gebhart/patrepeval huggingface dataset:
Expression of cyclooxygenase‐2 in prostate carcinoma (2000)

Nonsteroidal antiinflammatory drugs inhibiting cyclooxygenase (COX) enzyme activity in both its constitutive (COX-1) and inducible (COX-2) isoforms were shown also to inhibit the development of colon carcinoma in animal models. COX-2 is an inducer of angiogenesis of new blood vessels. The expression of COX-1 and COX-2 in prostate tissues from patients with prostate carcinoma was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry.
Tailoring of mechanical properties of derivatized natural polyamino acids through esterification and tensile deformation (2013)

Tensile deformation was applied to the naturally produced poly-γ-glutamic acid, which can be enzymatically degraded and is, therefore, of interest for biomedical use. However, natural polyamino acids have a similar chemical structure to synthetic polyamides (“nylons”), which are known to feature strong inter-molecular hydrogen bonding that prevents large-scale molecular motion in their solid state. Through esterification, this hydrogen bonding was partially shielded, allowing orientation of the polyamino acid macromolecules through tensile deformation. An increase in Young's modulus and tensile strength was achieved of solution-cast films of the chemically modified poly-γ-glutamic acids, consistent with enhanced uniaxial polymer chain orientation. The latter was confirmed by both wide-angle X-ray scattering and polarized Raman spectroscopy. The films thus produced were found to be non-cytotoxic. These mechanically tailorable, biocompatible polymers may be excellent candidates for use in musculoskeletal tissue engineering applications that have different loading requirements within the body.
Characterization of oxidic and organic materials with synchrotron radiation based XPS and XAS (2009)

The use of synchrotron radiation (SR) based X-ray absorption spectroscopy (XAS) and X-ray in-duced photoelectron spectroscopy (XPS) is demonstrated for the analysis of thin films. In the first part we report on oxidic films used for high-k dielectric films in Si technology and focus on a recent in-situ ap-proach to study the atomic layer deposition growth of HfO2 films. We demonstrate that even hidden layers can be characterized by using fluorescence technologies. In the second part, we demonstrate the suitability of SR based techniques for the analysis of organic thin films. Here, the first example deals with P(VDF-TrFE), a ferroelectric polymer, with possible applications in non-volatile memory devices. An-other example concerns the analysis of C60 based low-k polymers for use in Cu interconnect systems. Key words: synchrotron radiation spectroscopy; HfO2; high-k oxide; ultralow-k polymers 1.
[Sb<sub>12</sub>{(2‐MeO)C<sub>6</sub>H<sub>4</sub>N}<sub>18</sub>] · 6 THF: ein 24gliedriger Imido‐Sb<sup>III</sup>‐Metallacyclus (1996)

Aus sechs ringförmigen Sb 2 N 2 ‐Einheiten , die durch einfache Imidobrücken zu einer 24gliedrigen Ringstruktur verknüpft sind, ist die Titelverbindung aufgebaut (Strukturbild der zentralen Einheit rechts). Sie ist der größte strukturell charakterisierte Imidokomplex von Metallen der Gruppe 15 und die erste metallacyclische Imidoverbindung mit p‐Block‐Elementen. magnified image
Wind Power Plant Enhancement with a Fault-Current Limiter: Preprint (2011)

This paper investigates the capability of a saturable core fault-current limiter to limit the short circuit current of different types of wind turbine generators.
Validation of Insulin Resistance Indexes in a Stable Renal Transplant Population (2005)

All investigated insulin resistance indexes were valid estimates of insulin resistance in the long-term stable renal transplant population. However, correlation and agreement were strongest for McAuley's index. In addition to fasting insulin and triglyceride concentrations, of which McAuley's index is composed, only BMI seemed to be independently associated with insulin resistance in this population.
Biological Oxidations (1963)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
SYNOVIAL ENTRAPMENT (2002)

