gebhart/patrepeval huggingface dataset:
Polyamines Regulate the Stability of JunD mRNA by Modulating the Competitive Binding of Its 3′ Untranslated Region to HuR and AUF1 (2010)

Polyamines critically regulate all mammalian cell growth and proliferation by mechanisms such as the repression of growth-inhibitory proteins, including JunD. Decreasing the levels of cellular polyamines stabilizes JunD mRNA without affecting its transcription, but the exact mechanism whereby polyamines regulate JunD mRNA degradation has not been elucidated. RNA-binding proteins HuR and AUF1 associate with labile mRNAs bearing AU-rich elements located in the 3' untranslated regions (3'-UTRs) and modulate their stability. Here, we show that JunD mRNA is a target of HuR and AUF1 and that polyamines modulate JunD mRNA degradation by altering the competitive binding of HuR and AUF1 to the JunD 3'-UTR. The depletion of cellular polyamines enhanced HuR binding to JunD mRNA and decreased the levels of JunD transcript associated with AUF1, thus stabilizing JunD mRNA. The silencing of HuR increased AUF1 binding to the JunD mRNA, decreased the abundance of HuR-JunD mRNA complexes, rendered the JunD mRNA unstable, and prevented increases in JunD mRNA and protein in polyamine-deficient cells. Conversely, increasing the cellular polyamines repressed JunD mRNA interaction with HuR and enhanced its association with AUF1, resulting in an inhibition of JunD expression. These results indicate that polyamines modulate the stability of JunD mRNA in intestinal epithelial cells through HuR and AUF1 and provide new insight into the molecular functions of cellular polyamines.
Critical Literacy, School Improvement, and the Four Resources Model (2017)

In this talk, Allan Luke introduces a four-part paradigm (coding practices, pragmatic practices, text-meaning practices, and critical practices) model for reading that encourages different levels of critical literacy. His talk addresses the model, school level, and the systemic and school reform regimes. He introduces and reviews the four resources comprising this model, and what they attempt to do. He then addresses his current and previous work in Ontario and Queensland, particularly how these states or jurisdictions have developed alternatives to mandated scripted reading pedagogy. The four resources model is presented as an organizing principle for whole school literacy plans.
Assessment of complex peptide degradation pathways via structured multicompartmental modeling approaches: The metabolism of dynorphin A1–13 and related fragments in human plasma (1999)

Peptide metabolic pathways in blood or other tissues are often complex because multiple enzyme systems are involved in the degradation of parent drug and its metabolites. Michaelis-Menten-type studies with isolated enzymes have been frequently employed for evaluating the metabolism of peptides. Alternatively, studies with selective enzyme inhibitors or the evaluation of the area under the drug- or metabolite-time profiles have been employed. We tested in this study the usefulness of a multicompartmental pharmacokinetic approach for the assessment of the apparent first-order metabolism of dynorphin A1-13 up to the fourth metabolite generation in human plasma. This multicompartmental kinetic analysis proved instrumental in clarifying ambiguous degradation pathways not easily detectable by the other methods of assessment (enzyme inhibition studies and noncompartmental analysis) because of the lack of specific enzyme inhibitors or specificity problems of the analytical technique employed. The proposed multicompartmental fitting approach was also highly suitable to verify the overall metabolic pathways suggested by the other methods up to the fourth metabolite by testing whether the rate constants obtained by these methods are suitable to describe the overall degradation profile after Dyn A1-13 degradation. Local sensitivity analysis for the degradation of DYNA 1-13 revealed that the model was, however, not able to adequately identify on its own all of the parameters involved in the degradation of dynorphin A1-13. Thus, the method proved beneficial in evaluating and testing the correctness of the overall degradation pathways suggested by other methods.
Ministerial meeting shows EU member states’ commitment to tackling HIV/AIDS, and current and future threats (2005)

Health ministers from all 25 countries of the European Union met with the European Commissioner for Health and Consumer protection in Paris for an informal EU health ministerial meeting on cancer, HIV/AIDS and influenza
convenient Access to Methylthiomethyl Esters. Esterification with Chlorodimethylsulfonium Salts (1979)

Abstract Our reports1,2 on the preparation, cleavage, and the facile transesterification and aminolysis of methylthiomethyl (MTM) esters have apparently aroused interests in the general use of the MTM group for protection of hydroxy functions.3,4 A recent note5 describing an alternative path to and hydrolysis of MTM esters prompts me to disclose a truly mild method for MTM ester synthesis. The procedure of Wade et al.5 is in fact less convenient than that of our original work, with respect to both the esterification and the hydrolysis steps.
Antibody-Dependent Cell-Mediated Cytotoxicity to Target Cells Infected with Type 1 and Type 2 Herpes Simplex Virus (1976)

The phenomenon of antibody-dependent cell-mediated cytoxicity (ADCC) has been extended to include target cells acutely infected with herpes simplex type 1 virus (HSV-1) or herpes simplex type 2 virus (HSV-2) in an in vitro system that employs immune human serum and human blood mononuclear cells. The cytotoxic reaction was detectable after 1 hr of incubation and was complete between 4 and 8 hr. The amount of ADCC noted was directly proportional to the logarithm(10) of the effector: target cell ratio (E:T), and ADCC was noted at E:T as low as 1:1. The mononuclear effector cell was present in the blood of both HSV immune and non-immune individuals. The immune serum factor was demonstrated to be an antibody with specificity for HSV membrane antigen(s) and was reactive with target cells infected with either of the two HSV types. The antibody rendered the mononuclear cell cytotoxic by sensitization of the target cell rather than by direct attachment to or "arming" of the mononuclear cell. The physiochemical properties of the antibody as well as its presence in cord blood demonstrated that it is an immunoglobulin on the IgG class.
The crystal and molecular structure of ammonium µ-nitrido-bis[aquotetrachlororuthenate(<scp>IV</scp>)] (1971)

The crystal and molecular structure of ammonium µ-nitrido-bis[aquotetrachlororuthenate(IV)], (NH4)3[Ru2NCl8–(H2O)2], has been determined from X-ray diffractometer data (MoK-α radiation, R= 0·071 for 1054 reflections). Unit cell dimensions are a= 15·910 Å, b= 7·642 Å, c= 8·399 Å, γ= 121·09° with two molecules per unit cell, in space group B2/m. The compound contains ammonium cations and complex [Ru2NCl8(H2O)2]3– anions. The co-ordination about the two metal atoms in the anion is approximately octahedral. The two octahedra are joined by a bridging nitrogen atom, which is at a centre of symmetry. The Ru–N distances are very short, 1·725 Å, indicating multiple bonding. The two independent Ru–Cl distances are 2·370 Å and 2·391 Å. The Ru–O(water) distance of 2·20 Å is long by comparison with previously reported values.
Analyzing the Gap Between Workflows and their Descriptions (2009)

Scientists increasingly use workflows to represent and share their computational experiments. Because of their declarative nature, focus on pre-existing component composition and the availability of visual editors, workflows are often seen as more “natural ” than programming or scripting languages for representing data analysis procedures. However, there is still a significant gap between the naturalness of workflow representations and natural language. In this paper, we aim to identify key constructs that intelligent workflow systems could support to allow for more natural workflow representations. These constructs are identified through a comparison of bioinformatics workflows and their associated descriptions obtained from the virtual research environment myExperiment.
Performance analysis of Go-Back-N ARQ scheme on parallel channel system (1998)

In a parallel channel system, some idle channels appear if the packets waiting for transmission are less than the number of parallel channels in a slot. This paper considers a two-parallel-channel system under the Go-Back-N ARQ scheme. To effectively use the idle channels, we propose a modified packet assignment method based on the basic method. The basic assignment method assigns the packet of smaller sequence number to the higher-quality channel, and the modified one effectively uses the idle channels in the basic assignment method by transmitting packet copies in the idle channels. The queue lengths in the transmission buffer for both the basic and modified assignment methods are analyzed. Also the delay times are investigated by computer simulation. The numerical results show that although the throughput for the basic method is identical to that for the modified one, the average queue length and the delay time are remarkably reduced by the modified method. © 1998 Scripta Technica. Electron Comm Jpn Pt 1, 81(2): 10–20, 1998
Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle (2004)

Relaxin (RLX) is a pregnancy-associated polypeptide hormone. In non-pregnant women, the peak of circulating relaxin coincides with the window of endometrial receptivity and both in vivo and in vitro experiments showed that it plays a role in the decidualization process. Recently, two receptors, LGR7 and LGR8, have been identified as high affinity receptors for relaxin. Here we describe LGR7 mRNA and protein expression in human endometrium using semi-quantitative and quantitative fluorescent PCR (Q-PCR) and immunohistochemical analyses. Three different experimental designs were used. First, endometrial biopsies from five different phases of the menstrual cycle were analysed. Secondly, we assessed the early luteal phase in more detail. Finally we analysed the expression at LH+2 (2 days after the natural LH surge, pre-receptive endometrium) versus LH+7 (receptive endometrium) within the same menstrual cycle from the same patient to avoid inter-cycle or inter-person variations in gene expression. Our results indicate that there is no consistent regulation of LGR7 mRNA expression, neither during the menstrual cycle nor during the early-mid-luteal phase. In general, we observed a large degree of variation in LGR7 mRNA expression levels between patients. LGR7 immunoreactive protein was identified in all stages of the menstrual cycle. LGR7 protein was localized in both the epithelial and the stromal compartments, except for the mid-luteal phase when the expression was restricted to the endometrial epithelium. We conclude that no consistent regulation of LGR7 mRNA expression can be detected in human endometrium during the menstrual cycle.
Implementation of generalized uniform Bandpass Sampling with complex FIR and IIR Filtering (2007)

Bandpass sampling (BPS) realizes frequency down-conversion in radio receiver front-ends by a sampling rate that can be slightly larger than twice the information bandwidth compared to twice the highest frequency for traditional lowpass sampling (LPS). However, some implementation problems, harmful signal spectral folding, noise aliasing and sampling jitter, are unavoidably present in conventional BPS systems. Under recent research, generalized bandpass sampling combined with filtering has been proposed for dealing with these problems. In this paper, the novel sampling architectures with intrinsic filtering are implemented using a sampled-data technique called switched-capacitor (SC) circuit technique. Specifically complex SC filtering is designed and analyzed. Both the analysis and simulation results show that the designed complex SC filter fulfils the expectations of generalized bandpass sampling.
Immunosuppression and cytokine production in mice infested with <i>Ixodes ricinus</i> ticks: a possible role of laminin and interleukin‐10 on the <i>in vitro</i> responsiveness of lymphocytes to mitogens (1996)

T cells from BALB/c mice infested 9 days before with Ixodes ricinus nymphs had a suppressed response to in vitro concanavalin A (Con A) stimulation compared to cells from uninfested mice. When laminin (the main component of the extracellular matrix) was used as a coating agent, the Con A response of naive mice was characterized by a decrease in cell proliferation, whereas there was no significant effect on the mitogen response of cells from infested mice. In contrast, an increased response to lipopolysaccharide (LPS) was observed when assaying lymph node cells of infested mice, probably reflecting an increase in B-lymphocyte number or activity. LPS cell stimulation was not modified by laminin. Supernatants of lymph node cells, taken 9 days after the first infestation of mice, stimulated with Con A in vitro, contained interleukin-10 (IL-10) but no significant levels of IL-5 as tested by enzyme-linked immunosorbent assay. At this stage of the infestation all T cells reactive with tick antigens generated in lymph nodes that drain the tick fixation site, were CD4+ cells, as determined by CD4+ depletion. With cells taken 9 days after the third infestation an increase of IL-5 and IL-10 was observed. The IL-10 levels were higher than the IL-5. According to these observations, we conclude that the reduction of T-cell proliferation in response to Con A observed in lymph node cells from infested mice, may be due to the combined effect of laminin interaction with T lymphocytes during migration and IL-10 production by these lymphocytes.
ESTABLISHING THE FEASIBILITY OF DIRECT OBSERVATION IN THE ASSESSMENT OF TICS IN CHILDREN WITH CHRONIC TIC DISORDERS (2006)

Behavior analysis has been at the forefront in establishing effective treatments for children and adults with chronic tic disorders. As is customary in behavior analysis, the efficacy of these treatments has been established using direct-observation assessment methods. Although behavior-analytic treatments have enjoyed acceptance and integration into mainstream health care practices for tic disorders (e.g., psychiatry and neurology), the use of direct observation as a primary assessment tool has been neglected in favor of less objective methods. Hesitation to use direct observation appears to stem largely from concerns about the generalizability of clinic observations to other settings (e.g., home) and a lack of consensus regarding the most appropriate and feasible techniques for conducting and scoring direct observation. The purpose of the current study was to evaluate and establish a reliable, valid, and feasible direct-observation protocol capable of being transported to research and clinical settings. A total of 43 children with tic disorders, collected from two outpatient specialty clinics, were assessed using direct (videotape samples) and indirect (Yale Global Tic Severity Scale; YGTSS) methods. Videotaped observation samples were collected across 3 consecutive weeks and two different settings (clinic and home), were scored using both exact frequency counts and partial-interval coding, and were compared to data from a common indirect measure of tic severity (the YGTSS). In addition, various lengths of videotaped segments were scored to determine the optimal observation length. Results show that (a) clinic-based observations correspond well to home-based observations, (b) brief direct-observation segments scored with time-sampling methods reliably quantified tics, and (c) indirect methods did not consistently correspond with the direct methods.
Supporting remote reference updating through garbage collection in a mobile object system (2002)

Programming paradigms based on object mobility, such as mobile agents, can greatly contribute in designing distributed applications, but also introduce issues which are not present when objects are statically bound to their execution environments. Auxiliary mechanisms are necessary in order to allow an application to control mobile objects as well as to provide mobile agents with the capability of interacting with each other despite of mobility. The work described in this paper deals with how to build a mobile objects system based on the Java distributed object model. In particular we describe how to take advantage of the Java RMI's distributed garbage collector to implement an effective remote reference updating scheme, necessary, to support object interaction even in the presence of mobility.
The Ellery Lecture 1993: Pulsars—Setting the Standard (1994)

Abstract Over 600 pulsars are now known, almost all of which lie in our Galaxy. Most pulsars have periods between 0 · 1 and a few seconds, but a very important sub-class, the ‘millisecond’ pulsars, have much shorter periods. Millisecond pulsars are often in a binary orbit with another star, suggesting that their short periods are a result of accreting mass from the companion star. They are also extraordinarily good clocks, with a stability comparable to that of the best atomic clocks. This combination of extreme period stability and binary motion has led to some very important results, including the first observational evidence for gravitational radiation and the first evidence for extra-solar planetary systems. It is probable that pulsars will be used to define the long-term standard of terrestrial time. A search of the southern sky using the Parkes radio telescope has found several millisecond pulsars which will make an important contribution to these precision-timing programs.
Single-Crystal Fiber Optical Devices: I. A Nd:YAG Fiber Laser (1975)

The advent of low-loss optical fibers has created interest in fiber-compatible optical devices. We describe here the adaptation of a zone-melting technique,(1) previously used for growing single-crystal (SC) refractory-material fibers for high-strength applications,(2,3) to the fabrication of a single-crystal Nd:YAG fiber laser. This technique also may be used with suitable materials for the fabrication of a number of other single-crystal fiber-geometry devices including, for example, modulators, switches, Raman and Brillouin amplifiers and three-wave interaction devices. Since the small cross section of fibers permits high optical power density without overheating and provides opportunities for phase matching through angle (mode) matching to obtain long interaction paths, a number of such devices for low-power CM applications should be possible.
Stationary lead-acid batteries remote monitoring system (2011)

This work describe the research to the development of a remote monitoring system to obtain premature failures diagnoses in stationary lead-acid batteries (flooded and valve regulated) by measurements of its internal resistance and voltage. All the management and analysis of these measurements are included as a new feature of the "Battery Management Software", presented at INTELEC 2010.
Carbon and Graphite Handbook (1968)

Carbon and graphite handbook , Carbon and graphite handbook , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Photodynamic therapy: mechanism of action and ways to improve the efficiency of treatment. (2003)

Photodynamic therapy is treatment modality involving the administration of photosensitizing compound, which selectively accumulates in the hyperproliferative target cells followed by local irradiation with visible light of lesion. Eventually target tissue will be damaged by necrosis and apoptosis. Action of treatment is described from absorption of light till damage of tissue. Several rationale proposals to increase the efficiency of described treatment modality are suggested: to evaluate the antiproliferative activity of new coming photosensitizers, to combine photosensitization with other treatment modalities in molecular level, exploring mechanism of apoptosis, to increase the efficiency of treatment by combination with ionizing radiation, hyperthermia or ligation of peripheral benzodiazepine receptors.
Reverse Transcription-PCR Analysis of the Regulation of the Manganese Peroxidase Gene Family (1998)

Manganese peroxidase (MnP) gene expression in the lignin-degrading fungus Phanerochaete chrysosporium is regulated by nutrient nitrogen levels and by Mn(II), the substrate for the enzyme, as well as by heat shock and other factors. Reverse transcription-PCR (RT-PCR) of total RNA can distinguish the mRNAs of each of the three sequenced P. chrysosporium mnp genes, i.e., mnp1, mnp2, and mnp3. Quantitative RT-PCR demonstrates that each of the three transcripts is present at a similar low basal level in nitrogen-sufficient cultures, with or without Mn, and in nitrogen-limited cultures lacking Mn. However, in 5-day-old, nitrogen-limited, stationary cultures supplemented with 180 microM Mn, the levels of the mnp1 and mnp2 transcripts increased approximately 100- and 1,700-fold, respectively, over basal levels. In contrast, under these conditions, the level of the mnp3 transcript did not increase significantly over the basal level. Quantitative RT-PCR of total RNA extracted from nitrogen-deficient, Mn-supplemented cultures on days 2 through 7 demonstrates that whereas the mnp1 transcript was present at relatively low levels on days 3 through 7, the mnp2 transcript level peaked on day 5 and the mnp3 transcript level peaked on day 3. Comparison of total RNA extracted on day 5 from nitrogen-deficient, Mn-supplemented stationary and agitated cultures indicates that in stationary cultures, mnp2 was the major expressed mnp gene, whereas in large agitated cultures, mnp1 was the major expressed mnp gene.
Distributed Electronic Rights in JavaScript (2013)

Contracts enable mutually suspicious parties to cooperate safely through the exchange of rights. Smart contracts are programs whose behavior enforces the terms of the contract. This paper shows how such contracts can be specified elegantly and executed safely, given an appropriate distributed, secure, persistent, and ubiquitous computational fabric. JavaScript provides the ubiquity but must be significantly extended to deal with the other aspects. The first part of this paper is a progress report on our efforts to turn JavaScript into this fabric. To demonstrate the suitability of this design, we describe an escrow exchange contract implemented in 42 lines of JavaScript code.
Fully automated dissolution and separation methods for inductively coupled plasma atomic emission spectrometry rock analysis. Application to the determination of rare earth elements. Plenary lecture (1987)

In rock analysis laboratories, sample preparation is a serious problem, or even an enormous bottleneck. Because this laboratory is production-oriented, this problem was attacked by automating progressively, different steps in rock analysis for major, minor and trace elements. This effort has been considerably eased by the fact that all sample preparation schemes in this laboratory for the past three decades have been based on an initial lithium borate fusion of rock samples and all analytical methods based on multi-element atomic emission spectrometry, with switch-over from solid analysis by arc/spark excitation to solution analysis by plasma excitation in 1974. The sample preparation steps which have been automated are: weighing of samples and fluxes, lithium borate fusion, dissolution and dilution of fusion products and ion-exchange separation of difficult trace elements such as rare earth elements (REE). During 1985 and 1986, these different unit operations have been assembled together as peripheral units in the form of a workstation, called LabRobStation. A travelling robot is the master of LabRobStation, with all peripheral units at its reach in 10 m2 workspace. As an example of real application, the automated determination of REE, based on more than 8000 samples analysed during 1982 and 1986, is presented.