gebhart/patrepeval huggingface dataset:
Aspirin Use, Tumor<i>PIK3CA</i>Mutation, and Colorectal-Cancer Survival (2012)

Regular use of aspirin after diagnosis was associated with longer survival among patients with mutated-PIK3CA colorectal cancer, but not among patients with wild-type PIK3CA cancer. The findings from this molecular pathological epidemiology study suggest that the PIK3CA mutation in colorectal cancer may serve as a predictive molecular biomarker for adjuvant aspirin therapy. (Funded by The National Institutes of Health and others.).
Vinyl Derivatives of the Metals. I. Synthesis of Vinyltin Compounds (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVinyl Derivatives of the Metals. I. Synthesis of Vinyltin CompoundsDietmar Seyferth and F. G. A. StoneCite this: J. Am. Chem. Soc. 1957, 79, 3, 515–517Publication Date (Print):February 1, 1957Publication History Published online1 May 2002Published inissue 1 February 1957https://pubs.acs.org/doi/10.1021/ja01560a003https://doi.org/10.1021/ja01560a003research-articleACS PublicationsRequest reuse permissionsArticle Views1392Altmetric-Citations144LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deregulation of the Cell Cycle Machinery by Epstein–Barr Virus Nuclear Antigen 3C (2008)

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with a large number of lymphoid and epithelial malignancies. As a successful pathogen it has co-evolved with its human host for millions of years. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, a small subset of viral proteins is expressed. These proteins are essential for maintenance of the EBV genome as well as the deregulation of various signaling pathways that facilitate the proliferation and survival of the infected cells. Epstein-Barr nuclear antigen (EBNA)3C is one of the latent proteins shown to be essential for transformation of primary human B lymphocytes <i>in vitro</i>. EBNA3C primarily functions as a transcriptional regulator by interacting with a number of well known cellular and viral transcriptional factors. We have recently identified several binding partners for EBNA3C including proteins that regulate cell cycle and chromatin remodeling. We are actively engaged in discerning the biological significance of these interactions. This review summarizes our current understanding of how EBNA3C usurps cellular pathways that promote B-cell transformation.
Ni-co alloys electrodeposited in stainless steel for supercapacitors electrodes (2013)

The development of electric energy storage devices with high power density has become one of the most challenging research areas in a wide range of applications. In this context, electrochemical supercapacitors are attracting great attention due to their high potential density, fast charge-discharge cycles and high number of life cycles. In the present work, Ni-Co nanostructured films were produced by electrodeposition technique in order to form a porous dendritic structure with enhanced surface area. The electrochemical behaviour of the deposited films was studied by charge-discharge experiments. The Ni-Co dendritic films electrodeposited at current densities i1 = -4 mA cm-2 and i2 = -30 mA cm-2 display a specific capacitance of 215 F g-1. The capacitance loss is about 33 % after 6000 charge-discharge cycles.
Growth Response of Avena sativa in Amino-Acids-Rich Soils Converted from Phenol-Contaminated Soils by Corynebacterium glutamicum (2012)

The biodegradation of phenol in laboratory-contaminated soil was investigated using the Gram-positive soil bacterium Corynebacterium glutamicum. This study showed that the phenol degradation caused by C. glutamicum was greatly enhanced by the addition of 1% yeast extract. From the toxicity test using Daphnia magna, the soil did not exhibit any hazardous effects after the phenol was removed using C. glutamicum. Additionally, the treatment of the phenolcontaminated soils with C. glutamicum increased various soil amino acid compositions, such as glycine, threonine, isoleucine, alanine, valine, leucine, tyrosine, and phenylalanine. This phenomenon induced an increase in the seed germination rate and the root elongation of Avena sativa (oat). This probably reflects that increased soil amino acid composition due to C. glutamicum treatment strengthens the plant roots. Therefore, the phenol-contaminated soil was effectively converted through increased soil amino acid composition, and additionally, the phenol in the soil environment was biodegraded by C. glutamicum.
An Antiplatelet Aggregation Principle and X-Ray Structural Analysis of cis-Khellactone Diester from Peucedanum japonicum (1992)

Three structurally related khellactone coumarins, 1-3, were isolated from the aerial parts of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3'-isovaleryl-4'-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3',4'-disenecioylkhellactone [3] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3',4'-diisovalerylkhellactone [1] showed significant activity (at 50 micrograms/ml).
Classification of Dishes to Create a Balanced Diet (2003)

食事状況を「料理の組合せ方からみた食べ方」で的確に分かりやすく示すために, 飲食物 (料理) を内容と量, 調理形態から期待される栄養的価値と嗜好的意義に基づき, 主食・主菜・副菜・小菜・汁・デザート・飲物・酒に分類する方法を明らかにした。分類の指標と基準はできるだけ簡便で分かりやすく, 摂取量の目安となるような汎用性があるものとし, 機械的処理により再現性を高くした。この分類方法を用いれば, 対象集団の料理の組合せからみた食べ方を定量化して示すことができ, 複数個人の集まりとしての集団レベルの食事摂取状況の評価にも役立つことを, 中年主婦71人, 842日分の食事記録調査データを用いて確認した。なお, 上記データの4,238食分, 延べ14,708品目の料理は, 主食17.1%, 主菜13.3%, 副菜13.5%, 小菜14.3%, 汁6.8%, デザート9.8%, 飲物24.1%, 酒1.1%に分類された。また, 主食・主菜・副菜の1食当たり平均摂取単位は0.94・1.03・0.97で, これらを1単位ずつ摂取した場合の合計が711kcalであったことなどから, 設定した1単位量が摂取目安量として妥当であること, 主食・主菜・副菜を組み合わせることにより, 食事摂取基準値をほぼ充足できることを明らかにした。
Financial impact of oral vinorelbine use in a regional hospital (2012)

<h3>Background</h3> The advantages of orally active chemotherapy make it a valuable option for treating cancer patients. <h3>Purpose</h3> To assess the use and cost of oral vinorelbine (OV) in a regional hospital. <h3>Materials and methods</h3> A retrospective descriptive study carried out from January 2009 till September 2010. The authors report on all the patients who were treated with OV during the period of study. The authors checked the following information: sex, age, diagnosis, previous and subsequent chemotherapy regimens, chemotherapy regimen, mean dose, patient-related cost and overall cost. <h3>Results</h3> The authors studied 21 patients (80.9% men and 19.1% women) with a mean age of 68.1±8.9 years. 15 patients were diagnosed with non-small cell lung cancer (NSCLC), 3 with breast cancer (BC) and 3 with prostate cancer (PC). 40% of patients with NSCLC had previously been treated with cisplatin-paclitaxel or cisplatin-gemcitabine whereas 60% had been treated with cisplatin-vinorelbine or vinorelbine alone. With regard to the other diagnoses: 3 patients with BC had been treated with paclitaxel-anthracycline and 3 patients with PC had been treated with paclitaxel-carboplatin. For the current treatment, the distribution of treatments was the following: a) OV monotherapy (6), b) OV associated with cisplatin (6), c) docetaxel monotherapy (2) and c) without treatment (7). The chemotherapy regimens with OV were: 60 mg/m2, on the 1st and 8th day every 21 days (71.4%); 60 mg/m2, on the 1st and 8th day every 21 days the first cycle and 80 mg/m2, on the 1st and 8th day every 21 days in the following cycles (14.3%); 60 mg/m2, on days 1, 8 and 15 every 28 days (14.3%). Average dose of OV was 110.4±13.6 mg with an average number of prescriptions dispensed of 4.7±2.7. Only 9 patients had received prior intravenous vinorelbine. Patient-related cost was 1,314.08 € and overall cost was 14,454.96 €. <h3>Conclusions</h3> In our hospital, OV was used in accordance with the guidelines except that the absence of intravenous vinorelbine first in 42.8% of patients should be justified. Although the cost of OV is high it is justifiable because it avoids indirect costs.
Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes (2008)

Bile acids (BAs) are natural ligands of nuclear receptors, in particular farnesoid X receptor (FXR). Whether, in addition to protein-mediated cytosolic-nuclear BA translocation, other mechanisms are involved in the access of BAs to nuclear FXR was investigated. When rat hepatocytes were incubated with radiolabeled taurocholic acid, taurodeoxycholic acid, taurochenodeoxycholic acid, and tauroursodeoxycholic acid, their nuclear accumulation was proportional to their intracellular levels. With the use of flow cytometry analysis, the accumulation by nuclei isolated from rat liver cells was found to differ for several fluorescent compounds of similar molecular weight and different charge, including fluorescein-tagged BAs [cholylglycyl amidofluorescein (CGamF), ursodeoxycholylglycyl amidofluorescein, or chenodeoxycholylglycyl amidofluorescein]. When we varied nuclear volume by incubation with different sucrose concentrations, a similar relationship between nuclear volume and content of FITC and 4-kDa FITC-dextran was found. In contrast, this relationship was markedly lower for CGamF. Confocal microscopy studies revealed that fluorescein-tagged BAs, but also FITC or 10-kDa FITC-dextran were found in the nuclear envelope and concentrated in regions where DNA was less densely packed. In contrast to the cytosolic subcellular localization of peroxisome proliferator-activated receptor-alpha, FXR and nucleolin (a marker of transcriptional active chromatin) were also localized by immunoreactivity in these intranuclear regions. In conclusion, although intranuclear levels of small organic molecules including conjugated BAs depend on their concentrations in the extranuclear space, the existence of certain molecular selectivity (not strictly dependent on molecular weight or charge) suggests that, in addition to simple diffusional exchange, other mechanisms may be also involved in determining their overall nuclear content in regions where these compounds coincide and may interact with nuclear receptors such as FXR.
A Standardized Nomenclature for Latissimus Dorsi Cardiomyoplasty (1991)

As worldwide clinical and experimental data accumulate, a standardized nomenclature for latissimus dorsi cardiomyoplasty must be accepted and universally applied in order to increase the potential for meaningful and reproducible comparison of results. This article presents a uniform nomenclature for latissimus dorsi cardiomyoplasty that is precise, anatomic and complete.
Cyclopolymerization of α,Ω-Diepoxide with Monoepoxy Comonomer. Synthesis and Cation-Binding Property of Copolymers with Dibenzo-19-Crown-6 Units (1994)

Abstract Cyclocopolymerizations of 5,6-benzo-l,2:9,10-diepoxy-4,7-dioxa-deca-5-ene (BDD) and monoepoxy comonomers, propylene oxide (PO), epichlorohydrin (ECH), and phenyl glycidyl ether (PGE), were carried out with SnCl4 to form gel-free copolymers with no residual epoxy groups. The copolymerization parameters were r, = 1.09 and r2 = 0.86 for BDD (M1)-PGE (M2). In addition, 5, 6:14,15-dibenzo-l,2:18,19-diepoxy-4,7,-10,13,16-pentaoxanonadeca-5,14-diene (DDP) with PO, ECH, or PGE were copolymerized with SnCl4 in CH2C12 and with KOH in DMSO to form copolymers with dibenzo-19-crown-6 units. Poly[(dibenzo-19-crown-6)-co-PO] and poly[(dibenzo-19-crown-6)-co-PGE] showed lower extracting yields for alkali-metal picrates than did the homopolymer of DDP, poly(dibenzo-19-crown-6). However, poly[(dibenzo-19-crown-6)-co-PGE] exhibited a higher selectivity for K+ than did the other polymers.
Component ontological representation of function for diagnosis (2002)

Using function instead of fault probabilities for candidate discrimination during model based diagnosis has the advantages that function is more readily available, and facilitates explanation generation. However, current representations of function have been context dependent and state based, making them inefficient and time consuming. We propose classes as a scheme of representation of function for diagnosis based on component ontology principles, i.e., we define component functions (called classes) with respect to their ports. The scheme is space and time-wise linear in complexity, and hence, efficient. It is also domain-independent and scalable to representation of complex devices. We demonstrate the utility of the representation for the diagnosis of a printer buffer board.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Methanolysis of Fucoidan. II. The Presence of Sugars Other Than L-Fucose (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethanolysis of Fucoidan. II. The Presence of Sugars Other Than L-FucoseRichard G. SchweigerCite this: J. Org. Chem. 1962, 27, 12, 4270–4272Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/jo01059a034https://doi.org/10.1021/jo01059a034research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-Power Operation of AlGaAs/GaAs Large-Optical-Cavity Laser Diode with ZnS<sub><i>x</i></sub>Se<sub>1-<i>x</i></sub> (<i>x</i>=0.06) Layer Grown by Adduct-Source Metalorganic Chemical Vapor Deposition Method (1989)

High-power operation of a large-optical-cavity (LOC) AlGaAs laser diode with a ridge waveguide buried in a ZnSxSe1-x (x=0.06) layer has been achieved. In order to produce a reliable high-power laser, we have developed the growth of a lattice-matched ZnSxSe1-x (x=0.06) layer by adduct-source metalorganic chemical vapor deposition (MOCVD) and a self-aligned fabrication process by a reactive ion beam etching (RIBE) method for the etching of ZnSxSe1-x. An extremely stable transverse mode operation of up to 100 mW is obtained with a low threshold current of 30 mA at an oscillation wavelength of 780 nm.
An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model (2014)

Measles virus is a highly infectious morbillivirus responsible for major morbidity and mortality in unvaccinated humans. The related, zoonotic canine distemper virus (CDV) induces morbillivirus disease in ferrets with 100% lethality. We report an orally available, shelf-stable pan-morbillivirus inhibitor that targets the viral RNA polymerase. Prophylactic oral treatment of ferrets infected intranasally with a lethal CDV dose reduced viremia and prolonged survival. Ferrets infected with the same dose of virus that received post-infection treatment at the onset of viremia showed low-grade viral loads, remained asymptomatic, and recovered from infection, whereas control animals succumbed to the disease. Animals that recovered also mounted a robust immune response and were protected against rechallenge with a lethal CDV dose. Drug-resistant viral recombinants were generated and found to be attenuated and transmission-impaired compared to the genetic parent virus. These findings may pioneer a path toward an effective morbillivirus therapy that could aid measles eradication by synergizing with vaccination to close gaps in herd immunity due to vaccine refusal.
Multiple effects of Wnt3a on lymphoid progenitors and their environment (83.4) (2007)

Abstract The Wnt family of secreted glycoproteins has been implicated in many aspects of development, but its contribution to blood cell formation is poorly understood. We over-expressed Wnt3a in stromal cells of osteopetrotic mice and used them in co-culture experiments with highly enriched stem and progenitor cells. The objective was to learn if and how particular stages of B lymphopoiesis are responsive to this canonical Wnt ligand. We found that functional receptors were present on all populations tested, and that Wnt signaling generally inhibited B lineage progression. However, this effect was less in long term cultures. Other results suggest that lineage instability results from Wnt signaling and there was even evidence for loss of differentiation. That is, RAG1+ cells down-regulated expression of this gene and acquired some characteristics of stem cells. At the same time, short term exposure to Wnt3a increased myeloid colony forming potential and retained the ability of progenitors to be transplanted. We also found a surprising effect on expression of cell adhesion molecules thought to retain cells in the bone marrow. VCAM-1 on stromal cells, stem cells or an endothelial cell line was dramatically down-regulated when the cells were exposed to Wnt3a. We conclude that in addition to effects on differentiation, canonical Wnt signaling may control positioning of stem and progenitor cells within the bone marrow.
THE MICROWAVE SPECTRUM AND CONFORMATION OF METHOXY $OZONIDE (H_{3}COCHOOCH_{2}O)$ (1986)

Address of LaBarge and Kuczkowski: Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109. Address of Keul: Lehrstuhl f\""{u}r Textilchemie und Makromoleculare Chemie, der RWTH, Aachen, West Germany.
Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: Significant role of Asn ladder (2005)

Recent evidence suggests that amyloidogenic oligomers may be the toxic species in cell cultures. Thus, it is crucial to understand their structure and oligomerization mechanism in atomistic detail. By employing tens of fast central processing units and an advanced phase-space sampling algorithm, parallel-tempering molecular dynamics, we have explored the energy landscape of amyloidogenic peptide oligomerization in explicit water. A pentapeptide, DFNKF, derived from human calcitonin and its mutant, DFAKF, was simulated with a total simulation time of approximately 500 ns. The detailed oligomerization process of a DFNKF parallel beta-sheet formation at 300 K has been characterized. The assembly of a parallel beta-sheet from the amorphous state mainly occurs via a "bottleneck" channel where the interstrand Asn-Asn stacking is the major interaction. The interactions of Asn-Asn stacking include both backbone and side-chain hydrogen bonds. The Asn-Asn interactions work like "glue" by sticking the DFNKF strands together and assist the "on-pathway" oligomerization. The Asn-Asn stacking observed here is similar to the Asn ladder commonly found in globular beta-helix proteins. A control run shows that when Asn is mutated to Ala, the stability and population of the DFAKF parallel beta-sheet is decreased. Furthermore, our in vitro mutagenesis experiments show that the ability of DFAKF peptides to form amyloid fibrils is significantly reduced, in agreement with the simulations. Knowledge of the energy landscape of oligomerization may provide hints for rational drug design, preventing amyloid-associated diseases.
Monoids for rapid data flow analysis (1978)

The earliest data flow analysis research dealt with concrete problems (such as detection of available expressions) and with low level representations of control flow (with one large graph, each of whose nodes represents a basic block). Several recent papers have introduced an abstract approach, dealing with any problem expressible in terms of a semilattice L and a monoid M of isotone maps from L to L, under various algebraic constraints. Examples include [CC77; GW76; KU76; Ki73; Ta75; Ta76; We75]. Several other recent papers have introduced a high level representation with many small graphs, each of which represents a small portion of the control flow information in a program. The hierarchy of small graphs is explicit in [Ro77a; Ro77b] and implicit in papers that deal with syntax directed analysis of programs written within the confines of classical structured programming [DDH72, Sec. 1.7]. Examples include [TK76; ZB74]. The abstract papers have retained the low level representations while the high level papers have retained the concrete problems of the earliest work. This paper studies abstract conditions on L and M that lead to rapid data flow analysis, with emphasis on high level representations. Unlike some analysis methods oriented toward structured programming [TK76; Wu75; ZB74], our method retains the ability to cope with arbitrary escape and jump statements while it exploits the control flow information implicit in the parse tree.
Détermination du degré d'association des cations monovalents avec les carboxyméthylcelluloses (1971)

L'objet de ce travail est une discussion des valeurs théo-riques du coefficient d'activité par rapport aux valeurs expé- rimentales obtenues par potentiométrie. On adopte un modèle de polyion en cylindre; le potentiel électrostatique est calculé en fonction de la distance à l'axe et pour des polyélectrolytcs à densité de charge variable (λ = 1,7 à 4,11). On décrit la distribution des ions compensateurs au voisinage du polyion, et on donne l'expression analytique de ά(r) = f(r/a) qui permet de. calculer la fraction d'ions libres ά1 pour lesquels εΔψ/kT ≤ 1 et ά2, pour lesquels εΔψ/kT ≤ 2. Ces valeurs sont comparées à (D/D0), coefficient de diffusion libre des cations compensateurs et aux coefficients osmotiques donnés par les théories récentes sur les polyélectrolytcs.