gebhart/patrepeval huggingface dataset:
Biological activity of the growth factor-induced cytokine N51: structure-function analysis using N51/Interleukin-8 chimeric molecules. (1994)

The immediate-early gene N51/KC encodes a protein which following expression in the baculovirus system and purification to apparent homogeneity is able to induce chemotaxis and intracellular Ca2+ flux, to compete for 125I-labeled interleukin-8 (IL-8) binding, and upon iodination, to bind specifically to human neutrophils. The activity of N51/KC can be distinguished from that of IL-8 by a number of criteria. First, at equivalent concentrations, the specific binding of [125I]N51/KC to human neutrophils is about 10 times less than that of [125I]IL-8. Second, the competition studies of [125I]IL-8 with IL-8 define a single class of high-affinity receptors, while the presence of both a high- and a low-affinity class of receptors is defined by N51/KC. Third, although the changes in intracellular Ca2+ of fura-2/AM-preloaded human neutrophils elicited by N51/KC and IL-8 are similar, pretreatment of the cells with N51/KC did not result in a loss of response to a subsequent treatment with IL-8; in contrast, treatment with IL-8 did result in the subsequent desensitization to N51/KC. To further characterize N51/KC, mutants and hybrids of N51/KC and IL-8 were produced and analyzed for the ability to compete for [125I]IL-8 binding and elicit intracellular Ca2+ changes in human neutrophils. Two important observations came from these studies. First, the N51/IL-8I hybrid in which the N51/KC sequence between cysteines 2 and 3 (or first disulfide bond) is replaced by the corresponding sequence in IL-8 shows IL-8-like properties, indicating that this region is important for specific receptor recognition. Second, the N51 delta III and IL-8 delta III C-terminus deletion mutants were biologically inactive, but the hybrid molecules N51/IL-8III and IL-8/N51III, in which the C termini were exchanged, had biological activities similar to that of the wild-type molecules, demonstrating that the presence of the C terminus is essential for the biological activity of these chemokines but does not confer receptor specificity.
Market vs. Limit Orders: The SuperDOT Evidence on Order Submission Strategy (1996)

Lawrence Harris, Joel Hasbrouck, Market vs. Limit Orders: The SuperDOT Evidence on Order Submission Strategy, The Journal of Financial and Quantitative Analysis, Vol. 31, No. 2 (Jun., 1996), pp. 213-231
One Voice Too Many: Adult Age Differences in Language Processing With Different Types of Distracting Sounds (1999)

An experiment is reported that investigated factors that might contribute to age differences in the ability to process spoken language under conditions of competition from various types of background noise. Age differences in recall of spoken sentences were shown to depend on the type of background noise as well as its intensity. Increased intensity levels of just one competing speaker produced differentially greater impairment in older adults than in young adults. Analyses showed that listening performance was predicted not only by individual differences in hearing ability but also by speed of processing, which underscores the combined role of age-related auditory and cognitive changes in processing spoken language.
Co-phasing of segmented telescopes: A new approach to piston measurements (2002)

One of the main problems arising in the co-phasing of segmented telescopes is the problem of measurements of the relative pistons among the segments. These measurements become especially complicated when the pistons are in order of wavelength fractions. In this paper we present a new approach relative piston measurements which allows for a high-accuracy reconstruction of small pistons. Our approach is based on the shearing interferometry and compared to existed methods it has the following advantages: a high accuracy of piston reconstruction in presence of high levels of noise is combined with the ability to retrieve the pistons taking into account the segment's aberrations.
The MPS1 Family of Protein Kinases (2012)

MPS1 protein kinases are found widely, but not ubiquitously, in eukaryotes. This family of potentially dual-specific protein kinases is among several that regulate a number of steps of mitosis. The most widely conserved MPS1 kinase functions involve activities at the kinetochore in both the chromosome attachment and the spindle checkpoint. MPS1 kinases also function at centrosomes. Beyond mitosis, MPS1 kinases have been implicated in development, cytokinesis, and several different signaling pathways. Family members are identified by virtue of a conserved C-terminal kinase domain, though the N-terminal domain is quite divergent. The kinase domain of the human enzyme has been crystallized, revealing an unusual ATP-binding pocket. The activity, level, and subcellular localization of Mps1 family members are tightly regulated during cell-cycle progression. The mitotic functions of Mps1 kinases and their overexpression in some tumors have prompted the identification of Mps1 inhibitors and their active development as anticancer drugs.
An ion-sense engine fine-tuner (1998)

The paper presents a real-time closed loop demonstration of spark advance control by interpretation of ionization current signals. Such control is shown to be able to handle variations in air humidity, which is a major factor influencing burn rates, and consequently pressure buildup and useful work transferred via piston to drive shaft. This leads to a clear improvement in engine efficiency compared to traditional systems using only engine speed and load. Inspired by the type of challenges and potential usefulness in interpretation of ionization current signals, the paper focuses on closed loop ignition control by ionization current interpretation. The topics discussed include: the basics of ionization currents; spark advance control, especially principles relating pressure information to efficiency; and the structure of the ion-sense spark advance controller. The experimental demonstrations and some conclusions are presented.
A Sub-1V Low Power V-Band CMOS VCO With Self-Body-Bias (2007)

This paper presents an integrated sub-1V low power millimeter-wave CMOS voltage-controlled-oscillator (VCO). The VCO was fabricated with the commercial 1P6M 0.18mum CMOS technology. To reduce the power consumption, the self-body-bias scheme was used in the VCO design. Operated at 0.7V, the VCO circuitry consumes 2.1 mW of power. The total chip size is 0.83mm times 0.35mm. The VCO tuning range covers from 52.2 GHz to 52.8 GHz and the corresponding K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">vco</sub> is 860 MHz/V. The measured phase noise at 1-MHz offset from 52.2 GHz is -95 dBc/Hz, which leads to an excellent figure-of-merit (FOM) of -186 dBc/Hz.
Data Mining Classification Algorithms for Kidney Disease Prediction (2015)

Data mining is a non-trivial process of categorizing valid, novel, potentially useful and ultimately understandable patterns in data. In terms, it accurately state as the extraction of information from a huge database. Data mining is a vital role in several applications such as business organizations, educational institutions, government sectors, health care industry, scientific and engineering. . In the health care industry, the data mining is predominantly used for disease prediction. Enormous data mining techniques are existing for predicting diseases namely classification, clustering, association rules, summarizations, regression and etc. The main objective of this research work is to predict kidney diseases using classification algorithms such as Nave Bayes and Support Vector Machine. This research work mainly focused on finding the best classification algorithm based on the classification accuracy and execution time performance factors. From the experimental results it is observed that the performance of the SVM is better than the Naive Bayes classifier algorithm.
<i>KRAS</i>Mutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing (2014)

Direct sequencing can accurately detect mutations, but, it is not always possible to obtain a tumor sample with sufficient volume. The PNA-mediated PCR clamping can rapidly provide results with sufficient sensitivity.
Characterization of immunogenic properties of haptenated liposomal model membranes in mice. I. Thymus independence of the antigen. (1979)

This paper describes a rather simple coupling method for tripeptide enlarged haptens to phosphatidylethanolamine (PE) and the incorporation of these conjugates into liposomal model membranes (haptenated liposomes). These haptenated liposomes evoke a hapten-specific humoral immune response in mice. The magnitude of the response as measured by the appearance of direct plaque forming cells in the spleen is dependent on the route of immunization and the dose and epitope density of the hapten-PE derivatives. It was not possible to evoke an IgG response after either primary or secondary immunization with haptenated liposomes (as measured by the production of indirect plaques or mercaptoethanol-resistant antibody). These data, in addition to the observations that mice depleted of, or deficient in thymus-derived (T) lymphocytes respond to haptenated liposomes, indicate that these haptenated liposomes are T-cell independent antigens.
Alteration in the Phosphatidylcholine Biosynthesis of Rat Liver Microsomes Caused by Vitamin B<sub>6</sub>Deficiency (1995)

Rats fed with a vitamin B6-deficient 70% casein diet for 5 weeks were found to have decreased considerably in the content of phosphatidylcholine (PC) in liver microsomes, presumably because of the depressed PC biosynthesis from choline or phosphatidylethanolamine (PE). The activities of choline phosphokinase and choline phosphotransferase in liver decreased, apparently, as compared with the pair-fed control or control rats. The hepatic level of the PE methyltransferase co-substrate, S-adenosylmethionine (SAM), decreased about 1/3, but the level of the inhibitory metabolite, S-adenosylhomocysteine (SAH), was elevated due to the marked reduction in the activities of cystathionine beta-synthase and gamma-cystathionase. The resultant molar ratio of SAM/SAH decreased drastically such that the methylation of PE to PC was decreased in vivo, as confirmed by lowering the activity of PE methyltransferase in vitro in response to a decreased molar ratio of SAM/SAH. A similar effect on the PE methylation was also observed in the pair-fed control rats, but the PC biosynthesis from choline clearly compensated for the drop of PC biosynthesis from PE. Results of this study demonstrate that vitamin B6 deficiency modified methionine metabolism and decreased choline utilization, and thus indirectly affected the biosynthesis of PC in liver microsomes.
<title>Fabrication And Evaluation Of A Monolithic InSb CID</title> (1980)

The fabrication of a monolithic indium-antimonide 32 x 32 CID array applicable for staring infrared imaging sensors is presented with preliminary characterization results. The basic MIS technology utilizes low-temperature CVD to deposit insulating layers of nitrogen-doped Si0<sub>2</sub> on bulk indium-antimonide substrates. A two-level insulator/two-level metal structure results in a simple four-mask process flow for the CID array. Completed arrays demonstrate acceptable dark currents that result in 20 ms storage times at 77K and are completely photocurrent dominated for typical tactical background photon flux densities in the 10<sup>15</sup> to 10<sup>16</sup> photons/cm<sup>2</sup>s range. Charge transfer experiments indicate acceptable transfer efficiencies for CID operation. Plans to demonstrate thermal imagery are presented.
Modeling of dynamics of industrial robots with flexible electric drives (2002)

Robot manipulators have greatly enhanced the performance of automated processes during the last decades. Industrial competition, however, creates an increasing demand to further improve the accuracy of off-line programming. Validated dynamic robot models are required for this purpose. We describe the development of a generic dynamic model which includes centrifugal, gravitational and Coriolis forces, motor dynamics, joint elasticities, etc., and specialize it to an actual industrial robot-KUKA IR 761. Time-optimal control is used in our computations for the rigid model of the manipulator performing a real life transport maneuver. The compliant vibrations of the overall robot model exhibited by time-optimal piecewise control are analyzed.
Kinetics and mechanism of the cytochrome c – sulfite reaction (1991)

The reaction between the oxidized form of horse-heart cytochrome c and sodium sulfite in aqueous solution has been studied in the pH range 6.5 – 8.2. The reaction is first order in both oxidant and reductant, is accelerated by an increase in pH and is slowed down by addition of potassium chloride. An increase in pH results in an increase in the apparent activation energy (66-77kJ . mol -1 ). A mechanism in which both HSO 3 - and SO 3 2- act as reducing agents is proposed, the activation energies corresponding to the cyt c-HSO 3 - and cyt c-SO 3 2- reactions being 63 ± 4 and 79 ± 2 kJ mol -1 , respectively.
Predictability of US tornado outbreak seasons using ENSO and northern hemisphere geopotential height variability (2015)

The predictability of dangerous atmospheric phenomena such as tornado outbreaks has generally been limited to a week or less. However, recent work has demonstrated the importance of the Rossby wavetrain phasing over the United States in establishing outbreak-favorable environments. The predictability of Rossby wavetrain phasing is strongly related to numerous climate-scale interannual variability indices, which are predictable many months in advance. To formalize the relationship between interannual variability indices and seasonal tornado outbreak frequency, indices derived from monthly mean Northern Hemisphere 500-hPa and 1000-hPa geopotential height fields and Niño 3.4 indices for ENSO phase were compared to annual tornado outbreak seasonal frequencies. Statistical models predicting seasonal outbreak frequency were established using linear (stepwise multivariate linear regression–SMLR) and nonlinear (support vector regression–SVR) statistical modeling techniques.\nThe stepwise methodology revealed predictors that are important in establishing outbreak-favorable environments at long lead times. Additionally, the results of the statistical modeling revealed that the nonlinear SVR technique reduced root mean square errors produced by the control SMLR technique by 28% and provided more consistent forecasts. A preliminary physical analysis revealed that years with high outbreak frequencies were associated with the presence of 500-mb troughs over the central and western US during the peak of outbreak season, while lower frequencies were consistent with ridging over the US or northwest flow over the Plains. These patterns support the results of the statistical modeling, which demonstrate the utility of geopotential height variability as a predictability measure of outbreak frequency.
Rural Parents Perceptions and Values and How They May Contribute to a More Contextually Based Early Childhood Program (1997)

The preservice training of early childhood professionals prepares teachers to work with young children, but rarely does it incorporate aspects of rural education nor is it specifically designed to prepare graduates for work in rural communities (Higgins, 1993; Bloodsworth, 1994; Kirk, 1994). Many of the initial employment opportunities available to graduates exist in rural areas. How well prepared are these generically trained teachers to undertake work in rural early childhood services? Are there aspects to rural communities that differ from urban contexts? This study investigates the perceptions and values of parents accessing a rural early childhood service. It attempts to illuminate what values are held by parents that could impact on how programs are developed, what expectations they have for their child in this service and in education generally. It would seem that there are distinctive and consistent values that could influence program design and delivery as well as implications for tertiary institutions in the way they train preservice teachers for work in rural communities.
Crystalline Structure and Electrical Properties of YCu<sub>x</sub>Mn<sub>1‐x</sub>O<sub>3</sub> Solid Solutions. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Thermal lens-circular dichroism detector for high-performance liquid chromatography (1990)

A novel and ultrasensitive chiral detector for high-performance liquid chromatography has been developed. This detector is based on the measurement of circular dichroism of chiral effluents by the thermal lens effect. In this instrument, the chromatographic effluent was sequentially excited by left circularly polarized laser light (LCPL) and right circularly polarized laser light (RCPL); both of these excitation beams were derived from the same argon ion laser whose linearly polarized output was transformed into circularly polarized light by means of a Pockels cell. The heat generated as a consequence of the sample absorption of the LCPL and RCPL was measured by the probe laser beam collinearly overlapping with the two excitation beams. A lock-in amplifier was used to measure the thermal lens-circular dichroism (TL-CD) signal which corresponds to the difference in the thermal lens signals produced by the LCPL and RCPL excitation beams. In addition to its high sensitivity, the advantages of this TL-CD chiral detector include its ability to provide, directly and in real time, information on the chirality (i.e., circular dichroism) and optical purity of chiral samples. A detection limit of 7.2 ng was achieved for (-)-tris(ethylenediamine)cobalt(III) (k' = 0.45) as well as for the (+)-tris(ethylenediamine)cobalt(III) (k' = 1.40) when these two enantiomers were chromatographically separated from the corresponding racemic mixture through the use of bis(mu-d-tartrato)diantiomonate(III) ion pair reversed-phase chromatography. This limit of detection was found by using a 10-microL flow cell and having 5-mm path length and 6-mW excitation laser beam (lambda = 514.5 nm) modulated at 2 Hz.
20 YEARS OF CLINICAL OPERATION WITH THE FAST NEUTRON THERAPY SYSTEM IN SEATTLE (2003)

The Clinical Neutron Therapy System at the University of Washington Medical Center in Seattle has now treated patients with fast neutrons for 20 years. During the past three years roughly 75 % of the treatments were for salivary gland tumors, where neutron therapy is the treatment of choice. After the installation of a small dedicated cyclotron in the Nuclear Medicine department for PET isotope production this service is no longer required from the Scanditronix MC50 cyclotron. Instead, a new beam line has been added for the production of 211-At using an alpha beam. The clinical operation remains very reliable with an 18 month time period where not a single patient session had to be cancelled for machine reasons. During the same time period all major system components were secured seismically, which required considerable construction activity during weekends with normal therapy operation continuing during the week. Besides the continuing upgrade and replacement of system parts a program is under way to migrate the accelerator / beam line controls to an EPICS based control system.
Video Coding for Machines: A Paradigm of Collaborative Compression and Intelligent Analytics (2020)

