gebhart/patrepeval huggingface dataset:
Spontaneous cell-mediated cytotoxicity in humans. Distribution and characterization of the effector cell. (1978)

Small pore size and hydrophobic nature of DD3R make this material a unique zeolite with high potential in industrial separation applications. However, the reproducible rapid synthesis of this zeolite is still a problem. In this work, a thorough assessment of different synthetic methods revealed that synthesis reproducibility relies on two main pillars: the use of properly cleaned autoclave liners and the synthesis composition. High quality DD3R crystals are obtained when KOH is used as a cleaning agent, eliminating memory effects, and when KF is used in the synthesis as a mineralizing agent. The effect of fluoride addition is investigated by use of several characterization techniques (13C, 19F and 29Si MAS-NMR and (2D) 29Si–1H correlation spectra), while monitoring the temporal crystallization of DDR. 29Si–1H NMR reveals that template molecules accommodated within the cages are sticking to these 8-ring windows through their amine group. High quality DD3R crystals are applied in the adsorptive separation of buta-1,3-diene and but-2-ene isomers, one of the most energy intensive separations in chemical industry. Mixture separation experiments revealed that the 8-ring apertures of the DD3R cages are only accessible to trans-but-2-ene and buta-1,3-diene, while excluding but-1-ene and cis-but-2-ene molecules, resulting in shape-selective separation in the presence of C4 mixtures.
INCREASED LEVEL OF HSP27 BUT NOT OF HSP72 IN HUMAN HEART ALLOGRAFTS IN RELATION TO ACUTE REJECTION1 (2000)

For the first time in humans with cardiac allograft rejection, increased expression of HSP27, which could be important for cardiac self-protection, was demonstrated. For the lack of increased HSP72 expression, the influence of the cyclosporine A treatment was discussed.
Immunoglobulins and some serum proteins in children with altered resistance coming from areas with variously polluted atmosphere. (1990)

In four areas with different types of atmospheric pollution 534 children of school age were examined for serum immunoglobulins (IgG, IgA, IgM and IgE), saliva IgA (sIgA), lysozymes (LYS) and acute phase reactants (alfa-l-antitrypsin - A1AT, alfa-2-macroglobulin -A2M, ceruloplasmin -CPL, transferrin - TRF). The children were divided into two groups: those with altered resistance (AR) comprising allergoses of all types and recurrent or persistent infections and those without the above health problems, i.e. healthy (H). There were more children with AR in areas with higher atmospheric pollution than in control areas. The frequency of AR was higher among boys than among girls. In the control area BN, a number of parameters in the AR group differed significantly from those in the H group. In areas with substantial atmospheric pollution these differences were generally less pronounced. Significant differences were found between the control and polluted areas in many indicators. In the area KO characterized by an intermediate degree of industrial pollution the means of the tested parameters were habitually elevated, whereas in the heavily polluted areas they were decreased. The most sensitive tests for evaluating differences between the areas were the levels of A1AT, LYS, and IgE, while the variations of sIgA, sLYS and CPL were less pronounced.
“Vertical” Inhibition of HER2 Yields Horizontal Gains in the Clinic (2015)

HER2-targeted therapy has moved beyond trastuzumab to include other monoclonals targeting the cell surface, receptor tyrosine kinase inhibitors of HER2, and antibody-drug conjugates. Afatinib, a small molecule receptor tyrosine kinase inhibitor, now joins the ranks of HER2-targeting agents in combination with trastuzumab. The combination brings new opportunities and challenges.
Malicious BGP hijacks: Appearances can be deceiving (2014)

