gebhart/patrepeval huggingface dataset:
Effects of hypothalamic and amygdaloid lesions on development and growth of carcinogen-induced mammary tumors in the female rat. (1969)

The effects of median eminence and preoptic and amygdaloid lesions on normal and 7,12-dimethylbenzanthracene-induced neoplastic mammary tissue growth were investigated in female Sprague-Dawley rats. Marked stimulation of normal and neoplastic mammary tissue growth was observed in intact rats 10 and 25 days after placement of median eminence lesions. When median eminence lesions and ovariectomy were combined, a striking stimulation of normal and neoplastic tissue was noted 10 days but not 25 days later. If ovariectomy preceded the median eminence lesions by 10 days, no effect was observed on neoplastic mammary growth, and only a slight stimulation of normal mammary growth was observed 10 days after lesion placement. Since lesions in the median eminence result in enhanced prolactin secretion and reduced secretion of all other anterior pituitary hormones, these observations indicate that prolactin is the principal hormone responsible for growth of the 7,12-dimethylbenzanthracene-induced mammary tumors. Lesions in the preoptic or amygdaloid complex of intact rats induced marked tumor regression 10 or 25 days after lesion placement, but they apparently had no effect on normal mammary development 10 days after lesion placement. The reduction in mammary tumor growth was accompanied by decreased ovarian and uterine weights, suggesting that estrogen secretion was lowered. Since the latter can result in diminished prolactin secretion, it is possible that reduced secretion of estrogen and prolactin was responsible for the mammary regression observed in the le-sioned rats.
The Promise and Pitfalls of Going into the Field (2003)

Firsthand reports from the field comprise some of the most valuable work in the social sciences. But findings are often controversial. Understanding how fieldwork is carried out can help readers assess ethnographic research.
We All Make Mistakes One Day I'll Be Free Thirty-Five Years to Life (2005)

Editor's Note: At the age of sixteen, Duc Ta was convicted of first-degree attempted murder. He was driving a car when one of his passengers fired a gun at two other teens, but no one was hurt. In spite of no prior arrests or convictions, Duc was treated as an adult in the criminal justice system and sentenced to thiry-five years to life. In June 2004, Duc was granted a new sentencing hearing. The gang enhancement charge was dropped and the gun charge was re-evaluated. He was re-sentenced to eleven years to life.
Crystallization of Bowman-Birk Type Protease Inhibitor (Peanut) and Its Complex with Trypsin1 (1986)

Crystallization and preliminary crystallographic study of Bowman-Birk type protease inhibitors, A-I, A-II, and B-III from peanut seeds (Arachis hypogaea), and of the A-II + trypsin complex were carried out. A-II, with 70 amino acid residues, crystallizes in a trigonal system, P3(1)21 (or P3(2)21), a = 71.8, c = 65.9 A, Z = 12 or 18. The A-I crystal is isomorphous with that of A-II, indicating that the N-terminal residues are in a disordered state in both crystals. The B-III crystal is monoclinic, C2, a = 119.6, b = 69.6, c = 94.2 A, beta = 115.1 degrees, Z is about 40. The A-II + trypsin complex crystallizes in an orthorhombic system, P2(1)2(1)2(1), a = 55.5, b = 56.0, c = 182.1 A, Z = 4.
Membrane domain structures of three classes of histidine kinase receptors by cell-free expression and rapid NMR analysis (2010)

NMR structural studies of membrane proteins (MP) are hampered by complications in MP expression, technical difficulties associated with the slow process of NMR spectral peak assignment, and limited distance information obtainable for transmembrane (TM) helices. To overcome the inherent challenges in the determination of MP structures, we have developed a rapid and cost-efficient strategy that combines cell-free (CF) protein synthesis, optimized combinatorial dual-isotope labeling for nearly instant resonance assignment, and fast acquisition of long-distance information using paramagnetic probes. Here we report three backbone structures for the TM domains of the three classes of Escherichia coli histidine kinase receptors (HKRs). The ArcB and QseC TM domains are both two-helical motifs, whereas the KdpD TM domain comprises a four-helical bundle with shorter second and third helices. The interhelical distances (up to 12 A) reveal weak interactions within the TM domains of all three receptors. Determined consecutively within 8 months, these structures offer insight into the abundant and underrepresented in the Protein Data Bank class of 2-4 TM crossers and demonstrate the efficiency of our CF combinatorial dual-labeling strategy, which can be applied to solve MP structures in high numbers and at a high speed. Our results greatly expand the current knowledge of HKR structure, opening the doors to studies on their widespread and pharmaceutically important bacterial signaling mechanism.
APT CCDTL and CCL thermal/mechanical analysis (2002)

Design automation techniques are being, developed to facilitate the design of the normal conducting Coupled-Cavity Drift Tube LINAC (CCDTL) and Coupled-Cavity LINAC (CCL) for the Accelerator Production of Tritium (APT). The cavity geometry is generated from automated RF design codes and fed directly into a 3-D multiphysics code which calculates the RF heat loads and cavity distortions due to the heat loads. The resulting frequency change in the cavity is determined by the Slater perturbation formulation. Cooling is located to minimize these distortions. The application and their status as applied to the APT CCL will be discussed. In particular, the use of specific codes to reduce the peak thermal stress around the coupling slots in these cw (continuous wave) RF cavities will be presented.
Iron(II) complexes with unsubstituted saturated tetraaza macrocyclic ligands of varying ring size (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIron(II) complexes with unsubstituted saturated tetraaza macrocyclic ligands of varying ring sizeDarrell D. Watkins, Dennis P. Riley, John A. Stone, and Daryle H. BuschCite this: Inorg. Chem. 1976, 15, 2, 387–393Publication Date (Print):February 1, 1976Publication History Published online1 May 2002Published inissue 1 February 1976https://pubs.acs.org/doi/10.1021/ic50156a029https://doi.org/10.1021/ic50156a029research-articleACS PublicationsRequest reuse permissionsArticle Views260Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the bit complexity of minimum link paths (1996)

All of the linear-time algorithms that have been developed for minimum-link paths use the real RAM model of computation. If one considers bit complexity, however, merely representing a minimum-link path may require a superquadratic number of bits. This paper considers bounds on the number of links (segments) needed by limited-precision approximations of minimum-link paths: When vertices are restricted to "first-derived" points, the number of links can increase by a constant factor; when they are restricted to points of an N x N grid, the number of links can increase by @(log N). 1 stance in which representing path vertices with rational
Model-Checking Real-Time Control Programs. Verifying LEGO Mindstorms Systems Using UPPAAL (1999)

In this paper, we present a method for automatic verification<br />of real-time control programs running on LEGO <br />RCX bricks using the verification tool UPPAAL. The control<br />programs, consisting of a number of tasks running concurrently,<br />are automatically translated into the timed automata<br />model of UPPAAL. The fixed scheduling algorithm<br />used by the LEGO RCX processor is modeled in UPPAAL,<br />and supply of similar (sufficient) timed automata<br />models for the environment allows analysis of the overall<br />real-time system using the tools of UPPAAL. To illustrate<br />our techniques we have constructed, modeled and verified<br />a machine for sorting LEGO bricks by color.
Channel structures observed in natural diamonds, synthetic moissanite, and synthetic quartz (2002)

Internal growth and dissolution features are visual characteristics of some natural, synthetic, and treated gem materials. Open channels or need-like structures are occasionally observed in natural diamond, synthetic moissanite (SiC-6H), and chemically-etched synthetic colorless quartz. The distinguishing features among the channel structures in these materials are compared, and possible formation mechanisms of the channels associated with dislocations or dislocation bundles are discussed.
Abstract P2-09-10: Feasibility Assessment of Pharmacogenomic Predictors Developed from Breast Cancer Cell Lines To Predict Breast Cancer Patient Pathological Response in Neoadjuvant Chemotherapy (2010)

Abstract Background: Studies of developing pharmacogenomic predictors from cancer cell lines to predict cancer patient clinical response and outcome to chemotherapy have yielded both positive and negative results. The variability in these results may arise from the noise inherent of microarray technology as well as the small sample size of in cell line studies. Therefore, it is greatly needed to evaluate the feasibility of using cell lines to develop pharmacogenomic predictors of patient pathological response. Material and Methods: Thirty breast cancer cell lines were exposed to 10 concentrations of paclitaxel-5-fluorouracil-doxorubicin-cyclophosphamide (TFAC) to measure in vitro chemosensitivity. Two independent and publicly available microarray datasets (Hoeflich and Neve) on these breast cancer cell lines together with the chemosensitivity results were used to identify pharmacogenomic predictors from each dataset. Two independent clinical trials (Hess and Popovici) with publically available data, having 130 and 100 patients respectively, were used as test sets to validate the accuracy of the pharmacogenomic predictors. All patients received TFAC as neoadjuvant therapy and the gene expression profiles of patients were assessed before receiving chemotherapy treatment. The patient's pathological complete response (pCR) was determined after treatment to evaluate the chemotherapy efficacy. The pharmacogenomic predictors developed from each of the cell line studies were evaluated for their ability to predict patient pCR in each of the clinical trials using the supervised principle component regression method. Results: The pharmacogenomic predictors identified from the Hoeflich and Neve cell line data (training sets) predicted pCR of the patients in the two clinical trials (test sets) with 64%-68% accuracy, 70%-87% sensitivity, and 60%-67% specificity when 100 genes were selected as pharmacogenomic predictors (Table 1). Conclusions: The four independent prediction results generated in this study demonstrate the feasibility of using breast cancer cell lines to identify pharmacogenomic predictors of response to chemotherapy treatment for breast cancer patients. Future studies will examine the use of drug responses from primary cultures of patient tumors to develop pharmacogenomic predictors of breast cancer patient responses to chemotherapy treatment. Table 1. Prediction of breast cancer patients’ pCR by pharmacogenomic predictors derived from breast cancer cell lines. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-09-10.
OH PLIF and Soot Volume Fraction Imaging in the Reaction Zone of a Liquid-Fueled Model Gas-Turbine Combustor (2004)

Simultaneous measurements of OH planar laser-induced fluorescence (PLIF) and laser-induced incandescence (LII) are used to characterize the flame structure and soot formation process in the reaction zone of a swirl-stabilized, JP-8-fueled model gas-turbine combustor. Studies are performed at atmospheric pressure with heated inlet air and primary-zone equivalence ratios from 0.55 to 1.3. At low equivalence ratios (φ &lt; 0.9), large-scale structures entrain rich pockets of fuel and air deep into the flame layer; at higher equivalence ratios, these pockets grow in size and prominence, escape the OH-oxidation zone, and serve as sites for soot inception. Data are used to visualize soot development as well as to qualitatively track changes in overall soot volume fraction as a function of fuel-air ratio and fuel composition. The utility of the OH-PLIF and LII measurement system for test rig diagnostics is further demonstrated for the study of soot-mitigating additives.
Performance of single and multi-user detection techniques for a MC-CDMA system over channel model used for HIPERLAN2 (2002)

The performance of a multi-carrier code division multiple access (MC-CDMA) system in the downlink is studied over HIPERLAN2 channels representative of indoor environment. Performance results of MC-CDMA systems are presented for different single user (SU) and multi-user (MU) equalization techniques. The influence of channel coding and frequency interleaving is evaluated for both systems. For MU detectors, channel decoding has been also used in order to improve MAI cancellation in the iterative process. Simulations results are presented.
Molecular orientational dynamics in solid C70: Investigation by one- and two-dimensional magic angle spinning nuclear magnetic resonance (1993)

We present the results of 13C nuclear magnetic resonance (NMR) measurements that probe molecular orientational dynamics in solid C70 in the temperature range 223–343 K. Orientational dynamics affect the NMR line shapes and spin–lattice relaxation rates by modulating the 13C chemical shift anisotropy (CSA). Motionally averaged CSA line shapes, determined from both one-dimensional and two-dimensional magic angle spinning NMR spectra, and relaxation rates are determined for each of the five inequivalent carbon sites in the C70 molecule. Comparisons of the results for the five sites provide evidence for rapid uniaxial molecular reorientation in the monoclinic (T≤280 K) and rhombohedral (280≤T≤330 K) phases and rapid isotropic reorientation in the face-centered cubic (T≥330 K) phase. The orientational correlation time is roughly 2 ns at 250 K and of the order of 5 ps at 340 K.
Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: The class II cytokine receptors and their ligands in mammals and fish (2003)

We propose a scheme for the evolution of HCII and their receptors during the radiation of bony vertebrates and suggest that the diversification that played an important role in the fine-tuning of the ancestral mechanism for host defense against infections probably followed different pathways in amniotes and fish.
Is surgery for aortic stenosis justified in patients over 75 years of age? (1996)

despite an operative mortality rate much higher than in patients under 70, AVR for CAS is justified even in patients over 75 years as it offers a good quality of survival and a life expectancy identical to that of the general population of the same age.
Surface tension studies on novel allylic mono‐and dihydroxy fatty compounds. A method to distinguish<i>erythro/threo</i> diastereomers (1995)

Abstract The suitability of the selenium dioxide/ tert. ‐butyl‐hydroperoxide system for obtaining allylic mono‐ and dihydroxy fatty compounds has recently been reported. The surface tension of some selected products was determined in 1N NaOH and compared to that of some known materials, such as ricinoleic acid. The surface properties of the novel monohydroxy fatty acids are comparable or better than those of the reference materials. The critical micelle concentrations of the novel monohydroxy acids are in the range 10 −4 –10 −3 mol/L, depending on their structure. Furthermore, the monohydroxy acids were more effective when the hydroxy group was closer to the functional group at C1. Allylic dihydroxy acids also lowered the surface tension but less so than the monohydroxy compounds. The erythro and threo diastereomers of the allylic dihydroxy acids can be distinguished by surface tension, with the threo diastereomers possessing better surfactant properties. Mixtures of the novel hydroxy fatty acids are also effective, thus obviating the need for complete purification of the products. Side products such as enones, which are formed during the allylic hydroxylations, also lower the surface tension. The products may be suitable for use in microemulsions or as additives in various commercial products.
Discrimination of Isomers of Released <i>N-</i> and <i>O-</i>Glycans Using Diagnostic Product Ions in Negative Ion PGC-LC-ESI-MS/MS (2018)

Profiling cellular protein glycosylation is challenging due to the presence of highly similar glycan structures that play diverse roles in cellular physiology. As the anomericity and the exact linkage type of a single glycosidic bond can influence glycan function, there is a demand for improved and automated methods to confirm detailed structural features and to discriminate between structurally similar isomers, overcoming a significant bottleneck in the analysis of data generated by glycomics experiments. We used porous graphitized carbon-LC-ESI-MS/MS to separate and detect released N- and O-glycan isomers from mammalian model glycoproteins using negative mode resonance activation CID-MS/MS. By interrogating similar fragment spectra from closely related glycan isomers that differ only in arm position and sialyl linkage, product fragment ions for discrimination between these features were discovered. Using the Skyline software, at least two diagnostic fragment ions of high specificity were validated for automated discrimination of sialylation and arm position in N-glycan structures, and sialylation in O-glycan structures, complementing existing structural diagnostic ions. These diagnostic ions were shown to be useful for isomer discrimination using both linear and 3D ion trap mass spectrometers when analyzing complex glycan mixtures from cell lysates. Skyline was found to serve as a useful tool for automated assessment of glycan isomer discrimination. This platform-independent workflow can potentially be extended to automate the characterization and quantitation of other challenging glycan isomers. Graphical Abstract ᅟ.
Hexose metabolism in pancreatic islets: Sorbitol dehydrogenase activity in rat islet homogenates (1991)

SCOPUS: ar.j
Slow myosin heavy chain content of muscles measured by ELISA (1995)

Summary Equine type I muscle fibres were characterised in 14 muscles by enzyme‐linked immunosorbent assay (ELISA) with a monoclonal antibody specific for slow myosin heavy chains (MHC I). Slices of vastus lateralis, rectus femoris, biceps femoris, semitendinosus, semimembranosus, gluteus medius, gluteus superficialis, cutaneus trunci, masseter, triceps brachii, biceps brachii, deüoideus and diaphragm were obtained from a one‐year‐old Standardbred. For each muscle, 4 samples per slices were excised at different sites and 2 contiguous sub‐samples were immediately frozen in liquid nitrogen and stored at –80 °C until analysed. Muscle proteins were specifically extracted and analysed by ELISA. The MHC I content varied widely in the different muscles from cutaneus trunci (9%) to masseter (69%). A 3‐way analysis of variance showed that the MHC I content was different between muscles (P < 0.001) and within the sites studied (P < 0.01). The 2 contiguous sub‐samples were not different from each other (P > 0.05). It is concluded that the ELISA method allowed the accurate measurement of a wide range of MHC I in equine muscles. This technique is less time consuming than histological techniques and offers new applications for muscle fibre typing.
Modèles micromécaniques : effets de l'anisotropie et de l'hétérogénéité de la répartition des renforts dans un composite à particules (2000)

No abstract provided
Engineering Innovation in Biomedical Nanotechnology (2015)

The objective of this National Science Foundation (NSF)-funded undergraduate engineering training project is to introduce nanoscale science and engineering through an innovative use of a technical elective sophomore-level mechatronics course, followed by an Accreditation Board for Engineering and Technology (ABET)-mandated senior-level engineering capstone design project. A unique partnership between University of Arizona’s department of surgery, its neurosurgical division, and the College of Engineering presents a creative environment, where medical residents serve as mentors for undergraduate engineering students in developing product ideas enabled by nanotechnology. Examples include: a smart ventricular peritoneal (VP) shunt with flow-sensing; a bio-resorbable inflatable stent for drug delivery, and a hand-held non-invasive eye tonometer. Results from the first year of the student projects, as well as qualitative assessment of their experience, is presented. Several institutional challenges were also identified.
Thermal expansion of GaSb measured by temperature dependent x-ray diffraction (2010)

X-ray diffraction measurements were performed using a modified zone technique on Te-doped GaSb wafers, commonly used for molecular beam epitaxial growth, at temperatures between 32 and 546 °C to determine the thermal expansion. The authors found the thermal expansion to be very close to the data published by Bublik et al. [Phys. Status Solidi A 73, K271 (1982)]. Control measurements of the lattice constant of Si were found to agree with the results published by Okada and Tokumaru [J. Appl. Phys. 56, 314 (1984)] within our measurement error of ±2×10−4 Å. A fourth order polynomial, a(GaSb)(T)=6.0959+3.37×10−5T+5.63×10−8T2−1.29×10−10T3+1.05×10−13T4 (Å) (T in °C), was found to be a good fit to our data, while a linear fit with a constant thermal expansion coefficient of 7.17×10−6 K−1 was found to be a poorer fit.
Diffusion of phosphorus during rapid thermal annealing of ion-implanted silicon (1984)

The diffusion of ion-implanted phosphorus in silicon during rapid thermal annealing has been studied. Depending on the implant dose, we find two distinct kinds of diffusion behavior. For low dose (1×1014 cm−2) P+-implanted Si, a profile redistribution is observed which becomes observable at 900 °C for annealing times of 10 s, but which is temperature independent in the range 800–1150 °C. This initial redistribution is much more rapid than conventional diffusion coefficient data would predict. For high dose (2×1015 cm−2) P+ implanted and short time (10 s) annealed Si, the dopant profile broadening is strongly temperature dependent. The experimental profiles are in this case in agreement with concentration enhanced diffusion profiles.