gebhart/patrepeval huggingface dataset:
Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia (2000)

The molecular basis accounting for the peculiar clinical and biological features of hairy cell leukaemia (HCL) is currently unknown. Deregulation of cell cycle genes plays a significant role in oncogenesis and there is considerable evidence suggesting that Cdk inhibitors (Ckis) function as tumour suppressors. We and others have recently demonstrated low expression of Cki p27 in very aggressive neoplasms and high‐grade lymphomas. To investigate whether HCL cases express normal p27 protein, as in other low‐grade lymphomas with a low proliferation index, 58 cases of HCL were characterized using a sensitive biotin‐streptavidin‐immunoperoxidase technique and specific antibodies against p27. All HCL cases showed either no or very weak reactivity, in contrast to other types of low‐grade B‐cell lymphoma [22 cases of chronic lymphocytic leukaemia (CLL), 12 cases of gastric marginal B‐cell lymphoma (MALT), 16 cases of follicular lymphomas and two cases of splenic marginal zone lymphomas]. To investigate the possible mechanism(s) accounting for the low p27 expression observed in hairy cells, multiple approaches were used. According to these molecular studies, low levels of p27 are not as a result of (1) increased ubiquitin‐mediated degradation, (2) decreased levels of p27 transcription or (3) p27 somatic mutations and/or allelic loss. These findings suggest that low p27 protein expression in HCL may be achieved through post‐transcriptional regulation. Finally, our data demonstrate that p27 expression in HCL does not correlate with either cell cycle progression or proliferation index, suggesting that low levels of p27 in hairy cells may be associated with their unique stage of B‐cell differentiation and/or the activation of as yet unknown pathways.
A THEORETICAL DISCUSSION OF A K-BAND MICROWAVE CAVITY-RESONATOR SPECTROMETER. (1969)

We present an adult autopsy case of primary hyperoxaluria type 1. Diagnosis was established with skin biopsy and subsequent genetic analysis one month prior to death. At autopsy, calcium oxalate crystals refringent to polarized light were found systemically. Interestingly, however, calcium oxalate crystals were not identified in the bone. Additionally, we have included a review of the literature for previous autopsy cases, presentations, diagnosis, complications, and treatment of this rare genetic systemic process.
Hearing ability decreases in aging locusts (2015)

Insects display signs of ageing, despite their short lifespan. However, the limited studies on senescence emphasize longevity or reproduction. We focused on the hearing ability of ageing adult locusts, Schistocerca gregaria. Our results indicate that the youngest adults (2 weeks post-maturity) have a greater overall neurophysiological response to sound, especially for low frequencies (<10 kHz), as well as a shorter latency to this neural response. Interestingly, when measuring displacement of the tympanal membrane that the receptor neurons directly attach to, we found movement is not directly correlated with neural response. Therefore, we suggest the enhanced response in younger animals is due to the condition of their tissues (e.g. elasticity). Secondly, we found the sexes do not have the same responses, particularly at 4 weeks post-adult moult. We propose female reproductive condition reduces their ability to receive sounds. Overall our results indicate older animals, especially females, are less sensitive to sounds.
Using Low-frequency Oscillation to Detect Bronchodilator Responsiveness in Infants (1998)

The potential of the low-frequency forced oscillation technique (FOT) to measure the response to inhaled salbutamol was studied in 13 infants with a history of recurrent wheeze and nine healthy infants. The input impedance of the respiratory system (Zrs) between 0.5 and 20 Hz was measured at a transrespiratory pressure of 20 cm H2O during a brief Hering-Breuer reflex-induced pause in breathing. Parameters representing the airway resistance (Raw) and inertance (law), and a constant-phase tissue damping (G) and elastance (H) were estimated from the Zrs spectra. Lung function was measured before and after the administration of 500 microg of salbutamol via a small-volume metal spacer. Six of these infants also received a placebo aerosol. A fall in Raw (13% for the entire group) occurred following treatment with salbutamol (p < 0.008) but not placebo. There was no significant difference in the response to salbutamol between the normal infants (7.65% +/- 5.49%) and those with recurrent wheeze (17.58% +/- 8.67%). On grouped data, the fall in G just failed to reach statistical significance (p = 0.05) after correcting the significance level for multiple tests. No significant change occurred in law or H. We conclude that the low-frequency FOT is a suitable methodology for studying bronchodilator responsiveness in infants.
Flexible Operation of Fixed‐Bed Reactors for a Catalytic Fuel Synthesis—CO<sub>2</sub> Hydrogenation as Example Reaction (2015)

