gebhart/patrepeval huggingface dataset:
Immunochemical and Mutational Analyses of P-type ATPase Spf1p Involved in the Yeast Secretory Pathway (2001)

The yeast SPF1 gene encodes a novel P-type ATPase, the substrate of which specificity has not been identified. It is required for sensitivity to SMKT, a killer toxin produced by the halotolerant yeast Pichia farinosa. To investigate the function of Spf1p, Asp487, the putative phosphorylation site of Spf1p, was replaced by Asn. Expression of the altered SPF1, with Asp487 replaced by Asn, did not suppress the SMKT-resistant phenotype of spf1 mutants, suggesting that the catalytic activity of this ATPase is required for acquisition of sensitivity to SMKT. Subcellular fractionation experiments indicated that the fractionation pattern of Spf1p was similar to that of an early Golgi protein, Och1p. Cells lacking Spf1p had an abnormal fractionation pattern of Sec12p. The spf1 disruptant also showed increased expression of Kar2p and sensitivity to tunicamycin. The glycosylation-defective phenotype and possible role of Spf1p in the secretory pathway are discussed.
A Molecular Switch and Proton Wire Synchronize the Active Sites in Thiamine Enzymes (2004)

Thiamine diphosphate (ThDP) is used as a cofactor in many key metabolic enzymes. We present evidence that the ThDPs in the two active sites of the E1 (EC 1.2.4.1) component of the pyruvate dehydrogenase complex communicate over a distance of 20 angstroms by reversibly shuttling a proton through an acidic tunnel in the protein. This “proton wire” permits the co-factors to serve reciprocally as general acid/base in catalysis and to switch the conformation of crucial active-site peptide loops. This synchronizes the progression of chemical events and can account for the oligomeric organization, conformational asymmetry, and “ping-pong” kinetic properties of E1 and other thiamine-dependent enzymes.
Role and Regulation of Glucose Metabolism in Proliferating Cells (1979)

The history of the interest in glucose metabolism in malignantly transformed cells dates back to the pioneering studies of Warburg. These studies led to the statement, in 1956: “The era in which the fermentation of cancer cells, or its importance, could be debated is over and no-one today can doubt that we understand the origin of cancer cells if we know how their large fermentation originates, or to express it more fully, if we know how the damaged respiration and the excessive fermentation of cancer cells originates.” Even at this time, doubts were expressed about the respiratory deficiency of tumor cells.
Secure communication in cognitive radio networks (2009)

Support for various multimedia applications in wireless networks demands additional bandwidth in the radio frequency spectrum. Efficient spectrum management algorithms are necessary to achieve immense success in wireless communications. Cognitive radio seems to be a panacea for increased utilization of licensed spectrum. It is defined as the new state of art technique that opportunistically share the licensed spectrum while imposing minimum interference to the licensed users. In this paper, we explore the adaptive characteristics of cognitive radio in secure and reliable communication. But the question is how to make the communication reliable such that there occurs no eavesdropping and information leakage. The possible solutions include integrating the merits of spread spectrum modulation, using encryption algorithms (public key and private key encryption), and its potential to switch over various frequency bands. In this paper, we focus on the various applications of cognitive radio and the numerous methodologies which enable a secure communication network.
Remembering the Past and Struggling for Justice: The Contested Legacy of Authoritarian Rule in Chile (2011)

A review of: Battling for Hearts and Minds: Memory Struggles in Pinochet’s Chile, 1973-1988. Vol. 2 of The Memory Box of Pinochet’s Chile. By Steven J. Stern. Durham, NC: Duke University Press, 2006. 247pp. and Remembering Pinochet’s Chile: On the Eve of London 1998. Vol. 1 of The Memory Box of Pinochet’s Chile. By Steven J. Stern. Durham, NC: Duke University Press, 2004. 538pp. and The Pinochet Effect: Transnational Justice in the Age of Human Rights. By Naomi Roht-Arriaza. Philadelphia: University of Pennsylvania Press, 2005. 256pp.
Statistical debugging using compound boolean predicates (2007)

Statistical debugging uses dynamic instrumentation and machine learning to identify predicates on program state that are strongly predictive of program failure. Prior approaches have only considered simple, atomic predicates such as the directions of branches or the return values of function calls. We enrich the predicate vocabulary by adding complex Boolean formulae derived from these simple predicates. We draw upon three-valued logic, static program structure, and statistical estimation techniques to efficiently sift through large numbers of candidate Boolean predicate formulae. We present qualitative and quantitative evidence that complex predicates are practical, precise, and informative. Furthermore, we demonstrate that our approach is robust in the face of incomplete data provided by the sparse random sampling that typifies postdeployment statistical debugging.
Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains. (1993)

Using cDNA subtraction and differential hybridization techniques, a cDNA library derived from normal quail embryo fibroblasts was screened for clones corresponding to genes whose expression was suppressed in v-myc-transformed, as compared with normal, quail embryo fibroblasts. One of the isolated cDNA clones corresponded to a 0.9-kb mRNA that was present in normal quail and chicken embryo fibroblasts, but was virtually absent from all transformed avian cells tested: quail embryo fibroblasts transformed by the v-myc, v-myc/v-mil or v-src oncogenes, cells derived from a methylcholanthrene-induced quail fibrosarcoma or v-myc-transformed chicken macrophages. Nucleotide sequence analysis of the original and supplementary cDNA clones indicated that the corresponding gene encodes a 194 amino acid cysteine-rich protein (M(r) 20,911). A database search revealed that the gene is the avian homolog of a human primary response gene (crp) of unknown function. Both the quail and human CRP proteins contain two copies of a cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity that was previously identified in several proteins with presumed regulatory functions essential for cell growth or differentiation.
Value of CT and MRI in the diagnosis of leukoaraiosis (2008)

Objective To evaluate the value of CT and MRI in the diagnosis of leukoaraiosis(LA)and to analyze its CT and MRI findings.Methods One hundred and twenty patients with neuropathic symptom were examined by both CT and MRI in last year.Their CT images were compared with MR images.Results LA lesions mainly located in the subcortex white matter,semioval center,white matter around the lateral cerebral ventricles,and/or in the deep part.LA lesions displayed as symmetrical low density shadows on CT images,while as irregular,ill-defined dotty,patchy iso-or low-T1 signal density and high T2 signal density on MR images.It was often accompanied by multifocal cerebral infarctions and atrophy or other cerebrovascular diseases.It also occurred in the normal aged people.Conclusion Leukoaraiosis shows characteristic appearance on CT and MR images.Spiral CT is valuable in the diagnosis of LA,as well as economical and easily manipulated.MRI displays more lesions and so is more sensitive,especially using T2 flair series.MRI may be the first choice for the diagnosis of LA when it is available.
On the Preferred Dissolution of Iron from Thin Films of Permalloy (1985)

Etude de la dissolution preferentielle lorsque l'on dissout des couches minces d'alliage Fe-Ni dans un bain d'attaque en circuit ouvert. Mesure du potentiel en circuit ouvert pour des films de diverses epaisseurs
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy (2017)

Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throughout the contractile system despite the ongoing muscle remodeling that occurs with muscle atrophy, damage and aging. We uncovered an essential role for autophagy in T-tubule remodeling with genetic screens of a developmentally regulated remodeling program in Drosophila abdominal muscles. Here, we show that autophagy is both upregulated with and required for progression through T-tubule disassembly stages. Along with known mediators of autophagosome-lysosome fusion, our screens uncovered an unexpected shared role for Rab2 with a broadly conserved function in autophagic clearance. Rab2 localizes to autophagosomes and binds to HOPS complex members, suggesting a direct role in autophagosome tethering/fusion. Together, the high membrane flux with muscle remodeling permits unprecedented analysis both of T-tubule dynamics and fundamental trafficking mechanisms.
Relaying a fountain code across multiple nodes (2008)

