gebhart/patrepeval huggingface dataset:
Autoimmune-mediated Hypothyroidism in Systemic Lupus can be Normalized by Glucocorticoids and Hydroxychloroquine (2005)

Systemic lupus erythematosus (SLE) and autoimmune thyroid diseases are both marked by pathogenic autoantibodies. Autoimmune thyroid diseases have associated with a number of non-organ-specific rheumatological disorders, including SLE, Sjogren's syndrome, giant cell arteritis, and rheumatoid arthritis. Here, we reported three cases of hypothyroidism co-existed with SLE. In case Ⅰ, we noticed that corticosteroids or hydroxychloroquine may help to control autoimmune thyroid inflammation in SLE patients with hypothyroidism, and may turn abnormal thyroid function back to normal. In case Ⅱ, emergence of SLE in pre-existing hypothyroidism exacerbated the autoimmune condition with thyroid hypofunction and lupus activity. Oral thyroxine supplement gradually decreased to 0.05 mg qod one year after treatment for SLE. In case Ⅲ, hypothyroid function was diagnosed immediately before SLE. In addition, the transition of hyperthyroidism to hypothyroidism occurred in the medication of SLE with steroids and hydroxychloroquine. Unfortunately, we noted that along with the decreased dose of prednisolone, hypothyroidism seemed to be aggravated. 
Putting together, we suggest that corticosteroids and hydroxychloroquine for treating SLE activity are able to control thyroid inflammation and hypothyroid function. However, further investigation with a larger study is needed to confirm it.
High-Temperature Heat Capacity of Lanthanide Cuprates (2015)

This paper presents data on the heat capacity of lanthanide cuprates obtained in the temperature range 354 -877 K. The thermodynamic functions of the solid oxide compound have been calculated using the experimental data.
Dissection of a QTL Hotspot on Mouse Distal Chromosome 1 that Modulates Neurobehavioral Phenotypes and Gene Expression (2008)

A remarkably diverse set of traits maps to a region on mouse distal chromosome 1 (Chr 1) that corresponds to human Chr 1q21-q23. This region is highly enriched in quantitative trait loci (QTLs) that control neural and behavioral phenotypes, including motor behavior, escape latency, emotionality, seizure susceptibility (Szs1), and responses to ethanol, caffeine, pentobarbital, and haloperidol. This region also controls the expression of a remarkably large number of genes, including genes that are associated with some of the classical traits that map to distal Chr 1 (e.g., seizure susceptibility). Here, we ask whether this QTL-rich region on Chr 1 (Qrr1) consists of a single master locus or a mixture of linked, but functionally unrelated, QTLs. To answer this question and to evaluate candidate genes, we generated and analyzed several gene expression, haplotype, and sequence datasets. We exploited six complementary mouse crosses, and combed through 18 expression datasets to determine class membership of genes modulated by Qrr1. Qrr1 can be broadly divided into a proximal part (Qrr1p) and a distal part (Qrr1d), each associated with the expression of distinct subsets of genes. Qrr1d controls RNA metabolism and protein synthesis, including the expression of approximately 20 aminoacyl-tRNA synthetases. Qrr1d contains a tRNA cluster, and this is a functionally pertinent candidate for the tRNA synthetases. Rgs7 and Fmn2 are other strong candidates in Qrr1d. FMN2 protein has pronounced expression in neurons, including in the dendrites, and deletion of Fmn2 had a strong effect on the expression of few genes modulated by Qrr1d. Our analysis revealed a highly complex gene expression regulatory interval in Qrr1, composed of multiple loci modulating the expression of functionally cognate sets of genes.
Measurement of 16-μm emission of a two-photon-excited ammonia laser (1978)

The emission wavelengths at 16 μm of a two-photon-excited ammonia laser has been measured with improved accuracy. The measurement technique involves accurate calibration of the monochromator using well-known spectral lines and boxcar amplifiers to measure the total laser energy per laser pulse and the energy transmitted through the monochromator.
Human Pluripotent Stem Cell-Derived Cardiomyocytes: Response to TTX and Lidocain Reveals Strong Cell to Cell Variability (2012)

