gebhart/patrepeval huggingface dataset:
South Africa: clinical experience with Hemopure (2006)

Bovine‐derived haemoglobin solution (HBOC‐201 – Hemopure®) was first registered for routine clinical use in South Africa for the treatment of adult surgical anaemia. This material was administered to a total of 80 patients as part of a clinical surveillance and educational program from April 2001 until October 2002, and thereafter to a further 256 patients as part of ongoing clinical education and surveillance. This paper reports the clinical details, method of administration, clinical outcome, and safety and efficacy data observed in this cohort of 336 patients. Hemopure was well‐tolerated by these patients, with a considerably lower SAE rate observed in this study than was reported in the HAEM 114 and 115 phase III clinical trials. Avoidance of blood was achieved in about 89% of patients, with blood administration limited to patients with large or rapid haemorrhage and those patients who failed to demonstrate recovery of their own red cell mass after Hemopure treatment due to the presence of underlying chronic disease states. As clinicians became more familiar with the product characteristics and unique physiology of haemoglobin solutions, an increasing tendency has been observed for clinicians to administer Hemopure for its tissue oxygenation effect rather than as a red cell substitute. The role of Hemopure as an enhancer of tissue oxygen delivery and its effect on wound healing, requires further properly controlled randomized prospective studies.
A Universal Protein Tag for Delivery of SiRNA-Aptamer Chimeras (2013)

siRNA-aptamer chimeras have emerged as one of the most promising approaches for targeted delivery of siRNA due to the modularity of their diblock RNA structure, relatively lower cost over other targeted delivery approaches, and, most importantly, the outstanding potential for clinical translation. However, additional challenges must be addressed for efficient RNA interference (RNAi), in particular, endosomal escape. Currently, vast majority of siRNA delivery vehicles are based on cationic materials, which form complexes with negatively charged siRNA. Unfortunately, these approaches complicate the formulations again by forming large complexes with heterogeneous sizes, unfavorable surface charges, colloidal instability, and poor targeting ligand orientation. Here, we report the development of a small and simple protein tag that complements the therapeutic and targeting functionalities of chimera with two functional domains: a dsRNA binding domain (dsRBD) for siRNA docking and a pH-dependent polyhistidine to disrupt endosomal membrane. The protein selectively tags along the siRNA block of individual chimera, rendering the overall size of the complex small, desirable for deep tissue penetration, and the aptamer block accessible for target recognition. More interestingly, we found that extending the c-terminal polyhistidine segment in the protein tag to 18 amino acids completely abolishes the RNA binding function of dsRBD.
Overexpression of a Wheat Aquaporin Gene, TdPIP2;1, Enhances Salt and Drought Tolerance in Transgenic Durum Wheat cv. Maali (2019)

In this study, we generated transgenic durum wheat cv. Maali overexpressing the wheat plasma membrane aquaporin <i>Td</i>PIP2;1 gene under the control of Pr<i>Td</i>PIP2;1 promoter or under the constitutive PrCaMV35S promoter. Histochemical analysis of the fusion Pr<i>Td</i>PIP2;1::<i>Td</i>PIP2;1::GusA in wheat plants showed that the β-glucuronidase (GUS) activity was detected in the leaves, stems and roots of stably transformed wheat T3 plants. Our results showed that transgenic wheat lines overexpressing the <i>Td</i>PIP2;1 gene exhibited improved germination rates and biomass production and retained low Na<sup>+</sup> and high K<sup>+</sup> concentrations in their shoots under high salt and osmotic stress conditions. In a long-term study under greenhouse conditions on salt or drought stress, transgenic <i>Td</i>PIP2;1 lines produced filled grains, whereas wild-type (WT) plants either died at the vegetative stage under salt stress or showed drastically reduced grain filling under drought stress. Performing real time RT-PCR experiments on wheat plants transformed with the fusion Pr<i>Td</i>PIP2;1::GusA, we showed an increase in the accumulation of GusA transcripts in the roots of plants challenged with salt and drought stress. Study of the antioxidant defence system in transgenic wheat <i>Td</i>PIP2;1 lines showed that these lines induced the antioxidative enzymes Catalase (CAT) and Superoxide dismutase (SOD) activities more efficiently than the WT plants, which is associated with lower malondialdehyde and hydrogen peroxide contents. Taken together, these results indicate the high potential of the <i>Td</i>PIP2;1 gene for reducing water evaporation from leaves (water loss) in response to water deficit through the lowering of transpiration per unit leaf area (stomatal conductance) and engineering effective drought and salt tolerance in transgenic <i>Td</i>PIP2;1 lines.
The electrical engineer (1947)

The life of Thomas A. Edison, whose 100th anniversary is being observed this year, truly embodies the spirit of “The electrical engineer” for his contributions have stimulated almost every phase of electrical activity. To men such as Edison and his cofounders of the AIEE, to men whose accomplishments have been deemed worthy of recognition, and to every electrical engineer who simply serves faithfully, the world owes much of its comfort, its efficiency, and its well-being.
20 MW Flywheel frequency regulation plant (2015)

Hazle designed, built, commissioned, and operates a utility-scale 20 MW flywheel energy storage plant in Hazle Township, Pennsylvania (the Hazle Facility) using flywheel technology developed by its affiliate, Beacon Power, LLC (Beacon Power). The Hazle Facility provides frequency regulation services to the regional transmission organization, PJM Interconnection, LLC (PJM), through its participation in PJM’s Regulation Market (a market-based system for the purchase and sale of the Regulation ancillary service). The zero emission Hazle Facility is designed for a 20 year-life over which it is capable of performing at least 100,000 full depth of discharge cycles. To achieve its 20 MW capacity, the Hazle Facility is comprised of two hundred of Beacon Power’s 100 kilowatt (kW)/25 kilowatt/hour (kWh) flywheels connected in parallel. The Hazle Facility can fully respond to a signal from PJM in less than 2 seconds. The Hazle facility was constructed in an economic development zone designated by the Commonwealth of Pennsylvania and its construction relied on local contractors and labor for completion.
QoS-aware Traffic Classification Architecture Using Machine Learning and Deep Packet Inspection in SDNs (2018)

The QoS-aware traffic classification techniques of SDN networks is the basis for network to provide fine-grained QoS traffic engineering. In this paper, we propose an architecture which combines deep packet detection and semi-supervised machine learning of multi-classifier in SDN. This architecture can classify flows into different QoS categories. Based on this, network can achieve fine-grained adaptive QoS traffic engineering. Moreover, through deep packet detection techniques, network can maintain a dynamic flow database. Classifier can adapt to the rapid emergence of network application and fickle traffic characteristics of current network by periodically re-training with the dynamic flow database. Experiments verify that our classification framework can achieve good classification accuracy.
The Clinton Review: presidential documents on the Net (1994)

The administration makes full-text electronic versions of speeches, proclamations, executive orders, press briefings, daily schedules, and other public papers available through multiple channels. The US presidency has indeed arrived on the Internet
Fetal- and uterine-specific antigens in human amniotic fluid (1978)

Summary. Removal of the major maternal serum proteins from second trimester amniotic fluid by antibody affinity chromatography revealed various soluble tissue antigens, of which two were fetal-specific skin proteins and another, of α2-mobility, was specific to the uterus, and was therefore designated alpha-uterine protein (AUP). These proteins could not be detected in maternal serum by antibody–antigen crossed electrophoresis. The concentration of AUP in amniotic fluid reached a maximum between 10 and 20 weeks of gestation, suggesting that there is an influx of uterine protein into the amniotic fluid at this stage of pregnancy.
Solution processable alternating oligothiophene-PEO-block-co-polymers: synthesis and evidence for solvent dependent aggregation (2000)

A new route to oligothiophene–PEO-block-co-polymers has been developed, in which well-defined α-oligothiophene blocks (from bithiophene to sexithiophene) alternate with poly(ethylene oxide) blocks. These materials show high solubility in common organic solvents. UV/visible and fluorescence studies in solution indicate that the oligothiophene segments are molecularly dissolved in good solvents like chloroform. Aggregation of the oligothiophenes occurs in dioxane–water mixtures, which is manifest by shifts of the UV/visible absorption maxima towards the blue and quenching of the fluorescence. An oligothiophene length of three thiophenes (terthiophene) is necessary to observe this aggregation phenomenon.
A High-Resolution Image Sensor (1970)

The Return Beam Vidicon (RBV) camera system features a recently developed sensor which is capable of producing images with a resolution of 4500 TV lines. Discussed here are the operation of RCA's 2-in RBV and how its primary assets are compatible with the system requirements of programs such as the Earth Resources Observation Satellite. The RBV combines the advantages of the conventional storage vidicon ASOS photoconductor and the orthicon electron multiplier. The sensor operates in a slow-scan mode and utilizes the modulated return beam as a signal path to decrease the signal noise. The primary assets of this device are an improved lowlight sensitivity, with higher signal-to-noise ratios than can be obtained with a conventional vidicon, coupled with extremely high resolution. The 4500-line video signal generated in the 1-in format is converted into a high-quality hard copy print by the Laser Beam Image Reproducer (LBIR). — The high image retention characteristic of the photoconductor makes possible the slow-scan readout of a high-definition (100-ft ground resolution from satellite altitudes), nonsmeared image in limited bandwidth. Thus, a three-camera electronically shuttered system can be used to simultaneously photograph a given section of the Earth's surface in three different spectral bands. Data produced by the sequential readout of the three cameras, when superimposed, can be used to generate a sharp multispectral image. The high-resolution, low image distortion (geometric integrity, shading, etc.), characteristic of the RBV, results from the integration of the vidicon with a carefully controlled electron optic and deflection system. Distributed focus coils are used to obtain minimum spot size and proper beam landing over the full format. The image quality of the RBV/LBIR's high-resolution, low-noise picture is comparable with ground reproduction of present-day film and data transfer techniques used in unmanned surveillance satellites.
A continuously adaptive MLSE receiver for mobile communications: algorithm and performance (1997)

The paper presents a Euclidean distance maximum likelihood sequence estimation (MLSE) receiver, based on the Viterbi algorithm (VA), suitable for fading and noisy communications channels, as that specified by the Group Special Mobiles (GSM). In a mobile cellular system, the fast varying channel characteristics, due to the fading and Doppler effects, require adaptive methods to update the channel coefficients to the MLSE receiver. The proposed technique continuously estimates the channel characteristics directly within the metric calculation of the VA. At each step of the VA, the sequence associated to the path with the best metric value (minimum-survivor method) among the survivor paths is used to update the channel estimate (employing conventional adaptive algorithms) throughout the entire informative sequence. However, the detection of the transmitted data sequence is performed by the VA only at the end of each burst. The proposed technique allows simpler receiver implementation and the simulation results show a good performance of this adaptive MLSE receiver in typical GSM environments.
la mayor transgresión sexual de la poesía trovadoresca o la cantiga En tal perfia qual eu nunca vi de Estevan da Guarda (2008)

espanolEn este trabajo se edita y comenta la cantiga En tal perfia qual eu nunca vi de Estevan da Guarda. EnglishThe subject this article pays attention to the literary comment and edition of the cantiga En tal perfia qual eu nunca vi by Estevan da Guarda.
Spectroscopic Ellipsometry Study of the Dielectric Function of Cu(In&lt;sub&gt;1–x&lt;/sub&gt;Ga&lt;sub&gt;x&lt;/sub&gt;)&lt;sub&gt;3&lt;/sub&gt;Se&lt;sub&gt;5&lt;/sub&gt; Bulk Compounds: Identification of Optical Transitions (2017)

Using Spectroscopic Ellipsometry (SE), the optical properties of Cu(In1−xGax)3Se5 bulk compounds, grown by the Bridgman method, were analyzed by varying x composition (0 ≤ x ≤ 1). Energy levels above the gap in the band scheme were determined by measuring the complex dielectric function at room-temperature for energies between 1.5 and 5.5 eV using a variable angle of incidence ellipsometer. The transitions values E1, E2 and E3 were observed above the gap for different samples of Cu(In1−xGax)3Se5 alloy. When a gallium atom replaces an indium atom, one assumes globally that the levels related to selenium and copper are unchanged. Conversely, the levels corresponding to the conduction band are shifted towards higher energies. Thus, the gap increases as the composition of gallium increases. Spectroscopic Ellipsometry (SE) gave evidence for the interpretation of the choice of gap values which were compatible with that obtained from solar spectrum. Several other characterization methods like Energy Dispersive Spectrometry (EDS), hot point probe method, X-ray diffraction, Photoluminescence (PL), Optical response (Photoconductivity) were presented in this paper. The Cu(In1−xGax)3Se5 have an Ordered Vacancy Chalcopyrite-type structure with lattice constants varying as a function of the x composition. The band gap energy of Cu(In1−xGax)3Se5 compounds is found to vary from 1.23 eV to 1.85 eV as a function of x.
Children with sex chromosome variations: implications for pediatric nursing practice. (1986)

Abstract Nursing interventions for children and adolescents with sex chromosome variations are dependent upon one or more variables: the type and severity of problems associated with the variation, the developmental stage of the affected individual, the ability and willingness of the child and family to cooperate in therapeutic approaches, and the availability of resources for therapeutic intervention. Nurses may encounter affected children in all types of settings but particularly in neonatal, pediatric, adolescent-young adult, and mental health settings. The nurse who is knowledgeable about sex chromosome variations can be instrumental in the treatment and referral of children and their families to sources of long-term assistance and support.
Multi-layer screen-space ambient occlusion using hybrid sampling (2013)

Ambient occlusion is a shading method which approximates the global illumination by taking into account attenuation of light due to occlusion[Christensen 2002; Sergey et al. 1998; Andrei et al. 2003]. Screen-space ambient occlusion is a scene-independent improvement which performs the visibility test using depth buffer on GPU in real time. Shanmugam et al. [Shanmugam et al. 2007] proposes a real-time multi-pass hardware assisted ambient occlusion method. The algorithm randomly samples the normal/depth buffer and reconstructs the surface using spheres that can be projected to screen, but has the overocclusion issue. Bavoil et al. [Bavoil et al. 2008] approximates the ambient occlusion illumination using a image-space horizon-based method. However, the scenes will also be overoccluded due to the inconsideration of the layers behind the frontmost one. Moreover, the rough approximation of the geometry occluder makes the shadows lack of rich details. In this paper we propose a new solution to approximate ambient occlusion using a hybrid sampling method of both above methods. The surfaces can be more accurately depicted using spheres and the geometry occluder under the horizon plane can be discarded to address the overocclusion issue. In addition, a multi-layer method is utilized to future alleviate overocclusion using the depth information of all the layers. Experiments show that our algorithm can generate more realistic results for complex scenes with rich details, with comparable performance.
The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin (2010)

These results suggest that: (i) the PI3K/Akt/mTOR pathway is upregulated in murine lupus nephritis, thus justifying treatment with rapamycin; (ii) rapamycin not only blocks mTOR but also negatively regulates the PI3K/Akt/mTOR pathway; and (iii) rapamycin is an effective treatment of murine lupus nephritis. Examination of the PI3K/Akt/mTOR pathway may offer new insights into the pathogenesis of lupus nephritis in humans and may lead to more individualized and less toxic treatment.
A co-design approach for embedded system modeling and code generation with UML and MARTE (2009)

In this paper we propose a UML/MDA approach, called MoPCoM methodology, to design high quality real-time embedded systems. We have defined a set of rules to build UML models for embedded systems, from which VHDL code is automatically generated by means of MDA techniques. We use the MARTE profile as an UML extension to describe real-time properties and perform platform modeling. The MoPCoM methodology defines three abstraction levels: abstract, execution and detailed modeling levels (AML, EML and DML, respectively). We detail the lowest MoPCoM level, DML, design rules in order to perform automatically VHDL code generation. A viterbi coder has been used as a first case study.
Leader Election in Distributed Systems with Crash Failures (1999)

Leader election is an important problem in distributed computing. Garcia-Molina&apos;s Bully Algorithm is a classic solution to leader election in synchronous systems with crash failures. This paper shows that the Bully Algorithm can be easily adapted for use in asynchronous systems. First, we re-write the Bully Algorithm to use a failure detector, instead of explicit time-outs; this yields a modular solution to leader election in synchronous systems. Second, we show that minor modifications to that algorithm yield a simple and efficient solution to leader election in asynchronous systems with crash failures. We point out a flaw in Garcia-Molina&apos;s specification of leader election in asynchronous systems, propose a revised specification, and show that the modified Bully Algorithm satisfies this specification. Keywords: leader election, synchronous, asynchronous, crash failures, failure detector 1 Introduction In a classic paper, Garcia-Molina specifies the leader election problem for synch...
Silk fibroin hydrolysate inhibits osteoclastogenesis and induces apoptosis of osteoclasts derived from RAW 264.7 cells (2012)

Bone disease can be associated with bone resorption by osteoclasts, and interest in the development of antiresorptive agents has recently increased. The hydrolysate of silk fibroin has been studied with respect to such biomedical applications. In a previous study, silk fibroin showed indirect inhibitory effects on the differentiation of osteoclasts. To further evaluate the effect of a hydrolysate of silk fibroin on osteoclasts, we investigated the direct effects of the silk fibroin hydrolysate on osteoclastogenesis and apoptosis of osteoclasts induced by receptor activation of nuclear factor κB ligand (RANKL). The silk fibroin hydrolysate inhibited RANKL-induced formation of tartrate-resistant acid phosphatase (TRAP) in RAW 264.7 cells. The inhibitory effect of the silk fibroin hydrolysate resulted in the decreased expression of osteoclast marker genes, such as matrix metalloproteinase-9 (MMP-9), cathepsin-K and calcitonin receptor (CTR). In addition, the silk fibroin hydrolysate blocked the signaling pathways of mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) and expression of transcription factors, such as nuclear factor of activated T cells c1 (NFATc1) and NF-κB. Finally, the silk fibroin hydrolysate induced apoptosis signaling cascades. Taken together, the present results indicate that silk fibroin hydrolysate has antiresorptive activity by both inhibiting osteoclastogenesis and inducing osteoclast apoptosis.
Enhanced Autofocus Algorithm Using Robust Focus Measure and Fuzzy Reasoning (2008)

A new passive autofocus algorithm consisting of a robust focus measure for object detection and fuzzy reasoning for target selection is presented. The proposed algorithm first detects objects distributed in the image using a mid-frequency discrete cosine transform focus measure and then selects the target object through fuzzy reasoning with three fuzzy membership functions. The proposed algorithm is designed as full digital blocks and fabricated using 0.35-mum CMOS technology. Experimental results obtained from various samples show that the present method is insensitive to Gaussian and impulsive noises and able to improve the quality of the image by focusing to the appropriate target object.
Performance issues and optimizations in JavaScript (2016)

As JavaScript is becoming increasingly popular, the performance of JavaScript programs is crucial to ensure the responsiveness and energy-efficiency of thousands of programs. Yet, little is known about performance issues that developers face in practice and they address these issues. This paper presents an empirical study of 98 fixed performance issues from 16 popular client-side and server-side JavaScript projects. We identify eight root causes of issues and show that inefficient usage of APIs is the most prevalent root cause. Furthermore, we find that most issues are addressed by optimizations that modify only a few lines of code, without significantly affecting the complexity of the source code. By studying the performance impact of optimizations on several versions of the SpiderMonkey and V8 engines, we find that only 42.68% of all optimizations improve performance consistently across all versions of both engines. Finally, we observe that many optimizations are instances of patterns applicable across projects, as evidenced by 139 previously unknown optimization opportunities that we find based on the patterns identified during the study. The results of the study help application developers to avoid common mistakes, researchers to develop performance-related techniques that address relevant problems, and engine developers to address prevalent bottleneck patterns.
A novel technique of AC power control using micro controller based inverter (2008)

Several techniques have been developed to control alternating current (AC) power. In this paper we put forward, a novel technique to design and implement a single phase PWM inverter using simple 8051 microcontroller rather than using digital signal processor (DSP) controllers . The main features of 8051 based PWM inverter are simpler design, low cost, maximum range of voltage control and compact in size. The designed PWM inverter is tested on various AC loads like AC motor and intensity control of incandescent lamp in a closed loop environment.