Fountain codes are designed for erasure channels, and are particularly well suited for broadcast applications from a single source to its one hop receivers. In this context, the problem of designing a rateless code in the network case for on-the-fly recoding is very important, as relaying the data over multiple nodes is fundamentally useful in a network. Clearly, fountain codes are unsuited for on-line recoding (and simply forwarding over subsequent hops is provably suboptimal). Random linear codes are throughput optimal, but they do not enjoy the low complexity that is a prime feature of fountain codes. Can we get the low complexity of say, LT codes, while maintaining on-the-fly recoding and being throughput optimal? This paper proposes a novel solution to the above question. We consider packet level coding on a line network of discrete memoryless erasure channels (with potentially unlimited nodes), and exhibhit a coding scheme with (1) tatelessness (2) logarithmic per-symbol coding complexity (3) throughput optimality (achieves rates equal the min cut capacity) and (4) avoids the delay of having to decode and then re-encode entire block lengths at intermediate nodes.
Etching of Lithium Niobate: From Ridge Waveguides to Photonic Crystal Structures (2008)

Abstract. Recent progress of wet etching of Z-cut LN, of inductively coupled plasma (ICP-) etching of X-cut LN, and of ICP-etching of proton-exchanged X-cut LN is reported to fabricate low loss ridge guides, micromechanical, and photonic crystal structures.
Knowledge acquisition to facilitate organizational problem solving (1990)

Article Free Access Share on Knowledge acquisition to facilitate organizational problem solving Authors: Angeliki Poulymenakou Information Systems Department, London School of Economics and Political Science, Houghton Street, London WC2A 2AE Information Systems Department, London School of Economics and Political Science, Houghton Street, London WC2A 2AEView Profile , Tony Cornford Information Systems Department, London School of Economics and Political Science, Houghton Street, London WC2A 2AE Information Systems Department, London School of Economics and Political Science, Houghton Street, London WC2A 2AEView Profile , Edgar A. Whitley Information Systems Department, London School of Economics and Political Science, Houghton Street, London WC2A 2AE Information Systems Department, London School of Economics and Political Science, Houghton Street, London WC2A 2AEView Profile Authors Info & Claims SIGBDP '90: Proceedings of the 1990 ACM SIGBDP conference on Trends and directions in expert systemsSeptember 1990 Pages 181–188https://doi.org/10.1145/97709.97724Published:01 September 1990Publication History 0citation589DownloadsMetricsTotal Citations0Total Downloads589Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
SPECT deadtime count loss correction using monitor source method (2014)

Purpose: Deadtime-count-loss (DTloss) correction using monitor source (MS) requires: 1) uniform fractional DTloss across FOV, 2) high statistics MS images both with & without the object. The aims are validating condition 1 and developing a practical protocol that satisfies conditions 2 with minimal additional study duration. Methods and Materials : SPECT images of non-uniform phantoms (4GBq 99mTc) along with MS (20MBq 99mTc) attached to each detector were acquired multiple times over 48 hours in photopeak and scatter energy window (EW) using Siemens-SymbiaS and GE-D670. Planar images of the MS alone were acquired. Photopeak counts for the MS ROIs were > 100kcts. Fractional DTloss uniformity across the FOV was evaluated by correlating count rates in different ROIs on projection images at different DTloss levels. The correction factor for each SPECT projection at every time point was calculated as the ratio of time-corrected MS count rates with & without the phantom. The DTloss-corrected projections for each SPECT acquisition were decay corrected to one time point. The correction accuracy was assessed against DTloss estimated by paralyzable model. The accuracy of projection-based DTloss correction for SPECT was evaluated. A method to model projection DTloss based on a subset of measured projection DTloss was investigated. The relation of DTloss between photopeak and scatter EW was explored. Results: The fractional DTloss was uniform across the FOV (r > 0.99), validating condition 1. The MS method was accurate to > 99% for planar and SPECT. Measured DTloss from 3-to-5 projections/detector may be used to estimate DTloss with accuracy > 98% for all SPECT projections by modeling DTloss with measured projection rate. The correction factor in photopeak and scatter EW are equivalent with > 99% agreement. Conclusion : MS method can accurately correct planar and SPECT DTloss. Sparse sampling of the projection DTloss allows acquiring MS counts with high statistics with minimal additional study duration making it clinically practical. -------------------------------------- Cite this article as: Siman W, Kappadath SC. SPECT deadtime count loss correction using monitor source method. Int J Cancer Ther Oncol 2014; 2(2):020234. DOI: 10.14319/ijcto.0202.34
Small‐size printed loop antenna for penta‐band thin‐profile mobile phone application (2009)

Abstract A planar printed loop antenna with a small area of 15 × 50 mm 2 and capable of covering all five operating bands of GSM850/900/1800/1900/UMTS for WWAN (wireless wide area network) operation in the thin‐profile mobile phone is presented. The antenna is very suitable to be directly printed on the system circuit board of the mobile phone, making it easy to fabricate at low cost and generally showing no thickness above the circuit board; the latter is very attractive for thin‐profile mobile phone applications. In addition, the proposed loop antenna is very suitable to be printed at the bottom position of the mobile phone; in this case the antenna meets the SAR (specific absorption rate) limit for practical applications. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1512–1517, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24359
Multiregion Short-Term Load Forecasting in Consideration of HI and Load/Weather Diversity (2010)

The ultimate goal of an electric utility is to create maximum profit while maintaining reliability and security of the power supply. The operation and control of power system is sensitive to system demand. Therefore, improvements in load-forecasting accuracy will lead to cost savings and enhance system security. Due to Taiwan's distinct climate characteristics, it is difficult to obtain satisfactory load-forecasting results by treating the whole island as a single region. In addition, weather factors, such as temperature, relative humidity, and the Heat Index (HI) (a human-perceived equivalent temperature) may also affect load-consumption patterns. This paper proposes a multiregion short-term load-forecasting methodology, taking into account the HI to improve load-forecasting accuracy in Taiwan Power Company's (Taipower's) system. The results show that adopting the HI as a parameter can effectively improve the accuracy if the temperature of the region under investigation is above 27°C (80°F). By considering both the load/weather diversity and the HI, further improvements to the load forecasting for the Taipower system during summer can be achieved.
A System for Preparing and Distributing Large Volumes (1968)

A systein for preparing and distributing 100 liters of distilleddeionized water per day is described. Novel features are an overflow regulator, a " barometer " tube (permitting secondary reservoirs), and a pressure-controlled shutoff valve.
Role of 5‐ht<sub>7</sub> receptors in the long‐lasting hypotensive response induced by 5‐hydroxytryptamine in the rat (1997)

1. The receptor mediating the long-lasting hypotensive effect of intravenous (i.v.) 5-hydroxytryptamine (5-HT) in the rat was originally classified as 5-HT1-like. Since some pharmacological properties of this receptor are closely similar to those for the cloned 5-ht7 receptor, the present study investigated the effects of several 5-HT receptor agonists and antagonists showing high affinity for the cloned 5-ht7 receptor in pithed rats with artificially raised blood pressure. 2. I.v. bolus administration of 5-HT, 5-carboxamidotryptamine (5-CT), 5-methoxytryptamine, lisuride and sumatriptan to bilaterally vagotomized pithed rats pretreated with ketanserin (0.18 mumol kg-1, i.v.), the diastolic blood pressure of which had been raised by a continuous i.v. infusion of methoxamine (60-80 nmol kg-1 min-1), produced dose-dependent hypotensive responses; only 5-HT and 5-CT displayed similar maximum effects. In addition to mimicking the hypotensive action of 5-HT with a lower maximum effect, lisuride strongly antagonized the 5-CT-induced hypotensive responses thus suggesting a partial agonist effect. The rank order of hypotensive agonist potency was 5-CT > > 5-HT > or = 5-methoxytryptamine > or = lisuride > > sumatriptan. 3. In experiments with antagonists, i.v. treatment with metergoline (2.48 mumol kg-1), mesulergine (2.76 mumol kg-1), methysergide (2.13 mumol kg-1), lisuride (0.22 mumol kg-1), methiothepin (0.68 mumol kg-1), mianserin (10.6 mumol kg-1), or the atypical antipsychotic drugs, clozapine (11.0 mumol kg-1) or risperidone (78.0 nmol kg-1), produced significant rightward displacements of the dose-response curve for 5-CT in methoxamine-infused pithed animals pretreated with ketanserin (0.18 mumol kg-1, i.v.); lisuride, methiothepin and risperidone behaved as non-competitive antagonists as they elicited a significant reduction of the maximum effect to 5-CT. In contrast, blockade of 5-HT1, 5-HT3 and 5-HT4 receptors with i.v. propranolol (3.38 mumol kg-1), MDL-72222 (1.59 mumol kg-1) and GR125487 (1.91 mumol kg-1), respectively, did not alter 5-CT-induced hypotensive responses; ketanserin (0.18 mumol kg-1, i.v.) failed to modify the dose-response curve for 5-CT in saline-pretreated animals. Lastly, inhibition of the prostaglandin-forming cyclo-oxygenase and nitric oxide synthase with indomethacin (14 mumol kg-1, i.v.) and NG-nitro-L-arginine methyl ester (L-NAME, 120 mumol kg-1, i.v.), respectively, had no significant effects on 5-CT-induced hypotensive effects. 4. Taken together, the present pharmacological data suggest that the long-lasting vasodepressor action of 5-HT in the rat involves activation of receptors closely similar to the cloned 5-ht7 subtype. Since no evidence for an indirect mechanism could be obtained, these receptors may be primarily located in the vascular smooth muscle of the systemic resistance vessels. These findings represent further evidence favouring the functional role of the 5-ht7 receptor.
Blind near-MAP selection diversity with multi-user detection for multi-user OFDM (2004)

In this paper, a receiver algorithm for OFDM with receiver diversity is proposed. The proposed receiver uses a new multi-user generalization of the maximum a posteriori probability (MAP) selection diversity combining followed by successive interference cancellation with least-square projection for multi-user detection. Simulation results show that the proposed approach achieves near-maximal-ratio-combining performance with much lower complexity.
Studies on Tetanus Toxin and Toxid. II. Isolation and Characterization of the Tetanus Toxin and Toxoid (1968)

Crude tetanus toxin and toxoid were prepared by methanol precipitation. The toxin was purified by a combination of TEAE·cellulose and Sephadex G·200 chromatography at pH values less than 6· o. The toxoid was purified by DEAE· cellulose at approximately neutral pH values. The nature and amount of amino acids of the culture medium which had condensed with the tetanus toxoid proteins during detoxification with formaldehyde was determined.
On noise in time-delay integration CMOS image sensors (2016)

Time delay integration sensors are of increasing interest in CMOS processes owing to their low cost, power and ability to integrate with other circuit readout blocks. This paper presents an analysis of the noise contributors in current day CMOS Time-Delay-Integration image sensors with various readout architectures. An analysis of charge versus voltage domain readout modes is presented, followed by a noise classiﬁcation of the existing Analog Accumulator Readout (AAR) and Digital Accumulator Readout (DAR) schemes for TDI imaging. The analysis and classiﬁcation of existing readout schemes include, pipelined charge transfer, buﬀered direct injection, voltage as well as current-mode analog accumulators and all-digital accumulator techniques. Time-Delay-Integration imaging modes in CMOS processes typically use an N-number of readout steps, equivalent to the number of TDI pixel stages. In CMOS TDI sensors, where voltage domain readout is used, the requirements over speed and noise of the ADC readout chain are increased due to accumulation of the dominant voltage readout and ADC noise with every stage N. Until this day, the latter is the primary reason for a leap-back of CMOS TDI sensors as compared to their CCD counterparts. Moreover, most commercial CMOS TDI implementations are still based on a charge-domain readout, mimicking a CCD-like operation mode. Thus, having a good understanding of each noise contributor in the signal chain, as well as its magnitude in diﬀerent readout architectures, is vital for the design of future generation low-noise CMOS TDI image sensors based on a voltage domain readout. This paper gives a quantitative classiﬁcation of all major noise sources for all popular implementations in the literature.
Myelofibrosis With Myeloid Metaplasia: Diagnostic Definition and Prognostic Classification for Clinical Studies and Treatment Guidelines (1999)

"Consensus" methodology offers a definition of MMM useful for conducting and reporting clinical studies. A detailed knowledge of prognostic factors can help to delineate guidelines for addressing patients with allogeneic SCT.