gebhart/patrepeval huggingface dataset:
Optimal path planning in a constant wind with a bounded turning rate (2005)

In this paper, we explore the problem of generating the optimal time path from an initial position and orientation to a flnal position and orientation in the two-dimensional plane for an aircraft with a bounded turning radius in the presence of a constant wind. Following the work of Boissonnat, we show using the Minimum Principle that the optimal path consists of periods of maximum turn rate or straight lines. We demonstrate, however, that unlike the no wind case, the optimal path can consist of three arcs where the length of the second arc is less than …. A method for generating the optimal path is also presented which iteratively solves the no wind case to intercept a moving virtual target. I. Introduction Optimal path planning is an important problem for robotics and unmanned vehicles. In this paper, we explore a method for flnding the shortest path from an initial position and orientation to a flnal position and and orientation in the two-dimensional plane for an aircraft with a bounded turning radius in the presence of a constant wind. This work was motivated by our group’s work with our ∞eet of small autonomous aircraft. Each modifled Sig Rascal aircraft ∞ies under the combined control of an ofi-the-shelf Piccolo avionics package for low level control and an onboard PC104 computer for higher level tasks. These aircraft ∞y at a nominal speed of 20 m/s, and wind speeds of over 5 m/s have been encountered during ∞ight testing. The problem described above was flrst solved in the case of no wind by Dubins using geometric arguments 8
Distribution of ELOVL4 in the Developing and Adult Mouse Brain (2017)

ELOngation of Very Long chain fatty acids (ELOVL)-4 is essential for the synthesis of very long chain-fatty acids (fatty acids with chain lengths ≥ 28 carbons). The functions of ELOVL4 and its very long-chain fatty acid products are poorly understood at present. However, mutations in <i>ELOVL4</i> cause neurodevelopmental or neurodegenerative diseases that vary according to the mutation and inheritance pattern. Heterozygous inheritance of different <i>ELOVL4</i> mutations causes Stargardt-like Macular Dystrophy or Spinocerebellar Ataxia type 34. Homozygous inheritance of <i>ELOVL4</i> mutations causes more severe disease characterized by seizures, intellectual disability, ichthyosis, and premature death. To better understand ELOVL4 and very long chain fatty acid function in the brain, we examined ELOVL4 expression in the mouse brain between embryonic day 18 and postnatal day 60 by immunolabeling using ELOVL4 and other marker antibodies. ELOVL4 was widely expressed in a region- and cell type-specific manner, and was restricted to cell bodies, consistent with its known localization to endoplasmic reticulum. ELOVL4 labeling was most prominent in gray matter, although labeling also was present in some cells located in white matter. ELOVL4 was widely expressed in the developing brain by embryonic day 18 and was especially pronounced in regions underlying the lateral ventricles and other neurogenic regions. The basal ganglia in particular showed intense ELOVL4 labeling at this stage. In the postnatal brain, cerebral cortex, hippocampus, cerebellum, thalamus, hypothalamus, midbrain, pons, and medulla all showed prominent ELOVL4 labeling, although ELOVL4 distribution was not uniform across all cells or subnuclei within these regions. In contrast, the basal ganglia showed little ELOVL4 labeling in the postnatal brain. Double labeling studies showed that ELOVL4 was primarily expressed by neurons, although presumptive oligodendrocytes located in white matter tracts also showed labeling. Little or no ELOVL4 labeling was present in astrocytes or radial glial cells. These findings suggest that ELOVL4 and its very long chain fatty acid products are important in many parts of the brain and that they are particularly associated with neuronal function. Specific roles for ELOVL4 and its products in oligodendrocytes and myelin and in cellular proliferation, especially during development, are possible.
Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70 (2001)

Triggering of the T cell antigen receptor (TCR).CD3 complex induces its ubiquitination. However, the molecular events that lead to ubiquitin conjugation to these cell surface molecules have not been defined. Here we report that Cbl, a RING-type E3 ubiquitin-protein ligase, promotes ubiquitination of TCR zeta chain, which requires its functional variant Src homology 2 domain and an intact RING finger. The tyrosine kinase Zap-70, which binds to both TCR zeta and Cbl, plays an adaptor role in these events. Mutations in TCR zeta, Zap-70, or Cbl that disrupt the interaction between TCR zeta and Zap-70 or between Zap-70 and Cbl reduce ubiquitination of TCR zeta. Our results suggest a novel mechanism by which Cbl negatively regulates T cell development and activation by inducing ubiquitination of the TCR.CD3 components.
Surface Flaw Detection Using Oblique Angle Illumination (1972)

An analysis of a surface flaw detection method is presented in which oblique illumination is combined with a high pass spatial filter to detect the light scattered from surface flaws. The effects of surface finishes of test samples (meteoric plates) are assessed statistically, and the sensitivity of the system is calculated. Data have been collected on diffraction patterns and surface scratch detection for three stainless steel plates having different surface finishes. The results agree with theoretical considerations and are quite promising.
Investigations on the use of breath gas analysis with Proton Transfer Reaction Mass Spectrometry (PTR-MS) for a non-invasive method of early lung cancer detection (2009)

The analysis of volatile organic compounds (VOCs) in exhaled air is an inexpensive and non-invasive method for early detection and diagnosis of human disease. This biophysical methodology in the context of a clinical study based on whether certain lung diseases (including cancer) can be identified early using proton-transfer mass spectrometry (PTR-MS) has been tested. For different groups, such as lung cancer patients, patients with other lung diseases and healthy controls in different environments and lifestyles (e.g. smoking) the measured exhaled VOCs found a significant effect of lung disease on the measured signals.
Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18 (1990)

The E6-E7 region of human papillomavirus types 16 and 18 is selectively retained and expressed in cervical carcinoma cells. In cultured human keratinocytes, expression of the E6 and E7 open reading frames of human papillomavirus type 18, under the control of its homologous promoter, resulted in high-frequency immortalization. Furthermore, by using a system that allows for stratification of keratinocytes in vitro (raft system), we observed that the morphological differentiation of these E6-E7 immortalized cells was altered such that parabasal cells extended throughout most of the epithelium, with abnormal nuclei present in the upper regions. Examination of E6-E7-expressing cell lines in the raft system at a later passage revealed that complete loss of morphological differentiation had occurred. E7 alone was a much less effective immortalizing agent than E6 and E7 together and acted only minimally to alter morphological differentiation in vitro. No such activities were found for E6 alone. High-frequency transformation of human epithelial cells thus appears to require expression of both E6 and E7 gene products.
Migraine Prevalence: A Literature Review (1998)

Worldwide epidemiological studies provide estimates of migraine prevalence. The International Headache Society (IHS) diagnostic criteria have permitted more reliable and generalizable study estimates. In this review, recent population-based reports of IHS-defined migraine are discussed to update the current epidemiological literature, to highlight methodological challenges, and to encourage greater public awareness of this frequently undiagnosed disabling disorder.
Renal Artery Stenosis Evaluation in Chronic Kidney Disease Patients: Nonenhanced Time-Spatial Labeling Inversion-Pulse Three-dimensional MR Angiography with Regulated Breathing versus DSA (2011)

http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101422/-/DC1.
Chemical Protection of Bacteria and Cultured Mammalian Cells by Sulfur-Containing Compounds (1975)

Protection by sulfur-containing compounds was studied with use of bacteria E. coli BH and cultured mouse leukemic cells, L 5178 Y, and the protective mechanisms were discussed. The dose reduction factors of non-sulfhydryl compounds observed in the bacteria were the same as those observed in the mammalian cells, and the protective activity of these compounds was proportional to their reaction rates with hydroxyl radicals. On the other hand, sulfhydryl compounds except glutathione, offered much greater protection than the protection which was anticipated from their radical scavenging activiy. From studies under anoxia, the protection of cysteine was explained by its OH scavenging and competition with oxygen. For MEA, protection against the direct action of radiation was suggested, in addition. This was supporrted by the significant protection in the frozen state.
Rotating robots move collectively and self-organize (2018)

Biological organisms and artificial active particles self-organize into swarms and patterns. Open questions concern the design of emergent phenomena by choosing appropriate forms of activity and particle interactions. A particularly simple and versatile system are 3D-printed robots on a vibrating table that can perform self-propelled and self-spinning motion. Here we study a mixture of minimalistic clockwise and counter-clockwise rotating robots, called rotors. Our experiments show that rotors move collectively and exhibit super-diffusive interfacial motion and phase separate via spinodal decomposition. On long time scales, confinement favors symmetric demixing patterns. By mapping rotor motion on a Langevin equation with a constant driving torque and by comparison with computer simulations, we demonstrate that our macroscopic system is a form of active soft matter.
Clinical Diagnostic Accuracy of Otitis Media with Effusion in Children, and Significance of Myringotomy: Diagnostic or Therapeutic? (2004)

The specific aims of this prospective survey were to determine the accuracy of traditional diagnostic tools, such as pneumatic otoscopy, otomicroscopy, and tympanometry, and evaluate the usefulness of myringotomy as a diagnostic method; also to determine the significance of myringotomy in treating otitis media with effusion (OME). The status of middle ear of 51 children (85 ears) from November 2002 to February 2003 was examined using pneumatic otoscopy, otomicroscopy, and tympanometry, and the presence/absence of middle ear effusion was confirmed by myringotomy. The otomicroscopy was the most sensitive and specific one among three diagnostic tools. But, it had some false positive cases. This study failed to show the therapeutic efficacy of myringotomy. Otomicroscopy seems to have the potential to become the standard for diagnosis of OME and for validation of pneumatic otoscopy in children. However, when otoscopic, otomicroscopic findings and tympanogram of suspected ear show poor correlation, myringotomy can be used to confirm the presence of OME, as the diagnostic modality. As the therapeutic modality, we think that it is proper to limit indications of myringotomy to some selected cases.
A real world implementation of answer extraction (2002)

We describe ExtrAns, an answer extraction system. Answer extraction (AE) aims at retrieving those exact passages of a document that directly answer a given user question. AE is more ambitious than information retrieval and information extraction in that the retrieval results are phrases, not entire documents, and in that the queries may be arbitrarily specific. It is less ambitious than full-fledged question answering in that the answers are not generated from a knowledge base but looked up in the text of documents. The current version of ExtrAns is able to parse unedited Unix "man pages", and derive the logical form of their sentences. User queries are also translated into logical forms. A theorem prover then retrieves the relevant phrases, which are presented through selective highlighting in their context.
Imaging dielectric objects from scalar intensity patterns by means of indirect holography (2005)

An indirect microwave holographic technique for the reconstruction of complex scattered fields and the imaging of objects from a single holographic intensity pattern is described. The holographic intensity pattern is constructed by combining the signal scattered from the dielectric object with a synthesised reference signal. This dispenses with the need for expensive phase measuring equipment. Reconstructed magnitude and phase patterns of the original object have been determined using an adaptation of optical techniques. This work describes how dielectric objects of low contrast to the background when viewed using reconstructed magnitude patterns can be imaged from reconstructed phase patterns.
Systemic Inflammatory Response Syndrome After Acute Myocardial Infarction Complicated by Cardiogenic Shock (2005)

Almost one fifth of patients with acute myocardial infarction complicated by CS showed clinical signs of severe systemic inflammation, and those who were culture-positive for sepsis had twice the risk of death. The observation of lower SVR at the onset of shock in patients who subsequently had culture-positive systemic inflammation suggests that inappropriate vasodilation may play an important role in the pathogenesis and persistence of shock and in the risk of infection.
A comparative study on inter and intralaboratory reproducibility of renin measurement with a conventional enzymatic method and a new chemiluminescent assay of immunoreactive renin (2010)

The measurement of renin with the chemiluminescent method is a reliable alternative to PRA, having the advantage of a superior inter and intralaboratory reproducibility.
Resistance to vancomycin and teicoplanin: an emerging clinical problem (1990)

Vancomycin and teicoplanin are glycopeptides active against a wide range of gram-positive bacteria. For 30 years following the discovery of vancomycin in 1956, vancomycin resistance was not detected among normally susceptible bacteria recovered from human specimens. Since 1986, however, bacteria resistant to vancomycin or teicoplanin or both have been described. Strains of the genera Leuconostoc, Lactobacillus, Pediococcus, and Erysipelothrix seem inherently resistant to glycopeptides. Species and strains of enterococci and coagulase-negative staphylococci appear to have acquired or developed resistance. There are at least two categories of glycopeptide resistance among enterococci, characterized by either high-level resistance to vancomycin (MIC, greater than or equal to 64 mg/liter) and teicoplanin (MIC, greater than or equal to 8 mg/liter) or lower-level vancomycin resistance (MIC, 32 to 64 mg/liter) and teicoplanin susceptibility (MIC, less than or equal to 1 mg/liter). The two categories appear to have similar resistance mechanisms, although genetic and biochemical studies indicate that they have arisen independently. Among coagulase-negative staphylococci, strains for which vancomycin MICs are up to 20 mg/liter or teicoplanin MICs are 16 to 32 mg/liter have been reported, but cross-resistance between these glycopeptides varies. The selective advantage accorded to glycopeptide-resistant bacteria and the observation that high-level resistance in enterococci is transferable suggest that such resistance may be expected to increase in incidence. Clinicians and microbiologists need to be aware of this emerging problem.
Issues in Hypertriglyceridemic Pancreatitis (2013)

Hypertriglyceridemia (HTG) is a well-established but underestimated cause of acute pancreatitis and recurrent acute pancreatitis. The clinical presentation of HTG-induced pancreatitis (HTG pancreatitis) is similar to other causes. Pancreatitis secondary to HTG is typically seen in the presence of one or more secondary factors (uncontrolled diabetes, alcoholism, medications, pregnancy) in a patient with an underlying common genetic abnormality of lipoprotein metabolism (familial combined hyperlipidemia or familial HTG). Less commonly, a patient with rare genetic abnormality (familial chylomicronemic syndrome) with or without an additional secondary factor is encountered. The risk of acute pancreatitis in patients with serum triglycerides >1000 and >2000 mg/dL is ∼5% and 10% to 20%, respectively. It is not clear whether HTG pancreatitis is more severe than when it is due to other causes. Clinical management of HTG pancreatitis is similar to that of other causes. Insulin infusion in diabetic patients with HTG can rapidly reduce triglyceride (TG) levels. Use of apheresis is still experimental and better designed studies are needed to clarify its role in the management of HTG pancreatitis. Diet, lifestyle changes, and control of secondary factors are key to the treatment, and medications are useful adjuncts to the long-term management of TG levels. Control of TG levels to 500 mg/dL or less can effectively prevent recurrences of pancreatitis.
Impaired endothelium-mediated vasodilation is not the principal cause of vasoconstriction in heart failure (2000)

The extent to which abnormal endothelium-dependent vasodilator mechanisms contribute to abnormal resting vasoconstriction and blunted reflex vasodilation seen in heart failure is unknown. The purpose of this study was to test the hypothesis that the resting and reflex abnormalities in vascular tone that characterize heart failure are mediated by abnormal endothelium-mediated mechanisms. Thirteen advanced heart-failure patients (New York Heart Association III-IV) and 13 age-matched normal controls were studied. Saline, acetylcholine (20 microg/min), or L-arginine (10 mg/min) was infused into the brachial artery, and forearm blood flow was measured by venous plethysmography at rest and during mental stress. At rest, acetylcholine decreased forearm vascular resistance in normal subjects, but this response was blunted in heart failure. During mental stress with intra-arterial acetylcholine or L-arginine, the decrease in forearm vascular resistance was not greater than during saline control in heart failure [saline control vs. acetylcholine (7 +/- 3 vs. 6 +/- 3, P = NS) or vs. L-arginine (9 +/- 2 units, P = NS)]. The increase in forearm blood flow was not greater than during saline control in heart failure [saline control vs. acetylcholine (1. 2 +/- 0.3 vs. 1.3 +/- 0.3, P = NS), or vs. L-arginine (1.2 +/- 0.2 ml x min(-1) x 100 ml(-1), P = NS)]. Furthermore, during mental stress with nitroprusside, the decrease in forearm vascular resistance was not greater than during saline control [saline control vs. nitroprusside (7 +/- 3 vs. 5 +/- 4 ml x min(-1) x 100 g(-1), P = NS)], and the increase in forearm blood flow was not greater than during saline control [saline control vs. nitroprusside (1.2 +/- 0.3 vs. 1.3 +/- 0.5 ml x min(-1) x 100 g(-1), P = NS)]. Because the endothelial-independent agent nitroprusside was unable to restore resting and reflex vasodilation to normal in heart failure, we conclude that impaired endothelium-mediated vasodilation with acetylholine-nitric oxide cannot be the principal cause of the attenuated resting- or reflex-mediated vasodilation in heart failure.
Structure and interactions of ether- and ester-linked phosphatidylethanolamines (1991)

