gebhart/patrepeval huggingface dataset:
Phase Behavior and Properties of a Microemulsion in the Presence of NaCl (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhase Behavior and Properties of a Microemulsion in the Presence of NaClAjith Cherian John and Animesh Kumar RakshitCite this: Langmuir 1994, 10, 7, 2084–2087Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/la00019a012https://doi.org/10.1021/la00019a012research-articleACS PublicationsRequest reuse permissionsArticle Views284Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biochemical effects of chlorpromazine on mouse neuroblastoma cells. (1999)

Chlorpromazine and other phenothiazine derivatives are neuroleptic drugs of widespread use for clinical situations beyond the realm of psychiatry, such as to control nausea, vomiting and intractable hiccups. The present study investigated in vitro different cytotoxic effects of chlorpromazine in cultures of mouse neuroblastoma cell line Neuro-2a exposed to different concentrations of this compound. Indicators assessed were cell proliferation by quantification of total protein content of the cell culture, lysosomal function evaluated by the relative uptake of neutral red cytosolic phosphofructokinase (PFK) and enolase (ENL) activities in glycolysis, mitochondrial succinate dehydrogenase (SDH) activity in the citric acid cycle, lysosomal beta-galactosidase (GAL) activity, and neuronal acetylcholinesterase activity. Marked inhibitory effects were found for cell proliferation and relative neutral red uptake; PFK, ENL and GAL activities had no significant differences from control. Stimulation was specifically detected on SDH and the Krebs cycle at concentrations up to 30 microM. Chlorpromazine did not have high toxicity for cytotoxic effects on lysosomes.
Protection from Excessive Resuscitation: “Pushing the Pendulum Back” (2000)

Address for reprints: Basil A. Pruitt, Jr., MD, The Journal of Trauma Editorial Office, 7330 San Pedro Avenue, Suite 654, San Antonio, TX 78216; e-mail: [email protected]
Experimental Bond Behavior of FRP Sheets Glued on Brick Masonry (2010)

This paper deals with the experimental characterization of the mechanical tensile and shear bond behavior of fiber-reinforced polymer (FRP) sheets externally glued on masonry prisms, in terms of load capacity and stress distribution along the bonded length. The brick masonry adopted tries to replicate ancient brick masonry, by using handmade low-strength solids bricks and low-strength lime-based mortar. Key parameters relative to the FRP-masonry interface response, particularly bonded length, FRP materials, anchor scheme adopted, and shape of masonry substrate, were studied. Finally, an analytical bond stress-slip formulation was developed, allowing deducing local bond stress-slip curves directly from the experiments.
Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors (2000)

Heme, the heavy metals cadmium and bismuth, as well as NO donors, are potent inhibitors of cytokine induced iNOS activity. Heme and NO donors act at the transcriptional level inhibiting iNOS mRNA expression. Such findings suggest the potential for interplay between the iNOS and HO-1 systems, which may modulate the progress of IBD.
Computer Analysis of the RR Interval-Contractility Relationship during Random Stimulation of the Isolated Heart (1968)

Hemodynamic variability in patients with atrial fibrillation may originate from a direct influence of the variations in RR intervals on myocardial contractility. With the aid of a computer the serial autocorrelation function and the histogram of the RR intervals of patients with atrial fibrillation receiving no medication were produced. The RR intervals were randomly distributed and the histograms rather skew. Next, random rhythms with histograms matching those of the patients were produced with a radioactive source and a Geiger-Müller counter. These rhythms were used to stimulate isolated perfused rat hearts to study the relationship between the RR interval and a number of contractile parameters. The ECG and the isotonic contractions were digitized and processed by the computer. Serial crosscorrelation coefficients were computed between the RR interval on the one hand, and contraction height, contraction area, and maximum of the first derivative of the contraction on the other hand. The zero order crosscorrelation coefficient between the RR interval and contraction height was 0.6, between the RR interval and contraction area 0.8, and between the RR interval and maximum of first derivative 0.5. Although small, the first and second to approximately the tenth order coefficients were definitely negative. It is concluded that during a random rhythm the contractile parameters of an isolated heart are strongly related to the preceding RR interval. It is conceivable that this relation contributes to the variability of hemodynamic parameters during atrial fibrillation in man.
The use of electric network analyzers for pipe network analysis (1954)

THE determination of fluid-flow and pressure drop in complicated pipe networks such as gas or water distribution systems presents many problems similar to those encountered by the electrical engineer in the study of transmission and distribution networks. As the network analyzer has proved to be a very great help to the electrical engineer in his studies, it seems reasonable that similar techniques utilizing similar analyzers would be of considerable value in the analysis of pipe networks. Several investigators have reported methods for applying network analyzer techniques to gas or water distribution problems, some using special handling of conventional analyzers and others using special analyzers built solely for fluid-flow problems.
Oxygen effects on the nickel- and iron-containing hydrogenase from Azotobacter vinelandii (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen effects on the nickel- and iron-containing hydrogenase from Azotobacter vinelandiiLance C. Seefeldt and Daniel J. ArpCite this: Biochemistry 1989, 28, 4, 1588–1596Publication Date (Print):February 21, 1989Publication History Published online1 May 2002Published inissue 21 February 1989https://pubs.acs.org/doi/10.1021/bi00430a025https://doi.org/10.1021/bi00430a025research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Subgenomic RNA synthesis directed by a synthetic defective interfering RNA of mouse hepatitis virus: a study of coronavirus transcription initiation (1994)

We have used a full-length cDNA clone of a mouse hepatitis virus strain A59 defective interfering (DI) RNA, pMIDI-C, and cassette mutagenesis to study the mechanism of coronavirus subgenomic mRNA synthesis. Promoter sequences closely resembling those of subgenomic mRNAs 3 and 7 were inserted into MIDI-C. Both subgenomic RNA promoters gave rise to the synthesis of a subgenomic DI RNA in virus-infected and DI RNA-transfected cells. From a mutagenic analysis of the promoters we concluded the following. (i) The extent of base pairing between the leader RNA and the intergenic promoter sequence does not control subgenomic RNA abundance. (ii) Promoter recognition does not rely on base pairing only. Presumably, transcription initiation requires recognition of the promoter sequence by the transcriptase. (iii) Fusion of leader and body sequences takes place at multiple--possibly random--sites within the intergenic promoter sequence. A model is presented in which, prior to elongation, the leader RNA is trimmed by a processive 3'-->5' nuclease.
Sexually Antagonistic Genes: Experimental Evidence (1992)

When selection differs between the sexes, a mutation beneficial to one sex may be harmful to the other (sexually antagonistic). Because the sexes share a common gene pool, selection in one sex can interfere with the other's adaptive evolution. Theory predicts that sexually antagonistic mutations should accumulate in tight linkage with a new sex-determining gene, even when the harm to benefit ratio is high. Genetic markers and artificial selection were used to make a pair of autosomal genes segregate like a new pair of sex-determining genes in a Drosophila melanogaster model system. A 29-generation study provides experimental evidence that sexually antagonistic genes may be common in nature and will accumulate in response to a new sex-determining gene.
Laminarase of <i>Euglena gracilis</i> (1960)

An enzyme in extracts of the protistan Euglena gracilis splits the polysaccharide laminarin (beta-1:3-glucosan). Its optimal pH is 5.0, and it is activated by Mn(++) ions.
Following social capital: its formation, mobilization and maintenance in Vietnamese housing upgrading projects : A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Lincoln University (2017)

Social capital theory has been adopted in urban governance studies to promote democracy and inclusion through processes of communities’ active citizenship and political participation. The meaning and approach of defining social capital in relation to urban governance issues still remain ambiguous. Social capital’s theoretical application seems to remain elastic. This thesis set out with a general objective to critically examine how social capital operates in a local collective and community-based process. Specifically, the study utilizes the categorization of social capital dimensions as bonding, bridging and linking relations to explore how these social relation dimensions were formed, mobilized and maintained in a community-based housing upgrading process. To achieve its objectives, the study employs two qualitative case studies of community-based housing upgrading projects of the Asian Coalition of Community Action Programme in Vietnam: the Friendship housing project in Vinh city and Binh Dong 1 housing project in Tan An city. The research therefore seeks to both confirm the applicability of such social capital concepts in the Vietnam context and explore particularly aspects of the formation, mobilisation and maintenance of these types of social capital in these projects. The study findings suggest a framework that allows a synesthetic understanding of the operation of social capital regarding its components (trust, cooperation, other behavioural norms), levels (individuals, communities, network, state), formation approach (civil society or state-centred) and the interrelation of social capital dimensions (bonding, bridging and linking). Such a social capital operation framework necessitates multi-levels of societal resources in the formation of social capital. In addition, it accentuates the internal and contextual operation of key social capital components (i.e., trust, cooperation, attitudinal behaviours). Insights into a mixed approach of social capital formation are provided; they move beyond the dichotomy of civil-society and the state. The study draws attention to the interrelationship among bonding, bridging and linking capitals, raising a question regarding the hybrid nature of social capital dimensions. In addition, the study emphasizes that the mobilization of bonding, bridging and linking capital is interdependent and adaptable, and that the maintenance of social capital is unpredictable because conditions enabling social capital to form, or generate, are uncertain, being both conditional and unstable. Overall, the study concludes on a holistic approach to the formation, mobilization and maintenance of social capital within and between bonded, bridged and linked groups of such projects within the Vietnamese context and perhaps elsewhere.
A Controlled Trial of Amantadine Hydrochloride and Neuroleptics in the Treatment of Tardive Dyskinesia (1997)

An 18-week, double-blind, crossover study of amantadine and neuroleptics in the treatment of tardive dyskinesia (TD) is described. A fixed-dose regimen was used, and objective rating scales for TD, extrapyramidal symptoms, and mental state were employed. The results indicate that amantadine is significantly better than placebo in the management of TD and that there is little risk of exacerbating psychosis. Further investigation of this potentially useful medication is warranted.
Nematic liquid‐crystal technology for Si wafer‐based reflective spatial light modulators (2002)

Abstract— Various nematic LC modes are reviewed and compared in terms optical throughput, driving voltage, response time, contrast ratio, and spectral responses for LCoS applications. The effects of fringe‐field‐induced disclination on display performance and the mechanism of slow response of the disclination line between two topologically non‐equivalent LC states will be discussed. Issues involving flicker and photo‐instability of LCoS displays will be addressed as well.
Peripheral nerve regeneration with conduits: use of vein tubes (2015)

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.
CXXIX.—The action of phosphorus pentachloride on benzamide (1909)

A. W. Titherley and E. Worrall, J. Chem. Soc., Trans., 1909, 95, 1143 DOI: 10.1039/CT9099501143
Rearchitecting MapReduce for Heterogeneous Multicore Processors with Explicitly Managed Memories (2010)

This paper presents a new design and an implementation of the runtime system of MapReduce for heterogeneous multicore processors with explicitly managed local memories. We advance the state of the art in runtime support for MapReduce using five instruments: (1) A new multi-threaded, event-driven controller for task instantiation, task scheduling, synchronization, and bulk-synchronous execution of MapReduce stages. The controller improves utilization of control efficient cores, minimizes control overhead in the runtime system, and overlaps task instantiation with task scheduling on compute-efficient cores. (2) An implicit partitioning scheme which eliminates redundant memory copies. (3) An adaptive memory management scheme which combines efficient memory preallocation for applications with statically known output volume with dynamic allocation using runahead tasks for applications with statically unknown output volume. (4) An optimized quick-sort/merge-sort scheme which reduces the critical path length of merge-sort. (5) An optimized execution scheme which avoids redundant data transfers to and from local stores in applications that emit keys with the same value. Put together, these techniques accelerate representative MapReduce workloads by a factor of 1.81x (geometric mean) compared to a reference design that represents the state of the art.
Early Remodeling of Saphenous Vein Grafts: Proliferation, Migration and Apoptosis of Adventitial and Medial Cells Occur Simultaneously with Changes in Graft Diameter and Blood Flow (2000)

These results indicate that cell proliferation and apoptosis occur simultaneously within the adventitia and media of the vein during the first week following grafting, when changes in diameter and blood flow are greatest. In addition, proliferating adventitial cells subsequently migrate inwards to contribute to the formation of neointima.
Douleur et antiépileptiques. Aspects cliniques (1999)

Les antiépileptiques sont couramment utilisés dans le traitement de la douleur. Ils incluent désormais, à côté des antiépileptiques courants (carbamazépine, phénytoïne, clonazépam, valproate de sodium), les nouveaux antiépileptiques, notamment la gabapentine et la lamotrigine. Leur efficacité a été confirmée sur la base d’essais randomisés, contrôlés versus placebo, dans la névralgie du trijumeau (carbamazépine: 3 études, lamotrigine: 1 étude), les douleurs neuropathiques du diabète (gabapentine: 1 étude, à moindre degré carbamazépine: 1 petite étude et phénytoïne: 3 études dont une négative), l’algie post-zostérienne pour la gabapentine (1 étude) et le traitement de fond de la migraine (valproate de sodium: 4 études, carbamazépine et gabapentine: 1 étude chacun). La carbamazépine reste le traitement de première intention de la névralgie du trijumeau et le valproate est l’antiépileptique de référence dans le traitement de fond de la migraine. Les nouveaux antiépileptiques, généralement bien tolérés, devraient connaître une utilisation de plus en plus large dans diverses douleurs neuropathiques.
Amphetamine extended-release oral suspension for attention-deficit/hyperactivity disorder (2019)

<b>Introduction</b>: Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder known to respond to amphetamine (AMPH). Multiple AMPH formulations have been developed during the past two decades and have focused mainly on extending the duration of effect. AMPH extended-release oral suspension, Dyanavel XR, (AMPH EROS) was developed to address the unmet needs of patients who have difficulty swallowing intact extended-release (ER) tablets and capsules. <b>Areas covered</b>: The pharmacokinetic profile of the AMPH EROS in children and adults is discussed along with the technology responsible for its release profile. Efficacy data from two clinical trials are presented and AMPH EROS is compared with other marketed AMPH ER formulations in the United States. <b>Expert opinion</b>: Multiple AMPH ER formulations that do not require ingestion of an intact tablet or capsule have been developed. Initial products allowed for sprinkling or dissolving of capsule contents. Recently, oral disintegrating tablets, chewable tablets, and oral suspensions have been marketed. Each formulation has positive attributes. Tablets may be more portable. However, as a suspension, AMPH EROS dosing can differ depending on daily requirements. Dose can also be titrated with a single prescription. Despite its convenience, AMPH EROS is a branded product, so price may be prohibitive for some patients.
OSPF and IS-IS : Choosing an IGP for Large-Scale Networks (2005)

The practical guide to large-scale networking with OSPF and IS-ISThis is the definitive guide to using OSPF and IS-IS protocols in large-scale IP enterprise, carrier, and service provider networks. Well-known network designer Jeff Doyle draws on his consulting experience, offering realistic advice and straight answers on every aspect of working with link-state protocols-from scalability, reliability, and security to area design and database synchronization.This book is organized to help network engineers and architects compare OSPF and IS-IS. One feature at a time, Doyle first demonstrates how a topic or feature is implemented in OSPF, and then walks through a similar implementation using IS-IS. Professionals who are relatively new to large-scale networking will welcome his practical introduction to the concepts, goals, and history of link state protocols. Coverage includes Understanding message types, encapsulation, architecture, LSAs, and LSPs Optimizing addressing, neighbor discovery, adjacencies, and router designation Improving scalability: controlling the scope of flooding, link state database size, SPF calculation efficiency, and much more Designing and operating large-scale networks for maximum security and reliability Hardening networks to thwart attacks against routing protocols Comparing OSPF and IS-IS extensibility Utilizing extensions for MPLS-based traffic engineering, IPv6, and multi-topology routing Troubleshooting OSPF and IS-IS log entries, debug output, and LS databasesDoyle's thorough explanations, end-of-chapter review questions, and many wide-ranging examples for both Cisco's IOS and Juniper's JUNOS also make this book an exceptional resource for anyone pursuing a CCIE or JNCIE certification.© Copyright Pearson Education. All rights reserved.
A New Naphthylacetamide Derivative (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Naphthylacetamide DerivativeTiberio Bruzzese and Carla TurbaCite this: J. Med. Chem. 1966, 9, 2, 264Publication Date (Print):March 1, 1966Publication History Published online1 May 2002Published inissue 1 March 1966https://pubs.acs.org/doi/10.1021/jm00320a039https://doi.org/10.1021/jm00320a039research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts