gebhart/patrepeval huggingface dataset:
<i>In vitro</i> anti‐HSV‐2 activity and mechanism of action of proanthocyanidin A‐1 from <i>Vaccinium vitis‐idaea</i> (2004)

Abstract The aim of this study was to investigate the in vitro anti‐HSV‐2 activity and mechanism of action of proanthocyanidin A‐1, a compound isolated from Vaccinium vitis‐idaea Linn (Ericaceae). The results demonstrated that proanthocyanidin A‐1 exhibited anti‐HSV‐2 activity. The IC 50 value for the XTT assay was 73.3 ± 14.5 µ M and the IC 50 and IC 90 values for the plaque reduction assay were 41.9 ± 2.0 and 62.8 ± 6.3 µ M respectively. Proanthocyanidin A‐1 showed no cell cytotoxic effect at concentrations that blocked HSV‐2 infection, with a CC 50 value of 282.1 ± 27.5 µ M . The mechanism studies demonstrated that proanthocyanidin A‐1 did not reduce viral infectivity but inhibited viral attachment and penetration and affected the late stage(s) of HSV‐2 infection. It was concluded that proanthocyanidin A‐1 suppressed HSV‐2 infection through many modes of action and thus merits further investigation. Copyright © 2004 Society of Chemical Industry
Partitioning in Aqueous Two-Phase Systems: Fundamentals, Applications and Trends (2014)

Over the last years, aqueous two-phase systems (ATPS) regained an increasing interest due to their potential in the downstream processing of biomolecules. After many years with only a few articles published, a lot of effort and work has been put into studying these systems for the partitioning of a range of compounds including proteins, organic low-molecular weight molecules or metal ions. Although several research and review articles appeared, a background review on ATPS partitioning fundamentals is needed. In this article, partitioning theories and main effects of several important factors for partitioning, such as molecular weight of the polymer, effect of added salts, pH, electrical charges, and temperature on phase diagrams, tie-line lengths, interfacial tension and settling time of the two aqueous phases are extensively reviewed. The trend in ATPS research is given compiling the recent 2008–2013 research articles published in the field.
SIMERO: Sichere Mensch-Roboter-Koexistenz (2003)

Den in der industriellen Produktion eingesetzten Manipulatoren fehlt in der Regel die Moglichkeit, ihre Umwelt wahrzunehmen. Damit Mensch und Roboter in einem gemeinsamen Arbeitsraum arbeiten konnen, wird im SIMERO-System die Transferbewegung des Roboters durch Kameras abgesichert. Dieses Kamerasystem wird auf Ausfall uberpruft. Dabei werden Fehler in der Bildubertragung und Positionierungsfehler der Kameras betrachtet.
Forward Secrecy in Password-Only Key Exchange Protocols (2002)

Password-only authenticated key exchange (PAKE) protocols are designed to be secure even when users choose short, easilyguessed passwords. Security requires, in particular, that the protocol cannot be broken by an o-line dictionary attack in which an adversary enumerates all possible passwords in an attempt to determine the correct one based on previously-viewed transcripts. Recently, provably-secure protocols for PAKE were given in the idealized random oracle/ideal cipher models [2, 8, 19] and in the standard model based on general assumptions [11] or the DDH assumption [14]. The latter protocol
On the inverse kinematics of an underwater vehicle-manipulator system (2012)

The inverse kinematics plays an important role in the trajectory planning and the control of underwater vehicle-manipulator system. The solutions of this problem have an important influence on the motion quality of end-effectors. This paper presents an improved method based on the Jacobian matrix and the error feedback. By using this method, the accuracy of the solution of inverse kinematics for the vehicle-manipulator system is improved. In addition, one of the advantages of a redundant system is exploited to avoid impact on joint limitations. Numerical simulations in software Matlab are carried out to verify the efficiencies of the proposed method.
METRo: A New Model for Road-Condition Forecasting in Canada (2001)

A numerical model to forecast road conditions, Model of the Environment and Temperature of Roads (METRo), has been developed to run at Canadian weather centers. METRo uses roadside observations from road weather information systems stations as input, together with meteorological forecasts from the operational Global Environmental Multiscale (GEM) model of the Canadian Meteorological Centre; the meteorologist can modify this forecast using the “SCRIBE” interface. METRo solves the energy balance at the road surface and the heat conduction in the road material to calculate the temperature evolution; it also accounts for water accumulation on the road in liquid and solid form. Radiative fluxes reaching the surface are taken from the GEM model in automatic mode or are parameterized as a function of cloud cover and temperature when run in manual mode. The road-condition forecast is done in three stages: initialization of the road temperature profile using past observations, coupling of the forecast with observations during the overlap period when the meteorological forecast and the roadside observations are both available, and the forecast itself. The coupling stage allows for adjusting the radiative fluxes to local conditions. Results for road temperature are presented for three stations in Ontario for a period of 3 months. The 24-h forecasts are issued 2 times per day at 0300 and 1500 LT. Overall, about one-half of the time the error in surface road temperature (verified every 20 min) is within ±2 K, and the nighttime rms error is about 2 K. The impact of the coupling stage is large and allows METRo to produce automatic forecasts almost as good as the manual ones, especially for the first few hours. When METRo is run in manual mode, several nearby stations can use the same meteorological input, saving preparation time for the meteorologist. METRo also contains a mechanism for correcting systematic errors at each station, and it is hoped that this capability will permit its application to many new sites without major adjustments.
Error compensation and uncertainty evaluation of CMMs based on kinematic error models and gaussian processes (2016)

This thesis was submitted for the degree of Masters of Philosophy and awarded by Brunel University London.
A novel image/video coding method based on Compressed Sensing theory (2008)

Compressed Sensing (CS) has been recently proposed for more efficient signal compression and recovery at theoretical level. This paper proposes a new image/video coding approach combining the CS theory into the traditional discrete cosine transform (DCT) based coding method to achieve better compression efficiency for spatially sparse signal. Furthermore, this new approach is integrated into JPEG and H.264/AVC coding framework as a new coding mode. Rate-distortion optimization is employed for adaptive selection between the new coding mode and the conventional coding modes. Experimental results demonstrated remarkable coding gain for different kinds of natural image/videos by the proposed method.
Highly efficient biotransformation of ginsenoside Rb1 and Rg3 using β-galactosidase from Aspergillus sp. (2015)

β-Galactosidase from <italic>Aspergillus</italic> sp. can transform major ginsenoside Rb1 to rare ginsenoside F2 <italic>via</italic> ginsenoside Rd. Ginsenoside Rg3 can be selectively hydrolyzed with this β-galactosidase and only ginsenoside Rh2 was obtained as well.
Efficient Colorimetric Assay of RNA Polymerase Activity Using Inorganic Pyrophosphatase and Ammonium Molybdate (2009)

3Therefore, continuous hydrolysis of pyrophosphate by pyrophophatases can enhance the yield of RNA or DNA synthesis during the nucleic acid polymerization. We have set out the experiments to monitor the activity of nucleic acids polymerase using the PPase, which can be applicable to a high-throughput screening of antiviral drugs against various viral RNA polymerases. Currently, activity assay of RNA polymerases is mainly based on the direct measurement of RNA polymerase’s incorporation of radioactive ribonucleotides in the synthesizing nucleic acids. Such radioactive assays cannot be easily adapted to high throughput screening. In our studies, the amounts of inorganic phosphate are to be quantitatively measured with color-developing reagent after the RNA polymerase reaction, which is generated from hydrolysis of pyrophosphates by the PPase. This colorimetric coupledenzyme system will facilitate measurement of RNA polymerase activity without need of cumbersome radioactivity assay.
A POS-based fuzzy word clustering algorithm for continuous speech recognition systems (2007)

Using word base n-gram language models in continuous speech recognition systems is so prevalent. For using this type of language models, we should extract them from large corpora. Since Persian corpora are not rich, therefore the extracted language models are not credible. For this reason, most researchers extract class n-grams instead of finding word n-grams. In this research a new idea for fuzzy word clustering is represented that each word can be assigned to more that one class. The Fuzzy c-mean algorithm is used for our clustering method and we have examined its various parameters of it. Finally, this algorithm was applied on 20000 most frequent Persian words extracted from ldquoPersian Text Corpusrdquo. The extracted language models are evaluated by perplexity criterion and the results show that a considerable reduction in perplexity has been achieved. Also, the results of this language model were evaluated on speaker independent continuous speech recognition system and improved the system accuracy.
CORRESPONDENCE (1963)

CORRESPONDENCE Get access JOHN, JOHN Search for other works by this author on: Oxford Academic Google Scholar LYNN SINDEN LYNN SINDEN University College of North Wales, Department of ForestryBangor, Caernarvonshire Search for other works by this author on: Oxford Academic Google Scholar Forestry: An International Journal of Forest Research, Volume 36, Issue 2, 1963, Pages 261–262, https://doi.org/10.1093/forestry/36.2.261 Published: 01 October 1963
Position synchronized path following for a mobile robot and manipulator (2013)

We solve a coordinated path following problem for a fully actuated revolute type robotic manipulator with 4 degrees-of-freedom and a dynamic unicycle. Each robot is assigned a simple closed curve in its output space. The robots must approach and traverse their assigned curves while synchronizing their positions along the paths. Synchronization entails enforcing a positional constraint between the robots modeled as a constraint function on the paths. After characterizing feasible constraints, a finite-time stabilizing control law is used to enforce the position constraint. A switching rule is introduced to avoid singularities introduced by our control laws.
Approaches to the Analysis of Spectral Decomposition for the Purpose of Detailed Geological Interpretation (2016)

Abstract This article considers qualitative and quantitative interpretation of spectral decomposition results on the basis of a deposit in Western Siberia. Spectral decomposition as a method of time-frequency analysis is getting extensively used in geophysical during recent years. This fact makes relevant to consider geological structure prediction algorithms on spectral amplitude characteristics. The study proposes a new approach to the interpretation of spectral data – frequency pseudo-cube, which on the one hand allows to optimize interpretation process, on the other hand, allows to use new analysis technics such as principal component analysis and cluster analysis. Approaches to interpretation discussed on a single case that allows to perform a comparative analysis of the methods and to determine the most informative one within particular subject of study.
Regulation of the <i>Escherichia coli</i> heat‐shock response (1993)

Steady-state- and stress-induced expression of Escherichia coli heat-shock genes is regulated at the transcriptional level through controls of concentration and activity of the positive regulator, the heat-shock promoter-specific subunit of RNA polymerase, sigma 32. Central to these controls are functions of the DnaK, DnaJ, GrpE heat-shock proteins as negative modulators that mediate degradation as well as repression of activity and, in some conditions, of synthesis of sigma 32. DnaJ has a key role in modulation since it binds sigma 32 and, jointly with DnaK and GrpE, represses its activity. Furthermore, DnaJ is capable of binding heat-damaged proteins, targeting DnaK and GrpE to these substrates, and thereby mediating DnaK-, DnaJ-, GrpE-dependent repair. It is proposed that one important signal transduction pathway that converts stress to a heat-shock response relies on the sequestering of DnaJ through binding to damaged proteins which derepresses and stabilizes sigma 32. Damage repair ameliorates the inducing signal and frees DnaJ, DnaK, GrpE to shut off the heat-shock response.
Double‐blind and placebo‐controlled study to assess efficacy and safety of a modified allergen extract of <i>Dermatophagoides pteronyssinus</i> in allergic asthma (2005)

After 1 year of treatment, the modified extract of D. pteronyssinus demonstrated to be safe and efficacious to treat patients with asthma and allergic rhinoconjunctivitis sensitized to this mite.
STUDIES ON THERMAL BEHAVIOUR OF TETRAALKOXYSILANES (1989)

Tetraalkoxysilanes (Compounds A to O) were prepared by reacting SiCI4 with corresponding alcohols in the liquid phase in the presence of pyridine as acid acceptor in benzene solvent. Based on the experimental evidences and theoretical calculations tentative structures had been proposed. Properties such as density, refractive index, viscosity, surface tension, molecular weight, thermal expansion, specific heat, thermal conductivity, decomposition temperature and oxidation stability were determined. Prandtl number, Reynold's number and heat transfer coefficient for tetraalkoxysilanes were calculated and were compared with those of coolanols of Monsanto Chemicals, USA. Thermal stability of the compounds was studied by heating them at 200°C for 100 hours in the presence and in the absence of phenyl-a-naphthylamine and diphenylamine as stabilizers and redetermining some of the properties like density, refractive index, surface tension, viscosity and molecular weight The variation of the properties due to heat treatment is less significant when they are heated in the presence of a stabilizer. The low variation of physical constants by heat treatment particularly in the presence of a stabilizer suggests that these compounds are thermally stable and can be used in heat transfer and other thermal applications with stabilizers
Quantitative phase contrast imaging of cells by multi-wavelength digital holography (2007)