Stem cell derived cardiomyocytes generated either from human embryonic stem cells (hESC-CMs) or human induced pluripotent stem cells (hiPSC-CMs) hold great promise for the investigation of early developmental processes in human cardiomyogenesis and future cell replacement strategies. We have analyzed electrophysiological properties of hESC-CMs (HES2) and hiPSC-CMs, derived from reprogrammed adult foreskin fibroblasts that have previously been found to be highly similar in terms of gene expression. In contrast to the similarity found in the expression profile we found substantial differences in action potentials (APs) and sodium currents at late stage (day 60) of in vitro differentiation with higher sodium currents in hiPSC-CMs. Sensitivity to lidocain was considerably reduced in hESC-CMs as compared to hiPSC-CMs, and the effect could not be explained by differences in beating frequency. In contrast, sensitivity to tetrodotoxin (TTX) was higher in hESC-CMs suggesting different contributions of TTX-sensitive and TTX-resistant sodium channels to AP generation. These data point to physiological differences that are not necessarily detected by genomics. We conclude that novel pharmacological screening-assays using hiPSC-CMs need to be applied with some caution.
Antioxidant effect of flavonoids on DCF production in HL‐60 cells (2003)

A fluorometric microplate assay was performed for the detection of respiratory burst activity in a human leukaemia cell line HL-60 by assessing oxidation of 2',7'-dichloro fluorescin diacetate (DCFH-DA). This method is based on the detection of DCFH oxidation due to the presence of hydrogen peroxide. In the present study, the antioxidant activity of a number of structurally related flavonoids of plant origin and some of their microbial transformation products (1-18) were evaluated.
Ramp-rate limitation test of cable-in-conduit conductors with supercritical helium (1995)

It has been found on the United States Demonstration Poloidal Coil (US-DPC) and in 27 strand subsized cables of pool boiling cable-in-conduit conductor (CICC), that there is critical current degradation due to fast ramping of the magnetic field. The characteristics of this ramp-rate limitation phenomenon are investigated by using a 27 strand Nb/sub 3/Sn cable in supercritical helium at 6 atm. A 3 m long cable-in-conduit conductor is prepared noninductively and tested in a background field up to 9.5 tesla with maximum ramp rate of 1.6 tesla/second. The ramp-rate limitation results are compared with results of the ramp rate test of the US-DPC and previous experiments. The experimental data are analyzed to identify and understand possible sources of ramp-rate limitation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Eye position feedback in a model of the vestibulo-ocular reflex for spino-cerebellar ataxia 6 (2005)

The autosomal dominant spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases characterized by progressive instability of posture and gait, incoordination, ocular motor dysfunction, and dysarthria due to degeneration of cerebellar and brainstem neurons. Recent studies have established that there are more than 16 genetically distinct subtypes. Clinical observations suggest that eye movements and postural stability are universally but differentially impaired in the SCAs. The aim of the present work was to study the horizontal vestibulo-ocular reflex (VOR) in SCA6 patients to understand the pathophysiology of the VOR due to cerebellar Purkinje cell degeneration. The VOR was recorded in patients with genetically defined SCA6 during rotation in the dark. Severely affected subjects had an intact VOR, but there were quantitative differences in the gain and dynamics compared to normal controls. During angular velocity ramp rotations, there was a reversal in the direction of the VOR that was more pronounced in SCA6 compared to controls. Modeling studies indicate that abnormal feedback of an eye position signal into the velocity storage network can account for this reversal. These and other results will help to identify features that are diagnostic for SCA subtypes and provide new information about selective vulnerability of neurons controlling vestibular reflexes.
GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R (2015)

Obesity and diabetes are characterized by increased inflammation reflecting disordered control of innate immunity. We reveal a local intestinal intraepithelial lymphocyte (IEL)-GLP-1 receptor (GLP-1R) signaling network that controls mucosal immune responses. Glp1r expression was enriched in intestinal IEL preparations and copurified with markers of Tαβ and Tγδ IELs, the two main subsets of intestinal IELs. Exendin-4 increased cAMP accumulation in purified IELs and reduced the production of cytokines from activated IELs but not from splenocytes ex vivo. These actions were mimicked by forskolin, absent in IELs from Glp1r(-/-) mice, and attenuated by the GLP-1R agonist exendin (9-39) consistent with a GLP-1R-dependent mechanism of action. Furthermore, Glp1r(-/-) mice exhibited dysregulated intestinal gene expression, an abnormal representation of microbial species in feces, and enhanced sensitivity to intestinal injury following administration of dextran sodium sulfate. Bone marrow transplantation using wild-type C57BL/6 donors normalized expression of multiple genes regulating immune function and epithelial integrity in Glp1r(-/-) recipient mice, whereas acute exendin-4 administration robustly induced the expression of genes encoding cytokines and chemokines in normal and injured intestine. Taken together, these findings define a local enteroendocrine-IEL axis linking energy availability, host microbial responses, and mucosal integrity to the control of innate immunity.
An agent-based and market-oriented approach to distributed ISR resource allocation (2003)

Dominant trends in emerging Command, Control, Communications, Computers and Intelligence (C4I) systems include the widespread availability of global secure communications and open systems interoperability. These trends have encouraged information sharing through the decentralization of the distribution of Intelligence, Surveillance and Reconnaissance (ISR) assets and consumers. ISR producer and consumer relationships are now possible across previously closed geographic, system, and service boundaries. While access to ISR products and consumers has improved, little development has gone into global planning and control of ISR assets to suit this new open, distributed environment. We believe that Market-Oriented Programming (MOP) using a distributed agent-based architecture is a good control mechanism for optimally allocating resources for ISR tasks in this new environment. Agent technology will allow MOP to be encapsulated and distributed to ISR consumers and producers allowing for dynamic allocation and distribution of ISR resources. This paper describes a MOP solution to ISR management and an agent architecture used to implement it.
Comparison of Velocity- and Acceleration-Selective Arterial Spin Labeling with [<sup>15</sup>O]H<sub>2</sub>O Positron Emission Tomography (2015)

In the last decade spatially nonselective arterial spin labeling (SNS-ASL) methods such as velocity-selective ASL (VS-ASL) and acceleration-selective ASL have been introduced, which label spins based on their flow velocity or acceleration rather than spatial localization. Since labeling also occurs within the imaging plane, these methods suffer less from transit delay effects than traditional ASL methods. However, there is a need for validation of these techniques. In this study, a comparison was made between these SNS-ASL techniques with [(15)O]H2O positron emission tomography (PET), which is regarded as gold standard to measure quantitatively cerebral blood flow (CBF) in humans. In addition, the question of whether these techniques suffered from sensitivity to arterial cerebral blood volume (aCBV), as opposed to producing pure CBF contrast, was investigated. The results show high voxelwise intracranial correlation (0.72 to 0.89) between the spatial distribution of the perfusion signal from the SNS-ASL methods and the PET CBF maps. A similar gray matter (GM) CBF was measured by dual VS-ASL compared with PET (46.7 ± 4.1 versus 47.1 ± 6.5 mL/100 g/min, respectively). Finally, only minor contribution of aCBV patterns in GM to all SNS-ASL methods was found compared with pseudo-continuous ASL. In conclusion, VS-ASL provides a similar quantitative CBF, and all SNS-ASL methods provide qualitatively similar CBF maps as [(15)O]H2O PET.
Health Smart Home - Towards an assistant tool for automatic assessment of the dependence of elders (2007)

In order to help elders living alone to age in place independently and safely, it can be useful to have an assistant tool that can automatically assess their dependence and issue an alert if there is any loss of autonomy. The dependence can be assessed by the degree of performance, by the elders, of activities of daily living. This article presents an approach enabling the activity recognition for an elder living alone in a Health Smart Home equipped with noninvasive sensors.
3. Multiresolution Analysis (1997)

Both the short-time Fourier transform (STFT) and the integral wavelet transform (IWT), also known as continuous wavelet transform (CWT), are very useful time-frequency localization tools, provided that the lowpass window function ø(t) for the STFT and the bandpass window function ψ(t) for the IWT are suitably chosen and well localized, with not-so-large values of Δϕ Δ ϕ ^ <∞and Δψ Δ ψ ^ + <∞. In applying the IWT with ψ(t) as the analyzing wavelet to signal analysis, we first map the finite-energy analog signal into some signal space which is determined by a lowpass window function ø(t) with finite RMS bandwidth. For computational and implementational efficiency, this lowpass filter ø(t) must satisfy a two-scale relation. That is, ø(t) must be a scaling function. Such a scaling function generates a multiresolution analysis (MRA) of the space of finite-energy signals. In the first section of this chapter we describe how a finite-energy signal is represented as a signal in in terms of superpositions of translates of ø on a uniform sample set. The concept of stability of such signal representations will also be discussed in this section. A study of “scaling functions” to take care of nonuniform sample sets will be addressed in Chapter 6. Two very simple examples will be given in section 3.2: the first by applying the sampling theorem and the second by considering piecewise constant interpolation. These two examples will be used to motivate the notion of MRA in section 3.3, and the example of piecewise constant representation will also be generalized to the representation by cardinal splines in section 3.4, demonstrating the effectiveness of the MRA approach in signal representations and signal analysis. 3.1. Signal spaces with finite RMS bandwidth. It is well known that every bandlimited signal can be perfectly recovered from its discrete samples, provided that the sampling period is sufficiently small. This is a consequence of the sampling theorem, which can be stated as follows.
Relative reactivities of heteroaromatic cations toward ferricyanide ion oxidation (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRelative reactivities of heteroaromatic cations toward ferricyanide ion oxidationJohn W. Bunting and Dimitrios StefanidisCite this: J. Org. Chem. 1986, 51, 11, 2068–2071Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/jo00361a025https://doi.org/10.1021/jo00361a025research-articleACS PublicationsRequest reuse permissionsArticle Views191Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recombinant human C1‐inhibitor in the treatment of acute angioedema attacks (2007)

The transgenically produced rHuC1INH was successfully used in the treatment of acute angioedema attacks in patients with hereditary C1-inhibitor deficiency.
SUMMARY OF CREEP TESTS ON THE PIQUA OMR FLAT-PLATE FUEL ELEMENT (1959)

The Piqua OMR design specifies a 750 deg F maximum surface temperature for the Al cladding on the fuel plates. The possibility existed that fuel element failure might occur as a result of creep of the cladding which could obstruct the flow channels. Test fuel elements were suspended in circulating coolant for periods up to 718 hrs at temperatures to 800 deg F. No evidence of creep was found. (W.D.M.)
Microarray analysis of shear stressed endothelial cells (2003)

The cDNA microarray is an extremely beneficial tool for study of differential gene expression in the cardiovascular system. This technique is used in many different applications including drug discovery, environmental science, and the effects of mechanical forces on vascular cell phenotype. The paper reviews work by others, and describes our study on effects of shear stress on vascular endothelial cells. These microarray studies verified earlier findings using Northern and polymerase chain reaction (PCR) analyses in this area; and also found previously unidentified differentially expressed genes, leading to new hypotheses regarding how cells and tissues respond to biochemical and mechanical stimuli.
Recent Land-Use Changes in the San Francisco Bay Area (1957)

B ETWEEN 1940 and 1955 California's population climbed spectacularly, from 6,907,387 to an estimated 13,000,000, a growth of 88 per cent. The population of the San Francisco Bay Area increased at about the same rate, from 1,734,308 to about 3,200,000. An ample salt-water harbor with sea-level access to the Central Valley has given this area a gateway position, which has been an important factor in its growth and development. In the two decades between 1920 and 1940 metropolitan San FranciscoOakland remained the major center of population but new communities arose that later became nuclei for suburban growth. Interurban electric streetcar lines and railroads with commuter service traversed much of the area, with direct routes into San Francisco from the Peninsula to the south and with ferry connections north and east across the bay. The Southern Pacific railroad was primarily the reason for much growth on the bayside flatlands between San Francisco and San Jose. Shortly before 1940 the two transbay bridges, Golden Gate and San Francisco-Oakland Bay, brought new suburbs within easy commuting range, and shortly after World War II local freeway or expressway construction was begun, linking outlying suburbs even more directly to San Francisco and Oakland. These modern thoroughfares, built in an attempt to reduce travel time, resulted in a population expansion in the area tributary to the central cities and at the same time encouraged several subcenters to develop a semi-independent econoil-y. For example, San Jose, once primarily the market center of the productive orchards of the Santa Clara Valley and long the nation's leading fruit-canning center, formerly exported a large part of its surplus through the port of San Francisco; today the growth of diversified manufacturing has weakened San Jose's economic ties with that city. In spite of recent tendencies toward suburban development, the urban core of the Bay Area is still in San Francisco-Oakland-Berkeley, where six
PNS (Parabolized Navier-Stokes) Computations for Spinning and Fin-Stabilized Projectiles at Supersonic Velocities. (1985)

The Parabolized Navier-Stokes (PNS) computational technique has been applied to calculate the three-dimensional viscous flow about a standard spinning projectile and a long L/D finned projectile. The results for the spinning projectile are compared with past PNS computations and wind tunnel pressure and force measurements in order to benchmark the update version of the code. Excellent agreement is found and the improvements to the code are shown to provide greater computational efficiency. Results are then presented for the finned projectile configuration and comparison made with predictions from an inviscid code and values from a data base compiled from range firings. Keywords: Computational fluid dynamics; Finned projectiles; Three-dimensional flow; Supersonic viscous flow; Spinning projectiles.
Alanine Protects Liver From Injury Caused by D–Galactosamine and Ccl4 (1996)

The liver is the main organ involved in amino acid metabolism, and it utilizes glucogenic amino acids as substrates for glucose or adenosine triphosphate (ATP), but this process is impaired in clinical and experimental liver diseases. In this study, we administered high doses of amino acids in rats or cultured hepatocytes with experimental models of liver injury to examine whether such supplementation could attenuate liver damage. We found that the addition of alanine reduced enzyme leakage from primary cultured rat hepatocytes treated with D-galactosamine (D-gal), while other amino acids did not. A significant decrease of lactate dehydrogenase (LDH) leakage was observed when cells were cultured with >6 from mmol/L alanine. Alanine also reduced enzyme leakage from normal hepatocytes that were not treated with D-gal. In D-gal-treated rats, constant infusion of a high dose of alanine significantly reduced the plasma transaminase and total bilirubin levels when compared with infusion of an amino acid mixture. Bolus administration of alanine significantly prevented the elevation of plasma transaminase levels and histological liver damage in CCl4-treated rats, while fructose-1,6 bisphosphate (FDP) had little effect. Alanine might promote the restoration of damaged liver in hepatotoxicant-treated rats, because significant effect was found after the elevation in plasma transaminase levels. Alanine also prevented the decrease of cellular ATP caused by D-gal and appeared to promote ATP production in primary cultured rat hepatocytes. These results indicate that alanine reduces experimental liver damage by a direct effect on hepatocytes.
Morphology-dependent electric transport in textured ultrathin Al films grown on Si (2005)

The thickness and temperature dependence of the electrical resistivity of the (111) textured ultrathin aluminum metal films grown on (111) Si substrates using molecular-beam epitaxy have been investigated. For films with thickness &lt;50nm, the room-temperature value of resistivity—contrary to the predictions of existing theoretical models—is found to increase monotonically with thickness. In addition, the temperature dependence of these films exhibited a metal-to-insulator transition at ∼110K. The studies of films using atomic force microscopy, x-ray photoelectron spectroscopy, and x-ray diffraction revealed that the observed anomalous thickness and temperature dependence of resistivity arise due to the formation of two-dimensional network of Al islands, and the low-temperature electric transport of such films could be explained using variable range hopping conduction.