gebhart/patrepeval huggingface dataset:
Stereotactic hypofractionated high-dose irradiation for stage I non-small cell lung carcinoma: Clinical outcomes in 273 cases of a Japanese multi-institutional study (2004)

7003 Background: Stereotactic hypofractionated irradiation (STI) has been actively performed for a radical treatment of stage I non-small cell lung cancer (NSCLC) in Japan. We sought to retrospectively evaluate Japanese multi-institutional results. Methods: From April 1993 to April 2003, 273 patients (age range 35–92, median 76 years) who had stage I (175 T1N0M0 and 98 T2N0M0) primary NSCLC (119 squamous cell, 125 adeno, and 29 others) were treated with hypofractionated high-dose STI in 14 institutions. Of the 273 patients, 169 (61.9%) were medically inoperable due to mainly chronic pulmonary disease or high-age. Tumor size ranged from 7 to 58 mm with a median of 28 mm. The stereotactic three-dimensional treatment was performed using non-coplanar dynamic arcs or multiple static ports. A total dose of 18–75 Gy at the isocenter of tumors in 1–22 fractions was administered. The calculated biologic effective dose (BED, α/β=10) ranged from 57 Gy to 180 Gy with a median of 105. Results: All patients completed the treatment with no complaints. During the follow up of 7–127 (median=24) months, pulmonary complications greater than NCI-CTC criteria grade 2 were noted in only 6 (2.4%) patients. Of 269 patients who were evaluated with CT, we observed CR and PR in 71 (26.4%) and 159 (59.1%) patients, respectively. The local progression occurred in 34 (12.5%) of total patients, and a lower local recurrence rate was observed (8.0% vs. 26.4%, P<0.05) when BED was ≥100 Gy vs. <100 Gy. The intercurrent death was observed in 43 (15.8%), mostly in inoperable patients. The 3-year overall survival rate of medically operable patients was 95.2% vs. 69.4% (P<0.05) when BED was ≥ 100 Gy vs. < 100 Gy. Conclusions: Hypofractionated high-dose STI is a feasible and beneficial method for the curative treatment of patients with stage I NSCLC. Local control and survival rates were better for BED ≥100 Gy than for BED <100 Gy for all treatment methods and schedules. Survival rate for STI in selected patients (medically operable and BED ≥100 Gy) were excellent, potentially equal to those of surgery. No significant financial relationships to disclose.
Profiling of Endogenous Peptides in Human Synovial Fluid by NanoLC−MS:  Method Validation and Peptide Identification (2007)

Synovial fluid potentially contains markers for early diagnosis and disease progression in degenerative joint diseases such as osteoarthritis. Here, a method is described for profiling endogenous peptides in human synovial fluid, using ultrafiltration, solid-phase extraction, nanoscale liquid chromatography, and high-resolution mass spectrometry. Synovial fluid is characterized by its high viscosity, caused by the presence of the lubricant hyaluronic acid. The method proved to be capable of eliminating the high concentrations of hyaluronic acid, which appeared to be necessary to obtain satisfactory analytical performance, that is, within-day relative standard deviations of 5-15%, between-day relative standard deviations of 6-16%, a linear response of R2=0.994, a limit of detection in the femtomole range, and reproducible recoveries of 14-67%. With the developed method, in a synovial fluid sample from an osteoarthritis patient and a healthy control, in total, 501 peptides originating from 40 proteins were identified. Peptide cleavage products from six proteins that have been associated with osteoarthritis in earlier studies (collagen II, proteoglcycan 4, serum amyloid A, tubulin, vimentin, and Matrix Gla) could also be identified with our profiling method. The robustness of the method indicates that it can be applied in systems biology approaches for further studies on degenerative joint disease, eventually leading to a better understanding of the disease and its therapy, as well as the development of novel biomarkers to monitor these processes.
A set of BAC clones spanning the human genome (2004)

Using the human bacterial artificial chromosome (BAC) fingerprint-based physical map, genome sequence assembly and BAC end sequences, we have generated a fingerprint-validated set of 32 855 BAC clones spanning the human genome. The clone set provides coverage for at least 98% of the human fingerprint map, 99% of the current assembled sequence and has an effective resolving power of 79 kb. We have made the clone set publicly available, anticipating that it will generally facilitate FISH or array-CGH-based identification and characterization of chromosomal alterations relevant to disease.
Uncovering the Proteome Response of the Master Circadian Clock to Light Using an AutoProteome System (2011)

In mammals, the suprachiasmatic nucleus (SCN) is the central circadian pacemaker that governs rhythmic fluctuations in behavior and physiology in a 24-hr cycle and synchronizes them to the external environment by daily resetting in response to light. The bilateral SCN is comprised of a mere ~20,000 neurons serving as cellular oscillators, a fact that has, until now, hindered the systematic study of the SCN on a global proteome level. Here we developed a fully automated and integrated proteomics platform, termed AutoProteome system, for an in-depth analysis of the light-responsive proteome of the murine SCN. All requisite steps for a large-scale proteomic study, including preconcentration, buffer exchanging, reduction, alkylation, digestion and online two-dimensional liquid chromatography-tandem MS analysis, are performed automatically on a standard liquid chromatography-MS system. As low as 2 ng of model protein bovine serum albumin and up to 20 μg and 200 μg of SCN proteins can be readily processed and analyzed by this system. From the SCN tissue of a single mouse, we were able to confidently identify 2131 proteins, of which 387 were light-regulated based on a spectral counts quantification approach. Bioinformatics analysis of the light-inducible proteins reveals their diverse distribution in different canonical pathways and their heavy connection in 19 protein interaction networks. The AutoProteome system identified vasopressin-neurophysin 2-copeptin and casein kinase 1 delta, both of which had been previously implicated in clock timing processes, as light-inducible proteins in the SCN. Ras-specific guanine nucleotide-releasing factor 1, ubiquitin protein ligase E3A, and X-linked ubiquitin specific protease 9, none of which had previously been implicated in SCN clock timing processes, were also identified in this study as light-inducible proteins. The AutoProteome system opens a new avenue to systematically explore the proteome-wide events that occur in the SCN, either in response to light or other stimuli, or as a consequence of its intrinsic pacemaker capacity.
A new Technique for Thoracic Aortography Using the Right Supraclavicular Approach (1955)

Recent advances in vascular surgery have made many previously hopeless lesions of the thoracic aorta amenable to surgical correction. A major need exists, however, for improvement in the radiologic visualization of suspected lesions of the thoracic aorta. The purpose of this paper is to present a new method for thoracic aortography, utilizing the right supraclavicular approach. Although a number of techniques have been employed in performing thoracic aortography, none seems to be entirely satisfactory. Retrograde arterial catheterization and injection of a radiopaque dye via the carotid artery,<sup>1</sup>the radial artery,<sup>2</sup>or the femoral artery<sup>3</sup>often provide adequate visualization of the thoracic aorta but require operative arteriotomy and occasionally ligation of the vessel. Percutaneous parasternal aortic punctures are technically difficult and involve the risk of coronary perfusion.* Recently Wickbom<sup>6</sup>reported a simple direct method of percutaneous aortic injection via a cervical approach, with the needle paralleling the
QFT-Based Robust Simmering Control for Domestic Induction Cookers Using an Infrared Sensor (2010)

This paper presents a robust simmering control for induction hobs. This kind of process is almost impossible to carry out in a domestic cooker where the pot temperature is unknown. We exploit an analytical model of the cooking process to design a QFT-based controller. The resultant controller satisfies all user requirements such as a quick heating up, an accurate temperature control and a fast disturbance rejection. Additionally, the proposed temperature control can also minimize the energy consumption and, as a consequence, it can increase the efficiency of the cooking process. Finally, the effectiveness of our proposal has been verified by means of verification test in real induction hobs.
Verification of a Relaxin‐3 Knockout/<i>LacZ</i> Reporter Mouse as a Model of Relaxin‐3 Deficiency (2009)

Research on the neuropeptide relaxin-3 has predominately been conducted in rats. Anatomical studies have yielded important information on the distribution of relaxin-3 and its cognate receptor (RXFP3) within the brain, while functional studies have implicated relaxin-3 as a modulator of feeding and stress responses. Therefore, the relaxin-3/RXFP3 system represents a potential target for novel drugs to treat human disorders such as obesity, anxiety, and depression, but more research into this interesting neuropeptide in different experimental species is still required. Before conducting detailed neurochemical and behavioral examinations of a recently generated relaxin-3 knockout mouse strain, the present study determined whether this mouse was a viable model of relaxin-3 deficiency.
In situ Surface Infrared Study of DNA Hybridization on Au Island Films Evaporated on Silicon Surfaces (2009)

Here we propose a label-free detection of DNA hybridization on Au nanoisland films deposited on Si surfaces by infrared absorption spectroscopy in the geometry of multiple internal reflection (MIR-IRAS). Au nanoisland films were prepared on Si surfaces by evaporation. DNA immobilization via Au-thiol chemistry and subsequent DNA hybridization was monitored with MIR-IRAS. Interaction with complementary DNA produced an IRAS peak at ∼1686 cm-1 where the C=O stretching vibration modes of nucleobases appear. On the other hand, addition of non-complementary DNA induced no significant spectral changes in the same region. Sensitive detection of 40 nM DNA was achieved owing to the MIR geometry combined with Au nanoisland films deposited on Si which provides low-background absorption around the C=O stretching vibration region. Comparison between experimental results and theoretical prediction, obtained using the ab initio calculation, was also examined.
Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer (2013)

Fifteen dysfunctional miRNAs were engaged in metastasis-associated pathways through comodulating 7 target genes, which were identified by using a multi-step approach. The roles of these candidate genes are worth further exploration in the progression of colon cancer, and could potentially be targets in future therapy.
Laser-sharing in PON (2016)

We demonstrate the possibility of laser sharing, using a multiple-output EDFA, to be adopted by central offices serving multiple PONs, showing compatibility with NG-PON2 standard.
A Synergetic Approach to Throughput Computing on x86-Based Multicore Desktops (2010)

To exploit the full performance potential of multicore desktops, the authors propose an approach that combines cache optimization, parallelization, simdization, and autotuning in a single framework.
MELPROG code development and methods. [PWR; BWR] (1983)

The MELPROG code is being developed to follow an LWR accident from loss of rod geometry through vessel breach, including description of structure failure, debris bed formation, fission product behavior and melt-water-interactions. This paper describes the design of MELPROG and its current state of development.
ChemInform Abstract: Conformational Properties of Asymmetrically Substituted Mono‐, Di‐ and Trisulfides: Solid and Liquid Phase Raman Spectra (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wet process copying machines: A source of volatile organic compound emissions in buildings (1988)

Abstract The total volatile organic compounds and profiles of volatile organic compounds of indoor air in several office buildings with libraries were studied, mainly using sorption tubes and GC-MS. Exhaust vapors from wet-process-type copying machines proved to be a major source of the volatile organic components of the indoor air.
<sup>1</sup>H and <sup>13</sup>C spectral assignment of symmetrical bis[(4‐aminosubstituted)quinolinium] derivatives (2005)

1H and 13C NMR spectroscopic data of both the quinolinium ring and the spacers for 32 symmetrical bisquinolinium compounds were assigned by a combination of one- and two-dimensional experiments (DEPT, HMBC, HMQC). The compounds have electron-releasing groups at position 4 of the quinolinium ring, with several arylalkyl linkers such as the 3,3'-, 4,4'-bis(methylene)biphenyl and 4,4'-bis(methylene)bibenzyl moieties.
Ermüdung von Stahl × 20 Cr 13. Rißwachstum bei Lastwechselfrequenzen von 10<sup>−3</sup> Hz bis zu 21 KHz, Bestimmung des Grenzwertes ΔK<sub>0</sub> mit Ultraschall (1980)

Abstract Bruchmechanische Ermüdungsversuche wurden sowohl niederfrequent (bis 10 −3 Hertz) als auch hochfrequent (mit Hilfe von Ultraschall und Hochgeschwindigkeitschromatographie bis 2,1 × 10 4 Hertz) durchgeführt. Dabei zeigt sich, daß der Einfluß korrosiver Umgebungen auf die Ermüdungsrißwachstumsgeschwindigkeit zu höheren Frequenzene hin abnimmt. Ultraschallermüdung des Stahls in Wasser führt zu gleichen Rißgeschwindigkeiten wie niederfrequente Ermüdung im Vakuum. Insbesondere für den Bereich kleiner Spannungsintensitätswerte bietet der Ultraschall‐Ermüdungsversuch den Vorteil, den Schwellwert ΔK 0 der Spannungsintensität, unter dem kein Rißfortschritt festzustellen ist, in kurzer Zeit zu ermitteln.
Permission Management Method for Before and After Applications the Update in Android-based IoT Platform Environment (2018)

The Android-based IoT(Internet of Things) platform just like the existing Android provides an environment that makes it easy to utilize Google's infrastructure services including development tools and APIs through which it helps to control the sensors of IoT devices. Applications running on the Android-based IoT platform are often UI free and are used without the user's consent to registered permissions. It is difficult to respond to the misuse of permissions as well as to check them when they are registered indiscriminately while updating applications. This paper analyzes the versions of before and after an application the update running on the Android-based IoT platform and the collected permission lists. It aims to identify the same permissions before and after the update, and deleted and newly added permissions after the update were identified, and thereby respond to security threats that can arise from the permissions that is not needed for IoT devices to perform certain functions.
Probing the furanose conformation in the 2′–5′strand of isoDNA : RNA duplexes by freezing the nucleoside conformations (2011)

Sugar conformations in the isoDNA strand of isoDNA : RNA duplexes are preferred S-type locked/frozen in contrast to N-type locked conformations preferred in DNA : RNA duplexes.
PLTs of Blood Group A<sub>1</sub> donors express increased surface A antigen owing to apheresis and prolonged storage (2003)

Apheresis and prolonged storage of A1 group PCs independently led to overexpression of A antigen on the PLT surface. This may make such PCs more susceptible to destruction by anti-A of O or B group recipients.
Novel Dihydropyrazines and their Double ortho-Annulation to Hexaazapentacenes (2014)

The cycloacylation of oxalic amidines 7 with bis-imidoylchlorides 6 furnished the dihydropyrazine derivatives 8. Due to their vicinal amino-imino substructures, they provide good preconditions for a double intramolecular ring closure reaction. An alternative synthesis for hexaaza-pentacenes 1 was developed using potassium carbonate as the base and lead tetraacetate as the oxidizing agent.
Effects of breathing frequency on baroreflex effectiveness index and spontaneous baroreflex sensitivity derived by sequence analysis (2012)

BEI and BRSseq do not remain constant at various breathing frequencies. Nonetheless, considering the pattern of change and the frequency range of spontaneous respiration, the authors suggest that high-frequency paced breathing is not necessary when measuring the BEI and BRSseq under the conditions used in this study.
Development of a Multicenter Density Functional Tight Binding Model for Plutonium Surface Hydriding (2018)

We detail the creation of a multicenter density functional tight binding (DFTB) model for hydrogen on δ-plutonium, using a framework of new Slater-Koster interaction parameters and a repulsive energy based on the Chebyshev Interaction Model for Efficient Simulation (ChIMES), where two- and three-center atomic interactions are represented by linear combinations of Chebyshev polynomials. We find that our DFTB/ChIMES model yields a total electron density of states for bulk δ-Pu that compares well to that from Density Functional Theory, as well as to a grid of energy calculations representing approximate H<sub>2</sub> dissociation paths on the δ-Pu (100) surface. We then perform molecular dynamics simulations and minimum energy pathway calculations to determine the energetics of surface dissociation and subsurface diffusion on the (100) and (111) surfaces. Our approach allows for the efficient creation of multicenter repulsive energies with a relatively small investment in initial DFT calculations. Our efforts are particularly pertinent to studies that rely on quantum calculations for interpretation and validation, such as experimental determination of chemical reactivity both on surfaces and in condensed phases.
ChemInform Abstract: Microwave‐Assisted Synthesis and anti‐HIV Activity of New Acyclic C‐Nucleosides of 3‐(D‐ribo‐Tetritol‐1‐yl)‐5‐mercapto‐1,2,4‐triazoles. Part 1. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Light emission and the formation of radicals after grinding tea leaves. (1990)

Light emission and the ESRspectra of tea leaves treated in various ways were studied. The fresh leaf showed a delayed light emission, which decreased exponentially with half times of 15 and 54 seconds. Whenthe leaf was ground in water, the delayed light emission became small, because of destruction of the chloroplasts, and almost time-independent chemiluminescence was emitted. The chemiluminescence became very strong when the leaf was ground in an NaOHsolution. ESRspectra of the tea leaf ground in water showed a singlet absorption attributable to an organic free radical, overlapping the six-line absorption due to the Mn2+ion. The intensity of the radical became high when the leaf was treated with the NaOHsolution and increased with time. In the case of the leaf ground in an NaCl solution, the singlet signal did not appear. These results suggest that the chemiluminescence and singlet absorption of the ESR spctra are attributable to oxidation of the catechins.
Structural changes in the switching InSe compound studied by the TDPAC techniques (1983)

By using the TDPAC technique the authors were able to detect and follow the structural changes suffered by the compound InSe when submitted to a switching process. For these changes well defined electric quadrupolar frequencies, which appear and/or disappear, are associated, as clearly observed in the experimental results.
Formation of multilevel system to counteract computer attacks (2020)

The main trend relating to state structures and large corporations is to build Information Security Monitoring Centers the key elements of which being SIEM-systems and SOC-Centers. Speaking about SOC-Centers the task of human resources optimal allocation among information security incident reporting lines taking into consideration staff competency and line capacity seems to be urgent. This task is solved in the article given. In general, the formulation of the task presented means the functioning of SOC-Center as a new mathematical model making use of “input – resources – output” terms. The target function of SOC-Center is built in an assumption of stationarity and independency of service reporting lines as a sum of their target functions. The main idea of human resources management in this case is the aspiration to achieve maximum significance of SOC-Center system aim, i.e. its general target function when organizing the fight with computer attacks. The problem was solved by Lagrange multiplier method. The expressions for optimal allocation of human resources on SOC-center service lines leading to maximum processing of message flow related to computer attacks have been received. The conclusion about this model being useful for transferring from stationary flows to their dynamic changes in SOC-Center resource provision including new different critical situations in computer system has been made.
Microstructural Effects on the Thermal Conductivity of Polycrystalline Aluminum Nitride (1991)

Polycrystalline AIN bodies were made with a range of porosities from various AIN powders by sintering or hot‐pressing. Thermal conductivity data for material produced without sintering aids showed a gradual, yet definite, porosity dependence with scatter similar to other property‐porosity studies. The thermal conductivity‐porosity data for ALN with sintering aids showed the existence of two distinct regions: (1) a higher‐porosity region (greater than approximately 2%) which was similar to the data for material without sintering aids, and (2) a low‐porosity region where grain boundaries were seen to dominate thermal conductivity. Auger spectroscopy was used to investigate fracture surfaces for dense CaO‐doped materials. Thermal conductivity was observed to correlate to effective grain‐boundary thickness, which was calculated from quantitative analysis of the Auger data. A model consisting of cubic grains in a continuous grain‐boundary phase accurately describes these data.
Measurement of the production of neighbouring jets in lead–lead collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:msqrt><mml:msub><mml:mrow><mml:mi>s</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">NN</mml:mi></mml:mrow></mml:msub></mml:msqrt><mml:mo>=</mml:mo><mml:mn>2.76</mml:mn><mml:mtext> </mml:mtext><mml:mtext>TeV</mml:mtext></mml:math> with the ATLAS detector (2015)

This Letter presents measurements of correlated production of nearby jets in Pb+Pb collisions at
Phototherapeutic keratectomy for the treatment of diffuse lamellar keratitis (2002)

We report a case of laser in situ keratomileusis in which a patient with recurrent diffuse lamellar keratitis (DLK) recalcitrant to standard therapy was successfully treated with phototherapeutic keratectomy (PTK). The PTK was used to ablate both surfaces of the flap interface with the goal of removing DLK-inciting agents. The resultant sustained decrease in DLK suggests PTK is an effective therapy option.