gebhart/patrepeval huggingface dataset:
Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines. (1995)

To establish in vivo gonadal tumor models and permanent lines of gonadal somatic cells we produced transgenic (TG) mice expressing the Simian virus (SV) 40 T-antigens (T-ag), driven by 6 or 2.1 kilobase fragments of the mouse inhibin alpha-subunit promoter. Hitherto, altogether 44 TG mice, one of which carried the shorter transgene, have produced gonadal tumors. Two founder females expressing the longer transgene, KK1 and KK3, and three established TG mouse lines were studied in detail. Penetrance of the phenotype in IT6-M and IT6-F mouse lines was 100% (tumors/TG: IT6-M 22/22, IT6-F 14/14). The T-ag mRNA was strongly expressed in the gonads, adrenal glands, pituitary, and brain. The KK-1 and KK-3 ovarian tumor cells immunostained with anti-SV40 large-T antibody. The KK-1 cells possessed high-affinity LH receptors [equilibrium association constant (Ka = 7.8 x 10(10) liters/mol] and responded to human CG by elevated cAMP and progesterone production. Also FSH slightly stimulated their cAMP and estradiol production (P < 0.01). These cells expressed cytochrome P450arom and inhibin alpha mRNA, but not cytochrome P450c17 alpha. In conclusion, the KK-1 cells are immortalized luteinizing granulosa cells expressing endogenous gonadotropin receptors, steroidogenic enzymes, and inhibin alpha. These cells will be useful in studies on the molecular aspects of granulosa cell function. The present study indicates that the 6-kilobase fragment of the inhibin alpha promoter described in this article contains the elements directing tissue-specific expression in vivo and is useful for targeted expression of other genes in the gonads.
[Detection of reserpine-like substances in human and animal myocardia]. (1977)

<p>A key theme in ubiquitous computing is to create smart environments in which there is seamless integration of people, information, and physical reality. In this manuscript, we describe a set of tools that facilitate the creation of such environments, e,g, a service to transform videos recorded with mobile devices into navigable 3D scenes, a service to compute and describe the emotional processes that occur during the user interaction with such content, a service that takes into account certain dynamic needs of users in personalizing solutions for allocating their leisure time and activities, a gamified crowdsourcing application, and a set of projection-based tools for creating and interacting with augmented environments. Ultimately, our objective is have a framework that seamless integrates all these components, to foster creativity processes.</p>
Fall in antibody titer to bovine leukemia virus in the periparturient period. (1982)

Twenty-seven cows with antibodies to bovine leukemia virus were bled before, during and after calving. All serum samples were tested quantitatively for bovine leukemia virus antibodies using both the agar-gel immunodiffusion test with a glycoprotein antigen and the radioimmunoprecipitation assay with an internal p24 protein antigen. A significant fall (P less than 0.001) in bovine leukemia virus-antibody titer was demonstrated with both tests at the time of calving, with a subsequent rise in antibody titer within one month of parturition. Bovine leukemia virus antibodies were not detectable using the agar-gel immunodiffusion test in two of these cows at the time of calving.
Per(3-deoxy)-α-cyclomannin: an<i>n</i>-butanol hexahydrate inclusion complex (2003)

The host molecule in the title compound, cyclo­hexakis­[(1\rightarrow4)-3-deoxy-α-d-arabino-hexo­pyran­osyl] n-butanol hexahydrate, C36H60O24·C4H10O·6H2O, has a cavity similar in diameter but smaller in torus height than that of α-cyclo­dextrin, due to the axial C-2-hydroxyl groups pointing away from the ring plane. The mol­ecules have approximate C6 symmetry and pack into stacks with channels occupied by disordered n-butanol mol­ecules. Water of srystallization fills the space between the stacks. The structure was determined at 211 K.
ChemInform Abstract: COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT COMPOUNDS. 23. FOURIER TRANSFORM INFRARED SPECTROSCOPY OF FERRIC CATECHOYLAMIDE ANALOGUES OF ENTEROBACTIN (1983)

Abstract Durch Beobachtung der Carbonylschwingungsfrequenzen von Enterobactin (I) und den synthetischen Modellanalogen (ll)‐(IV) konnte die Art der Koordination des Fe(lI′l)‐lons in ihren Komplexen in saurem Medium bestimmt werden.
Enhancement or Attenuation of Disease by Deletion of Genes from <i>Citrus Tristeza Virus</i> (2012)

