gebhart/patrepeval huggingface dataset:
Fabrication and characterization of effective medium meta-dielectrics. (2006)

The purpose of this thesis is driven by the performance and manufacturability of various electromagnetic passive components. These devices are unique in their needs for seemingly arbitrary dielectric properties in seemingly arbitrary spatial locations. The desired properties may or may not exist in conventional material and their corresponding spatial location may not be realizable using conventional fabrication techniques. This thesis addresses these needs by exploiting the effective medium behavior of porous dielectrics. The dielectric properties of porous Titania were characterized for three different pore morphologies: partially sintered pores, 15 micron spherical pores, and 50-70 micron cylindrical pores. Reduction in the dielectric constant, k, was achieved tailoring the volume fraction porosity. The decreasing k vs. porosity behavior is modeled well by the Bruggeman power law independent of pore morphology. Porous dielectric loss behavior is found to more complex. Porous dielectric loss depends on both the inherent loss of the base dielectric and on the pore morphology. Increasing pore size for a given volume fraction porosity decreases dielectric loss. A spatially variable embedded dielectric resonator is fabricated from monolithic Titania. This device exploits effective medium dielectrics by locally controlling the porosity. An artificially anisotropic dielectric is fabricated from Titania with oriented porosity. Using 37% porosity, the dielectric anisotropy is greater than 9:1. A new powder processing method is presented that is capable of realizing complex spatially variable dielectrics or functionally graded ceramics. This new process is called dry powder deposition or DPD. It readily achieves a 3mm level of granularity while maintaining a geometrical tolerance of 0.6% for a 40 mm part size. DPD is applied to the fabrication of a UHF antenna substrate that has a very high degree of dielectric texturization.
Novel method of all-optical OR operation using semiconductor optical amplifier Mach-Zehnder interferometers (2010)

We propose a novel method of all-optical OR operation using semiconductor optical amplifier Mach-Zehnder interferometers. We demonstrate all-optical OR operation at 42.8 Gb/s using a hybrid photonic integrated device.
Eigenvalue sensitivity analysis of GTO-CSI induction machine drives (1994)

The importance of eigenvalue sensitivity analysis in the design of drive systems is shown. It is demonstrated that the eigenvalue sensitivity can be used to identify an association between the eigenvalues and the parameters of the system and that it can provide useful guidance in selecting the system parameters. Eigenvalue sensitivity can also be used to find possible sources of instability and to determine the most sensitive parameters. The insight into the behavior of the drive system which can be gained from a sensitivity analysis provides valuable guidance in system analysis and design. An 800 HP GTO-CSI induction machine drive is used as an example for the sensitivity analysis. The results obtained are verified by both frequency and time domain simulation methods.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optical evidences of assisted tunneling in a biased double quantum well structure (1989)

Experimental evidences of electron and hole resonant tunnelings are obtained in a biased double quantum well system using optical methods. Calculations of the defect-induced tunneling rates are performed and compared with experiments.
Gender-Specific Relationship Between Serum Uric Acid Level and Atrial Fibrillation Prevalence (2011)

Reflecting the composite of various cardiovascular risk factors, serum uric acid level was apparently associated with AF prevalence. The independent association in women might imply some sex-specific mechanisms. The results should be confirmed in prospective studies.
Dynamics of the Acoustic Reflex: Phenomenological Aspects (1964)

The acoustic reflex was studied by measuring the variations in the mechanical-input impedance to the ears of six normal human subjects. The auditory system was stimulated by wide-band noise at various intensity levels. The static magnitude and phase characteristics of the response were obtained at several frequencies. It was shown that reflex activity results in an increase in the magnitude and a decrease in the phase lag of the ear's input impedance. The system dynamics were studied with step stimuli. It was shown that at stimulus onset both the latency and speed of the response are related to stimulus magnitude. With higher intensities, shorter latency and faster response results. At the cessation of the stimulus, in general there was no clear functional relationship between latency and intensity. For some subjects, faster reflex relaxation occurred after low-intensity stimulation than after more-intense activity. For other subjects, there was no such clear trend. It was observed that, during prolonged stimulation with very high intensity noise, stable reflex activity resulted; but if the stimulus was weaker, then response adaptation occurred. In the vicinity of reflex threshold, the adaptation was usually quite rapid.
An Analysis of Interplanetary Space Radiation Exposure for Various Solar Cycles (1994)

The radiation dose received by crew members in interplanetary space is influenced by the stage of the solar cycle. Using the recently developed models of the galactic cosmic radiation (GCR) environment and the energy-dependent radiation transport code, we have calculated the dose at 0 and 5 cm water depth; using a computerized anatomical man (CAM) model, we have calculated the skin, eye and blood-forming organ (BFO) doses as a function of aluminum shielding for various solar minima and maxima between 1954 and 1989. These results show that the equivalent dose is within about 15% of the mean for the various solar minima (maxima). The maximum variation between solar minimum and maximum equivalent dose is about a factor of three. We have extended these calculations for the 1976-1977 solar minimum to five practical shielding geometries: Apollo Command Module, the least and most heavily shielded locations in the U.S. space shuttle mid-deck, center of the proposed Space Station Freedom cluster and sleeping compartment of the Skylab. These calculations, using the quality factor of ICRP 60, show that the average CAM BFO equivalent dose is 0.46 Sv/year. Based on an approach that takes fragmentation into account, we estimate a calculation uncertainty of 15% if the uncertainty in the quality factor is neglected.
Automatic classification of sub-microlitre protein-crystallization trials in 1536-well plates (2003)

A technique for automatically evaluating microbatch (400 nl) protein-crystallization trials is described. This method addresses analysis problems introduced at the sub-microlitre scale, including non-uniform lighting and irregular droplet boundaries. The droplet is segmented from the well using a loopy probabilistic graphical model with a two-layered grid topology. A vector of 23 features is extracted from the droplet image using the Radon transform for straight-edge features and a bank of correlation filters for microcrystalline features. Image classification is achieved by linear discriminant analysis of its feature vector. The results of the automatic method are compared with those of a human expert on 32 1536-well plates. Using the human-labeled images as ground truth, this method classifies images with 85% accuracy and a ROC score of 0.84. This result compares well with the experimental repeatability rate, assessed at 87%. Images falsely classified as crystal-positive variously contain speckled precipitate resembling microcrystals, skin effects or genuine crystals falsely labeled by the human expert. Many images falsely classified as crystal-negative variously contain very fine crystal features or dendrites lacking straight edges. Characterization of these misclassifications suggests directions for improving the method.
A New Diprenyl Coumarin and Alkaloids from the Bark of Zanthoxylum dimorphophyllum (Rutaceae) (2001)

The alkaloids chelerythrine, norchelerythrine, oxyavicine, canthine-6-one, 4,5-dihydrocanthin-6-one, and gamma-fagarine were isolated from Zanthoxylum dimorphophyllum bark, together with two coumarins, scoparone and dimoxylin. This latter is a novel compound whose structure was elucidated on the basis of its spectral data.
An analog technology integrates bipolar, CMOS, and high-voltage DMOS transistors (1984)

This paper describes the development of an analog technology that integrates bipolar, CMOS, and DMOS transistors on a single chip. The architecture of the process was chosen for its simplicity and versatility. The influence of the process variables and trade-offs in the performance of the devices have been outlined. Some key elements of DMOS and bipolar transistor behavior are discussed. The successful application of the technology to a plasma display driver has been demonstrated.
Targeting of breast cancer with non-oncology drugs – possible novel therapeutic option for triple-negative breast cancer. (2009)

