gebhart/patrepeval huggingface dataset:
Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins (2004)

Melatonin has been shown to bind to the MT1 G protein-coupled receptor (GPCR) in MCF-7 breast cancer cells to modulate the estrogen response pathway suppressing estrogen-induced estrogen receptor alpha (ERalpha) transcriptional activity, blunting ER/DNA binding activity and suppressing cell proliferation. In these studies we have examined the effect of melatonin on the transcriptional activity of the ERalpha and other members of the steroid/thyroid hormone receptor superfamily, namely, the glucocorticoid receptor (GR) and the retinoic acid receptor alpha (RARalpha). As with the ERalpha, melatonin represses ligand (dexamethasone)-induced activation of the GR. This effect of melatonin on ERalpha and GR is blocked by pertussis toxin (PTX) suggesting that melatonin's actions may be mediated via a PTX-sensitive G(alphai) protein. In contrast, melatonin potentiates the action of all-trans-retinoic acid on RARalpha transcriptional activation and enhances RARalpha/DNA binding activity, an action which is not PTX-sensitive. Expression of a dominant-positive G(alphai2) protein, with which the MT1 receptor has been shown to couple, is able to mimic the effect of melatonin on ERalpha but not RARalpha transcriptional activation in breast cancer cells. This demonstrates that GPCRs can modulate the transcriptional activity of various steroid receptors in response to their ligand through activation of different G protein signaling pathways.
HIV Viral Dynamics of Lopinavir/Ritonavir Monotherapy as Second-Line Treatment: A Prospective, Single-Arm Trial (2019)

In this study, the rate of virologic failure among patients on a second-line lopinavir monotherapy regimen was relatively high and predicted by early detectable viremia. However, no LPV/r-associated resistance mutations were detected despite fluctuating low-level viremia, demonstrating the high genetic barrier to resistance of the protease inhibitor class which could be useful in RLS.
Measurements of polyatomic molecule formation on an icy grain analog using fast atoms (2006)

Measurements are reported for production of $\mathrm{C}{\mathrm{O}}_{2}$ resulting from the impact of a monoenergetic $\mathrm{O}(^{3}\mathrm{P})$ beam upon a surface cooled to $4.8\phantom{\rule{0.3em}{0ex}}\mathrm{K}$ and covered with a CO ice. Using temperature-programmed desorption and mass spectrometer detection, one clearly detects increasing amounts of $\mathrm{C}{\mathrm{O}}_{2}$ formation with $\mathrm{O}(^{3}\mathrm{P})$ energies of 2, 5, 10, and $14\phantom{\rule{0.3em}{0ex}}\mathrm{eV}$. This is a measurement of polyatomic molecule formation on a surface in a new regime using superthermal atoms. The chosen surface coverage, surface temperature, and superthermal atom energy simulate conditions in shock-heated circumstellar and interstellar regions.
Economic Development and Innu Settlement: The Establishment of Sheshatshit. (1988)

RESUME This paper documents the circumstances surrounding the comparatively recent settlement of the nomadic Innut of Labrador in a central community. State and health officials and agents of the church at the time initiated programs that focused on economic rehabilitation, formal education and health concerns which they felt would assist in integrating Innut into Canadian industrial society. Ultimately Innut had little choice but to comply with the wishes of these officials and settle when confronted with the difficulties of pursuing traditional practices. Cet article etudie les circonstances qui entourent l'etablissement comparativement recent des Innu nomades du Labrador dans une communaute centrale. Lors de l'etablissement les representants de l'Etat et de la sante et les representants de l'Englise avaient commence des programmes ayant pour but la rehabilitation economique, l'education scolaire et les problemes de sante qu'ils avaient juges susceptibles d'aider a integrer les Innu dans la societe canadienne industrielle. Enfin les Innu n'avaient d'autre choix qu'a se conformer aux desirs de ces representants et se mettre d'accord avec eux lorsqu'on les avait fait voir les difficultes que presentait la continuation des pratiques traditionnelles.
Kinematic and electromyography analysis of paraplegic gait with the assistance of mechanical orthosis and walker (2019)

<b>Objective:</b> To investigate the kinematics, functional sub-tasks, and excitation levels of the trunk and upper extremity muscles of paraplegic subjects during walker-assisted locomotion. <b>Design:</b> Retrospective cross-sectional study. <b>Setting:</b> Gait analysis laboratory. <b>Participants:</b> Eight individuals with spinal cord injury at T12, lower extremity motor score less than 4, and capable of walking independently with the assistance of ankle-foot orthosis and walker. <b>Main Outcome Measures:</b> Kinematics of pelvis, trunk, shoulder and elbow; trajectory of center of mass; and electromyography (EMG) activity of trunk and upper extremity muscles during gait. <b>Results:</b> Four subtasks were characterized for each locomotion step, based on the kinetics and kinematics data: (1) balance adjustment, (2) walker propulsion, (3) leg raising, and (4) leg swing. The latter two involved large lateral maneuvres by the trunk and pelvis and appeared to be the most skill- and muscle activity-demanding subtasks. The main muscles contributing into these subtasks were the ipsilateral paraspinal and abdominal muscles, as well as the contralateral scapulothoracic and shoulder girdle muscles, with EMG intensities significantly higher than their minimum mean intensities (P < 0.05) and those of the contralateral side (P < 0.05). <b>Conclusions:</b> Our results provide more insight into the functional sub-tasks and muscular demands of walker-assisted paraplegic gait that can help to design appropriate muscle strengthening programs, as well as developing more effective gait orthoses.
Increment in Reminiscing After ECT (1999)

Department of Psychiatry Hadassah-Hebrew University Medical Center Jerusalem, Israel Depression Unit Herzog Hospital Jerusalem, Israel
2D simulation of magnetic field generation by pulsating AC voltage in cold plasma chamber (2016)

The importance of numerical modelling and simulation by means of finite element analysis (FEA) has witnessed an increase as computational capability and software development have been substantially improved. These techniques can provide unique insight and aid detailed analysis of phenomena such as plasma arcs. In this digest, a two dimensional cold plasma chamber model has been simulated in a Multiphysics FEA model considering thermal, electrical and magnetics properties on the generation of magnetic field around the arc discharge region.
A Genetic Map of <i>Gibberella zeae</i> (<i>Fusarium graminearum</i>) (2002)

We constructed a genetic linkage map of Gibberella zeae (Fusarium graminearum) by crossing complementary nitrate-nonutilizing (nit) mutants of G. zeae strains R-5470 (from Japan) and Z-3639 (from Kansas). We selected 99 nitrate-utilizing (recombinant) progeny and analyzed them for amplified fragment length polymorphisms (AFLPs). We used 34 pairs of two-base selective AFLP primers and identified 1048 polymorphic markers that mapped to 468 unique loci on nine linkage groups. The total map length is approximately 1300 cM with an average interval of 2.8 map units between loci. Three of the nine linkage groups contain regions in which there are high levels of segregation distortion. Selection for the nitrate-utilizing recombinant progeny can explain two of the three skewed regions. Two linkage groups have recombination patterns that are consistent with the presence of intercalary inversions. Loci governing trichothecene toxin amount and type (deoxynivalenol or nivalenol) map on linkage groups IV and I, respectively. The locus governing the type of trichothecene produced (nivalenol or deoxynivalenol) cosegregated with the TRI5 gene (which encodes trichodiene synthase) and probably maps in the trichothecene gene cluster. This linkage map will be useful in population genetic studies, in map-based cloning, for QTL (quantitative trait loci) analysis, for ordering genomic libraries, and for genomic comparisons of related species.
Gas-lift Optimization by Controlling Marginal Gas-Oil Ratio using Transient Measurements ⁎ ⁎The authors gratefully acknowledge the financial support from SFI SUBPRO, which is financed by the Research Council of Norway major industry partners and NTNU. (2018)

This paper presents the application of a steady-state gradient control using transient measurements to a gas-lift optimization problem. Optimal operation of a gas-lifted field involves controlling the marginal gas-oil ratio (mGOR), which is the steady-state gradient of the oil rate with respect to the gas lift rate. In this paper, we apply a novel method to estimate the marginal GOR online using a dynamic model and transient measurements, without the need for additional perturbation. The proposed method is based on linearizing the dynamic model around the current operating point to estimate the marginal GOR, which is then controlled using simple feedback controllers to achieve optimal operation. In case of disturbances, the proposed method is able to adjust fast to the new optimal point, without the need to solve computationally expensive optimization problems. By using transient measurements, it does not need to wait for the process to reach steady-state to update the model. The proposed method was tested in simulations and was shown to provide similar performance as an economic MPC.
A Free Radical Mannich Type Reaction: Selective α‐CH Aminomethylation of Ethers by Ti(III)/t‐BuOOH System under Aqueous Acidic Conditions. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Effektelektronik - teknologi med energibesparelser og forbedret performance (2004)

Lige siden transistoren blev opfundet, har det altid været ønskeligt at kunne anvende en sådan til at styre store strømme/spændinger i elektriske systemer. Det er teknologisk også sket, først med tyristorer til styring af store effekter, men siden hen også med den bipolare transistor MOSFET, samt helt nye transistorer med bedre egenskaber. Udviklingen har været drevet af, på et givet areal af silicium, at kunne pakke så mange transistorer i parallel som muligt for derved at kunne reducere tabene. Teknologiudviklingen har primært været drevet af udviklingen af hukommelseskredse, hvorefter effekt-transistorerne har kunnet udvikles/produceres på disse produktionslinjer.
The use and safety of transoesophageal echocardiography in the general ICU – a minireview (2004)

TEE is safe, well-tolerated and useful in the management of critically ill patients. This applies as well for hemodynamically unstable patients in a general surgical ICU.
STRAIN-SENSING CARBON NANOTUBE CEMENT-BASED COMPOSITES FOR APPLICATIONS IN STRUCTURAL HEALTH MONITORING: PREPARATION AND MODELLING ISSUES (2015)

STRAIN-SENSING CARBON NANOTUBE CEMENT-BASED COMPOSITES FOR APPLICATIONS IN STRUCTURAL HEALTH MONITORING: PREPARATION AND MODELLING ISSUES - 1st International Conference on Uncertainty Quantification in Computational Sciences and Engineering - 25 - 27 May 2015 Crete Island, Greece
mGluR5 antagonism increases autophagy and prevents disease progression in the <i>zQ175</i> mouse model of Huntington’s disease (2017)

Huntington's disease (HD) is a neurodegenerative disease caused by an expansion in the huntingtin protein (also called Htt) that induces neuronal cell death with age. We found that the treatment of 12-month-old symptomatic heterozygous and homozygous <i>zQ175</i> huntingtin knockin mice for 12 weeks with CTEP, a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), reduced the size and number of huntingtin aggregates, attenuated caspase-3 activity, and reduced both neuronal apoptosis and neuronal loss in brain tissue. Both motor and cognitive impairments were improved in CTEP-treated <i>zQ175</i> mice. The reduction in huntingtin protein aggregate burden by CTEP correlated with the activation of an autophagy pathway mediated by the kinase GSK3β, the transcription factor ZBTB16, and the autophagy factor ATG14. Inhibition of mGluR5 with CTEP also reduced the inhibitory phosphorylation of the autophagosome biogenesis-related kinase ULK1, increased the phosphorylation of the autophagy factor ATG13, and increased the abundance of the autophagy-related protein Beclin1 in homozygous <i>zQ175</i> mice. The findings suggest that mGluR5 antagonism may activate autophagy through convergent mechanisms to promote the clearance of mutant huntingtin aggregates and might be therapeutic in HD patients.
Snoring in primary school children and domestic environment: A Perth school based study (2004)

Snoring is common in primary school children. Domestic environments may play a significant role in the increased prevalence of snoring. Exposure to nitrogen dioxide in domestic environment is associated with snoring in children.
Vinblastine Determination Measured by a Sensitive ELISA Inhibition Assay (1996)

Specific monoclonal antibodies(mAbs) against bis-indole alkaloids related to vinblastine were established to develop a simple and specific immunoassay system for the quantitation of Vinca alkaloids. Vinca alkaloids were extracted from tissue cultured cells of periwinkle plant (Vinca rosea L.). Spleen cells from Balb/c mice immunized with vinblastine-bovine serum albumin(VBL-BSA) conjugate as immunogen were fused with myeloma cells(Sp2/0-Ag.14) in the presence of polyethylene glycol. In the preliminary experiments, 32 clones which highly reacted with VBL-BSA conjugate were selected by ELISA(Enzyme-linked immunosorbent assay). These clones were further analyzed by inhibition assay of ELISA. The results obtained with two typical monoclonal antibodies, KN-1 and KN-2, were described. KN-1 exhibited considerable reactivities with soluble dimeric bis-indole alkaloids, whereas no cross reacted with monomeric bis-indole alkaloids. However KN-2 showed cross reactivity with mono- and di-meric bis-indole alkaloids. Furthermore, KN-1 was applied to the immunoassay system for determining the VBL amounts of in vitro cultured cell extracts. This assay system could detect dimeric vinca alkaloid as low as 0.05 nM.
Structure of Escherichia coli UMP Kinase Differs from That ofOther Nucleoside Monophosphate Kinases and Sheds New Light on EnzymeRegulation (2005)

Bacterial UMP kinases are essential enzymes involved in the multistep synthesis of nucleoside triphosphates. They are hexamers regulated by the allosteric activator GTP and inhibited by UTP. We solved the crystal structure of Escherichia coli UMP kinase bound to the UMP substrate (2.3 A resolution), the UDP product (2.6 A), or UTP (2.45 A). The monomer fold, unrelated to that of other nucleoside monophosphate kinases, belongs to the carbamate kinase-like superfamily. However, the phosphate acceptor binding cleft and subunit assembly are characteristic of UMP kinase. Interactions with UMP explain the high specificity for this natural substrate. UTP, previously described as an allosteric inhibitor, was unexpectedly found in the phosphate acceptor site, suggesting that it acts as a competitive inhibitor. Site-directed mutagenesis of residues Thr-138 and Asn-140, involved in both uracil recognition and active site interaction within the hexamer, decreased the activation by GTP and inhibition by UTP. These experiments suggest a cross-talk mechanism between enzyme subunits involved in cooperative binding at the phosphate acceptor site and in allosteric regulation by GTP. As bacterial UMP kinases have no counterpart in eukaryotes, the information provided here could help the design of new antibiotics.
Spatio-Temporal Evolution of Sporulation in Bacillus thuringiensis Biofilm (2016)

Bacillus thuringiensis can produce a floating biofilm which includes two parts: a ring and a pellicle. The ring is a thick structure which sticks to the culture container, while the pellicle extends over the whole liquid surface and joins the ring. We have followed over time, from 16 to 96 h, sporulation in the two biofilm parts. Sporulation was followed in situ in 48-wells polystyrene microtiterplates with a fluorescence binocular stereomicroscope and a spoIID-yfp transcriptional fusion. Sporulation took place much earlier in the ring than in the pellicle. In 20 h-aged biofilms, spoIID was expressed only in the ring, which could be seen as a green fluorescent circle surrounding the non-fluorescent pellicle. However, after 48 h of culture, the pellicle started to express spoIID in specific area corresponding to protrusions, and after 96 h both the ring and the whole pellicle expressed spoIID. Spore counts and microscopy observations of the ring and the pellicle harvested separately confirmed these results and revealed that sporulation occured 24 h-later in the pellicle comparatively to the ring, although both structures contained nearly 100% spores after 96 h of culture. We hypothesize that two mechanisms, due to microenvironments in the biofilm, can explain this difference. First, the ring experiences a decreased concentration of nutrients earlier than the pellicle, because of a lower exchange area with the culture medium. An second, the ring is exposed to partial dryness. Both reasons could speed up sporulation in this biofilm structure. Our results also suggest that spores in the biofilm display a phenotypic heterogeneity. These observations might be of particular significance for the food industry, since the biofilm part sticking to container walls - the ring - is likely to contain spores and will therefore resist both to washing and to cleaning procedures, and will be able to restart a new biofilm when food production has resumed.
Spectroscopic characterization of oral epithelial dysplasia and squamous cell carcinoma using multiphoton autofluorescence micro‐spectroscopy (2017)

Neoplastic transformation in the epithelium is known to alter the intracellular homeostasis of important tissue metabolites such as NADH, FAD, and PpIX, which was observed by MPAS in their native environment. A combination of deep tissue microscopy owing to higher penetration depth of multiphoton excitation and depth resolved spectroscopy could prove to be invaluable in identification of cytologic as well as biomolecular spectral characteristic of oral epithelial neoplasia. Lasers Surg. Med. 49:866-873, 2017. © 2017 Wiley Periodicals, Inc.
Wet carbonization of lump-size low-rank coals by a novel non-slurry approach: Progress report for the period February-April 1986 (1986)

Construction of the process research unit (PRU) was completed with the successful modification and shakedown testing of the high-pressure steam boiler. Following an initial shakedown test of the PRU, four wet carbonization tests were conducted: a test (86-PRU-1) to determine the wet carbonization characteristics of (-1+1/2 inch) North Dakota Indianhead lignite, a replicate test (86PRU-2) to determine reproducibility of data, a test (86PRU-3) to determine the effect of residence time, and a test (86PRU-4) to determine the effect of partial wet oxidation using air feed to the reactor. The PRU and ancillary equipment operated smoothly, and system temperature and pressure controls operated well. The operating conditions for the four tests were a residence time of 0.3 to 1.1 hours and a temperature of about 550F. Air was used in the fourth test as a means of providing a portion of the required process heat. Product solid, liquid, and gas samples were taken for analyses. Two successful tests were conducted in the free-fall devolatilization reactor with raw Texas lignite and Montana subbituminous coals. These tests were conducted at a temperature of 1300F and a pressure of 500 psig with a steam-hydrogen mixture (50 mole percent hydrogen). About 150 grams of coalmore » were fed during the 60-minute duration of the tests. The product solid, liquid, and gas samples from the tests are being analyzed. Anaerobic digestion tests continued with filtered product water from the batch wet carbonization unit and the PRU. The objective of these tests is to determine the preferred reactor configuration and operating conditions for producing methane from and reducing the chemical oxygen demand of the wet carbonization product water.« less
Intensive Methotrexate and Cytarabine Followed by High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Patients With Newly Diagnosed Primary CNS Lymphoma: An Intent-to-Treat Analysis (2003)

This treatment approach is feasible in patients with newly diagnosed PCNSL without evidence of significant related neurotoxicity. Although the transplantation results are similar to those achieved in patients with aggressive or poor-prognosis systemic lymphoma, the low response rate to induction chemotherapy and the significant number of patients who experienced relapse soon after HDT suggest that more aggressive induction chemotherapy may be warranted.
Double sign reversal of the vortex Hall effect in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">YBa</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mi mathvariant="normal">−</mml:mi><mml:mi mathvariant="normal">δ</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>thin films in the strong pinning limit of low magnetic fields (2000)

Measurements of the Hall effect and the resistivity in twinned ${\mathrm{YBa}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}\ensuremath{\delta}}$ thin films in magnetic fields B oriented parallel to the crystallographic c axis and to the twin boundaries reveal a double sign reversal of the Hall coefficient for $B<~1$ T. In high transport current densities, or with B tilted off the twin boundaries by $5\ifmmode^\circ\else\textdegree\fi{},$ the second sign reversal vanishes. The power-law scaling of the Hall conductivity to the longitudinal conductivity in the mixed state is strongly modified in the regime of the second sign reversal. Our observations are interpreted as strong, disorder-type dependent vortex pinning and confirm that the Hall conductivity in high-temperature superconductors is not independent of pinning.
The Effect of Al<sub>2</sub>O<sub>3</sub> or SiO<sub>2</sub> Addition on the Thermal Shock Resistance of Y<sub>2</sub>O<sub>3</sub>-Stabilized ZrO<sub>2</sub> (1986)

Y2O3含有量を4-17wt%と変化させた安定化ZrO2の耐熱衝撃性について検討した. 円板試料を1100℃に急熱後, 室温まで約500℃/minで急冷するサイクルを繰り返して熱衝撃試験を行った.ZrO2-4wt% Y2O3は単斜晶ZrO2の割合が多いため, 単斜晶→←正方晶のマルテンサイト変態に伴う寸法変化が著しく, 耐熱衝撃性が劣る. 一方, 立方晶単相のZrO2-12及び17wt% Y2O3では相変態は見られないが, 破壊靱性値が低いためにやはり耐熱衝撃性は劣る. ZrO2-7wt% Y2O3では, 変態に伴う寸法変化が比較的小さく, また破壊靱性値も比較的高いために良好な耐熱衝撃性を示す.ZrO2-7wt% Y2O3に, 更に0.5-4wt%のAl2O3を添加すると気孔率が低下し, 硬さ及び破壊靱性値が向上して耐熱衝撃性が改善される. また, ZrO2-7wt% Y2O3では, 単斜晶ZrO2粒同士が結合して大きな集合体となっているのに対して, Al2O3添加材では球状の単斜晶ZrO2粒が比較的孤立して存在している. 熱衝撃試験において, クラックは主に単斜晶ZrO2から発生すると考えられ, 単斜晶ZrO2の形態の違いも耐熱衝撃性改善の原因の一つと考えられる. なお, SiO2を添加しても耐熱衝撃性の改善は認められない.