gebhart/patrepeval huggingface dataset:
Role of TERRA in the Regulation of Telomere Length (2015)

Telomere dysfunction is closely associated with human diseases such as cancer and ageing. Inappropriate changes in telomere length and/or structure result in telomere dysfunction. Telomeres have been considered to be transcriptionally silent, but it was recently demonstrated that mammalian telomeres are transcribed into telomeric repeat-containing RNA (TERRA). TERRA, a long non-coding RNA, participates in the regulation of telomere length, telomerase activity and heterochromatinization. The correct regulation of telomere length may be crucial to telomeric homeostasis and functions. Here, we summarize recent advances in our understanding of the crucial role of TERRA in the maintenance of telomere length, with focus on the variety of mechanisms by which TERRA is involved in the regulation of telomere length. This review aims to enable further understanding of how TERRA-targeted drugs can target telomere-related diseases.
Biological control of Phytophthora root rot of avocato with microorganisms grown in organic mulches (2000)

Organic mulches colonized with microbial biocontrol agents, termed bioenhanced mulches, were tested for their ability to reduce Phytophthora root rot of avocado (Persea americana Mill.). Benomyl-resistant mutants of Gliocladium virens (KA 230-1) and Trichoderma harzianum (KA 159.2) isolated from suppressive soils and selected as efficient antagonists of P. cinnamomi were evaluated for their ability to colonize different mulches under controlled laboratory conditions. Sudangrass and a coarse yardwaste were found to be better substrates than a fine yardwaste, woodwaste or rice hulls for biocontrol agents propagules production. The most suitable conditions for colonization were an optimum temperature of 24°C, a moisture content of 20% for sudangrass and 30% for the coarse yardwaste, and a continuous light exposure during a 15-day incubation period. In the greenhouse, fresh sudangrass and a coarse yardwaste colonized with G. virens and used as a surface mulch proved to be the best combination for reducing the population of P. cinnamomi in 4-liter pots containing artificially-infested soil. Healthy avocado roots made up 31-37% of the roots in the G. virens-mulch combinations compared to 0% healthy in infested controls after two months.
Maximum likelihood signal estimation for polarization sensitive arrays (1993)

The authors consider the problem of separating and estimating the waveforms of superimposed signals received by a polarization-sensitive array. Signal estimation is accomplished by a two-step maximum likelihood procedure: (i) The directions of arrival and polarization parameters of all the signals are estimated. (ii) The estimated signal is obtained as a linear combination of the array outputs, with weights which are computed from the estimated direction/polarization parameters. The objective of this study is to analyze the quality of the estimated signal in terms of the output signal-to-interference ratio (SIR) and output signal-to-noise ratio (SNR). Closed-form expressions are derived for the output SIR and SNR of a general diversely polarized array. By evaluating these expressions for selected test cases it is shown that polarization-sensitive arrays can provide significantly higher output SIR and SNR than uniformly polarized arrays. The performance improvement is especially significant for closed spaced sources with sufficiently different polarization characteristics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Unsupervised discovery of object classes in 3D outdoor scenarios (2011)

Designing object models for a robot's detection-system can be very time-consuming since many object classes exist. This paper presents an approach that automatically infers object classes from recorded 3D data and collects training examples. A special focus is put on difficult unstructured outdoor scenarios with object classes ranging from cars over trees to buildings. In contrast to many existing works, it is not assumed that perfect segmentation of the scene is possible. Instead, a novel hierarchical segmentation method is proposed that works together with a novel inference strategy to infer object classes.
A Fair Scheduling for Wireless Mesh Networks (2005)

Wireless Mesh Networks (WMNs) represent a new and promising paradigm that uses multi-hop communications to extend WiFi networks: By deploying only one hot spot (directly connected to the Internet) and several transient access points (TAPs), an Internet Service Provider (ISP) can extend its coverage and serve a large number of clients using a single broadband connection. Unfortunately, if the medium access protocol is poorly designed or inadequate, it can lead to severe unfairness and low bandwidth utilization. In this paper, we propose a fair scheduling mechanism that optimizes the bandwidth utilization in the mesh network. Our solution assigns transmission rights to the links in the WMN and maximizes the spatial reuse (i.e., the possibility for links that do not contend to be activated at the same time). We show that our solution is fair and collision-free, and we evaluate its efficiency by means of simulations.
Suppressing stimulated Brillouin scattering in fiber amplifiers using nonuniform fiber and temperature gradient (2007)

A nonuniform large mode area fiber having an larger core at most locations to reduce power intensity and having a relatively smaller core at certain locations to reduce bending sensitivity is proposed for suppression of stimulated Brillouin scattering (SBS) in a high power fiber amplifier. A comprehensive model taking into account fiber nonuniformity, profile and temperature gradient shows that the fiber can achieve kilowatt output at a temperature gradient of >250 degrees C. Compared with a conventional large mode area fiber, a total of 7 dB SBS suppression can be achieved using this unique fiber.
Microemulsions of Pyrethroids : Phase Diagrams and Effectiveness of Tristyrylphenol Based Surfactants (1993)

Tristyrylphenol based surfactants exhibit an excellent ability to microemulsify pyrethroids. A systematic construction of phase diagrams has shown that microemulsions made with these surfactants are not temperature sensitive. The effectiveness of a surfactant blend can be measured by the amount which is necessary to obtain a microemulsion at a water/oil ratio equal to one. These type of surfactants are in this sense more effective than nonylphenols. The main role of cosurfactant molecules is to disorder the lamellar organization of surfactant layers. The lamellar structure is locally conserved in microemulsions.
Clinical Implications of Inflammatory Cytokines in the Cochlea: A Technical Note (2002)

Production of inflammatory cytokines by the above-mentioned cells indicates that they are vulnerable to disruption by extra-cochlear sources of cytokines and associated ligands. These cells play critical roles in cochlear function, and their disruption could induce hearing loss. These findings suggest that systemic or local production of inflammatory ligands may play roles in a number of causes of deafness, including immune mediated hearing loss, sudden hearing loss, and sensorineural hearing loss associated with otosclerosis, otitis media, and bacterial meningitis.
Schloss Dagstuhl - Jahresbericht / Annual Report 2016 (2017)

Schloss Dagstuhl -- Leibniz-Zentrum fuer Informatik setzt sich zum Ziel, Informatikforschung auf Weltklasseniveau zu unterstuetzen und Wissenschaftsseminare zu beherbergen, in denen neue Ideen untersucht und Probleme diskutiert werden, um Grundsteine fur neue Entwicklungen in der Informatik zu legen. Der Jahresbericht 2016 gibt einen detaillierten Ueberblick ueber das wissenschaftliche Programm und weiterer Aktivititaeten des Jahres 2016. Schloss Dagstuhl -- Leibniz-Zentrum fuer Informatik promotes world-class research in informatics and hosts research seminars in which new ideas are showcased, problems discussed, and the course set for future development in a specific field of informatics. This annual report provides a detailed overview of the scientific program, activities, and overall work of the center in 2016.
When the JIT Starts to Fly Is It Time to Keep Your Head down or Go forISC? (1994)

For many manufacturing companies reaching forward into Europe. Just‐in‐time (JIT) implementation is merely the start of the race. This may be difficult for those in the materials function who saw MRP as the be‐all‐and‐end‐all. Yet the integrated supply chain (ISC) cannot be tackled without the experience gained from MRP and JIT. Discusses, given that JIT is a prerequisite for ISC, how JIT can be used to advantage in an ISC culture.
Proust Was a Neuroscientist (2007)

Is science the only path to knowledge? In this sparkling and provocative book, Jonah Lehrer explains that when it comes to understanding the brain, art got there first. Taking a group of celebrated writers, painters and composers, Lehrer shows us how artists have discovered truths about the human mind - real, tangible truths - that science is only now rediscovering. We learn, for example, how Proust first revealed the fallibility of memory; how George Eliot understood the brain's malleability; how the French chef Escoffier intuited umami (the fifth taste); how Cezanne worked out the subtleties of vision; and how Virginia Woolf pierced the mysteries of consciousness. It's a riveting tale of art trumping science again and again.
On-line dead-time compensation method for permanent magnet synchronous motor drive (2003)

This paper presents an on-line dead-time compensation method for inverter fed permanent magnet synchronous motor drives. The dead-time compensation voltage is adaptively adjusted by identifying the dead-time compensation time. The dead-time compensation time can be identified on-line with using the disturbance observer. Comparison between the commanded and actual voltages demonstrates the validity of the proposed method.
Deep auto-encoder based clustering (2014)

For unsupervised problems like clustering, linear or non-linear data transformations are widely used techniques. Generally, they are beneficial to data representation. However, if data have a complicated structure, these techniques would be unsatisfying for clustering. In this paper, we propose a new clustering method based on the deep auto-encoder network, which can learn a highly non-linear mapping function. Via simultaneously considering data reconstruction and compactness, our method can obtain stable and effective clustering. Experimental results on four databases demonstrate that the proposed model can achieve promising performance in terms of normalized mutual information, cluster purity and accuracy.
Energy-Efficient Building Systems: Green Strategies for Operation and Maintenance (2006)

