gebhart/patrepeval huggingface dataset:
Penciclovir Cream for the Treatment of Herpes Simplex Labialis (1997)

<h3>Objective.</h3> —To compare the safety and efficacy of topical 1% penciclovir cream with vehicle control cream (placebo) for the treatment of a recurrent episode of herpes simplex labialis (cold sores) in immunocompetent patients. <h3>Design.</h3> —Randomized, double-blind, placebo-controlled, patient-initiated, 2-armed, parallel clinical trial. Patients were prospectively dispensed study medication, and treatment was self-initiated by the patient within 1 hour of the first sign or symptom of a recurrence. <h3>Setting.</h3> —A total of 31 ambulatory clinics in the United States in a variety of settings, including private practices, public health facilities, and universities. <h3>Patients.</h3> —Otherwise healthy individuals with a history of frequent episodes of herpes simplex labialis. A total of 2209 patients were enrolled and given study medication, and 1573 initiated treatment for a recurrence. <h3>Interventions.</h3> —Topical 1% penciclovir cream or vehicle control cream. Subjects applied treatment every 2 hours while awake for 4 consecutive days. <h3>Main Outcome Measures.</h3> —Lesion healing was the primary efficacy variable. Secondary end points included time to loss of lesion pain and time to cessation of viral shedding. <h3>Results.</h3> —Healing of classical lesions (vesicles, ulcers, and/or crusts) was 0.7 day faster for penciclovir-treated patients compared with those who received vehicle control cream (median, 4.8 days vs 5.5 days; hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.18-1.49;<i>P</i><.001). Pain (median, 3.5 days vs 4.1 days; HR, 1.22; 95% CI, 1.09-1.36;<i>P</i><.001) and lesion virus shedding (median, 3 days vs 3 days; HR, 1.35; 95% CI, 1.10-1.64;<i>P</i>=.003) also resolved more quickly for penciclovir-treated patients compared with patients who applied the vehicle control. The efficacy of penciclovir cream was apparent when therapy was initiated early (prodrome or erythema lesion stage) and when initiated late (papule or vesicle stage). The incidence of adverse events was comparable between penciclovir and placebo groups. <h3>Conclusions.</h3> —Penciclovir cream is the first treatment to clearly demonstrate an impact on the course of recurrent herpes labialis in immunocompetent patients. Efficacy was seen in all clinical and laboratory measures of the disease (lesion healing, pain resolution, and cessation of viral shedding). Faster healing and pain resolution occurred both among patients who first applied penciclovir cream in the prodrome and erythema stages and among those who started treatment in the papule and vesicle lesion stages.
Review: Hepatocellular carcinoma: the place of new medical therapies (2010)

Medical therapies have entered center stage in the treatment of hepatocellular carcinoma (HCC) little more than a year after the positive results of a large phase III trial of sorafenib showed a clear survival benefit with sorafenib, a targeted agent, in this setting. Even though this marks a breakthrough in the treatment of HCC, the narrow patient profile necessary for the study to be successful has generated a number of questions regarding the efficacy of this approach in other clinical settings. New studies aiming to define the role of sorafenib from in the adjuvant setting, through patients with more advanced liver disease, all the way to combination treatments of HCC have been initiated. The success of one targeted drug has stimulated enormously the efforts of competitors to develop additional and better drugs, either in a first-line or a second-line setting. These are exciting times for the treatment of HCC, both for physicians and patients. In the years to come we will see an extension of treatment options in different clinical situations in patients with HCC, and survival will be improved in many stages of the disease, except for the most advanced. The rapid increase in knowledge about the molecular mechanisms underlying the development and progression of HCC will lead to a more tailored approach to treatment depending on the molecular characteristics of the tumor and the disease stage.
The analysis of proportions in agricultural experiments by a generalized linear mixed model (1993)

This paper is concerned with the statistical analysis of proportions involving extra‐binomial variation. Extra‐binomial variation is inherent to experimental situations where experimental units are subject to some source of variation, e.g. biological or environmental variation. A generalized linear model for proportions does not account for random variation between experimental units. In this paper an extended version of the generalized linear model is discussed with special reference to experiments in agricultural research. In this model it is assumed that both treatment effects and random contributions of plots are part of the linear predictor. The methods are applied to results from two agricultural experiments.
Background emission from the peroxyoxalate chemiluminescence reaction in the absence of fluorophores (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBackground emission from the peroxyoxalate chemiluminescence reaction in the absence of fluorophoresB. Mann and Mary Lynn. GrayeskiCite this: Anal. Chem. 1990, 62, 14, 1532–1536Publication Date (Print):July 15, 1990Publication History Published online1 May 2002Published inissue 15 July 1990https://pubs.acs.org/doi/10.1021/ac00213a038https://doi.org/10.1021/ac00213a038research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Use of frequency diversity and Nakagami statistics in ultrasonic tissue characterization (2001)

The Nakagami distribution was recently proposed as a generalized model for the envelope of the backscattered ultrasonic echo from tissue. The parameters of the Nakagami model were also shown to be useful in tissue characterization. This paper explores the possibility of enhancing the ability of these parameters for tissue characterization through the techniques of diversity and compounding. Frequency diversity has been used to create multiple versions of the envelope, which are then combined. This compounded envelope has been modeled, and its parameters have been analyzed. The ability of these new parameters to enhance tissue characterization is studied using computer simulation and experiments on tissue-mimicking phantoms. Results indicate that the use of frequency diversity and compounding may indeed improve the ability of the parameters of the Nakagami model to separate different number densities of scatterers. Therefore, it is suggested that such an approach may lead to better techniques in ultrasonic tissue characterization.
The potential of rotary-wing UAV-based magnetic surveys for mineral exploration: A case study from central Sweden (2017)

Abstract Unmanned aerial vehicle (UAV)-based geophysical surveys are attractive for land mineral exploration and are gradually opening extraordinary opportunities in providing high-resolution definition of geologic structures and for direct targeting of mineral deposits. There are, however, challenges such as electromagnetic noise from the UAV, limited load capacity, and short flight times. If these are overcome, there will be a new era in using UAV-based geophysical systems for mineral exploration and for a number of mining-related purposes. In this study, we have tested the potential of rotary-wing UAV systems, given their flight flexibility and robustness for direct targeting of iron-oxide deposits in central Sweden. A walking-mode high-precision Overhauser magnetometer was reassembled so that it could be lifted by the rotary-wing system. Successful backyard tests were performed, but during the real experiment several issues related to high UAV noise level and extreme magnetic field from the mineralization delayed data acquisition. At the end, within nearly three hours and 10 sorties, approximately 20 km-line total-field magnetic data were collected covering an area of about 2 km2. Flight lines were designed perpendicular to the strike of the mineralization to maximize data sampling. Two distinct mineralized zones, magnetite- and hematite-rich and only 50–100 m apart, are notable in the magnetic data due to the fine sampling spacing provided by the UAV survey. Historical low-altitude (30 m above the ground) fixed-wing aeromagnetic data are available from the study area and are compared with the UAV data. Both data sets are consistent in delineating the mineralization, therefore demonstrating the potential of UAV-based surveys for mineral exploration in geologically and logistically challenging areas.
Reducing Shock Interactions in Transonic Turbine via Three-Dimensional Aerodynamic Shaping (2014)

In a high-pressure turbine that is used in combination with a contrarotating low-pressure turbine, the geometry of the low-pressure turbine guide vane gives rise to a shock reflection that has a significant impact on the upstream blade. In consequence, both the performance of the high-pressure turbine and its resistance to high-cycle fatigue failure (i.e., its durability) can be affected. Here, a series of design studies is undertaken in an attempt to mitigate the unsteadiness that arises due to shock interactions in such a turbine. A new method for estimating the forcing function experienced by the high-pressure turbine blade is proposed and evaluated. This method, identified as approximation by surface normal projections, requires only the airfoil geometries and locations as input and demonstrates a significant advantage over an approach to three-dimensional aerodesign consisting exclusively of time-resolved, multirow simulations. The implementation of the approximation by surface normal projections method, in conjunction with a genetic algorithm, is shown to have resulted in superior airfoil geometries with respect to preventing high-cycle fatigue failure and with a reduction of computation time for the analysis of a single airfoil by four orders of magnitude.
Industrial High Pressure Processing of Foods: Review of Evolution and Emerging Trends (2012)

High Pressure Processing (HPP), in the range of 200 MPa to 600 MPa/29,000 psi to 87,000 psi, is the most advanced emerging non-thermal processing technology for food. The constant improvements of high pressure equipment concerning productivity and production costs have facilitated the increase of industrial uses of the technology. This paper reviews some of these advances in high pressure food processing including development of new functional beverages the new value proposals being offered by copackers substitution of traditional thermal techniques for novel product manufacturing and refrigerated services suppliers. Substitution of thermal treatments for meat processing and tenderisation of low value meat cuts.
Multiple origins of the human glycophorin Sta gene. Identification of hot spots for independent unequal homologous recombinations. (1991)

Human glycophorin Sta (HGpSta), one of the structural variants of erythrocyte membrane sialoglycoproteins, is encoded by a delta-alpha hybrid gene that arose from a single unequal crossover between the parent HGpB(delta) and HGpA(alpha) genes. We report here the identification of two new HGpSta genes (type A and type B) in four unrelated Sta heterozygotes from two ethnic groups. These Sta genes represent distinct genetic isoforms that differ from the previously reported Sta gene (type C) in the location of crossing-over sites. Comparison of nucleotide sequences among HGpB(delta), HGpA(alpha), and HGpSta type A genes revealed that the delta-alpha unequal crossover for the Sta type A gene occurred 110-246 base pairs downstream from pseudoexon III. In the crossing-over site of this Sta gene, an AT-rich sequence lying 3' to a nonameric palindrome was found to be highly similar to the lambda phage attachment site, att B, in inverted orientation. In the Sta type B gene, the delta-alpha crossing-over point was localized to an AG-rich sequence that is 302-490 base pairs downstream from pseudoexon III. Multiple lambda chi-like elements were identified at the crossover boundaries and within the breakpoint of this Sta gene. These results suggest strongly that recurrent and independent unequal recombination events have occurred in the formation of multiple Sta genes and that particular genomic sequences are important in defining the recombination sites for these homology-driven processes.
The Steric Inhibition of Resonance in Aromatic Nitro Compounds<sup>1</sup> (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Steric Inhibition of Resonance in Aromatic Nitro Compounds1G. W. Wheland and A. A. DanishCite this: J. Am. Chem. Soc. 1940, 62, 5, 1125–1127Publication Date (Print):May 1, 1940Publication History Published online1 May 2002Published inissue 1 May 1940https://pubs.acs.org/doi/10.1021/ja01862a035https://doi.org/10.1021/ja01862a035research-articleACS PublicationsRequest reuse permissionsArticle Views134Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the use of tapered linearly chirped gratings as dispersion-induced distortion equalizers in SCM systems (1997)

We report on the use of tapered linearly chirped fiber gratings to equalize dispersion-induced distortion in long distance/broad-band subcarrier multiplexed (SCM) systems. Different apodization functions for the coupling factor of the fiber grating have been considered and their equalizing capability of fiber-induced distortion in a subcarrier system have been compared. The results of the theoretical analysis show that both harmonic and intermodulation distortions are significantly reduced when the equalizer parameters have been properly designed. Higher reduction of the nonlinear distortion is obtained when the length of the filter increases, even though a saturation effect on this reduction figure appears when the equalizer length is about four or five times its minimum value to achieve equalization, which is derived theoretically based on the SCM optical system parameters. The performance of a Tanh-type tapered linearly chirped grating equalizer on a realistic broadband SCM system is also considered. The results reveal that the dispersion-induced distortion can be neglected when the equalizer is employed.
Electrical isolation of pin photodiode devices by oxygen ion bombardment (1996)

Using the Hall-effect measurements, the resistance changes in Si-doped (5 × 10 17 cm −3 ), 1 μm thick epilayers of InGaAs and in InP/InGaAs pin structures were studied as functions of multiple-energy oxygen ion dose, implant temperature (−196 and 18 °C), and rapid thermal-anneal (RTA) temperatures. In the case of InGaAs epilayers, the peak resistivity is attained following post-implant RTA at 400–500 °C, with samples implanted at −196 °C exhibiting at least a factor of 10 larger resistivity than those implanted at 18 °C (10 6 vs. 10 5 Ω/⁪). The thermal stability of the induced resistivity is also dependent on the implant temperature and the ion dose. The results suggest that for InGaAs layers, sheet resistances in excess of 10 6 Ω/⁪, stable to temperatures in excess of the anticipated pin device processing temperatures, can be produced by 16 O ion implantation. The use of O ion bombardment to produce planar, implant-isolated pin photodiodes with excellent dark-current and frequency response characteristics has been demonstrated.
Cyclopentadienyl-ruthenium and -osmium chemistry. IV. Convenient high-yield synthesis of some cyclopentadienyl ruthenium or osmium tertiary phosphine halide complexes (1977)

