gebhart/patrepeval huggingface dataset:
Proteasomes Associated with the Blm10 Activator Protein Antagonize Mitochondrial Fission through Degradation of the Fission Protein Dnm1 (2014)

The conserved Blm10/PA200 activators bind to the proteasome core particle gate and facilitate turnover of peptides and unfolded proteins in vitro. We report here that Blm10 is required for the maintenance of functional mitochondria. BLM10 expression is induced 25-fold upon a switch from fermentation to oxidative metabolism. In the absence of BLM10, Saccharomyces cerevisiae cells exhibit a temperature-sensitive growth defect under oxidative growth conditions and produce colonies with dysfunctional mitochondria at high frequency. Loss of BLM10 leads to reduced respiratory capacity, increased mitochondrial oxidative damage, and reduced viability in the presence of oxidative stress or death stimuli. In the absence of BLM10, increased fragmentation of the mitochondrial network under oxidative stress is observed indicative of elevated activity of the mitochondrial fission machinery. The degradation of Dnm1, the main factor mediating mitochondrial fission, is impaired in the absence of BLM10 in vitro and in vivo. These data suggest that the mitochondrial functional and morphological changes observed are related to elevated Dnm1 levels. This hypothesis is supported by the finding that cells that constitutively overexpress DNM1 display the same mitochondrial defects as blm10Δ cells. The data are consistent with a model in which Blm10 proteasome-mediated turnover of Dnm1 is required for the maintenance of mitochondrial function and provides cytoprotection under conditions that induce increased mitochondrial damage and programmed cell death.
Characterization of InGaAs and InGaAsN saturable absorber mirrors for high power mode locked sub-ps thin-disk lasers (2011)

We report on the characteristic parameters of two types of saturable absorber mirrors: type 1 absorbers contain InGaAs quantum wells whereas absorbers of type 2 have InGaAsN quantum wells. For both types the structure is similar. Both types of absorbers were post-growth annealed in order to characterize the stability under elevated temperatures. We investigated the static and the dynamic reflectivity of the two absorber types in the cases of no post-growth annealing and annealing at 450° C, 650° C, and 700° C, respectively. The absorbers are designed for usage in a sub-ps mode locked Yb:YAG laser at a wavelength of 1030 nm.
The resistivity grid to optimize tomographic 3D imaging (1999)

In this paper a modified version of the old resistivity "AB rectangle" is presented. Here the potential electrodes are located along a regular grid of suitable dimensions, having a triangular or square unitary cell. The current electrodes, instead, are generally located outside of the grid (see figure below), and various directions of the transmitting dipoles may be selected so to optimize the lighting of the subsoil under investigation (as expected the results improve by increasing the number of the directions).
A Double-Blind Comparison of Sertraline and Fluoxetine in Depressed Elderly Outpatients (2000)

Data indicate that both drugs are effective antidepressants for the treatment of depressed elderly outpatients. Differences in cognitive performance effects deserve further investigation.
ChemInform Abstract: A CONVENIENT SYNTHESIS OF 2‐(2‐NITROETHYL)PHENOLS (1985)

Abstract 1‐Hydroxy‐benzaldehyde (I) werden mit Nitromethan (II) in Gegenwart von Dimethylammoniumchlorid und Kaliumfluorid zu 2‐(Z‐Nitroethenyh‐phenolen (III) kondensiert, die mit Boranat zu 2‐(2‐Nitroethyl)‐phenolen (IV) reduziert werden.
The Evaluation of CFCC Liners After Field Testing in a Gas Turbine: V (2005)

Under the Ceramic Stationary Gas Turbine (CSGT) and Advanced Material Program sponsored by the U.S. Department of Energy (DOE), a team led by Solar Turbines Incorporated (Solar) has successfully designed engines utilizing SiC/SiC continuous fiber-reinforced ceramic composite (CFCC) combustor liners. Their potential for low NOx and CO emissions was demonstrated in ten separate field-engine tests for an accumulated duration of more than 68,000-hours. In the first four field tests, the durability of the CFCC liners was limited primarily by the long-term stability of SiC in the high-pressure steam environment of the gas turbine combustor. Consequently, the need for an environmental barrier coating (EBC) to meet the 30,000-hour life goal was recognized. An EBC developed under the National Aeronautics and Space Administration (NASA) High Speed Civil Transport, Enabling Propulsion Materials (EPM) program was improved, optimized and applied on the SiC/SiC liners by United Technologies Research Center (UTRC) from the fifth field test onwards. Presented in this paper is the evaluation of the field test with a modified EBC using Strontium Aluminum Silicate (SAS) on SiC/SiC CFCC liners after 8,368-hours.
Non-Inference: An Information Flow Control Model for Location-based Services (2006)

This paper presents a framework for preserving location privacy without affecting location accuracy. In this framework, services migrate a piece of code to a trusted server, which is assumed to have location information of all the interesting subjects. The code executes on the trusted server, reads location information and sends back results. We introduce Non-inference, a novel information-flow control model that guarantees that the code does not leak exact location information. We discuss the design, implementation and evaluation of a static program analysis technique that enforces non-inference for location based services
The Influence of Martensite on the Corrosion Resistance of Austenitic Stainless Steels (2000)

Abstract This investigation examines the effects of strain-induced martensite on the corrosion resistance of a type 304L stainless steel. Based on electrochemical critical pitting temperature determinations, the presence of varied amounts of α’ martensite had no measurable effects on the pitting resistance of the alloy. The general corrosion rates of the 304L alloy measured in boiling 65wt.% nitric acid and boiling 20wt.% phosphoric acid were not affected by the presence of α’ martensite. The active corrosion rate measured in 10wt.% sulfuric acid at 50°C was found to increase with increasing amounts of α’ martensite. The increased hydrogen embrittlement susceptibility of the 304L alloy with increasing amounts of α’ martensite is discussed.
Synthesis and Antiviral Effect of Alkylated Barbituric Acid (1961)

Assuming that antiviral compounds might be obtained by introduction of a higher alkyl group into the structure of barbituric acid, 28 compounds of this series were prepared and their in vivo effect against Nakayama strain of Japanese B encephalitis virus was examined in mice. It was thereby found that the compound effective on this virus are 3-methyl-5-propyl-, 3-allyl-, 3-benzyl-5-methyl-, and 3-butyl-5-methyl-5-lauryl-barbituric acids, and 3-benzyl-5-ethyl-5-phenyl- and 3-benzyl-5, 5-diethyl-barbituric acids.
A Case of Pure Red Cell Aplasia Associated with Pregnancy (2012)

赤芽球癆は選択的に赤血球系の産生のみが低下ないし欠損する疾患である．後天性赤芽球癆の原因には，胸腺腫，悪性腫瘍，自己免疫疾患，ウイルス感染，腎不全，薬剤などがある．症例は20歳代女性．妊娠26週に貧血を認め，骨髄検査で赤芽球系の著明な低形成を認め赤芽球癆を疑った．妊娠以外の原因を疑う所見はなく，赤血球輸血を行いながら妊娠を継続し，自然経腟分娩で出産した．その後，無治療で貧血は改善した．一連の経過より妊娠関連赤芽球癆と考えられた．
Control of mutual phase locking of monolithically integrated semiconductor lasers (1983)

The mutual coherence of two coupled semiconductor lasers is investigated experimentally. It is demonstrated that by varying the gain in the overlap region, the degree of phase coherence can be continuously controlled. The quantitative characterization of the degree of phase coherence by fringe visibility is demonstrated.
Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts (2018)

Our findings support that T2D was associated with a moderately higher risk of developing CRC in men; a weaker, nonsignificant positive association was observed in women.
A Fine-Wire Microtemperature Probe for Atmospheric Measurements (1975)

Abstract : Refractive-index fluctuations which affect optical propagation depend mostly on microthermal variations. Fine wire probes are sufficient to measure microtemperature so long as we have ready access to the propagation medium. A complete sensor unit currently in use includes the probe, a Wheatstone bridge and amplifier circuit, and a mechanical support assembly. In providing complete details on how to construct such a unit, we concentrated on a design developed in-house which we know to be effective. The unit is found to have a frequency range better than 0.01 to 100 Hz and responds to minimum temperature fluctuations of 0.015C. Of special importance is the low construction cost of only about $200.
Decreased Endosteal Intramembranous Bone Formation Accompanies Aging in a Mouse Model of Distraction Osteogenesis (2002)

This paper describes a study conducted to test the hypothesis that aging will result in decreased bone formation during distraction osteogenesis (DO). DO is a unique clinical method for the stimulation of new bone formation and subsequent bone lengthening. When applied to other species DO reflects the clinical situation in which older DO patients demonstrate significant delays in mineralization. Given the considerable value of mouse genetics for studying the mechanism(s) of bone formation, we have developed a murine DO model and utilized it to investigate the effect of age on bone formation. Four- and 12-month-old CB57BL/6 male mice (n = 10 per group) underwent DO. External fixators were placed on the left tibiae, and mid-diaphyseal tibial osteotomies were performed immediately following fixator placement. Distraction, which began 6 days after surgery at 0.075 mm twice a day (0.15 mm/day) for 14 days, resulted in a total lengthening of 2.1 mm. Following distraction, the distracted tibiae were removed for high-resolution radiography and histological evaluation. Analysis of radiographs and representative histological sections was performed by video microscopy. Radiographic analysis demonstrated a significant decrease in the mineralized area of distraction gaps of 12- (33.5 ± 4.8%) versus 4-month-old (51.4 ± 5.4%) mice (p < 0.039). Histological analysis of representative specimens confirmed the decrease in bone formation observed in the radiographs (p < 0.001). Endosteal new bone was predominantly intramembranous and appeared highly oriented toward the distraction axis. These results suggest that 12-month-old mice have a relative deficit in endosteal bone formation compared with that in younger mice. The application of this murine DO model to genetically manipulated mice may provide critical insights into the mechanisms of bone formation, repair, and regeneration in a geriatric setting.
Functional Nanocomposites Based on Fibrous Clays (2016)

This chapter is focused on functional nanocomposites based on the use of the microfibrous clays sepiolite and palygorskite as efficient fillers for diverse types of polymer matrices, from typical thermoplastics to biopolymers. The main features that govern the interaction between the silicates and the polymer matrix are discussed. The introduction addresses the structural and textural features of the fibrous silicates, as well as the possible synthetic approaches to increase the compatibility of these nanofillers with the polymeric matrix. Additionally, these clays can be easily functionalized through their surface silanol groups based on chemical reactions or by anchoring of nanoparticles. This allows for the preparation of a wide variety of functional polymer–clay nanocomposites. Thereafter, some relevant examples of nanocomposites derived from conventional polymers are reported, as well as of those based on polymers that exhibit electrical conductivity. Lastly, selected works employing sepiolite or palygorskite as fillers in polymeric matrixes of natural origin are discussed, showing the wide application of these resulting nanocomposites as bioplastics, as well as in biomedicine, environmental remediation and the development of sensor devices.
TEMPORAL STABILITY AND FORECASTING ABILITY OF TRIP GENERATION MODELS IN READING (1976)

The paper examines the temporal stability of trip generation models, and the accuracy of current forecasting methods. Three methods were used to explain trip generation. The first adopts the traditional approach of applying multiple regression analysis to explain zonal trips in terms of zonal characteristics. The second method uses the main alternative of category analysis or, more generally, the cross classification of household trip rates. With the growing interest in household regression for conserving the variability of household trip data, the third approach applies regression analysis directly to the household data. All three methods are examined for the degree of representation which they provide at zone level for the temporal stability of the explanation and for the ability of the 1962 mode to produce satisfactory 1971 zonal forecasts. /TRRL/
A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas (2007)

