gebhart/patrepeval huggingface dataset:
Practical design and performance of the stressed-lap polishing tool (1994)

We present an overview of the engineering design and empirical performance of four stressed-lap polishing tools developed at the University of Arizona. Descriptions of the electromechanical actuators, servo systems, computer interfacing, and attachment of the lap to the polishing machine are provided. The empirical performance of a representative tool is discussed in terms of accuracy, repeatability, and hysteresis. Finally, we estimate the statistical likelihood of aluminum lap-plate failure through a metal-fatigue analysis for a worst-case stress-cycling situation.
Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus (2016)

The use of dietary supplements to treat tinnitus is common, particularly with Ginkgo biloba, lipoflavonoids, magnesium, melatonin, vitamin B12, and zinc. It is likely that some supplements will help with sleep for some patients. However, they are generally not effective, and many produced adverse effects. We concluded that dietary supplements should not be recommended to treat tinnitus but could have a positive outcome on tinnitus reactions in some people.
ZCS High Frequency Inverter for Induction Heating with Duplicated Tuned Load Circuit (2001)

We have reported a ZCS high frequency inverter for induction heating uses elsewhere. Its load circuit is composed of a parallel tuned tank load circuit having a heating coil with relatively small inductance, leading to limited applications for the inverter. This paper presents a duplicated tuned load circuit to deal with a tank load having a heating coil with a higher inductance, to widen application range of the inverter. It is found that the high frequency inverter having the improved tank load circuit reveals a high efficiency reaching 89 percent. Its circuit operation and performance are analyzed on the basis of computer-aided simulation and its actual behaviors are examined from a practical point of view for a feasible breadboard.
24—INCREASING THE RATES OF FABRIC PRODUCTION OF WEFT-KNITTING MACHINERY: PART II: AN ANALYSIS OF HIGH-SPEED KNITTING-CAM SYSTEMS (1970)

It has been shown in the preceding paper how high-speed cam systems were desired to give substantial increases in the rate of fabric production of weft-knitting machinery. This paper provides a detailed analysis of the effect of cam shape on the knitting-yarn tensions, machine performance, and individual needle forces. It is explained that, although the yarn tensions developed within the knitting cycle are greater for high-speed cams than for conventional linear cams, these tensions do not affect the resulting fabric appearance or the machine performance. In addition, calculations of individual needle forces and high-speed trials indicate that speeds many times as great as commercial speeds may be achieved with the mathematically designed high-speed cams.
rNAPc2 Inhibits Colorectal Cancer in Mice through Tissue Factor (2008)

rNAPc2 is a potent anticancer agent when used in combination with chemotherapy or antiangiogenic therapy in mouse models of colorectal cancer, and TF positivity appears to be required for its activity.
Cross-layer performance analysis of joint rate and power adaptation schemes with multiple-user contention in Nakagami fading channels (2006)

Adaptively adjusting transmission rate and power to concurrently enhance goodput and save energy is an important issue in the wireless local area network (WLAN). However, goodput enhancement and energy saving are two contradictory goals, since high data rate usually requires high transmission power to meet the bit-error-rate (BER) requirement. To achieve the tradeoff between energy efficiency and goodput, therefore, we suggest a fast channel-driven rate and power adaptation (CDRPA) algorithm. Furthermore, we develop a physical (PHY)/medium access control (MAC) cross-layer analytical method to evaluate goodput and energy efficiency, incorporating the impacts of Nakagami fading channel and the carrier sense multiple access (CSMA) MAC protocol. This paper compares two adaptation schemes. The power-first scheme first selects the transmission power and then the data rate, aiming at energy saving. On the contrary, the rate-first scheme first selects the data rate and then the transmission power, aiming to enhance goodput. Numerical results show that the power-first scheme achieves better energy efficiency. However, the rate-first CDRPA scheme can indeed boost goodput, while maintaining comparable energy efficiency as the power-first scheme.
Photocatalytic hydrogen generation from a visible-light responsive metal–organic framework system: the impact of nickel phosphide nanoparticles (2018)

We showcase the key role of the co-catalyst when combined with MIL-125-NH<sub>2</sub> towards the photocatalytic H<sub>2</sub> generation.
Serendipitous Discovery of a Cascade Approach to Perhydrodibenzofuranones Related to the Natural Product Incarviditone (2014)

The unexpected discovery of an eliminative deprotection and cyclodimerization cascade reaction sequence led to the preparation of a series of perhydrodibenzofuranones that bear a structural resemblance to the natural product incarviditone. One of the novel dimers was found to show significant antiproliferative activity towards a non-small-cell lung cancer cell line, and represents a useful lead compound for the discovery of more potent anti-cancer agents.
Robust Fixed-Order Controller Design for Uncertain Systems with Generalized Common Lyapunov Strictly Positive Realness Characterization (2020)

This paper investigates the design of a robust fixed-order controller for single-input-single-output (SISO) polytopic systems with interval uncertainties, with the aim that the closed-loop stability is appropriately ensured and the performance specifications on sensitivity shaping are conformed in a specific finite frequency range. Utilizing the notion of generalized common Lyapunov strictly positive realness (CL-SPRness), the equivalence between strictly positive realness (SPRness) and strictly bounded realness (SBRness) is established; and then the specifications on robust stability and performance are transformed into the SPRness of newly constructed systems and further characterized in the framework of linear matrix inequality (LMI) conditions. The proposed methodology avoids the tedious yet mandatory evaluations of the specifications on all vertices of the uncertain polytopic system in an explicit form. Instead, solving five LMIs exclusively suffices for ensuring the robust stability and performance regardless of the number of vertices, and thus the typically heavy computational burden is considerably alleviated. It is also noteworthy that the proposed methodology additionally provides the necessary and sufficient conditions for this robust controller design with the consideration of a prescribed finite frequency range, and therefore significantly less conservatism is attained in the system performance.
Alkaliempfindliche Glucoside: Das Glucosid des Äthylencyanhydrins (1949)

Das β-d-Glucosid des Äthylencyanhydrins, das neu hergestellt wird, erweist sich als alkaliempfindlich. Das aus ihm gewonnene β-d-Glucosid des Aminoäthanols verhält sich normal.
Noval Insights into the Role of Platelet Angiogenic Growth Factors on the Regulation of Normal Vascular Development (2017)

Abstract The role of platelets as angiogenic regulators has been the subject of intense research over the last decade, and has led to the recognition of platelets as the predominant source of key angiogenic growth factors (AGFs) in the circulation. Through the regulated delivery of these factors, platelets contribute to wound healing, maintenance of vascular integrity, and tumor angiogenesis. Prior studies have shown that thrombocytopenia in adult mice leads to hemorrhages primarily from structurally abnormal new blood vessels, both in in vivo angiogenesis assays and inside tumors. The rapid growth during fetal and neonatal life is associated with a developmental stage-specific need for accelerated angiogenesis and vascular development. However, whether and how platelets participate in normal fetal/neonatal vascular development is unknown, except for their role in blood/lymphatic separation. We hypothesized that platelets would be important for normal fetal/neonatal vascular development, and that their AGF profile would be different from that of adult platelets. As a first step, we quantified five key AGFs (VEGF-A, bFGF, ANG-1, PDGF-BB and TGF-b) by ELISA in platelet lysates and platelet-poor plasma from term cord blood samples (CB; n=12) and from the peripheral blood of healthy adult volunteers (PB; n=8). These studies demonstrated that CB platelets, just like PB platelets, are the major source of AGFs in the circulation, carrying more than 80% of the levels of these AGFs present in the blood. However, the angiogenic profiles were different in platelets of different developmental origins. Fetal/neonatal platelets contained ~70% more bFGF and VEGF-A than adult platelets (p Disclosures Sola-Visner: Sysmex Inc.: Research Funding.
Calixarenartige Makrocyclen durch Oxidation phenolischer Vitamin-E-Derivate (2002)

Sicher nicht so gesund wie Vitamin E ist das α-Tocopherol-Derivat 1, dessen Struktur einem „Siamesischen Zwillingspaar“ entspricht. Dafür lassen sich aber alle wichtigen Reaktionen von α-Tocopherol mit 1 gleich zweimal durchführen. Die Umsetzung von 1 in einer dreistufigen Reaktionsfolge aus Oxidation, Hetero-Diels-Alder-Reaktion und Reduktion eröffnet zudem einen Zugang zu neuartigen calixarenartigen Makrocyclen wie 2.
Comparison of Be and C diffusion in heavily doped polycrystalline GaAs (1994)

The diffusion of Be and C in heavily doped polycrystalline GaAs grown by molecular beam epitaxy and metalorganic chemical vapor deposition has been studied by secondary-ion mass spectrometry and Hall measurement. It is found that Be rapidly diffuses into the undoped buffer layer at a growth temperature of 450 °C. Concentration-depth profiles of Be in AlGaAs/GaAs heterojunction bipolar transistor layers indicate that Be diffuses mainly along polycrystal grain boundaries. On the other hand, C diffusion is negligible even for post-growth annealing at 800 °C. However, annealing increases the resistivity of C-doped GaAs, which is probably due to a change in the occupation site preference of C atoms from As sites.
Improved heterologous protein expression in the chloroplast of <i>Chlamydomonas reinhardtii</i> through promoter and 5′ untranslated region optimization (2011)

Summary Microalgae have the potential to be a valuable biotechnological platform for the production of recombinant proteins. However, because of the complex regulatory network that tightly controls chloroplast gene expression, heterologous protein accumulation in a wild‐type, photosynthetic‐competent algal chloroplast remains low. High levels of heterologous protein accumulation have been achieved using the psbA promoter/5′ untranslated region (UTR), but only in a psbA ‐deficient genetic background, because of psbA/D1‐dependent auto‐attenuation. Here, we examine the effect of fusing the strong 16S rRNA promoter to the 5′ UTR of the psbA and atpA genes on transgene expression in the chloroplast of Chlamydomonas reinhardtii . We show that fusion of the 16S promoter had little impact on protein accumulation from the psbA 5′ UTR in a psbA ‐deficient genetic background. Furthermore, the 16S/psbA promoter/UTR fusion was silenced in the presence of wild‐type levels of D1 protein, confirming that the psbA 5′ UTR is the primary target for D1‐dependent auto‐repression. However, fusion of the 16S promoter to the atpA 5′ UTR significantly boosts mRNA levels and supports high levels of heterologous protein accumulation in photosynthetic‐competent cells. The 16S/atpA promoter/UTR drove LUXCT protein accumulation to levels close to that of psbA in a psbA− background, and drove expression of a human therapeutic protein to levels only twofold lower than the psbA 5′ UTR. The 16S/atpA promoter/UTR combination should have utility for heterologous protein production when expression from a photosynthetic‐competent microalgal strain is required.
Eucoilinae of North America: A Revised Catalog of Genera and Described Species (2013)

We present an updated catalog of North American Eucoilinae, bearing little resemblance to previous regional catalogs, which have been lagging behind in the recent systematic work in the group. The current catalog comprises 34 genera, arranged in six tribes. Of these genera, 9 are represented wholly by unidentified or undescribed species in the region, while the other 25 include 108 species recorded from the region. In comparison with previous catalogs, 24 genera and 41 species are added, and 34 species-level names are recombined, while 7 genera, five subgenera and 11 species are removed from the list of North American taxa. A modern, phylogenetically stable and type-based classification is implemented, as well as a tribal classification. In terms of nomenclatural acts, 25 new combinations are made (one is a reinstatement of an old combination); four new genus-levels synonymies are made (Tetramerocera Ashmead junior synonym of Ganaspis Förster, Bewelda Quinlan and Aporeucoela Kieffer junior synonyms of Hexacola Förster, Pentaplastidia Weld junior synonym of Trybligrapha Förster); eight new species-level synonymies are made; two species names are removed from synonymy; one new replacement name given (Hexacola pennsylvanicus for Hexacola subaperta Kieffer 1907 nec (Kieffer 1901a)).
IP-Telefonie über Differentiated Services (2001)

ZUSAMMENFASSUNG Neben klassischen Datendiensten sollen Echtzeitdienste im Internet bereitgestellt werden. Insbesondere hat in diesem Zusammenhang die IP-Telefonie in den letzten Jahren an Bedeutung gewonnen. Es fehlt aber immer noch eine geeignete Infrastruktur, um Echtzeitanwendungen die geforderte Dienstgüte garantieren zu können. Der zur Zeit bei der IETF entwickelte Ansatz der Differentiated Services wird in dieser Arbeit bezüglich seiner Eignung für IP-Telefonie untersucht.
The Advanced Software Development and Commercialization Project (1990)

This is the first of a series of reports pertaining to progress in the Advanced Software Development and Commercialization Project, a joint collaborative effort between the Center for Supercomputing Research and Development of the University of Illinois and the Computing and Telecommunications Division of Argonne National Laboratory. The purpose of this work is to apply techniques of parallel computing that were pioneered by University of Illinois researchers to mature computational fluid dynamics (CFD) and structural dynamics (SD) computer codes developed at Argonne. The collaboration in this project will bring this unique combination of expertise to bear, for the first time, on industrially important problems. By so doing, it will expose the strengths and weaknesses of existing techniques for parallelizing programs and will identify those problems that need to be solved in order to enable wide spread production use of parallel computers. Secondly, the increased efficiency of the CFD and SD codes themselves will enable the simulation of larger, more accurate engineering models that involve fluid and structural dynamics. In order to realize the above two goals, we are considering two production codes that have been developed at ANL and are widely used by both industry and Universities. These are COMMIX and WHAMS-3D. The first is a computational fluid dynamics code that is used for both nuclear reactor design and safety and as a design tool for the casting industry. The second is a three-dimensional structural dynamics code used in nuclear reactor safety as well as crashworthiness studies. These codes are currently available for both sequential and vector computers only. Our main goal is to port and optimize these two codes on shared memory multiprocessors. In so doing, we shall establish a process that can be followed in optimizing other sequential or vector engineering codes for parallel processors.
The Endothelial Cell and the Factor VIII Bypassing Activity of Prothrombin Complex Concentrate (1988)

Some classical hemophiliacs have a paradoxical hemostatic response to prothrombin complex concentrate (PCC). We hypothesized that vascular endothelial cells (EC) may contribute to this "factor VIII bypassing activity". When PCC were incubated with suspensions or monolayer cultures of EC, they acquired the ability to partially bypass the defect of factor VIII deficient plasma. This factor VIII bypassing activity distributed with EC and not with the supernatant PCC, and was not a general property of intravascular cells. The effect of PCC was even more dramatic on fixed EC monolayers, which became procoagulant after incubation with PCC. The time courses of association and dissociation of the PCC-derived factor VIII bypassing activity of fixed and viable EC monolayers were both rapid. We conclude that EC may provide a privileged site for sequestration of constituents of PCC which express coagulant activity and which bypass the abnormality of factor VIII deficient plasma.
Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice (2014)

Nitric oxide (NO) is synthesized by three distinct NO synthases (neuronal, inducible, and endothelial NOSs), all of which are expressed in almost all tissues and organs in humans. The regulatory roles of NOSs in vivo have been investigated in pharmacological studies with non-selective NOS inhibitors. However, the specificity of the inhibitors continues to be an issue of debate, and the authentic significance of NOSs is still poorly understood. To address this issue, we generated mice in which all three NOS genes are completely disrupted. The triple NOSs null mice exhibited cardiovascular abnormalities, including hypertension, arteriosclerosis, myocardial infarction, cardiac hypertrophy, diastolic heart failure, and reduced EDHF responses, with a shorter survival. The triple NOSs null mice also displayed metabolic abnormalities, including metabolic syndrome and high-fat diet-induced severe dyslipidemia. Furthermore, the triple NOSs null mice showed renal abnormalities (nephrogenic diabetes insipidus and pathological renal remodeling), lung abnormalities (accelerated pulmonary fibrosis), and bone abnormalities (increased bone mineral density and bone turnover). These results provide evidence that NOSs play pivotal roles in the pathogenesis of a wide variety of disorders. This review summarizes the latest knowledge on the significance of NOSs in vivo, based on lessons learned from experiments with our triple mutant model.
A simple route to bimodal mesoporous silica via tetrafluoroborate ion-mediated hydrophobic transformation of template micellar surface (2005)

Addition of NaBF4 to an aqueous solution of an onium ion surfactant results in the in situ generation of large aggregates of micelles, which template the formation of secondary pores in the sol-gel synthesis of mesoporous silica.
Protein Phosphatase-Mediated Regulation of Protein Kinase C during Long-Term Depression in the Adult Hippocampus<i>In Vivo</i> (2000)

The neural substrates of learning and memory are thought to involve use-dependent long-term changes in synaptic function, including long-term depression (LTD) of synaptic strength. One biochemical event hypothesized to contribute to the maintenance and expression of LTD is decreased protein phosphorylation, caused by a decrease in protein kinase activity and/or an increase in protein phosphatase activity. We tested whether the activity of protein kinase C (PKC) decreases after the induction of LTD in area CA1 of the adult hippocampus in vivo, and then investigated the mechanism responsible for the LTD-associated alteration in PKC activity. We found that LTD was associated with a significant decrease in both autonomous and cofactor-dependent PKC activity. The decrease in PKC activity was prevented by NMDA receptor blockade and was not accompanied by a decrease in the level of either PKCalpha, beta, gamma, or zeta. Western blot analysis with phosphospecific antibodies revealed that phosphorylation of Ser-657 on the catalytic domain of PKCalpha (Ser-660 on PKCbetaII) was decreased significantly after the induction of LTD, and that this dephosphorylation was prevented by the protein phosphatase inhibitor okadaic acid. The decrease in autonomous and cofactor-dependent PKC activity likewise was prevented by okadaic acid. These findings suggest that LTD in the adult hippocampus in vivo involves a decrease in PKC activity that is mediated, at least in part, by dephosphorylation of the catalytic domain of PKC by protein phosphatases activated after LTD-inducing stimulation. Our findings are consistent with the idea that protein dephosphorylation contributes to the expression of LTD.
Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application (2012)

A sensor designed to detect bio-molecules is presented. The sensor exploits a planar 2D photonic crystal (PC) membrane with sub-micron thickness and through holes, to induce high optical fields that allow detection of nano-particles smaller than the diffraction limit of an optical microscope. We report on our design and fabrication of a PC membrane with a nano-particle trapped inside. We have also designed and built an imaging system where an optical microscope and a CCD camera are used to take images of the PC membrane. Results show how the trapped nano-particle appears as a bright spot in the image. In a first experimental realization of the imaging system, single particles with a radius of 75 nm can be detected.
Cell Nuclei Spin in the Absence of Lamin B1 (2007)

Mutations of the nuclear lamins cause a wide range of human diseases, including Emery-Dreifuss muscular dystrophy and Hutchinson-Gilford progeria syndrome. Defects in A-type lamins reduce nuclear structural integrity and affect transcriptional regulation, but few data exist on the biological role of B-type lamins. To assess the functional importance of lamin B1, we examined nuclear dynamics in fibroblasts from Lmnb1(Delta/Delta) and wild-type littermate embryos by time-lapse videomicroscopy. Here, we report that Lmnb1(Delta/Delta) cells displayed striking nuclear rotation, with approximately 90% of Lmnb1(Delta/Delta) nuclei rotating at least 90 degrees during an 8-h period. The rotation involved the nuclear interior as well as the nuclear envelope. The rotation of nuclei required an intact cytoskeletal network and was eliminated by expressing lamin B1 in cells. Nuclear rotation could also be abolished by expressing larger nesprin isoforms with long spectrin repeats. These findings demonstrate that lamin B1 serves a fundamental role within the nuclear envelope: anchoring the nucleus to the cytoskeleton.