High-yield one-pot syntheses of RuCl(PR3)2(η-C5H5) (R = Ph or p-MeC6H4) and OsBr(PPh3)2- (η-C5H5) from ruthenium or osmium halides, the tertiary phosphine and cyclopentadiene are described.
Vaccinia Virus Inhibits NF-κB-Dependent Gene Expression Downstream of p65 Translocation (2013)

The transcription factor nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) plays a critical role in host defense against viral infection by inducing the production of proinflammatory mediators and type I interferon. Consequently, viruses have evolved many mechanisms to block its activation. The poxvirus vaccinia virus (VACV) encodes numerous inhibitors of NF-κB activation that target multiple points in the signaling pathway. A derivative of VACV strain Copenhagen, called vv811, lacking 55 open reading frames in the left and right terminal regions of the genome was reported to still inhibit NF-κB activation downstream of tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β), suggesting the presence of one or more additional inhibitors. In this study, we constructed a recombinant vv811 lacking the recently described NF-κB inhibitor A49 (vv811ΔA49), yielding a virus that lacked all currently described inhibitors downstream of TNF-α and IL-1β. Unlike vv811, vv811ΔA49 no longer inhibited degradation of the phosphorylated inhibitor of κBα and p65 translocated into the nucleus. However, despite this translocation, vv811ΔA49 still inhibited TNF-α- and IL-1β-induced NF-κB-dependent reporter gene expression and the transcription and production of cytokines induced by these agonists. This inhibition did not require late viral gene expression. These findings indicate the presence of another inhibitor of NF-κB that is expressed early during infection and acts by a novel mechanism downstream of p65 translocation into the nucleus.
Dynamic Obstacle Avoidance for UAVs Using a Fast Trajectory Planning Approach (2019)

Real-time path planning is crucial to the dexterity of UAVs when traversing through environments with unknown obstacles. In this paper, we proposed such a real-time planning algorithm that can be used in cluttered environments. The real-time computation is achieved by using dimensionality reduction as well as the rolling optimization. We test the algorithm both in the Gazebo simulation and in two real experiments. The results show that our algorithm can maintain a relatively high speed flight while avoiding obstacles successfully.
A contour approach for image-based control on objects with complex shape (2002)

We describe a method to achieve robotic positioning tasks by image-based visual servoing when the object being observed has a complex and unknown shape. We first focus on the computation of an analytical expression of the interaction matrix according to a polar description of the image contour of the object. Experimental results are presented to validate the proposed algorithm. In particular, the robustness of the control law is tested with respect to a coarse calibrated system, to an approximation of the depth of the object, and to partial occlusion.
Distribution of Progesterone and Its Effect on Human Blood During Storage (1976)

Human blood, drawn into ACD, was stored under blood bank conditions with and without addition of tritium-labeled progesterone. At selected storage intervals, several biochemical and biophysical parameters were assayed and the distribution of the hormone between plasma and erythrocytes was determined. The retention of the radioactive material by erythrocytes was studied by repeated washes and isotonic saline. The results indicate that erythrocytes stored with addition of progesterone have higher ATP levels, less spontaneous lysis, higher osmotic resistance, and higher uptake of methylene blue throughout the time of storage than do cells stored without added progesterone. This hormone appears to be in steady-state equilibrium between plasma and red blood cells during 42 days of storage and the amount in the plasma is almost twice that present in the cells. After repeated saline washes, about 10 er cent of the progesterone remains attached to the erythrocytes. Specific association of progesterone with red blood cell populations of different density shows that high specific activity is obtained in cell populations of low density (young cells) throughout the storage time investigated.
Supporting Collaboration through Multimedia Digital Document Archives (2000)

.....................................................................................2 1 Introduction ................................................................................2 2 Background to Studies---IMS GNOSIS Test Case ...................................4 3 Digital Movies as Tutorial Demonstrations ...........................................6 3.1 Topic of the Movie............................................................................................. 6 3.2 Production of the Movie ...................................................................................... 7 4 Capturing a Workshop in a Multimedia Proceedings ................................9 5 Archiving a Research Program on CD-ROM ....................................... 11 5.1 Read-Only and Speed Constraints ....................................................................... 11 5.2 Multi-Platform Formatting................................................................................. 12 5.3 ...