gebhart/patrepeval huggingface dataset:
Two-channel Kondo physics from tunneling impurities with triangular symmetry (1997)

Tunneling impurities in metals have been known for some time to have the potential for exhibiting Kondo-like physics. However, previous models based on an impurity hopping between two equivalent positions have run into trouble due to the existence of relevant operators that drive the system away from the non-Fermi-liquid Kondo fixed point. In the case of an impurity hopping among positions with higher symmetry, such as triangular symmetry, it is shown here that the non-Fermi-liquid behavior at low temperatures can be generic. Using various bosonization techniques, the fixed point is shown to be stable. However, unlike the conventional two-channel Kondo (2CK) model, it has four leading irrelevant operators, implying that while the form of the singular temperature dependence of physical quantities is similar to the 2CK model, there will not be simple universal amplitude ratios. The phase diagram of this system is analyzed and a critical manifold is found to separate the non-Fermi-liquid from a conventional Fermi liquid fixed point. Generalization to higher symmetries, such as cubic, and the possibility of physical realizations with dynamic Jahn-Teller impurities are discussed.
The extracellular matrix molecule tenascin‐R and its HNK‐1 carbohydrate modulate perisomatic inhibition and long‐term potentiation in the CA1 region of the hippocampus (2000)

Perisomatic inhibition of pyramidal cells regulates efferent signalling from the hippocampus. The striking presence of HNK-1, a carbohydrate expressed by neural adhesion molecules, on perisomatic interneurons and around somata of CA1 pyramidal neurons led us to apply monoclonal HNK-1 antibodies to acute murine hippocampal slices. Injection of these antibodies decreased GABAA receptor-mediated perisomatic inhibitory postsynaptic currents (pIPSCs) but did not affect dendritic IPSCs or excitatory postsynaptic currents. The decrease in the mean amplitude of evoked pIPSCs by HNK-1 antibodies was accompanied by an increase in the coefficient of variation of pIPSC amplitude, number of failures and changes in frequency but not amplitude of miniature IPSCs, suggesting that HNK-1 antibodies reduced efficacy of evoked GABA release. HNK-1 antibodies did not affect pIPSCs in knock-out mice deficient in the extracellular matrix molecule tenascin-R which carries the HNK-1 carbohydrate as analysed by immunoblotting in synaptosomal fractions prepared from the CA1 region of the hippocampus. For control, HNK-1 antibody was applied to acute sections of mice deficient in the neural cell adhesion molecule NCAM, another potential carrier of HNK-1, and resulted in decrease of pIPSCs as observed in wild-type mice. Reduction in perisomatic inhibition is expected to promote induction of long-term potentiation (LTP) by increasing the level of depolarization during theta-burst stimulation. Indeed, LTP was increased by HNK-1 antibody applied before stimulation. Moreover, LTP was reduced by an HNK-1 peptide mimic, but not control peptide. These results provide first evidence that tenascin-R and its associated HNK-1 carbohydrate modulate perisomatic inhibition and synaptic plasticity in the hippocampus.
Peptic ulcer in patients with liver cirrhosis: a retrospective endoscopic and clinical study. (1997)

This retrospective study confirms the high frequency of peptic ulcer in patients with liver cirrhosis. It also confirms that the peptic ulcer in these patients is very often asymptomatic and associated with concurrent complications, especially in those with more severe liver disease. The complication rate in recurrent ulcers was 20%-25%. However, due to the retrospective nature of this study, after ulcer healing the endoscopic follow-up was irregular. Regularly repeated endoscopy should be carried out in patients with liver cirrhosis and peptic ulcer to diagnose new and recurrent ulcers and to prevent related complications.
Chloramine-induced oxidative dimerization of phenols (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChloramine-induced oxidative dimerization of phenolsLeo A. Paquette and William C. FarleyCite this: J. Org. Chem. 1967, 32, 9, 2718–2723Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/jo01284a016https://doi.org/10.1021/jo01284a016research-articleACS PublicationsRequest reuse permissionsArticle Views255Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FIXATION MODE OF AN INTRA-OPERATIVE MANUFACTURED CUSTOM MADE PROSTHESIS STEM INFLUENCES OUTCOME OF TOTAL HIP REPLACEMENT (2008)

Success of a total hip replacement is commonly assessed by the Haris Hip Score (HHS), which provides information on pain reduction and regained mobility. Radiographic images provide information relative to the stability of the prosthesis. We use the intraoperatively manufactured prosthesis since 1989; the initially performed THR were done with uncoated prostheses. After introduction of the hydroxyapatite coating our prosthesis stems were coated. We retrospectively evaluated the clinical and radiographic outcome of 3 patient cohorts who received intra-operatively custom made stem prosthesis. Group 1: Uncoated stem prosthesis fixated with tro-chanteric osteotomy. Group 2: Uncoated stem cementless implant Group 3: Cementless hydroxyapatite coated stem prosthesis Clinical assessment and radiographic assessment is performed using pre-operatively and at each follow-up visit. Baseline data are the pre-operative HHS and first radiography postoperatively. These data are compared with the data of the latest follow-up visit. RX’s are scored according to the ARA score. Records were analysed for 83 patients in group 1, with a mean follow-up period of 93 months. In group 2, 35 patients were followed for 105 months and 54 patients from group 3 were followed for 41 months. In the 3 groups the HHS at follow-up was > 75, this means an improvement of minimum 25 points for group 1 and 2 (baseline HHS for group 2 was not available) The mean ARA scores at follow-up were 1.6; 1.7 and 5.3 for respectively group 1; 2 and 3. Clinical outcome is comparable in the three studied cohorts. The ARA score is indicating poor outcome for the uncoated prosthesis, regardless of the type of fixation, while the coated prosthesis group has a good to excellent ARA score. These findings tend to confirm the superiority of the hydroxyapatite coated prosthesis.
Making the smart grid work for community energy delivery (2011)

Many municipal and community owned electrical distribution systems are under pressure to demonstrate progress towards attaining energy efficiency and sustainability goals. Fueled by general public interest, and a strong environmental and vendor lobby the "Smart Grid" has become a rallyi ng point for attaining triple bottom line goals for utility departments. While larger distribution systems have the means to pursue more visible initiatives, smaller and mid-tier municipalities are challenged with the reality that conservation and sustainability is expensive, and may in fact be beyond their means. This paper presents the experiences of several small to mid-tier municipal or community owned electrical systems in realizing their conservation and sustainability goals through the implementation of a smart grid.
DNA hypermethylation and histone hypoacetylation of the HLTF gene is associated with reduced expression in gastric carcinoma (2004)

4169 The SWI/SNF proteins are ATP-dependent chromatin remodeling enzymes that have been implicated in the regulation of gene expression. Recent studies have shown that members of the SWI/SNF superfamily can function as tumor suppressor genes. DNA methylation and transcriptional inactivation of the HLTF gene, which is a homologue to SWI/SNF genes, have been shown in colon cancer. In the present study, we studied the DNA methylation status of the HLTF gene by methylation-specific PCR in 50 gastric carcinoma tissues, and seven gastric carcinoma cell lines and compared methylation status with levels of HLTF mRNA expression. DNA methylation of the HLTF gene was found in 25 (50%) of 50 gastric carcinomas, and levels of HLTF mRNA were associated with methylation status of HLTF (p = 0.027; Mann-Whitney U test). There were no correlations between HLTF mRNA levels and DNA methylation and T grade, N grade, tumor stage, or histological type. In corresponding non-neoplastic mucosae, DNA methylation of the HLTF gene was found in 1(7%) of 15 samples. The methylated allele was not detected in any of 10 normal gastric mucosae from 10 young healthy volunteers. Among seven gastric carcinoma cell lines, the KATO-III cell line showed loss of HLTF mRNA expression associated with DNA methylation. This loss was rectified by treatment with both Aza-2’-deoxycytidine, a demethylating agent, and trichostatin A, a histone deacetylase inhibitor. Chromatin immunoprecipitation assay revealed that the acetylation levels of histones H3 and H4 in the 5’ CpG island of the HLTF gene were inversely associated with DNA methylation status. These results suggest that transcriptional inactivation of HLTF by aberrant DNA methylation and histone deacetylation may be involved in stomach carcinogenesis through down-regulation of HLTF expression.
Synthesis, structure, and properties of hybrid organic-inorganic composites based on polysiloxanes. I. Poly(dimethylsiloxane) elastomers containing silica (1998)

Various synthetic protocols were used to prepare several classes of polysiloxane–silica filler systems. The structures of these fillers and their interactions with the polysiloxane matrices were studied using small-angle X-ray and neutron scattering. In addition, the mechanical properties of the composites were characterized using equilibrium stress–strain isotherms in elongation. The results indicated that manipulation of the chemical reactions used to generate the filler can lead to a wide range of complex structures and unusual properties. Some of the observed mechanical properties were correlated with information on the composite structures and on elastomer–filler interactions. © 1998 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 36: 1167–1189, 1998
Site-specific and random degenerate rearrangements in η<sup>6</sup>- and η<sup>4</sup>-cycloheptatriene metal complexes (1982)

