gebhart/patrepeval huggingface dataset:
Narrow-band oscillations in probabilistic cellular automata (2008)

Dynamical properties of neural populations are studied using probabilistic cellular automata. Previous work demonstrated the emergence of critical behavior as the function of system noise and density of long-range axonal connections. Finite-size scaling theory identified critical properties, which were consistent with properties of a weak Ising universality class. The present work extends the studies to neural populations with excitatory and inhibitory interactions. It is shown that the populations can exhibit narrow-band oscillations when confined to a range of inhibition levels, with clear boundaries marking the parameter region of prominent oscillations. Phase diagrams have been constructed to characterize unimodal, bimodal, and quadromodal oscillatory states. The significance of these findings is discussed in the context of large-scale narrow-band oscillations in neural tissues, as observed in electroencephalographic and magnetoencephalographic measurements.
Effects of bonding pressure on quality of SLID interconnects (2012)

The investigation of the bonding pressure change on the different quality aspects of the solid-liquid interdiffusion (SLID) interconnects is presented. The stacks were produced by a flux-assisted bonding of two Si dies with an area array of square Cu/SnAg bumps on the bottom die and Cu bumps on the top die at approx. 250 °C. The bonding pressure was varied between 0 MPa, 0.35 MPa, 0.69 MPa, 1.04 MPa, 1.38 MPa, 1.73 MPa, 2.08 MPa, 2.42 MPa. Cross-sections of the stacks were analyzed by optical microscopy and scanning electron microscopy (SEM). Tilt, standoff height (SOH) variation, void fraction, interlayer thickness and Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn thickness were measured. It will be shown that increase of the bonding pressure can reduce the void fraction from 35.1 % (0 MPa) to 10.7 % (2.42 MPa) and decrease the interlayer thickness at the same time. Decrease of the interlayer thickness is accompanied by solder squeeze and increase of Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn thickness. Shear tests revealed an average shear strength of (81.3 ± 21.5) MPa for the produced samples. The analysis of the fracture surfaces with SEM revealed that the weakest interface is located between Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</inf> Sn <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</inf> and Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn intermetallic compounds (IMCs) close to the initial Cu bump.
Biarylmethoxy Nicotinamides As Novel and Specific Inhibitors of <i>Mycobacterium tuberculosis</i> (2014)

A whole cell based screening effort on a focused library from corporate collection resulted in the identification of biarylmethoxy nicotinamides as novel inhibitors of M. tuberculosis (Mtu) H37Rv. The series exhibited tangible structure-activity relationships, and during hit to lead exploration, a cellular potency of 100 nM was achieved, which is an improvement of >200-fold from the starting point. The series is very specific to Mtu and noncytotoxic up to 250 μM as measured in the mammalian cell line THP-1 based cytotoxicity assay. This compound class retains its potency on several drug sensitive and single drug resistant clinical isolates, which indicate that the compounds could be acting through a novel mode of action.
Bone marrow mesenchymal cells: polymorphism associated with transformation of rough endoplasmic reticulum (2020)

To understand the behavior and function of bone-marrow mesenchymal cells (BMMCs), we overviewed the morphological presentation of BMMCs in bone-marrow granules (b-BMMCs), isolated BMMCs (i-BMMCs), and BMMCs (c-BMMCs) cultured in H4434 methylcellulose semisolid and MEM media. All samples were derived from bone-marrow aspirates of 30 patients with hematocytopenia. Light microscopy exhibited b-BMMCs and i-BMMCs characterized by abundant cytoplasm and irregular shape in bone-marrow smears, as well as c-BMMCs in culture conditions. Scanning electron microscopy demonstrated cultured c-BMMCs with a sheet-like feature enveloping hematopoietic cells. Transmission electron microscopy revealed b-BMMCs constructing a honeycomb-like structure by thin bifurcate processes among hematopoietic cells. Furthermore, i-BMMCs had bifurcate parapodiums on the surface and prominent rough endoplasmic reticulum (rER) connected with the plasmalemma of the parapodiums. The detailed images suggested that rER may serve as a membrane resource for plasmalemmal expansion in BMMCs in bone marrow.
Object Exploration By Purposive, Dynamic Viewpoint Adjustment (1992)

We present a viewing strategy for exploring the surface of an unknown object (i.e., making all of its points visible) by purposefully controlling the motion of an active observer. It is based on a simple relation between (1) the instantaneous direction of motion of the observer, (2) the visibility of points projecting to the occluding contour, and (3) the surface normal at those points: If the dot product of the surface normal at such points and the observer&apos;s velocity is positive, the visibility of the points is guaranteed under an infinitesimal viewpoint change. We show that this leads to an object exploration strategy in which the observer purposefully controls its motion based on the occluding contour in order to impose structure on the set of surface points explored, make its representation simple and qualitative, and provably solve the exploration problem for smooth generic surfaces of arbitrary shape. Unlike previous approaches where exploration is cast as a discrete process (i....
Inherently self-sterilizing charged multiblock polymers that kill drug-resistant microbes in minutes (2019)

