gebhart/patrepeval huggingface dataset:
Platelet binding properties of monoclonal lupus autoantibodies produced by human hybridomas (1985)

The platelet binding properties of human monoclonal lupus autoantibodies have been studied. These IgM autoantibodies, produced by human X human hybridomas derived from lymphocytes of patients with systemic lupus erythematosus, are known to bind to single-stranded DNA. Four anti-DNA antibodies that express the dominant 16/6 idiotype--HF2′1/17, HF2′18/2, HF2′1/13b, and HF3′16/6--bound to glutaraldehyde-fixed platelets. In contrast, HF6′21/28, HF9′11/3, and polyclonal IgM bound poorly to platelets. [35S]Methionine was incorporated into HF2′1/17, and the interaction of the intrinsically radiolabeled HF2′1/17 with fixed platelets was evaluated in a solution phase radioimmunoassay. [35S]Methionine HF2′1/17 bound to fixed platelets and could be displaced by equivalent amounts of HF2′1/17, HF2′18/2, HF2′1/13b, and HF3′16/6. HF2′1/17 bound with greater affinity to fresh platelets and to thrombin-activated platelets than to glutaraldehyde-fixed platelets. Single-stranded DNA competed with platelets for the HF2′1/17 combining site. Treatment of fresh platelets with nuclease I, trypsin, chymotrypsin, and neuraminidase did not alter the binding of antibody to the platelet surface. No binding of antibody to phospholipid micelles was observed. Purified IgM autoantibodies did not inhibit platelet aggregation induced with ADP, thrombin, or ristocetin in platelet-rich plasma. These results indicate that the human IgM monoclonal anti-DNA autoantibodies that express the dominant 16/6 idiotype are polyspecific, bind to platelets, and interact with a platelet epitope that does not appear to involve DNA, protein, or sialic acid. These antibodies interact with platelets through the same sites responsible for antibody-DNA binding.
Anomalous thermal expansion of silver gallium telluride (1981)

A precise X-ray determination of the lattice parameters of silver gallium telluride, AgGaTe2, has been made in the temperature range 301 to 667 K with a Unicam 190 mm high-temperature powder camera. The data have been used to evaluate the coefficients of thermal expansion, α⊥ and α\parallel, at various temperatures. It has been observed that the `c' parameter decreases while the `a' parameter increases with increasing temperature as in the case of AgGaSe2 and AgGaS2, which also have a chalcopyrite-type structure. The magnitudes of both α⊥ and α\parallel increase non-linearly with increasing temperature.
Ideal seeds harvest moment of different maize hybrids (2014)

The aim of this study was to identify the ideal maize seed harvest moment by different characteristics, as black layer formation, milk line development, seed moisture content and seed dry matter accumulation. Three simple hybrids from Syngenta Company were used in this work; ears from plants in the same development stage were collected, the first harvesting began 40 days after flowering, at four days interval until all seeds in an ear had the black layer formation. The characteristics evaluated were: black layer formation, milk line development, seed moisture content and seed dry matter. Seed physiological quality was evaluated by germination test, cold test, accelerated ageing and electrical conductivity. Results obtained in this study showed that the best indicative to identify the ideal maize seeds harvest moment is milk line stage 4 (75% of solidified endosperm). This stage occurs at different time for each genotype studied, 60DAF to hybrids 1 and 3, and 52DAF to hybrid 2, due to genetic differences among the hybrids.
Micromechanics of Surfaces: Role of Surface Roughness in Hysteresis During Adhesive Elastic Contact (2011)

In experiments that involve contact with adhesion between two surfaces, as found in atomic force microscopy or nanoindentation, two distinct contact force (P ) vs. indentation-depth (h) curves are often measured depending on whether the indenter moves towards or away from the sample. The origin of this hysteresis is not well understood and is often attributed to moisture, plasticity or viscoelasticity. We present experiments [1] and continuum mechanics models [2] that will show that hysteresis can exist without these effects, and that its magnitude depends on surface roughness. We explain the observed hysteresis as the smeared out effect of a large series of surface instabilities that are induced by the surface’s roughness and adhesion. These instabilities cause the size of the nominal contact region to be significantly different during the loading and the unloading phases of the contact experiment. We also demonstrate that when this is the case material properties can be estimated uniquely from contact experiments even when the measured P -h curves are not unique. The hysteresis energy loss during contact is also a measure of the adhesive toughness of the contact interface. We show experimentally that roughness can both increase and decrease the adhesive toughness of the contact interface. We show through numerical simulation of continuum adhesive contact models that the contact interface is optimally tough at conditions at which the contact region is at the cusp of the transition at which it turns from being mostly simply connected to being predominantly multiply connected. This insight is useful in increasing an interface’s toughness by modifying its small scale structure through microfabrication techniques.
Noble Gas Endohedral Complexes of C<sub>60</sub> Buckminsterfullerene (1997)

Equilibrium geometries and binding energies (corrected for basis set superposition error) of single and multiple noble gas atom complexes of C60 are calculated at DFT and MP2 levels of theory using basis sets including polarization functions. B3LYP and MP2 give similar van der Waals dispersion interactions, predicting repulsive energies for the He and Ne complexes of about 1 kcal/mol, and higher energies for the larger noble gas atom complexes. As expected, C60 is resilient to deformation in all cases studied, with the geometry of the fullerene cage barely affected by the presence of multiple noble gas atoms inside.
Accelerating fractal image compression by multi-dimensional nearest neighbor search (2002)

In fractal image compression the encoding step is computationally expensive. A large number of sequential searches through a list of domains (portions of the image) are carried out while trying to find the best match for another image portion. Our theory developed here shows that this basic procedure of fractal image compression is equivalent to multi-dimensional nearest neighbor search. This result is useful for accelerating the encoding procedure in fractal image compression. The traditional sequential search takes linear time whereas the nearest neighbor search can be organized to require only logarithmic time. The fast search has been integrated into an existing state-of-the-art classification method thereby accelerating the searches carried out in the individual domain classes. In this case we record acceleration factors from 1.3 up to 11.5 depending on image and domain pool size with negligible or minor degradation in both image quality and compression ratio. Furthermore, as compared to plain classification our method is demonstrated to be able to search through larger portions of the domain pool without increased the computation time.
The management of seabed living resources in "the Area" under UNCLOS (2006)

In the challenging and fascinating world of the deep seabed, important developments in the technology for seabed exploration and exploitation took place during the negotiations of the III United Nations Conference on the Law of the Sea (1973-1982). Many other occurred after the adoption of the Convention (UNCLOS). All these developments provided unexpected knowledge of the wealth of the deep ocean.
A Vaccine That Co-Targets Tumor Cells and Cancer Associated Fibroblasts Results in Enhanced Antitumor Activity by Inducing Antigen Spreading (2013)

Dendritic cell (DC) vaccines targeting only cancer cells have produced limited antitumor activity in most clinical studies. Targeting cancer-associated fibroblasts (CAFs) in addition to cancer cells may enhance antitumor effects, since CAFs, the central component of the tumor stroma, directly support tumor growth and contribute to the immunosuppressive tumor microenvironment. To co-target CAFs and tumor cells we developed a new compound DC vaccine that encodes an A20-specific shRNA to enhance DC function, and targets fibroblast activation protein (FAP) expressed in CAFs and the tumor antigen tyrosine-related protein (TRP)2 (DC-shA20-FAP-TRP2). DC-shA20-FAP-TRP2 vaccination induced robust FAP- and TRP2-specific T-cell responses, resulting in greater antitumor activity in the B16 melanoma model in comparison to monovalent vaccines or a vaccine encoding antigens and a control shRNA. DC-shA20-FAP-TRP2 vaccination enhanced tumor infiltration of CD8-positive T cells, and induced antigen-spreading resulting in potent antitumor activity. Thus, co-targeting of tumor cells and CAFs results in the induction of broad-based tumor-specific T-cell responses and has the potential to improve current vaccine approaches for cancer.
Concise Review: A High-Content Screening Approach to Stem Cell Research and Drug Discovery (2012)

High-throughput screening (HTS) is a technology widely used for early stages of drug discovery in pharmaceutical and biotechnology industries. Recent hardware and software improvements have enabled HTS to be used in combination with subcellular resolution microscopy, resulting in cell image-based HTS, called high-content screening (HCS). HCS allows the acquisition of deeper knowledge at a single-cell level such that more complex biological systems can be studied in a high-throughput manner. The technique is particularly well-suited for stem cell research and drug discovery, which almost inevitably require single-cell resolutions for the detection of rare phenotypes in heterogeneous cultures. With growing availability of facilities, instruments, and reagent libraries, small-to-moderate scale HCS can now be carried out in regular academic labs. We envision that the HCS technique will play an increasing role in both basic mechanism study and early-stage drug discovery on stem cells. Here, we review the development of HCS technique and its past application on stem cells and discuss possible future developments.
Imine-Linked Porous Polymer Frameworks with High Small Gas (H<sub>2</sub>, CO<sub>2</sub>, CH<sub>4</sub>, C<sub>2</sub>H<sub>2</sub>) Uptake and CO<sub>2</sub>/N<sub>2</sub> Selectivity (2013)

A series of novel porous polymer frameworks (PPFs) with [3 + 4] structure motif have been synthesized from readily accessible building blocks via imine condensation, and the dependence of gas adsorption properties on the building block dimensions and functionalities was studied. The resulting imine-linked frameworks exhibit high surface area: the Brunauer–Emmett–Teller (BET) specific surface area up to 1740 m2 g–1, and a Langmuir surface area up to 2157 m2 g–1. More importantly, the porous frameworks exhibit outstanding H2 (up to 2.75 wt %, 77 K, 1 bar), CO2 (up to 26.7 wt %, 273 K, 1 bar), CH4 (up to 2.43 wt %, 273 K, 1 bar), and C2H2 (up to 17.9 wt %, 273 K, 1 bar) uptake, which are among the highest reported for organic porous materials. PPFs exhibit good ideal selectivities for CO2/N2 (14.5/1–20.4/1), and CO2/CH4 adsorption (8.6/1–11.0/1), and high thermal stabilities (up to 500 °C), thus showing a great potential in gas storage and separation applications.
Photoluminescence and cathodoluminescence studies of stoichiometric and oxygen-deficient ZnO films (2001)

Photoluminescence and cathodoluminescence (CL) spectra of stoichiometric and oxygen-deficient ZnO films grown on sapphire were examined. It was found that the intensities of the green and yellow emissions depend on the width of the free-carrier depletion region at the particle surface; the thinner the width, the larger the intensity. Experimental results and spectral analyses suggest that the mechanism responsible for the green (yellow) emission is the recombination of a delocalized electron close to the conduction band with a deeply trapped hole in the single ionized oxygen vacancy Vo+ (the single negatively charged interstitial oxygen ion Oi−) center in the particle.
Fermentation of Fructooligosaccharides and Inulin by Bifidobacteria: a Comparative Study of Pure and Fecal Cultures (2005)

The utilization of fructooligosaccharides (FOS) and inulin by 55 Bifidobacterium strains was investigated. Whereas FOS were fermented by most strains, only eight grew when inulin was used as the carbon source. Residual carbohydrates were analyzed by high-performance anion-exchange chromatography with pulsed amperometric detection after batch fermentation. A strain-dependent capability to degrade fructans of different lengths was observed. During batch fermentation on inulin, the short fructans disappeared first, and then the longer ones were gradually consumed. However, growth occurred through a single uninterrupted exponential phase without exhibiting polyauxic behavior in relation to the chain length. Cellular beta-fructofuranosidases were found in all of the 21 Bifidobacterium strains tested. Four strains were tested for extracellular hydrolytic activity against fructans, and only the two strains which ferment inulin showed this activity. Batch cultures inoculated with human fecal slurries confirmed the bifidogenic effect of both FOS and inulin and indicated that other intestinal microbial groups also grow on these carbon sources. We observed that bifidobacteria grew by cross-feeding on mono- and oligosaccharides produced by primary inulin intestinal degraders, as evidenced by the high hydrolytic activity of fecal supernatants. FOS and inulin greatly affected the production of short-chain fatty acids in fecal cultures; butyrate was the major fermentation product on inulin, whereas mostly acetate and lactate were produced on FOS.
The U.S.-Mexico Tax Treaty: Its Relation to NAFTA and Its Status (1993) (2010)

Issue one focused on the Problems and Prospects of a North American Free Trade Agreement.
Macromol. Chem. Phys. 6/2007 (2007)

Cover: The picture illustrates a strategy for the preparation of cellulose hydrated membrane via pre‐gelation processing and the interesting surface and bulk structure of the membrane. Further details can be found in the Full Paper S. Liang, L. Zhang, * Y. Li, and J. Xu * on page 594.
Multigigabit optical packet switch for self-routing networks with subcarrier addressing (1992)

Very high-speed packet networks will be required in the near future to efficiently integrate data, video, and voice into a common telecom-munications fabric. Many existing and proposed packet networks fail to take advantage of the multigigabit bandwidths provided by optical fiber and semiconductor optoelectronics. Much of the disparity between the data transfer rate of traditional packet networks (≤1 Gbit/s) and the link transmission rates for conventional lightwave systems (as high as 10 Gbit/s) lies in the amount of electronic processing that occurs at each node. A number of methods have been suggested to overcome this bottleneck. Many of these solutions rely on providing optical connectivity through the network without full optical-to-electronic (OE) and electronic-to-optical (EO) conversion of the packet at each node.
Control of Secretory Leukocyte Protease Inhibitor Gene Expression in the Porcine Periimplantation Endometrium: A Case of Maternal-Embryo Communication1 (1998)

The contributions of the conceptus (embryo and associated membranes) and of the maternal endocrine milieu to control of endometrial secretory leukocyte protease inhibitor (SLPI, also designated antileukoproteinase) expression during the periimplantation stages of embryo development were examined in the present study. Uterine endometrium from distinct sites was collected from pigs at Days 16-25 of pregnancy and analyzed for steady-state SLPI mRNA levels. Endometrium situated directly beneath conceptuses (mesometrial) had greater (p < 0.05) SLPI mRNA levels than that obtained from antimesometrial and interimplantation sites and myometrium. This site-specific difference was most pronounced during late (Days 19-21) and post (Days 23-25)-implantation stages and was also observed, albeit to a lesser degree, for the mRNA encoding uteroferrin (Uf). Conditioned medium (CM; 50% v:v) from Day 21, but not Day 12, conceptuses increased (p < 0.05) SLPI mRNA levels, while neither CM affected mRNA levels for Uf and several other genes expressed in endometrial explants. One inducing factor in Day 21 CM was characterized as a low-molecular-mass (< 12 kDa), relatively heat-stable protein. Transforming growth factor (TGF alpha) increased (p < 0.05), epidermal growth factor (EGF) tended to increase (p = 0.10), and insulin-like growth factor (IGF)-I and IGF-II had no effect (p > 0.10) on, SLPI mRNA levels in Day 12 endometrial explants. Medium conditioned by the pig trophoblast cell line, Jag-1, but not by other mammalian cell lines, had SLPI inducer activity. The maternal endocrine contribution to SLPI gene expression was examined using freshly isolated and short-term-cultured Day 12 and Day 21 pregnant pig endometrium. Steady-state SLPI mRNA levels were increased (p < 0.05) in Day 12, but not Day 21, tissues upon short-term culture in serum-free medium. This increase was time dependent, was similarly demonstrated for Uf mRNA, was not observed in corresponding lung and liver, and was inhibited by inclusion of serum from pigs of diverse endocrine status. In summary, two potential modulators of endometrial SLPI gene expression were identified: 1) a conceptus-derived low-molecular-mass protein, possibly TGF alpha, that mediates in part the up-regulation of SLPI gene expression in endometrium closely associated with implantation sites, and 2) an inhibitory component(s) present in maternal serum. Results suggest opposing actions of maternal and embryonic factors at the maternal-embryo interface and highlight involvement of the periimplantation embryo in directing the spatiotemporal expression of endometrial genes implicated in its development.
Mathcad 6.0: a review (1996)

The aim was to examine the association between oral health-related quality of life and loneliness and perceived as well as objective social isolation. Data were used from a nationally representative survey with n = 3075 (late Summer 2021). The established Oral Health Impact Profile (OHIP-G5) was used to quantify oral health-related quality of life. Moreover, established tools were used to quantify the outcome measures (De Jong Gierveld loneliness scale, Bude/Lantermann scale and Lubben Social Network Scale). It was adjusted for several covariates in regression analysis. Linear regressions showed that low oral health-related quality of life is associated with higher loneliness (B = 0.03, <i>p</i> < 0.001), higher perceived social isolation (B = 0.06, <i>p</i> < 0.001) and higher objective social isolation (B = 0.07, <i>p</i> < 0.05). Further regressions were performed (e.g., stratified by denture usage). Our study stressed the importance of low oral health-related quality of life for loneliness and social isolation (both perceived and objective). This knowledge is important to address individuals at risk. Future studies should clarify the underlying mechanisms.
Darbepoetin-alfa in renal-transplant patients: an observational monocentric study (2008)

DA effectively corrected anemia in renal-transplant patients, in previously treated patients and in EPO-naive patients. DA was also found to be well-tolerated.
Heterocyclic photorearrangements. Photochemical behaviour of some 3,5‐disubstituted 1,2,4‐oxadiazoles in methanol at 254 nm (1988)

Abstract Photochemical behaviour of some 3,5‐disubstituted 1,2,4‐oxadiazoles in methanol at 254 nm has been investigated. Ring photoisomerization to the 1,3,4‐oxadiazole heterocycle or formation of open chain compounds involving the nucleophilic solvent was shown to depend on the nature and the position of the substituent. Photoinduced ring closure into the benzimidazole system, involving a 3‐ N ‐phenylamino side chain sequence and a photolytic intermediate of the oxadiazole heterocycle, is also reported.
Immunosuppressive effects of bovine seminal fluid fractions with ribonuclease activity. (1983)

Using different isolation procedures (after acidification and saturation with 3 M ammonium sulphate) three fractions were isolated from bull seminal vesicle fluid and assayed for their effects on cell immunity in vitro and in vivo. Two of these preparations (ZS RNase and AS RNase) possessing a high level of ribonuclease activity at concentrations of 50 micrograms/ml showed inhibitory effects (up to 80%) on 3H-thymidine incorporation into the DNA of mitogen-or antigen-stimulated human lymphocytes. The third preparation (3M-P) possessing low ribonuclease activity showed lesser inhibitory effects. The potency of mouse spleen cells to cause regional GVH reaction was significantly decreased after preincubation of spleen cells to cause of 1 mg per AS RNase or ZS RNase whereas 3M-P was ineffective in this test. A single dose of 1 mg per mouse of ZS RNase or 3M-P administered i.p. on day 4 after skin transplantation significantly prolonged graft rejection. Both preparations at this dose potentiated the effect of cyclophosphamide on skin graft survival. All tested preparations preincubated with mouse bone marrow cells had no adverse effects on their colony-forming activity (in the spleens of irradiated mice). The possibility of utilizing the preparations with ribonuclease activity isolated from vesicle fluid in clinical bone marrow transplantation is discussed.
The relation between motivational patterns and achievement cognitions through the elementary school years (1995)

Among children in fifth and higher grades, the helpless motivational pattern is associated with the idea that intelligence is a fixed entity. Cognitive concommitants of helplessness in younger children, however, are not well understood. To identify developmental relations between motivational patterns and cognitions about ability and achievement, 139 first, third, and fifth graders' beliefs about ability and achievement were assessed, as well as their motivational responses to challenging puzzles. A sizeable minority of children at all ages showed the maladaptive helpless pattern (nonpersistence, negative expectations, etc.). Among older children, the helpless and mastery orientations were associated with differences in whether intelligence was seen as fixed or malleable. Younger children with the helpless pattern gave outcome-oriented explanations for school grades, whereas those with a mastery orientation gave process-oriented explanations
Aroma Composition And Polyphenol Content Of Ciders Available In Latvian Market (2012)

Aroma forming volatiles are important components of fermented beverages. The aim of current research is to evaluate the volatile compounds and phenolic compounds of commercial ciders. Volatile aroma compounds and TPC of seven commercial ciders were determined. Extraction of aroma compounds was performed using solid phase microextraction (DVB/Car/PDMS fibre). Analysis of volatile aroma compounds was made using a Perkin Elmer Clarus 500 GC/MS. Total phenol content (TPC) was determined according to the Folin-Ciocalteu spectrophotometric method and results were expressed as gallic acid equivalents. The highest volatile compounds were in apple ciders with pear flavor. The highest TPC and lower content of volatile compounds were detected in French ciders.