gebhart/patrepeval huggingface dataset:
ANDROGEN RESPONSIVE AND REFRACTORY PROSTATE CANCER CELLS EXHIBIT DISTINCT CURCUMIN REGULATED TRANSCRIPTOME (2008)

You have accessJournal of Urology1 Apr 2008ANDROGEN RESPONSIVE AND REFRACTORY PROSTATE CANCER CELLS EXHIBIT DISTINCT CURCUMIN REGULATED TRANSCRIPTOME Rajeesh L Thangapazham, Syed M Shaheduzzaman, Kee-Hong Kim, Neena Passi, Albert Dobi, Shiv Srivastava, and Radha Maheshwari Rajeesh L ThangapazhamRajeesh L Thangapazham More articles by this author , Syed M ShaheduzzamanSyed M Shaheduzzaman More articles by this author , Kee-Hong KimKee-Hong Kim More articles by this author , Neena PassiNeena Passi More articles by this author , Albert DobiAlbert Dobi More articles by this author , Shiv SrivastavaShiv Srivastava More articles by this author , and Radha MaheshwariRadha Maheshwari More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60553-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ANDROGEN RESPONSIVE AND REFRACTORY PROSTATE CANCER CELLS EXHIBIT DISTINCT CURCUMIN REGULATED TRANSCRIPTOME." The Journal of Urology, 179(4S), pp. 190–191 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 190-191 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Rajeesh L Thangapazham More articles by this author Syed M Shaheduzzaman More articles by this author Kee-Hong Kim More articles by this author Neena Passi More articles by this author Albert Dobi More articles by this author Shiv Srivastava More articles by this author Radha Maheshwari More articles by this author Expand All Advertisement PDF downloadLoading ...
Population models in Gammarus (Crustacean) and Potamopyrgus (Gastropod): depicting the seasonal variability in demographic sensitivities to toxic stress by sensitivity analysis (2011)

Today there exists a large consensus that ecological models with populations rather than individuals as targets to protect have a high potential to be implemented into ecotoxicological risk assessment [1]. Indeed, they revealed particularly useful to solve the challenging issue of extrapolating toxic effects measured at the individual level towards possible contamination impacts on\npopulations. Nevertheless, with the perspective to project or predict population answer, the environmental relevance of these models has to be improved, accounting for variability in population vulnerability and making them transferable with native species. In this way, the extrapolation process could be also used within a diagnostic framework. Our work was focused on two phylogenetically and ecologically contrasted species (the Crustacean Amphipod Gammarus fossarum and the Mollusk Gastropod Potamopyrgus antipodarum), widely present in European rivers and for which ecotoxicological (sub)individual biomarkers are available. We first developed environmentally realistic size-structured population models including both in situ caging and laboratory data, and relating individual-level demographic parameters (survival, growth, reproductive activity, fecundity, size at maturity) to the dynamics of reference native populations all along a year. Second, this methodology was coupled with in situ biotests or laboratory bioassays, in order to allow a population-level assessment of water quality or chemical compound toxicity. We showed thus the relevance to take into account the phenology of population dynamics (seasonal variability), by illustrating how it strongly controls the demographic sensitivity to toxic alteration of individual fitness traits in native species. More precisely, the poster will exemplify how sensitivity analyses of population endpoints were able to improve the comprehensive evaluation of possible contamination impacts on ecologically relevant biological levels.
Terahertz spectroscopy of inorganic glasses and carbon nanotubes (2011)

Terahertz spectroscopy is a relatively recent experimental technique to perform vibrational spectroscopy in the far infrared region of the elctromagnetic spectrum. Terahertz spectroscopy is performed as a time-domain experiment which leads to a high signal-to-noise ratio at low frequencies as well as the ability to measure both amplitude and phase experimentally. This chapter outlines how these properties can be exploited for the analysis of inorganic glasses and carbonacous materials beyond what is possible with conventional far infrared spectroscopy.
Reconstruction of the deep history of "Parent-Daughter" relationships among vertebrate paralogs (2018)

Gene duplication is a major mechanism through which new genetic material is generated. Although numerous methods have been developed to differentiate the ortholog and paralogs, very few differentiate the "Parent-Daughter" relationship among paralogous pairs. As coined by the Mira et al, we refer the "Parent" copy as the paralogous copy that stays at the original genomic position of the "original copy" before the duplication event, while the "Daughter" copy occupies a new genomic locus. Here we present a novel method which combines the phylogenetic reconstruction of duplications at different evolutionary periods and the synteny evidence collected from the preserved homologous gene orders. We reconstructed for the first time a deep evolutionary history of "Parent-Daughter" relationships among genes that were descendants from 2 rounds of whole genome duplications (2R WGDs) at early vertebrates and were further duplicated in later ceancestors like early Mammalia and early Primates. Our analysis reveals that the "Parent" copy has significantly fewer accumulated mutations compared with the "Daughter" copy since their divergence after the duplication event. More strikingly, we found that the "Parent" copy in a duplication event continues to be the "Parent" of the younger successive duplication events which lead to "grand-daughters".
Association of HLA profiles with early plasma viral load, CD4+ cell count and rate of progression to AIDS following acute HIV-1 infection (1998)

The means by which the HLA score profile influences the time to AIDS is probably through immunologic responses that affect the rate of HIV-1 replication, as manifested by the HIV-1 RNA plasma viral load during the first 6-12 months following acute infection.
ADAM‐10 and ADAM‐17 in the inflamed human CNS (2003)

Inflammatory demyelinating disorders of the CNS, such as multiple sclerosis (MS), are mediated, at least in part, by various cytokines and proteases. In the present study, we investigated the expression of A disintegrin and metalloproteinase (ADAM)-17, an important sheddase for various proteins, including tumor necrosis factor-alpha (TNF-alpha), and the p75- and p55-TNF receptors, as well as ADAM-10, a protease implicated in myelin degradation, in post mortem CNS tissue samples from patients with MS, and normal brain tissue (as control) by immunohistochemistry. ADAM-10 was found to be expressed by astrocytes in all MS and control sections studied; however, in some MS sections, perivascular macrophages were determined as an additional cellular source as well. ADAM-17 could be observed exclusively in acute and chronic active MS plaques and localized to invading T lymphocytes. The staining pattern of ADAM-17 in MS plaques was mirrored in distribution and extent by the pattern obtained with an antibody against the p75-TNF-receptor (TNFR-2), whereas TNF-alpha was found to be expressed primarily by perivascular macrophages. In studying cerebrospinal fluid (CSF) samples from MS patients, we were able to detect increased protein levels of ADAM-17 as compared with noninflammatory controls. In addition, increased levels of soluble TNFR-2 could be measured, suggestive of an active shedding process mediated by ADAM-17. The stimulation of peripheral blood mononuclear cells (PBMC) obtained from MS patients and healthy individuals corroborated these findings by revealing expression of ADAM-17 by T lymphocytes and ADAM-10 by macrophages in vitro. Our results indicate that ADAM-10 is expressed constitutively by astrocytes in the normal and inflamed human CNS. In contrast, under inflammatory conditions, ADAM-10, expressed by perivascular macrophages, and ADAM-17, expressed by invading T cells, may actively contribute to the pathogenesis of inflammatory disorders of the CNS.
Molecular mechanisms of Nod factor diversity (1997)

The rhizobia-legume symbiosis is highly specific. Major host specificity determinants are the bacterial Nod factor signals that trigger the nodulation programme in a compatible host. Nod factors are lipo-chitooligosaccharides (LCOs) varying in the oligosaccharide chain length, the nature of the fatty acids and substitutions on the oligosaccharide. The nod genotype of rhizobia, which forms the genetic basis for this structural variety, includes a set of nodulation genes encoding the enzymes that synthesize LCOs. Allelic and non-allelic variation in these genes ensures the synthesis of different LCO structures by the different rhizobia. The nod genotypes co-evolved with host plant divergence in contrast to the rhizobia, which followed a different evolution. Horizontal gene transfer probably played an important role during evolution of symbiosis. The nod genotypes are particularly well equipped for horizontal gene transfer because of their location on transmissible plasmids and/or on 'symbiosis islands', which are symbiotic regions associated with movable elements.
Standard surgical treatment for benign prostatic hyperplasia is safe for patients over 75 years: Analysis of 100 cases from a high-volume urologic center (2012)

Standard surgical treatments for benign prostatic hyperplasia are safe and satisfactory among the elderly. Complications are infrequent, and urethral stenosis is the most common. No clinical variable is associated with the occurrence of complications.
The Study of Primordial Germ Cell Development as a Tool for Gene Transfer in Chickens (1991)

The ability to introduce novel genetic material into the genome of commercial poultry has been impeded by a lack of kowledge regarding the origin in the early embryo of the target cell of interest, namely, the germ cell. Hence, this project investigated the emergence of primordial germ cells (PGCs) during the early development of the avian embryo to aid in efforts to produce transgenic poultry on a routine basis. The strategy was to introduce foreign DNA into the area of the unincubated embryo that is destined to give rise to the germ line. The objectives of this project were: 1) to identify and localize a subpopulation of cells in the early embryo which will give rise to PGCs, 2) to determine the best location and stage of development to transfer donor cells for efficient germline chimerism, and 3) to transfect donor cells to produce transgenic/germline chimeric embryos. We show that by using the monoclonal antibody SSEA-1 and by various cell culture techniques that germ cells appear to segregate from the somatic lineages at St. X., a process that is gradual and continues through St. XIV. Using microsurgical transplantation between quail and chick embryos, we demonstrated that the inner 1/3 of the area pellucida between states X-XII gives rise to about 2/3 of the germ cell population at the time of their residence in the germinal crescent. Because of the non-localized emergence of PGCs, attempts to introduce foreign DNA into clonal precursors of germ cells through liposome-mediated transfection yielded unacceptable levels of efficiency. However, through our investigation of germ cell origins, an in vitro model of germ cell differentiation was developed that could offer a means of determining the factors required for the long term culture of avian PGCs thereby providing a convenient means of manipulating the avian genome.
Isomorphism in monomeric 1:3 complexes of silver(I) salts with tri-<i>p</i>-tolylphosphine (2009)

Reaction of silver(I) salts with three equivalents of tri-p-tolylphosphine in CH(3)CN resulted in a series of isomorphous complexes [AgX{P(4-MeC(6)H(4))(3)}(3)] (X = Br, SCN, ClO(4)). These complexes all crystallize in the orthorhombic space group Pna2(1). The complexes with X = Br, SCN are distorted tetrahedral around the silver(I) atom, whereas the ClO(4)(-) complex is distorted trigonal planar around the silver. The new complexes are compared with each other using r.m.s. overlay calculations as well as half-normal probability plot analysis and with the previously reported isomorphous chloride, bromide as well as the non-isomorphous iodide complexes.
Preparation and Properties of Self-Assembled Discotic Liquid Crystals Formed by Hydrogen Bonding (2014)

페놀과 피리딘 간의 단일 수소결합을 이용하여 새로운 형태의 자기 집합된 원반형 액정을 제조하고 그 액정 특성을 조사하였다. 원반형 구조 설계를 위해 phloroglucinol을 중심부 분자로, 체계적으로 알킬사슬 길이를 변화시킨 trans-4-alkoxy-4'-stilbazole을 주변 물질로 사용하였다. 적외선 분광 분석을 통해 중심부 분자와 주변 물질 사이의 분자간 수소결합이 성공적으로 형성됨을 확인하였고, 또한 수소결합의 안정성이 분자 정렬에 의해 크게 영향을 받음을 확인하였다. 자기 집합된 원반형 액정 복합체는 원반형 메소겐 주위의 알킬 사슬 길이에 따라 다른 액정상들을 나타내었다. 긴 알킬사슬을 함유하는 액정 복합체의 경우 육방형 컬럼상이 나타났으며, 상대적으로 짧은 사슬을 갖는 다른 액정 복합체에서는 네마틱 컬럼상이 형성되었다. 이는 자기 집합된 원반형 액정 복합체의 액정상 구조가 원반형 핵 단위 주변의 알킬사슬 길이에 의해 크게 영향을 받음을 의미하였다. New self-assembled discotic liquid crystals have been prepared through single hydrogen bonding between phenol and pyridine moieties, and their liquid crystalline properties were investigated. For the construction of discotic structure, we used phloroglucinol as a core molecule and trans-4-alkoxy-4'-stilbazoles with systematically varied alkyl chain lengths as peripheral units. FTIR results showed that the intermolecular hydrogen bonds between core and peripheral molecules are successfully formed, and the stability of the hydrogen bond is strongly influenced by molecular ordering. Discotic complexes exhibited different liquid crystalline phases depending on the length of alkyl chains around the discotic mesogen. The discotic complexes with longer alkyl chains showed hexagonal columnar mesophases, while the other complexes formed nematic columnar mesophases. These results indicated that the type of mesophase structure was strongly dependent on the alkyl chain length around the aromatic core.
Progression Risk of Idiopathic Juvenile Scoliosis During Pubertal Growth (2006)

Curve pattern, Cobb angle at onset of puberty, and curve progression velocity are strong predictive factors of curve progression. Juvenile scoliosis > 30 degrees increases rapidly and presents a 100% prognosis for surgery (curve > 40 degrees to 45 degrees ). Anticipation is necessary if the scoliosis progresses during the first year of puberty. The prediction is difficult for curves of 21 degrees to 30 degrees during the first 2 years of puberty. Curve pattern and curve progression velocity are useful to detect which curves are likely to progress. From this retrospective analysis, spinal fusion could have been indicated earlier sometimes. An earlier intervention is probably preferable to obtain better curve reduction on a supple spine, even if a perivertebral fusion is necessary. We use the 3 parameters for operative indications. If an early spinal fusion leads to better curve correction needs to be verified on prospective data.
Improving TCP/IP Performance over Third-Generation Wireless Networks (2008)

As third-generation (3G) wireless networks with high data rate get widely deployed, optimizing the transmission control protocol (TCP) performance over these networks would have a broad and significant impact on data application performance. In this paper, we make two main contributions. First, one of the biggest challenges in optimizing the TCP performance over the 3G wireless networks is adapting to the significant delay and rate variations over the wireless channel. We present window regulator algorithms that use the receiver window field in the acknowledgment (ACK) packets to convey the instantaneous wireless channel conditions to the TCP source and an ACK buffer to absorb the channel variations, thereby maximizing long-lived TCP performance. It improves the performance of TCP selective ACK (SACK) by up to 100 percent over a simple drop-tail policy, with small buffer sizes at the congested router. Second, we present a wireless channel and TCP-aware scheduling and buffer sharing algorithm that reduces the latency of short flows while still exploiting user diversity for a wide range of user and traffic mix.
Transparent Polycrystalline Alumina Ceramics with Orientated Optical Axes (2008)

A novel method is reported for the manufacture of transparent polycrystalline alumina ceramics by means of orientating the optical axes of grains parallel to each other. Such ceramics were achieved simply by exposing the slip casting process to a strong magnetic field followed by the traditional processing for translucent alumina ceramics. X‐ray diffraction and orthogonal polarizing microscopy showed that the grains have been successfully orientated in the alumina ceramics. The in‐line optical transmission is much higher than that of the randomly orientated polycrystalline alumina because the optical axes of grains are parallel to each other.
Implementation and prospective clinical validation of AI‐based planning and shimming techniques in cardiac MRI (2021)

CMR exams using EasyScan for cardiac planning demonstrated accelerated cardiac exam compared to the CMR protocol with manual cardiac planning. Improved and more uniform B0 magnetic field homogeneity also achieved using AI shim technique compared to volume shimming.
<title>Transient inversion XUV-lasers in Ti and Ge</title> (1997)

Low pump energy transient gain x-ray lasers in Ti at 32.6 nm, 30.15 nm, in V at 30.4 nm and Ge at 19.6 nm using picosecond pulse heating of a long pulse preformed plasma of neonlike ions has been realized for the first time. Gain saturation was demonstrated in Ti and Ge XRL. Results of pump consumption, x- ray divergence and output energy are given.
The CiaR Response Regulator in Group B<i>Streptococcus</i>Promotes Intracellular Survival and Resistance to Innate Immune Defenses (2008)

Group B Streptococcus (GBS) is major cause of invasive disease in newborn infants and the leading cause of neonatal meningitis. To gain access to the central nervous system (CNS), GBS must not only subvert host defenses in the bloodstream but also invade and survive within brain microvascular endothelial cells (BMEC), the principal cell layer composing the blood-brain barrier (BBB). While several GBS determinants that contribute to the invasion of BMEC have been identified, little is known about the GBS factors that are required for intracellular survival and ultimate disease progression. In this study we sought to identify these factors by screening a random GBS mutant library in an in vitro survival assay. One mutant was identified which contained a disruption in a two-component regulatory system homologous to CiaR/CiaH, which is present in other streptococcal pathogens. Deletion of the putative response regulator, ciaR, in GBS resulted in a significant decrease in intracellular survival within neutrophils, murine macrophages, and human BMEC, which was linked to increased susceptibility to killing by antimicrobial peptides, lysozyme, and reactive oxygen species. Furthermore, competition experiments with mice showed that wild-type GBS had a significant survival advantage over the GBS DeltaciaR mutant in the bloodstream and brain. Microarray analysis comparing gene expression between wild-type and DeltaciaR mutant GBS bacteria revealed several CiaR-regulated genes that may contribute to stress tolerance and the subversion of host defenses by GBS. Our results identify the GBS CiaR response regulator as a crucial factor in GBS intracellular survival and invasive disease pathogenesis.
HYPOTHALAMIC HYPOPITUITARISM FOLLOWING CRANIAL IRRADIATION FOR NASOPHARYNGEAL CARCINOMA (1986)

Eight patients, one male and seven females, with no pre-existing hypothalamic-pituitary disease, who developed symptoms of hypopituitarism following cranial irradiation for nasopharyngeal carcinoma were studied 5 years or more after radiotherapy. All were GH deficient. Four of the patients with no GH response during insulin tolerance tests (ITT) showed increased GH in response to synthetic human growth hormone releasing factor (GRF-44). Four patients had impaired cortisol responses to ITT, and gradual but diminished cortisol responses to ovine corticotrophin releasing factor (CRF-41). There was no significant difference between mean peak increments in response to ITT and those in response to CRF-41. TSH responses to TRH were delayed in five and absent in two patients; four of these had low free T4 index. Prolactin was raised in all seven women and increased further in response to TRH. Two patients had impaired gonadotrophin responses to LHRH. None of the patients had clinical or biochemical evidence of diabetes insipidus. These data suggest that post-irradiation hypopituitarism in these patients results from radiation damage to the hypothalamus leading to varying degrees of deficiency of the hypothalamic releasing or inhibitory factors.
Osteocyte calcium signals encode strain magnitude and loading frequency in vivo (2017)

Osteocytes are considered to be the major mechanosensory cells of bone, but how osteocytes in vivo process, perceive, and respond to mechanical loading remains poorly understood. Intracellular calcium (Ca<sup>2+</sup>) signaling resulting from mechanical stimulation has been widely studied in osteocytes in vitro and in bone explants, but has yet to be examined in vivo. This is achieved herein by using a three-point bending device which is capable of delivering well-defined mechanical loads to metatarsal bones of living mice while simultaneously monitoring the intracellular Ca<sup>2+</sup> responses of individual osteocytes by using a genetically encoded fluorescent Ca<sup>2+</sup> indicator. Osteocyte responses are imaged by using multiphoton fluorescence microscopy. We investigated the in vivo responses of osteocytes to strains ranging from 250 to 3,000 [Formula: see text] and frequencies from 0.5 to 2 Hz, which are characteristic of physiological conditions reported for bone. At all loading frequencies examined, the number of responding osteocytes increased strongly with applied strain magnitude. However, Ca<sup>2+</sup> intensity within responding osteocytes did not change significantly with physiological loading magnitudes. Our studies offer a glimpse into how these critical bone cells respond to mechanical load in vivo, as well as provide a technique to determine how the cells encode magnitude and frequency of loading.
ChemInform Abstract: Improved Preparation and Synthetic Uses of 3‐Deoxy‐D‐arabino‐hexonolactone (IV): An Efficient Synthesis of Leptosphaerin (V). (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Two-Stage Stochastic Programming Model for Market Clearing With Contingencies (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Planning for contingencies typically results in the use of more expensive facilities before disruptions. It leads to different prices and energy availability at various network locations depending on how the contingency analysis is performed. In this paper we present a two-stage stochastic programming model for incorporating contingencies. The model is computationally demanding, and made tractable by using an interior-point log-barrier method coupled with Benders decomposition. The second-stage optimal recourse function (RF) defines the most economically efficient actions in the post-contingency state for returning the system back to normal operating conditions. The approach is illustrated with for two examples: small (with 8 buses/11 branches) and IEEE medium-scale (with 300 buses/411 branches). </para>