gebhart/patrepeval huggingface dataset:
Cleavage of SNAP-25 and VAMP-2 impairs store-operated Ca<sup>2+</sup> entry in mouse pancreatic acinar cells (2004)

We recently reported that store-operated Ca(2+) entry (SOCE) in nonexcitable cells is likely to be mediated by a reversible interaction between Ca(2+) channels in the plasma membrane and the endoplasmic reticulum, a mechanism known as "secretion-like coupling." As for secretion, in this model the actin cytoskeleton plays a key regulatory role. In the present study we have explored the involvement of the secretory proteins synaptosome-associated protein (SNAP-25) and vesicle-associated membrane protein (VAMP) in SOCE in pancreatic acinar cells. Cleavage of SNAP-25 and VAMPs by treatment with botulinum toxin A (BoNT A) and tetanus toxin (TeTx), respectively, effectively inhibited amylase secretion stimulated by the physiological agonist CCK-8. BoNT A significantly reduced Ca(2+) entry induced by store depletion using thapsigargin or CCK-8. In addition, treatment with BoNT A once SOCE had been activated reduced Ca(2+) influx, indicating that SNAP-25 is needed for both the activation and maintenance of SOCE in pancreatic acinar cells. VAMP-2 and VAMP-3 are expressed in mouse pancreatic acinar cells. Both proteins associate with the cytoskeleton upon Ca(2+) store depletion, although only VAMP-2 seems to be sensitive to TeTx. Treatment of pancreatic acinar cells with TeTx reduced the activation of SOCE without affecting its maintenance. These findings support a role for SNAP-25 and VAMP-2 in the activation of SOCE in pancreatic acinar cells and show parallels between this process and secretion in a specialized secretory cell type.
Exploring the interaction of <scp>l</scp>-cysteine capped CuS nanoparticles with bovine serum albumin (BSA): a spectroscopic study (2016)

<sc>l</sc>-Cysteine capped copper sulfide nanoparticles with an average particle size of 6 nm were synthesized using a chemical co-precipitation method and their interactions with bovine serum albumin were explored using various spectroscopic techniques.
On continuous control of PWM inverters in the overmodulation range including the six-step mode (1993)

The power output and the dynamic performance of PWM (pulse width modulated) controlled AC motor drives can be improved by increasing the inverter output voltage through overmodulation. Two different solutions are proposed to increase the output voltage in a continuously controllable fashion up to maximum possible value, which is reached in the six-step mode. The solutions differ in their approaches. A space vector strategy is used for high dynamic performance, high switching frequency drives, while a field-oriented PWM method is used for low switching frequency, high power inverters. Experimental results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Topical Sodium Cromoglycate in Atopic Dermatitis A Disappointing but Informative Trial (1986)

Forty children with atopic eczema requiring topical steroids entered a double-blind group comparative study over 12 weeks and were randomized to either 4% sodium cromoglycate (SCG) in an oil-in-water cream or matching placebo cream. The eczema was evaluated on area charts for 20 parts of the body at five clinic visits. In addition, the families kept diaries on symptoms and treatment. After 3 weeks there were small but statistically significant decreases in severity scores recorded at the clinical visits in the SCG group compared with small increases in the placebo group. However, there were no statistically significant differences in the diary card data during the first 3 weeks of treatment or in any other period, nor were significant differences found in any efficacy data collected during the other 9 weeks of the trial. There were no marked differences in treatment opinions, unusual symptoms, skin infections, use of topical steroids or drugs, or acceptability data between the groups. Staphylococcus aureus was found once or twice in cultures from eczema lesions in 31 of 40 children with no marked group difference. The trial showed that there is great need for improved information, family support and topical as well as general treatment in childhood atopic eczema, but topical SCG did not relieve the patients' eczema.
Recombination processes in semiconductors (1959)

Recombination of electrons and holes may take place in the host crystal or at impurity centres, the energy being removed by radiation of a light quantum, by multiphonon emission, or by an Auger process. The probabilities for each of these six processes are discussed. While the lifetime in semiconductors is usually determined by multiphonon recombination at impurity centres, Auger recombination in the host crystal can be expected to dominate in small-band-gap crystals containing large concentrations of free carriers. Radiative recombination in the host crystal may limit the lifetime in semiconductors where band-to-band transitions are direct, provided that the specimens are reasonably free of recombination centres.
Interventions to Minimize Jet Lag After Westward and Eastward Flight (2019)

