gebhart/patrepeval huggingface dataset:
Event-Based Modeling with High-Dimensional Imaging Biomarkers for\n Estimating Spatial Progression of Dementia (2019)

Event-based models (EBM) are a class of disease progression models that can\nbe used to estimate temporal ordering of neuropathological changes from\ncross-sectional data. Current EBMs only handle scalar biomarkers, such as\nregional volumes, as inputs. However, regional aggregates are a crude summary\nof the underlying high-resolution images, potentially limiting the accuracy of\nEBM. Therefore, we propose a novel method that exploits high-dimensional\nvoxel-wise imaging biomarkers: n-dimensional discriminative EBM (nDEBM). nDEBM\nis based on an insight that mixture modeling, which is a key element of\nconventional EBMs, can be replaced by a more scalable semi-supervised support\nvector machine (SVM) approach. This SVM is used to estimate the degree of\nabnormality of each region which is then used to obtain subject-specific\ndisease progression patterns. These patterns are in turn used for estimating\nthe mean ordering by fitting a generalized Mallows model. In order to validate\nthe biomarker ordering obtained using nDEBM, we also present a framework for\nSimulation of Imaging Biomarkers' Temporal Evolution (SImBioTE) that mimics\nneurodegeneration in brain regions. SImBioTE trains variational auto-encoders\n(VAE) in different brain regions independently to simulate images at varying\nstages of disease progression. We also validate nDEBM clinically using data\nfrom the Alzheimer's Disease Neuroimaging Initiative (ADNI). In both\nexperiments, nDEBM using high-dimensional features gave better performance than\nstate-of-the-art EBM methods using regional volume biomarkers. This suggests\nthat nDEBM is a promising approach for disease progression modeling.\n
Daily Haemodialysis in “Hypercatabolic” Acute Renal Failure (1964)

<h3>Abstract</h3> The main carotenoid in the extremely radiation-resistant bacterium <i>Deinococcus radiodurans</i> is deinoxanthin. In this paper, based on UV-Vis, MS/MS spectra as well as the chemical properties, the other main two carotenoids in this bacterium were identified as ((all-E)-1’-hydroxy-3’,4’-didehydro-1’,2’-dihydro-β,Ψ-carotene- 4-one-1), and ((all-E)-1’-hydroxy-3’,4’-didehydro-1’,2’,2,3-quahydro-β,Ψ-carotene- 4-one-1), respectively. The fully structure elucidation for the carotenoids should help to gain a better understanding of the radiation-resistant mechanisms in this remarkable bacterium.
THE LASER EMITTANCE SCANNER FOR 1 GEV H- BEAM (2009)

A transverse phase space laser emittance scanner is proposed [1] and under development for the 1-GeV H- SNS linac, using a laser beam as a slit. For a 1-GeV H- beam, it is difficult to build a slit because the stopping distance is more than 50 cm in copper. We propose a Laser Emittance Scanner (LES) to use a laser beam as an effective slit by stripping off the outer electron of the H- (making it neutral) upstream of a bend magnet and measuring the stripped component downstream of the bend magnet. The design and modeling of the system will be discussed. We are expecting to make a preliminary measurement in 2009.
ChemInform Abstract: Synthesis of Aziridine‐2‐carboxylates via Conjugate Addition of an Amine to 2‐(5H)‐Furanon‐3‐yl Methanesulfonate: Application to the Preparation of α‐Amino‐β‐hydroxy‐γ‐butyrolactone. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Activity of esorubicin in recurrent malignant lymphoma: a Southwest Oncology Group study. (1991)

A phase II trial of esorubicin (4' deoxydoxorubicin) was conducted by the Southwest Oncology Group in 88 assessable patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) at the time of first relapse. Esorubicin was administered at two dose levels: 25 mg/m2 for patients at risk for excessive myelosuppression, and at 30 mg/m2 for all others at 21-day intervals. Overall, 33 of 88 patients (38%) responded to treatment including three complete remissions (CRs; 3%) and 30 partial remissions (PRs; 34%), with the median duration of response lasting 6.2 months. Response rates did not differ significantly by histologic subtype: 31% of 26 patients with favorable NHL, 33% of 43 patients with unfavorable NHL, and 58% of 19 patients with HD. Twelve of 33 responding patients (36%) had relatively durable remissions lasting from 1 to more than 4 years. Leukopenia (less than 3,000 cells per microliter) was seen in 65 of 88 patients (74%) and was severe (less than 1,000 cells per microliter) in 20 of 88 patients (23%). Clinical signs or symptoms of congestive heart failure were not seen and the ejection fraction (EF) fell 10% to 20% in three patients. Esorubicin is an active agent in patients with NHL or HD at the time of first relapse.
Comparative Methylprednisolone Pharmacokinetics in Renal Transplant Patients Receiving Double- or Triple-Drug Immunosuppression (1993)

These data indicate that cyclosporine had no definitive influence on methylprednisolone disposition. The results reveal a wide variation in methylprednisolone metabolism in renal transplant recipients receiving either a double- or triple-drug immunosuppressive regimen. Typically, methylprednisolone is prescribed according to a standardized dosing protocol that assumes minimal interpatient variation. Therefore, the pharmacokinetic variability noted in this study may have important clinical implications regarding the development of chronic toxicity (e.g., osteoporosis, hypothalamic-pituitary-adrenal suppression) and the attainment of successful immunosuppression.
Slipped Capital Femoral Epiphysis (1991)

Slipped capital femoral epiphysis (SCFE) is an unusual disorder in which the epiphysis of the proximal femur slips through the growth plate in a posterior direction. Significant derangement of hip function results and can be accompanied by two complications: avascular necrosis and chondrolysis. The cause remains elusive although many theories have been advanced. This article provides an overview of the disease process, diagnostic guidelines, and current treatment considerations. A case study is included.
Acute Effects of a New Stimulatory Luteinizing Hormone-releasing Hormone Analogue D-Ser(TBU)<sup>6</sup>-EA<sup>10</sup>-LRH on the Gonadotrophin and Gonadal Steroid Secretion in Women with Amenorrhoea (1977)

A new stimulatory luteinizing hormone-releasing hormone (LRH) analogue D-Ser(TBU)(6)-EA(10)-LRH was administered subcutaneously in a dose of 10 microg into 10 women with amenorrhoea. The injection resulted in a 20-fold increase of the LH level in blood and a 5-fold increase of the FSH level with maxima at 4 and 6 h after the administration, respectively. There was an evident biphasic pattern of LH release similar to that described after extended pituitary stimulation by constant infusions of LRH with early and late peaks of LH combined with a gradual, progressive FSH release. The duration of the effect on LH and FSH was at least 12 and 24 h, respectively. All the women responded with evident oestradiol increases in blood during the last 18 h of the 24 h study period. A comparison between the effects of a single subcutaneous injection of 10 microg of the LRH analogue and 500 microg of LRH showed that the initial FSH and LH release was similar. However, the FSH and LH release during the remainder of the study period was significantly greater after administration of the analogue and so was the oestradiol increase. Thus, this study in women confirms previous studies in men that D-Ser(TBU)(6)-EA(10)-LRH is a potent stimulatory LRH analogue with prolonged biological activity.
Metal catalyzed cross-coupling of aryl and benzyl methyl sulfides: nickel catalyzed C<sub>aryl</sub>–C<sub>sp3</sub> and C<sub>sp3</sub>–C<sub>sp3</sub> bond formations (2015)

The nickel catalyzed functionalization of C<sub>Ar</sub>–SMe and C<sub>sp3</sub>–SMe bonds by direct exchange of the sulfur atom with an activated sp<sup>3</sup>-carbon has been developed. The protocol allows the conversion of aryl and benzyl methyl sulfides to trimethylsilylated products in good yields.
Pendred Syndrome (2003)

Pendred syndrome is characterized by sensorineural deafness, goitre and cochlear malformations inherited in an autosomal recessive manner. Since the syndrome was first recognized, great phenotypic variability has been noted even within families. The causative gene, SLC26A4 (also known as PDS) was recently cloned and has been shown to account for the majority of cases of Pendred syndrome. The encoded protein, pendrin, is an anion transporter that mediates the exchange of chloride, iodide and formate. In the thyroid gland, it localizes to the apical membrane of thyrocytes; in the kidney, to the cortical collecting ducts; and in the inner ear, to the external sulcus and the endolymphatic duct. Mutation screening of SLC26A4 is clinically available making a genetic diagnosis possible and facilitating genetic counselling.
Application of Diffuse Mismatch Theory to the Prediction of Thermal Boundary Resistance in Thin-Film High-Tc Superconductors (1996)

Abstract Thermal boundary resistance (Rb) plays an important role in the design and performance of thin-film high-temperature superconducting devices, such as infrared detectors and optical switches, which rely upon the temperature rise of the film as the basis for their operation. Although there is general agreement on the magnitude of Rb from experimental data, there is at present no generally accepted theory capable of predicting Rb for these films, particularly at the intermediate cryogenic temperatures where they are likely to be used. Here, the Diffuse Mismatch Model (DMM), which considers that all phonons reaching the interface between the film and substrate scatter diffusely, is applied to the calculation of Rb. The results indicate that although the DMM yields results slightly more in agreement with data than the Acoustic Mismatch Model (AMM), the experimental data lie far above the calculated values. Removing the assumptions involved in the derivation of the DMM in some cases improves the agreement with the experimental data, but additional features must be incorporated into the model to achieve quantitative agreement between theory and experiment.
Local Control of Acetylcholinesterase Gene Expression in Multinucleated Skeletal Muscle Fibers: Individual Nuclei Respond to Signals from the Overlying Plasma Membrane (2000)

Nuclei in multinucleated skeletal muscle fibers are capable of expressing different sets of muscle-specific genes depending on their locations within the fiber. Here we test the hypothesis that each nucleus can behave autonomously and responds to signals generated locally on the plasma membrane. We used acetylcholinesterase (AChE) as a marker because its transcripts and protein are concentrated at the neuromuscular and myotendenous junctions. First, we show that tetrodotoxin (TTX) reversibly suppresses accumulation of cell surface AChE clusters, whereas veratridine or scorpion venom (ScVn) increase them. AChE mRNA levels are also regulated by membrane depolarization. We then designed chambered cultures that allow application of sodium channel agonists or antagonists to restricted regions of the myotube surface. When a segment of myotube is exposed to TTX, AChE cluster formation is suppressed only on that region. Conversely, ScVn increases AChE cluster formation only where in contact with the muscle surface. Likewise, both the synthesis and secretion of AChE are shown to be locally regulated. Moreover, using in situ hybridization, we show that the perinuclear accumulation of AChE transcripts also depends on signals that each nucleus receives locally. Thus AChE can be up- and downregulated in adjacent regions of the same myotubes. These results indicate that individual nuclei are responding to locally generated signals for cues regulating gene expression.
Compositional, Physical, Antioxidant and Sensory Characteristics of Novel Syrup from Date Palm (Phoenix dactylifera L.) (2009)

This study is a contribution to valorise date palm sap (Phoenix dactylifera L.) by elaboration of high quality syrup. Sap was concentrated by evaporation and the obtained product was characterized by its physicochemical, rheological, thermal, sensory properties and by its antioxidant activity. Syrups from date palm sap have a good nutritional value marked by high amounts of sugars (58—75 g/100 g fresh matter basis), minerals (2.1—2.6 g/100 g fresh matter basis) and phenolics (147.61—224.55 mg of ferulic acid equivalents/kg fresh weight). Syrup also presents an antioxidant activity that appears related to total phenolic content. Rheological properties indicate that syrup preserves a Newtonian behavior from 10 ° C to 55 ° C well modeled by Arrhenius equation. Hedonic evaluation showed that consumers’ appreciation of date palm syrup was not significantly different to the most known sap syrup: maple syrup.
Improved Synthesis and Characterization of ω-Primary Amino-Functional Polystyrenes and Polydienes (2002)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTImproved Synthesis and Characterization of ω-Primary Amino-Functional Polystyrenes and PolydienesHildegard Kukula, Helmut Schlaad, Jana Falkenhagen, and Ralph-Peter KrügerView Author Information Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Abteilung Kolloidchemie, Am Mühlenberg 1, D-14476 Golm, Germany Bundesanstalt für Materialforschung und -prüfung, Fachgruppe VI.3, Unter den Eichen 87, D-12205 Berlin, Germany Cite this: Macromolecules 2002, 35, 18, 7157–7160Publication Date (Web):August 2, 2002Publication History Received20 March 2002Revised21 June 2002Published online2 August 2002Published inissue 1 August 2002https://pubs.acs.org/doi/10.1021/ma0204397https://doi.org/10.1021/ma0204397brief-reportACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views555Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Mixtures,Polymer solutions,Polymers,Styrenes Get e-Alerts
ChemInform Abstract: KVTeO<sub>5</sub> and a Redetermination of the Na Homologue. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adjacent UCST Phase Behavior in Aqueous Solutions of Poly(vinyl methyl ether): Detection of a Narrow Low Temperature UCST in the Lower Concentration Range (2011)

We provide the first experimental evidence for the existence of a low concentration narrow UCST miscibility gap, which is the second of two narrow miscibility gaps constituting together adjacent UCST phase behavior. The existence of adjacent UCST miscibility phase behavior in aqueous polymer solutions has been theoretically predicted, but so far escaped experimental verification. We have been able to determine the low concentration narrow UCST miscibility gaps from the changes in apparent heat capacity observed in stepwise isothermal cooling modulated temperature differential scanning calorimetry (MTDSC) experiments. In wide-angle X-ray diffraction (WAXD) experiments it was unambiguously demonstrated that the MTDSC heat capacity changes are not due to crystallization. Together with earlier experimental results on the high concentration narrow UCST miscibility gap, the bimodal LCST miscibility gap and the sigmoidal melting line of ice the experimental results reported in this work complete the full experimental verification of the predicted complex phase behavior of aqueous solutions of PVME. As far as the authors are aware, this is the first system where adjacent UCST phase behavior is found. On the basis of the theoretical predictions the observed phase behavior could be more general and other systems may exist where similar behavior can be observed.
Kinins (1987)

Kinins are a group of peptides released in blood by kallikreins to exert a variety of biological actions by activating at least two different receptor types. B1 and B2 receptors for kinins have been identified with agonists and antagonists, in classical pharmacological assays. The existence of the two receptor types has been confirmed with binding assays, using labelled bradykinin and des Arg9 bradykinin. Antagonists for kinins active on B1 receptors have been identified and further developed to fairly potent, specific and competitive blockers. B2 receptors antagonists have recently been found and they are specific, but rather weak and nonselective, since they also block B1 receptors. B2 receptors mediate a large number of rapidly occurring biological effects, particularly the symptoms and signs of inflammation, while B1 receptors appear to be involved in some retarded, long lasting effects of kinins, such as collagen synthesis and cell multiplication. Kinins are among the naturally occurring agents involved in inflammatory reactions. All the processes of kinin generation appear to be accentuated: the expression of prekininogen mRNA; the production of kinin precursors (kinonogens) by the liver; the activation of the generating enzymes, the kallikreins; and the local production of kinins in inflammatory exudates. The kinins generated locally contribute to the acute and possibly the chronic phase of the inflammatory reaction by producing vasodilation, local oedema and pain. Kinins may also modulate migration of white blood and tissue cells that take part to the inflammatory process.
High performance surface acoustic resonators in 1&#x2013;3 GHz range using ScAlN/6H-SiC structure (2012)

This paper describes application of Sc-doped AlN (ScAlN) to wideband surface acoustic wave (SAW) devices in 1–3 GHz range. First, it is shown theoretically that large SAW velocity and electromechanical coupling factor are simultaneously achievable when the ScAlN is combined with a base substrate with extremely high acoustic wave velocities such as diamond and SiC. Next, SAW delay lines are fabricated on the ScAlN/6H-SiC structure, and it is shown that SAW properties are simulated well theoretically. Finally, one-port SAW resonators are fabricated on the structure, and it is shown how high performances are achievable in 1–3 GHz range by use of the structure.
Influence of DTPA Therapy on Long-Term Effects of Retained Monomeric Plutonium: Comparison with Polymeric Plutonium (1967)

Marcia W. Rosenthal, Arthur Lindenbaum, Influence of DTPA Therapy on Long-Term Effects of Retained Monomeric Plutonium: Comparison with Polymeric Plutonium, Radiation Research, Vol. 31, No. 3 (Jul., 1967), pp. 506-521
Partial evidence for the existence of mitogenetic radiation (1997)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Catalytic oxidation of hydrogen sulfide on iron oxides (1983)

A flow-through reactor with a vibrofluidized catalyst bed was used to study the activity of iron oxide in the oxidation of hydrogen sulfide. The nature of the starting materials used for the preparation of iron oxide catalysts had little apparent effect on their activity. Up to 576/sup 0/F, iron oxide catalysts selectively oxidized hydrogen sulfide to elemental sulfur in the presence of methane while the latter remained unchanged. A study of the oxidation kinetics produced a reaction-rate equation that agreed with the experimental data.
Génomique fonctionnelle des interactions virus-cellule et réponse immunitaire innée chez le porc : étude dans plusieurs modèles cellulaires infectés par un Herpes-virus (2005)

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