gebhart/patrepeval huggingface dataset:
H. M.’s Medial Temporal Lobe Lesion: Findings from Magnetic Resonance Imaging (1997)

Although neuropsychological studies of the amnesic patient H. M. provide compelling evidence that normal memory function depends on the medial temporal lobe, the full extent of his surgical resection has not been elucidated. We conducted magnetic resonance imaging studies to specify precisely the extent of his bilateral resection and to document any other brain abnormalities. The MRI studies indicated that the lesion was bilaterally symmetrical and included the medial temporal polar cortex, most of the amygdaloid complex, most or all of the entorhinal cortex, and approximately half of the rostrocaudal extent of the intraventricular portion of the hippocampal formation (dentate gyrus, hippocampus, and subicular complex). The collateral sulcus was visible throughout much of the temporal lobe, indicating that portions of the ventral perirhinal cortex, located on the banks of the sulcus, were spared; the parahippocampal cortex (areas TF and TH) was largely intact. The rostrocaudal extent of the ablation was approximately 5.4 cm (left) and 5.1 cm (right). The caudal 2 cm, approximately, of the hippocampus body (normal length, approximately 4 cm) was intact, although atrophic. The temporal stem was intact. Outside the temporal lobes, the cerebellum demonstrated marked atrophy, and the mammillary nuclei were shrunken. The lateral temporal, frontal, parietal, and occipital lobe cortices appeared normal for age 66 years. The mediodorsal thalamic nuclei showed no obvious radiological changes. These findings reinforce the view that lesions of the hippocampal formation and adjacent cortical structures can produce global and enduring amnesia and can exacerbate amnesia beyond that seen after more selective hippocampal lesions.
A Mixture Model for Distributions of Correlation Coefficients (1989)

An old problem in personnel psychology is to characterize distributions of test validity correlation coefficients. The proposed model views histograms of correlation coefficients as observations from a mixture distribution which, for a fixed sample size n , is a conditional mixture distribution h ( r|n ) = Σ j λ j h ( r ; ρ j , n ), where R is the correlation coefficient, ρ j are population correlation coefficients and λ j are the mixing weights. The associated marginal distribution of R is regarded as the parent distribution underlying histograms of empirical correlation coefficients. Maximum likelihood estimates of the parameters ρ j and λ j can be obtained with an EM algorithm solution and tests for the number of components t are achieved after the (one-component) density of R is replaced with a tractable modeling density h ( r ; ρ j , n ). Two illustrative examples are provided.
Increased body fat in mice with a targeted mutation of the paternally expressed imprinted gene <i>Peg3</i> (2005)

Peg3 encodes a C2H2 type zinc finger protein that is implicated in a novel physiological pathway regulating core body temperature, feeding behavior, and obesity in mice. Peg3+/- mutant mice develop an excess of abdominal, subcutaneous, and intra-scapular fat, despite a lifetime of lower food intake than wild-type animals. However, they start life with reduced fat reserves and are slower to enter puberty. These mice maintain a lower core body temperature, fail to respond to a cold challenge, and have lower metabolic activity as measured by oxygen consumption. Plasma leptin levels are significantly higher than in wild types, and Peg3+/- mice appear to have developed leptin resistance. Administration of exogenous leptin resulted in a significant reduction in food intake in wild-type mice that was not observed in Peg3+/- mutants. This mutation, which is strongly expressed in hypothalamic tissue during development, has the capacity to regulate multiple events relating to energy homeostasis.
Combined Genetic and Metabolic Manipulation of Lipids in <i>Rhodobacter sphaeroides</i> Reveals Non-Phospholipid Substitutions in Fully Active Cytochrome <i>c</i> Oxidase (2011)

A specific requirement for lipids, particularly cardiolipin (CL), in cytochrome c oxidase (CcO) has been reported in many previous studies using mainly in vitro lipid removal approaches in mammalian systems. Our accompanying paper shows that CcO produced in markedly CL-depleted Rhodobacter sphaeroides displays wild-type properties in all respects, likely allowed by quantitative substitution with other negatively charged lipids. To further examine the structural basis for the lipid requirements of R. sphaeroides CcO and the extent of interchangeability between lipids, we employed a metabolic approach to enhance the alteration of the lipid profiles of the CcO-expressing strains of R. sphaeroides in vivo using a phosphate-limiting growth medium in addition to the CL-deficient mutation. Strikingly, the purified CcO produced under these conditions still maintained wild-type function and characteristics, in spite of even greater depletion of cardiolipin compared to that of the CL-deficient mutant alone (undetectable by MS) and drastically altered profiles of all the phospholipids and non-phospholipids. The lipids in the membrane and in the purified CcO were identified and quantified by ESI and MALDI mass spectrometry and tandem mass spectrometry. Comparison between the molecular structures of those lipids that showed major changes provides new insight into the structural rationale for the flexible lipid requirements of CcO from R. sphaeroides and reveals a more comprehensive interchangeability network between different phospholipids and non-phospholipids.
Tunable compensation of the dispersion slope mismatch in dispersion-managed systems using a sampled nonlinearly-chirped FBG (2002)

