gebhart/patrepeval huggingface dataset:
Schiff base polymers derived from 2,5‐diformylfuran (2013)

Abstract Polymerization of 2,5‐diformylfuran with two primary amines was carried out in acetonitrile and ethanol at room temperature. The reaction was characterized using a combination of mass spectroscopy and NMR spectroscopy, which revealed the clean formation of the imine – CH N− functional group. Although some cyclic products were detected from mass spectroscopy, the ring size was limited to products that have the − CH N− group only in anti ‐geometry. The furan Schiff bases exhibit good thermal stability. While mass spectra evidenced oligomers of different lengths, cross‐polarization magic angle spinning 13 C NMR spectra of the insoluble polymer revealed the linear structure as proposed. © 2013 Society of Chemical Industry
Long-term treatment with tamoxifen activates MAP kinase and mTOR pathway and enhances interaction between growth factor receptor and ERα in breast cancer cells (2005)

828 Background: Tamoxifen is an important antiestrogen drug for breast cancer patients. Unfortunately, resistance often happens after long-term treatment. In this study, breast cancer cell line MCF-7B cells were used to detect the signal pathway and receptors changes after long-term treated with tamoxifen(TAM). Methods: Breast cancer cells MCF-7B were treated with 10−7 mol/L TAM. Western blots were used to detect intensity of Akt, MAPK (the mitogen-activated protein kinase), mTOR (mammalian target of rapamycin), p70S6K, 4EBP-1 and ERα. Immunoprecipitation was used to detect the changes of EGFR, IGF-1R and ERα.Results: After about one month treatment, TAM could remarkedly induce p42/44 MAPK activation and phosphorylation residues Thr389 of p70S6K. But Akt and 4EBP-1 do not change. U0126(10uM), an inhibitor of the MAPK and rapamycin(2nM), an inhibitor of the mammalian target of mTOR, could result in decreasing the p70S6 kinase phosphorylation induced by TAM. MCF-7B cells with increased phosphorylation of p70S6K were insensitive to TAM, but two inhibitors or combining with TAM could significantly inhibit the MCF-7B growth. After long-term tamoxifen treatment, there was no change in ERα expression detecting by Western blots. After performing IGF-1R and EGFR immunoprecipitation, there was no significant difference between TAM treated cells and control cells in immunoblotting IGF-1R and EGFR. But ERα binding with EGFR and IGF-1R is significantly higher in TAM treated cells than that in control.Conclusions: Long-term TAM treated MCF-7B cells can increase phosphorylation of MAPK and p70S6K. At early time breast cancer cells can use this way to survive. And MCF-7B cells could resistant to long-term tamoxifen treatment through increasing expression level of ERα binding to growth factor receptors such as EGFR and IGF-1R. No significant financial relationships to disclose.
Operation of NIST Josephson array voltage standards (1990)

This paper begins with a brief discussion of the physical principles and history of Josephson effect voltage standards. The main body of the paper deals with the practical details of the array design, cryoprobe construction, bias source requirements, and adjustment of the system for optimum performance, calibration algorithms, and an assessment of error sources for the NIST -developed Josephson array standard.
Opakovaná lokální trombolýza u poranění a trombózy axilární a podklíčkové žíly (2009)

Hluboka žilni tromboza (DVT) je onemocněni s tvorbou krevnich sraženin (trombů) v hlubokých žilach. Na hornich koncetinach (HKK) je sice DVT vzacna, ale i tak je onemocněni zavažne vzhledem k možným komplikacim. Leceni DVT na HKK se provadi podkožnimi injekcemi nizkomolekularnimi hepariny a nasledným převodem na p.o. antikoagulaci ci trombolýzou, ktera se podava v indikovaných připadech (tromboza podklickove žily) a spociva v nitrožilni aplikaci trombolytika. Je prezentovan připad profesionalni sportovkyně, u ktere jsme lecili žilni trombozu podklickove a pažni žily pomoci lokalni trombolýzy. Tromboza vznikla nahle po basketbalovem zapasu, kdy doslo po uderu balonem do oblasti podpaži k otoku prave horni koncetiny. Punkce žily i veskere repozice katetru byly provedeny pod duplexni ultrazvukovou kontrolou (DUS). Byla punktovana proximalni v. brachialis a ctyřfrencovými (4F) katetry bylo proniknuto do v. subclavia. K trombolýze byla použita alteplaza (rt-PA) v koncentraci 0,2-0,6 mg/hod. Po uplnem rozpustěni trombozy v podklicku a podpaži bylo nasledujici den patrne poraněni intimy podpažni žily a ihned po ukonceni infuze s trombolytikem doslo k opětne tromboze ve stejne lokalizaci. Proto bylo přistoupeno k opětne aplikaci trombolytika do stejneho mista a do medikace byla přidana kyselina acetylsalicylova. Při teto kombinovane terapii doslo k opětne rekanalizaci jak na paži, tak i v podpaži a v podklicku. Trombolýza byla ukoncena 3. den od pocatku lecby. Metodu lze použit při řeseni hluboke žilni trombozy na hornich koncetinach i bez RTG kontroly. Ultrazvukem kontrolovana lokalni trombolýza hluboke žilni trombozy je u indikovaných pacientů bezpecnou metodou i u připadů, kdy doslo k poraněni žily.
Caveolae: where incoming and outgoing messengers meet. (1993)

