gebhart/patrepeval huggingface dataset:
The exceptional responsiveness of certain human myeloid leukemia cells to colony-stimulating activity (1979)

We have studied the marrow cells from a patient with acute myeloid leukemia (AML) for their responsiveness to colony-stimulating activity (CSA) in vitro. The AML cells were stimulated by CSA to rapid and extended growth in liquid culture. In the absence of CSA, the majority of cells died. CSA also stimulated the clonal growth of AML cells, and the minimum requirement for CSA was one-tenth to one-fiftieth that required to stimulate the growth of normal marrow CFU-C. CSA for AML cells was eluted from Sephacryl S-200 columns in fractions that represented an apparent molecular weight of 45,000 daltons. This fraction also produced optimal stimulation of normal human marrow. During remission, the patient's marrow cells did not grow in liquid culture and produced normal numbers of granulocytic and erythroid colonies in response to CSA and erythropoietin. Extended culture of the AML cells resulted in cell differentiation evidenced by decreasing proliferative capacity and by morphological and histochemical changes. These studies indicate that certain AML cells are extraordinarily responsive to CSA, an in vitro mediator of normal granulopoiesis.
Nanoscale Structure of the Oil-Water Interface (2016)

X-ray reflectivity (XR) and atomistic molecular dynamics (MD) simulations, carried out to determine the structure of the oil-water interface, provide new insight into the simplest liquid-liquid interface. For several oils (hexane, dodecane, and hexadecane) the XR shows very good agreement with a monotonic interface-normal electron density profile (EDP) broadened only by capillary waves. Similar agreement is also found for an EDP including a sub-Å thick electron depletion layer separating the oil and the water. The XR and MD derived depletions are much smaller than reported for the interface between solid-supported hydrophobic monolayers and water.
wave-current interaction with macro-roughness environment (2020)

Data for solitary wave interactions with array of structures
Mechanisms of Surface Charge Modification of Carbonates in Aqueous Electrolyte Solutions (2019)

The influence of different types of salts (NaCl, CaCl 2 , MgCl 2 , NaHCO 3 , and Na 2 SO 4 ) on the surface characteristics of unconditioned calcite and dolomite particles, and conditioned with stearic acid, was investigated. This study used zeta potential measurements to gain fundamental understanding of physico-chemical mechanisms involved in surface charge modification of carbonate minerals in the presence of diluted salt solutions. By increasing the salt concentration of divalent cationic salt solution (CaCl 2 and MgCl 2 ), the zeta potential of calcite particles was altered, resulting in charge reversal from negative to positive, while dolomite particles maintained positive zeta potential. This is due to the adsorption of potential-determining cations (Ca 2 + and Mg 2 + ), and consequent changes in the structure of the diffuse layer, predominantly driven by coulombic interactions. On the other hand, chemical adsorption of potential-determining anions (HCO 3 − and SO 4 2 − ) maintained the negative zeta potential of carbonate surfaces and increased its magnitude up to 10 mM, before decreasing at higher salt concentrations. Physisorption of stearic acid molecules on the calcite and dolomite surfaces changed the zeta potential to more negative values in all solutions. It is argued that divalent cations (Ca 2 + and Mg 2 + ) would result in positive and neutral complexes with stearic acid molecules, which may result in strongly bound stearic acid films, whereas ions resulting in negative mineral surface charges (SO 4 2 − and HCO 3 − ) will cause stearic acid films to be loosely bound to the carbonate mineral surfaces. The suggested mechanism for surface charge modification of carbonates, in the presence of different ions, is changes in both distribution of ions in the diffuse layer and its structure as a result of ion adsorption to the crystal lattice by having a positive contribution to the disjoining pressures when changing electrolyte concentration. This work extends the current knowledge base for dynamic water injection design by determining the effect of salt concentration on surface electrostatics.
Superman: Man of Steel!...Or...Man of Boycott? (2014)

