gebhart/patrepeval huggingface dataset:
The Impact of Epigenetic Modifications in Myeloid Malignancies (2021)

Myeloid malignancy is a broad term encapsulating myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Initial studies into genomic profiles of these diseases have shown 2000 somatic mutations prevalent across the spectrum of myeloid blood disorders. Epigenetic mutations are emerging as critical components of disease progression, with mutations in genes controlling chromatin regulation and methylation/acetylation status. Genes such as DNA methyltransferase 3A (<i>DNMT3A</i>), ten eleven translocation methylcytosine dioxygenase 2 (<i>TET2</i>), additional sex combs-like 1 (<i>ASXL1</i>), enhancer of zeste homolog 2 (<i>EZH2</i>) and isocitrate dehydrogenase 1/2 (<i>IDH1/2</i>) show functional impact in disease pathogenesis. In this review we discuss how current knowledge relating to disease progression, mutational profile and therapeutic potential is progressing and increasing understanding of myeloid malignancies.
Histocompatibility Antigens and Primary Open-Angle Glaucoma (1978)

Histocompatibility (HLA) antigen typing was performed on 306 patients who had been studied and classified carefully. Black individuals with primary open-angle glaucoma (POAG) had no significant differences in HLA antigen prevalences from black control subjects. In one white population with POAG, a significant decrease in HLA-A1, a significant increase in HLA-Aw31, and a significant increase in the antigen combination HLA-B7 and HLA-Bw22 were noted. However, these differences were not confirmed in a second white population with POAG. We concluded that associations between the A and B loci of the HLA antigen system and POAG were not as impressive as has been previously reported.
Synergistic induction of cardiomyocyte differentiation from human bone marrow mesenchymal stem cells by interleukin 1β and 5-azacytidine (2016)

Interleukin-1β (IL-1β) is a cytokine protein expressed by cardiomyocyte in myocardial damage-associated inflammation. Although several methods are currently available for treatment of heart diseases none of them are completely successful. Recently, stem cells have gained enormous attention and are expected to play a significant role for treating heart diseases. 5-Azacytidine (5-aza) has recently been found to cause stimulation of stem cells to differentiate into cardiomyocytes. Here we present the determination of whether IL-1β can induce the differentiation of mesenchymal stem cells (MSCs) to cardiomyocytes. MSCs were derived from bone marrow, propagated and then cultured in differentiation medium supplemented with 5-aza and IL-1β (at two levels, 5 and 10 ng/ml). After 21 days, total RNA was extracted and cDNA synthesis was carried out. Quantitative polymerase chain reaction (Q-PCR) was performed for detecting cardiac-specific markers. Besides, to investigate the expression of cardiac markers in protein levels, immunocytochemistry was done by specific antibodies. Ultimately, cardiac markers expression suggested that IL-1β and 5-aza synergistically induces the cardiomyocyte differentiation.
VHARP: Virtual Home Agent Reliability Protocol for Mobile IPv6 based Networks (2005)

Mobile IPv6 is an enabling platform for creating IP mobility in the evolution path towards next generation service offerings. Current specification of mobile IPv6 does not provide reliability in the network and there are other problems associated with it. In this paper, we introduce "virtual home agent reliability protocol" as a complete system architecture and extension to mobile IPv6 that supports reliability and offers solution to the reliability problems associated with mobile IPv6. We also present the results of several experiments to assess the performance of our solution. The main advantages of our protocol over other protocols are: reliable mobile IPv6 operation, transparent failure detection and recovery mechanisms, reduced message exchange, no service interruption in mobile applications, reduced workload, secure data transfer, improved overall system and application performance
Verification of Protein Structures: Side-Chain Planarity (1996)

Nine of the 20 natural amino acids contain a planar group in their side chains. For these groups, normal deviations from planarity were derived by the study of similar fragments in accurately determined small molecule structures. Comparison of these deviations with values found from a representative set of high-quality protein structures revealed that the planarity of the aromatic residues and arginine in protein structures is comparable to similar fragments in small molecules. For Asn, Gin, Asp and Glu, however, the deviations are up to twice as large as in comparable small-molecule structures, suggesting that adding an extra planarity restraint for these residue types could improve refinement procedures.
Numerical simulation of convective diffusion in blood flowing in a channel with a steady, three‐dimensional velocity field (1971)

