gebhart/patrepeval huggingface dataset:
Poly(triphenylamine) related copolymer noncovalently coated MWCNT nanohybrid: fabrication and observation of enhanced photoconductivity (2006)

Coating multiwall carbon nanotubes (MWCNTs) with a fluorescent poly(triphenylamine) related copolymer (referred to as PTPA), which has both hole-transportation moiety of triphenylamine and conjugated aromatic units of 4,4'-biphenylene vinylene in the chain backbone, can be realized via a facile phase separation strategy. The morphology of the nanohybrids was demonstrated by transmission electron microscopy and the aggregate structure of the copolymer on the MWCNTs was investigated by x-ray diffraction. The weight ratio of the PTPA to MWCNT in the nanohybrids was studied by thermogravimetric analysis. The UV–vis and fluorescence spectra indicated electron interaction between the PTPA and MWCNTs. The enhancement of the photosensitivity of PTPA was also observed. These copolymer-coated MWCNT nanohybrids might then act as a fluorescent probe or a single-layer photoreceptor.
Immunomodulators (2001)

Cytokine immunomodulators have received considerable attention. Interferon-alpha has broad clinical application for treatment of a number of viruses. The neutrophil-stimulatory effects of interferon-gamma are useful in neutrophil disorders. TNF antagonists are useful in rheumatoid arthritis but carry the risk of activating intracellular organisms. Hemopoietic growth factors have considerable clinical effect in patients receiving immunosuppressive chemotherapy. A number of cytokines and cytokine antagonists are undergoing research development.
Thimerosal causes calcium oscillations and sensitizes calcium‐induced calcium release in unfertilized hamster eggs (1991)

Calcium-induced-calcium-release (CICR) was assayed in unfertilized golden hamster eggs by injecting Ca2+ and monitoring Ca2(+)-dependent hyperpolarizing responses (HRs) and Ca2(+)-sensitive fluo-3 fluorescence. Incubating eggs in the sulfhydryl reagent thimerosal caused [Ca2+]i oscillations as monitored by Ca2(+)-dependent HRs and decreased approximately 10-fold the Ca2+ injection current required to generate an HR and cause a large intracellular Ca2+ increase. Thimerosal also enhanced the sensitivity of eggs to Ca2+ injection in a calcium-free medium. The effects of thimerosal on CICR were prevented by dithiothreitol and were not mimicked by injecting inositol 1,4,5-trisphosphate. The data suggest that thimerosal may be an alternative agent for studying CICR in caffeine-insensitive cells.
Optimization of Culture Conditions for Enhanced Butanol Production by a High Butanol Tolerant Clostridium Beijerinckii F-6 (2019)

Developing microorganisms with high butanol tolerant and high production is the prerequisite for biobutanol production. In this study, a strain Clostridium Beijerinckii F-6 was evaluated for the resistance of butanol and it showed excellent butanol tolerance with the ability to grow in 2.5% (w/v) butanol. In order to enhance the performance of butanol production, various parameters affecting on butanol fermentation were optimized using statistical experimental design and analysis. Plackett-Burman design was first used to screen the most important variables influencing butanol production, and subsequently central composite design was adopted to investigate the optimum value of the selected factors for achieving maximum butanol production. Results showed that initial pH, temperature, and exogenous butyrate had signiﬁcant inﬂuence on butanol production and the maximum butanol production and productivity of 7.88g/L and 0.244g/L/h were obtained at initial pH 7.0, 37.1 ℃, and addition of butyrate 1.23g/L. The results indicate that butanol tolerant strain F-6 possessed excellent butanol production performance.
Comparison of FH-MA communications using OFDM and DS-MA systems for wideband radio access (2002)

This paper investigates on the combination of OFDM with SFH as possible solution for a wideband radio multiple-access system. The OFDM component, with noncoherent DPSK demodulation, combats the multipath interference which may severely limit the system performance at high data rates, whereas the SHF portion provides multiaccess capability. The proposed system takes advantage of all the inherent benefits of the FH access, namely: the "near far" resistance and the possibility to employ side information for error and erasure decoding. The system has been compared with pure DS that, in its turn, exploits inherent predetection diversity. The obtained results show that, with appropriate channel coding, OFDM/FH can be considered a viable access scheme for high data rate applications. It is also shown that the proposed system can definitely outperform DS, provided that the OFDM component's efficiency be properly optimized.
A Survey of User-centric Identity Management Technologies (2007)

