gebhart/patrepeval huggingface dataset:
Mutations in the carcinoembryonic antigen gene in colorectal cancer patients: implications on liver metastasis. (2001)

Carcinoembryonic antigen (CEA) expression is used clinically to monitor patients with colorectal and other cancers. A subset of patients have extraordinarily high CEA levels that cannot be attributed solely to tumor load. We have shown mutations in the region of CEA (PELPK motif) responsible for its hepatic clearance in three of eight patients with high CEA levels. We used denaturing high-performance liquid chromatography to provide evidence of polymorphism in these patients. These mutations were scored by DNA cycle sequencing and shown to be heterozygous. The patients with mutations in the PELPK motif showed remarkably reduced circulatory clearance rates in an animal model. A patient without mutation in the region showed normal clearance rates. Mutations in PELPK may affect structural stability and binding affinity to the Kupffer cell receptor in the liver. These studies have implications for the role of CEA as a facilitator of hepatic metastasis.
Precision polymers: a kinetic approach for functional poly(norbornenes) (2014)

Control over monomer sequence in the ring-opening metathesis polymerization of functional norbornenes is explored based on the difference in reactivity of <italic>endo</italic> and <italic>exo</italic> isomers.
<title>Requirements for calibration of focal plane arrays for imaging spectrometers</title> (1998)

Recently a new class of instruments, that uses a detector array to measure spectra for multiple points on the ground, has become available. These instruments build up an image by a pushbroom technique. The realization of the maximum potential of these Array Imaging Spectrometers is dependent on the ability to correct pixel to pixel variations in gain, bias, dark current and linearity of the detector array. Residual calibration striping in each band along the temporal axis, is usually the limiting noise source in these sensors, not photon or system electronic noise. Indeed, performance calculations or measurements which do not take this important noise source into account seriously overestimate the performance of Array Imaging Spectrometers. In this paper, the calibration requirements for Array Imaging Spectrometers, in general, and the procedure used to calibrate the Airborne Hyperspectral Imager (AHI) will be discussed. Examples from the Airborne-Hyperspectral Imager (AHI) will be used to illustrate the residual error and characterize its effect.
Parallel DNA: generation of a duplex between two <i>Drosophila</i> sequences in vitro (1989)

We have observed the existence of a parallel complementary region between two Drosophila DNA sequences, fragments of the suffix [(1986) EMBO J, 5, 2341-2347] and a 5'-non-coding sequence of the alcohol dehydrogenase gene [(1983) Cell 33, 125-133]. The region includes approximately 40 bp, 76% of which are complementary in the same polarity. Synthetic complementary 16 bp oligonucleotides corresponding to this region which were bound by the 5'-ends through a 1.6-hexanediol bridge form a duplex which displays both melting and annealing as judged by UV absorbance. Anti parallel complementary 16 bp long oligonucleotides bound by the 5'-3' ends through the same bridge and a single-strand sequence were used as controls. The Hoechst 33,258 drug binds to this parallel duplex of DNA; however, the properties of such a complex testify against the B-form of the duplex.
Improving Attention to Security in Software Design with Analytics and Cognitive Techniques (2017)

There is widening chasm between the ease of creating software and difficulty of "building security in". This paper reviews the approach, the findings and recent experiments from a seven-year effort to enable consistency across a large, diverse development organization and software portfolio via policies, guidance, automated tools and services. Experience shows that developing secure software is an elusive goal for most. It requires every team to know and apply a wide range of security knowledge in the context of what software is being built, how the software will be used, and the projected threats in the environment where the software will operate. The drive for better outcomes for secure development and increased developer productivity led to experiments to augment developer knowledge and eventually realize the goal of "building the right security in".
The Mechanism of TBD-Catalyzed Ring-Opening Polymerization of Cyclic Esters (2007)

Triazabicyclodecene (TBD) has recently been shown to be an effective organocatalyst for the ring-opening polymerization (ROP) of cyclic esters. Using DFT methods, we have studied possible mechanisms of this reaction. Our studies explain not only the narrow polydispersity index (PDI) observed in the ROP of six-membered ring lactones, but also the surprising failure of the ROP for the more reactive butyrolactone.
A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis. (1996)

Several members of the rho/rac family of small GTP-binding proteins are known to regulate the distribution of the actin cytoskeleton in various subcellular processes. We describe here a novel rac protein, racE, which is specifically required for cytokinesis, an actomyosin-mediated process. The racE gene was isolated in a molecular genetic screen devised to isolate genes required for cytokinesis in Dictyostelium. Phenotypic characterization of racE mutants revealed that racE is not essential for any other cell motility event, including phagocytosis, chemotaxis, capping, or development. Our data provide the first genetic evidence for the essential requirement of a rho-like protein, specifically in cytokinesis, and suggest a role for these proteins in coordinating cytokinesis with the mitotic events of the cell cycle.
The Biology of Scar Formation (1989)

Scar, our body's "glue," is formed through a highly organized sequence of physiologic events. The ability of one type of collagenous tissue to weld various tissues, adapt to their structural integrity, impart tensile strength, and permit return of function is reviewed. A knowledge of wound healing enables the clinician to design and implement treatment strategies based on scar biology. The purposes of this overview are 1) to address the three phases of repair (inflammatory, fibroplastic, and remodeling), 2) to discuss the cellular processes occurring in each phase, 3) to review appropriate intervention methods based on research findings, and 4) to describe complications that interfere with normal healing.
The Grignard Reagents of p- and m-Bromophenylferrocene<sup>1a</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Grignard Reagents of p- and m-Bromophenylferrocene1aWilliam F. Little, Allen K. Clark, Gereld S. Benner, and Cheryl NoeCite this: J. Org. Chem. 1964, 29, 3, 713–714Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/jo01026a046https://doi.org/10.1021/jo01026a046research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Accurate strain measurements with fiber Bragg sensors and wavelength references (2006)

Fiber Bragg grating (FBG) sensors are one of many fiber optic sensor technologies that are currently being used in structural health monitoring systems. The sensors operate by detecting a shift in the wavelength of the reflected maxima due to applied strain. This paper studies a new fiber Bragg interrogation method that combines a swept wavelength laser in combination with wavelength references. These include a gas cell which is used as the long term wavelength standard and an etalon used for accurate interpolation of peak wavelengths. An etalon is essentially a filter that has a periodic response over a broad wavelength range. Since its wavelength response spacing is smaller than the gas cell, it can be used to determine the intermediate wavelengths between two gas cell absorption lines. Peak location is a key element of this interrogation method and several detection algorithms are investigated. It was determined that polynomial peak fitting is the most computationally efficient method and yields a resolution of better than 0.5 pm with signal to noise ratios of 30:1 or better. With higher signal to noise ratios, polynomial peak fitting can yield a resolution of better than 0.25 pm. Using a tunable laser, a hydrogen cyanide (HCN) gas cell and an etalon with maxima every 140 pm, static load tests have demonstrated a resolution of 1 pm and an accuracy of less than 5 pm. Also, this accuracy will be maintained over a long period of time as it is based on absorption lines in the gas cell. The results of this study demonstrate that absolute accurate strain measurements can be obtained with the use of wavelength references in conjunction with a suitable peak location algorithm.
Darstellung der Störerhaftung (2003)

Die Darstellung der öffentlich-rechtlichen Störerhaftung hat zum Zweck, die — für eine ökonomische Analyse relevanten — Voraussetzungen und Folgen dieser Haftung herauszuarbeiten.
Computer control of a Class-E amplifier (1988)

High frequency electrical power supplies used in many industrial applications have to be able to withstand appreciable variations in load impedance. This paper describes the use of a computer to control a Class-E amplifier power supply which is being developed for high frequency induction and dielectric heating applications.
Development of an integrated network manager for heterogeneous networks using OSI standards and object-oriented techniques (1994)

The Federal Aviation Administration (FAA) is using an increasing number of interconnected, heterogeneous telecommunications networks. The FAA is looking at new ways of automating the operations and maintenance activities of these networks in a cost-effective manner in a rapidly changing environment. Open system interconnection (OSI) standards provide a structure for dealing with multivendor systems and network management problems, including mechanisms for monitoring, controlling, and coordinating resources, as well as protocol standards for communicating information about these resources. An example of a standards-based open system for network and services management is a prototype system being developed by the Center for Advanced Aviation System Development (CAASD) and the FAA for managing telecommunications networks and services at Air Route Traffic Control Centers (ARTCCs). This system, the Telecommunications ARTCC Prototype (TAP), is being developed to integrate the various existing communications management capabilities at the ARTCC into a single management system. Following OSI standards and object-oriented techniques provides a concept and structure for a distributed management architecture. The syntax and semantics for management information and functions specified in the standards provide an understanding and definition of the operations to be performed and the information to be collected and communicated. The paper provides an overview of the prototype architecture, describes how OSI standards and object-oriented techniques were applied and interpreted to meet the specific requirements of the ARTCC.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Spring Virtual Memory System, The (1993)

: In this document we describe the architecture and the implementation of the Spring virtual memory system. The architecture separates the tasks of maintaining memory mappings and protections from the task of paging memory in and out of backing store. A per-node virtual memory manager is responsible for maintaining the mappings on the local machine while external pagers are responsible for managing backing store. A novel aspect of the architecture is the separation of the memory abstraction from the interface that provides the paging operations. The design supports flexible memory sharing, sparse address spaces, and copy-on-write mechanisms. Support for distributed shared memory and extensible stackable file systems are natural consequences of the design. The architecture is implemented and has been in use for over two years as part of an experimental operating system. Categories and Subject Descriptors: D.4 Software: [Operating Systems]: D.4.2 Storage management D.4.3 File systems ...
Polysaccharides-Rich Extract of<i>Ganoderma lucidum</i>(M.A. Curtis:Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats (2013)

Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound healing effects of G. lucidum were partly attributed to its rich polysaccharides. However, little attention has been paid to its potential effects on wounds associated with diabetes mellitus. In this study, we evaluated the wound healing activity of the hot aqueous extract of G. lucidum in streptozotocin-induced diabetic rats. The extract of G. lucidum was standardised based on chemical contents (w/w) of total polysaccharides (25.1%), ganoderic acid A (0.45%), and adenosine (0.069%). Six groups of six rats were experimentally wounded in the posterior neck region. Intrasite gel was used as a positive control and aqueous cream as the placebo. Topical application with 10% (w/w) of mushroom extract-incorporated aqueous cream was more effective than that with Intrasite gel in terms of wound closure. The antioxidant activity in serum of rats treated with aqueous extract of G. lucidum was significantly higher; whereas the oxidative protein products and lipid damage were lower when compared to those of the controls. These findings strongly support the beneficial effects of standardised aqueous extract of G. lucidum in accelerating wound healing in streptozotocin-induced diabetic rats.
Design and Implementation of a Data Compression Scheme: A Partial Matching Approach (2006)

Data compression is an essential process due to the need to reduce the average time required to send messages and reduce the data size for storage purposes. There is a vital need for lossless compression especially for text and binary compression because it is important to ensure that the restructured text is identical to the original text. The predictive by partial matching (PPM) data compression scheme has set the performance standard in lossless compression throughout the past decade. PPM is chosen as it is capable of very good compression on a variety of data. In this paper, we present the realization of data compression using PPM on Altera FLEX10K FPGA device that allows for efficient hardware implementation. The PPM algorithm for binary data compression was successfully written and modeled in VHDL. The design is followed by the timing analysis and circuit synthesis for the validation, functionality and performance of the designated circuit which supports the practicality, advantages and effectiveness of the proposed hardware realization for the application. The designed was verified using both 16- bit input and 32-bit input. The hardware prototype utilized 1164 logic cells with a maximum system frequency of 95.3MHz.
Thermodynamic analysis of the interaction of the antibiotic teicoplanin and its aglycone with cell-wall peptides (1990)

The thermodynamics of the interaction of the glycopeptidic antibiotic teicoplanin and its peptidic moiety with analogues of bacterial cell-wall peptides were studied by means of calorimetric and spectrophotometric techniques. The analysis of the thermodynamic data has allowed us to evaluate the contributions of the different peptide groups to the binding process. The nature of the primary binding forces is also discussed for each interacting group, on the basis of their enthalpic and entropic contribution and in connection with the detailed structural information available for these antibiotics from n.m.r. data. Similar analyses for the case of vancomycin and ristocetin are also reported.
S-band MMIC 6-bit phase shifter (2008)

This paper describes the first pass design and measurements results of a single chip, 6-bit phase shifter. This phase shifter exhibits good VSWR, quite low insertion loss with low variation and correct phase performance over all 64 states across the entire 3-3.6 GHz band. Moreover, the design assures high level of P1dB and good stability with regard to temperature variation.
INFLUÊNCIA DE DIFERENTES ALTURAS NAS CARACTERÍSTICAS FISICO-QUÍMICAS DA CAMA E NA PREVALENCIA DE Salmonella sp. EM SUÍNOS DURANTE A TERMINAÇÃO (2009)

Este trabalho avaliou dois lotes consecutivos de suínos criados em piso de concreto e sobre cama com duas diferentes profundidades. Avaliaram-se os parâmetros ambientais da edificação, físico-químicos da cama, além da presença de Salmonella sp. nos sistemas de piso e nos animais no momento do abate. Os tratamentos foram constituídos de duas profundidades diferentes de cama de casca de arroz, 0,5 m (T1) e 0,25 m (T2), e um sistema com piso compacto de concreto (T3). Utilizaram-se trinta animais, sendo quinze animais por repetição. Registrou-se a temperatura na superfície dos pisos e centro das baias nos três tratamentos, à meia profundidade no centro das baias para T1 e T2. Mensuraram-se a temperatura ambiente e a umidade relativa do ar no interior das baias. Foram determinados pH, teor de matéria seca, carbono e nitrogênio das camas. A análise de Salmonella spp. foi feita em: fezes, sangue, cama, swab do piso e animais no momento do abate. A utilização de piso com cama para suínos nas fases de crescimento-terminação, independente da altura, é viável, pois não influenciou os parâmetros de conforto térmico e a prevalência de salmonela, além de permitir a transformação dos dejetos em material estabilizado para uso agrícola. PALAVRAS-CHAVES: Conforto térmico, meio ambiente, segurança alimentar, sistema de produção.
Spacewar3D: Meshes and Buffers and Textures, Oh My! (2004)

So far, this book has focused on simple 2-D graphics in order to help you build the foundation knowledge you need to move into 3-D gaming. This chapter will now take you from the "flatland" of the original Spacewar game into the third dimension (see Figure 6-1). You'll be introduced to many new concepts, but many of the classes from the Spacewar game will carry over directly into the 3-D version with little or no modification.KeywordsCollision DetectionRender MethodCamera ModeWorld SpaceKeyboard InputThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Alveolar epithelial type II cell: defender of the alveolus revisited (2001)

In 1977, Mason and Williams developed the concept of the alveolar epithelial type II (AE2) cell as a defender of the alveolus. It is well known that AE2 cells synthesise, secrete, and recycle all components of the surfactant that regulates alveolar surface tension in mammalian lungs. AE2 cells influence extracellular surfactant transformation by regulating, for example, pH and [Ca2+] of the hypophase. AE2 cells play various roles in alveolar fluid balance, coagulation/fibrinolysis, and host defence. AE2 cells proliferate, differentiate into AE1 cells, and remove apoptotic AE2 cells by phagocytosis, thus contributing to epithelial repair. AE2 cells may act as immunoregulatory cells. AE2 cells interact with resident and mobile cells, either directly by membrane contact or indirectly via cytokines/growth factors and their receptors, thus representing an integrative unit within the alveolus. Although most data support the concept, the controversy about the character of hyperplastic AE2 cells, reported to synthesise profibrotic factors, proscribes drawing a definite conclusion today.
Task scheduling for flexible manufacturing systems based on genetic algorithms (2002)

The authors present a genetic algorithm approach to solving the task scheduling problem in flexible manufacturing systems (FMSs) An FMS is modeled as a collection of m workstations and p automated guided vehicles (AGVs). The FMS completes a task by performing a series of operations through the workstations, and the parts are transported between the workstations by the AGVs. The problem of task scheduling in an FMS can be stated as finding a schedule for the p AGVs among the m workstations such that n tasks can be completed in the shortest time. The genetic algorithm developed uses a reproduction operator and five mutation operators to perform the task scheduling. Computer simulations of the proposed genetic algorithm are also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The relation of cembral vasospasrn to the extent and location of subarachnoid blood visualized by CT scan (1983)

In 41 cases of verified ruptured saccular aneurysm, we prospectively predicted the presence or absence of delayed symptomatic cerebral vasospasm. CT criteria quantifying the extent and location of subarachnoid blood (developed in our previous retrospective study) were used in this prospective series of patients. Twenty-two patients had recognizable subarachnoid clots larger than 3 X 5 mm or layers of blood more than 1 mm thick (measured on reproduced images). In 20 of the 22 patients with severe significant clot or thick layer, severe vasospasm was correctly predicted and localized (2 false positives). In 19 patients with no blood, or diffuse blood, or blood outside the subarachnoid space, the absence of severe vasospasm was correctly predicted in 14 (5 false negatives). All of the false-positive and false-negative cases could be explained by inadequate CT technique. The data indicate that the extent and location of blood in the subarachnoid space determine the severity and location of vasospasm and that patients in jeopardy of developing symptomatic cerebral vasospasm can now be identified. Early preventive measures may now be assessed more accurately.
16K prolactin induces NF-kappaB activation in pulmonary fibroblasts (2002)

The amino-terminal 16 kDa fragment of prolactin (16K PRL) promotes the expression of the inducible isoform of nitric oxide synthase (iNOS) accompanied by the production of nitric oxide (NO) by rat pulmonary fibroblasts. The present study was designed to elucidate whether the mechanism by which 16K PRL promotes iNOS expression involves the activation of nuclear factor-kappa B (NF-kappaB), a key transcription factor for iNOS induction. 16K PRL stimulated DNA-binding activity of NF-kappaB in pulmonary fibroblasts as demonstrated by gel shift assays. Likewise, fluorescence immunocytochemistry showed that 16K PRL promotes nuclear translocation of the p65 subunit of NF-kappaB. Finally, treatment with 16K PRL induced the degradation of the NF-kappaB inhibitor kappaB-beta (IkappaB-beta), and such degradation was prevented by blocking IkappaB-beta phosphorylation. Altogether, these results show that 16K PRL activates NF-kappaB nuclear translocation via the phosphorylation and degradation of IkappaB-beta. These findings are consistent with NF-kappaB being part of the signal transduction pathway activated by 16K PRL to induce iNOS expression.