gebhart/patrepeval huggingface dataset:
Multifaceted aspects of chunking enable robust algorithms (2014)

Sequence production tasks are a standard tool to analyze motor learning, consolidation, and habituation. As sequences are learned, movements are typically grouped into subsets or chunks. For example, most Americans memorize telephone numbers in two chunks of three digits, and one chunk of four. Studies generally use response times or error rates to estimate how subjects chunk, and these estimates are often related to physiological data. Here we show that chunking is simultaneously reflected in reaction times, errors, and their correlations. This multimodal structure enables us to propose a Bayesian algorithm that better estimates chunks while avoiding overfitting. Our algorithm reveals previously unknown behavioral structure, such as an increased error correlations with training, and promises a useful tool for the characterization of many forms of sequential motor behavior.
Unitary premotor drives and modular reflex primitives in frog spinal cord (2004)

Modular organization of reflexes and premotor drives in frog spinal cord can be revealed in a number of ways. Isometric force-field measurements, electromyogram decomposition with statistical methods, and direct reflex manipulation all support a small number of elements supporting spinal behaviors. The central neural circuits that support the modules indicated by these methods are not well understood. A current focus of our laboratory is to begin to examine activity patterns that support modular common drives. To examine activity we are using a Bionic Technologies Cerebus 128 channel system with real time (1KHz 1ms resolution) delivery of up to 2 resolved spikes spikes per channel. Neuralynx Cyborg drives, microwire, and tetrodes are being tested for recording with this system. Activity is elicited by reflex stimulation to induce wipe movements or muscle vibration. We are also testing activity induction by photolytic uncaging of glutamate in the preparation, a technique with the advantage of no electrical artefact but perhaps reduced temporal precision. If recruited by microstimulation or other means a modular spinal circuitry may in the future support powerful neuroprosthetic designs.
Phenotypic effects of concomitant insensitive acetylcholinesterase ( ace-1 R ) and knockdown resistance ( kdr R ) in Anopheles gambiae : a hindrance for insecticide resistance management for malaria vector control (2014)

Malaria is endemic in sub-Saharan Africa with considerable burden for human health. Major insecticide resistance mechanisms such as kdr R and ace-1 R alleles constitute a hindrance to malaria vector control programs. Anopheles gambiae bearing both kdr and ace-1 resistant alleles are increasingly recorded in wild populations. In order to maintain the efficacy of vector control strategies, the characterization of concomitant kdr and ace-1 resistance, and their pleiotropic effects on malaria vector phenotype on insecticide efficacy are important. Larval and adult bioassays were performed with different insecticide classes used in public health following WHO standard guidelines on four laboratory Anopheles gambiae strains, sharing the same genetic background but harboring distinct resistance status: KISUMU with no resistance allele; ACERKIS with ace-1 R allele; KISKDR with kdr R allele and ACERKDRKIS with both resistance alleles’ ace-1 R and kdr R . Larval bioassays indicate that the homozygote resistant strain harboring both alleles (ACERKDRKIS) displayed slightly but significantly higher resistance level to various insecticides like carbamates (bendiocarb, p < 0.001; propoxur, p = 0.02) and organophosphates (chlorpyriphos-methyl, p = 0.002; fenitrothion, p < 0.001) when compared to ACERKIS strain. However, no differences were recorded between ACERKDRKIS and KISKDR resistance level against permethrin (Pyrethroid, p = 0.7) and DDT (Organochlorine, p = 0.24). For adult bioassays, the percentages of mosquitoes knocked down were significantly lower for ACERKDRKIS than for KISKDR with permethrin (p = 0.003) but not with deltamethrin. The percentage of mortality from adult bioassays was similar between ACERKDRKIS and ACERKIS with carbamates and organophosphates, or between ACERKDRKIS and KISKDR with pyrethroid and DDT. Concerning acetylcholinesterase enzyme, ACERKDRKIS strain showed similarAChE1 activity than that of ACERKIS. The presence of both kdr R and ace-1 R alleles seems to increase the resistance levels to both carbamate and organophosphate insecticides and at operational level, may represent an important threat to malaria vector control programs in West Africa.
S0402-2-2 Microstructural and wear properties of sintered magnesium composite reinforced with CNT-Mg_2Si/MgO (2010)