Computing anytime anywhere is more and more the rule. In this ambient intelligent world, the choice of identity mechanisms will have a large impact on its social, cultural, business and political aspects. Privacy is a human need and the whole of society would suffer from its demise. Moreover, people have a hectic life and cannot spend their time administering their digital identities. In this paper, we survey how the requirements for identity management have evolved, and their associated technologies, with emphasis on the federated approaches and user-centricity.
Studies on the Amine Exchange Reactions in C-Mannich Bases (1982)

<em>Manuscript received 1 December 1980, revised 6 August 1981, accepted 7 January 1982</em> Amine exchange reactions are extended to C-Mannich bases derived from 6-methoxy-1-tetralooe and tbe reaction intermediate during exchange reaction was isolated and characterised.
Adjunctive thrombectomy with primary percutaneous coronary intervention for ST-elevation myocardial infarction: summary of randomized trials. (2006)

Primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) achieves brisk coronary flow in > 90% of patients, but myocardial reperfusion (reperfusion at the tissue level) is often suboptimal, as evidenced by persistent ST-segment elevation and abnormal myocardial blush. Patients with suboptimal myocardial reperfusion have limited myocardial salvage and increased mortality. Distal micro-embolization may contribute to poor myocardial reperfusion, and this has stimulated great interest in the use of adjunctive thrombectomy with primary PCI in an attempt to prevent distal micro-embolization and improve outcomes. In this paper, we review the randomized trials that have evaluated the use of adjunctive thrombectomy with primary PCI using three types of devices (X-sizer, aspiration thrombectomy and rheolytic thrombectomy). The results of these trials have been conflicting and the totality of evidence does not support the routine use of thrombectomy for removal of thrombus in patients with STEMI treated with primary PCI. In patients with large thrombus burden, distal macroembolization is common and is associated with poor outcomes. Adjunctive thrombectomy can effectively remove thrombus, and it seems appropriate to perform adjunctive thrombectomy prior to primary PCI in patients with large thrombus burden.
Determination of tryptophan in urine of autistic and healthy children by gas chromatography/mass spectrometry. (2010)

This method is precise and sensitive for the detection of low concentrations of tryptophan and can be applicable to monitoring its level in human urine. Children with autism have a higher deficiency of tryptophan than the control group of healthy children. Lower levels of tryptophan may lead to the worsening of autistic symptoms such as mild depression and increased irritability.
Automatic RF leakage signal canceler in MRI applications (2017)

This work presents the feasibility demonstration of an automatic RF leakage canceler for magnetic resonance imaging (MRI) applications that require a simultaneous transmit and receive (STAR) system. The automatic system with wireless control enables a radiofrequency (RF) coil to achieve greater than 40 dB decoupling between transmit and receive ports in 900 ms. The system stability and noise contribution to MR images were evaluated. To demonstrate feasibility of this approach, MR images were acquired by transmitting an RF excitation pulse and acquiring an MR receive signal simultaneously on a 4-tesla (T) MRI scanner.
Progress Towards Liver and Lung-Directed Gene Therapy with Helper- Dependent Adenoviral Vectors (2009)

Helper-dependent adenoviral vectors (HDAd) have several characteristics making them very attractive for human gene therapy. These vectors are completely devoid of viral coding sequences and are able to mediate high efficiency transduction in vivo to direct high level transgene expression with negligible chronic toxicity. Progress towards liver and lung directed gene therapy with HDAd as well as the current obstacles facing human applications and possible strategies to overcome these obstacles are discussed.
lithium doping of polycrystalline silicon (1980)

Electrolytic lithium doping of high-purity polycrystalline silicon samples has been shown to increase not only the material conductivity but also the minority-carrier lifetime.
Practical Wisdom, Understanding of Coherence and Competencies for Everyday Life (2009)

Fokus for artiklen er hjemkundsundervisning og dannelse i den danske folkeskole i det 21.århundrede. Praktisk klogskab, forståelse af sammenhæng og hverdagslivskompetence foreslås som mål for hjemkundskabsundervisning og -dannelse. Der argumenteres for at disse elementer skal inkluderes som del af dannelsen i undervisningen i hjemkundskabundervisningen i det senmoderne samfund. Artiklen rejser spørgsmål om hvad, hvordan og hvorfor disse elementer skal indtænkes. Artiklen bygger på litteraturstudier og udviklingsarbejde og aktionsforskning i 2 hjemkundskabsklasser på 2 skoler over 2 år. Det første år med observationer og interviews, fulgt af et år med en aktionsforskningstilgang, hvor der blev afprøvet nye tilgange og ændret indhold i forhold til de problemfelter der kunne rejses efter observationsstudierne og interviewene. Arbejdet blev efterfølgende brugt til udvikling af lærebøger for hjemkundskab i folkeskolen med titlerne: <em>Hjemkundskab i ord og handling og Hjemkundskab i tanke, ord og handling</em>. Denne artikel forsøger at bidrage med et nyt paradigme baseret på kritisk pædagogik, hvilket for hjemkundskabsundervisningen indebærer at vide, kunne, ville og være. Artiklen er et skandinavisk bidrag til et perspektiv på hjemkundskab med formålet at kvalificere den globale forståelse af fagområdet og med en forståelse af forskellige former for kundskab og for opfattelse af professionen. <br/> <a name="_ftn1"/>[1] Bildung is the German word for education, but it is used as a pedagogical term in English literature as it has another and more specific meaning than the word education. The word in Danish is dannelse.
An unusual intermediate filament subunit from the cytoskeletal biopolymer released extracellularly into seawater by the primitive hagfish <i>(Eptatretus stouti)</i> (1994)

Each slime gland thread cell from the primitive Pacific hagfish (Eptatretus stouti) contains a massive, conical, intermediate filament (IF)-rich biopolymer ('thread,' approximately 60 cm length, approximately 3 microns width). In view of the unusual ultrastructure of the thread, its extracellular role in modulation of the viscoelastic properties of mucus, and the ancient lineage of this primitive vertebrate, we report the nucleotide and deduced amino acid sequences of one major thread IF subunit, alpha (pI 7.5), which is coexpressed with a second polypeptide, gamma (pI 5.3). These two polypeptides coassemble in vitro into approximately 10 nm filaments. The alpha-thread chain, a 66.6 kDa polypeptide, has an unusual central rod domain containing 318 residues flanked by N- and C-terminal domains of 192 and 133 residues, respectively. Each peripheral region exhibits some epidermal keratin-like features including peptide repeats and a high total content of glycine and serine residues. The terminal domains, however, lack the H1 and H2 subdomains characteristic of known keratins. Moreover, when the central rod is aligned either in relation to established homology profiles (J. F. Conway and D. A. D. Parry (1988) Int. J. Biol. Macromol. 10, 79-98) of other IF subunits (types I-V, nestin, non-neuronal invertebrate), or by computer-based homology searches of the GenBank/EMBL Data Bank, a low identity (< 30%) is evident, with no preferred identity to keratins or other known IF types. Although the central rod of 318 residues consists of the canonical apolar heptad repeats interspersed with three linker regions, a discontinuity in phasing of the heptad substructure in rod 2B, and conserved sequences at either end of the rod domain, other collective characteristics are atypical: overall high threonine content (13.2% vs 2.3-5.4% for other IFs), high threonine content in rod 1B (18.8% vs 1-6%), five Thr-Thr repeats in coiled coil segments, L12 of length greater than in keratins, substitution of phenylalanine for a highly conserved glutamate in the sixth position of L2, and a glycine-proline sequence in segment 2B. Possibly as a result of the high threonine content, the percentage of both acidic and basic residues in most helical subdomains is reduced relative to type I and II chains. Fast Fourier transform analyses show that only the acidic residues in segment 1B and basic residues in segment 2 have near typical IF periods.(ABSTRACT TRUNCATED AT 400 WORDS)
Accurate partition function and thermodynamic data for water (2000)

The partition function, Q, of H216O is calculated by explicit summation of about 10 500 experimental vibration-rotation energy levels and very high accuracy estimates are obtained for the specific heat capacity (Cp), the Gibbs enthalpy function (gef), the Helmholtz function (hcf) and the entropy (S) of gas phase water as a function of temperature. For temperatures above 600 K it is necessary to augment the sum with theoretical estimates of the energy levels. These are obtained from high accuracy variational calculations which are extended to dissociation using a model for rotational levels based on a Padé approximant. Estimates for the partition function and other thermodynamic quantities are obtained for temperatures up to 6000 K and temperature dependent error bars presented. All estimates are highly accurate with the exception of Cp for T&gt;5000 K, for which further work is required.
Survey of Wireless Communication Technologies for Public Safety (2014)

Public Safety (PS) organizations bring value to society by creating a stable and secure environment. The services they provide include protection of people, environment and assets and they address a large number of threats both natural and man-made, acts of terrorism, technological, radiological or environmental accidents. The capability to exchange information (e.g., voice and data) is essential to improve the coordination of PS officers during an emergency crisis and improve response efforts. Wireless communications are particularly important in field operations to support the mobility of first responders. Recent disasters have emphasized the need to enhance interoperability, capacity and broadband connectivity of the wireless networks used by PS organizations. This paper surveys the outstanding challenges in this area, the status of wireless communication technologies in this particular domain and the current regulatory, standardization and research activities to address the identified challenges, with a particular focus on USA and Europe.
Complex Regulation of the BRCA1 Gene (1997)

We have analyzed the promoter region of the human BRCA1 gene in detail and demonstrate that the expression of the BRCA1 gene is under complex regulation. First, its transcription is under the control of two promoters generating two distinct transcripts alpha and beta, and second, promoter alpha is shared with the adjacent NBR2 gene and is bi-directional. Both promoter alpha and promoter beta are responsive to estrogen stimulation. We also discerned that there are striking differences in both the genomic organization and immediate cis-control elements of the BRCA1 gene between humans and mice.
The chitinase C gene PsChiC from Pseudomonas sp. and its synergistic effects on larvicidal activity (2015)

Pseudomonas sp. strain TXG6-1, a chitinolytic gram-negative bacterium, was isolated from a vegetable field in Taixing city, Jiangsu Province, China. In this study, a Pseudomonas chitinase C gene (PsChiC) was isolated from the chromosomal DNA of this bacterium using a pair of specific primers. The PsChiC gene consisted of an open reading frame of 1443 nucleotides and encoded 480 amino acid residues with a calculated molecular mass of 51.66 kDa. The deduced PsChiC amino acid sequence lacked a signal sequence and consisted of a glycoside hydrolase family 18 catalytic domain responsible for chitinase activity, a fibronectin type III-like domain (FLD) and a C-terminal chitin-binding domain (ChBD). The amino acid sequence of PsChiCshowed high sequence homology (> 95%) with chitinase C from Serratia marcescens. SDS-PAGE showed that the molecular mass of chitinase PsChiC was 52 kDa. Chitinase assays revealed that the chitobiosidase and endochitinase activities of PsChiCwere 51.6- and 84.1-fold higher than those of pET30a, respectively. Although PsChiC showed little insecticidal activity towards Spodoptera litura larvae, an insecticidal assay indicated that PsChiC increased the insecticidal toxicity of SpltNPV by 1.78-fold at 192 h and hastened death. These results suggest that PsChiC from Pseudomonas sp. could be useful in improving the pathogenicity of baculoviruses.
Role-based access management for ad-hoc collaborative sharing (2006)

Under scientific collaborations, resource sharing tends to be highly dynamic and often ad hoc. The dynamic characteristics and sharing patterns of ad-hoc collaborative sharing impose a need for comprehensive and flexible approaches to reflect and cope with the unique access control requirements associated with the ad-hoc collaboration. In this paper, we propose a role-based access management framework to enable secure resource sharing,especially focusing on the digital information sharing in the heterogeneous scientific collaboration environments.Our framework incorporates role-based approach to address distributed access control, delegation and dissemination control involved in the resource sharing within such environments. A set of XACML-based policy schemas is proposed to specify policies on our framework. To demonstrate the feasibility of our framework, we design and implement a proof-of-concept prototype system called ShareEnabler, which is based on a peer-to-peer information sharing toolkit developed by Lawrence Berkeley National Laboratory.
A Simple Technique for High-Throughput Screening of Drugs That Modulate Normal and Psoriasis-Like Differentiation in Cultured Human Keratinocytes (2002)

Established treatments for psoriasis act ei-ther on hyperproliferation, inflammation, aberrant epidermal differentiation or a combination of these aspects of the disease. Potential new drugs for treatment of psoriasis or other disorders with abnormalities in epidermal differentiation can be identified by high-throughput screening of large compound libraries using surrogate markers for the disease. Here we describe a screening model to detect pharmacologically active drugs in two keratinocyte-based, 96-well culture models that use expression of cytokeratin 10 (CK10) and skin-derived antileucoprotease (SKALP)/elafin as markers for normal and psoriatic differentiation, respectively, and allow multiple parameters to be determined from a single well. In this model we tested a number of compounds in a pharmacological range from 10(-7) to 10(-5) M, including known antipsoriatic drugs, and experimental drugs that are potentially useful in the treatment of psoriasis. All-trans-retinoic acid, dithranol and the p38 mitogen-activated protein (MAP) kinase inhibitor SB220025 displayed a strong inhibitory effect on SKALP expression while cyclosporin A, dexamethasone, the vitamin D(3) derivative calcipotriol and the p38 MAP kinase inhibitor SB203580 showed only moderate inhibition. Methotrexate and dimethylfumarate did not affect the expression of SKALP. With respect to CK10 expression, all-trans-retinoic acid, calcipotriol, SB203580 and SB220025 exhibited strong inhibition while dithranol showed only moderate suppression of this normal differentiation marker. Expression levels of CK10 were not significantly affected by dexamethasone, methotrexate, cyclosporin A or dimethylfumarate. This model system parallels most, but not all, findings on the in vitro effect of known antipsoriatic drugs on keratinocytes. In addition, the model identifies p38 MAP kinase inhibitors as potent suppressors of differentiation-associated gene expression. Although further delineation and validation of this model is required, we conclude that the system is amenable to down-scaling and application as a high-throughput screen for differentiation-modifying compounds.
IO Workload Characterization Revisited: A Data-Mining Approach (2013)

Over the past few decades, IO workload characterization has been a critical issue for operating system and storage community. Even so, the issue still deserves investigation because of the continued introduction of novel storage devices such as solid-state drives (SSDs), which have different characteristics from traditional hard disks. We propose novel IO workload characterization and classification schemes, aiming at addressing three major issues: (i) deciding right mining algorithms for IO traffic analysis, (ii) determining a feature set to properly characterize IO workloads, and (iii) defining essential IO traffic classes state-of-the-art storage devices can exploit in their internal management. The proposed characterization scheme extracts basic attributes that can effectively represent the characteristics of IO workloads and, based on the attributes, finds representative access patterns in general workloads using various clustering algorithms. The proposed classification scheme finds a small number of representative patterns of a given workload that can be exploited for optimization either in the storage stack of the operating system or inside the storage device.
Heart Rate Variability During Waking and Sleep in Healthy Males and Females (1999)

The results confirmed changes in autonomic activity from waking to sleep, with marked differences between NREM and REM sleep. These changes were primarily due to stage-related alterations in vagal tone. REM sleep was characterized by increased sympathetic dominance, secondary to vagal withdrawal. The data also suggested gender differences in autonomic functioning during waking and sleep, with decreased vagal tone during waking and increased sympathetic dominance during REM sleep in the males.