The ether-linked phospholipid 1,2-dihexadecylphosphatidylethanolamine (DHPE) was studied as a function of hydration and in fully hydrated mixed phospholipid systems with its ester-linked analogue 1,2-dipalmitoylphosphatidylethanolamine (DPPE). A combination of differential scanning calorimetry (DSC) and X-ray diffraction was used to examine the phase behavior of these lipids. By DSC, from 0 to 10 wt % H2O, DHPE displayed a single reversible transition that decreased from 95.2 to 78.8 degrees C and which was shown by X-ray diffraction data to be a direct bilayer gel to inverted hexagonal conversion, L beta----HII. Above 15% H2O, two reversible transitions were observed which stabilized at 67.1 and 92.3 degrees C above 19% H2O. X-ray diffraction data of fully hydrated DHPE confirmed the lower temperature transition to be a bilayer gel to bilayer liquid-crystalline (L beta----L alpha) phase transition and the higher temperature transition to be a bilayer liquid-crystalline to inverted hexagonal (L alpha----HII) phase transition. The lamellar repeat distance of gel-state DHPE increased as a function of hydration to a limiting value of 62.5 A at 19% H2O (8.6 mol of water/mol of DHPE), which corresponds to the hydration at which the transition temperatures are seen to stabilize by DSC. Electron density profiles of DHPE, in addition to calculations of the lipid layer thickness, confirmed that DHPE in the gel state forms a noninterdigitated bilayer at all hydrations. Fully hydrated mixed phospholipid systems of DHPE and DPPE exhibited two reversible transitions by DSC.(ABSTRACT TRUNCATED AT 250 WORDS)
<title>Pose determination of cylinders, cones, and spheres from perspective projections</title> (1992)

This paper addresses the computation of spheres, right-circular cylinders, and right-circular cones from a single view. Geometric information about these objects are known a priori, as this would be the case for model-based vision applications. The 3-D poses of these objects can be computed using elliptical projection from the sphere or elliptical projections from the circular surfaces of a cylinder or cone. For the cylinder and cone, their poses can also be computed form their linear extremal contours. This paper employs simple analytic geometric techniques that address uniqueness of the solutions as well as the geometric interpretations of the non-unique solutions. For the sphere, its pose can be uniquely determined by its elliptical projection. Using a planar circular surface from either the cone or the cylinder, two solutions to the position and orientation of the circle are possible. From the linear extremal contours of a cylinder, its pose can be computed uniquely if the junctions are visible in the image, otherwise the position has one degree of freedom along the cylinder axis. From the linear contours of a cone, its pose can also be solved uniquely unless the junctions are occluded. In that case there are two possible solutions for the orientation but the position has one degree of freedom along the line joining the projection center to the image apex position.
The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function <i>In Vivo</i> and Induces Insulin Resistance (2005)

The function of the pancreatic beta-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17beta-estradiol (E2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 microg/kg) of either E2 or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma insulin. Longer exposures to E2 and BPA induce an increase in pancreatic beta-cell insulin content in an estrogen-receptor-dependent manner. This effect is visible after 2 days of treatment and starting at doses as low as 10 microg/kg/day. After 4 days of treatment with either E2 or BPA, these mice developed chronic hyperinsulinemia, and their glucose and insulin tolerance tests were altered. These experiments unveil the link between environmental estrogens and insulin resistance. Therefore, either abnormal levels of endogenous estrogens or environmental estrogen exposure enhances the risk of developing type 2 diabetes mellitus, hypertension, and dyslipidemia.