gebhart/patrepeval huggingface dataset:
Slotted pore microfilters for oil/water filtration, fractionation and aggressive filtration environments (2004)

In the UK, researchers have been investigating ways of separating oil and other particles from water. They have developed and designed a new filter that uses microfiltration media that are similar to very fine sieves. Furthermore, there is no internal deposition of solids, and the pressure that is required to pass liquids through the media is low. This article provides details of this technology, which could be used on offshore oil rigs to vastly reduce the amount of oil discharged into the world's oceans.
A miniature, implantable wireless neural stimulation system (2006)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.
Induction of Interleukin-22 (IL-22) production in CD4<sup>+</sup>T Cells by IL-17A Secreted from CpG-Stimulated Keratinocytes (2016)

Since IL-22 is an important mediator for psoriatic inflammation, our data suggest that keratinocytes can participate in the pathogenesis of psoriasis via the TLR9-dependent IL-17A production.
Epidermal intercellular binding of concanavalin a and pemphigus antibody (1975)

The binding sites of Concanavalin A (Con A) and pemphigus antibody in the intercellular spaces of the human epidermis have been investigated. Extraction of human skin with phosphate-buffered saline (PBS) and 70% ethanol resulted in complete loss of the binding sites of the pemphigus antibody, whereas the extracted skin still retained its reactivity to Con A. Preincubation with more than 0.25 mg/ml of Con A with normal skin caused a reduction in the binding of pemphigus sera. However, preincubation of pemphigus sera with human skin caused no inhibition of the subsequent binding of fluorescein-labelled Con A. These results indicate that Con A binding sites might be related to, but not identical with those of pemphigus antibody.
ChemInform Abstract: Oxygenation Reaction Catalyzed by Manganese(II) Acetate or VO(OEt)Cl2 in the Presence of a Nitrogen Ligand. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Origins of Human Embryonic Stem Cells: A Biological Conundrum (2007)

Human inner cell mass (ICM) cells isolated from in vitro fertilized blastocysts are the progenitor cells used to establish in vitro stable human embryonic stem cells (hESCs) which are pluripotent and self-renew indefinitely. This long-term perpetuation of hESCs in the undifferentiated state is thought to be an in vitro adaptation of the ICM cells. To investigate at the molecular level how hESCs acquired their unique properties, transcriptional profiles of isolated ICM cells and undifferentiated hESCs were compared. We identified 33 genes enriched in the ICM compared to the trophectoderm and hESCs. These genes are involved in signaling cascades (SEMA7A and MAP3K10), cell proliferation (CUZD1 and MS4A7) and chromatin remodeling (H1FOO and HRMT1L4). Furthermore, primordial germ cell-specific genes (SGCA and TEX11) were detected as expressed in the ICM cells and not hESCs. We propose that the transcriptional differences observed between ICM cells and hESCs might be accounted for by adaptive reprogramming events induced by the in vitro culture conditions which are distinct from that of in vitro fertilized blastocysts. hESCs are a distinct cell type lacking in the human embryo but, nonetheless, resemble the ICM in their ability to differentiate into cells representative of the endodermal, ectodermal and mesodermal cell lineages.
Structure of di-n-propyl dibenzobarrelene-11,12-dicarboxylate (1991)

C 24 H 24 O 4 cristallise dans P1 avec a=9,6978, b=10,2945, c=10,3828 A, α=82,414, β=81,671, γ=85,817 o , Z=2; affinement jusqu'a R=0,067. Les deux groupements carboxyl ont des orientations differentes par rapport a la liaison C(11)=C(12); les angles de torsion C=C-C=0 sont de −107,3 o en C(11) et de −175,1 o en C(12)
S49 Increased skeletal muscle-specific microRNA-1 in the blood of COPD patients (2011)

<h3>Introduction</h3> Quadriceps muscle dysfunction is an important prognostic comorbidity in COPD. MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression. Skeletal muscle expresses a number of tissue-specific microRNA including miR-1, which modulates muscle phenotype. MicroRNAs can be secreted from cells and maintained in blood within exosomes. Elevated levels of circulating miR-1 have been demonstrated in a number of human and animal models of muscle disease. We hypothesised that plasma levels of miR-1 would be elevated in COPD patients and would correlate with important physiological parameters. <h3>Methods</h3> 103 COPD patients and 25 controls were studied. MiR-1 was quantified in stored plasma samples using q-RT PCR.1 MiR-16 and miR-122 were quantified as negative controls. Results were normalised to an exogenous spiked-in control. <h3>Results</h3> Characteristics as mean (SD); COPD patients: M: 67, F: 36, age=66.47 (8.4), FEV<sub>1</sub> % pred= 43.5 (18.6), 6-minute walk (6MW) = 394 (120). Controls: M: 14, F: 11, age=67 (8.1), FEV<sub>1</sub> % pred=111.2 (13.1), 6MW=613 (83). Plasma miR-1 was significantly elevated in COPD patients, p=0.002. There was no difference in miR-16 and miR-122. MiR-1 was negatively associated with FEV<sub>1</sub> % predicted (r =−0.3, p<0.001) and with Tlco (r=−0.3, p<0.001), but it was not possible to distinguish between GOLD stages using ANOVA. However, if patients were sub-divided into early GOLD stage COPD (1 and 2) or late GOLD stage COPD (3 and 4), miR-1 was significantly higher in the latter group (p=0.02). The plasma level of miR-1 was inversely correlated with daily activity measured as locomotion time (r= −0.25, p<0.01) but miR-1 levels were not associated with any muscle phenotype or with muscle-specific gene expression. <h3>Conclusion</h3> Our results show that stable COPD patients have elevated plasma levels of muscle-specific miR-1. The increase in miR-1 may be due to increased muscle degradation or turnover in the COPD patients studied. Our work raises the possibility of using other muscle-specific microRNAs in the future as potential biomarkers of muscle dysfunction in patients with COPD.
Functionalization of single-walled carbon nanotubes for direct and selective electrochemical detection of DNA (2010)

We report here a new strategy to graft both redox and DNA probes on carbon nanotubes to make a label-free DNA sensor. Oxidized single-walled carbon nanotubes are first immobilized on a self-assembled monolayer of cysteamine; then the redox probe, a quinone derivative 3-[(2-aminoethyl)sulfanyl-5-hydroxy-1,4-naphthoquinone], is grafted on the free carboxylic groups of the nanotubes. After that, for DNA probe grafting, new carboxylic sites are generated via an aryl diazonium route. After hybridization with a complementary sequence, the conformational changes of DNA could influence the redox kinetics of quinone, leading to a current increase of the redox signal, detected by square wave voltammetry. The system is selective, as it can discriminate a single mismatched sequence from the complementary one.
Abstract 32: Ly6C <sup>Lo</sup> Monocyte/Macrophages Are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis (2017)

Venous thrombosis (VT) results in vein wall injury by promoting inflammation and fibrosis leading to venous reflux, swelling, pain, and potentially, recurrent thrombosis. While prior work has shown that infiltrating leukocytes are important for VT resolution, as of yet, the precise roles of different leukocyte subsets are not well understood. Monocyte/macrophages (Mo/MΦs) are essential for the repair and resolution of tissue injury in other models, and come in inflammatory (Ly6C Hi ) or pro-resolution (Ly6C Lo ) subtypes. We hypothesized that infiltrating Mo/MΦs would be critical to VT resolution. In order to study this in vivo , we utilized a conditional macrophage depletion technique, using CD11b-DTR mice, to examine the effects of Mo/MΦs in a murine model of stasis VT by inferior vena cava ligation. Administration of 10ng/g diphtheria toxoid (DTx) every 48 hours by intra-peritoneal injection in CD11b-DTR mice resulted in an 89% and 55% decrease in circulating monocytes at 24hrs and 48hrs, respectively. When compared to saline controls, DTx injection had no effects on thrombogenic response or IVC thrombus cell populations in C57BL/6 control mice. At 8 days’ post-ligation, DTx treated CD11b-DTR mice had preferentially decreased vein wall-thrombus Ly6C Lo Mo/MΦs as compared with controls. DTx treated mice had significantly larger thrombi (1.7-fold) and less TGF-β, FSP-1, and plasminogen by western immunoblotting (all P-values ≤ 0.01). Consistent with a reduction in Ly6C Lo Mo/MΦs was a significant decrease in cellular TGF-β by intra-cellular flow cytometry. These findings suggest that Ly6C Lo Mo/MΦs are essential for normal VT resolution and may promote thrombus resolution via a plasminogen-mediated mechanism.
Electrically Tunable Single-Photon Source Triggered by a Monolithically Integrated Quantum Dot Microlaser (2017)

We report on a quantum dot micropillar-based single-photon source demonstrating tunable emission energy via an applied electric field and driven by an on-chip, whispering-gallery-mode microlaser. In this concept the cavity-enhanced single-photon source is monolithically integrated with an electrically driven, coherent excitation source. The device concept features low laser-threshold currents of a few tens of μA, has a small footprint of ∼200 μm2 and demonstrates high single-photon purity with g(2)(0) as low as 0.07 ± 0.03 under pulsed electrical excitation of the microlaser. The electric field applied along the growth direction of the single-photon emitter allows the emission to be tuned by up to 1.1 meV via the quantum-confined Stark effect, bringing it into resonance with the fundamental mode of the surrounding micropillar resonator for enhanced emission via the Purcell effect.
<title>Active damping of flexible rotor blade dynamics using electrorheological-fluid-based actuators</title> (1994)

Advanced rotor systems including hingeless and bearingless rotors have air and ground resonance instabilities due to coalescence of low-frequency rotor modes with landing gear and fuselage modes, respectively. This coalescence is of difficulty due to the direct connection of the rotor blade in these advanced rotor systems to the rotor hub using a flexure or flexbeam. We are currently exploring the mitigation of this modal coalescence through the use of active damping techniques and electro-rheological fluid technology.
UNIX System V Release 4: An Introduction (1990)

Part 1 Basics: getting started files and directories working with files and directories shell c shell and korn shell. Part 2 Text editing and processing: text editing with Ed advanced text editing introduction to text processing advanced text processing. Part 3 Networking: mail basic networking utilities networking with TCP/IP the Internet. Part 4 Tools: UNIX tools shell programming I shell programming II Awk Perl. Part 5 System administration: UNIX processes security basic system administration advanced system administration client/server computing network administration and networking. Part 6 User environments: user interfaces and multimedia DOS and UNIX together UNIX applications development environment appendices.
Antispasmodics. III.<sup>1</sup> Esters of Basic Bicyclic Alcohols and Their Quaternary Salts (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntispasmodics. III.1 Esters of Basic Bicyclic Alcohols and Their Quaternary SaltsL. H. Sternbach and S. KaiserCite this: J. Am. Chem. Soc. 1953, 75, 23, 6068–6069Publication Date (Print):December 1, 1953Publication History Published online1 May 2002Published inissue 1 December 1953https://pubs.acs.org/doi/10.1021/ja01119a534https://doi.org/10.1021/ja01119a534research-articleACS PublicationsRequest reuse permissionsArticle Views121Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: A FACILE METHOD FOR MONOACETYLATION OF SYMMETRICAL DIOLS: APPLICATION TO THE TOTAL SYNTHESIS OF Z‐8‐DODECENYL ACETATE, THE SEX ATTRACTANT OF THE ORIENTAL FRUIT MOTH (1979)

