gebhart/patrepeval huggingface dataset:
Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing dogs (2006)

Intravenously administered docetaxel (DT) is problematic in cats because of the requirement for premedication to ameliorate acute vehicle-induced hypersensitivity reactions. Previously we have revealed that therapeutic plasma concentrations of DT can be achieved in normal and tumor-bearing dogs when DT is administered PO in combination with oral cyclosporin A (CSA). The purpose of this study was to identify the maximally tolerated dosage and characterize the pharmacokinetic disposition of oral DT combined with CSA in cats with tumors. Eighteen tumor-bearing cats were enrolled in this phase I dose escalation and pharmacokinetic study. DT was administered by gavage with CSA (5 mg/kg) twice over a 3-week period. The starting dose of DT was 1.0 mg/kg. Based on the clinical toxicity profile, with gastrointestinal adverse effects and hematologic toxicity the maximal tolerated dose of oral DT was 1.75 mg/kg in combination with 5 mg/kg CSA. Additional studies are necessary to determine the efficacy of DT/CSA in cats with epithelial tumors.
Effects of Growth Hormone Therapy in Children with Idiopathic Short Stature (2005)

이 논문은 2004년도 충북대학교 학술연구지원사업의 연구비 지원에 의 하여 연구되었음. 접수 : 2005년 3월 22일, 승인 : 2005년 5월 10일 책임저자 :한헌석, 충북대학교 의과대학 소아과학교실 Correspondence : Heon Seok Han, M.D. Tel : 043)269-6370 Fax : 043)264-6620 E-mail : hshan@chungbuk.ac.kr 간의 성장은 적절한 성장호르몬의 생성과 표적 기관의 적절한 반응을 필요로 한다. 성장호르몬의 결핍과 과다는 극단적으로 작거나 큰 키를 만들 수 있으며, 좀 덜 극단적인 경우의 작은 키나 큰 키에서도 성장 호르몬이 성장 조절에 중추적인 역할을 할 것이라고 가정할 수 있다. 또한 성장의 변이는 다양한 성장호르몬의 분비와 민감도의 복합 작용으로 이루어진다고 할 수 있다. 저신장을 가진 많은 소아들이 혈중 성장호르몬 농도가 성장호르몬 결핍증을 진단하 는 기준치 이상을 보이는데도 불구하고 성장 호르몬 결핍으로 진단되는 소아와 같은 정도의 저신장을 보이는 경우가 있다 1) . 이러한 특발성 저신장증(idiopathic short stature)은 불충분한 성장호르몬의 분비, 성장호르몬에 대한 감수성의 감소, 혹은 이 특발성 저신장증 소아에서 성장호르몬의 치료효과
Cardiac output during human sleep. (1976)

The attenuated nitric oxide (NO) formation and/or elevated production of reactive oxygen species are often found in experimental and human hypertension. We aimed to determine possible effects of N-acetylcysteine (1.5 g/kg/day) and N-acetyl-5-methoxytryptamine (melatonin, 10 mg/kg/day) in adult spontaneously hypertensive rats (SHR) with established hypertension. After a six-week-treatment, blood pressure was measured and NO synthase (NOS) activity, concentration of conjugated dienes, protein expression of endothelial NOS, inducible NOS and nuclear factor-kappaB (NF-kappaB) in the left ventricle were determined. Both treatments improved the NO pathway by means of enhanced NOS activity and reduced reactive oxygen species level as indicated by decreased conjugated diene concentrations and lowered NF-kappaB expression. N-acetylcysteine (but not melatonin) also increased the endothelial NOS protein expression. However, only melatonin was able to reduce blood pressure significantly. Subsequent in vitro study revealed that both N-acetylcysteine and melatonin lowered the tone of phenylephrine-precontracted femoral artery via NO-dependent relaxation. Nevertheless, melatonin-induced relaxation also involved NO-independent component which was preserved even after the blockade of soluble guanylate cyclase by oxadiazolo[4,3-a]quinoxalin-1-one. In conclusion, both N-acetylcysteine and melatonin were able to improve the NO/reactive oxygen species balance in adult SHR, but blood pressure was significantly lowered by melatonin only. This implies that a partial restoration of NO/reactive oxygen species balance achieved by the antioxidants such as N-acetylcysteine has no therapeutic effect in adult rats with established hypertension. The observed antihypertensive effect of melatonin is thus mediated by additional mechanisms independent of NO pathway.
Anatomical and physiological properties of feedback neurons of the mushroom bodies in the bee brain. (1987)

