gebhart/patrepeval huggingface dataset:
Improving workforce scheduling using artificial neural networks model (2017)

This paper demonstrates a decision support tool for workforce planning and scheduling. The research conducted in this study is oriented on batch type production typical for smaller production systems, workshops and service systems. The derived model in the research is based on historical data from Public utility service billing company. Model uses Artificial Neural Networks (ANN) fitting techniques. A set of eight input indicators is designed and two variants were tested in the model with two different outputs. Several comprehensive parameter setting experiments were performed to improve prediction performances. Real case studies using historic data from public weather database and communal consolidated billing service show that it is difficult to predict the required number of servers-workers in front office. In a similar way, this model is adequate for complex production systems with unpredictable and volatile demand. Therefore, manufacturing systems which create short cycle products, typical for food processing industry, or production for inventory, may benefit of the research presented in this paper. ANN simulation model with its unique set of features and chosen set of training parameters illustrate that presented model may serve as a valuable decision support system in workforce scheduling for service and production systems.
Update on New Antivirals Under Development for the Treatment of Double-Stranded DNA Virus Infections (2010)

All the currently available antiviral agents used in the treatment of double-stranded (ds) DNA viruses, with the exception of interferon-α, inhibit the same target, the viral DNA polymerase. With increasing reports of the development of resistance of herpes simplex virus (HSV), cytomegalovirus (CMV), and hepatitis B virus (HBV) to some of these drugs, new antiviral agents are needed to treat these infections. Additionally, no drugs have been approved to treat several DNA virus infections, including those caused by adenovirus, smallpox, molluscum contagiosum, and BK virus. We report the status of 10 new antiviral drugs for the treatment of dsDNA viruses. CMX-001 has broad activity against dsDNA viruses; 3 helicase-primase inhibitors, maribavir, and FV-100 have activity against certain herpesviruses; ST-246 inhibits poxviruses; GS-9191 inhibits papillomaviruses; and clevudine and emtricitabine are active against HBV. Most of these drugs have completed at least phase I trials in humans, and many are in additional clinical trials.
DETERMINATION OF CORONARY BLOOD FLOW INDEX BY EXTERNAL SCINTILLATION DETECTION. (1963)

Normal subjects and patients with coronary disease were studied by simultaneous detection of the passage of a radroactive bolus through the heart, the brachial or femoral artery, and the brain. In normal subjects the arterial and brain curve downslopes are similar to each other and are steeper than the heart downslopes. The delay in the heart downslopes is due to coronary radioactivity interposed between the heart cavities and the detector. In coronary patients the three downslopes are similar. Values were established for the coronary flow index (CFI) in normal maies, in normal females, and in patients wrth myocardial infarction. In seven normal individuals with abnormally low CFI subsequent determinations after administrations of reserprne were normal. No modification was recorded in infarct patients. These clinical observations are in accord with thc experiments in animals and theoretical analyses which demonstrate that the ratio of these downslopes is an index of coronary blood flow. (auth)
Coordination layer control and decision making for automated ground vehicles (2002)

This paper is to set up a mathematical model for coordination control and decision making for automated highway system (AHS). The main function of the coordination manager is to coordinate all the maneuvers of each vehicle in a section of AHS such that they are performed coherently, safely and efficiently. A hybrid system model is used to unify both coordination layer and regulation layer. The upper level corresponding to the coordination layer is a programming problem which is to generate discrete optimal solution. Each solution determines some parameters of a reference trajectory of a specified maneuver for lower level control system (regulation layer). It decides when and where to execute the maneuver. The regulation layer is driven by the coordination layer command to the execute lower level control (throttle and brake) comes out of a feedback loop.
Probing Substrate Binding Site of the Escherichia coli Quinol Oxidases Using Synthetic Ubiquinol Analogues (1996)

