gebhart/patrepeval huggingface dataset:
Direction of active sliding of microtubules in Tetrahymena cilia. (1977)

Axonemes of protozoan (Tetrahymena thermophila BIII) cilia, isolated by the dibucaine method, were treated briefly with trypsin after removal of the ciliary membranes by treatment with Triton X-100. After attachment to polylysine-coated surfaces, the partially digested axonemes remained mainly intact cylinders. Such attached axonemes can be treated with ATP, which induces microtubles sliding. ATP-treated preparations showed disrupted axonemes in which doublets had telescoped out of the original cylinders. These could be captured in place for electron microscopy after critical point drying. Images of this type were used to determine relative movement between adjacent doublet microtubules. Each doublet actively slid relative to its neighbors in a single direction, in which the polarity of force generation of the dynein arms was from base to tip.
Aseptic Necrosis of the Femoral Head and Non-Union of the Femoral Neck (1968)

A long-term evaluation has been made of the effect of drilling and bone-grafting for aseptic necrosis of the femoral head with or without union of the fractured femoral neck, idiopathic aseptic necrosis of the femoral head, and aseptic necrosis of the femoral head caused by traumatic dislocation. One hundred and twelve patients were followed for from two to fifteen years. The results show that the procedure is effective in restoring viability to the necrotic femoral head and continuity to the ununited femoral-neck fracture in a sufficient number of patients (78.4 per cent) to warrant its continued use in the management of these complications.
A Method for Biomolecular Structural Recognition and Docking Allowing Conformational Flexibility (1998)

In this work, we present an algorithm developed to handle biomolecular structural recognition problems, as part of an interdisciplinary research endeavor of the Computer Vision and Molecular Biology fields. A key problem in rational drug design and in biomolecular structural recognition is the generation of binding modes between two molecules, also known as molecular docking. Geometrical fitness is a necessary condition for molecular interaction. Hence, docking a ligand (e.g., a drug molecule or a protein molecule), to a protein receptor (e.g., enzyme), involves recognition of molecular surfaces. Conformational transitions by "hinge-bending" involves rotational movements of relatively rigid parts with respect to each other. The generation of docked binding modes between two associating molecules depends on their three dimensional structures (3-D) and their conformational flexibility. In comparison to the particular case of rigid-body docking, the computational difficulty grows considerably when taking into account the additional degrees of freedom intrinsic to the flexible molecular docking problem. Previous docking techniques have enabled hinge movements only within small ligands. Partial flexibility in the receptor molecule is enabled by a few techniques. Hinge-bending motions of protein receptors domains are not addressed by these methods, although these types of transitions are significant, e.g., in enzymes activity. Our approach allows hinge induced motions to exist in either the receptor or the ligand molecules of diverse sizes. We allow domains/subdomains/group of atoms movements in either of the associating molecules. We achieve this by adapting a technique developed in Computer Vision and Robotics for the efficient recognition of partially occluded articulated objects. These types of objects consist of rigid parts which are connected by rotary joints (hinges). Our method is based on an extension and generalization of the Hough transform and the Geometric Hashing paradigms for rigid object recognition. We show experimental results obtained by the successful application of the algorithm to cases of bound and unbound molecular complexes, yielding fast matching times. While the "correct" molecular conformations of the known complexes are obtained with small RMS distances, additional, predictive good-fitting binding modes are generated as well. We conclude by discussing the algorithm's implications and extensions, as well as its application to investigations of protein structures in Molecular Biology and recognition problems in Computer Vision.
Semi-Supervised Heterogeneous Fusion for Multimedia Data Co-Clustering (2013)

Co-clustering is a commonly used technique for tapping the rich meta-information of multimedia web documents, including category, annotation, and description, for associative discovery. However, most co-clustering methods proposed for heterogeneous data do not consider the representation problem of short and noisy text and their performance is limited by the empirical weighting of the multi-modal features. In this paper, we propose a generalized form of Heterogeneous Fusion Adaptive Resonance Theory, called GHF-ART, for co-clustering of large-scale web multimedia documents. By extending the two-channel Heterogeneous Fusion ART (HF-ART) to multiple channels, GHF-ART is designed to handle multimedia data with an arbitrarily rich level of meta-information. For handling short and noisy text, GHF-ART does not learn directly from the textual features. Instead, it identifies key tags by learning the probabilistic distribution of tag occurrences. More importantly, GHF-ART incorporates an adaptive method for effective fusion of multi-modal features, which weights the features of multiple data sources by incrementally measuring the importance of feature modalities through the intra-cluster scatters. Extensive experiments on two web image data sets and one text document set have shown that GHF-ART achieves significantly better clustering performance and is much faster than many existing state-of-the-art algorithms.
New Approach for Detecting Leakage of Internal Information; Using Emotional Recognition Technology (2015)

