gebhart/patrepeval huggingface dataset:
A Case of Disseminated Infection with Skin Manifestation due to Non-<i>neoformans</i> and Non-<i>gattii</i><i>Cryptococcus</i> in a Patient with Refractory Acute Myeloid Leukemia (2017)

Cryptococcus spp. other than Cryptococcus neoformans or Cryptococcus gattii were previously considered saprophytes and thought to be non-pathogenic to humans. However, opportunistic infections associated with non-neoformans and non-gattii species, such as Cryptococcus laurentii and Cryptococcus albidus, have increased over the past four decades. We experienced a case of cryptococcosis caused by non-neoformans and non-gattii spp. in a 47-year-old female with refractory acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation. The patient underwent salvage chemotherapy with fluconazole prophylaxis and subsequently developed neutropenic fever with multiple erythematous umbilicated papules. A skin biopsy revealed fungal hyphae and repetitive blood cultures showed yeast microorganisms that were identified later as C. laurentii by Vitek-II . Skin lesions and fever began to improve with conventional amphotericin B therapy. The treatment regimen was continued for 21 days until the disseminated cryptococcosis was completely controlled.
Investigation of the grid method for accurate in-plane strain measurement (2009)

[Departement_IRSTEA]Ecotechnologies [TR1_IRSTEA]MOTIVE
Direct neurophysiological evidence for spatial suppression surrounding the focus of attention in vision (2006)

The spatial focus of attention has traditionally been envisioned as a simple spatial gradient of enhanced activity that falls off monotonically with increasing distance. Here, we show with high-density magnetoencephalographic recordings in human observers that the focus of attention is not a simple monotonic gradient but instead contains an excitatory peak surrounded by a narrow inhibitory region. To demonstrate this center-surround profile, we asked subjects to focus attention onto a color pop-out target and then presented probe stimuli at various distances from the target. We observed that the electromagnetic response to the probe was enhanced when the probe was presented at the location of the target, but the probe response was suppressed in a narrow zone surrounding the target and then recovered at more distant locations. Withdrawing attention from the pop-out target by engaging observers in a demanding foveal task eliminated this pattern, confirming a truly attention-driven effect. These results indicate that neural enhancement and suppression coexist in a spatially structured manner that is optimal to attenuate the most deleterious noise during visual object identification.
Anti‐interleukin‐6 signalling therapy rebalances the disrupted cytokine production of B cells from patients with active rheumatoid arthritis (2017)

Rheumatoid arthritis (RA) is associated with abnormal B cell-functions implicating antibody-dependent and -independent mechanisms. B cells have emerged as important cytokine-producing cells, and cytokines are well-known drivers of RA pathogenesis. To identify novel cytokine-mediated B-cell functions in RA, we comprehensively analysed the capacity of B cells from RA patients with an inadequate response to disease modifying anti-rheumatic drugs to produce cytokines in comparison with healthy donors (HD). RA B cells displayed a constitutively higher production of the pathogenic factors interleukin (IL)-8 and Gro-α, while their production of several cytokines upon activation via the B cell receptor for antigen (BCR) was broadly suppressed, including a loss of the expression of the protective factor TRAIL, compared to HD B cells. These defects were partly erased after treatment with the IL-6-signalling inhibitor tocilizumab, indicating that abnormal IL-6 signalling contributed to these abnormalities. Noteworthy, the clinical response of individual patients to tocilizumab therapy could be predicted using the amounts of MIP-1β and β-NGF produced by these patients' B cells before treatment. Taken together, our study highlights hitherto unknown abnormal B-cell functions in RA patients, which are related to the unbalanced cytokine network, and are potentially relevant for RA pathogenesis and treatment.
Randomized study of continuous infusion fluorouracil versus fluorouracil plus cisplatin in patients with metastatic colorectal cancer. (1990)

One hundred twenty-two chemotherapy-naive patients with histologically confirmed colorectal adenocarcinoma were entered into a randomized trial comparing infusional fluorouracil (FU) versus cisplatin (CDDP) and FU. In both groups, patients received continuous infusion FU 1,000 mg/m2/d for 5 consecutive days every 4 weeks. Patients randomized to CDDP/FU also received CDDP 20 mg/m2 intravenous (IV) bolus on days 1 to 5 of each cycle. Patients were comparable in terms of age, performance status, baseline laboratory values, dominant sites of measurable disease, and percent of liver involvement. The partial response rate was significantly greater in patients who received CDDP/FU versus FU alone (25% v 3%, P = .001). Patients who received CDDP/FU experienced significantly greater toxicity compared with FU alone: grades 3 and 4 hematologic toxicity occurred in 22% and 0% of patients, respectively (P = .0001); grades 2 to 4 nausea and vomiting occurred in 80% and 15% of patients, respectively (P = .0001). There were no significant differences in either the duration of response (median, 6 and 4.7 months for CDDP/FU and FU groups, respectively) or survival (median 10, and 12 months, respectively). Compared with infusional FU alone, CDDP/FU provided a significantly greater partial response rate with increased toxicity, but it did not improve overall survival in patients with advanced colorectal carcinoma. Therefore, the use of CDDP/FU as routine therapy for the treatment of colorectal carcinoma cannot be recommended.
Organoboranes. 20. The facile allylboration of representative carbonyl compounds with B-allyl derivatives of 9-borabicyclo[3.3.1]nonane (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganoboranes. 20. The facile allylboration of representative carbonyl compounds with B-allyl derivatives of 9-borabicyclo[3.3.1]nonaneGary W. Kramer and Herbert C. BrownCite this: J. Org. Chem. 1977, 42, 13, 2292–2299Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/jo00433a022https://doi.org/10.1021/jo00433a022research-articleACS PublicationsRequest reuse permissionsArticle Views591Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chelate and Pincer Carbene Complexes (2006)

This chapter contains sections titled: Introduction Design Strategy Bite Angle Tripod Ligands Synthetic Strategies Failure to Chelate Ligand Properties Types of Ligand C,C Chelates N,C Chelates and Pincers P,C Chelates and Pincers Catalysis Medicinal Applications Conclusions References
Hydrogels for water filters: Preparation and antibacterial evaluation (2011)

Abstract Acrylic acid was crosslinked with N , N ′‐methylenebisacrylamide and converted to bioactive hydrogels by neutralization with different amino containing compounds. Several amino containing compounds were used such as 2‐aminopyridine, triethanol amine, hexamethylenetetramine (HMTA), pyridine, and imidazole. The best crosslinker ratio was determined in addition to the maximum absorbed water in different mediums. The antibacterial activity of the prepared gels were examined against examples of Gram‐positive ( Staphylococcus aureus ) and Gram‐negative bacteria ( Escherichia coli ) using agar plate method. The study was extended by evaluating one of prepared gels in columns as models for water filters. All prepared gels showed antibacterial action in agar plate method against both bacterium and the column method using one of the prepared gels showed excellent filtration and biocidal action. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
A Method of Recognition and Representation of Korean Characters by Tree Grammars (1979)

A syntactic method is applied to the recognition of Korean characters (Hangul). Since they develop into complex characters by the sequential addition of fundamental characters under positioning rules, there are a large amount of characters and consequently there exist many similar characters. Therefore, the sequential extraction, according to the positioning rules, of fundamental characters composing Korean characters is effective for automatic recognition. As a structural analysis, a production process of fundamental characters is represented by tree grammars, and the extraction algorithm of fundamental characters and the results of computer simulation are described.
A portable surface plasmon resonance biosensor capable of phase interrogation in a large dynamic range (2014)

With the development of a point of care (POC) biosensor in mind, a polymer-molding prism with double parabolic surfaces is invented and developed to implement an ultra-compact SPR biosensor with extremely high sensitivity. The polymer molded parabolic prism is cost effective and disposable, thus cross contamination between biological samples can be avoided. A highly sensitive biosensor with a form factor less than 15cm*15cm*5cm was received with a tunable excitation angle of light beam for a large dynamic range. A highly sensitive optical phase interrogation was demonstrated. The biosensor is also compatible to a modern microscopy platform.
Polymerase Chain Reaction Identification of Three Members of the<i>Anopheles sundaicus</i>(Diptera: Culicidae) Complex, Malaria Vectors in Southeast Asia (2007)

Anopheles sundaicus s.l., a major malaria vector taxon, occurs primarily along coastal areas and on islands in Southeast Asia. Our previous studies using cytochrome oxidase I, cytochrome-b, and internal transcribed spacer 2 markers discriminated three allopatric species: An. sundaicus s.s. in northern Borneo, An. epiroticus in Southeast Asia, and An. sundaicus E on Sumatra and Java, Indonesia. Morphological comparisons of three developmental stages did not reveal unique diagnostic characters that could reliably distinguish the three species. Therefore, we developed a multiplex polymerase chain reaction (PCR) assay based on two mitochondrial DNA markers to unambiguously identify them. This PCR was tested on 374 specimens from 24 different geographical populations, expanding our knowledge of the distribution of these species.
Syntheses and Crystal Structures of Novel Di- and Trinuclear Rhodium Complexes Bridged by Pyrazine (2001)

Abstract Novel di- and trinuclear Rh complexes, [Rh2(PPh3)4(H)4(Me2CO)2(µ-pyz)](ClO4)2·EtOH and [Rh3(PPh3)6(µ-pyz)3](ClO4)3·EtOH were selectively isolated from the reaction of [Rh(PPh3)2(H)2(Me2CO)(EtOH)]ClO4 with pyrazine (pyz) in Me2CO and THF, respectively. Their structures were crystallographically characterized.
Human Modeling – From Bubblemen to Skeletons (2001)

<div class="htmlview paragraph">This paper introduces a novel human modeling system utilizing the ADAMS (Mechanical Dynamics Inc.) multi-body simulation program. The FIGURE Human Modeling system is a plug-in to ADAMS, which provides users with the capability to generate human models of various levels of detail and fidelity, permitting simulations ranging from passive response (crash, falls, etc.) to active participation (sports performance, task simulation).</div> <div class="htmlview paragraph">One of the major innovations of FIGURE is how human motion is simulated using a concept of “motion agents”. Motion agents are parts, which are positioned on the body segments at the location of the motion target marker from the motion, capture system. The motion agent is attached to the body part with a 6 degree-of-freedom spring so as to be a “motion influencer” rather than a “motion governor”. Data from the motion capture system drives the agents thereby driving the human model. Since the human model is physics-based, the model will not violate joint restrictions, environment contacts, etc. From this simulation, resulting muscle elongation histories are then captured. A second simulation is performed using these muscle elongation histories via proportional derivative (PD) controllers to drive the human model using a direct dynamics approach.</div> <div class="htmlview paragraph">The paper introduces the modeling paradigm of FIGURE and provides an example of direct dynamics simulation based on data from a newly introduced motion capture device.</div>
[A new method of gait analysis in Duchenne muscular dystrophy]. (1992)

We assessed gait in Duchenne muscular dystrophy (DMD) mainly by determining alteration of foot pressure using a new gait analyzing procedure. DMD patients showed a characteristic foot pressure pattern according to their degree of dysfunction. In stage I disease, the observed pattern was the same as that of normal controls. In stage II, the period during which the center of foot pressure was seen in the front part of the foot was prolonged. This change became more marked in stage III. In stage IV, the center of foot pressure began at the head of the ossis metatarsalis primi and moved back and toward the lateral side. Thereafter, the center of foot pressure again moved forward along the outside of the foot. These changes were considered to be the result of talipes equinus and waddling gait, which are commonly demonstrated in patients with DMD.
Analyse et validation d'un modèle de comportement directionnel des outils de forage monoblocs PDC (2001)

La prediction du comportement directionnel d'un systeme de forage necessite d'etablir un modele de comportement directionnel de l'outil de forage. Par une approche cinematique et sur la base d'une simplification de la structure de coupe de l'outil, le modele elabore aboutit a une loi reliant les efforts moyens exerces sur l'outil au deplacement de ce dernier. Chaque partie de l'outil, a savoir, la structure de coupe, la garde active et la garde passive, a une influence distincte sur le comportement directionnel en terme d'angle de Walk et de forabilite laterale. Les essais effectues au laboratoire valident les predictions du modele theorique developpe. La tendance de walk de l'outil peut etre alors oBbtenue a partir de simples criteres geometriques decrivant le profil de l'outil. Le modele d'interaction outil-roche developpe couple avec un code de calcul 3D du comportement mecanique de la garniture devrait deboucher sur un outil performant pour la prediction de l'inclinaison et de l'azimut des trajectoires de forage.
Hot particulate removal and desulfurization results from the METC integrated gasification and hot gas cleanup facility (1995)

The Morgantown Energy Technology Center (METC) is conducting experimental testing using a 10-inch diameter fluid-bed gasifier (FBG) and modular hot gas cleanup rig (MGCR) to develop advanced methods for removing contaminants in hot coal gasifier gas streams for commercial development of integrated gasification combined-cycle (IGCC) power systems. The program focus is on hot gas particulate removal and desulfurization technologies that match the temperatures and pressures of the gasifier, cleanup system, and power generator. The purpose of this poster is to present the program objectives and results of the work conducted in cooperation with industrial users and vendors to meet the vision for IGCC of reducing the capital cost per kilowatt to $1050 and increasing the plant efficiency to 52% by the year 2010.
Response to clarifying the costs of conflicts of interest (2015)

Linked Comment: Citrome et al. Int J Clin Pract 2015; 69: 267–8. Linked Comment: Clark et al. Int J Clin Pract 2015; 69: 270–2. Linked Comment: Mayes et al. Int J Clin Pract 2015; 69: 384–5.
A Scalar Representation of Electromagnetic Fields (1953)

It is shown that in a region which is free of currents and charges, any electromagnetic field may be rigorously derived from a single, generally complex, scalar wave function V(x, t). In terms of this function the momentum density g(x, t) and the energy density w(x, t) of the field may be defined in such a way that they are represented by expressions analogous to the formulae for the probability current and the probability density in quantum mechanics; in a homogeneous isotropic medium
Inhibition of the Local Inflammatory Response in Man by Antimetabolites (1966)

Abstract The effects of chemotherapy on the local inflammatory response in man were studied in 33 patients. Inhibition of the mononuclear cell phase of the response at 4, 8 and 24 hours was noted. The median on-therapy values at these hours were 0, 8.5 and 23 per cent compared to control values of 4, 24.5 and 86 per cent, respectively. The 24-hour values for the individual types of therapy were 13.5 per cent for intensive combination therapy with 4 antitumor agents, 21 per cent for 6-mercaptopurine given i.v. daily for 5 days, 2 per cent for methotrexate given i.v. daily for 5 days, 37 per cent for intermittent methotrexate and 56 per cent for other therapy. Recovery was substantial within 5 days of the end of therapy. The inhibition was not correlated with alterations in the levels of circulating granulocytes or lymphocytes, nor with the numbers of granulocytes entering the inflammatory site. Complicating infections were noted in eight patients, seven of whom were in the most strongly inhibited group. Observations of the response in ten untreated patients with acute leukemia showed both impaired granulocyte and mononuclear phases of the response.
HVACSIM+ building systems and equipment simulation program : (1986)

A nonproprietary building-system simulation program called HVACSIM+, which stands for HVAC SIMulation PLUS other systems, was developed at the National Bureau of Standards (NBS) in an effort to understand the dynamic interactions between a building shell, an HVAC system, and building controls. HVACSIM+ consists of a main simulation program, a library of HVAC system component models, a building shell model, and interactive front end input-data-generation programs. The report presents the overall architecture of the HVACSIM+ program, algorithms used in the main simulation program, a brief discussion of the numerical methods used in solving a system of nonlinear simultaneous equations, integrating stiff ordinary differential equations and interpolating data and descriptions of the building shell and zone models.
Impedance Tuning Unit for DVB-H Front-End (2006)

When implementing low frequency antennas in small devices, e.g., mobile phones using DVB-H, a large mismatch is inevitable. If a impedance tuning unit is introduced reflection losses and noise are reduced while gain is improved. A ITU consisting of 6 switched capacitances and 2 fixed LTCC inductors is studied. Simulations show that since a VSWR = 10 mismatch is reduced to better than VSWR = 2, the ITU increases the power delivered by 2.9 dB to 4.2 dB for an antenna mismatch between VSWR = 4 and VSWR = 8. In the same time, the average noise figure for VSWR = 4 is reduced by 1.4 dB from 4.6 dB to 3.2 dB; and for VSWR = 8 it is reduced by 2.8 dB from 6.4 dB to 3.7 dB. The highest noise figure for VSWR = 8 is reduced by 4.2 dB from 9.1 dB to 4.9 dB.
THERMAL DECOMPOSITION OF PLUTONIUM(IV) OXALATE AND HYDROFLUORINATION OF PLUTONIUM(IV) OXALATE AND OXIDE (1956)

Hydrogen peroxide has been used to reduce plutonium (VI) in nitric acid solution to the (IV) valence state. However, reduction of plutonium (VI) solutions containing iron has often been incomplete when hydrogen peroxide was used as the reducing agent. Since reduction of plutonium (VI) has been applied in plant solutions containing iron, a study of the plutonium (VI) reduction with hydrogen peroxide was undertaken. Variables tested included plutonium, nitric acid, and iron concentrations.
Activity and Stability Trends for Oxygen Evolution Reaction Electrocatalysts (2013)

Abstract not Available.
Accounting for the effects of non-ideal minor structures on the optical properties of black carbon aerosols (2018)

Abstract. Black carbon (BC) aerosol is the strongest sunlight-absorbing aerosol, and its optical properties are fundamental to radiative forcing estimations and retrievals of its size and concentration. During incomplete combustion, BC particles exist as aggregate structures with small monomers, which are widely represented by the idealized fractal aggregate model formed by monodisperse spherical monomers in point-contact. In reality, BC particles possess complex and non-ideal minor structures besides the overall aggregate structure, altering its optical properties in unforeseen ways. This study introduces a parameter volume variation to quantify and unify different minor structures, and develops an empirical relation to account for their effects on BC optical properties from those of ideal aggregates. Minor structures considered are the polydispersity of monomer size, irregularity and coating of individual monomer, and necking and overlapping among monomers. The discrete dipole approximation is used to calculate the optical properties of aggregates with these minor structures. Minor structures result in scattering cross section enhancement slightly more than that of absorption cross section, and their effects become weaker with the increase of wavelength. Their effects on the angular-dependent phase matrix as well as asymmetry factor are negligible. Our results suggest that a correction ratio of 1.05 is necessary to account for the mass/volume normalized absorption and scattering of non-ideal aggregates in comparison to ideal ones. In other words, minor structures tend to enhance the BC mass absorption and scattering by 5 %, which also applies to aggregates with multiple minor structures. The simulations of optical properties of non-ideal aggregates are greatly simplified, because they can be directly obtained from those of the corresponding ideal aggregates. We expect this generalized correction to find wide use for modeling realistic BC aggregates due to the simplicity involved in generating ideal fractal aggregates, and it is of great value for not only interpretation of measurements but also practical modeling that requires large amount of simulations.