gebhart/patrepeval huggingface dataset:
In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength. (2003)

In metastatic colorectal cancer the oral 5-fluorouracil (5FU) prodrug capecitabine is used with increasing frequency as an alternative to i.v. 5FU administration. The rate of conversion of capecitabine into 5'deoxy-5-fluorouridine has been related to tumor response, and 5FU catabolites have been associated with 5FU-related systemic toxicity. Here we demonstrate for the first time that capecitabine, its metabolites 5'deoxy-5-fluorocytidine and 5'deoxy-5-fluorouridine, and its catabolites 5-fluoro-ureido-propionic acid, alpha-fluoro-beta-alanine, and alpha-fluoro-beta-alanine-bile acid conjugate can be monitored in vivo by (19)fluorine magnetic resonance spectroscopy ((19)F MRS) in the liver of patients with metastatic colorectal cancer. Moreover, we demonstrate an improved signal-to-noise ratio and spectral resolution of the (19)F MRS spectra when measurements are performed at 3 T field strength as compared with measurements at the common clinical field strength of 1.5 T. We conclude that assessment of capecitabine metabolism in patients by (19)F MRS is a promising noninvasive tool for the prediction of its efficacy and toxicity, especially at the now currently available clinical field strength of 3 T.
Poly(<scp>l</scp>-lysine)-<i>g</i>-poly(ethylene glycol) Layers on Metal Oxide Surfaces:  Surface-Analytical Characterization and Resistance to Serum and Fibrinogen Adsorption (2000)

Poly(l-lysine)-g-poly(ethylene glycol) (PLL-g-PEG) is a member of a family of polycationic PEG-grafted copolymers that have been shown to chemisorb on anionic surfaces, including various metal oxide surfaces, providing a high degree of resistance to protein adsorption. PLL-g-PEG-modified surfaces are attractive for a variety of applications including sensor chips for bioaffinity assays and blood-contacting biomedical devices. The analytical and structural properties of PLL-g-PEG adlayers on niobium oxide (Nb2O5), tantalum oxide (Ta2O5), and titanium oxide (TiO2) surfaces were investigated using reflection−absorption infrared spectroscopy (RAIRS), angle-dependent X-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion mass spectrometry (ToF-SIMS). The combined analytical information provides clear evidence for an architecture with the cationic poly(l-lysine) attached electrostatically to the oxide surfaces (charged negatively at physiological pH) and the poly(ethylene oxide) side chains extending out from the surface. The relative intensities of the vibrational modes in the RAIRS spectra and the angle-dependent XPS data point to the PLL backbone being located directly at and parallel to the oxide/polymer interface, whereas the PEG chains are preferentially oriented in the direction perpendicular to the surface. Both positive and negative ToF-SIMS spectra are dominated by PEG-related secondary ion fragments with strongly reduced metal (oxide) intensities pointing to an (almost) complete coverage by the densely packed PEG comblike grafts. The three different transition metal oxide surfaces with isoelectric points well below 7 were found to behave very similarly, both in respect to the kinetics of the polymer adlayer adsorption and properties as well as in terms of protein resistance of the PLL-g-PEG-modified surface. Adsorption of serum and fibrinogen was evaluated using the OWLS optical planar waveguide technique. The amount of human serum adsorbed on the modified surfaces was consistently below the detection limit of the optical sensor technique used (<1−2 ng cm-2), and fibrinogen adsorption was reduced by 96−98% in comparison to the nonmodified (bare) oxide surfaces.
Synthesis and Properties of [A19-(<i>p</i>-Fluorophenylalanine)] Insulin (1988)

The synthesis of [Phe(F)A19]insulin (porcine) is described. First the protected [Phe(F)19]A-chain was assembled by segment condensation of [1-12] and [13-21] using the dicyclohexyldiimide/1-hydroxybenzotriazole procedure. [Phe(F)19]A-chain was purified by ion exchange chromatography after removal of all the protecting groups (Boc, But, OBut and S-Trt) and its conversion into the tetra-S-sulfonated derivative. [Phe(F)A19]insulin was prepared by combination with porcine B-chain and purified by gel filtration and ion-exchange chromatography. The in vitro biological activity of this analogue was 60%. CD spectra in the near and far UV are qualitatively very similar to those of insulin.
Matching Points into Pairwise-Disjoint Noise Regions: Combinatorial Bounds and Algorithms (1992)

