gebhart/patrepeval huggingface dataset:
CD28− and CD28lowCD8+ Regulatory T Cells: Of Mice and Men (2017)

Since the rebirth of regulatory (formerly known as suppressor) T cells in the early 1990s, research in the field of immune-regulation by various T cell populations has quickly gained momentum. While T cells expressing the transcription factor Foxp3 are currently in the spotlight, several other T cell populations endowed with potent immunomodulatory capacities have been identified in both the CD8<sup>+</sup> and CD4<sup>+</sup> compartment. The fundamental difference between CD4<sup>+</sup> and CD8<sup>+</sup> T cells in terms of antigen recognition suggests non-redundant, and perhaps complementary, functions of regulatory CD4<sup>+</sup> and CD8<sup>+</sup> T cells in immunoregulation. This emphasizes the importance and necessity of continuous research on both subpopulations of regulatory T cells (Tregs) so as to decipher their complex physiological relevance and possible synergy. Two distinct CD8-expressing Treg populations can be distinguished based on expression of the co-stimulatory receptor CD28. Here, we review the literature on these (at least in part) thymus-derived CD28<sup>low</sup> and peripherally induced CD28<sup>-</sup>CD8<sup>+</sup> Tregs.
Molecular characterization of the type-specific gamma-determinant located on the adenovirus fiber (1997)

The fiber knob carries the type-specific gamma-antigen which can be demonstrated in hemagglutination inhibition tests. In order to characterize the gamma-determinant we selected subgenus DI adenovirus serotypes 9 and 19 (Ad9 and Ad19) which exhibited 29 amino acid exchanges in the knob domain. Like all subgenus DI adenoviruses they showed a complete hemagglutination pattern with rat and human erythrocytes. We constructed a total of 14 chimeric Ad9/Ad19 and Ad19/Ad9 fiber proteins, which possessed fiber knobs with progressively exchanged Ad9 and Ad19 amino acids. Furthermore, we created 39 fiber proteins with distinct amino acid exchanges in the knob regions by primer-directed mutagenesis. The proteins were expressed in Escherichia coli and tested in hemagglutination and hemagglutination inhibition tests. From our results we can conclude that the type-specific gamma-determinant is not restricted to a distinct region on the adenovirus fiber knob but is composed of at least 17 amino acids. Most of the amino acids contributing to the Ad9 and Ad19 gamma-determinants are located on the fiber knob loops.
Steeds minder dioxinen, furanen en dioxineachtige PCB's in de voeding (2003)

Ondanks de steeds verder dalende dioxine- en PCB-gehalten in voedingsmiddelen verdienen deze stoffen ook in de toekomst blijvende aandacht. Dit geldt zeker voor PCB-gehalten in vis
Undo as concurrent inverse in group editors (2002)

As an important mechanism for error recovery and exploration of alternatives in interactive and collaborative applications, an undo facility should have the capability of undoing any operation at any time. However, supporting undo in collaborative applications is technically challenging and none of the existing group undo solutions is able to offer such a capability. In this article, we contribute an undo solution with such a capability for group text editors. The basic idea is to interpret an undo command as a concurrent inverse operation by means of operational transformation. To cope with the high complexity of group undo, a generic undo framework has been adopted to separate undo policy from the undo mechanism and to separate transformation control algorithms from transformation functions. The proposed undo solution consists of a generic transformation control algorithm that is capable of generating, transforming, and representing valid inverse operations in any context, and a set of transformation functions that are capable of preserving undo-related transformation conditions and properties. Formal proofs are provided to show the correctness of the undo transformation control algorithm in achieving the required undo effect, undo property, and consistency properties. Solutions to the known undo puzzles are provided to show soundness of the transformation functions. A Web-based group text editor REDUCE (REal-time Distributed Unconstrained Cooperative Editing) has been implemented to demonstrate the feasibility and usability of the proposed undo and other technical solutions. The proposed undo solution is generally applicable to collaborative applications that support concurrent insertion and deletion on shared documents consisting of one or multiple dimensions of linearly ordered data objects with positional references.
DenseRaC: Joint 3D Pose and Shape Estimation by Dense Render-and-Compare (2019)

We present DenseRaC, a novel end-to-end framework for jointly estimating 3D human pose and body shape from a monocular RGB image. Our two-step framework takes the body pixel-to-surface correspondence map (i.e., IUV map) as proxy representation and then performs estimation of parameterized human pose and shape. Specifically, given an estimated IUV map, we develop a deep neural network optimizing 3D body reconstruction losses and further integrating a render-and-compare scheme to minimize differences between the input and the rendered output, i.e., dense body landmarks, body part masks, and adversarial priors. To boost learning, we further construct a large-scale synthetic dataset (MOCA) utilizing web-crawled Mocap sequences, 3D scans and animations. The generated data covers diversified camera views, human actions and body shapes, and is paired with full ground truth. Our model jointly learns to represent the 3D human body from hybrid datasets, mitigating the problem of unpaired training data. Our experiments show that DenseRaC obtains superior performance against state of the art on public benchmarks of various humanrelated tasks.
Detection and Positioning of Pipes and Columns with Autonomous Multicopter Drones (2018)

A multimodal sensory array to accurately position aerial multicopter drones with respect to pipes has been studied, and a solution exploiting both LiDAR and vision sensors has been proposed. Several challenges, including detection of pipes and other cylindrical elements in sensor space and validation of the elements detected, have been studied. A probabilistic parametric method has been applied to segment and position cylinders with LIDAR, while several vision-based techniques have been tested to find the contours of the pipe, combined with conic estimation cylinder pose recovery. Multiple solutions have been studied and analyzed, evaluating their results. This allowed proposing an approach that combines both LiDAR and vision to produce robust and accurate pipe detection. This combined solution is validated with real experimental data.
Secretin-Induced Bile Secretion, Bile Acid Output and Blood Supply to the Liver in the Dog (1975)

Bile secretion and blood flow in the portal vein and the hepatic artery were determined in cholecystectomized anesthetized dogs before and during continuous infusion of varying doses of secretin. Secretin increases bile volume without alteration of bile acid output. Hepatic arterial flow was not altered by any dose. However, high doses of secretin increased portal venous blood flow significantly. It is concluded that secretin action on liver blood flow mirrors mainly superior mesenteric arterial vasodilation and seems to be a rather pharmacologic than a physiologic response. Bile secretion is not influenced by changes of hepatic blood flow in the physiologic range.
Alternative mortgages: managed risk or gamble? (2006)

Alternative mortgages may increase flexibility for lenders and consumers, but they also add risk. The best advice for all parties is to learn as much as possible about these tools and proceed with caution.
A Model Predictive Control Approach for Low-Complexity Electric Vehicle Charging Scheduling: Optimality and Scalability (2016)

With the increasing adoption of plug-in electric vehicles (PEVs), it is critical to develop efficient charging coordination mechanisms that minimize the cost and impact of PEV integration to the power grid. In this paper, we consider the optimal PEV charging scheduling, where the noncausal information about future PEV arrivals is not known in advance, but its statistical information can be estimated. This leads to an “online” charging scheduling problem that is naturally formulated as a finite-horizon dynamic programming with continuous state space and action space. To avoid the prohibitively high complexity of solving such a dynamic programming problem, we provide a model predictive control (MPC)-based algorithm with computational complexity <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$O(T^3)$</tex-math></inline-formula> , where <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$T$ </tex-math></inline-formula> is the total number of time stages. We rigorously analyze the performance gap between the near-optimal solution of the MPC-based approach and the optimal solution for any distributions of exogenous random variables. Furthermore, our rigorous analysis shows that when the random process describing the arrival of charging demands is first-order periodic, the complexity of the proposed algorithm can be reduced to <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$O(1)$</tex-math></inline-formula> , which is independent of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$T$</tex-math></inline-formula> . Extensive simulations show that the proposed online algorithm performs very closely to the optimal online algorithm. The performance gap is smaller than <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$0.4\%$</tex-math></inline-formula> in most cases.
The ABZzzzs of snoring (1992)

Snorers sleep through their obnoxiously loud breathing, but other members of their household often do not. Their bed partner and family members may grow so tired of the noise that they insist the offender seek medical attention. Physiologic problems such as obesity, narrowing of the airway, or inadequate oropharyngeal muscle tone often can be identified as the cause of snoring. Whenever possible, the underlying disorder should be treated.
SFRIC: A Secure Fast Roaming Scheme in Wireless LAN Using ID-Based Cryptography (2007)

In a wireless network composed of multiple access points, a long delay during roaming from one access point to another may cause a disruption for streaming traffic. Roaming in wireless LAN is generally composed of two parts, 1) searching for a new access point and 2) performing authentication at the new access point. To reduce the second part delay, we propose an innovative lightweight authentication scheme called SFRIC (secure fast /foaming using ID-based cryptography). SFRIC employs ID-based cryptography to simplify the authentication process. It performs mutual authentication for the mobile client and AP with a 3-way handshake, then generates a PTK (pairwise transient key) directly without pre-distributing PMK (pairwise master key). It does not require contacting an authentication server or exchanging certificates. SFRIC is composed of two phases. In the first phase (the preparation phase), each mobile client obtains a temporary private key from the PKG (private key generator). In the second phase (the roaming authentication phase), mutual authentication and key distribution are performed. Our preliminary analysis indicates that SFRIC can complete the roaming authentication within a period much less than the critical 20 ms threshold, required for maintaining streaming traffic, when the cryptographic operations are performed in hardware.
Failure of Ultralightweight Knitted Dacron Grafts in Arterial Reconstruction (1976)

