gebhart/patrepeval huggingface dataset:
Study of the decomposition of SF/sub 6/ in the presence of water, subjected to gamma irradiation or corona discharges (1988)

The influence of water on the degradation of SF/sub 6/ was studied by subjecting mixtures of SF/sub 6/ and H/sub 2/O either to irradiation by /sup 60/Co gamma -rays or to corona discharges (point-plane electrodes; voltage: DC negative or positive polarity). The stable-reaction products formed were analyzed and assayed with various analytical techniques including gas-phase chromatography, gas chromatography-mass spectrometry, specific electrode, colorimetry, atomic absorption, and EDAX (energy-dispersive analysis by X-rays). The influence of the energy input, the water content, the pressure of SF/sub 6/ and, for the corona discharges, the value of the discharge current and the polarity of the applied voltage on the formation of SOF/sub 2/ and SO/sub 2/F/sub 2/ which were the only two stable gaseous compounds detected, were all studied. The results obtained were compared with data from the literature and with the reaction schemes proposed to date, to explain the decomposition of SF/sub 6/ under the effect of similar or different input energies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<title>Prospects For Integrated Optics: 1980-2000</title> (1980)

The accomplishments of the first decade of integrated optics research are reviewed and the present state of the field summarized. Prospects for integrated optical applications in communications, sensing, and optical processing are discussed. A very brief comment on anticipated trends and needs in the field is also given.
Komplexe mit Kohlenstoffsulfiden und ‐seleniden als Liganden, VI. (Dithiocarbonato‐ <i>S,S</i> ′)palladium(II)‐Komplexe durch Templat‐synthese aus Pd(PR <sub>3</sub> ) <sub>n</sub> und COS sowie die Kristallstruktur von (PMe <sub>2</sub> Ph) <sub>2</sub> Pd(S <sub>2</sub> CO) (1982)

Die Komplexe Pd(PMePh2)4, Pd(PMe2Ph)4 und Pd(PiPr3)2 reagieren mit COS zu den (Dithiocarbonato-S,S′)palladium(II)-Verbindungen (PR3)2Pd(S2CO) (1–3). Der Trimethylphosphan-Komplex (PMe3)2Pd(S2CO) (4) ist ausgehend von 1–3 und PMe3 durch Ligandenaustausch erhältlich. Die Verbindung 4 entsteht ebenfalls aus [(PMe3)3PdH]BPh4 und COS über [(PMe3)2Pd(SOCHPMe3)]BPh4 als Zwischenstufe. Die Röntgenstrukturanalyse von 2 zeigt eine nahezu quadratisch-planare Koordination des Metalls mit einem ebenfalls planaren Dithiocarbonat-Liganden. Die Reaktionen von (PPh3)2Pt(η2-COS) mit PMe3 bzw. PMe2Ph führen zu den (Dithiocarbonato-S,S′)platin(II)-Komplexen (PR3)2Pt(S2CO) (5,6). Metal Complexes with Carbon Sulfides and Selenides as Ligands, VI. (Dithiocarbonato-S,S′)palladium(II) Complexes through Template Synthesis from Pd(PR3)n and COS, and the Crystal Structure of (PMe2Ph)2Pd(S2CO) The complexes Pd(PMePh2)4, Pd(PMe2Ph)4 and Pd(PiPr3)2 react with COS to give the (dithiocarbonato-S,S′)palladium(II) compounds (PR3)2Pd(S2CO) (1–3). The trimethylphosphane complex (PMe3)2Pd(S2CO) (4) is obtained by ligand displacement from 1–3 and PMe3. Compound 4 is also formed from [(PMe3)3PdH]BPh4 and COS via [(PMe3)2Pd(SOCHPMe3)]BPh4 as intermediate. The X-ray structure analysis of 2 shows a nearly square-planar coordination of the metal and also a planar dithiocarbonate ligand. The reactions of (PPh3)2Pt(η2-COS) with PMe3 or PMe2Ph lead to the formation of the (dithiocarbonato-S,S′)platinum(II) complexes (PR3)2Pt(S2CO) (5, 6).
Nuclear translocation of <scp>FGFR</scp> 1 and <scp>FGF</scp> 2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion (2014)

