gebhart/patrepeval huggingface dataset:
Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease (2010)

A transcription factors analysis of 1,372-probe signature reveals significant associations with the EGR/KROX family of proteins, MAZ, and E2F1. The gene homologous of EGR1, zif268, Egr-1 or Zenk, together with other members of the EGR family, are consolidating a key role in the neuronal plasticity in the brain. These results indicate a degree of commonality between putative genes involved in AD and prion-induced neurodegenerative processes that warrants further investigation.
CONSTRUCTIVE WAVELET COEFFICIENTS MEASURING SMOOTHNESS THROUGH BOX SPLINES (1996)

ABSTRACT. We provide a constructive wavelet decomposition of L p (1 p 1) into box splines. To calculate wavelet coefficients, we apply the local polynomial L2-approximation and then quasi-interpolation techniques. Furthermore, we characterize the Besov space, Bq.Lq / (q D.=dC1=p/−1), by the constructive wavelet coefficients with an explicit form. DeVore et al. have studied this characterization with a different proof; however, they have used a nonconstructive local approximation rather than the local L2-approximation when 0 &lt; q 1. Our explicit formula calculating wavelet coefficients can be directly employed for numerical implementations. 1.
An out‐of‐frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production (2000)

We have isolated transmitochondrial cybrids containing a mitochondrial DNA cytochrome b 4–base pair deletion previously identified in a patient with parkinsonism. This presentation is in contrast to that of most patients with cytochrome b mutations, who present with exercise intolerance. Clones containing different levels of the cytochrome b 4–base pair deletion showed that high levels of the mutation were associated with a respiratory deficiency and a specific complex III defect. Newly synthesized full-length cytochrome b was undetectable by metabolic labeling of mutant cells, and these cells were unable to grow in media that restricts proliferation of cells with defective oxidative phosphorylation. Steady state levels of some subunits previously found to be in close association with cytochrome b by crystallography and biochemical analysis (ie, Rieske [2Fe-2S] protein and subunit VI) were drastically reduced in clones containing high levels of the mutation, whereas the reduction in the core-1 subunit was milder. The absence of cytochrome b and complex III activity was also associated with increased hydrogen peroxide production. These findings, together with the variable tissue distribution of pathogenic mitochondrial DNA molecules, provide clues to the heterogeneous phenotypes associated with mitochondrial DNA mutations and establish a link between different forms of parkinsonism and oxidative phosphorylation defects. Ann Neurol 2000;48:774–781
Responses in rabbits to the red cell alloantigen HgA. (1974)

Successive injections of Hg(A)-positive red cells were given at intervals of 2–3 months to Hg(A)-negative rabbits. In forty-four out of fifty-one animals, red cell survival became progressively shorter and, in the majority of instances, anti-Hg(A) was found in the serum. Characteristically, the first survival curve was initially normal but showed `collapse' after a mean interval of 17 days; following subsequent injections, cells were cleared at an accelerated rate. In the remaining seven Hg(A)-negative rabbits the survival of Hg(A)-positive red cells was either repeatedly normal or was subnormal after the first one or two injections and became almost normal following further injections. In four out of six of these animals, following additional injections of Hg(A)-positive cells given i.m. with FCA, anti-Hg(A) became detectable in the serum. Thus, some animals which appeared to be non-responders to Hg(A) as judged by normal survival of Hg(A)-positive red cells after i.v. injection alone showed some response when antigen was also given i.m. with adjuvant.
A context-aware cost of interruption model for mobile devices (2011)

Unwanted and untimely interruptions have been a major cause in the loss of productivity in recent years as they are mostly detrimental to the immediate task at hand. Multiple approaches have been proposed to address the problem of interruption by calculating cost of interruption. The cost of interruption (COI) gives as a measure the probabilistic value of harmfulness of an inopportune interruption. Bayesian Inference stands atop among the models that have been applied to calculate this COI. However Bayesian inference based models suffer from not being able to model context accurately in situations where priori, conditional probabilities and uncertainties exist while utilizing context information. Hence, this paper introduces Dempster-Shafer Theory of Evidence to model COI. Along the way, we also identify different contexts necessary for interruption management applications. We also show an illustrative example of a mobile interruption management application where the Dempster-Shafer theory is used to get a better measurement of whether to interrupt or not.
Generation of High-Quality Tunable One-Dimensional Airy Beams Using the Aberrations of a Single Lens (2012)

We designed a highly tunable optical system for generating very good quality 1-D optical Airy beams. The system is composed of only a few passive elements-a microscope objective, a lens, and an aperture stop-so it is easy to align and has no power limits. An analytical formula for the characteristic coefficient of Airy beams was obtained as a function of two control parameters (object position and tilt angle of the lens), showing that it is possible to obtain a wide range of values, from a few micrometers to over 200 μm using the same elements, simply by varying the geometric parameters of this optical system.
Implementation of a customizable fault tolerance framework (2002)

While there has been significant advances in fault tolerance research, the effort has focused on the design of individual fault-tolerant systems or methodologies. Recently, some research has been initiated to develop fault tolerance paradigms that can be used to provide a spectrum of fault tolerance levels. In this paper, we present the design of a fault tolerance framework that can be used to support a wide spectrum of applications with various fault tolerance requirements, various criticality levels, and various system models. The framework is designed to be parameterizable so that the user can configure it to obtain the desired features. Also, the framework is designed to be an off-the-shelf component such that application programs can be integrated within it easily to obtain the fault-tolerant version of the application system. A specialized N-modular redundancy (SNMR) scheme has been developed to serve as the primary approach for achieving efficient and cost-effective fault tolerance for the framework. In most cases, the SNMR scheme yields better performance and lower cost in providing fault tolerance as compared with conventional NMR schemes. It also enhances the scalability and customizability of the general replication method. This paper discusses the major concept of the SNMR framework and the main issues in the design and implementation of the framework, including an object-oriented overall system design and the interface protocol class hierarchy. The interface protocol class hierarchy provides a nice paradigm for the implementation of customizable, highly reusable, and easily extensible SNMR framework.
Sensing with One or with Four? A Comparison of Two IEEE 802.15.x Protocols for Use in Sensor Networks (2007)

In this paper we compare the pertinent features of the two emerging technologies for wireless sensor networks: IEEE Standards 802.15.1 and 802.15.4. We review the main features of the MAC protocols defined by those standards, describe their operation, and compare them in terms of characteristics such as performance (access and end-to-end packet delays), bandwidth utilization, and scalability for the deployment of large networks. Our findings indicate that there is no clear winner in all categories; the best protocol (and the underlying technology) to use, are heavily dependent upon the requirements for a particular sensing application. While the main focus of our analysis is the MAC layer, certain important parameters of the Physical (PHY) layer are considered as well, together with some other networking aspects. The results of this analysis should be of interest to the designer and operators of wireless sensor networks.
Distributed Compressive CSIT Estimation and Feedback for FDD Multi-User Massive MIMO Systems (2014)

To fully utilize the spatial multiplexing gains or array gains of massive MIMO, the channel state information must be obtained at the transmitter side (CSIT). However, conventional CSIT estimation approaches are not suitable for FDD massive MIMO systems because of the overwhelming training and feedback overhead. In this paper, we consider multi-user massive MIMO systems and deploy the compressive sensing (CS) technique to reduce the training as well as the feedback overhead in the CSIT estimation. The multi-user massive MIMO systems exhibits a hidden joint sparsity structure in the user channel matrices due to the shared local scatterers in the physical propagation environment. As such, instead of naively applying the conventional CS to the CSIT estimation, we propose a distributed compressive CSIT estimation scheme so that the compressed measurements are observed at the users locally, while the CSIT recovery is performed at the base station jointly. A joint orthogonal matching pursuit recovery algorithm is proposed to perform the CSIT recovery, with the capability of exploiting the hidden joint sparsity in the user channel matrices. We analyze the obtained CSIT quality in terms of the normalized mean absolute error, and through the closed-form expressions, we obtain simple insights into how the joint channel sparsity can be exploited to improve the CSIT recovery performance.
Studies in Organic Peroxides. XXX. Organic Peroxides Derived from 2,5-Hexanedione and Hydrogen Peroxide<sup>1a</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in Organic Peroxides. XXX. Organic Peroxides Derived from 2,5-Hexanedione and Hydrogen Peroxide1aNicholas A. Milas and Aleksandar GolubovicCite this: J. Org. Chem. 1962, 27, 12, 4319–4323Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/jo01059a044https://doi.org/10.1021/jo01059a044research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
2. ‐‐ DEVELOPMENT OF DIRECTION SENSE AND THREE SYNDROMES OF IMPAIRMENT∗ (1965)

∗ The authors are supported in research by Research Grant HD‐00325 and Research Career Development Award HD‐K3‐18,635, The National Institute of Child Health and Human Development, United States Public Health Service.
A CMOS bandgap voltage reference with absolute value and temperature drift trims (2005)

We present a curvature-corrected CMOS bandgap voltage reference with in-package trim of the absolute value and first-order temperature drift during the final test. The trim settings are stored using a poly fuse ROM. The output buffer has a single-stage topology with voltage and current gain boosts, providing 20 /spl mu/V/mA load regulation and frequency stability with any load. The total error of the voltage reference, implemented in the TSMC 0.6 /spl mu/m process, does not exceed 200 ppm in the full temperature (-40/spl deg/C to 125/spl deg/C), supply (1.8 V to 5.5 V) and load (/spl plusmn/10 mA) range.
Complexity of vehicle routing and scheduling problems (1981)

Abstract The complexity of a class of vehicle routing and scheduling problems is investigated. We review known NP‐hardness results and compile the results on the worst‐case performance of approximation algorithms. Some directions for future research are suggested. The presentation is based on two discussion sessions during the Workshop to Investigate Future Directions in Routing and Scheduling of Vehicles and Crews, held at the University of Maryland at College Park, June 4–6, 1979.
N-Acetylcysteine and mucociliary activity in mammalian airways. (1978)

The effect of N-acetylcysteine on mucus trasnport velocity (MV), ciliary beat frequency (CBF), mucus production (MP), mucus lysis and on the micro-morphology of the secretory cells was studied in mammalian airways. The results showed that: 1. MV increased in healthy rats and rabbits, as well as in bronchitic rats, after concentrations as low as 10(-14) g/ml. Depression of MV occurred first at 10(-6) and 10(-5) g/ml in healthy and bronchitic animals, respectively. 2. CBF was stimulated at concentrations between 10(-12) and 10(-10) g/ml and decreased at concentrations above 10(-8) g/ml. 3. MP increased by approximately 100% over control values. 4. Lysis of stagnant mucus was evident first at a concentration of 10(-11) g/ml after 15 min incubation. 5. TEM confirmed the increased activity of the mucus secreting cells and showed that no pathological changes occurred within the cell following incubation at 10(-7) g/ml for up to 150 min. The importance of these findings on the overall mucociliary function is discussed.
Multi-tier service restoration through network reconfiguration and capacitor control for large-scale radial distribution networks (2000)

A fast and effective service restoration algorithm allowing multi-tier or system-wide switching and capacitor control actions is developed for large-scale, radial distribution networks. The service restoration problem is formulated as a constrained multiple-objective optimization problem. A solution algorithm designed to consider networks with predominately manual switches is developed which utilizes information calculated from three-phase power flow analysis to restore as much priority and total load as possible while requiring a minimal number of control actions and amount of geographic travel distance. Simulation results are presented for a 399 bus distribution network and compared to the service restoration algorithm which avoided multi-tier switching.
An accurate exploration of timing and area trade-offs in arithmetic optimization using carry-save adder cells (2002)

Timing and area of circuits are two of the most important design criteria to be optimized in data path synthesis. Further, carry-save adder (CSA) cell has been proven to be one of the most effective hardware units in optimizing timing and area of the circuits. However, the prior approaches have only been concerned with the optimization of a single operation tree using CSAs, and have not been able to optimize multiple operation trees properly. This paper proposes a practical solution to the problem of an accurate exploration of trade-offs between timing and area in optimizing arithmetic circuit using CSAs. The application of the approach leads to finding a best CSA implementation of circuit in terms of both timing and area.
Solution Grown Crystals of an Acetal Resin (1959)

Single crystals of polyoxymethylene have been grown from dilute solution. They consist of hexagonal lamellae, often thickened by growth from screw dislocations. The chain molecules are normal to the lamellae which are 100 A thick. Thus, it is suggested that the molecules have a folded conformation. In many of the crystals double Bragg reflections were found in the electron diffraction patterns, resulting from rotation of the lamellae during growth. Dark field electron microscope photographs of these crystals exhibit moiré patterns.
Deposition of Large‐Area and Protective Diamond‐like Carbon Coatings on Glass Substrates by Low‐Pressure Dielectric Barrier Discharges (2010)

Large‐area (370mm×500mm) diamondlike carbon (DLC) films were deposited on the glass substrate by low‐pressure dielectric barrier discharges. The deposited DLC films were hard, homogeneous and extremely smooth. The DLC film deposited on the large‐area glass can be potentially used as a scratch resistant and corrosion barrier layer.
Voltammetric Detection of Dopamine in Presence of Ascorbic Acid and Uric Acid at Poly (Xylenol Orange) Film-Coated Graphite Pencil Electrode (2011)

Poly (xylenol orange) film-coated graphite pencil electrode was fabricated for the detection of dopamine in the presence of ascorbic acid and uric acid in phosphate buffer solution of pH 7. The redox peaks obtained at modified electrode shows a good enhancement. The scan rate effect was found to be a diffusion-controlled electrode process. The electrochemical oxidation of dopamine was depended on pH, and the limit of detection was found to be 9.1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mo>×</mml:mo></mml:math>10 −8 M. The simultaneous study gave and excellent result with great potential difference between dopamine and other bioactive organic molecules by using both cyclic voltammetric and differential pulse voltammetric techniques. The present modified graphite electrode was applied to the detection of dopamine in the injection samples, and the recovery obtained was satisfactory.
Pressor effects of the tail-cuff method in awake normotensive and hypertensive rats. (1971)

RUBEN D. BUWAG Eansas City, MO.* Blood pressure standards established previously by using the tail-cuff method in awake rats usually include the cardiovascular effects of heating and restraint. To study the influence of these extraneous factors, arterial pressures were measured in unanesthetized normotensive and hypertensive rats with chronically implanted aortic catheters. When both tail-cuff and aortic pressures were recorded, rats had to be heated and restrained, and average aortic pressures were all high, But when aortic pressures were recorded alone, rats were neither heated nor restrained because the tail-cuff method was not used and consequently all average aortic pressures were low. These data suggest that the tail-cuff method by itself produces significant pressor effects. Rats with a clipped renal artery could invariably be classified as hypertensive when the tail-cuff method was used to measure pressure, but when tail-cuff measurements were omitted, aortic pressures in more than half of them were within normotensive range. However, in rats with spontaneous hypertension, aortic pressures remained consistently elevated even when tail-cuff determinations were not made. I t was recently shown that tail-cuff values approximate true arterial pressures accurately only when normotensive rats are anesthetized, but not when they are awake.3 Because the tail-cuff method is so widely used for defining normotensive and hypertensive states in awake rats, the present studies were done primarily to determine validity of such classifications.
Proteomic Analysis of Steady-State Nuclear Hormone Receptor Coactivator Complexes (2005)

We report our initial efforts in the analysis of endogenous nuclear receptor coactivator complexes as a research bridging strand of the Nuclear Receptor Signaling Atlas (NURSA) (www.NURSA.org). A proteomic approach is used to systematically isolate a variety of coactivator complexes using HeLa cells as a model cell line and to identify the coactivator-associated proteins with mass spectrometry. We have isolated and identified seven coactivator complexes including the p160 steroid receptor coactivator family, cAMP response element binding protein-binding protein, p300, coactivator of activating protein-1 and estrogen receptors, and E6 papillomavirus-associated protein. The newly identified coactivator-associated proteins provide unbiased clues and links for understanding of the endogenous hormone receptor coregulator network and its regulation. We hope that the electronic availability of these data to the general scientific community will facilitate generation and testing of new hypotheses to further our understanding of nuclear receptor signaling and coactivator functions.
Alkoxysilanes. IV. Preparation of Alkoxysiloxy Derivatives of Titanium (1970)

Abstract Alkoxysiloxy derivatives of titanium and polymeric substances with Ti–O–Si bonds were prepared. The reaction of titanium tetra-isopropoxide or bis (acetylacetonato)di-isopropoxytitanium with tri-t-butoxysilanol led to the formation of the derivatives of [(ButO)3SiO]nTi(OPri)4−n (n=2 and 3) and those of [(ButO)3SiO]2Ti(AcAc)2 respectively. In both of these series, the absorption peak of the Ti–O–Si bond in the IR spectrum shifted toward a lower wave number from the compounds of n=2 to those of n=3. The reaction of titanium tetra-isopropoxide with di-t-butoxysilanediol, as expected, gave a polymeric substance. In the reaction with bis(tri-t-butoxysiloxy)-silanediol, however, an unexpected cyclic compound consisting of the Ti–O–Si bond was obtained; its presence was confirmed by a study of the IR and NMR spectra, by elemental analysis, and by molecular-weight determination. In order to obtain a linear polymer, the reaction of the titanium acetylacetonato chelate with the silanediols was carried out to give a reddish-brown, highly viscous liquid or solid. These polymeric substances were soluble in common organic solvents and have an appreciable hydrolytic stability, but only a moderate thermal stability.
How to Create Videos for Extension Education: An Innovative Five-Step Procedure (2018)

Although the benefits of using video as a learning tool in Extension programs are well known, less is understood about effective methods for creating videos. We present a five-step procedure for developing educational videos that focus on evidence-based practices, and we provide practical examples from our use of the five steps in creating a video series for an Extension program. Through the effective development of videos, Extension professionals can organize and present information in a meaningful way.
The Euclid algorithm and the fast computation of cross-covariance and autocovariance sequences (1989)

A simple linear procedure is given to compute the cross-covariance sequence associated with the outputs of two rational digital transfer functions driven by the same white noise sequence. Such a computation often appears in the study of digital filters, in Wiener filtering, in noise variance estimation, in the study of low-order approximations, and in the study of multichannel systems. A fast algorithm based on the Euclid algorithm is introduced to solve the linear system of equations involved in the computation, and a detailed analysis of the matrix is given. The special case of the autocovariance computation is reviewed, and the same study is performed. Alternate polynomial presentations are given and are shown to involve the same matrices and similar fast algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>