gebhart/patrepeval huggingface dataset:
Fatty Acid Lessens Halothane??s Inhibition of Energy Metabolism in Isolated Hepatocytes (1990)

This study has examined whether adverse halothane effects on liver-cell energy metabolism are influenced by the availability of alternate substrates for energy-generating reactions. Halogenated volatile anesthetics affect both energy supply and energy demand in tissues, and cellular energy deficits have been implicated in anesthetic hepatotoxicity. Using hepatocytes isolated from fed rats either pretreated with phenobarbital or not treated (+PB or -PB cells, respectively), we studied the cellular energetic effects of providing fatty acid (oleic acid) along with glucose as substrate(s) for energy metabolism, while exposing the cells to 0%-2% halothane. In -PB cells incubated with glucose alone, there were halothane dose-related decreases in the oxygen (O2) consumption rate (VO2) and in the balance between adenosine triphosphate (ATP) supply and demand (ATP/ADP ratio), but no effect on lactate metabolism (lactate consumption or production) over the 10-min incubation period. Adding oleate along with glucose (a) raised VO2 but lowered ATP/ADP in the absence of halothane; (b) eliminated the decreases in VO2 and ATP/ADP seen when halothane was introduced; and (c) increased lactate consumption in both the presence and absence of halothane. In +PB cells, VO2 was higher, ATP/ADP lower, and lactate consumption also lower than in -PB cells under comparable conditions. Halothane or oleate effects, or both, on energy metabolism were thus qualitatively similar in +PB and -PB cells, except that in +PB cells incubated without oleate, lactate formation developed as halothane was increased from 0% to 2%, reflecting activation of glycolysis due to insufficient mitochondrial ATP production.(ABSTRACT TRUNCATED AT 250 WORDS)
Evaluating 3D pointing techniques (2013)

LIBRARIES to lend or sell copies of this dissertation in paper, microform or electronic formats, and b) LIBRARY AND ARCHIVES CANADA to reproduce, lend, distribute, or sell copies of this thesis anywhere in the world in microform, paper or electronic formats and to authorise or procure the reproduction, loan, distribution or sale of copies of this thesis anywhere in the world in microform, paper or electronic formats. The author reserves other publication rights, and neither the dissertation nor extensive extracts from it may be printed or otherwise reproduced without the author’s written permission.
Heat shock and other stress response systems of plants. (1989)

In the course of evolution, plants have acquired a whole set of distinct but partially overlapping stress response systems helping them to survive and propagate under a multitude of unfavourable environmental conditions. The book deals mainly with the molecular and cell biological aspects of stress response. A concise description of heat shock is followed by a discussion of similarities and differences with regard to other stress response systems. These include oxidation, heavy metals, anaerobiosis, low temperature, water deficiency, starvation, wounding, pathogen infections and genomic stress. In all cases, phenomena of induced stress tolerance are observed. The analysis of stress-induced genes frequently leads to multigene families also integrated into developmental programs.
A Controlled Trial on Utility of Oral Zinc Supplementation in Acute Dehydrating Diarrhea in Infants (1988)

A controlled, randomized trial was conducted in 50 infants with acute dehydrating diarrhea to evaluate the effect of oral zinc supplementation in acute diarrhea. After completion of rehydration, 25 infants in Group A received oral zinc sulfate (20 mg elemental zinc twice daily) and an equal number in Group B were given placebo (glucose). Both groups were comparable with respect to various initial characteristics including nutritional status, diarrheal disease, serum alkaline phosphatase, and serum and rectal mucosal zinc content. During therapy all the assessed parameters of zinc status (serum alkaline phosphatase and serum and rectal zinc) recorded significant elevation and reduction in Groups A and B, respectively. At recovery the zinc status of Group A was significantly better and was nearer that of healthy controls. The diarrheal duration and frequency in the zinc-supplemented group were lower, but the differences were not significant (0.05 less than p less than 0.1). However, when only subjects with relatively severe initial zinc depletion (rectal zinc lower than the 15th percentile of healthy controls; 11 in Group A and 14 in Group B) were considered, the diarrheal duration and frequency were significantly (p less than 0.05 and p less than 0.01, respectively) lower in the zinc-supplemented cases. Weight gain in both groups was similar. It is concluded that oral zinc administration in acute diarrhea can replenish body zinc status and this may shorten the diarrheal duration and frequency in children with relatively severe zinc depletion.
International Liaison Committee on Resuscitation.: 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. (2005)

DI-fusion, le Dépôt institutionnel numérique de l'ULB, est l'outil de référencementde la production scientifique de l'ULB.L'interface de recherche DI-fusion permet de consulter les publications des chercheurs de l'ULB et les thèses qui y ont été défendues.
3 차원 초음파로 진단한 선천성 자궁 기형 (1999)

목적: 3차원 초음파를 사용하여 초기 임신 상태에서 선천성 자궁 기형의 진단을 평가하기 위하여. 방법: 1998년 8월부터 1998년 12월 까지 선천성 자궁 기형의 의심이 가는 초기 산모 10명을 대상으로 복부 및 질식 소식자를 사용하여 3차원 초음파[메디슨, 한국]를 시행하였다. 결과: 3차원 초음파를 사용한 10예 전부에서 자궁강과 자궁 근층의 저부를 확인하였으며, 5예에서 정상 자궁을 가진 초기 임신을 확인 하였고, 2예의 궁상 자궁, 1예의 중격 자궁, 1예의 쌍각 자궁, 그리고 1예의 중복 자궁을 진단하였다. 결론: 3차원 입체 초음파는 자궁 강의 모양과 자궁 저부 함요의 정도를 정확하게 파악할수 있어 선천성 자궁 기형의 진단 및 감별에 유용한 진단 방법이다.
Pottery from Shechem Excavated 1913 and 1914 (1969)

In a
The Existence of the K+ Channel in Plant Mitochondria (1999)

In this study, evidence is given that a number of isolated coupled plant mitochondria (from durum wheat, bread wheat, spelt, rye, barley, potato, and spinach) can take up externally added K(+) ions. This was observed by following mitochondrial swelling in isotonic KCl solutions and was confirmed by a novel method in which the membrane potential decrease due to externally added K(+) is measured fluorimetrically by using safranine. A detailed investigation of K(+) uptake by durum wheat mitochondria shows hyperbolic dependence on the ion concentration and specificity. K(+) uptake electrogenicity and the non-competitive inhibition due to either ATP or NADH are also shown. In the whole, the experimental findings reported in this paper demonstrate the existence of the mitochondrial K(+)(ATP) channel in plants (PmitoK(ATP)). Interestingly, Mg(2+) and glyburide, which can inhibit mammalian K(+) channel, have no effect on PmitoK(ATP). In the presence of the superoxide anion producing system (xanthine plus xanthine oxidase), PmitoK(ATP) activation was found. Moreover, an inverse relationship was found between channel activity and mitochondrial superoxide anion formation, as measured via epinephrine photometric assay. These findings strongly suggest that mitochondrial K(+) uptake could be involved in plant defense mechanism against oxidative stress due to reactive oxygen species generation.
Peri- and intratumoral T and B lymphocytic infiltration in breast cancer. (2008)

Peritumoral and intratumoral infiltrates of T and B lymphocytes are different and depend on tumor size.
Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H (2007)

Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (CFH) with atypical haemolytic uraemic syndrome (aHUS), age-related macular degeneration (AMD) and membranoproliferative glomerulonephritis (MPGN). This review summarizes our current knowledge of CFH genetics and examines the CFH genotype-phenotype correlations that are helping to understand the molecular basis underlying these renal and ocular pathologies.
Managing Distributed, Shared L2 Caches through OS-Level Page Allocation (2006)

This paper presents and studies a distributed L2 cache management approach through OS-level page allocation for future many-core processors. L2 cache management is a crucial multicore processor design aspect to overcome non-uniform cache access latency for good program performance and to reduce on-chip network traffic and related power consumption. Unlike previously studied hardware-based private and shared cache designs implementing a "fixed" caching policy, the proposed OS-micro architecture approach is flexible; it can easily implement a wide spectrum of L2 caching policies without complex hardware support. Furthermore, our approach can provide differentiated execution environment to running programs by dynamically controlling data placement and cache sharing degrees. We discuss key design issues of the proposed approach and present preliminary experimental results showing the promise of our approach
Testicular anti-Müllerian hormone: history, genetics, regulation and clinical applications. (2006)

Anti-Müllerian hormone (AMH), also called MUllerian inhibiting substance (MIS) is a product of supporting gonadal Sertoli and granulosa cells. Its main physiological role is the induction of regression of Müllerian ducts in male fetuses but it also plays a role in Leydig cell steroidogenesis and in follicular development. It is a member of the transforming growth factor B family and signals through two serine/threonine kinase receptors, only one of whom, type II, is specific. Type I receptors and the intracytoplasmic signaling molecules are shared with the bone morphogenetic family. AMH is positively regulated by SF1, SOX9 and FSH. Testosterone is a powerful downregulator. Males lacking functional AMH or AMH receptor genes do not undergo regression of MUllerian derivatives during fetal life. AMH is an excellent marker of prepubertal testicular function and has gained recognition as a valuable marker of follicular reserve in adult women.
DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis (2019)

Sequencing technologies have changed not only our approaches to classical genetics, but also the field of epigenetics. Specific methods allow scientists to identify novel genome-wide epigenetic patterns of DNA methylation down to single-nucleotide resolution. DNA methylation is the most researched epigenetic mark involved in various processes in the human cell, including gene regulation and development of diseases, such as cancer. Increasing numbers of DNA methylation sequencing datasets from human genome are produced using various platforms-from methylated DNA precipitation to the whole genome bisulfite sequencing. Many of those datasets are fully accessible for repeated analyses. Sequencing experiments have become routine in laboratories around the world, while analysis of outcoming data is still a challenge among the majority of scientists, since in many cases it requires advanced computational skills. Even though various tools are being created and published, guidelines for their selection are often not clear, especially to non-bioinformaticians with limited experience in computational analyses. Separate tools are often used for individual steps in the analysis, and these can be challenging to manage and integrate. However, in some instances, tools are combined into pipelines that are capable to complete all the essential steps to achieve the result. In the case of DNA methylation sequencing analysis, the goal of such pipeline is to map sequencing reads, calculate methylation levels, and distinguish differentially methylated positions and/or regions. The objective of this review is to describe basic principles and steps in the analysis of DNA methylation sequencing data that in particular have been used for mammalian genomes, and more importantly to present and discuss the most pronounced computational pipelines that can be used to analyze such data. We aim to provide a good starting point for scientists with limited experience in computational analyses of DNA methylation and hydroxymethylation data, and recommend a few tools that are powerful, but still easy enough to use for their own data analysis.
The normal exfoliative cytology of menstrual blood. (1979)

Illustration shows the ghostly figure of a manic-looking man, labeled "Judge Lynch" and carrying a book labeled "Lynch Law" and a lighted torch, hovering over a procession of people. The procession is led by three solid citizens followed by farmers, unruly elements, and finally a long line of regular citizens including women, who look back at a small column of smoke in the distance - presumably a lynching. One of the unruly men shoots at a dog. "Judge Lynch" was the personification of the practice, frequently found in the South, of executing African Americans suspected of crimes without the benefit of trial. In the second decade of the Twentieth Century, Progressives advocated various reforms designed to circumvent the state governments viewed as the tools of entrenched interests. The Recall was intended to allow the citizenry to directly vote officials out of office. The cartoonist suggests that this first be used to abolish the practice of lynching. (Source: LCCN 2005676912 and LJR.)
Treatment of Keratoconjunctivitis Sicca with Lacrisert (1986)

