gebhart/patrepeval huggingface dataset:
Contractile economy and aerobic recovery metabolism in skeletal muscle adapted to creatine depletion (1994)

Mice were treated for 7-12 wk with the creatine analogue beta-guanidinopropionic acid (beta-GPA). Treatment reduced total creatine to approximately 5% of control values in soleus (SOL) and extensor digitorum longus (EDL) muscles. In both muscles from treated mice, phosphorylated beta-GPA accumulated and resting [ATP] decreased by approximately 50%. Relative to controls, cytochrome oxidase and citrate synthase activities increased significantly in EDL from treated mice, but not in SOL; creatine kinase activity decreased significantly in SOL, but not in EDL. Measurements of poststimulation energy metabolism show that the energy cost to maintain tension in SOL and EDL from treated mice was approximately 50% of that in control muscle. Relative to controls, first-order rate constants of poststimulation O2 demand were 2- and 3.6-fold greater in SOL and EDL, respectively, from treated mice. Increased economy of SOL and EDL from treated mice is consistent with previously reported changes in myosin isoenzymes. Increases in rate constants of O2 utilization in creatine-depleted muscle are inconsistent with the hypothesis that cytoplasmic or mitochondrial creatine kinase is rate limiting for cellular respiration.
Basazol Black 05L: A New Acid Resistant Metachromatic Stain for Normal and Abnormal Megakaryocytes (1996)

Bone marrow smears fixed in formalin-95% ethyl alcohol- glacial acetic acid (FAA), stained with a paper dye known as basic black 05L, exposed briefly to 1 N hydrochloric acid, and mounted with cyanoacrylate adhesive displayed a bright and distinctive violaceous cytoplasmic color in megakaryocytes. Except for mast cell granules that stained violet, all other hematopoietic cells in normal and abnormal marrow specimens stained yellow to yellow orange. Normal and abnormal megakaryocytes, such as unusually large megakaryocytes in essential thrombocythemia and small megakaryocytes in myelodysplastic disorders, displayed this acid resistant cytoplasmic metachromasia. The stain is inexpensive, easy to use, and may prove usefu1 for identification of atypical and small megakaryocytes in myeloproliferative and myelodysplastic disorders. (The J Histotechnol 19:317–320, 1996)
The First 12 Snorre Field Wells: Accelerating the Learning Process (1994)

Abstract This paper discusses the experience gained by Saga Petroleum during the drilling and completion of the first 12 wells at the Snorre Field as well as the systems developed to help maximize the learning curve. Included in the paper are specific examples of how the drilling and completion times at Snorre have been reduced.
Rhinovirus Infections in Hematopoietic Stem Cell Transplant Recipients with Pneumonia (2003)

Little is known about the impact of human rhinovirus (HRV) and coronavirus infections in hematopoietic stem cell transplant (HSCT) recipients. We tested bronchoalveolar lavage (BAL) samples obtained from HSCT recipients with acute pulmonary infiltrates for HRV (n=122) and coronavirus (n=46) by reverse-transcriptase polymerase chain reaction. HRV RNA was detected in 6 (8%) of 77 patients, and coronavirus RNA was detected in 0 of 46 of BAL samples from HSCT recipients. The fatality rate in HRV-infected patients was high (83%), but all patients had significant coinfections, and the overall mortality rate was not different from that of patients who were negative for HRV in BAL samples. These results suggest that HRV may be a cause of lower respiratory tract infections in HSCT recipients and that its detection in BAL samples is associated with frequent copathogens. Whether the poor prognosis is due to HRV or the copathogen is not clear.
On Non-Preemptive VM Scheduling in the Cloud (2017)