BGP hijacking is a well known threat to the Internet routing infrastructure. There has been considerable interest in developing tools that detect prefix hijacking but such systems usually identify a large number of events, many of them being due to some benign BGP engineering practice or misconfiguration. Ramachandran et al. [1] and later Hu et al. [2] also correlated suspicious routing events with spam and claimed to have found evidence of spammers temporarily stealing prefixes to send spam. In an effort to study at large scale the existence and the prevalence of malicious BGP hijacks in the Internet we developed a system which (i) identifies hijacks using BGP, traceroute and IRR data and (ii) investigates traffic originating from the reported networks with spam and netflow data. In this paper we present a real case where suspicious BGP announcements coincided with spam and web scam traffic from corresponding networks. Through this case study we show that a correlation of suspicious routing events with malicious activities is insufficient to evidence harmful BGP hijacks. We thus question previously reported cases and conclude that identifying malicious BGP hijacks requires additional data sources as well as feedback from network owners in order to reach decisive conclusions.
Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA. (1994)

We have previously shown that human B lymphocytes cultured in the CD40 system, composed of an anti-CD40 mAb presented by a CD32-transfected fibroblastic cell line, proliferate but do not secrete antibodies. However, the addition of particles of Staphylococcus aureus Cowan (SAC) induces B cell differentiation even in the absence of exogenous cytokines (CD40/SAC system). Additionally, B lymphocytes cultured in the CD40 system in the presence of human IL-10, produce IgM, IgG, and IgA, and Ig levels are further increased by SAC. Here, we have studied the capacity of peripheral blood lymphocytes from patients with IgA deficiency (IgA-D) to secrete Igs, particularly IgA after CD40 triggering. Peripheral blood mononuclear cells (PBMNC) from IgA-D patients cultured in the CD40/SAC system produced IgM and IgG, but not IgA. The addition of IL-10 to the cultures, enhanced the production of IgM and IgG and most strikingly induced the production of high amounts of IgA. The addition of IL-10 to PBMNC from IgA-D patients activated through CD40 alone resulted in the production of IgA. Thus, SAC and anti-CD40 mAb stimulate B cells to differentiate into cells secreting IgG and IgM whereas IL-10 plays a central role in inducing B cells from IgA-D patients to differentiate into IgA secreting cells.
Effect of crystallinity of condensation polymers on platelet adhesion (1981)

Abstract Various polyamides and polyesters having different numbers of methylene groups in their repeating units have been synthesized and their blood compatibilities have been evaluated in terms of the adhesion behavior of blood platelets on the surface of these condensation polymers by a micro‐sphere‐column method. The number of methylene groups in the repeating units of polyamides and polyesters influenced the adhesion behavior of platelets and there was an optimum number of methylene groups each in polyamides and polyesters. Poly(hexamethylene terephthalamide) and poly(pentamethylene terephthalate) adsorbed platelets in the smallest number in the polyamide and polyester series, respectively. Blood platelets were adsorbed on polyamides in smaller numbers than on corresponding polyesters. It was found that the platelet adhesion on the surface of polyamides and polyesters was closely related to their crystallinities and the number of the adsorbed platelets decreased linearly with increasing their relative crystallinity.
ChemInform Abstract: Studies on New Catechol Containing Cephalosporins. Part 1. Synthesis and Structure‐Activity Relationships of Cephalosporins Having a Catechol Moiety at the C‐3 Position. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Coherent acoustic phonons in silicon: propagation studies and imaging applications (2005)

We generate and detect coherent acoustic phonon pulses in Si using ultrafast optics. A unified model of diffractive, dispersive, and nonlinear propagation effects is developed and verified. Imaging using diffracted phonon pulses shows submicron resolution.
ChemInform Abstract: Glycosylidene Carbenes. Part 10. Regioselective Glycosidation of 4,6‐O‐ Benzylidene‐D‐altropyranosides. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The 2:1 Adduct of an α-L-Altropyranose Derivative with Hexafluoro-2,6-dihydroxy-2,6-bis(trifluoromethyl)-4-heptanone at 173 K (1995)

