-1beta stimulates the phosphorylation of ERK-1 and -2 in a time- and dose-dependent manner. In addition, the MAP kinase-kinase MEK-1 and the ribosomal S6-kinase RSK-1 are also phosphorylated in response to IL-1beta. The transcription factor CREB, a potential substrate of both protein kinase A (PKA) and RSK-1, is phosphorylated in response to IL-1beta and cAMP in HepG2 cells. The ability of IL-1beta to stimulate the expression of IGFBP-1 and the phosphorylation of the above kinases was specifically inhibited by PD98059, a MEK-1 inhibitor. cAMP also stimulated IGFBP-1 synthesis, but PD98059 failed to block the cAMP effect. Conversely, a PKA inhibitor (H-89) inhibited the ability of cAMP, but not IL-1beta to stimulate IGFBP-1 synthesis. The effect of IL-1beta and cAMP on IGFBP-1 messenger RNA (mRNA) accumulation was additive. IL-1beta, cAMP, PD98059, and H-89 had similar effects on the accumulation of IGFBP-1 protein and mRNA. IL-1beta and cAMP did not change the half-life of IGFBP-1 mRNA, but PD98059 and SB202190, a p38 MAP kinase inhibitor, destabilized IGFBP-1 mRNA and blocked the phosphorylation of RSK-1 in response to IL-1beta. Our data demonstrate that the MAP kinase signal transduction pathway plays an important role in the regulation of IGFBP-1 synthesis by IL-1beta.
Identification of<i>Cryptosporidium</i>spp. Oocysts in United Kingdom Noncarbonated Natural Mineral Waters and Drinking Waters by Using a Modified Nested PCR-Restriction Fragment Length Polymorphism Assay (2003)

We describe a nested PCR-restriction fragment length polymorphism (RFLP) method for detecting low densities of Cryptosporidium spp. oocysts in natural mineral waters and drinking waters. Oocysts were recovered from seeded 1-liter volumes of mineral water by filtration through polycarbonate membranes and from drinking waters by filtration, immunomagnetizable separation, and filter entrapment, followed by direct extraction of DNA. The DNA was released from polycarbonate filter-entrapped oocysts by disruption in lysis buffer by using 15 cycles of freeze-thawing (1 min in liquid nitrogen and 1 min at 65 degrees C), followed by proteinase K digestion. Amplicons were readily detected from two to five intact oocysts on ethidium bromide-stained gels. DNA extracted from Cryptosporidium parvum oocysts, C. muris (RN 66), C. baileyi (Belgium strain, LB 19), human-derived C. meleagridis, C. felis (DNA from oocysts isolated from a cat), and C. andersoni was used to demonstrate species identity by PCR-RFLP after simultaneous digestion with the restriction enzymes DraI and VspI. Discrimination between C. andersoni and C. muris isolates was confirmed by a separate, subsequent digestion with DdeI. Of 14 drinking water samples tested, 12 were found to be positive by microscopy, 8 were found to be positive by direct PCR, and 14 were found to be positive by using a nested PCR. The Cryptosporidium species detected in these finished water samples was C. parvum genotype 1. This method consistently and routinely detected >5 oocysts per sample.
X-ray characterization of dislocation density asymmetries in heteroepitaxial semiconductors (2008)

We demonstrate an x-ray rocking curve method which allows detection of an asymmetry in the dislocation densities in an heteroepitaxial (001) zinc blende semiconductor layer. These dislocations exist on two types of slip systems with their misfit dislocation line segments oriented along either a [1−10] direction (type A) or a [110] direction (type B). An imbalance in the densities of dislocations on these slip systems produces an observable azimuthal variation in the rocking curve width for symmetric x-ray reflections. An approximate quantitative model allows the estimation of the dislocation densities on the two types of slip systems.
A common mechanism for the enhancement of mRNA 3' processing by U3 sequences in two distantly related lentiviruses (1996)

The protein coding regions of all retroviral pre-mRNAs are flanked by a direct repeat of R-U5 sequences. In many retroviruses, the R-U5 repeat contains a complete core poly(A) site-composed of a highly conserved AAUAAA hexamer and a GU-rich downstream element. A mechanism that allows for the bypass of the 5' core poly(A) site and the exclusive use of the 3' core poly(A) site must therefore exist. In human immunodeficiency virus type 1 (HIV-1), sequences within the U3 region appear to play a key role in poly(A) site selection. U3 sequences are required for efficient 3' processing at the HIV-1 poly(A) site both in vivo and in vitro. These sequences serve to promote the interaction of cleavage and polyadenylation specificity factor (CPSF) with the core poly(A) site. We have now demonstrated the presence of a functionally analogous 3' processing enhancer within the U3 region of a distantly related lentivirus, equine infectious anemia virus (EIAV). U3 sequences enhanced the processing of the EIAV core poly(A) site sevenfold in vitro. The U3 sequences also enhanced the stability of CPSF binding at the core poly(A) site. Optimal processing required the TAR RNA secondary structure that resides within the R region 28 nucleotides upstream of the AAUAAA hexamer. Disruption of TAR reduced processing, while compensatory changes that restored the RNA structure also restored processing to the wild-type level, suggesting a position dependence of the U3-encoded enhancer sequences. Finally, the reciprocal exchange of the EIAV and HIV U3 regions demonstrated the ability of each of these sequences to enhance both 3' processing and the binding of CPSF in the context of the heterologous core poly(A) site. The impact of U3 sequences upon the interaction of CPSF at the core poly(A) site may therefore represent a common strategy for retroviral poly(A) site selection.
Wild‐type murine p53 represses transcription from the murine <i>c</i>‐<i>myc</i> promoter in a human glial cell line (1992)

Here we analyzed the effect of the suppressor proto-oncogene p53 on transcription from the P2 promoter of the murine c-myc gene. c-myc promoter constructs were coupled to the chloramphenicol acetyl-transferase (CAT) gene and were transiently transfected into a human glial cell along with plasmids overexpressing wild-type or mutant p53. It was found that significant repression of c-myc transcription took place following cotransfection with wild-type but not mutant p53. However wild-type p53 did not suppress transcription from the SV40 early promoter or from the MHC promoter. Promoter-CAT constructs containing only the ME1a2 or E2F elements, from the P2 promoter, were repressed by p53, indicating that p53 may exert its effect at these two sites within the P2 promoter. Finally, when the SV40 T antigen and wild-type p53 were expressed together in glial cells the repressive effect of p53 was abolished.
Rehber Materyallerin Öğrencilerin Olayları Nedenleri ile Açıklamaları Üzerine Etkisi: “Madde ve Isı” Örneği (2016)

Bu calismanin amaci, “Madde ve Isi” unitesindeki kavramlarin gunluk hayata transfer edilmesinde derinlestirme asamasina uygun ogrenci ihtiyaclarina yonelik kilavuz hazirlamak ve bu kilavuzun ogrencilerin olaylari nedenleri ile birlikte aciklayabilmelerine yonelik etkisini arastirmaktir. Yari deneysel yontem kullanilarak yurutulen calismada, Madde ve Isi unitesinin derinlestirme asamasina yonelik kilavuz gelistirilmistir. Calismanin orneklemini 67 altinci sinif ogrencisi olusturmaktadir. Veri toplama araci olarak Madde ve Isi unitesi Olaylari Nedenleri ile Aciklama Testinden faydalanilmistir. Deney grubunda derinlesme asamasindaki dersler hazirlanan kilavuz ile yurutulurken; kontrol grubunda ise dersler bu asamada mevcut ders kitabi kullanilarak islenmistir. Yapilan uygulamalar sonrasinda uygulanan kilavuzun deney grubu ogrencilerinin olaylari nedenleri ile aciklamalarinda anlamli bir etkisinin oldugu sonucuna ulasilmistir.
The Physiological Role of Oxygenated Unsaturated Fatty Acids (1988)

The recent extensive studies have demonstrated that the oxygenated unsaturated fatty acids play the important role in both animal and plant kingdoms. This article reviews the physiological activities of the oxygenated fatty acids, showing that the acids act as defensive substances in the living bodies.
Cotransfection with IL-10 and TGF-β1 into immature dendritic cells enhances immune tolerance in a rat liver transplantation model (2014)

Dendritic cells transfected with interleukin (IL)-10 and transforming growth factor-β1 (TGF-β1) enhance T cell immunity and tolerance. However, no quantitative studies have investigated the suppressive functions of immature dendritic cells (imDC) cotransfected with IL-10 and TGF-β1. The effects of imDC cotransfected with IL-10 and TGF-β1 (IL-10-TGF-β1-imDC) on immune tolerance induction in a rat transplantation model were investigated. In addition, effects of IL-10-TGF-β1-imDC relative to IL-10-transfected imDC (IL-10-imDC) and TGF-β1-transfected imDC (TGF-β1-imDC) were compared. The infusion of IL-10-TGF-β1-imDC into recipients prolonged liver graft survival, which was sustained for >90 days. IL-12 serum levels decreased, whereas alanine transaminase and total bilirubin slightly increased in rats infused with IL-10-TGF-β1-imDC compared with the IL-10-imDC and TGF-β1-imDC groups. Furthermore, a higher percentage of terminal transferase-mediated UTP nick end-labeling-positive cells was observed, and histological analysis of the allografts indicated a rejection activity index of mild acute rejection. Our results suggest infusion of IL-10 and TGF-β1 cotransfected imDC induces alloantigen-specific T cell hyporesponsiveness, inhibits antigen-specific immunological responses to liver allografts, prolongs liver allograft survival, and enhances the immune tolerance. This approach may provide a promising alternative for enhancing donor-specific tolerance during liver transplantation.
Pattern association in the brain: amygdala and orbitofrontal cortex (1997)

This chapter examines the location of pattern association neural networks in the brain, their role in the systems-level operation of the brain, and evidence on how they actually operate in the brain. It evaluates evidence suggesting that pattern association is involved in learning associations between sensory representation and reward or punishment and investigates the role of pattern association in backprojections in the cerebral cortex. It also describes pattern association within the hippocampus.
Frequency domain optical reflectometer using a GaAs optoelectronic mixer (1990)

A frequency domain optical reflectometer which uses a GaAs interdigital photodetector both for optical detection and for mixing is described. A simple receiver with a postdetection bandwidth of the order of 10 kHz suffices for distance resolution of 10 m with this technique, greatly simplifying the electronics by comparison with pulsed reflectometers or swept frequency reflectometers employing electronic mixing. With available lasers the instrument could detect discrete optical reflections of -57 dB at a distance of 1 km. It is intended for remote measurement of refractive index in fluids, using the Fresnel reflection from a square-cleaved fiber as the sensor.
Automatic generation of graphical user interfaces for VHDL based controllers (2011)

Recent trends in embedded systems can be categorized by high application sophistication, shorter product life cycles and low cost requirements. As system complexity increases, rapid application development platforms and user interface builders became an important factor to reduce design cost and time-to-market. The tools proposed in this paper enable the rapid development of applications and the respective user interfaces, with automatic VHDL code generation for FPGAs, without requiring the need to write a single line of code. With high processing power, capability to generate graphical images and interface with pointing devices, reconfigurable hardware platforms provide a very competitive solution for embedded systems.