gebhart/patrepeval huggingface dataset:
Bridging to transplant by bronchoscopic lung volume reduction: Case reports of two COPD patients undergoing coil implantation (2014)

Background: Endoscopic lung volume reduction by coil implantation (ELVR-coil) improves pulmonary function and exercise capacity. Since the introduction of the lung allocation score (LAS) for patients awaiting lung transplantation, the total waiting time for COPD patients has increased. We investigated ELVR-coil therapy as bridging therapy to lung transplantation in end-stage COPD. Methods: Two COPD patients (baseline FEV1, 18% and 23%, residual volume (RV) 294% and 446% (all as % of predicted)) on the waiting list for lung transplantation were offered therapy by ELVR-coil in two sequential procedures. Follow-up after 3 months included the COPD Assessment Test (CAT), pulmonary function testing and a 6-min walking test (6MWT). Results: At the time of intervention, patients time on the waiting list for lung transplantation was 3 and 29 months. Each patient received 20 coils (10 on each side into both upper lobes). No treatment emerging adverse event was observed during the first 30 days after the procedure. During the 3 months follow-up, 1 exacerbation occurred and was treated in-hospital. Three months after ELVR-coil, mixed results were observed for the change in CAT (- 3 and +2) and FEV1 %pred. (+3.1% and -1.6%) while RV %pred. (-78% and - 39%) and 6MWT (+26m and +107m) improved substantially in both patients. Conclusions: ELVR-coil may offer a promising bridging option for selected COPD patients waiting for lung transplantation. After three months, partial improvements in pulmonary function and exercise capacity were noted in the presented cases. Future studies are warranted to assess the safety and efficacy in this selected patient cohort.
Gordon Research Conference on Chronobiology, 1995. (1995)

Abstract : The Gordon Research Conference on Chronobiology was held from April 30 till May 5 at the hotel II Cioccio, Barga, Italy. Applications for participation were received from 179 scientists, and 144 eventually attended the conference (Appendix A). Of these, 30.9% were graduate students and postdocs, and 41.7% were women. Countries of origin were distributed worldwide: 33% USA and Canada; 50% Western Europe; 4% Eastern Europe; 13% Australia, Asia, South America). Chronobiology is a strongly multidisciplinary field of research. This was reflected in the program of the conference, which spanned the breadth from human circadian rhythms to molecular analysis of rhythms in basteria. The program (appendix B) listed 25 speakers and 9 discussion leaders. In addition to the oral presentations there were four daily poster sessions, during which a total of 85 posters was presented. These were actively attended and led to vivid information exchange and many new contacts between research groups worldwide.
Induction of Polyamine Oxidase 1 by Helicobacter pylori Causes Macrophage Apoptosis by Hydrogen Peroxide Release and Mitochondrial Membrane Depolarization (2004)

Helicobacter pylori infects the human stomach by escaping the host immune response. One mechanism of bacterial survival and mucosal damage is induction of macrophage apoptosis, which we have reported to be dependent on polyamine synthesis by arginase and ornithine decarboxylase. During metabolic back-conversion, polyamines are oxidized and release H(2)O(2), which can cause apoptosis by mitochondrial membrane depolarization. We hypothesized that this mechanism is induced by H. pylori in macrophages. Polyamine oxidation can occur by acetylation of spermine or spermidine by spermidine/spermine N(1)-acetyltransferase prior to back-conversion by acetylpolyamine oxidase, but recently direct conversion of spermine to spermidine by the human polyamine oxidase h1, also called spermine oxidase, has been demonstrated. H. pylori induced expression and activity of the mouse homologue of this enzyme (polyamine oxidase 1 (PAO1)) by 6 h in parallel with ornithine decarboxylase, consistent with the onset of apoptosis, while spermidine/spermine N(1)-acetyltransferase activity was delayed until 18 h when late stage apoptosis had already peaked. Inhibition of PAO1 by MDL 72527 or by PAO1 small interfering RNA significantly attenuated H. pylori-induced apoptosis. Inhibition of PAO1 also significantly reduced H(2)O(2) generation, mitochondrial membrane depolarization, cytochrome c release, and caspase-3 activation. Overexpression of PAO1 by transient transfection induced macrophage apoptosis. The importance of H(2)O(2) was confirmed by inhibition of apoptosis with catalase. These studies demonstrate a new mechanism for pathogen-induced oxidative stress in macrophages in which activation of PAO1 leads to H(2)O(2) release and apoptosis by a mitochondrial-dependent cell death pathway, contributing to deficiencies in host defense in diseases such as H. pylori infection.
Taxonomy and physiology of Pseudoxanthomonas arseniciresistens sp. nov., an arsenate and nitrate-reducing novel gammaproteobacterium from arsenic contaminated groundwater, India (2018)

Reductive transformation of toxic arsenic (As) species by As reducing bacteria (AsRB) is a key process in As-biogeochemical-cycling within the subsurface aquifer environment. In this study, we have characterized a Gram-stain-negative, non-spore-forming, rod-shaped As reducing bacterium designated KAs 5-3T, isolated from highly As-contaminated groundwater of India. Strain KAs 5-3T displayed high 16S rRNA gene sequence similarity to the members of the genus Pseudoxanthomonas, with P. mexicana AMX 26BT (99.25% similarity), P. japonensis 12-3T (98.9 0%), P. putridarboris WD-12T (98.02%), and P. indica P15T (97.27%) as closest phylogenetic neighbours. DNA-DNA hybridization study unambiguously indicated that strain KAs 5-3T represented a novel species that was separate from reference strains of P. mexicana AMX 26BT (35.7%), P. japonensis 12-3T (35.5%), P. suwonensis 4M1T (35.5%), P. wuyuanensis XC21-2T (35.0%), P. indica P15T (32.5%), P. daejeonensis TR6-08T (32.0%), and P. putridarboris WD12T (22.1%). The DNA G+C content of strain KAs 5-3T was 64.9 mol %. The predominant fatty acids were C15:0 (37.4%), C16:0 iso (12.6%), C17:1 iso ω9c (10.5%), C15:0 anteiso (9.5%), C11:0 iso 3-OH (8.5%), and C16:1 ω7c/ C16:1 ω6c (7.5%). The major polar lipids were diphosphatidylglycerol, phosphatidyldimethylethanolamine, phosphatidylcholine, and two unknown phospholipids (PL1, PL2). Ubiquinone 8 (Q8) was the predominant respiratory quinone and spermidine was the major polyamine of the strain KAs 5-3T. Cells of strain KAs 5-3T showed the ability to use O2, As5+, NO3-, NO2-, and Fe3+ as terminal electron acceptors as well as to reduce As5+ through the cytosolic process under aerobic incubations. Genes encoding arsenate reductase (arsC) for As-detoxification, nitrate- and nitrite reductase (narG and nirS) for denitrification were detected in the strain KAs 5-3T. Based on taxonomic and physiological data, strain KAs 5-3T is described as a new representative member of the genus Pseudoxanthomonas, for which the name Pseudoxanthomonas arseniciresistens sp. nov. is proposed. The type strain is KAs 5-3T (= LMG 29169T = MTCC 12116T = MCC 3121T).
Chronic cyclooxygenase-2 inhibition does not alter blood pressure and kidney function in renovascular hypertensive rats (2003)

Celecoxib reduces the interstitial fibrosis of the clipped kidney. Blood pressure, urinary aldosterone excretion or whole kidney function were not affected in renal hypertensive rats.
Accurate Optoacoustic and Inertial 3-D Pose Tracking of Moving Objects With Particle Filtering (2019)

In industrial environments, the determination of the positions and orientations of tools in complex manual assembly processes allows an automated monitoring about the fulfillment of the process and a quality control. This contribution presents an optoacoustic indoor localization system based on combined distance and inertial measurements that is able to undertake this positioning task. In doing so, an accurate distance measurement is achieved with ultrasound and infrared. This novel system is able to localize multiple moving objects attached to transmitters simultaneously by measuring the unilateral distances to room-fixed receivers and fusing these measurements with inertial navigation system data (acceleration, angular velocity, and magnetic field) in a particle filter (PF). In doing so, the PF is determining the objects' poses by using the accelerometer and gyroscope data for a pose prediction in a propagation step and by utilizing the distance measurement and magnetometer data for an estimation correction. A commercially available, optical reference system is used to record the dynamics of human hand movements in an assembly scenario in order to analyze these dynamics for a system performance evaluation. Subsequently, the novel, an optoacoustic system is tested by applying these dynamics to an electrical linear axis on which a transmitter is fixed. Compared to the reference system, the median position error achieved is below 2.6 cm and the median orientation error is less than 10.0°, even when going beyond the hand movement dynamics recorded previously.
CCDC 818912: Experimental Crystal Structure Determination (2011)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
4.6-W Single Frequency Semiconductor Disk Laser With <formula formulatype="inline"> <tex Notation="TeX">${&lt;}{\rm 75}\hbox{-}{\rm kHz}$</tex></formula> Linewidth (2012)

We report on a single frequency semiconductor disk laser producing 4.6 W of output power with the free-running linewidth of <;75 kHz derived from delayed self-heterodyne measurements. The implementation of the flip-chip gain design allows for considerable power scaling with good beam quality and high spectral purity.
Performance Measure Aggregation, Career Incentives, and Explicit Incentives (2009)

We examine a setting in which managers have differential career concerns and firm performance is publicly observed using disaggregated measures that are incrementally informative but costly to contract upon. In such a setting, when do firms contract on aggregated rather than disaggregated performance measures? We show that at intermediate levels of managerial career concerns contracting on an aggregate measure can be welfare-enhancing. In this case, the net cost of both contracting directly on an aggregate measure and exploiting career incentives based on disaggregated measures is smaller than the cost of contracting directly on disaggregate measures. Our findings also imply that detailed performance disclosures will be accompanied by lower incentive weights based on aggregate performance when career incentives mitigate distortions caused by aggregation. Further, if performance measures become noisier due to transient shocks, we find that contractual incentive weights on aggregate performance can be either increasing or decreasing, depending on the magnitude of a manager’s career incentives.
Transmission of 40-Gb/s x 8-WDM channels with 0.4-(bits/s)/Hz spectral efficiency using short-period dispersion-managed fiber (2002)

We report on the 320-Gb/s (40 Gb/s x 8 channels) WDM transmission experiment using short-period dispersionmanaged fiber. After 320-km transmission, the average Q-factor was measured to be better than 20.4 dB. In addition, we compared the performances of various types of fibers in 40-Gb/s based systems.
CONVERSATIONAL SKILLS OF INDIVIDUALS WITH FRAGILE‐X SYNDROME: A COMPARISON WITH AUTISM AND DOWN SYNDROME (1991)

The conversational skills of 18 individuals with fragile-X syndrome (FXS) were compared with those of two other matched groups with autism and Down syndrome. The FXS group used more eliciting forms in conversation than those with Down syndrome, and also used partial self-repetition more often than the other two groups. The Down syndrome group had more speech dysfluencies than those with autism, but not more than those with FXS. The autistic group used more inappropriate phrases. Qualitative analysis of behavioral phenotype may reveal differences in communicative organization among subgroups whose retardation is based on different genotypes. In addition, analysis of verbal strategies during conversation suggests important differences between individuals with FXS and autism.
Frequency phenomenon and algorithms for arc detection (2010)

Successful detection of power line arcing requires various algorithms from frequency domain to time domain analysis. This paper explores frequency phenomenon that when analysed with a defined set of algorithms can distinguish between arcing noise and typical power line noise associated with distribution hardware and various noise-generating loads. These techniques may be applied to measuring conducted and radiated emissions in the electromagnetic environment. They may also be applied to H and E fields resulting from the spreading of distribution lines within a secondary power-distribution system down inside a manhole. The promising quick detection and identification from laboratory and actual field measurements is necessary and critical to ensure life-safety for manhole workers during maintenance activities.
VDP Quality aspects on fibre based packaging : An elementary print quality study on corrugated board (2010)

Variable data printing (VDP) is a technique whereby certain information can be altered in an otherwise static layout with the help of a digital printing system, and in the packaging industry a wide ...
The chelation of metal ions by dipeptides and related substances. Part 4.—The complexes of some sarcosyl and leucyl compounds with some divalent metal ions (1959)

S. P. Datta, R. Leberman and B. R. Rabin, Trans. Faraday Soc., 1959, 55, 1982 DOI: 10.1039/TF9595501982
Synthesis of Metal‐Oxide Nanoparticles: Gas–Solid Transformations (2006)

This chapter contains sections titled: Part One—Chemical Vapor Deposition Part Two—Pulsed Laser Deposition References
Anwendungspotential Biologischer Glycolipide (2002)

Die in den vorhergehenden Kapiteln beschriebenen Biotenside können wegen der z. Zt. noch zu hohen Herstellungkosten mit etablierten chemischen Produkten kaum konkurrieren. Anwendungspotentiale eröffnen sich aber dort, wo die biologische Herkunft eine bessere Biokompatibilität und gute mikrobielle Abbaubarkeit verspricht. [Kesting et al. 1996] Diese Kriterien werden besonders gefordert bei großräumigen Eingriffen in die Natur, z.B. bei der tertiären Erdölförderung und der Dekontaminierung von ölhaltigen Arealen, [Banat 1995] im Pflanzenschutz, im kosmetischen Pflegebereich [Klekner & Kosaric 1993] und auf dem pharmazeutischen Sektor. Daher ist es nicht überraschend, dass gerade für diese Anwendungsgebiete eine Reihe von Labor- und auch Feldversuchen beschrieben werden.
Laboratory tests with acoustic intensity measurements including the effect of reverberant environment (1980)

The purpose of the work was to find the effect of microphone type, size, distance, sensitivity, stability, mounting, and other possible effects on the precision of the intensity measurement by using the cross-spectral method. The calibration was conducted in a spherical sound field generated by a small loud-speaker baffled by a tube. The low frequency range of the measurement is limited by phase mismatch of the two channels while the microphone distance affects the upper frequency limit of usability. The paper will also discuss the intensity measurements in a reverberant environment.
ON THE IMMUNE SERUM AGAINST FOOTAND-MOUTH DISEASE (1922)

1. Calves subjected to a natural infection proved to be immune against subcutaneous inoculation of virulent blood carried out 20-34 days after their recovery. To determine the duration of the immunity produced by the natural infection further investigations are necessary.2. Subcutaneous inoculation of blood, saliva, vesicular content, and emulsion of spleen and lymphatic gland from an infected animal produced the disease in the calves experimented on. The minimum dose of virulent blood for a calf was 2c.c.3. The blood-serum taken from the animal recovered from one attack of this disease was found to have a protective action which can be intensified by repeated injections of the virulent blood (100, 500, 1000c.c.)4. The period of incubation in this disease is sometimes as short as 24 hours. To test, therefore, the protective action of an immune serum, injection of serum first and of virus one or two days later is preferable to the injection of both at the same time.5. The animals treated with the immune serum in a dose of 0, 53c.c. per kilo body-weight proved to be immune against injection of 10c.c. of virulent blood carried out 3 weeks later. To determine the relation between the dose of serum and the duration of immunity further investigations are necessary.
An Improved Measurement Placement Algorithm for Network Observability (2001)

This paper presents a fast method for multiple measurement placement for systems that are found to be unobservable. Upon placement of multiple measurements, all observable islands will be merged together and the entire system will be rendered fully observable. The method uses a test matrix whose leading dimension is determined by the rank deficiency of the gain matrix. Therefore, even for very large systems, as long as the number of measurements to be placed is relatively low, the proposed method will maintain its computational advantage. Compared to the existing iterative approaches, this method directly provides the entire set of additional measurements for placement. The method is developed based on the authors' previous work [4] where a direct method for observability analysis was presented.
A strabismus susceptibility locus on chromosome 7p (2003)

Strabismus has been known to have a significant genetic component, but the mode of inheritance and the identity of the relevant genes have been enigmatic. This paper reports linkage analysis of nonsyndromic strabismus. The principal results of this study are: (i) the demonstrated feasibility of identifying and recruiting large families in which multiple members have (or had) strabismus; (ii) the linkage in one large family of a presumptive strabismus susceptibility locus to 7p22.1 with a multipoint logarithm of odds score of 4.51 under a model of recessive inheritance; and (iii) the failure to observe significant linkage to 7p in six other multiplex families, consistent with genetic heterogeneity among families. These findings suggest that it will be possible to localize and ultimately identify strabismus susceptibility genes by linkage analysis and mutation screening of candidate genes.
Application of Scavengers for the Removal of Palladium in Small Lot Manufacturing (2008)

Scavengers are useful for the removal of palladium from organic products originating from palladium catalyzed reactions. Their ease of use and reliable performance with low risk for byproduct formation make them excellent candidates for early-phase process development efforts. A workflow for development of Pd scavenging process is described from screening to implementation. A small volume (1 mL) screening protocol is described and compared to a literature method. Screening experiments employ analysis by ICP/MS and HPLC to identify hits for further evaluation and process development. Some scavengers, including certain polypropylene bound scavengers and trimercaptotriazine, have a marked influence of temperature on Pd removal efficiency, making room temperature screening unreliable. Other scavengers, including some silica bound scavengers were less dependent on temperature under the screening protocol. Process development studies define the reaction progress of removing Pd, the influence of scavenger loading and the loss of product to adsorption. Demonstration of Pd scavenging on multi-kilogram production scale is described.
Design of an ultra-directive antenna using spatial coordinate transformation (2009)

Spatial coordinate transformation is used as a reliable tool to control electromagnetic fields. In this paper, we derive the permeability and permittivity tensors of a metamaterial able to transform a dipole source radiating isotropically to an ultra-directive antenna. We show how its directivity is enhanced when the wavelength is sufficiently small compared to the width of the metamaterial. Numerical simulations using Comsol Multiphysics are performed to illustrate these properties.
High spin states and isomers in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Dy</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>151</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math> (1979)

High spin states and isomers in $^{151}\mathrm{Dy}$ have been studied using the $^{122}\mathrm{Sn}$($^{32}\mathrm{S}$,$3n$)$^{151}\mathrm{Dy}$ and $^{141}\mathrm{Pr}$($^{14}\mathrm{N}$,$4n$)$^{151}\mathrm{Dy}$ reactions. Levels up to $J=\frac{53}{2}$ have been assigned, and two isomers at 4904 keV ($J=\frac{41}{2}$, ${\ensuremath{\tau}}_{\frac{1}{2}}=7\ifmmode\pm\else\textpm\fi{}2$ ns) and 6032 keV ($J=\frac{49}{2}$, ${\ensuremath{\tau}}_{\frac{1}{2}}=10.9\ifmmode\pm\else\textpm\fi{}0.6$ ns) have been identified. Gamma transitions de-exciting the isomers have $B(E2)$ values characteristic of single-particle transitions. The yrast sequence exhibits an irregular dependence on excitation energy characteristic of an independent particle model rather than a deformed rotor. In addition, above $J=\frac{25}{2}$ it exhibits an effective moment of inertia of 138 Me${\mathrm{V}}^{\ensuremath{-}1}$ which is 1.18 times the rigid sphere value. These data are compared to recent spherical and deformed shell model predictions and a qualitative agreement is found between experiment and calculation.NUCLEAR REACTIONS $^{122}\mathrm{Sn}$($^{32}\mathrm{S}$,$3n$) $^{151}\mathrm{Dy}$, $E=115\ensuremath{-}165$ MeV; $^{141}\mathrm{Pr}$($^{14}\mathrm{N}$, $4n$) $^{151}\mathrm{Dy}$, $E=60\ensuremath{-}101$ MeV. Measured $\ensuremath{\sigma}(E)$, $I(\ensuremath{\theta})$, $\ensuremath{\gamma}\ensuremath{-}\ensuremath{\gamma}$ coinc. with pulsed beam. Deduced levels, branching ratios, spin assignments, lifetimes. Enriched targets, Ge(Li) detectors. Comparison with spherical and oblate spheroidal model calculations.