Abstract Abstract #2119 Introduction: Triple-negative breast cancer (TNBC) is defined by lack of ER, and PR expression and normal HER2 expression. It is characterized by aggressive biological presentation and unfavorable outcome. It is associated with frequent lack of response to current chemotherapy agents. Recently, 392 drugged genes that serve as targets for 1557 both oncologic and non-oncologic drugs were identified from the pharmacologic database DrugBank (Lauss et al. Pharmacogenomics 2007). In this study, we compared expression levels of these known drug targets between TNBC and receptor-positive cancers. Methods: Gene expression profiles were obtained from fine needle biopsies of newly diagnosed early stage breast cancer before any therapy (n=133, MDACC dataset). Differential expression of these genes was validated in a second independent data set (n=286, Rotterdam dataset) and in a panel of cell lines (n=19). In order to assess the functional relevance of known drug targets overexpressed in TNBC we performed in vitro experiments. Cell lines were treated with various concentrations of selected drugs alone or in combination with paclitaxel. Results: We mapped 675 U133A probe sets representing 347 unique drug targets to the Affymetrix U133A Genechip. 44 drug targets were overexpressed in TNBC compared to non-TNBC in the MDACC dataset. Thirty-three of these (75%) were also overexpressed among TNBC compared to non-TNBC in the Rotterdam dataset. Glutathione-S-transferase pi (GSTpi, target of clomipramine) was the most highly and consistently overexpressed target in human TNBC and in estrogen- and HER2-receptor-negative breast cancer cell lines. The GSTpi overexpressing (and triple negative) human mammary cell line HBL-100 showed dose-dependent inhibition of growth after 144 hrs of incubation with clomipramine, whereas growth of the GSTpi-low expressing (non-triple negative) breast cancer cell lines MCF-7 and SKBR3 was not inhibited by this drug. Treatment with clomipramine did not alter sensitivity to paclitaxel in either cell line in vitro. Conclusion: Gene expression analysis indicates that targets for several known drugs are over expressed in TNBC relative to other types of breast cancers. We hypothesize that some of these drugs may influence the behavior of TNBC and may represent future therapeutic options. Further experiments are needed to fully explore the functional implications of these findings; however, our preliminary results suggest that inhibition of GSTpi with clomipramine leads to inhibition of cell growth of TNBC cell lines in vitro. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2119.
The behaviour of mitotic nuclei after transplantation to early meiotic ooplasts or mitotic cytoplasts (1997)

Summary This study evaluates the ability of the cytoplasm to determine the nature of the division cycle (meiotic or mitotic) in nuclei obtained from mitotically dividing cells. Using mouse oocytes in different stages of development two types of cytoplasm were prepared: firstly, early meiotic ooplasts were obtained by enucleation of non-matured, prophase-stage oocytes; secondly, mitotic cytoplasts were prepared by enucleation and activation of metaphase II (Mll)-stage oocytes. These two types of cytoplasts were then used in fusion experiments, in which mouse primitive type A spermatogonia (prospermatogonia) or mouse fibroblasts were used as a source of donor nuclei. While the fusion of prospermatogonia with mitotic cytoplasts resulted, as expected, in normal premature chromosome condensation (PCC) and subsequent pronuclear formation (58.1%), the majority of hybrids obtained by fusion of prospermatogonia with early meiotic ooplasts (40.3%) displayed unique morphology consisting of two sets of chromosomes organised in two spindle centres connected by microtubules. Each set of chromosomes contained the haploid (1n) number of chromosomes as revealed by chromosome analyses. The same morphology was observed also in 44.2% of hybrids in which the differentiated nuclei of fibroblasts were used as a source of donor mitotic nuclei. In both cases the hybrids were blocked at this stage with high activity of maturation promoting factor (MPF), resistant to any kind of activation and not able to undergo further development. These results suggest that the early meiotic ooplasm was able to induce the initiation of a meiosis-like reducing division in mitotic nuclei originating both from the germline cells and from more differentiated somatic cells.
Cell Growth Signaling in Fibroblasts: the Role of G-Proteins (1990)

A complete understanding of the control of mammalian cell proliferation is a very difficult task. A major problem is that we are dealing with multicellular organisms and that an immense variety of environmental signals (hormones, growth and differentiating factors, extracellular matrix) are known to influence or dictate the physiological state and behavior of the cell. The development of cell lines able to grow, to quiesce or to differentiate in response to a subset of pure hormones and growth factors in chemically defined media has considerably facilitated the study. With these in-vitro models, including cultured fibroblasts, smooth muscle cells and epithelial cells, it is possible to define key stages of the cell cycle where growth-promoting agents exert their action, and to delineate signaling pathways involved in initiation, progression or arrest of cell growth.
Possible Genetic Predisposition to Lymphedema after Breast Cancer (2012)

