gebhart/patrepeval huggingface dataset:
Preliminary study on osteoarthritis which is accompanied by the cold Zheng and the thirteen immune genes (2005)

Objective:To study the genes different expression by the cDNA microarray responsing to the heat puncture of osteoarthritis which is accompanied by the cold Zheng.In order to explore the curative effect of individuality medicine and methods of evaluation.Methods:Selected patients who have the deficiency syndrome of kidney yang by clinical observation and harvested their blood to extract mRNA,then rewersly transcripted them to cDNA,which were labeled by cy-3-dUTP.After the patients taking the treatment of heat puncture for half a month,their blood was harvested again and this time the cDNA were labeled by cy5-dUTP.These probes were hybridized with the cDNA microarrays,scanned and analyzed.Results:The curative effect mark of cold Zheng is 28.The result demonstrates that there are 57 differentia genes,including up regulated and down regulated.In the 57 differentia genes,there are 33 recognized genes.13 of the recoginzed genes are related to immunity.Conclusion:By using cDNA microarrays,we found the osteoarthritis with Han Zheng genes involve extensive expression especially the genes on immunity and we have studied the whole mechanism of Han Zheng,explore the curative effect of individuality medicine and methods of evaluation.
Interactions (1988)

Abstract The current predominant form of organization in academic libraries is the hierarchy. As academic library administrators and librarians reconsider the professional role of librarians, alternatives to the hierarchy are occurring. One alternative is the matrix organization, a cross-functional, collegial group structure. In this paper, a case study is presented on the transition of the library faculty at California State University, Lon Beach (CSULB) from a hierarchical organization to a matrix. The case study includes an insight into how a library faculty group in the matrix organization contributes to an academic program of the university. This is accomplished through a discussion of the interactions of the Administration and Management Library Faculty Group with the clientele of the Graduate Center for Public Policy and Administration, CSULB.
Reflections on the Efficacy of Pertussis Vaccines (1987)

The literature on the protection imparted by conventional whole-cell pertussis vaccines was reviewed, and the extent to which the great variation in estimates of vaccine efficacy is attributable to methodologic problems in study design and analysis or to biologic features of the natural history of pertussis was explored. The protection against disease imparted by pertussis vaccines may be greater than that against infection. Estimates of vaccine efficacy from case-control studies are higher than those from studies of household secondary-attack rates; likewise, estimates of efficacy are higher when based on clinically severe or bacteriologically positive cases rather than simply on notified cases. Some of the reported differences in protection by different vaccines may be attributable to relations between the antigenic composition of the vaccine used and that of the circulating strain of Bordetella pertussis. Failure to consider age trends has sometimes led to spuriously high estimates of efficacy. Many biases can affect efficacy studies, and it is usually difficult to assess whether the net effect has been to underestimate or to overestimate "true" efficacy. The immunity imparted by conventional pertussis vaccines may be neither as solid nor as stable as that imparted by many live-virus vaccines. These issues must be considered during the evaluation of acellular pertussis vaccines.
The Influence of Neutral Flow Rate in the Operation of Hall Thrusters. (2009)

Neutral flow dynamics in Hall thrusters are not often regarded as a critical aspect that controls thruster operation and discharge channel physics. This dissertation, combined with previous work, showed that neutral flow dynamics affect global properties including thruster performance, stability, thermal margin, and lifetime. In addition, the neutral flow rate, and more importantly, the electron-neutral collision rate in the channel have an impact on other thruster properties including the location, size, and intensity of the ionization, high electron temperature, and acceleration regions. The results of these findings are relevant to ongoing efforts to understand thruster operation, electron physics, and thruster lifetime. Performance and plume measurements indicated that thruster efficiency remained constant from ± 50% of the nominal flow rate of 20 mg/s. Current utilization was the primary loss mechanism and it decreased with flow rate due to increased ionization losses and electron-wall losses. To compensate, the divergence and mass utilizations increased with flow rate through a more compact ionization region and increased ionization efficiency from the increasing neutral density. Electron collision frequencies and the electron Hall parameter were calculated from measurements of the ion density, electron temperature, and electric field inside the discharge channel. The peak Hall parameter moved downstream and decreased in magnitude as flow rate was increased, and the results confirmed that there exist at least three distinct electron mobility regions as implemented in some plasma simulations. Near the anode, the turbulence was approximated by the Bohm value. Near the channel exit, the turbulence was suppressed and electrons were most effectively trapped by the Hall current in this region. In the plume, the turbulence was an order of magnitude greater than the Bohm value, indicating large contributions to electron transport from turbulence or a currently unaccounted for anomalous transport mechanism. For most of the channel, the electron-neutral collisions were the primary contributor to electron energy loss and cross-field mobility. However, near the channel exit, electron-wall collisions increased and became the primary contributor to the measured decrease in electron temperature with increased flow rate.
Successful establishment of patient-derived tumor xenografts from gastrointestinal stromal tumor-a single center experience. (2016)

