gebhart/patrepeval huggingface dataset:
The effects of dexamethasone treatment on immunoreactive and bioactive insulin-like growth factors (IGFs) and IGF-binding proteins in normal male volunteers (1993)

Glucocorticoids inhibit somatic growth in man and laboratory animals, and have long been regarded as suppressors of both stimulated GH secretion and insulin-like growth factor (IGF) activity. Recent evidence suggests, however, that glucocorticoids can be potent GH secretagogues in their own right with concomitant increases in circulating IGF-I levels. IGFs circulate tightly bound to a group of high-affinity binding proteins (IGFBPs) which modulate their actions. In order to investigate the effects of glucocorticoids on serum levels of IGFs and IGFBPs, normal male volunteers were sampled over 24-h periods before and directly after treatment with dexamethasone (2 mg twice daily) for 96 h. Following dexamethasone administration, all volunteers showed a marked increase in mean +/- S.E.M. IGF-I levels over the 24-h sampling period (292.2 +/- 31.8 before dexamethasone, 425.9 +/- 37 micrograms/l after dexamethasone, P < 0.005); there was no change in mean IGF-II levels. Integrated mean insulin levels were raised by dexamethasone treatment (50 +/- 4.6 before dexamethasone, 117 +/- 13.4 mU/l after dexamethasone, P = 0.002) and IGFBP-1 was significantly suppressed (42.9 +/- 8.2 before dexamethasone, 28.0 +/- 7.9 micrograms/l after dexamethasone, P < 0.001). IGFBP-2 levels were similarly suppressed after dexamethasone (319.5 +/- 24.5 before dexamethasone, 214.8 +/- 8.5 micrograms/l after dexamethasone, P = 0.002), and there was a significant increase in IGFBP-3 levels from 3.24 +/- 0.25 to 3.67 +/- 0.32 mg/l (P = 0.0153). Mean IGF bioactivity over the sampling period after dexamethasone was reduced by approximately 60% (0.93 +/- 0.39 before dexamethasone, 0.39 +/- 0.05 U/ml after dexamethasone, P < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
Einführung (1994)

Zwei Jahrzehnte nach dem Zusammenbruch des Bretton-Woods-Systems und dem Übergang zu flexiblen Wechselkursen zwischen den USA und den wichtigsten Industrienationen stellt die Erklärung und Prognose des Verhaltens frei schwankender Wechselkurse immer noch ein weithin ungelöstes Problem dar. Bei einer Vielzahl von Untersuchungen hat es sich gezeigt, daß das Wechselkursverhalten sehr stark einem random-walk-Prozeß ähnelt, bei dem die Veränderungen von Periode zu Periode kaum vorhersehbar sind (vgl. z.B. Frenkel und Mussa [1985] bzw. Kapitel 7 der vorliegenden Arbeit). Dies gilt insbesondere für die kurzfristige Zeitreihencharakteristik, falls die Datenbasis auf wöchentlichen, täglichen oder mehreren Beobachtungen innerhalb eines Tages beruht.
Customization of IBM Intu’s Voice by Connecting Text-to-Speech Services and a Voice Conversion Network (2018)

IBM has recently launched Project Intu, which extends the existing web-based cognitive service Watson with the Internet of Things to provide an intelligent personal assistant service.
Novel approaches of wafer level packaging for MEMS devices (2012)

Wafer Level Packaging (WLP) has started to shine and played a prominent role in recent years in both semiconductor and Integrated Circuit (IC) field, especially in now thriving Micro-Electro-Mechanical System (MEMS) applications on account of its distinctive operating mechanism and adaptive design variety. In this study, several crucial WLP technologies are disclosed in detail, including Wafer to Wafer (W2W) bonding, wafer level wire bonding, wafer level compound molding and lapping. Simplified and conceptual process flow of MEMS WLP and development approaches are introduced and explained. Furthermore, relevant experimental results and technology characteristics, including glass frit printing and bonding results & shear strength in W2W bonding technology, wire shift & vertical loop height & ball shear & wire pull in wafer level wire bonding technology, Thickness to Thickness Variation (TTV) & wire sweep & warpage in wafer level compound molding technology, have also been extensively demonstrated. After MEMS WLP packaging process, device performance is then determined by the difference of voltage readout with the implementation of Wafer Level Dynamic Test (WLDT) before and after Highly Accelerated Stress Test (HAST), and the wafer device yield is also presented.
Mycobacterial infections in the transplant patient. (1990)

Mycobacterial infections in the transplant recipient differ considerably from those occurring in the normal host. The incidences of active disease, atypical disease, and extrapulmonary disease, especially dissemination, are all increased. These differences are reflected clinically in an increased mortality (30%) and a high rate (37%) of infection associated with rejection. The clinician must rely on sparse data to draw conclusions regarding prophylaxis and therapy. In general, cyclosporine-related drug interactions must be constantly monitored. Pyrazinamide should replace rifampin whenever cyclosporine is in use. Prompt recognition of the diverse presentations of mycobacterial disease and definitive diagnosis and treatment will improve outcome.
Writing speed and tonal range of dark trace tubes (1955)

The writing speed and tonal range properties of dark trace tubes are analyzed and figures of merit are outlined. Experimental results are presented. Writing speed of a dark trace tube varies linearly with the ratio of beam current to spot size. The information writing rate varies directly with the beam current and inversely with the square of the spot size. The tonal range of dark trace tubes varies directly with the ratio of maximum contrast to spot size.
Blending thermoplastic polyurethanes and poly(ethylene oxide) for composite electrolytes via a mixture design approach (2000)

With the aim of obtaining proper composite electrolytes, a systematic modeling analysis for the percentage increase in weight due to swelling with respect to swollen weight, Sw, and the room temperature conductivity (σ25) of the composite films of polyethylene glycol based thermoplastic polyurethane/polytetramethylene glycol based thermoplastic polyurethane/polyethylene oxide [denoted as TPU(PEG)/TPU(PTMG)/PEO] was performed. Using a mixture design approach, empirical models are fitted and plotted as contour diagrams which facilitate revealing the synergistic/antagonistic effects among the mixed polymers. The contour plot results show that both the maximum Sw (64.9%) and the maximum σ25 (72.2 × 10−5 S cm−1) appear at point X3 (PEO 85%, TPU(PEG) 15%). The results are reasonably explained from the interactions among polymers on the basis of their molecular structures. The thermal analysis of the composite films is performed to demonstrate the speculations about the interactions among the mixed polymers by using differential scanning calorimeter. The crystallization of PEO spherulites at different compositions was examined by using a polarizing microscope. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 680–692, 2000
Anodic Oxidation of aliphatic Acids at Carbon Anodes (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnodic Oxidation of aliphatic Acids at Carbon AnodesW. J. KoehlCite this: J. Am. Chem. Soc. 1964, 86, 21, 4686–4690Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/ja01075a032https://doi.org/10.1021/ja01075a032research-articleACS PublicationsRequest reuse permissionsArticle Views459Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A fast, simple, and reproducible automated synthesis of [<sup>18</sup>F]FPyKYNE‐c(RGDyK) for <i>α</i><sub>v</sub><i>β</i><sub>3</sub> receptor positron emission tomography imaging (2011)

[ 18 F]FPyKYNE‐c(RGDyK) was successfully synthesized by the Cu(I) catalyzed Huisgen 1,3‐dipolar cycloaddition of alkynes to azides using [ 18 F]FPyKYNE as a prosthetic group in an overall radiochemical yield of 12%–18% (decay‐corrected) and >99.5% chemical and radiochemical purities in 125 min including quality control. This simple, fully automated two‐step, two‐reactor approach consists of a quick and convenient purification of the prosthetic group using silica gel cartridges and its subsequent use for the labeling of the azido‐c(RGDyK) peptide via click chemistry.
ADC-Based Backplane Receivers: Motivations, Issues and Future (2016)

The analog-to-digital-converter-based (ADCbased) backplane receivers that consist of a front-end ADC followed by a digital equalizer are gaining more popularity in recent years, as they support more sophisticated equalization required for high data rates, scale better with fabrication technology, and are more immune to PVT variations. Unfortunately, designing an ADC-based receiver that meets tight power and performance budgets of high-speed backplane link systems is non-trivial as both frontend ADC and digital equalizer can be power consuming and complex when running at high speed. This paper reviews the state of art designs for the front-end ADC and digital equalizers to suggest implementation choices that can achieve high speed while maintaining low power consumption and complexity. Design-space exploration using system-level models of the ADC-based receiver allows through analysis on the impact of design parameters, providing useful information in optimizing the power and performance of the receiver at the early stage of design. The system-level simulation results with newer device parameters reveal that, although the power consumption of the ADC-based receiver may not comparable to the receivers with analog equalizers yet, they will become more attractive as the fabrication technology continues to scale as power consumption of digital equalizer scales well with process.
Experimental congenital malformations. (1975)

Traditional approaches to human and experimental teratology are briefly described, with roles of pathologists indicated. Some approaches to experimental teratology which pathologists might use are then described and illustrated. These include identification of subclasses of malformation types, study of the chronologic sequence of maldevelopment, study of embryo death, and examination of tumor-malformation relationships. The malformations used to illustrate these approaches are cleft palate, anencephaly, hydrocephalus, and intestinal atresia. The final section deals with general methodology in experimental teratology; a listing of books dealing with experimental teratology is included.
Application of Natural Bond Orbital Analysis and Natural Resonance Theory to Delocalization and Aromaticity in Five-Membered Heteroaromatic Compounds (1998)

The various measures of delocalization in all of the five-membered nitrogen and oxygen heteroaromatic compounds (azoles and oxoles) were obtained from MO calculations at the HF/6-31G level and the application of natural bond orbital analysis and natural resonance theory. The hydrogen transfer and aromatic energies of these compounds were also calculated. These were compared to the relative ranking of aromaticity reported by Katritzky from a principal component analysis of other measures of aromaticity. It was concluded that the extent of the transfer of electron density from the p(z)() orbital of the heteroatom to the rest of the pi system is the best measure of delocalization and "aromaticity" of these compounds. This indicated that all of the oxoles are less delocalized than any of the azoles because the electronegativity of the oxygen atom prevents the interaction of its lone pair of electrons with the pi system. For this reason the range of delocalization in the oxoles is also much narrower. The degree of delocalization in the pi system is the result of the geometry imposed by the sigma structure, which in turn is defined by the identity and arrangement of the atoms of the ring.
Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes. (1991)

When the leukemia cells in 14 patients with acute promyelocytic leukemia (APL) were induced by all-trans retinoic acid (RA) treatment, the activity of protein kinase C (PKC) increased with the differentiation. In the control cells, the activity of PKC was only 47 +/- 39.3 pmol.mg-1/min, while it was 149.3 +/- 150.1 pmol.mg-1/min after differentiation. There were 90.1 +/- 7.2% promyelocytes in the control group, and 8.9 +/- 5.6% in the induction group. Therefore, we think that there is a close correlation between PKC and the differentiation of promyelocytic leukemia cells.
Chemical Composition of the Essential Oil of <i>Hyptis spicigera</i> Lam. from Burkina Faso (1993)

ABSTRACT Thirty-four compounds have been characterized by GC/MS and relative retention times in three Hyptis spicigera oil samples produced from plant material growing in Burkina Faso. The oils were characterized by a high content in β-caryophyllene (57–66%). α-Pinene (2–5%) and sabinene (4–5%) were the major monoterpenes. Methyl palmitate (1–1.5%) was identified in all samples.
Determination of Gamma-Isomer Content of Benzene Hexachloride (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Gamma-Isomer Content of Benzene HexachlorideS. V. Bowen and M. A. PogorelskinCite this: Anal. Chem. 1948, 20, 4, 346–348Publication Date (Print):April 17, 1948Publication History Published online1 May 2002Published inissue 17 April 1948https://pubs.acs.org/doi/10.1021/ac60016a022https://doi.org/10.1021/ac60016a022research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Treatment of epilepsy in the multiply handicapped (2000)

The medical management of epilepsy in the multi-handicapped patient requires careful evaluation, classification, and pharmacologic treatment. It is estimated that 20-40% of patients with mental retardation and cerebral palsy have epilepsy. This review reports the clinical trial data and personal experience related to the use of newer AEDs in the chronic management of epilepsy syndromes in children and adults, as well as information available on the treatment of seizures in individuals with mental retardation and associated handicaps. Furthermore, clusters of seizures, prolonged seizures and status epilepticus are more commonly seen in the multiply handicapped and mentally retarded population and require special attention. The new antiepileptic drugs felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate, vigabatrin and zonisamide show specific advantage in some multiply handicapped patients, be it for seizure control or medication tolerance. Furthermore, new modalities of treatment for prolonged seizures allow better efficacy both outside of hospital and within hospital facilities. The treatment of epilepsy in multi-handicapped and retarded adults and children has significantly advanced in the past few years, and much of this improvement can be attributed to improved knowledge and monitoring of new antiepileptic drugs. Conventional anticonvulsants remain first line therapy for most clinicians, but newer AEDs must broaden the therapeutic option and do allow improved therapy for some multiply handicapped patients.
An Amphiphilic Lutetium Bisphthalocyanine: Lu[(PEO)<sub>4</sub>Pc][(DodO)<sub>4</sub>Pc] (1999)

The synthesis of an amphiphilic lutetium bisphthalocyanine is described. One phthalocyanine of the sandwich complex bears four hydrophobic chains (C12H25O = DodO), and the other bears four hydrophilic polyether groups (CH3(OCH2CH2)nO = PEO). The molecule has been characterized by 1H NMR and ESI mass spectrometry. The mean value for n, the number of polyethyleneoxy units in the starting PEOH, is 8 with a Gaussian distribution around that value; however, for the most abundant lutetium bisphthalocyanine, 4n = 26. On the spectrum, the peak corresponding to the adduct with two Na+ is higher than the one of the singly charged ion, a result of the affinity of polyethers for alkali ions.
An Ultralightweight Mutual Authentication Protocol for Low Cost RFID Tags (2011)

RFID (Radio Frequency identification) is emerging as an important tool in the field of Automatic Identification Technologies. The universal deployment of RFID devices may expose new security and privacy risks. These risks are the main obstacle for successful deployment of RFID tags. Since, the traditional cryptographic approach is not suitable for the RFID tags due to its limited computation resources and small storage capacity. This paper proposes an effective and efficient ultralightweight mutual authentication protocol, to achieve stronger security and privacy by using only simple bitwise operations (e.g. XOR, modulus addition). The proposed protocol is inspired by the Gossamer protocol of ultralightweight protocol family and by using its existing Rotation and Mixbit function.
Phenobarbital-induced alterations in the sexual differentiation of the female rat: reversal by hydroxyurea and cycloheximide. (1982)

The possible mechanism of action of phenobarbital in prenatal female rats has been studied using different inhibitors of protein/DNA/RNA synthesis. Administration of phenobarbital (40 mg/kg/day) subcutaneously from day 17 to day 20 of pregnancy resulted in a delay of the onset of puberty, disorders of estrous cycle, infertility, and high estrogen levels in the female offspring. Cycloheximide (60 microg/kg/day)--a protein synthesis inhibitor and hydroxyurea (160 mg/kg/day)--a DNA synthesis inhibitor when combined with phenobarbital, significantly reduced the incidence of reproductive dysfunctions listed above. Alpha-amanitin (15 microg/kg/day), an inhibitor of m-RNA synthesis, produced reproductive disorders in the female offspring when administered alone to pregnant rats and also failed to reverse the PB-induced reproductive alterations. Cycloheximide and hydroxyurea produced no effect upon reproductive function when administered alone. Cycloheximide administration resulted in low body weight at birth and delayed eye opening. These results suggest that prenatal administration of phenobarbital produces its effect via new protein synthesis and that cycloheximide and hydroxyurea protect the offspring from phenobarbital-induced toxic effects by inhibiting its biochemical action.
3D printed stainless steel microelectrode arrays (2017)

This paper reports the design and fabrication of highdensity high-aspect-ratio stainless steel microelectrode arrays (MEAs), 3D printed using micro laser sintering from stainless steel powder with 5μm vertical and 30μm lateral resolution. The electrical and mechanical characteristics of printed 316L and 17-4PH steel are investigated, measuring sintered metal densities greater than 95% of bulk and a 4-point electrical resistivity of 114μΩ-cm and 95μΩ-cm, respectively. One hundred element (10 by 10) MEAs with 1.5mm tall tapered electrodes are realized via interlocking sacrificial supports, which protects electrode geometries during manufacturing, thus enabling customizable 3D microelectrode arrays applications such as biomedical implants.
LSB-coded modulation and its applications to microwave digital radios (2002)

We present a forward error correction (FEC) scheme, called LSB-coded modulation. The scheme combines coding and modulation based on the observation that the symbol errors mostly occur due to the mix-up of adjacent ones. It is simple to implement, efficient and flexible with different data and coding rates. It is particularly suited for high speed, bandwidth-efficient digital communication systems. We have developed practical implementation techniques, such as FEC frame synchronization and receiver carrier phase ambiguity resolution. This scheme has been successfully applied to Harris 155.52 Mbps, 128QAM 30 MHz bandwidth, SONET/SDH microwave digital radios.
A Second Major Gene Locus in Corn for Chlorotic‐Lesion Resistance to <i>Helminthosporium turicum</i><sup>1</sup> (1977)

Gene Ht2 that conditions a form of chlorotic‐lesion resistance to Helminthosporium turcicum Pass , was identified in the Australian dent corn ( Zea mays L.) inbred NN14. Inbred NN14 also carries a second gene at the Ht locus. The two genes are not linked. Gene Ht2 conditions a lower level of resistance than does Ht but the two genes interact together to condition a higher level of resistance than either gene alone.
Isomers of hexadecenoic and hexadecadienoic acids in <i>Androsace septentrionalis</i> (Primulaceae) seed oil (2003)

Seeds of Androsace septentrionalis of the genus Androsace (tribus Primuleae) from the plant family Primulaceae were studied for their oil content and FA composition. The seed oil of A. septentrionalis was found to contain two unusual FA rarely occurring in plants: 11-cis-hexadecenoic acid (16:1delta11c or 16:1n-5) and 9-cis,12-cis-hexadecadienoic acid (16:2delta9c,12c or 16:2n-4). It also contained an unusually high amount (21.4%) of 9-cis-hexadecenoic acid (palmitoleic acid; 16:1delta9c or 16:1n-7), i.e., at a level higher than that of oleic acid, in addition to common FA. Compared with most plant seed oils, at 3.8% the level of 18:1delta11c (or 18:1n-7) also was elevated. The nonidentity of the Androsace 16:2-acid with the 16:2-acid, which is very typical for Ranunculus spp., as well as its identity with the 16:2-acid typically found in Asclepiadaceae was established by co-chromatography. The structure and composition of the constituent FA of A. septentrionalis were also determined by various chromatographic methods (TLC, Ag+-TLC, capillary GLC) and spectroscopic methods (IR, GC-MS). The significant deviation of the Androsace FA pattern from that of other Primuleae, indicating a separate phylogenetic position of Androsace, is discussed.