gebhart/patrepeval huggingface dataset:
Robust Emergency Communications Using TxID Watermark of ATSC DTV System (2009)

In today’s world, having a reliable communication system during emergency situations is of paramount importance to lessen the impact of the disasters. This paper proposes an emergency communication technique which is enabled by ATSC DTV transmitter identification (TxID) watermark signal. Theoretical and simulation results show that ATSC TxID watermark signal can reach a larger coverage area than the 8-VSB DTV signal and hence can be used to enable emergency communication during national disastrous situations. The coverage for this emergency communication system is predicted using popular Hata-Davidson propagation model and coverage maps clearly showing the extended and overlapped coverage for DTV stations in Huron and Stratford area in the province of Ontario, Canada is presented. Comparison with other existing emergency communication systems is carried out and performance matrices such as alerting message error rate, required no. of stations, network reliability etc. are evaluated to assess the robustness of the proposed emergency communication system.
Reshuffling of Aspergillus fumigatus Cell Wall Components Chitin and β-Glucan under the Influence of Caspofungin or Nikkomycin Z Alone or in Combination (2011)

Chitin and β-glucan are major cell wall components of Aspergillus spp. We investigated the antifungal activity of chitin synthesis inhibitors nikkomycin Z, polyoxin D, flufenoxuron, lufenuron, and teflubenzuron, alone and combined with the β-glucan synthesis inhibitor caspofungin. Only nikkomycin Z and caspofungin were found to act synergistically. The nikkomycin Z-induced chitin decrease corresponded with a β-glucan increase, while with the caspofungin-induced β-glucan decrease, an increase in chitin was found. This could explain the synergistic activity of this combination of drugs.
Two Novel DEG/ENaC Channel Subunits Expressed in Glia Are Needed for Nose-Touch Sensitivity in<i>Caenorhabditis elegans</i> (2013)

Neuronal DEG/ENaC (degenerin and epithelial Na(+) channel) Na(+) channels have been implicated in touch sensation. For example, MEC-4 is expressed in touch neurons in Caenorhabditis elegans and mediates gentle-touch response. Similarly, homologous mammalian ASIC2 and ASIC3 are expressed in sensory neurons and produce touch phenotypes when knocked out in mice. Here, we show that novel DEG/ENaC subunits DELM-1 and DELM-2 (degenerin-like channel mechanosensory linked-1 and degenerin-like channel mechanosensory linked-2) are expressed in glia associated with touch neurons in C. elegans and that their knock-out causes defects in mechanosensory behaviors related to nose touch and foraging, which are mediated by OLQ and IL1 sensory neurons. Cell-specific rescue supports that DELM-1 and DELM-2 are required cell-autonomously in glia to orchestrate mechanosensory behaviors. Electron microscopy reveals that in delm-1 knock-outs, OLQ and IL1 sensory neurons and associated glia are structurally normal. Furthermore, we show that knock-out of DELM-1 and DELM-2 does not disrupt the expression or cellular localization of TRPA-1, a TRP channel needed in OLQ and IL1 neurons for touch behaviors. Rather, rescue of the delm-1 nose-touch-insensitive phenotype by expression of a K(+) channel in socket glia and of a cationic channel in OLQ neurons suggests that DELM channels set basal neuronal excitability. Together, our data show that DELM-1 and DELM-2 are expressed in glia associated with touch neurons where they are not needed for neuronal structural integrity or cellular distribution of neuronal sensory channels, but rather for their function.
Quinuclidine Inhibitors of 2,3-Oxidosqualene Cyclase-Lanosterol Synthase:  Optimization from Lipid Profiles (1999)

Novel 3-substituted quinuclidine inhibitors of cholesterol biosynthesis are reported. Compounds were optimized against oxidosqualene cyclase-lanosterol synthase (OSC) inhibition in vivo, rather than by the conventional optimization of structure-activity relationship information based on in vitro OSC inhibition. Thus, examination of HPLC lipid profiles from orally dosed rats showed cholesterol biosynthetic intermediates and whether cholesterol levels were reduced. A new substituted quinuclidine pharmacophore 18a-c was rapidly found for the inhibition of OSC, and the most promising inhibitors were validated by the confirmation of potent OSC inhibition. Compound 16 gave an IC50 value of 83 +/- 11 nM for human and an IC50 value of 124 +/- 14 nM, for rat, coupled with oral and selective inhibition of cholesterol biosynthesis derived from OSC inhibition (rat, ED50 = 1.3 +/- 0.7 mg/kg, n = 5; marmoset, 15 mg/kg dose, n = 3, caused complete inhibition). These 3-substituted quinuclidines, which were derived from a quinuclidine series previously known to inhibit cholesterol biosynthesis at the squalene synthase step, may afford a novel series of hypocholesterolemic agents acting by the inhibition of OSC.
ISAR imaging method of radar target with short-term observation based on ESPRIT (2018)

A 2-D Inverse synthetic aperture radar (ISAR) imaging method is proposed, which only requires a short period of time for target observation. Typically, a long period of observing time is necessary to achieve high cross-range resolution in ISAR imaging since a wide observing angle is critical. However, long-term observation accompanies disadvantage in discriminating the target especially when the target has complicated motion. In this paper, we propose a 2-D ISAR imaging method with short-term observation. The down-range of scatterers is obtained by inverse fast Fourier transform (IFFT) and the cross-range of scatterers is obtained by estimation of signal parameters via rotational invariance technique (ESPRIT). To improve computational efficiency, we sort out the signal region and noise region with a certain threshold level and then the ESPRIT method is only applied to the signal region. A set of simulated and measured data of Boeing 727 as an aircraft target is used to validate the proposed imaging method in this paper. By adopting the proposed method, the required observation time of target can be reduced to 12.5%.
Protective Vaccine Efficacy of the Complete Form of PPE39 Protein from Mycobacterium tuberculosis Beijing/K Strain in Mice (2017)

The aim of this study was to evaluate the protective efficacy of MTBK_24820, a complete form of PPE39 protein derived from a predominant Beijing/K strain of <i>Mycobacterium tuberculosis</i> in South Korea. Mice were immunized with MTKB_24820, <i>M. bovis</i> Bacilli Calmette-Guérin (BCG), or adjuvant prior to a high-dosed Beijing/K strain aerosol infection. After 4 and 9 weeks, bacterial loads were determined and histopathologic and immunologic features in the lungs and spleens of the <i>M. tuberculosis</i>-infected mice were analyzed. Putative immunogenic T-cell epitopes were examined using synthetic overlapping peptides. Successful immunization of MTBK_24820 in mice was confirmed by increased IgG responses (<i>P</i> < 0.05) and recalled gamma interferon (IFN-γ), interleukin-2 (IL-2), IL-6, and IL-17 responses (<i>P</i> < 0.05 or <i>P</i> < 0.01) to MTBK_24820. After challenge with the Beijing/K strain, an approximately 0.5 to 1.0 log<sub>10</sub> reduction in CFU in lungs and fewer lung inflammation lesions were observed in MTBK_24820-immunized mice compared to those for control mice. Moreover, MTBK_24820 immunization elicited significantly higher numbers of CD4<sup>+</sup> T cells producing protective cytokines, such as IFN-γ and IL-17, in lungs and spleens (<i>P</i> < 0.01) and CD4<sup>+</sup> multifunctional T cells producing IFN-γ, tumor necrosis factor alpha (TNF-α), and/or IL-17 (<i>P</i> < 0.01) than in control mice, suggesting protection comparable to that of BCG against the hypervirulent Beijing/K strain. The dominant immunogenic T-cell epitopes that induced IFN-γ production were at the N terminus (amino acids 85 to 102 and 217 to 234). Its vaccine potential, along with protective immune responses <i>in vivo</i>, may be informative for vaccine development, particularly in regions where the <i>M. tuberculosis</i> Beijing/K-strain is frequently isolated from TB patients.
Serotonergic Stimulation of the Rat Hypothalamo‐Pituitary‐Adrenal Axis: Interaction between 5‐HT<sub>1A</sub> and 5‐HT<sub>2A</sub> Receptors (2004)

Acute stimulation of the hypothalamo-pituitary-adrenal (HPA) axis by selective serotonin reuptake inhibitors (SSRIs) is mediated by several postsynaptic 5-HT receptor subtypes. Activation of 5-HT(1A) and 5-HT(2A) receptors increases plasma corticosterone levels, and it is likely that these receptor subtypes are central to mediating the effects of SSRIs. To study the interaction of these receptors, rats were administered with the 5-HT(1A/7) agonist 8-OH-DPAT (0.05 to 1.25 mg/kg), the 5-HT(2A/C) agonist DOI (0.25 to 5 mg/kg), or a mixture of both compounds, and trunk blood was taken 60 min later. The two compounds given in combination produced a lower increase in corticosterone than DOI does alone. DOI and 8-OH-DPAT also produced a marked induction of c-Fos in the paraventricular nucleus (PVN), but the induction was not different if the two compounds were given together. These data show that the two serotonin receptor subtypes affect the HPA axis via a central target. In conclusion, 5-HT(1A) and 5-HT(2A) receptors regulate corticotrophin-releasing hormone (CRH) neurons via distinct but strongly interacting pathways, probably converging on the same neurons in the hypothalamus.
Compensation of DC link voltage variation of a multilevel series-connected H-bridge inverter (2010)

The phase voltages of a series-connected H-bridge multilevel inverter are formed from galvanically isolated secondaries of complicated transformer. The reactive energy of a reactive load flowing back to the DC links is not transferred to other phases the same way as is in two-level inverters. Therefore the DC link voltages in multilevel inverters fluctuate under load and cannot be considered constant. Voltage fluctuation causes several problems including erroneous voltage vector production and undesired harmonics to voltage and current. A simple compensation method for such a DC link voltage fluctuation in series-connected multilevel inverters is proposed. The method is shown to be applicable to both space vector modulation and duty-cycle modulation schemes. The algorithm also includes circulation of the modules to ensure equal loading of different DC links. The proposed method was simulated using the parameters of a 3 kV three-phase seven-level inverter. Laboratory measurements with a 100 kVA inverter also verify the operation. The simulations and test results show the algorithm to fix unideal voltages to correspond the demanded reference. Also DC link voltages remain very well in balance, because of the use of module circulation.
Charakterisierung von Patienten mit akutem Myokardinfarkt durch den Nachweis von mikrovaskulärer Obstruktion und „Late Enhancement“ im zeitlichen Verlauf von einem Jahr (2006)

Ziele: Die Bestimmung des Late Enhancement (LE) und der mikrovaskulären Obstruktion (MO) stellen in der frühen Infarktdiagnostik prognostische Parameter dar. Um eine langfristige Beurteilung der Prognose zu ermöglichen, haben wir Patienten nach Infarkt bis zu einem Jahr mit CMR kontrolliert Methode: 40 Patienten (Gruppe1, Alter: 56±13 Jahre) mit akutem erstem Myokardinfarkt mit erfolgreicher Rekanalisation wurden innerhalb der ersten 10 Tage einer MRT-Untersuchung des Herzens unterzogen. Es wurden weitere Kontrolluntersuchungen nach 6 und 12 Monaten durchgeführt. Bei 30 Patienten (Gruppe 2, Alter: 53±14 Jahre) mit akutem Myokardinfarkt wurden innerhalb der ersten 10 Tage zwei MRT-Untersuchungen durchgeführt, wobei die erste Untersuchung innerhalb von 48 Stunden erfolgte. Die MRT-Aufnahmen wurden bei 1,5 T unter Verwendung einer 6-Kanal-Spule durchgeführt. Es wurden T1-gewichtete Sequenzen in einer frühen (nach 2min, „early enhancement“, EE) und in einer späten (nach 10min, „late enhancement“, LE) Phase nach Kontrastmittelapplikation (Gd-DTPA, 0,2 mmol/kg KG) durchgeführt. Der linke Ventrikel wurde planimetrisch in Kurzachsenschnitten nach MO, EE und LE ausgewertet. Ergebnis: Im zeitlichen Verlauf von einem Jahr zeigte sich in Gruppe 1 eine Abnahme des LE von 17,2±11,9% in der Akutphase auf 11,91±9,4% nach 6 Monaten und auf 9,7±8,4% nach 12 Monaten. In der Akutphase konnte bei 28 Patienten (70%) No-Reflow-Zonen (MO) detektiert werden, nach 6 Monaten noch bei 12 Patienten (30%) und nach 12 Monaten zeigten noch 3 Patienten (8%) MO. In der kurzfristigen Kontrolle nach Myokardinfarkt in Gruppe 2 zeigte sich von der ersten zur zweiten Untersuchung eine Abnahme des LE von 20,6±12,2% auf 16,7±10,6% und eine Reduktion der MO von 3,6 auf 2,1%. Die mikrovaskuläre Obstruktion nimmt ebenfalls von der frühen Analyse 2min nach KM-Applikation (EE) bis zur Analyse 10min nach KM-Gabe (LE) ab Schlussfolgerung: Die wahre Größe der mikrovaskulären Obstruktion lässt sich nur durch sehr frühe MRT-Untersuchungen innerhalb der ersten 24–48 Stunden nach Myokardinfarkt nachweisen. Eine zeitliche frühe Darstellung nach KM-Applikation bildet die MO-Zone besser ab im Vergleich zu LE. Das Late enhancement nimmt im Verlauf über den Zeitraum von wenigen Tagen nach Infarkt ab, diese Abnahme ist bei einigen Patienten bis zu einem Jahr nach Infarkt feststellbar
Electron–hole doping asymmetry of Fermi surface reconstructed in a simple Mott insulator (2016)

It is widely recognized that the effect of doping into a Mott insulator is complicated and unpredictable, as can be seen by examining the Hall coefficient in high Tc cuprates. The doping effect, including the electron-hole doping asymmetry, may be more straightforward in doped organic Mott insulators owing to their simple electronic structures. Here we investigate the doping asymmetry of an organic Mott insulator by carrying out electric-double-layer transistor measurements and using cluster perturbation theory. The calculations predict that strongly anisotropic suppression of the spectral weight results in the Fermi arc state under hole doping, while a relatively uniform spectral weight results in the emergence of a non-interacting-like Fermi surface (FS) in the electron-doped state. In accordance with the calculations, the experimentally observed Hall coefficients and resistivity anisotropy correspond to the pocket formed by the Fermi arcs under hole doping and to the non-interacting FS under electron doping.
Performance evaluation of PI controlled series stacked power delivery architectures for high-efficiency data centers (2020)

Series-stacked architectures have been successfully deployed for data center applications at substantially higher efficiencies than conventional power delivery architectures. In the series-stacked architectures, servers are series-connected electrically to reduce the high step-down conversion stage of voltage utilized in the conventional architectures. Differential power processing converters are, therefore, used to regulate the servers’ voltages and compensate for the unpredicted mismatch between servers’ currents. The main contribution of this paper comprises novel control approaches based on PI controllers purposeful for the two architectures that have reported the highest reliability and efficiency in differential power processing namely: server-to-bus and server-to-virtual bus. Both systems employ a dual active bridge (DAB) converter to accommodate the fluctuating loads of each server. Unlike hysteresis current/voltage control commonly employed in the available literature, the proposed control approaches offer less complexity, lower harmonics, and higher immunity towards the noise, thus no need for high-quality sensors to successfully achieve voltage balance and/or optimal string current flow. Moreover, a comparative study has been structured between the investigated series-stacked architectures under the proposed PI control approaches showing the merits and the demerits of each architecture. The proposed controllers have been validated based on simulations and experimentally.
Optic nerve sheath diameter in normal-tension glaucoma patients (2011)

An increased ONSD is generally associated with increased intracranial pressure; however, ONSDs in a group of NTG patients also were significantly increased compared with controls. ON sheath compartmentation and thinning of the ON sheath are two possible explanations for an increase in the ONSD in patients with NTG.
Wearable computing for image-based indoor navigation of the visually impaired (2015)

In this paper, an image-based non-obtrusive indoor navigation system for the visually impaired is presented. The system makes use of image processing algorithms to extract floor regions from images captured from a wearable eye-mounted heads-up display device. A prototype system called VirtualEyes is presented, where floor regions are analyzed to provide the user with voiced guidance for navigation. The floor detection algorithm was tested against over 200 images captured from indoor corridors of various lighting conditions and achieved up to 81.8% accuracy.
Modelling the individual cell lag phase. Isolating single cells: protocol development (2003)

A tool is developed to isolate single cells to provide a suitable base for investigating and modelling the individual cell lag phase.
Prognostic value of microphthalmia-associated transcription factor as a marker for the detection of circulating melanoma cells in patients with melanoma (2009)

Microphthalmia-associated transcription factor (MITF) was investigated in this study as a marker for the detection of circulating melanoma cells by reverse transcription polymerase chain reaction (RT-PCR).The aim of the study was to determine the prognostic value of MITF in patients with melanoma. Peripheral blood samples from 201 melanoma patients in all stages of the disease were analyzed by RT-PCR for the expression of MITF. A blood sample for analysis was obtained from each patient at the time of inclusion in the study. MITF mRNA was detected in blood samples from 32 (15.9%) out of 201 melanoma patients. Median follow-up for patients was 53 months (range 3-84 months). Both progression-free survival (p=0.005, log-rank test) and overall survival (p=0.042, log-rank test) were significantly shorter in patients positive for MITF in comparison to patients negative for MITF. In a multivariate regression analysis the value of MITF was an independent prognostic factor for progression-free survival (hazard ratio=2.54 ; 95% CI, 1.06-6.13 ; p=0.038) together with AJCC stage of the disease, while the AJCC stage of the disease was the only independent prognostic factor for overall survival. Our results suggest that analysis MITF as a marker for the detection of circulating melanoma cells has a prognostic value in patients with melanoma.
Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors. (2001)

The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. The findings have implications for the development of effective neuroprotective and restorative therapeutic interventions for Parkinson’s disease.
THE SELECTIVE ANTICANCER AGENT PB-100 INHIBITS INTERLEUKIN-6 INDUCED ENHANCEMENT OF GLIOBLASTOMA CELL-PROLIFERATION IN-VITRO (1994)

The multifunctional cytokine interleukin-6 behaves as a growth factor for various malignancies. It is produced in significant amounts by glioblastoma cells. When exogenous IL-6 is added (pg/ml) to culture medium of human glioblastoma cells and normal (non malignant) astrocytes used as controls, it exerts a dose dependent and differential effect on these two cell lines. Enhancement of cell proliferation is twice as high for glioblastoma cells as for astrocytes. In vitro, the novel anticancer agent PB-100 (mu g/ml) dose dependently inhibits this stimulatory activity. In addition, increasing PB-100 concentrations finally induce death of the malignant cells, yet do not impede multiplication of normal astrocytes. PB-100 does not abolish IL-6 production by cells, but keeps its level down to physiological values. PB-100 should therefore find its place in therapies requiring control of IL-6 production.
Facile Synthesis of (2<i>S</i>,3<i>R</i>)-3-Amino-2-Hydroxycarboxylic Acids, the Key Components of Amastatin and Bestatin (1992)

Abstract The title amino acids, (2S,3R)-3-amino-2-hydroxy-5-methyl-hexanoic acid (AHMHA) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), are stereoselectively prepared from (4R,5R)-5-allyl-4-methoxy-2-oxazolidinone which is readily accessible from the previously reported chiral synthon, (4R,5R)-5-phenylseleno-4-methoxy-2-oxazolidinone.
Direct determination of the intermolecular interaction contribution to the refractive index of carbon dioxide and sulfur hexafluoride (1979)

The experimental values of the first and the second refractivity virial coefficients have been determined for carbon dioxide and sulfur hexafluoride. In the case of carbon dioxide the experimental second refractivity virial coefficient is less than the classically calculated theoretical value and for sulfur hexafluoride the experimental value is larger than the theoretical value. Combined with the earlier values of the second dielectric virial coefficient, the present experimental results agree well with the integrated collision induced absorption in the infrared and the far infrared.
LASING IN SUB-MICRON WIDE VERTICAL CAVITY MICROLASERS (1991)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. SCHERER, J. L. JEWELL, and J. P. HARBISON, "LASING IN SUB-MICRON WIDE VERTICAL CAVITY MICROLASERS," Optics & Photonics News 2(12), 9-9 (1991) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Chaotic Synchronization on Optical Phases in Bandwidth- Broadened Semiconductor Lasers Subject to Optical Injection (2003)

Chaotic optical communication at high bit rates has attracted great attention because of its potential application in high‐speed optical spread spectrum communications. Among several proposed setups, all‐optical systems, such as the optical injection system and the optical feedback system, can achieve chaotic synchronization on the amplitude, the slowly‐varying phase of the chaotic envelope, and the fast‐varying phase of the optical field. However, all of the experimental work reported so far demonstrated only the synchronization of the intensity waveform or, equivalently, the amplitude waveform of the laser field. This report experimentally demonstrates chaotic synchronization on the fast‐varying and the slowly‐varying optical phases of the bandwidth‐broadened semiconductor lasers subject to the optical injection. The result shows a good synchronization quality.