Preface Abbreviations and Terms Used Chapter 1: Energy Management and Energy Auditing Chapter 2: Air-Conditioning and Central Chiller Systems Chapter 3: Boilers and Heating Systems Chapter 4: Pumping Systems Chapter 5: Cooling Towers Chapter 6: Air Handling and Distribution Systems Chapter 7: Lighting Systems Chapter 8: Building Electrical Systems Chapter 9: Building Automation Systems Chapter 10: Building Envelope Bibliography Appendix A: Reference Data for Boiler Operations Appendix B: Enthalpy of Moist Air Index
Adaptive exposure estimation for high dynamic range imaging applied to natural scenes and daylight skies (2015)

Digital imaging of natural scenes and optical phenomena present on them (such as shadows, twilights, and crepuscular rays) can be a very challenging task because of the range spanned by the radiances impinging on the capture system. We propose a novel method for estimating the set of exposure times (bracketing set) needed to capture the full dynamic range of a scene with high dynamic range (HDR) content. The proposed method is adaptive to scene content and to any camera response and configuration, and it works on-line since the exposure times are estimated as the capturing process is ongoing. Besides, it requires no a priori information about scene content or radiance values. The resulting bracketing sets are minimal in the default method settings, but the user can set a tolerance for the maximum percentage of pixel population that is underexposed or saturated, which allows for a higher number of shots if a better signal-to-noise ratio (SNR) in the HDR scene is desired. This method is based on the use of the camera response function that is needed for building the HDR radiance map by stitching together several differently exposed low dynamic range images of the scene. The use of HDR imaging techniques converts our digital camera into a tool for measuring the relative radiance outgoing from each point of the scene, and for each color channel. This is important for accurate characterization of optical phenomena present in the atmosphere while not suffering any loss of information due to its HDR. We have compared our method with the most similar one developed so far [IEEE Trans. Image Process.17, 1864 (2008)]. Results of the experiments carried out for 30 natural scenes show that our proposed method equals or outperforms the previously developed best approach, with less shots and shorter exposure times, thereby asserting the advantage of being adaptive to scene content for exposure time estimation. As we can also tune the balance between capturing time and the SNR in our method, we have compared its SNR performance against that of Barakat's method as well as against a ground-truth HDR image of maximum SNR. Results confirm the success of the proposed method in exploiting its tunability to achieve the desired balance of total Δt and SNR.
A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. (1993)

Subepidermal blistering associated with the human skin diseases bullous pemphigoid and herpes gestationis has been thought to be an IgG autoantibody-mediated process; however, previous attempts to demonstrate the pathogenicity of patient autoantibodies have been unsuccessful. An immunodominant and potentially pathogenic epitope associated with these blistering diseases has recently been mapped to the extracellular domain of a human epidermal antigen, BP180. Patient autoantibodies that react with this well-defined antigenic site failed to crossreact with the murine form of this autoantigen and thus could not be assayed for pathogenicity in a conventional passive transfer mouse model. As an alternative, rabbit polyclonal antibodies were generated against a segment of the murine BP180 protein homologous with the human BP180 autoantibody-reactive site and were passively transferred into neonatal BALB/c mice. The injected animals developed a subepidermal blistering disease that closely mimicked bullous pemphigoid and herpes gestationis at the clinical, histological, and immunological levels. Autoantibodies that recognize the human BP180 ectodomain are therefore likely to play an initiatory role in the pathogenesis of bullous pemphigoid and herpes gestationis.
ICLH Replacement of the Knee (1979)

Investigations which began in 1968 have culminated in a knee arthroplasty which can now be confidently used to treat most patients with arthritic knee deformities. Our earlier studies showed that a prosthetic knee arthroplasty must be reliably aligned and stabilized in extension, that patellar pain and polyethelene wear were significant potential problems and that loosening and sinkage of the tibial component must be avoided. Our present knee prosthesis and instrumentation if properly used should avoid these pitfalls. Beginning in January 1977 we performed 84 knee arthroplasties utilizing the present design. A series of 79 knees has been available for our computer-assisted review; 46 patients had a diagnosis of inflammatory arthritis and 29 had primary osteoarthrosis: 22 knees had been previously operated upon. Although all femoral components were fixed with polymethylmethacrylate, the tibial components were completely cemented in 21 knees, partially cemented in 20, and no cement was used in 38 cases. In these latter knees special pegs provided a mechanical interlock with the tibia for fixation. Thirty-six patellae were replaced, of which 11 were fixed with a similar interlocking peg. The arthroplasties failed in 8 patients. Of the remainder, 90% of knees had acceptable pain relief and all but 4 patients were able to walk outdoors. Flexion to 90 degrees or more was achieved in 85% of the knees. Only 2 patients had unacceptable alignment. To date we feel that with the use of this improved prosthesis, in conjunction with the instruments which allow proper placement of the prosthesis, the majority of arthritic knees can be successfully corrected. However, further careful long-term follow-up studies must continue.
Livestock diet utilization: Natural vegetation and cultivated feedstuffs should have favorable ratio to value of animal products they produce (1952)

The proper livestock diet utilizes natural vegetation and cultivated feed-stuffs to maintain continuous animal growth.
Depositing light in a photonic stop gap by use of Kerr nonlinear microresonators (2003)

We show theoretically that it is possible to trap light in a microresonator structure by use of four-wave mixing. The efficiency of the parametric process is substantially increased by the high group delay of light inside the structure. The energy that is trapped has a half-life of approximately 500 ps in the presence of both linear and nonlinear loss in the channel waveguides and resonators. We also demonstrate that the energy can be extracted from the cavity with a similar process.
L-acetylcarnitine treatment of mental decline in the elderly. (1994)

A single-blind clinical trial was carried out on 481 subjects enrolled in 44 geriatric and neurologic units following a strict selection criteria: age, Mini Mental State Examination (MMSE) Global Deterioration Scale and Geriatric Depression Scale (GDS). After the initial screening and enrollment, the trial was run for 150 days in four phases: phase T0 (placebo treatment for 30 days), phases T1 and T2 (L-acetylcarnitine (LAC) 1500 mg/day for 90 days), phase T3 (further 30 days of placebo treatment). Drug efficacy was evaluated according to changes occurring from the beginning to the end of the tests which evaluate either whole and specific cognitive performances, or emotional-affective and relational behaviour. The outcome of phase T3 enabled the authors to estimate the possible favourable effects persisting after termination of L-acetylcarnitine therapy. The cognitive sphere evaluated by MMSE showed a significant increase in the total score at the end of LAC treatment (p < 0.0001). The Randt Memory Test also revealed that LAC treatment improved the items tested: the total score and the memory index increased significantly and the favourable effect persisted after LAC was discontinued. The emotional-affective area showed a significant improvement in the total score of the GDS after LAC therapy, and the positive results were confirmed by the Hamilton Rating Scale (p < 0.0001). The behavioural-relational aspects evaluated by the Family Stress Scale showed a significant decrease in the total score after treatment (p < 0.0004); the same trend was observed in the scores for instability and negative feeling. No significant adverse drug reaction occurred during the trial. In conclusion, the statistical analysis of the data from this single-blind, multicentre trial of mild mental impairment in the elderly showed a significant improvement of several performances during and after LAC treatment. Other reports indicate that this drug may be effective in the treatment of dementia.
Array Designs Optimized for Both Low-Frequency NAH and High-Frequency Beamforming (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Transcriptional Profiling of the Chicken Tracheal Response to Virulent Mycoplasma gallisepticum Strain R <sub>low</sub> (2017)

<i>Mycoplasma gallisepticum</i>, the primary etiologic agent of chronic respiratory disease (CRD) in poultry, leads to prolonged recruitment and activation of inflammatory cells in the respiratory mucosa. This is consistent with the current model of immune dysregulation that ostensibly allows the organism to evade clearance mechanisms and establish chronic infection. To date, studies using quantitative reverse transcription-PCR (qRT-PCR) and microarrays have shown a significant transient upregulation of cytokines and chemokines from tracheal epithelial cells (TECs) <i>in vitro</i> and tracheal tissue <i>ex vivo</i> in response to virulent strain R<sub>low</sub> that contributes to the infiltration of inflammatory cells into the tracheal mucosa. To expand upon these experiments, RNA was isolated from tracheas of 20 chickens infected with <i>M. gallisepticum</i> R<sub>low</sub> and 20 mock-infected animals at days 1, 3, 5, and 7 postinoculation, and samples were analyzed for differential gene expression using Illumina RNA sequencing. A rapid host response was observed 24 h postinfection, with over 2,500 significantly differentially expressed genes on day 3, the peak of infection. Many of these genes have immune-related functions involved in signaling pathways, including Toll-like receptor (TLR), mitogen-activated protein kinase, Jak-STAT, and the nucleotide oligomerization domain-like receptor pathways. Of interest was the increased expression of numerous cell surface receptors, including TLR4 and TLR15, which may contribute to the production of cytokines. Metabolic pathways were also activated on days 1 and 3 postinfection, ostensibly due to epithelial cell distress that occurs upon infection. Early perturbations in tissue-wide gene expression, as observed here, may underpin a profound immune dysregulation, setting the stage for disease manifestations characteristic of <i>M. gallisepticum</i> infection.
THE BASIC PROPERTIES OF OXYGEN. II. (1913)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE BASIC PROPERTIES OF OXYGEN. II.O. Maass and D. McIntoshCite this: J. Am. Chem. Soc. 1913, 35, 5, 535–543Publication Date (Print):May 1, 1913Publication History Published online1 May 2002Published inissue 1 May 1913https://pubs.acs.org/doi/10.1021/ja02194a003https://doi.org/10.1021/ja02194a003research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts