gebhart/patrepeval huggingface dataset:
Experimental and Numerical Flutter Investigation of the 1st Stage Rotor in 4-Stage High Speed Compressor (2008)

Experimental tests were performed to investigate flutter behaviour of the transonic rotor in a high-speed multistage compressor test facility. Besides the acquisition of overall performance parameters the rig was equipped with special instrumentation such as strain gauges, tip-timing system and dynamic pressure transducers. The 4-stage compressor comprises 3 variable vanes. The instrumentation was able to measure stall and flutter and forced responses of the rotor blades. The experimental data was used to validate the in-house aeroelastic solver. During testing flutter was triggered intentionally at part speed conditions with malscheduled variable vanes. The malschedule changed the flow incidences for the relevant rotor and induced flutter. An aeroelastic simulation was set up according to the flutter conditions found during the experiment. The measured boundary conditions were used to set up the aeroelastic simulation. The calculation shows the torsion mode with a negative aerodynamic damping which confirms the test results. The only difference between test and prediction is the nodal diameter, at which the flutter occurs.
Characterization and expression of adjacent proline iminopeptidase and aspartase genes from <i>Eikenella corrodens</i> (2003)

Two adjacent genes involved in nitrogen metabolism from Eikenella corrodens, with a potential role in pathogenesis, were studied. Proline iminopeptidase (Pip) activity, which may be essential for energy production and protection against host immune mechanisms, is exhibited by E. corrodens. Analysis of Pip-expressing clones revealed an ORF of 939 bases with a predicted amino acid sequence identity of 67% to the Pip of Neisseria gonorrhoea. 200 bp downstream from pip, an ORF of 1395 bases, encoding a protein with 87% identity to a putative aspartase from the Neisseria meningitidis genome sequence, was identified. Enzymatic function was confirmed with a complemented Escherichia coli aspartase deficient mutant. The E. corrodens aspartase was found to be 77% identical to the Haemophilus influenzae aspartase sequence, which was originally identified on the basis of its ability to bind plasminogen. However, the E. corrodens aspartase had no such activity. Southern hybridization indicated both genes to be single copy and conserved within the genomes of a diverse panel of E. corrodens isolates from health and disease.
Reproducible Community Dynamics of the Gastrointestinal Microbiota following Antibiotic Perturbation (2009)

Shifts in microbial communities are implicated in the pathogenesis of a number of gastrointestinal diseases, but we have limited understanding of the mechanisms that lead to altered community structures. One difficulty with studying these mechanisms in human subjects is the inherent baseline variability of the microbiota in different individuals. In an effort to overcome this baseline variability, we employed a mouse model to control the host genotype, diet, and other possible influences on the microbiota. This allowed us to determine whether the indigenous microbiota in such mice had a stable baseline community structure and whether this community exhibited a consistent response following antibiotic administration. We employed a tag-sequencing strategy targeting the V6 hypervariable region of the bacterial small-subunit (16S) rRNA combined with massively parallel sequencing to determine the community structure of the gut microbiota. Inbred mice in a controlled environment harbored a reproducible baseline community that was significantly impacted by antibiotic administration. The ability of the gut microbial community to recover to baseline following the cessation of antibiotic administration differed according to the antibiotic regimen administered. Severe antibiotic pressure resulted in reproducible, long-lasting alterations in the gut microbial community, including a decrease in overall diversity. The finding of stereotypic responses of the indigenous microbiota to ecologic stress suggests that a better understanding of the factors that govern community structure could lead to strategies for the intentional manipulation of this ecosystem so as to preserve or restore a healthy microbiota.
Contrast-Enhanced Microcomputed Tomography Using Intraperitoneal Contrast Injection for the Assessment of Tumor-Burden in Liver Metastasis Models (2008)

The combination of IP iohexol with Fenestra provides superior delineation of liver tumors, in comparison to Fenestra alone. The complete tumor delineation provided by this imaging strategy allows for noninvasive quantification of liver tumor-burden.
Ultra Stable Semiconductor Laser Current Source (2006)

Life-test for high reliability laser pumps demands highly stable current sources. Telops has engineered a novel current source that meets stabilities of 200 ppm/1000hr. This paper presents the design and assessment of performance
Partial widths of the resonances of the H<sup>-</sup><sup>1</sup>P<sup>0</sup>two-electron ionization ladder (1992)

The resonance wavefunctions of two-electron ionization ladder (TEIL) states can be identified a priori and computed to a high degree of accuracy from the solution of the complex eigenvalue Schrodinger equation. Depending on the form of the trial functions and on the concomitant non-Hermitian matrices, energies, energy shifts and partial widths can be obtained. The authors present the first predictions for the partial widths of the 1P0 TEIL states in H-, for n=3, 4 and 5, from calculations which include interchannel coupling. As before for the 1S symmetry, their analysis of the decay distribution shows that most of the width goes to the nearest hydrogenic threshold, while within each threshold there is strong mixing of the angular momentum channels. As n increases, the lifetime increases while it is given with increasing accuracy by the decoupled width (i.e. golden rule) to the nearest hydrogenic threshold.
Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis (2011)

Metastasis is the main cause of death for cancer patients. Targeting factors that control metastasis formation is a major challenge for clinicians. Lysophosphatidic acid (LPA) is a bioactive phospholipid involved in cancer. LPA activates at least six independent G protein-coupled receptors (LPA1-6). Tumor cells frequently co-express multiple LPA receptors, puzzling the contribution of each one to cancer progression. All three receptors, LPA1, LPA2 and LPA3, act as oncogenes and prometastatic factors in the mouse mammary gland. The competitive inhibitor of LPA1 and LPA3 receptors, Ki16425, inhibits efficiently breast cancer bone metastases in animal models. We showed here that Debio 0719, which corresponds to the R-stereoisomer of Ki16425 exhibited highest antagonist activities at LPA1 (IC50=60 nM) and LPA3 (IC50=660 nM) than Ki16425 [IC50=130 nM (LPA1); IC50=2.3 µM (LPA3)]. In vitro, Debio 0719, inhibited LPA-dependent invasion of the 4T1 mouse mammary cancer cells. In vivo, early but not late administration of Debio 0719 (50 mg/kg p.o. twice daily) to BALB/c mice during the course of orthotopic 4T1 primary tumor growth reduced the number of spontaneously disseminated tumor cells to bone and lungs without affecting the growth of primary tumors and tumor-induced angiogenesis. We found that increased LPA1 mRNA expression in primary tumors of breast cancer patients correlated significantly with their positive lymph node status (p<0.001). Altogether, our results suggest that LPA1 controls early events of metastasis independently of cell proliferation and angiogenesis. Therefore, targeting this receptor with Debio 0719 has a high therapeutic potential against metastasis formation for breast cancer patients.
Histidine‐419 plays a role in energy coupling in the vesicular monoamine transporter from rat (1994)

Vesicular monoamine transporters (VMAT) catalyze transport of serotonin, dopamine, epinephrine and norepinephrine into subcellular storage organelles in a variety of cells. Accumulation of the neurotransmitter depends on the proton electrochemical gradient across the organelle membrane and involves VMAT-mediated exchange of two lumenal protons with one cytoplasmic amine. It has been suggested in the past that His residues play a role in H+ movement or in its coupling to active transport in H(+)-symporters and antiporters. Indeed VMAT-mediated transport is inhibited by reagents specific for His residues. We have identified one His residue in VMAT1 from rat which is conserved in other vesicular neurotransmitter transporters. Mutagenesis of this His (H419) to either Arg or Cys completely inhibits [3H]serotonin and [3H]dopamine accumulation. Mutagenesis also inhibits other H(+)-dependent partial reactions of VMAT such as the acceleration of binding of the high affinity ligand reserpine, but does not inhibit the [3H]reserpine binding which is not dependent on H+ translocation. It is concluded that His-419 plays a role in energy coupling in r-VMAT1.
NEESR-Adapt-Struct: Semi-Active Control of ASD Device—Adaptive Length Pendulum Dampers (2010)

Tuned mass dampers (TMD), active mass dampers (AMD) and hybrid mass dampers (HMD) have been widely applied for vibration control of tall buildings and bridges in the past decade. Recently, the first author and his coworkers have developed semiactive or smart tuned mass dampers (STMD) using semiactive variable stiffness systems. STMD's are superior then TMD's in reducing the response of the primary structure. In case the fundamental frequency of the primary structure changes due to damage or deterioration, then the TMD will be off-tune; hence, it will lose its effectiveness significantly, whereas the STMD is robust against such changes as it is always tuned. The author and his coworkers have shown that STMD can provide performance similar to AMD/HMD, but with an order of magnitude less power consumption. This paper presents the development of a new STMD to reduce the vibrations of structures. The new STMD is an adaptive length pendulum (ALP) damper. It is essentially an Adaptive Stiffness Device (ASD); wherein, the length of the pendulum is varied in real time to achieve the change in frequency or stiffness (with mass remaining constant) of the pendulum. The Two different control approaches to adjust the length of pendulum of the ALP-STMD are developed (1) a shape memory alloy (SMA) actuator, and (2) servomotor. In both the mechanisms the length of the pendulum is adjusted semi-actively based on the feedback signal displacement of the top floor of the structure. Experimental studies are carried on a two-storey scaled model building with ALP-STMD. Effectiveness of the proposed ALP-STMD in controlling the fundamental mode of the structure is validated experimentally using both the SMA and servomotor to change its length. Off-tuned ALP-STMD results are presented to demonstrate the importance of tuning the length of pendulum.
<i>N</i>-(4-Fluorophenyl)-4-nitrophthalimide: tripartite hydrogen-bonded sheets (2004)

Molecules of the title compound, C14H7FN2O4, are linked by two C-H...O hydrogen bonds [H...O = 2.42 and 2.44 A, C...O = 3.173 (9) and 3.313 (10) A, and C-H...O = 134 and 157 degrees] into deep tripartite sheets, where the central layer is built from hydrogen-bonded R(6)6(24) rings and where the F atoms all lie on the exterior surfaces of the sheets.
A new technique for multiparameter imaging microscopy: Use of long decay time photoluminescent labels enables multiple color immunocytochemistry with low channel‐to‐channel crosstalk (2003)

In this report, we describe luminescence imaging microscopy using five different photoluminescent dyes in a single specimen. We combined the long decay time luminophores, europium(III) chelate, terbium(III) chelate, palladium(II) coproporphyrin, and platinum(II) coproporphyrin, with a green nuclear stain, Syto 25 trade mark, that emits conventional fast decaying fluorescence. The luminescence emissions from the five different luminophores were separated from each other by the differences in spectra and decay times using time-resolved detection. Applicability of this dye-combination for multiparameter analysis of a biological object was verified in a mixed population of peripheral blood leukocytes. Leukocyte cytocentrifugates were incubated in one step with a cocktail of luminophore-conjugated antibodies recognizing neutrophil- and lymphocyte-specific markers, followed by rapid staining with a mixture of nuclear stain and Pt-porphyrin as an eosinophil stain. The results show that multiple luminescent dyes with long decay time can be used together, and in combination with a conventional fluorophore. The separation of the signals of the long decay time labels was distinctive and enabled reliable identification of different leukocyte types, as well as an automated cell count. The long decay time luminophores together with time-resolved luminescence imaging microscopy (TR-LIM) provide a unique tool for studies of simultaneous expression of multiple antigens at the level of a single cell. In comparison with other multiparameter imaging techniques, the described technique offers increased accuracy of results, simplification of preparation procedure, and dramatic shortening of the total processing time. To our knowledge, this is the first time that simultaneous fivefold labeling/staining and analysis in a single specimen has been performed in the field of immunocytochemistry.
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x<sub>L</sub> (1999)

Fas activation triggers apoptosis in many cell types. Studies with anti-Fas antibodies have produced conflicting results on Fas signaling, particularly the role of the Bcl-2 family in this process. Comparison between physiological ligand and anti-Fas antibodies revealed that only extensive Fas aggregation, by membrane bound FasL or aggregated soluble FasL consistently triggered apoptosis, whereas antibodies could act as death agonists or antagonists. Studies on Fas signaling in cell lines and primary cells from transgenic mice revealed that FADD/MORT1 and caspase-8 were required for apoptosis. In contrast, Bcl-2 or Bcl-x(L) did not block FasL-induced apoptosis in lymphocytes or hepatocytes, demonstrating that signaling for cell death induced by Fas and the pathways to apoptosis regulated by the Bcl-2 family are distinct.
Optical properties of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">La</mml:mi></mml:mrow><mml:mrow><mml:mn>1.85</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Sr</mml:mi></mml:mrow><mml:mrow><mml:mn>0.15</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">CuO</mml:mi></mml:mrow><mml:mrow><mml:mn>4</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>: Evidence for strong electron-phonon and electron-electron interactions (1987)

The optical properties of the high-${T}_{c}$ superconductor ${\mathrm{La}}_{1.85}$${\mathrm{Sr}}_{0.15}$${\mathrm{CuO}}_{4}$ have been measured over the far-infrared through ultraviolet frequency range at temperatures between 4 and 300 K. The frequency-dependent conductivity shows strong vibrational features in the far infrared (240, 355, and 495 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$) and two electronic transitions in the infrared (3500 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$/0.44 eV and 10 500 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$/1.3 eV). The measurements are interpreted within a model of strongly correlated electrons interacting strongly with vibrational modes.
Zusammenfassung (1977)

Es wurde der Lärm untersucht, welcher bei Umlenkung eines Luftstrahls durch ein Hindernis entsteht. Hierbei ergab sich eine starke Lärmsteigerung durch akustische Rückkopplung zwischen Wirbeln in der freien Strahlgrenzschicht und vom Hindernis ausgehenden Schallwellen.
The Earthquake Barrier (1986)

The earthquake barrier protects buildings from the horizontal ground vibrations of an earthquake by installing a 'force barrier and an energy barrier' at the underside of the building. The earthquake barrier gives the structural engineer control over the forces of nature. To accomplish this, low friction teflon slide plates are first inserted under each column and wall to destroy the grip that the foundation of a conventional building has on the superstructure. Having destroyed the shear transfer at the foundation, it can then be replaced by inserting high-friction prestressed slide plates that firmly tie the building back to its foundation. The earthquake barrier system is a combination of these two simple and reliable devices.
Conjugation of catalase to a carrier antibody via a streptavidin-biotin cross-linker. (1997)

Targeting of catalase could be useful in antioxidative protection of cells challenged with H2O2. In the present study we conjugated catalase to a carrier model antibody using a biotin-streptavidin (SA) cross-linker and characterized the functional activity of the conjugate. Neither biotinylation nor conjugation with SA decreased the enzymic activity of catalase. Further coupling of radiolabelled biotinylated catalase (b-catalase) to biotinylated antibody (b-Ab) via SA using a two-step conjugation procedure did not change enzymic activity of b-catalase. b-Ab-SA-b-catalase specifically bound to antigen-coated plastic wells, but not to albumin-coated plastic wells. Substitution of b-Ab with control biotinylated IgG (b-IgG) abrogated binding of the catalase to the antigen. H2O2 was degraded in antigen-coated wells preincubated with b-Ab-SA-b-catalase, but not with b-IgG-SA-b-catalase. Thus b-Ab-SA-b-catalase specifically binds to immobilized antigen and degrades H2O2 after binding to the target. The methodology described in the present paper may be useful for the development of a novel strategy for antioxidant therapy.
Sense codon emancipation for proteome-wide incorporation of noncanonical amino acids (2014)

One of the major challenges in contemporary synthetic biology is to find a route to engineer synthetic organisms with altered chemical constitution. In terms of core reaction types, nature uses an astonishingly limited repertoire of chemistries when compared with the exceptionally rich and diverse methods of organic chemistry. In this context, the most promising route to change and expand the fundamental chemistry of life is the inclusion of amino acid building blocks beyond the canonical 20 (i.e. expanding the genetic code). This strategy would allow the transfer of numerous chemical functionalities and reactions from the synthetic laboratory into the cellular environment. Due to limitations in terms of both efficiency and practical applicability, state-of-the-art nonsense suppression- or frameshift suppression-based methods are less suitable for such engineering. Consequently, we set out to achieve this goal by sense codon emancipation, that is, liberation from its natural decoding function - a prerequisite for the reassignment of degenerate sense codons to a new 21st amino acid. We have achieved this by redesigning of several features of the post-transcriptional modification machinery which are directly involved in the decoding process. In particular, we report first steps towards the reassignment of 5797 AUA isoleucine codons in Escherichia coli using efficient tools for tRNA nucleotide modification pathway engineering.
Transmission Electron Microscopy of Granular Nickel/SiO2 Cermet Films (1972)

Granular nickel films have been prepared by co-sputtering nickel and silica onto glass substrates at room temperature. Seven films of (Ni)1−x(SiO2)x, where x is the volume fraction of silica, were examined by transmission electron microscopy. For all samples, the microstructure consisted of nickel grains embedded in a matrix of silica. The grain size is observed to decrease linearly with x; the distribution of grain sizes varies from 170 to 310 Å for x≃0.1 and from 40 to 55 Å for x≃0.75. The thickness of the intergranular silica is about 22 Å and is independent of composition. The nickel lattice is observed to expand with increasing x; the fractional expansion is inversely proportional to grain size and attains values as large as 10% for large x. These results will prove useful in the interpretation of the magnetic, electrical, and optical properties of granular metal films. In particular, these results have been applied to the interpretation of the depression in magnetic Curie temperature observed in the (Ni)1−x(SiO2)x system.
Joint channel estimation and equalization algorithm for DTMB receivers (2013)

This paper presents a joint channel estimation and equalization algorithm for Chinese Digital Terrestrial Multimedia Broadcasting (DTMB) system. The initial channel estimation is carried out using PN sequence, then the frame header (FH) is eliminated from the received data and the frame body (FB) is obtained. After a one-tap frequency domain equalizer, the equalized data is fed into a proposed tracking loop to refine the channel estimation. Simulation results have proved the good performance in both static and dynamic propagation environments for DTMB receivers.
Mesothelial cyst arising from the anterior superior mediastinum which can be resected through thorascope; a case report. (1996)

症例は74歳, 女性.1993年9月胸部X線写真上異常を指摘され, 当院へ紹介された.胸部CT, MRIで, 右前上縦隔に径3cm大の嚢胞性腫瘤を認めた.胸腺嚢胞の術前診断にて, 胸腔鏡による腫瘤摘出術を行なった.病理組織検査では, 腫瘍は一層から数層の中皮様細胞によって内面を覆われ, 明らかな胸腺組織はなかったことからmesothelial cyst と診断された。Mesothelial cyst は先天性嚢胞の1つであり, 2種類に分類されている.嚢胞が心膜に接している時は心膜嚢腫と呼ばれ, それ以外の場所に存在する時は胸膜嚢腫, もしくは狭義のmesothelial cystと呼ばれる.好発性部位は, 心横隔膜角部とされており前上縦隔に発生することは稀である.前上縦隔に発生する嚢胞性病変は術前診断が時として困難であるため, 診断と治療を兼ねて摘出術が行われる.胸腔鏡下手術は従来の開胸術に比べて低侵襲であり, その適応は広がってきている.本症例に対しても胸腔鏡下手術が有用であった.
Syntheses of heterocyclic compounds CCCXCVI. Alternative total synthesis of (+-)-galanthamine (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of heterocyclic compounds CCCXCVI. Alternative total synthesis of (+-)-galanthamineTetsuji Kametani, Khozo Shishido, E. Hayashi, C. Seino, T. Kohno, Shiroshi Shibuya, and Keiichiro FukumotoCite this: J. Org. Chem. 1971, 36, 9, 1295–1297Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/jo00808a028https://doi.org/10.1021/jo00808a028research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts