gebhart/patrepeval huggingface dataset:
Reproductive Performances of Crossbred and Pure-Strain Channel Catfish Brood Stocks (1983)

Pure-strain and interstrain (crossbred) channel catfish Ictalurus punctatus were compared for spawning day, spawning rate (percent of replicate pairs that spawned), fecundity, egg size and hatchability, and survival of offspring. Crossbred fish usually spawned earlier (P < 0.05) than pure-strain channel catfish. As 3-year-olds, crossbred fish had higher spawning rates and fecundity than purebred fish, and their output of juveniles (number surviving 45 days in ponds, per kilogram of female parent) was greater. As 4-year-olds, pure-strain fish improved their performances, and crossbreds lost most of their relative advantages. Brood stock derived from crosses of four strains spawned earlier than those from two-strain F2 crosses, but their surviving offspring were no more numerous. The main value of cross-strain breeding is to produce channel catfish that mature earlier in life and spawn sooner in the season than purebreds. Received July 16, 1982 Accepted March 4, 1983
Ultrastructural Evidence of Dermal Gadolinium Deposits in a Patient with Nephrogenic Systemic Fibrosis and End-Stage Renal Disease (2008)

These findings support the pivotal role of gadolinium chelates in the development of nephrogenic systemic fibrosis.
A multidrug resistance plasmid contains the molecular switch for type VI secretion in <i>Acinetobacter baumannii</i> (2015)

Infections with Acinetobacter baumannii, one of the most troublesome and least studied multidrug-resistant superbugs, are increasing at alarming rates. A. baumannii encodes a type VI secretion system (T6SS), an antibacterial apparatus of Gram-negative bacteria used to kill competitors. Expression of the T6SS varies among different strains of A. baumannii, for which the regulatory mechanisms are unknown. Here, we show that several multidrug-resistant strains of A. baumannii harbor a large, self-transmissible resistance plasmid that carries the negative regulators for T6SS. T6SS activity is silenced in plasmid-containing, antibiotic-resistant cells, while part of the population undergoes frequent plasmid loss and activation of the T6SS. This activation results in T6SS-mediated killing of competing bacteria but renders A. baumannii susceptible to antibiotics. Our data show that a plasmid that has evolved to harbor antibiotic resistance genes plays a role in the differentiation of cells specialized in the elimination of competing bacteria.
Investigation of statistical techniques to select optimal test levels for spacecraft vibration tests Final report, 1 Nov. 1969 - 31 Oct. 1970 (1970)

Statistical techniques for selecting optimal test levels for vibration tests of spacecraft hardware
Novel approach for modifying microporous filters for virus concentration from water. (1988)

Electronegative microporous filters composed of epoxyfiberglass (Filterite) were treated with cationic polymers to enhance their virus-adsorbing properties. This novel and inexpensive approach to microporous filter modification entails soaking filters in an aqueous solution of a cationic polymer such as polyethyleneimine (PEI) for 2 h at room temperature and then allowing the filters to air dry overnight on absorbent paper towels. PEI-treated filters were evaluated for coliphage (MS2, T2, and phi X174) and enterovirus (poliovirus type 1 and coxsackievirus type B5) adsorption from buffer at pH 3.5 to 9.0 and for indigenous coliphages from unchlorinated secondary effluent at ambient pH. Adsorbed viruses were recovered with 3% beef extract (pH 9). Several other cationic polymers were used to modify epoxyfiberglass filters and were evaluated for their ability to concentrate viruses from water. Zeta potentials of disrupted filter material indicated that electronegative epoxyfiberglass filters were made more electropositive when treated with cationic polymers. In general, epoxyfiberglass filters treated with cationic polymers were found to adsorb a greater percentage of coliphages and enteroviruses than were untreated filters.
Clinical, biomechanical and biological aspects of immediately loaded dental implants: a critical review of the literature (2010)

In recent years, the use of immediately loaded implants became more acceptable as a standard protocol for completely edentulous lower jaw and/or partially edentulous upper jaw cases, predominantly in the anterior region, after it was one of the cornerstones of the early protocols to avoid any occlusal loading of the implants for at least 3 months. This technique could potentially provide immediate function and aesthetics to the patient. This review aims to present the clinical indications of the immediately loaded protocol according to the individual cases and the corresponding risk factors and contraindications. The clinical, biomechanical and biological requirements concerning bone quality, occlusal loading and implant primary stability are discussed. Primary stability in immediate loading is determined rather by surgical than biological parameters. Peri-implant osteogenesis leading to secondary stability depends on the same biological factors than in unloaded implant healing. However, specific mechanical effects on the biology of immediate loading osseointegration are yet to be investigated.
Control of Rapid Phase Transition Induced by Supramolecular Complexation of β-Cyclodextrin-Conjugated Poly(ε-lysine) with a Specific Guest (2003)

β-Cyclodextrin-conjugated poly(ε-lysine) (β-CDPL) was synthesized and used as a polymeric host for inclusion complexation with 3-trimethylsilylpropionic acid (TPA). The specific host−guest interaction was analyzed by electrospray ionization mass and X-ray diffraction spectroscopies. In this system, TPA included into the hydrophobic cyclodextrin cavity acted as a physical cross-linker by cooperative hydrophobic and ionic interactions, which gave an important role in viscosity or transmittance changes near physiological conditions. The pronounced effect of pH on the change of viscosity was supported by rheological data. On the other hand, reversible phase transitions of the supramolecular assembling system occurred very rapidly in response to minute changes of temperature, which was verified by UV−vis measurements. The delicate control of critical aggregation temperature was accomplished by changing the degree of substitution as well as varying molar feed ratio or solution concentrations across their upper critical solution temperature. This rapid and elaborate supramolecular assembling system is promising as smart materials and can find a broad range of applications.
Word level automatic alignment of music and lyrics using vocal synthesis (2010)

We propose a signal-based approach instead of the commonly used model-based approach, to automatically align vocal music with text lyrics at the word level. In this approach, we use a text-to-speech system to synthesize the singing voice according to the lyrics. In this way, aligning the music signal with the corresponding text lyrics becomes the alignment of two audio signals. This study uses the results of music information modeling and singing voice synthesis. In music information modeling, we study different music representation strategies for music segmentation, music region indexing and region content descriptions; in singing voice synthesis, we generate singing voice by making use of music knowledge to approximate the target vocal line in terms of tempo. The experimental results on a 20-song database show 26.3% and 36.1% word level alignment error rates at eighth note and sixteenth note alignment tolerances respectively. The proposed approach presents an alternative and effective solution to music-lyrics alignment which may require less training dataset.
Bonding of Phosphinidene or Arsenidene Fragments to a Fluorenylidene. Interrelationships between Phosphaalkenes or Arsaalkenes and Donor−Acceptor Complexes (1997)

The fluorenylidene-substituted phosphaalkene MesP=Fl (13) and arsaalkene MesAs=Fl (14) (Mes = 2,4,6-t-Bu(3)C(6)H(2), Fl = 2,7-di-tert-butylfluorenylidene) have been prepared by treatment of Fl(H)Li with MesECl(2) (E = P, As) followed by dehydrochlorination with DABCO (1,4-diazabicyclo[2.2.2]octane). In the synthesis of 13 it was possible to isolate the intermediate, Mes(Cl)P-(H)Fl (11). Attempts to prepare the stibaalkene, MesSb=Fl (15), resulted in an unstable product. Compounds 11, 13, and 14 were characterized by X-ray crystallography: 11, triclinic, P&onemacr;, a = 11.548(2) Å, b = 12.189(3) Å, c = 14.223(3) Å, alpha = 114.13(1) degrees, beta = 92.79(1) degrees, gamma = 107.14(1) degrees, V = 1712.8(2) Å(3), Z = 2, wR2 = 0.1344, R1 = 0.0560; 13, monoclinic, P2(1)/n, a = 24.597(7) Å, b = 11.185(2) Å, c = 26.914(7) Å, beta = 112.16(2) degrees, V = 6857(3) Å(3), Z = 8, wR2()()= 0.1477, R1 = 0.0794; 14.Et(2)O, monoclinic, P2(1)/n, a = 15.577(4) Å, b = 15.274(4) Å, c = 17.255(5) Å, beta = 108.17(2) degrees, V= 3901(2) Å(3), Z = 4, wR2()()= 0.1275, R1 = 0.0578. The P=C (1.686(5) Å) and As=C (1.807(3) Å) bond distances in 13 and 14 are consistent with double-bonding descriptions; moreover, there is a zero angle of twist between the E-C(Mes) moieties and the plane of the Fl() ligand in both molecules.
Coherent dynamics of Rydberg atoms in cosmic-microwave-background radiation (2014)

Rydberg atoms excited by cold blackbody radiation are shown to display long-lived quantum coherences on time scales of tens of picoseconds. By solving non-Markovian equations of motion with no free parameters we obtain the time evolution of the density matrix and demonstrate that the blackbody-induced temporal coherences manifest as slowly decaying (100 ps) quantum beats in time-resolved fluorescence. An analytic model shows the dependence of the coherent dynamics on the energy splitting between atomic eigenstates, transition dipole moments, and coherence time of the radiation. Experimental detection of the fluorescence signal from a trapped ensemble of ${10}^{8}$ Rydberg atoms is discussed, but shown to be technically challenging at present, requiring cosmic-microwave-background amplification somewhat beyond current practice.
Interpolation revisited [medical images application] (2000)

Based on the theory of approximation, this paper presents a unified analysis of interpolation and resampling techniques. An important issue is the choice of adequate basis functions. We show that, contrary to the common belief, those that perform best are not interpolating. By opposition to traditional interpolation, we call their use generalized interpolation; they involve a prefiltering step when correctly applied. We explain why the approximation order inherent in any basis function is important to limit interpolation artifacts. The decomposition theorem states that any basis function endowed with approximation order can be expressed as the convolution of a B-spline of the same order with another function that has none. This motivates the use of splines and spline-based functions as a tunable way to keep artifacts in check without any significant cost penalty. We discuss implementation and performance issues, and we provide experimental evidence to support our claims.
Location of the radioactive heat sources uranium and thorium in the Earth's lower mantle. (2007)

International audience
Effects of process errors on the diffraction characteristics of binary dielectric gratings (1995)

The effects of fabrication errors on the predicted performance of surface-relief phase gratings are analyzed with a rigorous vector diffraction technique. For binary elements, errors in the dimensions of the profile [depth, linewidth (fill factor), and grating period], as well as errors in the shape of the profile, are investigated. It is shown that the dimension errors do not have a significant effect on grating performance when the grating is designed for either maximum or minimum diffraction efficiency. A trapezoid is used to model the shape error of the profile. For the first time, design rules that significantly reduce the effects of any shape error are presented.
A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events (2017)

Our results are consistent with the accumulating body of evidence that herpes zoster and herpes zoster ophthalmicus are significantly associated with cerebrovascular and cardiovascular events.
Remembered and Recovered: Bethune and the Canadian Blood Transfusion Unit in Málaga, 1937 (1995)

Arthroscopy of the hip is a valuable diagnostic and therapeutic procedure for patients with hip pain refractory to conservative therapy.
Design and modification of three-component randomly incorporated copolymers for high performance organic photovoltaic applications (2012)

In this study we report the molecular design, synthesis, characterization, and photovoltaic properties of a series of diketopyrrolopyrrole (DPP) and dithienothiophene (DTT) based donor–acceptor random copolymers. The six random copolymers are obtained via Stille coupling polymerization using various concentration ratios of donor to acceptor in the conjugated backbone. Bis(trimethylstannyl)thiophene was used as the bridge block to link randomly with the two comonomers 5-(bromothien-2-yl)-2,5-dialkylpyrrolo[3,4-c]pyrrole-1,4-dione and 2,6-dibromo-3,5-dipentadecyl-dithieno[3,2-b;2′,3′-d]thiophene. The optical properties of these copolymers clearly reveal a change in the absorption band through optimization of the donor–acceptor ratio in the backbone. Additionally, the solution processability of the copolymers is modified through the attachment of different bulky alkyl chains to the lactam N-atoms of the DPP moiety. Applications of the polymers as light-harvesting and electron-donating materials in solar cells, in conjunction with PCBM as acceptor, show power conversion efficiencies (PCEs) of up to 5.02%.
An expandable intravenous RF coil for arterial wall imaging (1998)

An intravenous (iv) radiofrequency (RF) coil is proposed as a means of obtaining high resolution images of artery wall. The anatomic positioning of peripheral artery/vein pairs was investigated and a phantom mimicking the iliac artery/vein pair was constructed. Imaging results, comparing iv coils with external coils, demonstrated a potential 15- to 20-fold increase in signal-to-noise ratio (SNR) with iv coils. The SNR benefit was measured over a cylindrical volume, adjacent to the coil, and typical of artery position. Prototype expandable iv coils were constructed of Cu-Be loops and introduced via an 8-Fr catheter. The effects of local and remote iv coil tuning were investigated and local tuning was found to provide significant SNR benefits. The in vivo performance of iv RF coils was demonstrated in a porcine animal model. The iv coils were found to be an excellent alternative to intraarterial coils.
ChemInform Abstract: AN EPR STUDY OF RARE‐EARTH IMPURITIES IN SINGLE CRYSTALS OF THE ZIRCON‐STRUCTURE ORTHOPHOSPHATES: SCANDIUM PHOSPHATE, YTTRIUM PHOSPHATE, AND LUTETIUM PHOSPHATE (1983)

Abstract Da verbrauchte Kernreaktor‐Brennstoffe bis zu 35 Gew.‐% Seltenerdmetall‐Oxide (SE‐Oxide) hoher Radioaktivität enthalten, kommen die chemisch und physikalisch sehr stabilen SE‐Orthophosphate für die Deponierung dieser Abfälle in Betracht.
Anatomy of the Clavicle and Coracoid Process for Reconstruction of the Coracoclavicular Ligaments (2007)

Clavicle length can be obtained intraoperatively. These findings allow the surgeon to predict the origin of the conoid and trapezoid ligaments accurately and to correctly create bone tunnels to reconstruct the anatomy of the CC complex.
Reframing Threat Detection: Inside esINSIDER (2019)

We describe the motivation and design for esINSIDER, an automated tool that detects potential persistent and insider threats in a network. esINSIDER aggregates clues from log data, over extended time periods, and proposes a small number of cases for human experts to review. The proposed cases package together related information so the analyst can see a bigger picture of what is happening, and their evidence includes internal network activity resembling reconnaissance and data collection. The core ideas are to 1) detect fundamental campaign behaviors by following data movements over extended time periods, 2) link together behaviors associated with different meta-goals, and 3) use machine learning to understand what activities are expected and consistent for each individual network. We call this approach campaign analytics because it focuses on the threat actor's campaign goals and the intrinsic steps to achieve them. Linking different campaign behaviors (internal reconnaissance, collection, exfiltration) reduces false positives from business-as-usual activities and creates opportunities to detect threats before a large exfiltration occurs. Machine learning makes it practical to deploy this approach by reducing the amount of tuning needed.
Regulation of CovR expression in Group B Streptococcus impacts blood–brain barrier penetration (2010)

Group B Streptococcus (GBS) is an important cause of invasive infections in humans. The pathogen encodes a number of virulence factors including the pluripotent beta-haemolysin/cytolysin (beta-H/C). As GBS has the disposition of both a commensal organism and an invasive pathogen, it is important for the organism to appropriately regulate beta-H/C and other virulence factors in response to the environment. GBS can repress transcription of beta-H/C using the two-component system, CovR/CovS. Recently, we described that the serine/threonine kinase Stk1 can phosphorylate CovR at threonine 65 to relieve repression of beta-H/C. In this study, we show that infection with CovR-deficient GBS strains resulted in increased sepsis. Although CovR-deficient GBS showed decreased ability to invade the brain endothelium in vitro, they were more proficient in induction of permeability and pro-inflammatory signalling pathways in brain endothelium and penetration of the blood-brain barrier (BBB) in vivo. Microarray analysis revealed that CovR positively regulates its own expression and regulates the expression of 153 genes. Collectively, our results suggest that the positive feedback loop which regulates CovR transcription modulates host cell interaction and immune defence and may facilitate the transition of GBS from a commensal organism to a virulent meningeal pathogen.
Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands (2009)

The importance of Notch signaling to maintain CD8- dendritic cells (DCs) in the spleen has recently been revealed. However, the ligand responsible for this Notch signaling has not been determined yet. In this study, we demonstrated that blocking of Delta-like (Dll) 1 alone had no significant effect on the maintenance of CD8- DCs while marginal zone (MZ) B cells were significantly reduced in the spleen of mice. On the other hand, blocking of Dll1, Dll4, Jagged1 and Jagged2 significantly decreased CD8- DCs. All these Notch ligands are expressed predominantly in the red pulp of the spleen where CD8- DCs reside. These results indicate a differential regulation of CD8- DCs and MZ B cells by Notch ligands in the spleen.
Interleukin-2 therapy in patients with metastatic malignant melanoma: a phase II study. (1990)

Forty-seven patients with metastatic malignant melanoma were treated with two 5-day cycles of 100,000 U/kg recombinant interleukin-2 (IL-2) intravenously (IV) every 4 hours separated by 1 week. This dose and schedule of IL-2 were identical to those used in a previous combined IL-2 and lymphokine-activated killer (LAK) cell phase II clinical trial of the IL-2/LAK Working Group. Patient eligibility criteria, and clinical management guidelines were similar to those used in the previous trial. Forty-six patients were assessable for response. Objective responses were observed in 10 of 46 patients (two complete responses [CRs], eight partial responses [PRs]) or 22% with responses occurring in lung and liver as well as lymph nodes and subcutaneous sites. The median response duration was 8 months. Toxicity was significant; three patients developed myocardial infarction, and one patient died during therapy. Overall the toxicity and response rate for single-agent IL-2 are similar to that observed with IL-2 administered in combination with LAK cells in the previous trial. These results suggest that single-agent therapy with IL-2 when administered in this schedule has significant antimelanoma activity in humans, and that LAK cells generated from peripheral blood add little to the antimelanoma activity of this dose and schedule of IL-2.
Advanced TIL system for laser beam focusing in a turbulent regime (2014)

This paper discusses an advanced target in the loop (ATIL) system with its performance based on a nonlinear phase conjugation scheme that performs rapid adjustment of the laser beam wavefront to mitigate effects associated with atmospheric turbulence along the propagation path. The ATIL method allows positional control of the laser spot (the beacon) on a remote imaged-resolved target. The size of this beacon is governed by the reciprocity of two counterpropagating beams (one towards the target and another scattered by the target) and the fidelity of the phase conjugation scheme. In this presentation we will present the results of the thorough analysis of ATIL operation, factors that affect its performance, its focusing efficiency and the comparison of laboratory experimental validation and computer simulation results.
Forces in Swimming Two Types of Crawl Stroke (1955)

Abstract In this study the resistive and propulsive forces of three swimmers swimming two types of crawl stroke—the glide stroke and the continuous stroke—were measured. An apparatus was constructed which utilized strain gauges to measure these forces. It was found that the continuous stroke was faster than the glide stroke and created more propulsive force with less fluctuation in the application of the force.
The NPK1 mitogen‐activated protein kinase kinase kinase contains a functional nuclear localization signal at the binding site for the NACK1 kinesin‐like protein (2002)

The tobacco mitogen-activated protein kinase kinase kinase NPK1 localizes to the equatorial region of phragmoplasts by interacting with kinesin-like protein NACK1. This leads to activation of NPK1 kinase at late M phase, which is necessary for cell plate formation. Until now, its localization during interphase has not been reported. We investigated the subcellular localization of NPK1 in tobacco-cultured BY-2 cells at interphase using indirect immunofluorescence microscopy and fusion to green fluorescent protein (GFP). Fluorescence of anti-NPK1 antibodies and GFP-fused NPK1 were detected only in the nuclei of BY-2 cells at interphase. Examination of the amino acid sequence of NPK1 showed that at the carboxyl-terminal region in the regulatory domain, which contains the binding site of NACK1, NPK1 contained a cluster of basic amino acids that resemble a bipartite nuclear localization signal (NLS). Amino acid substitution mutations in the critical residues in putative NLS caused a marked reduction in nuclear localization of NPK1 in BY-2 cells, indicating that this sequence is functional in tobacco BY-2 cells. We also found that the 64-amino acid sequence at the carboxyl terminus that contains NLS sequence is essential for interaction with NACK1, and that mutations in the NLS sequence prevented NPK1 from interacting with NACK1. Thus, the amino acid sequence at the carboxyl-terminal region of NPK1 has dual functions for nuclear localization during interphase and binding NACK1 in M phase.