gebhart/patrepeval huggingface dataset:
Equipment for linking the AutoAnalyzer on-line to a computer (1971)

An Elliott 903 computer with 8K central core store and magnetic tape backing store has been operated for approximately 20 months in a clinical chemistry laboratory. Details of the equipment designed for linking AutoAnalyzers on-line to the computer are described, and data presented concerning the time required by the computer for different processes. The reliability of the various components in daily operation is discussed. Limitations in the system's capabilities have been defined, and ways of overcoming these are delineated. At present, routine operations include the preparation of worksheets for a limited range of tests (five channels), monitoring of up to 11 AutoAnalyzer channels at a time on a seven-day week basis (with process control and automatic calculation of results), and the provision of quality control data. Cumulative reports can be printed out on those analyses for which computer-prepared worksheets are provided but the system will require extension before these can be issued sufficiently rapidly for routine use.
Antiphytoviral Activity of Satureja montana L. ssp. variegata (Host) P. W. Ball Essential Oil and Phenol Compounds on CMV and TMV (2010)

The essential oil of Satureja montana L. ssp. variegata (Host) P. W. Ball (Lamiaceae) was characterized by a high concentration of oxygenated monoterpenes (71.3%), among which carvacrol (19.4%) and thymol (16.6%) were the major compounds. When the essential oil was applied on local hosts Chenopodium amaranticolor Coste & Reyn. and Chenopodium quinoa Willd. simultaneously with the infecting virus, the number of local lesions on both Tobacco mosaic virus (TMV) and Cucumber mosaic virus (CMV) infected plants was reduced for 29.2% and 24.1%, respectively. When applied individually for each virus, thymol was more effective in reducing CMV infection (33.2%), while carvacrol was more effective in reducing the TMV infection (34.3%). No synergistic effect of both monoterpenes was observed in the antiviral activity of the oil.
Generation and characterization of transgenic mice (Tg-hPAR1) expressing human PAR1 transgene under control of human α<sub>IIb</sub> promoter. (2015)

<p>(<b>A</b>) Schematic representation of the transgene construct. The cDNA for human PAR1 was inserted into a vector containing the human α<sub>IIb</sub> promoter, a small-t intron of simian virus 40 (SV40), and a Kozak sequence at the 5′-untranslated region (UTR) and SV40 polyadenylation (polyA) sequence at the 3′ -UTR. (<b>B</b>) Representative genotyping from α<sub>IIb</sub>-Tg-hPAR1. (<b>C</b>) Expression of hPAR1 was measured on the surface of platelets from human, wild type mice (wt, black line) and transgenic mice (α<sub>IIb</sub>-Tg-hPAR1) using anti-PAR1-PE (WEDE15, red line) or IgG-PE (gray line) and analyzed by flow cytometry. (<b>D</b> and <b>E</b>) Intracellular calcium mobilization was measured in platelets from wild type (wt) (gray line) and α<sub>IIb</sub>-Tg-hPAR1 (black line) mice in response to thrombin (1 nM) (<b>D</b>) or SFLLRN (100 µM) (<b>E</b>). The calcium tracings are representative of three independent experiments.</p>
The Effect of the Platelet Count on the Aggregation Response and Adenosine Triphosphate Release in an Impedance Lumi-Aggregometer (1988)

Platelet aggregation studies are usually performed in either electrical impedance or optical systems and the release reaction assessed by quantitating adenosine triphosphate (ATP) from luminesence produced by the firefly luciferin-luciferase system. In evaluating the results of such studies, attention is paid to a variety of parameters such as the slope of the aggregation response and the maximum aggregation expressed as percent light transmission in optical and as Ohms in electrical impedance systems. Although threshold platelet counts are frequently cited below which the performance of these studies is technically difficult, the influence of the platelet count within the normal range on the results of such studies has not been prospectively addressed. This study examines the relationship between the aggregation response, ATP release and the platelet count in a lumi-impedance system. It is clear that the platelet count influences the results in this system and requires consideration in the interpretation if an erroneous conclusion is to be avoided.
D<scp>ental</scp> C<scp>aries</scp> V<scp>accines:</scp> P<scp>rospects and</scp> C<scp>oncerns</scp> (2002)

Dental caries remains one of the most common infectious diseases of mankind. Cariogenic micro-organisms enter the dental biofilm early in life and can subsequently emerge, under favorable environmental conditions, to cause disease. In oral fluids, adaptive host defenses aroused by these infections are expressed in the saliva and gingival crevicular fluid. This review will focus on methods by which mucosal host defenses can be induced by immunization to interfere with dental caries caused by mutans streptococci. The natural history of mutans streptococcal colonization is described in the context of the ontogeny of mucosal immunity to these and other indigenous oral streptococci. Molecular targets for dental caries vaccines are explored for their effectiveness in intact protein and subunit (synthetic peptide, recombinant and conjugate) vaccines in pre-clinical studies. Recent progress in the development of mucosal adjuvants and viable and non-viable delivery systems for dental caries vaccines is described. Finally, the results of clinical trials are reviewed, followed by a discussion of the prospects and concerns of human application of the principles presented.
Synthesis of Low-Generation, Aryl-/Alkyl-Type, Nonpolar Dendrons Carrying Protected Hydroxyalkyl Groups in the Periphery (2002)

An efficient convergent synthesis of first- and second-generation aryl-/alkyl-type nonpolar dendrons via Suzuki cross-coupling is described. The dendrons carry either one or two benzyl-protected hydroxyalkyl groups/terminus. Iododesilylation reactions of aryltrimethylsilanes with iodo chloride are used as a tool for the incorporation of iodo, an important functionality for transition-metal-catalyzed cross-coupling reactions. In the case of sensitive aromatics, the addition of some donor solvent like diethyl ether proved effective in suppressing side reactions through electrophilic aromatic iodination.
Pd-Catalyzed Asymmetric Hydrogenation of C=C Bond of α,β-Unsaturated Ketones (2011)

Homogenous palladium-catalyzed asymmetric hydrogenation of C=C double bond of alpha,beta-unsaturated ketones has been developed by using palladium(II) trifluoroacetate/(S)-7,7'-bis[ di(4-methoxyphenyl]phosphino)-1,1'-spirobiindane complex [Pd(OCOCF(3))(2)-(S)-An-SDP] as the catalyst under ambient hydrogen pressure and room temperature with up to 89% ee.
Effect of sulfur supplements on cellulolytic rumen micro-organisms and microbial protein synthesis in cattle fed a high fibre diet (2007)

Through the use of real-time PCR monitoring, a better understanding of the effect of S supplementation on discrete microbial populations within the rumen is provided.
LONG-TERM FOLLOW-UP OF A RANDOMIZED TRIAL COMPARING T CELL DEPLETION WITH A COMBINATION OF METHOTREXATE AND CYCLOSPORINE IN ADULT LEUKEMIC MARROW TRANSPLANT RECIPIENTS (1994)

Forty-eight adult leukemic recipients of HLA-identical sibling marrow were randomized to T cell depletion using anti-CD8 and anti-CD6 antibodies plus complement (n = 28) or prophylaxis with methotrexate (MTX) and cyclosporine (CsA) (n = 25). Patient characteristics were comparable in the two groups. The median observation time was 5 1/2 years. Transfusions, infections, and acute GVHD did not differ between the groups. Chronic GVHD occurred in 52% of patients receiving T cell-depleted marrow and 23% of those receiving MTX + CsA (P = 0.06). Overall probability of relapse was similar in both groups and actuarial leukemia-free survivals at 5 years were 39% and 35% in the two groups, respectively. Among patients with chronic myeloid leukemia (CML), leukemia-free survival at 5 years was 25% in patients receiving T cell-depleted marrow compared with 51% in those given MTX + CsA (P = 0.09). In patients with acute leukemia the probability of relapse was 24% in the group receiving T cell-depleted marrow compared with 73% in those treated with MTX + CsA (P = 0.06). Leukemia-free survival was 55% and 21% in the two groups, respectively (NS). CML patients tended to have a poorer prognosis and those with acute-leukemia better outcome with T cell depletion than with combined MTX + CsA. It is concluded that T cell depletion is unsuitable for patients with CML, but may be considered in patients with acute leukemia.
Distributed locking: a mechanism for constructing highly available objects (2003)

A description is given of the results of a study of methods of achieving fault tolerance in the Clouds system and, in particular, of achieving increased availability of objects. The problems explored in this work, the model of distributed computation in which the problems posed by the research were examined (the Clouds system), the tools that were used to address these problems (the Aeolus programming language), and some related research are briefly described. The authors present a methodology for achieving available services by conversion of resilient single-site implementations into replicated implementations. A mechanism with which they propose to support this methodology, called distributed locking (DL), is presented. A description is also given of a linguistic feature for the specification of the availability properties of an object replicated via DL. The language runtime support features (primitives) required for DL and the operating system support needed for these features are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Study and optimization of an optical see-through near to eye display system for augmented reality (2018)

La these porte sur un nouveau concept pour les afficheurs de realite augmentee places pres de l’œil, notamment pour ameliorer les champs de vision. Deux guides d'ondes sont empiles avec un petit espace d'air entre eux. La lumiere couplee dans le premier guide d'ondes par le coupleur d’entree se propage par reflexion interne totale jusqu'a atteindre un miroir cylindrique a l'extremite du guide. Puis, la lumiere reflechie est couplee dans le second guide d'ondes avant d'atteindre le coupleur de sortie. Un systeme similaire base sur des micro-prismes est aussi decrit. Les conceptions ont ete simulees avec le logiciel Zemax. Les champs de vision horizontal et vertical obtenus sont respectivement de 30° et 60°. La Fonction de Transfert de Modulation pour tous les champs objets est superieure a 30% pour 33 npl/mm, ce qui est suffisant pour un systeme visuel. De plus, un grand volume de deplacement admissible pour l’œil (Eye-box) d'environ 10×8 mm a ete obtenu.
Low-delay analysis-by-synthesis speech coding using lattice predictors (2002)

Results on low-delay vector excitation coding (LD-VXC) obtained by using adaptive lattice filters for implementing the short-term predictor and the perceptual weighting filter are discussed. The new codec, the lattice LD-VXC (LLD-VXC), is based on a backward adaptive analysis-by-synthesis configuration in which a least-mean-square (LMS) recursive algorithm is used for updating the lattice filters. The shape-only codebook and the gain-shape codebook are compared as possible candidates for the excitation codebook. The performance of the LLD-VXC codec versus the short-term predictor order is studied. It is shown that the performance increases for short-term predictor orders of up to 20-30 and then saturates. A LLD-VXC codec with a pitch predictor and a short-term predictor or order 20 achieves the same speech quality as a system without a pitch predictor and with a short-term predictor of order 50, and the LLD-VXC codec offers toll speech quality at 16 kb/s with moderate complexity and a total communications delay of under 2 ms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Long‐Term Structural and Chemical Stability of DNA in Hydrated Ionic Liquids (2010)

Storage solutions: DNA is shown to be soluble in a variety of choline-based, hydrated ionic liquids (ILs; see picture). The IL-stored DNA molecules have exceptional long-term stability, in excess of one year.
Cytokine response of T-cell subsets from Brucella abortus-infected mice to soluble Brucella proteins (1993)

Hot saline extracts of Brucella abortus 19 were separated by successive differential precipitation with 50 and 70% ammonium sulfate, yielding fractions SBP50, with predominantly 36-kDa proteins and a number of medium-sized proteins (26 to 33 kDa), and SBP70, with 14-kDa and lower-molecular-mass proteins. Both fractions stimulated specifically proliferation and cytokine production by spleen cells from brucella-infected mice, although the activity of SBP50 was much higher than that of SBP70. Further separation of SBP50 by a DEAE-Sepharose column resulted in three distinct subfractions which were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The three subfractions were analyzed for their abilities to induce lymphocytes to proliferate and produce cytokines. The three subfractions were all active but with characteristic differences in magnitude. Subfraction 1 stimulated moderate proliferation, high interleukin 6 (IL-6) production, and relatively low production of gamma interferon (IFN-gamma). Subfraction 2 was the strongest stimulus for proliferation and production of IL-6 and IFN-gamma, while subfraction 3 stimulated moderate cell proliferation, a high level of IFN-gamma, and a low level of IL-6. IL-2 production stimulated by the three subfractions was similar. SBP50 and all three subfractions stimulated purified T cells of both CD4+ and CD8+ subsets to produce IFN-gamma. The production of IFN-gamma by CD8+ T cells to brucella antigens was enhanced with exogenous IL-2.
Facile Synthesis of Well‐Dispersed Silver Nanoparticles on Hierarchical Flower‐like Ni<sub>3</sub>Si<sub>2</sub>O<sub>5</sub>(OH)<sub>4</sub> with a High Catalytic Activity towards 4‐Nitrophenol Reduction (2012)

Layered nickel silicate nanoflowers (NSFs) with a hierarchical nanostructure have been successfully fabricated by a template-free solvothermal method. The as-prepared nanoflowers were composed of many interconnected edge-curving lamellae with a thickness of about 15 nm and had a high specific surface area (279 m(2) g(-1)) and large pore volume (0.67 cm(3) g(-1)). The highly dispersed small silver nanoparticles (AgNPs) were immobilized on the surface of NSFs through the in situ reduction of Ag(+) by Sn(2+). The AgNP/NSF nanocomposites showed a high performance in the catalytic reduction of 4-nitrophenol. In particular, there was no visible decrease in the catalytic activity of the reused catalysts even after being recycled four times. The as-prepared AgNP/NSF nanocomposites might be an excellent catalyst owing to their availability, formability, chemical and thermal stability, and high specific surface area.
Synthesis of Er<sup>3+</sup>-doped silicon-based light emitting material by sol-gel method (2000)

We suggested a new synthesis process, the sol-gel method, to incorporate high concentration of Er<SUP>3+</SUP> ions into the silicate film on silicon substrate. The coating solutions with uniformly dispersed metal ions were prepared from Er(NO)<SUB>3</SUB> solution, Si(OC<SUB>2</SUB>H<SUB>5</SUB>)<SUB>4</SUB> and ethanol. Spin coating was carried out into a treated mono-crystalline silicon (100) substrate, at a speed of about 4000-rpm for 8s. The precursor films were annealed in air at 500 degree(s)C for 2 hours. Er-related approximately 1.54 micrometers photoluminescence was observed at room temperature. The optimal doped concentrations of Er<SUP>3+</SUP> in SiO<SUB>2</SUB> film was estimated at about approximately 10<SUP>21</SUP>/cm<SUP>3</SUP>. Through characterizations of AFM, FTIR, DTA, TG and EXAFS, we found that: the synthesized film is compact and smooth in microscope; 500 degree(s)C annealing is enough to perform the structure change of gel to glass; and, the Er-O formed complex with coordinate number of 9. Because of the formation of Er-O complex, Er-O-Si can form the next structure in the synthesized film. The configuration could not only increase the optical activity of ions, but also improve the homogeneous of Er<SUP>3+</SUP> ions in SiO<SUB>2</SUB>. Thus we demonstrated the sol-gel process is an efficient way to overcome the quench effect of concentration and increase the distribution quality.
Female hydrocele of the canal of Nuck: a case report. (2011)

This is a case report of a congenital right labia majora hydrocele in a 13-year-old adolescent girl. Hydrocele of the canal of Nuck is a rare condition in females. A small invagination of the parietal peritoneum that fails to obliterate during the first year of life, can result in either an indirect hernia or a hydrocele of the canal of Nuck.
Novel algorithm for Bayesian network parameter learning with informative prior constraints (2010)

The generalization performance of a learned Bayesian network largely depends on the quality of the prior provided to the learning machine. Indeed, the prior distribution is designed to provide additive domain expert knowledge to the parameters in a Bayesian network which tolerate some variance around these initial counts. The learning task is combinatorial regulates on this initial counts by the data statistics. The use of a prior distribution becomes even more critical in case of scarce data. One essential problem in specifying Dirichlet prior (commonly used in maximum-a-posterior estimation) is that, it is often impossible for a domain expert to accurately specify the parameters of a Dirichlet distribution since they are unintuitive to a domain expert. Consequently, in practice, the parameters of a Dirichlet prior are either randomly assigned or set equally which results either non-informative prior or statistically inaccurate prior. When data is scarce, this inaccurate prior induce additive bias in selecting the single best model. On the other hand, there is usually qualitative information available from many resources in a domain, such as domain expert, literature, database etc. These knowledge usually contains validated information describing certain qualitative relations, e.g. inequality or logic, among entities in the domain. This type of qualitative knowledge have been ignored in Bayesian network learning due to their properties of lacking quantitative information which is desired to a learning machine. In this paper, we propose a novel framework for learning parameters in Bayesian networks by integrating generic qualitative domain knowledge with quantitative data. We firstly translate qualitative information into mathematic formulations, e.g. constraints. Then we recruit Monte Carlo sampling to reconstruct the quantitative prior distribution out of the qualitative domain knowledge and design a novel score to combine the prior distribution with data statistics. We test our algorithms (QMAP) both in genetic regulatory network in computational biology and in facial Action Unit recognition network in computer vision. The learning results show that i) with even very generic qualitative domain knowledge, QMAP outperforms drastically ML and MAP estimation, ii) QMAP achieve surprisingly good estimation even with very scarce data and dramatically reduced the dependence on the amount of training dataset.
THE SYNTHESIS OF FLUORANTHENE DERIVATIVES<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE SYNTHESIS OF FLUORANTHENE DERIVATIVES1C. F. H. ALLEN and J. A. VanALLANCite this: J. Org. Chem. 1952, 17, 6, 845–854Publication Date (Print):June 1, 1952Publication History Published online1 May 2002Published inissue 1 June 1952https://pubs.acs.org/doi/10.1021/jo01140a010https://doi.org/10.1021/jo01140a010research-articleACS PublicationsRequest reuse permissionsArticle Views415Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Syndrome of Generalized Resistance to Thyroid Hormone (Grth) (1989)

(1989). The Syndrome of Generalized Resistance to Thyroid Hormone (Grth) Endocrine Research: Vol. 15, No. 4, pp. 717-743.
Fabricating Super‐Hydrophobic Lotus‐Leaf‐Like Surfaces through Soft‐Lithographic Imprinting (2006)

Abstract Summary: A soft‐lithographic imprinting approach to fabricate super‐hydrophobic surfaces has been developed in this work. In this process, fresh lotus leaves were used as masters and PDMS stamps were prepared by replica molding against the lotus‐leaf surfaces. By using the stamps and an epoxy‐based azo polymer solution as “ink”, the mimicked lotus‐leaf surfaces made of the polymer were fabricated by pressing the featured faces of the stamps against “inked” substrates and drying under a proper condition after peeling off the stamps. The lotus‐leaf‐like surfaces show super‐hydrophobic characteristics with the water contact angle higher than 150° and contact angle hysteresis less than 3°. SEM images of lotus‐leaf‐like papillary structures on the imprinted surface. magnified image SEM images of lotus‐leaf‐like papillary structures on the imprinted surface.
"Predicable of" in Aristotle's Categories (1973)

69 "Predicable of" in Aristotle's Categories SHELDON MARC COHEN n their article "The One and the Many"' Gareth B. Matthews and I S. Marc Cohen explicated the notion of "said of a subject" in Aristotle's Categories thusly : ' (1) "o is said of a subject, x, if and only if, x is said to be a o (or a kind of o). (2) "That is, o is said of a subject, x, if and only if, x is classified [in an absolutely fundamental way] as a o. (3) "If x is classified as a o, then the definition of
Enveloped virus‐like particles as vaccines against pathogenic arboviruses (2015)

Arthropod-borne arboviruses form a continuous threat to human and animal health, but few arboviral vaccines are currently available. Advances in expression technology for complex, enveloped virus-like particles (eVLPs) create new opportunities to develop potent vaccines against pathogenic arboviruses. In this short review, I highlight the successes and challenges in eVLP production for members of the three major arbovirus families: Flaviviridae (e.g., dengue, West Nile, Japanese encephalitis); Bunyaviridae (e.g., Rift Valley fever); and Togaviridae (e.g., chikungunya). The results from pre-clinical testing will be discussed as well as specific constraints to the large-scale manufacture and purification of eVLPs, which are complex assemblies of membranes and viral glycoproteins. Insect cells emerge as ideal substrates for correct arboviral glycoprotein folding and posttranslational modification to yield high quality eVLPs. Furthermore, baculovirus expression in insect cell culture is scalable and has a proven safety record in industrial human and veterinary vaccine manufacturing. In conclusion, eVLPs produced in insect cells using modern biotechnology have a realistic potential to be used in novel vaccines against arboviral diseases.