Air travel across several time zones, i.e., transmeridian flight, causes negative effectsâsome of which occur during flight and some of which occur in the days after flight. Anecdotally, these effects are often referred to collectively as jet lag, but they are actually two separate phenomenaâtravel fatigue and jet lagâeach with their own causes and consequences (Waterhouse et al., 2004). Travel fatigue refers to a collection of symptoms that occur during or immediately after long flights. These symptoms include fatigue, disorientation, and headache (Waterhouse et al., 2004)âprimarily caused by the sleep loss, dehydration, hypoxia, and discomfort associated with being in an aircraft with confined space, recline-restricted seats, low air pressure, low humidity, etc., for 8â14 h (Brown et al., 2001; Roach et al., 2018). In contrast, jet lag refers to a collection of symptoms that occur in the days after flight across three or more time zones. These symptoms include headache, irritability, daytime sleepiness, difficulty sleeping at night, poor mental and physical performance, and poor gastrointestinal function (Waterhouse et al., 2004)âprimarily caused by the mismatch between the circadian system, or internal body clock, which is synchronized to time cues in the departure time zone, and the desired timing of sleep and wake, which are typically synchronized to time cues in the destination time zone. In August 2020, the Olympic Games will be held in Tokyo, Japan. Athletes will travel from all over the world to compete in the Games, and many will have to travel across several time zones. For example, athletes traveling to Japan from North America and Western Europe will face time zone changes of 8â11 h west and 6â8 h east, respectively. Some athletes will travel to Japan, or nearby countries, weeks before their events, while others will arrive in Japan in the days prior to competition. In either case, athletes will want to adjust to the new time zone as quickly as possible so that they can prepare well and/or compete at the highest level. The purpose of this manuscript is to discuss the causes and consequences of jet lag and to provide examples of how to use judiciously timed light exposure/avoidance and/or exogenous melatonin ingestion to adapt the circadian system to a new time zone after transmeridian flight. These guides could be applied by athletes competing in the Tokyo 2020 Olympic Games, but they could also be applied by athletes traveling to other countries for training or competition, or by non-athletes traveling for business or pleasure.
CMOS amplifiers incorporating a novel slew rate enhancement technique (2002)

A novel technique for enhancing the slew rate in CMOS amplifiers is described. The enhancement is provided by an auxiliary circuit which is automatically activated during transients. The main amplifier is not stressed with large currents, thus minimizing power dissipation and avoiding signal swing problems. This technique is quite generic, and can be applied to a variety of amplifier structures. An experimental operational transconductance amplifier incorporating this technique has been fabricated. A slew rate of 1 V/ mu s with a 10000 pF load capacitance has been achieved, while requiring a quiescent power dissipation of less than 1.5 mW.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A knowledge‐based framework for intelligent‐data migration (1996)

Abstract: The Object‐Inferencing Framework (OIF) is a knowledge‐based system developed for intelligent‐data migration. The framework provides a mechanism to integrate relational data which represents a source model; a project‐specific rulebase which specifies plausible migration scenarios; and a deduction system to facilitate the migration of source data to a new, complex target model. Typically, the target model includes constituents that possess both graphic and tabular components. Although the framework is experimental, industrial applications built upon OIF have been successfully deployed in scenarios in which the source data contained implicit information in that semantic relationships and structure conveyed by the data had to be inferred by a domain expert. This framework provides a substrate for migration from any unstructured or semi‐structured data representation to a complex, semantically rich target data model. Examples of the migration of CAD data, which represents an electrical‐distribution system, to a client‐server based Automated Mapping/Facilities Management (AM/FM) platform are presented to convey the salient features of the design and utility of the OIF. Even though the examples are taken from a specific domain, the approach has potential applications in a myriad of domains, including business enterprises in which the migration of data created and managed by legacy systems to object‐oriented and clientserver environments is an area of intense research and development.
Nucleic Acid Sequence Based Amplification (NASBA) of Chlamydia pneumoniae Major Outer Membrane Protein (ompA) mRNA with Bioluminescent Detection (2000)

Chlamydia pneumoniae has been associated with chronic conditions such as atherosclerosis and coronary heart disease but the precise role of this intracellular bacteria in the pathogenesis of these diseases is not well defined. Several techniques have been developed for detection of C. pneumoniae in atheromatous lesions, however it remains unclear whether persistent forms of the organism and/or actively replicating bacteria contribute to associated pathology. The aim of this study was to utilize nucleic acid sequence based amplification (NASBA) technology together with a highly sensitive aequorin bioluminescent hybridization assay for the detection of C. pneumoniae ompA mRNA transcripts. A NASBA targeting the ompA gene of C. pneumoniae was developed, and the sensitivity was evaluated using both C. pneumoniae ompA RNA generated in vitro, and purified C. pneumoniae inclusion forming units (IFU). C. pneumoniae NASBA was capable of detecting between 100 and 1000 ompA RNA molecules and could detect 0.2 IFU of C. pneumoniae using the aequorin bioluminescent assay. The sensitivity of the bioluminescent assay was at least 10-fold higher than Northern blot detection. The linearity of NASBA amplification was assessed in time-course amplification experiments with different input numbers of RNA molecules. When NASBA products were analyzed during the linear phase of amplification, the dynamic range of bioluminescent detection extended over 8-log units of input RNA copy number. NASBA amplification coupled with bioluminescent detection may prove to be a useful molecular tool for the detection, quantitation and analysis of differentially expressed chlamydial genes during various stages of infection and disease pathology or for other mRNAs of interest in different disease processes.
Synthesis and solvolysis of syn- and anti-(6-oxabicyclo[3.1.0]hex-3-yl)methyl p-bromobenzenesulfonates (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and solvolysis of syn- and anti-(6-oxabicyclo[3.1.0]hex-3-yl)methyl p-bromobenzenesulfonatesFeeya DavidCite this: J. Org. Chem. 1981, 46, 17, 3512–3519Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/jo00330a027https://doi.org/10.1021/jo00330a027research-articleACS PublicationsRequest reuse permissionsArticle Views485Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An access control model for multi-level security in multi-domain networking environments (2017)

Access control is important to protect the network security. The increasing demand for secure interactions between network domains brings in new challenges to access control technologies. In this paper we design an access control model which provides a multilevel mapping method between hierarchical access control structures for achieving multilevel security protection in multi-domain networking environments. Hierarchical access control structures ensure rigorous multilevel security in intra domains. And the mapping method based on quantized subject attributes is proposed to determine the subject's security level in its target domain. Credibility is used in the model to adjust the mapping value in order to achieve flexible multilevel inter-domain access control. Experimental results we obtained from simulations are also reported in this paper to verify the effectiveness of the proposed access control model.
Phonological Coding, Phonological Awareness, and Reading Ability: Evidence from a Longitudinal and Experimental Study. (1987)

Two studies are reported that provide correlational and experimental evidence for causal relationships between linguistic coding deficits and reading disability. Convergent evidence of three different types is presented as documentation that deficiencies in phonological coding and phonemic segmentation are a direct cause of deficiencies in word identification: (a) evidence from a longitudinal study demonstrating the predictive validity of phonemic segmentation ability, (b) evidence from a training study demonstrating that training in phonemic segmen tation and alphabetic mapping had a salutary effect on a task simulating word identification and code acquisition, and (c) evidence from normal and poor read ers, matched for reading ability, demonstrating comparable levels of perfor mance on a large number of tasks presumed to be highly dependent on phonol ogical coding ability. It was concluded that phonologic coding deficits constitute a major source of reading difficulty in beginning readers, although there was suggestive evidence that semantic and syntactic deficits also may cause such dif ficulty.
Molecular-dynamics simulation of the smectic-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi>A</mml:mi></mml:mrow><mml:mrow><mml:mi>*</mml:mi></mml:mrow></mml:msup></mml:mrow></mml:math>twist grain-boundary phase (1998)

In this paper we present the results of extensive molecular-dynamics simulations of a model of liquid crystals, in which a twist is imposed on the direction of preferred orientation. On quenching the system from a twisted nematic phase to a state point within the smectic-$A$ phase, we observe a structure which corresponds closely to that of the smectic-${A}^{*}$ twist grain-boundary phase. We investigate this structure by means of director and structure factor profiles, and also develop a technique for automatically locating screw dislocations. Applying this technique to the configurations from our simulations, we obtain a defect distribution which is in qualitative agreement with theoretical predictions.
A New EEG Acquisition Protocol for Biometric Identification Using Eye Blinking Signals (2015)

In this paper, a new acquisition protocol is adopted for identifying individuals from electroencephalogram signals based on eye blinking waveforms. For this purpose, a database of 10 subjects is collected using Neurosky Mindwave headset. Then, the eye blinking signal is extracted from brain wave recordings and used for the identification task. The feature extraction stage includes fitting the extracted eye blinks to autoregressive model. Two algorithms are implemented for autoregressive modeling namely; Levinson-Durbin and Burg algorithms. Then, discriminant analysis is adopted for classification scheme. Linear and quadratic discriminant functions are tested and compared in this paper. Using Burg algorithm with linear discriminant analysis, the proposed system can identify subjects with best accuracy of 99.8%. The obtained results in this paper confirm that eye blinking waveform carries discriminant information and is therefore appropriate as a basis for person identification methods.
Development of Inverse Radiative Method for Measuring Gaseous and Particles Concentrations in the Exhaust Plumes by Using Remote Sensing Method (2005)