As reported earlier [Miethchen, Rentsch & Michalik (1994). Liebigs Ann. Chem. pp. 219-222], the structure of methyl 2-O-(cyclohexylcarbamoyl)-6-deoxy-3,4-O-(hexafluoroisopropylidene)-α-L-altropyranoside, C 17 H 23 F 6 NO 6 could be determined by X-ray analysis of a species which was obtained by co-crystallization with 1,1,1,7,7,7-hexafluoro-2,6-dihydroxy-2,6-bis(trifluoromethyl)-4-heptanone, C 9 H 6 F 12 O 3 , in a 2:1 molar ratio. While the pure α-L-altropyranose derivative forms needles that are not suitable for single-crystal X-ray investigations, the co-crystallization product yielded well shaped monoclinic prisms. The L-altropyranose derivative adopts a ring conformation which is intermediate between a boat and a twisted-boat conformation. The structure is stabilized by four intermolecular hydrogen bonds
A low‐power digital IC emulating intracellular calcium dynamics (2018)

Summary Low power/area cytomorphic chips may be interfaced and ultimately implanted in the human body for cell‐sensing and cell‐control applications of the future. In such electronic platforms, it is crucial to accurately mimic the biological timescales and operate in real time. This paper proposes a methodology where slow nonlinear dynamical systems describing the behaviour of naturally encountered biological systems can be efficiently realised in hardware. To this end, as a case study, a low power and efficient digital Application‐Specific Integrated Circuit capable of emulating slow intracellular calcium dynamics with timescales reaching to seconds has been fabricated in the commercially available AMS 0.35 μ m technology and compared with its analog counterpart. The fabricated chip occupies an area of 1.5 m m 2 (excluding the area of the pads) and consumes 18.93 n W for each calcium unit from a power supply of 3.3 V. The presented cytomimetic topology follows closely the behaviour of its biological counterpart, exhibiting similar time‐domain calcium ions dynamics. Results show that the implemented design has the potential to speed up large–scale simulations of slow intracellular dynamics by sharing cellular units in real time.
Prevention of human cell transformation by CAPE (caffeic acid phenethyl ester): Role of NF-κB factors. (2006)

B105 A chronic (8-week) exposure to 0.1 μM arsenite (As), a human environmental carcinogen, transforms human osteosarcoma (HOS) cells. When cells are concomitantly treated with As and 0.5 μM CAPE, cell transformation does not occur. Gene arrays and Western blots showed that in comparison to parental HOS cells, As causes many changes in gene expression, including down-regulation of inflammatory cytokine mRNAs, p53, and antioxidant enzyme mRNAs, as well as their protein products. Concurrently, levels of NF-κB p50/p105 mRNAs and proteins were also severely suppressed, which could explain a decrease in inflammatory factors, while p65 was not significantly changed quantitatively. However, small differences in molecular weight of p65 became apparent between the parental and transformed-HOS cells suggesting post-transcriptional modification. When HOS cells were exposed to As+CAPE for 8 weeks, cells did not grow in soft agar and CAPE preserved about 25-40% of p50/p105 levels present in HOS cells treated only with CAPE. Parental HOS cells contained p100 but not p52. Cells treated with As showed a strong increase in p52 and about a 4-fold decrease in p100. CAPE partially reversed As-mediated changes by restoring p100 and decreasing p52 about 2-fold. These results show that when p50/p105 of NF-κB1 are depleted, inflammatory factors, such as cytokines and chemokines, are also decreased, however, p52 of NF-κB2 is strongly up-regulated and likely plays an anti-apoptotic role. Co-treatment with CAPE reverses As-induced changes, including cell transformation, NF-κB1 & 2, p53, SOD1, NQO1, and induces apoptosis of transformed cells. Knockdown of p50 in parental HOS cells using p50 siRNA caused 60-70% decrease in p50 but had no effect on any other NF-κB factors. Our results proved that p50 is responsible for the regulation of inflammatory cytokines or their receptors, IL-8 (chemotactic & angiogenic factor), EGF, MIP, and some MMPs, all of which were decreased in the p50-knockout cells, while VEGF (vascular endothelial growth factor), a factor inducing angiogenesis, was increased. These data mimic many As-mediated changes. In summary, our data reflect a two-pronged CAPE-mediated NF-κB modulation: transcriptional regulation and post-transcriptional modification, which counteracts arsenite-induced transformational changes. These properties point to CAPE as a potential preventive and/or therapeutic agent that is effective at very low doses in controlling signal transduction pathways and cell transformation. [Supported in part by NIH grants ES10344 & ES00260]
Optimal Purification of Single Qubits (1999)

