gebhart/patrepeval huggingface dataset:
Prediction of Quinolone Activity against <i>Mycobacterium avium</i> by Molecular Topology and Virtual Computational Screening (2000)

We conducted a quantitative structure-activity relationship study using a database of 158 quinolones previously tested against Mycobacterium avium-M. intracellulare complex in order to develop a model capable of predicting the activity of new quinolones against the M. avium-M. intracellulare complex in vitro. Topological indices were used as structural descriptors and were related to anti-M. avium-M. intracellulare complex activity by using the linear discriminant analysis (LDA) statistical technique. The discriminant equation thus obtained correctly classified 137 of the 158 quinolones, including 37 of a test group of 44 randomly chosen compounds. This model was then applied to 24 quinolones, including recently developed fluoroquinolones, whose MICs were subsequently determined in vitro by using the Alamar blue microplate assay; the biological results confirmed the model's predictions. The MICs of these 24 quinolones were then treated by multilinear regression (MLR) to establish a model capable of classifying them according to their in vitro activities. Using this model, a good correlation between measured and predicted MICs was found (r(2) = 0.88; r(2)(cv) [cross-validation correlation] = 0.82). Moxifloxacin, sparfloxacin, and gatifloxacin were the most potent against the M. avium- M. intracellulare complex, with MICs of 0.2, 0.4, and 0.9 microg/ml, respectively. Finally, virtual modifications of these three drugs were evaluated in LDA and MLR models in order to determine the importance of different substituents in their activity. We conclude that the combination of molecular-topology methods, LDA, and MLR provides an excellent tool for the design of new quinolone structures with enhanced activity.
Abstract LB-129: NDAT and P-bi-TAT formulations of tetraiodothyroacetic acid (tetrac) induce devascularization, necrosis and apoptosis in glioblastoma xenografts (2017)

Abstract Thyroid hormone as L-thyroxine (T4) has been reported to stimulate proliferation of multiple glioma cell lines in vitro and there is clinical evidence that medical induction of hypothyroidism slows growth of glioblastoma multiforme (GBM). The proliferative action of T4 on glioma cells is initiated at a cell surface receptor for thyroid hormone on the extracellular domain of integrin αvβ3. Tetraiodothyroacetic acid (tetrac) is a thyroid hormone (T4) derivative that blocks T4 action at αvβ3 and has anticancer and anti-angiogenic activity. Tetrac has been covalently bonded via a linker to a nanoparticle (Nanotetrac, Nano-diamino-tetrac, NDAT) or to two polyethylene glycol (PEG) molecules (P-bi-TAT) that increase the potency of tetrac and broadens the anticancer properties of the drug. In the present studies of U87 MG GBM xenografts, NDAT administered daily for 10 days s.c. as 1 mg tetrac equivalent/kg reduced tumor xenograft weight at animal sacrifice by 50%, compared to untreated control lesions (p &lt;0.01). Histopathological analysis of tumors revealed a 95% loss of the vascularity of treated tumors compared to controls at 10 days (p &lt;0.001). There was no intratumoral hemorrhage. There was extensive cellular necrosis in treated tumors attributable to devascularization. Cells not necrotic in treated xenografts exhibited apoptosis, so that 80% of cells were either necrotic or apoptotic, compared to controls (p &lt;0.001). Induction of apoptosis in cancer cells is a well-described quality of NDAT. P-bi-TAT treatment resulted in similar results after 20 days of treatment, but included a 21-day off-treatment follow-up after therapy. Xenografts achieved a 95% volume loss in the off-treatment, follow-up phase (P &lt; 0.001). In summary, systemic NDAT and P-bi-TAT have been shown to be effective by multiple mechanisms in treatment of GBM xenografts. Citation Format: Paul J. Davis, Sudha Thangirala, Stewart Sell, Aleck Hercbergs, Shaker A. Mousa. NDAT and P-bi-TAT formulations of tetraiodothyroacetic acid (tetrac) induce devascularization, necrosis and apoptosis in glioblastoma xenografts [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-129. doi:10.1158/1538-7445.AM2017-LB-129
Volumetric diffusers: Pseudorandom cylinder arrays on a periodic lattice (2010)

