gebhart/patrepeval huggingface dataset:
Infiltration of T Lymphocytes and Expression of ICAM-1 in the Hippocampus of Patients with Hippocampal Sclerosis (2010)

We and others have previously shown that reactive microglia express the major histocompatibility complex (MHC) class I and class II antigens in the hippocampus of patients suffering from epilepsy. Although the MHC glycoproteins serve as restriction elements for T lymphocytes, there is little information available regarding T lymphocytes in hippocampal sclerosis. In the present study, we investigated T lymphocyte infiltration in human hippocampi in four cases of epilepsy with hippocampal sclerosis, as well as in four control cases without neurological disease. No CD8- or CD4-positive T lymphocytes were seen in hippocampi from the control cases. In contrast, CD8- and CD4-positive T lymphocytes had infiltrated into the hippocampi of patients with hippocampal sclerosis. In addition, expression of intercellular adhesion molecule-1 was diffusely upregulated in the hippocampi with hippocampal sclerosis. These results indicate that T lymphocyte infiltration is involved in the pathology of hippocampal sclerosis.
Effects of substituents on the rates of disproportionation of substituted phenylglyoxals in alkaline solution (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of substituents on the rates of disproportionation of substituted phenylglyoxals in alkaline solutionDavid L. Vander Jagt, Liang-Po B. Han, and Charles H. LehmanCite this: J. Org. Chem. 1972, 37, 25, 4100–4104Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/jo00798a028https://doi.org/10.1021/jo00798a028research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Device for the Functional Improvement of Lagophthalmos (2013)

A new device was tested on rabbits for the improvement of lagophthalmos, which causes dryness and irritation of the eye and may cause blindness if untreated. In the presented study, 14 rabbits were injected with local anesthetic to induce temporary facial palsy leading to lagophthalmos on one side. To provide functionality to the upper eyelids, ferromagnetic steel plates were either implanted within the eyelid or taped on the eyelid surface. The device detected blinking in the nonparalytic side and moved the anesthetized paralytic eyelid by pulling the steel plate electromagnetically. The control group (n = 5) did not wear the device, and they could not shut their paralytic eyelids. The treatment group with the external placement of the metal plate (n = 4) and the treatment group with the implant (n = 5) wore the device for artificial blinking. All animals were observed during the experiments, and blinking was recorded on digital video. The data collected from video records were analyzed to test the statistical difference of blinking between control and the treated groups. The results showed that the treatment groups could artificially move their paralytic eyelids. Furthermore, the treatment group with the implant showed a noticeable similarity in eyelid position compared with healthy (nonparalytic) eyes.
Plant-based resist materials for ultraviolet curing nanoimprint lithography (2010)

Plant-based resist materials with liquid trehalose derivatives are investigated to achieve low volumetric shrinkage in ultraviolet curing nanoimprint lithography. This procedure is proven to be suitable for resist material design in the process conditions of ultraviolet curing nanoimprint lithography. The developed plant-based resist material using liquid trehalose derivatives with epoxy groups produces high-quality imprint images of 65-nm line and space. The distinctive bulky glucose structure in trehalose derivatives is considered to be effective for minimizing volumetric shrinkage of resist film during ultraviolet polymerization.
ChemInform Abstract: REACTION OF DICARBONYL(PENTAHAPTO‐CYCLOPENTADIENYL)(OLEFIN)IRON CATIONS WITH SODIUM AZIDE (1975)

Abstract Entgegen einer früheren Veröffentlichung reagieren die Olefin‐Komplexe (I) mit Natriumazid nicht zu einem Isocyanat (V), sondern zum Azid‐Komplex (II), der auch aus dem Chlorid (III) dargestellt werden kann.
The Interaction between Oxidised Chylomicron Remnants and the Aorta of Rats Fed a Normocholesterolaemic or Hypercholesterolaemic Diet (2000)

The effects of oxidised chylomicron remnants on endothelium-dependent relaxation and lipoprotein uptake were studied in both the normocholesterolaemic and hypercholesterolaemic rat aorta in vitro. Incubation of aortic rings taken from normocholesterolaemic animals with oxidised (by treatment with copper sulphate) chylomicron remnant particles resulted in a reduction in both vessel sensitivity and maximum percent relaxation in response to carbachol (CCh) and ATP, without affecting responses to A23187 and S-nitroso-N-acetylpenicillamine (SNAP). Studies comparing control vessels and those taken from fat-fed rats confirmed that hypercholesterolaemia significantly decreased relaxations in response to CCh and potentiated contractions in response to phenylephrine (PE) via a nitric oxide (NO)-dependent mechanism. Perfusion of the aorta of these hypercholesterolaemic rats for 2 h with (125)I-labelled oxidised chylomicron remnants showed that significantly greater amounts of lipoprotein became associated with the artery wall, as compared to control normocholesterolaemic animals. However, there was no significant difference in the uptake of native chylomicron remnant particles between control and hypercholesterolaemic vessels. Taken together, the findings of this study suggest that incorporation of lipoproteins of dietary origin into the arterial wall may contribute to endothelial dysfunction and that their contribution may be enhanced by hypercholesterolaemia. These data also support the putative involvement of oxidative modification in the atherosclerotic process, although the presence of oxidised chylomicron remnants in vivo and their role in atherogenesis remains to be established.
Copolymerization of ethylene and 1‐butene with highly active TI/MG bimetallic catalysts. Effect of partial activation by Alet<sub>2</sub>Cl (1995)

Abstract Copolymerization of ethylene and 1‐butene were performed using the catalyst system TiCl 3 · 1/3 AlCl 3 /MgCl 2 /THF with or without partial activation by AlEt 2 Cl. The catalyst and the copolymers were characterized by IR spectroscopy. The experimental results reveal that partial activation strongly affects the catalytic sensitivity toward 1‐butene and obviously leads to a two‐step polymerization rate profile.
The Application of Graphics Engineering to Gear Design (1986)

<div class="htmlview paragraph">A highly competitive market and increased emphasis on quality have gear designers searching for additional tools to produce accurate gearsets in a condensed timeframe. To meet this challenge, a Graphics Engineering method has been developed to enhance traditional gear design techniques.</div> <div class="htmlview paragraph">Graphics Engineering links interactive graphics, finite element analysis and solid modeling into a graphics/analysis development package. Starting with gear and cutter data derived by conventional techniques, it provides cutter paths and involute profiles for geometry, strength, and physical property analysis.</div> <div class="htmlview paragraph">The comprehensive data obtained through Graphics Engineering provides a powerful tool for the gear designer to increase gearset accuracy and reduce design iterations.</div>
Characterization of LDL Particle Size Among Carriers of a Defective or a Null Mutation in the Lipoprotein Lipase Gene (2002)

These results suggest that the null P207L mutation in the LPL gene has a greater impact on LDL particle size than the defective D9N mutation and that this mutation-specific effect is amplified at greater plasma TG concentrations.
HLA–DQA1*0501 is associated with diffuse systemic sclerosis in Caucasian men (2000)

Previous studies have shown associations of DRB1 alleles with SSc, but have rarely determined DQA1 allele frequencies. Our findings indicate that a specific DQA1 allele is associated with SSc, and that DRB1 associations may be due to linkage disequilibrium with DQA1. Moreover, by analyzing genetic susceptibility according to sex, we found that the contribution of HLA genes to the risk of SSc was substantially greater in men than in parous women.
ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL CHARACTERIZATION IN VITRO OF CYCLIC ENKEPHALIN ANALOGS: EFFECT OF CONFORMATIONAL CONSTRAINTS ON OPIATE RECEPTOR SELECTIVITY (1983)

Abstract Gemäß Formelschema werden die Verbindungen (IV) dargestellt.
Living Radical Polymerization from Colloidally-Templated Nanopatterned Surface (2015)

A facile approach of creating well-defined patterned polymer brushes was developed. Herein, different techniques, such as 2D colloidal sphere templating, electrodeposition of a macroinitiator, surface initiated polymerization (SIP), and “click” reaction were utilized and discussed. Controlled radical polymerization (CRP), such as atomic transfer radial polymerization (ATRP) and reversible-addition chain transfer radical (RAFT), are mainly used for SIP for well-controlled polymer brush architecture, adjustable polymer film thickness, and possible block copolymer formations. The modifiable terminal groups of the polymers after CRP provided an opportunity to “graft onto” the nanopatterned surface via a “click” reaction. In this section, our recent work about “polymer brush on a colloidal nano-patterned conducting substrate” are demonstrated in detail, which includes the design, methologies, and related results.
Development and validation of high-density SNP array in ducks (2019)

Development and validation of high-density SNP array in ducks. XIth European symposium on poultry genetics (ESPG)
Sestrin 2 Protein Regulates Platelet-derived Growth Factor Receptor β (Pdgfrβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions (2015)

We recently identified the antioxidant protein Sestrin 2 (Sesn2) as a suppressor of platelet-derived growth factor receptor β (Pdgfrβ) signaling and Pdgfrβ signaling as an inducer of lung regeneration and injury repair. Here, we identified Sesn2 and the antioxidant gene inducer nuclear factor erythroid 2-related factor 2 (Nrf2) as positive regulators of proteasomal function. Inactivation of Sesn2 or Nrf2 induced reactive oxygen species-mediated proteasomal inhibition and Pdgfrβ accumulation. Using bacterial artificial chromosome (BAC) transgenic HeLa and mouse embryonic stem cells stably expressing enhanced green fluorescent protein-tagged Sesn2 at nearly endogenous levels, we also showed that Sesn2 physically interacts with 2-Cys peroxiredoxins and Nrf2 albeit under different reductive conditions. Overall, we characterized a novel, redox-sensitive Sesn2/Pdgfrβ suppressor pathway that negatively interferes with lung regeneration and is up-regulated in the emphysematous lungs of patients with chronic obstructive pulmonary disease (COPD).
Evolution of altruists and cheaters in near-isogenic populations of Escherichia coli (2009)

Emergence of antibiotic-resistant bacteria threatens the continued efficacy of many critical drugs used to treat serious infections. What if such resistant organisms could also act as altruists and "share" their resistance with sensitive cohorts without any actual genetic exchange? We competed resistant strains that differ solely in their ability to secrete a plasmid-encoded beta-lactamase. Sensitive strains were otherwise isogenic with their resistant counterparts and were either plasmid-free or contained a "Dummy" plasmid of roughly the same size as that of the resistance plasmids. Absent antibiotic selection, plasmid-free sensitive strains outperformed the plasmid-bearing strains. In the presence of ampicillin, the outcome depended on whether the resistant strain secreted its beta-lactamase (Altruist) or retained it (Selfish). In the latter case, only resistant cells survived. When beta-lactamase was secreted, some sensitive cohorts were also provided protection, with the largest fitness increase provided to plasmid-free cells. However, some Altruist strains appeared to be at a disadvantage, as a great deal of their enzyme broke off cells. Thus, additional variables must be considered when designing microbial competition experiments.
Photosensitivity, chemical composition gratings and optical fiber based components (2002)

The different topics of this thesis include high-temperaturestable fiber Bragg gratings, photosensitivity and fiber basedcomponents. Fiber Bragg gratings (FBG) are wavelength dispersiverefractive index structures manufactured through UV exposure ofoptical fibers. Their applications range from WDM filters,dispersion compensators and fiber laser resonators fortelecommunication applications to different types of point ordistributed sensors for a variety of applications. One aim of this thesis has been to study a new type of FBGreferred to as chemical composition grating. These gratingsdiffer from other types of FBG in that their refractive indexstructure is attributed to a change in the chemicalcomposition. Chemical composition gratings have shown to beextremely temperature stable surviving temperatures in excessof 1000 oC. Photosensitivity of pure silica and germanium-dopedcore fibers in the presence of hydroxyl groups has also beenstudied and different types of fiber based components have beendeveloped. The main result of the thesis is a better understanding ofthe underlying mechanism of the formation of chemicalcomposition gratings and their decay behavior at elevatedtemperatures. The refractive index modulation is caused by aperiodic change in the fluorine concentration, which has beenverified through time-of-flight secondary-ion-mass spectrometryand through studies of the decay behavior of chemicalcomposition gratings. A model based on diffusion of dopants hasbeen developed, which successfully predicts the thermal decayat elevated temperatures. Studies of the dynamics of chemicalcomposition grating formation have resulted in a manufacturingtechnique that allows for reproducible gratingfabrication. The main results regarding photosensitivity is a method tosignificantly increase the effect of UV radiation on standardtelecommunications fiber. The method, referred to asOH-flooding, has also been applied to pure-silica core fibersresulting in the first report of strong grating formation insuch fibers. Finally, research into different schemes for developingfiber-based components has resulted in two types of singlefiber integrated Mach-Zehnder interferometers; one passiveinterferometer that can be used as an optical filter and oneactive interferometer controlled with internal metalelectrodes. Keywords:optical fibers, fiber Bragg gratings,photosensitivity, thermal stability, fiber sensors, chemicalcomposition gratings, fiber components, Mach-Zehnderinterferometer, optical switch, optical modulator.
Fermentation monitoring by polymeric‐resin‐based microbiol assay (1983)

A polymeric-resin-based microbiological assay is shown to yield results consistent with classical inhibition zone theory. This novel assay is applicable to cycloheximide, an antifungal antibiotic, at concentrations below 1.0 mug/mL and up to 800 mug/mL. Addition of ethanol to the cut-out wells of the assay plate helps to release the antibiotic and drastically increases the inhibition zone size. The antibiotic concentrations of both two component and multicomponent systems can be determined using this method. The use of polymeric-resin beads to monitor antibiotic concentrations is shown to be an effective technique for fermentation monitoring.
Characterization of a novel facultative <i>Methylocystis</i> species capable of growth on methane, acetate and ethanol (2010)

A non-motile strain of Methylocystis, strain SB2, isolated from a spring bog in southeast Michigan, had a curved rod morphology with a typical type II intracytoplasmic membrane system. This organism expressed the membrane-bound or particulate methane monooxygenase (pMMO) as well as a chalkophore with high affinity for copper and did not express the cytoplasmic or soluble methane monooxygenase (sMMO). Strain SB2 was found to grow within the pH range of 6-9, with optimal growth at 6.8. Growth was observed at temperatures ranging between 10°C and 30°C, with no growth at 37°C. The DNA G+C content was 62.9 mol%. Predominant fatty acids were 18:1ω7c (72.7%) and 18:1ω9c (24%) when grown on methane. Phylogenetic comparisons based on both pmoA and 16S rRNA sequences indicated that this organism belonged to the Methylocystis genus, and was closely related to Methylocystis rosea SV97(T) and Methylocystis echinoides IMET10491(T) (98% 16S rRNA gene sequence similarity to both strains). DNA : DNA hybridizations indicated that strain SB2 had 70% similarity with M. rosea SV97(T) . Unlike M. rosea SV97(T) , strain SB2 was able to utilize not only methane for growth, but also ethanol and acetate. Furthermore, the predominant fatty acids in strain SB2 were different from those found in M. rosea SV97(T) , i.e. 54.2% and 39.7% of fatty acids are 18:1ω8 and 18:1ω7 in M. rosea SV97(T) , while 18:1ω8 is completely absent in strain SB2.
Feedback-enhanced squeezing in second-harmonic generation (1995)

Second-harmonic generation, in a cavity resonant only at the fundamental, produces amplitude squeezing in both the fundamental and the second harmonic, with optimal squeezing of -1/3 and -8/9, respectively, at low frequency. It also produces nonclassical correlations between the two output beams. We show that these correlations can be used to enhance the squeezing in either beam by constructing a feedback loop. By using the second-harmonic photocurrent to control the amplitude of the pump, the optimal fundamental squeezing is enhanced by 50% to -1/2. The limit of -8/9 for the seocnd harmonic (for infinite nonlinearity strength) cannot be improved by feeding back the fundamental. However, for any fixed finite nonlinearity, such feedback can produce significant enhancement, with a maximum of 50%. Even with the losses characteristic of a practical experiment included, the enchancement offered by the feedback is still significant, being greater than 20% in either mode.
ChemInform Abstract: 6SUBSTITUIERTE PENICILLIN‐DERIVATE 6. MITT. (1973)

Abstract Aus der Schiffschen Base (I) erhält man mit überschüssigem Acrylnitril (II) in tert.‐Butanol in Gegenwart von N,N‐Diisopropyläthylamin die Addukte (III) und (IV), von denen (IV) zu (V) hydriert und gespalten wird.
A New Species of Cyperus (Cyperaceae) from Costa Rica and Mexico (1982)

Cyperus herndoniae is described, illustrated, and compared to its nearest relative, C. distans. It is known from collections from Guanacaste Province, Costa Rica, and Chiapas, Mexico. During the course of my work on Cyperus in Costa Rica and Panama, an undescribed species was noted from two collections made by R. L. Wilbur in Guanacaste Province. Later, a third collection made by D. E. Breedlove in Chiapas, Mexico, was detected. Cyperus herndoniae Tucker, sp. nov., fig. 1.-TYPE: Costa Rica, Guanacaste, local in ditch at the entrance of the Santa Rosa National Park, 21 Jul 198 1, Wilbur 31825 (holotype: DUKE; isotypes: CR, F, GH, MO). Rhizoma ascendens, ad 2 cm longa. Radii simplices. Spiculae linearilanceolatae, 8-16 mm longae, 1.5-2.1 mm latae. Squamae divaricatae, ellipticae, 3-3.2 mm longae, 1.5-1.9 mm latae. Achaenium trigonum, oblongum, 2-2.2 mm longum, 0.6-0.7 mm latum. Affinis Cypero distanti L.f. Culms single or 2-3 together, 30-75 cm tall, trigonous, smooth; basally indurate. Rhizomes up to 2 cm long, turning upward. Roots fibrous. Leaves 1-4, 20-40 cm long, 2-3 mm wide, margins scabrellate. Inflorescence bracts 3-6, 2-25 cm long, 1-6 mm wide, borne horizontally, margins scabrellate. Rays (4-)6-8, up to 5 cm long, unbranched. Spikes ovoid to hemispherical, (5-)15-35 mm long, 17-45 mm wide; rachis 3-12 mm long. Spikelets (10-)25-50 per spike, linear-lanceolate, compressed, 816 mm long, 1.5-2.1 mm wide; rachilla slightly flexuous, its wings hyaline, 0.3-0.4 mm wide. Scales 4-12 per spikelet, elliptic, 3-3.2 mm long, 1.3-1.9 mm wide, obtuse, mucronulate, borne divaricately on the rachilla, laterally 2-3-nerved, brown to stramineous, the margins hyaline, the keel 3-nerved, greenish. Stamens 3; filaments ribbonlike, 3.5-4 mm long; anthers oblong, 0.9-1.1 mm long. Styles 0.4-0.7 mm long; stigmatic branches 3, 2.5-3 mm long. Achenes trigonous, oblong, 2-2.2 mm long, 0.6-0.7 mm wide, apiculate, slightly stipitate, angles rounded, faces flat to slightly convex, finely papillose, brown. Distribution. Roadsides, wet marshy depressions, and low flats from sea level to 700 m. Flowering and fruiting specimens have been collected in Jul, Aug, and Sep. Specimens examined. Costa Rica. Guanacaste: just outside Santa Rosa National Park, Wilbur 30970 (DUKE); 14 km S of La Cruz, Wilbur 30928B (DUKE); about 18 km N of
Effect of PTX3 and Voriconazole Combination in a Rat Model of Invasive Pulmonary Aspergillosis (2012)

This study evaluated the pharmacological activity of PTX3, administered in combination with voriconazole, in a rat model of pulmonary aspergillosis. The data indicated additive therapeutic activities of these compounds, as demonstrated by the amelioration of respiratory function changes, reduction of lung fungal burden, and increased survival. Overall, we provide clear evidence that the combination of PTX3 with a suboptimal dose of voriconazole might represent a therapeutic option under those clinical conditions where the use of voriconazole alone is not warranted for efficacy and tolerability reasons.
Ionized impurity scattering in periodically δ-doped InP (1997)

The quantum mobility in the individual minibands of InP with periodic Si \ensuremath{\delta} doping was estimated from the Shubnikov--de Haas spectra of the samples, measured at 4.2 K in fields of 0--14 T. The set of samples studied had a sheet density of Si atoms of about 4.9\ifmmode\times\else\texttimes\fi{}${10}^{12}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}2}$ in each doped layer, and a doping period in the range 90--300 \AA{}. A theoretical model for the quantum mobility in individual minibands was developed, and theoretical estimates of the quantum mobility are in reasonable agreement with the experimental values. It is observed that at a fixed doping period the quantum mobilities increase with the index of the miniband, and the quantum mobility in an individual miniband decreases when the doping period is made shorter. The dependence of the quantum mobility on the miniband index and doping periodicity correlates with the dependence of the mean distance between electrons and the doped layer on the same quantities. These results demonstrate that in \ensuremath{\delta}-doped semiconductors the binding length of the quantum-confined electronic charge is a very important parameter, determining the carrier mobility which can be attained in these systems.