gebhart/patrepeval huggingface dataset:
ChemInform Abstract: A Concise Microwave‐Assisted Synthesis of 2‐Aminoimidazole Marine Sponge Alkaloids of the Isonaamines Series. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Patterns of heat shock protein (HSP70) expression and Kupffer cell activity following thermal ablation of liver and colorectal liver metastases (2005)

The time course and extent of thermal ablative injury differs in liver compared to tumour tissue. This may be influenced by differences in the expression of heat shock proteins (HSP) and the response of Kupffer cells to thermal injury. This study determines the expression and response of HSP70 and Kupffer cells to thermal ablative injury in a Murine model of colorectal liver metastases. Thermal ablation by laser (Nd-YAG wavelength 1064 nm) was induced in liver and colorectal cancer liver metastases in CBA strain mice. Laser energy was applied at 2 W for 50 s and produced incomplete tumour ablation. Established tissue injury was assessed in separate groups of animals at time points ranging from 12 h to 21 days following therapy. HSP70 and Kupffer cell expression at the margins of coagulated tissue was determined by immunohistochemical staining for HSP70 and F4/80 antigens, respectively. HSP70 was faintly expressed in the cytoplasm of all tumour cells, with distinct clusters exhibiting intense cytoplasmic and nuclear HSP70 staining (130+/-19 cells mm-2). Comparatively, HSP70 expression was uncommon in untreated control liver specimens (2+/-2 cells mm-2, p<0.001). Thermal ablation increased expression of HSP70 at coagulated tissue margins. The peak response in tumours occurred at 2 days post-ablation and was significantly greater than the peak response in liver, occurring at 12 h (809+/-80 cells mm-2 vs. 454+/-52 cells mm-2, p<0.001). HSP70 expression remained significantly elevated for 7 days following therapy in tumour tissue, compared to 3 days in liver. Kupffer cell numbers in untreated control tumours were significantly lower than in untreated control livers (285+/-23 cells mm-2 vs. 451+/-30 cells mm-2, p<0.001). Following thermal ablation, there was an initial decrease in Kupffer cell numbers at the margin of coagulation with subsequent persistent increases thereafter. In liver tissue, the peak Kupffer cell response occurred at 5 days post-therapy and was significantly greater than the peak response in tumour tissue 3 days post-thermal ablation (1074+/-34 cells mm-2 vs. 860+/-53 cells mm-2, p=0.007). Thermal ablation produces a greater and more prolonged HSP70 response in colorectal liver metastases than in liver tissue. It also induces persistent increases in Kupffer cell activity in liver and tumour tissue.
Revisiting Self-Selection Biases in E-Word-of-Mouth: An Integrated Model and Bayesian Estimation of Multivariate Review Behaviors (2011)

This paper studies the consumer self-selection bias in the e-word-of-mouth (eWOM) systems, e.g. consumer review websites. Under Bayesian framework, this study extends our understanding of this bias and discovers two new sources through developing a system of structural models of consumer review behaviors tested by a large data set. Our model and results provide evidences that the timing and content of a review introduce significant amount of bias into ratings in a simultaneous fashion. Specifically, we find that after controlling for various exogenous effects the two sources of bias persist: a subsequent rating is positively associated with the time interval between two consecutive reviews by the same consumer, and is negatively associated with the length of a review. Clearly, our findings confirm that modern eWOM systems have notable flaws despite of their mechanical advantages. We further discuss the possible mechanisms as well as the economic impact underlying these findings.
VII. CALCIUM ACCUMULATION IN SUBCELLULAR PARTICLES IN CONGESTIVE HEART FAILURE (1971)

A B S T R A C T The ability of heavy microsomes and mitochondria, isolated from the control and failing hearts of genetically dystrophic hamsters (BIO 14.6 strain), to accumulate was examined. The rate and extent of energy-linked binding (in the absence of oxalate) by the heavy microsomes of the failing heart were markedly depressed. The uptake (in the presence of 5 mm oxalate) by the heavy microsomes of the failing heart was similar to that of the control heart. On the other hand, both the rate and extent of energylinked binding (in the absence of Pi and succinate) and uptake (in the presence of 4 mm Pi and 5 mm succinate) by mitochondria were greatly reduced in the failing heart in comparison to the control. No difference in the total adenosine triphosphatase activities (Ca++-Mg'+ stimulated) of heavy microsomes or mitochondria was observed between the control and failing hearts. These results indicate an abnormality of subcellular membranes of the failing heart to bind and support the growing conviction concerning the defective calcium pump as a molecular abnormality associated with a moderate degree of congestive heart failure.
Flavanones and Chromones from <i>Salicornia herbacea</i> Mitigate Septic Lethality via Restoration of Vascular Barrier Integrity (2015)

Salicornia herbacea is an annual halophytic glasswort that has been employed as a culinary vegetable, salad, and traditional medicinal resource. Chemical investigation of the aerial parts of S. herbacea led to the isolation of two new (1, 2) and known (3) flavanones as well as a new nature-derived (4) and two known chromone derivatives (5, 6). These purified compounds were evaluated for their suppressive potentials against the release of high-mobility group box 1 protein (HMGB1), which has captured attention as a viable target for alleviating serious septic manifestations or septicemia. The phenolic compounds improved the survival rates of cecal ligation and puncture operation (CLP) in murine models, simulating severe septic shock and its related complications, to 40-60%. These results collectively validate that flavanone- and chromone-based secondary metabolites may serve as prospective prodrugs or food additives that may be commercialized for the control of septic complications and lethality.
Asymmetric current-voltage characteristics in type-II superconductors (1994)

We report asymmetric current-voltage characteristics in superconducting films in a parallel magnetic field. The critical current, ${\mathit{I}}_{\mathit{c}}$, is found to differ by as much as 30% for negative and positive currents, and beyond ${\mathit{I}}_{\mathit{c}}$, the magnitude of the voltage is also different for positive and negative currents, \ensuremath{\Vert}V(+I)\ensuremath{\Vert}\ensuremath{\ne}\ensuremath{\Vert}V(-I)\ensuremath{\Vert}. The critical current difference \ensuremath{\Vert}${\mathit{I}}_{\mathit{c}+}$\ensuremath{\Vert}-\ensuremath{\Vert}${\mathit{I}}_{\mathit{c}\mathrm{\ensuremath{-}}}$\ensuremath{\Vert} has complicated behavior, changing sign as temperature and magnetic field are varied. We propose a model based on the Bean-Livingston surface barrier and inhomogeneous bulk pinning that accounts for all observed behavior.
<i>In Vivo</i> Replication-Deficient Adenovirus Vector-Mediated Transduction of the Cytosine Deaminase Gene Sensitizes Glioma Cells to 5-Fluorocytosine (1996)

Viral vector-mediated transfer of chemosensitization genes represents a promising new approach to the treatment of cancer. Previous reports have demonstrated that transfection of the bacterial cytosine deaminase (cd) gene into mammalian cells can sensitize them to the otherwise nontoxic nucleoside, 5-fluorocytosine (5-FC). We now report that a replication-deficient adenovirus vector that transduces the cd gene (Ad.CMV-cd) highly sensitizes 9L gliosarcoma cells to 5-FC, and that gene transduction is associated with a potent bystander effect that is not dependent on direct cell-to-cell contact. Stereotactic injection of Ad.CMV-cd into established rat gliomas, followed by systemic administration of 5-FC in vivo, results in prolongation of survival.
Recurrent Risk of Posterior Communicating Artery-preserving Coil Embolization for Internal Carotid Artery-Posterior Communicating Artery Aneurysm (2019)

Purpose: The aim of the present study was to assess the recurrence and retreatment rate after coil embolization of unruptured internal carotid artery-posterior communicating artery aneurysms (IC‑PC AN) classiﬁed according to the development of the posterior communicating artery (Pcom A) and to determine the risk factor of recurrence.
Issues of thrombosis and hemorrhagic events in patients with cancer. (1999)

It is clear that patients with malignancy, particularly adenocarcinomas, have an increased propensity to thrombosis. It also appears that patients with malignancy and thrombosis are relatively refractory to warfarin therapy and some may not respond ideally to heparin preparations. Occult malignancy in patients with unexplained thrombosis is of concern; however, the incidence varies with the age of the patient approaching 10% in those over 50 years of age. The extent of the evaluation for an underlying occult malignancy should be dictated by clinical judgment. Recurrent unexplained DVT, resistance to warfarin, and thrombosis of unusual sites are the major clues to significantly enhance the suspicion of an occult malignancy. In general, patients with thrombosis and malignancy need not be evaluated for hereditary or acquired hemostasis defects; finding one of these defects is both unlikely and will probably not alter antithrombotic therapy. Hemorrhage in cancer patients is usually due to thrombocytopenia related to chemotherapy (particularly solid tumors) or bone marrow failure (usually leukemias), or disseminated intravascular coagulation (DIC). DIC is usually seen in M-3 and M-4 leukemia or in septic patients with solid tumors. Finally, catheter thrombosis is a common problem in patients with cancer and can be significantly decreased with the routine use of low-dose warfarin therapy.
Anti-idiotypic B cells are required for the induction of suppressor T cells. (1986)

A nylon wool-adherent, B cell-enriched population is required during the in vitro induction of third order effector suppressor T cells (Ts3). This B cell population expresses IgM and IgD and is devoid of conventional T cell markers such as Thy-1, L3T4, and Lyt-1. Treatment of the B cell population with anti-NP antibodies expressing the NPb idiotype and complement specifically eliminated the ability to generate Ts cell activity, suggesting that the critical B cells expressed anti-idiotypic receptors. To independently verify the role of anti-idiotypic B cells in the generation of Ts cells, B cells were panned on antibody-coated plates. The results demonstrated that only NPb idiotype-binding B cells could induce effector suppressor cells from naive T cell populations. The combined data demonstrate the role of Ig network interactions in the generation of Ts cells.
Novel Synthesized Source for Microwave Measurement System (1991)

This paper aims to illustrate how the source forming part of a modern microwave measurement system can be significantly simplified and improved if it is tailored to a specific measurement task. By first considering the major requirements of such a source namely speed, accuracy, portability and cost, the design of a traditional microwave synthesizer is contrasted with that of a new architecture specifically designed for use in a modern swept measurement system.
Effect of catalyst onin situ silica reinforcement of styrene–butadiene rubber vulcanizate by the sol–gel reaction of tetraethoxysilane (1997)

In situ silica reinforcement of styrene–butadiene rubber (SBR) vulcanizate has been achieved by the sol–gel reaction of tetraethoxysilane (TEOS) using n-butylamine as a catalyst. SBR was vulcanized with sulfur and soaked in TEOS and in an aqueous solution of the catalyst. When hydrochloric acid was used as a catalyst for the sol–gel reaction, silica particles were not introduced into the SBR matrix in this study. The increase of the dynamic modulus and tensile strength at break was considered to be due to the interaction between the rubber and the in situ silica filler in the SBR vulcanizate.
Towards Understanding End-User Lighting Preferences in Office Spaces by Using Immersive Virtual Environments (2015)

Buildings and their systems are primarily designed based on several assumptions about end-users’ requirements and needs, which in many cases are incomplete and result in inefficiencies during operation phases of buildings. With advancements in fields of augmented and virtual reality, designers and engineers have now the opportunity to collect information about end-users’ requirements, preferences, and behaviors for more informed decision-making during the design phase. These approaches allow for buildings to be designed around the users, with the goal that the design will result in reduction of energy consumption and improved building operations. The authors examine the effect of design features on occupants’ preferences and performance within immersive virtual environments (IVEs). Specifically, this paper presents an approach to understand end-users’ lighting preferences and collect end-user performance data through the use of IVEs.
Easily Identifiable Discourse Relations (2008)

We present a corpus study of local discourse relations based on the Penn Discourse Tree Bank, a large manually annotated corpus of explicitly or implicitly realized relations. We show that while there is a large degree of ambiguity in temporal explicit discourse connectives, overall connectives are mostly unambiguous and allow high-accuracy prediction of discourse relation type. We achieve 93.09 % accuracy in classifying the explicit relations and 74.74 % accuracy overall. In addition, we show that some pairs of relations occur together in text more often than expected by chance. This finding suggests that global sequence classification of the relations in text can lead to better results, especially for implicit relations. 1
Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier (2012)

The brain is in many ways an immunologically and pharmacologically privileged site. The blood-brain barrier (BBB) of the cerebrovascular endothelium and its participation in the complex structure of the neurovascular unit (NVU) restrict access of immune cells and immune mediators to the central nervous system (CNS). In pathologic conditions, very well-organized immunologic responses can develop within the CNS, raising important questions about the real nature and the intrinsic and extrinsic regulation of this immune privilege. We assess the interactions of immune cells and immune mediators with the BBB and NVU in neurologic disease, cerebrovascular disease, and intracerebral tumors. The goals of this review are to outline key scientific advances and the status of the science central to both the neuroinflammation and CNS barriers fields, and highlight the opportunities and priorities in advancing brain barriers research in the context of the larger immunology and neuroscience disciplines. This review article was developed from reports presented at the 2011 Annual Blood-Brain Barrier Consortium Meeting.
Elastic and Inelastic Light Scattering from Distilling Microdroplets for Thermodynamic Studies (1996)

The evaporation rates of single-component droplets and the related thermodynamics of binary component droplets consisting of 1-iodododecane and 1-bromotetradecane have been explored using elastic and inelastic (Raman) light-scattering to determine the droplet size and chemical composition as diffusion-controlled evaporation proceeded. Single droplets were levitated electrodynamically in a chamber and exposed to a vapor-free nitrogen gas stream. Elastic scattering data for the single components, obtained at the same temperature, were used to determine the optical parameters and transport process parameters needed to interpret binary droplet Raman data for mixtures of the halogenated hydrocarbons. Evaporation rate theory coupled with a UNIFAC thermodynamic model for activity coefficients was shown to agree very well with experimental data collected from binary droplets. Results indicate that Raman intensity ratios associated with the C−I and C−Br bonds can be used to follow changes in composition quantitatively, but for greater accuracy more detailed analysis of the effects of morphology-dependent resonances on the Raman effect is needed.
Optical force mapping of plasmonic modes generated by a nanoantenna (2011)

We present experimental spatial mapping of optical force generated by the plasmonic mode confinement of a nanoantenna at 1550 nm. Maxwell's stress tensor method is used to simulate the force map and it agrees well with the experimental data.
Ion Transport and Thermomechanical Properties of SrFe(Al)O[sub 3−δ]–SrAl[sub 2]O[sub 4] Composite Membranes (2006)

Moderate additions of monoclinic to perovskite-type mixed conductors improve the sinterability and thermomechanical properties, including the thermal shock resistance, Vickers hardness, and fracture toughness, and decrease thermal expansion. The iron solubility in , a mixed ionic and n-type electronic conductor with insulating properties, is lower than 5%. The total conductivity of ceramics in air varies in the range at . The transport properties and phase stability of dual-phase composite membranes, where the partial dissolution of strontium aluminate in the ferrite phase leads to formation of A-site-deficient , are determined by the perovskite component. The total conductivity and Seebeck coefficient oxygen partial pressure dependencies exhibit general trends typical for -based solid solutions. Although the conductivity and oxygen permeability of composites decrease with increasing , the permeation fluxes through ceramics are comparable to those through single-phase . Under high gradients such as air/, the oxygen transport is limited by surface-related processes, enabling stable operation of membranes. This composition was selected for fabrication of tubular membranes by the cold isostatic pressing. Surface modification of in order to enhance the exchange kinetics was found inappropriate from a stability point of view.
Temporal Trends and Factors Associated with Systemic Therapy after Cytoreductive Nephrectomy: An Analysis of the National Cancer Database (2014)

Systemic therapy in patients undergoing cytoreductive nephrectomy has increased with time, coinciding with the introduction of targeted therapies. Nevertheless, still less than half of such patients receive systemic treatment. While the etiology of the lack of treatment is likely multifactorial, the potential health policy implications of disparities in care warrant further investigation.
<b>Identification of Atrial Fibrillation Episodes in Ambulatory Electrocardiographic Recordings:</b> Validation of a Method for Obtaining Labeled R‐R Interval Files (1995)

Current systems for analyzing ambulatory electrocardiograms (ECGs) are unable to distinguish precisely between sinus rhythm and atrial fibrillation (AF) episodes, and are unable to produce RR interval listings that distinguish AF from sinus rhythm on a beat-to-beat basis. We describe a method for obtaining such a computerized listing ("Composite Rhythm" file) from ambulatory recordings containing episodes of AF. The file lists the rhythm of each beat, its real time, and the QRS complex morphology. A visual inspection is made of a full printout of the recording to identify the precise time of onset and termination of each episode of AF. These times are entered into a computer and identified with the corresponding beats on a conventional RR interval file generated by Holter analysis. The method was validated using 1-hour segments from 20 ambulatory ECGs containing 145 episodes of AF. These were visually identified by four independent observers with a mean sensitivity of 99.1%. The first beat of AF was identified concordantly in 96% of episodes, with a discrepancy of < or = 3 beats in the other episodes. The times of 200 selected QRS complexes were then entered into the computer by each observer; 91.1% of these complexes were identified exactly and 100% were identified to within one beat. The Composite Rhythm files have several potential applications for testing AF detection algorithms and studying the mode of onset of AF.
Treatment of rice in Sake brewing. Part II. Sake brewing using rice koji made from powdered rice. (1986)

(1) 粉砕白米を用いて行う製麹では,引き込み時の水分を粒状の場合より少し高目の35～36%ぐらいにする必要がある. (2) 粉砕白米で作った麹は酵素力価が高くなり,麹歩合をその分だけ少なくすることができる. (3) 生の白米の場合でも粒状麹に比較して粉砕状麹のほうが菌体量ならびに各酵素力価ともに高い数値を示した. (4) 粉砕白米を用いて行う製麹では,麹の菌体量,各酵素活性の米の品種間における差がなくなるので,硬い米でも良質の麹が作りえた. (5) 粉砕状麹は粒状麹に比較して膠中でよく溶けた. (6) 麹を粉砕白米で作ることにより,粕歩合が約4%低くなり,さらに掛米,麹とも粉砕状にし,膠初期の汲水歩合等を勘案して醗酵させれば,粕歩合が約10%低くなって酒化率も43l/t前後向上するということがわかった.
Development and validation of an enzyme-linked immunosorbent assay for feline trypsin-like immunoreactivity (2000)

Results suggest that an ELISA can be used to measure serum fTLI in cats. The ELISA was sufficiently sensitive, linear, accurate, precise, and reproducible for clinical use.
Hilbert Transform in Fourier Spectroscopy (1966)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Hajime Sakai and George A. Vanasse, "Hilbert Transform in Fourier Spectroscopy," J. Opt. Soc. Am. 56, 131-132 (1966) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Molecular analysis of the recA gene and SOS box of the purple non-sulfur bacterium Rhodopseudomonas palustris no. 7 (1999)

The recA gene of the purple non-sulfur bacterium Rhodopseudomonas palustris no. 7 was isolated by a PCR-based method and sequenced. The complete nucleotide sequence consists of 1089 bp encoding a polypeptide of 363 amino acids which is most closely related to the RecA proteins from species of Rhizobiaceae and Rhodospirillaceae. A recA-deficient strain of R. palustris no. 7 was obtained by gene replacement. As expected, this strain exhibited increased sensitivity to DNA-damaging agents. Transcriptional fusions of the recA promoter region to lacZ confirmed that the R. palustris no. 7 recA gene is inducible by DNA damage. Primer extension analysis of recA mRNA located the recA gene transcriptional start. A sequential deletion of the fusion plasmid was used to delimit the promoter region of the recA gene. A gel mobility shift assay demonstrated that a DNA-protein complex is formed at this promoter region. This DNA-protein complex was not formed when protein extracts from cells treated with DNA-damaging agents were used, indicating that the binding protein is a repressor. Comparison of the minimal R. palustris no. 7 recA promoter region with the recA promoter sequences from other alpha-Proteobacteria revealed the presence of the conserved sequence GAACA-N6-G(A/T)AC. Site-directed mutations that changed this consensus sequence abolished the DNA-damage-mediated expression of the R. palustris recA gene, confirming that this sequence is the SOS box of R. palustris and probably plays the same role in other alpha-Proteobacteria.