gebhart/patrepeval huggingface dataset:
T lymphocyte subpopulations in chronic lymphocytic leukemia of B cell type in relation to immunoglobulin isotype(s) on the leukemic clone and to clinical features (1987)

Total blood T lymphocytes and subpopulations (OKT4+ and OKT8+ cells) were studied in 59 patients with B cell chronic lymphocytic leukemia (B-CLL). In 48 previously untreated patients, total T lymphocytes were higher as compared to healthy controls (p less than 0.001). T-cells and OKT8+ cells were significantly increased in patients in advanced clinical stage and with progressive disease in comparison to patients with low stage and indolent disease. High numbers of OKT8+ lymphocytes were also seen in patients with a dominance of mu heavy chains on the leukemic clone. Moreover, in this patient group the OKT8+ subpopulation correlated with total B cells (r = 0.68, p less than 0.001) while in patients with a mu delta phenotype no such correlation was seen. After successful cytostatic therapy there was a reduction in total numbers of both OKT4+ and OKT8+ cells, in particular, with a concomitant increase in OKT4/OKT8 ratios.
Clinical significance of hematologic parameters in non-Hodgkin's lymphoma at diagnosis (1991)

Three hundred seventeen patients with non-Hodgkin's lymphoma (NHL) (54 low grade, 180 intermediate grade, 76 high grade, and seven unclassified) treated with chemotherapy were evaluated for the presence of hematologic abnormalities at diagnostic staging. Anemia was present in 42%, leukopenia in 6%, thrombocytopenia in 13%, leukocytosis in 26%, and thrombocytosis in 14% at presentation. The presence of bone marrow involvement by lymphoma was more likely to be associated with leukopenia and thrombocytopenia than the absence of bone marrow involvement. Although anemia was slightly more common in patients with bone marrow lymphoma than in those without marrow lymphoma, the difference was not statistically significant. Hematologic parameters were similar for patients with B-cell or T-cell lymphoma. Evidence of bone marrow failure with multiple cytopenias was present in 26 patients (8%). Leukoerythroblastosis was present in 2%. Circulating lymphoma was present in 9.5%. Anemic patients had a shorter survival time than nonanemic patients, whether bone marrow was involved by lymphoma or not. Survival was not affected by the presence of leukopenia or mild leukocytosis, but, in patients without marrow lymphoma, leukocytosis with a leukocyte count greater than 20 x 10(9)/l was associated with short survival length. Thrombocytopenia was associated with short survival time only in patients with bone marrow involvement by lymphoma. Patients with multiple cytopenias or leukoerythroblastosis had short survival times, but the presence of circulating lymphoma did not alter survival when compared with other patients with bone marrow involvement by lymphoma. These data suggest that hematologic evaluation at the time of diagnostic staging of NHL provides useful prognostic information that may have therapeutic implications.
Discovery of Novel Adenylyl Cyclase Inhibitor by Cell-Based Screening (2014)

We screened 2400 compounds to find novel inhibitors of the adenylyl cyclase (AC)-protein kinase A (PKA)-cAMP response-element-binding protein (CREB) signaling pathway (AC/PKA/CREB pathway). Using a multistep cell-based screening system employing split luciferase technique, we narrowed down the candidates effectively from 2400 chemical compounds and identified a novel AC inhibitor (compound 1). Since dysregulation of the AC/PKA/CREB pathway is known to cause diseases not only in the nervous system but also in other organs, compound 1 is expected to be developed as a medicine for these diseases.
A General Method for the Axially Loaded Slender Bar (2011)

This chapter contains sections titled: Introduction Nodes, Elements, Shape Functions, and the Element Stiffness Matrix The Assembled Global Equations and Their Solution A General Method—Distributed Applied Loads Variable Cross Sections Analysis and Design of Pin-jointed Trusses Summary and Conclusions
An Approach to Gate Assignment and Module Placement for Printed Wiring Boards (1978)