Abstract A numerical study was performed to investigate improvement in mass transfer rates obtainable by introduction of secondary convection into a proposed membrane blood oxygenator. The three‐dimensional Navier‐Stokes equations were solved numerically for the velocity field in channel and the results used in the numerical solution for the local P o 2 in the oxygenator. The convective diffusion equation solved is nonlinear, in addition to being three‐dimensional, because of the presence of red cell oxygen sinks. The convection introduced was generated by moving one wall of the blood flow channel laterally to the main flow. Decreases in blood side film resistance up to 5 × 10 4 were predicted. In the presence of moderate to strong convection, the limiting factor on oxygenation rate is imposed by the membrane situated between blood and gas phases. It appears that a considerable decrease in required blood priming volume would be possible if the method discussed here were implemented.
A novel optical frequency-shift-keying transmitter based on polarization modulation (2005)

In this letter, we propose and experimentally demonstrate a novel optical frequency-shift-keying (OFSK) transmitter based on polarization modulation. It features data rate transparency and continuous tuning of wavelength spacing, providing great flexibility in OFSK transmitter design. The performance of the transmitter has been further experimentally characterized.
Humin based by-products from biomass processing as a potential carbonaceous source for synthesis gas production (2014)

Valorisation of humin by-products: the chemical structure of humin and the evolution as well as reactivity of humin in dry reforming.
Enzymic methods of resolving racemates of amino acids and their derivatives (1991)

The review is devoted to modern methods for resolving racemates of amino acids and their derivatives by the action of enzymes. Processes of enantioselective enzymic hydrolysis are considered for both C- (esters, amides, amino acid nitrites) and N-derivatives (acyl- and alkoxycarbonylamino acids) as well as for their cyclic derivatives. Examples are given of the catalytic preparation of optically active derivatives from racemic amino acids. The bibliography includes 119 references.
Hydroxyapatite Extracted from Waste Fish Bones and Scales via Calcination Method (2015)

A hydroxyapatite is known as one of vital materials and common use in biomedical field and concentrated in clinical area. In relation to the above, the development of hydroxyapatite powder becomes an attractive research lines due to simplify in produce it. Thus in this paper the researcher stress out about Hydroxyapatite powder gained from the natural sources or so called as the waste of Tilapia bone and scales. The raw bones of and scale were undergo to crushing process to form in powder size (0.2 mm) then analysed by X-ray Diffraction (XRD) to identified the mineralogy of raw bone. Moreover the powder of fish bone and scales also go through to Scanning Electron Microscope (SEM) machine to analyse the microstructure of the powder while EDS act as device to determine the chemical composition of the sample powder. Sample powder then forward calcination process at selected temperature range to as a cheaper method in obtained hydroxyapatite raw sources. The range of calcination temperatures are between 800°C to 1000 °C. The sample preparation were analysed in both condition before and after calcination process by using XRD, SEM and EDS. The HAP crystalline composition of tilapia bones for raw powder and at 800 °C are similar with HAP pattern (JDS 00-009-0432) and the chemical reaction is Ca 5 (PO4) 3 (OH) then at temperature 900 and 1000 similar to HAP pattern (JDS 00-055-0592) with chemical reaction equal to Ca 10 (PO4) 6 (OH) 2 .
Tubulin polyglycylation: a morphogenetic marker in ciliates (2000)

The occurrence of the tubulin post-translational modification, polyglycylation, in stable microtubular structures was investigated during morphogenesis in two ciliates, Paramecium and Frontonia atra, belonging to the Epiplasmata group. This analysis was carried out by means of immunofluorescence and post-embedding immunoelectron microscopy using two monoclonal antibodies, TAP 952 and AXO 49, respectively recognizing mono- and polyglycylated sites in alpha- and beta-tubulin. In the course of cell division, the TAP 952 epitope is detected in all microtubular structures including the newly assembled ones, such as cortical and oral basal bodies and cilia. In contrast, the AXO 49 epitope is only present in 'old' microtubular structures such as parental cortical and oral basal bodies and cilia. Our observations show that, in ciliates: 1) this tubulin post-translational modification takes place early in the course of morphogenesis; and 2) the lengthening of the polyglycine chains occurs after a great delay following addition of the first glycine residues on the tubulin glycylation sites, and following microtubule assembly. Thus, a sequential mechanism of polyglycylation is shown to take place in the tubulin molecule and during morphogenesis in Paramecium and Frontonia atra. Accordingly, polyglycylation, through a time-dependent polyglycine chain elongation process, appears to be a morphogenetic marker in ciliates.
Measurement of chloride-ion concentration with long-period grating technology (2007)

A simple and low-cost long-period fiber grating (LPG) sensor suited for chloride-ion concentration measurement is presented. The LPG sensor is found to be sensitive to the refractive index of the medium around the cladding surface of the sensing grating, thus offering the prospect of development of practical sensors such as an ambient index sensor or a chemical concentration indicator with high stability and reliability. We measured chloride ions in a typical concrete sample immersed in salt water solutions with different weight concentrations ranging from 0% to 25%. Results show that the LPG sensor exhibited a linear decrease in the transmission loss and resonance wavelength shift when the concentration increased. The measurement accuracy for the concentration of salt in water solution is estimated to be 0.6% and the limit of detection for chloride ions is about 0.04%. To further enhance its sensitivity for chloride concentrations, we coated a monolayer of colloidal gold nanoparticles as the active material on the grating surface of the LPG sensor. The operating principle of sensing is based on the sensitivity of localized surface plasmon resonance of self-assembled gold colloids on the grating section of the LPG. With this method, a factor of two increase in the sensitivity of detecting chemical solution concentrations was obtained. The advantages of this type of fiber-optic sensor are that it is compact, relatively simple to construct and easy to use. Moreover, the sensor has the potential capability for on-site, in vivo and remote sensing, and it has potential use as a disposable sensor.
The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue (1997)

To find out whether the composition of the subcutaneous adipose tissue of cats reflects the intake of polyunsaturated fatty acids, we performed a feeding trial. Six groups of kittens were fed on diets with variable combinations of corn, linseed, and fish oil. After 5 months, biopsies of subcutaneous adipose tissue were analysed for their contents of linoleic, alpha-linolenic, eicosapentaenoic, and docosahexaenoic acid. The observed strong correlations between dietary and fat tissue polyunsaturated fatty acids indicate that the fatty acid composition of adipose tissue may be used as an index of the fatty acid composition of the diet. Thus, in epidemiological studies on the possible relationship between dietary fat type and feline disease the fatty acid composition of adipose tissue might be a useful measure.
Cancer Stem Cells and Sonic Hedgehog Signaling in Head and Neck Cancer: Potential Targets for Overcoming Chemoradiation Resistance (2009)

Cancer stem cells (CSC) are a small and distinct population of cancer cells that possess self-renewal and differentiation ability and are relatively resistant to treatment including chemotherapy and radiotherapy. Sonic hedgehog (SHH) and related signaling molecules are critical to embryonic development and regulate both proliferation and differentiation of various types of stem cells, including CSC. This article provides a brief overview of the SHH signaling pathway, summarizes the correlation between SHH signaling and treatment resistance of cancer cells and discusses the recent advances in targeting this signaling cascade to overcome treatment resistance. We proposed that CSC and their related the SHH signaling pathway might be potential targets for overcoming chemoradiation resistance of head and neck cancer cells. This has been under investigation by our comprehensive team treating head and neck cancers.
Semi-random construction of quasi-cyclic LDPC codes (2005)

This paper presents a semi-random construction of quasi-cyclic LDPC codes, namely, the base incidence vectors are generated by computer search, and then the remainder incidence vectors are obtained by cyclically shifting these base incidence vectors. It is more flexible to construct QC-LDPC than pure geometric or algebraic methods. The simulation results demonstrate that QC-LDPC codes based on this method work quite well.
Random Access (2011)

In this chapter, the main roles of the Long Term Evolution (LTE) Random Access CHannel (RACH) are elaborated, together with its differences from the Wideband Code Division Multiple Access (WCDMA) RACH. The rationale for the design of the LTE Physical Random Access CHannel (PRACH) is explained, and some possible implementation options are discussed for both the User Equipment (UE) and the eNodeB. The random access preamble part of the random access procedure is mapped at the physical layer onto the PRACH. The design of the preamble is crucial to the success of the RACH procedure. The chapter provides some general principles for practical implementation of the PRACH function. Design principle of LTE is to maximize the commonality of Frequency Division Duplex (FDD) and Time Division Duplex (TDD) transmission modes. Controlled Vocabulary Terms long term evolution; multiaccess communication
Tissue responses in the rat to trichloracetic acid ‐ an agent used in the treatment of invasive cervical resorption* (1988)

Abstract The tissue responses in rats following topical application of 90 per cent trichloracetic acid to the palatal mucosa, and to a wound involving periodontal tissues, tooth root and bone were histologically evaluated. Coagulation necrosis of palatal and gingival mucosa was followed by oedema, splitting and separation of the eschar with rapid re‐epithelialization within two days. Of significance was an almost complete absence of underlying inflammation. There were no essential differences in the healing of the trichloracetic acid‐treated wounds into deeper dental tissues compared with control wounds. These results have significance with regard to the clinical use of trichloracetic acid in the treatment of invasive cervical resorption.
Routing Topology Identification Based on Multiple Sources End-to-End Measurements (2010)

This paper focuses on the multiple source, multiple destination network tomography problem. The main contributions are as follows. First, the performance stable delay difference measured by the back-to-back packet pair with different size is used firstly as path metrics to identify the topology. Second, this paper proposes a novel probing meathead to infer the hop count of the shared path for each 1-by-2 component and each 2-by-1 component. Third, with the novel methodology, we firstly resolve the key problem of routing topology identification by multiple sources network tomography. The accuracy and efficiency of methodology is validated by the simulation results.
European integration and national executives: A cause in search of an effect? (2000)

(2000). European integration and national executives: A cause in search of an effect? West European Politics: Vol. 23, Europeanised Politics? European Integration and National Political Systems, pp. 211-231.
[Duplication of a synthetic gene for human leukocyte interferon and its expression in polycistron mRNA with coupled translation system]. (1987)

Using a chemically synthesised adapter, the coding part of an artificial gene for human leukocyte alpha 2 interferon (ifn-alpha 2) has been duplicated. The adapter contained a termination signal of the first gene (TAA) within the Shine-Dalgarno sequence of the second gene (TAAGGA), distance between the terminating codon and starting codon of the second gene being 11 nucleotides. In another case this distance was 69 nucleotides, with the same SD sequence. The expression of the tandems as a part of polycistrons has been studied under control of promoters Plac, (Ptrp)2 of E. coli, and PVIII of M13 phage. It was found that tandems of ifn-alpha 2 genes in polycistronic structures trp L-ifn-ifn and IX-VIII-ifn-ifn under control of promoters (Ptrp)2 and PVIII, respectively, provided high level of the interferon biosynthesis, thus differing from the tandem under Plac promoter control, which had only ifn-ifn translation coupling.
The Measurement and Instantaneous Display of Bubble-Size Distribution, Using Scattered Light (1972)

The need for an instrument that measures the bubble distribution in a flow is well documented by the numerous studies that are conducted on cavitation inception and cavitation damage to materials. The present measurement techniques do not provide a complete solution to these problems. In this short paper, we have developed an instrument that determines the bubble-size distribution by measuring the intensity of light scattered from the bubbles. Bubbles in the range of 0.005 to 0.04 in in diameter were measured with this method. The lower limit of this range can be extended by decreasing the factors that contribute noise to the measurement.
Three Newly Approved Analgesics: An Update (2013)

Abstract Since 2008, three new analgesic entities, tapentadol immediate release (Nucynta) diclofenac potassium soft gelatin capsules (Zipsor), and bupivacaine liposome injectable suspension (EXPAREL) were granted US Food and Drug Administration (FDA) approval to treat acute pain. Tapentadol immediate-release is a both a mu-opioid agonist and a norepinephrine reuptake inhibitor, and is indicated for the treatment of moderate to severe pain. Diclofenac potassium soft gelatin capsules are a novel formulation of diclofenac potassium, which is a nonsteroidal anti-inflammatory drug (NSAID), and its putative mechanism of action is through inhibition of cyclooxygenase enzymes. This novel formulation of diclofenac allows for improved absorption at lower doses. Liposomal bupivacaine is a new formulation of bupivacaine intended for single-dose infiltration at the surgical site for postoperative analgesia. Bupivacaine is slowly released from this liposomal vehicle and can provide prolonged analgesia at the surgical site. By utilizing NSAIDs and local anesthetics to decrease the transmission of afferent pain signals, less opioid analgesics are needed to achieve analgesia. Since drug-related adverse events are frequently dose related, lower doses from different drug classes may be employed to reduce the incidence of adverse effects, while producing synergistic analgesia as part of a multimodal analgesic approach to acute pain.
Restructuring networks to avoid deadlocks in parallel simulations (1990)

The authors introduce a novel approach for parallel discrete event simulation which reduces or eliminates the possibility of deadlock without complex time synchronization or deadlock detection protocols. Deadlock is eliminated by restructuring the logical network representing the physical system to an equivalent network which is deadlock free. For large networks, a full elimination of deadlock can concentrate messages too much, so an intermediate restructuring is used to reduce and control the possibilities of deadlock. Empirical studies show that small to medium size queueing networks for which previous conservative methods have failed can be simulated in parallel with efficiencies ranging from 30 to 80%. >
외상성 두부 손상 아동의 인지기능 특성 및 어머니의 양육스트레스에 관한 예비연구 (2012)

본 연구의 목적은 외상성 두부 손상 아동의 인지 기능과 양육스트레스에 대한 임상적 특성을 파악 하는 것이었다. 이를 위해 한국판 웩슬러 아동용 지능검사, Rey-Kim 아동용 기억검사, 전산화된 주의력장애 진단 시스템(시각), 한국판 부모양육 스트레스검사를 사용하였다. 서울소재 대학병원에 외 상성 두부 손상을 주호소로 내원한 만 6세에서 15세에 해당하는 아동 중 심리평가에 의뢰된 아동 66명과 보호자 66명을 대상으로 자료를 수집하여 분석한 결과, 두부 손상으로 내원한 아동의 지능 평균은 평균 수준에 해당하였고, 기억 능력 평균은 평균하 상단 수준에 해당하고 있어 지능수준에 비해 통계학적으로 유의미한 수준의 저하가 시사되었다. 주의력의 경우 부주의, 충동성, 반응시간 표준편차의 영역의 평균 자체가 비정상 범위에 속하고 있으며, 과반수이상이 비정상 범위에 포함 되는 것으로 나타났다. 의식 소실의 유무로 집단을 나누어 비교해본 결과 의식 소실 경험의 아동은 전체 지능 및 동작성 지능에서 유의미한 저하를 보였으나 기타 영역에서는 두 집단의 차이가 나타나지 않았다. 어머니의 양육 스트레스 검사 결과 과반수이상이 정상 범위를 벗어나는 스트레스에 해당하고 있어 임상적으로 도움이 필요한 스트레스를 경험하고 있는 것으로 나타났다. 하위 영역 중 양육 유능감, 아동에 대한 기대, 자녀와의 애착, 역할의 제한의 영역에서 상대적으로 증가된 스트레스를 보이고 있었다. 의식 소실의 여부에 따라서는 통계적으로 의미 있는 차이를 보이지는 않았다. 이러한 두부 손상 아동들의 특성을 고려하여, 의학적 서비스와 더불어 학습 치료적 개입, 부모교육 프로그램 등과 같은 심리학적 서비스의 통합적 개입 계획 수립이 필요함이 시사되었다.
Equalization of Loudspeaker Drive Units Considering Both On- and Off-Axis Responses (1991)

Digital filters designed to equalize individual loudspeaker drive units are described. Results from computer simulation and measurement of a real-time implementation are presented
EFFECTS OF GABEXATE MESILATE (FOY), A NEW SYNTHETIC SERINE PROTEASE INHIBITOR, ON BLOOD COAGULATION IN PATIENTS WITH DIC (1987)

A pilot open controlled study of FOY was performed in 20 intensive care patients (pts, age 18-63) with DIC diagnosed with standard laboratory criteria (at least 3 of the following: Normotest 70%, fibrinogen 150 mg%, AT III 80%, FDP 20 ug/ml, platelets 150000). Besides the usual treatments, FOY was given to 10 pts (FOY G.) by continuous i.v. infusion (1mg/kg/h) for up to 7 days, while in 10 control pts (Hep.G.) the treatment included low dose s.c. heparin. Blood clotting tests were performed at admission to the study and daily for 7 days; we consider here results obtained at baseline and at the 4th (7 survivors in FOY G. and 10 in Hep.G.) and the 7th day (6 surv. in FOY G. and 9 in Hep. G.). Statistical evaluation was made by means of the twotailed Wilcoxon test for non parametric paired data. In the FOY G. depressed baseline AT III and plasminogen (Plgn) activities (61.8+/-5.3% and 57+/-5.5% respectively) significantly increased at 4th day (92+/-11.2% and 83+/-3.1% p<0.05), Plgn furtherly significantly increased at 7th d. (p<0.05). In the Hep.G. Normotest, Plgn and Platelets significantly (p<0.05) increased at 4th day, but no changes in AT III were found. Fibrinogen increased in both groups during the observation period (pA0.05). Serum and especially "plasma" FDP (specific monoclonal Ab to fgn and fibrin degradation products), as well as D-Dirner and HMW fgn complexes measured by exclusion chromatography, decreased especially in the FOY G. These results show that FOY modifies the clotting laboratory pattern in DIC pts, likely by an antithrombin effect. The clinical significance of these effects remains, however, to be explored.