gebhart/patrepeval huggingface dataset:
Association of tumorigenic and nontumorigenic (immunogenic) variants in a mouse t‐cell lymphoma with two distinct <i>p53</i> mutations (1993)

An in vitro model system for xenogenization has been developed in which an immunogenic, nonmalignant phenotype was selected from a highly malignant T-cell line (S49). We showed by single-strand conformation polymorphism and DNA sequence analysis that specific point mutations in the p53 tumor suppressor gene correlated with a change from a tumorigenic to a nontumorigenic (immunogenic) phenotype. Specifically, we found that the highly malignant S49 cell line T-60 contains an Arg-->Gln substitution at residue 246 in exon 7 of p53. In contrast, nontumorigenic (immunogenic) variants (T-25-Adh and Rev-1) exhibited a Gly-->Ser substitution at residue 242 of p53. In two subsequent tumorigenic revertants derived from Rev-1, we again found the Arg-->Gln substitution at residue 246 that was found initially in the T-60 cells. Thus, mutation at residue 246 of p53 was associated with a highly malignant phenotype, whereas a novel mutation at residue 242 of p53 appeared to be associated with a nonmalignant phenotype and may have actually protected the host through immunization. We conclude that mutation of residue 242 may represent a new class of permissive (nonmalignant) mutations in the mouse that are analogous to the Li-Fraumeni mutation in humans.
Design of very high <i>Q</i> sapphire resonators (1996)

The design of shielded sapphire dielectric resonators, based on rigorous solutions to Maxwell's equations is described. Rayleigh-Ritz and finite element methods were employed for computations of the resonant frequencies, electric energy filling factors, geometrical factors and Q-factors relating to dielectric and conductor losses for such resonant structures. Results of computations have been compared with experiments.
Characterization of primary and secondary forms of Xenorhabdus luminescens strain Hm (1988)

Cultures of the primary form of Xenorhabdus luminescens strain Hm gave rise to secondary forms after prolonged static incubation in two broth media. The secondary forms were deficient in pigmentation and extracellular antibiotic, protease and lipase activities, and were about 100-fold less luminous than the primary form in vivo. Secondary forms isolated on two separate occasions from two different media were identical in their deficiencies. Cultures of the secondary form in defined broth media produced no detectable secondary metabolites, unlike the primary form, and grew more rapidly than the primary form. A protocol for screening primary cultures of X. luminescens for secondary forms is presented.
Nanotube/Polymer Composites: Materials Selection and Process Design (2004)

Abstract : The objectives of this project were (1) establish proof of principle by demonstrating enhanced polymer properties by the addition of single walled nanotubes (SWNTs), (2) provide guidelines for materials selection that give improved mechanical, electrical and/or thermal properties, and (3) define processing methods most appropriate for the materials identified. Our study of SWNT-polymer composites focuses on thermoplastics, because these materials can be readily drawn into fibers. As we have shown previously, the extensional flow exerted on the composite during fiber spinning aligns the SWNT to an unprecedented level. The anisotropic orientation of SWNT in these composite fibers provides an advantage when bolting for changes in macroscopic properties, particularly tensile strength. Composite processing and composite characterization received comparable effort in this project. Processing efforts include our coagulation method as well as in situ polymerization of nylon in the presence of well-dispersed SWNT. In addition to mechanical testing of the SWNT-thermoplastic fibers, we established methods for testing the electrical and thermal conductivity of these highly anisotropic materials. We used scattering methods for quantifying the extent of dispersion within the composites, a widely appreciated and long standing question in nanocomposites.
Multifunctional synchronized measurement network [power systems] (1998)

In 1992, the New York Power Authority (USA) and the other Empire State Electric Energy Research Corporation member electric utilities initiated the deployment of a network of power system synchronized measurement units using phasor measurement technology on the New York State high-voltage transmission system. This article defines the current and future status of the measurement network, featuring its harmonics measurement and disturbance monitoring.
2,4-Dinitrophenyl Ethers of the Alditols<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2,4-Dinitrophenyl Ethers of the Alditols1M. L. Wolfrom, B. O. Juliano, Madeline S. Toy, and A. ChaneyCite this: J. Am. Chem. Soc. 1959, 81, 6, 1446–1448Publication Date (Print):March 1, 1959Publication History Published online1 May 2002Published inissue 1 March 1959https://pubs.acs.org/doi/10.1021/ja01515a040https://doi.org/10.1021/ja01515a040research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of an improved wheel profile for a freight car. Theoretical justification (2018)

With the increasing loads on the axle and speeds, the increase in wear resistance and resistance to contact fatigue of the wheels is of particular importance. In part, this result was achieved using a standard profile according to GOST 10791–2011 with the use of more efficient spring suspension. A further reduction in the wear rate of both the rolling surface and the flange can be achieved by developing a new wheel profile. The authors have developed a technique that allows, based on theoretical calculations and experimental observations, to make the choice of the shape of the wheel profile, consistent with the profiles of the rails. The results of measurements of the wheels of cars of the model 12-9853 installed on bogies 18-9855 were used as the initial data, which were under controlled operation. The profile development consisted of four main stages: the choice of baseline data, the choice of the curvature of the rolling surface, the choice of the curvature of the transition section to the throttle, and the choice of the flange thickness and radius of the throttle in the transition zone to the rolling surface. The technique was used to develop a new wheel profile that differs from the profile according to GOST 10791–2011 in that the rolling surface is made with three conjugate radii, respectively from the wheel to the flange: 500, 325 and 87.5 mm. The flange throttle radius of the developed profile is 17 mm, the angle of inclination of the flange to the horizontal is 68°, and the thickness of the flange is 32.5 mm. A part of the wheel surface from the wheel to the outer part of the rim fully complies with GOST 10791–2011. Calculations showed that the contact zone of the wheel with the VNITsTT profile relative to the rail is shifted from the center to the flange and the contact area is larger. It was found that for the VNITsTT wheel profile the ratio of the semi-axes of the ellipse of contact spots is lower than for the profile according to GOST 10791–2011.
Four-Electron Reduction of Metal Sulfides by Alkynes and the Reversible Formation of Persulfides (1998)

Alkynes add to ReS4- to give unstable 1:1 adducts [ReS2(S2C2R2)]-, which have been observed in solution. These mononuclear dithiolenes [ReS2(S2C2R2)]- react further with ReS4- to give the persulfido complexes [(ReS)2(μ-S)(μ-S2)(S2C2R2)]2(μ-S)24-, as depicted in the equation. Overall, these transformations demonstrate that persulfide formation can be induced by reductants.
ChemInform Abstract: Coenzyme Models. Part 45. Synthesis of Atropisomeric Flavins and Their Novel Redox‐Induced Racemization. (1988)

Abstract The isoalloxazines (IV) and (VIII) as well as the 5‐carba analogues (XI) are prepared and their atropisomers are optically resolved by HPLC with optical purities of 87‐100% e.e.
Relationship Between Seizure Frequency and Functional Abnormalities in Limbic Network of Medial Temporal Lobe Epilepsy (2019)

<b>Background:</b> We compared resting-state functional connectivity (RSFC) among limbic and temporal lobe regions between patients with medial temporal lobe epilepsy (mTLE) and healthy control subjects to identify imaging evidence of functional networks related to seizure frequency, age of seizure onset, and duration of epilepsy. <b>Methods:</b> Twelve patients with drug-resistant, unilateral medial temporal lobe epilepsy and 12 healthy control subjects matched for age, sex, and handedness participated in the imaging experiments. We used network-based statistics to compare functional connectivity graphs in patients with mTLE and healthy controls to investigate the relationship between functional connectivity abnormalities and seizure frequency. <b>Results:</b> Among mTLE patients, we found functional network abnormalities throughout the limbic system, but primarily in the hemisphere ipsilateral to the seizure focus. The RSFCs between ipsilateral hypothalamus and ventral anterior cingulate cortex and between ipsilateral subiculum and contralateral posterior cingulate cortex were highly correlated with seizure frequency. <b>Discussion:</b> These findings suggest that in mTLE, changes in limbic networks ipsilateral to the epileptic focus are common. The pathological changes in connectivity between cingulate cortex, hypothalamus and subiculum ipsilateral to the seizure focus were correlated with increased seizure frequency.
Lawrence design first metatarsophalangeal prosthesis. A complication (1989)

A complication involving tibial sesamoid impingement within the hinge of the Lawrence first metatarsophalangeal implant is described. The authors believe that this particular problem may be accentuated by the Lawrence design, which preserves the sesamoid apparatus.
Internal Friction Behavior of Alumina Polycrystals with Engineered Grain Boundaries (2002)

Internal friction of alumina polycrystals with engineered grain boundaries was measured in the low frequency range of the torsional forced-vibration. The maximum shear stress amplitude was 50 MPa. Owing to the very high temperature reached during these experiments (1900 K), internal friction spectra could be detected which reveal new important features of the intrinsic rheological behavior of alumina grain boundaries. The monotonically rising internal friction background and the torsional creep behavior, both of a diffusive origin, were systematically characterized upon modifying the grain-boundary structure of alumina with the addition of selected cation dopants (e.g., Titanium and Lutetium). The combined characterizations of internal friction spectrum and torsional creep rate enabled us to precisely assess the role of different cation dopants on “locking” or promoting the diffusive grain-boundary flow, which governs polycrystal deformation.
Muti-joule non-collinear OPCPA at 800nm in yttrium calcium oxyborate (2013)

The non-collinear optical parametric chirped pulse amplification in yttrium calcium oxyborate was experimentally demonstrated. The amplified energy of 3.36J centered at 800nm was generated with pump of 35J. After compression, the pulse duration was 44.3fs.
Hybrid single nanowire photonic crystal structure (2006)

We combine chemically-synthesized single nanowire emitters with lithographically-defined photonic crystal structures. Localized emission from engineered defects and light suppression in regions of the photonic crystal are demonstrated by photoluminescence imaging and spectroscopy measurements.
Bright Electrogenerated Chemiluminescence of a Bis‐Donor Quadrupolar Spirofluorene Dye and Its Nanoparticles (2016)

A series of symmetric fluorescent dyes built from a spirofluorene core bearing electroactive end groups and having different conjugated linkers were prepared with a view to their use as building blocks for the preparation of electrochemiluminescent (ECL) dyes and nanoparticles. Their electrochemical, spectroelectrochemical, and ECL properties were first investigated in solution, and structure/activity relationships were derived. The electrochemical and ECL properties show drastic variation that could be tuned by means of the nature of the π-conjugated system, the end groups, and the core. In this series, highly fluorescent dye 1 based on a spirofluorene core and triphenylamine end groups connected via thiophene moieties shows the most promising and intriguing properties. Dye 1 is reversibly oxidized in three well-separated steps and generates a very intense and large ECL signal. Its ECL efficiency is 4.5 times higher than that of the reference compound [Ru(bpy)3 ](2+) (bpy=2,2'-bipyridine). This remarkably high efficiency is due to the very good stability of the higher oxidized states and it makes 1 a very bright organic ECL luminophore. In addition, thanks to its molecular structure, this dye retains fluorescence after nanoprecipitation in water, which leads to fluorescent organic nanoparticles (FONs). The redox behavior of these FONs shows oxidation waves consistent with the initial molecular species. Finally, ECL from FONs made of 1 was recorded in water and strong ECL nanoemitters are thus obtained.
Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin‐embedded human tissues (1991)

The immunoreactivity of OV-TL 12/30, a monoclonal anti-keratin 7 antibody (Mab), was investigated on frozen as well as paraffin-embedded human tissues. Its reactivity patterns were compared with another well-characterized monoclonal antibody to keratin 7 (RCK 105), and with broadly cross-reacting monoclonal (OV-TL 12/5) as well as polyclonal (pKer) keratin antisera. In frozen sections of normal and malignant human tissues both keratin 7 Mabs gave similar staining patterns. The immunoreactivity for OV-TL 12/30 and the polyclonal antibody (pKer) in tissue sections fixed in 4 per cent formalin or Bouin solution, was completely restored when pretreated with 0.1 per cent pronase, 0.1 per cent trypsin in phosphate-buffered saline (PBS) or with 0.5 per cent pepsin in 0.01 N HCl. Except for loss of immunoreactivity on human normal stomach surface epithelium and glandular mucous cells, Mab OV-TL 12/30 reacted strongly positive with essentially all those formalin- or Bouin-fixed paraffin-embedded tissues that had been shown to stain in non-fixed, frozen sections. In addition to the good correlation in human tissues, a complete correlation between the reactivity on frozen and paraffin-embedded human carcinomas (n = 86) was found as well. While both RCK 105 (anti-keratin 7) and OV-TL 12/5 (anti-keratin 5, 7, 14, 19) did not stain on paraffin-embedded sections, the polyclonal control antiserum (pKer) lost immunoreactivity in some cell types (e.g. mucous cells in compound glands, hepatocytes, pancreatic acinar cells, and proximal and distal convoluted tubules of the kidney). Our study shows that the keratin 7 Mab OV-TL 12/30 is an excellent marker for tumour histopathology since it is reactive in paraffin-embedded formalin-fixed human tissues.
Agonist and antagonist EMG activity of neck muscles during maximal isometric flexion and extension at different positions in young healthy men and women (2007)

The aim of this study was to compare maximal isometric torque and EMG activity of neck flexors and extensors in flexed and extended positions between men and women. Twenty four non-trained young healthy subjects (12 men vs. 12 women) performed maximal isometric neck flexion and extension within 30° around the neutral position in a sitting posture using a modified isokinetic dynamometer. Surface EMG activity of sternocleidomastoid, scalenus, paraspinal and upper trapezius muscles was recorded bilaterally. Men exhibited higher normalized-to-lean body weight torque than women mainly during neck flexion (44%, P<0.001) compared to extension (18%, P<0.05). In addition, torque increased from extended to flexed positions in women only(+17%, P<0.001). This was associated with a decrease in EMG of neck extensors and upper trapezius muscles (from 35% to 20% and from 18% to 7%, P< 0.001, respectively) without changes in agonistic activity of neck flexors with neck position. In contrast, men displayed similar torque and muscle activation level within 30° of range of motion around the neutral position for both directions. These findings demonstrate gender-specific differences in neck function that was probably linked to higher coactivation level in antagonist muscles (neck extensors) and stabilizers (upper trapezius muscles).
A unique mechanism of desensitization to lipolysis mediated by β<sub>3</sub>-adrenoceptor in rats with thermal injury (1999)

