gebhart/patrepeval huggingface dataset:
Acute rhinosinusitis in adults: an update on current management (2007)

Acute rhinosinusitis is a common disease with worldwide prevalence. It is a significant burden on the health services. It is most commonly caused by viruses and is self-limiting in nature. The diagnosis of acute rhinosinusitis is clinical and sinus radiography is not indicated routinely. Most cases of acute rhinosinusitis are treated symptomatically. However, symptoms may persist beyond 10 days when secondary bacterial infection prevails. Antibiotics are reserved for moderate or severe cases or when there is development of complications of acute rhinosinusitis. This paper provides an update on the current management of acute rhinosinusitis.
Sur certains groupes d'opérateurs unitaires (1964)

A force d'habitude, le fair que les sdries thSta ddfinissent des fonctions modulaires a presque cess6 de nous dtonner. Mais l'apparition du groupe symplectique comme un deus ex machina dans les cdl6bres travaux de Siegel sur les formes quadratiques n'a rien perdu encore de son caract6re mystdrieux. Le but de ce mdmoire, et de ceux qui lui feront suite, n'est pas, bien entendu, d'dlucider ddfinitivement la question, mais de jeter un peu de lumi6re sur certains aspects de cette thdorie qui dtaient restds dans l'ombre jusqu's prdsent. Une analyse attentive des travaux de Siegel permet en effet de ddceler le rSle capital qu'y joue une certaine reprdsentation unitaire, non pas du groupe symplectique lui-m~me, mais d'une extension centrale de ce groupe, ainsi que des groupes analogues sur les corps p-adiques. I1 se irouve que cette reprdsentation, pour le cas du groupe symplectique rdel (et m~me de sa g~ndralisation naturelle s l'espace de Hilbert), a dtd d~finie et ~tudide rdcemment par D. Shale [7], apr6s que son existence, ou du moins celle de la reprdsentation projective correspondante, eSt dtd reconnue par I. Segal [5] s propos de mdcanique quantique. Celui-ci est revenu sur la question [6], ~ la suite d'un exposd oh j'en avais soulignd l'importance en thdorie des nombres; j'ai empruntd ~ son travail, dont je lui suis reconnaissant de m'avoir communiqu6 le manuscrit, le principe de la ddmonstration du thdor6me d'existence (thdor6me 1 ci-dessous; pour une autre ddmonstration, cf. G. Mackey [3]), ainsi que l'idde de prendre pour point de ddpart la th6orie gdndrale des groupes abdliens localement compacts.
High-frequency ventilation (1988)

Department of Anaesthetics, The Alexandra Hospital, Redditch, UK Current Opinion in Anaesthesiology 1988, 1:481-487
Reviews (2011)

Although the range of research undertaken by universities and colleges covers a very wide spectrum, each of the books in this Kogan Page series is narrowly focused on a particular form of research, that of small-scale 'insider research'. This is defined as research into teaching and learning which is undertaken by tutors with the specific aim of improving their teaching practice. The series is intended to be quick and easy to read, to provide starting points for research into teaching practice, and to give pointers to ways in which outcomes may be recorded and published. It aims to deal with contemporary issues affecting teachers in colleges and universities, and to include a range of research methods with suggestions for how these might be used or adapted in particular circumstances. Each book in the series shares a version of the opening and concluding paragraphs. The opening paragraph introduces a concept of insider research based on the notion of the reflective practitioner of education: this model takes the view that teachers should play an active role in constructing and reconstructing knowledge with the aim of improving teaching. 'Research' is related mainly to the rating system defined by the Higher Education Funding Council for England (HEFCE).DOI:10.1080/0968776960040308
Status of radiation treatment of prostate cancer at Stanford University. (1988)

Over 900 patients have been treated with radiation therapy in the 30-year Stanford prostate study. Overall survival, i.e., scoring death due to all causes, was 45%, 35%, 33%, 20%, and 10% for Stanford stages T0, T1, T2, T3, and T4 (nominal stages A, B1, B2, C) at 15 years; lymph node status was unknown. Disease-specific survival at 15 years was 85%, 64%, 45%, 33%, and 15%, respectively, for the same patients. In 141 patients with restricted nodular disease (lymph node status unknown) equal to or less than one-half of one lobe involved (stage B1), the 15-year overall survival was 50% and identical to the expected survival of an age-matched cohort of males. Potency was preserved in 86% of the patients at 15 months posttreatment, and 50% of the patients maintained erectile potency for 7 years posttherapy. Other sequelae and complications are analyzed. The incidence of second neoplasms did not exceed expectations for an age-matched population.
Disrupted intrinsic functional connectivity in the vegetative state (2008)

It is debatable as to whether the spontaneous blood-oxygen-level dependent fluctuations that are observed in the resting brain in turn reflect consciously directed mental activity or, alternatively, constitute an intrinsic property of functional brain organisation persisting in the absence of consciousness. This report shows for the first time, in three patients, that the persistent vegetative state (PVS) is marked by a dysfunctional default mode network, with decreased connectivity in several brain regions, including the dorsolateral prefrontal cortex and anterior cingulated cortex, especially in the right hemisphere. This finding supports the view that the resting state is involved in self-consciousness, and that the right-hemisphere default state may play a major role in conscious processes. It is speculated that the default state may act as a surrogate marker of PVS with awareness contents and, therefore, could replace a more complex activation paradigm.
Insulin Stimulates and Diabetes Inhibits O-Linked <i>N</i>-Acetylglucosamine Transferase and O-Glycosylation of Sp1 (2004)

Insulin stimulates both the biosynthesis of transcription factor Sp1 and its O-linked N-acetylglucosaminylation (O-GlcNAcylation), which promotes nuclear localization of Sp1 and its ability to transactivate calmodulin (CaM) gene transcription. To investigate this further, we incubated H-411E liver cells with insulin (10,000 microU/ml) and quantified the subcellular distribution of O-GlcNAc transferase (OGT) and O-GlcNAc-modified Sp1. We also examined the phosphorylation of Sp1 using both Western blot and incorporation of 32P into Sp1. The results demonstrate that insulin, but not glucagon, stimulates OGT synthesis and enhances cytosolic staining of OGT (histochemical). Insulin increases O-GlcNAc-Sp1, which peaks at 30 min, followed by decline at 4 h. In contrast, insulin initiates phosphorylation of Sp1 early, followed by a continued increase in phosphorylated Sp1 (PO4-Sp1) at 4 h. A reciprocal relationship between O-GlcNAc-Sp1 and PO4-Sp1 was observed. To explore the pathophysiological relevance, we localized OGT in liver sections from streptozotocin (STZ)-induced diabetic rats. We observed that staining of OGT in STZ-induced diabetic rat liver is clearly diminished, but it was substantially restored after 6 days of insulin treatment. We conclude that insulin stimulates CaM gene transcription via a dynamic interplay between O-glycosylation and phosphorylation of Sp1 that modulates stability, mobility, subcellular compartmentalization, and activity.
E-services at FedEx (2003)

Providing customer services online brought a new dimension to corporate functionalities at Federal Express.
Carbobenzoxy amino acids: structural requirements for cholecystokinin receptor antagonist activity (1985)

We used dispersed acini prepared from guinea pig pancreas to examine 28 carbobenzoxy (CBZ) amino acids for their abilities to function as cholecystokinin receptor antagonists. All amino acid derivatives tested, except for CBZ-alanine, CBZ-glycine, and N alpha-CBZ-lysine, were able to inhibit the stimulation of amylase secretion caused by the C-terminal octapeptide of cholecystokinin. In general, there was a good correlation between the ability of a carbobenzoxy amino acid to inhibit stimulated amylase secretion and the ability of the amino acid derivative to inhibit binding of 125I-cholecystokinin. The inhibition of cholecystokinin-stimulated amylase secretion was competitive, fully reversible, and specific for those secretagogues that interact with the cholecystokinin receptor. The potencies with which the various carbobenzoxy amino acids inhibited the action of cholecystokinin varied 100-fold and CBZ-cystine was the most potent cholecystokinin receptor antagonist. This variation in potency was primarily but not exclusively a function of the hydrophobicity of the amino acid side chain.
Characterization and Classification of Dextrans from Ninety-six Strains of Bacteria<sup>1b</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization and Classification of Dextrans from Ninety-six Strains of Bacteria1bAllene Jeanes, W. C. Haynes, C. A. Wilham, J. C. Rankin, E. H. Melvin, Marjorie J. Austin, J. E. Cluskey, B. E. Fisher, H. M. Tsuchiya, and C. E. RistCite this: J. Am. Chem. Soc. 1954, 76, 20, 5041–5052Publication Date (Print):October 1, 1954Publication History Published online1 May 2002Published inissue 1 October 1954https://doi.org/10.1021/ja01649a011Request reuse permissionsArticle Views678Altmetric-Citations379LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Advances in high-throughput mass spectrometry. (2001)

The evolution of high-throughput drug discovery is readily apparent as the pharmaceutical industry continues to stress the rapid progression of new chemical entities and biological agents through drug discovery and development pipelines. Mass spectrometry and high performance liquid chromatography-mass spectrometry have played an instrumental role in the support and advancement of all facets of high-throughput drug discovery. The introduction of new instrumentation has extended the breadth of mass spectrometric-based capabilities from the characterization of high-throughput organic synthesis products to early adsorption, distribution, metabolism and excretion profiling. Additionally, advances in the capacity and throughput of mass spectrometry systems have concurrently led to the introduction of data management tools to address automated data reduction, archival and mining, as well as analytical data integration to chemical and biological databases.
A case study of management characteristics and new product development. (2009)

This paper explores the changes in management characteristics as individual motivation and degree of complexity, uncertainty and ambiguity vary through stages in developing new products. Management characteristics are defined as autocratic, bureaucratic, entrepreneurial and team-based.
Detecting engagement levels for autism intervention therapy using RGB-D camera (2016)

Our motivation for this work is to develop an autonomous robot system that is able to perform autism intervention therapy. Autism spectrum disorder (ASD) is a common type of neurodevelopmental disorder that affects millions of people in the United States alone. The best way of treating ASD and help people with ASD learn new skills is through applied behavior analysis (ABA, i.e. autism intervention therapy). Because of the fact that people with ASD feel less stressful in a predictable and simple environment compared to interacting with other people and autism intervention therapy provided by professional therapists are generally expensive and inaccessible, it would be beneficial to build robots that can perform intervention therapy with children without a therapist/instructor present. In this research, we focus on the task of detecting engagement/disengagement levels of a child in a therapy session as a first step in designing a therapy robot. In this work, we mainly utilize an RGB-D camera, namely the Microsoft Kinect 2.0, to extract kinematic joint data from the therapy session. We also set up a child study with the Kid’s Creek therapy center to recruit children with ASD and record their interactions with a therapist while working on a touch-screen based game on a tablet. After carefully selecting features derived from skeletons’ movements and poses, we showed that our system can produce an accuracy of 97% when detecting engagements and disengagements using cross-validation assessment.
623 (2012)

Introduction: Pediatric Fundamental Critical Care Support is being taught to a variety of learners, but data on the effectiveness of the course are lacking. Hypothesis: Teaching the Society for Critical Care Medicine’s Pediatric Fundamental Critical Care Support course with the addition of high-fidelity simulation scenarios increases perceptions of self-efficacy in a wide variety of providers, including Pediatric Nurse Practitioners (PNPs), Respiratory Therapists (RRTs), Emergency Medical Technicians (EMTs), Registered Nurses (RNs) and graduating pediatrics PL-1s. Methods: All pediatrics residents completing their first year of training at two institutions and non-physician providers (NPPs) with a variety of credentials from 5 different institutions were taught the course between May, 2010 and May, 2012. The course included two high-fidelity simulations as a capstone experience. Learners completed a survey of 10 5-point Likert scale questions before and after the course regarding their feelings of preparation for managing critical children. Areas assessed included caring for critical pediatric patients, monitoring patients during and chosing medications for intubation, initial and subsequent management of ventilation, leading a code, evaluating and correcting electrolyte abnormalities, arranging transport, providing sedation / algesia, and recognition and initial management of shock states. Results: 71 pediatrics interns and 73 NPPs were taught the PFCCS course. 2 interns and 7 NPPs failed to complete both surveys. Results were compared using a paired Student’s t-test. Interns’ reported feelings of preparation increased by an average of 2.21 points per question, whereas NPPs improved by 1.72 points per question. The improvement in all items were significant at or below p = 0.001. There was no significant difference in change in reported efficacy based on how much of the textbook learners had read prior to the course, or whether or not learners had previous certification in PALS or ACLS – although ACLS approached significance. Conclusions: The PFCCS course reliably improved feelings of preparation for recognition and management of critically-ill children for a wide variety of providers.
Mutual Fund vs. Life Insurance: Behavioral Analysis of Retail Investors (2009)

During the post 1990 period, service sector in most of the Asian economies witnessed growth fueled by significant changes in their financial sector. India is now being ranked as one of the fastest growing economy of the world. During last one decade or so, role of Indian insurance and mutual fund industry as a significant financial service in financial market has really been noteworthy. In fact since 1992, a number of research studies have underlined the importance of these two in the Indian capital market environment as important investment vehicles. But the existing ‘Behavioral Finance’ studies on factors influencing selection of mutual fund and life insurance schemes are very few and very little information is available about investor perceptions, preferences, attitudes and behavior. Yet again, perhaps no efforts are made to analyze and compare the selection behavior of Indian retail investors towards mutual funds and life insurances particularly in post-liberalization period. With this background this paper makes an earnest attempt to study the behavior of the investors in the selection of these two investment vehicles in an Indian perspective by making a comparative study.
Heat exchanger development for waste water heat recovery (2005)

Hot water plays an import role in modem life. The consumption of hot water represents a significant part of the nation's energy consumption. One way of reducing the energy consumption involved, and hence the cost of that energy, is to reclaim heat from the waste warm water that is discharged to the sewer each day. The potential for economic waste water heat recovery depends on both the quantity available and whether the quality fits the requirement of the heating load. To recover heat from waste water in residential and commercial buildings is hard to achieve in quality because of its low temperature range. Nevertheless, efforts to recycle this waste energy could result in significant energy savings. The objective of this research was to develop a multiple panel thermosyphon heat exchanger for a waste water heat recovery system. The advantage of the system proposed in this work is that it not only provides useful energy transfer during simultaneous flow of cold supply and warm drain water but also has the ability to store recovered energy at the bottom of a hot water storage tank for later use. While this concept is not new, the design of the heat exchanger proposed for the present study is significantly different from those used previously. Component experiments were carried out to determine the performance characteristics of a single thermosyphon panel. By changing the inclination angle of the single panel heat exchanger and varying its working condition, it was found that the inclination angle of 10° could be identified as the minimum inclination angle at which good performance was still obtained. The close values of the overall heat transfer coefficients between top surface of the panel insulated and both top and bottom surfaces of the panel uninsulated shows that the overall heat transfer coefficient of the single panel was dominated by the bottom surface of the panel. Even if in a worst case the top surface of the panel might be possibly covered by the deposits from the waste water, it would not affect much on the heat transfer performance of the panel. Measurements of hot water usage and waste water temperature and flow rates were obtained for a potential application of the proposed exchanger (the dishwasher for the kitchen in the University Halls of Residence). A model of a multi-panel thermosyphon heat exchanger was also developed to predict the energy savings that would be expected if such a heat exchanger was used in this situation. The result indicated that an overall electricity of 7500 kWh could be saved annually from the dishwasher system by employing a four-panel thermosyphon heat exchanger.
Hypothesis on the molecular basis of the antifungal activity of <i>N</i>-substituted imidazoles and triazoles (1983)

Conference Article| December 01 1983 Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles HUGO VAN DEN BOSSCHE; HUGO VAN DEN BOSSCHE *Department of Comparative Biochemistry, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium Search for other works by this author on: This Site PubMed Google Scholar GUSTAAF WILLEMSENS; GUSTAAF WILLEMSENS *Department of Comparative Biochemistry, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium Search for other works by this author on: This Site PubMed Google Scholar WILLY COOLS; WILLY COOLS *Department of Comparative Biochemistry, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium Search for other works by this author on: This Site PubMed Google Scholar PATRICK MARICHAL; PATRICK MARICHAL *Department of Comparative Biochemistry, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium Search for other works by this author on: This Site PubMed Google Scholar WILLIAM LAUWERS WILLIAM LAUWERS †Department of Analytical Chemistry, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1983) 11 (6): 665–667. https://doi.org/10.1042/bst0110665 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation HUGO VAN DEN BOSSCHE, GUSTAAF WILLEMSENS, WILLY COOLS, PATRICK MARICHAL, WILLIAM LAUWERS; Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles. Biochem Soc Trans 1 December 1983; 11 (6): 665–667. doi: https://doi.org/10.1042/bst0110665 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1983 Biochemical Society1983 Article PDF first page preview Close Modal You do not currently have access to this content.
Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium. (1993)

The human hormone-sensitive lipase (HSL) gene encodes a 786-aa polypeptide (85.5 kDa). It is composed of nine exons spanning approximately 11 kb, with exons 2-5 clustered in a 1.1-kb region. The putative catalytic site (Ser423) and a possible lipid-binding region in the C-terminal part are encoded by exons 6 and 9, respectively. Exon 8 encodes the phosphorylation site (Ser551) that controls cAMP-mediated activity and a second site (Ser553) that is phosphorylated by 5'-AMP-activated protein kinase. Human HSL showed 83% identity with the rat enzyme and contained a 12-aa deletion immediately upstream of the phosphorylation sites with an unknown effect on the activity control. Besides the catalytic site motif (Gly-Xaa-Ser-Xaa-Gly) found in most lipases, HSL shows no homology with other known lipases or proteins, except for a recently reported unexpected homology between the region surrounding its catalytic site and that of the lipase 2 of Moraxella TA144, an antarctic psychrotrophic bacterium. The gene of lipase 2, which catalyses lipolysis below 4 degrees C, was absent in the genomic DNA of five other Moraxella strains living at 37 degrees C. The lipase 2-like sequence in HSL may reflect an evolutionarily conserved cold adaptability that might be of critical survival value when low-temperature-mobilized endogenous lipids are the primary energy source (e.g., in poikilotherms or hibernators). The finding that HSL at 10 degrees C retained 3- to 5-fold more of its 37 degrees C catalytic activity than lipoprotein lipase or carboxyl ester lipase is consistent with this hypothesis.