Abstract Aus den langkettigen Diolen (I) entstehen nach Monoveresterung zu (II) die Aldehydester (III), die nach Wittig mit (IV) zu den Olefinen (V) kondensiert werden.
Video surveillance of pedestrians and vehicles (2007)

In this paper, we focus on the problem of automated surveillance in a parking lot scenario. We call our research system VANESSA, for Video Analysis for Nighttime Surveillance and Situational Awareness. VANESSA is capable of: 1) detecting moving objects via background modeling and false motion suppression, 2) tracking and classifying pedestrians and vehicles, and 3) detecting events such as person entering or exiting a vehicle. Moving object detection utilizes a multi-stage cascading approach to identify pixels that belong to the true objects and reject any spurious motion, (e.g., due to vehicle headlights or moving foliage). Pedestrians and vehicles are tracked using a multiple hypothesis tracker coupled with a particle filter for state estimation and prediction. The space-time trajectory of each tracked object is stored in an SQL database along with sample imagery to support video forensics applications. The detection of pedestrians entering/exiting vehicles is accomplished by first estimating the three-dimensional pose and the corresponding entry and exit points of each tracked vehicle in the scene. A pedestrian activity model is then used to probabilistically assign pedestrian tracks that appear or disappear in the vicinity of these entry/exit points. We evaluate the performance of tracking and pedestrian-vehicle association on an extensive data set collected in a challenging real-world scenario.
Condition Based Coating Degradation Sensor (2002)

Abstract Atmospheric corrosion of steels, aluminum alloys, and Al-clad aluminum alloys is a problem for commercial and military vehicles and aircraft. Paints and other coatings are usually the primary means to prevent the corrosion of automobiles, trucks, and aircraft. Under ideal conditions, the coating provides a continuous layer that is impervious to moisture. At present, maintenance cycles for commercial and military aircraft and ground vehicles is based on experience and appearance rather than a quantitative determination of coating integrity. To improve the maintenance process and reduce costs, sensors are often used to monitor corrosion. The present suite of sensors designed to detect corrosion and marketed to predict the lifetime of the engineered components, however, are not useful for determining the condition of the protective paint coatings. Results from a newly developed sensor to monitor coating condition will be presented and discussed.
Scan Magnification in TV Picture Tubes (1960)

A better utilization of the power dissipated n the scanning system of television picture tubes would represent an advantage for both conventional and transistorized truly portable television receivers.
A hierarchical model of data locality (2006)

In POPL 2002, Petrank and Rawitz showed a universal result---finding optimal data placement is not only NP-hard but also impossible to approximate within a constant factor if P ≠ NP. Here we study a recently published concept called reference affinity, which characterizes a group of data that are always accessed together in computation. On the theoretical side, we give the complexity for finding reference affinity in program traces, using a novel reduction that converts the notion of distance into satisfiability. We also prove that reference affinity automatically captures the hierarchical locality in divide-and-conquer computations including matrix solvers and N-body simulation. The proof establishes formal links between computation patterns in time and locality relations in space.On the practical side, we show that efficient heuristics exist. In particular, we present a sampling method and show that it is more effective than the previously published technique, especially for data that are often but not always accessed together. We show the effect on generated and real traces. These theoretical and empirical results demonstrate that effective data placement is still attainable in general-purpose programs because common (albeit not all) locality patterns can be precisely modeled and efficiently analyzed.
Diastereoselectivity in the osmium tetraoxide promoted dihydroxylation of chiral (E)-crotylsilane: asymmetric synthesis of silyl-functionalized .gamma.-lactones (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiastereoselectivity in the osmium tetraoxide promoted dihydroxylation of chiral (E)-crotylsilane: asymmetric synthesis of silyl-functionalized .gamma.-lactonesJames S. Panek and Jing ZhangCite this: J. Org. Chem. 1993, 58, 2, 294–296Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://doi.org/10.1021/jo00054a002RIGHTS & PERMISSIONSArticle Views263Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (391 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Role of Human Endogenous Retroviral Long Terminal Repeats (LTRs) in Maintaining the Integrity of the Human Germ Line (2011)

