gebhart/patrepeval huggingface dataset:
External Morphology of the Posterior End, the “Opisthosoma”, of the Beard Worm Oligobrachia mashikoi (Pogonophora) (2003)

The entire length of the beard worm, Oligobrachia mashikoi (Pogonophora), including the posterior end, the "opisthosoma" was collected successfully. This species is exclusive to Tsukumo Bay in Ishikawa Prefecture, Japan. Although the portion preceding the opisthosoma was similar to a fine filament, it abruptly assumed a shape similar to a shovel and appeared to be composed of many segmental structures. The number of segments exceeded 50. The dorsal side of the opisthosoma differed from that of the ventral side in morphology. The opisthosoma was equipped with 4 lines of setae arranged longitudinally and a sucker on the tip. When considering the fact that the Family Oligobrachiidae is the most primitive group of pogonophores, the external morphology of the opisthosoma is interesting as it may be reminiscent of the ancestral condition. This is the first report of the opisthosoma in Oligobrachiidae.
Modeling multi-threaded architectures in PAMELA for real-time high performance applications (2002)

Presents a method to explore the design space of multi-threaded architectures using PAMELA (PerformAnce ModEling LAnguage). The domain of applications we consider is digital signal processing (DSP), where high performance is derived by exploiting both fine-grain and coarse-grain parallelism in the application. The modeling scheme takes an unified view of both fine-grain and coarse-grain parallelism in a given application to measure the performance of the architecture. The application-written using a high-level language-is compiled, and a trace generated for benchmark data in terms of the instruction set architecture of the processor. The generated trace is for a single uni-threaded, uni-processor system. This trace is pre-processed and re-targeted to generate multi-threaded architecture-specific PAMELA code. Using a material-oriented approach, the resulting PAMELA code is executed to evaluate various architecture options over the entire design space iteratively, subject to implementation constraints. We demonstrate the suitability and simplicity of the approach with an example.
161: Diabetes-Induced Increase in Detrusor Smooth Muscle Myosin Basal Phosphorylation Level is Associated with an Upregulation of Rho-Kinase and CPI-17 (2005)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 22, 2005 8:00 am - 12:00 pm1 Apr 2005161: Diabetes-Induced Increase in Detrusor Smooth Muscle Myosin Basal Phosphorylation Level is Associated with an Upregulation of Rho-Kinase and CPI-17 Shaohua Chang, Joseph A. Hypolite, Arun Changolkar, Michael E. DiSanto, Alan J. Wein, and Samuel Chacko Shaohua ChangShaohua Chang More articles by this author , Joseph A. HypoliteJoseph A. Hypolite More articles by this author , Arun ChangolkarArun Changolkar More articles by this author , Michael E. DiSantoMichael E. DiSanto More articles by this author , Alan J. WeinAlan J. Wein More articles by this author , and Samuel ChackoSamuel Chacko More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34426-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "161: Diabetes-Induced Increase in Detrusor Smooth Muscle Myosin Basal Phosphorylation Level is Associated with an Upregulation of Rho-Kinase and CPI-17." The Journal of Urology, 173(4S), p. 44 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 44 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Shaohua Chang More articles by this author Joseph A. Hypolite More articles by this author Arun Changolkar More articles by this author Michael E. DiSanto More articles by this author Alan J. Wein More articles by this author Samuel Chacko More articles by this author Expand All Advertisement PDF downloadLoading ...
A modified technique for Gore Excluder limb deployment in difficult iliac anatomy during endovascular abdominal aortic aneurysm repair (2014)

Complex iliac anatomy including extreme tortuosity constitutes a relative contraindication for endovascular abdominal aortic aneurysm repair with additional risk of limb-graft occlusion. The Gore Excluder limb-graft is a flexible stent-graft, which adapts easily to iliac tortuosity. Nevertheless, the presence of the stiff guide wire does not always allow for an ideal apposition of the stent graft to the angulated common iliac artery vessel wall. We describe herein a modified technique for Gore Excluder limb-graft deployment with partial removal of the stiff wire in cases with difficult tortuous or narrow iliac arteries during endovascular abdominal aortic aneurysm repair.
Spectral compression: Weighted principal component analysis versus weighted least squares (2014)

Two weighted compression schemes, Weighted Least Squares (wLS) and Weighted Principal Component Analysis (wPCA), are compared by considering their performance in minimizing both spectral and colorimetric errors of reconstructed reflectance spectra. A comparison is also made among seven different weighting functions incorporated into ordinary PCA/LS to give selectively more importance to the wavelengths that correspond to higher sensitivity in the human visual system. Weighted compression is performed on reflectance spectra of 3219 colored samples (including Munsell and NCS data) and spectral and colorimetric errors are calculated in terms of CIEDE2000 and root mean square errors. The results obtained indicate that wLS outperforms wPCA in weighted compression with more than three basis vectors. Weighting functions based on the diagonal of Cohen’s R matrix lead to the best reproduction of color information under both A and D65 illuminants particularly when using a low number of basis vectors.
Methods for a Randomized Trial of Weight-Supported Treadmill Training Versus Conventional Training for Walking During Inpatient Rehabilitation after Incomplete Traumatic Spinal Cord Injury (2003)

The authors describe the rationale and methodology for the first prospective, multicenter, randomized clinical trial (RCT) of a task-oriented walking intervention for subjects during early rehabilitation for an acute traumatic spinal cord injury (SCI). The experimental strategy, body weight-supported treadmill training (BWSTT), allows physical therapists to systematically train patients to walk on a treadmill at increasing speeds typical of community ambulation with increasing weight hearing. The therapists provide verbal and tactile cues to facilitate the kinematic, kinetic, and temporal features of walking. Subjects were randomly assigned to a conventional therapy program for mobility versus the same intensity and duration of a combination of BWSTT and over-ground locomotor retraining. Subjects had an incomplete SCI (American Spinal Injury Association grades B, C, and D) from C-4 to T-10 (upper motoneuron group) or from T-11 to L-3 (lower motoneuron group). Within 8 weeks of a SCI, 146 subjects were entered for 12 weeks of intervention. The 2 single-blinded primary outcome measures are the level of independence for ambulation and, for those who are able to walk, the maximal speed for walking 50 feet, tested 6 and 12 months after randomization. The trial's methodology offers a model for the feasibility of translating neuroscientific experiments into a RCT to develop evidence-based rehabilitation practices.
Thrust and electrical power from solid propellant microrockets. 2. Actuators (2002)

Progress has been made in the development of flying silicon. Fully self-contained MEMS rockets have been designed, fabricated and tested. A peak thrust of 4 mN was obtained from a rocket with a mass of 0.98 grams. This rocket was comprised of a 3.2 mm inside diameter ceramic tube bonded to a silicon chip containing the rocket nozzle, igniter and an array of twelve thermopiles. One thermopile was measured during combustion and yielded 20 micro Watts of electrical power during a combustion event of approximately 10 seconds. Third-generation devices have demonstrated liftoff.
A Novel Synthesis of α-Aminoaldehydes from Glyoxal Monoacetal (1990)

Primary and secondary amines condense with benzotriazole and glyoxal monoacetal to give N-substituted 1-(benzotriazolyl)-2,2-diethoxyethylamines 4, which with Grignard reagents readily yield the corresponding 2-aminoalkanal diethylacetal 5. These are easily hydrolyzed to produce α-aminoaldehydes 6.
Validation of a Novel Clonality Assay in Patients with Clonal Hematologic Disorders (2008)

Abstract Clonality assays, based on X-chromosome inactivation, discriminate active from inactive alleles. They are useful in the diagnosis and assessment of therapeutic response in clonal hematologic disorders, especially in absence of an identifiable somatic mutations. Skewing of X-chromosome allelic-usage, based on preferential methylation of one of the HUMARA alleles, was reported as evidence of clonal hematopoiesis in ~30% elderly women, precluding the use of this assay in elderly patient (>65 years of age). Using a quantitative, transcriptionally-based clonality assay, we did not detect clonal hematopoiesis in >200 healthy non-elderly women. In view of the susceptibility of aging hematopoietic stem cells to epigenetic dysregulation, we reinvestigated the issue of clonality in forty elderly women (age 65–92, mean 81.3 years), using a novel, quantitative qPCR transcriptional clonality assay. In this assay, mRNA transcribed from five X-chromosome polymorphic genes expressed in peripheral blood neutrophils is quantified by real time, allele specific RT-PCR. We did not detect clonal hematopoiesis in any of the elderly women. However, using HUMARA assay, 30% of these elderly women were detected to have monoallelic methylation of the HUMARA gene locus, consistent with previously reported literature. We concluded that our novel transcriptional clonality assay is suitable for evaluation of clonal hematopoiesis in all women including elderly women (Swierczek S, Agarwal N et al. Blood 2008, July 18 epub). Using this novel assay, we detected clonal hematopoiesis in 31 out of 32 well characterized patients with myeloproliferative disorders: polycythemia vera (all fourteen patients were clonal by our assay and all were JAK2V617F positive), essential thrombocytosis (nine out of ten patients were clonal by our assay, one out of ten patients was cMPLW515L positive, seven out of ten were JAK2 V617F positive; however one subject with low JAK2 V617F allelic burden was polyclonal by our assay), and primary myelofibrosis (all eight patients were clonal by our assay and two of them were positive for JAK2V617F). In addition, we detected clonal hematopoiesis in 4 patients with unexplained anemia (two eventually evolved in to myelodysplastic syndrome), and in one patient with persistent leukocytosis (eventually found to be cMPLW515L positive). Using our assay we did not detect clonal hematopoiesis in 10 patients with reactive or secondary erythrocytosis, thrombocytosis or leukocytosis. We conclude that our novel transcriptional clonality assay is suitable for detection of clonal hematopoiesis in patients with clonal hematologic disorders, especially in patients lacking known somatic mutation. Studies to detect an emerging clone in milieu of polyclonal hematopoiesis (such as seen in PNH or early stages of clonal hematological disorders) by comparison of X-chromosome allelic usage ratio in myeloid cells and in T lymphocytes are underway.
From research to routines: ultrafast laser systems can be replaced by low-cost lasers in two-photon excitation applications (2003)

This paper outlines the latest developments in two-photon excitation laboratory instrumentation using low-cost laser equipment. Our research group has shown that application of two-photon excitation need not to be limited to those laboratories that can afford the price and maintenance of ultrafast laser systems. With certain compromises and well-designed experiments, low-cost lasers, such as the Q-switched Nd:YAG microchip laser, can be used in utilizing the positive properties of two-photon excitation. Results using microparticles or cells as bioactive carriers confirm this fact. Application examples from biomedical research as well from clinical environment are presented.
ChemInform Abstract: ESTROGEN RECEPTOR BASED IMAGING AGENTS. 2. SYNTHESIS AND RECEPTOR BINDING AFFINITY OF SIDE‐CHAIN HALOGENATED HEXESTROL DERIVATIVES (1981)

Abstract Durch Behandlung von Desoxyanisoin (Ia) mit Natriumhydrid und anschließend mit Ethyliodid entsteht das Ethyldesoxyanisoin (Ib), das nach Reformatskii die diastereoisomeren Hydroxycarbonsäureester (II) ergibt.
CTHRSSVVC Peptide as a Possible Early Molecular Imaging Target for Atherosclerosis (2016)

The purpose of our work was to select phages displaying peptides capable of binding to vascular markers present in human atheroma, and validate their capacity to target the vascular markers in vitro and in low-density lipoprotein receptor knockout (LDLr(-/-)) mouse model of atherosclerosis. By peptide fingerprinting on human atherosclerotic tissues, we selected and isolated four different peptides sequences, which bind to atherosclerotic lesions and share significant similarity to known human proteins with prominent roles in atherosclerosis. The CTHRSSVVC-phage peptide displayed the strongest reactivity with human carotid atherosclerotic lesions (p < 0.05), when compared to tissues from normal carotid arteries. This peptide sequence shares similarity to a sequence present in the fifth scavenger receptor cysteine-rich (SRCR) domain of CD163, which appeared to bind to CD163, and subsequently, was internalized by macrophages. Moreover, the CTHRSSVVC-phage targets atherosclerotic lesions of a low-density lipoprotein receptor knockout (LDLr(-/-)) mouse model of atherosclerosis in vivo to High-Fat diet group versus Control group. Tetraazacyclododecane-1,4,7,10-tetraacetic acid-CTHRSSVVC peptide (DOTA-CTHRSSVVC) was synthesized and labeled with (111)InCl₃ in >95% yield as determined by high performance liquid chromatography (HPLC), to validate the binding of the peptide in atherosclerotic plaque specimens. The results supported our hypothesis that CTHRSSVVC peptide has a remarkable sequence for the development of theranostics approaches in the treatment of atherosclerosis and other diseases.
Analysis of a mod B Mutant in Dictyostelium discoideum Using mRNA Differential Display (2000)

Three differential cDNAs of Dictyostelium, not detected in the mod B mutant defective in O-glycosylation, were isolated by using an mRNA differential display. These cDNAs encode a protein tyrosine kinase, an adenylyl cyclase and a putative protein kinase C inhibitor whose expression is developmentally regulated.
Hall sensor array for measuring displacement of a 2D magnet array (2013)

There are numerous cases where sensing signal is corrupted by harmonic components or a desired harmonic component is hidden in other harmonic signals. Therefore, various studies have been done in filtering or estimation algorithm to filter or extract harmonic signal. This paper presents sensor array for filtering of harmonic signals. First, 1D sensor array is introduced to filter n harmonic components. Then, 1D array is extended to 2D sensor array to filter out 2D harmonic signals. Finally, hall sensor array is built to measure displacement of a 2D magnet array and its performance is verified with experiments.
Preparation of Lateral Isolation Structures by Controlling Bi or Ca Compositions in Bi-System Superconducting Films (1991)

Two kinds of monolithic lateral isolation structures have been obtained by controlling Bi or Ca compositions in the lateral direction using a Bi-oxide system for the first time. One is a BiSrCaCuO/SrCaCuO/BiSrCaCuO structure, which was made from a Bi-O/SrCaCuO layer. The other is a BiSrCaCuO/BiSrCuO/BiSrCaCuO structure, which was made from a Ca-F/BiSrCuO layer. Each BiSrCaCuO area is composed of a 2-2-1-2 phase and a 2-2-2-3 phase, with high crystallinity in the c-axis orientation. A SrCaCuO area indicates semi-insulation. The BiSrCuO area showed a flat temperature dependence of resistivity above 25 K and exhibited a resistivity of about 6 mΩ·cm.
Comparing Downlink Coordinated Multi-Point Schemes with Imperfect Channel Knowledge (2011)

Several linear transmit precoding and receive combining strategies with and without base station cooperation are compared to each other. The impact on sum-rate performance is shown with varying number of transmit and receive antennas, with different amounts of training and with varying receive power levels of the cooperating set. This is done by simulations in a two-user two-cell scenario. The limited scenario size helps to carve out the crucial parameters and show their interrelation with imperfect channel knowledge (CSI). These CSI imperfections are emulated based on a novel model, introduced in this paper. We show that imperfect CSI drastically reduces the relative coordinated multi-point (CoMP) gains over non-coordinated systems. The non-coordinated systems can already perform quite well, when multi-antenna terminals apply interference suppression strategies. Our results motivate that CoMP systems need to be studied under critical system assumptions, taking into account non-idealities, as they have a severe impact on the observed gains.
A Population Pharmacokinetic Model of Cyclosporine in the Early Postoperative Phase in Patients With Liver Transplants, and Its Predictive Performance With Bayesian Fitting (1998)

The availability of personal computer programs to individualize drug regimens has stimulated interest in modeling population pharmacokinetics. This study used the NPEM2 software to determine cyclosporine population pharmacokinetic parameter values and distributions in a first group of 25 recipients of liver transplants during their first postoperative week. On a second group of 25 patients, the authors used these values to evaluate Bayesian predictive performance of cyclosporine blood concentrations with the USC*PACK PC program. During the study period, all the patients have been treated by continuous intravenous infusion. The one-compartment model pharmacokinetic parameter-the slope of volume to body weight (Vs) and the elimination rate constant (Kel) values found (mean values: Vs = 2.177 l/kg, Kel = 0.235 h(-1); median values: Vs = 1.559 l/kg, Kel = 0.163 h(-1); the percent coefficient of variation (Vs = 92%, Kel = 79%) appear reasonable and show the ability of NPEM2 to deal with sparse data. When the predictions were studied with day 1, day 2, or day 3 concentrations, predictive bias was respectively -0.030, -0.013, and 0.013 microg/ml, suggesting a greater clearance of cyclosporine immediately after surgery, the clearance decreasing in the days after. With the first three blood levels and the Bayesian fitting procedure, it was possible to predict at least half the subsequent measured blood levels of each patient accurately (within 20%) in more than three-quarters (76%) of the second group of recipients of transplants, and for 40% of patients the authors obtained accurate predictions in 100% of the subsequent blood levels. For a few patients (12%) they found quite poor predictions. The reason for this is unclear. The results suggest that this population model and the Bayesian fitting procedure using two or three blood levels can be reasonably and carefully used to control, in real time, cyclosporine blood levels in a majority of new patients with liver transplants.
Boosting Anti‐idiotype Immune Response with Recombinant AAV Enhances Tumour Protection Induced by Gene Gun Vaccination (2008)

Thanks to the safety of administration, efficiency of in vivo transduction and persistence of transgene expression, vectors based on the adeno-associated virus (AAV) are extensively utilized in both preclinical and clinical experimentation. Here we thoroughly explore the potential of AAV-mediated antigen delivery for tumour vaccination. A recombinant AAV vector (rAAV) encoding a lymphoma idiotype (Id) in a single-chain variable fragment format was found to induce an efficient anti-Id immune response upon injection in immunocompetent animals. The intensity of the immune response and the protective effect of rAAV administration in vivo were systematically compared with those elicited by simple injection of naked DNA or biolistic immunization. The results indicate that Id delivery via rAAV enhances the intensity of immune response compared with injection of naked DNA, while anti-idiotypic antibodies titres are not considerably increased compared with biolistic vaccination. On the contrary, a prime-boost vaccination strategy combining biolistic and AAV DNA delivery results in a major increase in anti-Id antibody response compared with the repetitive biolistic immunization. This increased anti-Id humoral response strictly correlated with a significant improvement on tumour protection in vivo.
The in vitro synthesis and processing of the branched‐chain amino acid binding proteins (1980)

The synthesis of the leucine-specific and LIV-binding proteins was examined in vitro in a coupled transcription/translation system using the hybrid plasmids pOX7 and pOX13 as templates. Plasmid pOX7 contains the livK gene coding for the leucine-specific binding protein and pOX13 contains the livJ gene coding for the LIV-binding protein. Both binding proteins were synthesized in vitro as precursor forms with molecular weights approximately 2,500 greater than their respective mature forms. Conversion of the precursor forms to their mature forms occurred during post-translational incubation following synthesis in the presence of membrane. The precursor of the LIV-binding protein was processed more rapidly than the leucine-specific binding protein precursor. Processing activity could be removed from the in vitro synthesis system by centrifugation, suggesting that the processing activity was membrane associated. Restoration of post-translational processing activity was achieved by adding inside-out membrane vesicles to membrane-depleted reaction mixtures.
Chemotherapy Enhances Metastasis Formation via VEGFR-1–Expressing Endothelial Cells (2011)

Recent studies suggest that chemotherapy, in addition to its cytotoxic effects on tumor cells, can induce a cascade of host events to support tumor growth and spread. Here, we used an experimental pulmonary metastasis model to investigate the role of this host response in metastasis formation. Mice were pretreated with chemotherapy and after clearance of the drugs from circulation, tumor cells were administered intravenously to study potential "protumorigenic" host effects of chemotherapy. Pretreatment with the commonly used chemotherapeutic agents cisplatin and paclitaxel significantly enhanced lung metastasis in this model. This corresponded to enhanced adhesion of tumor cells to an endothelial cell monolayer that had been pretreated with chemotherapy in vitro. Interestingly, chemotherapy exposure enhanced the expression of VEGF receptor 1 (VEGFR-1) on endothelial cells both in vitro and in vivo. Administration of antibodies targeting VEGFR-1 reversed the early retention of tumor cells in the lungs, thereby preventing the formation of chemotherapy-induced pulmonary metastases. The data indicate that chemotherapy-induced expression of VEGFR-1 on endothelial cells can create an environment favorable to tumor cell homing. Inhibition of VEGFR-1 function may therefore be used to counteract chemotherapy-induced retention of tumor cells within the metastatic niche, providing a novel level of tumor control in chemotherapy.