gebhart/patrepeval huggingface dataset:
Analysis of cloned T cell function. I. Dissection of cloned T cell proliferative responses using cyclosporin A. (1982)

CsA interferes in a specific manner with the expansion of T cell clones in that it inhibits the antigen-driven component of the proliferative responses made by cloned helper T cells, cloned conventional cytolytic T cells, and cloned helper-independent cytolytic T cells. Cloned helper T cells and helper-independent cytolytic T cells, which share the ability to proliferate when cultured with specific alloantigen, fail to proliferate when cultured with specific alloantigen, fail to proliferate in response to this stimulus in the presence of CsA (10 to 100 ng/ml). In contrast, the proliferation observed when these cells are cultured with exogenous growth factors (but not alloantigen) is little influenced by as much as 1000 ng/ml CsA. When cloned helper T cells or helper-independent cytotoxic T cells are cultured with alloantigen plus exogenous growth factor, additive or synergistic proliferation occurs. However, CsA (10 to 1000 ng/ml) blocks only the component of proliferation induced by alloantigen, and leaves the lymphokine-driven component intact. CsA has similar effects on the proliferation of cloned conventional cytolytic T cells. Thus, CsA separates cloned T cell proliferation into two components: one driven by contact with alloantigens, the other driven by contact with mitogenic lymphokines.
Graphics Processing Units for Handhelds In handheld devices that display 3-D images, lower-power consumption for graphics hardware can be achieved by algorithms that reduce bus traffic with system memory and provide more efficient rendering. (2008)

Duringthe past few years, mobilephones andother handheld devices have gone from only handling dull text-based menu systems to, on an increasing number of models, being able to render high-quality three-dimensional graphics at high frame rates. This paper is a survey of the special considerations that must be taken when designing graphics processing units (GPUs) on such devices. Starting off by introducing desktop GPUs as a reference, the paper discusses how mobile GPUs are designed, often with power consumption rather than performance as the primary goal. Lowering the bus traffic between the GPU and the memory is an efficient way of reducing power consumption, and therefore some high-level algorithms for bandwidth reduction are presented. In addition, an overview of the different APIs that are used in the handheld market to handle both two-dimensional and three-dimensional graphics is provided. Finally, we present our outlook for the future and discuss directions of future research on handheld GPUs.
Radioimmunoassay for human corticosteroid-binding globulin. (1983)

Abstract We isolated corticosteroid-binding globulin from human plasma and used the isolated protein as the antigen in raising antibodies in rabbits. The resulting antiserum was used to develop an RIA with which we can determine the globulin in as little as 0.007 microL of serum, although we routinely use, after appropriate dilution, 0.02 microL. The mean concentration of corticosteroid-binding globulin in the serum of 40 normal subjects was 32.4 (SD 4.2) mg/L. The correlation (r) between results with this RIA and those by an established binding assay was 0.94.
Core temperature affects scalp skin temperature during scalp cooling (2015)

Slight cooling of patients with an elevated body temperature during scalp cooling contributes to the decrease in scalp temperature and may improve the prevention of hair loss. This may be useful if the desired decrease of scalp temperature cannot be obtained by scalp cooling systems.
Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture (2019)

Epidermal homeostasis depends on a balance between self-renewal of stem cells and terminal differentiation of their progeny. Notch signalling is known to play a role in epidermal stem cell patterning and differentiation. However, the molecular mechanisms are incompletely understood. Here we demonstrate dynamic patterns of Notch ligand and receptor expression in cultured human epidermis. Notch2 and 3 act together to promote differentiation, while Notch1 decreases stem cell proliferation. The Notch ligand Jagged1 triggers differentiation when presented on an adhesive substrate or on polystyrene beads and over-rides the differentiation inhibitory effect of cell spreading. In contrast, Delta-like 1 (Dll1) overexpression abrogates the pro-differentiation effect of Jagged1 in a cell autonomous fashion. We conclude that Dll1 expression by stem cells not only stimulates differentiation of neighbouring cells in trans, but also inhibits differentiation cell autonomously. These results highlight the distinct roles of different Notch receptors and ligands in controlling epidermal homeostasis.
LCC, a cerebroside from Lycium chinense, protects primary cultured rat hepatocytes exposed to galactosamine (2000)

Primary cultures of rat hepatocytes exposed to galactosamine (GalN) were used as a screening system to assess whether a new cerebroside, LCC, isolated from the fruits of Lycium chinense, exhibits hepatoprotective activity. Cultured rat hepatocytes injured with GalN routinely release glutamic pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) into the culture medium. Treatment of these GalN-injured primary cultures with LCC markedly blocked the release of both GPT and SDH in a dose-dependent manner over concentrations of LCC ranging from 1 microM to 10 microM. To investigate the mechanism of action for the hepatoprotective activity of LCC, the extent of [(3)H]-uridine incorporation into RNA was measured in GalN-injured cultures of rat hepatocytes. [(3)H]-Uridine incorporation was significantly decreased in injured hepatocytes. LCC, however significantly restored the incorporation of [(3)H]-uridine into RNA in a dose-dependent manner over concentrations ranging from 1 microM to 10 microM. LCC also blocked the suppression of RNA synthesis caused by actinomycin D in a dose-dependent manner. These data suggest that LCC may have prominent hepatoprotective activity and that its therapeutic value should be investigated further.
Influence of Interfacial Constraints on the Morphology of Asymmetric Crystalline-Amorphous Diblock Copolymer Films (2005)

Through control of the temperature, T, and film thickness, h, the relative influence of forces associated with crystallization, long-range van der Waals forces, and block-copolymer ordering were manipulated to control the structure of films of asymmetric polyethylene-b-poly(styrene-r-ethylene-r-butene) (E-b-SEB) diblock copolymers. The bulk equilibrium structure of this copolymer consists of spheres of the crystallizable E block embedded in the amorphous SEB matrix. In thin films, the E component resides at the free surface and the SEB block resides in contact with the substrate. Within the temperature range T > Tm, where Tm is the melting temperature, yet below the order−disorder transition (ODT) temperature, TODT, all films of thickness h > 12 nm were ordered throughout. The thickness of the brush layer L0, in contact with the substrate, of these films was 12 nm; this thickness is about one-half of the intersphere spacing of the bulk copolymer. Films equal to or thinner than 12 nm dewet, forming droplets on the substrate. However, at temperatures below the melting temperature but above the glass transition temperature of the amorphous block, films in the same thickness range (h ≤ 12 nm) were structurally stable. While thicker films were stable as well, crystallization had a significant effect on the topography of these films, particularly as the film thickness increased.
A small field of view camera for hybrid gamma and optical imaging (2014)

The development of compact low profile gamma-ray detectors has allowed the production of small field of view, hand held imaging devices for use at the patient bedside and in operating theatres. The combination of an optical and a gamma camera, in a co-aligned configuration, offers high spatial resolution multi-modal imaging giving a superimposed scintigraphic and optical image. This innovative introduction of hybrid imaging offers new possibilities for assisting surgeons in localising the site of uptake in procedures such as sentinel node detection. Recent improvements to the camera system along with results of phantom and clinical imaging are reported.
Some Distinguishing Features about Citizenship Education in Hong Kong Schools (2001)

In the long course of Hong Kongs social citizenship education, the theory and policy frame and development of such education is not only distinguishing component in citizenship education of the world,but also can be well used as a good short distance reference for Chinas education reform.
Effect of expandable and expanded graphites on the thermo-mechanical properties of polyamide 11 (2018)

The preparation and thermo-mechanical characterization of composites based on polyamide 11 (PA11) filled with various amounts of both expandable and expanded graphites are presented. Investigation conducted using X-ray diffraction (XRD), scanning electron microscopy and surface area analyses indicated how graphite expanded under the selected processing conditions. The XRD analysis on PA11/graphite composites revealed no change in the crystal form of the PA11, while the presence of diffraction peaks associated to the graphite-stacked lamellae can be still detected. All the investigated composites showed an improvement of the thermal stability and mechanical properties (elastic and storage moduli).
Testattu tieto auttaa valitsemaan porkkanalajikkeen (2012)

