gebhart/patrepeval huggingface dataset:
Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue (2012)

There is increasing evidence that proteins associated with lipid droplets (LDs) play a key role in the coordination of lipid storage and mobilization in adipocytes. The small GTPase, RAB18, has been recently identified as a novel component of the protein coat of LDs and proposed to play a role in both β-adrenergic stimulation of lipolysis and insulin-induced lipogenesis in 3T3-L1 adipocytes. In order to better understand the role of Rab18 in the regulation of lipid metabolism in adipocytes, we evaluated the effects of age, fat location, metabolic status, and hormonal milieu on Rab18 expression in rodent white adipose tissue (WAT). Rab18 mRNA was undetectable at postnatal day 15 (P15), but reached adult levels by P45, in both male and female rats. In adult rats, Rab18 immunolocalized around LDs, as well as within the cytoplasm of mature adipocytes. A weak Rab18 signal was also detected in the stromal-vascular fraction of WAT. In mice, fasting significantly increased, though with a distinct time-course pattern, Rab18 mRNA and protein levels in visceral and subcutaneous WAT. The expression of Rab18 was also increased in visceral and subcutaneous WAT of obese mice (diet-induced, ob/ob, and New Zealand obese mice) compared with lean controls. Rab18 expression in rats was unaltered by castration, adrenalectomy, or GH deficiency but was increased by hypophysectomy, as well as hypothyroidism. When viewed together, our results suggest the participation of Rab18 in the regulation of lipid processing in adipose tissue under both normal and pathological conditions.
A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942 (2012)

1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione (1) was obtained from the culture broth of a marine-derived fungus, Beauveria bassiana TPU942, isolated from a marine sponge collected at Iriomote Island in Okinawa, together with two known compounds, chrysazin (2) and globosuxanthone A (3). The structure of 1 was elucidated on the basis of its spectroscopic data (HREIMS, 1D and 2D NMR experiments including ¹H--¹H COSY, HMQC and HMBC spectra). Dibenz[b,e]oxepines are rare in nature, and only six natural products have been reported. Therefore, compound 1 is the seventh natural product in this class. Compounds 2 and 3 showed an antifungal activity against Candida albicans, and 3 inhibited the cell growth against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma). Compound 1 did not show an apparent activity in the same bioassays.
Micro-simulation de variantes d'aménagement pour San Sebastian (2003)

Le projet traite du remodelage de la structure urbaine du district d'Amara dans la ville de San Sebastian au pays basque espagnol. Amara -et en particulier la place Pio XII située au coeur du district- canalise toute la circulation de transit de la ville à laquelle vient s'ajouter la trafic induit par les centres d'intérêts locaux (bureaux, zones commerciales, tourisme, etc.).
Radiofrequency power calibration for magnetic resonance imaging using signal phase as indicator (1999)

A novel radiofrequency (rf) power calibration method for the purpose of nuclear magnetic resonance excitations based on monitoring signal phase rather than signal amplitude is described theoretically and is demonstrated experimentally. This unique method enables the determination of rf power required for any desired tip angle in clinical magnetic resonance imaging procedures with an accuracy of 1-5%, essentially independent of motion, flow, slice variations, and/or T1 and T2 variations. The advantages of the new method are discussed and are compared with currently common, amplitude-based calibration techniques.
HYDRAULIC AIR COMPRESSOR WITH GAS TURBINES (1981)

The hydraulic air compressor is an ancient device for compressing air by entraining it in a stream of water which passes through a deep stilling cavern before returning to the surface, leaving compressed air in the cavern. Its isothermal compression cycle is ideally suited for combination with a gas turbine. The net saving by combining a hydro site with a peaking gas turbine can be as high as 50% of the gas turbine capacity.
Water and Solute Transport in a Cultivated Silt Loam Soil: 1. Field Observations (2005)

