gebhart/patrepeval huggingface dataset:
Experimental Studies of the Pathogenesis of Infections Due to Pseudomonas aeruginosa: Effect of Treatment with Protease Inhibitors (1983)

Data are presented showing that treatment of burned, Pseudomonas aeruginosa-infected mice with the protease inhibitor alpha 2-macroglobulin but not treatment with phosphoramidon enhanced survival. Treatment with alpha 2-macroglobulin caused reductions in bacterial counts in the skin and livers of infected mice and also protected liver elongation factor 2. Similar results were observed when human IgG was used for treatment. The protective effect of the IgG treatment was probably due to the presence of opsonizing antibodies in the preparation. The protective capacity of the IgG could be removed by its adsorption with heat-killed cells of the strain used for infecting the mice. The protection afforded by alpha 2-macroglobulin was not due to the presence of opsonizing antibodies in the preparation used. It appeared to be due to inhibition of the proteolytic, not the elastolytic, activities of alkaline protease and elastase elaborated by the organisms growing in the burned skin tissue. Proteolytic activities of these enzymes appeared to serve as virulence factors in P. aeruginosa by decreasing the generation time in vivo of the microorganisms growing in the burned skin tissue and by allowing the organisms to spread from this local site into the systemic circulation. Treatment of pseudomonas infections of burn wounds with protease inhibitors may serve as an alternative to antibiotic treatment and/or immunotherapy.
Sensitivity Analysis in Diagnostic Modelling: Monte Carlo Filtering and Regionalised Sensitivity Analysis, Bayesian Uncertainty Estimation and Global Sensitivity Analysis (2002)

This chapter contains sections titled: Model Calibration and Factors Mapping Setting Monte Carlo Filtering and Regionalised Sensitivity Analysis Putting MC Filtering and RSA to Work: The Problem of Hedging a Financial Portfolio Putting MC Filtering and RSA to Work: The Level E Test Case Bayesian Uncertainty Estimation and Global Sensitivity Analysis Putting Bayesian Analysis and Global SA to Work: Two Spheres Putting Bayesian Analysis and Global SA to Work: A Chemical Experiment Caveats
How Do Li Atoms Pass through the Al<sub>2</sub>O<sub>3</sub> Coating Layer during Lithiation in Li-ion Batteries? (2013)

We studied the lithiation of Al2O3 and found the energetically most favorable composition of Li3.4Al2O3 using ab initio molecular dynamics simulations. The calculated Li/Al ratio and corresponding volume expansion ratio agree well with reported experimental observations. The Al atoms accept electrons from the incoming Li atoms during lithiation, leading to the formation of various Al structures, that is, isolated atoms, dimers, trimers, and ring- and chain-type clusters. The Li atoms in the optimal concentration diffuse faster by four (five) orders of magnitude than the Al (O) atoms, and they also diffuse faster by four orders of magnitude than the Li atoms in a dilute Li concentration. We suggest that in Li-ion batteries the lithiation of the Al2O3 coating layer proceeds until a thermodynamically stable phase is reached; then, extra Li atoms overflow into the electrode by passing through the coating layer.
Brain aminoacyl arylamidase. Further purification of the soluble bovine enzyme and studies on substrate specificity and possible active-site residues (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBrain aminoacyl arylamidase. Further purification of the soluble bovine enzyme and studies on substrate specificity and possible active-site residuesJ. B. Suszkiw and Arthur S. BrecherCite this: Biochemistry 1970, 9, 20, 4008–4017Publication Date (Print):September 29, 1970Publication History Published online1 May 2002Published inissue 29 September 1970https://pubs.acs.org/doi/10.1021/bi00822a021https://doi.org/10.1021/bi00822a021research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Appendix E: Quality Assurance (1992)

Appendix E: Quality Assurance D. R. White, D. R. White Chairman Search for other works by this author on: Oxford Academic Google Scholar J. C. Buckland-Wright, J. C. Buckland-Wright Search for other works by this author on: Oxford Academic Google Scholar R. V. Griffith, R. V. Griffith Search for other works by this author on: Oxford Academic Google Scholar L. N. Rothenberg, L. N. Rothenberg Search for other works by this author on: Oxford Academic Google Scholar C. K. Showwalter, C. K. Showwalter Search for other works by this author on: Oxford Academic Google Scholar G. Williams, G. Williams Search for other works by this author on: Oxford Academic Google Scholar I. J. Wilson, I. J. Wilson Search for other works by this author on: Oxford Academic Google Scholar M. Zankl M. Zankl Search for other works by this author on: Oxford Academic Google Scholar Journal of the International Commission on Radiation Units and Measurements, Volume os25, Issue 1, 15 June 1992, Page 165, https://doi.org/10.1093/jicru/os25.1.165 Published: 27 April 2016
Cooperative device-to-device communications in cellular networks (2015)