Patient-derived tumor xenografts (PDTX) generally represent a kind of more reliable model of human disease, by which a potential drugs' preclinical efficacy could be evaluated. To date, no stable gastrointestinal stromal tumor (GIST) PDTX models have been reported. In this study, we aimed to establish stable GIST PDTX models and to evaluate whether these models accurately reflected the histological feature of the corresponding patient tumors and create a reliable GIST PDTX models for our future experiment. By engrafting fresh patient GIST tissues into immune-compromised mice (BALB/c athymic mice), 4 PDTX models were established. Histological features were assessed by a qualified pathologist based on H&E staining, CD117 and DOG-1. We also conduct whole exome sequencing(WES) for the 4 established GIST PDTX models to test if the model still harbored the same mutation detected in corresponding patient tumors and get a more intensive vision for the genetic profile of the models we have established, which will help a lot for our future experiment. To explore the tumorigenesis mechanism for GIST, we also have a statistical analysis for the genes detected as nonsynchronous-mutated simultaneously in 4 samples. All 4 GIST PDTX models retained the histological features of the corresponding human tumors, with original morphology type and positive stains for CD117 and DOG-1. Between the GIST PDTX models and their parental tumors, a same mutation site was detected, which confirmed the genetic consistency. The stability of molecular profiles observed within the GIST PDTX models provides confidence in the utility and translational significance of these models for in vivo testing of personalized therapies. To date, we conducted the first study to successfully establish a GIST PDTX model whose genetic profiles were revealed by whole exome sequencing. Our experience could be of great use.
A computer based, four terminal impedance measuring system for low frequencies (designed for plasma membrane of living cells) (1975)

A four terminal high precision measuring system is described for the determination of capacitance, C, and conductance, G, at very low frequencies (0.1-1000 Hz). The method, which offers both speed (close to the theoretical upper limit) and accuracy (phase +or-0.01 degrees , impedance amplitude +or-0.1%) was specifically designed for the investigation of the dispersion of C and G in the plasma membrane of living cells. The system, with minor modifications should, however, also find application elsewhere. The system described was designed around a small computer which is used, via analogue-digital and digital-analogue converters and digital interfaces to both control and measure the frequency and amplitude of the AC signals and to measure the AC potential appearing across the impedance under test. After the data for a complete set of programmed frequencies has been collected the analysis of the data points for current and voltage, which may be accumulated in memory over a specified number of cycles, yields the relative phase and amplitude of the current and voltage and hence C and G.
Photoinduced nucleation in supersaturated mercury vapor (1998)

Photoinduced nucleation of mercury vapor is studied experimentally in an upward thermal diffusion cloud chamber. The rate of nucleation is greatly increased when the supersaturated vapor is illuminated with light absorbed by the vapor molecules. In analogy to ion-induced nucleation the photoinduced nucleation can be explained as a general effect for all condensing atoms or molecules forming long living electronically excited states.
Baseline Precision Results Using Triple Frequency Partial Ambiguity Sets (2004)

The imminent arrival of a European satellite constellation called Galileo and the modernisation of the Global Positioning System (GPS) provide an opportunity for satellite-based positioning employing an integrated (GPS+Galileo) and/or triple frequency positioning solution. Taken together they are anticipated to have a positive impact on fast ambiguity resolution, hopefully over longer distances than are currently achievable with GPS alone. Additionally, Australia has the unique opportunity to receive broadcast signals from the Japanese Quasi-Zenith Satellite System (QZSS). Simulated QZSS observations will be included in the various tests designed to explore the impact on baseline precision results. The aim of this paper is to briefly quantify the ambiguity estimation performance when using triple frequency observations from GPS, Galileo and QZSS in both single and combined system modes. The paper will show that it is often difficult to correctly resolve a large set of ambiguities (near) instantaneously, particularly when the baseline length exceeds 40km. It will then be demonstrated that resolving only part of the ambiguity set (partial ambiguity resolution) could lead to improvements in baseline precision. Two approaches to defining the partial ambiguity subset are explored: classical partial ambiguity resolution based on ordered ambiguity variances and a per-satellite approach using elevation-ordering. Finally, the paper concludes by quantifying the impact that the fail rate has in determining the size of the partial ambiguity set.
A NEW SYNTHETIC METHOD OF PROTEIN ANALOGS HAVING PERIODIC ARRANGEMENT OF AMINO ACIDS (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA NEW SYNTHETIC METHOD OF PROTEIN ANALOGS HAVING PERIODIC ARRANGEMENT OF AMINO ACIDSJunzo Noguchi and Tadao HayakawaCite this: J. Am. Chem. Soc. 1954, 76, 10, 2846–2848Publication Date (Print):May 1, 1954Publication History Published online1 May 2002Published inissue 1 May 1954https://pubs.acs.org/doi/10.1021/ja01639a083https://doi.org/10.1021/ja01639a083research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measuring Shear Wave Velocity Using Bender Elements (2005)

