gebhart/patrepeval huggingface dataset:
Influence of Growth Conditions on the Production of a Bacteriocin, Pediocin AcH, by <i>Pediococcus acidilactici</i> H (1991)

The influence of growth parameters on the production of pediocin AcH by Pediococcus acidilactici H was studied. This strain produced large quantities of pediocin AcH in TGE broth (Trypticase [1%], glucose [1%], yeast extract [1%], Tween 80 [0.2%], Mn [0.033 mM], Mg [0.02 mM] [pH 6.5]) within 16 to 18 h at 30 to 37 degrees C (final pH, 3.6 to 3.7). Pediocin AcH production was negligible when the pH of the medium was maintained at 5.0 or above, even in the presence of high cell mass.
Hexahalogenotitanates(III) (1966)

B. T. Russ and G. W. A. Fowles, Chem. Commun. (London), 1966, 19 DOI: 10.1039/C19660000019
Automated Generation of Oracles for Testing User-Interaction Features of Mobile Apps (2014)

As the use of mobile devices becomes increasingly ubiquitous, the need for systematically testing applications (apps) that run on these devices grows more and more. However, testing mobile apps is particularly expensive and tedious, often requiring substantial manual effort. While researchers have made much progress in automated testing of mobile apps during recent years, a key problem that remains largely untracked is the classic oracle problem, i.e., to determine the correctness of test executions. This paper presents a novel approach to automatically generate test cases, that include test oracles, for mobile apps. The foundation for our approach is a comprehensive study that we conducted of real defects in mobile apps. Our key insight, from this study, is that there is a class of features that we term user-interaction features, which is implicated in a significant fraction of bugs and for which oracles can be constructed - in an application agnostic manner -- based on our common understanding of how apps behave. We present an extensible framework that supports such domain specific, yet application agnostic, test oracles, and allows generation of test sequences that leverage these oracles. Our tool embodies our approach for generating test cases that include oracles. Experimental results using 6 Android apps show the effectiveness of our tool in finding potentially serious bugs, while generating compact test suites for user-interaction features.
Experimental study of the osteogenic capacity of periosteal allografts: A preliminary report (1994)

A total of 16 rabbits were used in this investigation. Beijing long-eared white rabbits served as donors and immunologically incompatible Chinchilla rabbits as recipients. Periosteal flaps were stripped from the femurs of 8 donor rabbits and implanted into the muscles of both thighs of 8 recipients. Revascularization of the grafts was done only on the left side. Immunosuppressants were administered orally beginning the day of surgery. The animals were observed for 1-4 months. A series of radiography, histomorphology, fluorochrome labelling, and electron microscopic examinations were performed. The results demonstrated that all of the revascularized periosteal allografts had new bone formation (8/8), while the nonrevascularized periosteal allografts had none (0/8). The difference in the rate of new bone formation between the two groups was statistically significant.
Computer Simulations for the Prediction of Microstructure/Property Variation in Aeroturbine Disks (2004)

In support of a new methodology of accelerated development and qualification of new materials, the PrecipiCalc TM software has been developed as an efficient, high-fidelity 3D multiphase precipitation simulator grounded in computational thermodynamics and multicomponent diffusional nucleation and growth models incorporating interfacial dissipations. With extensive validation under a major federally sponsored program, the software has been successfully applied to the accurate and rapid simulation of multiscale (from nm to m), multimodal microstructure development in IN100 Ni-based aeroturbine disk alloys under complex commercial heattreatment processing. Integration of PrecipiCalc with FEM heat transfer simulation and a strength model has demonstrated accurate prediction of property variation for accelerated process optimization and probabilistic modeling of design minimum properties.
A dynamic mathematical model for monoclonal antibody N‐linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus (2011)