To meet the increasing demand of wireless broadband applications in 4G/beyond 4G cellular networks, D2D communication can serve as a candidate paradigm to improve spectrum efficiency. By reusing the spectrum of cellular users, two D2D users can form a direct data link without routing base stations and core networks; thus, the spectral efficiency can be improved. Further, when the cooperation between cellular users and D2D users is enabled, a win-win situation can be achieved to make all users better off. Thus motivated, we propose a cooperative D2D communication framework in this article, which introduces the cooperative relay technique to conventional underlay/overlay D2D communications. Adaptive mode selection and spectrum allocation schemes are also presented to ensure better performance for both cellular and D2D users. Extensive numerical results show the effectiveness of the proposed framework for a variety of scenarios.
Cationic Cobalt(III)‐Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives (2015)

A cationic cobalt(III)-catalyzed direct C-H amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant-free conditions with a broad substrate scope. Moreover, 6-arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, and anti-HCV activities, can be smoothly amidated, thus offering a mild protocol for their late stage functionalization.
Diagnostic ultrasound : physics and equipment (2010)

All healthcare professionals practising ultrasound in a clinical setting should receive accredited training in the principles and practice of ultrasound scanning. This second edition of Diagnostic Ultrasound: Physics and Equipment provides a comprehensive introduction to the physics, technology and safety of ultrasound equipment, with high quality ultrasound images and diagrams throughout. It covers all aspects of the field at a level intended to meet the requirements of UK sonography courses. New to this edition: • Updated descriptions of ultrasound technology, quality assurance and safety. • Additional chapters dedicated to 3D ultrasound, contrast agents and elastography. • New glossary containing definitions of over 500 terms. The editors and contributing authors are all authorities in their areas, with contributions to the scientific and professional development of ultrasound at national and international level
A fast algorithm for bottom-up document layout analysis (1997)

This paper describes a new bottom-up method for document layout analysis. The algorithm was implemented in the CLIDE (Chemical Literature Data Extraction) system, but the method described here is suitable for a broader range of documents. It is based on Kruskal's algorithm and uses a special distance-metric between the components to construct the physical page structure. The method has all the major advantages of bottom-up systems: independence from different text spacing and independence from different block alignments. The algorithms computational complexity is reduced to linear by using heuristics and path-compression.
[Treatment of hyperthyroidism from Graves-Basedow's disease]. (1993)

The Graves's Disease is the most frequent cause of hyperthyroidism. Currently, there is a lack of consensus with respect to the therapeutical role played by synthetic antithyroids, radioactive iodine and surgery. In order to study in depth this issue, we have analyzed the results of the therapy administered to 217 patients with Graves's Disease: 96 were treated with synthetical anti-thyroids, 46 with surgery and 75 with radioactive iodine. After twelve months of therapy with synthetic antithyroids, remission of the disease was observed in 64 patients (67%); the only factor predicting such remission was the absence of ophthalmopathy (p < 0.05); all 64 patients were followed-up during 12 months, detecting the recurrence of hyperthyroidism in 33 of them. Such recurrence is predicted by the serum levels of thyroid hormones before the administration of the therapy (p < 0.001). On the contrary, in patients treated with surgery or radioactive iodine, hyperthyroidism was controlled in 91% and 100% of them, respectively. Given the evolution of patients with Graves's Disease treated with synthetic antithyroids, we suggest the use of a more aggressive approach for the management of these patients.
Synthesis of C-glycosyl thiazoles (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of C-glycosyl thiazolesMercedes Fuertes, Maria T. Garcia-Lopez, Guillermo Garcia-Munoz, and Manfred StudCite this: J. Org. Chem. 1976, 41, 26, 4074–4077Publication Date (Print):December 1, 1976Publication History Published online1 May 2002Published inissue 1 December 1976https://pubs.acs.org/doi/10.1021/jo00888a005https://doi.org/10.1021/jo00888a005research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Motion Image Detection Method Based on the Inter-Frame Difference Method (2014)

Mobile robot vision system based on image information on environment, to make it automatic separation from obstacles and achieve precise mathematical description of obstacles, we construct detection model which combined by the frame difference method and background subtraction for target detection, comprehensive utilization of the main idea of three frame difference image method, the background subtraction and frame difference method combined to complement each other, thereby overcoming each other's weaknesses and improving the effect of target detection, experiment results show that this method can effectively improve the efficiency of target detection.
Inhibition of Neointimal Proliferation After Coronary Angioplasty by Low-Molecular-Weight Heparin (Clivarine) and Polyethyleneglycol-Hirudin (1996)

Proliferation of medial smooth muscle cells (SMC) plays a major role in restenosis after coronary angioplasty and can be inhibited by heparin. Platelets stimulate SMC proliferation, and their aggregation after angioplasty can be reduced by the direct thrombin inhibitor hirudin. In a porcine coronary stent-angioplasty model (16 animals, 4 per group), we studied the effect of 3- and 14-day treatment with a novel long-lasting polyethyleneglycol-conjugated (PEG-hirudin, LU 57291), at a dose of 1 mg/kg intravenously (i.v.) and then subcutaneously once daily as compared with chronic low-molecular-weight heparin (LMWH) clivarine at a dose of 150 IU/kg as an intravenous bolus, followed by 10 IU/kg/h i.v. for 24 h, followed by 75 IU/kg twice daily, as compared with acute unfractionated heparin (100 IU/kg) as a control. Sixteen animals were randomly assigned to the four treatment groups. Four weeks after angioplasty, hearts were perfusion-fixed and six slices per angioplasty segment were analyzed for neointimal thickness and neointimal area (% of total vessel cross-sectional area). Maximal neointimal thickness was 1.10 +/- 0.2 mm in the control group (mean +/- SD, n = 9 arteries) and was significantly lower in both PEG-hirudin (0.62 +/- 0.22 and 0.86 +/- 0.18 mm, 11 and 10 arteries) and in clivarine-treated animals (0.75 +/- 0.33 mm, 11 arteries, p < 0.01). Similarly, neointimal area was smaller in PEG-hirudin groups (20 +/- 12 and 21 +/- 12%) and in the clivarine group (24.8 +/- 13.2%) as compared with the control group (41 +/- 17%, p < 0.02). We conclude that PEG-hirudin and clivarine reduce neointimal proliferation in a coronary stent-angioplasty model. Prolonged PEG-hirudin has no better effect than therapy limited to 3 days.
Recognition of Income - the Choice between the Earnings or Cash Basis (1992)

This article attempts to introduce and examine generally the taxpayer's choice between the two basic ways of income recognition for the purposes of tax accounting (the preparation of accounts for tax purposes). In Singapore taxpayers are assessed on an earnings basis and the Revenue does not recognise computation of income on a cash basis. However, there are no cases touching on this point. This article will examine whether there is a place for computation of income on a cash basis in some businesses.
PCR-Based Methods for Mutation Detection (2006)

Although many, even most, methods of mutation detection depend on polymerase chain reaction (PCR), in the majority of techniques PCR itself does not detect the actual mutation. Rather, PCR generates an amplicon that is then analyzed by some other method to find possible mutations within the ampli-con, such as conformation-based techniques like single-stranded conformational polymorphism (SSCP) analysis, denaturing gradient gel electrophoresis (DGGE), or sequencing. However, there are some methods in which a modified PCR acts as the primary mutation-detection system, although some type of electrophoresis might be needed to separate the subsequent amplicons. These include real-time PCR, the amplification refractory mutation system (ARMS), quantitative fluorescent PCR (QF-PCR), or a derivative of the oligoligation assay, multiplex ligation-dependent probe amplification (MLPA). Also discussed is the single-nucleotide primer extension assay and a proprietary derivative of it called Pronto™. Because it uses a DNA polymerase in a post-PCR extension step, it can be deemed to fall into the group of PCR-based methods of mutation detection. A primary limitation of these methods is that, with a few exceptions, they are only suitable for testing for mutations that have been previously detected and characterized by other techniques.
Chemistry of enol silyl ethers. 5. A novel cycloaromatization reaction. Regiocontrolled synthesis of substituted methyl salicylates (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of enol silyl ethers. 5. A novel cycloaromatization reaction. Regiocontrolled synthesis of substituted methyl salicylatesTak-Hang Chan and Peter BrownbridgeCite this: J. Am. Chem. Soc. 1980, 102, 10, 3534–3538Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/ja00530a038https://doi.org/10.1021/ja00530a038research-articleACS PublicationsRequest reuse permissionsArticle Views1753Altmetric-Citations188LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Implementation of artificial neural networks to automate spectral-analysis-of-surface-waves method (2005)

Women with AAAs are being treated at older ages and smaller AAA diameters and are undergoing rupture repair at smaller diameters than men. Women are more likely to experience perioperative complications as a result of less favorable vascular anatomy. Age >80 years, comorbidity, presentation, and type of repair are more important predictors of mortality than gender.
Some Preliminary Observations on the Catalytic Fading of Dye Mixtures (1973)

The ‘catalytic fading’ of C.I. Acid Violet 4 in the presence of C.I. Acid Yellow 112 has been investigated in solution, on films and on fibres. Trace amounts of an impurity have been isolated from C.I. Acid Yellow 112. This impurity has been shown to fade C.I. Acid Violet 4 catalytically. Examination of the impurity and comparison of its properties with those of the sodio derivative of ethyl acetoacetate suggest that it is a β‐ketonic acid derivative present in part as an enolic sodium salt.
Adaptive autonomous management of ad hoc networks (2003)

Ad hoc networks are fundamentally different from wireline networks due to the following peculiarities. Ad hoc networks are autonomously formed with a large number of heterogeneous nodes (ranging in complexity from sensors to palmtops and fully functional laptops and routers) without the aid of any pre-existing communication infrastructure. Therefore, tasks are distributed over and carried out by groups of collaborating nodes. In addition, the nodes run on battery. They will have to be power-conscious to conserve energy, and the functions offered by a node will depend on its available power level and capability. Furthermore, their topology can be highly dynamic due to autonomous mobility of nodes and physical characteristics of wireless links. Energy constraints, varying wireless communication bandwidth and quality, and node mobility result in networks becoming partitioned more frequently. These make managing ad hoc networks significantly more challenging than managing wireline networks. We propose the Guerrilla Management Architecture to satisfy the survivability, adaptability, autonomy, economy, heterogeneity, and scalability requirements in managing ad hoc networks. Success in addressing these research issues will lead to robust deployment of ad hoc networks and their effective network operations and efficient resource utilization. The Guerrilla management architecture builds on the following model and mechanisms to address these specific management requirements.
Neural network and DSP based decoderfor DTMF signals (2000)

A novel approach for the efficient digital decoding of DTMF signals used in telecommunications is based on an artificial neural network (ANN) implemented on a digital signal processor (DSP). After the appropriate training phase the ANN is able to associate a digital output corresponding to the received DTMF signal. The proposed approach may allow the possibility of implementing a real-time non-intrusive decoder. This decoder is fully described and particular attention paid to the solutions adopted for optimising the ANN's computation on the DSP. A comparison is made of the performance obtained by the proposed approach, and that recommended by the CCITT standard. Finally, experimental results are given which highlight the performance of the apparatus in different real conditions in DTMF signal decoding.
Insertion of the amyloid precursor protein into lipid monolayers: effects of cholesterol and apolipoprotein E (2004)

APP (amyloid precursor protein), together with Chol (cholesterol) and ApoE (apolipoprotein E), has been linked to Alzheimer's disease. We have examined the hypothesis that interaction of APP with the lipid membranes is modulated by Chol and ApoE. Insertion of APP into lipid monolayers was first evidenced as an increase in the surface pressure. APP injected into a subphase induced a substantial increase in the surface pressure of monolayers prepared from PC (L-alpha-phosphatidylcholine), Chol, SPM (sphingomyelin) and PS (L-alpha-phosphatidylserine), the major lipids present in the plasma membranes of brain cells. At a given initial pressure, the insertion of APP into expanded monolayers is higher than that in condensed monolayers, in the order Chol>PC>SPM>PS. The membrane insertion capacity of APP was also measured from surface pressure versus area (pi-A) isotherms of APP-lipid monolayers. The increase in the mean area per molecule in protein-lipid monolayers, in the order PC>Chol>PS>SPM, provides further evidence for protein-lipid interactions. These interactions occurred at optimum salt levels and optimum pH values close to physiological conditions (150 mM NaCl and pH 7.4). In addition, ApoE4 affected the insertion of APP into lipid films. APP-ApoE complexes showed a decreased ability to penetrate lipid monolayers at a constant area. APP-ApoE complexes expanded the pi-A isotherm of a Chol monolayer to a lesser extent than APP alone. These experiments demonstrate the roles of Chol and ApoE in the modulation of membrane insertion of APP.