Studies on Ethacrynic Acid in Patients with Refractory Edema (1965)

Article1 January 1965Studies on Ethacrynic Acid in Patients with Refractory EdemaJOHN F. MAHER, M.D., F.A.C.P., GEORGE E. SCHREINER, M.D., F.A.C.P.JOHN F. MAHER, M.D., F.A.C.P.Search for more papers by this author, GEORGE E. SCHREINER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-15 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapy of edema has been made practical by modern diuretics. The wide variety of saluretic agents in current use may be categorized into a few groups: the organic mercurials, the benzothiadiazines, carbonic anhydrase inhibitors, aldosterone antagonists, theophilline derivatives, and osmotic diuretics. Ethacrynic acid, a new and potent saluretic agent, is chemically unrelated to the agents now in use. Chemically it is 2-3 dichloro-4-(2-methylenebutyrl) phenoxyacetic acid.Preliminary studies (3-5) attest to its potency in the dog and man. We have studied this drug in patients with refractory edema to determine its effectiveness under adverse clinical and chemical conditions, to attempt...References1. MAHER JF: The use of ethacrynic acid in edema due to renal disease. Proceedings of the National Disease Foundation 1964, in press. Google Scholar2. MAHERO'CONNELLSETTERSCHREINER JFJMJGGE: Effect of ethacrynic acid on refractory edema. Clin. Res. 12: 70, 1964. Google Scholar3. BAERMICHAELSONRUSSOBEYER JEJKHJKH: 2,3-Dichloro4-(2-methylenebutyrl)-phenoxyacetic acid. I. A novel and potent diuretic-saluretic agent. Fed. Proc. 22: 598, 1963. Google Scholar4. FOLTZ EL: Preliminary clinical observations with an aryloxyacetic. Ibid., p. 598. Google Scholar5. CANNONAMESLARAGH PJRPJH: Methylene butyrl-phenoxyacetic acid. Novel and potent natriuretic and diuretic agent. JAMA 185: 854, 1963. CrossrefMedlineGoogle Scholar6. SCHREINER GE: The Nephrotic Syndrome, in Diseases of the Kidney, edited by STRAUSS, M., WELT, L., Little Brown & Co., Boston, 1963, pp. 335-345. Google Scholar7. GENTZKOW CJ: An accurate method for the determination of blood urea nitrogen by direct Nesslerization. J. Biol. Chem. 143: 531, 1942. CrossrefGoogle Scholar8. BONSNESTAUSSKY RWHH: On the colorimetric determinations of creatinine by the Jaffe reaction. J. Biol. Chem. 158: 581, 1945. CrossrefGoogle Scholar9. BROWN H: Determination of uric acid in blood. J. Biol. Chem. 68: 123, 1926. CrossrefGoogle Scholar10. GOLDBERGMCCURDYFOLTZBLUEMLE MDKELLW: Effects of ethacrynic acid (a new saluretic agent) on renal diluting and concentrating mechanisms. Evidence for site of action in the loop of Henle. J. Clin. Invest. 43: 201, 1964. CrossrefMedlineGoogle Scholar11. MANN J: Personal communication. Google Scholar12. BRAUNLILIENFIELD WELS: Renal hemodynamic effect of hypertonic mannitol infusions. Proc. Soc. Exp. Biol. Med. 114: 1, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN F. MAHER, M.D., F.A.C.P.; GEORGE E. SCHREINER, M.D., F.A.C.P.Affiliations: Washington, D. C.From the Department of Medicine, Georgetown University School of Medicine and the Renal and Electrolyte Division, Georgetown University Hospital, Washington, D. C.This study was supported in part by the John A. Hartford Foundation, Inc. and the Georgetown University Kidney Research Fund, Washington, D. C. Part of this study was carried out in the Georgetown University Clinical Study Unit supported by Clinical Study Grant 5 MO 1 FR 00060-04 (FR 60) from the General Clinical Research Centers branch of the National Institutes of Health, U. S. Public Health Service, Bethesda, Md.The preliminary results of this study were presented at the annual meetings of the National Kidney Disease Foundation, Swampscott, Mass., Oct. 11, 1963 (1) and the Southern Society for Clinical Investigation, New Orleans, La., Jan. 24, 1964 (2).Requests for reprints should be addressed to John F. Maher, M.D., Georgetown University Hospital, 3800 Reservoir Road, N.W., Washington, D. C. 20007. 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GEOFFREY WALKER, M.B.Diuretic drugs in patients with impaired renal functionEffects of Ethacrynic Acid on Renal Function in ManEthacrynic acid 1 January 1965Volume 62, Issue 1Page: 15-29KeywordsDiureticsEdemaExcretionHospital medicinePrevention, policy, and public healthRenal diseasesRenal ischemiaResearch fundingUreaUric acid ePublished: 1 December 2008 Issue Published: 1 January 1965 PDF downloadLoading ...