Background: We observed a complication of posterior stabilized total knee arthroplasty involving hypertrophy of tissue proximal to the patella associated with pain during active knee extension from 90° of flexion. The purpose of this paper was to describe synovial entrapment and to determine if design features of the prosthesis predispose patients to the complication. Methods: Between April 1990 and June 1999, we performed 459 consecutive posterior stabilized primary total knee arthroplasties using three prosthetic designs with different femoral intercondylar geometries. We identified twenty-six patients (twenty-seven knees) in whom arthroscopic débridement of the knee or open arthrotomy with débridement of the knee had been subsequently performed because of a diagnosis of synovial entrapment. We reviewed the records of these patients to identify the knee components that had been used and the symptoms and conditions that necessitated additional treatment. Results: Symptoms (grating, crepitation, and pain with active knee extension from 90°) necessitating subsequent débridement occurred in 13.5% (nineteen) of 141 knees treated with the Anatomic Modular Knee-Congruency implant, 3.8% (eight) of 212 treated with the Anatomic Modular Knee-Posterior Stabilized implant, and none of the 106 treated with the Press Fit Condylar Sigma-Posterior Stabilized implant. All patients had difficulty rising from a chair and climbing stairs; however, none had symptoms when standing or walking. No patient had a patellar clunk. The symptoms occurred at a mean of seven months after the arthroplasty in the patients with an Anatomic Modular Knee-Congruency implant and at a mean of twenty months after the arthroplasty in those with an Anatomic Modular Knee-Posterior Stabilized implant. Débridement of the frond-like hypertrophic synovial tissue at the distal aspect of the quadriceps tendon alleviated symptoms in all patients. No nodules were identified during the arthroscopy. Conclusions: Synovial entrapment is characterized by hypertrophic synovial tissue at the superior pole of the patella. Use of a posterior stabilized femoral component with a proximally positioned or wide femoral box is more likely to result in this complication.
An evaporative co-assembly method for highly ordered inverse opal films (2009)

Colloidal self-assembly holds promise for photonic applications as a solution-based, low-cost alternative to top-down photolithography, if significant control of uniformity and defects can be achieved. Herein we demonstrate a new evaporative co-assembly method for highly-uniform inverse opal thin films that involves the self-assembly of polymer colloids in a solution containing a silicate precursor. Nanoporous inverse opal films can be made crack-free and with highly uniform orientation at the cm scale. The silicate between the colloids appears to increase the strength against cracking. This control of defects makes this method well-suited for the low cost fabrication of such films as sensors and photonic devices.
Automotive virtual integration platforms: why's, what's, and how's (2003)

In this paper, we present the new concept of virtual integration platform for automotive electronics. The platform provides the basis for a novel methodology in which the integration of sub-systems is performed much earlier in the design cycle. As a result, cost reduction in the final implementation and in the design process can be achieved. In addition, early and repeatable fault analysis can be performed therefore easing the task of system safety proving.
Solid–solid–liquid reaction systems. A mechanistic study (1991)

The mechanism of the alkylation of phenoxide with benzyl bromide, catalysed by polymer-bound phase-transfer catalysts, has been studied as a model for solid–solid–liquid reaction systems. A ‘typical triphase catalyst’ has been compared with a commercial ion-exchange resin. The reactions proceed by a mechanism which is similar to the extraction mechanism of classical phase-transfer catalysis. Depending on the reaction conditions, the reaction rates are either mass-transfer controlled or chemical-reaction controlled. In some cases the C/O-alkylation ratio is found to depend on the water content of the system. The possible mechanisms for the transport of the phenoxide ion to the catalytic site are discussed.
Tandem Isomerization-Decarboxylation for Converting Alkenoic Fatty Acids into Alkenes (2014)

