gebhart/patrepeval huggingface dataset:
AIDS-related airway disease. (1997)

To our knowledge, the importance of airway disease in HIV-positive patients has been infrequently noted. This deficit likely reflects a combination of factors including lack of familiarity with recent changes in clinical and epidemiologic patterns of pulmonary manifestations of HIV infection and documented limitations of chest radiography for identifying and differentiating airway disease from other causes of pulmonary disease in HIV-positive patients. Familiarity with the imaging findings for these various entities should facilitate prompt diagnosis and treatment. The accuracy of CT in detecting airway disease [55-59] is well established and should be of value in excluding more common diseases that may be initially confused with airway abnormalities [60, 61]. Small airways disease, in particular, which may be occult or mimic an interstitial infiltrate on chest radiography, can be recognized with CT as likely representing infectious bronchitis or bronchiolitis. Patients with findings suggesting bacterial infections may benefit from empiric antibiotic therapy. CT also may be valuable for differentiating between various noninfectious pulmonary diseases, allowing a presumptive diagnosis of parenchymal Kaposi's sarcoma in the appropriate clinical context. In distinction, by detecting localized endobronchial or parenchymal abnormalities in patients with mycobacterial or fungal infections or lymphoma, CT may be valuable for deciding between various invasive methods of obtaining either histologic or bacteriologic diagnoses.
Grape-derived polyphenols improve aging-related endothelia dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system (2012)

International audience
Carbamazepine versus Sulthiame in Treating Benign Childhood Epilepsy With Centrotemporal Spikes (2002)

We compared the therapeutic efficacy of carbamazepine versus sulthiame in patients with benign childhood epilepsy with centrotemporal spikes. Drug efficacy was evaluated only in those patients who initiated treatment with any drug after at least three seizures. Thirty-eight patients who received carbamazepine and 18 patients who received sulthiame were included in the analysis. Cessation of seizures was observed in 73.6% of the former and in 66.7% of the latter (P = not significant). Five of eight patients who were switched to sulthiame after failing carbamazepine became seizure free, whereas none of the three patients who failed sulthiame became seizure free after being switched to carbamazepine. The rate of drug discontinuation owing to adverse reaction was 15% in carbamazepine and 14.3% in sulthiame. Normalization of interictal epileptiform activity on electroencephalography was seen more often following treatment with sulthiame (71%) than with carbamazepine (42%) (P = not significant). No significant differences between these two medications were found in the treatment of benign childhood epilepsy with centrotemporal spikes in this small patient sample.
The Impact of E‐Mobility in a Future Energy System Dominated by Renewable Electricity (2017)

Abstract Battery and fuel cell electric cars have been identified as solution to meet the target of reducing greenhouse gas emissions by 80 to 95 % before 2050, however they will also impact the increasingly renewable electricity‐based energy system. A numerical case study is conducted for a prototypical station consisting of hydrogen refueling equipment for fuel cell electric vehicles and charging points for battery electric vehicles located in Northern Germany with rather good wind but limited photovoltaics conditions. Major conclusions for the impact of both e‐mobility concepts on the energy system are drawn.
Review : Glial Boundaries and Scars: Programs for Normal Development and Wound Healing in the Brain (1995)

Early studies of glial boundaries, which are composed of immature astrocytes and extracellular matrix mol ecules (which they express), initially offered insight into the partitioning that occurs in the developing nervous system. More recently, however, it has been suggested that similar "boundaries" may have important roles in other processes occurring in the brain, including repair after traumatic brain injury. As more is understood about the expression and function of boundary molecules and glia, their potential importance is becoming apparent in numerous neuropathological conditions, including neurodegeneration and neuroregeneration in Alzheimer's and Huntington's diseases as well as in brain neoplasms. Furthermore, before we can hope to fully understand and facilitate regeneration in the compromised brain, our knowledge of the glial boundary, both during development and in the adult, must be more complete. The Neuroscientist 1:142-154, 1995
Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinus (2003)

Stereotactic radiosurgery (SRS) is performed with increasing frequency in the treatment of residual or recurrent pituitary adenomas. Its major associated risk in these cases of residual or recurrent pituitary tumor adjacent to normal functional pituitary gland is radiation exposure to the pituitary, which frequently leads to the development of hypopituitarism. The authors describe a technique of pituitary transposition to reduce the radiation dose to the normal pituitary gland in cases of planned radiosurgical treatment of residual pituitary adenoma within the cavernous sinus. A sellar exploration for tumor resection is performed, the pituitary gland is transposed from the region of the cavernous sinus, and a fat and fascia graft is interposed between the normal pituitary gland and the residual tumor in the cavernous sinus. The residual tumor may then be treated with SRS. The increased distance between the normal pituitary gland and the residual tumor facilitates treatment of the tumor with radiosurgery and reduces radiation exposure to the normal pituitary gland.
ChemInform Abstract: STUDIES ON OXYCHLORINATION CATALYSTS OF 1,3‐BUTADIENE PART 2, CARRIER EFFECTS ON SUPPORTED CUCL2‐H3PO4‐LICL CATALYSTS FOR OXYCHLORINATION OF 1,3‐BUTADIEN (1975)