To combat the growing global healthcare threat from drug-resistant pathogens, we demonstrate that midblock-sulfonated block polymers can kill 99.9999% of “superbugs,” including bacteria and viruses, in just 5 minutes due to an abrupt pH reduction.
The Formation of Wear-Induced Microstructures during Sliding Contact. (2008)

Abstract not provided.
Changes in Neuropeptide Y after Experimental Traumatic Brain Injury in the Rat (1992)

We utilized a model of fluid percussion (FP) brain injury in the rat to examine the hypothesis that alterations in brain neuropeptide Y (NPY) concentrations occur following brain injury. Male rats (n = 44) were subjected to FP traumatic brain injury. One group of animals (n = 38) was killed at 1 min, 15 min, 1 h, or 24 h after brain injury, and regional brain homogenates were analyzed for NPY concentrations using radioimmunoassay. A second group of animals (n = 6) was killed for NPY immunocytochemistry. Concentrations of NPY in the injured left parietal cortex were significantly elevated at 15 min post injury (p less than 0.05). No changes were observed in other brain regions. NPY-immunoreactive fibers were seen at 15 min post injury predominantly in the injured cortex and adjacent hippocampus. These temporal changes in NPY immunoreactivity, together with previous observations concerning posttraumatic changes in regional CBF in these same areas, suggest that an increase in region NPY concentrations after brain injury may be involved in part in the pathogenesis of posttraumatic hypoperfusion.
Evolutionary and Functional Features of Copy Number Variation in the Cattle Genome1 (2016)

Genomic structural variations are an important source of genetic diversity. Copy number variations (CNVs), gains and losses of large regions of genomic sequence between individuals of a species, have been associated with a wide variety of phenotypic traits. However, in cattle, as well as many other species, relatively little is understood about CNV, including frequency of CNVs in the genome, sizes, and locations, chromosomal properties, and evolutionary processes acting to shape CNV. In this work, we focused on copy number variation in the bovine genome, with the aim to detect CNVs in <i>Bos taurus</i> coding sequence and explore potential evolutionary mechanisms shaping these CNV. We identified and characterized CNV regions by utilizing exome sequence from 175 influential sires used in the Germplasm Evaluation project, representing 10 breeds. We examined various evolutionary and functional aspects of these CNVs, including selective constraint on CNV-overlapped genes, centrality of CNV genes in protein-protein interaction networks, and tissue-specific expression of CNV genes. Patterns of CNV in the <i>Bos taurus</i> genome reveal that reduced functional constraint and mutational bias may play a prominent role in shaping this type of structural variation.
esign of ultiwaveleng Optical unieation Systems Based on an veguide Ampli er Compensator (1996)

Abstruct- We theoretically analyze the performance of longhaul multichannel optical communication systems based on an integrated WDM power level compensator. By placing an array of Er3+-Yb3+ co-doped silica waveguides in parallel between a demultiplexer/multiplexer pair and preceeding it by an EDFA, we demonstrate the possibility of transmitting eight unequally spaced WDM channels over long distances, without electronic regenerators and using span lengths as high as 50 Km. This technique allows substantial reduction of both four-wave mixing crosstalk and gain peaking.
Repair of Zygomaticomalar Complex Fractures (1999)

The zygomaticomalar complex fracture, also known as the trimalar, tripod, or tetrapod fracture, is a fracture commonly encountered by facial plastic surgeons. Failure to correctly reduce these fractures can lead to facial asymmetry, trismus, diplopia, enophthalmos, and parasthesias. Approaches to the zygomaticomalar complex have been well documented in the literature and include the transconjunctival lateral canthotomy, subciliary blepharoplasty, brow, gingivobuccal, and coronal incisions, or some combination thereof. Fracture fixation is accomplished by the internal placement of miniplates and microplates across properly reduced fracture lines to resist torsional rotation and masticatory distraction. The method of fracture reduction and fixation employed at the University Hospital of Bern, Switzerland, shares much with previously published and accepted methods of medial and lateral buttress reconstruction, but it introduces several original concepts in an attempt to maximize functional and aesthetic outcomes.
The Epstein–Barr virus and post‐transplant lymphoproliferative disease: interplay of immunosuppression, EBV, and the immune system in disease pathogenesis (2001)

