gebhart/patrepeval huggingface dataset:
Recent Improvements in the ATLAS PanDA Pilot (2012)

The Production and Distributed Analysis system (PanDA) in the ATLAS experiment uses pilots to execute submitted jobs on the worker nodes. The pilots are designed to deal with different runtime conditions and failure scenarios, and support many storage systems. This talk will give a brief overview of the PanDA pilot system and will present major features and recent improvements including CernVM File System integration, the job retry mechanism, advanced job monitoring including JEM technology, and validation of new pilot code using the HammerCloud stress-testing system. PanDA is used for all ATLAS distributed production and is the primary system for distributed analysis. It is currently used at over 100 sites world-wide. We analyze the performance of the pilot system in processing LHC data on the OSG, EGI and Nordugrid infrastructures used by ATLAS, and describe plans for its further evolution.
Usability of therapy controllers in elderly patients with deep brain stimulation (2012)

Technical devices are becoming more prevalent in society and also in medical care. Older adults need more support to learn new technologies than younger subjects. So far, no research has been done on the usability of patient controllers in deep brain stimulation in an elderly population. The aim of the study was to investigate the factors influencing the performance of elderly DBS patients with respect to usability aspects of Medtronic Access therapy controllers. Time, mistakes and frequency of use of the controller were compared in 41 elderly DBS patients who prior to the study had already owned a therapy controller for more than six years. One group (n = 20, mean age = 66.4 years) was watching an instructional video and then completed practical assignments on a model implantable pulse generator (IPG). The other group (n = 21, mean age = 65.9 years) completed the tasks without having seen the video before. Any errors that patients made were documented and also corrected so that all of them received hands-on training. After six months all patients were re-evaluated on the dummy IPG in order to compare the effects of hands-on alone vs. video-based training combined with hands-on. The group that had seen the video before significantly outperformed the control group at both assessments with respect to number of errors. Both groups performed faster after six months compared to baseline and tend to use the controller more often than at baseline. Our results indicate that elderly DBS patients who have been using the controller for several years still have various difficulties in operating the device. However, we also showed that age-specific training may improve the performance in older adults. In general, the design of DBS patient controllers should focus on the specific needs of the end-users. But as changes to medical devices take a long time to be implemented, video instructions with age-specific content plus hands-on training may improve learning for older adults.
A time-division multiplexed tactile vision substitution system (1984)

We have developed a computer-controlled tactile vision substitution system which maximizes use of the skin's ability to process spatial and temporal information. The system receives a 128-column X 64-row image from a commercially available digital camera. An IBM personal computer sections the image into a controllable number of 6 X 24 blocks. The computer then sequentially sends these blocks to the 6 X 24 vibratory fingertip stimulation matrix on an Optacon reading device for the blind. Custom hardware provides the interface between the IBM PC and the Optacon. The image manipulation software is written in Intel 8088 assembly code.
Primary cutaneous nocardiosis with multiple, subcutaneous abscesses in a patient with sarcoidosis (2002)

A case of multiple subcutaneous nocardial abscesses is reported in a patient who received systemic corticosteroids over a period of about 4 years for the treatment of visceral sarcoidosis. The diagnosis of subcutaneous abscess caused by Nocardia asteroides was made based on bacteriological examination. It could not be determined before treatment whether the abscesses represented primary or secondary nocardiosis. Surgical drainage and systemic administration of minocycline hydrochloride dramatically resolved the cutaneous lesions. To the authors' knowledge, this is the first reported case in Japan of primary cutaneous nocardiosis in a patient with sarcoidosis.
Binding of hydroxylamine to the water-oxidizing complex and the ferroquinone electron acceptor of spinach photosystem II (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of hydroxylamine to the water-oxidizing complex and the ferroquinone electron acceptor of spinach photosystem IIM. Sivaraja and G. C. DismukesCite this: Biochemistry 1988, 27, 9, 3467–3475Publication Date (Print):May 3, 1988Publication History Published online1 May 2002Published inissue 3 May 1988https://pubs.acs.org/doi/10.1021/bi00409a051https://doi.org/10.1021/bi00409a051research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: SYNTHESIS, STRUCTURE, AND REACTIONS OF PRIMARY ADDUCTS FROM SULFUR OR SELENIUM AND HEXAPHENYLCARBODIPHOSPHORANE (1982)

Abstract Carbodiphosphorane wie (I) ergeben bei der Umsetzung mit Schwefel als Folgeprodukte Phosphacumulenylide.
Surgery of vertebrobasilar aneurysms and nimodipine. (1986)

Five patients among 60 consecutive patients suffering from recent subarachnoid hemorrhage were operated for ruptured vertebrobasilar aneurysm. Topical nimodipine treatment was given during the operation after clipping and continued systemically for three weeks. One out of the five patients developed symptoms which could be ascribed to delayed arterial vasospasm. Nimodipine may be advantageous in preventing ischemic complications when used prophylactically. Further investigation is needed to elucidate its efficacy in cases of vertebrobasilar aneurysms and conventional timing of surgery.
Two-Dimensional Covalent Crystals by Chemical Conversion of Thin van der Waals Materials (2019)

Most of the studied two-dimensional (2D) materials have been obtained by exfoliation of van der Waals crystals. Recently, there has been growing interest in fabricating synthetic 2D crystals which have no layered bulk analogues. These efforts have been focused mainly on the surface growth of molecules in high vacuum. Here, we report an approach to making 2D crystals of covalent solids by chemical conversion of van der Waals layers. As an example, we used 2D indium selenide (InSe) obtained by exfoliation and converted it by direct fluorination into indium fluoride (InF<sub>3</sub>), which has a nonlayered, rhombohedral structure and therefore cannot possibly be obtained by exfoliation. The conversion of InSe into InF<sub>3</sub> is found to be feasible for thicknesses down to three layers of InSe, and the obtained stable InF<sub>3</sub> layers are doped with selenium. We study this new 2D material by optical, electron transport, and Raman measurements and show that it is a semiconductor with a direct bandgap of 2.2 eV, exhibiting high optical transparency across the visible and infrared spectral ranges. We also demonstrate the scalability of our approach by chemical conversion of large-area, thin InSe laminates obtained by liquid exfoliation, into InF<sub>3</sub> films. The concept of chemical conversion of cleavable thin van der Waals crystals into covalently bonded noncleavable ones opens exciting prospects for synthesizing a wide variety of novel atomically thin covalent crystals.
Genetic Markers Associated with Cutaneous Adverse Drug Reactions to Allopurinol: A Systematic Review (2015)

Pharmacogenomic markers in the HLA coding genes have been associated with drug hypersensitivity of multiple drugs, including allopurinol. In this systematic review, we summarize the pharmacogenomic evidence available regarding allopurinol-induced cutaneous adverse drug reactions (cADRs). We found that the HLA-B*5801 allele was significantly associated with the risk of severe cADRs in the Han Chinese, Korean, Thai, Japanese and European populations. The association between less severe cADRs and HLA-B*5801 was less consistent. All SNPs identified in genome-wide association studies of common variants were also located in or nearby HLA-B*5801. Future studies should focus on more common but less severe allopurinol-induced cADRs, as well as the potential role of rare variants as predictors of these cADRs.
Growth Characteristics, Grain Filling, and Assimilate Transport in a Shrunken Endosperm Mutant of Barley (1983)

The reported inheritance pattern of the seg1 shrunken endosperm mutant of barley (Hordeum vulgare L. cv Betzes) suggests that some defective process in the maternal plant tissues, and not in the endosperm, prevents normal grain filling in the mutant. To identify the physiological mechanism of the mutation, we compared growth, carbon exchange, and assimilate transport of Betzes and seg1 plants. Betzes and seg1 plants did not differ in mean relative growth rate, mean net assimilation rate, or carbon exchange rate. The rate and duration of grain growth of seg1 was lower than Betzes on intact plants and on detached, cultured spikes. Increasing the supply of sucrose in culture media up to 300 mm sucrose did not eliminate differences between normal and mutant grain growth. Translocation of (14)C-labeled assimilates into seg1 grains ceased by 21 days after anthesis, and assimilates were diverted to lower plant parts. In contrast, assimilates were still entering Betzes grains at 29 days after anthesis. Evidence suggests that some maternal spike or grain tissue is affected by the mutation after the onset of grain filling. Identification of the specific seg1 defect may provide information about the cessation of normal grain filling.
Hydrogenated Anatase: Strong Photocatalytic Dihydrogen Evolution without the Use of a Co‐Catalyst (2014)

Abstract The high‐pressure hydrogenation of commercially available anatase or anatase/rutile TiO 2 powder can create a photocatalyst for H 2 evolution that is highly effective and stable without the need for any additional co‐catalyst. This activation effect cannot be observed for rutile; however, for anatase/rutile mixtures, a strong synergistic effect can be found (similar to results commonly observed for noble‐metal‐decorated TiO 2 ). EPR and PL measurements indicated the intrinsic co‐catalytic activation of anatase TiO 2 to be due to specific defect centers formed during hydrogenation. These active centers can be observed specifically for high‐pressure hydrogenation; other common reduction treatments do not result in this effect.
Immune Thrombocytopenia Treated with High-Dose Intravenous Gamma Globulin and Corticosteroids in Two Patients with Wiskott-Aldrich Syndrome (1988)

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disorder characterized by thrombocytopenia, atopic dermatitis, and susceptibility to recurrent infections. The thrombocytopenia, due to an intrinsic platelet defect, is only rarely complicated by immune thrombocytopenia (ITP). We report two patients with WAS in whom ITP complicated their thrombocytopenia. In addition, immune neutropenia accompanied the ITP in one patient. Whereas administration of high-dose intravenous gamma globulin (IGIV) alone did not ameliorate the ITP, corticosteroids did improve the ITP and immune neutropenia. High-dose IGIV appeared to be synergistic with corticosteroids and thus have a steroid-sparing effect.
Guianolides A and B, New Carbon Skeletal Limonoids from the Seeds of <i>Carapa guianensis</i> (2013)

Two novel limonoids, named guianolides A (1) and B (2), were isolated from the seeds of Carapa guianensis AUBLET (Meliaceae). Their structures were established by spectroscopic analyses and X-ray crystallography. Guianolides A (1) and B (2) featured an unprecedented carbon skeleton via the formation of a C-11-C-21 bond.
Fetal Growth Restriction Results in Remodeled and Less Efficient Hearts in Children (2010)

These findings suggest that FGR induces primary cardiac and vascular changes that could explain the increased predisposition to cardiovascular disease in adult life. If these results are confirmed, the impact of strategies with beneficial effects on cardiac remodeling should be explored in children with FGR.
Long-lived states to sustain hyperpolarized magnetization (2009)

Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization (DNP) couples nuclear spins to the large reservoir of electrons, thus making it possible to detect dilute endogenous substances in magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI). We have designed a method to preserve enhanced ("hyperpolarized") magnetization by conversion into long-lived states (LLS). It is shown that these enhanced long-lived states can be generated for proton spins, which afford sensitive detection. Even in complex molecules such as peptides, long-lived proton states can be sustained effectively over time intervals on the order of tens of seconds, thus allowing hyperpolarized substrates to reach target areas and affording access to slow metabolic pathways. The natural abundance carbon-13 polarization has been enhanced ex situ by almost four orders of magnitude in the dipeptide Ala-Gly. The sample was transferred by the dissolution process to a high-resolution magnet where the carbon-13 polarization was converted into a long-lived state associated with a pair of protons. In Ala-Gly, the lifetime T(LLS) associated with the two nonequivalent H(alpha) glycine protons, sustained by suitable radio-frequency irradiation, was found to be seven times longer than their spin-lattice relaxation time constant (T(LLS)/T(1) = 7). At desired intervals, small fractions of the populations of long-lived states were converted into observable magnetization. This opens the way to observing slow chemical reactions and slow transport phenomena such as diffusion by enhanced magnetic resonance.
Trastuzumab resistance: Bringing tailored therapy to the clinic (2008)

SCOPUS: re.j
Triple Therapy in Cadaveric Renal Transplantation: Role of Induction Cyclosporine and Targeted Levels to Avoid Rejection (1995)

The updated data on 61 consecutive cadaveric transplants performed at our institution from 1987 to 1990 (followup 31 to 82 months, median 54 months) were analyzed with emphasis on cyclosporine monitoring and long-term results. All patients received triple therapy with cyclosporine induction, azathioprine and prednisone regardless of graft function, and they were preferentially placed on the calcium blocker nifedipine. We monitored 12-hour cyclosporine trough levels in whole blood using high performance liquid chromatography and the dose was adjusted to maintain levels at 150 ng./ml. or greater for the first 3 months. In 17 of 61 patients (28%) 22 rejection episodes occurred and 20 nephrotoxicity episodes occurred in 17 of 61 patients (28%). There was no significant difference in the mean cyclosporine levels among 32 rejection, nonrejection, nephrotoxic and nonnephrotoxic cases at any interval. Rejection occurred by 1 month in 13 (76%) and by 3 months in 15 (88%) of 17 patients. Comparisons were made in the first month to define the desirable cyclosporine levels by calculating the mean cyclosporine only within 10 to 14 days of rejection or nephrotoxicity events. The mean cyclosporine level before rejection was significantly lower than that for nephrotoxicity (188 +/- 113 versus 304 +/- 62 ng./ml., p < 0.01). The median cyclosporine level for first month rejection was also significantly lower than that for nonrejection (156 versus 218 ng./ml., p < 0.05) and it was significantly greater for nephrotoxicity versus nonnephrotoxicity (272 versus 218 ng./ml., p < 0.05). Of 13 rejections in the first month 10 (77%) were associated with mean levels of less than 210 ng./ml. Actuarial graft survival at 1, 3 and 5 years was 93.4%, 87.8% and 78.5%, respectively. The 3-year graft survival was significantly worse for patients who experienced acute rejection episodes versus those who did not (68.8% versus 96.7%, p < 0.05) but it was not different for nephrotoxic versus nonnephrotoxic groups (85.6% versus 79.6%). Long-term function was not influenced by the occurrence of acute nephrotoxicity events. These findings confirm the efficacy of triple therapy with induction cyclosporine in cadaveric transplantation, yielding improved short-term and intermediate graft survival without any adverse effects on long-term graft function. Specific cyclosporine level monitoring is invaluable, particularly initially, with high target levels of 200 ng./ml. or greater. The use of calcium blockers may have allowed higher cyclosporine dosing in the first 3 months, mitigating against cyclosporine associated chronic nephrotoxicity.
Effect of emitter thickness on the spectral shape of heterojunction interfacial workfunction internal photoemission detectors (2009)

Results are presented showing the effect of emitter layer thickness on the shape of the spectral response of heterojunction interfacial workfunction internal photoemission detectors. The results confirm that thicker emitters increase the response at shorter wavelengths. A model is developed to explain the experimentally observed blueshift in the peak wavelength with increased emitter thickness, using a combination of hot-cold carrier scattering and phonon emission processes. The study provides a tool for designing detectors exhibiting different peak responses, as demonstrated by evaluating the design parameters for the 8–14μm spectral range.
Effect of Zeta Potential of Exfoliated Amphiphilic Montmorillonite Nanogels on Removal Efficiencies of Cationic Dye water pollutant (2016)

The zeta or electrokinetic potential describes the nanomaterials potential distribution and it is often a useful parameter to evaluate the adsorption of ionic pollutants on the nanomaterials surfaces, since it reflects the electrostatic interactions of water pollutants on the nanomaterials surfaces. In this respect, sodium montmorillonite (Na-MM) attracted great attention in the removal of toxic pollutants from water. The present work aims to increase the ability of MMT to act as amphiphiles to increase the diffusion of pollutants into MMT galleries. The exchange of Na cations with a cationic monomer based on 3-acrylamidopropyl trimethylammonium chloride followed by crosslinking copolymerization achieves this goal. Therefore, different MMT copolymer nanogels based on APTAC were prepared using anionic and nonionic co-monomers and characterized by FTIR, TEM, WXD, and zeta potential analyses. The surface activity of the amphiphilic MMT nanogels was evaluated from the surface tension measurements. The adsorption of MB on the surface of Na-MMT was studied at different MMT nanogel concentrations, and pH through zeta potential measurements. The removal efficiencies of MMT nanogels for removing methylene blue as cationic dye from water were measured at room temperature and pH 7. The data indicated that the removal efficiencies of MMT nanogels increased by complete exfoliation of MMT layers and their high surface activity that increased the MB penetration into the network of MMT nanogel.
Social media in public health (2013)

Further work is needed on social media as a valid data source for detecting or predicting diseases or conditions. Also, whether or not it is an effective tool for communicating key public health messages and engaging both, the general public and policy-makers.
Tetrakis(tri‐<i>tert</i>‐butylsilyl)‐<i>tetrahedro</i>‐tetragerman (<i>t</i>Bu<sub>3</sub>Si)<sub>4</sub>Ge<sub>4</sub> ‐ die erste molekulare Germaniumverbindung mit einem Ge<sub>4</sub>‐Tetraeder (1996)

Tiefrot, oxidations‐ und hydrolyseempfindlich ist das erste Derivat des tetrahedro ‐Tetragermans Ge 4 H 4 , die Titelverbindung 1 . Sie wurde gemäß Gleichung (a) hergestellt und in Form von 2 ( t Bu 3 Si) 4 Ge 4 · ( t Bu 3 Si) 2 kristallin isoliert und charakterisiert. In diesen Kristallen sind die t Bu 3 Si‐Gruppen von 1 ‐vermutlich infolge von Wechselwirkungen mit den ( t Bu 3 Si) 2 ‐Molekülen – nicht radialsymmetrisch um das Ge 4 ‐Tetraeder angeordnet, sondern leicht abgeknickt. magnified image
Decarboxylation of 6-Nitrobenzisoxazole - 3 - Carboxylic Acid Through Phase Transitions in Lyotropic Liquid Crystals (1997)

Abstract Kinetics of the spontaneous decarboxylation of 6-nitrobenzisoxazole-3-carboxylic acid have been studied in the lyophases formed by anionic, cationic and nonionic surfactants: sodium dodecyl sulfate (SDS), myristyltrimethylammonium bromide (MTAB) and pentaethylene glycol mono-n-dodecylether (C12E5) respectively. This substrate was chosen for study because of the large amount of data available on its behavior in micellar solution. Without surfactants the reaction proceeds slowly in both acidic (pH 4.0) and alkaline (pH 9.0-11.0) water solutions, with the reaction rate ∼0.7×10−5 S−1 (at 25 °C). Anionic SDS has no catalyzing effect on the reaction. Cationic MTAB siguiimtiy accelerates the reaction in all phases: isotropic, lamellar or cylindrical nematic. Nonionic C12E5 is the only surfactant which shows a catalyzing effect dependent on the type of the lyophase. The reaction goes ∼1.5 times faster in the lamellar as compared to the isotropic phase.
Regulation of Alternative Splicing of CD45 by Antagonistic Effects of SR Protein Splicing Factors (2000)

CD45 is a transmembrane glycoprotein possessing tyrosine phosphatase activity, which is involved in cell signaling. CD45 is expressed on the surface of most leukocytes and can be alternatively spliced by the inclusion or skipping of three variable exons (4, 5, and 6 or A, B, and C) to produce up to eight isoforms. In T cells, the splicing pattern of CD45 isoforms changes after activation; naive cells express high m.w. isoforms of CD45 which predominantly express exon A (CD45RA), whereas activated cells lose expression of exon A to form low m.w. isoforms of CD45 including CD45RO. Little is known about the specific factors controlling the switch in CD45 splicing which occurs on activation. In this study, we examined the influence of the SR family of splicing factors, which, like CD45, are expressed in tissue-specific patterns and have been shown to modulate the alternative splicing of a variety of transcripts. We show that specific SR proteins have antagonistic effects on CD45 splicing, leading either to exon inclusion or skipping. Furthermore, we were able to demonstrate specific changes in the SR protein expression pattern during T cell activation.