gebhart/patrepeval huggingface dataset:
Infl uence of phlebotomy on iron-related gene expression levels in the livers of patients with chronic hepatitis C (2007)

1. Galmiche JP, Bruley des Varannes S. Endoluminal therapies for gastrooesophageal refl ux disease. Lancet 2003;361:1119–21. 2. Shiefke I, Zabel-Langhening A, Neumann S, Feisthammel J, Moessner J, Caca K. Long-term failure of endoscopic gastroplication (EndoCinch). Gut 2005;54;752–8. 3. Furukawa N, Iwakiri R, Koyama T, Okamoto K, Yoshida T, Kashiwagi Y, et al. Proportion of refl ux esophagitis in 6010 Japanese adults: prospective evaluation by endoscopy. J Gastroenterol 1999;34:441–4. 4. Kinoshita Y, Kawanami C, Kishi K, Nakata H, Seino Y, Chiba T. Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese. Gut 1997;41:452–8. 5. Fujiwara Y, Higuchi K, Nebiki H, Chono S, Uno H, Kitada K, et al. Famotidine vs omeprazole: a prospective randomized multicentre trial to determine effi cacy in non-erosive gastroesophageal refl ux disease. Aliment Pharmacol Ther 2005;21 Suppl 2:10–8.
Structured Hinfinity/H- LPV filters for fault diagnosis: some new results (2009)

International audience
Fatty acid esters with short‐chain alcohols in two‐phase olive pomace oils (2003)

Abstract Two‐phase decanter olive pomace (TPOP) is the by‐product of a centrifugation system, used to produce olive oil, that separates olive oil and moist pomace. The water content in these olive pomaces is about 70%, while it was 45‐50% in the olive pomace stemming from three‐phase systems (oil, water, and pomace) and 30% in the old press system. The aim of this work is focused on quantification and changes undergone during olive pomace storage in ponds of esters of fatty acids with short‐chain linear alcohols, which can be considered as a refining loss. The results indicate that oil deterioration increases very rapidly, in particular when oil is extracted from the TPOP surface. Special attention should be paid to the storage of TPOP, establishing a maximum of 2 months in all cases.
Design and implementation of 3-D recursive digital filters by applying spectral transformations to LC filter networks (2003)

A spectral transformation technique is proposed for the design of three-dimensional recursive digital filters having planar and beam frequency responses. Circuit-theoretic concepts are used to generate stable 3-D continuous-domain networks from a corresponding one-dimensional prototype network. Implementation schemes are developed in the discrete domain that convert the 3-D analog network into a 3-D wave digital filter (WDF). The proposed 3-D discrete beam and planar filters offer significant advantages over direct-form realizations including the low-sensitivity properties of the WDF and simplicity of the structure. It is concluded that the proposed methods are well suited for VLSI hardware implementation and may be helpful in proceeding to real-time 3-D filters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new agonist of the erythropoietin receptor, Epobis, induces neurite outgrowth and promotes neuronal survival (2012)

Apart from its hematopoietic activity, erythropoietin (EPO) is also known as a tissue-protective cytokine. In the brain, EPO and its receptor are up-regulated in response to insult and exert pro-survival effects. EPO binds to its receptor (EPOR) via high- and low-affinity binding sites (Sites 1 and 2, respectively), inducing conformational changes in the receptor, followed by the activation of downstream signaling cascades. Based on the crystal structure of the EPO:EPOR(2) complex, we designed a peptide, termed Epobis, whose sequence encompassed amino acids from binding Site 1. The present study shows that the Epobis peptide specifically binds to EPOR and induces neurite outgrowth from primary neurons in an EPOR-expression dependent manner. Furthermore, Epobis promoted the survival of hippocampal and cerebellar neuronal cultures after kainate treatment and KCl deprivation, respectively. Thus, we identified a new functional agonist of EPOR with the potential to promote neuroregeneration and neuroprotection.
Performance Evaluation of Travel-Time Estimation Methods for Real-Time Traffic Applications (2010)

