gebhart/patrepeval huggingface dataset:
The Src-like Adaptor Protein 2 Regulates Colony-stimulating Factor-1 Receptor Signaling and Down-regulation (2007)

Src-like adaptor protein 2 (SLAP-2) is a hematopoietic adaptor protein previously implicated as a negative regulator of T-cell antigen receptor (TCR)-mediated signaling. SLAP-2 contains an SH3 and an SH2 domain, followed by a unique carboxyl-terminal tail, which is important for c-Cbl binding. Here we describe a novel role for SLAP-2 in regulation of the colony-stimulating factor 1 receptor (CSF-1R), a receptor tyrosine kinase important for growth and differentiation of myeloid cells. SLAP-2 co-immunoprecipitates with c-Cbl and CSF-1R in primary bone marrow-derived macrophages. Using murine myeloid cells expressing CSF-1R (FD-Fms cells), we show that SLAP-2 is tyrosine-phosphorylated upon stimulation with CSF-1 and associates constitutively with both c-Cbl and CSF-1R. In addition, we show that expression of a dominant negative form of SLAP-2 impairs c-Cbl association with the CSF-1R and receptor ubiquitination. Impaired c-Cbl recruitment also correlated with changes in the kinetics of CSF-1R down-regulation and trafficking. CSF-1-mediated differentiation of FD-Fms cells and activation of downstream signaling events was also enhanced in cells stably expressing dominant negative SLAP-2. Together, these results demonstrate that SLAP-2 plays a role in c-Cbl-dependent down-regulation of CSF-1R signaling.
Regulation of the acute phase and immune responses (1989)

This book contains the conference entitled Regulation of the acute phase and immune responses: Interleukin-L. Topics covered include: Interferon-B{sub 2}/26kDa Protein, Regulation of acute phase liver gene expression, and Genetics and regulation of expression of IL-6.
Equilibrium bifurcations and chaotic transitions in coupled microlaser lattices (2004)

Analytic and simulation studies for the steady-state equilibria and bifurcations of coupled microlaser arrays are described. Lateral cavity interactions affect the gain in each cavity, leading to active photonic lattice behavior, equivalent to a nonlinear coupled oscillator lattice. The coupled-cavity rate equations are employed to follow the coherent photon and carrier population in each lattice site. Fixed-point-type steady states, of constant lattice phase shift, result for low coupling strengths; the radiation envelope for these states conforms with a periodic Bloch state over the array. Bifurcations to limit cycles of increasing complexity occur at higher coupling via period doubling sequences. The associated spatial patterns of photon and carrier lattice distribution resemble photonic convection cells. Limit cycles of different periods, emanating mathematically from different original fixed points, coexist at high strengths, each one accessible from different initial conditions. The multiplicity of possible limit cycles in systems with many degrees of freedom (number of lattice sites) combined with changes in their accessibility from initial conditions offers new insights to chaotic transitions, compared to low dimensionality paradigms.
Serotonin-related genotypes but not diagnosis of social anxiety disorder predict amygdala responsiveness to angry faces. (2008)

Serotonin-related genotypes but not diagnosis of social anxiety disorder predict amygdala responsiveness to angry faces.
Discovery of the Central Excess Brightness in Hard X‐Rays in the Cluster of Galaxies Abell 1795 (1998)

