gebhart/patrepeval huggingface dataset:
A gap at a unique location in newly replicated kinetoplast DNA minicircles from Trypanosoma equiperdum. (1985)

Kinetoplast DNA is a network containing thousands of interlocked minicircles. The minicircles replicate as free molecules after release from the network, and their progeny are then reattached (Englund, P. T., (1979) J. Biol. Chem. 254, 4895-4900). In Trypanosoma equiperdum, some of the newly replicated minicircles which have recatenated to the network contain a single gap. This gap is about 10 nucleotides in size and it is in the newly synthesized strand. Based on several criteria (S1 nuclease digestion, denaturing polyacrylamide gel analysis and DNA sequencing), the gap residues at a unique site on the molecule. This site overlaps the sequence GGGGTTGGTGTAA, which is the only common sequence found in all minicircles, from several different species, which have been examined.
The doublesex locus of Drosophila melanogaster and its flanking regions: a cytogenetic analysis. (1991)

The region of the third chromosome (84D-F) of Drosophila melanogaster that contains the doublesex (dsx) locus has been cytogenetically analyzed. Twenty nine newly induced, and 42 preexisting rearrangements broken in dsx and the regions flanking dsx have been cytologically and genetically characterized. These studies established that the dsx locus is in salivary chromosome band 84E1-2. In addition, these observations provide strong evidence that the dsx locus functions only to regulate sexual differentiation and does not encode a vital function. To obtain new alleles at the dsx locus and to begin to analyze the genes flanking dsx, 59 lethal and visible mutations in a region encompassing dsx were induced. These mutations together with preexisting mutations in the region were deficiency mapped and placed into complementation groups. Among the mutations we isolated, four new mutations affecting sexual differentiation were identified. All proved to be alleles of dsx, suggesting that dsx is the only gene in this region involved in regulating sexual differentiation. All but one of the new dsx alleles have equivalent effects in males and females. The exception, dsxEFH55, strongly affects female sexual differentiation, but only weakly affects male sexual differentiation. The interactions of dsxEFH55 with mutations in other genes affecting sexual differentiation are described. These results are discussed in terms of the recent molecular findings that the dsx locus encodes sex-specific proteins that share in common their amino termini but have different carboxyl termini. The 72 mutations in this region that do not affect sexual differentiation identify 25 complementation groups. A translocation, T(2;3)Es that is associated with a lethal allele in one of these complementation groups is also broken at the engrailed (en) locus on the second chromosome and has a dominant phenotype that may be due to the expression of en in the anterior portion of the abdominal tergites where en is not normally expressed. The essential genes found in the 84D-F region are not evenly distributed throughout this region; most strikingly the 84D1-11 region appears to be devoid of essential genes. It is suggested that the lack of essential genes in this region is due to the region (1) containing genes with nonessential functions and (2) being duplicated, possibly both internally and elsewhere in the genome.
CLIENT REPORT : EXTENDING CABIN AIR MEASUREMENTS TO INCLUDE OLDER AIRCRAFT TYPES UTILISED IN HIGH VOLUME SHORT HAUL OPERATION (2003)

This paper presents a study examining air quality in older aircraft that are used frequently for short trips. The air quality in two types of aircraft were monitored - BAe 146 and Boeing 737-300. This report describes the project background, the air quality parameters that were monitored in aircraft cabins, research methodology, and the results of the study.
Discovery And Capture Of Organizational Knowledge From Unstructured Information (2011)

Knowledge of an organization does not merely reside in structured form of information and data; it is also embedded in unstructured form. The discovery of such knowledge is particularly difficult as the characteristic is dynamic, scattered, massive and multiplying at high speed. Conventional methods of managing unstructured information are considered too resource demanding and time consuming to cope with the rapid information growth. In this paper, a Multi-faceted and Automatic Knowledge Elicitation System (MAKES) is introduced for the purpose of discovery and capture of organizational knowledge. A trial implementation has been conducted in a public organization to achieve the objective of decision capture and navigation from a number of meeting minutes which are autonomously organized, classified and presented in a multi-faceted taxonomy map in both document and content level. Key concepts such as critical decision made, key knowledge workers, knowledge flow and the relationship among them are elicited and displayed in predefined knowledge model and maps. Hence, the structured knowledge can be retained, shared and reused. Conducting Knowledge Management with MAKES reduces work in searching and retrieving the target decision, saves a great deal of time and manpower, and also enables an organization to keep pace with the knowledge life cycle. This is particularly important when the amount of unstructured information and data grows extremely quickly. This system approach of knowledge management can accelerate value extraction and creation cycles of organizations.
Synthesis and Functional Properties of End-Dendronized Oligo(9,9-diphenyl)fluorenes (2006)

