gebhart/patrepeval huggingface dataset:
Some Properties of van der Waals' Liquids (1949)

A theoretical consideration of the volume of a van der Waals' liquid suggests some new rules, comparable to that of Trouton, relating coefficients of expansion and compressibility to heats of vaporization. According to the simplest and most reliable of these new relationships, the product of the coefficient of cubical expansion and the heat of vaporization, αΔHv, is the same for many liquids and equal to about 10 cal./deg. It is further shown that at a given temperature, ΔHv2β/V is also constant where β is the compressibility and V the volume of the liquid. Certain corollary rules are derived by combining the above two with each other and with Trouton's law. These new rules should prove of some value in estimating compressibilities and heats of vaporization from coefficients of expansion.
The Synthesis of Vitamin K<sub>1</sub><sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of Vitamin K11Ralph Hirschmann, Richard Miller, and N. L. WendlerCite this: J. Am. Chem. Soc. 1954, 76, 18, 4592–4594Publication Date (Print):September 1, 1954Publication History Published online1 May 2002Published inissue 1 September 1954https://pubs.acs.org/doi/10.1021/ja01647a026https://doi.org/10.1021/ja01647a026research-articleACS PublicationsRequest reuse permissionsArticle Views297Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rapid molecular cytogenetic analysis of X‐chromosomal microdeletions: Fluorescence in situ hybridization (FISH) for complex glycerol kinase deficiency (1995)

Diagnosis of X-chromosomal microdeletions has relied upon the traditional methods of Southern blotting and DNA amplification, with carrier identification requiring time-consuming and unreliable dosage calculations. In this report, we describe rapid molecular cytogenetic identification of deleted DNA in affected males with the Xp21 contiguous gene syndrome (complex glycerol kinase deficiency, CGKD) and female carriers for this disorder. CGKD deletions involve the genes for glycerol kinase, Duchenne muscular dystrophy, and/or adrenal hypoplasia congenita. We report an improved method for diagnosis of deletions in individuals with CGKD and for identification of female carriers within their families, using fluorescence in situ hybridization (FISH) with a cosmid marker (cosmid 35) within the glycerol kinase gene. When used in combination with an Xq control probe, affected males demonstrate a single signal from the control probe, while female carriers demonstrate a normal chromosome with two signals, as well as a deleted chromosome with a single signal from the control probe. FISH analysis for CGKD provides the advantages of speed and accuracy for evaluation of submicroscopic X-chromosomal deletions, particularly in identification of female carriers. In addition to improving carrier evaluation, FISH will make prenatal diagnosis of CGKD more readily available.
Cardiorespiratory effects of Pseudomonas and E. coli endotoxins in the awake dog (1977)

A comparison of the cardiovascular and respiratory effects of Pseudomonas aeruginosa and Escherichia coli endotoxins was investigated in the unanesthetized dog. Animals were anesthetized with halothane for placement of cardiovascular catheters and then allowed to awaken prior to collection of control data and experimentation. One group of 12 animals was given E. coli endotoxin (5 mg/kg), another group of 13 received Pseudomonas endotoxin (8 mg/kg). Variables were collected for 6 h after endotoxin injection. A third group of 13 animals serving as sham animals received no endotoxin. When major cardiovascular variables, such as arterial blood pressure, cardiac output, right atrial pressure, and left ventricular pressure and dP/dt were monitored, it was seen that the basic patterns of response to endotoxins were quite similar, with differences between groups being primarily quantitative. Analysis of respiratory data showed that animals receiving Pseudomonas developed an earlier respiratory response. Nevertheless, blood gas data were similar in the two groups.
Low Temperature Characterization of Tritium Contaminated Surfaces Used in Animal Studies (1995)

