gebhart/patrepeval huggingface dataset:
Resistance to Antibiotics By Gonococci (1972)

<h3>To the Editor.—</h3> Referring to the LETTERS of Lancaster and Roberts (<b>217</b>:1106, 1971), it should be remembered that high-dose antibiotic treatment of patients with known gonorrhea will not in itself alter the development of resistance to the antibiotic by the gonococcus. The real problem comes in the treatment of unknown asymptomatic women carriers with low doses of antibiotics for other infections. It is in these women that the gonococcus has the opportunity to develop resistance to the antibiotic administered. One solution to this quandary is the routine culturing for the gonococcus of all women about to undergo antibiotic treatment of any infection, which is less than practical. An alternative is to reserve an antibiotic exclusively for the treatment of gonorrhea and not use it in the treatment of other infections.
The Cumacean Dimorphostylis elegans Gamô, 1960 (Crustacea), D. bathyelegans n. sp. and D. brevicarpus n. sp. from Japan (2011)

Akiyama, Tadashi (2011): The Cumacean Dimorphostylis elegans Gamô, 1960 (Crustacea), D. bathyelegans n. sp. and D. brevicarpus n. sp. from Japan. Zootaxa 2994: 45-59, DOI: 10.5281/zenodo.200637
Southern Hemisphere Measurement of the Anisotropy in the Cosmic Microwave Background Radiation - eScholarship (1979)

LBL-9282£, Preprint ' Lawrence Berkeley Laboratory UNIVERSITY OF CALIFORNIA, BERKELEY, CA Physics, Computer Science & Mathematics Division Submitted to Astrophyslcal Journal Letters SOUTHERN HEMISPHERE MEASUREMENTS OF THE ANISOTROPY IN THE COSMIC MICROWAVE BACKGROUND RADIATION RECEIVED * George F. Smoot and Phil M. Lubin ' LAWRENCE • BERKELEY LABORATORY JUL 121979 June 1979 LIBRARY AMD DOCUMENTS S E C T I O N •f This is a Library Circulating Copy which may be borrowed for two weeks. For a personal retention copy, call Tech. Info. Division, Ext. 6782 Prepared for the U. S. Department of Energy under Contract W-7405-ENG-48
Retinoic Acid Receptor, Cytosolic Retinol-Binding and Retinoic Acid-Binding Protein mRNA Transcripts and Proteins in Rat Insulin-Secreting Cells (1993)

To define the mechanism of vitamin A action at the beta-cell level, we tested for the presence of messenger RNA for retinoic acid receptors alpha, beta, and gamma; cytosolic retinol-binding protein; and cytosolic retinoic acid-binding protein in RINm5F cells, an insulin-secreting cell line, and determined whether cytosolic retinol-binding protein and cytosolic retinoic acid-binding protein are present in isolated purified normal rat beta-cells. Northern blot analyses showed two transcripts of retinoic acid receptor alpha messenger RNA (3.8 and 2.4 kb), one transcript of retinoic acid receptor messenger RNA (3.8 kb), and one transcript of cytosolic retinol-binding protein (0.9 kb) in RINm5F cells. Ribonuclease protection assays also showed the presence of cytosolic retinol-binding protein and cytosolic retinoic acid-binding protein in RINm5F cells. Quantitatively, cytosolic retinol-binding protein levels were 0.10 +/- 0.02 pg/micrograms total RNA. Using specific radioimmunoassays, normal isolated purified rat beta-cells contained CRBP (19.2 +/- 2.38) and cytosolic retinoic acid-binding protein (16 +/- 0.53 ng/10(6) cells). The presence of message for retinoic acid receptors alpha and gamma, cytosolic retinol-binding protein, cytosolic retinoic acid-binding protein, and the gene products of cytosolic retinol-binding protein and cytosolic retinoic acid-binding protein in insulin-secreting cells support a mechanism of vitamin A action and role for cytosolic and nuclear receptors at the beta-cell level similar to that suggested in nonendocrine cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Effect of Catalytic Stability Enhancement with Mono Aluminum Phosphate and Performance in Commercial FCC Unit (2015)

Fluid catalytic cracking (FCC) processes are now required to produce gasoline fractions with high octane number and less heavier fuel oil such as slurry oil (SLO), due to the need for environmental preservation and changes in the fuel oil demand structure. The authors previously discovered that addition of mono aluminum phosphate (Al–P) is effective to decrease heavier fuel oil and increase gasoline yield with higher octane number compared to conventional catalyst. In this study, catalyst containing Al–P was operated in the commercial FCC unit to verify the effect of Al–P. Catalyst containing Al–P achieved higher cracking activity and higher octane number than conventional catalyst. In addition, Al–P can suppress zeolite collapse under hydrothermal conditions.
Food uses of sunflower proteins (1979)

Abstract Commerical use of sunflower meal as a food product is dependent on the development of low chlorogenic acid cultivars and efficient procedures for dehulling the high oil cultivars and hybrids. Laboratory defatted sunflower flours have high protein contents, bland flavors, white colors at acid pH levels, and contain no antinutritive factors. Functional test data show that sunflower flours and protein concentrates have high salt solubility, oil absorption and oil emulsification. In rat feeding trials, the low lysine level in sunflower proteins has resulted in low protein efficiency ratios for sunflower diets and blends with cereals including bakery products. High weight gains are obtained for sunflower blends with legume and animal proteins, suggesting applications in milk and meat extenders and in soybean‐based infant, formulas. Heat treatments, mechanical agitation, and emulsifiers were effective in solubilizing 80% of sunflower proteins in extended milk formulations, and the product was given high ratings in taste panel evaluations. Sunflower flour slurries show excellent whippability and foam stability, comparable to that of soybean protein isolate, but lack the ability to form a firm gel. Wieners supplemented with sunflower products have low shrinkage and cooking losses, but rate poorly in organoleptic tests. Texturization of sunflower flour by extrusion cooking gave fibrous chunks which were greyish in appearance, but had a chewy texture, a meat‐like flavor, and gave low cooking losses in beef pattie formulations. Spun sunflower protein/casein (1:1) blends are superior to other vegetable proteins in shear strength, swellability and firmness. Sunflower flours are particularly deleterious to bread loaf characteristics. This effect can be partially overcome by autoclaving the flour, concentration of the protein, or addition of gluten, but the protein nutritive value of the supplemented bread is only marginally improved.
Bit-error-rate testing of high-power 30-GHz traveling-wave tubes for ground-terminal applications (1987)

Tests were conducted at NASA Lewis to measure the bit-error-rate performance of two 30-GHz 200-W coupled-cavity traveling-wave tubes (TWT's). The transmission effects of each TWT on a band-limited 220-Mbit/s SMSK signal were investigated. The tests relied on the use of a recently developed digital simulation and evaluation system constructed at Lewis as part ot the 30/20-GHz technology development program. This paper describes the approach taken to test the 30-GHz tubes and discusses the test data. A description of the bit-error-rate measurement system and the adaptations needed to facilitate TWT testing are also presented. A more comprehensive discussion of this topic appears in NASA publication TP-2635 [1].
Some aspects of the equation of state of monolayers (1935)

J. S. Mitchell and E. K. Rideal, Trans. Faraday Soc., 1935, 31, 980 DOI: 10.1039/TF9353100980
Illness behavior among patients with medically unexplained dizziness (2019)

Background: Dizziness is a common symptom to which patients seek ENT consultations. It is a symptom for which the cause can be either medical or psychological factors or both. Dizziness can cause significant distress and lead to multiple consultations. This study aimed to assess patterns of illness behaviors among patients with chronic dizziness and understand the underlying patterns. Methodology: Illness behavior was assessed by illness behavior questionnaire (IBQ), somatic symptoms by Scale for Assessment of Somatic Symptoms and diagnosis by the Diagnostic Criteria for Psychosomatic Research (DCPR) and International Classification of Diseases 10. Results: Of the 301 individuals, 24 had dizziness, most of these individuals had another somatic symptom and majority met criteria for health anxiety on DCPR. On the four subscales of IBQ, health concerns scores were higher in patients with dizziness as compared to other somatic symptoms. There was no significant difference between bodily distress, affective distress, and affective inhibition. Conclusions: This study concluded that patients with dizziness can also have other physical symptoms and high health anxiety and hence it may be necessary to screen patients for the same.
A combinatorial optimisation approach for closed-loop supply chain inventory planning with deterministic demand (2017)

Supply chains in equipment-intensive service industries often involve repair operations. In this context, tactical inventory planning is concerned with optimally planning supplies and repairs based on demand forecasts and in the face of conflicting business objectives. This paper considers closed-loop supply chains and proposes a mixed-integer programming model and a metaheuristic approach to this problem. The model is open to a variety of network topologies, site functions and transfer policies. It also accommodates multiple objectives by the means of a weighted cost function. We report experiments on pseudo-random instances designed to evaluate plan quality and impact of cost weightings. In particular, we show how appropriate weightings allow to implement common planning strategies (e.g., just-in-time replenishment, minimal repair). [Received 8 May 2016; Revised 24 October 2016; Accepted 2 December 2016]
Graphical Tools for Stability and Security Assessment (2014)

Power system stability and security assessment has been considered as an important control issue for secure system operation over many years. In this chapter, for the purpose of power system stability/security analysis and control synthesis, some graphical tools are introduced, that is, angle-voltage deviation, voltage-frequency deviation, frequency-angle deviation, and electromechanical wave propagation graphs. It explains the necessity of using the descriptive and graphical tools rather than pure analytical and mathematical approaches in wide-area power system stability and security issues. The improved situational awareness provided by phasor measurement units (PMUs) and wide-area monitoring systems (WAMSs) opens further improvements of graphical analysis, identification, and control tuning methods, providing robustness against unforeseen disturbances. The main purpose of these tools is easy monitoring to prevent instability and maintain an interconnected operation of the power system.
Transcriptional Regulation of SDHa Flavoprotein by Nuclear Respiratory Factor-1 Prevents Pseudo-hypoxia in Aerobic Cardiac Cells (2008)

Nuclear respiratory factor-1 (NRF-1) is integral to the transcriptional regulation of mitochondrial biogenesis, but its control over various respiratory genes overlaps other regulatory elements including those involved in O(2) sensing. Aerobic metabolism generally suppresses hypoxia-sensitive genes, e.g. via hypoxia-inducible factor-1 (HIF-1), but mutations in Complex II-succinate dehydrogenase (SDH), a tumor suppressor, stabilize HIF-1, producing pseudo-hypoxia. In aerobic cardiomyocytes, which rely on oxidative phosphorylation, we tested the hypothesis that NRF-1 regulates Complex II expression and opposes hypoxia-inducible factor-1. NRF-1 gene silencing blocked aerobic succinate oxidation, increasing nuclear HIF-1alpha protein prior to the loss of Complex I function. We postulated that NRF-1 suppression either specifically decreases the expression of one or more SDH subunits and increases succinate availability to regulate HIF-1 prolyl hydroxylases, or stimulates mitochondrial reactive oxygen production, which interferes with HIF-1alpha degradation. Using promoter analysis, gene silencing, and chromatin immunoprecipitation, NRF-1 was found to bind to the gene promoters of two of four nuclear-encoded Complex II subunits: SDHa and SDHd, but the enzyme activity was dynamically regulated through the catalytic SDHa flavoprotein. Complex II was inactivated by SDHa silencing, which led to aerobic HIF-1alpha stabilization, nuclear translocation, and enhanced expression of glucose transporters and heme oxygenase-1. This was unrelated to mitochondrial ROS production, reversible by high alpha-ketoglutarate concentrations, and coherent with regulation of HIF-1 by succinate reported in tumor cells. These findings disclose a novel role for NRF-1 in the transcriptional control of Complex II and prevention of pseudo-hypoxic gene expression in aerobic cardiac cells.
The Relationship between Structure and Activity in a Novel Series of Serum Cholesterol-Lowering Agents<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Relationship between Structure and Activity in a Novel Series of Serum Cholesterol-Lowering Agents1L. G. Humber, C. I. Chappel, A. V. Marton, M. Kraml, and J. DubucCite this: J. Med. Chem. 1966, 9, 3, 329–337Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/jm00321a015https://doi.org/10.1021/jm00321a015research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: The Synthesis and Application of the Mesoporous Molecular Sieves MCM‐41 — A Review (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In vitro Responsiveness of Testicular Interstitial Cells Isolated from Rats Acutely Treated with Estradiol Benzoate (1978)

