gebhart/patrepeval huggingface dataset:
Medical therapies for amyotrophic lateral sclerosis-related respiratory decline: an appraisal of needs, opportunities and obstacles (2021)

A roundtable convened in July 2020 examined issues concerning respiratory support in amyotrophic lateral sclerosis (ALS), with reference to the potential for an early-phase orally administered medication that might either postpone the introduction of noninvasive ventilation (NIV) and/or enhance the benefits to be gained from it. Attention was also given to the impact of the COVID-19 pandemic on usual practice in the assessment and management of ALS-related respiratory difficulties. Implementation of NIV marks a step-change in clinical status for patients and a major increase in burden for caregivers. All means to ease this transition should be explored: an oral therapy that supported respiratory function and patients' independence and sense of well-being would aid discussions to facilitate the eventual successful introduction of NIV. Assessment of a candidate oral therapy that might support respiratory function in ALS patients would be aided by the development of improved patient-reported outcome measures for robust quantification of treatment effect and quality of life. Such instruments could also be used to monitor patients' status during the COVID-19 pandemic, averting some of the risks of face-to-face assessment plus the patient burden and costs of traditional methods. Several oral candidate therapies have recently failed to meet their primary endpoints in clinical trials. However, understanding of the underlying physiology and appropriate trial design have grown and will inform future developments in this field.
Rice Blast Controlling Activities of Bis (alkoxycarbonyl) ketene dithioacetals and their Related Compounds (1976)

マロン酸エステルと二硫化炭素を塩基の存在下で反応させ, 得られる置換エチレンジチオールをアルキル化, あるいは環化させて多数の誘導体を合成し, それらのイネいもち病防除活性をポット植の稲を用いて評価した. イネいもち病に対し, 治療的, 予防的, 持続的効果の判定のほかに水面施用的な活性を検討し, 化合物の浸透移行性を評価した.S, S′-ジ置換体のなかには茎葉散布的には優れた活性を示すものも見られたが, 浸透移行性に欠けた. S, S′-閉環誘導体のうちでは, 1, 3-ジチオラン型の化合物にのみ優れた活性が発現した. 多数の1, 3-ジチオラン誘導体のなかで, diisopropyl 1, 3-dithiolan-2-ylidenmalonate が効果の持続性, 浸透移行性の点から最も優れていた.
IR laser-assisted micro/nano-imprinting (2006)

We report on the development of a new imprint method capable of transferring patterns down to nano-sized features from a silicon mold assisted by an infrared pulse laser during imprinting. We demonstrate that successful pattern transfer can be achieved easily on photoresist films of SU-8 5 from a silicon mold with a feature size of either 5 ?m or 266 nm using a 1064 nm Nd:YAG laser. It is found that the IR pulse laser energy is absorbed predominantly by the silicon mold, and the pattern transfer is completed through heat transfer to the polymer. We also find that large area imprinting over 4 mm2 and pattern transfer with concave features can be achieved by taking advantage of flexible Si mold fabrication. This method integrates strengths from hot embossing and laser-assisted direct imprinting. The rapid imprint speed and variety of three-dimensional structures available in silicon technology render this technique a strong candidate for many real-world applications.
ChemInform Abstract: DIE RK. VON CHINAZOLIN MIT AKTIVIERTEN METHYLENVERBINDUNGEN (1972)

Abstract Die Umsetzung von Chinazolin (I) mit den Methylenverbindungen (II) in Gegenwart von Methylat bei Raumtemperatur ergibt 4,4′‐Bi‐chinazolin (III) und die Kondensationsprodukte (IV).
Glycolipids of Fungi and Plants (1977)

Conference Article| December 01 1977 Glycolipids of Fungi and Plants JOHN L. HARWOOD JOHN L. HARWOOD 1Department of Biochemistry, University College, P.O. Box 78, Cardiff CF1 1 XL, Wales, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1977) 5 (6): 1677–1682. https://doi.org/10.1042/bst0051677 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation JOHN L. HARWOOD; Glycolipids of Fungi and Plants. Biochem Soc Trans 1 December 1977; 5 (6): 1677–1682. doi: https://doi.org/10.1042/bst0051677 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1977 Biochemical Society1977 Article PDF first page preview Close Modal You do not currently have access to this content.
AVAILABILITY OF PHOSPHORUS FROM 17 ROCK PHOSPHATES IN MODERATELY AND WEAKLY ACIDIC SOILS AS DETERMINED BY 32P DILUTION, A VALUE, AND TOTAL P UPTAKE METHODS (1984)

We used isotope dilution, A value determination, and total P uptake methods to measure the effectiveness of 17 rock phosphates as sources of phosphorus for wheat, following direct application to moderately and slightly acidic soils. The measured P uptake values were compared with values determined by chemical extraction methods used to predict availability of rock phosphates. Tracer techniques provided more reliable indexes of availability than did the nontracer method and were more highly correlated with chemical extraction measurements. The most effective rock phosphate was approximately 88% as effective as triple superphosphate (TSP) in the moderately acidic soil and 68% as effective as TSP in the slightly acidic soil when rock phosphate was added at 10 times the TSP rate. Several rock phosphates had no positive effect on wheat growth or P uptake. The main advantage of the isotope dilution method over A value determinations is that inexpensive ortho 32P is used instead of specially labeled phosphate compounds. Other advantages are discussed.
THE HEPARINIZED CAPILLARY TUBE AS AN EPIDEMIOLOGIC TOOL (1964)

THE HEPARINIZED CAPILLARY TUBE AS AN EPIDEMIOLOGIC TOOL: II. CONCENTRATION OF BLOOD PARASITES BY CENTRIFUGATION Get access ROBERT M. WORTH ROBERT M. WORTH From the Department of Public Health, University of HawaiiHonolulu, Hawaii Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 80, Issue 1, July 1964, Pages 70–74, https://doi.org/10.1093/oxfordjournals.aje.a120460 Published: 01 July 1964 Article history Received: 03 February 1964 Published: 01 July 1964
Methods For Estimating The Atmospheric Radiation Release From The Fukushima Dai-Ichi Nuclear Power Plant (2012)

CORRESPONDING AUTHOR: Paul E. Bieringer, National Center for Atmospheric Research, 3450 Mitchell Lane, Boulder, CO 80301, E-mail: paulb@ucar.edu
Hydrotalcite-derived mixed oxides containing copper: catalysts for the removal of nitric oxide (1996)

Hydrotalcite structures containing copper, magnesium and aluminium in the metal hydroxide layers have been investigated for their potential as precursors to the formation of catalysts for the decomposition and reduction of nitrogen oxides. These CuIIMgIIAlIII hydrotalcites are catalytically active towards both the decomposition of nitric oxide and its reduction in the presence of an appropriate coreductant, such as propane. The copper centred active species, identified using EXAFS spectroscopy and combined EXAFS/XRD under operating conditions, have been found to be CuI for the decomposition and Cu0 for the reduction.
Economics of adding fat and increasing lysine:calorie ratio in diets for growing-finishing gilts (1999)

A total of 1,200 gilts was used to evaluate the economics ofadding fat and increasing lysine:calorie ratio in diets for growing-finishing pigs. Diets were fed in four phases and consisted of a 2 x 4 factorial arrangement with two levels of fat (0 and 6%) and four increasing lysine:calorie ratios. Eight economic scenarios combining com, soybean meal, fat, and hog prices with two packer grading systems were created. Stochastic dominance analysis was performed on 64 alternatives (8 treatments x 8 scenarios). The third "and fourth (higher) lysine: calorie ratios increased income over feed cost when fat was added to the diets, except for the high fat price scenario in which the fourth lysine:calorie ratio without added fat dominated. The first two (lower) lysine: calorie ratios were inferior under all scenarios.; Swine Day, Manhattan, KS, November 18, 1999
Attenuation of A/chicken/Kurgan/3/2005 (H5N1) influenza virus using selection in an environment simulating the life cycle of wild duck viruses (2011)

The highly pathogenic A/chicken/Kurgan/3/2005, (K/05) H5N1 influenza virus was attenuated using selection in an environment simulating the life cycle of wild duck influenza viruses. The goal of this work was the selection of viruses which are more stable for protease cleavage and low pH than the parent virus. The attenuated virus (K/at) was nonpathogenic for mice and did not induce mortality in embryonated chicken eggs. The pH of K/at hemagglutinin conformational change decreased by 0.45–0.50 units compared with the initial K/05 virus. K/at increased the affinity for fucosylated receptors in contrast to K/05. The total sequencing and analysis of the viral genome identified ten amino acid substitutions (1 in PB2, PB1, NP, and NS1; 2 in NA; and 4 in HA) in K/at relative to the initial K/05 located in functionally important regions. K/at substitutions Asp54Asn in HA1 and Val48Ile in HA2 in hemagglutinine are the reverses to the sequence characteristic of wild duck viruses. These substitutions, like the substitution Lys131Thr in HA2, change the mobility of molecules and can influence the parameters of conformation transition of hemagglutinin. The fourth substitution in HA1 Lys222Thr was located in the region of interaction with the receptor. Substitutions in NS1 (Arg37His) and PB1 (Leu218Met) were identified in the region of nuclear localization signal, and mutations in proteins PB2 (Asp256Asn) and NP (Trp386Cys) were located at sites involved in the transcription and replication of the viral genome.
The Polypyrimidine Tract-binding Protein Is Required for Efficient Dengue Virus Propagation and Associates with the Viral Replication Machinery (2009)

The polypyrimidine tract-binding protein (PTB) functions primarily as an IRES trans-acting factor in the propagation of hepatitis C virus and picornaviruses. PTB interacts with secondary structures within the 3'- and 5'-untranslated regions of these viral genomes to mediate efficient IRES-mediated viral translation. PTB has also been reported to bind to the untranslated region of the single-stranded RNA dengue virus (DENV), suggesting a similar function for PTB in flaviviruses. Indeed small interfering RNA-mediated PTB knockdown inhibited the production of infectious DENV, and this inhibition was specific to PTB knockdown and not due to a nonspecific anti-viral state. In fact, PTB depletion did not inhibit the production infectious yellow fever virus, another flavivirus. Nevertheless, whereas PTB knockdown led to a significant decrease in the accumulation of DENV viral RNAs, it did not impair translation. Moreover, PTB was shown to interact with the DENV nonstructural 4A protein, a known component of the viral replication complex, and with the DENV genome during infection. These data suggest that PTB interacts with the replication complex of DENV and is acting at the level of viral RNA replication.
Erratum to “GPU Accelerated Atomistic Energy Barrier Calculations of Skyrmion Annihilations” (2019)

Equations (1) and (7) in the original publication [1] exhibit a wrong sign for the dipole-dipole interaction. Equation (1) should have been written as
Ammine(trimethyl)aluminum formation and pyrolytic methane loss: thermodynamics, kinetics, and mechanism (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmmine(trimethyl)aluminum formation and pyrolytic methane loss: thermodynamics, kinetics, and mechanismFrederick C. Sauls, Leonard V. Interrante, and Zhiping JiangCite this: Inorg. Chem. 1990, 29, 16, 2989–2996Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/ic00341a028https://doi.org/10.1021/ic00341a028research-articleACS PublicationsRequest reuse permissionsArticle Views268Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mapping and Ablation in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (2019)

This chapter summarizes the current knowledge of the cardiomyopathy with a particular emphasis on the electroanatomical abnormalities and mapping and ablation of ventricular arrhythmias in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). An ameliorated comprehension of electroanatomical substrate and the scar architecture underneath reveals that the epicardial involvement is consistently larger than endocardial. The technical aspects of map construction are similar to those for the endocardial strategy, except for the peculiar features that involve epicardial assessment as pericardial access and anatomical aspects such as coronary anatomy and epicardial fat voltage reading issues, which, by themselves, are important reasons for epicardial ablation failure. Techniques of epicardial mapping in ARVD/C are similar to mapping and ablation of ventricular tachycardia (VT) in non-ischemic cardiomyopathy. The unique pattern of scar distribution in the peritricuspid region results in reentrant circuits in this scar, and hence superior axis VTs with late precordial transition in V4 and V5.
Um mercanismo para escalonamento de pacotes no uplink da rede LTE no contexto da comunicação máquina-a-máquina (2013)

As redes celulares sao esperadas para desempenhar um importante papel no futuro da Internet das Coisas (Internet of Things - IoT) e na comunicacao Maquina-a-Maquina (Machine-to-Machine - M2M), com a rede LTE ganhando cada vez mais destaque tanto da academia quanto da industria na implantacao deste cenario. Contudo, melhorias na rede LTE sao necessarias devido as caracteristicas intrinsecas da comunicacao M2M, como a grande quantidade de dispositivos e a diversidade nos requerimentos das suas aplicacoes, que os diferenciam da comunicacao Humano-a-Humano (Human-to-Human - H2H) para a qual a rede foi inicialmente projetada. Dentre essas melhorias, esta o aperfeicoamento no escalonamento de pacotes no uplink definido no padrao para que trate o caso da comunicacao M2M e atenda aos seus requerimentos sem causar grandes impactos na comunicacao H2H. Este trabalho propoe um mecanismo para o escalonamento de pacotes no uplink da rede LTE no contexto da comunicacao M2M que utiliza as informacoes atuais e passadas da rede e de cada dispositivo para satisfazer os requisitos de Qualidade de Servico (QoS) dos dispositivos M2M, evitar o problema de inanicao e controlar o congestionamento causado por estes dispositivos. Os resultados obtidos indicam que a proposta consegue reduzir o impacto da comunicacao M2M sobre a H2H e garantir justica na alocacao de recursos. No entanto, o nivel de satisfacao dos requisitos de QoS dos dispositivos M2M diminui com o aumento do trafego H2H.
Coarsening of capillary drops coupled by conduit networks (2010)

A system of n spherical-cap drops, coupled by a network of conduits, coarsens due to surface tension forces. The total interfacial energy drives the fluid through the conduits such that, with time, the volume becomes increasingly localized into fewer large drops. The coarsening rate is predicted heuristically for drops coupled by orthogonal networks, a porous medium, and fractal networks of various dimensions. The predicted coarsening law as it depends upon the type and dimension of network, total number of drops, and initial drop volume is compared against numerical simulations of large n . Additionally, distributions of large drop volumes are obtained using a Lifshitz-Slyozov-Wagner (LSW) model. The predicted distributions are independent of network topology; in contrast, simulation results depend weakly on the network dimension. The heuristic coarsening rate laws are recovered using the LSW model for all but a square network topology.
On the Sol-Gel Preparation and Characterization of LanthanideAluminium Garnets (2008)

Sol-Gel Preparation and Characterization of Lanthanide
Aluminium Garnets Ce3Al5O12, Pr3Al5O12, Nd3Al5O12, Tb3Al5O12,
Dy3Al5O12, Er3Al5O12
Invasive Pulmonary Infection Due to<i>Trichoderma longibrachiatum</i>Mimicking Invasive Aspergillosis in a Neutropenic Patient Successfully Treated with Voriconazole Combined with Caspofungin (2008)

Trichoderma longibrachiatum, a filamentous fungus, was recently described as an emerging pathogen in immunocompromised patients. Here, we report the first case, to our knowledge, of isolated invasive lung infection by T. longibrachiatum in a patient with hematologic malignancy. The infection mimicked invasive pulmonary aspergillosis and was successfully treated with a combination of voriconazole and caspofungin.
A Multi-stage Approach For Building And Hvac Model Validation And Its Application To A Swiss Office Building (2013)

In the Swiss research project OptiControl (www.opticontrol.ethz.ch), new predictive building control strategies are developed and applied to a fully occupied, well instrumented demonstrator building. Here we report on the development and validation of the EnergyPlus building energy performance simulation model used in the project. Validation was done in three stages: (i) plausibility testing, (ii) tuning of room temperature dynamics based on HVAC excitation experiments, (iii) comparison of longer-term net energy and room temperature statistics in different operation modes. The mean and variability of spatially averaged indoor temperatures were generally well reproduced. Simulated total heating and cooling net energy usage showed however in many cases deviations > 50%. They were traced plausibly (but not conclusively) to specific modeling and input assumptions. Validation results depended strongly on incorporation of controller feedback in the simulations. The used validation strategy helped to improve the model and advanced the understanding of the building.
Li Concentration Dependence of Dielectric Responses of Quantum Relaxor K<sub>1-x</sub>Li<sub>x</sub>TaO<sub>3</sub> (2007)

Single crystals of K1-xLixTaO3 (KLT) with different Li concentrations are grown by the self-flux method. Li concentrations in the crystals are determined by second-harmonic-generation microscope observations. Complex dielectric constants of KLT are measured in the temperature range from 20 K to room temperature and the frequency range from 5 Hz to 1 MHz. The results are analyzed using the Cole–Cole plot and the Vogel–Fulcher law. For x>4.4%, two semicircles of the Cole–Cole plot appear in a specific temperature region. These two relaxation processes can be explained by the different types of dynamics of Li dipole moments. The activation energy Ea and the characteristic frequency ν0 are determined from the fitting of the two models. It is found that Ea does not show strong Li concentration dependence. The origin of the phenomenon is discussed using a polar nanoregion picture.
Crystallisation control of drop-cast quasi-2D/3D perovskite layers for efficient solar cells (2020)

Abstract Introducing layered quasi-2D perovskite phases into a conventional 3D perovskite light-absorbing matrix is a promising strategy for overcoming the limited environmental stability of 3D perovskite solar cells. Here, we present a simple drop-casting method for preparing hybrid perovskite films comprising both quasi-2D and quasi-3D phases, formed using phenylethylammonium or iso-butylammonium as spacer cations. The film morphology, phase purity, and crystal orientation of the hybrid quasi-2D/3D perovskite films are improved significantly by applying a simple N 2 blow-drying step, together with inclusion of methylammonium chloride as an additive. An enhanced power conversion efficiency of 16.0% is achieved using an iso-butylammonium-based quasi-2D/3D perovskite layer which, to our knowledge, is the highest recorded to date for a quasi-2D/3D perovskite solar cells containing a non-spin-cast perovskite layer prepared under ambient laboratory conditions.
Risk factor analysis for pneumococcal meningitis in adults with invasive pneumococcal infection (2010)

Pneumococcal meningitis is a subgroup of invasive pneumococcal disease with a case-fatality rate of up to 30% and long-term sequelae in more than 50% of cases in adults in developed countries. We aimed to determine risk factors for this particular form of pneumococcal disease. We conducted a prospective population-based laboratory study of invasive pneumococcal disease in adults in North-Rhine-Westphalia, Germany from February 2001 to August 2006. All isolates underwent serotyping and susceptibility testing at the National Reference Centre for Streptococci in Aachen, Germany. Data were analysed using multiple linear regression. A total of 1043 isolates from bacteraemia and 131 isolates from meningitis were included into the study. Serotype 23F and being female were independent risk factors for pneumococcal meningitis. Being 60 years and serotype 1 were associated with a reduced odds ratio. Season, penicillin and macrolide resistance were not statistically associated with CNS involvement.
New evaluation of critical strain for internal crack formation in continuous casting (1992)

In order to determine the critical conditions for internal crack formation, tensile tests of cylindrical ingots with liquid core have been carried out. It was found that internal cracking occurred in the solid-fraction range between 0.99 and 0.80 corresponding to zero ductility temperature (ZDT) and zero strength temperature (ZST) respectively, only when strain given in this range exceeded critical value (1.6 %). This critical value was not influenced by strain rate and manner of deformation. At a lower strain rate, successive strain which exceeded the critical value between ZDT and ZST made the cracks longer with solidification progress. New evaluation of strain for internal crack formation in a continuous casting strand was found out.
Investigation and characterization of the enhanced humoral response following immunization with the lethal and edema toxins of Bacillus anthracis. (2007)

Charles Rodenberry and Ramjay Vatsan -for all their insights and suggestions.Special thanks go to CDR Joe Morris, who taught me everything I needed to know about protein purification and endotoxin.Special thanks also go to Dr. Stan Goldman, who has been invaluable in challenging me and providing focus to my usually scattered ideas