gebhart/patrepeval huggingface dataset:
Scale-model rocket experiments (SRE) (1998)

The Scale model Rocket Experiments (SRE) were conducted in August and September 1997 as a part of the Ballistic Missile Defense Organization (BMDO) Advanced Sensor Technology Program (ASTP) and Discriminating Interceptor Technology Program (DITP). Rome Laboratory (RL) efforts under this effort for ASTP involves the following technology areas: sensor fusion algorithms, high performance processors, and sensor modeling and simulation. In support of the development, test and integration of these areas, Rome Laboratory performed the scale model rocket experiments. This paper details the experiments and results of the scaled rocket experiment as a cost effective, risk reduction experiment to test fusion processor algorithms in a real time environment. The goals of the experiment were to launch, track, fuse, and collect multispectral data from Visible, IR, RADAR and LADAR sensors. The data was collected in real time and was interfaced to the RL-HPC (PARAGON) for real time processing. In June 1997 RL performed the first tests of the series on static targets. The static firings tested data transfers and safety protocols. The RL (Hanscom) IR cameras were calibrated and the proper gain settings were acquired. The next phase of the SRE testing, August 12/13 1997, involved the launching, tracking and acquiring digital IR data into the HPC. In September, RL implemented the next phase of the experiments by incorporating a LADAR and an additional IR sensor from Phillips Laboratory into the system. This paper discusses the success and future work of the SRE.
Radio-frequency Identification systems providing Privacy protection in Ubiquitous Computing (2004)

To investigate the role of endothelium-derived nitric oxide (EDNO) and adenosine in functional myocardial hyperemia, we examined the effect of NG-nitro-L-arginine (L-NNA) and 8-p-sulfophenyltheophylline (8-SPT) on coronary vasodilation in response to increased myocardial oxygen consumption in pentobarbital sodium-anesthetized dogs. L-NNA significantly attenuated the increase in coronary conductance from 28 +/- 6 to 16 +/- 2% with atrial pacing, from 69 +/- 5 to 36 +/- 6% with isoproterenol, and from 25 +/- 6 to 9 +/- 4% with constriction of the aorta. 8-SPT given alone attenuated the increase in coronary conductance to the same extent as L-NNA. The combined administration of L-NNA and 8-SPT did not further change coronary conductance. These findings suggest that EDNO and adenosine play an important role in functional hyperemia. EDNO-induced functional hyperemia appears to be dependent on adenosine receptor activation.
Reactions of Boron Amidinates with CO<sub>2</sub> and CO and Other Small Molecules (2010)

Reaction of Piers' borane, HB(C(6)F(5))(2), with either tert-butyl or isopropyl carbodiimide cleanly affords the boron amidinates HC(RN)(2)B(C(6)F(5))(2) [R = iPr (1), tBu (2)]. These species undergo a variety of insertion reactions. For example, treatment of 1 with CO(2) or excess carbodiimide gives HC(iPrN)(2)(CO(2))B(C(6)F(5))(2) (3) or HC(iPrN)(2)C(iPrN)(2)B(C(6)F(5))(2) (4), respectively. Similarly, exposure of 1 or 2 to 1 atm CO gives HC(RN)(2)(CO)B(C(6)F(5))(2) [R = iPr (5), tBu (6)], while reaction of 1 with CNtBu gives HC(RN)(2)(CNtBu)B(C(6)F(5))(2) [R = iPr (7), tBu (8)]. Compounds 1 and 2 also react with benzaldehyde, resulting in the formation of HC(RN)(2)(PhHCO)B(C(6)F(5))(2) [R = iPr (9), tBu (10)]. Compound 1 also reacts with MeCN to give HC(iPrN)(2)(MeCN)B(C(6)F(5))(2) (11) and effects heterolytic C-H cleavage to afford HC(iPrN)(iPrNH)(PhCC)B(C(6)F(5))(2) (12). In contrast, the species PhC(iPrN)(2)B(C(6)F(5))(2) (14) derived from PhC(iPrN)(2)BCl(2) (13) failed to react with any of the above substrates. These data, in addition to the isolation of HC(iPrN)(2)(C(6)F(4))BF(C(6)F(5)) (15), the product of thermolysis of 1, provide further support for the notion that the transient "open-chain" form of these amidinates is present in solution.
Continued inhibition of radiographic progression in patients with psoriatic arthritis following 2 years of treatment with etanercept. (2006)

These data demonstrate a sustained benefit of etanercept treatment, including inhibition of radiographic progression, in patients with PsA.
Deregulation of c- <i>myc</i> Gene Expression in Human Colon Carcinoma Is Not Accompanied by Amplification or Rearrangement of the Gene (1985)

The structure and expression of the c-myc oncogene were examined in 29 primary human colon adenocarcinomas. Dot blot hybridization of total RNA showed that 21 tumors (72%) had considerably elevated expression of c-myc (5- to 40-fold) relative to normal colonic mucosa. These data were corroborated by Northern blots of polyadenylated RNA, which showed a 2.3-kilobase transcript. Southern analysis of the c-myc locus in these tumors indicated the absence of amplification or DNA rearrangement in a 35-kilobase region encompassing the gene. In a parallel study, elevated expression of c-myc without amplification or DNA rearrangement was also observed in three of six colon carcinoma cell lines examined; in addition, unlike a normal colon cell line control, these three cell lines exhibited constitutive, high-level expression of the gene during their growth in cultures. These results indicate that elevated expression of the c-myc oncogene occurs frequently in primary human colon carcinomas and that the mechanism involved in the regulation of c-myc expression is altered in tumor-derived cell lines.
Phosphorus-Containing Dendrimers as Multidentate Ligands:  Palladium, Platinum, and Rhodium Complexes (1997)

New dendrimers 3-[G‘1]−3-[G‘4] possessing from 6 to 48 N(CH2PPh2)2 terminal groups are described. The corresponding Pd, Pt, and Rh complexes [N(CH2PPh2)2MRR‘]y (y from 6 to 24; generations 1−3) [M = Pd: R = R‘ = Cl, Br; R = Cl, R‘ = Me; R = Br, R‘ = Me; R = Cl, R‘ = COMe; R = Cl, R‘ = norbornyl-COMe. M = Pt: R = R‘ = Br, Cl, Me; R = Br, R‘ = Me. M = Rh: R, R‘ = acac] are prepared by reacting 3-[G‘1]−3-[G‘3] with the appropriate transition metal complexes.
Effects of bacitracin methylene disalicylate and diet change on gastrointestinal integrity and endotoxin permeability in the duodenum of broiler chicken (2017)

Birds were raised on a starter diet without growth promoting antibiotics for 31 days then switched to a grower diet. Four of the pens including 50 g/ton of BMD while 4 pens remained antibiotic free. Eight birds per treatment were sampled prior to the feed change and at 3 and 7 days following the feed change. Gastrointestinal integrity and endotoxin permeability in the duodenum were determined using a modified Ussing Chamber and an adjacent section fixed in 10% formalin for morphometric analysis. Data were analyzed using Proc Glimmix of SAS with the model fitting BMD treatment, time, and the interaction of BMD treatment and time as fixed effects. Intestinal integrity increased at d 3 and 7 compared to prior to the feed change and addition of BMD (P > 0.001) and villus height was decreased with BMD supplementation (P = 0.049). All other tested effects similar (P > 0.1). In conclusion, the practice of changing feed had a greater effect on intestinal health than addition of BMD. However, the factors driving these differences 42 are unclear.
The 15-lipoxygenase product, 8R,15S-diHETE, stereospecifically sensitizes C-fiber mechanoheat nociceptors in hairy skin of rat (1990)

1. This study examined the effects of the 15-lipoxygenase product of arachidonic acid metabolism, (8R,15S)-dihydroxyicosa-(5E-9,11,13Z)tetraenoic acid (8R,15S-diHETE), on mechanical thresholds and thermal responses of saphenous nerve cutaneous C-fiber nociceptors that innervate the hairy skin of the rat hindpaw. Single C-fiber mechanoheat nociceptors (C-MH) that had von Frey hair (VFH) thresholds greater than 5 g and were activated by a noxious heat stimulus were chosen for study. We also studied the effects of prostaglandin E2 (PGE2), a cyclooxygenase product of arachidonic acid metabolism, on these nociceptors. 2. The 63 C-MHs studied had a conduction velocity of 0.82 +/- 0.03 m/s (mean +/- SE) and a mechanical threshold of 13.4 +/- 2.4 g. In a subgroup of these (n = 24), the thermal threshold was measured as (44 +/- 1 degree C) (mean +/- SE). 3. 8R,15S-diHETE produced a significant decrease in mechanical threshold of C-MHs (n = 33). The 8R,15S-diHETE-induced sensitization of C-MHs to mechanical stimuli was completely antagonized by coadministration with a stereoisomer, 8S,15S-diHETE (n = 10). 4. The mechanical threshold of C-MHs (n = 10), previously injected with the combination of 8R,15S-diHETE and 8S,15S-diHETE, was significantly reduced by a subsequent injection of PGE2. In a separate group of C-MHs (n = 7), PGE2 was co-injected with 8S,15S-diHETE, which failed to antagonize the sensitizing effect of PGE2 on mechanical threshold. 5. 8R,15S-diHETE also sensitized C-MHs (n = 9) to a thermal stimulus consisting of 37 degrees C for 5 min.(ABSTRACT TRUNCATED AT 250 WORDS)
Synthesis of alloy carbides by the activated reactive evaporation process (1975)

Several of the carbides of the group IV, V, VI elements exhibit complete solid solubility in each other. Specific compositions of the alloy carbides exhibit melting point maxima. This investigation was concerned with the deposition of alloy carbides using the activated reactive evaporation process. [R. F. Bunshah and A. C. Raghuram, J. Vac. Sci. Technol. 9, 1385 (1972)]. A Ti−6Al−4V alloy rod was evaporated from an eb source in the presence of a partial pressure of C2H2 with all the vapor species being activated or partially ionized using the A.R.E. process. The deposits were characterized by x−ray diffraction and electron microprobe analysis. It was established that an alloy carbide deposit corresponding to a TiC−VC solid solution, with possibly Al present in the microstructure, was produced.
Widely Applicable Coinage Metal Window Electrodes on Flexible Polyester Substrates Applied to Organic Photovoltaics (2012)

The fabrication, exceptional properties, and application of 8 nm thick Cu, Ag, Au, and Cu/Ag bilayer electrodes on flexible polyethylene terephthalate (PET) and polyethylene naphthalate (PEN) substrates is reported. These electrodes are fabricated using a solvent free process in which the plastic surface is chemically modified with a molecular monolayer of thiol and amine terminated alkylsilanes prior to metal deposition. The resulting electrodes have a sheet resistance of ≤14 Ω sq⁻¹, are exceptionally robust and can be rapidly thermally annealed at 200 °C to reduce their sheet resistance to ≤9 Ω sq⁻¹. Notably, annealing Au electrodes briefly at 200 °C causes the surface to revert almost entirely to the {111} face, rendering it ideal as a model electrode for fundamental science and practical application alike. The power conversion efficiency of 1 cm² organic photovoltaics (OPVs) employing 8 nm Ag and Au films as the hole-extracting window electrode exhibit performance comparable to those on indium-tin oxide, with the advantage that they are resistant to repeated bending through a small radius of curvature and are chemically well-defined. OPVs employing Cu and bilayer Cu:Ag electrodes exhibit inferior performance due to a lower open-circuit voltage and fill factor. Measurements of the interfacial energetics made using the Kelvin probe technique provide insight into the physical reason for this difference. The results show how coinage metal electrodes offer a viable alternative to ITO on flexible substrates for OPVs and highlight the challenges associated with the use of Cu as an electrode material in this context.
The aminolysis of N-hydroxysuccinimide esters. A structure-reactivity study (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe aminolysis of N-hydroxysuccinimide esters. A structure-reactivity studyGary W. Cline and Samir B. HannaCite this: J. Am. Chem. Soc. 1987, 109, 10, 3087–3091Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/ja00244a035https://doi.org/10.1021/ja00244a035research-articleACS PublicationsRequest reuse permissionsArticle Views5802Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dietary Fat Intake Determines the Effect of a Common Polymorphism in the Hepatic Lipase Gene Promoter on High-Density Lipoprotein Metabolism (2002)

Dietary fat intake modifies the effect of the -514(C/T) polymorphism on HDL-C concentrations and subclasses. Specifically, in the Framingham Study, TT subjects may have an impaired adaptation to higher animal fat diets that could result in higher cardiovascular risk.
The Crystal Structure of SDR-Type Pyridoxal 4-Dehydrogenase of<i>Mesorhizobium loti</i> (2011)

Pyridoxal 4-dehydrogenase catalyzes the irreversible oxidation of pyridoxal to 4-pyridoxolactone and is involved in degradation pathway I of pyridoxine, a vitamin B(6) compound. Its crystal structure was elucidated for the first time. Molecular replacement with (S)-1-phenylthanol dehydrogenase (PDB code 2EW8) was adopted to determine the tertiary structure of the NAD(+)-bound enzyme.
The effect of cadmium chloride treatment on close spaced sublimated cadmium telluride thin film solar cells (2012)

The aim of this investigation is to apply advanced microstructural characterization techniques to study the effect of the cadmium chloride treatment on the physical properties of cadmium telluride solar cells deposited via close-spaced sublimation (CSS) and relate these to cell performance. A range of techniques have been used to observe the microstructural changes as well as the chemical changes before and after cadmium chloride treatment. Electrical measurements that link the device performance with the microstructural properties of the cells have also been undertaken. Transmission Electron Microscopy (TEM) has revealed high densities of stacking faults in the as-grown CdTe samples. Further, it has been observed that these stacking faults are removed during the cadmium chloride treatment. These observations show that the presence of chlorine plays an important role in the removal of these defects and the subsequent production of high efficiency thin film CdTe solar cells. Elemental analysis in the TEM indicates chlorine rich regions appearing at the CdTe/CdS interface as well as at grain boundaries after the treatment.
CATIE and CUtLASS: can we handle the truth? (2008)

Two large, non-commercial clinical trials comparing first- and second-generation antipsychotic drugs for people with chronic schizophrenia in the US and UK have shown unexpected results. In general, the newer drugs were no more effective or better tolerated than the older drugs. Clozapine outperformed other second-generation drugs. The implications are considered.
Thermodynamic Contributions for the Incorporation of GTA Triplets within Canonical TAT/TAT and C<sup>+</sup>GC/C<sup>+</sup>GC Base-Triplet Stacks of DNA Triplexes (2002)

Nucleic acid triple helices may be used in the control of gene expression. One limitation of using triplex-forming oligonucleotides as therapeutic agents is that their target sequences are limited to homopurine tracts. To increase the repertoire of sequences that can be targeted, it has been postulated that a guanine can target a thymidine forming a stable GTA mismatch triplet. In this work, we have used a combination of optical and calorimetric techniques to determine thermodynamic unfolding profiles of two triplexes containing a single GTA triplet, d(A3TA3C5T3AT3C5T3GT3) (ATA) and d(AGTGAC5TCACTC5TCGCT) (GTG), and their control triplexes, d(A7C5T7C5T7) (TAT7) and d(AGAGAC5TCTCTC5TCTCT) (AG5T). In general, the presence of a GTA mismatch in DNA triplexes is destabilizing; however, this destabilization is greater when placed in a C+GC/C+GC base-triplet stack than between a TAT/TAT stack. These destabilizations are accompanied by a reduced unfolding enthalpy of ∼10 kcal/mol, suggesting a decrease in the base stacking contributions surrounding the mismatch. Relative to their corresponding control triplexes, the folding of ATA is accompanied by a lower counterion uptake and a similar proton uptake, while GTG folding is accompanied by an increase in the counterion and proton uptakes. These effects are consistent with the observed decrease in stacking interactions. The overall results indicate that the main difficulty of targeting pyrimidine interruptions is that the decrease in stacking contributions, due to the incorporation of a GTA mismatch, affects the stability of the neighboring base triplets. This suggests that nucleotide analogues that increase the strength of these base-triplet stacks will result in a more effective targeting of pyrimidine interruptions.
Grande-Bretagne : Le gouvernement contre les villes (1988)

Großbritannien, Die Regierung gegen die Städte In zehn Jahren permanenter Reformen ist die Struktur der Beziehungen zwischen Zentralregierung und Lokalverwaltung grundlegend umgewälzt worden. Der Umfang der Reformen zur Finanzkontrolle und die Schaffung zentraler, mit bestimmten Stadterneuerungsprojekten beauftragter Ämter haben eine gravierende Zentralisierung und entsprechende Widersprüche zur Folge.
Double-Strand Break Repair in Plants Is Developmentally Regulated  (2006)

In this study, we analyzed double-strand break (DSB) repair in Arabidopsis (Arabidopsis thaliana) at various developmental stages. To analyze DSB repair, we used a homologous recombination (HR) and point mutation reversion assays based on nonfunctional beta-glucuronidase reporter genes. Activation of the reporter gene through HR or point mutation reversion resulted in the appearance of blue sectors after histochemical staining. Scoring of these sectors at 3-d intervals from 2 to 31 d post germination (dpg) revealed that, although there was a 100-fold increase in the number of genomes per plant, the recombination frequency only increased 30-fold. This translates to a recombination rate at 31 dpg (2.77 x 10(-8)) being only 30% of the recombination rate at 2 dpg (9.14 x 10(-8)). Conversely, the mutation frequency increased nearly 180-fold, resulting in a 1.8-fold increase in mutation rate from 2 to 31 dpg. Additional analysis of DSBs over the early developmental stages revealed a substantial increase in the number of strand breaks per unit of DNA. Furthermore, RNA analysis of Ku70 and Rad51, two key enzymes in two different DSB repair pathways, and further protein analysis of Ku70 revealed an increase in Ku70 levels and a decrease of Rad51 levels in the developing plants. These data suggest that DSB repair mechanisms are developmentally regulated in Arabidopsis, whereby the proportion of breaks repaired via HR substantially decreases as the plants mature.
Elastic Stiffness Coefficients of Iron from 77° to 673°K (1965)

The elastic stiffness coefficients of single-crystal iron have been measured at room (300°K) and liquid-nitrogen (77°K) temperatures using the ultrasonic pulse-echo technique. The three coefficients were determined from a total of seven independent modes. The values at 300°K are C11=2.28±0.02, C12=1.32 ±0.04, and C44=1.165±0.01, in units of 1012 dyn/cm2; the corresponding values at 77°K are 2.36±0.02, 1.34±0.04, and 1.19±0.01. The coefficients C11, (C11+C12+2C44)/2, and (C11+2C12+4C44)/3 of iron have been measured from 77° to about 673°K. C11 and (C11+2C12+4C44)/3, as well as the polycrystalline stiffness λ+2μ, depart from a linear dependence on temperature above about 300°C. It was not possible to say whether the same effect occurred in (C11+C12+2C44)/2 because of significant scatter in the data. The Debye temperature Θ0 was found from the stiffnesses extrapolated to 0°K, to be 471.5°K.
Drift reduction in an optical heterodyne fiber gyro (1990)

An optical heterodyne fiber gyro, which we recently proposed, is improved to reduce the zero-point drift. A reference interferometer is introduced in the improved configuration beside the sensing interferometer to obtain the Sagnac phase shift, which monitors the drift caused in the optical system. Experimental results demonstrate successful reduction of the drift.
Surface Modification of Nonviral Nanocarriers for Enhanced Gene Delivery (2013)

Biomedical nanotechnology has given a new lease of life to gene therapy with the ever-developing and ever-diversifying nonviral gene delivery nanocarriers. These are designed to pass a series of barriers in order to bring their nucleic acid cargo to the right subcellular location of particular cells. For a given application, each barrier has its dedicated strategy, which translates into a physicochemical, biological and temporal identity of the nanocarrier surface. Different strategies have thus been explored to implement adequate surface identities on nanocarriers over time for systemic delivery. In that context, this review will mainly focus on organic nanocarriers, for which these strategies will be described and discussed.
Integrating Verification and Repair into the Control Plane (2017)

Network verification has made great progress recently, yet existing solutions are limited in their ability to handle specific protocols or implementation quirks or to diagnose and repair the cause of policy violations. In this positioning paper, we examine whether we can achieve the best of both worlds: full coverage of control plane protocols and decision processes combined with the ability to diagnose and repair the cause of violations. To this end, we leverage the happens-before relationships that exist between control plane I/Os (e.g., route advertisements and forwarding updates). These relationships allow us to identify when it is safe to employ a data plane verifier and track the root-cause of problematic forwarding updates. We show how we can capture errors before they are installed, automatically trace down the source of the error and roll-back the updates whenever possible.
Detektion von Koronararterien Das Beste aus zwei Welten (2011)

Kurzfassung. Die vorliegende Arbeit stellt einen neuen Algorithmus zur hochgenauen und mvollstDetektion von Koronarar- terien vor. Hierfwerden Ansder zwei hAlgorith- men des Wettbewerbs A Grand Challenge in the Clinic II (MICCAI 2008) verknerweitert und optimiert. Die Ergebnisse zeigen, dass der Algorithmus bei leicht verbesserter Genauigkeit einen wesentlich h¨ ren Overlap erzielt als der Gewinneralgorithmus der automatischen und semi-automatischen Kategorie.