gebhart/patrepeval huggingface dataset:
Critical roles of glycosylphosphatidylinositol for <i>Trypanosoma brucei</i> (2000)

Trypanosoma brucei, the protozoan parasite responsible for sleeping sickness, evades the immune response of mammalian hosts and digestion in the gut of the insect vector by means of its coat proteins tethered to the cell surface via glycosylphosphatidylinositol (GPI) anchors. To evaluate the importance of GPI for parasite survival, we cloned and disrupted a trypanosomal gene, TbGPI10, involved in biosynthesis of GPI. TbGPI10 encodes a protein of 558 amino acids having 25% and 23% sequence identity to human PIG-B and Saccharomyces cerevisiae Gpi10p, respectively. TbGPI10 restored biosynthesis of GPI in a mouse mutant cell line defective in mouse Pig-b gene. TbGPI10 also rescued the inviability of GPI10-disrupted S. cerevisiae, indicating that TbGPI10 is the orthologue of PIG-B/GPI10 that is involved in the transfer of the third mannose to GPI. The bloodstream form of T. brucei could not lose TbGPI10; therefore, GPI synthesis is essential for growth of mammalian stage parasites. Procyclic form cells (insect stage parasites) lacking the surface coat proteins because of disruption of TbGPI10 are viable and grow slower than normal, provided that they are cultured in nonadherent flasks. In regular flasks, they adhered to the plastic surface and died. Infectivity to tsetse flies is partially impaired, particularly in the early stage. Therefore, parasitespecific inhibition of GPI biosynthesis should be an effective chemotherapy target against African trypanosomiasis.
Atmospheric corrosion of stainless steels used for the eaves of buildings (1996)

The atmospheric corrosion behavior of different stainless steels (SS) applied to the eaves of a building in a coastal area was investigated. SS used for the eaves corroded more severely than those for the roof. The influence of the angle of the eaves on the atmospheric corrosion of SS was studied with an exposure test stand simulating eaves. The steeper the angle, the more SS corroded due to the accumulation of chloride on the test specimens. High-grade SS (% Cr + 3x% Mo > 28 mass%) are required for eaves use.
Distinct Guanine Nucleotide Binding Protein Alpha-Subunit Receptor Coupling in GH Cell Lines: <i>Effects of Bromocriptine and Hormones on Effector Enzyme Modulation</i> (2001)

The purpose of the present study was to elucidate how the dopamine agonist bromocriptine affected receptor-effector systems in GH cells by measuring adenylate cyclase (AC) and phospholipase C (PL-C) modulation in cell membrane preparations. To perturb the interaction between the receptor and G-protein, polyclonal antibodies reacting with the predicted C-terminal amino acid sequence of G-protein alpha-subunits were used. The effect of bromocriptine on secretagogue elicited prolactin (PRL) secretion from whole cells was also monitored. Bromocriptine inhibited the basal secretion of PRL in a dose dependent manner, and completely abolished both the thyroliberin (TRH) and the vasoactive intestinal peptide (VIP) stimulated PRL secretion in GH(3) cells. Maximal inhibitory effect on PRL egress elicited by both hormones was obtained at 10-50 microM of bromocriptine. Messenger RNAs for both the short and long form of the D(2) receptor (D(2)R) were demonstrated in all three GH cell lines using the RT-PCR technique, advocating that D(2)Rs are coupled to distinct G-proteins and, thus, probably being responsible for the observed effects of bromocriptine in these cell lines. Basal AC activity, as measured in membrane preparations of GH(3) cells, remained unaffected by bromocriptine treatment (10 microM), while TRH and VIP stimulated AC activities (175% and 350% of control values, respectively) were partially inhibited (by some 50%). This inhibitory effect of bromocriptine was completely and specifically abolished in the presence of an antiserum against G(i2)alpha. Basal PL-C activity was also unaffected by bromocriptine, while TRH stimulated PL-C activity (350% of control value) was inhibited by bromocriptine (10 microM) by approximately 50%. Immunoblocking of G(q/11)alpha, however, reduced the stimulatory effect of TRH on PL-C activation by some 65%, while an antiserum against G(o)alpha partly counteracted the inhibitory effect of bromocriptine (10 microM) on TRH stimulated PL-C activity. Thus, TRH dependent AC stimulation was counteracted by bromocriptine via G(i2). TRH activation of PL-C occurs via G(q/11), while inhibition by bromocriptine appears to involve G(o). These mechanisms probably account for the major part of the actions of bromocriptine, however, other not yet recognised intermediates may be involved.
Edgel templates for fast planar object detection and pose estimation (2011)

We describe a method to select edgels and to calculate gradient orientation-based template descriptors for edgel features. An edgel is selected within a grid block based on gradient magnitude; its position and orientation are used to determine a canonical frame where the descriptor is computed based on quantized orientation. The resulting descriptor is efficiently matched using logical operations. We demonstrate the use of the resulting edgel detection and description method for planar object detection and pose estimation.
Commutant lifting for linear time-varying systems (2009)

In this paper, we study two robust control problems for possibly infinite dimensional (i.e., systems with an infinite number of states) linear time-varying (LTV) systems using a framework based on a version of the commutant lifting theorem developed for nest algebras. The approach is purely operator theoretic and does not use any state space representation. The two problems studied include the optimal disturbance attenuation and the optimal mixed sensitivity problems for LTV systems. The proposed solutions are given in terms of projections of time-varying multiplication operators. The latter are computed explicitly.
Base or General Hospitals During the Civil War (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Local Immunotherapy of Seasonal Allergic Rhinitis in Children Due to <i>Parietaria officinalis</i> Pollen: A Preliminary Report (1993)

Fifteen children presenting with a typical allergic rhinitis due to the pollens of Parietaria officinalis were investigated. Diagnosis was confirmed by history, physical examination, skin tests, radioallergosorbent test, and the nasal provocation test. Patients were separated into two groups: Ten received specific nasal immunotherapy and five were on placebo. Results were assessed on the following criteria: diminution of clinical symptomatology, reduction of the quantity of medication required to control symptoms, and results of provocation nasal tests, that showed an increase of the end point, which is the maximum tolerated dose. Compared to a placebo group, the ten children showed a significant improvement in all the cases without any side effects.
Synthesis, Anticancer, Antitubercular and Antimicrobial Activity of 6‐Carbethoxy‐5‐(3′‐chlorophenyl)‐3‐aryl‐2‐cyclohexenones and 6‐Aryl‐4‐(3′‐chlorophenyl)‐3‐oxo‐2,3a,4,5‐tetrahydro‐1H‐indazoles. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Left Ventricular Hypertrophy in Rabbits Does Not Exaggerate the Effects of Halothane on the Intracellular Components of Cardiac Contraction (1992)

Inhalational anesthetics and ventricular hypertrophy have adverse effects on cardiac muscle contraction. The effects of 1, 2, and 3% halothane on the contractile protein and sarcoplasmic reticulum, but not the sarcolemma, were examined in normal left ventricular tissue from rabbits that underwent a sham surgical procedure (n = 5) and in left ventricular hypertrophied tissue from surgically induced aortic coarctation (n = 7). Muscle samples were mechanically "skinned" to disrupt the sarcolemma. Fiber bundles were mounted in photodiode transducers and bathed in a series of solutions designed to examine the contractile protein [Ca2+]-tension responses or to examine Ca2+ storage by and release from the sarcoplasmic reticulum. Hill equation analysis of the [Ca2+]-tension relationship of the contractile protein was performed. Compared to normal muscle, hypertrophied muscle was associated with an 8.2% decrease in the [Ca2+] necessary for 50% maximum tension (more sensitive to Ca2+) (P less than 0.001) and an increase in the slope constant of 23% (P less than 0.001). In normal and hypertrophied tissue, each 1% of halothane incrementally decreased the contractile protein response to maximal [Ca2+] by 5% (P less than 0.01), increased the [Ca2+] at 50% maximum tension by 5% (P less than 0.01), and had no effect on the slope of the Hill equation. Halothane also inhibited Ca2+ storage by the sarcoplasmic reticulum. In normal muscle, 1, 2, and 3% halothane decreased the stored Ca2+ to 42, 22, and 9%, respectively, of Ca2+ storage without halothane (P less than 0.001). However, hypertrophied muscle demonstrated slightly less depression (P less than 0.05 by analysis of variance).(ABSTRACT TRUNCATED AT 250 WORDS)
Convective Plumes in a Convective Field (1970)

Abstract The theory of isolated turbulent plumes given earlier is used to study a field of plumes. Each plume is immersed in the turbulent downdraft which comprises the return flow. The field of flow is specified by three parameters: the heat flux into the atmosphere at the surface, the depth of the convecting layer, and the intensity of turbulence at the surface (where turbulence is steadily generated by the wind) and where a plume element which leaves the surface returns there in a downdraft after a period of the order of 103 sec. The change in air properties during this period is of the essence of the problem. Since the process is driven by the changing density resulting from heating, the equations describing the field must be time-dependent in this essential respect. Wind is neglected, and the horizontal pressure gradient assumed to he the same at all heights. The derived plume properties-size, temperature excess, upward velocity and turbulent intensity-are in agreement with observation. The formulati...
Capnography During Jet Ventilation for Laryngoscopy (1997)

Jet ventilation is often used during laryngoscopy to permit improved visualization of the larynx and to eliminate a potentially flammable endotracheal tube when laser surgery of the airway is performed. Observation of chest wall movement and blood gas analysis are the usual standards for assessing the adequacy of ventilation during jet ventilation. It is reasonable to hypothesize that measurement of end-tidal CO2 concentrations during jet ventilation can be used to assess the adequacy of ventilation during jet ventilation. To test this hypothesis, end-tidal CO2 concentrations were determined during mechanical ventilation through an endotracheal tube and during jet ventilation. At the time that each end-tidal measurement was obtained, a sample of arterial blood was also obtained for later blood gas analysis. For both mechanical ventilation and jet ventilation, well defined relationships between end-tidal CO2 and arterial CO2 tensions were obtained. However, the relationships are distinct: the difference in arterial to end-tidal CO2 tension during supraglottic jet ventilation at a conventional respiratory rate was found to be 13.4 +/- 6.8 mm Hg (mean +/- SD) compared with 5.7 +/- 5.2 mm Hg obtained during conventional ventilation through an endotracheal tube.
Behavior of Three Floors for Different Types of Impact (1965)

Impact-noise tests were conducted in the laboratory on three floor constructions: (a) 4-in. concrete slab; (b) and (c) two floated-wood-floor constructions on the same slab (all floors surfaced with the same plastic floor covering). Data were taken using the standard tapping machine and real footfall. Whereas the floated-floor constructions had impact-noise rating (INR) (FHA Bull. 750) 13 and 15 dB greater than the surfaced slab, they did not show a substantial improvement for footfall. Moreover, the floated floor with the higher INR was poorer under footfall.
Regulation of Bcl-2 expression and apoptosis in acute myeloblastic leukaemia cells by granulocyte-macrophage colony-stimulating factor. (1994)

Previous studies have shown that the bcl-2 gene encodes a mitochondrial protein which can inhibit the onset of apoptosis induced by withdrawal of trophic factors or by antitumour drugs. In some malignant cells bcl-2 expression has been demonstrated to be regulated by specific trophic factors which act to suppress apoptosis. Here we have investigated the effect of exogenous and autocrine granulocyte-macrophage colony-stimulating factor (GM-CSF) on both bcl-2 expression and apoptosis in acute myeloid leukaemia (AML) cells. Blasts from 31 patients with AML were studied, this included 21 patients whose cells exhibited variable degrees of autonomous growth in culture and ten patients with non-autonomous growth. Blasts with autonomous growth expressed significantly higher levels of bcl-2 protein, the intensity of fluorescence expressed as soluble fluorochrome per cell was 40.9 +/- 3.6 x 10(3) (mean +/- SD); this compared with an intensity of bcl-2 expression of 19.3 +/- 2.4 x 10(3) for blasts with non-autocrine growth (p < 0.0001 by Mann-Whitney analysis). Blasts with non-autocrine growth rapidly lost viability following 48 h of culture due to the onset of apoptosis. In these cells apoptosis was suppressed by the addition of GM-CSF and bcl-2 protein expression was found to be significantly upregulated. In contrast blasts from patients with autonomous growth and autocrine GM-CSF production failed to show any features of apoptosis in culture. In these cells bcl-2 expression was significantly downregulated following neutralization of autocrine GM-CSF by antibodies. We conclude that bcl-2 expression in AML cells is regulated by GM-CSF, and suggest that the previously demonstrated negative prognostic effect of autocrine growth as a determinant of treatment outcome in AML is in part due to the effect of autocrine GM-CSF in upregulating bcl-2 expression.
Synergy between an antibody and CD8<sup>+</sup> cells in eliminating an established tumor (1997)

We investigated the effector mechanisms operating during the rejection of a transplantable solid lymphoma E.G7 (H-2b) which expresses the gene encoding chicken ovalbumin (OVA). Anti-OVA cytotoxic T lymphocytes (CTL) completely and specifically protected animals from the onset of, but could not eradicate established, E.G7 tumors. The growth of the same lymphoma was also effectively prevented by the antibody GK1.5, whose target molecule, CD4, was expressed on E.G7 cells in vivo. Furthermore, GK1.5 was able to eradicate established solid E.G7 tumors. GK1.5-mediated tumor elimination was due to its antitumor activity, and not to the elimination of regulatory CD4+ cells, based on unimpaired tumor growth in the absence of GK1.5 in animals that genetically lack CD4 T cells. In vitro, GK1.5 did not kill tumor cells: complement activation or apoptosis induction were not evident. In vivo, GK1.5-mediated tumor regression did not depend on natural killer cells, but it absolutely required CD8+ cells and intact Fcgamma receptor. We conclude that, in the E.G7 model, the collaboration of antibody and CTL immunity was crucial for the successful immunotherapy of established tumors. The mechanism of this collaboration is discussed.
A scheme for integrated controller-datapath fault testing (1997)

In systems consisting of interacting datapaths and controllersand utilizing built-in self test (BIST), the datapaths andcontrollers are traditionally tested separately by isolatingeach component from the environment of the system duringtest.This work facilitates the testing of datapath-controllerpairs in an integrated fashion.The key to the approach isthe addition of logic to the system that interacts with theexisting controller to push the effects of controller faults intothe data flow, so that they can be observed at the datapathregisters rather than directly at the controller outputs.Theresult is to reduce the BIST overhead over what is neededif the datapath and controller are tested independently, andto allow a more complete test of the interface between datapathand controller.Fault coverage and overhead resultsare given for four example circuits.
Primary Metabolism in Citrus Fruit as Affected by Its Unique Structure (2019)

Citrus is one of the world's most important fruit crops, contributing essential nutrients, such as vitamin C and minerals, to the human diet. It is characterized by two important traits: first, its major edible part is composed of juice sacs, a unique structure among fruit, and second, relatively high levels of citric acid are accumulated in the vacuole of the juice sac cell. Although the major routes of primary metabolism are generally the same in citrus fruit and other plant systems, the fruit's unique structural features challenge our understanding of carbon flow into the fruit and its movement through all of its parts. In fact, acid metabolism and accumulation have only been summarized in a few reviews. Here we present a comprehensive view of sugar, acid and amino acid metabolism and their connections within the fruit, all in relation to the fruit's unique structure.
ChemInform Abstract: Polyaza Macrocycles Containing the Piperazine Ring as a Semi‐Flexible Moiety (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A rate-based end-to-end multicast congestion control protocol (2002)

Current reliable multicast protocols do not have scalable congestion control mechanisms and this deficiency leads to concerns that multicast deployment may endanger stability of the network. We present a sender-based approach for multicast congestion control targeted towards reliable bulk data transfer. We assume that there are a few bottleneck links in a large scale multicast group at any time period and these bottlenecks persist long enough to be identified and adapted to. Our work focuses on dynamically identifying the worst congested path in the multicast tree and obtaining TCP-friendly throughput on this selected path. We use the network simulator (NS2) to validate and evaluate our congestion control algorithm with both drop-tail and RED gateways.
From Dots to Shapes: an auditory haptic game platform for teaching geometry to blind pupils (2000)

This paper describes "From Dots to Shapes" (FDTS), an auditory platform composed by three classic games ( Simon , Point Connecting and concentration game ) for blind and visually impaired pupils. Each game was adapted to work on a concept of the Euclidean geometry (e.g. ) The tool, , is based on sonic and haptic interaction, and therefore could be used by special educators as a help for teaching basic planar geometry.
Prenatal Ultrasound Detection of Isolated Neural Tube Defects: Is Cytogenetic Evaluation Warranted? (1995)

The prevalence of karyotypic abnormalities is significantly increased in fetuses with isolated neural tube defects; therefore, prompt antenatal genetic evaluation should be considered in such cases.
The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs (1997)

Histone mRNAs are naturally intronless and accumulate efficiently in the cytoplasm. To learn whether there are cis-acting sequences within histone genes that allow efficient cytoplasmic accumulation of RNAs, we made recombinant constructs in which sequences from the mouse H2a gene were cloned into a human beta-globin cDNA. By using transient transfection and RNase protection analysis, we demonstrate here that a 100-bp sequence within the H2a coding region permits efficient cytoplasmic accumulation of the globin cDNA transcripts. We also show that this sequence appears to suppress splicing and can functionally replace Rev and the Rev-responsive element in the cytoplasmic accumulation of unspliced HIV-1-related mRNAs. Like the Rev-responsive element, this sequence acts in an orientation-dependent manner. We thus propose that the sequence identified here may be a member of the cis-acting elements that facilitate the cytoplasmic accumulation of naturally intronless gene transcripts.
Anxiety proneness linked to epistatic loci in genome scan of human personality traits (1998)

A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the Tridimensional Personality Questionnaire. We detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. There was significant evidence of epistasis between the locus on 8p and others on chromosomes 18p, 20p, and 21q. These oligogenic interactions explained most of the variance in Harm Avoidance. There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies.
Dense multiple antenna systems (2002)

We consider multiple antenna systems in which a large number of antennas occupy a given physical volume. In this regime the assumptions of the standard models of multiple antennas systems become questionable. We show that for such spatially dense multiple antenna systems one should expect the behavior of the capacity to be qualitatively different than what the standard multiple antenna models predict.