Vadose zone flow and transport processes are known to be strongly affected by both soil structure and soil texture. We conducted a field experiment to explore the impact of heterogeneity in soil structure created by agricultural operations such as wheel traffic, plowing, and surface tillage on water and solute transport. The experiment was performed on a 4 by 2 m 2 field plot perpendicular to the path of a tractor that had pulled a harrow for seedbed preparation. The plot was irrigated with a rainfall simulator at a rate of 21 mm h −1 for 2 h and 20 min. An 850 mg L −1 bromide solution was subsequently applied at a rate of 26 mm h −1 for 2 h. Soil water contents and pressure heads during the experiment were monitored with time domain reflectometry (TDR) probes and tensiometers. The soil was sampled for resident bromide (Br − ) concentrations at the end of the experiment. Water and bromide fronts were found to be highly heterogeneous. The heterogeneity could be explained by the particular soil structural features created by the agricultural practices, in particular by the locations and sizes of compacted soil zones. Very little water and bromide had penetrated the large compacted zones under the wheel tracks. Bromide, TDR, and tensiometer measurements all indicated the presence of preferential flow of water and bromide along paths immediately bordering the wheel tracks. The compacted clods in the plow layer furthermore acted as low‐permeability barriers that diverted water and bromide flow around them. The highly heterogeneous plow layer between the wheel tracks produced a much higher solute dispersivity as compared to the compacted soil below the wheel tracks.
High dynamic range ultrasound imaging with real-time Filtered-Delay Multiply and sum beamforming (2017)

Most commercially available ultrasound imaging systems currently implement the delay and sum (DAS) beamforming. Alternative beamformers have been presented, offering higher performance at the expense of computational complexity, which has so far limited their actual implementation. In particular, the Filtered-Delay Multiply and Sum (F-DMAS) beamformer, which adds the computation of signed square roots, absolute values and multiplications to DAS, was recently shown to be effective in improving resolution, dynamic range and overall image quality (DOI: 10.1109/TMI.2014.2371235). In this work, we present the real-time implementation of the F-DMAS beamformer on the ULA-OP256 research system.
Physical Removal of Biofilm (2015)

Biofilms form plaque on teeth and contribute to slime and scale buildup that result in clogged pipes and drains. Clogged pipes display smaller diameters and exhibit a reduced ability for heat exchange and liquid flow. A company with such a problem could experience increases in energy consumption and operational costs. Also if not corrected on time, it may need to shut down for an extended period in order to replace the defective pipes. Therefore it is essential to clean pipes, drains, and water mains frequently, in order to protect them from scale and biofilm buildup. Physical cleaning methods exist for effectively removing biofilms. Some are presented and described in this chapter. They include flushing, swabbing, air scouring, pigging, and ultrasonic scaling (used to remove plaque on teeth).
Mitigating Challenges in Resolving 7" Liner Leak-Case Study (2013)

Abstract An evaluation process was conducted in assessing various solutions towards remedial action to a 7" liner with an identified leak in a water injector well. The leak to the 7" liner was identified through pressure testing of the well. A comprehensive investigation and analysis was performed to identify the liner condition, exact leak location and the extent of the leak. It was accomplished by analyzing all previous activities performed during the life of the well and through running special pressure testing as well as logging the well with ultrasonic and physical logs. The problem identification and proposed solutions were focused on curing the leak and bringing the well back on injection with the least operational risk and highest possibility of success. Corrosion and cement bond logs were ran and showed a better picture in regards to the extent of the corroded section and the quality of cement behind it. A caliber log was also run in the open hole which showed a washed out area near the 7" liner shoe. Several solutions that could repair the 7" liner leak were assessed including: i) cement squeeze in the leak zone, ii) setting an off bottom 4.5" liner and iii) using a 5.5" expandable liner. The evaluation process included eachsolution's impact on the future injectivity of the well, the effectiveness of each option, operational challenges and associated risks. Moreover, nodal analysis was performed to evaluate possible reduction of the injection rate associated with each solution. The final decision to repair the leak was to run an expandable liner and it was based on its advantages and deployment challenges. Lessons learned from this operation included the methods used to identify and assess the damage of the casing leak. Proper preparation and cleanout of the corroded section and the operation procedures performed to expand the liner are summarized in this paper.
Effect of class I MHC binding peptides on recognition by natural killer cells (1992)

