gebhart/patrepeval huggingface dataset:
Micro power meter for energy monitoring of wireless sensor networks at scale (2007)

We present SPOT, a scalable power observation tool that enables in situ measurement of nodal power and energy over a dynamic range exceeding four decades or a temporal resolution of microseconds. Using SPOT, every node in a sensor network can now be instrumented, providing unparalleled visibility into the dynamic power profile of applications and system software. Power metering at every node enables previously impossible empirical evaluation of low power designs at scale. The SPOT architecture and design meet challenges unique to wireless sensor networks and other low power systems, such as orders of magnitude difference in current draws between sleep and active states, short-duration power spikes during periods of brief activity, and the need for minimum perturbation of the system under observation.
Branched chain DNA assay for accurate measurement of RNA in formalin-fixed tissues (2006)

A14 Background: The large resource of well-annotated formalin-fixed tissues is of limited use for prognostic and epidemiological studies because the quantification of RNA expression in archival tissues is problematic. The difficulty in measuring RNA expression arises from the extensive fragmentation and the crosslinking of RNA after formalin fixation. The branched chain DNA assay (bDNA assay) and the Quantigene® procedure are designed to overcome the adverse effects of formalin fixation. In the bDNA assay, a set of capture probes binds the RNA of interest and sequential hybridization to a strand-specific probe set and a branched DNA non-enzymatic amplifier are used for quantification of bound RNA. Here we validate the bDNA assay by comparison to qPCR.Methods: Duplicate samples from 10 different xenografts were snap frozen or fixed in formalin. Samples were prepared either by RNA isolation (pRNA) or by solubilization in a tissue homogenization buffer (thRNA). Probe sets for capture of formalin-fixed (FF) RNA were specifically designed for short RNA fragments. We measured the expression of six genes in 20 samples in parallel by qPCR and bDNA assay. For comparison of reliability between the bDNA and qPCR assays, we determined the intraclass correlation coefficient (ICC). To analyze the accuracy of the bDNA assay, we used qPCR measurements of frozen tissues as a reference and obtained correlation coefficients (ρ) directly from the variance components model. The sensitivity of bDNA assay was compared to qPCR for pRNA and thRNA sample preparations.Results: Measurements using the bDNA assay for RNA preparations from FF tissues were highly reproducible, with ICCs of six genes ranging between 0.84 and 0.97. In contrast a parallel analysis by qPCR revealed ICCs between 0.00 and 0.67. ICCs for frozen tissues ranged between 0.25 and 0.99 for bDNA and 0.64 to 0.99 for the qPCR assay. The correlation coefficients for measurements of gene expression by bDNA assay in FF and frozen tissues compared to qPCR measurements of frozen tissues were between 0.53 and 0.93 and between 0.22 and 0.93, respectively. In contrast, the correlation coefficients for measurements in frozen and FF tissue by qPCR were between -0.33 and 0.72. The sensitivity of the bDNA for quantification of pRNA in FF tissues was comparable to qPCR. However, an increased sensitivity of the bDNA assay was observed when measuring RNA in tissue homogenates.Conclusion: The bDNA permits measurements of RNA in tissue homogenates without RNA isolation and provides better reproducibility, accuracy and sensitivity than PCR-based methods.
Computational and Design Studies on the Unavailability of Mesh-restorable Networks (2000)

This paper studies the unavailability of mesh-restorable networks from the standpoint of dual-span failures as the main source of outage in networks that are efficiently designed to fully restore any single failure. Computer emulation of the detailed routing behavior of three progressively more adaptive restoration protocols is used to find the dual-failure restorability (R 2 ) under modular and nonmodular capacity assumptions. This is supplemented with two new optimization formulations to study the implications of designing for R 2 =100% and to observe the trade-off of achievable R 2 versus the total allowed investment in spare capacity. I.
Field Evaluation of Mosquito Control Devices in Southern Louisiana (2006)

The effect of 2 mosquito traps and 2 repellent systems on the catch of adult mosquitoes in American Biophysics Corporation (ABC) light traps was evaluated over a 14-month period at 3 locations in Louisiana. Devices evaluated included 1) ABC Mosquito Magnet with dry ice and octanol; 2) the BioSensory 500 cc Dragonfly Biting Insect Trap with CO2, octenol, and Mosquito Cognito, which uses Conceal inhibitor; 3) the SC Johnson OFF! Mosquito Lantern; and 4) the ThermaCell cordless mosquito repellent system. The number of adult mosquitoes caught in the ABC light traps, at the SC Johnson OFF! Mosquito Lantern, and ThermaCell cordless mosquito repellent treatment sites was significantly lower than the number collected at the ABC Mosquito Magnet or the Dragonfly/Mosquito Cognito trap system sites. When the 2 repellent devices were placed in combination with the ABC traps, mosquito numbers were significantly reduced when compared with sites with ABC traps alone. These data indicate that the SC Johnson OFF! Mosquito Lantern and ThermaCell cordless mosquito system may reduce attack from biting mosquitoes due to the reduction in their numbers. In the same study, the mosquito counts of the trapping devices also were reported.
Pharmacological testing in the laser-induced monkey glaucoma model (1985)

Glaucoma was induced in cynomolgus monkeys by photocoagulating the trabecular meshwork with the argon laser. Repeat treatments were often necessary and wide intraocular pressure fluctuations were characteristic. Baseline intraocular pressure was measured with a calibrated pneumatonometer hourly for six hours. On a succeeding day a baseline measurement was made, 50 microliter of the drug to be tested applied, and six hourly measurements of intraocular pressure repeated. The effects on intraocular pressure of timolol, epinephrine, pilocarpine, vanadate, prostaglandin F2 alpha (PGF2 alpha), forskolin, and corynanthine were tested in at least eight eyes. Significant (p less than 0.05) reductions of intraocular pressure were produced by 0.5% timolol, 2% epinephrine, 4% pilocarpine, 1% vanadate, 500 micrograms of PGF2 alpha and 1% forskolin. Five per cent corynanthine produced no significant lowering of intraocular pressure. Tonography revealed an increased outflow facility associated with the reduction of intraocular pressure 2 hours after the administration of 4% pilocarpine. This glaucoma animal model may be useful in investigating agents that lower intraocular pressure by a variety of mechanisms.
Occupational allergy in saffron workers (1997)

Sensitization to the flower of saffron, a plant commonly grown in Spain for commercial purposes, and its clinical significance as an occupational allergen were studied. The prick test and RAST, with saffron pollen, stamen, and pistil extracts, were used to evaluate the cutaneous and specific antibody responses in the studied population. Provocation tests in patients with clinical findings were used to verify the implication of saffron components in these symptoms. Fifty saffron workers were evaluated. Three of them were sensitized to saffron pollen and stamen proteins, giving prick and RAST positive values. One patient presented asthma, showing a positive bronchial provocation test, and two patients rhinoconjunctivitis, showing positive conjunctival provocation tests. Of a general allergic population of 237, 10 patients also presented cutaneous test and IgE positive to saffron. Saffron allergens (from pollen and stamens) were characterized by SDS-PAGE immunoblotting. A relevant allergen of 15.5 kDa with profilinic nature was detected and further purified by high-resolution gel filtration chromatography. No allergenic components were demonstrated in pistils. Cross-reactivity of saffron extracts was evaluated by RAST inhibition with respect to other pollen species commonly causing sensitization in the same area of study. A significant degree of cross-reactivity was demonstrated between saffron and Lolium, Salsola, or Olea. The identification of the protein components involved in the cross-reactions was investigated by blot inhibition.
Finnish software radio programme and demonstrator (2005)

This article describes the developments in the field of emerging new military radio systems to be deployed in Finland. This paper describes the evolution path toward Finnish software radio. The Finnish software radio programme has been divided into several phases to manage research and development risks and currently the program is in its demonstrator phase Finnish software radio demonstrator programme (FSDR). The demonstrator platform, that is being build, is a software defined radio wherein the developed wideband applications can be demonstrated. The emphasis of this paper is on the demonstrator structure and the philosophy used therein. The systems deployed on the demonstrator platform - tactical radio communication system (TRCS) and national tactical positioning system (NTPS) - are also introduced. Brief introduction of the adaptive antenna system (AAS) to be applied in the demonstrator is given.
Thermal stability of in-grown vacancy defects in GaN grown by hydride vapor phase epitaxy (2006)

We have used positron annihilation spectroscopy to study the thermal behavior of different native vacancy defects typical of freestanding GaN grown by hydride vapor phase epitaxy under high pressure annealing at different annealing temperatures. The results show that the VGa-ON pairs dissociate and the Ga vacancies anneal out from the bulk of the material at temperatures 1500–1700K. A binding energy of Eb=1.6(4)eV can be determined for the pair. Thermal formation of Ga vacancies is observed at the annealing temperatures above 1700K, indicating that Ga vacancies are created thermally at the high growth temperature, but their ability to form complexes such as VGa-ON determines the fraction of vacancy defects surviving the cooling down. The formation energy of the isolated Ga vacancy is experimentally determined.
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis (2006)

Krüppel-like factor5 (Klf5) is a zinc-finger transcription factor normally expressed in the skin. Here, we show that overexpression of Klf5 in the basal layer of the epidermis during embryogenesis affects epidermal development and disrupts epithelial-mesenchymal interactions necessary for skin adnexae formation as well as craniofacial morphogenesis. The transgenic mice exhibited exencephaly, craniofacial defects, persistent abdominal herniation and ectodermal dysplasia. Moreover, the epidermis was hypoplastic and underwent abnormal differentiation with expression of keratin8, a marker for single-layered epithelia, in the stratified epidermis. Correspondingly, we observed a downregulation of DeltaNp63 expression in the skin. Overexpression of Klf5 in adult mice led to hyperkeratosis, follicle occlusion and epidermal erosions. Further, we observed decrease and even loss of the stem cell population of bulge keratinocytes, as characterized by the expression pattern of alpha6 integrin and CD34 markers. Our data suggest a new role of Klf5 as a modulator of p63 expression and the differentiation program of epidermal cells relevant for regenerative potential of the epidermis and epithelial-mesenchymal interactions.
Effects of In Vitro Electrical Stimulation on Enhancement and Suppression of Malignant Lymphoma Cell Proliferation (1991)

The suppression and enhancement of proliferation of mouse EL4 lymphoma cells varied significantly when the cells were electrically stimulated within a narrow range of low-level direct current. With the use of platinum electrodes, the suppression characteristics were observed over a narrow range, or window, of direct currents centered at approximately 17 microA. Enhancement characteristics were observed over a broad range of low-level direct currents (approximately 0.1 to 10 microA). These results indicate that the proliferation of certain eukaryotic cells may be directly controlled by stimulation with low-level direct current.
ChemInform Abstract: SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES. XV. 5‐DIMETHYLAMINO‐2‐OXIDOISOQUINOLIN‐1‐YL DIAZOMETHANE: A NOVEL WATER‐SOLUBLE FLUORESCENT LABELING AGENT FOR NUCLEOTIDES (1980)

Abstract Aus dem Nitroisochinolin (I) wird durch Hydrolyse, Veresterung und Hydrierung das Amin (II), aus diesem durch Acylierung, Alkylierung und Reduktion der Alkohol (III) und aus (III) durch Acetylierung und Oxidation das Di‐N‐oxid (IV) hergestellt.
Synthesis and Pharmacological Properties of New 9,10-Dihydro-9,10-ethanoanthracene Derivatives (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Pharmacological Properties of New 9,10-Dihydro-9,10-ethanoanthracene DerivativesJacques R. Boissier, Roger. Ratouis, Claude. Dumont, Laurent. Taliani, and Jeannine. ForestCite this: J. Med. Chem. 1967, 10, 1, 86–91Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://pubs.acs.org/doi/10.1021/jm00313a018https://doi.org/10.1021/jm00313a018research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The multi-touch system with high applicability using tri-axial coordinate infrared LEDs (2009)

In these days, multi-touch technology becomes an important interface in various environments. However, most of multi-touch systems have a characteristic of low applicability so that it is difficult to apply to diverse applications. In this paper, we compare the main three methods of multi-touch systems, and analyze the pros and cons of these systems. By considering applicability and economical efficiency, we propose an infrared LED based system suitable to be used in multi users. To solve coordinate recognition problems in collinear in a 2-dimensional bi-axial coordinate system, we design a 2-dimensional tri-axial coordinate multi-touch system using infrared LEDs. The comparing result between two systems shows that the recognition rate in the biaxial coordinate system is 49 percent and the recognition rate in the tri-axial coordinate system is 99 percent.
HYPOTHERMIC MACHINE PERFUSION OF THE LIVER AND THE CRUCIAL BALANCE BETWEEN PERFUSION PRESSURES AND ENDOTHELIAL INJURY (2004)

P25 Aims: Hypothermic machine perfusion (HMP) provides better protection against cold-ischemic injury than cold-storage in marginal donor kidneys. Also, in liver transplantation a switch from static cold-storage to HMP could be beneficial as it would allow longer preservation times and the use of marginal donors. A critical question concerning application of HMP in liver preservation is the crucial balance between perfusion pressure and occurrence of endothelial injury. Methods: Rat livers were preserved using static cold-storage or continuous perfusion with the appropriate UW preservation solution. Cold-storage was compared to HMP preserved livers using an arterial perfusion pressure of 25 mmHg (mean) and a portal perfusion pressure of 4 mmHg (low pressure group), and to HMP at 50 mmHg and 8 mmHg perfusion, respectively (high pressure group). To stain for dead cells, the UW solution was enriched with 14.9 μM propidium iodide (PI), and with an additional 13.5 μM acridine orange, to stain for viable hepatocytes. After 24 h preservation the amount and anatomical localization of PI positive cells were assessed. Acridine orange (AO) used to stain viable hepatocytes, and the RECA-1 (rat endothelial cell antibody-1) and ED-1 (Kupffer cell marker) antibodies were used to identify which cells were PI positive. ATP levels were determined as a viability marker and to confirm that higher energy levels can be obtained with HMP than with cold-storage. Results: All livers in the cold-storage group and both HMP groups were completely perfused as shown with AO staining. Cold-storage preserved livers showed 75.1+/-6.2 dead PI positive cells per microscopic field. PI staining in the low-pressure group showed 64.4+/-7.8 and in the high-pressure group showed 93.4+/-5.9 PI positive cells per microscopic field. PI positive cells were non-parenchymal cells and correlated with the pattern found for RECA-1. The results for ED-1 staining did not correspond with the pattern found for PI positive cells. ATP levels were low after cold-storage (1.2 +/- 0.5) and significantly higher after HMP i.e. 44.5+/-5.9 (low-pressure) and 36.5+/-2.8 pmol/μg-protein (high-pressure), respectively. Conclusions: This study showed better ATP levels for HMP preserved livers in comparison to CS livers. The perfusion pressure showed a low PI-positive cell count in comparison to CS, when the HMP technique was used at a low perfusion pressure. A high HMP perfusion pressure resulted in more PI-positive cells compared to CS, indicating that the perfusion pressure is critical for HMP preservation of the liver. The PI-positive cells were found in the portal triad, sinusoids and central veins and were non-parenchymal in origin. The staining pattern with RECA-1 demonstrated that these non-parenchymal cells can be identified as endothelial cells. HMP preservation is effective for the liver with low-pressure perfusion and it is crucial to fine-tune the perfusion pressure to prevent endothelial injury.
Identification of Players Controlling Meristem Arrest Downstream of the FRUITFULL-APETALA2 Pathway (2020)

The end of the reproductive phase in monocarpic plants is determined by a coordinated arrest of all active meristems, a process known as global proliferative arrest (GPA). GPA is linked to the correlative control exerted by developing seeds and, possibly, the establishment of strong source-sink relationships. It has been proposed that the meristems that undergo arrest at the end of the reproductive phase behave at the transcriptomic level as dormant meristems, with low mitotic activity and high expression of abscisic acid response genes. Meristem arrest is also controlled genetically. In Arabidopsis (<i>Arabidopsis thaliana</i>), the MADS-box transcription factor FRUITFULL induces GPA by directly repressing genes of the <i>APETALA2</i> (<i>AP2</i>) clade. The <i>AP2</i> genes maintain shoot apical meristem (SAM) activity in part by keeping <i>WUSCHEL</i> expression active, but the mechanisms downstream of this pathway remain elusive. To identify target genes, we performed a transcriptomic analysis, inducing AP2 activity in meristems close to arrest. Our results suggest that AP2 controls meristem arrest by repressing genes related to axillary bud dormancy in the SAM and negative regulators of cytokinin signaling. In addition, our analysis indicates that genes involved in the response to environmental signals also respond to AP2, suggesting that it could modulate the end of flowering by controlling responses to both endogenous and exogenous signals. Our results support the previous observation that at the end of the reproductive phase the arrested SAM behaves as a dormant meristem, and they strongly support AP2 as a master regulator of this process.
Crystallization and Material Properties of Polyhydroxyalkanoates PHAs) (2002)

Abstract Introduction Historical Outline General Use Properties Optical Rotation of PHAs Crystalline Unit Cell and Conformation of Bacterial Poly(3HB) and Poly(3HV) Crystalline Structure of Syndiotactic Poly(3HB) Crystalline Conformation of Poly(4‐hydroxybutyrate) Crystalline Structure and Properties of MCL‐PHA Folded Chain Lamellar Single Crystals Splintering of Poly(3HB) Single Crystals by Depolymerases Molecular Chirality and Polymer Morphology Kinetics of Crystallization of PHA Thermal Degradation Crystalline Structure of Poly(3HB) Oligomers Dependence of Lamellar Thickness and T m on the Molecular Weight of Poly(3HB) Chemical Degradation of Lamellar Poly(3HB) Crystals Outlook and Perspectives Acknowledgements
The Quest for Diamond Crystal Perfection to Meet the Needs of Physics: Unrealistic Dream or Attainable Target? (2002)

The ongoing need for single crystal diamond of high quality in physics research and application, has been amply demonstrated. This need cannot be satisfied by access to natural diamonds. In recent years much progress has been made in the synthesis of diamond at high temperature and high pressure. Several interrogation methods were deployed to ascertain the crystal quality attainable for HPHT diamond. It is shown that the best of such materials can approximate in quantitative terms closely to the theoretical predictions for perfect diamond.
CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD (2012)

Autosomal dominant polycystic kidney disease (ADPKD) and other forms of PKD are associated with dysregulated cell cycle and proliferation. Although no effective therapy for the treatment of PKD is currently available, possible mechanism-based approaches are beginning to emerge. A therapeutic intervention targeting aberrant cilia-cell cycle connection using CDK-inhibitor R-roscovitine showed effective arrest of PKD in jck and cpk models that are not orthologous to human ADPKD. To evaluate whether CDK inhibition approach will translate into efficacy in an orthologous model of ADPKD, we tested R-roscovitine and its derivative S-CR8 in a model with a conditionally inactivated Pkd1 gene (Pkd1 cKO). Similar to ADPKD, Pkd1 cKO mice developed renal and hepatic cysts. Treatment of Pkd1 cKO mice with R-roscovitine and its more potent and selective analog S-CR8 significantly reduced renal and hepatic cystogenesis and attenuated kidney function decline. Mechanism of action studies demonstrated effective blockade of cell cycle and proliferation and reduction of apoptosis. Together, these data validate CDK inhibition as a novel and effective approach for the treatment of ADPKD.