gebhart/patrepeval huggingface dataset:
Molecular cloning of serogroup- and serotype-specific genome segments from bluetongue virus serotype 11 (1989)

Genome segments 2, 6, 8, and 9 of bluetongue virus (BTV) serotype 11, coding for P2, NS1, NS2, and P6, respectively, were cloned into pUC 8. Sizes of segment-2 and segment-6 clones indicated partial copies (55% and 80% of full length, respectively), whereas segment 8 and 9 clones represented full-length copies. Northern blot hybridizations of the clones to the 5 United States BTV prototypic serotypes (2, 10, 11, 13, and 17) revealed segment-2 clone to be serotype-specific to BTV-11, whereas segment 6, 8, and 9 clones were able to detect all serotypes to varying degrees. All clones failed to detect the related orbivirus, epizootic hemorrhagic disease virus.
Modeling Tolerance Development for the Effect on Heart Rate of the Selective S1P<sub>1</sub>Receptor Modulator Ponesimod (2017)

Ponesimod is a selective sphingosine-1-phosphate-1 (S1P<sub>1</sub> ) receptor modulator currently under investigation for the treatment of multiple sclerosis. S1P receptor modulators reduce heart rate following treatment initiation. This effect disappears with repeated dosing, enabling development of innovative uptitration regimens to optimize patient safety. There are currently no published pharmacokinetic/pharmacodynamic models describing the heart rate reduction of S1P receptor modulators in humans. The model developed here provides quantification of this effect for ponesimod. A direct-effect I<sub>max</sub> model with estimated maximum reduction of 45%, tolerance development, and circadian variation best described this effect. The pooled data from nine clinical studies enabled characterization of interindividual variability. The model was used to simulate different treatment regimens to compare the effect of high initial doses vs. gradual uptitration with respect to the occurrence of bradycardia. The results indicate a better safety profile when using gradual uptitration. The model allows studying dosing regimens not clinically tested in silico.
Pyruvate kinase: studies on affinity labeling and active-site structure using the rabbit muscle enzyme. (1985)

Important advances have been made in recent years in the study of the structure of pyruvate kinase: the amino acid sequence of the enzymes from chicken muscle and yeast have been established and the three-dimensional structure of the cat muscle enzyme has been determined at 0.26 nm resolution. Work in our laboratory has shown that dialdehyde-ADP (oADP) can be used as an affinity label of rabbit muscle pyruvate kinase: if the enzyme is incubated with cold oADP in the presence of high ADP concentrations, dialyzed and then incubated with 14C-oADP, the enzyme inactivates and one mole of radioactive oADP incorporates per mole of enzyme subunit. A labeled peptide with a molecular weight of about 5900 has been purified from a tryptic digest of the modified enzyme. The first 26 residues of the peptide have been sequenced and this sequence is identical to a region in the chicken muscle enzyme and a peptide isolated from the bovine muscle enzyme specifically labeled with trinitrobenzenesulfonate. High homology is also found with a region of the yeast enzyme. All this suggests that the isolated peptide is part of the active site; the modified amino acid, probably a lysine, seems to be located in one of the alfa helices of domain A of the enzyme, according to the x-ray data.
Color Vision in Parkinsonʼs Disease (1995)

In recent studies, disorders of chromatic and achromatic vision in parkinsonian patients have been demonstrated; these could be partially restored after application of L-Dopa. In this study, the effect of a 3-day infusion therapy with amantadine sulphate on color vision was evaluated in 19 parkinsonian patients by use of the Farnsworth-Munsell 100-Hue test. Under this treatment, the motor symptoms of parkinsonism improved significantly as assessed by the part "motor examination" of the Unified Parkinson's Disease Rating Scale (UPDRS). However, the total error scores of the Farnsworth-Munsell 100-Hue test before and after amantadine sulphate infusions were unchanged [before therapy, 94.53 (SD = 52.09); after therapy, 99.5 (SD = 58.81)]. From these results, it can be concluded that the pathophysiology of dopaminergic pathways in the visual system differs from that of the basal ganglia.
CLINICOPATHOLOGICAL STUDY OF EARLY GASTRIC CARCINOMAS; THE EGGECADY OF MASS SCREENING (1993)

From 1975 to 1991, 450 patients with early gastric cancer were operated on in our hospital. Three hundred and seven patients were diagnosed by mass screening (mass screening (MS) group) and 143 visited medical institutes for abdominal symptoms (outpatient (OP) group). We compared clinicopathological features between the MS and OP groups. Both groups were similar in the age distribution, male-female ratio, locations of gastric lesions and macroscopic types. Microscopically, lesions in the MS group were less infiltrative in depth, width, lymphatic and venous permeation and lymph node metastasis than those of the OP group. Therefore, mass screening contributes to identifing earlier phases of gastric cancer, permitting limited surgery and thereby preserving quality of life.
A complete basis set model chemistry. IV. An improved atomic pair natural orbital method (1994)

An improved complete basis set-quadratic configuration interaction/atomic pair natural orbital (CBS-QCI/APNO) model is described in this paper. It provides chemical energy differences (i.e., D0 I.P., and E.A.) with a mean absolute error of 0.53 kcal/mol for the 64 first-row examples from the G2 test set, and is computationally feasible for species with up to three first-row atoms. A set of 20 CBS-QCI/APNO bond dissociation energies of hydrocarbons also agree with known experimental values to within less than 1 kcal/mol. Calculations on the cyclopropenyl radical and cyclopropenylidene provide new dissociation energies which are in accord with an interpretation of the thermochemistry emphasizing ring strain and aromaticity.
Bulk and particle properties of pine needle fuel beds – influence on combustion (2014)

This paper presents a study to assess the influence of pine needle layer characteristics on combustion for three pine species of the Mediterranean region of France. It identifies the key parameters that explain the combustion of this fuel bed component. A relationship between permeability of the litter layer, fuel bed porosity and needle geometrical properties is presented. Although permeability was found to influence the rate of heat release from the combustion of litter independent of litter species, this was not the case for litter layers with similar mass and porosity. This study also stresses the important role of particle properties on their time to piloted ignition. The surface-to-volume ratio (SVR) of the species is the essential parameter driving the time to ignition as it defines the thermal thickness of single needles. This parameter also influences the combustion dynamics of litters under forced convection. In that case, the heat release rate of pine needle litters with the same permeability increases with the SVR of the species.
A Customized Self-Assembling Peptide Hydrogel for Dental Pulp Tissue Engineering (2011)

Root canal therapy is common practice in dentistry. During this procedure, the inflamed or necrotic dental pulp is removed and replaced with a synthetic material. However, recent research provides evidence that engineering of dental pulp and dentin is possible by using biologically driven approaches. As tissue engineering strategies hold the promise to soon supersede conventional root canal treatment, there is a need for customized scaffolds for stem cell delivery or recruitment. We hypothesize that the incorporation of dental pulp-derived stem cells with bioactive factors into such a scaffold can promote cell proliferation, differentiation, and angiogenesis. In this study, we used a cell adhesive, enzyme-cleavable hydrogel made from self-assembling peptide nanofibers to encapsulate dental pulp stem cells. The growth factors (GFs) fibroblast growth factor basic, transforming growth factor β1, and vascular endothelial growth factor were incorporated into the hydrogel via heparin binding. Release profiles were established, and the influence of GFs on cell morphology and proliferation was assessed to confirm their bioactivity after binding and subsequent release. Cell morphology and spreading in three-dimensional cultures were visualized by using cell tracker and histologic stains. Subcutaneous transplantation of the hydrogel within dentin cylinders into immunocompromised mice led to the formation of a vascularized soft connective tissue similar to dental pulp. These data support the use of this novel biomaterial as a highly promising candidate for future treatment concepts in regenerative endodontics.
■ REVIEW : Chaos Theory and Epilepsy (1996)

Recently, interest has turned to the mathematical concept of chaos as an explanation for a variety of complex processes in nature. Chaotic systems, among other characteristics, can produce what appears to be random output. Another property of chaotic systems is that they may exhibit abrupt intermittent transitions between highly ordered and disordered states. Because of this property, it is hypothesized that epilepsy may be an example of chaos. In this review, some of the basic concepts of nonlinear dynamics and chaos are illustrated. Mathematical techniques developed to study the properties of nonlinear dynamical systems are outlined. Finally, the results of applying these techniques to the study of human epilepsy are discussed. The application of these powerful and novel mathematical techniques to analysis of the electroencephalogram has provided new insights into the epileptogenic process and may have considerable utility in the diagnosis and treatment of epilepsy. The Neuroscientist 2:118-126, 1996
Obinutuzumab (GA101) 1,000 mg versus 2,000 mg in patients with chronic lymphocytic leukemia (CLL): Results of the phase II GAGE (GAO4768g) trial. (2014)

7083 Background: Early phase 1/2 trials with GA101 in CLL demonstrated single-agent activity with suggestion of a dose response. GAGE (NCT01414205) is a multicenter, randomized study that evaluated GA101 at 2 doses in patients (pts) with symptomatic, untreated CLL. Methods: Randomization of 80 pts with intact organ function and ECOG PS <3 were stratified based on Rai stage (1–2 vs 3–4) and tumor mass (single lesion by CT scan, <5 cm vs ≥5 cm): GA101 1,000 mg (100 mg IV d1, 900 mg d2, 1000 mg d8, d15 of cycle 1; 1000 mg d1 of cycles 2–8) or 2000 mg (100 mg IV d1, 900 mg d2, 1,000 mg d3, 2,000 mg d8, d15 of cycle 1; 2,000 mg d1 of cycles 2–8). Each cycle was 21 days. ORR was assessed at 2 months post-therapy according to the International Workshop on CLL (iwCLL) criteria. Pts had similar pre-treatment demographics in the 2 arms. Median age was 67 (34–91) years, 36% women, 41% Rai stage 3-4, 29% with tumor masses ≥5 cm, 54% unmutated IGHV, and 10% del(17p13). Median follow-up was 11 months. Results: Key efficacy and safety results are shown in table below. Most frequent adverse event (AE) was infusion-related reactions (IRRs). No Grade (Gr) 3/4 IRRs occurred after cycle 1. A death (myocardial infarction) occurred after cycle 5, judged by site investigator as unrelated to GA101. Conclusions: These results demonstrated single-agent efficacy of GA101 at 1,000- and 2,000-mg doses, with a difference in ORR between the 2 arms (P = .08). No new safety signals were observed. Incidences of Gr 3/4 AEs were similar in each arm, except for IRRs. Further study is warranted to determine durability of response and long-term side effects of GA101. Clinical trial information: NCT01414205. Total N = 80 1,000 mg (n = 41) 2,000 mg (n = 39) ORRa, n (%) 20 (49) 26 (67) P value .08b CR/CRi, n (%) 2 (5) 8 (21) SD, n (%) 11 (27) 9 (23) PD, n (%) 3 (7) 0 (0) Unable to evaluate/missingc, n (%) 7 (17) 4 (10) Gr 3-4 AE, % IRR Neutropenia Infections 23 33 3 11 34 5 aORR based on investigator-reported end-of-treatment response, which includes CT scan performed 51+ days from last GA101 dose bPvalue is 2-sided, based on stratified Cochran-Mantel-Haenszel test on ORR cPts classified as missing if no post-baseline response assessments were available or all post-baseline response assessment were performed <51 days from last GA101 dose.
Deoxyribonucleotide Phosphatase from Rat Liver and Cultured Mouse Fibroblasts (1971)

An enzyme which catalyzes the preferential dephosphorylation of the 5′‐phosphates of deoxythymidine, deoxyuridine and deoxyguanosine was purified 100‐fold from rat liver. The preparation appeared to be free from contaminating phosphatase activities. The dephosphorylation of deoxyribonucleotides was dependent on the presence of Mg 2+ ions and had a pH optimum around 6.0. The K m value for the dephosphorylation of deoxythymidine 5′‐phosphate was 5.7 mM. High activities of the enzyme were found in cultured mouse fibroblasts. In parasynchronously growing cells no changes of enzyme activity were found during the cell cycle.
High incidence of recurrent in stent thrombosis after successful treatment of a first in stent thrombosis (2008)