Currently, the leakage of internal information has emerged as one of the most significant security concerns in enterprise computing environments. Especially, damage due to internal information leakage by insiders is more serious than that by outsiders because insiders have considerable knowledge of the system's identification and password (ID&P/W), the security system, and the main location of sensitive data. Therefore, many security companies are developing internal data leakage prevention techniques such as data leakage protection (DLP), digital right management (DRM), and system access control, etc. However, these techniques cannot effectively block the leakage of internal information by insiders who have a legitimate access authorization. The security system does not easily detect cases which a legitimate insider changes, deletes, and leaks data stored on the server. Therefore, we focused on the insider as the detection target to address this security weakness. In other words, we switched the detection target from objects (internal information) to subjects (insiders). We concentrated on biometrics signals change when an insider conducts abnormal behavior. When insiders attempt to leak internal information, they appear to display abnormal emotional conditions due to tension, agitation, and anxiety, etc. These conditions can be detected by the changes of biometrics signals such as pulse, temperature, and skin conductivity, etc. We carried out experiments in two ways in order to verify the effectiveness of the emotional recognition technology based on biometrics signals. We analyzed the possibility of internal information leakage detection using an emotional recognition technology based on biometrics signals through experiments.
High precision time synchronization scheme for Distributed Intrusion Detection System (2010)

Time synchronization is an important middleware service of distributed systems, amongst which Distributed Intrusion Detection System (DIDS) makes extensive use of time synchronization in particular. Time synchronization has become a critical area of research today. Network Time Protocol (NTP) and Precision Time Protocol (PTP) are the current widely accepted standards for synchronizing clock over. This paper makes a comparison on the merits and the shortcomings of the two protocols and then provides a scheme of time synchronization based on NTP. This scheme uses a new approach to get local clock, which improves the accuracy of local clock. The results of experiments approve the scheme is feasible and improves the synchronization precision.
Microinjection into Zebrafish Embryos (2003)

Microinjection remains the most popular and effective of the methods to introduce DNA, RNA, and proteins into fertilized zebrafish eggs. The method is simple and reliable. A microinjection pipet is filled with the DNA or RNA solution and attached to an apparatus that forces the solution out of the pipet with air pressure. A small amount of solution is then expelled into the cytoplasm of the embryo before withdrawing the pipet, and the injected embryos are incubated to develop further. Once inside the cells, the foreign DNA or RNA is transcribed and/or translated within the developing embryos and the functional roles of their protein products can be evaluated by morphological, physiological or molecular changes. Thus, microinjection has been widely used for generating transgenic fish (, , ), analyzing gene function by overexpression of DNA or RNA (, , ) and mapping cell fate in early blastula embryos (,).
Characterization of Chemical Pulp Fines (2006)

This study presents a number of new methods for characterizing chemical pulp fines. The methods are used to measure the dewatering rate, settling rate, and viscosity of a fines suspension, which are closely related to the specific surface area of fines. The dewatering rate of the fines suspension measured with a gravimetric water retention meter that used pressure filtration coincided with the results obtained with a conventional method for measuring the drainage time in a sheet mold. The settling rate measured with a Turbiscan device, which is equipped with an optical head for scanning the sample automatically, correlated with the results of conventional visual observation. The Brookfield viscosity of the fines suspension may be dependent on the degree of hydration of the fines network. All of these new methods were found to be simple, fast, and accurate for measurement.The finer the fines fractions, the more it contributed to slowing down the settling and increasing the viscosity of the fines suspension.
Expression Vectors for Human-mouse Chimeric Antibodies (2005)

The production of recombinant antibodies has been generally recognized as time-consuming and labor-intensive. The aim of our study is to construct mammalian expression vectors containing the cDNA encoding the human constant regions and murine variable regions to massively and cost-effectively produce full-length chimeric antibodies. Unique restriction sites flanking the Ig variable region were designed to allow for the replacement of variable regions generated by PCR. Western blot analysis of the chimeric antibodies revealed that the expressed products were of the predicted size, structure and specificity. The usefulness of the vectors was confirmed by construction of human-mouse chimeric antibody-HCAb which secretes murine antibody against the human colorectal cancer. Selected in medium containing gradually increasing methotrexate (MTX), clones with increased expression of the product gene can be efficiently generated. The secretion of recombinant chimeric antibody-HCAb yielded 30 pg cell(-1) day(-1) at 10(-6 )M MTX. With this high-level expression from pools, the convenient and rapid production of over 100 milligram amounts per liter of recombinant antibodies may be achieved, which indicates the significant roles of pYR-GCEVH and pYR-GCEVL in the production of chimeric antibodies.
Intrahepatic Veno-Occlusive Disease in Cirrhosis with Chronic Ascites* (1963)

From the Departments of Surgery, Gastroenterology, Pediatric Cardiology and the Cardiology Laboratory, The Cleveland Clinic Foundation, Cleveland, Ohio **Present address: College of Physicians and Surgeons, Columbia University, 622 W. 168 St., New York, N. Y.
Targeting the C-type Lectins-Mediated Host-Pathogen Interactions with Dextran (2014)

Dextran, the α-1,6-linked glucose polymer widely used in biology and medicine, promises new applications. Linear dextran applied as a blood plasma substitute demonstrates a high rate of biocompatibility. Dextran is present in foods, drugs, and vaccines and in most cases is applied as a biologically inert substance. In this review we analyze dextran's cellular uptake principles, receptor specificity and, therefore, its ability to interfere with pathogen-lectin interactions: a promising basis for new antimicrobial strategies. Dextran-binding receptors in humans include the DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) family receptors: DC-SIGN (CD209) and L-SIGN (the liver and lymphatic endothelium homologue of DC-SIGN), the mannose receptor (CD206), and langerin. These receptors take part in the uptake of pathogens by dendritic cells and macrophages and may also participate in the modulation of immune responses, mostly shown to be beneficial for pathogens per se rather than host(s). It is logical to predict that owing to receptor-specific interactions, dextran or its derivatives can interfere with these immune responses and improve infection outcome. Recent data support this hypothesis. We consider dextran a promising molecule for the development of lectin-glycan interaction-blocking molecules (such as DC-SIGN inhibitors) that could be applied in the treatment of diseases including tuberculosis, influenza, hepatitis B and C, human immunodeficiency virus infection and AIDS, etc. Dextran derivatives indeed change the pathology of infections dependent on DC-SIGN and mannose receptors. Complete knowledge of specific dextran-lectin interactions may also be important for development of future dextran applications in biological research and medicine.
Recall of Injury Events by Thirteen Year Olds (1989)

The level of under-reporting of injury events which resulted in medical treatment was determined for a group of 631 thirteen-year olds. Two-year recall data was compared with the medical records of an accident and emergency department. Thirty-nine percent of all visits to the accident and emergency department were not recalled. Recall was shown to be related to the number of injury events, time elapsed since an injury event, type and severity of injury but not to whether the victim was hospitalized. Logistic regression analysis suggested that the recall of injury events depended on the type of injury sustained, time elapsed since the injury event, the number of injury events, and an interaction effect between the time and the number of injuries.
Is it 'too bloody late'? Older people's attitudes to the National Physical Activity Guidelines (2006)

The National Physical Activity Guidelines (NPAGs) are the evidencebased recommendations on physical activity for all Australians. This study examines the attitudes of older people to the NPAGs with the aim of identifying communication objectives for social marketing practitioners when designing messages about physical activity specifically targeted at older people. Eight focus groups were conducted at the Positive Ageing Foundation’s conference rooms in Perth, Western Australia, with between six and eight participants in each. None of the participants had previously seen the NPAGs but some of the content had filtered through in the media. Of most concern was that some participants felt that it was already too late for older people to become more physically active. Participants were receptive to a holistic approach including social interaction and mental stimulation for overall health and well-being, but males in particular were cynical towards the source of social marketing messages. The findings suggest that social marketers targeting older people with physical activity need to address three key communication objectives: 1) the benefits of ‘incidental’ physical activity; 2) that short bouts of moderate-intensity physical activity can be accumulated throughout the day to total the recommended thirty minutes; and 3) it’s never too late to benefit from being more physically active.
Conducting a multiparty multimedia session over ATM: using hierarchically encoded data (2002)

Heterogeneous multicast (HMC) is a communication paradigm for distributing real-time streams among multiple session participants that have different constraints and reception preferences. In HMC, sources offer streams to the participants, and each participant specifies individualized fidelity level for each stream he/she wants to receive. Participants can change their specification in mid-session. The approach is based on sources encoding streams in layers which can be individually ordered. The network provides transport that allows ordering and selective distribution of individual layers. ATM infrastructure is used for connection-based transport and cell switching. However, ATM signalling is enhanced to enable the establishment and management of multipoint, multi-VC connections for carrying multiple layers. The ATM-based network module also supports admission control, and QOS-based multipoint routes.
On Calculating the Optical Constants from Reflection Coefficients (1939)

Get PDF Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text Richard Tousey, "On Calculating the Optical Constants from Reflection Coefficients," J. Opt. Soc. Am. 29, 235-239 (1939) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Synthesis of Diaryl Ethers, Diaryl Sulfides, Heteroaryl Ethers and Heteroaryl Sulfides under Microwave Dielectric Heating (2005)

This paper describes the synthesis of diaryl ethers and sulfides by utilizing microwave heating methodology. The methodology is shown to be rapid and efficient for the coupling of phenols or thiophenol with electron-deficient aryl halides through a SNAr reaction. The scope of the protocol can be expanded to six-membered heterocycles bearing a hydroxyl group as well as to the reaction of 2-pyrimidinethiol with mildly activated aryl halides, providing heteroaryl ethers and sulfides, respectively. The advantages of the present method include the wide substrate scope, the obviation of metal catalysts, ease of product isolation, and high purity of products.
A Prospective, Controlled Assessment of Factors Influencing Acceptance of Screening Colonoscopy (2002)

Colon cancer screening behavior seems to be associated with having a regular primary physician, as well as other cancer screening behaviors. Knowledge of colon cancer is the most reliable discriminator of prior screening status. There does not seem to be any difference in the preferences expressed by never-screened and screened patients with respect to the aspects of colonoscopy that they find objectionable.
Survival of the fittest (1995)

Multimedia is an art-world term, often credited to designers Charles and Ray Eames, that describes the fusion of media such as painting, sculpture, photography, music, and video. Within the world of computers it is used broadly to describe almost any combination of media, ranging from simple text and graphics through to the Eames ’ vision [Preece et al. 1994; Shneiderman 1992]. This diversity raises questions about the origins of multimedia interface styles, emerging genres, and widgets. In the natural world such diversity is elegantly explained by Darwin’s theory of evolution through survival of the fittest. In the case of technology, market forces determine which novel designs survive. Predicting change is hard but we now know much about the preferences and limitations of humans interacting with computers. Principles can be drawn upon that help explain why some interfaces survive and others become extinct. For example, interfaces that are predictable and consistent, allow users to undo their actions easily, protect against errors, and provide help at the right time tend to survive (see e.g., Nielsen [1995]). We identify seven multimedia eras:
Minimax design of hybrid multirate filter banks (2002)

Studied in this paper are hybrid multirate filter banks which consist of analog analysis filters, slow A/D converters, digital expanders, and digital synthesis filters. The synthesis filters are designed to minimize the maximum energy gain of the error system, suitably weighted, between the filter bank and a fast A/D converter with some time delay. This hybrid and multirate problem is reduced to one of H/sub /spl infin// optimization involving only linear time-invariant, discrete-time systems, which is then solvable. An example is discussed and studied to illustrate aspects in the design process.
A Generic Approach for Planar Patches Stereo Reconstruction (1995)

: Whereas edge-based stereo has traditionally received a lot of attention, relatively few explicit region-based 3D reconstruction techniques have been developed, despite the significant advantages such global features present for representing indoor or urban environments. We propose a general framework for 3D reconstruction of planar patches from stereoscopic pairs of images, and explicit a generic planar equation recovery scheme, which can then be applied to several types of stereosystem geometry. Another advantage of the formulation is its possible use on various cues: we propose three different applications, using moments of inertia, parametric and non-parametric photometric analysis. In each case, the robustness of the results is assessed, both with analytic data consistency check and tests performed on synthetic stereograms. Experiments on real data are also presented.
A Computer-Operated Following Ellipsometer (1967)

This paper describes the construction and performance of a computer-operated following ellipsometer. By modifying a conventional ellipsometer and operating it with a process control computer, the polarizer and analyzer null positions can he located in about one second with a resolution of 0.01 degrees . This instrument has been used successfully for in situ studies of the buildup and removal of thin anodic oxide films. As the growth of a film is monitored, the computer also plots the null positions of an X-Y recorder and stores all the experimental data for later printing, punching on cards, or replotting along with theoretical curves.
Interstitial Precast Prestressed Concrete Trusses for Ciba-Geigy Life Science Building (1992)

Architectural precast concrete and structural precast, prestressed concrete combine effectively to frame the new $126 million, three-story, Ciba-Geigy Life Science Building in Summit, New Jersey. A major feature of the building is the use of interstitial pretensioned Vierendeel trusses which permit large column-free spaces and thus much needed flexibility in the layout of floors. The result is a cost-effective, totally prefabricated building which is functional and attractive. The purpose of this article is to present the design concept and structural features of the system, and to describe the production, handling and erection highlights of the precast concrete elements.
Music organisation using colour synaesthesia (2007)

The movement of music from physical discs to digital resources managed on a computer has had an effect on the listening habits of users. We explore using the potential of the innate synaesthesia that some people report feeling between colour and mood in a novel interface that enables a user to explore their music collection and create musical playlists in a more relevant way.