gebhart/patrepeval huggingface dataset:
Mechanism-based biomarkers of activity for a novel HDAC inhibitor PCI-24781 in solid and hematologic malignancies (2007)

C24 Broad-spectrum histone deacetylase (HDAC) inhibitors are currently showing promise in clinical trials for treating a variety of neoplastic malignancies. One such compound, PCI-24781, is a novel, orally bioavailable HDAC inhibitor that effectively inhibits the enzymatic activity of most of the eleven known HDAC isoforms. PCI-24781 is active against many tumors in preclinical models including cell lines, mouse xenograft models and in primary human tumors cultured ex vivo with mean GI50 values of 0.1 -0.5 uM, depending on tumor type. One of the mechanisms of activity of this compound involves inhibition of DNA repair pathways. When samples from these experiments were examined by a combination of whole genome expression profiling, Western blotting for key proteins, and biochemical pathway analysis, we found a correlation between activity and expression changes in several key DNA repair genes, including RAD51. This protein is essential for DNA repair by homologous recombination (HR), and interestingly, we found that PCI-24781 can synergize with poly (ADP-ribose) polymerase (PARP) inhibitor PJ34, an agent thought to produce lesions repaired by HR. Further, we found that RAD51 is downregulated at both protein and mRNA levels by PCI-24781 in both solid and hematopoietic cell lines and tumors, leading to inhibition of DNA repair and RAD51 foci formation, eventually leading to apoptosis. The decrease in RAD51 levels upon PCI-24781 treatment showed a significant correlation with activity in these models. When the differences between sensitive and resistant tumors were analyzed, it was observed that sensitive tumors showed a consistent decrease of >2-fold in RAD51 levels, whereas resistant tumors did not. Thus, RAD51 appears to be a good biomarker of sensitivity in both solid and hematologic tumors. In addition, from the primary colon tumors, we have also identified a set of genes previously associated with chemoresistance that were expressed at 3-15 fold higher levels in the resistant tumors. This signature was confirmed by Taqman (RT-PCR) analysis, and was further validated in an independent set of primary colon tumors. These markers of sensitivity and resistance will be used to identify likely responders in clinical trials with PCI-24781.
Curve representing and matching based on feature points and minimal area threshold (2009)

A new method for representing and recognizing the contour curve is presented in this paper. First, feature points are employed to describe contour curve preliminarily; Then the sample points of the sub-curve are introduced to describe contour more, they are obtained based on the precision requirement using the given minimal area threshold. A new recognition vector of sample points is defined, and a novel recognition vector matrix is constructed based on the recognition vector of sample points; Last the dissimilarity measure of the corresponding sub-curves is calculated by compared the recognition vector matrix. The curves are recognized by recognizing their each sub-curve. The method match object and model from simple to complex, thus many redundancies calculation are avoided. The experiment results show the algorithm is efficient and feasible.
Possible method to observe the breathing mode of a magnetic domain wall in the Josephson junction (2014)

A magnetic domain wall (DW) behaves as a massive particle with elasticity. Sliding and oscillation of the DW have been observed experimentally, whereas vibration of a width in the DW, "breathing mode", has not been measured so far. We theoretically propose how to observe the breathing mode by the Josephson junction having a ferromagnetic layer between superconducting electrodes. The current-voltage (I-V) curve is calculated by an equivalent circuit of the resistively shunted junction model. The breathing mode is identified by stepwise structures in the I-V curve, which appear at the voltages V=n(hbar/2e)omega with the fundamental constant hbar/e, integer number n, and the frequency of the breathing mode omega.
Reactions of Zirconocene 2-Vinylpyridine Complexes with Diisobutylaluminum Hydride and Fluoride (2004)

In reactions of the zirconocene 2-vinylpyridine complex Cp2Zr(2-vipy) (1) with iBu2AlH and iBu2AlF the isostructural complexes [Cp2Zr(μ-η1:η2-2-CH2CH−C5H4N)(μ-H)][iBu2Al] (3) and [Cp2Zr(μ-η1:η2-2-CH2CH−C5H4N)(μ-F)][iBu2Al] (5) were formed. These complexes can serve as models for the transfer of fluorine from zirconium to aluminum (Zr−F with Al−H to Zr−H and Al−F) found in the reaction of rac-(ebthi)ZrF2 with iBu2AlH to form the dimeric complex [rac-(ebthi)ZrH(μ-H)]2 (6). The compounds are important in obtaining an understanding of the activation of zirconocene fluoro complexes by iBu3Al and of the role of iBu2AlH in activation processes for the catalytic polymerization of olefins.
Differential Effects of Human Immunodeficiency Virus Isolates on β-Chemokine and Gamma Interferon Production and on Cell Proliferation (1999)

All human immunodeficiency virus (HIV) isolates can grow readily in primary CD4(+) T cells, but they can be distinguished by their ability to replicate in macrophages and established T-cell lines. The macrophage-tropic viruses are generally non-syncytium inducing (NSI), whereas the T-cell-line-tropic viruses are syncytium inducing (SI) in cultured cells. We now demonstrate that infection of CD4(+) T cells by NSI and SI viruses shows a differential effect on production of beta-chemokines and gamma interferon. Infection by NSI viruses increased production of MIP-1alpha, MIP-1beta, and gamma interferon, whereas infection by SI viruses had no effect or decreased production of these cytokines. Production of RANTES was slightly increased during infection by both virus phenotypes. This differential effect of NSI and SI viruses was observed at the level of beta-chemokine mRNA as well as at the level of protein expression. Infection by NSI viruses also increased CD4(+) cell proliferation. These results may have relevance for a differential role of HIV strains in AIDS pathogenesis.
Carta de José Navarro Mas acompañando un ejemplar de su memoria sobre las viñas. Dicho ejemplar no aparece. (1805)

Carta de José Navarro Mas acompañando un ejemplar de su memoria sobre las viñas. Dicho ejemplar no aparece.
Preparation, Crystal Structure and High-Temperature Thermoelectric Properties of Double Perovskite-Type Rare-Earth Cobalt Ruthenium Oxides (2007)

Rare-earth cobalt ruthenium oxides Ln2CoRuO6 (Ln=La, Pr, Nd, Sm, Eu and Gd) having the double perovskite-type structure were prepared at 1673 K in air. Rietveld analysis of the X-ray diffraction patterns revealed that the oxides crystallized in monoclinic cells with space group P21/n (No. 14). Co/Ru disorder up to 10% was observed at each of the octahedral site in GdCoRuO6. Ln2CoRuO6 oxides were p-type semiconductors with Seebeck coefficient of 180-290 μV·K-1 at 400 K and 72-79 μV·K-1 at 1073 K. The power factors at 1073 K were 1.9-4.3×10-6 W·K-2·m-1.
Statistical characteristics of aberrations of human eyes after small incision lenticule extraction surgery and analysis of visual performance with individual eye model (2015)

Preoperative and postoperative wavefront aberrations of 73 myopic eyes with small incision lenticule extraction surgery are analyzed in this paper. Twenty-eight postoperative individual eye models are constructed to investigate the visual acuity (VA) of human eyes. Results show that in photopic condition, residual defocus, residual astigmatism, and higher-order aberrations are relatively small. 100% of eyes reach a VA of 0.8 or better, and 89.3% of eyes reach a VA of 1.0 or better. In scotopic condition, the residual defocus and the higher-order aberrations are, respectively, 1.9 and 8.5 times the amount of that in photopic condition, and the defocus becomes the main factor attenuating visual performance.
Non‐invasive biological quantification of acute gastrointestinal graft‐versus‐host disease in children by plasma citrulline (2013)

Clinical grading of GI involvement during acute GVHD remains a challenging issue, especially in children. Plasma citrulline, a non-protein amino acid selectively produced and released by enterocytes, is a suitable surrogate endpoint for small intestinal epithelial cell mass, irrespective of the underlying cause of cell loss. Children referred for allogeneic bone marrow transplantation who were free from chronic malabsorption or constitutional disease involving the GI tract were consecutively included in this prospective study. Plasma citrulline and albumin concentration was measured every week between day 7 and day 28 of BMT until resolution of the aGVHD or occurrence of chronic GVHD. In total, 31 children were included between 2008 and 2011. After a CR, citrulline levels fell to a minimum level on day 7 and then increased to reach the initial value on day 28. After day 28, plasma citrulline but not albumin was strongly linked to the occurrence of GI GVHD, the threshold being set at 10 μmol/L. The correlation with clinical grade of GI-aGVHD now needs to be assessed in larger populations. In pediatric patients, citrulline is valuable as a suitable non-invasive marker of GI involvement in acute GVHD.
Fiber coating with surfactant solutions (2002)

