gebhart/patrepeval huggingface dataset:
Generation of a GDE heterozygous mutation human embryonic stem cell line WAe001-A-14 by CRISPR/Cas9 editing (2017)

Glycogen debranching enzyme (GDE) plays a critical role in glycogenolysis. Mutations in the GDE gene are associated with a metabolic disease known as glycogen storage disease type III (GSDIII). We generated a mutant GDE human embryonic stem cell line, WAe001-A-14, using the CRISPR/Cas9 editing system. This cell line contains a 24-nucleotide deletion within exon-13 of GDE, resulting in 8 amino acids (TRLGISSL) missing of the GDE protein from amino acid position 567 to 575. The WAe001-A-14 cell line maintains typical stem cell morphology, pluripotency and in vitro differentiation potential, and a normal karyotype.
Lower Bounds on Maximum Signal-to-Noise Ratios for Digital Communication Over the Gaussian Channel (1964)

This paper considers the performance of a class of digital communication systems wherein a uniformly distributed stationary process from an analog source is sampled and quantized and transmitted by means of a generalized form of pulse-code modulation (PCM). It is shown that output signal-to-noise ratios may be obtained which increase exponentially as a function of the channel signal-to-noise ratio in the bandwidth of the source. Lower bounds on the maximum exponent for an optimized system are obtained for conventional PCM, for coded PCM with no coding delay and for coded PCM with arbitrarily large delay. Improved performance is obtained at the cost of considerable expansion of the modulated bandwidth over the source bandwidth. Expressions for the bandwidth expansion for these systems are also obtained. Mention is made of the similarity of these exact results for digital systems to recent approximate results for analog modulation systems.
The II Method for Estimating Multivariate Functions From Noisy Data (1991)

The Π method for estimating an underlying smooth function of M variables, (x l , …, xm ), using noisy data is based on approximating it by a sum of products of the form Π m φ m (x m ). The problem is then reduced to estimating the univariate functions in the products. A convergent algorithm is described. The method keeps tight control on the degrees of freedom used in the fit. Many examples are given. The quality of fit given by the Π method is excellent. Usually, only a few products are enough to fit even fairly complicated functions. The coding into products of univariate functions allows a relatively understandable interpretation of the multivariate fit.
A 28-GHz SiGe Up-Conversion Mixer Using a Series-Connected Triplet for Higher Dynamic Range and Improved IF Port Return Loss (2006)

This work presents a fully integrated SiGe microwave up-conversion mixer, utilizing a new circuit topology consisting of a common-base, series-connected triplet at the IF port to achieve a significant improvement in dynamic range. This circuit functions with an IF signal of 1.25 GHz, and has an input 1-dB compression point (IP/sub 1dB/) of -6.8 dBm, for an RF output at 28 GHz. The circuit operates over a frequency range from 19 to 31 GHz, with a maximum conversion gain of 1 dB. The mixer can operate over an IF range from 1 to 10 GHz, while maintaining an IF port return loss greater than 10 dB.
Interface defects in SiC power MOSFETs - An electrically detected magnetic resonance study based on spin dependent recombination (2014)

This study presents electrically detected magnetic resonance (EDMR) measurements on a silicon carbide (SiC) MOSFET having the structure of a double-diffused silicon MOSFET (DMOS). The resonance pattern of a SiC DMOS was measured by monitoring the change of the recombination current between the source/body and the drain. The amplitude of the response has a maximum when the device is biased in depletion due to the equal concentrations of electrons and holes at the interface resulting in the most efficient recombination. The measured anisotropic g-tensor has axial symmetry with g∥ = 2.0051(4) (B ‖ c-axis), and g⊥ = 2.0029(4) (B⊥ c-axis) and the pattern shows several hyperfine (HF) peaks. We tentatively identify the observed defect as a silicon vacancy located directly at the interface.
Experimental investigation of the athermal orientation in Yb:KGW (2006)

A comparative, experimental study between b-cut Yb:KGW and Yb:KGW cut along a proposed athermal direction is presented. The athermal direction gives a significantly weaker thermal lens, lower astigmatism and higher beam quality under lasing conditions.
Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry (2012)

Multiple myeloma remains largely incurable. However, a few patients experience more than 10 years of relapse-free survival and can be considered as operationally cured. Interestingly, long-term disease control in multiple myeloma is not restricted to patients with a complete response, since some patients revert to having a profile of monoclonal gammopathy of undetermined significance. We compared the distribution of multiple compartments of lymphocytes and dendritic cells in the bone marrow and peripheral blood of multiple myeloma patients with long-term disease control (n=28), patients with newly diagnosed monoclonal gammopathy of undetermined significance (n=23), patients with symptomatic multiple myeloma (n=23), and age-matched healthy adults (n=10). Similarly to the patients with monoclonal gammopathy of undetermined significance and symptomatic multiple myeloma, patients with long-term disease control showed an expansion of cytotoxic CD8(+) T cells and natural killer cells. However, the numbers of bone marrow T-regulatory cells were lower in patients with long-term disease control than in those with symptomatic multiple myeloma. It is noteworthy that B cells were depleted in patients with monoclonal gammopathy of undetermined significance and in those with symptomatic multiple myeloma, but recovered in both the bone marrow and peripheral blood of patients with long-term disease control, due to an increase in normal bone marrow B-cell precursors and plasma cells, as well as pre-germinal center peripheral blood B cells. The number of bone marrow dendritic cells and tissue macrophages differed significantly between patients with long-term disease control and those with symptomatic multiple myeloma, with a trend to cell count recovering in the former group of patients towards levels similar to those found in healthy adults. In summary, our results indicate that multiple myeloma patients with long-term disease control have a constellation of unique immune changes favoring both immune cytotoxicity and recovery of B-cell production and homing, suggesting improved immune surveillance.
Effects of SC-52458, an Angiotensin AT1 Receptor Antagonist, in the Dog (1997)

We have previously reported on the basic pharmacologic properties of SC-52458 (5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl) methyl]-2-[2-(1H-tetrazol-5-ylphenyl)]pyridine), a novel angiotensin (AII) receptor antagonist that binds potently to AT1 receptors in rat adrenal cortex and blocks AII-mediated contraction in isolated rabbit aorta. In the present study, the ability of SC-52458 to block AII pressor responses in conscious dogs was measured. In addition, we determined whether SC-52458 lowered mean arterial pressure in dogs with 2 kidney/1 clip renal hypertension when given daily for 4 days. In conscious, normotensive dogs, SC-52458 at 30 mg/kg orally, blocked the pressor response to AII (50 ng/kg, intravenously) with maximal inhibition (91%) observed 2 h after dosing. Plasma concentrations of SC-52458 measured by HPLC also were highest at the 2-h time point. After 24 h, the AII pressor response remained inhibited (by 35%) and SC-52458 was still measurable in plasma from treated dogs. In dogs made hypertensive by constriction of the left renal artery, SC-52458 lowered mean arterial pressure compared to vehicle treatment although heart rate was not different in the two groups. The maximal blood pressure lowering achieved with SC-52458 was similar to the maximal effect observed with the angiotensin converting enzyme inhibitor lisinopril. We conclude that SC-52458 blocks AII mediated pressor responses in normotensive, conscious dogs and SC-52458 is an efficacious antihypertensive agent in dogs with 2 kidney/1 clip renal hypertension.
Effects of denervation on laryngeal muscles: A canine model (1992)

The purpose of this study was to chronologically evaluate the changes in functional and histomorphometry of denervated laryngeal muscles. In 14 adult mongrel dogs, a 2.5-cm segment of the right recurrent laryngeal nerve was excised. Videolaryngoscopy and electromyography were performed at 1, 2, 3, 4, 5, 6, and 9 months under intravenous sedation. The animals were then killed, and the laryngeal muscles were processed for histochemical reactions. The mean muscle fiber diameter, standard deviation, and muscle fiber type composition were determined. The findings indicate that, following recurrent laryngeal nerve sectioning, the canine intrinsic laryngeal muscles undergo denervation atrophy for approximately 3 months, after which reinnervation occurs. The source of reinnervation appears to be from regenerated nerve fibers of the sectioned recurrent laryngeal nerve. The nerve fibers nonselectively reinnervated the abductor and adductor muscles of the larynx.
Efficient Generation of Craig Interpolants in Satisfiability Modulo Theories (2009)

The problem of computing Craig Interpolants has recently received a lot of interest. In this paper, we address the problem of efficient generation of interpolants for some important fragments of first order logic, which are amenable for effective decision procedures, called Satisfiability Modulo Theory solvers. We make the following contributions. First, we provide interpolation procedures for several basic theories of interest: the theories of linear arithmetic over the rationals, difference logic over rationals and integers, and UTVPI over rationals and integers. Second, we define a novel approach to interpolate combinations of theories, that applies to the Delayed Theory Combination approach. Efficiency is ensured by the fact that the proposed interpolation algorithms extend state of the art algorithms for Satisfiability Modulo Theories. Our experimental evaluation shows that the MathSAT SMT solver can produce interpolants with minor overhead in search, and much more efficiently than other competitor solvers.
HIGH FREQUENCY DISCHARGE IN GAS AT LOW PRESSURES. EXPERIMENTAL STUDY OF HIGH FREQUENCY ION SOURCES (1957)

The theory of high-frequency discharge in gas at low pressures is investigated, and the distribution function of electrons present in the gas is calculated. The evolution of the electronic density at the center of the discharge tube is studied in attributing to the secondary emission from the walls of the tube an essential role in electron multiplication. The conditions of starting are obtained. In the second part a detailed description of an ion source functioning at 96.5 Mc/s is given, and measurements made on it and the search for a theoretical explanation of certain of its properties are discussed. A brief analysis of different types of high-frequency ion sources is given, along with their utilization in corpuscular microscopy and particle accelerators. (J.S.R.)
Large breast compressions: Observations and evaluation of simulations (2011)

Breasts in the prone position exhibited an anisotropic compression behavior. Transverse isotropic materials with an increased stiffness in the anterior-posterior direction improved the prediction of these deformations and produced more realistic mammogram simulations from MR images.
Rational Synthesis of Hyperbranched Poly(ester)s (2017)

Hyperbranched poly(ester)s have a variety of unique properties as a result of their abundance of end groups which make them useful in a range of applications. The synthesis of hyperbranched polymers has generally been carried out using empirically derived procedures to avoid gelation. However, such synthetic strategies lead to materials with unpredictable molecular weight and properties. It has now been demonstrated that modeling may be utilized to direct the synthesis of hyperbranched poly(ester)s from a variety of monomers to form well-defined structures and terminal-group functionality while avoiding gelation. In particular, Macosko–Miller modeling permits the synthesis of hyperbranched poly(ester)s of specific molecular weights and end-group functionality even for multifunctional monomers for which functional groups are not equally reactive.
Poly(vinylidene fluoride-hexafluopropylene)-Based Gel Electrolytes for Lithium Ion Secondary Batteries (2001)

For a thin film lithium-ion secondary battery, it is important to use a polymer or gel electrolyte with high ionic conductivity and good mechanical strength. In this work, two types of poly(vinylidene fluoride hexafluopropylene) (PVdF-HFP) were compared as preparing gel electrolyte for lithium-ion secondary battery. The PVdF-HFP copolymers polymerized by the emulsion method (PVdF-HFPe) and the suspension method (PVdF-HFPs), were applied in this study. The gel electrolyte was prepared by casting the THF solution of mixture of PVdF-HFP, ethylene carbonate (EC), propylene carbonate (PC) and LiClO4 salt. All of the gel electrolytes exhibited a typical arrhenius behavior in temperature dependence of ionic conductivity, and gave a high ionic conductivity of 1-3 mS cm−1 at ambient temperature when adding the 1.75 ml plasticizer to 1 g PVdF-HFP. Especially, the PVdF-HFPs gel showed a higher mechanical strength over 4 M Pa. With the cyclic voltammetry, the PVdF-HFPs gel electrolyte showed anodic stability up to above 4.0 V on Ni, Al, and stainless steel (SUS), and cathodic stability down to Li deposition potential on Cu, Ni and SUS. It was also suggested that the anode (MCMB) or cathode (LiCoO2) active material could work in the PVdF-HFPs gel electrolyte.
Lower Bound of Energy-Latency Tradeoff of Opportunistic Routing in Multihop Networks (2010)

Opportunistic networking aims at exploiting sporadic radio links to improve the connectivity of multihop networks and to foster data transmissions. The broadcast nature of wireless channels is an important feature that can be exploited to improve transmissions by using several potential receivers. Opportunistic relaying is thus the first brick for opportunistic networking. However, the advantage of opportunistic relaying may be degraded due to energy increase related to having multiple active receivers. This paper proposes a thorough analysis of opportunistic relaying efficiency under different realistic radio channel conditions. The study is intended to find the best tradeoff between two objectives: energy and latency minimizations, with a hard reliability constraint. We derive an optimal bound, namely, the Pareto front of the related optimization problem, which offers a good insight into the benefits of opportunistic routings compared with classical multihop routing schemes. Meanwhile, the lower bound provides a framework to optimize the parameters at the physical layer, MAC layer, and routing layer from the viewpoint of cross layer during the design or planning phase of a network.
Optics of carriers trapped in lateral superlattices (1998)

The Brazilian Portuguese version under study presented a different behavior from the original measurement tool, but proved to be a reliable and valid instrument in assessing the Brazilian population's knowledge about HPV.
Protein Degradation with Photoactivated Enediyne‐Amino Acid Conjugates. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Dietary fat plays a major role in obesity: no (2002)

The percentage of dietary energy from fat has been suggested to be an important determinant of body fat, and this presumed effect has been invoked to justify the general promotion of low-fat diets. Dietary fat and the prevalence of obesity are lower in poor countries than in affluent countries. However, these contrasts are seriously confounded by differences in physical activity and food availability; within areas of similar economic development, per capita intake of fat and the prevalence of obesity have not been positively correlated. Randomized trials are the preferable method for evaluating the effect of dietary fat on adiposity because they avoid problems of confounding that are difficult to control in other studies. In short-term trials, a small reduction in body weight is typically seen in individuals randomized to diets with a lower percentage of calories from fat. In a meta-analysis of these trials, it was estimated that a decrease in 10% of energy from fat would reduce weight by 16 g d-1, which would correspond to a 9-kg weight loss by 18 months. However, compensatory mechanisms appear to operate because in trials lasting one year or longer, fat consumption within the range of 18-40% of energy has consistently had little, if any, effect on body fatness. Moreover, within the United States (US), a substantial decline in the percentage of energy from fat during the last two decades has corresponded with a massive increase in obesity, and similar trends are occurring in other affluent countries. Diets high in fat do not account for the high prevalence of excess body fat in Western countries; reductions in the percentage of energy from fat will have no important benefits and could further exacerbate this problem. The emphasis on total fat reduction has been a serious distraction in efforts to control obesity and improve health in general.
Impact of the intensity of the pretransplantation conditioning regimen in patients with prior invasive aspergillosis undergoing allogeneic hematopoietic stem cell transplantation: a retrospective survey of the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation (2006)

In this retrospective study, we analyzed the outcomes of 129 patients who underwent an allogeneic hematopoietic stem cell transplantation (allo-HSCT) and had a history of probable or proven invasive aspergillosis (IA), of whom 57 (44%) received a reduced-intensity conditioning (RIC). Overall, 27 patients with IA progressed after the allo-HSCT (cumulative incidence [CumInc] at 2 years, 22%). The variables that increased the 2-year CumInc of IA progression were (1) longer duration of neutropenia after transplantation; (2) advanced status of the underlying disease; and (3) less than 6 weeks from start of systemic anti-Aspergillus therapy and the allo-HSCT. In addition, (4) conventional myeloablative conditioning increased the risk of progression early after transplantation (before day 30) only, while 3 variables increased the risk beyond day 30 were (5) cytomegalovirus disease; (6) bone marrow or cord blood as source of stem cells; and (7) grades II to IV acute graft-versus-host disease (GVHD). A risk model for progression was generated, defined as low (0-1 risk factors, 6% incidence), intermediate (2-3 risk factors, 27% incidence), or high risk (> 3 risk factors, 72% incidence [P < .001]). These findings may help in the interpretation and design of future studies on secondary prophylaxis of IA after an allo-HSCT. (Blood.
Novel developments in optical image analysis for iron ore, sinter and coke characterisation (2015)

A textural approach to the geometallurgical characterisation of iron ores helps better predict ore behaviour during downstream processing. Therefore, a robust, automated, objective method for the textural characterisation of iron ores is relevant to both research and industry needs. Utilisation of an optical image analysis (OIA) technique allows reliable and consistent identification of different iron oxide and oxy-hydroxide minerals, e.g. haematite, kenomagnetite, hydrohematite, both vitreous and ochreous goethite. CSIRO Mineral4/Recognition4 OIA system automatically identifies particle sections with different textures and assigns these sections to defined textural groups. Furthermore, novel developments in the system have enabled the automatic identification of different textural forms and morphologies of the same mineral, e.g. martite and microplaty haematite in iron ore; primary and secondary haematite or different types of Silico-Ferrite of Calcium and Aluminium (SFCA) in sinter as well as segmentation of different phases with the same reflectivity like Inert Maceral Derived Components (IMDC) from Reactive Maceral Derived Components (RMDC) in coke.The high resolution and imaging speed of the OIA system makes it possible for users to significantly reduce the cost and subjectivity of iron ore characterisation with a simultaneous increase in the accuracy of mineral identification. Extra software modules have been developed to meet research and industry demands for enhanced productivity. The addition of a ‘Multiple Block Imaging’ module enables image acquisition for sets of polished blocks at a time, rather than separate imaging of individual blocks. The ‘Multiple Set Processing’ module allows the processing up to 20 groups of sets simultaneously, where every group can contain up to 20 different sets of images that share the same analysis profile. The added modules enable analyses to be performed over many hours without the need for operator intervention, thus increasing equipment utilisation and reducing operator time.These new developments, together with the improvement of previously available features, e.g. identification of non-opaque minerals, automated textural classification, automated particle separation, automated correction of mineral maps and on-line measurement, means that OIA can provide a unique, reliable, industry and research focused tool for iron ore, sinter and coke characterisation.
Hydrocracking Science and Technology (1996)

Presents advances in the field of hydrocracking. The volume includes catalytic materials, reaction mechanisms and pathways, as well as hydrocracking processes and applications. It discusses hydrocracking processes and hydrocracking technology in catalytic dewaxing, resid upgrading, and fluid catalytic cracking feedstock improvement
Effect of Home Total Parenteral Nutrition on Body Composition in Patients with Acquired Immunodeficiency Syndrome (1990)

Malnutrition occurs commonly in patients with acquired immunodeficiency syndrome (AIDS). The efficacy of nutritional support is unknown. A prospective, longitudinal study was conducted to determine the effect of prolonged total parenteral nutrition on body composition in 12 AIDS patients. Five patients were malnourished because of problems with food intake or absorption, while seven had systemic infections, with or without a malabsorption syndrome. The AIDS patients gained body weight and body fat content in response to total parenteral nutrition, while mean body cell mass, estimated as total body potassium content, was unchanged. However, all five patients with altered intake or absorption had significant repletion of body cell mass which was significantly different from the patients with systemic infections. Calorie and nitrogen intake did not differ between the two groups. It is concluded that body mass repletion is possible in AIDS patients in whom malabsorption is the major pathogenetic factor in producing malnutrition and is less successful in patients with serious ongoing systemic diseases. Thus, the response to nutritional support is dependent on the particular clinical circumstances.