Travel time for an itinerary constitutes one of the most relevant roadway traffic metrics. Numerous studies have been conducted to estimate travel times on the basis of data from loop detectors. This article focuses on evaluating the performance of a set of estimation methods—algorithms that estimate route travel times using specific speed data from dual loop detectors for real-time applications, such as displaying travel times on changeable message signs. The travel-time estimates are evaluated against probe vehicle data obtained from FasTrak in the San Francisco Bay Area to determine the accuracy of the estimates. The study reveals that (a) the dispersion of travel time is often larger in off-peak periods than in peak periods for heavily congested freeways; (b) assessed against the same set of speed data, the evaluated algorithms have similar performance; (c) the accuracy of travel-time estimates on the basis of loop-detector data is better in off-peak periods than in peak periods; (d) lane-by-lane speeds from loop detectors may be used to improve travel time estimation; and (e) travel time estimation quality is more sensitive to actual sensor locations if sensors are sparse.
THE EFFECT OF FUNCTIONAL FORM ON THE ESTIMATED MARGINAL PROPENSITIES TO SPEND OUT OF FOOD STAMPS AND MONEY INCOME AND THE IMPLICATIONS FOR A CASH-ONLY FOOD STAMP PROGRAM (1990)

Using linear in the coefficients specifications (LCS), previous estimates of the marginal propensity to spend on food out of food stamps are about 4 to 5 times the MPS out of income. This magnitude implies that food expenditures would fall drastically if the program was cashed-out. The LCS and a specification of the expenditure equation based on a generalization of Roy's identity and a translog indirect utility function are estimated. The implications of these functional forms on cashing-out the Food Stamp Program are discussed.
Mechanism of polyol assisted ccp to hcp crystal phase conversion of nickel particles (2013)

The effect of different chain length glycols on the conversion of ferromagnetic ccp nickel nanoparticles to antiferromagnetic hcp structure was investigated. To be an effective crystal phase tuner, the glycol molecule must have both an ether fragment and a linear chain structure. The phase conversion was studied at reaction times up to 100 hours and temperatures between 200 and 275 °C. Under selected conditions nickel particles of pure or mixed crystal structure could be generated.
A prospective study using color flow duplex ultrasonography for abdominal perforator mapping in microvascular breast reconstruction. (2010)

Pre-operative duplex ultrasonography is a safe and reliable tool for assessing the abdominal epigastric perforators used in autologous microvascular breast reconstruction. Advantages of this technique are: it is non-invasive, it does not require contrast agent application, no radiation, and it is inexpensive when compared to other imaging modalities.
ChemInform Abstract: Comparative Study of Synthetic Pathways to 2E,4Z‐Hepta‐2,4‐dien‐1‐ol from 1‐Butyne. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Algorithm for Extracting Zonal Mean and Migrating Tidal Fields in the Middle Atmosphere From Satellite Measurements: Applications to TIMED/SABER Measured Temperature and Tidal Modeling (2004)

[1] For a data series with grid points that do not uniformly cover a whole wave cycle in both space and time, traditional least squares fitting methods will lead to biased estimates of the zonal mean and wave components as a result of aliasing between these elements. We introduce a set of formal regularity conditions to select available grid points that reduce aliasing while obtaining the zonal mean and tidal components from unevenly sampled or incomplete measurements. The algorithm is used to self-consistently investigate the effect of the zonal mean field on the seasonal variation of diurnal tide in the upper middle atmosphere using temperature measured by the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument onboard the Thermosphere-Ionosphere-Mesosphere Energetics and Dynamics (TIMED) satellite. We first unbiasly derive both the zonal mean and migrating tidal components from the measurements, then simulate the seasonal variation of the migrating diurnal tide using a spectral tidal model with the measured zonal mean as input, and finally compare the seasonal variation of the measured tide with the modeled one. The model and measurement comparisons show self-consistently and more conclusively the dominant effect of the zonal mean wind on the seasonal variation of the migrating diurnal tide in the upper middle atmosphere.
Five years' results of the German ARO 04-01 trial of concurrent 72 Gy hyperfractionated accelerated radiation therapy (HART) plus once weekly cisplatinum/5-FU versus mitomycin C/5-FU in stage IV head and neck cancer. (2012)

