gebhart/patrepeval huggingface dataset:
Immunolymphoscintigraphy with Indium-111 labeled T101 monoclonal antibody (1985)

The authors have demonstrated specific modal and cutaneous uptake of In-111 T101 (a pan T-cell monoclonal antibody) after intravenous (IV) infusion into patients with cutaneous T-cell lymphoma (CTCL); however since animal studies have shown more efficient lymph node (LN) uptake after subcutaneous (SC) injection, this technique was applied to several patients with CTCL. Serial gamma camera images were obtained after SC injection of 500 ..mu..Ci In-111 T101 (100 ..mu..g, 500 ..mu..g or 1 mg) into the webs between the toes. Within minutes, lymphatic vessels in the legs as well as femoral, inguinal and iliac LN were visualized in all patients. Computer-analysis of serial images demonstrated that LN counts reached maximum at 24 hr and remained stable through 96 hr. At 24 hrs, femoral and inguinal LN collectively contained 18% to 51% of the injected dose (ID), and the injection site retained from 23% to 51% of the ID. In contrast to the results of IV injection, the liver, spleen, marrow and supradiaphragmatic LN (cervical, hilar, and axillary) contained much less radiolabel than did subdiaphragmatic LN. Inguinal lN biopsies showed up to 2% of the ID per gram. Low (100 ..mu..g) dose administration resulted in strong uptake in inguinal and iliacmore » LN with weak uptake in periaortic LN, whereas 500 ..mu..g and above produced strong uptake in all subdiaphragmatic LN. These findings suggest highly efficient binding in LN proximal to the injection site, followed by more distant uptake as the proximal sites approach saturation, and demonstrate that lymphatic delivery of monoclonal antibodies can be used to target cells in human LN.« less
[Effect of cyclophosphamide on bone remodeling in rats]. (2003)

Neoplasms, with or without metastases in bones, can induce pathological bone remodeling, leading to systemic bone resorption and hypercalcemia or osteomalacia and normocalcemia. The aim of the present study was to investigate the effect of a cytostatic--cyclophosphamide on the skeletal system in rats. The experiments were carried out in male Wistar rats with initial body weight of 212-229 g, divided into 3 groups (n = 6): I--Control, II--Cyclophosphamide (10 mg/kg m.c. i.m. daily for 14 days, and after a 7-day break, for 7 days), III--Cyclophosphamide (20 mg/kg m.c.p.o. daily for the initial 14 days). After 30 days of the experiment, the animals were killed and bone mass, length and diameter of long bones, mineral content in bones, transverse cross-section surfaces of the cortical diaphysis and of the marrow cavity, transverse growth, width of endosteal and periosteal osteoid in the tibia, width of trabeculae, width of epiphyseal cartilage and mechanical features of the femur were examined. Cyclophosphamide caused disorders of bone tissue remodeling. Decreases in bone mass, length, diameter, mineral content in bones, width of trabeculae in the femur, transverse growth, width of osteoid, transverse cross-section surface of the cortical diaphysis, and worsening of mechanical properties of the femur were observed.
Erraticity of sprinkler irrigated corn in 2011 (2012)

Presented at Proceedings of the 24th annual Central Plains irrigation conference held on February 21-22 in Colby, Kansas.
[Spontaneous growth of suspended hamster embryonic cells transformed in vitro by methyl-7 benzo(a)anthracene]. (1975)

A transformed and malignant cell line was obtained by treatment of secondary hamster embryo cells with 7-methyl benz(a)anthracene (10 mug/ml of medium). Later on these cells acquired the capacity to grow spontaneously in suspension and form "spheroids". The evolution of this cell line showed similarities between the carcinogenic process in vitro and in vivo.
STM-switching of organic molecules on semiconductor surfaces: an above threshold density matrix model for 1,5 cyclooctadiene on Si(100) (2012)

