gebhart/patrepeval huggingface dataset:
The Role Of Percutaneous Transvenous Balloon Mitral Valvuloplasty In The Treatment Of Patients With Symptomatic Mitral Stenosis (1992)

Since its introduction in 1984, percutaneous transvenous mitral balloon valvuloplasty (PTMV) has emerged as an effective technique in the treatment of selected patients with severe mitral stenosis. The most important factors determining the haemodynamic and clinical outcome after PTMV are the anatomic and pathological features of the mitral valve apparatus. In patients with pliable, non-calcified valves, immediate success rates of well over 90% are achieved. Short-term follow-up studies of such patients after PTMV demonstrate a low rate of valve restenosis, with the vast majority of patients remaining much improved clinically. Less favourable immediate and short-term results are observed in patients who have non-pliable, calcified valves. Major acute complications of PTMV include thromboembolic events and the production of severe mitral regurgitation. It appears that, as a result of increased operator experience, better patient selection and refinements in the technique of PTMV, the rates of these acute complications are now very low. Follow-up studies will be needed to assess the long-term efficacy of the procedure. The first publications on this field are encouraging.
TONE DISTRIBUTION AND ITS EFFECT ON SUBGLOTTAL PRESSURE DURING SPEECH (2007)

The current work is part of a project to character-ize the subglottal pressure (Ps) contour associated with a spoken utterance in terms of the distribution of pitch accents and of phrase and boundary tones. It is found that the nuclear pitch accent does not define the start of the termination phase; the utterance off-set is a better marker. Declination rate of the work-ing phase and its relation to the phrase and bound-ary tones at utterance offset are found to vary among speakers. The results have implications for models of speech production, and for applications such as computer speech synthesis and recognition.
Highly Conductive Bilayer Transparent Conducting Oxide Thin Films for Large-Area Organic Photovoltaic Cells (2009)

Highly conductive In-doped CdO/Sn-doped In2O3 (CIO/ITO) bilayer transparent conducting oxide (TCO) thin films were prepared by combining, in sequence, metal-organic chemical vapor deposition (MOCVD) and ion-assisted deposition (IAD) techniques. The bilayer substrates, with a low In content of ∼19 atom % and a low sheet resistance of only ∼4.9 Ω/◻, were investigated as anodes in the bulk-heterojunction (BHJ) organic photovoltaic (OPV) devices using poly(2-methoxy-5-(3′,7′-dimethyloctyloxy)-1,4-phenylenevinylene) (MDMO-PPV):[6,6]-phenyl C61 butyric acid methyl ester (PCBM) as the active layer. The bilayer anode OPVs of the current laboratory size (∼0.06 cm2) exhibit performance comparable to those of commercial ITO-based control devices. The effect of TCO conductivity on OPV performance in larger area devices is analyzed through a simulation model. The results reveal significant advantages of using the highly conductive bilayer TCO anodes for large-area OPV cells.
Special Care and School Difficulties in 8-Year-Old Very Preterm Children: The Epipage Cohort Study (2013)

Objectives: To investigate school difficulties, special care and behavioral problems in 8 year-old very preterm (VPT) children. Patient and Methods: Longitudinal population-based cohort in nine regions of France of VPT children and a reference group born at 39–40 weeks of gestation (WG). The main outcome measures were information about school, special care and behavioral problems using Strengths and Difficulties Questionnaire from a questionnaire to parents. Results: Among the 1439 VPT children, 5 % (75/1439) were in a specialised school or class, 18 % (259/1439) had repeated a grade in a mainstream class and 77 % (1105/1439) were in the appropriate grade-level in mainstream class; these figures were 1 % (3/327) , 5 % (16/327) and 94 % (308/327) , respectively, for the reference group. Also, 15 % (221/1435) of VPT children in a mainstream class received support at school versus 5 % (16/326) of reference group. More VPT children between the ages of five and eight years received special care (55 % (794/1436)) than children born at term (38 % (124/325));
PHARMACOKINETICS/PHARMACODYNAMIC PROFILES OF AFRICAN AMERICANS (AA) IN A PHASE II RANDOMIZED PLACEBO-CONTROLLED TRIAL OF SIROLIMUS (RAPA) IN RENAL TRANSPLANTATION (1999)

296 This double blind trial, conducted in Australia, Europe and N. America, enrolled 576 primary renal transplant patients ≥ 13 years of age with ESRD. Patients were randomized to receive daily doses of CsA/corticosteroids, plus either RAPA (2 or 5 mg) or placebo. There were 66 AA patients enrolled: n=26, 2 mg RAPA; n=20, 5 mg RAPA; and n=13, PBO. Demographic features of AA patients were similar to non-AA patients with the exceptions of frequency of cadaveric donor (91%, AA vs 76% non-AA) and mean HLA match (4.0 ± 0.196, AA vs 3.4 ± 0.062, non-AA). Pharmacokinetics Results: There were no differences among AA and non-AA patients with respect to average RAPA dose (p=0.84) or whole blood trough concentrations of RAPA (p=0.89). AA patients required significantly higher average doses of CsA than non-AA patients (p=0.001, by model). Although no significant differences were found between AA and non-AA patients with respect to normalized whole blood trough CsA levels, AA patients had significantly higher actual trough CsA levels compared to non-AA patients (p=0.007), mainly due to elevated CsA concentrations in the 2 mg/day RAPA group during month 1. (Table)TablePharmacodynamic Results: Regression analysis of selected laboratory values with respect to race showed higher serum LDH and potassium levels, as well as white blood cell count in AA patients that in non-AA patients (p<0.001, p=0.009, p=0.008, respectively). Serum cholesterol and triglyceride as well as Nankivell GFR were significantly lower in AA vs non-AA patients (p=0.01, p=0.005, p<0.001, respectively). Overall univariate logistic regression analysis showed that race was not a significant predictor of acute rejection when analyzed as an individual variable. Conclusions: AA patients who received RAPA plus CsA/corticosteroids had RAPA PK profiles that were no different than those in non-AA patients. Regression analysis of race on safety (laboratory) endpoints showed a mixed effect in AA patients vs non-AA patients. Logistic regression analysis of an efficacy (acute rejection) endpoint showed that race was not a predictive variable. Grant support Wyeth-Ayerst Research.
Antibody tests for ocular toxoplasmosis. (1962)

The recently modified fluorescence inhibition test for antibodies to toxoplasmosis is safe and relatively simple to perform. It appears to detect antibodies early in the course of acute systemic infection but is less sensitive than either the dye test or hemagglutination test in detecting chronic infection. Although hemagglutinating antibodies develop later than dye test antibodies in the course of acute systemic toxoplasmosis, the hemagglutination test correlates very well in titer ivith serum from patients toith subacute or chronic infection, such as that seen in ocular disease. Since most of the proved cases of ocular toxoplasmosis have low dye titers that might well be undetected in the less sensitive FI test, this test appears to be inadequate for the study of ocular toxoplasmosis.
Correlation of the Solubilities of Aluminum Hydroxides and Oxyhydroxides in Alkaline Solutions with the Thermodynamic Properties of Al(OH){sub 4}{sup -} (1990)

The solubilities of gibbsite, boehmite and diaspore in alkaline solutions between 20 and 350C are evaluated and their thennodynamic properties reconciled.The thennodynamic properties of the aluminate ion, Al(OH).$,are derived over the same temperature range and compared with predictions based on the revised Helgeson-Kirkham-Flowers equation of state.Preliminary thermodynamic properties o(bayerite and .1Gu98 for nordstrandite are also derived from solubility data in alkaline solutions.Log K 54 values for gibbsite, bayerite, boehmite and diaspore between 0 and 350C, and thermodynamic data for Al(OH)4 or Al02, are tabulated for use in distribution-of-species computer codes.
Spatio‐temporal motility MRI analysis of the stomach and colon (2019)

Spatio-temporal motility MRI analysis of the stomach and colon correlates well with reader scores in a range of datasets and provides both a quantitative and qualitative means of assessing contractile activity in the gastrointestinal tract.
ChemInform Abstract: Synthesis and Characterization of Coordinately Unsaturated Phosphine Complexes of Divalent V, Cr, Mn, Fe, and Co. Crystal Structures of (CrCl2(dippe))2 and FeCl2(dippe). (1988)

Abstract The dihalidodiphosphine‐metal(II) complexes (III), (V), (VIII) are prepared according to the scheme.
Multiplicity of cross‐reactive epitopes on <i>Bet v</i> I as detected with monoclonal antibodies and human IgE (1995)

Six monoclonal antibodies against Bet v I, the major cross-reactive allergen of birch pollen (Betula verrucosa), were obtained. Four did not react with fruits, but two monoclonal antibodies (mAbs) (5H8 and 9C11) were reactive with apple and other fruits. These two cross-reactive antibodies reacted with identical or overlapping sites, but differed in their relative degree of cross-reactivity toward various fruits and hazelnut. Cross-reactive human IgE antibodies reacted with a nonoverlapping epitope, as indicated by results of a two-site radioimmunoassay (RIA) with the fruit-reactive mAb 9C11. By isoelectric focusing (IEF) in conjunction with immunoblotting, a maximum of seven isoforms could be distinguished. Depletion of birch-pollen extract for Bet v I with the most reactive mAb (7F7) removed approximately 95% of the IgE cross-reactivity between birch pollen and apple extract. The remaining 5% cross-reactive material was still capable of inhibiting the binding of IgE to apple allergen completely, and was reactive with mAbs 5H8 and 3C4. By means of IEF/immunoblot, it was shown that these mAbs recognize an isoform of Bet v I that is poorly, if at all, recognized by mAb 7F7. These results illustrate the heterogeneity of Bet v I, both with respect to the cross-reactive sites as well as to the backbone structure. This type of heterogeneity has possible implications for the use of monoclonal antibodies in allergen standardization.
Skewed pipelining for parallel simulink simulations (2010)

Modern automotive and aerospace embedded applications require very high-performance simulations that are able to produce new values every microsecond. Simulations must now rely on scalable performance of multi-core systems rather than faster clock frequencies. Novel parallelization techniques are needed to satisfy the industrial simulation demands that are essential for the development of safety-critical systems. Simulink formalism is the industrial de facto standard, but current state-of-the-art simulation and code generation techniques fail to fully exploit the parallelism in modern multi-core systems. However, closed-loop and dynamic system simulations are very difficult to parallelize because of the loop-carried dependencies. In this paper we introduce a novel skewed pipelining technique that overcomes these difficulties and allows loop-carried Simulink applications to be executed concurrently in multi-core systems. By delaying the forwarding of values for a few iterations, we can break some data dependencies and coarsen the granularity of programs. This improves the concurrency and reduces the high cost of inter-processor communication. Implementation studies to demonstrate the viability of our method on a commodity multi-core system with 2, 3, and 4 processors show a 1.72, 2.38, and 3.33 fold speedup over uniprocessor execution.
Mechanisms of Immunomodulation in Human Glioblastoma (2011)

Glioblastoma multiforme (GBM), WHO grade IV astrocytoma, is the most dramatic primary brain cancer with a very poor prognosis due to inevitable disease recurrence. Less than 10% of GBM patients are still alive 5 years after diagnosis despite a multimodal treatment with surgical resection of the tumor, radiation therapy and chemotherapy. Cellular immunotherapy in gliomas, one of the promising new therapies, has shown convincing results in some patients with induction of antitumor immune responses and prolonged survival. In particular, several patients treated with dendritic cell vaccinations have demonstrated systemic antigen-specific cytotoxicity and intratumor infiltration of cytotoxic T cells. However, this is not always correlated with clinical improvement because GBM cells have multiple mechanisms that lead to suppression of the patient's antitumor immune responses. This article will focus on some aspects of the systemic immunosuppression observed in GBM patients as well as the multiple mechanisms of local immunoresistance developed by GBM.
A primary adenosquamous carcinoma of the liver with an elevated level of serum squamous cell carcinoma related antigen. (1997)

A case of primary adenosquamous carcinoma of the liver with an elevated level of serum squamous cell carcinoma related antigen is herein reported. Various hypotheses on the pathogenesis of adenosquamous carcinoma of the liver have been set forth previously, however there is still no widely accepted theory because of the absence of any sufficient evidence. The postoperative transition of serum squamous cell carcinoma related antigen and the immunohistochemical findings using anti-involucrin antigen in this case support the hypothesis that the squamous cell carcinoma component arises as a result of the metaplastic transformation of adenocarcinoma cells.
The Effect of Dextran on the Lysability of Ex Vivo Thrombi (1975)

The lysability was determined of thrombi formed in Chandler tubes before and after infusion of 500 ml dextran 70 to patients undergoing cholecystectomy. 125I-labelled fibrinogen was given the day before operation. Following incubation of the thrombi formed in plasmin, radioactivity remaining in the thrombi and released to the supernatant was determined, as well as fibrinolytic degradation products in the supernatant, using an immunoelectrophoretic method. The dextran infusion was found to increase the radioactivity released from the thrombi to the supernatant from 15.5 plus or minus 7.6% to a maximum of 27.3 plus or minus 8.2% four hours after the infusion (P less than 0.001). A corresponding significant rise of the FDP concentration in the supernatant from 16.8 mug/ml to 44.1 mug/ml was found at the same time. After 24 hours the radioactivity had returned to initial values. The results indicate that dextran infused into patients during surgery increases the lysability of thrombi. It is suggested that this finding at least partly explains the antithrombotic effect of dextran.
Cardiomyopathy and heart transplantation in children (2002)

Cardiac transplantation has become a standard therapeutic option for certain disorders in which poor cardiac output without other surgical options exists in the face of maximized medical therapy. The most common disorder requiring transplantation is dilated cardiomyopathy, although other forms of cardiomyopathy (ie, restrictive cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy, and hypertrophic cardiomyopathy with poor ventricular function) may require transplantation as well. In this review, the current indications and outcomes of heart transplantation in patients with cardiomyopathy are discussed.
Abstract 17179: Tissue Factor Pathway Inhibitor Regulates Vascular Patterning in the Developing Zebrafish (2011)

Background: The tissue factor pathway regulates vascular structure in the adult through regulation of thrombin generation and signaling. Deletion of tissue factor pathway inhibitor (TFPI) in the mouse results in early intrauterine lethality, precluding study of vascular development. In addition, the carboxyl terminus of TFPI may have a TF-independent effect on vascular structure. We sought to determine the role of TFPI and its carboxyl terminus in vascular development of zebrafish. Methods and results: TFPI mRNA localization studies demonstrated expression in the developing kidney, gut, and vasculature of the zebrafish. We further assessed the role of TFPI in zebrafish angiogenesis, by injecting translational and splice-inhibiting morpholino (MO) oligonucleotides directed against zebrafish TFPI mRNA into embryos from the double transgenic zebrafish Tg(Fli1GFP); Tg(GATA1dsRed) expressing GFP in vascular endothelium and dsRed in erythroid cells. Knockdown of TFPI protein expression was subsequently confirmed by immunoblotting. In a dose-dependent manner, multiple non-overlapping MOs targeting the translation initiation site of TFPI independently and synergistically led to the formation of abnormally targeted intersegmental arteries which crossed somite boundaries by 48 hours post fertilization (hpf). Additionally, a plethoric caudal vein plexus with increased honeycombing was present by 24 hpf. This latter aspect of the phenotype was most striking after a MO targeted against a splice site involving the Kunitz 3 and carboxyl terminus domains of zebrafish TFPI was injected alone. Conclusions: TFPI is expressed during zebrafish development. Morpholino knockdown of TFPI expression alters both arterial and venous patterning in the developing zebrafish, indicating a fundamental role for TFPI in targeting of newly-formed blood vessels. Moreover, different domains of the TFPI protein may preferentially act on distinct vascular networks.
Conférence de Mlle Magali Boisnard (1910)

Boisnard Magali, Klein Henri. Conférence de Mlle Magali Boisnard. In: Les Feuillets d'El-Djezaïr, volume 1, 1910. Le Comité du Vieil Alger. pp. 30-33.
Deconvolution of Wireline Formation Test Data (2009)

Abstract Robust methods of deconvolution have been available to the well testing industry recently. This paper investigates the viability of applying a deconvolution algorithm to mini-DST data. A mini-DST test is conducted with a wireline formation tester (WFT) equipped with straddle packers. The use of straddle packers enables an isolated interval from where production can be induced. A mini-DST is actually a small-scale well test with limited entry. The production rate history of a mini-DST has special features. Because the rate of mini-DST is measured close to the source at a downhole location, it is more accurate than measurement from a well test. However, the rate history consists of hundreds of short-term build-ups due to pump characteristics. Special procedures are adopted to address these rate characteristics. Both synthetic and field tests demonstrate that a deconvolution algorithm can be applied to mini-DST data. The application of deconvolution can enhance the radius of investigation. Because deconvolution yields non-unique results, a robust inversion requires at least two build-ups. The data sets selected for deconvolution should be consistent; otherwise, deconvolution will fail. This paper presents deconvolution results of mini-DST data. A deconvolution algorithm is developed to address the characteristics of production rate during a mini-DST test. A comparison study with other deconvolution software is conducted. It proves that deconvolution algorithms work well with mini-DST data.
Presenting Movement in a Computer-Based Dance Tutor (2003)

Abstract This article addresses how to present movement information to learners as part of a larger project on developing a nonconventional computational system that teaches ballet. The requirements of such a system are first described, and then discoveries regarding the first requirement, presenting movement to a user, are discussed. Background research regarding how people learn movement, hypotheses concerning presenting movement with computer animation versus videotape, and an experiment testing those hypotheses are presented. The experiment required individuals to perform movements after viewing them in one of the formats. Each participant viewed a movement sequence multiple times and then was evaluated on his or her performance of that movement by two expert judges. Animations resulted in higher performance ratings for individuals with some previous dance experience. Format did not affect performance for other learners. This result implies that domain knowledge interacts with presentation format in learning ballet. These results will influence the design and implementation of a computer-based dance tutor under development, and they point to several interesting research directions, including exploring the effects of multimodal sensory presentations and prior knowledge in learning movement.
Assessment of the optimization of affinity and specificity at protein–DNA interfaces (2009)

The biological functions of DNA-binding proteins often require that they interact with their targets with high affinity and/or high specificity. Here, we describe a computational method that estimates the extent of optimization for affinity and specificity of amino acids at a protein-DNA interface based on the crystal structure of the complex, by modeling the changes in binding-free energy associated with all individual amino acid and base substitutions at the interface. The extent to which residues are predicted to be optimal for specificity versus affinity varies within a given protein-DNA interface and between different complexes, and in many cases recapitulates previous experimental observations. The approach provides a complement to traditional methods of mutational analysis, and should be useful for rapidly formulating hypotheses about the roles of amino acid residues in protein-DNA interfaces.
Polarization controlled diffraction and near-field hot-spots in a quasiperiodic nanohole array in a gold film (2008)

Quasicrystal arrays show a rotationally symmetric diffraction pattern that can be oriented with the polarization. A comprehensive electromagnetic theory agrees with the observed transmission spectrum and diffraction, and it shows near-field hot-spots.
Implication of Ligand Choice on Surface Properties, Crystal Structure, and Magnetic Properties of Iron Nanoparticles (2013)

The behavior of iron nanoparticles is heavily influenced by their highly reactive surfaces. A better understanding of organic ligand/particle interactions must be achieved in order to synthesize iron nanoparticles with magnetic saturations ( σ sat ) equivalent to bulk iron. Even when synthesized using careful, air‐free chemistry techniques and ligands more weakly interacting than those often reported in the literature, the magnetic saturation of iron nanoparticles generally only approaches, but not equals, the magnetic saturation of bulk iron. Here, iron nanoparticles are synthesized using Schlenk line chemistry methods and two different weakly interacting ligands: 2,4‐pentanedione and hexaethylene glycol monododecylether. These particles have saturation magnetizations slightly lower than bulk iron, which is believed to be caused by interactions between the passivating ligands and the surface of the nanoparticles. Using X‐ray absorption fine structure studies, it is shown that oxidized species of iron exist at the nanoparticles’ surface and can be attributed to iron/ligand interaction. The percentage of oxidized species scales with the surface to volume ratio of the nanoparticles, and therefore appears limited to the nanoparticle surface. X‐ray absorption fine structure analysis also shows that the nanoparticles have an expanded crystalline lattice, which can further impact their magnetic properties.