gebhart/patrepeval huggingface dataset:
Design and Facile Synthesis of Neoglycolipids as Lactosylceramide Mimetics and Their Transformation into Glycoliposomes (2005)

Neoglycolipids composed of disaccharide glycoside and phospholipid were designed and prepared as mimetics of lactosylceramide. The lactosyl- and N-acetyllactosaminyl-phospholipids (Lac-DPPA and LacNAc-DPPA) were enzymatically synthesized from lactose and LacNAc respectively by cellulase-mediated condensation with 1,6-hexanediol, followed by conjugation of the resulting glycosides and dipalmitoylphosphatidyl choline (DPPC) mediated by Streptomyces phospholipase D. Alternatively, allyl beta-lactoside was ozonolyzed to give an aldehyde, which was condensed with dipalmytoyl phosphatidyl ethanolamine to afford a second type of glycolipid (Lac-DPPE). NMR spectroscopy indicated that the neoglycolipids behave differently in different solvent systems. X-ray diffraction clearly showed that multilamellar vesicles (MLVs) of Lac-DPPE and Lac-DPPA-MLV are in the bilayer gel phase at 20 degrees C, whereas those of Lac-DPPE-MLV were in the lamellar liquid-crystalline phase at 50 degrees C. Differential scanning calorimetry showed that Lac-DPPE-MLV had complex thermotropic behavior depending on the incubation conditions. After a long incubation at 10 degrees C, endothermic transitions are observed at 39.6, 42.3 degrees C, and 42.9 degrees C. These neoglycolipids have the ability to trap calcein, a chelating derivative of fluorescein, in MLVs and showed specific binding to lectin in plate assays using fluorescently labeled compounds.
De-Regulated MicroRNAs in Pediatric Cancer Stem Cells Target Pathways Involved in Cell Proliferation, Cell Cycle and Development (2013)

Our findings indicated that CSC associated DEmiRs and the putative pathways they regulate may have potential therapeutic applications in pediatric cancers.
Oxygen atom insertion into the benzylic carbon-hydrogen bond of (R)-(-)-2-phenylbutane by methyl(trifluoromethyl)dioxirane: an efficient and mild regio- and stereoselective synthesis of (S)-(-)-2-phenyl-2-butanol (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen atom insertion into the benzylic carbon-hydrogen bond of (R)-(-)-2-phenylbutane by methyl(trifluoromethyl)dioxirane: an efficient and mild regio- and stereoselective synthesis of (S)-(-)-2-phenyl-2-butanolWaldemar Adam, Gregorio Asensio, Ruggero Curci, Maria Elena Gonzalez-Nunez, and Rossella MelloCite this: J. Org. Chem. 1992, 57, 3, 953–955Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00029a030https://doi.org/10.1021/jo00029a030research-articleACS PublicationsRequest reuse permissionsArticle Views312Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Relationship of the Glenohurneral Joint Capsule to the Rotator Cuff (1990)

The glenohumeral joint capsules of 23 shoulders in which the rotator cuff was not torn were studied by gross dissection and histologic methods. The cuff tendons were resected, leaving the intact capsule attached to the bones. This dissection method provided a unique overview of the capsule in situ and allowed the areas of cuff tendon and muscle attachment to be mapped. The capsule was found to be a continuous cylinder between humerus and glenoid. On approximately one-third of the capsule (the portion adjacent to the humeral tuberosities), tight insertions of cuff tendons were noted. The superior segment between subscapularis and supraspinatus contained the coracohumeral ligament. This segment appeared to reinforce the cuff through a transversely oriented band similar to the glenohumeral ligaments.
Hydrides: Fundamentals and Applications (2016)

Both the Japanese and Hawaiian archipelagos are both completely devoid of petroleum resources.[...]
Eingebettete Sicherheit: State-of-the-art (2004)

Es wird vielfach angenommen, dass die nachste Revolution in der IT-Landschaft durch die Vernetzung von einge- betteten Systemen erfolgen wird. In solche pervasiven Computeranwendungen wird IT-Sicherheit eine extrem wichtige Rolle spielen. Obwohl es starke Indikatoren gibt, dass die eingebettete Sicherheit von grosser Bedeutung sein wird, ist sie als eigenstandiges Gebiet bisher kaum betrachtet worden. Ziel des vorliegenden Beitrags ist es, verschiedene Aspekt der eingebetteten Sicherheit in einer Gesamtdarstellung naher zu beleuchten. Insbesondere werden die speziflschen Probleme der eingebetteten Sicherheit naher betrachtet. Anhand von Fallbeispielen im Automobil und in ad-hoc Netzen werden zukunftige Probleme und Moglichkeiten von IT-Sicherheit in eingebet- teten Anwendungen verdeutlicht. Zwei wichtige Realisierungsaspekte von sicheren eingebetteten Systemen in der Praxis, namlich e-ziente asymmetrische Verfahren in rechenbeschrankten Umgebungen und Seitenkanalattacken, werden ebenfalls diskutiert. 1 Einleitung In den letzten Jahrzehnten hat das Internet zunehmend Computer vernetzt und hat mit Anwendungen wie dem World Wide Web und Email den Informations∞uss und die Kommunikation in vielen Lebensbere- ichen dramatisch beein∞usst. Geschaftsablaufe, private Kommunikation, Interaktion zwischen Burgern undVerwaltung u.v.a.m. haben zum Teil revolutionare Veranderungen erfahren. Hierdurch sind viele neue Sicherheitsprobleme, beispielhaft seien hier Anonymitat, Identitatsdiebstahl, Computer- viren, Schutz digitaler Inhalte etc. genannt, entstanden. Dies hat zu sehr aktiven wissenschaftlichen und kommerziellen Communities auf dem Gebiet der IT-Sicherheit gefuhrt, die sich inzwischen in viele Unterdisziplinen einteilen lassen, z.B. theoretische und angewandte Kryptographie, Netzsicherheit, Com- putersicherheit, Digital Rights Management, Intrusion Detection. Obwohl es sicherlich noch eine Reihe ofiener Fragen, insbesondere bezuglich der praktischen Umsetzung von IT-Sicherheitslosungen gibt, sind viele Sicherheitsprobleme prinzipiell gelost und es stehen zahlreiche Produkte hierfur zur Verfugung. Eine hoch interessante Fragestellung ist nun, welche neuen Anwendungsfelder fur die zukunftige IT- Sicherheit von Bedeutung sein werden. Wir glauben, dass eine Antwort hierauf der ebenso umfang- wie fassettenreiche Bereich der Sicherheit fur eingebettete Systeme, im folgenden EMSEC genannt, ist. Zunachst zur Deflnition: Man bezeichnet ein Gerat als ein eingebettetes System, wenn die folgenden Eigenschaften vorliegen: † Das Gerat ist im wesentlich fur eine Anwendung konzipiert (z.B. Waschmaschine, Mobiltelefon, Uhr, Automobil).
Synthesis of N‐(2, 5‐[2‐<sup>13</sup>C]dimethyl‐1H‐pyrrol‐1‐YL)‐6‐(4‐morpholinyl)‐3‐Pyridazinamine hydrochloride (1985)

Abstract N‐(2, 5‐[2‐ 13 C]dimethyl‐1H‐pyrrol‐1‐yl)‐6‐(4‐morpholinyl)‐3‐pyridazinamine hydrochloride ([2‐ 13 C]methyl MDL‐899), a new antihypertensive agent, was synthesized for metabolic studies, in five steps via 2, 5‐[1‐ 13 C]hexanedione, and characterized by 1 H‐ and 13 C‐NMR, IR, and MS.
POROKERATOSIS MIBELLI (1943)

Mibelli<sup>1</sup>reported the first case of porokeratosis in 1893. Moncorps<sup>2</sup>recorded 95 cases which had appeared in the literature up to 1931. From 1931 to 1941 we have found 24 reports dealing with 37 affected persons. Geographic location or race does not seem to play an important role. Cases have been observed not only in Italy but in China, Japan, France, Germany, England, Poland, Russia, Argentina, Switzerland and the United States. Lain<sup>3</sup>in 1928 stated that among the 70 cases which he gathered from the literature, including 3 of his own, 20 were from this country. We have found 7 cases reported in the United States in the past decade. The patients whose cases were reported by Ambler and Stout<sup>4</sup>and by Johnson<sup>5</sup>were both Negroes. <h3>CLINICAL AND HISTOLOGIC CHARACTERISTICS</h3> Because of the repeated clinical and histologic descriptions of porokeratosis Mibelli in the literature, we
ChemInform Abstract: HETEROGENEOUS CODIMERIZATION OF ACETYLENES AND ALLYL HALIDES WITH POLYMER‐SUPPORTED PALLADIUM(II) CHLORIDE CATALYST (1976)

Abstract Phenylacetylen und Allylchlorid bilden bei 20°C die Codimeren (III) und (IV) in heterogener Phase.
Purification and properties of leucyl-tRNA-synthetase from the mammalian tissues (1985)

Описан метод выделения лейцил-тРНК-синтетазы (лейРС) из печени кролика и миокарда свиньи. В отличие от фермента печени лейРС миокарда при хроматографии на оксиапатите разделяется на два компонента (E₁ и Е₂). Молекулярные массы ферментов, установленные методом электрофореза в полиакриламидном геле, составляют 185000 и 158000 для лейРС печени кролика и Е₂ миокарда свиньи соответственно. Установлено, что Е₂ содержит аминоацил-тРНК-синтетазные активности других аминокислотных специфичностей и представляет собой комплекс ферментов с молекулярной массой приблизительно 800000. Изучены оптимальные условия реакции аминоацилирования, катализируемой лейРС печени и миокарда, и определены кинетические параметры реакции.
Speciation, Characterization, and Mobility of As, Se, and Hg in Flue Gas Desulphurization Residues (2008)

Flue gas from coal combustion contains significant amounts of volatile toxic trace elements such as arsenic (As), selenium (Se), and mercury (Hg). The capture of these elements in the flue gas desulphurization (FGD) scrubber unit has resulted in generation of a metal-laden residue. With increasing reuse of the FGD residues in beneficial applications, it is important to determine metal speciation and mobilityto understand the environmental impact of its reuse. In this paper, we report the solid phase speciation of As, Se, and Hg in FGD residues using X-ray absorption spectroscopy (XAS), X-ray fluorescence spectroscopy (XRF), and sequential chemical extraction (SCE) techniques. The SCE results combined with XRF data indicated a strong possibility of As association with iron oxides, whereas Se was distributed among all geochemical phases. Hg appeared to be mainly distributed in the strong-complexed phase. XRF images also suggested a strong association of Hg with Fe oxide materials within FGD residues. XAS analysis indicated that As existed in its oxidized state (As(V)), whereas Se and Hg was observed in primarily reduced states as selenite (Se(IV)) and Hg(I), respectively. The results from the SCE and variable pH leaching tests indicated that the labile fractions of As, Se, and Hg were fairly low and thus suggestive of their stability in the FGD residues. However, the presence of a fine fraction enriched in metal content in the FGD residue suggested that size fractionation is important in assessing the environmental risks associated with their reuse.
[3‐Bromo‐2‐lithio‐1‐phenylsulfonylbenzofuran Diisopropyl Ether]<sub>2</sub> and 3‐Fluoro‐2‐lithio‐1‐phenyl‐sulfonylbenzene · Pentamethyldiethylenetriamine : Crystal Structures of Compounds with Lithium and Halogen on Neighboring Carbon Atoms (1991)

The crystal structures and reactivities in solution correlate for the title compounds. The β-elimination of lithium and halide to the corresponding (hetero)aryne does not occur in the case of bromobenzofuran 1, in which the CBr bond length is that same as in its nonlithiated counterpart; LiF elimination does occur in compound 2, whose CF bond is lengthened in comparison to the neutral fluoroarene. This implies that the elimination is structurally predetermined. PMDETA = N, N, N′, N″, N″-pentamethyldiethylenetriamine.
Dynamic dead-instruction detection and elimination (2002)

We observe a non-negligible fraction--3 to 16% in our benchmarks--of dynamically dead instructions, dynamic instruction instances that generate unused results. The majority of these instructions arise from static instructions that also produce useful results. We find that compiler optimization (specifically instruction scheduling) creates a significant portion of these partially dead static instructions. We show that most of the dynamically instructions arise from a small set of static instructions that produce dead values most of the time.We leverage this locality by proposing a dead instruction predictor and presenting a scheme to avoid the execution of predicted-dead instructions. Our predictor achieves an accuracy of 93% while identifying over 91% of the dead instructions using less than 5 KB of state. We achieve such high accuracies by leveraging future control flow information (i.e., branch predictions) to distinguish between useless and useful instances of the same static instruction.We then present a mechanism to avoid the register allocation, instruction scheduling, and execution of predicted dead instructions. We measure reductions in resource utilization averaging over 5% and sometimes exceeding 10%, covering physical register management (allocation and freeing), register file read and write traffic, and data cache accesses. Performance improves by an average of 3.6% on an architecture exhibiting resource contention. Additionally, our scheme frees future compilers from the need to consider the costs of dead instructions, enabling more aggressive code motion and optimization. Simultaneously, it mitigates the need for good path profiling information in making inter-block code motion decisions.
A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3CLudvig Eriksson, Sharon Guy, Patrick Perlmutter, and Richard LewisView Author Information Department of Chemistry, Monash University, Clayton, Victoria, 3168, Australia Centre for Drug Design and Delivery, University of Queensland, Australia Cite this: J. Org. Chem. 1999, 64, 22, 8396–8398Publication Date (Web):October 29, 1999Publication History Received4 March 1999Published online29 October 1999Published inissue 1 October 1999https://pubs.acs.org/doi/10.1021/jo990389chttps://doi.org/10.1021/jo990389cbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views198Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Assays,Chemical synthesis,Ethers,Immunoassays,Toxins Get e-Alerts
Automated detection and quantification of venous beading using Fourier analysis. (1992)

Venous beading associated with diabetic retinopathy is currently assessed by means of subjective comparison to standard photographs from the modified Airlie House classification scheme. We describe a computerized grading scheme for venous beading. The algorithm, based on Fourier analysis of vessel width measurements, generates a venous beading index (VBI) for digitized colour fundus photographs. Colour photographs of local vessel segments about 1200 microns in length were evaluated by experienced graders. A comparison between the VBI and subjective grading showed good agreement. The mean VBI values across the four levels of clinical grading were significantly different (p = 0.000). Multiple comparison testing indicated that the VBI was able to significantly differentiate between all four categories except the "questionable" (grade 1) category (p < 0.05). We also found that progression of venous beading can be followed with the VBI. The results indicate that further development of automated grading of venous beading is warranted.
ChemInform Abstract: Carbon Networks Based on Dehydrobenzoannulenes. Part 3. Synthesis of Graphyne Substructures. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in <i>Drosophila microtubule star (mts)</i> embryos (1996)

A Drosophila strain, carrying a P[lacW] element in the promoter of the protein phosphatase 2A (PP2A) catalytic subunit gene at chromosomal location 28D, has been identified using plasmid rescue of the P element and adjoining genomic DNA in Escherichia coli. Reversion mutagenesis was employed to demonstrate that the observed phenotype of the Drosophila strain was due to a single P[lacW] element insertion at 28D and to create three deficiency strains at this locus. Drosophila heterozygous for P[lacW]28D have reduced levels of PP2A mRNA and reduced PP2A catalytic activity against four different substrates compared to wild type, while homozygotes are deduced to have approximately 20% of wild-type PP2A activity. P[lacW]28D homozygotes, termed microtubule star (mts), die in embryo-genesis around the time of cellularisation, exhibiting over-condensed chromatin and a block in mitosis between prophase and the initiation of anaphase. Multiple centrosomes are visible in cellularised embryos, suggesting that PP2A may play a role in coupling the nuclear and centrosome cycles. When embryos arrest just prior to cellularisation, disorganised elongated arrays of microtubules radiate from centrosomes in all directions, but they are rarely associated with any DNA, suggesting that PP2A is required for the attachment of microtubules to chromosomal DNA at the kinetochore.
Plasma lipids and their fatty acid composition in multiple sclerosis (1988)

We report an extensive study of the plasma lipid profile and fatty acid composition in 61 multiple sclerosis (MS) patients compared with 61 normal subjects. The main abnormality in the MS was a reduction in the proportion of linoleic and arachidonic acids mostly evident in the HDL and in the cholesteryl esters fraction, with a compensatory increase in saturated acids. The fatty acid abnormalities correlated with the duration of the disease and the degree of disability. Thus, in the MS patients studied there was a deficiency in essential fatty acids, although this metabolic abnormality does not seem specific to MS.
Characterization of a Water-soluble Polysaccharide Fraction with Immunopotentiating Activity from<i>Bifidobacterium adolescentis</i>M101–4 (1997)

The soluble and insoluble fractions obtained after sonication and centrifugation of Bifidobacterium adolescentis M101-4 cells were examined, and both of these fractions exhibited mitogenic activity in an assay of murine splenocytes and Peyer's patch cells in vitro. The soluble fraction was further treated by a 6-step procedure involving proteinase K-treatment, ultrafiltration with a 50-kDa cut-off molecular-sieving membrane, anion-exchange chromatography, dialysis, ultrafiltration through a 6-kDa cut-off membrane filter, and gel-filtration to yield a soluble high molecular weight fraction (SHF) which was effective for stimulating the proliferation of murine splenocytes. Almost three quarters of this fraction by weight was found to consist of carbohydrates containing glucose and galactose as major constituents, and the average molecular weight was estimated to be between 60,000 and 2,460,000, with the main peak at 1,550,000 Da, by the retention time of gel permeation chromatography. A structural analysis by 1H- and 13C-nuclear magnetic resonance and methylation indicated that SHF contained polysaccharides consisting of -4Galp1-, -4Glcp1-, and -6Glcp1- as the major residues, and Galf1- and -6Galf1- as the minor residues. Immunopotentiating SHF was found to contain galactofuranosyl residues as characteristic constituents which had not been previously detected in other soluble fractions from Gram-positive bacteria.