gebhart/patrepeval huggingface dataset:
Molecular characterization of clear cell renal cell carcinoma identifies <scp>CSNK</scp>2A1, <scp>SPP</scp>1 and <scp>DEFB</scp>1 as promising novel prognostic markers (2016)

The prognosis associated with clear cell renal carcinoma (ccRCC) can vary widely and novel molecular prognostic markers are needed to assess prognosis at an earlier stage. Several gene products have been investigated for this purpose, but none of them have been implemented in clinical practice. Here we hypothesized that we, using TaqMan® Array, could identify superior prognostic messenger RNA (mRNA)s in long-term follow-up. Messenger RNA level of 19 candidate genes was investigated in 97 patients with ccRCC. Three genes impacted significantly on prognosis in both univariate and multivariate analysis. In univariate analysis, CSNK2A1 was a strong indicator of a poor overall survival (OS) (HR = 5.01, p < 0.001), disease specific survival (DSS) (HR = 6.21, p = 0.007) and progression free survival (PFS) (HR = 5.93, p = 0.005). High expression of SPP1 was associated to poor PFS (HR = 4.41, p = 0.04). DEFB1 was associated with a better PFS (HR = 0.24, p = 0.006). In multivariate analysis, CSNK2A1 was associated to a worse OS (HR = 3.56, p = 0.008) and PFS (HR = 3.84, p = 0.005), whereas SPP1 was an independent predictor of a worse PFS (HR = 3.46, p = 0.007) and DEFB1 of a better PFS (HR = 0.37, p = 0.027). These results show that with TaqMan®) Array we could identify three superior gene products related to prognosis. Further studies are needed to elucidate the pathways and roles of these genes in renal cacer development.
Redundancy in Linked Data Partitioning for Efficient Query Evaluation (2015)

The problem of efficient querying large amount of linked data using Map-Reduce is investigated in this paper. The proposed approach is based on the following assumptions: a) Data graphs are arbitrarily partitioned in the distributed file system is such a way that replication of data triples between the data segments is allowed. b) Data triples are replicated is such a way that answers to a special form of queries, called subject-object star queries, can be obtained from a single data segment. c) Each query posed by the user, can be transformed into a set of subject-object star sub queries. We propose a one and a half phase, scalable, Map-Reduce algorithm that efficiently computes the answers of the initial query by computing and appropriately combining the sub query answers. We prove that, under certain conditions, query can be answered in a single map-reduce phase.
Analysis of the alloreactive capacity of human umbilical cord blood: implications for graft-versus-host disease. (1994)

Hematopoietic reconstitution by bone marrow transplantation (BMT) is used as therapy for the treatment of various malignancies and genetic blood disorders. Allogeneic BMT is the most common application of this treatment but is frequently associated with graft-versus-host disease (GVHD). Recent clinical studies have shown that sibling transplant using umbilical cord blood (UCB) is an acceptable alternative to BMT and may involve fewer problems with GVHD. We have investigated the in vitro alloreactive capacity of UCB as it relates to allogeneic transplantation. Initial screening assays demonstrated that UCB T cells were functionally immature. It was not possible to generate significant levels of alloantigen-specific cytotoxic T lymphocytes (CTL) in either primary or secondary mixed lymphocyte cultures. Limiting dilution analyses revealed that cord blood T cells were 10-1000 x less alloreactive in terms of proliferative T cells (PTLp) and cytotoxic T cells (CTLp) compared with adult peripheral blood lymphocytes (PBL). However, UCB was equivalent to adult PBL in terms of natural killer (NK) and lymphokine-activated killer (LAK) cell precursors. Analysis of cells from alloantigen-stimulated MLC revealed that UCB generated primarily CD4+ and CD16+ cells that made little or no IL-4, IL-6, TNF-alpha or IFN-gamma on antigenic stimulation. Cold target inhibition analyses revealed that alloantigen-stimulated cord blood T cells had a fine specificity similar to NK cells. From these in vitro results cord blood would seem to be unlikely to mediate severe GVHD reactions in vivo and should be suitable for allogeneic transplantation.
Preischemic glycogen reduction or glycolytic inhibition improves postischemic recovery of hypertrophied rat hearts (1994)

The purpose of this study was to determine whether metabolites produced by glycolysis during ischemia significantly contribute to myocardial injury of hypertrophied hearts. The accumulation of glycolytic metabolites during ischemia was reduced by means of glycogen reduction or by treatment with the glycolytic inhibitor, 2-deoxy-D-glucose (2-DG) before ischemia. Hearts from aortic-banded (Band) and sham-operated (Sham) rats (8 wk postop) were isolated, perfused with Krebs buffer, and had a left ventricular (LV) balloon to measure developed pressure. A 15-min perfusion with hypoxic buffer (glycogen reduction, GR) or a 10-min perfusion with 10 mM 2-DG (glycolytic inhibition) was followed by 25 min global, normothermic, no-flow ischemia and 30 min normoxic reperfusion. Heart weights were greater in Band than Sham [2.76 +/- 0.06 vs. 1.5 +/- 0.04 (mean +/- SE) g; P < 0.001]. GR and 2-DG each resulted in reduced ATP levels measured at the beginning of ischemia in both Band and Sham groups compared with untreated groups, but there were no differences among groups after 25 min of ischemia. Myocardial lactate levels at the end of ischemia were significantly reduced in both Band and Sham hearts with GR or 2-DG compared with untreated controls. Recovery of LV function after ischemia and reperfusion was significantly improved in Band after GR (206% increase) and after 2-DG treatment (126% increase) compared with their respective untreated controls. Diastolic dysfunction during reperfusion was ameliorated in Band by preischemic GR but not by 2-DG treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
2차 Reed-Muller부호를 위한 부호영역에서의 복호알고리즘 (2002)

In this paper,the majority-logic based coding-domain decoding algorithms of the second order Reed-Muller codes RM_q(2,m) for orthogonal frequency...
Product stewardship in the flame retardant industry (2004)

Abstract The products of the flame retardant industry are very important to the fire safety of the consumer. As with any product, there are issues that must be addressed by the producers and users to ensure the continued safe use of the materials. While most flame retardants are quite nonreactive and of low toxicity, the presence of them in the environment could threaten their future use. The producers and users alike should have the goal of keeping them out of the air, water and land. To this end, an aggressive product stewardship program is in order. This paper will review the steps needed to have a meaningful program. This activity should include evaluating the amount of material entering the air, water and land, deciding how to reduce that amount, putting in place practices to reduce the level and reporting to our stakeholders. By working together as producers and users, we can ensure that flame retardants will continue to save lives and have a long commercial future. Copyright © 2004 John Wiley & Sons, Ltd.
Conditions for Series Arcing Phenomena in PVC Wiring (2007)

Under certain circumstances, unintentional series arcing, caused from damaged line cords and loose connections, can pose a serious fire and safety hazard. This work, focusing on residential 115 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ac</sub> applications, shows how continuous bursts of ignited gases can be created from overheated polyvinyl chloride (PVC) insulation created from glowing contacts with subsequent series arcing, or surface breakdown with subsequent series arcing. Also, surprisingly, these potentially hazardous fire conditions were created with currents as low as 0.9 A <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> at 115 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ac</sub> (100 W lamp load). Little research is available about the interaction of glowing contacts, formed from loose or broken copper conductors in wiring (outlets, switches, line conductors, etc.), with electrical insulation. This work shows how glowing contacts and surface arcing can decompose PVC insulation, form ignitable gases, and that it is possible for the subsequent series arc to ignite, and burn insulation. Two conditions are identified that can create an overheated connection-a glowing contact and/or breakdown over a charred insulation surface. Mechanisms are discussed along with data for glowing contact voltage drop, photographs of glowing connections, and a gas chromatograph analysis of the evolved gases emitted from overheated PVC wiring. Selected high-speed video frames (1000 fps) taken from videos of the series arc and bursts of ignitable gasses along with synchronized current and voltage waveforms over a current range of 0.9 A <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> to 5 A <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> are presented. These findings are useful for advancing the state-of-the-art in fire protection by providing a better understanding of how electrical fires can initiate.
High efficiency electrostatic filter built with dual wire fibres (2002)

The authors present the construction, operation, and resulting filtration efficiencies of a new type of electrostatic filter of very low pressure drop at usual flow-through velocities while providing excellent filtration for micron-size particles. The filter is constructed in the form of a thick mesh of dual wire fibers, electrically energized at approximately 200 DC volts, and reversing the polarity at a frequency on the order of 5 mHz. While, in general, high-efficiency mechanical filters trap the particles on the air incoming surface, with subsequent rapid blinding, the new filter collects the particles inside the mesh volume, thus offering a considerably longer life. It is concluded that the AC power polarized dual wire fiber is a promising replacement for the electret fiber on account of its infinite life and very high obtainable electric fields.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Temporal Evolution of Electromagnetic Markers Sensitive to the Capacity Limits of Visual Short-Term Memory (2011)

An electroencephalographic (EEG) marker of the limited contents of human visual short-term memory (VSTM) has previously been described. Termed contralateral delay activity, this consists of a sustained, posterior, negative potential that correlates with memory load and is greatest contralateral to the remembered hemifield. The current investigation replicates this finding and uses magnetoencephalography (MEG) to characterize its magnetic counterparts and their neural generators as they evolve throughout the memory delay. A parametric manipulation of memory load, within and beyond capacity limits, allows separation of signals that asymptote with behavioral VSTM performance from additional responses that contribute to a linear increase with set-size. Both EEG and MEG yielded bilateral signals that track the number of objects held in memory, and contralateral signals that are independent of memory load. In MEG, unlike EEG, the contralateral interaction between hemisphere and item load is much weaker, suggesting that bilateral and contralateral markers of memory load reflect distinct sources to which EEG and MEG are differentially sensitive. Nonetheless, source estimation allowed both the bilateral and the weaker contralateral capacity-limited responses to be localized, along with a load-independent contralateral signal. Sources of global and hemisphere-specific signals all localized to the posterior intraparietal sulcus during the early delay. However the bilateral load response peaked earlier and its generators shifted later in the delay. Therefore the hemifield-specific response may be more closely tied to memory maintenance while the global load response may be involved in initial processing of a limited number of attended objects, such as their individuation or consolidation into memory.
A Technique for Pulling Single Crystals of Volatile Materials (1962)

A technique has been developed to pull single crystals of volatile materials using standard pulling apparatus. This has been accomplished by covering the surface of the material to be pulled with a substance that is liquid at the pulling temperature. Crystals of PbTe and PbSe were pulled using molten B2O3 as the surface liquid.
Continuous ST-Segment Monitoring: Nurses’ Attitudes, Practices, and Quality of Patient Care (2011)

ST Map was associated with more frequent use of ischemia monitoring, improved attitudes of nurses toward ischemia monitoring, and shorter time to obtaining 12-lead electrocardiograms.
[Natural history of systemic lupus erythematosus: the experience at the Arnaldo Vieira de Carvalho Cancer Institute]. (1990)

The authors present an evaluation of sixty patients with SLE who were observed at the "Arnaldo Vieira de Carvalho" Cancer Institute from 1980 to 1988. Their findings were compared to findings of other international series. Some differences were observed in the frequency of clinical manifestations, laboratory findings, and mortality.
Of Inference, or Reasoning, in general (2011)

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The Effect of FIR Filtering and Spectral Tilt on Speech Recognition with MFCC (2010)

In an effort to enhance the quality of feature vector classification and thereby reduce the recognition error rate for the speaker-independent speech recognition, we study the effect of spectral tilt on the Fourier magnitude spectrum en route to the extraction of MFCC. The effect of FIR filtering on the speech signal on the speech recognition is also investigated in parallel. Evaluation of the proposed methods are performed by two independent ways of the Fisher discriminant objective function and speech recognition test by hidden Markov model with fuzzy vector quantization. From the experiments, the recognition error rate is found to show about 10% relative improvements over the conventional method by an appropriate choice of the tilt factor.
Glucan as an adjuvant for a murine Babesia microti immunization trial (1982)

A vaccination protocol against murine Babesia microti infection, using glucan, a beta-1,3-glucopyranose derivative of yeast cell walls, and glutaraldehyde-fixed infected erythrocytes was evaluated. BALB/c mice were immunized intravenously four times at 2-day intervals with 2 X 10(8) fixed infected erythrocytes with and without glucan (0.45 mg). The mice were challenged 2 weeks after the last immunization with 10(8) viable infected erythrocytes. Peak parasitemia was significantly reduced (8.9 +/- 1.0%; P less than 0.001) in glucan-immunized mice as compared with nonimmunized controls (41.2 +/- 1.4%), glucan-treated controls (31.7 +/- 2.5%; P less than 0.05), or mice which received fixed infected erythrocytes without glucan (21.0 +/- 1.2%; P less than 0.01). Humoral and cellular immunity to B. microti was evaluated before challenge by measuring antibody titers and splenocyte blastogenic responses to B. microti antigens. The in vitro cellular response was inversely correlated with mean peak parasitemia (P less than 0.05). These observations demonstrate that glucan is an effective adjuvant in enhancing immunity to murine babesiosis.
Modulation strategy for minimizing commutations and capacitor voltage balancing in symmetrical cascaded multilevel converters (2011)

Multilevel inverters are suitable for power quality applications because the converter can be directly applied in medium voltage distribution systems. If the converter is not required to deliver active power to a load, a power source is not necessary, and the converter can operate only with capacitors on the DC side. This paper presents a strategy for the symmetrical cascade inverter that balances individual DC voltages and minimizes switching losses by eliminating useless commutations. If the converter has redundant modules to increase reliability, the duty-cycle and the losses of each module can be evenly distributed.
Clinical spectrum and management of dengue haemorrhagic fever. (1987)

Le mecanisme pathogenique de la dengue hemorragique est complique et beaucoup reste a explorer. Le tableau clinique est si typique qu'avec les criteres de l'OMS un diagnostic precoce peut etre fait avec une exactitude de 95%. Le diagnostic et l'intervention precoces peuvent modifier la gravite de la maladie. Les connaissances actuelles sont suffisantes pour reduire la mortalite a un minimum
Studies on 1,3-dipolar cycloaddition reactions of some cycloimmonium ylides (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on 1,3-dipolar cycloaddition reactions of some cycloimmonium ylidesRam S. Tewari, Priya D. Dixit, and Ajay K. DubeyCite this: J. Chem. Eng. Data 1983, 28, 2, 283–285Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/je00032a044https://doi.org/10.1021/je00032a044research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biogenese von freiem und sulfatiertem 7α-Hydroxy-androstenolon in Zellfraktionen der Rattenleber (1967)

Article Biogenese von freiem und sulfatiertem 7α-Hydroxy-androstenolon in Zellfraktionen der Rattenleber was published on January 1, 1967 in the journal Biological Chemistry (volume 348, issue Jahresband).
Hiccups: Causes and Cures (1985)

Hiccups result from a wide variety of conditions that act on the supraspinal hiccup center or that stimulate or disinhibit the limbs of its reflex arc. While scores of hiccup remedies have been reported over the centuries, no single "cure" stands out as being the most effective. Measures that stimulate the uvula or pharynx or disrupt diaphragmatic (respiratory) rhythm are simple to use and often help to speed the end of a bout of otherwise benign, self-limited hiccups. Such manueuvers may also terminate persistent hiccups. Drug therapy usually becomes necessary for more intractable hiccups; chlorpromazine and metoclopramide being two of the most widely employed agents for this purpose. Physical disruption of the phrenic nerve, hypnosis, and acupuncture are other modes of therapy that have been used in severe cases. Because so many reports of hiccup "cures" are based on anecdotal experience rather than controlled clinical studies, I review the available treatments to provide a rational approach for the management of hiccups.
Elastic <i>a</i>-Silicon Nanoparticle Backboned Graphene Hybrid as a Self-Compacting Anode for High-Rate Lithium Ion Batteries (2014)

Although various Si-based graphene nanocomposites provide enhanced electrochemical performance, these candidates still yield low initial coloumbic efficiency, electrical disconnection, and fracture due to huge volume changes after extended cycles lead to severe capacity fading and increase in internal impedance. Therefore, an innovative structure to solve these problems is needed. In this study, an amorphous (a) silicon nanoparticle backboned graphene nanocomposite (a-SBG) for high-power lithium ion battery anodes was prepared. The a-SBG provides ideal electrode structures-a uniform distribution of amorphous silicon nanoparticle islands (particle size <10 nm) on both sides of graphene sheets-which address the improved kinetics and cycling stability issues of the silicon anodes. a-Si in the composite shows elastic behavior during lithium alloying and dealloying: the pristine particle size is restored after cycling, and the electrode thickness decreases during the cycles as a result of self-compacting. This noble architecture facilitates superior electrochemical performance in Li ion cells, with a specific energy of 468 W h kg(-1) and 288 W h kg(-1) under a specific power of 7 kW kg(-1) and 11 kW kg(-1), respectively.
The Shallows: What the Internet Is Doing to Our Brains (2010)

Carr, Nicholas. Shallows: What the Internet Doing to Our Brains. New York: W.W. Norton, 2010. 276 pp. $26.95. Making sense of new technology is always a precarious business. In 1939, a New York Times review of television at the World's Fair said: The problem with television is that people must sit and keep their eyes glued on a screen; the average American family hasn't time for it. To be fair, however, people's powers of discernment are rarely capable of envisioning a world that does not yet exist, a world created in part by a new medium they do not fully understand. Nicholas Carr may not be right in his assessment of the Internet, but he does at least try to inject some scientific rigor into the analysis, and he is no anchorite, fearful of gadgets or atremble before DSL, all of which makes him a formidable media critic. In 2008, he wrote a cover article for Athntic in which he asked a provocative question: Is Google Making Us Stupid? In many respects, he concluded, yes. We read less and we remember less. In blog exchanges with Carr, New York University professor Clay Shirky has defended online reading and poked fun at bibliophiles: The threat isn't that people will stop reading War and Peace. That day is long since past. threat is that people will stop genuflecting to the idea of reading War and Peace!' Carr, in return, criticizes Shirky in personal terms: Such proclamations seems a little too staged to take seriously. They come off as the latest manifestation of the outre posturing that has always characterized the anti-intellectual wing of academia. It has otherwise been a fairly civilized debate. And their positions are rarely mutually exclusive, so while the feud has been instructive to witness, it also has been frustrating. Carr whiffs in his opening gambit in Shalhws. He starts with unconvincing anecdotes about his own dumbing-down and that of his friends: how they're supposedly finding it more difficult to concentrate, to read, or to write with sustained focus, to engage in deep contemplation. It is impossible to read this without wondering whether the culprit is not so much the deterioration of his brain as it is the demands of his job or the nature of his personality. Also, I am finding just the opposite: I can read more now than ever before. Does my anecdote trump his anecdote? Fortunately, he does not rely on anecdotes but on several studies in neurology and psychology, all attesting to the brain's malleability, to its neuroplasticity. And what this research shows is troubling. …