High density packaging is one of the most urgent requirements in the design of digital systems. In the assembly of such systems, printed wiring boards (PWB's) are used very often to provide the necessary interconnection among circuit modules. Thus, methods to raise wiring density of PWB's are continually under investigation. Given a router to realize 100 percent wiring, an efficient method for assigning logical gates to circuit modules and for determining the placement of the modules on a given PWB may contribute more toward raising the wirability than improving the existing routing scheme, especially when all available sophisticated routing algorithms have been attempted. The present paper proposes an algorithm to the problem of gate assignment and module placement, to be added to an existing router. It operates on a PDP 11/40 with 24K words core memory and 1.2M words disk storage coupled with a TEKTRONIX 4014 graphics terminal. We also show how effectively the described assignment and placement scheme improves the wirability of the router.
The deposition and planarization of a conformal, 300 degrees C APCVD interlevel dielectric (2003)

Borosilicate glasses (BSGs) produced from atmospheric pressure chemical vapor deposition (APCVD) systems are shown to be suitable for practical multilevel metal interlevel dielectric applications. A batch hot-plate reactor produced films at 300 degrees C at a deposition rate of 700 AA/min, film thickness uniformity +or-4%, a compressive stress of 1*10/sup +9/ dynes/cm/sup 2/, and a step coverage conformality of 0.8. The APCVD BSG also has advantages for sacrificial spin-on-glass (SOG) etchback planarization processes. Its dry etch rate is 1.3 times that of thermal oxide which makes matching SOG etch rates easier, and the redeposited film has the ability to fill small crevices to provide a smooth surface for metallization step coverage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adaptation Techniques for Electronic Equalizers for the Mitigation of Time-Variant Distortions in 43 Gbit/s Optical Transmission Systems (2007)

Adaptation techniques for an adaptive 43 Gbit/s electronic equalizer using either the FEC error count or the output of a novel integrated electronic eye monitor as feedback signal have been compared experimentally for the first time.
A new method for shear wave logging (1980)

Abstract Reliable evaluation of shear (S) wave characteristics in boreholes may be facilitated by the system proposed here, in a wide variety of geologic conditions and depths. The measurements can be done with a sonde, suspended freely in water contained in a borehole. The main part of the sonde consists of a source, a filter tube, and receivers.In this system, the wave field is treated approximately as that in an infinite homogeneous solid medium, because the wavelength is sufficiently longer than the borehole diameter. The source behaves as a single point force. The direct S-wave is detected on a line (borehole axis) perpendicular to the force axis, in which predominant radiation of shear wave is expected. This fact is completely different from some modified systems of sonic log, in which 'shear wave' is the converted-refracted wave propagating as the shear wave along a borehole wall.The proposed source system is the 'indirect-excitation type,' wherein the force is applied to a borehole wall indirectly through a pressure distribution of doublet-type excited in the water. Based on its principle, this source system eliminates generation of dilatational noise waves and also assures operation at greater depths because no work is done against the external pressure, as a whole, at the source.The proposed receiver system is the suspension type, wherein horizontal motion of the borehole wall (ground motion of S-wave) is detected through corresponding water motion by a detector of neutral buoyancy.The fundamental applicability of this logging system was confirmed by experiments at shallow depths.
A Double-blind Placebo-controlled Case Study of the Use of Donepezil to Improve Cognition in a Schizoaffective Disorder Patient: Functional MRI Correlates. (2001)

Cognitive impairment in multiple domains is common in patients with schizophrenia and may be a powerful determinant of poor functional ability and quality of life. We report a double-blind, placebo-controlled, cross-over study of donepezil augmentation in a schizoaffective disorder patient stabilized on olanzapine pharmacotherapy. The patient showed significant improvements in several cognitive measures and increased activation of prefrontal cortex and basal ganglia on functional MRI during the donepezil augmentation. In addition, the donepezil augmentation resulted in a reduction of depressive symptoms and in significant improvements in functional abilities and quality of life. Further studies of donepezil augmentation of neuroleptics in schizophrenia are warranted.
Low-Loss, Narrow-Band SAW Filters on Leaky Substrates (2007)

Surface acoustic wave filters operating at 1.6 GHz (GPS range) on 42deg-LiTaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> are presented. The design is based on strong localized acoustical resonances appearing in gaps between long interdigital transducers. Realized low-loss filter has a fractional bandwidth of ~2% with a low insertion loss (~1 dB in the passband) and high rejection levels. We present also a switchable variant with response corresponding to that of two filter tracks connected electrically in series.
Lanthanum blockade of serotonin release from the branchial nerve of the mussel <i>Mytilus edulis</i> (1980)

The study demonstrates that lanthanum at low levels (5 mM) can block the neuronal release of serotonin. In addition, the postlateral ciliated cell serotonergic receptor is not affected by this blockade at this particular concentration of lanthanum, but is affected at higher levels (10 mM).
Morbus Teutschländer im Bereich der Schulter als seltene Differenzialdiagnose zur Tendinosis calcarea – ein Fallbericht (2003)

Einleitung: Der Morbus Teutschländer (tumorale Kalzinose) ist eine sehr seltene Form der benignen Weichteilkalzifizierung. Wir beschreiben einen Fall des M. Teutschländer im Bereich des M. supraspinatus als interessante Differenzialdiganose zur Tendinosis calcarea.
ChemInform Abstract: PHOTOCHEMISTRY OF 1,4‐DIPHENYL‐1,4‐EPOXY‐1,4‐DIHYDRONAPHTHALENE‐2‐CARBOXYLATE AND ‐2,3‐DICARBOXYLATE ESTERS (1977)

Abstract Bei direkter Bestrahlung der Ester (I) entstehen die Benzoxepine (II), die Indene (III) und ‐ neben (IIa) und (IIIa) ‐ auch das Inden (IV).
Evaluation of $sup 51$Cr as a leucocyte label (1973)

A double label technique was developed to compare the behavior of /sup 51/Cr-labelled leucocytes with DF/sup 32/P labelled leucocytes. Whole blood is divided into two aliquots and the leucocytes in each are labelled with a different isotope. After infusion of labelled cells, the radioactivity of each isotope can be determined simultaneously on the same blood sample using liquid scintillation counting. In studies of seven patients with solid tumours and one with leukemia, the intravascular disappearance of autologous leucocytes labelled with /sup 51/Cr and DF/sup 32/P appeared similar in five of the eight patients during the initial 6 hr following infusion. Thereafter in all but one instance, / sup 51/Cr labelled leucocytes had slightly higher specific activities. Chromium- 51-labelled lymphocytes and DF/sup 32/P labelled lymphocytes also behaved in the same manner. It is concluded that /sup 51/Cr is a suitable leucocyte label and may be substituted for DF/sup 32/P under certain circumstances. (UK)
ENHANCEMENT OF DRIVE-MODE BANDWIDTH IN MEMS VIBRATORY GYROSCOPES UTILIZING MULTIPLE OSCILLATORS (2004)

The limitations of photolithography-based micromachining technologies defines the upper-bound on the performance and robustness of micromachined gyroscopes. Conventional gyroscope designs based on matching the drive and sense modes are extremely sensitive to variations in system parameters. Non-conventional design concepts have been reported that increase bandwidth to improve robustness, but with the expense of response gain reduction. This paper presents a new approach that may yield vibratory MEMS gyroscopes with wider drive-mode bandwidth, without significant sacrifice in response gain. The approach is based on utilizing multiple drive-mode oscillators with incrementally spaced resonant frequencies to achieve wide-bandwidth response in the drive-mode. Enhanced mode-decoupling is also achieved by distributing the linear drive-mode oscillators radially and symmetrically, to form a multi-directional linear drive-mode and a torsional sense-mode; minimizing quadrature error and zero-rate-output. The approach has been implemented on bulk-micromachined prototypes fabricated in a SOI-based process, and experimentally demonstrated.
Extended tuning and spatial chirp compensation in noncollinear PPKTP OPO in the red spectral region (2001)

Summary form only given. A potentially very efficient strategy of generating red light for different applications is by using parametric down-conversion of frequency-doubled radiation from widely available Nd/sup 3+/-doped lasers. In this work we demonstrate efficient generation of mJ level signal in the visible OPO employing periodically poled KTiOPO/sub 4/ (KTP).
Effects of tuftsin on postsplenectomy sepsis. (1985)

Tuftsin is a tetrapeptide within the CH2 domain of the IgG immunoglobulin. Enzymatically cleaved from its parent globulin, it increases the phagocytic activity of macrophages, monocytes, and neutrophils by specific receptor mechanisms. In splenectomized hosts the circulating levels of tuftsin are reduced. Postsplenectomy sepsis is due to impaired clearance of intravascular bacteria; it has been postulated that tuftsin deficiency may contribute to this impairment. In this experiment splenectomized DBA/2 mice were subjected to pneumococcal sepsis. The groups of mice treated with tuftsin and those that received autotransplanted splenic tissue had significantly improved survival rates. We conclude that tuftsin deficiency plays a role in postsplenectomy sepsis and that treatment with synthetic tuftsin protects the splenectomized host against pneumococcal septic death.
Neutron diffraction structural study of Ce2Fe17−<i>x</i>Ga<i>x</i> (1996)

Six samples of Ce2Fe17−xGax with nominal Ga content x equal to 0, 0.3, 0.5, 0.7, 1.0, 2.0 have been studied by powder neutron diffraction at room temperature. Both crystalline and magnetic refinements have been carried out. All six samples adopt the Th2Zn17-type rhombohedral structure. The only additional phase found is α-iron. Gallium atoms are found to have high affinity for the iron 18h site, and are absent from the 9d and 18f sites. The Ga substitution for Fe leads to an expansion of both the a and c axes. The Curie temperature increases from 238 K for Ce2Fe17 to 406 K for Ce2Fe15Ga2. Magnetic refinements on the samples with x=0.3, 0.5, 0.7, 1.0, and 2.0 reveal that the magnetic moments of the four Fe sites are in the basal plane and that their values increase with increasing Ga content.
Effect of Perovskite Coating on Oxide Scale Growth on Fe-22Cr (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
[Early failure in kidney transplantation]. (1991)

Parameters of early failure in kidney transplantation have been analyzed from 507 transplantations with transplant loss in the first month, selected among the 7541 cadaveric kidney transplantations performed in France between 1985 and 1989. These failures represent 6.7 percent of the population transplanted over this period of time, 68.6 percent of the failures that occurred in the first 3 months post-grafting, and 47 percent of the total number of the first year failures. Comparing patients with and without transplant failure in the first month, sex of the donor and the recipient, ABO group of the donor and the recipient, origin of the kidney, cold ischemia time, HLA compatibility, dialysis duration, number of previous transplantations, showed no influence on the occurrence of early failure. Three parameters appeared to be significant risk factors: donor's age less than 5 years, P = 0.00001; recipient's age less than 5 years, P = 0.05; pregraft immunization, P = 0.002. Furthermore, multifactorial analysis showed that the absence of HLA compatibilities between donor and recipient in hyperimmunized patients also has a significant influence on early graft loss. However, comparison of these same parameters in patients with transplant failure within the first month and between 2 and 12 months post-grafting revealed that the influence of these 4 significant parameters is longstanding and that none of them is specific of the precocity of graft loss.
Temperature dependence of the unit-cell parameters of double perovskite-type Ba 2 NdSn 0.6 Sb 0.4 O 6- (2011)

Temperature dependence of the unit-cell parameters of double perovskite-type Ba2NdSn0.6Sb0.4O6- ○Hiroki Kato*, Masatomo Yashima***, Paul J. Saines***, Brendan J. Kennedy*** * Department of Materials Science and Engineering, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, Nagatsuta-cho 4259, Midori-ku, Yokohama, 226-8502, Japan ** Department of Chemistry and Materials Science, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1-W4-17, O-okayama, Meguro-ku, Tokyo, 152-8551, Japan ***School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
Calculation of the specific and volumetric enthalpies of Ge-Si alloys (1988)

A procedure is developed for the calculation of specific and volumetric enthalpies of Ge-Si alloys as an initial step in the evaluation of these materials for heat storage in solar dynamic power systems. The calculation is based on the thermodynamics of non-ideal solutions and the reported /open quotes/regular/close quotes/ nature of liquid and solid Ge-Si solutions. With only minor modifications, all of the other thermodynamics properties of this alloy system may additionally be evaluated. Use of Ge-Si alloys for heat storage purposes in solar receivers entails both negative and positive aspects. The negative aspects relate largely to the non-congruent nature of the phase change process which precludes isothermal heat delivery. However, on the positive side are high thermal conductance, low volume change on melting, and the availability of a range of heat delivery temperatures by modification of only the alloy composition.
Effect of ginseng principle on pyruvate kinase activity in rat liver. (1979)

In comparing the effect of ginseng principle on the activity of pyruvate kinase (EC 2. 7. 1. 40), there was a marked difference among various diet groups. Administration of the extract (fraction 5) from the roots of Panax ginseng C. A. MEYER increased the activity of hepatic pyruvate kinase in rats fed on a laboratory pellet chow. Maximum increase in the enzyme activity was observed 1 hr after the administration of ginseng principle, and it was found that this response depended on the amount of fraction 5 administered to rats. However, rise of the enzyme activity due to ginseng treatment did not seem to involve de novo protein synthesis which requires mRNA production. In contrast, when the diet contained an excess of carbohydrate, ginseng treatment resulted in a decreased enzyme level, and the elimination of food resulted in the loss of the effect of ginseng principle.
Generation of Singlet Molecular Oxygen in Rat Liver Homogenate on Adding Autoxidized Linseed Oil (1981)

The light-emitting species of chemiluminescence produced in rat liver homogenate on adding autoxidized linseed oil (AOLO) were investigated. The chemiluminescent intensity of liver homogenate was strongly enhanced by the addition of AOLO and showed a proportional relationship to the amount of AOLO. The chemiluminescence was reduced with singlet oxygen (1O2) quenchers and free radical scavengers. Among them, β-carotene showed the most effective quenching. The emission spectrum had broad bands in the visible region with eminent chemiluminescent lines at 520, 575 and 640 nm due to the simultaneous transition, . An additional weak line was found at 480 nm corresponding to . In the presence of β-carotene, lines corresponding to the simultaneous transition of 1O2 disappeared. These results indicate that the liver homogenate with AOLO generated singlet molecular oxygen as one of the major light-emitters of the chemiluminescence. A possible mechanism for the generation of 1O2 is by decomposition of peroxy radicals derived from AOLO in the liver homogenate.
Thermoelectric properties of Si1−xGex(x⩽0.10) with alloy and dopant segregations (2000)

The thermal conductivity κ and the thermoelectric properties of Si1−xGex(x⩽0.10) samples doped with B or P which were prepared by arc melting were measured as functions of carrier concentration n and temperature T in the range from 298 to 1273 K. The Si1−xGex(0.03⩽x⩽0.10) samples, doped with a small amount of B or P, have a significantly low κ value, less than one tenth that of pure Si, despite the presence of strong alloy and dopant segregations. The Seebeck coefficients S of the Si0.97Ge0.03 samples over the entire n range from 1018 to 1021 cm−3 were higher than the corresponding values of Si0.7Ge0.3 alloys with little segregation, although the difference between the electrical resistivities ρ of our samples and their alloys is very small. The optimum n value giving the largest thermoelectric figures of merit (ZT=S2T/κρ) for n- and p-type Si0.97Ge0.03 samples was about 2×1020 cm−3, which is almost the same as that for Si0.7Ge0.3 alloys. At n≒2×1020 cm−3 the ZT values of n- and p-type Si0.95Ge0.05 samples with segregation increase linearly with temperature, and become 0.90 and 0.57 at 1073 K, respectively, which corresponds to 92% and 81% of the ZT values for Si0.7Ge0.3 alloys with little segregation.
Two Dimensional Processing Of Speech And Ecg Signals Using The Wigner-Ville Distribution (1986)

The Wigner-Ville Distribution (WVD) has been shown to be a valuable tool for the analysis of non-stationary signals such as speech and Electrocardiogram (ECG) data. The one-dimensional real data are first transformed into a complex analytic signal using the Hilbert Transform and then a 2-dimensional image is formed using the Wigner-Ville Transform. For speech signals, a contour plot is determined and used as a basic feature. for a pattern recognition algorithm. This method is compared with the classical Short Time Fourier Transform (STFT) and is shown, to be able to recognize isolated words better in a noisy environment. The same method together with the concept of instantaneous frequency of the signal is applied to the analysis of ECG signals. This technique allows one to classify diseased heart-beat signals. Examples are shown.