gebhart/patrepeval huggingface dataset:
Timing of coronary revascularization after acute myocardial infarction. Early and late results in patients revascularized within seven weeks. (1984)

Evidence of ischemia after acute myocardial infarction is a serious complication. If angiography reveals significant coronary artery disease, the precise timing of myocardial revascularization may be of critical importance. From 1978 through 1982, 174 patients underwent myocardial revascularization within 7 weeks of a documented myocardial infarction. The male:female ratio was 138:36, the average age was 58 +/- 1 (SEM) years; and the ejection fractions averaged 41% +/- 1%. Forty-four (25%) patients required preoperative intra-aortic balloon pump support, and an additional 18 (10%) required intra-aortic balloon pumping to be separated from cardiopulmonary bypass. An average of 2.9 +/- 0.1 vessels per patient were bypassed. The hospital mortality for these 174 patients was 16%. When mortalities were categorized according to the postinfarction week in which operation was performed, hospital mortality fell from 46% for those patients operated upon within 1 week of infarction to 6% for those patients operated upon 7 weeks after infarction. Of those patients operated upon within the first week after infarction, 23% were in cardiogenic shock and 62% required preoperative balloon pumping. Clearly the most critically ill patients were operated upon during the early postinfarction period. However, there was a marked difference in survival when patients in each of the seven weekly groups were classified according to ejection fraction. All patients with an ejection fraction greater than or equal to 50% (50 patients) operated upon at any time after infarction survived their hospital course, with only one late death. Conversely, among the 124 patients with an ejection fraction less than 50% operated upon during this 7 week interval, there were 27 (22%) hospital deaths. In this latter group, survival rates steadily improved if revascularization was performed at a time more remote from the infarction. The difference in early and late survival rates of patients operated upon with an ejection fraction greater than or equal to 50% compared to patients with an ejection fraction less than 50% is highly significant (p less than 0.001). We conclude that myocardial revascularization is safe at any time after myocardial infarction for those individuals with an ejection fraction greater than or equal to 50%. However, if the ejection fraction is less than 50%, then operation after myocardial infarction should be delayed at least 4 weeks.
Discrimination studies using short-period P waves at upper mantle distances. Annual report, January 1986-January 1987 (1988)

This report reviews the properties of seismograms recorded at upper mantle distances in stable continental region such as northwest Eurasia in order to examine how well current models predict the general behavior of the observations and to see how much unmodeled energy, or noise, is present. In general The proposed models for the region predict the major arrivals observed in the data. For explosions, there are few distinct arrivals that are not associated with some predicted upper mantle phase. However, noise levels (or code amplitudes), are large, since each arrival has a code associated with it that adds constructively at the receiver. Use predicted coda amplitudes, in a Pearce algorithm to discriminate on the basis of focal mechanism. Given good azimuthal coverage of an event (e.g., 3 of 4 quadrants), the observed complexity of the explosion seismograms is incompatible with that predicted for earthquakes at depth using simple models for the reflection of the depth phases pP and sP. These results are similar to previous findings that considered teleseismic data.
Highly Penetrant Alterations of a Critical Region Including BDNF in Human Psychopathology and Obesity (2012)

CONTEXT Brain-derived neurotrophic factor (BDNF) is suspected of being a causative factor in psychiatric disorders based on case reports or studies involving large structural anomalies. OBJECTIVE To determine the involvement of BDNF in human psychopathology. DESIGN Case-control study. SETTING Microarray-based comparative genomic hybridization data from 7 molecular diagnostic centers including 38 550 affected subjects and 28 705 unaffected subjects. PATIENTS Subjects referred to diagnostic screening centers for microarray-based comparative genomic hybridization for physical or cognitive impairment. MAIN OUTCOME MEASURES Genomic copy number gains and losses. RESULTS We report 5 individuals with psychopathology and genomic deletion of a critical region including BDNF. The defined critical region was never disrupted in control subjects or diagnostic cases without developmental abnormalities. CONCLUSION Hemizygosity of the BDNF region contributes to variable psychiatric phenotypes including anxiety, behavioral, and mood disorders.
ChemInform Abstract: Structure Determination of the Esperamicins (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Inter‐ and Intramolecular Reductive Coupling Reactions: An Approach to the Phorbol Skeleton. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis (2019)

