gebhart/patrepeval huggingface dataset:
Local Anesthetics. 3-Halo-4-dialkylaminoalkoxy-5-alkoxyanilines (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLocal Anesthetics. 3-Halo-4-dialkylaminoalkoxy-5-alkoxyanilinesD. F. PAGE and R. O. CLINTONCite this: J. Org. Chem. 1962, 27, 1, 218–226Publication Date (Print):January 1, 1962Publication History Published online1 May 2002Published inissue 1 January 1962https://pubs.acs.org/doi/10.1021/jo01048a055https://doi.org/10.1021/jo01048a055research-articleACS PublicationsRequest reuse permissionsArticle Views317Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chromosomal instability in fibroblasts and mesenchymal tumors from 2 sibs with Rothmund-Thomson syndrome (1998)

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive genodermatosis associated with increased risk of mesenchymal tumors. The putative gene has been provisionally assigned to chromosome 8. Using a cytogenetic-molecular approach, we studied lymphocytes, fibroblasts, osteosarcoma (OS) and malignant fibrous histiocytoma (MFH) from 2 affected fraternal twins, looking for constitutive markers of chromosome instability and tumor chromosomal changes which might reflect the common genetic background. The rate of spontaneous chromosome aberrations was not increased in lymphocytes. Conversely, karyotyping of primary fibroblasts from one sib evidenced chromosome breaks and both numerical and structural chromosome changes in 24% and 17% of the metaphases respectively. FISH of a 8q21.3 cosmid allowed us to detect trisomy of the target region on 7% of fibroblast nuclei from both sibs, 47% and 12% of OS and MFH cells. Pronounced chromosomal instability and clonal rearrangements leading to different chromosome-8 derivatives were detected in both tumors. CGH experiments showed multiple gains/losses, among which del(6q), also revealed by cytogenetics, and 7p gain were common, whereas 8q amplification was present only in OS. Chromosomal instability, observed in fibroblasts from the RTS patients studied, accounts for the increased risk of mesenchymal tumors in these patients.
A simple, inexpensive technique for clearing obstructed closed suction drainage catheters. (1985)

Closed suction drains are frequently used after a variety of surgical procedures. Occlusion of these drains by thrombus or debris is a common postoperative event. A simple, inexpensive technique for clearing occluded drains with the readily available polyvinylpropylene catheter used for central venous cannulation is described herein. This method represents an inexpensive alternative to a Fogarty balloon tipped thrombectomy catheter for the same purpose. Prompt recognition and clearance of an obstructed drain is essential to minimize postoperative wound complications.
Effect of adrenocortical steroids and adrenocorticotrophic hormone on electroshock seizure threshold. (1952)

The effect of six adrenocortical steroids on the electroshock seizure threshold (EST) of rats has been tested. DCA and Compound S acetate (11-desoxy-17-hydroxycorticosterone acetate) in a dose of 2 mgm. per day elevated EST DCA was much more potent than Compound S. Compound B acetate (corticosterone acetate), in a dose of 2 mgm. per day, did not significantly alter EST. In doses of 2 mgm. per day, Compound A acetate (11-dehydrocorticosterone acetate) induced a slight decrease, Compound F acetate (17-hydroxycorticosterone acetate) a considerable decrease and cortisone acetate (11-dehydro-17-hydroxycorticosterone acetate) a marked decrease in EST. ACTH, at dose levels of 0.5, 0.001 and 0.0001 U.S.P. Unit, given in combination with DCA, completely inhibited the elevation of EST observed after DCA alone. DCA, given in combination with cortisone acetate, inhibited the decrease in EST observed after cortisone acetate alone. In one experiment, but not in another, ACTH (0.5 U.S.P. Unit per day), given in combination with cortisone, antagonized to a slight extent the decrease in EST observed after cortisone alone. The reason for the discrepancy is discussed. ACTH (0.5 U.S.P. Unit per day) alone resulted in an increase of 11 per cent in EST after 28 days. Compound A acetate, given in combination with cortisone acetate, partially prevented the decrease in EST observed after cortisone acetate alone. Compound S acetate, given in combination with cortisone acetate, did not prevent the decrease in EST observed after cortisone. The clinical significance of the effects of adrenocortical steroids on brain ex citability is briefly discussed.
Evidence for Mitochondrial Regulation of Photosynthesis by a Starchless Mutant of Nicotiana sylvestris (1992)

Mutant NS458 of Nicotiana sylvestris (Speg. et Comes) contains a defective plastid phosphoglucomutase and accumulates only trace amounts of starch. Determinations of carbon partitioning using tracer d-[3-(14)C]glyceric acid showed that the maximal CO(2) assimilation by mature leaves of the mutant at saturating [CO(2)] and light and low [O(2)] was close to the flux for sucrose formation in the wild type. The mutant is characterized by exceptionally slow oscillations in maximal CO(2) assimilation. The postulate that these slow oscillations follow changes in the cytosolic rate of sucrose phosphate synthesis has been investigated. Studies with wild-type and mutant leaf discs subjected to various treatments failed to indicate that any significant activation-inactivation cycle in sucrose-P synthase activity can occur. The rate of sucrose phosphate synthesis, however, might be altered by variations in the supply of uridine UDP-glucose which is controlled by the rate of ATP regeneration (via UTP regeneration). Treating mutant leaf protoplasts and young leaves with oligomycin, an inhibitor of mitochondrial ATP regeneration, reduced photosynthesis by as much as 25 and 40%, respectively. The wild type failed to show inhibition by oligomycin, i.e. its effect is masked when starch and sucrose synthesis can interact. It is concluded that maximal CO(2) assimilation in the mutant is fine tuned by mitochondrial metabolism such that interactions between sucrose synthesis and mitochondrial processes may generate the observed oscillations.
Formation of meprobamate from carisoprodol is catalysed byCYP2C19 (1996)

Carisoprodol is a muscle relaxant analgesic, which has an active metabolite i.e. meprobamate. We conducted an open three-panel single-dose administration study with 15 healthy volunteers: five poor metabolizers of mephenytoin, five poor metabolizers of debrisoquine and five extensive metabolizers of both substrates. The aim was to investigate if the elimination of carisoprodol and meprobamate is dependent on the two metabolic polymorphisms of mephenytoin and debrisoquine. The subjects were given single oral doses of 700 mg carisoprodol and 400 mg meprobamate on separate occasions. The disposition of carisoprodol was clearly correlated to the mephenytoin hydroxylation phenotype. The mean serum clearance of carisoprodol was four times lower in poor metabolizers of mephenytoin than in extensive metabolizers, which confirms the hypothesis from our previous study that N-dealkylation of carisoprodol cosegregates with the mephenytoin hydroxylation polymorphism. However, mean serum clearance of meprobamate did not differ between the two groups. Also, polymorphic debrisoquine hydroxylation did not influence the elimination of carisoprodol or meprobamate. Poor metabolizers of mephenytoin thus have a lower capacity to metabolize carisoprodol and may therefore have an increased risk of developing concentration dependent side-effects such as drowsiness and hypotension, if treated with ordinary doses of carisoprodol.
Meta data to support context aware mobile applications (2004)

The greater sophistication and availability of mobile computing devices is enabling the application of computing to new tasks and applications to be experienced in a wide range of contexts. To facilitate such applications it is necessary to adapt the applications and the data they display to operate within the limitations of the context of use, take advantage of the strengths of the devices and best support the users in their tasks. A part of the solution to this issue is the description of the data available to the applications. Meta data may describe the structure and properties of information and data. We achieve this by separating the semantic elements of the information from the syntactic variants which realise them in order to form documents. In this paper we describe a new meta data model which can encode this description. We provide example meta data and illustrate how this may lead to better application usability than current simplistic or constrained approaches, through contextual mediation.
Fingerprint Spoof Detection Using Quality Features (2015)

Biometrics refers to automated recognition of individuals based on their biological and behavioral characteristics. Biometric systems are widely used for security. They are used in forensic and commercial applications. Among all biometric techniques, fingerprint recognition is the most widely used for personal identification systems due to its permanence and uniqueness. But biometric systems are vulnerable to certain type of attacks. Spoofing refers to the fraudulent action by an unauthorized person into biometric systems using fake input that reproduces one of the authorized person's biometric input.
Hepatitis C: a public health response in Kansas. (2004)

The hepatitis C (HCV) infection prevalence in Kansas is concentrated in populations with increased risk factors for acquiring the virus. Testing the appropriate population and providing counseling and medical referral to these high risk individuals is accomplished by offering HCV testing at HIV Counseling and Testing sites across the state. Such public health programs along with the medical community allow the at risk populations of Kansas an opportunity to improve their health and decrease the spread of HCV
Pharmacologic management of Paget's disease. (1989)

The pathogenesis, clinical features, indications for therapy, and current pharamacologic management of Paget's disease are reviewed. Paget's disease is a bone disorder of unknown etiology primarily affecting the elderly. Overactive bone resorption leads to the accelerated formation of disorganized, weak bone. Pain and fractures are common clinical features. Neurologic, cardiovascular, metabolic, and neoplastic complications are also reported. Because most patients are asymptomatic, the disease is often detected during routine roentgenography or laboratory tests. Primary indications for pharmacologic intervention include bone pain, neural compression, immobilization hypercalcemia or hypercalciuria, cardiac failure, and orthopedic surgery. Recurrent or non-healing fractures and rapidly progressing complications are additional indications. Drugs used in the management of Paget's disease include calcitonin, etidronate disodium, and plicamycin. Although these agents are efficacious, each has disadvantages. Clinical resistance to animal calcitonins may develop, and the cost of therapy may be prohibitive. Etidronate may induce ostemalacia. The use of plicamycin is limited by potentially severe toxicities. Dichloromethylene and aminohydroxypropylidene are promising diphosphonate compounds but are still investigational In those patients who are unresponsive to single-agent regimens, combination therapy may prove effective. Although many patients with Paget's disease do not require pharmacologic therapy, calcitonin and etidronate are the agents of choice when it is indicated.
Inert Gas Narcosis — An Introduction (1966)

Journal Article Inert Gas Narcosis — An Introduction Get access I P Unsworth, B.M., B.Ch., L.R.C.P. I P Unsworth, B.M., B.Ch., L.R.C.P. Walton Hospital, Liverpool Search for other works by this author on: Oxford Academic Google Scholar Postgraduate Medical Journal, Volume 42, Issue 488, June 1966, Pages 378–385, https://doi.org/10.1136/pgmj.42.488.378 Published: 01 June 1966
Reduction of fatty acid flux results in enhancement of astaxanthin synthesis in a mutant strain of Phaffia rhodozyma (2010)

A moderate-temperature mutant strain of the yeast Phaffia rhodozyma, termed MK19, was selected by 1-methyl-3-nitro-1-nitrosoguanidine (NTG) and Co60 mutagenesis. MK19 displayed fast cell growth and elevated astaxanthin content at 25 degrees C, whereas optimal temperature for growth and astaxanthin synthesis of wild-type P. rhodozyma was 17-21 degrees C. Optimized astaxanthin yield for MK19 after 4 days culture in shaking flask at 25 degrees C, determined by response surface methodology, was 25.8 mg/l, which was 17-fold higher than that of the wild-type. MK19 was tolerant of high initial concentration of glucose (>100 g/l) in optimized medium. Total fatty acid content of MK19 was much lower than that of the wild-type. Acetyl-CoA is a common precursor of fatty acid and terpenoid biosynthesis, and it is possible that decreased fatty acid synthesis results in transfer of acetyl-CoA to the carotenoid biosynthetic pathway. Our results indicate that astaxanthin content is negatively correlated with fatty acid content in P. rhodozyma. Nutrient analysis showed that MK19 cells are enriched in lysine, vitamin E, and other rare nutrients, and have potential application as fish food without nutritional supplementation. This moderate-temperature mutant strain is a promising candidate for economical industrial-scale production.
Stopping Cross Sections of Some Hydrocarbon Gases for 40-250 keV Protons and Helium Ions (1963)

The stopping cross sections of air, He, C${\mathrm{H}}_{4}$, ${\mathrm{C}}_{2}$${\mathrm{H}}_{2}$, ${\mathrm{C}}_{2}$${\mathrm{H}}_{4}$, ${\mathrm{C}}_{3}$${\mathrm{H}}_{8}$, ${(\mathrm{C}{\mathrm{H}}_{2})}_{3}$, and ${\mathrm{C}}_{3}$${\mathrm{H}}_{6}$ have been measured for protons in the energy range 40 to 250 keV. The stopping cross sections of ${\mathrm{C}}_{2}$${\mathrm{H}}_{4}$ and ${\mathrm{C}}_{3}$${\mathrm{H}}_{8}$ were also measured for helium ions. The data are in good agreement with previous experimental work, and have standard deviations between 1.5 and 4%. They clearly demonstrate the failure of the Bragg rule of additivity for proton energies less than 150 keV. The helium-ion data indicate that the effect of chemical binding on stopping cross sections is unlikely to be any greater for incident helium ions than for incident protons at the same energy.
Automatic height estimation from speech in real-world setup (2010)

We propose a Gaussian process based regression scheme that provides a direct estimation of the height of unknown speakers and is applicable to real-world autonomous surveillance applications. This scheme relies on utterance-level speech parameterization followed by regression modelling, which estimates the height of the speaker and the uncertainty interval of that estimation. Experiments on the TIMIT database demonstrated that a feature vector composed of the top-50 ranked parameters offers a good trade-off between computational demands and accuracy. The proposed scheme for automatic height estimation was evaluated in the smart-home and public security scenarios offered by the PROMETHEUS database. The averaged relative error of height estimation remained approximately 3%, in both indoor and outdoor conditions, which indicates the good robustness of the proposed scheme.
Advanced flame‐retardant epoxy resins from phosphorus‐containing diol (2005)

Abstract Phosphorus‐containing epoxy systems were prepared from isobutylbis(hydroxypropyl)phosphine oxide (IHPO) and diglycidyl ether of bisphenol A (DGEBA). Diethyl‐ N,N ‐bis(2‐hydroxyethyl) aminomethyl phosphonate (Fyrol 6) could not be incorporated into the epoxy backbone by a reaction with either epichlorohydrin or DGEBA because intramolecular cyclization took place. The curing behavior of the IHPO–DGEBA prepolymer with two primary amines was studied, and materials with moderate glass‐transition temperatures were obtained. V‐0 materials were obtained when the resins were tested for ignition resistance with the UL‐94 test. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 3510–3515, 2005
Dextrorphan and dextromethorphan: comparative antitussive effects on guinea pigs. (1994)

Dextromethorphan, after administration, is rapidly and extensively transformed into dextrorphan. The aim of this study was to compare the cough-suppressing activity of 6, 12, 24, 48 mg/kg, i.p., of dextrorphan (dextro rotatory isomer of racemorphan) with that of dextromethorphan, using the model of citric acid-induced coughing in the unanaesthetized, unrestrained guinea pig. A significant dose-effect relationship of dextrorphan in reducing citric acid-induced cough was observed. This effect was comparable with that of dextromethorphan. However, at 48 mg/kg, i.p., dextromethorphan had a toxic effect while dextrorphan did not. Because dextrorphan is the major metabolite of dextromethorphan and has antitussive activity comparable to that of dextromethorphan, clinical use of dextrorphan is suggested.
소요산과 (逍遙散) 청간소요산이 (淸肝逍遙散) 스트레스 생쥐의 뇌부위별 Monoamines 함량에 미치는 영향 (1998)

This study aimed to evaluate the anti-stress effects of soyosan and chyengansoyosan on the contents cold swimming stress. The experimental animals were forced cold swimming stress for 3 minutes, and administered 4㎎/10g of soyosan and chyengansoyosan extract for 7 days before stress. The monoamines contents were measured by HPLC method in various part of mouse brain. The following results were obtained : 1. In frontal cortex, the contenrs of norepinephrine ans dopamine increased significantly in the group administered chyrngansoyosan compared with in the group administered non chyengansoyosan and soyosan(control group) of mice stressed by cold swiming. 2. In hypothalamus, the content of norepinephrine increased with statistical significance in the group administered soyosan compared with control group of mice stressed by cold swimming. 3. The content of dopamine increased with statistical significance on the group administered chyenfansoyosan and compared with control group of mice stressed by cold swimming in hypothlaamus and hippocampus. 4. The content of serotonin increased with statistical significance in the group administered soyosan and compared with control group of mice stressed by cold swimming in hippocampus and corpus striatum. 5. In corpus striatum and hippocampus, the content of norepineohrine decreased with statistical significance in the group administered soyosan and chyengandoyosan compared with control group of mice stressed by cold swimming. Judgding from the above results, this sthdy reaches a conclusion that soyosan or chyengansoyosas has significant effects in reducing stress.
Fresh, Disintegrated Platelets in Radiation Thrombocytopenia: Correction of Prothrombin Consumption without Correction of Bleeding. (1959)

When irradiated dogs developed severe thrombocytopenia and purpura, the thoracic duct was cannulated and output of red cells/minute counted to quantitate bleeding tendency. Fresh canine platelets disintegrated in a sonic oscillator and infused into the dogs increased prothrombin consumption towards the normal range, but had no effect on bleeding tendency. Intact platelets, however, had an immediate and dramatic effect on bleeding tendency. We conclude that a normal clotting system, including platelet factors, is not enough for normal hemostasis; the mechanical effect of intact platelets is also needed. Consequently, non-intact platelets or platelet substitutes may not be expected to improve the bleeding tendency in thrombocytopenia.
Myoblasts from affected and non‐affected FSHD muscles exhibit morphological differentiation defects (2008)

Facioscapulohumeral dystrophy (FSHD) is a muscular hereditary disease with a prevalence of 1 in 20,000 caused by a partial deletion of a subtelomeric repeat array on chromosome 4q. However, very little is known about the pathogenesis as well as the molecular and biochemical changes linked to the progressive muscle degeneration observed in these patients. Several studies have investigated possible pathophysiological pathways in FSHD myoblasts and mature muscle cells but some of these reports were apparently in contradiction. The discrepancy between these studies may be explained by differences between the sources of myoblasts. Therefore, we decided to thoroughly analyze affected and unaffected muscles from patients with FSHD in terms of vulnerability to oxidative stress, differentiation capacity and morphological abnormalities. We have established a panel of primary myoblast cell cultures from patients affected with FSHD and matched healthy individuals. Our results show that primary myoblasts are more susceptible to an induced oxidative stress than control myoblasts. Moreover, we demonstrate that both types of FSHD primary myoblasts differentiate into multi-nucleated myotubes, which present morphological abnormalities. Whereas control myoblasts fuse to form branched myotubes with aligned nuclei, FSHD myoblasts fuse to form either thin and branched myotubes with aligned nuclei or large myotubes with random nuclei distribution. In conclusion, we postulate that these abnormalities could be responsible for muscle weakness in patients with FSHD and provide an important marker for FSHD myoblasts.
Automatic Acquisition of Hyponyms and Meronyms from Question Corpora (2002)

We explore how lexical and ontological relations can be acquired automatically from natural language questions. The focus in this paper is on identifying hyponym and meronym relations by using simple pattern matching. It is shown that natural language questions can provide a significant source for ontological information.
Fourth DecTec Africa held : awards / events (2011)

I popped into the fourth DecTec Africa labelling, product decoration and packaging conference, held on 27-28 June at the Hilton Sandton.
Surface current effects on the fetch‐limited growth of wave energy (2007)

To study the fetch‐limited growth of wind wave energy over a region with significant lateral shear of the current field, this study exploited data obtained from two linear phased‐array High Frequency (HF) radar systems. Both the near‐surface currents and wave energy and period were mapped over the highly sheared inshore boundary of the Florida Current. The wave energy growth during two periods when the winds were steady for >12 hours and were directed offshore was computed over a range of fetches from 5 to 45 km. The observed energy growth rates were significantly (∼50 %) lower than predicted by the Donelan et al. (1992) empirical formulation over the high vorticity region. The reduced growth rate was consistent with a shift of the wind stress direction into the current direction due to refraction of the wave field. Dimensionless wave energy increased by as much as 100% over neighboring values when the vertical component of the surface current vorticity was a global minimum. While trapping and enhancement of wave energy is predicted by wave ray theory, it has never before been confirmed within the Florida Current with coincident wave and current measurements.