gebhart/patrepeval huggingface dataset:
A COMPARATIVE STUDY OF VISUOSPATIAL MEMORY AND LEARNING IN ALZHEIMER-TYPE DEMENTIA AND PARKINSON'S DISEASE (1988)

Groups of patients with dementia of Alzheimer type (DAT) and idiopathic Parkinson's disease, together with age and IQ-matched normal controls, were compared on several computerized tests of visuospatial memory and learning. Two different groups of parkinsonian patients were studied: (1) a newly diagnosed group, early in the course of the disease, not receiving medication (NMED PD) and (2) a group later in the course of the disease, receiving medication (MED PD). The DAT and MED PD group were significantly impaired in both spatial and visual pattern recognition memory. The DAT group exhibited a delay-dependent deficit (over 0–16 s) in a delayed matching-to-sample procedure, but were not impaired at simultaneous-matching-to-sample. By contrast, the MED PD group showed delay-independent deficits in the delayed matching-to-sample test and both the MED PD and the NMED PD group were also significantly impaired in simultancous matching. In a form of delayed response test, the subjects were required first to memorize and then to learn the locations of several abstract visual stimuli which varied progressively in number from 1 to 8. The DAT group were severely impaired in this conditional associative learning task. A significant proportion of patients, but none of the controls, in the NMED and MED PD group also failed the test at the levels of 6 or 8 items. There was a significant correlation between the performance on the first trial, memory score in the delayed response task and indices of clinical disability and disease duration in the patients with Parkinson's disease. The results are discussed in terms of the utility of the comparison between DAT and PD in characterizing the nature of the cognitive deficits in these conditions and their relation to those findings from animal neuropsychology which use comparable paradigms.
Performance characteristic of high-speed phase shifter at demand side (2003)

A high-speed phase shifter (HSPS) is proposed to be installed in a distribution line for better voltage regulation performance and other functions instead of the load tap changing transformer (LTC). In the proposed system, the one converter of HSPS is connected with the tertiary winding of three-phase three-winding transformer of the substation or step voltage regulator (SVR) instead of connecting the LTC. The other converter is connected to the series transformer to inject a voltage to the transmission line. The voltage regulation range and the capacity of HSPS have been analyzed theoretically, and the simulations in which the simulation code "PSCAD/EMTDC" is used have been carried out. As a result, it is shown that the voltage regulation range of HSPS is wider than that of LTC even-though the same winding is used, and HSPS is a one of the solution to regulate the voltage of distribution system.
Superinduction of IL-2 gene transcription in the presence of cycloheximide (1991)

Lymphokine production is regulated both at the transcriptional and the posttranscriptional level. To date, it has been shown that the protein synthesis inhibitor cycloheximide (CHX) up-regulates IL-2 expression in T cells by stabilizing its mRNA. In this report we have examined the effect of CHX on IL-2 at the transcriptional level. We have found that CHX has a positive regulatory function in IL-2 transcription, which is dependent on prior activation of this gene. This is not due to posttranslational conversion of inactive NFkB into its active form by CHX, because a clustered mutation in the kB-like sequence in the IL-2 enhancer that abrogates NFkB binding does not affect the up-regulation of IL-2 transcription. These results favor the hypothesis that, in addition to positive factors, negative elements regulate IL-2 transcription. Furthermore, we have tested the effect of CHX on IL-4 and granulocyte-macrophage-CSF transcription of both lymphokines. These results suggest that transcriptional up-regulation by CHX may be specific for IL-2 with respect to lymphokine expression.
Rapid screening for metabolite overproduction in fermentor broths, using pyrolysis mass spectrometry with multivariate calibration and artificial neural networks (1994)

Abstract Binary mixtures of model systems consisting of the antibiotic ampicillin with either Escherichia coli or Staphylococcus auresu were subjected to pyrolysis mass spectrometry (PyMS). To deconvolute the pyrolysis mass spectra, so as to obtain quantitative information on the concentration of ampicilin in the mixtures, partial least squares regression (PLS), principal components regression (PCR), and fully interconnected feedforward artificial neural networks (ANNs) were studied. In the latter case, the weights were modified using the standard backpropagation algorithm, and the nodes used a sigmoidal squsahing funciton. It was found that each of the methods could be used to provide calibration models which gave excellent predictions for the concentrations of ampicillin in samples on which they had not been trained. Furthermore, ANNs trained to predict the amount of ampicilin in E. coli were able to generalise so as to predict the concentration of ampicillin in a S. aureus background, illustrating the robustness of ANNs to rather substantial variations in the biological background. The PyMS of the complex mixture of ampicilin in bacteria could not be expressed simply in terms of additive combinations of the spectra describing the pure components of the mixtures and their relative concentrations. Intermolecular reactions took place in the pyrolysate, leading to a lack of superposition of the spectral components and to a dependence of the normalized mass spectrum on sample size. Samples from fermentations of a single organism in a complex production medium were also analyzed quantitatively for a drug of commercial interest. The drug could also be quantified in a variety of mutant‐producing strains cultivated in the same medium. The combination of PyMS and ANNs constitutes a novel, rapid, and convenient method for exploitation in strain improvement screening programs. © 1994 John Wiley & Sons, Inc.
Ethanol Feeding Alters Death Signaling in the Pancreas (2006)

Our findings show effects of ethanol on the expression of several signals involved in cell death in the pancreas through alteration of transcriptional regulators. The decrease in caspase expression and increase in cathepsin B expression indicate that ethanol feeding may prevent apoptosis and promote necrosis of pancreatic tissue with stresses that cause pancreatitis.
Two Electron Models of a Constant-Frequency Relativistic Cyclotron (1956)

Two model constant-frequency cyclotrons based on the principle of L. H. Thomas, as extended by David L. Judd, are described. Both accelerated electrons to speeds of half that of light in magnetic fields of three-fold azimuthal periodicity. Three 60°-wide wedge-shaped electrodes, driven 120° out of phase, provided an energy gain per revolution of 3 eV0, where V0 is the peak electrode-to-ground voltage. Electrons were accelerated to 75 kv with V0=23 v, implying a minimum of one thousand revolutions in the cyclotron. The beam reached full energy without axial loss and it was demonstrated that essentially all of the circulating current will emerge from this type of accelerator without the use of additional deflecting systems. The success of this development program has shown the feasibility of a high-current, high-energy cyclotron based on the Thomas principle.
Spin‐dependent type‐II band alignment and carrier spin dynamics in a diluted magnetic double quantum well (2006)

We study spin-dependent type-II band alignment and the carrier spin dynamics in a diluted magnetic double quantum well (DQW) composed of a magnetic well (MW) of Zn0.70Cd0.22Mn0.08Se and a Zn0.76Cd0.24Se non-magnetic well (NMW). In this DQW structure, a heavy-hole (hh) level in the MW intersects that in the NMW by applying a magnetic field of 1 T, resulting from the giant Zeeman effect of the hh in the MW. This hh-level crossing induces a type-II band alignment for the spin-polarized hh in the MW and an electron in the NMW. The circularly polarized photoluminescence (PL) energy decreases and the PL lifetime increases simultaneously with an increase in the magnetic field, which is quantitatively explained by the formation of spin-polarized indirect exciton. The magnetic-field dependence of the exciton PL shows the hh-spin dynamics in the transformation from the direct exciton state to indirect one. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch Syndrome fibroblasts (2020)

ABSTRACT Recently, mutations in the RNA polymerase III subunit 3A (POLR3A) have been described as the cause of the neonatal progeria or Wiedemann-Rautenstrauch syndrome (WRS). POLR3A have important roles in the regulation of transcription of small RNAs, including tRNA, 5S rRNA and U6 snRNA. We aim to describe cellular and molecular features of WRS fibroblasts. Cultures of primary fibroblasts from one WRS patient [monoallelic POLR3A variant c.3772_3773delCT (p.Leu1258Glyfs*12)] and one control were grown. Mutation in POLR3A causes a decreased in the expression of POLR3A mRNA and protein and a sharp increased of mutant protein. In addition, there was an increased in its nuclear localization. These changes were associated to an increase number and area of nucleoli, a significantly larger nuclear area, and a high increased in the expression of pP53 and pH2AX. All these changes were associated to premature senescence. The present observations add to our understanding of the differences between HGPS and WRS, and opens new alternatives to study cell senesce and human aging.
The Influence of Flame, Corona and Atmospheric Plasma Treatments on Surface Properties and Digital Print Quality of Extrusion Coated Paper (2010)

Polymer and paper structures have been successfully utilized in several fields, especially in the packaging industry. Together with barrier properties, printability is an important property in packaging applications. From the point of view of printing, the dense and impervious structure of extrusion coatings is challenging. Flame, corona and atmospheric plasma treatments were used to modify the surface of low density polyethylene (LDPE) and polypropylene (PP) and the influence of these surface modifications on print quality, i.e., toner adhesion and visual quality was studied. The traditional surface treatment methods, i.e., flame and corona treatments, increased the surface energy by introducing oxygen containing functional groups on the surfaces of LDPE and PP more than helium and argon plasma treatments. Only in the case of flame treatment, the higher surface energy and oxidation level led to better print quality, i.e., toner adhesion and visual quality, than the plasma treatments. The morphological changes observed on LDPE surface after flame treatment are partly responsible for the improved print quality. Atmospheric plasma treatments improved the print quality of LDPE and PP surfaces more than corona treatment. The electret phenomenon observed on LDPE and PP surfaces only after corona treatment is the most likely reason for the high print mottling and low visual quality of corona treated surface.
Z-scan simulations on metallodielectric stacks with nonlinear absorption (2011)

Experimental investigations reveal significant nonlinear responses from metallodielectric stacks (MDSs) with constituent metal films of silver (Ag), gold (Au) or copper (Cu). In particular, the Cu dielectric MDS exhibited large non-linear absorption. Nevertheless, there is a need to investigate these materials with more faithful numerical techniques in order to account for the underlying physical processes observed in the experiments. We apply a Finite Element Method (FEM) with radial symmetry to numerically solve for the Z-scan experiment of a MDS using the corresponding nonlinear Maxwell equations. The amplitude and the phase of the electromagnetic field at the exit interface of the MDS are used for transforming to the far-field regime.
Suppression of Urokinase Expression and Invasiveness by Urinary Trypsin Inhibitor Is Mediated through Inhibition of Protein Kinase C- and MEK/ERK/c-Jun-dependent Signaling Pathways (2001)

Urinary trypsin inhibitor (UTI), a Kunitz-type protease inhibitor, interacts with cells as a negative modulator of the invasive cells. Human ovarian cancer cell line, HRA, was treated with phorbol ester (PMA) to evaluate the effect on expression of urokinase-type plasminogen activator (uPA), since the action of uPA has been implicated in matrix degradation and cell motility. Preincubation of the cells with UTI reduced the ability of PMA to trigger the uPA expression at the gene level and at the protein level. UTI-induced down-regulation of PMA-stimulated uPA expression is irreversible and is independent of a cytotoxic effect. Down-regulation of uPA by UTI is mediated by its binding to the cells. We next asked whether the mechanism of inhibition of uPA expression by UTI was due to interference with the protein kinase C second messenger system. An assay for PKC activity demonstrated that UTI does not directly inhibit the catalytic activity of PKC and that PMA translocation of PKC from cytosol to membrane was inhibited by UTI, indicating that UTI inhibits the activation cascade of PKC. PMA could also activate a signaling pathway involving MEK1/ERK2/c-Jun-dependent uPA expression. When cells were preincubated with UTI, we could detect suppression of phosphorylation of these proteins. Like several types of PKC inhibitor, UTI inhibited PMA-stimulated invasiveness. We conclude that UTI markedly suppresses the cell motility possibly through negative regulation of PKC- and MEK/ERK/c-Jun-dependent mechanisms, and that these changes in behavior are correlated with a coordinated down-regulation of uPA which is likely to contribute to the cell invasion processes.
Multiple cracks in VTI rocks: Effective properties and fracture characterization (2007)

Abstract The existing fracture-characterization techniques are based on assuming the unfractured host rock either to be isotropic or the magnitudes of both the background and crack-induced anisotropies to be small. I relax both assumptions and examine the effective media caused by fractures with realistic (not small) crack densities in a strongly anisotropic, primarily transversely isotropic (TI) host rock. The analysis of penny-shaped cracks in the noninteraction approximation (NIA) reveals the dependence of their excess fracture compliance tensors on the orientation of the background symmetry axis. As a result of this dependence, the excess fracture compliance tensor generally becomes rotationally noninvariant even when the cracks are circular. One of the consequences of this complication (compared to the background isotropy) is a reduction of symmetry from TI to monoclinic resulting from the presence of a single oriented fracture set. Verti–cal dry cracks in a vertically transversely isotropic (VTI) host constitute an important exception to this general rule. The effective symmetry for this arrangement is approximately orthorhombic (or orthotropic) even in the presence of multiple fracture sets that have arbitrary azimuths. I perform finite-element simulations on the so-called digital rocks to verify both the proximity of effective symmetry to orthotropy and the accuracy of the NIA up to the crack density of 0.15. Multiple sets of dry vertical cracks in a VTI host not only result in nearly orthorhombic effective symmetry but also their cumulative influence is equivalent to that of just two orthogonal (or principal) fracture sets. The possibility of replacing multiple fracture sets with two orthogonal ones paves the way for their characterization. The inverse problem of estimating the parameters of two orthogonal crack systems in a VTI background from the effective elasticity, however, is known to be nonunique. I suggest overcoming its ambiguity by combining 3D, wide-azimuth, multicomponent seismic data with sonic logs.
Fourier Transform Spectroscopy, Eleventh International Conference. Proceedings (1998)

These proceedings represent the papers presented at the Eleventh International Conference on Fourier Transform Spectroscopy held in August, 1997 in Athens, Georgia, USA. The Conference provided an atmosphere for people of diverse backgrounds to congregate and exchange information. The topics discussed included applications of Fourier transform spectroscopy to surface science, biological systems, atmospheric science, forensics and textiles, etc. Biochemical and biomedical studies utilizing Fourier Transform infrared spectroscopy formed a large section of the Conference Applications to semiconductor industry, namely monitoring of CVD processes and photoresists were also discussed. Most of the applications were in the near and mid infrared, with a few extending to the far infrared and visible regions of the electromagnetic spectrum. In the Keynote Address, Fourier Transform Ion Cyloctron Resonance Spectroscopy was reviewed by Professor Alan G. Marshall of the National High Magnetic Field Laboratory in Florida. Altogether 152 papers were presented at the Conference and out of these, 15 have been abstracted for the Energy, Science and Technology database. (AIP)
Polyfunctional properties of hybridoma lupus anticoagulant antibodies. (1987)

Lupus anticoagulant antibodies are antiphospholipid antibodies which are characterized by their ability to prolong the clotting time in in vitro coagulation assays measuring the partial thromboplastin time (PTT). In our study, we have analyzed 11 hybridoma lupus anticoagulant antibodies and studied their reactivity with hexagonal and lamellar phospholipids, DNA, IgG, cytoskeletal components, and intact platelets. Our results demonstrate that hexagonal phase phospholipids but not lamellar phospholipids were able to neutralize the lupus anticoagulant activity of all 11 hybridoma antibodies. However, the lupus anticoagulant antibodies differed from one another in their reactivity with DNA, the Fc fragment of IgG, cytoskeletal proteins and platelets. Some of the lupus anticoagulant antibodies reacted with all of these structures, while others reacted with only some or none of the antigens tested. Isoelectric focusing gel analysis confirmed that this polyreactivity was due to a single antibody. Direct binding of lupus anticoagulant antibodies to intact platelets was shown to correlate with the DNA binding activity of the antibodies. Lupus anticoagulant antibodies were also capable of inducing a morphological shape change in platelets. Our data suggest that hybridoma lupus anticoagulant antibodies may react as lupus anticoagulant antibodies only, anti-DNA antibodies, rheumatoid factors, anticytoskeletal antibodies, and antiplatelet antibodies. The degree of overlap in these subgroups and the epitopes responsible for these multiple reactivities remain to be determined.
Generalization bounds and learning rates for Regularized principal manifolds (1998)