Using the X-ray data from ASCA, spectral and spatial properties of the intracluster medium (ICM) of the cD cluster Abell 1795 are studied up to a radial distance of D12@ (D1.3 kpc). The ICM temh 50 ~1 perature and abundance are spatially rather constant, although the cool emission component is recon-rmed in the central region. The azimuthally averaged radial X-ray surface brightness proles are very similar between soft (0.73 keV) and hard (310 keV) energy bands, and neither can be tted with a single-b model due to a strong data excess within D5@ of the cluster center. In contrast, double-b models can successfully reproduce the overall brightness proles both in the soft and hard energy bands, as well as that derived with the ROSAT PSPC. Properties of the central excess brightness are very similar over the 0.210 keV energy range spanned by ROSAT and ASCA. Thus, the excess X-ray emission from the core region of this cluster is conrmed for the rst time in hard X-rays above 3 keV. This indicates that the shape of the gravitational potential becomes deeper than the King-type one toward the cluster center. Radial proles of the total gravitating matter, calculated using the double-b model, reveal an excess mass of D3 ] 1013 within D150 kpc of the cluster center. This suggests a hierarchy in M _ h 50 ~1 the gravitational potential corresponding to the cD galaxy and the entire cluster.
Scalable high-power, high-speed CW VCSEL arrays (2009)

A demonstration of a high-power, high-speed 980 nm vertical-cavity surface-emitting laser array with continuous-wave power of greater than 120 mW and frequency response over 7.5 GHz at room temperature is reported. Experimental results show that copper plating the array elements and flip-chip bonding provides effective thermal management as well as offering uniform current distribution at microwave frequencies. This is verified by the radial dependence of modulation bandwidth. These arrays may be useful for short-range light detection and ranging or free-space optical communications systems.
Low-Level Detection of a Bacillus Anthracis Simulant using Love-Wave Biosensors on 36 Degree YX LiTaO3 (2003)

Crucial to low-level detection of biowarfare agents in aqueous environments is the mass sensitivity optimization of Love-wave acoustic sensors. The present work is an experimental study of 36{sup o} YX cut LiTaO{sub 3} based Love-wave devices for detection of pathogenic spores in aqueous conditions. Given that the detection limit (DL) of Love-wave based sensors is a strong function of the overlying waveguide, two waveguide materials have been investigated, which are polyimide and polystyrene. To determine the mass sensitivity of Love-wave sensor, bovine serum albumin (BSA) protein was injected into the Love-wave test cell while recording magnitude and phase shift across each sensor. Polyimide had the lowest mass detection limit with an estimated value of 1-2 ng/cm{sup 2}, as compared to polystyrene where DL = 2.0 ng/cm{sup 2}. Suitable chemistries were used to orient antibodies on the Love-wave sensor using adsorbed protein G. The thickness of each biofilm was measured using ellipsometry from which the surface concentrations were calculated. The monoclonal antibody BD8 with a high degree of selectivity for anthrax spores was used to capture the non-pathogenic simulant B. thuringiensis B8 spores. Bacillus Subtilis spores were used as a negative control to determine whether significant non-specific binding would occur. Spore aliquots were prepared using an optical counting method, which permitted removal of background particles for consistent sample preparation. This work demonstrates that Love-wave devices can be used to detect B. anthracis simulant below reported infectious levels.
Lateral ankle ligament injury : an experimental and clinical study (1984)

