gebhart/patrepeval huggingface dataset:
Characterization of Genes Involved in Modulation of Conjugal Transfer of the<i>Bacteroides</i>Conjugative Transposon CTnDOT (2002)

In previous studies we identified an 18-kb region of the Bacteroides conjugative transposon CTnDOT that was sufficient for mobilization of coresident plasmids and unlinked integrated elements, as well as self-transfer from Bacteroides to Escherichia coli. When this 18-kb region was cloned on a plasmid (pLYL72), the plasmid transferred itself constitutively in the absence of a coresident conjugative transposon. However, when this plasmid was present in a Bacteroides strain containing a coresident conjugative transposon, conjugal transfer was repressed in the absence of tetracycline and enhanced in the presence of tetracycline. These results suggested that a negative and a positive regulator of conjugal transfer were encoded outside the transfer region of the CTnDOT element. In this work, a minimal and inducible transfer system was constructed and used in transfer and Western blot analyses to identify the differentially regulated genes from CTnDOT responsible for the enhancement and repression of pLYL72 conjugal transfer. Both of these regulatory functions have been localized to a region of the CTnDOT element that is essential for CTn excision. In the presence of tetracycline, the regulatory protein RteC activates the expression of a putative topoisomerase gene, exc, which in turn results in an increase in transfer protein expression and a concomitant 100- to 1,000-fold increase in the frequency of pLYL72 transfer. Our results also suggest that since exc alone cannot result in enhancement of transfer, other factors encoded upstream of exc are also required. Conversely, in the absence of tetracycline, a gene located near the 3' end of exc is responsible for the repression of transfer protein expression and also results in a 100- to 1,000-fold decrease in the frequency of pLYL72 transfer.
R.E.N.A.L. Nephrometry Score Accurately Predicts Complications Following Laparoscopic Renal Cryoablation (2012)

In a multi-institutional cohort of patients undergoing laparoscopic cryoablation, the R.E.N.A.L. nephrometry score is independently associated with the occurrence of complications. Therefore, nephrometry can be used to successfully stratify patients in terms of anticipated risk of complications which, in turn, may help with surgical decision making.
Nonlinear predictive control of an industrial slurry reactor (2008)

A nonlinear model predictive control (NMPC) is applied to a slurry polymerization stirred tank reactor for the production of high-density polyethylene. Its performance is examined to reach the required mean molecular weight and comonomer composition, together with the temperature setpoint. A complete phenomenological model including the microscale, the mesoscale and the macroscale levels was developed to represent the plant. The control algorithm comprises a neural dynamic model that uses a neural network structure with a feedforward topology. The algorithm implementation considers the optimization problem, the manipulated and controlled variables adopted and presents results for the regulatory and servo problems, including the possibility of dead time and multi-rate sampling in the controlled variables. The simulation results show the high performance of the NMPC algorithm based in a model for one-step ahead prediction only, and, at the same time, attests the strong difficulty to control polymer properties with dead time in their measurements.
Fluorescent labeling of Taqman oligonucleotide probes via Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) click chemistry (2017)

We describe an approach to the synthesis of TaqMan oligonucleotide probes that is based on Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) click chemistry when oligonucleotides containing an internal alkynyl group at the pyrimidine position are labeled post-synthetically with a f luorescent azide. TaqMan probes were constructed with f luorescein in different internal positions and a BHQ1 quencher on the 3′-end. Our previously designed alkynylated deoxyuridine or deoxycytidine phosphoramidites have been employed for the synthesis of alkynyl oligonucleotides. It was demonstrated that the synthesized TaqMan probes can detect accumulation of PCR product in real-time. The closer to the label the 3′-terminal quencher, the higher the quenching efficiency, but the efficiency of probe hybridization to DNA template is reduced in this case.
Ring‐opening polymerization of ε‐caprolactone and <scp>L</scp>‐lactide from silica nanoparticles surface (2004)