Stem pitting is a common virus-induced disease of perennial woody plants induced by a range of different viruses. The phenotype results from sporadic areas of the stem in which normal xylem and phloem development is prevented during growth of stems. These alterations interfere with carbohydrate transport, resulting in reduced plant growth and yield. Citrus tristeza virus (CTV), a phloem-limited closterovirus, induces economically important stem-pitting diseases of citrus. CTV has three nonconserved genes (p33, p18, and p13) that are not related to genes of other viruses and that are not required for systemic infection of some species of citrus, which allowed us to examine the effect of deletions of these genes on symptom phenotypes. In the most susceptible experimental host, Citrus macrophylla, the full-length virus causes only very mild stem-pitting symptoms. Surprisingly, we found that certain deletion combinations (p33 and p18 and/or p13) induced greatly increased stem-pitting symptoms, while other combinations (p13 or p13 plus p18) resulted in reduced stem pitting. These results suggest that the stem-pitting phenotype, which is one of more economically important disease phenotypes, can result not from a specific sequence or protein but from a balance between the expression of different viral genes. Unexpectedly, using green fluorescent protein-tagged full-length virus and deletion mutants (CTV9Δp33 and CTV9Δp33Δp18Δp13), the virus was found at pitted areas in abnormal locations outside the normal ring of phloem. Thus, increased stem pitting was associated not only with a prevention of xylem production but also with a proliferation of cells that supported viral replication, suggesting that at random areas of stems the virus can elicit changes in cellular differentiation and development.
Leucine aminopeptidases: diversity in structure and function (2006)

Leucine aminopeptidases (LAPs) are metallopeptidases that cleave N-terminal residues from proteins and peptides. While hydrolyzing Leu substrates, LAPs often have a broader specificity. LAPs are members of the M1 or M17 peptidase families, and therefore the LAP nomenclature is complex. LAPs are often viewed as cell maintenance enzymes with critical roles in turnover of peptides. In mammals, the M17 and M1 enzymes with LAP activity contribute to processing peptides for MHC I antigen presentation, processing of bioactive peptides (oxytocin, vasopressin, enkephalins), and vesicle trafficking to the plasma membrane. In microbes, the M17 LAPs have a role in proteolysis and have also acquired the ability to bind DNA. This property enables LAPs to serve as transcriptional repressors to control pyrimidine, alginate and cholera toxin biosynthesis, as well as mediate site-specific recombination events in plasmids and phages. In plants the roles of the M17 LAPs and the peptidases related to M1 LAPs are being elucidated. Roles in defense, membrane transport of auxin receptors, and meiosis have been implicated.
ChemInform Abstract: REVERSAL OF THE PHENYLSELENO‐ AND PHENYLSULFENO‐CYCLIZATIONS. SYNTHESIS OF OLEFINS FROM PHENYLSELENO‐ AND PHENYLSULFENO‐LACTONES, PHENYLSELENOETHERS, AND α‐HYDROXYSELENIDES (1979)

Abstract Der Phenylselenoether (I) wird durch Natrium in flüssigem Ammoniak zu einem 1:2,5‐Gemisch aus dem Prostaglandin PGFza (IIa) und seinem trans‐Isomeren (IIb) gespalten.
Multichannel adaptive enhancement of the electrogastrogram (1990)

The electrogastric signal can be measured cutaneously on the abdomen. This is attractive because it is harmless to patients or volunteers. However, the poor quality of the cutaneous measurements necessitates signal enhancements. Hence, in this paper, an adaptive multichannel signal enhancing system is proposed. The mu-vector least mean square (LMS) algorithm is applied to adjust the weights of the adaptive filters in the system. The detailed description and the performance analysis of the system is given in the paper. Applying the proposed system, the respiratory artifact, the electrode-skin noise, some of motion artifacts, and the electrocardiography (ECG) can be efficiently reduced while the characteristics of the relevant gastric signal is less affected.
Computational Fluid Dynamics Studies of a Flapping Wing Nano Air Vehicle (2010)

Abstract : The goal of this project is to develop a Nano Air Vehicle (NAV) with a wing span of 7.5 cm. The computational fluid dynamics study is focused on the aerodynamic efficiency of the wings. The primary focus of the computational study is on the aerodynamic performance of the wings in order to obtain a near optimal kinematics of the wing while the NAV is in a hover mode. The secondary effort was of a more fundamental nature, in order to understand the differences between a rotating helicopter blade and a similarly designed wing undergoing a flapping motion.
Neurotrophins: Which Way Did They Go? (2001)

The classic view of the neurotrophin as a messenger produced by the postsynaptic cell that signals survival to the presynaptic cell has become expanded. Segal discusses the evidence that the neurotrophin brain-derived nerve growth factor (BDNF) can be also released from the presynaptic cell onto the dendritic spine of a postsynaptic cell to regulate the neuronal circuit in two directions: forward (from presynaptic cell to postsynaptic dendrite) and the classic backward direction (from postsynaptic cell to the presynaptic axon). These results remind us that in the brain, neurons exist in a complex circuit and one neuron's presynaptic cell is another neuron's postsynaptic cell. The evidence that a single growth factor may have different actions based on the localization of the receipt of the signal adds more complexity to the brain's neuronal circuitry.
ChemInform Abstract: Benzocrown Derivatives as Ionophores for Alkali Cations. Part 2. Synthesis and Comparison of Urethane‐, Ether‐, and Ester‐Linked Bis‐Crown Compounds and Several “Crown‐Ring Free” Analogues. (1988)

Abstract The introduction of a NO 2 group into the title compounds (I) and (IV) does not improve their K + selectivities.
HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS (1989)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
CSF Neuropeptides in Euthymic Bipolar Patients and Controls (1987)

Levels of vasopressin, somatostatin, neurotensin, vasoactive intestinal peptide, corticotrophin-releasing factor and adrenocorticotrophin in CSF were determined in lithium-treated and unmedicated euthymic bipolar patients and controls, in a search for a trait marker in affective disorder. No group differences in levels of these peptides were found. Highly significant positive correlations were found among these peptides (with the exception of neurotensin), suggesting that their presence in CSF is functionally significant, as opposed to the result of random diffusion from the interstitial space of the brain.
Flux-creep studies of vortex pinning in an aligned<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">YBa</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mi mathvariant="normal">−</mml:mi><mml:mi mathvariant="normal">δ</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>superconductor with oxygen deficiencies δ≤0.2 (1992)

Flux-creep measurements were carried out in magnetically aligned, sintered samples of ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\delta}}}$ with various oxygen deficiencies \ensuremath{\delta} (in the range 0\ensuremath{\le}\ensuremath{\delta}\ensuremath{\le}0.2), for temperatures T in the range from 5 to 75 K, with an applied magnetic field H\ensuremath{\parallel}c axis of 1 T. The normalized flux-creep rate S=d lnM/d lnt was determined as a function of T and \ensuremath{\delta}. The effective vortex-pinning potential ${\mathit{U}}_{\mathrm{eff}}$(J) and the pinning energy ${\mathit{U}}_{0}$ were calculated both in the linear Anderson-Kim approximation as well as in the nonlinear formalism of vortex-glass and collective-pinning theory. The applicability of the nonlinear formalism was tested and discussed. There is a close correspondence between the energy scaling parameter ${\mathit{U}}_{0}$ of the nonlinear model and the pinning energy of a pointlike pinning center. A comparison of the experimental results with predictions of collective-pinning theory reveals a consistent picture of vortex motion in this family of superconductors.
Geranium carolinianum as an Early Host for Heliothis zea and H. virescens (Lepidoptera: Noctuidae) in the Southeastern United States, with Notes on Associated Parasites1 (1966)

Journal Article Geranium carolinianum as an Early Host for Heliothis zea and H. virescens (Lepidoptera: Noctuidae) in the Southeastern United States, with Notes on Associated Parasites Get access J. Wendell Snow, J. Wendell Snow 2Entomologist, Georgia Coastal Plain Experiment Station, Tifton Search for other works by this author on: Oxford Academic Google Scholar John J. Hamm, John J. Hamm 3Entomologist, Entomology Research Division, Agr. Res. Serv., USDA, Tifton, Ga Search for other works by this author on: Oxford Academic Google Scholar J. R. Brazzel J. R. Brazzel 4Professor, Department of Entomology, Mississippi Agricultural Experiment Station, State College Search for other works by this author on: Oxford Academic Google Scholar Annals of the Entomological Society of America, Volume 59, Issue 3, 1 May 1966, Pages 506–509, https://doi.org/10.1093/aesa/59.3.506 Published: 01 May 1966 Article history Accepted: 07 September 1965 Published: 01 May 1966
CHARACTERIZING DETONATING LX-17 CHARGES CROSSING A TRANSVERSE AIR GAP WITH EXPERIMENTS AND MODELING (2009)

Experiments were performed using detonating LX‐17 (92.5% TATB, 7.5% Kel‐F by weight) charges with various width transverse air gaps with manganin peizoresistive in‐situ gauges present. The experiments, performed with 25 mm diameter by 25 mm long LX‐17 pellets with the transverse air gap in between, showed that transverse gaps up to about 3 mm could be present without causing the detonation wave to fail to continue as a detonation. The Tarantula/JWL++ code was utilized to model the results and compare with the in‐situ gauge records with some agreement to the experimental data with additional work needed for a better match to the data. This work will present the experimental details as well as comparison to the model results.
ATP‐mediated intercellular calcium wave in renal (juxta)glomerular endothelial cells (GENC) (2007)

Autoregulatory mechanisms of the afferent arteriole (AA), the myogenic response and tubuloglomerular feedback (TGF), both involve extracellular ATP and purinergic calcium signaling. The calcium wave of TGF propagates to both contractile and endothelial cells. We aimed to identify the role of the endothelial cell membrane potential (Vm) or calcium [Ca 2+ ] i in signal propagation. The in vitro microperfused juxtaglomerular apparatus (JGA) and GENC cultures were loaded with ANNINE‐6, a newly synthesized membrane‐specific voltage‐sensitive dye, and Fluo‐4/Fura red to visualize Vm and [Ca 2+ ] i in real‐time using fluorescence confocal microscopy. In contrast to smooth muscle cells, vasoconstriction produced significant [Ca 2+ ] i but no Vm signals in GENCs. Mechanical stimulation of a single GENC caused a 4 ± 0.7‐fold (n=18) increase in [Ca 2+ ] i which was propagated throughout the monolayer (8 ± 0.3 μm/s) in a regenerative manner (without decrement of amplitude, kinetics, and speed) over distances >200μm. Consistent with Vm measurements, the voltage‐dependent calcium channel blocker nifedipine (10 μM) had no effect. Initiation and propagation of the calcium wave most likely involves mechanosensitive cation channels in the stimulated cell and extracellular ATP, respectively, since addition of a calcium channel blocker (La 3+ ) or an ATP scavenger cocktail (apyrase and hexokinase, 50 U/ml each) abolished them. These results demonstrate the existence of an endothelial calcium wave in the renal vasculature which may serve an important feedback role during vasoconstriction.
Side-hole polarization-maintaining photonic crystal fiber for hydrostatic pressure sensing (2011)

We propose a side-hole polarization-maintaining photonic crystal fiber (PM-PCF) with ultrahigh polarimetric sensitivity to hydrostatic pressure. Modal birefringence B as large as 2.34×10-3 and polarimetric pressure sensitivity dB/dp as high as -2.28×10-5 MPa-1 were achieved at 1.55 μm for the proposed fiber. Combining the advantages of both side-hole fibers and PM-PCFs, the proposed fiber is an ideal candidate for future applications of pressure sensing.
Effect of volatile organic compounds from Pinus sylvestris and Picea abies on Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and Salmonella enterica serovar Typhimurium (2017)

Pine and spruce heartwood and sapwood were milled to wood particles and the volatile organic compounds (VOCs) of the wood particles were tested against four bacterial strains. To study the influence of relative humidity on the antibacterial effect, both dry and wet wood particles were tested. Twenty microliters of the bacterial dilution with a concentration of 1.5 × 107 CFU ml−1 was cultured on glass surfaces in the presence of VOCs and the amount of viable bacteria was studied after 2, 4, and 24 h. The volatile emissions were evaluated by GC/MS and the results were compared with the results from the bacterial trial. VOCs had an antibacterial effect on Escherichia coli, Streptococcus pneumoniae and slightly on Salmonella enterica serovar Typhimurium. But the effect on Staphylococcus aureus was minute even after 3 days’ incubation. The dry wood particles generally had a stronger
antibacterial effect, though the amount of VOCs from the wet wood was higher. Pine heartwood had the strongest antibacterial effect and also the highest emissions of VOCs. However, the interaction between different bacterial strains and wood species shows some variations.
ChemInform Abstract: Chiral Building Blocks for Syntheses by Kolbe Electrolysis of Enantiomerically Pure β‐Hydroxybutyric Acid Derivatives. (1986)

Abstract The trifluoro butyric acid derivative (I) undergoes Kolbe electrolysis to give (II).
In the radiotherapy of prostate cancer, technique determines the doses to the penile structures. (1999)

For 11 consecutive prostate cancer patients undergoing three-dimensional conformal radiotherapy (3DCRT) in our institution, penile structures (PNS) were outlined in CT images obtained for treatment planning purposes. Dose-volume histograms (DVHs) were compared in order to study dose-volume relations for three techniques: 4FLD, an axial coplanar, four-field box technique; 6FLD, a six-field coplanar technique; and 4NAX, a coplanar but non-axial, four-field technique. All three techniques delivered equal doses to the planning target volumes (PTV). Our statistical analyses strongly indicate that the three techniques can be ranked as 6FLD better than 4FLD (and 4FLD better than 4NAX) as far as irradiating PNS volume during treatment of prostate cancer (PC) is concerned. For each technique, there is a "spread" owing to differences in patient anatomy and/or target size, position, and extent, but each technique has a similar "profile" or "shape" distinct from other techniques. Whether irradiating smaller volumes of PNS will influence the sexual potency outcome remains to be demonstrated. However, PNS should be considered as another critical structure in addition to rectum, bladder and femoral heads in the radiotherapy (RT) of PC, especially in 3DCRT dose escalation studies. Sexual potency outcomes can be correlated to dose-volume relations in the future and this will help refine radiotherapy techniques further.
Determining the potential in the Schrödinger equation from the Dirichlet to Neumann map by the boundary control method (2005)

We consider the problem of identifying the potential in the one-dimensional Schrödinger equation with input Dirichlet data, from measured Neumann data. Knowledge of the Dirichlet to Neumann map together with spectral controllability results for the Schrödinger equation obtained using properties of exponential Riesz bases allow recovery of the spectral data. Once the the spectral data is recovered, we use the Boundary Control method to solve the identification problem.
Pulmonary Lymph: Demonstration of Its High Oxygen Tension Relative to Systemic Lymph. (1965)

Po2 in right lymph duct of 15 anesthetized dogs averaged the same as in arterial blood (75 ± 18 mm Hg); Po2 in thoracic duct lymph was close to that in mixed-venous blood (34 ± 20 mm Hg). Allowing for admixture of systemic lymph in the right duct, Po2 in lymph from the respiratory portion of the lung must fall between alveolar gas and arterial blood. The marked difference from thoracic duct lymph P02 (p<.001) supports the concept of lymph as a useful measure of Po2 in interstitial fluid and tissues. Use of mixing equations shows that during air breathing respiratory (i.e., gas-exchanging) tissues contributed at least 53% of right duct lymph flow.
Comparative Gene Expression Profiling Identifies Common Molecular Signatures of NF-κB Activation in Canine and Human Diffuse Large B Cell Lymphoma (DLBCL) (2013)

We present the first comparison of global transcriptional changes in canine and human diffuse large B-cell lymphoma (DLBCL), with particular reference to the nuclear factor-kappa B (NF-κB) pathway. Microarray data generated from canine DLBCL and normal lymph nodes were used for differential expression, co-expression and pathway analyses, and compared with analysis of microarray data from human healthy and DLBCL lymph nodes. The comparisons at gene level were performed by mapping the probesets in canine microarrays to orthologous genes in humans and vice versa. A considerable number of differentially expressed genes between canine lymphoma and healthy lymph node samples were also found differentially expressed between human DLBCL and healthy lymph node samples. Principal component analysis using a literature-derived NF-κB target gene set mapped to orthologous canine array probesets and human array probesets clearly separated the healthy and cancer samples in both datasets. The analysis demonstrated that for both human and canine DLBCL there is activation of the NF-κB/p65 canonical pathway, indicating that canine lymphoma could be used as a model to study NF-κB-targeted therapeutics for human lymphoma. To validate this, tissue arrays were generated for canine and human NHL and immunohistochemistry was employed to assess NF-κB activation status. In addition, human and canine B-cell lymphoma lines were assessed for NF-κB activity and the effects of NF-κB inhibition.