gebhart/patrepeval huggingface dataset:
[Alzheimer's disease. Presentation of 7 cases in 3 families]. (1987)

L'objet de ce travail est de presenter 3 familles dans lesquelles la maladie d'Alzheimer parait suivre un mode hereditaire autosomique dominant, d'analyser quelques caracteristiques cliniques importantes chez ces malades comme l'âge de debut precoce et de faire une revision de la litterature relative a l'importance des facteurs genetiques dans la maladie
Methods for the Detection of Peptidylarginine Deiminase (PAD) Activity and Protein Citrullination (2013)

The post-translational conversion of peptidylarginine to peptidylcitrulline, a process also known as citrullination, is catalyzed by the enzyme family of peptidylarginine deiminases (PADs) and has been demonstrated to be involved in many physiological processes, including the regulation of gene expression. In addition, citrullination has been shown to be associated with several diseases, such as cancer, multiple sclerosis, rheumatoid arthritis, and Alzheimer's disease. To get more insight into the role of PAD enzymes and citrullination in both health and disease, experimental strategies to study PAD activity and to characterize citrullinated proteins in complex biological samples are crucial. Here, we describe the chemical, proteomic and antibody-based procedures that are currently available and discuss their applicability for the analysis of complex samples. The methods that have been developed can be used to provide more insight in the substrate specificity of PAD enzymes. Because the evidence that PADs play a pathophysiological role in the diseases mentioned above is increasing, they become attractive targets for therapeutic interventions. More knowledge of PAD specificity and the availability of reliable, high-throughput assays for PAD activity will facilitate the development of highly specific PAD inhibitors.
Three Years of Controlled Traffic Cropping at Roseworthy (1992)

Field trials were established in 1989 on a red-brown earth using a prototype gantry to demonstrate controlled traffic methods and to measure crop and soil responses to deep tillage and wheel traffic. The four treatments imposed were conventional traffic (C), conventional traffic following deep ripping (CR), controlled traffic (CT) and controlled traffic following deep ripping (CTR). Grain yields of faba beans (viscea faba) and wheat (triticum aestivum) showed yield advantages of 11-17% in favour of CT in 1990, 91. An increase in the grain-to-biomass ratio was also recorded in the CT and CTR treatments. Cone penetrometer resistances were lowest in CTR treatment but root densities at the 300 mm depth were highest in CT treatment. It is concluded that controlled traffic methods are likely to make an important contribution toward a sustainable system and it is suggested that the geometry of a gantry is better suited to broadacre agriculture than a tractor and trailed implements.
ENHANCEMENT OF OPTICAL SECOND-HARMONIC GENERATION (SHG) BY REFLECTION PHASE MATCHING IN ZnS AND GaAs (1966)

First Page
Imaging and Radioanalytical Techniques in Interdisciplinary Research - Fundamentals and Cutting Edge Applications (2013)

The overall goal of this book is to promote research and development of imaging and radioanalytical techniques by publishing high-quality chapters in this rapidly growing interdisciplinary field. This book discusses the principles and applications of imaging and radioanalytical techniques across a wide spectrum of interdisciplinary science, technology and medicine, where these techniques are expected to make significant difference and contribution. It also explores the history of the field, current trends, and future directions. The book focuses mainly on cutting-edge applications, and associated equipments and methods, such as instrumentation systems and computing hardware/software. The primary target audience for this book includes students, researchers, clinicians, and professionals who are interested in medical and ground penetrating radar (GPR) imaging, and radioanalytical techniques.
Rational Design of Novel Glycomimetic Peptides for E-Selectin Targeting (2021)

E-selectin is a cell-adhesion receptor with specific recognition capacity toward sialo-fucosylated Lewis carbohydrates present in leukocytes and tumor cells. E-selectin interactions mediate the progress of inflammatory processes and tumor metastasis, which aroused the interest in using this protein as a biomolecular target to design glycomimetic inhibitors for active targeting or therapeutic purposes. In this work, we report the rational discovery of two novel glycomimetic peptides targeting E-selectin based on mutations of the reference selectin-binding peptide IELLQAR. Sixteen single or double mutants at Ile1, Leu3, Leu4, and Arg7 residues were evaluated as potential candidates for E-selectin targeting using 50 ns molecular dynamics (MD) simulations. Nine peptides showing a stable association with the functional pocket were modified by adding a cysteine residue to the N-terminus to confer versatility for further chemical conjugation. Subsequent 50 ns MD simulations resulted in five cysteine-modified peptides with retained or improved E-selectin binding potential. Then, 300 ns accelerated MD (aMD) simulations were used to examine the binding properties of the best five cysteine-modified peptides. CIEELQAR and CIELFQAR exhibit the most selective association with the functional pocket of E-selectin, as revealed by potential of mean force profiles. Microscale thermophoresis experiments confirmed the E-selectin binding capacity of the selected peptides with <i>K</i><sub>D</sub> values in the low micromolar range (CIEELQAR <i>K</i><sub>D</sub> = 35.0 ± 1.4 μM; CIELFQAR <i>K</i><sub>D</sub> = 16.4 ± 0.7 μM), which are 25-fold lower than the reported value for the native ligand sLe<sup>x</sup> (<i>K</i><sub>D</sub> = 878 μM). Our findings support the potential of CIEELQAR and CIELFQAR as novel E-selectin-targeting peptides with high recognition capacity and versatility for chemical conjugation, which are critical for enabling future applications in active targeting.
Churg-Strauss syndrome (Allergic Angiitis and Granulomatosis) (2010)

A 25-year-old woman suffered from sinusitis, asthma and chronic cough intermittently for 1 year was admitted due to persistent worsening cough for 2-3 weeks. Her examination revealed a weakness in appearance and initial blood test results showed marked eosinophilia: WBC of 14100/cumm, neutrophil at 49%, lymphocyte at 13%, and eosinophil at 32%. Chest x–ray showed bilateral pulmonary nodules (Fig. 1) and computed tomography (CT) scan also demonstrated multiple peripheral pulmonary nodules, which suggested chronic eosinophil pneumonia (Fig. 2). However during hospitalization, her sputum TB, fungus, and bacteria cultures all showed no growth. In addition, sputum cytology, serum anti-nuclear antibody, antineutrophil cytoplasmic autoantibody and serum rheumatoid factor results were all negative. Bone marrow biopsy demonstrated eosinophilia and serum total eosinophil count increased up to 13030 /cumm. After treatment with prednisolone, she was discharged under the diagnosis of Churg-Strauss syndrome in a stable condition and her follow-up CT scan showed almost complete remission.
A Study on Goddesses Hair Arts Shown in History of Arts (2007)

Arts is the expression of reasoning and conscious life of human and arouse human the concept of existence, utmost emotion and excellent thoughts. Also it makes humans life very abundant. I make it come first to get rid of the art thirst on the opposite sight of technical one for hair as on part of humans body. Next purpose is that to confirm the esthetic value of 'hair arts' by solidify the academic ground of beauty arts through creating 'hair arts' works and learning and make the direction for the beauty industry and education of the next generation. In this study I investigated the Greek myth and the hair styles of ancient Greek Goddesses. On the basis of that symbols I elaborated hair formative works made of metal and studied, analyzed and displayed that. Work No.1 'aphne' pictures the second of changing into a laurel tree avoiding the love. Secondly 'Muse Erato' was exhibited the peaceful figure that have enough the fine melodies. 'Leda' brings out the feature of Leda resembling a swan and the fourth piece, 'Eos' conveys the brilliant and mystery of dawn. So this study conducted based on the concept of practical hair and have made efforts to be close to theoretical manufacturing research needed at making hair arts works and academic one needed at organic design composition for pioneering new field, 'art hair.' I hope these 'hair arts' works make creativity of the practise hair alive. It will be very thankful to me if this study can help even though slightly for splendid beauty arts to make its status firm as a one part of arts, and there are following studies.
CaF<sub>2</sub>/CdF<sub>2</sub> Double-Barrier Resonant Tunneling Diode with High Room-Temperature Peak-to-Valley Ratio (2000)

We have demonstrated room-temperature negative differential resistance (NDR) with a high peak-to-valley ratio (PVR) on the order of 10 5 using CaF 2 /CdF 2 double-barrier resonant tunneling diode (DBRTD) structures grown on Si(111) substrates. A CdF 2 quantum-well layer was grown by molecular-beam epitaxy (MBE) and CaF 2 barrier layers were formed by MBE combined with the partially ionized beam technique on an n + -Si(111) substrate with 0.07° miscut, in order to reduce the pinhole density of CaF 2 barrier layers. The dispersion of the peak current density and bias voltage of the NDR implies that the layer thickness fluctuation of each CaF 2 barrier and CdF 2 quantum-well layer is suppressed below ±1 unit layer of the (111) atomic plane for DBRTDs with an 18 µm diameter electrode. The peak and valley currents agreed reasonably with those obtained by theoretical estimation.
Atypical hemolytic uremic syndrome and mutation analysis of factor H gene in two Tunisian families (2010)

We carried out a protein and genetic investigation of the factor H gene mutations within two families presenting with a diagnostic suspicion of atypical hemolytic uremic syndrome (aHUS). The results within the patients of the first family revealed a factor H-deficiency. Direct sequencing allowed the detection of a 4-nucleotide deletion in the factor H gene. This deletion was found as the homozygote form in the proband and as the heterozygote form in the parents. Protein and functional analyses of the complement system were normal in all members of the second family. However, the molecular investigation for the father showed the presence of an amino acid substitution in the FH gene. Unfortunately, his two affected children died without being investigated for mutations. The functional consequences of these abnormal proteins are still to be demonstrated.
Evaluation of combined high-efficiency DNA extraction and real-time PCR for detection of Mycobacterium avium subsp. paratuberculosis in subclinically infected dairy cattle: comparison with faecal culture, milk real-time PCR and milk ELISA (2012)

This study highlights the advantages of HYDEqPCR for detection of Map in subclinically infected populations, in comparison with faecal culture, milk qPCR and milk ELISA. HYDEqPCR can detect low-level Map shedders that go undetected using these other methods, which will thus underestimate the proportions of Map-shedders in herds. Identification of these shedding animals is extremely important for prevention of the spread of Map infection in an animal population. Due to the relatively high sensitivity and specificity of HYDEqPCR, it can be applied to test for Map at the herd or individual level, regardless of animal age or production stage. HYDEqPCR will allow early detection and control of Map in any population at risk.
[Designing and manufacturing of medical equipment by OAO MNPK "Avionika"]. (2004)

The paper is dedicated to the activity of Research and Production Enterprise "Avionika", a leader in the field of designing and manufacturing of medical equipment. Technical data of medical suction units produced by the enterprise were comparatively analyzed versus those made by other manufacturers. Additionally, failures of suction equipment were analyzed and technical solutions enhancing the operational safety are suggested. Promising trends are defined for perfecting the discussed equipment type.
Automatic detection of player positions and trajectories during a soccer match for the measurement of physical and tactical performance (2007)

This paper describes a video-data processing solution for determining the positions of all players during the course of a team sporting event. Signals received from three fixed cameras that cover the entire playing area are treated by modelling of the background and extraction of the positions of the players in motion. The gathered data makes it possible to measure the physical performance of each player (expended effort and its distribution per period of play) as well as the tactical performance based on the polygons formed by players of the same team or the same section. The laws of perspective projection are exploited to represent the positions of the players on the field.
Learning new words from spontaneous speech (1993)

The authors describe the design of a system to learn new words from spontaneous speech input, and present an initial experiment on detecting the new words to be learned. Learning a new word involves detecting an out-of-vocabulary word in the input, determining its meaning, and adding the word to the system lexicon and grammars. Such learning would enable later recognition, parsing, and interpretation of the new words.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Phase II randomized study of dacarbazine, carmustine, cisplatin and tamoxifen versus dacarbazine alone in advanced melanoma patients (2001)

This randomized phase II trial was performed to define the activity and toxicity of the combination of dacarbazine (DTIC), carmustine (BCNU), cisplatin (DDP) and tamoxifen (DBDT regimen) versus DTIC alone in patients with metastatic melanoma. Sixty patients with metastatic melanoma were randomly assigned to receive BCNU 150 mg/m2 intravenously (i.v.) on day 1, cisplatin 25 mg/m2 i.v. daily on days 1 to 3, DTIC 220 mg/m2 i.v. daily on days 1 to 3 and tamoxifen 160 mg orally daily for 7 days prior to chemotherapy (DBDT arm; arm A). Treatment cycles were repeated every 28 days, while BCNU was given every two cycles. The DTIC arm (arm B) patients received DTIC alone 1200 mg/m2 i.v. on day 1, repeated every 21 days. Patients were evaluated every two cycles; responding patients continued the treatment for a maximum of 12 cycles. The overall response rate was 26% in the DBDT arm and 5% in the DTIC arm. Complete responses were 2.5% for DBDT and 0% for DTIC. The median progression-free survival and the median survival were 4 and 9 months, respectively for DBDT, and 2 and 7 months for DTIC. DBDT was associated with significant haematological toxicity: 33% of the patients experienced a grade III or IV neutropenia and 28% a grade III or IV thrombocytopenia. In conclusion, the overall response rate obtained with DBDT was greater than that obtained with DTIC alone; however, this combination increases toxicity with limited impact on overall survival.
The Structure, Expression, and Function Prediction of <i>DAZAP2</i>, A Down-Regulated Gene in Multiple Myeloma (2004)

In our previous studies, DAZAP2 gene expression was down-regulated in untreated patients of multiple myeloma (MM). For better studying the structure and function of DAZAP2, a full-length cDNA was isolated from mononuclear cells of a normal human bone marrow, sequenced and deposited to Genbank (AY430097). This sequence has an identical ORF (open reading frame) as the NM_014764 from human testis and the D31767 from human cell line KG-1. Phylogenetic analysis and structure prediction reveal that DAZAP2 homologues are highly conserved throughout evolution and share a polyproline region and several potential SH2/SH3 binding sites. DAZAP2 occurs as a single-copy gene with a four-exon organization. We further noticed that the functional DAZAP2 gene is located on Chromosome 12 and its pseudogene gene is on Chromosome 2 with electronic location of human chromosome in Genbank, though no genetic abnormalities of MM have been reported on Chromosome 12. The ORF of human DAZAP2 encodes a 17-kDa protein, which is highly similar to mouse Prtb. The DAZAP2 protein is mainly localized in cytoplasm with a discrete pattern of punctuated distribution. DAZAP2 may associate with carcinogenesis of MM and participate in yet-to-be identified signaling pathways to regulate proliferation and differentiation of plasma cells.
<b>Volume Changes in Protein Reactions. I. Ionization Reactions of Proteins</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVolume Changes in Protein Reactions. I. Ionization Reactions of ProteinsJoachim. Rasper and Walter. KauzmannCite this: J. Am. Chem. Soc. 1962, 84, 10, 1771–1777Publication Date (Print):May 1, 1962Publication History Published online1 May 2002Published inissue 1 May 1962https://pubs.acs.org/doi/10.1021/ja00869a001https://doi.org/10.1021/ja00869a001research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fiber bragg grating sensor for hydrogen detection in power transformers (2014)

A novel hydrogen sensor is designed on the basis of Fiber Bragg grating (FBG) sensing technique. The sensor can be arranged inside the transformer. It has several advantages, such as fast fault detection and location, immunity to electromagnetic interference, quasi-distribution measurement and real-time monitoring. The principle of the proposed FBG hydrogen sensor is based on changes of the physical properties of palladium films which absorb hydrogen. A thick palladium layer prepared by magnetron sputtering is used to achieve high sensitivity. Meanwhile, polyimide is added into the adhesive layer to improve the reliability of the sensor. Partial discharge experiments demonstrated that the wavelength shift of the FBG hydrogen sensor varies linearly with the concentration of hydrogen dissolved in the transformer oil. It is hardly disturbed by other factors. The hydrogen sensing experiment in oil at a temperature of 80°C revealed that the sensitivity of the sensor remains same as the temperature varies, ranging from room temperature to operating temperature of the power transformer. Thus, the proposed sensor can work properly under the operating temperature of power transformers.
Applied colloid chemistry,; (1921)

Book digitized by Google from the library of Harvard University and uploaded to the Internet Archive by user tpb.
Some new lens-prism correctors for prime focus (1990)

Neufs conceptions de correcteurs prisme-lentille et leurs performances sont presentees. Ces correcteurs sont concus pour le foyer principal d'un miroir primaire parabolique f/2 et de 7.5 m d'ouverture.
Performance of a Cross-Flow Fan with Various Stabilizer Positions and Rearguider Shapes (2004)

The design point of the cross-flow fan is generally based on the region within low static pressure and high flow rate. It relatively makes high dynamic pressure at low speed because a working fluid passes through an impeller blade twice. However, it has low static pressure efficiency between 30 % and 40 % because of relative high impact loss. The purpose of this study is to research the reciprocal relation among each parameter. Experiments and numerical analyses are conducted on effects of a stabilizer and a rearguider on performance analysis of a cross-flow fan. Two-dimensional, unsteady governing equations are solved using FVM, PISO algorithm, sliding grid system and standard k-ε turbulence model. Experiments are also carried out to estimate the performance of the modeled cross-flow fan. It is clarified that the rearguider of Archimedes type has excellent results for the most part.
Aerobic regulation of isocitrate dehydrogenase gene (icd) expression in Escherichia coli by the arcA and fnr gene products (1997)

Isocitrate dehydrogenase, the icd gene product, has been studied extensively regarding the regulation of enzymatic activity and its relationship to the metabolic flux between the tricarboxylic acid cycle and the glyoxylate bypass. In this study, the transcriptional regulation of icd gene expression was monitored by using an icd-lacZ gene fusion and shown to vary over a 15-fold range in response to changes in oxygen and carbon availability. Anaerobic cell growth resulted in fivefold-lower icd-lacZ expression than during aerobic growth. This negative control is mediated by the arcA and fnr gene products. When different carbon compounds were used for cell growth, icd-lacZ expression varied threefold. The results of continuous cell culture studies indicated that this control may be due to variations in cell growth rate rather than to catabolite repression. DNase I footprinting at the icd promoter revealed a 42-bp ArcA-phosphate-protected region that overlaps the start site of icd transcription. Phosphorylation of ArcA considerably enhanced its binding to DNA, while ArcA-phosphate exhibited an apparent dissociation value of approximately 0.1 microM. Based on these studies, ArcA appears to function as a classical repressor of transcription by binding at a site overlapping the icd promoter during anaerobic cell growth conditions.