gebhart/patrepeval huggingface dataset:
A New Instrument for the Continuous Measurement of Condensation Nuclei. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Instrument for the Continuous Measurement of Condensation Nuclei.G. F. SkalaCite this: Anal. Chem. 1963, 35, 6, 702–706Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://pubs.acs.org/doi/10.1021/ac60199a007https://doi.org/10.1021/ac60199a007research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pathogenesis of multiple sclerosis: expression of HERV-Fc1: a human endogenous retrovirus (2011)

healthy controls and from MS patients. We found higher HERV-H/F Gag expression in peripheral blood CD19+ cells and significantly higher expression in monocytes in patients with non-active MS than in healthy controls. For patients with active MS, much higher differences in the HERV-H/F Gag expression relative to healthy controls were detected for CD4+ and CD8+ T cells indicating that this HERV family may play a role in the extensive activation of the innate and adaptive immune responses in MS. Also for patients with active MS, the expression of HERV-H/F Gag by CD4+ T cells was significantly higher than that by CD8a+ T cells. Extracellular HERV-Fc1 RNAs were detected in plasma samples from both healthy controls and from MS patients. In plasma samples from patients with nonactive MS, higher levels of extracellular HERV-Fc1 RNAs were found as compared with healthy controls. Moreover, a 5-fold increase of the amount of extracellular HERV-Fc1 RNA was found in plasma samples from patients with active MS as compared with healthy controls.
Microbially Mediated Immobilization of Contaminants Through In Situ Biostimulation: Scale up of EMSP project 55267 (2004)

The overall goal of the proposed research is to provide an improved understanding and predictive capability of the mechanisms that allow metal-reducing bacteria to be effective in the bioremediation of redox sensitive toxic metals and radionuclides. The study is motivated by the likelihood that subsurface metal-reducing bacteria can be stimulated to effectively alter the redox state of contaminants so that they are immobilized in situ for long time periods. The work described in this proposal will advance the technological and scientific needs associated with the long-term management of the enormous inground inventories of Cr, U, Tc, and Co present at numerous DOE installations throughout the country. The objectives of our project are to (1) develop an improved understanding and predictive capability of the rates and mechanisms controlling microbially mediated reduction of toxic metals and radionuclides in heterogeneous field settings, (2) quantify the impacts of hydrological and geochemical processes on the effectiveness of indigenous microorganisms to transform and immobilize radionuclides and metals in situ, (3) provide an improved understanding of the importance of microbial consortia interactions in the bacterial immobilization of radionuclides and toxic metals, and (4) determine intrinsic bioreduction rate parameters to improve our generic predictive capability of in situ microbially mediated metal reduction. This report summarizes 3.5 y of research for a 4.5 y project.
Abstract 3143: A functional interaction between alpha-fetoprotein and miRNA-29 modulates the HCC epigenome. (2013)

Abstract Globally, hepatocellular carcinoma (HCC) accounts for 70-85% of primary liver cancers and ranks second in the leading cause of male cancer death. Serum alpha-fetoprotein (AFP), normally expressed during fetal development, is reactivated in 60% of HCC tumors and associated with poor patient outcome. We hypothesize that AFP+ and AFP- tumors may differ biologically and have different prognosis in HCC patients. Using microarray-based global microRNA and mRNA profiling, we found that members of the miR-29 family are the most significantly (p&lt;1E-5) down-regulated miRs in AFP+ tumors (n=242). Physiologically, during mouse embryonic development, miR-29 family expression is low but gradually increases after birth, contrary to AFP expression which dramatically decreases after birth. In addition, a member of the DNA methyltransferase (DNMT) family, DNMT3A, is one of the most significantly (p=8E-6) up-regulated genes in AFP+ HCC. Interestingly, there is a significant inverse correlation (p&lt;1E-4) between miR-29 and DNMT gene expression, suggesting that they may be functionally antagonistic, which is consistent with the finding showing that DNMT3A and DNMT3B are direct targets of miR-29. Experimentally, we found that increased AFP expression or the addition of AFP+ media to AFP- cells inhibits miR-29a expression in HCC cell lines. We also found that AFP transcriptionally regulates the promoter of miR-29a. Moreover, global DNA methylation array profiling reveals increased methylation in HCC patients with high levels of serum AFP. These results support our hypothesis that AFP inhibits miR-29, which modulates epigenetic changes that contribute to poor outcome. Taken together, this study elucidates the mechanisms that link AFP and miR-29 expression to epigenetic alterations and may aid in the development of novel therapeutic agents to improve survival of HCC patients. Citation Format: Sonya Parpart, Stephanie Roessler, Fei Dong, Vinay Rao, Christopher Loffredo, Xin Wei Wang. A functional interaction between alpha-fetoprotein and miRNA-29 modulates the HCC epigenome. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3143. doi:10.1158/1538-7445.AM2013-3143
Generic coder for binarysources: the M-coder (1995)

A new entropy coder, the M-coder, based on the classical TRL code, is proposed. Unlike the ATRL coder, which is blockwise adaptive, the M-coder is a bit by bit adaptive coder. To accomplish this, the M-coder requires a probability estimation scheme for the symbols to be coded. In this way, the M-coder can be compared to the Q-coder, with an easier implementation.
Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein–Protein Interaction (2016)

The interaction between the cell-cell adhesion proteins CD2 and CD58 plays a crucial role in lymphocyte recruitment to inflammatory sites, and inhibitors of this interaction have potential as immunomodulatory drugs in autoimmune diseases. Peptides from the CD2 adhesion domain were designed to inhibit CD2:CD58 interactions. To improve the stability of the peptides, β-sheet epitopes from the CD2 region implicated in CD58 recognition were grafted into the cyclic peptide frameworks of sunflower trypsin inhibitor and rhesus theta defensin. The designed multicyclic peptides were evaluated for their ability to modulate cell-cell interactions in three different cell adhesion assays, with one candidate, SFTI-a, showing potent activity in the nanomolar range (IC50: 51 nM). This peptide also suppresses the immune responses in T cells obtained from mice that exhibit the autoimmune disease rheumatoid arthritis. SFTI-a was resistant to thermal denaturation, as judged by circular dichroism spectroscopy and mass spectrometry, and had a half-life of ∼24 h in human serum. Binding of this peptide to CD58 was predicted by molecular docking studies and experimentally confirmed by surface plasmon resonance experiments. Our results suggest that cyclic peptides from natural sources are promising scaffolds for modulating protein-protein interactions that are typically difficult to target with small-molecule compounds.
Field quality evaluation of the superconducting magnets of the Relativistic Heavy Ion Collider (2002)

In this paper, we first present the procedure established to evaluate the field quality, quench performance, and alignment of the superconducting magnets manufactured for the Relativistic Heavy Ion Collider (RHIC), and then discuss the strategies used to improve the field quality and to minimize undesirable effects by sorting the magnets. The field quality of the various RHIC magnets is briefly summarized.
A Footstep-plan-based Floor Sensing Method Using Stereo Images for Stable Slope Walking of Biped Robot (2010)

It is important for autonomous control of a biped robot to obtain the 3D information of the ground on which the robot walks. When a biped robot traverses a floor including slopes, sensors should be able to detect a slope and precisely measure the angle of the slope, along with the positions of its beginning and end. In this paper, we propose a realtime floor sensing method using stereo cameras mounted on a biped robot. We detect a slope in the environment and estimate the inclination angle and the boundary by fitting a set of plane parameter vectors to a two-plane model. For obtaining the parameter vector set, we first determine multiple regions of interest (ROI) in a reference image by using footstep positions up to several steps, scheduled by a current footstep plan. Then the parameter vector of the floor with respect to each ROI are efficiently and accurately estimated by a fast direct method with motion compensation. The fitting result is feedback for stable walking by updating the footstep plan . The validity of the proposed method is demonstrated through online experiments using stereo cameras mounted on the body of a biped robot, Honda ASIMO, traversing a real slope.
Laser cooling by 65 K of Yb/sup 3+/-doped ZBLANP glass (2000)

Summary form only given. Anti-Stokes photoluminescence cooling of a Yb/sup 3+/-doped ZBLANP optical fiber has been accomplished by optical pumping at 1015 nm. The temperature drop, as determined by temperature-dependent changes in the fluorescence spectrum, is 65 K.
Recent Advances in Ophthalmology. (1929)

This work is given its deserved place by all students of ophthalmology as a supplement to the standard texts. The readers will welcome the author's service in gathering 370 additional references, and in increasing the volume of the text by about one-fourth, all accomplished in the short space of two years since the appearance of the first edition. There is no doubt that one of the best "advances" in recent years in the field of ophthalmology is this little book in its several editions. As never before, the busy ophthalmologist can follow the productive research work from the earth's four corners in a coherent and intelligent fashion in the time that he has for his reading. The present edition goes a little further than its predecessor into the nature of light, and the transmission and absorption of light by the media of the eye. One notes with interest the
Researches in loudness measurement (1966)

