gebhart/patrepeval huggingface dataset:
Change of the lateral chain conformation in the solid and the nematic phase in laterally substituted nematogens (1995)

Abstract A new homologous series of 4-(4′-ethoxybenzoyloxy)-2-alkoxy-4′-(4-butoxysalicylaldimine)-azobenzenes has been synthesized. These compounds contain four rings in the main core and a lateral alkoxy branch on one of the inner rings and present enantiotropic nematic properties. The X-ray crystal structure (MoKα radiation, λ = 0.7071 Å, graphite monochromator) of 4-(4′-ethoxybenzoyloxy)-2-butoxy-4′-(4-butoxysalicylaldimine)azobenzene was investigated (T = 293K, R = 0.059 for the 2855 observed reflections). This compound (C36H39N3O6) crystallizes in the monoclinic system with C2/c space group; (Z = 8); a = 28.052(7) A, b = 7.545(4) Å, c = 33.823(7) Å and β = 112.70(1)°. There is a strong chelated hydrogen bond between the OH group and the neighbouring nitrogen atom engaged in the imine bridge. In the solid state, the molecule is roughly linear with a 31 Å length. The lateral butoxy chain is quasi-perpendicular to the long axis of the main core. The crystal cohesion is due to numerous Van der Waals interactions. At the solid to nematic transition, a change in the conformation of the lateral chain occurs from an all trans-conformation to one involving a cis-conformation in the first part of the lateral chain. This change can be monitored by the evolution of the 13C chemical shift of the OCH2 belonging to the lateral alkoxy chain.
The selective generation of trans-substituted lithium and sodium ethenesulfenate anions (1993)

A. L. Schwan, M. F. Pippert, H. H. Pham and M. R. Roche, J. Chem. Soc., Chem. Commun., 1993, 1312 DOI: 10.1039/C39930001312
Computational Modeling of Progressive Damage in Composite Laminates (2003)

Peer Reviewed
Palladium(<scp>II</scp>) complexes derived from the potentially chelating ligands 2,2,NN-tetramethylpent-4-enylamine and 2,2-dimethylpent-4-enyl methyl sulphide. Crystal structures of dichloro[2,2-dimethylpent-(E)-3-enyl methyl sulphide]palladium(<scp>II</scp>) and chloro[1–3-η-syn-1-(1,1′-dimethyl-2′-methylthioethyl)allyl]palladium(<scp>II</scp>) (1980)

Reaction of PdX2·2PhCN(X = Cl or Br) with 2,2,NN-tetramethylpent-4-enylamine (1a) gives complexes (2) of stoicheiometry PdX2·(1a) in which Pd–X has added to the olefinic bond to generate a seven-membered chelate ring. In contrast, 2,2-dimethylpent-4-enyl methyl sulphide (1b) initally gives labile olefinic complexes, which readily rearrange to the derivatives (5a) and (5b) of 2,2-dimethylpent-(E)-3-enyl methyl sulphide (13). Variable-temperature 1H n.m.r. studies show that at low temperatures (5a) and (5b) exist in solution as pairs of epimers at sulphur, while heating leads first to equilibration of the epimers and then to labilisation of the metal–olefin bond. The π-allyl species (6a) and (6b) have been prepared from (5a) and (5b). X-Ray structures of (5a) and (6a) are reported. Crystals of (5a) are monoclinic, space group P21/n with Z= 4 in a unit cell of dimensions a= 8.365(2), b= 15.068(2), c= 9.595(1)Å, and β= 94.00(1)°. Crystals of 6(a) are monoclinic, space group P21/c, with Z= 4 in a unit cell of dimensions a= 6.583, b= 12.462, c= 12.859(6)Å, and β= 96.20(5)°. Both structures have been solved by the heavy-atom method and refined by full-matrix least-squares calculations to R= 0.023 for 2 414 reflections for (5a) and to R= 0.046 for 2 515 reflections for (6a). The five-membered chelate rings in (5a) and(6a) have C(2)-envelope conformations. In (5a) principal dimensions are Pd–Cl 2.313 and 2.320(1), Pd–S 2.269(1), and Pd–C 2.195 and 2.231(3)Å, and the interplanar angle between the PdCl2S plane ad the Pd–ethylenic carbon plane is 96.0°. In (6a) dimensions are Pd–Cl 2.381(1), Pd–S 2.364(1), Pd–C 2.089, 2.120, and 2.173(5)Å; the plane of the allyl moiety forms a dihedral angle of 116.4° with the PdSCIC(5) plane.
G to A polymorphism in exon 31 of the COL3A1 gene (1990)

Journal Article G to A polymorphism in exon 31 of the COL3A1 gene Get access Khaja Zafarullah, Khaja Zafarullah Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson UniversityPhiladelphia, PA 19107-6799, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Caren Kleinert, Caren Kleinert Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson UniversityPhiladelphia, PA 19107-6799, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerard Tromp, Gerard Tromp * Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson UniversityPhiladelphia, PA 19107-6799, USA *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Helena Kuivaniemi, Helena Kuivaniemi Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson UniversityPhiladelphia, PA 19107-6799, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Sirpa Kontusaari, Sirpa Kontusaari Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson UniversityPhiladelphia, PA 19107-6799, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuli Wu, Yuli Wu Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson UniversityPhiladelphia, PA 19107-6799, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Arupa Ganguly, Arupa Ganguly Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson UniversityPhiladelphia, PA 19107-6799, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Darwin J. Prockop Darwin J. Prockop Department of Biochemistry and Molecular Biology, Jefferson Medical College, Thomas Jefferson UniversityPhiladelphia, PA 19107-6799, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 20, 25 October 1990, Page 6180, https://doi.org/10.1093/nar/18.20.6180 Published: 25 October 1990
ADP-dependent 6-Phosphofructokinase from Pyrococcus horikoshii OT3 (2009)

Some hyperthermophilic archaea use a modified glycolytic pathway that employs an ADP-dependent glucokinase (ADP-GK) and an ADP-dependent phosphofructokinase (ADP-PFK) or, in the case of Methanococcus jannaschii, a bifunctional ADP-dependent glucophosphofructokinase (ADP-GK/PFK). The crystal structures of three ADP-GKs have been determined. However, there is no structural information available for ADP-PFKs or the ADP-GK/PFK. Here, we present the first crystal structure of an ADP-PFK from Pyrococcus horikoshii OT3 (PhPFK) in both apo- and AMP-bound forms determined to 2.0-A and 1.9-A resolution, respectively, along with biochemical characterization of the enzyme. The overall structure of PhPFK maintains a similar large and small alpha/beta domain structure seen in the ADP-GK structures. A large conformational change accompanies binding of phosphoryl donor, acceptor, or both, in all members of the ribokinase superfamily characterized thus far, which is believed to be critical to enzyme function. Surprisingly, no such conformational change was observed in the AMP-bound PhPFK structure compared with the apo structure. Through comprehensive site-directed mutagenesis of the substrate binding pocket we identified residues that were critical for both substrate recognition and the phosphotransfer reaction. The catalytic residues and many of the substrate binding residues are conserved between PhPFK and ADP-GKs; however, four key residues differ in the sugar-binding pocket, which we have shown determine the sugar-binding specificity. Using these results we were able to engineer a mutant PhPFK that mimics the ADP-GK/PFK and is able to phosphorylate both fructose 6-phosphate and glucose.
Aerial imaging performance of ALTA4700 printed mask for 130nm design rule (2007)

Photomask plays a key role in optical lithography. Laser pattern generators are widely used for photomask manufacturing due to their high throughput. However, corner rounding and line-end shortening degrade pattern fidelity resulting in distorted pattern image s on wafer. ALTA 4700 incorporates a new 0.9 NA, 42X reduction lens that significantly improves resolution and pattern accuracy performance. In this study, three critical line/space 130nm technology device patterns are printed by ALTA4700 laser pattern generator. Input data for these layers was based on existing OPC model generated for e-beam pattern generator. ALTA4700 printed masks have the same aerial image performance compare with e-beam pattern generator.
VHDL-AMS Modelling of Continuous-Time Complex Bandpass Delta Sigma Modulator (2007)

International audience
Giga-Cycle Property of a New Age-Hardened Aluminium Alloy Containing Excess Solute Magnesium (2013)

The giga-cycle property of a newly developed Al alloy, which contains 0.5wt.% excess Mg solute compared to a standard age-hardened 6061 alloy (6061-T6), was investigated by using smooth specimens subjected to ultrasonic fatigue. The fatigue strength of the new alloy was higher than that of a normal 6061 alloy particularly at relatively low stress amplitude level. Several analyses (surface crack observation, fractography, FIB cross-sectioning, etc.) were also conducted to reveal the micro-mechanism of the observed strength properties. The following results were obtained: i) No fatigue limit was confirmed for both 6061 and new alloy. ii) Total life ( N f ) of 6061 and new alloys was determined by a single fatigue crack initiated from a surface PSB crack. iii) Crack initiation resistance defined by N 25 (number of cycles to reach ρ = 25 mm -2 , where ρ is the PSB crack number density) for new alloy was higher than that of 6061. iv) The higher fatigue strength of new alloy was explained by the effect of excess Mg solute which increased the resistance against the formation of PSB cracks.
Human immunodeficiency virus, hepatitis C, and inflammatory biomarkers in individuals with alcohol problems: a cross-sectional study (2013)

Detectable HIV and HCV replication versus undetectable replication was associated with inflammatory burden and certain inflammatory biomarkers independently of alcohol consumption, liver fibrosis and other comorbidities.
Redundancy of stereoscopic images: Experimental evaluation (2005)

With the recent advancement in visualization devices over the last years, we are seeing a growing market for stereoscopic content. In order to convey 3D content by means of stereoscopic displays, one needs to transmit and display at least 2 points of view of the video content. This has profound implications on the resources required to transmit the content, as well as demands on the complexity of the visualization system. It is known that stereoscopic images are redundant which may prove useful for compression and may have positive effect on the construction of the visualization device. In this paper we describe an experimental evaluation of data redundancy in color stereoscopic images. In the experiments with computer generated and real life test stereo images, several observers visually tested the stereopsis threshold and accuracy of parallax measurement in anaglyphs and stereograms as functions of the blur degree of one of two stereo images. In addition, we tested the color saturation threshold in one of two stereo images for which full color 3D perception with no visible color degradations was maintained. The experiments support a theoretical estimate that one has to add, to data required to reproduce one of two stereoscopic images, only several percents of that amount of data in order to achieve stereoscopic perception.
A primary pressure standard at 100 kPa (1999)

Primary pressure standards in the atmospheric pressure range are often established using mercury manometers. To a lesser extent, controlled-clearance dead-weight testers, in which one component (normally the piston) has been dimensionally measured, have also been used. The recent advances in technology on two fronts: (i) the fabrication of large-diameter pistons and cylinders with good geometries; and (ii) the dimensional metrology capability of these components, have allowed some dead-weight testers at the National Institute of Standards and Technology (NIST) to achieve total relative uncertainties (2 σ) in generated pressure near 10 × 10-6 (10 ppm). This paper describes recent developments at the NIST in which accurate dimensional measurements have been translated into effective areas. It is anticipated that total relative uncertainties in generated pressure may decrease to 5 ppm (2 σ) when recent dimensional measurements are incorporated in the newest gauges.
Donor CD8+ T Cells Mediate GVL without GVHD in Recipients Conditioned with Anti-CD3 mAb. (2006)

Abstract Donor CD8+ T cells play a critical role in mediating graft versus leukemia (GVL), but also induce graft versus host disease (GVHD) in recipients conditioned with total body irradiation (TBI). Here, we report that injections of donor C57BL/6 (H-2b) or FVB/N (H-2q) CD8+ T with bone marrow cells induced chimerism and eliminated BCL1 leukemia/lymphoma cells without GVHD in anti-CD3-conditioned BALB/c (H-2d) recipients. In contrast, the same dose of donor CD8+ T and marrow cells induced lethal GVHD in TBI-conditioned recipients. In addition, the anti-CD3-conditioned long-term complete chimeras without prior exposure to host-type BCL1 cells also eliminated the tumors when being challenged with BCL1 cells 120 days after HCT. This is in contrast to the report that long-term complete chimeras induced with delayed donor lymphocyte infusion lost GVL activity. Using in vivo and ex vivo bioluminescent imaging, we observed that donor CD8+ T cells expanded rapidly and infiltrated GVHD target tissues in TBI-conditioned recipients, but donor CD8+ T cell expansion in anti-CD3-conditioned recipients was confined to lympho-hematological tissues. This confinement was associated with lack of up-regulated expression of α4β7 integrin and chemokine receptors (i.e. CXCR3) on donor CD8+ T cells. In addition, host-reactive donor CD8+ T cells in anti-CD3-conditioned recipients were only partially deleted, and the residual cells were rendered heterogeneous: some unresponsive/anergic, some Tc2, some Foxp3+ suppressive cells, and some effector cells. The whole population of residual donor CD8+ T cells from anti-CD3-conditioned recipients mediated GVL without GVHD in TBI-conditioned secondary recipients. These results indicate that anti-CD3-conditioning separates GVL from GVHD via confining donor CD8+ T cell expansion to host lympho-hematological tissues as well as tolerization of the residual donor CD8+ T cells, in which the residual host-reactive effector cells mediate persistent GVL, and the regulatory CD8+ T cells prevent them from damaging host tissues.
405 MINOCYCLINE THROUGH SUPPRESSION OF CYTOCHROME C AND DIABLO RELEASE ATTENUATES MALE GERM CELL APOPTOSIS AFTER HORMONE WITHDRAWAL (2005)

Manuscript Submission Guidelines: Journal if Investigative Medicine (JIM) This Journal recommends that authors follow the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals formulated by the International Committee of Medical Journal Editors (ICMJE). Please read the guidelines below and then visit the Journal’s submission
The Structure of Isojervine<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Isojervine1William G. Dauben, William W. Epstein, Masato Tanabe, and Boris WeinsteinCite this: J. Org. Chem. 1963, 28, 2, 293–297Publication Date (Print):February 1, 1963Publication History Published online1 May 2002Published inissue 1 February 1963https://pubs.acs.org/doi/10.1021/jo01037a003https://doi.org/10.1021/jo01037a003research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamics of H3K4me3 Chromatin Marks Prevails over H3K27me3 for Gene Regulation during Flower Morphogenesis in Arabidopsis thaliana (2017)

Plant life-long organogenesis involves sequential, time and tissue specific expression of developmental genes. This requires activities of Polycomb Group (PcG) and trithorax Group complexes (trxG), respectively responsible for repressive Histone 3 trimethylation at lysine 27 (H3K27me3) and activation-related Histone 3 trimethylation at lysine 4 (H3K4me3). However, the genome-wide dynamics in histone modifications that occur during developmental processes have remained elusive. Here, we report the distributions of H3K27me3 and H3K4me3 along with expression changes, in a developmental series including Arabidopsis thaliana leaf and three stages of flower development. We found that chromatin mark levels are highly dynamic over the time series on nearly half of all Arabidopsis genes. Moreover, during early flower morphogenesis, changes in H3K4me3 prevail over changes in H3K27me3 and quantitatively correlate with expression changes, while H3K27me3 changes occur later. Notably, we found that H3K4me3 increase during the early activation of PcG target genes while H3K27me3 level remain relatively constant at the locus. Our results reveal that H3K4me3 predicts changes in gene expression better than H3K27me3, unveil unexpected chromatin mechanisms at gene activation and underline the relevance of tissue-specific temporal epigenomics.
Cross-supervised synthesis of web-crawlers (2016)

A web-crawler is a program that automatically and systematically tracks the links of a website and extracts information from its pages. Due to the different formats of websites, the crawling scheme for different sites can differ dramatically. Manually customizing a crawler for each specific site is time consuming and error-prone. Furthermore, because sites periodically change their format and presentation, crawling schemes have to be manually updated and adjusted. In this paper, we present a technique for automatic synthesis of web-crawlers from examples. The main idea is to use hand-crafted (possibly partial) crawlers for some websites as the basis for crawling other sites that contain the same kind of information. Technically, we use the data on one site to identify data on another site. We then use the identified data to learn the website structure and synthesize an appropriate extraction scheme. We iterate this process, as synthesized extraction schemes result in additional data to be used for re-learning the website structure. We implemented our approach and automatically synthesized 30 crawlers for websites from nine different categories: books, TVs, conferences, universities, cameras, phones, movies, songs, and hotels.
Experimental immunology<br>The influence of aqueous and hydro-alcoholic extracts of roots and rhizomes of Rhodiola kirilowii on the course of pregnancy in mice (2014)

Plants belonging to the Rhodiola genus, originating from Asia, are traditionally used as tonic, adaptogen, antidepressant and anti-inflammatory drugs. These plants have also potent immunomodulatory properties and in some situations possibly could be used instead of standard antibiotic therapy (e.g. during pregnancy or lactation). The aim of our present study was to establish whether aqueous (RKW) or hydro-alcoholic (RKW-A) extracts from roots and rhizomes of Rhodiola kirilowii given to pregnant mice influence the course of pregnancy and the number of progeny. Performed HPLC analysis showed that the RKW-A extract had a generally higher concentration of all identified polyphenols. The highest differences were observed for (+)-catechin, p-coumaric acid and naringenin. Everyday addition of the RKW or RKW-A extract did not change the length of pregnancy. At the same time, both RKW and RKW-A extracts significantly increased the number of mated females without offspring but only in the RKW-A group we noticed a few neonatal deaths in the first 5 days after delivery. The results reported in the present study do not encourage to the use of R. kirilowii hydro-alcoholic extracts supplementation during pregnancy and lactation, however the possibility of limited dietary intake of R. kirilowii water extract should be thoroughly examined.
Lysine Adsorption on Cation Exchange Resin. IV. Temperature Effects on Equilibrium and Kinetics in Batch and Column Systems (2008)

Abstract Ion exchange equilibria and kinetics are determined for lysine adsorption on the strong acid cation exchanger DIAION SK‐1B at temperatures of 25, 40, and 60°C. The ion exchange equilibrium is found to be independent of temperature. Conversely, the kinetics of ion exchange increases dramatically as the temperature is increased. Average ion exchange selectivity coefficients of 6.0 g/cm3 and 0.52 are obtained for the ion exchange of divalent and monovalent cationic lysine with hydrogen ion, respectively. Resin phase diffusivities are determined by fitting batch binary ion‐exchange data with a mass transfer model based on the Nernst‐Planck equations. As the temperature is increased from 25 to 60°C, the resin phase diffusivity increases from 0.04×10−6 to 0.14×10−6 cm2/s for divalent lysine and from 0.16×10−6 to 0.55×10−6 cm2/s for monovalent lysine. The combination of temperature‐independent ion exchange equilibria and faster mass transfer at higher temperatures results in higher dynamic binding capacity and more efficient desorption of lysine when ion exchange is operated at an elevated temperature. This behavior is confirmed by means of column adsorption/desorption experiments whose results are found to be in agreement with a model incorporating the equilibrium and mass transfer data obtained in this work.
Dereverberation sweet spot dilation with combined channel equalization and beamforming (2015)

Beamforming and channel equalizers can be formulated as optimal multichannel filter-and-sum operations with different objective criteria. It has been shown in previous studies that the combination of both concepts under a common framework can yield results that combine both the spatial robustness of beamforming and the dereverberation performance of channel equalization. This paper introduces an additional method for leveraging both approaches that exploits channel estimates in a wanted spatial location and derives robustness from knowledge of the array geometry alone. Experiments with an objective assessment of speech quality as a function of source perturbation reveal that the proposed technique can be viewed as a sweet spot dilator when compared with the MINT channel equalizer.