gebhart/patrepeval huggingface dataset:
Comparison of the Hydrolysis Patterns of Several tRNAs by Cobra Venom Ribonuclease in Different Steps of the Aminoacylation Reaction (1982)

The hydrolysis of several tRNAs by an endonuclease extracted from the venom of Naja oxiana and specific for double-stranded, or at least highly ordered, regions has been studied under various experimental conditions. It is shown that the hydrolysis patterns of yeast tRNAPhe, tRNAVal and tRNAAsp in the isolated state are similar, most of the cuts occurring in the anticodon and acceptor stems. Ionic conditions are able to modify the hydrolysis pattern. The origin of these modifications is discussed. The protection against ribonuclease action, afforded to tRNAPhe, tRNAVal and tRNAAsp by the cognate aminoacyl-tRNA synthetase, is analyzed. It is shown that in all cases the anticodon stem is protected. The 3'-terminal region does not seem to be tightly engaged in the complex with the aminoacyl-tRNA synthetase. These results are discussed in the light of information on contact areas previously obtained by ultraviolet cross-linking techniques. The effects of the small ligands (ATP and amino acid) on the protection afforded to the tRNA by the cognate synthetase, have been studied. In the valine and aspartic acid systems, ATP induced a modification of the tRNA-enzyme complex leading to differences in the hydrolysis pattern of the 3'-accepting region. The effects of aminoacylation on the cleavage of tRNAPhe, tRNAVal and tRNAAsp were also studied. Whereas no modification of the cleavage map was observed in the aspartic system, aminoacylation resulted in slight but significant modifications of the hydrolysis pattern for tRNAPhe and tRNaVal in the 3'-terminal region.
Adaptive Downsampling for High-Definition Video Coding (2014)

Previous research has shown that downsampling prior to encoding and upsampling after decoding can improve the rate-distortion (R-D) performance compared with directly coding the original video using standard technologies, e.g., JPEG and H.264/AVC, especially at low bit rates. This paper proposes a practical algorithm to find the optimal downsampling ratio that balances the distortions caused by downsampling and coding, thus achieving the overall optimal R-D performance. Given the optimal sampling ratio, dedicated filters for down- and upsampling are also designed. Simulations show this algorithm improves the R-D performance over a wide range of bit rates.
<title>Relational-database model for improving quality assurance and process control in a composite manufacturing environment</title> (2000)

A relational database is a powerful tool for collecting and analyzing the vast amounts of inner-related data associated with the manufacture of composite materials. A relational database contains many individual database tables that store data that are related in some fashion. Manufacturing process variables as well as quality assurance measurements can be collected and stored in database tables indexed according to lot numbers, part type or individual serial numbers. Relationships between manufacturing process and product quality can then be correlated over a wide range of product types and process variations. This paper presents details on how relational databases are used to collect, store, and analyze process variables and quality assurance data associated with the manufacture of advanced composite materials. Important considerations are covered including how the various types of data are organized and how relationships between the data are defined. Employing relational database techniques to establish correlative relationships between process variables and quality assurance measurements is then explored. Finally, the benefits of database techniques such as data warehousing, data mining and web based client/server architectures are discussed in the context of composite material manufacturing.
Design Guide for Fluidic Laminar Proportional Amplifiers and Laminar Jet Angular Rate Sensors (1984)

Abstract : This report provides technical information on the design, performance, and fabrication of fluidic laminar proportional amplifiers and laminar jet angular rate sensors (LJAR's). Standard amplifier designs and formats are presented which allow the use to select amplifier characteristics most suitable for each specific application. Various methods for fabricating elements are described, and information relating to the effects of fabrication inaccuracies are presented in this report. The LJARS is described, and the advantages of applying laminar fluidics to the vast field of sensors is shown. Several circuit arrangements and the performance achieved with these circuits are presented. Charts and other reference material are also included.
MÖSSBAUER STUDY OF RARE EARTH BONE UPTAKE (1979)

The existence of an emission Mössbauer effect after uptake to a trivalent ion of rare earth on bone mineral particles , either by "in vitro" adsorption or after "in vivo" metabolic uptake, has been revealed. Study of the hyperfine spectra obtained at 4.2K seems to indicate that the adsorbed ion is found within two monolayers of hydration water molecules in an environment of hydroxyl groups similar to the structure of a rare earth hydroxide.
The relationship between symptomatology and treatment selection in metastatic castrate-resistant prostate cancer. (2011)

Metastatic castrate-resistant prostate cancer (CRPC) can occur in a patient with de novo metastatic disease who has received androgen-deprivation therapy. The initial evaluation of a patient who may have CRPC should include measurement of testosterone levels at the time of progression to confirm the presence of castrate levels of testosterone. Components of the workup include a baseline bone scan, a computed tomography scan, and a full blood panel. The follow-up of patients with metastatic CRPC should include measurement of prostate-specific antigen (PSA) levels as well as imaging studies. The most important clinical endpoint for these patients is survival, but others include symptoms, such as pain and fatigue; biochemical factors; and radiographic progression. Physicians must help manage symptoms, regardless of whether they arise from the treatment or the disease itself. For patients with metastatic CRPC, choice of treatment is driven primarily by whether the patient has asymptomatic or minimally symptomatic, versus symptomatic, disease. In this clinical roundtable monograph, experts discuss the diagnosis, prognosis, and management of patients with CRPC, with a focus on the best utilization of 4 recently approved agents: abiraterone acetate, sipuleucel-T, cabazitaxel, and denosumab.
A spurious emission reduction technique for power amplifiers using frequency hopping DC-DC converters (2009)

This paper presents a spurious emission suppression technique for RF power amplifiers using frequency-hopping DC-DC converters. The frequency-hopping technique changes the switching frequency of the DC-DC converter dynamically and reduces the peak spur created by using a DC-DC converter with a radio frequency power amplifier. The use of this technique can also reduce the size of the external passive components used for reducing the ripple voltage of the DC-DC converter, which creates the radio frequency spurs. A prototype system using a cellular band power amplifier operating at 836.5 MHz and a commercial DC-DC converter was built to verify this technique. Measurement results show by frequency-hopping between eight frequencies, the maximum radio frequency spur can be reduced by more than 11 dB.
Structure and Mechanical Properties of Resistance Arteries in Hypertension (2000)

Abnormalities of resistance arteries may play a role in the pathogenesis and pathophysiology of hypertension in experimental animals and humans. Vessels that, when relaxed, measure <400 microm in lumen diameter act as the major site of vascular resistance and include a network of small arteries (lumen approximately 100 to 400 microm) and arterioles (<100 microm). Because increased peripheral resistance is generated by a narrowed lumen diameter, significant effort has been focused on determining the mechanisms that reduce lumen size. Three important vascular components are clearly involved, including alterations of vascular structure, mechanics (stiffness), and function. Structural abnormalities comprise a reduced lumen diameter and thickening of the vascular media, resulting in an increased media-lumen ratio. Changes in the mechanical properties of an artery, particularly increased stiffness, may also result in a reduced lumen diameter. These vascular abnormalities may be caused or influenced by the expression and/or topographic localization of extracellular matrix components, such as collagen and elastin, and by changes in cell-extracellular fibrillar attachment sites, such as adhesion molecules like integrins. This article discusses the abnormalities of resistance arteries in hypertension and reviews the evidence suggesting an important role for adhesive and extracellular matrix determinants.
Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure (2004)

In the present study, we have investigated whether the peripheral cholinergic abnormalities that we have reported previously [Spence, Khan and Belch (2000) Am. J. Med. 108, 736-739] in patients with chronic fatigue syndrome (CFS) are also present in those with Gulf War syndrome (GWS) and agricultural workers exposed to organophosphate pesticides, where cholinesterase inhibition is specifically implicated. We also looked at whether these abnormalities might be due to a reduction in the activity of cholinesterase expressed on the vascular endothelium. We used laser Doppler imaging to measure the forearm skin blood flow responses to iontophoresis of acetylcholine and of methacholine (which is resistant to breakdown by cholinesterase) in patients with CFS, GWS and those with a history of ill health after definite organophosphate exposure, as well as in matched healthy controls. The response to acetylcholine was significantly higher in patients with CFS than in controls ( P =0.029, repeated-measures ANOVA), but was normal in those with GWS and those exposed to organophosphates. The methacholine response was higher than the acetylcholine response in all patient groups except for those with CFS, where there was no difference between the responses. Although there are many clinical similarities between these three illnesses, our results indicate peripheral cholinergic abnormalities in the vascular endothelium of only patients with CFS, suggesting that this syndrome has a different aetiology, which might involve inhibition of vascular cholinesterase.
Exponential upper bounds via martingales for multiplexers with Markovian arrivals (1994)

We obtain explicit upper bounds in closed form for the queue length in a slotted time FCFS queue in which the service requirement is a sum of independent Markov processes on the state space {0, 1}, with integral service rate. The bound is of the form [queue length for any where c < 1 and y > 1 are given explicitly in terms of the parameters of the model. The model can be viewed as an approximation for the burst-level component of the queue in an ATM multiplexer. We obtain heavy traffic bounds for the mean queue length and show that for typical parameters this far exceeds the mean queue length for independent arrivals at the same load. We compare our results on the mean queue length with an analytic expression for the case of unit service rate, and compare our results on the full distribution with computer simulations.
X-ray K-edge analysis of drain lines in Wilhelm Hall, Ames Laboratory (1999)

From August 12--27, 1998 X-ray K-edge measurements were made on drain lines in seven rooms in Wilhelm Hall, Ames Laboratory. The purpose of these measurements was to determine the extent of thorium (and other heavy metal) contamination inside these pipes. The K-edge method is a noninvasive inspection technique that can provide accurate quantification of heavy metal contamination interior to an object. Of the seven drain lines inspected, one was found to have no significant contamination, three showed significant thorium deposits, two showed mercury contamination, and one line was found to contain mercury, thorium and uranium. The K-edge measurements were found to be consistent with readings from hand-held survey meters, and provided much greater detail on the location and amount of heavy metal contamination.
Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy (2010)

Obstructive nephropathy is characterized by an inflammatory state in the kidney, that is promoted by cytokines and growth factors produced by damaged tubular cells, infiltrated macrophages and accumulated myofibroblasts. This inflammatory state contributes to tubular atrophy and interstitial fibrosis characteristic of obstructive nephropathy. Accumulation of leukocytes, especially macrophages and T lymphocytes, in the renal interstitium is strongly associated to the progression of renal injury. Proinflammatory cytokines, NF-kappaB activation, adhesion molecules, chemokines, growth factors, NO and oxidative stress contribute in different ways to progressive renal damage induced by obstructive nephropathy, as they induce leukocytes recruitment, tubular cell apoptosis and interstitial fibrosis. Increased angiotensin II production, increased oxidative stress and high levels of proinflammatory cytokines contribute to NF-kappaB activation which in turn induce the expression of adhesion molecules and chemokines responsible for leukocyte recruitment and iNOS and cytokines overexpression, which aggravates the inflammatory response in the damaged kidney. In this manuscript we revise the different events and regulatory mechanisms involved in inflammation associated to obstructive nephropathy.
A low-distortion and wide dynamic range CMOS imager for wireless capsule endoscopy (2008)

A low-distortion and wide dynamic range (DR) CMOS imager for wireless capsule endoscopy is designed in a 0.35um CMOS process. The new pixel circuit can expand the DR, and improve the signal-to-noise ratio (SNR) at the same time, with a partial pixel-level digitization scheme. The new pixel is also designed to enable digital self-calibration to compensate for the analog non-idealities in the pixel circuit, so as to suppress the distortion. With a digital signal processor (DSP) decoder at the receiver side, low distortion and wide DR image can be recovered. SPICE simulation results show that SNDR of the recovered image can reach 61.26dB after calibration. The hardware cost of the decoder is moderate.
Quantifying the energy cost of data movement for emerging smart phone workloads on mobile platforms (2014)

In portable computing systems like smartphones, energy is generally a key but limited resource where application cores have been proven to consume a significant part of it. To understand the characteristics of the energy consumption, in this paper, we focus our attention on the portion of energy that is spent to move data to the application core's internal registers from the memory system. The primary motivation for this focus comes from the relatively higher energy cost associated with a data movement instruction compared to that of an arithmetic instruction. Another important factor is the distributive computing nature among different units in a SoC which leads to a higher data movement to/from the application cores. We perform a detailed investigation to quantify the impact of data movement on overall energy consumption of a popular, commercially-available smart phone device. To aid this study, we design micro-benchmarks that generate desired data movement patterns between different levels of the memory hierarchy and measure the instantaneous power consumed by the device when running these micro-benchmarks. We extensively make use of hardware performance counters to validate the micro-benchmarks and to characterize the energy consumed in moving data. We take a step further to utilize this calculated energy cost of data movement to characterize the portion of energy that an application spends in moving data for a wide range of popular smart phone workloads. We find that a considerable amount of total device energy is spent in data movement (an average of 35% of the total device energy). Our results also indicate a relatively high stalled cycle energy consumption (an average of 23.5%) for current smart phones. To our knowledge, this is the first study that quantifies the amount of data movement energy for emerging smart phone applications running on a recent, commercial smart phone device. We hope this characterization study and the insights developed in the paper can inspire innovative designs in smart phone architectures with improved performance and energy efficiency.
Frontier molecular orbital theory of cycloaddition reactions (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFrontier molecular orbital theory of cycloaddition reactionsKendall N. HoukCite this: Acc. Chem. Res. 1975, 8, 11, 361–369Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/ar50095a001https://doi.org/10.1021/ar50095a001research-articleACS PublicationsRequest reuse permissionsArticle Views5001Altmetric-Citations703LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Renal Extraction of p-Aminohippurate in the Aged Individual (1951)

Journal Article The Renal Extraction of p-Aminohippurate in the Aged Individual Get access John H. Miller, John H. Miller Section on Gerontology Baltimore City HospitalsBaltimore 24, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Roger K. McDonald, Roger K. McDonald Search for other works by this author on: Oxford Academic PubMed Google Scholar Nathan W. Shock Nathan W. Shock Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Gerontology, Volume 6, Issue 3, July 1951, Pages 213–216, https://doi.org/10.1093/geronj/6.3.213 Published: 01 July 1951 Article history Accepted: 19 December 1950 Published: 01 July 1951
A Descriptive and Comparative Study of Physical and Performance Characteristics of NCAA Division II and Division III Softball Players. (2009)

Another family with X linked muscular dystrophy affecting particularly the humeral and tibial muscles is described. Cardiomyopathy in the eldest male necessitated the insertion of a pacemaker.
La medición de la eficiencia técnica mediante redes neuronales:: un modelo en valor añadido para la educación (2002)

El objetivo principal de esta comunicacion es presentar una metodologia para la medicion de la
eficiencia tecnica con la que operan las escuelas que gestionan el gasto publico educativo no
universitario. Para este fin, se propone un modelo en valor anadido que descuente las caracteristicas
individuales y familiares del alumno del valor realmente anadido por los factores productivos controlables
por la escuela. Dadas sus especiales caracteristicas usaremos redes neuronales artificiales para descontar
las caracteristicas del alumno de su resultado final. La eficiencia de cada escuela, asi como la importancia
de cada factor productivo sobre los distintos outputs en valor anadido, clave para la toma de decisiones
publicas, seran analizadas en una segunda etapa a partir del uso de fronteras estocasticas.
Influence of Spinning Dope Additives and Spin Bath Temperature on the Structure and Physical Properties of Acrylic Fibers (1989)

We have studied the effect of spinning dope additives and spin bath temperatures on the structure and properties of wet spun acrylic fibers. The dope additives were secondary cellulose acetate, polyvinyl pyrrolidone, polyvinyl acetate, and glycerol. Amounts of 5% (w/w) of each of these were added to the spinning dope of acrylonitrile vinyl acetate sodium methallyl sulphonate (92.7:7.0:0.3 by wt) terpolymer, and wet spun using 45:50 (v/v) of dimethyl acetamide : water, varying the spin bath temper ature from 10 to 60°C. Fibers with 5% secondary cellulose acetate as an additive exhibited low density values, highest moisture regain (2.6% against 1.6% of the parent acrylic fiber), and a three- to four-fold increase in water retention values. The tenacity was greatest in fibers with 5% polyvinyl acetate, added and spun at a 45°C spin bath temperature. We also studied the microstructure of the protofibers and the final fibers using both optical and elecqon microscopy for a better understanding of the effect of spin bath temperature on physicomechanical properties.
Characterization of ferrite and silicon carbide based microwave absorber using FSS structures at X-band (2005)

In this paper the experimental result of microwave absorber with a single layer coating of ferrite and sil icon carbide (SiC) based paint for X-band is presented. Samples of M-type hexagonal ferrite powder [Ba(MnTi) 18Fe8.40 191 has been developed by dry attrition and sintering process. These developed ferrite powder and SiC powder have been mixed in epoxy resins to form a microwave absorbing paint. This paint was coated on aluminum sheet for absorption studies. The frequency
Intelligent Garbage Collection Policy Based on I/O Workload Prediction for NAND Flash-based Storage Devices (2017)

NAND flash memory exhibits a large number of advantages such as high random access performance, small size, high reliability, and strong shock resistance, it has been widely used as the dominant storage device for consumer electronics.However, NAND flash memory uses an out-of-place update scheme to solve its erase-before-write hardware constraint and then garbage collection operations should be performed to reclaim invalid pages that are incurred by its out-of-place update scheme.Garbage collection operations usually incur high garbage collection overhead and shorten the lifetime of NAND flash memory.In this case, this paper proposes an intelligent garbage collection policy based on the I/O workload prediction for NAND flash-based storage devices.The proposed intelligent garbage collection policy adopts an improved exponentially weighted moving average method to predict the I/O workload and determines the number of victim blocks that should be reclaimed.In order to lower the degree of wear leveling for NAND flash memory, the proposed intelligent garbage collection policy first reclaims young victim block candidates with low erase count.A series of experiments are conducted with real traces on a commercial smart phone and experimental results show that our proposed intelligent garbage collection policy is superior to previous garbage collection policies in terms of the number of copy operations, the number of erase operations, the number of erase operations, the energy consumption, and the degree of wear leveling.