gebhart/patrepeval huggingface dataset:
Advances in lung transplantation for cystic fibrosis that may improve outcome (2010)

The acceptance of marginal donors and the frequent practice of lobar transplantations allowed an increasing number of lung transplantations for cystic fibrosis over time. Concomitantly, the extensive use of thoracic epidural analgesia has increased the rate of early extubation and contributed to a trend towards a survival improvement.
Ricerca di pseudomonas aeruginosa nelle acque di dialisi quale ulteriore parametro microbiologico di qualità (2005)

Nel 1995 la Regione Lazio, con il DGR 1650, ha inteso regolamentare la manutenzione degli impianti dialitici ed i parametri chimici e microbiologici da ricercare sulle acque utilizzate per la preparazione dei liquidi di dialisi; riguardo ai parametri microbiologici sono stati stabiliti valori limite per carica batterica totale ed endotossine.\nDalla letteratura più recente, tuttavia, si osserva il persistere di episodi clinici gravi in seguito a sedute terapeutiche, il che suggerisce l’opportunità di estendere le analisi microbiologiche alla ricerca di microrganismi più specifici ed effettuare i controlli su volumi maggiori di campione. \nIn questo studio, condotto nell’arco di due anni, accanto ai parametri previsti si è voluta ricercare la presenza di batteri del genere Pseudomonas. \nDall’analisi dei risultati si è effettivamente potuto osservare contaminazione da parte di questi microrganismi su campioni considerati idonei in relazione ai parametri microbiologici ricercati secondo l’indicazione contenuta nella normativa vigente
Visualization of cyclic nucleotide binding sites in the vertebrate retina by fluorescence microscopy. (1989)

Cyclic nucleotides play a major role in cell signaling, especially in the nervous system. They act as cytoplasmic messengers in a wide range of physiological responses, but the spatial distribution of their sites of action within cells and tissues is not well-known. In the vertebrate retina, there is a class of well-characterized cGMP binding sites which control the permeability of cation channels in the rod outer segments (ROS), while cAMP is involved in several other systems in the inner retina. Biochemical studies of the cGMP-activated permeability in ROS have not distinguished between the subcellular compartments of disk and plasma membrane. By a new method using fluorescein-conjugated cyclic nucleotides, we have found strong cyclic GMP binding to the plasma membrane of the ROS, both on frozen sections of retina and in freshly isolated, leaky ROS. We also found a high density of cGMP binding sites on structures resembling the inner segment calycal processes. Little specific binding could be detected on the disk membranes or on any other retinal layer. In contrast, fluorescent cAMP did not label ROS, but gave a striking pattern of labeling on several deeper layers of the retina. These results suggest that the ROS plasma membrane has a much higher density of cGMP-controlled cation channels than the disk membranes, and point to other retinal layers where cAMP is likely to shape cellular responses. This method opens up novel morphological approaches to the study of cyclic nucleotide regulation.
Optimizing the performance of a data vortex interconnection network (2007)

The definition of the data vortex architecture leaves broad room for decisions regarding the exact design point required for achieving a desired performance level. A detailed simulation-based study of various parameters that affect a data vortex interconnection network's performance is reported. Three implementations are compared by acceptance rate, latency, and cost.
[Peut-être serez-vous quelque peu surpris...] (1965)

Lettre de J. Fontbonne a Andre Breton, datee de Paris le 24 septembre 1965.
Quatre images, une notice descriptive.
The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters (2013)

The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review, we mainly focus on the five mammalian NCBTs-NBCe1, NBCe2, NBCn1, NDCBE, and NBCn2. Each plays a specialized role in maintaining intracellular pH and, by contributing to the movement of HCO3(-) across epithelia, in maintaining whole-body pH and otherwise contributing to epithelial transport. Disruptions involving NCBT genes are linked to blindness, deafness, proximal renal tubular acidosis, mental retardation, and epilepsy. We also review AE1-3, AE4, and BTR1, addressing their relevance to the study of NCBTs. This review draws together recent advances in our understanding of the phylogenetic origins and physiological relevance of NCBTs and their progenitors. Underlying these advances is progress in such diverse disciplines as physiology, molecular biology, genetics, immunocytochemistry, proteomics, and structural biology. This review highlights the key similarities and differences between individual NCBTs and the genes that encode them and also clarifies the sometimes confusing NCBT nomenclature.
Single channel evidence for a cytoskeletal defect involving acetylcholine receptors and calcium influx in cultured dystrophic (MDX) myotubes (1996)

Single channel events that exhibited the conductance, event duration, and ion selectivity characteristics of calcium leakage activity (CLA) were recorded in association with acetylcholine receptor (AChR) activity in cultured nondystrophic myotubes. The CLA was observed in the presence or absence of acetylcholine (ACh), and at normal or elevated concentrations of calcium. In contrast to results from nondystrophic myotubes, cell-attached patches from several cultured dystrophic (mdx) myotubes exhibited 100% CLA with no AChR activity, even though ACh was present in the pipette solution. Acquisition of an inside-out patch from these membrane areas produced a profound decrease in CLA and the appearance of AChR events exhibiting typical conductance and event duration characteristics. These results suggest that CLA in dystrophic muscle is produced, in part, by unusual physical interactions between AChRs and the dystrophic cytoskeleton that are mediated by the action of intracellular modulators responsible for aggregating and stabilizing AChRs. © 1996 John Wiley & Sons, Inc.
SISTEMATIZACIÓN DE EXPERIENCIAS EN APROPIACIÓN DE CONOCIMIENTO CON CAFICULTORES DE COLOMBIA (2020)

Desde el enfoque cualitativo apoyado en la etnografía y mediante la tipología de estudio de caso se realizó la sistematización de experiencias (SE) de las reflexiones iniciales para la apropiación de los resultados de un desarrollo de investigación, entre investigadores y caficultores del Sur-Oeste de Colombia. Se buscó generar un conocimiento sobre experiencias para determinar factores sociales, culturales y ambientales que pudieran dinamizar la apropiación de conocimientos bajo la premisa de una investigación inclusiva. Para la SE del empaque biodegradable para almácigos de café, se tomaron como referentes las guías propuestas por la Organización de las Naciones Unidas para la Alimentación y la Agricultura (Acosta, 2005) y el Centro Internacional de Agricultura Tropical (Mosquera, 2010), apoyadas por talleres de acercamiento y conocimiento y entrevistas semiestructuradas que permitieron identificar, reconocer y ajustar procesos dentro de la cultura cafetera, así como su relación con el medio ambiente y la disposición de residuos sólidos. Se identificaron motivaciones familiares, grupales, en las prácticas tradicionales y el interés por capacitarse de los productores alrededor de la problemática ambiental que podrían dinamizar el proceso de apropiación. Los productores de café también reconocieron la implementación de un empaque biodegradable como estrategia apropiada y viable para mitigar la problemática ambiental. Finalmente, se pudo concluir que para alcanzar la apropiación de resultados de desarrollos de investigación en entornos rurales, es importante fortalecer la conexión entre la academia y las comunidades campesinas para proponer soluciones que fomenten el intercambio de conocimiento y no su imposición.
Measurements of the nonresonant third-order susceptibilities of gases using coherent anti-Stokes Raman spectroscopy (1987)

We report on measurements of the nonresonant third-order susceptibilities of the gases water vapor, n-butane, and propane. The susceptibilities were obtained from scanned coherent anti-Stokes Raman spectroscopy (CARS) spectra of binary gas mixtures containing N2 and each species of interest. The resonant susceptibility of N2, which served as a calibration standard for the measurements, was calculated using a modified exponential-gap model. Raman transition linewidths for the model were based on separate measurements by inverse Raman spectroscopy. We separately measured the nonresonant contributions from distant Raman transitions, predominantly C–H stretch modes. For parallel-polarized CARS configurations, the total effective nonresonant susceptibilities for propane, n-butane, and water vapor, respectively, were found to be 11.5 ± 1.4, 14.4 ± 1.8, and 2.2 ± 0.3 times that of N2 [using 8.5 × 10−18 (cm3/erg)/amagat].
Étude de la réactivité du noir de carbone avec les radicaux libres (1967)

L’étude cinétique de la réactivité du noir avec les radicaux isobutyronitrile a permis de mettre en évidence l’influence des différents paramètres, à savoir la concentration en AIBM, la température et la durée de traitement, ainsi que l’influence primordiale de l’oxygène présent dans le milieu réactionnel.
Disorientation Relations during the Early Stages of Recrystallization in Medium and Low SFE fcc Metals (2014)

The objective of this paper is to identify the predominant crystallographic relations between deformed state and recrystallized grains during the early stages of recrystallization of fcc metals with medium and low stacking fault energy. The experimental investigations, based on SEM/EBSD measurements, have focused on the transformations which occur in plane strain compressed single crystals with stable orientations. After annealing the disorientation across the recrystallization front 'defines' the final rotation by angles in the ranges of 25-35 o and 45-55 o around axes mostly grouped near the <122>, <012>, <112> and <111> directions located around the normals of all four {111} slip planes.
Bandwidth Extension of Audio Based on Partial Loudness Criteria (2006)

Most modern speech coders operate on a limited bandwidth. This tends to decrease the naturalness of the synthesized audio and often also affects the intelligibility of certain sounds. While a few wideband speech coders have been standardized, implementing them in existing systems would require significant changes to the infrastructure. One solution is to use bandwidth extension techniques that predict the high-frequency band based on low-band features. Problems arise however when the correlation between the low and the high band is insufficient for an adequate representation of the wideband signal. In this paper, we propose a novel source-filter bandwidth extension algorithm that makes use of psychoacoustic concepts to determine the perceptual benefits that a particular audio frame gains from a more exact representation of the high band. Preliminary results indicate that the proposed system performs at a lower average bit rate when compared to other similar algorithms without compromising the audio quality
Quantum-dot active regions for extended-wavelength-range GaAs-based light-emitting devices (1998)

This paper describes crystal growth techniques for achieving good electroluminescence efficiency and narrow linewidth from a GaAs-based light emitting device emitting at 1.3 micrometers . The long wavelength emission is achieved using a quantum dot active region grown by sub-monolayer In, Ga and As. Low threshold lasing at a shorter wavelength of 1.15 micrometers is achieved in a GaAs-based oxide-confined vertical- cavity laser using alternating single monolayer growth of InAs/GaAs QDs.
Magnetic Recording on Magneto-Optical Media Using Merge Type Giant Magneto-Resistive Head (2000)

TbFeCo media for perpendicular magnetic recording were developed by employing a NiP underlayer that controls the magnetic properties of a TbFeCo magnetic layer. Dynamic write-read characteristics were examined using a conventional merge-type giant magneto-resistive (GMR) head originally designed for longitudinal magnetic recording. A clear magnetic transition of 450 kFCI (kilo Flux Change per Inch), a high media signal-to-noise ratio (SNR), and acceptable overwrite properties were obtained by optimizing the magnetic properties of TbFeCo films. The thermal stability of a written bit in TbFeCo film is sufficient for practical application.
Case report: Immunohistochemical characterization of pulmonary corpora amylacea in an autopsy case, with special reference to its pathogenesis (2010)

Pulmonary corpora amylacea (PCA) is rare. We report here an autopsy case of a Japanese woman in her eighties who harbored numerous PCAs in both lungs. Multiple infarctions were found in the brainstem as the cause of her death. In an attempt to characterize these PCAs, several antibodies were used, including those to surfactant protein (SP)-A, SP-D, KL- 6, epithelial membrane antigen (EMA), pancytokeratins, and macrophages. PCAs were almost all positive for SP-A, in concentric lamellar fashion, some with niduses. Internal positivity of PCAs was observed on diastase-digested PAS reaction. Staining for SP-D was negative. More than half of the PCAs were covered by macrophages, indicating that they were foreign bodies. With regard to the pathogenesis of PCAs, we believe that SP-A is one of the important factors whether niduses are present or absent, and that SP-A is gradually deposited on the surfaces of PCAs in lamellar fashion. Our findings indicate that SP-A is required for the formation of PCAs, and suggest that pulmonary dysfunction, leading to an imbalance between the production of SP-A and its absorption, might be the cause of the deposition of PAS-positive glycoproteins and/or SP-A as PCAs.
Wetting and free surface flow modeling for potting and encapsulation. (2007)

As part of an effort to reduce costs and improve quality control in encapsulation and potting processes the Technology Initiative Project ''Defect Free Manufacturing and Assembly'' has completed a computational modeling study of flows representative of those seen in these processes. Flow solutions are obtained using a coupled, finite-element-based, numerical method based on the GOMA/ARIA suite of Sandia flow solvers. The evolution of the free surface is solved with an advanced level set algorithm. This approach incorporates novel methods for representing surface tension and wetting forces that affect the evolution of the free surface. In addition, two commercially available codes, ProCAST and MOLDFLOW, are also used on geometries representing encapsulation processes at the Kansas City Plant. Visual observations of the flow in several geometries are recorded in the laboratory and compared to the models. Wetting properties for the materials in these experiments are measured using a unique flowthrough goniometer.
Epithelial–mesenchymal Transition Phenotypes in Vertebral Metastases of Lung Cancer (2019)

Vertebral metastases of non-small cell lung cancer (NSCLC) are frequently diagnosed in the metastatic setting and are commonly identified in the thoracic vertebrae in patients. Treatment of NSCLC bone metastases, which are often multiple, is palliative, and the median survival times are 3 to 6 months. We have characterized spontaneous vertebral metastases in a brain metastases model of NSCLC and correlated these findings with epithelial-mesenchymal transition (EMT). Brain metastases were established in athymic nude mice following intracardiac injection of brain-seeking adenocarcinoma NSCLC cells. Thirty-nine percent of mice (14/36) developed spontaneous vertebral metastases, spinal cord compression, and hind-limb paralysis. Vertebral metastases consisted of an adenocarcinoma phenotype with neoplastic epithelial cells arranged in cords or acini and a mesenchymal phenotype with spindloid neoplastic cells arranged in bundles and streams. Quantitative and qualitative immunohistochemical and immunofluorescence assays demonstrated an increase in vimentin expression compared to cytokeratin expression in vertebral metastases. A correlation with EMT was supported by an increase in CD44 in vertebral metastases and parenchymal metastases. These data demonstrate a translational lung cancer metastasis model with spontaneous vertebral metastasis. The mesenchymal and epithelial phenotype of these spontaneous metastases coupled with EMT provide a conduit to improve drug delivery and overall patient survival.
The First International Workshop on Automated Program Analysis, Testing and Verification (workshop session) (2000)

Program analysis, testing and verification are key techniques for building confidence in and increasing the quality of software systems. Such activities typically cost upwards of 50% of total development costs. Automation aims to allow both reduced costs and more thorough analysis, testing and verification and is vital to keep pace with increasing software complexity.
Raman spectroscopic analysis of Tet repressor-operator DNA interaction in deuterium oxide. (1998)

Tet repressor (TetR) plays a central role in the regulation of its own gene and in that of TetA, a resistance protein against the antibiotic tetracycline (Tc). In the absence of Tc, the TetR dimer binds with two alpha-helix-turn-alpha-helix motifs to two successive major grooves of operator DNA. In order to elucidate structural features of the TetR:operator complex, we measured the Raman spectra of the TetR protein, a 18-mer oligonucleotide with sequence corresponding to TetR operator DNA, and the TetR:operator complex in D2O. The spectra confirm and extend previously obtained results in H2O: i) B-DNA conformation is conserved with only small perturbations of the backbone geometry; ii) TetR and operator DNA interact at major groove sites, as evident from intensity changes of thymine and guanine bands; iii) Minor changes of TetR secondary structure are indicated upon operator binding, and iv) Local environments of aromatic amino acids are altered in the complex. These spectroscopic findings are consistent with a molecular model proposed of the basis of genetic and biochemical studies.
Patterns meta-specification and cataloging (2006)

Writing patterns is a very important task for leveraging knowledge within an organization or in the software engineering community as a whole. Patterns are more than text, diagrams or source code. Patterns are knowledge that comes from experience. Sharing patterns is sharing knowledge. The creation of a language for pattern meta-specification and a catalog of patterns from different pattern languages described using this language is a clear step towards managing software engineering knowledge. The creation of a web-based visualization tool for the catalog makes this knowledge available to the world, allowing using, searching, linking, and discussing the patterns in the catalog.
The mannich condensation of sulfinic acid with aldehydes and carboxamides, sulfonamides, or lactams. Part IV (1967)

Abstract The carboxamides, p ‐CH 3 C 6 H 4 SO 2 CHR′NR″COR′″, the sulfonamides, p ‐CH 3 C 6 H 4 SO 2 CHR′NR″SO 2 C 6 H 5 , and the lactams, magnified image , have been prepared by condensation of p ‐methylbenzenesulfinic acid with an aldehyde and a carboxamide, a sulfonamide, or a lactam, respectively. The scope of the reaction is discussed. Infrared and PMR spectral data of the condensation products are given.
Error measures in greedy insertion simplification methods (2002)

In this work we study algorithms for obtaining simplified representations of terrain models. Terrain data is difficult to deal with, due to its complexity and size. Simplification methods are some of the techniques used to reduce its natural complexity. Among these methods, greedy insertion with vertical local error measure is considered to be the one that yields best results. In spite of its qualities, the method presents shortcomings, especially when applied to terrain with different height variation regions. We investigate the existence of better error measures to deal with this situation and propose the adoption of greedy insertion methods in which the local vertical error is modified according to the variability of the surface in a neighborhood of the point under consideration. The proposed error measure used with the greedy algorithms yields a significant improvement in the visualization process.
Zinc oxide nanoparticles-induced DNA damage in human lymphocytes (2009)

Zinc oxide (ZnO) nanoparticles (<20 nm) were synthesised by sol-gel method and characterised by X-ray diffraction (XRD). Extensive use of ZnO in sunscreens and cosmetics, and their reported photoclastogenicity has prompted us to investigate its genotoxic potential. We have assessed the ZnO-induced DNA damage, intracellular ROS generation and change in mitochondrial membrane potential (ΔΨm), employing alkaline single cell gel electrophoresis (comet assay), flow cytometry and spectrofluorometric analysis. Significant increase in the Olive tail moment (OTM-62.72) in treated lymphocytes vis-a-vis untreated control (OTM-0.78), clearly indicated the formation of ZnO nanoparticles-induced single strand breaks. Exposure of human lymphocytes to ZnO nanoparticles also resulted in significant reduction in membrane potential (ΔΨm). Enhancement in fluorescence intensity of intracellular probe 2′,7′-dichlorofluorescein (DCF), in treated cells suggested the ZnO-induced oxidative stress. Overall, the data revealed the genotoxic potential of ZnO nanoparticles and their ability to perturb the mitochondrial membrane potential, possibly through oxidative mechanism.
Channel Estimation: Unified View of Optimal Performance and Pilot Sequences (2020)

Channel estimation is of paramount importance in most communication systems in order to optimize the data rate/energy consumption tradeoff. In modern systems, the possibly large number of transmit/receive antennas and subcarriers makes this task difficult. Designing pilot sequences of reasonable size yielding good performance is thus critical. Classically, the number of pilots is reduced by viewing the channel as a random vector and assuming knowledge of its distribution. In practice, this requires estimating the channel covariance matrix, which can be computationally costly and not adapted to scenarios with high mobility. In this paper, an alternative view is considered, in which the channel is a function of unknown deterministic parameters. In this setting, the problem of designing optimal pilot sequences of smallest possible size is studied for any parametric channel model. To do so, the Cramér-Rao bound (CRB) for this general channel estimation problem is given, highlighting its key dependency on the introduced variation space. Then, the minimal size of pilot sequences and minimal value of the CRB are determined. Moreover, a general strategy to build optimal minimal length power constrained pilots sequences is given, based on an estimation of the variation space. The theoretical results are finally illustrated in a massive MIMO system context. They conveniently allow to retrieve well known previous results, but also to exhibit minimal length optimal pilot sequences for a new strategy based on a nonlinear physical model.
Development of diffusion-bonding parameters for tungsten and tantalum to steel (2024)

Abstract Not Provided