When a fiber is withdrawn at low speeds from a pure fluid, the variation in the thickness of the entrained film with imposed fiber velocity is well-predicted by the Landau–Levich–Derjaguin (LLD) equation. However, surfactant additives are known to alter this response. We study the film thickening properties of the protein BSA (bovine serum albumin), the nonionic surfactant Triton X-100, and the anionic surfactant SDS (sodium dodecyl sulfate). For each of these additives, the film thickening factor α (the ratio of the measured thickness to the LLD prediction) for a fixed fiber radius varies as a function of the ratio of the surfactant concentration c to the critical micelle concentration (CMC). In the case of BSA, which does not form micelles, the reference value is the concentration at which multilayers form. As a result of Marangoni effects, α reaches a maximum as c approaches the CMC from below. However, when the surfactant concentration c exceeds the CMC, the behavior of α varies as a consequence of the dynamic surface properties, owing for example to different sorption kinetics of these additives, or possibly surface or bulk rheological effects. For SDS, α begins to decrease when c exceeds the CMC and causes the surface to become partially or completely remobilized, which is consistent with the experimental and theoretical results published for studies of slug flows of bubbles and surfactant solutions in a capillary tube and the rise of bubbles in surfactant solutions. However, when the SDS or Triton X-100 surfactant concentration is well above the CMC, we observe that the film thickening parameter α increases once again. In the case of SDS we observe a second maximum in the film thickening factor. For all the experiments, transport of monomers to the interface is limited by diffusion and the second maximum in the film thickening factor may be explained as a result of a nonmonotonic change in the stability characteristics of suspended SDS micelles and corresponding changes in the rheology of the solution.
A 2D artificial metamaterial made from anisotropically conducting strips (2011)

A 2D electrodynamic structure formed as a small-period lattice of anisotropically conducting strips located in parallel planes is considered. For the case of the TE polarization, the effective constitutive parameters of the structure are calculated. It is shown that the permittivity of the metamaterial is negative and that, near the resonance frequency of a single strip, there is a transparency band where the diagonal elements of the permeability tensor have opposite signs.
Adaptive low complexity algorithm for image zooming at fractional scaling ratio (2002)

Interpolation of images to higher resolution is an important feature in many digital imaging applications ranging from image zooming for digital camera to image zooming in digital video. Practical digital imaging applications require the ability to scale an image in any fractional ratio, under low complexity/memory restrictions. Many traditional zooming algorithms are restricted to integer zooming ratios and yield poor results in edgy areas of the image; some are even restricted to powers-of-two ratios. Algorithms that achieve high quality are usually too complex to be implemented in low complexity/memory environments like VLSI. We present a new adaptive algorithm for image zooming, suitable for fractional zooming ratios, motivated by the work of Ting et al. (1996). The new algorithm performs better than known algorithms on a variety of images at both integer and fractional zooming ratios and is better suited for VLSI implementation.
HYBRID TIME AND FREQUENCY DOMAIN TECHNIQUE ON MODAL IDENTIFICATION USING AMBIENT VIBRATION TESTS (2009)

In this paper, in order to identify the modal properties of a structure based on the ambient vibration monitoring, an innovative method for modal identification, called Hybrid Time and Frequency Domain Analysis, is described and a full scale test is presented. The method consists of frequency domain analysis for natural frequencies and modal shapes identification; and time domain analysis for the damping estimation. The methodology was tested in a 5 story steel frame structure constructed at the Disaster Prevent Research Institute, Kyoto University, Japan, using ambient vibration testing. The dynamic response was measured with simultaneous sensors in every floor, including ground. The modal shapes results were compared with the FEM and with previous results obtained from monitoring under forced vibration. For the damping estimation, free vibration results were compared with the ambient vibration test. The system identification obtained under ambient vibration tests are in very good agreement with the forced and free vibration tests and with the analytical results.
Combined high resolution EEG and functional MRI data for modeling of cortical sources of human movement-related potentials (2002)

High resolution electroencephalography (HREEG) and functional magnetic resonance imaging (fMRI) technologies may complement each other for the study of human brain functions in that HREEG presents excellent temporal (milliseconds) and gross spatial (centimeters) resolution, and fMRI has poor time (seconds) and high spatial (millimeters) resolution. In this study, cortical sources of human movement-related potentials were modeled using fMRI data as a constraint for linear inverse source estimation from highly sampled (128 channels) EEG data. Linear inverse source estimation from the only EEG data was used as a reference. fMRI constraint increased remarkably spatial detail of the modeled cortical sources. This indicates that integration of HREEG and fMRI data may be very useful to satisfactorily localize cortical sources of movement-related potentials.
First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery (2017)

This first-in-human trial demonstrates that intravitreal injection of ISTH0036 at the end of TE is safe. Regarding IOP control, single-dose ISTH0036 administration of 67.5 μg or 225 μg at the time of TE resulted in IOP values persistently < 10 mmHg over the three month postoperative observation period.
Immunofluorescent studies on alpha 2-plasmin inhibitor (alpha 2-PI) in glomeruli from patients with IgA nephropathy. (1985)

Detection of alpha 2-plasmin inhibitor (alpha 2-PI) and/or fibrinogen in glomeruli by immunofluorescence in 26 patients with IgA nephropathy was described. The present study showed that glomerular injuries such as glomerular adhesion to Bowman's capsule and the cellular and/or fibrous crescent were predominantly observed in glomeruli with alpha 2-PI and/or fibrinogen deposits in patients with IgA nephropathy. Alpha 2-PI coexisted with fibrinogen in glomeruli from patients with IgA nephropathy. It was postulated that the deposition of alpha 2-PI in vivo might lead to the accumulation of glomerular fibrinogen deposits in patients with IgA nephropathy. It was suggested that the depositions of alpha 2-PI and/or fibrinogen in glomeruli may be one of the exacerbative factors in glomeruli from patients with IgA nephropathy.
Detection of rubella, mumps, and measles virus genomic RNA in cells from synovial fluid and peripheral blood in early rheumatoid arthritis. (1997)

Our findings suggest rubella, mumps, or measles do not play a role in the etiopathogenesis of RA.
Supplementary Material for: An Analysis of Histone Modifications in Relation to Sex-Specific Chromatin Organization in the Mealybug <i>Maconellicoccus hirsutus</i> (2010)

The male-specific heterochromatization of the paternal genome, observed in coccids, is an example of both genomic imprinting and differential regulation of homologous chromosomes. We observed a highly nuclease-resistant chromatin (NRC) organization of a part of the paternal genome in males of <i>Maconellicoccus hirsutus</i> as reported earlier in <i>Planococcus lilacinus</i>. The nuclease resistance of NRC is correlated with nuclear matrix association and is lost when NRC is dissociated from the matrix. We carried out a comparative analysis of epigenetic modifications of histones in matrix associated chromatin of male and female mealybugs by ELISA. We detected H3K27me3, H4K20me3, H3K9me2 and H3K4me3 in both males and females and observed significant enrichment of H3K27me3 in the nuclear matrix of males compared to that of females. To further examine the presence of NRC in the germ line, nuclei were sorted based on chromatin compaction. The analysis of sorted nuclei indicates the presence of NRC in nuclei with different DNA content including the haploid nuclei from males. We discuss these results in the light of the presence of NRC exclusively in male nuclei and the retention of the maternal genome in sperm nuclei of mealybugs.
Tuberculosis Chemotherapy: The Need for New Antituberculosis Drugs is Urgent (1995)

"Tuberculosis Chemotherapy: The Need for New Antituberculosis Drugs is Urgent." American Journal of Respiratory and Critical Care Medicine, 151(4), pp. 942–943
Robust Differences in p16‐Dependent Oropharyngeal Squamous Cell Carcinoma Distant Metastasis (2015)

Our large, multi-institutional study supports published reports that p16+ OPSCC metastasizes with a unique phenotype that is hematogenous and widely disseminated with atypical end-organ sites. Our data suggest that p16+ OPSCC has a predilection toward active vasculature invasion as evidenced by the results and illustrative radiologic and pathohistologic examples. These findings may have implications for future targeted therapy when treating p16+ OPSCC.
Ceramic Nano Composites for Thermal Insulators (2014)

In this research, nanopore composite had an effect on enhancing thermal property and mechanical property. The nanopore composite maintained the pore structure and enhanced mechanical property. Al 2 O 3 xerogel was collapsed after heat treatment over 1000°C and they had weak mechanical strength because of pores. For maintenance of pore at high temperature and improvement of mechanical strength, Al 2 O 3 whisker was hybridized. The Al 2 O 3 whiskers in nanopore composite play the role of pillar during heat treatment. The mechanical property of Al 2 O 3 xerogel was improved through complexation with Al 2 O 3 whisker. The elastic modulus of nanopore composite increased 225 % from Al 2 O 3 xerogel.
Preparation and Quality Characteristics of Yogurt Added with Cultured Ginseng (2003)

Yogurt base was prepared from whole and skin milk added with of cultured ginseng ethanol extract and fermented with lactic acid bacteria (Streptococcos thermophilus : Lactobacillus bulgaricus=1:1) at for . Quality characteristics of the yogurt were evaluated in terms of acid production, number of viable cells, viscosity, and sensory property during lactic acid fermentation. Total contents of amino acids and some organic acids were analyzed. Addition of cultured ginseng extract stimulated the growth of lactic acid bacteria, and enhanced acid production and viscosity of yogurt. Total contents of amino acids of 0.5% cultured ginseng-added yogurt were higher than control group before fermentation, whereas glutamic acid, cysteine, valine, and phenyalaine contents increased after 30 h incubation. Contents of lactic, citric, and formic acids of 0.5% cultured ginseng-added yogurt increased during fermentation for 24 h. whereas decreased thereafter. Sensory scores of yogurts added with 0.5 and 1 % cultured ginseng extract were significantly higher than other groups in taste and overall acceptability. When cultured ginseng yogurt was kept at for 15 days, its quality-keeping property was relatively good.
Katalyse von Radikalreaktionen: Konzepte aus Sicht der Radikalchemie (2015)

Abstract Das Gebiet der Katalyse von Radikalreaktionen erfuhr in jüngster Zeit höchste Aufmerksamkeit. Viele interessante Radikalreaktionen wurden entdeckt und dann über Katalysezyklen erklärt. Diese Zyklen stellen allerdings selten den einzigen Weg vom Substrat zum Produkt dar. Die meisten Radikalreaktionen weisen intrinsische Ketten auf, die das Potential haben, das Produkt auch ohne Katalysator zu bilden. Wie wissen wir nun, ob eine in “katalytischen Mengen” zugegebene Verbindung einen Katalysator, einen Initiator oder gar etwas anderes darstellt? Im vorliegenden Aufsatz besprechen wir kritisch sowohl Katalysator‐freie als auch katalytische Radikalreaktionen aus Sicht der Radikalchemie. Grundlagen der Kinetik und Thermodynamik von Radikalreaktionen werden genutzt, um die Probleme der Initiierung, Propagation und Inhibierung von Radikalreaktionen zu adressieren. Katalyse von Radikalreaktionen unterscheidet sich von anderen Gebieten der Katalyse in mehreren Aspekten. Wohingegen intrinsische Kettenreaktionen schwierig zu katalysieren sind, da die zugrundeliegenden individuellen Schritte so schnell ablaufen, bieten ineffiziente Kettenprozesse und nicht‐Kettenprozesse verschiedene Möglichkeiten der Katalyse. Wir illustrieren Konzepte der Katalyse von Radikalreaktionen mit ausgewählten Beispielen aus der klassischen, aber auch der jüngsten Literatur.
Overlay Network Technologies for QoS Control (2006)

Overlay networks are expected to be a promising technology for the realization of QoS (Quality of Service) control. Overlay networks have recently attracted considerable attention due to the following advantages: a new service can be developed in a short duration and it can be started with a low cost. The definition and necessity of the overlay network is described, and the classification of various current and future overlay networks, particularly according to the QoS feature, is attempted. In order to realize QoS control, it is considered that routing overlay and session overlay are promising solutions. In particular, session and overlay networks are explained in detail since new TCP protocols for QoS instead of current TCP protocols that control congestion in the Internet can be used within overlay networks. However, many open issues such as scalability still need further research and development although overlay networks have many attractive features and possess the potential to become a platform for the deployment of new services.