gebhart/patrepeval huggingface dataset:
Cholera toxin-fat cell interaction and the mechanism of activation of the lipolytic response (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCholera toxin-fat cell interaction and the mechanism of activation of the lipolytic responsePedro CuatrecasasCite this: Biochemistry 1973, 12, 18, 3567–3577Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://pubs.acs.org/doi/10.1021/bi00742a033https://doi.org/10.1021/bi00742a033research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Transplantability and Antigenicity of Two Sublines of the TA3 Tumor (1973)

Abstract Loss of specificity in the strain A mammary ascites carcinoma subline TA3-Ha appears to be related to decreased immunogenicity rather than to increased immunoresistance. Allogeneic hosts could be induced to reject potentially lethal inocula of TA3-Ha cells by addition of cells from the more specific TA3-St subline or by presensitization with skin grafts from strain A mice. The nonspecific TA3-Ha subline absorbed markedly less activity from H-2 antisera than strain-specific TA3-St cells; however, the absorption capacity of nonspecific TA3-Ha cells for H-2 antisera was noticeably increased by lyophilization, suggesting decreased exposure of H-2 antigens at the cell surface of intact TA3-Ha cells. It is suggested that inaccessibility of histocompatibility antigens on the TA3-Ha cell may be related to presence of a unique sialoglycoprotein at the cell surface in this tumor subline. With the strain-specific TA3-St subline, lyophilization increased H-2k antigenicity while decreasing H-2d activity. The magnitude of these changes, however, was much less than that observed with either H-2d or H-2k antigenicity after lyophilization of TA3-Ha cells.
Sound propagation in capillary-tube-type porous media with small pores in the capillary walls (1991)

Sound propagation in gas-filled capillary-tube-type porous media was investigated. The capillary tubes were taken to be nominally straight with very small pores in the walls of the capillary tubes. The complex wave number and the characteristic impedance of such media were evaluated. Application to ceramic samples having capillary pores with square cross sections and porous walls is developed as an explanation for the anomalous tortuosity factor previously inferred for this material. Specific acoustic impedance (SAI) measurements were performed for rigid-backed square pore ceramic media having finite wall porosity. It is shown that phase velocity is decreased, attenuation is increased, and characteristic impedance is decreased by finite wall porosity. SAI measurements were also performed after the wall pores were filled with water. These measurements agree favorably with the porous wall and nonporous wall theories, respectively. This work provides a model for the acoustical properties of gas-filled monolithic catalyst supports of which the square pore ceramic media is an example.
<title>Change of optical, electrical, and structural properties of sputtered indium tin oxide films by application of a new reactive sputter atmosphere</title> (1994)

Highly qualitative indium tin oxide (ITO) films were deposited by reactive dc-sputter technique on glass and quartz substrates. Both pure H<SUB>2</SUB>O vapor and pure O<SUB>2</SUB> have been used as reactive sputtering atmosphere. The optical constants refractive index and absorption coefficient were calculated from reflection and transmission spectra in the infrared (IR) region. Using the Drude theory the electrical parameters free carrier concentration and carrier mobility of the ITO-films were contactless determined from IR reflection spectra. The dc-H<SUB>2</SUB>O-sputtered ITO-films show improved optical and electrical properties. For application as transparent window material they distinguish by high visual (VIS) transmittance and high IR- reflectance. Moreover these ITO-films show a high free carrier concentration of N equals 6 X 10<SUP>20</SUP> cm<SUP>-3</SUP> directly after deposition compared with N equals 4 X 10<SUP>20</SUP> cm<SUP>-3</SUP> for dc-O<SUB>2</SUB>-sputtered ITO-films after thermal annealing. The differences between optical and electrical properties of de-O<SUB>2</SUB>- and dc-H<SUB>2</SUB>O-sputtered ITO-films are discussed in regard to their crystal structure and surface morphology.
Bioprocess characterization and intensification: a step ahead with physical approach and instrumentation (2012)

In: Bioprotech International Conference on Bioproduction, BICB 2012, Sfax, Tunisia, 05-08 November 2012<br/>In: Bioprotech International Conference on Bioproduction, BICB 2012, Sfax, Tunisia, 05-08 November 2012
Intra-electron transfer induced by protonation in copper-containing nitrite reductase (2018)

The inter- and intra-electron and proton transfers in the nitrite reduction of copper-containing nitrite reductase (CuNiR) were investigated by using the QM/MM method with the calculational models containing type 1 (T1) and type 2 (T2) Cu sites. The electron transfer from the outer electron donor protein to the T1 Cu site occurred both before and after nitrite binding, and nitrite binding lowered the reduction potential of the Cu T1 site. The protonation of catalytic His244 subsequent to nitrite binding and T1 Cu reduction induced partial intra-electron transfer from T1 to T2 Cu sites. The proton transfer from His244 to nitrite bound on the T2 Cu site via the hydrogen bond network induced intra-electron transfer from the T1 to T2 Cu site. The interaction of the T1 Cu ligand with the second sphere amino acid residues and water molecules affected the reduction potential of the T1 Cu site. The water molecules in the so-called proton pool have an important role in the regulation of the basicity of His244. The conformation of the sensor loop did not change along the reaction, but the water molecule network extending along the sensor loop was changed by nitrite binding.
The Effect of Nonporous PTFE-Covered Stents on Intimal Hyperplasia following Balloon Arterial Injury in Minipigs (1998)

Purpose: To report an experimental study investigating the ability of nonporous polytetrafluoroethylene (PTFE) covering on a metallic stent to retard the development of neointimal hyperplasia (NIH). Methods: Three groups of Hanford miniature swine underwent standardized balloon injury to both external iliac arteries. Group I animals (control) received balloon injuries only. Group II had the site of balloon injury supported by a properly sized, balloon-expandable Palmaz stent placed directly over the injury site. Group III animals received a Palmaz stent covered with PTFE graft. All animals underwent arteriography immediately after intervention and again prior to sacrifice and specimen harvest at 4 weeks. The specimens were examined grossly and histologically at the proximal, middle, and distal segments for NIH development. Results: Uncovered stents developed significantly more NIH (p < 0.0001) and greater luminal narrowing (p < 0.001) than the controls. PTFE-covered stents (group III) exhibited less NIH (p < 0.001) and luminal reduction (p < 0.01) than bare stents (group II) at the middle portion of the stent-graft, but the PTFE cover had no effect on NIH and lumen reduction at the proximal or distal ends of the prosthesis. Conclusions: PTFE-covered stents retarded NIH at 4 weeks, but only at the midportion of the devices; the covering did not prevent neointimal pannus ingrowth at the proximal and distal ends.
Release Engineering 3.0 (2018)

This theme issue aims to stimulate industry practitioners and researchers to reflect on what future release-engineering practices and tools could look like and how they could evolve out of more-advanced forms of current release engineering. Each of the four articles in this issue highlights a different facet of release engineering, with two articles focusing on fundamental technologies and practices and two articles discussing new application domains.
Critical current distribution in spin-transfer-switched magnetic tunnel junctions (2005)

The spin transfer switching current distribution within a cell was studied in magnetic-tunnel-junction-based structures having alumina barriers with a resistance-area product (RA) of 10–30Ωμm2 and a tunneling magnetoresistance of ∼20%. These were patterned into current perpendicular to plane configured nanopillars having elliptical cross sections of area ∼0.02μm2. The width of the critical current distribution (sigma∕average of distribution), measured using 30-ms current pulse width, was found to be 7.5% and 3.5% for cells with thermal factor (KuV∕kBT) of 40 and 65, respectively. The distribution width did not change significantly for pulse widths between 1s and 4ms. An analytical expression for probability density function, p(I∕Ic0) was derived considering the thermally activated spin transfer model, which supports the experimental observation that the thermal factor is the most significant parameter in determining the within-cell critical current distribution width.
Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080 (1993)

1. The imidazoline alpha 2-adrenoceptor antagonist, efaroxan, stimulates insulin secretion from rat isolated islets and antagonizes the ability of diazoxide to inhibit glucose-induced insulin secretion. These effects result from closure of ATP-sensitive potassium channels although the mechanisms involved have not been elucidated. 2. In the present work, we have examined the effects of a close structural analogue of efaroxan, RX801080, in rat isolated islets of Langerhans. RX801080 was found to be ineffective as a stimulator of insulin secretion and did not prevent the inhibition of insulin secretion mediated by diazoxide. 3. RX801080 acted as an antagonist of the actions of several imidazolines (efaroxan, phentolamine and midaglizole) in rat islets. It dose-dependently inhibited the ability of efaroxan to antagonize the effects of diazoxide in islets and also completely inhibited the direct stimulation of insulin secretion mediated by efaroxan. 4. RX801080 also antagonized the effects of the non-imidazoline, ATP-sensitive potassium channel blocker, glibenclamide, in rat islets. It inhibited both the capacity of glibenclamide to stimulate insulin secretion and the ability of glibenclamide to overcome the inhibitory effects of diazoxide in rat islets. 5. Antagonism of glibenclamide responses by RX801080 was not due to inhibition of binding of the sulphonylurea to its receptor on the pancreatic beta-cell. 6. The results suggest that imidazoline compounds and sulphonylureas interact with distinct binding sites on islet cells, but that these sites can interact functionally to control islet cell ATP-sensitive potassium channel activity and insulin secretion.
Transcriptional Phase Variation at the <i>flhB</i> Gene of <i>Pseudomonas putida</i> DOT-T1E Is Involved in Response to Environmental Changes and Suggests the Participation of the Flagellar Export System in Solvent Tolerance (2004)

