gebhart/patrepeval huggingface dataset:
The Interfacial Transport of Phenothiazine-Bile Salt Ion Pairs (1980)

Journal Article The Interfacial Transport of Phenothiazine-Bile Salt Ion Pairs Get access M Ahmed, M Ahmed Department of Pharmacy, University of Nottingham Search for other works by this author on: Oxford Academic Google Scholar J S Burton, J S Burton Department of Pharmacy, Berk Pharmaceuticals Ltd., Surrey Search for other works by this author on: Oxford Academic Google Scholar J Hadgraft, J Hadgraft Department of Pharmacy, University of Nottingham Search for other works by this author on: Oxford Academic Google Scholar I W Kellaway I W Kellaway The Welsh School of Pharmacy, UWIST, Cardiff Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 32, Issue Supplement_1, December 1980, Page 66P, https://doi.org/10.1111/j.2042-7158.1980.tb10869.x Published: 12 April 2011
Control of place-cell activity in an open field (1989)

The nature of place-cell firing in the hippocampus is discussed with relevance to control of discharge characteristics in a “cue-sterile” open-field environment. Although it can be demonstrated that cell firing in this context is controlled by spatial influences, it is also shown that firing within the place field and the location of the place field can be altered by nonspatial influences as well. Within-field firing in this environment is controlled to a large degree by the trajectory of the animal’s movements. Analyses involving forward or backward time shifts in firing, adjusted for variation in speed of movement, trajectory convergence, and number of spikes, produced no indication that complex cell firing reflects either memory for, or anticipated arrival in, locations other than where the cell fired originally. Nor is the location of the place field strictly dependent upon the spatial features of the apparatus, since it is shown that place-cell firing can be changed readily by altering the significance or relevance of a particular location. Place-cell plasticity in this context suggests nonspatial control over where place cells fire. These results are considered in terms of hippocampal cell coding of specific types of spatial information. Considerable discussion is devoted to whether coding of place is shifted in the same cell, or whether there is emergence of place firing by a different cell (detected by the same electrode), as an explanation for this apparent plasticity. Although no resolution is provided, the implications of these findings for a strict spatial mapping theory of the hippocampus are addressed and other interpretations are explored.
Crystal Structure and Pair Potentials: A Molecular-Dynamics Study (1980)

With use of a Lagrangian which allows for the variation of the shape and size of the periodically repeating molecular-dynamics cell, it is shown that different pair potentials lead to different crystal structures.
Bringing Real Market Participants' Real Preferences into the Lab: An Experiment that Changed the Course Allocation Mechanism at Wharton (2016)

This paper reports on an experimental test of a new market design that is attractive in theory but makes the common and potentially unrealistic assumption that â€œagents report their typeâ€ ; that is, that market participants can perfectly report their preferences to the mechanism. Concerns about preference reporting led to a novel experimental design that brought real market participantsâ€™ real preferences into the lab, as opposed to endowing experimental subjects with artificial preferences as is typical in market design. The experiment found that market participants were able to report their preferences â€œaccurately enoughâ€ to realize efficiency and fairness benefits of the mechanism even while preference-reporting mistakes meaningfully harmed mechanism performance. [Working Paper 22448]
Power-conserving centralized organization ofad hoc wireless networks (1999)

This paper presents a physical layer-based framework for the organization of ad hoc wireless networks. The focus is quasi-static environments, such as multimedia classrooms, and situations characterized by real-time services and high traffic loads. In these cases, centralized control and a star-connected topology may be preferable due to its simplicity and high efficiency. Using a link loss matrix, an approach is developed for selection of a network leader that takes into consideration link losses and transmitter powers. Both minimax and minisum criteria are established, and a number of conditions are established for determining uplink, downlink, Bayesian and universal leaders. A QoS-based iterative algorithm for determination of link transmit powers is also proposed, a special case of which provides the link loss matrix for leader selection. The algorithm also provides the information required to determine a set of candidate leaders, whose members can assume leadership without interruption or degradation of network operation. Copyright © 1999 John Wiley & Sons, Ltd.
Miniature laser-pumped cesium cell atomic clock oscillator (2002)

Our approach to a low-power compact atomic oscillator is based on the use of a diode laser to excite a small cell (/spl sim/0.1 cm/sup 3/) containing cesium vapor and buffer gases. Laser wavelength and power are controlled solely with current and temperature, providing a compact, low-power, rugged, spectrally-pure, collimated optical source. A succession of physics packages, when operated with analog laboratory electronics, have typically given short term Allan deviation of /spl sigma/(/spl tau/)/spl tau//sup 1/2//spl les/2/spl times/10/sup -11/ for 10</spl tau/<200 s. The clock electronics uses a single microprocessor, with time division multiplexing of the numerous control loops. A physics package operated uninterrupted for 285 days with first generation digital electronics, gave short term /spl sigma/(/spl tau/)/spl tau//sup 1/2/=2.5/spl times/10/sup -10/, and /spl sigma/(/spl tau/)<3/spl times/10/sup -11/ for /spl tau/<1/spl times/10/sup 6/ s, without removal of drift. Current designs compatible with a power goal of 300 mW over a 0 to 50/spl deg/C temperature range, within a 25 cm/sup 3/ clock package are showing short term Allan deviation of /spl sigma/(/spl tau/)/spl tau//sup 1/2/<5/spl times/10/sup -11/.
Catalytic Microcapsules Assembled from Enzyme–Nanoparticle Conjugates at Oil–Water Interfaces (2009)

Involuntary association: Anionic beta-galactosidase enzymes associate with positively charged Au nanoparticles to produce reduced-charge conjugates, which assemble at oil-water interfaces to result in stable microcapsules (see picture). The microcapsules were formed quickly and showed high enzymatic activity, which makes them promising materials for biotechnology applications.
Oral<i>N</i>‐acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats (2003)

Oxidative stress is involved in the pathogenesis of pulmonary fibrosis, therefore antioxidants may be of therapeutic value. Clinical work indicates that N-acetylcysteine (NAC) may be beneficial in this disease. The activity of this antioxidant was examined on bleomycin-induced lung damage, mucus secretory cells hyperplasia and mucin Muc5ac gene expression in rats. NAC (3 mmol x kg(-1) x day(-1)) or saline was given orally to Sprague-Dawley rats for 1 week prior to a single intratracheal instillation of bleomycin (2.5 U x kg(-1)) and for 14 days postinstillation. NAC decreased collagen deposition in bleomycin-exposed rats (hydroxyproline content was 4,257+/-323 and 3,200+/-192 microg x lung(-1) in vehicle- and NAC-treated rats, respectively) and lessened the fibrotic area assessed by morphometric analysis. The bleomycin-induced increases in lung tumour necrosis factor-alpha and myeloperoxidase activity were reduced by NAC treatment. The numbers of mucus secretory cells in airway epithelium, and the Muc5ac messenger ribonucleic acid and protein expression, were markedly augmented in rats exposed to bleomycin. These changes were significantly reduced in NAC-treated rats. These results indicate that bleomycin increases the number of airway secretory cells and their mucin production, and that oral N-acetylcysteine improved pulmonary lesions and reduced the mucus hypersecretion in the bleomycin rat model.
The effect of age and gender on the relative fatigability of the human adductor pollicis muscle (2000)

The purpose of this study was to examine the relative influence of such factors as age, gender, and absolute force on the fatiguability of the human adductor pollicis muscle. 12 young males (YM, 25.3 +/- 2.1 y), 12 young females (YF. 23.5 +/- 2.1 y), 12 older males (OM, 71.7 +/- 5.6 y) and 12 older females (OF, 69.5 +/- 4.6 y) participated. Three minutes of intermittent (5 s contraction, 2 s rest) maximal voluntary contractions (MVC) were used to fatigue the adductor pollicis muscle; the ulnar nerve was also stimulated in each 2 s rest period to evoke a maximal twitch. Males were stronger than females in both voluntary and evoked force (PT) in the young age group (MVC: YM, 10.0 +/- 2.7 kg vs. YF, 6.6 +/- 1.1 kg, P < 0.05) (PT: YM, 0.99 +/- 0.21 kg vs. YF, 0.71 +/- 0.12 kg, P < 0.05). In the older adults, however, males were stronger only in the evoked twitch (OM, 0.73 +/- 0.24 kg vs. OF, 0.48 +/- 0.07 kg, P < 0.05). There was no significant effect of gender or absolute muscle force on relative fatigability; the only variable found to significantly affect fatigability was age. Older adults were significantly less fatigable than young adults as indicated by the voluntary fatigue index (FI) (percentage of force reduction from baseline; FI-young, 40.2 +/- 12.6% vs. FI-old, 25.2 +/- 12.3%). This age effect, however, was more prominent in males than females (FI-YM, 44.7 +/- 10.5% vs. FI-OM, 24.2 +/- 10.7%, P < 0.01; FI-YF, 37.8 +/- 14.1% vs. FI-OF, 26.3 +/- 14.5%, P = 0.13). In conclusion, age was found to be the strongest single predictor of fatigability during short duration, intermittent exercise in human adductor pollicis muscle.
In Vitro Colony Formation by Normal and Leukemic Human Hematopoietic Cells: Characterization of the Colony-Forming Cells 2 (1973)

Journal Article In Vitro Colony Formation by Normal and Leukemic Human Hematopoietic Cells: Characterization of the Colony-Forming Cells Get access M. A. S. Moore, M. A. S. Moore Cancer Research Unit, The Walter and Eliza Hall Institute, Royal Melbourne Hospital, P.O. 3050, Victoria, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Williams, N. Williams Cancer Research Unit, The Walter and Eliza Hall Institute, Royal Melbourne Hospital, P.O. 3050, Victoria, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Metcalf D. Metcalf Cancer Research Unit, The Walter and Eliza Hall Institute, Royal Melbourne Hospital, P.O. 3050, Victoria, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 50, Issue 3, March 1973, Pages 603–623, https://doi.org/10.1093/jnci/50.3.603 Published: 01 March 1973 Article history Received: 01 June 1972 Accepted: 20 September 1972 Published: 01 March 1973
Multichannel adaptive blind deconvolution using the complex cepstrum of higher order cross-spectra (1993)

An adaptive cross-spectral blind deconvolution method, cross-TEA, for the case in which data are available from several sensors, is described. Unlike ordinary cross-spectra, higher order cross-spectra are separable, and this fact is used to identify and deconvolve each system. Cross-TEA was tested on four-channel QAM (quadrature amplitude modulation) signals, and the results are compared to those for TEA, an autospectral method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Test Compaction for Transition Faults under Transparent-Scan (2006)

Transparent-scan was proposed as an approach to test generation and test compaction for scan circuits. Its effectiveness was demonstrated earlier in reducing the test application time for stuck-at faults. We show that similar advantages exist when considering transition faults. We first show that a test sequence under the transparent-scan approach can imitate the application of broadside tests for transition faults. Test compaction can proceed similar to stuck-at faults by omitting test vectors from the test sequence. A new approach for enhancing test compaction is also described, whereby additional broadside tests are embedded in the transparent-scan sequence without increasing its length or reducing its fault coverage
Process Variation Sensitivity of Spin-Orbit Torque Perpendicular Nanomagnets in DBNs (2021)

Neuromorphic architectures with low energy barrier nanomagnetic devices have been attracting increasing interest over the past few years. More recently, a low barrier nanomagnet (LBNM)-based probabilistic device (p-bit) has been shown to be the basis of neuronal nodes in deep belief networks (DBNs). The LBNMs with perpendicular magnetic anisotropy (PMA) are analyzed and optimized in the interest of achieving stochasticity present in the learning system. In p-bit-based DBNs, several defects, such as variation of the nanomagnet diameter (σd), thickness (σt <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> ), and anisotropy field (σH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</sub> ), which results in alteration of the fluctuation speed of the p-bit's nanomagnet can impair functionality. In this article, the accuracy of p-bit-based DBNs is examined under variation of nanomagnet diameter, thickness, and anisotropy field for various tilt angles and temperatures. As evaluated for the MNIST data set for temperature and tilt angle of 300 K and 25°, accordingly, it is shown that the process variation (PV) of σd, σt <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> , and σH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</sub> can be tolerated up to 8%, 23%, and 25%, respectively. A new method is developed to control the fluctuation frequency of the output of a p-bit device by employing a feedback mechanism. The feedback can alleviate this PV sensitivity of p-bit-based DBNs. The compact and low complexity method, which is presented by introducing the self-compensating circuit, can alleviate the influences of PV in fabrication and practical implementation.
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice (2012)

Upper aerodigestive tract (UADT) cancers of the oral cavity and esophagus are a significant global health burden, and there is an urgent need to develop relevant animal models to identify chemopreventive and therapeutic strategies to combat these diseases. Antizyme (AZ) is a multifunctional negative regulator of cellular polyamine levels, and here, we evaluate the susceptibility of keratin 5 (K5)-AZ transgenic mice to tumor models that combine chemical carcinogenesis with dietary and genetic risk factors known to influence human susceptibility to UADT cancer and promote UADT carcinogenesis in mice. First, p53(+/-) and K5-AZ/p53(+/-) (AZ/p53(+/-)) mice were placed on a zinc-deficient (ZD) or zinc-sufficient (ZS) diet and chronically exposed to 4-nitroquinoline 1-oxide. Tongue tumor incidence, multiplicity and size were substantially reduced in both ZD and ZS AZ/p53(+/-) mice compared with p53(+/-). AZ expression also reduced progression to carcinoma in situ or invasive carcinoma and decreased expression of the squamous cell carcinoma biomarkers K14, cyclooxygenase-2 and metallothionein. Next, AZ-expressing p53(+/-) and p53 null mice were placed on the ZD diet and treated with a single dose of N-nitrosomethylbenzylamine. Regardless of p53 status, forestomach (FST) tumor incidence, multiplicity and size were greatly reduced with AZ expression, which was also associated with a significant decrease in FST epithelial thickness along with reduced proliferation marker K6 and increased differentiation marker loricrin. These studies demonstrate the powerful tumor suppressive effects of targeted AZ expression in two distinct and unique mouse models and validate the polyamine metabolic pathway as a target for chemoprevention of UADT cancers.
Seismic Strengthening of Unreinforced Masonry Walls using Sprayable Eco-Friendly Ductile Cementitious Composite (EDCC) (2017)

In another paper at this workshop, the development of Eco-Friendly Ductile Cementitious Composite (EDCC) and its response to uniaxial tensile is described. Here, its performance when used as a strengthening coat on unreinforced masonry is described. This paper elaborates on the results of shake table tests on full-scale masonry wall specimens, each about 2m wide by 3m high, retrofitted using sprayed EDCCs. Six full-scale unreinforced non-grouted masonry wall specimens were assembled and then retrofitted using Sprayable EDCC. The walls are tested at the Earthquake Engineering Research Facility (EERF) at UBC on the Linear Shake Table (LST) under different ground motions with varying intensities. The wall specimens were fully instrumented and data were collected using 34 different channels including 10 accelerometers, 8 channels of displacement sensors, 8 strain gauges and time synchronized video recording using eight HD cameras. Test indicated that even a single-sided retrofit with appropriate EDCC can significantly enhance the overall ductility of the system and change the fundamental behaviour of the wall from a typical “Rocking Mechanism” to a “Beam” type behaviour, with significant rotations at the hinge supports of the base. The added flexibility to the system resulted in a substantial increase in energy dissipation, and thereby increasing the overall drift limits before collapsing, causing the wall to withstand extensive levels of shaking under different types and intensities of earthquake generated ground motions.
Protein synthesis in hyper functioning human thyroid tissue (1980)

The rate of protein synthesis was examined in vitro in thyroid tissue slices. The material was obtained from euthyroid patients operated on for hyperparathyroidism and from hyperthyroid patients with Graves' disease pre-operatively treated with propranolol alone. The rate of protein synthesis was calculated from the incorporation of [3H]leucine radioactivity in the soluble thyroid proteins (mainly the colloid proteins), the amount of soluble protein per mg tissue and amount of DNA. Based on these figures it was observed that the rate of protein synthesis was 3.2 times higher in the hyperfunctioning thyroid tissue than in the normal tissue. A significant correlation was observed between this activity factor and the serum concentrating of thyroxine. It is concluded that the increased hormone formation in hyperthyroid Graves' disease at least partly depends on an increased rate of protein synthesis in the follicular epithelium. This could be due to stimulation by thyroid immunoglobulins, but other pathogenetic mechanisms may be responsible.
Purification of the Rat Hepatic α2-Macroglobulin Receptor as an Approximately 440-kDa Single Chain Protein (1989)

