gebhart/patrepeval huggingface dataset:
Prediction of protein accessible surface areas by support vector regression (2004)

A novel support vector regression (SVR) approach is proposed to predict protein accessible surface areas (ASAs) from their primary structures. In this work, we predict the real values of ASA in squared angstroms for residues instead of relative solvent accessibility. Based on protein residues, the mean and median absolute errors are 26.0 A(2) and 18.87 A(2), respectively. The correlation coefficient between the predicted and observed ASAs is 0.66. Cysteine is the best predicted amino acid (mean absolute error is 13.8 A(2) and median absolute error is 8.37 A(2)), while arginine is the least predicted amino acid (mean absolute error is 42.7 A(2) and median absolute error is 36.31 A(2)). Our work suggests that the SVR approach can be directly applied to the ASA prediction where data preclassification has been used.
Cancer-preventing attributes of probiotics: an update (2010)

Cancer is a serious global public health problem. Cancer incidence and mortality have been steadily rising throughout the past century in most places of the world. There are several epidemiological evidences that support a protective role of probiotics against cancer. Lactic acid bacteria and their probioactive cellular substances exert many beneficial effects in the gastrointestinal tract, and also release various enzymes into the intestinal lumen and exert potential synergistic (LAB) effects on digestion and alleviate symptoms of intestinal malabsorption. Consumption of fermented dairy products with LAB may elicit anti-tumor effects. These effects are attributed to the inhibition of mutagenic activity, the decrease in several enzymes implicated in the generation of carcinogens, mutagens, or tumor-promoting agents, suppression of tumors, and epidemiology correlating dietary regimes and cancer. Specific cellular components in lactic acid bacteria seem to induce strong adjuvant effects including modulation of cell-mediated immune responses, activation of the reticulo-endothelial system, augmentation of cytokine pathways, and regulation of interleukins and tumor necrosis factors. Studies on the effect of probiotic consumption on cancer appear promising, since recent in vitro and in vivo studies have indicated that probiotic bacteria might reduce the risk, incidence and number of tumors of the colon, liver and bladder. The protective effect against cancer development may be ascribed to binding of mutagens by intestinal bacteria, may suppress the growth of bacteria that convert procarcinogens into carcinogens, thereby reducing the amount of carcinogens in the intestine, reduction of the enzymes beta-glucuronidase and beta-glucosidase and deconjugation of bile acids, or merely by enhancing the immune system of the host. There are isolated reports citing that administration of LAB results in increased activity of anti-oxidative enzymes or by modulating circulatory oxidative stress that protects cells against carcinogen-induced damage. These include glutathione-S-transferase, glutathione, glutathione reductase, glutathione peroxidase, superoxide dismutase and catalase. However, there is no direct experimental evidence for cancer suppression in human subjects as a result of the consumption of probiotic cultures in fermented or unfermented dairy products, but there is a wealth of indirect evidence based largely on laboratory studies.
An Ultra Compact and Broadband 15–75 GHz BPSK Modulator Using 0.13-µm CMOS Process (2005)

In this paper, an ultra compact and broadband 15-75 GHz BPSK modulator using standard bulk 0.13-µm CMOS process is described.This modulator was constructed utilizing a new reflection-type topology, with the transmission lines implemented on the thick SiO 2 layer as the substrate to avoid the lossy silicon.The overall chip size, including baseband, LO, and RF probe pads, is only 0.5 × 0.35 mm 2 .Compared with the previously reported GaAs modulators, this work demonstrates a more than 80% chip area reduction, and features an amplitude imbalance of within 0.5 dB with a phase imbalance of within 3° between 15 and 75 GHz.Regarding the modulation quality, the measured error vector magnitude (EVM) of the BPSK modulator at 40 GHz is within 3.5 and 7% for a data rate of 1 and 10 Mb/s, respectively.The LO-to-RF isolation is better than 40 dB among all the operation frequency.From continuouswave (CW) spectrum characterization, the modulation bandwidth of the modulator is wider than 1 GHz.
That "Barton Fink Feeling” and the Fiery Furnace: The Book of Daniel and Joel and Ethan Coen's Barton Fink (2008)