The behaviour of tritium in the body, as a result of intakes from contact with tritium contaminated surfaces and the subsequent radiation dose impact, is dependent on the nature of the tritium species. Research over the past few years has yielded important insight into the nature of tritiated species on surfaces exposed to elemental tritium. A significant drawback to understanding the relationship between tritium exposure and dose however is that most surface characterization data, reported in the literature, was generated at high temperature, whereas, exposure to tritiated surfaces occurs mostly at ambient temperature. In this paper we describe the results of characterization studies carried out at both ambient and high temperature. The well characterized stainless steel specimens were subsequently used in animal exposures.
Mono-, Di-, and Trinuclear Luminescent Silver(I) and Gold(I) N-Heterocyclic Carbene Complexes Derived from the Picolyl-Substituted Methylimidazolium Salt:  1-Methyl-3-(2-pyridinylmethyl)-1H-imidazolium Tetrafluoroborate (2005)

The N-heterocyclic carbene (NHC) precursor, 1-methyl-3-(2-pyridinylmethyl)-1H-imidazolium tetrafluoroborate, [HCH3im(CH2py)]BF4, reacted with AgBF4 in the presence of aqueous NaOH to produce the silver complex [Ag(CH3im(CH2py))2]BF4 (1) which was then reacted with Au(tht)Cl to form the corresponding gold(I) complex, [Au(CH3im(CH2py))2]BF4 (2). Complex 2 reacted with 1 equiv of AgBF4 to produce the mixed-metal species [AuAg(CH3im(CH2py))2](BF4)2 (3). The reaction of 2 with 1 equiv of Au(tht)Cl followed by metathesis with NaBF4 produces the dimetallic gold complex [Au2(CH3im(CH2py))2](BF4)2 (4). The reaction of [Ag(CH3im(CH2py))2]BF4 (1) with 1 equiv of AgBF4 produces the trinuclear [Ag3(CH3im(CH2py))3(NCCH3)2](BF4)3 (5) complex, which appears to dissociate into a dimetallic complex in solution. Complexes 1-5 were characterized by 1H NMR, 13C NMR, UV-vis, luminescence spectroscopy, elemental analysis, mass spectrometry, and X-ray crystallography. The CH3im(CH2py) ligands in 3 are arranged in a head-to-head fashion spanning a Au-Ag separation of 3.0318(5) A with the carbene portion of the ligand remaining coordinated to the Au(I) center. In 4, the ligands are arranged in a head-to-tail fashion with an Au-Au separation of 3.1730(5) A. In 5, the ligands bridge the nearly symmetrical Ag3 triangular core with short Ag-Ag separations of 2.7765(8), 2.7832(8), and 2.7598(8) A. All of these complexes, including the ligand precursor, are intensely luminescent in solution and the solid state.
Beta‐helix model for the filamentous haemagglutinin adhesin of <i>Bordetella pertussis</i> and related bacterial secretory proteins (2001)

Bordetella pertussis establishes infection by attaching to epithelial cells of the respiratory tract. One of its adhesins is filamentous haemagglutinin (FHA), a 500-A-long secreted protein that is rich in beta-structure and contains two regions, R1 and R2, of tandem 19-residue repeats. Two models have been proposed in which the central shaft is (i) a hairpin made up of a pairing of two long antiparallel beta-sheets; or (ii) a beta-helix in which the polypeptide chain is coiled to form three long parallel beta-sheets. We have analysed a truncated variant of FHA by electron microscopy (negative staining, shadowing and scanning transmission electron microscopy of unstained specimens): these observations support the latter model. Further support comes from detailed sequence analysis and molecular modelling studies. We applied a profile search method to the sequences adjacent to and between R1 and R2 and found additional "covert" copies of the same motifs that may be recognized in overt form in the R1 and R2 sequence repeats. Their total number is sufficient to support the tenet of the beta-helix model that the shaft domain--a 350 A rod--should consist of a continuous run of these motifs, apart from loop inserts. The N-terminus, which does not contain such repeats, was found to be weakly homologous to cyclodextrin transferase, a protein of known immunoglobulin-like structure. Drawing on crystal structures of known beta-helical proteins, we developed structural models of the coil motifs putatively formed by the R1 and R2 repeats. Finally, we applied the same profile search method to the sequence database and found several other proteins--all large secreted proteins of bacterial provenance--that have similar repeats and probably also similar structures.
Environmental Monitoring with Unmanned Aerial Vehicles (2020)

