gebhart/patrepeval huggingface dataset:
Autologous and Allogeneic Equine Mesenchymal Stem Cells Exhibit Equivalent Immunomodulatory Properties In Vitro (2016)

The use of allogeneic bone marrow-derived mesenchymal stem cells (BMDMSCs) may provide an effective alternative to autologous BMDMSCs for treatment of equine musculoskeletal injuries. However, concerns have been raised regarding the potential safety and effectiveness of allogeneic BMDMSCs. We conducted studies to assess the immunological properties of equine allogeneic BMDMSCs compared with those of autologous BMDMSCs. For assessment of inherent immunogenicity, the relative ability of allogeneic and autologous BMDMSCs to stimulate spontaneous proliferation of equine lymphocytes was compared. The immunosuppressive activity of the two cell types was evaluated by adding autologous or allogeneic BMDMSCs to activated lymphocytes and assessing suppression of lymphocyte proliferation and IFNγ production. Fifty-six allogeneic and 12 autologous combinations were evaluated. Studies were also done to elucidate mechanisms by which equine mesenchymal stem cells (MSCs) suppress lymphocyte function. Potential mechanisms evaluated included production of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), nitric oxide, transforming growth factor-beta, and indoleamine 2,3-dioxygenase. We found that autologous and allogeneic BMDMSCs both induced mild but equivalent levels of spontaneous lymphocyte activation in vitro. In in vitro assays assessing the ability of BMDMSCs to suppress activated lymphocytes, both allogeneic and autologous BMDMSCs suppressed T cell proliferation and IFNγ production to an equal degree. The primary mechanism of equine BMDMSC suppression of T cells was mediated by PGE<sub>2</sub>. We concluded that allogeneic and autologous BMDMSCs are equivalent in terms of their immunomodulatory properties, and stimulated peripheral blood mononuclear cells appear to trigger the immunosuppressive properties of MSCs. Therefore, both cell types appear to have equal potency in modulating inflammatory processes related to acute or chronic musculoskeletal injuries in the horse.
Mechanisms for safely abandoning loop-free convergence (AAH) (2008)

IPFRR and loop-free convergence techniques can deal with single
topology change events, multiple correlated change events, and in some
cases even certain uncorrelated events. However, in all cases there
are events which cannot be dealt with and the mechanism needs to
quickly revert to normal convergence. This is known as Abandoning All
Hope (AAH). This document describes the nature of the problem, and
various proposed mechanisms to deal with it.
Patients with adult minimal change nephrotic syndrome treated with long-term cyclosporine did not experience a reduction in their eGFR (2012)

At our institution, patients who were treated for MCNS with CyA for at least 2 years experienced no deterioration in renal function.
Towards a Piecewise-Homogeneous Metamaterial Model of the Collision of Two Linearly Polarized Gravitational Plane Waves (2014)

We considered the experimental realization of a Tamm medium that is optically equivalent to the collision of two linearly polarized gravitational plane waves as a piecewise-homogeneous metamaterial. Our formulation was based on the homogenization of remarkably simple arrangements of oriented ellipsoidal nanoparticles of isotropic dielectric-magnetic mediums. The inverse Bruggeman homogenization was used to estimate the constitutive parameters, volume fractions, and shape parameters for the component mediums. The presented formulation is appropriate for the regions of spacetime where the two gravitational plane waves interact, excluding the immediate vicinity of the nonsingular Killing-Cauchy horizon at the focusing point of the two plane waves.
Pain Management After Outpatient Shoulder Arthroscopy: A Systematic Review of Randomized Controlled Trials (2016)

On the basis of the evidence in this review, we recommend the use of ISBs as the most effective analgesic for outpatient arthroscopic shoulder surgery.
Long-Term Interest Rates and Consol Bond Valuation (2011)

The literature in the area of interest rate modelling is extensive. Traditional term structure models, such as Vasicek (1977) and Cox et al (1985) specify the short rate process. As short-term and long-term rates are not perfectly correlated, the data are clearly inconsistent with the use of one-factor time-homogeneous models. Chan et al (1992) demonstrate the empirical difficulties of one-factor continuous-time specifications within the Vasicek and Cox-Ingersoll-Ross (CIR) class of models using the generalized methods of moments.
Method for recoating phosphor on commercial low-energy electron diffraction optics (1992)

We describe a method for applying a new coat of phosphor to a commercial low-energy electron diffraction screen. The method is based on sedimentation of a phosphor suspension onto the screen.
The polarity of the cauliflower mosaic virus genome (1979)

We have demonstrated that the 5' termini of the DNAs of cauliflower mosaic virus (CaMV) isolates CM4-184 and Cabb B-JI have free hydroxyl groups accessible for phosphorylation using polynucleotide kinase. This has enabled us, using the Cabb B-JI isolate, to label and identify the 5' nucleotides. Digestion of 5' terminally labelled DNA with EcoRI restriction endonuclease revealed that only three of the eleven single-stranded EcoRI fragments were labelled, those situated adjacent to the three known gaps in the double-stranded genome. Identification of the labelled fragments indicated the polarity of the genome. Hybridization experiments using RNA transcripts from infected leaves gave results consistent with the polarity data and confirmed the direction of transcription. Transcription on the largest DNA strand (alpha strand) is initiated between map units 0.24 and 0.30 and terminates between map units 0.0 and 0.24.
Optical bistability in one-dimensional magnetic photonic crystal with two defect layers (2008)

One-dimensional magnetic photonic crystal with two magnetic defect layers is theoretically studied. The dependence of defect modes inside photonic band gap on the distance between defect layers is investigated. It is shown that the cubic nonlinear polarization leads to the effect of bistability on the frequencies of defect modes.
Visual Outcomes and Astigmatism After Sutureless, Manual Cataract Extraction in Rural China (2007)

These results confirm the effectiveness of skill transfer in this setting, with superior outcomes to most studies in rural Asia and to eyes in this cohort operated on at other facilities.
Ein SN‐Ring mit Schwefelatomen der Koordinationszahlen 2, 3 und 4 durch nucleophile Substitution (1979)

Nucleophile Substitutionsreaktionen bei Schwefel‐Stickstoff‐Verbindungen waren bisher unbewiesen. Jetzt wurde aus ( 1 ) und NaOCH 3 quantitativ das überraschend stabile Salz ( 2 ) gewonnen, dessen Anion S‐Atome mit drei unterschiedlichen Koordinationszahlen enthält. magnified image
Reagent contamination can critically impact sequence-based microbiome analyses (2014)

Abstract The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metagenomics. One potential confounder of these sequence-based approaches is the presence of contamination in DNA extraction kits and other laboratory reagents. In this study we demonstrate that contaminating DNA is ubiquitous in commonly used DNA extraction kits, varies greatly in composition between different kits and kit batches, and that this contamination critically impacts results obtained from samples containing a low microbial biomass. Contamination impacts both PCR based 16S rRNA gene surveys and shotgun metagenomics. These results suggest that caution should be advised when applying sequence-based techniques to the study of microbiota present in low biomass environments. We provide an extensive list of potential contaminating genera, and guidelines on how to mitigate the effects of contamination. Concurrent sequencing of negative control samples is strongly advised.
A Computational Investigation of Bio-Inspired Formation Flight and Ground Effect (2007)

Energy saving strategies such as formation flight and near-ground flight are frequently exploited in nature. The energy reduction mechanisms of these approaches are conceptually simple; however, the unsteady wake vortex structures that result from flapping may provide additional benefits. Since these flight strategies oer increased energy savings over simple flight situations, they have received much attention from both the biological sciences and engineering research communities; however, these analysis have traditionally been restricted to the steady aerodynamics of rigid wing vehicles. In this paper, we present a preliminary computational study of energy saving strategies in flapping flight. In both formation flight and ground eect flight, beneficial energy savings are predicted. In the case of formation flight, optimal savings are predicted to occur when the unsteady wake vorticity is exploited by ensuring that the two flappers’ wakes are in spatial phase with wingtips slightly overlapping.
USING PROTEIN-PROTEIN INTERACTIONS FOR REFINING GENE NETWORKS ESTIMATED FROM MICROARRAY DATA BY BAYESIAN NETWORKS (2003)

We propose a statistical method to estimate gene networks from DNA microarray data and protein-protein interactions. Because physical interactions between proteins or multiprotein complexes are likely to regulate biological processes, using only mRNA expression data is not sufficient for estimating a gene network accurately. Our method adds knowledge about protein-protein interactions to the estimation method of gene networks under a Bayesian statistical framework. In the estimated gene network, a protein complex is modeled as a virtual node based on principal component analysis. We show the effectiveness of the proposed method through the analysis of Saccharomyces cerevisiae cell cycle data. The proposed method improves the accuracy of the estimated gene networks, and successfully identifies some biological facts.
X-ray absorption spectroscopy of bacterial sulfur globules (2002)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Interferon-γ is essential for the development of cerebral malaria (Vol. 27(4) 1997, pp 810-815) (1998)

The authors wish to retract the present form of this publication since serious, inadvertent errors occurred in the compilation of the text and figures, part of which (Figs. 2B, 3, 5) were used in the publication ‘Resistance to cerebral malaria in TNF αβ-deficient mice is associated with a reducton of intercellular adhesion molecule-1 up-regulation and T helper type 1 response’ by Rudin et al., Am. J. Pathol. 1997, 150: 257. We apologize for the errors, but wish to state that the conclusions drawn from the experiments with Plasmodium berghei in IFN-γR-deficient mice are correct.
Nature of the Interaction of Olefin-Bromine Complexes. Inference from (E)-2,2,5,5-Tetramethyl-3,4-diphenylhex-3-ene, the First Example of an Olefin Whose Reaction with Bromine Stops at the Stage of .pi. Complex Formation (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNature of the Interaction of Olefin-Bromine Complexes. Inference from (E)-2,2,5,5-Tetramethyl-3,4-diphenylhex-3-ene, the First Example of an Olefin Whose Reaction with Bromine Stops at the Stage of .pi. Complex FormationGiuseppe Bellucci, Cinzia Chiappe, Roberto Bianchini, Dieter Lenoir, and Rainer HergesCite this: J. Am. Chem. Soc. 1995, 117, 48, 12001–12002Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ja00153a025https://doi.org/10.1021/ja00153a025research-articleACS PublicationsRequest reuse permissionsArticle Views245Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ultrasonography in acute interstitial laser irradiation of the pig brain: Preliminary results (1995)

In this preliminary study, the use of real-time ultrasonography to visualize the effects of acute interstitial Nd:YAG laser irradiation was investigated in the normal pig brain. In six pigs, a craniotomy was performed. In the frontal or temporal lobe, a thermal laser lesion was made using a 600-μm-diameter optical fiber at powers of 1 W, 2 W, and 4 W with exposure times of 5 min and 10 min. Ten to thirty minutes after laser irradiation, the pigs were sacrificed. Ultrasound imaging was performed before, during, and after laser irradiation. During laser irradiation, a clear hyperechogenic area was observed around the fiber tip. The onset of the changes and the extent of the lesion were dependent on the power and exposure time. Histologic examination showed thermal lesions consisting of coagulation necrosis and edema. The size of the lesions correlated well with size on ultrasound imaging. The maximal lesion dimension was 12 mm in diameter (4 W for 5 min). In conclusion, within the limitations of this experimental setup, it is feasible to visualize interstitial laser-induced lesions in the brain by ultrasonography. This method is safe and simple and may be helpful in future applications of interstitial thermotherapy in brain tissue. J Image Guid Surg 1:237–241 (1995). © 1996 Wiley-Liss, Inc.
Development of a Computational Framework to Model the Scale-up of High-Solid-Content Polymer Latex Reactors (2010)

International audience
[Behavior of patients with mild-to-moderate arterial hypertension in relation to their treatment. Contribution of an electronic pillbox]. (1995)

The objective of the MACH1 study (MEMS for the Assessment of Compliance of Hypertensives) was to evaluate the real behaviour of patients in relation to antihypertensive treatment administered as a single daily dose. After a 2-week period during which no other antihypertensive was allowed to be administered, 590 patients with mild-to-moderate hypertension received 2 mg of trandolapril as a single daily dose in the morning between 7:00 a.m. and 9:00 a.m. for 4 weeks. Treatment was packaged in electronic pillboxes recording the date and time of each opening. Various profiles were distinguished on the basis of the individual chronograms for the 501 patients able to be analysed in terms of compliance, and as a function of the deviations observed in relation to the treatment regimen prescribed. One hundred and two patients (20%) omitted more than 20% of the prescribed doses, either consecutive doses or scattered throughout the month of treatment; these patients were referred to as "omitters". The other patients were classified according to the scatter of openings in relation to the mean time of the dose: 10 "metronome" patients (2%), 126 "regular" patients (25%), 221 "irregular" patients (44%) and 42 "anarchic" patients (8%). Irregularities of dose times were more frequent on public holidays than on week days and in patients living in Paris or the Paris region. "Metronome" patients were older than the overall patient population. The use of an electronic pillbox could allow the attending physician to more adequately adapt his therapeutic approach and management of specific problems of compliance observed in hypertensive patients.
Conformational and configurational equilibria of the eight D-aldopentopyranose tetra-acetates (1969)

P. L. Durette and D. Horton, J. Chem. Soc. D, 1969, 516 DOI: 10.1039/C29690000516
Vector prefetching (1995)

This paper focuses on extending the memory subsystem by integrating a prefetch buffer mechanism. Prefetching allows high-level application knowledge to increase memory performance, which is currently constraining the performance of most system. While prefetching does not reduce the latency of memory accesses, it hides this latency by overlapping memory access and instruction execution. The first prefetch operation to the buffer is initiated by an explicit fetch instruction. All further prefetch operations are issued automatically whenever a prefetched value is consumed. To efficiently support list and vector processing, the user can specify a stride value at the time the first prefetch operation is initiated.
Blind quality assessment of JPEG2000 compressed images using natural scene statistics (2004)

Measurement of image quality is crucial for many image-processing algorithms, such as acquisition, compression, restoration, enhancement and reproduction. Traditionally, researchers in image quality assessment have focused on equating image quality with similarity to a 'reference' or 'perfect' image. The field of blind, or no-reference, quality assessment, in which image quality is predicted without the reference image, has been largely unexplored. In this paper, we present a blind quality assessment algorithm for images compressed by JPEG2000 using natural scene statistics (NSS) modelling. We show how reasonably comprehensive NSS models can help us in making blind, but accurate, predictions of quality. Our algorithm performs close to the limit imposed on useful prediction by the variability between human subjects.
Light outcoupling effect in GaN light-emitting diodes via convex microstructures monolithically fabricated on sapphire substrate (2011)

GaN-based light-emitting diode (LED) was fabricated on the sapphire substrate with monolithic convex microstructures (CMs) array. Using confocal scanning electroluminescence (EL), we have directly observed the strong outcoupling phenomenon of the light confined in a LED via the CMs array. This outcoupled light could be efficiently converged on the convex center through consecutive reflections at the flat area and the curved slant area of the CMs array. Compared to the conventional LED, the ray tracing simulation and far field EL results of the LED with a CM array showed efficient light extraction toward the top surface, i.e., 0-5, 40-45 and 60-65 degree by the outcoupling effect. We conclude that the outcoupled optical path via CMs is the dominant factor of the enhanced light extraction in the LED with a CM array.
Cotranslocation of Methyl Parathion Hydrolase to the Periplasm and of Organophosphorus Hydrolase to the Cell Surface of <i>Escherichia coli</i> by the Tat Pathway and Ice Nucleation Protein Display System (2009)

A genetically engineered Escherichia coli strain coexpressing organophosphorus hydrolase (OPH) and methyl parathion hydrolase (MPH) was constructed for the first time by cotransforming two compatible plasmids. Since these two enzymes have different substrate specificities, the coexpression strain showed a broader substrate range than strains expressing either one of the hydrolases. To reduce the mass transport limitation of organophosphates (OPs) across the cell membrane, MPH and OPH were simultaneously translocated to the periplasm and cell surface of E. coli, respectively, by employing the twin-arginine translocation (Tat) pathway and ice nucleation protein (INP) display system. The resulting recombinant strain showed sixfold-higher whole-cell activity than the control strain expressing cytosolic OP hydrolases. The correct localization of MPH and OPH was demonstrated by cell fractionation, immunoblotting, and enzyme activity assays. No growth inhibition was observed for the recombinant E. coli strain, and suspended cultures retained almost 100% of the activity over a period of 2 weeks. Owing to its high level of activity and superior stability, the recombinant E. coli strain could be employed as a whole-cell biocatalyst for detoxification of OPs. This strategy of utilizing dual translocation pathways should open up new avenues for cotranslocating multiple functional moieties to different extracytosolic compartments of a bacterial cell.
FcR epsilon+ lymphocytes and regulation of the IgE antibody system. V. Preliminary physicochemical characterization of the T cell-selective IgE-induced regulant EIRT. (1986)

We previously showed that murine lymphoid cells exposed to elevated levels of IgE exhibit the de novo expression of Fc receptors for IgE (FcR epsilon), and the production of soluble mediators, which we have termed IgE-induced regulants (EIR). Described herein is the preliminary physicochemical characterization of one such regulant, that being the EIR responsible for the Lyt-2+ T cell-dependent expression of FcR epsilon and secretion of an IgE-binding factor (IgE-BF) which can potentiate IgE synthesis; the former activity has been denoted EIRT for its selectivity of action on T cells, and the latter activity has been termed enhancing effector molecule (EEM) for its presumed potentiating influence on IgE antibody synthesis. Characterized in parallel was the conventional lymphoid cell-derived cEIRT and a murine monoclonal T cell hybridoma-(MBI-2)-derived mcEIRT. EIRT from either source was shown to exhibit the characteristics of a protein with a molecular mass of 45 to 60 kd. Once enriched by gel filtration, neither cEIRT nor mcEIRT preparations displayed any other EIR-like activity except that of EIRT, as evidenced by the ability of these preparations to act selectively to induce the Lyt-2 T cell-dependent expression of FcR epsilon and the production of EEM, the lack of detectable SFA activity that could induce Lyt-1+ T cells to produce the IgE-BF denoted suppressive effector molecule (SEM), and the lack of detectable levels of the B cell-selective EIRB, as indicated by the incapacity of either preparation to induce B cell FcR epsilon expression. Neither cEIRT nor mcEIRT displayed IgE-binding affinity, in contrast to the EEM produced in response to stimulation with these regulants. The only EIR-like activity detected in the unfractionated supernatant fluid from cultures of the monoclonal T cell hybridoma MBI-2 was that of EIRT. Careful in vitro analysis established that such preparations did not contain enhancing factor of allergy (EFA), SFA, EIRB, or IgE-BF. Thus, the enhancement of IgE synthesis observed in animals given this mcEIRT preparation was most likely due to the activity of EIRT known to be present. During the course of these studies, clues as to the physicochemical nature of other EIR activities was obtained. Thus, upon molecular sieve analysis, two distinct molecular mass species of EIRB (one 15 to 20 kd and the other 30 to 35 kd) were demonstrated to be present in conventional lymphocyte-derived cEIR.(ABSTRACT TRUNCATED AT 400 WORDS)