gebhart/patrepeval huggingface dataset:
Double-contrast computed tomographic examination techniques in habitual and recurrent shoulder dislocation. (1988)

Preoperative planning of recurrent shoulder dislocation requires an accurate knowledge of bone and soft tissue lesions affecting the joint. A new method of double-contrast CT examination is presented which allows an accurate evaluation of the soft tissue structures important for the stability of the joint. Forty-two patients were examined with this technique, twenty-seven of whom (28 shoulders) were operated on, the procedure being selected on the basis of the CT findings. In all cases the preoperative CT findings corresponded to the intraoperative findings.
P4‐158: A low‐dose of intravenous immunoglobulin provides protection in focal and global brain ischemia models and abolishes the increased ischemic vulnerability of aged APP/PS1 mice (2009)

Stroke is a major cause of disability in the elderly. In particular, cerebrovascular lesions may contribute to the pathogenesis of Alzheimer's disease (AD), as up to 90 % of patients show cerebrovascular pathology at autopsy. Interestingly, several transgenic mouse models of AD have shown increased vulnerability to ischemia at an early age. Because recent studies indicate that clinically safe intravenous immunoglobulin (IVIG) dose of 2 g/kg provides protection against focal brain ischemia in young wild-type (wt) mice, we investigated whether IVIG could abolish the increased vulnerability to ischemic injury in aged APP/PS1 transgenic mice. We also tested the effect of IVIG in a model of global brain ischemia affecting the brain regions important for memory functions. Permanent middle cerebral artery occlusion was induced in male Balb/c, female APP/PS1 mice and their C57Bl wt controls. The mice were given an intravenous injection of 0.5 or 1.0 g/kg of IVIG (Gammagard Liquid, Baxter) or saline 1 h before or 0, 1 or 3 h after the onset of ischemia. Lesion volume was determined by T2 weighted 9.4 T MRI 24 and 72 h after the ischemia in Balb/cA mice and by TTC-staining in APP/PS1 mice and their controls. Global forebrain ischemia was induced in C57Bl/6 wt mice by reversible compression of carotid arteries. IVIG (0.5 g/kg) or saline was given 1 h after the ischemia and effect on cognitive decline was tested in Morris water maze at 14 days. Finally, delayed apoptotic death of CA1 pyramidal neurons was assessed at 15 days. IVIG provided protection against focal ischemia, especially at the dose of 0.5 g/kg when the treatment was started at or one hour after the onset of ischemia. Ischemic lesions were 58% larger in APP/PS1 mice than in controls. IVIG treatment abolished this increased ischemic vulnerability in APP/PS1 mice. IVIG group outperformed the saline group in spatial memory after the global ischemia suggesting that IVIG protects the CA1 subregion against ischemic damage. These data indicate that IVIG may be a promising new neuroprotective treatment in acute brain ischemia, and further study of this possibility is warranted. Supported by Baxter Innovations, GmbH, Austria.
The Toll-like Receptor 2/6 Ligand MALP-2 Reduces the Viability of Mycobacterium tuberculosis in Murine Macrophages (2009)

Toll-like receptors (TLRs) sense conserved structures of pathogens and influence macrophage functions. Here we investigated the impact of TLR signaling on the modulation of macrophage defense mechanisms against infection of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. We found that a synthetic derivative of the TLR2/6 agonist MALP-2 and the potent TLR4 agonist lipopolysaccharide inhibited the intracellular growth of MTB in murine macrophages. Likely the microbicidal effect was mediated by production of nitric oxide while it is still unclear the role played by release of TNF-α , IL-6, MIP-1β and IL-10. These results suggest that the activation of microbicidal defense via TLR ligands is an appealing target for the establishment on immune intervention against tuberculosis.
Induced Drag of Ground Vehicles and Its Interaction with Ground Simulation (2005)

