gebhart/patrepeval huggingface dataset:
Genetic Effects on Postprandial Variations of Inflammatory Markers in Healthy Individuals (2009)

Circulating levels of inflammatory markers predict the risk of cardiovascular disease (CVD), mediated perhaps in part by dietary fat intake, through mechanisms only partially understood. To evaluate post-fat load changes in inflammatory markers and genetic influences on these changes, we administered a standardized high-fat meal to 838 related Amish subjects as part of the Heredity and Phenotype Intervention (HAPI) Heart Study and measured a panel of inflammatory markers, including C-reactive protein (CRP), interleukin-1beta (IL-1beta), matrix metalloproteinase-1 and -9 (MMP-1 and MMP-9), and white blood cell (WBC) count, before and 4 h after fat challenge (CRP prechallenge only). Heritabilities (h(2) +/- s.d.) of basal inflammatory levels ranged from 16 +/- 8% for MMP-9 (P = 0.02) to 90 +/- 7% for MMP-1 (P < 0.0001). Post-fat load, circulating levels of WBC, MMP-1, and MMP-9 increased by 16, 32, and 43% (all P < 0.0001), with no significant changes in IL-1beta. Postprandial changes over the 4-h period were modestly heritable for WBC (age- and sex-adjusted h(2) = 14 +/- 9%, P = 0.04), but the larger MMP-1 and MMP-9 changes appeared to be independent of additive genetic effects. These results reveal that a high-fat meal induces a considerable inflammatory response. Genetic factors appear to play a significant role influencing basal inflammatory levels but to have minimal influence on post-fat intake inflammatory changes.
Discovery of 1-[4-(3-Chlorophenylamino)-1-methyl-1<i>H</i>-pyrrolo[3,2-<i>c</i>]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a Brain Penetrant 5-Azaindole CB<sub>2</sub>Agonist for the Treatment of Chronic Pain (2009)

We report the synthesis and SAR of a series of novel azaindole CB(2) agonists. 6-Azaindole 18 showed activity in an acute pain model but was inactive in a chronic model. 18 is a Pgp substrate with low brain penetration. The template was redesigned, and the resulting 5-azaindole 36 was a potent CB(2) agonist with high CNS penetration. This compound was efficacious in the acute model and the chronic joint pain model.
Frequency Domain Fluorometry: Theory and Application (2013)

Frequency domain fluorometry is a widely utilized tool in the physical, chemical, and biological sciences. This chapter focuses on the theory of the method and the practical aspects required to carry out intensity decay, i.e., lifetime measurements on a modern frequency domain fluorometer. Several chemical/biological systems are utilized to illustrate data acquisition protocols. Data analysis procedures and methodologies are also discussed.
Flow of a concentrated suspension through an abrupt axisymmetric expansion measured by nuclear magnetic resonance imaging (2005)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Tracey Moraczewski, Haiying Tang, Nina C. Shapley; Flow of a concentrated suspension through an abrupt axisymmetric expansion measured by nuclear magnetic resonance imaging. J. Rheol. 1 November 2005; 49 (6): 1409–1428. https://doi.org/10.1122/1.2079227 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
Loss of circadian rhythmicity in aging<i>mPer1</i><sup>-/-</sup><i>mCry2</i><sup>-/-</sup>mutant mice (2003)

The mPer1, mPer2, mCry1, and mCry2 genes play a central role in the molecular mechanism driving the central pacemaker of the mammalian circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus. In vitro studies suggest a close interaction of all mPER and mCRY proteins. We investigated mPER and mCRY interactions in vivo by generating different combinations of mPer/mCry double-mutant mice. We previously showed that mCry2 acts as a nonallelic suppressor of mPer2 in the core clock mechanism. Here, we focus on the circadian phenotypes of mPer1/mCry double-mutant animals and find a decay of the clock with age in mPer1-/- mCry2-/- mice at the behavioral and the molecular levels. Our findings indicate that complexes consisting of different combinations of mPER and mCRY proteins are not redundant in vivo and have different potentials in transcriptional regulation in the system of autoregulatory feedback loops driving the circadian clock.
Optical windows for a flow cell to contain aqueous solutions at high pressure and temperature (1995)

A flow cell to contain aqueous solutions at pressures up to 40 MPa and temperatures up to 600 °C that is equipped with sapphire windows for the transmission of visible light is described. There are four windows, two for the entrance and exit of a laser beam, and two located at 90° that feature f/1 (53° included angle) collection apertures with a 9 mm diameter unobstructed view for Raman spectroscopy, absorption measurements, or studies using full-field back illumination. The window-to-metal seals are gold o-rings; the metal-to-metal seals are gaskets prepared by pressing a gold o-ring onto a gold foil washer. This cell has been used for two years for Raman studies of aqueous solutions at high pressures and temperatures both below and above the supercritical point of water.
Collective collapse of a Bose-Einstein condensate with attractive interactions (1999)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation C. A. Sackett, J. M. Gerton, M. Welling, R. G. Hulet; Collective collapse of a Bose-Einstein condensate with attractive interactions. AIP Conf. Proc. 11 June 1999; 477 (1): 58–73. https://doi.org/10.1063/1.59369 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Cosmogenic 3He and 21Ne age of the Big Lost River flood, Snake River Plain, Idaho (1994)

Research Article| March 01, 1994 Cosmogenic 3He and 21Ne age of the Big Lost River flood, Snake River Plain, Idaho Thure E. Cerling; Thure E. Cerling 1Department of Geology and Geophysics, University of Utah, Salt Lake City, Utah 84112 Search for other works by this author on: GSW Google Scholar Robert J. Poreda; Robert J. Poreda 2Department of Geological Sciences, University of Rochester, Rochester, New York 14627 Search for other works by this author on: GSW Google Scholar Sara L. Rathburn Sara L. Rathburn 3Department of Geology, Miami University, Oxford, Ohio 45056 Search for other works by this author on: GSW Google Scholar Author and Article Information Thure E. Cerling 1Department of Geology and Geophysics, University of Utah, Salt Lake City, Utah 84112 Robert J. Poreda 2Department of Geological Sciences, University of Rochester, Rochester, New York 14627 Sara L. Rathburn 3Department of Geology, Miami University, Oxford, Ohio 45056 Publisher: Geological Society of America First Online: 02 Jun 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (1994) 22 (3): 227–230. https://doi.org/10.1130/0091-7613(1994)022<0227:CHANAO>2.3.CO;2 Article history First Online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation Thure E. Cerling, Robert J. Poreda, Sara L. Rathburn; Cosmogenic 3He and 21Ne age of the Big Lost River flood, Snake River Plain, Idaho. Geology 1994;; 22 (3): 227–230. doi: https://doi.org/10.1130/0091-7613(1994)022<0227:CHANAO>2.3.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract The Big Lost River flood in southeastern Idaho occurred 20,500 calibrated yr B.P., on the basis of dates derived from cosmogenic 3He and 21Ne measurements of samples from flood-deposited boulders and from scour features. This date corresponds to a date of 16,90014C yr B.P. and is close in age to several other cataclysmic flood events in western North America; it may mark evidence for widespread warming at the end of the Pleistocene in western North America. The Big Lost River flood was smaller than some other late Pleistocene floods, such as the Bonnevi1le flood and the Missoula floods; thus, some samples exposed after the flood had significant amounts of cosmogenic 3He and 21Ne that was acquired before the flood occurred. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Lung Thermal Transfer System Identification With Fractional Models (2018)

System identification through fractional models is proposed for modeling thermal transfers in the lungs. In general, during open-heart surgery, an extracorporeal circulation is carried out on the patient. First, the lungs are disconnected from the circulatory system so that an artificial heart/lung machine can be plugged on the bloodstream. Pulmonary cells die when they are no more supplied with fresh blood, which may result in postoperative respiratory complications for the patient. Also, bronchial hypothermia is carried out to protect the lungs. Indeed, cooling the lung organ helps slowing down its deterioration. Unfortunately, the lung thermal properties are not well known yet; therefore, mathematical models are useful and needed in order to improve the knowledge of these organs. As proved by several previous works, fractional models are well suited to model the dynamics of fractal systems and to model thermal systems, thanks to its model parameter compactness but also thanks to the solving of the heat equation whose analytical result reveals a fractional differentiation operator of order 0.5. System identification results are provided on real data measured on sheep lungs. Thus, this paper studies the comparison between a rational model and two kinds of fractional models, a classic one and another one using the Havriliak-Negami function. Time-domain and frequency-domain analysis are provided, showing the efficiency of fractional models, but more precisely of Havriliak-Negami transfer functions.
Spin-Lattice Relaxation of Protons in Uranium Hydride (1973)

$\ensuremath{\beta}\ensuremath{-}\mathrm{U}{\mathrm{H}}_{3}$ is known to be ferromagnetic below 180 \ifmmode^\circ\else\textdegree\fi{}K. The spin-lattice relaxation time ${T}_{1}$ of the protons in the paramagnetic state has been measured in the temperature range 189-700 \ifmmode^\circ\else\textdegree\fi{}K. At low temperatures close to the ferromagnetic transition, there is a steep rise in ${T}_{1}$ with temperature. At high temperatures, around 613 \ifmmode^\circ\else\textdegree\fi{}K, there is a local minimum in ${T}_{1}$. It is shown that there are three mechanisms contributing to the relaxation rate: (a) time-dependent nuclear dipole-dipole interaction caused by hydrogen diffusion; (b) contact interaction between the conduction electrons and the protons, causing Korringa relaxation; and (c) Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction between the protons and the localized $f$ electrons via the conduction electrons; the relaxation caused by this interaction was found to fit Fradin's model. Separation of the three contributions from each other is achieved using their different temperature dependence. Measurement of the spin echo ${T}_{2}$ yields the value ${E}_{a}=19.25$ kcal/mole for the activation energy of hydrogen diffusion. The Korringa contribution is $\frac{1}{{T}_{1K}T}=0.135\ifmmode\pm\else\textpm\fi{}0.021$ sec $^{\ensuremath{-}1}\mathrm{\ifmmode^\circ\else\textdegree\fi{}}\mathrm{K}^{\ensuremath{-}1}$. The paramagnetic part is $\frac{1}{{T}_{1f}T}=\frac{(101\ifmmode\pm\else\textpm\fi{}3)}{(T\ensuremath{-}\ensuremath{\Theta})}$ ${\mathrm{sec}}^{\ensuremath{-}1}$ \ifmmode^\circ\else\textdegree\fi{}${\mathrm{K}}^{\ensuremath{-}}$. Using Fradin's model we get for the density of states of the $s$-type conduction electrons at the Fermi level, $N({E}_{F})=1.65$ states/eV. The coupling constant for the contact interaction is $\ensuremath{\Delta}=5.6\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}7}$ eV. The exchange constant between the localized $5f$ electrons and the $s$-type conduction electrons is $\ensuremath{\Gamma}=0.18$ eV. The Knight factor is $\ensuremath{\xi}=0.12$. If one assumes a spherical Fermi surface and a free-electron behavior in the RKKY interaction, then the degree of ionicity of the uranium ion is shown to be ${\mathrm{U}}^{+3}$.
Übergangsmetall-Carben-Komplexe, CVIII<sup>1</sup> µ-Methyliden-Komplexe des Rheniums / Transition Metal Carbene Complexes, CVIII<sup>1</sup> µ-Methylidene Complexes of Rhenium (1977)

The reaction of Re 2 (CO) 10 and Re 2 (CO) 9 C(OCH 3 )R [R = C 6 H 5 ; C 6 H 4 CH 3-p ] with lithium aryls and subsequent alkylation with trimethyloxonium tetrafluoroborate exceeds the stage of the carbene compound to form new μ-methylidene complexes.
High resolution radar imaging systems with robust image restoration (2002)

The paper presents a robust approach to image restoration that combines the properties of classical regularized iterative algorithms and robust features based on the concept of M-estimators. The approach takes into consideration the peculiarities of radar image formation to provide optimal noise removal and image restoration including suppression of ringing, and preservation of edges and fine details.
Orthanilic acid-promoted reverse turn formation in peptides (2013)

Orthanilic acid (2-aminobenzenesulfonic acid, (S)Ant), an aromatic β-amino acid, has been shown to be highly useful in inducing a folded conformation in peptides. When incorporated into peptide sequences (Xaa-(S)Ant-Yaa), this rigid aromatic β-amino acid strongly imparts a reverse-turn conformation to the peptide backbone, featuring robust 11-membered-ring hydrogen-bonding.
DELAYED IMPLOSION OF THE <i>Z</i>-PINCH IN NITROGEN (1963)

The paper presents the first photographic evidence of the delayed implosion of the Z-pinch in nitrogen at pressures in excess of 375 μ Hg. Two implosions are observed before the discharge column is compressed to its minimum diameter. The time interval between the two implosions is found to increase linearly with pressure.The radius of the discharge column as a function of time is measured with a framing camera and is also calculated from the electrical characteristics of the discharge. By comparing the computed and measured values of the radius of the discharge column at given pressures, it has been shown that the second implosion does not arise from a transfer of the discharge current into material near the walls of the discharge vessel, in contrast to results commonly observed in very energetic discharges.
Analysis of the test data volume reduction benefit of modular SOC testing (2008)

Modular SOC testing offers numerous benefits that include test power reduction, ease of timing closure, and test re-use among many others. While all these benefits have been emphasized by researchers, the test time and data volume comparisons has been mostly constrained within the context of modular SOC testing only, by comparing the impact of various different modular SOC testing techniques to each other. In this paper, we provide a theoretical test data volume analysis that compares the monolithic test of a flattened design with the same design tested in a modular manner; we present numerous experiments that gauge the magnitude of this benefit. We show that the test data volume reduction delivered by modular SOC testing directly hinges on the test pattern count variation across different modules, and that this reduction can exceed 99% in the SOC benchmarks that we have experimented with.
Turbulence thermal blooming interactions: static (1990)

In view of the possibility that turbulence-thermal blooming interactions (TTBI) in laser beam atmospheric propagation may yield rapidly growing small scintillations, and ultimately lead to severe beam degradation, attention is presently given to a Born approximation/perturbation transmitter system in a turbulent atmosphere without net wind or beam slew, but with the important effect of 'smearing' in high spatial frequency wavefront distortion due to a random (zero mean) atmospheric wind velocity. The perturbed high energy beam, as well as the perturbed probe beam sensed by the adaptive optics system, are shown to satisfy a system of first-order linear ordinary differential equations. It is found that the presence of the small random wind plays a major role in limiting the growth of TTBI effects.
ChemInform Abstract: Stereocontrolled Synthesis of 4‐Substituted (.+‐.)‐Kainic Acids. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Additional file 1 of RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells (2017)

Supplementary Material. Detailed description of the modeling and data analysis procedures. (PDF 1106 kb)
Theoretical and Practical Boundaries of Binary Secure Sketches (2008)

Fuzzy commitment schemes, introduced as a link between biometrics and cryptography, are a way to handle biometric data matching as an error-correction issue. We focus here on finding the best error-correcting code with respect to a given database of biometric data. We propose a method that models discrepancies between biometric measurements as an erasure and error channel, and we estimate its capacity. We then show that two-dimensional iterative min-sum decoding of properly chosen product codes almost reaches the capacity of this channel. This leads to practical fuzzy commitment schemes that are close to theoretical limits. We test our techniques on public iris and fingerprint databases and validate our findings.
Comparison of the Susceptibility to Soft Errors of SRAM-Based FPGA Error Correction Codes Implementations (2012)

Nowadays the reliability issues of SRAM-based Field Programmable Gate Arrays (FPGAs) operating in harsh environments are well understood. One major effect is Single Event Upsets (SEUs), which are able to invert the stored logical value in flip-flops and memory cells. This issue is more serious when the affected memory cells are part of the configuration memory used for programming the circuit functionality. The consequences may be alterations of the circuit functionality causing errors which may only be corrected by reprogramming the device. For a better understanding of the robustness of programmed circuits, this paper compares two decoders for Error Correction Codes (ECCs). A Hamming Decoder and a One-Step Majority Logic Decoder (OS-MLD) for the Difference-Set Cyclic Codes (DSCC) are analyzed yielding surprisingly unexpected results for their SEU susceptibility, which are interesting for application designers.
Osaka developing story (2010)

In this paper, we put forward a novel idea to create virtual alter egos by using video images of real-world humans; these alter egos can act autonomously and interactively in a virtual world. The design inspiration of this virtual world is City in the Meiji era, with many motive and fantasy factors. The application that is used to establish such alter egos in the virtual world is based on Video Agents; a system that can establish interactive autonomous characters by using video images of real-world creatures. If you will, you can create your own alter ego, which will enter the virtual world and behave autonomously; just like another you living in another world. The created Osaka Developing Story was demonstrated at a special event in Osaka, and a lot of participants enjoyed their own incredible experiences. This paper describes its implementation details and results.
Overexpression of <i>AtMYB44</i> Enhances Stomatal Closure to Confer Abiotic Stress Tolerance in Transgenic Arabidopsis (2007)

AtMYB44 belongs to the R2R3 MYB subgroup 22 transcription factor family in Arabidopsis (Arabidopsis thaliana). Treatment with abscisic acid (ABA) induced AtMYB44 transcript accumulation within 30 min. The gene was also activated under various abiotic stresses, such as dehydration, low temperature, and salinity. In transgenic Arabidopsis carrying an AtMYB44 promoter-driven beta-glucuronidase (GUS) construct, strong GUS activity was observed in the vasculature and leaf epidermal guard cells. Transgenic Arabidopsis overexpressing AtMYB44 is more sensitive to ABA and has a more rapid ABA-induced stomatal closure response than wild-type and atmyb44 knockout plants. Transgenic plants exhibited a reduced rate of water loss, as measured by the fresh-weight loss of detached shoots, and remarkably enhanced tolerance to drought and salt stress compared to wild-type plants. Microarray analysis and northern blots revealed that salt-induced activation of the genes that encode a group of serine/threonine protein phosphatases 2C (PP2Cs), such as ABI1, ABI2, AtPP2CA, HAB1, and HAB2, was diminished in transgenic plants overexpressing AtMYB44. By contrast, the atmyb44 knockout mutant line exhibited enhanced salt-induced expression of PP2C-encoding genes and reduced drought/salt stress tolerance compared to wild-type plants. Therefore, enhanced abiotic stress tolerance of transgenic Arabidopsis overexpressing AtMYB44 was conferred by reduced expression of genes encoding PP2Cs, which have been described as negative regulators of ABA signaling.