gebhart/patrepeval huggingface dataset:
Development of a Boundary Layer Properties Interpolation Tool in Support of Orbiter Return to Flight (2006)

A new tool was developed to predict the boundary layer quantities required by several physics-based predictive/analytic methods that assess damaged Orbiter tile. This new tool, the Boundary Layer Property Prediction (BLPROP) tool, supplies boundary layer values used in correlations that determine boundary layer transition onset and surface heating-rate augmentation/attenuation factors inside tile gouges (i.e. cavities). BLPROP interpolates through a database of computed solutions and provides boundary layer and wall data (delta, theta, Re(sub theta)/M(sub e), Re(sub theta)/M(sub e), Re(sub theta), P(sub w), and q(sub w)) based on user input surface location and free stream conditions. Surface locations are limited to the Orbiter s windward surface. Constructed using predictions from an inviscid w/boundary-layer method and benchmark viscous CFD, the computed database covers the hypersonic continuum flight regime based on two reference flight trajectories. First-order one-dimensional Lagrange interpolation accounts for Mach number and angle-of-attack variations, whereas non-dimensional normalization accounts for differences between the reference and input Reynolds number. Employing the same computational methods used to construct the database, solutions at other trajectory points taken from previous STS flights were computed: these results validate the BLPROP algorithm. Percentage differences between interpolated and computed values are presented and are used to establish the level of uncertainty of the new tool.
Personalized Search (2015)

As the volume of electronically available information grows, relevant items become harder to find. This work presents an approach to personalizing search results in scientific publication databases. This work focuses on re-ranking search results from existing search engines like Solr or ElasticSearch. This work also includes the development of Obelix, a new recommendation system used to re-rank search results. The project was proposed and performed at CERN, using the scientific publications available on the CERN Document Server (CDS). This work experiments with re-ranking using offline and online evaluation of users and documents in CDS. The experiments conclude that the personalized search result outperform both latest first and word similarity in terms of click position in the search result for global search in CDS.
Anaerobic Cometabolic Conversion of Benzothiophene by a Sulfate-Reducing Enrichment Culture and in a Tar-Oil-Contaminated Aquifer (2001)

Anaerobic cometabolic conversion of benzothiophene was studied with a sulfate-reducing enrichment culture growing with naphthalene as the sole source of carbon and energy. The sulfate-reducing bacteria were not able to grow with benzothiophene as the primary substrate. Metabolite analysis was performed with culture supernatants obtained by cometabolization experiments and revealed the formation of three isomeric carboxybenzothiophenes. Two isomers were identified as 2-carboxybenzothiophene and 5-carboxybenzothiophene. In some experiments, further reduced dihydrocarboxybenzothiophene was identified. No other products of benzothiophene degradation could be determined. In isotope-labeling experiments with a [(13)C]bicarbonate-buffered culture medium, carboxybenzothiophenes which were significantly enriched in the (13)C content of the carboxyl group were formed, indicating the addition of a C(1) unit from bicarbonate to benzothiophene as the initial activation reaction. This finding was consistent with the results of earlier studies on anaerobic naphthalene degradation with the same culture, and we therefore propose that benzothiophene was cometabolically converted by the same enzyme system. Groundwater analyses of the tar-oil-contaminated aquifer from which the naphthalene-degrading enrichment culture was isolated exhibited the same carboxybenzothiophene isomers as the culture supernatants. In addition, the benzothiophene degradation products, in particular, dihydrocarboxybenzothiophene, were significantly enriched in the contaminated groundwater to concentrations almost the same as those of the parent compound, benzothiophene. The identification of identical metabolites of benzothiophene conversion in the sulfate-reducing enrichment culture and in the contaminated aquifer indicated that the same enzymatic reactions were responsible for the conversion of benzothiophene in situ.
Future prospects for antiviral agents and new approaches (1984)

Journal Article Future prospects for antiviral agents and new approaches Get access George J. Galasso George J. Galasso National Institutes of HealthBethesda, Maryland, U.S.A Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 14, Issue suppl_A, 1984, Pages 127–136, https://doi.org/10.1093/jac/14.suppl_A.127 Published: 01 March 1984
Separated covariance filtering (1990)

A separated covariance filter (SCF) for estimating position and velocity given noisy measurements is discussed. The SCF calculates the state errors due to measurement errors and those due to target acceleration separately. The SCF overcomes two difficulties with the standard Kalman filter technique: (1) selection of the process noise covariance; and (2) interpreting the Kalman state covariance. The SCF is adaptable to a stream of unsequenced measurements. >
Borrelia burgdorferi swims with a planar waveform similar to that of eukaryotic flagella. (1994)

Borrelia burgdorferi is a motile spirochete with multiple internal periplasmic flagella (PFs) attached near each end of the cell cylinder; these PFs overlap in the cell center. We analyzed the shape and motion of wild type and PF-deficient mutants using both photomicrography and video microscopy. We found that swimming cells resembled the dynamic movements of eukaryotic flagella. In contrast to helically shaped spirochetes, which propagate spiral waves, translating B. burgdorferi swam with a planar waveform with occasional axial twists; waves had a peak-to-peak amplitude of 0.85 micron and a wavelength of 3.19 microns. Planar waves began full-sized at the anterior end and propagated toward the back end of the cell. Concomitantly, these waves gyrated counter-clockwise as viewed from the posterior end along the cell axis. In nontranslating cells, wave propagation ceased. Either the waveform of nontranslating cells resembled the translating form, or the cells became markedly contorted. Cells of the PF-deficient mutant isolated by Sadziene et al. [Sadziene, A., Thomas, D. D., Bundoc, V. G., Holt, S. C. & Barbour, A. G. (1991) J. Clin. Invest. 88, 82-92] were found to be relatively straight. The results suggest that the shape of B. burgdorferi is dictated by interactions between the cell body and the PFs. In addition, the PFs from opposite ends of the cell are believed to interact with one another so that during the markedly distorted nontranslational form, the PFs from opposite ends rotate in opposing directions around one another, causing the cell to bend.
Interspecies communication in <i>Streptococcus gordonii–Veillonella atypica</i> biofilms: Signaling in flow conditions requires juxtaposition (2004)

During the development of human oral biofilm communities, the spatial arrangement of the bacteria is thought to be driven by metabolic interactions between them. Streptococcus gordonii and Veillonella atypica, two early colonizing members of the dental plaque biofilm, have been postulated to participate in metabolic communication; S. gordonii ferments carbohydrates to form lactic acid, which is a preferred fermentation substrate for V. atypica. We found that, during agar-plate coculture of these organisms, a signaling event occurs that results in increased expression of the S. gordonii alpha-amylase-encoding gene amyB. Confocal scanning laser microscopy of coculture flowcell-grown biofilms using human saliva as the sole nutrient showed that V. atypica caused S. gordonii to increase expression of a PamyB-'gfp transcriptional fusion in a spatially resolved fashion. In this open system, only those streptococci in mixed-species microcolonies containing V. atypica expressed GFP; nearby S. gordonii colonies that lacked V. atypica did not express GFP. In a closed system containing S. gordonii and V. atypica, flow cytometric analysis showed that S. gordonii containing the PamyB-'gfp reporter plasmid exhibited mean fluorescence levels 20-fold higher than did S. gordonii that had not been incubated with V. atypica. Thus, in a closed system where a diffusible signal can accumulate above a required threshold, interspecies signaling mediates a change in gene expression. We provide evidence that, in open systems like those that predominate in natural biofilms, diffusible signals between species are designed to function over short distances, on the order of 1 mum.
Force-sensitive resistor of carbon-filled liquid silicone rubber (1996)

The effects of carbon content, tensile force, and temperature on the electrical resistance of carbon-filled liquid silicone rubber composites are studied. The relaxation process of resistance following loading can be described by an exponential function. The force dependence of the equilibrium resistance can be expressed by a second order polynomial, and such a relationship can be derived from the quantum mechanical tunneling conduction mechanism by assuming that the separation distance between carbon aggregates changes as a function of the tensile force with a form of Δw=kF2. Combining with the experimental data and typical values of theoretical parameters, the elastic modulus, the separation distance, and the proportional constant k can be obtained. Finally, the temperature dependence of resistance can be interpreted by the general form of R=R0 exp(const./T) with two different constants at different temperature ranges.
Application of multilocus sequence analysis (MLSA) for rapid identification of Enterococcus species based on rpoA and pheS genes (2005)

The aim of this study was to evaluate the use of RNA polymerase alpha subunit (rpoA) and phenylalanyl-tRNA synthase (pheS) gene sequences as species identification tools for enterococci. Ninety-six representative strains comprising all currently recognized Enterococcus species were examined. rpoA gene sequences generated a robust classification into species groups similar to the one based on 16S rRNA gene sequence analysis. On the other hand, the pheS gene is a fast-evolving clock even better suited for species delineation than the rpoA gene, but not for recognition of species groups within Enterococcus as determined by both rpoA and 16S rRNA genes. All enterococcal species were clearly differentiated on the basis of their rpoA and pheS sequences. Evaluation of intraspecies variation showed that both rpoA and pheS genes have a high degree of homogeneity among strains of the same species. Strains of the same enterococcal species have at least 99% rpoA and 97% pheS gene sequence similarity, whereas, different enterococcal species have at maximum 97% rpoA and 86% pheS gene sequence similarity. It was concluded that both genes can be used as reliable tools for identification of clinical and environmental species of Enterococcus and are efficient screening methods for the detection of novel species. The sequence data obtained in this study were compared to the available atpA and 16S rRNA gene sequences. The MLSA approach to Enterococcus taxonomy provides portable, highly reproducible data with lower costs for rapid identification of all enterococcal species.
BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae. (1994)

Brefeldin A (BFA) blocks protein transport out of the Golgi apparatus and causes disassembly of this organelle in mammalian cells. The primary effect of BFA is the release of the non-clathrin coat from Golgi membranes and vesicles. We sought to elucidate the mechanism of BFA action using a genetic approach in Saccharomyces cerevisiae. When an erg6 S. cerevisiae strain is treated with BFA, cell growth is arrested, cells lose viability and secretory proteins are accumulated in the endoplasmic reticulum (ER) and early Golgi compartments. We demonstrate that the mutant sec21 (defective in the S. cerevisiae homolog of gamma-COP, a non-clathrin coat protein) is supersensitive to BFA. Hence BFA probably affects the same processes in S. cerevisiae as in mammalian cells. We used a multicopy genomic DNA library to search for multicopy suppressors of BFA-induced lethality. We identified one such gene, BFR1, that, in addition, partially suppresses the growth and secretion defects of the ER-to-Golgi secretion mutant sec17. A bfr1-delta 1::URA3 deletion strain is viable, but has defects in cell morphology and nuclear segregation, and the mutation accentuates the growth and secretion defects of a sec21 mutant.
Colloidal Iron Staining in Renal Epithelial Neoplasms, Including Chromophobe Renal Cell Carcinoma (1998)

Positive staining with Hale's colloidal iron stain, or modifications thereof, is considered a diagnostic feature for chromophobe renal cell carcinoma and has been used as a discriminatory feature to differentiate it from other renal tumors. We studied colloidal iron staining in 62 cases encompassing a wide histologic spectrum of renal neoplasms (14 chromophobe renal cell carcinomas, 19 renal oncocytomas, 11 each of granular variants and conventional clear cell renal cell carcinomas, and 7 eosinophilic variants of papillary renal cell carcinoma) to investigate the specificity of the stain for chromophobe renal cell carcinoma. In cases of chromophobe renal cell carcinoma, sections from two different areas were stained to ascertain whether there was any spatial variation in staining. Influence of staining techniques on the results also was investigated by staining each case of chromophobe renal cell carcinoma using two different methods: the traditional Hale's and a modified Mowry's technique, which treats sections with 3% acetic acid before adding the colloidal iron. Our results show that positive staining with colloidal iron stain is not limited to chromophobe renal cell carcinoma, however, a diffuse and strong, reticular staining pattern was observed only in cases of chromophobe renal cell carcinoma (14 of 14). The staining patterns were less consistent in all other renal neoplasms and differed from the reaction observed in chromophobe renal cell carcinoma. Most renal oncocytomas (16 of 19) had focal and weak, fine dustlike positivity, and all clear cell carcinomas showed focal, coarse, dropletlike positive staining (22 of 22), in addition to a focal, coarse, bubbly pattern in 5 of 11 clear cell subtypes. Although all seven cases of the eosinophilic variant of papillary renal cell carcinoma showed strong, coarse, dropletlike staining, most of the positivity was coincident with the Perl's (prussian blue) reaction, indicating that the staining was due to hemosiderin, which is frequently present in this histologic subtype of renal cell carcinoma. Staining intensity did not vary considerably among different areas of chromophobe renal cell carcinoma, but the modified Mowry's method yielded brighter and sharper reticular staining, as compared with the Hale's method. Our results show that in the appropriate morphologic context diffuse and strong reticular positivity using the modified Mowry's colloidal iron stain method is highly characteristic for chromophobe renal cell carcinoma. Treatment of sections with 3% acetic acid before adding the colloidal iron gives technically superior staining results.
Longitudinal adaptive control of a platoon of vehicles (1999)

A technique for the longitudinal control of a platoon of automated vehicles is presented. A nonlinear model is used to represent the vehicle dynamics of each vehicle within the platoon. The controlled vehicle is assumed to be capable of measuring (or estimating) necessary dynamical information from the vehicle immediately in front of it by its on-board sensors. The computer in the vehicle processes the measured data and generates proper throttling and braking actions to follow the vehicle in front at a safe distance. Simulations are presented for the case of a platoon of four cars following a leader.
Deep Recurrent Models with Fast-Forward Connections for Neural Machine Translation (2016)

Neural machine translation (NMT) aims at solving machine translation (MT) problems using neural networks and has exhibited promising results in recent years. However, most of the existing NMT models are shallow and there is still a performance gap between a single NMT model and the best conventional MT system. In this work, we introduce a new type of linear connections, named fast-forward connections, based on deep Long Short-Term Memory (LSTM) networks, and an interleaved bi-directional architecture for stacking the LSTM layers. Fast-forward connections play an essential role in propagating the gradients and building a deep topology of depth 16. On the WMT’14 English-to-French task, we achieve BLEU=37.7 with a single attention model, which outperforms the corresponding single shallow model by 6.2 BLEU points. This is the first time that a single NMT model achieves state-of-the-art performance and outperforms the best conventional model by 0.7 BLEU points. We can still achieve BLEU=36.3 even without using an attention mechanism. After special handling of unknown words and model ensembling, we obtain the best score reported to date on this task with BLEU=40.4. Our models are also validated on the more difficult WMT’14 English-to-German task.
Disciplines (1995)

Photography can be divided up into a number of clearly defined disciplines, each of which require a slightly different approach. Inevitably there will be a certain amount of overlap but for practical purposes each should be treated as a separate subject. The City & Guilds 9231 series of exams enable the photographer to concentrate on a single subject such as portraiture, landscape, buildings, still life, etc. and produce a selection of well thought out and related images. Each of the modules must be undertaken on a theme, the topic itself is not sufficient. So for instance with still life the theme could be a colour or related objects, being made of the same material or having a similar use. Within buildings the theme could be a construction material, type of building or the work of a single architect. In portraiture the theme might be gender, race or even eyes. This thematic approach must be carried through the modules with a coherence that is equally strong and self-evident.
Comparative mechanisms of antiarrhythmic drug action in experimental atrial fibrillation. Importance of use-dependent effects on refractoriness. (1993)

We conclude that antiarrhythmic drugs terminate experimental atrial fibrillation by increasing the wavelength for reentry at rapid rates, leading to a reduction in the number of functional reentry circuits and, eventually, failure of reentrant excitation. Use-dependent effects on refractoriness can limit (in the case of the reverse use dependence of sotalol) or contribute (in the case of propafenone) to antiarrhythmic drug efficacy against atrial fibrillation by determining drug-induced changes in wavelength at rapid atrial rates.
[Interleukin-1 increase nitric oxide synthesis through up-regulation of inducible nitric-oxide synthase by rabbit mandibular condylar cartilage cells in vitro]. (2001)

IL-1 can inhibit the chondrocytes proliferation and induce apoptosis that might be through the way of up-regulation of iNOS expression.
Maximum Likelihood Estimation of Markov-Process Blob Boundaries in Noisy Images (1979)

Effective and elegant procedures have recently appeared in the published literature for determining by computer a highly variable blob boundary in a noisy image [1]-[3]. In this paper we point out that if the blob boundary is modeled as a Markov process and the additive noise is modeled as a white Gaussian noise field, then maximization of the joint likelihood of the hypothesized blob boundary and all of the image data results in roughly the same blob boundary determination as does one of the aforementioned deterministic formulations [2]. However, the formulation in this paper provides insights into and optimal parameter values for the functions involved and reveals suboptimalities in some of the formulations appearing in the literature. More generally, we agree that maximization of the joint likelihood of the hypothesized blob boundary and of the entire picture function is a fundamental approach to boundary estimation or the estimation of linear features (roads, rivers, etc.) in images, and provides a powerful mechanism for designing sequential, parallel, or other boundary estimation algorithms. The ripple filter, an advanced form of region growing, is briefly introduced and illustrates one of a number of alternative algorithms for maximizing the likelihood function. Hence, this likelihood maximization approach provides a unified view for seemingly different approaches, such as sequential boundary finding and region growing. Bounds on the accuracy of boundary estimation are readily derived with this formulation and are presented.
Business Rule Based Configuration Management and Software System Implementation Using Decision Tables (2007)

Abstract. Deployment and customization of the software in different information systems of separate organizations challenge large requirement conformity, project and specification management, design and architecture complexity, code integration, compatibility and interoperability issues, frequently causing the need of reengineering through the entire all the system development lifecycle. The paper proposes new business rule based method of information system configuration management and automated way of configuration implementation into the final software system code. 1
Positive Patch Test Reaction in a Patient Taking Dupilumab (2018)

Overview | The leading peer-reviewed scientific journal in contact dermatitis, and the only journal in its field that publishes leading research in atopic, contact, occupational, environmental, and drug dermatitis.
Biosynthesis of the Canine Zona Pellucida Requires the Integrated Participation of Both Oocytes and Granulosa Cells1 (2004)

In the dog, attempts to localize the expression of zona pellucida (ZP) proteins during folliculogenesis have failed to demonstrate conclusively whether any or all of the zona proteins are synthesized in the oocyte or the granulosa cells. Probing of paraformaldehyde-fixed prepubertal canine ovarian tissue sections with a panel of fluorescently conjugated lectins localized the expression of glycoproteins during folliculogenesis. We confirm that six lectins (PSA, s-WGA, ECL, GSL-II, LEL, and STL) consistently labeled the ZP and adjacent granulosa cells of the developing follicle and that canine ZP expresses beta-gal(1,4)glcNAc, beta-gal(1,3)galNac, alpha-mannose, and terminal sialic acid residues in a developmentally specific manner. Riboprobes for canine ZPA and ZPC genes were produced and used for in situ hybridization studies of mRNA expression in canine folliculogenesis. In addition, we isolated a partial cDNA transcript from total ovarian RNA for the canine ZPB gene having a high degree of sequence identity with the felid and porcine ZPB homologues. Subsequently, the ZPA gene transcripts were localized to the cytoplasm of oocytes in primordial, primary, and early secondary follicles. We then localized expression of ZPB and ZPC gene transcripts to the granulosa cells of growing follicles, but not in squamous granulosa cells of primordial follicles or oocytes. These observations indicate that in the juvenile canine ovary, the oocyte is responsible for synthesis of the ZPA protein and directing synthesis of the ZPB and ZPC proteins by the granulosa cells and that ZP gene transcription occurs in a sequential manner during folliculogenesis.