gebhart/patrepeval huggingface dataset:
Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma (2009)

Owing to the rarity of adrenocortical carcinoma (ACC) no prognostic markers have been established beyond stage and resection status. Accelerated glycolysis is a characteristic feature of cancer cells and in a variety of tumour entities key factors in glucose metabolism like glucose transporter 1 and 3 (GLUT1 and -3), transketolase like-1 enzyme (TKTL1) and pyruvate kinase type M2 (M2-PK) are overexpressed and of prognostic value. Therefore, we investigated the role of these factors in ACC. Immunohistochemical analysis was performed on tissue microarrays of paraffin-embedded tissue samples from 167 ACCs, 15 adrenal adenomas and 4 normal adrenal glands. Expression was correlated with baseline parameters and clinical outcome. GLUT1 and -3 were expressed in 33 and 17% of ACC samples respectively, but in none of the benign tumours or normal adrenals glands. By contrast, TKTL1 and M2-PK were detectable in all benign tissues and the vast majority of ACCs. GLUT1 expression was strongly associated with prognosis in univariate and multivariate analysis (P<0.01), whereas GLUT3, TKTL1 and M2-PK did not correlate with clinical outcome. Patients with strong GLUT1 staining showed a considerably higher overall mortality (hazard ratio (HR) 6.34 (95% confidence interval 3.10-12.90) compared with patients with no GLUT1 staining. When analysing patients in their early stages and advanced disease separately, similar results were obtained. HR for survival was 5.31 (1.80-15.62) in patients with metastatic ACC and in patients after radical resection the HR for disease-free survival was 6.10 (2.16-16.94). In conclusion, GLUT1 is a highly promising stage-independent, prognostic marker in ACC.
EmailProfiler: Spearphishing Filtering with Header and Stylometric Features of Emails (2016)

Spearphishing is a prominent targeted attack vector in today's Internet. By impersonating trusted email senders through carefully crafted messages and spoofed metadata, adversaries can trick victims into launching attachments containing malicious code or into clicking on malicious links that grant attackers a foothold into otherwise well-protected networks. Spearphishing is effective because it is fundamentally difficult for users to distinguish legitimate emails from spearphishing emails without additional defensive mechanisms. However, such mechanisms, such as cryptographic signatures, have found limited use in practice due to their perceived difficulty of use for normal users. In this paper, we present a novel automated approach to defending users against spearphishing attacks. The approach first builds probabilistic models of both email metadata and stylometric features of email content. Then, subsequent emails are compared to these models to detect characteristic indicators of spearphishing attacks. Several instantiations of this approach are possible, including performing model learning and evaluation solely on the receiving side, or senders publishing models that can be checked remotely by the receiver. Our evaluation of a real data set drawn from 20 email users demonstrates that the approach effectively discriminates spearphishing attacks from legitimate email while providing significant ease-of-use benefits over traditional defenses.
iPSC derived CM and features of cell sheet. (2015)

<p><b>A</b>: Construction of lentiviral vector expressing ZsGreen1 (green fluorescence) under the control of a CM-specific promoter (NCX1). The final construct contained the CM-specific promoter (NCX1) driving firefly luciferase (pLVX-NCX1-Fluc-PuroR-IRES-ZsGreen1). NCX1 = sodium-calcium exchanger promoter. Fluc = firefly luciferase; <b>B</b>: EB from iPSC on day 5 were used to determine efficiency of NCX1/GFP on iPSC-derived CM selection under immunofluorescent microscopy (Left panel). On Day 15 differentiated CM cells were analyzed by flow cytometry selecting for α-actinin positive cells (Right panel). <b>C</b>: The cardiac gene expression profile in iPSC-derived CM was assessed by qPCR. Quantitative data for Nkx2.5, GATA4, ACTC, and α-MHC expression at day 15 after iPSC differentiation. All values expressed as mean ± SEM. n = 6 for each group. <b>D</b>: iPSC-CM sheet was cultured on temperature-responsive culture dishes and the cell sheets spontaneously detached as monolayer cell sheet when the temperature was lowered to 20°C for 30 min (Left). Cell sheets were approximately 10 mm in diameter (Left) with a 30 µm thickness (Right). <b>E</b>: Scanning electron microscopic image of iPSC-CM sheet (Left) and ischemic heart tissue 4 weeks after implantation of iPSC-CM sheet (Right).</p>
Transport properties of two-dimensional electron systems on silicon (111) surfaces (2007)

We theoretically study transport properties of a two-dimensional electron system on a hydrogen-passivated Si(111) surface in the field-effect-transistor (FET) configuration. We calculate the density- and temperature-dependent mobility and resistivity for the recently fabricated Si(111)-vacuum FET by using a semiclassical Boltzmann theory including screened charged impurity scattering. We find reasonable agreement with the corresponding experimental transport properties, indicating that the screened disorder potential from random charged impurities is the main scattering mechanism. We also find that the theoretical results with the valley degeneracy ${g}_{v}=2$ give much better agreement with the experimental transport data than the ${g}_{v}=6$ situation, indicating that the usual bulk six-valley degeneracy of Si is lifted in this system.
Effect of curing mode on bond strength of self‐adhesive resin luting cements to dentin (2010)

In this study, the in vitro bond strength of dual-curing resin cements to indirect composite restorations when the cement was either light polymerized or allowed to only autopolymerize was evaluated. Occlusal dentin surfaces of 56 extracted human third molars were flattened to expose coronal dentin. Teeth were assigned to eight groups (n = 7) according to resin cement products and polymerization modes: conventional cement (Panavia F 2.0; Kuraray Medical) and self-adhesive cements [RelyX Unicem (3M ESPE), BisCem (Bisco), and G-Cem (GC Corp.)]. Cements were applied to prepolymerized resin discs (2-mm-thick Sinfony; 3M ESPE), which were subsequently bonded to the prepared dentin surfaces. The restored teeth were either light-polymerized through the overlying composite according to manufacturers' instructions or were allowed to only self-cure. After 24 h, the teeth and restorations were sectioned to obtain multiple bonded beams (1.0 mm(2)) and tested in tension at a crosshead speed of 0.5 mm/min until failure. Data (MPa) were analyzed by two-way ANOVA and Tukey test (alpha = 0.05). Light activation of some cement systems (G-Cem and Panavia F 2.0) increased the bond strength, while the curing mode did not affect the bond strength for some (RelyX Unicem and BisCem). The bond strength in the autopolymerized mode varied among products. In general, the use of self-adhesive resin cements did not provide significantly higher bond strengths than that of a conventional material, and two self-adhesive cements yielded significantly lower bond values (regardless of cure mode) than the other products.
The Effect of Particle Size on the Movement of a Striped Pattern Deposition Layer in an Aerosol Flow. (1997)

The effect of particle size on a particle layer moving along the inside wall was studied as a simultaneous phenomenon of particle deposition and reentrainment in a turbulent aerosol flow. The fine powder was dispersed in an air flow and fed into a glass tube, and the following features were found through observation using a video-microscope and image analysis.The movement of a striped pattern particle deposition layer is proportional to the particle flux moving toward the inside wall. Furthermore, the velocity of a moving particle layer is correlated with particle size. Finally, the size of the reentrained aggregate caused by the collision of one particle can be estimated by the particle layer transfer velocity and the particle deposition flux. The size of the reentrained aggregate decreases as air velocity increases.
The use of genetically engineered model systems for research on human aging (2008)