Porous silica (SiO_2) particles originated from rice husks were coated with carbon nanotubes (CNTs) by using zwitterionic surfactant solution via wet mixing process. Elemental mixture of this hybrid particle and pure Mg powder were consolidated by spark plasma sintering (SPS) process. DTA profile of the elemental mixture powders indicated that a remarkable exothermic heat started at 727K due to the reaction of Mg-SiO_2 to synthesize magnesium silicide (Mg_2Si) intermetallic compounds in solid-state. There was no reaction between SiO_2 and CNTs in DTA result. With increasing the content of CNT/SiO_2 hybrid powders, the relative intensity of Mg_2Si and MgO peaks gradually increased, and resulted in the increment of macro-hardness of the sintered Mg composites. The friction coefficient of the composite under dry condition gradually decreased with increase in the hybrid powders. This is because the abrasive wear was prevented by uniform dispersion of Mg_2Si hard particles in the matrix and the bearing effect and self-lubricant property of nanotubes remarkably reduced the friction between the composite and the counter material (SUS304).
Winning The Transfer Learning Track of Yahoo!’s Learning To Rank Challenge with YetiRank (2010)

The problem of ranking the documents according to their relevance to a given query is a hot topic in information retrieval. Most learning-to-rank methods are supervised and use human editor judgements for learning. In this paper, we introduce novel pairwise method called YetiRank that modifies Friedman’s gradient boosting method in part of gradient computation for optimization and takes uncertainty in human judgements into account. Proposed enhancements allowed YetiRank to outperform many state-of-the-art learning to rank methods in offline experiments as well as take the first place in the second track of the Yahoo! learning-to-rank contest. Even more remarkably, the first result in the learning to rank competition that consisted of a transfer learning task was achieved without ever relying on the bigger data from the “transfer-from ” domain.
133Ba as a gamma-ray surrogate source for 1kg HEU and 10g 239Pu and 252Cf as a Neutron Surrogate for Pu (2004)

Monte Carlo was performed for the purpose of relating gamma-ray signal strength from 1kg of HEU and 10g of {sup 239}Pu (as described in the ASTM standards) to the radiation emitted from an amount of {sup 133}Ba. A determination was made on the amount of {sup 133}Ba that could act as a surrogate for the specified amounts of HEU and Pu. {sup 133}Ba is not the ideal source to use as a surrogate for HEU because of its higher energies. {sup 133}Ba was chosen as the surrogate since it has a half-life of 10.54 years, rather then the more ideal surrogate of {sup 57}Co which has a half-life of 271 days. A similar Monte Carlo was performed for the purpose of relating neutron signal strength from 200g of Pu (as described in the ASTM standards) to the radiation emitted from an amount of shielded {sup 252}Cf. A determination was made on the amount of {sup 252}Cf necessary to act as a surrogate for the 200g of Pu. An ASTM standard source is a metallic sphere, cube, or right cylinder of SNM having maximum self-attenuation of its emitted radiation. For plutonium, the source should be at least 93% {sup 239}Pu, less than 6.5% {sup 240}Pu, and less than 0.5% impurities. A cadmium filter of at least 0.08cm thick should be used to reduce the impact of {sup 241}Am. For uranium, the source should contain at least 95% {sup 235}U and less than 0.25% impurities. For neutron detector testing, the neutron source shall be placed in a lead shielding container that reduces the gamma radiation from the source to 1% of its unshielded value.
MP41-20 THE ASSOCIATION OF PREOPERATIVE ASPIRIN USE WITH SURVIVAL FOLLOWING RADICAL CYSTECTOMY (2018)

INTRODUCTION AND OBJECTIVES: Quality of life is an important consideration after complex cancer surgery. Data on quality of life after radical cystectomy are still scarce. Our aim was to analyse the impact of robotic assisted radical cystectomy (RARC) and urinary diversion with multimodal enhanced recovery protocol on peri-operative outcomes and postoperative health-related quality of life (HRQOL) at multiple prospective time points.
Copy Number Variation in<i>TAS2R</i>Bitter Taste Receptor Genes: Structure, Origin, and Population Genetics (2016)

Bitter taste receptor genes (TAS2Rs) harbor extensive diversity, which is broadly distributed across human populations and strongly associated with taste response phenotypes. The majority of TAS2R variation is composed of single-nucleotide polymorphisms. However, 2 closely positioned loci at 12p13, TAS2R43 and -45, harbor high-frequency deletion (Δ) alleles in which genomic segments are absent, resulting in copy number variation (CNV). To resolve their chromosomal structure and organization, we generated maps using long-range contig alignments and local sequencing across the TAS2R43-45 region. These revealed that the deletion alleles (43Δ and 45Δ) are 37.8 and 32.2kb in length, respectively and span the complete coding region of each gene (~1kb) along with extensive up- and downstream flanking sequence, producing separate CNVs at the 2 loci. Comparisons with a chimpanzee genome, which contained intact homologs of TAS2R43, -45, and nearby TAS2Rs, indicated that the deletions evolved recently, through unequal recombination in a cluster of closely related loci. Population genetic analyses in 946 subjects from 52 worldwide populations revealed that copy number ranged from 0 to 2 at both TAS2R43 and TAS2R45, with 43Δ and 45Δ occurring at high global frequencies (0.33 and 0.18). Estimated recombination rates between the loci were low (ρ = 2.7×10(-4); r = 6.6×10(-9)) and linkage disequilibrium was high (D' = 1.0), consistent with their adjacent genomic positioning and recent origin. Geographic variation pointed to an African origin for the deletions. However, no signatures of natural selection were found in population structure or integrated haplotype scores spanning the region, suggesting that patterns of diversity at TAS2R43 and -45 are primarily due to genetic drift.
Resilience and Burnout Among Physicians and the General US Working Population (2020)

The findings of this national survey study suggest that physicians exhibited higher levels of resilience than the general working population in the US. Resilience was inversely associated with burnout symptoms, but burnout rates were substantial even among the most resilient physicians. Additional solutions, including efforts to address system issues in the clinical care environment, are needed to reduce burnout and promote physician well-being.
Channel modeling and testing of wireless transmission for underground in-pipe leak and material loss detection (2017)

A systematic real-time methodology is adopted for leak detection in underground buried pipes. The wireless communication system is used to analyze the system performance based on the received power by monopole antenna deployed at the receiving side. Instrumentation designed for underground measurement and control such as leak and materials loss detection needs wireless communications to aboveground in both ways and in real-time mode. This constitutes one of the timely and challenging issues of battery-operated systems. The purpose of this work is to characterize the radio transmission between underground buried pipes and base station using multi-layer media including both theoretical and experimental approaches by utilizing various modulation schemes. The objective is to identify the range of operating communication frequencies having lower energy loss, lower resulting bit error rate, and the power needed to transfer packets designed to carry data through the media. This will support the on-device power management to secure large autonomy operations. Experimental tests have shown that the overall received energy was mixed with ambient energy if the latter is sent at the same frequency and that the optimum frequency range used to transmit energy was rather at low frequency range of 100–200 MHz. Keywords: Wireless communication; in-pipe leak; material loss; sensor network; buried pipes
Error-free programmable multi-wavelength pulse oscillator based on self-frequency shift of Raman soliton (2004)

An error-free wavelength tunable, low-noise (<−135 dBc/Hz: RIN) and high-wavelength stable programmable multi-wavelength pulse oscillator based on the self-frequency shift of Raman soliton has been demonstrated. Only selected multi-wavelength pulses with a tuning range of about 50 nm are generated with a clock rate of 9.95 GHz at each wavelength channel.
Computation of the linear viscoelastic relaxation spectrum from experimental data (1997)

Accurate and reliable determination of the linear viscoelastic relaxation spectrum is a critical step in the application of any constitutive equation. The experimental data used to determine the relaxation spectrum always include noise and are over a limited time or frequency range, both of which can affect the determination of the spectrum. Regularization with quadratic programming has been used to derive the spectrum; however, because both the experimental data and the spectrum change by more than an order of magnitude, the input data and the spectrum are normalized in order for the numerical procedure to be accurate. Accurate determination of the relaxation spectrum requires that the spectrum extend about two logarithmic decades on either side of the frequency range of the input data. The spectrum calculated from G′ alone is more accurate at shorter relaxation times, while that from G′ data alone is obtained from a combination of G′ and G′ data, blended in the manner described herein. Comparison with existing methods in the literature shows a consistently improved performance of the present method illustrated with both model as well as experimental data. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 64: 2177–2189, 1997
A novel and simple method for endotracheal intubation of mice (2007)

Endotracheal intubation in mice is necessary for experiments involving intratracheal instillation of various substances, repeated pulmonary function assessments and mechanical ventilation. Previously described methods for endotracheal intubation in mice require the use of injection anaesthesia to immobilize the animal during the intubation procedure or the use of a volatile anaesthetic prior to intubation for immobilization. With these methods, the control of anaesthetic depth during the intubation procedure is absent. We describe a method for simple and rapid intratracheal intubation in mice for mechanical ventilation, using a self-built plastic support to facilitate the intubation procedure. General anaesthesia is maintained by means of inhalation through a non-rebreathing circuit connected to the plastic support. This set-up gives the operator control of anaesthetic depth and sufficient time to perform the intubation procedure. A purpose-made laryngoscopic blade is used to facilitate the intubation tube entering the trachea. The blade of the purpose-made laryngoscope is constructed as a retraction guide and is curved for easy handling. Under direct vision, the epiglottis is gently lifted by the laryngoscopic blade while the intubation tube is pushed into the trachea. Following this novel intubation technique, we were able to mechanically ventilate mice for at least 2 h without severely disturbing blood gases. Histological evaluation of the lungs and microscopic evaluation of the trachea and larynx showed no signs of trauma related to the intubation technique or mechanical ventilation.
Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide (1996)

The rapid and spontaneous interaction between superoxide (O2-.) and nitric oxide (NO) to yield the potent oxidants peroxynitrite (ONOO-) and peroxynitrous acid (ONOOH), has been suggested to represent an important pathway by which tissue may be injured during inflammation. Although several groups of investigators have demonstrated substantial oxidizing and cytotoxic activities of chemically synthesized ONOO-, there has been little information available quantifying the interaction between O2-. and NO in the absence or the presence of redox-active iron. Using the hypoxanthine (HX)/xanthine oxidase system to generate various fluxes of O2-. and H2O2 and the spontaneous decomposition of the spermine/NO adduct to produce various fluxes of NO, we found that in the absence of redox-active iron, the simultaneous production of equimolar fluxes of O2-. and NO increased the oxidation of dihydrorhodamine (DHR) from normally undetectable levels to approximately 15 microM, suggesting the formation of a potent oxidant. Superoxide dismutase, but not catalase, inhibited this oxidative reaction, suggesting that O2-. and not hydrogen peroxide (H2O2) interacts with NO to generate a potent oxidizing agent. Excess production of either radical virtually eliminated the oxidation of DHR. In the presence of 5 microM Fe+3-EDTA to insure optimum O2-.-driven Fenton chemistry, NO enhanced modestly HX/xanthine oxidase-induced oxidation of DHR. As expected, both superoxide dismutase and catalase inhibited this Fe-catalyzed oxidation reaction. Excess NO production with respect to O2-. flux produced only modest inhibition (33%) of DHR oxidation. In a separate series of studies, we found that equimolar fluxes of O2-. and NO in the absence of iron only modestly enhanced hydroxylation of benzoic acid from undetectable levels to 0.6 microM 2-hydroxybenzoate. In the presence of 5 microM Fe+3-EDTA, HX/xanthine oxidase-mediated hydroxylation of benzoic acid increased dramatically from undetectable levels to 4.5 microM of the hydroxylated product. Superoxide dismutase and catalase were both effective at inhibiting this classic O2-.-driven Fenton reaction. Interestingly, NO inhibited this iron-catalyzed hydroxylation reaction in a concentration-dependent manner such that fluxes of NO approximating those of O2-. and H2O2 virtually abolished the hydroxylation of benzoic acid. We conclude that in the absence of iron, equimolar fluxes of NO and O2-. interact to yield potent oxidants such as ONOO-/ONOOH, which oxidize organic compounds. Excess production of either radical remarkably inhibits these oxidative reactions. In the presence of low molecular weight redox-active iron complexes, NO may enhance or inhibit O2-.-dependent oxidation and hydroxylation reactions depending upon their relative fluxes.
Optic nerve haemangioblastoma mimicking a planum sphenoidale meningioma (2009)

Haemangioblastomas are rarely seen in the suprasellar region, arising from the optic apparatus or pituitary stalk, mimicking meningiomas on the preoperative MRI scan. They may be suspected in the presence of large flow voids and the absence of a dural tail. Intraoperatively, the extreme vascularity and compressibility of the tumour with no dural attachment should alert the surgeon to the diagnosis. A complete resection with preservation of vision may be successfully attempted because of the well-demarcated tumour-nerve interface.
ChemInform Abstract: Synthesis of Prostaglandins. Part 3. Efficient and Practical Synthesis of Antisecretory Prostaglandin Enprostil. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An in-depth Monte Carlo study of lateral electron disequilibrium for small fields in ultra-low density lung: implications for modern radiation therapy (2012)

Modern radiation therapy techniques such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) use tightly conformed megavoltage x-ray fields to irradiate a tumour within lung tissue. For these conditions, lateral electron disequilibrium (LED) may occur, which systematically perturbs the dose distribution within tumour and nearby lung tissues. The goal of this work is to determine the combination of beam and lung density parameters that cause significant LED within and near the tumour. The Monte Carlo code DOSXYZnrc (National Research Council of Canada, Ottawa, ON) was used to simulate four 20 × 20 × 25 cm(3) water-lung-water slab phantoms, which contained lung tissue only, or one of three different centrally located small tumours (sizes: 1 × 1 × 1, 3 × 3 × 3, 5 × 5 × 5 cm(3)). Dose calculations were performed using combinations of six beam energies (Co-60 up to 18 MV), five field sizes (1 × 1 cm(2) up to 15 × 15 cm(2)), and 12 lung densities (0.001 g cm(-3) up to 1 g cm(-3)) for a total of 1440 simulations. We developed the relative depth-dose factor (RDDF), which can be used to characterize the extent of LED (RDDF <1.0). For RDDF <0.7 severe LED occurred, and both lung and tumour dose were drastically reduced. For example, a 6 MV (3 × 3 cm(2)) field was used to irradiate a 1 cm(3) tumour embedded in lung with ultra-low density of 0.001 g cm(-3) (RDDF = 0.2). Dose in up-stream lung and tumour centre were reduced by as much as 80% with respect to the water density calculation. These reductions were worse for smaller tumours irradiated with high energy beams, small field sizes, and low lung density. In conclusion, SBRT trials based on dose calculations in homogeneous tissue are misleading as they do not reflect the actual dosimetric effects due to LED. Future clinical trials should only use dose calculation engines that can account for electron scatter, with special attention given to patients with low lung density (i.e. emphysema). In cases where tissue inhomogeneity corrections are applied, the nature of the correction used may be inadequate in predicting the correct level of LED. In either case, the dose to the tumour is not the prescribed dose and clinical response data are uncertain. The new information from this study can be used by radiation oncologists who wish to perform advanced radiation therapy techniques while avoiding the deleterious predictable dosimetric effects of LED.
Numerical Models of Broad-Bandwidth Nanosecond Optical Parametric Oscillators (1998)

We present three new methods for modeling broad-bandwidth, nanosecond optitcal parametric oscillators in the plane-wave approximation. Each accounts for the group-velocity differences that determine the operating linewidth of unseeded optical parametric oscillators, and each allows the signal and idler waves to develop from quantum noise. The first two methods are based on split-step integration methods in which nonlinear mixing and propagation are calculated separately on alternate steps. One method relies on Fourier transforming handle propagation, wiih mixing integrated over a the fields between t and u to Az step: the other transforms between z and k= in the propagation step, with mixing integrated over At. The third method is based on expansion of the three optical fields in terms of their respective longitudinal empty cavity modes, taking into account the cavity boundary condi- tions. Equations describing the time development of the mode amplitudes are solved to yield the time dependence of the three output fields. These plane-wave models exclude diffractive effects, but can be readily extended to include them.