gebhart/patrepeval huggingface dataset:
Statistical Models for Inter- and Intraindividual Variability (1974)

Abstract Data were collected on 60 subjects using a two-treatment, repeated measure design for a blind tracing task and analyzed using various statistical models. The results indicated that appropriate models for estimating the intraindividual response variability included the standard deviation of all trials for each subject, the average of each individual's standard deviation, the adjacent trials correlation coefficient model for repeated trials, and the intraclass reliability for obtained scores model for ANOVA designs. The latter model provides a single score estimate of variability which may be used in interstudy comparisons.
Quantitative Polyacrylamide Gel Electrophoresis of Crystallin and Solubilized Albuminoid Lens Proteins (1974)

Buffer conditions as well as staining and destaining procedures which facilitate a reproducible quantitation of lens proteins in polyacrylamide del electrophoresis (PAGE) were investigated and optimal conditions were chosen. Photopolymerization was found to cause an immobilization of ca 40% of lens proteins in the sample gels. Consequently, PAGE was made with stacking and separating gels only. The dye uptake (Lissamine Green B) to protein ratio was equal for the different proteins in crystallins and solubilized albuminoid. The densitometric recordings of lens proteins within a linear concentration range were resolved into the minimum number of Gaussian distribution functions. These yielded information on the relative content and the mobilities of various lens protein populations. For inbred mouse C57BL lens crystallins a minimum of 26 and for albuminoid a minimum of 20 different proteins were determined. The methods described can be expected to permit a closer insight into lens protein changes with age and disease.
Parasitic Helminths (2012)

Due to the development of resistance to anthelmintics there is a continuous requirement to search for new anthelmintics that act at novel sites. Until now, new anthelmintics have been discovered through screens using parasitic nematodes. However, their mode of action has often been determined through experimental approaches utilizing the free-living nematode, Caenorhabditis elegans. In this chapter, the value of C. elegans as a surrogate parasite will be considered. The phylogenetic relationship between C. elegans and parasitic nematodes suggests that C. elegans may be a preferred model for some parasitic nematodes more than others, being particularly useful for those in the same clade. In this context an important achievement has been the sequencing of the C. elegans genome followed by the genomes of a number of parasitic nematodes. This has enabled the identification of homologous and orthologous genes between C. elegans and parasitic nematodes with two particular experimental advances: (i) the identification of genes in C. elegans that are orthologous to those genes key for normal function in parasitic nematodes and (ii) the expression of parasitic nematode genes in C. elegans to facilitate their functional characterization. Examples of both will be given here. The value of the experimental tractability of C. elegans is weighed against the extent to which it provides a reliable indicator for gene function in parasitic nematodes. Also, we review the value of C. elegans in elucidating the mode of action of anthelmintics with particular reference to anthelmintics acting on nicotinic acetylcholine receptors, glutamate-gated chloride channels, and calcium-activated potassium channels. The examples highlight the use of C. elegans as a model system to identify anthelmintic drug targets. Finally, the potential impact of newer technologies encompassing microfluidics, optogenetics, and imaging on the utility of C. elegans for high-throughput anthelmintic drug discovery is addressed
Analyzing the 24-hour blood pressure and heart-rate variability with self-organizing feature maps (2002)

In this article, the self-organizing map (SOM) is employed to analyze data describing the 24-hour blood pressure and heart-rate variability of human subjects. The number of observations varies widely over different subjects, and therefore a direct statistical analysis of the data is not feasible without extensive pre-processing and interpolation for normalization purposes. The SOM network operates directly on the data set, without any pre-processing, determines several important data set characteristics, and allows their visualization on a two-dimensional plot. The SOM results are very similar to those obtained using classic statistical methods, indicating the effectiveness of the SOM method in accurately extracting the main characteristics from the data set and displaying them in a readily understandable manner. In this article, the relation is studied between the representation of each subject on the SOM, and his blood pressure and pulse-rate measurements. Finally, some indications are included regarding how the SOM can be used by the medical community to assist in diagnosis tasks. © 2002 John Wiley & Sons, Inc.
Preparation of polycrystalline silicon thin films by pulsed ion-beam evaporation (2002)

Summary form only given, as follows. Polycrystalline silicon (poly-Si) thin films are widely used in various electronic devices, such as a semiconductor in thin film transistors (TFTs), solar cells, peripheral circuits of liquid-crystal displays, and electrodes in Si integrated circuits because of its considerably higher carrier mobility compared to that of hydrogenated amorphous silicon thin films. Plasma-enhanced chemical vapor deposition (PECVD) is one of methods to deposit poly-Si films. However, the PECVD has disadvantages because the substrate should be annealed to high temperature (typically, 400 /spl sim/ 1,000 /spl deg/C). The purpose of this study is to prepare poly-Si thin films without heating the substrate by intense, pulsed, ion-beam evaporation (IBE). Using IBE technique, we have succeeded in the preparation of polycrystalline silicon thin films on the substrate of silicon or quartz. High crystallinity has been achieved without annealing. Since the life time of the ablation plasma obtained by the pulsed ion beam with 50 ns pulse width is on the order of 20 /spl mu/s, the instantaneous deposition rate will be /spl sim/1 cm/s. The crystallinity of poly-Si film has been improved with increasing the density of the ablation plasma, while the grain size of the film has been found to be smaller. We will report the characteristics of poly-Si films using X-ray diffraction, Raman spectra, X-ray photoelectron spectroscopy and scanning electron microscope measurements.
Advanced Light Rail Vehicle Communication Systems Design (2004)

The use of electronic subsystems to perform complex tasks has grown in the consumer goods and automotive sectors to such a degree that these capabilities have become commonplace, yet in the field of light rail vehicles, they have made relatively little impact. The technology exists today to provide greatly increased passenger safety, security and system operational efficiency by the judicious application of mature subsystem designs. Such systems include radio based, fully integrated vehicle management systems with GPS, silent alarm capability and passenger information control, external passenger door and coupler monitoring video cameras, forward facing video recording for accident investigations, interior video recording for reduction in vandalism, interior video cameras linked to Passenger to Operator Intercoms to provide the Operator with more information and the transfer of data to and from vehicles via wireless LAN. This paper will describe the application of these subsystems to the new Phoenix light rail vehicle and project what the future may hold.
KNEE-JOINT TEMPERATURE MEASUREMENT USING A DIFFERENTIAL THERMISTOR THERMOMETER (1980)

A simple method for measuring joint inflammation with a differential thermistor probe thermometer was applied to acute synovitis of the knee. Temperature assessments were made immediately before and serially after intra-articular steroid therapy. The method was capable of showing a significant difference in temperature between inflamed and normal knees. Knee temperature assessments correlated well with clinical parameters and were essentially independent of room temperature.
Glyceride Conjugates as Drug Carriers (1995)

Abstract: Drug-lipid conjugates have been prepared in order to confer the attached drugs to the metabolic pathways of natural lipids. The drug can be covalently bound either to a fatty acid or to a glyceride. In glycerides, one or two fatty acid moieties have been replaced by a drug realizing pseudoglycerides. These pseudoglycerides exhibited some physicochemi­ cal properties and absorption characteristics similar to those of natural triglycerides resulting in a different pharmacokinetic and/or pharmacodynamic profile compared that of the parent drug. Non-steroidal anti-inflammatory drugs such as aspirin, indomethacin, ibuprofen, naproxen and aclofenac were covalently bound to diglycerides in order to reduce the ulcerogenicity of the compounds. Employing the absorption process of dietary fat, pseudoglycerides have been used for the targeting of the lymphatic route in order to avoid the first-pass metabolism of a drug (L-DOPA) and I or to target the lymphatic system for the treatment of lymphatic metastasis (chlorambucil, melphalan) or filiariasis (melphalan and GABA). Pseudoglycerides and other glyceride-like structures have been evaluated in order to increase the intestinal absorption of poorly water-soluble drugs such as phenytoin. An improvement of the blood-brain barrier penetration of GABA covalently bound to glycerides has been reported in the 80's, A similar approach was followed for L-dopa, glycine, valproate, and the enkephalinase inhibitor thiorphan including amide bio-isosteres of glycerides. Radioiodinated agents containing fluoride and nitroxyl moieties were coupled to glycerides and fatty acids as potential hepatographic agents in nuclear medicine, 19F- and 1H-nuclear magnetic resonance imaging, respectively. A variety of phospholipid-linked cytotoxic nucleosides and nucleoside analogues such as ara-C, AZT and acyclovir have been prepared. Compared to the parent drugs the phospholipid analogs exhibited increased antineoplastic activity in vitro and in vivo. The conjugates were also active against tumors and viruses that were resistant against the drug itself.
Bulletin No. 1 : September 25, 1931 / (1931)

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Impact of vertical RRAM device characteristics on 3D cross-point array design (2014)

Resistive switching random access memory (RRAM) is one of the most promising candidates for the next-generation non-volatile memory. To enable large capacity RRAM array, the 3D architecture is needed. In this work, the analyses of different device characteristics, including the RRAM ON/OFF-state resistance (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> /R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> ), I-V nonlinearity ratio and the interconnect material, are performed to find the optimal design point of the 3D RRAM array. The results show that insufficient current drivability of the vertical transistor causes a significant amount of voltage drop on the transistor. The write and read margin conflicts with each other. A high R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> is preferred over a high nonlinearity to improve the write/read margin. A RRAM cell with R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> =500kΩ and nonlinearity=5x can satisfy the specified programming and read sense criterion for a 128×128×16 array, Moreover, the energy consumption (<;nJ/bit) of the write operation outperforms that in NAND FLASH. Finally, a feature size (F) of 30nm and 60nm with equal array densities are compared, which suggests that the downscaling of feature size might not be as crucial as believed and the design constraint can be relaxed as a result.
Automatic Statistical Processing of Multibeam Echosounder Data (2003)

This paper presents the CUBE (Combined Uncertainty and Bathymetry Estimator) algorithm. Our aim is to take advantage of statistical redundancy in dense Multibeam Echosounder data to identify outliers while tracking the uncertainty associated with the estimates that we make of the true depth in the survey area. We recognise that a completely automatic system is improbable, but propose that significant benefits can still be had if we can automatically process good quality data, and highlight areas that probably need further attention. We outline CUBE and its associated support structures, and apply it to a dataset from Woods Hole, MA, USA. We illustrate CUBE'S output surfaces, show that the algorithm faithfully maintains significant bathymetric detail, and how the algorithm's auxiliary outputs can be used in the decision-making process. Comparison with a selected sounding set shows that CUBE’S outputs agree very well with traditional approaches.
Synergistic enhancement of the bleomycin and peplomycin induced mitotic index reduction by verapamil. (1985)

The cytostatics bleomycin and peplomycin are known to reduce the mitotic index. It is shown that in cultured human lymphocytes the heart drug verapamil (Isoptin) increases this effect synergistically. This seems to be for the first time that synergism in the reduction of the mitotic index by chemical agents has been demonstrated.
Theoretical and experimental study on the tubular indirect evaporative cooler. (2006)

The authors investigated the characteristics of indirect evaporative cooling air conditioners, including absorbing water materials, heat exchanger configuration, supplying water ways. Three innovative ways to intensify translating heat, namely functional fiber cover, ellipse-type aluminium foil tube, intermittent water supply, and the optimizing of the configuration of the tube type, emerged.
A Study of Neural Matching Models for Cross-lingual IR (2020)

In this study, we investigate interaction-based neural matching models for ad-hoc cross-lingual information retrieval (CLIR) using cross-lingual word embeddings (CLWEs). With experiments conducted on the CLEF collection over four language pairs, we evaluate and provide insight into different neural model architectures, different ways to represent query-document interactions and word-pair similarity distributions in CLIR. This study paves the way for learning an end-to-end CLIR system using CLWEs.
The Pilot Survey of the Industry 4.0 Principles Penetration in the Selected Czech and Polish Companies (2016)

The article deals with the aspects of the ICT innovation based on the development of the internet of things in industrial branches. This trend is known as the Industry 4.0, e.g. the forth industrial revolution. The article presents main results of the pilot survey done in selected Czech and Polish companies. They show the current status of the Industry 4.0 understanding and penetration in companies, incl. expected benefits and known obstacles of this trend.
Identity or Condition: The Theory and Practice of Applying State Disability Laws to Transgender Individuals (2019)

Jean Doe was a 17-year-old transgender youth when she brought suit against the New York City Administration for Children’s Services in New York Supreme Court. She had been in and out of foster homes since the age of nine, and had a troubled history of “violent altercations” in many of the foster homes in which she had been placed throughout these years. Her latest placement was in the Atlantic Transitional Foster Facility, an all-male facility for short-term placement of foster children who are in the care of New York City’s Administration for Children’s Services. Upon her arrival at Atlantic Transitional, the director of the facility expressly prohibited her from expressing her gender identity by wearing “female attire,” although she still could wear “scarves, ‘nails,’ brassieres, and enhancers.” When Jean Doe moved for a preliminary injunction, Atlantic Transitional tried to avoid liability by broadening its policy’s reach to the rest of the facility, forbidding all residents from wearing skirts or dresses. Undeterred, Doe brought a lawsuit against the facility, alleging gender discrimination, violations of her First Amendment to free expression, and disability discrimination. The court ultimately found for Doe solely on the disability discrimination claim and mentioned nothing about the other two claims in its opinion. Doe v. Bell is illustrative of the difficulties transgender advocates have had in bringing gender discrimination claims on behalf of their clients, as well as their relative success in using state disability anti-discrimination laws to garner protection for their clients. Cases that recognize gender discrimination laws as inclusive of transgender individuals, have changed the legal landscape for transgender individuals, such as the recent D.C. Circuit case of Schroer v. Billington, which held that a transgender plaintiff had been discriminated against in employment on the basis of sex under Title VII of the 1964 Civil Rights Act. In many cases over the past two decades, advocates have demonstrated the efficacy of state disability anti- discrimination claims as applied to transgender individuals. Although federal law expressly excludes transgender individuals from the protected class of persons with disabilities, many states do not follow suit. Moreover, at least one State court used the federal exclusion to show that the absence of this exclusion in that State’s disability laws clearly demonstrated the State legislature’s intent to actively include transgender individuals under these laws.
Selective modulation of scleral proteoglycan mRNA levels during minus lens compensation and recovery. (2007)

These data suggest that the expression of aggrecan is strongly differentially modulated in the sclera during experimentally induced myopia and recovery. The modulation of aggrecan in concert with previously described changes in type I collagen and hyaluronan may play a key functional role in modulating the ability of the lamellae to slip across one another. This may be manifested in the scleral creep rate, which in turn modulates axial elongation rate and refractive state.
Human monoclonal antibody to purified protein derivative of tuberculin produced by hybrids constructed with Epstein‐Barr virus‐transformed B lymphocytes and mouse myeloma cells (1986)

A method of producing human monoclonal antibody by combining somatic cell hybridization technology with the capability of Epstein-Barr virus (EBV) to transform human B lymphocytes is described. Peripheral blood lymphocytes from a donor with positive tuberculin skin test reaction were transformed by EBV and then tested for antibody production to mycobacterial purified protein derivative (PPD) by an enzyme-linked immunosorbent assay. Two EBV-transformed lymphoblastoid cell lines making IgM antibodies to PPD were obtained. One of these cell lines was fused by polyethylene glycol with a murine hypoxanthine-guanine phosphoribosyl transferase-deficient myeloma cell line that had been selected for resistance to ouabain. The human-mouse hybrids were selected in ouabain-containing HAT medium and 11 heterohybridomas producing IgM antibody to PPD were obtained. One of these was cloned by limiting dilution with efficiency at least 20-fold higher than parent EBV-transformed cell line. Heterohybridoma subclones reached levels of IgM antibody as high as 75.0 micrograms/ml of culture medium, whereas IgM production of EBV-transformed B cell clones ranged between 3.0 and 4.0 micrograms/ml.
The guarantee of QoS for wireless multimedia streams based on adaptive session (2002)

The guarantee of quality of service (QoS) is a key issue for multimedia streams in wireless multimedia communications. QoS parameters required by most of multimedia streams are ranges or in set, [QoS/sub min/, QoS/sub max/]. Computer systems and network systems must allocate enough resources such as CPU, I/O, memory and bandwidth to meet these QoS parameters. These resources are dynamic variations in availability, e.g., bandwidth on radio during multimedia stream transmission. The adaptive session is defined to formularize multimedia stream. It can allocate resources with QoS/sub min/, during establishment of a multimedia stream call and it can dynamically adjust its QoS parameters in [QoS/sub min/, QoS/sub max/] by PID to adapt the variations in resource availability during multimedia transmission. It not only meets the QoS parameters required, but also improves the useful of resources.
New species of Diptera (1921)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Implementing a Competitive Bidding Program for Electric Power Supply (1991)

The Public Utility Regulatory Policies Act of 1978 (PURPA) began a series of events that has shaped the current restructuring of the electric utility industry and the way the industry is regulated. While the primary intent was to conserve energy, it also had the effect of encouraging alternative sources of generation beyond the original intent. Initially, all public utility commissions required utilities to pay PURPA-qualified facilities (QFs) an administratively determined avoided-cost rate. Increasingly, however, many commissions and utilities are turning to competitive bidding to determine a rate for purchased power. A survey of March 1990 found competitive bidding programs operating in twenty-six states. The competitive bidding process has five stages: solicitation, evaluation, selection, negotiation, and contracting. Designing a competitive bidding program for power supply requires the public utility commission and/or utility to consider many interdependent elements that occur in each of these stages. Four legal issues concern the negotiating and contracting stages of bidding and many state commissions lack the authority to solve them. (1) Legal issue concerns transmission access. Lack of access may limit the economic advantages to be gained from bidding. (2) The current structures of the Public Utility Holding Company Act of l935 (PUHCA) may retard development of an independent power production industry because potential owners do not want to assume the legal requirements of the PUHCA. (3) Competitive bidding affects the siting and certification-of-need procedures of state commissions. (4) State/federal jurisdictional conflicts can arise because of competitive bidding, since FERC has exclusive jurisdiction to set wholesale power rates. A competitive bidding program should be a joint product of state and federal regulators, utilities, consumer groups, nonutility generators, and other interested parties.
Navigation control for an exploration rover with microwave Doppler sensors (Fabrication of third prototype rover and experiments) (2014)

Microwave Doppler sensors commonly used in automatic-door systems have been used in a rover navigation system. A collimated microwave beam with an angular width of ±3° at a frequency of 24 GHz was emitted from a sensor (A) on a dish antenna 30 cm in diameter. Another sensor (B), which works as a detector, was installed on the rover. The rover was programmed to make a right turn when the microwave signal was above a specified level and to make a left turn when the signal was than that level. In this study, we fabricated the third prototype rover. To confirm the effectiveness of the proposed method, we performed the experiments on the strength distribution of the microwave beam, and on the navigation control with the fabricated rover..
Watchdog (1988)

Q I have specialist nursing qualifications, and I feel that I am being pressurised by my employer into accepting redundancy or agreeing to work in aged care.