These provocative, albeit preliminary, findings regarding possible genetic predisposition to secondary lymphedema following breast cancer treatment warrant further attention for potential replication using larger datasets.
De la sémantique des contenus à la sémantique des structures (2002)

Ce chapitre présente un cadre unifié pour la représentation de la sémantique des documents semi-structuré. L'intégration dans les cadres normatifs existants, tant à l'ISO qu'au W3C y est présenté, ainsi qu'une application à la représentation de données terminologiques dans le cadre de la norme ISO 16642.
A modified oligostilbenoid, diptoindonesin C, from<i>Shorea pinanga</i>Scheff. (2009)

A new oligostilbenoid, diptoindonesin C, has been isolated from the tree bark of Shorea pinanga Scheff., along with the two known oligostilbenoids gnetin H and hopeaphenol, and a known coumarin scopoletin. The new oligostilbenoid was moderately active against brine shrimps Artemia salina.
Recent advances in TDFIT algorithm and its applications (2015)

In the past three years, we have concentrated on developing a time-domain finite-integration theorem (TDFIT) and applying it in practical applications. In the development of TDFIT theory, a conformal technique has been implemented to improve its accuracy. To solve complex problems much smarter, we have proposed an adaptive steady-state criterion (SSC) and a flexible Smatrix scheme. In addition, we are developing an Mpi-Openmp-Gpu (MOG) hybrid parallel technique to further accelerate TDFIT. In the aspect of application, a TDFIT-ANN (Artificial Neural Network) hybrid method is used to efficiently optimize a broadband antennas-radome system. To analyze the multipactor, we presented a TDFIT-PIC (Particle-In-Cell) hybrid algorithm. Besides, a multi-physics solution based on TDFIT is being developed to investigate the passive intermodulation.
ACOUSTICS2008/63 Experimental confirmation of negative dispersion and Bayesian inversion of multimode propagation in a bone-mimicking phantom (2008)

Previously we demonstrated using numerical simulations that negative dispersion observed in bone can result from the interference of two propagating modes, each of which exhibits positive dispersion, consistent with the Kramers-Kronig predictions. [J. Acoust. Soc. Am. 120, EL55-61 (2006)] One goal of the present study was to demonstrate this negative dispersion experimentally using the simplest example of a bone-mimicking phantom that is capable of producing two such interfering modes. An additional goal was to establish that, with the experimental data serving as input to a Bayesian approach to the inverse problem [J. Acoust. Soc. Am. 121, EL8-15 (2007)], reliable estimates of the underlying properties of the bone-mimicking phantom could be obtained from the measured signals. The phantom consisted of a flat and parallel PlexiglasTM plate into which a step discontinuity was milled. The phase velocity and attenuation coecient (3 to 7 MHz) of the phantom were measured with a 0.25-inch piezoelectric receiver and calculated using both broadband and narrowband data. Negative dispersion was observed at specific spatial locations near the step where the attenuation coecient rose approximately linearly with frequency. Results demonstrate that interference between modes can result in negative dispersion and that Bayesian inversion can yield underlying material properties.
ChemInform Abstract: Sterics versus Electronics: Regioselective Cross‐Coupling of Polybrominated Thiophenes. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Organic Phase for Aluminum Batteries (1999)

The electrochemical behavior of an anode in organic electrolytes was investigated. Common contemporary electrolytes for batteries were selected, based on their activity toward anodic dissolution. Significant improvement (anodic shift) of by up to occurs in several electrolytes, and can exhibit efficient coulombic oxidation of aluminum. Enhanced electrolytes include (TEA), and in (BLA) and acetonitrile (ACN) solvents, forming solutions such as TEA/BLA, TEA/ACN, and concentration optimized . based electrolytes exhibit evidence of quasireversible activity creating possibilities for rechargeable batteries. ©1999 The Electrochemical Society
Helmintiasis intestinal en escolares de varias instituciones públicas de la parroquia La Paz del Municipio Pampán -Trujillo-Venezuela (2013)

Las helmintiasis intestinales son entidades cosmopolita presente tanto en las zonas urbanas como rurales,\nrepresentando una causa importante de morbilidad y mortalidad en el ámbito mundial, con un gran impacto\nen la salud de los niños principalmente. El presente estudio tuvo como propósito fundamental determinar la\nhelmintiasis intestinal en escolares provenientes de varias instituciones públicas de la parroquia La Paz del\nmunicipio Pampán -Trujillo-Venezuela. Se procesaron un total de 483 muestras fecales correspondientes a\nniños de ambos sexos dentro de un grupo etario comprendido entre nueve a trece años, los cuales acudieron\nal Ambulatorio Rural II de Monay por diferentes causas clínicas. Las muestras fueron analizadas a través\nde tres métodos coproparasitológicos, el examen directo con solución salina (SS) y lugol, y la técnica de\nKato-Katz. Del total de muestras examinadas, 220 (45,5%) se encontraron positivas para algún helminto.\nAscaris lumbricoides estuvo presente en el 54,5% de las muestras examinadas, seguido por Trichuri.\ntrichiura 36,5% y fi nalmente Strongyloides stercoralis estuvo presente en el 9 %. En este estudio se encontró\nun predominio del monoparasitismo sobre el poliparasitismo. Debido al alto porcentaje de los helmintos\nencontrados en este estudio es importante concientizar a los organismos competentes y a la población para\nque apliquen las medidas preventivas necesarias que permitan disminuir y evitar la prevalencia de parásitos\nintestinales en escolares de la parroquia la paz del municipio Pampán estado Trujillo- Venezuela.
A Usability Comparison of SMS and IVR as Digital Banking Channels (2012)

In this paper, the authors compare the usability of SMS mobile banking and automated IVR telephone banking. Participants (N = 116) used SMS banking and IVR banking to find their account balance in a repeated-measures experiment. IVR banking scored higher for usability metrics: effectiveness, attitude, and quality. There was no clear difference in rank order of preference between the two channels. Participants gave positive comments regarding speed and efficiency with SMS banking, but had serious doubts over the security of the SMS channel, impacting consumer trust in SMS banking. The authors argue that usability problems and security concerns are a major factor in the low adoption of SMS mobile banking. Older users were less positive in general to SMS banking compared with the more established IVR banking. Older users had lower first time completion rates for SMS banking and gave IVR banking higher attitude and quality scores.
Resistance thermometer spear for field measurement (1959)

The instrument described measures temperatures in the range -30° to +70° F with an accuracy of ±0.2° F. The sensitive portion consists of a copper wire spiral enclosed in a length of hypodermic tubing; the resistance is measured on a Wheatstone bridge. The instrument is cheap, reliable, robust, and self-contained.
Reversal Learning Deficits Associated with Increased Frontal Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a Prenatal Cocaine Exposure Mouse Model (2016)

Prenatal cocaine exposure remains a major public health concern because of its adverse impact on cognitive function in children and adults. We report that prenatal cocaine exposure produces significant deficits in reversal learning, a key component of cognitive flexibility, in a mouse model. We used an olfactory reversal learning paradigm and found that the prenatally cocaine-exposed mice showed a marked failure to learn the reversed paradigm. Because brain-derived neurotrophic factor (BDNF) is a key regulator of cognitive functions, and because prenatal cocaine exposure increases the expression of BDNF and the phosphorylated form of its receptor, tyrosine kinase B (TrkB), we examined whether BDNF-TrkB signaling is involved in mediating the reversal learning deficit in prenatally cocaine-exposed mice. Systemic administration of a selective TrkB receptor antagonist restored normal reversal learning in prenatally cocaine-exposed mice, suggesting that increased BDNF-TrkB signaling may be an underlying mechanism of reversal learning deficits. Our findings provide novel mechanistic insights into the reversal learning phenomenon and may have significant translational implications because impaired cognitive flexibility is a key symptom in psychiatric conditions of developmental onset.