gebhart/patrepeval huggingface dataset:
CHRONIC VASOMOTOR RHINITIS: Treatment by Submucous Diathermic Coagulation (1953)

VASOMOTOR rhinitis is probably the commonest nasal ailment, although the present concept of the term is relatively new. At the beginning of the century, individuals with chronic vasomotor nasal symptoms had their difficulty called chronic nasal catarrh, chronic hypertrophic rhinitis, or chronic hyperesthetic rhinitis. In the 1920's, these terms were to some extent put aside, when almost all common nasal ailments were believed to be one form or another of chronic rhinitis or chronic sinusitis. In the 1930's, there began a definite trend toward differentiating chronic vasomotor rhinitis and chronic nasal allergy from true chronic sinusitis caused by bacterial infection. More recently, particularly in the past decade, nasal allergy has been found to be actually one of a group of diseases which, individually or in combination, cause the nonspecific neurovascular phenomenon which we now describe as chronic vasomotor rhinitis. The nose as an air-conditioning unit is charged with the triple
Postmodernity, Not Learning, and the Not So Common Sense (2002)

This chapter considers several examples of how some people successfully meet the challenges of new social learning and how others do not, even when the requisite information is available and the cost of failing to learn is high. These cases highlight those aspects of everyday life that contradict the foundations of much contemporary social and political theory. The analysis also suggests the direction that new theoretical efforts should take.
A potassium-proton symport in Neurospora crassa. (1986)

Combined ion flux and electrophysiological measurements have been used to characterized active transport of potassium by cells of Neurospora crassa that have been moderately starved of K+ and then maintained in the presence of millimolar free calcium ions. These conditions elicit a high-affinity (K1/2 = 1-10 microM) potassium uptake system that is strongly depolarizing. Current-voltage measurements have demonstrated a K+-associated inward current exceeding (at saturation) half the total current normally driven outward through the plasma membrane proton pump. Potassium activity ratios and fluxes have been compared quantitatively with electrophysiological parameters, by using small (approximately 15 micron diam) spherical cells of Neurospora grown in ethylene glycol. All data are consistent with a transport mechanism that carries K ions inward by cotransport with H ions, which move down the electrochemical gradient created by the primary proton pump. The stoichiometry of entry is 1 K ion with 1 H ion; overall charge balance is maintained by pumped extrusion of two protons, to yield a net flux stoichiometry of 1 K+ exchanging for 1 H+. The mechanism is competent to sustain the largest stable K+ gradients that have been measured in Neurospora, with no direct contribution from phosphate hydrolysis or redox processes. Such a potassium-proton symport mechanism could account for many observations reported on K+ movement in other fungi, in algae, and in higher plants.
Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease (2011)

Phosphodiesterase 4 (PDE4) is a member of the PDE enzyme superfamily that inactivates cyclic adenosine monophosphate and cyclic guanosine monophosphate, and is the main PDE isoenzyme occurring in cells involved in inflammatory airway disease such as chronic obstructive pulmonary disease (COPD). COPD is a preventable and treatable disease and is characterized by airflow obstruction that is not fully reversible. Chronic progressive symptoms, particularly dyspnoea, chronic bronchitis and impaired overall health are worse in those who have frequent, acute episodes of symptom exacerbation. Although several experimental PDE4 inhibitors are in clinical development, roflumilast, a highly selective PDE4 inhibitor, is the first in its class to be licensed, and has recently been approved in several countries for oral, once-daily treatment of severe COPD. Clinical trials have demonstrated that roflumilast improves lung function and reduces exacerbation frequency in COPD. Furthermore, its unique mode of action may offer the potential to target the inflammatory processes underlying COPD. Roflumilast is effective when used concomitantly with all forms of bronchodilator and even in patients treated with inhaled corticosteroids. Roflumilast thus represents an important addition to current therapeutic options for COPD patients with chronic bronchitis, including those who remain symptomatic despite treatment. This article reviews the current status of PDE4 inhibitors, focusing on the pharmacokinetics, efficacy and safety of roflumilast. In particular, it provides an overview of the effects of roflumilast on lung function and exacerbations, glucose homoeostasis and weight loss, and the concomitant use of long-acting beta(2)-adrenergic receptor agonists and short-acting muscarinic receptor antagonists.
Synthesis and in‐vitro antifungal activity of 6‐trifluoromethylpyrazolo[3,4‐d]pyrimidines (1989)

Abstract Thirty 6‐trifluoromethylpyrazolo[3,4‐d]pyrimidines were synthesised and tested for antifungal activity in vitro against ten phytopathogenic fungi of different taxonomic classes. Six of the compounds had noteworthy activity against Sclerotinia minor, Corticium solani and Phoma betae. The relationships between structure and activity are discussed on the basis of the present and previous studies.
Effect of Carbon Black on Properties of Soils (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of Carbon Black on Properties of SoilsJohn N. Everson and James B. WeaverCite this: Ind. Eng. Chem. 1949, 41, 8, 1798–1801Publication Date (Print):August 1, 1949Publication History Published online1 May 2002Published inissue 1 August 1949https://pubs.acs.org/doi/10.1021/ie50476a065https://doi.org/10.1021/ie50476a065research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effects of Several Plant Growth-Regulators on Wound Healing of Sugar Maple (1949)

1. Six growth-regulating substances (3-indolebutyric acid, o-chlorophenoxy-propionic acid, 2,4-dichlorophenoxyacetic acid, p-chlorophenoxyacetic acid, traumatic acid, and glutathione) were tested for their abilities to stimulate the wound healing of sugar maple (Acer saccharum Marsh). 2. Glutathione at 50 and 100 mg/gm talc was found to have a stimulating effect. 3. The other compounds at the concentrations tested were not found to stimulate healing. 4. It is indicated that -SH-containing compounds might be of practical importance when incorporated in wound dressings.
Tap-to-Pair (2018)

Ad-hoc wireless device pairing enables impromptu interactions in smart spaces, such as resource sharing and remote control. The pairing experience is mainly determined by the device association process, during which users express their pairing intentions between the advertising device and the scanning device. Currently, most wireless devices are associated by selecting the advertiser's name from a list displayed on the scanner's screen, which becomes less efficient and often misplaced as the number of wireless devices increases. In this paper, we propose Tap-to-Pair, a spontaneous device association mechanism that initiates pairing from advertising devices without hardware or firmware modifications. Tapping an area near the advertising device's antenna can change its signal strength. Users can then associate two devices by synchronizing taps on the advertising device with the blinking pattern displayed by the scanning device. By leveraging the wireless transceiver for sensing, Tap-to-Pair does not require additional resources from advertising devices and needs only a binary display (e.g. LED) on scanning devices. We conducted a user study to test users' synchronous tapping ability and demonstrated that Tap-to-Pair can reliably detect users' taps. We ran simulations to optimize parameters for the synchronization recognition algorithm and provide pattern design guidelines. We used a second user study to evaluate the on-chip performance of Tap-to-Pair. The results show that Tap-to-Pair can achieve an overall successful pairing rate of 93.7% with three scanning devices at different distances.
Recrystallization of Drugs: Significance on Pharmaceutical Processing (2012)

Not surprisingly, the wide range of effective medicinal agents available today is one of the greatest scientific achievements. Regardless of the advancements in effectiveness and safety of the medicines embedded in dosage forms, the pharmaceutical concept of the latter is growing to be ever more eminent (Adibkia et al., 2011). Following on from recent advancements, in a time of increased considerations to the level of sophistication in designing pharmaceutical dosage forms keeping pace with advances in drug discovery methods, it seems as important as ever to study the physicochemical properties of active pharmaceutical ingredients, prerequisite for a successful product formulation.
Quality mesh generation in three dimensions (1992)

We show how to triangulate a three dimensional polyhedral region with holes. Our triangulation is optimal in the following two senses. First, our triangulation achieves the best possible aspect ratio up to a constant. Second, for any other triangulation of the same region into m triangles with bounded aspect ratio, our triangulation has size n = O(m). Such a triangulation is desired as an initial mesh for a finite element mesh refinement algorithm. Previous three dimensional triangulation schemes either worked only on a restricted class of input, or did not guarantee well-shaped tetrahedra, or were not able to bound the output size. We build on some of the ideas presented in previous work by Bern, Eppstein, and Gilbert, who have shown how to triangulate a two dimensional polyhedral region with holes, with similar quality and optimality bounds.
Deterministic perturbation gradient approximation for transmission subspace tracking in FDD-CDMA (2004)

Multiple antenna transmission promises to bring substantial capacity benefits to wireless communication systems. Knowledge of the channel can be used to further improve the communication. In frequency division duplex channels, such knowledge can be obtained using feedback. The feedback bandwidth is limited, hence efficient feedback of such channel information to the transmitter is required. This paper proposes one such method based on subspace tracking principles. A perturbation vectors is used to approximate the gradient of the cost function. Simulation results show good performance when there is temporal or spatial correlation in the channel.
Quantitative Determination of High Molecular WeightAlkaline Phosphatase in Patients with Colorectal Cancer byPolyacrylamide Gel Electrophoresis (1990)

We present a new method for the quantitative determination of high molecular weight alkaline phosphatase (ALP). This method consists of electrophoretic separation on polyacrylamide, incubation of the ALP isoenzymes with substrate, gel drying and quantitative evaluation by densitometric measurement. This method separates high molecular weight ALP from the other isoenzymes. Precision of the method is calculated by the coefficient of variation ranging from 1.2 to 9.5% for samples with different high molecular weight ALP values. The diagnostic sensitivity for detecting colorectal cancer is 60%.
GDH3 encodes a glutamate dehydrogenase isozyme, a previously unrecognized route for glutamate biosynthesis in Saccharomyces cerevisiae (1997)

It has been considered that the yeast Saccharomyces cerevisiae, like many other microorganisms, synthesizes glutamate through the action of NADP+-glutamate dehydrogenase (NADP+-GDH), encoded by GDH1, or through the combined action of glutamine synthetase and glutamate synthase (GOGAT), encoded by GLN1 and GLT1, respectively. A double mutant of S. cerevisiae lacking NADP+-GDH and GOGAT activities was constructed. This strain was able to grow on ammonium as the sole nitrogen source and thus to synthesize glutamate through an alternative pathway. A computer search for similarities between the GDH1 nucleotide sequence and the complete yeast genome was carried out. In addition to identifying its cognate sequence at chromosome XIV, the search found that GDH1 showed high identity with a previously recognized open reading frame (GDH3) of chromosome I. Triple mutants impaired in GDH1, GLT1, and GDH3 were obtained. These were strict glutamate auxotrophs. Our results indicate that GDH3 plays a significant physiological role, providing glutamate when GDH1 and GLT1 are impaired. This is the first example of a microorganism possessing three pathways for glutamate biosynthesis.
An Ultra-Wide-Band 0.4&ndash;10-GHz LNA in 0.18-<formula formulatype="inline"><tex>$\mu$</tex></formula>m CMOS (2007)

A two-stage ultra-wide-band CMOS low-noise amplifier (LNA) is presented. With the common-gate configuration employed as the input stage, the broad-band input matching is obtained and the noise does not rise rapidly at higher frequency. By combining the common-gate and common-source stages, the broad-band characteristic and small area are achieved by using two inductors. This LNA has been fabricated in a 0.18-mum CMOS process. The measured power gain is 11.2-12.4 dB and noise figure is 4.4-6.5 dB with -3-dB bandwidth of 0.4-10 GHz. The measured IIP3 is -6 dBm at 6 GHz. It consumes 12 mW from a 1.8-V supply voltage and occupies only 0.42 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>
Slow waves trapped in a fluid‐filled infinite crack: Implication for volcanic tremor (1987)

The dynamics and seismic radiation of fluid‐filled cracks have been studied by numerous authors, as models for tremor and for long‐period events observed at volcanoes. One of the most intriguing results of the recent models is the existence of a very slow wave propagating along the crack boundary. In order to better understand this slow wave, which has so far only been studied numerically, we studied analytically normal modes trapped in a liquid layer sandwiched between two solid half‐space. A slow wave, similar to the tube wave found by Biot, exists for all wavelengths. In the short wavelength limit, this wave approaches the Stoneley wave for the liquid‐solid interface. Unlike the tube wave, however, as the wavelength increases to infinity, both the phase and group velocities approach zero, in inverse proportion to the square root of wavelength. The phase velocity and amplitude of this slow wave are in good agreement with those obtained by the numerical studies on the dynamics of fluid‐filled cracks by two dimensional and three‐dimensional finite difference methods. In the past the size of a magma body has been estimated from volcanic tremor periods and the acoustic velocity in the fluid. These estimates should be drastically reduced if the slow wave dominates the tremor. For example, the extremely long‐period volcanic tremor, with periods up to 7s, observed at Mount Aso may be generated by a fluid‐filled crack of modest size, a magma body 0.5 m thick and 0.5 km long.
Voltage Mode OTRA MOS-C Single Input Multi Output Biquadratic Universal Filter (2012)

In this paper, an Operational transresistance amplifier (OTRA) based MOS-C voltage mode single input multi output (SIMO) biquadratic universal filter configuration is proposed. The configuration is made fully integrated by implementing the resistors using matched transistors operating in the linear region. It exhibits the feature of orthogonal controllability of angular frequency and quality factor through gate bias voltage. The non-ideality analysis of the circuit is also given. Workability of the universal filter is demonstrated through PSPICE simulations using 0,5 μm CMOS process parameters provided by MOSIS (AGILENT).
Studying the multilevel impact of cohesion versus structural holes in knowledge networks on adaptation to IT‐enabled patient‐care practices (2019)

