gebhart/patrepeval huggingface dataset:
Understanding the Mechanism of the Antimitogenic Activity of Suramin (2005)

Fibroblast growth factors (FGFs) play crucial roles in the regulation of key cellular processes such as angiogenesis, differentiation, and tumor growth. Suramin, a polysulfonated naphthylurea, is known to be a potent inhibitor of FGF-induced angiogenesis. Using isothermal titration calorimetry, we demonstrate that human acidic fibroblast growth factor (hFGF-1) binds to suramin with high affinity in the nanomolar range. The suramin:hFGF-1 binding stoichiometry is estimated to be 2:1. Size-exclusion chromatography data reveal that suramin oligomerizes hFGF-1 to form a stable tetramer. Thermal unfolding experiments monitored by steady state fluorescence, and limited trypsin digestion analysis data suggest that suramin-induced oligomerization of hFGF-1 occurs in two steps. The first step involves the binding of suramin at specific sites on the protein. Two molecules of suramin appear to bind simultaneously to one molecule of hFGF-1. Binding of suramin possibly involves formation of solvent-exposed nonpolar surfaces in hFGF-1. In the second step, FGF appears to oligomerize through coalescence of the solvent-accessible nonpolar surfaces. Results of the NMR experiments reveal that suramin binds to residues in the heparin binding pocket as well as to residues involved in FGF receptor binding. On the basis of the results of this study, we propose a model to explain the molecular mechanism(s) underlying the antimitogenic activity of suramin. To our knowledge, this is the first study in which suramin interaction sites on FGF have been characterized.
Dynamics of Macrophage Trogocytosis of Rituximab-Coated B Cells (2011)

Macrophages can remove antigen from the surface of antibody-coated cells by a process termed trogocytosis. Using live cell microscopy and flow cytometry, we investigated the dynamics of trogocytosis by RAW264.7 macrophages of Ramos B cells opsonized with the anti-CD20 monoclonal antibody rituximab. Spontaneous and reversible formation of uropods was observed on Ramos cells, and these showed a strong enrichment in rituximab binding. RAW-Ramos conjugate interfaces were highly enriched in rituximab, and transfer of rituximab to the RAW cells in submicron-sized puncta occurred shortly after cell contact. Membrane from the target cells was concomitantly transferred along with rituximab to a variable extent. We established a flow cytometry-based approach to follow the kinetics of transfer and internalization of rituximab. Disruption of actin polymerization nearly eliminated transfer, while blocking phosphatidylinositol 3-kinase activity only resulted in a delay in its acquisition. Inhibition of Src family kinase activity both slowed acquisition and reduced the extent of trogocytosis. The effects of inhibiting these kinases are likely due to their role in efficient formation of cell-cell conjugates. Selective pre-treatment of Ramos cells with phenylarsine oxide blocked uropod formation, reduced enrichment of rituximab at cell-cell interfaces, and reduced the efficiency of trogocytic transfer of rituximab. Our findings highlight that dynamic changes in target cell shape and surface distribution of antigen may significantly influence the progression and extent of trogocytosis. Understanding the mechanistic determinants of macrophage trogocytosis will be important for optimal design of antibody therapies.
Customizable physical interfaces for interacting with conventional applications (2002)

When using today's productivity applications, people rely heavily on graphical controls (GUI widgets) as the way to invoke application functions and to obtain feedback. Yet we all know that certain controls can be difficult or tedious to find and use. As an alternative, a customizable physical interface lets an end-user easily bind a modest number of physical controls to similar graphical counterparts. The user can then use the physical control to invoke the corresponding graphical control's function, or to display its graphical state in a physical form. To show how customizable physical interfaces work, we present examples that illustrate how our combined phidgets® and widget tap packages are used to link existing application widgets to physical controls. While promising, our implementation prompts a number of issues relevant to others pursuing interface customization.
Dynamics of tilt-based browsing on mobile devices (2007)

A tilt-controlled photo browsing method for small mobile devices is presented. The implementation uses continuous inputs from an accelerometer, and a multimodal (visual, audio and vibrotactile) display coupled with the states of this model. The model is based on a simple physical model, with its characteristics shaped to enhance usability. We show how the dynamics of the physical model can be shaped to make the handling qualities of the mobile device fit the browsing task. We implemented the proposed algorithm on Samsung MITs PDA with tri-axis accelerometer and a vibrotactile motor. The experiment used seven novice users browsing from 100 photos. We compare a tilt-based interaction method with a button-based browser and an iPod wheel. We discuss the usability performance and contrast this with subjective experience from the users. The iPod wheel has significantly poorer performance than button pushing or tilt interaction, despite its commercial popularity.
FrameNet: A Knowledge Base for Natural Language Processing (2014)

in Berkeley, California (http:
Evaluation of Decision Feedback Equalization and Viterbi Algorithm Detection for Voiceband Data Transmission--Part I (1976)

The application of QAM receivers employing passband decision feedback equalization or Viterbi algorithm detection is considered for high-speed data transmission in voiceband telephone channels. Analytical results for the Viterbi receiver indicate that it can permit digital data transmission with symbol rates exceeding the nominal bandwidth capabilities of the channel. However, it is also shown that the minimum distance of partial response-type impulse responses can substantially decrease due to small demodulation phase errors. Thus, decision feedback receivers may offer more robust performance on channels with phase jitter.
New books - Active carbon: Manufacture, properties, and applications (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew books - Active carbon: Manufacture, properties, and applicationsMilan Smisek and Slavoj CernyCite this: Anal. Chem. 1970, 42, 14, 81APublication Date (Print):December 1, 1970Publication History Published online21 September 2008Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/ac50160a026https://doi.org/10.1021/ac50160a026research-articleACS PublicationsRequest reuse permissionsArticle Views234Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Seamless and transparent migration for TCP sessions (2014)

Personal communication devices are extensively used for mobile computing thanks to ever increasing wireless coverage and processing capability. However, they are constrained in terms of both human interaction (screen size and resolution, keyboard) and lifetime; hence mobile computing often relies on the possibility to migrate applications and communication sessions among several (fixed or mobile) devices. Session migration is a challenging feature, especially when communication with other hosts is involved, and the current Internet architecture does not support natively this paradigm. In this paper, we address seamless and transparent session migration for the Transmission Control Protocol (TCP) that maintains compatibility with current Internet; hence, our work keeps the remote TCP peer unaware of the migration process. We describe the latest features of the Linux kernel that allow the migration of a TCP session and a couple of alternatives to divert network packets towards the new destination.
Investigation of the recovery of the binocular visual function after the operation for children cataract (2001)

目的:评价儿童白内障人工晶体植入术后双眼视功能的恢复情况方法:对60例14岁以下儿童白内障人工晶体植入术后视功能恢复情况进行回顾性研究.将病人分为单眼先天性白内障、单眼外伤性白内障和双眼先天性白内障三组,随访时间为术后半年至3年半,对每位患者进行了最好矫正视力、眼位及双眼视功能检查.结果:60例病人最好矫正视力达到0.5以上的有33例(55%),具有融合功能的有28例(47%),达到≤200秒弧度立体视觉的只有15例(25%),在三组病人中,单跟外伤性白内障的术后视力及双眼视功能恢复情况明显好于单眼先天性白内障.结论:儿童白内障人工晶体植入术后可以获得较满意的视力效果,但双眼视功能的恢复情况往往不理想.对儿童先天性白内障在视觉尚未发育成熟之前尽早进行手术、儿童外伤性白内障在伤后早期进行人工晶体植入,将有利于儿童白内障术后双眼视功能的恢复.
Separation of cell types from embryonic chicken and rat spinal cord: characterization of motoneuron-enriched fractions (1981)

Single cell suspensions prepared from embryonic chick or rat spinal cords were separated into morphologically and functionally distinct subpopulation based on their buoyant densities The lightest fraction (F-1) was highly enriched for cells containing the enzyme choline acetyltransferase (CAT), a marker for developing motoneurons. The morphology biochemistry, and in vitro development of this and other spinal cord cell fractions isolated by the outlined procedure were investigated. Spinal cords, dissected from 6-day chick or 12-day rat embryos, were dissociated with trypsin and applied to iso-osmotic metrizamide density gradients. After brief centrifugation, biochemical analysis revealed that cholinergic cells migrated to lower densities than other spinal cord cells. The use of discontinuous density gradients allowed rapid and simple isolation of three fractions of viable cells (designated F-1 to F-3, lowest to highest density). Characterization of chicken and rat embryo cell fractions gave similar results. The cells in Fraction 1 were large with prominent nuclei and nucleoli, while those in F-2 and F-3 were distinctly smaller. Fraction 1 was highly enriched for cholinergic cells. The CAT specific activity (CAT/cell) was increased 400% in Fraction 1 compared to unfractionated cells, while CAT specific activity in F-2 and F-3 was reduced to 25% and less than 4% that of unfractionated cells, respectively. The recovery of cholinergic cells using this procedure was much better than with other published procedures; greater than half the spinal cord CAT activity was routinely recovered in the enriched fraction. The cholinergic-enriched cells (F-1) were unique in their in vitro growth characteristics. All fractions had neuronal cells, while non-neuronal cells were distributed primarily in F-3, fewer in F-2, and were essentially absent from F-1. Neurons in F-2 and F-3 remained viable under a variety of conditions, most of which were not supportive of F-1 cell survival. The cholinergic-enriched F-1 cells survived and developed only in the presence of muscle cells or in muscle-conditioned medium on highly adhesive substrata. Large, multipolar neurons predominated under these conditions. The method described provides a means of characterizing the factors involved in the development of distinct populations of cells from the embryonic spinal cord.
High Emissivity Coatings in Glass Furnaces (2014)

This chapter contains sections titled: Background High Emissivity Coatings Commercial High Emissivity Coating Update Benefits of Using High Emissivity Coatings Factors Adversely Affecting the Evaluation or Performance of High Emissivity Coatings High Emissivity Coating on Owens Corning Insulation Furnaces Future Directions Acknowledgement
Control of heme content in Vitreoscilla by oxygen. (1982)

Protoheme IX is the only heme type present in Vitreoscilla, an obligate aerobe of the Beggiatoaceae family. Previous work showed that the heme content of Vitreoscilla cells was very dependent on growth conditions and that cells with high heme content also had a higher respiratory rate and a higher concentration of cytochrome o, the terminal oxidase. Experiments reported here showed that oxygen exerts a primary control on the heme content of Vitreoscilla and that the concentration of the peptone-yeast extract-acetate medium (PYA) was also important. There was an optimum shaking rate at each PYA concentration for maximum heme content and an optimum PYA concentration for each shaking rate. The atmospheric oxygen concentration of the shaking growth medium remained at 100% saturation and then began a rapid decline (t1/2 ca. 1hr) to less than 10% saturation. The time at which this decline began depended on both the PYA concentration and shaking rate at a fixed inoculum. The heme content of the cells increased over 50 fold as the oxygen concentration in the medium decreased during culture. Cells with a sub-maximal heme content exposed for two hr to 1) anaerobic conditions showed a 15% decrease in heme content; 2) 50% atmospheric oxygen, a 26% increase in heme content; 3) 100% atmospheric oxygen, an 80% decrease in heme content. The results show that the optimal oxygen concentration for maximum heme content in Vitreoscilla is relatively low, probably less than 10% atmospheric.
Semiconducting Behavior of Substituted Tungsten Diselenide and Its Analogues (1964)

Tantalum substitutions up to 5 atomic per cent (a/o) of the cations have been made in the three Group VIB dichalcogenides, , , and . Tantalum‐substituted p‐type had the best thermoelectric properties with a figure of merit about . Substitution of a number of other elements was attempted in the compounds and , but only the Group VB metals were sufficiently soluble to give p‐type materials with electrical conductivities at useful levels. Hall coefficient measurements were made on all three of the above‐mentioned compounds, and was shown to have the highest carrier mobility (100 cm2/v‐sec); this explains its superior thermoelectric properties. An excellent correlation is shown between Seebeck coefficient measurements and Hall coefficient measurements for the family of compositions for an effective mass ratio of 1.0 with the assumption of an ionic lattice scattering mechanism.
Storm over Statins — The Controversy Surrounding Pharmacologic Treatment of Children (2008)

In July, the American Academy of Pediatrics released revised recommendations for the management of hypercholesterolemia in children, and within days, it had elicited a firestorm of controversy. Drs. Sarah de Ferranti and David Ludwig discuss the inclusion of statins as potential first-line pharmacologic agents.
Distribution of Small Grain Residue Produced by Combines<sup>1</sup> (1985)

Abstract A uniform distribution of small grain residues is needed in conservation tillage systems, but measurements are needed to describe the degree of uniformity or nonuniformity actually produced by combines. A combination of hand‐cut bundles of wheat ( Triticum aestivum L.) plus straw before a combine pass; straw plus chaff deposit on a canvas apron and hand‐cut bundles of the uncut stubble were used to measure the distribution of small grain residue produced by 12 test combines. Header width varied from 5.5 to 7.3 m, grain production from 4.8 to 7.1 Mg/ha, and straw (plus chaff) production from 9.0 to 11.4 Mg/ha. From 52 to 64% of the straw plus chaff was threshed. An uneven residue distribution ratio (URDR) of maximum total to minimum total residue varied from 1.4 to 5.1 depending on combine and residue distribution system. A dispersion index (DI), which ranges from 0 for an even distribution to approximately 0.5 for a severely uneven distribution, varied from 0.09 to 0.42. All test combines with a standard flail spreader gave DI > 0.23. Dispersion indexes ≤ 0.14 were produced by a retrofit chaff spreader on a cylinder‐type combine, a farm‐shop modified flail spreader system on a rotary‐type combine, and an experimental straw chopper on a rotary combine. Agronomic and machinery operation problems associated with chaff rows suggest an URDR < 1.5 is needed to successfully manage no‐till after small grain harvest. A DI < 0.1 can be attained without excessive costs to improve spreading devices.
Copyright & Privacy - Through the Political Lens, 4 J. Marshall Rev. Intell. Prop. L. 306 (2005) (2005)

Veteran beltway players discuss the politics of P2P technology and Privacy. How far can or should Congress go? Can the United States export its values or its laws in this area? Are content owners in a losing Luddite struggle? What is the role of litigators, lobbyists and legislators in this war?
LONG PULSE LASER EMISSION FROM RHODAMINE 6 G USING CYCLOOCTATETRAENE (1970)

Long pulse laser emission is obtained from Rhodamine 6 G using cyclooctatetraene to quench the triplet state of the dye. It is found that cyclooctatetraene is at least as effective as molecular oxygen.
Comparative Study of Methylene Blue and Erythrosine Dyes Employed in Photodynamic Therapy for Inactivation of Planktonic and Biofilm-Cultivated <i>Aggregatibacter actinomycetemcomitans</i> (2010)

PDT using MB or ERY as a photosensitizing agent and odontologic resin photopolymerizer as a light source could be an efficient option for pocket decontamination in aggressive periodontal disease.
Relationship between the astrometric z-term, the Earth rotation and the southern oscillation index. (1994)

The z-term series derived from astronomical observations is related to plumb-line deflection. Its analysis over the interval 1962-1982 reveals interannual variations with amplitudes of about 0.01&#39;&#39;. These variations appear to be significantly correlated with both the length-of-day variations and the Southern Oscillation Index characterizing El Nine events, and this with a time lag of about 12 months. This z-term series appears to be of great interest in the study of relationships between Earth rotation and geophysical process like in particular oceano-atmospheric phenomena.
A high performance triboelectric generator for harvesting low frequency ambient vibration energy (2014)

We present a novel triboelectric generator for vibration energy harvesting based on the mass production manufacture of flexible printed circuit (FPC). 10 pairs of friction surfaces were integrated on the zigzag-shaped FPC structure, which served as an elastic spring in the mass-spring system. This design makes the triboelectric generator simple and easy to be stimulated. Using industrial FPC manufacture makes the fabrication efficient, low-cost and with high yield. Load circuits can be integrated with the generator without additional assembly. The generator can be operated within a large frequency range from 1 Hz to 200 Hz. Low resonant frequency of 16 Hz and wide bandwidth of 37 Hz were achieved. The maximum effective output power of 77.3 μW was obtained with an optimal load of 10 MΩ at 16 Hz with an oscillation amplitude of 2 mm.
Lightweight wrist photoplethysmography for heavy exercise: motion robust heart rate monitoring algorithm (2015)

The challenge of heart rate monitoring based on wrist photoplethysmography (PPG) during heavy exercise is addressed. PPG is susceptible to motion artefacts, which have to be mitigated for accurate heart rate estimation. Motion artefacts are particularly apparent for wrist devices, for example, a smart watch, because of the high mobility of the arms. Proposed is a low complexity highly accurate heart rate estimation method for continuous heart rate monitoring using wrist PPG. The proposed method achieved 2.57% mean absolute error in a test data set where subjects ran for a maximum speed of 17 km/h.
An Algorithm for Determining the Topological Dimensionality of Point Clusters (1975)

The main thrust of this paper is to present a new algorithm for the analysis of structure in multivariate data point clusters from the standpoint of intrinsic (topological) dimensionality.
Binding of 125I-labeled glucagon and glucagon-stimulated accumulation of adenosine 3‘:5‘-monophosphate in isolated intact rat hepatocytes. Evidence for receptor heterogeneity. (1978)

The binding of "'I-labeled glucagon and its relationship to the glucagon-stimulated production of adenosine 3'5'.monophosphate were investigated in isolated rat hepatocytes at 37°C.The binding data obtained when steady state was approached.or from association and dissociation experiments, could not be adequately described on the basis of one homogeneous population of receptors.Assuming two classes of saturable binding sites, the data could be explained by the existence of approximately 2 x lo4 sites/cell with a dissociation constant (K,,) of about 0.7 nM and approxi-
Linear-assisted DC/DC converters with variable frequency: On their complex control strategies (2014)

Linear-assisted DC/DC converters (or linear-switching hybrid DC/DC converters) consist of a voltage linear regulator (classic NPN or nMOS topologies and LDO) connected in parallel with a switching DC/DC converter. In order to control these hybrid structures, different strategies exist, allowing to fix the switching frequency as a function of some parameters of the linear regulator. This article compares two control strategies that, although can be applied to the same circuital structure of linear-assisted converter, are sensibly different. The first one, reported in previous literature, cancels completely the average current through the linear regulator in steady state to achieve a reduction of the losses. Thus the efficiency of the whole system increases and almost equals the one of the standalone switching converter. The proposed approach, in spite of a slightly increment of linear regulator's losses, reduces the output ripple due to the crossover distortion of linear regulator output stage.