We demonstrate tunable dispersion slope compensation for three 10 Gbit/s WDM channels using a sampled nonlinearly-chirped FBG. The replicated sampled-FBG wavelength bands have a different separation than the WDM channels, causing each channel to experience a different dispersion compensation that can be tuned upon stretching of the FBG. We achieve significant power penalty reduction using our tunable dispersion-slope-compensation method over 900 and 1200 km fiber links.
Monodisperse, Molecularly Imprinted Polymer Microspheres Prepared by Precipitation Polymerization for Affinity Separation Applications (2003)

Theophillin-geprägte Polymermikrokügelchen mit Durchmessern von etwa 5 μm (siehe Bild) wurden in einem einzigen Syntheseschritt durch Fällungspolymerisation erhalten. Das stabile monodisperse Material konnte in der HPLC eingesetzt werden und dürfte sich im Prinzip für jede Anwendung eignen, die auf einer molekularen Erkennung beruht.
Prenatal diagnosis and carrier detection for molybdenum cofactor deficiency type A in Northern Israel using polymorphic DNA markers (2000)

Molybdenum cofactor deficiency (MoCoD) is an autosomal recessive, fatal neurological disorder, characterized by the combined deficiency of sulphite oxidase, xanthine dehydrogenase and aldehyde oxidase. We have recently reported an excessive occurrence of this fatal disorder among segments of the Arab population in Northern Israel suggesting that the true incidence of MoCoD is probably underestimated in this highly inbred population. This lethal disease can be diagnosed prenatally by assay of sulphite oxidase activity in chorionic villus samples in pregnancies of couples who have had previously affected children (obligatory carriers). However, to date, there is no biochemical assay for carrier detection among the population at risk. Recently we demonstrated the linkage of a MoCoD gene to an 8-cM region on chromosome 6p21.3 in two consanguineous Israeli–Arab unrelated kindreds. The description of the MOCS1 gene that maps to the same region and which carries multiple mutations in MoCoD type A followed this finding. We describe here one additional kindred of Arab–Israeli origin, which is also linked to the MOCS1 locus, and demonstrate the feasibility of prenatal diagnosis and carrier detection using microsatellite markers in selected families when mutations are unknown. A complete correlation between the biochemical and DNA assays was found in a total of six samples (five chorionic villus and one amniocyte culture sample) obtained from the three MoCoD families. Copyright © 2000 John Wiley & Sons, Ltd.
Identifying the superior measure of rapid fibrosis for predicting premature cirrhosis after liver transplantation for hepatitis C (2013)

Different measures of RF progression identify different risks for RF and are not directly comparable. Fibrosis rate was the most accurate predictor of rapid graft cirrhosis.
Pure vibrational spectroscopy of <i>S</i>0 formaldehyde by dispersed fluorescence (1996)

Dispersed fluorescence spectra from the 000 rotational level of 40, 41, 51, and 3141 S1 formaldehyde (H2CO) have been recorded. From these spectra, 198 new vibrational states have been assigned with energies up to 12 500 cm−1, and their positions have been determined to within an uncertainty of 1 cm−1. The assignment of vibrational lines to specific vibrational states becomes increasingly difficult at the higher energy regions of the spectra (≳9000 cm−1) due to extensive state mixing. Harmonic and first-order anharmonic vibrational constants were extracted from fits to these vibrational states. For states with highest zero-order coefficient squared greater than 35%, the standard deviation of the spectroscopic fit is 6.9 cm−1. For states which are lower energy (&lt;9500 cm−1) and relatively pure (zero-order coefficient squared greater than 0.75 or largest in a given normal mode combination), the standard deviation is 1.7 cm−1. Good agreement with ab initio vibrational constants calculated by Martin et al. [J. Mol. Spectrosc. 160, 105 (1993)] is achieved, except in cases where all observed states contributing to the determination of a particular constant are significantly mixed. These deviations are readily explained by a consideration of anharmonic vibrational interactions that occur among specific combinations of normal modes. The average mean deviation between all experimentally determined energies and a recent theoretical calculation by Burleigh et al. [J. Chem. Phys. 104, 480 (1996)] is 2.6 cm−1.
Presentation And Validation Of Erythrocyte Aggregation By Light Scattering Analysis (2005)

The erythroaggregometer* Sefam (NancyFrance) allows an approach of erythrocyte aggregation by the analysis of backscattered light intensity. The apparatus is described and the principle of measurements is given. The apparatus gives kinetic parameters (aggregation time), structural index and desaggregation shear rate threshold. Reproducibility is satisfactory. The measurement is dependant of experimental conditions which has to be described. The apparatus is sensible to fibrinogen variations and damaged red cells. Normal values are defined and interpreted from a reference population.
Isolation, Purification, and Cultivation of Murine and Human Keratinocytes (2004)

The architecture of mammalian skin incorporates an outer layer of stratified epithelium. This enables the organism to conserve internal homeostasis and maintain protection from adverse environmental exposure. The keratinocyte is the cell primarily responsible for this structure. Isolation and in vitro cultivation of this cell type is widely used in dermatological and other investigations as opposed to using whole animals. However, this cell is very fastidious as compared to other skin cells (fibroblasts, etc.) and thus requires special procedures to obtain successful in vitro cultivation. This chapter describes the methodology required to isolate, purify, and cultivate keratinocytes to produce both monolayer and stratified cultures. The methodologies for producing cultures of keratinocytes obtained from rat skin and from human skin are described.
Lethality and Cost of Medication-Related Complications in Elderly Surgical Patients: Lessons Learned from a Harm Reduction Campaign (2014)

Adams, Peter D. MD; Kather, Ryan; Chamberlain, Justin L. MD; Rubinfeld, Ilan S. MD, FACS Author Information
Profiles of ILY, VLY and Sm-hPAF interaction with human CD59. (2013)

A hydrogen bond (ILY Arg432-hCD59 Glu76) was observed between ILY and hCD59, and a stronger interaction was formed by flexible adjustment between them.
Separation of a Set of Peptide Sequence Isomers Using Differential Ion Mobility Spectrometry (2011)

Protein identification in bottom-up proteomics requires disentangling isomers of proteolytic peptides, a major class of which are sequence inversions. Their separation using ion mobility spectrometry (IMS) has been limited to isomeric pairs. Here we demonstrate baseline separation of all seven 8-mer tryptic peptide isomers using differential IMS. Evaluation of peak capacity implies that even larger libraries should be resolved for heavier peptides with higher charge states.
Controlled and selective introduction of a Cp*Ru+ (Cp* = C5Me5) fragment to the 17.alpha.-substituent of 17.alpha.-phenylestradiol (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleControlled and selective introduction of a Cp*Ru+ (Cp* = C5Me5) fragment to the 17.alpha.-substituent of 17.alpha.-phenylestradiolDominique Vichard, Michel Gruselle, Hani El Amouri, Gerard Jaouen, and Jacqueline VaissermannCite this: Organometallics 1992, 11, 8, 2952–2956Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/om00044a045https://doi.org/10.1021/om00044a045research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automated reconstruction of building facades for virtual walk-thrus (2003)

In this paper, we present a fast, automated approach to generating a highly detailed, textured 3D building facade model. This model is acquired at the ground level by driving a vehicle equipped with laser scanners and a digital camera under normal traffic conditions on public roads, and then processed offline. We evaluate our approach on a large data set acquired in downtown Berkeley.
GENE-17. ATRX LOSS IN GLIOMA RESULTS IN EPIGENETIC DYSREGULATION OF THE G2/M CHECKPOINT AND SENSITIVITY TO ATM INHIBITION (2019)

Abstract Gliomas are a leading cause of cancer mortality in children and adults and new targeted therapies are desperately needed. ATRX is a chromatin remodeling protein that is recurrently mutated in H3F3A-mutant pediatric GBM and IDH-mutant grade 2/3 adult glioma. We previously showed that loss of ATRX in glioma results in tumor growth and additional tumor mutations. However, the mechanism driving these phenotypes has not been fully established. We found that in ChIP-Seq datasets of mouse neuronal precursor cells (NPCs) and experimental models of human glioma cells, ATRX binds and regulates the chromatin state of promoters and enhancers for gene sets associated with regulation of the cell cycle G2/M checkpoint. In line with this, analysis of single-cell seq (sc-seq) data from IDH-mutant gliomas (n=16) shows that ATRX-mutant tumors (IDH-A) demonstrate a population of cycling cells with dysregulated cell cycle phase gene set expression when compared to ATRX-wildtype tumors (IDH-O). In glioma models, ATRX-deficient cells exhibit a seven-fold increase in mitotic index at 16 hours after sub-lethal radiation and enhanced activation of the master cell cycle regulator ATM with radiation. Treatment of ATRX-deficient gliomas with ATM inhibitors results in a selective increase in dysfunctional cell cycling and increased radio-sensitization in ATRX-deficient glioma cells. Using an ATM-luciferase reporter in orthotopically-implanted human GBM cells, both AZD0156 and AZD1390 demonstrate in vivo pathway inhibition. Mice intra-cranially implanted with ATRX-deficient GBM cells demonstrate a doubling of median survival compared to radiated controls (p=0.0018) when treated with AZD0156 combined with radiation. This study demonstrates that ATRX-deficient glioma display epigenetic dysregulation of the G2/M checkpoint, which opens a new window for therapies targeting this unique phenotype.
Interactions Between Antipsychotic and Antihypertensive Drugs (1995)

