gebhart/patrepeval huggingface dataset:
Changes in protein synthetic activity in early <i>Drosophila</i> embryos mutat for the segmentation gene <i>Krüppel</i> (1988)

We have identified early embryo proteins related to the segmentation gene Krüppel by [35S]methionine pulse labelling and two-dimensional gel electrophoresis. Protein synthesis differences shared by homozygous embryos of two Krüppel alleles when compared to heterozygous and wild-type embryos are reported. The study was extended to syncytial blastoderm stages by pulse labelling and gel analysis of single embryos, using Krüppel-specific proteins from gastrula stages as molecular markers for identifying homozygous Krüppel embryos. Localized expression of interesting proteins was examined in embryo fragments. The earliest differences detected at nuclear migration stages showed unregulated synthesis in mutant embryos of two proteins that have stage specific synthesis in normal embryos. At the cellular blastoderm stage one protein was not synthesized and two proteins showed apparent shifts in isoelectric point in mutant embryos. Differences observed in older embryos included additional proteins with shifted isoelectric points and a number of qualitative and quantitative changes in protein synthesis. Five of the proteins with altered rates of synthesis in mutant embryos showed localized synthesis in normal embryos. The early effects observed are consistent with the hypothesis that the Krüppel product can be a negative or positive regulator of expression of other loci, while blastoderm and gastrula stage shifts in isoelectric point indicate that a secondary effect of Krüppel function may involve post-translational modification of proteins.
Seleção de isolados de Beauveria bassiana (Bals.) Vulll. e Metarhizium anisopliae (Metsch.) Sorok. para controle de Cornitermes cumulans (Kollar, 1832) (Isoptera - Termitidae) (1992)

Selection of Beauverio bassiana (Dais.)Vuili.And Metarhizium uni- sopliae (Metsch.)Sorok.Isoiates to contrai of Cornitermes cumulans (KoUar, 1832) (Isoptera -Termitidae)In 2 laboratory bioassays,. 1 isoiate of Beauveriabassiana and 3 isolates of Metarhizit,ra onisopliae were .selectedby consideririg virulence to Cornitermes cumulans (an important brazilian pastures pest) .For each isolate 59 of pure conidia was appiied per coiony of C. cumulans in the fieid.Tem days after appiication, we observed 130% termite rnortaiity and a high value for the conidiogenesis index on cadavers within the nests.
Realizing Freeform: A LWIR Imager in a Spherical Package (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text K. Fuerschbach, J. P. Rolland, and K. P. Thompson, "Realizing Freeform: A LWIR Imager in a Spherical Package," in Renewable Energy and the Environment, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper FW1B.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Get Video Citation alert Save article
On the representation of droplet coalescence and autoconversion: Evaluation using ambient cloud droplet size distributions (2009)

In this study, we evaluate eight autoconversion parameterizations against integration of the Kinetic Collection Equation (KCE) for cloud size distributions measured during the NASA CRYSTAL‐FACE and CSTRIPE campaigns. KCE calculations are done using both the observed data and fits of these data to a gamma distribution function; it is found that the fitted distributions provide a good approximation for calculations of total coalescence but not for autoconversion because of fitting errors near the drop‐drizzle separation size. Parameterizations that explicitly compute autoconversion tend to be in better agreement with KCE but are subject to substantial uncertainty, about an order of magnitude in autoconversion rate. Including turbulence effects on droplet collection increases autoconversion by a factor of 1.82 and 1.24 for CRYSTAL‐FACE and CSTRIPE clouds, respectively; this enhancement never exceeds a factor of 3, even under the most aggressive collection conditions. Shifting the droplet‐drizzle separation radius from 20 to 25 μ m results in about a twofold uncertainty in autoconversion rate. The polynomial approximation to the gravitation collection kernel used to develop parameterizations provides computation of autoconversion that agree to within 30%. Collectively, these uncertainties have an important impact on autoconversion but are all within the factor of 10 uncertainty of autoconversion parameterizations. Incorporating KCE calculations in GCM simulations of aerosol‐cloud interactions studies is computationally feasible by using precalculated collection kernel tables and can quantify the autoconversion uncertainty associated with application of parameterizations.
Efficiency/cost trade-off design of a multiple-active-bridge converter for smart transformer (2018)

The modular Smart Transformer (ST) is composed by several basic converters rated for lower voltage and power. In this paper the quadruple active bridge (QAB) is used as the basic block for the modular ST. In this application, the efficiency and cost are the most important design parameters. Therefore, the paper focus on the design of the converter, with the aim to optimize its efficiency, taking the cost into consideration. To do so, the losses of all components are carefully modeled and a computer-aided design is used, where an algorithm to calculate the losses and cost is developed, allowing to perform multi-objective optimization. Additionally, Silicon IGBTs and Silicon Carbide MOSFETs are considered for the design and the performance of the converter using both semiconductors technology is compared. Experimental results obtained for the optimized 20 kW QAB converter has shown an efficiency of 97.5%.
Bosanquet, Theodora, 1909 May 10 (1909)

copy of published letter from Jobe, August 2000; transcription only; letter of reference for Bosanquet—not addressed to her, but addressee is unknown
ChemInform Abstract: Preparation of Enantiomerically Enriched Compounds by Using Enzymes. Part 14. A Synthesis of (‐)‐Sitophilate by Utilizing Yeast‐Mediated Reduction of an Enol Ester. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Seasonal Changes of Bioluminescence in Photosynthetic and Heterotrophic Dinoflagellates at San Clemente Island (2012)

Seasonal Changes of Bioluminescence in Photosynthetic and Heterotrophic Dinoflagellates at San Clemente Island
Rodent Models of Obesity (2003)

Since publication of the initial chapter on animal models in 1998 (1), there has been an explosive increase in the number of animal models in mice. This has arisen from two major avenues of research-the use of transgenic and gene-targeting approaches for proof of function for several genes that were thought to alter energy balance or through the use of similar approaches to study genes that had not previously been associated with obesity but in which a phenotype of altered body composition and/or food intake has emerged. These genes (Table 1) have a wide range of functions including eﬀects on food intake, energy expenditure and physical activity, tissue metabolism, and adipose tissue diﬀerentiation. Further important developments have been the identiﬁcation of the tub gene as an insulin-signaling molecule expressed in the nervous system and the elucidation of the signaling pathways associated with leptin activation of its long form of receptor in the hypothalamus. Thus, the identity of all of the spontaneous single gene mutations that cause obesity is now known. While these models were a major focus of the previous review, this chapter will concentrate on new information that has been published in the interim period. Readers are referred to the original chapter (1) and other chapters in the present edition of the Handbook of Obesity for more detailed information on the single gene models and other nonrodent models of obesity.
Optical coherence tomography: A new strategy to image planarian regeneration (2014)

The planarian is widely used as a model for studying tissue regeneration. In this study, we used optical coherence tomography (OCT) for the real-time, high-resolution imaging of planarian tissue regeneration. Five planaria were sliced transversely to produce 5 head and 5 tail fragments. During a 2-week regeneration period, OCT images of the planaria were acquired to analyze the signal attenuation rates, intensity ratios, and image texture features (including contrast, correlation, homogeneity, energy, and entropy) to compare the primitive and regenerated tissues. In the head and tail fragments, the signal attenuation rates of the regenerated fragments decreased from -0.2 dB/μm to -0.05 dB/μm, between Day 1 and Day 6, and then increased to -0.2 dB/μm on Day 14. The intensity ratios decreased to approximately 0.8 on Day 6, and increased to between 0.8 and 0.9 on Day 14. The texture parameters of contrast, correlation, and homogeneity exhibited trends similar to the signal attenuation rates and intensity ratios during the planarian regeneration. The proposed OCT parameters might provide biological information regarding cell apoptosis and the formation of a mass of new cells during planarian regeneration. Therefore, OCT imaging is a potentially effective method for planarian studies.
Abstract 4080: Smad and NFAT pathways cooperate to regulate CD103 expression in human CD8 T lymphocytes and TCR-mediated epithelial tumor cell killing (2014)

Abstract The interaction of integrin αE(CD103)β7, often expressed on tumor-infiltrating lymphocytes (TIL), with epithelial cell marker E-cadherin on tumor cell surface plays a major role in antitumor cytotoxic T lymphocyte (CTL) responses. CD103 is encoded by ITGAE gene and is induced in CD8 T cells upon T-cell receptor (TCR) engagement and exposure to transforming growth factor (TGF)-β1, abundant within the tumor microenvironment. However, the transcriptional mechanisms underlying the cooperative role of these two signaling pathways in inducing CD103 expression in CD8 T cells remain unknown. Using a model system based on a CD8+/CD103- T-cell clone, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are required for CD103 induction on T lymphocytes activated with a combination of TGF-β1 and anti-CD3 monoclonal antibodies. We also identified the promotor and enhancer elements of human ITGAE gene, and showed that Smad2/3 and NFAT-1 are necessary for the activity of the ITGAE enhancer, and thus for CD103 expression. Overall, our results explain how TGF-β1 induces CD103 expression on locally activated CD8 T cells, thus contributing to antitumor CTL responses and malignant cell killing. Citation Format: Fathia Mami-Chouaib, M'barka Mokrani, Georges Bismuth. Smad and NFAT pathways cooperate to regulate CD103 expression in human CD8 T lymphocytes and TCR-mediated epithelial tumor cell killing. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4080. doi:10.1158/1538-7445.AM2014-4080
Force Visualization Mechanism using Moire Fringe for Endoscopic Surgical Instruments (2009)

This paper proposes a force visualization mechanism for endoscopic surgical instruments using Moire fringe. This mechanism can display fringes or characters that correspond to the magnitude of a force between the surgical instruments and internal organs without the use of electronic elements, such as amplifiers and strain gauges. It consists of an elastic element and two films printed with grating and can be built in the surgical instruments. The structure is simple, and its fabrication is inexpensive. We developed a forceps with the mechanism and experimentally verified that it can display the magnitude of the grasp force. We also verified that its display is visible through an endoscope at in vivo pig experiment.
Clinical and scientific impact of human papillomavirus on head and neck cancer (2014)

Head and neck cancer (HNC) arises from the skull base to the clavicles and is the fifth most common cancer in the world by incidence. Historically, in the developed world HNC was associated with tobacco use and alcohol consumption, and the combination of the two produced a synergistic increase in risk. However, beginning in 1983, investigators have found a significant and growing proportion of HNC patients with human papillomavirus-positive (HPV) tumors who neither drank nor used tobacco. Since that time, there has been increased interest in the molecular biology of HPV-positive HNC. Multiple studies now show that HPV has shifted the epidemiological landscape and prognosis of head and neck squamous cell carcinoma (HNSCC). These studies provide strong evidence for improved survival outcomes in patients with HPV-positive HNSCC compared to those with HPV-negative HNSCC. In many reports, HPV status is the strongest predictor of locoregional control, disease specific survival and overall survival. In response to these findings, there has been significant interest in the best management of HPV-positive disease. Discussions within major cooperative groups consider new trials designed to maintain the current strong survival outcomes while reducing the long-term treatment-related toxicities. This review will highlight the epidemiological, clinical and molecular discoveries surrounding HPV-related HNSCC over the recent decades and we conclude by suggesting how these findings may guide future treatment approaches.
Quantum metrology with entangled photons (2001)

Although most physics experiments are carried out with independent particles, it is the collective nature of entangled particles that reveals the most fascinating and unexpected aspects of the quantum world. It was Erwin Schrodinger who first said “entanglement is not one but rather the characteristic trait of quantum mechanics”. One curious aspect of the behavior of a pair of particles in an entangled state is that, though each individual particle exhibits an inherent uncertainty, the joint entity of an entangled pair can exhibit no such uncertainty. As an example, while the time of arrival of an individual particle may be totally random, an entangled pair must always arrive simultaneously. This property offers a unique tool for carrying out absolute measurements. Our goal here is to explore the myriad implications and significance of entanglement and to exploit it for the development of a new type of optical measurement—quantum optical metrology. The existence of unique non-classical correlations between twin photons generated in the nonlinear process of spontaneous parametric origins. The non-classical link between such twin quanta is not diminished by arbitrarily large separations between the twins, even when they lie outside the light cone. Twin states have been used with great effectiveness over the past two decades for carrying out definitive quantum experiments that lead to counterintuitive results; among these are those arising from the EinsteinPodolsky-Rosen (EPR) paradox such as various tests of Bell’s inequalities [1-12], as well as non-local dispersion cancellation, entangled-photon–induced transparency, and entangled-photon spectroscopy with monochromatic light. The availability of these twin beams has made it possible to conduct such experiments without having to resort to
Bioactive Bioceramics (2008)

Bioactive bioceramics as alternative to autografts and allografts include: bioactive glass, calcium carbonate (natural coral), calcium sulfate and calcium phosphates of biologic (derived from bovine bone, coral and marine algae) or synthetic origin. These bioceramics are available as granules or blocks (dense or porous), specially designed shapes (wedges, cylinders), cements or as coatings on orthopedic or dental implants. Properties of bone that are emulated by bioceramics include: interconnecting porosity, degradation and osteoconductivity. Osteoinductivity is introduced by mixing the bioceramics with osteogenic molecules (e.g., growth factors, demineralized bone matrix). Some calcium phosphate-based bioceramics were observed to have osteoinductive properties attributed to yet-to-be-defi ned critical geometry. Difference in composition and syntheses or processing methods affect the properties of the bioceramics. Applications of these bioceramics are described. The applications are limited to non-load bearing areas because of the poor mechanical strengths of these bioceramics. In addition to their application as bone graft substitutes or autograft extenders, some of these bioceramics are effi cient carriers for growth factors or drugs, and as scaffolds for tissue engineering.
Structure and coding properties of Bs1, a maize retrovirus-like transposon. (1989)

We have sequenced Bs1, an insertion element isolated from a null allele of the Adh1 locus encoding alcohol dehydrogenase in maize. The Bs1 element is 3203 base pairs (bp) in length, has 302-bp identical long terminal direct repeats (LTRs), and created a 5-bp flanking direct duplication of target Adh1 DNA upon insertion. The 5' LTR is followed by a canonical primer binding site with homology to the plant initiator methionyl-tRNA, and the 3' LTR is directly preceded by a polypurine stretch like that observed in retroviruses and retrotransposons. Bs1 encodes two overlapping open reading frames specifying peptides of 740 and 168 amino acids. The longer open reading frame specifies a peptide with amino acid homology to the protease and nucleic acid binding moiety of retroviruses and retrotransposons. The deduced amino acid sequence encoded by Bs1 lacks convincing homology to the polymerase (reverse transcriptase) encoded by retroposons, despite the fact that this polymerase-encoding domain is routinely the most conserved region of any such element. The sequence and relatively small size of Bs1 suggest that this element is a deleted retrotransposon that inserted into Adh1 with the aid of a reverse transcriptase function provided in trans. In vitro transcribed Bs1 complementary RNA was translated in vitro to produce both a protein of 81 kDa representing open reading frame 1 (ORF1) and one of the 95-kDa size predicted for the frame-shifted fusion of ORF1 and ORF2. As with many other retroposons, the efficiency of translational initiation at the AUG beginning ORF1 was not noticeably affected by the presence of one or more upstream, unproductive AUGs in the complementary RNA transcript.
Dix voies d'avenir pour neuf milliards d'humains (2012)

Des dÃ©fis gigantesques attendent l'humanitÃ©. Nous serons 9 milliards en 2045, c'est-Ã -dire qu'en 33 ans, 2 milliards d'individus vont s'ajouter aux 7 milliards existants. Il nous faudra gÃ©rer cette augmentation dans un monde en crise. Nos besoins en ressources et notre impact sur la biodiversitÃ© et l'environnement vont continuer de croÃ®tre.Ce livre propose des solutions pour permettre un bien-Ãªtre Ã tous de faÃ§on Ã©quitable et dÃ©mocratique, Ã condition de revoir notre rapport Ã l'Ã©conomie et au monde vivant. Cette dÃ©marche implique une rÃ©appropriation urgente du pouvoir citoyen sur le pouvoir Ã©conomique pour dÃ©terminer des choix de dÃ©veloppement qui remettent l'humain au centre des prÃ©occupations dans le monde naturel dont il dÃ©pend.
Acoustic Antennas for Biomedical and Industrial Ultrasonic Imaging (2011)

This chapter contains sections titled: Introduction Basic ultrasonic transducers Transducer arrays Piezoelectric material issues Modeling, design and characterization of ultrasonic antennas High frequency (HF) acoustic antennas for biomedical microscanning applications New acoustic antennas based on technology of capacitive micromachined ultrasonic transducers Conclusion Bibliography
Tellurium Containing Organic Metals (1985)

Abstract The electrical conductivity as a function of temperature is reported for single crystals of HMTTeF-TCNQ and HMTTeF-DMTCNQ. The crystal structure for one form of the DMTCNQ salt of HMTTeF is described and a procedure is outlined that could ultimately produce TMTTeF.
Toward safe close-proximity human-robot interaction with standard industrial robots (2014)

Allowing humans and robots to interact in close proximity to each other has great potential for increasing the effectiveness of human-robot teams across a large variety of domains. However, as we move toward enabling humans and robots to interact at ever-decreasing distances of separation, effective safety technologies must also be developed. While new, inherently human-safe robot designs have been established, millions of industrial robots are already deployed worldwide, which makes it attractive to develop technologies that can turn these standard industrial robots into human-safe platforms. In this work, we present a real-time safety system capable of allowing safe human-robot interaction at very low distances of separation, without the need for robot hardware modification or replacement. By leveraging known robot joint angle values and accurate measurements of human positioning in the workspace, we can achieve precise robot speed adjustment by utilizing real-time measurements of separation distance. This, in turn, allows for collision prevention in a manner comfortable for the human user.We demonstrate our system achieves latencies below 9.64 ms with 95% probability, 11.10 ms with 99% probability, and 14.08 ms with 99.99% probability, resulting in robust real-time performance.
Operational characteristics of the vibrating orifice aerosol generator (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOperational characteristics of the vibrating orifice aerosol generatorJames B. WeddingCite this: Environ. Sci. Technol. 1975, 9, 7, 673–674Publication Date (Print):July 1, 1975Publication History Published online1 May 2002Published inissue 1 July 1975https://pubs.acs.org/doi/10.1021/es60105a014https://doi.org/10.1021/es60105a014research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Clinical significance of CEA levels in lung cancer]. (1985)

Serum concentrations of CEA, Ferritin, beta 2-MG, TPA and IAP were measured in patients with lung cancer. Significant difference of positive rate between lung cancer and benign chest disease was observed only in CEA and TPA. CEA elevations occurred most frequently with stage IV and histologically with adenocarcinoma. Positive CEA levels (greater than or equal to 5 ng/ml) of pleural effusion were observed in 75% of all patients with lung cancer and increased to 94% in patients with positive cytology of effusion. There was not significant difference of bronchial washings CEA levels between lung cancer and benign chest disease. Furthermore, serial measurement of postoperative CEA levels had considerable value in monitoring the course of disease following resection.