gebhart/patrepeval huggingface dataset:
Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms (2019)

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a broad range of human disorders. It is well recognized clinically in the context of superficial thrombophlebitis (thrombosis and inflammation of superficial veins); however, it is more dangerous when it develops in the microvasculature of injured tissues and organs. Microvascular thrombosis with associated inflammation is well recognized in the context of sepsis and ischemia-reperfusion injury; however, it also occurs in organ transplant rejection, major trauma, severe burns, the antiphospholipid syndrome, preeclampsia, sickle cell disease, and biomaterial-induced thromboinflammation. Central to thromboinflammation is the loss of the normal antithrombotic and anti-inflammatory functions of endothelial cells, leading to dysregulation of coagulation, complement, platelet activation, and leukocyte recruitment in the microvasculature. α-Thrombin plays a critical role in coordinating thrombotic and inflammatory responses and has long been considered an attractive therapeutic target to reduce thromboinflammatory complications. This review focuses on the role of basic aspects of coagulation and α-thrombin in promoting thromboinflammatory responses and discusses insights gained from clinical trials on the effects of various inhibitors of coagulation on thromboinflammatory disorders. Studies in sepsis patients have been particularly informative because, despite using anticoagulant approaches with different pharmacological profiles, which act at distinct points in the coagulation cascade, bleeding complications continue to undermine clinical benefit. Future advances may require the development of therapeutics with primary anti-inflammatory and cytoprotective properties, which have less impact on hemostasis. This may be possible with the growing recognition that components of blood coagulation and platelets have prothrombotic and proinflammatory functions independent of their hemostatic effects.
El mundo se divide entre ladrones y policías (1993)

El trabajo de investigacion articulado con el quehacer profesional en el Trabajo Social es la guia de estas reflexiones en las que la historia y opinion de los jovenes con los que hemos desarrollado esas tareas deviene testimonio y fuente permanente de cuestionamiento. 
Traslucir esa interaccion tiene por objetivo compartir los interrogantes que suscita esta situacion social que, en virtud de los estigmas que provoca, no admite neutralidad ni asepsia.
Best‐answer selection criteria in a social Q&A site from the user‐oriented relevance perspective (2007)

Abstract As an attempt to better understand how people seek, share, and evaluate information in a social Q&A environment, this study identifies the selection criteria people employ when they select best answers in Yahoo! Answers in the context of relevance research. Using content analysis, we analyzed the comments people left upon the selection of best answers to their own questions. From 1,200 samples of comments, only 465 mentioned the specific reasons for their selection, thus becoming eligible for analysis. Through an iterative process of evaluating the types of comments, the best‐answer selection criteria were inductively derived and grouped into seven value categories: Content value, Cognitive value, Socio‐emotional value, Information source value, Extrinsic value, Utility, and General statement. While many of the identified criteria overlap with those found in previous relevance studies, the Socio‐emotional value was particularly prominent in this study, especially when people ask for opinions and suggestions. These findings reflect the characteristics of a social Q&A site and extend our understanding of the relevance of an electronic environment where people bring their every day problem‐solving and decision‐making tasks.
Drug therapy of urinary urge incontinence: a systematic review (2002)

Published trials support anticholinergic drugs as efficacious therapy for urinary urge incontinence, with predictable side effects. At present, these agents represent the pharmacological treatment of choice for this condition. The potential value of selected alternative drugs is underscored by the available data.
Topical 8‐methoxypsoralen increases the efficacy of narrowband ultraviolet B in psoriasis (2009)

Topical 8-MOP gel plus narrowband UVB has greater efficacy than narrowband UVB alone in psoriasis.
Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats (1997)

Proinflammatory cytokines play an important role in the pathogenesis of anemia in inflammatory diseases. Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) have been reported to inhibit the synthesis of erythropoietin (EPO) in vitro. To evaluate the in vivo significance of this observation, we have investigated effects of the administration of bacterial lipopolysaccharide (LPS) and IL-1 beta on renal EPO production in rats. Measurements by competitive reverse-transcription polymerase chain reaction showed that EPO mRNA levels were significantly reduced in the kidneys of normoxic rats 6 h after the injection of LPS (0.1 or 1 mg/kg). In addition, LPS and IL-1 beta (1 microgram/kg) inhibited the increase in EPO mRNA and plasma EPO levels when administered to rats before hypoxia exposure (8% O2 in the inspiratory gas). Evidence for an inflammatory reaction in the kidneys of LPS-treated rats was provided by measurements of greatly elevated renal TNF-alpha mRNA levels. Furthermore, kidneys isolated from LPS-created rats produced less immunoreactive EPO when perfused hypoxically in vitro for 2 h. Thus mediators of the immune response inhibit renal EPO gene expression in vivo, which is relevant with respect to the impaired synthesis of EPO in inflammatory diseases in humans.
Item Selection in Computerized Classification Testing (2008)