We report a facile Ru-catalyzed route to alkenes from unsaturated fatty acids (alkenoic fatty acids) via readily accessible catalyst precursors, [Ru(CO)2RCO2]n and Ru3(CO)12. The catalyst apparently functions in a tandem mode by dynamically isomerizing the positions of double bonds in an aliphatic chain and, subsequently, decarboxylating specific isomers with lower activation barriers. Substrates capable of tandem isomerization-decarboxylation processes (oleic acid, undecylenic acid) are readily converted to mixtures of alkenes. A catalytic cycle is proposed that relies on isomerization positioning double bonds proximate to the acid function to enable facile decarboxylation. To elucidate the proposed mechanistic pathway, substrates that do not undergo decarboxylation under these catalytic conditions (methyl oleate) are compared with those that cannot isomerize the position of unsaturation (cinnamic acid). Both were shown to be operational under these catalytic reaction conditions. Another illustrative comparison shows that the saturated octadecanoic acid is 28 times less reactive than the unsaturated counterpart when reacted using this precatalyst.
Derivatives of Sulfenic Acids. X. The Reaction of 2,4-Dinitrobenzenesulfenyl Chloride with Alcohols (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDerivatives of Sulfenic Acids. X. The Reaction of 2,4-Dinitrobenzenesulfenyl Chloride with AlcoholsNorman Kharasch, Duncan P. McQuarrie, and Charles M. BuessCite this: J. Am. Chem. Soc. 1953, 75, 11, 2658–2660Publication Date (Print):June 1, 1953Publication History Published online1 May 2002Published inissue 1 June 1953https://pubs.acs.org/doi/10.1021/ja01107a031https://doi.org/10.1021/ja01107a031research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Sodium Salt‐Splitting Performance of a Novel Ceramic‐Polymer Composite Cation‐Selective Membrane. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Restriction Map of <i>Rachiplusia ou</i> and <i>Rachiplusia ou-Autographa californica</i> Baculovirus Recombinants (1980)

The restriction sites of Rachiplusia ou nuclear polyhedrosis virus (RoMNPV) DNA were mapped for the endonucleases SmaI, KpnI, BamHI, SacI, XhoI, and EcoRI. Of the 60 DNA restriction sites of RoMNPV, 35 mapped in similar positions as compared to the restriction sites of Autographa californica nuclear polyhedrosis virus (AcMNPV) DNA. Two plaque-purified viruses, obtained from randomly picked plaques of a wild-type isolate of RoMNPV, were recombinants of RoMNPV and AcMNPV. The recombinants were shown to have RoMNPV and AcMNPV restriction fragments as well as structural polypeptides from each parental virus. Both recombinant viruses had a major RoMNPV capsid protein but were occluded in the AcMNPV polyhedrin protein.
ChemInform Abstract: METALLIERUNG VON IMINEN DES TYPS PH2C=NR 1. MITT. DIPHENYLMETHANIMIN, ANWENDUNG ZUR SYNTHSE PRIMAERER AMINE (1974)

Abstract Durch Lithiierung des Imins (I) mit Li‐Diäthylamid und Umsetzen des entstandenen Imids (II) mit den entsprechenden Alkylhalogeniden wurden die Imine (III) dargestellt, die bei der Hydrolyse neben Benzophenon (IV) die primären Amine (V) geben.
Comprehensive Bridge Scour Evaluation Methodology (2000)

In the United States, bridge scour technology is discussed primarily in three FHWA publications: Hydraulic Engineering Circular (HEC) 18: Evaluating Scour at Bridges; HEC-2: Stream Stability at Highway Structures; and HEC-23: Bridge Scour and Stream Instability Countermeasures. Together, these documents provide guidance to state highway agencies that is necessary for completing comprehensive scour and stream instability evaluations for the design of new bridges and for repairing existing bridges. Experience has shown that the relationships among the three documents are not always readily apparent, and some scour evaluations have relied primarily on HEC-18. A comprehensive flowchart that illustrates the interrelationship among the three FHWA scour-related documents has been developed. In addition, in 1998, FHWA, TRB, and AASHTO sponsored a scanning review of European practice for bridge scour and stream instability countermeasures. In 1999, ASCE published a compendium of papers on stream stability and scour at highway bridges, and FHWA prepared an annotated bibliography to support revisions to the three HECs. It is anticipated that the flow-chart and the substantial information from the scanning review, the compendium, and the annotated bibliography will be included in the next revisions to HEC-18, HEC-20, and HEC-23. On the basis of information from these sources, a comprehensive approach to bridge scour and stream instability evaluations is outlined, and an overview of planned revisions to the three FHWA HECs is provided.
Approximating covariance matrices using low rank perturbations with applications to accent identification and social network clustering (2010)

In this work, we present a new model, the Low-Rank Gaussian Mixture Model (LRGMM), for modeling data which can be extended to identifying partitions or overlapping clusters. This model is motivated by the effectiveness, yet limited scalability, of the Gaussian Mixture Model (GMM) for the problem of accent identification. The curse of dimensionality that arises in calculating the covariance matrices of the GMM is countered by using low-rank perturbed diagonal matrices. We also demonstrate the LRGMM for finding communities in social networks. We see that the efficiency of the LRGMM allows us to process larger networks than alternative approaches. Altogether, the LRGMM experiments reveal it to be a efficient and highly applicable tool for working with large high-dimensional datasets.
Digital Image Speckle Correlation (DISC) Analysis for Targeted Cosmetic Treatment and Effect Quantification of Botulinum Toxin Type A (2013)

INTRODUCTION: Administration of Botulinum Toxin (BT) for the cosmetic treatment of facial wrinkles has traditionally been determined using anatomic landmarks, with effect monitored by subjective assessment tools and questionnaires.1 Our study applied DISC analysis, a novel, non-invasive technique that measures facial muscle animation, to select injection locations as well as quantify degree of paralysis and time to recovery. DISC analyzes skin deformation to measure the magnitude and direction of facial muscle contraction.2 Vector profiles indicate points of maximal tension and thus ideal injection sites. Using pre-treatment and follow-up DISC data, we characterized patients’ facial muscle recruitment and compared it with subjective cosmetic effect and satisfaction. METHODS: 9 female Caucasian patients aged 30-65 were photographed prior to BT treatment in a uniform position using a head stabilizer, with the face at rest and engaging the muscle group of interest (glabellar and forehead). DISC analysis identified vector convergence points, representing ideal injection locations (Figure 1). Each patient received a total 50 units of BT among sites in the upper face determined using DISC. Photos were taken at each follow-up (3 days, 1 week, 2 weeks, 3 weeks, 4 weeks, 8 weeks, 12 weeks). DISC analysis quantified changes in muscle recruitment, as measured by percent decrease in contraction strength from baseline. DISC data was corroborated with patient satisfaction using the Facial Line Outcomes 11-item survey (FLO-11).Figure 1: DISC-generated vector diagram showing points of maximal stress in areas of vector convergence.RESULTS: Average injection number was 16±2 among subjects, and paralysis was seen in all patients by day 3. Maximum paralysis (-0.638±0.11) was detected with DISC on day 28, which also correlated with the maximum reported benefit as measured by FLO-11 (0.427± 0.05) (Figure 2). DISC demonstrated recovery at day 56 (-0.464±0.15) with a concurrent drop-off in mean FLO-11 scores. CONCLUSION: DISC determines ideal injection locations prior to cosmetic treatment with BT toxin by identifying the skin’s points of maximal stress. DISC quantifies subtle changes in contraction strength, corresponding to cosmetic effect duration. DISC is a reliable, objective metric for aesthetic outcomes, enabling clinicians to provide an accurate prediction of treatment effect and duration to their patients.
Isolation and reconstitution of a vacuolar-type proton pump of osteoclast membranes. (1994)

A vacuolar-type proton-translocating ATPase was extracted from ruffled membranes of chicken osteoclasts with 1% polyoxyethylene 9-lauryl ether (C12E9) and was purified 13-fold by glycerol gradient centrifugation. The isolated pump appears by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to have a subunit composition similar to that of the clathrin-coated vesicle proton pump, in that subunits of apparent molecular masses of 116, 71, 57, 40, 39, 33, and 17 kDa are present in the osteoclast pump preparation. In addition, the 116-, 71-, 57-, and 40-kDa components were shown to cross-react with specific antisera generated against the homologous subunits of the clathrin-coated vesicle proton pump. The isolated osteoclast H(+)-ATPase was reconstituted into liposomes prepared from purified lipids (phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and cholesterol) by a cholate-dilution, freeze-thaw method. Proton transport catalyzed by the reconstituted pump was inhibited by bafilomycin A1 (10 nM) and N-ethylmaleimide (1 mM) but was insensitive to vanadate. We propose that osteoclast-mediated bone resorption is effected by a vacuolar-type proton pump with functional and structural similarities to that isolated from clathrin-coated vesicles.
Measurement of the Dynamics of Exocytosis and Vesicle Retrieval at Cell Populations Using a Quartz Crystal Microbalance (2001)

The quartz crystal microbalance-dissipation technique (QCM-D) is used in two different measurement strategies to monitor the mass change and rigidity of populations of excitable cells during exocytosis and subsequent retrieval of dense-core vesicles. Two cell lines, NG 108-15 and PC 12, were grown to confluence on piezoelectric quartz crystals and were examined separately to demonstrate differences in release and retrieval with cells of different morphology, size, and number of dense-core vesicles. Stimulating the cells to exocytosis with media containing an elevated potassium concentration resulted in an increase in the frequency response corresponding to loss of mass from the cells owing to release of vesicles. In Ca2+-free media, the response was completely abolished. The amplitude and peak area in the frequency response corresponding to mass change with stimulated release was larger for PC 12 cells than for NG 108-15 cells, whereas the initial rate constants for the frequency responses were similar. The data suggest (1) that a greater number and larger size of vesicles in PC 12 cells results in a greater amount of release from these cells vs NG 108-15 cells, (2) the recycling of vesicles utilizes similar fusion/retrieval mechanisms in both cell types, (3) that the control of excess retrieval might be related to the number and size of released vesicles, and (4) that measured retrieval has a rapid onset, masking exocytosis and implying a rapid retrieval mechanism in the early stages of release. These results demonstrate that measurements of complex dynamic processes relating to dense-core vesicle release and retrieval can be simultaneously accomplished using the QCM-D technique.
CCDC 1053620: Experimental Crystal Structure Determination (2013)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells (2002)

These results suggest that the impaired expression of proteasome subunits is involved in the loss of HLA class I expression in human colon cancer cells.
A 2.4GHz Common-Gate LNA Using On-Chip Differential Inductors in a 0.18&#x0B5;m CMOS Technology (2009)

A 2.4 GHz CMOS differential common-gate low noise amplifier (CGLNA) is presented. It utilizes two on-chip differential inductors instead of four on-chip single-ended inductors in traditional designs, resulting in significantly reduced die area. Furthermore, two noise reduction techniques, i.e. capacitive cross-coupling and MOSFET channel length optimization, are discussed. A prototype was fabricated in a 0.18 mum RF CMOS process, and was packaged for testing. The measurement results are in agreement with circuit simulations.
Computer-Automated Structure Evaluation (CASE) of Retinoids in Teratogenesis Bioassays (1990)

Computer-Automated Structure Evaluation (CASE) of Retinoids in Teratogenesis Bioassays. FRIERSON, M. R., MIELACH, F. A., AND KOCHHAR, D. M. (1990). Fundam. Appl. Toxicol. 14, 408–428. The potential usefulness of the retinoids, a large group of synthetic compounds chemically and structurally related to vitamin A, in the treatment of severe dermatologic diseases and in the prophylaxis and therapy against cancer is severely limited because of their potential teratogenicity. CASE analysis of published retinoid data from the hamster teratogenic-ity assay and the limb bud “spot” culture system has targeted the hydrophobic region of the retinoids as having the greatest effect on the range of potencies studied. In addition, log p's (as calculated by the CASE program) below a certain value appear to unilaterally result in nontera-togenic retinoids in the In vivo hamster assay system.
Endovascular stent repair of traumatic cervical internal carotid artery injuries (2013)

Jindal, Gaurav MD; Fortes, Manuel MD; Miller, Timothy MD; Scalea, Thomas MD; Gandhi, Dheeraj MD Author Information