gebhart/patrepeval huggingface dataset:
Frequency and phenotypic spectrum of ataxia with oculomotor apraxia 2: a clinical and genetic study in 18 patients (2004)

Ataxia with oculomotor apraxia type 2 (AOA2) is a newly described autosomal recessive cerebellar ataxia (ARCA) defined by genetic location to 9q34 of three families sharing gait ataxia, oculomotor apraxia and/or elevated alpha-foetoprotein (AFP) levels. We have evaluated 77 families with progressive non-Friedreich ARCA and have identified six families with a phenotype suggestive of AOA2. Linkage was confirmed in all six families, with a maximal lod score of 5.91 at D9S1830. We report the first detailed phenotypic study, including neuropsychological, oculographic and brain imaging investigations, in the largest series of AOA2 patients yet recruited. The mean age at onset was 15.1 +/- 3.8 years. Sensory motor neuropathy (92%) and choreic or dystonic movements (44%) were frequent. Oculomotor apraxia was observed in 56% of patients and characterized by increased horizontal saccade latencies and hypometria. AFP levels were elevated in 100% of the families, making it a useful biological marker. This study shows for the first time that AOA2 can be found in Europe, North Africa and the West Indies, and its relative frequency represents approximately 8% of non-Friedreich ARCA, which is more frequent than ataxia telangiectasia and ataxia with oculomotor apraxia type 1 (AOA1), in our series of adult patients. In adults, AOA2 may be, therefore, the most frequent cause of ARCA identified so far, after Friedreich's ataxia.
Soil Treatment with Fungal Agents for Control of Apothecia of Sclerotinia sclerotiorum in Bean and Pea Crops (2000)

A two-year field study was conducted to determine the effects of soil treatment with four mycoparasites and one antagonist on production of apothecia of Sclerotinia sclerotiorum under the canopy of dry bean and dry pea. Among the five species of fungi assessed, Coniothyrium minitans and Talaromyces flavus were the most effective agents for reducing carpogenic germination of sclerotia of S. sclerotiorum in bean and pea crops, whereas Tricothecium roseum and Trichoderma virens were effective only in bean, and Epicoccum purpurascens was ineffective for both crops. Treatment with C. minitans significantly reduced formation of apothecia of S. sclerotiorum in bean and pea. This study suggests that, under Canadian Prairie conditions, soil treatment with mycoparasites such as C. minitans can be an effective measure for reducing the production of ascospores, which are the primary source of inoculum for white mold of bean and sclerotinia blight of pea.
Solids and Sand Monitoring – An Overview (2000)

Abstract From the earliest days of oil and gas production, solids mixed in with the flowing medium have caused problems. The origins of this “sand” or solids in the flow can be attributed to formation particles, corrosion products, scale, solids introduced into the well such as drilling mud and frac sand, and any other solids. With the newer methods of horizontal well drilling and completion, the probability of sand flow is much higher today. Because of larger finds the velocities of today often surpass 100 feet per second. This velocity causes erosion. In addition, the financial payback time for individual wells and platforms is shorter than in the past. Therefore more product must be attained in a shorter time frame exacerbating the sand problem. If the production of formation sand is not minimized formation damage can occur, downhole well equipment can be damaged, surface production equipment can be damaged and plugging of monitors can occur. The damage to the equipment alone can be expensive and downtime costs add significantly to the overall cost of sand related failures. The possibility of failures due to sand erosion can be catastrophic especially when produced fluids and gases escape into the atmosphere. In order to control the flow of solids it is necessary to have an early indication of when the solids flow begins or if sudden changes occur in the flow patterns. This paper will give a brief overview of the history of sand monitoring and the latest acoustic technology available for the detection of solids flow.
The Preparation of Carbodiimides, Isocyanates, and Isothiocyanates by Metal Ion-assisted Elimination of Mercaptan<sup>1,2</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Carbodiimides, Isocyanates, and Isothiocyanates by Metal Ion-assisted Elimination of Mercaptan1,2Arthur F. Ferris and Beverly A. SchutzCite this: J. Org. Chem. 1963, 28, 1, 71–74Publication Date (Print):January 1, 1963Publication History Published online1 May 2002Published inissue 1 January 1963https://doi.org/10.1021/jo01036a014RIGHTS & PERMISSIONSArticle Views358Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (596 KB) Get e-Alertsclose Get e-Alerts
CERN fire fighters roll out in style (2011)

On Thursday, 20 October, CERN fire fighters celebrated the arrival of a new equipment transport truck. Measuring 13m3 and weighing 2.5 tonnes, the truck can carry several types of response materials in the event of chemical or radiological accidents, pollution incidents or floods. It can also pull trailers carrying fire extinguishers and oxygen masks. "Despite its size, this vehicle is extremely practical and flexible, and it can be put to work quickly and easily,” says Patrick Berlinghi, logistics officer for the Fire Brigade. “It is equipped with a rear-view camera and lighting on the rear and the side. It can also be loaded and unloaded very quickly, as it takes only 15 seconds to lower the truck box and open the doors! "
On the Imagery and Connotation of the Moon in Li Bai's Poems (2003)

The legend, which says that the great poet Li Bai was born for his mother's dream of Venus and in his later years he drunkenly went into the river to seek the moon and died, shows the poet had an unquenchable passion for the moon. Among his 1000 poems, 336 are concerned with the moon imagery; more than 400 have some relations with the moon. In his poems, imagery of the moon is so rich; the connotation is so profound; the technique of expression is so outstanding; the artistry is so superb, that no other poets could parallel him. Li Bai had a great effect on the other ancient poets'(such as Liu Yuxi,Su Shi) chant poems on the moon. He also made a great contribution to the formation and development of the Chinese culture about the moon.
A Matrix Metalloproteinase-9 Activation Cascade by Hepatic Stellate Cells in Trans-differentiation in the Three-dimensional Extracellular Matrix (2007)

Hepatic stellate cells (HSCs) undergo myofibroblastic trans-differentiation in liver fibrogenesis. We previously showed that dual stimulation with three-dimensional type-I collagen and interleukin-1 (IL-1) synergistically induces HSC trans-differentiation in a manner dependent on the activation of matrix metallopreinase-9 (MMP-9). The present study is aimed to determine the mechanism of MMP-9 activation in this model. The pro-MMP-9-converting activities expressed by trans-differentiating HSCs are characterized as secreted factors that are sensitive to MMP inhibitor and have apparent molecular masses of 50 and 25 kDa. This is in sharp contrast to the pro-MMP-9 activator from mouse and human skin, which is a chymotrypsin-like proteinase. Among multiple MMPs induced in HSCs by the dual stimulation, MMP-13 is most conspicuously up-regulated and meets all criteria as the pro-MMP-9 activator. HSC cultured in three-dimensional type-I collagen, but not in Matrigel, IL-1 induces expression of MMP-13 and its matured form at 50 and 25 kDa, respectively. In vitro reconstitution experiment proves that MMP-13, but not its zymogen, activates pro-MMP-9. Further, short hairpin RNA targeting MMP-13 abolishes pro-MMP-9 activation and HSC trans-differentiation. We further demonstrate that pro-MMP-13 activation is facilitated with a membrane-associated factor, inhibited with tissue inhibitor of metalloproteinase-2, and abolished with short hairpin RNA against MMP-14. Moreover, pro-MMP-13 is also activated by a secreted factor, which is absorbed by gelatin-Sepharose and reconstituted with MMP-9. Thus, IL-1-induced trans-differentiation of HSCs in three-dimensional extracellular matrix is facilitated by an MMP activation cascade (MMP-14 > MMP-13 > MMP-9) and a positive feedback loop of MMP-9 > MMP-13, suggesting their critical roles in liver injury and repair.
IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system (2000)

SH-SY5Y human neuroblastoma cells express IGF receptors, IGFs and IGF binding proteins (IGFBPs), and provide a model for studying the role of the IGF system in human neuronal development. We investigated the effect of IGF-I and des(1-3)IGF-I on the motility of SH-SY5Y cells by a cell migration assay based on the assessment of the number of cells which migrated across 8 microm pore size membranes and around an agarose drop. IGF-I and des(1-3)IGF-I stimulated neuroblast chemotaxis in a dose-dependent manner. Treatment of cells with these agents for 24 h resulted in a significant increase (IGF-I by 70% and des(1-3)IGF-I by 90%; P<0. 0001) in cell motility relative to control conditions. Addition of monoclonal antibody against type 1 IGF receptor (alpha-IR3), significantly (P<0.05) reduced the cell motility induced by IGF-I (by 30%) and des(1-3)IGF-I (by 70%). Wortmannin, a specific inhibitor of phosphatidylinositol (PI)-3 kinase intracellular signalling, also reduced the IGF-stimulated cell migration (by over 40%, P<0.01), indicating a key role of the PI-3 kinase pathway in mediating the IGF effect on neuroblast migration. Finally, cell treatment with plasminogen (PLG) markedly enhanced neuroblast migration (by over 200%, P<0.01), whereas incubation with the PLG inhibitor 4-(2-aminoethyl)-benzenesulphonyl fluoride reduced cell motility (by 80%, P<0.01), thus suggesting an involvement of PLG-dependent IGFBP proteolysis in the regulation of neuroblast motility. In conclusion, IGF-I is a potent stimulator of neuroblast migration through the activation of type 1 IGF receptor and the PI-3 kinase intracellular pathway. IGFBPs and the plasmin system seem to play a role in cell motility, although the nature and the extent of their involvement has yet to be elucidated.
Why the United States is Losing the War in Iraq (2005)

Can ragtag guerrilla armies defeat larger, better trained, and better equipped forces? Only if they have popular support, avoid pitched battles, develop an alternative government, and create a widespread sense that they can win. All of these factors came together in Iraq, partly because of misguided U.S. policies.
Performance of dynamic channel assignment techniques in a cellular environment (2003)

Dynamic channel assignment (DCA) techniques have been applied to European cordless telephone systems such as CT2 and DECT, however the technique is yet to be applied practically to cellular systems. The author reports on the performance of several dynamic assignment techniques for cellular applications in terms of capacity and outage making comparisons with more conventional fixed channel assignment techniques. Specific attention is given to sectorized configurations, where there appears to be a particular lack of Published information. The author gives results showing that DCA can increase capacity by up to 5 times that of analogue fixed channel assignments without significant degrading call quality.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Correlating protein function and stability through the analysis of single amino acid substitutions (2009)

Our results confirmed that stability change is somehow related to function change. However, we also show that the knowledge of stability changes in no way suffices to predict functional changes and that many function changing mutations have no effect on stability.
Joint Optimization of Index Freshness and Coverage in Real-Time Search Engines (2011)

Real-time search engines are increasingly indexing web content using data streams, since a number of web sources including news and social media sites are now delivering up-to-date information via streams. Accordingly, it is a crucial challenge for a real-time search engine using data streams to improve index freshness that primarily depends on the latencies involved during fetching and indexing processes. Retrieval latency is a time lag between document publication and fetching while indexing latency is a delay required for a fetched document to be indexed, which is caused by finiteness of indexing capacity. The problem of retrieval latency can be satisfactorily addressed by use of appropriate fetching scheduling or recent real-time content notification protocols. However, as the entire volume of real-time content rapidly grows, the indexing latency becomes a challenging problem. Furthermore, the need for maximizing index coverage makes it more difficult to reduce the indexing latency under the limited indexing capacity. We consider a problem of jointly optimizing the indexing latency as well as indexindexing latency coverage, in which their relative importance can be adjusted, and propose an optimization model based on inventory control theory. Extensive experiments have been conducted to validate the proposed model, and suggest that the proposed approach outperforms the other alternatives.
The Demand for an Agribusiness Curriculum (1990)

Agribusiness, Teaching/Communication/Extension/Profession
Acrylic Copolymers for Radiation-Cured Coatings (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcrylic Copolymers for Radiation-Cured CoatingsJ. D. Nordstrom and J. E. HinschCite this: Ind. Eng. Chem. Prod. Res. Dev. 1970, 9, 2, 155–158Publication Date (Print):June 1, 1970Publication History Published online1 May 2002Published inissue 1 June 1970https://pubs.acs.org/doi/10.1021/i360034a007https://doi.org/10.1021/i360034a007research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Pexlib Programming Manual (1992)

SiO2/TiO2 core/shell beads (T-rex) were designed, fabricated and tested for Raman detection of environmental CO2 under real-working conditions, as those encountered, for example, in solar-to-fuel conversion reactions. The exploitation of light trapping and morphology dependent resonances was crucial for extending the limit of detection of CO2 adsorbed on TiO2 surfaces. T-rex beads allowed for achieving surface enhanced Raman scattering (SERS) without using plasmonic metals showing high-efficiency, fast response and reproducibility in CO2 detection in both air and solvents. The dependence of SERS activity on Mie-type resonances was investigated through a systematic comparison of experimental data and numerical simulations, demonstrating that T-rex beads can be tailored for the detection of gaseous environmental pollutants on the basis of simple, Mie-scattering based calculations. Three-dimensional T-rex colloidal crystals were also successfully tested in precise, in situ, real time detection of CO2 as a function of different temperature-sweep cycles.
High-throughput fabrication of micrometer-sized compound parabolic mirror arrays by using parallel laser direct-write processing (2015)

Micrometer-sized parabolic mirror arrays have significant applications in both light emitting diodes and solar cells. However, low fabrication throughput has been identified as major obstacle for the mirror arrays towards large-scale applications due to the serial nature of the conventional method. Here, the mirror arrays are fabricated by using a parallel laser direct-write processing, which addresses this barrier. In addition, it is demonstrated that the parallel writing is able to fabricate complex arrays besides simple arrays and thus offers wider applications. Optical measurements show that each single mirror confines the full-width at half-maximum value to as small as 17.8 μm at the height of 150 μm whilst providing a transmittance of up to 68.3% at a wavelength of 633 nm in good agreement with the calculation values.
BYPASS: an effective method for the refinement of crystal structures containing disordered solvent regions (1990)

A method is described for the least-squares refinement of the atomic parameters of the ordered part of a crystal structure in the presence of disordered solvent areas. Potential solvent regions are identified automatically. The contribution of the observed contents to the total structure factor is calculated via a discrete Fourier transformation, and incorporated in a further least-squares refinement of the ordered part of the structure. The procedure is iterated a few times to convergence. It is found that this mixed discrete-atom and continuous solvent-area model refinement approach greatly improves the quality of discrete atomic parameters, i.e. the geometry and the e.s.d.'s. An electron count over the solvent region in the final difference electron-density map provides a convenient estimate for the number of solvent molecules present in the unit cell. The application of the method to four structures is described.
Microbes and Microbial Products as Herbicides (1990)

Microbes (plant pathogens) and microbial products (phytotoxins) have been shown to have potential as weed control agents. Growth in the interest in these alternative weed control methods has been brought about by a need for less persistent, more selective, and more environmentally safe herbicides. Broad-spectrum and selective activity are concepts important to the development of a weed control agent. Generally, pathogens are host-specific while phytotoxins have a wider range of activity. Over the past several years, new pathogens and microbial phytotoxins from pathogens and other microorganisms have been discovered which can be added to the arsenal of biological weed control weapons. Pathogens, and in some cases phytotoxins, may be used directly on the target species; alternatively, phytotoxins or compounds from non-pathogenic organisms may provide template chemistries for new synthetic herbicide designs. Pathogens also have potential for use in integrated approaches to weed management programs, where the organisms can tolerate the presence of other agricultural chemicals and where they may interact synergistically with herbicides. Genetic engineering and microbial strain selection to increase pathogen virulence, alter host range, and enhance interactions with other chemical regulators or synergists may promote infectivity and weed control efficacy. This chapter reviews some recent advances in the area of isolation and identification of novel microbial chemistries with phytotoxic properties and presents perspectives on other aspects of the use of microbes and natrually occuring microbial compounds for weed control.
La province de Qaṭṭunân à l'époque de Zimrî-Lîm (2013)

La province de Qaṭṭunân était, à l’époque des archives de Mari, une région pauvre et relativement peu peuplée. L’étude présente un survol des toponymes de cette province. Des hypothèses nouvelles de localisation sont faites en fonction des propositions récentes de retrouver Qirdahat dans la région de Hassake (D. Charpin, BBVO 20, p. 67-68) et Saggarâtum dans la région de Buseira (J.-M. Durand, BBVO 20, p. 50). Les toponymes sont énumérés par ordre géographique, du nord au sud, avec les localisations suivantes : Magrisâ (T. Tnenir ?) ; Ṭâbatum (T. Taban) ; Zilhân (sur la rive droite du Habur en face de T. Taban) ; Tehrân ou Tihrân (T. Hirbet Gamel ou éventuellement Tell Adjadja ?) ; Latihum (qui doit être cherchée sur la rive gauche du Habur dans la région de l’actuelle Rašidiya) ; Bît-Kapân (Tell Fiden ?) ; Râhatum (T. Abu Ha’iṭ). En dehors de la vallée du Habur se trouvait Dûr-ṣâbim qui doit être cherchée dans la steppe, à l’ouest du Habur. Le cas de la « Dêr » parfois surnommée « du Balih » est traité et sa localisation dans la région du Djebel Abd-al-Aziz est proposée.
Effects of Phlorizin on Glucose Kinetics in the Bovine (1974)

Glucose excretion from phlorizin was established in calves given different diets and/or different phlorizin doses; the ability of phlorizin to alter gluconeogenesis then was investigated. In calves fed hay, maximum glucose excretion of up to 313 g/day was caused by about 2 g of phlorizin per day. When calves were given only single doses of phlorizin subcutaneously, there was an increased glucose excretion with each increase in phlorizin up to 2 g with either a hay or a grain diet. At all phlorizin dosages, calves fed a high-grain diet had over two times greater glucose excretion than those fed hay. In three grain-fed calves where phlolSzin caused an average glucose excretion of 360 g/day, the only parameter of glucose kinetics that changed from control calves not given phlorizin was irreversib!e loss, which increased 8.2 g/h. Neither pool size nor total entry rate was affected. Phlorizin did not increase gluconeogenesis in fed ruminants.
Diathermo-trabeculotomy ab externo: indications and long-term results. (1977)

The authors present the results of 2 years' observation of 47 eyes operated with diathermo-trabeculotomy ab externo. This technique, based on a diathermic effect in association with trabeculotomy ab externo, allows an ample opening of Schlemm's canal and of the trabecular meshwork, with normalisation of intraocular pressure and outflow facility, for a period of up to 2 years, in open-angle and congenital glaucoma.