gebhart/patrepeval huggingface dataset:
Investigation and identification of protein carbonylation sites based on position-specific amino acid composition and physicochemical features (2017)

When comparing to an existing prediction tool, the selected models trained with hybrid features provided a promising accuracy on an independent testing dataset. In short, this work not only characterized the carbonylated substrate preference, but also demonstrated that the proposed method could provide a feasible means for accelerating preliminary discovery of protein carbonylation.
C120+ Isomers from Laser Ablation of Fullerene Films (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTC120+ Isomers from Laser Ablation of Fullerene FilmsJ. M. Hunter, J. L. Fye, N. M. Boivin, and M. F. JarroldCite this: J. Phys. Chem. 1994, 98, 31, 7440–7443Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/j100082a007https://doi.org/10.1021/j100082a007research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: Two‐year results including pharmacokinetics and concomitant hydroxyurea (2013)

We report a prospective, randomized, Phase II study of deferasirox and deferoxamine (DFO) in sickle cell disease patients with transfusional iron overload, with all patients continuing on deferasirox after 24 weeks, for up to 2 years. The primary objective was to evaluate deferasirox safety compared with DFO; long-term efficacy and safety of deferasirox was also assessed. We also report, for the first time, the safety and pharmacokinetics of deferasirox in patients concomitantly receiving hydroxyurea. Deferasirox (n = 135) and DFO (n = 68) had comparable safety profiles over 24 weeks. Adverse events (AEs) secondary to drug administration were reported in 26.7% of patients in the deferasirox cohort and 28.6% in the DFO cohort. Gastrointestinal disorders were more common with deferasirox, including diarrhea (10.4% versus 3.6%) and nausea (5.2% versus 3.6%). The most common AE in the DFO group was injection-site pain irritation, which occurred in 7% of patients. Acute renal failure occurred in one patient on deferasirox who was continued on medication despite progressive impairment of renal function parameters. Serum ferritin levels were reduced in both treatment groups. Patients continuing on deferasirox for up to 2 years demonstrated an absolute median serum ferritin decrease of -614 ng/mL (n = 96). Increasing deferasirox dose was associated with improved response and a continued manageable safety profile. Concomitant hydroxyurea administration (n = 28) did not appear to influence the efficacy, safety (including liver and kidney function), and pharmacokinetic parameters of deferasirox.
Faculty Opinions recommendation of CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. (2007)

Increased numbers of T lymphocytes are observed in the lungs of patients with chronic obstructive pulmonary disease, but their role in the disease process is not known. We investigated the role of CD8+ T cells in inflammatory cell recruitment and lung destruction in a cigarette smoke-induced murine model of emphysema. In contrast to wild-type C57BL/6J mice that displayed macrophage, lymphocyte, and neutrophil recruitment to the lung followed by emphysema in response to cigarette smoke, CD8+ T cell-deficient (CD8-/-) mice had a blunted inflammatory response and did not develop emphysema when exposed to long-term cigarette smoke. Further studies supported a pathogenetic pathway whereby the CD8+ T cell product, IFN-gamma-inducible protein-10, induces production of macrophage elastase (matrix metalloproteinase 12) that degrades elastin, both causing lung destruction directly and generating elastin fragments that serve as monocyte chemokines augmenting macrophage-mediated lung destruction. These studies demonstrate a requirement for CD8+ T cells for the development of cigarette smoke-induced emphysema and they provide a unifying pathway whereby CD8+ T cells are a central regulator of the inflammatory network in chronic obstructive pulmonary disease. PMID: 17548647
New Limits for Solid-State <sup>17</sup>O NMR Spectroscopy:  Complete Resolution of Multiple Oxygen Sites in a Simple Biomolecule (2006)

A solid-state 17O NMR 1H-decoupled double angle rotation (DOR) study of monosodium l-glutamate monohydrate (l-MSG) is reported. It is shown that all eight inequivalent sites can be resolved with DOR line widths ( approximately 65 Hz) approximately 120 times narrower than those in the MAS spectrum. The lines are tentatively assigned on the basis of their behavior under proton decoupling and the isotropic chemical shift and the quadrupole interaction parameter for each extracted by a combination of DOR and 3Q MAS at variable magnetic fields. With a shift range of approximately 45 ppm for these similar oxygen sites and spectral resolution under DOR comparable to that for spin-1/2 nuclei, solid-state 17O NMR should have tremendous potential in the study of biomolecules.
EXCELLENT LONG TERM RENAL FUNCTION IN LIVER TRANSPLANT (LT) RECIPIENTS WITH FASTIDIOUS MONITORING OF TACROLIMUS LEVELS (2010)

Andreoni, K.1; Gerber, D.2; Fair, J.3; johnson, M.4; Watson, R.2; Kozlowski, T.2 Author Information
Surface Morphology and Magnetic Anisotropy (2003)

Understanding the correlation between film structure and its ferromagnetic properties is very important for applications. Despite significant lattice mismatch epitaxial (001) fcc Ni films can be grown on MgO substrates using sputtering or molecular beam epitaxy (MBE). For both types of films it is observed that the average magnetization switching field is very similar but its azimuthal dependence is not. Structural characterization indicates very similar structure for both types of films where subtle differences are responsible for the striking difference in the anisotropy of the magnetic properties.
The Bactericidal Activity of Pediocin PA-1 Is Specifically Inhibited by a 15-mer Fragment That Spans the Bacteriocin from the Center toward the C Terminus (1998)

A 15-mer peptide fragment derived from pediocin PA-1 (from residue 20 to residue 34) specifically inhibited the bactericidal activity of pediocin PA-1. The fragment did not inhibit the pediocin-like bacteriocins sakacin P, leucocin A, and curvacin A to nearly the same extent as it inhibited pediocin PA-1. Enterocin A, however, was also significantly inhibited by this fragment, although not as greatly as pediocin PA-1. This is consistent with the fact that enterocin A contains the longest continuous sequence identical to that of pediocin PA-1 in the region spanned by the fragment. The fragment inhibited pediocin PA-1 to a much greater extent than did the other 29 possible 15-mer fragments that span pediocin PA-1. The results suggest that the fragment-by interacting with the target cells and/or pediocin PA-1-interferes specifically with pediocin-target cell interaction.
Human-centered computing (2006)

Human-Centered Computing (HCC) is a set of methodologies that apply to any field that uses computers, in any form, in applications in which humans directly interact with devices or systems that use computer technologies. In this paper, we give an overview of HCC from a Multimedia perspective. We describe what we consider to be the three main areas of Human-Centered Multimedia (HCM): media production, analysis, and interaction. In addition, we identify the core characteristics of HCM, describe example applications, and propose a research agenda for HCM.
Controllership in Deutschland (2002)

Die Entwicklung des Controlling ist - in Theorie und Praxis - stark an die Entwicklung des Aufgabenfelds von Controllern geknüpft. Die Verbindung erweist sich als so eng, dass sie noch heute akademisc
Ultrafast lasers in chemistry and biology (1994)

In this talk, the principles involved in some applications of ultrafast lasers in chemistry and biology are reviewed. The focus is on the elementary dynamics of atoms and molecules on the femtosecond (10−15 second) time scale. Current research is discussed, and opportunities for the future are explored.
The hypothalamic-pituitary-adrenocortical system (1997)

The hypothalamic-pituitary-adrenal (HPA) axis has undoubtedly received more psychobiologic scrutiny than any other endocrine axis. Historically, one rationale for the intensive study of adrenocortical function in patients with primary psychiatric disorders was the observation that patients with primary endocrine disorders such as Addison's disease or Cushing's syndrome exhibited a higher than expected psychiatric morbidity. The most intensive scrutiny of the HPA axis has been conducted in patients with major depression. Cushing's syndrome, due to prolonged exposure to excessive Cortisol or other related glucocorticoids, is accompanied by psychiatric symptoms of anxiety and/or depression that generally remit with diminution of abnormal glucocorticoid concentrations. Despite the higher incidence of depression in women than men and the purportedly increased occurrence of depression during and after menopause, the hypothalamic-pituitary-gonadal (HPG) axis has received relatively little scrutiny in patients with mood disorders.
Study on Hydrogen Combustors with Two-Staged Combustion Method for Micro Gas Turbines (Combustion Characteristics of Coaxial Type Injectors) (2007)

With the goal of developing advanced hydrogen combustors for micro gas turbines with low NOx emission at high temperatures up to Tit=1700°C, single coaxial injectors with two-staged (RQL; rich-quench-lean) combustion method were built, based on the excellent combustion features of hydrogen. The injector consisted of an inner pipe issuing rich premixed gases, and an outer concentric annular hole injecting secondary air at high velocity. The combustion characteristics of small test combustors, which had the injector and a combustion tube of 30 mm diameter, were examined at room temperature and atmospheric pressure, concerning NOx emissions, temperature distributions, combustion efficiencies, total pressure losses and flame stability limits. The optimum equivalence ratio of the rich premixed inner flame was confirmed to be about 2.0 for the viewpoint of decreasing NOx emission and total pressure loss. The NOx concentrations were reduced by decreasing the area of the coaxial air hole, and were in inverse proportion to the ratio of the momentum of the coaxial air to the premixed gas. For the injector with the smallest area of air hole, having pressure loss of below 4%, NOx emission levels were low enough, and high combustion efficiencies over 99.95% were attained in the range from 0.3 to 0.6 of overall equivalence ratio, since mixing in the second stage was so rapid. It was confirmed that this type of injector was suitable for two-staged RQL combustion.
A real-time approach to stereopsis and lane-finding (2002)

Reports new results we have obtained in applying stereo vision algorithms to the problem of autonomous vehicle navigation on highways. The project consists of two parts: lane extraction and obstacle detection. Our lane extraction system is based on a parameterized model for the appearance of the lanes in the images. This model captures the position, orientation and width of the lane as well as the height and inclination of the stereo rig with respect to the road. A robust lane recognition procedure is employed to recover the position of the vehicle within the lane. This scheme is able to recover and track the lane markers in real time (20 Hz) even in the presence of a significant number of spurious lane features. We have developed a new real time stereo system (20 Hz) that has been optimized for use in a highway navigation system. The algorithm first extracts vertical line features from a subset of the scan lines in the left and right images. Correspondences are made between line features in the left and right images by a region-based correlation scheme. The results of this process can then be passed to the grouping and tracking process. The paper also describes the implementation of these algorithms on our network of TMS320C40 DSPs. This computational architecture allows us to handle the demanding computational and I/O requirements of these applications. These algorithms have been tested on video data obtained from a test vehicle that was driven in typical highway traffic. Results from these experiments are presented.
On linearly polarized electromagnetic waves of arbitrary form (1954)

ABSTRACT Two simple laws connecting the amplitude and phase functions of a monochromatic electromagnetic wave of arbitrary form are derived, holding in the case when one of the field vectors is linearly polarized. The first is a generalized Fermat's principle which enables determination of the phase when the amplitude is known; the second expresses the propagation of the (vector) amplitude along the curves orthogonal to the co-phasal surfaces. Some other general properties of linearly polarized fields are also discussed, and illustrative examples are given.
<title>Integrating multimedia streams into a distributed computing system</title> (1996)

Continuous media, such as audio and video, are quickly becoming an integral part of distributed computing environments. A shortcoming of such environments is their lack of support for continuous flows of information. What is missing is the notion of an on-going communication activity with an associated quality of service. This paper describes a model for integrating multimedia flows into a distributed computing system. The model permits explicit bindings to be established between type-checked stream interfaces. The stream binding is represented in the computational model as a first-class object which encapsulates configuration rules and QoS attributes. An operational interface supplied by the binding object allows other objects within the system to manage the binding, to renegotiate QoS parameters, to control the flows across the binding, and to register interest in stream events such as flow reports and communication errors. The in-band stream interface is an abstract C++ wrapper around transport mechanisms that include intra-host IPC and network transport protocols such as TCP and XTP. A prototype implementation of this model is described using the Common Object Request Broker Architecture. The implementation environment comprises a local area ATM network with directly attached multimedia peripherals and general purpose workstations.
Mononuclear Metallacyclic Silver(I) Complexes of Third Generation Bis(1-pyrazolyl)methane Ligands (2009)

The third-generation bis(1-pyrazolyl)methane ligands p-C(6)H(4)[CH(2)OCH(2)CH(pz)(2)](2) (L(p), pz = pyrazolyl ring) and m-C(6)H(4)[CH(2)OCH(2)CH(pz)(2)](2) (L(m)) have been synthesized by the reaction of (pz)(2)CHCH(2)OH with NaH followed by alpha,alpha'-dibromo-p-xylene or alpha,alpha'-dibromo-m-xylene. The reaction of L(p) with AgBF(4), AgPF(6), and AgO(3)SCF(3) yields the new compounds {Ag[p-C(6)H(4)(CH(2)OCH(2)CH(pz)(2))(2)]}BF(4), {Ag[p-C(6)H(4)(CH(2)OCH(2)CH(pz)(2))(2)]}PF(6), and {Ag[p-C(6)H(4)(CH(2)OCH(2)CH(pz)(2))(2)]}O(3)SCF(3), respectively. A similar reaction of L(m) with AgBF(4) and AgPF(6) yields {Ag[m-C(6)H(4)(CH(2)OCH(2)CH(pz)(2))(2)]}BF(4) and {Ag[m-C(6)H(4)(CH(2)OCH(2)CH(pz)(2))(2)]}PF(6). These compounds were crystallized from both acetone and acetonitrile to yield nine crystalline forms of (LAg)(+) that differ in counterion and solvent of crystallization. In all complexes, the four pyrazolyl rings of the ligand chelate a single silver(I) cation in a distorted tetrahedral environment to form mononuclear metallacycles. This arrangement has not previously been observed with the analogous ligands based on tris(1-pyrazolyl)methane units and is unique because of the ring sizes (16-member rings in L(m) and 17-member rings in L(p)). The dominant feature in all of these solid state structures, regardless of solvent or anion, is this cationic metallacyclic architecture, which does not readily lend itself to strong supramolecular organization.
(Invited) Top-Gate Effects in Dual-Gate Amorphous InGaZnO<sub>4</sub> Thin-Film Transistors (2013)

We discuss the dependence of bottom-gate transfer characteristics (Vbg-Id) on top-gate voltage (Vtg), which we call "top-gate effects", using a-IGZO TFTs having a dual-gate structure. We consider the top-gate effects to be a measure of how a-IGZO TFT characteristics are sensitive to charge generation on TFTs. We compare the top-gate effects in a-IGZO TFTs and conventional channel-etched a-Si:H TFTs. We found that the positive top-gate effect in a-IGZO TFTs varied depending on top-channel properties, while the negative top-gate effect had a similar impact on Vbg-Id characteristics irrespective of top-channel properties. We also found that a-IGZO TFTs had more significant top-gate effects than conventional a-Si:H TFTs.
Use of a laser-induced fluorescence thermal imaging system for film cooling heat transfer measurement (2018)

This paper describes a novel approach based on fluorescence imaging of thermographic phosphor that enables the simultaneous determination of both local film effectiveness and local heat transfer on a film-cooled surface. The film cooling model demonstrated consists of a single row of three discrete holes on a flat plate. The transient temperature measurement relies on the temperature-sensitive fluorescent properties of europium-doped lanthanum oxysulfide (La{sub 2}O{sub 2}S:EU{sup 3+}) thermographic phosphor. A series of full-field surface temperatures, mainstream temperatures, and coolant film temperatures were acquired during the heating of a test surface. These temperatures are used to calculate the heat transfer coefficients and the film effectiveness simultaneously. Because of the superior spatial resolution capability for the heat transfer data reduced from these temperature frames, the laser-induced fluorescence (LIF) imaging system, the present study observes the detailed heat transfer characteristics over a film-protected surface. The trend of the results agrees with those obtained using other conventional thermal methods, as well as the liquid crystal imaging technique. One major advantage of this technique is the capability to record a large number of temperature frames over a given testing period. This offers multiple-sample consistency.
Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma (2015)

The close proximity of tumour-infiltrating T cells and B cells indicates a functional interaction between them that is linked to an enhanced local immune activation and contributes to better prognosis for patients with HCC.
Compliance with the ERAS Protocol and 3‐Year Survival After Laparoscopic Surgery for Non‐metastatic Colorectal Cancer (2019)

This study reports an association between adherence to the ERAS protocol and long-term survival after laparoscopic colorectal resection for non-metastatic cancer. Lower adherence to the protocol, independent from stage of cancer and postoperative complications, was an independent risk factors for poorer survival rates.
ChemInform Abstract: Photochemistry of Conjugated Nitrogen‐Carbonyl Systems. Part 3. (1986)

Abstract Die Photolyse der im Titel genannten Verbindung (I) in den angegebenen Lösungsmitteln führt zu den Addukten (II) und dem hydrierten Produkt (IIIa), das als Benzoat (IIIb) charakterisiert wird.
Inhomogeneity in local magnetic field due to susceptibility contrast (1999)

A method for computing local magnetic field for the case of small permeability or susceptibility contrast is described. The method is illustrated by using an example of a periodic array of cylinders which affords the simplest yet a representative case for visualizing the local fields. The cylinders represent material of one susceptibility such as solid grains in a rock matrix (or tissues in biological systems) and the space outside represents material of another susceptibility such as fluid which fills the pore space (or fluids outside tissues). We calculate the position dependent correction from the continuum to the local field inhomogeneity and go beyond the standard uniform field term. A simple (separate) illustration when the local field diverges is given.
Experimental Validation of a Reconfigurable GLONASS Sub-Sampling Receiver (2018)

Positioning and navigation with Global Navigation Satellite System (GNSS) like GPS, GLONASS, BEIDOU and GALILEO are more and more deployed in various telemetry applications. Achieving reliable and accurate results is the main objective especially while dealing with safety and critical applications, which need to be robust under challenging environments. Thus, the key solution for a better accuracy position is to integrate a new structure based on Radio Frequency sub-sampling (RFS) aiming to reduce the complexity by including only one RF front-end capable to collect multiple signals at the same time. This RFS architecture allows to digitize the received signals as close to the antenna as possible and has been found to be a useful tool in system design and prototyping. This paper presents an experimental assessment of the reconfigurable GNSS receiver based on GLONASS signals to demonstrate its operation and functionality. To carry out the measures, real-world satellite data are needed. A measurement companion on the GNSS receiver was conducted based on GLONASS signals in the G1 band which were generated by the Labsat2 equipment. To look for the visible satellites, the Parallel Code-Phase Search Acquisition algorithm was used (PCS). Acquisition results for GLONASS G1 are shown and the performance of the receiver is discussed.
Sound absorption height and width limits for polymer relaxations (1997)

An analysis was performed to relate the height and width of the peak in shear sound absorption per wavelength as a function of frequency for the glass transition of a polymer. For the single relaxation time model, the width is 1.14 decades only at small values of the ratio of relaxed to unrelaxed sound speed. For the larger values of sound-speed ratio observed in polymer glass transitions, the width increases as the height increases. For the Havriliak–Negami model, the width increases as the height decreases in a manner similar to that for the complex modulus, though in this case there is a cutoff below the absolute maximum. The curve can be described by the relation that height times width is 1.5 decades of frequency. These predictions are in good agreement with experimental data for 21 polyurethanes.