A double-blind cross-over comparative study on the effect of Lacrisert versus oculoguttae viscosae and saline has been conducted. Lacrisert is a soluble solid tear substitute which is applied once-a-day. The object was to compare the safety and patient acceptability of Lacrisert and oculoguttae viscosae, and to compare the efficacy of Lacrisert to oculoguttae viscosae and saline. Twenty-nine patients suffering from primary Sjögren's syndrome (Copenhagen criteria), 2 male and 27 female, age: median 56 years, range 32-79 years. Lacrisert was applied once-a-day, and saccharose crystals of similar appearance was used as placebo. All patients were treated for 4 periods of 3 weeks: Lacrisert + saline versus placebo + saline and Lacrisert + oculoguttae viscosae versus placebo + oculoguttae viscosae. The patients were examined before entering the study and after each of the 4 periods using: slit-lamp, corneal sensitivity, BUT, Schirmer-1-test and Rose-bengal staining. Comparing Lacrisert to saline a significant improvement in BUT (p less than 0.01) and in Rose-bengal staining (p less than 0.01) was found, whereas other patients were unchanged. Comparing Lacrisert with oculoguttae viscosae no significant difference in clinical parameters could be detected. The patients complained of minor discomfort. Most prominent was a tendency to loose the Lacrisert due to an inadequate solubilisation of the rod caused by the lack of aqueous tears. We conclude that Lacrisert may help patients with primary Sjögren's syndrome provided that they have some secretory capacity left in the tear glands.
Diltiazem enhances the effects of triazolam by inhibiting its metabolism* (1996)

Diltiazem has a clinically significant interaction with oral triazolam. The data is highly suggestive that diltiazem inhibits the metabolism of triazolam during the first-pass and elimination phases. Prescription of triazolam should be avoided if a patient is using diltiazem or other potent inhibitors of CYP3A.
Television (1999)

inetecn hundred ninety-eight was N a milestone year for tlie tclevision broadcast, and production community as it began the transition to DTV.The Consumer Electronics show kicked off thc year with prototypc receivers being displayed by almost every nianufacturcr.Temporary broadcast facilitics were set up by ABC, CBS, and PBS to provide receivcr manufacturers with actual HDTV broadcast signals.Many observcrs indicated that they were disappointed that the manufacturing community had not progressed further in DTV receivcr development.However, the manufacturers assured their detractors they would have product available for the 1998 holiday scason.By February , the I n t c rn a t i o n a 1 Broadcast Center in Nagano, Japan, was i n full swing.Tlic 525-line section of the center had been designed as a complctc GO 1 componcnt digital system.The host broadcaster, NHK, took on the monuiiicntal task of broadcasting thc entire Nagano games i n HDTV.They employed well over 300 HD cameras in covering thc cvent and wcre able to overcome fiber and microwave conductivity hurdles that would have seemed Olympian the year before.CBS utilized 45 Mbit/sec 4:2:2 compression to backhaul tlic NTSC signal to the U.S. wherc it was decompressed to baseband audio and video for commercial integration.No sooner was the Olympics over than evcryone was focused on NAB 1998.One did not have to walk far i n the exhibit area to realize that HDTV had transitioned from thc wings to center stagc.Almost every manufacturer was displaying some form of HD-related equipmcnt.The I .5 Gbitlscc SMPTE 292 routers, that wcrc considered to be cost-prohibitive and technologically impractical, pro-Rohcd 1' .Scitlcl.
Environmental Protection and Sealing (2001)

Abstract Environmental effects of ground and flight environments, including temperature extremes, damage by chemical fluids, moisture, and so forth, affect the durability of polymer-matrix composites. This article provides information on corrosion control methods in aircraft structures. It discusses the design considerations for sealants in joints. The article describes the common methods to seal aircraft structures: fay surface, fillet, butt joint, channel, brush, and form-in-place seals. It discusses the surface preparation and application method of primer and topcoat systems. Primer and paint application equipment as well as sealant application equipment are reviewed.
Skin Genetically Engineered as a Bioreactor or a ‘Metabolic Sink’ (2002)