"Feedback neurons" in the bee's mushroom body were recorded from and filled iontophoretically with either Lucifer Yellow or cobalt-hexammino-chloride (III). The neurons have complex shapes arborizing in one, or sometimes two layers of the alpha-lobe, and sometimes in the beta-lobe and pedunculus. Their axons project via the protocerebral-calycal-tract into the calyx lip and collar zones, ending as blebbed processes. Additionally these neurons also project around the alpha-lobe into the protocerebrum. More than 70% of the recorded neurons were multimodal responding to several test-stimuli. These include: light, airstreams towards the antennae and the abdomen, various odors, water and sugar-water presented to the antennae and proboscis, and mechanical stimulation of the legs. Responses were usually excitatory and in many cases showed aftereffects which lasted for many seconds. Some neurons showed spontaneous changes in their response-properties. There appeared to be no clear match between the modality of any one neuron and the anatomical features of its dendritic regions. The possible functional rôles of feedback neurons in learning and behaviour are discussed with particular reference to their structural identity as a recurrent loop from the lobes to the calyces.
Railway Network Timetabling and Dynamic Traffic Management (2010)

The paper discusses the current state of research concerning railway network timetabling and traffic management. Timetable effectiveness is governed by frequency, regularity, accurate running, recovery and layover times, as well as minimal headway, buffer times and waiting times. Analytic (queuing) models and stochastic micro-simulation are predominantly used for estimation of waiting times and capacity consumption anlong corridors and in stations, while combinatorial models and stability analysis are suitable for network timetable optimisation. Efficient traffic management can be achieved by real-time monitoring, fusion, analysis and rescheduling of railway traffic in case of disturbances. Real-time simulation, optimisation and impact evaluation of dispatching measures can improve the effectiveness of rescheduling and traffic management. The display of dynamic signal and track occupancy data in driver cabins, as RouteLint developed by ProRail, can support anticipative actions of the driver in order to reduce knock-on delays and increase throughput.
Using cluster ensemble and validation to identify subtypes of pervasive developmental disorders. (2007)

Pervasive Developmental Disorders (PDD) are neurodevelopmental disorders characterized by impairments in social interaction, communication and behavior. Given the diversity and varying severity of PDD, diagnostic tools attempt to identify homogeneous subtypes within PDD. Identifying subtypes can lead to targeted etiology studies and to effective type-specific intervention. Cluster analysis can suggest coherent subsets in data; however, different methods and assumptions lead to different results. Several previous studies applied clustering to PDD data, varying in number and characteristics of the produced subtypes. Most studies used a relatively small dataset (fewer than 150 subjects), and all applied only a single clustering method. Here we study a relatively large dataset (358 PDD patients), using an ensemble of three clustering methods. The results are evaluated using several validation methods, and consolidated through an integration step. Four clusters are identified, analyzed and compared to subtypes previously defined by the widely used diagnostic tool DSM-IV.
Biologic therapy for colon cancer. (2005)

Targeted biologic therapy remains a very active and evolving field since the US Food and Drug Administration approved cetuximab, a recombinant, human/mouse chimeric monoclonal antibody against the endothelial growth factor receptor, and bevacizumab, a humanized monoclonal antibody directed against vascular endothelial growth factor, for the treatment of colorectal cancer. Benefits of these reagents in diverse clinic settings combined with different chemotherapeutic agents are being defined. Current research is focused on defining which patients will benefit from these treatments and how best to use them in the clinic. Additional preclinical and clinical studies will enable better usage of these biologic agents and lead to the development of new targeted therapies for the treatment of colon cancer.
Scrub Typhus Reemergence in the Maldives (2003)

In summer 2002, an outbreak of febrile illness began in the Maldives in the Indian Ocean. Through April 2003, officials recorded 168 cases with 10 deaths. The Armed Forces Research Institute of Medical Sciences in Bangkok confirmed Orientia tsutsugamushi and conducted a joint investigation with the Ministry of Health, Maldives. These cases of scrub typhus were the first in the Maldives since World War II.
The Equilibrium Between Carbon Monoxide, Carbon Dioxide, Sulfur Dioxide, and Free Sulfur (1917)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Regulation of Caspase Activation and <i>cis</i>-Diamminedichloroplatinum(II)-Induced Cell Death by Protein Kinase C (1999)

Activation of caspases is critical for the induction of apoptosis. We have shown previously that cell death mediated by the anticancer agent cis-diamminedichloroplatinum(II) (cDDP) is influenced by the protein kinase C (PKC) signal transduction pathway. In the present study, we have examined whether regulation of cDDP sensitivity by PKC involves caspase activation. cDDP caused a time- and concentration-dependent increase in the generation of the catalytic fragment (CF) of novel (n) PKCdelta, nPKCepsilon, and atypical (a) PKCzeta but had little effect on conventional (c) PKCalpha. Cleavage of PKC isozymes was associated with the activation of caspase-3 and -7 but not of caspase-2. PKC activators enhanced cDDP-induced cleavage of these isozymes and activation of caspase-3. Rottlerin, an inhibitor of nPKCdelta, blocked caspase-3 activation and proteolytic cleavage of nPKCdelta by cDDP. Bryostatin 1, which elicits a biphasic concentration-response in potentiating cell death by cDDP, exhibited a similar biphasic effect on cDDP-induced activation of caspase-3 and caspase-7 and the cleavage of poly(ADP-ribose) polymerase; while 1 nM bryostatin 1 induced maximum activation of these caspases, 1 microM bryostatin 1 had little effect. z-DEVD-fmk, an inhibitor of caspase-3-like proteases, prevented cDDP-induced cell death. Bryostatin 1 also induced a similar biphasic down-regulation of nPKCdelta but not of cPKCalpha or nPKCepsilon. These results suggest that nPKCdelta not only acts downstream of caspases but also regulates the activation of caspases and that the biphasic concentration response of bryostatin 1 on cDDP-induced cell death could be explained by its distinct effect on nPKCdelta down-regulation and caspase activation.
Hereditary orotic aciduria. II. A urinary screening test. (1968)

A urinary screening test for hereditary orotic aciduria is described. The test is based upon the conversion of orotic acid to barbituric acid by the action of saturated bromine water and subsequent reduction by ascorbic acid. Barbituric acid reacts with p-dimethylaminobenzaldehyde (Ehrlich9s Reagent) to form a colored product with a maximal absorption at wave-length 480 mµ. The screening test may be used to detect subjects either homozygous or heterozygous for hereditary orotic aciduria. Quantitation of urinary orotic acid is possible only when the concentration is high, as is found in the urine of the homozygote. The test requires a small aliquot of a random urine specimen, it is easy to perform, and many samples may be determined simultaneously.
Use of Crack Branching Data for Measuring Near‐Surface Residual Stresses in Tempered Glass (1989)