Interleukin-12 (IL-12), a proinflammatory cytokine, shows anticancer properties. Systemically administered IL-12 causes dose-dependent toxicity. To achieve localized intratumoral gene expression, an adenoviral gene therapy vector with IL-12 controlled by a heat-inducible promoter (heat shock promoter 70B) was developed and tested in a phase I clinical trial in cats with spontaneously arising soft tissue sarcoma. A feasibility study was done in 16 cats with soft tissue sarcoma using murine IL-12 and/or enhanced green fluorescent protein adenoviral vectors under cytomegalovirus or heat shock promoter 70 control. Subsequently, we conducted a phase I clinical trial using an adenoviral feline IL-12 construct in 13 cats with soft tissue sarcoma. The soft tissue sarcomas were irradiated (48 Gy/16 fractions) followed by intratumoral injection of adenovirus. Twenty-four hours postinjection, tumors were heated (41 degrees C, 60 min). Tumor expression of feline IL-12 and IFN-gamma was determined. Cats were monitored for systemic toxicity. For the murine IL-12 construct, an association was noted between viral dose and murine IL-12 levels within tumor, whereas serum levels were minimal. Mild toxicity was noted at 10(11) plaque-forming units (pfu). With the feline IL-12 construct, high levels of feline IL-12 mRNA were detected in tumor biopsies with low or absent IFN-gamma mRNA following gene therapy. Hematologic and hepatic toxicities were noted at the highest viral doses and were associated with detection of IFN-gamma mRNA in tumor. It is possible to localize gene expression and limit systemic toxicity of IL-12 using the hyperthermia-induced gene therapy approach. The maximum tolerated dose of the feline IL-12 adenoviral vector was 10(10) pfu/tumor as dose-limiting toxicities were noted at the 4 x 10(10) pfu dose.
Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil (2005)

The prevalence of anti-HCV among this population of volunteer blood donors was 1.7%, and these subjects had few liver histological alterations or chronic hepatitis and cirrhosis. Liver injury severity was significant in patients with elevated ALT, however subjects with normal levels may also present chronic hepatitis and cirrhosis.
Solid Oxide Fuel Cell (SOFC) Development in Denmark (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Arterial and venous plasma catecholamines during submaximal steady‐state exercise (1998)

Arterial and venous plasma catecholamine responses to 15 min of cycling at 60% of maximal oxygen uptake were examined 11 times during exercise and recovery in nine young men. Intra-arterial blood pressure, heart rate and oxygen uptake were recorded continuously. All variables increased significantly during the initial 4 min, after which oxygen uptake, diastolic blood pressure and arterial plasma adrenaline showed no further increase. Heart rate and plasma noradrenaline, however, continued to increase, although significantly more slowly, and were closely correlated (r = 0.81, 95% CI 0.71-0.87), as were systolic blood pressure and heart rate (r = 0.78, 95% CI 0.71-0.87). Venous plasma adrenaline showed a steady increase during the whole exercise period and thus a different response pattern from arterial plasma adrenaline. In conclusion, arterial plasma catecholamines respond to steady-state exercise by a two-phase pattern paralleling the changes in arterial blood pressure and heart rate. Venous sampling does not reveal this association.
The Behavior of <i>Escherichia Coli</i> Endotoxin (Somatic Antigen) during Infectious Arthritis (1963)

Summary On the basis of an immunologic assay method developed with the Boivin endotoxin of E. coli O:113, the behavior of this endotoxin and its antigenic component was studied in animals with septic arthritis produced by the parent organism. A single inoculation of this strain of E. coli into the knee of rabbits established a severe septic arthritis that was accompanied by high spiking fever lasting 2 weeks. Somatic antigen was found in the blood of febrile animals in the absence of bacteremia; this observation indicated that endotoxin was released into the knee by living and dead bacteria in quantities exceeding those that appeared to be bound locally by the articular tissues. In addition to fever, circulating somatic antigen was accompanied by the hematologic changes and immunologic response characteristic of animals given purified endotoxin intravenously and intraarticularly. E. coli was cultured from the knee for 2 weeks. The infectious arthritis was then replaced by a prolonged sterile progressive suppurative arthritis. Because E. coli somatic antigen was demonstrated in the sterile joint fluid and because a similar sterile arthritis with fever was produced by knee injections of endotoxin, it is possible that the endotoxin elaborated by living and dead bacteria was responsible for both the local tissue damage and the systemic effects that occurred during infection. Specific antibody against circulating endotoxin reached its peak at 7 days, whereupon the fever began to decline and further antibody production was checked. Since antisera were found to neutralize both the pyrogenic and antigenic actions of endotoxin, the specific immune response may be partially responsible for interrupting these processes during the infectious arthritis due to E. coli.
Characterization of PSII photochemistry in salt‐adapted cells of cyanobacterium <i>Spirulina platensis</i> (1999)

The changes in pigment composition, photosynthesis and PSII photochemistry were investigated in cells of Spirulina platensis adapted to salt stress (<0.75 M NaCl). A decrease in the phycocyanine/chlorophyll and no significant change in the carotenoid/chlorophyll ratio were observed in salt-adapted cells. Salt stress inhibited the apparent quantum efficiency of photosynthesis and PSII activity while stimulating PSI activity and dark respiration significantly. Salt stress also resulted in a decrease in overall activity of the electron transport chain, which could not be restored by diphenylcarbazide, an artificial electron donor to the reaction centres of PSII. Measurements of the polyphasic fluorescence rise in fluorescence transients including phases O, J, I and P showed that salt stress had no effect on the fluorescence yield at phase O but decreased the fluorescence yield at phases J, I and P. Analyses of the JIP test developed from the polyphasic rise of fluorescence transients showed that salt stress led to a decrease in both the maximum quantum efficiency of PSII photochemistry and the maximum quantum efficiency of electron transport beyond the primary quinone electron acceptor. However, salt stress induced no significant changes in the probability of transporting an electron beyond Q<sub>A</sub> , the trapping flux per PSII reaction centre, or the electron transport flux per PSII reaction centre. A theoretical analysis of fluorescence parameters indicated a decrease in the rate constant of excitation energy trapping by PSII reaction centres. In addition, salt stress induced an increase in the complementary area above the fluorescence induction curve in the presence of 3-(3,4-dichlorophenyl)-1,1-dimethylurea, suggesting an increase in the proportion of closed PSII reaction centres in salt-adapted cells. Based on these results, it is suggested that modifications in PSII photochemistry in salt-adapted Spirulina cells maintained a high conversion efficiency of excitation energy, such that no significant change was observed in either the trapping flux or the electron transport flux per PSII reaction centre.
Probing Molecular Junctions Using Surface Plasmon Resonance Spectroscopy (2006)

The optical absorption spectra of nanometer-thick organic films and molecular monolayers sandwiched between two metal contacts have been measured successfully using surface plasmon resonance spectroscopy (SPRS). The electric field within metal-insulator (organic)-metal (MIM) cross-bar junctions created by surface plasmon-polaritons excited on the metal surface allows sensitive measurement of molecular optical properties. Specifically, this spectroscopic technique extracts the real and imaginary indices of the organic layer for each wavelength of interest. The SPRS sensitivity was calculated for several device architectures, metals, and layer thicknesses to optimize the organic film absorptivity measurements. Distinct optical absorption features were clearly observed for R6G layers as thin as a single molecular monolayer between two metal electrodes. This method also enables dynamic measurement of molecular conformation inside metallic junctions, as shown by following the optical switching of a thin spiropyran/polymer film upon exposure to UV light. Finally, optical and electrical measurements can be made simultaneously to study the effect of electrical bias and current on molecular conformation, which may have significant impact in areas such as molecular and organic electronics.
PERCLOS+: Development of a Robust Field Measure of Driver Drowsiness (2008)

In almost all eukaryotes, mitochondrial (mt) genes are transmitted to progeny mainly from the maternal parent. The most popular explanation for this phenomenon is simple dilution of paternal mtDNA, because the paternal gametes (sperm) are much smaller than maternal gametes (egg) and contribute a limited amount of mitochondria to the progeny. Recently, this simple explanation has been challenged in several reports that describe the active digestion of sperm mtDNA, down-regulation of mtDNA replication in sperm, and proteolysis of mitochondria triggered by ubiquitination. In this investigation, we visualized mt nucleoids in living sperm by using highly sensitive SYBR green I vital staining. The ability to visualize mt nucleoids allowed us to clarify that the elimination of sperm mtDNA upon fertilization is achieved through two steps: (i) gradual decrease of mt nucleoid numbers during spermatogenesis and (ii) rapid digestion of sperm mtDNA just after fertilization. One notable point is that the digestion of mtDNA is achieved before the complete destruction of mitochondrial structures, which may be necessary to avoid the diffusion and transmission of potentially deleterious sperm mtDNA to the progeny.