gebhart/patrepeval huggingface dataset:
Reprecipitation synthesis of luminescent CH<sub>3</sub>NH<sub>3</sub>PbBr<sub>3</sub>/NaNO<sub>3</sub> nanocomposites with enhanced stability (2016)

A facile one-step method was developed to fabricate luminescent CH<sub>3</sub>NH<sub>3</sub>PbBr<sub>3</sub>/NaNO<sub>3</sub> nanocomposites. Due to the space localization and protection of the tight inorganic salt matrix, the nanocomposites show a longer PL lifetime and enhanced thermal, light, and solvent stability.
Milking of microalgae: Production and selective extraction of Beta-carotene in two-phase bioreactors (2003)

Actually, my travel to The Netherlands was my first trip abroad.My wife, Zahra, and children, Selva and Maryam joined me in this trip.It was very difficult for us to leave our family and relatives in Iran
THE INFLUENCE OF THE MOLECULAR MEAN FREE PATH ON THE PERFORMANCE OF HYDRODYNAMIC GAS LUBRICATED BEARINGS. Interim Report (1958)

A modified Reynolds equation is derived for gaslubricated hydrodynamic bearings operating under ''slip flow'' conditions. Closed analytical solutions are given for a Rayleigh-type step-bearing and an inclined plane slider bearing for the case of two-dimensional flow. The influence of the molecular mean free path on the performance of bearings of arbitrary form is obtained by means of a small parameter, perturbation technique. (auth)
Thymidylate synthase as a chemotherapeutic drug target: Where are we after fifty years? (2006)

AbstractCommentary to:A Proposed Clinical Test for Monitoring Fluoropyrimidine Therapy: Detection and Stability of Thymidylate Synthase Ternary ComplexesJ.R. Brody, E. Gallmeier, K. Yoshimura, T. Hucl, P. Kulesza, M.I. Canto, R.H. Hruban, R.D. Schulick and S.E. KernCancer Biology & Therapy; Volume 5, Issue 8http://www.landesbioscience.com/journals/cbt/article/2976
Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation (2020)

Adenosine diphosphate sensitivity for ROS production decreases in aged mouse gastrocnemius muscle fibres, although aged mice do not exhibit a difference in OCR. Denervation does not induce ADP insensitivity; however, insensitivity to ADP is induced in a model of oxidative stress. ADP insensitivity could contribute to muscle fatigue, and SS-31 may be the first drug capable of targeting this aging phenotype.
Deletion of the Prorenin Receptor from the Ureteric Bud Causes Renal Hypodysplasia (2013)

The role of the prorenin receptor (PRR) in the regulation of ureteric bud (UB) branching morphogenesis is unknown. Here, we investigated whether PRR acts specifically in the UB to regulate UB branching, kidney development and function. We demonstrate that embryonic (E) day E13.5 mouse metanephroi, isolated intact E11.5 UBs and cultured UB cells express PRR mRNA. To study its role in UB development, we conditionally ablated PRR in the developing UB (PRR (UB-/-)) using Hoxb7 (Cre) mice. On E12.5, PRR (UB-/-) mice had decreased UB branching and increased UB cell apoptosis. These defects were associated with decreased expression of Ret, Wnt11, Etv4/Etv5, and reduced phosphorylation of Erk1/2 in the UB. On E18.5, mutants had marked kidney hypoplasia, widespread apoptosis of medullary collecting duct cells and decreased expression of Foxi1, AE1 and H(+)-ATPase α4 mRNA. Ultimately, they developed occasional small cysts in medullary collecting ducts and had decreased nephron number. To test the functional consequences of these alterations, we determined the ability of PRR (UB-/-) mice to acidify and concentrate the urine on postnatal (P) day P30. PRR (UB-/-) mice were polyuric, had lower urine osmolality and a higher urine pH following 48 hours of acidic loading with NH4Cl. Taken together, these data show that PRR present in the UB epithelia performs essential functions during UB branching morphogenesis and collecting duct development via control of Ret/Wnt11 pathway gene expression, UB cell survival, activation of Erk1/2, terminal differentiation and function of collecting duct cells needed for maintaining adequate water and acid-base homeostasis. We propose that mutations in PRR could possibly cause renal hypodysplasia and renal tubular acidosis in humans.
학술논문의 DOI번호 생성을 위한 방법 및 지원시스템 연구 (2011)

