gebhart/patrepeval huggingface dataset:
Sn/C Composite Anodes for Li-Ion Batteries (2004)

Composites of Sn/C were synthesized by infiltrating tetraethyltin into mechanically milled polystyrene resin powder. Heat-treatment of the precursor in Ar atmosphere at 600°C results in crystalline tin and amorphous carbon. The resultant composite exhibits a capacity of 480 mAh/g with good capacity retention (0.15% loss/cycle). Transmission electron microscopy analysis indicates nanocrystalline spherical tin particles embedded in large carbon particles to The embedment of nanocrystalline tin within carbon appears to be the main reason for the good cyclability suggesting the excellent potential of these Sn/C based composites for use as alternative anodes for lithium-ion batteries. © 2004 The Electrochemical Society. All rights reserved.
Effect of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (CV-2619) on microsomal lipid peroxidation. (1986)

6-(10-Hydroxydecyl)-2, 3-dimethoxy-5-methyl-1, 4-benzoquinone (CV-2619) and related compounds (the corresponding hydroquinone and hydroquinone monosulfate forms) inhibited lipid peroxidation, especially that initiated with ferrous ion in microsomes of rat liver and canine brain. The fact that CV-2619 inhibited the Fe2+ -dependent peroxidation of the membrane lipid in microsomes and linolenic acid indicated that CV-2619 itself possesses antioxidant activity, like its hydroquinone form. However, CV-2619 barely inhibited lipid peroxidation in aged membranes and did not quench hydroxy radicals. It showed some stimulation of peroxide quenching systems, such as horserdish peroxidase and rat liver cytosomal peroxidation-inhibiting protein. These results suggest that CV-2619 mainly inhibits the initial steps of lipid peroxidation.
Interactions of Seleted <i>Glycine soja</i> Sieb. & Zucc. Genetypes with Fast‐ and Slow‐Growing Soybean Rhizobia<sup>1</sup> (1984)

Seven genotypes of Glycine soja Sieb. & Zucc. (wild soybean) weree xaminedfo r effectiveness of N 2 ‐fixing symbiosesw ith fastand slow‐growing soybean rhizobia. Some genotypes were identlfied whichd emonstrated ifferential effectiveness with the two rhlzobia groups, while other lines had no apparent preference. Two genotypes with opposite preferences were tested with six strains of each rhizobia group. Glycine soja PI 342434 formed very effective symbioses with the slow growers, fixing over three times as much N with this group of strains as with the fastgrowing strains. Conversely, PI 468397 formed the most effective symbioses with the fast growers, fixing about three times as much N as with the slow growers. The demonstration of greater symbiotic effectiveness with the fast‐growing rather than the slowgrowing rhizobia has not previously been reported in Glycine species. PI 468397 was the genotype from which one of the fastgrowings trains was originally isolated. Thus, differential rhizobia group (fast or slow) interactions found in G. soja genotypes indicate that G. soja possesses a greater diversity of reaction to the two rhizobia groups for this characteristic than common North American G. max genotypes.
ESTIMATION OF OOP FROM CONDITIONAL PROBABILITIES OF AIRBAG FIRE-TIMES AND VEHICLE RESPONSE (1998)

The airbag can fire at any given time during a crash. To qualitatively and quantitatively address the probabilistic nature of the airbag fire-time as a result of a crash, a statistical data based model was used. Two models were constructed: one was based on rigid barrier impacts and the other used offset deformable barrier impacts. These models were developed previously and some of the preliminary results were presented at the 1998 SAE conference in Detroit. Since that time the models have been refined by inclusion of additional data, and the results of the refined models were compared to the results from the previously constructed models. The models were used to address the effects of raising the threshold and the risks of an occupant contacting the airbag module as a result of late firing. Although the individual numerical values have changed, the indicated general trends remain the same. Raising the threshold may or may not decrease the number of occupants on the module, depending on the accuracy of National Automotive Sampling System/Crashworthiness Data System (NASS/CDS) and fire/no-fire as a function of velocity (c-censor), but it appears to reduce the effectiveness of the airbag when it does fire. The model indicates that decreasing the width of the c-censor, ie delta V from no fire to all fire, may be useful in reducing the number of occupants on the module without decreasing the effectiveness of the airbags. (A) For the covering abstract see IRRD E102514.
Isolation and characterization of lymphocyte mitogenic factor released <i>in vivo</i> during a cell-mediated immune reaction in the guinea pig. (1980)

By use of a guinea pig model of delayed hypersensitivity to horseradish peroxidase (HRPO), it has been possible to characterize the rate of release of lymphocyte mitogenic factor (MF) in vivo after i.p. challenge immune animals with antigen. MF is present in peritoneal fluid of immune guinea pigs 4 to 12 hr after i.p. challenge with HRPO, before 2 other lymphokines, lymphocyte-derived chemotactic factor for monocytes and macrophage migration-inhibitory factor, are released. The m.w. of MF generated in vivo and in vitro, as estimated by gel filtration, are similar, approximately 25,000. In vivo and in vitro MF are stable upon heating to 56 degrees C for 30 min. This observation that a mitogenic factor for lymphocytes is released early in vivo in a delayed hypersensitivity reaction gives support to the notion that its primary function in vivo may be to amplify cell-mediated immune reactions.
A common idiotype expressed on a murine anti-Sm monoclonal antibody and antibodies in SLE sera. (1987)

A rabbit anti-idiotypic antiserum made against a murine monoclonal anti-Sm autoantibody (Y2) was used in a solid-phase radioimmunoassay to investigate idiotypic cross-reactivity among anti-Sm antibodies present in sera from patients with systemic lupus erythematosus. Sera from 25 of 51 SLE patients (49%) containing anti-Sm antibodies were positive for this Y2 idiotype compared to only one of 22 normal human sera. Nine of 28 SLE patients (32%) whose sera were anti-Sm negative were also positive for the Y2 idiotype in low titre. Binding was not due to rheumatoid factor-like activity but was specific for the Y2 determinant and could be eliminated by absorption with Y2 monoclonal antibodies. The anti-idiotypic antibody blocked the ability of 12 of 25 anti-Sm positive lupus sera to bind Sm. Conversely, Sm antigen inhibited the binding of anti-idiotypic antibody in nine of 12 lupus sera.
Reversible covalent inhibition of papain by a peptide nitrile. Carbon-13 NMR evidence for a thioimidate ester adduct (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible covalent inhibition of papain by a peptide nitrile. Carbon-13 NMR evidence for a thioimidate ester adductJoseph B. Moon, Robert S. Coleman, and Robert P. HanzlikCite this: J. Am. Chem. Soc. 1986, 108, 6, 1350–1351Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/ja00266a066https://doi.org/10.1021/ja00266a066research-articleACS PublicationsRequest reuse permissionsArticle Views514Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Treatment of an Osseous Lesion Associated With a Severe Palato‐Radicular Groove: A Case Report (1992)

This is a case report that describes the management of a severe periodontal defect associated with a palato-radicular (palato-gingival) groove affecting the maxillary right lateral incisor of a 50 year-old male. The patient presented with pain, gingival swelling, and a 10 mm periodontal pocket on the distopalatal aspect of the right maxillary lateral incisor. The defect was initially treated by scaling and root planing. Several days later a flap was elevated, the osseous defect was debrided, and odontoplasty was performed to eliminate the groove. The root surface was treated with citric acid for 3 minutes, the osseous defect was filled with non-porous hydroxyapatite, a periodontal membrane was placed, and the flap was readapted to the tooth. Postoperative care included systemic (minocycline) and local (chlorhexidine) antimicrobial therapy. The membrane was removed 6 weeks postoperatively and 14 months postoperatively the gingiva appeared healthy; radiographs suggested substantial resolution of the osseous defect and about 7 mm of probing attachment gain was recorded. Further studies are necessary to determine which of the several modes of therapy used to treat this lesion are necessary for success.
Purification and some properties of serine hydroxymethyltransferase from <i>Trypanosoma cruzi</i> (2000)

A single form of serine hydroxymethyltransferase (SHMT) was detected in epimastigotes of Trypanosoma cruzi, in contrast to the three isoforms of the enzyme characterized from another trypanosomatid, Crithidia fasciculata [Capelluto D.G.S., Hellman U., Cazzulo J.J. & Cannata J.J.B. (1999) Mol. Biochem. Parasitol. 98, 187-201]. The T. cruzi SHMT was found to be highly unstable in crude extracts. In the presence of the cysteine proteinase inhibitors N-alpha-p-tosyl-L-lysine chloromethyl ketone and Ltrans-3-carboxyoxiran-2-carbonyl-L-leucylagmatine, however, the enzyme could be purified to homogeneity. Digitonin treatment of intact cells suggested that the enzyme is cytosolic. T. cruzi SHMT presents a monomeric structure shown by the apparent molecular masses of 69 kDa (native) and 55 kDa (subunit) determined by Sephadex G-200 gel filtration and SDS/PAGE, respectively. This is in contrast to the tetrameric SHMTs described in C. fasciculata and other eukaryotes. The enzyme was pyridoxal phosphate-dependent after L-cysteine and hydroxylamine treatments and it was strongly inhibited by the substrate analog folate, which was competitive towards tetrahydrofolate and noncompetitive towards L-serine. Partial sequencing of tryptic internal peptides of the enzyme indicate considerable similarity with other SHMTs, particularly from those of plant origin.
Reduced Intensity Compared to High Dose Conditioning for Allotransplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Comparative Clinical Analysis. (2004)

We evaluated the comparative safety and efficacy of stem cell transplantation using reduced intensity (RI) vs myeloablative (MA) conditioning for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) who underwent allogeneic hematopoietic stem cell transplantation (HSCT). Thirty two patients [18 males, median age 54 (range 19–69)] underwent a RI HSCT from January 2000- September 2003, and these were compared to 187 patients [93 males, median age 39 (range 18.4–60.3)] who received MA transplants between January 1990 – September 2003. Disease status in the 2 groups was similar, (AML in CR1: RI 38% vs MA 38%; CR2: 22% vs 15%; AML relapse: 13% vs 20% and MDS 28% vs 27%). Patients were eligible for RI if age >55 with HLA matched sibling donor (Sib) or >45 with unrelated bone marrow (BM) or umbilical cord blood (UCB) donor; extensive previous therapy including previous transplant or major co-morbidity. RI donors were Sib (n=17, 53%), unrelated UCB (n=14, 44%), or unrelated BM (n=1). MA donors were Sib (n=176, 94%) and UCB (n=11, 6 %), p<0.01. RI conditioning included an alkylator (busulfan (Bu) or cyclophosphamide (Cy), a nucleoside analogue (fludarabine or cladribine) and 200 cGy total body irradiation (TBI), while MA conditioning was Cy/TBI (1320 cGy) (n=177) or Bu/Cy (n=10). Median follow up is 1.7 years in RI recipients and 4.2 years in MA. Neutrophil engraftment was more rapid in the RI group (median =11.5 days vs 21 days) with 3% and 6% graft failure respectively in the RI and MA groups. The cumulative incidence of Grade III–IV acute graft versus host disease (GVHD) was 22%±14% in RI vs 12±4% after MA HSCT. The cumulative incidence of relapse or disease progression at 1 year was 31% after RI vs 22% after MA HSCT (p=0.06). Disease free survival (DFS) at 1 year was 31± 16% in RI and 37%± 7% in the MA group (p=0.14). Multivariate regression analysis showed that neither conditioning intensity (NST RR=1.4, p=0.14) nor donor choice (UCB RR 0.9, p=0.63) significantly altered DFS. More failures (relapse or death) followed transplant for AML in relapse (RR=1.5, p=0.05), recipient seropositive for CMV (RR1.4, p=0.03) and development of Grade III/IV GVHD (RR 1.9, p<0.01), with MDS having an outcome similar to AML in remission (RR 1.2,p=0.28). These data suggest that allografts for AML or MDS using RI conditioning, even for older patients or using unrelated UCB can yield satisfactory outcomes and extended DFS. Advances in GVHD management and new approaches for patients in relapse are needed to improve these outcomes.
Synthesis of enzymatically active firefly luciferase in yeast. (1988)

A recombinant plasmid containing a DNA segment complementary to the mRNA of the North American firefly, Photinus pyralis, luciferase was constructed and cloned into Escherichia coli. The cDNA was inserted into a yeast expression vector, AAH5, designed to express active luciferase under the control of the yeast alcohol dehydrogenase promoter. When introduced into the yeast, Saccharomyces cerevisiae, the resultant plasmid directed the synthesis of enzymatically active firefly luciferase, the activity of which was inhibited by antiserum raised against the purified firefly luciferase.
ChemInform Abstract: THE AROMATIZATION OF CYCLIC KETONES PART 2, NOVEL SYNTHESIS OF SUBSTITUTED DIHYDROXYBENZENES (1975)

Abstract 1,3‐Cyclohexandion (I) reagiert mit Acetanhydrid und Schwefelsäure unter Annahme von Zwischenstufen der Art (IIa)‐(IIc) zum Resorcindiacetat (IIIa), aus dem letztlich über 95% an Resorcin (IIIb) erhalten werden.
Average current space vector technique for the analysis of three-phase power factor correction circuits operating in discontinuous conduction mode (2003)

A novel space vector method which uses average currents over a switching cycle is proposed for the analysis of three-phase power factor correction circuits operating in discontinuous conduction mode. The technique is applied to a family of circuits with switches on the AC-side. The improvement in performance and wider flexibility of operation over DC-side circuits are shown.
Computational 3D Image Reconstruction of Curved Integral Imaging Using Convolution Property Between Periodic Functions (2013)

In this paper, an improved 3D image reconstruction using the convolution property between an elemental image and a periodic δ-function array in curved integral imaging is presented. To show the effectiveness of our scheme, we carry out some experiments and present the results.
Total variation based image restoration with free local constraints (2002)

A new total variation based approach was developed by Rudin, Osher and Fatemi (see Physica D., vol.60, p.259, 1992) to overcome the basic limitations of all smooth regularization algorithms. The TV-based technique use the L/sup 1/ norm of the magnitude of a gradient, thus making discontinuous and nonsmooth solutions possible. In TV image restoration, the solution is obtained by solving a time-dependent, nonlinear PDE on a manifold that satisfies the degradation constraints. In practical applications, one assumes a space-varying blurring kernel and signal-dependent (e.g. multiplicative) noise. The evolution part of the TV-based PDE turned out to be related to the curve shortening equation, but scaled by an inverse.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Inverse and Direct Dynamic Modeling of Gough–Stewart Robots (2004)

This paper presents closed-form solutions for the inverse and direct dynamic models of the Gough-Stewart parallel robot. The models are obtained in terms of the Cartesian dynamic model elements of the legs and of the Newton-Euler equation of the platform. The final form has an interesting and intuitive physical interpretation. The base inertial parameters of the robot, which constitute the minimum number of inertial parameters, are explicitly determined. The number of operations to compute the inverse and direct dynamic models are given.
Gamma Knife Radiosurgery for Trigeminal Neuralgia (1998)

Gamma knife radiosurgery is a minimally invasive technique to treat trigeminal neuralgia. It is associated with a low risk of facial paresthesias, an approximate 80% rate of significant pain relief, and a low recurrence rate in patients who initially attain complete relief. Longer-term evaluations are warranted.
ChemInform Abstract: SYNTHETIC STUDIES ON CEMBRANOLIDES. STEREOSELECTIVE SYNTHESIS OF EPOXY ESTER INTERMEDIATES (1984)

Abstract Propargylbromid (I) reagiert mit Methacrolein (II) über die Grignard‐ Verbindung zum Addukt (IIIa), aus dem das Derivat (IIIb) hergestellt und zu (IIIc) und (IIId) carboxyliert wird.
Bacterial Genome Annotation (2012)

Annotation of prokaryotic sequences can be separated into structural and functional annotation. Structural annotation is dependent on algorithmic interrogation of experimental evidence to discover the physical characteristics of a gene. This is done in an effort to construct accurate gene models, so understanding function or evolution of genes among organisms is not impeded. Functional annotation is dependent on sequence similarity to other known genes or proteins in an effort to assess the function of the gene. Combining structural and functional annotation across genomes in a comparative manner promotes higher levels of accurate annotation as well as an advanced understanding of genome evolution. As the availability of bacterial sequences increases and annotation methods improve, the value of comparative annotation will increase.
Quantitative Discomanometry (1998)

Quantitative discomanometry is a study of intradiscal pressure and volume measurements during the injection of fluid into an endplate-disc-endplate complex. The purpose of this article was to describe the technique of quantitative discomanometry, determine the reproducibility of the injection technique in a cadaveric thoracolumbar spine, and standardize the technique for future clinical investigations. Nineteen fresh human cadaveric thoracolumbar discs were injected using quantitative discomanometry to determine: (a) the time necessary for a disc to return to a baseline pressure-volume curve, (b) the reproducibility of the technique in vitro, (c) effects of the injection approach and position of the needle in the disc, and (d) effects of the type and length of tubing as well as gauge of spinal needle. A pressure-volume curve was obtained for each disc injection. Reproducibility was measured by nine parameters obtained from each pressure-volume curve: intrinsic pressure, leakage pressure, initial slope, slope between 0-0.1 ml, slope between 1-4 ml, pressure at 2 ml, pressure at 4 ml, maximum pressure, and volume at maximum pressure. The results demonstrated that (a) the injector apparatus was reproducible, (b) the time necessary for a disc to return to a baseline pressure-volume curve was 24 h, (c) the technique using fresh human cadaveric thoracolumbar discs was reproducible, (d) the anterior and posterolateral approaches had similar results if the needle was placed into the center of the nucleus pulposus using radiographic control, and (e) the type and length of tubing, and gauge of needle did not affect the results.
Men, Money, and Medicine (1970)

Ginzberg's 25 years of experience with the political economy of health seem to have led him to one major conclusion: effective reform of the medical system is rigidly bounded by economic constraints. These constraints are not only scarce manpower and money, but the realities of organization. In explaining these constraints, Ginzberg strips economic theory, industrial organization, and labor economics of their pedagogical complexities and tells it like it is in relatively simple language and easy-to-follow logic. Specifically, Ginzberg's strong points lie in three areas. He critically analyzes the common rhetoric of medical reform and implies that these fantasies only muddle-up the reform effort. Second, he shows that increasing the supply of health service personnel is necessarily an inadequate answer to the industry's problems. Third, he examines the economic nature of health industry's major participants—from the physician to the diploma nurse to the majority of workers, mainly unskilled females. Without understanding
Drug Resistance in Lung Cancer (2007)

Summary Drug resistance is an important problem in the treatment of patients with lung cancer. Tumours become resistant not only to the drugs used initially, but also to those to which they have not yet been exposed. Data obtained from various sources indicate that multiple mechanisms contribute to drug resistance. Many of them are inter-related or independent of each other, but may exist simultaneously in cancer cells or subpopulation of cells, producing an overall drug-resistant phenotype. The resistance-related proteins P-glycoprotein, glutathione-dependent enzymes, topoisomerases, metallothioneins, thymidylate synthase and O6-alkyl-DNA alkyltransferase have been found in various human lung tumours, but these alone cannot explain the drug-resistant phenotype. Cell-cycle-related proteins, angiogenic factors, protooncogenes, and tumour suppressor genes also play a role in the resistant phenotype. In future, a key challenge will be to determine the relative quantitative contributions of each of these mechanisms to overall resistance. The use of DNA microarray technology in drug resistance in lung cancer will yield insight into the mechanisms of drug resistance and the rational design of more effective strategies to circumvent resistance.