Pancreatic cancer is characterised by desmoplasia, driven by activated pancreatic stellate cells (PSCs). Over-expression of FGFs and their receptors is a feature of pancreatic cancer and correlates with poor prognosis, but whether their expression impacts on PSCs is unclear. At the invasive front of human pancreatic cancer, FGF2 and FGFR1 localise to the nucleus in activated PSCs but not cancer cells. In vitro, inhibiting FGFR1 and FGF2 in PSCs, using RNAi or chemical inhibition, resulted in significantly reduced cell proliferation, which was not seen in cancer cells. In physiomimetic organotypic co-cultures, FGFR inhibition prevented PSC as well as cancer cell invasion. FGFR inhibition resulted in cytoplasmic localisation of FGFR1 and FGF2, in contrast to vehicle-treated conditions where PSCs with nuclear FGFR1 and FGF2 led cancer cells to invade the underlying extra-cellular matrix. Strikingly, abrogation of nuclear FGFR1 and FGF2 in PSCs abolished cancer cell invasion. These findings suggest a novel therapeutic approach, where preventing nuclear FGF/FGFR mediated proliferation and invasion in PSCs leads to disruption of the tumour microenvironment, preventing pancreatic cancer cell invasion.
Antiplatelet action of losartan involves TXA2 receptor antagonism but not TXA2 synthase inhibition. (2000)

Various AT1 receptor antagonists including losartan are known to inhibit human platelet activation by antagonising TXA2/PGH2 receptors (TP receptors). Presently, we check a hypothesis that losartan, an imidazole derivative in contrast with valsartan, a non-imidazole compound, may inhibit human platelet activation also through inhibition of TXA2 synthesis. Inhibitory action of losartan (2-n butyl-4-chloro-5-hydroxymethyl-1-beta(2'-(1H-tetrazol-5yl)biphenyl-4-yl)methyl] imidazole), its active metabolite EXP 3174 (2-n-butyl-4-chloro-1-beta (2-(1H-tetrazol-5-yl) biphenyl-4-yl) methyl]imidazole-5-carboxylic acid) and valsartan ((S)-N-valeryl-N-(beta2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]valine), on collagen-induced platelet aggregation and TXA2 generation was compared to effects achieved by each compound on U46619-induced aggregation in aspirinized platelets. Losartan and aspirin inhibited collagen-induced platelet aggregation with approximately the same potency, whereas EXP 3174 and valsartan showed much weaker antiplatelet effects. Interestingly, losartan, EXP 3174 and valsartan displayed similar potencies as inhibitors of U46619-induced aggregation in asprinized platelets as in collagen-induced aggregation in non-aspirinized platelets. None of the above three AT1 antagonists, up to a concentration of 300 microM, did influence collagen-induced TXA2 synthesis in human platelets. In conclusion, antiplatelet effects of AT1 antagonists, irrespective of the presence or absence of non-condensed imidazole in their chemical structure, involve antagonism of TP receptors but not inhibition of TXA2 synthesis in platelets.
A statistical methodology for noise sensor placement and full-chip voltage map generation (2015)

Noise margin violation, also known as voltage emergency induced by continuously reducing noise margin and increasing magnitude of current swings, is becoming a severe threat to the correct execution of applications in processors. Noise sensors can be placed in the non-function area of processors to detect such emergencies by monitoring runtime voltage fluctuations. In this work, we aim to accurately predict the voltage droops using a small set of sensors. We achieve our goal in two steps: We first propose a methodology via group lasso approach to select the optimal set of noise sensors, then build a practical model via ordinary least-squares fitting approach to predict the voltage in the function area of the chip, using the selected sensors in non-function area. Experiment results show that when compared to the full-chip voltage transient simulation, the prediction error of our model is much less than 0.01, and compared to prior work, our approach can achieve better error rates of voltage emergency detection (less than half).
A resistively loaded bowtie antenna for pulse radiation: FDTD analysis and optimization (2002)

The resistively loaded bowtie antenna has been optimized for pulse radiation using the FDTD (finite-difference time-domain) method as the primary design tool. To analyze this structure with available computer resources, several approximations and simplifications had to be introduced into the FDTD model: an approximate model for the feed, staircased edges, a ballooned grid, and closely spaced absorbing boundary conditions. All of these factors can potentially reduce the agreement of the FDTD results with experiment; nevertheless, the FDTD analysis can still serve as a useful design tool for optimizing the antenna.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: Carbamidocyclophanes F and G with anti‐Mycobacterium tuberculosis Activity from the Cultured Freshwater Cyanobacterium Nostoc sp. (2014)

Abstract Carbamidocyclophane F (Ia) shows a potent anti‐Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low‐oxygen‐recovery assay with MIC values of 0.8 and 5.4 μM, respectively.
The <i>pio</i> Operon Is Essential for Phototrophic Fe(II) Oxidation in <i>Rhodopseudomonas palustris</i> TIE-1 (2006)

Phototrophic Fe(II)-oxidizing bacteria couple the oxidation of ferrous iron [Fe(II)] to reductive CO(2) fixation by using light energy, but until recently, little has been understood about the molecular basis for this process. Here we report the discovery, with Rhodopseudomonas palustris TIE-1 as a model organism, of a three-gene operon, designated the pio operon (for phototrophic iron oxidation), that is necessary for phototrophic Fe(II) oxidation. The first gene in the operon, pioA, encodes a c-type cytochrome that is upregulated under Fe(II)-grown conditions. PioA contains a signal sequence and shares homology with MtrA, a decaheme c-type cytochrome from Shewanella oneidensis MR-1. The second gene, pioB, encodes a putative outer membrane beta-barrel protein. PioB is a homologue of MtrB from S. oneidensis MR-1. The third gene, pioC, encodes a putative high potential iron sulfur protein (HiPIP) with a twin-arginine translocation (Tat) signal sequence and is similar to the putative Fe(II) oxidoreductase (Iro) from Acidithiobacillus ferrooxidans. Like PioA, PioB and PioC appear to be secreted proteins. Deletion of the pio operon results in loss of Fe(II) oxidation activity and growth on Fe(II). Complementation studies confirm that the phenotype of this mutant is due to loss of the pio genes. Deletion of pioA alone results in loss of almost all Fe(II) oxidation activity; however, deletion of either pioB or pioC alone results in only partial loss of Fe(II) oxidation activity. Together, these results suggest that proteins encoded by the pio operon are essential and specific for phototrophic Fe(II) oxidation in R. palustris TIE-1.
NMDA-receptor-dependent, muscimol-sensitive role of the entorhinal cortex in post-training memory processing (1992)

The bilateral infusion into the entorhinal cortex of the NMDA receptor antagonist, AP5 (5.0µg) or of the GABA(A) agonist, muscimol (0.03µg) 90min after training but not 30min before training, 0min after training or 10min before testing, hindered retention test performance 24h after inhibitory avoidance in rats. Glutamate (5.0µg) or picrotoxin (0.08µg) infused 90min after training had no effect. In animals trained with a low level footshock a second training session, 120min after the first, was needed in order to obtain a good retention test performance. This was taken to reflect summation of the consecutive memory traces left by the two training sessions. In these animals, the infusion of AP5 or muscimol into the entorhinal cortex between the two training sessions impeded their summation. The present results suggest that the entorhinal cortex plays a late role in memory processing, that this role does not need a hyperactivation of the entorhinal cortex, and that it is important for the interaction between consecutive memory traces.
Clonal and systemic analysis of long-term hematopoiesis in the mouse. (1990)

We have analyzed the temporal in vivo fate of 142 individual stem cell clones in 63 reconstituted mice. Long-term sequential analyses of the four major peripheral blood lineages, obtained from animals engrafted with genetically marked stem cells, indicate that developmental behavior is primarily a function of time. As such, the first 4-6 months post-engraftment is characterized by frequent fluctuations in stem cell proliferation and differentiation behavior. Gradually, a stable hematopoietic system emerges, dominated by a small number of totipotent clones. We demonstrate that single stem cell clones are sufficient to maintain hematopoiesis over the lifetime of an animal and suggest that mono- or oligoclonality may be a hallmark of long-term reconstituted systems. A model is proposed, wherein lineage-restricted differentiation and dramatic clonal flux are consequences of mechanisms acting on an expanding pool of totipotent cells and are not indicative of intrinsically distinct stem cell classes.
Immune Dysfunctions of Cultured T Lymphocytes Are Due to a Preferential Expansion of CD4+CD25+ Suppressor Cells. (2005)

Abstract We investigated the causes of the altered functionality of T-cells cultured under conditions designed for cell and gene therapy and the strategies to prevent their defects. We first showed that human T-cells cultured for 6-days with anti-CD3 ± anti-CD28 antibodies and interleukin-2 presented a 50% decrease of their proliferative responses to allogeneic or recall antigens. Similarly, day-6 cultured murine T-cells completely lost their capacity to reject allogeneic skin grafts and to provoke graft versus host disease (GVHD) when infused into irradiated semi-allogeneic mice. Interestingly, injection of higher amount of cultured T-cells restored GVHD induction. Moreover, depletion of CD25+ cells prior to T-cell cultures can prevent these deficiencies both in mice and human. Therefore, we demonstrated that culture conditions used for T-cell therapy preferentially activated and expanded regulatory T-cells (Treg) and thus, we showed that dividing cells sorted from T-cell cultures strongly suppressed the proliferation of autologous T-cells in response to allogeneic stimulation. An increased detection of Foxp3 at mRNA and protein levels in the cultures confirmed the Treg expansion. Overall, we demonstrate that T-cell cultures promote Treg expansion over effector T-cells, leading to deleterious immune functions, and that this imbalance can be prevented by an initial depletion of CD25+ cells.
Impaired T cell proliferation, increased soluble death-inducing receptors and activation-induced T cell death in patients undergoing haemodialysis (2001)

Haemodialysis is a widespread option for end-stage renal disease (ESRD). Long-term success of dialysis is, however, limited by a high rate of serious bacterial and viral infections. We compared T cell functions in ESRD patients undergoing haemodialysis (n = 20), or were not dialysed and received conventional medical treatment (n = 20). Healthy volunteers (n = 15) served as controls. The T cell phenotype was examined by immunofluorescence using fluorochrome-labelled monoclonal antibodies and FACS analysis. The concentration of soluble CD95/Fas and of tumour necrosis factor-alpha receptor type 1 (sTNFR1) in the sera was quantified by ELISA. Activation-induced programmed T cell death was triggered by anti-CD3/CD28 antibodies and measured by 7-AAD staining. All immunological tests were performed at least 1 month after dialysis initiation. T cell proliferation in response to phytohaemagglutinin or anti-CD3 monoclonal antibodies was moderately diminished in non-dialysed patients and markedly reduced in haemodialysis patients compared to healthy controls (P < 0.01 and P < 0.001, respectively). In a mixed lymphocyte culture the proliferative response of T cells from dialysed patients was significantly diminished (P < 0.001). T cells of both non-dialysed and dialysed patients have augmented CD95/Fas and CD45RO expression, increased sCD95/Fas and sTNFR1 release and spontaneously undergo apoptosis. Culture of T cells from haemodialysis patients with anti-CD3/CD28 antibodies increased the proportion of CD4(+) T cells committing activation-induced cell death by a mean 7.5-fold compared to T-helper cells from non-dialysed patients (P < 0.001). Renal failure and initiation of haemodialysis results in a reduced proliferative T cell response, an aberrant state of T cell activation and heightened susceptibility of CD4(+) T cells to activation-induced cell death.
A Molecular Einstein Ring: Imaging a Starburst Disk Surrounding a Quasi-Stellar Object (2003)

Images of the molecular CO 2-1 line emission and the radio continuum emission from the redshift 4.12 gravitationally lensed quasi-stellar object (QSO) PSS J2322+1944 reveal an Einstein ring with a diameter of 1.5". These observations are modeled as a star-forming disk surrounding the QSO nucleus with a radius of 2 kiloparsecs. The implied massive star formation rate is 900 solar masses per year. At this rate, a substantial fraction of the stars in a large elliptical galaxy could form on a dynamical time scale of 108 years. The observation of active star formation in the host galaxy of a high-redshift QSO supports the hypothesis of coeval formation of supermassive black holes and stars in spheroidal galaxies.
Bone dimensional variations at implants placed in fresh extraction sockets: a multilevel multivariate analysis (2009)

Clinicians must consider the thickness of the buccal bony wall in the extraction site and the vertical as well as the horizontal positioning of the implant in the socket, because these factors will influence hard tissue changes during healing.
Auxin Metabolism in Representative Land Plants (1995)

The plant hormone auxin (indole-3-acetic acid, IAA) appears to control many plant developmental processes, and studies performed in seed plants suggest that IAA conjugation is the critical mechanism to regulate free IAA concentration. The purpose of this investigation is to characterize the biochemical ability of one charophyte and 23 land plants ranging from liverworts to angiosperms to produce IAA conjugates, and to study the complexity of their conjugation patterns. Actively growing tissue was incubated with 14C-IAA, after which labeled IAA conjugates were separated using thin-layer chromatography. The conjugates were analyzed using radioimaging techniques and their tentative identity assigned by co-chromatography and/or by differential hydrolysis. The charophyte and the liverworts appear unable to conjugate IAA. The mosses and the hornwort are able to conjugate IAA into a few amide and ester conjugates. The tracheophytes examined synthesize several conjugates unique to the vascular plants, indole-3-acetyl-aspartic acid (-glutamic acid) and/or indole-3-acetyl-β-1-O-glucose, as well as a variety of other amide and ester conjugates. These three conjugation patterns are correlated to the type of conducting tissue characteristic of the plants analyzed. These biochemical differences may be indicative of significative differences in the hormonal regulation in these plant groups, thus suggesting that changes in IAA regulation accompanied the major evolutionary events in land plants.
Depression and Risk of Sudden Cardiac Death After Acute Myocardial Infarction: Testing for the Confounding Effects of Fatigue (1999)

Symptoms of depression and fatigue overlap in patients with MI. The trend for the cognitive-affective symptoms of depression to be associated with SCD risk, even after controlling for dyspnea/fatigue, suggests that the association between depression and mortality after AMI cannot be entirely explained as a confound of cardiac-related fatigue. The independent contribution of social participation suggests a role of both depressive symptomatology and social factors in influencing mortality risk after MI.
From the lab bench to the plant: how to commercialize a metallocene catalyst? (2001)

In order to apply metallocene catalysts for the polymerization of ethylene in the commercial “slurry loop process” it is necessary to heterogenize the homogeneous catalysts and to produce resins with attractive properties. A solution to these problems is the self-immobilization of ω-alkenyl functionalized catalysts that can produce polyethylenes with evenly distributed ethyl branches in the polymer chain without a comonomer. The new resin is produced at Chevron Phillips Company, USA, and has the trade name mPact.
DREAM RECALL AND EYE MOVEMENTS DURING SLEEP IN SCHIZOPHRENICS AND NORMALS (1955)

The Journal of Nervous and Mental Disease: September 1955 - Volume 122 - Issue 3 - p 263-269
Inverse substrates for trypsin and trypsin-like enzymes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInverse substrates for trypsin and trypsin-like enzymesKazutaka Tanizawa, Yuichi Kanaoka, and William B. LawsonCite this: Acc. Chem. Res. 1987, 20, 9, 337–343Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://doi.org/10.1021/ar00141a004Request reuse permissionsArticle Views124Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (844 KB) Get e-Alertsclose Get e-Alerts
Aspects of Prepreg Layer Friction on Defect Formation on Thick-Walled Composite Manufacturing (2017)

As composite manufacturing processes evolve and composite structures become ever more complex the role of geometry and built-in geometric features increase the role of ply movement during mold closure and compaction. With a greater amount of constraints and ply movement, the friction that develops between the prepreg plies and the tooling surfaces and/or between one ply to another become a significant force which is a factor in formation of defects such as ply wrinkles. As such a greater understanding of ply friction and its implementation into process modeling is justified. In this work Hexcel IM7/8552 8HS, is characterized for ply friction using a custom characterization rig. The rig compresses a layer of prepreg onto a tooling surface with a prescribed pressure and heats the prepreg layer in accordance to an autoclave heating cycle while pulling the tooling surface out in a testing frame capable of measuring the required force to do so. Current simulation tools for modeling the autoclave process in order to predict outcomes such as a structures spring-in due to manufacturing utilize only simple models for this frictional behavior. This work uses an approach with currently available tools to implement experimentally determined ply friction data for modeling the manufacturing process using user subroutines. Results of simulation predicts that compression along the fiber direction during the compaction stage of the autoclave cycle is concentrated in the radius region which is experimentally shown to cause ply wrinkling. In conclusion this work will present various aspects of ply friction characterization, coupon level experimentation with curved beam samples, and process modeling.