gebhart/patrepeval huggingface dataset:
Antineoplastic Effects of N-3 Polyunsaturated Fatty Acids in Combination With Drugs and Radiotherapy: Preventive and Therapeutic Strategies (2009)

Many data support the beneficial effect of n-3 polyunsaturated fatty acids (PUFAs) as chemopreventive and chemotherapeutic agents in the treatment of several chronic pathologies including cancer. Different molecular mechanisms have been proposed to explain their effects, including alterations in arachidonic acid oxidative metabolism and metabolic conversion of n-3 PUFAs to novel discovered bioactive derivatives; modification of oxidative stress; changes in cell membrane fluidity and structure and altered metabolism and function of membrane proteins. Considerable knowledge has been recently gathered on the possible beneficial effects of n-3 PUFAs administered in combination with different antineoplastic drugs and radiotherapy against melanoma, leukemia, neuroblastoma, and colon, breast, prostate, and lung cancer. The efficacy of these combinations has been demonstrated both in vivo and in vitro, and clinical trials have also been conducted. The aim of this review is to analyze all the n-3 PUFA combinations investigated so far, their efficacy, and the possible molecular mechanisms involved. It would be highly auspicable that the detailed analysis of the literature in this field could further support the common use of n-3 PUFAs in combination with other chemopreventive agents and warrant more clinical investigations designed to test the effectiveness of n-3 PUFA treatments coupled with conventional antineoplastic therapies.
Functional capacity evaluation: an empirical approach. (1980)

This paper presents an empirical approach to selecting activities of daily living (ADL) to assess the functional capacity of noninstitutionalized individuals with polyarticular disability. The results of structural analyses illustrate the feasibility of substantially reducing the task of assessing functional capacity with a subset of ADL items without sacrificing the comprehensiveness of the assessment. The analyses reveal 5 common functional categories: physical mobility, transfers, home chores, kitchen chores, and personal care, which account for over 50% of the variance in the data.
Adaptive Inverse Perspective Mapping for lane map generation with SLAM (2016)

This paper proposes an adaptive Inverse Perspective Mapping (IPM) algorithm to obtain accurate bird's-eye view images from the sequential images of forward looking cameras. These images are often distorted by the motion of the vehicle; even a small motion can cause a substantial effect on bird's-eye view images. In this paper, we propose an adaptive model for the IPM to accurately transform camera images to bird's-eye view images by using motion information. Using motion derived from the monocular visual simultaneous localization and mapping (SLAM), experimental result shows that the proposed approaches can provide stable bird's-eye view images, even with large motion during the drive.
The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells (2017)

Oleandrin is a glycoside that inhibits the ubiquitous enzyme Na<sup>+</sup>/K<sup>+</sup>-ATPase. In addition to its known effects on cardiac muscle, recent <i>in vitro</i> and <i>in vivo</i> evidence highlighted its potential for anticancer properties. Here, we evaluated for the first time the effect of oleandrin on brain tumors. To this aim, mice were transplanted with human or murine glioma and analyzed for tumor progression upon oleandrin treatment. In both systems, oleandrin impaired glioma development, reduced tumor size, and inhibited cell proliferation. We demonstrated that oleandrin does the following: (1) enhances the brain-derived neurotrophic factor (BDNF) level in the brain; (2) reduces both microglia/macrophage infiltration and CD68 immunoreactivity in the tumor mass; (3) decreases astrogliosis in peritumoral area; and (4) reduces glioma cell infiltration in healthy parenchyma. In BDNF-deficient mice (bdnftm1Jae/J) and in glioma cells silenced for TrkB receptor expression, oleandrin was not effective, indicating a crucial role for BDNF in oleandrin's protective and antitumor functions. In addition, we found that oleandrin increases survival of temozolomide-treated mice. These results encourage the development of oleandrin as possible coadjuvant agent in clinical trials of glioma treatment.<b>SIGNIFICANCE STATEMENT</b> In this work, we paved the road for a new therapeutic approach for the treatment of brain tumors, demonstrating the potential of using the cardioactive glycoside oleandrin as a coadjuvant drug to standard chemotherapeutics such as temozolomide. In murine models of glioma, we demonstrated that oleandrin significantly increased mouse survival and reduced tumor growth both directly on tumor cells and indirectly by promoting an antitumor brain microenvironment with a key protective role played by the neurotrophin brain-derived neurotrophic factor.
Study of iridium and iridium--tungsten alloys for space radioisotopic heat sources. [Up to 4% W; fabrication; microstructure; tensile; oxidation; compatibility; fractures] (1976)

