gebhart/patrepeval huggingface dataset:
Increased response to morphine in mice lacking protein kinase C epsilon (2020)

The protein kinase C (PKC) family of serine–threonine kinases has been implicated in behavioral responses to opiates, but little is known about the individual PKC isozymes involved. Here, we show that mice lacking PKCε have increased sensitivity to the rewarding effects of morphine, revealed as the expression of place preference and intravenous self-administration at very low doses of morphine that do not evoke place preference or self-administration in wild-type mice. The PKCε null mice also show prolonged maintenance of morphine place preference in response to repeated testing when compared with wild-type mice. The supraspinal analgesic effects of morphine are enhanced in PKCε null mice, and the development of tolerance to the spinal analgesic effects of morphine is delayed. The density of μ-opioid receptors and their coupling to G-proteins are normal. These studies identify PKCε as a key regulator of opiate sensitivity in mice.
MENTAL SKILL SEBAGAI CHARACTER BUILDING WASIT TENIS LAPANGAN (2021)

Tujuan penelitian ini adalah untuk mengetahui keterampilan mental wasit tenis lapangan. Penelitian ini dilakukan terhadap wasit tenis yang bertugas pada asian games 2018 dan asian paragames 2018, alat penilaian berupa quesioner dan wawancara yang menilai 3 aspek utama yaitu Fundamental skills, Psychosomatic skills, dan Cognitive skills, yang diberikan kepada 55 sempel wasit dari berbagai daerah di Indonesia. Hasil penelitian diketahui bahwa wasit memiliki kemampuan yang sangat baik dan menggunakan kemampuan mental secara signifikan, wasit memiliki aspek yang sangat baik dalam hal penetapan tujuan, kepercayaan diri, keterlibatan, mengendalikan rasa takut, konsentrasi, kontrol gangguan, imagery dan perencanaan kompetensi namun masih rendah dalam hal aktivasi, relaksasi, reaksi terhadap stres, dan praktik mental. Dalam meningkatkan kualitas mental skill seorang wasit diperlukan adanya pelatihan yang harus dibuat agenda tahunan dalam menciptakan wasit yang lebih baik lagi.
Neuropeptide Y Induced Feeding in the Rat Is Mediated by a Novel Receptor (1997)

There are now six recognized neuropeptide Y (NPY) receptor subtypes (Y1–Y4 and two recently cloned distinct receptors labeled Y5), of which Y1 and one of the Y5’s have been suggested could mediate the effect of NPY on feeding. The fragments NPY(2–36) and NPY(3–36), which bind Y1 only poorly, were injected intracerebroventricularly (icv) and found to have similar dose-response relationships to NPY in the stimulation of feeding. However NPY(13–36), which stimulates both Y2 and Y5, caused no increase in food intake, even at high doses. Maximal stimulation with the classical Y1 agonist[ Pro34]-NPY produced only 50% of the maximum effect of NPY itself despite fully inhibiting adenylyl cyclase activity in vitro in a Y1 system. The novel fragment[ Pro34]-NPY(3–36) is as effective at stimulating food intake as the classical Y1 analogue [Pro34]-NPY but bound to the Y1 receptor with only 1/20th of the affinity of NPY and failed to inhibit adenylyl cyclase through this receptor.[ Pro34]-NPY(3–36) is therefore a relatively appetite-selective ligand. Coadministration of high dose NPY(13–36) and [Pro34]NPY did not enhance feeding compared with[ Pro34]-NPY alone. In addition, the NPY Y1 receptor antagonist BIBP-3226, which does not bind Y2, Y4, or Y5 receptors, significantly reduced NPY induced feeding. These results indicate that the feeding effect of icv NPY involves a novel receptor and that it is functionally distinct from the recognized receptor subtypes.
Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling Pathways (2020)

Directed differentiation of human pluripotent stem cells varies in specificity and efficiency. Stochastic, genetic, intracellular, and environmental factors affect maintenance of pluripotency and differentiation into early embryonic lineages. However, factors affecting variation in in vitro differentiation to defined cell types are not well understood. To address this, we focused on a well-established differentiation process to cerebral cortex neural progenitor cells and their neuronal progeny from human pluripotent stem cells. Analysis of 162 differentiation outcomes of 61 stem cell lines derived from 37 individuals showed that most variation occurs along gene expression axes reflecting dorsoventral and rostrocaudal spatial expression during in vivo brain development. Line-independent and line-dependent variations occur, with the latter driven largely by differences in endogenous Wnt signaling activity. Tuning Wnt signaling during a specific phase early in the differentiation process reduces variability, demonstrating that cell-line/genome-specific differentiation outcome biases can be corrected by controlling extracellular signaling.
Measurement and Prediction of Electrical Contact Resistance Between Gas Diffusion Layers and Bipolar Plate for Applications to PEM Fuel Cells (2004)

The electrical contact resistance between gas diffusion layers and bipolar flow channel plates is one of the important factors contributing to the operational voltage loss in polymer electrolyte membrane (PEM) fuel cells. Effective analysis and design of fuel cells therefore need to account for the contact resistance in deriving the polarization curve for the cell. Despite its significance, relatively scant work is reported in the open literature on the measurement and modeling of the contact resistance in fuel cell systems, and the present work aims to fill this void. Experimental data are reported for the first time to show the effects of different gas diffusion layer materials and contact pressure on the electrical contact resistance. A fractal asperity based model is adopted to predict the contact resistance as a function of pressure, material properties, and surface geometry. Good agreement is observed between the data and the model predictions for a wide range of contacting pressures and materials.
Rehabilitation of executive functioning: An experimental–clinical validation of Goal Management Training (2000)

Two studies assessed the effects of a training procedure (Goal Management Training, GMT), derived from Duncan's theory of goal neglect, on disorganized behavior following TBI. In Study 1, patients with traumatic brain injury (TBI) were randomly assigned to brief trials of GMT or motor skills training. GMT, but not motor skills training, was associated with significant gains on everyday paper-and-pencil tasks designed to mimic tasks that are problematic for patients with goal neglect. In Study 2, GMT was applied in a postencephalitic patient seeking to improve her meal-preparation abilities. Both naturalistic observation and self-report measures revealed improved meal preparation performance following GMT. These studies provide both experimental and clinical support for the efficacy of GMT toward the treatment of executive functioning deficits that compromise independence in patients with brain damage.
Intramolecular excimers based on rigidly-linked platinum(ii) complexes: intense deep-red triplet luminescence in solution (2008)

By linking together two cyclometallated, N--C--N-coordinated platinum(II) complexes through a xanthene core, intense luminescence in the red region of the spectrum is achieved in solution at room temperature (lamda max = 690 nm, phi(lum) = 0.20, tau = 1.7 micros in CH2Cl2) due to the efficient formation of an intramolecular excimer.
Gastro-oesophageal reflux treatment for asthma in adults and children (2003)

In asthmatic subjects with gastro-oesophageal reflux, (but who were not recruited specifically on the basis of reflux-associated respiratory symptoms), there was no overall improvement in asthma following treatment for gastro-oesophageal reflux. Subgroups of patients may gain benefit, but it appears difficult to predict responders.
Are the Ro RNP‐associated Y RNAs concealing microRNAs? Y RNA‐derived miRNAs may be involved in autoimmunity (2011)

Here we discuss the hypothesis that the RNA components of the Ro ribonucleoproteins (RNPs), the Y RNAs, can be processed into microRNAs (miRNAs). Although Ro RNPs, whose main protein components Ro60 and La are targeted by the immune system in several autoimmune diseases, were discovered many years ago, their function is still poorly understood. Indeed, recent data show that miRNA-sized small RNAs can be generated from Y RNAs. This hypothesis leads also to a model in which Ro60 acts as a modulator in the Y RNA-derived miRNA biogenesis pathway. The implications of these Y RNA-derived miRNAs, which may be specifically produced under pathological circumstances such as in autoimmunity or during viral infections, for the enigmatic function of Ro RNPs are discussed.
A Low-Power Gigabit CMOS Limiting Amplifier Using Negative Impedance Compensation and Its Application (2011)