Abstract It may become attractive in the future to operate fuel‐related chemical reactions, with H 2 as reactant, under flexible load conditions when H 2 is produced through H 2 O electrolysis using fluctuating renewable energy. In this way, the size of the H 2 storage device connected to the electrolysis cell can be reduced and, consequently, its investment costs. The design of a flexible reactor depends on the characteristics of the catalyst and the chemical reaction. CO 2 hydrogenation over Fe catalysts to short‐chain hydrocarbons, which can be used to adjust the heating value of substitute natural gas, is investigated as example reaction. A specific reactor design for flexible operation with gas recycling is a consequence of the constraints resulting from product partial pressures and reaction temperature. The experimental and mathematical methods developed can be applied to other fuel‐synthesis processes.
Feasibility study of a single-use balloon-assisted robotic colonoscope in healthy volunteers (2021)

<b>Background and study aims </b> Despite its widespread adoption, colonoscope still has its limitations. Advancement is often limited by the looping of colon. The isolation of SARS-CoV-2 in stool raises concern for the risk of disease transmission. A single-use robotic colonoscope, the NISInspire-C System, that features a balloon-suction anchorage mechanism was developed to address these. <b>Methods </b> The NISInspire-C balloons are designed to provide anchorage for straightening of the colon during advancement. Angulation at the bending section is tendon-wire driven by servo mechanisms integrated into a robotic control console. This was a pilot, prospective trial to evaluate the safety and feasibility of this system. Healthy volunteers underwent examination with the NISInspire-C, followed by the conventional colonoscope. The procedure time, cecal intubation rates (CIR), complications, and level of pain were measured. <b>Results </b> A total of 19 subjects underwent the examination. The cecal intubation rate was 89.5 % (17/19) and the overall time-to-cecum was 26.3 minutes (SD: 17.9 mins). There were no procedure-related complications. Polyps were detected in seven of 19 (36.8 %) subjects during the NISInspire-C procedure. Three more subjects were found to have adenomatous polyps with the conventional colonoscope. There was minimal variation in level of pain during the procedures with the two colonoscopes. <b>Conclusion </b> The single-use robotic colonoscope NISInspire-C is a safe and feasible alternative to the conventional colonoscope. Further technical refinement is needed to improve the CIR. This study was limited by its small sample size.
Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues <i>In Vivo</i> (2019)

p53 protein, activated and stabilized by posttranslational modifications, performs its major functions by inducing DNA repair, cell-cycle arrest, or apoptosis through transcriptional activation. Here, we determined the ability of p53 protein stabilized via proteasome inhibition to perform similar functions as p53 induced by stresses such as DNA damage. Treating mice with the proteasome inhibitor bortezomib stabilized p53 in stem/progenitor cells of the intestine and stomach, in other proliferating tissues, and in intestinal tumors. Robust basal <i>p53</i> mRNA levels were observed in the same compartments where p53 was stabilized. Spatial activation of p53 target genes in response to bortezomib in the small intestine demonstrated that <i>CDKN1A</i> and <i>BAX</i> were upregulated in the proliferative crypts but not in the differentiated villi of the small intestine; <i>PUMA</i> was specifically activated at the crypt base of p53 wild-type mice. Thus, cellular context determines the p53 transcriptional target selection. p53-dependent apoptosis was induced in Lgr5-expressing stem cells of the small intestine and high p53 transcriptional activity and apoptosis was induced in intestinal adenomas and in xenograft tumors. Bortezomib inhibited the growth of intestinal adenomas and xenograft tumors with wild-type p53, indicating the importance of p53 in the response to proteasome inhibitors in tissue homeostasis and in cancer therapy. SIGNIFICANCE: These findings show that bortezomib is less active in p53-defective tumors, yet its success in treating multiple myeloma suggests its use can be extended to p53-proficient solid tumors.
The 3a Protein from Cucumber Mosaic Virus Increases the Gating Capacity of Plasmodesmata in Transgenic Tobacco Plants (1994)

The 3a protein, encoded by RNA 3 of cucumber mosaic virus (CMV), is the putative movement protein of viral progeny in infected plants. An analysis of transgenic tobacco plants constitutively expressing the CMV 3a protein showed that the protein is accumulated in leaves at every stage of development. In fully expanded leaves the protein is immunodetectable mostly in a cell-wall- enriched fraction. Dye-coupling experiments using fluor- escent-dextran probes were performed on fully expanded leaves to study the modifying effect of CMV 3a protein on the gating capacity of plasmodesmata. Movement of fluorescein-isothiocyanate-labelled dex- tran with a mean molecular mass of 10000 Da, and an approximate Stokes’ radius of 2·3 nm, was detected between cells of the 3a protein transgenic plants, but not in the control plants. These results are consistent with the idea that the CMV 3 a protein is involved in the modification of plasmodesmata and, therefore, in the cell-to-cell spread of the virus.
Thermoelectric Properties of La-Doped BaSi<SUB>2</SUB> (2008)

The authors tried to enhance the thermoelectric figure of merit of BaSi2 by doping La. Polycrystalline samples of La-doped BaSi2: Ba1−xLaxSi2 (0≤x≤0.08) were prepared and characterized. The effect of La-doping was investigated by measuring the thermoelectric properties above room temperature to 973 K. La could dissolve in BaSi2 up to around x=0.03, while LaSi2 appeared as the second phase in the higher x range. Both the electrical resistivity and thermal conductivity of the La-doped samples were lower than those of the non-doped BaSi2. Ba1−xLaxSi2 (x=0.02) indicated the largest power factor and dimensionless figure of merit (ZT). The ZT value was 0.07 at 970 K, which was approximately 7 times larger than that of non-doped BaSi2.
Compaction trends for shale and clean sandstone in shallow sediments, Gulf of Mexico (2009)

Compaction depth trends are important in drilling, basin modeling, and seismic exploration for several purposes: (1) to de-tect overpressure and hydrocarbon zones and distinguish them from seismic velocity anomalies; (2) to calculate interval velocities and depth conversion involving seismic data and Earth models; (3) to predict seismic signatures of sand-shale interfaces as a function of depth; and (4) to recognize over-compacted zones due to uplift. Several authors have studied the effects of compaction on the porosity of sands and shales (e.g., Magara, 1980; Ramm and Bjorlykke, 1994). The effects of compaction on velocity-depth trends have been provided by different authors (e.g., Al-Chalabi, 1997; Faust, 1951; Japsen, 2000). However, porosity and velocity depth trends in the shallow section are not well established. The main challenge in computing such trends is the paucity of well-log data in the shallow subsurface. Figure 1, a typical well log from the Gulf of Mexico, lacks measurements in the shallow section (&lt; 3000 ft or ∼1000 m) due to riser-less drilling, and the log response from the deeper section cannot be used to compute the normal compaction trend due to overpressure. One way to overcome this challenge is to integrate data from multiple sources. In this paper, we compute porosity and velocity depth trends by integrating data from multiple sources including well logs, geotechnical borehole data, and core measurements from shallow sections of the Gulf of Mexico, and laboratory measurements at low effective pressure.
Extensions to CT-KIP to support one- and two-pass key initialization (2006)

This document describes extensions to the Cryptographic Token Key
Initialization Protocol (CT-KIP) to support one-pass (i.e. one
message) and two-pass (i.e. one round-trip) cryptographic token key
initialization.
Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy (2014)

This study revealed that NXG is characterized by impaired macrophage lipid homeostasis associated with a systemic inflammatory profile that may result from the interaction of MIg and lipoproteins.
Mechanistic Considerations in the Plasma Deposition of Silicon Nitride Films (1990)

A stainless steel screen placed directly over the substrate in an RF glow discharge significantly altered plasma deposited (PD) silicon nitride film chemical composition and structure as measured by x‐ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy. Changes in film composition were more pronounced for PD silicon nitride films formed using as the nitrogen source gas rather than . An increase in the N:Si ratio was observed for all films deposited using the screen. This change in N:Si ratio was also reflected in an increased N‒H and decreased Si‒H bonding structure. These results are similar to those obtained previously in triode and remote plasma reactors, thereby suggesting common deposition mechanisms for films deposited in different reactor configurations.
Ditopic binding by a self-assembled receptor: Metal in a structural and functional role (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDitopic binding by a self-assembled receptor: Metal in a structural and functional roleJinho Lee and Alan W. SchwabacherCite this: J. Am. Chem. Soc. 1994, 116, 18, 8382–8383Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ja00097a062https://doi.org/10.1021/ja00097a062research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
688. Pseudotyping FIV-Based Lentiviral Vectors with Baculovirus GP64 Confers Apical Entry into Airway Epithelia (2004)

Top of pageAbstract
The use of gene transfer to treat or prevent cystic fibrosis lung disease has been limited in part by the inability of vectors to efficiently transduce airway epithelia from the apical surface. Using a feline immunodeficiency virus (FIV)-based lentiviral vector system, we recently observed that the envelope glycoprotein GP64 from baculovirus Autographa californica nucleopolyhedrovirus (AcMNPV) confers apical entry into polarized primary cultures of human airway epithelia. High titer FIV-vector (>10e9 TU/ml) was achieved by pseudotyping with baculovirus GP64 (GP64-FIV) and these titers meet or exceed those obtained with the VSV-G envelope. We tested fusion (F) proteins from four other baculoviruses for their ability to pseudotype FIV, and obtained very low titers (less than or equal to 10e2). Interestingly, AcMNPV GP64 shares sequence identity with influenza D envelope GPs such as Thogotovirus. Pseudotyping FIV with Thogoto GP resulted in titers of ~10e6 TU/ml and also conferred apical entry into polarized human airway epithelial cell cultures. These data lend support to the notion of horizontal transfer of GPs during the evolution of AcMNPV and Influenza D viruses. The receptor for GP64 is currently unknown; however, we investigated the entry of GP64-FIV into epithelia. Pretreating A549 cells with the ionophores monensin or NH4Cl significantly decreased the transduction by GP64-FIV as measured by beta-Galactosidase expression. These data suggest that similar to VSV-G, GP64-FIV transduction requires a low pH endosome pathway. These findings identify a pseudotyped, integrating viral vector with the capacity to infect from the apical surface for the convenient delivery of transgenes to airway epithelia.
Multi-Kernel Capsule Network for Schizophrenia Identification (2019)

Objective: Schizophrenia seriously affects the quality of life. To date, both simple (linear discriminant analysis) and complex (deep neural network) machine learning methods have been utilized to identify schizophrenia based on functional connectivity features. The existing simple methods need two separate steps (i.e., feature extraction and classification) to achieve the identification, which disables simultaneous tuning for the best feature extraction and classifier training. The complex methods integrate two steps and can be simultaneously tuned to achieve optimal performance, but these methods require a much larger amount of data for model training. Methods: To overcome the aforementioned drawbacks, we proposed a multi-kernel capsule network (MKCapsnet), which was developed by considering the brain anatomical structure. Kernels were set to match with partition sizes of brain anatomical structure in order to capture interregional connectivities at the varying scales. With the inspiration of widely-used dropout strategy in deep learning, we developed vector dropout in the capsule layer to prevent overfitting of the model. Results: The comparison results showed that the proposed method outperformed the state-of-the-art methods. Besides, we compared performances using different parameters and illustrated the routing process to reveal characteristics of the proposed method. Conclusion: MKCapsnet is promising for schizophrenia identification. Significance: Our study not only proposed a multi-kernel capsule network but also provided useful information in the parameter setting, which is informative for further studies using a capsule network for neurophysiological signal classification.
Phenomenology of Rayleigh-Taylor Turbulence (2003)

I analyze the advanced mixing regime of the Rayleigh-Taylor incompressible turbulence in the small Atwood number Boussinesq approximation. The prime focus of my phenomenological approach is to resolve the temporal behavior and the small-scale spatial correlations of velocity and temperature fields inside the mixing zone, which grows as proportional, variant t(2). I show that the "5/3"-Kolmogorov scenario for velocity and temperature spectra is realized in three spatial dimensions with the viscous and dissipative scales decreasing in time, proportional, variant t(-1/4). The Bolgiano-Obukhov scenario is shown to be valid in two dimensions with the viscous and dissipative scales growing, proportional, variant t(1/8).
Probabilistic global maps of the CO<sub>2</sub> column at daily and monthly scales from sparse satellite measurements (2017)

Abstract The column‐average dry air‐mole fraction of carbon dioxide in the atmosphere (XCO 2 ) is measured by scattered satellite measurements like those from the Orbiting Carbon Observatory (OCO‐2). We show that global continuous maps of XCO 2 (corresponding to level 3 of the satellite data) at daily or coarser temporal resolution can be inferred from these data with a Kalman filter built on a model of persistence. Our application of this approach on 2 years of OCO‐2 retrievals indicates that the filter provides better information than a climatology of XCO 2 at both daily and monthly scales. Provided that the assigned observation uncertainty statistics are tuned in each grid cell of the XCO 2 maps from an objective method (based on consistency diagnostics), the errors predicted by the filter at daily and monthly scales represent the true error statistics reasonably well, except for a bias in the high latitudes of the winter hemisphere and a lack of resolution (i.e., a too small discrimination skill) of the predicted error standard deviations. Due to the sparse satellite sampling, the broad‐scale patterns of XCO 2 described by the filter seem to lag behind the real signals by a few weeks. Finally, the filter offers interesting insights into the quality of the retrievals, both in terms of random and systematic errors.
FFT speed multiuser detection for high rate data mode in UTRA-FDD (2002)

The family of international standards for mobile communications IMT-2000 includes amongst others the Universal Terrestrial Radio Access (UTRA) proposal, which consists of two modes: frequency division duplex (FDD) and time division duplex (TDD). Both are in principle wideband CDMA (W-CDMA) systems. Conventional detectors like the RAKE receiver do not decrease the multiple access interference (MAI). For a further improvement of system capacity multiuser detectors (MUD) should be applied. But the computational effort for such algorithms is high. In this paper a new approach based on linear MUD with FFT speed (Vollmer et al. 1999) is investigated for the high rate data transfer mode in UTRA-FDD.
A RETROSPECTIVE STUDY OF 27 DOGS WITH INTRANASAL NEOPLASMS TREATED WITH COBALT RADIATION (1991)

Twenty‐seven dogs with sinonasal neoplasms were treated with cobalt radiation. Cytoreductive surgery was performed in six of the patients prior to initiation of irradiation. Dogs received from 4,180 to 5,400 cGy on a Monday/Wednesday/Friday schedule given in 10 to 12 fractions over a four week period. All dogs had a computed tomography (CT) based, computer generated radiation treatment plan. Survival time ranged from 2.5 to 46.0 months with a mean and median of 20.7 ± 3.3 and 12.8 months, respectively. The one‐ and two‐year survival rates were 59% and 22%. Survival time compares favorably to those reported previously for dogs treated with cytoreductive surgery and orthovoltage x‐rays. Survival time is longer than that reported previously using megavoltage radiation alone or in conjunction with surgery. It is likely that the improved survival reported herein is, at least in part, related to the use of computed tomography for tumor localization and computer generation of the treatment plan. No prognostic variables were identified in the present study. Survival time was not significantly different between dogs with carcinoma versus sarcoma. There was no significant difference between patients that had undergone cytoreductive surgery prior to radiotherapy, and those patients treated with radiotherapy alone.