gebhart/patrepeval huggingface dataset:
Some Characteristic Properties of Hemoglobin C (1955)

Abstract 1. The present paper describes an apparently white family in which a few members suffered from homozygous and heterozygous hemoglobin C disease. Since the paternal great grandfather and the maternal grandfather of the patients examined were in a family relation of the first order, it is surmised that the hemoglobin C was derived from the same homozygous negroid (?) ancestor. Besides its occurrence in this family Hb-C is also found in a colored family from the same island (Curaçao). 2. Hemoglobin C shows, in addition to abnormal electrophoretic mobility, three other more or less specific properties: a. During chromatographic examination carried out with the aid of the cation exchanger Amberlite IRC 50 (XE 64), a citrate citric acid buffer at pH 6 and sodium ion concentration of 0.15, COHb-C displaces itself noticeably slower than the three other forms of hemoglobins (S, A and F). b. The solubility of the COHb-C in a phosphate buffer pH 6.5 of various concentrations is significantly less than that of COHb-S, COHb-A and COHb-F. The reduced form of hemoglobin C does not show this property; the solubility of this is practically the same as that of reduced adult hemoglobin. c. A comparison of the amino acid composition of hemoglobin C and hemoglobin A, S and F, shows that COHb-C contains a higher number of lysine and perhaps histidine residues. This increase amounts to four residues per mol. for lysine and one residue per mol. for histidine. The possible connection between the more basic character of the proteins and the abnormal behavior in the electrophoretic and chromatographic experiments is discussed. 3. The results obtained with five experimental methods (electrophoresis, alkali denaturation, chromatography, salting-out experiments, and amino acid composition determination) all seem to indicate that in the homozygous form of this disease only the abnormal Hb-C is present. None of the other three hemoglobins (A, S and F) were shown to be present in determinable amounts. 4. In addition to the electrophoretic abnormalities, the above three properties may be of importance in the characterization of this abnormal hemoglobin.
Biodegradation of the Hexahydro-1,3,5-Trinitro-1,3,5-Triazine Ring Cleavage Product 4-Nitro-2,4-Diazabutanal by <i>Phanerochaete chrysosporium</i> (2004)

Initial denitration of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by Rhodococcus sp. strain DN22 produces CO2 and the dead-end product 4-nitro-2,4-diazabutanal (NDAB), OHCNHCH2NHNO2, in high yield. Here we describe experiments to determine the biodegradability of NDAB in liquid culture and soils containing Phanerochaete chrysosporium. A soil sample taken from an ammunition plant contained RDX (342 micromol kg(-1)), HMX (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine; 3,057 micromol kg(-1)), MNX (hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine; 155 micromol kg(-1)), and traces of NDAB (3.8 micromol kg(-1)). The detection of the last in real soil provided the first experimental evidence for the occurrence of natural attenuation that involved ring cleavage of RDX. When we incubated the soil with strain DN22, both RDX and MNX (but not HMX) degraded and produced NDAB (388 +/- 22 micromol kg(-1)) in 5 days. Subsequent incubation of the soil with the fungus led to the removal of NDAB, with the liberation of nitrous oxide (N2O). In cultures with the fungus alone NDAB degraded to give a stoichiometric amount of N2O. To determine C stoichiometry, we first generated [14C]NDAB in situ by incubating [14C]RDX with strain DN22, followed by incubation with the fungus. The production of 14CO2 increased from 30 (DN22 only) to 76% (fungus). Experiments with pure enzymes revealed that manganese-dependent peroxidase rather than lignin peroxidase was responsible for NDAB degradation. The detection of NDAB in contaminated soil and its effective mineralization by the fungus P. chrysosporium may constitute the basis for the development of bioremediation technologies.
HIV-1 infection and circulating peripheral blood B cell subpopulations (2014)

Results In HIV infected adults, a significant reduction in nonswitched memory B cells (CD19+IgD+CD27+) was observed, compared to healthy controls (p=0.046). With ongoing viral replication and reduced CD4 count, an expansion in CD21CD27 (tissue like memory) population was observed and the correlation was statistically significant (p=0.0004). The mean frequency of CD21CD27 (resting memory) was significantly higher in controls (p=0.0002) compared to HIV-1 infected adults, while tissue like memory were highly expanded in HIV infected adults compared to controls (p=0.0001). B cells in HIV-1 infected adults expressed higher frequency of CD95 compared to healthy controls (p=0.0004).
Multi-layered phantoms mimicking skin pathologies for high-resolution ultrasound (2020)

Quickly developed medical market of high-resolution skin imaging requires suitable phantoms simulating characteristics of skin pathologies to develop new ultrasonic imaging systems and image processing algorithms. The phantom should mimic important acoustic properties of skin to provide a realistic and responsive environment. The most significant ultrasonic parameters here are sound speed, attenuation, and backscattering. The purpose of this study was to develop multilayered phantoms imitating mechanical and acoustic properties of healthy skin, benign nevus, and melanoma lesions that can be used for high-frequency ultrasound (50MHz). Phantoms were fabricated and tested using scanning acoustic microscopes (Honda 50-SI, Tessonics AM) and hand-held skin imager. Physical and acoustic properties of the phantom materials can be controlled by varying the material composition. Evaluated acoustic parameters were found to be close to values of human skin. The phantoms can be used for an extended period (6 months) without altering its properties.
Contralateral Repeated Bout Effect of the Knee Flexors (2017)

These results showed that CL-RBE was evident for KF in a similar manner to that for EF, but did not last for 28 d, and the CL-RBE was smaller than the ipsilateral RBE.
Active Sites for the Reaction of Ethanol to Acetaldehyde on Co/YSZ(100) Model Steam Reforming Catalysts (2011)

Structure–activity relationships for the reaction of ethanol on model Co/YSZ(100) (YSZ = yttria-stabilized ZrO2) steam reforming catalysts were investigated using temperature-programmed desorption (TPD) and X-ray photoelectron spectroscopy and compared with those obtained previously for the reaction of ethanol on Co/ZnO(0001) and Co foils. Oxygen-free, metallic Co sites were found to be active for ethanol decarbonylation to form CO, H2, and adsorbed CH3 groups, whereas oxygen adatoms on metallic Co promoted ethoxide dehydrogenation to produce acetaldehyde at 330 K during TPD. In contrast, oxidized Co surfaces containing only Co2+ sites were found to be less reactive for ethanol dehydrogenation producing acetaldehyde at 480 K. These results, along with comparisons with those from Co/ZnO(0001) and Co foils, provide new insights into the active sites for ethanol steam reforming on Co-based catalysts and the influence of the support on both catalyst reactivity and stability.
Interpreting Substituent Effects on the Crystal Packing of Long-Chain Diacyl Peroxides. The Crystal Structures of D1 (11 Bromoundecanoyl) Peroxide and Di (Undecanoyl) Peroxide (1988)

Abstract Although crystals of di(11-bromoundecanoyl) peroxide and di(undecanoyl) peroxide have different space groups (P43212 and C2221), the molecules pack in almost identical layers. They differ only in the nature of stacking across interfaces involving the terminal groups. Because the 90° twist about the O-O bond locks neighboring molecules together within the layer, each peroxide shows a single solid phase from 5K to the melting point. Analysis of the stacking pattern in terms of the six possible orientational relationships suggests special stability for an L-shaped motif of C-Br-Br-C. Other substituents create different stackings of the same layer structure to give three crystal classes and five space groups among 14 compounds. Unsymmetrical peroxides are useful both for forcing a variety of substituted chains (particularly odd-even homologues) to pack with identical layer structures, and for controlling the stacking pattern. Because structural differences are localized in the vicinity of the substituents, this series of “substitutional polytypes” will allow systematic investigation of substituent effects on the physical and chemical properties of solids.
Comparative effects of "defective" genotypes in NPV populations: their roles in SfMNPV vs SeMNPV (2010)

Trabajo presentado en la 43rd Annual Meeting of the Society for Invertebrate Pathology y 10th International Colloquium on Invertebrate Pathology, celebrado en Trabzon (Turquía) del 11 al 15 de julio de 2010. The Final Meeting of COST862 Action: Bacterial Toxins for Insect Control.
Growth of (Ge,Mn) nanocolumns on GaAs(100): the role of morphology and co-doping on magnetotransport (2009)

Changing the morphology of the growing surface and the nature of residual impurities in (Ge,Mn) layers - by using different substrates - dramatically changes the morphology of the ferromagnetic Mn-rich inclusions and the magnetotransport properties. We obtained p-type layers with nanocolumns, either parallel or entangled, and n-type layers with spherical clusters. Holes exhibit an anomalous Hall effect, and electrons exhibit a tunneling magnetoresistance, both with a clear dependence on the magnetization of the Mn-rich inclusions; holes exhibit orbital MR, and electrons show only the normal Hall effect, and an additional component of magnetoresistance due to weak localization, all three being independent of the magnetic state of the Mn rich inclusions. Identified mechanisms point to the position of the Fermi level of the Mn-rich material with respect to the valence band of germanium as a crucial parameter in such hybrid layers.
ChemInform Abstract: Researcch on Heterocyclic Compounds. Part 30. Synthesis and Pharmacological Activity of 2‐Methylimidazo(1,2‐b)pyridazine‐3‐ carboxylic Acids. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On spectrum placement for linear time invariant delay systems (1982)

A ring of delay operators is used to obtain a ring model description of a linear time invariant delay system. With this aid an algorithm is developed for the computation of the polynomial state-feedback matrix which assigns an arbitrary set of poles of the closed-loop system (spectrum placement). An example is included to illustrate the method.
Electromagnetic time-reversal imaging of a target in a cluttered environment (2005)

Electromagnetic time-reversal imaging is addressed for a target situated in a cluttered background. We first investigate the theory of electromagnetic time-reversal imaging, followed by an experimental demonstration. A transmitter-receiver antenna array is connected to a network analyzer and applied to transmit wideband waveforms for detecting a target within a cluttered environment. We assume the cluttered background is fixed, thus the target signature is extracted by observing changes manifested by the introduction of a target. A numerical algorithm is required for computation of the Green's function employed within the time-reversal imager, with this implemented here via ray tracing. Example time-reversal images of different cluttered backgrounds and different targets are presented using measured data, with comparisons to a traditional radar imaging technique. Results show that the time-reversal imagery yields good focusing at the target, significantly better than when the background is not accounted for.
Benefits of Danazol Treatment in Patients With Hemophilia A (Classic Hemophilia) (1985)

Danazol, an attenuated androgen, was given intermittently in three patients with hemophilia A. The rise in factor VIII activity with danazol treatment was associated with a fivefold decrease in hemorrhagic episodes and plasma concentrate product utilization when compared with similar periods without the drug. Four other patients with moderate hemophilia A who received danazol for 14 days had an increase of 400% to 850% in their factor VIII levels. Of four patients without detectable levels of factor VIII who were treated with danazol, two had elevations of the factor VIII level, to 3% and 4%, respectively. Danazol appears to be an effective treatment for patients with hemophilia A.
An application of Severi’s theory of a basis to the Kummer and Weddle surfaces (1914)

In a series of papers F. Severif has developed a theory by means of which any linear system of algebraic curves on an algebraic surface can be expressed linearly in terms of a finite number of such systems. He has also applied this theory to the study of the curves on the Fano quartic surface and to the determination of the group of birational transformations which leave this surface invariant.
Influence of Cold-Working on Damping Characteristics of Al-Zn Alloys (1982)

Effect of cold-working on the damping of furnace-cooled or water-quenched Al-Zn alloys with 0-100%Zn was studied by varying the reduction in area. Measurements of the logarithmic decrement δ and the regidity modulus G were carried out by the inverted pendulum method at a frequency of 1 Hz. The hardness Hv was measured using a micro-Vickers hardness tester, and the specific weight S by the Archimedean method.Except for the water-quenched alloys with 70-90%Zn, the heat-treated alloys have generally a low δ. The order of magnitude of δ in the alloys subjected to heat-treatments depends on the viscous flow at the grain boundary between α and β phases. Upon cold-working, the δ becomes considerably larger with increasing reduction in area. The increase in δ is due to the increasing boundary effect resulting from the refinement of grains and to the increasing viscous and hysteretic motions of dislocations.Hv values of the alloys with 10-70%Zn water-quenched from 673 K are considerably higher than those for furnace-cooling. On the other hand, the alloys with 80-90%Zn furnace-cooled show Hv values higher than those water-quenched. The nearer the eutectoid composition, the lower becomes the Hv value after cold-working. G values of the alloys water-quenched from 573 K or furnace-cooled from 573 and 673 K increase with increasing Zn content, while those after water-quenching from 673 K show a minimum value at 50%Zn. The G upon cold-working is nearly constant up to 40%Zn and increases rapidly with Zn content in excess of 40%, regardless of the prior heat-treatment. The S increases with Zn content, but the value is generally as small as 4.8 Mg/m3 even for the Al-70%Zn alloy.
Presence of HTLV-III Antibodies in Immune Serum Globulin Preparations (1987)

The authors tested 15 immune serum globulin pharmaceutical preparations for antibody reactivity to human T cell lymphotrophic virus type III (HTLV-III) by the Abbott immunoenzymometric assay (IEMA). Although no evidence of HTLV-III infectivity has appeared after injection of similar preparations into humans, the authors found all samples IEMA reactive. Upon dilution, the authors demonstrated parallel decreases of antibody reactivity among two samples of gamma globulin, the Abbott-positive control, and a markedly reactive patient specimen. Gamma globulin isolated from sera of six animal species was nonreactive in the Abbott assay. All samples were nonreactive with the H-9 cell line antigen. Antibody reactivity to HTLV-III was confirmed in 13 of 15 gamma globulin samples when tested by the Electro-Nucleonics IEMA, and 14 samples contained at least the p24 band on Western blot analysis. Although false positivity occurs in IEMA assays possibly because of elevated protein concentrations and nonspecific binding, the authors, results show that in most circumstances immune serum globulin preparations tested do contain true reactivity to HTLV-III.
A Fully Integrated 65 nm CMOS cascode HSFDS PA Dedicated to 802.11n Application (2010)

International audience
ChemInform Abstract: New Synthetic Route to Polyhedral Organylsilsesquioxanes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dynamic scaling of the submonolayer island size distribution during self-assembled monolayer growth (1999)

In situ atomic force microscope observations of the formation of octadecylphosphonic acid monolayers, deposited from solution onto mica, indicate that growth proceeds via the nucleation, growth, and coalescence of densely packed submonolayer islands of adsorbate molecules. Three regimes are observed: (1) an initial growth regime where nucleation of new islands is significant, (2) an aggregation regime where nucleation essentially stops and existing islands grow, and (3) a coalescence regime where individual islands merge, resulting in fewer islands. In analogy with vapor phase thin-film deposition (such as molecular-beam epitaxy) the island size distribution in the aggregation regime is predicted to show dynamic scaling behavior, indicating that at a given time, only one length scale is present. We explicitly verify this dynamic scaling assumption, showing that the island size distributions, over a range of surface coverage from 0.06--0.17, can be collapsed into a single dimensionless distribution function by the theoretically predicted scaling relationships. The shape of this distribution function implies that Ostwald ripening is not a significant factor and that the critical nucleus is \ensuremath{\leqslant}2 molecules.
A General Route to 1,3′-Bipyrroles (2013)

A general method is described for the synthesis of 1,3'-bipyrroles. The route involves constructing a pyrrole ring on the nitrogen of a substituted 1H-pyrrole, so as to generate the 1,3'-bipyrrole. In this approach the nitrogen of the starting pyrrole was alkylated with a special Michael acceptor having an allylic leaving group, and the product was then modified in such a way that the second pyrrole ring could be formed by a Paal-Knorr reaction. Two variants of this sequence were examined, one of which led to formation of a 3-hydroxypyridine instead of the second pyrrole ring; the other variant used phenacyl bromide instead of the special Michael acceptor.
Microsurgical approach to the abdominal thoracic duct in the rat: Considerations in the collection of lymphocytes (1992)

In experiments involving the collection of thoracic duct lymphocytes the anatomy of the abdominal thoracic duct in the rat has been further defined. In general, the abdominal thoracic duct lies posterior and to the left of the aorta between the renal arteries and the diaphragm. There are variations in the microsurgical approach to the classically described location of this organ that should be noted by investigators attempting to identify and dissect this structure.
Partial rescue of mucopolysaccharidosis type <scp>VII</scp> mice with a lifelong engraftment of allogeneic stem cells <i>in utero</i> (2014)

Abstract In utero hematopoietic cell transplantation ( IUHCT ) has been performed in Mucopolysaccharidosis Type VII ( MPSVII ) mice, but a lifelong engraftment of allogeneic donor cells has not been achieved. In this study, we sought to confirm a lifelong engraftment of allogeneic donor cells immunologically matched to the mother and to achieve partial rescue of phenotypes in the original MPSVII strain through IUHCT by intravenous injection. We performed in vitro fertilization in a MPSVII murine model and transferred affected embryos to ICR /B6‐ GFP surrogate mothers in cases where fetuses receiving IUHCT were all homozygous. Lineage‐depleted cells from ICR / B6 ‐ GFP mice were injected intravenously at E 14.5. Chimerism was confirmed by flow cytometry at 4 weeks after birth, and β‐glucuronidase activity in serum and several phenotypes were assessed at 8 weeks of age or later. Donor cells in chimeric mice from ICR / B6 ‐ GFP mothers were detected at death, and were confirmed in several tissues including the brains of sacrificed chimeric mice. Although the serum enzyme activity of chimeric mice was extremely low, the engraftment rate of donor cells correlated with enzyme activity. Furthermore, improvement of bone structure and rescue of reproductive ability were confirmed in our limited preclinical study. We confirmed the lifelong engraftment of donor cells in an original immunocompetent MPSVII murine model using intravenous IUHCT with cells immunologically matched to the mother without myeloablation, and the improvement of several phenotypes.
Phenolic constituents and biological activities of leaf extracts of traditional medicinal plant Plectranthus amboinicus Benth (Lamiaceae) (2013)

Plectranthus amboinicus Benth (Lamiaceae) is a medicinal plant native to India, and its leaves are widely used in several traditional medicinal preparations. The purpose of this study was to detect and quantify phenolics present in ethyl acetate and acetone extracts of P. amboinicus leaves, and evaluate their antioxidant, antibacterial, antimutagenic and anticancer activities. The HPLC chromatograms of crude leaf extracts indicated the presence of phenolics like caffeic acid, coumaric acid, rutin, quercetin and gallic acid, which were present in the range of 0.01 - 1.41 mg/g in ethyl acetate and 0.03 - 1.93 mg/g in the acetone extract. The acetone extract showed statistically (p < 0.05) higher antioxidant activity (<TEX>$IC_{50}$</TEX>, 99.59 <TEX>${\mu}g/ml$</TEX>) than ethyl acetate extract (<TEX>$IC_{50}$</TEX>, 149.96 <TEX>${\mu}g/ml$</TEX>). Statistically (p < 0.05) higher antimutagenicity was shown by acetone extract (46.16%) as compare to ethyl acetate extract (12.16%) at 500 <TEX>${\mu}g/plate$</TEX> concentration. The acetone extract showed higher antibacterial activity than ethyl acetate extract, and both the extracts showed highest activity against B. cereus (375 and 625 <TEX>${\mu}g/ml$</TEX>, respectively) and lowest activity against Y. enterocolitica (1000 and 1125 <TEX>${\mu}g/ml$</TEX>, respectively). Both the extracts also showed inhibitory effect on cancer cell lines HCT-15 and MCF-7. These results suggest that the leaves of P. amboinicus possess various biological activities, and validate the traditional use of the leaves of P. amboinicus against cold, infection and ulceration.