gebhart/patrepeval huggingface dataset:
ADCC Enhancement Technologies for Next‐Generation Therapeutic Antibodies (2016)

Antibody-dependent cellular cytotoxicity (ADCC) enhancement is a key strategy for improving therapeutic antibody-drug efficacy. Recombinant therapeutic antibodies represent a successful new class of drugs developed over the past two decades. Human IgG1 bears two N-linked biantennary complex-type oligosaccharides covalently attached at the conserved asparagine 297 (Asn297), which is in the CH2 domain of the Fc region. Potelligent technology, belonging to Kyowa Hakko Kirin company, and later licensed to Lonza, was employed to develop the FUT8 knockout CHO cell line by gene targeting using a homologous recombination technique. The GlymaxX technology for production of afucosylated antibodies was developed by ProBioGen AG, a Germany-based biotech company. Using modified sugars that inhibit the incorporation of fucose into the oligosaccharide chains of monoclonal antibodies (mAbs), SEA technology, developed by Seattle Genetics, generates defucosylated mAbs with enhanced ADCC activity. Several ADCC enhancement technology platforms were developed using yeast strains.
Phytonutrient deficiency: the place of palm fruit. (2003)

The oil palm (Elaeis guineensis) is native to many West African countries, where local populations have used its oil for culinary and other purposes. Large-scale plantations, established principally in tropical regions (Asia, Africa and Latin America), are mostly aimed at the production of oil, which is extracted from the fleshy mesocarp of the palm fruit, and endosperm or kernel oil. Palm oil is different from other plant and animal oils in that it contains 50% saturated fatty acids, 40% unsaturated fatty acids, and 10% polyunsaturated fatty acids. The fruit also contains components that can endow the oil with nutritional and health beneficial properties. These phytonutrients include carotenoids (alpha-,beta-,and gamma-carotenes), vitamin E (tocopherols and tocotrienols), sterols (sitosterol, stigmasterol and campesterol), phospholipids, glycolipids and squalene. In addition, it is recently reported that certain water-soluble powerful antioxidants, phenolic acids and flavonoids, can be recovered from palm oil mill effluent. Owing to its high content of phytonutrients with antioxidant properties, the possibility exists that palm fruit offers some health advantages by reducing lipid oxidation, oxidative stress and free radical damage. Accordingly, use of palm fruit or its phytonutrient-rich fractions, particularly water-soluble antioxidants, may confer some protection against a number of disorders or diseases including cardiovascular disease, cancers, cataracts and macular degeneration, cognitive impairment and Alzheimer's disease. However, whilst prevention of disease through use of these phytonutrients as in either food ingredients or nutraceuticals may be a worthwhile objective, dose response data are required to evaluate their pharmacologic and toxicologic effects. In addition, one area of concern about use of antioxidant phytonutrients is how much suppression of oxidation may be compatible with good health, as toxic free radicals are required for defence mechanisms. These food-health concepts would probably spur the large-scale oil palm (and monoculture) plantations, which are already seen to be a major cause of deforestation and replacement of diverse ecosystems in many countries. However, the environmental advantages of palm phytonutrients are that they are prepared from the readily available raw material from palm oil milling processes. Palm fruit, one of only a few fatty fruits, is likely to have an increasingly substantiated place in human health, not only through the provision of acceptable dietary fats, but also its characteristic protective phytonutrients.
Integrating GNSS, IMU, and Imagery for Automatic Orthomosaic Generation (2009)

The use of orthomosaic images from aerial or satellite data\nare increasingly common. While current acquisition methods\nare cost-effective on a national or regional scale, local\nscale imagery is prohibitively expensive for many target applications. In this paper we present a combined hardware\nand software solution, developed at the Geospatial Research\nCentre, which aims to reduce the cost of acquiring\nand processing imagery and related data in order to produce\northomosaics in a cost-effective manner on a small,\nlocal scale.\nThe hardware component consists of a combined GNSS\nand inertial solution for determining the position and orientation\nof a sensor, typically a consumer-grade camera such\nas a digital SLR. The combination of imagery and navigation\nmetadata allows images to be directly geo-referenced\nby projecting them on to readily available surface models.\nRefinements to this initial processing are also presented,\nwhich account for boresight and lens calibration error; automatically\nestablishing a correspondence between image\nfeatures for bundle adjustment; and reducing the visual appearance\nof any residual misalignments in the final mosaic.\nThe use of commodity sensors and automated processing is\nan important step in reducing the cost of image acquisition\nand orthomosaic generation.\nThe methods described are illustrated using two sample sequences.\nThe first is a set of visible images captured from a\ndigital SLR, and the second a set of frames extracted from a\nthermal video sequence. These two sequences demonstrate\nthe range of imagery that can be processed, which can support\napplications ranging from environmental monitoring\nand precision agriculture to urban planning and infrastructure\nmaintenance.
Mixing pulp suspensions (2010)

Initiation and maintenance of motion within a pulp suspension is necessary for effective mixing. This requires imposition of forces greater than the network strength and depends on suspension rheology once motion begins. As pulp suspensions display non-Newtonian and solid-like behaviour, studies were conducted using profiled rotors which imposed stress within the body of suspensions contained in cylindrical devices. A concentric cylinder device capable of high torques (85 N-m) and high rotational speeds (524 rad/s) was built to study pulp suspension dynamic behaviour. Most work used a profiled rotor 0.1 m in diameter with baffled housings 0.13 and 0.22 m in diamter. The yield stress of low consistency pulp suspensions were measured with a Haake RV12 Ro-tovisco concentric cylinder viscometer. Semi-bleached kraft pulp was used throughout the study. Some tests were made with stone groundwood and thermomechanical pulps. Yield stress measurements were made for nylon and Spectra-900 fibre suspensions. The yield stress of pulp suspensions, ty, have been measured and correlated with mass concentration (Cm) and volumetric concentration (Cv) over the range 0.4 ≤ Cm(%) ≤ 33. It was found that because of increasing gas content that correlations developed using the mass concentration were inaccurate above approximately 20% Cm. Correlations developed using the volumetric concentration were accurate over the full range tested. For a West-Coast semi-bleached kraft pulp, ty(Pa) = 1.40CV(%)²ֹ⁷². Once rotor motion was initiated, pulp suspensions exhibited two distinct regimes of behaviour. The first was a tangential-cavity regime in which predominantly tangential motion grew to fill the chamber as shear rate increased. When motion reached the outer housing wall a flow transition occurred, likely triggered by flow interaction with the housing baffles. The subsequent post-transition regime was characterized by radial and axial flow that effectively mixed the suspension on both the macroscale and fibre-scale. The flow transition appeared to be what earlier workers reported as the onset of "fluidization". During tangential-cavity flow, phase segregation occurred. Gas present in the suspension collected around the rotor and reduced momentum transfer from the rotor to the suspension. This caused the torque for the pulp suspension to fall below that for water at the same rotational speed, and the cessation of flow development in the chamber. If sufficient momentum transfer was attained to initiate post-transition flow, the chamber contents became effectively mixed. The torque could still fall below that of water depending on the effective density of the suspension in the rotor vicinity.
Modeling and verifying hybrid dynamic systems using CheckMate (2000)

This article introduces a computational tool called CheckMate. CheckMate is a tool for modelling, prototyping, simulating specific situation and formally verifying hybrid dynamic systems based on the MATLAB/Simulink and Stateflow Toolbox from The MathWorks, Inc. This paper presents the elements of CheckMate from the user’s perspective and illustrates its features using a three dimensional linear system example. The theory underlying CheckMate is also reviewed briefly. More complete presentations of the theory can be found in [1-7].
LAS PRÁCTICAS PREPROFESIONALES COMO HERRAMIENTA DE INSERCIÓN LABORAL PARA INGENIEROS INDUSTRIALES: REALIZACIÓN DE AUDITORÍAS DE SEGURIDAD DE INSTALACIONES (2012)

La inserción laboral es un problema que se repite en todas las profesiones, debiéndose \nprincipalmente a las diferencias entre los contenidos que el alumno recibe durante su formación y \nel desempeño de su primera actividad profesional; los niveles más básicos de formación reglada \n(como los Ciclos Formativos de Grado Medio o Certificados de Cualificación Profesional) incluyen \ncontenidos muy específicos que el alumno aprovechará inmediatamente mientras que aquellas \ntitulaciones más largas tocan aspectos más amplios, de los que la mayoría no serán aprovechados \nen su primer empleo. En el caso de las titulaciones universitarias superiores (y especialmente en el \ncaso de Ingeniería Industrial) los planes de estudios son muy amplios; una vez que el estudiante finaliza la titulación no es especialista en ningún área en particular. Como medida para facilitar la\ninserción laboral se propone la realización de una auditoría de las instalaciones y se expone la \nexperiencia de alumnos de Ingeniería Industrial que han realizado prácticas preprofesionales en la \nUniversidad de Santiago de Compostela (U.S.C.) y en la planta Nissan a lo largo de los últimos \naños.
Blood flow response to cryosurgery on basal cell carcinomas. (1991)

Cryosurgery with liquid nitrogen is commonly used to treat benign and malignant skin tumours. One of the crucial factors which influences the freezing and thawing rate of the target cells is the response of the microcirculation to cold stimulus. In our experiment, laser Doppler flowmetry was used to monitor blood flow during cryosurgical treatment of basal cell carcinomas. Outside the frozen tissue hemisphere, blood flow, as measured by laser Doppler flowmetry, increased almost instantaneously and remained on a high level during thawing. Baseline blood flow at the contralateral anatomical site remained stable. Pharmacological or physical modification of the cutaneous microcirculation before therapy may influence freezing and thawing times, and therefore the outcome with regard to healing, cosmetic appearance and the recurrence rate of basal cell carcinomas.
An Experimental Study on the Capability of Arresting the Spread of a Fire of Fireproof Fabric Equipped over Ceiling Board of Wooden Cultural Properties (2012)

This study examines the isolation-heat performance of fire proof fabric that is equipped over ceiling board in order to secure the capability of arresting the spread of a fire at roof 'Jucsim' structure of Wooden Cultural Properties. For this examination, I conduct experiments with the model and compare two construction methods of fire proof fabric, or flat-type, folding-type. The experiments show the following results. In case of installing the fire proof fabric in flat-type, when the temperature under the ceiling board is , the temperatures over the ceiling board is ; the difference is . Compared with the case of removing fire proof fabric, the temperature over the ceiling board is lower by approximately . Therefore it can be said that the construction of fire proof fabric enhances the isolation-heat performance. In case of installing the fire proof fabric in folding-type, when the temperature under the ceiling board is , the temperatures over the ceiling board is ; the difference is approximately . Thus its isolation-heat performance is a little inferior to the flat-type equipment.
Correlation and Prediction of the Solubility of CO<sub>2</sub> and H<sub>2</sub>S in an Aqueous Solution of 2-Piperidineethanol and Sulfolane (1998)

The simplified Clegg−Pitzer equations are used to correlate the solubility data of CO2 in the 2-PE (2-piperidineethanol) (45 wt %)−TMS (sulfolane) (40 wt %)−H2O (15 wt %) system at 25, 40, 70, 100, and 130 °C and the solubility data of H2S in the 2-PE (45 and 55 wt %)−TMS (40 and 10 wt %)−H2O (15 and 35 wt %) systems at 40 and 100 °C. The interaction parameters thus determined can be used to predict the solubility data for the CO2−2-PE (55 wt %)−TMS (10 wt %)−H2O (35 wt %) system at 40 and 100 °C and also for the quinary CO2−H2S−2-PE−TMS−H2O system without any additional adjustable parameters. The equations have been proven again to be of use for aqueous solutions containing mixed physical and chemical solvents and ionic species with chemical equilibria.
A VLSI architecture design of CAVLC decoder (2003)

Variable length code is an integral component of many international standards on image and video compression. Recently, context-based adaptive variable length coding (CAVLC) is adopted by the emerging JVT (also called H.264 in ITU, and AVC in MPEG-4). In this paper, we describe a novel architecture for CAVLC decoder, including a coeff_token decoder, level decoder, total_zeros decoder and run_before decoder. Together with a barrel shifter and controller, the pipeline architecture can decode every syntax element in one clock cycle. Therefore, it is very suitable for video applications that require high throughput.
Pong: A Flexible Network Services Monitoring System (1994)

In distributed computing environments it is important to determine not only whether individual critical machines are up or down, but also whether the individual services they offer are available. Our site was using a network monitoring package which used ICMP ECHO packets to determine when individual network components were unavailable. We found that there were many occasions where a server would reply to the ICMP ECHO, but would still not be providing the services it should be providing. We needed a tool which would let us monitor high level services such as AFS or NFS file service. This paper will describe a tool called pong which was developed to meet these needs. Pong is a highly configurable monitoring tool which pings individual services at predefined intervals and executes appropriate actions when the state of that service changes. We use pong to monitor three or more services on each of 110 servers.
THE RESPONSIVENESS OF THE ACTION RESEARCH ARM TEST AND THE FUGL-MEYER ASSESSMENT SCALE IN CHRONIC STROKE PATIENTS (2001)

The responsiveness of the Action Research Arm (ARA) test and the upper extremity motor section of the Fugl-Meyer Assessment (FMA) scale were compared in a cohort of 22 chronic stroke patients undergoing intensive forced use treatment aimed at improvement of upper extremity function. The cohort consisted of 13 men and 9 women, median age 58.5 years, median time since stroke 3.6 years. Responsiveness was defined as the sensitivity of an instrument to real change. Two baseline measurements were performed with a 2-week interval before the intervention, and a follow-up measurement after 2 weeks of intensive forced use treatment. The limits of agreement, according to the Bland-Altman method, were computed as a measure of the test-retest reliability. Two different measures of responsiveness were compared: (i) the number of patients who improved more than the upper limit of agreement during the intervention; (ii) the responsiveness ratio. The limits of agreement, designating the interval comprising 95% of the differences between two measurements in a stable individual, were -5.7 to 6.2 and -5.0 to 6.6 for the ARA test and the FMA scale, respectively. The possible sum scores range from 0 to 57 (ARA) and from 0 to 66 (FMA). The number of patients who improved more than the upper limit were 12 (54.5%) and 2 (9.1%); and the responsiveness ratios were 2.03 and 0.41 for the ARA test and the FMA scale, respectively. These results strongly suggest that the ARA test is more responsive to improvement in upper extremity function than the FMA scale in chronic stroke patients undergoing forced use treatment.
What Have Two Decades of British Economic Reform Delivered in Terms of Productivity Growth (2002)

Beginning in 1979 with the newly elected Thatcher Government and continuing under successive Conservative and Labour Governments, the United Kingdom has embarked on a two-decade-long experiment in economic reform. We present evidence that the reform process has succeeded in making the UK more market-friendly than its European competitors. In fact, by the 1990s Britain ranked near the top of the league tables for freedom of markets, in some cases even ahead of the United States. To evaluate the effects of these reforms we compare trends in macroeconomic outcomes in the UK relative to the US, Germany, and France. During the 1980s and 1990s Britain halted the relative declines in GDP per capita and labour productivity that had characterized earlier decades, and partially closed the gap in income per capita with France and Germany. These gains were mainly attributable to relative rises in employment and hours. Unlike its EU competitors, Britain was able to achieve high employmentpopulation rates with rising real wages for workers. The case that the change in economic performance can be credited to market-oriented reforms is harder to prove. Nevertheless, based our own macro-level analyses, and micro-level evidence from several companion studies, we conclude that economic reforms contributed to halting the nearly century-long trend in relative economic decline of the UK relative to its historic competitors, Germany and France.
Nanoscale platforms for messenger RNA delivery (2018)

Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic applications in the past few years. A series of clinical trials are ongoing or will be initiated in the near future for the treatment of a variety of diseases. Currently, mRNA-based therapeutics mainly focuses on ex vivo transfection and local administration in clinical studies. Efficient and safe delivery of therapeutically relevant mRNAs remains one of the major challenges for their broad applications in humans. Thus, effective delivery systems are urgently needed to overcome this limitation. In recent years, numerous nanoscale biomaterials have been constructed for mRNA delivery in order to protect mRNA from extracellular degradation and facilitate endosomal escape after cellular uptake. Nanoscale platforms have expanded the feasibility of mRNA-based therapeutics, and enabled its potential applications to protein replacement therapy, cancer immunotherapy, therapeutic vaccines, regenerative medicine, and genome editing. This review focuses on recent advances, challenges, and future directions in nanoscale platforms designed for mRNA delivery, including lipid and lipid-derived nanoparticles, polymer-based nanoparticles, protein derivatives mRNA complexes, and other types of nanomaterials. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Lipid-Based Structures Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures.
When viewing natural scenes, do abnormal colors impact on spatial or temporal parameters of eye movements? (2012)

Since Treisman's theory, it has been generally accepted that color is an elementary feature that guides eye movements when looking at natural scenes. Hence, most computational models of visual attention predict eye movements using color as an important visual feature. In this paper, using experimental data, we show that color does not affect where observers look when viewing natural scene images. Neither colors nor abnormal colors modify observers' fixation locations when compared to the same scenes in grayscale. In the same way, we did not find any significant difference between the scanpaths under grayscale, color, or abnormal color viewing conditions. However, we observed a decrease in fixation duration for color and abnormal color, and this was particularly true at the beginning of scene exploration. Finally, we found that abnormal color modifies saccade amplitude distribution.
Design and analysis of a large-range micro-gripper (2015)

This paper presents the design and analysis of a new large-range micro-gripper which is constructed using flexure hinges. The gripper is actuated by only one piezoelectric stack actuator (PSA) and the output of the grip arm is approximately rectilinear movement, because the displacement of nonworking direction is extremely small. In order to achieve a large gripping range, a dual-stage amplifier is designed to magnify the stroke of PSA actuator. Analytical models are developed to facilitate the parametric design of the gripper structure. Finite-element analysis simulation is carried out to verify the gripper performance. A prototype gripper is developed for experimental testing. Experimental results show that the maximum output displacement of the device is 365.2 micrometers for one gripper tip under 100 V driving voltage.
Specific volume and compressibility of bilayer lipid membranes with incorporated Na,K-ATPase (2011)

Ultrasound velocimetry and densitometry methods were used to study the interactions of the Na,K-ATPase with the lipid bilayer in large unilamellar liposomes composed of dioleoyl phosphatidylcholine (DOPC). The ultrasound velocity increased and the specific volume of the phospholipids decreased with increasing concentrations of protein. These experiments allowed us to determine the reduced specific apparent compressibility of the lipid bilayer, which decreased by approx. 11% with increasing concentrations of the Na,K-ATPase up to an ATPase/DOPC molar ratio = 2 × 10⁻⁴. Assuming that ATPase induces rigidization of the surrounding lipid molecules one can obtain from the compressibility data that 3.7 to 100 times more lipid molecules are affected by the protein in comparison with annular lipids. However, this is in contradiction with the current theories of the phase transitions in lipid bilayers. It is suggested that another physical mechanisms should be involved for explanation of observed effect.
O Léxico-Gramática, um método de descrição linguística (2013)

Conférence présentée à l'Universidade federal de Minas Gerais, Brésil
An Enhanced (31,11,5) Binary BCH Encoder and Decoder for Data Transmission (2015)

This paper describes the design of (31,11,5) BCH encoder and decoder using mathematical derivation where 31, 11 and 5 represents the block length(n), data length(k) and maximum number of correctable errors(t) respectively. By the use of Galois Field GF(2 5 ) the encoding and decoding are carried out with an irreducible polynomial of x 5 +x 2 +1.The codeword is formed in encoder side by appending redundant bits(R(X)) with the message bit and transmitted through the channel to the decoder side. In the meanwhile, the Flash memory is used to store codeword, later for correction part in decoder side. Decoder involves 3 important steps: 1) The Syndrome calculation(SC), 2) Berlekamp Massey Algorithm (BMA), 3)The Chein Search(CS). The result shows that maximum of 5 errors in any position of 31 bits can be corrected effectively.
Measurement of optic nerve sheath diameter by ultrasound: a means of detecting acute raised intracranial pressure in hydrocephalus (2002)

The evaluation of the optic nerve sheath diameter is a simple non-invasive procedure, which is a potentially useful tool in the assessment and monitoring of children with hydrocephalus suspected of having raised intracranial pressure.