Monoclonal antibodies (mAbs) are one of the most important products of the biopharmaceutical industry. Their therapeutic efficacy depends on the post-translational process of glycosylation, which is influenced by manufacturing process conditions. Herein, we present a dynamic mathematical model for mAb glycosylation that considers cisternal maturation by approximating the Golgi apparatus to a plug flow reactor and by including recycling of Golgi-resident proteins (glycosylation enzymes and transport proteins [TPs]). The glycosylation reaction rate expressions were derived based on the reported kinetic mechanisms for each enzyme, and transport of nucleotide sugar donors [NSDs] from the cytosol to the Golgi lumen was modeled to serve as a link between glycosylation and cellular metabolism. Optimization-based methodologies were developed for estimating unknown enzyme and TP concentration profile parameters. The resulting model is capable of reproducing glycosylation profiles of commercial mAbs. It can further reproduce the effect gene silencing of the FucT glycosylation enzyme and cytosolic NSD depletion have on the mAb oligosaccharide profile. All novel elements of our model are based on biological evidence and generate more accurate results than previous reports. We therefore believe that the improvements contribute to a more detailed representation of the N-linked glycosylation process. The overall results show the potential of our model toward evaluating cell engineering strategies that yield desired glycosylation profiles. Additionally, when coupled to cellular metabolism, this model could be used to assess the effect of process conditions on glycosylation and aid in the design, control, and optimization of biopharmaceutical manufacturing processes.
CMOS artificial neuron on the base of β-driven threshold element (2002)

The task of hardware (CMOS) implementation of artificial neuron is discussed. The main part of the device is a /spl beta/-comparator which is a voltage divider formed by p- and n-transistors. This approach is based on the possibility of ratio form representation of an arbitrary threshold function. The weight of the input is determined by the limitation of the current through the n-transistor that is equivalent to changing its actual /spl beta/. The synapse itself consists of two (input and controlling) n-transistors. The full circuit of the learnable synapse with capacitor memory contains 5 transistors and a resistor that determines the time constant of learning. The results of SPICE-simulation are given.
Validity evidence for a modified version of the Orthotics and Prosthetics Users’ Survey (2012)

This study supports the validity of a modified version of OPUS for persons using different P&O devices, but also reveals limitations to be addressed in future studies. OPUS could be useful in clinical rehabilitation and research to evaluate P&O outcomes.
Chk1 is Essential for Tumor Cell Viability Following Activation of the Replication Checkpoint (2004)

Chk1 (checkpoint kinase 1) is an evolutionarily conserved serine/threonine kinase involved in DNA damage responses. Originally identified as a kinase regulating the G2/M transition checkpoint, its role has broadened to include the S-phase checkpoint response and essential functions in early embryonic development. In this manuscript we investigated the potential of chemo-sensitization via ablation of Chk1 in cells treated with anti-metabolite cancer drugs, hydroxyurea (HU) and cytosine arabinoside (ara-C). Exposure to these replication interfering drugs in cells carrying Chk1 targeted siRNA provoked markedly increased rates of apoptosis. Although cell death was accompanied by an increase in p53 and activation of Chk2, the increased susceptibility to apoptosis was not dependent on p53 or Chk2. Additionally, we found that cells with reduced Chk1 expression displayed increased gamma-H2A.X expression, a marker for damaged DNA, and phosphorylated 32kDa subunit of replication protein A (RPA). Thus, Chk1 may play an essential role in maintaining DNA integrity during the replication block. Significantly, normal cells such as WS1 did not exhibit increased DNA damage or subsequent increases in apoptosis following replication stress, in the absence of Chk1. Thus, the essential role Chk1 plays in maintaining viability during the replication block in cancer cell lines can be exploited to sensitize cancer cells when abrogation of Chk1 is combined with DNA anti-metabolite chemotherapeutic drugs. Taken together, these data suggest that inhibition of Chk1 in combination with DNA anti-metabolite chemotherapy is a viable therapeutic strategy.
Combined use of radar and satellite information for precipitation estimation in Hungary (2002)

Radar and satellite measurements can be used for the detailed description of the properties of precipitating clouds. Radars primarily detect the existing raindrops. From the satellite radiances, however, one can derive such additional physical characteristics of the cloudiness that can provide information on the further development of the precipitation systems. In this study the authors used digitized data from a 3 and 10 cm MRL-5 radar and satellite data from the Advanced Very High Resolution Radiometer (AVHRR) on board the polar orbiting NOAA satellites. From the AVHRR radiances they derived cloud-top temperature, optical thickness and effective cloud droplet size. They also determined a cloud-class flag using thresholding and clustering classification techniques. The radar and satellite images were transformed into the same geographic projection format and displayed simultaneously for qualitative evaluation. In addition, an empirical relationship was established between coincident ground precipitation measurements, radar data and satellite cloud parameters using data from a two-year period over Hungary.
Designing Ecofriendly Bionanocomposite Assembly with Improved Antimicrobial and Potent on-site Zika Virus Vector Larvicidal Activities with its Mode of Action (2017)

Dialyzed natural polymer, fibroin, from Bombyx mori was used to synthesize biocompatible silver and gold nanoparticles in-situ in dispersion form. The films of pure fibroin (PF), fibroin-silver nanocomposite (FSNC) and fibroin-gold nanocomposite (FGNC) were fabricated by drop casting method. The characterization of the resultant dispersion and films was performed by visual color change, UV-Vis spectroscopy and atomic force microscopy. The dispersions of PF, FSNC and FGNC were tested for antibacterial activity against E. coli NCIM 2065, S. aureus NCIM 5021, K. pneumoniae NCIM 2957, P. aeruginosa ATCC 9027 and antifungal activity against A. fumigatus NCIM 902. FSNC dispersion exhibited an effective antimicrobial action against all the tested microbes as compared to FGNC dispersion. The mechanism of action for FSNC and FGNC against these microorganisms is proposed. Additionally, the larvicidal activity of the films was investigated against the larvae of Aedes aegypti. The films of FSNC exhibited 100% mortality while the films of FGNC revealed 86-98% mortality against all the larval instars and pupae of A. aegypti. The phytotoxicity study of the nanocomposite films was also carried out to confirm the reusability of water. This is first noble metal nanocomposite based report on larvicidal activity of zika virus vector.
Organophosphate-induced Delayed Neuropathy: Anomalous Data Lead to Advances in Understanding (1987)

The main purpose of this contribution is not to provide a comprehensive review of the topic. This has been done several times with emphasis on either biochemical mechanisms (Davis and Richardson, 1980; Johnson, 1975a, 1982) or pathology (Cavanagh, 1964, 1973). I wish to present a scientific detective story. The theme is the dictum cited in the title and frequently invoked by Norman Aldridge, in whose honour this volume is prepared, and the style is historical, personal and reflective.
The Adiabatic Phase and Pancharatnam's Phase for Polarized Light (1987)

Abstract In 1955 Pancharatnam showed that a cyclic change in the state of polarization of light is accompanied by a phase shift determined by the geometry of the cycle as represented on the Poincaré sphere. The phase owes its existence to the non-transitivity of Pancharatnam's connection between different states of polarization. Using the algebra of spinors and 2 × 2 Hermitian matrices, the precise relation is established between Pancharatnam's phase and the recently discovered phase change for slowly cycled quantum systems. The polarization phase is an optical analogue of the Aharonov-Bohm effect. For slow changes of polarization, the connection leading to the phase is derived from Maxwell's equations for a twisted dielectric. Pancharatnam's phase is contrasted with the phase change of circularly polarized light whose direction is cycled (e.g. when guided in a coiled optical fibre).
Thickness-mode modelling of active multi-layered piezoelectric transducers and the application to "SMART" sensor design (1994)

An advanced uni-dimensional thickness-mode transducer model has been developed, capable of simulating device configurations required to theoretically evaluate the performance of “smart” transducer systems. “Smart” transducers aim to incorporate self-sensing and self-adaption of the output response, in order to attain some predefined output characteristic. This paper presents the theoretical development of the transducer model, including verification of selected modelled responses through experimentation. Results from subsequent simulation work are discussed with a view towards highlighting the potential of self monitoring/self actuating ultrasonic devices
Hydroborations: A New Efficient Route to 1-Organo-2-indanones from 1-Alkyl(aryl)indenes (1990)

The hydroboration followed by chromic acid oxidation leads in the cases of 1-alkyl- and 1-aryl-1-indenes to the corresponding 1-organo-2-indanones in 70-80% yield.
Haptic Breakage Following Neonatal IOL Implantation in a Nonhuman Primate Model (1995)

To evaluate the long-term safety of implanting intraocular lenses (IOLs) in neonatal eyes using a nonhuman primate model, a one-piece all-polymethylmethacrylate (PMMA) IOL was implanted into the posterior chamber of 21 neonatal Rhesus monkey eyes following a lensectomy and anterior vitrectomy. These monkeys then were monitored for 26 to 40 months for complications. The eyes from seven monkeys were studied histopathologically. One or both haptics broke on 7 of the 21 (33%) IOLs in a mean of 21 months (range 6 to 31 months) after their implantation. Only one of the haptics from these seven eyes was found to be in the capsular bag when these eyes were studied histopathologically. Nine haptics had eroded into the iris leaflets, two into the ciliary body, and one into the anterior chamber. One additional haptic was in the sulcus. The haptics of one-piece all-PMMA IOLs may break if implanted in neonatal eyes. A number of factors likely contributed to haptic breakage in these eyes, including an increased number of reoperations, malpositioning of IOL haptics, rapid circumferential and axial growth, and the formation of large Soemmerring's rings.
Wireless communication protocols and resource optimization for distributed control of power networks. (2008)

Wireless communication protocols and resource optimization for distributed control of power networks.
High power control components using a new monolithic FET structure (2003)

A monolithic-switch FET (MFET) control device that can be integrated with other monolithic functions or used as a discrete component in a monolithic microwave integrated circuit (MMIC) structure is presented. The MFET device is a suitable replacement for p-i-n diodes as a generic control element in applications from 10 W to several hundred W CW, and has the advantages of a conventional GaAs switch FET (SFET). The increased power handling is due to the device's ability to overcome the breakdown voltage limitation of conventional SFETs. The design, fabrication, and performance of two high-power control components using MFET devices are described as examples of the implementation of this technology: an L-band terminated single-pole single-throw (SPST) switch, and an L-band limiter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Early and intermediate age-related macular degeneration: update and clinical review (2017)

Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in developed countries. With the aging of population, AMD will become globally an increasingly important and prevalent disease worldwide. It is a complex disease whose etiology is associated with both genetic and environmental risk factors. An extensive decline in the quality of life and progressive need of daily living assistance resulting from AMD among those most severely affected highlights the essential role of preventive strategies, particularly advising patients to quit smoking. In addition, maintaining a healthy diet, controlling other risk factors (such as hypertension, obesity, and atherosclerosis), and the use of nutritional supplements (antioxidants) are recommendable. Genetic testing may be especially important in patients with a family history of AMD. Recently, unifying criteria for the clinical classification of AMD, defining no apparent aging changes; normal aging changes; and early, intermediate, and late AMD stages, are of value in predicting AMD risk of progression and in establishing recommendations for the diagnosis, therapeutic approach, and follow-up of patients. The present review is focused on early and intermediate AMD and presents a description of the clinical characteristics and ophthalmological findings for these stages, together with algorithms for the diagnosis and management of patients, which are easily applicable in daily clinical practice.
Comparisons of the anti-proliferative effects of butyrate and aspirin on human colonic mucosa in Vitro (2000)

The short-chain fatty acid butyrate is regarded as a regulative agent in haemostasis of mucosal cell turnover. Inhibition of prostaglandin E2 synthesis is particularly involved in this regulation process. In the present study, proliferation was stimulated in colonic biopsies of 12 healthy subjects (age 51.3 years, range 25-81) by incubation with deoxycholic acid (5 micromol/l DCA). The anti-proliferative and cyclo-oxygenase-inhibiting properties of butyrate (10 mmol/l BUT) and of aspirin (555 micromol/l ASA) were investigated. Colonic cell proliferation was determined by bromodeoxyuridine immunohistochemistry. PGE2 release into the incubation medium was measured by radioimmunoassay. Incubation with DCA/ASA, DCA/BUT and DCA/ASA/BUT revealed a significant reduction in crypt cell proliferation as measured by the labelling index of the whole crypt in comparison to incubation with DCA alone (DCA/ASA: 0.14, P < 0.01; DCA/BUT: 0.15, P < 0.05; DCA/ASA/BUT: 0.15, P < 0.05, versus DCA: 0.18). The labelling index for the upper 40% of the crypt was only lower after incubation with DCA/ASA (0.023) compared to DCA (0.028) (P < 0.05). PGE2 release from biopsy specimens was only significantly decreased in the incubation media where ASA was added (DCA/ASA: 29.0 pg/mg mucosa/h, P < 0.005; DCA/ASA/BUT: 31.4 pg/mg mucosa/h, P < 0.01 versus DCA: 56.9 pg/mg mucosa/h). Butyrate and aspirin showed no synergistic effects. The results indicate a normalization of DCA-induced hyperproliferation of colonic mucosa by butyrate, and, even more efficiently, by aspirin. The data support the hypothesis that butyrate and aspirin can act as chemopreventive agents in colon carcinogenesis.
Fundamentals of electronic circuit design (2002)

Introduction to Electronics.Applications of Electronic Circuits.Amplifier Models and Frequency Response.Modeling and the Operational Amplifier.The Semiconductor Diode and Nonlinear Modeling.The MOSFET.The BJT.Integrated Circuit Design.Integrated Circuit Design with the MOSFET.Integrated Circuit Design with the BJT.The Differential Stage and the Op Amp.Feedback Amplifiers.Large Signal Circuits.Basic CMOS Logic Circuits.Appendix A: Basic Equations in Amplifier Design.Appendix B: Answers to Selected Problems.Index.
Synthesis of CF<sub>3</sub>‐Containing β‐Hetaryl‐Substituted Enones. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Characterization of the hgbA locus encoding a hemoglobin receptor from Haemophilus ducreyi (1995)

Haemophilus ducreyi can bind hemoglobin and use it as a source of heme, for which it has an obligate requirement. We previously identified and purified HgbA, a hemoglobin-binding outer membrane protein from H. ducreyi. In this report, we describe the molecular cloning, expression, DNA sequence, and mutagenesis of the structural gene for HgbA, hgbA. H. ducreyi and recombinant Escherichia coli expressing hgbA bound [125I]hemoglobin, establishing HgbA as a receptor. Insertions or deletions in the cloned hgbA gene abolished expression of HgbA and hemoglobin binding in E. coli. Mutagenesis of H. ducreyi by allelic exchange of insertions into hgbA abolished its ability to bind [125I]hemoglobin or utilize hemoglobin as a source of heme. The deduced protein sequence was similar to those of the TonB-dependent family of outer membrane receptors. The most similar member was HutA (heme receptor) from Vibrio cholerae. Tbp1 and Lbp1 (transferrin and lactoferrin receptors, respectively, from pathogenic Neisseria spp.) also showed very significant homology. Thus, by characterizing the hgbA locus, this work elucidates a potentially important role of HgbA in obtaining heme and/or iron from the host.
Application of laser radiation and magnetostimulation in therapy of patients with multiple sclerosis (2016)

This study showed that synergic action of laser radiation and magneto stimulation has a beneficial effect on improving functional status, and thus improves the quality of life of patients with multiple sclerosis. The effects of all methods of rehabilitation are persisted after cessation of treatment applications, with a particular advantage of the synergistic action of laser radiation and magneto stimulation, which indicates the possibility to elicitation in these methods the phenomenon of the biological hysteresis.
Shift Scheduling in Call Centers with Multiple Skill Sets and Transportation Costs (2007)

Workforce plans in call centers, mostly working 24 hours a day and 7 days a week, have to satisfy both customer service levels and personnel constraints. Moreover, in large metropolitans such as Istanbul, call centers provide the transportation of the staff, so that shuttle costs constitute a major part of the total operational costs. We present a mathematical model which minimizes the transportation costs while satisfying service level and personnel constraints. We test our model with data from call centers.