Most conventional diffusers take the form of a surface based treatment, and as a result can only operate in hemispherical space. Placing a diffuser in the volume of a room might provide greater efficiency by allowing scattering into the whole space. A periodic cylinder array (or sonic crystal) produces periodicity lobes and uneven scattering. Introducing defects into an array, by removing or varying the size of some of the cylinders, can enhance their diffusing abilities. This paper applies number theoretic concepts to create cylinder arrays that have more even scattering. Predictions using a boundary element method are compared to measurements to verify the model, and suitable metrics are adopted to evaluate performance. Arrangements with good aperiodic autocorrelation properties tend to produce the best results. At low frequency power is controlled by object size and at high frequency diffusion is dominated by lattice spacing and structural similarity. Consequently the operational bandwidth is rather small. By using sparse arrays and varying cylinder sizes, a wider bandwidth can be achieved.
Grapevine protection against Erysiphe necator by methyl jasmonate treatment- studies defense responses (2006)

National audience
An integrated approach for accurate simulation and modeling of the silicide-source/drain structure and the silicide-diffusion contact resistance (2002)

We present the first integrated simulation and modeling approach for the silicide-source/drain structure, and for the silicide-diffusion contact resistance; thus, providing the critical link between electrical performance and the processing/structural variables forming the silicide source/drain region. We apply this approach to predict the silicide-diffusion contact resistance accurately, and to improve transistor performance significantly.
The PanAmSat satellite system (1994)

PanAmSat was originally conceived of as a low-cost, high performance, means for providing satellite services between the U.S. and Latin America. The company quickly evolved to become a worldwide competitive alternative to Intelsat. The current system consists of a single satellite providing Cand Ku-band services for the United States, Latin America, and Europe since 1988. This system will be expanded, beginning in 1994, with the launch of the first of three additional satellites, to provide communications services on a global scale. This paper describes the present system, services provided, and procurement of the new satellites.
Photorefractive polymer device with video-rate response time operating at low voltages (2006)

The high-voltage bias required for video-rate compatible, efficient operation of a photorefractive polymer composite is reduced from 6-8 to 1.3 kV. At this low voltage, the device can hold erasable Bragg holograms with 80% efficiency in addition to having a video-rate response time. The transition of the hologram's state from thick to thin is analyzed in detail.
Regeneration of Pancreatic Non-β Endocrine Cells in Adult Mice following a Single Diabetes-Inducing Dose of Streptozotocin (2012)

The non-β endocrine cells in pancreatic islets play an essential counterpart and regulatory role to the insulin-producing β-cells in the regulation of blood-glucose homeostasis. While significant progress has been made towards the understanding of β-cell regeneration in adults, very little is known about the regeneration of the non-β endocrine cells such as glucagon-producing α-cells and somatostatin producing δ-cells. Previous studies have noted the increase of α-cell composition in diabetes patients and in animal models. It is thus our hypothesis that non-β-cells such as α-cells and δ-cells in adults can regenerate, and that the regeneration accelerates in diabetic conditions. To test this hypothesis, we examined islet cell composition in a streptozotocin (STZ)-induced diabetes mouse model in detail. Our data showed the number of α-cells in each islet increased following STZ-mediated β-cell destruction, peaked at Day 6, which was about 3 times that of normal islets. In addition, we found δ-cell numbers doubled by Day 6 following STZ treatment. These data suggest α- and δ-cell regeneration occurred rapidly following a single diabetes-inducing dose of STZ in mice. Using in vivo BrdU labeling techniques, we demonstrated α- and δ-cell regeneration involved cell proliferation. Co-staining of the islets with the proliferating cell marker Ki67 showed α- and δ-cells could replicate, suggesting self-duplication played a role in their regeneration. Furthermore, Pdx1(+)/Insulin(-) cells were detected following STZ treatment, indicating the involvement of endocrine progenitor cells in the regeneration of these non-β cells. This is further confirmed by the detection of Pdx1(+)/glucagon(+) cells and Pdx1(+)/somatostatin(+) cells following STZ treatment. Taken together, our study demonstrated adult α- and δ-cells could regenerate, and both self-duplication and regeneration from endocrine precursor cells were involved in their regeneration.
Maximum likelihood identification of power system dynamic equivalents (1974)

This paper presents a technique for identifying unknown parameters for a dynamic equivalent of a portion of an electric power system from on-line measurements made in another portion of the system. The resulting model is suitable for use in a standard transient stability program such as those used by system analysts for evaluating the security of a proposed or existing system. The method is based on stochastic system identification using the maximum likelihood technique and relies on natural system fluctuation. This paper describes the mathematical development of a maximum likelihood identifier for a dynamic model of a power system. The resulting identification program was tested using a simulated power system tuned to match measurements made on a real system.
Une remarque sur la trace de la torsion et le tenseur de Ricci (2009)

On donne une formule qui raccorde la trace de la torsion, le tenseur de Ricci et l’application exponentielle d’une connexion pour laquelle une forme volume est a dérivée covariante nulle. Ce résultat élémentaire répond a une question souvent posée.
Chemical Thermodynamics Consideration on Corrosion Products in Supercritical-Water-Cooled Reactor Coolant (2006)

In order to elucidate the dissolution/deposition behavior of corrosion products in supercritical-water–cooled reactor (SCWR) coolant, chemical thermodynamics calculation was carried out, taking into account the electrochemical properties of supercritical water. The review of thermodynamics models revealed the applicability of the modified HKF model for ionic species in the supercritical region. Using the calculation results, potential-pH diagrams were drawn for metal/water systems, which exhibited the effect of temperature and pressure on the stability of oxide in the SCWR core region.
RNA BASE RATIO CHANGES IN PLANARIA DURING CONDITIONING (1969)

Abstract— —Four groups of planaria were stimulated with light and shock: Group LAC received light systematically paired with shock delivered while the animal's head was oriented toward the cathode. Group LAA received light systematically paired with shock delivered while the animal's head was oriented toward the anode. Group L=C received light in random temporal relationship to cathodal head shock. Group L=C=A received light in random temporal relationship to randomized cathodal or anodal shock. Groups LAC animals acquired a conditioned flexion reflex in contrast to the other three groups. As each animal in Group LAC reached criterion, one animal which had received an equated amount of light and shock stimulation was selected from each of the other three groups. Each such set of four animals was fixed in Carnoy's solution and imbedded in paraffin. All subsequent analyses were run‘blind’in a different laboratory. Nerve cells from the head ganglion and from the tail were isolated with a micromanipulator after sectioning and pre‐treatment. RNA was extracted and base ratios determined by micro‐electrophoresis. The relationship of base ratio differences between groups to conditioning and stimulation is discussed.
Passive synchronization of repetition and offset frequency between two mode-locked Yb-doped fiber lasers (2011)

We have demonstrated an injection locking of mode-locked Yb-fiber oscillator seeded by another mode-locked pulse train. As well as the repetition rate, the offset frequency of the slave laser was locked passively.
<title>Use of dry-coupled ultrasonic inspection techniques for evaluation bondline quality</title> (1996)

Adhesive bonding has been used for many years to mechanically connect components to various structures. The quality of the adhesive bond is primarily dependent upon the strength of the adhesive and of the interface between the adhesive and the adherent. Further, the strength of the interface is dependent upon a number of parameters, such as the area of adherence, cleanliness of the interface, and cure of the adhesive. There is difficulty in evaluating these parameters and the associated quality of the adhesive bond because the adhesive layer is sandwiched between two adhesively bonded layers and is not accessible for visual inspection. A number of nondestructive evaluation (NDE) techniques have been developed to prove the adhesive bond to determine the status of these physical parameters Ultrasonics is one of the most often in the form of liquid. Many manufacturers of adhesively bonded joints would like to avoid the use of liquid in the presence of the bondline. This is especially true when the bonded materials are hygroscopic.
Characterizations of coatings obtained by dip coating from sol-gel suspensions (2009)

This research paper shows the conformation of coatings of the SiO2-TiO2-ZrO2system synthesized by the sol-gel method from Si(OC2H5)4, Ti(OBu)4 y Zr(OC3H7)4, which mean precursors, EtOH and water, and 2,4-pentanodione. They were deposited on stainless steel substrates AISI 304 by dip-coating in mono-layer, bi-layer and tri-layer. They were used as concentrations of the precursors Si 10% Ti 70% Zr 20% and Si 10% Ti 20% Zr 70%, which them conform the system. It was also studied the influence of the coatings on the anticorrosive behavior of the substrate in a solution of HCl to 3% by means of Electrochemical Impedance Spectroscopy (EIS) and power-dynamic curves of polarization. Additionally, it was carried out a study on adhesion of the coatings to the substrate and a study on micro-hardness of the system substratecoatings. It was also found that the values of the electrochemical parameters changed substantially with the number of layers deposited on the substrate.
Generating Realistic Dynamic Prices and Services for the Smart Grid (2014)

The smart grid promises to change the way people manage their energy needs, to facilitate the inclusion of small-scale renewable sources, and to open the energy market to all. One of the enabling instruments is the real-time pricing of energy at the retail level: dynamic and flexible tariffs will vary through the day to reflect the actual availability of energy and the congestion conditions of the power grid, in turn, helping the power grid to stay in balance. Current pilots and research efforts consider how such dynamic tariffs can be formed and how these will affect energy distribution and usage, although currently there are no instances of them deployed. To experiment with dynamic pricing, we present a vision and related implementation of the services needed by the end user to enable the smart grid in a smart home. Our system realistically simulates the dynamic prices and services of the smart grid, using data coming from wholesale energy markets and renewable installations. In addition, we perform an economic analysis to assess the cost of energy produced by small renewable-based installations. The aim is to offer a testing tool to easily realize large simulations, testbeds, and pilot projects for future energy distribution scenarios. We have tested the proposed services and dynamic pricing solution in an existing living laboratory, showing the feasibility of the approach and effectiveness of the tool.
Chemicopharmacological Studies on Antispasmodic Action. VII. Antagonism to Acetylcholine tested with Rectus Abdominis of Frog. (1957)

It was concluded statistically on the contraction of rectus abdominis of a frog that : 1) The reaction between ACh and its receptor in the muscle obeyed Clark's formula and the reaction order was 1, that is, they react with one molecule each. 2) Reaction mechanism between ACh and its receptor was different in the presence of eserine, from that in its absence. 3) Antagonism of atropine and d-tubocurarine to ACh obeyed Gaddum's formula as competitive. 4) One molecule of d-tubocurarine antagonized two mo■ecules of ACh ; two ammonium nitrogens in d-tubocurarine antagonized one molecule of ACh each.
Radiosurgery 1997 (1997)

This publication reflects the most current and exciting developments in the field of stereotactic radiosurgery today. It marks the second volume in the book series ‘Radiosurgery’, which is the official peer-reviewed publication of the International Stereotactic Radiosurgery Society. This latest volume includes long-term data on benign tumors, and e
Reference Governor for Constrained Systems with Time-varying References (2006)

This paper proposes a reference governor construction method for constrained linear systems with time-varying references. The main advantage of this reference governor is to simultaneously consider fulfillment of constraint conditions and evaluation of tracking performance. To derive a condition for constraint fulfillment we adopt a concept of maximal output admissible sets, and to evaluate tracking performance the management problem of time-varying references is reduced into a convex quadratic programming problem. Finally, the reference governor is obtained in the form of a piecewise affine function of state and reference variables, using a multi-parametric programming technique. In addition, we demonstrate the effectiveness of reference governors by a numerical example of a practical DC position servomechanism with control constraints
Synthesis of novel 2,8-disubstituted indolo[3,2-b]carbazoles (2011)

A new synthetic pathway towards 2,8-difunctionalised indolo[3,2-b]carbazoles was investigated. The presented method offers a short and high yielding route towards 2,8-dibromo-5,11-dihexyl-6,12-diphenyl-indolo[3,2-b]carbazole. It is demonstrated that the latter compound is a versatile building block, enabling the synthesis of a number of previously unreported 5,11-dialkyl-6,12-diphenyl-indolo[3,2-b]carbazoles in moderate to good yields, using Suzuki and Sonogashira cross-coupling reaction. Furthermore it is shown that 2,8-dibromo-5,11-dihexyl-6,12-diphenyl-indolo[3,2-b]carbazole can be easily formylated, giving rise to the 2,8-diformyl-5,11-dihexyl-6,12-diphenyl-indolo-[3,2-b]carbazole. The latter compound was successfully subjected to condensation reactions.
Gain spectroscopy in lnGaN/GaN quantum well diodes (2005)

Given the recent demonstration of a blue InGaN QW diode laser,1 one key question concerns the physical nature of optical gain in this system, given the rather high threshold current density required for lasing and the recognized presence of a complex crystalline microstructure in the material.
Babesia gibsoni infection among dogs in the southeastern United States (2002)

Results suggest that American Pit Bull Terriers in the southeastern United States may be subclinically infected with B. gibsoni. However, subclinical infection was not identified in dogs of other breeds from the same geographic area.
ONLINE DISTRIBUTED VEHICLE AND MACHINERY HEALTH MANAGEMENT (2003)

International Telemetering Conference Proceedings / October 20-23, 2003 / Riviera Hotel and Convention Center, Las Vegas, Nevada
Portosystemic communications: Follow‐up of 32 cases (1995)

ABSTRACT A multicentre retrospective study of dogs that underwent surgical attenuation of portosystemic communications (PSC) was conducted. These dogs were followed from three months after surgery to evaluate the long term effect of surgery on their life span, disease‐free interval, and owner assessment of postoperative quality of life of the dogs. Seventy‐five per cent of the dogs in this study had no long term postoperative recurrence of clinical signs. Of the 25 per cent of dogs that showed recurrent clinical signs, all but one had partial attenuation of the PSC. The location of the PSC was the only factor that correlated with whether the dogs were still alive. All owners were pleased with the postoperative quality of life of their dogs.
KLONOS: Similarity‐based planning tool support for porting scientific applications (2012)

SUMMARY In this paper, we propose a methodology to address an important aspect of software porting that receives little attention, namely planning support. When a scientific application consisting of many subroutines is to be ported, the selection of key subroutines greatly impacts the productivity and overall porting strategy because these subroutines may represent a significant feature of the code in terms of functionality, code structure, or performance. They may as well serve as indicators of the difficulty and amount of effort involved in porting a code to a new platform. The proposed methodology is based on the idea that a set of similar subroutines can be ported with similar strategies and result in a similar‐quality porting. By viewing subroutines as data and operator sequences, analogous to DNA sequences, we are able to use various bioinformatics techniques to conduct the similarity analysis of subroutines while mitigating NP‐complete challenges of other approaches. To the best of our knowledge, we are one of the first to explore this bio‐inspired view of program to target the porting planning problem. In this paper, we describe our methodology and present a tool called Klonos to facilitate the execution of the methodology, which integrates to well known bioinformatics tools. As a proof of concept, we use Klonos to conduct experiments to find strategies for porting of several scientific benchmarks and applications. We also have identified some of the advantages and limitations of the bio‐inspired view of a program code and the future work. Copyright © 2012 John Wiley & Sons, Ltd.
L4Android security framework on the Samsung galaxy S2 (2013)

There is a recent trend to use privately owned mobile devices in corporate environments. This poses serious threats on the security of corporate data. In this demo we show how we applied an efficient sandboxing mechanism to the Android software stack. This allows us to run multiple instances of Android securely isolated side-by-side on one device. We implemented a prototype on the Samsung Galaxy S2.