Transplant patients are at particular risk for developing post-transplant lymphoproliferative disease (PTLD) following administration of immunosuppressive therapy. In many cases the PTLD lesions express Epstein-Barr virus (EBV) latent and lytic genes as well as elevated levels of host cytokines. An outline of the potential contributions of EBV, host cytokines and T cells, and the immunosuppressive cyclosporine A, tacrolimus, and anti-CD3 antibody in the mechanism and pathogenesis of this disease is presented and discussed.
Effect of DuP 753, a Nonpeptide Angiotensin II Receptor Antagonist, on the Drinking Responses to Acutely Administered Dipsogenic Agents in Rats (1992)

The present studies examine the effect of the nonpeptide angiotensin II (AII) type 1 receptor antagonist, DuP 753, on water intake in rats treated with dipsogenic stimuli, which are thought to induce drinking via release of renin and subsequent formation of AII. Subcutaneous administration of DuP 753 in doses that are known to inhibit drinking induced by AII failed to inhibit the water intake of rats following subcutaneous administration of the beta-adrenoceptor agonist isoproterenol. The peptide antagonist1 Sar, 8Ileu-AII, which blocks both AII type 1 and AII type 2 receptors, also failed to inhibit isoproterenol-induced drinking, suggesting that neither subtype is involved in this drinking response. Additional studies verified previous reports that acute subcutaneous administration of both the beta-adrenoceptor antagonist propranolol and the angiotensin I-converting enzyme inhibitor captopril could block the drinking response to subcutaneous administration of isoproterenol. Subcutaneous administration of DuP 753 also failed to inhibit the drinking responses to subcutaneous administration of serotonin, 5-hydroxytryptophan, hypertonic saline, and polyethylene glycol. However, central intraventricular administration of DuP 753 inhibited the drinking response to subcutaneous administration of isoproterenol. The results are discussed in terms of the importance of AII in mediating isoproterenol-, serotonin-, and 5-hydroxytryptophan-induced water intake and suggest a need to readdress this mechanism.
New superior assembly technologies for modules with highest power densities (2010)

Power module development is striving for higher power densities, not only in new but also in already established packages. Two main challenges for such kinds of upgrades are to meet the increased requirements towards ampacity and heat dissipation. These new requirements may enforce adjustments in the utilized packaging technologies to overcome the given package limitations. The current article investigates the challenges of increased power densities in existing module packages and how they can be mastered.
Polymorphism of cephaloridine (1968)

Abstract Infrared spectra of Nujol mulls and X-ray powder photographs have shown that cephaloridine can exist in at least six different crystalline forms. The preparation, interconversion and properties of these forms are discussed. Proton magnetic resonance spectroscopy has been used to check their chemical identity.
Flexibele en niet-reguliere arbeid in Vlaamse organisaties : een eigentijdse blik (2004)

status: Published
The Synthesis of sym-Diaminotetrazine<sup>1a,1b</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of sym-Diaminotetrazine1a,1bChao-Han Lin, Eugene Lieber, and Jerome P. HorwitzCite this: J. Am. Chem. Soc. 1954, 76, 2, 427–430Publication Date (Print):January 1, 1954Publication History Published online1 May 2002Published inissue 1 January 1954https://pubs.acs.org/doi/10.1021/ja01631a031https://doi.org/10.1021/ja01631a031research-articleACS PublicationsRequest reuse permissionsArticle Views515Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
III—The Tariff and the Depression (1931)

Essay| July 01 1931 III—The Tariff and the Depression Julius Klein Julius Klein Assistant Secretary of Commerce Search for other works by this author on: This Site PubMed Google Scholar Current History (1931) 34 (4): 497–499. https://doi.org/10.1525/curh.1931.34.4.497 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Julius Klein; III—The Tariff and the Depression. Current History 1 September 1931; 34 (4): 497–499. doi: https://doi.org/10.1525/curh.1931.34.4.497 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1931 by The Regents of the University of California1931 Article PDF first page preview Close Modal You do not currently have access to this content.
INHIBITION OF TAP ROOT ELONGATION IN CONTAINERS BY SIX DIFFERENT MATERIALS COATED WITH SPIN OUT™ (1994)

Tap roots of two coarse rooted species, Nyssa sylvatica and Quercus acutissima, were subjected to six treatment materials which were cut to fit or placed on the bottom of a 7.61 container. Each treatment material (paint only, Styrofoam plug tray, 3M floor buffer mat, peat fiber sheet, stone and weed barrier fabric) was either painted with Spin Out™ of impregnated with Spin Out™ WP. Treatments that allowed the tap root to penetrate the material, i.e. weed barrier fabric, stone and 3M floor buffing mat, were more effective in controlling tap root elongation. The weed barrier fabric significantly reduced tap root length of Quercus acutissima and Nyssa sylvatica by 80% and 67% respectively compared to controls and by 65% and 53% respectively compared to the paint only treatment. In some cases the 3M and stone treatments were more effective than the weed barrier fabric but were impractical because of weight or expense.
Prova de Correção de Mecanismos de Controle de Coerência em Multiprocessadores (1990)

