gebhart/patrepeval huggingface dataset:
Kinetic Mechanism of Aspartate-Beta-Semi-Aldehyde Dehydrogenase and it's interaction with small molecule inhibitors (1999)

Conference Abstract| February 01 1999 Kinetic Mechanism of Aspartate-Beta-Semi-Aldehyde Dehydrogenase and it's interaction with small molecule inhibitors C. J. Greenwood; C. J. Greenwood Search for other works by this author on: This Site PubMed Google Scholar K. J. Moore; K. J. Moore Search for other works by this author on: This Site PubMed Google Scholar T. Allinson; T. Allinson Search for other works by this author on: This Site PubMed Google Scholar G. Burton; G. Burton Search for other works by this author on: This Site PubMed Google Scholar C. Frydych; C. Frydych Search for other works by this author on: This Site PubMed Google Scholar F. Harrington; F. Harrington Search for other works by this author on: This Site PubMed Google Scholar N. Nicholson; N. Nicholson Search for other works by this author on: This Site PubMed Google Scholar M. Hartley; M. Hartley Search for other works by this author on: This Site PubMed Google Scholar M. Pearson; M. Pearson Search for other works by this author on: This Site PubMed Google Scholar A. J. Pope A. J. Pope Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1999) 27 (1): A38. https://doi.org/10.1042/bst027a038b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation C. J. Greenwood, K. J. Moore, T. Allinson, G. Burton, C. Frydych, F. Harrington, N. Nicholson, M. Hartley, M. Pearson, A. J. Pope; Kinetic Mechanism of Aspartate-Beta-Semi-Aldehyde Dehydrogenase and it's interaction with small molecule inhibitors. Biochem Soc Trans 1 February 1999; 27 (1): A38. doi: https://doi.org/10.1042/bst027a038b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1999 Biochemical Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.
Binding of a spin-labelled chlorpromazine analogue to calmodulin. (1984)

International audience
ACCURACY OF ORTELIUS800 TM FOR RADIATION-FREE ASSESSMENT OF COBB ANGLE (2009)

Introduction: Accurate and quantitative measurements of the spine are essential for deformity diagnosis and assessment of curve progression. There is much concern related to the multiple exposures to ionizing radiation associated with the Cobb method of radiographic measurement, currently the standard procedure for diagnosis and follow-up of the progression of scoliosis. In addition, the Cobb method relies on two-dimensional analysis of a three-dimensional deformity. The Ortelius800TM aims to provide a radiation-free method for scoliosis assessment in three planes (coronal, sagittal, apical) with simultaneous automatic calculation of the Cobb angle in both coronal and sagittal views. This new device is based on direct measurement of the position of the tips of the spinous processes in space. A low intensity electromagnetic field records the spatial position of a sensor attached to the examiner’s finger while palpating the patient’s spinous processes. This study investigates the correlation of spinal deformity measurements with Ortelius800TM radiation-free system as compared to standard radiographic measured Cobb angles in order to assess Ortelius800TM clinical value while enabling a significant reduction of x-ray exposure. Methods: 124 patients diagnosed with Adolescent Idiopathic Scoliosis (AIS) from four different medical centers were measured with the Ortelius800TM system using the same standard protocol. The entire process required an average of 2 minutes. The Ortelius800TM measurements were correlated with the standard Cobb angle as measured on routine standing coronal and sagittal radiographs. The Pearson correlation coefficient was calculated for matched pair measurements. The mean difference and the absolute mean difference between measurements with the two methods was estimated. Results: Standing full-spine coronal radiographs were obtained for each patient. Radiograph analysis for these 124 patients revealed 249 deformity measurements. The deformity measurements were comprised of 142 thoracic curves with a mean of 18.3° and 107 lumbar curves with a mean of 17.4°. Lateral radiographs were obtained from 38 patients with a mean of 36.1°. Correlation between Cobb angles measured manually on standard erect posteroanterior radiographs and those calculated by this new technique showed an absolute difference between the measurements to be significantly less than +\−5° for coronal measurements and significantly less than +\−6° for sagittal measurements indicating good correlation between the two methods. Pearson’s correlation coefficient between deformity angles obtained by the two methods was highly significant (0.86) with a P value Discussion: The results reveal good correlation between the two measuring methods in both coronal and sagittal views. We propose the Ortelius800TM as a clinical tool for the routine follow-up measurements of AIS patients, thus enabling a significant reduction of radiation exposure.
ChemInform Abstract: An Improvement of the Anderson Test by the Use of High Performance Liquid Chromatography. (1988)

Abstract The model coupling of Z‐Gly‐L‐Phe‐OH with Gly‐O‐Et to give the peptide (Ia) proposed by Anderson to test the racemization in peptide coupling is varied by replacement of the N‐benzyloxycarbonyl group of (Ia) by Z‐Ala.
Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum (2009)

Calreticulin is an ER (endoplasmic reticulum) luminal Ca2+-buffering chaperone. The protein is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. The protein impacts on store-operated Ca2+ influx and influences Ca2+-dependent transcriptional pathways during embryonic development. Calreticulin is also involved in the folding of newly synthesized proteins and glycoproteins and, together with calnexin (an integral ER membrane chaperone similar to calreticulin) and ERp57 [ER protein of 57 kDa; a PDI (protein disulfide-isomerase)-like ER-resident protein], constitutes the 'calreticulin/calnexin cycle' that is responsible for folding and quality control of newly synthesized glycoproteins. In recent years, calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Regulation of Ca2+ homoeostasis and ER Ca2+ buffering by calreticulin might be the key to explain its multi-process property.
Lung is the target organ for a monoclonal antibody to angiotensin-converting enzyme. (1991)

125I-labeled mouse monoclonal antibody (MoAb) to human angiotensin-converting enzyme (ACE), termed 9B9 and cross-reacting with rat and monkey ACE, when injected into the circulation, accumulates in the lung in up to 10 to 20 greater concentrations than in other organs and blood. That 111In-labeled MoAb 9B9 also accumulates in the lungs of both rats and monkeys very selectively, was clearly revealed by gamma-scintigraphy. Unlike polyclonal anti-ACE antibodies that induce an immunodependent lethal reaction when administered intravenously, MoAb 9B9 was well tolerated by rats even at very high doses (up to 300 mg/kg/body weight). At the same time, the administration of this antibody (which does not inhibit the catalytic activity of ACE) resulted in both a 3-fold decrease of the lung ACE activity and an increase in the activity of serum ACE. The highly organ-specific, nondamaging accumulation of the MoAb 9B9 makes it a promising vector for targeted drug delivery to the lung, for modeling of lung pathology, and for gamma-scintigraphic visualization of the lung vascular bed. We also suggest that MoAb 9B9 accumulation in the lung may serve as a highly sensitive marker of lung vessel damage upon various lung pathology.
Environmental and economic assessment of municipal sewage sludge management – a case study in Beijing, China (2013)

A case study was conducted in Beijing to identify municipal sewage sludge (SS) management systems appropriate for a sound material-cycle society. The environmental and economic impacts of four realistic SS-handling scenarios were investigated: stabilization by thermal drying, increased inclusion of SS in cement manufacture, and using either dried or carbonized SS as substitute fuel for coal-fired power generation plants. The results showed that the current sludge management system had the lowest operating cost but higher greenhouse gas (GHG) emissions and a low recycling rate. The case with the use of carbonized SS reused in coal-fired power plants had higher energy consumption and almost the same GHG emissions as the current system. On the other hand, the case including more SS in cement manufacture had the same level of energy consumption with much lower GHG emissions. The case with the use of dried SS in coal-fired power plants also resulted in lower energy consumption and lower GHG emissions than at present. Furthermore, sensitivity analysis showed that drying SS with surplus heat from cement plants used less energy and emitted less GHG compared to the other two drying methods.
Far-red Light Supplemented with Weak Red Light Promotes Flowering of Gypsophila paniculata (2012)

A low red (R): far-red (FR) ratio is known to promote flowering of Arabidopsis and several long-day cut flowers, whereas not much information is available on the effects of single light qualities and their combinations on flowering. Therefore, the effects of light quality on the flowering of Gypsophila paniculata were investigated using light-emitting diodes (LEDs) emitting the following lights: FR, R, and blue (B). Flowering and flower budding were observed under long-day conditions with FR, while no flowering was observed under short-day conditions. Promotion of flowering and flower budding was increased under FR supplemented with R compared to FR alone. Although generally R inhibits flowering in long-day plants, a certain intensity of R, for example, the R:FR ratio between 0.23 and 0.71, may be necessary for effective promotion of flowering. In contrast, B supplementation of FR was not effective at the ratio in this study in inducing flowering and flower budding. The quality of cut flowers produced under long-day conditions with LEDs that promoted flowering was not lower than that under incandescent lamps. These results will provide basic knowledge for the development of LED bulbs as a replacement for incandescent bulbs.
Tight‐Binding Simulation of an InGaN/GaN Quantum Well with indium Concentration Fluctuation (2002)

The electronic properties of InGaN quantum wells with In composition fluctuation were investigated within a tight-binding model, using a new sp3s*d5 parametrization allowing for a correct treatment of strain effects. An experimental In concentration profile measurement was used to build a simulation supercell consistent with the real In distribution inside the InGaN layer. The calculated fundamental electronic transitions exhibit a Stokes shift from 50 meV to 100 meV between In rich and more homogeneous regions of the well, indicating that the formation of In rich clusters play a fundamental part in the optical properties of InGaN based devices.
Effects of Semistarvation on Skeletal Homeostasis* (1980)

Rats were semistarved over a 7-week period, resulting in a loss of 28.2 +/- 1.6% (SEM) of their initial body weights, while ad libitum fed controls gained 15.1 +/- 1.8% (SEM). Bone loss occurred and skeletal turnover was markedly reduced in the semistarved rats, as evidenced by a paucity of osteoid and osteoclasts, failure of the bone to assume a tetracycline label, and reduced urinary hydroxyproline excretion. Despite these changes, there were no alterations of serum or bone alkaline phosphatase activity with semistarvation, and analysis of tibial mineral content revealed reductions only in magnesium and sodium. The malnourished animals, however, were hypercalciuric and hypophosphatemic. Semistarvation had no effect on circulating levels of immunoreactive parathyroid hormone or 25-hydroxyvitamin D, but did result in reduced serum levels of corticosterone, insulin, and 1,25-dihydroxyvitamin D. Therefore, it appears that the effects of semistarvation on the rat skeleton are osteoporotic rather than osteomalacic, and that the defect is the consequence of reduced bone turnover. The contribution which the abnormalities of bone-regulating hormones play in the genesis of this skeletal lesion remains to be determined.
Clinical Electroretinography, Proceedings of the Third International Symposium. (1967)

This book records the proceedings of the third symposium of the International Society for Clinical Electroretinography. It contains 34 articles contributed by over 50 authors. The articles go wide afield and deal either directly or indirectly with many aspects of the electrophysiology of the visual sensory system. Some of the articles are only indirectly related to the subject of electroretinography. There are articles concerned with the apparatus and technique for obtaining the elecroretinogram and for measuring its potentials. There are reports of parallel observations of electrical changes in both the electroretinogram and electroencephalogram and the employment of electrophysiological techniques to explain phenomena such as color vision. There is also a discussion on electro-oculography. Special background is needed to critically evaluate each article and this is the province of the reader. The electroretinogram and other electrophysiological techniques provide insight into retinal physiology and into the physiology of the visual system in
Permanent magnet materials (1968)

Permanent magnets are finding ever-increasing uses as magnet technology develops and materials improve. Permanent magnet materials are evaluated in terms of the geometry and configuration of the application for which they are intended. The origin of the properties of most modern permanent magnet materials is interpreted in terms of fine-particle theory. The fine-particle structures are produced either synthetically or by a solid-state precipitation reaction in an alloy. The preparation and properties of commercial magnets are described. The Alnico alloys are based on magnetically heat-treated iron-nickel-aluminum-cobalt alloys and account for the great majority of present-day production. Ferrites are finding increasing use. Elongated single-domain fine-particle magnets and other materials are used in smaller quantities. A number of interesting, not yet commercial, materials deriving their properties primarily from crystal anisotropy are described.
CO<sub>2</sub>-Protected Amine Formation from Nitrile and Imine Hydrogenation in Gas-Expanded Liquids (2004)

Gas-expanded liquids are tunable media for reaction and separation. We report that gas-expanded liquids under CO2 pressure are unique media for amine formation and separation. In the heterogeneous hydrogenation of benzonitrile and phenylacetonitrile with NiCl2/NaBH4 in CO2-expanded ethanol, the primary amines are protected by CO2 so that the yield of the primary amines is greatly increased and the production of the secondary amines is effectively suppressed. In the homogeneous hydrogenation of benzonitrile and phenylacetonitrile with RhH(P-i-Pr3)3 and benzophenone imine with Rh(1,5-C8H12){P(C6H5)3}2]PF6 in CO2-expanded tetrahydrofuran, the primary amines are separated in situ in the form of solid carbamic acids and/or ammonium carbamates with increased yield while the catalyst remains in the solution. These results demonstrate the potential for using modest pressures of CO2 to facilitate reactions as well as to separate products.
Tetra-n-propylammonium perruthenate (TPAP)-catalysed oxidations of alcohols using molecular oxygen as a co-oxidant (1997)

Tetra-n-propylammonium perruthenate (TPAP) has been used as an efficient catalyst for the conversion of primary and secondary alcohols to the corresponding aldehydes and ketones under very mild aerobic conditions.
Widely tunable continuous-wave Cr^3+:LiSrAlF_6 ring laser from 800 to 936 nm (1998)

We report on a widely tunable, diode-pumped, continuous-wave, single-frequency Cr(3+):LiSrAlF(6) laser with a novel double-ring cavity configuration. The optical diode and the tuning element were located in the ring subcavity to decrease their insertion loss. Using an 1800-lines/mm grating as the tuning element, we obtained a laser emission of 20-mW output power at 870 nm and a tuning range of from 800 to 936 nm. When we used a 1200-lines/mm grating with a higher diffraction efficiency, the laser had a slightly wider tuning range of from 800 to 938 nm. However, the output power decreased at this tuning range.
UNE UTILISATION DE L'INCLINOMETRE DE PRECISION LPC TYPE A 200 A. (1974)

DANS LE CADRE D'UN CHANTIER, LE LABORATOIRE REGIONAL DE BORDEAUX A ETE AMENE A CONTROLER L'INCLINAISON PRISE PAR DES PALPLANCHES AU COURS DU BATTAGE D'UN RIDEAU A L'AIDE D'INCLINOMETRES DE PRECISION. LA METHODE CONSISTE A RECONSTITUER LA DEFORMEE D'UN TUBE MIS EN PLACE DANS LA STRUCTURE A L'AIDE D'UNE SONDE DESCENDUE A L'INTERIEUR. LA SONDE UTILISE UN SYSTEME A PENDULE DONNANT UNE DEVIATION ANGULAIRE. LES OPERATIONS SE RAMENENT A UNE OU PLUSIEURS MESURES D'ANGLE, LA COURBE DE LA DEFORMEE ETANT RECONSTITUEE A PARTIR D'ELEMENTS D'ARC DE LONGUEUR EGALE A LA LONGUEUR DE LA SONDE. LE TUBE NE POUVANT ETRE UN TUBE SOUPLE PVC CLASSIQUE A ETE REMPLACE PAR UN TUBE METALLIQUE CARRE SOUDE SUR LES PALPLANCHES. CETTE DISPOSITION LE LONG DU PROFILE PERMET D'EFFECTUER DES MESURES DE DEFORMATIONS A L'AVANCEMENT ET DE PRENDRE RAPIDEMENT LES DISPOSITIONS NECESSAIRES POUR PALLIER UN DEPLACEMENT EVENTUEL PAR TROP IMPORTANT DU RIDEAU EN COURS DE BATTAGE. LES MESURES EFFECTUEES DANS LE TEMPS POUR LE RIDEAU DE PALPLANCHES AU REPOS SONT TRES HOMOGENES.
Investigation of Real-Time Microstructure Evolution in Steep Thermal Gradients Using in-Situ Spatially Resolved X-ray Diffraction:  A Case Study for Ti Fusion Welds (1998)

