gebhart/patrepeval huggingface dataset:
A high-speed network for cardiac image review. (1994)

A high-speed fiber-based network for the transmission and display of digitized full-motion cardiac images has been developed. Based on Asynchronous Transfer Mode (ATM), the network is scaleable, meaning that the same software and hardware is used for a small local area network or for a large multi-institutional network. The system can handle uncompressed digital angiographic images, considered to be at the "high-end" of the bandwidth requirements. Along with the networking, a general-purpose multi-modality review station has been implemented without specialized hardware. This station can store a full injection sequence in "loop RAM" in a 512 x 512 format, then interpolate to 1024 x 1024 while displaying at 30 frames per second. The network and review stations connect to a central file server that uses a virtual file system to make a large high-speed RAID storage disk and associated off-line storage tapes and cartridges all appear as a single large file system to the software. In addition to supporting archival storage and review, the system can also digitize live video using high-speed Direct Memory Access (DMA) from the frame grabber to present uncompressed data to the network. Fully functional prototypes have provided the proof of concept, with full deployment in the institution planned as the next stage.
Particle Swarm Optimization Based on Genetic Operators for Sensor-Weapon-Target Assignment (2012)

In the modern battlefields based on network, guided weapons highly rely on the sensors, so the benefit of assigning a given weapon to a target often depends on the pre-assigned sensor. in order to solve sensor-weapon-target (SWT) assignment which is an important activity involved in planning and executing a course of battle action, a model of SWT problem is established firstly. Secondly, particle swarm optimization based on genetic operators is put forward to solve the model, in which the restriction of problems is transformed by coding solutions, according to optimal solutions of population and individual, the new particle is updated by crossover, mutation and selection operators. Finally, after the numerical experiment of the algorithm, it is proved to be feasible and effective, especially in solving large-scale problems, it shows much better performance.
Radiofrequency Plasma Thrusters: Modelling Of Ion Cyclotron Resonance Heating And System Performance (2007)

Recent advances in plasma-based propulsion systems have led to the development of electromagnetic (RF) generation and acceleration systems, capable of providing highly controllable and wide-ranging exhaust velocities, and potentially enabling a wide range of missions from KWs to MWs levels. In this paper we report on the development of a system-level modelling of a three-stage helicon plasma thruster composed of a helicon plasma source, a confining magnetic field structure enclosing a plasma heating section, and a magnetic nozzle. This modelling can help to optimize the design parameters (antenna shape, matching circuits and generators, and the ensuing evaluation of the required power, mass and other physical parameters, including magnetic field for confinement), and estimate the system feasibility: in particular our activity focuses on the most critical RF issues and on the RF-plasma interactions. We have divided the study into two different and linked parts: 1) RF system modelling, which provides an interface between the RF power generation and the power deposition into the plasma and relies on the TOPICA code, and 2) plasma device modelling of the sub-systems and of their connection, which yields the global, system-level description of the engine.
Current Status and Future Directions of the Immune Checkpoint Inhibitors Ipilimumab, Pembrolizumab, and Nivolumab in Oncology (2015)

The treatment landscape in oncology is quickly evolving with the advent of ICIs.
Systèmes intégrables à $m$-corps sur la droite (1991)

Analyse globale et Physique mathmatique M ddi la mmoire d'Edmond Combet.
Anonymous attribute certificates based on traceable signatures (2006)

Purpose To provide a cryptographic protocol for anonymously accessing services offered on the web. Such anonymous accesses can be disclosed or traced under certain conditions. Design/methodology/approach The “traceable signature” scheme was used in conjunction with the “privilege management infrastructure”. Findings The cryptographic primitive provides a suitable tool for anonymous and unlinkable access to web resources based on the privileges that users hold. Moreover, the scheme allows for anonymity revocation and tracing of unlinkable accesses. Research limitations/implications The power of the attribute authority should be divided into several entities, one of them being a trusted third party, to avoid illicit disclosing of information. Practical implications New systems with support for anonymous access to web resources can be developed. Originality/value This paper adds the unlinkability property to anonymous accesses together with a tracing facility to existing proposals.
El temor a Yahweh en los profetas (1992)

EN ESTE TRABAJO SE HA INTENTADO ALCANZAR EL SENTIDO DEL TEMOR, PARA LO CUAL HEMOS RECOPILADO CON LA AYUDA DE DISTINTAS CONCORDANCIAS, TODOS LOS TEXTOS DE LOS PROFETAS EN LOS QUE APARECIERA EL BAJO CUALQUIERA DE SUS SIGNIFICADOS, CON LO QUE HEMOS AGOTADO, PRACTICAMENTE, TODO EL CAMPO SEMANTICO DEL TEMOR. EN EL CAPITULO I SE TRATAN LOS TERMINOS DISTINTOS DE YR; EN EL CAPITULO II SE ANALIZAN LOS DIVERSOS CONTENIDOS DE LA RAIZ YR; Y EN EL CAPITULO III SE ESTUDIA EL ALCANCE DE LA FORMULA 1-TYR. PRETENDEMOS DEMOSTRAR QUE EL VERBO YR TIENE UN CONTENIDO EMINENTEMENTE RELIGIOSO, MIENTRAS QUE LOS DEMAS VERBOS LO TIENEN EMINENTEMENTE PROFANO, CON LO QUE EL CONCEPTO DE TEMOR DE DIOS RESULTA DISTINTO DE LOS OTROS SENTIMIENTOS DE QUE SE MANIFIESTAN EN EL HOMBRE. EL TEMOR DE DIOS VIENE A RESUMIR LA ACTITUD -PIEDAD, CULTO, COLABORACION, SOMETIMIENTO, AMOR, ESPERANZA, ETC.- DEL FIEL ISRAELITA HACIA DIOS.
Spirometric Studies in Normal Subjects<sup>1</sup><i>IV. Ventilatory Capacities in Healthy Children 7–17 Years of Age</i> (1963)

SUMMARY Vital capacity (VC), forced expiratory volume in 1 sec (FEV 1.0 ) and maximum voluntary ventilation (MTV) at free and fixed frequencies have been determined in normal children, 79 boys and 82 girls, 7–17 years of age. These values were found best correlated with the cube of the height. Equations and nomograms for normal values and lower normal limits are given.
Access Types Effect on Internet Video Services and Its Implications on CDN Caching (2017)

Video providers heavily rely on geographically distributed content distribution networks (CDNs) to place video content as close to users as possible, with an aim of improving video quality and avoiding single point of failure at the server side. The effectiveness of CDNs is mostly dependent on the content consumption patterns. Currently, video providers are offering access to content from different platforms (e.g., mobile devices and PC clients), which might result in distinct video content consumption patterns and finally affect the efficiency of CDN caching. Nevertheless, the access type effect on Internet videos is not well understood. In this paper, using a data set consisting of 26 million video requests of a large-scale commercial video-on-demand system, we study the effect of three main access types, i.e., proprietary software on PC clients, Web browser, and mobile apps. Several observations suggest that access types should be considered carefully in CDN design. In particular, the user engagement, user interests in content, and video popularity dynamics patterns, three important factors for video caching, vary remarkably in the three access types. Leveraging off our findings, we propose an access type-aware CDN caching system that associates a cache for each access type and also several optimizations, including partial caching of videos based on chunk-level caching, cross-platform read-only cache access, and prefiltering of the least popular videos. Trace-driven simulations demonstrate that the access type-aware CDN caching achieves high cache hit rate and, more importantly, greatly reduces the disk load that is measured by the number of cache replacement operations.
THE PRODUCTION OF Na<sup>22</sup> BY A (H<sup>3</sup>, <i>n</i>) REACTION IN A NUCLEAR REACTOR (1954)

The positron emitting Na 22 of 2.6 year half-life has been prepared in a nuclear reactor by the double reaction Li 6 (n, α)H 3 , Ne 20 (H 3 , n)Na 22 . The over-all yield was 2.3 × 10 −7 atoms of Na 22 per atom of tritium formed. Eleven grams of lithium as aluminum alloy turnings in a neon atmosphere at 200 p.s.i. was irradiated for 175 days in a neutron flux of about 4 × 10 12 n./cm. 2 /sec. About 380 μc. of Na 22 was obtained in a sodium extract having a specific activity of 10 mc. Na 22 /gm. of Na 23 . A specific activity in the curie/gm. level would be expected from a longer irradiation in the highest flux (6 × 10 13 n./cm. 2 /sec.) in the NRX reactor. The separation and purification of the sodium proved practicable by paper chromatography or ion exchange; the analyses for trace Li and Na 23 were carried out by radioactivation.
Hydrogen Permeability of Polymer Matrix Composites at Cryogenic Temperatures (2005)

This paper presents experimental methods and results of an ongoing study of the correlation between damage state and hydrogen gas permeability of laminated composite materials under mechanical strains and thermal loads. A specimen made from IM-7/977-2 composite material has been mechanically cycled at room temperature to induce microcrack damage. Crack density and tensile modulus were observed as functions of number of cycles. Damage development was found to occur most quickly in the off-axis plies near the outside of the laminate. Permeability measurements were made after 170,000 cycles and 430,000 cycles. Leak rate was found to depend on applied mechanical strain, crack density, and test temperature.
The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients (2006)

Cyclosporin and tacrolimus remain the cornerstone immunosuppressive drugs in organ transplantation. Dosing and monitoring these drugs is based on pharmacokinetic protocols, but measuring a pharmacodynamic parameter, calcineurin phosphatase (CaN) activity, could be a valuable supplement in determining optimal doses. Forty stable renal transplant patients were investigated three times in a 6-month period. Blood samples were drawn at 0, 1, 2, 3 and 4 h after oral intake of tacrolimus (FK) or cyclosporin at days 1 and 180. At day 90, one blood sample at trough level (FK) or C2 level (cyclosporin A, CsA) was drawn. CaN activity was determined in whole blood as the release of 32P from a phosphorylated peptide. Activity of the 32P was quantitated by liquid scintillation and results converted to Units CaN, utilizing a calibration curve with CaN. We demonstrated that calcineurin activity profiles at days 1 and 180 were the same for both drugs. Furthermore, we found that patients treated with tacrolimus or cyclosporin displayed different calcineurin activity profiles. We found that cyclosporin displayed greater calcineurin inhibition than tacrolimus. We have demonstrated that the two drugs exert significantly different effects on calcineurin activity in renal transplant patients with stable, well-functioning grafts and that tacrolimus-treated patients can maintain good, stable graft function with minimal CaN inhibition.
A comparative analysis of Cross Site Scripting (XSS) detecting and defensive techniques (2017)

Now the web applications are highly useful and powerful for usage in most fields such as finance, e-commerce, healthcare and more, so it must be well secured. The web applications may contain vulnerabilities, which are exploited by attackers to steal the user's credential. The Cross Site Scripting (XSS) attack is a critical vulnerability that affects on the web applications security. XSS attack is an injection of malicious script code into the web application by the attacker in the client-side within user's browser or in the server-side within the database, this malicious script is written in JavaScript code and injected within untrusted input data on the web application. This study discusses the XSS attack, its taxonomy, and its incidence. In addition, the paper presents the XSS mechanisms used to detect and prevent the XSS attacks.
GROSS CONGENITAL MALFORMATIONS IN SIBLINGS OF CHILDREN WITH GLUCOSE‐6‐PHOSPHATE DEHYDROGENASE‐DEFICIENT ERYTHROCYTES (1964)

Summary Gross skeletal and other malformations occurred in three older male siblings of two unrelated males with glucose‐6‐phosphate dehydrogenase‐deficient erythrocytes. A history of maternal ingestion of promazine hydrochloride was obtained in one relevant pregnancy, of phenolphthalein in another, and of phenacetin, acetylsalicylic acid and extract of the pods of senna in the third. The possible significance of these observations is discussed.
Plasma Transglutaminase in Hypertrophic Chondrocytes: Expression and Cell-specific Intracellular Activation Produce Cell Death and Externalization (1998)