We have observed 11 cases in which the use of the ultralightweight knitted Dacron arterial graft made by the United States Catheter and Instrument Co. (USCI) was complicated by Interstitial hemorrhage dilation, or both. Although the incidence and specific cause of failure of this graft are unknown, we have discontinued its use on the basis of this experience.
Ultraviolet A does not induce melanomas in a <i>Xiphophorus</i> hybrid fish model (2010)

We examined the wavelength dependence of ultraviolet (UV) ra-diation (UVR)-induced melanoma in a Xiphophorus backcross hybrid model previously reported to be susceptible to melanoma induction by ultraviolet A (UVA) and visible light. Whereas ultraviolet B (UVB) irradiation of neonates yielded high frequencies of melanomas in pigmented fish, UVA irradiation resulted in melanoma frequencies that were not significantly different from unirradiated fish. Spontaneous and UV-induced melanoma frequencies correlated with the degree of pigmentation as expected from previous studies, and the histopathology phenotypes of the melanomas were not found in significantly different proportions in UV-treated and -untreated tumor-bearing fish. Our results support the conclusion that a brief early-life exposure to UVB radiation causes melanoma formation in this animal model. These data are consistent with an essential role for direct DNA damage, including cyclobutane dimers and (6-4) photoproducts, in the etiology of melanoma.
Human lives Australia could have saved (2012)

Many of the 100 people who were drowned in the sea near Indonesia last week could have been saved.
Theoretical study of polarization tracking in satellite quantum key distribution (2005)

The BB84 and B92 protocols based on polarization coding are usually used in free-space quantum key distribution. Polarization tracking technique is one of the key techniques in the satellite quantum key distribution. Because the photon polarization state will be changed as a result of the satellite movement, both the transmitter and receiver need to have the ability to track the polarization orientation variation to accomplish the quantum cryptography protocols. In this paper, the polarization tracking principles are analyzed based on Faraday effect and the half-wave plate. The transforms of six photon polarization states in three conjugative bases are given and the quantum key coding principles based on the polarization tracking are analyzed for the BB84 and B92 protocols.
Orientation of aluminum particles in the film formed by aerosol deposition: A mathematical model (2007)

A simple mathematical model predicting the orientation of flat aluminum particles in the operation of painting flat surfaces with metallic paints is developed. The model is additively composed of separate steps accounting for the collision and deformation of a single drop striking against a solid surface, coalescence between the drop and solid surface, relaxation of the drop after the collision and coalescence, and drying by evaporating its volatile components. The calculations made with the developed model for several paint samples showed the agreement between the calculated results and experimental data.
Fusion of panchromatic and multispectral images using multiscale dual bilateral filter (2011)

This paper presents a novel method based on the developed multiscale dual bilateral filter to fuse high spatial resolution panchromatic image and high spectral resolution multispectral image. Compared with traditional multi-resolution based methods, the process of detail extraction considers the characteristics of panchromatic image and multispectral image simultaneously. The low resolution multispectral image is resampled to the same size of the high resolution panchromatic image and sharpened through injecting the extracted details. The proposed fusion method is tested over QuickBird and IKONOS images and compared with three popular methods. The experimental results demonstrate that our method outperforms conventional methods.
AN INTRODUCTION TO GENERALIZED LINEAR MIXED MODELS (1996)

The generalized linear mixed model (GLMM) generalizes the standard linear model in three ways: accommodation of non-normally distributed responses, specification of a possibly non-linear link between the mean of the response and the predictors, and allowance for some forms of correlation in the data. As such, GLMMs have broad utility and are of great practical importance. Two special cases of the GLMM are the linear mixed model (LMM) and the generalized linear model (GLM). Despite the utility of such models, their use has been limited due to the lack of reliable, well-tested estimation and testing methods. I first describe and give examples of GLMMs and then discuss methods of estimation including maximum likelihood, generalized estimating equations, and penalized quasi-likelihood. Finally I briefly survey current research efforts in GLMMs.
Histological and morphometric effects of CdCl2 and ginger on osteoporosis induced by bilateral ovariectomy in adult albino rats (2013)

Cadmium is a widespread environmental pollutant. Low-level environmental cadmium exposure induced osteoporosis especially in postmenopausal women. Ginger is a strong antioxidant that may play an important role in bone formation. The purpose of the present study was to assess the effects of cadmium chloride and ginger on osteoporosis induced by bilateral ovariectomy in adult albino rats. Seventy-two adult albino rat females were used in the present study. They were divided into non-operated groups and operated groups. Cadmium chloride was received at a dose of 3.5 mg/kg daily by subcutaneous injection for 8 weeks, and ginger was fed on a diet containing 5% ginger for 8 weeks. Rats were sacrificed; femurs were dissected out, fixed and decalcified. Serial transverse and longitudinal sections from the diaphysis and metaphysis of femurs were stained by haematoxylin and eosin (H&E) and Masson trichrome stainings and examined using light microscopy. Femurs of Cd-treated, ovariectomized non-treated, and ovariectomized +Cd-treated groups showed histological and morphometric osteoporotic changes that were marked and exaggerated in the ovariectomized +Cd-treated group. Whereas Cd+ginger, ovariectomized +Cd+ginger and ovariectomized+ginger treated groups showed less bone resorption, more bone formation, and improvement in bone structure and morphometric parameters compared to other groups. Cadmium chloride exposure is a risk factor for osteoporosis, especially in postmenopausal women. Ginger effectively ameliorated cadmium and ovariectomy-induced osteoporosis in rats, and is a promising candidate for the prevention and treatment of postmenopausal osteoporosis.
II. Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's‐type dementia (1985)

Neurons identified by their immunoreactivity with antisera against neuropeptide Y (NPY) were studied in three selected areas of the cerebral cortex in brains from controls and in senile dementia of the Alzheimer type (ATD). Changes were more profound in temporal cortex than in parietal cortex, and more severe in parietal cortex than in frontal cortex, paralleling the severity of neuritic plaque formation and incidence of neurofibrillary tangles in these regions. NPY-i neurons became distorted, with enlarged misshapen cell somata and reduced, thickened, and gnarled dendrites. There was a sharp reduction in the extensiveness and delicacy of the axonal plexus; the reorganized axons were haphazard compared to the normal symmetry of these fibers. Besides the alteration in form and sizes, there were also appreciably fewer cells. Nevertheless, the NPY population is not eliminated. Double-label studies of NPY-i and thioflavin indicate that NPY-i fibers can participate in neuritic plaque formation although not all neuritic plaques contained NPY-i axons and not all NPY-i axons were associated with plaques. The surviving NPY cells were evident in all cortices examined, thus giving rise to the speculation that these peptide neurons may have unusual survival and reorganization potential even in terminal neurological disease.
COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps (2020)

Coronavirus disease 2019 (COVID-19) is a virus-induced respiratory disease that may progress to acute respiratory distress syndrome (ARDS) and is triggered by immunopathological mechanisms that cause excessive inflammation and leukocyte dysfunction. Neutrophils play a critical function in the clearance of bacteria with specific mechanisms to combat viruses. The aim of this review is to highlight the current advances in the pathways of neutrophilic inflammation against viral infection over the past ten years, focusing on the production of neutrophil extracellular traps (NETs) and its impact on severe lung diseases, such as COVID-19. We focused on studies regarding hyperinflammation, cytokine storms, neutrophil function, and viral infections. We discuss how the neutrophil's role could influence COVID-19 symptoms in the interaction between hyperinflammation (overproduction of NETs and cytokines) and the clearance function of neutrophils to eliminate the viral infection. We also propose a more in-depth investigation into the neutrophil response mechanism targeting NETosis in the different phases of COVID-19.
RIPng Protocol Applicability Statement (1997)

As required by Routing Protocol Criteria (RFC 1264), this report defines the applicability of the RIPng protocol within the Internet.This report is a prerequisite to advancing RIPng on the standards track. Protocol
Comparative Study of Bezafibrate and Probucol in Hyperlipidaemia (1989)

Sixty out-patients diagnosed as having hyperlipidaemia, with a cholesterol level of greater than 200 mg/dl and/or a triglycerides level of greater than 200 mg/dl, took part in the trial. Patients were divided at random into two groups to receive pharmacological treatment plus diet; one group was given 500 mg probucol twice a day and the other group 200 mg bezafibrate twice or 3-times a day for an average treatment period of 60 days. The percentage changes in serum lipids, i.e. total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol, were evaluated by comparing the values before and at the end of treatment, and tolerability of the drug in use was evaluated from the appearance of adverse reactions and the ECG and blood pressure parameters. Whereas total cholesterol and LDL-cholesterol levels were reduced to a similar extent in both groups (cholesterol - 42% bezafibrate, 38.3% probucol; LDL-cholesterol - 30.8% bezafibrate, 26.5% probucol), triglycerides were reduced to a significantly greater extent (p less than 0.05) in the benzafibrate group (55.5%) than in the probucol group (24.0%). The most significant percentage change (p less than 0.005) was found with HDL-cholesterol; in the bezafibrate group, levels increased by 19.0% compared with a 11.8% reduction in the probucol group. Four (13.3%) patients on bezafibrate and 5 (16.7%) on probucol reported mild to moderately severe side-effects, mainly gastro-intestinal, but in no case was treatment interrupted, although benzafibrate dosage was temporarily reduced. ECG changes (prolongation of QTc) were recorded in 3 patients on probucol and these reverted to normal after the end of the trial.