gebhart/patrepeval huggingface dataset:
Third-order optical susceptibility in short-period GaAs doping superlattices (1989)

We propose that short-period doping superlattices are suitable for the enhancement of a third-order susceptibility arising from free carriers in nonparabolic energy subbands. The inherent advantage lies in the ability to simply engineer the superlattice potential profile, yielding control of miniband energy dispersion. We consider short-period GaAs doping superlattices composed of uniformly doped donor and acceptor layers, and planar-doped n- and p-type monolayers separated by intrinsic regions. Calculations of the electronic structure of compensated and n-type noncompensated n-i-p-i superlattices incorporating miniband dispersion at nonzero temperature are reported. We show that small modulations of the superlattice potential lead to large subband nonparabolicities and we calculate a twentyfold improvement in the third-order susceptibility over bulk GaAs at room temperature, comparable to that predicted for GaAs/AlGaAs compositional superlattices.
Generalized Bayesian Model Selection for Speckle on Remote Sensing Images (2018)

Synthetic aperture radar (SAR) and ultrasound (US) are two important active imaging techniques for remote sensing, both of which are subject to speckle noise caused by coherent summation of back-scattered waves and subsequent nonlinear envelope transformations. Estimating the characteristics of this multiplicative noise is crucial to develop denoising methods and to improve statistical inference from remote sensing images. In this paper, reversible jump Markov chain Monte Carlo (RJMCMC) algorithm has been used with a wider interpretation and a recently proposed RJMCMC-based Bayesian approach, trans-space RJMCMC, has been utilized. The proposed method provides an automatic model class selection mechanism for remote sensing images of SAR and US where the model class space consists of popular envelope distribution families. The proposed method estimates the correct distribution family, as well as the shape and the scale parameters, avoiding performing an exhaustive search. For the experimental analysis, different SAR images of urban, forest and agricultural scenes, and two different US images of a human heart have been used. Simulation results show the efficiency of the proposed method in finding statistical models for speckle.
A Polarization Insensitive Frequency Selective Surface for Triband GSM Shielding Applications (2020)

This article reports on a compact, single layer Frequency Selective Surface (FSS) for tri-band GSM shielding applications. The proposed FSS unit cell comprises of three independent elements. The outermost square ring suppresses GSM-900 MHz signals, the innermost annular ring is incorporated in the design to stop GSM-2100 MHz signals and the middle square ring is used to suppress GSM-1800 MHz signals with a -10 dB rejection bandwidth of 600 MHz, 100 MHz, and 250 MHz, respectively. Furthermore, the proposed FSS exhibits a stable frequency response when illuminated by waves at oblique angles of incidence and a polarization insensitive behavior up-to 60°. The proposed FSS unit cell is realized on an FR4 substrate. A finite prototype containing 8 ×7 unit cells with an overall size of 270 ×230 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is also fabricated and tested. A good agreement between the measured and simulated results showed that the proposed FSS can be employed for suppressing unwanted signals in the GSM-900, GSM-1800 and GSM-2100 bands.
Optical Nonlinearities of Guest-Host-Polymer Structures (1988)

Until recently, attempts to take advantage of the large second-order optical nonlinearities of certain conjugated organic molecules in devices were limited to neat crystalline materials, since the requirements for a noncentrosymmetric bulk phase could be met with molecular and polymeric crystals that happen to condense in a noncentrosymmetric point group. [1] The large dipoles that are often observed in these molecules made the growth of optical quality and robust crystals difficult. More recently, mixed systems consisting of the nonlinear optical molecules incorporated into polymer glasses, liquid crystals, and liquid crystal polymers have been investigated. [2] The difficulties in processing that are required to obtain optical quality materials are reduced. For second-order nonlinearities, an alignment process, such as electric field poling, is required to break the center of symmetry inherent in these materials. However, the reduction in number density and alignment attainable with realistic poling fields requires molecules with exceptionally large nonlinear optical susceptibilities in order to obtain bulk materials with nonlinear coefficients large enough to produce sensible devices.
Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators (2016)

Pharmacological modulation of the transient receptor potential melastatin type 8 (TRPM8) is currently under investigation as a new approach for the treatment of pain and other diseases. In this study, a series of N-substituted tryptamines was prepared to explore the structural requirements determining TRPM8 modulation. Using a fluorescence-based screening assay, we identified two compounds acting as an activator (2-(1H-indol-3-yl)-N-(4-phenoxybenzyl)ethanamine, 21) or an inhibitor (N,N-dibenzyl-2-(1H-indol-3-yl)ethanamine, 12) of calcium influx in HEK293 cells. In patch-clamp recordings, compound 21 displayed a significantly higher potency (EC50 = 40 ± 4 μM) and a similar efficacy when compared to menthol; by contrast, compound 12 produced a concentration-dependent inhibition of menthol-induced TRPM8 currents (IC50 = 367 ± 24 nM). Molecular modeling studies using a homology model of a single rat TRPM8 subunit identified a putative binding site located between the VSD and the TRP box, disclosing differences in the binding modes for the agonist and the antagonist.
Novel voltage balancing technique for series connection of IGBTs (2007)

For high power electronics applications, high voltage switches are realised by connecting existing devices in series. The main problem of unequal sharing of voltage across the series connected devices can be minimised by using active gate control techniques, snubber circuits and active clamping circuits. The aim of this paper is to present a novel hybrid voltage balancing technique which can achieve good voltage balancing with minimum number of components and minimum total losses (i.e. IGBT losses and balancing circuit losses). This technique minimises the disadvantages in present voltage balancing techniques and it consists of both an active voltage clamp circuit and an optimised passive snubber. The passive snubber capacitance is optimised to have low power losses. The proposed technique was validated by both simulation and experimental work. In simulation, two lkV/50A IGBTs were connected in series and the results showed good voltage balancing with minimum losses. The experimental work was carried out on three 3.3kV71200A IGBTs connected in series. Experimental results showed good voltage balancing across the devices and the possibility of finding an optimum capacitance. Determining of the optimum snubber capacitance is critical in the hybrid voltage balancing technique and the dependence of the optimum capacitance on load is discussed.
ChemInform Abstract: Design and Synthesis of Ladder‐Shaped Polyethers and Evaluation of the Interaction with Transmembrane Proteins (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
LS14 cells: A model for chemoresistance in liposarcoma (2007)

Liposarcoma, a malignancy of adipose tissue, is the most common soft tissue sarcoma. Patients whose primary tumor cannot be resected or those who have developed metastasis, have poor prognosis since liposarcomas are highly resistant to chemotherapy. We recently generated a spontaneously immortalized cell line, named LS14, from a patient with metastatic liposarcoma. Our goal was to compare the responsiveness of LS14 and SW872 liposarcoma cells to anti-cancer drugs and explore mechanisms of chemoresistance. Using complementary assays for cell viability and number we found that SW872 cells responded robustly to relatively low concentrations of doxorubicin, cisplatin and vinblastine. This reduction in cell viability was due to apoptosis, as evident by phosphatidylserine exposure and caspase 3 cleavage. In contrast, only a high dose of doxorubicin or combination therapy effectively reduced LS14 cell viability and induced apoptosis. LS14 cells showed a higher expression of Bcl-2 and Bcl-xL, but a lower expression of survivin and Bax, than SW872 cells, suggesting that anti-apoptotic proteins contribute to chemoresistance in LS14 cells. Although LS14 cells did not form colonies in soft agar, they generated large tumors and metastases in SCID mice, establishing their tumorigenicity in vivo. In conclusion, LS14 cells are much more resistant to chemotherapy than SW872 cells, making them an excellent model for exploring the efficacy and mechanism of action of anti-cancer drugs in liposarcomas.
Effective Detection of the 2009 H1N1 Influenza Pandemic in U.S. Veterans Affairs Medical Centers Using a National Electronic Biosurveillance System (2010)

VA ESSENCE effectively detected and tracked changing ILI trends during pandemic H1N1 2009 and represents an important temporal alerting system for monitoring health events in VA facilities.
A Study of Fast Similarity Search Techniques in Metric Spaces (2011)

報告番号: 甲27286 ; 学位授与年月日: 2011-03-24 ; 学位の種別: 課程博士 ; 学位の種類: 博士(情報理工学) ; 学位記番号: 博情第324号 ; 研究科・専攻: 情報理工学系研究科電子情報学専攻 ; 審査委員：東京大学教授　喜連川優(主査),東京大学教授　安達淳,東京大学教授　石塚満,東京大学教授　森川博之,東京大学准教授　田浦健次朗,東京大学准教授　豊田正史
Why T Cells of Thymic Versus Extrathymic Origin Are Functionally Different (2008)

Age-related thymic involution severely impairs immune responsiveness. Strategies to generate T cells extrathymically are therefore being explored with intense interest. We have demonstrated that T cells produced extrathymically were functionally deficient relative to thymus-derived T cells. The main limitation of extrathymic T cells is their undue susceptibility to apoptosis; they thus do not expand properly when confronted with pathogens. Using oncostatin M-transgenic mice, we found that in the absence of lymphopenia, T cells of extrathymic origin constitutively undergo excessive homeostatic proliferation that leads to overproduction of IL-2 and IFN-gamma. IFN-gamma up-regulates Fas and FasL on extrathymic CD8 T cells, thereby leading to their demise by Fas-mediated apoptosis. Moreover, IFN-gamma and probably IL-2 curtail survival of extrathymic CD4 T cells by down-regulating IL-7Ralpha and Bcl-2, and they support a dramatic accumulation of FoxP3(+) T regulatory cells. Additionally, we show that wild-type thymus-derived T cells undergoing homeostatic proliferation in a lymphopenic host shared key features of extrathymic T cells. Our work explains how excessive lymphopenia-independent homeostatic proliferation renders extrathymic T cells functionally defective. Based on previous work and data presented herein, we propose that extrathymic T cells undergo constitutive homeostatic proliferation because they are positively selected by lymph node hemopoietic cells rather than by thymic epithelial cells.
A laser anemometer reference for AIR data calibration (2003)

The proposed airborne laser velocimeter ALEV-3 is discussed. The instrument is intended to be able to solve a large number of reference problems for air data, angle of attack, and sideslip measurement during aircraft flight tests. The use of this type of instrument is expected to reduce the time and cost of this phase of new aircraft programs. After a brief summary of calibrated tool requirements, the prototype equipment is described together with its applicability for flight tests.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Deformation Modes in Stainless Steel During Laser Shock Peening (2009)

In order to study the deformation mechanisms during ultrahigh strain rate deformation of face centered cubic metals, laser shock peening of a 304L stainless steel is systematically investigated. Two deformation modes—microtwins and microbands—and their interrelationship during high strain rate deformation are discussed in detail. Transmission electron microscopy and selected area electron diffraction are employed to study the deformation modes. It is found that twinning takes place even when the shock pressure is much less than the critical twinning stress in stainless steels. Theoretical critical twinning stress is not the only criteria to decide the deformation modes of twinning or slip. The formation of twinning and slip can be affected by the factors such as loading profile, loading stress/strain rate, stacking fault energy, grain sizes, and cell substructures. Factors that influence twin-slip transition in shock loading are discussed. The formation of dislocation structure is compared with those predicted using 3D dislocation dynamic simulation.
Granulomatous Inflammation of the Vulva and Penis – A Genital Counterpart to Cheilitis Granulomatosa (1979)

