gebhart/patrepeval huggingface dataset:
Propagation of F-actin disassembly via Myosin15-Mical interactions (2021)

The F-actin cytoskeleton drives cellular form and function. However, how F-actin-based changes occur with spatiotemporal precision and specific directional orientation is poorly understood. Here, we identify that the unconventional class XV myosin [Myosin 15 (Myo15)] physically and functionally interacts with the F-actin disassembly enzyme Mical to spatiotemporally position cellular breakdown and reconstruction. Specifically, while unconventional myosins have been associated with transporting cargo along F-actin to spatially target cytoskeletal assembly, we now find they also target disassembly. Myo15 specifically positions this F-actin disassembly by associating with Mical and using its motor and MyTH4-FERM cargo-transporting functions to broaden Mical's distribution. Myo15's broadening of Mical's distribution also expands and directionally orients Mical-mediated F-actin disassembly and subsequent cellular remodeling, including in response to Semaphorin/Plexin cell surface activation signals. Thus, we identify a mechanism that spatiotemporally propagates F-actin disassembly while also proposing that other F-actin-trafficked-cargo is derailed by this disassembly to directionally orient rebuilding.
Rhodium-Catalyzed Selective Partial Hydrogenation of Alkynes (2015)

The cationic rhodium complex [Rh(PcPr3)2(η6-PhF)]+[B{3,5-(CF3)2C6H3}4]− (PcPr3 = triscyclopropylphosphine, PhF = fluorobenzene) was used as a catalyst for the hydrogenation of the charge-tagged alkyne [Ph3P(CH2)4C2H]+[PF6]−. Pressurized sample infusion electrospray ionization mass spectrometry (PSI-ESI-MS) was used to monitor reaction progress. Experiments revealed that the reaction is first order in catalyst and first order in hydrogen, so under conditions of excess hydrogen the reaction is pseudo-zero order. Alkyne hydrogenation was 40 times faster than alkene hydrogenation. The turnover-limiting step is proposed to be oxidative addition of hydrogen to the alkyne (or alkene)-bound complex. Addition of triethylamine caused a dramatic reduction in rate, suggesting a deprotonation pathway was not operative.
Cell-free varicella-zoster virus in tissue culture (1964)

Infected human thyroid tissue cultures have been found to yield free V-Z virus on ultrasonic disintegration and some virus is also present in the fluid phase of intact tissue cultures, while the yield of virus from infected human amnion cells is very low and no free virus is found in the fluid phase. Thyroid cultures are more susceptible to infection with V-Z virus, and the infected cultures are a better source of complement-fixing antigen, than are amnion cultures. The lack of free virus in infected amnion tissue cultures cannot be attributed to protection by interferon. It also seems likely that if any infectious virus were released it would be more likely to be adsorbed to normal cells than to be inactivated, but as no secondary foci appear in amnion monolayers we conclude that infective virus is not released into the medium. It is suggested that the virus in thyroid cells is present in a more complete form than that in amnion cells. We are grateful to Dr R. M. Rawcliffe of Birkenhead General Hospital and Dr F. Whitwell of Broadgreen Hospital, Liverpool, for arranging the supply of thyroid tissue.
Restless legs, anxiety and caffeinism. (1978)

This clinical study of 62 patients with restless legs syndrome and associated anxious-depressed and other clinical states seems to indicate that caffeine is the major etiological factor in the causation of the restless legs syndrome. Anxiety, while modifying the subjective experience of the dysphoric sensation of restless legs, is not a causative factor. Caffeine is responsible for the increased nervous system arousal as well as for the direct peripheral contractile effect on the striated muscle. This arousal is often reflected psychologically in anxiety and sometimes depressive manifestations, insomnia, heightened proprioceptive awareness and physiologically in the toxic sensory experience of restless legs associated with increased neuromuscular reactivity which may include myoclonus and myokomia.
Effect of Copper Content of Carbon Steel On Corrosion in Sulfuric Acid (1965)

