gebhart/patrepeval huggingface dataset:
A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential (2013)

Thrombin, the major enzyme of the hemostatic system, is involved in biological processes associated with several human diseases. The capacity of a given individual to generate thrombin, called the thrombin generation potential (TGP), can be robustly measured in plasma and was shown to associate with thrombotic disorders. To investigate the genetic architecture underlying the interindividual TGP variability, we conducted a genome-wide association study in 2 discovery samples (N = 1967) phenotyped for 3 TGP biomarkers, the endogenous thrombin potential, the peak height, and the lag time, and replicated the main findings in 2 independent studies (N = 1254). We identified the ORM1 gene, coding for orosomucoid, as a novel locus associated with lag time variability, reflecting the initiation process of thrombin generation with a combined P value of P = 7.1 × 10(-15) for the lead single nucleotide polymorphism (SNP) (rs150611042). This SNP was also observed to associate with ORM1 expression in monocytes (P = 8.7 × 10(-10)) and macrophages (P = 3.2 × 10(-3)). In vitro functional experiments further demonstrated that supplementing normal plasma with increasing orosomucoid concentrations was associated with impaired thrombin generation. These results pave the way for novel mechanistic pathways and therapeutic perspectives in the etiology of thrombin-related disorders.
ChemInform Abstract: Synthesis of 1‐Alkylthio‐3H‐indolizin‐3‐ones. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An integrated phase noise measurement bench for on-chip characterization of resonators and VCOs (2011)

5 pages
Regional Osteoporosis in Anorexia Nervosa (2001)

Letters6 November 2001Regional Osteoporosis in Anorexia NervosaSteven Grinspoon, MD and Anne Klibanski, MDSteven Grinspoon, MDHarvard Medical School; Boston, MA 02114 (Grinspoon, Klibanski)Search for more papers by this author and Anne Klibanski, MDHarvard Medical School; Boston, MA 02114 (Grinspoon, Klibanski)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Mehler's comments. We have previously shown that leptin levels are tightly regulated by adipose tissue in women with the restricting subtype of anorexia nervosa (1). Recently, Ducy and colleagues (2) demonstrated that leptin itself may inhibit bone formation through central mechanisms in leptin-deficient and wild-type mice. In women with anorexia nervosa, we have found that low leptin levels are associated with osteopenia and osteoporosis (1). Therefore, we believe that in this population, leptin is more likely to be a marker of fat loss and generalized undernutrition than a determinant of bone density. We agree ...References1. Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, et al . Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab. 1996;81:3861-3. [PMID: 8923829] MedlineGoogle Scholar2. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, et al . Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 2000;100:197-207. [PMID: 10660043] CrossrefMedlineGoogle Scholar3. Mundy GR. Secondary osteoporosis: the potential relevance of leptin and low body weight [Editorial]. Ann Intern Med. 2000;133:828-30. [PMID: 11085846] LinkGoogle Scholar4. Klibanski A, Biller BM, Schoenfeld DA, Herzog DB, Saxe VC. The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J Clin Endocrinol Metab. 1995;80:898-904. [PMID: 7883849] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Steven Grinspoon, MD; Anne Klibanski, MDAffiliations: Harvard Medical School; Boston, MA 02114 (Grinspoon, Klibanski) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrevalence and Predictive Factors for Regional Osteopenia in Women with Anorexia Nervosa Steven Grinspoon , Elizabeth Thomas , Sarah Pitts , Erin Gross , Diane Mickley , Karen Miller , David Herzog , and Anne Klibanski Regional Osteoporosis in Anorexia Nervosa Philip S. Mehler Metrics Cited byComplicações clínicas da anorexia nervosa e bulimia nervosa 6 November 2001Volume 135, Issue 9Page: 844KeywordsAnorexia nervosaBone densityBone resorptionEstrogensLeptinMalnutritionNutritionOsteopeniaOsteoporosisPatients ePublished: 6 November 2001 Issue Published: 6 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Study of a Differential Demasking Technic for Serum Zinc (1962)

Abstract A differential decomplexation technic for the determination of serum zinc in filtrates was studied. It involved the masking of zinc, copper, and iron by the addition of cyanide to a buffered aliquot of an acid filtrate, followed first by the destruction of the excess cyanide and then the cyanide attached to zinc. The release of ionic zinc allowed reaction with the color reagent to take place. Quantitation with internal blanking was thereby accomplished before interference by other cations became possible.
Broadband stacked dielectric resonator antennas (1989)

The input impedance of stacked cylindrical dielectric resonator antennas is investigated experimentally. The dielectric resonators are made of different materials. The bandwidth of 25% has been observed for a standing wave ratio better than 2.
Comments on Transfer Scattering Reactor Kinetics (1972)

"Comments on Transfer Scattering Reactor Kinetics." Nuclear Science and Engineering, 48(3), pp. 370–371
Stabilization Mechanisms of Laminar Partially Premixed Flames from Domestic-Like Burner (2007)

Phenomena responsible of partially premixed laminar flame stabilization are investigated on a rich premixed burner configuration. The structure and aerodynamics of the flame generated by a cooking model burner are characterized by Planar Laser Induced Fluorescence of OH radical and Particle Image Velocimetry. The flame behaviour is studied from a stable reference case toward blow-out by varying the flow inlet conditions and the geometry of the burner. The flame structure and combustion regime are strongly modified. The flame can be considered as two neighbouring reactive zones, each consisting of a double edge flame having different behaviour toward to the flame blow-out. The stabilization of the upper double flame is similar to the stabilization of a Bunsen burner flame. The base is attached with a flame-holder mechanism and the flame tip position is controlled by the ratio between the flow velocity and the rich premixture flame speed. The bottom double flame is lifted and is stabilized thanks to local characteristics of mixing and aerodynamics.
A Clinical and Histopathological Review on 18 Cases of Lupus Erythematosus Tumidus (2010)

Background: Lupus erythematosus tumidus (LET) is a rare subset of chronic cutaneous lupus erythematosus, and LET is clinically characterized by erythematous, succulent, urticarial plaques on the sun-exposed areas and LET is histopathologically characterized by the presence of perivascular and periadnexal lymphocytic infiltrates with interstitial mucin deposition. Objective: We investigated the clinical and histopathological features of LET in Korean patients. Methods: A retrospective study was conducted on 18 patients who were diagnosed with LET between 1993 and 2010. The clinical characteristics, histopathological and laboratory findings, association with other subsets of lupus and the course of disease were analyzed. Results: LET occurred predominantly in females, with the gender ratio being 1:8. The mean age at diagnosis was 31.3 years. Two of 18 patients (11.1%) were previously diagnosed with systemic lupus erythematosus (SLE) or they had discoid lupus erythematosus (DLE) simultaneously. The most common clinical features were erythematous patches, nodules or plaques and the most common site was the face. Eight of eighteen patients (44.4%) had photosensitivity and this value was lower than that of the previous reports. The antinuclear antibody (ANA) was negative or weakly positive in 13/15 (86.7%) cases. The main histopathological characteristics were perivascular and/or periadnexal lymphocytic infiltrates, and interstitial mucin deposition. Epidermal changes were absent or there were minimal changes. The treatments included antimalarial drugs, dapsone and topical and systemic corticosteroid. The patients showed a good response to the treatments without scarring. Conclusion: A clinicopathological review of 18 LET cases revealed results that were similar to those of the previous reports, although there were some differences in the gender ratio and frequency of photosensitivity. Further studies are needed to elucidate the cause of such differences.
ChemInform Abstract: SYNTHESIS OF O‐AMINOTHIOPHENOLS (1980)

Abstract Durch reduktive Desaminierung der Aminobenzthiazole (I) werden die Benzthjazole (II) erhalten, die mit Hydrazinhydrat zu den o‐Aminothiophenolen (III) gespalten werden.
Digitalrechner (1997)

Beginnend in Kap. 7 haben wir uns mit den Schaltnetzen und Schaltwerken zunächst die Grundlagen der logischen Schaltungen erarbeitet. Im vorhergehenden Kapitel haben wir daraus dann beispielhaft verschiedene Funktionseinheiten zusammengestellt, die in den unterschiedlichsten digitalen Komponenten immer wieder zu finden sind. Mit diesem Wissen sind wir nun auch in der Lage, unser eigentliches Ziel anzugehen, nämlich den Digitalrechner in der Gesamtheit seines Aufbaus und seiner Wirkungsweise zu erfassen. Dies soll die Aufgabe des vorliegenden Kapitels sein. Danach soll der Leser mit den in einem Digitalrechner ablaufenden grundsätzlichen Mechanismen vertraut und je nach Neigung zur Vertiefung seiner Kenntnisse in der Lage sein, von dieser Plattform aus Brücken zum weiten Gebiet der Rechnerorganisation und Rechnerarchitektur zu schlagen.
Effects of Low-<i>k</i>Stack Structure on Performance of Complementary Metal Oxide Semiconductor Devices and Chip Package Interaction Failure (2012)