We study the problem of scheduling VMs (Virtual Machines) in a distributed server platform, motivated by cloud computing applications. The VMs arrive dynamically over time to the system, and require a certain amount of resources (e.g. memory, CPU, etc) for the duration of their service. To avoid costly preemptions, we consider non-preemptive scheduling: Each VM has to be assigned to a server which has enough residual capacity to accommodate it, and once a VM is assigned to a server, its service cannot be disrupted (preempted). Prior approaches to this problem either have high complexity, require synchronization among the servers, or yield queue sizes/delays which are excessively large. We propose a non-preemptive scheduling algorithm that resolves these issues. In general, given an approximation algorithm to Knapsack with approximation ratio r , our scheduling algorithm can provide rβ fraction of the throughput region for β < r . In the special case of a greedy approximation algorithm to Knapsack, we further show that this condition can be relaxed to β<1 . The parameters β and r can be tuned to provide a trade-off between achievable throughput, delay, and computational complexity of the scheduling algorithm. Finally extensive simulation results using both synthetic and real traffic traces are presented to verify the performance of our algorithm.
Malaria and pregnancy: evaluation of the strategies in malaria control during the antenatal clinics in the South of Cameroon (2005)

Introduction: Les femmes enceintes constituent avec les enfants de moins de 5 ans les populations les plus vulnérables face au paludisme et les CPN constituent un moment privilégié pour leur délivrer une information préventive. L’objectif de notre étude était d’étudier, à partir d’une enquête rétrospective, les connaissances sur le paludisme des femmes ayant suivies une consultation prénatale et d’évaluer leurs satisfactions et leurs attentes vis-à-vis des services de santé.Methodes: Au cours du 1er semestre 2003 nous avons réalisé une étude auprès des professionnels de santé et de 196 femmes ayant accouchées depuis moins de six mois dans une plantation du Sud Cameroun (Hévécam). Les données ont été recueillies auprès des femmes par questionnaires et complétées par l’analyse de leur carnet de santé. L’étude s’est appuyée également sur des entretiens auprès des femmes et des professionnels de santé et les femmes et une observation des relations de soins à l’hôpital et dans les dispensaires. Cette étude a été réalisée dans le cadre du projet PAL+ « Traiter et/ouPrévenir. Mères, enfants et soignants face au paludisme ».Resultats: L’examen des carnets de santé montre que 53 % des femmes ont bénéficié de 3 CPN, que 2/3 d’entre-elles ont utilisé une prophylaxie antipaludique adaptée et que 40 % ont eu un accès palustre durant la grossesse. Nous avons pu également évaluer les pratiques professionnelles à travers le récit de l’expérience de femmes du processus de la CPN. 47 % des femmes disent avoir reçu des informations sur les traitements prescrits et en ont effectivement une bonne connaissance. Néanmoins, on relève une insatisfaction des femmes vis-à-vis des professionnels de santé et de la qualité des soins délivrés Les résultats font également ressortir différentes contraintes matérielles et culturelles qui pèsent sur l’efficacité de la CPN : rôle économique du mari dans la décision de santé, suivi de la grossesse plus faible chez les primipares et les femmes jeunes, réticences des femmesvis-à-vis des antipaludiques lors de la grossesse bien que 85 % d’entre-elles déclarent avoir eu une bonne observance qu’il conviendra de discuter notamment au regard des pratiques d’automédication traditionnelle également mentionnéesInterpretation: Pour une meilleure compréhension des comportements des femmes enceintes les messages informatifs qui leur sont destinés et qui constituent dessupports de prévention doivent tenir compte des phénomènes de ré-appropriation et de ré-interpréation.
ChemInform Abstract: New Diterpenoids from the Alga Dictyota dichotoma. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of constant strain rate, composed of varying amplitude and frequency, of early loading on peri‐implant bone (re)modelling (2007)

Early controlled stimulation of peri-implant bone is related to amplitude/frequency and not to strain rate as such, considering a constant stimulation time. An increase of bone mass around early-loaded implants was shown. This cortical bone model is most sensitive to low-frequency/high-amplitude stimulation.
Synthesis of Zeolite from Coal Fly Ash: Its Application as Water Sorbent (2010)

Coal fly ash (CFA) was used as raw material for zeolite synthesis using the fusion method. In detail, it was mixed with NaOH (with ratio of 2.25) and treated under various temperatures. The synthesized zeolite was characterized using various techniques i.e. X-rayfluorescence (XRF), X-ray diffraction (XRD), and BET surface area analysis. It was found that the surface area of the synthesized zeolite was in the range of 49-69 m 2 /g depending on the preparation conditions, compared to the surface area of CFA about 17 m 2 /g. In addition, according to the XRD result, it was proven that the form of zeolite was Sodium Aluminum Silicate Hydrate (1.08Na
Gravity prospecting for reefs; effects of sedimentation and differential compaction (1961)

Abstract The classical questions are: "Do reefs create recognizable gravity anomalies?" "If and when they do, then what causes these anomalies?" To find the answers to these questions, first a study of the case histories was made. It indicated that deeply buried, "isolated," organic reefs frequently create recognizable but "mysterious" gravity anomalies, and that there is no evident direct relation between the reef mass and the gravity anomaly. To find out the cause of these anomalies, the field of investigation proved to be so large that this paper could be entitled "a tentative density analysis of the sedimentary subsurface." The reef mechanism and the depositional processes are such that there is a concentration of sand in the over-reef section. Densities in clay and sand mixtures were investigated in terms of composition and depth of burial. The sand concentration alone is capable of creating shallow positive and deep negative density contrasts sufficient to account for the major part of the gravity anomaly. The gravity effect of a hypothetical reef was calculated. The result was very much like those actually observed. The gravity anomaly depends mainly on what has happened after the reef was buried, and not on the contrast at the reef level.
Acute Anterior Uveitis: A Model for HLA-B27 Associated Diseases (1983)

Acute Anterior Uveitis: A Model for HLA-B27 Associated Diseases Get access Laurine F. White, Laurine F. White Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard J. McCoy, Richard J. McCoy Search for other works by this author on: Oxford Academic PubMed Google Scholar Brian Tait, Brian Tait Search for other works by this author on: Oxford Academic PubMed Google Scholar Roland Ebringer Roland Ebringer Search for other works by this author on: Oxford Academic PubMed Google Scholar Rheumatology, Volume XXII, Issue suppl_2, January 1983, Pages 148–150, https://doi.org/10.1093/rheumatology/XXII.suppl_2.148 Published: 01 January 1983
Acid stability of several benzylic protecting groups used in solid-phase peptide synthesis. Rearrangement of O-benzyltyrosine to 3-benzyltyrosine (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcid stability of several benzylic protecting groups used in solid-phase peptide synthesis. Rearrangement of O-benzyltyrosine to 3-benzyltyrosineBruce W. Erickson and R. B. MerrifieldCite this: J. Am. Chem. Soc. 1973, 95, 11, 3750–3756Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/ja00792a046https://doi.org/10.1021/ja00792a046research-articleACS PublicationsRequest reuse permissionsArticle Views1623Altmetric-Citations143LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prolonged Incubation and Extensive Subculturing Do Not Increase Recovery of Clinically Significant Microorganisms from Standard Automated Blood Cultures (2005)

An extensive blood culture protocol, including prolonged incubation of cultures, for 215 patients believed to have had endocarditis yielded only 3 clinically relevant results. Twenty-four Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, and Kingella (i.e., HACEK) organisms were recovered from standard 5-day blood cultures during the same time period. Specialized methods and not extended incubation times are recommended for recovery of fastidious agents of septicemia.
Kinect V2 implementation and testing of the reaching performance scale for motor evaluation of patients with neurological impairment (2018)

Automated procedures for neurological patients' motor evaluation may take advantage of the coupling between clinical scales and motion tracking devices to provide affordable, quantified and reliable assessment to be used in clinics, in surgeries and domestic environment. In this study, 20 post-stroke patients performed frontal reaching movements with their more affected limb, and a physician administered the Reaching Performance Scale (RPS) to assess motor functionality. At the same time, patients' kinematics were recorded with the Kinect V2 sensor. An automated algorithm was developed to compute the RPS based on Kinect V2 tracking data, and visual and Kinect V2 RPS scores were compared. Results showed very high statistical correlation between the automated procedure and the visual administration (Pearson Correlation Coefficient: R = 0.90, p < 0.001). While the number of patients is limited, the automated RPS seems to be successfully applicable to different levels of impairment, from mild to severe.
The removal of extracellular calcium: a novel mechanism underlying the recruitment of <i>N</i>‐methyl‐<scp>d</scp>‐aspartate (NMDA) receptors in neurotoxicity (2005)

The involvement of NMDA-type glutamate receptor in neuronal injury established in experimental stroke and neurotrauma models has been recently challenged by failures in treatment of stroke/neurotrauma patients with NMDA receptor antagonists. NMDA receptor activity is known to be essential for mediating a multitude of physiological functions. However, how NMDA receptors are recruited to cause neuronal injury remains unclear. Here we report that the time period during which initial NMDA receptor up-regulation occurs is critical for the recruitment of NMDA receptors causing neuronal injury during extracellular calcium (Ca2+) reperfusion in cultured hippocampal neurons, and represents the key period for neuronal protection by NMDA receptor antagonists. Furthermore, we identified that via intracellular sodium (Na+), extracellular Ca2+ depletion induces the up-regulation of NMDA receptor gating. Taken together, our study provides direct experimental evidence suggesting that determination of when and how NMDA receptors are recruited to cause neurotoxicity is essential for guiding treatment via antagonism of NMDA receptor functions.
Service-Oriented Development of Fault Tolerant Communicating Systems (2010)

Telecommunication systems must have a high degree of availability, that is, a high probability of correct and timely provision of requested services. To achieve this, correctness of software for such systems should be ensured. Application of formal methods helps increase confidence in building correct software. However, to be used in practice, formal methods should be well integrated into existing development process. In this paper, the authors propose a formal model-driven approach to development of communicating systems. The authors formalize and extend the Lyra approach—a top-down service-oriented method for development of communicating systems. Lyra is based on transformation and decomposition of models expressed in UML2. The authors formalize Lyra in the B Method by proposing a set of formal specification and refinement patterns reflecting the essential models and transformations of the Lyra phases. Moreover, this paper extends Lyra to integrate reasoning about fault tolerance in the entire development flow.
The DPYSL2 gene connects mTOR and schizophrenia (2016)

We previously reported a schizophrenia-associated polymorphic CT di-nucleotide repeat (DNR) at the 5'-untranslated repeat (UTR) of DPYSL2, which responds to mammalian target of Rapamycin (mTOR) signaling with allelic differences in reporter assays. Now using microarray analysis, we show that the DNR alleles interact differentially with specific proteins, including the mTOR-related protein HuD/ELAVL4. We confirm the differential binding to HuD and other known mTOR effectors by electrophoretic mobility shift assays. We edit HEK293 cells by CRISPR/Cas9 to carry the schizophrenia risk variant (13DNR) and observe a significant reduction of the corresponding CRMP2 isoform. These edited cells confirm the response to mTOR inhibitors and show a twofold shortening of the cellular projections. Transcriptome analysis of these modified cells by RNA-seq shows changes in 12.7% of expressed transcripts at a false discovery rate of 0.05. These transcripts are enriched in immunity-related genes, overlap significantly with those modified by the schizophrenia-associated gene, ZNF804A, and have a reverse expression signature from that seen with antipsychotic drugs. Our results support the functional importance of the DPYSL2 DNR and a role for mTOR signaling in schizophrenia.
CD14 <sup>+</sup> CD163 <sup>+</sup> IL-10 <sup>+</sup> monocytes/macrophages: Pro-angiogenic and non pro-inflammatory isolation, enrichment and long-term secretion profile (2010)

The establishment of a stable endothelial layer on a biomaterial suture is a well known strategy to achieve hemocompatibility. The endothelialisation is supported by factors as e.g. vascular endothelial growth factor (VEGF), which can be secreted by monocytes/macrophages (mo/mΦ) in an angiogenic milieu. In order to avoid detrimental inflammation triggered by these mo/mΦ, we established a protocol for the generation of alternatively activated macrophages and studied their response towards VEGF-A165. We could generate sufficient amounts of these CD14+ CD163+ IL-10+ mo/mΦ from buffy coats(8.6 ± 4.7 × 105 cells/mlbuffy coat). Furthermore, we achieved a VEGF-A165 secretion in the nanogram range. The VEGF-A165 secretion increased 2.1-fold within 14 days from 7.6 ± 2.2 to 16.1 ± 2.5ng/ml when the cells were grown with a VEGF-A165 supplemented (10ng/ml) cell culture medium. Within this time period the secretion levels of other pro-angiogenic growth factors (bFGF, PDGF-BB) and immunomodulatory cytokines (IL-10, IL-12, IL-1ra, TNFα, IFNγ) reached only the picogram range. These results suggest that angiogenically stimulated CD14+ CD163+ IL-10+ mo/mΦ might be useful as a cellular cytokine delivery system supporting endothelialisation of biomaterials without inducing pro-inflammatory effects.
Transcriptional and post-transcriptional profile of human chromosome 21 (2009)

Recent studies have demonstrated extensive transcriptional activity across the human genome, a substantial fraction of which is not associated with any functional annotation. However, very little is known regarding the post-transcriptional processes that operate within the different classes of RNA molecules. To characterize the post-transcriptional properties of expressed sequences from human chromosome 21 (HSA21), we separated RNA molecules from three cell lines (GM06990, HeLa S3, and SK-N-AS) according to their ribosome content by sucrose gradient fractionation. Polyribosomal-associated RNA and total RNA were subsequently hybridized to genomic tiling arrays. We found that approximately 50% of the transcriptional signals were located outside of annotated exons and were considered as TARs (transcriptionally active regions). Although TARs were observed among polysome-associated RNAs, RT-PCR and RACE experiments revealed that approximately 40% were likely to represent nonspecific cross-hybridization artifacts. Bioinformatics discrimination of TARs according to conservation and sequence complexity allowed us to identify a set of high-confidence TARs. This set of TARs was significantly depleted in the polysomes, suggesting that it was not likely to be involved in translation. Analysis of polysome representation of RefSeq exons showed that at least 15% of RefSeq transcripts undergo significant post-transcriptional regulation in at least two of the three cell lines tested. Among the regulated transcripts, enrichment analysis revealed an over-representation of genes involved in Alzheimer's disease (AD), including APP and the BACE1 protease that cleaves APP to produce the pathogenic beta 42 peptide. We demonstrate that the combination of RNA fractionation and tiling arrays is a powerful method to assess the transcriptional and post-transcriptional properties of genomic regions.
Effects of glucocorticoids on hippocampal long‐term potentiation (1993)

The effects of chronic and acute corticosterone (CORT) administration were investigated on hippocampal long-term potentiation (LTP) in the dentate gyrus granule cell layer of the rat. Electrophysiological experiments were performed in vivo under urethane anesthesia. Chronic CORT treatment (40 mg/kg/day) over 21 days decreased LTP compared to vehicle controls, even when LTP was measured 48 hours after cessation of CORT treatment, when serum CORT levels had returned to baseline. A single injection of CORT also decreased LTP compared to vehicle controls, but only when CORT levels were high, since at 48 hours after a single acute CORT injection LTP was not depressed. The decrements in LTP were seen both for the slope of the excitatory postsynaptic potential and for the population spike. Yet CORT had no effects on posttetanic potentiation or neuronal excitability. These findings are consistent with previous reports showing a reduction in LTP in the CA1 field of animals exposed to stress or acute CORT administration.