Quantitative phase contrast images of cells are generated by multi-wavelength phase imaging digital holography. Two or more wavelengths are used for simultaneous illumination of the cells and real-time acquisition of holographic images.
A rising war on terrorists (1989)

Technology for detecting and preventing acts of terrorism is addressed. Attention is directed toward methods for detecting explosives. The one technology, thermal-neutron activation (TNA), that has so far proven that it can quickly and reliably detect specified quantities of explosives within luggage and divert suspect bags without human intervention is described. Promising alternatives to TNA, which is very expensive, are resonance absorption of gamma rays and fast neutron activation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Red Municipal de Atención a la Infancia (2004)

La Red de Atención a la Infancia recibió el premio Cataluña Educación del año 2002, otorgado por el Departament d'Educació de la Generalitat de Catalunya por la labor de promoción educativa entre las familias del municipio
Planning for Contingencies: A Decision-based Approach (1996)

A fundamental assumption made by classical AI planners is that there is no uncertainty in the world: the planner has full knowledge of the conditions under which the plan will be executed and the outcome of every action is fully predictable. These planners cannot therefore construct contingency plans, i.e., plans in which different actions are performed in different circumstances. In this paper we discuss some issues that arise in the representation and construction of contingency plans and describe Cassandra, a partial-order contingency planner. Cassandra uses explicit decision-steps that enable the agent executing the plan to decide which plan branch to follow. The decision-steps in a plan result in subgoals to acquire knowledge, which are planned for in the same way as any other subgoals. Cassandra thus distinguishes the process of gathering information from the process of making decisions. The explicit representation of decisions in Cassandra allows a coherent approach to the problems of contingent planning, and provides a solid base for extensions such as the use of different decision-making procedures.
Mutagenesis of the L7 Loop Connecting β Strands 12 and 13 of Calcineurin:  Evidence for a Structural Role in Activity Changes (1997)

Calcineurin is a heterodimer consisting of a catalytic A-subunit and a B-subunit, and is regulated by binding of calmodulin and calcium. The C-terminus of the A-subunit contains an autoinhibitory domain which plays an important role in regulation of calcineurin activity. In this study, we have mutated the L7 loop connecting beta strands 12 and 13 in calcineurin A. These mutants included two chimeric mutants in which a four amino acid stretch in the cognate L7 loops of the related proteins phosphatase-1 (GEFD) or -2A (YRCG) were substituted for the calcineurin sequence DVYN (313-316), a point mutation (L312C), and a truncated mutant in which the YRG sequence replaced residues 313-316. Examination of the activities of these mutants led to the striking finding that truncation of the loop region by one residue resulted in hyperactivation of the calcineurin A-subunit. That the hyperactivation is due to conformational effects on the catalytic core of the enzyme was established since this effect was maintained in truncation mutants (at residues 456 and 388) in which the calmodulin and autoinhibitory domains were deleted. These studies provide evidence that the L7 loop is an important structural element in the conformation of the active site, and may participate in the conformational transitions of calcineurin between a catalytically repressed state and an activated state under the influence of the B-subunit.
Immunoassay Methods (1989)

The U.S. Environmental Protection Agency (EPA) has designated the Environmental Monitoring Systems Laboratory, Las Vegas, Nevada (EMSL-LV), as the EPA laboratory responsible for evaluating the application of immunochemical methods to environmental monitoring. To facilitate this designation, guidelines for evaluating immunoassay methods have been developed. These guidelines address criteria which should be met by the developer before an evaluation study is undertaken. The criteria addressed include: quality control; standard operating procedures; documentation of assay performance; data quality objectives; and supplies of specific antibody, antigen, and hapten. The degree of fulfillment of these criteria influence the design of the evaluation study. If only a few of the criteria are met, a preliminary evaluation will be conducted. These evaluation studies assist the developer to ultimately configure an assay appropriate for environmental monitoring. If the assay that is submitted to the EMSLLV is well characterized, a single- or multi-laboratory evaluation may be conducted. For assays that are very mature and well-characterized, a short laboratory confirmation followed by an on-site field demonstration may be appropriate. Evaluation results are used to assess the application of immunochemical methods for environmental analysis.
El artículo 1 de la LJCA y el control judicial de la aplicación, en España, del Derecho comunitario (2005)

Este trabajo ha sido seleccionado y ha obtenido el Accésit Premio Estudios Financieros 2005 en la Modalidad de DERECHO ADMINISTRATIVO. La Sala de lo Contencioso-Administrativo del Tribunal Supremo viene entendiendo en su jurisprudencia que los tribunales españoles no pueden ejercer el control de adecuación de las leyes con las directivas que desarrollen o introduzcan, pues se lo veda el artículo 1 de su ley jurisdiccional. Esta jurisprudencia es contraria a la jurisprudencia del Tribunal de Justicia de las Comunidades Europeas y desconoce el papel del juez nacional como juez comunitario. Cualquier ciudadano puede dirigirse al juez nacional con la pretensión de que inaplique normas internas contrarias al Derecho comunitario, y el juez nacional, por su propia jurisdicción, debe proceder a la inaplicación de la norma interna incompatible. En el presente artículo se analiza críticamente dicha jurisprudencia de la Sala de lo Contencioso-Administrativo del Tribunal Supremo, a la luz de la jurisprudencia del Tribunal de Justicia de las Comunidades Europeas y de la doctrina, que es prácticamente unánime y contraria a la posición del Tribunal Supremo español.
A proposal for <i>p</i>-type ZnS1-<i>x</i>Se<i>x</i>–ZnTe superlattices (1985)

Energy band structures ZnSe–ZnTe and ZnS0.5Se0.5 –ZnTe superlattices are calculated using the Kronig-Penney model taking into account strain effects due to the lattice mismatches between the materials. The ZnSe(30 Å)–ZnTe(5 Å) and the ZnS0.5Se0.5 (30 Å)–ZnTe(5 Å) superlattices have energy gaps of 2.5 and 2.7 eV, respectively. The ZnS0.5Se0.5 (30 Å)–p-type ZnTe(5 Å) superlattice is considered to be a p-type material of 1017 cm−3 and to be available for a hole injection layer to an n-type ZnSe layer.
Interactions between 12-EO<i><sub>x</sub></i>-12 Gemini Surfactants and Pluronic ABA Block Copolymers (F108 and P103) Studied by Isothermal Titration Calorimetry (2003)

The interactions between triblock copolymers of poly(ethylene oxide) and poly(propylene oxide), P103 and F108, EO(n)PO(m)EO(n), m = 56 and n = 17 and 132, respectively, and gemini surfactants (oligooxa)-alkanediyl-alpha,omega-bis(dimethyldodecylammonium bromide) (12-EO(x)-12), x = 0-3, have been studied in aqueous solution using isothermal titration calorimetry. The thermograms of F108 as a function of surfactant concentration show one broad peak at polymer concentrations, Cp, < or =0.50 wt %, below the critical micelle concentration (cmc) of the copolymer at 25 degrees C. It is attributed to interactions between the surfactant and the triblock copolymer monomer. The critical aggregation concentration (cac) remains constant while deltaHmax2 and the saturation concentration, C2, increase with increasing copolymer concentration. Analysis of the cac data offers semiquantitative support that the degree of ionization of the surfactant aggregates bound to polymers is likely to be larger than that at the surfactant cmc. In P103 solutions at Cp > or = 0.05 wt %, two peaks appear in the thermograms and they are attributed to the interactions between the gemini surfactant and the micelle or monomeric forms of the copolymer. An origin-based nonlinear fitting program was employed to deconvolute the two peaks and to obtain estimates of peak properties. An estimate of the fraction of copolymer in aggregated form was also obtained. The enthalpy change due to interactions between the surfactants and P103 aggregates is very large compared to values obtained for traditional surfactants. This suggests that extensive reorganization of copolymer aggregates and surrounding solvent occurs during the interaction. Dehydration of the copolymers by the surfactant may also play an important step in the interaction. The endothermic enthalpy change reflecting interactions between the surfactant and polymer decreases more rapidly as the length and hydrophilic character of the spacer increases, suggesting that more favorable interactions occur with the P103 monomers having shorter PEO segments.