No antipsychotic-antihypertensive combination is absolutely contraindicated, but no combination should be considered to be completely without risk. Antihypertensives with no centrally acting activity, such as diuretics, may be the least likely to result in adverse reactions. The combination of the beta-antagonists propranolol or pindolol with thioridazine or chlorpromazine should be avoided if possible. Scrupulous patient monitoring for attenuated or enhanced activity of either agent is essential whenever antipsychotics and antihypertensives are given concurrently.
ChemInform Abstract: cis‐5‐Alkyl(or Alkenyl)‐3‐phenyl‐3(1H‐imidazol‐1‐ylmethyl)‐2‐methylisoxazolidine Derivatives: In vitro Antifungal Activity and Structure‐Activity Relationships. (1989)

ChemInformVolume 20, Issue 26 Other Subjects ChemInform Abstract: cis-5-Alkyl(or Alkenyl)-3-phenyl-3(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine Derivatives: In vitro Antifungal Activity and Structure-Activity Relationships. P. A. SWIFT, P. A. SWIFT Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorG. A. BENNETT, G. A. BENNETT Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorG. B. MULLEN, G. B. MULLEN Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorJ. T. MITCHELL, J. T. MITCHELL Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorS. D. ALLEN, S. D. ALLEN Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorC. R. KINSOLVING, C. R. KINSOLVING Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorV. S. GEORGIEV, V. S. GEORGIEV Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this author P. A. SWIFT, P. A. SWIFT Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorG. A. BENNETT, G. A. BENNETT Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorG. B. MULLEN, G. B. MULLEN Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorJ. T. MITCHELL, J. T. MITCHELL Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorS. D. ALLEN, S. D. ALLEN Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorC. R. KINSOLVING, C. R. KINSOLVING Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this authorV. S. GEORGIEV, V. S. GEORGIEV Dep. Org. Chem., Pharm. Div., Pennwalt Corp., Rochester, NY 14623, USASearch for more papers by this author First published: June 27, 1989 https://doi.org/10.1002/chin.198926338AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume20, Issue26June 27, 1989 RelatedInformation
SIMULTANEOUS PROBING OF SINGLE ERYTHROCYTE BIOCHEMCAL AND MECHANICAL PROPERTIES FOR EFFICIENT BLOOD TRANSFUSION (2013)

The age of stored blood plays a critical risk factor in blood transfusion [1, 2]. The strong connection between RBC clearance and the age of stored blood leads us to believe that age-dependent biochemical and mechanical changes play a key role in RBC clearance after transfusion. In this project, we are interested in finding out if these changes are more specific to a subpopulation of stored blood. Furthermore, a label-free RBC deformability based sorting [3] is performed to pre-filter less deformable RBCs. It is hoped that this pre-filtration prior to blood transfusion can potentially reduce in vivo RBC clearance of transfused blood, and other side effects of blood transfusion.
Mice deficient in invariant‐chain and MHC class II exhibit a normal mature B2 cell compartment (2004)

The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed that this fragment is required for activation of the NF-kappaB pathway as a means of controlling B cell maturation. The opposing view holds that defects in the assembly of MHC class II molecules result in impaired B cell development. Here we demonstrate that a lack of Ii indeed causes defects in B cell development, with fewer mature B cells in the periphery as previously reported, but that in a compound-mutant from which both Ii and all MHC class II subunits are absent, B cell development is normal. We suggest that neither Ii itself, nor the MHC class II products are required for normal B cell development.
Re: Robot-Assisted AMS-800 Artificial Urinary Sphincter Bladder Neck Implantation in Female Patients with Stress Urinary Incontinence (2019)

No AccessJournal of UrologyUrological Survey1 Sep 2019Re: Robot-Assisted AMS-800 Artificial Urinary Sphincter Bladder Neck Implantation in Female Patients with Stress Urinary Incontinence Jeffrey A. CadedduMD Jeffrey A. CadedduJeffrey A. Cadeddu More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000367AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Robot-Assisted AMS-800 Artificial Urinary Sphincter Bladder Neck Implantation in Female Patients with Stress Urinary Incontinence." The Journal of Urology, 202(3), pp. 441–442 Suggested Reading : Surgical treatment of female stress urinary incontinence: AUA/SUFU guideline. J Urol 2017; 198: 875. Link, Google Scholar © 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 202Issue 3September 2019Page: 441-442 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jeffrey A. Cadeddu More articles by this author Expand All Advertisement PDF downloadLoading ...