gebhart/patrepeval huggingface dataset:
The Extracellular Domain of Neurotrophin Receptor p75 as a Candidate Biomarker for Amyotrophic Lateral Sclerosis (2014)

Objective biomarkers for amyotrophic lateral sclerosis would facilitate the discovery of new treatments. The common neurotrophin receptor p75 is up regulated and the extracellular domain cleaved from injured neurons and peripheral glia in amyotrophic lateral sclerosis. We have tested the hypothesis that urinary levels of extracellular neurotrophin receptor p75 serve as a biomarker for both human motor amyotrophic lateral sclerosis and the SOD1(G93A) mouse model of the disease. The extracellular domain of neurotrophin receptor p75 was identified in the urine of amyotrophic lateral sclerosis patients by an immuno-precipitation/western blot procedure and confirmed by mass spectrometry. An ELISA was established to measure urinary extracellular neurotrophin receptor p75. The mean value for urinary extracellular neurotrophin receptor p75 from 28 amyotrophic lateral sclerosis patients measured by ELISA was 7.9±0.5 ng/mg creatinine and this was significantly higher (p<0.001) than 12 controls (2.6±0.2 ng/mg creatinine) and 19 patients with other neurological disease (Parkinson's disease and Multiple Sclerosis; 4.1±0.2 ng/mg creatinine). Pilot data of disease progression rates in 14 MND patients indicates that p75NTR(ECD) levels were significantly higher (p = 0.0041) in 7 rapidly progressing patients as compared to 7 with slowly progressing disease. Extracellular neurotrophin receptor p75 was also readily detected in SOD1(G93A) mice by immuno-precipitation/western blot before the onset of clinical symptoms. These findings indicate a significant relation between urinary extracellular neurotrophin receptor p75 levels and disease progression and suggests that it may be a useful marker of disease activity and progression in amyotrophic lateral sclerosis.
Photosynthetic Daily Light Integral Influences Flowering Time and Crop Characteristics of Cyclamen persicum (2009)

This study was carried out to examine the effect of photosynthetic daily light integral (DLI) on the growth and flowering of cyclamen ( Cyclamen persicum Mill. ‘Metis Scarlet Red’). Plants with six fully unfolded leaves were grown at 24/16 °C (12 h/12 h) under an 8- or 16-h photoperiod at a photosynthetic photon flux of 50, 100, 150, 200, and 300 μmol·m −2 ·s −1 , which provided seven DLIs: 1.4, 2.9, 4.3, 5.8, 8.6, 11.5, and 17.3 mol·m −2 ·d −1 . Days to first flower decreased from 133 to 75 as DLI increased from 1.4 to 17.3 mol·m −2 ·d −1 , although the acceleration of flowering was less pronounced when the DLI was greater than 5.8 mol·m −2 ·d −1 . Mean leaf and flower number increased from 8.7 to 28.0 and from 0 to 14.7, respectively, as DLI increased from 1.4 to 11.5 mol·m −2 ·d −1 , but there was no further increase under a DLI of 17.3 mol·m −2 ·d −1 . Total dry weight and net photosynthetic rate showed a similar trend as leaf and flower number. We conclude that supplemental lighting can accelerate greenhouse production of potted cyclamen under a low ambient DLI (i.e., less than 12 mol·m −2 ·d −1 ).
Comment on `Aharonov--Casher-Effect Suppression of Macroscopic Tunneling of Magnetic Flux' (2002)

A recent Letter [1] has proposed a device, consisting of an rf SQUID with the junction replaced by a double one, i.e. a Bloch transistor. For symmetric Josephson couplings, and for specific flux bias and gate voltage applied to the transistor's island, the tunneling of encircled flux between its two local potential minima is claimed to be suppressed completely due to destructive interference. This comment purports to show that this claim in general is not valid. Namely, the very Hamiltonian (1) in [1], from which the effect is derived, describes the circuit only under an additional condition. [1] J.R. Friedman and D.V. Averin, Phys. Rev. Lett._88_, 050403 (2002).
Advanced image sensor technology for pixel scaling down toward 1.0&#x00B5;m (Invited) (2008)

As pixel size of image sensors shrinks down rapidly, we are reaching technical barrier to get the required low light performance. In this paper, recent advanced technologies such as backside illumination, new color filter array, low F-number with extended depth of field technologies, etc. are introduced to overcome such a barrier. It is shown that the integration of these advanced sensor technologies can make pixel size shrink down toward 1.0 mum with the required performance.
The temporal dynamics of bacterial communities across human anterior nares (2011)

The anterior nares (nostrils), are an important niche for bacterial colonization by both commensals and opportunistic pathogens. Here the temporal dynamics and variation of the global nasal bacterial community across 25 healthy volunteers was evaluated over 15 months. Overall, there was a global seasonal shift in bacterial community structure. Such a temporal shift was also strongly evident in the abundances of species such as Propionibacterium acnes and Staphylococcus epidermidis. However, such species dynamics over time was also inter-individual-dependent, and both individuals with highly stable communities and those with highly flexible communities could be defined. Even though the bacterial community of individual volunteers was thus generally variable over time and permanent carriage of a given species was seldomly observed, various species previously defined as constituting the core bacterial community could be identified as persistent in a subset of the volunteers suggesting that these same species also constitute to a 'temporal' core community.
Pigmented Polymer Particles with Controlled Morphologies (1992)

In this study, mechanisms of phase separation as well as microencapsulation of pigments from polymer solutions are presented. Two types of pigmented polymer particles with different morphologies have been prepared by the microencapsulation process : 1) particles with pigment enriched on the surface and 2) particles with more fully encapsulated pigment. The morphologies as well as the surface properties of the encapsulated particles are controlled by the interactions between pigment, polymer and solvent which are dependent upon the functional groups on the pigment surface, the chemical structure of the polymer and the solvency. Photon correlation spectroscopy and scanning electron microscopy showed that the pigmented polymer particles have narrow size distribution and the size varied from 0.5µm to 2µm depending upon the pigment content and the solvency. Different techniques such as BET adsorption, densitometry, and microelectrophoresis are used to characterize the surface properties of the pigmented polymer particles. These results support a proposed mechanism for the microencapsulation and delineate morphologies of the encapsulated particles.
Polymer Makers Bridge The Gap (2000)

RETURN TO ISSUEPREVNewsNEXTPolymer Makers Bridge The GapTightening the value chain leads to innovation and cost savingsALEXANDER H. TULLOView Author Information C&EN Northeast News BureauCite this: Chem. Eng. News 2000, 78, 21, 21–26Publication Date (Print):May 22, 2000Publication History Published online12 November 2010Published inissue 22 May 2000https://pubs.acs.org/doi/10.1021/cen-v078n021.p021https://doi.org/10.1021/cen-v078n021.p021newsACS PublicationsCopyright © 2000 American Chemical SocietyArticle Views11Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Polymers Get e-Alerts
AG Institute Australia submission to senate inquiry on higher education and skills to support demand in agriculture and agribusiness in Australia (2011)

The Australian Institute of Agricultural Science and Technology, trading as Ag Institute Australia (AIA) is pleased to have the opportunity to make a submission to this Inquiry.
Magnetostatic Modes of a Ferromagnetic Slab (1960)

The characteristic modes of a thin slab magnetized in its plane are obtained in the magnetostatic limit,and the mode spectrum and configuration are discussed. The wavelength dependence of magnetostatic mode density is determined and utilized to establish a connection to the modes obtained in the spin-wave approximation. In this geometry the modes lying above the spin-wave band are surface waves, decaying toward the interior of the slab, while volume modes occur in the same frequency range as the long-wavelength limit of the spin-wave band of an infinite medium. The mode density exhibits poles at the upper and lower frequency limits of the surface mode spectrum. The surface modes become statistically less important at shorter wavelengths because the ratio of surface mode density to volume mode density varies approximately as 1/|k|.
Scientific and Technical Aspects of Yogurt Aroma and Taste: A Review (2011)

Abstract: Yogurt is a basic dairy product that has been consumed for centuries as a part of the diet, even when its beneficial effects were neither fully known nor scientifically proven. With time, yogurt has been continuously modified to obtain a product with better appeal and nutritional effects. The flavor components of yogurt are affected because of these modifications. The present review article is focused on the influence of the different parameters and modifications on aroma and taste components of yogurt. Extensive work has been done to explore the effect of chemical components as well as the microbial, processing, and storage aspects. The popularity of yogurt as a food component depends mainly on its sensory characteristics, of which aroma and taste are most important. This review also outlines the effects of the different modifications attempted in the composition of yogurt.
Dose-dependent effects of capsaicin nasal challenge: In vivo evidence of human airway neurogenic inflammation (1997)

Capsaicin-sensitive nerve stimulation in subjects with active allergic rhinitis produces reproducible and dose-dependent leukocyte influx, albumin leakage, and glandular secretion. These results provide in vivo evidence for the occurrence of neurogenic inflammation in the human upper airway with active allergic disease.
Action of epoxyeicosatrienoic acids on cellular function (2006)

Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by cytochrome P-450 epoxygenases. They activate smooth muscle large-conductance Ca(2+)-activated K(+) channels, producing hyperpolarization and vasorelaxation. EETs also have anti-inflammatory effects in the vasculature and kidney, stimulate angiogenesis, and have mitogenic effects in the kidney. Many of the functional effects of EETs occur through activation of signal transduction pathways and modulation of gene expression, events probably initiated by binding to a putative cell surface EET receptor. However, EETs are rapidly taken up by cells and are incorporated into and released from phospholipids, suggesting that some functional effects may occur through a direct interaction between the EET and an intracellular effector system. In this regard, EETs and several of their metabolites activate peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma, suggesting that some functional effects may result from PPAR activation. EETs are metabolized primarily by conversion to dihydroxyeicosatrienoic acids (DHETs), a reaction catalyzed by soluble epoxide hydrolase (sEH). Many potentially beneficial actions of EETs are attenuated upon conversion to DHETs, which do not appear to be essential under routine conditions. Therefore, sEH is considered a potential therapeutic target for enhancing the beneficial functions of EETs.
Cumulative Index, Volume 3 Nos. 13–24 (1992)

plan payments for taxes 99, 131
Scalable and Parallel Aggregated Bit Vector Packet Classification Using Prefix Computation Model (2006)

The Internet traffic gets exploded due to the increasing demand for bandwidth as more number of users gets added to the Internet. In order to meet the demands of the growing needs, the working of various devices and operations has to be redesigned. One of the areas is the design of the high performance router. The traditional router performs two basic tasks in forwarding a packet. Firstly, looking up the packet's destination address in the router's database and secondly, switching the packet to one or more of the outgoing links. The classification of packets at the router based upon multiple fields is called as packet classification. In this paper, we propose an aggregate bit vector packet classification using prefix computation model (ABVPC using PCM) which combines the effect of both scalability and parallelization. It is aimed at overcoming the defects of the existing ABV algorithms. Simulation results illustrate that the folding technique using PCM significantly improves the performance
A novel approach to the preparation of thermoplastic polyurethane elastomer and polyamide 6 blends by <i>in situ</i> anionic ring‐opening polymerization of ε‐caprolactam (2006)

Abstract Blends of thermoplastic polyether‐based urethane elastomer (TPEU) and monomer casting polyamide 6 (MCPA6) were prepared using ε‐caprolactam as reactive solvent, with caprolactam sodium as a catalyst in the presence of TPEU, with TPEU content varying from 2.5% to 10% by weight. In situ anionic ring‐opening polymerization and in situ compatibilization to prepare TPEU/MCPA6 blends were carried out in one step. The TPEU chains, which underwent thermal dissociation in amine solvents to bear isocyanate groups, acted as macroactivator to initiate MCPA6 chain growth from the TPEU chains and form graft copolymers of TPEU‐ co ‐MCPA6 to improve compatibility between TPEU and MCPA6. The structure and thermal properties were characterized by means of Fourier transform infrared spectroscopy, 1 H‐NMR spectroscopy, differential scanning calorimetry and scanning electron microscopy. Copyright © 2006 Society of Chemical Industry
Automatic car steering control bridges over the driver reaction time (1997)

: A car driver needs at least five hundred milliseconds before he can react to unexpected yaw motions. During this time the uncontrolled car may produce a dangerous yaw rate and sideslip angle. Automatic steering control for disturbance rejection is designed such that it bridges over the driver reaction time, but returns the full steering authority to the driver thereafter. The solution is robust with respect to uncertainties in the road-tire contact and in the mass and velocity of the vehicle. The model representation is scaled by methods of similarity mechanics. 1 Introduction Critical car driving situations arise, when a disturbance torque acts on the vehicle. Examples are crosswind, flat tire, braking on a slippery road and gas release in a curve. It takes the driver at least five hundred milliseconds to react to the resulting yaw motion of his car. During this time the tire sideforce may already reach its physical limits. A delayed overreaction of the driver may also cause drive...
The physics of the environmental sensitivity of rubidium gas cell atomic frequency standards (1992)

The physical mechanisms behind environmental sensitivity are considered, and they are related to the performances of rubidium frequency standards (RFSs). Some of the RFS environmental sensitivities are due to simple physical mechanisms like the effect of DC magnetic field on the Rb hyperfine resonance frequency. For these, an analysis can be based on physical principles and straightforward design factors. Other environmental factors, like temperature sensitivity, are more complex combinations of many effects, both physical and practical, and the analysis often takes the form of an error budget, with large unit-to-unit variations. Today's RFSs span a wide performance range from small, inexpensive units with pp10(10) error budgets to larger, higher-performance versions offering pp10(14) stabilities. For both extremes, however, environmental sensitivity can be the most significant performance limitation. Why this is the case is explained, and some insight into how to make improvements is offered.
Prostaglandin E2 enhances and gamma interferon inhibits germ tube formation in Candida albicans (1990)

Prostaglandin E2 (PGE2), an immunosuppressive monokine that increases intracellular cyclic AMP (cAMP) levels, stimulated Candida albicans germ tube formation. Dibutyryl cAMP (dB-cAMP) and isoproterenol, other compounds that increase cAMP levels, also stimulated germination. Gamma interferon (IFN-gamma), a product of cellular immune system activation, inhibited Candida germ tube formation, even in the presence of PGE2, dB-cAMP, and isoproterenol. Thus, PGE2 and IFN-gamma as well as having opposing roles in the suppression or activation of cell-mediated immunity, are also antagonists for the yeast-to-hyphal transition of C. albicans.
Sensing Picomolar Concentrations of RNA Using Switchable Plasmonic Chirality (2018)

Abstract Detecting small sequences of RNA in biological samples such as microRNA or viral RNA demands highly sensitive and specific methods. Here, a reconfigurable DNA origami template has been used where a chiral arrangement of gold nanorods on the structure can lead to the generation of strong circular dichroism (CD). Switching of the cross‐like DNA structure is achieved by the addition of nucleic acid sequences, which arrests the structure in one of the possible chiral states by specific molecular recognition. A specific sequence can thus be detected through the resulting changes in the plasmonic CD spectrum. We show the sensitive and selective detection of a target RNA sequence from the hepatitis C virus genome. The RNA binds to a complementary sequence that is part of the lock mechanism, which leads to the formation of a defined state of the plasmonic system with a distinct optical response. With this approach, we were able to detect this specific RNA sequence at concentrations as low as 100 p m .
Silver ion-assisted solvolysis of phenacyl halides in aqueous ethanol (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilver ion-assisted solvolysis of phenacyl halides in aqueous ethanolDaniel J. Pasto and Klaus GarvesCite this: J. Org. Chem. 1967, 32, 3, 778–781Publication Date (Print):March 1, 1967Publication History Published online1 May 2002Published inissue 1 March 1967https://pubs.acs.org/doi/10.1021/jo01278a058https://doi.org/10.1021/jo01278a058research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bond moments, molecular moments, electronegativity, and the dipole moment of methylsilane (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBond moments, molecular moments, electronegativity, and the dipole moment of methylsilaneJon M. Bellama, Robert S. Evans, and James E. HuheeyCite this: J. Am. Chem. Soc. 1973, 95, 22, 7242–7244Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ja00803a010https://doi.org/10.1021/ja00803a010research-articleACS PublicationsRequest reuse permissionsArticle Views237Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robustness of collaborative recommendation based on association rule mining (2007)

Standard memory-based collaborative filtering algorithms, such as k-nearest neighbor, are quite vulnerable to profile injection attacks. Previous work has shown that some model-based techniques are more robust than k-nn. Model abstraction can inhibit certain aspects of an attack, providing an algorithmic approach to minimizing attack effectiveness. In this paper, we examine the robustness of a recommendation algorithm based on the data mining technique of association rule mining. Our results show that the Apriori algorithm offers large improvement in stability and robustness compared to k-nearest neighbor and other model-based techniques we have studied. Furthermore, our results show that Apriori can achieve comparable recommendation accuracy to k-nn.
Le changement organisationnel à La Poste (1996)

Entreprise publique, contrôle de gestion, changement
Optimizing genome editing strategy by primer-extension-mediated sequencing (2019)

Efficient and precise genome editing is essential for clinical applications and generating animal models, which requires engineered nucleases with high editing ability while low off-target activity. Here we present a high-throughput sequencing method, primer-extension-mediated sequencing (PEM-seq), to comprehensively assess both editing ability and specificity of engineered nucleases. We showed CRISPR/Cas9-generated breaks could lead to chromosomal translocations and large deletions by PEM-seq. We also found that Cas9 nickase possessed lower off-target activity while with some loss of target cleavage ability. However, high-fidelity Cas9 variants, including both eCas9 and the new FeCas9, could significantly reduce the Cas9 off-target activity with no obvious editing retardation. Moreover, we found AcrIIA4 inhibitor could greatly reduce the activities of Cas9, but off-target loci were not so effectively suppressed as the on-target sites. Therefore, PEM-seq fully evaluating engineered nucleases could help choose better genome editing strategy at given loci than other methods detecting only off-target activity.