gebhart/patrepeval huggingface dataset:
Direct in vivo demonstration by radioautography of specific binding sites for calcitonin in skeletal and renal tissues of the rat. (1980)

An in vivo binding assay using radioautography was employed to visualize calcitonin receptors in rat tissues. At 2 min after intravenous injection of biologically active 125I-salmon calcitonin, free hormone was separated from bound hormone by intracardiac perfusion with lactated Ringer's followed by fixation with 2.5% glutaraldehyde. Various tissues were removed and processed for light and electron microscope radioautography. These were compared to tissues removed from animals that received identical amounts of labeled hormone with a large excess of unlabeled calcitonin. Among the tissues investigated, kidney and bone demonstrated labeling. In kidney, most silver grains were located over vesicles below the brush border of cells of theproximal convoluted tubules. These grains were still present after simultaneous injection of excess unlabeled hormone and most likely represented binding to sites involved with ingestion and degradation of hormone from the urinary filtrate. In contrast, grains localized to the basal surfaces of distal convoluted tubule cells were significantly reduced in number in control animals and represented sites of saturable, specific hormone binding. In bone, specific binding sites were found only at the periphery of osteoclasts. These labeled cells were located at resorption sites examined in tibia, humerus, and alveolar bone. This demonstration of the localization of 124I-calcitonin in situ provides a new approach for study the interaction of calcium-regulating hormones with their target cells.
Morphology and properties of nanocomposites from organoclays with reduced cation exchange capacity (2007)

[Article in J Appl Polym Sci 2007, 105, 2910] In the recently published article cited above, the legends for figures 5 and 9 were incorrect. The correct legends are printed below. Figure 5 TEM micrographs of PP/PP-g-MA/M2(HT)2 nanocomposites with high clay concentrations: (a) M2(HT)2 high CEC reduction, (b) 20A, (c) M2(HT)2 control, (d) M2(HT)2 low CEC reduction, and (e) M2(HT)2 med CEC reduction. Figure 9 TEM micrographs of PA-6/M3(HT)1 nanocomposites with high clay concentrations: (a) M3(HT)1 control, (b) M3(HT)1 low CEC reduction, (c) M3(HT)1 med CEC reduction, (d) M3(HT)1 high CEC reduction, and (e) SPX 1137.
AN AIR-ABRASIVE METHOD FOR THE MICRODISSECTION OF MINERALIZED TISSUES (1964)

A method for the microdissection of mineralized tissues is described, utilizing high speed, gas-impelled abrasive for the sectioning. The method was developed to make possible the preparation of histologically defined samples of such tissues for biochemical and biophysical analysis. Mineralized tissue sections are mounted on a motorized, cross-feed stage and passed below a fixed nozzle delivering the abrasive stream. The operator controls the direction and progress of the microdissection through a stereo microscope. This procedure may be readily adapted to a wide variety of preparatory tasks involved in the study of mineralized tissues.
Tactile Display for 2-D and 3-D Shape Expression Using SMA Micro Actuators (2005)

Tactile display which displays character and graphic information dynamically from computer by making pins array up and down has been developed. Shape Memory Alloy (SMA) micro-coil actuators contract and make the pins up and down when an electrical current is supplied. Magnetic material tube is attached to each pin and a permanent magnet fixes position of the pins up or down. Electrical consumption is low because the current is supplied only when the pins move. A 2-D tactile display which has 100 (10/spl times/10) pins array has been developed and successfully operated. The tactile information were displayed sequentially every 0.3 second and the pins were latched at 0.1 N by magnetic force. The pins are arranged at a pitch of 2.5 mm and move 2 mm up and down individually. In order to present the tactile information accurately, narrower pin pitch of the tactile display is preferable. A module for tactile display with a pin pitch of 1.27 mm has been fabricated and successfully operated. A multi-step magnetic latch has been developed for a 3-D tactile display. By using these mechanisms, large displacement and accurate positioning of the pin for 3-D expression can be realized.
Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: Studies of CDKN2A and other genes of the pRB pathway (1999)

Malignant peripheral nerve sheath tumors (MPNSTs) are frequently associated with the disease neurofibromatosis type 1. Only few recurrent cytogenetic changes have been reported, including rearrangements of the short arm of chromosome 9. By fluorescence in situ hybridization with a centromere 9 probe, and by allelic imbalance studies with seven 9p21–23 markers in nine familial and three sporadic MPNSTs, we found interstitial deletions that supported CDKN2A as a possible target gene. Nine MPNSTs showed aberrations of CDKN2A by Southern blot analyses, and in four of these, expression of CDKN2A could not be detected by Northern blot analysis. No mutations of CDKN2A were identified by sequencing of the coding region, and gene inactivation by promoter methylation was not found. In the 9p allelic imbalance studies, a novel allele was detected at one locus in one tumor. Analyses of additional markers (n = 8) excluded mismatch repair deficiency as an important mechanism in the genesis of these tumors. The tumors were analyzed further for alterations in other candidate cell cycle-associated genes. In total, 11/12 MPNSTs showed DNA changes in one or more of the genes CDKN2A, CDKN2B, RB1, CDK4, MDM2, and CCND2. The present study suggests that disruption of the pRB pathway is common in MPNST, and that dose reduction of CDKN2A is particularly frequent and contributes to MPNST development. Genes Chromosomes Cancer 26:151–160, 1999. © 1999 Wiley-Liss, Inc.
Inhibition of Tumor Growth in Mice by Microwave Hyperthermia, Polyriboinosinic-Polyribocytidylic, and Mouse Interferon (1978)

Mice bearing sarcoma 180 tumors were irradiated by 3000-MHz microwave at a power density of 40 mW/cm/sup 2/ for 2 h daily during 14 consecutive days. The irradiation resulted in an increase of rectal temperature of 3-4/spl deg/C. Hyperthermal treatment was started on the second day after tumor-cell transplantation. Some of the animals also received daily injections of polyhiboinosinic acid-polyribocytidylecacid (poly I-poly C), 2 mu g/g, or of mouse interferon (100 IU/g), or of both. Survival of the animals, mass of the tumors, incorporation of tritiated thymidine, uridime and glycine into the tumor tissue, and intracellular levels of cyclic AMP were determined. Microwave hyperthermia resulted in a prolongation of the survival of tumor-bearing mice, a regression of tumors in 12 out of 24 mice, and a decreased incorporation of thymidine and glycine. The inhibitory effect of microwave hyperthermia was enhanced by simultaneous treatment with poly I-poly C and mouse interferon. Combination of microwave hyperthermia and poly I-poly C and interferon treatment resulted in a regression of sarcoma 180 tumors in 16 out of 24 animals. No tumor regression was observed in the control group.
Immune Responses to Varicella Zoster Virus Infections in Healthy Children (1993)

The immune responses to varicella zoster virus were studied in 67 otherwise normal children participating in a placebo-controlled trial of acyclovir for the treatment of chickenpox. No differences were observed between acyclovir and placebo groups. Children were studied longitudinally, at onset of chickenpox, and at 1 month, 3 months, 1 year, and 3 years after infection. These data help define the natural history of the immune response to chickenpox in children.
Site-selective observation of nuclear Overhauser effects in proteins via isotopic labeling (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSite-selective observation of nuclear Overhauser effects in proteins via isotopic labelingMark Rance, Peter E. Wright, Barbara A. Messerle, and Leslie D. FieldCite this: J. Am. Chem. Soc. 1987, 109, 5, 1591–1593Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/ja00239a062https://doi.org/10.1021/ja00239a062research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PISTON LUBRICATION IN RECIPROCATING COMPRESSORS (2001)

Piston dynamics plays a fundamental role in two critical processes related to fluid flow in reciprocating compressors. The first is the refrigerant leakage through the radial clearance, which may cause considerable loss in the pumping efficiency of the compressor. The second process is the viscous friction associated with the lubricant film in the radial clearance; certainly a significant factor in the compressor energy consumption. In the present contribution a numerical simulation of the piston movement inside the cylinder of a reciprocating compressor is performed. The compressor considered here is a small hermetic compressor employed in domestic refrigerators. For the problem formulation both the axial and the radial piston motion is considered. In operation, the piston moves up and down along the axis of the cylinder, but the radial oscillatory motion in the cylinder bore, despite being usually small, plays a very important role on the compressor performance and reliability. The compromise between sealing of the gas leakage through the piston-cylinder clearance and the friction losses requires a detailed analysis of the oscillatory motion for a good design. The forces acting on the piston are the hydrodynamic force due to the pressure build up in the oil film (lubrication effects), the force due to the connecting rod, the viscous force associated with the relative motion between the piston and oil, and the force exerted by the gas on the top of the piston. All corresponding moments are also included in the problem formulation of the piston dynamics, in order to determine the piston trajectory, velocity and acceleration at each time step. The hydrodynamic force is obtained from the integration of the pressure distribution on the piston skirt, which, in turn, is determined from a finite volume solution of the time dependent equation that governs the oil flow. A Newton-Raphson procedure was employed in solving the equations of the piston dynamics. The results explored the effects of some design parameters and operating conditions on the stability of the piston, its sealing performance and friction losses. Emphasis was placed on investigating the influence of the pin location, radial clearance and oil viscosity on the piston dynamics. The complexity of the piston movement in reciprocating compressors was demonstrated and the detailed model presented can be employed as an useful tool for engineering design.
A T4-Induced Endonuclease Which Attacks T4 DNA (1970)

A DNA endonucleolytic activity that introduces single-stranded breaks into native T4 DNA is found in T4-infected E. coli. This endonuclease attacks other double-stranded, but not single-stranded, DNA. Experiments with ultraviolet-irradiated phages and amber mutants indicate that the enzyme is made beginning about five minutes after infection at 37 degrees C.
Pyrolysis of RP-2 and Surrogate Fuels in a Jet Stirred Reactor Coupled with Synchrotron Photo Ionization Mass Spectrometry (2017)

Combustion chemistry of real fuels are highly complicated by hundreds of individual chemical components that represent their broad composition spectrum. At the same time, typical speciation techniques are limited by the number of individual compounds which can be detected in a single experiment. In this work, the pyrolysis of RP-2 (a kerosene-based rocket fuel) was investigated in a jet stirred reactor (JSR) coupled with synchrotron photo ionization mass spectrometer (PIMS) at various temperatures (295-541 C) and photon energies (7.9-9.7 eV) at atmospheric pressure. The synchrotron PIMS is a powerful tool to identify and characterize various chemical compounds simultaneously. The mass spectrum signals were presented and the products were identified by comparing mass signal intensity versus photon energy and the corresponding standard photoionization efficiency (PIE) spectrum. The product identification showed that peaks at mass-to-charge-ratio (m/z)=54 is 1,3-butadiene (C4H6) and m/z=66 is 1,3-cyclopentadiene (C5H6). The m/z=68 indicated cyclopentene (C5H8) contribution, m/z=78 was matched with benzene (C6H6) PIE, the peak at m/z=92 confirmed toluene (C7H8), and m/z=106 was in perfect match with Xylene (C8H10). In summary, the dominant product peak is benzene followed by toluene and most peaks in the RP-2 product spectrum are aromatic compounds. The present results indicated the potential of JSR and Synchrotron-PIMS as a tool to identify multiple combustion species in a single experiment to study the kinetics of real fuels.
P170 Predictors of renal survival in a cohort of patients with lupus nephritis with more than 30 years of follow-up (2020)

