gebhart/patrepeval huggingface dataset:
THE INCREASE IN THE TOXICITY OF YOHIMBINE INDUCED BY IMIPRAMINE AND OTHER DRUGS IN MICE (1963)

In mice, yohimbine appears to accentuate the normal "alarm" reactions (alerting, flight) to external stimuli. Imipramine increases this effect and at the same time converts a non-lethal dose of yohimbine into a lethal one. The effect of imipramine is greatly reduced by adrenalectomy or by treatment with reserpine, syrosingopine, ganglion-blocking drugs or adrenaline antagonists acting on sympathetic beta-receptors. Hypnotic, anti-convulsant or anaesthetic agents, tetrabenazine or antagonists of 5-hydroxytryptamine do not reduce the imipramine effect. A variety of drugs which, like imipramine, are known to interfere with the tissue binding of noradrenaline also increase the toxicity of yohimbine. Yohimbine significantly reduces brain noradrenaline content; adrenal catechol amines are slightly reduced. The results suggest that yohimbine releases noradrenaline from stores or nerves as a consequence of increased central sympathetic activity. Imipramine increases the actions and toxicity of yohimbine by increasing the effects of the released noradrenaline on beta-receptors. The lethal effects of a high dose of yohimbine alone are not reduced by any of the treatments tested, and appear not to result from activation of sympathetic mechanisms.
IMGT Unique Numbering for the Variable (V), Constant (C), and Groove (G) Domains of IG, TR, MH, IgSF, and MhSF (2011)

INTRODUCTION The “IMGT unique numbering” (or “IMGT_unique_numbering”) concept is a major concept of numerotation (generated from the NUMEROTATION axiom) of IMGT-ONTOLOGY, the global reference in immunogenetics and immunoinformatics, built by IMGT, the international ImMunoGeneTics information system. The “IMGT unique numbering” concept, described here, allows one to number domain types that are characteristic of protein superfamilies, whatever the species, the molecule type or the chain type. Three leafconcepts (a leafconcept is a concept that corresponds to the finest level of granularity) have been defined, respectively, for the variable (V) domain and constant (C) domain of the immunoglobulin superfamily (IgSF) and for the groove (G) domain of the major histocompatibility (MH) superfamily (MhSF). The IMGT unique numbering concept has been a great breakthrough in immunogenetics and systems biology in allowing, for the first time, the bridging of the gap between amino acid (and nucleotide) sequences of any V, C, or G domain and their two-dimensional (2D) and three-dimensional (3D) structures. The IMGT unique numbering concept has been fundamental in the creation of the IMGT Collier de Perles and in the standardization of the description of mutations, amino acid changes, polymorphisms, and contact analysis in the IMGT databases, tools, and web resources.
Fatigue crack growth and threshold measurements at very high frequencies (1999)

Fatigue testing at ultrasonic frequencies makes it possible to investigate the fatigue properties of materials in an effective and time saving manner. The mechanical and electrical components of ultrasound equipment are described in detail. Different testing and evaluation procedures are reviewed. Recommendations on how to perform high frequency fracture mechanics studies and to evaluate experimental results are described. Recent developments for multiaxial loading, for performing in-service loading fatigue experiments, and for realising high frequency torsional vibrations are described. A survey of fatigue investigations of metallic materials, composites, metallic glass, and ceramics, determined with the ultrasound method, is presented. Intrinsic frequency effects are reviewed, emphasising the influences on dislocation structures, crack initiation, and fatigue crack growth for pure metals and for technical materials. The advantages and disadvantages of the ultrasound method are compared with those of conventional fatigue testing equipment.
Fuzzy Trust Inference in Trust Graphs and its Application in Semantic Web Social Networks (2006)

People generate information or get it from the others. When one gets information from the others it is important to get it from trusted ones. Each individual in a society can get the information he needs form his trusted friends but there are also many other people in the society that he or she indirectly trusts and can benefit from their information. The idea of benefiting from the indirectly trusted people can well be employed in social networks where finding trusted people can be automated. There should be a feature for users to specify how much they trust a friend and a mechanism to infer the trust in the society trust graph from one user to another that is not directly a friend of the user so that a recommender site can benefit from these inferred trust ratings for showing trustworthy information to each user from her or his point of view from not only her or his directly trusted friends but also the other indirectly trusted users. A problem that is faced in inference in such a large network is contradictory information. This work suggests using fuzzy linguistic terms to specify trust to other users and proposes an algorithm for inferring trust from a person to another person that may be not directly connected in the trust graph of a social network. The algorithm is implemented and compared to the previous one that models trust as numbers in a range. While according to the imprecise nature of trust concept, writing and reading a linguistic expression for trust is much more natural than a number for users, the fuzzy composing strategy performs better than the previous algorithm in integrating conflicting beliefs and conveying the conflict in the inferred result.
Time-Cost Optimization of Construction Projects with Generalized Activity Constraints (2005)

Time-cost analysis is an important element of project scheduling, especially for lengthy and costly construction projects, as it evaluates alternative schedules and establishes an optimum one considering any project completion deadline. Existing methods for time-cost analysis have not adequately considered typical activity and project characteristics, such as generalized precedence relationships between activities, external time constraints, activity planning constraints, and bonuses/penalties for early/delayed project completion that would provide a more realistic representation of actual construction projects. The present work aims to incorporate such characteristics in the analysis and has developed two solution methods, an exact and an approximate one. The exact method utilizes a linear/integer programming model to provide the optimal project time-cost curve and the minimum cost schedule considering all activity time-cost alternatives together. The approximate method performs a progressive project length reduction providing a near-optimal project time-cost curve but it is faster than the exact method as it examines only certain activities at each stage. In addition, it can be easily incorporated in project scheduling software. Evaluation results indicate that both methods can effectively simulate the structure of construction projects, and their application is expected to provide time and cost savings.
A New Energy-Efficient Time Synchronization Protocol in Wireless Sensor Networks (2014)

In some time critical Wireless Sensor Networks (WSN), time synchronization is crucial in the working process. Due to the limitations of WSN, such as the equipment dimension, the computing power, the data storage and energy capacity of the node, there are some special requirements for the time synchronization scheme, including synchronization accuracy, protocol overhead, and energy efficiency. During the past ten years, many researchers have investigated the time synchronization in WSN, and proposed numerous time synchronization protocols. However, most of the protocols are engaged in how to improve time synchronization accuracy, without regard to the energy consumption. PBS (Pair-wise Broadcast Synchronization), a low-power and fast synchronization protocol, utilizes very little message exchange to make all slave nodes synchronize within a single hop. In this paper, an energy efficient protocol is put forward on the basis of PBS, dubbed IPBS (Improved Pair-wise Broadcast Synchronization), which uses little extra message exchange to extend time synchronization of the slave nodes to two hops with high accuracy.
Cancer-associated SCM-recognition, immunedefense suppression, and serine protease protection peptide. Part I. Isolation, amino acid sequence, homology, and origin. (1992)

The isolation of a cancer-associated, SCM-recognition, immunedefense-suppressing, and serine protease-protecting (CRISPP) peptide from the blood plasma of cancer patients is described. The amino acid sequences were determined on preparations from 12 different cancers. The peptide is composed in 9 cancers of 29 and in 3 cancers of 35 amino acid residues with molecular weights of 3410 and 4007 Da, respectively. A consensus, synthetic 29 amino acid CRISPP peptide (CRISPPs) has the same cancer SCM-recognition (CR) activity and SCM-response modifying effects as the natural peptide. The "cancer SCM-recognition epitope" of the CRISPP peptide was determined. Anti-CRISPPs antibodies were raised and used in immunoassays to confirm the presence of the CRISPP peptides in cancer blood plasmas, in supernatants of cancer cell growth media and in cultured human cancer cells. The amino terminal end sequences of peptides isolated from growth media of cultured breast and colon cancer cells corresponded to amino acid sequences of CRISPP peptides isolated from cancer blood plasmas of subjects with the respective cancers. The CRISPP peptides are between 83 to 100% homologous to the alpha 1-protease inhibitor amino acid sequence located at the carboxy terminal end between residues 358 and 393. The genetic origin of the CRISPP peptides and their selective advantage to cancer cell survival are discussed.
Simulation of flow around piers (2002)

Abstract FLUENT CFD was used to predict the three-dimensional flow field around a circular cylinder. Solutions were obtained for rigid beds and for scour holes of different sizes resulting from different time-durations. The numerical results were used to obtain the variation of bed shear-stress around the cylinder. These results were used in the sediment continuity equation to obtain an expression for the variation of scour depth with time. The asymptotic scour depth was found to depend on three dimensionless numbers: the pile number, the sediment size number and the duration time number. The theoretical relationship was calibrated using various laboratory and field results.
Micro-payment mechanism and improved analysis based on Pay Word (2012)

This paper surveys the micro-payment system of electronic payment based on Pay Word. Pay Word protocol is concretely analyzed and the advantages and disadvantages of this protocol are pointed out. Some representative improved protocols based on Pay Word are detailed classified according to the improved aspect. Finally, this paper gives a discussion on the problem in this field and the future research directions.
Comparative Analysis of the Development of Swarming Communities of<i>Bacillus subtilis</i>168 and a Natural Wild Type: Critical Effects of Surfactin and the Composition of the Medium (2004)

The natural wild-type Bacillus subtilis strain 3610 swarms rapidly on the synthetic B medium in symmetrical concentric waves of branched dendritic patterns. In a comparison of the behavior of the laboratory strain 168 (trp) on different media with that of 3610, strain 168 (trp), which does not produce surfactin, displayed less swarming activity, both qualitatively (pattern formation) and in speed of colonization. On E and B media, 168 failed to swarm; however, with the latter, swarming was arrested at an early stage of development, with filamentous cells and rafts of cells (characteristic of dendrites of 3610) associated with bud-like structures surrounding the central inoculum. In contrast, strain 168 apparently swarmed efficiently on Luria-Bertani (LB) agar, colonizing the entire plate in 24 h. However, analysis of the intermediate stages of development of swarms on LB medium demonstrated that, in comparison with strain 3610, initiation of swarming of 168 (trp) was delayed and the greatly reduced rate of expansion of the swarm was uncoordinated, with some regions advancing faster than others. Moreover, while early stages of swarming in 3610 are accompanied by the formation of large numbers of dendrites whose rapid advance involves packs of cells at the tips, strain 168 advanced more slowly as a continuous front. When sfp+ was inserted into the chromosome of 168 (trp) to reestablish surfactin production, many features observed with 3610 on LB medium were now visible with 168. However, swarming of 168 (sfp+) still showed some reduced speed and a distinctive pattern compared to swarming of 3610. The results are discussed in terms of the possible role of surfactin in the swarming process and the different modes of swarming on LB medium.
Cloud Service Optimization Method for Multi-cloud Brokering (2015)

Cloud brokering facilitates Cloud Service Users (CSUs) to find cloud services according to their requirements. In the current practice, Cloud Service Broker (CSB) selects the cloud services from multi-cloud environment according to Service Level Agreement (SLA) offered by Cloud Service Providers (CSPs). Difficulty in selecting cloud services from multiple CSPs is, there is no guarantee that CSPs deliver cloud services according to SLA offer. In our observation, it is found that most of the CSPs do not fulfill the service commitment mentioned in SLA agreement. It is necessary to be ensured that CSPs are delivering cloud services according to SLA commitment before recommending the cloud services to the CSUs. In this work, we propose a selection method to the CSUs considering both SLA commitment and service delivery by CSPs. As CSUs' requirements are independent to each other and different like minimum Cost for services, high Availability, high Performance, high Security etc., there is not a single optimum solution and there is not a single objective. To provide the best cloud services according to CSUs' requirements, we propose Pareto solutions that consider multiple criteria to provide the optimum set of solutions to the CSUs from multiple CSPs.
A clinical and urodynamic assessment of the Burch colposuspension for genuine stress incontinence (1983)

Twenty-five women having a Burch colposuspension operation were assessed before and after the operation by urodynamic investigations including urethral pressure measurements at rest and on stress. After 3 months, the objective cure rate was 88%. An increase in voiding difficulty and urodynamic evidence of outflow obstruction was seen after the operation. The operation does not induce any significant change in resting urethral profile variables. The stress profile showed accentuation in pressure transmission ratios, most marked in the proximal urethra. These changes are likely to be mechanical in origin and may be responsible for voiding difficulties in those women who initiate voiding by straining.
GRAPHICS PERFORMANCE BENCHMARKING OF ANDROID DEVICES USING OPENGL ES (2015)

As the variety of mobile Android devices available on the market continues to increase and the popularity of mobile games and visually impressive apps also increase, the need arises for a way to analyze the graphical capabilities of the devices on the market in order to continue pushing the limits and producing the next generation of games and apps.The purpose of this thesis paper is to provide an understanding of the graphical capabilities of current Android OS based mobile devices through performance benchmarking using a customizable benchmarking solution.An Android application called "MOBILESpeed" will be developed to be used for benchmarking using scene decomposition which will allow for better analysis and identification of performance bottlenecks.This application will serve to analyze a device's graphical performance through predefined and customizable benchmark test scenes.This thesis will describe the concept of benchmarking, provide information on mobile graphics hardware and architecture, explain the fundamentals and features of OpenGL ES, and also present in detail the tools and methods used to produce the xiv MOBILESpeed benchmarking application from design to implementation.Lastly, a range of devices will be benchmarked and analyzed using MOBILESpeed.The purpose of MOBILESpeed is to provide objective graphical performance data for Android devices so that those looking to acquire a device for graphically intensive applications such as gaming can make a more informed choice.
ECGs by Example (1998)

SECTION 1 SUPRAVENTRICULAR RHYTHMS: Normal Sinus Rhythm. Sinus Arrhythmia (Irregular Sinus Rhythm). Sinus Bradycardia. Sinus Tachycardia. Atrial Fibrillation. Atrial Fibrillation with Rapid Ventricular Response. Atrial Flutter. Atrial Flutter with 2:1 AV Block. Ectopic Atrial Rhythm. Multifocal Atrial Tachycardia. Junctional Bradycardia. Paroxysmal SVT. AV Nodal Re-Entry Tachycardia. Paroxysmal SVT. AV Reciprocating Tachycardia (Orthodromic). AV Reciprocating Tachycardia (Antidromic). Wolff-Parkinson-White Syndrome with Atrial Fibrillation. Supraventricular Tachycardia with Aberrant Conduction. Sick Sinus Syndrome SECTION 2 VENTRICULAR RHYTHMS: Ventricular Premature Beat (VPB). Ventricular Bigeminy. Accelerated Idioventricular Rhythm. Ventricular Tachycardia. Atrio-Ventricular Dissociation /Ventricular Tachycardia. Capture and Fusion Beats. Ventricular Tachycardia. Morphology of VPB. Polymorphic Ventricular Tachycardia. Polymorphic Ventricular Tachycardia. 'Torsade De Pointes. Ventricular Flutter. Ventricular Fibrillation. VF SECTION 3 BUNDLE BRANCH BLOCK: Right Bundle Branch Block. RBBB. Incomplete Right Bundle Branch Block. Left Bundle Branch Block. LBBB. Incomplete Left Bundle Branch Block. Left Anterior Hemiblock. Left Posterior Hemiblock. Right Bundle Branch Block with Left Anterior Hemiblock (Bifasicular Block). Phasic Aberrant Ventricular Conduction SECTION 4 HEART BLOCK: First Degree Heart Block. Second Degree Heart Block (Mobitz 1 or Wenckebach AV Block). Second Degree Heart Block (Mobitz Type 2). Second Degree Heart Block (2:1 AV Block). Second Degree Heart Block (High Grade). Third Degree Heart Block (Wide Complex Escape). Third Degree Heart Block (Narrow Complex Escape). Third Degree Heart Block and Atrial Fibrillation SECTION 5 PACEMAKERS: Ventricular Pacing. Dual Chamber Pacing. Problems with Pacemakers (Failure to Sense). Problems with Pacemakers (Failure to Capture) SECTION 6 ISCHAEMIC HEART DISE ASE: Myocardial Ischaemia (ST Depression). Myocardial Ischaemia (T Wave Inversion). Myocardial I
Time Course of Apparent Temperature Effects on Cardiovascular Mortality: A Comparative Study of Beijing, China and Brisbane, Australia (2012)

This comparative study aimed to clarify the different characteristics of time course of apparent temperature and their effect on cardiovascular mortality in Beijing, China, and Brisbane, Australia. The present study used polynomial distributed lag models to explore the lagged effects of apparent temperature on daily cardiovascular mortality up to 27 days in Beijing, China (2005â2009), and Brisbane, Australia (2004â2007). The results show a longer lagged effect on cold days and a shorter lagged effect on hot days. The cut-off points in Beijing and Brisbane were 22â and 27â, respectively. In Beijing, a statistically significant association was observed for lags of 0â3 days and lags of 3â18 days on hot and cold days, respectively. In Brisbane, a significant association was found for lags of 3â4 days and lags of 10â21 days on hot and cold days, respectively. The lagged effects extended longer for cold apparent temperature but were immediate for hot apparent temperature. Though the cut-off point in Brisbane was higher than in Beijing, the population in Beijing was more resistant to high temperature above the cut-off point than the population in Brisbane.
Business process simulation (1999)

Business processes are increasingly recognised as the key to competitive survival. The important opportunities inherent to this invisible economic asset are the foundations of process centred management.
Assessing the image quality of pelvic MR images acquired with a flat couch for radiotherapy treatment planning (2011)

Although the quantitative performance of the coil is affected by the integration of a flat couch top, there is no discernible deterioration of diagnostic image quality, as assessed by two consultant radiologists. Although the flat couch insert moved patients higher in the bore of the scanner, all patients in the study were successfully scanned.
Darstellung von Bi(α‐methylen‐γ‐lactonen) (1977)

Abstract Aus den Diepoxiden 1 , cis ‐ und trans ‐ 5 werden die Bi(α‐methylen‐γ‐lactone) 4 sowie cis ‐ und trans ‐ 7 über die Lactoncarbonsäuren 3a bzw. cis ‐ und trans ‐ 6a dargestellt. Die Umsetzung der Diketone 9, 10 und trans ‐ 20 mit 2‐(Brommethyl)acrylsäureester führt zu Isomerengemischen der Bilactone 7, 14 und 26 . Aus 15 und cis ‐ 20 erhält man mit 8 sowohl die Monolactone 16 bzw. 24a und b als auch die Bilactone trans ‐ 17 und 25 . Aus den Acetalen 11, 18 , cis ‐ und trans ‐ 19 werden mit 8 bei der Aufarbeitung mit NH 4 Cl‐Lösung die Mono(α‐methylen‐γ‐lactone) 12, 21, 23 und 27 erhalten. Durch saure Hydrolyse entstehen die Ketone 13, 22 und 24 .
A Convenient Preparation of 4,4-Dimethoxybutanal by Ozonolysis of 1,5-Cyclooctadiene (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Convenient Preparation of 4,4-Dimethoxybutanal by Ozonolysis of 1,5-CyclooctadienePan Li, Jianwu Wang, and Kang ZhaoView Author Information Department of Chemistry, 29 Washington Place, New York University, New York, New York 10003Cite this: J. Org. Chem. 1998, 63, 9, 3151–3152Publication Date (Web):April 8, 1998Publication History Received9 January 1998Published online8 April 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/jo980049bhttps://doi.org/10.1021/jo980049bbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views371Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Hydrocarbons,Organic reactions,Organic synthesis,Reagents,Redox reactions Get e-Alerts