현재 KISTI에서 사용하고 있는 DOI번호 부여규칙은 일반적인 저널의 형식에 근거하여 부여할 수 있게 되어 있다. 하지만, 논문의 디지털화가 진행되면서 그리고 출판형태가 다변화되면서 기존의 DOI부여규칙과는 다른 DOI번호부여규칙의 필요성이 제기되고 있다. 따라서 과학 분야 논문 중 신속한 유통을 위해 인쇄저널로 출판되기 전에 미리 웹상에서 서비스되고 있는 저널인 경우 새로운 DOI번호 부여규칙 체계를 마련하여 시스템을 통해 학회나 기관이 적용할 수 있도록 했으며, 식별자로서 DOI번호의 중복을 방지하기 위한 지원시스템도 구현하였다. 외국의 DOI번호 부여 방식사례를 통해 새로운 DOI 부여규칙방안을 제시하였고 학회나 기관이 시스템을 통해 직접 DOI번호를 생성하고 중복 여부를 확인할 수 있도록 지원시스템을 연구하고 구현하였다.
Automatic Determination of the Optimum Generic Sensor Model Based on Genetic Algorithm Concepts (2005)

Generic sensor models (GSMs) are comprehensive mathematical models by which different geometric structures of satellite images could be modeled in order to establish the connection between image and object spaces. Nevertheless, as they are mathematical models, rather than physical models, it is difficult to determine which term and order of GSMs can provide the best result. Therefore, conventional solutions need an expert operator to try different terms and orders for the best solution of GSMs or to find the best trade-off, which is a complex and time consuming process. Moreover, conventional solutions for automatic determination of the optimum GSM parameters are not practically efficient and instead of going towards the global optimum, frequently get trapped in some local optima. In this paper we propose a novel methodology which automatically determines the optimum GSM’s terms and orders based on genetic algorithm concepts. Extensive evaluations carried out on a wide range of different optical satellite images demonstrate the high potentials of the proposed strategy.
Manifestations of intense noise stimulation on spontaneous otoacoustic emission and threshold microstructure: Experiment and model (1992)

Comparison between changes that occur simultaneously on spontaneous otoacoustic emissions (SOAEs) and on other cochlear origin phenomena can contribute to the understanding of cochlear micromechanical activity. The temporary changes that arise after short noise exposure are investigated in the following paper. The effects of noise exposure on the threshold microstructure near an SOAE and on the amplitude and frequency of the SOAE were measured. These experimental results indicate the following: (1) exposure to wideband noise for a short time causes a temporary reduction in the SOAE frequency and amplitude, and alters reversibly the threshold microstructure in the vicinity of the SOAE. The difference between the minimum and maximum in the threshold microstructure is reduced, and the frequency that yields the minimum threshold decreases; (2) the threshold at the SOAE frequency is most sensitive to noise exposure; (3) intense stimulation causes a relatively small increase, or even a decrease, in threshold at frequencies near the SOAE. The experimental results are interpreted in terms of a nonlinear transmission line model which includes nonlinear amplifiers. The effect of the noise exposure is modeled by reduction in the cochlear partition amplification term. Most of the experimental results are predicted by this model.
Potential mechanisms of mitochondrial cytochrome‐C release during apoptosis (1999)

Cytochrome-c release from the intermembrane space of mitochondria to the cytoplasm is a critical signaling event during many forms of apoptotic cell death. Due to the widespread involvement of apoptosis in pathobiology, this mitochondrial event is a logical target for the development of new therapeutic approaches to numerous diseases. Currently impeding such a development is our lack of understanding of the mechanism by which release of this component of the electron transport chain occurs in response to the wide variety of agents known to induce apoptosis. Release induced by the membrane permeability transition (a permeability change at the inner mitochondrial membrane) likely results from mitochondrial swelling, consequent rupture of the outer mitochondrial membrane, and nonspecific release of intermembrane space contents. An alternative mode of release may include the induction of a specific permeability change at the outer mitochondrial membrane. These two mechanisms present distinct molecular targets for drug development. Drug Dev. Res. 46:18–25, 1999. © 1999 Wiley-Liss, Inc.
ChemInform Abstract: Efficient Synthesis of Functionalized 6‐Arylsalicylates via Microwave‐Promoted Suzuki Cross‐Coupling Reaction. (2014)

Abstract The two‐step procedure gives access to the title compounds starting from iodo salicylate (I) and a broad variety of arylboronic acids within a very short time and good to excellent yields.
Studies on the mechanism of expression of secreted fibrinogen on the surface of activated human platelets (1989)

Affinity purified anti-fibrinogen (anti-Fg) Fab fragments were used to study the mechanism of expression of alpha-granule fibrinogen on activated platelets. Low amounts of the radiolabeled anti-Fg Fab bound to unstimulated or adenosine diphosphate (ADP)-stimulated cells. They readily bound to platelets stimulated with collagen, alpha-thrombin or gamma-thrombin in the presence of divalent cations. At 1 n mol/L alpha- thrombin or 25 nmol/L gamma-thrombin, platelet fibrinogen was expressed on the surface of the cells notwithstanding the presence of AP-2, a monoclonal antibody to the glycoprotein (GP) IIb-IIIa complex, or the synthetic peptides Arg-Gly-Asp-Ser and gamma 400–411, all substances that prevented the binding of plasma fibrinogen to platelets. These results suggest that platelet fibrinogen may interact with its receptors during its translocation from the alpha-granules to the plasma membrane and, thus, not occupy the same sites as those available for plasma fibrinogen on the surface of the cell. Furthermore, we found that platelet fibrinogen was expressed on the thrombin-stimulated platelets of a Glanzmann's thrombasthenia variant that failed to bind plasma fibrinogen. Normal platelets stimulated with 5 nmol/L alpha- thrombin bound increased amounts of the anti-fg Fab, the additional expression being inhibited by the anti-GP IIb-IIIa monoclonal antibody or by Gly-Pro-Arg-Pro, an inhibitor of fibrin polymer formation. This suggests that rebinding to externally located GP IIb-IIIa complexes becomes important once fibrin is formed.
Bottom-up Object Detection by Grouping Extreme and Center Points (2019)

With the advent of deep learning, object detection drifted from a bottom-up to a top-down recognition problem. State of the art algorithms enumerate a near-exhaustive list of object locations and classify each into: object or not. In this paper, we show that bottom-up approaches still perform competitively. We detect four extreme points (top-most, left-most, bottom-most, right-most) and one center point of objects using a standard keypoint estimation network. We group the five keypoints into a bounding box if they are geometrically aligned. Object detection is then a purely appearance-based keypoint estimation problem, without region classification or implicit feature learning. The proposed method performs on-par with the state-of-the-art region based detection methods, with a bounding box AP of 43.2% on COCO test-dev. In addition, our estimated extreme points directly span a coarse octagonal mask, with a COCO Mask AP of 18.9%, much better than the Mask AP of vanilla bounding boxes. Extreme point guided segmentation further improves this to 34.6% Mask AP.
Synthesis of<i>S</i>-nitrosoglutathione-alginate for prolonged delivery of nitric oxide in intestines (2015)

S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evaluated for oral delivery to treat Crohn's disease. This new compound was prepared using a two-step procedure involving (I) linkage of reduced glutathione to alginate and (II) post-nitrosation with sodium nitrite (NaNO<sub>2</sub>). The amount of linked thiol moieties for the possible nitrosation was calculated using Ellman's method, and the amount of NO abducted on the polymer was calculated using the Griess-Saville method. An ex vivo model (i.e. Ussing chamber) was used to investigate the permeation of this new NO-donor across the rat intestinal barrier. We obtained polymers with different numbers of abducted NOs (174 ± 21 μmol/g for SNA F1 and 468 ± 23 μmol/g for SNA F2) depending on the procedure used for nitrosation. In the ex vivo studies in the Ussing chamber, SNA F2 exhibited a sustained release for at least 10 h. The effect of pH on the stability of the new compound was also investigated, and the new compound was more stable at a mildly basic pH of 8.4 where 73% remained after 1 week. However, only 50% remained after 1 week at an acidic pH of 1.2. In the cytotoxicity studies (Caco2), this compound was nontoxic at concentrations of less than 200 μM.
Multicategory Prediction of Multifactorial Diseases Through Risk Factor Fusion and Rank-Sum Selection (2005)

A generalized strategy is developed to predict the occurrence of a multicategory-multifactorial disease from a set of medical risk factors that are most often used to screen patients for the disease. The prediction problem is formulated as an M-class classification problem. The strategy employs fusion to combine risk factors into a single feature vector, normalization to fuse risk factors which have different formats and ranges, rank-sum ordering for feature selection, discrete Karhunen-Loeve transform-based transformation to facilitate parametric classifier development, and the design of parametric classifiers. Two methods, which differ on how the features are selected, are developed. In the first method, features are selected from a set consisting of linear combinations of all risk factors. In the second method, the features are linear combinations of a preselected subset of the risk factors. The methods are applied to predict the occurrence of Alzheimer's disease (AD) into three classes: Probable-AD, Possible-AD, and Uncertain. It is shown that a classification accuracy of over 71% can be obtained. This result is quite encouraging given that AD is very difficult to clinically diagnose. Higher classification accuracies can be expected for diseases that are not as complex to diagnose as AD. Most importantly, it is concluded that the generalized strategy can not only be applied to the multicategory-multifactorial disease prediction problem but also to other multiclass pattern recognition problems involving diverse information collected from different sources.
Apparatus (1951)

H. W. Hodgson, W. Angel and J. H. Glover, Analyst, 1951, 76, 379 DOI: 10.1039/AN9517600379
Cross-coupled MZI configuration for wavelengthselective switching (1999)

A novel optical device for wavelength selective switching is proposed. The device is based on a cross-coupled MZI (CCMZI) with wavelength-dependent cross-coupling. The analysis is based on mode propagation theory. SiO2/Si is presently the most promising technology for realising this kind of device.
Guest Editors' Introduction: What Does Nietzsche Mean for Contemporary Politics and Political Thought? (2008)

Over the last twenty years or so Nietzsche's significance for political thought has become the single most hotly contested area of Nietzsche research, especially in the English-speaking world: Is Nietzsche a political thinker at all?or an antipolitical philosopher of values and culture? Is he an aristocratic political thinker who damns democracy as an expression of modern nihilism?or can his thought, especially his thought on the Greek agon, be appropriated for contemporary democratic theory? These and other ongoing controversies attest to the profoundly ambivalent and controversial nature of Nietzsche's legacy for political thought. In this issue, we add the question of Nietzsche's actuality: What does Nietzsche mean for contemporary politics and political thought? Two significant events dedicated to Nietzsche and politics were organized in 2007: the Sixteenth International Conference of the Friedrich Nietzsche Society was held at the University of Leiden in the Netherlands in March, followed shortly, thereafter by a small conference at the University of Richmond. Four articles focused on Nietzsche and contemporary politics and drawn from these events appear in this special issue. Additional essays will soon appear in a volume titled Nietzsche, Power, and Politics.1 One reason for the explosion of literature on Nietzsche and the political in recent years is the perception that he offers a wealth of resources for rethinking key political concepts, theories, and events in a rapidly changing world. This was not always so. In the wake of World War II, Nietzsche was largely considered to be a critic of modernity with nothing constructive to offer political thought, capitulating instead to a blind, irrational voluntarism. But the great polarizations of the twentieth century, its world wars and Cold War, have now given way to a present that is wrestling with terrorist threats, preemptive strikes on the part of a single hyperpower, issues of globalization, environmental crises, andmulticul turalism. If the questions of the last century were posed between two poles, the questions of the present revolve around only one: What is it to become one (world, market, Europe, democracy, hyperpower...)? In this context, Nietzsche
Report of an Inspection Tour: To Make the People Strong (1950)

"Report of an Inspection Tour: To Make the People Strong." The Journal of Higher Education, 21(5), pp. 277–278
Mechanism of Ruthenium-Catalyzed Olefin Metathesis Reactions from a Theoretical Perspective (2002)

This paper presents a density functional theory study of the ruthenium-catalyzed olefin metathesis reactions. The ligand binding energy has been calculated in the first generation of Grubbs-type (PCy3)2Cl2Ru=CHPh (pre)catalyst, as well as in the heteroleptic (pre)catalytic systems in which a N-heterocyclic carbene, NHC, ligand substitutes a single phosphine. In agreement with experiments PCy3 coordinates more strongly to Ru in the heteroleptic (pre)catalysts than in the Grubbs-type (pre)catalyst. Moreover, ethene coordination and insertion into the Ru-alkylidene bond in the above-mentioned systems, as well as in the Hofmann type catalytic system with a cis-coordinated phosphane ligand, has been studied. The calculated insertion barrier for the NHC systems are lower than that of the (PCy3)2Cl2Ru=CHPh system. This is consistent with the higher activity experimentally observed for the NHC-based system.
Multi-media document representation and retrieval (1991)

Article Free Access Share on Multi-media document representation and retrieval Authors: Esen Ozkarahan School of Business, Penn State University, Erie, PA School of Business, Penn State University, Erie, PAView Profile , Fazli Can System Analysis Dept., Miami University, Oxford, OH System Analysis Dept., Miami University, Oxford, OHView Profile Authors Info & Claims CSC '91: Proceedings of the 19th annual conference on Computer ScienceApril 1991 Pages 420–429https://doi.org/10.1145/327164.327328Published:01 April 1991Publication History 1citation452DownloadsMetricsTotal Citations1Total Downloads452Last 12 Months4Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Radioreceptor assay for the determination of alpha 1-adrenoceptor-binding material in rat plasma following single oral administration of naftopidil. (1990)

Naftopidil could be characterized by receptor binding studies as an alpha 1-adrenergic antagonist with a binding affinity constant (Ki) of 58.3 nmol/l. both enantiomers of naftopidil revealed similar values, indicating no stereoselective inhibition of 3H-prazosin-binding. An alpha 1-adrenergic radiorecptor assay (RRA) was developed to determine receptor-binding material (parent compound and active metabolites) in the plasma of rats following single oral administration of naftopidil (50 mg/kg). The results indicate a rapid absorption. At the first sampling time (0.5 h) maximum concentration of receptor-binding material was measured. Terminal half-life was calculated with 16.7 h.
Long-Term Frequency Stability of the Rb87 Maser (1975)

A description of a compact Rb87 maser approximately 20 cm in diameter and 30 cm in length is given and the features of the principal components are discussed. The fractional frequency fluctuations (Allan variance) are less than 5 × 10-13 for averaging times between 1 and 103 s. The effects of various parameters on the maser frequency are investigated experimentally and compared to theoretical predictions obtained from the maser frequency equation.
A Review on Shape Engineering and Design Parameterization in Reverse Engineering (2012)

On the other hand, shape engineering and design parameterization aims at creating fully parametric solid models from scanned data points and exporting them into mainstream www.intechopen.comReverse Engineering -Recent Advances and Applications 162 CAD packages that support part re-engineering, feature-based NC toolpath generations, and technical data package preparation.Although, converting data points into NURB surface models has been automated, creating parametric solid models from data points cannot and will not be fully automated.This is because that, despite technical challenges in implementation, the original design intent embedded in the data points must be recovered and realized in the parametric solid model.Modeling decisions have to be made by the designer in order to recover the original design intents.However, designers must be relieved from dealing with tedious point data manipulations and primitive geometric entity constructions.Therefore, the ideal scenario is having software tools that take care of labor intensive tasks, such as managing point cloud, triangulation, etc., in an automated fashion; and offer adequate capabilities to allow designers to interactively recover design intents.Such an ideal scenario has been investigated for many years.After these many years, what can be done with the technology and tools developed at this point?Many technical articles already address auto surfacing.In this chapter, in addition to auto surfacing, we will focus on solid modeling and design parameterization.We will present a brief review and technical advancement in 3D shape engineering and design parameterization for reverse engineering, in which discrete point clouds are converted into feature-based parametric solid models.Numerous efforts have been devoted to developing technology that automatically creates NURB surface models from point clouds.Only very recently, the development was extended to support parametric solid modeling that allows significant expansion on the scope of engineering assignments.In this chapter, underlying technology that enables such advancement in 3D shape engineering and design parameterization is presented.Major commercial software that offers such capabilities is evaluated using practical examples.Observations are presented to conclude this study.Next, we will present a more precise discussion on design parameterization to set the tone for later discussion in this chapter.www.intechopen.