gebhart/patrepeval huggingface dataset:
Physical interactions of nanoparticles with biological membranes: The observation of nanoscale hole formation (2005)

ADVERTISEMENT RETURN TO ISSUEPREVFeatureNEXTPhysical interactions of nanoparticles with biological membranes: The observation of nanoscale hole formationSeungpyo HongSeungpyo HongMore by Seungpyo Hong, Jessica A. HesslerJessica A. HesslerMore by Jessica A. Hessler, Mark M. Banaszak HollMark M. Banaszak HollMore by Mark M. Banaszak Holl, Pascale LeroueilPascale LeroueilMore by Pascale Leroueil, Almut MeckeAlmut MeckeMore by Almut Mecke, and Bradford G. OrrBradford G. OrrMore by Bradford G. OrrCite this: J. Chem. Health Saf. 2006, 13, 3, 16–20Publication Date (Web):May 1, 2006Publication History Published online1 May 2006Published inissue 1 May 2006https://pubs.acs.org/doi/10.1016/j.chs.2005.09.004https://doi.org/10.1016/j.chs.2005.09.004research-articleACS Publications© 2006 American Chemical SocietyRequest reuse permissionsArticle Views64Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
E-CADHERIN EXPRESSION DOWNREGULATION ELEVATES TUMOROGENIC POTENTIAL OF HUMAN COLON CANCER CELL LINE HCT116 VIA INCREASE IN CANCER STEM CELLS AMOUNT (2016)

Introduction. E-cadherin aberrant expression or complete loss is common for a number of human malignant neoplasms, and can be a launching mechanism of an epithelial-mesenchymal transition. Passing through epithelial-mesenchymal transition could in turn promote to the acquisition of so called cancer stem cell phenotype by the transformed cells. The objective of the present study is to reveal the influence of E-cadherin expression level on the amount of cancer stem cells in human colon cancer cell line HCT116. Materials and methods. We have created cell sublines with E-cadherin up- and downregulation and assessed the percentage of cancer stem cells using tumor formation assay, clonogenic assay; we also evaluated profile of cell pluripotency markers. Results and conclusion. We have shown that the proportion of cancer stem cells in human colon adenocarcinoma cell line HCT116 depends on the E-cadherin expression level. E-cadherin expression downregulation results in elevated expression of pluripotency genes and in the increase of proportion of cancer stem cells via activation of Wnt/ß-signalling pathway. E-cadherin upregulation has a reverse effect and decreases the amount of HCT116 cancer stem cells. Thus, E-cadherin expression restoration seems prospective in colorectal anticancer therapy.
[Light-dependent changes of ribosome distribution in photoreceptor inner segments of the mouse retina]. (1994)

We studied the distribution pattern of free ribosomes in the photoreceptor inner segments of adult mice with reference to environmental light. Eyeballs were obtained from animals at the light or dark phase of the ordinary cyclic light, and photoreceptor inner segments were examined by electron microscopy. In the light phase, free ribosomes were distributed in a random fashion, although meticulous observations revealed that they appeared to be arranged either in a spiral or linear form, or in isolation. In the dark phase, several free ribosomes were arranged in a clustered fashion. When animals were kept in continuous darkness as long as 27 hours, most of the inner segment free ribosomes showed a clustered pattern similar to that in the dark phase of the cyclic light. We discussed the light-dependent configurational changes of ribosomes with respect to their activity or inactivity in protein synthesis.
STUDIES ON INCREASED ACID HYDROLASE ACTIVITIES IN DENERVATED MUSCLE (1977)

Abstract— Denervation of rat hemidiaphragm led to large increases in the activity of acid proteinase, cathepsin B1 and β‐glucuronidase in the muscle. The increases were not confined to the endplate regions of the muscle. Mononuclear cells extracted from normal and denervated extensor digitorum longus and diaphragm muscles contained only a small proportion of the acid proteinase and cathepsin B1 activities in the muscle. Actinomycin D, but not methotrexate, prevented the increase in acid proteinase and cathepsin B1 normally resulting from denervation. Brij/58 increased acid proteinase activity to a smaller extent in the denervated muscle than in the control. The length of the distal nerve stump remaining after denervation influenced the enzyme increases, but acid proteinase and cathepsin B1 appeared to be affected differently. The significance of the post‐denervation increase in hydrolase activities is still unknown.
Data Mining in Higher Education (2011)

Higher Education targets to develop complex theoretical, abstract and analytical reasoning capabilities in the alumni. This objective can be accomplished addressing four major steps: Theoretical foundation, practice, communication and assessment (Petry, 2002). Theoretical background and practical exercise comprise the basic knowledge building process at initial stages. Assessment guides the alumni through higher complexity studies permitting the student to identify the weak points in the knowledge building where further theory study and/or practice is required. Theoretical foundation and problem-solving practice are well known aspects in Higher Education. High-quality materials in printed and electronic format, sometimes including multimedia –audio, video or computer graphics–, sometimes delivered through the Internet are readily available today. Teaching-aids as computer-feed overhead projectors or electronic blackboards in the classroom are common place and facilitate the knowledgebuilding process. Moreover, computers in the classroom are a powerful tool linking theory and problem-solving practice in engineering studies (Beyerlein et al., 1993). On the other hand, the assessment process has been evolving slowly in the last decades. Pen-and-paper examination techniques have been translated to the computer-enabled classroom as software applications that present an exam in the screen and record the student answers. This process can be seen as an external assessment targeting to evaluate the skills of the student in order to give a pass/fail on a given subject. The external evaluation can be useful for the student in order to know the skill level, but usually fails short when the student wants to now “what’s wrong”, i.e. to know not only what question was missed but also what knowledge areas the student is finding difficulties. Weak areas identification cannot be done from a single question or set of questions. It requires the assessment process, examination or similar, to be considered as a whole. Student attention time or time spent thinking on a specific question –relative to the other question, as some students think faster than othersclearly indicates the areas where difficulties hide, by example. The pattern followed when answering the exam questions, by example, is another useful indicator. The student will try to answer first the questions he feels more comfortable with. Dubitation on the answer –change the answer several times– is another useful parameter. All these parameters and many others can be compiled and processed by the unprecedented analytic processing capabilities of modern data mining techniques. Collaborative assessment appears as a the natural evolution from the individual learning to the collaborative learning, which was proposed as a suitable technique to speed-up development of analytical reasoning as different approaches are continuously suggested
Improved Inception-Residual Convolutional Neural Network for Object\n Recognition (2017)

Machine learning and computer vision have driven many of the greatest\nadvances in the modeling of Deep Convolutional Neural Networks (DCNNs).\nNowadays, most of the research has been focused on improving recognition\naccuracy with better DCNN models and learning approaches. The recurrent\nconvolutional approach is not applied very much, other than in a few DCNN\narchitectures. On the other hand, Inception-v4 and Residual networks have\npromptly become popular among computer the vision community. In this paper, we\nintroduce a new DCNN model called the Inception Recurrent Residual\nConvolutional Neural Network (IRRCNN), which utilizes the power of the\nRecurrent Convolutional Neural Network (RCNN), the Inception network, and the\nResidual network. This approach improves the recognition accuracy of the\nInception-residual network with same number of network parameters. In addition,\nthis proposed architecture generalizes the Inception network, the RCNN, and the\nResidual network with significantly improved training accuracy. We have\nempirically evaluated the performance of the IRRCNN model on different\nbenchmarks including CIFAR-10, CIFAR-100, TinyImageNet-200, and CU3D-100. The\nexperimental results show higher recognition accuracy against most of the\npopular DCNN models including the RCNN. We have also investigated the\nperformance of the IRRCNN approach against the Equivalent Inception Network\n(EIN) and the Equivalent Inception Residual Network (EIRN) counterpart on the\nCIFAR-100 dataset. We report around 4.53%, 4.49% and 3.56% improvement in\nclassification accuracy compared with the RCNN, EIN, and EIRN on the CIFAR-100\ndataset respectively. Furthermore, the experiment has been conducted on the\nTinyImageNet-200 and CU3D-100 datasets where the IRRCNN provides better testing\naccuracy compared to the Inception Recurrent CNN (IRCNN), the EIN, and the\nEIRN.\n
A “crab-like” A6 relativistic magnetron with diffraction output driven by a transparent cathode (2019)

We present the design of an A6 relativistic magnetron with diffraction output (MDO) which looks like a crab and we named it the “crab-like” A6 MDO. This article shows that the crab-like A6 MDO driven by a transparent cathode can radiate the TE11 mode with an output power of about 1 GW when an optimized applied voltage of U=440 kV and magnetic field of B=0.43 T are used. Its electronic efficiency, as obtained using UNIPIC particle-in-cell (PIC) simulations, can be as high as 44% in S-band. The UNIPIC PIC code used in simulations also demonstrates that the crab-like A6 MDO can radiate both two electron spokes in the TE21 mode with an operating frequency of 2.1 GHz and four electron spokes in the TE21 mode with an operating frequency of 2.5 GHz when different magnetic field amplitudes are used for an applied voltage of U=400 kV. This result suggests that this configuration is favorable for mode switching. This work seeks to design a compact high power microwave source for a narrowband directed microwave wave beam that is suitable for mode switching investigations.
Low temperature pressure-oxidation of silicon for integrated circuit technology (1977)