Abstract Coating of silica nanoparticles by biocompatible and biodegradable polymers of ε‐caprolactone and L ‐lactide was performed in situ by ring‐opening polymerization of the cyclic monomers with aluminum, yttrium, and tin alkoxides as catalysts. Hydroxyl groups were introduced on the silica surface by grafting of a prehydrolyzed 3‐glycidoxypropyl trimethoxysilane to initiate a catalytic polymerization in the presence of metal alkoxides. In this manner, free polymer chains were formed to grafted ones, and the graft density was controlled by the nature of the metal and the alcohol‐to‐metal ratio. The grafting reaction was extensively characterized by spectroscopic techniques and quantified. Nanocomposites containing up to 96% of polymer were obtained by this technique. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 1976–1984, 2004
A Six-Step Synthesis of (.+-.)-Camptothecin (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Six-Step Synthesis of (.+-.)-CamptothecinDaniel L. Comins, Hao Hong, Jayanta K. Saha, and Gao JianhuaCite this: J. Org. Chem. 1994, 59, 18, 5120–5121Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jo00097a004https://doi.org/10.1021/jo00097a004research-articleACS PublicationsRequest reuse permissionsArticle Views1242Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
THE INFLUENCE OF AXLE LOAD, TYRE INFLATION PRESSURE AND USE OF SINGLE WHEEL OR TWINS ON ROAD WEAR (1990)

The Note includes the result of literature studies regarding the influence of traffic loads on pavement deterioration. The traffic load is divided into different elements: axle load, contact pressure and the use of single wheels or twins. The deterioration of pavements is evaluated on stresses and strains as a measure for the road wear and on the development of rut depth. Based on BISAR - calculations for a 28 cm thick asphalt pavement, wear can be foreseen in the upper layers of asphalt in the periphery of the contact areas as well as in the bottom of the asphalt layers. This wear is much bigger under a single wheel than under twins loaded to the same axle load. A revision of the load parameters used in Denmark for pavement design and strengthening, will be necessary. The contact pressure between tyre and road has to be increased as a consequence of the raise of the maximum legal air pressure in the tyres from 7 to 9 bars in 1978. The design wheel load has to be increased as a consequence of the maximum legal load on the driving axle in 1992 which will go up from 10 t to 11,5 t. At the time minor corrections will be made.
Enhanced Oxygen Permeation through a Porous Glass Membrane Containing Phthalocyanato– and Porphyrinato–Cobalt Complexes as an Oxygen Carrier (2006)

Abstract The pore surface of a porous glass membrane was modified with phthalocyanato- and tetraphenylporphyrinato-1-(benzylimidazole)cobalt(II) complexes, which specifically and reversibly binds molecular oxygen from air. The lower oxygen-binding affinity enhanced surface oxygen diffusion which improved permeability (3.0 × 10−11 kmol m s−1 m−2 kPa−1) and (oxygen/nitrogen) permselectivity (10).
Lownet: Privacy Preserved Ultra-Low Resolution Posture Image Classification (2020)

Indoor posture recognition is vital for monitoring/detecting exercises, activities of daily living, accidental falls, unusual behavior, etc. However, high-resolution image based systems have a high accuracy, they are considered as intrusive and most of the current state-of-the-art image classifiers (VGG, ImageNet, ResNext) are not applicable for ultra-low resolution (<; 32 pixels in extent) image classification due to their downsizing feature extraction architecture. Thus, we propose a shallow LowNet model for classifying privacy preserved 16x16 posture images with its feature preserving architecture, variable ReLU slopes, and a custom loss function. LowNet outperformed, with an Accuracy of 98.94% and F1-score of 79.86%, the existing models (LeNet, ResNet1, ResNet-2) which can run on our Ultra lowresolution Thermal Posture Image (UTPI38) dataset (offered here) with 38 classes (4374 samples) collected from 23 volunteers. More experimental results are discussed on the custom loss, and variable ReLU slopes which gave 8.2% performance increase. Thus, we conclude that LowNet is useful in a multiclass ultra-low-resolution thermal posture image classification task.
Resolution enhancement in integral microscopy by physical interpolation (2015)

Integral-imaging technology has demonstrated its capability for computing depth images from the microimages recorded after a single shot. This capability has been shown in macroscopic imaging and also in microscopy. Despite the possibility of refocusing different planes from one snap-shot is crucial for the study of some biological processes, the main drawback in integral imaging is the substantial reduction of the spatial resolution. In this contribution we report a technique, which permits to increase the two-dimensional spatial resolution of the computed depth images in integral microscopy by a factor of √2. This is made by a double-shot approach, carried out by means of a rotating glass plate, which shifts the microimages in the sensor plane. We experimentally validate the resolution enhancement as well as we show the benefit of applying the technique to biological specimens.
Production de rythmes dans la schizophrénie : un déficit de l’alternance de temps (2010)

<titre>Résumé</titre> Le temps est central à tout comportement, permettant notamment de produire une séquence d’actions rythmées. Le but de notre étude est de préciser comment la schizophrénie, pathologie dans laquelle le déficit attentionnel est fréquent, affecte ce contrôle temporel pour l’action. Vingt sujets ont réalisé une tâche de perception et de production de rythmes, une tâche de production de tempo spontané ainsi que deux épreuves neuropsychologiques (mémoire, attention). Les résultats suggèrent un rythme spontané et une perception d’anisochronie préservés chez les patients schizophrènes. Cependant, la production de rythmes est caractérisée chez les patients par une difficulté à réaliser les essais nécessitant l’alternance d’intervalles de temps (variabilité, erreur absolue). L’analyse par corrélations avec les tests cliniques permet de proposer l’hypothèse selon laquelle le déficit d’alternance de temps est lié dans la schizophrénie à une incapacité à disposer des ressources attentionnelles nécessaires pour cadencer les séquences motrices. Plus précisément, ce déficit attentionnel pourrait être lié à un déficit de groupement top-down des intervalles ou à un défaut de flexibilité attentionnelle entre les différents intervalles.
The Clinical Chemist: Masahide Sasaki, MD, PhD (August 27, 1933–September 23, 2005) (2006)

In the 1980s, long before clinical laboratories in the United States were faced with the challenges of consolidation, Masahide Sasaki, MD, PhD, and his associates were inventing what was to become the greatest revolution in clinical laboratory technology since the autoanalyzer. Masahide Sasaki is credited with being the father of modern clinical laboratory automation, a technology that has been installed in laboratories throughout the world.

Sadly, Masahide Sasaki passed away on September 23, 2005, after a valiant fight against cancer. He is survived by his devoted wife Toyoko and his children Mika, Kyoko, and Masanori.

Masahide was born in 1933 in Yamaguchi Prefecture, Japan. He graduated from Yamaguchi Medical School in 1961. During 1965, he served as an internist for the Hiroshima Atomic …
ChemInform Abstract: Enzymatic/Chemical Synthesis and Biological Evaluation of Seven‐ Membered Iminocyclitols. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lithiation Directed by Amino Alkoxides. Application to the Synthesis of New Disubstituted Dihydrodipyridopyrazines (2006)

The synthesis of new 4,6-disubstituted dihydrodipyridopyrazines starting from corresponding carboxaldehydes via lithiation directed by alpha-amino alkoxides is described. The N,N,N'-trimethylethylenediamine was used as amine component for in situ formation of the alpha-amino alkoxides. After optimization, this reaction allowed easy access to new interesting starting materials for further applications by palladium-catalyzed reactions.
Observation of Theoretical Power Saturation by the KHI Free Electron Laser Device (2002)

The saturation of free electron laser (FEL) output power by the KHI-FEL device was achieved on 3rd, October 2000 at the wavelength of 9.3 µm. The FEL device has operated thereafter successfully in the wavelength region between 4.0 and 16.0 µm. The macropulse average FEL power of 37.5 kW, which is the theoretical saturation level, has been obtained at the wavelength of 7.9 µm. The net FEL gain was estimated to be 16%.
Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families. (1998)

We examined linkage between markers at and near the IL4 gene and atopic dermatitis (AD) in 88 Japanese nuclear families. Affected sib pair analysis suggested linkage between the IL4 gene and AD (SPLINK lod=2.28). Transmission disequilibrium testing showed a significantly preferential transmission to AD offspring of the T allele of the -590C/T polymorphism of the IL4 gene (p=0.001). A case-control comparison suggested a genotypic association of the TT genotype with AD (odds ratio=1.88, p=0.01). Since the T allele was reported to be associated with increased IL4 gene promoter activity compared with the C allele, our data indicate that genetic differences in transcriptional activity of the IL4 gene influence AD predisposition, particularly in Japanese, because of a high frequency of the T allele.
Stereoselective Simmons–Smith Cyclopropanation of Chiral Enamides (2007)

Einen effizienten und praktikablen Zugang zu chiralen Aminocyclopropanen bietet die Titelreaktion (siehe Beispiel). Die Cyclopropanierung gelingt mit E- wie mit Z-Enamiden hoch diastereoselektiv (d.r. bis >95:5). Die Synthese biologisch wichtiger Aminocyclopropane illustriert das Potenzial chiraler Enamide als nützliche Bausteine für die stereoselektive organische Synthese. Bn=Benzyl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z700681_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effet des fortes pressions sur l'efficacite insecticide des atmospheres modifiees par CO2 contre Sitophilus granarius (L.) et S. oryzae (L.) (Coleoptera : Curculionidae) (1990)

National audience
Twitter reciprocal reply networks exhibit assortativity with respect to happiness (2011)

The advent of social media has provided an extraordinary, if imperfect, 'big data' window into the form and evolution of social networks. Based on nearly 40 million message pairs posted to Twitter between September 2008 and February 2009, we construct and examine the revealed social network structure and dynamics over the time scales of days, weeks, and months. At the level of user behavior, we employ our recently developed hedonometric analysis methods to investigate patterns of sentiment expression. We find users' average happiness scores to be positively and significantly correlated with those of users one, two, and three links away. We strengthen our analysis by proposing and using a null model to test the effect of network topology on the assortativity of happiness. We also find evidence that more well connected users write happier status updates, with a transition occurring around Dunbar's number. More generally, our work provides evidence of a social sub-network structure within Twitter and raises several methodological points of interest with regard to social network reconstructions.
Influence of Plastic Deformation on the Magnetic Properties of Fe-Al Alloys (2005)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation D. Martín Rodríguez, F. Plazaola, J. S. Garitaonandia, J. A. Jiménez; Influence of Plastic Deformation on the Magnetic Properties of Fe‐Al Alloys. AIP Conf. Proc. 26 April 2005; 765 (1): 190–195. https://doi.org/10.1063/1.1923653 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Evaluation of catalyst preparation parameters using a single turnover (STO) approach (1986)

Psychiatric disorders frequently compound the disability and complicate the management of neurologic conditions. These disorders result in increased morbidity for the person afflicted, stress for the caregiver, and financial burden. This study reviews the randomized double-blind placebo-controlled pharmacologic treatment trials of psychosis, depression, anxiety, and agitation in neurologic conditions from 1966 to 1998. Ten studies involving psychosis, 13 involving depression, and 20 involving anxiety-agitation meeting the committee's criteria were identified. Relatively few randomized double-blind placebo-controlled pharmacologic treatment trials of psychiatric disorders complicating neurologic disease have been conducted. These trials do not strongly support one specific pharmacologic approach to treatment. Further study of newer psychotropic agents, augmentation strategies, and novel use of other agents may help improve the treatment of psychiatric disorders observed in patients with neurologic disease.
Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity (2012)

BACKGROUND.: Electrochemotherapy provides good local tumor control but requires adjuvant treatment for increased local response and action on distant metastasis. In relation to this, intramuscular interleukin-12 (IL-12) gene electro-transfer, which provides systemic shedding of IL-12, was combined with local electrochemotherapy with cisplatin. Furthermore, the dependence on tumor immunogenicity and immunocompetence of the host on combined treatment response was evaluated. MATERIALS AND METHODS.: Sensitivity of SA-1 sarcoma and TS/A carcinoma cells to electrochemotherapy with cisplatin was tested in vitro. In vivo, intratumoral electrochemotherapy with cisplatin (day 1) was combined with a single (day 0) or multiple (days 0, 2, 4) intramuscular murine IL-12 (mIL-12) gene electrotransfer. The antitumor effectiveness of combined treatment was evaluated on immunogenic murine SA-1 sarcoma in A/J mice and moderately immunogenic murine TS/A carcinoma, in immunocompetent BALB/c and immunodeficient SCID mice. RESULTS.: Electrochemotherapy in vitro resulted in a similar IC(50) values for both sarcoma and carcinoma cell lines. However, in vivo electrochemotherapy was more effective in the treatment of sarcoma, the more immunogenic of the tumors, resulting in a higher log cell kill, longer specific tumor growth delay, and also 17% tumor cures compared to carcinoma where no tumor cures were observed. Adjuvant intramuscular mIL-12 gene electrotransfer increased the log cell kill in both tumor models, potentiating the specific tumor growth delay by a factor of 1.8-2 and increasing tumor cure rate by approximately 20%. In sarcoma tumors, the potentiation of the response by intramuscular mIL-12 gene electrotransfer was dose-dependent and also resulted in a faster onset of tumor cures. Comparison of the carcinoma response to the combined treatment modality in immunocompetent and immunodeficient mice demonstrated that the immune system is needed both for increased cell kill and for attaining tumor cures. CONCLUSIONS.: Based on the comparison of the antitumor effectiveness of electrochemotherapy to intratumoral cisplatin administration, we can conclude that the fraction of cells killed and the tumor cure rate are higher in immunogenic sarcoma tumor compared to moderately immunogenic carcinoma tumor. The tumor cell kill and cure rate depend on the immune response elicited by the destroyed tumor cells, which might depend on the tumor immunogenicity. The effect of adjuvant intramuscular mIL-12 gene electrotransfer is dependent on the amount of IL-12 in the system and the immune competence of the host, as demonstrated by the dose-dependent increase in the cure rate of SA-1 tumors after multiple intramuscular mIL-12 gene electrotransfer and in the differential cure rate of TS/A tumors growing in immunocompetent and immunodeficient mice.
Hollow Six‐Stranded Helical Columns of a Helicene (2009)

Gleich und gleich gesellt sich gern: Ein Helicenbischinon (siehe Formel) bildet in enantiomerenreiner wie racemischer Form hexagonal-columnare Phasen, in denen das Säuleninnere aus hohlen 132-Helices mit Wiederholungseinheiten aus sechs Molekülen besteht (siehe Längs- und Seitenansicht). Die enantiomerenreine Verbindung liegt in einer hexagonalen Struktur vor, im Racemat trennen sich die Enantiomere in rechts- und linkshelicale Säulen, die verzahnt und gegeneinander verschoben sind, um eine optimale Packung zu erzielen.
The Human Tumor-Egg Host System II. Discovery and Properties of a New Antitumor Agent, Hadacidin. (1962)

A new crystalline antitumor agent, hadacidin, has been discovered in fermentation broths of Penicillium frequentans Westling. The human tumor-embryonated egg system was used to guide fermentation and isolation studies. Against HAD #1 the tumor ID50 of hadacidin is about 3 mg per egg. Hadacidin is active also against HEP #3 and A-42 in the embryonated egg. On a weight basis, hadacidin has about the same range of activity as azaserine and 6-mercaptopurine but has only one per cent the activity of the alkylating agent, triethylene melamine.