gebhart/patrepeval huggingface dataset:
Utilizing Gaze Data in Learning: From Reading Patterns Detection to Personalization (2015)

Although a lot of attention has been dedicated towards improvement of the modeling of learners’ knowledge within learning systems, recommendation, or personalization, there is less attention on improvement of the learning content itself and providing support to learning content creators. In addition, the complexity of learning systems requires utilization of novel sources of implicit feedback, such as gaze data in order to model learners’ interactions in their entirety. In this poster paper, we present a framework for collection of gaze data and its utilization in the learning systems environment. We focus on the analysis of reading patterns for the detection of problematic parts of text and present results of a preliminary evaluation in a web-based learning system ALEF.
Biochemical and molecular characterization of Bacillus pumilus isolated from coastal environment in Cochin, India (2009)

Bacillus species constitute a diverse group of bacteria widely distributed in soil and the aquatic environment. In this study, Bacillus strains isolated from the coastal environment of Cochin, India were identified by detailed conventional biochemical methods, fatty acid methyl ester (FAME) analysis and partial 16S rDNA sequencing. Analysis of the data revealed that Bacillus pumilus was the most predominant species in the region under study followed by B. cereus and B. sphaericus. The B. pumilus isolates were further characterized by arbitrarily primed PCR (AP-PCR), antibiotic sensitivity profiling and PCR screening for known toxin genes associated with Bacillus spp. All B. pumilus isolates were biochemically identical, exhibited high protease and lipase activity and uniformly sensitive to antibiotics tested in this study. One strain of B. pumilus harboured cereulide synthetase gene cesB of B. cereus which was indistinguishable from rest of the isolates biochemically and by AP-PCR. This study reports, for the first time, the presence of the emetic toxin gene cesB in B. pumilus.
Use of Tunable, Pulsed Dye Laser for Quantitative Fluorescence in Syphilis Serology (FTA-ABS Test) (1974)

A pulsed dye laser was used as an excitation source in a fluorescent treponemal antibody absorption (FTA-ABS) test. A high precision in quantitative fluorescence was obtained with this high-power excitation source coupled to an electronic detection system and a storage oscilloscope by standardization of fluorescence evaluation and through elimination of human error. One 0.4-mus pulse exposure was sufficient to record fluorescence intensity data on the oscilloscope. Absence of fading of fluorescence after repeated excitation permitted multiple readings of the same microscope field. Almost 100% reproducible results were obtained for the FTA-ABS test with 40 samples. Electronic detection of fluorescence and the high sensitivity obtained with laser excitation raise doubts about the relative value of quantitative immunofluorescence in the FTA-ABS test.
Noninvasive assessment of atrioventricular pressure half-time by Doppler ultrasound. (1979)

The mean pressure drop across the mitral valve and atrioventricular pressure half-time were measured noninvasively by Doppler ultrasound in 40 normal subjects, in 17 patients with mitral regurgitation, 32 patients with mitral stenosis and 12 with combined stenosis and regurgitation. In normal subjects pressure half-times were 20--60 msec, in patients with isolated mitral regurgitation 35--80 msec and in patients with mitral stenosis 90--383 msec. There was no significant change in pressure half-time with exercise or on repeat examinations, indicating relative independence of mitral flow. In 25 patients with mitral stenosis and seven with combined stenosis and regurgitation, pressure half-time was related to mitral valve area calculated from catheterization data. Increasing pressure half-times occurred with decreasing mitral valve area, and this relationship was not influenced by additional mitral regurgitation. Noninvasive measurement of pressure half-time together with mean pressure drop was useful for evaluating patients with mitral valve disease.
Designing LC filters for AC-motor drives (2002)

This paper presents practical design guidelines for designing LC filters for AC-motor drive applications. A DC choke and an electrolytic capacitor bank on the DC bus filter the voltage and the current ripples and improve the input power factor. Capacitor and choke values are derived to optimize overall filter performance. Costs associated with the respective component values can then be obtained to analyze cost trade-offs between selected values. Helpful hints are also given.
Recent Advances in Aerosol Therapy for Children with Asthma (2006)

Inhalational drug delivery is the primary mode of asthma therapy in children and is the main focus of this article. Pressurized metered dose inhalers (pMDIs) are now the method of choice in infants and children under 5 years old, when used in combination with an appropriate valved holding chamber or spacer. Spacers are particularly important for steroid inhalation to maximize lung deposition and minimize unwanted oropharyngeal deposition. Optimal inhalation technique with a pMDI-spacer in infants is to inhale the drug by breathing tidally through the spacer. Drug delivery to the lungs using pMDIs can vary greatly, depending on the formulation used and the age of the child. Dry powder inhalers (DPIs) are driven by the peak inspiratory flow of the patient and are usually not appropriate for children under 5 or 6 years of age. Nebulizers continue to play a role in the treatment of acute asthma where high doses of bronchodilator are required, though multiple doses via pMDI spacer may suffice. Important drug delivery issues specific to children include compliance, use of mask versus mouthpiece, lower tidal volumes and inspiratory flows, determination of appropriate dosages, and minimization of adverse local and systemic effects.
Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice (2011)

The development of antidepressants requires simple rodent behavioral tests for initial screening before undertaking more complex preclinical tests and clinical evaluation. Presented in the unit are two widely used screening tests used for antidepressants, the forced swim (also termed behavioral despair) test in the rat and mouse, and the tail suspension test in the mouse. These tests have good predictive validity and allow rapid and economical detection of substances with potential antidepressant-like activity. The behavioral despair and the tail suspension tests are based on the same principle: measurement of the duration of immobility when rodents are exposed to an inescapable situation. The majority of clinically used antidepressants decrease the duration of immobility. Antidepressants also increase the latency to immobility, and this additional measure can increase the sensitivity of the behavioral despair test in the mouse for certain classes of antidepressant. Testing of new substances in the behavioral despair and tail suspension tests allows a simple assessment of their potential antidepressant activity by the measurement of their effect on immobility.
Effects of Growth Hormone on Growth, Insulin Resistance and Related Hormones (Ghrelin, Leptin and Adiponectin) in Turner Syndrome (2007)

IGF-I may be considered as a marker of growth response in TS at short term. Leptin shows a decrease at short term but does not have a correlation with growth response. The decrease in ghrelin in face of unchanged weight seems to be associated with increase in IGF-I and insulin levels. The unchanged adiponectin levels in spite of an increase in insulin levels indicates that adiponectin is mainly affected by weight, not insulin.
The task graph pattern (2010)

This paper presents the Task Graph pattern. Examples of the pattern are presented using the continuation tasks feature of the Task Parallel Library (6), which ships as part of the Microsoft .NET 4 Framework. This pattern is intended to be read in the context of the existing pattern languages for parallel programming; Patterns for Parallel Programming (5) and Our Pattern Language (4).
Software image management for large networks (2003)

One of the difficult problems network administrators encounter in large networks consisting of hundreds and thousands of devices is software management - the problems and issues associated with installing, upgrading, and patching the embedded operating system (OS) running in routers, switches, firewalls, VPN devices, and many other types of devices. The upgrade process for each device may be different depending on the type and capabilities of the device and OS. Wide variations in upgrade procedures may exist, even within the same family of devices. Network administrators require a solution that hides such device-specific details and allows them to focus on the overall task of upgrading software on their network devices in a reliable and robust manner, consistent with prevailing practices and policies in their environment. The paper describes an architecture and framework for solving the problem in a large network. A Web-based application based on this architecture was developed successfully in Java and XML at Cisco Systems.
Cost-Effectiveness in Health and Medicine (1996)

Abstract This is a unique, in-depth discussion of the uses and conduct of cost-effectiveness analyses (CEA) as decision-making aids in the health and medical fields. The product of over two years of deiberation by a multi-disciplinary Public Health Service appointed panel that included economists, ethicists, psychometricians, and clinicians, it explores cost-effectiveness in the context of societal decision-making for resource allocation purposes. It proposes that analysts include a “reference-case” analysis in all CEA’s designed to inform resource allocation and puts forth the most expicit set of guidelines (together with their rationale) ever outlined of the conduct of CEAs. Important theoretical and practical issues encountered in measuring costs and effectiveness, valuing outcomes, discounting, and dealing with uncertainty are examined in separate chapters. These discussions are complemented by additional chapters on framing and reporting of CEAs that aim to clarify the purpose of the analysis and the effective communication of its findings. Primarily intended for analysts in medicine and public health who wish to improve practice and comparability of CEAs, this book will also be of interest to decision-makers in government, managed care, and industry who wish to consider the roles and limitations of CEA and become familiar with criteria for evaluating these studies.
ON CLASSES OF REGULAR GRAPHS WITH CONSTANT METRIC DIMENSION (2013)

在这份报纸，我们由考虑无桥的立方的图的一个班把花 snarks 称为 Jn 正在处理常规图的一些班的公制的尺寸的学习，就开的问题而言的立方的凸的 polytopes 的一个班涨了在[M。Imran 等，有经常的公制的尺寸的飞机图的家庭， Utilitas 数学，在出版社] 并且最后 Harary 图 H5，由部分回答到一个开的问题的 n 求婚了在[我。Javaid 等，有经常的公制的尺寸的常规图的家庭， Utilitas 数学， 2012， 88：4357 ] 。我们证明常规图的这些课有经常的公制的尺寸。与经常的公制的尺寸要求常规图的描述是自然的。
The influence of a complete lower denture destabilization on the pressure of the mucous membrane foundation (2012)

The results of previous studies on the pressures beneath the mucous membrane-supported dentures are contrary to the prevailing pain sensations and discomfort reported in practice. In this work, a FEM analysis of large displacements was used for calculation of the contact stresses beneath a lower denture that accompany destabilization under the realistic oblique mastication forces and stabilization of a non-working flange at the balancing contacts. The pressure on the surface of a mucous membrane beneath a denture that was loaded in a stable manner with a vertical occlusal force of 100 N was lower than the pain threshold. It was even more surprising as the extremely unfavorable lower denture foundation conditions were selected for this analysis. The lateral mastication forces destabilized the denture by means of tilting it and reducing its supporting area. Significant pressures calculated for the destabilization are consistent with the clinically observed decrease or a complete lack of chewing efficiency in the cases of unfavorable foundation conditions. A fundamental importance of the balancing contacts for the chewing efficiency was confirmed quantitatively. A remarkable development which has been achieved in the modeling of the denture functioning conditions is crucial for further biomechanical investigations of the mucous membrane-supported dentures, as well as for the implant-retained dentures.
Homogenization Techniques and Estimation of Material Parameters in Distributed Structures (1991)

We report here on a part of our continuing efforts on the development of high fidelity dynamic models for composite material structures. The focus of our investigations has been on models to be used in estimation and control of large flexible structures mainly intended for use in space (e.g., antennas, platforms, solar panels, experimental arRays, etc.). At present there is a reasonably adequate understanding of the dynamics of beams and plates made from known materials such as aLuminum alloys. Our recent efforts (see [] and the references therein) involved models and methods to determine material parameters in composite material structures with simple geometry (beams with attached solid bodies or solid plates). These result in inverse problems that are computationally tractable as long as the physical geometry is relatively simple. However, substantial difficulties arise in cases involving more complex geometries such as grids (which may be viewed as plates with many holes) and trusses (solid coLumns from which most of the material is removed in some periodic, regular fashion). In these cases the difficulties associated with unknown composite material characteristics such as stiffness and internal damping are combined with severe difficulties related to computational grid selection for a domain that is mostly holes or perforations.
Anterior regeneration in a sexthecal species of lumbricid earthworm (1954)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Clostridium Difficile and Vancomycin-Resistant Enterococcus: The New Nosocomial Alliance (2000)

In conclusion, C. difficile coinfection is common in patients with VRE infection or colonization and is significantly associated with other nosocomial dilemmas like funguria. This may result in the emergence of highly virulent pathogens including vancomycin-resistant C. difficile, posing new challenges in the management of nosocomial diarrheas.
Exploratory wind-tunnel investigation of a wingtip-mounted vortex turbine for vortex energy recovery (1985)

The Langley 8-foot transonic pressure tunnel was used for tests to determine the possibility of recovering, with a turbine-type device, part of the energy loss associated with the lift-induced vortex system. Tests were conducted on a semispan model with an unswept, untapered wing, with and without a wingtip-mounted vortex turbine. Three sets of turbine blades were tested to determine the effect of airfoil section shape and planform. The tests were conducted at a Mach number of 0.70 over an angle-of-attack range from 0 deg. to 4 deg. at a Reynolds number of 3.82 x 10 to the 6th power based on the wing reference chord of 13 in.
Antitumor Effects of Ganoderma Lucidum (1995)

Ganoderma lucidum has been established to be an autitumor natural product. The hot water extracts of the mycelium of G. lucidum (GLP) exhibited antitumor effect against fibrosarcoma in male and female C3H mice and inhibited the metastasis of the tumor to the lung. Moreover, we have fractionated GLP into polysaccharide fraction [GLP(AI)] and non-polysaccharide fraction. We found that GLP (AI) is the major component to show the in vivo antitumor died on fibrosarcoma growth in C3H mice. The effects of GLP (AI) on cytotoxic activity of splenic natural killer cells (NK) were assessed in normal mice and in tumor hearing mice. The rsu1ts show that either intravenous, intraperitoneal or oral administration of GLP (AI) produced a dose-related increase in the splenic NK activity in different mouse strains. In addition, administration of GLP (AI) produced an increase in the titer of serum intertron (IFN). Furthermore, the decreased splenic NK cytotoxicity of tumor-hearing mice was restored by GLP (AI) treatment. The effect of GLP (AI) on the induction of differentiation in leukemic U937 cells was also examined. We found that it could stimulate blood mononuclear cells to secrete cytokines which were both anti-proliferative and differentiation inductive to the leukemnic U937 cells.
Furthermore, antitumor activity of G. lucidum on intraperitoneally implanted Lewis lung carcinoma in synergenic C57BL/6 mice was investigated. The results showed that GLP significantly increasd the life-span of tumor-implanted mice, when administered intraperitoneally alone or in combination with cytotoxic antitumor drugs (adriamycin, fluorouracil, thioguanine, methotrexate, cisplatin) or synthetic immunomodulator (imexon). The GLP was not cytotoxic to cultured cells and the antitumor activity was abolished by pretreatment of mice with cyclosporine. The active principle (s) was found to be present predominantly in the GLP (AI) fraction.
Interleukin-2 and Interferon-α in the Treatment of Patients with Advanced Non-Small-Cell Lung Cancer (1992)

The role of combination chemotherapy in the treatment of advanced non-small-cell lung cancer is controversial. At best, a small survival benefit can be achieved. Therefore, other treatment modalities are needed. On the basis of the promising treatment results with interleukin-2 (IL-2) -containing immunotherapy in renal cell cancer and melanoma, we performed a phase I-II study with IL-2 and interferon alpha (IFN-alpha). Eligible patients were treated with IL-2 18 x 10(6) IU/m2/day by continuous intravenous infusion (c.i.v.) for 3 days. On the same days, 5 x 10(6) U/m2/day IFN-alpha was given intramuscularly. After a rest period of 4 days, patients at the first dose level received IL-2 2.4 x 10(6) IU/m2/day c.i.v. for a period of 28 days, followed by 14 days' rest, 14 days' treatment, 7 days' rest, and a final treatment for 14 days. Patients at the second dose level were treated according to the same schedule, in which the dose of IL-2 was increased to 3.6 x 10(6) IU/m2/day. During low-dose IL-2 treatment, patients received IFN-alpha 5 x 10(6) U/m2/day on days 1 and 4 of each week. Eleven patients were admitted to the study, six at the first and five at the second dose level. Median age was 54 years; all patients had a performance status of 0 or 1. The most important adverse effects included anorexia, fatigue, nausea, and headache, which were not dose limiting. In the 11 patients treated, no responses were seen. Nine patients developed progressive disease during the first 5 weeks of treatment. We concluded that this regimen of IL-2 and IFN-alpha is ineffective.
Youth, Crime, and Cultural Space. (1997)

With rapid progress in DNA synthesis and sequencing, strain engineering starts to be the rate-limiting step in synthetic biology. Here, we report a gRNA-tRNA array for CRISPR-Cas9 (GTR-CRISPR) for multiplexed engineering of Saccharomyces cerevisiae. Using reported gRNAs shown to be effective, this system enables simultaneous disruption of 8 genes with 87% efficiency. We further report an accelerated Lightning GTR-CRISPR that avoids the cloning step in Escherichia coli by directly transforming the Golden Gate reaction mix to yeast. This approach enables disruption of 6 genes in 3 days with 60% efficiency using reported gRNAs and 23% using un-optimized gRNAs. Moreover, we applied the Lightning GTR-CRISPR to simplify yeast lipid networks, resulting in a 30-fold increase in free fatty acid production in 10 days using just two-round deletions of eight previously identified genes. The GTR-CRISPR should be an invaluable addition to the toolbox of synthetic biology and automation.
Monoclonal antibody that defines a unique human T-cell leukemia antigen (1983)

We have generated and characterized a hybridoma monoclonal antibody, termed SN1, that defines a unique human T-cell leukemia antigen. This antibody was generated by using a human leukemia antigen preparation isolated from cell membranes of MOLT-4, a leukemia T-cell line derived from a patient with T-cell-type acute lymphoblastic leukemia (T-ALL). SN1 was characterized by a sensitive microscale radioimmunoassay using a variety of cultured and uncultured human cells. In selected cases, the cell specimens were further tested by immunoperoxidase staining and an immunofluorescence staining test. The results of the radioimmunoassay were in agreement with those of the two other tests. Among the various cultured malignant and nonmalignant cell lines, SN1 reacted only with leukemia T-cell lines derived from patients with T-ALL; it reacted with all six T-ALL cell lines tested-i.e., JM, CCRF-CEM, CCRF-H-SB2, RPMI 8402, PEER, and MOLT-4. In the case of uncultured cell specimens derived from cancer patients, SN1 reacted with four of four cases of T-ALL but did not react with specimens derived from 41 patients with other types of cancer. SN1 did not react with any normal human cell specimens tested, both cultured and uncultured. These specimens include normal lymphoblastoid cell lines, thymocytes, bone marrow cells, spleen cells, lymph node cells, peripheral blood mononuclear cells, lymphocytes containing B and T cells, purified T cells, monocytes, granulocytes, erythrocytes, and platelets. Furthermore, SN1 did not react with phytohemagglutinin-activated T cells nor with concanavalin A-activated T cells. The results show that monoclonal antibody SN1 defines a type of human leukemia antigen that is expressed on the cell surface of T-cell-type ALL cells. The results further show the usefulness of SN1 in the diagnosis of cancer patients and suggest its therapeutic potential. We designate this antigen TALLA, a T-cell ALL antigen.
Forecasting and Inventory Control for Sporadic Demand Under Periodic Review (1987)

A sporadic or lumpy demand pattern is characterized by large transactions separated by periods of zero demand. Such demand patterns occur frequently for items in parts and supplies inventory systems. A forecasting procedure is presented, to be used in conjunction with a base-stock (order-up-to) inventory-control policy under periodic review. The procedure determines the size and timing of replenishment orders. Although a base-stock policy calls for a replenishment order after each transaction, it is shown that a delay in placing the order can result in significant holding-cost reductions with little additional risk or cost of stockouts.
Metabolism of Trehalose in Euglena gracilis (1972)

Abstract Trehalose phosphorylase, an enzyme found in cell-free extracts of Euglena gracilis var. bacillaris, was purified 75-fold by treatment with protamine sulfate, centrifugation at 200,000 x g, and chromatography in a column of hydroxylapatite. This enzyme catalyzes the reversible phosphorolytic splitting of trehalose, yielding β-glucose 1-phosphate and glucose as products. The optimum pH of the reaction was 7.0 for phosphorolysis and 6.3 for the synthesis of trehalose. The equilibrium constant changes with pH. It was 4.2 at pH 7.0 and 17 at pH 6.3. The enzyme is very unstable in the absence of inorganic phosphate, α- or β-glucose 1-phosphate. Measurements in sucrose gradient gave a molecular weight of about 344,000. This enzyme together with a phosphoglucomutase for β-glucose 1-phosphate found in the same Euglena extracts would constitute a new catabolic pathway for trehalose.