gebhart/patrepeval huggingface dataset:
Changes in cell kinetics associated with differentiation of a human promyelocytic cell line (HL60) (1982)

Abstract. Terminal cell differentiation results in an irreversible arrest in the G 1 phase of the cell cycle and loss of the capacity for cell renewal. In the murine erythroleukaemia cell line (MELC), commitment to erythroid differentiation was found also to be preceded by an early, transient, phase of inhibition of growth due to prolongation of the G 1 phase. We determined the effect of differentiation‐inducing agents on the growth kinetics of a human promyelocytic cell line (HL60) which undergoes differentiation into mature granulocyte. At concentrations of inducers optimal for cell differentiation, an early, transient stimulation of cell multiplication was found. DNA synthesis was enhanced in HL60 cells as early as 5 hr after exposure to inducer. Nevertheless, HL60 cell maturation eventually also resulted in a loss of the multiplication ability. The duration of exposure to inducer required for irreversible loss of the potential for self‐renewal was determined by the fall in the cloning efficiency of induced cells; the results indicate that it preceded the switch‐off of the replication mechanism; the majority of the cells lost their ability to form large colonies at the time of peak DNA synthesis and were able to complete an additional two to three cell cycles at a rate similar to uninduced cells. These changes occurred before HL60 cells became committed and might play a pivotal role in the process of cell differentiation.
Asymmetric synthesis of γ-aryl-substituted GABA derivatives via a highly diastereoselective Rh-catalyzed boronic acid addition at room temperature (2015)

A highly diastereoselective Rh-catalyzed boronic acid addition to enantiopure sulfinylimines at room temperature providing γ-aryl GABA derivatives has been described.
Velocity Imaging by an Analytic Tomographic Approach (1999)

Abstract Within the straight rays approximation of the propagation and using a 2-D velocity model it is possible to develop a detailed analysis of traveltime reflection tomography.
In silico characterization of protein chimeras: Relating sequence and function within the same fold (2009)

The exploration of novel proteins via recombination of fragments derived from structurally homologous proteins has enormous potential for medicine and biotechnology. This modular exchange of sequence material puts novel activities, substrate specificities, and stability within reach of a semi-random search. This article takes stock of the growing resource of experimentally characterized chimeric proteins within a homologous protein family to build sequence-function models that can effectively guide the construction of new libraries. A novel framework for predicting structural viability of chimeric proteins, only assuming knowledge of their sequence and their parental structure, is presented. Removing a major barrier in previous work, the model processes any sequence that derives from parents with similar folds. The method naturally mixes test and training data from site-directed recombination, DNA shuffling, or random mutagenesis experiments. We train a model from a site-directed recombination library with state-of-the-art prediction accuracy on hold-out test data from the same experimental source and convincing performance on chimeras with a different origin. Specifically, the model is used to assess the structural viability of P450 chimeras deriving from proteins with only 18% sequence similarity to those used for model tuning.
Enhanced accuracy is necessary for refractive surgery instrumentation (1989)

New optical zone markers, diamond knives, and gauge blocks were ordered from a random selection of manufacturers and inspected by an independent metallurgical engineer. This study revealed workmanship flaws and poor instrument accuracy. None of the 26 optical zone markers examined came with instructions as to whether the incisions were to be carried to or from the inside diameter or the outside diameter of the corneal impression made by the marker. Two markers had a 100 microns or greater error in their centering devices and one had a centering device off center by 210 microns. Two of the seven diamond micrometer knives had broken blade tips and uneven footplates; two knives had misaligned blades and uneven footplates, one knife had extremely roughly finished footplates, and one knife had a 100 microns error in its micrometer. All the knives had a wobble in the blade shaft upon advancement and had rounded footplates, making blade extension verification difficult. Five of seven blade gauges were accurate to within 10 microns; two had errors of more than 60 microns which could lead to incisions too deep or too shallow and micro- or macroperforations of the cornea during refractive surgery. It is recommended that all refractive surgery instruments be carefully inspected under a high power micron-level microscope at the time of purchase and routinely thereafter.
Laboratory methodologies for propellant corrosion research (1996)

Storable liquid propellants are stored for extended periods of time in metal tankage prior to usage in rocket engines. Knowing the chemical interaction of the propellant and the tankage material is essential to evaluating the structural integrity of the tankage hi service and determining if the propellant remains within specifications at the time of use. Some of this information has been obtained through long duration storage studies for periods of over 20 years in some cases. It is desirable to establish valid methods to obtain quantitative data to project long-term corrosion rates in lieu of real-time storage experimentation. Experimental methods and techniques currently used in obtaining such corrosion data and their theoretical basis are described in this article. These include 1) electrochemical: dc polarization and ac impedance measurements; 2) weight loss; and 3) surface analytical: x-ray photoelectron spectroscopy, auger electron spectroscopy, and optical microscopy. This article presents a description of the fundamental methods used by two research organizations and a comparison of these methods and equipment. These techniques are valid for evaluation of corrosion rates on various fuel and oxidizer propellants. The results of specific research with nitric acid based oxidizers with various aluminum alloys are presented in a companion article.
Students Grasp Sustainable World Food Policies (1994)

Using print media about the food situation in the Commonwealth of Independent States (C.I.S.), students in an undergraduate survey course studied their unfolding food situation from January to May, 1992. Optional student participation was summarized by the number of articles submitted according to student major. Sources and titles of media articles were listed. The content of the 53 media articles was summarized in chronological order for the semester. Students' concerns and comments were emphasized throughout the discussion. Their informal class discussions frequently included concepts of sustainable agriculture. Much of the information in the news media coincided with class lectures about the global food situation, i.e., sustainable agriculture and chemicals in the food supply. Conclusions were made about how students reacted to the unfolding events, from projections of famine made in January 1992 to statements of severe ecological damage, in April 1992. They observed disastrous societal effects because sustainable agriculture was not observed.
Mn<sub>1-t</sub>Cr<sub>t</sub>As UNDER PRESSURE, COMPETITION BETWEEN MAGNETIC ORDERINGS (1988)

The pressure phase diagrams for Mn1-tCrtAs with t = 0.355 and 0.390 were determined. The observed topology around the two types of heli-ferro-para triple points may indicate multicritical behaviour. The value of dTC/dP = +11 K/kbar for the induced ferromagnetic phase (t = 0.390) represents the highest positive pressure slope observed for a metallic magnet.
Gastric cancer: the case for a more selective policy in surgical management. (1993)

Over a 5-year period 114 patients with gastric cancer were evaluated. Seventy-seven (68%) of these underwent laparotomy, of which 5A (47%) had a resection performed though only 22 (19%) of these were considered curative. Thirty-seven patients (32%) were not offered surgery because they were aged, had poor cardiorespiratory function, or were thought to have advanced disease based on a combination of clinical (fixed epigastric mass, hepatomegaly, jaundice or ascites), radiological and endoscopic features. Overall 5-year survival was 10.9%, with the patients who had curative and palliative resections having 5-year survivals of 24.4% and 18.2% respectively. Eight of the 12 patients who had palliative gastroenterostomy were not satisfactorily palliated, and 9 patients who had 'open and close' laparotomy fared badly with an operative mortality of 44%; mean survival in these two groups was 3.8 and 3 months respectively. Mean survival in patients treated without operation was 5 months. Unit policy in the management of patients with carcinoma of the stomach has been to resect for cure and palliation whenever possible. However, because so many patients present with advanced disease, the avoidance of inappropriate surgery has been an equal priority. In this context, the wider use of ultrasonography, laparoscopy and perhaps computed tomography (CT) may be of help. In this paper, the experience of these 114 patients is reviewed.
Effects of adsorbate coverage on the infrared spectrum of chemisorbed ammonia (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of adsorbate coverage on the infrared spectrum of chemisorbed ammoniaRobert K. Beckler and Mark G. WhiteCite this: Langmuir 1987, 3, 6, 1074–1080Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/la00078a034https://doi.org/10.1021/la00078a034research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Compensation for Dispersion-Enhanced Phase Noise in Reduced-Guard-Interval CO-OFDM Transmissions (2011)

We propose a dual-polarization grouped maximum-likelihood (DP-GML) algorithm to compensate for the dispersion-enhanced phase noise (DEPN) of reduced-guard-interval (RGI) CO-OFDM. The laser linewidth tolerance is increased to 2 MHz after a 4800 km transmission.
Identification Of Nonlinear Satellite Mobile Channels Using Volterra Filters (2015)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
New Volatile Sulfur-Containing Constituents in a Simultaneous Distillation−Extraction Extract of Red Bell Peppers (Capsicum annuum) (2007)

An extract of red bell peppers ( Capsicum annuum) was prepared by simultaneous distillation-extraction (SDE, Likens-Nickerson). In addition to the already known (3 E)-3-hepten-2-one ( 1), the unsaturated C9-ketones 1-nonen-4-one ( 2), (2 E)-2-nonen-4-one ( 3), and (2 E,5 E)-2,5-nonadien-4-one ( 4), 2-methoxy-3-isobutylpyrazine ( 5), and heptane-2-thiol ( 6), we identified 19 new thiols (the aliphatic saturated and unsaturated thiols 14- 16, and 22- 27, the mercapto-ketones 12 and 13, the mercapto-alcohols 17, 18, and 30, the dithiols 19 and 28, the methylthio-thiols 20 and 21, and the thiophene-thiol 31) and the two new dithiolanes 10 and 29. All of them are structurally related to the unsaturated C7- and C9-ketones 1- 4. The free thiols were enriched using Affi-Gel 501 ( p-aminophenyl-mercuric acetate grafted on an agarose gel). The new compounds were confirmed by syntheses and were organoleptically evaluated.
MCM-L integrated transformers for low power applications (2002)

Designs for planar magnetic core structures fabricated in printed circuit board (PCB) technology have been developed by the authors. The technology is applied to producing integrated transformers for low power conversion in this paper. It involves using processes and materials which are compatible with existing PCB techniques, and structures are designed to be integrated with other circuitry in a typical PCB layer count. Structures are designed to support voltage levels of up to 18 V at 3 W power.
ChemInform Abstract: A Novel and Convenient Transformation of Nitriles to Aldehydes. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Probabilistic-Logical Framework for Ontology Matching (2010)

Ontology matching is the problem of determining correspondences between concepts, properties, and individuals of different heterogeneous ontologies. With this paper we present a novel probabilistic-logical framework for ontology matching based on Markov logic. We define the syntax and semantics and provide a formalization of the ontology matching problem within the framework. The approach has several advantages over existing methods such as ease of experimentation, incoherence mitigation during the alignment process, and the incorporation of a-priori confidence values. We show empirically that the approach is efficient and more accurate than existing matchers on an established ontology alignment benchmark dataset.
Evidence for abnormal regulation of insulin receptors in Friedreich's ataxia. (1993)

Friedreich's ataxia is associated with a high incidence of diabetes mellitus. We have previously demonstrated that insulin resistance is present in nondiabetic patients with Friedreich's ataxia. This was associated with a reduction in the affinity of insulin receptors on freshly isolated monocytes. In this study we investigated the ability of the monocyte insulin receptor to acutely alter its affinity in response to oral glucose. Glucose and insulin concentrations were higher in the patients with Friedreich's ataxia after an oral glucose load, consistent with the presence of insulin resistance. The normal increase in the affinity of insulin receptors on monocytes 5 h after oral glucose was absent in the five patients with Friedreich's ataxia. Receptor affinity actually decreased in three of the five patients. These findings support the concept that a membrane abnormality that alters the binding function of the insulin receptor is present in these patients.
Automatic Generation of Traffic Management Strategies (2005)

The cooperative, harmonized and effective use of traffic strategies across different ATMS is a wide and complex problem that, as a rule, requires much preliminary planning effort from the traffic engineer or system operator in order to find the optimal strategies as an appropriate response for the most relevant / critical situations. Problematical are the unpredictable, i.e. sudden and unexpected traffic incidents and disturbances, as it is usually not possible to plan custom-made strategies for them. Nowadays, for this wide range of cases, there is only very few tool support available for the operator. The objective of the proposed concept is an automatic online reaction to detected situations like incidents. Traffic management strategies will be generated automatically and provided to the operator who can check their plausibility and trigger their operation. Depending on the level of automation, strategies are built from existing measures or new measures will be generated automatically and combined to new strategies.
Involvement of Central Serotonergic Mechanisms in the Cough Reflex (1986)

To determine the role of central serotonergic systems in modulating the cough reflex, the effects of serotonergic agonists on the respiration and the cough reflex were comparatively studied. Male and female cats were anesthetized with sodium pentobarbital. Respiration and cough reflex were measured using a pneumotachograph via a cannula inserted into the trachea. The cough reflex was elicited by electrical stimuli to the superior laryngeal nerve. Tranylcypromine, a MAO inhibitor, in a dose of 5 mg/kg, i.v., increased the respiration, but depressed the cough reflex. The serotonin precursor 5-hydroxytryptophan (5 mg/kg, i.v.) depressed the respiration and the cough reflex. Haloperidol (2 mg/kg, i.v.) abolished the tranylcypromine-stimulated respiratory responses, and it intensified the tranylcypromine induced cough depression. It is concluded that the increase in serotonin levels in the brain has a depressant influence on the central generating mechanisms of the cough reflex. Furthermore, central dopaminergic mechanisms seem to play a modulating role on the cough reflex.
Autonomous coordination of imaging and tumor manipulation for robot assisted breast biopsy (2008)

Breast biopsy guided by imaging techniques such as ultrasound is widely used to evaluate suspicious masses within the breast. During percutaneous needle biopsy, large tissue deformation will likely displace the tumor from its original position necessitating multiple insertions, causing surgeonspsila fatigue, patientpsilas discomfort, and compromising integrity of the tissue specimen. Tumor mobility also poses significant difficulty in imaging the target and the needle using an ultrasound probe. In addition, simultaneous coordination of freehand ultrasound imaging, needle insertion, target localization and breast stabilization is a challenging task for the surgeon. In this work, we present a new concept for coordinated real-time tumor manipulation and ultrasound imaging using a hybrid control architecture. The idea here is to demonstrate that it is possible to (1) manipulate a tumor in real-time by applying controlled external force (2) control the position of the ultrasound probe for tracking out-of-plane target movement and maintaining surface contact (3) coordinate the above systems in an autonomous manner such that the tumor does not deviate from the path of the needle. Experiments are performed on phantoms to demonstrate essence of this technique. The success of this approach has the potential to reduce the number of attempts a surgeon makes to capture the desired tissue specimen, minimize tissue damage, improve speed of biopsy, and reduce patient discomfort.
Relationships between the use of Embden Meyerhof pathway (EMP) or Phosphoketolase pathway (PKP) and lactate production capabilities of diverse Lactobacillus reuteri strains (2015)

The aims of this study is to compare the growth and glucose metabolism of three Lactobacillus reuteri strains (i.e. DSM 20016, DSM 17938, and ATCC 53608) which are lactic acid bacteria of interest used for diverse applications such as probiotics implying the production of biomass, or for the production of valuable chemicals (3-hydroxypropionaldehyde, 3-hydroxypropionic acid, 1,3-propanediol). However, the physiological diversity inside the species, even for basic metabolisms, like its capacity of acidification or glucose metabolism, has not been studied yet. In the present work, the growth and metabolism of three strains representative of the species diversity have been studied in batch mode. The strains were compared through characterization of growth kinetics and evaluation of acidification kinetics, substrate consumption and product formation. The results showed significant differences between the three strains which may be explained, at least in part, by variations in the distribution of carbon source between two glycolytic pathways during the bacterial growth: the phosphoketolase or heterolactic pathway (PKP) and the Embden-Meyerhof pathway (EMP). It was also shown that, in the context of obtaining a large amount of biomass, DSM 20016 and DSM 17938 strains were the most effective in terms of growth kinetics. The DSM 17938 strain, which shows the more significant metabolic shift from EMP to PKP when the pH decreases, is more effective for lactate production.
Translating Nature’s Library: The Bryostatins and Function‐Oriented Synthesis (2011)

We review in part our computational, design, synthesis, and biological studies on a remarkable class of compounds and their designed analogs that have led to preclinical candidates for the treatment of cancer, a first-in-class approach to Alzheimer's disease, and a promising strategy to eradicate HIV/AIDS. Because these leads target, in part, protein kinase C (PKC) isozymes, they have therapeutic potential even beyond this striking set of therapeutic indications. This program has given rise to new synthetic methodology and represents an increasingly important direction of synthesis focused on achieving function through synthesis-informed design (function-oriented synthesis).
Development of Replacing Material for Sand Mat by Using Precious Slag Ball (2009)

Recently, new development projects are being carried out with the soft ground located along the West coast and the South coast. As soft grounds have complex engineering properties that the load bearing capacity is low and high compressibility, it needs to solve this problems Prior to structures are constructed by the method of improvement of soft ground. The sand mat is usually being used for improvement of soft ground as a horizontal drain material and loading base. But, as the volume is enormous and an amount of demanded sand is increased, it is state of short in supply. This paper presents the feasibility study to use of precious slag ball instead of sand mat as the replacing material through the basic soil property tests, the medium of discharge capacity test and analysis of settlement character.
Resonantly-enhanced THz-wave generation via multispectral mixing inside a ring-cavity OPO (2009)

Narrowband output at 1.5THz was produced in periodically-inverted GaAs placed inside a high-finesse ring-cavity fiber-laser-pumped degenerate PPLN OPO containing a thin Fabri-Perot etalon. Over 10-microWatt average power was generated using 2 W of laser pump.
High-strength self-curing low-shrinkage concrete for pavement applications (2010)

High-performance concretes (HPC) that are designed to possess high early strength, self-curing capabilities and low shrinkage may potentially improve rigid pavement performance. A multi-scale experimental programme examined mechanical properties and shrinkage behaviour of a low water-to-cementitious materials ratio concrete containing pre-wetted lightweight aggregate for self-curing; results were compared with companion HPC prepared with air-dry lightweight aggregate and with normal weight, normal strength concrete. The use of pre-wetted lightweight aggregate enhanced hydration and strength development during the first year, and limited autogenous shrinkage and substantially reduced drying shrinkage. Digital image analysis revealed that shrinkage was concentrated in the paste rather than in the aggregate in both the normal strength concrete and HPC. The image analysis also showed that strain concentrations at the aggregate/paste interface were less apparent in the HPC, presumably due to the reduced strain mismatch with the use of the lower modulus lightweight aggregate. These observations suggest that the use of HPC containing pre-wetted lightweight aggregate can potentially reduce microcracking and enhance overall pavement performance.