textabstractSport has become one of the most popular methods of spending freetime and
consequently is of great social importance.
fn recent studies concerning sports injuries in the Netherlands (BoersmaSIUtter
et al. - 1979, v.Rens 1982) it was estimated that about 20% of all
registered sportsmen sustain a sports injury every year, resulting in about
800.000 sports injuries in one year.
Ankle sprain was found to be the most frequent injury, accounting for 18-21%
of all sports injuries. Accordingly, ankle sprain is diagnosed in about 150.000
sportsmen every jear.
The medical consequences of this finding were already clearly recognized in
1975 by Cedell as he stated: 11 Ankle injuries constitute a quantitative therapeutic
problem that must be solved in the best way considering the ava-Ilable
economic and medical resources. However, the demand for higher quality in
the treatment must not be omitted.
A reliable diagnostic procedure, providing an accurately specified diagnosis
would enable an appropriate therapy for ankle sprains. Consequently, all
kinds of sequelae, like chronic sprain, ankle instability, damage to the articular
cartilage and osteo-arthrosis, resulting from misdiagnosis and mistreatment,
can be prevented (O'Donoghue - 1958, Blain et a!. 1962, Grand
1973, Tenino - 1973, v .Barth - 1975, Fulp - 1975, Kooyman and Ponsen
1976, McCluskey et al. - 1976, Seiler and Holzrichter 1977, Stepanuk -1977,
Speeckaert - 1978, Jungmichel - 1978, Tausch - 1978).
The study presented in this thesis was set up to evaluate the diagnostic
significance of arthrography in diagnosing recent ankle ligament ruptures and
to assess the value of early surgical repair of ruptured lateral ankle ligaments
as a method of treatment, with the above-mentioned considerations in mind.
The two suppositions underlying this study are:
1. The value of the anterior talofibular ligament in stabilizing the ankle
joint is generally underestimated.
2. Early surgical repair can improve the process of ligament healing by
providing adequate coaptation of ligament ends, thereby leading to early
functional recovery.
The investigations were prompted by the promising results of surgical repair lateral ankle ligament ruptures, obtained in 63 patients within a pilot study,
carried out in the period of May 1977 until April 1979 at the surgical department
of the Zeeweg Hospital IJmuiden (Head: F. Schreuder M.D.).
The results of a prospective clinical study, carried out at the surgical department
of the St. Hippolytus Hospital Delft (Head: W.M. Oosterwijk M.D.
Ph.D.) will be compared to the results of other therapeutic modalities as
found in literature and will be combined with the findings of an experimental
study on the process of ligament healing, carried out at the Laboratory of
Experimental Surgery at the Erasmus University Rotterdam, under the supervision
of Prof. D.L. Westbroek M.D.
Influence of the Luminance Signal and Red-Green and Yellow-Blue Opponent Chromatic Signals in Figural- Stimuli Stereograms (1995)

The influence of color signals on stereopsis has been studied using figural-stimuli stereograms with variations introduced according to the opponent chromatic channels (red-green and yellow-blue), derived from Boynton's color-vision model. We used wallpaper stereograms, which enable the rank-order disparity ranges of the chromatic and luminance signals to be compared with the rank-order disparity range of proximity, a particular spatial configuration of the stereogram in which there are no variations in chromaticity and/or luminance. The results indicate that both chromatic signals contribute to stereopsis as does the luminance signal, contradicting the model of Hubel and Livingstone. The results also show there are no clear dependencies upon the kind of signal processed, as luminance and chromatic variations are processed with the same efficiency.
Kinetic Comparison of Ethylene and Propylene Polymerization Reactions with Ziegler—Natta Catalysts (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
The use of [2,3] sigmatropic rearrangements for the specific ortho-substitution of polycyclic aromatic amines. The methylation of naphthylamines and the synthesis of 1H-benz[g]indoles and 3H-benz[e]indoles (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe use of [2,3] sigmatropic rearrangements for the specific ortho-substitution of polycyclic aromatic amines. The methylation of naphthylamines and the synthesis of 1H-benz[g]indoles and 3H-benz[e]indolesPaul G. Gassman and William N. SchenkCite this: J. Org. Chem. 1977, 42, 20, 3240–3243Publication Date (Print):September 1, 1977Publication History Published online1 May 2002Published inissue 1 September 1977https://doi.org/10.1021/jo00440a008Request reuse permissionsArticle Views562Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (527 KB) Get e-Alertsclose Get e-Alerts
Structural insights into the role of iron–histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins (2014)

