gebhart/patrepeval huggingface dataset:
ESR investigations of γ‐irradiated sulfur‐containing vinylpolymers (1974)

Abstract The formation and behaviour of radiation‐induced free radicals in statistical copolymers of ethoxyvinylthiomethane ( 1a ) with N ‐vinylpyrrolidone ( 2 ) (1:2,5) and of ethylthiovinylthiomethane ( 1b ) with 2 (1:3,5) has been studied using electron spin resonance spectroscopy. After a γ‐irradiation of the copolymers at 77K C α ‐radicals in the vinylpyrrolidone moieties could be detected. Investigations on the behaviour of these radicals with an annealing procedure revealed that only in the copolymer ( 3b ) with the dithioacetal group a transfer reaction of hydrogen atoms to the C α ‐radicals in the vinylpyrrolidone moieties occurs. This process may be regarded as a repair mechanism.
Dose-Dependent Effects of Focal Fractionated Irradiation on Secondary Malignant Neoplasms in <i>Nf1</i> Mutant Mice (2011)

Secondary malignant neoplasms (SMN) are increasingly common complications of cancer therapy that have proven difficult to model in mice. Clinical observations suggest that the development of SMN correlates with radiation dose; however, this relationship has not been investigated systematically. We developed a novel procedure for administering fractionated cranial irradiation (CI) and investigated the incidence and spectrum of cancer in control and heterozygous Nf1 mutant mice irradiated to a moderate (15 Gy) or high dose (30 Gy). Heterozygous Nf1 inactivation cooperated with CI to induce solid tumors and myeloid malignancies, with mice developing many of the most common SMNs found in human patients. CI-induced malignancies segregated according to radiation dose as Nf1(+/-) mice developed predominately hematologic abnormalities after 15 Gy, whereas solid tumors predominated at 30 Gy, suggesting that radiation dose thresholds exist for hematologic and nonhematologic cancers. Genetic and biochemical studies revealed discrete patterns of somatic Nf1 and Trp53 inactivation and we observed hyperactive Ras signaling in many radiation-induced solid tumors. This technique for administering focal fractionated irradiation will facilitate mechanistic and translational studies of SMNs.
Seroprevalence of Helicobacter pylori in primary Sjögren's syndrome. (2002)

Swedish patients with primary SS do not have higher H. pylori seroprevalence rates than controls. Neither was H. pylori seropositivity associated with the presence of immunological markers of SS such as circulating autoantibodies or a lip biopsy with abnormal focus score.
Corrosion Casting in the Reproduction of the Microsurface Topography of Fibrillar Collagen (1999)

: We have used a two-step casting procedure to create replicas of fibrillar collagen. A negative replica or mold is first created using either Mercox casting resin or a prepolymerized methacrylate resin that was originally described by Murakami. In the second step, a positive replica is made from the first using a solution of polystyrene or polyurethane to coat the methacrylate cast. The resulting replica is removed from the methacrylate cast. Results indicate the highest level of spatial resolution is obtained using a modified Murakami resin for the negative cast and polystyrene for the positive replica. The 29-nm-wide repeat banding structure present on collagen fibrils could be clearly identified in both the methacrylate cast and in the polystyrene positive replica of the methacrylate cast. Thus high-resolution replicas can be obtained. Such replicas may be useful to imprint inplantable devices with biologically relevant textures to improve tissue integration or for the development of textured surfaces for the in vitro expansion of cultured cells.
Analytical Studies on the Seismic Response of Lead Rubber Base Isolated Bridges (1992)

Highlights of a study related to the response of base isolated bridges are presented. Four different analytical models are developed and used to evaluate the response of base isolated bridges. A comparison between the results of the models is presented.
WaveCNV: allele-specific copy number alterations in primary tumors and xenograft models from next-generation sequencing (2013)

Supplementary data are available at Bioinformatics online.
Proton Spin-Lattice Relaxation of p-alkoxybenzoic Acid Liquid Crystal Homologues (1989)

Abstract The homologues of the p-alkoxybenzoic acid liquid crystal series with eight, nine and fifteen CH2 groups in their tail sections were studied by NMR in solid and liquid crystalline phases. The proton relaxation rates T1 −1, T1× −1 and T1D −1 were measured and compared with the relaxation rates of the homologues of the same liquid crystal series with 3 to 10 carbon atoms in the alkyl tail. The analysis of the origin of proton spin relaxation is based on the assumption that, approximately, all homologues have the same order director fluctuation rate. This rate is determined experimentally for PDBA (10 CH2 groups in tail) from T1 dispersion and assumed equal in all other homologues. The derived molecular diffusion relaxation rate increases with increasing mass of the molecules and when temperature is lowered. This rate also displays small oscillations with number of carbon atoms in the alkyl tail similar to the even-odd alternation of the melting temperature.
Editorial (2004)

Research Article| January 01 2004 Editorial Joseph Melnick Joseph Melnick Dr. Melnick, editor of Gestalt Review, has been practicing, teaching, and writing about Gestalt therapy for more than 30 years. He is a member of the professional staff of the Gestalt International Study Center and the Gestalt Institute of Cleveland. Search for other works by this author on: This Site Google Gestalt Review (2004) 8 (3): 255–259. https://doi.org/10.5325/gestaltreview.8.3.0255 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Permissions Cite Icon Cite Search Site Citation Joseph Melnick; Editorial. Gestalt Review 1 January 2004; 8 (3): 255–259. doi: https://doi.org/10.5325/gestaltreview.8.3.0255 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectivePenn State University PressGestalt Review Search Advanced Search The text of this article is only available as a PDF. Copyright © 2004 The Pennsylvania State University2004The Pennsylvania State University Article PDF first page preview Close Modal You do not currently have access to this content.
Correction- Electron-Deficient Trisubstituted Olefins (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleCorrection- Electron-Deficient Trisubstituted OlefinsH. K. Hall and Robert C. DalyCite this: Macromolecules 1975, 8, 6, 959Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/ma60048a055https://doi.org/10.1021/ma60048a055research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Two RFLPs in human inter-alpha-trypsin inhibitor heavy chain gene ITIH2 on chromosome 10 (1989)

Journal Article Two RFLPs in human inter-alpha-trypsin inhibitor heavy chain gene ITIH2 on chromosome 10 Get access T. Léveillard, T. Léveillard Institut National de la Santé et de la Recherche Medicale, INSERM Unitité 295, Faculte de Médecine-Pharmacie de RouenAvenue de I'Université, BP 97, 76803 St Etienne Rouvray Cédex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Bourguignon, J. Bourguignon Institut National de la Santé et de la Recherche Medicale, INSERM Unitité 295, Faculte de Médecine-Pharmacie de RouenAvenue de I'Université, BP 97, 76803 St Etienne Rouvray Cédex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J.P. Salier, J.P. Salier Institut National de la Santé et de la Recherche Medicale, INSERM Unitité 295, Faculte de Médecine-Pharmacie de RouenAvenue de I'Université, BP 97, 76803 St Etienne Rouvray Cédex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Diarra-Mehrpourr, M. Diarra-Mehrpourr Institut National de la Santé et de la Recherche Medicale, INSERM Unitité 295, Faculte de Médecine-Pharmacie de RouenAvenue de I'Université, BP 97, 76803 St Etienne Rouvray Cédex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Sesboäé, R. Sesboäé Institut National de la Santé et de la Recherche Medicale, INSERM Unitité 295, Faculte de Médecine-Pharmacie de RouenAvenue de I'Université, BP 97, 76803 St Etienne Rouvray Cédex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J.P. Martin J.P. Martin Institut National de la Santé et de la Recherche Medicale, INSERM Unitité 295, Faculte de Médecine-Pharmacie de RouenAvenue de I'Université, BP 97, 76803 St Etienne Rouvray Cédex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 13, 11 July 1989, Page 5418, https://doi.org/10.1093/nar/17.13.5418 Published: 11 July 1989
Anterior Occiput to Axis Screw Fixation (2003)

The anterior screw fixation technique was as effective as a posterior plate with transarticular screws in stabilizing between the occiput and C2 in axial rotation and lateral bending. In extension and flexion, the anterior screw technique was not as effective as a posterior plate with transarticular screws in providing stability.
The effect of small molecular inhibitors of CD4 on experimental allergic encephalomyelitis (1999)

Experimental allergic encephalomyelitis (EAE) in mice is a model for the human demyelinating disease, multiple sclerosis (MS). Studies in both EAE and MS demonstrated that CD4+ T cells have an important role in mediating the pathogenesis of disease. We have taken the approach to specifically inhibit the function of these autoreactive CD4+ T cells by disrupting the interaction between CD4 and the MHC class II molecule. A structure-base designed approach was used in which a synthetic peptide analog (802-2) of the D1CC′loop region of CD4 was developed and a small organic molecule (TJU103) was chosen by computer screening methods to specifically affect activated CD4+ T cells by disrupting the oligomerization and stabilization of the CD4-MHC class II interaction. These immunotherapeutics were tested for inhibitory activity in EAE. 802-2 and TJU103 when administered shortly before or after the onset of clinical symptoms significantly reduced the severity of disease in both the SJL and SWXJ-14 mouse models of EAE. In addition, long-term inhibitory activity of a single injection of 802-2 or TJU103 has been demonstrated in EAE rechallenge studies. In vitro and in vivo memory responses to proteolipid protein (PLP) were shown to be inhibited by these therapeutics. Studies with keyhole limpet hemocyanin (KLH), PLP, and alloantigen demonstrated that the inhibitors specifically affect only CD4+ T cells that are activated in the presence of either the 802-2 peptide or TJU103 organic molecule. Elispot analysis demonstrated a reduction in the frequency of antigen-specific cytokine-producing cells after in vivo 802-2 and TJU103 treatment. By utilizing a transgenic mouse model, the extent of inhibitory ability, as well as the mechanism of action of the therapeutics, was analyzed. TUNEL analysis suggested that apoptosis is the mechanism of action of both 802-2 and TJU103. These results indicate that CD4 inhibitors can reduce EAE severity and show potential for future clinical application.
Optimization of the barrier height in 1.3-μm InGaAsP multiple-quantum-well active regions for high-temperature operation (2001)

We present a study of barrier height effects on the high-temperature performance of 1.3 micron strained layer InGaAsP/InP quantum well lasers. Broad-area Fabry-Perot lasers were fabricated and their light-current characteristics were measured at temperatures between 20 degrees C and 80 degrees C. Based on our experimental results we analyze the effect of the barrier bandgap using the commercial laser simulation software LASTIP. The simulator calculates all relevant physical mechanisms, including their dependence on temperature and local carrier density, self-consistently. The strained quantum-well optical gain computation is based on the 4 x 4 kp method considering valence-band mixing effects. A drift-diffusion model including thermionic emission at hetero-interfaces is used for the calculation of the carrier transport. Careful adjustments of material parameters, in agreement with data reported in the literature, are performed in order to reproduce the measurements. Lowering the barrier height in the active region leads to an improved performance of our laser with respect to threshold current and slope efficiency. An optimum barrier bandgap range of 1.21 - 1.24 eV is identified for our laser. This is partially attributed to the non-uniform carrier-distribution across the quantum-wells.
Ventricular maps in 804 subjects correlate with cognitive decline, CSF pathology, and imminent Alzheimer's disease (2010)

There is an urgent need for neuroimaging biomarkers of Alzheimer's disease (AD) that correlate with cognitive decline, and with accepted measures of pathology detectable in cerebrospinal fluid (CSF). Ideal biomarkers should also be able to predict future decline, and should be computable automatically from hundreds to thousands of images without user intervention. Here we used our multi-atlas fluid image alignment method (MAFIA [1]), to automatically segment parametric 3D surface models of the lateral ventricles in brain MRI scans from 184 AD, 391 MCI, and 229 healthy elderly controls. Radial expansion of the ventricles, computed pointwise, was correlated with measures of (1) clinical decline, (2) pathology from CSF, and (3) future deterioration. Surface-based correlation maps were assessed using a cumulative distribution function method to rank influential covariates according to their effect sizes. The resulting approach is highly automated, and boosts the power of fluid image registration by integrating multiple independent registrations to reduce segmentation errors.
Étude comparative de<i>Centella asiatica</i>d'origine malgache et d'origine indienne (1997)

Summary A comparative study on différent lots of Centella asiatica, two from Madagascar (supplied by IMRA) and two from India, was performed. The HPLC analysis (High Performance Liquid Chromatography) of different lots of plant from Madagascar reveals a higher proportion of asiaticoside than the plant from India. Studies of the free radical scavenger potential and of the antielastase activity (in vitro test) show a more important activity for the extract of Centella asiatica from Madagascar.
Broadband Permittivity Measurements on Porous Planetary Soil Simulants, in Relation with the Rosetta Mission (2015)

International audience
Derivation of Major Yolk Proteins from Parental Vitellogenins and Alternative Processing During Oocyte Maturation in Fundulus heteroclitus1 (2005)

Various Coomassie blue-staining yolk proteins (YPs) present in oocytes and eggs of Fundulus heteroclitus, a teleost that produces low hydrated, demersal eggs (benthophil species), were subjected to N-terminal microsequencing. Four YPs were N-terminally blocked, while five yielded sequence information. Of the latter, four corresponded to internal sequences of vitellogenin 1 (Vg1), whereas a fifth band corresponded to the N-terminal sequence of Vg2. Phosphorylated YPs (phosvitins and phosvettes) derived from the polyserine domain of Vg were not successfully sequenced. The major N-terminally blocked 122-and 103-kDa YPs both represented the lipovitellin heavy chain of Vg1 (LvH1), and thus most of the oocyte YPs were derived from Vg1. During oocyte maturation in vivo and in vitro, the LvH1 122 is degraded, concomitant with an increased enzymatic activity of cathepsin B, while the 45-kDa YP is converted to a 42-kDa YP. The LvH1 122 was found to contain a consensus site for proteolytic degradation (PEST) near its C-terminus, which is missing from its stable, but truncated twin sequence, LvH1 103. We suggest that this site becomes exposed to cathepsin B during the hydration process that accompanies oocyte maturation and renders the LvH1 122 susceptible to proteolysis. PEST sites are found in Vg sequences from other benthophil fish, whereas, interestingly, they are missing in marine teleosts that spawn highly hydrated, pelagic eggs (pelagophil species), displaying a different pattern of Vg incorporation into YPs and LvH1 and LvH2 processing to that found in F. heteroclitus. Thus, different models of Vg/YP precursor/product relationship and further processing during oocyte maturation and hydration are proposed for pelagophil and benthophil teleosts.
Formation of disclination lines near a free nematic interface (1999)

We have studied the nucleation and the physical properties of a -1/2 wedge disclination line near the free surface of a confined nematic liquid crystal. The position of the disclination line has been related to the material parameters (elastic constants, anchoring energy, and favored anchoring angle of the molecules at the free surface). The use of a planar model for the structure of the director field (whose predictions have been contrasted to those of a fully three-dimensional model) has allowed us to relate the experimentally observed position of the disclination line to the relevant properties of the liquid crystals. In particular, we have been able to observe the collapse of the disclination line due to a temperature-induced anchoring-angle transition, which has allowed us to rule out the presence of a real disclination line near the nematic/isotropic front in directional growth experiments.
PK11195, A Specific Ligand of the Peripheral Benzodiazepine Receptor, May Protect Pancreatic Beta-cells from Cytokine-induced Cell Death (2011)

We cultured isolated islets from human or porcine origin in the presence or absence of IL1 and TNFα and studied cytoprotective effects of two structurally different PBR ligands. Storage of pig or human islets in the presence of cytokines significantly lowered the fraction of vital beta-cells. Compared with cytokine incubations PK11195 alone or in combination with cytokines was effective to prevent cytokine induced cell death. The data indicate that cold storage in the presence of PK11195 may further protect beta-cells from cytokine induced cell death. This ligand may be helpful to preserve beta-cell survival before transplantation.
ChemInform Abstract: VINCA ALKALOIDS PART 33, MICROBIOLOGICAL CONVERSIONS OF VINCALEUKOBLASTINE (VLB, VINBLASTINE), AN ANTITUMOR ALKALOID FROM VINCA ROSEA. LINN. (1974)

Abstract Bei der Behandlung der Titelverbindung (I) mit verschiedenen Streptomyces‐Arten wird der Äther (II) bzw. das Hydroxy‐Derivat (III) gebildet.
Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3-<i>d</i>]pyridine and Pyrazolo[3,4-<i>b</i>][1,8]naphthyridine Isosteres:  A New Class of Potent and Selective Acetylcholinesterase Inhibitors (2003)

A new family of tacrine (THA) analogues (7-9, 12), containing the azaheterocyclic pyrazolo[4,3-d]pyridine or pyrazolo[3,4-b][1,8]naphthyridine systems as isosteres of the quinoline ring of THA, has been synthesized. The compounds were tested in rat brain cholinesterases using Ellman's method, and all were fully efficacious in inhibiting the enzymes. Compounds 9 and 12b were the most potent against acetylcholinesterase (AChE), showing IC(50) of 6.0 and 6.4 microM, and were less active against rat brain butyrylcholinesterase, showing selectivity indexes of 5.3 and 20.9, respectively. Compounds 7-9 and 12 were also tested for their acute neurotoxicity in vitro, using cultured rat cortical cells. Compounds 7 and 8 were not significantly toxic; 9 was toxic at 500 microM, but not at 100 microM. The naphthyridine derivatives 12a and 12b showed a significant concentration-dependent neurotoxicity, being able to kill most cells at 500 microM. Molecular dynamic simulation using the X-ray crystal structure of AChE from Torpedo californica was used to explain the possible binding mode of these new THA isosteres.
Formation of metallic silver on silver-halide surfaces: Flash-photolysis experiments on silver-halide photochromic glasses (1979)

Optical and TEM measurements are reported on a series of well-characterized photochromic glasses containing silver-halide microparticles. The growth rate for formation of photolytic silver is found to vary inversely as some fractional power of the silver-halide particle diameter. Comparison with simple models suggests that in these experiments silver cluster growth is being limited by the motion of surface ions. This type of experiment may provide a model system for studying the mechanism of photographic latent-image formation.
Can Deep Learning Relax Endomicroscopy Hardware Miniaturization\n Requirements? (2018)

Confocal laser endomicroscopy (CLE) is a novel imaging modality that provides\nin vivo histological cross-sections of examined tissue. Recently, attempts have\nbeen made to develop miniaturized in vivo imaging devices, specifically\nconfocal laser microscopes, for both clinical and research applications.\nHowever, current implementations of miniature CLE components, such as confocal\nlenses, compromise image resolution, signal-to-noise ratio, or both, which\nnegatively impacts the utility of in vivo imaging. In this work, we demonstrate\nthat software-based techniques can be used to recover lost information due to\nendomicroscopy hardware miniaturization and reconstruct images of higher\nresolution. Particularly, a densely connected convolutional neural network is\nused to reconstruct a high-resolution CLE image from a low-resolution input. In\nthe proposed network, each layer is directly connected to all subsequent\nlayers, which results in an effective combination of low-level and high-level\nfeatures and efficient information flow throughout the network. To train and\nevaluate our network, we use a dataset of 181 high-resolution CLE images. Both\nquantitative and qualitative results indicate superiority of the proposed\nnetwork compared to traditional interpolation techniques and competing\nlearning-based methods. This work demonstrates that software-based\nsuper-resolution is a viable approach to compensate for loss of resolution due\nto endoscopic hardware miniaturization.\n