gebhart/patrepeval huggingface dataset:
GATA-1 Forms Distinct Activating and Repressive Complexes in Erythroid Cells. (2004)

Abstract GATA-1 is a key transcription factor essential for the differentiation of the erythroid, megakaryocytic and eosinophilic lineages. GATA-1 functions in erythropoiesis involve lineage-specific gene activation and repression of early hematopoietic transcription programs. GATA-1 is known to interact with other transcription factors, such as FOG-1, TAL-1 and Sp1 and also with CBP/p300 and the SWI/SNF chromatin remodeling complex in vitro. Despite this information the molecular basis of its essential functions in erythropoiesis remains unclear. We show here that GATA-1 is mostly present in a high (> 670kDa) molecular weight complex that appears to be dynamic during erythroid differentiation. In order to characterize the GATA-1 complex(es) from erythroid cells, we employed an in vivo biotinylation tagging approach in mouse erythroleukemic (MEL) cells1. Briefly, this involved the fusion of a small (23aa) peptide tag to GATA-1 and its specific, efficient biotinylation by the bacterial BirA biotin ligase which is co-expressed with tagged GATA-1 in MEL cells. Nuclear extracts expressing biotinylated tagged GATA-1 were bound directly to streptavidin beads and co-purifying proteins were identified by mass spectrometry. In addition to the known GATA-1-interacting transcription factors FOG-1, TAL-1 and Ldb-1, we describe novel interactions with the essential hematopoietic transcription factor Gfi-1b and the chromatin remodeling complexes MeCP1 and ACF/WCRF. Significantly, GATA-1 interaction with the repressive MeCP1 complex requires FOG-1. We also show in erythroid cells that GATA-1, FOG-1 and MeCP1 are stably bound to repressed genes representing early hematopoietic (e.g. GATA-2) or alternative lineage-specific (e.g. eosinophilic) transcription programs, whereas the GATA-1/Gfi1b complex is bound to repressed genes involved in cell proliferation. In contrast, GATA-1 and TAL-1 are bound to the active erythroid-specific EKLF gene. Our findings on GATA-1 complexes provide novel insight as to the critical roles that GATA-1 plays in many aspects of erythropoiesis by revealing the GATA-1 partners in the execution of specific functions.
Self-assembled monolayers in organic electronics (2016)

Self-assembly is possibly the most effective and versatile strategy for surface functionalization. Self-assembled monolayers (SAMs) can be formed on (semi-)conductor and dielectric surfaces, and have been used in a variety of technological applications. This work aims to review the strategy behind the design and use of self-assembled monolayers in organic electronics, discuss the mechanism of interaction of SAMs in a microscopic device, and highlight the applications emerging from the integration of SAMs in an organic device. The possibility of performing surface chemistry tailoring with SAMs constitutes a versatile approach towards the tuning of the electronic and morphological properties of the interfaces relevant to the response of an organic electronic device. Functionalisation with SAMs is important not only for imparting stability to the device or enhancing its performance, as sought at the early stages of development of this field. SAM-functionalised organic devices give rise to completely new types of behavior that open unprecedented applications, such as ultra-sensitive label-free biosensors and SAM/organic transistors that can be used as robust experimental gauges for studying charge tunneling across SAMs.
Structure of gyroid mesophase formed by monodendrons with fluorinated alkyl tails (2007)

The structure of a three-dimensional mesophase has been studied by the methods of small-angle X-ray diffraction and reconstruction of electron-density maps of the cubic lattice. In the oriented samples based on monodendrons with partially fluorinated alkyl tails, this mesophase has been shown to coexist with a two-dimensional columnar phase through a wide temperature interval. Epitaxial relationships between (10) planes of the hexagonal lattice and (211) planes of the cubic lattices lead to the ten-point pattern of azimuthal intensity distribution for the first X-ray 211 reflection and to the six-point intensity distribution for the second 220 reflection. The observed 12-point pattern of the 220 reflection is due to the presence of twin “crystallites” of the three-dimensional phase, and their [110] axis is parallel to the axis of cylinders in the columnar phase. The reconstructed electron-density maps show that the regions with increased electron density, which are composed of fluorinated aliphatic tails, form a bicontinuous gyroid structure.
A Comprehensive Comparison of Normalization Methods for Loading Control and Variance Stabilization of Reverse-Phase Protein Array Data (2014)

Loading control (LC) and variance stabilization of reverse-phase protein array (RPPA) data have been challenging mainly due to the small number of proteins in an experiment and the lack of reliable inherent control markers. In this study, we compare eight different normalization methods for LC and variance stabilization. The invariant marker set concept was first applied to the normalization of high-throughput gene expression data. A set of “invariant” markers are selected to create a virtual reference sample. Then all the samples are normalized to the virtual reference. We propose a variant of this method in the context of RPPA data normalization and compare it with seven other normalization methods previously reported in the literature. The invariant marker set method performs well with respect to LC, variance stabilization and association with the immunohistochemistry/florescence in situ hybridization data for three key markers in breast tumor samples, while the other methods have inferior performance. The proposed method is a promising approach for improving the quality of RPPA data.
Results of combined complete removal of directly invaded organs with the stomach in patients with advanced gastric cancer. (2003)

In conclusion, our study suggested that complete removal of invaded organs simultaneously with gastrectomy can prolong postoperative survival of patients with gastric cancer directly invading adjacent organs.
A new family of cation-binding compounds: threo-.alpha.,.omega.-poly(cyclooxalkane)diyl (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new family of cation-binding compounds: threo-.alpha.,.omega.-poly(cyclooxalkane)diylWilliam J. Schultz, Margaret C. Etter, Alphonsus V. Pocius, and Samuel SmithCite this: J. Am. Chem. Soc. 1980, 102, 27, 7981–7982Publication Date (Print):December 1, 1980Publication History Published online1 May 2002Published inissue 1 December 1980https://doi.org/10.1021/ja00547a049Request reuse permissionsArticle Views150Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Uptake and Inactivation of Thrombin on Aortic Endothelium and Neo-Intima (1985)

The aim of this study was to investigate the uptake and inactivation of thrombin on aortic endothelium and neo-intima developing on vascular grafts in pigs and dogs. Thrombin, measured with a synthetic chromogenic substrate, was found on the grafts, particularly on grafts with an incompletely developed neo-intima. After incubation of grafts and aortic segments with thrombin in vitro, significantly more thrombin was taken up on the grafts as compared to aortic endothelium. In the presence of plasma, surface-bound thrombin was inactivated much faster on aortic endothelium than on neo-intima. If surfaces loaded with thrombin in vitro were incubated with a balanced salt solution the enzyme was inhibited much more slowly. Thrombin activity on the neo-intima may contribute to graft thrombosis.
Charles Bonnet Syndrome: An Early Marker for Dementia? (1996)

The results of the study indicate that patients diagnosed with Charles Bonnet Syndrome evidence neuropsychological changes commonly associated with the early stages of dementia. Therefore, in patients with impaired vision, the appearance of cognitive deficits, albeit subtle, occur with the onset of visual hallucinations. We propose that isolated visual hallucinations in the older adult may be an indication of the early stages of dementia.
Toxoplasma gondii Comprises Three Clonal Lineages: Correlation of Parasite Genotype with Human Disease (1995)

The population genetic structure of Toxoplasma gondii was determined by multilocus restriction fragment length polymorphism analysis at 6 loci in 106 independent isolates from humans and animals. Phylogenetic and statistical analyses indicated a highly unusual population structure consisting of 3 widespread clonal lineages. Extensively mixed genotypes were only apparent in 4 strains, which indicated that, while not separate species, sexual recombination between the 3 lineages is exceedingly rare in natural populations. T. gondii is a major cause of subclinical human infection and an important opportunistic pathogen that causes severe disease in immunocompromised patients. While strains from all 3 lineages were isolated from humans, the majority of human toxoplasmosis cases were associated with strains of a type II genotype. The correlation of specific clonal lineages with human toxoplasmosis has important implications for development of vaccines, drug treatments, and diagnostic protocols.
and mapping of isoform differences and disease-related mutations (2009)

The Na C ,K C -ATPase transforms the energy of ATP to the maintenance of steep electrochemical gradients for sodium and potassium across the plasma membrane. This activity is tissue specific, in particular due to variations in the expressions of the alpha subunit isoforms one through four. Several mutations in alpha2 and 3 have been identified that link the specific function of the Na C ,K C -ATPase to the pathophysiology of neurological diseases such as rapid-onset dystonia parkinsonism and familial hemiplegic migraine type 2. We show a mapping of the isoform differences and the diseaserelated mutations on the recently determined crystal structure of the pig renal Na C ,K C -ATPase and a structural comparison to Ca 2C -ATPase. Furthermore, we present new experimental data that address the role of a stretch of three conserved arginines near the C-terminus of the alpha subunit (Arg1003–Arg1005).
Adsorbate-adsorbate interactions and chemisorption at different coverage studied by accurate {\em ab initio} calculations: CO on transition metal surfaces (2005)

We use density functional theory (DFT) with the generalized gradient approximation (GGA) and our first-principles extrapolation method for accurate chemisorption energies {[Mason {\em et al.}, Phys. Rev. B {\bf 69}, 161401R (2004)]} to calculate the chemisorption energy for CO on a variety of transition metal surfaces for various adsorbate densities and patterns. We identify adsorbate through-space repulsion, bonding competition, and substrate-mediated electron delocalization as key factors determining preferred chemisorption patterns for different metal surfaces and adsorbate coverages. We discuss how the balance of these interactions, along with the inherent adsorption site preference on each metal surface, can explain observed CO adsorbate patterns at different coverages.
The complexes of copper with polyphosphates. (1960)

S o c ., 7 , 5 (1 9 5 8 ). 10
Preparation of standards for quality control of the measurement of erythrocyte deformability (filterability) (1988)

Measurements of blood rheology in clinical studies should incorporate a quality control programme and, for this purpose, we have studied three approaches to the preparation of an erythrocyte standard. Partial fixation of erythrocytes using 0.04% w/v formaldehyde at ambient temperature, followed by storage at 4°C, provided an erythrocyte suspension which gave stable 5 µm pore filtration values for up to 4 weeks. Incubation of erythrocytes with a monoclonal antibody (BRIC 14) to membrane Glycophorin A caused impairment of filterability which was maintained for up to 11 days. A cross-linked acrylic copolymer, comprising soft spheres of 5–8 µm diameter, was also developed as an erythrocyte substitute for filtration studies. This pilot study indicates the potential for development of an international reference standard for rheological studies.
Abstract: Virtual Rhinoplasty Becomes Reality: Intra-Operative Monitoring with 3D Photography (2016)

PURPOSE: Photography plays an important role in rhinoplasty yet is limited as a true anatomic reference. Three-dimensional photography is becoming increasingly recognized as a superior method for viewing and analyzing the facial contour. Understanding the complex anatomy and subtle changes inherent to rhinoplasty benefit from 3D photography and computer analysis. METHODS: Patients undergoing rhinoplasty had 3D photographs taken pre-operatively (n=16). A virtually rhinoplasty was simulated during the pre-operative consult (Canfield Vectra H1), and displayed with pre-operative 3D in the operating room for reference. Intra-operative 3D photographs were then captured at one or more of the following: 1. Dorsal hump reduction, 2. Tip modification, 3. Correction of septal deviation, and overlayed with baseline to visualize changes and highlight regions requiring further modification. Immediate post-operative 3D photographs were captured, and families were given the option to view the result. RESULTS: Interval 3D photographs were most useful to guide dorsal hump reduction and tip rotation. Post-operative 3D-photographs captured the result with minimal swelling. All families wanted to see the 3D photos after surgery and reported they found the experience positive, alleviating their concerns regarding the aesthetic outcome. CONCLUSION: 3D photography and simulation aligned aesthetic goals and expectations before surgery. Overlay between intra-operative photographs and the simulation highlighted adherence to previously defined aesthetic goals. All patients/families to date reported viewing the immediate 3D post-operative image as a positive experience. DISCLOSURE/FINANCIAL SUPPORT:None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript.
Radiation Characteristics of Glass Containing Gas Bubbles (2003)

In many materials processing and manufacturing situations such as steel, aluminum, ceramics, and glass, gas bubbles can form in liquid and solid phases. The presence of such bubbles affects the thermophysical properties and radiation characteristics of the two‐phase system and hence the transport phenomena. This paper presents a general formulation of the radiation characteristics of semitransparent media containing large gas bubbles (bubble radius is much larger than the wavelength of radiation). Sample calculations for the spectral absorption and extinction coefficients and single scattering albedo of soda–lime silicate glass containing bubbles are discussed. Particular attention is paid to the effect of the volumetric void fraction and the bubble size distribution. Results clearly show that the presence of bubbles strongly affects the radiation characteristics of the semitransparent media containing entrapped gas bubbles, particularly if bubbles, void fractions, and the spectral absorption coefficient of the continuous phase are small.
A comparative study of the modified Sauvé–Kapandji procedure for rheumatoid wrist with and without stabilization of the proximal ulnar stump (2010)

We compared the clinical and radiological results of the modified Sauvé-Kapandji procedure for 41 of 86 operated rheumatoid wrists with (n=22) and without (n=19) stabilization of the proximal ulnar stump with a slip of half the extensor carpi ulnaris tendon. Gender, age, and follow-up period were similar in the two groups. We found no difference clinically or on radiographs between the two groups other than better early postoperative pain relief in those stabilized. Stabilization of the proximal ulnar stump may not be necessary in the modified Sauvé-Kapandji procedure for rheumatoid wrists.
B7.1 EXPRESSION ENHANCES EFFECTIVE IL-12 MEDIATED ANTITUMOR IMMUNITY (1994)

Journal of Immunotherapy with Emphasis on Tumor Immunology: October 1994 - Volume 16 - Issue 3 - p 247
NMR comparative study of PbMg_1/3Nb_2/3O_3 and PbSc_1/2Nb_1/2O_3 local structure (2002)

The 93Nb and 45Sc NMR spectra in PbSc_1/2Nb_1/2O_3 (PSN) and PbMg_1/3Nb_2/3O_3 (PMN) disordered relaxor ferroelectrics at the temperature T > T_0 (T_0 is the temperature of the dielectric susceptibility maximum) have been studied. Spectra analysis was performed on the base both of the analytical description of NMR lines shapes, allowing for homogeneous and inhomogeneous broadening related to a random distribution of the electric field gradients and numerical Monte Carlo method taking into account electric field gradients originated from random distribution of Mg, Sc and Nb ions (which may be shifted or not) over B-type cation sites. The observed 1/2 -1/2 transition spectrum both of the 93Nb and 45Sc nuclei in the PSN was shown to contain a narrow (3-4 kHz) almost isotropic part and a broad strongly anisotropic part. These two components of NMR spectra are related to 1:1 Sc/Nb ordered and compositionally disordered regions of the crystal, respectively. It was shown that in the disordered regions Sc^3+, Nb^5+ and O^2- ions are shifted from their cubic lattice sites at one of three possible directions: <100>, <110> or <111>. In PMN the NMR spectrum of 93Nb contains practically only the broad component. The portion of unbroadened spectrum that may correspond to ideal 1:2 regions accounts only for 1-2 percent of the total integral intensity. No evidance was obtained about existence of the 1:1 regions in PMN. The NMR data demonstrate that in PMN the cubic symmetry at T > T_0 is locally broken due to ions shifts similar to that in disordered PSN. The values of the ion shifts were estimated in the point charges point dipoles approximation of the electric field gradients calculation both in the PSN and PMN.
Laparoscopic Ultrasonography-Assisted Retroperitoneal Lymph Node Sampling in Patients Evaluated for Stomach Cancer Recurrence (2008)

Precise localization of a small lymph node located deep in the abdomen can be readily performed by intraoperative LUS.
Thermodynamic properties of transition metal compounds and coordination complexes: II. The lattice energies of some compounds of the divalent metals Ca ‐ Zn (1962)

Abstract The lattice energies U of octahedrally coordinated Ca ‐ Zn compounds can be represented by an equation ‐ U = C + I ‐ n e Δ where C is a constant, I the ionization potential (I 1 + I 2 ) of the atom and Δ another constant that is numerically comparable to the spectroscopic ligandfield splitting factor while n e is the number of 3d electrons in e g antibonding orbitals. It is shown that deviations from the predictions of this equation can be explained by changes in coordination number or the occurrence of cation‐cation bonding. The correlation can be derived from the m.o. theory in a simple manner provided that the lattice energy of compounds of inert‐gas ions is linearly dependent on I.
Radiation effects in LiYF<sub>4</sub> (1980)

Radiation-induced defects in LiYF4 have been studied using optical and ESR techniques. A pi -polarised absorption band at 3.99 eV is identified as the (F2-) centre. An optical band at 3.70 eV has polarisation properties characteristic of dipoles oriented in the direction of Y3+-Y3+ pairs. This band is a candidate for the F centre. Other optical bands with pi -polarisation at 3.02 eV and with sigma polarisation at 2.29 eV and 2.88 eV were not identified. These optical bands occur in nominally pure samples and also in samples doped with 1%Pr3+ and Er3+.
Channel adaptive multiple access and intersymbol interference cancellation techniques for TDD-mode UMTS receivers (2001)

This paper presents a comparison of simulation results for various time division duplex (TDD) UMTS receiver architectures. Uplink and downlink simulations are performed over frequency-selective time varying channels. Results indicate that in practice, satisfactory performance cannot be obtained using fixed branch receiver architectures. To overcome this limitation, a reconfigurable blind adaptive linear minimum mean square error (LMMSE) receiver is proposed to simultaneously track channel variations and mitigate the effects of multiple access interference and intersymbol interference. This new method is compared with the standard correlator, RAKE receiver and chip level equalisation techniques. System performance is studied in terms of uncoded bit error rate for low and medium levels of RMS delay spread. Simulations demonstrate that adaptive branch and parameter selection greatly reduces the interference floor in multi-user CDMA systems. More specifically, the proposed reconfigurable blind adaptive LMMSE is shown to offer competitive results at low relative complexity. This approach can be used to improve the performance and capacity of TDD mode UMTS networks
Management of mammillary fistulae. (1991)

Mammillary fistulae develop between the lactiferous ducts of the breast and areolar skin. Over a 14-year period 41 fistulae were treated in 36 patients (34 women, 2 men). In 24 women at least one subareolar abscess (mean 2.5) had been incised and drained previously. Fourteen fistulae developed after discharge of an inflammatory mass and three after surgical biopsy. Twelve women underwent 13 fistulectomies, two of which required reoperation. The remaining 24 patients with complicated fistulae (n = 28) had previously undergone multiple surgical procedures; 12 patients had 13 fistulae treated by total duct excision and primary closure without antibiotic cover and six fistulae required reoperation. Fifteen fistulae in 12 women were treated by duct excision with either primary closure under antibiotic cover (n = 7) or packing with healing by granulation (n = 8) and only one recurred (P less than 0.05). Operations for mammillary fistulae should be treated as contaminated procedures. In simple cases where no previous surgery has taken place, fistulectomy is appropriate. In complicated cases, treatment should be duct excision with the wound either closed primarily under antibiotic cover or left open to heal by secondary intention.
Role of interleukin 1-beta in meningeal inflammation (1989)

RAMILO, OCTAVIO MD; MUSTAFA, MAHMOUD M. MD; SÁEZ-LLORENS, XAVIER MD; MERTSOLA, JUSSI MD; OHKAWARA, SUSUMU MD; YOSHINAGA, MASARU MD; HANSEN, ERIC J. PHD; MCCRACKEN, GEORGE H. JR. MD Author Information