Genetically manipulated human keratinocytes can produce and secrete medically relevant proteins to the circulation. Genetically modified skin may also function as a 'metabolic sink' detoxifying the body of metabolites which accumulate in certain metabolic diseases. At the National Institutes of Health (NIH), Bethesda, Md., a clinical trial investigating the treatment of an ocular disease using the skin as a 'metabolic sink' for ornithine accumulating in gyrate atrophy patients is being prepared. The trial will involve the transplantation of a small patch of autologous keratinocytes, transduced ex vivo, onto the thighs of patients with gyrate atrophy. We are now investigating other diseases where this technology may be applicable such as in the treatment of hyperphenylalaninemia or hypercholesterolemia.
Telemedicine: history, applications, and impact on librarianship. (1996)

This paper traces the uses of telecommunications in health care from the Civil War era to the present. Topics include the National Aeronautics and Space Administration's involvement in the origins of current telemedicine systems and the impact of television. Applications of telemedicine discussed include remote consultation and diagnosis, specialty clinical care (including examples from anesthesia, dermatology, cardiology, psychiatry, radiology, critical care, and oncology), and others (including examples of patient education, home monitoring, and continuing education). The concluding section highlights how telemedicine affects health sciences librarianship, beginning with the development of online computerized literature searching. This section also discusses the medical resources available to health sciences librarians as a result of the Internet.
Surface-exposed protein antigens of the gonococcal outer membrane (1981)

Whole, 125I-labeled gonococci (GC) were incubated with rabbit sera against whole GC. After washing, the [125I]GC were lysed in detergent, and radioiodinated antigen-antibody complexes were immunoprecipitated by protein A-Sepharose. Several GC outer membrane proteins, including proteins I, II, and III, could be identified in immunoprecipitates obtained with these antisera. In many immunoprecipitates, a 44K protein was present. Reactivity of antisera toward protein II could be demonstrated, and some rabbit sera contained very prominent apparent antibody activity toward this protein. Proteins I and III were found in similar ratios in immunoprecipitates, suggesting that they form heteropolymers in GC outer membranes. Qualitative and quantitative difference in antibody reactivity and specificity could be demonstrated with serially obtained sera from rabbits immunized with whole GC. The use of viable or Formalin-fixed heat-killed staphylococci yielded "non-immunological" precipitation of 125I-labeled GC constituents; this occurred with staphylococci regardless of whether they contained protein A.
Business process management in the cloud with data and activity distribution (2012)

Business Process Management (BPM) gives organizations the ability to identify, monitor
and optimize their business processes. A Business Process Management System (BPMS) is
used to keep track of business process models and to coordinate the execution of business
processes.
Organizations that want to make use of BPM might have to deal with high upfront investments,
since not only software and hardware needs to be purchased, but also personnel
needs to be hired for installing and maintaining the systems. In addition, scalability can be
a concern for an organization. A BPMS can only coordinate a certain amount of business
process instances simultaneously. In order to serve all customers in peak-load situations,
additional machines are necessary. Especially when these machines are only rarely needed,
buying and maintaining the machines might become expensive.
Nowadays, many BPM vendors offer cloud-based BPM systems. The advantage of these
systems is that organizations can use BPM software in a pay-per-use manner. In addition,
the cloud solution should offer scalability to the user, so that in peak-load situations, additional
resources can be instantiated relatively easily. A major concern of cloud-based
solutions for organizations, is the fear of losing or exposing confidential data. Since the
cloud solution is hosted outside an organization and data is stored within the cloud, organizations
fear they might lose control over their data.
In this report we consider a BPM architecture in which parts of a business process are
placed in the cloud and parts are placed on-premise. A decomposition framework for
automatically decomposing a business process into collaborating business processes for
deployment in the cloud or on-premise is developed in this work. The decomposition is
driven by a list of markings in which the distribution location for each of the activities in
a business process is defined. In addition, data restrictions can be defined, to ensure that
sensitive data does not cross the organizational borders.
The solution we present is business process language independent. An intermediate model
is used for capturing the behavior of a business process and the decomposition is performed
on this intermediate model, rather than on an existing language. The decomposition
framework consists of a transformation chain of three transformations, used for
converting a business process, defined in an existing business process language into an instance
of the intermediate model, performing the decomposition algorithm on the instance
and transforming the result back into a business process defined in an existing business
process language.
We analyze possible transformation rules, explain the implementation of the transformations
and show an example of the decomposition framework by performing a case study.