gebhart/patrepeval huggingface dataset:
Three‐Dimensional Ordered Arrays of 58×58×58 Å<sup>3</sup> Hollow Frameworks in Ionic Crystals of M<sub>2</sub>Zn<sub>2</sub>‐Substituted Polyoxometalates (2012)

Große Hohlräume: Eine einstufige Selbstorganisation von γ-Keggin-Silicowolframaten vom Sandwichtyp mit M2Zn2-Kernen (M=Co, Ni, Zn) und Tetrabutylammonium-Kationen liefert poröse ionische Kristalle. Sie bestehen aus einem Gerüst mit großen Hohlräumen (ca. 38×38×38 Å3, siehe Bild), zwischen denen Gastmoleküle über die verbindenden Kanäle ausgetauscht werden können. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
β-Sitosterol From Psyllium Seed Husk (Plantago ovata Forsk) Restores Gap Junctional Intercellular Communication in Ha-ras Transfected Rat Liver Cells (2005)

We purified compounds from the husks of psyllium seeds (Plantago ovata Forsk; desert Indian wheat), beginning with an ethanol extraction then followed by HP-20 and silica gel chromatography, which restored gap junctional intercellular communication (GJIC) in v-Ha-ras transfected rat liver epithelial WB-F344 cell line (WB-Ha-ras). GJIC was assessed by a scrape loading dye transfer assay. The active compound was identified as beta-sitosterol based on gas chromatography retention times and electron ionization mass spectroscopy (EI-MS) spectrum of authentic beta-sitosterol. Authentic beta-sitosterol restored GJIC in the tumorigenic WB-Ha-ras GJIC-deficient cells at a dose of 2.4 microM. In addition, a similar phytosterol, stigmasterol, also restored GJIC, albeit at a lower activity. beta-sitosterol and stigmasterol increased the level of connexin43 protein (Cx43) and restored phosphorylation of Cx43 to levels similar to the parental nontransfected cell line. We concluded that the restoration of intercellular communication in the GJIC-deficient, tumorigenic WB-Ha-ras cell line by the ethanol soluble fraction of psyllium seed husks is largely due to the presence of the phytosterol, beta-sitosterol. We discuss implications for dietary modulation of cancer by beta-sitosterol.
Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test (2014)

Patients on maintenance HD for several years may experience improvement of their liver function. However, a single HD session does not affect liver function significantly as assessed by the GSP test. Since the metabolism of galactose is dependent on liver blood flow and hepatic functional mass, further studies are needed.
Properties of nearly one-electron molecules. I. An iterative Green function approach to calculating the reaction matrix (2005)

An ab initio R-matrix method for determining the molecular reaction matrix of scattering theory is introduced. The method makes use of a principal-value Green function to compute the collision channel wave functions for the scattered electron, in combination with the Kohn variational scheme for the evaluation of R-matrix eigenvalues on a spherical boundary surface at short range. This technique permits the size of the bounded volume in the variational calculation to be reduced, making the computations fast and efficient. The reaction matrix is determined in a form that minimizes its energy dependence. Thus the procedure does not require modification or an increase in the computational effort to study the electronic structure and dynamics in Rydberg molecules with extremely polar ion cores. The analysis is specialized to examine the bound-state and free-electron scattering properties of nearly one-electron molecular systems, which are characterized by a Rydberg/scattering electron incident on a closed-shell ion core. However, it is shown that the treatment is compatible with all-electron/ab initio representations of open-shell and nonlinear polyatomic ion cores, emphasizing its generality. The introduced approach is used to calculate the electronic spectrum of the calcium monofluoride molecule, which has the extremely polar (Ca+2F-)+e- closed-shell ion-core configuration. The calculation utilizes an effective single-electron potential determined by M. Arif, C. Jungen, and A. L. Roche [J. Chem. Phys. 106, 4102 (1997)] previously. Close agreement with experimental data is obtained. The results demonstrate the practical utility of this method as a viable alternative to the standard variational approaches.
Effect of annealing on forming limit diagram and crystallographic textures of aluminium 5086 grades annealed at four different temperatures (2009)