alpha 2-Macroglobulin-trypsin complex (alpha 2M.T) and alpha 2M-methylamine bind in a Ca2+-dependent way to a 400- to 500-kDa receptor in rat and human liver membranes (Gliemann, J., Davidsen, O., and Moestrup, S. K. (1989) Biochim. Biophys. Acta 980, 326-332). Here we report the preparation of alpha 2M receptors from rat liver membranes solubilized in 3-[(3-cholamidopropyl) dimethylammonio]-1-propane sulfonic acid (CHAPS) dihydrate and incubated with Sepharose-immobilized alpha 2M-methylamine. The receptor preparation eluted with EDTA (pH 6.0) contained a protein larger than the 360-kDa alpha 2M (nonreducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis) and some minor contaminants. The reduced large protein was about 440 kDa using reduced laminin (heavy chain: 400 kDa) as a standard. About 10 micrograms of receptor protein was obtained from 100 mg of liver membranes. The receptor preparation immobilized on nitrocellulose sheets bound 125I-alpha 2M.T, and the binding activity co-eluted with the 440-kDa protein. 125I-Labeled rat alpha 1-inhibitor-3 (alpha 1I3), a 200-kDa analogue of the alpha 2M subunit which binds to the alpha 2M receptors, was cross-linked to the 440-kDa protein. The receptor preparation was iodinated, and the 125I-labeled 440-kDa protein was isolated. It showed Ca2+-dependent saturable binding to alpha 2M-methylamine. In conclusion, we have purified the major hepatic alpha 2M receptor as an approximately 440-kDa single chain protein.
Fabrication Method for Nanocluster Superatoms with High-Power Impulse Magnetron Sputtering (2017)

Intensive ion source for single-size nanoclusters was developed on the basis of high-power impulse magnetron sputtering (HiPIMS) technique combined with a low-pressure, low-temperature gas flow reactor. The nanocluster source exhibits superior characteristics originating from pulsed, high-power sputtering compared to conventional direct-current sputtering; (1) enhanced ion intensities, (2) fascicle tuning of nanocluster sizes, and (3) enhanced selectivity of stable, magic nanoclusters. The metallic (silver, platinum, and palladium) and binary (transition-metal and silicon) nanocluster ions in the size range of several to one hundred atoms can be generated with ion current of 100 pA to 10 nA (108 to 1011 nanoclusters/sec). The growth mechanism of nanoclusters in the source was also explained by the nucleation theory.
Properties of PZT thick films made on LTCC (2005)

Purpose To find properties of screen printed PZT (PbZr 0.53 Ti 0.47 O 3 with 6 per cent of PbO and 2 per cent of Pb 5 Ge 3 O 11 ) thick films layers on LTCC substrate. Design/methodology/approach The influence of PZT firing time and electrode materials on electrical characteristics and microstructure were examined. A scanning electron microscope (SEM) equipped with an energy‐dispersive X‐ray (EDS) analyser was used for the microstructural and compositional analysis. Findings Microstructural and compositional analyses have shown the diffusion of SiO 2 from LTCC into PZT layers and the diffusion of PbO in the opposite direction. SiO 2 presumably forms low permitivity lead based silicates in PZT layer. The new phase deteriorates the piezoelectric properties. The amount of diffused materials was dependent upon the electrode material and increased with increasing firing time. Better properties, i.e. higher remanent polarisation and dielectric constant were achieved for samples with PdAg electrodes and shorter firing time. Originality/value New information on electrical and microstructural properties of thick film PZT made on LTCC substrate.
CORRELATION ENTRE CERVICOGRAPHIE ET CYTOLOGIE DANS LE DEPISTAGE DES LESIONS CERVICALES (1991)

SCOPUS: cp.j
KCTD10 Biology: An Adaptor for the Ubiquitin E3 Complex Meets Multiple Substrates (2020)

Protein ubiquitination constitutes a post-translational modification mediated by ubiquitin ligases whereby ubiquitinated substrates are degraded through the proteasomal or lysosomal pathways, or acquire novel molecular functions according to their "ubiquitin codes." Dysfunction of the ubiquitination process in cells causes various diseases such as cancers along with neurodegenerative, auto-immune/inflammatory, and metabolic diseases. KCTD10 functions as a substrate recognition receptor for cullin-3 (CUL3), a scaffold protein in RING-type ubiquitin ligase complexes. Recently, studies by ourselves and others have identified new substrates that are ubiquitinated by the CUL3/KCTD10 ubiquitin ligase complex. Moreover, the type of polyubiquitination (e.g., K27-, K48-, or K63-chain) of various substrates (e.g., RhoB, CEP97, EIF3D, and TRIF) mediated by KCTD10 underlies its divergent roles in endothelial barrier formation, primary cilium formation, plasma membrane dynamics, cell proliferation, and immune response. Here, the physiological functions of KCTD10 are summarized and potential mechanisms are proposed.