gebhart/patrepeval huggingface dataset:
New Chiral Dopants Based on the 2-Fluoro-2-Methylalkoxy Tail for Use in Ferroelectric Liquid Crystal Mixtures (1995)

Abstract A new class of FLC materials based on the 2-fluoro-2-methylalkoxy tail is reported. This new class of materials consistently shows an N* helical pitch opposite in sign to that of the polarization. These materials are compared to their 2-fluoroalkoxy analogs to explore the methyl group's effect on the N* pitch and polarization.
A nationwide study of the incidence and 30‐day mortality rate of pyogenic liver abscess in Denmark, 1977–2002 (2005)

In this large nationwide study spanning a 26-year period, we found an increasing incidence rate and a decreasing mortality rate of pyogenic liver abscess. We believe that these changes are primarily explained by more sensitive diagnostic tools.
Loudness Matching Multichannel Audio Program Material with Listeners and Predictive Models (2015)

Loudness measurements are often necessary in psychoacoustic research and legally required in broadcasting. However, existing loudness models have not been widely tested with new multichannel audio systems. A trained listening panel used the method of adjustment to balance the loudnesses of eight reproduction methods: low-quality mono, mono, stereo, 5-channel, 9-channel, 22-channel, ambisonic cuboid, and headphones. Seven programme items were used, including music, sport, and a lm soundtrack. The results were used to test loudness models including simple energy-based metrics, variants of ITU-R BS.1770, and complex psychoacoustically motivated models. The mean differences between the perceptual results and model predictions were statistically insignificant for all but the simplest model. However, some weaknesses in the model predictions were highlighted.
Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats (2012)

In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat ACE2 gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.
Combination of allyl protection and HYCRAMTM-linker technology for the synthesis of peptides with problematical amino acids and sequences (1999)

Analogues of both the nonapeptides, bradykinin and bradykinin potentiating nonapeptide BPP9α, were synthesized using HYCRAMTM-technique. The bradykinin analogues were assembled by the Boc-, Ddz- and Fmoc-strategy starting with Boc-Arg(Aloc)2-OCr–OH, Ddz-Arg(Mtr)-OCr–OH and Fmoc–Arg(Mtr)-OCr–OH. While Boc- and Ddz-strategy provide peptides in good yield and purity, the Fmoc-strategy leads to a loss of peptide from resin. For simultaneous cleavage from HYCRAMTM-resin and removal of Aloc-side chain protection optimized conditions for catalytic cleavage with Pd° were developed. As shown by the synthesis of BPP9αanalogues the HYCRAMTM-linker and the chlorotrityl resin allow the assembly of peptides with the C-terminal sequence Pro-Pro by preventing dioxopiperazine formation. Since the BPP9α sequence contains the tripeptide Trp-X-Arg an intramolecular migration of the NG-protecting group to the indole ring under conditions used for its removal had to be avoided. By the use of HYCRAMTM-linker in combination with Aloc protection for the guanidino group and Ddz for Nαno modification of Trp occurred. HYCRAMTM-technology in combination with Boc-, Ddz- or Aloc/All-protecting groups facilitates the synthesis of peptides with such very labile amino acids like cis-4-hydroxyproline.
Alloying of Al3Ti to Form Cubic Phases. (1991)

The recent discovery of cubic L12 trialuminides formed by alioying normaliy tetragonal Al3Ti with Cr, Mn and Co, whencombined with previous work with Fe, Ni, Cu and Zn as cubic stabilizing elements, makes it possible to examine changes in properties and structure as a function of the stabilizing element,
Peripheral nerve involvement in multiple sclerosis: Demonstration by magnetic resonance neurography (2017)

Peripheral nerve lesions could be visualized and quantified in MS in vivo by high-resolution MRN. Lesions are defined by an increase of proton spin density and a decrease of T2 relaxation time, indicating changes in the microstructural organization of the extracellular matrix in peripheral nerve tissue in MS. By showing involvement of the peripheral nervous system in MS, this proof-of-concept study may offer new insights into the pathophysiology and treatment of MS. Ann Neurol 2017;82:676-685.
Corneal-derived dendritic cells are critical in T cell expansion after HSV-1 ocular infection (P6102) (2013)

Abstract Corneas possess resident DC (cornea-resident DC), and infiltrating DC migrate to the draining lymph nodes (DLN) following HSV-1 corneal infection (cornea-derived DC). The relative contribution of these two DC populations and DLN-resident DC to CD4+ and CD8+ T cell expansion in DLN following HSV-1 corneal infection is unknown. Local depletion of cornea-resident DC in CD11c-DTR mice did not affect T cell expansion in the DLN. Depletion of cornea-derived DC through 3 days post infection (dpi) abrogated early (3 dpi) CD8 T cell expansion (BrdU incorporation), but only reduced CD4 T cell expansion by 50%. Systemic DC depletion through 3 dpi completely abrogated expansion of both CD4 and CD8 T cells at 3 dpi. Depletion of cornea-derived DC through 7 dpi abrogated expansion of both CD4 and CD8 T cell at 7 dpi. Cornea-derived DC showed greater expression of CD70, CD80, and CD86 relative to DLN-resident DC. Blocking CD70 co-stimulation significantly reduced CD8 T cell survival and numbers, but did not affect their proliferation. We conclude that: (i) DC are required for expansion of both HSV-specific CD4+ and CD8+ T cells; (ii) up to 3 dpi CD8 T cells absolutely require HSV-1 presentation by cornea-derived DC possibly due to their enhanced costimulation, whereas DLN-resident DC can stimulate CD4 T cells (presumably with free virus that reaches the DLN from the cornea); (iii) after 3 dpi expansion of both CD4+ and CD8+ T cells requires transport of viral antigens by cornea-derived DC.
Prognóstico tardio em jovens com coronariopatia estável: evolução em 10 anos após intervenção coronária percutânea (2012)

INTRODUÇÃO: Atualmente são ainda desconhecidas as implicações prognósticas tardias da doença arterial coronária (DAC) estável em pacientes jovens. O objetivo deste trabalho foi avaliar o prognóstico de pacientes adultos jovens com diagnóstico de DAC estável, tratados por meio de intervenção coronária percutânea (ICP) e acompanhados por até 10 anos. MÉTODOS: A população do estudo foi constituída por pacientes jovens (idade abaixo do 10o percentil) de um grupo de 1.394 pacientes consecutivos tratados para DAC estável por via percutânea. As características dos pacientes foram coletadas prospectivamente. Após o procedimento foi realizado seguimento ambulatorial, com análise do prontuário hospitalar eletrônico e contato telefônico, quando necessário. O desfecho primário foi a mortalidade geral e o desfecho secundário, a mortalidade cardiovascular. RESULTADOS: Foram selecionados 140 pacientes, com média de idade de 43,7 ± 4 anos (mínimo de 26 anos e máximo de 48 anos), predominantemente do sexo masculino (76,4%). Diabetes melito estava presente em aproximadamente um quinto dos pacientes e metade apresentava infarto prévio. Os pacientes foram seguidos por uma média de 94,6 ± 36,2 meses e a mortalidade geral no seguimento de 10 anos foi de 6%, com mortalidade cardíaca de 5,3%. Todos os pacientes que morreram obtiveram sucesso no procedimento inicial e apenas um dos casos não apresentava infarto prévio. CONCLUSÕES: Em nossa prática clínica, pacientes jovens com coronariopatia crônica tratados com ICP mostraram ter bom prognóstico tardio.
YIA5 RGS-1 Regulates Leukocyte Trafficking in Atherosclerosis and Aortic Aneurysm Formation through Chemokine Receptor Desensitisation (2014)

