gebhart/patrepeval huggingface dataset:
A SYSTEMS ENGINEERING APPROACH TO COMPACT AUXILIARY POWER UNITS FOR MILITARY APPLICATIONS (2024)

<title>ABSTRACT</title> <p>AVL is developing a family of modular Auxiliary Power Units (APUs) based on the current gasoline range extender engine/generator developed by AVL for plug-in hybrid electric vehicles. These military specific variants will utilize the same basic architecture as the gasoline version while incorporating semi-direct fuel injection that is compatible with diesel fuel as well as kerosene based fuels such as F-44, JP-5, JP-8, Jet-A, etc.</p> <p>A systems engineering approach to the engine, generator, and power electronics modules enables a wide range of power outputs and packaging options to be easily developed from the base unit.</p>
A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status (2015)

We identify a novel and statistically robust multi-tissue RNA signature of human healthy ageing that can act as a diagnostic of future health, using only a peripheral blood sample. This RNA signature has great potential to assist research aimed at finding treatments for and/or management of AD and other ageing-related conditions.
Successful replication of parvovirus B19 in the human megakaryocytic leukemia cell line MB-02 (1993)

The pathogenic human parvovirus B19 has been shown to undergo productive replication in the erythroid lineage in primary normal human hematopoietic progenitor cells. However, none of the established erythroleukemia cell lines has allowed B19 virus replication in vitro. The remarkable erythroid tissue tropism of B19 virus was evaluated with a human megakaryocytic leukemia cell line, MB-02, which is dependent on the growth factor granulocyte-macrophage colony-stimulating factor but can be induced to undergo erythroid differentiation following treatment with erythropoietin (Epo). Whereas these cells did not support B19 virus DNA replication in the presence of granulocyte-macrophage colony-stimulating factor alone, active viral DNA replication was observed if the cells were exposed to Epo for 5 to 10 days prior to B19 virus infection, as detected by the presence of the characteristic B19 virus DNA replicative intermediates on Southern blots. No replication occurred if the cells were treated with Epo for 3 days or less. In addition, complete expression of the B19 virus genome also occurred in Epo-treated MB-02 cells, as detected by Northern blot analysis. B19 progeny virions were released into culture supernatants that were biologically active in secondary infection of normal human bone marrow cells. The availability of the only homogeneous permanent cell line in which induction of erythroid differentiation leads to a permissive state for B19 virus replication in vitro promises to yield new and useful information on the molecular basis of the erythroid tissue tropism as well as parvovirus B19-induced pathogenesis.
Solid-state laser resonators with diffractive optic thermal aberration correction (1999)

A solid-state laser cavity is studied where the laser crystal aberrations are corrected by a diffractive optic element. The type of aberration and the location of the correction plate are found to significantly influence the modal performance of the cavity. The largest modal discrimination is obtained for axicon-like crystal aberrations and when the correction is performed close to the end mirror. An experiment is performed with a laser diode-pumped Nd:YVO/sub 4/ laser. With no correction, a thermal aberration of approximately two waves is measured across the crystal. By using a diffractive corrector plate, the single-mode slope efficiency is increased by a factor of 4, and the total single-mode output power is increased by a factor of 3.
Appendicitis complicating pregnancy. (1996)

Abdominal pain is a common symptom in pregnancy. Its etiology is diverse and diagnosis often poses a problem. Inflammatory disorders of extra-uterine origin such as appendicitis should always be considered as a possible cause. Three cases of appendicitis complicating pregnancy managed at the Queen Elizabeth Hospital, Barbados during the year 1993 are documented. Two presented in the antenatal period and the third postpartum. The clinical manifestations and the difficulties encountered in diagnosis are emphasised.
Angle-dependent irreversible magnetization of an La<sub>1.87</sub>Sr<sub>0.13</sub>CuO<sub>4</sub>single crystal (1993)

Using a vibrating-sample magnetometer, the irreversible magnetization of a disc-shaped La1.87Sr0.13CuO4 single-crystal specimen has been investigated for various angles theta between the direction of the applied field and the superconducting (Cu-O) plane. By separating the reversible and irreversible contributions from the measured magnetization induced by the applied field, the authors have shown that the change in the irreversible magnetic behaviour originates basically from the layered structure of the materials, and the geometrical effect on the irreversible properties is much smaller than that due to the intrinsic material anisotropy.
Oligo‐ and Polyselenophenes: A Theoretical Study (2009)

Recently, a family of conducting polyselenophenes was synthesized, and they were shown to have a number of interesting properties. Here we have studied oligoselenophenes, their cation radicals and dications up to the 50-mer (50 Se), as well as polyselenophene at the B3LYP/6-31G(d) level of theory, and compared them with the corresponding oligothiophenes. Although the calculations reveal many similarities between oligo- and polyselenophenes and their thiophene-based counterparts, they also show the important differences between those two types of conjugated systems. Oligo- and polyselenophenes have a more quinoid character, lower band gap, and importantly, they are more difficult to twist. The theoretical results suggest that the HOMO-LUMO gap (band gap), bond-length alternation (BLA), and charge distribution in oligo- and polyselenophenes are strongly dependent on inter-ring twisting, yet twisting costs little energy. The inter-ring distances in oligo- and polyselenophenes are shorter than the related distances in oligothiophenes, whereas the bond lengths within the selenophene rings are comparable to those of the corresponding oligothiophenes.
Transcatheter Aortic Valve Implantation and Subclinical and Clinical Leaflet Thrombosis: Multimodality Imaging for Diagnosis and Risk Stratification (2021)

In recent years, the phenomenon of subclinical leaflet thrombosis (SLT) in patients who have undergone transcatheter aortic valve implantation has become increasingly relevant. Hypo-attenuating leaflet thickening and hypo-attenuation affecting motion diagnosed by CT are the hallmarks of SLT, and their incidence varies depending on the intensity of screening. Whether these phenomena are a surrogate for leaflet thrombosis reducing valve durability and increasing the risk of stroke is still a matter of debate. Uncertainty remains over the optimal antithrombotic therapy after TAVI and the best treatment strategy is still not confirmed. Ongoing and future trials will provide more evidence about the best strategy for the prevention and treatment of SLT.
A cricket-inspired Neural Network For FeedForward Compensation and Multisensory Integration (2006)

A nonlinear feedforward compensator was designed as part of a bioinspired neural network to model sensorimotor integration and control in crickets. Female crickets perform auditory orientation (phonotaxis) towards the male's calling song to find a mate. Crickets also use visual sensing, for example in the optomotor reflex which allows them to maintain a straight trajectory against disturbances. The compensator describe in this paper allows the efficient integration of the phonotaxis and optomotor systems. The design is inspired by the neurophysiological concepts of efferent-copy and corollary discharge, which can be directly intepreted within control theory as feedforward compensation for predictable disturbances. The aim is to predict the reafferent visual stimulus caused by phonotaxis, based on the efferent response, thus filtering out the optical disturbances induced by the phonotactic reflex, while still detecting any external noise. The feedforward compensator design was formulated as an identification problem, drawing data from experiments on a robot performing phonotaxis. The compensator parameters were first derived by trial-and-error, and then optimised using a genetic algorithm. The scheme is implemented in a bioinspired neural network on a robot, and experiments are carried out to compare the behaviour to the cricket.
Can peroperative bevacizumab (AvastinTM) improve trabeculectomy outcome? A prospective, randomized, placebo‐controlled study (2010)

Abstract Purpose Glaucoma surgery fails in 30% due to excessive scar formation of the constructed channel. Our group found that vascular endothelial growth factor (VEGF) is upregulated in the aqueous humor of glaucoma patients and postoperatively in a rabbit model for trabeculectomy, that VEGF stimulates fibroblast proliferation in vitro whereas bevacizumab can inhibit their growth, and that a single peroperative intracameral injection of bevacizumab improves the surgical outcome of trabeculectomy in a rabbit model. Based on these findings, we set up a clinical trial to study the potential of bevacizumab as an anti‐scarring agent after trabeculectomy. Methods This is a prospective, randomized, placebo‐controlled, double‐blinded experimental study. The effect of peroperative administration of 50 µl of bevacizumab (25mg/ml) on intraocular pressure, bleb characteristics, as well as number of postoperative IOP‐lowering medications and surgical interventions is investigated. Patients with primary open‐angle glaucoma (POAG) and normal tension glaucoma (NTG) who are scheduled for primary trabeculectomy are included. Results Inclusions started on April 2009 and are still ongoing. Based on a priori calculations we need to include 124 patients. We already included 97 patients, 54 of which are POAG and 43 are NTG patients. By the end of September the majority will have ended the study. The preliminary results of this group will be presented at EVER. Conclusion This study will provide evidence on effectiveness and safety of single administration of bevacizumab during trabeculectomy to reduce the risk of surgical failure, avoiding or reducing the need for long‐term medication use or secondary surgical intervention.
A Comparison of Two Practical Multicast Routing Scheme (1994)

Designing an interdomain multicast routing scheme that makes efficient use of network resources while delivering good performance to applications is a significant challenge. A variety of schemes have been proposed, but little has been done to compare the schemes systematically over a rich set scenarios. In this work we develop a framework to do systematic evaluation of multicast routing schemes, and apply it to two practical schemes: Distance Vector Multicast Routing Procotol and Core Based Trees. We conclude that Core Based Trees has the potential to make more efficient use of resources, with modest performance penalty. However, this requires mechanisms to choose good cores. We suggest a heuristic for evaluating the goodness of a core and moving towards a good core.
Matched-phase noise reduction (1994)

A simple method is presented for improving signal-to-noise ratios in noise dominated data, given the shape of the noise spectrum. No a priori information about the signal is required, except that its spectrum be distinct from that of the noise. Under the condition that the noise spectrum is sufficiently well known, a numerical example is given in which a signal may be detected despite a signal-to-noise ratio less than −100 dB.
Statistical similarity and cross-spectral purity of stationary stochastic fields (2012)

In practical situations, one often generates a beam by superposition of two or more light beams. The beam generated by superposition displays, in general, different spectral properties than do the original beams. However, there are some optical beams, called cross-spectrally pure beams, which can generate a light beam of identical spectral distribution on superposition. The relationship between cross-spectral purity and spatial coherence has been the subject of investigations for some time. Recently, a concept of so-called statistical similarity has been introduced which provides a new way to elucidate complete spatial coherence. In this Letter, we discuss some implications of statistical similarity of an optical field on its cross-spectral purity.
Processing and Sintering of Sol-Gel Derived Lithium Aluminosilicate Powders (2008)

The goals of this research are threefold: a) production of lithium aluminosilicate (LAS) glass-ceramics via a sol-gel process, b) densification to near theoretical density without hot-pressing; and c) fabrication of dense, SiC whisker-reinforced LAS composites with greater than 25 vol% whisker content. This paper discusses the first two aspects of this research; the work on densification of whisker-reinforced LAS composites will be reported at a future date. Three sol-gel approaches were investigated to produce β-Eucryptite LAS glass-ceramics. These approaches differed in the oxide precursors used for processing. Cast xerogels and ultrafine powders of 1:1:2 Li2O:Al2O3:SiO2 β-Eucryptite were successfully produced. The most successful technique was an all-alkoxide approach in which an alcoholic solution of tetraethoxysilane (TEOS), aluminum sec-butoxide (ASB), and lithium methoxide were combined. Greater than 90% of theoretical density was achieved from cold pressed and sintered β-Eucryptite oxide powders. X-ray diffraction analysis indicated crystallization had occurred in all the sintered samples.
Surgery for hyperthyroidism: Hemithyroidectomy plus contralateral resection or bilateral resection? A prospective randomized study of postoperative complications and long‐term results (1992)

Abstract Fifty consecutive patients undergoing surgical treatment for hyperthyroidism were randomized to have either bilateral subtotal resection (n=23) or hemithyroidectomy plus contralateral resection (n=27). No significant differences in operating time or intra‐operative bleeding were found. No postoperative bleeding and no temporary or persistent recurrent laryngeal nerve paralysis occurred. Four patients who underwent bilateral resection and 2 patients who had hemithyroidectomy resection needed temporary calcium supplementation, and the serum calcium concentrations were slightly lower during the first few postoperative days in the patient undergoing hemithyroidectomy/resection. No persistent hypocalcemia occurred in either of the groups. At follow‐up 3–4 years (mean 3.6 years) postoperatively, 1 patient in the bilateral resection group developed recurrent hyperthyroidism; no patients in the hemithyroidectomy/resection group developed recurrent hyperthyroidism. Twelve (44%) patients in the hemithyroidectomy/resection group and 8 (35%) patients in the bilateral resection group needed thyroxine supplementation because of a rise in thyroid stimulating hormone concentration combined with clinical signs of hypothyroidism that developed during follow‐up. Hyperthyroidism can be treated by hemithyroidectomy plus contralateral resection without increasing the risk of complications. The results also suggest that when using this method, a slightly larger thyroid remnant should be left to avoid an increase in the incidence of hypothyroidism postoperatively.
β<sub>1</sub> Integrin‐mediated lymphocyte adherence to extracellular matrix is enhanced by phorbol ester treatment (1991)

The interaction of the human T cell leukemia, Jurkat, with the extracellular matrix components collagen and fibronectin was examined. These cells displayed constitutive binding to fibronectin and low levels of adherence to collagen which were enhanced following stimulation with phorbol esters. The relevant binding structures were identified as members of the CD29/beta 1 integrin family of adhesion molecules. Adherence to collagen and to fibronectin was mediated by alpha 2 beta 1 and alpha 5 beta 1, respectively. The enhancement of adherence by phorbol esters did not involve up-regulation of receptor expression but appeared to derive from the increased functionality of structures which were expressed on the cell surface.
Homologous desensitization of signalling by the alpha (α) isoform of the human thromboxane A2 receptor: A specific role for nitric oxide signalling (2007)

Thromboxane (TX) A(2) plays a central role in hemostasis, regulating platelet activation status and vascular tone. We have recently established that the TP beta isoform of the human TXA(2) receptor (TP) undergoes rapid, agonist-induced homologous desensitization of signalling largely through a G protein-coupled receptor kinase (GRK) 2/3-dependent mechanism with a lesser role for protein kinase (PK) C. Herein, we investigated the mechanism of desensitization of signalling by the TP alpha isoform. TP alpha undergoes profound agonist-induced desensitization of signalling (intracellular calcium mobilization and inositol 1,4,5 trisphosphate generation) in response to the TXA(2) mimetic U46619 but, unlike that of TP beta, this is independent of GRKs. Similar to TP beta, TP alpha undergoes partial agonist-induced desensitization that occurs through a GF 109203X-sensitive, PKC mechanism where Ser(145) within intracellular domain (IC)(2) represents the key phospho-target. TP alpha also undergoes more profound sustained PKC- and PKG-dependent desensitization where Thr(337) and Ser(331), respectively, within its unique C-tail domain were identified as the phospho-targets. Desensitization was impaired by the nitric oxide synthase (NOS), soluble guanylyl cyclase (sGC) and PKG inhibitors L-NAME, LY 83583 and KT5823, respectively, indicating that homologous desensitization of TP alpha involves nitric oxide generation and signalling. Consistent with this, U46619 led to rapid phosphorylation/activation of endogenous eNOS. Collectively, data herein suggest a mechanism whereby agonist-induced PKC phosphorylation of Ser(145) partially and transiently impairs TP alpha signalling while PKG- and PKC-phosphorylation at both Ser(331) and Thr(337), respectively, within its C-tail domain profoundly desensitizes TP alpha, effectively terminating its signalling. Hence, in addition to the agonist-mediated PKC feedback mechanism, U46619-activation of the NOS/sGC/PKG pathway plays a significant role in inducing homologous desensitization of TP alpha.
Systemic Therapy for Non–Clear Cell Renal Cell Carcinoma (2017)

Treatment options for metastatic clear cell renal cell carcinoma (ccRCC) have evolved markedly over the past decade, with multiple targeted therapies approved for the disease. In contrast, little improvement has been made in the management of metastatic non–clear cell RCC (nccRCC). Non–clear cell disease is an umbrella term that encompasses multiple biologically distinct entities, including but not limited to papillary, chromophobe, and sarcomatoid RCC. To date, prospective studies have largely explored treatments for ccRCC (e.g., VEGF- and mTOR-directed therapies) in trials that aggregate non–clear cell histologies. However, the studies do not acknowledge the varying biology of each non–clear cell subtype. Emerging studies in nccRCC should examine individual histologies and apply biologically relevant therapies. An example of this is SWOG 1500, a randomized phase II study that will compare a VEGF-inhibitor to one of three MET-directed therapies in patients with metastatic papillary RCC. Until the biologic diversity of nccRCC is appreciated, outcomes are likely to remain dismal.
[Franklin's disease associated with chronic active hepatitis and hypothyroidism. One case (author's transl)]. (1979)

The authors report on a new case of Franklin's disease; the originality of which lies in the fact that it was associated with hypothyroïdism and mainly with B virus chronic active hepatitis. It seems likely that chronic antigenic stimulation during active hepatitis played role in the pathogenesis of the monoclonal gammapathy.
Angiotensin II AT<sub>1</sub> receptor antagonism prevents detrimental renal actions of acute diuretic therapy in human heart failure (2003)

Although effective in relieving symptoms of edema in congestive heart failure (CHF), diuretic-induced natriuresis may be associated with reductions in glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), which subsequently may reduce the duration of natriuresis. Moreover, recent studies have reported that the preservation of GFR is an important predictor of survival in human CHF. We hypothesized that the acute detrimental renal hemodynamic and tubular responses to furosemide in symptomatic human CHF will be attenuated by AT(1) receptor blockade with losartan. We defined the renal hemodynamic and tubular actions and aldosterone responses to furosemide (40 mg, orally) in the presence of acute AT(1) receptor antagonism (losartan, MSD, 50 mg orally) vs. placebo in 10 subjects with CHF (New York Heart Association II-III) in a double-blind, placebo-controlled crossover study. Furosemide with placebo increased sodium excretion and reduced ERPF and GFR (P < 0.05 vs. baseline). After 4 h, sodium excretion compared with baseline was decreased (P < 0.05). In contrast, furosemide with losartan resulted in a greater increase in sodium excretion but without reductions in ERPF and GFR (P < 0.05 vs. placebo). After 4 h, sodium excretion was greater compared with the placebo group. Importantly, plasma aldosterone tended to increase in the placebo group, whereas it was decreased (P < 0.05 vs. baseline) only in the losartan group. These studies underscore the pathophysiological role of the AT(1) receptor in mediating detrimental renal and adrenal properties of diuretics in human CHF. AT(1) receptor antagonism preserves GFR and renal blood flow and enhances sodium excretion during acute diuretic therapy in addition to inhibiting aldosterone secretion. These findings support the use of AT(1) receptor blockade for human CHF requiring acute diuretics to improve renal hemodynamic and tubular function and to suppress aldosterone.
Fondements de la mécanique des sols (2006)

(2006). Fondements de la mecanique des sols. Revue Europeenne de Genie Civil: Vol. 10, No. 1, pp. 111-112.
Low-Loss Ti:LiNbO3 Waveguide Bends at λ = 1.3 μm (1982)

Low-loss waveguide bends are necessary for many proposed integrated optical circuits to improve the packing density, and for certain devices, e.g., directional couplers. Previous bend loss measurements have been reported for Ti: LiNbO 3 at λ = 0.633 μm and 1.06 μm, with losses as low as 0.3 ± 0.3 dB for an S-shaped transition between straights separated by 3 mm longitudinally with an lateral offset of 0.10 mm. 1 For comparable transition regions bend losses of 2-3 dB were measured using two constant curvature segments, 2 4 dB using a straight-segment transition, 3 and 1.8 dB using three straight segments with coherent coupling. 4
Formation of Polymer Walls by Phase Separation of Lc-Polymer Binary Mixtures in a Nonuniform Electric Field (1999)

Abstract We investigated the mechanism of polymer wall formation induced by an inhomogeneous electric field. The patterned electric field drives the phase separation of a liquid crystal-polymer mixture. By proper selection of polymer and liquid crystal, polymer walls can be formed in the interpixel region of a multiplex display. We found that difference in the dielectric properties of the LC and polymer components of the mixtures in conjunction with gradient of the electric field results in formation of the polymer walls. We discuss factors controlling the phase separation process such as concentration, temperature and electric field.