Heme-nitric oxide/oxygen (H-NOX) binding domains are a recently discovered family of heme-based gas sensor proteins that are conserved across eukaryotes and bacteria. Nitric oxide (NO) binding to the heme cofactor of H-NOX proteins has been implicated as a regulatory mechanism for processes ranging from vasodilation in mammals to communal behavior in bacteria. A key molecular event during NO-dependent activation of H-NOX proteins is rupture of the heme-histidine bond and formation of a five-coordinate nitrosyl complex. Although extensive biochemical studies have provided insight into the NO activation mechanism, precise molecular-level details have remained elusive. In the present study, high-resolution crystal structures of the H-NOX protein from Shewanella oneidensis in the unligated, intermediate six-coordinate and activated five-coordinate, NO-bound states are reported. From these structures, it is evident that several structural features in the heme pocket of the unligated protein function to maintain the heme distorted from planarity. NO-induced scission of the iron-histidine bond triggers structural rearrangements in the heme pocket that permit the heme to relax toward planarity, yielding the signaling-competent NO-bound conformation. Here, we also provide characterization of a nonheme metal coordination site occupied by zinc in an H-NOX protein.
Electrotonic Remodeling Following Myocardial Infarction: A Link to Sudden Cardiac Death? (2007)

A potential mechanism for ventricular fibrillation (VF) and sudden cardiac death following myocardial infarction (MI) is the remodeling of repolarization currents, leading to increased action potential duration and dispersion of repolarization. Recently, it has been shown in vitro that electrotoni c loading, resulting from heterogene ities in the ventricle, triggers the remodelin g of the Ito current. Thus, we studied electrotonic coupling in the post-MI heart, as measured by myocardial electrical impedance (MEI). Infarcts were induced in dogs by LAD coronary artery ligation. The dogs were instrumented with MEI electrodes in normal (LCX and LAD) and infarcted myocardium. After recovery, MEI was measured in awake-unsedated animals 1, 2, and 7 days after MI. Subsequently, VF-susceptibility was tested by a 2-min LCX occlusion during submaximal exercise; 11 animals developed VF (susceptible, S) and 10 did not (resistant, R). Healing myocardial infarct had significantly lower MEI than normal myocardium (see figure). This difference was steady by day 2 post-MI (287±8.5 vs. 425±16.7 Ω, ANOVA P<0.05). Furthermore, significant differences were observed between resistant and susceptible animals: One week after MI, susceptible dogs had a wider electrotonic disparity between remote myocardium and scar (R: 86.5±20.7 vs. S: 183.7±12.6Ω, P<0.05). These data suggest that electrotonic remodeling following MI may contribute to malignant ventricular arrhythmias.
A CONTRIBUTION TO THE STUDY OF THE CONSTITUTION OF THE HYDROXYAZO COMPOUNDS. THE ACTION OF UNSYMMETRICAL BENZOYLPARATOLYLHYDRAZINE UPON BENZOQUINONE AND ITS HOMOLOGS. (1915)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA CONTRIBUTION TO THE STUDY OF THE CONSTITUTION OF THE HYDROXYAZO COMPOUNDS. THE ACTION OF UNSYMMETRICAL BENZOYLPARATOLYLHYDRAZINE UPON BENZOQUINONE AND ITS HOMOLOGS.William McPherson and George Weatherworth StrattonCite this: J. Am. Chem. Soc. 1915, 37, 4, 906–915Publication Date (Print):April 1, 1915Publication History Published online1 May 2002Published inissue 1 April 1915https://pubs.acs.org/doi/10.1021/ja02169a020https://doi.org/10.1021/ja02169a020research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ARTEMIS-2: an application development experiment with the HELIOS environment. (1994)

A medical application is a highly complex system that embraces many data types and a very large number of data processing functions and methods. The development of integrated software engineering environments has deeply changed the conception of applications and the profile of the application developers. In this paper, we address the problem of the development process of a specific multimedia application, called ARTEMIS, within the distributed HELIOS environment. The application is intended to manage information about hypertensive patients, in particular, retrieval and display of administrative, clinical and biological data and display and analysis of digital angiography images and medical reports. The objective is to show how the developer can use, customize and organize the services HELIOS provides. A particular focus is set on reuse strategies and integration during the development process. A scenario has been realized and illustrates the current state of the application. The discussion focuses on the advantages of such distributed environments in medical application development.
Calcium and the prevention of colon cancer (1995)

Chemoprevention studies utilizing calcium have now progressed from basic measurements to clinical trials. Calcium's effects on epithelial cells have demonstrated decreased proliferation and induced cell differentiation with increasing levels of calcium in vitro, similar in vivo effects in rodent and human colon, and decreased carcinogen-induced colonic tumor formation in rodents. Current studies are attempting to inhibit colonic adenoma formation in human subjects. Most but not all epidemiologic studies also link increased dietary calcium with a decreased risk of colon cancer. In animal models, supplemental dietary calcium has decreased mammary epithelial cell hyperplasia and hyperproliferation and colonic cell hyperproliferation when the latter was induced by bile acids, fatty acids, and partial resection of the small intestine. Supplemental dietary calcium also decreased carcinogen-induced colonic tumors in several rodent models. In normal mice, and in mice carrying a targeted apc gene mutation, we recently increased colonic polypoid hyperplasias by a Western-style diet containing low calcium and vitamin D. In human subjects at increased risk for colon cancer, oral calcium supplementation significantly reduced colonic epithelial cell proliferation in most of the studies, including four randomized clinical trials. These studies have now progressed to short-term human clinical trials, including trials that measure the regrowth of transformed adenoma cells. Short-term adenoma-regrowth clinical trials, however, are limited in their ability to measure whether chemopreventive agents inhibit early genotoxic events, abnormal cellular metabolic activities involved in tumor promotion over many years, or the progression of adenoma cells to carcinoma.
ChemInform Abstract: ROTATION EFFECTS ON THE ISOTHERMAL GROWTH OF (EU, Y)3 (FE, GA)5O12 MAGNETIC BUBBLE FILMS BY LIQUID PHASE EPITAXY (1974)

Abstract Ein Flüssigkeitsepitaxieverfahren wird beschrieben, bei dem Filme des Granats (Eu,Y) 3 (Fe,Ga) 5 O 12 aus PbO‐B 2 O 3 ‐Fe 2 O 3 ‐Schmelzen auf axial in einer horizontalen Ebene rotierende Gd 3 Ga 5 O 12 ‐Substrate aufgezüchtet werden.
Murine Lewis Lung Carcinoma-Derived Endothelium Expresses Markers of Endothelial Activation and Requires Tumor-Specific Extracellular Matrix In Vitro (2003)

The purpose of the study was to identify characteristics specific to tumor-derived endothelium that may be important in tumor biology, or for the development of targeted therapeutics or imaging agents. Normal C57Bl/6 murine heart or lung endothelium, or C57Bl/6 murine Lewis lung carcinoma tumor-derived endothelium was isolated from excised tissues using specific antibodies. The endothelium was cultured using either native fibronectin, or the oncofetal form of fibronectin. Cell surface adhesion molecule expression was analyzed by flow cytometry, and the cellular distribution of specific molecules was examined using indirect immunofluorescence staining. Oncofetal fibronectin was critical for maintaining the phenotype of tumor-derived endothelium, which demonstrated an elongated morphology in vitro, with few cell-cell contacts. They expressed high levels of CD31, CD102, and vascular endothelial cadherin, and constitutively expressed CD62E, CD54, and CD106, indicating an "activated" phenotype. Moreover, they expressed significantly greater levels of Sca-1 and Flk-1 than normal murine endothelium. Cellular distribution of CD31, beta-catenin, and CD106 in tumor-derived endothelium was not continuous at cell borders, as observed in cultures of murine heart endothelium. In conclusion, Lewis lung carcinoma-derived tumor endothelium exhibits a specific phenotype in vitro, distinct from normal endothelium, and could be used as an in vitro tool for developing targeted agents.
Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb (2017)

Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied. Efficiency of total plasma exchange to remove suPAR was determined. CytoSorb hemoadsorption caused a 27.33% reduction of the suPAR level in a single treatment, whereas total plasma exchange showed a suPAR level reduction of 25.12% (n = 3; 95% confidence interval, 0.2777-0.8090; P < 0.01), which may indicate therapeutic potential in the treatment of primary FSGS and its recurrence in a kidney transplant.