gebhart/patrepeval huggingface dataset:
Interference of recombinant eglin C, a proteinase inhibitor extracted from leeches, with neutrophil-mediated platelet activation. (1990)

Eglin C is an inhibitor of two serine proteinase-derived polymorphonuclear leucocytes (PMN) i.e., elastase and cathepsin G. Since the latter has recently been shown to be involved in the activation of platelets by stimulated PMN, the effects of recombinant eglin C in the PMN-platelet cooperation model were studied. First, the inhibitory capacity of eglin C against purified cathepsin G was measured spectrophotometrically by following hydrolysis of a specific synthetic substrate, N-succinyl-ala-ala-pro-phe-para-nitroanilide. The inhibition of the enzymatic activity of 180 nM (5 micrograms/ml) cathepsin G was directly proportional to eglin C concentration and reached 100% with 2 micrograms/ml (240 nM). Platelet activation generated by a submaximal concentration of cathepsin G (200 nM) was also totally suppressed by 2 micrograms/ml of eglin C. Inhibition was specific (a 100 times higher concentration of eglin C did not alter platelet activation induced by thrombin), and surmountable (an increase of cathepsin G concentration reduced the eglin C effect). Thus, the mechanism of inhibition by eglin C of cathepsin G-induced platelet activation could be explained by a stoichiometric relation between eglin C and cathepsin G as previously described. Investigations were then performed with the PMN-platelet cooperation model, using two distinct stimuli, N-formylmethionylleucylphenylalanine (FMLP) or recombinant human C5a, at submaximal concentrations, 2.10(-7) M and 10(-7) M, respectively. A concentration-dependent inhibition of platelet activation aggregation and serotonin release-lambda was observed. Eglin C used at 10 micrograms/ml and 25 micrograms/ml totally blocked the platelet responses induced by recombinant human C5a and FMLP, respectively. Leucotriene B4, but also thromboxane B2 production measured by radioimmunoassays, were observed under FMLP activation. In the presence of eglin C, thromboxane B2 formation was totally suppressed, whereas leucotriene B4 synthesis was still effective. In fact, the mechanism of inhibition of eglin C is located neither on PMN (leucotriene B4 formation by FMLP-activated PMN was not affected), nor on platelets (response to thrombin was unchanged). The target is most probably cathepsin G since eglin C suppressed thromboxane B2 formation by platelets challenged by this serine proteinase. These results constitute an argument in favor of the implication of cathepsin G in the PMN-mediated platelet activation. Moreover, they reinforce the hypothesis that this mechanism could be operating under in vivo pathologic conditions, since eglin C is capable of preventing or ameliorating some experimental pulmonary diseases.
The quantitative spectrum of inositol phosphate metabolites in avian erythrocytes, analysed by proton n.m.r. and h.p.l.c. with direct isomer detection (1989)

The spectrum of inositol phosphate isomers present in avian erythrocytes was investigated in qualitative and quantitative terms. Inositol phosphates were isolated in micromolar quantities from turkey blood by anion-exchange chromatography on Q-Sepharose and subjected to proton n.m.r. and h.p.l.c. analysis. We employed a h.p.l.c. technique with a novel, recently described complexometric post-column detection system, called 'metal-dye detection' [Mayr (1988) Biochem. J. 254, 585-591], which enabled us to identify non-radioactively labelled inositol phosphate isomers and to determine their masses. The results indicate that avian erythrocytes contain the same inositol phosphate isomers as mammalian cells. Denoted by the 'lowest-locant rule' [NC-IUB Recommendations (1988) Biochem. J. 258, 1-2] irrespective of true enantiomerism, these are Ins(1,4)P2, Ins(1,6)P2, Ins(1,3,4)P3, Ins(1,4,5)P3, Ins(1,3,4,5)P4, Ins(1,3,4,6)P4, Ins(1,4,5,6)P4, Ins(1,3,4,5,6)P5, and InsP6. Furthermore, we identified two inositol trisphosphate isomers hitherto not described for mammalian cells, namely Ins(1,5,6)P3 and Ins(2,4,5)P3. The possible position of these two isomers in inositol phosphate metabolism and implications resulting from absolute abundances of inositol phosphates are discussed.
Einleitung (1997)

Beide Zitate stehen für eine zentrale Entwicklung im Rahmen des Marketing: der Kommunikationswettbewerb gewinnt gegenüber dem Produktwettbewerb an Bedeutung (vgl. Kroeber-Riel, 1984a; 1984b; 1993a, S. 20ff.; Kroeber-Riel/Weinberg, 1996, S. 220). Wettbewerbsvorteile können in gesättigten und durch eine starke Handelsmacht gekennzeichneten Märkten vor allem durch eigenständige und klare Markeneindrücke erreicht werden (vgl. Kroeber-Riel, 1986a; Keller, 1993, S. 2).1 Insofern ist die Markenpositionierung eine strategische Aufgabe und wird als das Hauptziel des Marketing angesehen (vgl. Kroeber-Riel, 1993a, S. 42; Meffert, 1988, S. 119). Die Positionierung hängt vor allem von Produkteindrücken, von Eindrücken der Produktverpackung und von werblichen Eindrücken ab und manifestiert sich in der Wahrnehmung der potentiellen Käufer durch entsprechende Gedächtnisstrukturen (vgl. Kroeber-Riel, 1986a; Nielsen, 1989; Alba / Hutchinson / Lynch, 1991, S. 15).
Iron-Binding Catechols and Virulence in <i>Escherichia coli</i> (1973)

A comparison of viral-induced unresponsiveness of phytohemagglutinin (PHA)-induced deoxyribonucleic acid (DNA) synthesis of mouse lymphocytes was made by culturing the cells under identical conditions in the presence of HEPES buffer in a humid-air atmosphere. The degree of PHA-induced DNA synthesis was found to vary, depending upon the type of ribonucleic acid or DNA virus treatment. Myxovirus, paramyxoviruses, Mengo virus, leukemic viruses, herpesvirus, and vaccinia virus caused a depression in responsiveness, whereas lactic dehydrogenase virus, adenovirus, and polyoma virus induced an increase in DNA synthesis. Inhibition of DNA synthesis was significant only if the virus was added at 0 h or within the first 12 h after PHA stimulation. Time studies indicated that leukemic and nonleukemic viruses caused similar patterns in the alteration of PHA-induced DNA synthesis.
Effects of dextran 70 versus crystalloids in the microcirculation of porcine hemorrhagic pancreatitis. (1986)

The cause of hemodynamic changes occurring during acute pancreatitis remains obscure. Using a pig model of acute hemorrhagic pancreatitis and the reference sample method with 113Tin and 46 Scandium labelled microspheres, blood flow to organs was determined before and five hours after the induction of pancreatitis. Blood pressure, pulse rate and cardiac output were measured hourly. There were two treatment groups. The first group received dextran 70 (5.7 milliliters per kilogram per hour) and saline solution (7.5 milliliters per kilogram per hour) in sufficient amounts to maintain cardiac output at the initial (prepancreatic) level. The second group received saline solution (26 milliliters per kilogram per hour) only and during the experiment the cardiac output was allowed to decrease to approximately one-half of the initial level. In the dextran 70 group, blood flow in various organs stayed at the initial level or was slightly increased. However, in the saline solution group there was a marked and significant decrease in the blood flow in all organs except the antral mucosa, gallbladder and adrenal glands. The changes in the pancreatic fraction of the cardiac output during the experiment were similar to those of other organs in respective treatment groups. In conclusion, adequate infusion of dextran maintains cardiac output and organ microcirculation at the initial level during the early phase of acute hemorrhagic pancreatitis. It is suggested that the hemodynamic changes which develop during acute pancreatitis are mainly secondary to the ensuing hypovolemia and not direct consequences of the pancreatic inflammatory process.
An Automatic Scheduling Approach: Building Information Modeling-based Onsite Scheduling for Panelized Construction (2014)

Panelized/modular construction is increasingly adopted within the industry as a primary construction method, with in-plant fabrication and onsite assembly as two of the main processes. Each of these two processes involves a different emphasis regarding productivity improvement: for in-plant fabrication, manufacturing process management is the main focus, whereas for onsite assembly, scheduling and management of assembly operations are of particular interest. This paper proposes a generic approach by which to generate the onsite schedule automatically based on a Building Information Model (BIM), considering the structural supporting and topological relationships among building elements, as well as knowledge of steel panel construction. The BIM is developed in an Autodesk Revit environment, based on which precedence relationships of elements are derived automatically and is utilized to perform the onsite schedule through the Autodesk Revit application programming interface (API). The generated schedule results are exported into Microsoft Project for further analysis, such as resource leveling. A case example is provided to demonstrate and validate the methodology. This paper explores the implementation of BIM, with the scheduling of panelized construction as the focus. This research lays the foundation for further implementation of BIM using Autodesk Revit.
Toroidal microstructures from water-in-oil emulsions (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToroidal microstructures from water-in-oil emulsionsJoel M. WilliamsCite this: Langmuir 1988, 4, 1, 44–49Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://doi.org/10.1021/la00079a007RIGHTS & PERMISSIONSArticle Views391Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
Long-Term Outcome of Patients with Headache and Drug Abuse after Inpatient Withdrawal (1996)

Thirty-eight patients with "chronic daily" headache and ergotamine and/or analgesics abuse according to the criteria proposed by the International Headache Society were re-investigated 5 years after inpatient drug withdrawal. At the end of the observation period, 19 patients (50.0%) had their headaches on only 8 days per month or less, 18 patients (47.4%) were free of symptoms or had only mild headaches. A close correlation was found between the frequency of headache and the duration of drug abuse, as well as between the intensity of headache and the number of tablets taken per month. Frequency and intensity of headache had changed within the first 2 years after withdrawal, but remained stable afterwards. Fifteen patients (39.5%) reported on recurrent drug abuse. Patients with migraine showed a tendency towards a better prognosis compared to patients with tension-type headache or with combined migraine and tension-type headache. The results of this study highlight the long-term efficacy of inpatient drug withdrawal in patients with headache and ergotamine and/or analgesics abuse.
Human lung cell responses caused by roadside particle types (2019)

Particulate matter (PM), especially traffic-derived particles, is associated with adverse effects on human health. An in vitro dose-response methodology using human lung cells A549 was adopted to investigate lung cell culture responses [cytokine expression Interleukin (IL) –6, IL-8, and cell death] following incubation with traffic-derived particles. The basis of this study was to investigate interactions between the known components on ambient particles proximal to roadways. In using ambient particle type ERM-CZ120, and laboratory mimics of PM, cellular responses clearly indicate the importance of insoluble particle types that are internalized via endocytosis. Particle size appears to not be a principal factor, but particle-air interface chemistries, while not investigated in this work, are likely important. The soluble species used herein did not effect a response when introduced alone, but when combined with insoluble particle types, the cellular response in excess of the insoluble particle alone was measured. A probable mechanism is that the insoluble particles function as carriers, via endocytosis, and that process provides an access route for internalization of soluble species. As evidenced by one set of experiments, prediction of overall cellular response to a given dose of a specific particle type is not trivial. Ferrous iron, when introduced with silica particles, effected significant down-regulation of expressed cytokines, whereas lead ions effected significant up-regulation, but when ferrous iron and lead ions were co-administered with silica particles, cytokine expression was down-regulated. These results indicate the necessity to measure specific cellular responses as an outcome following a dose with a specific particle composition of insoluble and soluble components for which detailed physical and chemical composition information is known, and not to extrapolate to other particle types.
Experimental Studies and Rate-Based Process Simulations of CO<sub>2</sub> Absorption with Aqueous Ammonia Solutions (2012)

A pilot plant at laboratory scale for absorption of CO2 has been constructed and operated to test the CO2 removal by aqueous ammonia solutions. The design of the pilot plant is based on a standard absorption and desorption flow sheet and partial or complete separation of gas mixtures. Pilot plant data for CO2 removal efficiencies, effects of CO2 loading, and temperature profiles are obtained. A rate-based model, RateFrac in Aspen Plus simulator, is used to simulate the CO2 absorption of the pilot plant. The simulation results of the CO2 capture predicted by the rate-based model are in good agreement with the experimental data of the pilot plant. Further, the optimization covering operational parameters is carried out using the rate-based model.
Calcific aortic stenosis: another face of atherosclerosis? (2003)

Calcific aortic stenosis is not the result of decades of wear and tear alone. Rather, it is being increasingly recognized as an inflammatory, atheromatous, and potentially modifiable disease. Exciting new research suggests that medical therapies may soon be available to retard its progression and reduce the need for surgery.
Clevudine, to Treat Hepatitis B Viral Infection (2010)

This chapter contains sections titled: Current Status of Anti-HBV Agents Chemical Evolution of Clevudine Metabolism and Mechanism of Action Pharmacokinetics Clinical Studies Drug Resistance Toxicity and Tolerability Dosage and Administration Combination Therapy Summary References
Soft-Ground Arresting System for Commercial Aircraft (1993)

A soft-ground arresting system provides an economical and nondestructive means for decelerating an aircraft that would otherwise be unable to stop safely within the confines of the runway including the safety or overrun area. This report validates a mathematical model developed to predict deceleration of an aircraft as it travels through a soft-ground arresting system. Full-scale tests were conducted at the Federal Aviation Administration Technical Center using the FAA's instrumented B-727 aircraft. The speed of the aircraft entering the beds ranged from 20 to 80 knots. The dimensions of the bed were as follows: foam thickness range was from 6 to 18 inches; test bed length was from 88 to 176 feet; width was always 40 feet. In each test the deceleration experienced by the aircraft was recorded in addition to its velocity, landing gear loads, and brake torque. The results of these tests showed that actual measured parameters from the aircraft were within 10 percent of the values predicted by the mathematical model; thus validating the accuracy of this model. The 18-inch-thick foam bed provided the most effective deceleration without exceeding the stresses encountered by the aircraft during normal operation. Fire and rescue equipment can maneuver and conduct emergency operations within the foam arrestor bed without difficulty.
Embedded System Design for Automotive Applications (2007)

To optimize the system design and allow for plug and play of subsystems, automotive electronic system architecture evaluation and development must be supported with a robust design flow based on virtual platforms.
Towards A Dynamic Object-Oriented Design Metric Plug-in Framework (2008)

Problem Statement: The evolution of software is made difficult by the need to integrate new features with all previously implemented features in software applications. Approach: present study introduced a general-purpose, platform-independent object-oriented design metric plug-in framework called jmetric intended to help building scalable, extendable object-oriented design metric plug-ins. jmetric seeks to address problem by providing the plug-in developer a structured way to separately develop and incrementally integrate independent object-oriented design metrics as plug-ins to a domain specific object-oriented design metrics framework. jmetric was engineered to provide functional building blocks to accelerate the adding, removing and updating of object-oriented design metric plug-ins in tools such as Eclipse, JDeveloper, NetBeans, JBuilder and other Java-based tools. Dependency injection is heavily used in jmetric to accelerate the adding, removing and updating of object-oriented metrics plug-ins. We studied several commonly used integrated development environments and software metrics tools to identify the extendibility of the tools to provide additional object-oriented design metric functionalities as plug-ins. Results: We demonstrate a tool called jmetric tool that had developed as a reference implementation to validate the plug-in capabilities of jmetric. Conclusion: Extending other tools such as Eclipse, JDeveloper and NetBeans to include metric functionalities is possible by wiring plug-ins through dependency injection mechanism in jmetric.
Relations between ac-dc components and optical path length in photoplethysmography (2011)

Photoplethysmography is used in various areas such as vital sign measurement, vascular characteristics analysis, and autonomic nervous system assessment. Photoplethysmographic signals are composed of ac and dc, but it is difficult to find research about the interaction of photoplethysmographic components. This study suggested a model equation combining two Lambert-Beer equations at the onset and peak points of photoplethysmography to evaluate ac characteristics, and verified the model equation through simulation and experiment. In the suggested equation, ac was dependent on dc and optical path length. In the simulation, dc was inversely proportionate to ac sensitivity (slope), and ac and optical path length were proportionate. When dc increased from 10% to 90%, stabilized ac decreased from 1 to 0.89 ± 0.21, and when optical path length increased from 10% to 90%, stabilized ac increased from 1 to 1.53 ± 0.40.
High Yield Soybean Management: Planting Practices, Nutrient Supply, and Growth Modification (2013)

Growers are constantly seeking ways to improve yield in soybean [Glycine max (L.) Merr.]. There has been much interest in the use of selected alternative practices to maximize soybean yield. These practices include planting soybean at higher than recommended seeding rates, planting soybean in narrow rows, breaking apical dominance to induce branching, application of strobilurin fungicides prophylactically to minimize disease and extend the seed filling period, the use of N fertilizer both in furrow and foliar applied, and the use of seed treatments to promote early stand establishment and health. Field studies were conducted at the University of Nebraska West Central Research and Extension Center in North Platte, Nebraska, and at the West Central Water Research Field Laboratory located near Brule, Nebraska and at Bancroft, Clay Center, Cortland, and Elba, Nebraska to determine how these practices affect soybean yield. Increased seeding rate also increased soybean yield and 24.7, 43.2, and 61.8 planted seeds m-2 yielded 4.47, 4.79, and 4.79 Mg ha-1, respectively. Soil fertility, application of strobilurin and seed treatments did not affect yield. Decreases in yield were observed by destroying the apical meristem by both clipping at V2 and application of lactofen. These results suggest that soybean yield is optimized in west central Nebraska by planting soybean at between 24.7 and 43.2 seeds m-2 but not applying lactofen or pyraclostrobin. Growers should be very careful in selecting alternative practices due to the possible reduction in soybean yield. Advisors: Greg R. Kruger and Charles S. Wortmann
Ageing of the heart. (1998)

Ageing of the heart is associated with a number of characteristic morphological, histological and biochemical changes. However, not all observed changes with age are associated with a deterioration in function. The high prevalence of hypertension and ischaemic heart disease makes distinction between normal ageing changes and the effects of underlying cardiovascular disease processes difficult. In this review, an attempt has been made to separate age-related changes from those related to disease, and to outline their significance for cardiac performance. Disease-independent changes in the ageing heart which are associated with a reduction in function include a reduction in the number of myocytes and cells within the specialised conduction tissue, the development of cardiac fibrosis, a reduction in calcium transport across membranes, lower capillary density and decreases in the intracellular response to beta-adrenergic stimulation. Other characteristic changes, such as epicardial fat deposition and 'brown atrophy' due to intracellular lipofuscin deposits, appear to be merely symptomatic of the ageing process without any obvious effects on function. Some of the age-associated changes in the heart can be reversed, at least partially, by exercise or specific drugs. It remains, however, unclear whether this would result in any definite advantages for the individual. The mechanisms guiding proliferation or non-proliferation of myocytes and the development of fibrosis are current topics for research and may lead to new preventive approaches to ageing processes in the heart.