gebhart/patrepeval huggingface dataset:
Distinctive anti-influenza properties of recombinant collectin 43 (2002)

Collectins play important roles in innate defence against viral, fungal and bacterial pathogens. CL-43, a bovine serum collectin, which appears to have evolutionarily evolved from surfactant protein D (SP-D), shows unique structural and functional properties. In the present study, we describe the initial characterization of a recombinant CL-43 expressed in mammalian cells. Like natural CL-43, the recombinant is secreted as trimeric forms that show a preference for mannose and N-acetyl mannosamine. The natural and recombinant proteins have significantly higher haemagglutination-inhibiting activity against influenza A virus (IAV) than recombinant trimeric forms of SP-D. In contrast with the more highly multimerized forms of SP-D, namely conglutinin or mannose-binding lectin, CL-43 did not induce viral or bacterial aggregation and did not enhance IAV-induced neutrophil H2O2 generation. Like SP-D, CL-43 also strongly enhanced neutrophil uptake of IAV. However, the mechanism of this enhanced internalization is different from that of SP-D in that it did not require viral aggregation. These studies establish that the trimeric structure of CL-43 is specified by its primary sequence and indicate that this naturally occurring trimeric collectin has unique antiviral activities. These findings could facilitate the development of recombinant collectins with novel antimicrobial properties.
Development of a RANS-Based Knock Model to Infer the Knock Probability in a Research Spark-Ignition Engine (2017)

<div class="section abstract"><div class="htmlview paragraph">Engine knock is one of the most limiting factors for modern Spark-Ignition (SI) engines to achieve high efficiency targets. The stochastic nature of knock in SI units hinders the predictive capability of RANS knock models, which are based on ensemble averaged quantities.</div><div class="htmlview paragraph">To this aim, a knock model grounded in statistics was recently developed in the RANS formalism. The model is able to infer a presumed log-normal distribution of knocking cycles from a single RANS simulation by means of transport equations for variances and turbulence-derived probability density functions (PDFs) for physical quantities. As a main advantage, the model is able to estimate the earliest knock severity experienced when moving the operating condition into the knocking regime.</div><div class="htmlview paragraph">In this paper, improvements are introduced in the model, which is then applied to simulate the knock signature of a single-cylinder 400cm<sup>3</sup> direct-injection SI unit with optical access; the engine is operated with two spark timings, under knock-safe and knocking conditions respectively. The statistical prediction of knock resulting from the presented knock model is compared to the experimental evidence for both investigated conditions.</div><div class="htmlview paragraph">The agreement between the predicted and the measured knock distributions validates the proposed knock model. Finally, limitations and some unprecedented possibilities given by the model are critically discussed, with particular emphasis on the meaning of RANS knock prediction.</div></div>
Predictive score for early preterm birth in decisions about emergency cervical cerclage in singleton pregnancies (2012)

The score and its associated early preterm probabilities may be a valuable tool to help physicians in advising women about the need for emergency cerclage.
Automatic design of magazine covers (2012)

In this paper, we propose a system for automatic design of magazine covers that quantifies a number of concepts from art and aesthetics. Our solution to automatic design of this type of media has been shaped by input from professional designers, magazine art directors and editorial boards, and journalists. Consequently, a number of principles in design and rules in designing magazine covers are delineated. Several techniques are derived and employed in order to quantify and implement these principles and rules in the format of a software framework. At this stage, our framework divides the task of design into three main modules: layout of magazine cover elements, choice of color for masthead and cover lines, and typography of cover lines. Feedback from professional designers on our designs suggests that our results are congruent with their intuition.
Combate aos ninhos do cupim Syntermes sp. com inseticidas (1976)

O presente trabalho teve como objetivo combater o cupim semisubterrneo Syntermes sp., praga de pastagens. Foram usados 6 inseticidas: foxim, fentiom, endossulfam, protoato, aldrim e fenitrotiom. Os melhores resultados foram obtidos com o fentioni e endossulfam. A aplicação das caldas inseticidas teve lugar em perfurações perpendiculares superfície do solo, feitas na parte superior dos cupinzeiros. Entre a aplicação e a escavação passaram-se 10 meses.
Influence of outdiffusion of carriers on the energy spectrum of soft x rays in semiconductor detectors (1981)

