gebhart/patrepeval huggingface dataset:
Optimized Joint Unicast-Multicast Panoramic Video Streaming in Cellular Networks (2020)

In this paper we present Joint Unicast-Multicat Panoramic Streaming (JUMPS) over the cellular network. JUMPS optimizes the resource allocation for a group of eMBMS (evolved Multicast Broadcast Multimedia Systems) users to enhance their experience while leveraging the inherent diversity in both users' network conditions and field of view (FoV). The key intuition is combining unicast and multicast, for tiled panoramic content, would enable facilitate using the right amount of resources for every tile considering the tile popularity and receiving user link quality. We compare JUMPS performance to state-of-the-art solutions and show that it significantly improves users' received FoV bitrate and reduces their battery by reducing the number of resource blocks that users have to listen to. These results are consistent across various scenarios that vary across user group link conditions, FoV diversity, and available network resources.
Antennas for Nonsinusoidal Waves. I. Radiators (1983)

During the last years numerous applications of nonsinusoidal electromagnetic waves have been discussed in this TRANSACTIONS. The next step is the implementation of these applications. It is generally accepted that the antennas pose the greatest diMculty. In a series of papers on radiators, sensors, and arrays, we will investigate antennas, both theoretically and experimentally. Sufficient information is provided to permit anybody who is equiped for work with pulses of about I-ns duration to build simple radiators and sensors.
Use of Simulation to Tune Race Car Dampers (1994)

<div class="htmlview paragraph">Having a well-balanced suspension in race cars is critical to a team's success in every race series. The ability of the suspension to keep all four tires in contact with the racing surface over bumps and through turns is crucial. A key component controlling these factors is the dampers. One method used to assess the damper performance, besides on track testing, is the four post vibration rig test. This test involves placing the vehicle on a four post test stand that inputs prescribed forces to the four tires. Acceleration measurements are made on the car during this test and frequency response plots can be generated to evaluate the vertical dynamic response of the vehicle.</div> <div class="htmlview paragraph">While very useful, the four post rig testing is expensive both in terms of race team time and costs. This inspired us to develop a computer simulation of this test that would allow the user to quickly run through many damper and suspension configurations and analyze the predicted vertical dynamic response of the vehicle. Both linear and nonlinear computer simulation models were developed, with the nonlinear model using actual force versus velocity characteristics for the dampers as measured from cyclic testing. Simulation results show good correlation between the actual four post vibration testing and simulation results for an IMSA GTP car. The simulations were also used to tune the dampers of an Indy Lights Lola car by altering the existing damper characteristics to get the desired dynamic response of the vehicle. This procedure was used successfully in the 1993 Indy Lights racing series to tune the dampers for the cars of one team.</div>
An Optical/Near-infrared Investigation of HD 100546 b with the Gemini Planet Imager and MagAO (2017)

Abstract We present H band spectroscopic and H α photometric observations of HD 100546 obtained with the Gemini Planet Imager and the Magellan Visible AO camera. We detect H band emission at the location of the protoplanet HD 100546 b, but show that the choice of data processing parameters strongly affects the morphology of this source. It appears point-like in some aggressive reductions, but rejoins an extended disk structure in the majority of the others. Furthermore, we demonstrate that this emission appears stationary on a timescale of 4.6 years, inconsistent at the 2 σ level with a Keplerian clockwise orbit at 59 au in the disk plane. The H band spectrum of the emission is inconsistent with any type of low effective temperature object or accreting protoplanetary disk. It strongly suggests a scattered-light origin, as this is consistent with the spectrum of the star and the spectra extracted at other locations in the disk. A non-detection at the 5 σ level of HD 100546 b in differential H α imaging places an upper limit, assuming the protoplanet lies in a gap free of extinction, on the accretion luminosity of 1.7 × 10 −4 L ⊙ and for 1 R Jup . These limits are comparable to the accretion luminosity and accretion rate of T-Tauri stars or LkCa 15 b. Taken together, these lines of evidence suggest that the H band source at the location of HD 100546 b is not emitted by a planetary photosphere or an accreting circumplanetary disk but is a disk feature enhanced by the point-spread function subtraction process. This non-detection is consistent with the non-detection in the K band reported in an earlier study but does not exclude the possibility that HD 100546 b is deeply embedded.
Loss Prediction of Medium Voltage Power Modules: Trade-offs between Accuracy and Complexity (2019)

