gebhart/patrepeval huggingface dataset:
Expression of the Mu Opioid Receptor in the Human Immunodeficiency Virus Type 1 Transgenic Rat Model (2007)

Opioids, via the mu opioid receptor (MOR), can exacerbate bacterial infections and the immunopathogenesis of human immunodeficiency virus type 1 (HIV-1) infection. Recently, an HIV-1 transgenic (HIV-1Tg) rat model containing circulating HIV-1 gp120 was created. Using real-time reverse transcription-PCR, we found that MOR mRNA levels were significantly higher in the peritoneal macrophages of the HIV-1Tg rat than those in control animals. Lipopolysaccharide, a bacterial endotoxin, induced secretion of the inflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin-beta (IL-beta), and IL-10 in the HIV-1Tg rat and further increased MOR expression. Ex vivo studies showed that MOR expression was up-regulated in the peritoneal macrophages of F344 control rats by exposure to serum from HIV-1Tg rats and that MOR up-regulation was abolished by addition of gp120 antibody to the serum. In human TPA-differentiated HL-60 cells, which are macrophage-like cells, LPS-induced MOR mRNA up-regulation was greater in gp120-pretreated cells than in vehicle-pretreated cells. Our data suggest that in individuals infected with HIV-1, the MOR is up-regulated, possibly by circulating HIV-1 proteins such as gp120, and HIV-1 proteins may play a significant role in modulating the response to bacterial infection in opioid-using HIV-infected individuals. Furthermore, our results demonstrate that the new HIV-1Tg rat model can be a valuable tool with which to study MOR gene expression and its effects in the continuous presence of HIV viral proteins.
Hierarchical Photon Mapping (2008)

Photon mapping is an efficient method for producing high-quality, photorealistic images with full global illumination. In this paper we present a more accurate and efficient approach to final gathering using the photon map based upon hierarchical evaluation of the photons over each surface. We use the footprint of each gather ray to calculate the irradiance estimate area rather than deriving it from the local photon density. We then describe an efficient method for computing the irradiance from the photon map given an arbitrary estimate area. Finally, we demonstrate how the technique may be used to reduce variance and increase efficiency when sampling diffuse and glossy-specular BRDFs.
Cost Control Method and Software in Bidding Process Based on Gray System Forecast (2014)

With the fast development of social economy, the competition between enterprises in construction projects becomes more and more serious. The cost control method is proposed to the bidding process of enterprises based on the gray system forecast. At the same time, the cost control software is also constructed to the bidding process of enterprises. Experimental results suggest that the proposed approach is feasible and correct.
Effect of external cation concentration and metabolic inhibitors on membrane potential of human glial cells. (1993)

1. The effect on membrane potential (Em) of low external [K+]o, [Na+]o and [Ca2+]o and of metabolic inhibitors was studied in cultured human glial cells (U-787CG) and human glioma cells (Tp-483MG and U-251MG). Whole cells were voltage or current clamped with the tight-seal recording technique. 2. Em was -76 and -80 mV in glial and glioma cells (mean values in U-787CG and U-251MG, respectively) in a reference external solution with 3.0 mM K+. K(+)-free external solution caused a rapid and reversible depolarization of these cells by about 26 and 42 mV (respectively). 3. Block of K+ channels with 1 mM Ba2+ in external solution rapidly depolarized the cells (U-251MG) by about 35 mV. 4. Na(+)-free solutions caused a delayed depolarization by 40-50 mV, which was slowly reversible (in 2 min). 5. Ouabain (1 mM) depolarized the cells by about 4 mV. It did not prevent the effect of K(+)-free solution. 6. Ca(2+)-free external solution rapidly depolarized the cells to Em about -17 mV. The combination of either Na(+)-K(+)-free or Na(+)-Ca(2+)-free solution transiently repolarized the cell, which indicated that the K+ selectivity of the membrane was decreased in both K(+)- and Ca(2+)-free solutions. 7. Metabolic inhibitors (carbonyl cyanide p-trifluoromethoxy-phenylhydrazone (FCCP) and 2,4-dinitrophenol (DNP)) rapidly and reversibly depolarized the cells. This effect was not prevented by intracellular perfusion of a strong Ca(2+)-buffering solution. 8. Voltage clamp revealed only minor changes (< 20%) in the leak conductance (g) of cells that were depolarized by the above-mentioned solutions. 9. Positive polarizing current elicited (in some cells) a regenerative depolarization. The threshold for depolarization was less in low external [K+]o. 10. It is concluded (a) that the resting potential of these glial cells depends on ion channels that are K+ selective only in the presence of external Ca2+ and K+ and (b) that this K+ selectivity may require that Em is near the reversal potential for potassium (EK), and (c) that the action of metabolic inhibitors (DNP and FCCP) is different from that in neurones.
Synthesis of 5‐Substituted 1<i>H</i>‐Tetrazoles from Nitriles and Hydrazoic Acid by Using a Safe and Scalable High‐Temperature Microreactor Approach (2010)

