gebhart/patrepeval huggingface dataset:
Integrin β Cytoplasmic Domains Differentially Bind to Cytoskeletal Proteins (1998)

Integrin cytoplasmic domains connect these receptors to the cytoskeleton. Furthermore, integrin-cytoskeletal interactions involve ligand binding (occupancy) to the integrin extracellular domain and clustering of the integrin. To construct mimics of the cytoplasmic face of an occupied and clustered integrin, we fused the cytoplasmic domains of integrin beta subunits to an N-terminal sequence containing four heptad repeat sequences. The heptad repeats form coiled coil dimers in which the cytoplasmic domains are parallel dimerized and held in an appropriate vertical stagger. In these mimics we found 1) that both conformation and protein binding properties are altered by insertion of Gly spacers C-terminal to the heptad repeat sequences; 2) that the cytoskeletal proteins talin and filamin are among the polypeptides that bind to the integrin beta1A tail. Filamin, but not talin binding, is enhanced by the insertion of Gly spacers; 3) binding of both cytoskeletal proteins to beta1A is direct and specific, since it occurs with purified talin and filamin and is inhibited in a point mutant (beta1A(Y788A)) or in splice variants (beta1B, beta1C) known to disrupt cytoskeletal associations of beta1 integrins; 4) that the muscle-specific splice variant, beta1D, binds talin more tightly than beta1A and is therefore predicted to form more stable cytoskeletal associations; and 5) that the beta7 cytoplasmic domain binds filamin better than beta1A. The structural specificity of these associations suggests that these mimics offer a useful approach for the analysis of the interactions and structure of the integrin cytoplasmic face.
Network Coding versus Replication Based Resilient Techniques to Mitigate Insider Attacks for Smart Metering (2015)

The main focus of this paper is the resilience of communication protocols for data gathering in distributed, large scale, and dense networks. In our previous work, we have proposed the resilient methods based on random behavior and data replications to improve route diversification, thus to take advantage of redundant network structure. Following these previous methods, we propose in this paper a new resilient method based on network coding techniques to improve resilience in Wireless Sensor Networks (WSNs) for smart metering applications. More precisely, using our resilience metric based on a performance surface, we compare several variants of a well-known gradient based routing protocol with the previous methods (random routing and packet replications) and the new proposed methods (two network coding techniques). The proposed methods outperformed the previous methods in terms of data delivery success even in the presence of high attack intensity.
Design of the ramp generator for UIRFPA (2012)

This paper designs a ramp generating circuit using for uncooled infrared focal plane arrays (UIRFPA). Compared with the basic ramp generator, the new generator is highly adjustable, easy to operate, and adaptable. By adjusting the total current of the charging circuit, it can realize the ramp wave upper point and slope of the modulation. Current mirror as the discharge load, it can adjust the ramp lower point, and controllable capability. By adjusting accuracy and swing, the new ramp generator for UIRFPA provides a way to adapt to the strength of the infrared scene to control the infrared signal accuracy. Simulation results show that the ramp output swing can be adjusted from 1 V to 4.5 V, a maximum Integral nonlinearity (INL) of 400 µV, a slope distortion lower than 0.01%, linearity higher than 13 bits for the new ramp generator (considering a 4 V input range). At the same time, its good temperature performance shows that the maximum difference of the output voltage is 50 mV in a variety of environments (243 K ~ 333 K). Besides, this circuit has been successfully applied to the infrared system.
Possible mechanism for d<sup>0</sup> ferromagnetism mediated by intrinsic defects (2014)

We present insights into the role of vacancies and surface states in the d<sup>0</sup> ferromagnetism of ZnS nanostructures.
Distribution of B52 within a chromosomal locus depends on the level of transcription. (1994)

Drosophila B52 protein is a homologue of human ASF/SF2 that functions in vitro as an essential pre-mRNA splicing factor. Immunofluorescence analysis of polytene chromosomes has shown that B52 generally colocalizes with RNA polymerase II; however, in contrast to other splicing factors, B52 brackets RNA polymerase II at highly active heat-shock puffs. Also, UV cross-linking in nonpolytene cells has shown that B52 cross-links in vivo to DNA flanking the highly active transcription units. Here, we find that the distribution of cross-linked B52 at heat-shock loci depends on transcription levels. Heat shocks at low and moderate temperatures, which induce corresponding levels of transcription, recruit B52 both to transcribed DNA and to flanking DNA, whereas a full heat-shock induction concentrates B52 on the DNA that brackets the entire activated region. We have also identified a 46-kDa protein from Chironomus tentans that binds Drosophila B52 antibodies and has a distribution on chromosomes analogous to B52. This protein is found throughout the moderately transcribed Balbiani rings. However, when transcription at these rings is hyperinduced to levels comparable to fully induced Drosophila heat-shock genes, the protein is restricted to the boundaries of highly decondensed chromatin. We suggest that B52 tracks to chromatin fibers that are folding or unfolding, and we discuss this in light of B52's proposed roles in pre-mRNA splicing and control.
Self-assembly of alkane capped silver and silica nanoparticles (2002)

Silver and silica nanoparticles stabilised by long chain alkanes have been prepared and characterised using 1H-NMR, transmission electron microscopy (TEM) and small-angle X-ray scattering (SAXS). Upon solvent evaporation, the alkane stabilised silica and silver nanoparticles self-assemble into close-packed two- and three-dimensional structures. Furthermore, it is shown that a mixture of large silica (90 Å) and small silver (48 Å) nanoparticles self-assemble into mixed well-defined close-packed structures. It has been demonstrated that particle size, core material and solvent composition can be employed to control the forces between individual nanoparticles and, consequently, the structure of the self-assembled arrays. These mixed structures have also been studied using UV-visible spectroscopy and their collective optical properties are shown to depend on their overall composition.
Molecular weight distributions of polydisperse systems: application to very low density lipoproteins (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular weight distributions of polydisperse systems: application to very low density lipoproteinsSteven T. Kunitake, Eugene Loh, Verne N. Schumaker, Shun Kin Ma, Charles M. Knobler, John P. Kane, and Robert L. HamiltonCite this: Biochemistry 1978, 17, 10, 1936–1942Publication Date (Print):May 16, 1978Publication History Published online1 May 2002Published inissue 16 May 1978https://pubs.acs.org/doi/10.1021/bi00603a021https://doi.org/10.1021/bi00603a021research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Estimation of Maximum Liquid Head over Landfill Barriers (2004)

To properly design a drainage layer for either landfill leachate collection systems or final covers, the designer must be able to estimate the maximum liquid head over the barrier for any proposed configuration. This paper presents four explicit formulas for estimating the maximum liquid head over an impervious sloping barrier. By means of numeric comparisons, McEnroe’s 1993 method is recommended for design of drainage layers for both bottom liners and final covers. Pipe slope is an important parameter that influences the maximum leachate head on the liner. Different combinations of base grade and pipe slope can directly affect the actual drainage behavior. If the pipe slope is steeper than the base grade, it will make a longer drainage distance and cause a high leachate head on the liner. A method for calculating the maximum liquid head in multilayered drainage media (e.g., geosynthetic and soil) is presented in the paper. The key consideration for this case is to determine the equivalent hydraulic conductivity of the combined drainage media under the phreatic surface under unconfined seepage conditions.
Photoreactions of o-quinones with olefins: mechanism of the 1,4-cycloaddition (1967)

S. Farid, Chem. Commun. (London), 1967, 1268 DOI: 10.1039/C19670001268
Defect formation during deposition of undoped a-Si:H by rf glow discharge (1997)

Dependence of the as-grown defect concentration in undoped a-Si:H deposited by rf glow discharge on the deposition parameters is investigated. It is found that the defect density behaves similarly to the concentration of ${\mathrm{SiH}}_{2}$ configuration in the films deposited at substrate temperatures below 300 \ifmmode^\circ\else\textdegree\fi{}C. The defect concentration varies proportionally to about the third to fourth power of the ${\mathrm{SiH}}_{2}$ concentration depending on the deposition conditions. The Urbach energy increases in samples deposited under the condition where ${\mathrm{SiH}}_{2}$ concentration increases. An additional energy is necessary to convert the weak bond in the valence-band tail into the defect. The observed characteristics are analyzed by a model in which this additional energy is produced by the surface reaction of ${\mathrm{SiH}}_{3}$ incorporating the ${\mathrm{SiH}}_{2}$ configuration into the network. These characteristics are compared with those of the Staebler-Wronski effect. The increase of weak bond density contributes to the increase of defect creation efficiency. The analyses give a quantitative explanation of the observed characteristics and estimation of some parameters involved in the conversion process. Similarities in the mechanisms are pointed out between the as-deposited defect formation and the Staebler-Wronski effect.
Phase III Study Comparing Vincristine, Doxorubicin (Adriamycin), and Dexamethasone (VAD) Chemotherapy with VAD Plus Recombinant Interferon Alfa-2 in Refractory or Relapsed Multiple Myeloma (1995)

This study shows no advantage to the use of interferon combined with VAD in refractory or relapsing myeloma. However, the small sample size decreased the statistical power to recognize small differences if present. Moreover, the survival data do not suggest a clear advantage to the administration of vincristine or doxorubicin as a 96-hour infusion compared with results of studies using bolus administration combined with high-dose corticosteroids.
CarSpeak (2012)

This paper introduces CarSpeak, a communication system for autonomous driving. CarSpeak enables a car to query and access sensory information captured by other cars in a manner similar to how it accesses information from its local sensors. CarSpeak adopts a content-centric approach where information objects -- i.e., regions along the road -- are first class citizens. It names and accesses road regions using a multi-resolution system, which allows it to scale the amount of transmitted data with the available bandwidth. CarSpeak also changes the MAC protocol so that, instead of having nodes contend for the medium, contention is between road regions, and the medium share assigned to any region depends on the number of cars interested in that region. CarSpeak is implemented in a state-of-the-art autonomous driving system and tested on indoor and outdoor hardware testbeds including an autonomous golf car and 10 iRobot Create robots. In comparison with a baseline that directly uses 802.11, CarSpeak reduces the time for navigating around obstacles by 2.4x, and reduces the probability of a collision due to limited visibility by 14x.
Collapse in High-Grade Stenosis during Pulsatile Flow Experiments (2004)

It has been hypothesized that blood flow through high grade stenotic arteries may produce conditions in which elastic flow choking may occur. The development of atherosclerotic plaque fracture may be exacerbated by the compressive stresses during collapse. This study explored the effects of pulsatile flow on stenotic flow collapse. Pulsatile flow was produced using a gear pump controlled by a digitized physiologic waveform. Upstream and downstream mean pressures and pulsatile flow rates were measured and digitized. An improved model of arterial stenosis was created using an elastomer with an incremental modulus of elasticity matched to a bovine carotid artery in the relevant range of collapse. Additionally, the model retained a very thick wall in the stenotic region similar to arterial disease. Flow choking was observed for pulsatile pressure drops close to those previously reported for steady flow. The phase difference between flow rate and pressure between upstream and downstream of the stenosis occurred by the compliance of tube and stenosis resistance. For 80% nominal stenosis by diameter and 100+/-30mmHg upstream pressure, collapse occurred for average pulsatile pressure drops of 93mmHg. Pulsatile flow experiments in this model revealed the range of conditions for the flow choking and the paradoxical collapse of the stenosis during systole with expansion during diastole. The stenosis severity was dynamic through the pulse cycle and was significantly greater under flow than the nominal severity. The results indicate that flow choking and stenotic compression may be significant in thick-walled arterial stenoses subjected to pulsatile flow.
The Informatics Response in Disaster, Terrorism, and War (2002)

The United States currently faces several new, concurrent large-scale health crises as a result of terrorist activity. In particular, three major health issues have risen sharply in urgency and public consciousness--bioterrorism, the threat of widespread delivery of agents of illness; mass disasters, local events that produce large numbers of casualties and overwhelm the usual capacity of health care delivery systems; and the delivery of optimal health care to remote military field sites. Each of these health issues carries large demands for the collection, analysis, coordination, and distribution of health information. The authors present overviews of these areas and discuss ongoing work efforts of experts in each.
Boundary problems for additive processes defined on a finite Markov chain (1965)

In a previous paper (3), to which this is a sequel, a central limit theorem was presented for the homogeneous additive processes defined on a finite Markov chain, a class of processes treated extensively by Miller (4). A typical homogeneous process { R ( t ), X ( t )} takes its values in the space and is described by a vector distribution F( x, t ) with components and an increment matrix distribution B(x) governing the transitions. The present paper treats the motion of the process in the same space when its homogeneity is modified by the presence of a set of boundary states in x. Such bounded processes have many applications to the theory of queues, dams, and inventories. Indeed, this paper and its predecessor were motivated initially by a desire to discuss queuing systems with many servers and many service phases. We will treat both absorbing boundaries and associated passage time densities, and reflecting boundaries. For the latter our main objective is an asymptotic discussion of the tails of the ergodic distribution.
A second-level cache with the distance-aware replacement policy for NUMA systems (2002)

Many problems in medicine and biology involve some kind of spatial spread, and quite often the need to control it. A large proportion of medical and biological systems distinguish themselves from those found in engineering by the way the control acts. We illustrate this by considering the specific example of the spread of rabies among foxes. We first give a brief description of a model proposed by Murray et al. (Murray, J. D., Stanley, E. A. & Brown, D. L., Proc. R. Soc. Lond., B 229, 111-150 (1986)), which we extend to include the control mechanism. The problem is to prevent the spread of rabies by vaccinating foxes via the distribution of bait in a region around an observed outbreak. The extended model can be formulated as a nonlinear time-varying control system described by partial differential equations. In contrast to most engineering type control problems, the control does not continuously affect the system but only acts through the initial distributions. We briefly outline a general theory developed for dealing with such nonlinear systems by the use of a fixed point theorem. The problem and the theory are illustrated by some numerical simulations.
A forecast of new test capabilities using Magnetic Suspension and Balance Systems (1988)

This paper outlines the potential of Magnetic Suspension and Balance System (MSBS) technology to solve existing problems related to support interference in wind tunnels. Improvement of existing test techniques and exciting new techniques are envisioned as a result of applying MSBS. These include improved data accuracy, dynamic stability testing, two-body/stores release testing, and pilot/designer-in-the-loop tests. It also discusses the use of MSBS for testing exotic configurations such as hybrid hypersonic vehicles. A new facility concept that combines features of ballistic tubes, magnetic suspension, and cryogenic tunnels is described.
Contribution à l’étude des hyperkératoses équines (1939)

En relatant un cas d'hyperkratose amiantace quine localise dans la Revue vtrinaire militaire (
Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance (2019)

Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAF<sup>V600E</sup>-melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated by the TFEB transcription factor. TFEB is phosphorylated and thus inactivated by BRAF<sup>V600E</sup> via its downstream ERK independently of mTORC1. BRAFi disrupts TFEB phosphorylation, allowing its nuclear translocation, which is synergized by increased phosphorylation/inactivation of the ZKSCAN3 transcriptional repressor by JNK2/p38-MAPK. Blockade of BRAFi-induced transcriptional activation of autophagy-lysosomal function in melanoma xenografts causes enhanced tumor progression, EMT-transdifferentiation, metastatic dissemination, and chemoresistance, which is associated with elevated TGF-β levels and enhanced TGF-β signaling. Inhibition of TGF-β signaling restores tumor differentiation and drug responsiveness in melanoma cells. Thus, the "BRAF-TFEB-autophagy-lysosome" axis represents an intrinsic regulatory pathway in BRAF-mutant melanoma, coupling BRAF signaling with TGF-β signaling to drive tumor progression and chemoresistance.
Partial purification of a triacylglycerol lipase isolated from steelhead trout (<i>Salmo gairdneri</i>) adipose tissue (1984)

Abstract A triacylglycerol (TG) lipase (EC 3.1.1.2), assayed by monitoring [1‐ 14 C]‐oleic acid release from [carboxyl‐ 14 C]‐triolein after liquid‐liquid partition of the fatty acid from the unhydrolyzed triacylglycerol substrate, was isolated and partially purified from steelhead trout adipose tissue. The TG lipase was resolved from contaminating lipoprotein lipase by heparin‐sepharose affinity chromatography and purified ca. 71‐fold over the original fraction. Optimal enzyme activity occurred at pH 7.5. The purified enzyme migrated on SDS‐polyacrylamide gels with an apparent molecular weight of 48,000.
ChemInform Abstract: S1‐S0 Transition of N,N‐Diethylaniline: Vibrational Assignments and Picosecond Dynamics. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Increased synthesis and accumulation of phospholipids during differentiation of 3T3-L1 cells into adipocytes. (1983)

Conversion of 3T3-L1 preadipocytes to fully developed adipocytes in culture under the influence of dexamethasone, 1-methyl-3-isobutyl xanthine, and insulin offers a unique system to investigate differentiation-related changes in lipid metabolism. Depending on the type of isotopic precursors ([3H2]O, 32Pi, and [1-14C]acetate) used, a 10-170-fold increase in the rate of incorporation into lipid was observed in 3T3-L1 adipocytes which contained 5-10-fold higher amounts of cellular protein/culture than preadipocytes. In preadipocytes and adipocytes, the major lipids synthesized were phospholipids, triglycerides, and fatty acids. The rate of 32Pi incorporation into total lipids was 21-fold higher in adipocytes than that in preadipocytes, and 90% of the total radioactivity in both preadipocytes and adipocytes was contributed by phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). The content of phospholipids was 7-8-fold higher/culture in adipocytes than that in preadipocytes, and 65 and 80% of the total phospholipids of preadipocytes and adipocytes, respectively, were composed of PC and PE. Based on DNA measurements, there was a 3-fold increase in phospholipids and an approximately 3-fold increase in protein/cell. During 3T3-L1 adipose conversion, a detectable increase in cellular protein, triglycerides, and phospholipids was observed on day 3 after induction and, thereafter, these constituents increased continuously up to day 11. Among the different phospholipids of both preadipocytes and differentiating 3T3-L1 cells, PC, PE, and PI exhibited significant changes in their rate of 32Pi incorporation during adipogenesis. While there was a continuous increase in the incorporation of 32Pi into PI, there was preferential incorporation of 32Pi into PC and PE, the significance of which is not clear. The increase in phospholipids and protein content during adipogenesis suggests that phospholipids are required for membrane biosynthesis.
ChemInform Abstract: Aerobic Enantioselective Epoxidation of Unfunctionalized Olefins Catalyzed by Optically Active Salen‐Manganese(III) Complexes. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.