In February 2013, DC announced a special anthology of Superman stories that would be co-written by Orson Scott Card, who had actively spoken out against gay marriage. In response to the announced hiring of Card, over 16,000 people signed a petition to boycott the anthology (Truitt, 2013). Further, a few comic book retailers had refused to carry DC’s iconic Superman comics (Sieczkowski, 2013). The Superman franchise was one of DC Comics most profitable assets. At stake were not only graphic novel sales, but also movies and memorabilia. The concerns over how the boycott could affect movie revenues were particularly troubling since DC would be introducing a new Superman movie into theaters in June 2013. DC was counting on this movie being one of the summer blockbuster hits. Executives at DC Comics needed to determine the best course of action in light of the negative publicity surrounding Orson Scott Card’s position as a writer on the anthology.
[Applicability to abrasion material of in vitro autoradiography, using 3H-thymidine (author's transl)]. (1980)

The applicability of in vitro autoradiography, using 3H-thymidine, was tested on material obtained from gynaecological abrasion. Included were 161 abrasion samples obtained from 151 patients, and 88 per cent of them proved evaluable by autoradiography. The use of in vitro autoradiography was found to give no additional gain in information for biological assessment. Index testing by means of in vitro autoradiography failed to prove worthwhile unless it came to examination of polyps or of glandular-cystic hyperplasia or of effects exerted on the endometrium by ovarian tumours with sizeable hormonal activity. Endometrium was found to be a kind of tissue characterised in both intact and pathological condition by pronounced individual age-dependent and cycledependent variations of its marking indices.
Reticulin Expression Demonstrates Hormonal Responsiveness in a Model of Cycling Human Endometrium (2001)

Papers on Current Clinical and Basic Investigation: Poster Sessions Monday, April 30, 2001: Menopause: PDF Only
The intracellular domain of Notch ligand Delta1 induces cell growth arrest (2005)

Notch signaling involves proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands, Delta or Jagged; and the resultant soluble intracellular domain of Notch stimulates a cascade of transcriptional events. The Delta1 ligand also undergoes proteolytic cleavage upon Notch binding, resulting in the production of a free intracellular domain. We demonstrate that the expression of the intracellular domain of Delta1 results in a non-proliferating senescent-like cell phenotype which is dependent on the expression of the cell cycle inhibitor, p21, and is abolished by co-expression of constitutively active Notch1. These data suggest a new intracellular role for Delta1.
One Pot Direct Synthesis of Oxazolines, Benzoxazoles, and Oxadiazoles from Carboxylic Acids Using the Deoxo‐Fluor Reagent. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An algorithm of global routing for gate array LSI (1984)

Abstract With the progress of microelectronics technology, the amount of design for a variety of LSI's is increasing rapidly. to make the design and production of such LSI's easier and less costly, a gate array LSI is used extensively. This paper describes a global router for gate array LSI's which is incorporated into our layout system. This router is used to generate for each net an interconnection pattern consisting of channel segments in such a unified way that all interrelated interconnection requirements are taken into account at once. A main objective of the router is not only to minimize the maximum of the local wiring densities, but also to distribute all the interconnection requirements over channels evenly to attain 100% interconnection within a limited area.
Evidence-based management of irritable bowel syndrome with diarrhea. (2018)

Irritable bowel syndrome (IBS), a complex disorder of the gastrointestinal tract, is characterized by abdominal pain associated with defecation or changes in stool form or frequency. IBS is associated with substantial burden, including direct medical costs and indirect costs. Direct costs associated with IBS in the United States have been estimated to exceed $1 billion. However, indirect costs, such as negative effect on quality of life (QOL) and work productivity, are difficult to quantify. There are 3 main subtypes: IBS with prominent diarrhea (IBS-D), IBS with constipation, and IBS with mixed symptoms of both constipation and diarrhea. A number of pharmacologic agents have been used to treat IBS-D despite lack of approval by the FDA for this indication. The pharmacologic agents that are indicated by the FDA for the treatment of IBS-D include alosetron, eluxadoline, and rifaximin. The negative impact of IBS-D symptoms on QOL reported by patients indicate there is an unmet need for therapies that effectively treat and manage the symptoms of this condition. Addressing gaps in treatment is an important priority.
<i>Ansa</i>‐Complexes of [Mn(η<sup>5</sup>‐C<sub>5</sub>H<sub>5</sub>)(η<sup>6</sup>‐C<sub>6</sub>H<sub>6</sub>)]: Preparation, Characterization, and Reactivity of [<i>n</i>]Manganoarenophanes (<i>n</i>=1, 2, 3) (2015)

We report the synthesis of [n]manganoarenophanes (n=1, 2) featuring boron, silicon, germanium, and tin as ansa-bridging elements. Their preparation was achieved by salt-elimination reactions of the dilithiated precursor [Mn(η(5) -C5 H4 Li)(η(6) -C6 H5 Li)]⋅pmdta (pmdta=N,N,N',N',N''-pentamethyldiethylenetriamine) with corresponding element dichlorides. Besides characterization by multinuclear NMR spectroscopy and elemental analysis, the identity of two single-atom-bridged derivatives, [Mn(η(5) -C5 H4 )(η(6) -C6 H5 )SntBu2 ] and [Mn(η(5) -C5 H4 )(η(6) -C6 H5 )SiPh2 ], could also be determined by X-ray structural analysis. We investigated for the first time the reactivity of these ansa-cyclopentadienyl-benzene manganese compounds. The reaction of the distannyl-bridged complex [Mn(η(5) -C5 H4 )(η(6) -C6 H5 )Sn2 tBu4 ] with elemental sulfur was shown to proceed through the expected oxidative addition of the Sn-Sn bond to give a triatomic ansa-bridge. The investigation of the ring-opening polymerization (ROP) capability of [Mn(η(5) -C5 H4 )(η(6) -C6 H5 )SntBu2 ] with [Pt(PEt3 )3 ] showed that an unexpected, unselective insertion into the Cipso -Sn bonds of [Mn(η(5) -C5 H4 )(η(6) -C6 H5 )SntBu2 ] had occurred.
H-2 antigens as markers of cellular genotype in chimaeric mice. (1983)

We describe an immunohistochemical method, using monoclonal anti-H-2 antibodies, for demonstrating H-2 antigens in cryostat sections of a variety of mouse tissues. Double staining allows simultaneous demonstration of both cell populations in tissue sections from H-2b in equilibrium H-2k aggregation chimaeras.
3D nanofabrication by reverse contact UV nanoimprint lithography (2007)

We have developed and demonstrated a new fabrication technique to realise multilayered polymer structures with sub-micrometer features. Using the same UV curable polymer, it was possible to pattern over topography building up several layers without having to etch the polymer residual layer at intermediate stages. The elimination of the oxygen RIE step enhances the throughput of nanoimprint lithography and the transfer pattern fidelity. This technique is reproducible over millimetres scale surface areas and gives encouraging results for the fabrication of integrated polymer photonic devices.
Computing the Newtonian Graph (Extended abstract) (1993)

A polynomial $f\in \complex[z]$ defines a vector field $N_f(z) = -f(z)/f'(z)$ on $\complex$. Certain degenerate curves of flow in $N_f$ give the edges of the Newtonian graph, as defined by \cite{Sma85}. These give a relation between the roots of $f$ and $f'$, much similar to the linear order, when $f$ has real roots only. We give a purely algebraic algorithm to compute the Newtonian graph and the basins of attraction in the Newtonian field. The resulting structure can be used to query whether two points in $\complex$ are within the same basin of attraction. This gives us an algebraic approach to root-finding using Newton's method. This method extends to rational functions and more generally to any functions on $\complex$ whose flow is algebraic over $\complex(e)$.
ChemInform Abstract: Synthesis and Biological Activity of Largazole (Ia) and Derivatives. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Improved technology for spun-cast concrete poles (1984)

Different types of concrete were investigated with the goal of developing concrete suitable for the production of spun-cast concrete poles. A total of 65 different concrete mixes were investigated, with the suitability criteria defined as: compactability, no segregation of the mix components during the spinning operation, no shrinkage cracking, high strength, and durability. High strength normal weight concretes and semi-lightweight concretes, both with and without fly ash and/or silica fume and with different types of admixtures were used to produce spun-cast concrete pole segments. Of the 35 lightweight concretes only 3 were considered successful, as in all other specimens the inner layer of coarse aggregate was not well embedded in the mortar, and many mixes could not be compacted properly because they were too stiff, too wet, or started to set before spinning commenced. The three successful specimens contained fly ash and one contained silica fume, and had low water/cement ratios (0.26 to 0.29). Of the 23 normal weight concretes tested, only 5 were considered suitable, and all these had a sand/coarse aggregate ratio of 0.25 or smaller and a cement content between 350 and 400 kg/m{sup 3}. A theoretical study of the stresses in the end zones of pretensioned poles is presented. 10 refs., 53 figs., 14 tabs.
Effects of extracellular matrix on cytoskeletal and myofibrillar organization in vitro. (1989)

The distribution and three-dimensional relationship of myofibrillar and cytoskeletal components during myofibrillogenesis were examined in preparations of neonatal rat cardiac myocytes processed in parallel for scanning electron microscopy (SEM), intermediate voltage transmission electron microscopy (IVEM) and immunofluorescence (IF). Of the various methods used for processing, optimal results were achieved by pre-extraction with Triton X-100 in an actin-stabilizing buffer. This procedure effectively removed the surface membrane, as viewed by SEM images, while preserving myofibrillar and cytoskeletal structure, as evidenced by IF for actin, alpha-actinin and vinculin. Cytoskeletons in SEM images consisted of a cortex of anastomosing filaments through which ran parallel filament bundles oriented in the long axis of the cell and attached along their length to the substrate by numerous fine filaments. In IVEM images, myofibrils were laterally connected at the level of the Z bands. Myocytes grown on different extracellular matrices showed different patterns and distributions of both striated myofibrils and focal adhesions, as determined by IF for alpha-actinin and vinculin, respectively. Cells on collagen I and III contained striated myofibrils which extended to the cell perimeters where focal adhesions were predominately located. Cells on laminin and fibronectin matrices exhibited myofibrils and focal adhesions more centrally located. In addition, cells on laminin contained circumferential arcs of filaments near the cell periphery.
The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks (2016)

We recently reported that the serotonin transporter polymorphism 5-HTTLPR moderates the relation between stress exposure and attention-deficit/hyperactivity disorder (ADHD) severity. This gene-environment interaction (GxE) has been previously tied to the processing of emotional stimuli, which is increasingly recognized to be a key factor in ADHD-related impairment. The executive control and default mode brain networks play an important role in the regulation of emotion processing, and altered connectivity of these networks has also been associated with ADHD. We therefore investigated whether resting-state connectivity of either of these networks mediates the relation of 5-HTTLPR and stress exposure with ADHD severity. Resting-state functional magnetic resonance imaging, genetic, and stress exposure questionnaire data was available for 425 adolescents and young adults (average age 17.2 years). We found that 5-HTTLPR S-allele carriers showed a more negative relation between stress exposure and connectivity of the executive control network than L-allele homozygotes, specifically in the pre/postcentral gyrus, striatum, and frontal pole. In the default mode network, we found a positive association between the GxE and supramarginal gyrus connectivity. Connectivity of either network did not significantly mediate the effect of this GxE on ADHD. Opposite effects of stress exposure on connectivity in the executive and default mode networks may contribute to findings that stress exposure is associated with lowered cognitive control and heightened levels of rumination and worrying, for S-allele carriers but not L-allele homozygotes. When combined, these effects on connectivity of both networks may relate to the emotional problems seen in individuals with ADHD.
Locating faces using statistical feature detectors (2002)

We describe a method of locating hypotheses for the positions of faces in an image. We use statistical feature detectors to locate candidates for features, then use a statistical model of the shape and orientation of the features to test combinations of such features to find the most plausible. The best sets can be used as the initial position of an Active Shape Model, which can then accurately locate the full face.
DP-based wordgraph pruning (2002)

We present an efficient technique of generating word graphs in a continuous speech recognition system. The word graph is constructed in two stages. In the first stage, a huge word graph is generated as a by-product of a beam-driven forward search. Based on a dynamic-programming (DP) method, this huge word graph will be pruned in the second stage using higher level knowledge, such as n-gram language models. In this pruning stage an edge is removed if there is no path going through this edge which is better scored as the best-scored path in the word graph. The proposed technique is evaluated in the German VERBMOBIL task.
Discriminatory Power of RAPD,PCR-RFLP and Southern Blot Analyses of ureCD or ureA Gene Probes on Helicobacter pylori Isolates (2002)

The genetic diversity of 33 Nigerian Helicobacter pylori isolates were studied using RAPD, PCR-RFLP and Southern blot analysis of ureA or ureCD gene probes. RAPD was able to distinguish the following number of isolates using the primers 3880: 5'-AAGAGCCCGT-3' (28), 3881 :5'-AACGCGCAAC-3' (33) and OPH8 :5'-GAAACACCCC-3' (25). Southern blot analysis using the ureCD probe was also able to distinguish the 12 isolates tested into ten different patterns. The PCR-RFLP technique distinguished all 33 isolates into six types. In conclusion, considering typeability, discriminatory power, and convenience, RAPD with the 3881 primer was considered the most useful technique.
SSR analysis with a new analytical model of Thyristor Controlled Series capacitor (2005)

This paper presents the use of new model of a Thyristor Controlled Series Capacitor (TCSC) in studies of subsynchronous resonance (SSR). The new analytical model is developed by using frequency re- sponse of the non-linear TCSC segment to derive a simplified non-linear state space model, where the fre- quency of the dominant TCSC complex poles shows linear dependence on the firing angle. The non-linear TCSC model is linearised and linked with the generator- shaft system model and the controller model that also includes a Phase Locked Loop model. The test system selected for the study is the IEEE first benchmark model for SSR studies. The SSR analysis is studied through eigenvalues analysis using MATLAB and the results are validated through PSCAD/EMTDC simulation studies.
Reactive intermediates. Part XXVI. Flash vacuum pyrolysis of phenyl-substituted 1,2,4-triazoles; a new synthesis of isoindoles (1975)

The nine mono-, di-, and tri-phenyl-1,2,4-triazoles have been subjected to flash vacuum pyrolysis at 650–800°, and the products have been isolated and identified. 1,3,5- and 3,4,5-Triphenyl-1,2,4-triazole both gave 1,3-diphenylisoindole in good yield. The formation of this product requires the extrusion of nitrogen from the triazoles, for which a mechanism is suggested involving a [1,5] phenyl shift and the generation of a non-aromatic 3H-1,2,4-triazole intermediate. The four diphenyl-1,2,4-triazoles reacted similarly to give 1-phenylisoindole, which was oxidised during work-up to 3,3′-diphenylbi-1H-isoindol-1-ylidene, and 1-phenyl-1,2,4-triazole gave isoindole, which was isolated as its Diels–Alder adduct with N-phenylmaleimide.3-Phenyl-1,2,4-triazole underwent fragmentation in a different way, giving benzonitrile and cyanamide. From 4-phenyl-1,2,4-triazole a highly unstable product, thought to be N-cyano-N-phenylformamidine, was isolated at low temperatures. This product reacted with N-phenylmaleimide to give 2-(N-cyanoanilino)-N-phenyl-succinimide (7) for which a mechanism involving the transient formation of monophenylcarbodi-imide is suggested. An independent synthesis of the cyanamide (7) depended upon the formation of the lithium salt of phenylcyanamide from 1-phenyltetrazole and butyl-lithium.4-(2,4,6-Trimethylphenyl)-1,2,4-triazole gave (2-amino-4,6-dimethylphenyl)acetonitrile (11) on pyrolysis, probably through 2-amino-5,7-dimethyl-3H-indole (10) as intermediate. This amino-indole readily isomerised on pyrolysis to give the phenylacetonitrile (11).
The <i>Drosophila</i> centrosomal protein Nuf is required for recruiting Dah, a membrane associated protein, to furrows in the early embryo (1999)

During mitosis of the Drosophila cortical syncytial divisions, actin-based membrane furrows separate adjacent spindles. Our genetic analysis indicates that the centrosomal protein Nuf is specifically required for recruitment of components to the furrows and the membrane-associated protein Dah is primarily required for the inward invagination of the furrow membrane. Recruitment of actin, anillin and peanut to the furrows occurs normally in dah-derived embryos. However, subsequent invagination of the furrows fails in dah-derived embryos and the septins become dispersed throughout the cytoplasm. This indicates that stable septin localization requires Dah-mediated furrow invagination. Close examination of actin and Dah localization in wild-type embryos reveals that they associate in adjacent particles during interphase and co-localize in the invaginating furrows during prophase and metaphase. We show that the Nuf centrosomal protein is required for recruiting the membrane-associated protein Dah to the furrows. In nuf-mutant embryos, much of the Dah does not reach the furrows and remains in a punctate distribution. This suggests that Dah is recruited to the furrows in vesicles and that the recruiting step is disrupted in nuf mutants. These studies lead to a model in which the centrosomes play an important role in the transport of membrane-associated proteins and other components to the developing furrows.