gebhart/patrepeval huggingface dataset:
Agonistic Anti‐4‐1BB Antibody Promotes the Expansion of Natural Regulatory T Cells While Maintaining Foxp3 Expression (2007)

The engagement of the 4-1BB (CD137) co-stimulatory pathway promotes the activation and proliferation of conventional CD4(+) T and CD8(+) T cells, but the role of 4-1BB co-stimulation in CD4(+) CD25(+) regulatory T cells (Treg) is less clear. In particular, whether 4-1BB stimulation affects the expression of Foxp3, a master gene for Treg, is unknown. This study demonstrates that co-stimulation of 4-1BB engaged by an agonistic antibody promotes the proliferation of Treg in a dependent manner of low-concentration interleukin-2 in vitro. The 4-1BB-expanded Treg maintain Foxp3 expression and their ability to suppress conventional CD4(+) T cells and their feature to produce no interleukin-2. However, the 4-1BB-expanded Treg produce increased levels of interferon-gamma, whose significance is unknown. Thus, 4-1BB co-stimulation plays a role in the expansion of functional CD4(+) CD25(+) Treg cells without adversely affecting their suppressive activity.
Designing Smart Polymer Conjugates for Controlled Release of Payloads (2018)

Incorporating labile bonds inside polymer backbone and side chains yields interesting polymer materials that are responsive to change of environmental stimuli. Drugs can be conjugated to various polymers through different conjugation linkages and spacers. One of the key factors influencing the release profile of conjugated drugs is the hydrolytic stability of the conjugated linkage. Generally, the hydrolysis of acid-labile linkages, including acetal, imine, hydrazone, and to some extent β-thiopropionate, are relatively fast and the conjugated drug can be completely released in the range of several hours to a few days. The cleavage of ester linkages are usually slow, which is beneficial for continuous and prolonged release. Another key structural factor is the water solubility of polymer-drug conjugates. Generally, the release rate from highly water-soluble prodrugs is fast. In prodrugs with large hydrophobic segments, the hydrophobic drugs are usually located in the hydrophobic core of micelles and nanoparticles, which limits the access to the water, hence lowering significantly the hydrolysis rate. Finally, self-immolative polymers are also an intriguing new class of materials. New synthetic pathways are needed to overcome the fact that much of the small molecules produced upon degradation are not active molecules useful for biomedical applications.
Quadrant IV – Section 16 (1991)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Graph based Tensor Recovery for Accurate Internet Anomaly Detection (2018)

Detecting anomalous traffic is a crucial task of managing networks. Many anomaly detection algorithms have been proposed recently. However, constrained by their matrix-based traffic data model, existing algorithms often suffer from low detection accuracy. To fully utilize the multi-dimensional information hidden in the traffic data, this paper takes an initiative to investigate the potential and methodologies of performing tensor factorization for more accurate Internet anomaly detection. Only considering the low-rank linearity features hidden in the data, current tensor factorization techniques would result in low anomaly detection accuracy. We propose a novel Graph-based Tensor Recovery model (Graph-TR) to well explore both low rank linearity features as well as the non-linear proximity information hidden in the traffic data for better anomaly detection. We encode the non-linear proximity information of the traffic data by constructing nearest neighbor graphs and incorporate this information into the tensor factorization using the graph Laplacian. Moreover, to facilitate the quick building of neighbor graph, we propose a nearest neighbor searching algorithm with the simple locality-sensitive hashing (LSH). We have conducted extensive experiments using Internet traffic trace data Abilene and GEANT. Compared with the state of art algorithms on matrix-based anomaly detection and tensor recovery approach, our Graph-Trcan achieve significantly lower False Positive Rate and higher True Positive Rate.
High-peak-power temporally shaped nanosecond fiber laser immune to SPM-induced spectral broadening (2019)

High-peak-power transform-limited narrow-linewidth nanosecond all-fiber lasers are desired in a range of applications. However, their linewidths will be broadened by self-phase modulation (SPM). We propose a novel concept that generates transform-limited laser pulses by temporally shaping the pulse seed. The impact of the pulse shape on SPM-induced spectral broadening was studied numerically and experimentally. It was found theoretically that the square-shape pulsed laser is immune to SPM-induced spectral broadening. Based on this principle, we built a high-peak-power, linearly polarized, square-shape nanosecond all-fiber laser in a master oscillator power amplifier (MOPA) configuration. Stimulated Brillouin scattering (SBS) limited peak powers of 4.02 kW, 5.06 kW, 6.52 kW and 9.30 kW were obtained at pulse widths of 8 ns, 7 ns, 6 ns and 5 ns. Thanks to the square-shape pulsed seed, the linewidths at maximum peak power remained at 129.5 MHz, 137.6 MHz, 156.2 MHz and 200.1 MHz, respectively, close to the transform-limited values of 110.8 MHz, 126.6 MHz, 147.7 MHz and 177.3 MHz.
Genetics of type 2 diabetes and insulin resistance: knowledge from human studies (2002)

Both type 2 diabetes mellitus (T2DM) and insulin resistance are complex traits in which multiple gene effects and metabolic and environmental factors combine to contribute to the overall pathogenesis of these conditions. This complexity has complicated the search for susceptibility genes and has led to different but complementary approaches being used for the detection of gene effects. These include the study of monogenic cases of insulin resistance and T2DM, association studies of candidate genes and genome-wide scans. The peroxisome proliferator-activated receptor gamma (PPARgamma) and calpain-10 (CAPN10) genes have recently been identified as T2DM susceptibility genes, and the lessons learnt from these studies are helping to shape future strategies to search for additional susceptibility genes in T2DM and insulin resistance.
Enaminones (1977)

The first page of this article is displayed as the abstract.
Water absorption and dielectric properties of Epoxy insulation (2008)

Characterization of Epoxy (diglycidyl ether of Bis-phenol A cured with Tri ethylene Tetra amine) without fillers was done. The Water absorption test at 95°C shows that at saturation the epoxy contains a water concentration of 2.089%. The diffusion coefficient of absorption is calculated as 0.021 cm2/s. The diffusion coefficient of desorption is calculated as 0.0987 cm2/s. The diffusion is almost 5 times faster than absorption. Also the material looses weight as the hydrothermal aging progresses. The water in the sample leads to chain scission which leads to the weight loss. The weight loss is more incase of absorption followed by desorption than only absorption. The chain scission leads to decrease in the mechanical strength by around 45%. The diffusion of water from the samples doesn t affect the mechanical strength of the materials. The glass transition temperature reduces by 20°C with water inside the sample. The diffusion of water out of the sample only increases by around 10°C. The Dielectric response of the material shows that after the water absorption the sample shows high losses at lower frequencies. Also the increase in the real part of the permittivity increases with low frequency. The rapid increase in the real art of the permittivity of the material at lower frequencies can be attributed to a polarization at the electrode due both to accumulation of the charge carriers and to chain migrations. The breakdown test of the samples shows that with water in the sample the breakdown strength of the material decreases by 10 KV, but the material regains its dielectric strength when the water is diffused out. This shows that the chain scission and weight loss of the samples has no or minimum effect on the dielectric strength of the sample
Route to Chaos in Optomechanics (2015)

We establish the emergence of chaotic motion in optomechanical systems. Chaos appears at negative detuning for experimentally accessible values of the pump power and other system parameters. We describe the sequence of period-doubling bifurcations that leads to chaos and state the experimentally observable signatures in the optical spectrum. In addition to the semiclassical dynamics, we analyze the possibility of chaotic motion in the quantum regime. We find that quantum mechanics protects the optomechanical system against irregular dynamics, such that simple periodic orbits reappear and replace the classically chaotic motion. In this way observation of the dynamical signatures makes it possible to pin down the crossover from quantum to classical mechanics.
Meta-Analysis of Dilated Cardiomyopathy Using Cardiac RNA-Seq Transcriptomic Datasets (2020)

Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Several studies have used RNA-sequencing (RNA-seq) to profile differentially expressed genes (DEGs) associated with DCM. In this study, we aimed to profile gene expression signatures and identify novel genes associated with DCM through a quantitative meta-analysis of three publicly available RNA-seq studies using human left ventricle tissues from 41 DCM cases and 21 control samples. Our meta-analysis identified 789 DEGs including 581 downregulated and 208 upregulated genes. Several DCM-related genes previously reported, including <i>MYH6</i>, <i>CKM</i>, <i>NKX2-5</i> and <i>ATP2A2</i>, were among the top 50 DEGs. Our meta-analysis also identified 39 new DEGs that were not detected using those individual RNA-seq datasets. Some of those genes, including <i>PTH1R</i>, <i>ADAM15</i> and <i>S100A4</i>, confirmed previous reports of associations with cardiovascular functions. Using DEGs from this meta-analysis, the Ingenuity Pathway Analysis (IPA) identified five activated toxicity pathways, including failure of heart as the most significant pathway. Among the upstream regulators, <i>SMARCA4</i> was downregulated and prioritized by IPA as the top affected upstream regulator for several DCM-related genes. To our knowledge, this study is the first to perform a transcriptomic meta-analysis for clinical DCM using RNA-seq datasets. Overall, our meta-analysis successfully identified a core set of genes associated with DCM.
Evaluation of Traps and Toxicants in an Attract-and-Kill System for Rhagoletis mendax (Diptera: Tephritidae) (2004)

A series of laboratory and field assays were performed to evaluate new methods for an attract-and-kill approach to control blueberry maggot, Rhagoletis mendax Curran. In laboratory assays, fly mortality was similar among insecticide-treated matted paper, plastic, and biodegradable sphere traps. Plastic and biodegradable traps baited with ammonium acetate captured significantly more flies than baited matted paper traps in field assays, whereas fly captures were similar in baited matted paper traps and unbaited plastic sphere traps. Treatments containing imidacloprid resulted in the highest amount of fly knockdown, and spheres coated with this insecticide still had significant knockdown after 6 wk of field exposure. Fly mortality was comparable on sphere traps coated with fipronil and imidacloprid, with both resulting in significantly more fly mortality than the control when flies were exposed to traps that had been weathered for 4 wk in the field. Spheres coated with acetamiprid resulted in fly mortality, but further evaluation is necessary to determine the potential of this compound. Deltamethrin was ineffective in causing fly knockdown at the rate tested. Our results indicate that fipronil and imidacloprid have potential as insecticidal coatings on either plastic or biodegradable spheres in an attract-and-kill system for control of R. mendax.
Bioavailability and tolerability of mebendazole in patients with inoperable hydatid disease (1982)

Journal Article Bioavailability and tolerability of mebendazole in patients with inoperable hydatid disease Get access A.D.M. Bryceson, A.D.M. Bryceson 1Hospital for Tropical Diseases, London NW1 0PE U.K. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Woestenborghs, R. Woestenborghs 2Dept. of Drug Metabolism Janssen Pharmaceutica, B-2340 Beerse, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Michiels, M. Michiels 2Dept. of Drug Metabolism Janssen Pharmaceutica, B-2340 Beerse, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Van Den Bossche H. Van Den Bossche 3Dept. of Comparative Biochemistry, Janssen Pharmaceutica, B-2340 Beerse, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 76, Issue 4, 1982, Pages 563–564, https://doi.org/10.1016/0035-9203(82)90163-8 Published: 01 January 1982 Article history Published: 01 January 1982 Accepted: 26 April 1982
Review on natural language processing tasks for text documents (2014)

This paper mainly focused on Natural Language Processing (NLP) tasks such as Coreference resolution, Discourse Analysis, Named Entity Recognition (NER), Sentiment Analysis, Word sense disambiguation (WSD), Part of Speech (POS), etc. It also reviewed each NLP task with various application areas, with their different approaches and their corresponding methods. This survey is done to decide which NLP task will be better for preprocessing of search keyword, which in turn uses for appropriate matching to desired text documents. Finally it comes to a conclusion that POS tagging and chunking, both will be a better option for preprocessing of keyword, so that its resultant keyword will give desired and important text document.
Serotype-Specific Inactivation of the Cellular DNA Damage Response during Adenovirus Infection (2010)

Adenovirus type 5 (Ad5) inactivates the host cell DNA damage response by facilitating the degradation of Mre11, DNA ligase IV, and p53. In the case of p53, this is achieved through polyubiquitylation by Ad5E1B55K and Ad5E4orf6, which recruit a Cul5-based E3 ubiquitin ligase. Recent evidence indicates that this paradigm does not apply to other adenovirus serotypes, since Ad12, but not Ad5, causes the degradation of TOPBP1 through the action of E4orf6 alone and a Cul2-based E3 ubiquitin ligase. We now have extended these studies to adenovirus groups A to E. While infection by Ad4, Ad5, and Ad12 (groups E, C, and A, respectively) cause the degradation of Mre11, DNA ligase IV, and p53, infection with Ad3, Ad7, Ad9, and Ad11 (groups B1, B1, D, and B2, respectively) only affects DNA ligase IV levels. Indeed, Ad3, Ad7, and Ad11 cause the marked accumulation of p53. Despite this, MDM2 levels were very low following infection with all of the viruses examined here, regardless of whether they increase p53 expression. In addition, we found that only Ad12 causes the degradation of TOPBP1, and, like Ad5, Ad4 recruits a Cul5-based E3 ubiquitin ligase to degrade p53. Surprisingly, Mre11 and DNA ligase IV degradation do not appear to be significantly affected in Ad4-, Ad5-, or Ad12-infected cells depleted of Cul2 or Cul5, indicating that E1B55K and E4orf6 recruit multiple ubiquitin ligases to target cellular proteins. Finally, although Mre11 is not degraded by Ad3, Ad7, Ad9, and Ad11, no viral DNA concatemers could be detected. We suggest that group B and D adenoviruses have evolved mechanisms based on the loss of DNA ligase IV and perhaps other unknown molecules to disable the host cell DNA damage response to promote viral replication.
Differential Video Noise Estimation (2006)

In this paper, we propose a fast and reliable white- noise variance estimation. The method subtracts two sequential frames of video first and then finds intensity-homogeneous blocks in both original image and differential image, and at last estimates the noise variance in these blocks by a Gaussian weighted averaging process. Experiments show that the proposed method performs well both in highly noisy and good- quality images. It also works well in videos including rich motion, large textured areas and few uniform blocks.
Existence dependency: The key to semantic integrity between structural and behavioral aspects of object types (1998)

In object-oriented conceptual modeling, the generalization/specialization hierarchy and the whole/part relationship are prevalent classification schemes for object types. This paper presents an object-oriented conceptual model where, in the end, object types are classified according to two relationships only. Existence dependency and generalization/specialization. Existence dependency captures some of the interesting semantics that are usually associated with the concept of aggregation (also called composition or Part Of relation), but in contrast with the latter concept, the semantics of existence dependency are very precise and its use clear cut. The key advantage of classifying object types according to existence dependency are the simplicity of the concept, its absolute unambiguity, and the fact that it enables to check conceptual schemes for semantic integrity and consistency. We will first define the notion of existence dependency and claim that it is always possible to classify objects according to this relationship, thus removing the necessity for the Part Of relation and other kinds of associations between object types. The second claim of this paper is that existence dependency is the key to semantic integrity checking to a level unknown to current object-oriented analysis methods. In other words: Existence dependency allows us to track and solve inconsistencies in an object-oriented conceptual schema.
Shipping and Freight Rates in the Overseas Grain Trade (1938)

Crop Production/Industries, International Relations/Trade
Developing Undergraduate Entrepreneurial Abilities using Problem Based Learning (2001)

This article describes a pilot programme, organised by the Employability Unit, that took place over two weeks at the University of North London. The programme involved cross-disciplinary groups of undergraduates (from Electronics and Business Studies) producing innovative solutions to problems identified by SMEs in the Performing Arts Technology sector. Students researched the issues and developed possible solutions that were recorded in videoed oral presentations and in written reports; a copy of the latter was provided to each SME. The operational processes are outlined and the results of the evaluation are given. Some of the students opted to have their work assessed and accredited through an advanced level professional placement module. This article describes the pilot programme, which could be adapted for the GEES disciplines.
Biochemical and pharmacological evaluation of the novel antidepressant and serotonin uptake inhibitor 2-(3,4-Dichlorobenzyl)-2-dimethylamino-1-propanol hydrochloride. (1990)

2-(3,4-Dichlorobenzyl)-2-dimethylamino-1-propanol, hydrochloride (JO 1017) is a novel antidepressant drug. Its biochemical and pharmacological properties were investigated in mice, rats, dogs, rabbits and guinea pigs. In vitro, it selectively inhibited serotonin uptake and had a high affinity for the 3H-paroxetine and 3H-imipramine binding sites. Biochemical studies demonstrated the lack of MAO-A and MAO-B inhibition and the absence of marked affinity for muscarinic, histaminic or other conventional brain receptors. Chronic treatment with JO 1017 induced a decrease in the Bmax values for imipramine sites but did not modify the Bmax for beta-adrenergic and 5-HT2 receptors. The neuropsychopharmacological profile of JO 1017 is characterized by a decrease of the immobility times in behavioural despair tests with mice, a decrease of the escape failures in the rat learned helplessness test, a strong potentiation of L-5-HT P-induced head-twitches in mice and an antagonism of reserpine-induced ptosis in rabbits. It weakly antagonized oxotremorine-induced hypothermia and did not influence the hypothermia induced by apomorphine. In contrast to most other antidepressants, a high dose of JO 1017 induced hypermotility in mice placed in an activity meter without producing stereotyped behaviour and group toxicity. Unlike tricyclic antidepressants, JO 1017 was devoid of severe cardiotoxicity in guinea pigs and had no central anticholinergic nor antihistaminic properties. These results suggest that JO 1017 is a selective serotonin uptake inhibitor with a high safety margin. JO 1017 may have a potential clinical utility both in the treatment of depression and for indications where serotonin transmission is involved, e.g., anxiety, panic attack, obsessive compulsive disorder, obesity and alcohol consumption.
Precipitation of Calcium Hydrogen Orthophosphate. Four-Variable Statistical Design (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPrecipitation of Calcium Hydrogen Orthophosphate. Four-Variable Statistical DesignA. J. Comstock, S. J. Jurnack, and R. W. MooneyCite this: Ind. Eng. Chem. 1959, 51, 3, 325–328Publication Date (Print):March 1, 1959Publication History Published online1 May 2002Published inissue 1 March 1959https://pubs.acs.org/doi/10.1021/ie51394a048https://doi.org/10.1021/ie51394a048research-articleACS PublicationsRequest reuse permissionsArticle Views25Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
[Detection of cytomegalovirus in urine specimens from renal transplant recipients using polymerase chain reaction]. (1992)

Human cytomegalovirus (CMV) in this study, a polymerase chain reaction (PCR) assay was developed to detect human cytomegalovirus (CMV) from urine specimens taken from renal transplant patients and one congenital CMV infection. Twenty eight urine specimens of 20 renal transplant patients were analyzed by the PCR. CMV infection was detected in 11 specimens (8 recipients). The incidence (40.0%) of PCR positive in the renal transplant patients was highest among the other conventional methods including fluorescent antibody study, anti-IgM EIA and complement fixation test. In two cases, CMV infection could be identified by PCR before antibody development. The PCR procedure is more sensitive and rapid than conventional methods for the diagnosis of CMV. Rapid diagnosis of CMV infection using PCR may be useful in clinical diagnosis and have therapeutic value.
Ownership of Bibliographic Data and Its Importance to Consortia (1988)

No abstract available for this article.
Excimer fluorescence for plasma displays (1982)

Experimental tests confirm analytical predictions that usefully bright excimer fluorescence in the visible region can be produced under discharge conditions achievable in conventional ac plasma panel configurations. Results are presented for the Xe2Cl excimer exhibiting broadband blue emission peaked at 476 nm.