gebhart/patrepeval huggingface dataset:
Identification and Characterization of Novel Airway Epithelial Integrins (1993)

Integrins are heterodimeric glycoproteins that mediate cell-to-matrix and some cell-to-cell interactions. Recent evidence underscores the important roles of these receptors in signaling machines that transduce positional information into complex changes in cell behavior. As such, integrins have been shown to play critical roles in cell growth, differentiation, and migration. Most cells express multiple members of this family, but the integrin repertoire of any given cell appears to be highly tissue- and cell-type-specific. We have used the homology-based polymerase chain reaction to identify known and novel integrin subunits in airway epithelial cells. With this technique we have identified three novel integrin subunits that participate in the formation of at least four novel integrin heterodimers. The best characterized of these, alpha v beta 6, is a receptor for the extracellular matrix protein fibronectin, and appears to be expressed only in terminally differentiated mucosal epithelial cells. The novel alpha subunit, alpha 9, forms a heterodimer with the known beta subunit, beta 1, in some epithelial cell lines. Elucidatation of the specific roles these receptors play in airway health and disease will likely provide unique insights into both the biology of integrins and the biology of the airway epithelium.
A Case of Primary Adenosquamous Carcinoma of the True Vocal Fold Mimicking Atypical Squamous Cell Proliferation (2016)

Adenosquamous carcinoma (ASC) of the larynx is very rare malignancy which has well defined two distinctive pathological features, an adenocarcinoma and a squamous cell carcinoma (SCC). Diagnosis of ASC by endoscopic biopsy is challenging due to small amount of harvested tissue. ASC has a worse prognosis than SCC with an early lymph node metastasis and a distant dissemination. We experienced a rare case of vocal fold ASC which was initially misdiagnosed as atypical squamous cell proliferation at frozen biopsy. We reported this case with a literature review.
Plastid Targeting of Polyhydroxybutyrate Biosynthetic Pathway in Tobacco (2001)

Poly[(R)-(−)-3-hydroxyalkanoate] (PHA) synthase from Aeromonas caviae FA440 and β-ketothiolase and acetoacetyl-CoA reductase from Ralstonia eutropha H16 were targeted into tobacco plastid by utilizing a plastid-targeting signal peptide derived from the tomato ribulose-bisphosphate carboxylase (Rubisco) small subunit. The resulting tansgenic tobacco plant expressed all of the introduced genes, and GC-MS analysis of chloroform extract of tobacco leaves demonstrated that the transgenic plant produced poly[(R)-(−)-3-hydroxybutyrate] (PHB). The productivity of PHB in plastids was about 100-fold greater than that in cytoplasm without any apparent deleterious effects on growth and seed production. Intracellular localization of PHB in the leaf of the transgenic plant was examined under epifluorescence microscopy after Nile blue A staining, and it was proven that PHB is formed in chloroplasts around the inside of cell walls.
DESENVOLVIMENTO DE DISPOSITIVOS MÉDICOS: VANTAGENS DE UMA METODOLOGIA DEDICADA (2011)

No que diz respeito a complexidade, o sector dos dispositivos médicos é semelhante ao da indústria aeronáutica ou nuclear. Para tal, contribuiu a abrangência da definição do termo ‘dispositivos médicos’, a multiplicidade de regulamentos, directivas e normas e também a natureza da relação entre produtores e utilizadores. Neste contexto, a incerteza associada ao desenvolvimento de novos produtos e/ou serviços é elevada justificando a aplicação de metodologias dedicadas eficientes. De um modo geral, a utilização de métodos apropriados para o desenvolvimento de produtos permite reduzir a duração das tarefas, optimizar os recursos existentes e obter produtos de qualidade superior que satisfazem os utilizadores e, consequentemente, conduzem a lucros acrescidos para os seus produtores. No que diz respeito a dispositivos médicos, crê-se que a utilização de uma metodologia dedicada é essencial para ultrapassar as dificuldades impostas pela complexidade da indústria e até ganhar competitividade. O processo de desenvolvimento de produto envolve as seguintes etapas: identificação de uma oportunidade, voz do cliente, desenvolvimento de conceitos, design, teste e validação e lançamento. Neste artigo, as especificidades dos dispositivos médicos são identificadas e a legislação relevante é revista. Tendo em atenção a informação recolhida, é sugerida uma metodologia de desenvolvimento de produto dedicada aos dispositivos médicos na qual se dá especial atenção às primeiras etapas por ser durante essa altura que são tomadas decisões que afectam não só o desenvolvimento do produto / serviço mas também o seu preço e a aceitação pelos utilizadores.
Computing Approximating Automata for a Class of Hybrid Systems (2000)

This paper presents a new algorithm for generating finite-state automata models of hybrid systems in which the continuous-state dynamics can be switched when the continuous-state trajectory generates threshold events. The automata state transitions correspond to threshold events and the automata states correspond to portions of the threshold surfaces in the continuous state space. The hybrid system dynamics are approximated by the automata models in the sense that the languages of threshold event sequences generated by the automata contain the threshold event language for the hybrid system. Properties of the algorithm for constructing and refining the approximating automata are demonstrated and the application of approximating automata for system verification is illustrated for a switching controller for an inverted pendulum. Relationships to other approaches to hybrid system synthesis and verification are also discussed.
ChemInform Abstract: SYNTH. VON 1‐(P‐DIMETHYLAMINO‐PHENYL)‐2‐BROM‐2‐NITRO‐AETHYLEN (1970)

Abstract Die durch Bromierung von p‐Dimethylamino‐β‐nitro‐styrol dargestellte Dibromverbindung (I) zerfällt unter HBr‐Eliminierung zum Äthylen (II) (Ausbeute 52%) und nicht wie von Worall und Cohen (1944) angegeben, zu p‐ D1methylammo‐a‐brom‐β‐nitro‐styrol.
Architectural characterization of an XML-centric commercial server workload (2004)

As XML (extensible markup language) rapidly emerges as the standard for information storage and communication, it becomes increasingly important to understand its architectural characteristics and performance implications. In This work, our goal is to characterize a representative XML-based server in a managed runtime environment such as Java. Based on detailed measurements on an Intel/spl reg/ XeonTM processor-based commercial server running a real-world XML-based server workload, we start by looking at symmetric multiprocessor (SMP) scaling characteristics and the benefits of hyper-threading technology. Using performance monitoring events provided on the processor, we present an overview of the architectural characteristics (such as clocks per instruction (CPI), cache miss rates, memory/bus utilization, branch behavior and efficiency). Using profiling tools like Intel/spl reg/ VTuneTM performance analyzer, we map these architectural/performance characteristics to the various components of application execution - helping us identify hot spots and propose potential enhancements to code generation and application software. We believe that the information presented Are useful in understanding the XML processing characteristics and may serve as a useful first step to identifying potential hardware/software optimizations for improved future performance.
Evaluation of Fourier Transform Near-Infrared for the Simultaneous Analysis of Light Alkene Mixtures (1997)

A Fourier transform near-infrared (FT-NIR) spectrometer incorporating a fiber-optic-coupled sample cell was used for simultaneous determination of ethylene and monoalkylated light alkenes in liquid mixtures at room temperature and pressure. Ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 1-octene, and 1-decene were selected for the evaluation. Several additional alkylated alkenes (e.g., 1,1 dialkylated, cis, trans dialkylated, and trialkylated alkenes) were investigated to determine the effects of the molecular structure on this determination. The first overtone of the asymmetric =CH 2 stretch of the monoalkylated alkenes was found to be unique for the light alkenes in the NIR region. This region of the spectrum was used for quantitative analysis using classical least-squares (CLS) regression. Ethylene/1-octene mixtures were studied as an example. The concentrations of these alkenes were determined with an error of less than 1% by weight.
Optimisation de la qualité de service par l'utilisation de mémoire cache (2013)

International audience
Simulated allocation: a suboptimal solution to the multicommodity flow problem (1994)

The paper discusses a stochastic approach to multicommodity flow problems, whose idea comes from simulation of alternative call routing in circuit-switched networks. The proposed method can be used to find suboptimal solutions for a vast class of integer-valued multicommodity flow problems. The preliminary results illustrate the effectiveness of the method in application to reconfiguration of mesh SDH transmission networks.
Propagation of nonlinear waves in waveguides and application to nondestructive stress measurement (2012)

Propagation of nonlinear waves in waveguides is a field that has received an ever increasing interest in the last few decades. Nonlinear guided waves are excellent candidates for interrogating long waveguide like structures because they combine high sensitivity to structural conditions, typical of nonlinear parameters, with large inspection ranges, characteristic of wave propagation in bounded media. The primary topic of this dissertation is the analysis of ultrasonic waves, including ultrasonic guided waves, propagating in their nonlinear regime and their application to structural health monitoring problems, particularly the measurement of thermal stress in Continuous Welded Rail (CWR). Following an overview of basic physical principles generating nonlinearities in ultrasonic wave propagation, the case of higher-harmonic generation in multi-mode and dispersive guided waves is examined in more detail. A numerical framework is developed in order to predict favorable higher-order generation conditions (i.e. specific guided modes and frequencies) for waveguides of arbitrary cross-sections. This model is applied to various benchmark cases of complex structures. The nonlinear wave propagation model is then applied to the case of a constrained railroad track (CWR) subjected to thermal variations. This study is a direct response to the key need within the railroad transportation community to develop a technique able to measure thermal stresses in CWR, or determine the rail temperature corresponding to a null thermal stress (Neutral Temperature - NT). The numerical simulation phase concludes with a numerical study performed using ABAQUS commercial finite element package. These analyses were crucial in predicting the evolution of the nonlinear parameter [Beta] with thermal stress level acting in the rail. A novel physical model, based on interatomic potential, was developed to explain the origin of nonlinear wave propagation under constrained thermal expansion. In fact, where the classical physics of nonlinear wave propagation assumes finite strains, the case at hand of constrained thermal expansion is, instead, characterized by infinitesimal (ideally zero) strains. Hand-in-hand with the theoretical analyses, a comprehensive program of experimental testing has been conducted at UCSD's Large-Scale Rail NT Test-bed, a unique 70-ft track with controlled temperature excursions constructed at UCSD's Powell Laboratories with government and industry funding. A prototype has been constructed for wayside determination of the rail NT based on the measurement of wave nonlinearities. The experimental results obtained with the prototype in the Large-Scale Test-bed are extremely encouraging, showing an accuracy of only a few degrees for the determination of the rail NT. If confirmed in the field, this result could revolutionize the way CWR are maintained to prevent rail buckling with respect to the thermal stress management problem
SEM study of cytoskeleton of osteoblasts immobilized on HA-ceramic during biocompatibility testing (1992)

Some standards for biocompatibility testing of biomaterials requires the determination of the cytoskeleton aspect of differentiated cells in contact with the material. It is usually determined by indirect immunofluorescence staining of cytoskeleton proteins and examination with a light microscope. This examination is difficult on non transparent material and the resolution is very poor. In order to study the interaction of osteoblast cytoskeleton with HA-macroporous ceramics, we grew chicken embryo osteoblasts on the material then we extracted cell membranes to expose the cytoskeleton proteins. They were then examined in SEM.
The Burden of Fungal Diseases in Romania (2018)

Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.23% of Romanians suffer from a serious form of fungal disease.
Structure, conductivity, and electron spin resonance of tetrathiafulvalene 11,11,12,12-tetracyanonaphtho-2, 6-quinodimethane (TTF)(TNAP) (1975)

Crystals of tetrathiafulvalene 11,11,12,12-tetracyanonaphtho-2, 6-quinodimethane (TTF)(TNAP), obtained via a slow diffusion process from acetonitrile solution are triclinic with uniform, segregated stacks of cation and anion radicals. The electrical conductivity near room temperature is 40 ${\mathrm{ohm}}^{\ensuremath{-}1}$ ${\mathrm{cm}}^{\ensuremath{-}1}$ and shows little temperature dependence. At 185 K there is a sharp drop in conductivity and at lower temperatures the conductivity is activated with an energy 0.1 eV. The spin susceptibility and $g$ tensor show temperature dependences in relation to the transition similar to those exhibited by tetrathiafulvalene-tetracyanoquinodimethane (TTF)(TCNQ). No evidence for a Peierls distortion was obtained from x-ray diffraction studies at 150 K.
From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application (2018)

Radiolabeled amino acids, their derivatives and peptides have a broad scope of application and can be used as receptor ligands, as well as enzyme substrates for many different diseases as radiopharmaceutical tracers. Over the past few decades, the application of molecular imaging techniques such as positron emission tomography (PET) has gained considerable importance and significance in diagnosis in today's advanced health care. Next to that, the availability of cyclotrons and state-of-the-art radiochemistry facilities has progressed the production of imaging agents enabling the preparation of many versatile PET radiotracers. Due to many favorable characteristics of radiolabeled amino acids and peptides, they can be used for tumor staging and monitoring the progress of therapy success, while aromatic amino acids can be employed as PET tracer to study neurological disorders. This review provides a comprehensive overview of radiosynthetic and enzymatic approaches towards carbon-11 amino acids, their analogues and peptides, with focus on stereoselective reactions, and reflects upon their clinical application.
Hierarchical error diagnosis targeting RTL circuits (2002)

Diagnosis algorithms targeting design errors in RTL circuit descriptions are presented in this paper. The algorithms presented exploit the hierarchy available in RTL designs to locate design errors. Xlists are shown to be useful to capture the effects of design errors within components of RTL designs. Information from the simulation of Xlists is used to systematically diagnose components in error. Experiments are performed on RTL benchmark circuits using a prototype that we have developed to demonstrate the rapid and accurate location of errors. They also show that diagnosis at the RTL offers a significantly superior alternative to diagnosis at the gate-level both in terms of diagnostic accuracy and computational efficiency.
Platelet and fibrinogen kinetics in the chronic myeloproliferative disorders (1972)

Simultaneous platelet and fibrinogen survival kinetic studies utilizing 75Seselenomethionine was performed on six patients with chronic myelogenous leukemia (CML), four with polycythemia vera (PV), one with idiopathic thrombocytosis (IT), and seven with myelofibrosis and myeloid metaplasia (MMM). The data revealed that platelet survivals, as well as fibrinogen survivals, were increased in CML as compared to patients with the other myeloproliferative disorders (MPD). Platelet survival was shortened in the patients with MPD as compared to the control patients. Thrombotic episodes were noted in three patients with MPD, while another had recurrent rectal bleeding. In all of these patients, platelet turnover was increased and was the only consistent determinant of hemostatic abnormality. Platelet adhesiveness and aggregation studies were inconsistently altered in any group and were not useful predictors of the risk of hemorrhagic or thrombotic diathesis. The data suggest that the platelets produced by patients with CML are functionally abnormal and underutilized when compared to control patients and to patients with other MPD. The thrombocytosis of CML results from decreased platelet utilization rather than from overproduction. Overutilization of platelets in patients with other MPD contributes to the thrombotic tendency noted in these patients. These results suggest another distinctive feature which separates CML from the other MPD. Platelet and fibrinogen kinetic studies are important in evaluating the pathophysiology of the thrombocytopenia or thrombocytosis of the myeloproliferative diseases as well as in investigating the physiology of hemostasis.
ATOMIC FORCE MICROSCOPY OF COMPLEX DNA KNOTS (2005)

Capítulo en: Jorge A. Calvo; Kenneth C. Millett; Eric J. Rawdon; Andrzej Stasiak (eds.). Physical and Numerical Models in Knot Theory: Including Applications to the Life Sciences. New Jersey: World Scientific, 2005, p.161-170. (Series on Knots and everything ; 36). ISBN 9812561870. ISBN: 978-981-256-187-9 . ISBN: 978-981-4480-85-7
Stimulation of Nonimmunized Lymphocytes by Platelet-Antibody Complexes in Idiopathic Thrombocytopenic Purpura (1973)

Abstract Platelets preincubated in serum from patients with immunologic thrombocytopenia stimulate autologous lymphocytes in culture. Stimulation of new deoxyribonucleic acid synthesis by cultured lymphocytes was measured by the uptake of tritiated thymidine. The lymphocyte-stimulating activity in serum was heat stable, could be adsorbed by autologous and homologous platelets, was inhibited by anti-human immunoglobulin G, and chromatographed as immunoglobulin G on diethylaminoethyl cellulose. The degree of stimulation was proportional to the number of platelets in each culture and was maximal on the sixth day of culture. With this technic, presumptive antibody was detected in 25 of 26 patients with idiopathic thrombocytopenic purpura and eight of nine with other types of immune thrombocytopenia. The lymphocyte-stimulating activity in idiopathic thrombocytopenic purpura persisted after clinical remission induced by steroids, splenectomy or cyclophosphamide therapy. Normal lymphocytes thus appear to be nons...
A new approach to bicyclomycin (1986)

I. M. Dawson, J. A. Gregory, R. B. Herbert and P. G. Sammes, J. Chem. Soc., Chem. Commun., 1986, 620 DOI: 10.1039/C39860000620
Design of a Steerable Two-beam System for Simultaneous On- and Off-axis Imaging with GUFI (2008)

The GUFI (Galway Ultra Fast Imager) has been primarily developed for high throughput differential photometry, in order to study variability in challenging circumstances, such as near bright sources or within crowded fields. The instrument features a low light level charged coupled device (L3‐CCD) that enhances detector speed and sensitivity but only covers small fields of view. This presents limitations on possible science targets when suitable differential photometry comparison stars are not in the immediate vicinity of the target. Conventional solutions for imaging larger portions of sky without sacrificing SNR include telescope focal reduction methods and large arrays of CCDs. Our alternative solution entails a two‐path, ‘outrigger’ optical design to image target and comparison stars separately. This new approach allows detection of variable targets that formerly were not reachable with smaller‐field detectors. The mechanical design was originally generated with AutoCAD® drafting software before being compiled in, and vetted with an OSLO® optical design package. Through filters B, V and I, the limiting design aberration was chromatic focal shift that appeared most severe in the B‐filter's bandpass range. However, the degree of image blurring caused by this aberration and others did not exceed the scale of that already produced by atmospheric turbulence. For each bandpass, the model's imaging performance met and exceeded expectations set by all design constraints.
Effects of oxygen pressure on liquid-phase autoxidation of hexadecane at 160 to 190 degree C (1987)

Investigations of the liquid phase autoxidation of hexadecane with pure oxygen carried out in the stirred flow microreactor at 100 to 110 kPa O{sub 2} and 120 to 180{degree}C led to the discoveries of {alpha}, and {alpha}, {xi} intramolecular hydrogen abstraction reactions of alkylperoxy radicals and the cleavage reaction of {alpha}, {gamma} -hydroperoxyketones. The occurrence of intramolecular hydrogen abstraction reactions explained the formation of difunctional oxidation products, namely {alpha}, {gamma} and {alpha}, {xi} dihydroperoxides and hydroperoxy substituted ketones, which, together with monohydroperoxides, are the major primary oxidation products at these reaction conditions. The cleavage product formation. It accounted for the formation of cleavage methyl ketones and 50-60% of alkanoic acids. The formation of remaining cleavage products was explained by a complex sequence of reactions which was started by {beta}-scission and intramolecular hydrogen abstraction reactions of alkoxy radicals. In the present study we describe the effects of oxygen pressure on kinetics and mechanisms of hexadecane autoxidation at elevated temperatures. The range of oxygen pressures studied was 4-120 kPa which includes atmospheric conditions.
Consistency of MGEX Orbit and Clock Products (2019)

The analysis centers of the Multi-GNSS Pilot Project of the International GNSS Service provide orbit and clock products for the global navigation satellite systems (GNSSs) Global Positioning System (GPS), GLONASS, Galileo, and BeiDou, as well as for the Japanese regional Quasi-Zenith Satellite System (QZSS). Due to improved solar radiation pressure modeling and other more sophisticated models, the consistency of these products has improved in recent years. The current orbit consistency between different analysis centers is on the level of a few centimeters for GPS, around one decimeter for GLONASS and Galileo, a few decimeters for BeiDou-2, and several decimeters for QZSS. The clock consistency is about 2 cm for GPS, 5 cm for GLONASS and Galileo, and 10 cm for BeiDou-2. In terms of carrier phase modeling error for precise point positioning, the various products exhibit consistencies of 2–3 cm for GPS, 6–14 cm for GLONASS, 3–10 cm for Galileo, and 10–17 cm for BeiDou-2.