3 patients are described, in whom chronic swelling of the external genitals occurred after recurrent infections. The histological findings were identical to those seen in cheilitis granulomatosa, the dermal component of Melkersson-Rosenthal syndrome. The authors suppose that the disease of the 3 patients is a genital counterpart to cheilitis granulomatosa, and the name vulvitis or posthitis granulomatosa is suggested.
EFFECT OF SURFACE NANOCRYSTALLIZATION ONMICROSTRUCTURE AND THERMAL STABILITYOF REDUCED ACTIVATION STEEL (2013)

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Treatment of Severe Sepsis with Artemether-Lumefantrine Is Associated with Decreased Mortality in Ugandan Patients without Malaria (2009)

We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association between the use of artemether-lumefantrine (A-L) and mortality in patients with or without malaria. In patients with negative malaria smears (N = 328 of 379), Kaplan-Meier curves revealed decreased combined inpatient and 30-day mortality among patients receiving A-L versus those who did not (20.6%, SE = 10.6 versus 48.8%, SE = 3.2; Log rank chi(2) = 3.93, P = 0.048). The decrease in mortality associated with A-L was maintained in the most clinically ill patients determined by Karnofsky Performance Scores <or= 50 (16.7%, SE = 15.2 versus 58.3%, SE = 3.7; Log rank chi(2) 3.94, P = 0.041). Research into the properties of A-L is needed to improve treatment of sepsis without compromising malarial susceptibility.
Minimal Aliasing Subband System Identification (2001)

Subband adaptive filters have been proposed to avoid the drawbacks of slow convergence and high computational complexity associated with time domain adaptive filters. While the computational complexity is reduced, other undesired properties, such as signal delays and signal aliasing, are introduced. Aliasing effects may result in loss of perception in speech applications. A method for the design of oversampled filter banks is proposed to reduce these effects. The design method aims at reducing the inband aliasing as well as the reconstruction aliasing for the reason of achieving robustness when weighting in the subbands alters the subband signal phase and magnitude.
Generating compact assertions for control-based logic signals (2011)

This paper presents two approaches for writing compact sets of assertions and for gauging the level of coverage in the assertions. We present a state-table method for writing control-based assertions containing only the necessary Boolean conditions that affect a given control signal. An assertion coverage analyzer was developed to measure the attained assertion coverage based on a set of verification test sequences. Combining both of our methods enables verifiers to measure the quality of their written assertions, which can then be used in formal or dynamic verification. The circuit designs used show that our approach is able to generate additional compact assertions and achieve improved assertion coverage.
Chirp sonar inversion of geoacoustic properties of finely layered seabed (2001)

Chirp sonar reflection amplitude and phase data can be used for real-time inversion of sediment properties such as density, porosity, and sound-speed profiles by assuming homogeneous layering within the seabed [Turgut and Wolf, J. Acoust. Soc. Am. (1996)]. In case of fine layering, inversion results might be erroneous if the chirp pulse does not have enough bandwidth to resolve the layers. An alternative method, based on adjoint-state inversion techniques, is used to estimate sediment impedance fluctuations at wavelength scales. Both methods are tested using real and simulated reflection amplitude data. Simulated reflection amplitude data were obtained by using a poro-viscoacoustic sediment model based on Biot’s theory. Accuracy of the inversion can be improved when both methods are used in a complimentary manner. Limits of these two inversion techniques are also discussed and several recommendations are made to improve the data collection methods. [Work supported by ONR.]
Thiamin‐Diphosphate‐Dependent Enzymes: New Aspects of Asymmetric C—C Bond Formation (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
CARDIOVASCULAR RESPONSES OF 70-79 YEAR OLD MEN AND WOMEN TO ENDURANCE AND STRENGTH TRAINING (1989)

Hagberg, J. M. FACSM; Graves, J. E.; Limacher, M.; Woods, D. R.; Leggett, S.; Cononie, C.; Gruber, J.; Pollock, M. L. FACSM Author Information
ChemInform Abstract: A Ligand Structure‐Enantioselectivity Relationship for the Osmium‐ Catalyzed Asymmetric Dihydroxylation of Olefins. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multiple hormone deficiencies in children with hemochromatosis. (1993)

Patients with thalassemia major require multiple blood transfusions leading to hemochromatosis. These patients often have pubertal delay and growth failure, the etiology of which has not been fully elucidated. We performed an extensive endocrine evaluation which included measurements of spontaneous and stimulated levels of gonadotropins, GH, thyroid hormone, and adrenal hormones in 17 patients between the ages of 12 and 18 yr with hemochromatosis receiving desferoxamine therapy. All of the 17 patients had at least one endocrine abnormality, and 12 had more than one abnormality. Abnormalities of the hypothalamic-pituitary-gonadal axis were the most common. Six patients had clinical evidence of delayed puberty with spontaneous and stimulated gonadotropin and sex steroid levels appropriate for their delayed pubertal stage. All 14 children in puberty LH pulsatility index below the mean for pubertal stage compared to normal children. Six of the 14 had LH pulsatility index more than 2 SD below the mean for pubertal stage. This may be an indicator of abnormal pituitary function. Six patients failed either the provocative GH tests (peak GH < 7 micrograms/L) or had a mean spontaneous GH less than 1 microgram/L. The 4 patients who failed provocative tests had growth velocities more than 2 SD below the mean for bone age. Three patients had evidence of primary hypothyroidism. We conclude that all patients with hemochromatosis need periodic careful endocrine evaluations because the incidence of endocrine dysfunction is substantial and they may benefit from hormonal therapy.
Examination, clarification, and simplification of modal decoupling method for multiconductor transmission lines (1995)

In the application of the modal decoupling method, questions arise as to why the nonnormal matrices LC and CL are diagonalizable. Is the definition of the characteristic impedance matrix Z/sub c/ unique? Is it possible to normalize current and voltage eigenvectors simultaneously, yet assure the correct construction of the Z/sub c/ matrix? Under what conditions do M/sub i//sup t/M/sub u/=I and Z/sub c/=M/sub u/M/sub i//sup -1/? In this paper, these questions are thoroughly addressed. We prove the diagonalizability of matrices LC and CL for lossless transmission lines (though the diagonalizability of their complex analogues, ZY and YZ matrices, is not guaranteed for lossy lines), and demonstrate the properties of their eigenvalues. We have developed an algorithm to decouple one type of matrix differential equation, and to construct the characteristic impedance matrix Z/sub c/ explicitly and efficiently. Based on this work, the congruence and similarity transformations, which have caused considerable confusion and not a few errors in the decoupling and solution of the matrix telegrapher's equations, are analyzed and summarized. In addition, we also demonstrate that under certain conditions, the diagonalization of two or more matrices by means of the congruence or similarity transformations may lead to coordinate system "mismatch" and introduce erroneous results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On-Chip Millimeter Wave Antennas and Transceivers (2015)

The main mechanisms responsible for performance degradation of millimeter wave (mmWave) and terahertz (THz) on-chip antennas are reviewed. Several techniques to improve the performance of the antennas and several high efficiency antenna types are presented. In order to illustrate the effects of the chip topology on the antenna, simulations and measurements of mmWave and THz on-chip antennas are shown. Finally, different transceiver architectures are explored with emphasis on the challenges faced in a wireless multi-core environment.
Multi-layered fuzzy behavior fusion for real-time control of systems with many sensors (2002)

A modular architecture for real-time fuzzy mapping of sensors to control signals is presented. The function is broken down into multiple agents, each of which samples a subset of a large sensor input space. Additional fuzzy agents are employed to fuse the recommendations of the local agents. Real-time implementation without special hardware is possible by using singleton output values during fuzzy rule evaluation. A linguistic syntax for fuzzy systems development is presented, allowing complex nonlinear control functions to be defined using qualitative expressions rather than mathematical terms. Our development tool, PCFUZ, translates this syntax off-line into a data structure for fast execution at run time. Using this system, a fuzzy behavior-based reactive control system has been implemented on an autonomous mobile robot, MARGE, with great success.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>