gebhart/patrepeval huggingface dataset:
Immunogenicity of Moraxella bovis hemolysin. (1985)

Anti-Moraxella bovis hemolysin activity was observed in 35 cattle exposed to field infections of infectious bovine keratoconjunctivitis (IBK). All cattle in infected herds seroconverted with respect to antihemolysin whether or not clinical IBK was noted. Cattle previously exposed to IBK possessed higher antihemolysin titers than did younger, nonexposed cattle. Antihemolysin activity was noted in bovine sera up to 7 years after exposure to IBK. Sera from experimentally infected calves were found to possess antihemolytic activity against all 33 strains of M bovis tested. Antihemolytic activity could be demonstrated in random-bred mice inoculated with whole doxycycline-treated M bovis, frozen or lyophilized whole M bovis, and membrane fractions treated with sodium lauryl sarcosinate, Triton X 100, and Triton X 100 + EDTA, but not with formalin-treated whole M bovis.
Clomipramine augmentation in treatment-resistant depression (1997)

In depression that is resistant to tricyclic antidepressant (TCA) therapy, the substitution of a selective serotonin re-uptake inhibitor (SSRI), clomipramine, or a monoamine oxidase (MAO) inhibitor has been recommended. However, adding an additional antidepressant medication from a different drug class may produce even more rapid efficacy. In this regard, the combination of a MAO inhibitor or a SSRI plus a TCA has been shown to be of value in treatment-resistant depression (TRD). In this report, we examined the efficacy of clomipramine augmentation in 20 patients who failed to respond to either a MAO inhibitor or fluoxetine therapy for at least a 6-week period, and compared this to a third group given MAO inhibitor plus a conventional TCA. Two out of 9 (22%) MAO inhibitor/clomipramine patients and 4 out of 11 (36%) fluoxetine/clomipramine patients improved (Fisher's Exact test, P = ns), compared to 3 out of 7 (43%) patients taking MAO inhibitor/TCA (P = ns). However, the MAO inhibitor/clomipramine group experienced significantly more adverse events which necessitated stopping treatment (56%) when compared to the fluoxetine/clomipramine (9%) and compared to the MAO inhibitor/TCA group (0%) (chi 2 = 8.9, df = 2, P < 0.05). These adverse events included several cases of serotonin syndrome of mild to moderate severity. These observations indicate that clomipramine augmentation of a failed MAO inhibitor trial is of marginal efficacy (compared to augmentation with a conventional TCA) and should be employed with extreme caution.
Bone Marrow Mesenchymal Stem Cells and Electroacupuncture Downregulate the Inhibitor Molecules and Promote the Axonal Regeneration in the Transected Spinal Cord of Rats (2010)

Our previous study has reported that electroacupuncture (EA) promotes survival, differentiation of bone marrow mesenchymal stem cells (MSCs), and functional improvement in spinal cord-transected rats. In this study, we further investigated the structural bases of this functional improvement and the potential mechanisms of axonal regeneration in injured spinal cord after MSCs and EA treatment. Five experimental groups, 1) sham control (Sham-control); 2) operated control (Op-control); 3) electroacupuncture treatment (EA); 4) MSCs transplantation (MSCs), and 5) MSCs transplantation combined with electroacupuncture (MSCs + EA), were designed for this study. Western blots and immunohistochemical staining were used to assess the fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycans (CSPGs) proteins expression. Basso, Beattie, Bresnahan (BBB) locomotion test, cortical motor evoked potentials (MEPs), and anterograde and retrograde tracing were utilized to assess cortical-spinal neuronal projection regeneration and functional recovery. In the MSCs + EA group, increased labeling descending corticospinal tract (CST) projections into the lesion site showed significantly improved BBB scales and enhanced motor evoked potentials after 10 weeks of MSCs transplant and EA treatment. The structural and functional recovery after MSCs + EA treatment may be due to downregulated GFAP and CSPGs protein expression, which prevented axonal degeneration as well as improved axonal regeneration.
A Novel Risk Identification Framework for Cloud Computing Security (2015)

This paper introduces the Operationally Critical Threat, Asset, and Vulnerability Evaluation (OCTAVE) Allegro methodology as a novel framework to identify risks for Cloud Computing. According to Cloud Security Alliance (CSA), before applying security controls in Cloud Computing, risks and threats must be effectively identified and assessed. OCTAVE Allegro approach being introduced is designed to allow broad assessment of Cloud Computing operational risk environment with the goal of producing more robust results without the need for extensive risk assessment knowledge. This approach differs from others by focusing primarily on information assets in the context of how they are used, where they are stored, transported, and processed, and how they are exposed to threats, vulnerabilities, and disruptions as a result.
In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease (2017)

Adeno-associated virus (AAV) has shown promising therapeutic efficacy with a good safety profile in a wide range of animal models and human clinical trials. With the advent of clustered regulatory interspaced short palindromic repeat (CRISPR)-based genome-editing technologies, AAV provides one of the most suitable viral vectors to package, deliver, and express CRISPR components for targeted gene editing. Recent discoveries of smaller Cas9 orthologues have enabled the packaging of Cas9 nuclease and its chimeric guide RNA into a single AAV delivery vehicle for robust <i>in vivo</i> genome editing. Here, we discuss how the combined use of small Cas9 orthologues, tissue-specific minimal promoters, AAV serotypes, and different routes of administration has advanced the development of efficient and precise <i>in vivo</i> genome editing and comprehensively review the various AAV-CRISPR systems that have been effectively used in animals. We then discuss the clinical implications and potential strategies to overcome off-target effects, immunogenicity, and toxicity associated with CRISPR components and AAV delivery vehicles. Finally, we discuss ongoing non-viral-based <i>ex vivo</i> gene therapy clinical trials to underscore the current challenges and future prospects of CRISPR/Cas9 delivery for human therapeutics.
Optimal Wound Healing under Op-Site Dressing (1984)

Op-Site is a popular skin-graft donor-site dressing. The formation of hematomas or seromas with their troublesome consequences is effectively prevented by the incorporation of a closed drainage system.
Imaging of activated caspase-3 in living cell by fluorescence resonance energy transfer during photosensitization-induced apoptosis (2005)

Photodynamic therapy (PDT) is a novel and promising cancer treatment that employs a combination of a photosensitizing chemical and visible light, induces apoptosis in cell, and activation of caspase-3 is considered to be the final step in many apoptosis pathways. The changes of caspase-3 activation in cell during TNFα- and photodynamic therapy-induced apoptosis was measured by fluorescence resonance energy transfer (FRET) analysis. FRET probe consisting of fusions of an enhanced cyan fluorescent protein (ECFP), Venus and a linker peptide containing the caspase-3 cleavage sequence DEVD was utilized. Therefore, activated caspase-3 cleaved the linker peptide of FRET probe and disrupted the FRET signal. Human lung adenocarcinoma cell line (ASTC-a-1) were stably transfected with the plasmid (ECFP-DEVD-Venus) and then were treated by TNF-α and PDT, respectively. Experimental results indicated that caspase-3 activation resulted in cleavage of linker peptide and subsequent disruption of the FRET signal during TNFα- and photodynamic therapy-induced apoptosis, and that the activation of caspase-3 induced by photodynamic therapy was faster than that induce by TNF-α. The study supports that using FRET technique and different recombinant substrates as FRET probes could be used to detect the process of PDT-induced apoptosis and provide a new means to investigate apoptotic mechanism of PDT.
Bidirectional Forwarding Detection (BFD) for EVPN Ethernet Segment Failover Use Case (2019)

This document introduces a method for fast switchover of Designated
Forwarder for Ethernet Segment failover by using Bidirectional
Forwarding Detection protocol.
Sterling software (1995)

For a little over two years, Sterling Software ITD has been developing the Automatic Templating System (ATS) [1] for automatically extracting entity and event data in the counter-narcotics domain from military messages. This system, part of the Counter Drug Intelligence System (CDIS), was built around the NLToolset [2], which was originally developed by GE and is now being developed and supported by Lockheed-Martin. Early results showed that the system was performing better than the human analysts in all aspects.
Multivariate Statistical Process Control Charts and the Problem of Interpretation: A Short Overview and Some Applications in Industry (2009)

Woodall and Montgomery [35] in a discussion paper, state that multivariate process control is one of the most rapidly developing sections of statistical process control. Nowadays, in industry, there are many situations in which the simultaneous monitoring or control, of two or more related quality - process characteristics is necessary. Process monitoring problems in which several related variables are of interest are collectively known as Multivariate Statistical Process Control (MSPC).This article has three parts. In the first part, we discuss in brief the basic procedures for the implementation of multivariate statistical process control via control charting. In the second part we present the most useful procedures for interpreting the out-of-control variable when a control charting procedure gives an out-of-control signal in a multivariate process. Finally, in the third part, we present applications of multivariate statistical process control in the area of industrial process control, informatics, and business.
File Systems in User Space (1993)

Distraction osteogenesis is both a valuable clinical technique and a useful tool for investigating the basic mechanisms involved in bone tissue regeneration. Here we describe the development of a murine model of this procedure that can be used in transgenic animals to investigate the role of specific genes in tissue regeneration. Ring fixators were applied to the lower leg of 12 normal adult male mice. An osteotomy was made in the diaphysis of the tibia, and 7 days after the operation the bone fragments were distracted by 0.25 mm twice a day for 10 days. Specimens were examined immediately at the end of distraction and after 14-70 days of consolidation. At the end of distraction, the distraction gap was filled with fibroblast-like cells arranged longitudinally. After 14 days of consolidation, there was radiographical evidence of bone formation in the distraction gap and, after 28 days of consolidation, the bone fragments were fused with regenerated bone. By 70 days of consolidation, the regenerated bone had been almost completely remodeled and the intramedullary canal reestablished. This study is the first to report consolidation of the distraction gap with regenerated bone in a murine model of distraction.
Sweep Efficiency in CO2 Foam Simulations with Oil (2011)

We simulate gravity segregation and sweep in foam EOR in miscible and immiscible displacements of oil to investigate the effect of oil on foam sweep and the usefulness of simple models designed to predict the extent of gravity override with foam. Comparis
La Universidad y la excelencia académica (2006)

Liver ischemia/reperfusion (I/R) injury has high mortality due to the intense inflammatory process occurs in the liver. However, the pathological mechanism underlying I/R injury is still not clear. Recent works showed that circular RNAs play critical roles in many human diseases. In this study, the occurrence of liver I/R injury was validated by an analysis of the blood samples and hematoxylin-eosin (HE) staining of liver tissues. Total RNA was purified and followed by RNA-seq in the purpose of screening the circRNAs in significant differentially expression, which were validated by quantitative PCR. GO and KEGG analysis were performed to determine the function of these differentially expressed circular RNAs. The circular structure of the circRNA was validated with gel electrophoresis and RNase R treatment. We found that some circular RNAs were differentially expressed in Liver I/R mouse models through bioinformatics analysis. These circular RNAs play roles in biological process, cellular component, and molecular function through GO analysis. Meanwhile, Hippo signaling pathway was found to be correlated with circular RNAs function in I/R models by KEGG analysis. To further validate bioinformatics data, two up-regulated and three down-regulated circular RNAs were confirmed in I/R models. The circularity of these differentially expressed circular RNAs was validated through gel electrophoresis and RNase R treatment. In summary, this work provides new insights into the mechanism underlying pathogenesis of liver I/R injury, providing new and potentially efficient targets against I/R injury.
Empirical Correlations between Thermodynamic Properties and Intermolecular Forces (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEmpirical Correlations between Thermodynamic Properties and Intermolecular ForcesMartin S. Westwell, Mark S. Searle, David J. Wales, and Dudley H. WilliamsCite this: J. Am. Chem. Soc. 1995, 117, 18, 5013–5015Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/ja00123a001https://doi.org/10.1021/ja00123a001research-articleACS PublicationsRequest reuse permissionsArticle Views1525Altmetric-Citations200LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Compact, efficient, low-cost diode power conditioning for laser inertial fusion energy (2011)

This year fusion ignition and gain are expected on the National Ignition Facility at LLNL. The pathway to inertial fusion energy begins by addressing high average power operation of the diode pumped solid state laser system, target chamber, target injection and tracking, target mass production, blanket, and the balance of plant. To meet efficiency requirements, the power conditioning for the laser diodes must be compact and efficient. A diode pulser has been designed to meet these specifications, operate efficiently, and provide a means to minimizing cost and size for the estimated 4.4 million pulsers needed for a power plant.
Effect of nutritional state on the utilization of fatty acids for hepatitic triacylglycerol synthesis and secretion as very-low-density lipoprotein (1991)

The mass of very-low-density-lipoproteins (VLDL) triacylglycerol secreted from isolated hepatocytes was dependent on the nutritional state of the donor rats, and declined in the order sucrose-fed greater than chow-fed greater than polyunsaturated-fat-fed greater than starved. This was the case irrespective of the presence or absence of exogenous oleate. The contribution of newly synthesized fatty acids to the total mass of VLDL triacylglycerol also declined in the above order, and reflected the relative rates of fatty acid synthesis de novo in each of the groups. The contribution of exogenous oleate to VLDL triacylglycerol varied in a manner similar to that for newly synthesized fatty acid. However, the contribution either of exogenous oleate or of newly synthesized fatty acid never exceeded 17-20% of the total VLDL triacylglycerol fatty acid even in the sucrose-fed animals. The increased contribution of newly synthesized fatty acids in the sucrose-fed group was not sufficient to account for the increase in the total mass of VLDL triacylglycerol secreted. These results suggest that: (a) changes in the rate of triacylglycerol secretion are not a direct consequence of variations in the rate of fatty acid synthesis de novo; (b) in the short term, most of the triacylglycerol required for VLDL assembly and secretion is derived from an intracellular storage source: (c) the distribution of newly synthesized triacylglycerol between the cytosolic and secretory pools was similar irrespective of the source of fatty acids (i.e. synthesized de novo or exogenous).
Comparison between Experimental Measurement and Numerical Analysis of Warpage in PBGA Package and Assembly with the Consideration of Residual Strain in the Molding Compound (2006)

The purpose of this study is to experimentally and numerically investigate thermal and residual deformations of plastic ball grid array (PBGA) package and assembly. In the experiments, a full-field shadow moire with a sensitivity of 29.2 mum/fringe is used for measuring their real-time out-of- plane deformations (warpages) during heating and cooling conditions. The elastic moduli (Es) and coefficients of thermal expansion (CTEs) for epoxy molding compound (EMC) and organic substrate are measured in terms of temperatures by dynamic mechanical analyzer (DMA) and thermo-mechanical analyzer (TMA), respectively. And a finite element method with the input of these measured material properties is employed to numerically simulate the thermally-induced deformations of them, in order to understand the insight of mechanics. The full-field warpages of the PBGA package and assembly from shadow moire were documented during the temperature cycling (from room temperature to 220degC). It is interesting that the maximum warpages with concave shape for both the package and assembly occur at near 155degC during this thermal cycling, (rather than with convex shape at room temperature by assuming the warpage-free (or stress-free) temperature is at 175degC of molding). This issue has been resolved through the finite element analyses by cooperating with the residual strain (stress) in the EMC of the package, which is obtained by measuring the residual and thermal deformations of the detached EMC/die bi-material structure. This residual strain of the EMC maybe comes either from the chemical shrinkage of the EMC curing, or more possible stress relaxation of the EMC during the first solder reflow of attaching the solder balls. Furthermore, the thermal deformations for both the package and assembly were fully addressed by the finite element models. Both consistent results indicate that the more severe coplanarity with the value of about 275 mum at the corner of the substrate with the size of 40 times 40 times 1.7 mm occurs at near 155degC, due to the Tg and residual strains of the EMC, rather than at the room temperature. This severe coplanarity can be mitigated by lowering the residual shrinkage strain. And the warpage of the PBGA assembly coincides with the package at the temperature beyond 155degC (highly resulting from apparent creep of the solder balls), but is larger than that of the package below 155degC, due to constraint of the PCB through less-pronounced creep solder balls.
Integration of Paths--A Faithful Representation of Paths by Noncommutative Formal Power Series (1958)

Kuo-Tsai Chen, Integration of Paths--A Faithful Representation of Paths by Noncommutative Formal Power Series, Transactions of the American Mathematical Society, Vol. 89, No. 2 (Nov., 1958), pp. 395-407
Continuous Rearing of the Pea Aphid, Acyrthosiphon pisum,1 on a Holidic Diet2 (1971)

Journal Article Continuous Rearing of the Pea Aphid, Acyrthosiphon pisum, on a Holidic Diet Get access David H. Akey, David H. Akey Department of Entomology, University of Wisconsin, Madison 53706. Search for other works by this author on: Oxford Academic Google Scholar Stanley D. Beck Stanley D. Beck Department of Entomology, University of Wisconsin, Madison 53706. Search for other works by this author on: Oxford Academic Google Scholar Annals of the Entomological Society of America, Volume 64, Issue 2, 15 March 1971, Pages 353–356, https://doi.org/10.1093/aesa/64.2.353 Published: 15 March 1971 Article history Received: 01 June 1970 Published: 15 March 1971
Automatioc Density Measurement System Using Optical Lens in High Speed Textile Fabrication Process (1998)

The density of fabric is a very important parameter in many fabric production processes. However, in the textile fabrication factories, textile density measurement process has been done inefficiently by handicraft. Thus, exact textile density measurement process is necessary to fabricate high quality textile through weft straighten. In this paper, we propose an automatic textile density measurement system to measure textile density automatically and to improve fabrication efficiency. The proposed system uses cylindrical lens to optically scan the weftl information of the fabric as well as convex lens to enlarge the weft images. The proposed system improves textile quality and provides constant density value to the whole textile range in the high speed fabrication process
On the coexistence of IEEE 802.11ac and WAVE in the 5.9 GHz Band (2014)

The IEEE Wireless Access in Vehicular Environment, or WAVE, system uses 5.9 GHz band. Recently, however, the FCC announced its intention to share the band for WLANs based on new standards such as IEEE 802.11ac. In this article, we discuss the problems in the possible coexistence scenario of WAVE and WLAN, such as direct competition between WLAN and WAVE devices for bandwidth and the hidden terminal problem. The problems are exacerbated by the different bandwidth used by the two technologies, so the only usable sensing method between them is energy detection. In this article, we consider one way to address the problems within the current standards framework, which is the combined control of interframe space and the receiver sensitivity on the WLAN devices cued by the energy detection.