<div class="htmlview paragraph">For the aerodynamic development of an aircraft the induced drag is an important quantity and it has a significant impact on the design of the wing. The induced drag corresponds to the power requirement of the wing to generate the necessary lift. In many cases this is the dominant source of drag for aircraft.</div> <div class="htmlview paragraph">In ground vehicle aerodynamics the concept of induced drag up to now has attracted much less attention. This is partly due to the fact, that vehicle aerodynamicists usually optimize the vehicles to generate little or no lift. The second reason is that it is much more difficult for a ground vehicle to separate the total drag into the different contributions.</div> <div class="htmlview paragraph">During wind tunnel tests of vehicles with and without ground simulation some astonishing results were found, especially when comparing results for different rear end shapes. Notchback vehicles typically displayed lower drag results when measured with ground simulation, whereas wagon backs showed higher drag figures compared with the case without ground simulation. To explain these surprising results, the contribution of induced drag to the total drag was analyzed in detail. The proportion of induced drag was determined from measured polar diagrams. Different lift levels of the vehicles were created using an adjustable rear spoiler, whereas the trim level of the vehicle was kept constant.</div> <div class="htmlview paragraph">Notchbacks typically generate rear lift and wagon backs rear downforce. The two rear end types therefore are located on different branches of the parabola describing the induced drag. By improvement of the ground simulation typically the lift is reduced and thus the induced drag is modified. Due to the difference in the basic lift level the drag is reduced for the notchback and increased for the wagon back.</div> <div class="htmlview paragraph">Induced drag can of course describe only a part of the complex influence of improved ground simulation. Notch-back vehicles do not generally show lower drag results when using ground simulation. Nevertheless induced drag can explain some significant influences found in recent test results.</div>
Greedy control for hybrid pursuit games (2001)

We address the design of optimal strategies for a pursuer trying to catch a moving evader. When the pursuer has available two teams of agents with different capabilities-one that can "search for the evader" and the other one that can "catch the evader"-, the game can be naturally formulated as an optimal control problem on a hybrid system. We show that solving the hybrid pursuit game is equivalent to finding a Stackelberg equilibrium solution for a partial information Markov game, which can be solved using dynamic programming. Since for most realistic situations this approach is computationally very difficult, we propose a two-level suboptimal solution that uses a greedy control for coordinating the agents within each team, and a threshold-based logic for orchestrating the switching between teams. Simulations are included to show the feasibility of the approach.
Outdoor Recreation Careers: A Need for Socially Sensitive People and Training in the Social Sciences (1992)

Abstract Professionals trained in natural resources currently represent the majority of people responsible for managing outdoor recreation on wildland areas throughout the United States. However, these professionals are known to be academically and psychologically ill prepared to deal effectively with people and the problems that ensue. In this article, the author describes why managers are not well qualified for recreational management, suggests seeking people having a social orientation, and proposes training people in the social, political, and communication sciences for careers in recreation management.
The Prognostic Role of Circulating Tumor Cells (CTCs) in Lung Cancer (2018)

Lung cancer affects over 1. 8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include "liquid biopsies" through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting.
Optical Fiber Sensor for Corrosion Detection and Evolution Monitoring in Reinforced Concrete Structures (2013)

Conference of 9th International Workshop on Structural Health Monitoring: A Roadmap to Intelligent Structures, IWSHM 2013 ; Conference Date: 10 September 2013 Through 12 September 2013; Conference Code:114374
Bio-expert : Knowledge Management Platform and Experiment for Bio-Medical e-Learning (2002)

Colloque avec actes et comité de lecture. internationale.
The rus-1 mutation suppresses cytological defects in recBC sbcBC ruv mutants of Escherichia coli (2002)

Background and Purpose: The RuvABC proteins of Eschenchia coli play an important role in the processing of Holliday junctions dunng homologous genetic recombination. We have previously found that a ruvC mutation drastically reduces cell viability and causes severe defects in chromosome segregation and cell division when introduced into the recBC sbcBC strain of E. coli. The aim of this work was to further study the mechanisms leading to morphological defects and reduced viability in recBC sbcBC ruv mutants. For this purpose, we have examined the effects of elevated rusA gene expression on cytological patterns of these mutants (the rusA gene codes for a resolvase that can substitute for RuvABC complex in the process of Holliday junction resolution). Material and Methods: Different E. coli recBC sbcBC derivatives were constructed by Pl transduction. Cell growth was monitored by measuring the optical density at 600 nm. Cells were fixed with OsO 4 and their chromosomes were visualized by staining with DAPI. Cell morphology was examined by combined phase-contrast and fluorescence microscopy. Results: The ruvA, ruvB and ruvC mutations cause chromosome segregation and cell division defects, and reduce cell viability when introduced into a recBC sbcBC background. All ruv-associated cytological defects could be suppressed by the rus-1 mutation which is known to induce synthesis of an alternative Holliday junction resolvase, the RusA protein. The suppression by rus-1 is the most efficient in recBC sbcBC strains carrying a ruvAmutation. The suppressive effect of rus-1 depends critically on a functional recG gene. Conclusion: Our results suggest that in recBC sbcBC ruv mutants abortive recombination takes place during exponential growth. The unresolved Holliday junctions accumulated during this process cause cytological defects and affect cell viability.
New conformation exhibiting near-threefold symmetry for uncomplexes valinomycin in crystals from dimethyl sulfoxide (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew conformation exhibiting near-threefold symmetry for uncomplexes valinomycin in crystals from dimethyl sulfoxideIsabella L. Karle and Judith L. Flippen-AndersonCite this: J. Am. Chem. Soc. 1988, 110, 10, 3253–3257Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/ja00218a040https://doi.org/10.1021/ja00218a040research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Chirped Fiber-Optic Bragg Grating Interrogator in a Multiplexed Bragg Grating Sensor Configuration (2004)

This paper presents a chirped grating interrogator for fiber Bragg grating sensors. The interrogator uses the wavelength dependence of the phase group-delay response of a chirped fiber Bragg grating to determine the Bragg wavelength of the sensor. The sensitivity of the interrogator is determined by the selection of the grating length and the bandwidth. The experimental results demonstrated strain measurements over a range of more than 10 000 /spl mu/m per meter. Multiplexing can be achieved by using an arrayed-waveguide grating that allows the interrogation of more than one grating sensor with a single chirped grating.
Surface reconstruction formed by ordered missing molecular rows observedon the quasi-one-dimensional organic conductor Β-(BEDT-TTF<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mo>)</mml:mo></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">PF</mml:mi></mml:mrow><mml:mrow><mml:mn>6</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>s (1997)

The surface structure of a quasi-one-dimensional organic conductor \ensuremath{\mathrm{B}}-(BEDT-TTF${)}_{2}$ ${\mathrm{PF}}_{6}$ crystal [BEDT-TTF is bis(ethylenedithio)-tetrathiafulvalene] was studied by scanning tunneling microscopy (STM). Twofold periodic modulation along the crystal a axis was observed on the crystal a-c plane with a ${\mathrm{PF}}_{6}$ top layer, similarly as the previous result obtained for the surface with a BEDT-TTF top layer. With the analysis using high-resolution STM images including the second BEDT-TTF molecular layer, the surface superstructure was found to be formed by alternate missing rows of ${\mathrm{PF}}_{6}$ molecules. To our knowledge, this is the first observation of an organic surface reconstruction involving such a drastic change in the molecular arrangement, which was comprehensively explained using a proposed model based on the charge balance in the surface layers.
Determination of basic magnetic unit size in CoCrTa/Cr magnetic disk media (1998)

The magnetic transition region in a CoCrTa/Cr hard disk has been studied with high-resolution Foucault-mode Lorentz microscopy. It was found that the amplitude of the zigzag transition increases significantly at the track edges. Imaging results show that the CoCrTa grains behave magnetically in a clustered manner, forming domains of varying sizes at the transition. The dimension of the smallest grain cluster [or the basic magnetic unit (bmu)] has been determined by studying a pair of antiparallel domain contrast images in this medium, Investigations also reveal that each bmu consists of six to eight CoCrTa hcp grains, giving an average bmu unit size of about 80/spl plusmn/12 mm. Furthermore, the magnetic domain images indicate that the mechanical texture induced by polishing does not break up this intergranular coupling.
MRI of diffuse liver disease: characteristics of acute and chronic diseases (2014)

Diffuse liver disease, including chronic liver disease, affects tens of millions of people worldwide, and there is a growing need for diagnostic evaluation as treatments become more readily available, particularly for viral liver diseases. Magnetic resonance imaging (MRI) provides unique capabilities for noninvasive characterization of the liver tissue that rival or surpass the diagnostic utility of liver biopsies. There has been incremental improvement in the use of standardized MRI sequences, acquired before and after administration of a contrast agent, for the evaluation of diffuse liver disease and the study of the liver parenchyma and blood supply. More recent developments have led to methods for quantifying important liver metabolites, including lipids and iron, and liver fibrosis, the hallmark of chronic liver disease. Here, we review the MRI techniques and diagnostic features associated with acute and chronic liver disease.
Conservation biology of the rare species Conospermum undulatum and Macarthuria keigheryi in an urban bushland remnant (2006)

We evaluated the utility of a focussed, short-duration research program for investigation of two rare species that occur within an urban bushland remnant, with application for improving conservation management and translocation outcomes. Conospermum undulatum Lindl. is listed as Threatened and Macarthuria keigheryi Lepschi is listed as Vulnerable under the (Australian) Federal Environment Protection and Biodiversity Conservation Act 1999. The C. undulatum population lacked evidence of juvenile plants, indicating either lack of a suitable germination cue or failure of seedling establishment. The M. keigheryi population was browsed heavily by feral rabbits where exposed and thrived when sheltered within unpalatable vegetation from rabbits. Seeds of M. keigheryi were rapidly removed in an ant cafeteria-style experiment, although seeds of the related Macarthuria australis and an ‘outgroup’ species, Gompholobium tomentosum, were removed at equally high rates. Seed viability was high in M. keigheryi, but variable in C. undulatum. Germination rates, in untreated fresh seed, were 11% for C. undulatum and 0% for M. keigheryi and increased to 27 and 3%, respectively, when treated with gibberellic acid. Maximum strike rates for cuttings of 33 and ~75% were obtained for C. undulatum and M. keigheryi, respectively. Cutting-grown plants of M. keigheryi flowered and seeded profusely in the nursery within 7 months, providing a highly effective seed-orchard resource for research and conservation seed banking. Genetic fingerprinting (AFLP) indicated that the C. undulatum population at Perth Airport was not genetically distinct from nearby C. undulatum populations, despite its relatively high variability in leaf morphology. All C. undulatum populations contained moderate to high levels of genetic variation, with the percentage of AFLP markers polymorphic ranging from 48.6 to 64.9%, and heterozygosity from 0.167 to 0.202. Overall, the knowledge gained from this program of short duration will enable informed management and will underpin successful population enhancement through future translocations.
Array-Based Analysis on Tobacco Plastid Transcripts: Preparation of a Genomic Microarray Containing All Genes and All Intergenic Regions (2003)

The plastid genome of higher plants includes about 120 genes. We adopted genomic array technologies to the tobacco plastid genome. A microarray was constructed, consisting of 220 DNA fragments that cover the whole genome sequence. Each DNA fragment corresponds to a single known gene or an intergenic region. We evaluated reliability of this microarray by comparing the plastid RNA level in light- or dark-grown tobacco seedlings. The transcripts encoding photosynthetic subunits increased significantly in light-grown tissues as expected. Furthermore, we found unexpected signals in several intergenic regions, suggesting the existence of novel transcripts in tobacco plastids.
[Effect of natural porcine surfactant (Curosurf) on the function of neutrophilic granulocytes]. (1990)

In this study we have analyzed various phagocytic functions of human neutrophils exposed to either biochemically well defined porcine surfactant (Curosurf) or a phospholipid preparation. Adherence, random migration and chemotactic response to zymosan activated serum and formyl-methionyl-leucyl-phenylalanine were normal in surfactant treated neutrophils; surfactant was not a chemotactic stimulus. In contrast, phagocytosis of S. aureus by neutrophils exposed to surfactant (100 micrograms/ml) or phospholipids (100 micrograms/ml) was impaired (surfactant: t30 49.5 +/- 9.0%, t60 65.0 +/- 8.0%; phospholipids: t30 66.3 +/- 12.6%, t60 78.0 +/- 7.8%; controls: t30 78.1 +/- 8.9%, t60 90.1 +/- 6.2%; p less than 0.001 at t30, t60 for surfactant, p less than 0.05 at t60 for phospholipids). Due to the smaller number of S. aureus ingested, bactericidal activity of surfactant or phospholipid treated neutrophils was slightly reduced when compared to controls (surfactant t30 p less than 0.05, surfactant t60 p less than 0.001, phospholipids t60 p less than 0.05). Surfactant or phospholipids had no bactericidal activity. Uptake of candida was identical in surfactant or phospholipid treated neutrophils with untreated controls; the same was true with the number of candida per cell ingested. Phagocytosis-associated chemiluminescence and production of superoxide anion by neutrophils of either source in response to phorbol myristate acetate and opsonized zymosan was also identical.
Diagnosis and Management of Oropharyngeal Dysphagia and Its Nutritional and Respiratory Complications in the Elderly (2010)

Oropharyngeal dysphagia is a major complaint among older people. Dysphagia may cause two types of complications in these patients: (a) a decrease in the efficacy of deglutition leading to malnutrition and dehydration, (b) a decrease in deglutition safety, leading to tracheobronchial aspiration which results in aspiration pneumonia and can lead to death. Clinical screening methods should be used to identify older people with oropharyngeal dysphagia and to identify those patients who are at risk of aspiration. Videofluoroscopy (VFS) is the gold standard to study the oral and pharyngeal mechanisms of dysphagia in older patients. Up to 30% of older patients with dysphagia present aspiration-half of them without cough, and 45%, oropharyngeal residue; and 55% older patients with dysphagia are at risk of malnutrition. Treatment with dietetic changes in bolus volume and viscosity, as well as rehabilitation procedures can improve deglutition and prevent nutritional and respiratory complications in older patients. Diagnosis and management of oropharyngeal dysphagia need a multidisciplinary approach.