An analysis is made of the mechanism of outdiffusion of carriers to the surface of a crystal and its influence on the energy spectrum of semiconductor detectors in the soft x-ray range (1--10 keV). Expressions are obtained for calculating accurately the energy spectrum and for estimating the relative area under the tail of the spectrum when the parameters of a crystal are known.
Rapid prototyping of domain-specific architecture languages (2012)

Software architecture has become a sensitive discipline, which consists in concretizing the user requirements into a set of artifacts that can be used to model and reason about the software to be developed. However, the architect often relies on its own knowledge to map domain-specific requirements onto generic software abstractions. Most of the time, this leads to the definition of repetitive tasks and architecture fragments, which can be particularly error prone. We therefore believe that architects need a more flexible approach to cope with the definition of domain-specific architectures by leveraging general purpose architecture description languages. This paper introduces the FraSCAla framework as an adaptive architectural framework that can be used to rapidly prototype and experiment domain-specific ADLs in order to catalyze the definition and to improve the reliability of software architectures. We demonstrate the merits of this approach on two representative architectural patterns of component-based software architectures.
5,6,7,8 -Tetrahydro-1(2H)phthalazinone derivatives with potential pharmacological activity. Part I (2002)

N-cyanoethylation of 5,6,7,8-tetrahydro-1(2H)phthalazinones was performed with acrylonitrile in good yields in the presence of potassium carbonate and the cyanoethylated products were hydrolyzed to the corresponding acids. The structure of the new compounds was assigned by elemental analysis, 1 H- and 1 3 C-NMR spectra.
An Evaluation of Routing and Volume‐based Storage Policies in an Order Picking Operation (1999)

ABSTRACT Order picking, the assembly of a customer's order from items in storage, is an essential link in the supply chain and is the major cost component of warehousing. The critical issue is to simultaneously reduce the cost and increase the speed of the order picking activity. This study departs from the limited prior research that focused on either routing of workers or storage of warehoused items. The main objectives are to (1) evaluate various routing heuristics versus an optimal routine in a volume‐based storage environment, (2) propose several methods of implementing volume‐based storage, and (3) examine the interaction of the routing and storage policies under different operating conditions of pick list size and demand skewness. The experimental results show statistically significant differences in the mean route distance for the routing policies, storage policies, and their interactions. Further testing indicates that the choice of certain routing and storage policies in combination can result in increased picking efficiency.
Intracardiac ultrasonic suture welding for knotless mitral valve replacement (2002)

This new modality proved reliable in an acute sheep model of MVR and could constitute a promising avenue towards facilitation of total endoscopic valve procedures in humans.
Spray Cryotherapy for Esophageal Cancer: Long-term Results (2011)

Purpose: Early studies show endoscopic spray cryotherapy with liquid nitrogen (LN) to be safe and effective in eradicating of early esophageal cancer (Gastroint Endosc 2010; 71:686). The purpose of this study is to assess the long-term safety and efficacy of this treatment. Methods: We report long-term follow-up of a multicenter, retrospective cohort treated with LN spray cryotherapy (CSA Medical, Inc., Baltimore, MD) as primary treatment for localized esophageal cancer (T1-2, N0, M0). Patients (pts) from academic and community medical centers were treated based on failure, ineligibility, or refusal of conventional therapy. Treatment dosimetry was typically 20 second freeze for 3 cycles with at least 45 second thaws. All procedures were performed on an outpatient basis, typically every 4-8 weeks. Pts were treated until cancer (ca) was absent on biopsy, ca progressed, or comorbid conditions prevented further treatment. Some pts received additional therapy to eradicate residual Barrett's dysplasia or intestinal metaplasia. Concurrent therapies were allowed as deemed appropriate by the treating physician. Overall survival (OS) was calculated from date of first cryo treatment to death or last pt contact and estimated by the Kaplan-Meier method. Esophagectomy pts were censored on surgery date. Results: 56 pts (median age 76, 79% male, 95% adenoca) were treated. Tumor stage included T1-44: T1a (mucosal)-25, T1b (submucosal)-18, not recorded-1, T2-12. Median follow-up was 28 months (range 4-68). By stage, eradication of luminal ca, confirmed by biopsy, was seen in T1a-92%, T1b-50% (overall T1-75%), T2-25%. OS (figure) was significantly better in T1a vs T1b (p = 0.02) and T1 vs T2 (p<.01). By stage, overall survival was T1a-80%, T1b-39%, overall T1-64%, T2-17%. Median number of treatments was 3.5 (range 1-25). Previous/concurrent therapy included EMR-41%/23%, PDT-18%, concurrent chemoradiation (CR)-13%, radiation-11%/4%, APC-4%/13%, esophagectomy 0/9%, and RFA 2%/7%, stent 0/4%, brachytherapy 2%/2%, CR plus esophagectomy-2%. Stricture was seen in 10 pts. No treatment-related deaths occurred.Figure: Overall Survival by T-stage.Conclusion: Liquid nitrogen spray cryotherapy eradicates esophageal T1 mucosal cancer in 92% with 28 month median follow-up. It is less effective in T1b and T2 cancers. Disclosure: Dr. Greenwald - consultant, medical advisory board member, receives research funding from CSA Medical, Inc. Dr. Dumot - consultant for CSA Medical, Inc.
Effects of adhesive fillers on the strength of tubular single lap adhesive joints (1999)

Abstract When an adhesively bonded joint is exposed to a high environmental temperature, the tensile load capability of the adhesively bonded joint decreases because the elastic modulus and failure strength of the adhesive decrease. In this paper, the elastic modulus and failure strength of the adhesive as well as the tensile load capability of the tubular single lap adhesively bonded joint were experimentally and theoretically investigated with respect to the volume fraction of filler and the environmental temperature. Two types of fillers - Al2O3 (alumina) and chopped fiber E glass - were used. From the experiment, it was found that the elastic modulus and failure strength of the adhesive increased in accordance with the increase of volume fraction of the filler and decreased with the environmental temperature rise. It was also found that the tensile load capability of the tubular single lap adhesively bonded joint decreased as the environmental temperature increased; however, it had no correlation with the volume fraction of filler because of the effect of the fabrication thermal residual stresses generated by the CTE difference between the adherend and adhesive. Keywords: Tubular single lap adhesively bonded jointfillerresidual thermal stressCTE (coefficient of thermal expansion)
Multiple Sclerosis (2012)

Special trial designs have been developed to distinguish the symptomatic and disease modifying effects of treatment using clinical outcome measures. These designs, termed 'two-period' designs, include the so-called withdrawal and delayed-start (or 'staggered-start') designs and their variations. This chapter describes these study designs in terms of their rationale, assumptions, design features, implementation, statistical analysis, and sample size considerations. It also discusses the important limitations of the designs. Simulation studies using disease progression modeling suggest that the withdrawal design may provide more power than the delayed start design to detect disease-modifying effects of a treatment. A statistical model for data from a complete two-period design assumes that a normally-distributed outcome termed µ 2. There are alternative approaches to evaluating the disease-modifying effects of an intervention that require only a single treatment period.
Increased Cytosolic pH in Multidrug-Resistant Human Lung Tumor Cells: Effect of Verapamil (1989)

In a set of four increasingly multidrug-resistant variants of SW-1573 human lung tumor cells, the pHi (i.e., steady-state cytosolic pH) increased up to 0.44 U as a function of the level of doxorubicin resistance. The elevated pHi in the most resistant (2,000-fold) variant dropped to the control level upon addition of verapamil, a known inhibitor of P-glycoprotein activity. These data suggest that, in the absence of xenobiotic substrates, P-glycoprotein activity can affect cellular pHi. This finding may be important for the elucidation of the physiological function of this protein.
ChemInform Abstract: Oligomeric Stilbenes from Caragana chamlagu Lamark Root (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
α‐Tosylbenzyl Isocyanide (2003)

Abstract α‐tosylbenzyl isocyanide intermediate: p‐toluenesulfinic acid intermediate: N‐(α‐tosylbenzyl)formamide product: α‐tosylbenzyl isocyanide
In Situ Investigation of the Interface of Photoanodes and Electrocatalysts in Photoelectrochemical Water Oxidation Using Dual Working Electrode Photoelectrochemistry (2017)

Light-absorbing semiconductor electrodes decorated with electrocatalysts are key components of photoelectrochemical energy conversion and storage systems. Efforts to optimize these systems have been slowed by an inadequate understanding of the semiconductor (SC) and electrocatalyst (EC) interface. Experiments to directly measure the interface behavior are challenging because conventional photoelectrochemical techniques do not measure the electrocatalyst potential during operation. We developed dual working electrode (DWE) photoelectrochemistry to address this limitation. A second electrode is attached to the catalyst layer to control and probe current/voltage independent from that of the semiconductor. The DWE investigations on a model system TiO 2 reveal that electrolyte-permeable ECs form an “adaptive” junction with the semiconductor. This talk will focus on studies of the interface of the visible-light-absorbing semiconductor α-Fe 2 O 3 and the electrocatalyst a-Ni 80 Fe 20 O x with DWE photoelectrochemistry. We discover that the potential at the SC|EC interface changes in situ with the oxidation level of the EC. Additionally, the activation of EC film is vital to the charge transport between SC and EC. A fully-activated amorphous Ni(Fe)OOH film can harvest the vast majority of photo-generated holes from α-Fe 2 O 3 electrodes.
PATTERN OF OESTRIOL CONJUGATES IN HUMAN CORD BLOOD, AMNIOTIC FLUID, AND URINE OF NEWBORNS (1961)

ABSTRACT Free and conjugated oestriol (oestra-1.3.5(10)-triene-3,16α,17β-triol) were measured in extracts of human cord blood, amniotic fluid and urine of newborns and the pattern of oestriol conjugates in these body fluids was determined. The bulk of oestriol occurred in a conjugated form, with more free oestriol (12 %) in cord blood than in amniotic fluid (2.5 %) or urine of newborns (1.5%). Sodium oestriol-3-sulphate has been identified in extracts of cord blood, amniotic fluid and urine of newborns. It is the principal oestriol conjugate of the cord blood (86% of total conjugated oestriol), but is only a minor component in the amniotic fluid (15 %) or in the urine of newborns (11%). Sodium oestriol-16(17?)-glucosiduronate has been identified in extracts of amniotic fluid and urine of newborns, and partially characterized in extracts of cord blood. It constitutes some 50% of the total conjugated oestriol of the amniotic fluid and urine of newborns, but amounts only to approximately 1 % of the total conjugated oestriol of cord blood. Three additional oestriol conjugates have been detected and partially characterized in the body fluids studied. Two of them appear to be dior tri-glucosiduronates. The quantitatively most important third one is a double conjugate: possibly oestriol-3-sulphate-16 and/or 17-glucosiduronate, or oestriol-3-sulpho-glucuronide. It is suggested that transconjugation of oestriol-3-sulphate into oestriol glucosiduronates takes place in the human foetus and newborn.
Reaction between trioxodinitrate and the pentacyanonitrosylferrate(II) anion (nitroprusside) (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction between trioxodinitrate and the pentacyanonitrosylferrate(II) anion (nitroprusside)Mohammad Javaid Akhtar, Francis T. Bonner, Aidan Borer, Ian Cooke, and Martin N. HughesCite this: Inorg. Chem. 1987, 26, 26, 4379–4382Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/ic00273a021https://doi.org/10.1021/ic00273a021research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direct evaluation of reflector effects on radiant flux from InGaN-based light-emitting diodes (2007)

A metal layer formed on the backside of InGaN/sapphire-based light-emitting diodes deteriorates the inherent optical power output. An experimental approach of a suspended die is employed to study the effects of such metal layers via a direct comparison in radiant flux from a discrete die with and without a reflector. A sphere package that employs no reflector is proposed and fabricated. Light extraction of the sphere design is discussed; a light source in the sphere package would not have to be either an ideal point or placed at the center of the sphere, due to a finite critical angle at the sphere/air interface.
A neural classifier enabling high-throughput topological analysis of lymphocytes in tissue sections (2001)

A neural cell detection system (NCDS) for the automatic quantitation of fluorescent lymphocytes in tissue sections is presented in this paper. The system acquires visual knowledge from a set of training cell-image patches selected by a user. The trained system evaluates an image in 2 min calculating: the number, the positions, and the phenotypes of the fluorescent cells. For validation, the NCDS learning performance was tested by cross validation on digitized images of tissue sections obtained from inherently different types of tissue: diagnostic tissue sections across the human tonsil and across an inflammatory lymphocyte infiltrate of the human skeletal muscle. The NCDS detection results were compared with detection results from biomedical experts and were visually evaluated by our most experienced biomedical expert. Although the micrographs were noisy and the fluorescent cells varied in shape and size, the NCDS detected a minimum of 95% of the cells. In contrast, the cellular counts based on visual cell recognition of the experts were inconsistent and largely unreproducible for approximately 80% of the lymphocytes present in a visual field. The data indicate that the NCDS is rapid and delivers highly reproducible results and, therefore, enables high-throughput topological screening of lymphocytes in many types of tissue, e.g., as obtained by routine diagnostic biopsy procedures. High-throughput screening with the NCDS provides the platform for the quantitative analysis of the interrelationship between tissue environment, cellular phenotype, and cellular topology.
Minnesota multiphasic personality inventory profiles of Vietnam combat veterans with posttraumatic stress disorder and their children (1997)

Forty children of 28 fathers who are Vietnam veterans with posttraumatic stress disorder (PTSD) completed the Minnesota Multiphasic Personality Inventory. Each of the fathers had at least one elevated clinical scale. Fathers averaged eight elevated clinical scales, and compared to more recent norms, fathers averaged seven elevated clinical scales. Seventy-eight percent of the children had at least one clinically elevated scale (averaging three elevated clinical scales). Compared to contemporary normal adolescents and adults, 65% of children had at least one clinically elevated scale (still averaging three elevated clinical scales). No consistent MMPI profile patterns emerged within or across the two groups. No gender differences were detected among child MMPI profiles. Forty percent of the children reported illegal drug use, and 35% reported behavior problems. Fifteen percent of children reported previous violent behavior. Eighty-three percent of the children reported elevated Cook-Medley hostility scores as compared to an age-matched national normative sample. Children with higher PK scores were also significantly more likely to report higher Cook-Medley hostility scores. Forty-five percent of children reported significant elevations on the PTSD/PK subscales.
La opción reformista: entre el despotismo y la revolución: una explicación del capitalismo histórico a través de las luchas de clase (2014)

Este libro supone una excelente fuente de informacion y explicacion para calibrar la relacion entre procesos politicos y economicos. Para conocer las fases que ha atravesado el capitalismo, sus regimenes de acumulacion y modos de regulacion, sus bases energeticas, su evolucion historica y perspectivas futuras; las diferentes formas de dominacion resultantes, asi como las periodicas crisis capitalistas y las claves sistemicas de la geoestrategia.
Male Sex, Decreased Activity Level, and Higher BMI Associated With Lower Completion of Patient-Reported Outcome Measures Following ACL Reconstruction (2018)

An inverse relationship was found between the surgery-to-survey period and percentage of those completing PRO surveys, with poor overall compliance. Male sex and not self-identifying as an athlete or performing frequent physical exercise were associated with lower completion rates of PRO surveys, while lower body mass index was associated with a greater rate of completion.