We derive uniform convergence bounds and learning rates for regularized principal manifolds. This builds on previous work of Kegl et al., however we are able to obtain stronger bounds taking advantage of the decomposition of the principal manifold in terms of kernel functions. In particular, we are able to give bounds on the covering numbers which are independent of the number of basis functions (line elements) used. Finally we are able to obtain a nearly optimal learning rate of order O(m \\Gamma 1 2 +ff ) for certain types of regularization operators, where m is the sample size and ff an arbitrary positive constant. A companion paper [4] describes the basic algorithm, details of the implementation and experimental results.
The Chemistry of Xylylenes. IV. The Stabilization of Benzyl Radicals in Solution (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of Xylylenes. IV. The Stabilization of Benzyl Radicals in SolutionL. A. ERREDE and J. P. CASSIDYCite this: J. Org. Chem. 1959, 24, 12, 1890–1892Publication Date (Print):December 1, 1959Publication History Published online1 May 2002Published inissue 1 December 1959https://doi.org/10.1021/jo01094a016Request reuse permissions Article Views68Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (401 KB) Get e-Alertsclose Get e-Alerts
ADAM23 (ADAM metallopeptidase domain 23) (2017)

ADAM23 belongs to the ADAM (A Disintegrin And Metalloproteinase domain) family of proteins. Members of this family present a common structural organization including metalloprotease, disintegrin, cystein-rich, epidermal growth factor-like, transmembrane and cytoplasmatic domains and are structurally related to snake venom disintegrins. ADAM23 has close similarity to ADAM11 and ADAM22; is highly expressed in the CNS, and is crucial for normal brain development. Mice homozygous for an insertional mutation that inactivates the gene are smaller than normal littermates, show delayed lung development, are lethal by postnatal day 14, and display severe tremor and ataxia. ADAM23 does not present metalloprotease activity and probably plays its biological role through the disintegrin domain. ADAM23 is involved in cell-cell adhesion and communication and cell-matrix modulation. The ADAM23 gene is frequently silenced by DNA promoter methylation in different types of solid cancers and epigenetic inactivation is associated with cancer progression, increased tumor cell mobility and reduced tumor cell proliferation.
The effect of sacral nerve stimulation on distal colonic motility in patients with faecal incontinence (2013)

SNS modulates colonic motility in patients with faecal urge incontinence. These data suggest that SNS may improve continence and urgency through alteration of colonic motility, particularly by increasing retrograde PSs in the left colon.
The Gallium(III) and Indium(III) Complexes of Tris(2-mercaptobenzyl)amine and Tris(2-hydroxybenzyl)amine (1998)

Tris(2-mercaptobenzyl)amine, S3N, and tris(2-hydroxybenzyl)amine, O3N, were investigated with In3+ and Ga3+ in solution and in the solid state to help interpret the contrasting in vivo behavior of their complexes as diagnostic imaging probes. To this end the protonation and metal binding constants were determined and their similarities and differences with those of analogous ligands, including the O3N analogue, are discussed. Seven new crystal structures of Ga(III) and In(III) complexes are also reported: [Ga(S3N)], [Ga(S3N)(1-Me-imid)], [In(S3N)(1-Me-imid)], [In(S3N)(DMF)], [Ga(O3N)(1-Me-imid)], [Ga(O3N)(DMF)], and [In(O3N‘)(1-Me-imid)2], where O3N‘ is the tris(2-hydroxy-3,5-dimethylbenzyl)amine homologue of O3N. The structure of [Ga(S3N)] is 4-coordinate, that of [In(O3N‘)(1-Me-imid)2] is 6-coordinate, and the remaining structures are 5-coordinate.