Video coding, which targets to compress and reconstruct the whole frame, and feature compression, which only preserves and transmits the most critical information, stand at two ends of the scale. That is, one is with compactness and efficiency to serve for machine vision, and the other is with full fidelity, bowing to human perception. The recent endeavors in imminent trends of video compression, e.g. deep learning based coding tools and end-to-end image/video coding, and MPEG-7 compact feature descriptor standards, i.e. Compact Descriptors for Visual Search and Compact Descriptors for Video Analysis, promote the sustainable and fast development in their own directions, respectively. In this paper, thanks to booming AI technology, e.g. prediction and generation models, we carry out exploration in the new area, Video Coding for Machines (VCM), arising from the emerging MPEG standardization efforts1. Towards collaborative compression and intelligent analytics, VCM attempts to bridge the gap between feature coding for machine vision and video coding for human vision. Aligning with the rising Analyze then Compress instance Digital Retina, the definition, formulation, and paradigm of VCM are given first. Meanwhile, we systematically review state-of-the-art techniques in video compression and feature compression from the unique perspective of MPEG standardization, which provides the academic and industrial evidence to realize the collaborative compression of video and feature streams in a broad range of AI applications. Finally, we come up with potential VCM solutions, and the preliminary results have demonstrated the performance and efficiency gains. Further direction is discussed as well.
Mayo clinic practice of cardiology (1997)

simultaneously, the editors build appropriate bridges between the basic sciences and clinical cardiology; the book takes a fresh look at a wide range of cardiac topics that are of primary interest to the clinical cardiologist. These include diagnostic and therapeutic modalities, preventive cardiology, myocar-
A group-based security protocol for Machine Type Communications in LTE-Advanced (2014)

We propose Authentication and Key Agreement (AKA) for Machine Type Communications (MTC) in LTE-Advanced. This protocol is based on an idea of grouping devices so that it would reduce signaling congestion in the access network and overload on the single authentication server. We verified that this protocol is designed to be secure against many attacks by using a software verification tool. Furthermore, performance evaluation suggests that this protocol is efficient with respect to authentication overhead and handover delay.
Identification of a Novel Metabolite in the Degradation of Pyrene by <i>Mycobacterium</i> sp. Strain AP1: Actions of the Isolate on Two- and Three-Ring Polycyclic Aromatic Hydrocarbons (2001)

Mycobacterium sp. strain AP1 grew with pyrene as a sole source of carbon and energy. The identification of metabolites accumulating during growth suggests that this strain initiates its attack on pyrene by either monooxygenation or dioxygenation at its C-4, C-5 positions to give trans- or cis-4,5-dihydroxy-4,5-dihydropyrene, respectively. Dehydrogenation of the latter, ortho cleavage of the resulting diol to form phenanthrene 4,5-dicarboxylic acid, and subsequent decarboxylation to phenanthrene 4-carboxylic acid lead to degradation of the phenanthrene 4-carboxylic acid via phthalate. A novel metabolite identified as 6,6'-dihydroxy-2,2'-biphenyl dicarboxylic acid demonstrates a new branch in the pathway that involves the cleavage of both central rings of pyrene. In addition to pyrene, strain AP1 utilized hexadecane, phenanthrene, and fluoranthene for growth. Pyrene-grown cells oxidized the methylenic groups of fluorene and acenaphthene and catalyzed the dihydroxylation and ortho cleavage of one of the rings of naphthalene and phenanthrene to give 2-carboxycinnamic and diphenic acids, respectively. The catabolic versatility of strain AP1 and its use of ortho cleavage mechanisms during the degradation of polycyclic aromatic hydrocarbons (PAHs) give new insight into the role that pyrene-degrading bacterial strains may play in the environmental fate of PAH mixtures.