gebhart/patrepeval huggingface dataset:
Silicone Mastitis in “Topless” Waitresses and Some Other Varieties of Foreign-body Mastitis (1968)

Three cases of disfiguring prosthetogenic mastitis are reported.In two of the cases repeated injections of silicone fluid were followed by extensive bilateral granulomatous mastitis. The axillary lymph nodes were enlarged in both cases: in one of them a node was examined histologically and showed a remarkable proliferation of vacuolated histiocytes in the sinuses and medulla. Both patients had worked in "topless restaurants" and had been obliged to seek artificial means to maintain the excessively large bust that was necessary in that environment.The third patient's mastitis followed implantation of polyethylene prostheses designed to be varied in bulk by injection or withdrawal of saline. A foreign-body reaction developed round the prostheses. In addition, a sinus developed in a needle track on one side; this was accompanied by a local fungal and bacterial infection (Rhizopus species and Pseudomonas pyocyanea respectively).The indications for introducing foreign materials into the breasts to augment their size have to be weighed against the potential dangers that such procedures bring. The biological effects of injected silicones, particularly their long-term effects, are very imperfectly known. Statements implying that these compounds are harmless when injected are not correct. Among the hazards are (a) local sclerosing granulomatous reactions with permanent scarring, (b) histiocytosis secondary to carriage of silicones from their site of inoculation to regional lymph nodes and possibly to other parts of the lymphoreticular system, and, perhaps, (c) carcinogenic activity.
Comparative Activity of Tobramycin, Amikacin, and Gentamicin Alone and with Carbenicillin Against <i>Pseudomonas aeruginosa</i> (1974)

The effect of gentamicin against 130 clinical isolates of Pseudomonas aeruginosa was compared with that of two investigational aminoglycoside antibiotics, tobramycin and amikacin. Minimal inhibitory concentration data indicated that, on a weight basis, tobramycin was two to four times as active as gentamicin against most isolates. However, 14 of 18 organisms highly resistant to gentamicin (>/=80 mug/ml) were also highly resistant to tobramycin. Amikacin was the least active aminoglycoside on a weight basis, but none of the isolates were highly resistant to this antibiotic. When therapeutically achievable concentrations were used, adding carbenicillin to gentamicin or to tobramycin enhanced inhibitory activity against those isolates susceptible (</=5 mug/ml) or moderately resistant (10 to 40 mug/ml) to the aminoglycoside. Such synergy was seldom demonstrated for isolates highly resistant to gentamicin or tobramycin. The combination of carbenicillin and amikacin enhanced inhibition against all but two of the isolates. Both tobramycin and amikacin offer in vitro advantages over gentamicin against P. aeruginosa.
Dual Inhibition of Activin/Nodal/TGF‐<i>β</i> and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells (2015)

Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent treatment option in this regard. Preclinical studies demonstrate that untreated stem cells, unlike stem cells activated to differentiate into neuronal lineage, do not survive in the neuronal tissues. Conventional methods of inducing neuronal differentiation of stem cells are complex and expensive. We therefore sought to determine if a simple, one-step, and cost effective method, previously reported to induce neuronal differentiation of embryonic stem cells and induced-pluripotent stem cells, can be applied to adult stem cells. Indeed, dual inhibition of activin/nodal/TGF-β and BMP pathways using SB431542 and dorsomorphin, respectively, induced neuronal differentiation of human adipose derived stem cells (hADSCs) as evidenced by formation of neurite extensions, protein expression of neuron-specific gamma enolase, and mRNA expression of neuron-specific transcription factors Sox1 and Pax6 and matured neuronal marker NF200. This process correlated with enhanced phosphorylation of p38, Erk1/2, PI3K, and Akt1/3. Additionally, in vitro subcutaneous implants of SB431542 and dorsomorphin treated hADSCs displayed significantly higher expression of active-axonal-growth-specific marker GAP43. Our data offers novel insights into cell-based therapies for the nervous system repair.
Superconductors in instrumentation (1964)

During the last two decades the unique and unusual properties of superconductors have begun to be extensively exploited. Some of the applications, both suggested and actual, are reviewed in this paper. There are several which have lead to `instruments' in the broadest sense. The superconducting bolometer depending on the steep resistance-temperature characteristic in the transition is an example. Superconducting galvanometers of very high sensitivity have also been developed. The destruction of superconductivity by a magnetic field leads to a variety of switches which have zero resistance when `closed' and finite resistance when `open'. The most well known is probably the cryotron which has received a great deal of attention with a view to computer applications. Switches of this type provide the basis of laboratory modulators and amplifiers which are capable of detecting extremely small voltages.
Economics of Single and Bundle Conductors for Extra-High-Voltage Transmission (1960)

1. A method has been developed whereby the optimum configuration and conductor area may be determined for a given EHV transmission line, taking into account all the parameters which have economic significance. 2. This method is general, and applicable to a wide range of system configurations, transmission distances, voltages, and loadings per circuit. Economic evalution factors may be varied to agree with available cost data, and the judgment and policies of the utility management. 3. This method is embodied into a digital computer program for the IBM705 computer, providing rapid computation of any case to be investigated. 4. Fifty-eight different cases were investigated in this study, to determine the effect of varying the system parameters and the economic evaluation factors over a wide range of values which are of practical interest for the United States and Canada. 5. Annual cost differentials between the minimum cost points for the various configurations are considerable and correspond to several per cent of the annual charges on the line investment. 6. The optimum configuration depends upon the particular values of the system parameters and economic evaluation factors. Therefore it is difficult to draw over-all conclusions, valid for all cases. Rather, each specific case will have to be investigated separately according to the method described in this paper. 7. In general, as the load per circuit increases, relative to surge impedance loading, the number of conductors per phase corresponding to the optimum configuration also increases. 8.
Terror in the Name of Human Rights (2006)

The dominant political language of today seems to involve the notion that the 'terrorists' and 'outlaw states' threaten peace, human rights, dignity and freedom, and that in defence of these values 'we' are justified in going to war. This article draws attention to the highly problematic nature of this form of moral thinking about war. The article develops a jurisprudence of war and violence built upon the philosophy of Kant and Hegel. Contemporary acts of war and terror are positioned within the notion of 'war's moral problem' and are reconceived as a problem and a challenge of (mis)recognition.
Reconfigurable logic for array processing (2002)

The architecture of the MIX system is described. It was designed to investigate some of the factors involved in applying reconfigurable and/or fixed logic in a typical engineering algorithm. A matrix-vector multiplier of 32 bit floating point numbers, is used as a vehicle for the investigation. The results indicate that fixed logic is more suited for floating point units and memories while reconfigurable logic is useful for implementing control logic providing significant flexibility. It is also found that the additional delay in reconfigurable logic can very effectively overlap with the operating time of the fixed logic subsystems. The advantage of reconfigurability of the control is therefore combined with the high bandwidth properties of the fixed logic.
Parallel structured duplicate detection (2007)

We describe a novel approach to parallelizing graph search using structured duplicate detection. Structured duplicate detection was originally developed as an approach to externalmemory graph search that reduces the number of expensive disk I/O operations needed to check stored nodes for duplicates, by using an abstraction of the search graph to localize memory references. In this paper, we show that this approach can also be used to reduce the number of slow synchronization operations needed in parallel graph search. In addition, we describe several techniques for integrating parallel and external-memory graph search in an efficient way. We demonstrate the effectiveness of these techniques in a graphsearch algorithm for domain-independent STRIPS planning.
Regeneration of Aspergillus nidulans Protoplasts (1971)

SUMMARY: The process of regeneration of mycelial protoplasts from Aspergillus nidulans wild-type and strain P76 has been investigated. In liquid media two patterns of regeneration were observed. In the first, the protoplasts produced chains of yeastlike cells and eventually the terminal cell produced a hypha. In the second wall ‘shells’ were formed into which the cytoplasm migrated. It is suggested that the mechanism of regeneration reflects the site of origin of the protoplast from the parent hypha.
An investigation on fire hazard and smoke toxicity of epoxy FRP composites (2017)

Purpose The purpose of this study is assessment of fire and smoke hazards of some fiber reinforced polymers (FRP). The use of FRP strengthening strips has been found rapid growth in construction industry of Iran and many other countries. However, the fire and smoke hazards of these materials in both construction and use phases need to be determined and the appropriated measures against fire should be taken. Design/methodology/approach The fire hazards of two types of fibre-reinforced epoxy composites (graphite fibre-reinforced polymer and carbon fibre-reinforced polymer) were investigated in bench-scale using cone calorimeter test method. Time to ignition, heat release rate, total heat release, smoke release and carbon monoxide production were measured and analysed. Time to flashover of an assumed room lined with the tested FRP was analysed with Conetools software. Smoke production and toxicity of the considered composites were also analysed and discussed, using the fractional effective dose parameter. Findings The results showed that the tested FRP products had a high fire hazard and a potential high contribution to fire growth. The tests also proved that the used epoxy resin had a low glass transition temperature, around 50°C; therefore, the mechanical strength of the product could be drastically reduced at first stages of a probable fire incident. This also showed that a regular thermal barrier, typically used for protection of plastic foams against fire, could not be sufficient for the protection of strengthening FRP composites. Originality/value This research was carried out for the first time for the materials used in construction industry of Iran. The results and achievements were very useful for safe use and development of proper details of application of the system.
Epithelioid angiosarcoma of the scapula. (2011)

Epithelioid angiosarcoma is a rare variation of an angiosarcoma and its localization in the bone is exceptionally infrequent. This report presents the case of a 48-year-old male with an epithelioid angiosarcoma of the scapula. In CT and MRI scans an inhomogeneous tumour with osseous destructions, lytic areas, central necrosis and marginal hyperperfusion was observed. The bordering skeletal muscles were already infiltrated. The tumour was treated initially with neoadjuvant chemotherapy, followed by dose escalation, peripheral blood stem cell transplantation and resection of the lesion. Despite advanced local tumour stage at initial presentation, the patient is in complete remission.
Handbook of Pulp and Paper Technology (1975)

Handbook of pulp and paper Technology , Handbook of pulp and paper Technology , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Pharmacological analysis of a new anorexic substance: 5-hydroxy-5(4'-chlorophenyl)-2, 3-dihydro-5H-imidazo-(2, 1-a) isoindole (Mazindol). (1975)

5-Hydroxy-5-(4'-chlorophenyl-2, 3-dihydro-5H-imidazo (2, 1-a)isoindole (mazindol), a novel tricyclic compound, has been shown to suppress food consumption in rats at doses causing weak central stimulation and little effects on blood pressure or heart rate. The substance produces dose-related decreases in the consumption of orange juice in cebus monkeys trained on an operant behavior schedule. The compound did not alter cardiac or pulmonary hemodynamics in the anesthetized dog but provided potentiation of norepinephrine pressor responses. Mazindol also demonstrated potent but incomplete antagonism of reserpine-induced hypothermia in mice, antagonism of tetrabenazine catalepsy in rats, and suppression of mouse-killing behavior of rats. Suppression of mouse-killing was reduced by lesions placed in the septal area of the brain. Brain monoamine oxidase or catechol-o-methyl-transferase activities were not altered, although preliminary experiments showed that mazindol reduced uptake of norepinephrine in brain tissue.
Technique for broadband correlated interference rejection in microphone arrays (1998)

A new technique for broadband minimum variance beam-forming is presented that overcomes the signal cancellation problem of conventional adaptive beamformers in the presence of correlated interference. Specifically, frequency-invariant beam-forming is used to perform frequency domain averaging, thereby reducing the correlation between the desired signal and the interference. Such a technique is useful for hands-free speech acquisition using a microphone array, since correlated interference will be present due to room reflections.
Droplet Microfluidics for the Production of Microparticles and Nanoparticles (2017)

Droplet microfluidics technology is recently a highly interesting platform in material fabrication. Droplets can precisely monitor and control entire material fabrication processes and are superior to conventional bulk techniques. Droplet production is controlled by regulating the channel geometry and flow rates of each fluid. The micro-scale size of droplets results in rapid heat and mass-transfer rates. When used as templates, droplets can be used to develop reproducible and scalable microparticles with tailored sizes, shapes and morphologies, which are difficult to obtain using traditional bulk methods. This technology can revolutionize material processing and application platforms. Generally, microparticle preparation methods involve three steps: (1) the formation of micro-droplets using a microfluidics generator; (2) shaping the droplets in micro-channels; and (3) solidifying the droplets to form microparticles. This review discusses the production of microparticles produced by droplet microfluidics according to their morphological categories, which generally determine their physicochemical properties and applications.
Determination of Orientation in Thermotropic Liquid Crystalline Polymer Films by Spectrographic Measurement of the Birefringence (1996)

The degree of orientation in thermotropic liquid crystalline polymer films has been determined as a function of the draw ratio using a specially developed spectrographic birefringence technique, diffuse reflectance infrared spectroscopy (DRIFT), and wide-angle X-ray scattering (WAXS). Quantitative measurements of the average birefringence were obtained despite the huge turbidity of the samples. The order parameter calculated from the birefringence was found to depend on the draw ratio according to the Kuhn and Grün equation for pseudo-affine deformation. The infrared dichroism was measured as a function of film thickness by layer removal. The thickness-averaged orientation calculated from the DRIFT measurements also indicated affine deformation of the films. The orientation derived from WAXS appeared to be clearly overaffine. The difference between the results from WAXS and the results from the other two techniques is attributed to preferential orientation of the crystalline fraction due to flow-induced crystallization in the films which is detected only by WAXS.
Purification of Deoxyhypusine Synthase from Neurospora crassa to Homogeneity by Substrate Elution Affinity Chromatography (1995)

Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyzes the formation of deoxyhypusine residue on the eIF-5A precursor by using spermidine as the substrate. Deoxyhypusine synthase bound tightly to 1,12-diaminododecane-agarose and could be eluted selectively by spermidine. This finding enabled us to develop a simple two-column procedure to purify deoxyhypusine synthase from Neurospora crassa to apparent homogeneity. The purified enzyme had a specific activity of 130,000 units/mg of protein, representing a 64,000-fold purification from cell extracts. Size exclusion chromatography indicated that the native enzyme had a molecular mass of 180 kDa. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the pure enzyme showed a single band at the 40-kDa position, suggesting that Neurospora deoxyhypusine synthase is a homotetramer. Deoxyhypusine synthase appeared to be hydrophobic and required non-ionic detergent such as Tween 20 to stabilize the activity. Treatment of the enzyme with sulfhydryl reagents resulted in a complete loss of activity. Inclusion of NAD+ reduced the inactivation rate by manyfold, indicating the presence of -SH groups at or near the active site. Partial amino acid sequences of four peptide fragments that cover about one quarter of the enzyme were obtained for cDNA and genomic cloning work.
Circumstantial Evidence That An Abnormality of Calcium Transport May Be Important in Essential Hypertension (1981)

Conference Abstract| March 01 1981 Circumstantial Evidence That An Abnormality of Calcium Transport May Be Important in Essential Hypertension G. A. MacGregor; G. A. MacGregor 1Department of Medicine, Charing Cross Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar N. D. Markandu; N. D. Markandu 1Department of Medicine, Charing Cross Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar J. Bayliss; J. Bayliss 1Department of Medicine, Charing Cross Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar M. Brown; M. Brown *Department of Clinical Pharmacology, Royal Postgraduate Medical School, London Search for other works by this author on: This Site PubMed Google Scholar J. E. Roulston J. E. Roulston 1Department of Medicine, Charing Cross Hospital Medical School, London Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1981) 60 (3): 6P–7P. https://doi.org/10.1042/cs060006Pc Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation G. A. MacGregor, N. D. Markandu, J. Bayliss, M. Brown, J. E. Roulston; Circumstantial Evidence That An Abnormality of Calcium Transport May Be Important in Essential Hypertension. Clin Sci (Lond) 1 March 1981; 60 (3): 6P–7P. doi: https://doi.org/10.1042/cs060006Pc Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1981 The Biochemical Society and the Medical Research Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
Eukaryotic ribonucleases HI and HII generate characteristic hydrolytic patterns on DNA-RNA hybrids: further evidence that mitochondrial RNase H is an RNase HII (2000)

RNase H activities from HeLa cells (either of cytoplasmic or mitochondrial origin), and from mitochondria of beef heart and Xenopus ovaries, have been tested with RNA-DNA substrates of defined length (20 bp) and sequence. Substrates were either blunt-ended, or presented DNA or RNA overhangs. The hydrolysis profiles obtained at early times of the digestion showed a good correlation between the class of RNase H, either type I or II assigned according to biochemical parameters, whatever the organism. Consequently, the pattern of primary cuts can be considered as a signature of the predominant RNase H activity. For a given sequence, hydrolysis profiles obtained are similar, if not identical, for either blunt-ended substrates or those presenting overhangs. However, profiles showed variations depending on the sequence used. Of the three sequences tested, one appears very discriminatory, class I RNases H generating a unique primary cut 3 nt from the 3' end of the RNA strand, whereas class II RNases H generated two simultaneous primary cuts at 6 and at 8 nt from the 5' end of the RNA strand. Hydrolysis profiles further confirm the assignation of the mitochondrial RNase H activity from HeLa cells, beef heart and Xenopus oocytes to the class II.
Effects of adult body size on fecundity and the pre‐gravid rate of Anopheles gambiae females in Tanzania (1993)

The influence of adult body size on the pre-gravid state and fecundity was studied in Anopheles gambiae Giles females hand-caught inside houses and virgin females collected as pupae in Tanzania. Blood-fed mosquitoes were kept for 2-3 days before dissection and examination for insemination and ovarian condition. Those females which did not develop eggs were classified as pre-gravid. The number of mature eggs in those mosquitoes which became gravid was counted. Virgin females were fed and kept for egg maturation in the laboratory. Wing-length of females was measured as an index of mosquito size. The overall pre-gravid rate in the resting An.gambiae population was found to be 21% and, of these, 66% had been inseminated. In the virgin females the pre-gravid rate was 92.6%. The mean wing-length of wild females which became gravid was significantly larger than those which remained pre-gravid. There was a positive correlation between fecundity and wing-length. Smaller females tended to require two or three bloodmeals to facilitate completion of the first gonotrophic cycle. The critical size permitting oviposition from the first blood-meal was a wing-length of 3 mm.