gebhart/patrepeval huggingface dataset:
Automation of Perimetry: the Scoperimeter (1976)

Research Articles| March 30 2010 Automation of Perimetry: the Scoperimeter Subject Area: Ophthalmology Dirk V. Norren Dirk V. Norren Institute for Perception TNO, Soesterberg Search for other works by this author on: This Site PubMed Google Scholar Ophthalmologica (1976) 173 (3-4): 227–229. https://doi.org/10.1159/000307899 Article history Published Online: March 30 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Dirk V. Norren; Automation of Perimetry: the Scoperimeter. Ophthalmologica 31 December 1976; 173 (3-4): 227–229. https://doi.org/10.1159/000307899 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsOphthalmologica Search Advanced Search This content is only available via PDF. 1976Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed Reaction (1998)

Protein-tyrosine phosphatases (PTPases) catalysis involves a cysteinyl phosphate intermediate, in which the phosphoryl group cannot be transferred to nucleophiles other than water. The dual specificity phosphatases and the low molecular weight phosphatases utilize the same chemical mechanism for catalysis and contain the same (H/V)C(X)5R(S/T) signature motif present in PTPases. Interestingly, the latter two groups of phosphatases do catalyze phosphoryl transfers to alcohols in addition to water. Unique to the PTPase family are two invariant Gln residues which are located at the active site. Mutations at Gln-446 (and to a much smaller extent Gln-450) to Ala, Asn, or Met (but not Glu) residues disrupt a bifurcated hydrogen bond between the side chain of Gln-446 and the nucleophilic water and confer phosphotransferase activity to the Yersinia PTPase. Thus, the conserved Gln-446 residue is responsible for maintaining PTPases' strict hydrolytic activity and for preventing the PTPases from acting as kinases to phosphorylate undesirable substrates. This explains why phosphoryl transfer from the phosphoenzyme intermediate in PTPases can only occur to water and not to other nucleophilic acceptors. Detailed kinetic analyses also suggest roles for Gln-446 and Gln-450 in PTPase catalysis. Although Gln-446 is not essential for the phosphoenzyme formation step, it plays an important role during the hydrolysis of the intermediate by sequestering and positioning the nucleophilic water in the active site for an in-line attack on the phosphorus atom of the cysteinyl phosphate intermediate. Gln-450 interacts through a bound water molecule with the phosphoryl moiety and may play a role for the precise alignment of active site residues, which are important for substrate binding and transition state stabilization for both of the chemical steps.
Spinal cord compression: an unusual presentation of malignant pleural mesothelioma. A case report and review of the literature. (2012)

Pleural malignant mesothelioma is a locally invasive tumor that tends to progress due to direct extension of the tumor into the pulmonary parenchyma, the chest wall, the mediastinum, or the abdominal cavity via the diaphragm. In the later stages of the disease, distant metastases can occur. Metastases to the nervous system are rare, and clinical signs of nervous system involvement typically appear between 2 months and 6 years after the primary diagnosis. However, the case presented here manifested as neurological impairment without any respiratory symptoms.
Reachability Analysis for AWS-Based Networks (2019)

Cloud services provide the ability to provision virtual networked infrastructure on demand over the Internet. The rapid growth of these virtually provisioned cloud networks has increased the demand for automated reasoning tools capable of identifying misconfigurations or security vulnerabilities. This type of automation gives customers the assurance they need to deploy sensitive workloads. It can also reduce the cost and time-to-market for regulated customers looking to establish compliance certification for cloud-based applications. In this industrial case-study, we describe a new network reachability reasoning tool, called Tiros, that uses off-the-shelf automated theorem proving tools to fill this need. Tiros is the foundation of a recently introduced network security analysis feature in the Amazon Inspector service now available to millions of customers building applications in the cloud. Tiros is also used within Amazon Web Services (AWS) to automate the checking of compliance certification and adherence to security invariants for many AWS services that build on existing AWS networking features.
Power factor correction using projected cross point control (PCPC) (2010)

Projected cross point control (PCPC) is a new current-mode control approach which has been recently introduced. The PCPC method benefits from the advantages of traditional fixed-frequency and variable-frequency current-mode control methods. For instance, while PCPC is a fixed-frequency approach, it is stable for the entire range of the duty cycle similar to the variable-frequency hysteresis current-mode control (HCMC) scheme. In this paper, PCPC is used as the control strategy in a power factor correction (PFC) application. The results are compared with PFC methods based on the peak current-mode control (PCMC) and average current-mode control (ACMC) techniques.
Hybrid Si-SiC fast switching cell modeling and characterization including parasitic environment description by PEEC method (2002)

International audience
Leicester cough questionnaire and sputum colour chart assessment in non-cystic fibrosis bronchiectasis: A cohort analysis (2011)

Introduction: Murray et al. showed that Leicester Cough Questionnaire (LCQ) correlates with disease severity. Sputum colour chart (SCC) assessment was associated with bacterial colonization, bronchiectasis severity and FEV1. We investigated these clinical tools in a cohort of non-cystic fibrosis bronchiectasis (NCFB). Methods: 63 patients (27male, 59±18 y) with NCFB were recruited. Underlying etiologies of NCFB were analyzed and each patient was evaluated by means of spirometry and LCQ. Exacerbation rate and retrospective sputum culture results were analysed. Sputum was induced with hypertonic saline inhalation, total/differential cell count and SCC of sputum were assessed and IL-8, MCP1, bile acids, NSE and TNF-α were measured. Results: Patient sputum purulence prediction correlated significantly with SCC evaluated by the doctor (p<0.0001, r=0.72). LCQ and subscores correlated significantly with SCC (p=0.0004, r= -0.37) with more cough impact in more purulent sputa. LCQ total and subscores all correlated significantly with total number of bacteria found in retrospective sputa with worse symptoms in patients with more bacteria found (p=0.01, r= -0.32). The SCC also correlated with number of cells in sputum cell count (p<0.0001, r=0.66), IL-8 (p<0.0001, r=0.61) and TNF-alfa (p=0.0002, r=0.43). Finally, we saw worse FEV1 in patients with more purulent sputa (%: p=0.01, r= -0.37). Conclusion: Patient SCC prediction correlated with doctor SCC evaluation. LCQ, subscores and SCC correlate with lung function, presence of bacteria in all sputa and severity of airway inflammation. We conclude that LCQ and SCC are concise, simple tools and should be used in follow-up of NCFB.
Interfacing Binary Networks to Multi-valued Signals (2003)

Data processing of real-world problems usually leads to the use of quasi-continuous discrete quantities. If artificial neural networks are to be used they need to interface multivalued signals. For the case of a mixed-mode analog hardware neural network of neurons with binary inputs and outputs, this paper demonstrates that it is possible to combine these to form integer input and output neurons. A precision of 6 bits has been reached. Together with programmable synapses connecting -bit neurons to -bit neurons they represent parameterizable building blocks useful for networks of variable precision.
Interlaboratory Testing of Seven Alloys for SSC Resistance by the Double Cantilever Beam Method (1992)

Seven alloys for deep sour gas wells were evaluated for sulfide stress cracking resistance by the double cantilever beam (DCB) method. Representatives of 20 laboratories participated in one or both of two round-robin testing programs. These were conducted in support of the successful effort to include the DCB test in an expanded NACE test method, TM0177-90 (D). Test materials included cast and wrought products, low-alloy and stainless steels, and nonferrous alloys. The test results reveal generally minor variation of KISSC within data sets from individual laboratories but rather high variation between laboratories. This latter variation is greatest for the two cast alloys and lowest for wrought stainless, Ni- and Ti- base alloys. The variation between laboratories for C-90 is attributed mainly to differences in initial arm displacement; on average, KISSC rises approximately 0.2 ksi √in. per 0.001-in. increase in arm displacement. At fixed arm displacement, the DCB test for C-90 exhibits good reproducibility with a precision of ±1.34 ksi √in. (4%) or better.
Two-phase approaches to optimal model-based design of experiments: how many experiments and which ones? (2020)

Model-based experimental design is attracting increasing attention in chemical process engineering. Typically, an iterative procedure is pursued: an approximate model is devised, prescribed experiments are then performed and the resulting data is exploited to refine the model. To help to reduce the cost of trial-and-error approaches, strategies for model-based design of experiments suggest experimental points where the expected gain in information for the model is the largest. It requires the resolution of a large nonlinear, generally nonconvex, optimization problem, whose solution may greatly depend on the starting point. We present two discretization strategies that can assist the experimenter in setting the number of relevant experiments and performing an optimal selection, and we compare them against two pattern-based strategies that are independent of the problem. The validity of the approaches is demonstrated on an academic example and two test problems from chemical engineering including a vapor liquid equilibrium and reaction kinetics.
3,5-Dimethoxy-4′-methylbiphenyl (2013)

The title compound, C15H16O2, crystallizes with three independent mol-ecules in the asymmetric unit. The intra-molecular torsion angle between the aromatic rings of each mol-ecule are -36.4 (3), 41.3 (3) and -37.8 (3)°. In the crystal, the complicated packing of the mol-ecules forms wave-like layers along the b and c axes. The mol-ecules are connected via extensive meth-oxy-phenyl C-H⋯π inter-actions. A weak C-H⋯O hydrogen-bonding network also exists between meth-oxy O atoms and aromatic or meth-oxy H atoms.
Nonuniform Temporal Alignment of Slice Sequences for Four-Dimensional Imaging of Cyclically Deforming Embryonic Structures (2006)

The temporal alignment of nongated slice-sequences acquired at different axial positions in the living embryonic zebrafish heart permits the reconstruction of dynamic, three-dimensional data. This approach overcomes the current acquisition-speed limitation of confocal microscopes for real-time three-dimensional imaging of fast processes. Current synchronization methods align and uniformly scale the data in time, but do not compensate for slight variations in the heart rhythm that occur within a heartbeat. Therefore, they impose constraints on the admissible data quality. Here, we derive a nonuniform registration procedure based on the minimization of the absolute value of the intensity difference between adjacent slice-sequence pairs. The method compensates for temporal intra-sample variations and allows the processing of a wider range of data to build functional, dynamic models of the beating embryonic heart. We show reconstructions from data acquired in living, fluorescent zebrafish embryos
VLSI implementation of neural networks (1990)

High mutation rates resulting from the error prone replicases of RNA viruses could lead to antigenic alterations in viral products and pose significant problems during the manufacture of vaccines against RNA viruses. The production of a vaccine against tick-borne encephalitis virus has been monitored using both polyclonal sera and a library of monoclonal antibodies. Only a few antigenic changes were detected during the alteration of host cell from mouse brain to avian fibroblasts and upon subsequent expansion of the virus population during several rounds of replication. In addition, when the formalin inactivation process was monitored for antigenic change, virtually none was detected.
Microbial Desalination Cells with Efficient Platinum‐Group‐Metal‐Free Cathode Catalysts (2017)

Abstract An iron‐nitrogen‐carbon‐based catalyst was used at the cathode of a microbial desalination cell (MDC) and compared with platinum (Pt) and an activated carbon (AC) cathode. The Fe‐N−C catalyst was prepared by using nicarbazin (NCB) as the organic precursor through a sacrificial support method (SSM). Rotating ring disk electrode (RRDE) experiments show that Fe‐NCB had a higher electrocatalytic activity compared to AC and Pt. The utilization of Fe‐NCB in the cathode substantially improved the performance output with an initial maximum power density of 49±2 μW cm −2 in contrast to Pt and AC catalysts, which show lower values of 34±1 and 23.5±1.5 μW cm −2 , respectively. After four cycles, Fe‐NCB catalyst lost 15 % of its initial performance, but still was 1.3 and 1.8 times more active than Pt and AC, respectively. Solution conductivity inside the desalination chamber (DC) decreased by 46–55 % with every cycle. The pH of the cathodic chamber and the DC increased to 10–11, owing to the production of OH − during the oxygen reduction reaction and the migration of OH − into the DC. Chemical organic demand decreased by 73–83 % during each cycle. It was shown that Fe‐NCB and Pt had a similar coulombic efficiency (CE) of 39±7 % and 38±2 %, whereas AC had lower CE (24±5 %).
Context-Aware Notification Management in an Integrated Collaborative Environment (2009)

Abstract. The e-collaboration tools available in open environments offer services supporting the interaction and the synchronization between users, who are typically involved in parallel activity spheres; e.g., different projects and home schedules. However, such tools provide the user’s with separate views on her activities and collaborations; moreover, they support workspace awareness by delivering unstructured notification streams, which challenge the user’s attention and cannot be filtered or grouped on a relevance basis. As an answer to this issue, we present an Integrated Collaborative Environment offering a unified view of the user’s parallel collaboration spheres. This environment includes a notification management model supporting the selective deferral of notifications on the basis of the user’s focus of attention. 1
The vitamin C route to the ciguatoxins: enantioselective synthesis of a ring F building block (2000)

A ten-step enantioselective synthesis of an F ring lactone for CTX antibody assay development, employing vitamin C as a starting material, is described.
Errors and reproducibility in electron-density map interpretation (1999)

Three investigators, with varying levels of experience, independently built and refined the structure of Escherichia coli ribokinase at 2.6 A resolution. At the end of the refinement/rebuilding processes the models had essentially converged, although each had its own particular pattern of remaining errors. The subsequent refinement of the same structure at 1.8 A resolution allowed an overall quality check of each of the lower resolution models, and an analysis of which graphics-based tools were generally most efficient in locating these errors. Criteria which are useful in the application of Ramachandran, main-chain and side-chain database and real-space fit analyses are presented.
GROWTH HORMONE-RELEASING FACTOR BINDING SITES IN RAT ANTERIOR PITUITARY MEMBRANE HOMOGENATES: MODULATION BY GLUCOCORTICOIDS (1985)

Specific high affinity binding sites for growth hormone releasing factor (GRF) were described in rat anterior pituitary homogenates with use of the analog [His1-mono-125I-Tyr10,Nle27]-hGRF(1-32)-NH2 as radioligand. Computerized analysis of competition experiments indicated one class of specific high affinity binding sites with a dissociation constant of 0.19 nM. The relative binding affinities of rGRF, hGRF(1-40) and various analogs correlated well with their in vitro biological potencies. Further, the number binding sites was drastically decreased after adrenalectomy; chronic dexamethasone treatment of these animals restored GRF binding capacity to control without changing binding affinity. These results may in part explain the enhanced responsiveness of the somatotroph after dexamethasone treatment.
Parallel and perpendicular hole transport in heterostructures with high AlAs mole-fraction barriers (1991)

The potential advantages of high-barrier quantum well structures for p-channel field-effect transistors are investigated in measurements of parallel and perpendicular hole transport in high AlAs mole fraction heterostructures. The hole mobility in GaAs and (In,Ga)As quantum wells confined by (Al,Ga)As barriers and current-voltage characteristics of metal-(Al,Ga)As/GaAs diodes are examined in structures with AlAs mole fractions as high as 0.85. Hole mobilities of nearly 5000 cm2/V s with a density of 1.0×1012 cm−2 are obtained at 77 K and reductions in perpendicular currents by several orders-of-magnitude are obtained at 300 and 77 K.
An algebraic theory of componentised interaction (2013)

This thesis provides a specification theory with strong algebraic and compositionality properties, allowing for the systematic construction of new components out of existing ones, while ensuring that given properties continue to hold at each stage of system development. The theory shares similarities with the interface automata of de Alfaro and Henzinger, but is linear-time in the style of Dill's trace theory, and is endowed with a richer collection of operators. Components are assumed to communicate with one another by synchronisation of input and output actions, with the component specifying the allowed sequences of interactions between itself and the environment. When the environment produces an interaction that the component is unwilling to receive, a communication mismatch occurs, which can correspond to run-time error or underspecification. These are modelled uniformly as inconsistencies. A linear-time refinement preorder corresponding to substitutivity preserves the absence of inconsistency under all environments, allowing for the safe replacement of components at run-time. To build complex systems, a range of compositional operators are introduced, including parallel composition, logical conjunction and disjunction, hiding, and quotient. These can be used to examine the structural behaviour of a system, combine independently developed requirements, abstract behaviour, and incrementally synthesise missing components, respectively. It is shown that parallel composition is monotonic under refinement, conjunction and disjunction correspond to the meet and join operations on the refinement preorder, and quotient is the adjoint of parallel composition. Full abstraction results are presented for the equivalence defined as mutual refinement, a consequence of the refinement being the weakest preorder capturing substitutivity. Extensions of the specification theory with progress-sensitivity (ensuring that refinement cannot introduce quiescence) and real-time constraints on when interactions may and may not occur are also presented. These theories are further complemented by assume-guarantee frameworks for supporting component-based reasoning, where contracts (characterising sets of components) separate the assumptions placed on the environment from the guarantees provided by the components. By defining the compositional operators directly on contracts, sound and complete assume-guarantee rules are formulated that preserve both safety and progress. Examples drawn from distributed systems are used to demonstrate how these rules can be used for mechanically deriving component-based designs.
Deploying Mobile Nodes to Connect Wireless Sensor Networks Using Novel Algorithms (2007)

Wireless sensor networks receive lots of attention due to its promising techniques and wide-ranging applications in recent years. The kind of network occasionally becomes disconnected due to initial uneven deployments or unpredictable failures or run out of battery of sensor nodes. However, sensor nodes with mobility then can be used in an addition deployment to reconnect the disconnected sensor networks. Theoretically, the augmenting geometric graph problem is defined here to model this kind of connectivity issues. The work proposes two novel algorithms: the graph-oriented algorithm and the divide-and-conquer algorithm to connect disconnected networks by using as less as possible mobile nodes. The first algorithm highly exploits traditional graph and geometry techniques including Fermat point, convex hull, nearest neighbor, minimum cost spanning tree, and graph contraction. Adopting a quite different approach, the second algorithm resolves the problem by dividing the deployed area and merging sub-solutions recursively. With respect to complexity issue, the graph-oriented algorithm takes 0(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) time; on the other hand, the divide-and-conquer algorithm requires 0(n log n) time, where n is the size of vertex set of the given graph G=(V, E). These proposed two algorithms have low time complexity and can be implemented in a centralized sensor network.