Abstract The use of bender element to measure shear wave velocity is popular due to its simplicity. However, there are still some uncertainties in the interpretation of the bender element test. In this paper, the use of bender elements in the determination of shear wave velocities of dry, unsaturated, and saturated soil specimens is examined with respect to the characteristics of the bender elements, waveform, magnitude, and frequency of the applied voltage to the transmitter bender element and method of travel time determination. The interpretation of the bender element test can be improved if two performance criteria are adopted: (1) a signal-to-noise ratio of at least 4 dB for the receiver signal, and (2) a wave path length to wavelength ratio of at least 3.33. Procedures to estimate the strain level associated with the shear wave velocity measurement using bender element are also described.
Direct Measurement of the Adsorption Kinetics of Alkanethiolate Self-Assembled Monolayers on a Microcrystalline Gold Surface (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect Measurement of the Adsorption Kinetics of Alkanethiolate Self-Assembled Monolayers on a Microcrystalline Gold SurfaceD. S. Karpovich and G. J. BlanchardCite this: Langmuir 1994, 10, 9, 3315–3322Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/la00021a066https://doi.org/10.1021/la00021a066research-articleACS PublicationsRequest reuse permissionsArticle Views3331Altmetric-Citations431LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermally and electrically switchable gratings based on polymer-ball-type polymer-dispersed liquid-crystal films (2002)

We focus on the fabrication and study of controllable holographic gratings based on azo-dye-doped and undoped polymer-ball-type polymer-dispersed liquid-crystal films. Experimental results indicate that the next step of photopolymerization of the sample with the illumination of Ar+ laser beams after UV curing causes a latent density grating to be recorded. This grating is formed by a selective secondary photopolymerization. Heating and applying a voltage change the structure of the liquid crystal and induce the appearance of the latent grating. Diffraction efficiencies versus temperature, voltage, and state of polarization are studied for both dye-doped and undoped cells and are found to be quite different. This discrepancy is attributable to the reorientation effect of liquid crystals through their interaction with the photo-induced adsorption of the doped dyes on the surface of polymer balls in the dye-doped cell.
Human Motion Synthesis by Motion Manifold Learning and Motion Primitive Segmentation (2008)

Abstract. We propose motion manifold learning and motion primitive segmentation framework for human motion synthesis from motion-captured data. High dimensional motion capture date are represented using a low dimensional representation by topology preserving network, which maps similar motion instances to the neighborhood points on the low dimensional motion manifold. Nonlinear manifold learning between a low dimensional manifold representation and high dimensional motion data provides a generative model to synthesize new motion sequence by controlling trajectory on the low dimensional motion manifold. We segment motion primitives by analyzing low dimensional representation of body poses through motion from motion captured data. Clustering techniques like k-means algorithms are used to find motion primitives after dimensionality reduction. Motion dynamics in training sequences can be described by transition characteristics of motion primitives. The transition matrix represents the temporal dynamics of the motion with Markovian assumption. We can generate new motion sequences by perturbing the temporal dynamics. 1
Adult diffuse gliomas produce mRNA transcripts encoding EGFR isoforms lacking a tyrosine kinase domain (2011)

The epidermal growth factor receptor (EGFR) gene encodes four alternatively spliced mRNA, variants 1, 2, 3 and 4, respectively, encoding the whole isoform a (EGFR) and truncated isoforms b, c and d, all of which lack the receptor's intracellular domain. In addition, a mutant EGFRvIII differs from isoform a in a truncated extracellular domain. The expression pattern of these isoforms is unknown in adult diffuse gliomas. Thus, we investigated in 47 cases: i) EGFR protein expression by immunohistochemistry using an extracellular domain-recognizing antibody (Ext-Ab) and an intracellular domain specific one (Int-Ab), ii) mRNA expression of EGFRv1, -v2, -v3, -v4 and -vIII by RT-PCR and iii) EGFR amplification by fluorescent in situ hybridization. The relation of these data with histological criteria and patient outcome was studied. The immunostaining was stronger with the Ext-Ab than with the Int-Ab. EGFRv1, -v2, -v3 and -v4 mRNA expression were highly correlated. They were expressed in all tumors, with highest levels in glioblastomas. EGFRv1 strong levels and the presence of vIII mRNAs were more closely associated with Int-Ab staining. EGFR gene amplification concerned only glioblastomas and was associated with the presence of EGFRvIII and high levels of EGFRv2, -v3 and -v4 transcripts. A pejorative outcome was associated with: histology (glioblastomas), EGFR amplification, strong Int-Ab labeling and high levels of variant mRNAs. Our results indicated that the full-length EGFR and mutant EGFRvIII are not the sole EGFR isoform expressed in diffuse gliomas. This could explain discordant immunohistochemical results reported in the literature and may have therapeutic implications.
Gamma-Terpinene Modulates Acute Inflammatory Response in Mice (2015)

The monoterpene gamma-terpinene is a natural compound present in essential oils of a wide variety of plants, including the Eucalyptus genus, which has been reported to possess anti-inflammatory activity. The goal of this study was to evaluate the effect of gamma-terpinene on several in vivo experimental models of acute inflammation. Swiss mice were pretreated with gamma-terpinene and subjected to protocols of paw edema with different phlogistic agents such as carrageenan, prostaglandin-E2, histamine, or bradykinin. The microvascular permeability was measured by intraperitoneal injection of acetic acid and measuring the amount of protein extravasation. Carrageenan-induced peritonitis was used to analyze the effect of gamma-terpinene on inflammatory cell migration and cytokine production. We also developed an acute lung injury protocol to define the anti-inflammatory effect of gamma-terpinene. Mice pretreated with gamma-terpinene displayed reduced paw edema induced by carrageenan from 1-24 h after challenge. A similar reduction was observed when gamma-terpinene was administered after stimulation with PGE2, bradykinin, and histamine. Treatment with gamma-terpinene also inhibited fluid extravasation in the acetic acid model of microvascular permeability. In a carrageenan-induced peritonitis model, gamma-terpinene treatment reduced neutrophil migration as well as the production of interleukin-1β and tumor necrosis factor-α when compared to nontreated animals, and in the acute lung injury protocol, gamma-terpinene diminished the neutrophil migration into lung tissue independently of the total protein extravasation in the lung. These data demonstrate that, in different models of inflammation, treatment with gamma-terpinene alleviated inflammatory parameters such as edema and pro-inflammatory cytokine production, as well as cell migration into the inflamed site, and that this monoterpene has anti-inflammatory properties.
Release of LH in anoestrous and cyclic ewes (1977)

Reports from this and other laboratories indicate that LH may be released episodically in the intact ewe, the frequency varying according to the reproductive state of the animal (Palmer, Howland & Ibrahim, 1972; Akbar, Nett &Niswender, 1974; Foster, Lemons, Jaffe & Niswender, 1975; Yuthasastrakosol, Palmer & Howland, 1975). The purpose of the present study was to examine therefore the profile of LH secretion in ewes during anoestrus and the oestrous cycle.
Rate Constants for the Reactions of OH with HFC-245cb (CH<sub>3</sub>CF<sub>2</sub>CF<sub>3</sub>) and Some Fluoroalkenes (CH<sub>2</sub>CHCF<sub>3</sub>, CH<sub>2</sub>CFCF<sub>3</sub>, CF<sub>2</sub>CFCF<sub>3</sub>, and CF<sub>2</sub>CF<sub>2</sub>) (1997)

The rate constant for the reaction of OH with HFC-245cb (CH3−CF2−CF3) was measured by the flash photolysis resonance fluorescence technique over the temperature range 287−370 K in order to ascertain its atmospheric lifetime. Given the potential for trace levels of olefinic impurities to introduce errors into results of the rate constant measurements for low reactivity HFCs, considerable emphasis was placed on HFC purification and on demonstrating the utility of vacuum UV spectroscopy as a sensitive tool for detecting olefinic impurities in HFC samples. Measurements were also made of the OH rate constants for CH2CH−CF3, CH2CF−CF3, and CF2CF−CF3, over the temperature range 252−370 K, and for CF2CF2 at 298 K. Absorption spectra for the four fluoroalkenes as well as for ethene and propene were obtained from 160 to 220 nm.