gebhart/patrepeval huggingface dataset:
Bradykinin-Induced Functional Competence and Trafficking of the δ-Opioid Receptor in Trigeminal Nociceptors (2005)

Peripheral opioid analgesia is increased substantially after inflammation. We evaluated the hypothesis that an inflammatory mediator, bradykinin (BK), evokes functional competence of the delta-opioid receptor (DOR) for inhibiting trigeminal ganglia (TG) sensory neurons. We also evaluated whether BK evokes trafficking of the DOR to the plasma membrane. Rat TG cultures were pretreated with BK (10 microm) or vehicle, and the effects of DOR agonists ([D-Pen2,5]-enkephalin or [D-Ala2, D-Leu5]-enkephalin) on BK (10 microm)/prostagladin E2 (PGE2; 1 microm)-stimulated immunoreactive calcitonin gene-related peptide (iCGRP) release or PGE2 (1 microm)-stimulated cAMP accumulation were measured. The effect of BK treatment on opioid receptor trafficking was evaluated by DOR immunohistochemistry, cell-surface DOR biotinylation, and live imaging of neurons transfected with mDOR-green fluorescent protein. BK pretreatment rapidly and significantly increased DOR agonist inhibition of evoked iCGRP release and cAMP accumulation. These effects of BK pretreatment were blocked by a B2 receptor antagonist (HOE-140; 10 microm) or a protein kinase C (PKC) inhibitor [bisindolymaleimide (BIS); 1 microm]. Moreover, BK treatment rapidly and significantly increased the accumulation of DOR in the plasma membrane. However, BK-induced trafficking of DOR was not reversed by pretreatment with BIS, nor was trafficking evoked by application of a PKC activator PMA (200 nm). These data suggest that BK, in a PKC-dependent manner, induces rapid functional competence of DOR for inhibiting TG nociceptors and in a PKC-independent manner rapidly induces trafficking of DOR to the plasma membrane. These findings indicate that exposure to certain inflammatory mediators rapidly alters the signaling properties and neuronal localization of DOR, possibly contributing to peripheral opioid analgesia.
Peanut and Walnut Rancidity: Effects of Oxygen Concentration and Relative Humidity (1996)

ABSTRACT Accelerated tests for oxidative rancidity of blanched peanuts, blanched dry‐roasted peanuts, blanched oil‐roasted peanuts and shelled Persian walnuts were performed at high and low oxygen content at controlled intermediate and low relative humidities. The results confirmed and quantified the importance of oxygen content, relative humidity and roasting process in the oxidative rancidity of peanuts and walnuts. There is a potential to extend shelf‐life of roasted peanuts and walnuts by edible coatings with low oxygen permeability or nitrogen‐flushing with oxygen barrier packaging. Static headspace chromatography was useful to monitor oxidative rancidity in walnuts and roasted peanuts.
Molecular and crystal structure of PQQ (methoxatin), a novel coenzyme of quinoproteins: extensive stacking character and metal ion interaction (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular and crystal structure of PQQ (methoxatin), a novel coenzyme of quinoproteins: extensive stacking character and metal ion interactionToshimasa Ishida, Mitsunobu Doi, Koutarou Tomita, Hiroki Hayashi, Masatoshi Inoue, and Teizi UrakamiCite this: J. Am. Chem. Soc. 1989, 111, 17, 6822–6828Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ja00199a050https://doi.org/10.1021/ja00199a050research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synchronized chaotic intermittent and spiking behavior in coupled map chains (2005)

We study phase synchronization effects in a chain of nonidentical chaotic oscillators with a type-I intermittent behavior. Two types of parameter distribution, linear and random, are considered. The typical phenomena are the onset and existence of global (all-to-all) and cluster (partial) synchronization with increase of coupling. Increase of coupling strength can also lead to desynchronization phenomena, i.e., global or cluster synchronization is changed into a regime where synchronization is intermittent with incoherent states. Then a regime of a fully incoherent nonsynchronous state (spatiotemporal intermittency) appears. Synchronization-desynchronization transitions with increase of coupling are also demonstrated for a system resembling an intermittent one: a chain of coupled maps replicating the spiking behavior of neurobiological networks.
Magnetic relaxation in high-purity irradiated iron. II. Electron irradiation (1971)

Measurements of the magnetic after-effect, observed as a time decrease of the initial susceptibility, have been performed on high-purity iron after irradiation with 3 MeV electrons. Irradiation doses ranged from 1 × 1016 to 5 × 1018 ecm−2; the temperature of irradiation was 95 °C. Below 0 °C no detailed relaxation was observed. A relaxation peak occurred at 40 to 80 °C and is attributed to vacancy–impurity clusters. This relaxation was accompanied by recovery; a Meechan-Brinkman annealing experiment gave an activation energy of (1.2 ± 0.2) eV. After measurements up to 150 °C a large and hitherto absent relaxation occurred at low temperatures. It is suggested that this is associated with the presence of hydrogen in the lattice. Measurements from 150 to 350 °C show that the relaxation peak at about 240 °C in unirradiated iron, attributed to a dislocation relaxation, is almost suppressed. This is interpreted as being due to dislocation pinning by the radiation-induced defects. The results are compared with parallel measurements on neutron-irradiated iron. Die magnetische Nachwirkung wurde in hochreinem Eisen nach Bestrahlung mit 3 MeV-Elektronen untersucht. Die Bestrahlungsdosen variierten zwischen 1 × 1016 und 5 × 1018 ecm−2. Die Bestrahlungstemperatur betrug 95 °C. Unterhalb von 0 °C wurde keine ausgeprägte Relaxation beobachtet. Ein Relaxationsmaximum wurde bei 40 bis 80 °C gefunden und der Orientierungsnachwirkung von Leerstellen-Verunreinigungs-Paaren zu-geordnet. Dieser Nachwirkungsprozeß heilt mit einer Aktivierungsenergie von (1,2 ± 0,2) eV aus. Nach Anlassen auf 150 °C wurde bei tiefen Temperaturen eine große, bisher nicht vorhandene Nachwirkung aufgebaut, die auf dem Zusammenwirken von Blochwänden, Versetzungen und Wasserstoffatomen beruht. Messungen von 150 bis 350 °C zeigen, daß das Nachwirkungsmaximum bei etwa 240 °C in unbestrahltem Eisen, das einer Versetzungs-relaxation zugeschrieben wird, durch die Bestrahlung weitgehend unterdrückt wird. Dieser Effekt wird der Bestrahlungsverfestigung zugeschrieben. Die hier vorgelegten experimentellen Ergebnisse werden mit früheren Messungen an neutronenbestrahltem Fe verglichen.
Instabilité gravitationnelle entre fluides miscibles dans une cellule de Hele-Shaw : des petits aux grands nombres de Péclet (2001)

Nous avons analyse la stabilite lineaire d'une interface entre deux fluides miscibles gravitationnellement instable dans une geometrie de type Hele-Shaw. Le modele utilise une equation de Brinkman modifiee qui decrit l'ecoulement a la fois dans le regime de Darcy et dans le regime de Stokes. Nous mettons en evidence un comportement non trivial de la longueur d'onde λ et du taux de croissance a le plus instable a tres grand nombre de Peclet, quand la diffusion moleculaire devient negligeable. En particulier, la longueur d'onde adimensionnee par l'epaisseur b de la cellule reste constante au-dela de Pe ∼ 100. Les solutions theoriques de λ et σ sont comparees avec de recents resultats experimentaux pour une gamme de Pe couvrant plus de quatre ordres de grandeur
Temperature monitoring in fat with MRI (2000)

The aim of the study was to test the hypothesis that fast spin echo T(1)-weighted images can be used to quantify the temperature in fat during thermal therapy in vivo. An MR compatible positioning device was used to manipulate focused ultrasound transducers in an MRI scanner. This system was used to sonicate fat tissue around the kidneys of 12 rabbits at various power levels for 10 to 20 sec. The scan parameters of T(1)-weighted fast spin echo (FSE) sequence were varied to optimize signal intensity characteristics while maintaining short scan times. An invasive optical probe was used to calibrate the temperature related signal intensity changes. For the T(1)-weighted FSE sequence, the signal intensity decreased with the temperature elevation at the rate of 0.97+/-0.02%/ degrees C. The single focused transducer produced a contrast-to-noise ratio more than 10 at power levels below the tissue damage threshold. The signal intensity was linearly dependent on the power, despite the measured temperatures being well above the coagulation threshold. This study demonstrates that T(1)-weighted FSE MRI sequences can be used to quantify the temperature elevation in fat in vivo during short focused ultrasound exposures. This can be very important for breast tumor surgery, fat ablation, and for treating deep seated tumors through superficial fat layers. Magn Reson Med 43:901-904, 2000.
RhoA Regulates Peroxisome Association to Microtubules and the Actin Cytoskeleton (2010)

The current view of peroxisome inheritance provides for the formation of new peroxisomes by both budding from the endoplasmic reticulum and autonomous division. Here we investigate peroxisome-cytoskeleton interactions and show by proteomics, biochemical and immunofluorescence analyses that actin, non-muscle myosin IIA (NMM IIA), RhoA, Rho kinase II (ROCKII) and Rab8 associate with peroxisomes. Our data provide evidence that (i) RhoA in its inactive state, maintained for example by C. botulinum toxin exoenzyme C3, dissociates from peroxisomes enabling microtubule-based peroxisomal movements and (ii) dominant-active RhoA targets to peroxisomes, uncouples the organelles from microtubules and favors Rho kinase recruitment to peroxisomes. We suggest that ROCKII activates NMM IIA mediating local peroxisomal constrictions. Although our understanding of peroxisome-cytoskeleton interactions is still incomplete, a picture is emerging demonstrating alternate RhoA-dependent association of peroxisomes to the microtubular and actin cytoskeleton. Whereas association of peroxisomes to microtubules clearly serves bidirectional, long-range saltatory movements, peroxisome-acto-myosin interactions may support biogenetic functions balancing peroxisome size, shape, number, and clustering.
TU‐FF‐A3‐05: Optimizing KV Fluoro Acquisition for Prostate Intrafraction Motion Evaluation (2008)

Purpose: Commercially available gantry mounted kV imagers are currently restricted to manual fluoroscopy acquisitions with fixed mAs & frame rate, limiting use of fluoroscopy for prostate intrafraction motion measurement. For consideration in future acquisition improvements, we investigate the parameters required to optimize the 3D accuracy of prostate intrafraction localization while minimizing imaging dose. Method and Materials: Prostate intrafraction motion is measured at our clinic using simultaneous kV fluoroscopy to visualize implanted markers for a hypofractionated radiotherapy protocol. For a 5‐beam step‐and‐shoot IMRT delivery we compare the current technique with acquiring images between MLC segments. Effects of imaging frequency and of including acquisitions during gantry rotation were also considered. The 3D localization accuracy was evaluated using simulations with existing sagittal cine‐MRI images from 6 patients consisting of 490 motion tracks for ∼8 minutes/track. Dose was evaluated using surface and central axis measurements on a 30‐cm diameter acrylic phantom, assuming adequate mAs values to achieve 80% registration success rate. Results: Simulations with the cine‐MRI data showed that 3D accuracy is acceptable even for low imaging frequencies: 95% of measurements were within 1.0 mm when imaging every 30s, and within 1.2 mm for 60s. 3D accuracy is adequate when imaging between MLC segments only (95% within 1.0 mm, 98% within 1.6 mm), with minor improvement when acquiring also during gantry rotation (95% within 1.0 mm, 98% within 1.5 mm). Maximum dose was lowered to 1.4 mGy when imaging only between MLC segments with gantry dependant mAs, compared to 3.3 mGy for the current technique and 21.1 mGy for a CBCT. Conclusion: Optimal intrafraction fluoroscopy measurement is achieved with adjustable acquisition frame rate, synchronization with MV beam delivery (acquisition between segments), and programmable gantry dependent mAs, resulting in high 3D accuracy and low imaging dose. Conflict of Interest: Partially supported by NIH Grant CA118037.
EFFECTS OF CARBONATED AND NONCARBONATED BEVERAGE INTAKES IN RESPONSE TO PROLONGED CYCLE ERGOMETER EXERCISE (2006)

Athletes have been instructed to refrain from taking carbonated beverages in the sports world, but the mechanism has not been clear. The purpose of this study was to clarify how physiological and biochemical evaluation are affected by taking a 10% CHO carbonated beverage after cycle ergometer (60 min, 60% VO2max). Seven subjects consumed a carbonated or noncarbonated (10% carbohydrate) beverage after exercise. No differences were observed in concentration of glucose, insulin, free fatty acids, K and Na in serum from carbonated beverage compared with noncarbonated beverage intakes after exercise. These results indicate that carbonated beverage did not affect the changes of physiological and biochemical parameter after prolonged exercise, and it could be more refreshing and stimulate taste rather than noncarbonated beverage, but seemed to be hard to drink immediately after exercise because it made subjects feel as if having drunk more than they did.
Code Development for Modeling Induced Seismicity With Flow and Mechanics Using a Discrete Fracture Network and Matrix Formulation With Evolving Hydraulic Diffusivity (2018)

Injection-induced seismicity (IIS) depends on pore pressure, in-situ stress state, and fault orientation; generally occurs in basement rock that contains fractures and faults; and moves away from the injection well as a nonlinear diffusion process.Therefore, to numerically model IIS a code should incorporate flow and geomechanics, the presence of fractures and faults, and the capability for hydraulic diffusivity to evolve with effective stress and failure history.In this work, we introduce and verify a modeling framework that allows hydraulic diffusivity to evolve as fractures open and close.Details and challenges in code development are discussed, including how the Bandis model for normal fracture deformation can be used to calculate hydraulic diffusivity as a function of effective normal stress.The discrete fracture network and matrix (DFNM) model is implemented in PFLOTRAN such that hydraulic diffusivity has different constitutive relationships for fracture and matrix grid cells.This model is applied to understand the recent IIS near Greeley, Colorado, and its results are compared to: (a) a traditional DFNM model where hydraulic diffusivity cannot evolve and (b) an equivalent porous media (EPM) model where the effect of the fractures are averaged over a large region of rock.The new DFNM model predicts critical pressure will propagate farther from an injection well.This modeling framework shows promise for applications where fracture and matrix flow are important and hydraulic diffusivity is a function of pressure, stress, and/or shear failure history.
Single-generation effects on terpenoid defenses in lodgepole pine populations following mountain pine beetle infestation (2018)

The recent mountain pine beetle outbreak in western Canada provides an opportunity to study the selection and heritability of tree defenses. We examined terpenoid-based defenses of seedling lodgepole pines which were offspring of mature trees subjected to high levels of mountain pine beetle selective pressure. Seedlings were grown from one of three types of cones: old cones on live trees; young cones on live trees; and cones on trees killed by beetles. Offspring thus represented crosses of non-surviving (NS) x surviving (S), S x S, and NS x NS parents, respectively. Methyl jasmonate was used to induce a defensive reaction in the seedlings. Seed source had a significant effect on levels of ten different terpenes, but not on total terpene concentrations. When the seedlings were grouped by location and treatment type, the seedlings of different cone types could be almost entirely distinguished by terpene profiles.
2110 Sensory Evaluation of Ride on Railway Vehicle Using Simulator (2007)

Sensory evaluation of ride on railway vehicle is performed based on international standards such as ISO2631. However, as technologies relating to railway vehicle progress, it is expected that this evaluation would be not enough. The evaluation for sight and sound from ergonomic and psychological perspectives might be needed as well as traditional evaluations from now. Authors focused on the relation between sight and motion of the railway vehicle, and made experiments in sensory evaluation of ride on railway vehicle using simulator, which is efficient in reproducing various situations by which patterns of images and motion are variously combined. In this paper, the way and results of experiment are described.
Evaluation of Performance of Predictive Models for Deoxynivalenol in Wheat (2013)

The aim of this study was to evaluate the performance of two predictive models for deoxynivalenol contamination of wheat at harvest in the Netherlands, including the use of weather forecast data and external model validation. Data were collected in a different year and from different wheat fields than data used for model development. The two models were run for six preset scenarios, varying in the period for which weather forecast data were used, from zero-day (historical data only) to a 13-day period around wheat flowering. Model predictions using forecast weather data were compared to those using historical data. Furthermore, model predictions using historical weather data were evaluated against observed deoxynivalenol contamination of the wheat fields. Results showed that the use of weather forecast data rather than observed data only slightly influenced model predictions. The percent of correct model predictions, given a threshold of 1,250 μg/kg (legal limit in European Union), was about 95% for the two models. However, only three samples had a deoxynivalenol concentration above this threshold, and the models were not able to predict these samples correctly. It was concluded that two- week weather forecast data can reliable be used in descriptive models for deoxynivalenol contamination of wheat, resulting in more timely model predictions. The two models are able to predict lower deoxynivalenol contamination correctly, but model performance in situations with high deoxynivalenol contamination needs to be further validated. This will need years with conducive environmental conditions for deoxynivalenol contamination of wheat.
Microwave endometrial ablation for hypermenorrhea caused by impaired blood coagulation (2000)

The purpose of this study was to investigate the clinical application of a microwave tissue coagulator at 2.45 GHz with a needle electrode specifically customized for endometrial ablation. Endometrial ablation was performed under intravenous thiopental anesthesia on three women suffering from hypermenorrhea caused by aplastic anemia (two), von Willebrand's disease (one) using a microwave tissue coagulator at 2.45 GHz. All patients were amenorrheic after endometrial ablation. No notable complications were observed during or after endometrial ablation. Endometrial ablation using a microwave tissue coagulator at 2.45 GHz is a simple and efficacious method for the treatment of hypermenorrhea.
Cooking of dry high-lignin Eucalyptus camaldulensis chips followed by TCF bleaching with hydrogen peroxide (2017)

This paper describes laboratory experiments with Eucalyptus camaldulensis grown in South Asia. Pulping of E. camaldulensis is known to be challenging because of its high lignin content. Moreover, E. camaldulensis chips originating from arid and semi-arid regions of South Asia have often a very low moisture content, which further complicates their pulping. In this research, chips with 5.5% moisture content were screened and the accept fraction underwent a pressurized soaking treatment, which seemingly dissolved carbohydrates, extractives and lignin. The rewetted chips were cooked to a kappa number of 18, oxygen delignified and bleached with hydrogen peroxide. The yield was 45.4% based on unbleached pulp. Pulp viscosities after cooking, oxygen delignification and bleaching were 830, 700, and 600 mL/g, respectively. The high active alkali charge in cooking apparently resulted in low pulp viscosities. In addition to lignin, E. camaldulensis probably contained other polyphenolic compounds, which further consumed alkali. The bleached pulp brightness was 85.5% ISO.
Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4) (2017)

GPR116 (ADGRF5) and ELTD1 (ADGRL4) belong to different subfamilies of the adhesion G-protein-coupled receptor group but are both expressed in endothelial cells. We therefore analyzed their functions in mice lacking these receptors. While loss of GPR116 or ELTD1 alone had no obvious effect on cardiovascular or kidney function, mice lacking both, GPR116 and ELTD1, showed malformations of the aortic arch arteries and the cardiac outflow tract leading to perinatal lethality in about 50% of the mutants. In addition to cardiovascular malformations, surviving mice developed renal thrombotic microangiopathy as well as hemolysis and splenomegaly, and their lifespan was significantly reduced. Loss of GPR116 and ELTD1 specifically in endothelial cells or neural crest-derived cells did not recapitulate any of the phenotypes observed in GPR116-ELTD1 double deficient mice, indicating that loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects.
Frequency Scalable Model for MEMS Capacitive Shunt Switches at Millimeter-Wave Frequencies (2009)

This paper presents an approach to RF microelectromechanical systems (MEMS) capacitive shunt switch design from <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> -band up to <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">W</i> -band based on the scalability of the RF MEMS switch with frequency. The parameters of the switch's equivalent-circuit model also follow scaling rules. The measurement results of the fabricated switches show an excellent agreement with simulations that allow to validate the MEMS model in the entire band from 20 up to 94 GHz. This model is going to be used in the phase shifter circuit design for antenna array applications. The first 60-GHz phase shifter results are also reported here.