An analytical procedure based on fracture mechanics is used to obtain the amount of residual stress in glass from measurements on the fracture surface. The technique utilizes the measurement of microcrack branching distances, known as the mirror — mist boundary, which occur at a critical crack branching stress intensity (K m ) value. This procedurre shows that σ A r m 1/2 Y F (θ) =σ R r 1/2 m +Ψ 0 , where σ A is the applied stress, r m is the microcrack branching radius, σ R is the residual stress, Y F ( θ ) is the crack‐border correction factor, and Ψ 0 is a material constant based on K m . Thus, the equation is that of a straight line with the slope equal to the magnitude of the residual stress. Data for tempered glass from the literature are used to demonstrate the applicability of the technique.
Modification of a Thermogravimetric Balance for Pyrolysis Experiments in a Controlled Atmosphere. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModification of a Thermogravimetric Balance for Pyrolysis Experiments in a Controlled Atmosphere.D. A. SmithCite this: Anal. Chem. 1963, 35, 9, 1306–1307Publication Date (Print):August 1, 1963Publication History Published online1 May 2002Published inissue 1 August 1963https://pubs.acs.org/doi/10.1021/ac60202a026https://doi.org/10.1021/ac60202a026research-articleACS PublicationsRequest reuse permissionsArticle Views27Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CMOS T/R Switch Design: Towards Ultra-Wideband and Higher Frequency (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents the comprehensive considerations of CMOS transmit/receive (T/R) switch design towards ultra-wideband and over 15-GHz frequencies. Techniques for minimizing parasitics and increasing linearity are discussed. A customized transistor layout is proposed for T/R switch design and its effects on insertion loss and isolation are studied. The analysis shows that a series-only architecture using the customized transistor layout achieves better insertion loss and reasonable isolation. A double-well body-floating technique is proposed and its effects are discussed. A differential switch architecture without shunt arms is designed and verified by experimental results. Fabricated in 0.13-<formula formulatype="inline"><tex>$\mu{\hbox {m}}$</tex></formula> triple-well CMOS, the T/R switch exhibits less than 2 dB insertion loss and higher than 21 dB isolation up to 20 GHz. With resistive body floating and differential architecture, the high linearity is of ultra-wideband characteristic, more than 30-dBm power 1-dB compression point <formula formulatype="inline"> <tex>$({\rm P}_{1{\rm dB}})$</tex></formula> is obtained up to 20 GHz in only 0.03 <formula formulatype="inline"><tex>${\hbox {mm}}^{2}$</tex></formula> active die area. </para>
Multimodal biometric authentication based on score level fusion using support vector machine (2008)

Abstract Fusion of multiple biometrics for human authentication performance improvement has received considerable attention. This paper presents a novel multimodal biometric authentication method integrating face and iris based on score level fusion. For score level fusion, support vector machine (SVM) based fusion rule is applied to combine two matching scores, respectively from Laplacianface based face verifier and phase information based iris verifier, to generate a single scalar score which is used to make the final decision. Experimental results show that the performance of the proposed method can bring obvious improvement comparing to the unimodal biometric identification methods and the previous fused face-iris methods.
Weighted control research on seamless transfer for dual-mode three phase inverter in micro-grid (2011)

The utility-interactive inverters can operate in grid-connected and islanded mode. The key technology of dual-mode inverter is to achieve the seamless transfer and reduce the impact of current and voltage to load or grid. A practical grid-connected switch is a physical switch and the switching delay exists. The paper analyzes the influence of the switching delay in detail, that is, there is a uncontrollable intermediate state in the transfer process of grid-connected or off-grid, which will cause voltage and current overshoot. This paper presents a voltage and current weighted control strategies without increasing system complexity. The strategy can ensure that the transient transfer is seamless transfer. Simulations based on MATLAB are carried out and the experiments based on a three-phase inverter verify this method feasibility.
Where is nursing heading? (2006)

Our Health, Our Care, Our Say (Department of Health (DH), 2006a) set the scene for continuing change within the NHS and the most recent follow-up document (DH, 2006b) confirms the direction of travel. It is contended that current services are falling short by causing frustrating delays and disjointed care journeys to patients.
New aspects of digital color image enhancement (1999)

