gebhart/patrepeval huggingface dataset:
Surfaceome Profiling Reveals Regulators of Neural Stem Cell Function (2013)

The composition of cell-surface proteins changes during lineage specification, altering cellular responses to their milieu. The changes that characterize maturation of early neural stem cells (NSCs) remain poorly understood. Here we use mass spectrometry-based cell surface capture technology to profile the cell surface of early NSCs and demonstrate functional requirements for several enriched molecules. Primitive NSCs arise from embryonic stem cells upon removal of Transforming growth factor-β signaling, while definitive NSCs arise from primitive NSCs upon Lif removal and FGF addition. In vivo aggregation assays revealed that N-cadherin upregulation is sufficient for the initial exclusion of definitive NSCs from pluripotent ectoderm, while c-kit signaling limits progeny of primitive NSCs. Furthermore, we implicate EphA4 in primitive NSC survival signaling and Erbb2 as being required for NSC proliferation. This work elucidates several key mediators of NSC function whose relevance is confirmed on forebrain-derived populations and identifies a host of other candidates that may regulate NSCs.
Modeling and Motor Learning of Reaching Movements in Virtual Environments (2007)

The paper presents an analysis of human reaching movements in manipulation of flexible objects. To predict the trajectory of human hand we resort to two models, the lowest polynomial order model for the hand movement and the minimum hand jerk model. First, we derive analytical solutions for these models for the dynamic environment represented by a multi-mass linear flexible object. Then, we present initial experimental results. It is shown that the lowest polynomial order model does not fit with the experimental data while the prediction by the minimum hand jerk criterion matches the experimental patterns with reasonable accuracy.
ChemInform Abstract: TRANSITION METAL CARBYNE COMPLEXES, XXVII. DICARBONYL(Π‐CYCLOPENTADIENYL)CARBYNE COMPLEXES OF TUNGSTEN (1977)

Abstract Die Bromocarbinkomplexe (I) reagieren mit Cyclopentadienylnatrium unter Ersatz des Halogenliganden und zusätzlicher Abspaltung zweier CO‐Gruppen zu den z.T. bereits beschriebenen Komplexen (II).
Photothermal images of live cells in presence of drug (2002)

A new method for the study of drug-cell interaction is suggested. It is based on optical monitoring of cell response to drug impact. To detect this response, a high sensitive photothermal imaging technique has been developed. This technique is based on irradiation of the cells with a focused short pulse double-frequency pump laser (532 nm, 8 ns) and monitoring the laser-induced local thermal effects. This is realized with a second collinear dye laser pulse (630 nm, 6 ns) that probes the heated cell absorbing zones. The temperature-dependent variations of the refractive index in the absorbing zones in cross section of probe beam are recorded with phase-contrast technique. The photothermal (PT) image represents a two-dimensional depth-integrated temperature distribution in the irradiated volume and correlates with the conventional optical absorption images. It was experimentally shown that the introduction of NaN(3) or anti-tumor drug in the cell suspension led to a change in the structure of PT images of human lymphocytes and human lympholeukemia cells, respectively. It was hypothesized that the observed effects could be associated with the change of redox state of respiratory chain component.
Genetics of schizophrenia: implications for treatment (2004)

Schizophrenia is a common, debilitating illness for which treatment is empirical and unsatisfactory. Intense efforts to identify etiological factors have been launched in order to facilitate rational therapy. Such efforts have included gene-mapping studies since a significant heritability has been proved. In common with other polygenic/multifactorial disorders, mapping efforts for schizophrenia pose daunting challenges. Faced with such complexities, attempts to detect genetic associations with pharmacological response have been initiated. Although intriguing associations have been reported, formal replication is required. Suggestions for the design of replicate studies are proposed. This review is restricted to studies that investigated response to clozapine (Clozaril, Novartis) and other novel antipsychotic medications.
The speed limit for protein folding measured by triplet–triplet energy transfer (1999)

A direct measure of intramolecular chain diffusion is obtained by the determination of triplet-triplet energy-transfer rates between a donor and an acceptor chromophore attached at defined points on a polypeptide chain. Single exponential kinetics of contact formation are observed on the nanosecond time scale for polypeptides in which donor and acceptor are linked by repeating units of glycine and serine residues. The rates depend on the number of peptide bonds (N) separating donor and acceptor and show a maximum for the shortest peptides (N = 3) with a time constant (tau = 1/k) of 20 ns. This sets an upper limit for the speed of formation of the first side-chain contacts during protein folding.
A supramolecular assembly of a multifunctional calix[4]arene with alkali and alkaline earth cations in solution and in the solid state (1996)

Abstract p-tert-Butylcalix[4]arene derivatives 2 and 4 bearing one carboxy-lic acid, one ester and two phenolic groups on the lower rim form pH-dependent mononuclear or binuclear assemblies with alkali (excluding lithium) and alkaline earth cations. The structures of binuclear K+ complexes 5 and 6 of 2 and 4, respectively, have been determined by X-ray diffraction.
Phosphoproteomic profiling of pediatric B-ALL patients with MLL rearrangements (2008)

10001 Background: While the outcome for children with Acute Lymphoblastic Leukemia (ALL) has improved under current therapies, 30% do not have a favourable outcome. Infants with MLL rearrangements form the most striking example of ALL patients who have not benefited from the improved treatment regimens developed over recent decades. Our study aims to better map the biology of the MLL disease and to identify aberrantly activated phosphoproteins specific for MLL rearranged patients using phosphoproteomic measurement of signal transduction pathways (STPs). This will offer possibilities to identify new drug targets for more effective and less toxic targeted therapies. Methods: Reverse Phase Protein Arrays (RPPA) were employed to profile the working state of cellular STPs in 120 pediatric B-ALL specimens collected prior to treatment. The phosphorylation status of 92 key signalling proteins was analyzed. We compared 9 MLL rearranged patients vs 42 patients without known genomic aberrancies to find differentially activated phosphoproteins. Based on the results of the RPPA analysis, we then tested the effects of a specific inhibitor on the survival of two human cell lines: RS4;11 (MLL B-ALL with t(4;11)) and REH (B-ALL with t(12;21)). Results: MLL rearranged patients show an activated pathway that, through the phosphorylation of AMPK, leads to the activation of eNOSIII and finally Bcl-2. Bcl-2 is an antiapoptotic protein which may provide survival advantage to the blast cells. We treated RS4;11 and REH cells with an AMPK inhibitor (6μM, 24hours). After treatment, we observed that treated RS4;11 cells undergo significantly more apoptosis than REH cells (p<0.001). For RS4;11 cells only 31.1% of cells remained alive after treatment, while 89.3% of the REH cells were insensitive to treatment. Conclusions: The activation of the AMPK pathway may contribute to the survival of MLL leukaemia cells, since inhibition of AMPK induces death in these cancer cells. Our data strongly encourage further studies of AMPK inhibitors as potential new drugs for the treatment of MLL leukaemia patients. The discovery of the molecular signal pathway portrait in subgroups of patients could play an important role for individualizing therapy and improving treatment outcome. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Theranostics Health LLC Theranostics Health LLC
NMR Investigation of the Interactions between 4‘-Fluoro-1‘-acetonaphthone and the Suwannee River Fulvic Acid (1999)

The association of 4‘-fluoro-1‘-acetonaphthone (F-acetonaphthone) with the International Humic Substances Society (I.H.S.S.) Suwannee River fulvic acid (SRFA) standard in 55% CH3OD/45% D2O was investigated as a function of SRFA concentration (4.5−13.5 mg/mL) as well as solution pαH* (3.88−7.56). 19F NMR measurements of T1 and T2 relaxation times were used in conjunction with chemical shift and diffusion coefficient measurements to study the interaction, and the results were interpreted using the current association models reported in the literature (1). Analysis of diffusion coefficients measured as a function of SRFA concentration suggests that a small amount of the F-acetonaphthone is associated with SRFA. Unusual behavior of the T1 and T2 relaxation time constants, correlation times calculated from these parameters, and diffusion coefficients were observed for F-acetonaphthone in solutions of SRFA in 55% CH3OD/45% D2O at pαH* 6.10. Analysis of the pαH* dependence of the diffusion coefficients suggests two competing mechanisms of association between F-acetonaphthone and SRFA, hydrophobic interactions, and hydrogen bonding. The contribution of the fluorine label to the interaction of F-acetonaphthone with SRFA was investigated using 19F NOE measurements as well as measurements of competitive binding by unfluorinated acetonaphthone and fluorobenzene.
ChemInform Abstract: PRACTICAL SYNTHESIS OF 3,3,4,4‐TETRAMETHYLCYCLOPENTANONE (1984)

Abstract Aus Isobuttersäuremethylester (I) wird durch Umsetzung mit Lithiumdiisopropylamid und 2,3‐Dichlorpropen (II) der Ester (III) hergestellt, aus dem mit Methyllithium das Carbinol (IV) erhalten wird.
Dobutamine in the rejecting transplanted heart (1981)

Dopamine is commonly used to improve cardiac output and to maintain peripheral perfusion after myocardial injury. It has several advantages over other catecholamines. At effective inotropic dose levels, dopamine produces less peripheral vasoconstriction than norepinephrine. Dopamine also causes fewer arrhythmias than isoproterenol. This is a case report of a heart transplant patient who began rejecting and developed heart failure. In addition to the immunosuppressive agents, dopamine was used initially as the vasopressor with marked deterioration in the patient's condition. Dobutamine, a new inotropic agent, was substituted for dopamine with subsequent improvement in cardiac function. The authors concluded that dobutamine may be the most appropriate agent to use in the rejecting transplanted heart because of the former's direct action on the heart. Dobutamine may also be preferred for support of the cardiac outputs of patients with chronic heart failure.
Electrically injected InP microdisk lasers integrated with nanophotonic SOI circuits (2008)

We have achieved continuous-wave electrically-injected lasing operation at room-temperature in InP-based microdisks heterogeneously integrated on a SOI nanophotonic circuit. The microdisks were evanescently coupled with sub-micron SOI wire waveguides, resulting in up to 10 μW waveguide-coupled unidirectional output power, with a measured slope efficiency up to 20 μW/mA. A tunnel junction was used for efficient electrical injection with low optical absorption. The measured laser performance agrees well with calculations based on a standard laser model. This model suggests that considerable improvement in laser performance is possible.
Different Fine Binding Specificities of Monoclonal Antibodies to Disialosylganglioside GD21 (1988)

The fine structural specificities of six monoclonal antibodies (MAbs) to ganglioside GD2, GalNAc beta 1----4(NeuAc alpha 2----8NeuAc alpha 2----3)Gal beta 1----4Glc-Cer, were studied. The binding specificities of these MAbs were found to differ from each other by virtue of their binding to structurally related authentic standard glycolipids as revealed by three different assay systems, including enzyme immunostaining on thin-layer chromatography, enzyme-linked immunosorbent assay, and immune adherence inhibition assay. The MAbs examined could be divided into three binding types. MAbs A1-201, A1-410, and A1-425 bound specifically to ganglioside GD2 and none of the other gangliosides tested. Two other MAbs (A1-245 and A1-267) reacted not only with GD2, but also with several other gangliosides having the sequence NeuAc alpha 2----8NeuAc alpha 2----3Gal (GD3, GD1b, GT1a, GT1b, and GQ1b). The reactivities with these gangliosides varied to some degree. In addition, these MAbs were found to react with both GD3(NeuAc-NeuAc) and GD3(NeuGc-NeuAc), but not with GD3(NeuAc-NeuGc) or GD3(NeuGc-NeuGc). The last MAb (A1-287) also reacted with several other gangliosides but with lower avidity than A1-245 and A1-267. These findings suggest that each MAb to ganglioside GD2 may have an individual binding specificity and avidity. These MAbs represent potentially useful reagents for analyzing the function of GD2 on cell surface membranes, and provide a system for precisely studying the interactions between an anti-ganglioside antibody and the binding epitope of the antigenic determinant.
Development program on pressurized fluidized-bed combustion. Progress report, 1 July 1974--1 October 1974. [Burning coal in fluidized bed of particulate lime solids that react with S compounds formed during combustion to reduce air pollution; N oxides also reduced] (1974)

None
The Influence of Environment on Antigen Production by Pasteurella pestis Studied by Means of the Continuous Flow Culture Technique (1961)

SUMMARY: The yields of three antigens of Pasteurella pestis (fraction I, antigen 4, V antigen) in continuous flow culture over a range of temperature and pH values have been determined quantitatively. The production of some other antigens was followed qualitatively. The production of fraction I, V antigen and antigen 4 was greatest at 37° and little or none at 28°. The production of antigen 4 required an environmental pH below 6·9. The production of antigen 5 showed oxygen dependence at 28° but not at 37°. In transitions from one antigenic state to another the amounts of some antigens in the organism passed through maxima. Selection against types with the V and fraction I antigens occurred during growth at 37°, but not at 28°. Selection against types with antigen 4 did not occur.
ECG variation with R-R interval and with time-since breath in quiet subjects (2002)

In continuous 10-min recordings of lead II electrocardiogram (ECG) signals of two quiet seated subjects, variations of the ECG waveforms as a function of R-R interval and as a function of time sinc breath (breath interval) were examined. It was found that waveform measures such as QRS area and Q-R slope vary significantly as a function of breath interval. The R-T interval did not vary significantly with breath interval but did vary with R-R interval. The variation is less pronounced in quiet subjects than that which would be predicted from the Bazett equation for normalization of Q-T intervals by R-R intervals in general clinical use.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: ASYMMETRIC SYNTHESIS CATALYZED BY CHIRAL FERROCENYLPHOSPHINE‐TRANSITION METAL COMPLEXES. I. PREPARATION OF CHIRAL FERROCENYLPHOSPHINES (1980)

Abstract Da chirale Liganden in Übergangsmetallkomplexen asymm. Reaktionen katalysieren, werden verschiedene Arten chiraler Ferrocenylphosphine, die bedingt durch eine 1,2‐unsymm.
Energy Levels, Atom Populations, Bond Populations in the LCAO MO Model and in the FE MO Model. A Quantitative Analysis (1958)

Quantitative results for fourteen representative organic molecules are derived and analyzed on the basis of the LCAO MO model and on the basis of the FE MO model. Calculated are, besides the energy levels, the atom populations and the bond populations, quantities defined in a recent paper as an accurate measure of the distribution of electrons. The results of the LCAO MO model and of the FE MO model are then compared, and for the more important quantities considerable agreement is found. The origin of the agreements and disagreements is shown to be different from the one generally supposed. Because of their general usefulness, complete tables are given for the eigenvalues and eige nvectors of the fundamental topological matrices associated with the molecules investigated.
Zur Reaktion von PtF<sub>4</sub> mit Wasser und mit Methanol (1969)

Abstract Es wird über Fluorohydroxo‐ und Fluoromethoxoplatinate (IV) berichtet. Folgende Verbindungen wurden gewonnen und charakterisiert: H 2 [PtF 2 (OH) 4 ], M 2 [PtF 2 (OH) 4 ] (M = K, Na), K[PtF 2 (OCH 3 ) 3 H 2 O], M 2 [PtF 5 OCH 3 ] (M = K, Na, NH 4 ). Außerdem wurden die Hexafluoroplatinate mit den Kationen [N(CH 3 ) 4 ] + , [N(C 2 H 5 ) 4 ] + , [N(C 4 H 9 ) 4 ] + und [pyH] + erhalten. Chromatographisch wahrscheinlich gemacht wurden die Anionen [PtF 5 OH] 2− und [PtF 4 (OH) 2 ] 2− . Bei den Reaktionen entstanden weiterhin die Verbindungen PtF 2 (OCH 3 ) 2 und Pt(OCH 3 ) 4 . Beide Verbindungen sind sehr explosive Substanzen. Pt(OCH 3 ) 4 zersetzt sich bei vorsichtigem Erwärmen langsam; seine methanolische Lösung eignet sich zur Herstellung von Pt‐Überzügen auf Glas oder anderen Materialien.
Nanotribological Properties of UHMWPE/Quartz Composites (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Anomalous Eu layer doping in Eu, Si co-doped aluminium nitride based phosphor and its direct observation (2010)

Eu, Si co-doped AlN shows blue luminescence by UV and electron excitation. However, it is not clear how Eu is located in a wurtzite AlN lattice as there is not enough space for a large Eu cation. In the present study, Eu, Si co-doped AlN is analyzed to elucidate the luminescent Eu center’s location and the role of co-dopant Si. The XRD shows that the lattice parameters decrease compared to Eu solely doped AlN and undoped AlN due to Si doping in the AlN lattice. The Eu solely doped product shows impurity phase contamination with a reddish body color. Si co-doping is essential for Eu incorporation into AlN. TEM-EDS and HAADF-STEM measurements clarify that Eu forms a single layer structure with the Si condensation between the AlN wurtzite blocks. Another Si layer condensation is observed at the half position between Eu layers. Electron diffraction shows that there is no apparent long range ordering of Eu layer. The XAFS study shows that all the Eu in the product has a divalent valence and that the bond distance to the first neighboring anion is long at 0.315(8) nm. This is in good agreement with the model structure and the blue emission property. This result indicates that layer type doping can be a used to design new phosphors.
The social Robotplatform Probo (2010)

The past four years a unique robot platform 'Probo' is developed to study cognitive Human-Robot Interaction (HRI). The robot Probo (Saldien, 2009) is designed to act as a social interface, providing a natural interaction while employing human-like social cues and communication modalities. The robot has a fully actuated head, with 20 degrees of freedom, capable of showing facial expressions. Probo embodies a stuffed imaginary animal, providing a soft touch and a huggable appearance. A Robot Control Centre (RCC) enables the operator to control the robot in shared autonomy with the cognitive control of the robot. These cognitive control systems include the simulation of attention, homeostasis, emotional state and the generation of lifelike motions. This project aims to study HRI and Robotic Assisted Therapy (RAT) with a special focus on hospitalized children, a field with growing attention in the robotics community.
Improving Economics of Production in Heterogeneous Reservoirs by Redirecting Water Injection Patterns (2000)

Abstract Heterogeneous reservoirs undergoing waterflooding contain low-permeability zones in which oil in the low-permeability zones is bypassed by water. Profitability of producing from heterogeneous reservoirs can be poor because of premature water-breakthrough through high-permeability layers. It seems possible to improve the profitability of producing from heterogeneous reservoirs by diverting the injected water from preferentially flowing through high to low-permeability zones. The profitability improves because of a small increase in ultimate oil recovery and/or a large reduction in cumulative water production. The objective of this study is to investigate the applicability of the technology, referred to as indirect waterflooding, in different types of heterogeneous reservoirs. We performed numerical simulations of waterfloods on a generic five-spot pattern for three different reservoir cases. The reservoirs had properties typical of a San Andres Formation. The first case, with vertical-heterogeneity, showed that ultimate oil recovery might be improved by up to 13% OOIP with indirect waterflooding. The second case, with areal-heterogeneity and a low kv/kh, showed that water production might be reduced by as much as 27%. The third case, with areal heterogeneity and a zero kv/kh, showed that water production might be reduced by 31%. Actual recoveries are sensitive to reservoir properties, especially in the magnitude of the vertical permeability.
An Operando View of the Nanoscale (2015)

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTAn Operando View of the NanoscaleJohn R. Morris†, John N. Russell, Jr.‡, and Christopher J. Karwacki*§View Author Information† Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States‡ Chemistry Division, Naval Research Laboratory, Washington, District of Columbia 20375, United States§ Protection and Decontamination Division, U.S. Army, Edgewood Chemical Biological Center, Aberdeen Proving Ground, Aberdeen, Maryland 21010, United States*E-mail: [email protected]Cite this: J. Phys. Chem. Lett. 2015, 6, 24, 4923–4926Publication Date (Web):December 17, 2015Publication History Published online17 December 2015Published inissue 17 December 2015https://pubs.acs.org/doi/10.1021/acs.jpclett.5b02330https://doi.org/10.1021/acs.jpclett.5b02330editorialACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1451Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (363 KB) Get e-AlertscloseSUBJECTS:Catalysts,Nanoparticles,Nanoscale,Oxides,Ultrahigh vacuum Get e-Alerts