gebhart/patrepeval huggingface dataset:
Macroeconomic Implications and China (2009)

Before the subprime crisis, there was hype among western analysts about China decoupling from the economic growth trend of the developed world. Many investment bank economists were pushing the idea of China becoming an independent economic power that could grow organically and at the same time propel global economic growth. In the early stage of the subprime crisis, many people even thought that China could replace the USA as the world growth driver and save the global economy from imploding under the global credit crisis. These thoughts are naïve. Globalisation and China’s internal growth imbalances clearly indicate that there had been no decoupling of Chinese growth and that China could not save the world at this stage of economic development. The subprime crisis has, meanwhile, offered valuable lessons for China’s economic policies and for understanding long-term risks in the Chinese banking sector.
Crystal structure of mono[3-(2-imidazolylthio)]-altro-β-cyclodextrin: elliptical distortion of the cavity and unique ‘Yin–Yang’ stacking (2003)

The title compound is elliptically distorted due to the unusual 1C4 geometry of the altrose portion. In packing, a unique fourfold helical structure is elaborated with head-to-head dimers as the repeating motif. The imidazolyl moieties mutually reside on each other's cavities thereby resembling the Yin-Yang type balancing of antagonisms.
New Type of Paramagnetic Silver Cluster in Sodalite: Ag<sub>8</sub><sup>7+</sup> (2004)

Silver sodalite crystals with hydroxyl guest anion and silver loading higher than 7.9 per unit cell were investigated. EPR spectra of sodalite, recorded just afer g-irradiation at 77K, shows a 9-line, near isotropic signal with giso=1.987 and hyperfine splitting of 8.3 mT. The signal decays completely above 200K. We assign the multiplet to silver octamer Ag8 n+ cluster and tentatively postulate that the cluster charge is +7.
Pharmacological profile of the FLT3-Tyrosine Kinase Inhibitor AST487 (2005)

5988 The FLT3 receptor tyrosine kinase is overexpressed in 70-90% of AML patients. In addition, up to 35% of AML patients harbor mutations in the JM domain or the kinase domain of FLT3. These mutations result in ligand-independent receptor activation and hence to signal transduction and cell proliferation. Inhibition of the FLT3 mediated signalling pathway is considered to be an attractive therapeutic approach in AML. Several FLT3 tyrosine kinase inhibitors (TKI) are currently undergoing clinical evaluation including PKC412 which showed significant blast response in peripheral blood (Stone RM et al. Blood, 2004; Sep 2; Epub). Unfortunately these early clinical responses are often superseded by blast recurrence due to a yet unknown mechanisms of drug resistance. Therefore we aimed at identifying FLT3 inhibitors from a different structural class which displayed enhanced cytotoxicity against mutated FLT3 expressing leukemic cells. This strategy yielded AST487, which incorporates all features of a pharmacological useful drug candidate. AST487 is a small molecular weight inhibitor of FLT3 kinase. Besides inhibitory activity in the nanomolar range against BaF3 cells dependent on ITD (ED 50 1.8 nM) or D835Y ((ED 50 5.1 nM) mutated FLT3, this compound also inhibits related type III tyrosine kinases at cellular level. For example proliferation of BaF3 cells dependent on Tel-PDGFRβ and PCT3-RET as well as VEGF stimulated HUVEC were inhibited by AST487 in the nanomolar range (ED 50s 27-9 nM). AST487 was particularly potent against FLT3-ITD expressing human leukemic cell lines like MV4-11 and MOLM-13 (ED 50s 10%). Repeated dosing of up to 50 mg/kg were well tolerated in mice and yielded plasma levels exceeding the in vitro determined cellular ED 50 concentration for several hours. The human leukaemia cell line MV4-11 can be transplanted subcutaneously into nude mice and the antiproliferative activity of FLT3 inhibitors determined by convenient tumor measurements. Remarkably, daily oral doses of 20 and 50 mg/kg AST487 resulted in full tumor eradication. Repeated daily oral doses of 5 mg/kg AST487 resulted in sustained inhibition of MV4-11 cell proliferation with an T/C of
Calculations of fine-structure changing collisions of excited Xe (1992)

Calculations of cross sections for mixing of Xe(5p{sup 5}nl)(nl=6s,6p,5d) by thermal collisions with He and Ar are reported. Ab initio structure calculations have been performed using the COLUMBUS codes, which include spin orbit effects and relativistic effects in the heavy atom core. A model Hamiltonian approach has been developed that allows the necessary nonadiabatic coupling matrix elements to be determined. The dynamics equations are solved using the coupled channel method, and calculated mixing rates are compared with recent experiments. The mixing rates depend strongly on the particular transition and on the collision partner (He or Ar). The calculations provide an explanation for most of the state-to-state rates in terms of the features of the potential curves.
Quality-guided adaptivity for audiovisual content streaming by MPEG DASH (2012)

HTTP streaming has become a cost effective means for multimedia delivery nowadays. In this paper, we study the use of MPEG DASH standard to stream audiovisual content. Our focus is on a systematic approach for selecting the best audio and video alternatives. For that purpose, we extend the current standard syntax with quality related information.
Model Predictive Control with Reinforcement Learning for Drug Delivery in Renal Anemia Management (2006)

Treatment of chronic conditions often creates the challenge of an adequate drug administration. The intra- and inter-individual variability of drug response requires periodic adjustments of the dosing protocols. We describe a method, combining model predictive control for simulation of patient response and reinforcement learning for estimation of dosing strategy, to facilitate the management of anemia due to kidney failure.
tertiary Alcohol Formation Catalysed by a Rhamnulose-1-PhosphateAldolase : Dendroketose-1-Phosphate Synthesis (2020)

International audience
Immunologic markers of Burkitt's lymphoma cells. (1985)

Lymphocyte markers were studied on fresh cells from 30 patients with Burkitt (L3) leukaemia and cell lines derived from endemic and non-endemic Burkitt's lymphoma (BL) patients. We observed day-to-day variations of lymphocyte marker expression by cultured lines and, occasionally, differences between fresh and cultured cells. In L3 leukaemia, a wide range of phenotypes, including pre-B cell and mature monoclonal IgM + IgD positive B-cell phenotypes, was observed. Most often, the cells expressed high-density monoclonal surface IgM without IgD and lacked IgG Fc, complement and Epstein-Barr virus receptors. Blast cells from rare patients featured monoclonal IgG or IgA instead of IgM. Cases with light chains of the lambda type were more frequent than those with kappa chains. Monoclonal immunoglobulins were found in serum or urine from eight of 20 patients studied. These results are compared with data from the literature on endemic and non-endemic BL and discussed with respect to the maturation stage reached by the cells. In the study of both fresh and cultured cells, we demonstrated a correlation between variant chromosomal translocations and light-chain types, the cells from patients with a t(2;8) translocation expressing kappa and those with a t(8;22) expressing lambda chains, with one exception Vimentin expression was absent or weak in most BLs studied (lines or fresh cells) and in cells from patients with Langer-Giedion syndrome, in contrast to most other lymphomas and leukaemias and normal lymphoblastoid cell lines.
Electronic shell structure of indium-sodium (InnNam) bimetallic clusters examined by their ionization potentials and mass distributions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic shell structure of indium-sodium (InnNam) bimetallic clusters examined by their ionization potentials and mass distributionsAtsushi Nakajima, Kuniyoshi Hoshino, Tsuneyoshi Sugioka, Takashi Naganuma, Tetsuya Taguwa, Yoshiyuki Yamada, Katsura Watanabe, and Koji KayaCite this: J. Phys. Chem. 1993, 97, 1, 86–90Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/j100103a016https://doi.org/10.1021/j100103a016research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Leukotriene Receptor Antagonism and the Prevention of Extracellular Matrix Degradation During Atherosclerosis and In-Stent Stenosis (2009)

These results suggest a key role of LT signaling in the extracellular matrix degradation associated with hyperlipidemia and in-stent stenosis. In conclusion, targeting LT receptors may represent a therapeutic strategy in atherosclerosis and interventional cardiology.
Effects of Angiotensin Type 2 Receptor Overexpression in the Rostral Ventrolateral Medulla on Blood Pressure and Urine Excretion in Normal Rats (2007)

Central angiotensin II plays a critical role in the regulation of cardiovascular function and autonomic activity, in part, via angiotensin type 1 receptors in the rostral ventrolateral medulla (RVLM). Increasing evidence indicates that angiotensin II can also act on angiotensin type 2 receptors (AT(2)Rs) to exert antagonistic effects. In the current study we determined the effects of overexpression of AT(2)R in the RVLM on sodium and water excretion and on blood pressure in conscious rats. The overexpression of AT(2)R was induced by bilateral microinjection of the AT(2)R adenovirus (Ad5-SYN-AT2R-IRES-EGFP, 2.5 x 10(6) infection units in 0.5 microL; Ad5-SYN-EGFP as the control, 2.5 x 10(6) infection units in 0.5 microL) into the RVLM of rats. Immunofluorescence staining showed that microinjection of AT(2)R adenovirus into the RVLM evoked local overexpression. Significant overexpression of AT(2)R in the RVLM began at 24 hours and was sustained up to 12 days after microinjection. Overexpression of AT(2)R in the RVLM significantly decreased the nocturnal arterial blood pressure and increased the 24-hour urine excretion at days 2, 3, and 4 after gene delivery compared with the control rats. These alterations were abolished by the microinfusion of captopril into the RVLM and were enhanced by angiotensin II infusion. Overexpression of AT(2)R in the RVLM also significantly decreased the urine concentration of noradrenaline and 24-hour noradrenaline excretion (1.1+/-0.5 microg in control rats and 2.4+/-0.5 microg in AT(2)R rats; P<0.05). These results suggest that overexpression of AT(2)R in the RVLM induced a diuresis that may be mediated, in part, by sympathoinhibition.
Retinoic Acid-Induced Down-Regulation of the Interleukin-2 Promoter via <i>cis</i> -Regulatory Sequences Containing an Octamer Motif (1991)

Retinoic acid (RA) is known to influence the proliferation and differentiation of a wide variety of transformed and developing cells. We found that RA and the specific RA receptor (RAR) ligand Ch55 inhibited the phorbol ester and calcium ionophore-induced expression of the T-cell growth factor interleukin-2 (IL-2) gene. Expression of transiently transfected chloramphenicol acetyltransferase vectors containing the 5'-flanking region of the IL-2 gene was also inhibited by RA. RA-induced down-regulation of the IL-2 enhancer is mediated by RAR, since overexpression of transfected RARs increased RA sensitivity of the IL-2 promoter. Functional analysis of chloramphenicol acetyltransferase vectors containing either internal deletion mutants of the region from -317 to +47 bp of the IL-2 enhancer or multimerized cis-regulatory elements showed that the RA-responsive element in the IL-2 promoter mapped to sequences containing an octamer motif. RAR also inhibited the transcriptional activity of the octamer motif of the immunoglobulin heavy chain enhancer. In spite of the transcriptional inhibition of the IL-2 octamer motif, RA did not decrease the in vitro DNA-binding capability of octamer-1 protein. These results identify a regulatory pathway within the IL-2 promoter which involves the octamer motif and RAR.
ChemInform Abstract: STUDIES OF OXAZOLOBENZODIAZEPINES. PART 7. SYNTHESIS OF 3‐METHYLOXAZOLO(3,2‐D)(1,4)BENZODIAZEPINES AND CONFIGURATIONAL STUDIES OF THEIR KETIMINE INTERMEDIATES (1979)

Abstract Aminolyse der Bromacetamidobenzophenone (I) mit den Aminen (II) liefert die Derivate (III), die mit dem Aminoalkohol (IV) zu den Ketiminen (V) [(Va) 1:1 syn/anti‐Gemisch] umgesetzt werden; die daraus hergestellten quaternären Salze (VI) werden mit DMF/CaCO3 zu den Oxazolobenzodiazepinonen (VII) [(VIIa) cis‐Konfiguration] cyclisiert.
Drug‐resistant pneumococci in children with acute lower respiratory infections in Vietnam (2008)

gPRSP strains with serotype 19F or 23F are highly prevalent among pediatric patients with ALRI under 5 years of age in Hanoi, Vietnam.
Über eine neue, polymorphe Form des Mangandioxyds (1958)

Abstract Es werden Darstellung und Eigenschaften von ϵ‐MnO 2 , einer neuen polymorphen Modifikation des Mangandioxyds, mitgeteilt. Bei eintägigem Erhitzen auf 425° C geht ϵ‐MnO 2 in β‐MnO 2 (Pyrolusit) über; bei 525° C tritt α‐MnO 2 auf.
Residue-driven architecture for computational auditory scene analysis (1995)

The Residue-Driven Architecture presented here is a model of auditory stream segregation from input sounds. A subsystem to extract auditory streams by using some sound attributes is called an agency and the design of each agency is based on the residue-driven architecture. This architecture consists of three kinds of agents: an event-detector, a tracer-generator, and tracers. The event-detector calculates a residue by subtracting the predicted input from the actual input. When a residue exceeds a threshold value, tracer-generator generates a tracerthat extracts an auditory stream from the residue and returns a predicted input of the next time frame to the event-detector. This aproach improves the performance of segregation and the resulting system can segregate a woman's voiced stream, a man's voiced stream, and a noise stream from a mixture of these sounds. Binaural segregation is also designed by the architecture.
Three-Dimensional Nanostructured Networks (2020)

This chapter discusses the latest advances in the design of effcient architectures for the fabrication of highly performing nanoparticle- and nanocluster-based devices. The latter include high sensitivity to surface states, quantum confinement, short electron–hole separation lengths, tunable light scattering, and unique surface reaction sites. A nanoparticle network can be defined as a reproducible 3D assembly of nanoparticles, with most of the particles sharing at least a contact point with another one. The particle deposition mechanism is controlled by the ratio between diffusion and translational velocity of the particle, ranging from diffusion to the ballistic limit regimes. The electrostatic spray deposition relies on the atomization of precursor solutions by the supply of a strong electric field between a nozzle and a grounded substrate. Spark discharge generation is a well-established, solvent-free technique for the generation of sub-10 nm nanoparticles.
Mitochondrial redox state as a potential detector of liver dysoxia in vivo (1998)

Dysoxia can be defined as ATP flux decreasing in proportion to O2 availability with preserved ATP demand. Hepatic venous beta-hydroxybutyrate-to-acetoacetate ratio (beta-OHB/AcAc) estimates liver mitochondrial NADH/NAD and may detect the onset of dysoxia. During partial dysoxia (as opposed to anoxia), however, flow may be adequate in some liver regions, diluting effluent from dysoxic regions, thereby rendering venous beta-OHB/AcAc unreliable. To address this concern, we estimated tissue ATP while gradually reducing liver blood flow of swine to zero in a nuclear magnetic resonance spectrometer. ATP flux decreasing with O2 availability was taken as O2 uptake (VO2) decreasing in proportion to O2 delivery (QO2); and preserved ATP demand was taken as increasing Pi/ATP. VO2, tissue Pi/ATP, and venous beta-OHB/AcAc were plotted against QO2 to identify critical inflection points. Tissue dysoxia required mean QO2 for the group to be critical for both VO2 and for Pi/ATP. Critical QO2 values for VO2 and Pi/ATP of 4.07 +/- 1.07 and 2.39 +/- 1.18 (SE) ml . 100 g-1 . min-1, respectively, were not statistically significantly different but not clearly the same, suggesting the possibility that dysoxia might have commenced after VO2 began decreasing, i.e., that there could have been "O2 conformity." Critical QO2 for venous beta-OHB/AcAc was 2.44 +/- 0.46 ml . 100 g-1 . min-1 (P = NS), nearly the same as that for Pi/ATP, supporting venous beta-OHB/AcAc as a detector of dysoxia. All issues considered, tissue mitochondrial redox state seems to be an appropriate detector of dysoxia in liver.
A role for the hippocampal formation in implicit memory (1998)

The apparent preservation of word priming effects in amnesia has been interpreted as supporting the view that implicit memory depends on brain systems that are independent of mesial temporal lobe structures which are in part responsible for explicit memory disorders. Nevertheless, a number of studies have demonstrated word priming deficits in amnesic patients relatively to normal subjects, suggesting that such structures may also be involved in implicit memory. To determine whether one such structure, the hippocampal formation, is a component of the brain system subserving word priming, a 3-D PET study was carried out in 13 normal individuals. Encoding was carried out using the brief multiple presentation technique, a procedure that allows one to effectively circumvent contamination of implicit memory tasks by explicit memory strategies. Results revealed that word priming was indeed associated with an activation of the right hippocampal formation. This finding of an hippocampal involvement in word priming calls into question the notion of absolute dissociability between the brain systems underlying performance on various explicit and implicit memory tasks.
Low-Dose Felodipine Treatment Attenuates Endothelial Dysfunction in Rabbits Fed an Atherogenic Diet (1991)