NK cells can recognize and destroy a broad range of cells, including many tumor cells and virally infected cells, yet spare most normal cells. Identification of the target structure recognized by these cells has proved elusive. An attractive hypothesis is that, unlike B cells and T cells that recognize a specific foreign marker, NK cells respond to the absence of a "self" marker. Class I MHC molecules have been implicated as the self markers whose absence can trigger lysis. We show here that normal cells are lysed on incubation with IL-2-activated NK cells if peptides that can bind to the class I MHC molecules of the normal cells are also included in the assay, and speculate that this binding is somehow removing a self marker that normally protects a cell from lysis. NK cells were derived from splenocytes of young (5 to 8 wk old) athymic nude BALB/c (H-2d) or nude C57Bl/6 (H-2b) mice incubated with 1000 U/ml rIL-2, and target cells were derived from splenocytes of normal BALB/c or C57Bl/6 mice incubated with Con A. Peptides were from xenogeneic, viral, self, and mutated self protein sequences and included sequences specific for Kd, Kb, Db, and Ld. All peptides increased lysability of those targets to which they could bind.
Resistance Determinants and Clonal Diversity in Group A Streptococci Collected during a Period of Increasing Macrolide Resistance (2002)

Susceptibility to macrolides and lincosamides was investigated with 299 consecutive nonduplicate Streptococcus pyogenes clinical isolates collected over a 6-year period (1992 to 1997) from an area of central Italy. During this period, macrolide resistance rates steadily increased (from 9% in 1992 to 53% in 1997; P < 0.001). The increase was caused by isolates with a macrolide-lincosamide-streptogramin B resistance phenotype, carrying mostly erm(B) but also erm(TR) genes, that were not detected in the first 2 years and were detected with increasing prevalence (8, 5, 26, and 37%, respectively) during the following 4 years. During the same period, the prevalence of isolates with a macrolide resistance phenotype, carrying mef(A) determinants, did not vary significantly; on average it was 13%, with modest rate fluctuations in different years and no definite trend. Molecular typing revealed a remarkable clonal diversity among susceptible and resistant isolates and a notable heterogeneity of the genetic environment of the resistance genes. The analysis of clonal diversity in relation with resistance phenotypes and genotypes revealed that increased macrolide resistance rates were due to a complex interplay of different mechanisms, with a relevant contribution played by an "epidemic" spread of genetic elements carrying the erm(B) gene among the circulating streptococcal population.
Hormonal control of [14C]glucose synthesis from [U-14C]dihydroxyacetone and glycerol in isolated rat hepatocytes (1976)

The hormonal control of [14C]glucose synthesis from [U-14C-A1dihydroxyacetone was studied in hepatocytes from fed and starved rats. In cells from fed rats, glucagon lowered the concentration of substrate giving half-half-maximal rates of incorporation while it had little or no effect on the maximal rate. Inhibitors of gluconeogenesis from pyruvate had no effect on the ability of the hormone to stimulate the synthesis of [14C]glucose from dihydroxyacetone. The concentrations of glucagon and epinephrine giving half-maximal stimulation from dihydroxacetone were 0.3 to 0.4 mM and 0.3 to 0.5 muM, respectively. The meaximal catecholamine stimulation was much less than the maximal stimulation by glucagon and was mediated largely by the alpha receptor. Insulin had no effect on the basal rate of [14C]clucose synthesis but inhibited the effect of submaximal concentration of glucagon or of any concentration of catecholamine. Glucagon had no effect on the uptake of dihydroxyacetone but suppressed its conversion to lactate and pyruvate. This suppression accounted for most of the increase in glucose synthesis. In cells from gasted rats, where lactate production is greatly reduced and the rate of glucose synthesis is elevated, glucagon did not stimulate gluconeogenesis from dihydroxyacetone. Findings with glycerol as substrate were similar to those with dihyroxyacetone. Ethanol also stimulated glucose production from dihydroxyacetone while reducing proportionately the production of lactate. Ethanol is known to generate reducing equivalents fro clyceraldehyde-3-phosphate dehydrogenase and presumably thereby inhibits carbon flux to lactate at this site. Its effect was additive with that of glucagon. Estimates of the steady state levels of intermediary metabolites and flux rates suggested that glucagon activated conversion of fructose diphosphate to fructose 6-phosphate and suppressed conversion of phosphoenolpyruvate to pyruvate. More direct evidence for an inhibition of pyruvate kinase was the observation that brief exposure of cells to glucagon caused up to 70% inhibition of the enzyme activity in homogenates of these cells. The inhibition was not seen when the enzyme was assayed with 20 muM fructose diphosphate. The effect of glucagon to lower fructose diphosphate levels in intact cells may promote the inhibition of pyruvate kinase. The inhibition of pyruvate kinase may reduce recycling in the pathway of gluconeogenesis from major physiological substrates and probably accounts fromsome but not all the stimulatory effect of glucagon.
On the evaluation of antenna quality factors (1969)

Compact expressions are given for the reactive energies and modal quality factors in the literature. The formulas do not involve spherical Bessel functions and are in terms of, at most, two polynomials having positive coefficients which are readily calculable. Curves are presented for the exact forms for a number of modal quality factors.
P‐135: Concept of e‐Tile and its Prototyping (2018)

“e‐Tile”, a novel concept for large area displays, is introduced. A typical e‐Tile configuration, in which 100 pixels are mounted on a 100 mm square board, is designed and prototyped. One promising application is the unobtrusive information board, which is far less annoying than the conventional vivid LED/LCD in public spaces.
The rebuilding and resuming of SD model of the eco-environment in the agriculture and animal husbandry interlock zone along the Great Wall. (2005)

The rebuilding of SD model and resuming of the ec o-environment in the agriculture and animal husbandry interlock zone along the Great Wall were establ ished by a system dynamic theory,and a simulating study for three typical manage ment patterns,a intensified management,steady development and traditional manage ment,in the region was made by the SD model.The results show that the intensifie d management pattern is the best approach to harness the eco-e nvironment in the region,it can balance the development of agriculture,forestry and animal husband ry,reduce the soil erosion by 76.1%,return a good circle of eco-environment in the region.
Supervisory Control With Progressive Events (2014)

This paper investigates some limitations of the nonblocking property when used for supervisor synthesis in discrete event systems. It is shown that there are cases where synthesis with the nonblocking property gives undesired results. To address such cases, the paper introduces progressive events as a means to specify more precisely how a synthesised supervisor should complete its tasks. The nonblocking property is modified to take progressive events into account, and appropriate methods for verification and synthesis are proposed.
A Method of Annotation Extraction from Paper Documents Using Alignment Based on Local Arrangements of Feature Points (2007)

Annotations on paper documents include important information. We can exploit the information by extracting and analyzing annotations. In this paper, we propose a method of annotation extraction from paper documents. Unlike previous methods which limit colors or types of annotations to be extracted, the proposed method attempts to extract annotations by comparing a document image of an annotated document with its original document image for removing the limitations. The proposed method is characterized by fast matching and flexible subtraction of images both of which are essential to the annotation extraction by comparison. Experimental results have shown that color annotations can be extracted from color documents.
GST-pi expression correlates with oxidative stress and apoptosis in breast cancer (2004)

Glutathione S-transferase (GST) is known to play a key role in the detoxification and reduction of reactive oxygen species (ROS). Thus, we assessed GST activity and GST-pi expression in relation to oxidative stress and apoptosis in breast cancer. Tumor tissues from 32 breast cancer patients were evaluated for GST activity and thiobarbituric acid reactive substances (TBARS) that are by-products of oxidative stress. Four-micron sections of formalin-fixed, paraffin embedded tumors were stained immunohistochemically with anti-GST-pi. Apoptotic cells were detected by in situ end labeling of DNA fragments using a commercial kit. TBARS levels were significantly higher in breast cancers of older patients. GST-pi expression was up-regulated in breast cancers that exhibited higher oxidative stress and associated with higher GST activity. Apoptosis in GST-pi negative tumors was not correlated with GST activity, but GST-pi positive tumors within the same range of oxidative stress showed a reduction in apoptosis as well as an increased GST activity. This correlation was absent in GST-pi positive tumors experiencing higher oxidative stress. GST-pi expression may influence the level of GST activity and delay apoptosis in breast cancer. However, GST-pi expression in tumors with higher levels of oxidative stress may not be sufficient to abrogate the deleterious effects of ROS.
Biologic dosimetry of bone marrow: induction of micronuclei in reticulocytes after exposure to 32P and 90Y. (2001)

Micronuclei in peripheral blood reticulocytes can be used as a noninvasive biologic dosimeter for measuring absorbed dose rate and absorbed dose to bone marrow from incorporated radionuclides.
When modelling bridges electro-catalysis and heterogeneous catalysis: The case of the formic acid decomposition (2016)

International audience
The complex structure of polyhydroxybutyrate (PHB) granules: four orthologous and paralogous phasins occur in Ralstonia eutropha (2004)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Inkjet Printing of Multilayer Millimeter-Wave Yagi-Uda Antennas on Flexible Substrates (2015)

This letter presents two high-gain, multidirector Yagi-Uda antennas for use within the 24.5-GHz ISM band, realized through a multilayer, purely additive inkjet printing fabrication process on a flexible substrate. Multilayer material deposition is used to realize these 3-D antenna structures, including a fully printed 120- μm-thick dielectric substrate for microstrip-to-slotline feeding conversion. The antennas are fabricated, measured, and compared to simulated results showing good agreement and highlighting the reliable predictability of the printing process. An endfire realized gain of 8 dBi is achieved within the 24.5-GHz ISM band, presenting the highest-gain inkjet-printed antenna at this end of the millimeter-wave regime. The results of this work further demonstrate the feasibility of utilizing inkjet printing for low-cost, vertically integrated antenna structures for on-chip and on-package integration throughout the emerging field of high-frequency wireless electronics.
Interactions between docetaxel (Taxotere) and Plasmodium falciparum-infected erythrocytes. (1994)

Taxotere (docetaxel) inhibits Plasmodium falciparum erythrocytic development in vitro at nanomolar concentrations, both in chloroquine-sensitive (F32/Tanzania) and chloroquine-resistant (FcB1/Colombia, FcR3/Gambia) strains. The dose-response assays performed on asynchronous cultures during 42 hr showed clear biphasic curves with a plateau from 50 microM to 10 nM and a single sigmoid curve with a concentration inhibiting 50% of growth (IC50) of 3-6 nM observed after a 72-hr incubation. Addition of Taxotere to different stages of FcB1 revealed two types of targets: one type on ring/trophozoite-infected erythrocytes (RBCs), at the micromolar level, and another type on schizont-infected RBCs with Taxotere at micromolar concentrations inhibited the merozoite invasion of erythrocytes and parasite growth. These Taxotere-RBC interactions were stable, at least for 1 day. Pulse experiments of 5 hr with Taxotere efficiently inhibit parasite development regardless of the period of the parasite's erythrocytic life cycle. However, different cellular effects were obtained depending upon periods of drug incubations. The inhibition of P. falciparum development by Taxotere should provide additional strategies to block parasite development.