Retroviruses integrate a reverse transcribed double stranded DNA copy of their viral genome into the chromosomal DNA of cells they infect. Occasionally, exogenous retroviruses infect germ cells and when this happens a profound shift in the virus host dynamic occurs. Retroviruses maintained as hereditable viral genetic material are referred to as endogenous retroviruses (ERVs). After millions of years of co-evolution with their hosts many human ERVs retain some degree of function and a few have even become symbionts. Thousands of copies of endogenous retrovirus long terminal repeats (LTRs) exist in the human genome. There are approximately 3000 to 4000 copies of the ERV-9 LTRs in the human genome and like other solo LTRs, ERV-9 LTRs can exhibit distinct promoter/enhancer activity in different cell lineages. It has been recently reported that a novel transcript of p63, a primordial member of the p53 family, is under the transcriptional control of an ERV-9 LTR [1]. The expression of different p63 transcript isoforms has been previously shown to have an important role in replenishing cutaneous epithelial stem cells and maintaining the fidelity of the female germ line [2]. In this recent report, a novel p63 transcript, designated GTAp63, is described as specifically expressed in healthy human testes and germ cell precursors of human testes but not in testicular cancer cells. The ability of ERV-9 regulatory regions to contribute to the maintenance of male germ line stability is yet another example of how ERVs have evolved to serve an important function in the physiology of their human hosts.
Contribution of NGR and TNF portions of NGR-TNF to tumor vessel-specific homing and apoptosis in vivo. (2010)

e13554 Background: NGR-TNF is a new peptide-targeted agent coupling CNGRCG peptide (NGR), homing to angiogenic blood vessels, and tumor necrosis factor alpha (TNF), presently in clinical development (phase II studies in MPM, HCC and CRC). Methods: To further elucidate its mechanism of action, we studied NGR-TNF homing and downstream effects with doses comparable to those used in clinical trials. Results: Using NGR-quantum dots in vivo, NGR specifically targets the CD13 expressed in neoangiogenic vessels, sparing CD13+ normal tissues. Using CD13-specific shRNAs we showed that target cell CD13-expression is essential but not sufficient for NGR binding. For the first time, we formally demonstrated the physical interaction between NGR and CD13 by pool-down experiments using NGR-biotinylinated peptides. Although molecular characterization of the NGR-binding complex is still ongoing, microvesicles released by NGR-binding cells are able to transfer the NGR-binding capability to NGR-non-binder cells, suggesting that the binding complex associates on the target cell before NGR engages CD13. The in vivo activity of NGR-TNF may be due to target cell homing determining an increased affinity for TNF receptor (TNFR), and/or to CD13 cell signaling. Our data support the contribution of both mechanisms. First, using a recombinant tagged-human TNF as a probe along with NGR-TNF and TNF as competitors, NGR-TNF has an NGR-mediated higher affinity for TNFR than TNF. Second, in TNF-activated endothelial cells, NGR-TNF inhibits Mek, Erk1/2, and Akt, and activates caspases 3, 8, and 9, resulting in tumor endothelial cells apoptosis in vivo. Of note, these pathways are similarly activated also using NGR and TNF as separate molecules engaging CD13 and TNFR, respectively, indicating that both NGR and TNF portions contribute to the activation of signaling pathways by NGR-TNF. Conclusions: The binding of NGR to CD13 determines not only the “mere homing” of NGR-TNF but also a) the stabilization of the NGR-CD13/TNF-TNFR interaction and b) a direct effect of CD13, leading to a highly selective homing on tumor blood vessels and apoptosis of angiogenic endothelial cells in vivo, thus significantly contributing to the control of tumor growth. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration MolMed MolMed