Abstract Die zu den Dichlorbutenen (II) und (III) führende Oxychlorier‐ung von 1,3‐Butadien (I) in Gegenwart von Phosphorsäure, Lithiumchlorid und auf verschiedenen Trägern (Aktivkohle, Silicagel, γ‐Aluminiumoxid, Celite, Siliciumcarbid, gesintertem Aluminiumoxid/Siliciumdioxid) niedergeschlagenem Kupfer(II)‐chlorid wurde in Abhängigkeit vom Träger und der Temperatur (130‐2750) untersucht.
Fatty Acid Synthetase from Lactating Rat Mammary Gland (1971)

Abstract Homogeneous preparations of fatty acid synthetase from mammary glands of lactating rats were used to prepare an antiserum and a γ-globulin fraction was isolated from the antiserum. The antiserum and the γ-globulin fraction were shown to be specific against the fatty acid synthetase multienzyme complex. Addition of the γ-globulin to homogenate fractions of lactating rat mammary glands, resulted in complete inhibition of synthesis, from acetate, of fatty acids of all chain lengths. These results show that the multienzyme complex is an obligatory enzyme for the synthesis of all chain length fatty acids in the mammary glands of lactating rats. The fatty acid synthetase from mammary gland produces almost exclusively palmitic acid from malonyl-CoA when acyl-CoA derivatives of chain length C2 to C8 were used as starters. Butyryl-CoA was found to be the most efficient starter, having the highest Vmax and the lowest Km of all acyl-CoA derivatives tested. The specificity of the thioesterase activity associated with the synthetase was also studied with acyl-CoA derivatives as model substrates. Activity was maximal for palmityl and stearyl thioesters, but some activity was indicated with thioesters of chain length C2 to C8. The chain length specificity of thioesterase activity was quite similar to that reported for the pigeon liver enzyme, despite the fact that the liver and mammary gland synthetases produce different chain length fatty acids in homogenate or tissue slice preparations, and presumably, therefore, in vivo. The results are discussed in relation to possible mechanisms for termination of growth of the carbon chain in fatty acid synthesis.
Milk Irradiation, Irradiation Preservation of Milk and Milk Products (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMilk Irradiation, Irradiation Preservation of Milk and Milk ProductsJ. H. Wertheim, R. N. Roychoudhury, Johan Hoff, S. A. Goldblith, and B. E. ProctorCite this: J. Agric. Food Chem. 1957, 5, 12, 944–950Publication Date (Print):December 1, 1957Publication History Published online1 May 2002Published inissue 1 December 1957https://pubs.acs.org/doi/10.1021/jf60082a009https://doi.org/10.1021/jf60082a009research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Applying Popular Usability Heuristics to Gesture Interaction in the Vehicle (2014)

Recent technological advances have led to the ability to reliably track the human body at low cost, allowing for the proliferation of Air Gesture (AG) interfaces. It has been proposed that AGs may be a safe and effective way to interact with in-vehicle technologies. However, designers do not presently have a well developed/adapted set of heuristics, which they can consult to ensure their designs are suitable for the driving environment. This paper aims to address this by discussing how a popular set of human-computer interaction heuristics can be applied to AGs in the vehicle.
High-performance direct digital frequency synthesizers in 0.25 /spl mu/m CMOS using dual-slope approximation (2005)

This paper presents a detailed description of direct digital frequency synthesizers (DDFS) using an optimized piecewise linear approximation for phase to sine mapping, named dual-slope. The dual-slope technique allows reducing ROM size with respect to previously proposed piecewise-linear approximation approaches, with beneficial effects on system performances. Two high-speed DDFS have been fabricated and characterized in 0.25 /spl mu/m CMOS technology. Both circuits produce two quadrature 12 bit outputs with a spectral purity of 80 dBc. The first circuit reaches a maximum operating frequency of 600 MHz by using six pipelining stages. The second circuit operates up to 480 MHz clock speed while dissipating only 72 /spl mu/W/MHz. Analytical investigation of spectral performances achievable by using dual-slope approximation and detailed description of high-speed flip-flop employed in 600 MHz DDFS are also presented in this paper.
Attuatori intelligenti per macchine agricole (2012)

Lo sviluppo di sistemi meccatronici applicati ai veicoli e la necessità di migliorare gli aspetti energetici anche nelle macchine agricole ha portato allo studio e allo sviluppo di tecnologie alternative rispetto alle soluzioni idrauliche tradizionali
Silver (I) cation specifically stabilizes heteroduplex with C:C mismatch base pair: toward the efficient detection of single nucleotide polymorphism (2) (2004)

We examined the effect of silver (I) cation on the thermal stability of heteroduplex and homoduplex. Addition of silver (I) cation increased the melting temperature of heteroduplex containing C:C mismatch base pair by about 3-4 degrees C. The thermal stability of homoduplex and heteroduplexes containing other kinds of mismatch base pairs was not significantly changed by the addition of silver (I) cation. We conclude that silver (I) cation specifically stabilizes heteroduplex containing C:C mismatch base pair. Our results certainly support the idea that the addition of silver (I) cation to C:C mismatch base pair in heteroduplex could be a convenient strategy for heteroduplex analysis and may eventually lead to progress in single nucleotide polymorphism genotyping.
Asymmetric tin–vanadium redox electrolyte for hybrid energy storage with nanoporous carbon electrodes (2017)

Redox active electrolytes in combination with nanoporous carbon electrodes combine high power with high energy storage performance metrics.
Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. (1999)

DNA-dependent protein kinase (DNA-PK) controls signal transduction following DNA damage. However, the molecular mechanism of the signal transduction has been elusive. A number of candidates for substrates of DNA-PK have been reported on the basis of the in vitro assay system. In particular, the Ser-15 amino acid residue in p53 was one of the first such in vitro substrates to be described, and it has drawn considerable attention due to its biological significance. Moreover, p53 Ser-15 is a site that has been shown to be phosphorylated in response to DNA damage. In addition, crucial evidence indicating that DNA-PK controls the transactivation of p53 following DNA damage was reported quite recently. To clarify these important issues, we conducted the experiments with dna-pkcs null mutant cells, including gene knockout cells. As a result, we detected enhanced phosphorylation of p53 Ser-18, which corresponds to Ser-15 of human p53, and significant expression of p21 and mdm2 following ionizing radiation. Furthermore, we identified a missense point mutation in the p53 DNA-binding motif region in SCGR11 cells, which were established from severe combined immunodeficient (SCID) mice and used for previous study on the role of DNA-PK in p53 transactivation. Our observation clearly indicates that DNA-PK catalytic subunit does not phosphorylate p53 Ser-18 in vivo or control the transactivation of p53 in response to DNA damage, and these results further emphasize the different pathways in which ataxia telangiectasia-mutated (ATM) and DNA-PK operate following radiation damage.
LAN: Token Ring (1997)

Token ring networks were developed by several manufacturers, the most prevalent being the IBM Token Ring. Token ring networks cope well with high network traffic loadings. They were at one time extremely popular but their popularity has since been overtaken by Ethernet. Token ring networks have, in the past, suffered from network management problems and poor network fault tolerance.
Induction of alkaline phosphatase in choriocarcinoma cells by 1‐β‐D‐arabinofuranosyl‐cytosine, mitomycin C, phleomycin, and cyclic nucleotides (1977)

Abstract Alkaline phosphatase is induced in cultured human choriocarcinoma cells by three inhibitors of DNA synthesis which alter DNA structure: 1‐β‐D‐arabinofuranosyl‐cytosine, mitomycin C, and phleomycin. No induction is observed with the inhibitors, hydroxyurea and thymidine, which do not alter DNA structure. Cyclic AMP, analogs of cyclic nucleotides, and sodium butyrate also induce alkaline phosphatase in these cells. Among the cyclic nucleotides tested, dibutyryl cyclic AMP is the best inducer, whereas dibutyryl cyclic GMP is a poor inducer. Induction of alkaline phosphatase by inhibitors of DNA synthesis or by exposure to dibutyryl cyclic AMP appears to utilize different mechanisms. Maximum induction is observed after simultaneous addition of both types of inducers at the concentrations found to be optimal for each inducer alone. Under these conditions, the induced activity is equal to or greater than the sum of the activities induced by each inducer. RNA synthesis and protein synthesis are required for induction. Dibutyryl cyclic AMP added to cultures of choriocarcinoma cells is not degraded in the culture medium, but is extensively degraded in the cells. Nevertheless, significant amounts of dibutyryl and monobutyryl cyclic AMP are found intracellularly throughout the experiment. Since the cellular uptake of dibutyryl cyclic AMP is extremely slow, the amount of butyrate released by intracellular degradation cannot account for the observed induction. Neither the rate of uptake nor the stability of dibutyryl cyclic AMP are changed by the addition of 1‐β‐D‐arabinofuranosyl‐cytosine to the culture medium. Furthermore, 1‐β‐D‐arabinofuranosyl‐cytosine inhibits the induction by sodium butyrate. The results indicate that butyrate is not the major mediator of induction by dibutyryl cyclic AMP.
<title>Lifetime survivability of contaminated target-chamber optics</title> (1997)

Target chambers used for inertial confinement fusion expose laser optics to a very hostile environment not only from high-fluence laser irradiation but also x-ray irradiation and particulate debris from targets and chamber wall materials. Expendable debris shields provide the first line of defense to more costly optics upstream in the laser beam path to contaminants generated within the target chamber. However, the replacement of a large number of debris shields is also an expensive proposition so that extending their usable lifetime within the chamber is of crucial importance. We have conducted tests to show that optics can both be cleaned and damaged by laser irradiation at 355 nm after being contaminated with potential chamber-wall materials such as B<SUB>4</SUB>C and Al<SUB>2</SUB>O<SUB>3</SUB>. Such optics can survive from one to hundreds of laser shots depending on the degree of contamination and laser fluence levels. Similarly, we have studied the survivability of optics that have been exposed to direct contamination from representative target materials irradiated in the target chamber. We have also studied the effects on optics that were not directly exposed to targets yet received secondary exposure form the above directly-exposed samples.
Analysis of magnetic hysteresis in a high-precision e-core reluctance actuator compared to measurements (2012)

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes acute and chronic infections in immunocompromised individuals. It is also a model organism for bacterial biofilm formation. Acute infections are often associated with planktonic or free-floating cells, high virulence and fast growth. Conversely, chronic infections are often associated with the biofilm mode of growth, low virulence and slow growth that resembles that of planktonic cells in stationary phase. Biofilm formation and type III secretion have been shown to be reciprocally regulated, and it has been suggested that factors related to acute infection may be incompatible with biofilm formation. In a previous proteomic study of the interrelationships between planktonic cells, colonies and continuously grown biofilms, we showed that biofilms under the growth conditions applied are more similar to planktonic cells in exponential phase than to those in stationary phase. In the current study, we investigated how these conditions influence the production of virulence factors using a transcriptomic approach. Our results show that biofilms express the type III secretion system, whereas planktonic cells do not. This was confirmed by the detection of PcrV in the cellular and secreted fractions of biofilms, but not in those of planktonic cells. We also detected the type III effector proteins ExoS and ExoT in the biofilm effluent, but not in the supernatants of planktonic cells. Biofilm formation and type III secretion are therefore not mutually exclusive in P. aeruginosa, and biofilms could play a more active role in virulence than previously thought.
Parsing local signal evolution directly from a single‐shot MRI signal: A new approach for fMRI (2003)

In this work a new single-shot MRI method, single-shot parameter assessment by retrieval from signal encoding (SS-PARSE), is introduced. This method abandons a fundamental simplifying assumption that is used in conventional MRI methods. Established MRI methods implicitly assume that the local intrinsic signal does not change its amplitude or phase during signal acquisition, even though these changes may be substantial, especially during the relatively long signals used in single-shot image acquisitions. SS-PARSE, on the other hand, acknowledges local decay and phase evolution, and models each signal datum as a sample from (k,t)-space rather than k-space. Because of this more accurate signal model, SS-PARSE promises improved performance in terms of accuracy and robustness, but requires more intensive reconstruction computations. The theoretical properties of the method are discussed, and simulation results are presented that demonstrate more robust and accurate measurements of relaxation rate changes associated with brain activation in functional MRI (fMRI), freedom from geometric errors due to off-resonance frequencies, and better tolerance of the large susceptibility gradients that occur naturally in parts of the brain. In addition, this technique has the potential to assess nonexponential relaxation behavior during a single-shot signal.
ChemInform Abstract: A Facile Synthesis of (2R,3S)‐1‐Amino‐3‐tert‐butoxycarbonylamino‐2‐hydroxy‐4‐phenylbutane: A Useful Component Block of HIV Protease Inhibitor. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Distributed Signature Detection Method for Detecting Intrusions in Sensor Systems (2013)

Sensor nodes in wireless sensor networks are easily exposed to open and unprotected regions. A security solution is strongly recommended to prevent networks against malicious attacks. Although many intrusion detection systems have been developed, most systems are difficult to implement for the sensor nodes owing to limited computation resources. To address this problem, we develop a novel distributed network intrusion detection system based on the Wu-Manber algorithm. In the proposed system, the algorithm is divided into two steps; the first step is dedicated to a sensor node, and the second step is assigned to a base station. In addition, the first step is modified to achieve efficient performance under limited computation resources. We conduct evaluations with random string sets and actual intrusion signatures to show the performance improvement of the proposed method. The proposed method achieves a speedup factor of 25.96 and reduces 43.94% of packet transmissions to the base station compared with the previously proposed method. The system achieves efficient utilization of the sensor nodes and provides a structural basis of cooperative systems among the sensors.