gebhart/patrepeval huggingface dataset:
Modulation of erythrocyte-endothelial interactions and the vasocclusive severity of sickling disorders (1981)

The abnormal adherence of sickle erythrocytes to cultured human vascular endothelium varies among patients and correlates with vasocclusive severity within and among the different sickling disorders. For individual patients, the development of an acute vasocclusive event is not accompanied by an increase in the inherent propensity for their erythrocytes to adhere to endothelium. However, the onset of vasocclusion appears to be associated with the appearance of plasma factors, such as fibrinogen, which enhance the adherence of sickle erythrocytes to endothelium. In addition, sickle erythrocytes adhere even more avidly to injured endothelium and under hyperosmolar conditions. Thus, the overall clinical severity of the sickling disorders appears to correlate with the inherent propensity for sickle erythrocytes to adhere to endothelium, and changes in the red cells' environment may help precipitate crises by the sudden facilitation of erythrocyte/endothelial interactions.
X-ray collimator based on a polycapillary lens to form main geometries of diffractometry (2014)

The idea of using the extended focus of a polycapillary lens in the parallel-beam diffraction geometry is verified.
Designed-in maintenance features of the I-70 Mississippi river bridge (2005)

The new 12-lane I-70 cable stayed bridge in St. Louis will be one of the longest and widest cable stayed bridges in the world. Several requirements imposed by the owners to promote long-term durability had major effects on design and detailing features. Among these requirements were a design service life of 150 years, design for future deck replacement, and the use of a two-level seismic design with a high level design for a 2,500-year event with a performance level of Service Immediate. This paper reviews some of the resulting unique features. For the covering abstract see ITRD E126028.
The New Antiepileptic Drugs and Women: Efficacy, Reproductive Health, Pregnancy, and Fetal Outcome (1996)

As new antiepileptic drugs (AEDs) become available, physicians will define their appropriate use in particular patient populations. For women, the issues include gender-specific efficacy and tolerability, including the impact of the AED on reproductive health. Women with epilepsy who are treated with established AEDs appear to be at risk for compromised bone health, for disturbances in fertility, menstrual cyclicity, ovulatory function, and sexuality and, with some AEDs, for failure of hormonal contraception. Finally, pregnancy outcome may be adversely affected by the established AEDs, all of which are human teratogens. Felbamate (FBM), gabapentin (GBP), lamotrigine (LTG), oxcarbazepine (OCBZ), tiagabine (TGB), topiramate (TPM), and vigabatrin (VGB) were reviewed. The preclinical development process had not addressed all the issues of concern to women. Although gender-specific efficacy is routinely evaluated, impact on reproductive health is not. FBM, GBP, LTG, TGB, TPM, and VGB have similar efficacy in women and men. It is not known whether the new AEDs will affect bone health, fertility, the menstrual cycle, and sexuality. FBM, GBP, LTG, TGB, and probably VGB do not interfere with hormonal contraception. Whether these new AEDs are good choices for the pregnant woman with epilepsy awaits further experience in human pregnancy. However, animal reproductive toxicology studies appear promising. The limited number of human pregnancy exposures do not, thus far, signal a significant number or particular type of adverse outcomes. However, only with improved postmarketing surveillance can essential information about teratogenic effects by acquired in an acceptably short time.
Validity of the Montreal Cognitive Assessment for traumatic brain injury patients with intracranial haemorrhage (2013)

MoCA is a useful and psychometrically valid tool for the assessment of gross cognitive function in tICH patients.
Photo-induced phenomena in organic field-effect phototransistors based on conjugated polymer/fullerene blends and organic dielectric (2006)

Photo-induced phenomena were investigated in photoresposive organic field-effect transistors (photOFETs) based on conjugated polymer/fullerene solid-state mixtures as active semiconductor layer and divinyltetramethyldisiloxane-bis(benzocyclobutene) (BCB) as gate dielectrics. The devices were characterized both in under dark showing n-type transistor behaviour with linear and saturated mobility of 1.7 x 10<sup>-3</sup> cm<sup>2</sup>/Vs and 2.7 x 10<sup>-2</sup> cm<sup>2</sup>/Vs respectively, and under white light illumination condition, where large shifts in the threshold voltage in the transfer characteristics were obtained. A typical phototransistor behaviour in a wide range of illumination intensities are observed in these devices.
3-Deoxy-<scp>d</scp>-<i>m</i><i>yo</i>-inositol 1-Phosphate, 1-Phosphonate, and Ether Lipid Analogues as Inhibitors of Phosphatidylinositol-3-kinase Signaling and Cancer Cell Growth (1998)

ADVERTISEMENT RETURN TO ISSUELetterNEXT3-Deoxy-d-myo-inositol 1-Phosphate, 1-Phosphonate, and Ether Lipid Analogues as Inhibitors of Phosphatidylinositol-3-kinase Signaling and Cancer Cell GrowthLixin Qiao, Fajun Nan, Mark Kunkel, Alfred Gallegos, Garth Powis, and Alan P. KozikowskiView Author Information Drug Discovery Program, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, D.C., 20007, and Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724 Cite this: J. Med. Chem. 1998, 41, 18, 3303–3306Publication Date (Web):August 8, 1998Publication History Received27 April 1998Published online8 August 1998Published inissue 1 August 1998https://pubs.acs.org/doi/10.1021/jm980254jhttps://doi.org/10.1021/jm980254jrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views467Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antitumor activity,Ethers,Hydrolysis,Lipids,Peptides and proteins Get e-Alerts
A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense (2017)

Acute respiratory virus infections predispose the cystic fibrosis (CF) lung to chronic bacterial colonization, which contributes to high mortality. For reasons unknown, respiratory virus infections have a prolonged duration in CF. Here, we demonstrate that mice carrying the most frequent cystic fibrosis transmembrane conductance regulator (CFTR) mutation in humans, ΔF508, show increased morbidity and mortality following infection with a common human enterovirus. ΔF508 mice demonstrated impaired viral clearance, a slower type I interferon response and delayed production of virus-neutralizing antibodies. While the ΔF508 mice had a normal immune cell repertoire, unchanged serum immunoglobulin concentrations and an intact immune response to a T-cell-independent antigen, their response to a T-cell-dependent antigen was significantly delayed. Our studies reveal a novel function for CFTR in antiviral immunity and demonstrate that the ΔF508 mutation in cftr is coupled to an impaired adaptive immune response. This important insight could open up new approaches for patient care and treatment.
<title>Photoelectronic Radiology Department</title> (1981)

The University of Arizona Department of Radiology first considered establishing a photoelectronic radiology department in 1973. It seemed clear that the technology had progressed far enough for us to investigate the possibility of total film replacement.' Data from the space program in particular indicated at that time that sophisticated television images over 1000 x 1000 lines were approaching the detail seen on the traditional x-ray film. This technology has been known over many years of research and development as "photoelectronic imaging devices (PEID) ."14 However, at that time film replacement was out of the question. What was not out of the question was the consideration of using a subtraction technique, "digital video subtraction angiography." To this end, we, and independently the University of Wisconsin,314 proceeded to develop this technology.5'6 Our intravenous video subtraction images in patients started in our research laboratory in 1977 and in March of 1980 we opened a biplane special procedures room dedicated only to photoelectronic imaging (no film).7'8 Digital video subtraction angiography has been successful and is described in much greater detail in these Proceedings by other authors. Current efforts are under way toward total replacement of film. This is an immense problem, one that will require a much greater sophistication of computers, storage devices, system analysis, and cooperation from both the radiologist and the clinician.9'10 In a theoretical study we converted our 65,000 procedures-per-year department to complete photoelectronic imaging (no film) and estimated that we would save approximately five million dollars over ten years.15 Extrapolating this to the entire United States would result in a conservative estimate of saving one billion dollars per year. Not included in these mathematics are cost-effective savings of the physicians' time and effort.
High Power RF Generation by Compression of Frequency Modulated Pulses (2003)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. D. R. Phelps, S. V. Samsonov, G. C. Burt, G. G. Denisov, A. W. Cross, V. L. Bratman, W. He, K. Ronald, H. Yin; High Power RF Generation by Compression of Frequency Modulated Pulses. AIP Conf. Proc. 1 December 2003; 691 (1): 166–171. https://doi.org/10.1063/1.1635117 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Naiad (2013)

Naiad is a distributed system for executing data parallel, cyclic dataflow programs. It offers the high throughput of batch processors, the low latency of stream processors, and the ability to perform iterative and incremental computations. Although existing systems offer some of these features, applications that require all three have relied on multiple platforms, at the expense of efficiency, maintainability, and simplicity. Naiad resolves the complexities of combining these features in one framework.
A Deblocking Algorithm Using Anisotropic Diffusion for Block DCT-based Compressed Images (2005)

In this paper, a new anisotropic diffusion based on Alvarez, Lions, and Morel (ALM) diffusion model is proposed for the suppression of blocking artifact caused by discrete cosine transform (DCT) based image compression. The proposed diffusion model, which incorporates a 'rate control parameter' (RCP), makes it possible to reduce blocking artifacts while to preserve the edge. The RCP controls the rate between isotropic and anisotropic diffusion. Isotropic diffusion is encouraged to eliminate the blocking artifacts in a block boundary of a smooth region, while anisotropic diffusion is encouraged to keep the edge or texture sharp in edge and a block boundary within an edge region. Additionally, to avoid oversmoothness of the texture region, a 'speed control parameter' (SCP), which makes diffusion process slow in the texture region, is employed.
Unifying Method for Computing the Circumcircles of Three Circles (2002)

Given a set of three generator circles in a plane, we want to find a circumcircle of these generators. This problem is a part of well-known Apollonius' 10 th Problem and is frequently encountered in various geometric computations such as the Voronoi diagram for circles. It turns out that this seemingly trivial problem is not at all easy to solve in a general setting. In addition, there can be several degenerate configurations of the generators. For example, there may not exist any circumcircle, or there could be one or two circumcircle(s) depending on the generator configuration. Sometimes, a circumcircle itself may degenerate to a line. We show that the problem can be reduced to a point location problem among the regions bounded by two lines and two transformed circles via Mobius transformations in a complex space. The presented algorithm is simple and the required computation is negligible. In addition, several degenerate cases are all incorporated into a unified framework.
8D display (2012)

magine a display that behaves like a window. Glancing through it, viewers perceive a virtual 3D scene with correct parallax, without the need to wear glasses or track the user. Light that passes through the display correctly illuminates the virtual scene. While researchers have considered such displays, or prototyped subsets of these capabilities, we contribute a new, interactive, relightable, glasses-free 3D display. By simultaneously capturing a 4D light field, and displaying a 4D light field, we are able to realistically modulate the incident light on rendered content. We present our optical design, and GPU pipeline. Beyond mimicking the physical appearance of objects under natural lighting, an 8D display can create arbitrary directional illumination patterns and record their interaction with physical objects. Our hardware points the way towards novel 3D interfaces, in which users interact with digital content using light widgets, physical objects, and gesture.
Stereoselective hydrolysis of<i>O</i>-acetyl propranolol as prodrug in human serum (1990)

A direct high-performance liquid chromatographic method was developed for the assays of the enantiomers of O-acetyl propranolol. Using this procedure, the stereochemical characteristics on hydrolysis of racemic O-acetyl propranolol as a prodrug have been studied in phosphate buffer (pH 7.4) and in 90% human serum. In the phosphate buffer, no difference in the hydrolysis rate between the esters of (R)- and (S)-propranolol was observed. In 90% human serum, the hydrolysis of the esters was accelerated, and the hydrolysis rate of the ester of (R)-isomer was about three times faster than that of the ester of (S)-isomer. The interconversion between (R)- and (S)-isomer was not observed during the hydrolysis of prodrug in buffer and in human serum. These results indicated that hydrolysis of O-acetyl propranolol occurs stereoselectively in human serum.
Photophysical poperties of Schiff-base metal complexes (2003)

The photophysical behaviour of Schiff-base complexes with several different metals has been investigated. Among these complexes, the one with aluminium (3) presents interesting features, showing good chemical stability, high absorption coefficients and fluorescence quantum yield. In addition, the fluorescence intensity of 3 udergoes appreciable changes in the presence of coordinating species, such as carboxylate anions, allowing the association process to be monitored with high sensitivity. In addition, we have demonstrated that, if suitable groups are attached to the carboxylate function, supramolecular systems with interesting properties can be designed and characterised.
The historic precedence of peers (1876)

The historic precedence of peers Get access Joseph Fisher Joseph Fisher Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s5-VI, Issue 144, 30 September 1876, Pages 269–270, https://doi.org/10.1093/nq/s5-VI.144.269 Published: 30 September 1876
6′‐Methylpyrido[3,4‐b]norhomotropane: Synthesis and Outstanding Potency in Relation to the α4β2 Nicotinic Receptor Pharmacophore Model. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Comparison of Pd-only vs. Pd-Rh Catalysts: Effects of Sulfur, Temperature and Space Velocity (1999)

<div class="htmlview paragraph">The relative NOx performance of Pd-only and Pd-Rh catalysts has been investigated under a series of operating conditions on a vehicle and in a laboratory reactor. The vehicle data indicates that the choice of Pd-only vs. Pd-Rh technology should be specific to the operating conditions found on that vehicle. Under low temperature conditions, Pd-Rh and Pd-only catalysts have similar NOx performance attributes. However, high temperature portions of the drive cycle accentuate the differences between Pd-only and Pd-Rh catalysts and lead to a large NOx performance advantage for the Pd-Rh catalyst. Laboratory reactor data indicates that these differences in activity are tied to the poisoning effects of reduced sulfur species on Pd, which become more severe as the temperature is increased and as the gas-phase stoichiometry becomes richer.</div>
Transverse modulational instabilities in the presence of stimulated rotational Raman scattering with a high power laser (1993)

When high energy laser beams are focused into spatial filters, small amounts of stimulated rotational Raman scattering (SRRS) can be generated providing a seed for this process later in the system.
Unification of dynamical decoupling and the quantum Zeno effect (6 pages) (2004)

Bessel functions of the first kind are ubiquitous in the sciences and engineering in solutions to cylindrical problems including electrostatics, heat flow, and the Schrödinger equation. The roots of the Bessel functions are often quoted and calculated, but the maxima and minima for each Bessel function, used to match Neumann boundary conditions, have not had the same treatment. Here we compute 10000 extrema for the first 600 orders of the Bessel function <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>J</mml:mi></mml:math> . To do this, we employ an adaptive root solver bounded by the roots of the Bessel function and solve to an accuracy of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mn>10</mml:mn> <mml:mrow><mml:mo>-</mml:mo> <mml:mn>19</mml:mn></mml:mrow> </mml:msup> </mml:math> . We compare with the existing literature (to 30 orders and 5 maxima and minima) and the results match exactly. It is hoped that these data provide values needed for orthogonal function expansions and numerical expressions including the calculation of geometric correction factors in the measurement of resistivity of materials, as is done in the original paper using these data.
Reaction of the gold–methyl bond (1972)

Olefin and acetylene complexes of a methyl gold(I) compound have been isolated; they are believed to be important intermediates in further reactions of the methylgold bond.
Experimental Methods in Attitude Control (2011)

CubeSats are miniature satellites used in various spacecraft applications, such as remote sensors, tethers, and biological experiments. Their low cost and small size allows these satellites to be good candidates for new research investment. These pico-satellites have the potential to revolutionize space operations in commercial industry, educational research, and governmental projects. Many CubeSats mainly rely on permanent magnets or magnetic coils for attitude control, while others lack an attitude control system entirely. The space environment mandates the need for orientation control, and pointing accuracy has become essential in the success of space missions dealing with such tasks as observation, data collection, and/or communication. The proposed solution, as stated in this paper, is to utilize commercially manufactured DC motors as actuators to mitigate the lack of attitude control. Conventional radio-controlled servomechanisms contain miniaturized, sophisticated, and inexpensive technology; their effectiveness as actuators was tested in a microgravity environment with mild success. Future successful flights may demonstrate that the approach considered provides a low-cost and highly effective solution to pico-satellite attitude control.
Donor-specific anti-HLA antibodies detected by Luminex: predictive for short-term but not long-term survival after heart transplantation (2013)

In heart transplantation, the clinical significance of pretransplant donor-specific antibodies (DSA) detected by solid phase assay (SPA), which is more sensitive than the conventional complement-dependent cytotoxicity (CDC) assays, is unclear. The aim was to evaluate SPA performed on pretransplant sera for survival after heart transplantation. Pretransplant sera of 272 heart transplant recipients were screened for anti-HLA antibodies using CDC and SPA. For determination of pretransplant DSA, a single-antigen bead assay was performed. The presence of anti-HLA antibodies was correlated with survival. Secondary outcome parameters were acute cellular rejection, graft coronary vasculopathy and ejection fraction. In Kaplan-Meier analysis, SPA-screening did not predict survival (P = 0.494), this in contrast to CDC screening (P = 0.002). However, the presence of pretransplant DSA against HLA class I was associated with decreased short-term survival compared to non-DSA (P = 0.038). ROC curve analysis showed a sensitivity of 76% and specificity of 73% at a cutoff of 2000 MFI. In contrast, the presence of anti-HLA antibodies had no influence on long-term survival, rejection incidence, and graft function. Thus, detection of DSA class I in pretransplant serum is a strong predictor of short-term, but not long-term survival and may help in the early management of heart transplant patients.
Identification of the gene (aphA) encoding the class B acid phosphatase/phosphotransferase of Escherichia coli MG1655 and characterization of its product (1997)

An open reading frame located in the tyrB-uvrA intergenic region of the Escherichia coli MG1655 chromosome was identified as encoding the class B acid phosphatase of this species on the basis of cloning and expression experiments. A protocol for purification of the enzyme (named AphA) was developed, and its properties were analyzed. The enzyme is a 100-kDa homotetrameric protein which apparently requires a metal co-factor for activity. Similarly to other bacterial class B acid phosphatases, it is able to dephosphorylate several organic phosphomonoesters as well as to catalyze the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds.
Direct observation of bubble-assisted electroluminescence in liquid xenon (2015)

Bubble formation in liquid xenon underneath a Thick Gaseous Electron Multiplier (THGEM) electrode immersed in liquid xenon was observed with a CCD camera. With voltage across the THGEM, the appearance of bubbles was correlated with that of electroluminescence signals induced by ionization electrons from alpha-particle tracks. This confirms recent indirect evidence that the observed photons are due to electroluminescence within a xenon vapor layer trapped under the electrode. The bubbles seem to emerge spontaneously due to heat flow from 300K into the liquid, or in a controlled manner, by locally boiling the liquid with resistive wires. Controlled bubble formation resulted in energy resolution of σ/E~7.5% for ~6,000 ionization electrons. The phenomenon could pave ways towards the conception of large-volume 'local dual-phase' noble-liquid TPCs.