A recently developed spatially resolved X-ray diffraction (SRXRD) technique utilizing intense synchrotron radiation has been refined to yield phase and microstructural information down to 200 μm in spatial extent in materials subjected to steep thermal gradients during processing. This SRXRD technique has been applied to map completely the phases and their solid-state transformation in the so-called heat-affected zone (HAZ) in titanium fusion welds in situ during the welding process. Detailed profile analysis of the SRXRD patterns revealed four principal microstructural regions at temperature in the vicinity of the HAZ surrounding the liquid weld pool: (i) a completely transformed β-Ti zone 2−3 mm adjacent to the liquid weld pool; (ii) a mixed α+β-Ti region surrounding the pure β-Ti zone, (iii) a back-transformed α-Ti zone on the backside of the HAZ where pure β-Ti once existed at temperature well above the α → β transformation isotherm, and (iv) a more diffused region outside the HAZ where annealing and recrystallization of the α-Ti base metal occur. The high-temperature microstructures so derived corroborate well the expected transformation kinetics in pure titanium, and the observed phase transformation boundaries are in good agreement with those predicted from the transformation isotherms calculated from a simplified heat-flow model. Based on a detailed assessment of the SRXRD setup employed, improved experimentations such as a smaller beam spot emitted from third generation synchrotron sources, better mechanical stability (tighter scattering geometry), and use of an area detector would enable more quantitative structural information for future phase dynamics studies exemplified by this work.
Compounding of Phosphazenes for Military Applications (1986)

Abstract : Polyphosphazene work at NRDEC is reviewed in the light of the need for end items with resistance to flame and thermal hazards, low temperature flexibility, and resistance to petroleum solvents. The polyphosphazene polymers have been introduced into two end items, which are essentially gaskets. These items are discussed but, in general, emphasis is which are essentially gaskets. These items are discussed but, in general, emphasis is placed on attempts by the Natick RD&E Center to utilize the polymer for wider applications.
Acquired Partial Corticosterone Methyl Oxidase Type II Defect in Diabetes Mellitus: Case of Hyperreninemic Hypoaldosteronism (1990)

The aim of this study was to investigate the pathogenesis of hypoaldosteronism in diabetes. Endogenous elevation of plasma renin activity and exogenous corticotropin were used to study steroidogenesis. Observations were made over 12 yr on the evolution and treatment of hyperkalemia in a diabetic subject. In 1977, potassium, baseline cortisol, aldosterone, and renin activity were normal; renin activity increased normally with posture; and cortisol responded normally to ACTH infusion. Nine yr later, persistent hyperkalemia was documented. Upright renin activity was elevated to 5.26 ng.L-1.s-1, with concomitant elevation of 18-hydroxycorticosterone (18-OHB) and a low-normal aldosterone level. One hour after administration of 0.25 mg i.m. cosyntropin, cortisol increased normally, aldosterone increased from 220 to 360 pM, and 18-OHB increased from 3700 to 4800 pM. During treatment with fludrocortisone, fludrocortisone with furosemide, and furosemide alone, improvement of hyperkalemia was noted. Endogenous hyperreninemia and basal elevations of 18-OHB, accompanied by limited aldosterone responsiveness to renin and ACTH, suggest the presence of a partial corticosterone methyl oxidase type II defect. Evolution of hyperkalemia between 1977 and 1986 suggests this defect was acquired.
MAXIM science and technology (2004)

The Micro Arcsecond X-ray Imaging Mission (MAXIM) has been proposed to NASA in response to the Black Hole Imager line in the newly created "Beyond Einstein" program. Meeting the scientific goals of event horizon imaging has created a new set of technical challenges for the Maxim team. Certainly the most difficult of these is the need for 0.1 micro-arcsecond resolution imaging in the x-ray. We will review the key scientific challenges and show how they flow down into instrument requirements. We will then review our baseline design, discuss the array of technical challenges facing Maxim, and present the current status of our technology.
Sequences and Series (2012)

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Clearance of [14C] polyamines from plasma and erythrocytes in the rat. (1980)

The [14C] polyamines, putrescine, spermidine and spermine were administered intravenously to rats. Arterial blood samples were obtained 2, 4, 6, 12, 20, 30, 60 and 120 min. after injection. Plasma and erythrocyte fractions were separated and assayed for [14C] activity. The clearance of radiolabelled polyamines from both the plasma and erythrocytes was rapid. Within 10 min. of injection, plasma putrescine had decreased by 70%, spermine by 80% and spermidine by 85%. In the same time interval the erythrocyte putrescine level had decreased by 50%, spermine by 70% and spermidine by 80%. This data suggests that exogenously injected radiolabelled polyamines and presumably endogenously produced polyamines are rapidly cleared from the circulation.
Influence of Deposition Parameters on the Optical Properties of DC Magnetron Sputtered Tungsten Oxide Films (2014)

Influence of Deposition Parameters on the Optical Properties of DC Magnetron Sputtered Tungsten Oxide Films