gebhart/patrepeval huggingface dataset:
LA RESPUESTA ADAPTATIVA INDUCIDA POR RADIACIÓN Y SUS POSIBLES CAUSAS (2013)

La respuesta adaptativa es un fenomeno que puede ser inducido por la radiacion ionizante, el cual consiste en que laexposicion a dosis bajas de este agente, induce mecanismos mediante los cuales las celulas estan mejor preparadas paraafrontar exposiciones posteriores a dosis mas altas del mismo agente o de otro que dane al ADN. Esta repuesta se inducebajo determinadas condiciones experimentales y depende en gran parte de la constitucion genetica del organismo enestudio. Su induccion se ha explicado en funcion de tres causas principales: induccion de mecanismos de reparacion,estimulacion de sistemas detoxificantes o apoptosis. Existen evidencias que apoyan a estas alternativas, aunque laregulacion aun no es del todo comprendida. Es probable que no solo un mecanismo este involucrado, sino que sea elresultados de una serie de eventos relacionados. La motivacion para continuar con este tipo de estudios se basa, tanto enel deseo de comprender los mecanismos basicos que participan en su induccion y regulacion como para conocer si estefenomeno afecta la estimacion del riesgo de exposicion a dosis bajas de radiacion, en la incidencia de mutacion y canceren las poblaciones humanas.
Collagen-induced arthritis in the rhesus monkey : relations between aspects of autoimmunity and disease development (1992)

CHAPTER 1 General introduction 1.1 The relevance of an arthritis model in the rhesus monkey 1.2 Spontaneous arthritic manifestations in nonhuman primates 1.3 Experimentally induced arthritis in nonhuman primate species 1.4 Type n collagen 1.5 Type II collagen inununity in humans 1.6 Type II collagen induced arthritis in rodents 1.7 Aim of the study CHAPTER 2 Experimental immune mediated arthritis in rhesus monkeys.A model for human rheumatoid arthritis?CHAPTER 3 Collagen induced arthritis in an outbred group of rhesus monkeys comprising responder and non-responder animals.Relation between the course of arthritis and collagen-specific immimity.CHAPTER 4 Induction of type II collagen-specific antibody production in blood lymphocyte cultures of rhesus monkeys (Macaca mulatta) with collageninduced arthritis using the immobilized native antigen.CHAPTER 5 Acquired resistance to type II collagen induced arthritis in rhesus monkeys is reflected by a T cell low-responsiveness to the antigen.
Biosynthesis and disulfide cross-linking of outer membrane components during the growth cycle of Chlamydia trachomatis (1987)

The synthesis and accumulation of Chlamydia trachomatis outer membrane proteins within infected HeLa 229 host cells were monitored by assessing the uptake of [35S]cysteine into chlamydial proteins during the 48-h growth cycle of a lymphogranuloma venereum strain, L2/434/Bu. Synthesis of the major outer membrane protein, a protein that accounts for about 60% of the outer membrane protein mass of elementary bodies (EB), was first detected between 12 and 18 h after infection. The uptake of [35S]cysteine into the 60,000-molecular-weight doublet (60K doublet) and 12.5K cysteine-rich proteins was not observed until 30 h after infection, when the intracellularly dividing reticulate bodies were beginning to transform into infectious EBs. By using a more sensitive immunoblotting method in conjunction with monoclonal antibodies specific for the 60K doublet proteins, synthesis of these proteins was detected even earlier, by 18 h after infection. These data suggest that the time and extent of synthesis of these outer membrane proteins are regulated by processes that coincide in time with the transformation of reticulate bodies into EBs. Additional studies were performed to determine the extent of disulfide cross-linking of outer membrane proteins during the growth cycle. Both the major outer membrane protein and the 12.5K protein became progressively cross-linked to about 60% during the last 24 h of the growth cycle, whereas the 60K doublet proteins were extensively cross-linked during most of the cycle. These data may indicate an intracellular cross-linking mechanism, possibly enzymatic, that exists in addition to an auto-oxidation mechanism that occurs upon host cell lysis and exposure to the extracellular environment.
VIBRATION ARTHROGRAPHY IN THE DIAGNOSIS OF INTERNAL DISEASE OF THE KNEE (1985)

In this paper, the principles of vibration arthrography are briefly described and the analysis of the resulting signals is explained. Using such a system, localisation of signals from within the joint is possible. Finally, the development of a vibration-based arthrographic system is proposed as a safe, relatively inexpensive, and totally non-invasive aid to the diagnosis of internal disease of the knee.PMID: 3984463 [PubMed - indexed for MEDLINE]
TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation (2012)

Inflammation is a part of the body's natural response to tissue injury which initiates the healing process. Unfortunately, inflammation is frequently painful and leads to hypersensitivity to mechanical stimuli, which is difficult to treat clinically. While it is well established that altered sensory processing in the spinal cord contributes to mechanical hypersensitivity (central sensitization), it is still debated whether primary afferent neurons become sensitized to mechanical stimuli after tissue inflammation. We induced inflammation in C57BL/6 mice via intraplantar injection of Complete Freund's Adjuvant. Cutaneous C fibers exhibited increased action potential firing to suprathreshold mechanical stimuli. We found that abnormal responses to intense mechanical stimuli were completely suppressed by acute incubation of the receptive terminals with the TRPA1 inhibitor, HC-030031. Further, elevated responses were predominantly exhibited by a specific subgroup of C fibers, which we determined to be C-Mechano Cold sensitive fibers. Thus, in the presence of HC-030031, C fiber mechanical responses in inflamed mice were not different than responses in saline-injected controls. We also demonstrate that injection of the HC-030031 compound into the hind paw of inflamed mice alleviates behavioral mechanical hyperalgesia without affecting heat hyperalgesia. Further, we pharmacologically anesthetized the TRPA1-expressing fibers in vivo by co-injecting the membrane-impermeable sodium channel inhibitor QX-314 and the TRPA1 agonist cinnamaldehyde into the hind paw. This approach also alleviated behavioral mechanical hyperalgesia in inflamed mice but left heat hypersensitivity intact. Our findings indicate that C-Mechano Cold sensitive fibers exhibit enhanced firing to suprathreshold mechanical stimuli in a TRPA1-dependent manner during inflammation, and that input from these fibers drives mechanical hyperalgesia in inflamed mice.
Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification (1998)

Human serum paraoxonase (PON1) associated with high density lipoprotein (HDL) has been postulated to have a role in protecting low density lipoprotein (LDL) against oxidative modification, which has led to the proposal that PON1 is an anti-atherogenic, anti-inflammatory enzyme. PON1 has two genetically determined polymorphic sites giving rise to amino-acid substitutions at positions 55 (L-->M) and 192 (R-->Q) and therefore 4 potential alloenzymes. We have examined the effects of these molecular polymorphisms on the ability of HDL to protect LDL from oxidative modification. HDL protected LDL from oxidative modification, whatever the combination of PON1 alloenzymes present in it. However, HDL from QQ/MM homozygotes was most effective at protecting LDL while HDL from RR/LL homozygotes was least effective. Thus after 6 h of co-incubation of HDL and LDL with Cu2+ PON1-QQ HDL retained 57 +/- 6.3% of its original ability to protect LDL from oxidative modification, while PON1-QR HDL retained less at 25.1 +/- 4.5% (P < 0.01) and PON1-RR HDL retained only 0.75 +/- 0.40% (P < 0.005). In similar experiments HDL from LL and LM genotypes retained 21.8 +/- 7.5% and 29.5 +/- 6.6% (P = NS), respectively, of their protective ability, whereas PON1-MM HDL maintained 49.5 +/- 5.3% (P < 0.01). PON1 polymorphisms may affect the ability of HDL to impede the development of atherosclerosis and to prevent inflammation.
The Development of Variable-Step Symplectic Integrators, with Application to the Two-Body Problem (1993)

The authors develop and test variable step symplectic Runge–Kutta–Nyström algorithms for the integration of Hamiltonian systems of ordinary differential equations. Numerical experiments suggest that, for symplectic formulae, moving from constant to variable stepsizes results in a marked decrease in efficiency. On the other hand, symplectic formulae with constant stepsizes may outperform available standard (nonsymplectic) variable-step codes. For the model situation consisting in the long-time integration of the two-body problem, our experimental findings are backed by theoretical analysis.
Multidisciplinary Design of S-Shaped Intake (2008)

Because it is multi-objective and multidisciplinary in nature, designing of intake is one of the most demanding tasks. For the first time, this study investigates a design strategy of combining possible multidisciplinary techniques for achieving desirable design of intake with considering both its aerodynamic (AE) and electromagnetic (EM) performances. To facilitate the geometry parameterization of an intake, Hicks-Henne functions are used as basis functions to formulate the variations of centre line, cross-sectional area and aspect ratio. As an attempt, the gappy proper orthogonal decomposition (POD) method is applied for shape optimization to produce optimal solution in a least square sense. Utilizing this strategy, two redesigned S-shaped intakes are proposed based on a baseline duct. The first one tries to improve only the AE performance of baseline intake, while the second one aims at enhancing both its AE and EM performances. The comparisons between these two redesigned intakes indicated that the result of multidisciplinary design is a compromise solution, due to the conflicting requirements from the viewpoints of AE and EM. Nomenclature DC(θ) = a measure of the flow kinetic energy related to distortion severity, f f q
Engineering Transport Protein Function: Theoretical and Technical Considerations Using the Sugar-Transporting Phosphotransferase System of <i>Escherichia coli</i> as a Model System (2006)

Potential experimental approaches for developing and applying protein-engineering protocols to transmembrane transport systems are described. We specifically consider procedures designed to alter protein function. These procedures are designed for the specific purposes of (1) changing protein interaction specificities and (2) changing a protein's catalytic function. We use sugar-transporting bacterial phosphotransferase systems as model systems to illustrate the proposed approaches. These and other similar procedures are likely to prove to be of utility for biotechnological manipulation of proteins as well as for elucidating potential evolutionary pathways taken for the appearance of novel functions within a protein family.
Small-Intestinal Bacterial Overgrowth in Patients with Liver Cirrhosis, Diagnosed with Glucose H<sub>2</sub>or CH<sub>4</sub>Breath Tests (1998)

We conclude that the prevalence of SIBO in cirrhotic patients is approximately 35.6% and that it is related to the severity of liver disease. There was no difference among various causes of cirrhosis, such as viral, alcoholic, or idiopathic.
The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome (2020)

The relationship between diet and the diversity and function of the intestinal microbiome and its importance for human health is currently the subject of many studies. The type and proportion of microorganisms found in the intestines can determine the energy balance of the host. Intestinal microorganisms perform many important functions, one of which is participation in metabolic processes, e.g., in the production of short-chain fatty acids-SCFAs (also called volatile fatty acids). These acids represent the main carbon flow from the diet to the host microbiome. Maintaining intestinal balance is necessary to maintain the host's normal health and prevent many diseases. The results of many studies confirm the beneficial effect of probiotic microorganisms on the balance of the intestinal microbiome and produced metabolites, including SCFAs. The aim of this review is to summarize what is known on the effects of probiotics on the production of short-chain fatty acids by gut microbes. In addition, the mechanism of formation and properties of these metabolites is discussed and verified test results confirming the effectiveness of probiotics in human nutrition by modulating SCFAs production by intestinal microbiome is presented.
Import of Nuclear DNA-Encoded RNAs into Mitochondria and Mitochondrial Translation (2007)

Targeting nuclear DNA-encoded tRNA into mitochondria is a quasi-ubiquitous process, found in a variety of species, although the mechanisms of this pathway seem to differ from one system to another. In all cases reported, this import concerns small non-coding RNAs and the vast majority of imported RNAs are transfer RNAs. If was commonly assumed that the main criterion to presume a tRNA to be imported is the absence of the corresponding gene in mitochondrial genome, in some cases the imported species seemed redundant in the organelle. By studying one of such "abnormal" situation in yeast S. cerevisiae, we discovered an original mechanism of conditional regulation of mitochondrial translation exploiting the RNA import pathway. Here, we provide an outline of the current state of RNA import in yeast and discuss the possible impact of the newly described mechanism of translational adaptation.
Studies On Characterization Of Corn Cob Based Nanoparticles (2010)

Corn cobs (central part of maize) are either treated as waste or burnt as fuel causing environmental concern. In order to achieve its value addition in new research areas, corn cob can be processed chemically to find ways to generate new end products with added values at very low price. Cellulose-based nanoparticles (CPNs) have an ability to remain intact in stomach environment and small intestine together with the presence of specific enzymes produced by cellulytic bacteria (ruminococus) for colon biodegradability and makes this biopolymer a suitable raw material for the biomedical field, particularly as a colon-specific drug carrier. Cellulose-based nanoparticles (CPNs) were prepared from corn cob raw material by treating it with sodium hydroxide in the range 0-24% of sodium hydroxide concentration, oven dry basis at 165oC for 1.5 h at liquor to solid ratio of 4.5:1. The sample obtained at the optimised condition (18% NaOH concentration, oven dry basis of raw materials) was washed with deionised water, disintegrated and filtered through 80 mesh screens. Powder thus obtained was delignified by acidified sodium chlorite and dried in a vacuum oven to constant weight. Dried powder was further separated by 270 mesh screens. An average particle size approximately equal to 22 nm was obtained by using Transmission Electron Microscopy (TEM). Its crystallinity, functional group and agglomerated particle size was determined by X-ray Diffraction (XRD), Fourier Transform Infrared (FT-IR) and Scanning Electron Microscopy (SEM) techniques respectively.
OUR GROWING UNDERSTANDING OF THYROID FUNCTION AND ITS CLINICAL APPLICATION (1957)

Article1 November 1957OUR GROWING UNDERSTANDING OF THYROID FUNCTION AND ITS CLINICAL APPLICATIONJ. HOWARD MEANS, M.D., F.A.C.P.J. HOWARD MEANS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-5-853 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is a great pleasure, ladies and gentlemen, for me to address the College once more on a subject long dear to me—the thyroid. The justification for attempting so comprehensive an approach in so short a time is that, because I am older than most of you, I can perhaps give a perspective in depth which those of you who have come into the field more recently cannot have got by personal experience.As far as I can recall, I first met the thyroid when I was a freshman in Harvard College in 1904. In an elementary course in anatomy,...Bibliography1. Nièpce B: Traité du goitre et du crétinisme. Suivi de la statistique des goîtreux et des crétin dans le bassin de l'Isère en Savoie, dans les départments de l'Isère, des Hautes-Alpes et des Basses-Alpes, 1851, J. B. Baillière, Paris. Google Scholar2. Salter WT: The endocrine function of iodine, 1940, Cambridge, Harvard University Press. CrossrefGoogle Scholar3. RawsonGrahamRiddell RWRMCB: Physiological reactions of the thyroid stimulating hormone of the pituitary, Ann. Int. Med. 19: 405, 1943. LinkGoogle Scholar4. HaringtonBarger CRG: Chemistry of thyroxine. III. Constitution and synthesis of thyroxine, Biochem. J. 21: 456, 1927. Google Scholar5. GrossPitt-Rivers JR: 3:5:3′ Triiodothyronine; isolation from the thyroid gland and synthesis, Biochem. J. 53: 652, 1953. CrossrefMedlineGoogle Scholar6. Pitt-Rivers R: Physiological activity of the acetic acid analogues of some iodinated thyronines, Lancet 2: 234, 1953. CrossrefGoogle Scholar7. Goetsch E: Functional significance of mitochondria in toxic thyroid adenomata, Bull. Johns Hopkins Hosp. 27: 192, 1916. Google Scholar8. Means JH: The thyroid and its diseases, 2nd Ed., 1948, J. B. Lippincott Co. Philadelphia. Google Scholar9. StanburyMcGirr JBEM: Sporadic or non-endemic familial cretinism with goiter, Am. J. Med. 22: 712, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 12, 1957.Requests for reprints should be addressed to J. Howard Means, M.D., 60 Mount Vernon Street, Boston 8, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFactors which influence the radioactive iodine thyroidal uptake test 1 November 1957Volume 47, Issue 5Page: 853-860KeywordsThyroidThyroid hormones ePublished: 1 December 2008 Issue Published: 1 November 1957 Copyright & PermissionsCopyright ©, 1957, by The American College of PhysiciansPDF downloadLoading ...
An analysis of Bennett's pebble game (1995)

Bennett's pebble game was introduced to obtain better time/space tradeoffs in the simulation of standard Turing machines by reversible ones. So far only upper bounds for the tradeoff based on the pebble game have been published. Here we give a recursion for the time optimal solution of the pebble game given a space bound. We analyze the recursion to obtain an explicit asymptotic expression for the best time-space product.
Mobilization of heavy metals from mine spoils in a part of Raniganj coalfield, India: Causes and effects (2004)

A part of Raniganj coalfield, eastern India, covering an area of about 156 km 2 (60 mi 2 ), was studied to identify the impact of mining on geoenvironment, in terms of heavy-metal mobilization. Twenty-eight soil samples were taken from four major landuse classes, viz., mining area, land with or without scrub, agricultural field, and social forestry area, and analyzed for pH, electrical conductivity, organic carbon, and heavy metals (Fe, Mn, Zn, Cu, Ni, Co, Cr, Pb, Cd, and As). Intermediate groundwater flow system of the area was inferred through the fitting of polynomial trend surfaces to the water-table elevation data from 55 observation wells for premonsoon, monsoon, and postmonsoon periods. Quantitative analyses of 17 groundwater samples (7 from mining areas and 10 from nonmining areas) were carried out with special reference to heavy metals (Fe, Mn, Zn, Cu, Ni, Co, Cr, Pb, Cd, and As) during these three periods. Twigs of selected planted species used in reclamation of one of the mine spoils in the area were also analyzed for heavy metals (Fe, Mn, Zn, Cu, Ni, Co, Cr, Pb, Cd, and As). Impacts of mining have been measured in terms of erosion and heavy-metal mobilization from mine spoils to the surrounding geoenvironment. Leaching on mine spoils followed by surface runoff contaminated the soil with heavy metals, whereas leaching followed by percolation contaminated the groundwater with heavy metals. Effects were inferred in terms of changing ecosystem. Native plant species like Shorea robusta , Terminalia tomentosa , etc. are being replaced by smaller species like Butea monosperma , which appears to be more tolerant in this changed ecosystem.
Factors Leading to Successful Workplace Integration of Employees Who Have Experienced Mental Illness (2005)

Abstract This article reports the findings from a survey of Canadian employers conducted to assess their responses in the development of an inclusive and supportive workplace for employees returning after a prolonged absence due to mental illness. To minimize costs and maximize productivity for companies it was found that employers typically manage employee absence in four ways: information concerning workplace absence, intervention strategies to prevent the absence, absence management and a planned and structured return-to-work program.
deng chuan hei bai hua nai niu tong qi fa qing ji pei tai yi zhi shi yan bao gao (2014)

邓川黑白花奶牛是云南省地方品种,该品种是在20世纪50年代开始,以当地乳用黄牛品种邓川牛为母本,引入黑白花奶牛种公牛,开展杂交改良,经过不断选育而成.邓川黑白花奶牛存栏在15万头左右,中国西部地区多数奶牛都含其血液成分.牛胚胎移植是一项新的育种技术,是快速提高良种化的很好途径.尽管奶牛胚胎移植推广多年,但基层畜牧兽医部门能够掌握该项技术的人员较少,特别县、乡两级尤为突出,影响了奶牛胚胎移植的推广应用.
Csrgan: Medical Image Super-Resolution Using A Generative Adversarial Network (2020)

Super-resolution medical image is vital for doctor’s diagnosis and quantitative analysis. In this work we propose a novel super-resolution generative adversarial network which combine conditional GAN (CGAN) and SRGAN, refer to it as CSRGAN to generate super-resolution (SR) images. We use differential geometric information including Jacobian determinant (JD) and curl vector (CV) as conditional inputs of both the discriminator and generator of SRGAN, which make full use of the idea of using GANs to learn a mapping from one manifold to another. In addition, we proposed a content loss motivated by CV feature information instead of VGG loss in SRGAN. We trained our model on a large-scale dataset CelebFaces Attributes, tested it on medical ultrasound image dataset. The experimental results show the method can achieve better performance in SR image generation with higher average peak signal-tonoise ratio (PSNR), Structural Similarity (SSIM) and Mean Opinion Score (MOS) compared with SRGAN.
A low rank model based improved eye detection under spectacles (2016)

Eye detection is a primary step in many applications such as face recognition, iris recognition, driver fatigue detection, gaze tracking etc. Occlusion by spectacles, glare and secondary image formations deteriorate its performance. In this paper, we formulate the glare/reflection removal as a classification problem and employ Low rank decomposition technique to overcome these challenges. We provide an in-depth analysis by comparing various low rank decomposition formulations and propose a simple preprocessing step to improve the detection accuracy. Experimentation on CASIA NIR-VIS 2.0 facial database validates the proposed preprocessing method.