gebhart/patrepeval huggingface dataset:
The high incidence of vascular thromboembolic events (VTE) in advanced urothelial cancer (UC) patients (pts) treated with carboplatin (Cb): Analysis of treatment with gemcitabine (G)/cb (GCb), gcb/bevacizumab (GCbBev), or gemcitabine/cisplatin (GCis). (2014)

316 Background: VTE occur in ~13% of pts receiving Cis-based therapy for UC. Cb-based therapy is considered less thrombogenic but no definitive data exist to support this conclusion. While Bev added to chemotherapy (Ch) increases VTE in other tumors, VTE impact when added to UC Ch is unknown. This study evaluated the incidence of and etiologic factors for VTE in UC pts treated with GCb, GCbBev and GCis. Methods: UC pts treated from 6/2006 to 6/2010 on a GCbBev protocol were analyzed prospectively. Planned therapy was 6 cycles of GCbBev then Bev alone; pts who had ≥ 3 cycles were included. Similar UC pts treated with GCb or GCis during the same time were retrospectively evaluated. Type of VTE and potential contributing clinical factors were collected. VTE was defined as pulmonary embolism, vascular thrombosis, myocardial infarction or cerebral vascular accident. Associations with Ch regimen were tested using Fisher’s exact test or linear regression. Factors associated with VTE were analyzed using conditional logistic regression stratified by Ch regimen. Results: 198 pts were analyzed. VTE occurred in 13/51 (26%) GCbBev pts, 22/92 (24%) GCb pts, and 8/55 (15%) GCis pts. Age (≤65 vs >65; p<0.001), having had a prior cystectomy (p<0.001), mass near pelvic vessels (p=0.027), Khorana risk group (p=0.025) and anti-platelet therapy (p=0.036) were significantly associated with the Ch regimen reflecting cohort-specific differences. Type of Ch was not associated with any VTE (p=0.3) or type of VTE (arterial vs venous) (p=0.11). Having had a prior cystectomy was associated with increased risk of VTE (OR 2.2, 95% CI 1.0-5.0, p=0.047). Conclusions: This is the largest series reporting VTE in Cb-treated UC pts; the VTE rate of 24% (95% CI 17, 32%) is higher than expected. Bev does not appear to increase this risk. VTE in Cis-treated pts (15%) was similar to prior reports. The finding that pts with advanced UC are at high risk of VTE regardless of the specific platinum agent warrants further study of Cb therapy-related risk and analysis for contributing factors including prior pelvic surgery.
An endo-β-1,4-glucanase gene (<i>celA</i>) from the rumen anaerobe <i>Ruminococcus albus</i> 8: cloning, sequencing, and transcriptional analysis (1996)

A genomic library of Ruminococcus albus 8 DNA was constructed in Escherichia coli using bacteriophage lambda ZapII. This library was screened for cellulase components and several Ostazin brilliant red/carboxymethyl cellulose positive clones were isolated. All of these clones contained a common 3.4-kb insert, which was recovered as a plasmid by helper phage excision. The carboxymethyl cellulase coding region was localized to a 1.4-kb region of DNA by nested deletions, and a clone containing the entire celA gene was sequenced. Analysis of the sequence revealed a 1231-bp open reading frame, coding for a protein of 411 amino acids with a predicted molecular weight of 45 747. This protein, designated CelA, showed extensive homology with family 5 endoglucanases by both primary amino acid sequence alignment and hydrophobic cluster analysis. Cell-free extracts of E. coli containing the celA clone demonstrated activity against carboxymethyl cellulose and acid swollen cellulose but not against any of the p-nitrophenol glycosides tested, indicating an endo-beta-1,4-glucanase type of activity. In vitro transcription-translation experiments showed that three proteins of 48,000, 44,000, and 23,000 molecular weight were produced by clones containing the celA gene. Northern analysis of RNA extracted from R. albus 8 grown on cellulose indicated a celA transcript of approximately 2700 bases, whereas when R. albus 8 was grown on cellobiose, celA transcripts of approximately 3000 and 600 bases were detected. Primer extension analysis of these RNAs revealed different transcription initiation sites for the celA gene when cells were grown with cellulose or cellobiose as the carbon source. These two sites differed by 370 bases in distance. A model, based on transcription and sequence data, is proposed for celA regulation.
The Molecular Genetic Basis of Polymorphism in Normal Color Vision (1992)

People with normal color vision don't all have the same complement of cone pigments. Individual differences in the spectral sensitivities of cone pigments have been studied extensively through the examination of color matches (e.g. Neitz and Jacobs, 1986, 1990; He and Shevell, 1990; Webster and MacLeod, 1988). However, the exact nature of the cone pigment differences among color normals, and their cause, is still poorly understood.
713. The reactions of phosphorothiolates with halogens (1957)

C. J. M. Stirling, J. Chem. Soc., 1957, 3597 DOI: 10.1039/JR9570003597
A SiGe HBT limiting amplifier for fast switching of mm-wave super-regenerative oscillators (2017)

For super-regenerative oscillators (SRO), a principal component that determines several aspects of the system response is the quench signal generation. The high oscillation frequency of mm-wave SROs enables fast quench rates that could well exceed 10 GHz. This is desirable because higher symbol rates and, consequently, higher communication data rates could be achieved. This work presents a limiting amplifier fabricated in a 0.13-μm SiGe BiCMOS technology (fT = 300 GHz) for the generation of fast switching signals from an external RF sinusoidal source. The amplifier core is based on a modified differential Cherry-Hooper topology with embedded emitter followers, which is preceded by an active balun input stage. An additional tapered emitter follower output stage is implemented to drive 50-Ω loads. The amplifier delivers 27.3 dB of differential gain over a 25-GHz bandwidth with a total power consumption of 79 mW. The power consumption is only 42 mW when excluding the output 50-Ω driver that is only necessary for measurement. The circuit occupies an active area of only 100 μm × 150 μm due to its compact inductor-less design. It generates a high-speed differential output from a single input with a maximum peak-to-peak output voltage swing of 1.2 V and a rise/fall time of 5.6/6.0 ps at 20 GHz.
Influence of Powder Geometry on Powder Injection Molding Process Parameters (2003)

Powder injection molding (PIM) is an alternative route to produce components from metallic powder that have been growing in last 10 years. The process may be divided in five basic steps, that is powder-binder mixing, mixture injection, binder extraction and sinterization. The greatest advantage of the metallic powder processing is that it surmounts difficulties from conventional powder metallurgy regarding feasibility of tridimensional shapes and density homogeneity. Powder selected to PIM process must provide a high powder packing and sinterability, which is necessary to obtain adequate final density levels. In this way, spherical powders not higher than 20 pm are usually used. In the present work, the possibility of using non-spherical powders for PIM was investigated. To provide basis for comparisons, spherical and non-spherical powders were tested. Powder influence was analyzed concerning viscosity behavior.
A new type of information retrieval system (1976)

In the period 1964-1968, Peter G. Ossorio [10,11,12] developed and tested, on a pilot study basis, a new approach to the problem of automatic document retrieval. Ossorio's studies were entirely successful, as pilot studies, and show the feasibility of using his approach to produce a new kind of retrieval system.These retrieval systems do not operate by word matching. The basic approach is to simulate the judgement of competent human judges of the conceptual content of each document, and the request. This judgement is then used to retrieve those documents with conceptual content most similar to that of the request.Each document is processed only at the time it is added to the data base, in time linear in the number of words in the document that the system recognizes. The retrieval request is in ordinary English. Time for retrieval is linear in the number of documents on file. Documents are retrieved in order of similarity of conceptual content to that of the request. The system works, in certain respects, better on full text documents, providing better descriptions of document content, and more detailed cross-indexing.The new type of system shows a number of interesting features. Among these are:(1) Much better performance than systems using the old techniques;(2) Faithful representation of the judgement of the person(s) whose judgement is being simulated, thus providing the possibility of individualized retrieval systems;(3) Ability to explain to a user why it retrieved certain documents, and not others. With this information, the user can alter his request, or instruct the system to judge things differently;(4) Automatic recognition of requests the system cannot properly handle;(5) Sub-documentary indexing reflecting heterogeneity of material. As is often the case with a new paradigm, Ossorio's work raises at least as many questions as it answers. This paper presents the new approach, and the results of some first explorations in the new field.
Probing at implants with peri‐implantitis and its relation to clinical peri‐implant bone loss (2012)

The results of this study yielded differences in the pocket probing measurements at implants with or without the prosthetic reconstruction in place and that the probing pocket depth following the removal of the prosthesis had a high correlation with the amount of bone loss at implants assessed during surgery.
Polymer concretes improved by fiber reinforcement and gamma irradiation (2009)

Abstract The well-known key problem with concrete is that its compressive strength and the compression modulus are insufficient for a variety of applications. Our polymer concrete (PC) consists of an unsaturated polyester resin as the polymeric matrix, silica sand as the inorganic aggregate, plus atactic polypropylene (PP) fibers. A further property improvement can be achieved by gamma irradiation and we apply here two methods. The first method consists in irradiation of PP fibers first and then adding them to the PC. The second route consists in irradiation of PC after inclusion of PP fibers. Along both routes we have applied the radiation at dosages ranging from 5 to 150 kGy. In the second route irradiation of silica sand results in larger contact areas of surfaces with PP fibers and with the polyester resin-as seen in scanning electron microscopy. The second route provides compressive properties which is better by a factor of two or three (depending on the irradiation dose) than the first one.
PN code acquisition for the spread-spectrum optical on-off-keying communication system (1990)

A model for spread-spectrum (SS) communication using a direct-detection optical on-off-keying (OOK) channel is proposed and investigated. In this model, the intensity of the transmitted optical field is modulated by a pseudonoise (PN) code and random binary data symbols. Two PN code acquisition models, namely the maximum-likelihood (ML) and the single dwell-time (SDT) models, are proposed. The performances of the ML and the SDT models are obtained in terms of the probability of missed acquisition, the probability of false alarm, and the probability of missed detection under the Gaussian approximation. The mean acquisition times are obtained and used to provide a comparison between the proposed ML and SDT models.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification of novel androgen receptor target genes in prostate cancer (2007)

AR genomic occupancy is similar between LNCaP and C4-2B cells and is not biased towards 5' gene flanking sequences. The AR transcriptionally regulates less than half the genes nearby AR-occupied regions, usually but not always, in a ligand-dependent manner. Most are stimulated and a few are repressed. In general, response is stronger in C4-2B compared to LNCaP cells. Some of the genes near AR-occupied regions appear to be regulated by the AR in vivo as evidenced by their expression levels in prostate cancer tumors of various stages. Several AR target genes discovered in the present study, for example PRKCD and PYCR1, may open avenues in PCa research and aid the development of new approaches for disease management.
Theoretical and Experimental Studies on Gadolinium at Ultra High Pressure. (1998)

The high-pressure structural phase transformations in gadolinium (Gd) were studied by energy-dispersive x-ray diffraction up to 118 GPa at room temperature using a synchrotron source. Gadolinium undergoes five transitions: h. c. p→Smtype→double-h. c. p→f. c. c→distorted f. c. c→b. c. m (body-centered monoclinic), with increasing pressures. The last transition to b. c. m occurs at 59±2 GPa, accompanied by a volume collapse of about 5%. We suggest that this low-symmetry structure and volume collapse in gadolinium is analogous to the well-known electronic transition in cerium metal related to loss of magnetic moment and eventual delocalization of f-shell under pressure.
Effects of the neuronal phosphoprotein synapsin I on actin polymerization. II. Analytical interpretation of kinetic curves. (1992)

The general features of the kinetics of actin polymerization are investigated by mathematical models, with the aim of identifying the kinetically relevant parameters in the process and detecting and interpreting the alterations occurring in actin polymerization under various experimental conditions. Polymerization curves, obtained by following the increase in fluorescence of actin derivatized with N-(1-pyrenyl) iodoacetamide, are fitted using analytical equations derived from biochemical models of the actin polymerization process. Particular attention is given to the evaluation of the effects of the neuronal phosphoprotein synapsin I. The models obtained under various ionic conditions reveal that synapsin I interacts with actin in a very complex fashion, sharing some of the properties of classical nucleating proteins but displaying also actions not described previously for other actin-binding proteins. Synapsin I appears to bind G-actin with a very high stoichiometry (1:2-4), and the complex behaves as an F-actin nucleus, producing actin filaments under conditions where spontaneous polymerization is negligible. These actions of synapsin I are markedly affected by site-specific phosphorylation of the protein. An original transformation of the fluorescence data, which estimates the disappearance rate of actin monomer toward the critical concentration, is presented and shown to be of general usefulness for the study of actin-binding proteins.
Bicyclic Lactams as Chiral Homoenolate Equivalents:  Synthesis of (−)-Penienone (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTBicyclic Lactams as Chiral Homoenolate Equivalents: Synthesis of (−)-PenienoneAlex G. Waterson and A. I. MeyersView Author Information Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523 [email protected].Cite this: J. Org. Chem. 2000, 65, 21, 7240–7243Publication Date (Web):September 27, 2000Publication History Received5 June 2000Published online27 September 2000Published inissue 1 October 2000https://pubs.acs.org/doi/10.1021/jo000860yhttps://doi.org/10.1021/jo000860ybrief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views523Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Aldehydes,Amides,Mixtures,Molecular structure Get e-Alerts
An FPGA Software Defined Radio Platform with a High-Level Synthesis Design Flow (2013)

Software defined radio (SDR) opens a new door to future Internet of Things with higher degree of designing flexibility in context of wireless system development. Prototyping a remote implementation of wireless protocols on a hardware over the web requires a highly versatile software radio platform along with laid-back designing tools. To this aim, an FPGA-based SDR scheme has been proposed combining Virtex-6 Perseus 6010 platform capabilities and a design flow based on High-Level Synthesis (HLS) tools. A full IEEE 802.15.4 (ZigBee) physical layer has been implemented on the proposed platform from a C-language dataflow specification. All the results have been analyzed to lead to a fair comparison between different design flows. Although the proposed SDR has some designing issues, it shows a noticeable designing potentiality to flexible prototyping of future wireless systems.
Ras Induces a General DNA Demethylation Activity in Mouse Embryonal P19 Cells (1995)

We demonstrate that expression of v-Ha-ras in mouse embryonal P19 cells results in genome-wide demethylation. Analysis of the pattern of methylation of specific genes reveals that different types of genes are demethylated in the ras transfectants: skeletal muscle specific genes, a gene specifically expressed in the adrenal cortex (c21), ubiquitous genes, and exogenously introduced sequences. Transient transfection and in vitro demethylation assays reveal that the ras transfectants express high levels of a general DNA demethylation activity. This demonstrates that the general DNA demethylation activity in mouse embryonal cells is controlled by an important cellular signal transducer and that DNA demethylase is a potential downstream effector of Ras.
Genome‐scale models of metabolism and gene expression extend and refine growth phenotype prediction (2013)

Growth is a fundamental process of life. Growth requirements are well-characterized experimentally for many microbes; however, we lack a unified model for cellular growth. Such a model must be predictive of events at the molecular scale and capable of explaining the high-level behavior of the cell as a whole. Here, we construct an ME-Model for Escherichia coli--a genome-scale model that seamlessly integrates metabolic and gene product expression pathways. The model computes ~80% of the functional proteome (by mass), which is used by the cell to support growth under a given condition. Metabolism and gene expression are interdependent processes that affect and constrain each other. We formalize these constraints and apply the principle of growth optimization to enable the accurate prediction of multi-scale phenotypes, ranging from coarse-grained (growth rate, nutrient uptake, by-product secretion) to fine-grained (metabolic fluxes, gene expression levels). Our results unify many existing principles developed to describe bacterial growth.
Chromium-carbene-mediated synthesis of 4-oxo .beta.-lactams (malonimides) and malonic acid derivatives (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromium-carbene-mediated synthesis of 4-oxo .beta.-lactams (malonimides) and malonic acid derivativesBenito Alcaide, Gema Dominguez, Joaquin Plumet, and Miguel A. SierraCite this: J. Org. Chem. 1992, 57, 2, 447–451Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00028a013https://doi.org/10.1021/jo00028a013research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An improved attosecond pulse characterization based on the FROG-CRAB technique (2014)

The FROG-CRAB method was improved to account for the photoionization process, significantly improving its accuracy for low-photon-energy EUV pulses. A method for accounting for the photoionization step while using the conventional retrieval algorithm was demonstrated.
Age‐related changes in the three‐dimensional morphological structure of human facial skin (1997)

Although sunlight is important in the development of three-dimensional changes in surface morphology (wrinkles) in the face, other factors seem to play important roles for the progression of these changes.
Identification of the Genes Involved in Riemerella anatipestifer Biofilm Formation by Random Transposon Mutagenesis (2012)

Riemerella anatipestifer causes epizootics of infectious disease in poultry that result in serious economic losses to the duck industry. Our previous studies have shown that some strains of R. anatipestifer can form a biofilm, and this may explain the intriguing persistence of R. anatipestifer on duck farms post infection. In this study we used strain CH3, a strong producer of biofilm, to construct a library of random Tn4351 transposon mutants in order to investigate the genetic basis of biofilm formation by R. anatipestifer on abiotic surfaces. A total of 2,520 mutants were obtained and 39 of them showed a reduction in biofilm formation of 47%-98% using crystal violet staining. Genetic characterization of the mutants led to the identification of 33 genes. Of these, 29 genes are associated with information storage and processing, as well as basic cellular processes and metabolism; the function of the other four genes is currently unknown. In addition, a mutant strain BF19, in which biofilm formation was reduced by 98% following insertion of the Tn4351 transposon at the dihydrodipicolinate synthase (dhdps) gene, was complemented with a shuttle plasmid pCP-dhdps. The complemented mutant strain was restored to give 92.6% of the biofilm formation of the wild-type strain CH3, which indicates that the dhdp gene is associated with biofilm formation. It is inferred that such complementation applies also to other mutant strains. Furthermore, some biological characteristics of biofilm-defective mutants were investigated, indicating that the genes deleted in the mutant strains function in the biofilm formation of R. anatipestifer. Deletion of either gene will stall the biofilm formation at a specific stage thus preventing further biofilm development. In addition, the tested biofilm-defective mutants had different adherence capacity to Vero cells. This study will help us to understand the molecular mechanisms of biofilm development by R. anatipestifer and to study the pathogenesis of R. anatipestifer further.