gebhart/patrepeval huggingface dataset:
Response of Rat Thyroid Oxidative Enzymes to TSH (1966)

Injected bovine TSH caused an increase in activity per mg protein of TPNHcytochrome c reductase, isocitric dehydrogenase, glucose 6-phosphate dehydrogenase, and DPNHDPIP reductase by 24 hr, and an increased total gland content of these enzymes at 72 hr. Gland weight, protein content, RNA, DPNH-cytochrome c reductase, and cytochrome c oxidase increased by 72 hr but the changes were not significant at the p <.O5 level. Prior T4 administration diminished all these enzyme activities. The changes are thought to be caused by 1) proteolysis with a reduction in nonenzymatic protein, 2) a possible shift of cell metabolism to biosynthetic activities, and 3) cell growth. The responses in respiratory enzyme activities do not occur as rapidly as do other TSH-mediated changes in cell metabolism and are most likely secondary to TSH-induced changes in energy utilization. (Endocrinology78: 1032, 1966)
Absorption and Resonance Raman Investigations of Ligand Rotation and Nonplanar Heme Distortion in Bis-Base Low-Spin Iron(II)−Tetrakis(<i>o</i>-pivalamidophenyl)porphyrin Complexes (2003)

The absorption and resonance Raman (RR) spectra of the bis-N-methylimidazole, bis-1,5-dicyclohexylimidazole, and bis-pyridine complexes of the meso-alphaalphabetabeta and meso-alphabetaalphabeta atropisomers of Fe(II)-tetrakis(o-pivalamidophenyl)porphyrins (Fe(II)TpivPP) were obtained in methylene chloride. The different spatial arrangements of the o-pivalamide pickets in these two Fe(II)TpivPP compounds are expected to control the absolute and relative positions of the axial ligand rings with respect to the Fe-N(pyrrole) bonds. In particular, the spectroscopic data obtained for the bis-N-methylimidazole and bis-dicyclohexylimidazole complexes of the Fe(II)[alphabetaalphabeta-TpivPP] derivative showed the most important differences. Redshifts of the B and Q absorption bands (+ 4-5 nm) as well as an upshift of the low frequency nu(8) RR mode (+ 5 cm(-)(1)) were observed. No shift of the skeletal high frequency modes was detected. These spectral effects were associated with a change in relative position of the axial imidazole rings from nearly parallel in the bis-N-methylimidazole complex to nearly perpendicular in the bis-dicyclohexylimidazole complex. On the basis of stereochemical considerations as well as previous spectroscopic investigations, the data were interpreted in terms of change in porphyrin structure from planar to saddled. Complementing to a parallel study on bis-base Fe(II) "basket handle" porphyrin complexes, this spectroscopic investigation provides an additional means to distinguish planar, ruffled, and saddled conformations for ferrous hemes included in proteins.
Studies of the Physicochemical and Enzymatic Properties of Papaya Lysozyme (1967)

Abstract Papaya lysozyme, purified by ion exchange chromatography on IRC-50, has been investigated with respect to physicochemical and enzymatic properties. In agreement with earlier findings, it was found that papaya lysozyme has a molecular weight of about 25,000 and that glycine is its sole amino-terminal residue. Molecular weight determinations in dissociating solvents indicate that the molecule consists of a single polypeptide chain. Papaya lysozyme lyses Micrococcus lysodeikticus cell walls at a rate one-third of that exhibited by egg white lysozyme; however, it displays a chitinase activity toward tetra-N-acetyl-d-glucosamine 400 times that of the egg white enzyme. No involvement of tryptophan residues in the active site of papaya lysozyme could be demonstrated.
Kinetic analysis of the effects of glycosaminoglycans and lipoproteins on urokinase-mediated plasminogen activation (1991)

The glycosaminoglycans (GAGs) heparin, heparan sulphate and chondroitin 6-sulphate stimulate the rate of urokinase activation of human plasminogen. Kinetic analysis of plasminogen activation demonstrates that heparin, heparan sulphate and chondroitin 6-sulphate increased the catalytic rate (Kcat) by 5.3-, 3.5- and 2.5-fold respectively. These stimulatory GAGs had no effect on the affinity of urokinase for plasminogen, since the Km of the reaction is unaltered by the GAGs. The GAGs may enhance the rate of plasminogen activation through an interaction with the catalytic domain of the urokinase, with dissociation constants of approx. 30 nM. Additionally, the lipoproteins, lipoprotein (a) [Lp(a)] and low-density lipoprotein (LDL) inhibit heparin and heparan sulphate stimulation of plasmin formation. Lp(a) is a competitive inhibitor (Kic 20 nM) and LDL is a mixed inhibitor of heparin-enhanced urokinase-mediated plasminogen activation (Kic 24 nM and Kiu 60 nM). These inhibition constants correlate with physiological concentrations of these lipoproteins. These data suggest that these GAGs and lipoproteins may play an important role in vivo in regulating urokinase-mediated plasmin formation.
Backbone <sup>15</sup>N relaxation analysis of the N‐terminal domain of the HTLV‐I capsid protein and comparison with the capsid protein of HIV‐1 (2003)

Human T-cell leukemia virus type 1 (HTLV-I) is an oncogenic retrovirus that exhibits specific tropism for human T-cells. The capsid (CA) proteins of retroviruses share highly conserved secondary and tertiary structures. However, they can form quaternary structures (assembled cores) that are conical (e.g., the lentivirus subgroup, including HIV) or spherical (e.g., the oncovirus subgroup, including HTLV). The intrinsic features that drive these differences are not understood. So far, only structural studies have been used as a basis for comparison. Dynamics may play a role in particle formation. High-resolution nuclear magnetic resonance (NMR) (15)N relaxation data (T(1), T(1rho), and NOE) have been used to characterize the backbone dynamics of the N-terminal domain (NTD) of the oncovirus HTLV-I and to compare with the CA NTD of HIV-1. Large variations in the (15)N heteronuclear NOEs and transversal relaxation rates for individual residues are consistent with the bundle RMSD of the previously calculated NMR structures. The beta-hairpin and CyP-A loop exhibit different mobility in HTLV-I and HIV-1. The overall hydrodynamic property of the HTLV-I capsid NTD is quite distinct from the HIV-1.
Oligoclonal immunoglobulins in HIV-antibody-positive serum. (1988)

Journal Article Oligoclonal immunoglobulins in HIV-antibody-positive serum. Get access D B Taichman, D B Taichman Dept. of Pathol. and Lab. Med., Hosp. Univ. of Pennsylvania, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar K Bayer, K Bayer Dept. of Pathol. and Lab. Med., Hosp. Univ. of Pennsylvania, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar M Senior, M Senior Dept. of Pathol. and Lab. Med., Hosp. Univ. of Pennsylvania, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar D B Goodman, D B Goodman Dept. of Pathol. and Lab. Med., Hosp. Univ. of Pennsylvania, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar L J Kricka L J Kricka Dept. of Pathol. and Lab. Med., Hosp. Univ. of Pennsylvania, Philadelphia 19104 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 34, Issue 11, 1 November 1988, Page 2377, https://doi.org/10.1093/clinchem/34.11.2377 Published: 01 November 1988
Main problems and proposed solutions to induction machine drive control of multisystem locomotive (2009)

This project was motivated by demand of our industrial partners for proposal of prospective control of induction machine drive for new generation of multisystem locomotives. This paper presents proposed drive control including specifically optimized PWM algorithms. Designed control is based on rotor flux oriented vector control in Cartesian coordinates which is unusually operated due to employed synchronized PWM in whole speed range. Commutation angles for developed synchronous PWM have been found by multi-criteria optimization where the most important measure was reduction of danger frequency components of trolley-wire current which can harm function of railway safety systems. Proper function of proposed control is verified by tests on designed small-scale prototype of locomotive drive. Selected results of extensive experimental study into trolley-wire current spectrum and related drive interaction with railway safety systems, which is one of the most serious problems of modern locomotives and high-speed trains, are considerable part of this paper.
Untersuchung und Modulation kortikaler Inhibition mittels transkranieller Magnetstimulation (2017)

Zusammenfassung: Die Transkranielle Magnetstimulation (TMS) ist eine nicht-invasive Hirnstimulationstechnik, die zu diagnostischen, therapeutischen und wissenschaftlichen Zwecken in der Neurologie und Psychiatrie eingesetzt wird. Sie beruht auf dem physikalischen Grundprinzip der elektromagnetischen Induktion und ermöglicht die lokale Aktivierung kortikaler Areale durch den intakten Schädel des wachen Probanden oder Patienten. Eine sogenannte repetitive TMS (rTMS) kann zu anhaltenden Veränderungen der kortikalen Erregbarkeit führen. Die TMS stellt somit einen vielversprechenden Ansatz zur nicht-invasiven Untersuchung neuronaler Netzwerke, sowie deren lang anhaltender Beeinflussung dar. Trotz ihres mittlerweile breiten klinischen Einsatzes, sind die zellulären und molekularen Wirkmechanismen der TMS noch nicht genau geklärt. Etablierte Therapiekonzepte gehen von einer Wiederherstellung einer krankheitsbedingt veränderten kortikalen Erregbarkeit aus, die auf einer „Langzeit-Potenzierung“ oder „Langzeit-Depression“ erregender Synapsen beruhen könnte. Tatsächlich zeigen tierexperimentelle Studien, dass die rTMS in der Lage ist, anhaltende Veränderungen erregender Neurotransmission zu bewirken. Es bleibt allerdings unklar, auf welche Weise synaptische Veränderungen, die durch eine elektromagnetische Aktivierung der Hirnrinde bewirkt werden und demnach nicht kontext- oder verhaltensspezifisch sind, einen positiven Einfluss auf Hirnfunktionen haben. Neuere Befunde deuten nun darauf hin, dass die rTMS in der Lage ist, neben erregenden auch hemmende neuronale Netzwerke anhaltend zu beeinflussen. So gelang es nachzuweisen, dass 10 Hz repetitive Magnetstimulation zu einer kalziumabhängigen „Langzeit-Depression“ inhibitorischer GABAerger Synapsen führt. Da der Verminderung hemmender Neurotransmission (=Disinhibition) eine wichtige Rolle bei der Bahnung assoziativer Plastizität erregender Synapsen beigemessen wird, ist davon auszugehen, dass rTMS-induzierte Disinhibition die Ausbildung kontext- und verhaltensspezifischer synaptischer Veränderungen begünstigt. Das Modell der
Methylmalonic Acidemia, Cobalamin C Type, Presenting With Cutaneous Manifestations (1997)

An erosive, desquamating dermatitis with histopathologic characteristics resembling acrodermatitis enteropathica may be a presenting sign in cobalamin C methylmalonic acidemia, even in the absence of long-standing nutritional restrictions or deficiency.
Prevention of Chemotherapeutic Effects of 4-Amino-N10-Methyl-Pteroylglutamic Acid on Mouse Leukemia by Pteroylglutamic Acid. (1949)

The effect of 4-amino-N10-methyl-pteroylglutamic acid in prolonging the survival time of mice with transplanted leukemia Ak 4 can be blocked almost completely by prior administration of 10 to 20 times as much pteroylglutamic acid and, to a lesser degree, by 17 to 125 times as much pteroyltri-glutamic acid.
Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets (2019)

Chronic hepatitis viral infection, alcoholic intoxication, and obesity cause liver fibrosis, which progresses to decompensated liver cirrhosis, a disease for which medical demands cannot be met. Since there are currently no approved anti-fibrotic therapies for established liver fibrosis, the development of novel modalities is required to improve patient prognosis. In this study, we clarified the anti-fibrotic effects of cell sheets produced from human bone marrow-derived mesenchymal stem cells (MSCs) incubated on a temperature-sensitive culture dish with the chemical compound IC-2. Orthotopic transplantation of IC-2-engineered MSC sheets (IC-2 sheets) remarkably reduced liver fibrosis induced by chronic CCl<sub>4</sub> administration. Further, the marked production of fibrolytic enzymes such as matrix metalloproteinase (MMP)-1 and MMP-14, as well as thioredoxin, which suppresses hepatic stellate cell activation, was observed in IC-2 sheets. Moreover, the anti-fibrotic effect of IC-2 sheets was much better than that of MSC sheets. Finally, knockdown experiments revealed that MMP-14 was primarily responsible for the reduction of liver fibrosis. Here, we show that IC-2 sheets could be a promising therapeutic option for established liver fibrosis.
Effect of Ti Content on Hydrogen Storage Properties of Amorphous MgNi Alloy (2010)

Cycle capacities of Amorphous Mg-Ni alloys declined so fast therefore they can’t be used practically. In this paper，the influence of adding Ti on the discharge capacity and cycle stability of the alloys were investigated. Amorphous Mg1-xTixNi (x=0, 0.1, 0.2, 0.3) alloy powder was prepared successfully by mechanical alloying (MA). X-ray diffraction (XRD) results show that MgNi alloy formed completely amorphous phase after ball milling with 15h. But for Mg1-xTixNi (x=0.1, 0.2, 0.3) alloy, it took 23h. It can be concluded that Ti partial substituting Mg would decrease the amorphous phase forming ability of Mg-Ni based alloy. Compared with amorphous MgNi alloy, the maximal discharge capacities of Mg1-xTixNi (x=0.1, 0.2, 0.3) alloy were decreased slightly, but the cycle stabilities were significantly enhanced. Mg0.9Ti0.1Ni alloy showed the largest discharge capacity and the best cycle stability.
Estratégias de manejo da palha de azevém para cultivo do arroz irrigado em sucessão (2013)

A adoção de sistemas de rotação e sucessão de culturas é um dos pré-requisitos fundamentais para sustentabilidade dos sistemas de produção agrícola. Diante disso, o objetivo deste trabalho foi avaliar os efeitos de época de dessecação do azevém e de dose de adubação nitrogenada, aplicada na semeadura do arroz irrigado em sucessão, como estratégias para viabilizar o uso dessa sucessão em áreas de cultivo de arroz irrigado. O experimento foi conduzido no campo em dois anos agrícolas (2008/09 e 2009/10), em Cachoeirinha, RS, em um Gleissolo Háplico Ta distrófico típico. Utilizou-se o delineamento de blocos casualizados, em parcelas subdivididas, com três repetições. Os tratamentos foram constituídos de quatro épocas de dessecação do azevém (90, 70, 50 e 30 dias antes da semeadura do arroz, no primeiro ano; e 49, 34, 19 e 6, no segundo ano), de cinco sistemas de manejo da adubação nitrogenada no arroz irrigado, obtidos pela combinação de quatro doses de N na semeadura (0, 10, 20 e 40 kg ha-1) e de quatro doses de N em cobertura (150, 140, 130 e 110 kg ha-1), totalizando 150 kg ha-1, e de uma testemunha sem aplicação de N, durante todo o ciclo da cultura. A presença de palha de azevém com as plantas mantidas de pé não prejudica o estabelecimento inicial de plantas de arroz cultivado em sucessão. O rendimento de grãos de arroz irrigado cultivado em sucessão ao azevém não é influenciado pela época de dessecação de azevém e pela dose de N aplicada em semeadura.
Preparation and Crystal Structures of Solid Solutions of Alkaline-earth Monoferrites (1964)

アルカリ土類金属モノフェライト,MFe2O4(M=バリウム,ストロンチウム,カルシウム)はそれぞれ異なった結晶構造をもち,固溶体は形成され難いが,Ba(Sr1-xCax)Fe4O3の化学組成の狭い領域に六方晶系の結晶相が存在していることを見つけた。Ba・(Sr1-xCax)Fe4O3の格子定数はκの増加にともなって連続的に減少するが,6軸の変化はα軸に比較して大きい。また(001)回折線が現われ,その回折強度はXの増加とともに増す。これらの結果から固溶体はBaFe2O4類似の構造をもち,しかも6軸に沿ってバリウムとストロンチウム,カルシウムの規則配列をとっていることが推論される。他方Ba(Al1-xFex)2O4ではx<0.9の範囲で六方晶系の固溶休が得られる。BaFe2O4側ではc軸の異常な減少が見られるが,それは直接BaFe2O4のX線回折線の分裂,超格子に基づく回折線の出現に対応する。
Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia (2015)

Idiopathic CD4 lymphopenia (ICL) is a rare syndrome defined by low CD4 T-cell counts (<300/µL) without evidence of HIV infection or other known cause of immunodeficiency. ICL confers an increased risk of opportunistic infections and has no established treatment. Interleukin-7 (IL-7) is fundamental for thymopoiesis, T-cell homeostasis, and survival of mature T cells, which provides a rationale for its potential use as an immunotherapeutic agent for ICL. We performed an open-label phase 1/2A dose-escalation trial of 3 subcutaneous doses of recombinant human IL-7 (rhIL-7) per week in patients with ICL who were at risk of disease progression. The primary objectives of the study were to assess safety and the immunomodulatory effects of rhIL-7 in ICL patients. Injection site reactions were the most frequently reported adverse events. One patient experienced a hypersensitivity reaction and developed non-neutralizing anti-IL-7 antibodies. Patients with autoimmune diseases that required systemic therapy at screening were excluded from the study; however, 1 participant developed systemic lupus erythematosus while on study and was excluded from further rhIL-7 dosing. Quantitatively, rhIL-7 led to an increase in the number of circulating CD4 and CD8 T cells and tissue-resident CD3 T cells in the gut mucosa and bone marrow. Functionally, these T cells were capable of producing cytokines after mitogenic stimulation. rhIL-7 was well tolerated at biologically active doses and may represent a promising therapeutic intervention in ICL. This trial was registered at www.clinicaltrials.gov as #NCT00839436.
Mannan binding lectin in febrile adults: no correlation with microbial infection and complement activation (2003)

The results argue against a predominant role for the MBL pathway of complement activation and a deficiency of MBL predisposing to serious and invasive microbial infection in non-selected adults.
Carbon-carbon and carbon-nitrogen bond formation mediated by ruthenium(II) complexes: synthesis of (1H)-isoquinolinium derivatives (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-carbon and carbon-nitrogen bond formation mediated by ruthenium(II) complexes: synthesis of (1H)-isoquinolinium derivativesHendrikus C. L. Abbenhuis, Michel Pfeffer, Jean Pascal Sutter, Andre de Cian, Jean Fischer, Hong Li Ji, and John H. NelsonCite this: Organometallics 1993, 12, 11, 4464–4472Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/om00035a034https://doi.org/10.1021/om00035a034research-articleACS PublicationsRequest reuse permissionsArticle Views596Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: A NEW IRON/SULFUR CLUSTER WITH THE (FE6S6)3+ PRISMATIC CORE AND P‐METHYLPHENOLATE TERMINAL LIGANDS. THE SYNTHESIS, STRUCTURE, AND PROPERTIES OF (ET4N)3FE6S6(OC6H4‐P‐CH3)6 (1985)

Abstract Der hydrolyseempfindliche Titelcluster (I) wird durch Reaktion von ′ (Et 4 N) 3 (Fe 6 S 6 Cl 6 ) mit dem Na‐Salz von p‐Kresol in Acetonitril bei Raumtemp. = gebildet.
IgG Subclass Profiles in Infected HIV Type 1 Controllers and Chronic Progressors and in Uninfected Recipients of Env Vaccines (2010)

We have studied IgG subclass responses to the HIV-1 proteins gp120, gp41, p24, and Tat in individuals who control their infection without using antiretroviral drugs (HIV-1 controllers; HC) or who progress to disease (chronic progressors; CP). We also measured IgG subclass titers to gp120 in vaccinated individuals. In all cases, the IgG1 subclass dominated the overall response to each antigen. The only IgG titer that differed significantly between the HC and CP groups was to the p24 Gag protein, which was higher in the HC group. IgG1 titers to both p24 and gp120 were significantly higher in the HC group, and IgG3 anti-gp120 antibodies, although rare, were detected more frequently in that group than in CP. Overall, significantly more patients had IgG2 antibodies to gp120 than to gp41. Antibodies to other IgG subclasses were infrequent and their frequency or titers did not differ between the two patient groups. Anti-gp41 and anti-Tat responses also did not correlate with immune control, and anti-Tat antibodies were infrequently detected. Although we found isotypic differences in IgG responses to HIV-1 antigens among vaccinees and the HC and CP individuals, there were no indications of differential T(H)1:T(H)2 polarization between the different groups.
Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) α or ERβ in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors (2004)

Estrogens exert many important effects in bone, a tissue that contains both estrogen receptors alpha and beta (ERalpha and ERbeta). To compare the actions of these receptors, we generated U2OS human osteosarcoma cells stably expressing ERalpha or ERbeta, at levels comparable with those in osteoblasts, and we characterized their response to 17beta-estradiol (E2) over time using Affymetrix GeneChip microarrays to determine the expression of approximately 12,000 genes, followed by quantitative PCR verification of the regulation of selected genes. Of the approximately 100 regulated genes we identified, some were stimulated by E2 equally through ERalpha and ERbeta, whereas others were selectively stimulated via ERalpha or ERbeta. The E2-regulated genes showed three distinct temporal patterns of expression over the 48-h time course studied. Of the functional categories of the E2-regulated genes, most numerous were those encoding cytokines and factors associated with immune response, signal transduction, and cell migration and cytoskeleton regulation, indicating that E2 can exert effects on multiple pathways in these osteoblast-like cell lines. Of note, E2 up-regulated several genes associated with cell motility selectively via ERbeta, in keeping with the selective E2 enhancement of the motility of ERbeta-containing cells. On genes regulated equally by E2 via ERalpha or ERbeta, the phytoestrogen genistein preferentially stimulated gene expression via ERbeta. These studies indicate both common as well as distinct target genes for these two ERs, and identify many novel genes not previously known to be under estrogen regulation.