gebhart/patrepeval huggingface dataset:
Adhesion and biofilm formation on polystyrene by drinking water-isolated bacteria (2010)

This study was performed in order to characterize the relationship between adhesion and biofilm formation abilities of drinking water-isolated bacteria (Acinetobacter calcoaceticus, Burkholderia cepacia, Methylobacterium sp., Mycobacterium mucogenicum, Sphingomonas capsulata and Staphylococcus sp.). Adhesion was assessed by two distinct methods: thermodynamic prediction of adhesion potential by quantifying hydrophobicity and the free energy of adhesion; and by microtiter plate assays. Biofilms were developed in microtiter plates for 24, 48 and 72 h. Polystyrene (PS) was used as adhesion substratum. The tested bacteria had negative surface charge and were hydrophilic. PS had negative surface charge and was hydrophobic. The free energy of adhesion between the bacteria and PS was > 0 mJ/m(2) (thermodynamic unfavorable adhesion). The thermodynamic approach was inappropriate for modelling adhesion of the tested drinking water bacteria, underestimating adhesion to PS. Only three (B. cepacia, Sph. capsulata and Staphylococcus sp.) of the six bacteria were non-adherent to PS. A. calcoaceticus, Methylobacterium sp. and M. mucogenicum were weakly adherent. This adhesion ability was correlated with the biofilm formation ability when comparing with the results of 24 h aged biofilms. Methylobacterium sp. and M. mucogenicum formed large biofilm amounts, regardless the biofilm age. Given time, all the bacteria formed biofilms; even those non-adherents produced large amounts of matured (72 h aged) biofilms. The overall results indicate that initial adhesion did not predict the ability of the tested drinking water-isolated bacteria to form a mature biofilm, suggesting that other events such as phenotypic and genetic switching during biofilm development and the production of extracellular polymeric substances (EPS), may play a significant role on biofilm formation and differentiation. This understanding of the relationship between adhesion and biofilm formation is important for the development of control strategies efficient in the early stages of biofilm development.
René Robin. — Parthenay, étude de géographie urbaine. (1959)

Robert Jean. René Robin. — Parthenay, étude de géographie urbaine.. In: Norois, n°23, Juillet-Septembre 1959. pp. 317-320.
Le developpement des services nationaux de recherche agricole : l'experience de l'Inde avec la Fondation Rockefeller et les lecons que l'Afrique pourrait en tirer (1986)

By drawing on the diaries of scientists in the Rockefeller Foundation who assisted India in developing its research system in the 1950s and 60s, this paper outlines the process by which research reorganization was achieved and the external factors which induced the reorganization. The paper also discusses this reorganization in relation to the growth in productivity of the Indian system and the role that the Foundation played in that process. It stresses that external factors may frequently be critical in developing coalitions of elite needed for policy reform. It nevertheless contrasts the experience of the Rockefeller Foundation in India with that of the donors currently attempting to build the same systems in Africa. It stresses the preconditions needed to achieve a successful donor recipient collaboration in both donor and recipient countries including the need for a long term perspective, political support at the highest levels of the government, the quality and the length of service of the donor and recipient scientists and a wholistic approach to organizational improvement which simultaneously addresses the problems of human capital, institutions, incentives and administrative procedures.
Anterior cruciate reconstruction in the chronically unstable knee using an expanded polytetrafluoroethylene (PTFE) prosthetic ligament (1987)

The purpose of this study is to review 30 patients with failed, multiply operated knees, or knees with gross instability which were reconstructed using the expanded polytetrafluoroethylene (PTFE) prosthetic ligament as a substitute for the ACL. The results were then compared with our experience with the proplast ligament used in a previous clinical series. This prospective review evaluated the patients preoperatively and at regular intervals during the postoperative period. The average followup was 24 months postoperation. Eighty-three percent of the patients had a satisfactory result, scoring greater than 140 points on a 200 point knee grading scale. Objectively, the anterior instability pattern was improved in 87% of the knees. Subjectively, pain of at least a mild degree persisted in 70% of the patients postoperatively. This pain seemed to correlate with articular cartilage changes documented intraoperatively. Major complications occurred in two patients. In conclusion, the PTFE prosthetic ligament was an improvement over the proplast ligament in the reconstruction of the multiply operated, unstable knee. The 83% satisfactory rate with the PTFE was promising compared to a 52% satisfactory rate using the proplast ligament. However, we encourage future long term studies of the PTFE prosthetic ligament in the reconstruction of the ACL in the chronically unstable knee.
Biological Performance Of Materials - Fundamentals Of Biocompatibility (1992)

Part 1 General considerations: biocompatability - definitions and issues introduction to the biological environment. Part 2 Material response - function and degradation of materials in vivo: swelling and leaching corrosion and dissolution reactions of biological molecules with biomaterial surfaces mechanics of materials - deformation and failure friction and wear implant materials - properties. Part 3 Host response - biological effects of implants: the inflammatory process coagulation and haemolysis adaptation allergic foreign-body response chemical and foreign-body carcinogenesis mineral metabolism systemic distribution and excretion effects of degradation products on remote organ functions diagnosis of host response. Part 4 Methods of test for biological performance: in vitro test methods in vivo implant models qualification of implant materials standardization and regulation of implant materials design and selection of implant materials.
Serum IgD and IgE concentrations in immunodeficiency diseases. (1975)

Concentrations of IgD and IgE were measured in sera from 165 patients with well-defined immunodeficiency in an effort to find information possibly relevant to the roles of antibodies of these classes in host defense. Values for both immunoglobulins were generally quite low in patients who had marked deficiencies of all three major immunoglobulins, although occasional normal or high normal values for IgD were seen in hypogammaglobulinemic patients. Group mean IgD concentrations were also depressed in patients with Wiskott-Aldrich syndrome and in those with selective IgA deficiency; IgE concentrations were depressed in patients with X-linked immunodeficiency with hyper-IgM and in those with ataxia telangiectasia. IgD and IgE were both significantly elevated in patients with extreme hyperimmunoglobulinemia E and undue susceptibility to infection and in a patient with the Nezelof syndrome; none of these patients had histories suggestive of atopy. In addition, the mean IgE concentration was significantly elevated in patients with selective IgA deficiency, many of whom were atopic, and in those with the Wiskott-Aldrich syndrome. The highest IgD concentration (163 mg/100 ml) was found in serum from a boy with variable immunodeficiency who had a lifelong history of severe recurrent pharyngeal infections, primarily streptococcal in etiology. Recurrent staphylococcal infection was a feature common to many but not all patients with elevated serum IgE concentration. These data may prove useful in the future delineation of biologic roles for antibodies in these two immunoglobulin classes.
Myofibroblasts in the Infarct Area: Concepts and Challenges (2012)

Myofibroblasts are differentiated fibroblasts that hold a key role in wound healing and remodeling following myocardial infarction (MI). A large repertoire of stimuli, such as mechanical stretch, growth factors, cytokines, and vasoactive peptides, induces myofibroblast differentiation. Myofibroblasts are responsible for the production and deposition of collagen, leading to the establishment of a dense extracellular matrix that strengthens the infarcted tissue and minimizes dilatation of the infarct area. In addition, cells contributing to fibrosis act on sites distal from the infarct area and promote collagen deposition in noninfarcted tissue, thus contributing to adverse remodeling and consequently to the development of congestive heart failure (CHF). Current drugs that are used to treat post-MI CHF do influence fibroblasts and myofibroblasts; however, their therapeutic efficacy is far from being regarded as ideal. Novel therapeutic agents targeting (myo)fibroblasts are being developed to successfully prevent the cardiac remodeling of sites remote from the infarct area and therefore hinder the establishment of CHF. The purpose of this review article is to discuss the basic concepts of the myofibroblasts' actions in cardiac wound healing processes, factors that influence them, currently available pharmacological agents, and future challenges in this area.
Calcified macroalgae – critical to coastal ecosystems and vulnerable to change: a review (2009)

Calcified macroalgae are distributed in marine habitats from polar to tropical latitudes and from intertidal shores to the deepest reaches of the euphotic zone. These algae play critical ecological roles including being key to a range of invertebrate recruitment processes, functioning as autogenic ecosystem engineers through provision of three-dimensional habitat structure, as well as contributing critical structural strength in coral reef ecosystems. Calcified macroalgae contribute significantly to the deposition of carbonates in coastal environments. These organisms are vulnerable to human-induced changes resulting from land and coastal development, such as altered patterns of sedimentation, nutrient enrichment through sewage and agricultural run-off, and are affected by coastal dredging and aquaculture. The consequences of increasing sea surface temperatures and fundamental changes in the carbon chemistry of seawater due to CO2 emissions from anthropogenic activities will have serious impacts on calcifying macroalgae. It is not yet understood how interactions between a range of variables acting at local and global scales will influence the viability of calcifying macroalgae and associated ecosystems. Research is urgently needed on all aspects of the taxonomy, biology and functional ecology of calcifying macroalgae. Without an understanding of the species present, measurement of change and understanding species-specific responses will not be possible.
Robust Location-Aware Activity Recognition Using Wireless Sensor Network in an Attentive Home (2009)

This paper presents a robust location-aware activity recognition approach for establishing ambient intelligence applications in a smart home. With observations from a variety of multimodal and unobtrusive wireless sensors seamlessly integrated into ambient-intelligence compliant objects (AICOs), the approach infers a single resident's interleaved activities by utilizing a generalized and enhanced Bayesian Network fusion engine with inputs from a set of the most informative features. These features are collected by ranking their usefulness in estimating activities of interest. Additionally, each feature reckons its corresponding reliability to control its contribution in cases of possible device failure, therefore making the system more tolerant to inevitable device failure or interference commonly encountered in a wireless sensor network, and thus improving overall robustness. This work is part of an interdisciplinary Attentive Home pilot project with the goal of fulfilling real human needs by utilizing context-aware attentive services. We have also created a novel application called ldquoActivity Maprdquo to graphically display ambient-intelligence-related contextual information gathered from both humans and the environment in a more convenient and user-accessible way. All experiments were conducted in an instrumented living lab and their results demonstrate the effectiveness of the system.
Wolman's disease: a review of treatment with bone marrow transplantation and considerations for the future. (1992)

Wolman's disease is a fatal disorder characterized by absence of acid lipase and accumulation of cholesterol esters. Inanition due to malabsorption and intractable diarrhea has been the most prominent cause of early demise within the first year. Further complications have included cirrhosis and pulmonary failure due to cholesterol ester storage in respective cells. Although sustained caloric balance can be maintained by total parenteral nutrition, this has not altered the eventual course of disease. The acid lipase deficiency in leucocytes in Wolman's disease can be corrected subsequent to bone marrow transplantation. This has proven to be the case in two patients so transplanted. In two other patients, engraftment was not obtained following bone marrow transplantation. The concept of treatment of Wolman's disease by providing normalization of the acid lipase activity by allogeneic bone marrow transplantation remains valid. However, improvement of bone marrow transplant procedure needs to be implemented since pre-existing morbid pathology enhances toxicity and may prevent engraftment. Alternative modifications for accomplishing sustained engraftment without toxicity need to be examined. Other potential therapies need to be inspected in treatment of patients with Wolman's disease. The capability of reducing cellular cholesterol synthesis by use of lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, is now available. In the future, isolation and purification of acid lipase will allow for direct infusion of missing enzyme. The molecular biology now known concerning acid lipase gene holds promise for the future for recombinant manufacturing of acid lipase. And, gene therapy with its use of autologous bone marrow transplantation will be tried in future.(ABSTRACT TRUNCATED AT 250 WORDS)
Test criteria for context-free grammars (2004)

This paper discusses the formalization of the test adequacy criterion for context-free grammars. The basic concept of grammar-based testing is introduced and the grammar-based test criterion is formally defined. This paper also proposes a family of grammar-based structural test criteria whose subsume relations and test set sizes are analyzed, which are used to assess the proposed criteria. Some basic properties based on Weyuker's axiom systems are generalized and some fundamental properties specific to grammar-based testing are proposed We believe the concepts developed in this paper will contribute to the classical theory of software testing adequacy and are very valuable for software test practice
Decision analysis of tamoxifen for the prevention of invasive breast cancer. (2000)

Tamoxifen use may improve long-term survival and quality-adjusted survival among women who are at increased risk of breast cancer, but this benefit diminishes with age. Tamoxifen is cost-effective in comparison with other cancer treatment strategies for younger women only.
Gigabit-density magnetic recording (1993)

A tutorial on the principles of magnetic recording is given. The enormous rate of areal density increase for the past thirty years as well as the principal technological changes behind such sustained progress are outlined. The general issues involved in gigabit-density recording and the features that are common to both IBM'S and Hitachi's gigabit efforts are explored. The principal recording components, namely, the recording head and the medium, are considered, focusing on the problems encountered in designing, optimizing, and realizing them for gigabit-density applications. The performance of gigabit recording configurations from both IBM and Hitachi is reviewed. The performance limitations of these gigabit configurations and the prospects for further areal density extensions in magnetic recording are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optimal battery energy storage system (BESS) charge scheduling with dynamic programming (1995)

A dynamic programming algorithm for the optimal charge/discharge scheduling of BESS energy storage is presented. It ensures the minimisation of the electricity bill for a given battery capacity, while reducing stress on the battery and prolonging battery life. Optimal scheduling of the battery charge state is in itself unique; the methods of multipass dynamic programming are used to accomplish this. Maximum payoff for load redistribution and peak load shaving is determined while accounting for charging rate, battery voltage fluctuation and internal losses as a function of charge state. The optimal charging curve is significantly different from the curve conventionally published for BESS.
Analgesic properties of loperamide differ following systemic and local administration to rats after spinal nerve injury (2012)

These findings suggest that both systemic and local administration of loperamide induce an opioid receptor-dependent inhibition of heat and mechanical hyperalgesia in nerve-injured rats, but that local paw administration of loperamide also induces thermal and mechanical antinociception.
Relationship between the Supply of Primordial Follicles and the Onset of Follicular Growth in Rats1 (1994)

Primordial follicles enter a state of suspended animation when they are formed and constitute a "stockpile" from which all growing follicles are derived. The factors that release individual follicles from their quiescent state are unknown. Many investigators believe that the number of follicles in the primordial stockpile is a major factor in determining the rate at which follicles begin to grow. However, the relationship between the size of the stockpile of primordial follicles and the rate at which follicles move into the growing pool is unclear. The purpose of the present study was to attempt to clarify this relationship. The initial size of the stockpile of primordial follicles was experimentally reduced by exposing rats to various doses of busulphan (BUS) in utero. Ovaries were collected at various ages postpartum and prepared for histological analysis. A computer-controlled image analyzer was used to perform size/frequency analysis of oocytes in control and treated ovaries; onset of follicular growth was recognized by enlargement of the oocyte. There was an inverse correlation between the number of primordial follicles in the ovary at birth and the rate at which they moved into the growing pool. In rats most severely affected by the BUS, all of the remaining follicles began to grow very early in life. By the time these severely affected rats reached adulthood, the stockpile of primordial follicles had been nearly exhausted. Nevertheless, the number of large antral follicles remained at normal levels until the follicular reserve was completely depleted.(ABSTRACT TRUNCATED AT 250 WORDS)
Murine Oncogenicity and Pharmacokinetics Studies of 9-<i>cis</i>-UAB30, an RXR Agonist, for Breast Cancer Chemoprevention (2010)

The synthetic retinoic acid analog, 9-cis-UAB30 [(2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid], is a specific ligand for the retinoid X receptor. Murine oncogenicity and pharmacokinetics studies were performed as part of the preclinical development of 9-cis-UAB30 for breast cancer chemoprevention. In the oncogenicity study, TSG-p53((+/-)) (p53 knockout) mice (25 per sex per group) received daily gavage exposure to 9-cis-UAB30 doses of 0 (control), 30, 100, or 300 mg/kg/d for 6 months. Positive controls received p-cresidine (400 mg/kg/d) for 6 months. 9-cis-UAB30 had no biologically significant effects on survival, body weight, body weight gain, clinical signs, hematology, or clinical chemistry but induced dose-related hepatomegaly in both sexes and decreased thymus weights in high-dose females. Gross and microscopic pathology provided no evidence of 9-cis-UAB30 toxicity or oncogenicity; by contrast, p-cresidine induced urinary bladder neoplasms in more than 60% of male and female mice. It was concluded that 9-cis-UAB30 is not oncogenic in p53((+/-)) mice. In the pharmacokinetics study, C57BL/6 mice received daily gavage exposure to 9-cis-UAB30 (100 or 300 mg/kg/d) for 1 or 7 days. Pharmacokinetic parameters were similar after 1 and 7 days of dosing. Dose-related peak plasma levels of 9-cis-UAB30 were seen between 0.25 and 3 hours; volume of distribution was comparable at both dose levels. Increases in area under the curve were less than proportional to dose and were associated with an increased rate of apparent clearance and decreased elimination half-life. These results suggest decreased absorption and/or possible induction of clearance mechanisms. Enzyme induction may underlie the hepatomegaly seen in mice treated with 9-cis-UAB30 for 6 months in the oncogenicity study.
Relationship between Initial Vancomycin Concentration‐Time Profile and Nephrotoxicity among Hospitalized Patients (2009)

The results indicate that a vancomycin exposure-toxicity response relationship exists. The vancomycin trough value is the pharmacodynamic index that best describes this association.
A convergence of Western marketing mix concepts and oriental strategic thinking (Конвергенция западной смеси маркетинговых концепций и восточного стратегического мышления) (1995)

The mundane and expanded marketing mix concept has an important role in Western marketing literature for both tangible products and intangible services. The nine Ps - namely promotion, product, price, place, process management, personnel, physical facilities, public relations and power - are now the foundation for strategic planning in many companies. While the marketing mix concept remains an important framework for the Western world, its contribution towards the latter's declining economic prowess in recent years appears minimal. On the other hand, the East Asian economic powerhouse has grown from strength to strength. This can be attributed in no small way to certain oriental traditions and philosophies - not the least of which is Sun Tzu's The Art of War. Although The Art of War is now more than 2,000 years old, it remains the cornerstone for strategic planning in the East. Attempts to integrate the Western marketing mix concept with The Art of War from the East using examples drawn from the construction industry in Singapore. The lessons to be learned therefore should be useful for strategic planners in the Western marketing community.
El rol político de las clases medias en América Latina (1980)

En virtud de las limitaciones de espacio propias de un articulo, nos remitiremos a analizar las modificaciones fundamentales acaecidas en los sectores medios y al como tales modificaciones proponen nuevas actitudes politicas. Por otra parte, circunscribiremos nuestro enfoque a los problemas que los sectores medios significan para el proyecto socialista.