Thermal injury causes a hypermetabolic state associated with increased levels of catabolic hormones, but the molecular bases for the metabolic abnormalities are poorly understood. We investigated the lipolytic responses after beta(3)-adrenoceptor (beta(3)-AR) agonists and evaluated the associated changes in beta-AR and its downstream signaling molecules in adipocytes isolated from rats with thermal injury. Maximal lipolytic responses to a specific beta(3)-AR agonist, BRL-37344, were significantly attenuated at post burn days (PBD) 3 and 7. Despite significant reduction of the cell surface beta(3)-AR number and its mRNA at PBD 3 and 7, BRL-37344 and forskolin-stimulated cAMP levels were not decreased. Glycerol production in response to dibutyryl cAMP, a direct stimulant of hormone-sensitive lipase (HSL) via protein kinase A (PKA), was significantly attenuated. Although immunoblot analysis indicated no differences in the expression and activity of PKA or in the expression of HSL, HSL activity showed significant reductions. Finally, beta(3)-AR-induced insulin secretion was indeed attenuated in vivo. These studies indicate that the beta(3)-AR system is desensitized after burns, both in the adipocytes and in beta(3)-AR-induced secretion of insulin. Furthermore, these data suggest a complex and unique mechanism underlying the altered signaling of lipolysis at the level of HSL in animals after burns.
Vanadium(III)-.alpha.-amino acid homoleptic complexes from nonprotic solutions: reactions of [V(Mes)3(THF)] with .alpha.-amino acids and the structures of tris(L-prolinato)vanadium-dimethyl sulfoxide and tris(D-prolinato)vanadium-dimethyl sulfoxide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVanadium(III)-.alpha.-amino acid homoleptic complexes from nonprotic solutions: reactions of [V(Mes)3(THF)] with .alpha.-amino acids and the structures of tris(L-prolinato)vanadium-dimethyl sulfoxide and tris(D-prolinato)vanadium-dimethyl sulfoxideC. Philippe Magill, Carlo Floriani, Angiola Chiesi-Villa, and Corrado RizzoliCite this: Inorg. Chem. 1993, 32, 12, 2729–2735Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ic00064a025https://doi.org/10.1021/ic00064a025research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Paramyotonia congenita and hyperkalemic periodic paralysis map to the same sodium-channel gene locus. (1991)

Paramyotonia congenita (PC), an autosomal dominant muscle disease, shares some clinical and electrophysiological similarities with another myotonic muscle disorder, hyperkalemic periodic paralysis (HYPP). However, clinical and electrophysiologic differences allow differentiation of the two disorders. The HYPP locus was recently shown to be linked to a skeletal muscle sodium-channel gene probe. We now report that PC maps to the same locus (LOD score 4.4, theta = 0 at assumed penetrance of .95). These linkage results, coupled with physiological data demonstrating abnormal sodium-channel function in patients with PC, implicate a sodium-channel gene as an important candidate for the site of mutation responsible for PC. Furthermore, this is strong evidence for the hypothesis that PC and HYPP are allelic disorders.
Preface to ISIF 2009 Special Issue of Journal of Applied Physics: Science and Technology of Integrated Functionalities (2011)

First Page
Infinite stacking of alternating polyfluoroaryl rings and bromide anions (2013)

The crystal structure of 1-(4-bromo-2,3,5,6-tetrafluorophenyl)-3-benzylimidazolium bromide comprises columns of parallel bromotetrafluorophenyl rings with an interplanar distance of 6.936(6) Å separated by bromide anions.
Built-in optical angular position sensing mechanism for high-resolution vibratory grating scanner (2011)

A built-in angular sensing mechanism unique to the vibratory grating scanner is demonstrated through utilizing the zeroth-order beam, of which the intensity variation is affected by the angular position of the grating platform. With the first-order diffracted beam used for optical scanning, the stationary zeroth-order beam can be used for angular position sensing.
ChemInform Abstract: Mixed Lineage Kinase Activity on Indolocarbazole Analogues. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hydrothiophosphorylation of Vinyl Sulfoxides: First Examples (2005)

The first examples of facile hydrothiophosphorylation of organyl vinyl sulfoxides are described. Nucleophilic addition of P,S-ambident secondary phosphine sulfides 1 and 2 to organyl vinyl sulfoxides 3-6 with potassium hydroxide at room temperature proceeds chemo- and regioselectively to give the corresponding bis(2-organylethyl)[2-(organylsulfinyl)ethyl]phosphine sulfides 7a-e in high isolated yields.