gebhart/patrepeval huggingface dataset:
Model-based interference cartography and visualization (2016)

In this work, we present a tool to construct and visualize the spatio-temporal variations of power. A dataset of real-world power measurements is collected over a geographical area of interest. Relevant parameters of the environment such as the path loss exponent and the decorrelation time of the lognormal shadow fading are extracted from the dataset. Also, the average powers measured at a finite set of known locations are interpolated to obtain the average power distribution over the area. Using the parameters of the lognormal shadow fading, synthetic data with the same temporal behavior of the dataset is generated, and multiplied with the average power distribution. The resulting spatio-temporal power map is displayed on the screen through a graphical user interface developed in-house. The proposed approaches for interpolation and parameter extraction are validated using test datasets generated using the well-accepted modified Gudmundson model for the spatio-temporal correlation of lognormal shadow fading. We also undertake a comparative study of three different interpolation techniques: linear interpolation, inverse distance weighing and ordinary kriging. Further, we compare a model-based approach with a model-free approach for interpolation, and find that model-based ordinary kriging provides the best mean absolute percentage error performance.
Linear optimization of antenna array for radiation pattern defined on a planar surface (2018)

In this contribution, the antenna array synthesis for radiation pattern defined on a planar surface is described. This can be required when the electric field r-decay factor effect cannot be neglected, e.g. an antenna array mechanically tilted and a specific pattern defined in terms of cartesian coordinates. Differently from the classical sidelobe level reduction optimization problem, the case in which both a constant power bounded area and a sidelobe suppression region are defined and required to be synthesized is herein addressed. The general nonlinear optimization problem is first presented; then, the derivation of some sub-optimal linear problems based on practical implementation hypothesis is described, with the advantage of a reduced computational complexity. Numerical results validate the effectiveness of the proposed method.
Endothelial nitric oxide synthase and its negative regulator caveolin-1 localize to distinct perinuclear organelles. (2002)

International audience
Wear Mechanisms of Multi-Layer Coated Cemented Carbide Cutting Tools (1997)

Turning experiments were performed with cemented WC-Co cutting tools coated with two-layer and three-layer overcoats of TiC/Al2O3 and TiC/Al2O3/TiN, respectively. For comparison, uncoated WC-Co tools were also tested under similar cutting conditions. The predominant wear mechanisms of the various ceramic overcoats and cemented WC-Co were investigated using surface profilometry, scanning electron microscopy, and energy dispersive X-ray analysis. Representative results of the tool wear behavior are presented, and the significance of each ceramic layer on the overall tool wear resistance is interpreted in light of the identified dominant wear mechanisms. Delamination wear characterized by the propagation and linkage of surface, subsurface, and interfacial cracks, abrasion, surface plastic shearing, plucking of carbide grains, and dissolution/diffusion are shown to occur depending on the tool material. These wear processes are not mutually exclusive; they may occur simultaneously at different positions on the same tool surface. Based on nose wear data, correlations between wear lives of coated and uncoated tools and feedrate are established.
Toward an Understanding of the Mechanism of Nonphotochemical Quenching in Green Plants (2004)

Oxygenic photosynthesis in plants involves highly reactive intermediates and byproducts that can damage the photosynthetic apparatus and other chloroplast constituents. The potential for damage is exacerbated when the amount of absorbed light exceeds the capacity for light energy utilization in photosynthesis, a condition that can lead to decreases in photosynthetic efficiency. A feedback de-excitation mechanism (qE), measured as a component of nonphotochemical quenching of chlorophyll fluorescence, regulates photosynthetic light harvesting in excess light in response to a change in thylakoid lumen pH. qE involves de-excitation of the singlet excited state of chlorophyll in the light-harvesting antenna of photosystem II, thereby minimizing the deleterious effects of high light via thermal dissipation of excess excitation energy. While the physiological importance of qE has been recognized for many years, a description of its physical mechanism remains elusive. We summarize recent biochemical and spectroscopic results that have brought us closer to the goal of a mechanistic understanding of this fundamental photosynthetic regulatory process.
Ring Fusion and Heteroatom Effects in Low Band Gap Conjugated Polymers for OFET Applications (2013)

Abstract not Available.
4‐Substituted Cyclohexyl Sulfones as Potent, Orally Active γ‐Secretase Inhibitors. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Computing with Register Machines (1996)

This chapter contains sections titled: Designing Register Machines, A Register-Machine Simulator, Storage Allocation and Garbage Collection, The Explicit-Control Evaluator, Compilation
Fas-Mediated Apoptosis in Ewing's Sarcoma Cell Lines by Metalloproteinase Inhibitors (1999)

MMPIs cause accumulation of transmembrane FasL by inhibiting its cleavage, accumulation of Fas (probably secondarily to FasL cleavage inhibition), and decreased levels of soluble FasL. These effects lead to apoptosis in Fas-sensitive cell lines. The observed cooperative action of MMPIs and doxorubicin suggests a possible role of MMPIs in combination treatments with standard apoptosis-inducing chemotherapeutic agents.
KINETIC COLLISION DETECTION FOR SIMPLE POLYGONS (2002)

We design a simple and elegant kinetic data structure for detecting collisions between polygonal (but not necessarily convex) objects in motion in the plane. Our structure is compact, maintaining an active set of certificates whose number is proportional to a minimum-size set of separating polygons for the objects. It is also responsive; on the failure of a certificate invariants can be restored in time logarithmic in the total number of object vertices. It is difficult to characterize the efficiency of our structure for lack of a canonical definition of external events. Nevertheless we give an easy upper bound on the worst case number of certificate failures.
Murine interferon-beta receptor-mediated endocytosis and nuclear membrane binding. (1985)

Radioiodinated mouse interferon-beta (125I-MuIFN-beta) bound with high affinity (Kd = 9.8 X 10(-10) M) to plasma membrane of L929 murine fibroblasts (4-6 X 10(3) receptor sites per cell). The binding was saturable and inhibited by a 100-fold excess of unlabeled MuIFN-beta but not by excess mouse IFN-gamma (MuIFN-gamma). MuIFN-beta bound at 4 degrees C was very rapidly internalized upon warming of the cells to 37 degrees C (t 1/2 = 1.5 min). Indirect immunoferritin labeling indicated that MuIFN-beta was initially located in coated pits and subsequently internalized by receptor-mediated endocytosis. Isolated L929 cell nuclei bound 125I-MuIFN-beta with a 7-fold higher affinity (Kd = 1.4 X 10(-10) M) and higher receptor density (about 10(4) per nucleus) than that for the plasma membrane. Binding to the nuclear membrane was inhibited by a 100-fold excess of unlabeled MuIFN-beta but not by excess MuIFN-gamma. Trypsin treatment of nuclei decreased IFN binding by 80%, suggesting that the putative nuclear receptors are protein. Specific binding of MuIFN-beta to nuclei was also shown by fluorescence and electron microscopy. We propose that the very rapid internalization of MuIFN-beta by receptor-mediated endocytosis is important in the cellular processing of IFN and that its high-affinity binding to the nuclear membrane suggests the nucleus as an intracellular site of IFN action.
Continuous Fermentation of Novobiocin (1961)

Continuous fermentation trials with Streptomyces niveus in a nine-stage fermentation system (7-liter reaction volume per stage) indicated that the cultures used gradually lost their ability to produce novobiocin when cultured over periods from 10 to 25 days. It was found that mycelial degeneration could be circumvented by operational means during continuous culture using the following technique: Two interchangeable 24-liter stages were installed at the front end of the nine-stage system and connected in parallel with the latter. Alternatingly one of these two tanks was then used as first stage of the continuous fermentation system. The holdup time in the first vessel was adjusted to limit cell growth chiefly to this stage so that most of the antibiotic production took place in subsequent stages. The first stages were switched at approximately weekly intervals. Each of the new tanks was prepared as a batch, inoculated with a high-producing cell population, and allowed to grow for 3 days before it was connected to the remaining system for continuous operation. Using this technique no evidence of culture degeneration was encountered in subsequent novobiocin production stages over a period of 33 days. In conventional runs without periodic replacement of the first stage, culture degeneration with the novobiocin fermentation occurred within a period of 10 to 25 days of continuous operation. This observation indicates that the described technique offers a solution to the problem of maintaining high steady-state titers in continuous novobiocin fermentations. Extension of this technique to other continuous fermentations where culture degeneration is a problem is indicated.
A Metastable State of Torpedo californica Acetylcholinesterase Generated by Modification with Organomercurials (1994)

Chemical modification of Torpedo californica acetylcholinesterase by various sulfhydryl reagents results in its conversion to one of two principal states. One of these states, viz., that produced by disulfides and alkylating agents, is stable. The second state, produced by mercury derivatives, is metastable. At room temperature, it converts spontaneously, with a half-life of ca. 1 h, to a stable state similar to that produced by the disulfides and alkylating agents. Demodification of acetylcholinesterase freshly modified by mercurials, by its exposure to reduced glutathione, causes rapid release of the bound mercurial, with concomitant recovery of most of the enzymic activity of the native enzyme. In contrast, similar demodification of acetylcholinesterase modified by disulfides yields no detectable recovery of enzymic activity. Spectroscopic measurements, employing CD, intrinsic fluorescence, and binding of 1-anilino-8-naphthalenesulfonate, show that the state produced initially by mercurials is "native-like", whereas that produced by disulfides and alkylating agents, and after prolonged incubation of the mercurial-modified enzyme, is partially unfolded and displays many of the features of the "molten globule" state. Arrhenius plots show that the quasi-native state produced by organomercurials is separated by a low (5 kcal/mol) energy barrier from the native state, whereas the partially unfolded state is separated from the quasi-native state by a high energy barrier (ca. 50 kcal/mol). Comparison of the 3D structures of native acetylcholinesterase and of a heavy-atom derivative obtained with HgAc2 suggests that the mercurial-modified enzyme may be stabilized by additional interactions of the mercury atom attached to the free thiol group of Cys231, specifically with Ser228O gamma with the main-chain nitrogen and carbonyl oxygen of the same serine residue.
Comparison of Devices for Measuring Cherry Fruit Firmness (1998)

The performance of three relatively new nondestructive cherry firmness devices and a penetrometer were evaluated and compared with the firmness testing performance of an Instron Universal Testing Machine. The inherent variability of the nondestructive devices was estimated by repeated measurement of a uniform, symmetrical, and resilient rubber ball. Analysis of residuals from correlations between each device and the Instron from firmness testing on common samples of sweet cherries ( Prunus avium L.) confirmed the relative variability of the nondestructive devices, and estimated measurement reliability of the penetrometer. Subjective firmness sensing by compression of cherries between the fingers of human evaluators proved to be less reliable than the devices tested. Sweet cherry firmness correlated reasonably well with skin color, with the strength of the correlations from each device agreeing with device ranking in terms of firmness measurement reliability. Firmness correlated poorly with soluble solids, titratable acidity, and specific gravity; soluble solids correlated well with specific gravity; and skin color correlated reasonably well with both soluble solids and specific gravity. Fruit surface pit volume, induced by a specific impact force from a ball bearing, correlated relatively well with fruit firmness measured by the penetrometer, but poorly or inconsistently with measurements from the remaining firmness devices.
Fahrzeugumfelderfassung über eine kombinierte Multi-Level Datenfusion konkurrierender Sensoren (2012)

Ein Sensorsystem, bestehend aus einem Laserscanner und einem Stereokamera-System, wird zur Fahrzeugumfelderfassung eingesetzt. Die heterogenen Sensorinformationen werden auf unterschiedlichen Verarbeitungsebenen über ein neuartiges Multilevel-Multisensor Fusions-Framework parallel fusioniert. Über eine Top-Down-Zusammenführung der Fusions-Ergebnisse können die Vorteile der einzelnen Ebenen kombiniert und die Nachteile kompensiert werden. Im Folgenden werden das Framework und die einzelnen Verfahren zur Datenfusion vorgestellt. Die vorgestellten Verfahren werden abschließend anhand realer Messdaten validiert.
Stress relaxation behind elastic shock waves in rocks (1966)

The amplitude of elastic shock waves in Arkansas novaculite is observed to decrease at a rate of ≈3.3 kb/mm for shock propagation path lengths of 6 to 12 mm. The amplitude of the final shock state in the experiments is held near the 155-kb pressure level. A total variation of elastic shock wave amplitude (Hugoniot elastic limit) of ≈40 kb (from 110 to 70 kb) is observed in ≈1 cm of shock travel. The intrinsic attenuation term in a constitutive equation for a stress-relaxing elastoplastic material is found to account for ≈90% of the observed peak pressure attenuation of the elastic shock, as compared with the ≈10% which is predicted from the instantaneous elastic shock profile. The Hugoniot elastic limits of Sioux and Eureka quartzites, which were not as intensively studied as the Arkansas novaculite, are also found to decrease with shock propagation path length.
Time Course of Protein Synthesis-Dependent Phase of Olfactory Memory in the Cricket Gryllus bimaculatus (2003)

The cricket Gryllus bimaculatus forms a stable olfactory memory that lasts for practically a lifetime. As a first step to elucidate the cellular mechanisms of olfactory learning and memory retention in crickets, we studied the dependency of memory retention on the de novo brain protein synthesis by injecting the protein synthesis inhibitor cycloheximide (CHX) into the head capsule. Injection of CHX inhibited (3)H-leucine incorporation into brain proteins by > 90% for 3 hr. Crickets were trained to associate peppermint odor with water (reward) and vanilla odor with saline solution (non-reward) and were injected with CHX before or at different times after training. Their odor preferences were tested at 2 hr, 1 day and 4 days after training. Memory retention at 2 hr after training was unaffected by CHX injection. However, the level of retention at 1 day and 4 days after training was lowered when CHX was injected 1 hour before training or at 1 hr or 6 hr after training. To study the time course of the development of CHX-sensitive memory phase, crickets that had been injected with CHX at 1 hr after training were tested at different times from 2 to 12 hr after training. The level of retention was unaffected up to 4 hr after training but significantly lowered at 5 hr after training, and the CHX-sensitive memory phase developed gradually during the next several hours. CHX dissociates two phases of olfactory memory in crickets: earlier protein synthesis-independent phase (< 4 hr) and later (> 5 hr) protein synthesis-dependent phase.
Receptor‐Mediated Targeting of Phthalocyanines to Macrophages <i>Via</i> Covalent Coupling to Native or Maleylated Bovine Serum Albumin (1999)

Abstract— Targeted delivery of aluminum tetrasulfophthalocyanine (AlPcS 4 ) to the scavenger receptor of macrophages, via coupling to maleylated bovine serum albumin (mal‐BSA), was explored as a means to improve photodynamic efficacy. The AlPcS 4 was covalently coupled to BSA (9:1 molar ratio) via one or two sulfonamide‐hexanoic‐amide spacer chains, followed by treatment with maleic anhydride to yield the mal‐BSA‐phthalocyanine conjugates. The latter were tested for singlet oxygen production, receptor‐mediated cell uptake and phototoxicity toward J774 cells of macrophage origin and nonphagocytic EMT‐6 cells. Cell uptake of 125 I‐mal‐BSA showed specific binding for J774 cells but not for EMT‐6 cells. Competition studies of the conjugates with 125 I‐mal‐BSA showed that coupling of AlPcS 4 to BSA resulted in recognition of the conjugate by the scavenger receptor, whereas coupling to mal‐BSA further enhanced its binding affinity. This suggests that affinity for the scavenger receptor is related to the overall negative charge of the protein. Phototoxicity of the conjugates toward J774 cells paralleled their relative affinity, with mal‐BSA‐AlPcS 4 coupled via two spacer chains showing the highest activity. The conjugates were less phototoxic toward the EMT‐6 cell line. The activities in both cell lines of all conjugated AlPcS 4 preparations were, however, lower than that of the free disulfonated AlPcS 2 . Possible implications for the in vivo use of protein‐photosensitizer conjugates to target selectively various macrophage‐associated disorders is discussed.
EFFECTS OF CHLOROCHOLINE AND RELATED COMPOUNDS ON THE GROWH AND OTHER CHARACTERISTICS IN SEVERAL VEGETABLE CROPS (1992)

A series of experiments were conducted to investigate the effects of chlorocholine and similar compounds such as choline, chlorocholine chloride (CCC or chlormequat) and other compounds on the rooting and seedling quality for transplanting. The growth of shoot and root and the ratio of shoot/root were influenced and consequently the seedling quality was improved by chlorocholine treatment. Mungbean bioassays for plant hormone revealed that rooting was promoted and shoot growth or stem elongation was inhibited by the treatment. Addition of other PGRs such as atonik, vitamins and surfactants to chlorocholine solution significantly promoted the rooting of mungbean cuttings as well as the rooting of cutting of sweet potato, cucumber, and watermelon.
Multilayer thin-film design as far-ultraviolet polarizers (1993)

We use a concept of induced transmission and absorption to design multilayer thin film reflection polarizers in the FUV region. We achieve high s-polarization reflectance and a high degree of polarization by means of a MgF2/Al/MgF2 three layer structure on an opaque thick film of aluminum as the substrate. For convenience they are designed at a 45 deg angle of incidence. For example, our polarizer designed for the Lyman-alpha line (121.6 nm) has 88.67 percent reflectance for the s-polarization case, and 1.21 percent for the p-polarization case, with a degree of polarization of 97.31 percent. If we make a double surface polarizer with this design, it will have a degree of polarization of 99.96 percent and s-polarization throughput of 78.62 percent.
Heparin binding, internalization, and metabolism in vascular smooth muscle cells: II. Degradation and secretion in sensitive and resistant cells (1995)

Smooth muscle cell (SMC) proliferation plays a critical role in several pathological states, including atherosclerosis and hypertension. Heparin suppresses SMC proliferation in vivo and in culture, but the mechanism of action is still poorly understood. In an accompanying article in this issue (Letourneur et al. [1995] J. Cell Physiol., 165:676-686), we observed that heparin binding was up-regulated in heparin-sensitive SMC but was rapidly down-regulated in heparin-resistant SMC continuously exposed to heparin. In this communication, we examine the degradation and secretion of internalized heparin in sensitive and resistant SMC, using gel filtration chromatography to analyze heparin degradation products. Pulse-chase experiments using radiolabeled heparin indicate that sensitive and resistant SMC secrete heparin during the first few hours after exposure. Experiments in which cells are continuously exposed to heparin indicate that degradation and secretion occur in both sensitive and resistant SMC for approximately 5-8 hr. After that time, however, binding and internalization in resistant SMC rapidly decrease and degradation and secretion stop. In contrast, heparin binding and uptake continue in sensitive SMC; degradation and secretion also continue. Chloroquine prevents degradation in both sensitive and resistant SMC, suggesting that catabolism occurs in the lysosomal compartment. The results presented in this and the accompanying article (Letourneur et al. [1995] J. Cell. Physiol., 165:676-686) suggest that heparin acts to upregulate its receptors, and that increased binding of heparin is required for the antiproliferative response. Degradation and secretion kinetics parallel the internalization kinetics and appear to be strongly linked to the binding process.
A simulation model for emergency medical services call centers (2015)

In pre-hospital health care the call center plays an important role in the coordination of emergency medical services (EMS). An EMS call center handles inbound requests for EMS and dispatches an ambulance if necessary. The time needed for triage and dispatch is part of the total response time to the request, which, in turn, is an indicator for the quality of EMS. Calls entering an efficient EMS call center must have short waiting times, centralists should perform the triage efficiently and the dispatch of ambulances must be adequate and swift. This paper presents a detailed discrete event simulation model for EMS call centers. The model provides insight into the EMS call center processes and can be used to address strategic issues, such as capacity and workforce planning. We analyse results of the model that are based on real EMS call center data to illustrate the usefulness of the model.