Recurrent IST is a frequent and early event after successful treatment of a first IST. Our results suggest that mechanical factors like residual dissection and residual diameter stenosis should be carefully tracked down. In addition, patients with multiple recurrent IST and the early time course of recurrent IST also suggest a potential role of inadequate antiplatelet therapy.
Fast ignition relevant study of the flux of high intensity laser-generated electrons via a hollow cone into a laser-imploded plasma (2008)

An integrated experiment relevant to fast ignition . A Cu-doped deuterated polymer spherical shell target with an inserted hollow Au cone is imploded by a six-beam 900-J, 1-ns laser. A 10-ps, 70-J laser pulse is focused into the cone at the time of peak compression. The flux of high-energy electrons through the imploded material is determined from the yield of CuKα fluorescence by comparison with a Monte Carlo model. The electrons are estimated to carry about 15% of the laser energy. Collisional and Ohmic heating are modeled, and Ohmic effects are shown to be relatively unimportant. An electron spectrometer shows significantly greater reduction of the transmitted electron flux than is calculated in the model. Enhanced scattering by instability-induced magnetic fields is suggested. An extension of this fluor-based technique to measurement of coupling efficiency to the ignition hot spot in future larger-scale fast ignition experiments is outlined.
Acute Toxicity and Mutagenicity Study on Branched Corn Syrup and Evaluation of Its Laxative Effect in Humans. (2001)

We developed a branched corn syrup (BCS, average molecular weight: 500, content of indigestible portion: 45%) by heat treatment of indigestible dextrin with hydrochloric acid. To confirm the safety of BCS, we conducted both an acute toxicity test and a mutagenicity test. Moreover, we observed gastroenteric effects of BCS in fifty healthy humans. The results are summarized as follows. 1) There was no death observed after oral administration of BCS in Sprague-Dawley-strain rats. Lethal dose (LD)50, value was estimated to be more than 10 g/kg body weight. 2) No mutagenicity was observed in Salmonella typhimurium TA98, TA100, TA1535, TA1537, or Escherichia coli WP2uvrA. 3) Fifty adults were divided into five groups often (five of each sex) and orally administered BCS at 0.2, 0.3, 0.4. 0.5 and 0.6 g/kg body weight as indigestible portion. Although no diarrhea was observed in females, BCS at 0.6 g/kg as indigestible portion caused diarrhea in two out of five males. The maximum non-effective dose of indigestible portion of BCS was estimated to be 0.5 g/kg in males and more than 0.6 g/kg in females.
LARP Long Nb3Sn Quadrupole Design (2008)

A major milestone for the LHC Accelerator Research Program (LARP) is the test, by the end of 2009, of two 4m-long quadrupole magnets (LQ) wound with Nb3Sn conductor. The goal of these magnets is to be a proof of principle that Nb3Sn is a viable technology for a possible LHC luminosity upgrade. The design of the LQ is based on the design of the LARP Technological Quadrupoles, presently under development at FNAL and LBNL, with 90-mm aperture and gradient higher than 200 T/m. The design of the first LQ model will be completed by the end of 2007 with the selection of a mechanical design. In this paper we present the coil design addressing some fabrication technology issues, the quench protection study, and three designs of the support structure.
NSRG-05. SAFETY OF ULTRASOUND-INDUCED BLOOD-BRAIN BARRIER OPENING IN PEDIATRIC PATIENTS WITH REFRACTORY SUS-TENTORIAL MALIGNANT BRAIN TUMORS BEFORE CHEMOTHERAPY ADMINISTRATION – THE SONOKID CLINICAL TRIAL (2018)

To determine the safety of repeated disruption of the blood-brain barrier (BBB) by low intensity pulsed ultrasound (LIPU) with the Sonocloud® device in children with recurrent malignant supra-tentorial brain tumors prior to intra-venous carboplatin chemotherapy. The safety of this procedure is currently being validated in adult patients with recurrent glioblastoma (Carpentier et al. 2016). MATERIAL AND This single-center phase I/IIa clinical trial will include 12 to 24 patients aged 5 to 18 years, with recurrent malignant supra-tentorial brain tumors. The Sonocloud® device will be implanted into the skull under general anesthesia, during a standard procedure (biopsy or resection). Thanks to a transdermic connexion, sonications will be performed monthly in combination with injection of an ultrasound contrast agent (Sonovue®). US parameters will be based on the adult patients study. BBB disruption will be evaluated using multimodal magnetic resonance imaging (MRI). Carboplatin will be injected during the hour following the sonication. Patients will receive a maximum of 6 monthly sonications and will be followed at least for 6 months after the last sonication. EXPECTED The principal criteria will be the absence of grade ≥ 3 neurological toxicity (NCI-CTCAE 4.0 Version, clinical and radiological assessment) linked to the US-induced opening of the BBB after first treatment. Secondary evaluation criterias will include tolerance of repeated sonications, overall survival and progression-free survival, and feasibility of the technique. SONOKID is the first clinical trial assessing the feasibility and tolerance of US-induced opening of the BBB in children. SPONSOR Canceropole Ile de France.
Synthesis and base hydrolysis of pentaammine N,N-dimethylformamide and acetonitrile complexes of rhodium(III) and iridium(III) (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and base hydrolysis of pentaammine N,N-dimethylformamide and acetonitrile complexes of rhodium(III) and iridium(III)Neville J. Curtis and Alan M. SargesonCite this: J. Am. Chem. Soc. 1984, 106, 3, 625–630Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February 1984https://pubs.acs.org/doi/10.1021/ja00315a029https://doi.org/10.1021/ja00315a029research-articleACS PublicationsRequest reuse permissionsArticle Views274Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Reallocation Problems in Scheduling (2013)

In traditional on-line problems, such as scheduling, requests arrive over time, demanding available resources. As each request arrives, some resources may have to be irrevocably committed to servicing that request. In many situations, however, it may be possible or even necessary to reallocate previously allocated resources in order to satisfy a new request. This reallocation has a cost. This paper shows how to service the requests while minimizing the reallocation cost. We focus on the classic problem of scheduling jobs on a multiprocessor system. Each unit-size job has a time window in which it can be executed. Jobs are dynamically added and removed from the system. We provide an algorithm that maintains a valid schedule, as long as a sufficiently feasible schedule exists. The algorithm reschedules only a total number of O(min{log^* n, log^* Delta}) jobs for each job that is inserted or deleted from the system, where n is the number of active jobs and Delta is the size of the largest window.
ChemInform Abstract: 1‐METHYLPHENANTHRO(3,4‐B)THIOPHENE: DETERMINATION OF THE TERTIARY STRUCTURE IN SOLUTION AND IN THE CRYSTALLINE STATE BY NMR SPECTROSCOPY AND X‐RA DIFFRACTION (1985)

Abstract Die Kondensation zwischen dem Phosphonsäureester (I) und dem Thiophenaldehyd(II) liefert das Olefin (III), das bei der Bestrahlung in Gegenwart von Iod zu der im Titel genannten Verbindung (IV) cyclisiert wird.
Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma (2000)

Aberrant or increased expression of cyclooxygenase (COX)-2 has been implicated in the pathogenesis of many diseases including carcinogenesis. COX-2 has been shown to be over-expressed in some human cancers. Employing semi-quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry we assessed COX-2 expression in samples of pair-matched benign and cancer tissue obtained from the same prostate cancer patient. Mean levels of COX-2 mRNA were 3.4-fold higher in prostate cancer tissue (n = 12) compared with the paired benign tissue. The immunoblot analysis demonstrated that as compared to benign tissue COX-2 protein was over-expressed in 10 of 12 samples examined. Immunohistochemical analysis also verified COX-2 over-expression in cancer than in benign tissue. To our knowledge, this is the first in vivo study showing an over-expression of COX-2 in prostate cancer. These data suggest that COX-2 inhibitors may be useful for prevention or therapy of prostate cancer in humans.
Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961). (2004)

Asparagine, Gln and five other AA declined during ASNase treatment. Asparagine and Gln % deamination values are highly correlated with serum ASNase activity. Asparaginase may indirectly cause moderate depletion of serum Arg and Ser levels, providing an enhancement in leukemia blasts apoptosis. Toxicity from the ASNase and other drugs could enhance the decrease of AA serum levels. Further studies are needed to verify these findings and their potential clinical importance in the treatment of ALL patients.