gebhart/patrepeval huggingface dataset:
Nature of the Chemical Bond Formed with the Structural Metal Ion at the A9/G10.1 Motif Derived from Hammerhead Ribozymes (2004)

We have studied the interaction between metal ions and the metal ion-binding motif in hammerhead ribozymes, as well as the functions of the metal ion at the motif, with heteronuclear NMR spectroscopy. In this study, we employed model RNA systems which mimic the metal ion-binding motif and the altered motif. In Co(NH3)6(III) titrations, we observed large 1H and 31P chemical shift perturbations for the motif and found that outer-sphere complexation of Co(NH3)6(III) is possible for this motif. From the reinvestigation of our previous 15N chemical shift data for Cd(II) binding, in comparison with those of organometallic compounds, we conclude that Cd(II) can form an inner-sphere complex with the nucleobase in the motif. Therefore, the A9/G10.1 site was found to accept both inner-sphere and outer-sphere complexations. The Mg(II) titration for a slightly different motif from the A9/G10.1 site (G10.1-C11.1 to A10.1-U11.1) revealed that its affinity to Mg(II) was drastically reduced, although the ribozyme with this altered motif is known to retain enzymatic activities. This observation suggests that the metal ion at these motifs is not a catalytic center of hammerhead ribozymes.
Heart involvement and systemic sclerosis (2005)

Scleroderma heart involvement (SHI) is often manifest, and virtually always present when accurately searched and holds a significant prognostic value. Myocardial involvement by patchy fibrosis (secondary to both repeated ischaemia and immunoinflammatory damage) leads to ventricular diastolic dysfunction, whereas right ventricle overload and failure may complicate pulmonary hypertension. Left ventricular systolic dysfunction is present in a minority of patients, namely those presenting atherosclerotic coronary artery disease and/or arterial hypertension, sometimes triggered by sclerodermic renal involvement. Dysrhythmias and conduction disturbances are considered an hallmark of SHI, facilitated by autonomic dysfunction. SHI is frequently linked to parenchimal and/or vascular lung disease; they determine symptom occurrence, particularly dyspnoea, fatigue, palpitations and chest pain when pericardium is affected. Accurate cardiologic baseline screening and subsequent follow-up are mandatory in all patients, initially consisting in some noninvasive diagnostic procedures: visit, electrocardiogram (EKG), chest X-ray, Doppler-echocardiography. When needed, these examinations should be integrated by EKG Holter-monitoring, cardiopulmonary stress tests, cardiac magnetic resonance imaging, nuclear studies of myocardial function and perfusion, cardiac catheterization to better estimate pulmonary hypertension, and cardiac natriuretic hormone evaluation. Several vasodilator approaches (prostacycline or NO/endothelin) may counteract the microvascular dysfunction at peripheral and cardiopulmonary level, and fight the sequelae of pulmonary hypertension.
The Osmotic Swelling Characteristics of Cardiac Valve Prostheses (2000)

Several types of mechanical cardiac prostheses have been constructed with Delrin occluders, a material that is subject to osmotic swelling. The leaftets are designed to expand to specific tolerances when immersed in blood. The synthetic blood analogs commonly used in vitro contain hydrophilic compounds that can alter the osmotic expansion of the Delrin occluders. A static leak test chamber was employed to illustrate the effects of various test fluids on the sustained regurgitation phase of Delrin valves.
W-CDMA Channel Codec by Configurable Processors (2006)

Abstract On development of mobile communication terminals, a trade-off among performance, development period, and implementation flexibility is one of the most important issues. In this paper, an efficient architecture of channel codec is explored, dedicatedly for W-CDMA mobile communication standard. A pair of configurable processors are employed in our implementation, which are assigned to Turbo decoding and remaining processes. A set of specific instructions are introduced to both of the processors so as to enhance the execution of computationally intensive functions, which successfully reduce the execution cycles by 98% and 60%, respectively. As a result, real-time processing can be achieved in short development period, demonstrating that our implementation is feasible solution against the trade-off.
Neurocognitive Dysfunctions in Euthymic Bipolar Patients With and Without Prior History of Alcohol Use (2009)

Cognitive dysfunctions appeared to be more strongly associated with bipolar disorder than with the "history of alcohol abuse or dependence" factor. Bipolar patients with history of alcohol misuse may have greater difficulties of inhibitory control, probably due to higher impulsivity.
The anaerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia coli. Purification and characterization. (1981)

We have purified the membrane-extrinsic anaerobic glycerol-3-phosphate dehydrogenase from Escherichia coli using a strain harboring a recombinant ColE1:E. coli plasmid carrying the glpA gene. The purified enzyme is composed of subunits of 62,000 and 43,000 molecular weight in 1:1 molar ratio as determined by medium dodecyl sulfate polyacrylamide gel electrophoresis, sedimentation equilibrium, and chemical cross-linking studies. The presence of 20% ethylene glycol stabilizes the enzyme by preventing dissociation of the subunits. The purified enzyme contains 1 mol of noncovalently bound FAD and 2 mol of non-heme iron/dimer. The FAD can be reduced by addition of substrate and resides in the large subunit. Addition of exogenous flavins stimulates the rate of the enzymatic reaction, and the effects of FAD and FMN can be distinguished by the following properties: (i) FAD causes a 20% increase in enzymatic activity with a half-maximal concentration of 200 nM whereas FMN results in a 6-fold increase in activity with a half-maximal concentration of 130 microM. (ii) When methylene blue replaces phenazine methosulfate as an oxidation-reduction coupling dye, FAD stimulates the rate of the reaction, whereas FMN inhibits it. Limited proteolysis or treatment with sulfhydryl reagents does not affect activity but removes capacity for stimulation by exogenous flavins.
Bile Acids. Lxx. Preparative Separation of Kryptogenin from Companion Sapogenins by High Performance Liquid Chromatography (1984)

Abstract Commercial samples of kryptogenin or its acetate can be purified by preparative high performance liquid chromatography on a PrepPAK-500/Silica cartridge. The free alcohol is separated from accompanying sapogenin with a mixture of chloroform:methanol (50:1), whereas the acetates are separated well with a mixture of methylene chloride:hexane (2:3). The companion sapogenins, diosgenin and yamogenin, 25R- and 25S- isomers, were separated by analytical HPLC with hexane-isopropanol (100:1) or as the acetates with hexane:isopropanol (250:1). Characterization of kryptogenin and yamogenin was completed with 1H-NMR, IR and MS spectrometry.
The Impact of Cryoballoon Versus Radiofrequency Ablation for Paroxysmal Atrial Fibrillation on Healthcare Utilization and Costs: An Economic Analysis From the FIRE AND ICE Trial (2017)

URL: http://www.clinicaltrials.gov. Identifier: NCT01490814.
XXV. Zur Frage der Geschwindigkeit des Wachsthums und der Auflösung der Krystallflächen (1901)

Article XXV. Zur Frage der Geschwindigkeit des Wachsthums und der Auflösung der Krystallflächen was published on December 1, 1901 in the journal Zeitschrift für Kristallographie - Crystalline Materials (volume 34, issue 1-6).
ChemInform Abstract: New C2‐Chiral Bidentate Ligands Bridging the Gap Between Donor Phosphine and Acceptor Carbonyl Ligands. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effects of increasing space allowance by removing a pig or gate adjustment on finishing pig growth performance1,2 (2018)

