gebhart/patrepeval huggingface dataset:
On Some Directions in Security-Oriented Research (2007)

In recent years, various research projects have been financed in the area of security-oriented research in IT. This paper emphasizes the need for a multidiscipline approach to security research. In particular, it surveys the research areas which are subject of new research project Security-Oriented Research in Information Technology. This research will be performed at the Faculty of Information Technology (FIT), Brno University of Technology in the period 2007-2013. The use of bio-inspired approaches in this project is also discussed.
Analysis of hydrogen adsorption and binding configuration on tungsten surfaces using direct recoil spectroscopy. (2014)

Abstract not provided.
Aldehyde durch hydrogenolytische Spaltung von <i>N</i><sub>1</sub>‐Acyl‐3.5‐dimethyl‐pyrazolen (1959)

Abstract Die Synthese einiger N 1 ‐Acyl‐3.5‐dimethyl‐pyrazole und deren hydrogenolytische Spaltung mit LiAlH 4 zu Aldehyden wird beschrieben.
Cellular Automata Sound Synthesis with an Extended Version of the Multitype Voter Model (2010)

The papers at this Convention have been selected on the basis of a submitted abstract and extended precis that have been peer reviewed by at least two qualified anonymous reviewers. This convention paper has been reproduced from the author&apos;s advance manuscript, without editing, corrections, or consideration by the Review Board. The AES takes no responsibility for the contents.
II TRANSMISSION OF SOUND ENERGY AND THICKNESS OF PLATE TRANSMITTER AT NORMAL INCIDENCE—ULTRASONIC METHOD (1930)

Another and more direct experimental method for determining the reflection from and transmission through parallel-faced partitions of sound energy of short wave-length was studied. Measurements were taken of the energy transmitted through obstructing plates by means of a torsion pendulum placed in the "ultrasonic shadow", the incidence of the energy being normal. The theoretical and experimental results obtained in previous researches by taking reflection measurements only were confirmed, and again it was shown necessary to employ the bulk modulus of elasticity for computations of velocity instead of Young's.
Two-Dimensional Solid-State NMR Reveals Two Topologies of Sarcolipin in Oriented Lipid Bilayers (2006)

Sarcolipin (SLN), a 31 amino acid integral membrane protein, regulates SERCA1a and SERCA2a, two isoforms of the sarco(endo)plasmic Ca-ATPase, by lowering their apparent Ca(2+) affinity and thereby enabling muscle relaxation. SLN is expressed in both fast-twitch and slow-twitch muscle fibers with significant expression levels also found in the cardiac muscle. SLN shares approximately 30% identity with the transmembrane domain of phospholamban (PLN), and recent solution NMR studies carried out in detergent micelles indicate that the two polypeptides bind to SERCA in a similar manner. Previous 1D solid-state NMR experiments on selectively (15)N-labeled sites showed that SLN crosses the lipid bilayer with an orientation nearly parallel to the bilayer normal. With a view toward the characterization of SLN structure and its interactions with both lipids and SERCA, herein we report our initial structural and topological assignments of SLN in mechanically oriented DOPC/DOPE lipid bilayers as mapped by 2D (15)N PISEMA experiments. The PISEMA spectra obtained on uniformly (15)N-labeled protein as well as (15)N-Leu, (15)N-Ile and (15)N-Val map the secondary structure of SLN and, simultaneously, reveal that SLN exists in two distinct topologies. Both the major and the minor populations assume an orientation with the helix axis tilted by approximately 23 degrees with respect to the lipid bilayer normal, but vary in the rotation angle about the helix axis by approximately 5 degrees . The existence of the multiple populations in model membranes may be a significant requirement for SLN interaction with SERCA.
Villancicos i canciones (1995)

Juan Vasquez's 1551 publication of villancicos, surviving in a unique and heretofore inaccessible print, contains twenty-two villancicos a 3, five villancicos a 4, and two canciones a 5. Although Vasquez enjoyed a well-deserved popularity in the Spanish courts during his lifetime, he has been neglected since. The works in this collection amply justify his contemporaneous renown. They range from sprightly settings of folklike tunes and poetry to serious compositions which display outstanding contrapuntal skill and sensitivity.
Gene Rearrangements in Lymphoma (1987)

Clonality is regarded as an important diagnostic feature of B-cell lymphomas, but until recently the clonality of T-cell proliferations could not be directly determined. Elucidation of the genetic events in lymphocytic differentiation has led to the development of an assay for clonality in both B- and T-cell infiltrates. Clonal rearrangement of the immunoglobulin or T-cell receptor genes can be detected by the Southern blot technique. Such rearrangements provide evidence of clonal proliferation, which, in the proper context, can be regarded as a sign of malignancy. The presence of gene rearrangements in poorly differentiated neoplasms may serve as evidence of hematopoietic differentiation, and the pattern of such rearrangements may point to either T- or B-cell lineage. Specific applications to dermatopathology include the evaluation of skin biopsy specimens for cutaneous lymphoma, evaluation of peripheral blood specimens for detection of Sézary's syndrome, and evaluation of lymph nodes and blood for the staging of mycosis fungoides.
IMPROVED TECHNIC FOR DIAGNOSING RINGWORM INFECTIONS AND MONILIASIS (1951)

Although superficial fungus infection of the skin is a common disease, it has been our experience that diagnosis of the condition is often made on the basis of inadequate evidence. Ringworm, especially of the feet, is a popular diagnosis among both physicians and laymen. The diagnosis is usually based on brief clinical inspection without resort to confirmatory laboratory procedures. A false diagnosis of ringworm carries the hazard of exposing the patient to therapeutic attacks that at best may not be helpful, and at worst may be damaging. We have repeatedly had the opportunity to observe patients with various types of contact dermatitis who have received the wrong treatment, often with great harm to themselves, because of a clinical misdiagnosis of ringworm. On the other hand, the failure to make an accurate diagnosis, particularly in the more resistant cases such as ringworm of the nails, entirely precludes rational therapy. Confirmation of
The Stereochemistry of Hydride Reductions (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Stereochemistry of Hydride ReductionsWilliam G. Dauben, Gerhard J. Fonken, and Donald S. NoyceCite this: J. Am. Chem. Soc. 1956, 78, 11, 2579–2582Publication Date (Print):June 1, 1956Publication History Published online1 May 2002Published inissue 1 June 1956https://pubs.acs.org/doi/10.1021/ja01592a069https://doi.org/10.1021/ja01592a069research-articleACS PublicationsRequest reuse permissionsArticle Views1996Altmetric-Citations232LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onset (2003)

Objective To test the hypothesis that the age at onset of bipolar disorder would identify a developmental subtype of bipolar disorder in adults characterized by increased levels of irritability, chronic course, rapid cycling, and comorbidity with attention deficit hyperactivity disorder. Methods Forty-four adult subjects diagnosed with bipolar disorder were selected from large family studies of youth with and without attention deficit hyperactivity disorder. These subjects were stratified by the age at onset in childhood (younger than 13 years; n = 8, 18%), adolescence (13–18 years; n = 12, 27%, or adulthood (older than 19 years; n = 24, 55%). All subjects were administered structure diagnostic interviews and a brief cognitive battery. Results In contrast with adult-onset bipolar disorder, child-onset bipolar disorder was associated with a longer duration of illness, more irritability than euphoria, a mixed presentation, a more chronic or rapid-cycling course, and increased comorbidity with childhood disruptive behavior disorders and anxiety disorders. Conclusion Stratification by age at onset of bipolar disorder identified subgroups of adult subjects with differing clinical correlates. This pattern of correlates is consistent with findings documented in children with pediatric bipolar disorder and supports the hypothesis that child-onset bipolar disorder may represent a developmental subtype of the disorder.
CORDIC-based digital signal processing (DSP) element for adaptive signal processing (1995)

The High Performance Adaptive Weight Computation (HAWC) processing element is a CORDIC based application specific DSP element that, when connected in a linear array, can perform extremely high throughput (100s of GFLOPS) matrix arithmetic operations on linear systems of equations in real time. In particular, it very efficiently performs the numerically intense computation of optimal least squares solutions for large, over-determined linear systems. Most techniques for computing solutions to these types of problems have used either a hard-wired, non-programmable systolic array approach, or more commonly, programmable DSP or microprocessor approaches. The custom logic methods can be efficient, but are generally inflexible. Approaches using multiple programmable generic DSP devices are very flexible, but suffer from poor efficiency and high computation latencies, primarily due to the large number of DSP devices that must be utilized to achieve the necessary arithmetic throughput. The HAWC processor is implemented as a highly optimized systolic array, yet retains some of the flexibility of a programmable data-flow system, allowing efficient implementation of algorithm variations. This provides flexible matrix processing capabilities that are one to three orders of magnitude less expensive and more dense than the current state of the art, and more importantly, allows a realizable solution to matrix processing problems that were previously considered impractical to physically implement. HAWC has direct applications in RADAR, SONAR, communications, and image processing, as well as in many other types of systems.
Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta (2007)

The arterial wall contains a significant amount of charged proteoglycans, which are inhomogeneously distributed, with the greatest concentrations in the intimal and medial layers. The hypothesis of this study is that the transmural distribution of proteoglycans plays a significant role in regulating residual stresses in the arterial wall. This hypothesis was first tested theoretically, using the framework of mixture theory for charged hydrated tissues, and then verified experimentally by measuring the opening angle of rat aorta in NaCl solutions of various ionic strengths. A three-dimensional finite element model of aortic ring, using realistic values of the solid matrix shear modulus and proteoglycan fixed-charge density, yielded opening angles and changes with osmolarity comparable to values reported in the literature. Experimentally, the mean opening angle in isotonic saline (300 mosM) was 15 +/- 17 degrees and changed to 4 +/- 19 degrees and 73 +/- 18 degrees under hypertonic (2,000 mosM) and hypotonic (0 mosM) conditions, respectively (n = 16). In addition, the opening angle in isotonic (300 mosM) sucrose, an uncharged molecule, was 60 +/- 16 degrees (n = 11), suggesting that the charge effect, not cellular swelling, was the major underlying mechanism for these observations. The extent of changes in opening angle under osmotic challenges suggests that transmural heterogeneity of fixed-charge density plays a crucial role in governing the zero-stress configuration of the aorta. A significant implication of this finding is that arterial wall remodeling in response to altered wall stresses may occur via altered deposition of proteoglycans across the wall thickness, providing a novel mechanism for regulating mechanical homeostasis in vascular tissue.
Blood volume: importance and adaptations to exercise training, environmental stresses, and trauma/sickness (2000)

This paper reviews the influence of several perturbations (physical exercise, heat stress, terrestrial altitude, microgravity, and trauma/sickness) on adaptations of blood volume (BV), erythrocyte volume (EV), and plasma volume (PV). Exercise training can induce BV expansion: PV expansion usually occurs immediately, but EV expansion takes weeks. EV and PV expansion contribute to aerobic power improvements associated with exercise training. Repeated heat exposure induces PV expansion but does not alter EV. PV expansion does not improve thermoregulation, but EV expansion improves thermoregulation during exercise in the heat. Dehydration decreases PV (and increases plasma tonicity) which elevates heat strain and reduces exercise performance. High altitude exposure causes rapid (hours) plasma loss. During initial weeks at altitude, EV is unaffected, but a gradual expansion occurs with extended acclimatization. BV adjustments contribute, but are not key, to altitude acclimatization. Microgravity decreases PV and EV which contribute to orthostatic intolerance and decreased exercise capacity in astronauts. PV decreases may result from lower set points for total body water and central venous pressure, while EV decreases may result from increased erythrocyte destruction. Trauma, renal disease, and chronic diseases cause anemia from hemorrhage and immune activation which suppresses erythropoiesis. The re-establishment of EV is associated with healing, improved life quality, and exercise capabilities for these injured/sick persons.
Baculovirus Late Expression Factors (2004)