Mature male Long-Evans rats were injected with 50 g estradiol benzoate (EB) and were killed at various times thereafter (0-8 h). Interstitial cells were prepared from 1 testis of each rat and were incubated in vitro either in the absence or in the presence of human chorionic gonadotropin (hCG). Under these conditions, interstitial cells from EB-treated rats were abbe to produce testosterone in vitro and were able to respond to a maximal dose of hCG in a manner similar to interstitial cells isolated from testes of rats which received the vehicle only.
Optical measurements as projection synthesis (1998)

We present an extension of the projection synthesis technique which allows us, at least in principle, to determine the probability distribution for any physical observable associated with a quantized optical field mode. This probability can be inferred from the photodetection statistics obtained by causing the field mode to be measured to interfere with a second mode prepared in a suitable reference state. We give an explicit expression for the required reference state. Weak-field homodyne detection using photon counting is, perhaps, the simplest system to which projection synthesis can be applied. We find the complete set of synthesized projectors for this system and show that they form a probability operator measure. We apply this set of projectors to study the discrimination between coherent states and to measure a quasiprobability distribution.
Effects of the Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib on Apolipoprotein B100 Metabolism in Humans (2006)

These data indicate that when used alone, torcetrapib reduces VLDL, IDL, and LDL apoB100 levels primarily by increasing the rate of apoB100 clearance. In contrast, when added to atorvastatin treatment, torcetrapib reduces apoB100 levels mainly by enhancing VLDL apoB100 clearance and reducing production of IDL and LDL apoB100.
Neuropathotyping: A New System to Classify Marek's Disease Virus (2002)

A statistical approach was used to establish a new classification system of Marek's disease virus (MDV) on the basis of neurologic responses. To develop the system, neurologic response data from 15x7 chickens inoculated with 30 strains of serotype 1 MDV were statistically analyzed by a cluster analysis. The goal was to identify a statistical system that would verify if three neurovirulence groups correlated with the three pathotypes previously described. The system was also validated in two additional strains of specific-pathogen-free (SPF) chickens, SPAFAS and line SC (Hy-Vac). The proposed system is based on analysis of three variables: 1) frequency of birds showing transient paralysis between 9 and 11 days postinoculation (dpi), (2) mortality before 15 dpi, and (3) frequency of birds showing persistent neurologic disease between 21 and 23 dpi. By use of this system, a MDV may be classified in one of three groups, designated neuropathotypes A, B, and C, which roughly correspond to the virulent, very virulent, and very virulent plus pathotypes, respectively. However, correlation between neuropathotype and pathotype was not absolute, and neuropathotyping is more a complement to the current pathotyping system than a replacement for it. Our results showed that neuropathotyping studies can be conducted in two types of commercial SPF chickens by the use of the same variables, although the system would first have to be standardized by the use of prototype viruses. Neuropathotypes can also be estimated with our statistical analysis with reasonable accuracy. By use of this analysis, we established that MDV strains within the very virulent pathotype may be subdivided into neuropathotypes B and C, thus establishing a previously unrecognized pathotypic classification. This finding illustrates how neuropathotyping may extend important information not identified by conventional pathotyping.
Stability analysis for reset systems with input saturation (2007)

This paper is devoted to the stability analysis for a class of reset systems, such as those including a Clegg integrator or a FORE (first order reset element). The system under consideration is subject to input saturation. Hence, constructive conditions, allowing to characterize the region of stability of the saturated closed-loop system, are proposed based on the use of some suitable Lyapunov functions and a modified sector condition. LMI-based optimization schemes for maximizing the size of the region of stability are then derived. In presence of an additive disturbance, the problem of L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> stability is also addressed.
Malware images (2011)

We propose a simple yet effective method for visualizing and classifying malware using image processing techniques. Malware binaries are visualized as gray-scale images, with the observation that for many malware families, the images belonging to the same family appear very similar in layout and texture. Motivated by this visual similarity, a classification method using standard image features is proposed. Neither disassembly nor code execution is required for classification. Preliminary experimental results are quite promising with 98% classification accuracy on a malware database of 9,458 samples with 25 different malware families. Our technique also exhibits interesting resilience to popular obfuscation techniques such as section encryption.
COMPUTER SIMULATIONS ON THERMAL PERFORMANCE OF A SEMI-UNDERGROUND HOUSE : Calculations related to the effect of various forms of underground insulation (1988)

In order to obtain the fundamental information on the thermal performance of a semi-underground house, calculations based on the two-dimensional finite element method were made for various forms of underground thermal insulations, as well as long-term field measurements using a twin-type test house. This paper describes the calculation results yielded by a series of parametric computer simulations using standard weather data of city of Sendai. Before a series of calculations, test calculations were made and it was confirmed that the calculated room temperature fluctuations approximately agree with measured fluctuations in the two test rooms. After the test calculations, the effect of the following factors on the room temperature fluctuation and on the heating and cooling loads was computed using room models whose size and building materials were similar to that of the test house: (1) Forms of thermal insulation around the underground walls (2) Solar incident through the windows and use of night insulation (3) Air conditioning mode (4) Thermal characteristics of soil around the construction In addition, the thermal performance of the semi-underground room was compared with other types of rooms (slab-on-grade type and basement type). Main results obtained by calculations are shown as follows: (1) There was little difference between the yearly mean temperatures for various forms of insulation. However, the difference between the maximum and minimum monthly mean room temperature was widely distributed between 8℃ and 16℃. The difference for the group of cases with horizontal insulation was smallest. (2) The heating and cooling loads of semi-underground rooms with various forms of insulation were about 0.5 times as large as that of the slab-on-grade room. (3) Under the situation of controlled room temperature between 18℃ and 26℃, the cooling loads in the case with insulation on the whole interior surface was highest in all cases of insulation formations. However, the cooling loads except this case were very low and there might be no need for any auxiliary cooling systems.
Linking of Utah genealogies to outpatient colonoscopy records defines familial aggregation of colorectal polyps and cancer (2010)

Background
The Utah Population Database (UPDB) is a shared research resource of the University of Utah. It combines Utah genealogies dating back to the 1700s with data from statewide resources, including a cancer registry, hospital claims, as well as birth and death certificates. A project completed in 2008 linked the UPDB to patient demographic records from Intermountain Healthcare which is a non-profit medical system that serves Utah and Southeast Idaho, providing care to approximately 60% of the resident population. The availability of large numbers of linked, electronically searchable medical records offers unique opportunities for improved clinical and outcomes research. We address the question of the extent to which colonic adenomas and hyperplastic polyps co-segregate with colon cancer risk in non-syndromic families.