Plasmalemmal caveolae were first identified as an endocytic compartment in endothelial cells, where they appear to move molecules across the cell by transcytosis. More recently, they have been found to be sites where small molecules are concentrated and internalized by a process called potocytosis. A growing body of biochemical and morphological evidence indicates that a variety of molecules known to function directly or indirectly in signal transduction are enriched in caveolae. This raises the possibility that a third function for caveolae is to process hormonal and mechanical signals for the cell. Insights gained from studying potocytosis suggest several different ways that this membrane specialization might function to integrate incoming and outgoing cellular messages.
Ultrafast Ultrasound Imaging Using Combined Transmissions With Cross-Coherence-Based Reconstruction (2017)

Plane-wave-based ultrafast imaging has become the prevalent technique for non-conventional ultrasound imaging. The image quality, especially in terms of the suppression of artifacts, is generally compromised by reducing the number of transmissions for a higher frame rate. We hereby propose a new ultrafast imaging framework that reduces not only the side lobe artifacts but also the axial lobe artifacts using combined transmissions with a new coherence-based factor. The results from simulations, in vitro wire phantoms, the ex vivo porcine artery, and the in vivo porcine heart show that our proposed methodology greatly reduced the axial lobe artifact by 25±5 dB compared with coherent plane-wave compounding (CPWC), which was considered as the ultrafast imaging standard, and suppressed side lobe artifacts by 15 ± 5 dB compared with CPWC and coherent spherical-wave compounding. The reduction of artifacts in our proposed ultrafast imaging framework led to a better boundary delineation of soft tissues than CPWC.
Lack of Efficacy of Acetaminophen in Treating Symptomatic Knee Osteoarthritis (2003)

Diclofenac is effective in the symptomatic treatment of OA of the knee, but acetaminophen is not. A review of the literature reveals that there is scanty published evidence for a therapeutic effect of acetaminophen relative to placebo in patients with OA of the knee, because most published studies use active comparators (ie, nonsteroidal anti-inflammatory drugs) only. The advocacy of acetaminophen use in subjects with OA of the knee should be reconsidered pending further placebo-controlled studies.
An application of paddlewheel propulsion to a high speed craft (2011)

The paddle wheel has existed as a marine propulsor for in excess of two hundred years yet has been developed little over the last one hundred years. It could be concluded that the paddle has stagnated as a means of efficient propulsion for today‟s marine vessels. As technology develops in other areas, is it possible that paddle propulsion could find applications not yet considered? Has the paddle reached its maximum potential? This paper challenges the assumption that paddle forms of propulsion are ineffective at high rotational speeds through two means: a report on a set of trials of a relatively high powered and high rotational speed paddle wheel fastened to a purpose built 8m long planing skiff which achieved speeds in excess of 32 knots; and results from previous experimental work on paddles, carried out in the Denny experiment tank at Dumbarton, Scotland, were non-dimensionalised, replotted and applied to predict and interpret the performance of the paddle operated on the planing skiff. The paddle achieves propulsion through a relatively large swept area, thus achieving the potential for relatively high efficiency of propulsion. The present design operated with low immersion, up to about 75mm, but at lower immersions down to 5mm at higher speeds, in the wake behind an immersed transom stern. The paper reports on performance of this paddle and interprets the results in the light of the existing historical experimental results.
Effect of pH and the presence of NaCl on some hydration properties of collagenous material from trout (<i>Salmo irideus</i> Gibb) muscle and skin (1991)

Abstract Various hydration properties (solubility, water binding capacity and viscosity) of collagenous material from muscle connective tissue and skin are analysed in terms of pH and NaCl concentration in the medium. In general terms it is found that functionality is at its greatest where pH is between 2 and 4, and that the addition of NaCl reduces functionality, except in the case of viscosity. Both collagenous materials react similarly to changes deriving from pH and the addition of NaCl. The data are relevant to the possible utilisation of waste products from the fish industry as functional ingredients in other foodstuffs.
Developments in Structural Genomics: Protein Purification and Function Interpretation (2004)

As more and more genomes have been sequenced, the hotspot of biological science is moving from the study on nucleic acids to that on proteins. One of the most representative affairs in this era is the launching of projects focusing on the high throughput determination of the protein three dimensional structures in a genome scale, named structural genomics projects. The common objective of the pilot projects is construction of a platform to clone hundreds to thousands of targets, and purify, at the first stage, the highly expressed and soluble proteins, then solve dozens to hundred of structures by means of X-ray crystallography or NMR. The first bottleneck in this pipeline is obtaining manipulable quantity (milligram level according to the necessity of the current crystallographic or NMR technology) of soluble proteins, which are properly folded. For this purpose, a series of methodologies have been established. His-tag makes it possible to purify the desired protein from the crude extract of the host cells or the mix of in vitro expression system in a single step of affinity purification. Beyond His-tag and other short affinity tags, a series of fusion tags have been developed for the purpose of solubility enhancement. Many expression hosts based on bacterium Escherichia coli or yeast Pichia pastoris have been constructed to express heterologous proteins. The influences of temperature during induction and co-expression with chaperones are systematically investigated. The effects of the N-terminal tags, either small or big ones, are examined and compared with those carrying a tag at the C-terminus. Some techniques of in vitro evolution are transferred and applied to increase the expression level and solubility of the targets. These efforts are helpful, at least at one hand, for speeding up the production of folded and concentrated proteins, the sample feeding the crystallographers and NMR spectroscopists. Furthermore three newly determined structures by the pilot structural genomics projects were shown to demonstrate how to decipher biological function from the 3-D structure of a novel protein and how to interpret the structure-function relationship and its application on drug design. In present paper, we review the popular techniques applied in the current structural genomics projects, their effects and possible improvements in the future, especially those for protein preparation and function interpretation. Keywords: structural genomics, overexpression, high throughput, purification, affinity tag, solubility enhancement tag, directed evolution
Posthemorrhagic Dilation of the Neonatal Fourth Ventricle (1992)

A retrospective review of 285 very‐low‐birth‐weight infants with periventricular‐intraventricular hemorrhage revealed that 20 infants developed posthemorrhagic dilation of the fourth ventricle. Evaluation of the survivors for 16 months (mean follow‐up period) showed a statistically significant increase in severe disability and in impaired cognitive development, compared with an equal number of control subjects matched for birth weight and grade of hemorrhage. These findings indicate that very‐low‐birth‐weight infants who develop dilation of the fourth ventricle following periventricular‐intraventricular hemorrhage have a greater likelihood of a poor outcome than those who do not have this complication. The predictive function of this sign appears to be independent of the grade of hemorrhage.
Analysis of Password and Salt Combination Scheme To Improve Hash Algorithm Security (2019)

In system security, hashes play important role in ensuring data. It remains the secure and the management of access rights by those entitled to. The increasing power of hash algorithms, various methods, are carried out one of them using salting techniques. Salt is usually attached as a prefix or postfix to the plaintext before hashing. But applying salt as a prefix or postfix is not enough. There are so many ways to find the plaintext from the resulting cipher text. This research discusses the combination scheme other than the prefix and postfix between password and salt increasing the security of hash algorithms. There is no truly secure system and no algorithm that has no loopholes. But this technique is to strengthen the security of the algorithm. So that, it gives more time if an attacker wants to break into the system. To measure the strength generated from each combination scheme, a tool called Hashcat is used. That is the way known as the best composition in applying salt to passwords.
Synthesis, Resolution, and Absolute Configuration of Optically Pure 5,5''-Dihydroxy-4',4''',7,7''-tetramethoxy-8,8''-biflavone and Its Derivatives (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, Resolution, and Absolute Configuration of Optically Pure 5,5''-Dihydroxy-4',4''',7,7''-tetramethoxy-8,8''-biflavone and Its DerivativesFang-Jie Zhang, Guo-Qiang Lin, and Qi-Chen HuangCite this: J. Org. Chem. 1995, 60, 20, 6427–6430Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/jo00125a031https://doi.org/10.1021/jo00125a031research-articleACS PublicationsRequest reuse permissionsArticle Views499Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
An FPGA-based coprocessor for image processing (1994)

Reconfigurable field programmable gate arrays (FPGAs) are a new technology suitable for building fast and flexible processing systems. This paper contains an overview of the first ever FPGA-based coprocessor for an image processing system. The system provides the performance of custom hardware with the added flexibility of an equivalent software-based system. Benchmark results are given for the time taken to perform two typical image processing functions.
Plant mucilages. XXX. Isolation and characterization of a mucilage, "dioscorea-mucilage B," from the rhizophors of Dioscorea batatas. (1981)

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SEPARATION AND SPECIATION OF INORGANIC AND METHYLARSENIC COMPOUNDS IN MARINE SAMPLES (1995)

A combination of an extraction and two-step ion-exchange process has been developed for the separation and speciation of As(III), As(V) and their methylated forms mono-(MMA) and dimethylarsenic acid (DMA) at trace levels in marine samples. As(III) was first separated from all investigated As-compounds by extraction with ammonium pyrrolidinedithiocarbamate (APDC) into isobutylmethylketone (IBMK) at pH = 2 and determined after backstripping with HCl (1:1) by hydride-generation AAS. The remaining As species were passed through the cation exchange resin Dowex 50W-X8, where DMA was quantitatively retained As(V) and MMA, present in the effluent, were subsequently fixed in the anion exchanger AG1-X8. Experimental conditions, including pH of the sample solutions and competing ions were studied in order to achieve quantitative retention of these As compounds. By sequential elution, a good separation of the individual As species was obtained. The As concentration in each fraction as well as total arsenic were determined by the hydride generation AAS technique. The developed process has been applied to the analysis of simulated synthetic As mixtures obtained from BCR and of real marine samples.
Strategic planning: a balanced view of a balanced portfolio. (1986)

The application of portfolio analysis to strategic planning in health care organizations is presented. The practical use of this approach is demonstrated through a case example. Advantages and disadvantages of the approach are delineated.
Hierarchical object models for efficient anti-collision algorithms (2003)

The author presents an offline programming system specially designed for complex robotic applications (e.g., intervention of redundant manipulators in a nuclear plant). It uses hierarchical CAD models of solids and manipulators. These models are derived from constructive solid geometry trees and combine simple volume primitives with union or difference set operations. They offer different levels of description of the objects and enable an efficient computation of local minima of the distance between points of the objects. By setting constraints on the variation of the distance at these points, it is possible to produce collision-free trajectories achieving complex tasks with Cartesian and/or joint parameter goals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nucleic Acid Relatedness Studies on the Genus Carnobacterium and Related Taxa (1989)

None of the species Carnobacterium piscicola, C. divergens, C. mobile or C. gallinarum showed significant DNA-DNA homology between themselves and other lactic acid bacteria [corrected]. Nevertheless, the Carnobacterium species were found to belong to the same ribosomal RNA homology cluster. The species in this cluster were distant from the other bacteria tested.
Analysis and guidelines for high-speed VLSI system interconnections (2003)

A description is given of the modeling and analysis procedures used to generate system-level wiring rules and net delay equations for IBM's 1.0- mu n CMOS standard-cell design system VLSI products. Business rationale, circuit and package models, and analysis methods are reviewed, as is a sample of the result in a midrange processor environment. High-performance single and multichip packages are used in the analysis, as are high-reliability under- and over-voltage specifications. These choices target the analysis for high-cost, high-performance applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Production of lipopolysaccharide‐induced tumour necrosis factor during influenza virus infection in mice coincides with viral replication and respiratory oxidative burst (1995)

Increased morbidity and mortality occur regularly during influenza epidemics. The exact mechanisms involved are not well defined but bacterial superinfection of influenza virus infected patients is considered to play an important role. In the present study, the effect of influenza virus infection on in vivo production of turnout necrosis factor (TNF) in response to bacterial stimuli was investigated. Release of TNF in mice infected by an aerosol of influenza virus was significant after administration of bacterial lipopolysaccharide (LPS) at 72 h, whereas administration of homologous influenza virus produced only modest amounts of TNF at 96 h. Significant production of TNF was observed 48 h after intravenous administration of infectious influenza in response to LPS but not with the homologous virus. TNF induced after influenza virus infection could be blocked by a specific murine anti-TNF monoclonal antibody. Higher TNF production following aerosol influenza infection correlated with peak titres of influenza virus in the lungs of infected mice and with enhanced generation of luminoldependent chemiluminscence.
Anthocyanin Concentration of “Assaria” Pomegranate Fruits During Different Cold Storage Conditions (2004)

The concentration of anthocyanins in fruits of "Assaria" pomegranate, a sweet Portuguese cultivar typically grown in Algarve (south Portugal), was monitored during storage under different conditions. The fruits were exposed to cold storage ( $5^{\circ}$ C) after the following treatments: spraying with wax; spraying with $1.5$ % CaCl(2); spraying with wax and $1.5$ % CaCl(2); covering boxes with 25 $\mu$ c thickness low-density polyethylene film. Untreated fruits were used as a control. The anthocyanin levels were quantified by either comparison with an external standard of cyanidin 3-rutinoside (based on the peak area) or individual calculation from the peak areas based on standard curves of each anthocyanin type. The storage time as well as the fruit treatment prior to storage influenced total anthocyanin content. The highest levels were observed at the end of the first month of storage, except for the fruits treated with CaCl(2), where the maximal values were achieved at the end of the second month. The anthocyanin quantification method influenced the final result. When total anthocyanin was calculated as a sum of individual pigments quantified based on standard curves of each anthocyanin type, lower values were obtained.