Abstract We investigate the impact of cohesion versus structural holes in two different types of knowledge networks—help‐seeking networks and voluntary contribution networks—on adaptation to health IT‐enabled patient‐care practices. In a multimethod study conducted within a large hospital system, qualitative and quantitative data were collected from 806 clinicians working with electronic medical record systems in 27 inpatient patient‐care units. Multilevel analysis of the data revealed that overall network cohesiveness versus location in structural hole positions related to adaptation differently, depending on the type of network. In help‐seeking networks, location in structural hole positions was negatively related to adaptation, while network cohesion had a bell‐shaped curvilinear relationship with adaptation; in voluntary contribution networks, the overall cohesiveness of the network was negatively related to adaptation, but location in structural hole positions was irrelevant to adaptation. Our findings suggest a more nuanced way of monitoring and utilising different sets of informal social interactions at work to maximise employees' adaptation to IT‐enabled work.
The Research and Development of COM-PLY Lumber (1989)

Between 1974 and 1986, a Southeastern Station Research Work Unit developed standards for composite studs, joists, and truss lumber and manufactured and demonstrated the materials. Economic feasibility was considered in every stage of research. Further development is left to industry.
Multi-impairments monitoring from the equalizer in a digital coherent optical receiver (2010)

We propose a simple and precise algorithm to monitor multiple impairments such as CD, PMD, and PDL, which are jointly mitigated in the adaptive equalizer of a digital coherent optical receiver. We validate our algorithm by dual-polarization QPSK transmission experiments.
Chemoenzymatic Route to S-Betaxolol (2011)

Abstract An efficient chemoenzymatic route to S-betaxolol is reported. A strain (Rhodotorula mucilaginosa DQ832198) screened from soil was used as biocatalyst for the kinetic resolution of the key acetylated intermediates. Excellent enantiomeric excess (ee > 99%) was obtained under very mild conditions. The biocatalyst is quite stable and could be used several times with little decrease of the resolving ability.
Authenticated location in wireless mesh networks (2006)

Location is part of the context of an ensemble of mobile nodes in a wireless mesh network. In this paper we present a concept and an architecture for a location aware Digital Rights Management system. This system uses signal strengths in a mobile ad-hoc or mesh network to determine the position of each node and to authenticate these position information. It enables devices to control access depending on their position. We describe algorithms, protocols, security threats, and a prototype.
Design and Construction of Solid State Ag/AgCl Reference Electrodes Through Electrochemical Deposition of Ag and AgCl Onto a Graphite/Epoxy Resin-Based Composite. Parte 1: Electrochemical Deposition of Ag Onto a Graphite/Epoxy Resin-Based Composite (2011)

In order to design and build solid state Ag/AgCl reference electrodes, the thick-film and thin-film techniques are frequently used to obtain a silver coating on a substrate that is subsequently chlorinated. In this part of the work we propose the use of a graphite/epoxy resin-based composite to electrodeposit silver onto its surface; to produce the said silver coating, we carried out potentiodynamic and potentiostatic studies of the silver electrodeposition process. The results obtained indicate a 3D silver nucleation and growth mechanism controlled by diffusion. Also it became apparent that obtaining a surface with variable roughness enables the deposition of up to a 100% more silver on the composites used. The present study has been carried out with the aim of obtaining design parameters to construct a silver coating reference solid state electrode as an alternative to thick and thin-film electrodes.
Depression and inflammatory bowel disease: Findings from two nationally representative Canadian surveys (2006)

Most studies of depression and inflammatory bowel disease (IBD) have been drawn from clinical populations or from samples selected from the membership of Crohn's and ulcerative colitis community organizations. This study determined the prevalence and correlates of depression in people with IBD or a similar bowel disorder from 2 nationally representative Canadian surveys. In the Canadian Community Health Survey, conducted in 2000 through 2001, there were 3076 respondents who reported that they had "a bowel disorder such as Crohn's disease or colitis" that had lasted >or=6 months and had been diagnosed by a health professional. The National Population Health Survey, conducted from 1996 through 1997, had 1438 respondents who reported that they had such a condition. Within each subsample, bivariate analyses were conducted to compare the depressed and nondepressed individuals. Logistic regression analyses also were conducted using the Canadian Community Health Survey 1.1 data set. The 12-month period prevalence of depression among individuals with IBD and similar bowel disorders was comparable in the 2 data sets (16.3% and 14.7%). Depression rates were higher among female respondents, those without partners, younger respondents, those who reported greater pain, and those who had functional limitations. Seventeen percent of depressed respondents had considered suicide in the past 12 months; an additional 30% had considered suicide at an earlier time. Only 40% of depressed individuals were using antidepressants. Individuals with IBD and similar bowel disorders experience rates of depression that are triple those of the general population. It is important for clinicians to assess depression and suicidal ideation among their patients with active IBD symptoms, particularly among those reporting moderate to severe pain.