The spatial and chromatic dimensions of digital color image information exhibit unique interrelationships that invite new, color-image-specific, processing strategies. A quantitative exploration of these interrelationships is performed. The resulting data reveals key traits that lead to two new methods of color image enhancement. The first is a method of color image contrast enhancement that exploits the existence of high-pass spatial energy in certain chromatic color components. We present a new, spatially adaptive approach that acknowledges the spatially varying nature of cross-component correspondences. This new approach is suitable for use in any color space. The second is a method of color image denoising that exploits the unique correspondences of polychromatic multiscale edges at fine scales of analysis. The multiscale edges are derived using wavelet methods. This approach preserves image details and noticeably outperforms wavelet thresholding methods of denoising in images containing natural foliage.
An Empirical Study on Leveraging Logs for Debugging Production Failures (2019)

In modern software development, maintenance is one of the most expensive processes. When end-users encounter software defects, they report the bug to developers by specifying the expected behavior and error messages (e.g., log message). Then, they wait for a bug fix from the developers. However, on the developers' side, it can be very challenging and expensive to debug the problem. To fix the bugs, developers often have to play the role of detectives: seeking clues in the user-reported logs files or stack trace in a snapshot of specific system execution. This debugging process may take several hours or even days. In this paper, we first look at the usefulness of the user-reported logs. Then, we propose an automated approach to assist the debugging process by reconstructing the execution path. Through the analysis, our investigation shows that 31% of the time, developer further requests logs from the reporter. Moreover, our preliminary results show that the reconducted path illustrates the user's execution. We believe that our approach proposes a novel solution in debugging production failures.
Bone Marrow Transplants (1990)

In Reply.— The first issue is whether or not bone marrow transplantation is, indeed, the most effective therapy available for children with leukemia. Drs Ogden and Steuber refer to "more than a decade of literature in which good responses after bone marrow transplantation have been reported." Likewise, Drs Weinblatt et al state that "the majority of patients currently receiving transplantation therapy for. . .leukemia in first remission are cured. . . ." However, Pinkel (Leukemia. 1989;3:242-244), in a recent editorial, carefully and succinctly reviewed the relevant data and concluded the exact opposite.
p53 gene mutation: software and database (1996)

A large number of different mutations in the p53 tumor suppressor gene have been identified in all types of cancer. As of October, 1997, this database (http:// perso.curie.fr/tsoussi ) contained >7500 mutations. Such a substantial increase since our previous reports should enable epidemiological analyses which were not previously possible. In order to analyse these new data, the UMD software has been improved. A new Web version of the UMD software enables online analysis of the database. The present report describes various improvements since the last release of the database.
The run of a golf ball (2002)

The run, which includes both the bounce and the roll, of a golf ball landing on turf is modeled. The effect of launch speed, impact angle, backspin, and green firmness on the run for a variety of golf shots is considered. It is found that the dominant factor that determines the length of the run, in the case of drives, is the impact angle. It is also found that for high-lofted iron shots, where the golf ball is given sufficient backspin, the ball may, for firm enough greens, initially bounce forward before running backwards. PACS No.: 01.80+b
Chemical reactivation of exterior decorative aerospace topcoats (2013)

Exterior aerospace topcoats are typically highly cross-linked polyurethane based paints designed to be resistant to UV degradation with a high level of adhesion required during all aspects of flight. These topcoats are also designed to be resistant and inert to a variety of aggressive solvents and airplane fluids. Consequently, during processing, a topcoat surface can be inert to the reception of the next topcoat layer. Proper surface preparation of each paint layer prior to the application of the next is critical for ensuring adequate adhesion. Historically, the only viable method to prevent de-bonding of cured paints has been to mechanically abrade (sand) prior to the application of subsequent coating layers. However, sanding is an economically hazardous process, adds process flow time, and produces contamination. In addition, sanding intricate stencil lettering in most cases is not feasible without tearing the stencil material and/or leaving visible scratches in the areas immediately surrounding the stencil markings. Chemical reactivation using a newly developed alkoxide-based chemical reactivator has proven to be a viable alternative to scuff sanding and has been successfully implemented on multiple aerospace platforms. This paper discusses the properties and application process of aerospace decorative livery, the mechanism and tests available for rain erosion durability and the performance of paint layers bonded by the chemical reactivation process.