Advances in high breakdown voltage SiC MOSFETs allows design of medium voltage power modules with simpler topologies, however, high dv/dt in addition to high di/dt makes parasitics of power modules more important to consider in loss estimations. Correct estimations can help prevent costly and time-consuming problems in a design process. Data sheet values can be used directly for loss estimation, but more detailed approaches in using device-level SPICE model fitting and inclusion of power module parasitics will give a more detailed estimation and may be used to predict transient behavior at a cost of increased complexity. This paper will quantitatively compare the switching loss predictive capability of different approaches in the case study of a custom-built medium voltage power module for varying operating conditions. It is found that by including parasitics loss prediction error is reduced from 15-25% to a few percent at high DC-link voltage for the case-study chosen.
THE SUPER-ACO FREE ELECTRON LASER SOURCE (2000)

A Free Electron Laser (FEL) source has been implemented on the storage ring Super-ACO in Orsay (France), dedicated for synchrotron radiation, since 1988. Dynamics studies were performed in the longitudinal direction and the transverse plane, leading to an analysis of the FEL intrinsic evolution and the interaction between the FEL and the positron beam. As a longitudinal feedback has been implemented, source stability issues are discussed. In addition, the optical FEL performances are clearly related to the characteristics of the employed mirrors, and the results of systematic studies lead to operation of the FEL at shorter wavelengths. Finally, a user program has been initiated in 1993, using one color with only the FEL or two colors, employing FEL and synchrotron radiation, for pump-probe experiments in biology, surface science and physical-chemistry. 1 HISTORY
Implication of a New Molecule IK in CD34+ Hematopoietic Progenitor Cell Proliferation and Differentiation (1997)

HLA-DR is one of the markers associated with hematopoietic cell differentiation, since expression of this molecule is modulated throughout hematopoiesis. We have previously described and cloned the gene encoding factor IK, which inhibits both interferon gamma (IFN-gamma)-induced and constitutive HLA-DR expression. The current study demonstrates that IK gene transcripts are present in CD34+ cells purified from human umbilical cord blood. IK expression increased and was therefore inversely correlated with the gradual loss of HLA-DR during growth factor-induced CD34+ cell proliferation and differentiation. To study the possible role of IK in hematopoiesis, antisense probes were used. IK expression was specifically inhibited by an antisense oligodeoxynucleotide containing two phosphorothioate internucleotide linkages at each of the 3' and 5' ends and corresponding to the initiation site of IK mRNA. A control oligonucleotide was also tested in parallel. A specific decrease of IK transcripts was correlated with an increase of HLA-DR antigen expression level. In colony-forming assays, IK antisense oligonucleotide inhibited colony formation by multilineage early erythroid and granulomonocytic CD34+ progenitors. The mean colony size was decreased 70% by IK antisense oligonucleotide in comparison to controls. These results provide evidence that the IK molecule participates in the regulation of HLA-DR expression on hematopoietic cells and plays a role in growth factor-dependent CD34+ cell proliferation and differentiation by modulating HLA-DR expression.
Electroreflectance of indium gallium arsenide phosphide lattice matched to indium phosphide (1980)

We report the first systematic measurement of the electroreflectance spectra of InuGa1−uPvAs1−v over the range of compositions that lattice-match InP substrates, at room temperature and for energies between 0.7 and 3.5 eV. Analysis of the spectra has enabled us to determine the composition dependence of E0, E0+Δ0, E1, E1+Δ1, Δ0, and Δ1. Experimentally determined values of E0, E0+Δ0, and m*/m0 have been used to predict the values of the g factors for these compounds.
Minimum-error linear receivers for ill-conditioned MIMO channels (2003)

We address the problem of robustness of linear MIMO receivers in the presence of detrimental effects such as correlation and Rician components. We derive a scheme allowing a approximate closed-form solution for the minimum error-rate (MER) receiver estimation. The solution is a good approximation to the the true MER receiver upon fulfillment of a certain, easily checkable, channel-related condition. The performance gain compared to that MMSE is evaluated for various correlated and Rician channels and transmit power allocation strategies.
Influences of Ventricular Assist Device Pumping on Blood Coagulation (1989)

A left ventricular assist device (VAD) with a smooth surface of segmented polyurethane was implanted in five goats for 10-55 days, and plasma levels of fibrinogen (Fg), prekallikrein (PK), fibrinogen, fibrin degradation products (FDP), antithrombin III (AT III), prothrombin time (PT), partial thromboplastin time (PTT), platelet (Pl) count, and platelet aggregation (PlAg) induced by adenosine diphosphate were measured during the experiment. Heparin was administered during surgery and no systemic antithrombotic therapy was given thereafter. Before the third postoperative day (POD), plasma levels of Fg and PK were at their lowest, and increased afterward. Between the second and fifth POD PT and PTT increased to 130-160%, and returned to normal gradually. Plasma FDP appeared on the second POD and reached peak values of 10-40 micrograms/ml on the sixth POD. Platelet and AT III levels showed no uniform tendency, but the rate of PlAg decreased to levels of 6-77% before the fifth POD and remained low at approximately 80%, influenced by the pumping even after the 25th POD. In summary, VADs themselves activated coagulation and induced consumption coagulopathy to some degree. However, most of the parameters returned to normal within 2 weeks.
The Application of RNA Transcript Conformation Polymorphism in Resolving Mixed Infection of PVY Isolates (2004)

A method based on RNA-transcript conformation polymorphism (TCP) was tested for detection of two PVY isolates in a mixed infection. Differences in electrophoretic mobility of RNA transcripts copied from PCR products of each virus isolate enabled the distinction between the two virus isolates in a mixed infection. The identities of the RNA transcripts and hence of the infecting virus isolates were determined by annealing to reference oligonucleotides containing unique strain-specific sequences visualized by retardation of transcript mobility in gel. The ratio at which both virus isolates could be detected was as low as 1:10. The suitability of this procedure for the study of mixed virus infections is discussed.
An HBT unilateral model to design distributed amplifiers (1999)

A novel heterojunction bipolar transistor (HBT) unilateral model oriented to a fast prediction of the performance of HBT monolithic-microwave integrated-circuit distributed amplifiers is proposed. The HBT unilateral model includes, by simple expressions, the effects caused by the HBT parasitics. A graphical design procedure for HBT distributed amplifiers is also proposed. This method is based on a set of generalized charts and represents a simple and fast design tool for designers. Comparisons between the performance of specially designed HBT distributed amplifiers and the results obtained using the HBT unilateral model demonstrate the validity of the proposed approach.
Increased GADD gene expression in human colon epithelial cells exposed to deoxycholate (2004)

The colonic epithelium is often exposed to high concentrations of secondary bile acids, which stresses the epithelial cells, leading potentially to activation of stress-response genes. To examine this possibility in vitro, the purpose of this study was to determine if expression of certain growth arrest and DNA damage-inducible genes (GADD) is upregulated in human colonic epithelial cells exposed to deoxycholate (DOC). DNA macroarray screening of a small cluster of stress/apoptosis-related genes in DOC-treated HCT-116 colonocytes revealed clearly higher expression of only GADD45, which was confirmed by gene-specific relative RT-PCR analysis. Subsequently, it was found that DOC also increased GADD34 mRNA expression. However, mRNA expression of GADD153 was increased most markedly in DOC-treated HCT-116 colonocytes, which express wild-type p53. However, the upregulation of GADD34, GADD45, and GADD153 mRNA expression apparently did not require p53, based on the finding that DOC increased expression of all three GADD genes in HCT-15 colonocytes, which express mutant p53. In further studying GADD153 in particular, the effect of DOC on GADD153 mRNA was prevented by actinomycin-D (Act-D), but not by antioxidants or MAPK inhibitors. DOC also caused GADD153 protein to be expressed in close parallel with increased GADD153 mRNA expression. Induction of GADD153 protein by DOC was prevented by either anisomycin or cycloheximide. These findings suggest that DOC-induced upregulation of GADD153 mRNA expression occurred at the level of transcription without involving reactive oxygen species and MAPK signaling, and that the expression of GADD153 protein was due also to translation of pre-existing, and not just newly synthesized, mRNA.
Performance of Doppler estimation for acoustic sources with atmospheric scattering (2004)