The crystallographic texture and formability of aluminium alloy 5086 annealed at 160, 200, 250 and 300°C have been studied. Experimentally determined forming limit diagrams (FLDs) for the above said Al 5086 sheets, their crystallographic textures and their orientation distribution function plots made by X-ray diffraction were analysed. The present study shows a comparison between these FLDs of Al 5086 sheets and the corresponding result of crystallographic texture analysis. The FLDs and crystallographic textures were then correlated with normal anisotropy of the sheet metal. It was found that aluminium alloy 5086 annealed at 300°C possessed good formability, preferred texture and high normal anisotropy value.
The RNA-binding protein HF-I, known as a host factor for phage Qbeta RNA replication, is essential for rpoS translation in Escherichia coli. (1996)

The rpoS-encoded sigma(S) subunit of RNA polymerase in Escherichia coli is a global regulatory factor involved in several stress responses. Mainly because of increased rpoS translation and stabilization of sigma(S), which in nonstressed cells is a highly unstable protein, the cellular sigma(S) content increases during entry into stationary phase and in response to hyperosmolarity. Here, we identify the hfq-encoded RNA-binding protein HF-I, which has been known previously only as a host factor for the replication of phage Qbeta RNA, as an essential factor for rpoS translation. An hfq null mutant exhibits strongly reduced sigma(S) levels under all conditions tested and is deficient for growth phase-related and osmotic induction of sigma(S). Using a combination of gene fusion analysis and pulse-chase experiments, we demonstrate that the hfq mutant is specifically impaired in rpoS translation. We also present evidence that the H-NS protein, which has been shown to affect rpoS translation, acts in the same regulatory pathway as HF-I at a position upstream of HF-I or in conjunction with HF-I. In addition, we show that expression and heat induction of the heat shock sigma factor sigma(32) (encoded by rpoH) is not dependent on HF-I, although rpoH and rpoS are both subject to translational regulation probably mediated by changes in mRNA secondary structure. HF-I is the first factor known to be specifically involved in rpoS translation, and this role is the first cellular function to be identified for this abundant ribosome-associated RNA-binding protein in E. coli.
‘ <i>Candidatus</i> Lumbricincola’, a novel lineage of uncultured <i>Mollicutes</i> from earthworms of family <i>Lumbricidae</i> (2009)

Molecular signatures of new, as yet uncultured mollicute-like organisms (MLOs) have been detected in total rRNA and DNA extracted from tissues, gut contents and casts of four species of the earthworm family Lumbricidae. The MLO 16S rRNA sequences exhibited low identity to those of known Mollicutes species and formed a monophyletic cluster distantly affiliated to the 'Candidatus Bacilloplasma' (84.9%) and almost equidistant to the other main phylogenetic group of Mollicutes (< 79.8%) and the classes Bacilli (< 79.5%) and Clostridia (< 76.1%). SSCP profiling and sequence analysis of bands and bacterial clones derived from the earthworms and substrata revealed high phylogenetic relatedness of MLOs in earthworms from different geographic locations (Russia and Germany), with no obvious host species specificity being observed. Fluorescence in situ hybridization (FISH) analysis with a nucleotide probe specific for the new MLO group localized them to the coelomic fluids of earthworms. A new taxonomic group within the Mollicutes, designated 'Candidatus Lumbricincola', is proposed to include these as yet uncultured organisms.
Quenching of the Radio Jet during the X-Ray High State of GX 339−4 (1999)

We have observed the black hole candidate X-ray binary GX 339-4 at radio wavelengths before, during and after the 1998 high/soft X-ray state transition. We find that the radio emission from the system is strongly correlated with the hard X-ray emission and is reduced by a factor > 25 during the high/soft state compared to the more usual low/hard state. At the points of state transition we note brief periods of unusually optically-thin radio emission which may correspond to discrete ejection events. We propose that in the low/hard state black hole X-ray binaries produce a quasi-continuous outflow, in the high/soft state this outflow is suppressed, and that state transitions often result in one or more discrete ejection events. Future models for low/hard states, such as ADAF/ADIOS solutions, need to take into account strong outflow of relativistic electrons from the system. We propose that the inferred Comptonising corona and the base of the jet-like outflow are the same thing, based upon the strong correlation between radio and hard X-ray emission in GX 339-4 and other X-ray binaries, and the similarity in inferred location and composition of these two components.
A modular phosphate tether-mediated divergent strategy to complex polyols (2014)

An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple "order of addition" of a pair of olefinic-alcohol components to a pseudo-C 2-symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.
Faculty Opinions recommendation of Coding of pleasant touch by unmyelinated afferents in humans. (2009)

Pleasant touch sensations may begin with neural coding in the periphery by specific afferents. We found that during soft brush stroking, low-threshold unmyelinated mechanoreceptors (C-tactile), but not myelinated afferents, responded most vigorously at intermediate brushing velocities (1-10 cm s(-1)), which were perceived by subjects as being the most pleasant. Our results indicate that C-tactile afferents constitute a privileged peripheral pathway for pleasant tactile stimulation that is likely to signal affiliative social body contact. PMID: 19363489
ChemInform Abstract: The Generation of 2,3‐Dihydro‐2,3‐bis(methylene)thiophenes from 4,6‐Dihydrothieno(3,4‐b)thiophene 5,5‐Dioxides. (1990)

Abstract Heating of the dihydrothienothiophene dioxides (I) in sulfolane up to 200°C yields the intermediates (II) which in situ undergoes Diels‐Alder reaction with the dienophiles (III), (V), and (VII) to give the cycloadducts (IV), (±)‐(VI), and (VIII) respectively.
ChemInform Abstract: MAGNETIC ISOTOPE AND MAGNETIC FIELD EFFECTS ON CHEMICAL REACTIONS. SUNLIGHT AND SOAP FOR THE EFFICIENT SEPARATION OF CARBON‐13 AND CARBON‐12 (1979)

Abstract In homogenem Benzol zeigt die photochemische Decarbonylierung von Dibenzylketon eine geringe aber meß‐ bare "C/"C‐Trennung, die stark zunimmt, wenn Hexadecyltrimethylammoniumchlorid zugesetzt wird.
Effect of mitomycin c and 5‐flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation (2016)

Adjuvant treatment with antifibrotics following Ahmed glaucoma valve implantation decreased the hypertensive phase and improved surgical outcomes without impacting complication rates at 1 year. This study postulates a role for antifibrotics in the postoperative management of Ahmed glaucoma valves.
Calibration of the Forward-scattering Spectrometer Probe: Modeling Scattering from a Multimode Laser Beam (1993)

Scattering calculations using a more detailed model of the multimode laser beam in the forward-scattering spectrometer probe (FSSP) were carried out by using a recently developed extension to Mie scattering theory. From this model, new calibration curves for the FSSP were calculated. The difference between the old calibration curves and the new ones is small for droplet diameters less than 10 µm, but the difference increases to approximately 10% at diameters of 50 µm. When using glass beads to calibrate the FSSP, calibration errors can be minimized, by using glass beads of many different diameters, over the entire range of the FSSP. If the FSSF is calibrated using one-diameter glass beads, then the new formalism is necessary to extrapolate the calibration over the entire range.
Study of spin-lattice relaxation of ytterbium ions in glasses (1996)

The experimental and theoretical study of electron spin-lattice relaxation of Yb<SUP>3+</SUP> ions in phosphate glasses was performed. Measurements were made with electron spin echo method. Some dependencies of the relaxation on the temperature, concentration, and sample dimension are supposed to be caused by localized vibrational states.
Nanoglue: An Alternative Way To Display Cell-Internalizing Peptide at the Spikes of Hepatitis B Virus Core Nanoparticles for Cell-Targeting Delivery (2012)

Cell-internalizing peptides (CIPs) can be used to mediate specific delivery of nanoparticles across cellular membrane. The objective of this study was to develop a display technique using hepatitis B virus (HBV) capsid-binding peptide as a "nanoglue" to present CIPs on HBV nanoparticles for cell-targeting delivery. A CIP was selected from a phage display library and cross-linked specifically at the tips of the spikes of the HBV capsid nanoparticle via the "nanoglue" by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysulfosuccinimide (sulfo-NHS). Fluorescent oligonucleotides packaged in the nanoparticles and the fluorescein molecules conjugated on the nanoparticles were delivered to cells by using this display technique. This study demonstrated a proof of principle for cell-targeting delivery via "nanoglue" bioconjugation.
Selectivity of the Oxidative Attack on a Model Ester Lubricant (1977)

The relative oxidative attack at the various carbon-hydrogen bonds of the model ester lubricant neopentyl hexanoate at temperatures 150–200 C was determined by GLC analysis of appropriate derivatives. Relative rates for single carbon-hydrogen bonds were: primary I,“normal” secondary 15, alpha-acyl secondary 2, and alpha-alcohol secondary 4. These results may furnish valuable insight in the development of more oxidatively stable esters for use in high-temperature jet engine lubricants.
Tenascin is a stromal marker for epithelial malignancy in the mammary gland. (1987)

Tenascin is an extracellular matrix glycoprotein that is not present in the normal mature rat mammary gland. The distribution of tenascin was examined by immunohistochemistry in mammary tumors from carcinogen-treated and untreated rats, in virus-induced mammary tumors from mice, and in a variety of mammary gland lesions from humans. Tenascin was detectable in the stroma of the malignant but not of the benign tumors from all species. An inhibition ELISA, testing homogenates of rat tumors, confirmed that tenascin was present in malignant but not in benign tumors. Thus, tenascin was consistently found to be a stromal marker for epithelial malignancy in the mammary gland. It is concluded that tenascin may be involved in the interactions between the epithelial and mesenchyme-derived (stromal) components of the mammary gland, which are known to influence epithelial carcinogenesis in this organ.
Abstract 1172: Neointima Formation is Dependent on p38α Mitogen-Activated Protein Kinase (2007)

Neointima formation frequently occurs after arterial injury and is responsible for substantial human morbidity. We previously demonstrated that the intracellular linker protein Grb2 is required for neointima formation, and that Grb2 regulates p38α mitogen-activated protein kinase (MAPK) activation in vascular smooth muscle cells (SMCs). In this work, the role of p38α MAPK in neointima formation was examined. In vitro experiments showed that pharmacological inhibition of p38 MAPK activity in cultured SMCs blocked platelet-derived growth factor (PDGF)-stimulated DNA replication and cell proliferation. Specifically, in control SMCs, overnight stimulation with PDGF induced an 11.8-fold increase in thymidine incorporation and a 1.9 fold increase in cell number. However, inhibition of p38 MAPK activity reduced PDGF-induced thymidine incorporation to 2.8-fold (P = 0.0006) and completely blocked PDGF-stimulated cell proliferation (P = 0.0001). Also, p38 MAPK activity was required for PDGF-induced inactivation of the retinoblastoma tumor suppressor protein, Rb, and induction of mini-chromosome maintenance protein-6 (MCM6), a fundamental regulator of DNA replication. Next, compound transgenic mice were generated with doxycycline (Dox)-inducible, SMC-specific expression of a dominant-negative form of p38α MAPK (SMC-DN-p38α ). Dox induced robust expression of DN-p38α mRNA and protein in the aorta and carotid arteries of compound transgenic mice, and inactivation of native, arterial p38 MAPK. SMC-DN-p38α and single transgenic, control mice were subjected to carotid injury by use of an epoxy resin-beaded probe. After 21 days, control mice developed robust neointima formation that frequently resulted in an occlusive lesion with a mean neointima/media ratio of 2.62 (N = 8). In contrast, SMC-DN-p38α mice were resistant to the development of neointima. Specifically, neointima/media ratio was reduced to 0.63 for SMC-DN-p38α mice (N = 12; P = 0.045). In addition, compared to control mice, injured carotid arteries of SMC-DN-p38α mice showed defective p38 MAPK activation in SMCs of the tunica media. Our results demonstrate that vascular SMC p38α MAPK is required for neointima formation after arterial injury.
Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD (2016)

Peripheral blood eosinophil counts can help identify the presence or absence of sputum eosinophilia in stable COPD patients with a reasonable degree of accuracy.
Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3, and recombinant murine granulocyte/macrophage colony-stimulating factor. (1987)

Combinations of low dosages of purified murine hematopoietic colony-stimulating factors (CSFs)--L-cell CSF type 1 (CSF-1), recombinant interleukin 3 (IL-3), and recombinant granulocyte/macrophage CSF (GM-CSF)--were compared with single CSFs for their influence on the cycling rates and numbers of bone marrow granulocyte/macrophage, erythroid, and multipotential progenitor cells in vivo in mice pretreated with human lactoferrin. Lactoferrin was used to enhance detection of the stimulating effects of exogenously administered CSFs. Concentrations of CSFs that were not active in vivo when given alone were active when administered together with other types of CSF. The concentrations of CSF-1, IL-3, and GM-CSF needed to increase progenitor cell cycling rates were reduced by factors of 40-200, 10-50, and 40- greater than 400, respectively; the concentrations needed to increase progenitor cell numbers were reduced by factors of 40-500 (CSF-1), 20-80 (IL-3), and greater than 40- greater than 200 (GM-CSF) when these forms of CSFs were administered in combination with low dosages of one of the other forms of CSFs. The results demonstrate that different CSFs can synergize when administered in vivo to increase the cycling rates and numbers of marrow hematopoietic progenitor cells. These findings may be of relevance physiologically to the regulation of myeloid blood cell production by CSFs.
Oral topotecan demonstrates clinical activity in relapsed non-small cell lung cancer. Results from an open-label, phase III study (387) comparing oral topotecan to intravenous docetaxel (2005)

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Machine Learning for Rhetorical Figure Detection: More Chiasmus with Less Annotation (2017)

Figurative language identification is a hard problem for computers.In this paper we handle a subproblem: chiasmus detection.By chiasmus we understand a rhetorical figure that consists in repeating two elements in reverse order: "First shall be last, last shall be first".Chiasmus detection is a needle-in-the-haystack problem with a couple of true positives for millions of false positives.Due to a lack of annotated data, prior work on detecting chiasmus in running text has only considered hand-tuned systems.In this paper, we explore the use of machine learning on a partially annotated corpus.With only 31 positive instances and partial annotation of negative instances, we manage to build a system that improves both precision and recall compared to a hand-tuned system using the same features.Comparing the feature weights learned by the machine to those give by the human, we discover common characteristics of chiasmus.
2P1-A22 Wireless Signal Transmitting System Driven by Piezoelectric Generator (2008)

We propose a wireless signal transmitting system by gaining energy from the surroundings. As all of energy needed by this system is gained from the surroundings, there are no necessities for refilling fuel or changing battery. For example, Tire Pressure Monitoring System (TPMS) needs such a maintenance-free sensor system. The system consists of a piezoelectric generator, a capacitor, and a circuit. The circuit watches the capacitor's storage and supplies energy to the transmitter. We made an experiment to gain energy from the deformation of a car wheel with the generator. The energy from the environment is estimated to be about 20mW. This estimation shows that we can drive a transmitter for 1 second after 7 second's charge. We were also able to drive the transmitter in another environment from which the generator gains a little energy, so this system is available not only on wheel's surface but also in general environments.