gebhart/patrepeval huggingface dataset:
Isolation, Structure Elucidation, and Synthesis of the Major Anaerobic Bacterial Metabolite of the Dietary Carcinogen 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (meIQ) (1989)

Incubation o f the heterocyclic cooked food mutagen 2-amino-3.4-dimethyl-3H-imidazoL4.5-fjquinoline (MeIQ, 3) w i t h mixed human fecal m i c r o f l o r a under anaerobic conditions y i e l d e d 2-amino-3.6-dihydro-3.4-dimethyl-7H-imidazoL4,5-f~quinolin-7-one(HOMeIQ, 4) as the major detectable metabolite.HOMeIQ (4) was synthesized i n s i x steps from 6-bromo-7-methylquinoline (5).
Analysis & recommendations for a medical engineering department. (1982)

A multi-disciplinary task force convened to examine present and future program needs of the Medical Engineering Department at the North Carolina Memorial Hospital, University of North Carolina School of Medicine. The committee recommended changes that would reduce technician turnover, improve continuing education, increase salaries, improve services for patient care and allow the hospital to comply with the requirements of the Joint Commission on the Accreditation of Hospitals. An important by-product of this study approach led to improved communications and work relations with all departments that receive services from the Medical Engineering Department.
Cell-therapy using microglia to prompt functional recovery after ischemic stroke (2017)

脳梗塞後遺症の機能を回復させる治療法の確立が望まれている．ミクログリアを保護的ミクログリア（M2）に変化させる低酸素低糖刺激（OGD）の条件を決定し，M2-likeミクログリアを亜急性期に投与することで，脳虚血後の機能予後を改善させることが可能かを検証した．初代ミクログリアの培養上清を試料として，血管内皮増殖因子（VEGF），トランスフォーミング増殖因子（TGF-β），およびマトリックス・メタロプロテナーゼ（MMP）-9活性を測定したところ，18時間のOGD後，M2極性となっていることがわかった．さらに，ラット一過性局所脳虚血モデルに対し，虚血7日後，M2-likeミクログリアを投与したところ，虚血中心の辺縁部におけるVEGF，TGF-β，MMP-9の発現は増加し，さらに同部位の血管新生，ペナンブラにおける軸索伸展は，非投与群と比べて促進され，虚血4週間後の機能を回復させた．OGDによりM2化したミクログリアを用いた細胞療法は，従来にない治療戦略になるものと考えられる．
Murine Plasma Cells Secreting More Than One Class of Immunoglobulin Heavy Chain (1977)

Abstract SAMM 368, a plasmacytoma which produces IgA-κ and IgG2b-κ was established in vitro from primary explants or after animal passage. The 9 lines that were established produced both paraproteins. The production of both immunoglobulins by single cells was demonstrated by immunofluorescent staining and cloning. Continuous culture of 3 parent lines for 18 months and 11 cloned lines for periods from 5 to 7 months demonstrated that double production is a stable characteristic of this plasmacytoma. Two single paraprotein-producing varients (IgG2b or IgA) were derived when cells were cultured in the presence of Fungizone. Chromosomal analysis of SAMM 368 indicates that this double producing tumor has a modal number similar to those observed in myelomas producing a single immunoglobulin class.
Structural studies of the motor protein kinesin by image reconstruction and X-ray crystallography (1996)

Kinesin, a microtubule-activated ATPase, is a cytoplasmic motor which moves vesicles or organelles towards the distal end of microtubules. We have expressed several fragments of kinesin head domain in E. coli and used it for structural and biochemical studies of the microtubule-kinesin interaction. Open questions include: (a) Which tubulin subunit binds to kinesin? (b) What is the stoichiometry of binding? (c) How does the decoration by kinesin reveal the underlying microtubule lattice? (d) What is the polmity of the kinesin binding, and that of the tubulin subunits in a microtubule? Stmctural questions were addressed by image reconstmction of opened up microtubule walls decorated with several kinesin constructs, and by X-ray crystallography of the kinesin head domain. The reconstructions of the decorated and two-dimensionally ordered "tubulo-kinesin-complex" yields a low resolution (2nm) picture of how kinesin and Wbulin interact with one another, including the tubulinlattice, binding stoichiometry, and polarity. Altematively, the kinesin head can be induced to form wellordered 3-dimensional crystals suitable for X-ray crystallography. The solution of the structure makes use of single isomorphous replacement including anomalous diffraction at different wavelengths, using a mercury derivative of kinesin. In addition, MAD data were obtained from de1ivatives in which methionines were replaced by seleno-methionines. The interpretation of the electron density will be presented.
Control of the inflammatory response with poly(trolox ester) antioxidant nanoparticles (2012)

Poly(trolox ester) nanoparticles were screened for anti-inflammatory properties on two different rheumatoid arthritis cell lines. Trolox was polymerized to two different molecular weights and formed into nanoparticles, which were added to cultures of interleukin-1β stimulated MH7A synovial fibroblast cells and macrophage-like U937 cells. Poly(trolox ester) nanoparticles effectively reduced the secretion of pro-inflammatory mediators by both cell types.
Le patient transplanté rénal est-il un insuffisant rénal comme les autres ? (2008)

To assess if the renal transplant patient can really be considered as a patient with chronic renal insufficiency, disease progression and outcomes were compared in both groups. At the same stage of chronic kidney disease (CKD), the deterioration of renal function was slower and graft survival was longer in renal transplant patients. Despite slower rates of kidney function decline, overall patient survival was similar between the two groups. Interestingly, stage 3 adjusted mortality rates were greater in kidney transplant recipients, most likely because of the disease burden (history of end-stage renal disease in renal transplant recipients) and immunosuppression. The three major causes of mortality in transplant patients (cardiovascular, infectious and malignant) may present with specific characteristics in transplant patients. Renal transplantation is thus a specific form of CKD, controlled by 3 factors, a single kidney, immunosuppression and the burden of the disease. The general application of the KDOQI and KDIGO guidelines to kidney transplant recipients requires therefore further evaluation.
Comparison of Mammalian Cell Suspension Culture Methods Using Poly(lactic-co-glycolic acid) Nanospheres and Dextran Microcarriers (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Multicarrier orthogonal CDMA signals for quasi-synchronous communication systems (1994)

Proposes a multicarrier orthogonal CDMA signaling scheme for a multiple-access communication system, such as the reverse channel of a cellular network, as an alternative to the multi-user interference cancellation approach. The average variance of cross-correlations between sequences is used as a measure for sequence design. The authors search for sets of sequences that minimize the probability of symbol detection error, given that there is imperfect synchronization among the signals, that is, the signals are quasi-synchronous. Orthogonal sequences based on the Sylvester-type Hadamard matrices (Walsh functions) are shown to provide a significant improvement over the case where a Hadamard (orthogonal) matrix is chosen at random. Computer searches suggest that this set of codes is optimal with respect to the above measure. The issue of chip pulse shaping is investigated. Optimal pulses designed to minimize multiple-access interference in quasi-synchronous systems are obtained for various bandwidths and are shown to provide a large improvement over the raised cosine pulses. A multicarrier signaling scheme is introduced in order to reduce chip level synchronization offsets between the users.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MOLD METABOLITES: 2. THE STRUCTURE OF GRISEOVIRIDIN (1964)

By a combination of selectively reductive and hydrolytic processes the structure of perhydrodethiogriseoviridin diacetate, obtained by Raney nickel reduction of griseoviridin diacetate, has been shown to be that of a macrocyclic lactonic peptide (III). Other hydrolytic and degradative experiments have ascertained the points of attachment of the cysteine moiety and the disposition of the functional groups in the aminodecanoic acid. The remaining three carbon atoms have been shown to be part of an unusual dehydro amino acid fragment, and the totality of this and other evidence has defined the structure of griseoviridin as represented in (XXVII).
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α) (2011)

Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the hydroxylation of proteins and small molecules. Some of these processes are centrally involved in regulation of cellular responses to hypoxia. The ALKBH proteins are a sub-family of 2OG oxygenases that are defined by homology to the Escherichia coli DNA-methylation repair enzyme AlkB. Here we report evidence that ALKBH5 is probably unique amongst the ALKBH genes in being a direct transcriptional target of hypoxia inducible factor-1 (HIF-1) and is induced by hypoxia in a range of cell types. We show that purified recombinant ALKBH5 is a bona fide 2OG oxygenase that catalyses the decarboxylation of 2OG but appears to have different prime substrate requirements from those so far defined for other ALKBH family members. Our findings define a new class of HIF-transcriptional target gene and suggest that ALKBH5 may have a role in the regulation of cellular responses to hypoxia.
Support Effects and Chemical Gradients along the Catalyst Bed in NO<sub><i>x</i></sub> Storage-Reduction Studied by Space- and Time-Resolved In Situ DRIFTS (2009)

Support effects in NOx storage-reduction (NSR) have been investigated by means of space- and time-resolved in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) using Pt−Ba catalysts supported on six different metal oxides (MOx = Al2O3, TiO2, SiO2, CeO2, ZrO2, and Ce0.5Zr0.5O2) and hydrogen as reductant. The NSR performance was significantly influenced by the type of oxide supports. The NOx storage capacity followed the order CeO2 > Ce0.5Zr0.5O2 > Al2O3 > ZrO2 > TiO2 > SiO2, which is in agreement with the basicity of the oxides. In contrast, the rate of NOx reduction showed the reverse order. The study shows that storage and reduction of NOx and spillover processes are influenced by the type of support. As a result of this, the support material also affects the concentration gradients along the catalyst bed which in turn has an effect on the NSR performance. Strong basicity is beneficial for efficient NOx storage during lean periods but decreases the rate of NOx reduction during rich periods by stabilizing surface and bulk nitrates. The high oxygen-storage ability of CeO2 and Ce0.5Zr0.5O2 further decreases the rate of NOx reduction due to the consumption of reductant with the stored oxygen to form water. In practice, there seems to be a trade-off between efficient NOx storage and NOx reduction rate determined by the nature of the support material. In this respect the most widely used catalyst based on γ-alumina as support seems to be a good compromise for achieving efficient storage and fast reduction of NOx. However, CeO2 and Ce0.5Zr0.5O2 have a potential to serve as suitable support materials for efficient NSR catalysts if they are modified to enhance the reduction rate.
Range-Gated Metrology with Compact Optical Head (2008)

This work represents a radical simplification in the design of the optical head needed for high-precision laser ranging applications. The optical head is now a single fiber-optic collimator with dimensions of order of 1 1 2 cm, which can be easily integrated into the system being measured with minimal footprint.
Development of a High Speed Gas Bearing Test Rig to Measure Rotordynamic Force Coefficients (2011)

The use of gas bearings has increased over the past several decades to include microturbines, air cycle machines, and hermetically sealed compressors and turbines. Gas bearings have many advantages over traditional bearings, such as rolling element or oil lubricated fluid film bearings, including longer life, ability to use the process fluid, no contamination of the process with lubricants, accommodating high shaft speeds, and operation over a wide range of temperatures. Unlike fluid film bearings that utilize oil, gas lubricated bearings generate very little damping from the gas itself. Therefore, successful bearing designs such as foil bearings utilize damping features on the bearing to improve the damping generated. Similar to oil bearings, gas bearing designers strive to develop gas bearings with good rotordynamic stability. Gas bearings are challenging to design, requiring a fully coupled thermo-elastic, hydrodynamic analysis including complex nonlinear mechanisms such as Coulomb friction. There is a surprisingly low amount of rotordynamic force coefficient measurement in the literature despite the need to verify the model predictions and the stability of the bearing. This paper describes the development and testing of a 60,000 rpm gas bearing test rig and presents measured stiffness and damping coefficients for a 57 mm foil type bearing. The design of the rig overcomes many challenges in making this measurement by developing a patented, high-frequency, high-amplitude shaker system, resulting in excitation over most of the subsynchronous range.
Taurine deficiency and supplementation in protein malnourished rats (1997)

info:eu-repo/semantics/published
Update Dependencies in the Relational Model (1991)

Abstract : Relational database systems suffer from the lack of a rich update language, In this paper we present the Update Dependency Language which allows the database designer to specify a procedure for each update that is activated when attempts are made to perform the update. Each procedure integrated the update dependencies for an update and provides an operational semantics for the update which is maintained by the system. We provide a formal definition for this language, illustrate its use, and discuss concurrency control issues related to integrating such a language into a database system.
Development of Capacitive Ultrasonic Sensor with Parylene Diaphragm Using Micromachining Technique (2007)

In this paper, we reports the development of a miniaturized capacitive ultrasonic sensor with a Parylene diaphragm using a micromachining technique. Since the polymer diaphragm is flexible and nonbrittle, good sensitivity and durability are expected. Moreover, Parylene has good complementary metal oxide semiconductor (CMOS) compatibility, since it can be deposited at room temperature. Practical sensor devices were fabricated, and their performance was characterized. They can receive an impulsive ultrasonic pulse transmitted by a spark discharge with an open-circuit sensitivity of 0.3 mV/Pa. A well-damped waveform was obtained by setting appropriate acoustic holes. The ranging system using this sensor can detect distances up to 1 m with an error of less than 1 mm. The developed sensor can receive ultrasound from a wide area. The wide directivity could be effective for realizing the omni-directional characteristics of the future arrayed sensor, which contains many of the developed sensors.
Production of interleukin 1beta by human hematopoietic progenitor cells. (1996)

The production of interleukin 1beta (IL-1beta) by human hematopoietic stem/progenitor cells was studied to explore the concept that these cells are not merely responders to stimuli from their microenvironment, but can themselves produce a powerful biomodulator. Cells with a CD34+ CD45RA(lo) CD71(lo) phenotype were purified from human umbilical cord blood and cultured one per well in serum-free medium with a mixture of cytokines. Cells that had divided over 2-5 d to form doublets were identified and the daughter cells were studied individually. 91% (460/506) of daughter cells had clonogenic potential. Analysis of these individual daughter cells by reverse transcription-polymerase chain reaction showed that 29% of them (14/48) were positive for IL-1beta mRNA. One of the cells that was strongly positive for IL-1beta mRNA had a sibling that generated 366,000 cells of multiple lineages after 14 d. IL-1beta converting enzyme mRNA, which is necessary to produce IL-1beta, was also detected by reverse transcription-polymerase chain reaction at the single-cell level. Moreover, enzyme immunoassay for mature secreted IL-1beta in culture supernatants demonstrated the production of IL-1beta protein by these cells. This was confirmed by fluorescent immunostaining of the cells for human IL-1beta which showed a significant portion of positive cells. Taken together, the results demonstrate the capacity of early hematopoietic cells to synthesize IL-1beta. The capacity of human hematopoietic stem/progenitor cells to produce IL-1beta may be involved in regulation of their proliferation and differentiation under certain circumstances and dysregulation of this process may be modified in leukemogenesis.
Nomenclature and terminology of inositol phosphates: clarification and a glossary of terms. (2006)

This chapter provides an overview of inositol phosphate nomenclature and a glossary of terms that are consistently deployed throughout this book. The myo-inositol phosphates and their accepted abbreviations are tabulated, and the chemical structure of the nine stereoisomeric forms of inositol are illustrated.
Early Upper-Extremity Prothetic Fit in Patients with Burns (1991)

Patients with upper-extremity amputations necessitated by burn injury have frequently faced delays in prosthetic fit. At the Regional Medical Center, Memphis, Tennessee, seven patients required amputations because of burns. These injuries were electrical in four cases, thermal and crush in one case, thermal in one case, and steam and crush in one case. Five patients had below-elbow amputations, one had a bilateral below-elbow amputation, and one had a bilateral above-elbow amputation. All patients were fitted with prostheses within 30 days of the last definitive surgery on the amputated extremity. All patients continued to wear a prosthesis and no patient exhibited skin breakdown. Patients returned to independence with self care within 2 weeks and to preamputation activities within an average of 2.5 months.
Preservation of the NADPH redox system is not responsible for the protective effects of ischemic preconditioning (2011)

Quarrie, Ricardo MD; Lee, Daniel S. BSc; Cramer, Brandon; Erdahl, Warren PhD; Pfeiffer, Douglas R. PhD; Zweier, Jay L. MD; Crestanello, Juan A. MD Author Information
Induction of new bone by allogeneic demineralized bone matrix combined to bioactive glass composite in the rat. (1993)

Allogeneic diaphyseal demineralized bone matrix (DBM) cylinders containing bioactive glass rods were implanted for 4 and 8 weeks in the abdominal muscle wall of rats. DBM without glass served as control. The results suggest that new bone induction by DBM was accelerated by the presence of bioactive glass implants. However, the bone formation induced by DBM on the glass surface was relatively small. The biocompatibility of the glass was verified by the absence of adverse cellular reactions in the interface region between glass and bone. The method used provides a simple and fast means of exploring the characteristics of potential bone substitutes.
Practical Bayesian tomography (2016)

In recent years, Bayesian methods have been proposed as a solution to a wide range of issues in quantum state and process tomography. State-of-the-art Bayesian tomography solutions suffer from three problems: numerical intractability, a lack of informative prior distributions, and an inability to track time-dependent processes. Here, we address all three problems. First, we use modern statistical methods, as pioneered by Husz\'ar and Houlsby and by Ferrie, to make Bayesian tomography numerically tractable. Our approach allows for practical computation of Bayesian point and region estimators for quantum states and channels. Second, we propose the first priors on quantum states and channels that allow for including useful experimental insight. Finally, we develop a method that allows tracking of time-dependent states and estimates the drift and diffusion processes affecting a state. We provide source code and animated visual examples for our methods.
Spectral Line-Diode Registry Effects with Photodiode Array Detectors (1986)

A limitation of photodiode array detectors for spectroscopic intensity measurements relates to the spacing of the diodes and the errors generated when a spectral line is not in exact registry with the diode or diodes from which its intensity is being measured. These misregistry intensity errors, which may be as high as 25 to 30%, are documented for a range of spectral bandwidths and for single diode (pixel) intensities and multiple diode summations of intensities.
Asymptomatic Carriage of Sequence Type 398, <i>spa</i> Type t571 Methicillin-Susceptible Staphylococcus aureus in an Urban Jail: a Newly Emerging, Transmissible Pathogenic Strain (2013)

Sequence type 398 (ST398) Staphylococcus aureus, frequently carried by livestock, has caused severe human infections and often carries transmissible antibiotic resistance genes. Among methicillin-susceptible S. aureus isolates colonizing Dallas County Jail detainees, 13.2% were ST398, spa type t571, and were genetically similar to human colonization isolates from New York, Chicago, and the Dominican Republic.
THE TERRAIN-VEHICLE PROGRAMS OF THE US ARMY ENGINEER WATERWAYS EXPERIMENT STATION (1964)

The report presents a brief resume of soil trafficability research performed by the U.S. Army Engineer Waterways Experiment Station and describes test methods and facilities.
Effect of Instantaneous Controlled Pressure Drop on the glucosinolate content of rapeseed (2007)

International audience
Monitored Displacements of Unique Geosynthetic-Reinforced Soil Bridge Abutments (2002)

A geosynthetic-reinforced soil (GRS) system was constructed to support the shallow footings of a two-span bridge and the approaching roadway structures. Construction of this system, the Founders/Meadows bridge abutments, was completed in 1999 near Denver, Colorado, USA. This unique system was selected with the objectives of alleviating the “bump at the bridge” problem often noticed when using traditional deep foundations, allowing for a small construction working area, and facilitating construction in stages. The primary focus of the paper is to evaluate the deformation response of this structure under service loads based on displacement data collected through surveying, inclinometer, strain gages, and digital road profiler. The overall short- and long-term performance of the Founders/Meadows structure was excellent, suggesting that GRS walls are a viable alternative to support both bridge and approaching roadway structures.
Relations among privacy notions (2011)

This article presents a hierarchy of privacy notions that covers multiple anonymity and unlinkability variants. The underlying definitions, which are based on the idea of indistinguishability between two worlds, provide new insights into the relation between, and the fundamental structure of, different privacy notions. We furthermore place previous privacy definitions concerning group signature, anonymous communication, and secret voting systems in the context of our hierarchy; this renders these traditionally disconnected notions comparable.