gebhart/patrepeval huggingface dataset:
Coherent Optical Imaging through Opaque Layers (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text E. G. van Putten, D. Akbulut, J. Bertolotti, A. Lagendijk, and A. P. Mosk, "Coherent Optical Imaging through Opaque Layers," in Optics in the Life Sciences, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper NTuA4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Electrochemical Pore Etching in n- and p-Type Ge (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Aminopyridazine muscarinic agonist, SR 95639A, is a functional M<sub>2</sub> receptor antagonist in rat brain (1991)

Abstract The minaprine analog SR 95639A (morpholinoethylamino‐3‐benzocylohepta‐(5,6‐c)pyridazine dihydrochloride), a putative muscarinic M 1 receptor agonist, was evaluated for muscarinic activity in a number of biochemical and behavioral tests. Binding studies indicated that SR 95639A was 4‐fold selective for the M 1 receptor. In contrast, both carbachol and the Merck “super agonist,” L 670,207, were 50‐fold selective for the M 2 receptor, with Ki values of 47 μM and 100nM at the M 1 receptor and 1 μM and 2nM at the M 2 receptor, respectively. At concentrations up to 1 mM, SR 95639A had no effect on M 1 receptor‐evoked phosphatidyl inositol (Pl) hydrolysis, while carbachol and L 670,207 had EC 50 values of 116±10 μM and 0.60±0.12 μM respectively. SR 95639A (100 μM) did not inhibit the Pl response elicited by carbachol. At striatal M 2 receptors linked to inhibition of forskolin‐mediated cyclic AMP production, SR 95639A at concentrations up to 100 μM had no agonist activity, while carbachol and L 670,207 had respective EC 50 values of 540±31 nM and 2.9±0.5 nM. However, SR 95639A was an effective antagonist (K app = 3.50±0.45 μM; n = 5) of the carbachol response. In a rat radial arm maze paradigm, SR 95639A did not enhance cognitive performance and was unable to reverse deficits induced by scopolamine. The compound produced a dose‐dependent increase in mouse locomotor activity and did not attenuate the effects of scopolamine on habituation, but did potentiate oxotremorineinduced hypothermia.
Notizen: Zur Synthese von 4-Formyl-chinolin-2-carbonsäuren / Synthesis of 4-Formyl-quinoline-2-carboxylic Acids (1975)

The reaction of o-aminophenylglyoxal dimethylacetales with sodium pyruvate in the presence of sodium ethoxide yields 4-dimethoxymethyl-quinoline-2-carboxylic acids which give the title compounds on acid hydrolysis.
Chemical characterization of the degradation products of vinblastine dihydrogen sulfate. (1985)

Vinblastine was incubated in 0.2 M glycine buffer (pH 7.4 or 8.8) containing bovine serum albumin (1%) at 37 degrees C for 72 h. The reaction mixture was extracted with CH2Cl2, and the extract gave 6 major peaks (A, B, C, D, E, and F) with retention times of 5.0, 7.5, 11.0, 13.0, 23.0, and 30.0 min, respectively, in a high-performance liquid chromatography system (muBondapak C18 column; solvent, 50% MeOH in 10 mM KH2PO4, pH 4.5; flow rate, 1.2 ml/min; detector, 254 nm). Vinblastine in this system corresponded with peak C, and its spectral data were identical to those of the parent compound. The UV, infrared, and mass spectral properties of these peaks were as follows [UV (lambda max); infrared (cm-1); mass spectrum (m/z)]: peak A: 214, 266, and 315 nm; 3464, 2850, and 1730; and 769 (MH+); peak B: 213, 258, 285, and 295 nm; 3457, 2951, 2580, and 1734; and 809 (MH+); peak C: 214, 266, 292, and 312 nm; 3457, 2951, and 1734; and 811 (MH+); peak D: 212, 266, 285, and 312 nm; 3467, 2915, and 1734; and 811 (MH+); peak E: 212, 260, 285, 294, and 313 nm; 3479, 2850, and 1734; and 825 (MH+); and peak F: 212, 265, 283, and 312 nm; 3407, 2857, and 1734; and 807 (MH+). These data suggest the following tentative structures for the degradation products: peak A, 4-deacetylvinblastine; peak B, 19'-hydroxy-3',4'-dehydrovinblastine; peak D, an isomer of vinblastine; peak E, 19'-oxovinblastine; and peak F, 3',4'-dehydro-19'-oxovinblastine. The structure of peak A as 4-deacetylvinblastine was further confirmed by chemical synthesis.
Synthesis of the prostaglandin H2 analogue DL-9,11-ethano-9,11-dideoxaprostaglandin H2 (1981)

T. Kametani, T. Suzuki, S. Kamada and K. Unno, J. Chem. Soc., Perkin Trans. 1, 1981, 3101 DOI: 10.1039/P19810003101
Performance analysis of pC++: a portable data-parallel programming system for scalable parallel computers (2002)

pC++ is a language extension to C++ designed to allow programmers to compose distributed data structures with parallel execution semantics. These data structures are organized as "concurrent aggregate" collection classes which can be aligned and distributed over the memory hierarchy of a parallel machine in a manner consistent with the High Performance Fortran Forum (HPF) directives for Fortran 90. pC++ allows the user to write portable and efficient code which will run on a wide range of scalable parallel computers. We discuss the performance analysis of the pC++ programming system. We describe the performance tools developed and include scalability measurements for four benchmark programs: a "nearest neighbor" grid computation, a fast Poisson solver, and the "Embar" and "Sparse" codes from the NAS suite. In addition to speedup numbers, we present a detailed analysis highlighting performance issues at the language, runtime system, and target system levels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A retrospective study of parameters influencing survival after surgical resection of lung metastases of bone and soft tissue sarcomas (2009)

10541 Background: Due to the high rate of isolated lung metastases of sarcomas, a multidisciplinary approach combining chemotherapy with pulmonary metastasectomy (PM) is helpful to achieve R0 resection and try to increase progression free survival (PFS) and overall survival (OS). The aim of this retrospective study is to describe the clinical and tumor features of 70 consecutive operated patients and to identify the factors influencing survival. Methods: 70 patients undergoing PM at Foch Hospital or CCML between 1995 and 2006 were identified, with follow-up (FU) for a minimum of 3 years after last PM. Statview program has been used to create survival curves, Cox proportional hazard model for multivariate analysis. Results: 64 patients had grade II/III sarcomas of mainly lower limb origin.15 patients had synchronous lung metastases, 35 showed bilateral lesions (mean number of 4, mean size of 12 mm). No patient had extrapulmonary disease at the time of PM. 51% were primary bone sarcomas (24 osteo, 9 Ewing, 3 chondro) and 49 % were soft tissue sarcomas (including 12 synovial, 9 leio). The primary tumor treatment consisted in conservative surgery in 58 patients (83%). 49 patients received neo and/or adjuvant chemotherapy, 22 patients had postoperative radiotherapy. All patients underwent PM: 1 pneumonectomy, 15 lobectomy and 54 wedge resection. 21 patients required bilateral PM. The resection margins were classified R0/R1/R2 in 54/16/0 patients, R0 was confirmed in 44 by CT scan in a month after PM. With a median FU from diagnosis of 7.7 years, the median OS for all patients reached 59 months, and the median survival after metastasectomy (OSPM) 31 months. The 5-year OS and OSPM rates were 77% and 59% respectively. The mean PFS was 20 months. 25 patients underwent subsequent PM for recurrent lung metastases, 30 are still alive. On univariate analysis, primary high grade, DFI>24 months, number of metastases>3 and largest diameter>25 mm were significant negative factors for OS. Multivariate analysis confirmed the importance of high grade, DFI, and size of metastases for OS. R0 was associated with prolonged PFS after PM. Conclusions: Accurate patient selection and technical aspects of PM are related to optimal R0 rate. DFI may be a surrogate marker for tumor biology. No significant financial relationships to disclose.
Imprinted Membranes for Sensor Technology:  Opposite Behavior of Covalently and Noncovalently Imprinted Membranes (1998)

New types of polymeric membranes with molecular recognition sites for l-phenylalanine (l-Phe), 6-amino-1-propyluracil (APU), atrazine, and sialic acid have been prepared using the molecular imprinting approach. The membrane synthesis includes radical polymerization of ethylene glycol dimethacrylate (EDMA) and functional monomers in the presence of a template. Several compounds(diethylamino)ethyl methacrylate (DEAEM), methacrylic acid (MAA), allylamine (AA), and (4-vinylphenyl)boronic acidwere as functional monomers, which are able to form covalent, ionic, or hydrogen bonds with the corresponding templates. Template specific conductometric sensors, based on these polymers, were constructed and studied. An opposite response of covalently versus noncovalently imprinted membranes was demonstrated and discussed in detail. Sensors based on these materials could detect the target molecules at concentrations of 1−50 μM in solution. The high specificity and stability of these imprinted membranes render them promising alternatives to enzymes, antibodies, and other natural receptors usually used in sensor technology.
ChemInform Abstract: SYNTHESIS OF 1,1,1‐TRIS(2‐HYDROXYETHYL)AMINE‐2‐ACYLIMIDE (1977)

Abstract Durch Erhitzen eines Gemisches von Fettsäureestern (I), Hydrazinhydrat (II) und Äthylenoxid (III) in einem Lösungsmittel gelangt man in einer Stufe zu den oberflächenaktiven Aminoimiden (IV).
Structure of dicyclopentadienedicarboxylic acid and its dihydro and tetrahydro derivatives (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of dicyclopentadienedicarboxylic acid and its dihydro and tetrahydro derivativesConstantine J. BouboulisCite this: J. Org. Chem. 1967, 32, 11, 3540–3543Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/jo01286a056https://doi.org/10.1021/jo01286a056research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Consistent, convergent, and constant-time SLAM (2003)

This paper presents a new efficient algorithm for simultaneous localization and mapping (SLAM), using multiple overlapping submaps, each built with respect to a local frame of reference defined by one of the features in the submap. The global position of each submap is estimated using information from other submaps in an efficient, provably consistent manner. For situations where the mobile robot is able to make repeated visits to all regions of the environment, the method achieves convergence to a near-optimal result with time complexity while maintaining consistent error bounds. Simulation results demonstrate the ability of the technique to converge to errors that are only slightly greater than the full solution, while maintaining consistency. 1
Phase 1 Safety and Pharmacokinetics of the Novel Enzyme Replacement Therapy neoGAA in Treatment-Naïve and Alglucosidase Alfa-Treated Late-Onset Pompe Disease Patients (S38.005) (2016)

OBJECTIVE: This randomized open-label, ascending-dose study evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and exploratory efficacy of the second-generation, recombinant acid alpha-glucosidase replacement, neoGAA, in treatment-naïve (Grp 1) and alglucosidase alfa-treated (Grp 2) patients with late-onset Pompe disease (NCT01898364). BACKGROUND: The primary study objectives, safety profile and PK, are reported here. DESIGN/METHODS: Patients aged ≥18 years with acid α-glucosidase enzyme deficiency received IV neoGAA (5, 10, or 20mg/kg every other week) for 24 wks. RESULTS: 10 patients were treated in Grp 1; 9 completed (5mg/kg, n=3; 10mg/kg, n=3; 20mg/kg, n=3). 14 patients were treated in Grp 2; 12 completed (5mg/kg, n=3; 10mg/kg, n=4; 20mg/kg, n=5). There were no deaths or life-threatening SAEs. One Grp 1 patient had drug- and infusion-related SAEs (respiratory distress and chest discomfort); whereas in Grp 2, there were no drug-related SAEs. 4/10 Grp 1 patients had 11 infusion-associated reactions (IARs); 4 of 14 Grp 2 patients had 14 IARs. The majority of treatment-emergent AEs and IARs were non-serious and mild to moderate in intensity. In Grp 1, 9/10 patients developed anti-neoGAA antibodies, which inhibited uptake in 1 patient. In Grp 2, 5/14 patients had anti-neoGAA antibodies at screening/wk 1 although they had only been exposed to rhGAA. 2 of the 9 without baseline anti-neoGAA seroconverted without uptake inhibition. No enzyme-inhibitory antibodies or development of IgE antibodies occurred. NeoGAA plasma concentrations declined monoexponentially after infusion; mean t1/2 was 1.0 h in both groups. NeoGAA PK was similar in Grps 1 and 2 and remained largely unchanged between weeks 1, 13, and 25. 19/21 study completers entered the extension study and continue participating. CONCLUSIONS: NeoGAA had a well-tolerated safety profile in treatment-naïve and previously treated patients with late-onset Pompe disease. These findings support further development of neoGAA in Pompe disease. Study Supported by: Genzyme, a Sanofi Company
Series Introduction: COX in a crystal ball: current status and future promise of prostaglandin research (2001)

Prostaglandins were first discovered by von Euler in the late 1940s to be active principles in semen that induced uterine contractility. Since then, interest in the field has waxed and waned. Indeed, through much of the 50s and 60s, prostaglandin research remained the arcane preserve of the dedicated few. It maintained a continuing emphasis on reproductive biology but was eclipsed in the popular vision by those other stepchildren of von Euler’s creativity, the catecholamines.
Overview of Johne's disease immunology (2013)

Johne's disease or paratuberculosis is one of the most economically important diseases of the livestock. Most of the economic losses associated with paratuberculosis are related to decreased milk production, reduced fertility and higher rates of culling. Understanding the immunology of the disease is very important for better understanding of the interplay between the host and the causative agent, Mycobacterium avium subsp. paratuberculosis (MAP). After uptake of MAP by macrophages residing in host's intestinal tissue, two possible scenarios may emerge; MAP may be destroyed or may establish persistent infection within the macrophages. If MAP persists in the infected macrophage, it continuously modulates adaptive immune responses of the animal. In this short review we describe the host-pathogen interactions in Johne's disease and highlights potential protective mechanisms in order for future design of more effective diagnostic method and vaccine.
Electron-beam lithography for thick refractive optical elements in SU-8 (2003)

We have fabricated refractive optical elements in SU-8 resist using electron-beam lithography. Exposing an 8-μm-thick layer of SU-8 resist with a 30 kV electron beam, we demonstrate fabrication of an f/9 spherical lens, an f/2 spherical lens, and a prism with a 3° tilt. The elements all perform near the diffraction limit, with rms surface variations between 1/10 wave and 1/7 wave. The electron scattering from the thick resist is measured and shown to limit the technique to optical elements with relatively smooth surface figures.
The manufacture of a spring driven man's face shaver (1958)

Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1958.
Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation (2001)

In this study, self-organizing map (SOM) gene cluster techniques are applied to the analysis of cDNA microarray analysis of gene expression changes occurring in the early stages of genitourinary inflammation. We determined the time course of lipopolysaccharide (LPS)-induced gene expression in experimental cystitis. Mice were euthanized 0.5, 1, 4, and 24 h after LPS instillation into the urinary bladder, and gene expression was determined using four replicate Atlas mouse cDNA expression arrays containing 588 known genes at each time point. SOM gene cluster analysis, performed without preconditions, identified functionally significant gene clusters based on the kinetics of change in gene expression. Genes were classified as follows: 1) expressed at time 0; 2) early genes (peak expression between 0.5 and 1 h); and 3) late genes (peak expression between 4 and 24 h). One gene cluster maintained a constant level of expression during the entire time period studied. In contrast, LPS treatment downregulated the expression of some genes expressed at time 0, in a cluster including transcription factors, protooncogenes, apoptosis-related proteins (cysteine protease), intracellular kinases, and growth factors. Gene upregulation in response to LPS was observed as early as 0.5 h in a cluster including the interleukin-6 (IL-6) receptor, alpha- and beta-nerve growth factor (alpha- and beta-NGF), vascular endothelial growth factor receptor-1 (VEGF R1), C-C chemokine receptor, and P-selectin. Another tight cluster of genes with marked expression at 1 h after LPS and insignificant expression at all other time points studied included the protooncogenes c-Fos, Fos-B, Fra-2, Jun-B, Jun-D, and Egr-1. Almost all interleukin genes were upregulated as early as 1 h after stimulation with LPS. Nuclear factor-kappaB (NF-kappaB) pathway genes collected in a single cluster with a peak expression 4 h after LPS stimulation. In contrast, most of the interleukin receptors and chemokine receptors presented a late peak of expression 24 h after LPS coinciding with the peak of neutrophil infiltration into the bladder wall. Selected cDNA microarray observations were confirmed by RNase protection assay. In conclusion, the cDNA array experimental approach provided a global profile of gene expression changes in bladder tissue after stimulation with LPS. SOM techniques identified functionally significant gene clusters, providing a powerful technical basis for future analysis of mechanisms of bladder inflammation.
Femtosecond fiber-feedback OPO with 15.5 W average power based on periodically poled stoichiometric LiTaO3 (2003)

We demonstrate a synchronously pumped high-gain OPO with feedback through a fiber, using an Yb:YAG thin disk laser as pump source. We obtained 15.5 W average signal power at a wavelength of 1.45 µm in 630-fs pulses.
1 volt CMOS bluetooth front–end (2002)

A fully integrated 1 V CMOS Bluetooth front-end for low IF has been designed and measured. The front-end consists of a common-gate LNA and a passive mixer and fulfils the requirements of the Bluetooth specification 1.0B. The front-end has a maximum signal headroom in all nodes since no transistors are stacked, and no external components are needed for the input matching. The measurements show a very good correlation between different samples which indicates the robustness of the topology. The total power consumption is 2.5 mW, the noise figure is 5 dB, the conversion gain is 14 dB, the CP<sub>1</sub> is -16 dBm, and the IIP<sub>3</sub> is -5 dBm. The front-end is implemented in a standard 0.25 μm-CMOS technology
Mechanistic Modelling of Polymer Pyrolysis Using Monte Carlo Methods (1993)

Abstract Reaction modelling techniques using Monte Carlo Simulation are applied to the reactions of poly (arylether sulfones). We find that structure, reactions and diffusions may be described quantitatively in terms of a dynamic reaction lattice.
Microbes in Fuel: An Overview with a Naval Perspective (1988)

A brief review of the history of microbial contamination of distillate hydrocarbon fuels is followed by a discussion of the major fungal and bacterial genera responsible and the conditions necessary for their proliferation. Microorganisms cause problems because they promote corrosion, and their physical presence leads to plugging of coalescers, filters, and orifices and the malfunction of fuel system gages. Interactions among different microbial fuel contaminants may enhance or inhibit their growth, and simple changes in conditions in the aqueous medium, such as pH, might be exploited as a means of controlling microbial growth. New biocides are available that promise to control microbial fuel contaminants at very low concentrations and in the presence of fuel tank sludge.
Design and Preparation of a Novel Cross-Linkable, High Molecular Weight, and Bio-Based Elastomer by Emulsion Polymerization (2012)

A novel cross-linkable, high molecular weight poly(diisoamyl itaconate-co-isoprene) (PDII) elastomer was prepared by emulsion polymerization based on itaconic acid, isoamyl alcohol, and isoprene. Both persulfate and redox initiators were used for the copolymerization of diisoamyl itaconate and isoprene at different monomer ratios. Redox-initiated PDII has much higher molecular weight but relatively lower yield than the persulfate-initiated one. PDII with a number-average molecular weight of 352 000 and a glass transition temperature of −39.5 °C was obtained when the mass ratio of diisoamyl itaconate to isoprene was 80/20. Diisoamyl itaconate and isoprene reactivity ratios were determined by two conventional linear methods: the Fineman–Ross method and the Kelen–Tüdös method. Molecular dynamics simulation and FTIR were used to study the interaction between silica and PDII macromolecules, and the result showed that hydrogen bonds were formed between silica silanols and PDII macromolecules. Silica-reinforced PDII exhibited good mechanical performance, such as ultimate tensile strength above 11 MPa and elongation at break above 400%.