This paper explores the use of the Book of Daniel in Joel and Ethan Coen's Barton Fink. While some critics have noted the film's "apocalyptic” dimension, and have even mentioned the movie's two explicit mentions of the Daniel story, none has studied the close relationship between the biblical text and the film. This article argues that the Book of Daniel is central to the structure of Barton Fink, by arguing that the movie both presents the crisis of Barton's visionary attempt to deliver both a dream and its interpretation (Dan. 2:5), and offers an apocalyptic "cure” to correct his vision.
Isolation and characterization of two proteins copurifying with carcinoembryonic antigen. (1984)

Using common purification procedures CEA was eluted as a symmetrical peak after gel-chromatography with a molecular weight (mw) of 180,000. The purity was assessed by the Ouchterlony test and immunoelectrophoresis, and by SDS-PAGE, where only one precipitation line and one band were obtained. However, two weak bands with a mw of 45,000 and 58,000 appeared, when iodinated CEA preparations were analyzed on SDS-PAGE. It was impossible to separate these proteins from CEA by a great variety of purification procedures. Out of several different immune sera, only two, anti-alpha-antitrypsin and anti-alpha-1-antichymotrypsin, reacted with the proteins. Furthermore, antisera against these protease inhibitors also immunoprecipitated the typical 180,000 mw band of CEA. This was also true for CEA prepared by other laboratories. We have purified and partially characterized both proteins. Although reacting with antisera against alpha-1-antitrypsin and alpha-1-antichymotrypsin they were not identical to the protease inhibitors, because they possess a different N-terminal amino acid sequence than published for them. However, the comparison of their sequences to 1900 total protein sequences made by computer search revealed a strong homology of the N-terminal sequence of the 45,000 mw protein with an internal sequence of alpha-1-antitrypsin. For the 58,000 mw protein no significant homology was found.
CELSUS High Pressure Laminate (2011)

CELSUS is a high pressure laminate that eliminates the visibility of fingerprints.High pressure laminates consists of high-strength finishing materials used in household furnishings and wall surfaces.It has a clean,fresh look and feel. CELSUS provides living spaces where anyone can spend their time enjoyably.
Stereoselective pharmacokinetics of oral and intravenous nitrendipine in healthy male subjects. (1991)

1. Stereoselectivity in the pharmacokinetics of nitrendipine was investigated by reanalysing plasma samples of a previously published study (Soons et al., 1989). 2. Racemic nitrendipine was administered intravenously (40 micrograms kg‐1) and orally, both as plain tablet (20 mg) and in an osmotic pump device (40 mg Osmet) to nine healthy male subjects. Nitrendipine enantiomers were measured with a stereoselective assay. 3. Upon oral administration (tablet) the bioavailability of (S)‐ (−)−nitrendipine (13.4% +/‐ 5.6%) was 75% (50% ‐ 98%) higher than that of (R)‐nitrendipine (7.9% +/‐ 4.0%) (mean +/‐ s.d. (95% confidence interval)). Values of AUC and Cmax for (S)‐nitrendipine were 90% (55% ‐ 121%) and 77% (51% ‐ 100%) higher respectively, than those for (R)‐ nitrendipine. Similar results were obtained with the osmotic system. 4. The clearance of intravenously administered (S)‐nitrendipine was slightly (7%) lower than that of (R)‐nitrendipine, but elimination half‐ lives and volumes of distribution were similar. 5. The difference in disposition of nitrendipine enantiomers is most likely related to a difference in activity of the cytochrome P‐450 system towards the enantiomers, giving rise to a two‐fold difference in first‐pass elimination. 6. Stereoselectivity in the first pass metabolism of nitrendipine exhibited little intersubject variability and therefore is not a major factor in the wide variability in systemic availability of the more‐potent (S)‐enantiomer.
Compact ultra-wideband printed antenna with band-rejection characteristic (2005)

A novel and compact ultra-wideband printed antenna with band-rejection characteristic is proposed. By cutting an L-shaped notch on the radiating patch, the impedance bandwidth of the proposed antenna can be enhanced. In addition, a C-shaped slot is introduced to obtain the band-rejection operation of the antenna. The antenna, with compact size of 15.5×21 mm including the ground plane, operates over 3.08–10.97 GHz and has the rejected band from 5.03 to 5.91 GHz.
Nanostructure of Co/Cu multilayers (1991)

The nanostructure and local strain of [111] fcc Co/Cu multilayers are studied by means of nuclear magnetic resonance. The atomic topology of the interface can be deduced from the NMR spectrum and the local strains from the shift in the hyperfine fields. The results show that the Co/Cu interface is a mixed monolayer and that the Co layers, including the interface, have uniform strain inversely proportional to the Co thickness (within experimental error) with the proportionality constant depending on the Cu thickness.
Guard Ring Simulations for n-on-p Silicon Particle Detectors (2010)

We propose a new guard ring geometry for n-on-p silicon particle detectors for high luminosity applications. The performance of the guard ring structure is evaluated with simulations up to a radiation fluence of 1 x 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> n <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eq</sub> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> using an existing three level trap model for p-type FZ silicon. The post-irradiation performance improvement of guard rings with floating field plates pointing towards the sensitive region is demonstrated. The breakdown behavior of the guard ring structure is studied as a function of oxide charge, field plate length, and oxide thickness.
농촌지역활성화를 위한 기업의 지역사회투자활동과 중간지원조직의 역할: 농촌사랑국민운동본부의 1사1촌 운동을 사례로 (2011)

본 연구는 국내 대표적인 지역사회공헌프로그램인 1사1촌 자매결연 활동에 참여하고 있는 기업들을 대상으로 자매결연의 교류현황을 살펴보고, 1사1촌 자매결연활동을 주관하는 중간지원조직으로서의 농촌사랑국민운동본부의 기능을 평가하였다. 분석결과, 기업은 농촌 지역의 어려움을 인식하고 개선시키기 위한 목적으로 1사1촌 활동을 전개하고 있었으며, 일손돕기와 같은 단순교류 활동이나 농산물 직거래 활동이 주요 교류활동으로 나타났다. 농촌사랑국민운동본부의 역할에 대한평가는 자매결연 초기에 필요한 정보제공 및 중개기능이 높게 평가되었으며, 결연 이후 지속적인 참여를 유도하기 위한 네트워크 및 교류촉진 기능은 낮게 평가되었다. 향후 1사1촌 자매결연 운동이 보다 실질적인 지역사회투자활동으로서 발전하기 위해서는 농촌마을과 기업의 중개 및 중재기능을 보완하고 마을과 기업의 특성에 맞는 맞춤형 프로그램의 개발이 요구되는 바이다. 또한 기업 및 농산촌 마을 이해관계자들을 대상으로 협의회를 구축하고 학습 및 교류 기회를 제공하여 정보를 공유하고 네트워크를 구축할 수 있는 기회를 증진시켜야 할 것이다. 이밖에 농촌의 사회, 경제 문화, 환경의 다각적인 접근을 통해 농촌지역 문제를 해결할 수 있는 실용적인 솔루션을 개발하여 지역경제활성화 및 고용창출의 효과를 극대화시켜야 할 것이다.
Predicate Abstraction in Program Verification: Survey and Current Trends (2014)

A popular approach to verification of software system correctness is model checking. To achieve scalability needed for large systems, model checking has to be augmented with abstraction. In this paper, we provide an overview of selected techniques of program verification based on predicate abstraction. We focus on techniques that advanced the state-of-the-art in a significant way, including counterexample-guided abstraction refinement, lazy abstraction, and current trends in the form of extensions targeting, for example, data structures and multi-threading. We discuss limitations of these techniques and present our plans for addressing some of them.
Effects of Acylation and Crosslinking on the Material Properties and Cadmium Ion Adsorption Capacity of Porous Chitosan Beads (1995)

Abstract Chitosan is a novel glucosamine biopolymer derived from the shells of marine organisms. This biopolymer is very attractive for heavy metal ion separations from wastewater because it is selective for toxic transition metal ions over less toxic alkali or alkane earth metal ions. Highly porous, 3-mm chitosan beads were prepared by an aqueous phase-inversion technique for casting gel beads followed by freeze drying. In the attempt to simultaneously improve material properties and adsorption capacity, chitosan was chemically modified by 1) homogeneous acylation of amine groups with nonanoyl chloride before bead casting, and 2) heterogeneous crosslinking of linear chitosan chains with the bifunctional reagent glutaric dialdehyde (GA) after bead casting but before freeze drying. The random addition of C8 hydrocarbon side chains to about 7% of the amine groups on uncrosslinked chitosan beads via N-acylation improved the saturation adsorption capacity from 169 to 216 mg Cd2+/g-bead at saturation (pH 6.5, 25°C) but only slightly reduced solubility in acid solution. Crosslinking of the N-acylated chitosan beads with 0.125 to 2.5 wt% GA in the crosslinking bath increased the internal surface area from 40 to 224 m2/g and rendered the beads insoluble in 1 M acetic acid (pH 2.36). However, crosslinking of the N-acylated chitosan beads reduced the saturation adsorption capacity to 136 mg Cd2+/g-bead at 0.75 wt% GA and 86 mg Cd2+/g-bead at 2.5 wt% GA. Crosslinking also significantly reduced the compression strength. There was no clear relationship between internal surface area and adsorption capacity, suggesting that the adsorbed cadmium was not uniformly loaded into the bead.
On the application of the Neuron MOS transistor principle for modern VLSI design (1996)

In this paper, the speed performance, power consumption, and layout area of Neuron MOS transistor circuits are monitored considering the requirements of modern VLSI design. The Neuron MOS transistor is a recently discovered device principle which has a number of input gates that couple capacitively to a floating gate. The floating gate potential controls the current of a transistor channel. This device can be used in logic circuits. A threshold current through the Neuron MOS transistor can be defined that causes a switching of the output of the logic circuits as soon as the channel current surmounts or falls below the specified value. We designed two different multiplier cells, one based on a Neuron MOS inverter, and the other on a Neuron MOS n-MOSFET which is used as one input device of a comparator circuit. Functionality of both cells is proven for data rates up to 50 MHz which represents the first high-speed measurement of a circuit based on this new design principle. A perspective for the upper speed limit found at more than 500 MHz is given by simulation. The new design principle has a layout area reduced by more than a factor of two compared to usual multiplier cells. Moreover, it is shown, that depending on the design chosen, high speed operation leads to considerable power savings. In view of those advantages it is concluded that the principle of threshold logic qualifies for a major breakthrough for packing density improvement of CMOS-based applications.
Geometrical Optics-Based Model for Dielectric Constant and Loss Tangent Free-Space Measurement (2014)

A microwave free-space reflection method for determining the complex permittivity of planar dielectric materials is demonstrated. The method makes use of the measurement of the near-field microwave reflection coefficient of a metal-backed sample. The modeling of the structure and its calibration are based on geometrical optics considering spherical electromagnetic waves propagating through the material. The technique that presents a number of features such as low-cost, compactness, robustness, and reliability is a good candidate for industrial applications. As a demonstration, dielectric parameters extraction of building materials is experimentally demonstrated for wireless local area network operations in the 2.45- and 5-GHz bands.
A high-slew integrator for switched-capacitor circuits (1994)

A new method for improving the slew rate of a switched-capacitor integrator is introduced. A booster circuit is used to measure the integrator input voltage and then inject a proportionate amount of charge at the integrator output. The boosted integrator significantly reduces the settling time due to amplifier slewing. In addition, the booster has no adverse effect on the noise and stability performance of the integrator. The booster stage increases the total static integrator power by 36% and the total die area by 22%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer. (2013)

Quantification of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression seems to provide valuable prognostic information in CRC and the correlation with clinicopathological data revealed an association with characteristics that contribute to progression, invasion and metastasis leading to poorer survival rates and prognosis.
Learning membership functions from examples (2002)

Describes the adaptation of a crisp induction algorithm, called constrained generalization, to the building of fuzzy rules. This approach bridges the gap between machine learning and fuzzy logic. An application is learning membership functions from examples, as well as estimating a real-valued attribute. By means of membership functions, measurable information is possibly correctly translated within linguistic qualifiers. The acceptance of linguistic qualifiers is generally context-dependent. Therefore, a method for automatically designing membership functions from examples is presented. This method, inspired by supervised learning, also applies when the target concept depends on several attributes. It then builds fuzzy rules. The approach is validated on a real-world problem, predicting the elastic limit of new materials from a database about trials on composite materials.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A preliminary study on atrial epicardial mapping signals based on Graph Theory (2014)

In order to get a better understanding of atrial fibrillation, we introduced a method based on Graph Theory to interpret the relations of different parts of the atria. Atrial electrograms under sinus rhythm and atrial fibrillation were collected from eight living mongrel dogs with cholinergic AF model. These epicardial signals were acquired from 95 unipolar electrodes attached to the surface of the atria and four pulmonary veins. Then, we analyzed the electrode correlations using Graph Theory. The topology, the connectivity and the parameters of graphs during different rhythms were studied. Our results showed that the connectivity of graphs varied from sinus rhythm to atrial fibrillation and there were parameter gradients in various parts of the atria. The results provide spatial insight into the interaction between different parts of the atria and the method may have its potential for studying atrial fibrillation.
Vagus nerve participates in regulation of the airways: inflammatory response and hyperreactivity induced by occupational asthmogens. (2004)

An initial recognition of occupational asthmogens present in dust, fume or aerosol particles is carried out by a specialized subset of immune cells, dendritic cells and macrophages, present in the airway tissues. When activated by asthmogens these cells release proinflammatory molecular signals and not only send them to other cells of the innate immunological system, but also activate sensory pathways that relay information to the central nervous system (CNS). The precise mechanisms by which the peripheral immune system can signal to the CNS the airway injury has been the subject of much debate. Recently, a new pathway of the CNS-mediated regulation of the peripheral immune response has been found. The efferent vagus nerve was proposed as an immune-to-brain pathway and it was suggested that acetycholine, the principal vagal neurotransmitter, may directly modulate the airway immune response to pathogenic invasion or to injury by irritant asthmogens. Sensory innervation of the airways by ascending fibres traveling in the vagus nerve as well as by pain sensory pathways, provides an important input about the status of injurious challenges in the inflammation zone of the airway compartments. These neural inflammation-sensing pathways can function at low thresholds of detection and can activate responses even when inflammatory agents are present in the airway tissues in quantities that are not high enough to reach the brain through the bloodstream. The cholinergic vagus nerves participate not only in the regulation of the airways inflammatory response. The airways function in response to spastic stimuli such as irritants, allergens, and inflammatory mediators is also controlled, in a larger part, by efferent vagal endings present in the airway smooth muscles. Cholinergic mechanisms represent the predominat constrictor neural pathway in human airways. Differences in expression of muscarinic acetylcholine receptors in asthma suggest that cholinergic system may participate in the molecular framework influencing the airway functions in occupational asthma.
Non-Pegylated Liposomal Doxorubicin in Combination with Cyclophosphamide or Docetaxel as First-Line Therapy in Metastatic Breast Cancer: A Retrospective Analysis (2009)

Our results support the use of non-pegylated liposomal doxorubicin as an alternative to conventional doxorubicin formulations in combination regimens for the first-line therapy of metastatic breast cancer.
DVB-T2 versus DVB-T what has been changed and why? (2008)

The new DVB's standard proposal of digital terrestrial television DVB-T2 has been briefly characterized. Comparison between the new and the current DVB-T standard has been presented.
Genes affecting phenotypic plasticity in <i>Arabidopsis</i>: pleiotropic effects and reproductive fitness of photomorphogenic mutants (1999)

Abstract Many plants exhibit characteristic photomorphogenic shade ’avoidance’ responses to crowding and vegetation shade; this plasticity is often hypothesized to be adaptive. We examined the contribution of specific photomorphogenic loci to plastic shade avoidance responses in the annual crucifer Arabidopsis thaliana by comparing single-gene mutants defective at those loci with wild type plants exhibiting normal photomorphogenesis. The hy1 and hy2 mutants, deficient in all functional phytochromes, were less plastic than the wild type in response to a nearby grass canopy or to a low-red/far-red light ratio characteristic of vegetation shade. These mutants displayed constitutively shade-avoiding phenotypes throughout the life cycle regardless of the treatment: they bolted at an earlier developmental stage and were characterized by reduced branching. In contrast, the hy4 mutant, deficient in blue light reception, exhibited greater plasticity than the wild type in response to vegetation shade after the seedling stage. This mutant produced more leaves before bolting and more basal branches under normal light conditions when compared to the wild type. These results indicate that specific photomorphogenic loci have different and sometimes antagonistic pleiotropic effects on the plastic response to vegetation shade throughout the life cycle of the plant. The fitness of the constitutively shade-avoiding phytochrome-deficient mutants was lower than that of the plastic wild type under normal light, but was not different in the vegetation shade treatments, where all genotypes converged toward similar shade avoidance phenotypes. This outcome supports one key prediction of the adaptive plasticity hypothesis: that inappropriate expression of shade avoidance traits is maladaptive.