The corrosion rate of carbon steel in 42 percent sulfuric acid solutions has been found to vary considerably between different samples of steel. In an attempt to determine the reason for this variation, an investigation was undertaken in which the effects of chemical composition, microstructure and surface condition of the steel was studied. Results of the investigation indicated that copper content of the steel was the controlling factor determining the corrosion rate. Steels containing 0.02 percent copper had corrosion rates as much as 16 times greater than those of steels containing 0.10 percent copper. Above about 0.10 percent, further increases in copper content up to 0.16 percent did not materially affect corrosion rate. No correlation was found between corrosion rate and any constituent in the steel other than copper. Also, neither condition of the surface nor microstructure of the steel had an appreciable effect on corrosion rate under conditions of the test. Additions of dissolved copper to the test solution appeared to have a slight accelerating effect on corrosion of the steel. Electrochemical measurements indicated that increases in copper content of the steel affected cathodic polarization behavior of the steel in such a way as to reduce the rate of the cathodic reaction in the corrosion process, thereby reducing corrosion rate. It is also possible that copper in the steel has some effect on the anodic reaction; this is being investigated at present.
Packet Classification Using Multi-iteration RFC (2013)

Packet Classification is an enabling technique for the future Internet by classifying incoming packets into forwarding classes to fulfill different service requirements. It is necessary for IP routers to provide network security and differentiated services. Recursive Flow Classification (RFC) is a notable high-speed scheme for packet classification. However, it may incur high memory consumption in generating the pre-computed cross-product tables. In this paper, we propose a new scheme to reduce the memory consumption by partitioning a rule database into several subsets. The rules of each subset are stored in an independent RFC data structure to significantly alleviate overall memory consumption. We also present several refinements for these RFC data structures to significantly improve the search speed. The experimental results show that our scheme dramatically improves the storage performance of RFC.
Key Features of a whole‐school, design approach to literacy teaching in schools (1999)

(1999). Key Features of a whole‐school, design approach to literacy teaching in schools. Australian Journal of Learning Disabilities: Vol. 4, No. 3, pp. 5-11.
Descartes, Other Minds and Impossible Human Bodies (2012)

For nearly a century, skepticism about other minds (SOM) has been a standard problem in epistemology. In recent accounts of social cognition, however, the success of simulation theory and theory-theory have moved philosophical discussion about other minds away from SOM.1 Precedent for this move can be found in an unlikely place, namely in René Descartes’ philosophy, for Descartes so diminished the role of the senses in gaining knowledge that SOM is precluded from becoming a self-standing skeptical challenge. At most, SOM is just one more incarnation of skepticism about the external world. Further, Descartes rejected the natural possibility of a human body existing without a mind. We are all familiar with the real distinction between body and mind, which, at first blush, speaks against this claim, but while a body in general can exist without a mind, a uniquely human body cannot. Descartes indicated all this in a number of places and especially in his correspondence with the Cambridge Platonist Henry More, who asked how we know infants have minds. Descartes replied by citing genetic facts—natural facts—about the origin of a human body which assure us that where we find a human body we necessarily find a human mind. We can therefore reconstruct an answer to SOM on Descartes’ behalf that fundamentally rejects skeptical doubts unique to our knowledge of other minds. And, as a consequence, we can further unsettle the common presumption that the human body is a straightforward object of physical study. To the contrary, it looks to be a unique object that, in its entirety, belongs neither to the metaphysician nor to the physicist.
A Performance Isolation Algorithm for Shared Virtualization Storage System (2009)

It is a challenging task that enables performance isolation while providing performance guarantees among applications that share storage infrastructure. This paper presents admission-control-based proportional allocation (APA), a novel I/O request scheduler that combines the admission control of worst-case resources reserved with the proportional resources allocation to manage the bandwidth resources for performance isolation. APA has three characteristics: 1) admission control for I/O requests of applications; 2) fairness allocation for idle bandwidth resources; 3) performance monitoring and feedback-based weight adjustment. We implemented APA in a prototype performance virtual storage system (PVSS). Through experiments on a real system, we show that APA has ability to provide the performance isolation and predictable performance guarantees, and to avoid the performance interference among virtual disks.
On roundoff error of fixed-point digital filters using sign-magnitude truncation (1972)

This correspondence gives the statistical meansquared error at the output of a digital filter due to roundoff accumulation when fixed-point arithmetic with sign-magnitude truncation is used.
A hydrogen fuelled fast marine transport system (2006)

Hydrogen may offer considerable potential as a marine fuel. The lower fuel mass when compared with existing hydrocarbon fuels can usefully increase payload which in turn benefits the economics of oceanic transport and provides the opportunity to compete in new markets. The potential to virtually eliminate pollution at the point of use may prove significant at a time when exhaust emissions from shipping are becoming a matter of global concern. The potential for hydrogen in the marine environment, the current state of transferable technologies, the particular technical and economic issues that need to be addressed are considered in the context of a design study being conducted on a high speed foil-assisted catamaran capable of transporting 600 industry standard containers at speeds of up to 64 knots (118.5 km/hr) over trans-Pacific and trans-Atlantic trade routes. It is concluded that such a vessel is technically feasible and could achieve door-to-door delivery times as part of an integrated transport chain otherwise only possible by airfreight but at a fraction of the cost.
High Doses of Vitamin B<sub>6</sub> in the Rat Are Associated with Inhibition of Hepatic Tryptophan Metabolism and Increased Uptake of Tryptophan into the Brain (1984)

Acute administration of vitamin B6 to rats (10 mg/kg body weight) led to reduced urinary excretion of N1-methyl nicotinamide and methyl pyridone carboxamide, indicating inhibition of the oxidative metabolism of tryptophan. There was a considerable reduction in the production of 14CO2 from [ring-2-14C]tryptophan, and a significant inhibition of hepatic tryptophan oxygenase when measured in liver homogenates, together with an increase in the concentration of tryptophan in plasma. There was an increase in both the concentration of tryptophan in the brain and the uptake into the brain of peripherally administered [3H]tryptophan, accompanied by a small increase in the rate of synthesis of 5-hydroxytryptamine in the brain. It is suggested that this increase in the uptake of tryptophan into the brain following a relatively large dose of vitamin B6 may explain the beneficial action of the vitamin in some cases of depressive illness.
Synthesis and Ameliorative Effect of Isatin–Mesalamine Conjugates on Acetic Acid‐induced Colitis in Rats (2019)

A series of new isatin–mesalamine conjugates ( 9a – g ) were synthesized via conjugation of isatin ( 3a ) and its derivatives ( 3b – 3d , 4 , 5 , and 6 ) with mesalamine ( 7 ) by using chloroacetyl chloride as a bifunctional linker. Compounds 3a – 3d were prepared by employing Sandmeyer reaction. Compounds 4 , 5 , and 6 were obtained from isatin ( 3a ) via previously reported methods. The synthesized compounds were characterized by IR, mass, 1 H NMR, and 13 C NMR spectral techniques. Synthesized compounds ( 3a – d , 4 , 5 , 6 , and 9a – g ) were evaluated for in vitro antioxidant activity by DPPH assay method using ascorbic acid as standard. Hybrids 9b (IC 50 = 368.6 ± 3.5 μM) and 9f (IC 50 = 335.1 ± 2.9 μM) showed better antioxidant activity than its parent compounds such as 3a (IC 50 = 556.8 ± 2.9 μM), 5 (IC 50 = 511.9 ± 3.6 μM), and 7 (IC 50 = 768.9 ± 2.7 μM). Acetic acid‐induced ulcerative colitis in rat model was chosen to examine the antioxidant potential of the synthesized hybrids ( 9b and 9f ) in the amelioration of ulcerative colitis. Colonic myeloperoxidase and malondialdehyde enzymes were used as biomarkers of anti‐ulcerative colitis activity. In the present study, hybrids 9b and 9f reduced the levels of colonic myeloperoxidase and malondialdehyde enzymes significantly ( p < 0.05) when compared with control (colitic), at a dose (0.03 mM/12.5 mg/kg b.w. p.o.) (50%) less than that of its parent moieties mesalamine (0.16 mM/25 mg/kg) and isatin (0.16 mM/25 mg/kg). Thus, the molecular hybridization was proved to be significant in enhancing the activity of hybrids 9b and 9f by reducing the dose.
Precast concrete, steel-braced, hybrid pipe rack structures (2013)

In this paper, the authors present a case study of the design and construction of a pipe rack in an operating petroleum refinery in a high seismic zone in Mendoza, Argentina. The structure was required to be made of precast, reinforced concrete to accelerate construction and minimize cast-in-place concrete work. It also required a lack of bracing in the cross section to allow for pipe maintenance. The precast concrete frames were proposed to have a single cast-in-place concrete connection as the transverse load-resisting system, longitudinal precast reinforced concrete beams as shear keys, and steel bracing as the longitudinal load-resisting system, all of which ensured compliance with seismic code and boundary conditions. The paper describes the calculation methodology and results of erecting the frames.
A tutorial on the Digital Audio-Visual Council (DAVIC) standardisation activity (1997)

International compatibility for the distribution of video and multimedia content through communication networks is something which has thus far not been achieved. New digital systems provide an opportunity for global compatibility between audio and video transmission and full multimedia communications incorporating text, data, audio, still and moving video in an interactive environment. It is with this commercial opportunity in mind that the Digital Audio-Visual Council (DAVIC) has been created and its first standards, DAVIC1.0 and 1.1, have been released. In Europe the European Commission is actively supporting the development of DAVIC through its Advanced Communications Technologies and Services (ACTS) initiative but DAVIC has widespread international support.
Goos-Hänchen shift in negatively refractive media (2002)

The Goos-Hänchen shift is calculated when total internal reflection occurs at an interface between "normal" and negatively refractive media. The shift is negative, consistent with the direction of energy flow in the negatively refractive medium.
Condition assessment of wind turbine generators based on cloud model (2013)

In order to assess and improve the reliability of wind turbine generators (WTG), and to optimize the maintenance strategy, it is necessary to use online monitoring data acquired from supervisory control and data acquisition (SCADA) system to assess the real-time operational conditions of WTG. Because the determination of fuzzy membership function is subjective and fails to take randomness into account in traditional fuzzy synthetic condition assessment, this paper presents a method for real-time condition assessment of WTG based on fuzzy cloud theory. The cloud model is used to describe the fuzziness and randomness in the fuzzy synthetic condition assessment process of WTG. Based on the actual monitoring data of a 1.5 MW wind turbine generator system within a period of time, the operational conditions are evaluated by using the improved method and the case study indicates the proposed assessment method are reasonable and effective.
Lactoferrin and transferrin: Functional variations on a common structural framework (2002)

Lactoferrin shares many structural and functional features with serum transferrin, including an ability to bind iron very tightly, but reversibly, a highly-conserved three-dimensional structure, and essentially identical iron-binding sites. Nevertheless, lactoferrin has some unique properties that differentiate it: an ability to retain iron to much lower pH, a positively charged surface, and other surface features that give it additional functions. Here, we review the structural basis for these similarities and differences, including the importance of dynamics and conformational change, and specific interactions that regulate iron binding and release.
Importance of the additional step-edge barrier in determining film morphology during epitaxial growth (1995)

A model of epitaxial growth based on steady-state assumptions is derived and shows that the decisive quantity determining the film morphology is the additional energy barrier at the step edges, i.e., the barrier to descend the step minus the surface-diffusion barrier. The model allows this barrier to be directly determined from experimentally observed film morphologies. It is applied to homoepitaxy on Ag(111) and Pt(111) where the additional barriers amount to \ensuremath{\sim}150 and \ensuremath{\sim}165 meV, respectively. In addition, this model provides new understanding of more complex processes, such as the surfactant effect of Sb on Ag(111) and reentrant growth on Pt(111).
Phenomenological theory of laser-plasma interaction in “bubble” regime (2004)

The electron trapping in the “bubble” regime of laser-plasma interaction as proposed by Pukhov and Meyer-ter-Vehn [A. Pukhov and J. Meyer-ter-Vehn, Appl. Phys. B 74, 355 (2002)] is studied. In this regime the laser pulse generates a solitary plasma electron cavity: the bubble. It is free from the cold plasma electrons and runs with nearly light velocity. The present work discusses the form of the bubble and the spatial distribution of electromagnetic fields within the cavity. We extend the one-dimensional electron capture theory to the three-dimensional case. It is shown that the bubble can trap plasma electrons. The trapping condition is derived and the trapping cross section is estimated. Electron motion in the self-generated electron bunch is investigated. Estimates for the maximum of electron bunch energy and the bunch density are provided.
Structural and regulatory functions of the NH2- and COOH-terminal regions of skeletal muscle troponin I. (1994)

Calcium binding to regulatory sites located in the NH2-terminal domain of troponin C (TnC) induces a conformational change that blocks the inhibitory action of troponin I (TnI) and triggers muscle contraction. We used deletion mutants of TnI in conjunction with a series of TnC mutants to understand the structural and functional relationship between different TnI regions and TnC domains. Our results indicate that TnI is organized into structural and regulatory regions which interact in an antiparallel fashion with the corresponding structural and regulatory regions of TnC. Functional studies show that the COOH-terminal region of TnI, when linked to the inhibitory region (TnI103-182) can regulate actomyosin ATPase. A TnI lacking the first 57 amino acids (TnId57) has been shown to have similar properties (Sheng, Z., Pan, B.-S., Miller, T. E., and Potter, J. D. (1992) J. Biol. Chem. 267, 25407-25413). Regulation was not observed with the COOH-terminal region alone (TnI120-182), with the NH2-terminal region alone (TnI1-98), or with the NH2-terminal linked to the inhibitory region (TnI1-116). Binding studies show that the NH2-terminal region of TnI interacts with the COOH-terminal domain of TnC in the presence of Ca2+ or Mg2+ and that the inhibitory plus COOH-terminal region of TnI (TnI103-182) interacts with the NH2-terminal domain of TnC in a Ca(2+)-dependent manner. Based on these results we propose a model for the Ca(2+)-induced conformational change. In our model the NH2-terminal domain of TnI is anchored strongly to the COOH-terminal domain of TnC in the absence and presence of Ca2+ while the inhibitory and COOH-terminal regions of TnI switch between actin-tropomyosin in the absence of Ca2+ to binding sites in both NH2- and COOH-terminal domains of TnC in the presence of Ca2+.
Time‐Frequency Analysis of the Inter‐Seasonal Variations of China‐Neighboring Seas Level (2003)

Abstract The fast Fourier Transform (FFT) and the Continuous Wavelet Transform (CWT) are adopted to analyze the basic features of sea level changes in China Seas at interseasonal scales from tide gauge records and Topex/Poseidon altimetry data (from October of 1992 to September of 1998). The results indicate that the sea level variations over the Yellow Sea and the East China Sea are similar, which have two strong oscillatory signals with the periods of one year and about 60 days, annual and semiannual signals are prominent in the South China Sea. The sea level variations show significant differences on interseasonal scales between shallow sea and deep‐sea.
The use of essential oils to treat snoring (2004)

Snoring is a very common social inconvenience. This double-blind study suggests a significant reduction in snoring reported by bed partners in a group of snoring volunteers using either an essential oil spray or gargle formulation. Possible modes of action of the essential oils are discussed.
Digital Image Processing: A Practical Introduction Using Java (2000)

1. Introduction 2. Imaging 3. Digital Images 4. Images in Java 5. Basic Image Manipulation 6. Grey level and colour enhancement 7. Neighbourhood Operations 8. The Frequency Domain 9. Geometric operations 10. Segmentation 11. Morphological Image Processing 12. Image Compression Appendix A. Glossary of Image Processing Terms
Axonal Growth-Associated Proteins (1989)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Flexible TFT Circuit Analyzer Considering Process Variation, Aging, and Bending Effects (2014)

This paper presents a SPICE-based simulator, FlexiAnalyzer, for flexible thin-film transistor (TFT) circuits. This simulator performs four types of analysis: yield analysis, aging analysis, performance analysis, and weak spot analysis. This simulator considers three important effects: 1) threshold voltage variation of manufacturing process; 2) threshold voltage shift due to aging effect; and 3) mobility change due to bending effect. Six different OLED pixel drivers designed in 8- μm amorphous silicon TFT technology were used in simulation results. The proposed tool provides a good solution for designers to evaluate the performance and yield of flexible TFT circuits.