5512 Background: Are 6 cycles of once weekly DDP plus one cycle of 5-FU with concurrent HART superior to 2 cycles of MMC plus one cycle of 5-FU in terms of overall survival (OS) and metastases-free survival (MFS)? Methods: Eligibility: Stage IV SCC of oro(OP)- and hypopharynx(HP), KFS of ≥80% stratified for sites, N-status, grading, hemoglobin and center. The HART schedule was reported elsewhere (V.Budach, JCO 23;2005). HART was applied concurrently with DDP/5-FU at 30mg/m² days 1,8,15,22,29,36 or MMC/5-FU at 10mg/m 2 day 1+36 and for both arms with 600mg/m² 5-FU days 1-5 as 120 hrs. c.i. TVD dose prescription was 72 Gy using 3D-conformal or IMRT-TP. 364 patients were analysed using an ITT principle for OS, MFS, progression-free survival (PFS) and loco-regional control (LRC). Hazard ratio (HR) calculations were adjusted for competing risk factors. Results: Median follow-up was 48 mos. for both arms. Mean age was 55.4 years, 83/17% were male/female and 100% stage IV patients (UICC 2002). 58.5%/41.5% of all patients suffered from OP- or HP cancer, respectively. The OS and MFS at 4 years for the DDP- versus MMC-arm was 42.1% vs. 38.8% (n.s.) and 67.3% vs. 56.6% (p=.05), respectively. The LRC and PFS for the DDP versus MMC-arm was 58.6% vs. 57.2% (n.s.) and 46.4% vs. 38.7% (n.s.). Seven items recorded for acute toxicity and 9 for late morbidity showed no significant differences between the treatment arms except for creatinine for the DDP-arm (p < 0.001) using nonparametric analyses of variances for repeated measurements. The overall compliance rates for RTX were 96%, DDP: 72%, 5-FU: 97%, MMC: 86%, respectively. Conclusions: This phase III trial first establishes level IB-evidence for a once weekly DDP chemoradiation regimen. For MFS at 4 yrs., DDP/5 FU-HART is superior to MMC/5 FU HART at equal levels of acute and late radiation sequelae for both treatment arms. No significant differences were seen yet for OS, PFS or LRC. Chemoradiation with weekly DDP/5-FU or MMC/5-FU shows excellent compliance rates and can easily compete with other concurrent chemo- or bio-radiation schedules including induction TPF followed by radiation.
Critical Parameters in Current Evaluation by Magnetic Field Measurements (2004)

Current evaluation by magnetic field measurements can be usefully adopted when current direct measurements are not feasible. The same approach is also relevant to the determination of the turn number in a coil in which the electrical current is known. To this end, the solution of an inverse problem is required, entailing the knowledge of the actual disposition of the sources (cables, bar, coils, etc.). The uncertainty in the evaluation of the unknown quantities (current amplitude, turn number, etc.) is affected by several factors like the characteristics of the probes, their dimension and position, the source geometry. All these aspects and the methods for minimizing the measurement uncertainties are discussed in the present work using a suitable simulation environment. The evaluation of currents or, more in general, magnetomotive forces (mmf) by magnetic field measurements can be usefully adopted when a reduced space or a high number of conductors do not allow a direct experimental procedure. The same approach is also relevant in the power measurement when highly distorted current waveforms make unreliable the employment of amperometric transformers. The estimation of the current evolution from field measurements requires the solution of an inverse problem, entailing the knowledge of the actual arrangement of the sources (cables, bars, coils, etc.). Thus, the uncertainty associated to the estimated value of the unknown quantities (current waveform, turn number, etc.) becomes dependent, not only on the measurement uncertainties of the field meter, but also on the numerical process for the solution of the inverse problem. The paper first presents a method for the fast solution of the inverse problem; then the attention is devoted to the analysis of the uncertainty contributions associated to the current estimate due to the sensor accuracy and dimension and to the presence of a stray field (external disturbances). The error introduced by the computational procedure in the current evaluation is also discussed. Eventually, suggestions are given in order to reduce the uncertainty contributions affecting the final results. The paper is completed by some examples of application of the proposed procedure. 2 DESCRIPTION OF THE METHOD The estimation of the source characteristics from magnetic field measurements is usually performed by optimisation algorithms, which can require significant processing time. The method here proposed, taking advantage of the knowledge of the source position, is very simple and fast and it enables an on-line elaboration of the signals. The signals are expressed as a function of the magnetomotive forces through the Biot-Savart law and then are processed by a numerical algorithm, based on the Singular Value Decomposition (SVD) procedure. The measurement system makes use of a probe array with more sensors than unknowns, in order to improve the technique efficiency. Some examples, performed by a numerical simulation of the measurement system, put in evidence the method capability of accurately reproducing the current (or mmf) behaviour.
Drug Abuse and the Court (1972)

Three Massachusetts district courts, the states's lowest courts with criminal jurisdiction, are examined as to their processing of drug offenses and the use of treatment resources available to their probation officers. In one court, the East Boston District Court, drug probationers were generally supervised by one probation officer who saw them regularly, knew their problems, and had special experience in the drug field and familiarity with available treatment resources. Twelve of the eighty-four drug probationers attended a nearby independent city clinic which provided methadone detoxification, methadone maintenance, and counseling. The East Boston drug probationer most fre quently was not more than twenty-five years old, a high school graduate, no stranger to the correctional system, and acquainted with heroin, barbiturates, and, to a lesser extent, marijuana. In the second court surveyed there were twice as many drug offenses as in East Boston but fewer heroin violations. None of its probation officers was particularly knowledgeable about drugs or drug rehabilitation efforts, and no drug offender had been referred for treatment. The third district court had a full-time psychiatrist to whom its probation officers referred some drug probationers. Of the three courts, it had the smallest number of recorded drug offens es, possibly because of protective families and schools in that community. Probationers were younger and violations generally involved marijuana. As courts and their probation staffs begin to work more closely with the multiple community-based treatment programs that are now emerging, probation officers should receive special training in the supervision of drug offenders.
[Hygienic evaluation of the effectiveness of short-term suburban recreation from the viewpoint of natural climatic and demographic factors]. (1981)

The importance of recreation grew considerably with the increase of leisure time and cultural level of the workers. In our country, on the other hand, there are no complete hygienic studies on the problems of organization and necessary equipment for recreation. In that connection, hygienic-urbanization, hygienic-sociological, microclimatic and physiological studies, as well as investigations on ultraviolet radiation, level of noise and extent of air pollution in some typical recreation places (Sofia and Varna) were carried out. Better conditions were established in nature - town ourskirts environment (as regard ultraviolet radiation, noise level, degree of air pollution, temperature-humidity and radiation microclimate) and their favourable effect on the physiological functions of organism (particularly as regards thermoregulation and cardiovascular system). A dependence was also established between the population recreation needs and social-demographic and nature - climatic factors. Tangible recommendations for the improvement of the state of short-term town outskirts recreation in Sofia and Varna are proposed on the base of the results.
Effect of Mannheimia haemolytica pneumonia on behavior and physiologic responses of calves during high ambient environmental temperatures1 (2013)

The objective of this study was to determine the effect of pneumonia during conditions of high (maximum ≥ 32°C) ambient temperatures on physiological and behavioral responses of calves. Eighteen black beef heifers averaging 240 kg were blocked by BW and randomly assigned to 1 of 2 treatment groups: 1) pneumonia induced by bronchoselective endoscopic inoculation with Mannheimia haemolytica (MH; n = 10) and 2) noninoculated controls (CN; n = 8). Nasal passage and rectal temperatures were measured every 2 h for 24 h after challenge and then twice daily for 9 d. Accelerometers, pedometers, and positioning devices monitored cattle behavior within the pen for 9 d after challenge. Blood samples were collected on trial d 0, 0.5, 1, 2, 3, 7, and 9 and were analyzed to determine the concentration of substance P, cortisol, haptoglobin, and metalloproteinase. All calves in the MH group were euthanized and necropsied on trial d 9. All MH calves became clinically ill postchallenge. A treatment × time interaction (P < 0.05) was evident for nasal and rectal temperatures, behavior, weight, and blood analysis. Rectal temperatures in MH were higher (P < 0.01) than CN during the period from 6 to 24 h after challenge. Conversely, nasal passage temperatures were less in MH calves compared with CN at 12 to 22 h after challenge. Calves in MH spent less time at the grain bunk, less time at the hay feeder, and more time lying down during the early pneumonia period compared with CN calves. Also, MH calves had significantly greater concentrations of blood biomarkers of pain (substance P) on d 0.5 (P < 0.01); stress (cortisol) on d 0.5 and 1 (P < 0.01); haptoglobin on d 0.5, 1, 2, 3, 7 (P < 0.01); and metalloproteinase on d 1, 2, and 3 (P < 0.01) compared with CN calves. At necropsy, all MH calves had right cranioventral bronchopneumonia (median lung lesions = 6.8%). Mannheimia haemolytica pneumonia caused significantly more changes in behavior and increased biomarkers during high (maximum ≥32°C) ambient temperatures compared with control calves. The results of this study may guide research in the development of objective assessment tools for management of cattle affected with bovine respiratory disease during extreme summer conditions.
Logic Device Agents: Smart and highly reusable components in industrial automation systems (2010)

Control system design is a crucial point in modern automation systems, involving an increasingly broader set of activities being performed by software. Despite the availability of several domain-specific facilities, designers daily face kindred issues which actually lack reference patterns, in particular as regards the architectural organization of the control logic. In this paper we present an approach that, focusing on cross-cutting domain problems and suitably abstracting from application-specific details, leads to an effective decoupling of high-level control policies from low-level actuation and sensing mechanisms. Logic Device Agents emerge as generally applicable active components modeling the behavior of commonly used field devices, which can be profitably exploited to enhance software design quality and productivity.
SENSITIVITY ANALYSIS OF THE DIAGNOSTIC VALUE OF ENDOSCOPIES IN CROSS-SECTIONAL STUDIES IN THE ABSENCE OF A GOLD STANDARD (2000)

This method to determine the theoretically possible range of sensitivity estimates in endoscopic procedures is helpful in cross-sectional studies with a missing gold standard method. It is easily applicable for a variety of endoscopic procedures, including upper and lower gastro-intestinal tract, urogenital tract, or diagnostic laparoscopic surgery.
Inhibition of rat smooth muscle cell adhesion and proliferation by non‐anticoagulant heparins (2002)

Heparin is a well established growth inhibitor of arterial smooth muscle cells (SMCs) both in animal models and in vitro. Even though the cellular mechanisms involved in the anti-proliferative properties of heparin are being resolved, the structural requirements for the biological effects of heparin are not known in detail. Here, we have studied the effect of chemically modified heparins of different molecular weights and anticoagulant activities on proliferation and adhesion of rat aortic SMCs in vitro. The effects of native heparin (NH) and chemically modified heparins were examined after stimulation with fetal calf serum (FCS), platelet-derived growth factor BB (PDGF BB), basic fibroblast growth factor (bFGF), and heparin-binding epidermal growth factor (hbEGF) with respect to DNA synthesis and expression of phosphorylated and activated mitogen-activated protein kinase (pERK1 and 2). In a similar manner as NH, the modified heparins were capable of inhibiting activation of ERK1 and 2 and DNA synthesis induced by FCS and hbEGF whereas the modified heparins potentiated the mitogenic effect of bFGF and no compound affected PDGF BB-induced ERK activity and SMC growth. In contrast, cell adhesion to fibronectin was inhibited by NH and modified heparins in a size-dependent manner with the lowest effect by the smallest compound. The results show that heparins with varying anticoagulant activities and molecular weights but with similar sulfate content can retain anti-proliferative properties while the effect on some other biological processes such as cell adhesion is lost. Possibly, such chemical alterations may yield useful substances for the prevention of SMC proliferation after arterial injury.