[structure: see text] A facile approach for the synthesis of a family of dendrimers OFn-EG with hole-transporting ability moieties by copper-catalyzed Buchwald's double-amination as a key reaction has been developed. These novel dendrimers exhibit good energy transfer efficiencies and very high thermal and electrochemical stabilities and have potential applications as hole transfer and emitting layers in the field of organic emitting diodes (OLEDs) or as host materials for electrophosphorescent applications.
Oregon Boundary Settlement (1956)

Graph-based deep learning has shown great promise in cancer histopathology image analysis by contextualizing complex morphology and structure across whole slide images to make high quality downstream outcome predictions (ex: prognostication). These methods rely on informative representations (i.e., embeddings) of image patches comprising larger slides, which are used as node attributes in slide graphs. Spatial omics data, including spatial transcriptomics, is a novel paradigm offering a wealth of detailed information. Pairing this data with corresponding histological imaging localized at 50-micron resolution, may facilitate the development of algorithms which better appreciate the morphological and molecular underpinnings of carcinogenesis. Here, we explore the utility of leveraging spatial transcriptomics data with a contrastive crossmodal pretraining mechanism to generate deep learning models that can extract molecular and histological information for graph-based learning tasks. Performance on cancer staging, lymph node metastasis prediction, survival prediction, and tissue clustering analyses indicate that the proposed methods bring improvement to graph based deep learning models for histopathological slides compared to leveraging histological information from existing schemes, demonstrating the promise of mining spatial omics data to enhance deep learning for pathology workflows.
Pathological assessment of response to induction chemotherapy in breast cancer. (1986)

Macroscopic and microscopic pathology review was used to assess the degree of tumor reduction after preoperative chemotherapy in 90 patients with inflammatory and locally advanced breast cancer. Fifteen (17%) patients had no evident residual macroscopic tumor on gross pathological examination, and 6 of these 15 had no residual tumor on microscopic review either. There was no significant difference in disease-free and overall survival between the six patients with no microscopic disease and the nine patients with only microscopic residual disease but no residual macroscopic tumor. These 15 patients with major reduction after induction chemotherapy had a longer disease-free survival (DFS) (median not reached at 5 yr) than the other 75 patients with lesser degrees of tumor reduction (DFS = 22 mo; P less than 0.01). Clinical evaluation of response to chemotherapy was a less accurate predictor of outcome than was the pathological assessment of response. Complete clinical responders had a 4-yr DFS of 55%, whereas patients with non macroscopic residual tumor following preoperative chemotherapy, less than one-half of whom had been judged to be a complete clinical responder, had a median DFS of greater than 60 mo and a 4-yr DFS of 75%. Patients whose mastectomy specimen had no macroscopic residual disease had a 93% 5-yr survival compared to patients with a less marked response to therapy who had a 5-yr survival of 30% (P less than 0.01). No pretreatment patient or tumor-related variables correlated with the degree of tumor reduction following preoperative therapy. Achievement of a mastectomy specimen free of residual macroscopic tumor after preoperative chemotherapy is an excellent prognostic factor for a prolonged DFS and survival. This information should be considered in the selection of postoperative systemic therapy.
Kinetic applications of electron paramagnetic resonance spectroscopy. XIII. Di-tert-butylmethyl and related radicals (1974)

Di-tert-butylmethyl, B2CH, and a wide variety of related radicals, e.g., B3C, B2CCH2C6H5, B2CCH2P-(O)(OEt)2, etc., are extremely long lived when compared with less highly substituted alkyl radicals. They show no sign of dimerizing even at low temperatures. At ambient temperatures these radicals decay with first-order kinetics and Arrhenius parameters for these reactions are reported. The decay mechanism could not be unequivocally established but it is believed to be either a β scission (e.g., B2CH → B(H)C=CMe2 + Me·) or a 1,3-intramolecular hydrogen atom transfer (e.g., B2CH → BCH2CMe2CH2). At low temperatures most B2CCH2R radicals decay with second-order kinetics, presumably yielding the disproportionation products, B2CHCH2R and B2C=CHR.
A new chaotic secure communication system (2003)

The paper proposes a digital chaotic secure communication by introducing a magnifying glass concept, which is used to enlarge and observe minor parameter mismatch so as to increase the sensitivity of the system. The encryption method is based on a one-time pad encryption scheme, where the random key sequence is replaced by a chaotic sequence generated via a Chua's circuit. We make use of an impulsive control strategy to synchronize two identical chaotic systems embedded in the encryptor and the decryptor, respectively. The lengths of impulsive intervals are piecewise constant and, as a result, the security of the system is further improved. Moreover, with the given parameters of the chaotic system and the impulsive control law, an estimate of the synchronization time is derived. The proposed cryptosystem is shown to be very sensitive to parameter mismatch and hence the security of the chaotic secure communication system is greatly enhanced.
Human and Machine Stick Balancing (2007)

We compared the similarities and differences in stick balancing for the human fingertip and that by a servo-controlled machine. The motion of the stick in both cases exhibited a swinging or hunting behavior, which appears to be related to feedback delay. However, human stick balancing appears also to be affected by psychological factors, such as attention, which are not present in machine control systems. We discuss how machine control systems compare with human stick balancing. We also discuss about the repulsive delayed random walk as a simplified model of the stick balancing.
Does the Duration of Index Episode Affect the Treatment Outcome of Major Depressive Disorder? (2008)

clinicaltrials.gov Identifier: NCT00021528.
Relative Bioavailability of Lamotrigine Chewable Dispersible Tablets Administered Rectally (2001)

Drug prepared from LTG chewable dispersible tablets is absorbed rectally, although not to the same extent as when given orally. Rectal administration of suspension of these tablets can be an acceptable route of administration.
Endoplasmic reticulum (ER) stress detected in the mutated hGBA induced <i>Drosophila</i> eye. (2015)

<p>We used xbp1-EGFP as an ER stress marker in which EGFP is expressed in frame only after ER stress <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0069147#pone.0069147-Ryoo1" target="_blank">[31]</a>. (A) Weak fluorescence is generated in eye imaginal discs expressing the hGBA<sup>WT</sup> construct. The eye imaginal discs of hGBA<sup>R120W</sup> transgenic combinations emitted more fluorescence than that of hGBA<sup>WT</sup> transgenic combination. The eye imaginal discs of hGBA<sup>RecNciI</sup> transgenic combinations emitted the most intense fluorescence. (B) Values generated by different transgenic combinations with fixed quantities of fluorescence intensity (n = 7–15 eye imaginal discs from third instar larvae per transgenic combination). Error bars represent SE. *Significant difference compared with values from GMR control (***P<0.001; Student's t test). (C) Endoplasmic reticulum stress marker gene, dBiP (major ER chaperone) mRNA expression in hGBA<sup>R120W</sup> and hGBA<sup>RecNciI</sup> transgenic combinations was upregulated (n = about 30 fly heads per transgenic combination). Internal control was dRpL32. Error bars represent SE. *Significant difference compared with GMR control (*P<0.05; Student's t test). (D) High levels of hGBAs are expressed in whole bodies of heat-shocked flies. Expression levels of dBiP mRNA of hGBA<sup>R120W</sup> and hGBA<sup>RecNciI</sup> transgenic combinations were also upregulated (n = about 30 flies per transgenic combination). Internal control was dRpL32. Error bars represent SE. *Significant difference compared with hs control (*P<0.05; **P<0.01; ***P<0.001; Student's t test).</p>
From Conflict to Creativity: How Resolving Workplace Disagreements Can Inspire Innovation and Productivity (2001)

This is a guide to unlocking the creative potential of conflict in any organization. Aimed at executives, managers and conflict resolution professionals this text shows how the process of engaging in and resolving conflicts can actually unleash creativity to tremendous advantage in a variety of workplace settings. The book offers a collaborative model for resolving conflict and shows how to develop communication skills, work with personality differences, deal with teams which include a broad spectrum of men, women of different age groups, different races, ethnicity's and cultures, and encourage creativity.
Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults (2018)

High parameter CyTOF can help profile immune components associated with differential vaccine responsiveness.
Effect of the preparation conditions for spherical zirconium hexacyanoferrate(II) on its properties (1987)

The purpose of this study was to prepare granular zirconium hexacyanoferrate(II) by treating gel spheres of zirconium hydroxide with hydrochloric acid solutions of potassium hexacyanoferrate(II), to study the sorption-selective properties and the chemical stability of the sorbent and the possibility of utilizing it in decontaminating nuclear power plants effluents from cesium and cobalt radionuclides.
An AlGaAs/GaAs Concentrator Solar Cell Operating at High Concentration Ratios without Forced Cooling (1982)

A 1×1 cm 2 p-AlGaAs/p-GaAs/n-GaAs concentrator solar cell operating at high concentration ratios without forced cooling is described. The cell has a fairly large junction depth (the thickness of the p-GaAs layer) of 3 µm which reduces the sheet resistance of the surface layer and permits the use of a relatively crude contact grid pattern which is easily fabricated. The cell has its highest fill factor of 0.889 at 50–100 suns and its highest efficiency of 22.7% at 50–200 suns, and also maintains a practical efficiency of 17.6% even at 1025 suns without forced cooling.
"Good Try, Mr. Paul": Populism and the Politics of African Land Use (1983)

Michael Watts, "Good Try, Mr. Paul": Populism and the Politics of African Land Use, African Studies Review, Vol. 26, No. 2, Social Science and Humanistic Research on Africa: An Assessment (Jun., 1983), pp. 73-83
Periventricular rigidity in long-term shunt-treated hydrocephalus (2005)

Object. The failure of ventricles to enlarge after acute shunt malfunction in long-term shunt-dependent patients is generally attributed to the presence of periventricular rigidity resulting from gliosis. The aim of this study was to test the hypothesis that periventricular rigidity is present in these patients. Methods. Fifteen pediatric patients who presented with acute shunt malfunction were studied; slit ventricles were detected in all of these patients. Pressure measurements were recorded simultaneously in both the ventricle and the brain parenchyma during shunt revision and then repeated after bolus infusion of fluid into the ventricle. The mean intraventricular pressure (IVP) at presentation was 24.1 mm Hg (standard deviation 10 mm Hg). The mean baseline IVP after drainage of cerebrospinal fluid but prior to the infusion was 7.5 ± 4.3 mm Hg. There was no significant difference in the increase in the IVP and the intraparenchymal pressure (IPP) after bolus infusion into the ventricle (3.6 ± 2.4 mm Hg and 3.3 ± 2.1 mm Hg, respectively; p = 0.39). The mean pressure volume index was 24.1 ml (standard error of the mean 4.6 ml). Conclusions. The profile of the changes in IVP and IPP indicates that the periventricular wall does not restrict ventricular enlargement following shunt malfunction in long-term shunt-dependent patients.
Dynamics of a Hysteretic Relay Oscillator with Periodic Forcing (2011)

The dynamics of a hysteretic relay oscillator with simple harmonic forcing is studied in this paper. Even though there are no bounded solutions in the absence of forcing, periodic excitation gives rise to more complex responses including periodic, quasi-periodic, and chaotic behavior. A Poincaré map is introduced to facilitate mathematical analysis. Families of period-one solutions are determined as fixed points of the Poincaré map. These represent coexisting subharmonic responses. Conditions on the amplitude and frequency of the forcing for the existence of periodic solutions have been obtained. Linear stability analysis reveals that these solutions can be classified as centers or saddles. The presence of higher periodic or quasi-periodic motions together with homoclinic and heteroclinic tangles implies the existence of chaotic solutions.
Catalytic activity of some chelate polymers derived from cupric ion and polymeric ligands having hydroxamic acid groups (1968)

Abstract The following chelate‐polymers were synthesized and their catalytic activity was investigated: These chelate‐polymers were found to catalyse the decomposition of hydrogen peroxide. For purposes of comparison, the copper‐chelate of methyl hydroxamic acid (IV) also was synthesized; it showed no catalytic effect. The chelates (I) and (II), on the other hand, were found to have large catalytic activity for the decomposition reaction of hydrogen peroxide in aqueous solution, while their polymeric ligands alone exhibited no catalytic activity for this reaction, or, at least, less activity than the chelates themselves. In the case of the chelate (II), it was found that the catalytic activity depends on the molecular weight of the polymeric ligand. On the basis of structural analyses by means of visible and infra‐red spectroscopy, the catalytic activity of these chelate polymers is assumed to depend on the bond strength between the ligand and the copper ion.
Activated Nitriles in Heterocyclic Synthesis: A Novel Synthesis of Pyrazolo[5,6:3',4']pyrano[5,4-b]isoxazoles (1982)

A novel synthesis of pyrano k.3-c]isoxazoles is reported via reaction of 4-arylidene-2-isoxazolin-5-ones
Method for Recovering Anhydrous ZnCl<sub>2</sub>from Aqueous Solutions (1993)

Abstract To develop technology to assure an ample supply of zinc and to reduce environmental pollution, the U.S. Bureau of Mines investigated alternatives to the roast-leach process for treating complex sulfide concentrates. Previous studies proved that low-grade zinc sulfide (ZnS) concentrates could be leached using chlorine-oxygen to produce zinc chloride (ZnCl2). The process involves high energy requirements for evaporating the pregnant solution to produce anhydrous ZnCl2 needed for electrolytic cell feed. An efficient hydrometallurgical process would facilitate treatment of lower grade ores that can be used in conventional processing and would render roasting unnecessary. It is difficult to keep ZnCl2 anhydrous as it is hygroscopic and deliquescent. Therefore, an alternate method of producing a feed material from solution, which could be stored without absorbing H2O, was sought. Zinc diamine chloride [Zn (NH3)2Cl2], was precipitated from solution by adding ammonium chloride (NH4Cl) and sparging with ammonia (NH3) to a pH of 6 to 7.5. The spent solution was treated with calcium hydroxide [Ca (OH)2] at 60° to 80°C for 1 to 4 h to remove remaining zinc and NH3. The Zn (NH3)2Cl2 was heated to 300° to 400°C to remove NH3 and produce anhydrous ZnCl2. A possible flowsheet was devised and will be presented.
Power Token Balancing: Adapting CMPs to Power Constraints for Parallel Multithreaded Workloads (2011)

In the recent years virtually all processor architectures employ multiple cores per chip (CMPs). It is possible to use legacy (i.e., single-core) power saving techniques in CMPs which run either sequential applications or independent multithreaded workloads. However, new challenges arise when running parallel shared-memory applications. In the later case, sacrificing some performance in a single core (thread) in order to be more energy-efficient might unintentionally delay the rest of cores (threads) due to synchronization points (locks/barriers), therefore, harming the performance of the whole application. CMPs increasingly face thermal and power-related problems during their typical use. Such problems can be solved by setting a power budget to the processor/core. This paper initially studies the behavior of different techniques to match a predefined power budget in a CMP processor. While legacy techniques properly work for thread independent/multi-programmed workloads, parallel workloads exhibit the problem of independently adapting the power of each core in a thread dependent scenario. In order to solve this problem we propose a novel mechanism, Power Token Balancing (PTB), aimed at accurately matching an external power constraint by balancing the power consumed among the different cores using a power token-based approach while optimizing the energy efficiency. We can use power (seen as tokens or coupons) from non-critical threads for the benefit of critical threads. PTB runs transparent for thread independent / multiprogrammed workloads and can be also used as a spin lock detector based on power patterns. Results show that PTB matches more accurately a predefined power budget (total energy consumed over the budget is reduced to 8\% for a 16-core CMP) than DVFS with only a 3\% energy increase. Finally, we can trade accuracy on matching the power budget for energy-efficiency reducing the energy a 4% with a 20% of accuracy.