gebhart/patrepeval huggingface dataset:
Effect of Cigarette Smoke Extract on Nitric Oxide Synthase in Pulmonary Artery Endothelial Cells (1998)

Cigarette smoking is associated with impaired endothelium-dependent vasodilation and reduced nitric oxide (NO) in the exhaled air of smokers. To explore the mechanism for the impairment of NO-mediated vasodilation, we studied the effect of cigarette smoke extract (CSE) on NO synthase (eNOS) activity and content in pulmonary artery endothelial cells (PAEC). Incubation of PAEC with CSE resulted in a time- and dose-dependent decrease in eNOS activity. The inhibitory effect of CSE on eNOS activity was not reversible. Both gas-phase and particulate-phase extracts of CSE contributed to the inhibition of eNOS activity. The protein kinase c (PKC) inhibitors staurosporine and chelerythrine did not affect the CSE-induced inhibition of eNOS activity. Catalase, superoxide dismutase (SOD), vitamin C, vitamin E, glutathione, and dithiothreitol (DTT) also did not prevent the CSE-induced inhibition of eNOS activity, and incubation of PAEC with 3 mM nicotine did not change the activity of eNOS. Treatment of PAEC with CSE also caused a nonreversible, time-dependent decrease in eNOS protein content detected by Western blot analysis, and in eNOS messenger RNA (mRNA) detected by Northern blot analysis. Treatment of PAEC with CSE had no effect on cell protein or glutathione contents or on lactate dehydrogenase (LDH) release. These results indicate that exposure to CSE causes an irreversible inhibition of eNOS activity in PAEC, and suggest that the decreased activity is secondary to reduced eNOS protein mass and mRNA. The decrease in eNOS activity may contribute to the high risk of pulmonary and cardiovascular disease in cigarette smokers.
Handbook of Disinfectants and Antiseptics (1995)

This work details current medical uses of antiseptics and disinfectants, particularly in the control of hospital-acquired infections. It presents methods for evaluating products to obtain regulatory approval, and examines chemical, physical and microbiological properties as well as the toxicology of the most widely-used commercial chemicals. Formul
Bayesian estimation supersedes the t test. (2012)

Bayesian estimation for 2 groups provides complete distributions of credible values for the effect size, group means and their difference, standard deviations and their difference, and the normality of the data. The method handles outliers. The decision rule can accept the null value (unlike traditional t tests) when certainty in the estimate is high (unlike Bayesian model comparison using Bayes factors). The method also yields precise estimates of statistical power for various research goals. The software and programs are free and run on Macintosh, Windows, and Linux platforms.
Coal users look at shipping alternatives (1978)

RETURN TO ISSUEPREVNewsNEXTCoal users look at shipping alternativesCite this: Chem. Eng. News 1978, 56, 45, 24–26Publication Date (Print):November 6, 1978Publication History Published online7 November 2010Published inissue 6 November 1978https://doi.org/10.1021/cen-v056n045.p024aCopyright © 1978 AMERICAN CHEMICAL SOCIETYArticle Views6Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (487 KB) SUBJECTS:Coal Get e-Alerts
Herbicides that inhibit cellulose biosynthesis (1999)

The cellulose-biosynthesis inhibitor (CBI) herbicides all selectively inhibit the synthesis of cellulose despite significant chemical differences. With the exception of quinclorac, they are most effective in inhibiting cellulose synthesis in dicot plants. Dichlobenil and isoxaben are the oldest and best studied of these herbicides, whereas flupoxam is a more recent introduction and acts in many ways similarly to isoxaben. Quinclorac is unusual in that it seems to act as a cellulose inhibitor in grasses but as an auxinic herbicide in dicots. These herbicides inhibit cell plate formation at one of two relatively late stages without affecting microtubule function. The effects of dichlobenil are different from other CBI herbicides; dichlobenil inhibits cellulose synthesis but promotes callose synthesis in its place. Suspension cells of both Lycopersicon esculentum and Nicotiana tabacum can become habituated to normally inhibitory concentrations of dichlobenil or isoxaben by replacing the normal cellulose network in their walls with pectin and extensin. Natural resistance to CBI herbicides is rare and has only been found in red algae species. Arabidopsis lines produced by mutagenesis all share changes in active site rather than alterations in uptake, translocation, or metabolism of these herbicides. The lack of cross-resistance to different CBI herbicides of these mutants indicates that no fewer than three different sites in the cellulose biosynthesis pathway are affected by the different herbicides in this class.
TESTING FOR MULTIPLE BUBBLES: LIMIT THEORY OF REAL‐TIME DETECTORS (2015)

This article provides the limit theory of real‐time dating algorithms for bubble detection that were suggested in Phillips, Wu, and Yu (PWY; International Economic Review 52 [2011], 201–26) and in a companion paper by the present authors (Phillips, Shi, and Yu, 2015; PSY; International Economic Review 56 [2015a], 1099–1134. Bubbles are modeled using mildly explosive bubble episodes that are embedded within longer periods where the data evolve as a stochastic trend, thereby capturing normal market behavior as well as exuberance and collapse. Both the PWY and PSY estimates rely on recursive right‐tailed unit root tests (each with a different recursive algorithm) that may be used in real time to locate the origination and collapse dates of bubbles. Under certain explicit conditions, the moving window detector of PSY is shown to be a consistent dating algorithm even in the presence of multiple bubbles. The other algorithms are consistent detectors for bubbles early in the sample and, under stronger conditions, for subsequent bubbles in some cases. These asymptotic results and accompanying simulations guide the practical implementation of the procedures. They indicate that the PSY moving window detector is more reliable than the PWY strategy, sequential application of the PWY procedure, and the CUSUM procedure.
NEW APPROACHES TO YARD AUTOMATION IN JAPAN (1979)

Automation features in Musashino Yard of the Japanese National Railroads are presented and discussed.
Statically Typed Document Transformation: An XTATIC Experience (2005)

XTATIC is a lightweight extension of C⋕ with native support for statically typed XML processing. It features XML trees as built-in values, a refined type system based on regular types à la XDUCE, and regular patterns for investigating and manipulating XML. We describe our experiences using XTATIC in a real-world application: a program for transforming XMLSPEC, a format used for authoring W3C technical reports, into HTML. Our implementation closely follows an existing one written in XSLT, facilitating comparison of the two languages and analysis of the costs and benets—both signicant—of rich static typing for XML-intensive code.
Ruthenium imidazole oxime carbonyls and their activities as CO-releasing molecules (2012)

Carbon monoxide has been found to possess various beneficial effects in living organisms. To study the effects of CO further and to develop potential pharmaceutical agents, a meaningful method for delivering CO to the target organ is needed. It has been found that under physiological conditions various metal carbonyl complexes release carbon monoxide. In this study six novel ruthenium carbonyl complexes Ru(IMOX)(CO)(2)(COOR)Cl(1) (IMOX: imidazolecarbaldehyde oxime, R: Me, Et) were prepared and tested as carbon monoxide releasing molecules (CORMs). Synthesis of the complexes was performed under mild conditions in alcoholic solutions. The ability to release CO was tested spectrophotometrically by following the transformation of deoxymyoglobin to carbonmonoxy myoglobin. All of the complexes studied were found to release CO. Compared to formerly studied ruthenium-based CORMs these complexes offer a way for slower CO release.
An Alternative Approach for Controlling Statistical AuditSampling Risks (1991)

Traditional approaches to risk control used for planning, executing, and evaluating substantive audit tests focus primarily on the risk of accepting a materially misstated amount (β risk) and only consider passively the risk of rejecting a correctly stated amount (α risk). This article discusses an alternative – the trade‐off approach – that formally considers both risks. Although the traditional and the trade‐off approach frequently lead to the same statistical conclusion, there are some applications in which only the trade‐off approach, can provide a statistical conclusion in support of the auditor′s assertion that a client′s balance is correctly stated. The article identifies these applications and suggests that the trade‐off approach merits further consideration.
The prospects for peroxidase-based biorefining of petroleum fuels (2007)

Peroxidases have many potential uses for biotechnological processes. In this review, peroxidase-catalyzed reactions potentially applicable to the petroleum industry are described. Although peroxidases are attractive catalysts for desulfurization, aromatic oxidation and asphaltene transformation, there are important issues that must be overcome before any industrial application can be considered. The opportunities and challenges of enzymatic petroleum biorefining are documented and discussed, with emphasis on the available tools to design a biocatalyst with appropriate performance for the oil and other industries.
Serum 25-Hydroxyvitamin D and Hip Fracture Risk in Older U.S. White Adults (2007)

Serum 25(OH)D was related to a significantly lower hip fracture risk in this cohort of older white adults, even after adjusting for several relevant confounding variables. The relationship did not seem to be linear across all values. Our results support other studies suggesting that serum 25(OH)D values exceeding 60 nM are associated with health benefits.
The novel amyloid-beta peptide aptamer inhibitsintracellular amyloid-beta peptide toxicity (2013)

Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-ABAD-DP-TRX2 aptamer. Moreover, adeno-associated virus was used to allow its stable expression. Immunofluorescent staining revealed the co-expression of the transduced fusion gene TRX1-ABAD-DP-TRX2 and amyloid β peptide in NIH-3T3 cells, indicating that the TRX1-ABAD-DP-TRX2 aptamer can bind amyloid β peptide within cells. In addition, cell morphology and MTT results suggested that TRX1-ABAD-DP-TRX2 attenuated amyloid β peptide-induced SH-SY5Y cell injury and improved cell viability. These findings confirmed the possibility of constructing TRX-based peptide aptamer using ABAD-DP. Moreover, TRX1-ABAD-DP-TRX2 inhibited the cytotoxic effect of amyloid β peptide.
A framework for high‐performance matrix multiplication based on hierarchical abstractions, algorithms and optimized low‐level kernels (2002)

Abstract Despite extensive research, optimal performance has not easily been available previously for matrix multiplication (especially for large matrices) on most architectures because of the lack of a structured approach and the limitations imposed by matrix storage formats. A simple but effective framework is presented here that lays the foundation for building high‐performance matrix‐multiplication codes in a structured, portable and efficient manner. The resulting codes are validated on three different representative RISC and CISC architectures on which they significantly outperform highly optimized libraries such as ATLAS and other competing methodologies reported in the literature. The main component of the proposed approach is a hierarchical storage format that efficiently generalizes the applicability of the memory hierarchy friendly Morton ordering to arbitrary‐sized matrices. The storage format supports polyalgorithms, which are shown here to be essential for obtaining the best possible performance for a range of problem sizes. Several algorithmic advances are made in this paper, including an oscillating iterative algorithm for matrix multiplication and a variable recursion cutoff criterion for Strassen's algorithm. The authors expose the need to standardize linear algebra kernel interfaces, distinct from the BLAS, for writing portable high‐performance code. These kernel routines operate on small blocks that fit in the L1 cache. The performance advantages of the proposed framework can be effectively delivered to new and existing applications through the use of object‐oriented or compiler‐based approaches. Copyright © 2002 John Wiley & Sons, Ltd.
An apparatus using the Faraday effect to locate the magnetic axis of quadrupole magnets (1994)

A development using magneto-optic sensors is underway for the location of the magnetic center of long, small aperture, superconducting quadrupole magnets. The paper describes the measuring methods and the preliminary results which have been obtained with gradients from 2.5 T/m to 10 T/m. The sensors are made of magneto-optic garnets using the Faraday effect which changes an incident beam of linearly polarized light into a transmitted beam of elliptically polarized light. An optical fiber bundle (O<20 /spl mu/m) carries the incident light to a polarized film, put above the magneto optic sensor. An analyzer film collects the transmitted light. A second optic fiber bundle carries this light toward a visual (microscope, video camera) or analogic data acquisition system. Furthermore, a level is associated with these crystals to determine the gravity direction. The "mole" is moving along the axis of a warm bore tube when the magnet is superconducting. The present results are promising for measuring quadrupoles of much higher gradients, up to 100 T/m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lecerf, Bernard and Ian Robinson. Les Ovni. Scarborough, Ontario: Prentice-Hall of Canada Limited, 1978 (1979)

"Lecerf, Bernard and Ian Robinson. Les Ovni. Scarborough, Ontario: Prentice-Hall of Canada Limited, 1978." Canadian Modern Language Review, 36(1), pp. 127–128
IP traceback-based intelligent packet filtering: A novel technique for defending against internet DDoS attacks (2003)

Distributed Denial of Service (DDoS) is one of the most difficult security problems to address. While many existing techniques (e.g., IP traceback) focus on tracking the location of the attackers after-the-fact, little is done to mitigate the effect of an attack while it is raging on. We present a novel technique that can effectively filter out the majority of DDoS traffic, thus improving the overall throughput of the legitimate traffic. The proposed scheme leverages on and generalizes the IP traceback schemes to obtain the information concerning whether a network edge is on the attacking path of an attacker ("infected") or not ("clean"). We observe that, while an attacker will have all the edges on its path marked as "infected," edges on the path of a legitimate client will mostly be "clean". By preferentially filtering out packets that are inscribed with the marks of "infected" edges, the proposed scheme removes most of the DDoS traffic while affecting legitimate traffic only slightly. Simulation results based on real-world network topologies all demonstrate that the proposed technique can improve the throughput of legitimate traffic by three to seven times during DDoS attacks.
An overview of skin cancers (1995)

The incidence and mortality rates of skin cancer are rising in the United States and in many other countries. Concerns about stratospheric ozone depletion adding to the problem have made many organizations look at public and professional health programs as a possible solution. Early detection can reduce the problem in the short term, because mortality due to melanoma is clearly related to the depth of invasion of the tumor when it is removed. This is the factor which is amenable to change in an education program on early detection. Exposure to sunlight is clearly related to risk of development of skin cancer, including both melanoma and nonmelanoma skin cancers. This is the component of the equation of constitutional predisposition plus exposure to environmental risk factors leading to skin cancer that is amenable to change as a result of educational programs. On the basis of available data, there is a case for further development, provision, and evaluation of public and professional education programs designed to control what is becoming a major public health problem in the community.
Building a test platform for agents in power system control: Experience from SYSLAB (2007)

A tighter integration of information and communication technologies into power grids and a gradual decentralization of control are widely regarded as key responses to the transformation of power systems, even though many different approaches are investigated to achieve this. Lack of system-level simulation tools and the high risk of tests on a real-world power grid create a need for small, experimental grids on which new control concepts can be safely tested and demonstrated. In order to accommodate a wide range of possible control structures, the controller platform on such grids needs to be as flexible as possible. Software agents promise to be a programming paradigm in support of flexible, distributed applications. This paper describes their application in SYSLAB, an experimental facility for distributed power systems, and discusses experience gained in the implementation process.
Analytics of Surfactants in the Environment: Problems and Challenges (2011)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTAnalytics of Surfactants in the Environment: Problems and ChallengesEwa Olkowska*, Żaneta Polkowska, and Jacek NamieśnikView Author Information Department of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology (GUT), ul. G. Narutowicza 11/12, 80-233 Gdańsk, Poland,E-mail: [email protected]Cite this: Chem. Rev. 2011, 111, 9, 5667–5700Publication Date (Web):July 11, 2011Publication History Received7 April 2010Published online11 July 2011Published inissue 14 September 2011https://pubs.acs.org/doi/10.1021/cr100107ghttps://doi.org/10.1021/cr100107greview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views4420Altmetric-Citations117LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Extraction,Geological materials,Solvents,Surfactants Get e-Alerts
Codon Usage in <i>Tetrahymena</i> and Other Ciliates (1989)

Codon usage in ciliates was examined by analyzing the coding regions of 22 ciliate genes corresponding to a total of 26,142 nucleotides (8,714 codons). It was found that Tetrahymena, Paramecium and the hypotrichs (Oxytricha and Stylonychia) differed in which synonymous codons were used most frequently by their genes. In fact, the codon choices in highly expressed Tetrahymena genes were more similar to those of yeast genes than those of Paramecium genes. The ciliates do not appear to have unusually strong biases in codon usage frequency when compared to other protists such as yeast. The analysis of the Tetrahymena genes indicated that genes which are highly expressed during normal cell growth have a stronger bias towards using the "preferred" codons than those expressed at lower levels during growth or for brief periods during processes such as conjugation. This conforms to what is found in other protists.
Design process based on hardware description languages (2002)

The design process based on hardware description languages is described. The most important stages of the design flow and the tools involved are presented, from the specification to the final implementation. The advantages of using hardware description languages are highlighted, as well as the problems that may appear by their use. Although all the concepts and methods are feasible for any kind of digital electronic system, ASICs (Application Specific Integrated Circuits) are specially considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>