A total of 256 pigs (initially 55.9 ± 4.88 kg) were used in a 71-d study to determine the effects of increasing space allowance and pig removal on pig growth performance. Pens of pigs were blocked by body weight (BW) and allotted to 1 of 4 space allowance treatments, initially with 8 pigs per pen and 8 pens per treatment. First 2 treatments included pens with 0.91 m2 per pig or 0.63 m2 per pig for the entire study; two additional treatments initially provided 0.63 m2 per pig, but either a gate was adjusted on days 28, 45, and 62 or the heaviest pig in the pen was removed from the pen on days 28 and 45 to provide more space and keep pigs in accordance with their predicted minimum space requirement [(m2) = 0.0336 × (BW, kg)0.67]. From days 0 to 14 (56 to 69 kg), there was no effect of stocking density observed for average daily gain (ADG), average daily feed intake (ADFI), and gain:feed (G:F). From days 14 to 28 (69 to 83 kg), pigs provided 0.91 m2 had increased (P < 0.05) ADG and G:F compared with those allowed 0.63 m2. Pigs provided 0.91 m2 were marginally heavier (P = 0.081) on day 28 and had greater ADFI (P = 0.025) during days 28 to 45 than those provided 0.63 m2 or those that had the heaviest pig removed. From days 45 to 62 (98 to 116 kg), pigs provided 0.91 m2 were heavier (P < 0.01) than all others, wheras pigs provided 0.63 m2 had reduced ADFI compared with other treatments. From days 62 to 71 (116 to 124 kg), pigs provided 0.91 m2 and those with space adjustment treatments had greater (P < 0.05) ADG and ADFI than those provided 0.63 m2. Overall (56 to 124 kg), pigs provided 0.91 m2 had increased (P = 0.001) ADG compared with those allowed 0.63 m2 with pigs provided space adjustments intermediate. In summary, pigs with 0.91 m2 grew faster and consumed more feed than pigs restricted in space. As pigs reached the critical k value, gate adjustments and pig removals affected growth similarly. As pigs grew to the predicted space requirement and were subsequently allowed more space, performance was greater than those provided 0.63 m2 but less than those allowed 0.91 m2. It appears that the industry accepted critical k value, 0.0336, may not be adequate for optimal pig performance across multiple BW ranges.
The Effect of Agitation on <i>In Vitro</i> Metabolism of Erythrocytes Stored in CPD‐Adenine (1975)

Agitation of blood stored in plastic containers has been reported to lead to improved posttransfusion survival and it has been found that, in some media, agitation has improved erythrocyte 2,3-diphosphoglycerate (2,3-DPG) levels. Using CPD II media (CPD with 277.5 mM glucose and 2.04 mM adenine), we were not able to identify any improvement in levels of adenosine triphosphate, 2,3-DPG or glucose in whole blood under various agitation conditions when compared with nonagitated control. The 2,3-DPG level was moderately improved through 28 days in the 90 per cent hematocrit packed erythrocytes but the results were not considered to be significantly beneficial to warrant agitation. Thus, the application of agitation to the CPD II blood storage system was of no great benefit in improving metabolic intermediate levels.
Quantitation of endogenous lectin expression in 3LL tumors, growing subcutaneously and in the kidneys of mice (1990)

By means of microdensitometry and image analysis, quantitative measurements were compared of endogenous lectin expression in tissue sections from 3LL carcinomas growing in the subcutis and kidneys of mice following the direct injection of cancer cells. The lectins were visualized by means of a modification of the ABC-peroxidase technique. In comparison with the subjective, visual inspection of similar materials reported previously, these quantitative techniques not only confirmed, but also provided additional information on site-associated changes in 3LL cell populations. Previously, 2 classes of cancer cells were recognized within the tumors on the basis of staining intensity, compared with 3 classes in the present study and, in addition, the relative areas occupied by these 3 densitometric classes were determined by image-analysis. Both "low" and "high" integrated intensities were significantly greater in the kidney tumors in 11 of 24 cases, and in 6 of 24 cases of s.c. tumors. The areas occupied by "high" and "low" intensity cells were significantly higher in 14 of 24 kidney tumors, and in 2 of 24 s.c. tumors. The results indicate often marked differences in endogenous lectin expression, between 3LL cancer cells from a common source, after direct delivery and growth in 2 different anatomic sites. These results indicate the necessity of taking into account analogous changes, when comparing these and other properties of cancer cell populations in metastases with those in primary tumors, with respect to both the generation of site-associated differences and their possible site-associated abrogation.
Optical and Discharge Studies of Novel Electronic Transition Laser Species (1980)

Summary of Conclusions from the Discharge S2 Laser Work: Electric discharges in pure S2 vapor do produce brilliant blue glow discharges characteristic of the S2(B-X) emission; Sulfur vapor is extremely corrosive and is effectively incompatible with all metal materials at 600 C.
A New Hexaferrocene Complex with a [M<sub>3</sub>(μ<sub>3</sub>-O)]<sup>7+</sup>Core (2006)

The new hexaferrocene complex 1 has been synthesized and characterized by X-ray diffraction. Its magnetization data were fitted to a detailed theoretical model that considers nonequivalent exchange parameters between Fe ions to yield the magnetic exchange coupling values of J1/kB = -31.5 K and J2/kB = -25.8 K. Moreover, the cyclic voltammogram of complex 1 confirmed its redox activity associated with the presence of ferrocene units, with very small or negligible electronic interactions between them.
Multi-modal MR Brain Segmentation Using Bayesian-based Adaptive MeanShift (BAMS) (2013)

In this paper, we validate our proposed segmentation algorithm called Bayesian-based adaptive mean-shift (BAMS) on real multimodal MR images provided by the MRBrainS challenge. BAMS is a fully automatic unsupervised segmentation algorithm. It is based on the adaptive mean shift wherein the adaptive bandwidth of the kernel for each feature point is estimated using our proposed Bayesian approach [1]. BAMS is designed to segment the brain into three tissues; white matter (WM), gray matter (GM) and cerebrospinal fluid (CSF). The performance of the algorithm is evaluated relative to the manual segmentation (ground truth). The results of our proposed algorithm show the average Dice index 0.8377±0.036 for the WM, 0.7637±0.038 for the GM and 0.6835 ± 0.023 for the CSF.
Growth and Reproductive Adaptation in Male Rats with Chronic Protein Deficiency (1984)

In previous studies, male rats fed a low-protein diet beginning at weaning were found to have impaired sexual development through age 11 weeks when compared to food-restricted, weight-matched controls fed a diet with normal protein content. To determine whether male rats show long-term adaptation of the reproductive axis to low-protein feeding, we assessed sexual maturation and growth in rats fed a low protein (9%) diet from weaning until sacrifice at various points in time between ages 79 and 185 days. After age 80 days, there was no difference in reproductive organ weights (prostate, seminal vesicles, testis) or serum hormone levels (luteinizing hormone, follicle stimulating hormone, testosterone) between protein-deficient animals and food-restricted weight-matched controls given a normal diet. In addition, there was no difference between protein-deficient animals and controls in indices of linear growth (naso-anal and tail length) or fatness (Lee index). We conclude that both growth and reproductive function of male rats show adaptation to long term feeding of a low-protein diet.
Intermolecular disulfide linkage in transferrin-HSA-conjugate is not reduced in the transferrin recycling pathway in K562 and CHO cells (1987)

It is assumed that prelysosomal cleavage of disulfide linkages occurs in endocytosed proteins such as insulin and immunotoxins. To study the reductive processes associated with receptor-mediated endocytosis, the authors used a conjugate of human transferrin (Tf) linked through a disulfide-bridge to radioiodinated or methotrexate (MTX)-labeled human serum albumin (HSA). Tf was modified with N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP) and reacted with reduced SPDP-modified /sup 125/I-HSA, to yield /sup 125/I-SHA-SS-Tf. The conjugate was isolated by gel filtration and, when tested on K562 cells, had a Kd of 7.2 nM. More than 95% of the conjugate internalized by K562 cells during a 2 hour incubation at 37/sup 0/C was recycled after a 2 hr chase at 37/sup 0/C. SDS-PAGE analysis of the recycled radioactivity revealed that the intermolecular disulfide conjugate was intact. Further treatment of the recycled conjugate with 2-mercaptoethanol resulted in complete regeneration of /sup 125/I-HSA. MTX-HSA-SS-Tf was compared to its non-reducible thioether analogue, MTX-HSA-S-Tf.
Successful Treatment of Refractory Low Grade Duodenal Lymphoma With Rituximab, an Anti-cd20 Monoclonal Antibody (2003)

Duodenal lymphoma accounts for a small percentage of gastrointestinal tumors and has a very poor prognosis. The majority of patients have little or no cure with limited time of remission. Median survival is 5 to 10 years, and most patients die of lymphoma, its complications, or complications of therapy. We report a patient with lymphoma refractory to treatment with cyclophosphamide, vincristine, and prednisone, who was successfully treated with rituximab, a CD-20 monoclonal antibody.
Temperature Dependence of the Gorter-Mellink Exponent m Measured in a Channel Containing He II (2006)

Steady state heat transport through He II was investigated. The exponent m in the Gorter‐Mellink equation which gives heat flux dependence of the temperature gradient was measured in a wide range of heat flux. Our results indicate that there is no heat flux dependency of the exponent m in the heat flux region of our measurement. The exponent m is 3.4 at temperatures much lower than the lambda point and decreases down to 3.3 as the temperature approaches the lambda point.
Functional Analysis for Computers (1969)

In order to take further advantage of the high speed of computers it is of interest to consider the possibility of mechanizing some parts of functional analysis. An approach based on computations with interval valued functions is discussed.
Mechanism of interfacial mass transfer in membrane transport (1968)

Abstract Dialysis of binary aqueous solutions of several sugars through a cellophane membrane was studied in a stirred batch dialyzer. Sherwood numbers describing mass transfer resistance in the fluid adjacent to the membrane were determined as a function of the corresponding Reynolds and Schmidt numbers. The results establish a reproducible environment for membrane testing in which a known controllable and small interfacial resistance is placed in series with that of the membrane. The results are also shown to support, for this geometry, the postulation of a third power relationship between eddy diffusivity and dimensionless distance from the phase boundary as well as the Sherwood‐Ryan nondimensionalization of this distance.
Multivariate Analysis of Risk Factors for Death Following Gastric Bypass for Treatment of Morbid Obesity (2004)

The risk factors for perioperative death can be separated into patient characteristics and complications. The access method, open versus laparoscopic, was not independently predictive of death, but the operation type, proximal versus long limb, was predictive. The data do not suggest that superobese patients should not undergo surgery, as they are high risk for early death due to their body weight and comorbidities without surgery. Surgery should not be reserved as a desperate last measure for weight loss.
Pathogenesis of Bacterial Diarrheas (1971)

NO less than a renaissance has emerged in studies of diarrhea, in spite of the unattractive attributes of feces, the difficulty in identifying pathogens among a sea of other bacteria, and the consequent belief that identification may come too late to influence therapy. The increasing apposition of the interests of temperate and tropical countries has prompted an awareness of the global importance of enteric diseases and has attracted considerable research support. In the information explosion that has followed, the traditional concerns of microbiologists and epidemiologists have been influenced by immunologists and physiologists belatedly recognizing the unique experiments of nature that . . .
GYRATE ATROPHY-LIKE PHENOTYPE WITH NORMAL PLASMA ORNITHINE (1997)

A gyrate atrophy-like phenotype can result from causes other than deficient ornithine-delta-aminotransferase. Its occurrence in three male members in two generations in one family suggests an autosomal dominant inheritance in at least some such patients.
Multi-Institutional Validation of a New Renal Cancer–Specific Survival Nomogram (2007)

The new nomogram is more contemporary, provides predictions that reach further in time and, compared with its alternative, which predicts at 2 and 5 years, generates 3.1% and 2.8% more accurate predictions, respectively.
An AC-Coupled Wideband Neural Recording Front-End With Sub-1 mm<sup>2</sup>×fJ/conv-step Efficiency and 0.97 NEF (2020)

This letter presents an energy-and-area-efficient ac-coupled front-end for the multichannel recording of wideband neural signals. The proposed unit conditions local held and action potentials using an inverter-based capacitively coupled low-noise amplifier, followed by a per-channel 10-b asynchronous SAR ADC. The adaptation of unit-length capacitors minimizes the ADC area and relaxes the amplifier gain so that small coupling capacitors can be integrated. The prototype in 65-nm CMOS achieves 4× smaller area and 3× higher energy-area efficiency compared to the state of the art with 164 μm×40 μm footprint and 0.78 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ×fJ/conv-step energy-area figure of merit. The measured 0.65-μW power consumption and 3.1-μVrms input-referred noise within 1 Hz-10 kHz bandwidth correspond to a noise efficiency factor of 0.97.
Traumatic biliary stricture successfully treated by percutaneous transhepatic bile duct dilatation: a case report. (1999)

A 24 year-old woman complained of obstructive jaundice 24 days after blunt abdominal trauma due to a traffic accident. Endoscopic retrograde cholangiopancreatography (ERCP) revealed a stricture, 15 mm in length, at the common bile duct associated with upper bile duct dilatation. Jaundice was reduced by percutaneous transhepatic cholangio-drainage (PTCD). A 7 Fr-sized PTCD tube was exchanged for a larger-sized catheter for percutaneous transhepatic cholangioscopy expecting gradual dilatation of the stricture. Following the confirmation of satisfactory dilatation of the stricture, the catheter was removed. There was no recurrence of jaundice 16 months later in a follow-up study.