The regulation of macrophage recruitment and retention into the vascular wall is critical in the progression of atherosclerosis and aortic aneurysm formation. This can be mediated by chemokine activation of multiple G-protein coupled receptors. The Regulator of G-Protein Signalling-1 (RGS-1) acts to deactivate the intracellular response to sustained chemokine stimulation. We have found that RGS-1 is up-regulated with atherosclerotic plaque progression and with monocyte-macrophage activation. However little is known about the role of RGS-1 in macrophage function in vivo . Rgs-1 deficient macrophages have significantly enhanced migratory responses to atherogenic chemokines (p < 0.05) and have impaired desensitisation to repeated chemokine re-stimulation (p < 0.001). In vivo , RGS-1 has a role in the accumulation of macrophages in atherosclerotic lesions and during Angiotensin-II aortic aneurysm rupture. In the absence of RGS1, atherosclerosis is attenuated in early lesions in the aortic root and aortas of ApoE-/- mice (p < 0.001) which is accompanied by fewer macrophages in the aortic root. Rgs1-/-ApoE-/- mice are protected from Angiotensin-II induced aneurysm rupture compared to ApoE-/- mice with 94% survival vs. 56% (p = 0.0147). Rgs1-/-ApoE-/- mice have significantly fewer CD11b+ myeloid cells and CD14 + macrophages in aortas than ApoE-/- mice (p < 0.05) after 5 days of Angiotensin-II infusion. Following bone marrow transplantation, recipient mice receiving ApoE-/- bone marrow were more susceptible to aortic aneurysm rupture (p = 0.0124), indicating bone marrow-derived RGS-1 is required for aneurysm rupture. Furthermore, Angiotensin-II treatment increased systolic blood pressure to a greater extent in Rgs1-/-ApoE-/- mice than ApoE-/- mice suggesting aneurysm formation in these mice is independent of Angiotensin-II induced hypertension and this is mediated by vascular-derived RGS-1.To gain insight into the mechanism by which RGS1 regulates trafficking, we selectively labelled inflammatory monocytes in vivo to track their movement into aortas following Angiotensin-II infusion. We found an accumulation of labelled CD45 + cells in the aortas of ApoE-/- mice from day 3 to day 5 but not in Rgs1-/-ApoE-/- mice indicating RGS-1 as a regulator of macrophage retention in aortic aneurysms. These findings identify a novel role for RGS-1 in leukocyte function and vascular inflammation and identifies RGS-1 as a potential target for the treatment of cardiovascular disease.
Modification of SiO<sub>2</sub>/4H-SiC Interface Properties by High-Pressure H<sub>2</sub>O Vapor Annealing (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Intracranial nasal dermoid sinus cysts: computed tomographic scan findings and surgical results. (1994)

From July 1987 to January 1991, 14 patients, ages 1 to 19 years (mean 6 years), were seen with nasal dermoid sinus cysts, a congenital lesion with the potential for intracranial extension. Each patient was assessed clinically for cyst location, symptoms, associated craniofacial deformity, and other congenital anomalies. In 5 (36 percent) of the 14 patients, ages 4 to 48 months (mean 25 months), computed tomographic scans indicated indirect signs of intracranial extension, which were confirmed intraoperatively and histologically in all 5 patients. After neurosurgical consultation, a combined single-stage intracranial-extracranial approach was used to excise the lesion. No perioperative complications occurred. Clinical assessment (follow-up 20 to 40 months, mean 31 months), confirmed by postoperative CT scan 1 year after surgery, indicated no evidence of recurrence, residual skeletal contour defects, or deformity; forehead and nasal growth were qualitatively normal, and scar appearance was satisfactory. Our experience indicates that intracranial extension of nasal dermoid sinus cysts seen at a tertiary care referral center are not rare, that computed tomography scan permits accurate diagnosis, and that the single-stage intracranial-extracranial approach to resection is effective and results in minimal morbidity.
From molecules to materials: some examples in yttrium and lanthanide chemistry (2004)

Hydrolytic and hydrothermal transformations were applied to yttrium alkoxides, namely Y 5 O(O i Pr) 13 , Y 3 (O t Bu) 9 ( t BuOH) 2 and [Y 8 O 6 (O t Bu) 12 ] m . The resulting powders were characterized by XRD, TGA and transmission electron microscopy (TEM). Hydrolysis of the octanuclear oxo species gave nanocrystalline (5–6 nm) cubic Y 2 O 3 at 400 °C by annealing of an oxohydroxide. Hydrothermal transformation in basic media (200 °C, 10 h, 17 atm) of Y 5 O(O i Pr) 13 gave amorphous Y 2 O 3 as well as crystalline platelets and nanowires of Y(OH) 3 . Transformation into cubic yttria was achieved at 300 °C. The lability of the M–OR bond allows easy formation of mixed-metal species, giving access to doped materials of high homogeneity and crystallinity, as shown by a Y 2 O 3 matrix doped by Pr 2 O 3. Modification of Y 5 O(O i Pr) 13 by polymerisable ligands provided molecular oxohydroxide aggregates that can be used for access to organic-inorganic materials by copolymerisation reactions.
Severe hemolysis and red cell fragmentation caused by the combination of a spectrin mutation with a thrombotic microangiopathy (1989)

Two patients are described who presented with severe hemolysis and erythrocyte fragmentation. One patient had renal allograft rejection and disseminated intravascular coagulation, and the other had thrombotic thrombocytopenia purpura. The severity of hemolysis and the red cell abnormalities were considerably more profound than usually seen in patients with thrombotic microangiopathies. After evaluation of blood smears prepared before the onset of the disease and biochemical characterization of proteins of the red blood cell skeleton, a mutation of the skeletal protein spectrin, designated Sp alpha l/65, was identified. In the heterozygous form, this mutation manifests as mild, often asymptomatic, hereditary elliptocytosis. We conclude that in these two patients with thrombotic microangiopathy, the intrinsic red cell membrane instability resulting from the underlying skeletal defect aggravated the mechanical red cell fragmentation, producing morphological features similar to the severe hemolytic form of hereditary elliptocytosis or hereditary pyropoikilocytosis.
Effect of active species mobility on soot‐combustion over Cs‐V catalysts (2003)

Abstract The soot combustion process promoted by some of the most promising diesel particulate combustion catalysts (Cs 2 O·V 2 O 5 , Cs 4 V 2 O 7 , CsVO 3 ) is discussed on the grounds of a theoretical analysis and an experimental test campaign involving reaction runs in microreactors (either in isothermal or in temperature‐programmed conditions) and in a DSC apparatus. Such investigations, beyond the prevalent kinetic parameters (activation energy, oxygen reaction order, preexponential kinetic constant), led to a definition of the role of catalyst‐to‐carbon contact conditions on the conversion rate. Particularly, the role of formation of eutectic liquid phases, which dominates the catalytic behavior of the Cs 2 O·V 2 O 5 catalyst, was fully elucidated on the grounds of either DSC runs or visual inspection through a heated optical microscope.
Comparison of Commercial and Self-Initiated Weight Loss Programs in People With Prediabetes: A Randomized Control Trial (2016)

To determine if a widely available weight-management program (Weight Watchers) could achieve sufficient weight loss in persons with prediabetes compared with a Diabetes Prevention Program-based individual counseling program supported by National Diabetes Education Program materials.\nMETHODS:\n\nWe conducted an individual, randomized intervention trial in Indianapolis, Indiana, in 2013 to 2014, in 225 persons with prediabetes. We compared the Weight Watchers weight-management program (n = 112) with Your Game Plan to Prevent Type 2 Diabetes, a program developed by the National Diabetes Education Program. Outcomes were weight and metabolic markers measured at baseline, 6 months, and 12 months.\nRESULTS:\n\nIntervention participants lost significantly more weight than controls at 6 months (5.5% vs 0.8%) and 12 months (5.5% vs 0.2%; both P < .001). The intervention group also had significantly greater improvements in hemoglobin A1c and high-density lipoprotein cholesterol level than did controls.\nCONCLUSIONS:\n\nA large weight-management program is effective for achieving lifestyle changes associated with diabetes prevention. Such programs could significantly increase the availability of diabetes prevention programs worldwide making an immediate and significant public health impact.
[Remarkable effect of gemcitabine-oxaliplatin (GEMOX) therapy in a patient with advanced metastatic mucinous cystic neoplasm of the pancreas]. (2008)

Gemcitabine(GEM)is the standard therapy for advanced pancreatic cancer. GEM-oxaliplatin (GEMOX) combination treatment has been reported to be superior to GEM alone in terms of clinical progression-free survival, but it is not the therapy of choice for pancreatic cancer. We report a case of advanced mucinous cystic neoplasm (MCN) of the pancreas with multiple hepatic metastases in a 39-year-old female. She was treated with 16 courses of GEMOX (GEM 1,500 mg/day at a rate of 10 mg/m2/min on the first day and oxaliplatin 150 mg/day at 100 mg/m2 on the second day, every 3 weeks). The pharmacist helped her to avoid severe side effects. When the hepatic metastases disappeared after 13 courses, the primary MCN was removed surgically after 16 courses of GEMOX treatment. No recurrence has been observed 22 months postoperatively. GEMOX might be effective for the treatment of MCN of the pancreas.
Combination of finite element simulations and linear systems theory for pulse shaping of piezoelectric transducers used in therapy (2003)

A simulation procedure is presented to calculate the focal ultrasound pressure pulse from the driving voltage of a piezoelectric composite transducer or to calculate the required voltage from a given focal pressure pulse. The description of the transducer system including the driving circuit is done by linear systems theory. A transducer transfer function is derived by transient finite element simulations of the transducer structure. Focusing is assumed to be linear, which is valid for small amplitudes. Measurements validate the model.
Performance evaluation of a lead-titanate (PbTiO<sub>3</sub>) pyroelectric thin-film infrared sensor with temperature isolation improvement structure by microelectromechanical system (MEMS) technologies (1998)

An IR sensor with the lead-titanate thin-film using the technology of micro-electro-mechanical systems to achieve a better thermal isolation structure has been fabricated and developed. The major IR-sensing part on the cantilever beam with dimensions of 200 X 100 X 2 micrometers <SUP>3</SUP> consists of a 500-angstrom lead-titanate layer deposited by RF sputtering, and an evaporated bismuth layer. This thermal isolation improved structure exhibits a much superior performance to that of a traditional IR-sensing bulk structure on the experimental results, which show a 200 percent and 300 percent improvement in current gain under the incident optical power 500 (mu) W and 6V applied bias at room temperature and 77 degrees K, respectively.
Development of two‐axis electromagnetic driving MEMS mirror (2011)

Abstract We propose a new two‐axis electromagnetic scanning mirror that utilizes radial magnetic fields. By positioning magnets under the mirror, we were able to develop a greatly miniaturized mirror device. This device's volume is 300 mm 3 . Moreover, the mirror driving magnetic induction can be enlarged by forming a closed magnetic field with the yoke and the magnets. To assemble it easily, the upper part of all magnets was assumed to be the N pole. To optimize the composition of the yoke and the magnets, the magnetic induction of the space was calculated by magnetic simulation. We made the mirror by the bulk micromachining process, and performed a drive experiment. The mirror scanning angle was 10° at 100 mA P‐P for a resonant frequency of 6 kHz, and the frame scanning angle was 1 degree at 100 mA P‐P for a nonresonant frequency of 60 Hz. The calculation and measurement results were almost the same. © 2011 Wiley Periodicals, Inc. Electron Comm Jpn, 94(11): 18–23, 2011; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/ecj.10378
Differential expression of menin in various adrenal tumors (2001)

The findings of the current study indicate that menin expression appears to be up-regulated in Cushing syndrome, suggesting that adrenocortical proliferation might be one of the primary lesions in the MEN1 syndrome in which menin might play a significant role in some specific cellular functions.
Synthesis of a Capillarisin Sulfur‐Analogue Possessing Aldose Reductase Inhibitory Activity by Selective Isopropylation. (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Limit of intraoperative near-infrared spectroscopy monitoring during endovascular thrombectomy in acute ischemic stroke (2017)

Endovascular thrombectomy is recommended for a persistent ischemic penumbra if recanalization cannot be achieved by the intravenous (IV) administration of recombinant tissue-plasminogen activator (rt-PA) alone. Although endovascular thrombectomy is a powerful treatment for major cerebral artery occlusion, the monitoring of recanalization and reperfusion during acute ischemic stroke presents a therapeutic challenge, and a previous study reported the usefulness of near-infrared spectroscopy (NIRS) for intraoperative monitoring during emergency endovascular thrombectomy for acute large ischemic stroke. Here we present our experience with a relevant case series. We applied NIRS monitoring during endovascular thrombectomy in two patients with large ischemic stroke following carotid artery occlusion and one patient with a non-large ischemic stroke caused by a distal middle cerebral artery (MCA) occlusion. In the patients with large ischemic stroke, complete recanalization of the internal carotid artery was achieved, and NIRS revealed a very good regional oxygen saturation (rSO<sub>2</sub>) response. By contrast, in the patient with non-large ischemic stroke, the rSO<sub>2</sub> did not change, despite complete recanalization of the distal MCA. Our findings suggest the limited usefulness of intraoperative NIRS monitoring during emergency endovascular thrombectomy for non-large acute ischemic stroke caused by a distal MCA occlusion. However, intraoperative NIRS monitoring could be used practically to detect recanalization of the major artery during thrombectomy and early IV rt-PA administration in cases involving major artery occlusion.
Synthesis and Characterization of Highly Fluorescent and Thermally Stable π-Conjugates involving Spiro[fluorene-9,4'-[4H]indeno[1,2-b]furan] (2010)

Spiro[fluorene-9,4'-[4H]indeno[1,2-b]furan] was synthesized, and its <TEX>$\pi$</TEX>-conjugation was efficiently elongated using palladium-catalyzed C-H arylation of a furan moiety. The resulting <TEX>$\pi$</TEX>-conjugated compounds showed intense fluorescence and extremely high thermal stability.
Characterization of Electrodeposited Copper Films with Time-of-Flight SIMS (2009)

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009