The scanning tunnelling microscope (STM)-induced switching of a single cyclooctadiene molecule between two stable conformations chemisorbed on a Si(100) surface is investigated using an above threshold model including a neutral ground state and an ionic excited state potential. Switching was recently achieved experimentally with an STM operated at cryogenic temperatures (Nacci et al 2008 Phys. Rev. B 77 121405(R)) and rationalized by a below threshold model using just a single potential energy surface (Nacci et al 2009 Nano Lett. 9 2997). In the present paper, we show that experimental key findings on the inelastic electron tunnelling (IET) switching can also be rationalized using an above threshold density matrix model, which includes, in addition to the neutral ground state potential, an anionic or cationic excited potential. We use one and two-dimensional potential energy surfaces. Furthermore, the influence of two key parameters of the density matrix description, namely the electronic lifetime of the ionic resonance and the vibrational lifetimes, on the ground state potential are discussed.
Factors influencing the presence of hemiparesis in chronic subdural hematoma (2019)

Presence of loculations, unilateral hematomas, older patient age, hematoma maximal thickness, and midline shift were associated with a higher rate of hemiparesis in CSDH patients. Moreover, 19.8 mm of hematoma thickness and 6.4 mm of midline shift were associated with a 50% probability of hemiparesis in patients with unilateral hematomas.
Fiber optic sensor: Feedback control design and implementation (1997)

Digital feedback control of Gas Tungsten Arc Welding (GTAW) has been demonstrated on a tube sample of stainless steel and titanium alloy. A fiber optic sensor returns a signal proportional to backside radiance from the workpiece; that signal is used by the controller to compute a compensation weld current. The controller executes 10 times a second on an Intel 486 chip. For travel speeds of 3 to 6 inches per minute and thicknesses between 0.025 and 0.10 inches, constant backside bead width was maintained within 0.02 inches, from startup to tie-in.
Efficient compression algorithm for file updates under random insertions and deletions (2016)

The problem of one-way file synchronization from the client to the data-center, namely, file updates, is studied. The problem is investigated in particular when an old version of a file which can be available at both client and data-center, is edited by the client to a new version. The edits are modeled as random insertions and deletions (InDels). Based on the updated and the previous version of the file, the client transmits a message to the data-center via a noiseless link, such that the data-center can update the file. A dynamic-programming-run-length-coding (DP-RLC) scheme is proposed for the message encoding in this paper. The lower order terms of the achievable rate are computed explicitly. It is worth noting that these terms match the information-theoretic lower bound derived in our previous work [1]. Therefore, when the insertion and deletion probabilities are small, the achievable rate is nearly optimal.
Differential expression of two <i>P5CS</i> genes controlling proline accumulation during salt‐stress requires ABA and is regulated by <i>ABA1, ABI1</i> and <i>AXR2</i> in <i>Arabidopsis</i> (1997)

Proline is a common compatible osmolyte in higher plants. Proline accumulation in response to water stress and salinity is preceded by a rapid increase of the mRNA level of delta 1-pyrroline-5-carboxylate synthase (P5CS) controlling the rate-limiting step of glutamate-derived proline biosynthesis. P5CS is encoded by two differentially regulated genes in Arabidopsis. Gene AtP5CS1 mapped to chromosome 2-78.5 is expressed in most plant organs, but silent in dividing cells. Gene AtP5CS2 located close to marker m457 on chromosome 3-101.3 contributes 20-40% of total P5CS mRNA in plant tissues, but is solely responsible for the synthesis of abundant P5CS mRNA in rapidly dividing cell cultures. Accumulation of AtP5CS transcripts is regulated in a tissue specific manner and inducible by drought, salinity, ABA, and to a lesser extent by auxin. Induction of AtP5CS1 mRNA accumulation in salt-treated seedlings involves an immediate early transcriptional response regulated by ABA signalling that is not inhibited by cycloheximide, but abolished by the deficiency of ABA biosynthesis in the aba1 Arabidopsis mutant. However, inhibition of protein synthesis by cycloheximide prevents the induction of AtP5CS2 mRNA accumulation, and blocks further increase of AtP5CS1 mRNA levels during the second, slow phase of salt-induction. Mutations abi1 and axr2, affecting ABA-perception in Arabidopsis, reduce the accumulation of both AtP5CS mRNAs during salt-stress, whereas ABA-signalling functions defined by the abi2 and abi3 mutations have no effect on salt-induction of the AtP5CS genes.
ChemInform Abstract: Acyclic Stereoselection. Part 35. Effect of Cation on Diastereofacial Selectivity in Aldol Reactions of a Chiral α‐Silyloxy Ketone. (1986)

Abstract Aus dem Keton (I) entstehen die Silylenolether (IV) und (V).
ChemInform Abstract: Reassignment of the Configuration of Several Ketocyclolignans Prepared from Podophyllotoxin. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impact energy absorption of shape memory alloy hybrid composite beams (1997)

A quasi-static model has been developed to calculate the impact force and the energy absorbed by a shape memory alloy/graphite/epoxy hybrid composite beam impacted at low velocity by a spherical nose steel projectile. The objective of this modeling effort is to further understand the energy absorption mechanisms involved in the low-velocity impact of SMA hybrid composite. This model has been developed based on the energy balance principle, and includes the local contact deformation, the global bending deformation, and the transverse shear deformation, as well as the martensitic phase transformation of the shape memory alloy fibers embedded in the hybrid composite beam. The Timoshenko beam solution is obtained in terms of Euler-Bernoulli solution, which provides an easy way to evaluate the effect of shear deformation on energy absorption. It is found that the impact energy absorption is increased due to the stress-induced martensitic phase transformation in shape memory alloy fibers, which goes in agreement with previous experimental work. It also shows that the transverse shear deformation and local contact deformation of the SMA hybrid composite beam are important parts of the energy absorption during a low-velocity impact. In conclusion, the developed model was able to shed some light on the impact energy absorption mechanisms cf SMA hybrid composites subjected to low-velocity impact.
Open-ended capstone project: designing and manufacturing of a low-cost carbon fiber reinforced composite suborbital rocket payload housing using a 3D printed core (2020)

Composite materials are utilized in many industries today due to its high performance and lightweight. However, the part manufacturing process of traditional composites is complicated and often involves high cost. The molds used for composite manufacturing are usually one of the contributors to the high part manufacturing cost. The authors demonstrated in this paper a manufacturing process for a carbon fiber reinforced composite rocket payload housing using an additively manufactured polylactic acid (PLA) payload housing core. The paper also demonstrates the designing and manufacturing of a functional product, which was used in a real-life application, achieved by college undergraduate students. The payload housing was designed to maximize space efficiency and the performance of the designed payload housing was simulated to verify that it met the structural requirements. Carbon fiber reinforced composites were wrapped and cured on the printed core using a wet layup technique. This process did not require traditional composite manufacturing molds, which resulted in significantly lower part manufacturing cost compared to a traditional composite part manufacturing processes using a mold. The carbon fiber-reinforced composite rocket payload housing was successfully built and mounted to a suborbital autonomous rocket and launched.
Carbohydrate - 25th international symposium. (2010)

The International Carbohydrate Symposium (ICS), held in Tokyo, included topics covering new developments in the field of glycoscience research. This conference report highlights selected presentations on glycoside hydrolase 1 (GH1) substrate specificity, antibody/lectin binding to oligosaccharides, probing the enzymatic properties of oligosaccharyltransferase, galactolipid biosynthesis, galactose disaccharide binding to a Pseudomonas lectin, O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins, and NMR J-coupling correlations in saccharides.
THE INFLUENCE OF IMPLEMENT TYPE, TILLAGE DEPTH, AND TILLAGE TIMING ON RESIDUE BURIAL (2002)

The ability of tillage implements to maintain surface residue coverage is largely dependent on the implementsmain active component. Two categories of tillage implements were compared to determine their ability to maintain grainsorghum (nonfragile) surface residue coverage when operating at two different tillage depths for fall and spring tillage.Chiseltype implements were found to bury substantially less crop residue than disktype implements. Disktype implementswere found to bury increased amounts of crop residue when operating at deeper tillage depths. Fall and spring tillage werealso found to leave equivalent amounts of percent residue cover and total mass of crop residue remaining on the soil surface.A more thorough understanding of the ability of tillage implements to maintain adequate amounts of surface residue coverageshould enable producers to select appropriate implements to maximize production while minimizing erosion.
The number of cell types, information content, and the evolution of complex multicellularity (2014)

The number of different cell types (NCT) characterizing an organism is often used to quantify organismic complexity. This method results in the tautology that more complex organisms have a larger number of different kinds of cells, and that organisms with more different kinds of cells are more complex. This circular reasoning can be avoided (and simultaneously tested) when NCT is plotted against different measures of organismic information content (e.g., genome or proteome size). This approach is illustrated by plotting the NCT of representative diatoms, green and brown algae, land plants, invertebrates, and vertebrates against data for genome size (number of base-pairs), proteome size (number of amino acids), and proteome functional versatility (number of intrinsically disordered protein domains or residues). Statistical analyses of these data indicate that increases in NCT fail to keep pace with increases in genome size, but exceed a one-to-one scaling relationship with increasing proteome size and with increasing numbers of intrinsically disordered protein residues. We interpret these trends to indicate that comparatively small increases in proteome (and not genome size) are associated with disproportionate increases in NCT, and that proteins with intrinsically disordered domains enhance cell type diversity and thus contribute to the evolution of complex multicellularity.
Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway (2017)

Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle. In ex vivo settings RBCs have been shown to release ATP in response to a number of stimuli, including stimulation of adrenergic receptors. Further evidence suggested that ATP release from RBCs was dependent on activation of adenylate cyclase (AC)/cyclic adenosine monophosphate (cAMP)-dependent pathways and involved the pannexin 1 (Panx1) channel. Here we show that RBCs express Panx1 and confirm its absence in Panx1 knockout (<sup>-/-</sup>) RBCs. However, Panx1<sup>-/-</sup> mice lack any decrease in exercise performance, challenging the assumptions that Panx1 plays an essential role in increased blood perfusion to exercising skeletal muscle and therefore in ATP release from RBCs. We therefore tested the role of Panx1 in ATP release from RBCs ex vivo in RBC suspensions. We found that stimulation with hypotonic potassium gluconate buffer resulted in a significant increase in ATP in the supernatant, but this was highly correlated with RBC lysis. Next, we treated RBCs with a stable cAMP analog, which did not induce ATP release from wild-type or Panx1<sup>-/-</sup> mice. Similarly, multiple pharmacological treatments activating AC in RBCs increased intracellular cAMP levels (as measured via mass spectrometry) but did not induce ATP release. The data presented here question the importance of Panx1 for exercise performance and dispute the general assumption that ATP release from RBCs via Panx1 is regulated via cAMP.
Attenuation of Sound in Water Containing Air Bubbles (1952)

Measurements of the attenuation of sound in water containing air bubbles were undertaken in order to confirm some aspects of a theory due to L. L. Foldy. Bubbles were produced by forcing compressed air through the cloth covering of several trays lying on the bottom of the Black Moshannon Lake. The distribution in size of the bubbles and the number of bubbles per unit volume were determined by photographing the bubbles and by collecting the volume of air which rose over a given area in a given time, the terminal velocity of rise being a known function of bubble diameter. The attenuation of sound was found to be very large at frequencies for which resonant bubbles were present, and much smaller at other frequencies, indicating that resonance absorption was the principal phenomenon observed. For the particular bubble distribution investigated, which contained 0.045 percent air by volume, the attenuation was found to be in satisfactory agreement with the theory and a maximum attenuation of approximately 20 db per inch was measured. Amplitude and phase fluctuations made it impossible to measure the phase velocity, but this quantity was computed from the bubble distribution.
Dynorphin‐phospholipid membrane interactions: Role of phospholipid head‐group and cholesterol (1996)

The interaction of the kappa-opioid receptor-selective heptadecapeptide dynorphin A(1-17) (Tyr1-Gly-Gly-Phe-Leu5-Arg-Arg-Ile-Arg-Pro10-Lys-Leu-Lys-Trp-As p15-Asn-Glu) with phospholipid membranes has been investigated by monitoring the leakage of the internal aqueous contents of liposomes, the changes in the tryptophan emission spectrum, and the collisional quenching of tryptophan fluorescence by brominated lipids. The peptide induces more extensive leakage of contents from phosphatidylserine than from phosphatidylcholine vesicles, and experiences a blue shift of the Trp fluorescence emission maximum in the presence of phosphatidylserine vesicles. In the presence of phosphatidylcholine vesicles, however, the Trp fluorescence intensity is reduced without a blue shift. In phosphatidylserine membranes containing 10 mol% phosphatidylcholine, the intensity of the blue-shifted fluorescence is enhanced. This avid interaction of dynorphin A(1-17) with phosphatidylserine membranes is likely to be mediated by the positively charged Arg and Lys groups. It is proposed that, while the N-terminus of the peptide may be embedded in the bilayer in analogy with dynorphin (1-13), the C-terminal region of dynorphin A (1-17) bends back onto the bilayer/water interphase, and that the Trp14 residue is stabilized in a hydrophobic pocked near the interphase by the interaction of the neighboring charged amino acids with the phosphate, carboxyl and amino groups on phosphatidylserine.
The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation (2011)

SOX11 is a functionally associated protein in EOC with prognostic value for high-grade tumours. Re-expression of SOX11 in EOC indicates a potential use of epigenetic drugs to affect cellular growth in SOX11-negative tumours.
New Frontiers in Earth Science and Imaging Radar Technologies (1997)

The development of the multi-freqwuency, polarimetric SIR-C/X-SAR insturmetns on two Space Shuttle missions in April and October 1994 represents a milestone in the history of imaging radars. The advancement of knowledge in the field of microwave remote sensing accomplished as well as the verification of earlier findings since the two successful Sir-C/X-sAR missions is tremendeous. Results clearly show the increased value of using multiparameter and interferometric capabilities to charcterize the Earth's surface and vegetation cover and to generate geophysical porducts compared with optical sensors or single-channel radar alone.
Leukocyte expression profiles reveal gene sets with prognostic value for seizure-free outcome following stereotactic laser amygdalohippocampotomy (2019)

Among patients with intractable epilepsy, the most commonly performed surgical procedure is craniotomy for amygdalohippocampectomy (AH). Stereotactic laser amygdalohippocampotomy (SLAH) has also been recently employed as a minimally invasive treatment for intractable temporal lobe epilepsy (TLE). Among patients treated with AH and SLAH approximately 65% and 54% of patients become seizure-free, respectively. Therefore, selection criteria for surgical candidates with improved prognostic value for post-operative seizure-free outcome are greatly needed. In this study, we perform RNA sequencing (RNA-Seq) on whole blood leukocyte samples taken from 16 patients with intractable TLE prior to SLAH to test the hypothesis that pre-operative leukocyte RNA expression profiles are prognostic for post-operative seizure outcome. Multidimensional scaling analysis of the RNA expression data indicated separate clustering of patients with seizure free (SF) and non-seizure-free (NSF) outcomes. Differential expression (DE) analysis performed on SF versus NSF groups revealed 24 significantly differentially expressed genes (≥2.0-fold change, p-value < 0.05, FDR <0.05). Network and pathway analyses identified differential activation of pathways involved in lipid metabolism, morphology of oligodendrocytes, inflammatory response, and development of astrocytes. These results suggest that pre-operative leukocyte expression profiles have prognostic value for seizure outcome following SLAH.
A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced   adrenoceptor density (1993)

These data indicate that protein kinase C modifies both the catalytic subunit of adenylyl cyclase and the guanine nucleotide stimulatory protein (Gs), and also suggest that NaF and GppNHp act at different sites on Gs alpha. PMA enhances adenylyl cyclase responsiveness despite loss of beta adrenoceptors in cultured neonatal rat ventricular myocytes. These findings suggest that Ca2+ and phospholipid dependent protein kinase C acting at multiple sites in the beta adrenoceptor-adenylyl cyclase cascade may be involved in the regulation of cAMP concentrations in myocardial cells.