Substrate binding sites of the Escherichia coli bo- and bd-type quinol oxidases were probed with systematically synthesized ubiquinol analogues. The apparent Km values of ubiquinol-2 derivatives to the bo-type enzyme were much lower than that of the corresponding 6-n-decyl derivatives. The isoprenoid structure is less hydrophobic than the saturated n-alkyl group with the same carbon number; therefore, the native isoprenoid side chain appears to play a specific role in quinol binding besides simply increasing hydrophobicity of the molecule. The Vmax values of 2-methoxy-3-ethoxy analogues were greater than that of 2-ethoxy-3-methoxy analogues irrespective of the side chain structure. This result indicates not only that a methoxy group in the 2-position is recognized more strictly than the 3-position by the binding site but also that the side chain structure does not affect binding of the quinol ring moiety. Systematic analysis of the electron-donating activities of the analogues with different substituents in the 5-position revealed that the 5-methyl group is important for the activity. In the parallel studies with the bd-type enzyme, we obtained similar observations except that almost all quinol analogues, but not ubiquinol-1, elicited a remarkable substrate inhibition at higher concentrations. These results indicate that the two structurally unrelated terminal oxidases share common structural properties for the quinol-oxidation site.
Doxepin kinetics (1978)

The kinetics of doxepin (DOX) hydrochloride were studied in 7 volunteers after the oral administration of 75 mg. Peak plasma concentrations of DOX ranged from 8.8 to 45.8 ng/ml and were reached within 4 hr. The disappearance of DOX was biphasic and followed first-order kinetics. The mean DOX half life (t1/2) was 16.8 hr and in individuals ranged from 8.2 to 24.5 hr. The mean apparent volume of distribution was 20.2 L/kg and ranged from 9.1 to 33.3 L/kg. The estimated first-pass metabolism of DOX ranged from 55% to 87% of the oral dose assuming complete absorption. Significant quantities of the metabolite desmethyldoxepin (DMD) were produced. Peak levels of DMD ranged from 4.8 to 14.5 ng/ml and were reached between 2 and 10 hr after administration. The mean t1/2 of DMD was 51.3 hr and in individuals ranged from 33.2 to 80.7 hr. There was no correlation between the DOX and DMD t1/2s. The amount of DMD produced correlated with the plasma concentration of DOX and appears to explain the correlation between the steady-state concentrations of DOX and DMD in patients given DOX.
Effects of Dextran on the Molecular Structure and Tensile Behaviour of Human Fibrin (1976)

Characteristic changes induced by dextran during the conversion of fibrinogen to fibrin have previously been shown to be associated with profound alterations in morphology of fibrin. However, whether dextran is incorporated into the fibrin molecule and whether morphological changes are associated with alterations in mechanical behaviour of formed fibrin was unclear. The investigations described show that the fibrin made in the presence of dextran has a shortened syneresis time, a lowered modulus of elasticity, an increased elongation and diminished ultimate strength at break. The molecular composition of fibrin clots remains unaltered despite the altered mechanical properties and morphological changes. Furthermore, dextran is not incorporated into the fibrin structure in any appreciable quantity. It is suggested that these several effects of dextran on clot morphology, tensile behaviour and kinetics of fibrin formation arise from increased forces of attraction between fibrin molecules such that fibrin chains are held together by weak secondary cross-links rather than by stronger primary cross-links which are hidden within the thicker fibrin chain bundles.
Kinetic Enzymatic Method for Determining Serum Creatinine (1975)

Creatinine amidohydrolase is used to measure serum creatinine in a totally enzymatic procedure. Creatine, produced by hydrolysis, is acted upon by creatine kinase, and then by pyruvate kinase and lactate dehydrogenase, to result in a change in absorbance at 340 nm. The amount of creatinine present is related to the rate of change in A340 and is determined from a standard curve. Absorbance and concentration are linearly related to 100 mg/liter and only 250 mul of serum is required. At 1.0 g/liter, heparin, oxalate, citrate, ethylenediaminetetraacetate, ascorbate, or glucose had no significant effect on the accurate determination of creatinine; higher concentrations (30 g/liter) had inhibitory effects on the test. Analytical recovery of creatinine added to either normal or abnormal sera averaged 102%. When results of this procedure and of the standard direct Jaffé test were compared, the latter were significantly higher. Unlike the Jaffé method, the present method of determining creatinine is rapid (about 10 min per test), subject to few or no interfering substances, and requires no serum deproteinization.
Effect of biodiesel‐derived waste glycerol impurities on biomass and 1,3‐propanediol production of <i>Clostridium butyricum</i> VPI 1718 (2010)

Aim of the present study was to assess and evaluate the impact of various kinds of impurities of biodiesel-derived raw glycerol feedstock, upon microbial growth and 1,3-propanediol (1,3-PDO) production by Clostridium butyricum. Preliminary trials in 200-mL anaerobic bottles revealed that the presence of NaCl at a concentration of 4.5% (w/w of glycerol) in growth medium imposed an evident inhibitory effect, in contrast with phosphoric salts. However, the application of NaCl at elevated quantities during batch bioreactor experiments [up to 30% (w/w of glycerol)], did neither affect the microbial growth, nor the 1,3-PDO production. Moreover, when oleic acid was added into the growth medium at 2% (w/w of glycerol), a total preclusion of the strain was observed. In order to further investigate whether the nature of oleic acid itself or the presence of the double bond induced the inhibitory phenomenon, stearic acid was added into the medium at the same concentration (2%, w/w, of glycerol). Indeed, no inhibitory effect was observed in the fermentor, suggesting that the presence of the double bond may play a key role in the growth behavior of the microorganism. Finally, methanol effect was tested in batch and continuous bioreactor operations. Interestingly enough, the alcohol addition did not affect the microbial bioconversion of glycerol into 1,3-PDO, even when imposed at relatively high concentrations (10%, w/w, of glycerol) in batch-bioreactor operations. In continuous experiments, methanol was added when steady state had been achieved, and although in one case high concentration was added into the chemostat (5 g/L), the system re-obtained a steady state without indications of negative effect upon biomass production due to the alcohol.
An Electrically Small Frequency Reconfigurable Antenna With a Wide Tuning Range (2011)

An electrically small frequency-reconfigurable antenna with a very wide tuning band is proposed. Three varactor diodes are used to achieve the tunable capacitance. With a modifled feeding structure, the measured tuning range of the fabricated antenna reaches from 457.5 to 894.5 MHz, and the tuning band enhancement is also explained through an equivalent circuit analysis.
Fiber optic reference guide : a practical guide to the technology (1999)

Introduction * A History of Fiber Optic Technology * Fiber Optic Fundamentals: Advantages of Fiber Optics * Optical Fiber *Fiber Optic Cables * Light Emitters * Light Detectors* Interconnection Devices: Connector Evolution Other Passive Devices* System Design Considerations* Fiber Optic Applications * Video Over Fiber * Data Over Fiber * Testing & Measurement Techniques * Future Trends * Appendices:
Beyond map view: teaching the conceptualisation and visualisation of geology through 3D and 4D geological models (2012)

The ability to visualise geological structures in three dimensions is an important skill developed during an undergraduate student's geology course. These visualisation skills include the ability to conceptualise a 3D model from a 2D geological map. A further higher order skill is to ‘see’ how 3D geological structures develop through time. To assist undergraduate students to improve competence in these key visualisation skills, and to aid university teachers, we present a series of interactive 3D digital models of geological structures. The geological models can be forward modelled and restored, allowing the user to visualise the formation and evolution of geological structures and relate this to the final model geometry and map pattern.
Biotechnology in Animal Feeds and Animal Feeding (1995)

Partial table of contents: Biotechnology in Animal Feeds and Animal Feeding: An Overview Silage Additives Transgenic Plants with Improved Protein Quality Protected Proteins and Amino Acids for Ruminants Antibacterials in Poultry and Pig Nutrition Microbial Probiotics for Pigs and Poultry Microbial Feed Additives for Pre-Ruminants Transgenic Plants with Improved Energy Characteristics Biotechnology in the Treatment of Animal Manure Feed Additives and Other Interventions for Decreasing Methane Emissions.
The Next Epidemic — Lessons from Ebola (2015)

As the Ebola epidemic fades from the world's attention, we risk missing the opportunity to learn from it. One key lesson is that the world needs a global warning and response system for outbreaks. Bill Gates sketches a vision for such a system.
Towards trustworthy participatory sensing (2009)

Grassroots Participatory Sensing empowers people to collect and share sensor data using mobile devices across many applications, spanning intelligent transportation, air quality monitoring and social networking. In this paper, we argue that the very openness of such a system makes it vulnerable to abuse by malicious users who may poison the information, collude to fabricate information, or launch Sybils to distort that information. We propose and implement a novel trusted platform module (TPM), or angel based system that addresses the problem of providing sensor data integrity. The key idea is to provide a trusted platform within each sensor device to attest the integrity of sensor readings. We argue that this localizes integrity checking to the device, rather than relying on corroboration, making the system not only simpler, but also resistant to collusion and data poisoning. A “burnedin” private key in the TPM prevents users from launching Sybils. We also make the case for content protection and access control mechanisms that enable users to publish sensor data streams to selected groups of people and address it using broadcast encryption techniques. 1
Ética, la academia, y las organizaciones sociales: estudio de caso / Ethics, academy, and civil society organizations: a case study (2015)

La Constitución de la República Oriental del Uruguay señala, en su Artículo 70: “El Estado propenderá al desarrollo de la investigación científica ...”. Sin embargo, la repatriación, a instancias de una organización de descendientes de indígenas autotitulados charrúas (ADENCH) y con apoyo del Parlamento, de los restos del cacique charrúa Vaimaca Perú, muerto en cautividad en Francia en 1833, motivó controversias acerca de si los restos del mismo podían ser estudiados. Esta discusión no fue académica, si bien hubo derivaciones que influyeron sobre otras investigaciones, sino que fue suscitada por dicha organización la cual se opuso al estudio de los restos llegando a interponer varios recursos legales; uno de éstos, que condujo a un juicio, motivó un fallo histórico de un Tribunal de Apelaciones a favor del “interés general” por conocer “sin ataduras, sin secretos y sin misterios, la identidad de nuestro pueblo...”. Sin embargo, y sin que se hiciera mención de dicha sentencia, el Parlamento aprobó posteriormente la Ley 17.767 que prohíbe expresamente la realización de “experimentos y estudios científicos” en los restos de Vaimaca Perú, violando según algunos autores, la propia Constitución y planteando, además de la discordancia entre dos Poderes del Estado, la oposición entre diversos intereses. A partir de estos hechos se propone analizar los valores éticos que subyacen a la investigación, si deben plantearse limitaciones a ésta y de ser así, cuáles, e incluso, cómo se debe normar sobre las mismas.
Cartilage Repair In Vivo: The Role of Migratory Progenitor Cells (2014)

The most common diseases of the joints and its tissues are osteoarthritis and rheumatoid arthritis, with osteoarthritis being anticipated to be the fourth leading cause of disability by the year 2020. To date, no truly causal therapies are available, and this has promoted tissue engineering attempts mainly involving mesenchymal stem cells. The goal of all tissue repairs would be to restore a fully functional tissue, here a hyaline articular cartilage. The hyaline cartilage is the most affected in osteoarthritis, where altered cell-matrix interactions gradually destroy tissue integrity. In rheumatoid arthritis, the inflammatory aspect is more important, and the cartilage tissue is destroyed by the invasion of tumor-like pannus tissue arising from the inflamed synovia. Furthermore, the fibrocartilage of the meniscus is clearly involved in the initiation of osteoarthritis, especially after trauma. Recent investigations have highlighted the role of migratory progenitor cells found in diseased tissues in situ. In osteoarthritis and rheumatoid arthritis, these chondrogenic progenitor cells are involved in regeneration efforts that are largely unsuccessful in diseased cartilage tissue. However, these progenitor cells are interesting targets for a cell-based regenerative therapy for joint diseases.
A participação em grupos como indicador de capital social de adolescentes trabalhadores (2016)

The aim of this study was to evaluate the potential of participation in groups as a single variable to measure the social capital of young workers. We conducted a transverse analytical study with 363 adolescent workers assisted by a Supreme Philanthropic Support Teen by the application of the Integrated Questionnaire for Measuring Social Capital (SC-IQ). We considered two different types of classification of capital stock that were compared by analyzing nearest neighbor interpolation on the questions selected from the survey. It was concluded that participation in groups cannot be considered a good indicator of social capital in the study sample. The friendship was measured by the number of friends, along with trust and collective action aspects are good measures of capital stock.
The chemical form and physiological function of nickel in some Iberian Alyssum species (1981)

The form of nickel in leaves of Iberian subspecies of Alyssum serpyllifolium Desv. was investigated. Subsp. lusitanicum T. R. Dudley and P. Silva (from N.E. Portugal) and subsp. malacitanum Rivas Goday (from Southern Spain) were hyperaccumulators of nickel (>1000 μg/g Ni) whereas their non‐accumulating precursor (subsp. serpyllifolium ) was not. Nickel existed mainly as a water‐soluble polar complex in the vacuoles. Small concentrations of nickel did however exist in cell fractions, particularly in the mitochondria where enzyme systems are located. Gas‐liquid chromatography on the purified nickel complexes showed that this element is associated principally with malic and malonic acids which are present in high concentrations in the hyperaccumulators but not in subsp. serpyllifolium . It is suggested that production of malic acid is a mechanism whereby hyperaccumulators can tolerate unfavourable edaphic factors such as nickel‐rich soils. Presence of nickel in the mitochondria can presumably block the citric acid cycle by deactivating malic dehydrogenase leading to build‐up of malic acid in the vacuoles which could then absorb excess nickel by a complexing reaction and lead to its diffusion back into the vacuoles from the mitochondria, hence unblocking the citric acid cycle. It is postulated that the chemical evidence suggests that the two hyperaccumulators are not conspecific and that subsp. malacitanum should be promoted to full specific rank.
On America's Influence Upon Diplomatic Relations Between China and England from 1949 to 1972 (2001)

The process of establishing diplomatic relations between China and England is long and complicated, in which America plays an important role. After the Second World War, England depended largely on America and always followed the latter in making its policies toward China. This led to the delay of the establishment of relationship between the two countries. This paper tries to make an objective analysis of how America affected diplomatic relations between China and England in three different periods.
Oxalate, formate, formamide, and methanol metabolism in Thiobacillus novellus (1977)

Thiobacillus novellus was able to grow with oxalate, formate, formamide, and methanol as sole sources of carbon and energy. Extensive growth on methanol required yeast extract or vitamins. Glyoxylate carboligase was detected in extracts of oxalate-grown cells. Ribulose bisphosphate carboxylase was found in extracts of cells grown on formate, formamide, and thiosulfate. These data indicate that oxalate is utilized heterotrophically in the glycerate pathway, and formate and formamide are utilized autotrophically in the ribulose bisphosphate pathway. Nicotinamide adenine dinucleotide-linked formate dehydrogenase was present in extracts of oxalate-, formate-, formamide-, and methanol-grown cells but was absent in thiosulfate- and acetate-grown cells.
[Diagnosis and treatment of pancreatic islet cell tumors producing vasoactive intestinal polypeptide (VIPoma)]. (1999)

The incidence of VIPoma is approximately one per 10 million population. Thus in the Czech Republic this rare disease should be diagnosed once per year. The authors present their experience with the diagnosis and treatment of patient born in 1956, who suffered since 1990 from diarrhoea, at first episodically. In 1992-1994 the diarrhoea was profuse, caused dehydration, hypokalaemia and severe metabolic acidosis without an increase of the anion gap. As a result of dehydration the patient developed acute renal insufficiency. Due to hypokalaemia he developed paroxysmal atrial fibrillation. The diagnosis was based on the clinical finding and later confirmed on laboratory examination by a high VIP serum concentration. For treatment of diarrhoea Sandostatin was used. The tumour was located only after a scan with 123I-VIP in the cauda of the pancreas. Scintigraphy with labelled octreotide, similarly as other imaging methods (sono, X-ray and CT) were not effective. In 1994 left-sided hemipancreatectomy was performed. Although the patient was operated four years after the onset of the disease, no secondaries were detected. After surgery the diarrhoea stopped and no further treatment was necessary.