Abstract Background Despite the improvement in survival of patients with lupus nephritis (LN) over the last decades, LN is associated with progression to end-stage renal disease (ESRD) in a significant proportion of patients. We aimed to investigate the factors influencing renal survival in patients with LN. Methods Single-centre retrospective observational study. Patients with biopsy-proven proliferative, membranous or mixed LN were included. Individual clinical files were reviewed to obtain demographic, clinical, laboratory and pathological data. Cox regression analysis was performed to investigate predictors of progression to ESRD and Kaplan-Meier curves were obtained. Results We studied 187 LN patients (135 proliferative, 38 membranous and 14 mixed LN), followed for up to 42 years (mean 13±9 years). Cumulative renal survival rates at 5, 10, 15 and 20 years were 93%, 85%, 78% and 70%, respectively. In univariable analysis, urinary protein/creatinine ratio (uPCR) above 42 mg/mmol or estimated glomerular filtration rate (eGFR) below 76 mL/min/1.73m2, one year after the diagnosis of LN, were the strongest predictors of progression to ESRD, with hazard ratios (HR) of 8.081 [95%CI:1.856-35.179] and 4.985 [95%CI:1.964-12.651], respectively. HR for uPCR and eGFR at the time of diagnosis were considerably smaller (2.508 [95%CI:1.062-5.922] and 2.833 [95%CI:1.156-6.945] respectively). Other factors associated with increased risk of ESRD were Afro-Caribbean ethnicity (HR = 3.861 [95%CI:1.817-8.206]), proliferative LN (HR = 3.423 [95%CI:1.049-11.173]), not having taken antimalarials (HR = 2.180 [95%CI:1.089-4.363]) and poorly controlled diastolic blood pressure (HR = 1.016 [95%CI:1.001-1.030]). The effect of uPCR and eGFR at one year remained significant after adjusting for ethnicity, histological class, uPCR and eGFR at the time of diagnosis, use of antimalarials and diastolic blood pressure (Table 1). Conclusion uPCR above 42 mg/mmol and eGFR below 76 mL/min/1.73m2, one year after the diagnosis of LN, were the strongest predictors of progression to ESRD. Disclosures F. Farinha None. R.J. Pepper None. D.G. Oliveira None. T. McDonnell None. D.A. Isenberg None. A. Rahman None.
The Role of Chain Molecular Weight and Hofmeister Series Ions in Thermal Aggregation of Poly(2-Isopropyl-2-Oxazoline) Grafted Nanoparticles (2018)

Thermoresponsive nanoparticles are promising smart materials for many applications. However, a rational design for applications requires a deeper understanding and experimental verification of the various parameters that influence the thermoresponsiveness of the spherical polymer brushes that define most of such nanomaterials. Therefore, we investigate superparamagnetic iron oxide nanoparticles (SPION) grafted with poly(2-isopropyl-2-oxazoline) (6⁻33 kg mol<sup>-1</sup>) by temperature-cycled dynamic light scattering and differential scanning calorimetry. The grafting of dense spherical polymer brushes leads to lower aggregation temperatures and transition enthalpies when compared with the free polymer. The transition enthalpy and temperature depend on the polymer shell size and structure. The addition of kosmotropic salts decreases the aggregation temperature following the Hofmeister series.
Development and ESCC evaluation of an European optocoupler for space applications (2017)

This paper presents Optoi’s Optocouplers, being developed in the frame of ESA’s European Component Initiative (Phase 2). Their design and main test results are reported, together with the plan of future activities, including the Evaluation Test Plan and radiation tests.
ChemInform Abstract: Aromatic Chloride to Nitrile Transformation: Medicinal and Synthetic Chemistry (2011)

Abstract Review: 79 refs.
Emerging Technologies for Decentralized Production of PET Tracers (2012)

The need to measure and elucidate biological processes in a non-invasive manner in functioning organisms has led researchers to develop more than 1,600 PET probes for metabolism, protein synthesis, receptors, enzymes, DNA replication, gene expression, antibodies, hormones, and therapeutics (Iwata 2004). However, the overwhelming majority of PET for the care of patients utilizes only a single molecular imaging probe, the 18 F-labeled www.intechopen.com
Impact of path loss and delay spread on base station cooperation (2011)

Abstract—In this paper, we investigate the maximum inter-site distance (ISD) for performing joint signal processing between cooperative base stations. As a metric, we use the maximum excess delay measured at 95 % point of the cumative power delay profile from all base stations. For the distance-dependent channel parameters, we consider Greenstein’s statistical propagation model, which we extended for broadband transmissions. We ex-tract all model parameters from 2.6 GHz multi-cell measurements in our field trial and parametrize the model at a fixed ISD. We also investigate the impact of antenna downtilt and find that when a larger downtilt is used, the rms delay spread and 95% excess delay are smaller. However, there are critical 3D effects close to the sites not included in the model. Then we consider larger ISDs and indicate how the delay parameters grow. Based on Greensteins model, the short cyclic prefix in LTE is hardly violated for realistic ISD at 2.6 GHz. I.
Production of IgG autoantibodies to TCRs in mice infected with the retrovirus LP-BM5 (1995)

Autoantibodies (AAbs) directed against particular segments of the variable region of TCR beta chains occur in normal humans and in certain autoimmune diseases, but the factors regulating the appearance of such antibodies are unknown. We report that AAbs binding a peptide determinant corresponding to the CDR1 of the V beta domain are elevated in C57BL/6 mice following infection with the LP-BM5 murine leukemia retrovirus mixture, a treatment used to induce murine AIDS. The elevation of the level of these AAbs is an early event following retroviral infection which corresponds in part to the general polyclonal activation of the B cells, but a selectivity for particular V beta sequences is apparent later. This suggests that the appearance of these antibodies may play a part in the subsequent development of immunodeficiency. Since the antibodies studied are of the IgG isotype, both T cells and B cells are involved in their elaboration.
A 350MHz low-OSR ΔΣ current-steering DAC with active termination in 0.13μm CMOS (2005)

A time-interleaved architecture overcomes the dynamic performance limitations of standard DWA switching. Clocked at 350MHz, the DAC with active output buffer achieves a linearity of 76dB for a signal swing of 1.536V and an effective resolution of 11.9b in a bandwidth of 29.16MHz. It is fabricated in a standard 0.13 /spl mu/m CMOS process and consumes 62mW from a 1.5V supply.
Traumatic Innominate Artery Pseudoaneurysm in the Setting of a Bovine Arch (2011)

Blunt traumatic injury of the innominate artery occurs infrequently but is commonly lethal. Bovine aortic arch anatomy is a predisposition to this injury. Clinical findings, chest X-ray, and computerized tomography may suggest the diagnosis, and it may be confirmed with angiography. Both interposition and bypass grafting are operative repair methods of choice. EEG monitoring confirms cerebral perfusion, thereby allowing the deferment of shunts and cardiovascular bypass with hypothermic arrest. We report a case of traumatic innominate artery pseudoaneurysm in the setting of "bovine aortic arch" anatomy, together with multiple associated injuries, including descending aorta transection. We also review the current literature on the topic.
Stereoselective binding of optically active amino acids by nickel(II) and copper(II) complexes of N-carboxymethyl-.beta.-(2-pyridyl)-L-.alpha.-alanine (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective binding of optically active amino acids by nickel(II) and copper(II) complexes of N-carboxymethyl-.beta.-(2-pyridyl)-L-.alpha.-alanineStephen A. Bedell, Pio R. Rechani, Robert J. Angelici, and Robert. NakonCite this: Inorg. Chem. 1977, 16, 4, 972–973Publication Date (Print):April 1, 1977Publication History Published online1 May 2002Published inissue 1 April 1977https://pubs.acs.org/doi/10.1021/ic50170a060https://doi.org/10.1021/ic50170a060research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts