gebhart/patrepeval huggingface dataset:
New actigraph for long‐term tremor recording (2006)

A new method of movement analysis is validated, allowing an actigraph to discriminate tremor from other movements and store duration and intensity measures of both movement types. For algorithm optimization, wrist acceleration was recorded in nine controls and nine Parkinson's disease patients, while simultaneously rating their observed tremor minute by minute on item 20 of the Unified Parkinson's Disease Rating Scale. An optimization procedure to minimize false positives in controls while maximizing tremor detection in patients resulted in false positive tremor classification in 2.4% +/- 2.5% of the movement time of control subjects (range, 0%-7%), while providing tremor classification in 82.1% +/- 15.4% of the movement time in patients (range, 55%-100%), correlating r = 0.93 with their averaged observed tremor score. A second, generalizability study showed that application of the optimized algorithm resulted in accurate classification of 71% +/- 14% of the observed tremor time (range, 46%-90%) in another 9 patients and in a false positive classification in only 0.5% +/- 0.8% of the time in another 10 controls (range, 0%-2.4%). The commercial availability of this actigraph now for the first time makes it possible to investigate tremor fluctuations over several weeks. An example is given of how long-term monitoring can be of use in evaluation of symptom management.
Two pathologic types of hepatocellular carcinoma with lymph node metastasis with distinct prognosis on the basis of CK19 expression in tumor (2008)

CK19 expression and AJCC/UICC T classification were 2 independent risk factors for developing LNM in HCC. CK19 expression was the independent prognostic factor for HCC with LNM. It is of clinical significance for treatment modalities to differentiate HCC with intrahepatic cholangiocarcinoma-like differentiation (CK19[+]) from one with a higher T classification (CK19[-]).
Electromagnetic traveltime tomography using an approximate wavefield transform (2002)

Abstract We present an imaging scheme for mapping cross-hole electrical conductivity using nonlinear traveltime tomography. Data used are peak arrival time estimates based on an approximate wavefield transform of the synthetic frequency-domain electromagnetic (EM) field. Direct transformation of frequency-domain EM fields to wavefields is known to be an ill-posed problem because the kernel of integral transform is highly damped. In this study, instead of solving such an unstable problem, we approximate the wavefield in the transformed domain via a ray series expansion. If reflected and refracted energy is weak compared to that of direct wave, picking of the peak arrival time may be reduced to estimating the coefficients of the leading term in the ray series expansion. This simplification is valid when the conductivity contrast between background medium and the target anomalous body is small. The first three terms in the expansion are identical to the closed-form solution for the vertical magnetic field caused by a vertical magnetic dipole source in a homogeneous whole-space. An adaptive simulated annealing scheme is used to estimate the coefficients of ray series. For a whole-space, exact traveltime can be extracted using only four frequency samples in our approach, whereas the direct numerical wavefield transform needed at least ten frequencies to construct a reasonable waveform. Nonlinear traveltime tomography using thusly-extracted peak arrivals from synthetic data shows a reasonable image of the conductivity structure between boreholes.
The role of pancreatic stellate cells in the microenvironment of pancreatic cancer and its research progress (2018)

Pancreatic cancer is a high malignant disease of digestive system origin. Morbidity of pancreatic cancer in China increases very fast as the diet structure of Chinese changes rapidly because of economy development. However, due to a lack of effective treatments, mortality is still at a high level with 5-year overall survival less than 5%. Local tissue within pancreas that is injured by a series of pathogenic factors gradually produces the precancerous lesion-pancreatic intraepithelial neoplasia. Oncogene is subsequently activated during the process of damage and repair, which finally leads to the occurance of pancreatic cancer. One of the most special characteristic of pancreatic cancer is that cancer cells will activate and recruit pancreatic stellate cells (PSCs), the role of which is to promote fibration and adhesion in local tissue and provide a special microenvironment of abundant matrix, hypoperfusion, hypoxia, remission of immunosurveillance. As a result, great challenge is faced on account of the special microenvironment mentioned above, and therefore, pancreatic cancer microenvironment and PSC are high promising treatment targets. Now a review of the role of microenvironment and PSC during pancreatic cancer progression and its recent research development is made as follows.


Key words: 
Pancreatic cancer; Tumor microenvironment; Pancreatic stellate cells; Pancreatic fibrosis
Oligodendrocytes: biology and pathology (2009)

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons. Due to this complex differentiation program, and due to their unique metabolism/physiology, oligodendrocytes count among the most vulnerable cells of the CNS. In this review, we first describe the different steps eventually culminating in the formation of mature oligodendrocytes and myelin sheaths, as they were revealed by studies in rodents. We will then show differences and similarities of human oligodendrocyte development. Finally, we will lay out the different pathways leading to oligodendrocyte and myelin loss in human CNS diseases, and we will reveal the different principles leading to the restoration of myelin sheaths or to a failure to do so.
Social influence based clustering of heterogeneous information networks (2013)

Social networks continue to grow in size and the type of information hosted. We witness a growing interest in clustering a social network of people based on both their social relationships and their participations in activity based information networks. In this paper, we present a social influence based clustering framework for analyzing heterogeneous information networks with three unique features. First, we introduce a novel social influence based vertex similarity metric in terms of both self-influence similarity and co-influence similarity. We compute self-influence and co-influence based similarity based on social graph and its associated activity graphs and influence graphs respectively. Second, we compute the combined social influence based similarity between each pair of vertices by unifying the self-similarity and multiple co-influence similarity scores through a weight function with an iterative update method. Third, we design an iterative learning algorithm, SI-Cluster, to dynamically refine the K clusters by continuously quantifying and adjusting the weights on self-influence similarity and on multiple co-influence similarity scores towards the clustering convergence. To make SI-Cluster converge fast, we transformed a sophisticated nonlinear fractional programming problem of multiple weights into a straightforward nonlinear parametric programming problem of single variable. Our experiment results show that SI-Cluster not only achieves a better balance between self-influence and co-influence similarities but also scales extremely well for large graph clustering.
Analysis and optimization of force sensitivity in atomic force microscopy using optical and electrical detection (1998)

Atomic force microscopy is a versatile tool for ultrasensitive measurement. We explore the fundamental and practical limits to force sensitivity that are imposed by optical and electrical deflection sensing techniques, and present a method for designing cantilevers to optimize force sensitivity. We calculate the optimized force sensitivity to be 1.2×10−18 N/ Hz at a temperature of 4 K, using a gallium arsenide piezoresistive cantilever with dimensions w=0.1 μm, t=0.1 μm, and L=81 μm, and mechanical quality factor Q=104. The optimized force sensitivities obtained using silicon piezoresistive and optical detection are not far behind.
Modelling of a trellis decoder used as inner code in a concatenated coding system (2002)

Concatenated coding systems can offer very good immunity against noise and can provide noiseless transmission over severely degraded channels. The combination of an inner convolutional code and an outer Reed-Solomon (RS) code has been a popular choice since it offers a good compromise between performance and complexity. Trellis coded modulation (TCM) is a technique that achieves significant coding gains over systems where the code and the modulating scheme has been design independently. Concatenated coding systems based on TCM codes and RS codes have been discussed in the literature. However, in most analysis the bit error rate at the output of the inner decoder is obtained, computed or by computer simulation, and then the performance of the outer decoder is computed using the binomial expression assuming that an interleaver would remove time memory in the error sequence. This paper presents a decoding model for time output of a trellis decoder which allows for a more general analysis of concatenated coding systems where interleaving is not required but can be taken into account if needed. A Markov chain model is used to represent the errors generated by the trellis decoder. The performance of the TCM code can easily be determined from this model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Differential, Dose Dependent Changes in Cognitive Performance Following Acute Administration of a<i>Ginkgo biloba/Panax ginseng</i>Combination to Healthy Young Volunteers (2001)

We have previously shown differential cognitive improvements following single doses of Ginkgo biloba and of Ginseng. There is also evidence that chronic administration of a combination of standardised extracts of Ginkgo biloba and Panax ginseng may improve aspects of cognitive performance both in pathological populations and the healthy middle aged. No investigation has thus far looked either at the cognitive effects of single doses of such a combination, nor the effects of the combination on healthy young volunteers. The present study investigated whether acute administration of a combination of standardised extracts of Ginkgo biloba (GK501, Pharmaton SA) and Ginseng (G115, Pharmaton SA) had any consistent effect on mood and aspects of cognitive performance ("quality of memory", "secondary memory", "working memory", "speed of memory", "quality of attention" and "speed of attention") that can be derived by factor analysis of the cognitive drug research computerised assessment battery. The study followed a placebo-controlled, double blind, balanced, crossover design. Twenty healthy young adult volunteers received 320, 640, and 960 mg of the combination, and a matching placebo, in an order dictated by random allocation to a Latin square, and with a seven-day wash-out period between treatments. Following a baseline cognitive assessment, further test sessions took place 1, 2.5,4 and 6 h after the day's treatment. The most striking result was a dose-dependent improvement in performance on the "quality of memory" factor for the highest dose. Further analysis revealed that this effect was differentially targeted at the secondary memory rather than the working memory component. There was also a dose dependent decrement in performance of the "speed of attention" factor for both the 320 and 640 mg doses. These results are discussed in the context of previous findings within this series of studies.
Influence of particle size of nano zinc oxide on the controlled delivery of Amoxicillin (2012)

A great effort has been exerted to develop drug carriers aiming at satisfying the requirements, such as safety, greater efficiency, predictable therapeutic response, and prolonged release period. The present study aims at developing the use of zinc oxide nanoparticles as a carrier as a function of particle size for amoxicillin drug delivery system. The amoxicillin-loaded zinc oxide nanoparticles have a good antibacterial activity against infectious Gram-positive and Gram-negative bacteria. Zinc oxide nanoparticles have been prepared by wet chemical precipitation method varying the pH values. Particle size and morphology of the as-prepared ZnO powders are characterized by X-ray diffraction, Fourier transform infrared spectroscopy and transmission electron microscope. Drug loading, in vitro drug release and antibacterial activity have been analyzed. Maximum zone of inhibition is observed for Staphylococcus epidermis. The results show that inhibitory efficacy of drug-loaded ZnO nanoparticles is very much dependent on its chosen concentration, drug loading, and size.
Effect of Active Immunization Against Estradiol on Egg Shell Quality (1983)

Seven 31-week-old White Leghorn hens were immunized with estradiol-17-6-(0-carboxymethyl) oxime-bovine serum albumin (.5 to 1 mg/hen; 1- to 7-week intervals for 44 weeks). Six control hens of similar egg shell quality received only bovine serum albumin. Within 35 weeks of immunization, four of the estradiol-17β(E2) antigen-treated birds developed significant titers of antibodies to E2 based on a four- to fivefold increased binding of tritiated labeled E2 to plasma; two hens had low titers (twofold increase), and one had none. Forty-eight weeks after the first injection, the specific gravity (1.0768) and percent shell (8.32) of the four high-titer birds were lower (P<.05) than those of the controls (1.0810 and 8.80, respectively). The six positively immunized hens laid a total of 29 soft-shell eggs out of a total of 1,626 eggs as compared with 7 out of a total of 1,658 eggs laid by the six control birds. No significant increase in plasma binding was observed for the nonphenolic steroid hormones such as progesterone, corticosterone, and testosterone. It was concluded that the effect of immunization on egg shell quality was due to neutralization of estrogen activity.
Über die Elimination der Variabeln aus drei algebraischen Gleichungen vom zweiten Grade mit zwei Variabeln. (1844)

Article Über die Elimination der Variabeln aus drei algebraischen Gleichungen vom zweiten Grade mit zwei Variabeln. was published on January 1, 1844 in the journal Journal für die reine und angewandte Mathematik (volume 1844, issue 28).
The Aluminum Smelting Process and Innovative Alternative Technologies (2014)

Workers' health and safety have now become an integrated part of the aluminum business. Work-related injuries and illnesses are preventable, and the ultimate goal to eliminate accidents with lost-time injuries may hopefully be approached in the future.
İzmir Körfezi Kladoserlerinde Mevsimsel Dağılım. (2006)

İzmir Körfezi kladoserlerinin mevsimsel dağılımlarını saptamak amacıyla 2004-2005 yıllarında bu çalışma gerçekleştirilmiştir. Örnekler, altı istasyondan 200 µm ağ göz açıklığı olan Unesco WP2 tip standart zooplankton kepçesi kullanılarak, dipten yüzeye kadar yapılan vertikal çekimlerle toplanmıştır. Örneklerin değerlendirilmesi sonucunda Penilia avirostris, Evadne spinifera, E. tergestina, E. nordmanni, Podon polyphemoides ve P. intermedius olmak üzere toplam altı kladoser türü tespit edilmiştir. P. avirostris, E. spinifera ve E. tergestina türleri ilkbahar ve özellikle yaz mevsiminde en yüksek bolluk oranlarına ulaşmaları ve yaygın dağılım göstermelerinden dolayı en önemli türlerdir. E. nordmanni yaz mevsimi hariç olmak diğer mevsimlerde, P.intermedius ve P. polyphemoides türleri ise tüm mevsimlerde değişen bolluk oranlarında dağılım göstermektedirler
A matrix converter without diode clamped over-voltage protection (2002)

In this paper, the design and testing of a new protection strategy for a matrix power converter feeding an induction motor is described. The new protection strategy, with excellent overvoltage protection, allows to remove the large and expensive diode clamp.
Supplier Selection Based on Intuitionistic Fuzzy Sets Group Decision Making (2013)

The selection of suppliers had always been a key point of the supply chain management, directly impact the operation of supply chain. In this context, firstly introduced the study situation of supplier selection, established the evaluation index system based on the research and then puts forward a new method for supplier selection based on intuitionistic fuzzy sets. Finally, using an example to illustrate the application of indicators and the method provides a new method for supplier selection.
Regional Availability of Mechanical Embolectomy for Acute Ischemic Stroke in California, 2009 to 2010 (2015)

In California, most patients with stroke lived within reasonable ground transport distances from centers that performed ≥1 mechanical embolectomy in a 2-year period. The probability of receiving mechanical embolectomy for acute ischemic stroke was associated with living in close geographic proximity to these hospitals.
Intermolecular hydrogen bonding in novolacs (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntermolecular hydrogen bonding in novolacsZvonimir Katovic and Miljenko StefanicCite this: Ind. Eng. Chem. Prod. Res. Dev. 1985, 24, 2, 179–185Publication Date (Print):June 1, 1985Publication History Published online1 May 2002Published inissue 1 June 1985https://pubs.acs.org/doi/10.1021/i300018a001https://doi.org/10.1021/i300018a001research-articleACS PublicationsRequest reuse permissionsArticle Views183Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A technique for contacting gases with coarse solid particles (1955)

Abstract Although coarse, uniformly sized particles are not amenable to fluidization, it has been found possible by use of either gases or liquids to impart a regular cycling motion to a bed of this type of material in which the solids are rapidly carried upward by the fluid in a central well‐defined core within the bed. The particles move uniformly downward in the annular space surrounding the core, thus providing dense‐phase countercurrent contact between the fluid and the solids. There is no wall separating the core from the annulus. This method is called the spouted‐bed technique. The effect of column diameter, fluid inlet diameter, bed depth, and physical properties of solids and fluids on spouting behavior has been investigated. The minimum fluid velocity required for spouting has been correlated, and the flow pattern of the fluid and of the solids has been stuided. The technique has been applied to the drying of wheat.
Immunity and the level of neutralization antibodies in foals and mares vaccinated with a modified live-virus rhinopneumonitis vaccine. (1975)

Foals (farms 1 and 2) and mares (farms 1 and 3) vaccinated with a commercially available rhinopneumonitis vaccine were tested for the level of antibodies and for protection against the natural infection. The serum-neutralization (SN) antibody titers against equine herpesvirus type 1 were 1:8 or less in the majority of foals and 1:16 or higher in about 10%. The level of the nasal secretory antibody in the foals (farm 2) was less than 1:4. The vaccinated foals did not show any apparent respiratory tract infection for about 6 months and then an epizootic of respiratory tract disease appeared on farm 1 involving 3 foals. From each of these 3 foals herpesvirus was isolated. On farm 1, about 50% of the vaccinated mares aborted, and on farm 3, there were no abortions. Isolations of herpesvirus were made from 5 of the 6 aborted fetuses (farm 1). The SN antibody titers of the pregnant mares in the 2 farms at the time of foaling were high.
<title>Overview of the space-based laser (SBL) program</title> (2002)

The Space Based Laser (SBL) program is concerned with both near-term feasibility of space lasers and also the desired operational capability for a robust SBL constellation. For the near term system, we have defined an Integrated Flight Experiment (IFX) that will integrate a high power laser device, a beam control system, and a large beam director, performing a lethal engagement against a boosting missile in the 2010-2014 time period. For the operational system, the program was conducted its Affordability and Architecture Study (AAS) for Dr. Jacques Gansler (former USD(AT&L)). We arrived at a particular set of solutions for a prescribed threat. These solutions include both pure SBL constellations and also combinations of SBL satellites and space-based relay mirrors (SBM). We also considered Air Borne Lasers (ABL) and Ground Based lasers (GBL) as complements to the SBL and SBM. In this paper, we describe the current status of both the IFX program, which is the principal recipient of current funding, and also a nascent SBL Technology program to address the needs of the operational system. For the technology program, we analyzed the specific technology areas we need to develop in order to realize the most pay off for operational SBL systems.
Embedding of complete binary trees into meshes with row-column routing (1996)

This paper considers the problem of embedding complete binary trees into meshes using the row-column routing and obtained the following results: a complete binary tree with 2/sup p/-1 nodes can be embedded (1) with link congestion one into a /sup 9///sub 8//spl radic/(2/sup p/)/spl times//sup 9///sub 8//spl radic/(2/sup p/) mesh when p is even and a /spl radic/(/sup 9///sub 8/2/sup p/)/spl times//spl radic/(/sup 9///sub 8/2/sup p/) mesh when p is odd, and (2) with link congestion two into a /spl radic/(2/sup p/)/spl times//spl radic/(2/sup p/) mesh when p is even, and a /spl radic/(2/sup p-1/)/spl times//spl radic/(2/sup p-1/) mesh when p is odd.
Examining Mobile-IP performance in rapidly mobile environments: the case of a commuter train (2002)

Trains travel at speeds ranging from 0 to 80 m/s (0 to 288 km/hr). Providing in-train wireless Internet access to multimedia applications will require the use of a mobile networking protocol, such as Mobile-IP, to achieve uninterrupted connectivity. Although Mobile-IP represents a promising solution. its performance under "extreme" mobility is questionable. We simulated a train scenario and identified the limitations of the current Mobile-IP standard in terms of throughput, handoff and packet loss of a train moving tit different velocities. We investigated the performance of UDP- and TCP-sessions, and examined the effect of different base station interleaving distances on throughput and packet loss. The results presented are part of an investigative research into adaptive mobile networking protocols in rapidly mobile networks.