CBS Laboratories has performed a fundamental study of loudness from which several results already have emerged. A new set of equal-loudness contours has been obtained using octave bands of "pink" noise in a simulated living room environment. The CBS Laboratories contours differ radically from the Fletcher-Munson contours. Forward vs. backward inhibition tests were performed, from which a new summation function was deduced. A new duration vs. loudness level function was obtained for octave bands ranging in frequency from 125 Hz to 8 kHz. These data are being incorporated in an instrument for measuring sensory loudness level.
Accurate analysis and optimization of whisker-contacted Schottky-diode frequency doublers (2002)

A 300 GHz frequency doubler with a standard crossed-waveguide design has been investigated. The embedding impedance at both fundamental and second harmonic frequency has been optimized to the desired diode impedance by a commercial finite element program. Preliminary measurements are in good agreement with the expected multiplier performance.
Rapid quantification of stroke volume using magnetohydrodynamic voltages in 3T MRI: a feasibility study (2015)

Background The Electrocardiogram (ECG) is a standard clinical tool for cardiac physiological monitoring, required for cardiac synchronization during cardiac MRI, despite signal artifacts resulting from Magnetohydrodynamic voltages (VMHD). VMHD becomes significant during systole when rapidly ejected blood from the left ventricle into the aortic arch interacts with the strong magnetic field (B0 )o f the MRI [1]. Due to this relationship, we hypothesized that blood flow as a function of time in the cardiac cycle and left ventricular Stroke Volume (SV) could be derived using VMHD extracted from intra-MRI ECG. This method would allow for real-time beat-to-beat SV estimation during clinical MR scanning and cardiac MRI stress testing. This non-invasive real-time physiological measure of patient condition can be provided with the described software processing during conventional cardiac MRI routines, and potentially replace Invasive Blood Pressure during complex interventional procedures.
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition (2017)

KCC2 is a neuron-specific K<sup>+</sup>-Cl<sup>-</sup> cotransporter essential for establishing the Cl<sup>-</sup> gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis and AMPA receptor confinement. Aberrant KCC2 function contributes to human neurological disorders including epilepsy and neuropathic pain. Using functional proteomics, we identified the KCC2-interactome in the mouse brain to determine KCC2-protein interactions that regulate KCC2 function. Our analysis revealed that KCC2 interacts with diverse proteins, and its most predominant interactors play important roles in postsynaptic receptor recycling. The most abundant KCC2 interactor is a neuronal endocytic regulatory protein termed PACSIN1 (SYNDAPIN1). We verified the PACSIN1-KCC2 interaction biochemically and demonstrated that shRNA knockdown of PACSIN1 in hippocampal neurons increases KCC2 expression and hyperpolarizes the reversal potential for Cl<sup>-</sup>. Overall, our global native-KCC2 interactome and subsequent characterization revealed PACSIN1 as a novel and potent negative regulator of KCC2.
<i>Vestigial</i> and <i>scalloped</i> in the ladybird beetle: a conserved function in wing development and a novel function in pupal ecdysis (2009)

In Drosophila melanogaster, Vestigial (Vg) and Scalloped (Sd) form a transcription factor complex and play a crucial role in wing development. To extend our knowledge of insect wing formation, we isolated vg and sd homologues from two ladybird beetle species, Henosepilachna vigintioctopunctata and Harmonia axyridis. Although the ladybird beetle vg homologues had only low homology with D. melanogaster vg, ectopic expression of H. vigintioctopunctata vg induced wing-like tissues in antennae and legs of D. melanogaster. Subsequent larval RNA interference (RNAi) analysis in H. vigintioctopunctata demonstrated conserved functions of vg and sd in wing development, and an unexpected novel function of sd in pupal ecdysis. Furthermore, our results can be applied to the production of a flightless ladybird beetle for biological control purposes using larval RNAi.
The Guide Language (1994)

The Guide language is an object-oriented language dedicated for programming distributed applications on top of the Comandos platform. This language faithfully reflects all the capabilities of the Comandos model. It combines the facilities of a strongly typed object model with a powerful computational model. Key features of the language are: separation between types and classes, conformant subtyping, distribution transparency, concurrent activities, synchronization mechanism for shared objects, and exception handling. This paper presents the design choices for the Guide language and discusses programming experience gained from the use of the language for the construction of distributed applications.
Polyepiiodohydrin (1978)

Abstract Polyepiiodohydrin was prepared from polyepichlorohydrin by the Finkelstein reaction with sodium iodide in butanone. An 88% degree of replacement of chlorine by iodine was obtained. The reaction of iodides with polyepichlorohydrin was accompanied by a substantial drop in molecular weight. The copolymer, which contains eight epiiodohydrin units per epichlorohydrin unit, has a glass transition temperature of 1°C and a density of 2.2 g/cm 3 . Properties of epiiodohydrin homopolymer were estimated by extrapolation of copolymer data.
Thermoreversible Gelation of Solutions of Syndiotactic Poly(methyl methacrylate) in Toluene: a Two-Step Mechanism (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermoreversible Gelation of Solutions of Syndiotactic Poly(methyl methacrylate) in Toluene: a Two-Step MechanismM. Berghmans, S. Thijs, M. Cornette, H. Berghmans, F. C. De Schryver, P. Moldenaers, and J. MewisCite this: Macromolecules 1994, 27, 26, 7669–7676Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ma00104a023https://doi.org/10.1021/ma00104a023research-articleACS PublicationsRequest reuse permissionsArticle Views280Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
4-Phenylalanine analogues of vasopressin: Synthesis, pharmacological and chiroptical properties (1986)

Synthesis, some pharmacological properties and CD spectra of [4-phenylalanine, 8-arginine]vasopressin and [4-phenylalanine, 8-lysine]vasopressin are described.
Modulatory Effects of Plant Polyphenols on Bone Remodeling: A Prospective View From the Bench to Bedside (2019)

During the past, a more comprehensive knowledge of mechanisms implicated in bone resorption processes has driven researchers to develop a compound library of many small molecules that specifically interfere with the genesis of osteoclast precursors cells. Natural compounds that suppress osteoclast commitment may have therapeutic value in treating pathologies associated with bone resorption like osteoporosis, rheumatoid arthritis, bone metastasis, and periodontal disease. The present review is focused on the current knowledge on the polyphenols derived from plants that could be efficacious in suppressing osteoclast differentiation and bone resorption.
Hydrodenitrogenation of coal tar pitch. (Part 4). Catalyst deactivation and analysis of used catalyst. (1988)

コールタールピッチの水素化脱窒素における触媒劣化に関して, 反応条件の影響と使用済み触媒の分析に注目し検討した。触媒には炭素質およびナトリウム等の金属質がたい積し, そのため細孔容積と表面積は減少する。触媒劣化は炭素質および金属質のたい積に起因すると考えられ, 運転初期においては炭素質の急激なたい積によるものが支配的で大きく劣化し, それ以降はナトリウム等の金属質のたい積が支配的となり徐々に劣化すると思われる。また長期運転における触媒劣化は触媒層平均のナトリウムたい積量を用いると統一的に表すことができる。
ChemInform Abstract: 2‐((2‐Aminobenzyl)sulfinyl)‐1‐(2‐pyridyl)‐1,4,5,6‐tetrahydrocyclopent( d)imidazoles as a Novel Class of Gastric H+/K+‐ATPase Inhibitors. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sequence specific damage of DNA induced by reducing sugars (1985)

Reducing sugars induced alkali-labile sites in DNA. The DNA reacted with D-fructose 6-phosphate or D-fructose in the presence of Cu2+ was cleaved by the treatment with aqueous piperidine at 90 degrees C for 30 min. Alkali-labile sites were induced frequently at the pyrimidine residues, especially at the pyrimidine residues in pyrimidine-purine (5'----3') sequences. Transition metal ions such as Cu2+ and oxygen radicals such as hydrogen peroxide were possibly involved in the induction of alkali-labile sites.
Index of refraction of doped BaTiO<sub>3</sub>crystals (1990)

Abstract The indices of refraction in the cubic phase of a crystal of BaTiO3 doped with Fe, and one doped with Mn, as well as (Ba0.56Sr0.44)TiO3 are reported and compared to that of pure BaTiO3. In all cases similar precursor effects are seen approximately 100°C above Tc. Thus, this effect seems to be an intrinsic property of BaTiO3, and not directly caused by impurities. The connection of these effects to overdamped phonons is discussed.
Volatile products formed from the thermal degradation of thiamin at high and low moisture levels (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVolatile products formed from the thermal degradation of thiamin at high and low moisture levelsGuy J. Hartman, James T. Carlin, Juergen D. Scheide, and Chi Tang HoCite this: J. Agric. Food Chem. 1984, 32, 5, 1015–1018Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/jf00125a016https://doi.org/10.1021/jf00125a016research-articleACS PublicationsRequest reuse permissionsArticle Views393Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of Implantable Glucose Enzyme-Based Sensors with Extracorporal Blood Shunt (1988)

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