gebhart/patrepeval huggingface dataset:
Atypical Takotsubo syndrome during anagrelide therapy (2009)

Anagrelide is a phosphodiesterase III inhibitor utilized in the treatment of essential thrombocythemia. Anagrelide can be responsible for positive inotropic and chonotropic activity of the cardiovascular system. Moreover, it can induce vasospam directly on the epicardial coronary arteries. In the literature, it is well reported that this inhibitor can determine serious cardiovascular side effects, including congestive heart failure, arrhythmia and acute coronary syndrome. We describe the case of a 75-year-old woman who developed a mid-ventricular Takotsubo syndrome while on anagrelide therapy. Takotsubo cardiomyopathy, also known as left ventricular ballooning syndrome, is characterized by a reversible ventricular contractile dysfunction with akinesis and expansion of apical segments and hyperkinesis of the basal segments. Recently, atypical cases with akinesia and dilation of mid-ventricular segment and hypercontraction of the apical segments, also called mid-ventricular and inverted Takotsubo syndrome, have been described. Even though the pathogenesis of Takotsubo syndrome is poorly understood, several mechanisms have been proposed, including catecholamine-induced myocardial stunning, and ischemia-mediated stunning due to multivessel epicardial or microvascular spasm. We think that in our case, the adverse response of anagrelide therapy was determined, by accumulated dosage of the drug, through an intensive inotropic stimulation and a sympathetic hyperactivation in a vulnerable myocardium. To our knowledge, this is one of the first reports of an association between anagrelide therapy and Takotsubo cardiomyopathy.
Bone Marrow Aspiration for Regenerative Orthopedic Intervention: Technique with Ultrasound Guidance for Needle Placement (2017)

Ultrasound guidance can improve accuracy of bone marrow aspirations form the iliac crest. Mastery of this procedure will facilitate cell harvest and aid in patient safety when procuring mesenchymal stem cells from a bone marrow source.
Diffing, patching and merging XML documents (2010)

This work addresses what we believe to be a central issue in the field of XML diff and merge computation: the mathematical modeling of the so-called "editing deltas" and the study of their formal abstract properties. We expect at least three outputs from this theoretical work: a common basis to compare performances of the various algorithms through a structural normalization of deltas, a universal and flexible patch application model and a clearer separation of patch and merge engine performance from delta generation performance. Moreover, this work could inspire technical approaches to combine heterogeneous engines thank to sound delta transformations. This short paper reports current results, discusses key points and outlines some perspectives.
Clinical analysis of laparoscopic cholecystectomy in the treatment of acute calculous cholecystitis: a re-port of 76 cases (2009)

Objective To explore the way and operation technique of laparoscopic cholecystectomy(LC) in the treatment of acute calculous cholecystitis. Methods We analyzed the data of 76 cases of acute calculous cholecystitis undergoing LC between Sep. 2005 and Feb. 2008 retrospectively. Rusults Except for 5 cases conver-ted to laparotomy,other operations were successfully performed and non severe complications occured. Conclusions LC is a safe and ideal method with advantages of minimal invasion. Less bleeding rapid recovery low postoperative complications and short hospitalization low postoperative complications and short hospitalization.

Key words: 
Acute calculous cholecystitis;  Cholecystectomy;  Operation technique;  Laparoscopy
Expressing Quality of Service in Agent Communication (2001)

An agent communication language (ACL) provides a mechanism for agents to express their desires and intentions to other agents in a content language independent manner. Agents can converse about what they know and what they want to know from other agents. This sharing of information allows multiple agents to work together to meet common goals as well as individual goals. However, in some applications, it is not enough for one agent to let another agent know that it wants some information. A requesting agent must also be able to express something about how it wants the information to be delivered. In general, it is important for an agent to be able to express a desired quality of service (QoS) as part of a communication with another agent. Further, it also is necessary for agents to be able to express the level of quality that it can provide to other agents in the services that it can offer. In this paper, the authors present a methodology for expressing QoS in the capabilities of agents and in the requirements of agents. Section 2 defines the semantics of QoS in agent communication by extending the semantics of a well-known communication language: Knowledge Query Manipulation Language (KQML). Section 3 presents extensions to KQML that allow for the expression of QoS in the language. Section 4 briefly describes a prototype that they have implemented to demonstrate the use of these language extensions. Section 5 concludes with a summary and discussion of the applicability of their work.
Stem-loop 1 of the U1 snRNP plays a critical role in the suppression of HIV-1 polyadenylation (2000)

The inactivity or occlusion of the HIV-1 poly(A) signal when in the 5' long terminal repeat (LTR) has been mechanistically investigated. First we show that neither the homologous HIV-1 promoter nor the close proximity of this RNA processing signal to the transcript initiation site is required for the occlusion effect. Instead we demonstrate that the major splice donor (MSD) site positioned about 200 bp downstream maintains the poly(A) site in an inactive state. Although mutation of MSD results in activation of the 5' LTR poly(A) signal, this effect can be suppressed by targeting U1 snRNAs near to the mutated MSD by base pairing. We show that hybrid U7-U1 snRNAs can also suppress the poly(A) signal and that this suppression is dependent on the U1 stem-loop 1. In particular the binding site for the U1 snRNP protein 70K that binds to the loop structure of stem-loop 1 is associated with poly(A) site occlusion. These experiments were carried out with an HIV-1 proviral construct and as such emphasize the physiological importance of this splice donor-poly(A) site interaction.
The Influence of Heel Height on Frontal Plane Ankle Biomechanics: Implications for Lateral Ankle Sprains (2012)

Data obtained from this investigation highlights the need for increased awareness and proper education related to the wearing of high heel shoes.
Thermolyse von ν‐Triazoly‐Derivaten (1970)

Abstract Heterocyclen mit Chlor in Nachbarstellung zum Ringstickstoff reagieren bei 60–160° mit ν‐Triazol zu den entsprechenden ν‐Triazolyl‐(1)‐Derivaten ( 3 ) oder weiter unter Stickstoffabspaltung zum kondensierten Imidazo‐Heterocyclus. Von den ν‐Triazolyl‐( 1 )‐Derivaten konnte nur das Pyrimidin‐Derivat 3c durch Thermolyse in Polyphosphorsäure in das entsprechende Imidazo‐pyrimidin 4 übergeführt werden. Die übrigen erleiden andersartige, zu undefinierten Produkten führende Zersetzung.
The Effect of a 12‐Month Exercise Trial on Balance, Strength, and Falls in Older Women: A Randomized Controlled Trial (1995)

These findings show that exercise can produce long-term benefits with regard to improving sensorimotor function in older persons. The findings also suggest that high compliance to an exercise program may reduce falls frequency, although further studies are required to conclusively demonstrate that exercise offers an effective means of preventing falls.
단보 : PCR 분석에의한 벼 BAC Library 의 효율적인 선발 (1998)

作物의 genome 연구를 위한 전제 조건은 큰 DNA 단편을 가지는 遺傳子 銀行의 작성이며, 遺傳子 銀行이 작성되면 효과적으로 clone을 選拔하여 Physical map을 작성하는 방법이다. 최근 벼 등 여러 작물에서 작성된 BAC 또는 YAC library에서 clone을 효과적으로 선발하기 위하여 Polymerase Chain Reaction (PCR) 기법을 적용하는데, 이 기법은 遺傳子銀行 전체 clone의 DNA를 조합하는 방법에 따라 分析量 및 效率 등이 큰 차이를 보인다. 18,432개 BAC clones (48개 microtiter plates; 24×16)으로 구성된 벼 遺傳子銀行에서 STS (sequence tagged sites)-PCR 분석으로 효과적인 overlapping RAC contigs 작성을 위해 BAC clone DNA의 組合 方法에 대한 실험을 수행하였으며, 그 결과를 요약하면 다음과 같다.
1. 1단계 PCR 분석을 위한 88개 전체 pool-DNA 組合은 48개 각 plate들의 384개 clone DNA의 조합, 16개 row 각각에서 48개 plate의 clone DNA (16×48, 768 clones)의 조합 및 24개 column 각각에서 48개 plate의 clone DNA (24×48, 1,152 clones)를 조합하였다.
2. 2단계 PCR 분석을 위한 subpool DNA는 48개 각 plate로부터 16개 row (24 clones) 및 24개 column (16 clones)의 clone DNA를 각각 조합하였다.
3. 1단계 STS-PCR 분석은 88개 전체 pool-DNA를 이용하여 positive plates, positive rows 및 positive columns을 選拔하고, positive plate 각각에서 positive rows 및 columns의 subpool-DNA를 주형으로 하여 2단계 PCR 분석을 하였다. 분석된 각 plate에서 positive row 및 column의 조합으로 single BAC clones를 선발하였고, 선발된 single clone의 DNA를 이용한 3단계 PCR 분석으로 최종 확인하였다.
4. 본 실험의 DNA 組合 方法에 의한 STS-PCR 選拔 效率性을 확인하기 위하여 한개 STS primer 분석으로 2개 이상 선발된 clone들에 대해 Southern 분석을 한 결과 96.2%의 선발정확도를 보였다.
Sinan: ML-based and QoS-aware resource management for cloud microservices (2021)

Cloud applications are increasingly shifting from large monolithic services, to large numbers of loosely-coupled, specialized microservices. Despite their advantages in terms of facilitating development, deployment, modularity, and isolation, microservices complicate resource management, as dependencies between them introduce backpressure effects and cascading QoS violations.
Methylene blue supravital staining: an evaluation of its applicability to the mammalian brain and pineal gland. (1998)

Methylene blue supravital staining of mammalian brain reveals typical staining patterns in different brain regions. Within the cerebellum of the mouse, the dye showed a peculiar affinity for the somata and the axons of Purkinje cells. Additionally, large polymorphic neurons characterized by long descending axons were detected within the granular layer and the white matter. These cells might represent another type of projection neuron. In the stratum pyramidale and stratum oriens of the murine hippocampus, a subpopulation of non-pyramidal cells, i.e. intrinsic interneurons, were selectively stained. Additionally, a labelling of perineuronal nets of extracellular matrix covering single cells could be achieved; this phenomenon might be due to the occurrence of strong anionic residues which attract the cationic dye. Therefore, perineuronal nets might also trap other cations and play an important role in the control of cell excitability. The electron microscopic investigation revealed drop-like dye accumulations within the cytoplasm and a staining of material at the site of the plasma membrane. Throughout the pineal gland, a network of a subpopulation of polymorphic cells with manifold long processes could be visualized. Syncytial connections of cells seemed to occur. The oxygen-dependent selective staining is probably functionally connected with the generation of oxygen radicals and subsequent oxidative stress for the cells. This reaction indicates a certain vulnerability to hypoxia; therefore, the intracellular dye-uptake might be interpreted as an early sign of metabolic disturbance.
Pesky home networks trouble cable behemoths (2002)

Are wireless router users stealing broadband Internet access? The author discusses the application of the NAT (network address translation ) protocol into wireless routers which allows several computers to share a single Internet address. Wireless networks using NAT connect with a cable or DSL modem and then the whole wireless network has Internet access.
Experimental observation and simulation of mode-locking phenomena in coupled-oscillator arrays (1992)

Systems of coupled oscillators possess a wealth of interesting and useful nonlinear dynamical phenomena. Arrays of coupled oscillators have been used to model complicated biological and neural activity, and have proved useful in power-combining applications. The analysis of such arrays is difficult, and has generally been restricted to the case where all oscillators are synchronized to a common frequency through the phenomenon of injection locking. When the natural (or free-running) frequencies are very widely distributed, this mutual synchronization is impossible, and the system can exhibit chaotic behavior. However, by carefully choosing the frequency distribution, a stable mode-locked state can be established in which the collective output of the oscillator array consists of a train of pulses, similar to a mode-locked laser. Due to the different physical mechanisms involved, and due to a spatial as well as spectral separation of the oscillators, the mode-locked array exhibits new phenomena not present in mode-locked lasers. A theory describing the coupled-oscillator dynamics is developed to explore these new effects, and the theory is amply supported with empirical evidence obtained with a linear array of Gunn diode oscillators operating at 11 GHz.
Understanding attachment and attachment disorders (2007)

Jessica Kingsley Press, London, 2006 Reviewed by Graham Music There is a pleasurable irony in reviewing this book for the Infant Observation Journal. The traditions and disciplines of both infant o...
SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton (2015)

Formin proteins are key regulators of the cytoskeleton involved in developmental and homeostatic programs, and human disease. For these reasons, small molecules interfering with Formins' activity have gained increasing attention. Among them, small molecule inhibitor of Formin Homology 2 domains (SMIFH2) is often used as a pharmacological Formin blocker. Although SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton, its cellular mechanism of action and target specificity remain unclear. Here we show that SMIFH2 induces remodelling of actin filaments, microtubules and the Golgi complex as a result of its effects on Formins and p53. We found that SMIFH2 triggers alternated depolymerization-repolymerization cycles of actin and tubulin, increases cell migration, causes scattering of the Golgi complex, and also cytotoxicity at high dose. Moreover, SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton. As the action of SMIFH2 may go beyond Formin inhibition, only short-term and low-dose SMIFH2 treatments minimize confounding effects induced by loss of p53 and cytotoxicity.
Cu(I)/TF-BiphamPhos Catalyzed Reactions of Alkylidene Bisphosphates and Alkylidene Malonates with Azomethine Ylides: Michael Addition versus 1,3-Dipolar Cycloaddition (2012)

Cu(I)/TF-BiphamPhos catalyzed reactions of alkylidene bisphosphates and alkylidene malonates with azomethine ylides have been investigated with the aid of density functional theory calculations at the B3LYP level. Michael addition and 1,3-dipolar cycloaddition were calculated. For reactions of alkylidene bisphosphates, the Michael addition pathway is both kinetically and thermodynamically more favorable than 1,3-dipolar cycloaddition. However, for reactions of alkylidene malonates, the 1,3-dipolar cycloaddition pathway is kinetically and thermodynamically more favorable than Michael addition. In the reactions of alkylidene bisphosphates, the significant repulsion between the two bulky phosphonate groups of the alkylidene bisphosphates and the phenyl substituent of the azomethine ylides suppresses 1,3-dipolar cycloaddition and favors Michael addition. In the reactions of alkylidene malonates the less bulky ester groups in the alkylidene malonates allow 1,3-dipolar cycloaddition to occur.
Digital Transmission Engineering (2005)

This textbook is a 4th year(Sweden)/5th year (USA) text in digital communication theory and practice. Chapters include baseband pulse transmission, carrier transmission, synchronization, channels, coding and information theory, and advanced topics. Each chapter ends with 25 home exercises. Worked examples and Matlab tools are integrated with the text.
An Algorithm for Determining the Intersection of Two Simple Polyhedra (1984)

Abstract An algorithm is presented for the construction of the intersection of two simple possibly non‐convex polyhedra. The methods of descriptive geometry are applied, so that this three‐dimensional problem can be solved in two dimensions. We have to find all intersections of the edges of each polyhedron with the faces of the other, and these points of intersection can be found in Monge's model. Projecting both polyhedra on the xy and on the xz coordinate planes we obtain two superimposed maps in both projections. The algorithm to find the intersection of two maps is based upon the Shamos‐Hoey, the Bentley‐Ottmann and the Nievergelt‐Preparata algorithms. The asymptotic time requirement for determining the polygon of intersection of two polyhedra is O((N + S)log N) , where N is the sum of the numbers of vertices of the two polyhedra and S is the total number of intersections of all projected edges in the xy‐plane ( S = O(N 2 )).
Direct Face-to-Face Communication Between Real and Virtual Humans (2015)

Interaction in graphical systems is becoming more and more multimodal. Use of the conventional mode of 2D widget-mouse or keyboard interaction is not very natural for many applications. For the comfort of disabled persons who may not be able to use the hand input devices, it is necessary to explore means for interactive controls for them. In this paper, we discuss real time interaction through facial input and face-to-face communication in a virtual dialog. The paper presents our method of extracting dynamic facial movements which can be hooked as controls for a desired application. For example, in performance driven facial animation, the method enables recognition of facial expressions of a real person which are appropriately mapped as controlling parameters to simulate facial expressions of a synthetic actor in real time. In other applications, the extracted parameters can provide real time estimates of positions and orientations in a virtual scene. The method requires a video camera input and extracts motion parameters through a small set of visually tracked feature points. In the face-to-face virtual dialog, recognition acts like a module for acquiring emotional states of a real actor. This can be integrated with other modules for the interpretation of the response with voice and emotions of the virtual actor. This gives potential for an interface system with human like agent interacting with user in spoken language with facial expressions.
Characteristics of clay minerals of montmorillonites in the wet state. (1989)

モンモリロナイト系粘土鉱物を水中の有機物の吸着除去などに利用するための基礎研究として, モンモリロナイト, ベントナイト, 酸性白土, 活性白土など5種類の粘土鉱物について, 湿潤状態での性状を調べ, 乾燥状態と比較検討した。湿潤状態における粒径と表面形態を電子顕微鏡を用いて調べたところ, 層間イオンが Ca や H の水中膨潤性の小さいものは平均直径が数 μm の粒子になったが, 層間イオンがNaの水中膨潤牲の大きいものは数百Å以下の微結晶まで分散した。湿潤状態における結晶底面間隔をX線回折法で測定したところ, いずれも従来の報告とほぼ同じ約20Åとなることが確認された。湿潤状態における細孔分布と比表面積を水蒸気吸着等温線から求めたところ, 直径100Å以下の細孔容積は 240～340mm3/g となり, 窒素吸着等温線から求めた乾燥状態の細孔容積にくらべて 2.3～13 倍に増えた。また, 比表面積は 300～450m2/g となり, 乾燥状態にくらべて 2.3～28 倍に増えた。なお, 円筒モデルおよび平行板モデルによる細孔分布の計算結果から両モデルの間に本質的な差異がないことがわかった。
Treatment of Postmenopausal Osteoporosis (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tunable mechanical resonator with aluminium nitride piezoelectric actuation (2006)

The electromechanical response of piezoelectrically-actuated AlN micromachined bridge resonators has been characterized using laser interferometry and electrical admittance measurements. We compare the response of microbridges with different dimensions and buckling (induced by the initial residual stress of the layers). The resonance frequencies are in good agreement with numerical simulations of the electromechanical behavior of the structures. We show that it is possible to perform a rough tuning of the resonance frequencies by allowing a determined amount of built-in stress in the microbridge during its fabrication. Once the resonator is made, a DC bias added to the AC excitation signal allows to fine-tune the frequency. Our microbridges yield a tuning factor of around 88 Hz/V for a 500 μm-long microbridge.
Blood group incidence and <i>Escherichia coli</i> bacterial sepsis (1986)

Many strains of Escherichia coli possess an antigen that reacts with naturally occurring antibodies to human red cell B antigens. The authors tested the hypothesis that the presence of naturally occurring anti-B isoagglutinins afford protection against the development of E. coli septicemia. The blood groups found in 115 patients with E. coli septicemia were compared with those found in three "control" populations: 138 patients with septicemia due to other organisms, 23,135 hospitalized patients, and 40,038 normal blood donors. The relative incidence of B and AB blood groups (not containing anti-B antibodies) was significantly higher than A and O blood groups (containing anti-B antibodies) in the group with E. coli septicemia. This finding supports the hypothesis.
Immunotoxins: the potential in cancer treatment. (1990)

Since its development in 1975, monoclonal antibody (mAb) technology has greatly enhanced our ability to analyse complex antigenic systems as well as improve the sensitivity and speed of many diagnostic tests. In particular, the study of tumour associated antigens using mAbs have revealed that many transformed cell phenotypes have useful markers on their plasma membrane, cytoplasm, or as secreted forms which can be used in developing diagnostic assays. Therapeutic application of these anti-tumour mAbs has however, been slow relative to the research and diagnostic applications. This article will discuss how the therapeutic effectiveness of anti-tumour mAbs can be enhanced by coupling them to drugs, toxins or radionucleids; and review the current advances and problems related to the application of these mAb conjugates.