Carbon-13- labelled cycloheptatriene, containing 13C at the 3- and 7-positions, was synthesised from [13C-carboxy]-1,4-dihydrobenzoic acid by successive lithium aluminium hydride reduction, toluene-p-sulphonylation, and solvolysis in acetic acid. This was converted into the corresponding tricarbonylmolybdenum complex, which was subjected to thermolysis in [2H6]benzene solution. The course of reaction was followed by 13C n.m.r. spectroscopy, and the redistribution of isotopic label in the product compared with that predicted from solving the differential equations describing the kinetics for each of the possible rearrangement pathways. It was thus shown that a [1,5] hydride shift is involved, in keeping with earlier conclusions of Pauson but not with the observations of Grimme and Roth, or those of Faller. Isotopically enriched cycloheptatrienerhodium(I) acetylacetonate was prepared similarly, and its thermal degenerate rearrangement shown to occur with random redistribution of the label.
IgE-mediated desensitization in human basophils and mast cells (1998)

Secretion from mast cells and basophils, two cells central to immediate hypersensitivity reactions, has characteristics that suggest the existence of intrinsic signal transduction processes that limit the extent of the cell's response. This process(es) has been termed desensitization. One goal of current research efforts is to determine the mechanisms used by mast cells and basophils to down-regulate an ongoing secretory reaction. Recent studies have indicated that, like secretion itself, the mechanisms of down-regulation or desensitization differ according to the mediator being studied. Thus, for human basophils, there appear to be distinct signaling pathways leading to the secretion of the three major classes of mediators--granules contents, lipids, and cytokines--and each pathway appears to have distinct down-regulatory processes. For an ongoing secretory reaction, the secretion of histamine and LTC4 are limited by a process that does not involve the earliest steps in activation, activation of the early tyrosine kinases, lyn and syk. These early events persist for long periods which more appropriately correspond to the regulation of cytokine secretion. Recent studies have also indicated that the process of desensitization is altered during stimulation in the absence of extracellular calcium, the traditional method of examining this process. These studies indicate that down-regulation studied in this manner is not dependent on any of the signaling events currently defined as being necessary for secretion. A variety of processes are discussed and potential mechanisms based on most recent studies using cell lines are explored.
Total Syntheses of 10-Methoxydihydrocorynantheol and 10-Methoxycorynantheidol (1996)

10-Methoxydihydrocorynantheol and 10-methoxycorynantheidol were synthesized from 5-methoxytryptophol and 3-acetylpyridine. (13)C-NMR data of the prepared compounds and their synthetic intermediates are given.
Characterization of the macromolecule baseline in localized <sup>1</sup>H‐MR spectra of human brain (2001)

Short-echo-time magnetic resonance spectra of human brain contain broad contributions from macromolecules. As they are a priori of unknown shape and intensity, they pose a problem if one wants to quantitate the overlying spectral features from low-molecular-weight metabolites. On the other hand, the macromolecular contributions may provide relevant clinical information themselves, if properly evaluated. Several methods, based on T(1), T(2), or spectral shape, have previously been suggested to suppress or edit the macromolecule contributions. Here, a method is presented based on a series of saturation recovery scans and that allows for simultaneous recording of the macromolecular baseline and the fully relaxed metabolite spectrum. In comparison to an inversion recovery technique aimed at nulling signals from long-T(1) components, the saturation recovery method is less susceptible to T(1) differences inherent in signals from different metabolites or introduced by pathology. The saturation recovery method was used to quantitate the macromolecular baseline in white and/or gray matter locations of the human brain in 40 subjects. It was found that the content and composition of MR visible macromolecules depends on cerebral location, as well as the age of the investigated subject, while no gender dependence could be found.
Mirage-effect measurement of thermal diffusivity. Part II: theory (1986)

A three-dimensional theory of a mirage-effect technique for measuring thermal diffusivity of solids is presented. A formula that incorporates sizes and separations of the heating and probe beams; the height of the probe beam above the sample surface; the thermal properties of the sample, the gas, and the backing; and the thickness of the sample is developed. The results are compared with experiments on a bulk sample and on thin slabs of various thicknesses.
Multi-gigahertz low-power low-skew rotary clock scheme (2002)

On-chip clock frequencies in the gigaHertz range require generators with low skew and low jitter to avoid timing problems. This rotary clock distribution architecture provides low-skew low-jitter, gigaHertz-rate clocking with high edge rates and low power consumption, works over a wide power supply range and is completely scalable. The frequency is limited only by f/sub T/ of the integrated circuit technology used; an f/sub T/ of approximately 30 GHz produces square waves with 20 ps transition times. In addition, there is no limit to the size of the chip that can be clocked, and both multiphase and non-overlapping noise-immune differential clocking are supported.
Comparison of the esterase and human plasminogen activator activities of various activated forms of human plasminogen and their equimolar streptokinase complexes. (1977)

A comparison was made of the esterase and activator activities of the various activated forms of human plasminogen and their streptokinase complexes with Nalpha-Cbz-L-lysine-p-nitrophenyl ester as the substrate. The steady state kinetic properties of Glu- and Lys-plasmins, and Glu- and Lys-plasminogen-streptokinase complexes were identical, while the Lys-plasmin-streptokinase complex showed a 2-fold increase in Km with the same kcat and a 3-fold increase in Ki for the competitive inhibitor leupeptin. Lys-plasminogen (zymogen with an active site) was prepared which incorporated 0.7 mol of [3H]idisopropyl phosphorofluoridate and 0.43 mol of p-nitrophenyl-p'-guanidinobenzoate/mol of protein. The Km for Lys-plasminogen was 3-fold higher than that of Lys-plasmin, and its maximum velocity 10-fold lower. The steady state kinetic parameters of a plasmin-derived light (B) chain (CmCys)3, and a derived equimolar light (B) chain-streptokinase complex (CmCys)3, isolated from human plasmin and equimolar plasmin-streptokinase, or plasminogen-streptokinase, complexes, respectively, were determined. When the light (B) chain-streptokinase complex is isolated from its parent complexes, there is a complete retention of the original parent's esterase activities, with respect to Km and kcat, and interaction with the competitive inhibitors benzamidine and leupeptin. The plasmin-derived light (B) chain does not retain its parent esterase activities. This chain has very similar kinetic properties to Lys-plasminogen except that streptokinase, in an equal molar amount, does not impart full esterase activity to the light (B) chain whereas the zymogen can be completely activated by streptokinase. The kcat of the plasmin-derived light (B) chain, and its streptokinase complex can be enhanced by 50 and 30%, respectively, in the presence of 10(-4) M leupeptin, a competitive inhibitor of plasmin, attesting to the increased structural flexibility within the active site of this enzyme species. Urokinase hydrolyzes Nalpha-Cbz-L-lysine p-nitrophenyl ester efficiently with a kcat/Km of one-third that of plasmin. The human plasminogen activator activities of various activated forms of human plasminogen and their equimolar streptokinase complexes were compared in a kinetic assay. The Lys-plasmin-streptokinase complex, and streptokinase were the least active of the activator species and were approximately equal in their activator activities. Glu- and Lys-plasminogen-streptokinase complexes had approximately 1.5 times the activity of streptokinase, whereas the equimolar light (B) chain-streptokinase complexes had approximately 2- to 3-times the activator activity of streptokinase. Since the esterase activity remained unchanged, this indicates a greater degree of specificity in the active site of the equimolar light (B) chain-streptokinase activator complex. Urokinase proved to be a poor activator species...
Experimental and numerical investigation of the competition between axisymmetric time-periodic modes in an enclosed swirling flow (2006)

Time-periodic vortex flows in an enclosed circular cylinder driven by the rotation of one endwall are investigated experimentally and numerically. This work is motivated partly by the linear stability analysis of Gelfgat et al. [J. Fluid Mech. 438, 363 (2001)], which showed the existence of an axisymmetric double Hopf bifurcation, and the purpose of the experiment is to see if the nonlinear dynamics associated with this double Hopf bifurcation can be captured under laboratory conditions. A glycerin/water mixture was used in a cylinder with variable height-to-radius ratios between Γ=1.67 and 1.81, and Reynolds numbers between Re=2600 and 2800 (i.e., in the neighborhood of the double Hopf). Hot-film measurements provide, for the first time, experimental evidence of the existence of an axisymmetric double Hopf bifurcation, involving the competition between two stable coexisting axisymmetric limit cycles with periods (nondimensionalized by the rotation rate of the endwall) of approximately 31 and 22. The dynamics is also captured in our nonlinear computations, which clearly identify the double Hopf bifurcation as “type I simple,” with the characteristic signatures that the two Hopf bifurcations are supercritical and that there is a wedge-shaped region in (Γ,Re) parameter space where both limit cycles are stable, delimited by Neimark-Sacker bifurcation curves.
A new HLA‐B44 variant (B44BO [B*4408]) identified by serology (1997)

Using HLA serology, we detected a new variant of HLA-B44- B44BO- in two families. This antigen reacts with B44 antisera and is negative with over one-third of B12 (B44, B45) sera but reacts with 50% antisera with a B62 component, especially if they contain anti-B57. The variant, B*4408, differs from the common B*4402 by 4 nucleotide substitutions in exon 2: 193, 206 and 209, which produce changes in the the alpha 1 domain at positions 41, 45 and 46 (TKE in B*4402 and AMA in B44BO); and nucleotide 213, a silent substitution. At each of these positions, B*4408 is identical to B*46 B*57 and may B*15 alleles. As anticipated from its predicted iso-electric point (5.71), one-dimensional isoelectric focusing studies showed that B44BO focuses at the same position as B*4402. The sequence and serological reactivity of this rare antigen allowed the identification of two likely epitopes shared by two different groups of HLA-B antigens.