gebhart/patrepeval huggingface dataset:
Studies on the Virus of Venezuelan Equine Encephalomyelitis in Trinidad, W.I. (1962)

SummaryA total of 687 sera from adults and children in three areas of Trinidad were tested for the presence of neutralizing antibodies against VEE virus. In southwestern Trinidad, the area involved in the 1943–1944 epizootic, antibodies were found only in sera from individuals living in 1944. In the Port of Spain area, evidence of post-1944 experience with the virus was very slight. By contrast, in the non-epizootic area of central Trinidad, an appreciable incidence of serological positivity was found in all age groups, including children born after 1944, some even born as late as 1949. Possible explanations for these last findings are discussed. Of these, the most tenable postulates the existence in this area of a well-established focus of VEE virus, or a closely related strain, which produces essentially symptomless infection in man. Possible origins of this focus are considered.
Precision Measurements in Helium at 58 nm: Ground State Lamb Shift and the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mn>1</mml:mn></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msup></mml:mrow></mml:math><i>S</i>-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msup></mml:mrow></mml:math><i>P</i>Transition Isotope Shift (1996)

A source of narrow bandwidth ( $<800\mathrm{MHz}$) tunable laser radiation at 58.4 nm has been developed and is applied to record the $^{1}1S\ensuremath{-}^{1}2P$ transition in ${}^{3}$He and ${}^{4}$He. From the ${}^{4}$He transition frequency of $171134.8936(58){\mathrm{cm}}^{\ensuremath{-}1}$ a fivefold improved ground state Lamb shift of $1.3763(58){\mathrm{cm}}^{\ensuremath{-}1}$ is deduced, in good agreement with the theoretical value of $1.3755(10){\mathrm{cm}}^{\ensuremath{-}1}$. The measured $^{1}1S\ensuremath{-}^{1}2P$ transition isotope shift of 263 410(7) MHz presents a more than 2 order of magnitude improvement over a previous value and agrees with a theoretical value of 263 411.26(11) MHz.
Inhibition of HIV-1-Induced Syncytia Formation and Infectivity by Lipophosphoglycan from Leishmania (1995)

Summary: In HIV-1 infection, the appearance of syncytia-inducing (SI) isolates is associated with a more rapid decline of CD4+ cells and progression to AIDS. Agents that inhibit either virus infection or syncytia formation have the potential to be therapeutically useful. Lipophosphoglycan (LPG), the major glycoconjugate of Leishmania, was recently shown to be a potent nonspecific inhibitor of viral membrane fusion. In this study, LPG demonstrated a dosedependent inhibition of HIV-1-induced syncytia formation in CD4 + MT-2 cells infected with distinct SI isolates. Fragments of LPG were used to show that inhibition of syncytia formation was dependent on the length of the LPG fragment. Treatment of CD4+ cells or HIV-1 isolates with LPG inhibited infection in vitro. Furthermore, LPG inhibited the replication of SI viral isolates in CD4+ T cells in vitro. LPG had no toxic effects on peripheral blood mononuclear cells at the highest concentrations used in these assays. Further, LPG rapidly associated with the surface membrane of a human T cell line and subsequently disassociated over a 24-h period. The development of compounds capable of inhibiting HIV-induced syncytia formation should provide novel therapeutic approaches to control the spread of virus and disease progression.
A complete fronthaul CWDM single fiber solution including improved monitoring scheme (2015)

Fronthaul is a network segment between Remote Radio Head (RRH) situated on the antenna site, and the Base Band Unit (BBU) localized in the Central Office. It uses the Common Public Radio Interface protocol (CPRI). A point to point physical topology can be used, but the deployment of this configuration uses a lot of optical resources. Coarse Wavelength Division Multiplexing (CWDM) dual fiber and single fiber links can be used to reduce the number of optical fibers. This paper focuses on the single fiber links because in addition to others advantages of this system, it uses less fiber than the CWDM dual fiber system. The difficulty to build a complete fronthaul single fiber solution is to provide a monitoring system in addition to CPRI data transport. We propose to characterize, in terms of Bit Error Rate (BER) CPRI requirements, a fronthaul CWDM single fiber link up to 4.9 Gbits/s. Furthermore, an innovative single fiber monitoring scheme, based on the reduction of Rayleigh Backscattering light in the fiber is illustrated. This reduction is carried out due to the combination of a Polarization Beam Combiner and a Faraday Rotator Mirror. This reduction allows improving the capacity of failure detection of the fiber in the CWDM single fiber technology.
Use of digitalis in the treatment of heart failure: data from the Italian Network on Congestive Heart Failure (IN-CHF). (2004)

