gebhart/patrepeval huggingface dataset:
Performance of a parallel network backup manager (1992)

The advent of inexpensive multi-gigabyte tape drives has made possible the completely automated backup of many dozens of networked workstations to a single tape. One problem that arises with this scheme is that many computers cannot backup their disks over the network at more than a fraction of the tape&apos;s rated speed. Thus, running overnight backups sequentially can take well into the next day. We have developed a parallel backup manager named Amanda that solves this problem by running a number of backups in parallel to a holding disk, then using a multi-buffer copy scheme to transfer the backups to the tape at the full rated tape speed. Amanda uses accurate estimates of current backup sizes as well as historical information about backup rates so as to schedule backups in parallel without swamping the network or overrunning the holding disk or tape. Locally, we use Amanda to back up 11.5 gigabytes of data in over 230 filesystems on more than 100 workstations, using a single ...
Amplification of a DEAD box protein gene in retinoblastoma cell lines. (1993)

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Here, we report that the mRNA encoding a DEAD box protein, designated HuDBP-RB, is present at elevated levels in two of six retinoblastoma (RB) cell lines tested and is preferentially expressed in fetal tissues of neuroectodermal origin. It is not possible to classify HuDBP-RB as a member of any of the DEAD box protein subgroups identified to date since the regions of amino acid similarity between HuDBP-RB and other DEAD box proteins are restricted to the conserved motifs found in all members of this family. The HuDBP-RB gene, which has been mapped to chromosome band 2p24, is amplified in the RB cell lines that overexpress HuDBP-RB RNA. Furthermore, the MYCN gene is also present in multiple copies in these two cell lines, suggesting coamplification of the two genes.
<i>Mad</i> acts downstream of Dpp receptors, revealing a differential requirement for <i>dpp</i> signaling in initiation and propagation of morphogenesis in the <i>Drosophila</i> eye (1996)

Decapentaplegic (Dpp), a member of the TGF-beta family of cytokines, has been implicated in many patterning processes in Drosophila, including the initial steps of pattern formation in the developing eye. We show that the Mothers against dpp (Mad) gene is required for dpp signaling during eye development. Clonal analysis demonstrates a cell-autonomous function for Mad and genetic interactions indicate that Mad is an essential component of the signal transduction pathway downstream of the Dpp receptors in responding cells. Mad-mediated dpp signaling is absolutely required for the initiation of the morphogenetic furrow in the eye, but has only a minor role in its subsequent propagation across the eye disc. We also present evidence for the repression of wingless transcription by dpp signaling.
Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G (2005)

Taken together, these results demonstrate that palmitate stimulates apoptosis by evoking an intrinsic pathway of proapoptotic signaling and identify mitochondrial release of endonuclease G as a key step in proapoptotic signaling by saturated FFA and in the anti-apoptotic actions of unsaturated FFA.
Role of Interface Contact in CeO<sub>2</sub>–TiO<sub>2</sub>Photocatalytic Composite Materials (2013)

The role of interface contact between two oxides, CeO2 and TiO2, for the photocatalytic elimination of toluene is examined in a series of samples with variable quantities of ceria. Samples having ceria contents in the 1 to 10 mol % range improve significantly, exhibiting up to 3.5 times the activity of the bare nano-TiO2 catalyst. To interpret the photocatalytic behavior, this contribution develops a novel spectro-kinetic approach where a joined analysis of the kinetics of the reaction and the fate of charge charriers is merged with the mathematical modeling of the light–catalyst interaction at the photoreactor. This produces a self-consistent approach that simultaneously validates the kinetic model and interprets the activity on rigorous bases. The study is completed with a multitechnique examination of the solids using X-ray diffraction and electron paramagnetic resonance, UV–vis, and X-ray photoelectron spectroscopies as well as high-resolution transmission electron microscopy. The results provide quantitative evidence that the oxide–oxide contact controls the photoactivity through the number of hole-related species available at the surface of the composite materials and that this number is in turn related to the stabilization of reduced Ce species present at the Ce–Ti interface.
Diagnostic assay and technology advancement for detecting SARS-CoV-2 infections causing the COVID-19 pandemic (2022)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused COVID-19 pandemic has transmitted to humans in practically all parts of the world, producing socio-economic turmoil. There is an urgent need for precise, fast, and affordable diagnostic testing to be widely available for detecting SARS-CoV-2 and its mutations in various phases of the disease. Early diagnosis with great precision has been achieved using real-time polymerase chain reaction (RT-PCR) and similar other molecular methods, but theseapproaches are costly and involve rigorous processes that are not easily obtainable. Conversely, immunoassays that detect a small number of antibodies have been employed for quick, low-cost tests, but their efficiency in diagnosing infected people has been restricted. The use of biosensors in the detection of SARS-CoV-2 is vital for the COVID-19 pandemic's control. This review gives an overview of COVID-19 diagnostic approaches that are currently being developed as well as nanomaterial-based biosensor technologies, to aid future technological advancement and innovation. These approaches can be integrated into point-of-care (POC) devices to quickly identify a large number of infected patients and asymptomatic carriers. The ongoing research endeavors and developments in complementary technologies will play a significant role in curbing the spread of the COVID-19 pandemic and fill the knowledge gaps in current diagnostic accuracy and capacity.
Environmentally Friendly and Highly Sensitive Ruthenium(II) Tris(2,2′‐bipyridyl) Electrochemiluminescent System Using 2‐(Dibutylamino)ethanol as Co‐Reactant (2006)

Electric light orchestra: The electrochemiluminescence (ECL) intensity of the [Ru(bpy)3]2+/2-(dibutylamino)ethanol (DBAE) system at Au and Pt electrodes are about 10 and 100 times, respectively, greater than that of the commonly used [Ru(bpy)3]2+/tripropylamine (TPA) system (see picture). Thus, DBAE is a promising co-reactant for [Ru(bpy)3]2+ ECL immunoassays and DNA probe assays.
Desenvolvimento de um sistema de detecção de instabilidades de plasma para um propulsor a plasma do tipo hall (2009)

The Plasma Laboratory of UnB has been developing a Hall Thruster since 2002. The project consists on the construction and charactrerization of a plasma propulsion engine based on the Hall Effect. This thrusting system is designed to be used in satellite attitude control and long term space missions. A great advantage of this kind of thruster is the production of a steady state magnetic field by permanent magnets providing electral trapping and Hall Current generation within a significant decrease on the energy used and thus turning this thruster into a good option when it comes to space usage. One of the phenomena that may significantly interfere in the device’s performance is the occurrence of instabilities. In this work, we trated the theory of instabilities that can occur inside the Hall channel and, in order to better understand the oscillations that occur during the thruster’s operation we propose the use of a instability detection system based on a RF (radio frequency) detection probe.
Large-Scale Adaptive Hitchhiking Upon High Recombination in <i>Drosophila simulans</i> (2003)

Natural selection is expected to leave a characteristic footprint on neighboring nucleotide variation through the effects of genetic linkage. The size of the region affected is proportional to the strength of selection and greatly reduced with the recombinational distance from the selected site. Thus, the genomic footprint of selection is generally believed to be restricted to a small DNA stretch in normal and highly recombining regions. Here, we study the effect of selection on linked polymorphism (hitchhiking effect) by surveying nucleotide variation across a highly recombining approximately 88-kb genomic fragment in an African population of Drosophila simulans. We find a core region of up to 38 kb with a major haplotype at intermediate frequency. The extended haplotype structure that gradually vanishes until disappearing is unusual for a highly recombining region. Both the presence in the structured genomic domain of a single major haplotype depleted of variability and the detected spatial pattern of variation along the approximately 88-kb fragment are incompatible with neutral predictions in a panmictic population. A major role of demographic effects could also be discarded. The observed pattern of variation clearly provides evidence that directional selection has acted recently on this region, sweeping out variation around a strongly adaptive mutation. Our findings suggest a major role of positive selection in shaping DNA variability even in highly recombining regions.
Cost optimal preventive maintenance and replacement scheduling (1998)

In this paper, we present a method for predicting a cost-optimal preventive maintenance policy for a repairable system with an increasing Rate of Occurrence Of Failure (ROCOF). We segment the maintenance planning horizon into n discrete and equally-sized periods. For each period, we predict which of three possible actions, (maintain the system, replace the system, or do nothing to the system) should be taken, such that the total net present worth of all future costs is minimized. Our model expands upon previous work by utilizing the concept that maintenance reduces the “effective age” of the system and hence the system ROCOF. We develop the model and evaluate three solution procedures, namely, a random search, a genetic algorithm, and a branch-and-bound approach. The entire approach is illustrated through the use of a numerical example.
Retrievable puncture anchor traction method for endoscopic ultrasound-guided gastroenterostomy: A porcine study (2020)

The RPAT method helps reduce mobility of the bowel. Therefore, the RPAT-assisted EUS-GE method is a minimally invasive treatment modality.
The Presence and Absence of Category Knowledge in LSA (2020)

How much information about meaning is contained in the statistical structure of the environment? LSA is a theoretical and practical tool that is challenging previous notions about what is contained in the statistical structure of the environment. This paper examines what kind of category knowledge can be obtained from the environment using LSA. In particular, two experiments are conducted with LSA to test what kind of category structure it embodies. LSA ratings about the relatedness of categories to their properties are compared with human judgments regarding the centrality of properties to the categories. LSA is found to capture aspects of property centrality for some object and event categories. However, it is found to only capture those aspects related to typicality: how often do members of the category have that property? LSA fails to capture other aspects of centrality that can be found in human category judgments. Thus, it appears that humans do bring other constraints to bear in shaping their categories.
Efficient computations in galois fields (1992)

In this dissertation some algorithms and related hardware structures for computing division and multiplication over finite or Galois fields are presented. The structures are regular, which is important for hardware realization, particularly for large finite fields.\nThe concept of supporting elements is introduced which leads to efficient algorithms for computing divisions and multiplications in finite fields. A relationship between systems of linear equations over GF(q) and division in GF [special characters omitted] is established. Using this relationship, a division algorithm valid for any irreducible polynomial or any field basis is presented. It is also proved that if the elements are represented with respect to a canonical basis, then division over GF [special characters omitted] can be performed by solving a discrete time Wiener-Hopf equation over GF(q).\nA bit-serial systolic divider for finite fields of the form GF [special characters omitted] is presented. The divider structure does not depend on the irreducible polynomial defining the field and requires no global data communications. Moreover, the time step duration is independent of the value of m, which is important for large finite fields.\nBy exploiting the structure of a Toeplitz matrix, a bit-serial multiplier applicable to any irreducible polynomial defining the field is presented. The multiplier is efficient in the sense that it requires, in general, less circuitry compared to equivalent existing multipliers.\nFinite fields GF [special characters omitted] generated by irreducible all one polynomials (AOP) and equally space polynomials (ESP) are considered. Algorithms and structures are presented for parallel computation of multiplications in these fields. It is shown that if for a certain degree both an irreducible AOP and ESP exist, it is advantageous to use an ESP based parallel multiplier. Moreover, it is shown that parallel multipliers based on ESP can be obtained by using modules of a corresponding AOP based multiplier.\nFinally, as an application of the efficient bit-serial multiplication algorithm, a Reed-Solomon encoder structure is presented. The structure features simple basis transformation circuitry and supports a variable code rate.
Interactive animation of dynamic manipulation (2006)

Lifelike animation of object manipulation requires dynamic interaction between animated characters, objects, and their environment. These interactions can be animated automatically with physically based simulations but proper controls are needed to animate characters that move realistically and that accomplish tasks in spite of unexpected disturbances. This paper describes an efficient control algorithm that generates realistic animations by incorporating motion data into task execution. The end result is a versatile system for interactive animation of dynamic manipulation tasks such as lifting, catching, and throwing.
Talnetant GlaxoSmithKline. (2005)

Talnetant (SB-223412) is a selective, orally active NK3 antagonist based on 4-quinolinecarboxamide, and is under development by GlaxoSmithKline (formerly SmithKline Beecham) for the potential treatment of several disorders, including urinary incontinence, irritable bowel syndrome and schizophrenia. By November 2004, the compound had completed phase II trials.
Numerical algebraic geometry and algebraic kinematics (2011)

In this article, the basic constructs of algebraic kinematics (links, joints, and mechanism spaces) are introduced. This provides a common schema for many kinds of problems that are of interest in kinematic studies. Once the problems are cast in this algebraic framework, they can be attacked by tools from algebraic geometry. In particular, we review the techniques of numerical algebraic geometry, which are primarily based on homotopy methods. We include a review of the main developments of recent years and outline some of the frontiers where further research is occurring. While numerical algebraic geometry applies broadly to any system of polynomial equations, algebraic kinematics provides a body of interesting examples for testing algorithms and for inspiring new avenues of work.
[Curcuma xanthorrhiza (Java tumeric) in clinical use]. (1996)

The rhizome of Curcuma xanthorrhiza has been used for medical purposes for hundreds of years. A related plant, but which contains other constituents, is C. domestica, which is used in the manufacture of curry powder. Both experimental and clinical studies have revealed, in particular, a choleretic effect. In addition, in part in animal experimental studies, antilipidemic, analgesic-antiphlogistic and antimicrobial effects have also been found.
A Coaxial to Microstrip Transition (Short Papers) (1976)

A method of obtaining an improved transition, from 0.141-in (3.55-mm) semirigid coaxial to microstrip is described. Further improvements by means of compensation include two fixed types having a reflection coefficient less than 0.005 and an adjustable form capable of producing a "transparent" transition.
Developing a market plan— Lessons from the Inn at Plum Greek (1993)

This inside look at an actual marketing plan will show you how to build yours and give you ideas for where to look for business. Only the names have been changed to protect the property
Nonlinear model predictive control of a continuous bioreactor at near-optimum conditions (1998)