We consider several cases of the point matching problem in which we are to find a transformation of a set of n points such that each transformed point lies in one of n given pairwise-disjoint “noise regions.” We prove upper and lower bounds on the number of possible matches, under a variety of types of transformations (rotations, translations, similarity) and noise regions (circles, squares, polygons). We also give efficient algorithms for computing the set of all possible matches, along with a corresponding transformation that realizes each match. INFORMS Journal on Computing, ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 to 1995 under ISSN 0899-1499.
Digital Watermarking Of Visual Data: State Of The Art And New Trends (2000)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
A New Method of Early Detection of Pregnancy in the Sow (1973)

A portable, compact electronic device has been developed to detect pregnancy in the sow. Accuracy has been reported to be 90-95 percent in the 30 to 80 day post conception sow or gilt. The instrument is able to detect fluid in the gravid uterus with ultra-sound waves. Diagnosis is rapid and can be made on the farm.
Hollow core terahertz optical fibers with hyperuniform disordered dielectric reflectors (2014)

A novel THz hollow-core optical fiber is proposed using as a reflector a hyperuniform disordered network of dielectric cylinders connected with thin dielectric walls.
The Influence of Interleukin-6 on the Growth of Human Esophageal Cancer Cell Lines (1996)

We reported that human esophageal cancer cell lines (ECC) (YES-1, -2, -3, -4, -5, and -6) produced interleukin-6 (IL-6). We, therefore, investigated the growth effects ([3H]thymidine uptake assay and direct cell count) of IL-6 on these ECC. IL-6 receptor (R) and GP-130 mRNA were detected in all the ECC, using reverse transcriptase-polymerase chain reaction (RT-PCR) assay, and IL-6R was detected in one (YES-3) by immunohistochemical staining. IL-6, anti-IL-6 monoclonal antibody (mAb), or anti-IL-6R mAb caused no reproducible enhancement or suppression of [3H]thymidine uptake by all six ECC. Direct cell count also revealed that the growth enhancement or suppression by IL-6, anti-IL-6 mAb, or anti-IL-6R mAb was relatively small. Particularly, there was no significant sensitivity of YES-3 cells, which definitely produce IL-6 and express IL-6R for IL-6, anti-IL-6 mAb, or anti-IL6R mAb. These results suggest that some esophageal cancers may produce IL-6 and express IL-6R. However, no major interactions between IL-6 and the growth of human esophageal cancer cell lines were detected in this study.
Oxidation of alkanes by dioxygen catalysed by photoactivated iron porphyrins (1991)

Cycloalkanes were oxidized by O2 itself under mild conditions (22 °C; 200 Torr of O2) in the presence of catalytic amounts of a polyhalogenated porphyrin–iron(III)—hydroxo complex irradiated with light of wavelength between 350 and 450 nm; these oxidations occurred without consumption of a reducing agent, selectively transformed cyclohexane into cyclohexanone under appropriate conditions (about 0. 2 turnover per min), and did not involve FeVO active species but, more probably, iron-alkylperoxo intermediates.
An Algebraic Approach to Dynamic Epistemic Logic (2010)

Abstract. Dynamic epistemic logic plays a key role in reasoning about multi-agent systems. Past approaches to dynamic epistemic logic have typically been focused on actions whose primary purpose is to communicate information from one agent to another. These actions are unable to alter the valuation of any proposition within the system. In fields such as security, it is easy to imagine situations in which this sort of action would be insufficient. We expand the algebraic framework presented by M. Sadrzadeh [14] to include both communication actions and dynamic actions that change the state of the system. Furthermore, we propose a new modality that captures both epistemic and propositional changes resulting from the agents ’ actions. 1
Spécificité anomérique du métabolisme glucidique (1988)

info:eu-repo/semantics/published
Ecology of the Tick Amblyomma hebraeum Koch in the Eastern Cape Province of South Africa. I. Distribution and Seasonal Activity (1977)

R. A. I. Norval, Ecology of the Tick Amblyomma hebraeum Koch in the Eastern Cape Province of South Africa. I. Distribution and Seasonal Activity, The Journal of Parasitology, Vol. 63, No. 4 (Aug., 1977), pp. 734-739
Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle (2017)

Enhanced coverage and sensitivity of next-generation 'omic' platforms has allowed the characterization of gene, metabolite and protein responses in highly metabolic tissues, such as, skeletal muscle. A limitation, however, is the capability to determine interaction between dynamic biological networks. To address this limitation, we applied Weighted Analyte Correlation Network Analysis (WACNA) to RNA-seq and metabolomic datasets to identify correlated subnetworks of transcripts and metabolites in response to a high-fat diet (HFD)-induced obesity and/or exercise. HFD altered skeletal muscle lipid profiles and up-regulated genes involved in lipid catabolism, while decreasing 241 exercise-responsive genes related to skeletal muscle plasticity. WACNA identified the interplay between transcript and metabolite subnetworks linked to lipid metabolism, inflammation and glycerophospholipid metabolism that were associated with IL6, AMPK and PPAR signal pathways. Collectively, this novel experimental approach provides an integrative resource to study transcriptional and metabolic networks in skeletal muscle in the context of health and disease.
Spectral Effects in the Comparison of Scintillators and Photomultipliers (1958)

Photomultiplier evaluation of scintillation performance is considered in the light of its marked dependence on spectral shape effects in the emission spectrum of the scintillator, in photon absorption of cell, reflector and photomultiplier window, and in the photoelectric conversion process. Relative pulse height data indicating gross differences in spectral sensitivity are presented for a group of 132 photomultipliers (types 6292 and 6342). A fluorescent converter for measuring the quantum output of liquid scintillators is described. Six scintillator solutions with fairly evenly spaced mean emission wavelengths from 3360 to 4660 A are evaluated for relative pulse height and relative photon output. Suggestions are presented for desirable methods for measuring the performance of scintillators.
Slug Detection As a Tool for Predictive Control of GLCC© Compact Separators (2001)

Abstract Current design and performance of the GLCC©1 separator is dependent on the prediction of the upstream inlet flow conditions based on available models. It is expected that early detection of terrain slugging (slug length, slug velocity and holdup) and controlling the liquid level in the GLCC using feed forward mechanism can improve the operational range of GLCC, by decreasing the gas carry under and liquid carry over, and thereby decreasing the control valve dynamics. The conventional feedback control loops can seldom achieve perfect control considering the impact of huge slugs that are keeping the output of the process continuously away from desired set point value. The reason is simple: a feedback controller reacts only after it has detected a deviation in the value of the level from the set point. Unlike the feedback systems, a feed forward control configuration measures the disturbance directly and takes control action to negate the effect of the disturbance on liquid level in the GLCC. Therefore, feed forward control system has the theoretical potential for perfect control if the slug detection and characterization are accurate. A strategy for GLCC predictive control has been proposed which integrates the feedback and feed forward loops to compensate for error due to modeling and slug characterization. A model has been developed for predictive control system design and simulated in MATLAB-Simulink®. Experimental results obtained demonstrate that the proposed strategy is a viable approach for GLCC predictive control.
Subpicosecond rectangular optical pulse generator using cascaded nonlinear directional couplers (2004)

We demonstrate numerically a novel method to generate rectangular optical pulses by nonlinear directional couplers. Single and cascaded coupler structures are investigated and it is shown that femtosecond rectangular-like pulses can be generated in a secondorder cascaded nonlinear directional coupler (NLDC) and subpicosecond ideal rectangular pulses could be achieved in a third-order cascaded NLDC. The influences of intermodal dispersion and higher order dispersion are included in the numerical analysis.
Discovery of <i>N</i>-(4-[<sup>18</sup>F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer (2019)

In Alzheimer's disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure-activity relationship exploration around an isoquinoline hit, followed by an exploration of tolerated fluorination positions, allowed us to identify 9 (JNJ-64326067), a potent and selective binder to aggregated tau with a favorable pharmacokinetic profile and no apparent off-target binding. This was confirmed in rat and monkey positron emission tomography studies using [<sup>18</sup>F]9.
STERIC STRAIN AND THE ANOMALOUS BASE STRENGTH OF THE NORMAL ALIPHATIC AMINES (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSTERIC STRAIN AND THE ANOMALOUS BASE STRENGTH OF THE NORMAL ALIPHATIC AMINESHerbert C. Brown and Moddie D. TaylorCite this: J. Am. Chem. Soc. 1944, 66, 5, 846–847Publication Date (Print):May 1, 1944Publication History Published online1 May 2002Published inissue 1 May 1944https://pubs.acs.org/doi/10.1021/ja01233a512https://doi.org/10.1021/ja01233a512research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Structural Damping Technique Based on Coupling Structures with Electronic Circuits (1999)

Abstract : This project investigated a novel active structural damping technique using PZT (lead zirconate titanate) patches as actuators/sensors and the internal resonance and saturation phenomena of multiple degree-of-freedom systems to suppress transient and steady-state vibrations of structures. The strategy consists of introducing second-order controllers and coupling them to the structure through a sensor and an actuator, where both the feedback and control signals are quadratic. Analytical, numerical, and experimental tasks have been performed to verify and demonstrate the efficiency of this technique. In the experiments, we successfully controlled the vibrations of a DC motor with a rigid bar attached, single-mode vibrations of beams, transient and steady-state vibrations of beams, multimode vibrations of beams using multiple electronic circuits, vibrations of skew cantilever plates. and machine-tool chatter by using analog and digital control systems. Moreover, we have derived and experimentally verified new nonlinear vibration absorbers using 2:1, 3:1, 4:1, and 4:2:1 internal resonances.
[COPD in the year 2005]. (2005)

COPD is a widespread illness with an increasing prevalence and mortality rate. Current knowledge of its pathophysiology has it that COPD is not simply limited to the lungs, but must be understood as a systemic inflammatory reaction. The ATS/ERS guideline goes beyond the recommendations of the GOLD guideline, and takes account of the peculiarities of the European and North American healthcare systems (www.ersnet.org). In this context, the role of inhaled steroids, which is currently still under lively discussion, has to be revisited. Additional possible approaches include the administration of appetite stimulants and dietary measures, and the application of iron or erythropoietin. The TORCH study--currently the largest ongoing COPD study--is investigating the influence of inhaled glucocorticoids and long-acting beta2 agonists on mortality.
Letters to the Editor (1997)

Medical School of the Technical University of Dresden; Department of Legal Medicine and Department of Traumatology; Dresden, Germany.
Über die Bedeutung uveitischer Symptome bei der Netzhautablösung (1981)

Bei rund ein Drittel von 315 operativ behandelten Netzhautablösungen wurden vermehrt Zellen im Kammerwasser und im Glaskörper beobachtet. In diesen Fällen lag die Zahl der Mißerfolge doppelt so hoch wie bei Patienten ohne uveitische Begleitsymptome der Ablatio retinae. Anhand von Beispielen wird gezeigt, daß nichtsteroidhaltige entzündungshemmende Medikamente, wie Diclofenac oder Oxyphenbutazon, die entzündlichen Begleiterscheinungen bei ungünstig verlaufenden Netzhautablösungen bessern können.
Extreme programming evaluation framework for object-oriented languages -- version 1.1 (2003)

The Extreme Programming development Methodology (XP) seems appropriate for some teams or projects. Anecdotal stories from developers who have tried XP are often favorable. However, there is little empirical evidence to support or refute claims regarding XP. The Extreme Programming Evaluation Framework (XP-EF) provides a benchmark measurement framework for researchers and practitioners to assess concretely the extent to which an organization has adopted XP practices and the result of this adoption. Through replication of case studies which utilize the structure of the XP-EF, the community can build an experience factory of empirical findings on XP; the results of these case studies can be integrated and combined. 1.
ChemInform Abstract: Formal Total Synthesis of 1β‐Methylcarbapenem via a Novel Route to Deoxyamino Sugars. (1989)

Abstract Starting with the pyranoside (I), the gluconolactone (VI) is synthesized via the key intermediates (II), (IV), and (V).
Hydrophobic surface protein masking by the opportunistic fungal pathogen Candida albicans (1992)

Ultrastructural and biochemical analyses of hydrophobic and hydrophilic yeast cell surface proteins of Candida albicans were performed. Hydrophobic and hydrophilic yeast cells were obtained by growth at 23 and 37 degrees C, respectively. In addition, hydrophilic yeast cells were converted to surface hydrophobicity by treatment with tunicamycin and dithiothreitol. When freeze-etched cells were examined, the temperature-induced hydrophilic cells had long (0.198 micron), compact, evenly distributed fibrils while temperature-induced hydrophobic cells had short (0.085 micron), blunt fibrils. Hydrophobic microsphere attachment to the hydrophobic cells occurred at the basement of and within the short fibril layer. Dithiothreitol-induced hydrophobic cells had the long fibrils removed; tunicamycin-induced hydrophobic cells retained some of the long fibrils, but the fibrils were less compact and more aggregated than the untreated controls. These results suggest that the long fibrils prevent hydrophobic microsphere attachment to the hydrophobic area of the cell surface. This was confirmed by assessing the hydrophobic avidity of hydrophobic yeast cell populations differing in fibril density and arrangement. 125I-labelled surface proteins from hydrophobic and hydrophilic cells were compared after separation by hydrophobic interaction chromatography-high-performance liquid chromatography and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography. The yeast cell populations had hydrophilic proteins of similar molecular masses (greater than 200 kDa), but the hydrophilic cells possessed at least two additional proteins (ca. 63 and 69 to 71 kDa). Hydrophobic surface proteins appeared to be similar. However, the amount of total radiolabelled hydrophobic proteins was approximately 10-fold higher for the hydrophobic cells than for the hydrophilic cells. This result agrees with the ultrastructural observations which showed that yeast cell surface hydrophobic proteins are masked by hydrophilic high-molecular-mass surface fibrils. Taken together, the data indicate that yeast cell hydrophobicity is not determined by differences in surface hydrophobic proteins but by the presence of hydrophilic, surface fibrils.
Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids (2018)

Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications. Cytosolic delivery is essential for their translation and self-replication, without infectious progeny generation, providing high levels of antigen expression for inducing humoral and cellular immunity. Synthetic nanoparticle-based delivery vehicles can both protect the RNA molecules and facilitate targeting of dendritic cells-critical for immune defense development. Several cationic lipids were assessed, with RepRNA generated from classical swine fever virus encoding nucleoprotein genes of influenza A virus. The non-cytopathogenic nature of the RNA allowed targeting to dendritic cells without destroying the cells-important for prolonged antigen production and presentation. Certain lipids were more effective at delivery and at promoting translation of RepRNA than others. Selection of particular lipids provided delivery to dendritic cells that resulted in translation, demonstrating that delivery efficiency could not guarantee translation. The observed translation in vitro was reproduced in vivo by inducing immune responses against the encoded influenza virus antigens. Cationic lipid-mediated delivery shows potential for promoting RepRNA vaccine delivery to dendritic cells, particularly when combined with additional delivery elements.
Facial paralysis rehabilitation: retraining selective muscle control (1982)

Traumatic facial paralysis can be improved with surgical techniques but alone will not restore full function. EMG sensory (bio) feedback can, however, facilitate rehabilitation. Four cases are described using a combined treatment technique of EMG, behavioural modification and specific action exercises. Retraining of eyelid control was also accomplished. Standardized evaluation methods are described. All four patients showed improvement, despite the failure of traditional retraining methods.