Over 60% of Italian outpatients with HF were treated with digitalis; as expected, patients with a low ejection fraction, atrial fibrillation and in a more advanced stage of HF are more likely to receive this drug. Finally, after the publication of the DIG trial, the rate of digitalis prescription significantly decreased.
Anti-cancer therapy related hand-foot syndrome in patients with systemic sclerosis: Case series and literature review (2020)

Hand-foot syndrome (HFS) is a common chemotherapy side effect, typically managed with supportive care including preemptive cooling. Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular dysfunction and fibrosis of multiple organs, including the hands, which can result in acro-osteolysis and sclerodactyly. Here we discuss the management of two patients with SSc and concomitant HFS: A woman in her 70′s with pancreatic cancer treated with paclitaxel and gemcitabine, and a woman in her 40′s with breast cancer treated with capecitabine. Potential strategies for managing HFS in patients with SSc include maximizing vasodilation (with calcium channel blockers or phosphodiesterase type 5 inhibitors), excellent wound care and potentially antibiotics if finger ulcerations develop, considering limiting hand cooling during taxane treatments, and possible dose reduction of chemotherapy due to HFS if finger ulcerations and pain become dose-limiting.
Isolation of Tetranucleotide Repeat Polymorphisms Flanking theBRCA1Gene (1996)

Large pools of cosmids from the BRCA1 region of human chromosome 17 were screened for tetranucleotide repeat polymorphisms by hybridizing shotgun subcloned pools with a mixture of 25 oligonucleotides. Identified subclones were PCR amplified and directly sequenced to design PCR primers for short tandem repeat polymorphism (STRP) analysis of family DNAs. With the identification of the BRCA1 gene and the observation that most mutations in this > 100-kb gene are unique, haplotyping and linkage analysis may play a significant role in diagnosis and carrier detection of BRCA1-associated breast and ovarian cancers. We report the characterization of 15 new STRPs flanking the BRCA1 locus.
Design and investigation of 3D microwave devices manufactured under the low-temperature co-fired ceramic process (2003)

This report describes the opportunities presented by the LTCC technology, its implementation and its practical application in the manufacture of 3D microwave devices.
USE OF RHEOLOGICAL AND OTHER DATA IN ASPHALT ENGINEERING PROBLEMS (1958)

THE PERFORMANCE IN SERVICE OF ASPHALTS IN VARIOUS SYSTEMS DEPENDS BOTH ON THE INFLUENCE TO WHICH THE MATERIAL IS SUBJECTED AND THE INTRINSIC PROPERTIES OF THE ASPHALT ITSELF. A WIDE VARIETY OF ASPHALTS HAS BEEN INVESTIGATED WITH RESPECT TO (1) THEIR RHEOLOGICAL BEHAVIOR UNDER BOTH STATIC AND DYNAMIC LOAD, (2) THEIR BREAKING PROPERTIES, AND (3) OTHER PROPERTIES SUCH AS WATER PERMEABILITY, PHOTOCHEMICAL DECOMPOSITION, ETC. THE RHEOLOGICAL DATA ARE CONDENSED TO GENERALIZED CURVES OF BOTH THE DYNAMIC STORAGE AND LOSS MODULI VERSUS FREQUENCY, THE TEMPERATURE DEPENDENCE OF THESE CURVES, AND THE DEPENDENCE OF THE INITIAL VISCOSITY ON TEMPERATURE. BY THE USE OF THE SOFTENING POINT AND PENETRATION, IT IS SHOWN HOW, WITH THE AID OF THE STATED CURVES AND EMPIRICAL RELATIONSHIPS, TO FIND THE WHOLE RHEOLOGICAL BEHAVIOR OF AN ASPHALT. SEVERAL PROTOTYPE EXAMPLES OF ENGINEERING PROBLEMS ARE SOLVED, AND ARE EVIDENCE THAT ASPHALTS, NO LESS THAN METALS, CAN BE DEALT WITH AS ENGINEERING MATERIALS. A FLOW PROBLEM IS SOLVED WITH THE AID OF THE CURVES OF INITIAL VISCOSITY VERSUS TEMPERATURE. USE OF THE TWO RHEOLOGICAL MODULI IN SOLVING ENGINEERING PROBLEMS IS SHOWN FOR THE CASE OF THE ATTENUATION OF VIBRATIONS. ALSO THE METHOD OF EXTENDING CLASSICAL ELASTIC THEORY TO THESE VISCO-ELASTIC MATERIALS IS OUTLINED, WITH THE PARTICULAR CASE OF A BENDING BEAM GIVEN IN DETAIL. THE PROBLEM OF WHETHER THERMAL CHANGES WILL CAUSE CRACKING OF AN ASPHALT IS INVESTIGATED. /AUTHOR/
Demonstrating carbon capture (2009)

Australia is at the forefront of advancing CCS technology. The CO2CRC's H3 (Post-combustion) and Mulgrave (pre-combustion) capture projects are outlined. The capture technologies for these 2 demonstration projects are described. 1 map., 2 photos.
Signal processing for 15/27-GB read-only disk system (1999)

In order to realize 15/27 GB Read-Only disk system using blue laser, new signal processing is required. We have realized 15/27 GB system by using the 2 dimensional adaptive equalizer. The 2 dimensional equalizer was composed of the cross-talk cancel system, the asymmetry compensation type tangential adaptive equalizer and the limit equalizer. By using these signal-processing systems we could reduce the bottom jitter more than 3 % and we could expand the tilt margin.
Impaired graft survival in pediatric renal transplant recipients with donor-specific antibodies detected by solid-phase assays (2010)

SAB assays have increased the sensitivity and specificity to detect HLA alloantibodies, but there is uncertainty about the clinical relevance of SAB-positive alloantibodies when the FCXM is negative. We performed a retrospective study to evaluate the clinical significance of SAB-detected DSA in 82 pediatric recipients of a first kidney transplant between January 2000 and December 2005 who had a negative pretransplant FCXM. Pretransplant sera were evaluated by SAB for DSA. Graft loss and rejection between patients with (DSA+) and without DSA (DSA-) were compared. DSA were detected in 13.9%. Eighty percent of DSA+ subjects were DD transplant recipients vs. 56.9% in the DSA- cohort. The RR of graft loss in DSA+ vs. DSA- was 3.3 (95% CI, 1.4-7.9) and in DD was 4.3 (95% CI 1.4-13.1). By Cox regression, the HR of graft loss in DSA+ vs. DSA- was 2.8 (95% CI 0.7-10.9; p = 0.14) and in DD was 5.1 (95% CI 1-25.6; p = 0.05). Acute rejection occurred in 60% in the DSA+ vs. 44.4% in DSA- (p = 0.5). SAB-detected DSA was associated with impaired renal allograft survival in pediatric renal transplant recipients. Impaired graft survival in pediatric renal transplant recipients with DSA detected by solid-phase assays.
A general and rapid approach to crystalline metal sulfide nanoparticle synthesis for photocatalytic H<sub>2</sub> generation (2017)

CdS can be rapidly yielded within minutes by capitalizing on a microwave-assisted heating strategy. The CdS produced under optimal conditions (35 min) showed a H<sub>2</sub> generation rate that is comparable to that of commercially available CdS.
Hormonal mechanisms in the onset of puberty (1975)

Summary Sexual maturation is associated with increasing levels of sex steroids. These steroidal events are the result of complex changes that occur at several functional levels including the hypothalamus, pituitary, gonad and adrenal gland. These changes, as outlined in Table 3, are often interrelated. While considerable progress has been made in our understanding of the hormonal events associated with sexual maturation, many important questions remain unanswered. Further intensive investigation will be required before we have a lucid understanding of the physiological basis of the sequence of hormonal events which occur during the pubertal process.
Molecular Recognition by Supramolecular Hosts Composed of an Adamantyl-appended Macrocycle with Cyclodextrins in Water (2003)

Abstract A supramolecular system composed of a cyclophane bearing adamantyl moieties with cyclodextrins was developed. The binding affinities of cyclophane toward fluorescent guests such as TNS were effectively retained even when the host was assembled with α-cyclodextrin in neutral aqueous media. Its binding site was significantly apolar and well shielded from the bulk aqueous phase. The marked motional repression was also observed for the entrapped guest molecules.
The method of V. M. Popov for differential systems with random parameters (1971)

The aim of this paper is to investigate the existence of a random solution and the stochastic absolute stability of the differential systems (1.0)–(1.1) and (1.2)–(1.3) with random parameters. These objectives are accomplished by reducing the differential systems into a stochastic integral equation of the convolution type of the form (1.4) and utilizing a generalized version of V. M. Popov's frequency response method.
Use of green fluorescent protein in visualisation of pneumococcal invasion of broncho-epithelial cells in vivo (2001)

The pneumococcus is the principle cause of bacterial pneumonia and also a major cause of bacterial meningitis. The mechanisms and sites of pneumococcal adherence and invasion of the respiratory tract in vivo are not clear however. We have made pneumococci expressing green fluorescent protein (GFP) and used it to trace pneumococcal adherence and invasion in vivo. By using GFP pneumococci we have shown bacterial adherence and invasion of broncho-epithelial cells in vivo by 4 h post-infection, with increases in pneumococcal invasiveness by 24 h. Using confocal image analysis we have shown varying levels of pneumococcal penetration and internalisation into host cells, as well as translocation through epithelial layers. To our knowledge this is the first report of pneumococcal invasion and cellular translocation in vivo.
Magnetic driving energy of the tearing mode (1979)

The change in the magnetic energy density produced by a tearing mode is calculated exactly. The driving energy for the mode is found to come entirely from the region inside the tearing layer, although there is also a displacement of energy in the outer region which integrates to zero. The total change in magnetic energy is exactly equal to the change in a quadratic form related to a variational principle for the full resistive equations.
A digitally implemented modem - Theory and emulation results (1992)

Theory and hardware emulation results are presented for a very flexible digitally implemented modem whose technology is useful over a broad class of terrestrial and in-flight satellite communications applications. The interdependent detection and tracking loop architectures based on the 'joint estimator-detector' approach is shown to perform well for various modulation techniques. The analysis is accurate in setting the loop parameters, and also predicting their transient behavior.
Comparison of Relativistic Perturbations on Spacecraft Earth Orbits (2013)

In this paper, the individual relativistic perturbations are simulated and compared, for two orbit cases: (1) a medium altitude eccentric earth orbit (MEO), and (2) a Molniya orbit. The results of the simulations are presented in graphical and statistical form. The simulation data reveals that the specific forces that arise from the relativistic perturbations do manifest as variations in the classical orbital elements. It is also apparent from the simulated data that the specific forces exhibit similar effects that materialize from commonly considered perturbations that are used in orbit design and maintenance. ABSTRAK: Dalam kertaskerja ini, pengusikan relativistik disimulasi dan dibandingkan secara individu bagi dua kes orbit: (1) orbit eksentrik bumi ketinggian sederhana (MEO), dan (2) orbit Molniya. Hasil simulasi ini dibentangkan dalam bentuk grafik dan statistik. Data simulasi menunjukkan daya spesifik pengusikan relativistik timbul sebagai variasi bagi elemen orbit klasik. Data simulasi menunjukkan daya spesifik memberi kesan yang sama dengan pengusikan biasa yang digunakan dalam rekabentuk dan penyelenggaraan orbit.KEYWORDS: relatistic perturbations; orbit perturbations
Etanercept treatment in corticosteroid-dependent myasthenia gravis (2004)

The authors report a prospective pilot trial of etanercept in corticosteroid-dependent autoimmune myasthenia gravis. Eleven patients were enrolled, with eight completing the 6-month trial. Two patients were withdrawn owing to disease worsening, and one patient was withdrawn because of an erythematous skin rash. Six of the eight patients who completed the trial improved, based on quantitative measures of muscle strength and lowering of corticosteroid requirement.
Photoluminescence in ZnSe-based quantum well wire structures (1993)

We have fabricated quantum well wire structures by using electron beam lithography and reactive ion etching techniques on (Zn,Cd)Se/Zn(S,Se) multiple quantum well structures. Photoluminescence efficiencies have been studied as a function of the wire width (down to about 400 Å), and temperature. The results indicate that the sidewall surfaces exposed during the dry etching play an important role in providing nonradiative centers for the optically injected carriers, strongly diminishing the radiative efficiencies in the smallest structures.
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes) (2008)

DUBs (deubiquitinating enzymes) are a family of proteases responsible for the specific removal of ubiquitin attached to target proteins and thus control the free cellular pools of this molecule. DUB activity is usually assayed using full-length ubiquitin, and these enzymes generally show low activity towards small substrates that constitute the P4-P1 LRGG (Lys-Arg-Gly-Gly) C-terminal motif of ubiquitin. To gain insight into the C-terminal recognition region of ubiquitin by DUBs, we synthesized positional scanning libraries of fluorigenic tetrapeptides and tested them on three examples of human DUBs [OTU-1 (ovarian tumour 1), Iso-T (isopeptidase T) and UCH-L3 (ubiquitin C-terminal hydrolase L3)] and one viral ubiquitin-specific protease, namely PLpro (papain-like protease) from SARS (severe acute respiratory syndrome) virus. In most cases the results show flexibility in the P4 position, very high specificity for arginine in the P3 position and glycine in the P2 position, in accord with the sequence of the natural substrate, ubiquitin. Surprisingly, screening of the P2 position revealed that UCH-L3, in contrast with all the other tested DUBs, demonstrates substantial tolerance of alanine and valine at P2, and a parallel analysis using the appropriate mutation of the full-length ubiquitin confirms this. We have also used an optimal tetrapeptide substrate, acetyl-Lys-Arg-Gly-Gly-7-amino-4-methylcoumarin, to investigate the activation mechanism of DUBs by ubiquitin and elevated salt concentration. Together, our results reveal the importance of the dual features of (1) substrate specificity and (2) the mechanism of ubiquitin binding in determining deubiquitination by this group of proteases.
Modulation of Ca<sub>V</sub>2.3 Calcium Channel Currents by Eugenol (2008)

Eugenol, a natural congener of capsaicin, is a routine analgesic agent in dentistry. We have recently demonstrated the inhibition of Ca(V)2.2 calcium channel and sodium channel currents to be molecular mechanisms underlying the analgesic effect of eugenol. We hypothesized that Ca(V)2.3 channels are also modulated by eugenol and investigated its mode of action using the whole-cell patch-clamp technique in a heterologous expression system. Eugenol inhibited calcium currents in the E52 cell line, stably expressing the human Ca(V)2.3 calcium channels, where TRPV1 is not endogenously expressed. The extent of current inhibition was not significantly different between naïve E52 cells and TRPV1-expressing E52 cells, suggesting no involvement of TRPV1. In contrast, TRPV1 activation is prerequisite for the inhibition of Ca(V)2.3 calcium channels by capsaicin. The results indicate that eugenol has mechanisms distinct from those of capsaicin for modulating Ca(V)2.3 channels. We suggest that inhibition of Ca(V)2.3 channels by eugenol might contribute to its analgesic effect.
Affinity-Trap Polyacrylamide Gel Electrophoresis: A Novel Method of Capturing Specific Proteins by Electro-Transfer (2009)

A method for the affinity capture of specific proteins from a complex mixture using a polyacrylamide gel technique is described. The approach is based on the orthogonal electro-transfer of proteins separated by ordinary polyacrylamide gel electrophoresis (PAGE) to a ligand-coupled polyacrylamide gel (Li-PAG), which is placed under the PAGE gel. Upon electro-transfer, the proteins orthogonally migrate from the PAGE into the Li-PAG, based on the net charge. During migration to the Li-PAG, proteins that specifically interact with a ligand can be transiently trapped in the Li-PAG, while those that do not interact with a ligand pass through it. This method permits the separation of the proteins that can specifically interact with a ligand, even when present in a complex mixture. The method is demonstrated by applying it to the one-step isolation of a trypsin inhibitor from a crude extract of soybean flour.
The equilibrium position of the reaction of bovine liver glutamate dehydrogenase with pyridoxal 5′-phosphate. A demonstration that covalent modification with this reagent completely abolishes catalytic activity (1975)

1. The activity of bovine liver glutamate dehydrogenase incubated with pyridoxal 5'-phosphate declined to a steady value reached within 30--60 min. The residual activity depended on the concentration of modifier up to about 5 mM. Above this concentration, however, no further inactivation was produced. The minimum activity obtainable in such incubations was 6--7% of the initial value. 2. Km values of the modified enzyme were unaltered, whereas Vmax. was decreased. 3. Activity was fully regained on dialysis against 0.1 M-potassium phosphate buffer. 4. Reduction with borohydride rendered the inactivation permanent but did not alter its extent. 5. Enzyme permanently inactivated in this way to the extent of 90% and dialysed was re-treated with pyridoxal 5'-phosphate. In this second cycle activity declined from 10 to 1% of the original activity. 6. This strongly suggests that the failure to achieve complete inactivation in a single cycle reflects a reversible equilibrium between inactive Schiff base, i.e. covalently modified enzyme, and a non-covalent complex. 7. The re-inactivation reaction occurring on dilution was demonstrated directly and a first-order rate constant obtained (0.048 min-1). This, in conjunction with an estimate of the forward rate constant for Schiff-base formation, obtained by approximate pseudo-first-order analysis of inactivation at varied modifier concentrations, gives a predicted minimum activity very close to that actually obtained in a single cycle of treatment. 8. The dissociation constant of the non-covalent complex is given by two methods as 0.90 and 1.59mM. 9. The results indicate that covalent modification with pyridoxal 5'-phosphate completely abolishes the activity of glutamate dehydrogenase.