Low capacitance and highly reliable Cu dual-damascene (DD) interconnects have been developed with self-organized "seamless low-k SiOCH stacks" (SEALS) structure. A carbon-rich sub-nano porous SiOCH (k=2.5) was directly stacked on an oxygen-rich porous SiOCH (k=2.7) in the SEALS structure, without a hard-mask (HM) and etch-stop (ES) layer of SiO2. The effective k-value (keff) of the Cu DD interconnect including the SiCN capping layer (k=4.9) was reduced to 2.9 compared to 3.4 on a conventional hybrid structure with SiO2-HM and ES, which had been used in 65-nm-node mass production. The interconnect delay of a 45-nm-node complementary metal oxide semiconductor (CMOS) ring oscillator (RO) was reduced by 15% referring to that of the conventional hybrid structure. Interconnect reliabilities, such as the interline time dependent dielectric breakdown (TDDB) and thermal cycles, were unchanged from those of the conventional hybrid interconnects. No failure was detected for chip package interaction (CPI) during reliability tests in a plastic ball grid array (PBGA) package. SEALS is a promising structure for scaled down ultra large scale integrations (ULSIs) for highly reliable and high speed operation, and low power consumption.
Crystal structure of racemic <i>trans</i>-2-(4-methylphenyl)-cyclohexanol (1994)

Abstract The title compound was obtained by a copper-assisted ring opening reaction of cyclohexene oxide using 4-methylphenyl-magnesium-bromide. It crystallizes from n-pentane in the triclinic system, space group P [unk], with a = 1122.0(6) pm, b = 1174.5(5) pm, c = 917.2(3) pm, α = 107.11(3)°, β = 90.69(4)°, γ = 76.18(4)°.
Characterization of two trehalases in baker's yeast (1984)

Trehalase activities at pH 5 (not inhibited by EDTA) and pH 7 (inhibited by EDTA) were present in the soluble fraction of disintegrated commercial baker's yeast. The pH 5 activity binds strongly to concanavalin A, is only partially salted out by saturated (NH4)2SO4, has an apparent Mr of 215000 (by gel filtration) and is an acidic protein. It has a Km of 1.4 mM, a broad pH optimum (at 40 mM-trehalose) between pH 4 and 5, and is activated by about 30% by 20-300 mM neutral salts such as KCl, NaNO3 and MnCl2. The enzyme is strongly inhibited by acetic acid/acetate buffers, with a Ki of about 15 mM-acetic acid. The pH 7 activity does not bind to concanavalin A, is salted out at 20-32% (w/v) (NH4)2SO4 and has an Mr of 170000 (by gel filtration). It is absolutely dependent on Ca2+ or Mn2+ ions (Mg2+ is ineffective) and strongly inhibited by neutral salts in the 20-100 mM range. It can be activated by treatment with MgATP in the presence of cyclic AMP. Activation decreases, but does not abolish, the Ca2+ requirement, and does not change the Km for trehalose (5.7 mM) or shift the sharp pH optimum at pH 6.7 (at 40 mM-trehalose).
p53-Responsive miR-194 Inhibits Thrombospondin-1 and Promotes Angiogenesis in Colon Cancers (2011)

Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal cancers (CRC), its expression is sustained or even slightly increased despite frequent loss of p53. Here, we determined that in HCT116 CRC cells, p53 activates the THBS1 primary transcript, but fails to boost THBS1 mRNA or protein levels, implying posttranscriptional regulation by microRNAs (miRNA). In a global miRNA gain-of-function screen done in the Dicer-deficient HCT116 variant, several miRNAs negatively regulated THBS1 mRNA and protein levels, one of them being miR-194. Notably, in agreement with published data, p53 upregulated miR-194 expression in THBS1 retrovirus-transduced HCT116 cells, leading to decreased TSP-1 levels. This negative effect was mediated by a single miR-194 complementary site in the THBS1 3'-untranslated region, and its elimination resulted in TSP-1 reactivation, impaired angiogenesis in Matrigel plugs, and reduced growth of HCT116 xenografts. Conversely, transient overexpression of miR-194 in HCT116/THBS1 cells boosted Matrigel angiogenesis, and its stable overexpression in Ras-induced murine colon carcinomas increased microvascular densities and vessel sizes. Although the overall contribution of miR-194 to neoplastic growth is context dependent, p53-induced activation of this GI tract-specific miRNA during ischemia could promote angiogenesis and facilitate tissue repair.
Interval generalized stochastic petri net models in dependability evaluation (2007)

Interval arithmetic has been applied to model uncertainties and variabilities. An interval model is a space, family or class of models in which there are parameters represented by intervals, instead of real numbers. This paper describes the interval generalized stochastic Petri net (IGSPN) as an interval extension to the GSPN model. The IGSPN analysis takes into account the effects of variability on exponential transition rates and weights when calculating dependability measures. IGSPN analysis may be useful as a tool for decisionmaking. A Case study is presented for describing the models as well as for presenting the analysis methods.
ChemInform Abstract: N‐Acyliminium Cyclizations via Reversible 2‐Aza‐Cope Rearrangements. (1986)

Abstract Aus den Hydroxy‐lactamen (I) erhält man über die im Gleichgewicht stehenden Kationen (II) bzw. (III) je nach Bedingungen unterschiedliche Reaktionsprodukte.
Birth/birth-death processes and their computable transition probabilities with biological applications (2016)

Birth-death processes track the size of a univariate population, but many biological systems involve interaction between populations, necessitating models for two or more populations simultaneously. A lack of efficient methods for evaluating finite-time transition probabilities of bivariate processes, however, has restricted statistical inference in these models. Researchers rely on computationally expensive methods such as matrix exponentiation or Monte Carlo approximation, restricting likelihood-based inference to small systems, or indirect methods such as approximate Bayesian computation. In this paper, we introduce the birth(death)/birth-death process, a tractable bivariate extension of the birth-death process. We develop an efficient and robust algorithm to calculate the transition probabilities of birth(death)/birth-death processes using a continued fraction representation of their Laplace transforms. Next, we identify several exemplary models arising in molecular epidemiology, macro-parasite evolution, and infectious disease modeling that fall within this class, and demonstrate advantages of our proposed method over existing approaches to inference in these models. Notably, the ubiquitous stochastic susceptible-infectious-removed (SIR) model falls within this class, and we emphasize that computable transition probabilities newly enable direct inference of parameters in the SIR model. We also propose a very fast method for approximating the transition probabilities under the SIR model via a novel branching process simplification, and compare it to the continued fraction representation method with application to the 17th century plague in Eyam. Although the two methods produce similar maximum a posteriori estimates, the branching process approximation fails to capture the correlation structure in the joint posterior distribution.
Abstract 2959: Peptide-linked indolino-benzodiazepine DNA-alkylating agents for use in antibody-drug conjugates (ADCs) (2016)

Abstract As part of our efforts to expand the available toolbox of cytotoxic payloads for use in antibody-drug conjugates (ADCs), we have recently described the development of the mono-imine-containing indolino-benzodiazepine dimer, IGN-P1 (Miller, et al., AACR 2014 #652). IGN-P1 was conjugated via a protease-cleavable peptidic L-alanine-L-alanine linker to a folate receptor α (FRα)-binding antibody, and an EGFR-binding antibody. The resulting ADCs demonstrated high in vitro potency (IC50 ∼4-100 pM) and specificity towards several cancer cell lines. In vivo, anti-FRα-IGN-P1 induced complete regressions in NCI-H2110 non-small cell lung cancer xenografts following a single dose of 3 μg/kg (linked payload dose, equivalent to 0.18 mg/kg Ab dose). Here we describe the structure-activity relationship of a number of peptide-linked IGN ADCs, leading to the selection of Ab-IGN-P1 for further advancement. The cytotoxic activities of these peptide-IGN conjugates were evaluated in vitro in cancer cell lines with both high and low target antigen expression. We also assessed bystander activity and identified in vitro and in vivo catabolites. We found that the stereochemistry of the peptide linker was crucial for bystander activity and in vivo efficacy. The IGN-P1 ADC exhibited strong bystander activity, which we believe is dictating the strong antitumor activity in vivo. Treatment of low to moderate antigen-expressing models with Ab-IGN-P1 further resulted in tumor regressions at doses as low as 3-10 μg/kg linked payload. These data underscore the potential therapeutic benefit of highly active and specific IGN-P1 conjugates, even for the challenging subset of patients with solid tumors where the target antigen is expressed at lower levels. Citation Format: Manami Shizuka, Alan Wilhelm, Katie Archer, Emily Reid, Nicholas C. Yoder, Chen Bai, Nathan Fishkin, Luke Harris, Erin Maloney, Erica Hong, Rui Wu, Olga Ab, Kate Lai, Surina Sikka, Shan Jin, Jan Pinkas, Ravi Chari, Michael L. Miller. Peptide-linked indolino-benzodiazepine DNA-alkylating agents for use in antibody-drug conjugates (ADCs). [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2959.
Glial Cell Line-Derived Neurotrophic Factor Rescues Target-Deprived Sympathetic Spinal Cord Neurons But Requires Transforming Growth Factor-β as Cofactor<i>In Vivo</i> (1999)

Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for several populations of CNS and peripheral neurons. Synthesis and storage of GDNF by the neuron-like adrenal medullary cells suggest roles in adrenal functions and/or in the maintenance of spinal cord neurons that innervate the adrenal medulla. We show that unilateral adrenomedullectomy causes degeneration of all sympathetic preganglionic neurons within the intermediolateral column (IML) of spinal cord segments T7-T10 that project to the adrenal medulla. In situ hybridization revealed that IML neurons express the glycosylphosphatidylinositol-linked alpha receptor 1 and c-Ret receptors, which are essential for GDNF signaling. IML neurons also display immunoreactivity for transforming growth factor-beta (TGF-beta) receptor II. Administration of GDNF (recombinant human, 1 microg) in Gelfoam implanted into the medullectomized adrenal gland rescued all Fluoro-Gold-labeled preganglionic neurons projecting to the adrenal medulla after four weeks. Cytochrome c applied as a control protein was not effective. The protective effect of GDNF was prevented by co-administration to the Gelfoam of neutralizing antibodies recognizing all three TGF-beta isoforms but not GDNF. This suggests that the presence of endogenous TGF-beta was essential for permitting a neurotrophic effect of GDNF. Our data indicate that GDNF has a capacity to protect a population of autonomic spinal cord neurons from target-deprived cell death. Furthermore, our results demonstrate for the first time that the previously reported requirement of TGF-beta for permitting trophic actions of GDNF in vitro (Kreiglstein et al., 1998) also applies to the in vivo situation.
Loudness asymmetry ratings between accelerating and decelerating car sounds (2008)

cote interne IRCAM: Susini08a
Generalized history table for branch prediction (in pipeline computers) (1982)

The idea set forth is for all the information that allows for a highly accurate prediction of branches to be kept in a generalized table.
Restoring the Co Magnetic Moments at Interfacial Co-Porphyrin Arrays by Site-Selective Uptake of Iron (2015)

Magnetochemistry recently emerged as a promising approach to control addressable spin arrays on surfaces. Here we report on the binding, spatial ordering, and magnetic properties of Fe on a highly regular Co-tetraphenylporphyrin (Co-TPP) template and highlight how the Fe controls the magnetism of the Co centers. As evidenced by scanning tunneling microscopy (STM) single Fe atoms attach to the saddle-shape conformers site-selectively in a unique coordination environment offered through a heptamer defined by the Co-N-C-C-C-N cyclic subunit. While the magnetic moment of Co is quenched for bare Co-TPP/Ag(111), the Fe presence revives it. Our X-ray magnetic circular dichroism (XMCD) experiments, complemented by density functional theory (DFT) calculations, evidence a ferromagnetic coupling between the Fe and the Co center concomitant with a complex charge redistribution involving the porphyrin ligand. Thus, we demonstrate an unusual metalloporphyrin coordination geometry that opens pathways to spatially order and engineer magnetic moments in surface-based nanostructures.