gebhart/patrepeval huggingface dataset:
The Dorsal Skin-Flap Model in the Rat (1993)

Several authors have postulated that the standard McFarlane-type dorsal rat flap model can survive as a graft. Therefore, in an effort to better understand the metabolic support governing the survival of this flap, five flap designs on the dorsal surface of the rat were studied. Each was manipulated to control progressively for the metabolic support to the flap by means of skin-graft and/or skin-flap physiology. The flap designs included (1) a standard McFarlane flap (n = 10), (2) a full-thickness "flap" graft (n = 10), (3) a McFarlane flap separated from the bed with plastic sheeting (n = 9), (4) a McFarlane flap separated from the bed by closing the wound beneath the flap (n = 29), and (5) flaps raised as in group 4 after a 2-week delay procedure (n = 9). Based on direct comparisons of both the pattern of necrosis and the surviving surface area in each group, we conclude that (1) the distal aspect of the dorsal rat flap can survive as a graft when in contact with the underlying bed, (2) the "take" of the flap as a graft is variable, and (3) to serve as a reasonable indicator of human flap behavior, the skin-graft effect must be controlled for by separating the flap from the underlying bed.
A new method for information retrieval, based on the theory of relative concentration (1989)

This paper introduces a new method for information retrieval of documents that are represented by a vector. The novelty of the algorithm lies in the fact that no (generalized) p-norms are used as a matching function between the query and the document (as is done e.g. by Salton and others) but a function that measures the relative dispersion of the terms between a document and a query. This function originates from an earlier paper of the author where a good measure of relative concentration was introduced, used in informetrics to measure the degree of specialization of a journal w.r.t. the entire subject. This new information retrieval algorithm is shown to have many desirable properties (in the sense of the new Cater-Kraft wish list) including those of the original cosine-matching function of Salton. In addition the property of the cosine-matching function that, if one only uses weights 0 to 1, one is reduced to Boolean IR, is refined in the sense that one takes into consideration the broadness or specialization of a document and a query. Our new matching function satisfies these additional properties.
AniGraph-a data structure for computer animation (2002)

Rendering animations requires data structures which allow for an easy handling of the movements and changes in the scene. For a sophisticated renderer, it is very important to access the information describing the motion of the objects, because such knowledge can be used to reduce the render time. We describe an animation model based on an annotated graph, on definitions of dimensions and on implementations of functions. The data structure with its simple interfaces provides an easy to use instrument to produce computer animations. On the one hand, the model is almost independent from a static modeler and a final renderer, but on the other hand, it can be adapted easily to the needs of a specific project. In the current implementation an artist needs to work closely together with a programmer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Critical message scheduling for disaster response and recovery phases (2015)

During disaster especially response and recovery phases, limited bandwidths and high rate of incoming messages make communication network vital resources. Allocating bandwidth to send critical messages such as well-being statuses, assistant activities etc. can determine the effectiveness of the disaster responses as messages are numerous, duplicated, and often timely critical. In this paper, we use the combination of contextual information including importance, urgency, and uniqueness to schedule messages under extreme situations. The experiments show that our scheduler can vastly out-perform traditional schedulers. This can ensure that precious information during disaster response and recovery phases are effectively handled.
Oilseed pretreatment in connection with physical refining (1983)

Abstract Tests have shown that the nonhydratable phosphatides (NHP) arising by the action of phospholipases are not present in significant quantities in commercial soybeans, but that they are formed predominantly only during extraction. By a moisture‐heat treatment of the soy flakes prior to the extraction, this enzyme activity can be almost completely eliminated so that, during the subsequent extraction, an enzymatic change of the oil no longer occurs. In comparison with the extraction of untreated soy flakes, the yield of soy lecithin is doubled; the lecithin has a higher content of phosphatidylchol ine; the crude, degummed soy oil has extraordinarily low NHP contents; and the soy meal tastes less bitter.
Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels (1993)

We tested the hypothesis that prostacyclin and its stable analogue iloprost act as agonists of ATP-sensitive potassium channels (KATP) to induce vasodilation of the coronary circulation. The selective blocker of KATP, glibenclamide, was used as a probe for vasodilation mediated by KATP in saline-perfused rabbit hearts (constant flow, Langendorff preparation). Glibenclamide (10-300 nM) significantly increased coronary perfusion pressure and inhibited vasodilation induced by iloprost (1-30 nM), prostacyclin (10 nM), adenosine (0.3 microM), and cromakalim (0.1 microM), a known agonist of KATP. This potassium channel antagonist also inhibited vasodilation of rabbit hearts in response to 10 nM bradykinin in the presence of an inhibitor of nitric oxide synthase (30 microM NG-nitro-L-arginine). Because bradykinin-induced vasodilation is mediated by prostacyclin released from endothelial cells when nitric oxide synthesis is inhibited, these data indicate that glibenclamide is also effective against endogenous prostacyclin. The inhibitory effects of glibenclamide were selective: vasodilation induced by sodium nitroprusside (1-10 microM) or acetylcholine (1 microM) were not inhibited by this potassium channel antagonist. In addition, basal and bradykinin-stimulated release of 6-ketoprostaglandin F1 alpha was not affected by this antagonist of KATP. Glibenclamide also did not inhibit the activation of adenylate cyclase, as indicated by its lack of effect on adenosine 3',5'-cyclic monophosphate accumulation induced by iloprost (10 nM-1 microM) in bovine coronary arterial segments, a tissue in which iloprost-induced vascular smooth muscle relaxation is inhibited by glibenclamide.(ABSTRACT TRUNCATED AT 250 WORDS)
ChemInform Abstract: Catalytic Activity of Nd1‐xSrxCoO3‐y in the Oxidation of Carbon Monoxide. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions (2003)

Our past studies showed that Peyer's patches were required for the induction of oral tolerance to the protein antigen ovalbumin (OVA), but not to the hapten 2,4,6-trinitrobenzene sulfonic acid (TNBS). In the present study, the effects of immunosenescence on oral tolerance induction were assessed with these two toleragens. Significant reductions in OVA-specific serum IgG antibody and CD4(+) T cell responses to subsequent challenge were observed in OVA-fed, young adult mice. Importantly, these reduced anti-OVA antibody responses were associated with delayed-type hypersensitivity, and antigen-induced CD4(+) T(h)1- and T(h)2-type cytokine responses. On the other hand, aged mice fed OVA failed to develop oral tolerance. Thus, CD4(+) T cells from Peyer's patches produced selected T(h)2- but no T(h)1-type cytokines. The TNP-specific serum IgG antibody and T cell responses were significantly diminished by prior TNBS feeding in young adult, 6- to 8-month-old and 12- to 14-month-old, but not in senescent, 2-year-old mice. Finally, we have directly assessed dendritic cell subsets and T cell responses in Peyer's patches, and their function in tolerance induction was impaired at an earlier stage of life. These results suggest that lack of oral tolerance to the protein OVA during aging is the result of dysfunctional Peyer's patches.
Prothrombin Complex Concentrate Reverses the Anticoagulant Effect of Rivaroxaban In Healthy Volunteers. (2010)

Abstract Abstract 1094 Background: Rivaroxaban is a novel oral antithrombotic agent in the class of specific factor Xa inhibitors, and is licensed in Europe and Canada for the prevention of venous thromboembolism after elective orthopedic surgery. Despite its stable pharmacokinetic and pharmacodynamic profile, immediate reversal may be required in case of a major bleeding or emergency surgery. No specific antidote is currently available, although Prothrombin Complex Concentrate (PCC) seems effective in animal studies. This study is the first to investigate the ability of PCC to reverse the antithrombotic effect of Rivaroxaban in humans. Methods: In a randomized, double-blind, placebo-controlled trial, twelve healthy male subjects received Rivaroxaban 20mg twice daily for two and a half days. One group (n=6) was then randomized to receive a single bolus of 50 IU/kg PCC (Co-fact®, Sanquin, the Netherlands) while the other group (n=6) was given a similar volume of saline. Results: The prothrombin time (PT) was significantly prolonged by Rivaroxaban (15.8 sec ± 1.3 versus 12.3 ± 0.7 at baseline; p< 0.001). Immediately after the infusion of PCC, the PT normalised almost completely (12.8 ± 1.0; p< 0.001), which was sustained for 24 hours. Saline did not reverse the PT prolongation (16.2 ± 0.8; p= 0.4). Furthermore, Rivaroxaban inhibited the endogenous thrombin potential (ETP) (51% ± 22, baseline 92 ± 22; p= 0.002), with normalisation after administration of PCC (114 ± 26; p< 0.001), but not after saline (41 ± 6; p= 0.2). Conclusions: This study provides the first data that Prothrombin Complex Concentrate reverses the anticoagulant effect of Rivaroxaban in humans and may serve as an antidote for the new oral factor Xa inhibitors. Disclosures: Eerenberg: Sanquin Netherlands: Research Funding, make available of Prothrombin Complex Concentrate for this study. Kamphuisen:Sanquin Netherlands: Research Funding, make available of Prothrombin Complex Concentrate for this study. Levi:Sanquin Netherlands: Research Funding, make available of Prothrombin Complex Concentrate for this study.
The God in the Dew (1974)

A l'origine, le dieu grec Éros était la rosée. On décèle cette conception originelle dans la réalité littéraire, dans des peintures de vases, dans une comparaison des mythologies grecque et étrangères, et dans une étymologie possible du nom lui-même.
Uterine Health and Disorders (1997)

Nonspecific uterine infections reduce the reproductive efficiency of cows and the profit potential of dairy farms. Fortunately, most cows do not develop severe uterine infections. The term uterine infection indicates that the uterus is contaminated with pathogenic organisms. Actinomyces pyogenes, either alone or with other bacteria, is often associated with uterine infections. When A. pyogenes was isolated from uterine fluids after d 21 postpartum, cows developed severe endometritis and were infertile at first service. However, the exact causes of uterine infections are unknown but are associated with several factors. Cows with dystocia, retained placenta, twins or still-births, and various metabolic disorders are more likely to develop metritis than are other cows. Aberrant immune function before and after calving seems to predispose cows to severe uterine infections. Few cows die from uterine infections, but cows with uterine infections are more likely to be culled for poor reproductive performance. Also, uterine infections can reduce milk production, and some treatments contaminate milk. Because they are nonspecific, uterine infections are difficult to prevent; attention to sanitation and periparturient hygiene, especially during assisted calving, may be the best defense. Evidence that aberrant immuno function predisposes cows to uterine infections indicates that methods for regulating immune function in periparturient cows have the potential for preventing or treating uterine infections.
Photoreceptor Pigment for Blue Light in <i>Neurospora crassa</i> (1975)

Irradiating the mycelium of Neurospora crassa with moderate intensities of blue light causes a reversible photoreduction of a b-type cytochrome. The action spectrum for the photoreduction of cytochrome b is very similar to the absorption spectrum of flavin pigments. Prolonged irradiation of the mycelium with strong blue light irreversibly bleaches flavin-like pigments and as these pigments are bleached the photoresponse of cytochrome b is lost. We conclude from these and other data that a flavin is the photoreceptor pigment for the photoreduction of cytochrome b. The close similarity between the action spectrum for the photoreduction of cytochrome b and action spectra for a number of physiological photoresponses suggests that this photoreceptor pigment controls a wide variety of photobiological processes in a wide diversity of organisms.
Fault monitoring using neural networks (2003)

The author describes a method in which a neural network is used to model the relationship between two or more sensor outputs at a time when the component or system is known to be performing satisfactorily. The neural network is then used to predict one or more of the sensor signals using the other sensor signals as inputs. The predicted signal is then compared with the corresponding actual signal. If there is a significant difference (beyond normal statistical variations), then the relationship between the sensor signals has changed, indicating that something in the component has changed since the neural network was trained (i.e. since the component or system was working satisfactorily). Several industrial applications of this technique (especially in nuclear power plants) are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Sialic acid in rabbit lacrimal gland fluid. (1976)

To date, there has been no attempt to determine which of the orbital glands contribute the sialic acid, which has been found in tears and tear mucoids. In the present study, sialic acid was found in the fluid collected directly from the lacrimal gland excretory duct, uncontaminated by the secretions of the other orbital glands (Nictitans, Harderian, conjunctival) as well as in the fluid secreted into the conjunctival sac by the other orbital glands, uncontaminated by lacrimal gland fluid. At all flow rates, the rate of secretion of sialic acid increased as flow rate increased in both fluids and the rate of secretion of sialic acid by the lacrimal gland was three times that by the other orbital glands. This is the first demonstration that a substance, which can be derived from either nonserum glycoproteins, such as the tear mucoids, or alpha-globulins, is a component of the secretions of the lacrimal gland, as well as of the secretion of the other orbital glands.
Guided tissue regeneration for periodontal infra-bony defects (2006)

GTR has a greater effect on probing measures of periodontal treatment than open flap debridement, including improved attachment gain, reduced pocket depth, less increase in gingival recession and more gain in hard tissue probing at re-entry surgery. However there is marked variability between studies and the clinical relevance of these changes is unknown. As a result, it is difficult to draw general conclusions about the clinical benefit of GTR. Whilst there is evidence that GTR can demonstrate a significant improvement over conventional open flap surgery, the factors affecting outcomes are unclear from the literature and these might include study conduct issues such as bias. Therefore, patients and health professionals need to consider the predictability of the technique compared with other methods of treatment before making final decisions on use. Since trial reports were often incomplete, we recommend that future trials should follow the CONSORT statement both in their conduct and reporting. There is therefore little value in future research repeating simple, small efficacy studies. The priority should be to identify factors associated with improved outcomes as well as investigating outcomes relevant to patients. Types of research might include large observational studies to generate hypotheses for testing in clinical trials, qualitative studies on patient-centred outcomes and trials exploring innovative analytic methods such as multilevel modelling. Open flap surgery should remain the control comparison in these studies.
Assessing in vivo dynamics of multiple quality attributes from a therapeutic IgG4 monoclonal antibody circulating in cynomolgus monkey (2016)

Characterization of biopharmaceutical proteins and assessment and understanding of the critical quality attributes (CQAs) is a significant part of biopharmaceutical product development and is routinely performed in vitro. In contrast, systematic analysis of the quality attributes in vivo is not as widespread, although metabolism and clearance of multiple variants of therapeutic proteins administered to non-human primates and human subjects may have a different impact on safety, efficacy and exposure. The major hurdles of such studies are usually sample availability and technical capability. In this study, we used affinity purification coupled with liquid chromatography and mass spectrometric analysis of the digested protein for consistent and simultaneous detection of the full amino acid sequence of a therapeutic IgG4 monoclonal antibody, MAB1. This methodology allowed us to assess in vivo changes of all sequence-related modifications and quality attributes of MAB1 over the duration of a preclinical pharmacokinetic study in cynomolgus monkeys.
Dynamic modeling and control design of DSTATCOM with ultra-capacitor energy storage for power quality improvements (2008)

This paper describes the dynamic modeling and the control design of a distribution static compensator (DSTATCOM) coupled with ultra-capacitor energy storage (UCES) for improving the power quality of power systems. Three modes of operation are considered, i.e. voltage control for voltage fluctuations ride-through, current/voltage harmonics mitigation and dynamic active power control. New models and control schemes are proposed. The control technique employed is based on the instantaneous power theory on the synchronous-rotating dq reference frame. Validation of models and control algorithms is carried out through simulations in SimPowerSystems of MATLAB/Simulink.
The LIFE study: the straw that should break the camel's back (2003)

In the LIFE study, the most recent landmark trial in hypertension,1–3 more than 9000 hypertensive patients were randomized to either a losartan-based regimen or to an atenolol-based regimen. Although less than 10% of all patients remained on monotherapy of either drug at the end of the study, patients in the losartan arm experienced a significantly better reduction in morbidity and mortality than patients in the atenolol arm. This reduction in morbidity and mortality was mostly driven by a stroke reduction since in the whole study population no significant difference in myocardial infarction (MI) was demonstrated between the two treatment arms. To be included into the study all patients had to have left ventricular hypertrophy (LVH) by electrocardiographic (ECG) criteria. More than three decades ago, based on ECG findings, Kannel et al.4 documented LVH to be a powerful blood pressure independent risk factor for cardiac events, such as acute MI, sudden death, congestive heart failure and strokes. Since these findings were at odds with prevalent textbook opinion, they were greeted with a great deal of skepticism. However, over the years, evidence started accumulating, not only from ECG studies, but also from echocardiographic studies, from Framingham and from other sources, showing clearly that the occurrence of LVH in hypertension had to be considered a strong and independent herald for cardiovascular morbidity and mortality.5–8 Conversely, a reduction in LVH with antihypertensive therapy has been shown to be associated with an improvement in outcome and to reduce the risk of cardiovascular morbidity and mortality. Indeed, data from several sources convincingly demonstrated that LVH was a more reliable and more powerful surrogate endpoint forcardiovascular fatal and non-fatal events than blood …
IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data (2003)

IMGT/3Dstructure-DB and IMGT/Structural-Query are a novel 3D structure database and a new tool for immunological proteins. They are part of IMGT, the international ImMunoGenetics information system, a high-quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species, which consists of databases, Web resources and interactive on-line tools. IMGT/3Dstructure-DB data are described according to the IMGT Scientific chart rules based on the IMGT-ONTOLOGY concepts. IMGT/3Dstructure-DB provides IMGT gene and allele identification of IG, TR and MHC proteins with known 3D structures, domain delimitations, amino acid positions according to the IMGT unique numbering and renumbered coordinate flat files. Moreover IMGT/3Dstructure-DB provides 2D graphical representations (or Collier de Perles) and results of contact analysis. The IMGT/StructuralQuery tool allows search of this database based on specific structural characteristics. IMGT/3Dstructure-DB and IMGT/StructuralQuery are freely available at http://imgt. cines.fr.
Accuracy of the FEF CO2 Detector in the Assessment of Endotracheal Tube Placement (1992)

The sensitivity and reliability of the FEF end-tidal CO2 detector were investigated for its suitability in the assessment of correct placement of an endotracheal tube. Sensitivity was determined by having eight blinded volunteers observe the color change in the FEF detector with the administration of different volumes and varying CO2 concentrations of gas mixture. The color change in the FEF detector was also assessed during esophageal ventilations before and after administration of carbonated beverage into the stomach of swine and during cardiopulmonary resuscitation in swine. An interpersonal variation was present among the blinded observers during the color-matching process. Different colors were observed with the same volume and CO2 concentration of gas mixture. During esophageal ventilations before or after the administration of carbonated beverage, the FEF detector was neither accurate nor rapid in identifying esophageal placement of the endotracheal tube. The "C" color was displayed during the initial six ventilations in one swine, and esophageal intubation would have been missed. The FEF detector could (by displaying a "C" color) identify one of six correctly intubated swine during cardiopulmonary resuscitation. In conclusion, the FEF CO2 detector does not have the characteristics to reliably assess the correct placement of an endotracheal tube.
Mechanics for Engineers: Statics and Dynamics (1987)

Mechanics for engineers: statics and dynamics , Mechanics for engineers: statics and dynamics , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی