Isoproterenol for the Treatment of Circulatory Shock (1969)

Editorials1 March 1969Isoproterenol for the Treatment of Circulatory ShockMAX HARRY WEIL, M.D., PH.D., F.A.C.P., HERBERT SHUBIN, M.D., F.A.C.P.MAX HARRY WEIL, M.D., PH.D., F.A.C.P.Search for more papers by this author, HERBERT SHUBIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-3-638 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLimitation in cardiac competence as a determinant of survival after the onset of circulatory shock has been the subject of important experimental and clinical studies in recent years (1-3). A fundamental although not exclusive defect in shock due to various causes is a significant reduction in cardiac output. Yet when shock occurs in patients who have hepatic cirrhosis or generalized peritonitis, large arteriovenous shunts often account for normal or even increased cardiac output values (4, 5). The portion of the cardiac output that bypasses the capillary exchange circuit does not serve metabolic needs. If the portion available for tissue perfusion...References1. CROWELLGUYTON JWAC: Further evidence favoring cardiac mechanism in irreversible hemorrhagic shock. Amer. J. Physiol. 203: 248, 1962. CrossrefMedlineGoogle Scholar2. ROTHESELKURT CFEE: Cardiac and peripheral failure in hemorrhagic shock in the dog. Amer. J. Physiol. 207: 203, 1964. CrossrefMedlineGoogle Scholar3. CAREYBROWNMOHRMONSONYAOSHOEMAKER JSRSPADOSTWC: Cardiovascular function in shock: responses to volume loading and isoproterenol infusion. Circulation 35: 327, 1967. CrossrefMedlineGoogle Scholar4. UDHOJIWEIL VNMH: Hemodynamic and metabolic studies on shock associated with bacteremia: observations on sixteen patients. Ann. 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MedlineGoogle Scholar17. GUNNARLOCHPIETRASTOBIN RMHSRJJR: Ineffectiveness of isoproterenol in shock due to acute myocardial infarction. JAMA 202: 1124, 1967. CrossrefMedlineGoogle Scholar18. WEILBRADLEYSHUBIN MHECH: Unpublished observations. Google Scholar19. COHENELLIOTKLEINGORLIN LSWCMDR: Coronary heart disease: clinical, cinearteriographic and metabolic correlations. Amer. J. Cardiol. 17: 153, 1966. CrossrefMedlineGoogle Scholar20. KENNEDYBAILAS JHN: Support of the failing circulation: effects of isoproterenol in experimental left ventricular failure. Cardiologia 50: 108, 1967. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Southern California School of Medicine Los Angeles, Calif. 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HADDY, M.D., Ph.D., F.A.C.P. 1 March 1969Volume 70, Issue 3Page: 638-641KeywordsCapillariesCardiac outputCirrhosisIsoproterenolPeritonitisShock Issue Published: 1 March 1969 PDF DownloadLoading ...