gebhart/patrepeval huggingface dataset:
Pharmacokinetics of radiopharmaceuticals. (1992)

The pharmacokinetics of various radiopharmaceuticals following i.v. administration in mice and rats has been studied and compared. Before injection the radiochemical purity (RP) of the compounds were determined by HPLC and PAGE. In all cases RP-s were higher than 90%. The biodistribution of 99mTc labelled anti CEA IgG was studied in mice bearing human colon carcinoma xenografts. Animals with different tumour weights showed different blood kinetic and tumor uptake. The pilot clinical study of the 99mTc labelled anti melanoma Fab and 111-In-DTPA labelled anti melanoma F(ab')2 showed differences in the pharmacokinetic parameters. (99mTc labelled: comp.A. 84.6%; T1/2:0.6 h, 111-In-labelled: comp.A.: 46%, T1/2 1.5 h.) The various isonitrile derivatives synthetized in our laboratory were labelled with 99mTc and the biodistribution were tested in rats. The kinetic study showed that all the three molecules have different half lives in the heart and liver (T1/2 for heart ranged 5.1-18.6 h, for liver T1/2:1.2-2.5 h). Reversed phase HPLC study of the collected bile showed the 15-100% of injected compounds are metabolized during hepatic excretion. Literature data and our recent observations confirm that the knowledge of pharmacokinetics of radiolabelled compounds both in research, development and clinical practice is of basic importance.
Comparing Two Methods for Estimating Network Size (2001)

In this paper we compare two methods for estimating the size of personal networks using a nationally representative sample of the United States. Both methods rely on the ability of respondents to estimate the number of people they know in specific subpopulations of the U.S. (e.g., diabetics, Native Americans) and people in particular relation categories (e.g., immediate family, coworkers). The results demonstrate a remarkable similarity between the average network size generated by both methods (approximately 291). Similar results were obtained with a separate national sample. An attempt to corroborate our estimates by replication among a population we suspect has large networks (clergy), yielded a larger average network size. Extensive investigation into the existence of response effects showed some preference for using certain numbers when making estimates, but nothing that would significantly affect the estimate of network size beyond about 6 percent. We conclude that both methods for estimating personal network size yield valid and reliable proxies for actual network size, but questions about accuracy remain.
Effects of distance and barriers between resources on bone and tendon strength and productive performance of broiler chickens (2014)

Lameness or leg weakness is becoming an important problem in broilers selected for rapid growth, and although the causes are not known, sedentary behavior could be a cause. Two experiments were conducted to study the effects of distance and the presence of ramps between resources (feed and water) on bone and tendon strength, ability to stand, and productive performance. In experiment 1, straight run Ross 708 chicks (n = 1,260) were randomly assigned to 1 of 3 treatments: 1.0, 3.3, or 6.6 m between resources (6 pen replicates/treatment). In experiment 2, Cobb 500 male chicks (n = 864) were randomly assigned to 1 of 4 treatments (2 × 2 factorial, 4 pen replications/treatment) consisting of 2 distances (3 or 8 m) with (WR) or without (NR) a ramp (a triangular prism 31 cm high and 132 cm wide at the base). At d 21, 45, and 56 (experiment 1), or at d 28, 35, 42, and 49 (experiment 2), birds were weighed, killed, and tibias collected to measure breaking strength (BBS), and abdominal fat (AbF) content. At d 49 (experiment 2), calcaneus tendons were also collected to measure breaking strength (TBS). Foot pad lesions and latency to lie (LTL) were determined before killing the birds. In experiment 1, distance did not affect BBS, LTL, foot pad lesions, or BW, but at d 49, birds in the 6.6 m treatment had lower AbF than birds in the other treatments. In experiment 2 at d 49, birds in the 8 m treatment tended to have a higher BBS than birds in the 3 m treatment (P = 0.09), whereas WR birds had lower tendon breaking strength than NR birds (P < 0.01); however, LTL was highest in 8-m NR birds. Final BW was not affected by distance, but birds in the NR group were heavier than birds in the WR group. Furthermore, AbF was lower in 8 m than in 3 m birds. Our results suggest that longer distances between resources have limited effects on bone strength, but increase the LTL, and may change feeding patterns and carcass characteristics, as evidenced by the lower AbF content. Ramps or inclination affected tendon breaking strength.
Modeling and Simulation of Discretized Data Transmission in Very High-Speed Digital Subscriber Line (2002)

We implement a Synchronous Dataflow (SDF) model for the discretized data transmission in Very High-Speed Digital Subscriber Line (VDSL) using Agilent Advanced Design System (ADS) electronic design automation software. Our ADS implementation will enable designers to simulate and optimize different VDSL transceiver designs. The filters used at the VDSL receiver and the bit allocations for sub-channels of a specific VDSL channel are designed using MATLAB and are integrated into our ADS implementation. The overall ADS implementation of the system is fully compliant with the performance requirements of the European Telecommunication Standards Institute VDSL specification.
Access-Authorizing and Privacy-Preserving Auditing with Group Dynamic for Shared Cloud Data (2016)

Cloud storage is becoming more and more popular because of its elasticity and pay-as-you-go storage service manner. In some cloud storage scenarios, the data that are stored in the cloud may be shared by a group of users. To verify the integrity of cloud data in this kind of applications, many auditing schemes for shared cloud data have been proposed. However, all of these schemes do not consider the access authorization problem for users, which makes the revoked users still able to access the shared cloud data belonging to the group. In order to deal with this problem, we propose a novel public auditing scheme for shared cloud data in this paper. Different from previous work, in our scheme, the user in a group cannot any longer access the shared cloud data belonging to this group once this user is revoked. In addition, we propose a new random masking technique to make our scheme preserve both data privacy and identity privacy. Furthermore, our scheme supports to enroll a new user in a group and revoke an old user from a group. We analyze the security of the proposed scheme and justify its performance by concrete implementations.
Description of the demonstration of European testing equipment for hot mix asphalt pavement (1992)

The Colorado Department of Transportation (CDOT) and the Turner-Fairbank Highway Research Center (TFHRC) will be demonstrating some European testing equipment for hot mix asphalt. The equipment includes the French mixer, French gyratory compactor, French plate compactor, Hamburg wheel tracking device and the Georgia loaded wheel tester. The advantages, disadvantages, costs and manufacturers are discussed. The joint research project between CDOT and TFHRC to evaluate the equipment and asphalt mixes is included.
<i>In Situ</i> Studies of Coatings on Metal Wires by FT-IR External Reflectance Spectroscopy (1987)

Diffuse reflectance FT-IR spectroscopy was originally developed for particulate samples dispersed in KBr powders. Now, by using ellipsoid mirrors for scattered light collection, we have taken advantage of the collection efficiency of diffuse reflectance optics and have extended their use to an in situ study of coatings on metal wires and of the broken surface of a reinforcement wire as well. The result is that spectra of coatings on wire show good overall agreement with external reflection spectra of thin films. The technique we have developed has an advantage over infrared attenuated total reflection (ATR), in that there is no optical contact problem between the wire sample and ATR crystal.
Genomic Prediction of Breeding Values when Modeling Genotype × Environment Interaction using Pedigree and Dense Molecular Markers (2012)

ABSTRACT Genomic selection (GS) has become an important aid in plant and animal breeding. Multienvironment (multitrait) models allow borrowing of information across environments (traits), which could enhance prediction accuracy. This study presents multienvironment (multitrait) models for GS and compares the predictive accuracy of these models with: (i) multienvironment analysis without pedigree and marker information, and (ii) multienvironment pedigree or/and marker‐based models. A statistical framework for incorporating pedigree and molecular marker information in models for multienvironment data is described and applied to data that originate from wheat ( Triticum aestivum L.) multienvironment trials. Two prediction problems relevant to plant breeders are considered: (CV1) predicting the performance of untested genotypes (“newly” developed lines), and (CV2) predicting the performance of genotypes that have been evaluated in some environments but not in others. Results confirmed the superiority of models using both marker and pedigree information over those based on pedigree information only. Models with pedigree and/or markers had better predictive accuracy than simple linear mixed models that do not include either of these two sources of information. We concluded that the evaluation of such trials can benefit greatly from using multienvironment GS models.
ÍNDICES DE HEMATÓCRITO E ERITROPOETINA EM CICLISTAS E SEDENTÁRIOS (2014)

Devido os ciclistas necessitarem de um alto aporte de oxigenio para a realizacao de uma competicao eficaz o presente estudo objetivou avaliar se os indices de hematocrito e eritropoetina aumentam com a pratica de exercicio fisico como o ciclismo, em relacao a pessoas sedentarias. O estudo foi submetido e aprovado pelo comite de etica em pesquisa da Faculdade Redentor em Itaperuna. Os participantes da pesquisa apresentaram faixa etaria variando entre 23 a 54 anos, assinaram um termo de consentimento livre e esclarecido, preencheram um questionario e em seguida foi realizado a puncao venosa e retirada de 5mL de sangue antes e imediatamente apos a competicao. Os resultados indicam que nao houve diferenca estatistica dos resultados de hematocrito entre sedentarios (42,33/±2,72) e ciclistas pre (43,33/±2,29) e entre este ultimo e ciclistas pos (43,00/±1,91) para p ≤ 0,05. Os resultados referentes a eritropoetina tambem nao se mostraram significativos entre o grupo sedentario (7,28/±2,49) e ciclistas pre (9,44/±4,37)  e entre este ultimo comparado aos ciclistas pos (8,95/±3,73). Entretanto, a serie branca mostrou-se alterada apos a competicao. Logo, conclui-se que o tempo de coleta nao possibilitou averiguar diferencas significativas das variaveis entre os grupos estudados.
Novel Systems Modeling Methodology in Comparative Microbial Metabolomics: Identifying Key Enzymes and Metabolites Implicated in Autism Spectrum Disorders (2015)

Autism spectrum disorders are a group of mental illnesses highly correlated with gastrointestinal dysfunction. Recent studies have shown that there may be one or more microbial "fingerprints" in terms of the composition characterizing individuals with autism, which could be used for diagnostic purposes. This paper proposes a computational approach whereby metagenomes characteristic of "healthy" and autistic individuals are artificially constructed via genomic information, analyzed for the enzymes coded within, and then these enzymes are compared in detail. This is a text mining application. A custom-designed online application was built and used for the comparative metabolomics study and made publically available. Several of the enzyme-catalyzing reactions involved with the amino acid glutamate were curiously missing from the "autism" microbiome and were coded within almost every organism included in the "control" microbiome. Interestingly, there exists a leading hypothesis regarding autism and glutamate involving a neurological excitation/inhibition imbalance; but the association with this study is unclear. The results included data on the transsulfuration and transmethylation pathways, involved with oxidative stress, also of importance to autism. The results from this study are in alignment with leading hypotheses in the field, which is impressive, considering the purely in silico nature of this study. The present study provides new insight into the complex metabolic interactions underlying autism, and this novel methodology has potential to be useful for developing new hypotheses. However, limitations include sparse genome data availability and conflicting literature experimental data. We believe our software tool and methodology has potential for having great utility as data become more available, comprehensive and reliable.
LA ALTURA DE LOS FAROS DE ÉPOCA ROMANA EN RELACIÓN CON SU VISIBILIDAD MARÍTIMA: EL FARO DE BRIGANTIUM Y EL POSIBLE FARO DE LA CAMPA TORRES (GIJÓN) (2012)

Aunque son muy escasos los restos arqueológicos de faros costeros de época romana documentados hasta la fecha, parece que, al menos en la zona entre el Cantábrico y el sur de Inglaterra, existían dos categorías de faros en función de sus dimensiones. Se ha planteado el interrogante de si esta dualidad edilicia se debía a causas objetivas (como la importancia del puerto para el Estado romano o las dificultades particulares de la visibilidad del faro), o si por el contrario respondía a diferentes soluciones constructivas propuestas por el arquitecto de la obra (Fernández Ochoa, Morillo, 2009:132).En este trabajo, a través del estudio de dos de los casos de Hispania (el faro de Brigantium, conocido como Torre de Hércules, y el posible faro de la Campa Torres), pretendemos mediante procedimientos SIG arrojar luz sobre la cuestión de si las dimensiones de los faros estaban o no relacionadas con aspectos particulares de su visibilidad desde el mar.Palabras clave: faros romanos, visibilidad, SIGSummaryVery few archaeological remains of Roman coastal lighthouses have been documented to date. However, in respect to building height, it seems that there were two groups of lighthouses in Northern Spain, France and Southern England. C. Fernández Ochoa and A. Morillo recently raised the question of whether this fact was due to Roman State decisions, to visibility practice or to particularities of every building works (Fernández Ochoa, Morillo, 2009:132).This paper deals with Roman lighthouses height related to visibility. The aim is to assess if visibility practice was the main reason to set lighthouses height. GIS viewshed analysis has been applied to the lighthouse of Brigantium (A Coruña, Spain) and to the hypothetical lighthouse of La Campa Torres (Gijón, Spain).Keywords: Roman lighthouses, viewshed, GIS.
Models for heteropoly blues. Degrees of valence trapping in vanadium(IV)- and molybdenum(V)-substituted Keggin anions (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModels for heteropoly blues. Degrees of valence trapping in vanadium(IV)- and molybdenum(V)-substituted Keggin anionsJulianne J. Altenau, Michael T. Pope, Ronald A. Prados, and Hyunsoo. SoCite this: Inorg. Chem. 1975, 14, 2, 417–421Publication Date (Print):February 1, 1975Publication History Published online1 May 2002Published inissue 1 February 1975https://pubs.acs.org/doi/10.1021/ic50144a042https://doi.org/10.1021/ic50144a042research-articleACS PublicationsRequest reuse permissionsArticle Views1342Altmetric-Citations188LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Presence of  -Interferon in Human Amniotic Fluid (1982)

Almost all the samples of amniotic fluid from 62 pregnant women from the 16th week to the end of the pregnancy contained detectable amounts of alpha-type interferon. The presence of this substance in amniotic fluid during pregnancy raises the question of the physiological significance of this finding. It is postulated that the amniotic type of alpha-interferon might be a product of a constitutive gene, rather than induced by latent virus infection.
Veiligheid en volkenrecht: van mondiale naar regionale collectieve veiligheid (1996)

De Verenigde Naties
A Mobile Multistage 3000-cfm Pumping System (1972)

A trailer-mounted two-stage booster mechanical pumping system has been constructed for use in evacuation of large vacuum vessels in remote locations. The pumping system is composed of three nominal 1500-cm air-cooled Roots blowers and four nominal 150-cfm mechanical pumps. It includes a high conductance cryogenic baffle, a self-contained helium leak detection station with a high speed oil diffusion pump, a liquid cryogenic system for supply of cryogenic fluids to the two cryogenic traps, and dry gas for use in backfilling of vessels as required. A programmed start-up and run-down control is provided for simplified, safe operation of the pumping system. A simplified method of presenting pumping system performance and a design analysis procedure for matching of mechanical pumps to the boosters are described.
Failure of Dehydroepiandrosterone to Influence Energy and Protein Metabolism in Humans* (1990)

It was reported recently that 4 weeks of dehydroepiandrosterone (DHEA) treatment [5.55 mmol/day (1600 mg/day), orally] reduced body fat and increased lean body mass in healthy men. The present study was performed to examine whether these effects could be explained by increased energy expenditure and muscle protein synthesis. Eight healthy men were given placebo and DHEA (1600 mg/day) for 4 weeks each in a double blind cross-over study. DHEA treatment caused a 9-fold increase in mean plasma DHEA sulfate concentrations, but had no significant effect on body weight or on two indices of lean body mass (total body water and total body potassium). DHEA had no effect on any of the parameters of energy and protein metabolism, including resting metabolic rate, total energy expenditure (estimated by the 2H2(18)O method during the final 2 weeks of each treatment period), leucine flux (an index of whole body proteolysis), the nonoxidized portion of leucine flux (an index of whole body protein synthesis), and the rate of incorporation of leucine into muscle protein. Circulating levels of cholesterol, T3, and T4 also were unaffected by DHEA. These data suggest that DHEA is not an important regulator of energy or protein metabolism in humans.
miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia (2017)

Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of miR-92a in acute myeloid leukemia (AML) remain to be elucidated. Our data showed that miR-92a was evidently downregulated and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was remarkably upregulated in AML cell lines HL-60 and THP-1. Dual luciferase reporter assay revealed that MTHFD2 was a direct target of miR-92a. Gain- and loss-of-function analysis demonstrated that MTHFD2 knockdown or miR-92a overexpression notably inhibited proliferation and promoted apoptosis of AML cell lines. Restoration of MTHFD2 expression reversed proliferation inhibition and apoptosis induction of AML cells triggered by miR-92a. Moreover, an implanted tumor model in mice indicated that miR-92a overexpression dramatically decreased tumor growth and MTHFD2 expression in vivo. Taken together, our results suggest that miR-92a inhibits proliferation and induces apoptosis by directly regulating MTHFD2 expression in AML. miR-92a may act as a tumor suppressor in AML, providing a promising therapeutic target for AML patients.
Investigation of the release reaction in platelets exposed to phorbol myristate acetate. (1974)

Phorbol myristate acetate (PMA), the active principle of croton oil, is a potent platelet aggregating agent. Previous cytochemical and electron microscopic studies demonstrated that PMA caused selective labilization of platelet storage granules resulting in their conversion to distended vacuoles. Communication was established between the enlarged, almost empty vacuoles and the surrounding plasma through channels of the open canalicular system. The present study has explored the possibility that the effect of PMA on platelet storage organelles stimulates a process of secretion. Analysis of the release reaction in platelets after exposure to PMA revealed that significant amounts of serotonin and adenine nucleotides were secreted without loss of lactic dehydrogenase. Release took place well before the onset of irreversible aggregation. Inhibitors of platelet secretion or ADP induced aggregation could modify or prevent the irreversible clumping stimulated by small concentrations of PMA. Although the secretion induced by PMA differed from the release caused by other agents, the findings of the present study indicate that PMA is capable of triggering the platelet release reaction.
Chemical Oceanography (2013)

Over the past ten years, a number of new large-scale oceanographic programs have been initiated. These include the Climate Variability Program (CLIVAR) and the recent initiation of the Geochemical Trace Metal Program (GEOTRACES). These studies and future projects will produce a wealth of information on the biogeochemistry of the world's oceans. Aut
Tapping International Equity Markets Through Depository Receipts : Lessons from the Telecoms Sector (1998)

Ongoing privatization and financial liberalization in emerging economies have let to continuous growth in the number of depository receipt offerings from these countries. Asian and Latin American companies have been the biggest source of offerings. The main advantages of depository receipts stem from the greater market depth and liquidity offered by international capital markets: telecommunications companies are sometimes too big for local markets to absorb, and more active trading attracts a wider shareholder base, implies continuous evaluation of a company's value, and increases management's accountability for a company's financial performance. International offerings also enhance the legitimacy of shares because companies must comply with transparent accounting rules and strict disclosure standards in the host market. Experience has shown that to guard against failure of a depository receipt issue, much effort needs to be put into choosing the right type of depository receipts, marketing the issue, forecasting investor demand, and determining the share price.
Ehring on Parfit's Relation R (1988)

Journal Article Ehring on Parfit's relation R Get access Mark Siderits Mark Siderits Illinois State UniversityNormal, Illinois, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar Analysis, Volume 48, Issue 1, January 1988, Pages 29–32, https://doi.org/10.1093/analys/48.1.29 Published: 01 January 1988