It was reasoned that dry oxygen pressures above 1 atm would appreciably accelerate the oxidation of silicon, thereby leading to lower oxidation temperatures, reduced defect concentrations, and improved electrical properties. Special apparatus has been developed, and careful experimentation has demonstrated that oxidation temperatures can be lowered as much as 400C by using only 140 atm dry oxygen pressure, i.e., a pressure lower than that contained in commercial bottled gas cylinders. Measurements have shown that the resultant oxidized material has a stable flat-band voltage, consistently low fixed surface-state-charge density, high dielectric strength, and a generally lower defect concentration relative to conventionally processed silicon. The use of pressure-oxidation (P-OX) to obtain oxide-isolated integrated circuits on sapphire to meet military requirements for low power and radiation hardening was demonstrated.
Experimental Demonstration of Multiple Robot Cooperative Target Intercept (2002)

This paper presents experimental results for the simultaneous intercept of preassigned targets by a team of mobile robots. The robots are programmed to mimic the dynamic behavior of unmanned air vehicles in constant-altitude flight. In proceeding to their targets, robots must avoid both known static threats and pop-up threats. An overview of the cooperative control strategy followed is given, as well as a description of the robot hardware and software used. Experimental results demonstrating simultaneous intercept of targets by the robot team are presented.
Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength (2016)

Glutamatergic synapses show large variations in strength and short-term plasticity (STP). We show here that synapses displaying an increased strength either after posttetanic potentiation (PTP) or through activation of the phospholipase-C-diacylglycerol pathway share characteristic properties with intrinsically strong synapses, such as (i) pronounced short-term depression (STD) during high-frequency stimulation; (ii) a conversion of that STD into a sequence of facilitation followed by STD after a few conditioning stimuli at low frequency; (iii) an equalizing effect of such conditioning stimulation, which reduces differences among synapses and abolishes potentiation; and (iv) a requirement of long periods of rest for reconstitution of the original STP pattern. These phenomena are quantitatively described by assuming that a small fraction of "superprimed" synaptic vesicles are in a state of elevated release probability (p ∼ 0.5). This fraction is variable in size among synapses (typically about 30%), but increases after application of phorbol ester or during PTP. The majority of vesicles, released during repetitive stimulation, have low release probability (p ∼ 0.1), are relatively uniform in number across synapses, and are rapidly recruited. In contrast, superprimed vesicles need several seconds to be regenerated. They mediate enhanced synaptic strength at the onset of burst-like activity, the impact of which is subject to modulation by slow modulatory transmitter systems.
Transition-Metal Tris-Bipyridines Containing Three Dithienylcyclopentenes: Synthesis, Photochromic, and Electrochromic Properties (2009)

Designed prototype molecules for making a three-terminal single-molecule device, star-shaped Fe(II), Co(II), and Ru(II) tris-bipyridine complexes containing three dithienylcyclopentenes, have been synthesized and characterized. All complexes displayed reversible photochromic behavior when irradiated with UV or visible light. The open form of these complexes could be cyclized electrochemically as revealed by cyclic voltammetric studies and bulk electrolysis experiments.
ChemInform Abstract: THE FORMATION OF CYCLOPENTADECANE‐1,5‐DIONE DERIVATIVES BY AN OXIRANYLMETHYL FRAGMENTATION. A SYNTHESIS OF MUSCONE (1977)

Abstract Reduktion der bekannten Enone (I) [→(II)], Epoxidation und Tosylierung führen zu den Verbindungen (III), deren Fragmentierung die Diketone (IV) liefert.
Coronary artery stretch versus deep injury in the development of in-stent neointima (2002)

Stretch of the coronary artery in a stent is common, and a major contributor to neointima formation, even in the absence of deep injury. Deep injury is, however, a more potent stimulus to neointima formation than stretch. Greater degrees of stretch are associated with thicker neointima. Where neither deep injury nor stretch are seen, the stent has no effect upon the development of neointima.
Components of the revised International Prognostic Scoring System and outcome after hematopoietic cell transplantation for myelodysplastic syndrome (2013)

To the editor:

Despite the proven curative potential of allogeneic hematopoietic cell transplantation (HCT) for patients with myelodysplastic syndrome, posttransplant relapse is common in patients with high-risk cytogenetics. One strategy to improve post-HCT outcome may be to accurately identify
Biologic Therapies: Anti-Tumor Necrosis Factor-α, Anti-Interleukins, Rituximab and Others (2015)

Biologic agents are a group of therapeutic agents targeting mediators of inflammation, including soluble factors (e.g. cytokines and chemokines), cytokine/chemokine receptors and immune cell surface markers. The purpose of this chapter is to introduce the use of biologic therapies for the treatment of ocular inflammatory diseases. Anti-tumor necrosis factor agents, particularly infliximab and adalimumab, are well studied. We will review these, as well as newer options in the development of more targeted therapy, including anti-interleukins, anti-cell surface molecule biologics and interferon-2α. Biologic treatment of ocular inflammatory disease has advanced rapidly over the past 10 years and continues to be an exciting field of study.
ChemInform Abstract: Synthesis of Aromatic Compounds by Catalytic C—C Bond Activation of Biphenylene or Angular [3]Phenylene. (2012)

Abstract Biphenylene (I) or angular [3]phenylene (IV) undergo an iridium‐catalyzed reaction with various internal alkynes to give substituted phenanthrenes and picenes, correspondingly.
Classification of Application Development for FPGA-Based Systems (2008)

Field-programmable gate arrays (FPGAs) have been used to accelerate DoD-related applications with promising performance. However, current development tools require significant hardware knowledge and are not amenable to the increasing complexity of FPGA-based systems. The application requirements are expected to change dramatically for future use cases, and require a well defined development methodology. This paper presents the results obtained after conducting an extensive survey and study about current FPGA tools. A classification for DoD use cases and FPGA tools is provided. This classification provides the current status of the available tools and identifies current tool limitations for DoD use cases.
Silicon Solar Cell Passivation using Heterostructures (2007)

Standard surface passivation schemes for crystalline silicon solar cells use SiO2 or SiNx. The c-Si surface passivation mechanisms related with these schemes have been elucidated within the framework of interface recombination modeled by an extended SRH formalism: interface recombination centers characteristic of the SiO2 passivation have larger electron (e-) than hole (h+) capture cross sections and SiO2 yields thus poorer passivation of lower resistivity p-type c-Si, while SiNx layers lead to the occurrence of a large fixed charge density leading, for instance, to parasitic leakage currents that adversely affect the performance of SiNx rear passivated p-type c-Si solar cells. An alternative to these two major schemes is hydrogenated amorphous silicon (a-Si:H). In this paper, we determine first differences between the natures of the electronic recombination centers. To understand the passivation properties of a-Si:H, we then introduce an interface recombination model based on the amphoteric nature of silicon dangling bonds. We show experimentally and theoretically that a-Si:H is a high performance and broad range surface passivation material as its e- and h+ capture cross sections on neutral defects are similar, while additional field effect passivation can be tuned by further growth of doped a-Si:H layers. The quality of the passivation is illustrated with a lifetime of 7ms reached on lightly p-type doped c-Si passivated with intrinsic a-Si:H, which is to the best of our knowledge the highest ever measured value for a-Si:H passivated wafers. By using our modeling of the a-Si:H/c-Si interface recombination as a guidance for interface and solar cell improvement, we are able to fabricate full a-Si:H/c-Si heterojunction devices reaching a maximal open-circuit voltage of 713mV and a maximal efficiency of 19.1 % on flat c-Si wafers, using very high frequency plasma enhanced chemical vapor deposition (VHF-PECVD).
Electrochemical Study of Aromatic Ketones in 1-Ethyl-3-methylimidazolium tetrafluoroborate (2007)

The electrochemical reduction of 9-fluorenone and benzophenone has been studied in the 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIBF4) ionic liquid. A comparison of potential separation for successive 9-fluorenone reduction processes in EMIBF4 at 100 mV/s with those in acetonitrile provides evidence for complexation of the 9-fluorenone dianion by the EMI+ cation. Complexation of the 9-fluorenone carbonyl oxygen by added BF3 etherate has also been studied, producing a positive potential shift for the reduction process. The reduction of benzophenone in EMIBF4 shows two successive electron transfers only at higher scan rates (1 V/s), suggesting that proton transfer and / or complexation of benzophenone reduction products by the EMI+ cation may be involved. The peak potential separation for the benzophenone reduction processes at 1 V/s is similar to that for 9- fluorenone at 100 mV/s, indicating that the EMI+ cation also complexes the benzophenone dianion.