The physical and mechanical properties of iridium and iridium-tungsten alloys containing up to 4% tungsten were evaluated as potential cladding materials in space isotopic heat sources. The iridium--tungsten alloys are readily fabricable and are compatible with graphite, low-pressure oxygen, and simulated heat source environments up to at least 1300/sup 0/C. The solubility of oxygen and carbon in the alloys appears to be quite low, at a level of 5 ppM for oxygen and 10 ppM for carbon up to 1300/sup 0/C. The Ir--2% W has good oxidation resistance below 1000/sup 0/C. No internal oxidation or grain-boundary penetration was observed in this alloy. Also, alloying with 2% tungsten raises the recrystallization temperature of iridium by 400/sup 0/C and retards the grain growth at high temperatures. Tensile properties were determined as a function of test temperature up to 1400/sup 0/C. Alloying with tungsten increases the yield strength and slightly lowers the ductility. The ductilities of the alloys increase steadily with test temperature. In connection with this increase, the fracture mode changes from grain-boundary separation to transgranular fracture at temperatures around 800/sup 0/C and finally to ductile rupture with close to 100% reduction in area above 1000/sup 0/C. The Ir--2% alloy has the best toughness because of its high strength and good ductility at 1370/sup 0/C. The yield strength and fracture behavior of iridium and iridium--tungsten alloys were found to be very sensitive to trace impurities with concentrations in the ppM range. 21 tables, 20 figures.
A comparative study of the seed polyphenols of the genus <i>Theobroma</i> (1960)

Research Article| February 01 1960 A comparative study of the seed polyphenols of the genus Theobroma L. A. Griffiths L. A. Griffiths 1Regional Research Centre, Imperial College of Tropical Agriculture, Trinidad Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1960) 74 (2): 362–365. https://doi.org/10.1042/bj0740362 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation L. A. Griffiths; A comparative study of the seed polyphenols of the genus Theobroma. Biochem J 1 February 1960; 74 (2): 362–365. doi: https://doi.org/10.1042/bj0740362 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1960 CAMBRIDGE UNIVERSITY PRESS1960 Article PDF first page preview Close Modal You do not currently have access to this content.
Coherent radar performance estimation (1993)

Introduction to coherent radar systems stability and stable sources effects of I/Q errors timing jitter effects A-to-D conversion effects nonlinear effects in fourier transfer processing motion compensation fundamentals MTI systems pulsed Doppler radar pulse compression waveforms and pulse compression error effects stepped frequency and ISAR imaging systems FMCW systems coherent tracking phase noise testing radar component and subsystem tests coherent radar system tests - techniques, considerations and equipment.
Correlation Between Fatigue Crack Growth Rate and Fatigue Striation Spacing in AISI 9310 (AMS 6265) Steel (1981)

Fatigue crack growth data were obtained for an AISI 9310 (AMS 6265) steel under various conditions. The effects of stress ratio, frequency, environment, and carbon content (strength) on both the fatigue fracture topography and the fatigue crack growth rate were studied. A good correlation was obtained between the fatigue striation spacing and the macroscopic crack growth rate for crack growth rates ranging from 10−4 to 10−3 mm/cycle.
Advanced Procedure for the Preparation of <i>cis</i>‐1,2‐Dialkylcyclopropanols – Modified Ate Complex Mechanism for Titanium‐Mediated Cyclopropanation of Carboxylic Esters with Grignard Reagents (2007)

Abstract A procedure for the preparation of cis ‐1,2‐dialkylcyclopropanols by titanium(IV) alkoxide‐mediated cyclopropanation of carboxylic esters with Grignard reagents, involving the addition of 1.5 equiv. of a higher homologue of ethylmagnesium halide to a mixture of 1 equiv. of carboxylic ester, 1 equiv. of titanium(IV) isopropoxide, and 1.5 equiv. of methylmagnesium halide in ether or tetrahydrofuran at room temperature, has been elaborated. This procedure minimizes the formation of secondary alcohol side products with chromatographic retention factors close to those of the cis ‐1,2‐disubstituted cyclopropanols. Inhibitory action of carboxylic esters toward the reduction of titanium(IV) isopropoxide with Grignard reagents was observed. This observation, along with some other data, allowed us to suggest a modified ate complex mechanism for the cyclopropanation, proceeding via the corresponding octahedral titanium intermediates. In the context of this mechanism, a suitable explanation for the necessity to use an additional equivalent of Grignard reagent in a stoichiometric version of the reaction was found and experimentally verified. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Trust Me on This (2014)

Successful completion of Algebra I is essential for all students in the United States, and is a high-stakes, gatekeeper course. However, a substantial proportion of students from marginalized groups do not gain access to Algebra I until much later in their academic careers than their middle-class, White, English-speaking, fully able peers. This is not only an issue of tracking individual students, but is also indicative of a more profound, institutionalized set of practices. Using a purposive sample, this research highlights the ways middle school mathematics teachers make tracking and student-placement decisions. Teachers in this qualitative research (n=10) reported a heavy reliance on their own omniscience.
THE INTERACTION OF HYDROCHLOROTHIAZIDE WITH SPIRAPRIL (1994)

In an open-label, randomized trial using a 3 x 3 Latin square design, single doses of 24 mg of the ACE inhibitor spirapril, or 50 mg hydrochlorothiazide, or their combination were given to 18 healthy male volunteers. No alteration in the area under plasma drug concentration curve (AUC), peak plasma level, time to peak level, or elimination half-life was detected for hydrochlorothiazide, spirapril, or its active metabolite, spiraprilat, during combination therapy. It was concluded that there was no significant effect of spirapril on single-dose kinetics of hydrochlorothiazide, nor of hydrochlorothiazide on single-dose kinetics of spirapril. Significant reductions in systolic blood pressure were noted 2--6 h after either spirapril or combination treatment, but no evidence of any synergistic effect of single-dose effects on blood pressure was seen during combination therapy.
On the occurrence of Unio complanatus Sol., in Michigan (1889)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Determination of Trace Sulfur Hexafluoride in Nitrogen Trifluoride Gas by Gas Chromatography-Mass Spectrometry (2003)

The trace sulfur hexafluoride in high pure nitrogen trifluoride gas was determin by selective ion monitor (SIM) mode. The analysis is carried out on a poraPLOT Q capillary column (5 μm×0.32 mm×30 m) and QP5000 GC/MS. The quantitative selected ion is m/z 127. The interferece to the determination of selected ion was studied. The linear range is from 2.0 to 100 μL/L with relative coefficient of 0.9996. The mininum detection limit is 0.2 μL/L. The average recovery is 92.70%~97.04%. The intra-day and inter-day relative standard deviation(s r) of SF 6 is less than 4.17% and 5.33%, respectively.
Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: Effects on proliferation and apoptosis (1998)

The effect of individual administration of low doses of highly purified eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (1 g/kg body weight) on the growth of Morris hepatocarcinoma 3924A transplanted in ACI/T rats was investigated. Both EPA and DHA inhibited growth of the hepatocarcinoma (50% reduction of tumor weight or volume at the 19th day after transplantation for both of the n-3 PUFA groups). EPA treatment reduced the percentage of proliferating tumor cells labeled with BUdR (10-fold), whereas DHA did not. Conversely, DHA supplementation induced a doubling of the number of cells undergoing apoptosis (labeled by TUNEL), whereas EPA treatment was much less effective. Analysis of changes in phospholipid fatty acids in tumor-cell membranes after both treatments with EPA and DHA showed a significant reduction in arachidonic-acid levels. EPA and docosapentaenoic acid (DPA), its elongation product, were increased in the phospholipids from EPA-treated animals. DHA and EPA, but not DPA, were increased in the DHA-treated group. It is concluded from the results of the present study that the anti-tumoral effect of EPA is related mainly to its inhibition of cell proliferation, whereas that of DHA corresponds with its induction of apoptosis. The alterations in fatty-acid composition induced by EPA or DHA appear to be factors underlying their differential actions on cell proliferation and apoptosis.
Haplotype Analysis Improved Evidence for Candidate Genes for Intramuscular Fat Percentage from a Genome Wide Association Study of Cattle (2011)

In genome wide association studies (GWAS), haplotype analyses of SNP data are neglected in favour of single point analysis of associations. In a recent GWAS, we found that none of the known candidate genes for intramuscular fat (IMF) had been identified. In this study, data from the GWAS for these candidate genes were re-analysed as haplotypes. First, we confirmed that the methodology would find evidence for association between haplotypes in candidate genes of the calpain-calpastatin complex and musculus longissimus lumborum peak force (LLPF), because these genes had been confirmed through single point analysis in the GWAS. Then, for intramuscular fat percent (IMF), we found significant partial haplotype substitution effects for the genes ADIPOQ and CXCR4, as well as suggestive associations to the genes CEBPA, FASN, and CAPN1. Haplotypes for these genes explained 80% more of the phenotypic variance compared to the best single SNP. For some genes the analyses suggested that there was more than one causative mutation in some genes, or confirmed that some causative mutations are limited to particular subgroups of a species. Fitting the SNPs and their interactions simultaneously explained a similar amount of the phenotypic variance compared to haplotype analyses. Haplotype analysis is a neglected part of the suite of tools used to analyse GWAS data, would be a useful method to extract more information from these data sets, and may contribute to reducing the missing heritability problem.
Random Positive-Only Projections: PPMI-Enabled Incremental Semantic Space Construction (2016)

We introduce positive-only projection (PoP), a new algorithm for constructing semantic spaces and word embeddings. The PoP method employs random projections. Hence, it is highly scalable and computationally efficient. In contrast to previous methods that use random projection matrices R with the expected value of 0 (i.e., E(R) = 0), the proposed method uses R with E(R) > 0. We use Kendall's b correlation to compute vector similarities in the resulting non-Gaussian spaces. Most importantly, since E(R) > 0, weighting methods such as positive pointwise mutual information (PPMI) can be applied to PoP-constructed spaces after their construction for efficiently transferring PoP embeddings onto spaces that are discriminative for semantic similarity assessments. Our PoP-constructed models, combined with PPMI, achieve an average score of 0.75 in the MEN relatedness test, which is comparable to results obtained by state-of-the-art algorithms.
Modularly Integrated MEMS Technology (2006)

Process design, development and integration to fabricate reliable MEMS devices on top of VLSI-CMOS electronics without damaging the underlying circuitry have been investigated throughout this dissertation. Experimental and theoretical results that utilize two "Post-CMOS" integration approaches will be presented. The first integration approach uses SiGe MEMS technology for the "Post-CMOS" monolithic integration of the MEMS devices with electronics. Interconnects between SiGe MEMS and Al-TiN metallized layers have been characterized and optimized. A thorough study on Boron doping and Ge content effects on the electrical, mechanical, and chemical properties of SiGe MEMS technology has been performed. Two CMOS-compatible micromachining fabrication procedures have been developed for RF and inertial sensing MEMS applications. First, a process flow that uses Ge ashing technique to define nanogaps in SiGe electrostatic MEMS transceivers for wireless communication applications has been demonstrated. Second, a multilayer SiGe MEMS process flow has been implemented for the fabrication of a freely moving disk used to pave the way towards an integrated electrostatically levitated disk sensor system for low loss inertial sensing applications. The sensor system is comprised of a disk-shaped proof-mass that is to be electrostatically suspended between sense and drive electrodes located above, below, and at the sides of the disk. The second "Post-CMOS" integration employs the state-of-art "back-end" materials already available in the integrated circuitry to fabricate the MEMS devices. Copper-based MEMS technology is used for the fabrication of low loss RF MEMS switches directly on top of the electronics. A model accounting for multilayer cantilever beam deflection suitable for MEMS devices fabricated with conventional "back-end" materials was derived. Experimental results characterizing stress gradients in copper-based RF MEMS switches will be presented. The effect of Physical Vapor Deposition (PVD), Atomic Layer Deposition (ALD) deposited TaN films, and compressive SiN films on beam deformation have been studied, as well as the effect of annealing on the reliability properties of the RF MEMS switches
A Fast, High Resolution Chirp Transform Spectrometer For Atmospheric Remote Sensing From Space (2005)

Atmospheric research from space is gaining more and more significance. The millimeter and sub-millimeter spectroscopy has become an important tool for the measurement of distribution profiles for the solution of urgent environmental problems (i.e. depletion of the ozone layer). The equipment necessary for a heterodyne spectrometer is a radiometer front-end and a back-end for spectrum analysis. Candidate concepts for spectrum analysers are filterbanks, autocorrelators and acousto-optic spectrometers (AOS). However, constraints imposed by mass, volume or excessive power consumption and partial instability reduce their efficiency for use in space.
The Interaction of Roles, Resources, and Organizational Structures in Creative Work (2010)

Creativity is known to be located at both the individual and group levels. We look at the case of videogame development, as an instance of project level creativity. We focus in particular on the design of the artifact. By examining the loci of creativity at the individual and group levels, we shed light on the roles and tasks of the designer, and on the organizational group structure known as the design cabal. In comparing the two extremes, we discover that the lack of organizational resources (namely, well known designers) leads in certain projects to the adoption of cabals or cabal-like approaches. Secondly, we illustrate the variety of design roles. Designers can be classified into three types (based on their roles): prototyping creators, vision creators, and implementing designers. Thus, the seemingly singular role of the designer is shown to be variable, defined by the capability of the designer and the tasks required. In the model that emerges, these roles ultimately interact with the resource requirements of the artifact to produce organizational structures.
The effect of α-phenyl-<i>N-t</i>-butylnitrone on ionizing radiation-induced apoptosis in U937 cells (2005)

Ionizing radiation induces the production of reactive oxygen species (ROS), which play an important causative role in apoptotic cell death. alpha-Phenyl-N-t-butylnitrone (PBN) is one of the most widely used spin-trapping compounds for investigating the existence of free radicals in biological systems. We investigated the effects of PBN on ionizing radiation-induced apoptosis in U937 cells. Upon exposure to 2 Gy of gamma-irradiation, there was a distinct difference between the control cells and the cells pre-treated with 2 mM PBN for 2 h in regard to apoptotic parameters, cellular redox status, mitochondria function and oxidative damage to cells. PBN effectively suppressed morphological evidence of apoptosis and DNA fragmentation in U937 cells exposed to ionizing radiation. The [GSSG]/[GSH+GSSG] ratio and the generation of intracellular ROS were higher and the [NADPH]/[NADP+ +NADPH] ratio was lower in control cells compared to PBN-treated cells. The ionizing radiation-induced mitochondrial damage reflected by the altered mitochondrial permeability transition, the increase in the accumulation of ROS, and the reduction of ATP production were significantly higher in control cells compared to PBN-treated cells. PBN pre-treated cells showed significant inhibition of apoptotic features such as activation of caspase-3, up-regulation of Bax and p53, and down-regulation of Bcl-2 compared to control cells upon exposure to ionizing radiation. This study indicates that PBN may play an important role in regulating the apoptosis induced by ionizing radiation presumably through scavenging of ROS.
ECT in Texas (1998)

ECT in Texas is performed by a small minority of psychiatrists and is unavailable to many patients who need it. It is most accessible to white patients who receive care outside the public sector. Our data support the common finding that ECT is generally safe and effective.
Gas Turbines and Cogeneration (1996)

Gas turbine based cogeneration system provides efficient and reliable power and heat with lesser impact on the environment. Cogeneration system is more economical because of its high system efficiency, availability, durability and low energy cost.
Nucleotide sequence of a maize U6 gene (1990)

The nucleotide sequence of a Zea mays U6 gene is presented. A lambda clone containing the U6 gene was isolated from the maize inbred line W22. A subgenomic library was constructed in lambda Zap II (1). The library was screened with a synthetic oligomer complementary to the base sequence 18-39 of the broad bean U6 RNA (2).