This paper presents a low-power, gigabit limiting amplifier (LA) for application to optical receivers that employ the negative impedance compensation technique not only to enhance the gain and bandwidth characteristics simultaneously, but also to allow low-voltage, low-power operations. Test chips of the LA were implemented in a standard 0.18-μ m CMOS process, demonstrating 2.5-Gb/s operation with 40-dB gain, 0.053-UI rms jitter for 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> -1 pseudorandom bit sequence inputs, 9.5-mV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> input sensitivity for 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> bit error rate (BER), and 5.2-mW power dissipation from a single 1.2-V supply. The chip core occupies the area of only 0.25 × 0.1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The proposed LA was adopted to realize a low-power, gigabit optical receiver. Fabricated using the same 0.18-μm CMOS technology, the measured results of the optical receiver chip reveal 132.6-dB Ω transimpedance gain, 2.7-GHz bandwidth even with a large 1.5-pF input parasitic capacitance, -16-dBm optical sensitivity for 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> BER, and 51-mW power dissipation from a single 1.8-V supply. The area of the whole chip is 1.75 × 0.45 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Registration of sliding objects using direction dependent B-splines decomposition (2013)

Sliding motion is a challenge for deformable image registration because it leads to discontinuities in the sought deformation. In this paper, we present a method to handle sliding motion using multiple B-spline transforms. The proposed method decomposes the sought deformation into sliding regions to allow discontinuities at their interfaces, but prevents unrealistic solutions by forcing those interfaces to match. The method was evaluated on 16 lung cancer patients against a single B-spline transform approach and a multi B-spline transforms approach without the sliding constraint at the interface. The target registration error (TRE) was significantly lower with the proposed method (TRE = 1.5 mm) than with the single B-spline approach (TRE = 3.7 mm) and was comparable to the multi B-spline approach without the sliding constraint (TRE = 1.4 mm). The proposed method was also more accurate along region interfaces, with 37% less gaps and overlaps when compared to the multi B-spline transforms without the sliding constraint.
Treatment of Atopic Dermatitis with Dupilumab in a Renal Transplant Patient (2020)

Overview | The leading peer-reviewed scientific journal in contact dermatitis, and the only journal in its field that publishes leading research in atopic, contact, occupational, environmental, and drug dermatitis.
Past, present, and future of coloproctology (1986)

1Sao Paulo, Brazil aPresident of the ISUCRS Read at the XIth Biennial Congress of the International Society of University Colon and Rectal Surgeons, Dallas, Texas, May 4 to 8, 1986.
Correction of Nasal Valve Stenosis With Lateral Suture Suspension (2001)

Relief of nasal valve stenosis can be achieved with suspension suture technique as described. It is effective and, in our experience, has been the most predictable means of achieving improvement in nasal obstruction secondary to nasal valve stenosis.
Different denoising techniques for Medical images in wavelet domain (2013)

Diagnosis of Medical images is very difficult when images are corrupted with noises during the process of acquisition. Now a days development of effective algorithms for removal of noise has become an important research area. Developing Image denoising algorithm is a difficult task since fine details in a medical image embedded with diagnostic information should not be destroyed during noise removal. Most of the existing denoising algorithms use DWT but it has the drawback of shift variance. To overcome this, here the denoising method which uses Undecimated Wavelet Transform to decompose the image has been proposed and the shrinkage operation such as semi-soft and garrote thresholding operators along with traditional hard and soft thresholding operators are used. The suitability of different wavelets for the de-noising of medical images using performance indices SSIM, PSNR and MSE are tested.
Intelligent crawling of web applications for web archiving (2012)

The steady growth of the World Wide Web raises challenges regarding the preservation of meaningful Web data. Tools used currently by Web archivists blindly crawl and store Web pages found while crawling, disregarding the kind of Web site currently accessed (which leads to suboptimal crawling strategies) and whatever structured content is contained in Web pages (which results in page-level archives whose content is hard to exploit). We focus in this PhD work on the crawling and archiving of publicly accessible Web applications, especially those of the social Web. A Web application is any application that uses Web standards such as HTML and HTTP to publish information on the Web, accessible by Web browsers. Examples include Web forums, social networks, geolocation services, etc. We claim that the best strategy to crawl these applications is to make the Web crawler aware of the kind of application currently processed, allowing it to refine the list of URLs to process, and to annotate the archive with information about the structure of crawled content. We add adaptive characteristics to an archival Web crawler: being able to identify when a Web page belongs to a given Web application and applying the appropriate crawling and content extraction methodology.
An Electronic Simultaneous Equation Solver (1948)

An analogy device for directly solving simultaneous linear equations (without resorting to successive approximation methods) is described in this paper. It utilizes a number of high gain amplifiers interconnected by networks whose elements bear definite relationships to the known coefficients and constants of the system of equations. The stability criterion for such a system, and its application to an equation solver are described. Since the device produces the answers to a system of equations without delay, it is readily adaptable to problems of synthesis as well as those of analysis.
The Briard dog: a new animal model of congenital stationary night blindness. (1989)

Congenital stationary night blindness (CSNB), apparently inherited in an autosomal recessive manner, was observed in a litter of Briard dogs in Sweden. Of nine litter mates five had nyctalopia. The results of different clinical tests, including electroretinography (ERG), were compared with the results found in four human cases of CSNB, three of which were most probably associated with autosomal recessive inheritance and one with X-linked inheritance. The congenital and stationary nature of the disease, ophthalmoscopically normal appearing fundi, and recordable but reduced photopic flicker responses were some of the similarities found between canine and human cases. The single-flash ERG response was abnormal in the humans as well as in the affected Briards. However, the human cases showed a "negative' ERG, whereas in the Briards both the a and b waves were extremely reduced and present only at a photopic level. Cases similar to these Briards have been described also in man, where rhodopsin concentration and regeneration were found to be normal, suggesting a disturbed transduction mechanism. It thus appears that the Briard dog may become a valuable model of human CSNB.
ADC/DAC Loopback Linearity Testing by DAC Output Offsetting and Scaling (2010)

Loopback testing is a powerful technique for testing the analog-to-digital converter (ADC) and digital-to-analog converter (DAC) pair embedded in a mixed-signal system-on-chip (SoC). While attractive, its performance is generally limited by the achievable test resolution and the potential fault masking problem. In this work, a loopback linearity testing technique for an ADC/DAC pair is presented; the key idea is to raise the effective ADC and DAC resolution by scaling the DAC output. First, during ADC testing, we scale down the DAC output to achieve the required test stimulus resolution and adjust the DAC output offset to cover the ADC full-scale range. Then, for DAC testing, we raise the effective ADC resolution by scaling up the DAC output. Both simulation and measurement results are presented to validate the proposed technique.
A model of keyboard configuration requirements (1999)

This paper presents a user model: a computer program which examines the behaviour of a real computer user. The model encompasses four aspects of keyboard use which can present difficulties for people with motor disabilities. Where relevant keyboard configuration options exist, the model chooses appropriate settings for these options. The model bases its recommendations on observation of users typing free English text. It is intended to form part of a dynamic configuration support tool. Empirical evaluation showed the model to be very accurate in identification of a given user's difficulties. Where recommended configuration options were tried by the participants, high levels of error reduction and user satisfaction were found.
Structural adaptation of enzymes to low temperatures (2001)

A systematic comparative analysis of 21 psychrophilic enzymes belonging to different structural families from prokaryotic and eukaryotic organisms is reported. The sequences of these enzymes were multiply aligned to 427 homologous proteins from mesophiles and thermophiles. The net flux of amino acid exchanges from meso/thermophilic to psychrophilic enzymes was measured. To assign the observed preferred exchanges to different structural environments, such as secondary structure, solvent accessibility and subunit interfaces, homology modeling was utilized to predict the secondary structure and accessibility of amino acid residues for the psychrophilic enzymes for which no experimental three-dimensional structure is available. Our results show a clear tendency for the charged residues Arg and Glu to be replaced at exposed sites on alpha-helices by Lys and Ala, respectively, in the direction from 'hot' to 'cold' enzymes. Val is replaced by Ala at buried regions in alpha-helices. Compositional analysis of psychrophilic enzymes shows a significant increase in Ala and Asn and a decrease in Arg at exposed sites. Buried sites in beta-strands tend to be depleted of VAL: Possible implications of the observed structural variations for protein stability and engineering are discussed.
INVESTIGATION OF AN OUTBREAK OF SALMONELLA ENTERITIDIS GASTROENTERITIS ASSOCIATED WITH CONSUMPTION OF EGGS IN A RESTAURANT CHAIN IN MARYLAND (1988)

Salmonella enteritidis ser. enteritidis was isolated from patrons and employees of three restaurants in a restaurant chain in Maryland during August and September 1985. Isolates from all three restaurants had identical plasmid profiles; this profile was present in 13 of 40 randomly selected S. enteritidis isolates received by the Maryland state health department laboratory during a comparable time period. The outbreak in one restaurant resulted in at least 71 illnesses, with 17 persons known to have been hospitalized. Scrambled eggs served on a "breakfast bar" were implicated as the vehicle of transmission in this restaurant, with eggs a possible vehicle in another of the three restaurants. The data point out the risks associated with improper handling of eggs in food service establishments, provide further evidence for the observed association between S. enteritidis and eggs in the northeastern United States, and demonstrate the utility of plasmid analysis in investigation of outbreaks involving common Salmonella serotypes.
Systemic manifestations of hepatitis C infection (2016)

Chronic hepatitis C (HCV) is a common infection affecting 185 million people worldwide. The most common manifestation of chronic HCV is progressive liver fibrosis, cirrhosis, liver failure and hepatocellular carcinoma. However, several systemic manifestations of HCV have been recognized and reported in the literature. The purpose of this review is to assimilate published literature based on evidence to categorize these extrahepatic manifestations with the likelihood of a causal association with HCV. Exciting recent developments have resulted in simple all oral interferon-free highly effective therapy for HCV. However, this treatment is also expensive and less accessible to most affected individuals as treatment recommendations are based on stage of liver fibrosis. Expanding the scope of HCV therapy to those with extrahepatic manifestations beyond what is currently recommended will significantly reduce the morbidity and mortality in this aging population.
Joint speaker segmentation, localization and identification for streaming audio (2007)

In this paper we investigate the problem of identifying and localizing speakers with distant microphone arrays, thus extending the classical speaker diarization task to answer the question “who spoke when and where”. We consider a streaming audio scenario, where the diarization output is to be generated in realtime with as low latency as possible. Rather than carrying out the individual segmentation and classification tasks (speech detection, change detection, gender/speaker classification) sequentially, we propose a simultaneous segmentation and classification by applying a Viterbi decoder. It uses a transition matrix estimated online from position information and speaker change hypotheses, instead of fixed transition probabilites. This avoids early hard decisions and is shown to outperform the sequential approach.
A novel FPGA-based SVM classifier (2010)

Support Vector Machines (SVMs) are a powerful supervised learning tool, providing state-of-the-art accuracy at a cost of high computational complexity. The SVM classification suffers from linear dependencies on the number of the Support Vectors and the problem's dimensionality. In this work, we propose a scalable FPGA architecture for the acceleration of SVM classification, which exploits the device heterogeneity and the dynamic range diversities among the dataset attributes. Furthermore, this work introduces the first FPGA-oriented cascade SVM classifier scheme, which intensifies the custom-arithmetic properties of the heterogeneous architecture and boosts the classification performance even more. The implementation results demonstrate the efficiency of the heterogeneous architecture, presenting a speed-up factor of 2-3 orders of magnitude, compared to the CPU implementation, while outperforming other proposed FPGA and GPU approaches by more than 7 times.