Periapical periodontitis results from pulpal infection leading to pulpal necrosis and resorption of periapical bone. The current treatment is root canal therapy, which attempts to eliminate infection and necrotic tissue. But, in some cases periapical inflammation doesn't resolve even after treatment. Resolvins belongs to a large family of specialized pro-resolving lipid mediators that actively resolves inflammation signaling via specific receptors. Resolvin D2 (RvD2), a metabolite of docosahexaenoic acid (DHA), was tested as an intracanal medicament in rats <i>in vivo</i>. Mechanism was evaluated in rat primary dental pulp cells (DPCs) <i>in vitro</i>. The results demonstrate that RvD2 reduces inflammatory cell infiltrate, periapical lesion size, and fosters pulp like tissue regeneration and healing of periapical lesion. RvD2 enhanced expression of its receptor, GPR18, dentin matrix acidic phosphoprotein 1 (DMP1) and mineralization <i>in vivo</i> and <i>in vitro</i>. Moreover, RvD2 induces phosphorylation of Stat3 transcription factor in dental pulp cells. We conclude that intracanal treatment with RvD2 resolves inflammation and promoting calcification around root apex and healing of periapical bone lesions. The data suggest that RvD2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions.
<title>When Is Inhouse Service Cost Effective?</title> (1980)

The benefits and structure of the inhouse service program at the University of Alabama in Birmingham are reviewed. The program, when analyzed and compared to contracted service, realizes a savings of from $190,000 to $250,000 per year. Scaling the program to smaller hospitals indicates that inhouse service becomes cost effective when 11/2 million dollars or more of equipment is involved. For remotely located hospitals the cost effective equipment figure may be somewhat less.
ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response (2001)

High density lipoproteins (HDL) mediate reverse cholesterol transport as well as the clearance of oxidation products or inflammatory mediators, thereby contributing to tissue integrity. The decrease in HDL in inflammation has been attributed to decreased lecithin:cholesterol acyltransferase activity, whereas the role of phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein has not been analyzed in detail. We have studied the activities of HDL-modifying proteins and the heterogeneity of HDL in healthy control subjects and three groups of postsurgery patients: no bacterial infection (group 1), bacterial focus and systemic inflammatory response (group 2), and severe sepsis (group 3). For all patients, a decrease in total HDL could be demonstrated, with a loss of mainly large, apolipoprotein A-I (apoA-I) HDL particles, an almost total loss of apoC-I, and an increase in apoE HDL (200-500 kDa), which did not contain significant amounts of apoA-I, apoA-II, or apoC-I. PLTP activity was increased in patients of groups 2 and 3, paralleled by a redistribution of PLTP into a population of small (120- to 200-kDa) particles, probably representing PLTP homodimers or lipid-complexed PLTP. In summary, the increase in apoE HDL and PLTP activity may improve the delivery of energy substrates and phospholipids to tissues that must maintain cellular membrane homeostasis under conditions of inflammatory stress.
High power, high speed, single-mode wafer-bonded AlInGaAs-based LW-VCSELs at 70/spl deg/C (2006)

We present wafer-bonded long-wavelength VCSEL operation between 1300 nm and 1330 nm demonstrating 2.5 mW single mode output power at 20degC and 1.7 mW at 70degC. We also show small signal 3-dB bandwidths greater than 10 GHz and 8 GHz at 20degC and 70degC respectively
FIRST RECORD OF ECHINOCHLOA STAGNINA (POACEAE) FOR PUERTO RICO AND KEY TO THE ECHINOCHLOA IN THE WEST INDIES (1993)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Shaker-Clamp Injury to Fruit and Nut Trees: … A research program aimed at causes and control (1965)

Shaker-clamp stresses on fruit and nut trees during mechanical harvesting, which can result in bark injury and susceptibility to disease, were measured under a variety of conditions in these continuing studies. Some of the variables found to affect bark injuries include moisture in both soil and bark, varietal differences, and tree age.
Effects of orally administered<i>Lactobacillus casei</i>DN-114 001 on the composition or activities of the dominant faecal microbiota in healthy humans (2006)

The composition and activities of the faecal microbiota in twelve healthy subjects analysed in a single open study were monitored before (1-week baseline step), during (10 d supplementation step) and after (10 d follow-up step) the ingestion of a fermented milk containing Lactobacillus casei DN-114 001. Fluorescent in situ hybridisation with group-specific DNA probes, real-time PCR using L. paracasei group-specific primers and temporal temperature gradient gel electrophoresis (TTGE) using group-specific primers were carried out, together with bacterial enzyme activity and metabolite analyses to monitor the structure and activities of the faecal microbiota. L. casei DNA was detected in the faeces of all of the subjects by TTGE after 10 d supplementation. Its quantification by real-time PCR showed a 1000-fold increase during the test step compared with initial levels. No major modification in either the dominant members of the faecal microbiota or their activities was observed during the trial. In conclusion, the short-term consumption of a milk product containing L. casei DN-114 001 was accompanied by a high, transient increase in the quantity of this strain in the faeces of all of the subjects without markedly affecting biochemical or bacteriological factors.
Applying queuing theory to the design and optimization of production/service systems (2008)

Queues of people, products, and machines frequently occur in many production systems (goods manufacturing and service supply) and result in significant inefficiencies. For example, machines waiting to be repaired may result in lost production, vehicles forced to wait before being unloaded may delay subsequent shipments, and people made to wait for a service (i.e. bank, hospital, supermarket) may become frustrated which could result in lost future business.\nThis paper discusses the tremendous positive impact of queuing theory (introduced by Erlang and Kendall) on the problems typically found in production systems (e.g. optimal design, resource rationalization, traffic and logistics analysis). \nThe fundamental models in this theory are discussed and then applied to the design and optimization of production systems.\nFinally, a real world application of M/M/n queuing theory is presented involving design optimization of a passenger security screening system in an international airport.
<i>Trichomonas vaginalis</i>: characterization of ornithine decarboxylase (1993)

Ornithine decarboxylase (ODC), the lead enzyme in polyamine biosynthesis, was partially purified from Trichomonas vaginalis and its kinetic properties were studied. The enzyme appears to be of special significance in this anaerobic parasite, since the arginine dihydrolase pathway generates ATP as well as putrescine from arginine. ODC from T. vaginalis had a broad substrate specificity, decarboxylating ornithine (100%), lysine (1.0%) and arginine (0.1%). The enzyme had a pH optimum of 6.5, a temperature optimum of 37 degrees C and was pyridoxal 5'-phosphate-dependent. Attempts to separate ornithine- from lysine-decarboxylating activity by thermal-stability and pH-optima curves were not successful. Although Km values for ornithine and lysine were 109 and 91 microM respectively, and the Vmax values for these substrates were 1282 and 13 nmol/min per mg of protein respectively, the most important intracellular substrate is ornithine, since intracellular ornithine levels are 3.5 times those of lysine and extracellular putrescine levels are 7.5 times those of cadaverine. Ornithine was also an effective inhibitor of lysine-decarboxylating activity (Ki 150 microM), whereas lysine was relatively ineffective as inhibitor of ornithine-decarboxylating activity (Ki 14.5 mM). Crude ODC activity was localized (86%) in the 43,000 g supernatant and 3303-fold purification was obtained by (NH4)2SO4 salting and DEAE-Sephacel, agarose-gel and hydroxyapatite chromatography steps. The enzyme bound difluoro[3H]methylornithine ([3H]DFMO) with a ratio of drug bound to activity of 2500 fmol/unit, where 1 unit corresponds to 1 nmol of CO2 released from ornithine/min. The enzyme had a native M(r) of 210000 (gel filtration), with a subunit M(r) of 55,000 (by SDS/PAGE), suggesting that the trichomonad enzyme is a tetramer. From the subunit M(r) and binding ratio of DFMO, there is about 137 ng of ODC per mg of T. vaginalis protein (0.013%). The significant amount of ODC protein present supports the view that putrescine synthesis in T. vaginalis plays an important role in the metabolism of the parasite.
The Effect of Fiber Winding Angles on the Bending Strength of Fiber-Reinforced Plastic Rods (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Evaluation of rheological and electrical breakdown behaviors of multi-phase polyolefin blends (2014)

Mixing two components in blend systems is an excellent way for developing new materials with improved properties. It is important to understand the thermodynamic characteristics of a composition and microstructure evolution of immiscible polymer blends, which are some of the major factors to control the final properties. The metallocene polyolefins from single site constrained geometry catalysts optimize polymer chain architecture to generate highly uniform polymer molecules with specifically targeted properties. In this paper, the micro-phase structures of polypropylene-based thermoplastic olefins with two types of soft, metallocene polyolefin elastomers were investigated to correlate their rheological and electrical breakdown behavior, which can be utilized to tailor the material performance for wire and cable applications.
Averting the Legacy of Kidney Disease - Focus on Childhood (2016)

World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of adult kidney disease that can begin in earliest childhood. Chronic kidney disease (CKD) in childhood differs from that in adults, as the largest diagnostic group among children includes congenital anomalies and inherited disorders, with glomerulopathies and kidney disease in the setting of diabetes being relatively uncommon. In addition, many children with acute kidney injury will ultimately develop sequelae that may lead to hypertension and CKD in later childhood or in adult life. Children born early or who are small-for date newborns have relatively increased risk for the development of CKD later in life. Persons with a high-risk birth and early childhood history should be watched closely in order to help detect early signs of kidney disease in time to provide effective prevention or treatment. Successful therapy is feasible for advanced CKD in childhood; there is evidence that children fare better than adults, if they receive kidney replacement therapy including dialysis and transplantation, while only a minority of children may require this ultimate intervention. Because there are disparities in access to care, effort is needed so that those children with kidney disease, wherever they live, may be treated effectively, irrespective of their geographic or economic circumstances. Our hope is that World Kidney Day will inform the general public, policy makers and caregivers about the needs and possibilities surrounding kidney disease in childhood.
A Polymeric and Fluorescent Gel for Combinatorial Screening of Catalysts (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Polymeric and Fluorescent Gel for Combinatorial Screening of CatalystsRobert F. Harris, Andrew J. Nation, Gregory T. Copeland, and Scott J. MillerView Author Information Department of Chemistry, Merkert Chemistry Center Boston College, Chestnut Hill, Massachusetts 02467-3860 Cite this: J. Am. Chem. Soc. 2000, 122, 45, 11270–11271Publication Date (Web):October 26, 2000Publication History Received5 September 2000Published online26 October 2000Published inissue 1 November 2000https://pubs.acs.org/doi/10.1021/ja0055763https://doi.org/10.1021/ja0055763rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1033Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Fluorescence,Peptides and proteins,Polymers,Sensors Get e-Alerts
Movement of Nugget on the Multiple Projection Welding (Second Report) (1963)

One of the most conspicuous merits of projection welding is the application of multiple projection welding, whereas prevailing conditions are mostly for single projection welding. In practice, the application of single projection welding is rather rare. In the case of multiple projection welding, if we multiply the welding condition (current, electrode force) based on the single projection welding by the number of projections, an enormous capacity is required and it is not feasible in practice.So, welding current and electrode force have come to be reduced and accordingly the size of projection should be minimized. In case we apply the multiple projection welding with minimized zize of projection, projection nuggest is inclined to move and the weld strength lowers sometimes.It is the purpose of our experiments to scrutinize the cause and mechanism of movement and to obtain the specific index for welding design and procedure.The following experiments were done with the pneumatic pressure fixed to zero and only with the dead weight of upper movable part.i) Series projection weldingii) Moving condition in various welding currents.In the next experiments, the welding machine was set horizontally and carried out varying the following points :i) mass of movable part.ii) size of projection.iii) thickness of mating plate.iv) distance between projections.v) stainless steel.vi) welding current.vii) electrode force.we could find the cause of movement as follows :a) in case the projection fuses, and the mating plate does not melt at the moment.b) no sufficient electrode force which is necessary for the welding part at the moment.c) strong electro-magnetic force by welding current.
Modulation of the Immune Response by Transforming Growth Factor Beta (1992)

For the past several years immunologists have been fascinated by a series of experiments showing that transforming growth factor beta (TGF beta) suppresses T- and B-lymphocyte growth as well as IgM and IgG production by B cells. Moreover, while exerting chemotactic activity on monocytes and inducing expression of interleukin-1 and interleukin-6 by these cells, TGF beta interferes with bacterially induced tumor necrosis factor alpha production, oxygen radical formation and the adhesiveness of granulocytes to endothelial cells. These mechanisms may provide the basis for the effect of TGF beta to prevent the microvascular changes associated with brain edema formation in bacterial meningitis. Given the potential of lymphocytes as well as macrophages to produce TGF beta 1, this cytokine may exert negative feedback signals on the immune response, provided the cytokine is processed from its latent form to the bioactive homodimer. Potent effects of TGF beta have been observed in experimental animals including the inhibition of the generation of virus-specific cytotoxic T cells and antiviral antibodies as well as the diminution of cellular infiltrates with decreased major histocompatibility complex class-II expression and CD8+ T cells in the tissue of virally infected animals. TGF beta may also be of importance in tumor immunology. By the production of bioactive TGF beta as detected in glioblastoma and acute T-cell leukemia, tumor cells may induce an immunodeficiency state and escape immune surveillance. In inflammation, monitoring of TGF beta in the tissue will bring light on the immune regulation in acute and chronic inflammatory diseases.