gebhart/patrepeval huggingface dataset:
Efficient CO<sub>2</sub> Capture by Porous, Nitrogen‐Doped Carbonaceous Adsorbents Derived from Task‐Specific Ionic Liquids (2012)

The search for a better carbon dioxide (CO(2) ) capture material is attracting significant attention because of an increase in anthropogenic emissions. Porous materials are considered to be among the most promising candidates. A series of porous, nitrogen-doped carbons for CO(2) capture have been developed by using high-yield carbonization reactions from task-specific ionic liquid (TSIL) precursors. Owing to strong interactions between the CO(2) molecules and nitrogen-containing basic sites within the carbon framework, the porous nitrogen-doped compound derived from the carbonization of a TSIL at 500 °C, CN500, exhibits an exceptional CO(2) absorption capacity of 193 mg of CO(2) per g sorbent (4.39 mmol g(-1) at 0 °C and 1 bar), which demonstrates a significantly higher capacity than previously reported adsorbents. The application of TSILs as precursors for porous materials provides a new avenue for the development of improved materials for carbon capture.
Aircraft Alerting Systems Criteria Study. Volume 1. Collation and Analysis of Aircraft Alerting Systems Data (1977)

Several recent studies, performed to develop optimum alerting methods for new alerts that had to be retrofitted to existing aircraft, identified as major alerting system problems the proliferation of alerting systems and the inconsistent application of alerting concepts in current commercial transport aircraft. The objective of this study was to address these problem areas in the following manner: refine and augment the stimuli response data collected under the previous studies, provide test plans for additional stimuli response tests required to complete the stimuli response data base, provide tabulations of the alerting methods and alerting requirements used on current commercial transport aircraft, develop a method for prioritizing alerting functions and prioritizing the alerting functions accordingly, note conflicts between current alerting requirements and the prioritized lists of alerts, and provide recommendations for standardization of alerting functions/methods. The output includes a collation of human factors data pertinent to alerting systems, cursory test plans for obtaining missing human factors data required to complete definition of and validate the standards recommended for alerting systems, criteria for alert priority levels, an example tabulation of alerts that might fall within each priority level, and recommended methods of annunciating the alerts within each priority level.
RELEASE OF PROPYL PARABEN FROM A POLYMER COATING INTO WATER AND FOOD SIMULATING SOLVENTS FOR ANTIMICROBIAL PACKAGING APPLICATIONS (2001)

The release phenomena of propyl paraben from a polymer coating to water and three food simulating solvents (10% aqueous ethanol, 50% aqueous ethanol, n-heptane) were studied for antimicrobial packaging applications. The effects of food simulating solvent, initial concentration in the coating and temperature on the propyl paraben release were examined. The initial concentration of propyl paraben in the coating ranged from 1.26 × 104 to 10.52 × 104 g/m3 and the temperature from 5.5 to 30C. For water, the release was controlled by Fickian diffusion with constant diffusion coefficient (7±11 × 10-11 cm2/s at 30C), and independent of the initial concentration. For 10% ethanol, the release followed again the Fickian model with constant diffusion coefficient (30±40 × 10-11 cm2/s at 30C). For 50% ethanol and n-heptane, the release was instantaneous and not controlled by Fickian diffusion. For the release into water, the activation energy for diffusion from the Arrhenius relationship was around 88 kJ/mole.
Störungsunterdrückung durch Zustandsregelung / Disturbance rejection by state feedback control (1980)

Article Störungsunterdrückung durch Zustandsregelung / Disturbance rejection by state feedback control was published on December 1, 1980 in the journal at - Automatisierungstechnik (volume 28, issue 1-12).
Hydroformylation Catalyzed by Rhodium/Fluorinated Triarylphosphite Complexes in Fluorous Biphasic Media (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Opposing Roles of Dectin-1 Expressed on Human Plasmacytoid Dendritic Cells and Myeloid Dendritic Cells in Th2 Polarization (2015)

Dendritic cells (DCs) can induce and control host immune responses. DC subset-dependent functional specialties and their ability to display functional plasticity, which is mainly driven by signals via pattern recognition receptors, identify DCs as immune orchestrators. A pattern recognition receptor, Dectin-1, is expressed on myeloid DCs and known to play important roles in Th17 induction and activation during fungal and certain bacterial infections. In this study, we first demonstrate that human plasmacytoid DCs express Dectin-1 in both mRNA and protein levels. More interestingly, Dectin-1-activated plasmacytoid DCs promote Th2-type T cell responses, whereas Dectin-1-activated myeloid DCs decrease Th2-type T cell responses. Such contrasting outcomes of Th2-type T cell responses by the two DC subsets are mainly due to their distinct abilities to control surface OX40L expression in response to β-glucan. This study provides new insights for the regulation of host immune responses by Dectin-1 expressed on DCs.
Microreaction Technology as a Novel Approach to Drug Design, Process Development and Reliability (2001)

This paper focuses on the application of microreaction technology in the life science industry. Certain features of microreaction technology, for example, mixing, heat transfer, and residence time distribution, are discussed. Important advantages such as high operational safety and the possibility to transfer the experimental results directly from laboratory to the production of pilot-plant scales are mentioned. Potential application fields in the drug discovery and development processes, from research to production, by including chemical synthesis of different targets in the case of the quinoline acid derivative (ciprofloxacin) and the Paal−Knorr pyrrole synthesis are presented.
In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway (2002)

The interleukin 6/glycoprotein 130/signal transducer and activator of transcription 3 (IL-6/gp130/STAT3) pathway has been reported to play an important role in the pathogenesis of multiple myeloma (MM) and for survival of MM cells. However, most data concerning the role of IL-6 and IL-6-triggered signaling pathways were obtained from experiments performed with MM cell lines and without considering the bone marrow microenvironment. Thus, the precise role of IL-6 and its intracellular signaling pathways for survival of human MM cells is still unclear. Here we show that treatment of human MM cells (IL-6-dependent MM cell line INA-6 and primary MM cells) with the IL-6 receptor antagonist Sant7 or with an anti-gp130 monoclonal antibody (mAb) induced apoptosis if the cells were cultured in the absence of bone marrow stromal cells (BMSCs). In contrast, apoptosis could not be observed if the MM cells were cocultured with BMSCs. The analysis of intracellular pathways revealed that Sant7 and anti-gp130 mAb were effectively inhibiting the phosphorylation of gp130 and STAT3 in the absence and presence of BMSCs, whereas ERK1 and ERK2 (ERK1,2) phosphorylation was only slightly affected. In contrast, treatment with the farnesyl transferase inhibitor, FPT III, induced apoptosis in MM cells in the absence or presence of BMSCs and led to a complete inhibition of the Ras/mitogen-activated protein kinase pathway. These observations indicate that the IL-6/gp130/STAT3 pathway is not essential for survival of human myeloma cells if they are grown in the presence of cells from the bone marrow microenvironment. Furthermore, we provide evidence that farnesyl transferase inhibitors might be useful for the development of novel therapeutic strategies for the treatment of MM.
Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis (2002)

Angiogenesis is an essential component of skeletal development and VEGF signaling plays an important if not pivotal role in this process. Previous attempts to examine the roles of VEGF in vivo have been largely unsuccessful because deletion of even one VEGF allele leads to embryonic lethality before skeletal development is initiated. The availability of mice expressing only the VEGF120 isoform (which do survive to term) has offered an opportunity to explore the function of VEGF during embryonic skeletal development. Our study of these mice provides new in vivo evidence for multiple important roles of VEGF in both endochondral and intramembranous bone formation, as well as some insights into isoform-specific functions. There are two key differences in vascularization of developing bones between wild-type and VEGF(120/120) mice. VEGF(120/120) mice have not only a delayed recruitment of blood vessels into the perichondrium but also show delayed invasion of vessels into the primary ossification center, demonstrating a significant role of VEGF at both an early and late stage of cartilage vascularization. These findings are the basis for a two-step model of VEGF-controlled vascularization of the developing skeleton, a hypothesis that is supported by the new finding that VEGF is expressed robustly in the perichondrium and surrounding tissue of cartilage templates of future bones well before blood vessels appear in these regions. We also describe new in vivo evidence for a possible role of VEGF in chondrocyte maturation, and document that VEGF has a direct role in regulating osteoblastic activity based on in vivo evidence and organ culture experiments.
Effect of activated charcoal on aspirin absorption in man Part I (1972)

The effect of activated charcoal (AC) on the gastrointestinal absorption of aspirin teas determined quantitatively in adult volunteers from the amount of total salicylates excreted in the urine. If administered promptly and in sufficient quantity, AC has a significant inhibitory effect on the absorption of aspirin from solution, conventional tablets, enteric coated tablets, and sustained‐release tablets. This effect is increased with an increaiing dose of AC, decreased as the time interval between aspirin and AC administration increases, and decreased by the presence of food in the gastrointestinal tract. There is appreciable desorption of aspirin from AC in the gastrointestinal tract, and therefore, it is necessary to use relatively large doses of the adsorbent in the initial treatment of accidental aspirin poisoning. The efficacy of AC increases with increasing dose at a constant aspirin‐AC dose ratio of 1:10. AC will reduce aspirin absorption even if administered three hours after mpirin ingestion, provided that the drug is still in the gastrointestinal tract at that time.
Direct Quantification of DNA Base Composition by Surface-Enhanced Raman Scattering Spectroscopy (2016)

Design of ultrasensitive DNA sensors based on the unique physical properties of plasmonic nanostructures has become one of the most exciting areas in nanomedicine. However, despite the vast number of proposed applications, the determination of the base composition in nucleic acids, a fundamental parameter in genomic analyses and taxonomic classification, is still restricted to time-consuming and poorly sensitive conventional methods. Herein, we demonstrate the possibility of determining the base composition in single- and double-stranded DNA by using a simple, low-cost, high-throughput, and label-free surface-enhanced Raman scattering (SERS) method in combination with cationic nanoparticles.
Effects of opioid peptides on neural control of renal function in spontaneously hypertensive rats. (1990)

The aims of the present study were to examine the effects of opioid receptor agonists and antagonists on the renal vascular (renal blood flow) and tubular (urinary sodium excretion) responses to renal nerve stimulation and norepinephrine in anesthetized spontaneously hypertensive rats (SHR). Graded frequency renal nerve stimulation (0.5-4.0 Hz) and doses of norepinephrine (10-80 ng/kg) produced frequency and dose-dependent decreases in renal blood flow. The renal vasoconstrictor responses were not altered by intravenous infusion of the opioid receptor agonists methionine enkephalin (mu and delta, 75 micrograms/kg/min) or U-50488H (kappa, 20 micrograms/kg/min) or administration of the opioid receptor antagonist naloxone (1 mg/kg i.v.). The antinatriuretic response to low frequency (less than 1.0 Hz) electrical renal nerve stimulation was prevented by naloxone but not affected by methionine enkephalin administration without changes in glomerular filtration rate or effective renal plasma flow. These studies suggest that endogenous opioid receptor mechanisms are involved in the increased renal tubular sodium reabsorption response to low frequency renal nerve stimulation but not in the renal vasoconstrictor response to either renal nerve stimulation or norepinephrine. This might occur by facilitation of the renal nerve terminal release, the direct renal tubular action, or both, of norepinephrine to influence renal tubular sodium reabsorption.
Application of wavelets in estimating dip angles and conductivities of Earth formation (2004)

Earth formations can be modeled as a layered medium with each layer having its own dip angle and conductivity. In a typical exploration environment, a wellbore (about 15 to 30 cms in diameter) is drilled to a depth that may extend to a few kilometers. Formation properties are measured using a sensor that moves along the wellbore trajectory. The sensor is remotely controlled from the surface. Formation resistivity is an important property, which is measured by a sensor consisting of several transmitters and receivers and operating at a frequency of a few MHz. Estimating dip angles provides valuable information in positioning the wellbore trajectory. We present a novel method for estimating dip angles and formation properties using a wavelet-based processing of well log data in conjunction with an inversion method.
The Integrative Conjugative Element clc (ICEclc) of Pseudomonas aeruginosa JB2 (2018)

Integrative conjugative elements (ICE) are a diverse group of chromosomally integrated, self-transmissible mobile genetic elements (MGE) that are active in shaping the functions of bacteria and bacterial communities. Each type of ICE carries a characteristic set of core genes encoding functions essential for maintenance and self-transmission, and cargo genes that endow on hosts phenotypes beneficial for niche adaptation. An important area to which ICE can contribute beneficial functions is the biodegradation of xenobiotic compounds. In the biodegradation realm, the best-characterized ICE is ICEclc, which carries cargo genes encoding for <i>ortho</i>-cleavage of chlorocatechols (<i>clc</i> genes) and aminophenol metabolism (<i>amn</i> genes). The element was originally identified in the 3-chlorobenzoate-degrader <i>Pseudomonas knackmussii</i> B13, and the closest relative is a nearly identical element in <i>Burkholderia xenovorans</i> LB400 (designated ICEclc-B13 and ICEclc-LB400, respectively). In the present report, genome sequencing of the <i>o</i>-chlorobenzoate degrader <i>Pseudomonas aeruginosa</i> JB2 was used to identify a new member of the ICEclc family, ICEclc-JB2. The cargo of ICEclc-JB2 differs from that of ICEclc-B13 and ICEclc-LB400 in consisting of a unique combination of genes that encode for the utilization of <i>o</i>-halobenzoates and <i>o</i>-hydroxybenzoate as growth substrates (<i>ohb</i> genes and <i>hyb</i> genes, respectively) and which are duplicated in a tandem repeat. Also, ICEclc-JB2 lacks an operon of regulatory genes (<i>tciR-marR-mfsR</i>) that is present in the other two ICEclc, and which controls excision from the host. Thus, the mechanisms regulating intracellular behavior of ICEclc-JB2 may differ from that of its close relatives. The entire tandem repeat in ICEclc-JB2 can excise independently from the element in a process apparently involving transposases/insertion sequence associated with the repeats. Excision of the repeats removes important niche adaptation genes from ICEclc-JB2, rendering it less beneficial to the host. However, the reduced version of ICEclc-JB2 could now acquire new genes that might be beneficial to a future host and, consequently, to the survival of ICEclc-JB2. Collectively, the present identification and characterization of ICEclc-JB2 provides insights into roles of MGE in bacterial niche adaptation and the evolution of catabolic pathways for biodegradation of xenobiotic compounds.
A Possible Relation of the <i>Helicobacter pylori pfr</i> Gene to Iron Deficiency Anemia? (2001)

The mutation in the pfr gene did not relate with the clinical phenotype, iron deficiency anemia. Further studies are needed on the aspects of host side or other complex factors to elucidate the mechanisms by which the H. pylori infection might lead to iron deficiency anemia.
Valorisation technologique des céréales tropicales. Contrat CEE STDII (1993)

Ce rapport, divisé en 3 volumes, rend compte de la recherche menée sous contrat CCE STDII. Le projet s'articule autour de 5 sous-programmes : 1. Caractéristiques technologiques et culinaires des pâtes de sorgho et de maïs; 2. Qualités culinaires des brisures de maïs; 3. Fabrication de pâtes alimentaires de céréales tropicales; 4. Fabrication de tortillas en Afrique; 5. Procédé de fabrication mécanisée de couscous de céréales tropicales
New ligands for asymmetric diethylzinc additions to aromatic aldehydes, demonstrating substrate-dependent nonlinear effects (2002)

The development of several aziridine-based ligands for the asymmetric addition of diethylzinc to a selection of aromatic aldehydes is described. Positive nonlinear effects were observed, and shown to display substrate dependency.
Factors predicting the probability of relapse after discontinuation of migraine preventive treatment with topiramate (2010)

Relapse after topiramate discontinuation in migraine prophylaxis appears to be unaffected by patient characteristics or baseline migraine frequency.
A sol-gel method for preparing oriented YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7- delta</sub>films on silver substrates (1991)

YBa2Cu3O7- delta (YBCO) superconducting films on polycrystalline silver substrates have been fabricated using a sol-gel/spray pyrolysis method. The sol-gel precursor is composed of yttrium, barium and copper acetates that are dissolved in a minimum amount of water and partially gelled using ethanolamine. Silver substrates were heated to 300 degrees C before spray-coating with the precursor solution. Intermittent treatment of films at 550 degrees C in air between spray coats resulted in dense films. Subsequently, the YBCO films were sintered between 850 and 950 degrees C and oxygen annealed on cool down. Film thicknesses of 1-3 mu m were obtained and were highly oriented with the c axis perpendicular to the silver surface. Critical current densities (Jc) of 200-500 A cm-2 have been measured at 77 K and no applied magnetic field; higher Jc values have been measured on films with many pin holes, which appear to increase the number of oxygen entry points into the oriented films. The Jc rapidly decreases in magnetic field, which indicates that transport properties are dominated by weak-link behaviour.
Thermogravimetrische Untersuchungen. IV. Notiz über den Auftrieb bei thermogravimetrischen Messungen (1960)

Abstract Es wird auf einen Auftriebseffekt bei thermogravimetrischen Messungen hingewiesen, dessen Ursprung auf die Wärmestrahlung zurückzuführen ist. Dieser Effekt kann durch einfache apparative Änderung umgangen werden.
Hybrid Helix Metamaterials for Giant and Ultrawide Circular Dichroism (2016)

Circular polarization-resolved imaging and spectroscopy have versatile applications ranging from astronomy and biological and biomedical studies to remote sensing. To achieve real-time imagery with high contrast and rich information, integratable circular polarizers with high extinction ratios, broad operation bandwidths, and low insertion loss are urgently desired, while to our knowledge no structures proposed previously can balance these three vital parameters. In this paper, a concept of a hybrid helix metamaterial has been proposed to achieve ultrawide and giant circular dichroism with low insertion loss simultaneously. By coupling the localized and delocalized resonant modes, a broad and strong blocking band for unselected polarization can be realized with a pencil-like configuration. A giant extinction ratio of 5.9 × 105 can be obtained with a six-pitch hybrid single-helix array, which is almost 7 times larger than the best result reported by Behera et al. in 2015. A very high average extinction ratio of 8.5 × 103 is achieved in the operation band of 3.5–9.5 μm, which is due to an average transmittance as low as 0.2% for the unselected polarizations. More importantly, the top tapered part well-matches the impedance and contributes to a high average transmittance of 72% in the whole range. On the basis of the general scalablility, the validity of such a concept is demonstrated experimentally in the microwave range. The experimental results agree well with theoretical ones. The proposed concept can also be broadly extended to other chiral metamaterial systems for the design of novel high-performance circular polarizers.
Immunopathology of vesicular cutaneous lupus erythematosus in the rough collie and Shetland sheepdog: a canine homologue of subacute cutaneous lupus erythematosus in humans (2004)

Clinical and histological features of an erosive disease in the rough collie and Shetland sheepdog are most consistent with a vesicular variant of cutaneous lupus erythematosus (VCLE). This paper reports the immunopathological findings of canine VCLE using samples from 17 affected dogs. Lesional skin sections were stained with monoclonal antibodies specific for CD3 (11 dogs) or a panel of monoclonal antibodies specific for leukocyte antigens (two dogs). Apoptotic cells were detected using the TUNEL method in 12 cases. Direct (14 dogs) and indirect immunofluorescence tests (five dogs) were also performed. Circulating antibodies to extractable nuclear antigens (ENA) were surveyed in 11 dogs by immunoblotting and ELISA. The predominant cells at the dermal-epidermal interface were identified as CD3(+) T lymphocytes expressing CD4 or CD8 and CD1(+) dendritic antigen presenting cells. In 7/12 dogs (58%), apoptosis of basal keratinocyte nuclei was present. Up-regulation of MHCII and ICAM-1 was observed on basal keratinocytes from the two dogs examined. Direct immunofluorescence revealed deposition of immunoglobulins bound to the cytoplasm of keratinocytes (6/14 dogs; 43%), to the dermal-epidermal junction (7/14 dogs; 50%), or to superficial dermal venules (13/14 dogs; 93%). Circulating IgG auto-antibodies targeting one or more ENA were detected in nine (82%) and eight (73%) of 11 dogs by immunoblotting and ELISA, respectively. These auto-antibodies recognized Ro/SSA and/or La/SSB in four (36%) and six (55%) of 11 dogs respectively by these two methods. Altogether, results of these studies provide evidence supporting the hypothesis that canine VCLE is an immunological homologue of subacute cutaneous lupus erythematosus in humans.