We introduce a new decomposition of the multiqubit states of the form ${\ensuremath{\rho}}^{\ensuremath{\bigotimes}N}$ and employ it to construct the optimal single qubit purification procedure. The same decomposition allows us to study optimal quantum cloning and state estimation of mixed states.
Hydrogen storage properties of hydrogenated graphite destabilized by mixing with lithium hydride (2007)

Hydrogen storage properties of the ball-milled mixtures composed of hydrogenated nano-structural graphite (CnanoHx) and lithium hydride (LiH) were examined from thermodynamic and structural points of view, where the CnanoHx was synthesized by ball-milling graphite powder under hydrogen atmosphere. Since hydrogen atoms in the CnanoHx and LiH are strongly bonded with each host atom, heating up to >600°C is necessary to release hydrogen from each solid product. The CnanoHx and LiH composites desorbed hydrogen and hydrocarbon gases below 400°C with about 9.4 mass% weight loss. The 2: 1 composite of the CnanoHx and LiH reversibly stored hydrogen with an effective capacity of about 4.5 mass % at 350°C. No evident peaks were observed in XRD profiles after the dehydrogenation, indicating that the nano-structural feature remained after dehydrogenation due to formation of (CLi) nano clusters. However, only the LiH phase was crystallized after rehydrogenation at 350°C. From these results, it is concluded that hydrogen in the composites is destabilized by a novel interaction between the CnanoHx and LiH in a nanometer scale, and is desorbed at lower temperatures than each of the components. Therefore, this Li-C-H system can be recognized to be a new family of hydrogen storage materials.
Real-time Fetal ECC Extraction (2005)

This paper presents an adaptive on-line technique for the real-time extraction of the antepartum Fetal Electrocardiogram (FECG) from cutaneous recordings. The method combines a number of cutaneously recorded potential signals in order to eliminate the omnipresent strong maternal ECG (MECG) and to detect an optimal FECG. The algorithm for this signal separation is based on the Singular Value Decomposition (SVD) of the data matrix. Crucial for the success of the method is an appropriate electrode placement strategy. At the moment a realtime PC-based unit for bed-side monitoring of the antepartum FECG is under development.
CARRIER PHASE SURVEYING WITH GARMIN HANDHELD GPS RECEIVERS (2001)

GRINGO (GPS RINEX Generator) is a program which has been developed at the Institute of Engineering Surveying and Space Geodesy (IESSG) at the University of Nottingham, to record the pseudorange and carrier phase data from 12-channel Garmin handheld GPS receivers, in standard RINEX (Receiver INdependent Exchange) format. It offers owners of these receivers the possibility of post-processing to an accuracy of approximately 5 m (with pseudoranges) or a few cm (with carrier phase), without having to invest in separate DGPS receiving equipment or expensive survey-grade receivers. They retain the benefits of an inexpensive receiver with a user-friendly interface and powerful navigation features, but gain the possibility of improved accuracy if needed.A number of experiments have been carried out to assess the accuracy of positioning with Garmin raw measurement data.Experiments over a 3 km baseline with various session lengths have shown that float solutions with the Garmin carrier phase can achieve better than 20 cm in 15 minutes, and approximately 5 cm with 30 minutes. Ambiguity fixed solutions can achieve approximately 1 cm accuracy in 30 minutes. A zero baseline test, with two garmin receivers attached to a single static antenna, has shown that under ideal conditions, even sub-millimetre accuracies are possible in as little as 10 minutes.Over a longer baseline (>200 km), the effects of the atmosphere on the measured baseline become significant. A comparison of one such baseline against simultaneous measurements with geodetic receivers has confirmed that the atmosphere affects the Garmin receivers in the same way as it does the geodetic receivers.This paper will present the results of these and other experiments.
IMPACT OF ELEMENTAL SULFUR FERTILIZATION ON AGRICULTURAL SOILS. II. EFFECTS ON SULFUR-OXIDIZING POPULATIONS AND OXIDATION RATES (1988)

Effects of elemental sulfur fertilization on sulfur-oxidizing populations, rhodanese activity, total sulfur content and sulfur oxidation rates in the 0- to 15-cm zone of two Grey Luvisolic soils were assessed. Heterotrophic sulfur oxidizers were the most abundant sulfur oxidizers detected in both soils. Elemental sulfur fertilization caused an increase in populations of autotrophic thiosulfate-oxidizing micro-organisms, and a threefold increase in rhodanese and sulfur-oxidizing activity in a Waitville soil. In contrast, sulfur fertilization did not stimulate autotrophic thiosulfate oxidizers in a Loon River soil and the greatest increase in rhodanese and sulfur oxidation rates was only 31%. The response to sulfur application was biphasic however, and subsequent additions of sulfur fertilizer resulted in a decline in oxidation rates. Total sulfur content of sulfur-treated soils indicated that most of the sulfur applied was still present in the sampled zone. These results imply that prediction of sulfate release and fertilizer efficiency will be difficult to assess. Key words: Sulfur (elemental), S-oxidation, oxidation rates, rhodanese, sulfur-oxidizing micro-organisms
A Chebyshev method for calculating state-to-state reaction probabilities from the time-independent wavepacket reactant-product decoupling equations (1997)

Recently, Peng and Zhang have introduced the reactant-product decoupling (RPD) equations. These are an exact formulation of quantum mechanical reactive-scattering, whereby the Schrödinger equation is partitioned into a set of uncoupled equations, each of which describes the dynamics in one arrangement of the reaction. In this paper we derive an efficient method for solving the RPD equations which is based on the Chebyshev propagator. The derivation makes use of the recently derived time-independent wavepacket version of the RPD equations. We test the method by applying it to the collinear H+H2 reaction.
Multiple donor-derived leukemias in a recipient of allogeneic hematopoietic cell transplantation for myeloid malignancy (2020)

Key Points A patient with myelodysplastic syndrome was transplanted twice and developed clonally unrelated relapse each time in donor-derived cells. This case supports the concept that a leukemogenic marrow environment may predispose the transplant recipient to malignant transformation.
A Formal Approach to Adaptive Processes using Scenario-based Concepts (2007)

Several limbic structures influence copulatory behavior and contain receptors for estradiol and progesterone. In the present study, single neuron activity was recorded from septal, amygdaloid, and other limbic regions during the hormonal induction of lordosis in behaving golden hamsters. Limbic neurons had low firing rates and a small number showed firing associated with orienting, sniffing, and rearing. Progesterone administration to estradiol-primed hamsters produced the following neuronal effects: a reduction in the number of active neurons and narrowing of dynamic activity range; enhanced neuronal responsiveness to face stimulation; and lordosis-correlated firing, consisting of depressed activity during lordosis and increased firing at response onset or offset. Unlike previously studied midbrain and hypothalamic neurons, control progesterone injections that didn't produce lordosis were about as effective in altering limbic neuronal activity levels and sensory responsiveness as behaviorally effective injections. The progesterone effects on limbic neurons are consistent with previous evidence suggesting that these neurons tend to suppress lordosis. The significance of these results to hormone influences on epilepsy is discussed.
Noncontact Vibrational Measurement Technology of Steam Turbine Blade. (1992)

One of the important ways to increase reliability of the power plant is to measure the vibration of steam turbine blades in service operation. The measurement of the rotating blades is usually executed by strain gage, however, since the turbine has multiple stages, it is generally difficult to attach the strain gages to the rotating blades obtain signals from the gages, especially in the intermediate stages. Furthermore, gages and wirings must endure high centrifugal force of rotating blades, steam pressure, and moisture in the turbine under operation. This paper presents noncontact measurement technology Which measured the vibration of the steam turbine blades during operation using a laser beam installed in a stationary casing. Furthermore, this paper delineates technical problem in the measurement of the steam turbine blades, such as the Severe environment in which light is irregularly reflected, the durability of sensors, and small amplitude due to the shroud blade.