We previously used subtractive hybridization to isolate cDNAs for genes upregulated in chick hypertrophic chondrocytes (Nurminskaya, M. , and T.F. Linsenmayer. 1996. Dev. Dyn. 206:260-271). Certain of these showed homology with the "A" subunit of human plasma transglutaminase (factor XIIIA), a member of a family of enzymes that cross-link a variety of intracellular and matrix molecules. We now have isolated a full-length cDNA for this molecule, and confirmed that it is avian factor XIIIA. Northern and enzymatic analyses confirm that the molecule is upregulated in hypertrophic chondrocytes (as much as eightfold). The enzymatic analyses also show that appreciable transglutaminase activity in the hypertrophic zone becomes externalized into the extracellular matrix. This externalization most likely is effected by cell death and subsequent lysis-effected by the transglutaminase itself. When hypertrophic chondrocytes are transfected with a cDNA construct encoding the zymogen of factor XIIIA, the cells convert the translated protein to a lower molecular weight form, and they initiate cell death, become permeable to macromolecules and eventually undergo lysis. Non-hypertrophic cells transfected with the same construct do not show these degenerative changes. These results suggest that hypertrophic chondrocytes have a novel, tissue-specific cascade of mechanisms that upregulate the synthesis of plasma transglutaminase and activate its zymogen. This produces autocatalytic cell death, externalization of the enzyme, and presumably cross-linking of components within the hypertrophic matrix. These changes may in turn regulate the removal and/or calcification of this hypertrophic matrix, which are its ultimate fates.
Intelligent Decision Making and Optimization of Artificial Lifting Based on MR Multi-Phase Flow Detection (2022)

Abstract Quantitative information regarding multi-phase flow of oil, gas and water in wells or pipelines are very important in guiding the artificial lifting parameters optimization and tool selection. At present, there is no reliable technology available which can accurately measure split flow of multi-phase fluids without separating oil, gas and water. So far, the multi-phase flow measurement technique commonly adopted globally is to carry out by phase separation after produced fluid entering the gathering station through the pipelines, where the content of each component is measured separately. The indirect measurement methods are usually with low-efficiency, high-cost and delay-delivery, and hard to reflect the real instantaneous fluid producing properties at wellheads or pipelines. Therefore, it is urgent to seek for accurate and reliable multi-phase flow detection devices and methods that can meet the monitoring demands for oil and gas resources. This paper proposed a nuclear magnetic resonance (NMR) device and analytical methods for detecting multi-phase fluid. At the same time, it puts forward the intelligent decision-making and optimization technology based on measurement, cloud computing and automatic control. As a green, efficient and accurate method for oil and gas detection, the NMR can realize online measurement for each component of multi-phase flow. Then based on the internet and large data analysis technology to achieve artificial lifting parameters optimization, while based on automatic control technology to achieve artificial lifting equipment negative feedback control. This progress helps to apply the NMR technique in petroleum industry to achieve green, efficient, real-time and low-cost multi-phase flow measurement. Combined with large data, Internet of Things (IOT) and automatic control technology to achieve intelligent artificial lifting technology and system.
Processing algorithms for color flow Doppler (2003)

An examination is made of the design decisions made for five color-flow Doppler units: Acuson, ATL, Hewlett Packard
One-Way GPS Time Transfer 2000 (2000)

On 1 May 2000, the White House issued a Presidential directive for the Global Positioning System (GPS) to turn off Selective Availability (SA) on 2 May 2000. For nearly a decade, authorized user performance of one-way synchronization via GPS has improved every single year. This paper provides an annual assessment of how well the Global Positioning System can predict and disseminate UTC (USNO) to these specified users, based on data generated and processed by the United States Naval Observatory (USNO). And, because the recent Presidential directive now permits civilian timing users to exploit nearly the same, impressive time transfer accuracy of GPS, these annual metrics now offer a fairly representative performance assessment for both military and civilian timing users.
Isolating human antibody against human hepatocellular carcinoma by guided-selection (2005)

Through guided-selection, we got the available human Fab antibodies for the subsequent research. These results suggest that guided selection is a promising strategy in murine mAb humanization.
Functional domains of SPATULA, a bHLH transcription factor involved in carpel and fruit development in Arabidopsis (2008)

The SPATULA (SPT) gene is involved in generating the septum, style and stigma: specialized tissues that arise from carpel margins. By matching sequences within the extended bHLH region of AtSPT across species databases, twelve orthologues were identified in eudicots, rice and a gymnosperm. Two conserved structural domains were revealed in addition to the bHLH region: an amphipathic helix and an acidic domain. These are conserved in the tomato orthologue, which can restore carpel function to spt mutants of Arabidopsis. The acidic domain is essential for SPT carpel function, and the amphipathic helix supports it. A bipartite sequence overlapping the bHLH domain is required for nuclear localization, and a mutation in the conserved beta strand adjacent to the bHLH C terminus results in the loss of SPT function. SPT apparently acts as a transcriptional activator, as the addition of the SRDX repression domain phenocopies the spt mutant phenotype. Expression of an artificially activating 35S:SPT-VP16 construct can induce carpelloid properties in sepals, and new defects in the gynoecium. These disruptions are associated with ectopic expression of the STYLISH2 gene, although STYLISH2 expression does not require SPT function. Ectopic expression of unmodified SPT does not induce such changes, implying that SPT acts in association with essential coactivators present only in regions where SPT is normally active. Because the VP16 activation domain can compensate to some extent for the loss of the amphipathic helix and acidic domain, these domains may normally interact with such co-activators.
A Customized Next-Generation Sequencing-Based Panel to Identify Novel Genetic Variants in Dementing Disorders: A Pilot Study (2020)

Notwithstanding the preliminary value of this study, some rare genetic variants with a probable disease association were detected. Although future application of NGS-based sensors and further replication of these experimental data are needed, this approach seems to offer promising translational perspectives in the diagnosis and management of a wide range of neurodegenerative disorders.
Conductivity and dielectric permittivity of dermis and epidermis in nutrient liquid saturation (1992)

Dielectric permitivity and conductivity of dermis and epidermis in nutrient liquid saturation were measured in the frequency range 1Hz to 100kHz. The results show no differences in the parallel plane to the skin surface and a significant one in the transversal direction.
Simultaneous and orthogonally interactive clock recovery and D.C. null equalization in high density digital magnetic recording (1983)

A detection system for saturation digital magnetic recording is described and analyzed which consists of two simultaneously operating feedback loops whose error signals are interactive, but orthogonal to one another so that stability is readily achieved. The technique involves the generation of two error signals, namely (1) phase, and (2) D.C. offset. Thus, both the horizontal (time) and vertical (offset) errors in the system's decision thresholds are theoretically forced to zero in steady state since both feedback loops are third order. Thus, the entire magnetic "read"/"write" channel is fully equalized including the DC null. In the more conventional "read"/"write" channels, the "read" detection process occurs before and is independent of the subsequent clock recovery process resulting in a significant sacrifice in theoretically achievable overall performance.
The Conserved Serine-Tyrosine Dipeptide in Leishmania donovani Hypoxanthine-guanine Phosphoribosyltransferase Is Essential for Catalytic Activity (1997)

Crystal structures of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) proteins have implied that the translocation of a flexible loop containing a highly conserved Ser-Tyr dipeptide is necessary for the protection of the proposed oxocarbonium ion transition state of the enzyme (Eads, J. C., Scapin, G. T., Xu, Y., Grubmeyer. C., and Sacchettini, J. C. (1994) Cell 78, 325-334; Schumacher, M. A., Carter, D., Roos, D. S., Ullman, B., and Brennan, R. G. (1996) Nature Struct. Biol. 3, 881-887). An essential role for this Ser-Tyr dyad in HGPRT catalysis has now been verified biochemically and genetically for the Leishmania donovani HGPRT employing a combination of protein modifying reagents and site-directed mutagenesis. Incubation of HGPRT with either tetranitromethane or diethyl pyrocarbonate inactivated the enzyme completely, and peptide sequence analysis revealed that tetranitromethane treatment modified the Tyr residue within the Ser95-Tyr96 dipeptide. Analysis of site-directed mutants confirmed that both amino acids were vital for phosphoribosylation activity. Mutant HGPRTs, S95A, S95E, Y96F, and Y96V, exhibited dramatic reductions in their catalytic capabilities of 2-3 orders of magnitude, whereas HGPRTs containing conservative substitutions, S95C and S95T, displayed only a 2-3-fold decrease in kcat. Km values for the substrates of the forward and reverse reactions were largely unchanged for all HGPRT constructs, except for a 4-5-fold decrease in the Km value of the Y96F and Y96V mutants for phosphoribosylpyrophosphate. Expression of L. donovani hgprt constructs in Escherichia coli indicated that wild type and S95T HGPRTs complemented bacterial phosphoribosyltransferase deficiencies, whereas the S95A and S95C mutants complemented weakly, and the S95E, Y96F, and Y96V HGPRT did not support bacterial growth. These data authenticate that the Ser-Tyr dipeptide that is conserved among all members of the HGPRT family is essential for phosphoribosylation of purine nucleobases by HGPRT.