University of Minnesota Ph.D. dissertation. April 2020. Major: Computer Science. Advisor: Volkan Isler. 1 computer file (PDF); xvi, 127 pages.
Alternative-Splicing in the Exon-10 Region of GABAA Receptor β2 Subunit Gene: Relationships between Novel Isoforms and Psychotic Disorders (2009)

This study therefore provided experimental evidence for the importance of non-coding sequences in the Exon-10 region in GABRB2 with respect to beta(2)-subunit splicing diversity and the etiologies of SCZ and BPD.
Many-core virtual machines (2010)

We propose to search for common abstractions for concurrency models to enable multi-language virtual machines to support a wide range of them. This would enable domain-specific solutions for concurrency problems. Furthermore, such an abstraction could improve portability of virtual machines to the vastly different upcoming many-core architectures.
Osmotic Power Plants (1975)

1,0365MetricsTotal Downloads1,036Last 6 Months126Last 12 Months319Total Citations5Last 6 Months0Last 12 Months0View all metrics
Liquid Crystals with Large Negative Dielectric Anisotropy. Part V (1985)

Abstract Liquid crystals with negative Δϵ can be obtained by incorporating a cyano group in the terminal alkyl substituent or in an ethylene bridge between the cyclic units of the rigid core. The clearing points of such compounds are higher than those of the corresponding derivatives where the cyano group is laterally attached to a phenyl moiety. In compounds where both cyclic units of the rigid core are cyclohexyl, this type of substitution leads to an optimal contribution to ϵ⟂ in contrast to the cyanophenyl derivatives.
Design and Rapid Fabrication of a Microfluidic Fraction Collector (2002)

Article Design and Rapid Fabrication of a Microfluidic Fraction Collector was published on December 1, 2002 in the journal International Journal of Nonlinear Sciences and Numerical Simulation (volume 3, issue 3-4).
Effect of stoichiometry on sensing behavior of iron-gallium (2004)

Iron-Gallium alloys demonstrate moderate magnetostriction (~350 ppm) and saturation material induction (~1 T) under low magnetic fields (~400 Oe) as well as high tensile strength (~500 MPa) and limited dependence of magnetomechanical properties on temperatures between -20°C and 80°C, making them promising materials for sensing and actuation applications. However, the mechanical and magnetic properties of these materials vary significantly with the percentage of gallium, which motivates this study on the effect of stoichiometry on the behavior of Fe-Ga alloys. Major loop compressive tests (loading to 110 MPa and unloading, at magnetic fields ranging from 0 to 891 Oe) were performed on single crystal 19% Ga and 24% Ga samples with longitudinal axis in the [100] direction. The effect of % Ga on Young's modulus, saturation magnetization (M<sub>sat</sub>), ΔE-effect and d*<sub>33</sub> are discussed and explained. Furthermore, it was found that the magnetic field (H) through the sample changed with applied stress. A simple magnetic circuit analysis is developed in the latter part of the paper to model this effect. The ramification of both stoichiometry effects and variation in field on the design of Fe-Ga sensors is discussed.
Correlations of Free Thyroid Hormones Measured by Tandem Mass Spectrometry and Immunoassay with Thyroid-Stimulating Hormone across 4 Patient Populations (2009)

Free thyroid hormone concentrations measured by LC-MS/MS correlate to a greater degree with log TSH values compared to concentrations measured by immunoassay. This correlation was maintained across the patient populations we studied and may reflect the accuracy and specificity of LC-MS/MS. The superior ability of LC-MS/MS to enable documentation of the well-known thyroid hormone-TSH relationship supports the use of this measurement technique in a variety of clinical situations.
Analysis of exopolysaccharide production by Lactobacillus casei CG11, isolated from cheese (1992)

Exopolysaccharide-producing Lactobacillus casei CG11 was isolated from soft, white, homemade cheese. In basal minimal medium, it produces a neutral heteropolysaccharide consisting predominantly of glucose (about 75%) and rhamnose (about 15%). Plasmid curing experiments revealed that exopolysaccharide production by strain CG11 is linked to a plasmid approximately 30 kb in size.
Sinus Node Dysfunction in a Heart Transplant Patient Secondary to Severe Sinus Node Artery Obstruction (2003)

A case of sinus node dysfunction is reported secondary to severe sinus node artery obstruction 3 years after orthotopic heart transplantation. The patient first presented with frequent dizzy spells and presyncopal episodes for 3 months and then recurrent syncope in the presence of an acute myocardial infarction. Coronary angiography showed a diffusely narrowed sinus node artery without any apparent collateral vessels. The sinus node artery had had only minimal distal disease 3 months previously. A dual chamber permanent pacemaker was implanted with significant improvement in clinical symptoms.
Coma and metabolic acidosis related to the use of muscle liniment (1995)

van Wijngaarden, Mary MD FRCSC; Mock, Tom PhD; Dinwoodie, Alison PhD; LeGatt, Donald PhD FCACB; Yatscoff, Randall PhD FCACB Author Information
Calibration of Elemental Images in Integral Photography Capture for Electric Holography (2009)

To achieve high quality reconstruction of 3-D objects using integral photography technology, the elemental images must be calibrated if the display and capture modules do not use the same optical system. In this paper, we first introduce our real-time color holography system using integral photography capture and then describe the calibration method used in the system. Experimental results show our method can reduce the double reconstruction of 3-D objects.
Voltage-dependent block of endothelial volume-regulated anion channels by calix[4]arenes (1998)

We have studied the effects of calix[4]arenes on the volume-regulated anion channel (VRAC) currents in cultured calf pulmonary artery endothelial cells. TS- and TS-TM-calix[4]arenes induced a fast inhibition at positive potentials but were ineffective at negative potentials. Maximal block occurred at potentials between 30 and 50 mV. Lowering extracellular pH enhanced the block and shifted the maximum inhibition to more negative potentials. Current inhibition was also accompanied by an increased current noise. From the analysis of the calix[4]arene-induced noise, we obtained a single-channel conductance of 9.3 +/- 2.1 pS (n = 9) at +30 mV. The voltage- and time-dependent block were described using a model in which calix[4]arenes bind to a site at an electrical distance of 0.25 inside the channel with an affinity of 220 microM at 0 mV. Binding occludes VRAC at moderately positive potentials, but calix[4]arenes permeate the channel at more positive potentials. In conclusion, our data suggest an open-channel block of VRAC by calix[4]arenes that also depends on the protonation of the binding site within the pore.
Digital Blood Flow in Cooled and Contralateral Finger in Patients with Raynaud's Phenomenon. Comparative Measurements Between Photoelectrical Plethysmography and Laser Doppler Flowmetry (1992)

The effects of cooling of a hand on lateral and contralateral digital skin blood flow were investigated in 18 patients with primary or secondary Raynaud's phenomenon. The aim of the study was to compare photoelectrical plethsmography (PhEP) and laser Doppler flowmetry (LDF). PhEP and LDF were used simultaneously for skin blood flow measurements of the third finger of both hands. One hand was cooled in water from 33 degrees to 3 degrees C in steps of 3 degrees C, each step lasting four minutes. It was followed by a recovery period of ten minutes in room air of 24 degrees C. During stepwise cooling from 33 degrees to 9 degrees C the relative PhEP and LDF values, measured on the cooled hand, decreased to 6.2% +/- 3.2% and 10% +/- 12% respectively. The correlation coefficients between LDF and PhEP varied between 0.79 and 0.99. In the contralateral hand the relative PhEP and LDF values decreased to 38% +/- 30.% and 64% +/- 7.9% respectively. The correlation coefficients between LDF and PhEP values were lower on the contralateral hand and ranged from 0.26 to 0.95. By calculating the LDF/PhEP ratios during cooling and recovery, more specific changes in red blood cell velocities during cooling were studied. Increasing LDF/PhEP ratios suggest increasing red blood cell velocities during cooling at 9 degrees C and a difference in the measuring methods. For testing the severity of Raynaud's phenomenon and the effect of treatment the results of both methods show consistent and quite comparable results when measured on the cooled hand. The effect of indirect cooling on the contralateral hand is, however, less consistent.
<i>eskimo1</i>mutants of<i>Arabidopsis</i>are constitutively freezing-tolerant (1998)

Temperate plants develop a greater ability to withstand freezing in response to a period of low but nonfreezing temperatures through a complex, adaptive process of cold acclimation. Very little is known about the signaling processes by which plants perceive the low temperature stimulus and transduce it into the nucleus to activate genes needed for increased freezing tolerance. To help understand the signaling processes, we have isolated mutants of Arabidopsis that are constitutively freezing-tolerant in the absence of cold acclimation. Freezing tolerance of wild-type Arabidopsis was increased from -5.5 degreesC to -12.6 degreesC by cold acclimation whereas the freezing tolerance of 26 mutant lines ranged from -6.8 degreesC to -10.6 degreesC in the absence of acclimation. Plants with mutations at the eskimo1 (esk1) locus accumulated high levels of proline, a compatible osmolyte, but did not exhibit constitutively increased expression of several cold-regulated genes involved in freezing tolerance. RNA gel blot analysis suggested that proline accumulation in esk1 plants was mediated by regulation of transcript levels of genes involved in proline synthesis and degradation. The characterization of esk1 mutants and results from other mutants suggest that distinct signaling pathways activate different aspects of cold acclimation and that activation of one pathway can result in considerable freezing tolerance without activation of other pathways.
Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase (2017)

Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in <i>Saccharomyces cerevisiae</i> that couples spore morphogenesis to the completion of chromosome segregation. Similar to other MAPKs, Smk1 is controlled by phosphorylation of a threonine (T) and a tyrosine (Y) in its activation loop. However, it is not activated by a dual-specificity MAPK kinase. Instead, T207 in Smk1's activation loop is phosphorylated by the cyclin-dependent kinase (CDK)-activating kinase (Cak1), and Y209 is autophosphorylated in an intramolecular reaction that requires the meiosis-specific protein Ssp2. In this study, we show that Smk1 is catalytically inert unless it is bound by Ssp2. While Ssp2 binding activates Smk1 by a mechanism that is independent of activation loop phosphorylation, binding also triggers autophosphorylation of Y209 in Smk1, which, along with Cak1-mediated phosphorylation of T207, further activates the kinase. Autophosphorylation of Smk1 on Y209 also appears to modify the specificity of the MAPK by suppressing Y kinase and enhancing S/T kinase activity. We also found that the phosphoconsensus motif preference of Ssp2/Smk1 is more extensive than that of other characterized MAPKs. This study therefore defines a novel mechanism of MAPK activation requiring binding of an activator and also shows that MAPKs can be diversified to recognize unique phosphorylation motifs.
Gas Phase Reaction of Toluene Diisocyanate with Water Vapor (1984)

A study of the gas phase reaction of toluene diisocyanate (TDI) with water vapor has been conducted in a large (17.3 m3) environmental chamber. A number of analytical procedures were employed to follow the decay of TDI and to search for toluene diamine (TDA) and other reaction products. Experiments were conducted at ambient temperatures (27±1°C); relative humidity was varied from 7 to 70 percent. Four TDI concentrations were examined i.e. 0.6,0.2,0.1 and 0.05 ppm. No evidence was found for a gas phase reaction between TDI and H2O. This finding appears to contradict earlier studies of the reaction of TDI with water vapor. The observed TDI loss rate in the present study has been ascribed to physical removal process i.e. surface adsorption onto the walls of the environmental chamber. The results of this study cannot exclude the possibility that TDI reacts slowly with water vapor, but under the conditions of these experiments, adsorption on the wall surfaces takes place first. TDA and TDI-urea were searched for as possible reaction products; neither was observed.
A Study on Thermal Stabilization of Spent Foundry Sand (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.