Loss of endothelium-dependent relaxation is an early step in atherogenesis. To test the effect of low-dose felodipine on the progression of this dysfunction, male New Zealand white rabbits were rendered hypercholesterolemic with a diet containing 0.25% cholesterol and 3% coconut oil. After a 1-month induction period on this diet, during which the rabbits were identified as low or normal responders to cholesterol, 0.46 mg/kg of felodipine (FELO) or placebo (CON) were given by gavage once daily for a further 3 months. This regimen established FELO plasma levels (14.2 +/- 1.3 nM, week 9) corresponding to therapeutic concentrations in humans and an average 13-fold increase in plasma cholesterol from below 1 mM. At the end of the treatment period, relaxation of norepinephrine (1 x 10(-8) M)-precontracted proximal thoracic aorta strips to acetylcholine (ACh: 1 x 10(-8)-1 x 10(-5) M) was determined. Cholesterol exposure was calculated as the area under the curve for serum cholesterol x time [AUC (mM x day 1)]. Despite equal cholesterol load [FELO (n = 17): 1,856 +/- 182 mM x day) and CON (n = 22): 1,851 +/- 167 mM x day], maximal relaxation to 1 x 10(-7) M ACh was well preserved in strips from FELO-treated rabbits (29.5 +/- 5.7%) but suppressed in strips from untreated rabbits (11.0 +/- 2.9%). For comparison, relaxation in strips from standard diet controls was 49.8 +/- 2.9% (n = 15). Moreover, there was a significant inverse correlation (r = -0.74) between percentage ACh relaxation and cholesterol exposure in FELO-treated rabbits.(ABSTRACT TRUNCATED AT 250 WORDS)
Infection of Tobacco Mesophyll Protoplasts by Alfalfa Mosaic Virus (1975)

SUMMARY The best conditions found for infection of tobacco mesophyll protoplasts with alfalfa mosaic virus (AMV) were pH 5.2, 2.5 μg/ml virus and 1 μg/ml poly-l-ornithine. Newly synthesized virus could be detected 15 h after inoculation and the virus concentration reached an estimated 106 to 107 particles per infected protoplast 2 days after inoculation.
Ocular Surface Fibroma: Clinical, Histopathological, and Immunohistochemical Features of 10 Cases (2019)

OSF is a benign lesion of resident CD34- and Factor XIIIa-positive spindle cells in the conjunctiva and Tenon's capsule. We have called to attention another lesion to be included by clinicians in the differential diagnosis of benign ocular surface lesions composed of CD34- and Factor XIIIa-positive spindle cells.
Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester). (1986)

We have conducted a Phase I and initial clinical pharmacological evaluation of LM985, the first of a series of compounds based on the flavone ring structure to be considered for clinical trial in malignant disease. The drug was administered i.v. to 26 patients with advanced cancer on an every-21-day schedule. Patients were treated at 14 dosage levels ranging from 10 to 1500 mg/m2. Dose limiting toxicity was identified as acute reversible hypotension occurring during drug infusion; no leukopenia, alopecia, hepatic toxicity, or renal toxicity was observed, but at the higher dose range, mild sedation was apparent. Twenty patients had measurable disease and were evaluable for response. One patient with colorectal carcinoma had stable disease after three courses of LM985; however, no other responses were seen. Pharmacokinetic and in vitro drug degradation studies imply that the ester LM985 is hydrolyzed to LM975 (flavone acetic acid) rapidly in vivo. LM975 is active in a variety of animal tumor models, but it does not have the cardiovascular side effects seen with LM985 (hypotension and bradycardia) in pithed or anesthetized rats. We would recommend that LM975 be considered for clinical trial, because it seems likely that substantially higher doses of LM975 than of LM985 can be given without dose limiting cardiovascular toxicity.