gebhart/patrepeval huggingface dataset:
Lack of an Endogenous Anti-inflammatory Protein in Mice Enhances Colonization of B16F10 Melanoma Cells in the Lungs (2010)

Emerging evidence indicates a link between inflammation and cancer metastasis, but the molecular mechanism(s) remains unclear. Uteroglobin (UG), a potent anti-inflammatory protein, is constitutively expressed in the lungs of virtually all mammals. UG-knock-out (UG-KO) mice, which are susceptible to pulmonary inflammation, and B16F10 melanoma cells, which preferentially metastasize to the lungs, provide the components of a model system to determine how inflammation and metastasis are linked. We report here that B16F10 cells, injected into the tail vein of UG-KO mice, form markedly elevated numbers of tumor colonies in the lungs compared with their wild type littermates. Remarkably, UG-KO mouse lungs overexpress two calcium-binding proteins, S100A8 and S100A9, whereas B16F10 cells express the receptor for advanced glycation end products (RAGE), which is a known receptor for these proteins. Moreover, S100A8 and S100A9 are potent chemoattractants for RAGE-expressing B16F10 cells, and pretreatment of these cells with a blocking antibody to RAGE suppressed migration and invasion. Interestingly, in UG-KO mice S100A8/S100A9 concentrations in blood are lowest in tail vein and highest in the lungs, which most likely guide B16F10 cells to migrate to the lungs. Further, B16F10 cells treated with S100A8 or S100A9 overexpress matrix metalloproteinases, which are known to promote tumor invasion. Most notably, the metastasized B16F10 cells in UG-KO mouse lungs express MMP-2, MMP-9, and MMP-14 as well as furin, a pro-protein convertase that activates MMPs. Taken together, our results suggest that a lack of an anti-inflammatory protein leads to increased pulmonary colonization of melanoma cells and identify RAGE as a potential anti-metastatic drug target.
Treatment of malignant migrating partial epilepsy of infancy with rufinamide: report of five cases (2011)

The syndrome of malignant migrating partial seizures of infancy (MMPEI) is characterized by early onset of multiple seizures types, highly pharmaco-resistant seizures, and overall poor prognosis. In this study, we investigated retrospectively the efficacy of rufinamide (RUF) in five infants with MMPEI, by examining seizure type and frequency, EEG features and antiepileptic drug use. The data demonstrate that two of the five patients showed good efficacy and tolerability for RUF with a > 50% reduction in seizure frequency. The use of RUF for the treatment of MMPEI may therefore provide some hope for such infants and should be further validated. [Published with video sequences].
NEW HIGH-POWER STABLE MODES OF OPERATION OF THE ARGON LASER (1968)

We report several new high-power stable modes of operation of the argon laser. These types of operation are characteristic of the laser itself; no mode-selecting techniques are used. We have observed output powers of 2 W with up to 90% of the power in a single optical frequency, as well as several other new stable output spectra.
Synthesis and reactivity of small phosphorus-containing dendritic wedges (dendrons) (2002)

The synthesis of two small dendrons (dendritic wedges) is reported and the reactivity of the functionality located at the core is studied. The first dendron has no reactive functionality on the surface, but possesses a vinyl group activated by a P=N-P=S linkage at the core; this vinyl group reacts slowly but cleanly with 2,3-dimethylbutadiene in Diels-Alder additions. The second dendron has aldehyde groups on the surface and one protected phenol group at the core. The deprotection occurs in very mild conditions, leading to a dendron having one phenol and four aldehyde groups. The reactivity of the phenol is demonstrated by the addition of a diisocyanate, affording a carbamate function and the grafting of an isocyanate group at the core of the dendron.
Effect of sarcoptic mange mite infestation on the growth and immunity in growing-finishing pigs (1983)

Twenty -eight pigs were used to evaluate the effect the sarcoptic mange mite infestation on growth and immunity of growing-finishing pigs. Although mange mite infestation did not affect gain, the white blood cell counts were increased (23.6 vs. 28.6) two weeks after the infestation, corresponding to the mite generation. Two weeks after the infestation lymphocytes were decreased (61.0 vs. 51. 3%) and neutrophils were increased (25.7 vs. 35.1%). It appears from these data that sarcoptic mange mite infestation may influence immune status of growing-finishing pigs.; Swine Day, Manhattan, KS, November 10, 1983
Digital Privacy (2007)

THE PRIVACY SPACE Privacy Enhancing Technologies for the Internet III: Ten Years Later, I. Goldberg Communication Privacy, A. Pfitzmann, A. Juschka, A.-K. Stange, S. Steinbrecher, and S. Kopsell, and Privacy-Preserving Cryptographic Protocols, M.J. Atallah and K.B. Frikken PRIVACY ATTACKS Byzantine Attacks on Anonymity Systems, N. Borisov, G. Danezis, and P. Tabriz Introducing Traffic Analysis, G. Danezis and R. Clayton Privacy, Profiling, Targeted Marketing, and Data Mining, J. Vaidya and V. Atluri PRIVACY ENHANCING TECHNOLOGIES Enterprise Privacy Policies and Languages, M. Backes and M. Durmuth Uncircumventable Enforcement of Privacy Policies via Cryptographic Obfuscation, A. Narayanan and V. Shmatikov Privacy Protection with Uncertainty and Indistinguishability, X.S. Wang and S. Jajodia Privacy-Preserving Techniques in Data Mining, C. Su, J. Zhou, F. Bao, G. Wang, and K. Sakurai USER PRIVACY HCI Designs for Privacy-Enhancing Identity Management, S. Fischer-Hubner, J. Soren Pettersson, M. Bergmann, M. Hansen, S. Pearson, and M. Casassa Mont Privacy Perceptions among Members of Online Communities, M. Karyda and S. Kokolakis Perceived Control: Scales for Privacy in Ubiquitous Computing, S. Spiekermann PRIVACY UBIQUITOUS COMPUTING RFID: Technological Issues and Privacy Concerns, P. Najera and J. Lopez Privacy of Location Information, C.A. Ardagna, M. Cremonini, E. Damiani, S. De Capitani di Vimercati, and P. Samarati Beyond Consent: Privacy in Ubiquitous Computing (Ubicomp), J. Camp and K. Connelly THE ECONOMICS OF PRIVACY A Risk Model for Privacy Insurance, A.N. Yannacopoulos, S. Katsikas, S. Gritzalis, C. Lambrinoudakis, and S.Z. Xanthopoulos What Can Behavioral Economics Teach Us About Privacy? A. Acquisti and J. Grossklags PRIVACY AND POLICY Privacy of Outsourced Data, S. De Capitani di Vimercati, S. Foresti, S. Paraboschi, and P. Samarati Communications Data Retention: A Pandora's Box for Rights and Liberties? L. Mitrou Surveillance of Emergent Associations: Freedom of Association in a Network Society, K.J. Strandburg
β cell expression of IGF-I leads to recovery from type 1 diabetes (2002)

Patients with type 1 diabetes are identified after the onset of the disease, when β cell destruction is almost complete. β cell regeneration from islet cell precursors might reverse this disease, but factors that can induce β cell neogenesis and replication and prevent a new round of autoimmune destruction remain to be identified. Here we show that expression of IGF-I in β cells of transgenic mice (in both C57BL/6–SJL and CD-1 genetic backgrounds) counteracts cytotoxicity and insulitis after treatment with multiple low doses of streptozotocin (STZ). STZ-treated nontransgenic mice developed high hyperglycemia and hypoinsulinemia, lost body weight, and died. In contrast, STZ-treated C57BL/6–SJL transgenic mice showed mild hyperglycemia for about 1 month, after which they normalized glycemia and survived. After STZ treatment, all CD-1 mice developed high hyperglycemia, hypoinsulinemia, polydipsia, and polyphagia. However, STZ-treated CD-1 transgenic mice gradually normalized all metabolic parameters and survived. β cell mass increased in parallel as a result of neogenesis and β cell replication. Thus, our results indicate that local expression of IGF-I in β cells regenerates pancreatic islets and counteracts type 1 diabetes, suggesting that IGF-I gene transfer to the pancreas might be a suitable therapy for this disease.
An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease (2018)

Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer's disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well understood. As a result, it has proved difficult to identify optimal agents that target disease-relevant forms of Aβ. Here, we combined the use of Aβ-rich aqueous extracts of brain samples from AD patients as a source of human Aβ and live-cell imaging of iPSC-derived human neurons to develop a bioassay capable of quantifying the relative protective effects of multiple anti-Aβ antibodies. We report the characterization of 1C22, an aggregate-preferring murine anti-Aβ antibody, which better protects against forms of Aβ oligomers that are toxic to neurites than do the murine precursors of the clinical immunotherapeutics, bapineuzumab and solanezumab. These results suggest further examination of 1C22 is warranted, and that this bioassay maybe useful as a primary screen to identify yet more potent anti-Aβ therapeutics.
Two- and Three-Dimensional Models for Risk Assessment of Radiation-Enhanced Colorectal Tumorigenesis (2008)

Astronauts may be at an increased risk for developing colorectal cancer after a prolonged interplanetary mission given the potential for greater carcinogenic effects of radiation to the colon. In addition, with an increase in age, there is a greater incidence of premalignant colon adenomas with age. In the present study, we have compared the effects of radiation on human colon epithelial cells in two-dimensional (2D) monolayer culture, in three-dimensional (3D) culture, and in intact human colon tissue biopsies. Immortalized colon epithelial cells were irradiated at the NASA Space Radiation Laboratory (NSRL) with either 1 Gy 1 GeV/nucleon (56)Fe particles or 1 Gy 1 GeV/nucleon protons and were stained at various times to assess DNA damage and repair responses. The results show more persisting damage at 24 h with iron-particle radiation compared to protons. Similar results were seen in 3D colon epithelial cell cultures in which (56)Fe-particle-irradiated specimens show more persisting damage at 24 h than those irradiated with low-LET gamma rays. We compared these results to those obtained from human colon tissue biopsies irradiated with 1 Gy gamma rays or 1 Gy 1 GeV (56)Fe particles. Observations of radiation-induced DNA damage and repair in gamma-irradiated specimens revealed more pronounced early DNA damage responses in the epithelial cell compartment compared to the stromal cell compartment. After low-LET irradiation, the damage foci mostly disappeared at 24 h. Antibodies to more than one type of DNA repair factor display this pattern of DNA damage, and staining of nonirradiated cells with nonphosphorylated DNA-PKcs shows a predominance of epithelial staining over stromal cells. Biopsy specimens irradiated with high-LET radiations also show a pattern of predominance of the DNA damage response in the highly proliferative epithelial cell compartment. Persistent unrepaired DNA damage in colon epithelial cells and the differing repair responses between the epithelial and mesenchymal compartments in tissues may enhance tumorigenesis by both stem cell transformation and alterations in the radiation-induced permissive tissue microenvironment that may potentiate cancer progression.
Integration Site Choice of a Feline Immunodeficiency Virus Vector (2006)

We mapped 226 unique integration sites in human hepatoma cells following gene transfer with a feline immunodeficiency virus (FIV)-based lentivirus vector. FIV integrated across the entire length of the transcriptional units. Microarray data indicated that FIV integration favored actively transcribed genes. Approximately 21% of FIV integrations within transcriptional units occurred in genes regulated by the LEDGF/p75 transcriptional coactivator. DNA in regions of FIV insertion sites exhibited a "bendable" structure and a pattern of duplex destabilization favoring strand separation. FIV integration preferences are more similar to those of primate lentiviruses and distinct from those of Moloney murine leukemia virus, avian sarcoma leukosis virus, and foamy virus.
Dictionary learning based object detection and counting in traffic scenes (2010)

The objective of object recognition algorithms in computer vision is to quantify the presence or absence of a certain class of objects, for e.g.: bicycles, cars, people, etc. which is highly useful in traffic estimation applications. Sparse signal models and dictionary learning techniques can be utilized to not only classify images as belonging to one class or another, but also to detect the case when two or more of these classes co-occur with the help of augmented dictionaries. We present results comparing the classification accuracy when different image classes occur together. Practical scenarios where such an approach can be applied include forms of intrusion detection i.e., where an object of class B should not co-occur with objects of class A. An example is when there are bicyclists riding on prohibited sidewalks, or a person is trespassing a hazardous area. Mixed class detection in terms of determining semantic content can be performed in a global manner on downscaled versions of images or thumbnails. However to accurately classify an image as belonging to one class or the other, we resort to higher resolution images and localized content examination. With the help of blob tracking we can use this classification method to count objects in traffic videos. The method of feature extraction illustrated in this paper is highly suited to images obtained in practical cases, which are usually of poor quality and lack enough texture for the popular gradient based methods to produce adequate feature points. We demonstrate that by training different types of dictionaries appropriately, we can perform various tasks required for traffic monitoring.
Spatial power combining for high-power transmitters (2000)

This article surveys recent progress in the development of high-power microwave and millimeter-wave solid-state sources using spatial power-combining techniques. Several promising topologies are discussed, and four technology demonstrations are presented that have emerged from recent research in academia and industry. We also include a brief discussion of potential applications and systems insertion issues.
Master Alloys to Obtain Premixed Hardenable Powder Metal Steels (1996)

<div class="htmlview paragraph">Systems of alloys for liquid phase alloying during sintering were investigated. The solidification range of alloys of Mn-Ni-Cr-Mo-Fe and Mn-Cu-Ni was determined. Alloys with the lowest and narrowest melting range were prepared and atomized in nitrogen. Admixtures of master alloys to water-atomized, forging grade, pure iron powder were sintered at 1232°C (2250°F). After hot forging, these P/M steels exhibited hardenabilities which were 75%-90% of theoretical hardenability, as calculated from the factors for conventional steels. Alloying efficiency was further improved to 85%-100% of theoretical hardenability when additions of approximately 2% silicon and 1% rare earth misch-metal were made to the master alloys. The silicon and rare earth misch-metal additions were used to enhance diffusion and sintering. The steels obtained by premixing and sintering master alloys with pure iron powder were substantially homogeneous, had excellent microstructures, and exhibited very good tensile and impact properties. It was observed that molybdenum was the slowest diffusing element of those investigated and that manganese diffused about three times faster than molybdenum. However, it was also noted that the diffusion rate of manganese was slowed to the speed of molybdenum when both manganese and molybdenum were contained in the admixed alloy. It was decided to use a base iron powder which was prealloyed only with molybdenum to counteract the slowing down of manganese diffusion during sintering. Accordingly, an iron alloy powder containing 0.3% Mo admixed with a manganese-rich master alloy doped with silicon and rare earths produced a P/M steel which exhibited alloying efficiency approaching 100%. This led to the conclusion that liquid phase alloying is the best method for producing high density, warm-compacted P/M steels having good hardenability.</div>
Synthesis and in vitro cytotoxicity of long chain 2-amino alcohols and 1,2-diamines. (2001)

The synthesis of enantiomerically pure unsaturated long chain 1,2-diamines and amino alcohols was carried out starting from the corresponding non-natural alpha-amino acids. The in vitro cytotoxicity of the compounds prepared was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). Free 1, 2-diamines proved to be the most active compounds exhibiting IC50 values between 2.0 mM and 3.3 mM.
A spectroscopic method for the determination of optical purities of chiral, chelating diphosphines (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA spectroscopic method for the determination of optical purities of chiral, chelating diphosphinesEvan P. Kyba and Steven P. RinesCite this: J. Org. Chem. 1982, 47, 24, 4800–4801Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://doi.org/10.1021/jo00145a046RIGHTS & PERMISSIONSArticle Views87Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (287 KB) Get e-Alerts Get e-Alerts
Complexity and Self-Organization in Large Arrays of Elastic Rods in an Air Cross-Flow (2002)

Experiments on spatio‐temporal dynamics in large arrays of cantilevered elastic‐rods in uniform and stationary wind‐tunnel cross‐flow have been carried out. From 90 to 1000 steel and polycarbonate rods with gap ratios ranging from 1.0 to 2.5 are used. As the Reynolds number (based on the rod diameter) increases, a pattern with the characteristics of spatio‐temporal chaos emerges in the global behavior of the array of elastic rods. There are local and global patterns. The local patterns are composed of transient rest, linear motions and elliptical motions. In the 90‐rod experiments, a cluster‐pattern entropy measure is introduced based on these three patterns as a quantitative measure of the local complexity. Below a threshold wind velocity, no significant dynamics appears. Video images reveal that at first each rod moves individually, then clusters consisting of several rods emerge and finally global wave‐like motion takes place with higher flow velocities. Spatial patterns in the rod‐density distribution appear as more rods suffer impacts with nearest neighbors. Furthermore, these collective nonlinear motions of rods are observed and categorized into several global modes. Using accelerometer data, the rod impact rate versus flow velocity shows a power‐law scaling relation. This phenomenon may have application to plant‐wind dynamics and damage as well as fluid‐structure heat exchange systems. This experiment may also be a two dimensional analog of the impact dynamics of granular materials in a flow.
Polymer-Dispersed Antiferroelectric Liquid Crystals (2001)

Abstract An electro-optical behaviour of W-101 antiferroelectric mixture in PDLC system has been studied. It has been found that it is extremely difficult to obtain proper liquid crystal alignment inside droplets for the mixture which has not got N* phase.
The effects of time and temperature on flow cytometry enumerated live Cryptosporidium parvum oocysts (2005)

When evaluating method performance with live oocysts, both the storage temperature and time are critical factors for obtaining reliable and accurate results.
Mitral Valve Modelling in Ischemic Patients: Finite Element Analysis from Cardiac Magnetic Resonance Imaging (2010)

The goal of the present work was to develop a framework for the analysis of time-varying mitral valve (MV) geometry from cardiac magnetic resonance (CMR) imaging, and to integrate these data in a patient-specific simulation of MV closure. CMR imaging of 18 long-axis planes was performed on a healthy subject and on two ischemic patients with MV regurgitation. MV annulus geometry, leaflets surface and papillary muscles position were obtained using custom software. Hyperelastic anisotropic mechanical properties were assigned to the MV tissues, and a pressure load curve was applied to the leaflets. Results concerning healthy MV biomechanics were consistent with previous computational data. Ischemic MV models appear suitable to mimic the pathological malfunctioning of the valve. The proposed models could constitute the basis for the planning of surgical procedures.
Pseudoinversion centers in space group <i>P</i>\overline{1} and a redetermination of the crystal structure of 3,4-dimethoxycinnamic acid. A study of non-crystallographic symmetry (1991)

Il est montre que seuls vingt cristaux organiques appartenant au groupe d'espace PT ont une symetrie locale comportant des centres de pseudoinversion. On montre que l'affinement n'est pas affecte par la presence d'un pseudocentre a condition que le rapport donnee/parametre soit raisonnable (>5). Application a l'acide «3,4»-dimethoxycinnamique. C 11 H 12 O 4 cristallise dans PT avec, a la temperature ambiante, a=8,449, b=15,034, c=8,449 A, α=99,47, β=94,57, γ=101,53 o , Z=4; affinement jusqu'a R=0,041; a 173 K, a=8,412, b=14,959, c=8,341 A, α=100,28, β=94,80, γ=101,83 o , affinement jusqu'a R=0,041