gebhart/patrepeval huggingface dataset:
Effects of Dietary Supplemented Amino Acids on Endogenous Hypercholesterolemia in Rats (1990)

Effects of additions of amino acids to a 20% casein diet on serum cholesterol (Ch) were studied in hypothyroid and hepatoma-bearing rats with endogenous hypercholesterolemia as well as in normal rats. In normal Wistar rats, methionine (Met) was hypercholesterolemic at the "nutritional" level (0.2-0.4%), but hypocholesterolemic at the "excess" level (1.2-2.4%). In Wistar rats with hypothyroidism induced by thiouracil, the addition of excess (1.2%) Met to the 20% casein diet reduced an endogenous hypercholesterolemia due to hypothyroidism by suppressing an elevation in (VLDL + LDL)-Ch with no significant influence on HDL-Ch. In Donryu rats received a subcutaneous implantation of AH109A cells (an ascites hepatoma line), either 1.2% Met, 1.2% cystine (Cys), or 1.2% Met and 2.5% glycine (Gly) in combination improved a hepatoma-induced hypercholesterolemia and abnormal serum lipoprotein profiles by suppressing a hepatoma-induced increase in (VLDL + LDL)-Ch. From Ch turnover studies in hepatoma-bearing rats, an impaired catabolism of Ch in the liver was suggested to be one cause for the hepatoma-induced elevation in (VLDL + LDL)-Ch. One of the dietary manipulations. met and Gly in combination (Met + Gly), was found to improve the impaired Ch catabolism, this leading to a reduction of the (VLDL + LDL)-Ch level by Met + Gly in hepatoma-bearing rats.
Insulation coordination from the probabilistic point of view (1999)

The problem of the design of the insulation characteristics of an electric power system was solved, up to very recent days, and is still solved in a large majority of cases, in a deterministic way, i.e. in choosing the highest expected dielectric stress from one side and the lowest expected dielectric strength of the equipment from the other side, and by providing a suitable gap between the two, in order to cover errors, unknown factors, and aging of the equipment. In this paper, the principles of an optimal insulation design is recalled and the cost of failure risk is introduced into the economical optimum design of transmission systems. A mathematical expression is given for two simple cases of optimum design to which the insulation coordination of a transmission system can be reduced in general. The importance of knowing the breakdown probability of an insulating component, as a function of the crest value of a given overvoltage, in these optimum designs is also pointed out and the methods to calculate such probability are exposed. A description of the experimental method is also given, which can be applied to any component samples, and of the calculation methods which enable one to derive the breakdown probability of a complex component from knowledge of the breakdown probability of its elements. Also examined is how the withstand test selections modify the breakdown probability distribution of a component. Finally, it is shown how on the basis of the above mentioned methods, one can have only estimations of breakdown probability distributions and how the uncertainties of such determinations can be taken into account in intelligent designing of insulation.
NEARLY OPTIMAL CONTROL OF NONLINEAR MARKOVIAN SYSTEMS SUBJECT TO WEAK AND STRONG INTERACTIONS (2001)

This paper develops hierarchical control schemes of nonlinear dynamic systems under Markovian disturbances subject to weak and strong interactions. The state space of the underlying Markov chain is decomposed into several groups of recurrent states and a group of transient states resulting in a singularly perturbed Markov chain formulation. Instead of finding the control of the original system directly, a limit problem that is much simpler to handle is derived. Using the optimal control of the limit system, a near optimal control policy is constructed for the original system. The asymptotic optimality of the constructed control is proved.
The Geometry of Ketene (1953)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation William F. Arendale, William H. Fletcher; The Geometry of Ketene. J. Chem. Phys. 1 October 1953; 21 (10): 1898. https://doi.org/10.1063/1.1698699 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search
optimizing Potato Seed Cutting (1989)

ABSTRACT THIS paper presents an optimization of commercial potato seed cutting operations. A computer program to simulate conventional rotary-blade cutting machines was developed and was used to predict their performance. The simulation outlined the relationships between cutting machine operating conditions and proportion of acceptable size seed pieces. The simulation was used to define the optimum cut widths and roller spacing of seed cutting machines and the range of seed tuber size to maximize the percentages of acceptable seed pieces. Experimental data from a conventional cutting machine confirmed the simulation results. The simulation results showed that more than 90% acceptable size seed pieces could be obtained using conventional rotary blade seed cutting machines if the cut width and roller spacing were optimized. The results also indicated that tubers over 280 g were not suited for seed tubers.
Direct current electrical fields induce apoptosis in oral mucosa cancer cells by NADPH oxidase‐derived reactive oxygen species (2007)

The presence of more than one dental alloy in the oral cavity often causes pathological galvanic currents and voltage resulting in superficial erosions of the oral mucosa and eventually in the emergence of oral cancer. In the present study the mechanisms of apoptosis of oral mucosa cancer cells in response to electromagnetic fields was investigated. Direct current (DC) electrical fields with field strengths between 2 and 16 V/m, applied for 24 h to UM-SCC-14-C oral mucosa cancer cells, dose-dependently resulted in decreased cell proliferation as evaluated by Ki-67 immunohistochemistry and upregulation of the cyclin-dependent kinase (CDK) inhibitors p21(cip1/waf1) and p27(kip1), which are associated with cell cycle arrest. Electrical field treatment (4 V/m, 24 h) increased apoptosis as evaluated by immunohistochemical analysis of cleaved caspase-3 and poly-(ADP-ribose)-polymerase-1 (PARP-1). Furthermore, robust reactive oxygen species (ROS) generation, increased expression of NADPH oxidase subunits as well as Hsp70 was observed. Electrical field treatment (4 V/m, 24 h) resulted in increased expression of Cu/Zn superoxide dismutase and decreased intracellular concentration of reduced glutathione (GSH), whereas the expression of catalase remained unchanged. Pre-treatment with the free radical scavenger N-acetyl cysteine (NAC) and the superoxide dismutase mimetic EUK-8 abolished caspase-3 and PARP-1 induction, suggesting that apoptosis in oral mucosa cancer cells is initated by ROS generation in response to DC electrical field treatment.
Performance analysis of DWT based OFDM with index modulation under channel estimation error (2017)

Inspired by the high spectral efficiency improvement of the Spatial Modulation (SM), Orthogonal Frequency Division Multiplexing with Index Modulation (OFDM-IM) was recently proposed and expected to be one of the key technologies of 5G systems. This novel transmission technique incorporates the index of active subcarriers to convey additional information. Similar to conventional OFDM, channel estimation error is considered as a dominant performance degrading cause of OFDM-IM system. This paper deals with robust OFDM-IM system implementation under practical conditions. For this purpose, Discrete Wavelet Transform (DWT) based OFDM-IM is announced to improve the performance of the conventional OFDM-IM affected by non ideal channel estimation. To this purpose, DWT based OFDM-IM performance in terms of Bit Error Rate (BER) is compared to the original OFDM-IM based on Fast Fourier Transform (FFT) in the presence of channel estimation error. Simulation results are provided to prove the performance enhancement of our proposed system over Rayleigh fading channel.
Murderous projections (2018)

When projections are not processed, they can become violent and extremely destructive. When we talk about mechanisms of transference and counter-transference, we can be fooled into thinking that they are just big words, for intellectuals, and have nothing to do with reality, with the impact and the force of facts. But that is not exactly true. One day I was asked to intervene in the psychiatric department of an Italian local health unit (LHU). I intervened using an Institutional Transformation methodology. Periodically over several days, I met, simultaneously or successively, all the LHU members, from the porter to the medical director, with the only exception being the small team responsible for emergency interventions. So we organized a first plenary session with all the members of the Department. On arrival, I realize that the chairs are laid out in a complete mess. Similarly the way in which individuals start speaking, one after the other, is in a disjointed or incoherent way, the discussion appears to be following anyone’s goodwill. Then a description emerges, through the participants, of a department made up of anarchical cells, impossible to regulate and with a tendency to proliferate, putting at risk the department’s very existence. It would appear that only 84the medical director is choosing to resist this “corruption” phenomenon. Now a revelation is made that he has just found out that he has cancer, and that he is being treated for it outside his territory.
Isolation and Characterization of Myostatin Complementary Deoxyribonucleic Acid Clones from Two Commercially Important Fish: Oreochromis mossambicusand Morone chrysops* (2001)

In mammals, skeletal muscle mass is negatively regulated by a muscle-derived growth/differentiating factor named myostatin (MSTN) that belongs to the transforming growth factor-beta superfamily. Although putative MSTN homologs have been identified from several vertebrates, nonmammalian orthologs remained poorly defined. Thus, we isolated and characterized MSTN complementary DNA clones from the skeletal muscle of the tilapia Oreochromis mossambicus and the white bass Morone chrysops. The nucleic and amino acid sequences from both fish species are highly homologous to the previously identified mammalian and avian orthologs, and both possess conserved cysteine residues and putative RXXR proteolytic processing sites that are common to all transforming growth factor-beta family members. Western blotting of conditioned medium from human embryonal kidney (HEK293) cells overexpressing a His-tagged tilapia MSTN indicates that the secreted fish protein is processed in a manner similar to mouse MSTN. However, in contrast to mice, MSTN expression in tilapia is not limited to skeletal muscle as it occurs in many tissues. Furthermore, the timing of MSTN expression in developing tilapia larvae coincides with myogenesis. These results suggest that the biological actions of MSTN in the tilapia and possibly in other fishes may not be limited to myocyte growth repression, but may additionally influence different cell types and organ systems.
Carcinogenic damage to deoxyribonucleic acid is induced by near-infrared laser pulses in multiphoton microscopy via combination of two- and three-photon absorption (2012)

Nonlinear optical imaging modalities (multiphoton excited fluorescence, second and third harmonic generation) applied in vivo are increasingly promising for clinical diagnostics and the monitoring of cancer and other disorders, as they can probe tissue with high diffraction-limited resolution at near-infrared (IR) wavelengths. However, high peak intensity of femtosecond laser pulses required for two-photon processes causes formation of cyclobutane-pyrimidine-dimers (CPDs) in cellular deoxyribonucleic acid (DNA) similar to damage from exposure to solar ultraviolet (UV) light. Inaccurate repair of subsequent mutations increases the risk of carcinogenesis. In this study, we investigate CPD damage that results in Chinese hamster ovary cells in vitro from imaging them with two-photon excited autofluorescence. The CPD levels are quantified by immunofluorescent staining. We further evaluate the extent of CPD damage with respect to varied wavelength, pulse width at focal plane, and pixel dwell time as compared with more pronounced damage from UV sources. While CPD damage has been expected to result from three-photon absorption, our results reveal that CPDs are induced by competing twoand three-photon absorption processes, where the former accesses UVA absorption band. This finding is independently confirmed by nonlinear dependencies of damage on laser power, wavelength, and pulse width.
Macrophage free cholesterol content regulates apolipoprotein E synthesis. (1987)

The relationship between macrophage cholesterol content and apolipoprotein E (apoE) synthesis was studied in mouse peritoneal macrophages. Incubations in acetylated low density lipoprotein led to a concentration-dependent increase in macrophage free and esterified cholesterol content and apoE synthesis. Enhanced apoE production reflected increased apoE mRNA abundance in cholesterol-enriched cells. Including an inhibitor of acyl-CoA:cholesterol acyltransferase in incubations with acetylated low density lipoprotein did not diminish the apoE response, suggesting that increased macrophage free cholesterol content was responsible for enhancing apoE production. Incubations in 25-OH cholesterol also produced a dose-dependent stimulation of macrophage apoE synthesis. Removing free cholesterol from cells using high density lipoprotein returned apoE synthetic rates toward base line. Macrophage lysate apoE and medium apoE levels changed in parallel during cholesterol loading and efflux indicating that regulation of apoE by free cholesterol was not primarily at the level of secretion. It is concluded that (a) cholesterol enrichment of macrophages increases apoE mRNA abundance and stimulates apoE synthesis and secretion; (b) neither cholesterol esterification nor cholesteryl ester accumulation are required for increased apoE production.
Monoliths in Bioprocessing (2012)

This chapter contains sections titled: Introduction Properties of Chromatographic Monoliths Monolithic Analytical Columns for Process Analytical Technology Applications Monoliths for Preparative Chromatography Enzyme Reactors Conclusions References
The limitation of ultrasonic flaw sizing by a model-based approach (1992)

A simple model has been developed that accounts for the excitation signal to the transducer, the transducer characteristics, and the diffraction of the sound for the purpose of flaw sizing. The goal has been to seek the ramp response that is the second integral of the impulse response. The ramp response yields volume and cross-sectional area information about the flaw. This research has demonstrated that all of the above mechanisms are high-pass frequency filters whereas the frequency content needed for the ramp response is low, namely ka&lt;2. Unfortunately the physical mechanisms reduce the low-frequency content well below the noise levels and it is impossible to extract the information required even though the transducer is driven with a signal that contains a large amount of low-frequency content.
Microscopic studies on aminolevulinic-acid-incubated tumor cells and tumor spheroids (1994)

Various microscopy techniques were employed to measure subcellular porphyrin distribution in ALA-incubated tumor cells and tumor spheroids. In addition, photodynamically-induced intracellular changes in morphology and fluorescence were detected. Studies were carried out by confocal laser scanning microscopy, polarization microscopy, video-intensified microscopy, video-enhanced contrast microscopy, time-resolved and time-gated spectroscopy, and spectrally-resolved fluorescence imaging using a tunable liquid crystal filter. It was found that ALA-incubation results in the biosynthesis of protoporphyrin IX (PP IX) in the mitochondria. Long ALA incubation times (>6 h) results in PP IX release to the cytoplasm. PP IX fluorescence has a maximum at 635 nm and a fluorescence decay time of 16 ns. No evidence for the existence of short-lived dimers, aggregates of PP IX, or other porphyrins was found. Cell irradiation resulted in cytotoxic reactions which, in turn, led to mitochondrial swelling followed by destruction of the cell membrane. In addition, PP IX photodestruction and the formation of short-lived chlorin-type photoproducts were observed.
Prostanoid receptors in human uterine myocytes: the effect of reproductive state and stretch (2005)

In the human, prostanoids are known to be important mediators of uterine relaxation and contraction during pregnancy and parturition. We have previously shown that stretch of uterine smooth muscle cells increased prostaglandin H synthase 2 (PGHS-2) mRNA expression, PGHS-2 peptide synthesis and activity, however, the net effect on uterine contractility of this increase in prostaglandin synthesis would be determined by the expression of the different prostanoid receptors. Therefore, the aims of this study were to establish the expression of prostanoid receptor mRNA in uterine myocytes obtained from women in different reproductive states and to test the hypothesis that stretch of uterine myocytes alters prostanoid receptor mRNA expression to promote uterine contractility. Myocytes were isolated from women undergoing hysterectomy (NP) and pregnant women undergoing LSCS either before (NL) or after the onset of labour (L) and were subjected to 11% stretch for 1 h (n = 6 in all cases). Copy numbers of the individual receptors varied widely with reproductive state but followed the pattern: FP > IP = DP = EP-4 > TP = EP-3 = EP-2 > EP-1. FP mRNA expression was significantly lower in the NL group compared to the NP group and EP-3, EP-4 and TP mRNA expression was significantly lower in both NL and L groups compared to NP group levels. The level of mRNA expression of EP-1, EP-2, DP and IP did not differ between NP, NL and L groups. Stretch of cells derived from the NP group resulted in a significant decrease in EP-4 mRNA expression alone and of the NL group a significant decrease in EP-2 mRNA expression alone. Stretch had no effect on cells derived from the L group. These data show that pregnancy is associated with a significant reduction in 3 of 4 pro-contraction associated prostanoid receptor mRNA expression and 1 of 4 pro-relaxant. Stretch elicited no consistent change in prostanoid receptor mRNA expression.
The effect of different salivary calcium concentrations on the erosion protection conferred by the salivary pellicle (2017)

Abstract Different proportions of mineral ions in saliva can influence the protective effect the salivary pellicle provides against dental erosion. To investigate the effect of different calcium concentrations in human saliva on the protection against enamel erosion, enamel specimens were divided into 8 treatment groups: humid chamber (Ctrl); whole mouth stimulated human saliva (HS); artificial saliva containing different calcium concentrations (AS low , AS medium , AS high ); and dialysed human saliva containing different calcium concentrations (DS low , DS medium , DS high ). The specimens underwent 4 cycles of incubation in the treatment group followed by an erosive challenge. Surface hardness and calcium release were measured during the cycling process. All DS groups exhibited significantly higher enamel surface softening than HS and the corresponding AS groups. Among the DS groups, the surface softening was significantly higher in DS low than in DS high . No significant differences were found within the AS or DS groups regarding calcium release. The results of this study indicated that erosion protection conferred by saliva depends on an interplay between salivary proteins and ions. While both proteins and ions have a positive effect on their own, the combination of the two can lead to different degrees of protection or even negative effects, depending on the relative concentrations.
Drain contact boundary specification in windowed Monte-Carlo device analysis (1988)

To accurately analyze hot-carrier transport in a reasonable CPU time, a device analysis algorithm has been developed to couple the drift-diffusion model and the Monte Carlo (MC) method. In this algorithm, since the MC method is applied only in a portion of the device which is called the window, where to place the window boundaries in the device is extremely important for accurate simulations. To overcome the difficulties of window drain contact specification, the criterion of equivalent current collection has been defined, and an expression for calculating the drain contact length has been derived. The approach has been verified by good agreement between the simulation results and the experimental measurements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Office in its Environment (1985)

All those about to begin study for examinations in Office Practice, Secretarial Duties, Clerical Duties or other related subjects should be familiar with the terms used to describe an office and its functions. The function of 'offices', whatever they may be, should be seen as part of the whole commercial process. 'That group of activities concerned with getting goods from those who first produce them to those who finally consume (use) them.' A chain of production often suggests points at which the office function may take place (see Figure 1.1).
Disquisiciones en torno al aborto (2011)

Sin duda, este tema se puede enfocar desde el punto de vista biológico, filosófico, social, y legal sin que ninguno prevalezca sobre el otro. Pero enfocar el tema no es lo mismo que vivirlo. Al enfocarlo lo analizamos desde la distancia mientras que al vivirlo ponemos en juego el bienestar personal y nuestras tensiones sociales.
Débruitage, alignement et reconstruction 3D automatisés en tomographie électronique – Applications en Sciences des Matériaux (2016)

Electron tomography is a 3D non-destructive nano-characterization technique. It is an essential technique in the field of nanotechnologies to characterize complex structures particularly when 2D projections using a transmission electron microscope (TEM) are inappropriate for understanding the 3D sample morphology. During this thesis each one of the necessary steps of electron tomography have been studied: sample preparation, TEM acquisition, projection alignment and inversion algorithms. The main contributions of this thesis are (i) the development of a new complete procedure of automatic denoising, alignment and reconstruction for a routine use of electron tomography (ii) the extension of the technique to thicker specimen and specimen being damaged during the acquisition and finally (iii) the improvement of chemical tomography reconstructions using as much information as possible. All those contributions are possible taking advantage of the use of needle-shaped samples to acquire projections on an ideal tilt range of 180°. A software has been developed during this thesis to allow users to simply apply most of the contributions proposed in this work.