gebhart/patrepeval huggingface dataset:
Bombesin and Ceruletide‐induced Grooming and Inhibition of Ingestion in the Rata (1988)

Peptides of diverse structure stimulate grooming in rodents and other mammals. Peptide-induced grooming may be observed in several motivational contexts, with or without strong alternative response tendencies. Bombesin-like peptides elicit grooming route dependently in the rat and hamster, independently of, or concomitantly with, changes in ingestive behaviors or resting. The pattern of body surfaces groomed after i.c.v. BBS is in proportion to the representation of body surfaces in somatosensory but not motor cortex of rat. A bombesin-like peptide may be a neurotransmitter in somatosensory afferent processing, and grooming after i.c.v. BBS may reflect a response to alteration of cutaneous sensation. Bombesin is a putative satiety signal in the control of feeding and ethanol intake, but the satiation effects of systemic BBS can be dissociated from the grooming effect of central BBS. Thus, bombesin may perform independent and site-specific functions in the control of behavior. Grooming produced by BBS is not affected by naloxone, involves a different proportion of motor acts than is observed in normal or ACTH-induced grooming, and no cross-tolerance has been reported between ACTH and BBS in the rat. These properties of bombesin-induced grooming indicate multiple, separable mechanisms of peptide-induced grooming and scratching. Cholecystokinin-like peptide-induced grooming is observed after central injection in the rat and is unaccompanied by changes in feeding or resting. The well-documented satiety action of systemic CCK-like peptides is not accompanied by excessive grooming, so multiple, site-specific behavioral roles are also indicated for CCK-like peptides in control of behavior. CCK-8 exhibits short-term cross-tolerance with ACTH in elicitation of grooming, and central CCK-8 is co-localized with CRF and stimulates ACTH and corticosterone release in the rat. Thus, CCK-8 may induce grooming by increasing CRF or ACTH activity. These properties of CCK-like peptide-induced grooming indicate convergent neuroendocrine mechanisms that may explain some, but not all, peptide-induced grooming syndromes. Further characterization of the qualitative topographic, neuropharmacological, and neuroanatomical differences and species specificities of peptide-induced excessive grooming should provide a basis for understanding how brains coordinate grooming. Knowledge of the processes of neuropeptide control of grooming may provide potential peptide-based controls of grooming-related clinical disorders such as pruritus and allergic reactions.(ABSTRACT TRUNCATED AT 400 WORDS)
Experimental Study of Gusseted Connections (1990)

Gusset plate connections are common in lateral bracing systems in steel construction. Recent analytical studies have demonstrated that the gusset plate produces a rigid beam-to-column connection, even if the beam flanges are not connected to the column. The importance of this rigid beam to-column connection is that the gusset plate carries a significant load from "frame action" in addition to that from the diagonal bracing member. The influence of framing members on gusset plate behavior has not yet been studied experimentally and the effect of the stresses produced by frame action on the gusset plate capacity is not known. In addition, tests to date have all used configurations in which the centroidal axes of the members framing into the connection have all intersected at a single point. The loads introduced into a gusseted connection when the centroidal axes of the framing members do not intersect at a point have not been experimentally determined. Finally, the column in a lateral bracing system may be oriented so that the gusset is connected either to the flange or to the web. Unless the web is stiffened, a connection to the column web is more flexible than one in which the gusset is connected to the flange. No experimental work to date has addressed the difference in performance between these two types of column connection and no data is available to indicate whether stiffening of the web is required.
Modulation of the oscillatory mechanics of lung tissue and the oxidative stress response induced by arginase inhibition in a chronic allergic inflammation model (2013)

In this experimental model, increased arginase content and iNOS-positive cells were associated with the constriction of distal lung parenchyma. This functional alteration may be due to a high expression of 8-isoprostane, which had a procontractile effect. The mechanism involved in this response is likely related to the modulation of NF-kB expression, which contributed to the activation of the arginase and iNOS pathways. The association of both inhibitors potentiated the reduction of 8-isoprostane expression in this animal model.
Chańarcillo (Puna de Atacama, Chile) jako geologiczne stanowisko dokumentacyjne i zabytek górnictwa związany z Domeyką (2002)

CHAŃARCILLO (PUNA DE ATACAMA, CHILE): PROPOSED GEOSITE AND MINING MONUMENT RELATED TO I. DOMEYKO. 

Summary
 
Brief history of Chilean mining industry and an important silver mine of mid-19th century, Chanarcillo, is described. Excerpts from books and letters by I. Domeyko document the mining and geological activities of those pioneering years. At the same time they provide insight into his outstanding personality, intentions, broad scope of interests and activities, as well as didactic and literary talents. An idea of turning the abandoned Chanarcillo mine into a geosite of general interest and training area for students of geology and mining is developed in cooperating universities of Chile and Poland, which cultivate Domeyko’s traditions.
Simultaneous estimation of rosuvastatin calcium and hydrochlorthiazide from bulk and commercial products using a validated reverse phase high performance liquid chromatographic technique (2012)

Aim: An approach for Simultaneous estimation of rosuvastatin calcium and hydrochlorthiazide from bulk and commercial products using a validated reverse phase high performance liquid chromatographic technique. Materials and Methods: The separation of both the drugs was achieved on ACE C 18 AR (AR - Aromatic) column (250 × 4.6 mm, 5 μm) column using a mobile phase of sodium perchlorate buffer solution (at pH 3.0) : a0 cetonitrile (60:40 v/v). The flow rate was 1 ml/min and detection was done at 280 nm. Results: The retention time for Hydrochlorothiazide was 3.9 min and for Rosuvastatin calcium was 10.3 min. Rosuvastatin calcium and Hydrochlorothiazide showed a linear response in the concentration range of 5-30 μg/ml and 6.25-37.5 μg/ml respectively. The correlation co-efficients for Rosuvastatin calcium and Hydrochlorothiazide were 0.9998 and 0.9999 respectively. The percentage recoveries obtained for Rosuvastatin calcium and Hydrochlorothiazide range from 99.3% to 100.4% and 99.2% to 100.4% respectively. The results of analysis have been validated as per the International conference on Harmonisation (ICH) guidelines. Conclusion: Validation results indicated that the method shows satisfactory linearity, accuracy, precision, and ruggedness. The extremely low flow rate, simple mobile phase composition makes this method cost-effective, rapid, and non-tedious and can also be successfully employed for simultaneous estimation of both drugs in commercial products.
Wetting Patterns and Preferential Flow in Soils (2013)

Knowledge of the movement of water and solutes through the vadose zone of soils is essential for reliable predictions of pollution risks to groundwater. So far, most models simulating water and solute transport through the unsaturated zone have assumed homogeneous infiltration and a subsequent downward movement of the wetting front parallel to the soil surface. This type of stable flow, however, is uncommon in field soils. Deviations are caused by a variety of mechanisms. Firstly, preferential flow of water and solutes may occur in well-structured clay and/or peat soils owing to the presence of shrinkage cracks. Secondly, preferential flow may also occur in non-structured sandy soils, owing to the development of unstable wetting fronts. Fingers or preferential flow paths occur if (1) the hydraulic conductivity increases with depth, as is encoutered in soils with a fine-textured layer covering a coarse-textured layer; and (2) the soil is water repellent. Irregular wetting patterns and preferential flow paths have been established in the Netherlands in wettable dune sands and in water repellent sand, clay, and peat soils.
The detection of coronary artery disease with radionuclide techniques: a comparison of rest-exercise thallium imaging and ejection fraction response. (1980)

Fifty-two patients with suspected coronary artery disease underwent coronary angiography, thallium-201 myocardial imaging, and ECG-gated blood pool ventriculography at rest and at maximal exercise. In 11 patients without coronary artery disease, all thallium images were normal. The resting ejection fraction (EF) was normal in all 11 patients and increased during exercise in six, was unchanged in three, and decreased in two. Of the 41 patients with coronary artery disease, the thallium image was normal at rest and at exercise in six (15%), whereas the exercise EF was abnormal in these six. A new (18 patients) or enlarged (11 patients) defect appeared on the thallium image in 29 of 41 patients (71%) with coronary disease. Six of 41 patients (15%) had an abnormal rest thallium image that was unchanged with exercise. An abnormal rest and/or exercise image defect identified 35 of 41 patients (85%) with coronary artery disease. The resting EF was normal in 26 of the 41 patients (63%) and in 24 patients demonstrated an abnormal response to exercise. Fifteen patients (37%) had an abnormal resting EF, and 14 of these 15 demonstrated persistent abnormalities. Thus, an abnormal exercise EF response identified 38 of 41 (93%) patients with coronary disease. The specificity of the thallium image was 100% and for the exercise EF determination, 54% (p < 0.02). We conclude that an abnormal exercise EF response and the rest-exercise thallium image have similar sensitivities for detecting coronary disease; however, an abnormal exercise ejection fraction was significantly more sen- sitive than was a new thallium abnormality alone (93% vs 71%). Combined, the two studies detected all patients with coronary disease.
Thermoreversible (Ionic-Liquid-Based) Aqueous Biphasic Systems (2016)

The ability to induce reversible phase transitions between homogeneous solutions and biphasic liquid-liquid systems, at pre-defined and suitable operating temperatures, is of crucial relevance in the design of separation processes. Ionic-liquid-based aqueous biphasic systems (IL-based ABS) have demonstrated superior performance as alternative extraction platforms, and their thermoreversible behaviour is here disclosed by the use of protic ILs. The applicability of the temperature-induced phase switching is further demonstrated with the complete extraction of two value-added proteins, achieved in a single-step. It is shown that these temperature-induced mono(bi)phasic systems are significantly more versatile than classical liquid-liquid systems which are constrained by their critical temperatures. IL-based ABS allow to work in a wide range of temperatures and compositions which can be tailored to fit the requirements of a given separation process.
Problemstellung: Die Ermittlung rechtlicher und ökonomischer Komponenten als Entscheidungskriterium zur Durchsetzung ziviler Rechtsansprüche — ein betriebswirtschaftliches Problem der Praxis (1992)

Eine in der juristischen Literatur getroffene Feststellung lautet: Rechtliche Ordnung ist kein Bestandteil der außermenschlichen Natur, sondern eine „Ordnung unter Menschen, für Menschen und durch Menschen“.1) Die Rechtsordnung liegt folglich in der Gesellschaft begründet, die, wie die Realität zeigt, keineswegs konfliktfrei ist.
Determination of Trace Amounts of Copper (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Trace Amounts of CopperL. G. Borchardt and J. P. ButlerCite this: Anal. Chem. 1957, 29, 3, 414–419Publication Date (Print):March 1, 1957Publication History Published online1 May 2002Published inissue 1 March 1957https://pubs.acs.org/doi/10.1021/ac60123a026https://doi.org/10.1021/ac60123a026research-articleACS PublicationsRequest reuse permissionsArticle Views473Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The NEPTUNE Canada Communications Network (2007)

One of the objectives of the NEPTUNE Canada Regional Cable Observatory (RCO) is to provide a communications platform for undersea applications linked to the global Internet. Supported applications include sensor polling, command and control, file transfer, data streaming and video streaming. Ideally, the observatory infrastructure will also be forward compatible with as yet unknown applications. Achieving these goals requires a comprehensive communications architecture stretching from the most remote instruments to the Internet. The key components of this architecture are the observatory backbone and nodes, extension cables, junction boxes, serial device servers, shore based routers, and a backhaul link connecting the shore station to the Internet. The observatory backbone and nodes are integrated and delivered under a single supply contract. Junction boxes, extension cables, instrument pods and the science instruments and sensors are each procured separately and must be integrated and tested prior to deployment. The IEEE 802.1 and 802.3 (Ethernet) series of standards are relied upon to ensure compatibility between network elements. Link Aggregation Control Protocol (802.3ad) and Virtual Local Area Networking (802.1Q) provide essential functionality for observatory operation. The NEPTUNE Canada communications architecture immediately supports IPv4 and key underwater components also support IPv6. The NEPTUNE Canada design allows expansion through the addition of nodes and junction boxes, upgrade from 2.5 Gb/s to 10 Gb/s optical channels, and extension of the backbone cable. The network design selected by NEPTUNE Canada has many benefits, but is not ideal in all respects. Nonetheless, an analysis of the design risks and tradeoffs shows that most of these are well managed by the selected design. Future generations of RCOs can extend the NEPTUNE Canada architecture by increasing the number of optical fibers, increasing the optical channel data rate, or introducing node-to-node optical channels.
Face Recognition Based on Discriminant Sparsity Preserving Embedding (2014)

Motivated by the recent rapid development of sparse representation(SR) on feature extraction and dimensionality reduction of high-dimensional data such as face images, an improved version of sparsity preserving projection(SPP), named discriminant sparsity preserving embedding(DSPE), is proposed in this paper. Through solving a least square problem, the sparse weight of SPP is updated and the discriminant sparse weight which actually reflects the discriminant information is obtained. Then the low-dimensional feature subspace of the original high-dimensional data is evaluated by best preserving such sparse weight relationship. DSPE is a linear supervised learning method which can deal with high-dimensional data efectively by introducing discriminant information. The efectiveness of the proposed method is verified on four popular face databases(ORL, Yale, Extended Yale B, and CMU PIE) with promising results.
Line-Start Permanent-Magnet Motors: Significant Improvements in Starting Torque, Synchronization, and Steady-State Performance (2010)

We present a new scheme to improve the starting torque and synchronization capability of line-start permanent-magnet motors based on pole changing winding. Pole changing at start-up neutralizes the magnetic influence of permanent magnets and, therefore, leads to the elimination of braking and pulsating torques, and enhances the starting torque. Our scheme also solves the synchronization problem. We used finite-element analysis to validate the scheme. The simulation results show that the method leads to a high starting torque, good synchronization, and excellent steady-state performance.
Small peptides bound to polysomal RNA inhibit gene expression in cell-free systems, replication of stimulated lymphocytes and DNA repair in isolated chromatin. (1985)

Polysomal poly(A)+-RNA prepared from isolated calf liver polysomes by deproteinization and affinity chromatography on oligo(dT)-Sepharose at pH 6 contains low molecular weight peptides (between 600-1500 daltons) bound noncovalently. These peptides were extracted from the poly(A)+-RNA-peptides complex by precipitation of the nucleic acids with 80% (v/v) ethanol at alkaline pH (9.5) and purified on Sephadex G-25 and G-15 columns. Further fractionation was performed by silica gel chromatography and high performance liquid chromatography (h.p.l.c.). The amino acid composition of the isolated peptidic fraction was compared with similar peptides obtained from rat liver, rabbit reticulocyte and calf thymus polysomes. Effluent (ribosomal) RNA contains only negligible amount of peptides. Isolated polysomal RNA peptides were named "deprimerones" (from Latin "deprimere"), since they have a general depressing effect on gene expression in vitro (Hillar & Przyjemski, 1979). Isolated deprimerones not only inhibit DNA transcription, RNA translation in reconstituted cell-free systems, but also DNA replication by DNA polymerase beta with single- and double-stranded DNA template and synthetic deoxyribonucleotide polymers. The inhibitory effect on replication was correlated with the inhibition of [3H]-deoxyribonucleotide incorporation in isolated chromatin and in stimulated lymphocyte cell cultures. The isolated deprimerones are characterized by similar amino acid compositions in various species.
Electrochemical properties of La0.8Sr0.2FeO3-δ based composite cathode for intermediate temperature SOFC (2006)

La0.8 Sr0.2FeO3-δ is a new kind of cathode material for intermediate SOFC, but its electrochemical activity is relative poor for the lanthanum gallate based solid oxide fuel cell. In this paper, a novel composite cathode of La0.8Sr0.2FeO3-δ/La0.9Sr0.1 Ga0.8Mg0.2O3-δ was prepared on the LSGM electrolyte substrate by screen-printing method. The results of cathodic polarization measurements show that the overpotential decreases significantly when the composite cathode is used instead of the La0.8Sr0.2 FeO3-δ single layer cathode. The cathodic overpotential of the composite La0.8Sr0.2FeO3-δ/La0.9Sr0.1Ga0.8Mg0.2O3-δ cathode is 150 mV at the current density of 0.2 A·cm−2 at 800 °C, while the cathodic overpotential of the La0.8Sr0.2 FeO3-δ single layer cathode is higher than 260 mV at the same condition. The electrochemical impedance spectroscopy was employed to investigate the polarization resistance of the cathode. The polarization resistance of the composite cathode is 1.20 ω·cm2 in open circuit condition, while the value of the single La0.8 Sr0.2FeO3-δ cathode is 1.235 ω·cm2.
Comparison of brain SPECT using 99mTc-bicisate (L,L-ECD) and [123I]IMP in cortical and subcortical strokes. (1994)

Single photon emission computed tomography (SPECT) using 99mTc-bicisate and N-isopropyl-p-[123I]iodoamphetamine ([123I]IMP) was compared in 25 patients suffering cerebral ischemia during the subacute phase (7-14 days) of stroke. Patients were classified as cortical strokes (15) and subcortical strokes (10) according to clinical and CT data. Images were analyzed by five independent blinded observers. Then, using a cross-matching method between normal and abnormal brain areas, we evaluated the sensitivity and specificity for 99mTc-bicisate and [123I]IMP and inter- and intraobserver reproducibility. A semiquantitative analysis was performed to compare abnormal hypoactive areas versus the corresponding contralateral areas for 99mTc-bicisate and [123I]IMP in the two patient groups. There was no significant difference for sensitivity and specificity between 99mTc-bicisate and [123I]IMP. Matching was approximately 90% in the two groups. The kappa-concordance index was satisfactory and slightly better for 99mTc-bicisate (0.485) than for [123I]IMP (0.435). Level of hypoactivity in the abnormal areas was significantly higher for 99mTc-bicisate (p < 0.03, n = 25) than for [123I]IMP, especially for cortical strokes. This comparative study demonstrates that 99mTc-bicisate is a very useful tracer for the detection of focal cerebral ischemia by SPECT during the subacute phase of stroke.
Alginate-Pectin-Poly-L-lysine Particulate as a Potential Controlled Release Formulation (1999)

Drug delivery particulates were prepared using alginate, polylysine and pectin. Theophylline, chlorothiazide and indomethacin were used as the model drugs for in-vitro assessments, and mannitol was the model for assessing paracellular drug absorption across Caco-2 cell monolayers. Alginate and pectin served as the core polymers and polylysine helped to strengthen the particulates. Use of pectin specially helped in forming a more robust particulate that was more resistant in acidic pH and modulated the release profiles of the encapsulated model drugs in the alkaline pH. Alginate and pectin were also found to enhance the paracellular absorption of mannitol across Caco-2 cell monolayers by about three times. The release rate could be described as a first-order or square-root time process depending on the drug load. Use of alginate-polylysine-pectin particulates is expected to combine the advantages of bioadhesion, absorption enhancement, and sustained release. This particulate system may have potential use as a carrier for drugs that are poorly absorbed after oral administration.