gebhart/patrepeval huggingface dataset:
Thymus-dependent in vivo suppression of IgE synthesis in a murine IgE-secreting hybridoma. (1987)

In previous studies we demonstrated that BALB/c mice bearing ascitic tumors of the IgE-secreting hybridoma B53 (epsilon, kappa, anti-dinitrophenyl) developed large numbers of Lyt-1-2+ Fc epsilon R(+) T lymphocytes (T cells with membrane Fc receptors) in response to the elevated serum IgE concentration. The development of Fc epsilon R(+) T lymphocytes was followed by a progressive decrease in the levels of serum IgE in spite of continued proliferation of the hybridoma cells. This sequence of events suggested that the IgE-secreting hybridoma triggered a suppressive immunoregulatory circuit of the host that inhibited IgE expression by the hybridoma cells. The present studies were undertaken to investigate the basis for the subsequent decline in serum IgE levels in mice with B53 tumors and to identify host factors that might be involved in this process. We observed that ascitic B53 cells recovered at increasing time points from BALB/c mice exhibited a selective decline in steady state levels and rates of synthesis of epsilon-heavy chain protein and mRNA. The expression of kappa-light chain protein and mRNA appeared relatively unchanged. The decrease in epsilon-heavy chain gene expression did not occur when B53 tumors were passaged in nu+/nu+ mice or in BALB/c mice depleted of Lyt-2+ cells (suppressor/cytotoxic cell lineage), but did occur in nu+/nu+ mice reconstituted with neonatal BALB/c thymus and in BALB/c mice depleted of L3T4+ cells (helper/inducer cell lineage). That Fc epsilon R(+) T lymphocytes were directly involved in the inhibition of IgE expression was supported by the earlier and more pronounced inhibition of B53 IgE in mice infused with Fc epsilon R(+) T lymphocytes. We conclude from these findings that: 1) the decline in serum IgE levels that occurs toward the end of each generation of in vivo passage of the B53 hybridoma is due to decreased production of IgE by the hybridoma cells, 2) the decreased production of IgE is due to a selective loss of epsilon mRNA expression, 3) the decrease production of IgE by B53 cells is dependent on the presence of Lyt-2+ cells, and 4) Fc epsilon R(+) T lymphocytes participate in the mechanism by which IgE production is suppressed.
Erosion waves: transverse instabilities and fingering (2005)

Two laboratory scale experiments of dry and under-water avalanches of non-cohesive granular materials are investigated. We trigger solitary waves and study the conditions under which the front is transversally stable. We show the existence of a linear instability followed by a coarsening dynamics and finally the onset of a fingering pattern. Due to the different operating conditions, both experiments strongly differ by the spatial and time scales involved. Nevertheless, the quantitative agreement between the stability diagram, the wavelengths selected and the avalanche morphology reveals a common scenario for an erosion/deposition process.
Lung IkB and NFkB with neutrophilia in vivo in a gram positive infection model (2006)

Gram-positive infections have increased over the past few years; unfortunately, our mechanistic knowledge of the related inflammatory processes remains incomplete. Transcription factor NFkB coordinates activation of many genes involved in host defense, and the IkB-NFkB cascade strongly recruits PMN in gram negative studies. To investigate the involvement of NFkB in a gram positive model, abdominal tissue cage infections were produced by a patient strain of TSST-producing S. aureus. Lungs were evaluated by histostain and laser scanning confocal microscopy to quantify IkB and NFkB. Their presence was compared to clinical infection markers. Following harvest at 1 week, lung sections were stained with anti- IkB or NFkB (Santa Cruz) followed by appropriate secondary antibodies tagged with FITC or Texas Red, and evaluated by confocal microscopy. Tissues/ fluids for clinical infection markers were collected at necropsy. Tissue TNF alpha averaged 300 pg/mL infected vs.74 in controls. Tissue cage fluid showed a single S. aureus strain, 109/mL. Lung H&E indicated granulocytic inflammatory infiltrate. Lung sections, seen by confocal microscopy double staining, showed that NFkB, normally bound to IkB in the cytoplasm, was released in bronchial epithelial cells, (34.2 stain intensity vs. 0 control). IkB was seen at high levels in the sub epithelial layer (36.1 intensity). The prominent PMN influx to lung seen with the distant gram positive infection may relate to IkB in the airway, as reported by the work of others. Our data demonstrated in vivo the processes suggested by lung cell culture, and provide a catalyst to investigations of these factors in the pathophysiology of inflammation. Funding: UMKC Med. internal
Survival Benefit of Repeat Liver Transplantation in the United States: A Serial MELD Analysis by Hepatitis C Status and Donor Risk Index (2014)

Survival benefit (SB) for first liver transplantation (LT) is favorable at Model for End-Stage Liver Disease (MELD)≥15. Herein, we identify the MELD threshold for SB from repeat liver transplantation (ReLT) by recipient hepatitis C virus (HCV) status and donor risk index (DRI). We analyzed lab MELD scores in new United Network for Organ Sharing registrants for ReLT from March 2002 to January 2010. Risk of ReLT graft failure≤1 year versus waitlist mortality was calculated using Cox regression, adjusting for recipient characteristics. Of 3057 ReLT candidates, 54% had HCV and 606 died while listed. There were 1985 ReLT recipients, 52% had HCV and 567 ReLT graft failures by 1 year. Unadjusted waitlist mortality and post-ReLT graft failure rates were 416 (95% confidence interval [CI] 384-450) and 375 (95% CI 345-407) per 1000 patient-years, respectively. Waitlist mortality was higher with increasing waitlist MELD (p<0.001). The MELD for SB from ReLT overall was 21 (21 in non-HCV and 24 in HCV patients). MELD for SB varied by DRI in HCV patients (MELD 21, 24 and 27 for low, medium and high DRI, respectively) but did not vary for non-HCV patients. Compared to first LT, ReLT requires a higher MELD threshold to achieve an SB resulting in a narrower therapeutic window to optimize the utility of scarce liver grafts.
Chiral coupling of a quantu m emitter in a topological photonic resonator (2020)

Here we demonstrate chiral light-matter interactions in a topological photonic crystal resonator. We achieve this by employing valley-Hall topological edge states to create a helical resonator at the interface of two topologically distinct regions.
Proximity Verification Based on Acoustic Room Impulse Response (2018)

Device proximity verification has a wide range of security applications such as proximity authentication, multi-factor authentication, group-membership management and many more. To achieve high ease-of-use, a recently proposed class of solutions exploit contextual information captured by onboard sensors including radio (Wi-Fi, Bluetooth and GPS receivers), ambient sounds (microphones), movement (accelerometers) and physical environment (light, temperature and humidity) to facilitate the verification process with minimal user involvement. Active acoustic methods have some advantages over many others: they work indoors, they can take the shape of the enclosure and barriers into account, they don't require pre-installed infrastructure and they are relatively fast. In this paper we propose R-Prox, an approach for proximity (copresence) verification based on acoustic Room Impulse Response (RIR). In R-Prox, one device actively emits a short, wide-band audible chirp and all participating devices record reflections of the chirp from the surrounding environment. From this impulse response signal, we extract features on different frequency bands and compare them for a copresence verdict. We evaluate our method by collecting RIR data with various Commercial Off-The-Shelf (COTS) mobile devices in different rooms. We then train a binary classification model to determine copresence using RIR features. In our experiments we show R-Prox to be sensitive, with false negative verdicts can be as low as 0.059 of the true copresence cases. Although R-Prox's false positive rate is not as low (in case rooms are likely having similar acoustic RIR), we show that it can be effectively combined with schemes like Sound-Proof (which suffers from high false positive rates in some adversarial settings) so that the resulting system has high accuracy.
Macrocyclic carbonyl compounds as structural models of natural ion carriers (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMacrocyclic carbonyl compounds as structural models of natural ion carriersAbraham Shanzer, Jacqueline Libman, and Felix FrolowCite this: Acc. Chem. Res. 1983, 16, 2, 60–67Publication Date (Print):February 1, 1983Publication History Published online1 May 2002Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/ar00086a005https://doi.org/10.1021/ar00086a005research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A kernel regression based resolution enhancement technique for low resolution video (2010)

Super-resolution enhancement is the technique of increasing spatial resolution of an image from the image itself or from several noisy images of the same scene but with additional information such as motion. This paper presents a kernel regression approach to reconstruct a high resolution image from several low resolution video frames. In many applications including cell phone and webcam the imaging sensors capture low resolution images due to low cost sensors or physical limitation of the hardware. So, the proposed resolution enhancement technique could be used as an inexpensive software alternative. The performance of the proposed algorithm is evaluated with several grayscale and color video streams and found successful when compared to other state of the art techniques.
Vector spaces and signal space (2008)

In Chapter 4, we showed that any ℒ2 function u(t) can be expanded in various orthogonal expansions, using such sets of orthogonal functions as the T-spaced truncated sinusoids or the sinc-weighted sinusoids. Thus u(t) may be specified (up to ℒ2-equivalence) by a countably infinite sequence such as {uk,m; −∞ < k, m < ∞} of coefficients in such an expansion.
Linux Server Performance Tuning (2005)

Proven techniques for optimizing web, file, print, database, and application servers Practical introductions to open source performance management tools Easy-to-understand examples based on Red Hat Enterprise Linux and Novell SUSE Linux Enterprise ServerAn indispensable guide to maximizing Linux system and application performanceFrom Wall Street to Hollywood, Linux runs many of the world's most businesscritical systems. Linux performance now impacts the entire enterprise. In Performance Tuning for Linux Servers, a team of IBM's most-experienced Linux performance specialists shows you how to find bottlenecks, measure performance, and identify effective optimizations.This book doesn't just cover kernel tuning: it shows how to maximize the end-to-end performance of real-world applications and databases running on Linux. Throughout, the authors present realistic examples based on today's most popular enterprise Linux platforms, Intel-based Red Hat Enterprise Linux, and Novell SUSE Linux Enterprise Server. These examples are designed for simplicity, clarity, and easy adaptation to any contemporary Linux environment. You'll discover how to Install and configure Linux for maximum performance from the outset Evaluate and choose the right hardware architecture for your Linux environment Understand Linux kernels 2.4 through 2.6: components, performance issues, and optimization opportunities Master core Linux performance tuning principles and strategies Utilize free, open source tools for measurement, monitoring, system tracing, and benchmarking Interpret performance data to analyze your Linux server's real-world behavior Optimize Linux system schedulers, memory, I/O, file systems, and networking Tune web, file, database, and application servers running commercial workloads Predict the impact of changes in tuning parameters or configurations Tune Linux code: optimize design, timing, sockets, threads, synchronization, and more Architect for maximum performance: SMP scaling, clustering, and topology Integrate kernel and application tuning in end-to-end system optimization projectsWhether you're an administrator, developer, integrator, or consultant, Performance Tuning for Linux Serverswill help you maximize the performance and value of every Linux system and application you run.© Copyright Pearson Education. All rights reserved.
FLAP: 4‐Point Pharmacophore Fingerprints from GRID (2005)

This chapter contains sections titled: Introduction Pharmacophores and Pharmacophore Fingerprints FLAP FLAP Theory Docking GLUE: A New Docking Program Based on Pharmacophores Case Study Structure Based Virtual Screening (SBVS) Ligand Based Virtual Screening (LBVS) Protein Similarity TOPP (Triplets of Pharmacophoric Points) Conclusions
Area per Ligand as a Function of Nanoparticle Radius: A Theoretical and Computer Simulation Approach (2009)

Inorganic nanoparticles (NPs) display unique size-dependent properties and have applications in many different areas such as medicine and the semiconductor industry. In order to take advantage of these properties, the organization of the NPs must be controlled, either to promote crystallization or to prevent agglomeration. This control is typically acheived by using covalently bound amphiphilic ligands. While the properties of the NPs themselves have been well-characterized, much less is known about the organic ligand coating. Here, we present a theoretical and computer simulation approach to compute the surface area occupied per ligand molecule as a function of the NP radius and of the ligand hydrophilic to lipophilic balance. We employ a self-consistent method which takes into account the full free energy of the NP/ligand/solvent system, which for this study is composed of hydrophobic NPs, alkyl poly(oxyethylene) ligands, and water. We find an order of magnitude higher ligand coverage on NPs compared to flat surfaces, in agreement with some experimental reports. Our approach is fundamentally different from existing computational methods in the literature and builds a foundation for studies of the organization of colloidal NPs in solvents or at interfaces.
ChemInform Abstract: Remarkably Selective Palladium‐Catalyzed Amination Process: Rapid Assembly of Multiamino Based Structures. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Estrogen-induced Production of a Peroxisome Proliferator-activated Receptor (PPAR) Ligand in a PPARγ-expressing Tissue (1998)

Peroxisome proliferation has been associated with carcinogenesis in the liver, and estrogen intake has been associated with increased risk of cancer in the hormone target tissues. Estrogen-induced peroxisome proliferation has been observed in an estrogen target tissue, the uropygial gland in the duck. To elucidate the molecular mechanism of this process, we previously isolated the cDNA of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) from the duck uropygial gland and found that its expression was high exclusively in this tissue of duck. However, the nature of the ligand for PPARgamma1 and how estrogen might enhance PPARgamma1-regulated gene expression were not known. Here we demonstrate that estrogen treatment of animals enhanced the metabolism of arachidonic acid in the uropygial gland. Conversion of prostaglandin D2 to a metabolite was induced by estradiol treatment preceding peroxisome proliferation. High performance liquid chromatography and TLC analyses showed that the metabolite behaved chromatographically similar to prostaglandin J2 and Delta12-prostaglandin J2. Gas chromatography/mass spectrometry revealed a striking similarity of the metabolite to Delta12-prostaglandin J2, the only form among the J2 series whose natural occurrence has been detected. Furthermore, this metabolite was able to activate duck PPARgamma1 to the same extent as the same concentrations of Delta12-prostaglandin J2 and 15-deoxy-Delta12, 14-prostaglandin J2, whereas under the same conditions, prostaglandin D2 was not effective. The results suggest that estrogen treatment induced the formation of a prostaglandin D2 metabolite that activated duck PPARgamma1, causing the induction of peroxisome proliferation in the duck uropygial gland.
Internalization‐defective mutants of somatostatin receptor subtype 2 exert normal signaling functions in hematopoietic cells (2001)

The regulatory peptide somatostatin (SST) acts via a family of G-protein-coupled receptors comprising five subtypes (SSTR1-5). G-protein-coupled receptors activate multiple signaling mechanisms, which variably depend on internalization and intracellular routing of activated receptors. We have recently demonstrated that hematopoietic precursors express SSTR2 and that SST is a chemoattractant for these cells. Herein, we characterize critical regions in SSTR2 involved in endocytosis and describe how ligand-induced internalization impacts on two major signaling functions of SSTR2 in hematopoietic cells, the activation of the Erk pathway and the induction of promigratory responses.
Structurally characterized intermediates in the stepwise insertion of CO–ethylene or CO–methyl acrylate into the metal–carbon bond of Pd(<scp>ii</scp>) complexes stabilized by (phosphinomethyl)oxazoline ligands (2006)

The initial CO-ethylene or CO-methyl acrylate insertion steps into the Pd-Me bond of methylpalladium(II) complexes with (phosphinomethyl)oxazoline ligands, leading to metallacycles, have been fully characterized, including by X-ray diffraction.
NONLINEAR VIBRATIONS IN AN AGRICULTURAL IMPLEMENT SYSTEM (1994)

Vibrations in an agricultural implement system composed of a tractor and a subsoiler are analyzed from the viewpoint of nonlinear dynamics. The time series data of acceleration experimentally obtained are classified to chaotic and periodic vibrations with reconstruction of possible attractors and with deterministic nonlinear prediction.
Design of causal stable perfect reconstruction two-channel IIR filter banks (2002)

An efficient optimization algorithm is proposed for designing causal stable perfect-reconstruction two-channel infinite impulse response filter banks originally introduced by Basu, Chiang, and Choi. The problem is stated as a constrained optimization problem where the maximum of the stopband energies of the analysis filters is minimized subject to the given constraints. First, the maximum allowable passband ripple of both filters is fixed and the maximum value in the transition bands is the maximum allowable passband value. Second, the poles of these filters are forced to lie inside the unit circle. It is shown that the second constraint can be included in the proposed algorithm by using Rouche's theorem. Several examples are included illustrating the efficiency of the proposed design scheme as well as the superiority of the resulting banks compared to those obtainable by using other existing design techniques.
Analysis of circular horn antennas using the FD-TD method (2003)

Application of the vector two-dimensional FD-TD (finite-difference time-domain) method to the analysis of circular horn antennas is presented. An antenna should maintain axial symmetry of boundary conditions and can be arbitrarily shaped in two other directions, in the cylindrical coordinate system. The medium filling the antenna can be inhomogeneous. Modes of excitation of sinusoidal dependence on angle can be considered. A full-wave solution is obtained. An example of a circular horn antenna has been computed and compared with experimental data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Endocrine disrupting chemicals in New Orleans surface waters and Mississippi Sound sediments (2012)

Endocrine disrupting compounds (EDCs), represented by steroid hormones, organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and bisphenol A have been determined in four sediment cores from the Gulf of Mexico, from New Orleans surface water (Lake Pontchartrain and Mississippi River), and from the influent and effluent of a New Orleans municipal sewage treatment plant. During the five-month monitoring of selected EDCs in the Mississippi River (MR) and Lake Pontchartrain (LP) in 2008, 21 of 29 OCPs in MR and 17 of 29 OCPs in LP were detected; bisphenol A was detected in all of the samples. Steroid hormones (estrone, 17β-estradiol and 17α-ethinylestradiol) were detected occasionally. Total EDC (OCPs + PCBs + steroid hormones + bisphenol A) concentrations in the two surface water samples were found to vary from 148 to 1112 ng L(-1). Strong correlation of the distribution of total OCPs, total PCBs and total EDCs between solid and water phases was found in LP, while moderate or no correlation existed in MR. OCPs, PCBs, steroid hormones, and bisphenol A were all detected in the ocean sediments, and total EDCs were measured in the range of 77 to 1796 ng g(-1) dry sediment weight. The EDCs were also found in untreated and treated municipal sewage samples with a removal efficiency of 83% for OCPs but no removal efficiency for 17α-ethinylestradiol.
Dual Frequency Ultrasonic Flowmeter (1987)

As to an ultrasonic flowmeter which deduces flowrate from the propagating time of ultrasonic pulse wave in the flow, it is very important to accurately detect the pulse wave reaching the ultrasonic transducer. In a conventional ultrasonic flowmeter, a constant threshold is set to detect a certain peak in the leading edge of the received pulse wave. But when the amplitude of the received pulse wave fluctuates due to a disturbance in the flow, ‘trigger-miss’ often happens as it is difficult to identify the same peak by a constant threshold.In the present study a new method has been developed to consistently detect the pulse wave even when there exists strong fluctuation. Two pairs of ultrasonic transducers are placed across the flow and transmit two waves of different frequencies simultaneously. These waves are received at the opposite side and are added together in an electric circuit to generate some predominant peaks at the leading edge of the pulse. Setting the threshold to one of the predominant peaks, detection of the pulse wave is much less affected by fluctuation of an amplitude of the received signal.A flowmeter using this method was constructed and tested. It has been proved that this method is effective to consistently measure propagating time in the disturbed flow compared with the conventional method using a single wave.