An algorithm was developed to predict the attenuation coefficient of the medium containing an exhaust gas mixture with soot particles. The absorption and scattering efficiencies of the particles were calculated according to Mie or Rayleigh theories, and the absorption coefficients by the Line-by-Line (LBL) method. Analytical solutions to the GDE were obtained previously for particles number concentrations. Theoretical and measurement results were presented here for the gaseous pollutants mole fractions. RS experiments were carried out, where emissions of about 20,000 vehicles were measured. Numerical results (for optical thickness) of the present model compare favorably with experimental data. It was shown that the theoretical results are similar to the measured results for large CO mole fractions, when the IR radiation (at 1.565 µm wavelength) absorption is strong. This algorithm may be applied in the current RS technologies as a supplement tool for monitoring Particulate Matter (PM). Nomenclature b = Parameter in Gamma distribution , m 1 . c = Speed of light, sec m . d = Particle diameter, m. p D = Diffusion coefficient of particles, sec m 2 . () i
Next generation material failure model for impact analysis (2016)

Current practice in crash analysis on maritime structures uses rupture strain as a single parameter failure criterion. The criterion assumes a plane strain condition irrespective of the actual stress state. However ship and offshore structures, exposed to actual collisions or groundings may well deform in different ways and exhibit other strain conditions where the material tends to develop strains in two directions and such strains may be significantly larger. The current failure criterion is therefore conservative and does not do justice to the actual structural capacity to withstand impact loads.
Piezoelectric-based energy-harvesting power sources for gun-fired munitions (2006)

This paper presents a new class of piezoelectric based energy harvesting power sources for use in gun-fired munitions or other similar applications requiring high G survivability . These power sources are designed to harvest energy from the firing acceleration as well as vibratory motion and spinning of munitions during their flight and convert it to electrical energy that could be used directly by power consuming electronics onboard munitions or stored. The power sources are designed to withstand firing accelerations in excess of 100,000 G. The power sources have been shown to have the potential of completely eliminating the need for chemical batteries in many fuzing applications, while having the added advantage of providing for considerably more safety and long shelf life. Prototypes of a number of designs of this class of energy harvesting power sources for various power requirements have been constructed and successfully tested in the laboratory and by the U. S. Army (ARDEC) using air guns.
Effects of different metal ions on the fluorescence of CdSe/ZnS quantum dots capped with various thiolate ligands (2013)

In this report, we systematically studied the effects of different metal ions on the fluorescence of common thiolate ligand capped quantum dots. Generally, heavy metal ions exhibited much more significant fluorescence quenching. Also, the coordination capability and steric hindrance of the ligand jointly affect the quenching efficiency.
Performance Profiling of Embedded ConvNets under Thermal-Aware DVFS (2019)

Convolutional Neural Networks (ConvNets) can be shrunk to fit embedded CPUs adopted on mobile end-nodes, like smartphones or drones. The deployment onto such devices encompasses several algorithmic level optimizations, e.g., topology restructuring, pruning, and quantization, that reduce the complexity of the network, ensuring less resource usage and hence higher speed. Several studies revealed remarkable performance, paving the way towards real-time inference on low power cores. However, continuous execution at maximum speed is quite unrealistic due to a fast increase of the on-chip temperature. Indeed, proper thermal management is paramount to guarantee silicon reliability and a safe user experience. Power management schemes, like voltage lowering and frequency scaling, are common knobs to control the thermal stability. Obviously, this implies a performance degradation, often not considered during the training and optimization stages. The objective of this work is to present the performance assessment of embedded ConvNets under thermal management. Our study covers the behavior of two control policies, namely reactive and proactive, implemented through the Dynamic Voltage-Frequency Scaling (DVFS) mechanism available on commercial embedded CPUs. As benchmarks, we used four state-of-the-art ConvNets for computer vision flashed into the ARM Cortex-A15 CPU. With the collected results, we aim to show the existing temperature-performance trade-off and give a more realistic analysis of the maximum performance achievable. Moreover, we empirically demonstrate the strict relationship between the on-chip thermal behavior and the hyper-parameters of the ConvNet, revealing optimization margins for a thermal-aware design of neural network layers.