gebhart/patrepeval huggingface dataset:
Calcium/Calmodulin Dependent Protein Kinase II Bound to NMDA Receptor 2B Subunit Exhibits Increased ATP Affinity and Attenuated Dephosphorylation (2011)

Calcium/calmodulin dependent protein kinase II (CaMKII) is implicated to play a key role in learning and memory. NR2B subunit of N-methyl-D-aspartate receptor (NMDAR) is a high affinity binding partner of CaMKII at the postsynaptic membrane. NR2B binds to the T-site of CaMKII and modulates its catalysis. By direct measurement using isothermal titration calorimetry (ITC), we show that NR2B binding causes about 11 fold increase in the affinity of CaMKII for ATPγS, an analogue of ATP. ITC data is also consistent with an ordered binding mechanism for CaMKII with ATP binding the catalytic site first followed by peptide substrate. We also show that dephosphorylation of phospho-Thr(286)-α-CaMKII is attenuated when NR2B is bound to CaMKII. This favors the persistence of Thr(286) autophosphorylated state of CaMKII in a CaMKII/phosphatase conjugate system in vitro. Overall our data indicate that the NR2B- bound state of CaMKII attains unique biochemical properties which could help in the efficient functioning of the proposed molecular switch supporting synaptic memory.
A behavioral simulation tool for continuous-time delta-sigma modulators (2002)

Circuit–level simulation of 16 modulators is a time– consuming task (taking one or more days for meaningful results). While there are a great variety of techniques and tools that speed up the simulations for discrete–time (DT)16 modulators, there is no rigorous methodology implemented in a tool to efficiently simulate and design the continuous– time (CT) counterpart. Yet, in todays low–power, high–accuracy and/or very high–speed demands for A–to–D converters, designers are often forced to resort to the use of CT 16 topologies. In this paper, we present a method for the high–level simulation of continuous–time 16 modulators that is based on behavioral models and which exhibits the best trade–off between accuracy, speed and extensibility compared to other possible techniques that are reviewed briefly in this work. A user–friendly tool, implementing this methodology, is then presented. Nonidealities such as finite gain, finite GBW, output impedance and also nonlinearities such as clipping, harmonic distortion and the important effect of jitter are modeled. Finally, experiments were carried out using the tool, exploring important design trade–offs.
Exercise and Childrenʼs Health (2002)

Every child and adolescent needs exercise, which is a risk-free investment for current and future health. Physicians can help parents and children understand the importance of exercise and help them select safe, enjoyable, age-appropriate activities. This article discusses current literature regarding exercise and its effects on children's health, including nutrition and cardiovascular issues. It also reviews the epidemiology and treatment of injuries in young athletes, including preventative measures.
ChemInform Abstract: Rubiasins A—C, New Anthracene Derivatives from the Roots and Stems of Rubia cordifolia. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ultra fine, ultra soft metallic fibres (1995)

Fine metallic and ceramic fibres with diameters ranging from 5 to 25 microns and lengths up to several meters have been produced by a simple single step fabrication process based on the melt extraction technique. The technology developed permits the production of fine fibres of amorphous or crystalline material from liquids with extremely low viscosity and high surface tension, parameters normally inhibiting fibre production by drawing and similar technologies. We believe that magnetic and mechanical properties of the fibres are linked to complex magnetic and crystallographic structures reflecting the formation of a free surface and "frozen" stress introduced during the radial cooling from the surface to the line of contact. The quenched-in stress strongly affects the crystallographic and magnetic domain structure, and the easy axis of magnetization is usually perpendicular to the fibre length. Examples of practical applications are presented, such as: anti-theft devices, proximity, stress, identification and magnetoresistive sensors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Near-Field Imaging of Free Carriers in ZnO Nanowires with a Scanning Probe Tip Made of Heavily Doped Germanium (2017)

Although scattering-type scanning near-field infrared microscopy can provide access to key parameters of nanomaterials, presently it is performed with unoptimized gold-coated cantilever probes, mainly due to their commercial availability. This work demonstrates that heavily doped germanium, with a midinfrared plasma frequency, is also a good choice for such probes. The peculiarities of IR plasmonic resonances of doped semiconductor nanostructures are highlighted with the aid of multiple-scattering models. This development in coating-free monolithic tips for scanning-probe microscopy could facilitate a lot of nanotechnology research, particularly in plasmonics and photonics.
Inhibition of rotavirus replication by a non-neutralizing, rotavirus VP6–specific IgA mAb (2002)

Rotaviruses are the leading cause of severe diarrheal disease in young children. Intestinal mucosal IgA responses play a critical role in protective immunity against rotavirus reinfection. Rotaviruses consist of three concentric capsid layers surrounding a genome of 11 segments of double-stranded RNA. The outer layer proteins, VP4 and VP7, which are responsible for viral attachment and entry, are targets for protective neutralizing antibodies. However, IgA mAb's directed against the intermediate capsid protein VP6, which do not neutralize the virus, have also been shown to protect mice from rotavirus infection and clear chronic infection in SCID mice. We investigated whether the anti-VP6 IgA (7D9) mAb could inhibit rotavirus replication inside epithelial cells and found that 7D9 acted at an early stage of infection to neutralize rotavirus following antibody lipofection. Using electron cryomicroscopy, we determined the three-dimensional structure of the virus-antibody complex. The attachment of 7D9 IgA to VP6 introduces a conformational change in the VP6 trimer, rendering the particle transcriptionally incompetent and preventing the elongation of initiated transcripts. Based on these observations, we suggest that anti-VP6 IgA antibodies confers protection in vivo by inhibiting viral transcription at the start of the intracellular phase of the viral replication cycle.
CO 2 gas dynamic laser driven by methane-air combustion (1997)

The carbon-dioxide gas dynamic laser driven by methane-air combustion in an unsteady flame propagation combustor was proposed for the purpose of industrial application. The effect of coexisting water with high concentration on the population balance between carbon-dioxide(001) and carbon-dioxide(100) levels of vibration-rotation modes was theoretically analyzed. The analysis showed that the population inversion between the two levels can take place with the methane-air combustion at stoichiometric ratio if the gas flow is accelerated to Mach number 5.0. The population inversion was confirmed by the experimental measurement of the small-signal gain carried out applying the unsteady flame propagation combustion. High emission power of about 2.5 kW with the path length of 0.3 m may be expected from the magnitude of the gain.
A combinatory mucosal vaccine against influenza and botulism (2016)

Abstract Botulinum neurotoxins (BoNTs) are the most poisonous substances known in nature and cause the life-threatening botulism. Currently, there is no FDA licensed botulism vaccine available for public use. Influenza is still an important problem for public health and current influenza vaccines are not optimal for protection against seasonal and potential pandemic influenza. Influenza virus is a negative, segmented RNA virus without DNA intermediate. This makes it safer as a vaccine delivery vector than most DNA viruses that have potential to integrate their genetic elements into host genomes. We hypothesize that a live-attenuated influenza virus expressing botulinum antigens can be developed to a dual use vaccine against both botulism and influenza. Based on influenza virus H1N1 PR8, an engineered influenza viral vector with a 2A cleavage site on NA, was constructed. Using this vector, we generated a recombinant influenza virus, PR8/HC50-rbsd, expressing the receptor binding subdomain of the heavy chain C-terminal receptor binding domain (HC50-rbsd) from BoNT/A. We tested the growth characters of the recombinant PR8/HC50-rbsd virus in chicken eggs and Madin-Darby Canine Kidney epithelial cells (MDCK), and showed that it can be produced to a titer of 5×10E6 plaque forming units/ml in chicken eggs and MDCK cells. Subsequently, mice intranasally vaccinated with the PR8/HC50-rbsd virus conferred protection against challenge with lethal doses of active BoNT/A toxin and wild type H1N1 PR8 influenza virus. Our results demonstrated that it is possible to develop a dual purpose nasal vaccine against both botulism and influenza.
Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development (2006)

Fibroblast growth factor receptor 1 (Fgfr1) plays pleiotropic roles during embryonic development, but the mechanisms by which this receptor signals in vivo have not previously been elucidated. Biochemical studies have implicated Fgf receptor-specific substrates (Frs2, Frs3) as the principal mediators of Fgfr1 signal transduction to the MAPK and PI3K pathways. To determine the developmental requirements for Fgfr1-Frs signaling, we generated mice (Fgfr1(Delta)Frs/DeltaFrs) in which the Frs2/3-binding site on Fgfr1 is deleted. Fgfr1(Delta)Frs/DeltaFrs embryos die during late embryogenesis, and exhibit defects in neural tube closure and in the development of the tail bud and pharyngeal arches. However, the mutant receptor is able to drive Fgfr1 functions during gastrulation and somitogenesis, and drives normal MAPK responses to Fgf. These findings indicate that Fgfr1 uses distinct signal transduction mechanisms in different developmental contexts, and that some essential functions of this receptor are mediated by Frs-independent signaling.
Equilibrium, multistability, and chiral asymmetry in rotated mirror plasmas (2006)

The Hall term in two-fluid magnetohydrodynamics is shown to be necessary to balance the curl of the ion inertial force in a rotating plasma with spatially nonuniform crossed electric and magnetic fields. Two-fluid solutions are obtained that qualitatively explain the multistable rotational response observed in magneto-Bernoulli experiment, imply chiral symmetry breaking, i.e., handedness, and yield new dynamo-like electromotive terms in the effective circuit equation for externally rotated mirror plasma equilibria.
Absence of preferential uptake of [125I]iododihydrorhodamine 123 by four human tumor xenografts. (1989)

The biodistribution of [125I]iododihydrorhodamine 123 has been studied over a 96-h period in four human tumor xenograft models: HT-29 colon adenocarcinoma, PC-3 prostate carcinoma, HT-1080 fibrosarcoma, and PaCa-2 pancreatic carcinoma. Elimination of radioactivity in the tumor-bearing nude mice was rapid during the first 24 h and slow thereafter. The lack of uptake in the thyroid indicated there was little, if any, deiodination of the molecule. Activity was found mainly in the liver and spleen. Accumulation of radioactivity was low in all four tumors examined. At 4 h postinjection, as well as at 24 and 48 h, however, the total radioactive content in each of the four tumors was directly proportional to the weight of the tumor sample. This correlation was independent of tumor type, route of injection (i.v./i.p.) or dose (1.2-6 microCi/mouse). This was not true for any of the normal tissues, suggesting that this accumulation may be governed by certain intrinsic characteristics of the cancers tested.
BEAM PIPE DESORPTION RATE IN RHIC. (2006)

In the past, an increase of beam intensity in RHIC has caused several decades of pressure rises in the warm sections during operation. This has been a major factor limiting the RHIC luminosity. About 430 meters of NEG coated beam pipes have been installed in the warm sections to ameliorate this problem. Beam ion induced desorption is one possible cause of pressure rises. A series beam studies in RHIC has been dedicated to estimate the desorption rate of various beam pipes (regular and NEG coated) at various warm sections. Correctors were used to generate local beam losses and consequently local pressure rises. The experimental results are presented and analyzed in this paper.
Intranasal H5N1 Vaccines, Adjuvanted with Chitosan Derivatives, Protect Ferrets against Highly Pathogenic Influenza Intranasal and Intratracheal Challenge (2014)

We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret model. Six groups of 6 ferrets were intranasally vaccinated twice, 21 days apart, with either placebo, antigen alone, CSN adjuvanted antigen, or TM-CSN adjuvanted antigen. Homologous and intra-subtypic antibody cross-reacting responses were assessed. Ferrets were inoculated intratracheally (all treatments) or intranasally (CSN adjuvanted and placebo treatments only) with clade 1 HPAI A/Vietnam/1194/2004 (H5N1) virus 28 days after the second vaccination and subsequently monitored for morbidity and mortality outcomes. Clinical signs were assessed and nasal as well as throat swabs were taken daily for virology. Samples of lung tissue, nasal turbinates, brain, and olfactory bulb were analysed for the presence of virus and examined for histolopathological findings. In contrast to animals vaccinated with antigen alone, the CSN and TM-CSN adjuvanted vaccines induced high levels of antibodies, protected ferrets from death, reduced viral replication and abrogated disease after intratracheal challenge, and in the case of CSN after intranasal challenge. In particular, the TM-CSN adjuvanted vaccine was highly effective at eliciting protective immunity from intratracheal challenge; serologically, protective titres were demonstrable after one vaccination. The 2-dose schedule with TM-CSN vaccine also induced cross-reactive antibodies to clade 2.1 and 2.2 H5N1 viruses. Furthermore ferrets immunised with TM-CSN had no detectable virus in the respiratory tract or brain, whereas there were signs of virus in the throat and lungs, albeit at significantly reduced levels, in CSN vaccinated animals. This study demonstrated for the first time that CSN and in particular TM-CSN adjuvanted intranasal vaccines have the potential to protect against significant mortality and morbidity arising from infection with HPAI H5N1 virus.
CT-Densitometrie zur Analyse der statischen Druckvolumenkurve der Lunge bei experimentell induziertem Lungenschaden (2005)

Recruitment and derecruitment of lung atelectasis during registration of static in- and expiratory pressure-volume loops occurred constantly, but not in a stepwise manner. CT was shown to be an appropriate method to analyse these recruitment process.
SYSTEMS ENGINEERING OPTIMIZATION OF THE UCF DRIVING SIMULATOR (2000)

This research project had two objectives: (1) involving students in research tasks oriented to transportation in general and driving simulation in particular; and (2) an investigation of the design and possible improvements to the design of the University of Central Florida (UCF) Driving Simulator. Six students were involved in this project, working in the areas of systems and hardware engineering, computer systems design and intercomputer communications, software design, simulated vehicle test engineering, and project support. Specific technical recommendations are offered throughout the report for enhancements to the Driving Simulator. The report is organized in five parts: (1) UCF Driving Simulator; (2) Design Considerations for a Driving Simulator; (3) Related Research; (4) Simulator Vehicle Performance Testing; and (5) Conclusions.
Über Substitutionsreaktionen an Stickstoff‐Schwefel‐Chlor‐Verbindungen (1977)

Abstract HN(SO 2 Cl) 2 reagiert mit Hg[NS(O)F 2 ] 2 zu HN[SO 2 NS(O)F 2 ] 2 ( 1 ) und SO 2 [NS(O)F 2 ] 2 , ( 2 ). Das acide Proton in 1 kann durch (C 6 H 5 ) 4 P + , (C 6 H 5 ) 4 As + , Ag + und Li + ersetzt werden (→ 3–6). Die Reaktion von HN(SO 2 Cl) 2 mit (CH 3 ) 3 SiNSO führt zur cyclischen Verbindung 7, mit CH 3 N[Si(CH 3 ) 3 ] 2 bildet sich SO 2 [NHSi(CH 3 ) 3 ][NCH 3 Si(CH 3 ) 3 ] ( 9 ). Durch die Umsetzung von FSO 2 NSCl 2 mit (CH 3 ) 3 SiNSO wird der Fünfring‐Heterocyclus 8 erhalten.
Type‐c virus‐specific nucleic acid sequences in cultured rat cells (1975)

Single-stranded DNA transcripts of rat type-C viruses prepared in the presence of actinomycin D, hybridized specifically to DNA of several rat cell cultures with no obvious qualitative or quantitative differences. Similar products prepared from a pseudo-type sarcoma virus with contributions from rat and mouse type-C viruses hybridized to both rat and mouse cellular DNA, while mouse viral transcripts did not hybridize to rat cell DNA. Viral RNA was detected in all rat cells by means of the rat viral DNA transcripts, with some differences between untreated low-passage cells and sister cultures treated with bromodeoxyuridine or bromodeoxyuridine and methylcholanthrene. Cells treated with both compounds were previously shown to be transformed and turorigenic, and these were distinguishable by kinetic analysis from the control cells.
Center-of-Pressure Gates for Irrigation (1991)

Center-of-pressure gates, sometimes referred to as pressure gates, were developed and field tested to semi-automate basin and border irrigation systems. The gates use the principle of hydrostatic pressure distribution for operation and are constructed with a pivot shaft located at approximately one-third the water depth above the bottom of the gate. They automatically open with an increment of water level rise in the ditch which is created when companion drop-closed gates close. They can also be equipped with a latch to be activated by a timer or other means. A generalized procedure was developed for designing trapezoidal-shaped pressure gates used in concrete-lined ditches. Pressure gates are being used and field tested in two semi-automated irrigation systems.
Novel Products from the Reaction of Benzyne with Anthracenes (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Products from the Reaction of Benzyne with AnthracenesB. H. KlandermanCite this: J. Am. Chem. Soc. 1965, 87, 20, 4649–4651Publication Date (Print):October 1, 1965Publication History Published online1 May 2002Published inissue 1 October 1965https://pubs.acs.org/doi/10.1021/ja00948a049https://doi.org/10.1021/ja00948a049research-articleACS PublicationsRequest reuse permissionsArticle Views326Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assessment of coregistration of PET H/sub 2//sup 15/O images in the abdomen using digital phantoms (2002)

The aim of this study was to investigate the performance of PET-to-PET coregistration of abdominal H/sub 2//sup 15/O blood flow images from different sessions (before and after anti-cancer treatment) on the same subject. Due to the application-specific nature of image registration methodology, the use of preexisting techniques for new applications requires validation. A quantitative approach was developed based on the Zubal segmented human anatomical phantom in conjunction with blood flow biodistribution data to simulate the activity distribution of a typical PET flow study. Known rotations and translations were applied to the resulting flow software phantom. Poisson noise and spatial resolution of the PET scanner were included in the sinograms created by forward-projection and the reconstructed images were coregistered against a non-transformed reference image using three existing methods: minimisation of standard deviation in the pixel ratio (SPR), multi-resolution maximisation of mutual information (MMI), and K-means variance minimisation (CVM). Assessment based on the transformation matrices shows comparable performance in the range of the transformations assessed (0-15/spl deg/ rotations, 0-15 pixels translations). Assessment based on correlation, residual image and ROI-based results suggest an advantage of MMI for the specific application considered.
Case 35-2001 (2001)

Presentation of CaseAn 81-year-old man was transferred to the hospital because of bradycardia, hypothermia, and increasing confusion.A platelet count of 85,000 per cubic millimeter had been discovered five years before admission, but no cause had been determined. The patient also had a history of coronary artery disease with a reduced ejection fraction as well as chronic obstructive pulmonary disease and chronic cough.Fourteen months before admission, the chronic cough worsened, and a thoracic radiograph revealed a mass in the left lung. A computed tomographic (CT) scan of the chest showed a pleura-based mass, 2.5 cm in diameter, in . . .
Teradiode's high brightness semiconductor lasers (2016)

TeraDiode is manufacturing multi-kW-class ultra-high brightness fiber-coupled direct diode lasers for industrial applications. A fiber-coupled direct diode laser with a power level of 4,680 W from a 100 μm core diameter, <0.08 numerical aperture (NA) output fiber at a single center wavelength was demonstrated. Our TeraBlade industrial platform achieves world-record brightness levels for direct diode lasers. The fiber-coupled output corresponds to a Beam Parameter Product (BPP) of 3.5 mm-mrad and is the lowest BPP multi-kW-class direct diode laser yet reported. This laser is suitable for industrial materials processing applications, including sheet metal cutting and welding. This 4-kW fiber-coupled direct diode laser has comparable brightness to that of industrial fiber lasers and CO<sub>2</sub> lasers, and is over 10x brighter than state-of-the-art direct diode lasers. We have also demonstrated novel high peak power lasers and high brightness Mid-Infrared Lasers.