Pitkään viljelyssä olleen varastoporkkana Fontanan rinnalle on nousemassa uutuuslajikkeita. Luomuviljelyssä Maestro pitää edelleen pintansa. Lajiketestauksilla saadaan seulottua laajasta porkkananlajikekirjosta viljelyoloihimme ja eri tuotantosuuntiin soveltuvat lajikkeet.
Gait Abnormalities in Elderly Fallers (2003)

The objective of this study was to measure gait abnormalities in elderly fallers with the Locometrix™ gait-analysis system. This accelerometric device provided the following gait variables: walking speed and stride frequency, length, symmetry, and regularity. The variables were analyzed over a 20-s period of stable walking on a flat track of 40 m. Participants were 20 elderly patients hospitalized for falls (mean age 80.8 ± 5.0 years) and 33 older adults living at home (mean age 77.2 ± 6.5 years). All gait variables were found to be significantly lower in the faller group ( p < .05). The lower gait speed, stride length, and stride frequency were previously recognized as nonrelevant in predicting the risk of falling, whereas lower stride symmetry was related to an underlying pathology and lower stride regularity was correlated to the risk of falls. The Locometrix appears to be well suited to measure gait regularity in routine practice.
De novo synthesis of polyhydroxyl aminocyclohexanes (2010)

The syntheses of 12 stereochemically diverse polyhydroxyl aminocyclohexane ("aminocyclitols") derivatives are described. These short syntheses require 2-5 steps from N-(2,4-cyclohexadien-1-yl)phthalimide, which is prepared in two steps from tricarbonyl(cyclohexadienyl)iron(1+). The relative stereochemistries of the aminocyclitols were assigned by (1)H NMR spectroscopy as well as X-ray diffraction analysis.
Liquid based formulations of bacteriophages for the management of waterborne bacterial pathogens in water microcosms. (2013)

Water resources are contaminated by life-threatening multidrug resistant pathogenic bacteria. Unfortunately, these pathogenic bacteria do not respond to the traditional water purification methods. Therefore, there is a need of environmentally friendly strategies to overcome the problems associated with the antimicrobial resistant bacterial pathogens. In the present study, highly potent lytic phages against multidrug-resistant Salmonella enterica serovar Paratyphi B, Pseudomonas aeruginosa and Klebsiella pneumoniae were isolated from the Pavana river water. They belonged to the Podoviridae and Siphoviridae families. These phages were purified and enriched in the laboratory. Monovalent formulations of phiSPB, BVPaP-3 and KPP phages were prepared in three different liquids viz., phage broth, saline and distilled water. The phages were stable for almost 8-10 months in the phage broth at 4 degrees C. The stability of the phages in saline and distilled water was 5-6 months at 4 degrees C. All of the phages were stable only for 4-6 months in the phage broth at 30 degrees C. The monovalent phage formulation of psiSPB was applied at MOI < 1, as disinfectant against an exponential and stationary phase cells of Salmonella enterica serovar Paratyphi B in various water microcosms. The results indicated that there was almost 80 % reduction in the log phase cells of Salmonella serovar Paratyphi B in 24 h. In stationary phase cells, the reduction was comparatively less within same period. At the same time, there was concomitant increase in the phage population by 80% in all the microcosms indicating that psiSPB phage is highly potent in killing pathogen in water. Results strongly support that the formulation of psiSPB in the phage broth in monovalent form could be used as an effective biological disinfectant for preventing transmission of water-borne bacterial pathogens, including antimicrobial resistant ones.
Development of the Subtle ADHD Malingering Screener (2018)

The objective of this study was to develop a subtle self-report scale-the Subtle ADHD Malingering Screener (SAMS)-to screen for malingering among individuals reporting symptoms of attention deficit/hyperactivity disorder (ADHD). This study employed a cross-sectional experimental design with an ADHD group, a control group-comprising individuals without ADHD-and a malingering group-comprising individuals without ADHD who were instructed to feign ADHD in their responses. Factor analysis and psychometric testing were conducted to develop a final scale that could distinguish the malingering from the other groups. A 10-item, two-factor solution was obtained for the SAMS, with a sensitivity of 90.3% and specificity of 80.1%. The SAMS presents an innovative approach to help reduce overdiagnosis of ADHD and misuse of prescription stimulants. The efficient, straightforward form of the measure particularly enhances its potential application in both medical and psychosocial clinical settings.
ChemInform Abstract: OXYGEN EVOLUTION AND CORROSION ON RUTHENIUM‐IRIDIUM ALLOYS (1985)

Abstract Die Anfangsstadien der OQ‐Entwicklung sowie der anodischen Korrosion an Ru‐lr‐Legierungen (hergestellt durch gemischte HF‐Aufstäubung auf Glassubstrate) werden in l N H280′ durch Voltammetrie und Photoelektronenspektroskopie untersucht.
Identification of sequence elements regulating promoter activity and replication of a monopartite begomovirus-associated DNA   satellite (2008)

DNA beta is a circular single-stranded satellite DNA associated with certain monopartite begomoviruses (family Geminiviridae) which causes economically important diseases such as cotton leaf curl disease. DNA beta contains a single gene, betaC1, which encodes a pathogenicity protein responsible for symptom production. Transient expression studies in Nicotiana tabacum using the beta-glucuronidase reporter gene driven by a betaC1 promoter-deletion series of the DNA beta associated with cotton leaf curl Multan virus identified a 68 nt region (between -139 and -207) which is important for betaC1 transcription. This 68 nt region contains a G-box (CACGTG) located 143 nt upstream of the betaC1 start codon. Mutation of the G-box resulted in a significant reduction in betaC1 promoter activity and DNA beta replication efficiency. In addition, the G-box motif was found to bind specifically to a protein(s) in nuclear extracts prepared from tobacco leaf tissues. Our results indicate that interaction of the G-box motif with host nuclear factors is important for efficient gene expression and replication of DNA beta.
Zur Keto‐Enol‐Tautomerie bei heterocyclischen β‐Ketocarbonsäureestern 3. Mitt.: Konfiguration und Konformation 2,6‐dialkylsubstituierter β‐Ketodicarbonsäureester (1969)

Abstract An Hand der 1 H‐NMR‐Spektren wurde die Konfiguration und Konformation von 1‐Aza‐, 1‐Oxa‐, 1‐Thia‐ und 1‐Selenacyclohexanondicarbonsäureestern untersucht. In den Ketoformen dieser Verbindungen weisen die Substituenten an C‐2, ‐3, ‐5 und ‐6 die relative Konfiguration 2,6‐/3,5‐cis, 2,3‐/5,6‐trans auf. Die bevorzugte Konformation ist die Sesselform mit äquatorialer Stellung aller Substituenten.
ChemInform Abstract: 3‐Aryl‐2,4‐pentanediones from 3,5‐Dimethyl‐4‐iodoisoxazoles: An Application of a Palladium‐Catalyzed Cross‐Coupling Reaction. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Over‐expression of a novel nuclear interactor of Suppressor of fused, the <i>Drosophila</i> myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis (2003)

We propose that dSu(fu) and dMLF act together at the transcriptional level to coordinate patterning and proliferation during development.
THA—A Review of the Literature and Its Use in Treatment of Five Overdose Patients (1980)

(1980). THA—A Review of the Literature and Its Use in Treatment of Five Overdose Patients. Clinical Toxicology: Vol. 16, No. 3, pp. 269-281.
Inner Complexes of Uranium Containing 1,3-Dicarbonyl Chelating Groups (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInner Complexes of Uranium Containing 1,3-Dicarbonyl Chelating GroupsH. I. Schlesinger, Herbert C. Brown, J. J. Katz, S. Archer, and R. A. LadCite this: J. Am. Chem. Soc. 1953, 75, 10, 2446–2448Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/ja01106a050https://doi.org/10.1021/ja01106a050research-articleACS PublicationsRequest reuse permissionsArticle Views291Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pathophysiology of Chest Pain in Patients With Nutcracker Esophagus (2001)

Patients with a nutcracker esophagus demonstrate a hypersensitive and stiff esophagus. Because balloon distention reproduced their chest pain, visceral hyperalgesia of the esophagus may be relevant to the pathogenesis of their pain. Balloon distention test may be more useful in the evaluation of patients with functional chest pain and a nutcracker esophagus.
Multi-variate block polar quantization and an application to audio (2004)

We introduce multi-variate block polar quantization (MBPQ). MBPQ minimizes a weighted distortion for a set of complex variables representing one block of a signal under a resolution constraint for the entire block. MBPQ allows for different probability distributions in different dimensions of the set of complex variables. It outperforms a block polar quantizer introduced earlier (Pobloth, H. et al., Proc. Eurospeech, p.1097-100, 2003), and unrestricted polar quantization (UPQ), for both Gaussian complex variables and sinusoids found from audio data. In the case of audio data, we found a performance gain of about 2.5 dB over the best performing conventional resolution-constrained polar quantization, UPQ.
АНАЛИЗ ГЕНОТИПИЧЕСКОЙ ЗАВИСИМОСТИ ЧАСТОТ ХРОМОСОМНЫХ АБЕРРАЦИЙ В ЛИМФОЦИТАХ ЧЕЛОВЕКА ПРИ ОБЛУЧЕНИИ IN VIVO И IN VITRO (2010)

Представлены данные по изменчивости повышенного уровня частот хромосомных аберраций для группы ликвидаторов аварии на ЧАЭС в зависимости от генотипов по кандидатным локусам. Генотипирование проводилось по сайтам, которые ранее обнаруживали ассоциации с цитогенетической изменчивостью в контрольных экспериментах. Показано, что для группы ликвидаторов, гетерозиготных по сайту SOD2 C47T, частота хромосомных аберраций значимо не превышает контрольный уровень. На уровне тенденции частота аберраций у ликвидаторов была понижена для двойных гомозигот по делециям генов GSTM1-GSTT1 и гомозигот по минорному аллелю сайта CYP1A1 T606G, что соответствовало результатам экспериментов с контрольной выборкой. В целом повышенный уровень хромосомных аберраций у ликвидаторов наблюдается для тех генотипов, которые демонстрируют повышенный уровень спонтанных аберраций, и не вполне соответствует генотипам с повышенной радиочувствительностью хромосом.
Bromination of indomethacin (2010)

Treatment of indomethacin with N-bromosuccinimide in AcOH results in bromination in aromatic positions 4 and 6, while the use of tetrachloromethane allows ultimate bromination at the C(2) Me group of the indole moiety to proceed.
Gene Structure, Promoter Characterization, and Basis for Alternative mRNA Splicing of the Human <i>CD58</i> Gene (1998)

The 60-kDa lymphocyte function-associated Ag-3 (LFA-3/CD58), a highly glycosylated adhesion molecule that serves as ligand for the T cell-restricted glycoprotein CD2, is encoded by a gene at the human chromosome locus 1p13. We have elucidated the exon-intron organization of the entire human CD58 gene, including approximately 2.5 kilobases (kb) of 5'-flanking DNA. Four overlapping genomic clones, spanning approximately 65 kb, contained the entire approximately 1-kb coding sequence of CD58 and consisted of six separate exons, which varied from 72 to 294 bp in size. At least two different CD58 mRNA precursors can be generated from the human gene as a result of alternative choice of one of the two acceptor splice sites located within exon 5. DNA sequence analysis of about 2.5 kb of 5'-flanking sequence of the CD58 gene indicated the absence of a CAAT box. However, potential binding sites for the transcriptional activators AP-2, GATA, PU.1, and Sp-1 are present. Two consensus TATAA elements, located approximately 2.4 kb upstream of the transcriptional start site, have been identified. The 2.5-kb CD58 promoter sequence displayed functional activity in transient transfection assays in the hepatocellular carcinoma cell line HepG2. Comparing the response of CD58 promoter-driven luciferase plasmids to several cytokines and other agents suggests that the CD58 promoter is regulated by up-regulatory, enhancer-like and down-regulatory, silencer-like elements. Further analysis of this region should allow researchers to gain insight into the molecular mechanisms by which this gene is regulated, e.g., during inflammatory responses.