gebhart/patrepeval huggingface dataset:
Abnormal Features in Skeletal Muscle from Mice Lacking Mitsugumin29 (1999)

Physiological roles of the members of the synaptophysin family, carrying four transmembrane segments and being basically distributed on intracellular membranes including synaptic vesicles, have not been established yet. Recently, mitsugumin29 (MG29) was identified as a novel member of the synaptophysin family from skeletal muscle. MG29 is expressed in the junctional membrane complex between the cell surface transverse (T) tubule and the sarcoplasmic reticulum (SR), called the triad junction, where the depolarization signal is converted to Ca(2+) release from the SR. In this study, we examined biological functions of MG29 by generating knockout mice. The MG29-deficient mice exhibited normal health and reproduction but were slightly reduced in body weight. Ultrastructural abnormalities of the membranes around the triad junction were detected in skeletal muscle from the mutant mice, i.e., swollen T tubules, irregular SR structures, and partial misformation of triad junctions. In the mutant muscle, apparently normal tetanus tension was observed, whereas twitch tension was significantly reduced. Moreover, the mutant muscle showed faster decrease of twitch tension under Ca(2+)-free conditions. The morphological and functional abnormalities of the mutant muscle seem to be related to each other and indicate that MG29 is essential for both refinement of the membrane structures and effective excitation-contraction coupling in the skeletal muscle triad junction. Our results further imply a role of MG29 as a synaptophysin family member in the accurate formation of junctional complexes between the cell surface and intracellular membranes.
Co‐inhibitory roles for glucocorticoid‐induced TNF receptor in CD1d‐dependent natural killer T cells (2008)

Invariant natural killer T (iNKT) cells are a special subset of alphabeta T cells with invariant TCR, which recognize alpha-galactosylceramide (alpha-GalCer) presented by CD1d. In addition to signals through the invariant TCR upon stimulation with alpha-GalCer, costimulatory signals, such as signals through CD28 and OX40, are indispensable for full activation of iNKT cells. In this study, we investigated the functions of a well-known costimulatory molecule, glucocorticoid-induced TNF receptor (GITR), on Ag-induced iNKT cell activation. Unexpectedly, engagement of GITR by agonistic mAb DTA-1 suppressed proliferation and cytokine production of iNKT cells upon alpha-GalCer stimulation. In addition, GITR signals in iNKT cells during only the Ag-priming phase was sufficient to inhibit the iNKT cell activation. Consistent with these results, the GITR-deficient iNKT cells showed enhanced proliferation and increased cytokine production upon alpha-GalCer stimulation both in vitro and in vivo. Furthermore, the in vivo administration of alpha-GalCer suppressed tumor metastasis more efficiently in GITR-deficient mice than in wild-type mice. Collectively, GITR plays a co-inhibitory role in Ag-induced iNKT cell activation.
Whole Body-MRI imaging with a continuously moving table platform in detection of metastatic disease in cancer patients First Results of a feasibility study (2003)

The purpose of this study was to evaluate a new protocol for axial Whole Body-MRI imaging performed with a continuously moving table platform in comparison to Whole Body-MRI using a multi-station coronal Turbo-STIR as a staging and screening method in cancer patients.The first results of our study demonstrated that Whole Body-MRI as a fast and accurate examination in cancer patients in nearly 10 minutes is feasible and comparable to Whole Body-MRI using a turbo-STIR-sequence combined with a rolling table platform. Whole Body-MRI imaging may compete with the established imaging technique like skeletal scintigraphy and FDG-PET in cancer patients.
Evaluation of Coal Liquids in a Single Cylinder Direct-Injection, Stratified-Charge Engine (1981)

<div class="section abstract"><div class="htmlview paragraph">ABSTRACT</div><div class="htmlview paragraph">Indicated specific energy consumption and exhaust emissions were measured for three coal-derived liquids in a direct injection, stratified-charge (PROCO) engine. The three fuels were obtained from different coal refining processes. One of the fuels met current gasoline specifications while the other two had volatilities somewhat below the specification and were more typical of some current gasoline blending components.</div><div class="htmlview paragraph">A comparison of test results from these fuels was made with Indolene Clear, a petroleum-derived reference fuel. Little difference in indicated specific energy consumption or NO<sub>X</sub> emissions was observed between the coal liquids and Indolene Clear. The two fuels which had low front end volatility showed higher hydrocarbon and CO emissions at low speeds and loads than the reference fuel but performed well overall.</div><div class="htmlview paragraph">On the basis of the tests, all three fuels appear to be potentially satisfactory in a direct-injection, stratified-charge engine. No characteristics attributable to their coal origin caused any significant problems in operation in such an engine.</div></div>
ChemInform Abstract: PYRAZOLO(1,5‐F)PHENANTHRIDINE AND DERIVATIVES, ELECTROCHEMICAL AND PHOTOCHEMICAL SYNTHESIS (1975)

Abstract Die aus den Carbonylverbindungen (I) über die Pyrazoline (II) erhältlichen Pyrazole (III) lassen sich sowohl elektro‐ als auch photochemisch zu den Pyrazolophenanthridinen (IV) cyclisieren.
Mechanical Measurements of the Melting Transition in Thin Liquid-Crystal Films (1982)

Shear mechanical properties of the liquid crystal 4-$n$-pentylbenzenethio-4\ensuremath{'}-$n$-tetradecyloxybenzoate ($\stackrel{-}{14}\mathrm{S}5$) have been studied in films as thin as two molecular layers. Crystalline two-layer films were found to melt directly into a liquid phase by a large first-order transition. Crystalline films of three or more layers melted in two stages both by first-order transitions. Mechanical properties of the intermediate phase indicated crystalline surface layers with an anomalously soft response for a three-layer film.
Exhibits (1886)

The Colcasia and the Laportea both occur plentifully in the
Study on Pretreatment of Leachate from Refuse Storage Pit in Municipal Solid Waste Incinerator by Vacuum Evaporation (2006)

Leachate from refuse storage pit(LRSP) of a municipal solid waste incinerator(MSWI) located in Shanghai was treated by vacuum evaporation process.The variation characteristics of the condensate components in the evaporation process of the leachate were analyzed.The results showed that the LRSP has high mass concentration of volatile organic matters,mainly composed of low molecular weight alcohols and volatile fat acids(VFA) with the formula number of the carbon less than seven,which account for about 50% organic carbon in the LRSP.84% of LRSP and 21% organic matter of the original LRSP could be transferred into the condensate,where no ammonia was detected.More than 90% of the organic matters in the condensate were composed of VFA and alcohols.The residual liquid,whose mass concentration of organic matters was 4.4 times of the original LRSP,could be further disposed by incineration.It was easier to treat the products from LRSP evaporation than that of the original LRSP.The recovered energy from the MSWI could be utilized for the evaporation process,which can reduce the cost of evaluation treatment.
Estimation of Total Body Fat from Roentgenograms (1958)

Pretreatment with two doses of reserpine (each 0.1 mg/kg, intraperitoneally) sensitizes the heart to the positive chronotropic action of norepinephrine and reduces the response to stimulation of the accelerans nerve. Ganglionic transmission remains unaffected. The results indicate that the presence of certain stores of peripheral sympathetic transmitter is essential for the production of tachycardia by stimulation of the accelerans nerve.
Novel Electron Donor Acceptor Nanocomposites (2010)

This chapter contains sections titled: Introduction Electron Donor-Fullerene Composites Carbon Nanotubes Other Nanocarbon Composites References
Copy Number Variation Analysis of Matched Ovarian Primary Tumors and Peritoneal Metastasis (2011)

Ovarian cancer is the most deadly gynecological cancer. The high rate of mortality is due to the large tumor burden with extensive metastatic lesion of the abdominal cavity. Despite initial chemosensitivity and improved surgical procedures, abdominal recurrence remains an issue and results in patients' poor prognosis. Transcriptomic and genetic studies have revealed significant genome pathologies in the primary tumors and yielded important information regarding carcinogenesis. There are, however, few studies on genetic alterations and their consequences in peritoneal metastatic tumors when compared to their matched ovarian primary tumors. We used high-density SNP arrays to investigate copy number variations in matched primary and metastatic ovarian cancer from 9 patients. Here we show that copy number variations acquired by ovarian tumors are significantly different between matched primary and metastatic tumors and these are likely due to different functional requirements. We show that these copy number variations clearly differentially affect specific pathways including the JAK/STAT and cytokine signaling pathways. While many have shown complex involvement of cytokines in the ovarian cancer environment we provide evidence that ovarian tumors have specific copy number variation differences in many of these genes.
Tuning the Stacking Properties of <i>C</i><sub>3</sub>‐Symmetrical Molecules by Modifying a Dipeptide Motif (2007)

C3-symmetrical molecules are described which consists of a 1,3,5-benzenetricarboxamide core extended with dipeptide fragments bearing peripheral mesogenic groups. Small structural modifications in the dipeptide fragment have been performed to demonstrate their influence on the stability of the stacks and on the order within the self-assemblies formed. Seven C3-symmetrical discs have been investigated, all with different combinations of glycine, L- and/or D-phenylalanine in the dipeptide fragments. Characterization of these discotics in the neat state using differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarized optical microscopy (POM) and in solution with circular dichroism (CD), UV-visible spectroscopy, low-concentration proton nuclear magnetic resonance and IR spectroscopy reveals that there is a clear trend in the stack stability, going from the glycine-phenylalanine motifs to the phenylalanine-phenylalanine ones. The combination of a larger hydrophobic core, more confinement of space and the possibility of additional pi-pi interactions leads to more stable stacks. Surprisingly, the weakest stacks consist of discotics of which the center is extended with L-phenylalanyl-glycines and not of discotics of which the center is extended with the glycyl-L-phenylalanine sequences. Furthermore, the XRD investigations show that it is difficult to form well-ordered self-assemblies in the neat state. And, CD measurements point out that some of the discs have a very complex energy landscape in solution. These observations suggest that small differences in the balance between the secondary interactions originating from the benzenetricarboxamide core and the dipeptide fragments, have a strong influence on the order within the stack. From these results it can be concluded that subtle modifications in the peptide fragments of the discs cause significant changes in the stacking properties, stressing the importance of understanding the self-assembly mechanism of each discotic in order to clarify its self-assembly behavior.
Logic Programming with Requests (1999)

We propose an extension of logic programming where the user can specify, together with the initial query, the information he is interested in by means of a request. This allows one to extract a result from an incomplete computation, such as the prefix of an infinite derivation. The classical property of independence of the selection rule doesn&apos;t hold anymore. It is shown that under mild conditions a class of selection rules can be identified for which independence holds. A model-theoretic semantics for the language is given. 1 Introduction The purpose of this paper is to present an extension of logic programming where it is possible to express a form of partial result. This is done by considering instead of the traditional successful derivations, where all subgoals are resolved, so-called adequate derivations, where possibly some subgoals remain. The intuition is that an adequate derivation is similar to a derivation in a lazy functional language, like for instance Haskell, where an e...
Soft magnetic properties of Permalloy multilayered films with ceramic intermediate layers (1995)

Multilayer thin films of Permalloy with SiO/sub 2/, Si/sub 3/N/sub 4/, Al/sub 2/O/sub 3/, or AlN as a ceramic intermediate layer were prepared by rf magnetron sputtering. The effects of intermediate layer materials on the soft magnetic properties, internal stress, and microstructure of multilayer thin films with various Permalloy thickness were investigated. Effective permeability /spl mu//sub eff/, coercive force H/sub c/, and internal stress /spl sigma/ of multilayers with a fixed intermediate layer (20 /spl Aring/), and a thickness of the permalloy layer, varying from 200 to 5000 /spl Aring/ (number of magnetic layers from 50 down to 2) were measured. Multilayered structures with ceramic intermediate layer thickness of 20 /spl Aring/ and Permalloy layer thickness of less than 500 /spl Aring/ had the lowest coercive force and the highest effective permeability.
Essential oil content and composition of German Chamomile affected by age of seedling and date of sowing (2007)

German chamomile (Matricaria chamomilla) is an annual plant belonging to Asteraceae family. Since chamomile is cultivated commercially, the optimum time for sowing has been the subject of a number of studies [1, 2, 3]. The aim of the present investigation was to determine the influence of sowing time and age of seedling on the essential oil content and composition of German chamomile grown in Belgium. The experiment was carried out on a loamy sand soil at Ghent University, Belgium, during 2005. The treatments consisted of 4 different times of planting (15 April, 1, 15 and 30 May) in combination with 5 seedling ages (30, 45, 60, 75 and 90 days) replicated thrice in a randomized complete block design. Seedlings were transplanted at a spacing of 10cm x 10cm. Plot size under the trial was 70×50cm2. After drying the flowers, the essential oil was isolated by Likens-Nickerson extraction followed by GC-MS analysis.The results indicate that for the first date of sowing, the measured traits were not significantly influenced by the age of seedling at transplanting except for the spathulenol content whereby the highest amount was obtained for 90 days-old seedlings. The planting time for 30 days seedlings had significant effects on the content of (E)-β-farnesene, bisabolol oxide (A), bisabolon oxide and spathulenol.
Current Distribution in a Parallel‐Plate Reactor: A Comparison of Steady and Sinusoidal Cell‐Voltage Control (1991)

A time‐varying electrodeposition in a parallel‐plate reactor is modeled to study the effect of sinusoidal cell‐voltage control on the uniformity of the cathodic current distribution. An analytic expression for the electrolyte potential was coupled through Butler‐Volmer kinetics, for the same metal reaction at the anode and cathode, to a finite‐element solution of the transient convective‐diffusion equation. The latter included both streamwise and transverse diffusion terms, with well‐developed laminar flow assumed to be occurring in the reactor. At low Peclet number, streamwise diffusion significantly increases the current in comparison to that in its absence and effects a more symmetric current distribution. With increasing Peclet number at a constant cell voltage, the current may pass through a minimum, and the deposit nonuniformity through a maximum, with both effects resulting from the decoupling of cathode and anode diffusion boundary layers. Deposit nonuniformity increases with the ratio of the interelectrode distance to electrode length for both periodic and steady control. The uniformity of the deposit increases with frequency at a given bias and amplitude of a sinusoidal cell‐voltage oscillation. At cycle‐averaged currents which are a large fraction of the mass‐transfer limiting current, sinusoidal cell‐voltage control can result in a more uniform deposit than steady control, for select values of the control waveform. However, at a low value of the dimensionless exchange current density and a small fraction of the limiting current, sinusoidal voltage control causes a more nonuniform deposit than steady control.
A SIMPLE METHOD FOR ANTERIOR SEGMENT PHOTOGRAPHY OF THE EYE WITH STANDARD EQUIPMENT (1978)

A simple hand-held system for colour photography of the anterior eye structures using a standard camera and conventional incandescent slit lamp is presented for use by a general eye practitioner. No electronic flash is required. The anterior ocular pathology is well documented with the method.
Microsearch: An Interface for Semantic Search (2008)

Abstract. In this paper we discuss the potential for semantic search and focus on the most immediate problem toward its realization: the problem of the sparsity and relatively low quality of embedded metadata. We suggest that a part of the solution is to expose users to embedded metadata as part of their daily activity of searching the Web. We present the publicly available microsearch system which enriches search result presentation with metadata extracted from search results and report on some of the early feedback we have received. 1
In-Plane Aromaticity in Double Group Transfer Reactions (2007)

The main features of double group transfer reactions have been studied under the density-functional theory framework. It is found that a wide range of structure-types and processes including type II-dyotropic reactions and the Meerwein-Ponndorf-Verley reduction take place via highly synchronous in-plane aromatic transition structures. Actually, the orbital topology of these saddle points is equivalent to that which corresponds to a D2h-symmetric aromatic molecule such as pyrazine.
Semi-autonomous sounding selection for OCO-2 (2013)

Abstract. Many modern instruments generate more data than may be fully processed in a timely manner. For some atmospheric sounders, much of the raw data cannot be processed into meaningful observations due to suboptimal viewing conditions, such as the presence of clouds. Conventional solutions are quick, empirical-threshold filters hand-created by domain experts to weed out unlikely or unreasonable observations, coupled with randomized down sampling when the data volume is still too high. In this paper, we describe a method for the construction of a sub-sampling and ordering solution that maximizes the likelihood that a requested data subset will be usefully processed. The method can be used for any metadata-rich source and implicitly discerns informative vs. non-informative data features while still permitting user feedback into the final features selected for filter implementation. We demonstrate the method by creating a selector for the spectra of the Japanese GOSAT satellite designed to measure column averaged mixing ratios of greenhouse gases including carbon dioxide (CO2). This is done within the Atmospheric CO2 Measurements from Space (ACOS) NASA project with the intention of eventual use during the early Orbiting Carbon Observatory-2 (OCO-2) mission. OCO-2 will have a 1.5 orders of magnitude larger data volume than ACOS, requiring intelligent pre-filtration.
A 2-GHz wide-band direct conversion receiver for WCDMA applications (1999)

A 2-GHz direct conversion receiver for third-generation mobile communications using wide-band code division multiple access achieves -114-dBm sensitivity for 128-kb/s data at 4.096-Mcps spreading rate. The receiver is distributed on four dies. The active RC channel selection filter can be programmed to three different bandwidths from 5 to 20-MHz radio-frequency (RF) spacing; and the gain control is merged with filtering. RF and baseband chips use a 25-GHz, 0.3-/spl mu/m BiCMOS technology while the two analog-to-digital converters are implemented with a 0.5-/spl mu/m CMOS. The double-sideband noise figure is 5.1 dB at the 94-dB maximum voltage gain, and the IIP3 and ITP2 are -9.5 and +38 dBm, respectively, The receiver draws 128 mA from a 2.7-V supply.
Brillouin lasing in barium ﬂuoride whispering-gallery-mode resonators (2015)

International audience
Pharmacological Studies of Thyrotropin-Releasing Hormone (TRH) Receptors from<i>Xenopus laevis</i>: Is xTRHR3 a TRH Receptor? (2003)

Previously, three receptors, xTRHR1, xTRHR2, and xTRHR3, were cloned from brain tissue of Xenopus laevis with primers designed using sequences from the mammalian TRH receptor (TRHR) subtype 1. We expressed the Xenopus receptors in HEK 293EM cells and studied their binding and signaling properties using a series of TRH analogs substituted at the first, second, and third positions. We observed that the three Xenopus receptors exhibited binding and signaling properties that were distinct. Although xTRHR1 was most similar to mouse TRHR1 (mTRHR1), it exhibited binding affinities that were different from mTRHR1. In contrast to mTRHR2, xTRHR2 exhibited lower affinities and potencies for all TRH analogs than mTRHR1. The xTRHR3 displayed very low affinities and potencies for TRH and TRH analogs and showed little discrimination for TRH analogs; it is likely, therefore, that another peptide is the cognate ligand for xTRHR3. Our findings show differences between TRHR1 and TRHR2 from Xenopus and mammals and suggest that xTRHR3 is a receptor for a ligand other than TRH.
Managing the Risk of Occupational Allergy in the Enzyme Detergent Industry (2013)

Background: Enzyme proteins have long been recognised to have a potential to cause occupational allergy. Consequently, as users of enzymes in formulated products, the detergents manufacturers have chosen to implement a number of control measures to ensure that the hazard does not translate into health effects in the workforce. To that end, the trade associations, the American Cleaning Institute and the International Association for Soaps, Detergents and Maintenance Products, have developed best practice risk management guidelines providing occupational hygiene and medical monitoring as part of an effective exposure control strategy. The need for businesses to recognize the utility of the available guidance is reinforced by reports where factories failure to following good industrial hygiene practices can give rise to incidences of occupational allergy. Aims: In this presentation, an overview is provided of how the industry guidelines are actually implemented in practice and the resulting experience of workplace exposures and health impacts. Methods: Both medical surveillance and air monitoring practices associated with the implementation of industry guidelines at over 100 manufacturing facilities are evaluated with respect to the prevalence of allergic antibody and occupational respiratory allergy. Results and Conclusions: The data show that using the approaches described for the limitation of exposure, for good occupational hygiene, and for active health monitoring, the respiratory allergenic hazard associated with enzyme proteins can been successfully managed to ensure the safety of the workforce.
A new silicon-mediated nitrogen to oxygen rearrangement (1999)

Migration of silicon from nitrogen to oxygen has been quantified with respect to the distance between migration termini, substituents at silicon, and substitution on the chain linking oxygen to nitrogen.