A statistical analysis of differential Doppler estimation is presented for acoustic sources with a harmonic spectrum. Our model for the sensor measurements includes a physics-based statistical model for the scattering of the wavefronts by the atmosphere. We derive the Cramer-Rao bound (CRB) on differential Doppler estimation as a function of the atmospheric conditions, the frequency of the source, and the range of the source. We apply the CRB result for several cases of interest with simulated and measured data.
Substrate Profiling of Mitochondrial Caseinolytic Protease P via a Site‐Specific Photocrosslinking Approach (2021)

Abstract Approaches for profiling protease substrates are critical for defining protease functions, but remain challenging tasks. We combine genetic code expansion, photocrosslinking and proteomics to identify substrates of the mitochondrial (mt) human caseinolytic protease P (hClpP). Site‐specific incorporation of the diazirine‐bearing amino acid DiazK into the inner proteolytic chamber of hClpP, followed by UV‐irradiation of cells, allows to covalently trap substrate proteins of hClpP and to substantiate hClpP's major involvement in maintaining overall mt homeostasis. In addition to confirming many of the previously annotated hClpP substrates, our approach adds a diverse set of new proteins to the hClpP interactome. Importantly, our workflow allows identifying substrate dynamics upon application of external cues in an unbiased manner. Identification of unique hClpP‐substrate proteins upon induction of mt oxidative stress, suggests that hClpP counteracts oxidative stress by processing of proteins that are involved in respiratory chain complex synthesis and maturation as well as in catabolic pathways.
Two Mechanisms of Slow Host-Guest Complexation between Cucurbit[6]uril and Cyclohexylmethylamine: pH-Responsive Supramolecular Kinetics (2001)

20 times more rapid is the complexation of the organic ammonium ion receptor cucurbit[6]uril (CB6) with cyclohexylmethylamine than with the cyclohexylmethylammonium species. Within the narrow pH region around the pK<sub>a</sub> value of the amine, the complexation kinetics are accelerated but the binding constant remains essentially unaffected. In this region, the ammonium complex is formed through binding of the amine form followed by fast protonation and not through direct complexation of the ammonium form. Molecular dynamics calculations suggest that the amine form undergoes a direct inclusion into CB6 while the ingression of the ammonium form is retarded by the formation of an association complex, which reacts through a different, higher lying transition state to the inclusion complex.
Antiangiogenic effects of the novel camptothecin ST1481 (gimatecan) in human tumor xenografts. (2003)

ST1481 (gimatecan) is a novel lipophilic camptothecin with a promising preclinical pharmacological profile. On the basis of its high antitumor efficacy when delivered by the oral route, the compound is suitable for prolonged administration. This schedule of treatment has been reported as the most appropriate to exploit the antiangiogenic effects of cytotoxic drugs. The aim of the study was to investigate the antiangiogenic and antitumor effects of oral ST1481 in human tumor xenografts. In spite of a marginal drug effect against the s.c. growing A549 lung carcinoma following administration with an intermittent schedule (q4dx4 times, maximum tolerated dose: 2 mg/kg), tumor growth was strongly inhibited by a daily low-dose (0.5 mg/kg) prolonged administration. Immunohistochemical analysis showed a reduced number of microvessels in tumors of both treated groups versus controls and a significantly higher reduction in the daily versus the q4dx4-treated tumors (P < 0.0001, by Student's t test). In our experimental model, the relation between microvessel density and tumor size (r = 0.738, by the Spearman rank test) suggests a role of inhibition of tumor vasculature in tumor response. Significant inhibition of tumor angiogenesis (P < 0.0001 versus control tumors) was observed even with a very low drug dose (0.06 mg/kg) in the orthotopically implanted (i.d.) MeWo melanoma, under conditions causing minimal tumor growth inhibition. Additional evidences of the antiangiogenic activity of ST1481 were provided by antimotility effects on endothelial cells, in vivo inhibition of vascularization in the Matrigel assay, and down-regulation of the expression of the proangiogenic basic fibroblast growth factor in A549 tumor cells associated with inhibition of the pathway involving Akt. In conclusion, the available results support the possibility that the antiangiogenic properties of ST1481 contribute to its antitumor potential and that this effect might be enhanced by the continuous low-dose treatment.
Management of Primary Hyperparathyroidism (1993)

Primary hyperparathyroidism is a common disease that can be accurately diagnosed and effectively treated in most patients. The diagnosis is established by a persistent elevation of serum calcium and parathyroid hormone and by clinical evaluation. Surgery is the appropriate treatment, and preoperative localization procedures are seldom indicated. Selected patients with mild disease may be followed by procedures devised to identify deterioration of skeletal, neurological, and renal function. The accurate diagnosis and effective treatment of primary hyperparathyroidism are rewarding clinical experiences for the endocrinologist and surgeon.
[Prevalence of serum anti-hepatitis C virus antibodies and risk factors of contamination in the personnel of a hospital in the Paris region. A prospective survey]. (1996)

These results suggest the importance of systematic anti-HCV screening among health care workers particularly those in contact with patients.
Conditional probability density function estimation with sigmoidal neural networks (1999)

Real-world problems can often be couched in terms of conditional probability density function estimation. In particular, pattern recognition, signal detection, and financial prediction are among the multitude of applications requiring conditional density estimation. Previous developments in this direction have used neural nets to estimate statistics of the distribution or the marginal or joint distributions of the input-output variables. We have modified the joint distribution estimating sigmoidal neural network to estimate the conditional distribution. Thus, the probability density of the output conditioned on the inputs is estimated using a neural network. We have derived and implemented the learning laws to train the network. We show that this network has computational advantages over a brute force ratio of joint and marginal distributions. We also compare its performance to a kernel conditional density estimator in a larger scale (higher dimensional) problem simulating more realistic conditions.
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3 (2003)

GRIM-19 (gene associated with retinoid-IFN-induced mortality 19), isolated as a cell death activator in a genetic screen used to define mechanisms involved in IFN-beta- and retinoic acid-induced cell death, codes for a approximately 16-kDa protein that induces apoptosis in a number of cell lines. Antisense ablation of GRIM-19 caused resistance to cell death induced by IFN plus retinoic acid and conferred a growth advantage to cells. To understand the molecular bases for its cell death regulatory activity, we used a yeast two-hybrid screen and identified that the transcription factor STAT3 (signal transducer and activator of transcription 3) binds to GRIM-19. GRIM-19 inhibits transcription driven by activation of STAT3, but not STAT1. It neither inhibits the ligand-induced activation of STAT3 nor blocks its ability to bind to DNA. Mutational analysis indicates that the transactivation domain of STAT3, especially residue S727, is required for GRIM-19 binding. Because GRIM-19 does not bind significantly to other STATs, our studies identify a specific inhibitor of STAT3. Because constitutively active STAT3 up-regulates antiapoptotic genes to promote tumor survival, its inhibition by GRIM-19 also demonstrates an antioncogenic effect exerted by biological therapeutics.
Synthesis of the North 1 Unit of the Cephalostatin Family from Hecogenin Acetate<sup>1</sup> (1999)

Hecogenin acetate (1) was converted to North 1 azidoketone 5 involving several key transformations: (1) conversion of cyclic sulfate 33b to allylic alcohol 40 via Reich iodoso olefination; (2) E-ring annulation via intermolecular oxygen alkylation of highly functionalized secondary alcohol 40 using rhodium-catalyzed decomposition of an α-diazophosphonoacetate to provide α-alkoxyphosphonoacetate 52, with subsequent intramolecular Wadsworth−Emmons reaction to provide alkoxydihydrofuran 53; and (3) establishment of the C20 stereochemistry by chromium(II) reduction of tertiary bromide 86 to a 9:1 mixture of diastereomeric spiroketals 90α/90β, separated as silyl ethers 91α/91β. Conversion of 91α to α-azidoketone 5 was uneventful.