Several alternatives for item selection algorithms based on item response theory in computerized classification testing (CCT) have been suggested, with no conclusive evidence on the substantial superiority of a single method. It is argued that the lack of sizable effect is because some of the methods actually assess items very similarly through different calculations and will usually select the same item. Consideration of methods that assess information across a wider range is often unnecessary under realistic conditions, although it might be advantageous to utilize them only early in a test. In addition, the efficiency of item selection approaches depend on the termination criteria that are used, which is demonstrated through didactic example and Monte Carlo simulation. Item selection at the cut score, which seems conceptually appropriate for CCT, is not always the most efficient option. A broad framework for item selection in CCT is presented that incorporates these points.
The Case of the Irish Republic’s Funds (1927)

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Face aging with conditional generative adversarial networks (2017)

It has been recently shown that Generative Adversarial Networks (GANs) can produce synthetic images of exceptional visual fidelity. In this work, we propose the first GAN-based method for automatic face aging. Contrary to previous works employing GANs for altering of facial attributes, we make a particular emphasize on preserving the original person's identity in the aged version of his/her face. To this end, we introduce a novel approach for “Identity-Preserving” optimization of GAN's latent vectors. The objective evaluation of the resulting aged and rejuvenated face images by the state-of-the-art face recognition and age estimation solutions demonstrate the high potential of the proposed method.
Dupilumab in the Treatment of Dyshidrosis: A Report of Two Cases. (2018)

Dupilumab (Dupixent, Regeneron Pharmaceuticals and Sanofi Genzyme) is a novel biologic medication recently approved by the FDA for the treatment of moderate-to-severe atopic dermatitis in adults who have not achieved adequate control with topical medications. Dyshidrotic eczema is a distinct entity, often considered on the spectrum of atopic dermatitis, that primarily effects the palms and soles; it is often associated with considerable morbidity yet is frequently challenging to treat. We report two cases of recalcitrant dyshidrotic eczema treated successfully with dupilumab at standard dosing. Further studies to establish the efficacy of dupilumab in the treatment of dyshidrosis are warranted. <em>J Drugs Dermatol. 2018;17(3):355-356.</em> .
Job Design (2015)

Abstract Job design concerns the content and organization of tasks and activities into jobs and roles, and includes individual‐ and group‐level characteristics such as autonomy, variety, significance, and demands. The way that jobs are designed can have a significant impact on employee job attitudes and behaviors. Early theories relevant to job enrichment and autonomous work groups have been expanded to keep pace with wider social and technological developments that have affected the nature of work. For example, more attention is now being given to social and relational aspects of work, as well as how employees influence and craft their own job designs.
Interaction Between Two Burning Vertical Walls (1989)

A study was conducted on the structure of the turbulent reacting flow developed between two burning vertical walls. Large-scale, gas-supplied, watercooled, sintered-metal burners facing each other were used for the experiments. We examined the influence of different parameters such as channel width, burner, length, gas supplied, flow rate and mass transfer driving force B , on the establishment of a steady turbulent fire. The flow field (velocity and turbulence) was characterized through a statistical analysis of LDV measurements. Mean and fluctuating temperature profiles were also obtained with a similar analysis. The results indicate that, as the distance between both walls decreases, radiation is no longer the dominant mode of heat transfer. The character of the flow changes from natural to forced convection, and there is a "relaminarization" of the flow.
Synthesis and Antiplatelet Activities of N-Arylmethyl-3,4-dimethylpyrano(2,3-c)pyrazol-6-one Derivatives. (1992)

A series of new 1- and 2-arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives were synthesized and examined for their antiplatelet activities. Some of these compounds showed significant inhibitory activities. Among them, 1-phenylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6(1H)-one (4a), 2-(2'-methoxyphenyl)methyl-3,4-dimethylpyrano[2,3-c]pyrazol-6(2H)- one (3e) and 2-(3'-methoxyphenyl)methyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-(2H) - one (3f) were the most effective. These inhibitors acted in a concentration-dependent manner. The antiplatelet effect of compound 3f is due to the inhibition of thromboxane A2 formation and the blockade of thromboxane A2/prostaglandin endoperoxide receptor in washed rabbit platelets.
Glass-fibre-reinforced Epoxy Composites using Epoxidized Cardanol as Diluent (1991)

Glass-fibre-reinforced epoxy composites were prepared and evaluatedfor their mechanical chemical and electrical properties. The effect of incorporating epoxidized cardanol as diluent on such properties of the composites based on the diglycidyl ether of bisphenol-A was investigated The tensile strength andflexural strength increased significantly. The composites prepared using epoxy fortifiers showed a good improvement in properties such as tensile strength, flexural strength and interlaminar shear strength.
Flattening and/or expanding of pH gradients in isoelectric focusing gels exemplified with PhastSystem (1988)

A simple method of flattening and/or expanding of pH gradients in isoelectric focusing is described for any pH interval desired: to modify pH gradients near one electrode a paper strip soaked with carrier ampholytes is applied onto the gel close to the opposite electrode. In order to flatten central parts of pH intervals paper strips are applied onto the gel at both electrodes. Conditions and criteria (e.g. amount and pH intervals of carrier ampholytes, width and localization of the paper strip, separation period) for optimization are presented with PhastSystem using ready-made gels with three different pH intervals and pI marker proteins (Pharmacia). Examples utilizing erythrocyte lysates are presented.
Genetically Engineered Mice by Pronuclear DNA Microinjection (2012)

The generation of transgenic mice by DNA microinjection is a powerful tool to investigate the molecular regulation of gene expression, development, and disease. The power of this technology is that foreign DNA can be introduced into every cell of a developing organism and the phenotypic impact of this genetic modification can be investigated in a system under the constraints of normal development and physiology. The generation of transgenic mice requires the preparation of the transgene DNA construction, collection of one-cell fertilized mouse embryos, injection of the transgene into mouse embryos, and transfer of the surviving embryos. Mice born from such manipulations are then screened for the presence of the transgene. The execution of these procedures requires a highly efficient system otherwise the cost of the generation of these mice can be cost prohibitive. However, the production of these animals can serve as an invaluable research resource.
Structure modeling of machine tools and internet-based implementation (2005)

Reconfigurability of machine tools is one of the critical factors to realize the responsive manufacturing systems to satisfy the mass-customization production. This paper presents the methods to model and simulate the machine tools on Internet in response to change in the machining requirements. Specifically, a set of module combination rules and a modeling method of the structure of machine tools using connectivity graph are developed. In response to the user requirements, kinematic relations and structures of machine tools can be derived using the module combination rules and connectivity graph relationships. Internet-based simulator of machine tools is implemented and presented. The developed machine tool simulator can be used to verify the structure of machine tools derived from the user requirements.
Theta and Gamma Power Increases and Alpha/Beta Power Decreases with Memory Load in an Attractor Network Model (2011)

Changes in oscillatory brain activity are strongly correlated with performance in cognitive tasks and modulations in specific frequency bands are associated with working memory tasks. Mesoscale network models allow the study of oscillations as an emergent feature of neuronal activity. Here we extend a previously developed attractor network model, shown to faithfully reproduce single-cell activity during retention and memory recall, with synaptic augmentation. This enables the network to function as a multi-item working memory by cyclic reactivation of up to six items. The reactivation happens at theta frequency, consistently with recent experimental findings, with increasing theta power for each additional item loaded in the network's memory. Furthermore, each memory reactivation is associated with gamma oscillations. Thus, single-cell spike trains as well as gamma oscillations in local groups are nested in the theta cycle. The network also exhibits an idling rhythm in the alpha/beta band associated with a noncoding global attractor. Put together, the resulting effect is increasing theta and gamma power and decreasing alpha/beta power with growing working memory load, rendering the network mechanisms involved a plausible explanation for this often reported behavior.
Server Resource Dimensioning and Routing of Service Function Chain in NFV Network Architectures (2016)

The Network Function Virtualization (NFV) technology aims at virtualizing the network service with the execution of the single service components in Virtual Machines activated on Commercial-off-the-shelf (COTS) servers. Any service is represented by the Service Function Chain (SFC) that is a set of VNFs to be executed according to a given order. The running of VNFs needs the instantiation of VNF instances (VNFI) that in general are software components executed on Virtual Machines. In this paper we cope with the routing and resource dimensioning problem in NFV architectures. We formulate the optimization problem and due to its NP-hard complexity, heuristics are proposed for both cases of offline and online traffic demand. We show how the heuristics works correctly by guaranteeing a uniform occupancy of the server processing capacity and the network link bandwidth. A consolidation algorithm for the power consumption minimization is also proposed. The application of the consolidation algorithm allows for a high power consumption saving that however is to be paid with an increase in SFC blocking probability.
Reduction of dislocations in GaN epilayers grown on Si(111) substrate using SixNy inserting layer (2004)

High-quality GaN films have been grown on Si(111) substrate by metalorganic chemical vapor deposition using a SixNy inserting layer. Due to the large difference of lattice constant and thermal expansion coefficient between GaN and Si,GaN growth on Si(111) substrate usually leads to an initially high dislocation density and cracks. It is found that the SixNy inserting layer plays a very important role in the enhancement of crystal quality and surface morphology of GaN films. The crystalline quality of overlying GaN layer grown on SixNy inserting layer depends on the deposition time of SixNy inserting layer. The high-resolution x-ray diffraction results show that the dislocation density in GaN epilayer decreases with increasing SixNy growth time. It was confirmed that the misfit dislocations in the GaN films with 5min deposition time for SixNy inserting layer almost stop at the SixNy inserting layer by transmission electron microscope measurements.
Effects of Interruptions on the Computerised Clerical Task Performance (1996)

Abstract. This paper presents results of an exploratory experimental study of the effects of interruptions on the execution of computerised clerical tasks, provides classification of interruption handling strategies, and gives some recommendations for the user interface design for frequently interrupted work conditions.
Alternative splicing of smooth muscle myosin heavy chains and its functional consequences (1996)

The aim of our study was to determine the relation between alternatively spliced myosin heavy chain (MHC) isoforms and the contractility of smooth muscle. The relative amount of MHC with an alternatively spliced insert in the 5′ (amino terminal) domain was determined on the protein level using a peptide-directed antibody (a25K/50K) raised against the inserted sequence (QGPSFAY). Smooth muscle MHC isoforms of both bladder and myometrium but not nonmuscle MHC reacted with a25/50K. Using a quantitative Western-blot approach the amount of 5′-inserted MHC in rat bladder was detected to be about eightfold higher than in normal rat myometrium. The amount of heavy chain with insert was found to be decreased by about 50% in the myometrium of pregnant rats. Although bladder contained significantly more 5′-inserted MHC than myometrium, apparent maximal shortening velocities (Vmax) were comparable, being 0.138 ± 0.012 and 0.114 ± 0.023 muscle length per second of skinned bladder and normal myometrium fibers, respectively. Phosphorylation of myosin light chain 20 induced by maximal Ca2+/calmodulin activation was the same in bladder and myometrial fibers. These results suggest that the amount of 5′-inserted MHC is not necessarily associated with contractile properties of smooth muscle. © 1996 Wiley-Liss, Inc.
Onset and Rime Awareness and Analogies in Reading (1992)

It has been known for a long time that there is a strong relationship between a child's phonological awareness and that child's progress in reading (Bryant & Bradley, 1985; Calfee, Lindamood, & Lindamood, 1973; Cossu, Shankweiler, Liberman, Tola, & Katz, 1987; Liberman, Shankweiler, Fischer, & Carter, 1974; Lundberg, Frost, & Petersen, 1988; Maclean, Bryant, & Bradley, 1987; Rosner & Simon, 1971; Tunmer & Nesdale, 1985). It is also known that measures of rhyming and alliteration are especially strong predictors of later reading progress, as they still account for a significant proportion of the variance after other variables are partialed out of the equation (e.g., Bradley & Bryant, 1983; Bryant, Bradley, Maclean, & Crossland, 1989; Ellis & Large, 1987, Lundberg, Olofsson & Wall, 1980). For example, Bryant et al. (1989) showed that nursery rhyme knowledge at 3 years was related to reading ability at 6 years even after differences in social background and IQ were taken into account. Recently, Goswami & Bryant (1990) suggested that the linguistic units onset and rime may be crucial in explaining this robust link between rhyming and reading. Specifically, a child's ability to categorise words by onset-rime units (the onset of the word beak corresponds with the initial consonant, b-; the rime corresponds with the vowels and final consonant, -eak) may be related to that child's awareness of spelling sequences in words (Goswami, 1990; Goswami & Bryant, in press), and this may facilitate the development of reading. This hypothesis is based on the finding that children can make analogies between spelling patterns in words to help them to read new words. For example, children can use the spelling-sound pattern of a word like beak to make an inference about the sound of new
Saying “welcome” is not enough: women, information systems and equity in work (2000)

The rise of all forms of information systems has been one of the major factors affecting the nature of work over the last decade. This article reports on research that suggests that whilst females may now gain more experience of computers and information systems at an earlier age, this does not appear to lead to more favourable evaluations of jobs involving computers. If women overcome initial negative perceptions of jobs involving computers then the particular style, manner, skills or approach that are seen as prerequisite for success, can constitute an additional barrier over and above that of the “glass ceiling”. The study looked at factors influencing initial attitudes towards computers, female attitudes to jobs involving computers and factors influencing self‐selection into gender‐typical and atypical jobs, including IT‐based jobs. The article considers the actions required from managers in many roles, including those with responsibility for staff development, marketing and recruitment.