Em ambientes multicache, cada processador tem a ele associado uma memória cache privada, utilizada no armazenamento de dados provenientes da memória global. A consistência entre as cópias de um dado, que em um determinado momento pode existir em mais de uma memória cache, e o dado armazenado na memória global é garantida por um mecanismo de controle de coerência, que pode variar de multiprocessador para multiprocessador. Neste artigo nós propomos uma metodologia de prova de correção de mecanismos de controle de coerência para ambientes multicache orientados a barramento.
Randomized study of individualized induction therapy with or without VCR, and of maintenance of 4 or 12 courses in adult AML: JALSG-AML87. Japan Adult Leukemia Study Group (JALSG). (1992)

We asked 2 questions in this study. First was the additional effect of VCR in induction therapy, and the second was the duration of maintenance therapy. Adult AML were treated by an individualized response-oriented induction therapy with behenoyl Ara-C 200 mg/m2 daily + 6MP 70 mg/m2 daily + prednisolone 40 mg/m2 on days 1-4 + DNA 40 mg/m2 on days 1-3 and additionally on days 7, 8, 11, 12 (for M3, DNR 50 mg/m2 daily) (BHAC-DMP) until bone marrow became severely hypoplastic with less than 5% of blasts. Patients were randomized to BHAC-DMP or BHAC-DMP + VCR 0.35 mg/m2 on days 1-4. After obtaining CR, 3 courses of intensive consolidation therapy were given together with I.T. MTX+Ara-C+PSL. Maintenance intensification therapy was randomized to either 4 or 12 courses given every 2 months. Patients of age greater than or equal to 60 received about 2/3 reduced doses. From June 1987 to Sept. 1989, 265 consecutive adult AML were registered from 19 institutions and 258 were evaluable. Age ranged from 15 to 79 (med., 48). Out of 258, 200 (77.5%) achieved CR (80% in 209 of age less than 60 and 65% in 49 of age greater than or equal to 60). Unexpectedly, addition of VCR reduced the high CR rate of BHAC-DMP significantly (84% to 70%, p = 0.007). At the median follow-up of 37 mo., overall survival is 37%, and event-free survival (EVS) 27%. Survival, continuing CR and disease-free survival (DFS) rates of 200 CR cases are 45%, 40% and 35%, respectively. Patients received 12 courses of maintenance therapy showed better DFS (P = 0.0555). The VCR group had significantly worse EFS. By multivariate analysis, significant prognostic factors for the achievement of CR were age less than 60, PS 0-2 and no addition of VCR. Significant factors for longer DFS were induction of CR by one course, FAB M3 or M5 and age less than 50. The present multi-institutional study confirmed the high CR rates of the response-oriented individualized therapy reported from several centers in Japan, but failed to support an additional effect of VCR reported from one center.
Product enantioselectivity in the microsomal epoxide hydrolase catalyzed hydrolysis of 10,11-dihydro-10,11-epoxy-5H-dibenzo[a,d]cycloheptene (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProduct enantioselectivity in the microsomal epoxide hydrolase catalyzed hydrolysis of 10,11-dihydro-10,11-epoxy-5H-dibenzo[a,d]cyclohepteneG. Bellucci, G. Berti, C. Chiappe, F. Fabri, and F. MarioniCite this: J. Org. Chem. 1989, 54, 4, 968–970Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/jo00265a044https://doi.org/10.1021/jo00265a044research-articleACS PublicationsRequest reuse permissionsArticle Views279Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Hybrid Asymptotic‐Numerical Study of a Model for Intracranial Pressure Dynamics (1995)

Lumped parameter, compartmental models of the human intracranial system are studied through development of a hybrid asymptotic‐numerical technique. Dimensionless variables are introduced so that disparate time scales can be identified, and analysis shows that the system of model equations varies over both a fast and a slow time scale. On the fast time scale, the 5 × 5 system of equations may be decoupled to give a reduced 3 × 3 system combined with two conservation laws for the cerebrospinal fluid and brain compartmental volumes, respectively. The stiffness condition of the reduced system is shown to be considerably improved over that of the original system. For the general nonlinear problem, a uniformly valid asymptotic approximation for large time is derived by a hybrid asymptotic‐numerical technique. In the special case of the linear problem, where compliances and resistances are assumed to be constants, the uniform approximation for large time is obtained analytically. To verify accuracy, both asymptotic and hybrid asymptotic‐numerical results are compared with direct numerical integration of the full system. Physiological interpretations of the results are also given.
Quantification of Pulmonary Blood Flow and Volume in Healthy Volunteers by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Parallel Imaging Technique (2004)

If an adequate amount of gadodiamide and fast MR sequences are used, quantification of pulmonary blood flow and volume is feasible.