Harnessing hydrazoic acid in a microreactor! Tetrazoles have been synthesized in a very efficient manner by using a high-temperature/high-pressure process intensification regime. Despite the toxic and explosive nature of hydrazoic acid, the synthesis was conducted safely in continuous flow format with residence times as short as 2.5 minutes at 260 °C (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Preventable hospitalizations and access to health care (1995)

<h3>Objective.</h3> —To examine whether the higher hospital admission rates for chronic medical conditions such as asthma, hypertension, congestive heart failure, chronic obstructive pulmonary disease, and diabetes in low-income communities resulted from community differences in access to care, prevalence of the diseases, propensity to seek care, or physician admitting style. <h3>Design.</h3> —Analysis of California hospital discharge data. We calculated the hospitalization rates for these five chronic conditions for the 250 ZIP code clusters that define urban California. We performed a random-digit telephone survey among adults residing in a random sample of 41 of these urban ZIP code clusters stratified by admission rates and a mailed survey of generalist and emergency physicians who practiced in the same 41 areas. <h3>Setting.</h3> —Community based. <h3>Participants.</h3> —A total of 6674 English- and Spanish-speaking adults aged 18 through 64 years residing in the 41 areas were asked about their access to care, their chronic medical conditions, and their propensity to seek health care. Physician admitting style was measured with written clinical vignettes among 723 generalist and emergency physicians practicing in the same communities. <h3>Main Outcome Measures.</h3> —We compared respondents' reports of access to medical care in an area with the area's cumulative admission rate for these five chronic conditions. We then tested whether access to medical care remained independently associated with preventable hospitalization rates after controlling for the prevalence of the conditions, health care seeking, and physician practice style. <h3>Results.</h3> —Access to care was inversely associated with the hospitalization rates for the five chronic medical conditions (<i>R</i><sup>2</sup>=0.50;<i>P</i><.001). In a multivariate analysis that included a measure of access, the prevalence of conditions, health care seeking, and physician practice style to predict cumulative hospitalization rates for chronic medical conditions, both self-rated access to care (<i>P</i><.002) and the prevalence of the conditions (<i>P</i><.03) remained independent predictors. <h3>Conclusion.</h3> —Communities where people perceive poor access to medical care have higher rates of hospitalization for chronic diseases. Improving access to care is more likely than changing patients' propensity to seek health care or eliminating variation in physician practice style to reduce hospitalization rates for chronic conditions. (<i>JAMA</i>. 1995;274:305-311)
Traumatic Brain Injury & Acidosis (2006)

74 p. A THESIS Presented to the Department of Biology and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of Science. November 2006. A print copy of this title is available through the UO Libraries under the call number: SCA Archiv Force 2006
Rate-limiting steps in the interconversion of purine ribonucleotides in Ehrlich ascites tumor cells in vitro. (1971)

The conversion of inosinate to guanylate in Ehrlich ascites tumor cells incubated in vitro in Krebs-Ringer phosphate medium is limited first by the concentration of glutamine and then by the concentration of inosinate. The conversion of inosinate to adenylate is limited by the concentration of aspartate. Adenylate conversion to guanylate is limited first by the concentration of glutamine and then probably by adenylate deaminase activity. Guanylate conversion to adenylate is limited by guanylate reductase activity.
The effects of cocoa on the immune system (2013)

Cocoa is a food relatively rich in polyphenols, which makes it a potent antioxidant. Due to its activity as an antioxidant, as well as through other mechanisms, cocoa consumption has been reported to be beneficial for cardiovascular health, brain functions, and cancer prevention. Furthermore, cocoa influences the immune system, in particular the inflammatory innate response and the systemic and intestinal adaptive immune response. Preclinical studies have demonstrated that a cocoa-enriched diet modifies T cell functions that conduce to a modulation of the synthesis of systemic and gut antibodies. In this regard, it seems that a cocoa diet in rats produces changes in the lymphocyte composition of secondary lymphoid tissues and the cytokines secreted by T cells. These results suggest that it is possible that cocoa could inhibit the function of T helper type 2 cells, and in line with this, the preventive effect of cocoa on IgE synthesis in a rat allergy model has been reported, which opens up new perspectives when considering the beneficial effects of cocoa compounds. On the other hand, cocoa intake modifies the functionality of gut-associated lymphoid tissue by means of modulating IgA secretion and intestinal microbiota. The mechanisms involved in these influences are discussed here. Further research may elucidate the cocoa compounds involved in such an effect and also the possible medical approaches to these repercussions.
An Italian Artificial Horizon (1944)

AT this stage of the war it is most unusual for any considerable novelty to be discovered in the design of aircraft instruments. In particular this applies to the Artificial Horizon, whose use is almost universal, and all instruments of this type are usually a close copy of the standard Spcrry instrument. The Italian Artificial Horizon described in this article does, however, incorporate a number of new and novel features; for example, the indicating mechanism has complete freedom in both pitch and roll instead of the customary limited range of movement. Some general details are:
Prostate Cancer Horizons in the Development of Novel Anti-Cancer Strategies (2001)

Prostate cancer is the most common cause of non-cutaneous cancer in men and a leading lethal malignancy with increasing incidence worldwide. Inevitably, all patients will develop androgen-independent disease, which remains the main obstacle to improving survival. Unfortunately, existing first and second line hormonal treatment are condemned to extent survival for only a few years. These sobering data have forced researchers to start exploring in depth the molecular mechanisms implicated in the emergence of androgen independence and of prostate cancer invasion. In this vein, epoch-making discoveries in molecular oncology along with rapid expansion of our knowledge concerning the processes that govern differentiation, apoptosis, immune surveillance, angiogenesis, metastasis, cell cycle and signal transduction control, have unveiled a plethora of specific targets for prostate cancer gene therapy, immunotherapy and anti-invasion therapy, along with a variety of small-molecule compounds which inhibit or stimulate these pathways. These new anti-cancer approaches are in various stages of clinical development, providing exciting perspectives for the future of prostate cancer cure and enriching the current anti-cancer drug quiver with a new spectrum of therapeutic agents. The present review, through extensive literature cross-examination, discusses several novel anti-prostate cancer strategies, emphasizing on approaches that potentially may extend end-stage patient's survival.
Signalling analysis in integrated 4G networks (2005)

Abstract Scarce radio resources and the ambition to increase the number of mobile customers with a guarantee of service are pushing mobile communication systems from homogeneous non‐service convergent 2G and convergent‐service 2.5G and 3G wireless systems to heterogeneous integrated and convergent service 4G networks. This evolution has had several consequences from network design, control and service management points of view. In the emerging integrated 4G networks one of the issues is the signalling of information related to different control purposes such as QoS, mobility and security signalling. In fact, some questions such as which are the candidate signalling protocols, and which approach of integrated signalling to be adopted (unified versus non‐unified) need to be considered in the context of the emerging 4G integrated network. This is precisely the scope of this paper. We first identify the requirements related to mobility, security/AAA and QoS signalling, then we consider candidate signalling protocols and we propose possible approaches in the integration of signalling in the context of 4G networks. Copyright © 2006 John Wiley & Sons, Ltd.
Chapter 1. Introduction (2007)

This chapter introduces the second edition of Design and Operation of Farm Irrigation Systems. The distribution and development of irrigation in the United States and throughout the world is reviewed. Issues facing irrigated agriculture including environmental concerns, sustainability, and changes in water policy are discussed. The chapter concludes with a discussion of options for future directions and some needs for irrigation research and education.
Expression of Neuroserpin, an Inhibitor of Tissue Plasminogen Activator, in the Developing and Adult Nervous System of the Mouse (1997)

Neuroserpin is a serine protease inhibitor of the serpin family that has been identified as an axonally secreted glycoprotein in neuronal cultures of chicken dorsal root ganglia. To obtain an indication for possible functions of neuroserpin, we analyzed its expression in the developing and the adult CNS of the mouse. In the adult CNS, neuroserpin was most strongly expressed in the neocortex, the hippocampal formation, the olfactory bulb, and the amygdala. In contrast, most thalamic nuclei, the caudate putamen, and the cerebellar granule cells were devoid of neuroserpin mRNA. During embryonic development, neuroserpin mRNA was not detectable in neuroepithelia, but it was expressed in the differentiating fields of most CNS regions concurrent with their appearance. In the cerebellum, the granule cells and a subgroup of Purkinje cells were neuroserpin-positive during postnatal development. As a further step toward the elucidation of neuroserpin function, we performed a study to identify potential target proteases. In vitro, neuroserpin formed SDS-stable complexes and inhibited the amidolytic activity of tissue plasminogen activator, urokinase, and plasmin. In contrast, no complex formation with or inhibition of thrombin was found. Expression pattern and inhibitory specificity implicate neuroserpin as a candidate regulator of plasminogen activators, which have been suggested to participate in the modulation or reorganization of synaptic connections in the adult. During development, neuroserpin may attenuate extracellular proteolysis related to processes such as neuronal migration, axogenesis, or the formation of mature synaptic connections.
Chronic pruritus: a paraneoplastic sign (2010)

Chronic itch could be a presenting sign of malignancy. Pruritus of lymphoma is the common prototype of paraneoplastic itch and can precede other clinical signs by weeks and months. Paraneoplastic pruritus has also been associated with solid tumors and is an important clinical symptom in paraneoplastic skin diseases such as erythroderma, Grovers disease, malignant acanthosis nigricans, generalized granuloma annulare, Bazex syndrome, and dermatomyositis. In any case with high index of suspicion a thorough work-up is required. This review highlights the association between itch and malignancy and presents new findings related to pathophysiological mechanisms and the treatment of itch associated with malignancy. Combinative therapies reducing itch sensitization and transmission using selective serotonin and neuroepinephrine reuptake inhibitors, Kappa opioids, and neuroleptics are of prime importance in reducing this bothersome symptom.
The effect of traps at the free surface of GaAs field effect transistors (1996)

In a GaAs field effect transistor there are ungated sections of the channel between the gate and the source/drain. The static characteristics and the transients which occur in various parameters after a change in the bias voltages can be shown to be affected by the surface potential in this region. A model is proposed for these effects which involves a surface region with lower effective energy gap. The gate current leakage characteristics and conductance deep level transient spectroscopy measurements on single and dual gate devices are consistent with this model.
Improved TLS Handshake Protocols Using Identity-Based Cryptography (2009)

Transport layer security (TLS) protocol is widely used in e-business and information systems for providing security attributes such as authentication, confidentiality and integrity. However, the certificate-based mechanism which is adopted by most TLS handshake protocols results in complex certificate management overheads and long handshake latency. To overcome these disadvantages, a series of handshake protocols were presented that applies identity-based encryption, signature, signcryption, and authenticated key agreement schemes respectively. Security analysis indicates that the identity-based protocols have equivalent security level but more security attributes than the standard certificate-based schemes and the ones proposed in the literature so far. Experiment results show that our schemes have commensurate cryptographic computation overheads comparing with other schemes, but achieve shorter handshake latency especially in bandwidth-limited environments because of less communication traffic.
Real-time audio multicasting on bluetooth network (2009)

Bluetooth has been deployed in many mobile devices nowadays which still lacking of real-time multicast support. In this paper, the real-time audio multicasting protocol has been proposed by using Piconet multicast partitioning and prioritization with BNEP broadcasting scheme in the ACL link. The simulation results show that the system throughput aggregation has been increased. Also the delay and inter-packet time are significantly decreased.
A middleware for fast and flexible sensor network deployment (2006)

A key problem in current sensor network technology is the heterogeneity of the available software and hardware platforms which makes deployment and application development a tedious and time consuming task. To minimize the unnecessary and repetitive implementation of identical functionalities for different platforms, we present our Global Sensor Networks (GSN) middleware which supports the flexible integration and discovery of sensor networks and sensor data, enables fast deployment and addition of new platforms, provides distributed querying, filtering, and combination of sensor data, and supports the dynamic adaption of the system configuration during operation. GSN's central concept is the virtual sensor abstraction which enables the user to declaratively specify XML-based deployment descriptors in combination with the possibility to integrate sensor network data through plain SQL queries over local and remote sensor data sources. In this demonstration, we specifically focus on the deployment aspects and allow users to dynamically reconfigure the running system, to add new sensor networks on the fly, and to monitor the effects of the changes via a graphical interface. The GSN implementation is available from http://globalsn.sourceforge.net/.
Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health (2022)

Flavonoids are natural phytochemicals that have therapeutic effects and act in the prevention of several pathologies. These phytochemicals can be found in seeds, grains, tea, coffee, wine, chocolate, cocoa, vegetables and, mainly, in citrus fruits. Neohesperidin, hesperidin and hesperetin are citrus flavonoids from the flavanones subclass that have anti-inflammatory and antioxidant potential. Neohesperidin, in the form of neohesperidin dihydrochalcone (NHDC), also has dietary properties as a sweetener. In general, these flavanones have been investigated as a strategy to control bone diseases, such as osteoporosis and osteoarthritis. In this literature review, we compiled studies that investigated the effects of neohesperidin, hesperidin and its aglycone, hesperetin, on bone health. In vitro studies showed that these flavanones exerted an antiosteoclastic and anti- inflammatory effects, inhibiting the expression of osteoclastic markers and reducing the levels of reactive oxygen species, proinflammatory cytokines and matrix metalloproteinase levels. Similarly, such studies favored the osteogenic potential of preosteoblastic cells and induced the overexpression of osteogenic markers. In vivo, these flavanones favored the regeneration of bone defects and minimized inflammation in arthritis- and periodontitis-induced models. Additionally, they exerted a significant anticatabolic effect in ovariectomy models, reducing trabecular bone loss and increasing bone mineral density. Although research should advance to the clinical field, these flavanones may have therapeutic potential for controlling the progression of metabolic, autoimmune or inflammatory bone diseases.