gebhart/patrepeval huggingface dataset:
Factors affecting the regional haemodynamic responses to glyceryl trinitrate and molsidomine in conscious rats (1991)

1. A series of experiments was performed in conscious, unrestrained, male, Long Evans rats, chronically instrumented for the measurement of regional haemodynamics. 2. Infusion of glyceryl trinitrate (GTN, 0.1 mg kg-1 min-1, i.v.) for 10 min elicited tachycardia, but no sustained change in mean arterial blood pressure. Renal haemodynamics were unaffected, but there were reductions in hindquarters flow and vascular conductance together with substantial increases in flow and conductance in the mesenteric vascular bed. 3. In the presence of captopril (2 mg kg-1 bolus, and 1 mg kg-1 h-1 infusion, i.v.) GTN elicited significant hypotension and increases in renal blood flow and vascular conductance, indicating that activation of the renin-angiotension system opposed the dilator effects of GTN in this vascular bed. However, the mesenteric and hindquarters haemodynamic effects of GTN were not affected by captopril. In contrast, in the presence of enalaprilat (2 mg kg-1 bolus, and 1 mg kg-1 h-1 infusion, i.v.) there was significant enhancement of the mesenteric, as well as renal, haemodynamic effects of GTN. Hence, these results provide no evidence for the sulphydryl groups in captopril exerting a specific effect to enhance the haemodynamic actions of GTN in our experimental protocols. 4. Administration of molsidomine alone (1 mg kg-1, i.v. bolus) elicited tachycardia and hypotension; there were no changes in mesenteric or hindquarters haemodynamics, but renal flow and vascular conductance fell. Thus, the hypotensive effect of molsidomine was probably due to a reduction in cardiac output, consequent upon venodilatation. 5. In the presence of captopril or enalaprilat, molsidomine evoked renal and mesenteric vasodilatations in association with hypotension, indicating that activation of the renin-angiotensin system contributed to the lack of vasodilator responses to administration of molsidomine alone. However, since the effects of enalaprilat were more marked than those of captopril (in spite of the dose of both drugs being supramaximal for inhibition of angiotensin-converting enzyme), other factors must have been involved. 6. In a separate experiment, pretreatment with the nitric oxide synthesis inhibitor, N0-nitro-L-arginine methyl ester (1 mg kg- 1 h-1, i.v.), enhanced the mesenteric vasodilator effect of molsidomine. Collectively, these results are consistent with in vitro data showing that endogenous nitric oxide can inhibit the vasodilator effects of nitric oxide derived from molsidomine, and that the sulphydryl groups of captopril can protect endogenous nitric oxide from inactivation by oxygen-derived free radicals, thereby enhancing the inhibitory effect of endogenous nitric oxide on the vasodilator responses to exogenous nitric oxide derived from molsidomine (or GTN).
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids (2021)

Ovarian cancer metastasizes into peritoneum through dissemination of transformed epithelia as multicellular spheroids. Harvested from the malignant ascites of patients, spheroids exhibit startling features of organization typical to homeostatic glandular tissues: lumen surrounded by smoothly contoured and adhered epithelia. Herein, we demonstrate that cells of specific ovarian cancer lines in suspension, aggregate into dysmorphic solid "moruloid" clusters that permit intercellular movement, cell penetration, and interspheroidal coalescence. Moruloid clusters subsequently mature into "blastuloid" spheroids with smooth contours, a temporally dynamic lumen and immotile cells. Blastuloid spheroids neither coalesce nor allow cell penetration. Ultrastructural examination reveals a basement membrane-like extracellular matrix coat on the surface of blastuloid, but not moruloid, spheroids. Quantitative proteomics reveals down-regulation in ECM protein Fibronectin-1 associated with the moruloid-blastuloid transition; immunocytochemistry also confirms the relocalization of basement membrane ECM proteins: collagen IV and laminin to the surface of blastuloid spheroids. Fibronectin depletion accelerates, and enzymatic basement membrane debridement impairs, lumen formation, respectively. The regulation by ECM dynamics of the morphogenesis of cancer spheroids potentially influences the progression of the disease.
Estimation of hydrologic properties of heterogeneous geologic media with an inverse method based on iterated function systems (1995)

The highly heterogeneous nature of most geologic media, coupled with the restricted view of the subsurface available through boreholes, makes it difficult to determine the spatial distribution of subsurface hydrologic properties. Without such a description one cannot predict how fluid flow or solute transport will occur through permeable geologic media, and these predictions are critically needed to address many important environmental problems, including toxic chemical spills, leaking underground storage tanks, and long-term radioactive waste isolation. A common concern of these problems is the possible existence of high-permeability pathways connecting the problem to the biosphere. An understanding of flow and transport behavior is also necessary to optimize energy extraction from petroleum or geothermal reservoirs, where identifying low-permeability barriers that compartmentalize reservoirs and hamper efficient resource utilization is a key problem. The present work describes the development and application of a new inverse method for determining the spatial distribution of hydrologic properties (permeability and specific storage) in heterogeneous geologic media, using pressure transients from interference well tests. The method employs fractal concepts to improve efficiency and reliability. It is applicable to any sort of heterogeneous geologic medium in which wells communicate with each other, whether it be porous, fractured, or a combination thereof. Application to field data from a shallow aquifer at Kesterson Reservoir agrees well with an independent analysis using traditional well-test analysis methods. Application to a series of interference tests conducted at the Gypsy Pilot Site produces a detailed picture of the subsurface, which compares favorably with cross-well seismic imaging studies. 53 refs.
Recruitment of the NCoA/SRC-1/p160 Family of Transcriptional Coactivators by the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Complex (2002)

The aryl hydrocarbon receptor complex heterodimeric transcription factor, comprising the basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) proteins, mediates the toxic effects of TCDD (2,3,7,8 tetrachlorodibenzo-p-dioxin). The molecular events underlying TCDD-inducible gene activation, beyond the activation of the AHRC, are poorly understood. The SRC-1/NCoA-1, NCoA-2/GRIP-1/TIF-2, and p/CIP/AIB/ACTR proteins have been shown to act as mediators of transcriptional activation. In this report, we demonstrate that SRC-1, NCoA-2, and p/CIP are capable of independently enhancing TCDD-dependent induction of a luciferase reporter gene by the AHR/ARNT dimer. Furthermore, injection of anti-SRC-1 or anti-p/CIP immunoglobulin G into mammalian cells abolishes the transcriptional activity of a TCDD-dependent reporter gene. We demonstrate by coimmunoprecipitation and by a reporter gene assay that SRC-1 and NCoA-2 but not p/CIP are capable of interacting with ARNT in vivo after transient transfection into mammalian cells, while AHR is capable of interacting with all three coactivators. We confirm the interactions of ARNT and AHR with SRC-1 with immunocytochemical techniques. Furthermore, SRC-1, NCoA-2, and p/CIP all associate with the CYP1A1 enhancer region in a TCDD-dependent fashion, as demonstrated by chromatin immunoprecipitation assays. We demonstrate by yeast two-hybrid, glutathione S-transferase pulldown, and mammalian reporter gene assays that ARNT requires its helix 2 domain but not its transactivation domain to interact with SRC-1. This indicates a novel mechanism of action for SRC-1. SRC-1 does not require its bHLH-PAS domain to interact with ARNT or AHR, but utilizes distinct domains proximal to its p300/CBP interaction domain. Taken together, these data support a role for the SRC family of transcriptional coactivators in TCDD-dependent gene regulation.
A fast approximate interprocedural analysis for speculative multithreading compilers (2003)

Speculative multithreading (SpMT) promises to be very effective for parallelizing non-numeric programs. Data dependences are perhaps the most important factor in the crucial step of deciding the thread boundaries, and SpMT compilers need to estimate data dependences as precisely as possible. Interprocedural points-to and side-effects information is essential to accurately determine data dependences. Determining this information has been an Achilles' heel in SpMT compilation. Existing interprocedural analyses are unsuitable for large programs, as they have high complexity or generate imprecise (very conservative) information that is not useful for aggressive speculative parallelization.This paper presents a novel interprocedural analysis scheme that is highly effective for use in SpMT compilers. It has running time and memory requirement almost linear in the number of procedures in the input program. The information it generates is comparable in accuracy with those generated by highly accurate context-sensitive interprocedural analyses, although it does not guarantee safe information (which is not a requirement for SpMT compilers any way). We implemented this interprocedural analysis in our SpMT compiler, and parallelized large non-numeric programs from the SPEC 2000 suite. Parallel execution of these threads in an SpMT simulator demonstrate good speedups for these non-numeric programs.
Investigation of the Role of Phenols in Oxidative Degradation of Coal-Derived Naphthas (1982)

The oxidative instability of coal liquids is a possible problem for the utilization of these alternate fuels. Past experience with both petroleum and coal-derived distillates indicates that heteroatomic species are intimately involved in such degradation. However, the exact nature of the chemistry is, in many cases, unclear. The goal of this work is to study the role of phenols in the chemistry of oxidative degradation of naphthas from a variety of current conversion processes. The effects of exposure to oxygen, metal surfaces, and metal salts have been investigated in order to identify the major routes leading to gum formation. Coal-derived naphthas were aged under 02 and N2 as received and in contact with copper or cuprous chloride at various temperatures. The rate of 02 consumption was measured manometrically, and compositional changes were monitored via infrared, nuclear magnetic resonance, and mass spectrometry. The observed rates of 02 consumption, catalytic effects, and compositional changes were analyzed to identify the major chemical reactions responsible for precipitate formation.
Birth weight effect in twin‐born lambs from mid‐pregnancy shearing is associated with changes in maternal IGF‐I concentration (2009)

Abstract A number of studies have shown an increase in the birth weight of lambs in response to mid pregnancy shearing. The present study sought to determine whether the birth weight effect of mid‐pregnancy shearing is mediated through changes in maternal insulin‐like growth factor‐I (IGF‐I) and insulin‐like growth factor binding protein‐I (IGFBP‐I) concentrations. Single‐ and twin‐bearing ewes from three genetically divergent IGF‐I lines were either left unshorn or shorn at a mean day 90 of pregnancy (P90). Maternal plasma concentrations of IGF‐I and IGFBP‐I were measured at P89, P108 and P136. Lamb liveweight at birth and weaning weremeasured, andplasmaconcentrations of IGF‐I determined at weaning. Shearing increased the birth weight of twin lambs by over 350 g ( P < 0.05) without having any effect on singleton birth weight. The increased birth weight of twin lambs born to shorn ewes was associated with a decline in maternal plasma IGF‐I concentration ( P < 0.05) from P108 toP136. Low IGF‐I line ewes had lower ( P < 0.001) plasma IGF‐I than high IGF‐I line ewes at each stage measured but higher plasma IGFBP‐I at P89 and P108. Birth weights were higher in lambs born to low IGF‐I line ewes than in those born to high IGF line ewes. These results suggest that the difference in birth weight between twin lambs from shorn and unshorn dams was mediated through a decline in maternal plasma IGF‐I concentrations in late pregnancy. In support of previous studies, there was an inverse relationship between IGF‐I selection line and lamb birth weight.
Contribution de l’impact écotoxicologique de la valorisation agricole des boues d’épuration urbaines (2002)

Actuellement, 60% de la quantité de boues de stations d'épuration urbaines sont valorisés en agriculture et les échéances réglementaires en matière d'assainissement urbain vont conduire à une augmentation prévisible des tonnages épandus. Le présent projet vise plusieurs objectifs. Tout d’abord, nous proposons de rechercher et de doser certains pesticides particulièrement utilisés en milieu urbain dans des boues provenant de plusieurs origines. Ceci permettra d’évaluer l'exposition à ces polluants après identification et analyse quantitative par spectrométrie de masse couplée à la chromatographie liquide. Dans un second temps, nous étudierons l'impact de l'épandage des boues sur l’écosystème sol. Nous prendrons en compte une modification du transfert des pesticides (qu’ils soient apportés par les boues ou déjà présents dans le sol) entre le sol et la plante, ainsi que des effets non-intentionnels sur les organismes du sol. Le potentiel de perturbateur endocrinien des percolats issus des mélanges sol/boue sera également évalué. En parallèle, nous proposons de développer un test fongique permettant le suivi de l'impact global des pesticides et autres polluants organiques sur l’écosystème sol.
<title>Global noise characteristics of a laser Doppler vibrometer part II: experiments using beam dynamics</title> (1996)

This paper discussed the presence of `laser noise' in velocity measurements taken with an SLDV system. In this paper, an experiment is presented to investigate the optimal operating range of velocities for the SLDV system. Additionally, an experiment investigating the effect of the use of a highly retroreflective surface treatment on `laser noise' is also presented. In order to determine the relative extent of the `laser noise' in these scans, a novel statistical value which quantifies the overall quality of the scan data is developed, presented, and exercised on experimental test data.
DUAL RESONANCE THEORY WITH NONLINEAR TRAJECTORIES. (1971)

A dual resonance model with nonlinear trajectories which includes the Veneziano model as a limiting case is discussed.Rules are given for constructing the N-point function in such a model, and an explicit expression for the N-point planar tree graph is derived.A conjectured rule for loop diagrams is also presented.Representations of four-point function satelliteterms which admit straightforward generalization to the N-point function are derived.
Transmitter-Embedded AMCC, LTE-A and OTDR signal for Direct Modulation Analog Radio over Fiber Systems (2018)

AMCC, LTE-A and OTDR signals are embedded in a single transmitter. Experiments show little impact on data transmission under in-service monitoring. Fault localization capability is verified with 10 dB dynamic range and 10 m resolution.
Raman scattering studies of biochemical changes associated with carcinogenesis using tumorigenic and non-tumorigenic cells (2002)

Analysis of Raman spectra from a pair of tumorigenic and non-tumorigenic cells derived from rat embryo fibroblast (REF) cells will be presented. M1 cells are an immortalized but non-tumorigenic cell line made by stable transfection with the myc oncogene. MR1 cells are a tumorigenic line derived from MI cells by stable transfection with a mutated ras oncogene. Using these two cell lines, biochemical changes caused by tumorigenesis may be characterized without spectral interference from intercellular components, such as collagen, that may change as a result of tumorigenic transformation. We will present our current results from Raman studies covering spectroscopic differences between the two cell lines, sampling the cells in both the plateau and exponential phases of growth. Raman data from isolated nuclei of the two cell lines are also presented. Where possible, differences in the Raman spectra will be correlated with biochemical differences observed using other techniques. For example, changes in nucleic acid content, which can be monitored by flow cytometry, are also observed in the Raman spectra. Changes in the relative amounts of proteins, lipids, and nucleic acids are also determined. Such abilities will be important in distinguishing between tumorigenic and non-tumorigenic cells in vivo.
Large B cell lymphoma--year by year. (2008)

Non Hodgkin's Lymphoma (NHL) comprises a group of lymphoproliferative disorders the frequency of which continues to rise. Although many classification systems exist for identifying specific histological subtypes, NHL is generally divided into indolent (low-grade) and aggressive (intermediate- and high-grade) forms. Large B Cell Lymphoma (LBCL) is one of the commonest aggressive NHLs. The aim of this review is to provide a general overview of NHL, its clinically practicable cellular classification, epidemiology and in depth overview of the evolution of treatment of LBCL during the past 5 years. Current guidelines from National Cancer Institute (NCI), USA and National Institute on Clinical Excellence (NICE), UK are mentioned and recommendations according to our own set-up are suggested.
Equine monoclonal antibodies recognize common epitopes on variants of equine infectious anaemia virus. (1990)

Equine-murine xenohybridoma cells were produced using SP2/0 murine myeloma cells and splenic lymph node cells obtained from horses infected with 10(6) TCID50 of single cloned variants of equine infectious anaemia virus (EIAV). The xenohybridomas secreted equine IgG monoclonal antibodies reactive with EIAV in enzyme immunoassays employing purified virus. Seven antibodies were studied in detail. They bound to viral glycoproteins (gp90 or gp45) in radioimmunoprecipitation assays, and reacted with homologous EIAV as well as five other cloned variants of EIAV. When evaluated against a single cloned variant of EIAV (EIAV-WSU5), two antibodies bound to different epitopes on gp90. The five remaining antibodies reacted with the same or overlapping epitopes on gp45. None of the antibodies exhibited viral neutralizing activity.
Semiempirical computational study of oxygen vacancies in a decahedral anatase nanoparticle (2018)

Abstract Formation of oxygen vacancies ( V O ) is an important step of many catalytic reactions following the Mars van Krevelen mechanism. High rate of oxidation is associated with low energy of V O formation while high selectivity requires an optimal energy of V O formation. In the present computational study, enthalpy of V O formation (Δ H OVF ) is studied in a decahedral anatase nanoparticle (TiO 2 ) 121 (H 2 O) 6 using PM6 method. Δ H OVF shows large variations for oxygen atoms in different locations on facets, edges and vertices. V O are much more stable in the (101) facet compared to the (001) facet, while internal V O are more stable for (101) but equally stable for (001) facet compared to surface vacancies on average. Comparison with literature DFT methods results reveals good consistency and high computational efficiency of the PM6 method for vacancies formation energy. Pm6 also correctly predicts admixture states of the Ti 3+ within the band gap, but absolute values of electronic band gap and position of admixture states is overestimated and needs scaling factors.
A Reel Braking System for Drip Lateral Handling Equipment (1986)

THE control of reel peripheral velocity during installa-tion of drip irrigation laterals is a major problem with present equipment. An improved braking system was developed using a rotary hydraulic actuator in a closed loop circuit in combination with a caliper disc brake. Laboratory evaluation indicated improved performance for implement speeds of 3 to 16 km/h.
<title>Perspective imagery in synthetic scenes used to control and guide aircraft during landing and taxi: some issues and concerns</title> (1995)

Perspective synthetic displays that supplement, or supplant, the optical windows traditionally used for guidance and control of aircraft are accompanied by potentially significant human factors problems related to the optical geometric conformality of the display. Such geometric conformality is broken when optical features are not in the location they would be if directly viewed through a window. This often occurs when the scene is relayed or generated from a location different from the pilot's eyepoint. However, assuming no large visual/vestibular effects, a pilot can often learn to use such a display very effectively. Important problems may arise, however, when display accuracy or consistency is compromised, and this can usually be related to geometrical discrepancies between how the synthetic visual scene behaves and how the visual scene through a window behaves. In addition to these issues, this paper examines the potentially critical problem of the disorientation that can arise when both a synthetic display and a real window are present in a flight deck, and no consistent visual interpretation is available.
DETERMINATION OF MINIMUM PERIOD BEFORE STRIKING ON REINFORCED CONCRETE FLEXURAL MEMBERS (1995)

En el presente trabajo se propone una metodologia para el establecimiento de plazos de descimbrado en elementos de hormigon armado solicitados a flexion, orientada a garantizar la satisfaccion de los estados limites ultimos y de servicio, tanto durante la construccion como a lo largo de la vida util de la estructura. Se proponen unas formulas muy simples que proporcionan valores minimos de las propiedades mecanicas del hormigon que deben ser alcanzadas en el instante del descimbrado, en funcion de los parametros geometricos, de la relacion entre el nivel de cargas al descimbrar y el de cargas totales de proyecto, de las cuantias de armaduras longitudinales y transversales y de los valores caracteristicos de las propiedades mecanicas de los materiales. Asi, mediante la realizacion de ensayos de informacion durante la construccion es posible determinar in situ el momento del descimbrado. Tambien es posible, conociendo las curvas de evolucion de las propiedades del hormigon en funcion del tipo de cemento y de las condiciones de curado, establecer a priori plazos de descimbrado. El metodo se ha utilizado en varios casos reales construidos en Barcelona en la fase pre-olimpica que requerian una gran velocidad de construccion, habiendo mostrado resultados muy satisfactorios, como se muestra en uno de los casos que se documenta a traves de un ejemplo.
Single-step formation of micron long (OH)3Al2O3Ge(OH) imogolite-like nanotubes (2013)

Micron-long germanium-based double-walled imogolite nanotubes were synthesized at high concentrations, as evidenced by cryo-TEM, AFM, SAXS and IR characterization methods. In addition, the spontaneous formation of a liquid-crystalline phase was observed. The novel synthesis route made it possible for the first time to obtain both long and concentrated germanium-based imogolite-like nanotubes in a single step.