gebhart/patrepeval huggingface dataset:
Autocapture compatibility in patients with the MembraneEX lead and Affinity pulse generators (2001)

The first Autocapture generation worked well with all recommended leads. The newer Autocapture generation provides a more sensitive resolution for evoked response testing and its implementation in a dual-chamber device. The purpose of the study was to evaluate the performance of the Affinity SR/DR pacemaker with the new Autocapture algorithm in combination with the small surface area pacing lead MembraneEX in 129 patients. Autocapture ventricular threshold, sensing threshold, lead impedance, evoked response (ER) and polarization signals were determined at implantation and discharge, as well as after 1 and 3 months. Autocapture recommendation rate was based on the ER sensitivity test. The median pacing threshold was 0.38, 0.50, 0.75, 0.75 V at implant, discharge, 1 and 3 months post-implant, respectively. The respective data for median lead impedance were 744, 605, 649 and 691 ohms; median sensing threshold was 12.5 mV at all visits. The median ER amplitude was 9.0, 10.1, 9.9 and 10.1 mV and the median polarization signal 0.39 mV at all visits. The frequency of recommended Autocapture activation was 98.3%, 99.2%, 98.3% and 96.2% of all patients at implant, at discharge, 1 and 3 months post-implant respectively. In conclusion, the studied pulse generator enabled, in combination with this pacing lead, in >95% of all patients activation of Autocapture.
Low Phase Noise <i>G</i>$ _{m}$-Boosted Differential Gate-to-Source Feedback Colpitts CMOS VCO (2009)

This paper presents a <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> -boosted differential gate-to-source feedback Colpitts (GS-Colpitts) CMOS voltage-controlled oscillator (VCO) that consumes a lower oscillation start-up current. The proposed architecture allows a wider range of saturation mode operation for the switching transistors, which helps suppress AM-to-FM conversion by these transistors. In addition, the phase noise contribution of the flicker noise in the switching transistor is reduced through the capacitor feedback network of the Colpitts oscillator. As a result, the proposed topology can achieve better phase noise performance and a higher figure of merit (FOM) compared to a conventional NMOS-only cross-coupled VCO. The proposed VCO is implemented in a 0.18-mum CMOS for 1.78 to 1.93 GHz operation. At 1.86 GHz, the measurements show phase noise of -105 and -128 dBc/Hz (corresponding to FOM = 191.2) at offsets of 100 kHz and 1 MHz, respectively, while dissipating 1.8 mA from a 0.9-V supply.
Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications (2014)

Imidazo[1,2-a]pyrazine acts as a versatile scaffold in organic synthesis and drug development. This review article is an effort to compile the progress made in synthetic methods and to illustrate its reactivity and multifarious biological activity. This review is mainly based on the pattern and position of the substitution, and should help the scientific community to bring about future developments.
FASTING AND REFEEDING: CELL KINETIC RESPONSE OF JEJUNUM, ILEUM AND COLON (1977)

Following a period of fasting, feeding a normal diet results in a burst of DNA synthesis in the crypts of the colonic epithelium. This is due largely to a prompt entry of cells, blocked in G1, into S. Peak levels of S cellularity exceed 4 times the fasting, and 2 times the normal fed control values. Refeeding a low residue diet (soluble casien, glucose and corn oil) results in a return to control levels of proliferative activity, but no hyperplasia. However, in jejunum and ileum, refeeding is followed by a return to near control levels of proliferation with only a slight overshoot in S phase cellularity. During the fasting period, the ileal crypt proliferative compartment (Pc-zone) and total crypt cellularity decline significantly. These changes are accompanied by an increase in the total cycle time, due to an equivalent lengthening of the G1 and S phase. Following refeeding, there is a reduction in the cycle time and a gradual return to the control values for the Pc-zone size and cellularity. In the colon, fasting has no effect on the Pc-zone size or total crypt cellularity. There is an approximate doubling of the cycle time due solely to an increase in G1. Following refeeding there is an increase in the Pc-zone size and crypt cellularity and a marked shortening of the cycle time. Evidence that a G1 cycle blockade is induced in the colon by fasting is given by a lenghening of the G1 period and by stathmokinetic studies employing vincristine.
Thermogenesis in Muscle (1994)

Mitochondrial fatty acid β-oxidation (FAO) is the major pathway for the degradation of fatty acids and is essential for maintaining energy homeostasis in the human body. Fatty acids are a crucial energy source in the postabsorptive and fasted states when ...Read More
Fine-tuning time in the space age (1998)

The precise knowledge of the correct time on which much of modern society depends relies on Coordinated Universal Time (UTC), distributed by the satellites of the Global Positioning System. This paper describes how UTC is but just the latest step in the long evolution of time standards.
Nitrate Removal From Drinking Water—Review (1997)

Nitrate concentrations in surface water and especially in ground water have increased in Canada, the United States, Europe, and other areas of the world. This trend has raised concern because nitrates cause methemoglobinemia in infants. Several treatment processes including ion exchange, biological denitrification, chemical denitrification, reverse osmosis, electrodialysis, and catalytic denitrification can remove nitrates from water with varying degrees of efficiency, cost, and ease of operation. Available technical data, experience, and economics indicate that ion exchange and biological denitrification are more acceptable for nitrate removal than reverse osmosis. Ion exchange is more viable for ground water while biological denitrification is the preferred alternative for surface water. This paper reviews the developments in the field of nitrate removal processes.
A methodology for designing aircraft to low sonic boom constraints (1991)

A method for designing conceptual supersonic cruise aircraft to meet low sonic boom requirements is outlined and described. The aircraft design is guided through a systematic evolution from initial three view drawing to a final numerical model description, while the designer using the method controls the integration of low sonic boom, high supersonic aerodynamic efficiency, adequate low speed handling, and reasonable structure and materials technologies. Some experience in preliminary aircraft design and in the use of various analytical and numerical codes is required for integrating the volume and lift requirements throughout the design process.
Enumeration of Mucus‐Containing Cells, Mast Cells and Eosinophils in Nasal Smears From Atopic Children (1979)

Kemp, A. S., and Holsman, P. D. (1979). Aust. Paediatr. J. , 15, 166–167. Enumeration of mucus‐containing cells, mast cells and eosinophils in nasal smears from atropic children. The nasal smear cyctology from a group of immediate hypersensitivity skin test positive children with the symptom of recurrent wheeze was compared with that of a group of skin test negative children. Mucus‐containing cells, eosinophils and mast cells were quantitated. Eighteen of the twenty smears from the skin test positive children showed increased numbers of at least one cell type. It is concluded that abnormal nasal cytology is a common finding in atopic children with recurrent wheeze and that nasal pathology may be reflected in increased numbers of mucus‐containing cells, mast cells or eosinophils.
An Escherichia coli homologue of eukaryotic potassium channel proteins. (1994)

A DNA sequence in Escherichia coli K-12 contains an evident gene, kch, which predicts a protein 417 residues long with extensive similarity to a group of eukaryotic potassium channel proteins in amino acid sequence, in the presence of six apparent transmembrane (S) regions, and in the potassium-specific P (or H5) "pore" region found between S5 and S6. Most of the kch gene, including all of these regions and the 5' flanking region, have been sequenced in 38 wild reference (ECOR) strains as well; variation is conservative, indicating the protein's importance to the species, possibly as a defense against osmotic shock. Since the major family of eukaryotic potassium channel proteins is thought to have evolved from a common ancestor, the evolutionary position of this evident bacterial homologue is of interest, particularly since its function may have changed less than those of eukaryotic channels in the last billion years. While cases of probable importation of eukaryotic genes into bacteria are known, there is no evidence that kch has been imported. The relevant properties of the Kch protein and further ways to investigate its evolutionary position are discussed.
Learning from HSV-infected mice as a model of Behçet's disease. (2013)

Several animal models of Behçet's disease (BD) have been proposed according to putative etiology. Among these models, the herpes simplex virus (HSV)-induced model produced the most similar disease attributes observe in patients. Inoculation of HSV type 1 to the scratched earlobe of mice produced the appropriate symptoms, including oral, genital, and skin ulcers, eye lesions, arthritis, and intestinal involvement. This HSV-induced BD model is the only continuously used model, to which various therapeutic modalities have been applied.
Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2 (1998)

Cytosolic phospholipase A2 (cPLA2) is a calcium-sensitive 85-kDa enzyme that hydrolyzes arachidonic acid-containing membrane phospholipids to initiate the biosynthesis of eicosanoids and platelet-activating factor, potent inflammatory mediators. The calcium-dependent activation of the enzyme is mediated by an N-terminal C2 domain, which is responsible for calcium-dependent translocation of the enzyme to membranes and that enables the intact enzyme to hydrolyze membrane-resident substrates. The 2.4-A x-ray crystal structure of this C2 domain was solved by multiple isomorphous replacement and reveals a beta-sandwich with the same topology as the C2 domain from phosphoinositide-specific phospholipase C delta 1. Two clusters of exposed hydrophobic residues surround two adjacent calcium binding sites. This region, along with an adjoining strip of basic residues, appear to constitute the membrane binding motif. The structure provides a striking insight into the relative importance of hydrophobic and electrostatic components of membrane binding for cPLA2. Although hydrophobic interactions predominate for cPLA2, for other C2 domains such as in "conventional" protein kinase C and synaptotagmins, electrostatic forces prevail.
Concurrent management of postprandial glycaemia and nutrient intake using glycaemic glucose equivalents, food composition data and computer‐assisted meal design (2000)

A computer system, called SERVE-NZ Nutririon Management System, for use in diabetes management, addresses the problem of concurrently controlling postprandial glycaemic response and nutrient intake in meals containing a number of foods, is described. It converts the weight and relative glycaemic potency of each food to its content of glycaemic glucose equivalents (GGE) - the amount of glucose theoretically inducing the same blood glucose response as would the specified quantity of food. Glycaemic glucose equivalents in a meal can be simply obtained by adding the GGE content of all foods in the meal to give a figure for the maximal glycaemic impact of the meal. Glycaemic glucose equivalents may be calculated using food composition databases that include available carbohydrate, common standard measure weights and glycaemic index values. If GGE is treated as a nutrient, an output of the total nutrient profile of a food or meal, and its glycaemic impact as GGE, can be obtained simultaneously. Application of a nutritional software system incorporating GGE values to management of glycaemic loadings and nutrient intakes over five meals within a day is demonstrated. The system may be a useful aid in self-management of glycaemia, as it will identify quantities of foods that can be consumed without exceeding the predetermined glucose tolerances of individuals. The graphical presentation of GGE and nutrient composition of meals may be a useful visual aid in educating clients with diabetes. The GGE values on food labels would provide easily understood guidance, not obtained from glycaemic index values, to the maximum number of items or quantity of a food that an individual should eat at a time. In its present basic form the calculation of GGE is most likely to slightly overestimate glycaemic impact, so it presents a worst-case prediction.
Using a coordination language to specify and analyze systems containing mobile components (2000)

New computing paradigms for network-aware applications need specification languages able to deal with the features of mobile code-based systems. A coordination language provides a formal framework in which the interaction of active entities can be expressed. A coordination language deals with the creation and destruction of code or complex agents, their communication activites, as well as their distribution and mobility in space. We show how the coordination language PoliS offers a flexible basis for the description and the automatic analysis of architectures of systems including mobile entities. Polis is based on multiple tuple spaces and offers a basis for defining, studying, and controlling mobility as it allows decoupling mobile entities from their environments both in space and in time. The pattern-matching mechanism adopted for communication helps in abstracting from addressing issues. We have developed a model-checking technique for the automatic analysis of PoliS specifications. In the article we show how this technique can be applied to mobile code-based systems
THE CHANGING IMPORTANCE OF STRUCTURAL HOLES AND SOCIAL CAPITAL IN AN EMERGING INDUSTRY: EVIDENCE FROM THE INTERNET INDUSTRY (2006)

Although there is substantial agreement on the importance of firm networks and social capital for new startup firms, there has been little work examining how they develop in an emerging industry and how they change over time. To answer these questions, we examine changes in the firm networks of a sample of leading US Internet firms over the period 1990-2000. Our results suggest that new firms exploit structural holes during early phase of industry but that social capital becomes increasingly important as the industry matures.
The Network Educational Resources Construction on Meteorology Based on Data Mining (2015)

With the vigorous development of the modern network education technology, the construction of network resource developed towards digital, intelligent and personalized, in order to satisfy the distance learners of different learning needs. By analyzing the problems currently learners in the use of the repository for learning generated by the proposed use of data mining techniques to further planning and construction of the repository, and on how to improve the organizational structure of the repository, and improve the utilization of the repository, personalized to meet the current in-depth research and analysis of learning problems.
A General Framework for Hardware Trojan Detection in Digital Circuits by Statistical Learning Algorithms (2016)

The continuous globalization of the semiconductor industry has significantly raised the vulnerability of chips under hardware Trojan (HT) attacks. It is extremely challenging to detect HTs in fabricated chips due to the existence of process variations (PVs), since PVs may cause larger impacts than HTs. In this paper, we propose a novel framework for HT detection in digital integrated circuits. The goal of this paper is to detect HTs inserted during fabrication. The HT detection problem is formulated as an under-determined linear system by a sparse gate profiling technique, and the existence of HTs is mapped to the sparse solution of the linear system. A Bayesian inference-based calibration technique is proposed to recover PVs for each chip for the sparse gate profiling technique. A batch of under-determined linear systems are solved together by the well-studied simultaneous orthogonal matching pursuit algorithm to get their common sparse solution. Experimental results show that even under big measurement errors, the proposed framework gets quite high HT detection rates with low measurement cost.
Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates (1994)

The feasibility of developing biodegradable polymer scaffolds to engineer tissues was investigated by studying the effects of pore size on the dynamics of fibrovascular tissue ingrowth. Tissue advanced into amorphous poly(L-lactic acid) porous substrates faster as the pore diameter increased. Porous cylindrical devices of 13.5 mm diameter, 5 mm thickness, and approximately 500 microns pore size were filled completely by tissue 5 days postimplantation. Although prevascularized devices possessed minimal void volume for cell seeding to regenerate metabolic organs, they hold promise in the regeneration of tubular tissues by relying on the epithelization of prevascularized grafts.
Kinetic and e.p.r. studies on the inhibition of xanthine oxidase by alloxanthine (1 <i>H</i>-pyrazolo [3, 4-d] pyrimidine-4,6-diol) (1981)

The inhibition by alloxanthine of oxidation of xanthine by xanthine oxidase is characterized by a prolonged transient phase. Kinetic data accord with a mechanism that involves rapid formation of a reduced enzyme-alloxanthine complex that subsequently undergoes a relatively slow-reversible reaction. In this scheme the slowly formed complex cannot be fully reoxidized by oxygen. From the Ki value for the dissociation of alloxanthine from the rapidly formed complex (1.15 microM) and values of 0.37 min-1 and 0.011 min-1 for the forward and reverse rate constants of the slow reaction, an overall inhibition constant for alloxanthine of 35 nM was calculated. A molybdenum (V) e.p.r. signal from the slowly formed reduced enzyme-alloxanthine complex is described. The rate of appearance of this new signal is consistent with this assignment. The signal (the "Alloxanthine signal") was simulated with g1 2,0269, g2 1,9593, g3 11.9444 and shows indications of hyperfine coupling to nitrogen. Similarities between it and the Very Rapid signal are discussed. Close structural analogies between the catalytic intermediate represented by the Very Rapid signal and the inhibitor complex represented by the Alloxanthine signal are suggested.
Critical issue for business area impact analysis in business crisis management: analytical capability (1999)

Crisis management and organizational continuity have become increasingly critical areas of competence for managers in organizations. The approach of typical business organizations to the problems of business area impact analysis (BAIA) has been fragmented. In particular, the potential problem is the lack of an analytical capability to identify business functions/processes. The research objective is to describe how business functions/processes can be identified to analyze business area impact for corporate crisis management. In order to conduct the BAIA efficiently, it is first necessary to identify business functions/processes according to a scientific approach such as that described in the Information Engineering methodology for systems development. Next, to investigate the financial impacts on business functions/processes, which level of function/process hierarchy decomposition is used as a basis must be determined.
Computed Tomography Biomarkers of Pulmonary Emphysema (2013)

The use of computed tomography (CT) scanning to assess emphysema has exploded since the mid-1980s. Since the definition of emphysema, permanent enlargement of airspaces and destruction of alveolar ...
Nitrogen Compounds of the Phosphoric and Phosphonic Acids. IV. Some Derivatives of Phenylphosphonamidic and Phenylphosphonamidothioic Acids (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrogen Compounds of the Phosphoric and Phosphonic Acids. IV. Some Derivatives of Phenylphosphonamidic and Phenylphosphonamidothioic AcidsM. F. HERSMAN and L. F. AUDRIETHCite this: J. Org. Chem. 1958, 23, 12, 1889–1893Publication Date (Print):December 1, 1958Publication History Published online1 May 2002Published inissue 1 December 1958https://pubs.acs.org/doi/10.1021/jo01106a017https://doi.org/10.1021/jo01106a017research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparative Study on the Relationship between Equity Incentive and Its Performance for the Board and TMT Members——Analysis Based on Panel Data of Listed Companies on SME Board (2008)

This paper compares the incentive effects after the positive test on the relationship between equity incentive and its performance for the board and TMT member of listed companies on SME board.As the results show,the equity incentive and its performance has significantly positive correlation.And the incentive effects of TMT are more significant than the board.So companies should strengthen the incentive to TMT member to improve the incentive effects.The results also show that equity incentive and its performance has significantly quartic correlation.And it calculates the inflexion of stake proportion of equity incentive.The proportion of equity incentive to TMT is 19.72%and 45.55%,and the proportion to the board is 25.73%and 52.73%.