The modeling and control of a nonlinear bioreactor system utilizing Volterra-Laguerre models is examined. An analytic solution to the single-input single-output (SISO) unconstrained nominal control problem is described, and a nonlinear model predictive controller (MPC) based on the analytic solution is developed which includes dynamic compensation and manipulated variable weighting. This controller avoids the entrapment in local wells seen in gradient descent nonlinear programming solutions. Additionally, extremum control is performed with no a priori knowledge of the system aside from the identified Volterra-Laguerre representation. In the presence of input magnitude constraints, the analytic controller finds the optimal input move in the feasible region. Initial extensions to the mismatch case are also examined.
Niobium and Aluminum Josephson Junctions Fabricated with a Damascene CMP Process (2012)

We report on the fabrication of Josephson junction and superconducting bridges using a damascene CMP process applied for a first time to superconductors. The demonstrated industrial reliability of damascene CMP processes on large scale semiconductor circuits is a major incentive for our research that should allow large numbers of nanometric Josephson junctions to be fabricated in both Nb and Al, the two main material employed in superconducting quantum computing (qubit) and RSFQ electronics fabrication.We carried out a Chemical-Mechanical Polishing (CMP) process on Nb and Al films deposited on a SiO2 layer patterned with trenches of 100 to 300 nm of nominal depth. The process formed long bridges, 1 to 4 μm wide. The susceptibility and resistive transitions showed that CMP has no observable influence on superconductivity.We have also developed a hybrid technique that uses Al/Al2O3/Al shadow evaporation in the trenches before the damascene CMP process. This allows for high quality “in-situ” junction oxidation with the size reduction benefit provided by the damascene CMP process. We easily reach junctions sizes near 0.5 μm2 which are difficult to fabricate by other methods.We describe these techniques and report on measurements on large bridges and junctions and on the fabrication and measurements of Al and Nb nanobridges.
Virtual private network call processing in the intelligent network (2003)

The author explains the main features of the virtual private network (VPN) and proposes and defines a new integrated service control point call processing design model for the intelligent network. The model allows multiple application services to be executed simultaneously and provides real-time behavior. The features and capabilities of this model of call processing are addressed, and it is applied to the VPN application services.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Solubilization of benomyl for xylem injection in vascular wilt disease control (1971)

Benomyl, in varying amounts, was solubilized in several solvents, thus allowing injection into trees for fungus disease prevention and therapy. A large amount of benomyl can be solubilized in diluted lactic acid. The resulting solution can be infinitely diluted with water without pre-cipitation. These characteristics make it the current solution of choice for our tree injection studies.
A Ubiquitous Context-sensitive Multimodal Multimedia Computing System and Its Machine Learning-based Reconfiguration at the Architectural Level (2006)

In this paper, we present our work on a ubiquitous context-sensitive multimodal multimedia computing system that progressively acquires machine knowledge. This ubiquitous computing system supports an automatic selection of media and modalities deemed appropriate for the user's context and user's profile. The ability of the system to do so constitutes its acquired knowledge. The decision making for media/modality selection takes into account if the user has some special needs due to disability. The architecture of the system is designed to be pervasive and is conceived to resist failure. In case of one or more components being missing or found defective, the machine would resist failure by reconfiguring itself dynamically in the architectural level. It finds alternative replacement to the failed component using its acquired knowledge.
<i>cis</i>-Unsaturated Free Fatty Acids Block Growth Hormone and Prolactin Secretion in Thyrotropin-Releasing Hormone-Stimulated GH<sub>3</sub>Cells by Perturbing the Function of Plasma Membrane Integral Proteins<sup>1</sup> (1997)

In vivo FFA block basal and stimulated GH secretion and have been implicated in the pathogenesis of the altered GH secretion present in obesity and Cushing's syndrome. Although a direct action on the somatotroph cell has been postulated, the FFA mechanism of action is unknown. The main biological target for FFA action is the cellular membrane, and it has been shown that these metabolites can block the activity of a number of plasma membrane pumps, channels, and receptor systems. In the present work, it was observed using different types of pituitary cells (GH3, GH4C1, and rat pituitary primary cultures) that cis-unsaturated fatty acids, such as oleic, 1) do not perturb TRH binding or the homologous desensitization of the TRH receptor; 2) inhibit TRH-induced inositol 1,4,5-trisphosphate/diacylglycerol generation, probably by a direct perturbation of phospholipase C; 3) reduce the TRH-induced intracellular Ca2+ redistribution and the ensuing changes in membrane potential; 4) completely inhibit the [Ca2+]i rise due to the TRH-induced opening of voltage-gated Ca2+ channels; and 5) abolish the TRH-induced Ca2+ efflux through plasma membrane Ca2+ pumps. These results suggest that cis-unsaturated FFA such as oleic acid selectively perturb the function of integral membrane proteins such as enzymes, channels, and pumps without perturbing the binding of ligands to receptors.