gebhart/patrepeval huggingface dataset:
New short‐chain analogs of a substance‐P antagonist inhibit proliferation of human small‐cell lung‐cancer cells <i>in vitro and in vivo</i> (1995)

Human small-cell lung-cancer cells (SCLC) produce and secrete gastrin-releasing peptide (GRP), the mammalian equivalent of bombesin (BN). There is some evidence to suggest that GRP is an autocrine regulator of SCLC cell growth. In the search for potent BN antagonists, several substance-P (SP) analogs were found to inhibit the growth of SCLC cells. We found that a known short-chain SP antagonist, pHOPA-DTrp-Phe-DTrp-Leu-Leu-NH2(NY3238), inhibits the binding of 125I-Tyr4-BN on Swiss 3T3 cell line expressing BN receptors, as well as the proliferation of NCI-H69 SCLC cells. In this study we tested several analogs of NY3238 and we found that NY3521 and NY3460 are more effective in inhibition of proliferation of SCLC cells but less potent in inhibition of binding of 125I-Tyr4-BN on Swiss 3T3 cells than NY3238. Furthermore, we detected specific binding of radiolabelled NY3238 even below 1 nM on NCI-H69 cells that could have been inhibited by SP and NY3460 rather than by BN. In addition to these in vitro studies, NY3460 proved to be effective in inhibiting the growth of NCI-H69 SCLC xenografts in nude mice in vivo. These analogs of NY3238 could be promising therapeutic agents in the treatment of SCLC.
The Medaka Genome: Why We Need Multiple Fish Models in Vertebrate Functional Genomics (2006)

Medaka (Oryzias latipes) is widely used in research in the fields of biology, medicine, environmental science and fisheries. Zebrafish and medaka are well established as genetic model systems in which large-scale mutagenesis has been successfully performed, and for which EST data, BAC libraries, and fine linkage maps have been accumulated. Among rayfinned fish, there is a large evolutionary distance between medaka and zebrafish. In contrast, the evolutionary distance between medaka and two species of pufferfish, fugu (Takifugu rubripes), and tetraodon (Tetraodon nigroviridis), is almost comparable to that between humans and rodents, and the current genome project is showing that their genome organization is well conserved. Comparison of genome structure among teleosts and mammals helps our understanding of the orthologous gene structure and the evolution of gene families in vertebrates. In addition, gene functions have to be analyzed by both forward and reverse genetics. The Targeting Induced Local Lesions IN Genome (TILLING) system, which includes random mutagenesis, followed by screening for induced mutations in the target genes, is a powerful tool for studying the functional genomics of both medaka and zebrafish.
The Effects of Age on Postprandial Thermogenesis at Four Graded Energetic Challenges: Findings in Young and Older Women (1998)

There remains controversy over the effect of age on postprandial thermogenesis, with some studies observing decreased postprandial thermogenesis in older subjects and other studies finding no effect of age. We investigated this issue in 8 young (25.2+/-1.8 years) and 8 older (72.2+/-2.1 years) healthy glucose-tolerant women with normal thyroid hormone status. Repeated measures of the thermic effect of feeding (TEF) were obtained following consumption of test meals containing 0, 1046, 2092, and 4184 kilojoules (kJ) by using indirect calorimetry. TEF at each meal size was determined once in the older subjects and twice in the younger subjects (during follicular and luteal phases of the menstrual cycle) for a total of 96 measurements. There was a positive dose-response between meal size and TEF (p < .001) that was not significantly affected by age group. The best single predictor of TEF expressed as a percentage of meal energy content was waist-to-hip ratio (R2=67.416, p < .02). These results indicate that aging is not associated with decreased TEF in the absence of factors such as a hypothyroid state or glucose intolerance.
Pulmonary thromboembolism in an emergency hospital: Are our patients different? (2017)

In our emergency hospital, PTE is a relatively rare cause of hospitalization; the rate is, however, comparable with other major hospitals. Dyspnea and pleuritic chest pain was the clinical presentation dyad. UFH was the preferred anticoagulant for in-hospital treatment while AVK was the preferred option for long term treatment and recurrence prophylaxis; however an increasing number of patients are prescribed NOAC. In older patients clinical severity was higher upon presentation, hospitalization duration was increased and cancer was more frequently associated. Younger patients associated more frequently a primary hypercoagulable state and recurrent thromboembolism. Mortality rate was low during hospitalization, comparable with that seen in other studied populations.
<i>Nanos</i> and <i>pumilio</i> establish embryonic polarity in <i>Drosophila</i> by promoting posterior deadenylation of <i>hunchback</i> mRNA (1997)

Nanos protein promotes abdominal structures in Drosophila embryos by repressing the translation of maternal hunchback mRNA in the posterior. To study the mechanism of nanos-mediated translational repression, we first examined the mechanism by which maternal hunchback mRNA is translationally activated. In the absence of nanos activity, the poly(A) tail of hunchback mRNA is elongated concomitant with its translation, suggesting that cytoplasmic polyadenylation directs activation. However, in the presence of nanos the length of the hunchback mRNA poly(A) tail is reduced. To determine if nanos activity represses translation by altering the polyadenylation state of hunchback mRNA, we injected various in vitro transcribed RNAs into Drosophila embryos and determined changes in polyadenylation. Nanos activity reduced the polyadenylation status of injected hunchback RNAs by accelerating their deadenylation. Pumilio activity, which is necessary to repress the translation of hunchback, is also needed to alter polyadenylation. An examination of translation indicates a strong correlation between poly(A) shortening and suppression of translation. These data indicate that nanos and pumilio determine posterior morphology by promoting the deadenylation of maternal hunchback mRNA, thereby repressing its translation.
Solid-Supported Hyperbranched Polymerization:  Evidence for Self-Limited Growth (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSolid-Supported Hyperbranched Polymerization: Evidence for Self-Limited GrowthP. Bharathi and Jeffrey S. MooreView Author Information Roger Adams Laboratory, Departments of Chemistry and Materials Science & Engineering The Beckman Institute for Advanced Science and Technology University of Illinois at Urbana−Champaign Urbana, Illinois 61801 Cite this: J. Am. Chem. Soc. 1997, 119, 14, 3391–3392Publication Date (Web):April 9, 1997Publication History Received12 September 1996Published online9 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ja9632062https://doi.org/10.1021/ja9632062rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views636Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Monomers,Physical and chemical properties,Polymerization,Polymers,Size exclusion chromatography Get e-Alerts
Laurence Batchelder's contributions to the Acoustical Society of America (1991)

Laurence Batchelder was a consistent, well-diversified contributor to the Acoustical Society of America from the time he joined the Society in 1946 throughout the remainder of his life. When you ask different members of the Society what he did, you are likely to receive a unique answer, because he shared his expertise with each of them in a different and very personal way. Some of this interaction is being presented by other speakers in this session. A few chronological highlights of his ASA career are that Larry was elected a Fellow of the Society in 1949, served on the Executive Council from 1952–1954, and again as President-Elect, President, and Past President from 1960–1963, received the first Distinguished Service Citation awarded by the Society in 1972, and most recently was awarded the Gold Medal for 1985, the highest award of the Society for contributions to acoustics.
Photooxidation of 8-Oxo-7,8-dihydro-2‘-deoxyguanosine by Thermally Generated Triplet-Excited Ketones from 3-(Hydroxymethyl)-3,4,4-trimethyl-1,2-dioxetane and Comparison with Type I and Type II Photosensitizers (1996)

Calf thymus DNA and 8-oxo-7,8-dihydro-2‘-deoxyguanosine (8-oxodGuo) were photooxidized in the dark by triplet-excited ketones generated in the thermal decomposition of 3-(hydroxymethyl)-3,4,4-trimethyl-1,2-dioxetane (HTMD). The oxidation of DNA led to 8-oxodGuo and the type I photooxidation product 2,2-diamino[2-deoxy-β-d-erythro-pentofuranosyl)-4-amino]-5(2H)-oxazolone (oxazolone). While the yield of oxazolone progressively increased, 8-oxodGuo was substantially consumed in DNA on successive exposure to HTMD. The oxidation of authentic 8-oxodGuo by HTMD and established photosensitizers such as benzophenone (mainly type I) and Rose Bengal (predominantly type II) was studied in detail in regard to the concentration and time dependence and the influence of D2O versus H2O. The singlet-oxygen-derived 4R* and 4S* diastereomers of 4-hydroxy-8-oxo-4,8-dihydro-2‘-deoxyguanosine (4-HO-8-oxodGuo) and oxazolone were the major products. A substantial kinetic D2O effect (ca. 10-fold) in the Rose Bengal-photosensitized degradation of 8-oxodGuo unequivocally established that in this case singlet oxygen (type II photooxidation) is involved. However, the efficient formation of oxazolone by benzophenone as a characteristic type I photooxidant, as well as in the HTMD-mediated oxidation (predominantly type I), and the fact that these processes exhibit a negligible D2O effect provide cogent experimental evidence for an electron or hydrogen atom transfer mechanism (type I photooxidation) in the oxidative degradation of 8-oxodGuo into oxazolone. The unprecedented observation that comparable product ratios of 4-HO-8-oxodGuo and oxazolone were obtained in the 8-oxodGuo oxidations, irrespective of whether Rose Bengal as a typical type II photooxidant or benzophenone as an established type I photooxidant was employed, is presumably due to electron-transfer chemistry of 1O2 with the easily oxidized 8-oxodGuo in view of its low oxidation potential. This nicely accounts for the fact that the primary oxidation product 8-oxodGuo, which serves as important monitor of oxidative genotoxicity, may not accumulate appreciably in the photooxidation of DNA.
A lower bound for the complexity of information networks for one partial order relation (1996)

Article A lower bound for the complexity of information networks for one partial order relation was published on January 1, 1996 in the journal Discrete Mathematics and Applications (volume 6, issue 6).
Validation of GATE simulations of the <sup>176</sup>Lu intrinsic activity in LSO detectors (2009)

The effects of the intrinsic activity of lutetium-based scintillators such as lutetium oxyorthosilicate (LSO) used in positron emission tomography (PET) imaging have been well documented and is generally not a concern in routine scanning. However, this intrinsic activity can become problematic when using a wide energy window or in low count rate scenarios such as cell trafficking studies in small animal imaging. To date, no systematic validation of Monte Carlo simulations of the intrinsic <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">176</sup> Lu activity has been performed, making it difficult to incorporate them into the design and simulation of proposed scanners. This study seeks to validate Geant4 Application for Tomographic Emission (GATE) simulations of the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">176</sup> Lu intrinsic activity in LSO based detectors against data gathered from a pair of LSO-based Siemens Inveon detectors. Measurements from two opposing detector modules were acquired using NIM electronics and a PC based data acquisition (DAQ) card. The detectors were characterized by determining the count rate due to intrinsic coincidence events vs. detector separation while stepping the lower level discriminator (LLD). Monte Carlo simulations were performed using GATE to reproduce the geometry of the bench-top measurements made with the two detectors, modeling the intrinsic activity of the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">176</sup> Lu as an ion source located within the scintillator crystals. Initial measurements show good agreement between the simulated and measured results. Intrinsic coincidence count rates are in good agreement at all distances, diverging when the LLD is stepped to a level near an intrinsic photopeak. The bench-top setup results require minor refinement to improve the accuracy of measurements at low energy levels which will be done before completing validation of the simulation results.
Ultrashallow Junction Formation Using Low-Temperature Selective Si<sub>1-x</sub>Ge<sub>x</sub> Chemical Vapor Deposition (1994)

In situ B doping and selective epitaxy on Si at 550° C in Si 1- x Ge x chemical vapor deposition (CVD) have been investigated for forming high-performance ultrashallow junctions. It was found that the incorporation rate of B increased proportionally with increasing B 2 H 6 partial pressure, and was higher for the film with a higher Ge fraction x . Using Si 3 N 4 , thermal SiO 2 , phosphosilicate glass (PSG) and borophosphosilicate glass (BPSG) as mask film materials, about 40-nm-, 100-nm-, 150-nm- and 150-nm-thick B-doped Si 0.5 Ge 0.5 films, respectively, were grown selectively on Si(100). Using this low-temperature selective Si 1- x Ge x CVD, a high-performance self-aligned ultrashallow junction formation has been achieved with a very low reverse current density, in the range of 10 -10 A/cm 2 , without heat treatment.
Comparison of Different RFX Operation Modes (1995)

The results obtained in operating the RFX reversed field pinch experiment up to a plasma current of 0.8 MA are reported. Different reversed field pinch setting-up methods are discussed. The effect on energy confinement of control of the plasma column equilibrium, of the field errors at the gaps and of the impurities by means of boronization is described. In the best conditions, a constant be (> 10%) has been observed in the current range so far explored.
Synthesis of the C-13 Side Chain Precursors of the 9-Dihydrotaxane Analogue ABT-271 (2000)

N-Boc-L-Leucinol was converted to two C-13 side chain precursors of the 9-dihydrotaxane analogue ABT-271. The trans-oxazolidine acid 4 and the cis-Boc-lactam 2b were prepared in 44% and 40% overall yield, respectively, and with excellent (>98%) stereochemical purity.
Pseudoalteromonas tunicata sp. nov., a bacterium that produces antifouling agents (1998)

A dark-green-pigmented marine bacterium, previously designated D2, which produces components that are inhibitory to common marine fouling organisms has been characterized and assessed for taxonomic assignment. Based on direct double-stranded sequencing of the 16S rRNA gene, D2T was found to show the highest similarity (93%) to members of the genus Pseudoalteromonas. The G + C content of D2T is 42 mol%, and it is a facultatively anaerobic rod and oxidase-positive. D2T is motile by a sheathed polar flagellum, exhibited non-fermentative metabolism and required sodium ions for growth. The strain was not capable of using citrate, fructose, sucrose, sorbitol and glycerol but it utilizes mannose and maltose and hydrolyses gelatin. The molecular evidence, together with phenotypic characteristics, showed that this bacterium which produces an antifouling agent constitutes a new species of the genus Pseudoalteromonas. The name Pseudoalteromonas tunicata is proposed for this bacterium, and the type strain is D2T (= CCUG 26757T).
Study on Data Processing of a Teaching Robot with Redundant Degrees-of-Freedom. (1995)

Shape data input of an industrial art object can be easily performed by using a teaching robot. The objective of this research is to reduce the random errors in the teaching data and to obtain smooth curved lines and surfaces. By this, 3D graphic expression and machining of an industrial art object can be made easy. For characteristic lines, the least square method is used to fit a polynomial expression. For curved surfaces, two parameters (ui, vi) for expressing surface are used, and the teaching data are sorted with respect to these parameters. The least square method is then used to fit polynomial expressions on the curved surfaces. Finally, the fitted polynomial expressions are used to calculate corrected value of teaching data for generating smooth curved lines and surfaces.
Rotation of two trapped microparticles in vacuum: observation of optically mediated parametric resonances (2015)

We demonstrate trapping and rotation of two mesoscopic particles in vacuum using a spatial-light-modulator-based approach to trap more than one particle, induce controlled rotation of individual particles, and mediate interparticle separation. By trapping and rotating two vaterite particles, we observe intensity modulation of the scattered light at the sum and difference frequencies with respect to the individual rotation rates. This first demonstration of optical interference between two microparticles in vacuum leads to a platform to potentially explore optical binding and quantum friction effects.
Vasculature‐targeted tumor necrosis factor‐alpha increases the therapeutic index of doxorubicin against prostate cancer (2008)

Pre-treatment with NGR-TNF significantly expanded the therapeutic index of doxorubicin in mouse models of hormone-dependent and -independent PC.
Poly(aryl ether benzazole)s (1996)

The aromatic poly(benzimidazoles) (PBI) comprise a class of heterocyclic polymers that show excellent thermal stability (1). The high degree of molecular rigidity in the backbone together with intramolecular interactions produces a high modulus polymer with a variety of applications including fibers and in circuit boards. In spite of these attractive properties, the use of PBIs has been somewhat limited since many are only soluble in strong acids and cannot be processed from organic solvents. Improved solubility and processability has been accomplished by the incorporation of meta substituted linkages, aryl ether linkages and both pendent and main-chain alkyl substituents which can be built into the monomers prior to polymerization. The poly(benzimidazoles) are a subset of the group of poly(benzazoles) which also includes the benzoxazole and benzothiazole heterocycle containing analogs. The PBIs are generally synthesized by the step growth polymerization of an aromatic bis(o-phenylene diamine) with an aromatic diacid (or diacid derivative
Revision Rates in Forefoot Surgery (1982)

In an attempt to determine failure or reoperation rates for common forefoot procedures, the records of 706 patients who had 1003 forefoot operations were studied. The revision rate for the Keller procedure was 2.26% when no interposition implant was used. The revision rate for metatarsal osteotomies, mainly due to nonunion, was 2.7%. The revision rate for proximal phalangectomies was 3.3%, being 1.9% when the distal end of the phalanx was removed and 4.4% when the proximal end was removed. The failure rate for proximal interphalangeal joint fusion was 17.8%. These results demonstrate that the antiquity of a procedure is not necessarily a recommendation.
<title>Novel fringe-scanning/Fourier-transform method of synthetic imaging</title> (1993)

We have developed a one-dimensional theory and a computer model for synthetically imaging scenes using a novel fringe scanning/Fourier transform technique. Our method probes a scene using two interfering beams of slightly different frequency. These beams form a moving fringe pattern which scans the scene and resonates with any spatial frequency components having the same spatial frequency as the scanning fringe pattern. A simple, non-imaging detector above the scene observes any scattered radiation from the scene falling onto it. If a resonance occurs between the scanning fringe pattern and the scene, then the scattered radiation will be modulated at the difference frequency between the two probing beams. By changing the spatial period of the fringe pattern and then measuring the amplitude and phase of the modulated radiation that is scattered from the scene, the Fourier amplitudes and phases of the different spatial frequency components making up the scene can be measured. A synthetic image of the scene being probed can be generated from this Fourier amplitude and phase data by taking the inverse Fourier transform of this information. This technique could be used to image objects using light, ultrasonic, or other electromagnetic or acoustic waves.
Novel ultrafast vertically emitting semiconductor lasers (2010)

We demonstrate the highest average power of any modelocked semiconductor laser: the optically-pumped MIXSEL generates 6.4-W in 28.1-ps pulses at 2.5-GHz repetition rate. Furthermore, we discuss electrically-pumped VECSELs optimized for passive modelocking and present initial cw-lasing with >100-mW.
Enhanced engineering of down timeless system evolution by use of hardware capability descriptions within the &#x003B5;CEDAC approach (2007)

Downtimeless evolution of distributed automation systems (changes during runtime) sets high demands on the underlying concepts and methodologies. Within the εCEDAC project a sophisticated description of the underlying system, including state information as well as capabilities of the hardware, is used. In combination with an engineering tool it offers a great amount of engineering support, thus keeping the complexity manageable. This paper illustrates the application of this technology especially for evolution engineering. Herein, the εCEDAC approach provides a mean for checking the correctness of the process of downtimeless evolution by use of a reconfiguration application.
Protective, Curative, and Eradicant Activity of Difenoconazole Against<i>Venturia inaequalis, Cercospora arachidicola,</i>and<i>Alternaria solani</i> (1992)

The protective and curative activities of difenoconazole against Venturia inaequalis, Cercospora arachidicola, and Alternaria solani were determined in the greenhouse on apple, peanut, and tomato, respectively. In addition, the effects of difenoconazole on established, visible scab lesions and on the production of spores from treated lesions were evaluated. Spray treatments with 12.5 μg a.i/ml of difenoconazole provided 90 and 100% disease control of V. inaequalis following 3 days of protective and 3 days of curative treatments, respectively (.)
Posterosuperior glenoid impingement of the shoulder: findings at MR imaging and MR arthrography with arthroscopic correlation. (1994)

Impingement of the rotator cuff on the posterior superior glenoid labrum is a cause of posterior shoulder pain in athletes who throw. MR arthrography may allow detection of abnormalities associated with this clinical entity.