Frameshift mutations in a poly(G) track at the flhB gene of Pseudomonas putida DOT-T1E are responsible for the diminished swimming of this strain on semisolid medium, which contrasts with the high swimming ability of P. putida KT2440, which does not exhibit a poly(G) track at the flhB gene. We previously showed that a mutant lacking FlhB was more sensitive to solvents than the wild-type strain (Segura et al., J. Bacteriol., 183:4127-4133, 2001). In this study, we show that swimming ability correlates with solvent tolerance in P. putida DOT-T1E, so that growth conditions favoring a functional flhB gene (growth on semisolid medium) resulted in increased innate tolerance to a sudden toluene shock.
Analyses communicationnelles de dialogues finalisés (1994)

Le travail porte sur l'analyse de dialogues finalises dans une perspective communicationnelle. La demarche est empirique: constitution, segmentation et analyses de dialogues humains autour d'une tache. Les analyses sont communicationnelles: elles se focalisent sur l'effet, sur le dialogue, des relations entre interlocuteurs et de leurs connaissances communes
Tandem Polar/Radical Crossover Sequences for the Formation of Fused and Bridged Bicyclic Nitrogen Heterocycles Involving Radical Ionic Chain Reactions, and Alkene Radical Cation Intermediates, Performed under Reducing Conditions: Scope and Limitations. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening (2018)

Cancer genomics consortia have charted the landscapes of numerous human cancers. Whereas some mutations were found in classical oncogenes and tumor suppressors, others have not yet been functionally studied in vivo. To date, a comprehensive assessment of how these genes influence oncogenesis is lacking. We performed direct high-throughput in vivo mapping of functional variants in an autochthonous mouse model of cancer. Using adeno-associated viruses (AAVs) carrying a single-guide RNA (sgRNA) library targeting putative tumor suppressor genes significantly mutated in human cancers, we directly pool-mutagenized the livers of Cre-inducible CRISPR (clustered regularly interspaced short palindromic repeats)-associated protein 9 (Cas9) mice. All mice that received the AAV-mTSG library developed liver cancer and died within 4 months. We used molecular inversion probe sequencing of the sgRNA target sites to chart the mutational landscape of these tumors, revealing the functional consequence of multiple variants in driving liver tumorigenesis in immunocompetent mice. AAV-mediated autochthonous CRISPR screens provide a powerful means for mapping a provisional functional cancer genome atlas of tumor suppressors in vivo.
Blanket and shield nuclear analysis of a D-D tandem mirror reactor (1981)

Numerous revolutionary space missions have been initiated and planned for the following decades, including plans for novel spacecraft, exploration of the deep universe, and long duration manned space trips. Compared with space missions conducted over the past 50 years, current missions have features of spacecraft miniaturization, a faster task cycle, farther destinations, braver goals, and higher levels of precision. Tasks are becoming technically more complex and challenging, but also more accessible via commercial space activities. Remarkably, microfluidics has proven impactful in newly conceived space missions. In this review, we focus on recent advances in space microfluidic technologies and their impact on the state-of-the-art space missions. We discuss how micro-sized fluid and microfluidic instruments behave in space conditions, based on hydrodynamic theories. We draw on analyses outlining the reasons why microfluidic components and operations have become crucial in recent missions by categorically investigating a series of successful space missions integrated with microfluidic technologies. We present a comprehensive technical analysis on the recently developed in-space microfluidic applications such as the lab-on-a-CubeSat, healthcare for manned space missions, evaluation and reconstruction of the environment on celestial bodies, in-space manufacturing of microfluidic devices, and development of fluid-based micro-thrusters. The discussions in this review provide insights on microfluidic technologies that hold considerable promise for the upcoming space missions, and also outline how in-space conditions present a new perspective to the microfluidics field.
Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS) (2005)

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a newly described disorder that occurs in premutation carriers of the fragile X mental retardation 1 (FMR1) gene. Fifty-six patients with FXTAS were given 98 prior diagnoses: most were in the categories of parkinsonism, tremor, ataxia, dementia, or stroke. Data from this study and others were used to develop guidelines for FMR1 diagnostic testing for FXTAS.
High-power AlInGaN-based violet laser diodes with InGaN optical confinement layers (2008)

InGaN optical confinement layers (OCLs) were introduced into blue-violet AlInGaN-based laser diodes (LDs), resulting in the drastic improvements of lasing performance. Comparing with conventional LD structure, the lowest threshold current density of 2.3kA∕cm2 has been achieved by adding 100-nm-thick InGaN OCLs which represented maximum optical confinement factor. Additionally, we observed the high quantum efficiency and the uniform emission intensity distribution of InGaN quantum wells grown on lower InGaN OCL than on typical GaN layer. Upper InGaN OCL can reduce Mg diffusion from p-type layers to InGaN active region by separating the distance between InGaN quantum wells and p-type layers.
Inside Cover: Controlling Bacterial Biofilms (ChemBioChem 14/2009) (2009)

The inside cover picture shows a few examples of small molecules investigated for biofilm control that either inhibit biofilm formation or disperse existing bacterial biofilms. The confocal images show P. aeruginosa:gfp bacteria that have formed a biofilm (upper left) in comparison to a biofilm population dispersed by a 2-aminoimidazole derivative (lower right). For more details, see the Minireview by C. Melander and J. J. Richards on p. 2287 ff.
Low dislocation densities and long carrier lifetimes in GaN thin films grown on a SiNx nanonetwork (2007)

Significant improvement of structural and optical qualities of GaN thin films on sapphire substrates was achieved by metal organic chemical vapor deposition with in situ SiNx nanonetwork. Transmission electron microscope (TEM) studies revealed that screw- and edge-type dislocations were reduced to 4.4×107 and 1.7×107cm−2, respectively, for a ∼5.5-μm-thick layer. Furthermore, room temperature carrier lifetimes of 2.22 and 2.49ns were measured by time-resolved photoluminescence (TRPL) for samples containing single and double SiNx network layers, respectively, representing a significant improvement over the previous studies. The consistent trends among the TEM, x-ray diffraction, and TRPL measurements suggest that in situ SiNx network reduces line defects effectively as well as the point-defect-related nonradiative centers.
Design and assurance strategy for the NRL Pump (1998)

The NRL Pump forwards messages from a low level system to a high level system and monitors the timing of acknowledgments from the high level system to minimize leaks. It is the keystone to a proposed architecture that uses specialized high assurance devices to separate data at different security levels. We describe the software design and assurance argument strategy for this device, the Network NRL Pump, which can be used in any multilevel secure distributed architecture. We have completed the system requirements and logical design of a prototype pump and are working on its physical design.
Rate constant of propagation reaction in stationary state of cationic polymerization. Part II. Rate constant of the propagation reaction of alkyl vinyl ethers‐iodine systems (1961)

Abstract Rate constants of the propagation reaction (k p ) of isobutyl vinyl ether and 2‐chloroethyl vinyl ether initiated by iodine were obtained in ethylene chloride and in n ‐hexane by the method proposed in the proceeding paper. Also in these systems, it was noticed that k p value increased as the dielectric constant of the polymerization system increased. k p values of these two monomers mentioned above were compared with their monomer reactivity ratio and it was proved that the numerical values which we obtained coincided well with each other. Thus, the method of determination of k p applied here must have been reasonable.
[Surgery for craniopharyngioma]. (1990)

We present a series of 20 patients (11 males) operated on for craniopharyngioma through a frontal craniotomy during an 11-year period. They ranged in age from 7 months to 58 years (mean 20 years). The most common symptoms were headaches, blurred vision and endocrine disorders. The perioperative mortality was 5% and morbidity 25%. 5 (25%) patients need reoperation; 13 (65%) received additional radiation therapy. In 94% visual function improved. 65% continued to have or developed endocrine problems, although all were well controlled with supplemental therapy. These results, similar to those reported from other centers, justify a combination of radical surgery and radiation therapy for this condition.
Application of the mixed hybrid finite element approximation in a groundwater flow model: Luxury or necessity? (1994)

Selected groundwater flow scenarios are used in a two‐way comparison between the mixed hybrid finite element method and the standard finite element method (also called the conforming finite element method). The simulations presented are performed in the bidimensional case with a triangular space discretization because of its practical interest for hydrogeologists. The basic idea of the mixed procedure is to approximate both the hydraulic potential and the velocity simultaneously and to satisfy an exact water balance for each element. By contrast, the conforming finite element method calculates the potential field everywhere and then calculates the velocity by differentiation of the potential. The conventional approach results in an elementwise constant velocity which can be subject to significant problems because of the normal component discontinuity of the velocity. The mixed hybrid finite element method provides velocities everywhere in the field, as well as potentials at the center of each element and each edge. Moreover, the normal component of the velocity field is continuous between adjacent elements. The results of the simulations are presented in the form of streamlines. To avoid the problem of velocity discontinuity, the method of Cordes and Kinzelbach (1992) is used; it allows the construction of a continuous velocity field from potentials obtained by the conforming finite element method. The comparison studies show that the mixed hybrid finite element is superior to the conforming method in terms of accuracy. It is also superior to the conforming method in terms of computational effort. The potential fields obtained by the mixed hybrid and the conforming finite element methods are the same.