gebhart/patrepeval huggingface dataset:
New immortalized human stromal cell lines enhancing in vitro expansion of cord blood hematopoietic stem cells (2004)

One of the most promising technique for the in vitro expansion of cord blood (CB) hematopoietic stem cells (SCs) seems to be their co-culture with stromal feeder-layers. Hence, we developed and immortalized by retroviral transduction with the temperature-sensitive SV40 large T antigen three new human cell lines, two derived from bone marrow (HM1-SV40 and HM2-SV40) and one from umbilical cord (HCB1-SV40), and investigated the inductive capacity of their conditioned culture media on clonal growth of CB hematopoietic SCs. Immunocytochemistry showed that cell lines were positive to either cytokeratins or stromal markers, as well as to epidermal growth factor (EGF), fibroblast growth factor (FGF) and adrenomedullin. Moreover, cell lines expressed interleukin (IL)-1 beta, IL-6, granulocyte macrophage-colony stimulating factor (GM-CSF), G-CSF and stem cell factor (SCF), and secreted variable amount of IL-1 beta, IL-6 and GM-CSF. Collectively, these findings indicate that cell lines possess the stromal-cell phenotype. The conditioned supernatants of the three cell lines induced similar increases in the clonal growth of both fresh and cryopreserved-thawed CB hematopoietic SCs cultured on semisolid media deprived of growth factors and cytokines. However, the inductive capacity was significantly higher in the case of cryopreserved cells, where the rise in clonal growth reached that induced by the addition to the culture media of IL-3, GM-CSF and SCF. Our findings allow us to conclude that our new human stromal cell lines could be used as feeder-layers for CB hematopoietic SC expansion in vitro.
Disfunção aguda devido a uma trombose da prótese da válvula mitral mecânica (2005)

Um homem de 64 anos recebeu uma prótese mecânica CarboMedics de 31 mm para refluxo mitral grave. Após quatro dias, o paciente apresentou-se com fadiga e dispnéia em repouso. Estudos do Doppler ecocardiografia transtorácica e transesofágica confirmaram uma disfunção na mobilidade do folheto da válvula protética devido à trombose e uma operação de emergência foi feita. O pós-operatório transcorreu sem intercorrências. Este é um caso incomum de disfunção grave devido à trombose de uma prótese mitral mecânica em um paciente tomando anticoagulantes orais e calciparina
AEROSPACE LOOKS FOR LIFT FROM E-COMMERCE (2001)

SUBTITLE: THE INTERNET HAS CREATED A WHOLE NEW LANGUAGE FOR BUSINESS. AIRLINES, AIRPORTS, AIRCRAFT MANUFACTURERS AND SUPPLIERS ARE LEARNING TO SPEAK IT.
Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions (2010)

The above point to significant variability in Hsp90 expression with significant implications upon the effectiveness and limitations of anti-Hsp90 drugs.
Transgenerational inheritance of epigenetic states at the murine <i>Axin</i> <sup> <i>Fu</i> </sup> allele occurs after maternal and paternal transmission (2003)

Phenotypic variation that cannot be explained by genetic or environmental heterogeneity has intrigued geneticists for decades. The molecular basis of this phenomenon, however, is largely a mystery. Axin-fused (Axin(Fu)), first identified in 1937, is a classic example of a mammalian allele displaying extremely variable expression states. Here we demonstrate that the presence or absence of its characteristic phenotype, a kinked tail, correlates with differential DNA methylation at a retrotransposon within Axin(Fu) and identify mutant transcripts arising adjacent to the retrotransposon LTR that are likely to be causative of the phenotype. Furthermore, the epigenetic state at Axin(Fu) can be inherited transgenerationally after both maternal and paternal transmission. This is in contrast to epigenetic inheritance at the murine agouti-viable yellow (A(vy)) allele, which occurs through the female only. Unlike the egg, the sperm contributes very little (if any) cytoplasm to the zygote, and therefore paternal inheritance at Axin(Fu) argues against the possibility that the effects are due to cytoplasmic or metabolic influences. Consistent with the idea of transgenerational inheritance of epigenetic marks, we find that the methylation state of Axin(Fu) in mature sperm reflects the methylation state of the allele in the somatic tissue of the animal, suggesting that it does not undergo epigenetic reprogramming during gametogenesis. Finally, we show that epigenetic inheritance is influenced by strain background. These findings enable us to propose a model for transgenerational epigenetic inheritance in mammals.
農業新聞議題與內容之臉書讀者偏好分析：以上下游新聞市集、農傳媒、食力為例 (2018)

食品安全的問題頻頻發生，許多食品企業皆被揭露出所生產之產品具有危險物質，使得農業議題受到社會大眾關注。為了讓農業新聞媒體更有效地制訂內容策略，本研究目的：（一）探討農業新聞媒體的臉書讀者偏好之農業新聞議題類型；（二）探討農業新聞媒體的臉書讀者所偏好的農業新聞內容之差異；（三）探討農業新聞之讀者人口特性。本研究運用Fanpage Karma 和Python Facebook SDK 獲取上下游新聞市集、農傳媒以及食力之數據資料，其中包括新聞文章連結、新聞內容，以及每篇新聞文章所擁有之讚數、留言數、分享數和粉絲成員之人口特性資料（性別、年齡等）。透過使用單因子變異數分析檢測讀者對新聞議題之偏好，以及運用質性內容分析法對受讀者偏好之新聞內容進行分析。研究結果發現，上下游新聞市集的人物與歷史及吃安心、農傳媒的新農鳴，以及食力的食加工最能獲得消費者認同，及進行留言或分享。上下游新聞市集「人物與歷史」議題之讀者偏好具有激勵性及溫馨故事之新聞內容；而「吃安心」議題之讀者偏好揭露黑心食品及廠商之新聞內容；農傳媒「新農鳴」議題之讀者偏好政策發佈與細節說明之新聞內容；而食力「食加工」議題之讀者偏好食品詳細製作流程及原料介紹之新聞內容。另外，農業新聞的男性讀者多於女性讀者，居住地為北部地區最大宗。本研究之研究結果可供農業新聞媒體進行農業相關議題報導時作為參考，以掌握讀者對議題與內容之偏好並有效地制訂內容策略，提升新聞文章之閱讀人數與流量。
Cell like performance using the remotely controlled cellular transmitter (2003)

A system design description is given of a remote-controlled cellular transmitter (RCCT) capable of an output power of over 100 W ERP (effective radiated power) when used with a high-gain antenna. The RCCT provides for remote monitoring and control, and it provides for translation of the control channel. It effectively replaces the cell site as an option, at a fraction of the cost. Implementation details are given along with a performance specification of the major components, and field trial results are discussed. NYNEX's use of the RCCT to provide coverage to the eastern tip of Long Island has proven to be successful.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Unique aspects of cytoplasmic male sterility and fertility restoration in Brassica napus (1999)

Two male sterile cytoplasms, nap and pol, are found in the oilseed rape species Brassica napus. As with many other forms of cytoplasmic male sterility (CMS), the mtDNA regions implicated in specifying the two forms of male sterility contain novel open reading frames (ORFs). Unlike other CMS-associated ORFs, however, a high level of sequence similarity extends over the entire length of the nap and pol CMS-associated ORFs. Moreover, in other plant species where more than one form of CMS is found, the nuclear genes that restore fertility to various male sterile cytoplasms represent distinct genes that map to different nuclear loci. The restorers for the nap and pol cytoplasms (Rfn and Rfp, respectively), however, represent different alleles or haplotypes of a single nuclear locus. Both alleles specify factors that influence mtRNA processing events, but the specific processing events conditioned by the two alleles are different, suggesting that the factors encoded by these genes recognize distinct RNA structural features. Finally, unlike other nuclear genes that affect mitochondrial gene expression, Rfn is capable of modifying the expression of multiple mtDNA regions, some of which are not associated with CMS. Findings made based on this observation are consistent with the view that new alleles of a restorer locus arise in response to natural selective pressures generated by the appearance of new male sterile cytoplasms.
The genetics of mental retardation (2006)

Genetic abnormalities frequently give rise to a mental retardation phenotype. Recent advances in resolution of comparative genomic hybridization and genomic sequence annotation has identified new syndromes at chromosome 3q29 and 9q34. The finding of a significant number of copy number polymorphisms in the genome in the normal population, means that assigning pathogenicity to deletions and duplications in patients with mental retardation can be difficult but has been identified for duplications of MECP2 and L1CAM. Novel autosomal genes that cause mental retardation have been identified recently including CC2D1A identified by homozygosity mapping. Several new genes and pathways have been identified in the field of X-linked mental retardation but many more still await identification. Analysis of families where only a single male is affected reveals that the chance of this being due to a single X-linked gene abnormality is significantly less than would be expected if the excess of males in the population is entirely due to X-linked disease. Recent identification of novel X-linked mental retardation genes has identified components of the post-synaptic density and multiple zinc finger transcription factors as disease causing suggesting new mechanisms of disease causation. The first therapeutic treatments of animal models of mental retardation have been reported, a Drosophila model of Fragile X syndrome has been treated with lithium or metabotropic glutamate receptor (mGluR) antagonists and a mouse model of NF1 has been treated with the HMG-CoA reductase inhibitor lavastatin, which improves the learning and memory skills in these models.
Extended solubility and spin-glass behavior in a Ag-Gd solid solution prepared by mechanical alloying (1995)

The effects of mechanical alloying on the solubility in a Ag-Gd solid solution have been investigated. The study shows that the solubility of Gd in Ag can be extended to about 5 at. % Gd by mechanical alloying from the equilibrium solubility of less than 0.95 at. % Gd. ${\mathrm{Ag}}_{85}$${\mathrm{Gd}}_{15}$ prepared by mechanical alloying exhibits a spin-glass-type transition at \ensuremath{\sim}5 K. A Curie-Weiss behavior at higher temperatures and x-ray patterns of the material indicate that Gd atoms are either dissolved in the Ag matrix or in the form of small clusters of diameters of a few nanometers.
Robust audio precompensation with probabilistic modeling of transfer function variability (2009)

A new approach to the single-channel loudspeaker equalization problem is presented. A scalar discrete-time mixed-phase precompensation filter is designed to be spatially robust, meaning that equalization performance should be insensitive to listener movements within a predefined spatial region. The problem is posed in a single-input multiple-output (SIMO) feedforward control framework and a polynomial solution is derived, based on a set of room transfer functions (RTFs) measured at a number of control points in the region, and a multipoint mean-square error (MSE) criterion. Spatial robustness is obtained by the introduction of two novel strategies. Firstly, a probabilistic model is used to describe the RTF variability around each control point, and the MSE criterion is averaged with respect to this variability. Secondly, the pre-response errors, normally associated with mixed-phase equalizer design, are alleviated by restricting the compensator to have a certain structure. The proposed method is shown to produce filters with excellent time-and frequency-domain performance.
A sigma-delta modulator with a novel chopper correlated double sampled integrator (2011)

This paper presents a fully differential second-order Sigma-Delta modulator (SDM) based on a chopper correlated double sampled integrator. The Correlated double sampling technique (CDS) and chopper stabilization technique (CHS) are used in the first integrator to eliminate the low frequency noise of the amplifier. The whole circuit implemented in a 0.35 um CMOS technology with 3.3V supply voltage. The simulation results show that the proposed SDM has better performance on eliminating the contamination of the low frequency noise of the amplifier than traditional CDS modulator.
Crew Exploration Vehicle Service Module Ascent Abort Coverage (2007)

The Crew Exploration Vehicle (CEV) is required to maintain continuous abort capability from lift off through destination arrival. This requirement is driven by the desire to provide the capability to safely return the crew to Earth after failure scenarios during the various phases of the mission. This paper addresses abort trajectory design considerations, concept of operations and guidance algorithm prototypes for the portion of the ascent trajectory following nominal jettison of the Launch Abort System (LAS) until safe orbit insertion. Factors such as abort system performance, crew load limits, natural environments, crew recovery, and vehicle element disposal were investigated to determine how to achieve continuous vehicle abort capability.
High-temperature, low threshold current, and uniform operation 1×12 monolithic AlGaInAs/InP strain-compensated multiple quantum well laser array in 1.5 μm (1999)

In this paper, we describe the fabrication of a monolithically integrated 1/spl times/12 array of 1.5-/spl mu/m AlGaInAs/InP strain-compensated multiple-quantum-well (MQW) lasers, which has high reliability and highly uniform characteristics in low threshold current, slope efficiency, and lasing wavelength. Besides, each diode on the array exhibits a high characteristic temperature of 88 K and a low slope-efficiency drop of less than 1 dB between 20-80/spl deg/C and a lasing wavelength of 1510 nm at 20/spl deg/C and 20 mA. Also, the diode on the array has a maximum resonance frequency of above 8 GHz or 3-dB modulation bandwidth of 12 GHz.
Estimating the Relative Free Energy of Different Molecular States with Respect to a Single Reference State (1996)

We have investigated the feasibility of predicting free energy differences between a manifold of molecular states from a single simulation or ensemble representing one reference state. Two formulas that are based on the so-called λ- coupling parameter approach are analyzed and compared: (i) expansion of the free energy F(λ) into a Taylor series around a reference state (λ = 0), and (ii) the so-called free energy perturbation formula. The results obtained by these extrapolation methods are compared to exact (target) values calculated by thermodynamic integration for mutations in two molecular systems: a model dipolar diatomic molecule in water, and a series of para-substituted phenols in water. For moderate charge redistribution (≈0.5 e), both extrapolation methods reproduce the exact free energy differences. For free energy changes due to a change of atom type or size, the Taylor expansion method fails completely, while the perturbation formula yields moderately accurate predictions. Both extrapolation methods fail when a mutation involves the creation or deletion of atoms, due to the poor sampling in the reference state simulation of the configurations that are important in the end states of interest. To overcome this sampling difficulty, a procedure based on the perturbation formula and on biasing the sampling in the reference state is proposed, in which soft-core interaction sites are incorporated into the Hamiltonian of the reference state at positions where atoms are to be created or deleted. For mutations going from p-methylphenol to the other five differently para-substituted phenols, the differences in free energy are correctly predicted using extrapolation based on a single simulation of a biased, non-physical reference state. Since a large number of mutations can be investigated using a recorded trajectory of a single simulation, the proposed method is potentially viable in practical applications such as drug design.
Automatic Learning of Repair Strategies for Web Services (2007)

The process of repairing Web Service failures may be connected to the nature of the fault that caused the error generating the failure. The selection strategy for composed services repair may be drawn from an analysis on temporal behavior of the fault, assessing if fault is transient, intermittent or permanent. The repair process strictly depends on the permanence type of faults, as substitution is applied with permanent faults, while retry is chosen with transient faults and the retry period is to be determined. In this paper we propose a methodology and a tool for learning the repair strategies of Web Services to automatically select repair actions. This methodology is able to incrementally learn its knowledge of repairs, as faults are repaired. Thus, it is at runtime possible to achieve adaptability according to the current fault features and to the history of the previously performed repair actions. This learning technique and the strategy selection are based on a Bayesian classification of faults in permanent, intermittent and transient, followed by a comparative analysis between current fault features and previously classified faults features which suggests which repair strategy has to be applied. Therefore, this methodology includes the ability to learn autonomously both model parameters, which are useful to determine the fault type, and repair strategies which are successful and proper for a particular fault.
TNF-α Sensitizes Normal and Fibrotic Human Lung Fibroblasts to Fas-Induced Apoptosis (2005)

Pulmonary accumulation of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis/usual interstitial pneumonia (IFP/UIP) has been linked to (1) increased migration of a circulating pool of fibrocytes, (2) cell proliferation, and (3) resistance to apoptosis. The mechanism of physiologic apoptosis of lung fibroblasts is poorly understood. Using normal and fibrotic human lung fibroblasts and the human lung fibroblast cell line, MRC-5, we examined the regulation of Fas-induced apoptosis by the proinflammatory cytokines TNF-alpha and IFN-gamma. Herein, we show that the basal resistance of lung fibroblasts and myofibroblasts to Fas-induced apoptosis is overcome by sensitization with TNF-alpha. IFN-gamma did not sensitize cells to Fas-induced apoptosis, but exhibited synergistic activity with TNF-alpha. Sensitization by TNF-alpha was observed in MRC-5 cells and in fibroblasts and myofibroblasts from normal and fibrotic human lung, suggesting that this represents a conserved mechanism to engage Fas-induced apoptosis. The mechanism of sensitization was localized at the level of recruitment of the adapter protein, FADD, to the cytoplasmic domain of Fas. Collectively, these findings suggest that fibroblast apoptosis involves two steps, sensitization and induction, and that inadequate pulmonary inflammation in IPF/UIP may favor fibroblast accumulation by reducing sensitization to apoptosis.
Novel Covert Data Channel in Wireless Sensor Networks Using Compressive Sensing (2012)

Wireless sensor networks (WSN) is a novel data centered self-organizing network that can be used in acquiring and processing information. With the limited energy of sensor nodes and the increasing requirement of secure data transmission, how to save nodes energy as well as realize a transmission of sensitive information in WSN effectively is becoming an interesting research problem recently. In this paper, we present a novel scheme to transmit sensitive information in the pattern of energy efficient way by utilizing compressive sensing (CS) which is an emerging technology in recent years. In this method, sensor nodes need not to do complex computing but simple linear operations which can save the energy extensively, and thus extend the life time of the wireless sensor networks. Theory analysis and detail simulation results demonstrate the effective of our method, and the sensitive information can be accurately reconstructed even when the communication channel is lossy.
Implementing a scalable ASC processor (2003)

Previous papers (Walker et al. (2001); Wu et al. (2002)) have described our implementation of a small prototype processor and control unit for associative computing, called the ASC processor. That initial prototype was implemented on an Altera education board using an Altera FLEX 10K FPGA, and was limited to an unrealistic 4 processing elements (PE). This paper describes a more complete implementation - a scalable ASC processor that can scale up to 52 PE on an Altera APEX 20KE board, or further on larger FPGA. This paper also proposes extensions to support multiple control units and control parallelism.
High-Speed Surface Flaw Inspection (1976)

An optical surface flaw inspection monitor has been developed as a part of Frankford Arsenal's Cartridge Case Measurement Eject System for 5.56 mm small-caliber ammunition. This surface flaw monitor uses scattered light electro-optical instrumentation to detect flaw presence on 100% of the cartridge case surface at case throughput rates exceeding 1200 cases/minute. A line source formed from a laser source with cylindrical optics automatically tracks a spinning cartridge on the perimeter of a wheel-type mechanical handling system. Individual fiber optic elements located at each case position direct scattered light from surface zones of the case to common photomultiplier-based optical detectors. The detected signals are corrected for illumination and receiving optics transmissions and then frequency-processed. The frequency pattern of the detected scattered light relates directly to the type of surface flaw, such as dents and scratches. Go/no-go signals are fed directly to a minicomputer for implementation of a reject function on the mechanical handling hardware.
How to upgrade CATV networks to provide interactive ATM-based services (2002)

The paper reports on work carried out within the RACE project R2121-BISIA (broadband interactive services on integrated access). It first introduces a common ATM based platform for supporting emerging interactive audio-visual services on different access types. It then describes how it is applied to CATV networks and provides details on its architecture and the key technologies enabling the introduction of ATM in CATV networks. Finally the paper describes the BISIA field trial taking place in the fall of 1995.
The Right to Touch and Be Touched (1996)

Touching is an integral part of human behaviour; from the moment of birth until they die, people need to be touched and to touch others. Touching is an intimate action that implies an invasion of the individual's personal, private space. In ethical terms, the question of touching is closely related to the patient's right to integrity and inviolability. The purpose of this study was to describe touching as it is experienced by elderly patients and nurses in long-term care. Touching was approached as a form of communication and as an important part of nursing practice. The participants, 25 patients and 30 nurses, were interviewed using a semistructured schedule. The data were analysed using the method of content analysis. The patients experienced touching by nurses as gentle, comforting and important. The nurses, for their part, experienced touching by patients as easy and natural. The patients rarely touched nurses more than was necessary. In some cases, nurses had to cope with violent touching by patients. Some women nurses interpreted touches by male patients as having a sexual nature and as annoying. This had taught male patients to avoid touching nurses. On the other hand, friendly and grateful touches by patients were very important to nurses. When used for emotional purposes only, touching presupposed a good relationship between nurses and their patients. Although touching is extremely common in nursing practice, there has been very little research into its meaning. More work is therefore needed to explore the role and meaning of touching in nursing.