A major goal in the field of aging research is to identify molecular mechanisms of aging at the cellular level, which are anticipated to form the basis for the development of age-associated dysfunctions and diseases in human beings. Recent progress in research into model organisms of aging has allowed determining precise molecular mechanisms and genetic determinants of the aging process, which appear to be conserved in evolution and some of which apply to human aging as well. The consortium of the authors focuses on aging mechanisms at the cellular level, and exploits the potential of genetic analyses in lower eukaryotic model organisms for a better understanding of regulatory pathways implicated in aging processes. We have established a new database (GiSAO), which provides a unique resource for the analysis of genome-wide expression patterns as being regulated by senescence, apoptosis and oxidative stress in our model systems. This has led to the identification of candidate genes, which are being tested for their impact on lifespan regulation in yeast, the fruit fly Drosophila melanogaster and the nematode C. elegans.
Bioresorbable vascular scaffolds versus everolimus-eluting metallic stents in patients with ST-segment elevation myocardial infarction: 5-year results of the BVS-EXAMINATION study (2020)

The five-year event risk was higher with BRS versus EES in STEMI. This suggests that the probability of obtaining favourable results at very long-term follow-up is low. Whether better results will be obtained with new-generation BVS remains to be determined.
A high throughput assay for the TNF converting enzyme (2000)

Tumor necrosis factor-α (TNFα) has been implicated in cancer and inflammatory diseases since it was first characterized and eventually identified by researchers in several laboratories in the mid-1980s [1-5]. However, only recently has the patho-logical role of TNF in arthritis and Crohn’s disease been demonstrated in the clinic with the FDA’s approval of Enbrel and Remicade [6-8]. The recent success of these biological agents that neutralize TNF has led to intense efforts to find small molecule TNF antagonists that will mimic the consequences, if not the mechanism, of these agents. Because TNF interacts at multiple contact points with either of its two receptors, researchers have struggled to find small molecular weight inhibitors that antagonize this interaction. Therefore, most efforts have focused on targets upstream of TNF synthesis or secretion and downstream of TNF receptor engagement since these targets appear more amenable to modulation by small molecular weight inhibitors [9].
Abstract 2550: Combination of the KSP inhibitor ARRY-520 with bortezomib causes sustained tumor regressions and significantly increased time to regrowth in bortezomib sensitive and resistant models of multiple myeloma (2011)

Abstract The allosteric kinesin spindle protein (KSP) inhibitor ARRY-520 has potent antitumor activity as a single agent in xenograft models of multiple myeloma, with complete response rates as high as 100%. It has shown promising signs of activity in a phase 1 trial in patients with advanced / refractory multiple myeloma, and a phase 2 study in this patient population is in progress. We report here on the striking activity of ARRY-520 in combination with bortezomib in multiple myeloma xenograft models. We investigated the activity of the combination of ARRY-520 with bortezomib in several xenograft models of multiple myeloma that are sensitive (Kas-6, ANBL-6, and H929) and resistant (RPMI8226, JJN3, a subline of ANBL-6 made resistant to bortezomib by in vitro treatment, and a subline of RPMI8226 that acquired a PI3K activating mutation) to bortezomib. The combination of ARRY-520 with bortezomib showed additive or superadditive activity, compared to either drug alone, in 6 of the 7 models tested. Complete responses and cures were observed in several models. The Kas-6 model was particularly sensitive, with a 100% cure rate (complete response through day 100). Since previous work from our lab (Mol. Cancer Ther. 9(7), 2046, 2010) implicates MCL1 status as a predictor of response to ARRY-520 in multiple myeloma cell lines, we evaluated the effect of the ARRY-520 + bortezomib combination on MCL1 and other markers of apoptosis. Treatment with the combination resulted in elevation of the cleaved / full length PARP ratio (up to 15X), compared to tumors treated with the single agents, along with a decline in MCL1 levels that coincided with elevation of the level of a 28kd fragment of MCL1 (up to 17X). This shortened form of MCL1 has been reported to be pro-apoptotic. Thus, the cleavage of MCL1 to a proapoptotic form, leading to a decrease in survival signaling and an increase in apoptotic signaling, may play a role in the activity of the ARRY-520 + bortezomib combination. The observation that the combination remained highly active even in models that were poorly responsive to single agent bortezomib suggests that the mechanisms underlying resistance to bortezomib may be distinct from those that contribute to activity of the combination. These results support ARRY-520 + bortezomib as a rational combination for clinical evaluation, including in patients with bortezomib-refractory disease. A phase 1 trial to evaluate the combination of ARRY-520 + bortezomib + dexamethasone is in progress. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2550. doi:10.1158/1538-7445.AM2011-2550
An accurate large-signal model for a high-efficient Si bipolar GSM power transistor (2002)

We present an accurate large-signal modelling approach for Si bipolar RF power transistors. An equivalent circuit model of a state of the art GSM power transistor (900 MHz, 3.5 V, 4 W, 70%) is constructed. The model is verified with accurate load pull measurements. Large-signal parameters (P/sub out/, G/sub T/, PAE) are predicted accurately.
Investigation of the Electrochemical Reduction of [Cp*Re(CO)2(p-N2C6H4OMe)][BF4] by Scanning Electrochemical Microscopy (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of the Electrochemical Reduction of [Cp*Re(CO)2(p-N2C6H4OMe)][BF4] by Scanning Electrochemical MicroscopyThomas C. Richards, Allen J. Bard, Antonio Cusanelli, and Derek SuttonCite this: Organometallics 1994, 13, 3, 757–759Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/om00015a006https://doi.org/10.1021/om00015a006research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ion transfer processes at ionic liquid based redox active drop deposited on an electrode surface (2005)

Ion transfer across the boundary formed at an ionic liquid drop deposited on an electrode immersed in aqueous solution, generated by electrochemical redox reaction at the electrode-ionic liquid interface, is studied to obtain information about the ability of anions to be transferred into a room temperature ionic liquid.
1.3-μm spot-size converter integrated laser diodes (SS-LDs) for access network applications (2002)

We have developed spot-size converter integrated laser diodes (SS-LDs) that include a mechanism for matching the optical field with the fiber and the planar lightwave circuit (PLC). We report the achievement of: reproducible lasing characteristics from 2-inch wafers; stable characteristics up to high temperature; and long-term stability at 85/spl deg/C. The taper-layer in the SS region is butt-jointed to the active layer. The merit of the butt-joint structure is that it allows the independent structural optimization of the active and SS regions. The active layer consists of compressive strained multi-quantum-well (MQW) structure with 8 wells to increase the maximum operation temperature effectively. The strain is 1.2% in InGaAsP wells, which are 6-nm thick. The taper layer consists of a 1.1-/spl mu/m-bandgap bulk layer. The taper-layer thickness changes exponentially from the butt-joint portion to the front facet, which effectively reduces radiation loss in the SS region.
Préparation de membranes poreuses cationiques par fonctionnalisation de poly(éther imide) (2013)

National audience
Biophysical Stimulation for Engineering Functional Skeletal Muscle (2017)

Tissue engineering is a promising therapeutic strategy to regenerate skeletal muscle. However, ex vivo cultivation methods typically result in a low differentiation efficiency of stem cells as well as grafts that resemble the native tissues morphologically, but lack contractile function. The application of biomimetic tensile strain provides a potent stimulus for enhancing myogenic differentiation and engineering functional skeletal muscle grafts. We reviewed integrin-dependent mechanisms that potentially link mechanotransduction pathways to the upregulation of myogenic genes. Yet, gaps in our understanding make it challenging to use these pathways to theoretically determine optimal ex vivo strain regimens. A multitude of strain protocols have been applied to in vitro cultures for the cultivation of myogenic progenitors (adipose- and bone marrow-derived stem cells and satellite cells) and transformed murine myoblasts, C2C12s. Strain regimens are characterized by orientation, amplitude, and time-dependent factors (effective frequency, duration, and the rest period between successive strain cycles). Analysis of published data has identified possible minimum/maximum values for these parameters and suggests that uniaxial strains may be more potent than biaxial strains, possibly because they more closely mimic physiologic strain profiles. The application of these biophysical stimuli for engineering 3D skeletal muscle grafts is nontrivial and typically requires custom-designed bioreactors used in combination with biomaterial scaffolds. Consideration of the physical properties of these scaffolds is critical for effective transmission of the applied strains to encapsulated cells. Taken together, these studies demonstrate that biomimetic tensile strain generally results in improved myogenic outcomes in myogenic progenitors and differentiated myoblasts. However, for 3D systems, the optimization of the strain regimen may require the entire system including cells, biomaterials, and bioreactor, to be considered in tandem.
‘What have you HEARD about the HERD?’ Does education about local influenza vaccination coverage and herd immunity affect willingness to vaccinate? (2018)

Education about herd immunity and local vaccination coverage could be a useful tool for increasing willingness to vaccinate, generating benefits both to individuals and communities.
Computation of cofactors of [sI-A] with applications (1979)

The cofactors of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[sI-A]</tex> are the key to accurate, efficient calculation of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[sI- A]^{-1}</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\partial \lambda/\partial a_{ij}</tex> , where a <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ij</inf> is an element of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">A</tex> . These cofactors can be evaluated by transforming their equivalents to phase variable or quasi-phase variable form. The procedure for forming the equivalent cofactors is the principal topic of this note.
The Investment Climate in Brazil, India, and South Africa (2006)

Finance and Financial Sector Development-Access to Finance International Economics and Trade-Trade Policy Macroeconomics and Economic Growth-Fiscal & Monetary Policy Macroeconomics and Economic Growth-Taxation & Subsidies Private Sector Development-Competitiveness and Competition Policy Private Sector Development-Legal Regulation and Business Environment Social Protections and Labor-Labor Markets
Adsorption Measurements of Methane on Activated Carbon in the Temperature Range (281 to 343) K and Pressures to 1.2 MPa (2010)

The adsorption characteristics of methane on a Maxsorb II specimen of activated carbon were measured over the temperature range of (281 to 343) K and at pressures up to 1.2 MPa using a new volumetric measurement system. The adsorbent was characterized through properties such as the skeletal density, Brunauer−Emmett−Teller (BET) surface area, and pore-size distribution. The adsorption data were fitted to two isotherm models proposed by Tóth and Dubinin−Astakhov with a predictive accuracy of better than 3 %. The present data were compared with those of various researchers with comparable specimens and found to be consistent with those in the open literature. The present data could complement efforts in designing adsorbed natural gas storage systems.
Risk Policy and Long-Term Investment (1981)

Empirical tests of the Sharpe [36]–Lintner [23]–Black [3] Capital Asset Pricing Model (CAPM) have generally concluded that there is a positive, approximately linear, trade-off between average return and systematic risk (beta) for portfolio returns of common stocks. Most of the empirical studies, however, have reported data for short, usually monthly, time intervals. Exceptions to this rule include Blume and Friend [8] and Sharpe [38, pp. 289–292]. Their data provide evidence that long-term wealth ratios are concave, possibly nonmonotonic, functions of beta. These data are surprising since, if returns are intertemporally independent and the linear return model of CAPM is correct, expected multiperiod terminal wealth is a convex, monotone increasing function of beta. The results of this paper provide a theoretical framework for interpreting the long-term empirical data which does not violate the notion of a monotone increasing expected terminal wealth-beta relationship.
Tumor initiierende Zellen beim kolorektalen Karzinom – Gibt es Hinweise für eine frühe Dissemination? (2010)

Einleitung und Ziele: Ausgelöst durch die aktuell kontrovers geführte Diskussion um die Frage der Tumorzelldissemination durch nodale und nicht-nodale Metastasierungsvorgänge eines Tumorgeschehens wurde die Frage sinnvoller darauf hinweisender Marker zur Klärung dieser Hypothese als auch der Frage disseminierter Tumorstammzellen für Patienten mit kolorektalem Karzinom (CRC) gestellt.