gebhart/patrepeval huggingface dataset:
ARTERIAL PRESSURE VARIABILITY FOR EVALUATION OF AUTONOMIC NERVOUS ACTIVITY OF PATIENTS WITH LEFT VENTRICULAR ASSIST DEVICE (2003)

Purpose: Arterial pressure variability (APV) is the power density values of pressure signals and high frequency (0.15 to 0.4 Hz) and low frequency (0.04 to 0.15 Hz) components of APV are regarded as the function of autonomic nervous system (ANS). APV was examined for evaluation of the ANS activity of patients with left ventrienlar assist device (LVAD). Methods: Arterial pressure signals were acquired every 2 hours at 100 Hz for 6 minitutes in patients in ICU. Power spectral analysis was carried out, and APV was observed in 3 patients with Zeon LVADs before their transfer for cardiac transplantation. For comparison, APV was also obsereved in 17 patients with IABP and/or PCPS. Results: The observation periods of 3 patients with LVADs were 15, 33 and 58 days respectively. The normalized power spectral component with low frequency (LFAnorm) was depressed initially and was gradually increased before their transfer. Although the value also gradually increased in 13 patients with LABP and/or PCPS, sustained low values of LFAnorm of APV in 4 patients were related to prolonged mechanical support, and 3 patients among them were expired consequently. Conclusion: Depressed LFAnorm of APV represented marked stress on ANS. The study results suggest that LVAD support exert a favorable effect on ANS in patients with severe heart failure before cardiac transplantation.
Alkyl Anhydronium Bases of Harmaline — A b-Carboline Alkaloid of Peganum harmala (1994)

This paper reports the synthesis of alkylanhydronium bases from harma- line on its reaction with different alkyl halides. There is no earlier procedure of formation of alkylharmaline with anhydronium skeleton, with these or any other reagent
High-power quantum cascade lasers grown by low-pressure metal organic vapor-phase epitaxy operating in continuous wave above 400K (2006)

High-power quantum cascade lasers (QCLs) working in continuous wave (cw) above 400K are presented. The material was grown by low-pressure metal organic vapor-phase epitaxy and processed into narrow buried heterostructure lasers. A cw output power of 204mW was obtained at 300K with an 8.38μm wavelength, 3mm long and 7.5μm wide coated laser. The device operates in cw mode above 400K, which exceeds the previous maximum cw temperature operation of QCLs by approximately 60K. Preliminary reliability data obtained by accelerated aging tests indicate a remarkable robustness of the lasers.
Aciditätsbestimmung mit Hilfe aliphatischer Diazoverbindungen. II. Die Aufstellung einer dynamischen Aciditätsreihe (1965)

Abstract Auf Grund der schon früher zur Messung von Säurestärken verwandten Geschwindigkeit der Säurezersetzung aliphatischer Diazoverbindungen wurde ein Aciditätsbestimmungsverfahren ausgearbeitet, das bei Verwendung mehrerer Diazoverbindungen abgestufter Säureempfindlichkeit einen bereits nahezu 10 Zehnerpotenzen breiten Aciditätsbereich lückenlos erfaßt. Die als Maß der Aciditätsdifferenz zweier Säuren dienenden Quotienten der Reaktionsgeschwindigkeitskonstanten sind innerhalb der Fehlergrenzen unabhängig von den jeweils zur Messung verwandten Diazoverbindungen, so daß eine rechnerische Eliminierung des Einflusses der letzteren und damit die Aufstellung einer eindeutigen Aciditätsreihe ermöglicht wird.
An Automated HPLC Method for the Assay of Propranolol and Its Basic Metabolites in Plasma and Urine (1982)

An automated HPLC method is described for the simultaneous determination of propranolol, 4-hydroxypropranolol, and N-desisopropylpropranolol in plasma and urine before and after beta-glucuronidase/aryl sulfatase treatment. It involves extraction with ether at pH 10 in the presence of ascorbic acid, added to prevent oxidation of 4-hydroxypropranolol. The compounds are then back extracted into dilute acid and assayed on an HPLC using a fluorescence detector. Three HPLC columns have been used (a phenyl, an octyl, and an octadecyl column). The last column was found to be most reproducible with minimal intercolumn variation. The solvent system includes a combination of acetonitrile, methanol, and phosphoric acid. Concentrations as low as 0.2, 1.0, and 0.2 ng/ml of propranolol, 4-hydroxypropranolol, and N-desisopropylpropranolol, respectively, can be measured using 1 ml of plasma.
High data-rate infra-red optical wireless communications: Implementation challenges (2010)

Achieving high data-rates in optical wireless involves theoretical limits and practical constraints. In this paper we discuss these, with reference to two system examples. A 1.25 Gigabit/s demonstrator that has been fabricated as part of the European Community Framework 7 project OMEGA is described, and a 280Mbit/s demonstrator that is currently under development as part of the same project. In each case the compromises required, and implementation issues are discussed.
Nonlinear Feedforward-Plus-PID Control for Electrohydraulic Steering Systems (1999)

Abstract This paper presents the development of a nonlinear feedforward-plus-Proportional-Integral-Derivative (FPID) controller for electrohydraulic (E/H) steering on wheel-type tractors. An E/H steering system is a typical nonlinear system with deadband, saturation, asymmetric flow gain, time delay, and other nonlinear behaviors. Conventional PID controllers are incapable of achieving accurate steering control effectively on such nonlinear systems. In this research, an FPID controller was developed for effective and accurate steering control. The feedforward loop in this controller was designed to compensate for the deadband of the E/H system. The PID loop was designed to compensate the tracking error in steering control. A coordinated nonlinear gain function was designed to change the PID loop gain based on the level of the tracking error. This FPID controller has significantly improved the steering accuracy comparing with that from a PID controller. Test results showed that the maximum tracking error in steering angle was less than 0.5° corresponding to a sinusoid steering command of ±5° at the command frequency of 0.1 Hz. The maximum overshoot was less than 12% and the rise time was less than 0.25 s corresponding to a steering command of 5° step input. This FPID controller achieved effective and accurate steering control on agricultural tractor E/H steering systems.
Stability and accuracy considerations in the design and implementation of a kilowatt-scale DC power hardware-in-the-loop platform (2014)

Power hardware-in-the-loop (PHIL) is a developing simulation technology for the virtual prototyping of electrical systems, wherein switching power converters are controlled to represent the dynamic behavior of a simulated system at their power terminals. PHIL allows for advanced studies to be performed on system interactions by virtually coupling a realtime software simulation of electrical components to a physical piece of hardware through the use of an interfacing amplifier and appropriate control algorithm. Special consideration must be made in the design of a PHIL test platform to ensure that the overall system remains stable in operation and yields accurate results for both the software simulated system and the interfaced hardware under test. The contributions of this paper include the implementation of a highly stable power interface control algorithm, development of impedance based design constraints for interface amplifier design, and accuracy and stability evaluation of a simulated PHIL test platform. The resulting test platform is assessed through the PHIL simulation of a representative kilowatt-scale MVDC distribution system.
Embodied Realistic Avatar System with Body Motions and Facial Expressions for Communication in Virtual Reality Applications (2020)

Providing effective communication in virtual reality (VR) applications requires body language and facial expressions to transmit users’ thoughts and behavior. Embodied VR is an effective way to realistically render users’ movements onto a virtual avatar in a virtual environment in real time. There are many VR applications that utilize this technique; however, most of them have limitations in photorealistic realism, body motion, and facial expressions. In this work, we introduce a novel VR communication system that mimics users’ movements, facial expressions, and speech in order to render these capture data into different types of avatar representations in real-time. This system could be beneficial for any type of VR application that requires avatar-based communication in a 3D immersive virtual environment.
Functional organization of the nucleus. A laboratory guide. (Methods in cell biology, vol. 35) (1992)

interest in this protein, which has been profitably investigated over the last few years.The other major focus in this section is on the u-PA gene and its expression in transgenie mice.The following four sections of the volume cover Endocrine Systems and Embryology.Dermatology and Inflammation, Fibrinolysis and Oneology.It is timely to present these areas in a single volume, which should encourage cross-fertilization between these related areas.Inevitably with a multi.authorwork, there is some unevenness in the level of expertise expected of the reader.Most chapters provide LETTERSSeptember 1992good introductions and will appeal to relative newcomers to the field.The book will also be useful to those working in one of these areas, wh0wish to broaden their knowledge of allied research.The Preface notes that the aim of the volume is to present information to 'biologists, oncologists, cardiologists, dermatologists, and endocrinologists'.The aim is generally achieved and this book complements more speeialised volumes on ;.he individual topics covered here.
An ACME Profile for Generating Delegated STAR Certificates (1998)

This memo proposes a profile of the ACME protocol that allows the
owner of an identifier (e.g., a domain name) to delegate to a third
party access to a certificate associated with said identifier. A
primary use case is that of a CDN (the third party) terminating TLS
sessions on behalf of a content provider (the owner of a domain name).
The presented mechanism allows the owner of the identifier to retain
control over the delegation and revoke it at any time by cancelling
the associated STAR certificate renewal with the ACME CA. Another key
property of this mechanism is it does not require any modification to
the deployed TLS ecosystem.
Functional Interactions between Tumor and Peripheral Nerve: Morphology, Algogen Identification, and Behavioral Characterization of a New Murine Model of Cancer Pain (2001)

This paper describes a model of tumor-induced bone destruction and hyperalgesia produced by implantation of fibrosarcoma cells into the mouse calcaneus bone. Histological examination indicates that tumor cells adhere to the bone edge as early as post-implantation day (PID) 3, but osteolysis does not begin until PID 6, correlating with the development of hyperalgesia. C3H/He mice exhibit a reproducible hyperalgesia to mechanical and cold stimuli between PID 6 and 16. These behaviors are present but significantly reduced with subcutaneous implantation that does not involve bone. Systemic administration of morphine (ED(50) 9.0 mg/kg) dose-dependently attenuated the mechanical hyperalgesia. In contrast, bone destruction and hypersensitivity were not evident in mice implanted with melanoma tumors or a paraffin mass of similar size. A novel microperfusion technique was used to identify elevated levels of the putative algogen endothelin (ET) in perfusates collected from the tumor sites of hyperalgesic mice between PID 7 and 12. Increased ET was evident in microperfusates from fibrosarcoma tumor-implanted mice but not from melanoma tumor-implanted mice, which are not hyperalgesic. Intraplantar injection of ET-1 in naive and, to a greater extent, fibrosarcoma tumor-bearing mice produced spontaneous pain behaviors, suggesting that ET-1 activates primary afferent fibers. Intraplantar but not systemic injection of the ET-A receptor antagonist BQ-123 partially blocked tumor-associated mechanical hyperalgesia, indicating that ET-1 contributes to tumor-induced nociception. This model provides a unique approach for quantifying the behavioral, biochemical, and electrophysiological consequences of tumor-nerve interactions.
<i>Helicobacter pylori</i> infection in pigs is dominated by a Th1 and cytotoxic immune response (43.17) (2012)

Abstract H. pylori is the leading cause for peptic ulcer disease and gastric adenocarcinoma. While iTreg are required for long-term colonization without disease, Th1 and Th17 responses are associated with lower bacterial load at the expense of gastric pathology. We have developed computational models of H. pylori infection predicting a dominant Th1-response that results in lesion development in the gastric mucosa. In this study, pigs were infected with H. pylori strain SS1 or J99. Changes in PBMC populations were monitored over 2 months. Bacterial loads were assessed at 9 and 57 days post-infection. Both strains elicit a Th1 response with increased percentage of CD4+Tbet+ cells and elevated Tbet and IFN-γ mRNA in PBMC. A subset of CD8β+ cells expressing Tbet increased due to infection. These cells expressed low levels of CD8β, a property of cytotoxic T cells previously exposed to their cognate peptide. A significant increase of NK cells was observed in infected pigs pointing towards a predominant cytotoxic immune response. Strain J99 evoked a more dramatic acute response associated with bacterial clearance, while strain SS1 showed long-term colonization capacity. Ex vivo functional assays indicate strain-specific, weak and suppressed memory immune responses suggesting that specific virulence factors contribute to suppression of immune responses and chronic persistence. Data from this study will be used in the modeling process to refine computational models of H. pylori infection.
Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma (2014)

L1CAM promotes cell motility, invasion and metastasis formation in various human cancers and can be considered as a driver of tumor progression. Knowledge about genetic processes leading to the presence of L1CAM in cancers is of considerable importance. Experimentally, L1CAM expression can be achieved by various means. Over-expression of the transcription factor SLUG or treatment of cells with TGF-β1 can induce or augment L1CAM levels in cancer cells. Likewise, hypomethylation of the L1CAM promoter on the X chromosome correlates with L1CAM expression. However, presently no mechanisms that might control transcriptional activity are known. Here we have identified miR-34a as a suppressor of L1CAM. We observed that L1CAM positive endometrial carcinoma (EC) cell lines HEC1B and SPAC1L lost L1CAM protein and mRNA by treatment with demethylating agents or knock-down of the DNA-methyltransferase-1 (DNMT1). Concomitantly, several miRNAs were up-regulated. Using miRNA profiling, luciferase reporter assays and mutagenesis, we identified miR-34a as a putative binder to the L1CAM-3'UTR. Over-expression of miR-34a in HEC1B cells blocked L1CAM expression and inhibited cell migration. In ECC1 cells (wildtype p53) the activation of p53 caused miR-34a up-regulation and loss of L1CAM expression that was miR-34a dependent. We observed an inverse correlation between L1CAM and miR-34a levels in EC cell lines. In primary tumor sections areas expressing high amounts of L1CAM had less miR-34a expression than those with low L1CAM levels. Our data suggest that miR-34a can regulate L1CAM expression by targeting L1CAM mRNA for degradation. These findings shed new light on the complex regulation of L1CAM in human tumors.
Skill of donning surgical gloves amongst residents: a neglected skill (2019)

Background: Sepsis is a preventable cause of morbidity and mortality. Sepsis causes approximately 1 million new-born deaths annually. The global prevalence of maternal sepsis is 4.4% causing more than 5.7 million cases and one tenth of maternal deaths annually. Skin preparation, shaving and wound closure were some factors involved in surgical site infections. But the technique of wearing gloves in a sterile way has not received enough attention. Hence this cross sectional observational study was undertaken to assess the awareness and proficiency in this technique among the residents.Methods: 104 post graduate students from the departments of General Surgery, Obstetrics and Gynaecology, Paediatrics and Anaesthesiology from two medical colleges were administered a questionnaire and also were observed one at a time with a checklist in an OSCE station. Study was conducted in several sessions over a period of 2 months.Results: None of them were formally taught this technique. 36 (34.56%) were informally taught by seniors. 7 (6.72%) tore the glove while wearing. 39 (37.44%) put two fingers in one finger space. 42 (40.32%) touched bare skin with gloved hands while wearing. 54 (51.84%) touched bare skin with used surface of the glove while removing.Conclusions: Awareness about technique and skill of donning sterile gloves among residents of various specialities are not satisfactory. It is recommended to teach this skill as soon as the students enter medical school in a strict and formal way and monitor their proficiency throughout their training period.
Modeling of Gasoline Direct Injection Mixture Formation with KIVA-3V and Validation with Optical Engine Planar Laser Induced Fluorescence Measurements : Development of an Extended Coherent Flamelet Model(S.I. Engines, G.D.I. Modelling) (2004)

The computational code KIVA-3V has been used as the modeling platform for Gasoline Direct Injection engine simulations. Improved models for fuel injection, wall impingement and stratified combustion have been implemented. To complement the modeling effort, experimental data of an optical engine at the University of Michigan has provided extensive data for validating the new models. The experimental data include Planar Laser Induced Fluorescence measurements, with toluene as a tracer, of the injection, mixing and combustion events in an optical engine. In this work, focus is given on the combustion model development and validation with experiments.
Measurement Method of Soot Continuous Oxidation Rate on the DPF Coated With NOx Storage Reduction Catalyst (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Structures and Reactivities of Organocopper Compounds (2002)

Introduction Historical Perspective The Oxidation States of Copper Thermal Stability and Bonding in Organocopper(I) Compounds Homoleptic Organocopper Compounds CunRn Heteroleptic Organocopper Compounds Cun+mRnXm Organocuprates Neutral Homoleptic and Heteroleptic Organocuprates Anionic Homoleptic and Heteroleptic Organocuprates Lower- and Higher-order Cyanocuprates Concluding Remarks
Design of Skeletal Structures (2013)

In this chapter detailed design methods, with worked examples, are given for the design of beams, staircases, and columns subjected to gravity loads. It provides materials specifications. Precast structural frame design is an interactive procedure, and several iterations within the design routine are carried out. The result is that the subtleties of the process have been refined by the precasters to such a degree that it is difficult for the uninitiated to gain access to the thought process. Prefabrication of reinforced and prestressed concrete components has much greater potential for economy, structural performance and durability than cast-in situ concrete. The design of beams is based on ordinary reinforced or prestressed concrete principles for specified loads and support conditions. Staircase design is by reinforced or prestressed concrete solid slab or tee-beam analysis.
Phase-matched high-order-harmonic generation by guided intense femtosecond laser pulses (2003)

We present the experimental results of high-order harmonic generation by guided intense femtosecond Ti:sapphire pulses, using a rare-gas filled hollow fiber and a self-guided channel. Generation efficiency of the high-order harmonic was improved by phase-matched propagation in the guiding channel. More than 100-fold enhancement around the 25th harmonic (32 nm) was obtained with a 3-cm-long, Ar-filled hollow fiber. The harmonics around the 49th harmonic (16 nm) were also enhanced by two orders of magnitude compared to those in the plateau with a 7-mm-long, self-guided pulse in Ne. High-harmonic conversion efficiency of 10/sup -6/ was obtained by phase-matched propagation in Ne, producing > nJ harmonics in the cutoff region around the 49th harmonic. In both experiments, the harmonics near the cutoff region were preferentially enhanced. The results are well explained by considering both the intrinsic phase based on the single-atom response and the macroscopic phase matching in the high-intensity interaction region.
<i>Drosophila melanogaster</i> HI Histone Is Phosphorylated Stably (1987)

Phosphorylation of histone H1 is developmentally regulated in Drosophila spp. It cannot be detected in preblastoderm embryos or polytene salivary gland cells, but in cellular blastoderm, postblastoderm embryo, and amitotic adult head nuclei, it occurs with a frequency of roughly 4 x 10(5) molecules per nucleus. We used pulse-labeling to study the relationship between H1 synthesis and modification in cultured cells. These results reveal that the H1-associated phosphate is stable and suggest that Drosophila H1 is synthesized, translocated to the nucleus, associated with chromatin, and then phosphorylated. Partial tryptic digestion of Drosophila H1 revealed that the phosphorylation site is located within the globular, central domain of the protein. Thus, the developmentally regulated phosphorylation of Drosophila H1 presents two contrasts with previously studied H1 phosphorylation. It is not correlated with DNA replication, and it is located in the central domain of the protein.
Halovibrin, secreted from the light organ symbiont Vibrio fischeri, is a member of a new class of ADP-ribosyltransferases (1996)

The purification, cloning, and deduced amino acid sequence of an ADP-ribosyltransferase secreted from the marine bacterium Vibrio fischeri (V. fischeri ADP-r) is described. This enzyme was purified from culture supernatant, and partial amino acid sequence obtained from the purified protein was used to design a degenerate oligonucleotide probe that was used to clone a cross-hybridizing DNA fragment from V. fischeri genomic DNA. Recombinant Escherichia coli clones harboring this fragment possessed ADP-ribosyltransferase activity. The DNA fragment was sequenced, and deletion analysis localized the ADP-ribosyltransferase activity to one of the three possible open reading frames in the fragment; the deduced amino acid sequence from this open reading frame matched the amino acid sequence obtained from the purified protein. V. fischeri ADP-r has no significant homology (DNA or amino acid) with other known ADP-ribosyltransferases. This enzyme appears to require neither proteolytic cleavage nor a reducing agent for enzymatic activity. The cloned gene is expressed but not secreted in E. coli; however, it is secreted from a heterologous marine Vibrio species. We have named this enzyme halovibrin.