Autographa californica nuclear polyhedrosis virus, or AcMNPV, is the type member of the baculoviruses, a family of double-stranded DNA viruses with large circular genomes. The successive and concomitant expression of an assortment of early, late and very late genes is instrumental for successful baculovirus infection, and requires a switch from early dependence on a host cell-derived polymerase II to a novel virus-encoded RNA polymerase that is required for transcription later on in infection. A series of repetitive and highly conserved sequences known as homologous regions, or hrs, function both as origins of DNA replication as well as transcriptional enhancers of late gene expression. An array of AcMNPV genes produced early on in infection, known as late expression factors, or LEFs, are essential for both replication and late gene expression. In this review, an overview of baculovirus LEFs and their roles in viral replication and late gene expression is presented. The role of LEFs in determining baculovirus host range is described. Finally, we compare baculovirus replication and transcription machinery with other viral systems.
Pathway of Salicylic Acid Biosynthesis in Healthy and Virus-Inoculated Tobacco (1993)

Salicylic acid (SA) is a likely endogenous regulator of localized and systemic disease resistance in plants. During the hypersensitive response of Nicotiana tabacum L. cv Xanthi-nc to tobacco mosaic virus (TMV), SA levels rise dramatically. We studied SA biosynthesis in healthy and TMV-inoculated tobacco by monitoring the levels of SA and its likely precursors in extracts of leaves and cell suspensions. In TMV-inoculated leaves, stimulation of SA accumulation is accompanied by a corresponding increase in the levels of benzoic acid. 14C-Tracer studies with cell suspensions and mock-or TMV-inoculated leaves indicate that the label moves from trans-cinnamic acid to SA via benzoic acid. In healthy and TMV-inoculated tobacco leaves, benzoic acid induced SA accumulation. o-Coumaric acid, which was previously reported as a possible precursor of SA in other species, did not increase SA levels in tobacco. In healthy tobacco tissue, the specific activity of newly formed SA was equal to that of the supplied [14C]benzoic acid, whereas in TMV-inoculated leaves some isotope dilution was observed, presumably because of the increase in the pool of endogenous benzoic acid. We observed accumulation of pathogen-esis-related-1 proteins and increased resistance to TMV in benzoic acid- but not in o-coumaric acid-treated tobacco leaves. This is consistent with benzoic acid being the immediate precursor of SA. We conclude that in healthy and virus-inoculated tobacco, SA is formed from cinnamic acid via benzoic acid.
Enantiospecific Synthesis of (+)‐Hyacinthacine A<sub>2</sub> (2006)

Abstract We report an efficient synthesis of (+)‐hyacinthacine A 2 in six steps from ( S )‐ N ‐Cbz‐vinylgylcine. The key strategies were the olefin cross metathesis (CM), Sharpless asymmetric dihydroxylation, and a sequential double reductive cyclization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Tests for penicillin allergy in man. II. The immunological cross-reaction between penicillins and cephalosporins. (1974)

The immunological cross-reaction between penicillins and a cephalosporin derivative (cephaloridine CEPR) has been investigated. Cross-allergenicity was studied in twenty-four patients with established penicillin allergy using a variety of tests. Skin tests, quantitative leucocyte challenge (estimating histamine release by allergen) and lymphocyte stimulation (transformation) tests were performed, using CEPR, conjugates of CEPR with human serum albumin (HSA) and bovine gamma-globulin (BGG), benzylpenicillin and benzylpenicilloyl (BPO) conjugates with HSA and BGG. A cross-reaction was clearly established in the majority of patients. The highest percentage of positive results (cross-allergenicity) was obtained in the leucocyte challenge test (80 per cent with CEPR.BGG), followed by the lymphocyte stimulation test (50 per cent with CEPR.BGG), and then the skin test (46 per cent with CEPR.HSA). None of ten non-allergic controls gave a positive result in these tests. Three of the penicillin allergic patients had received cephaloridine, and all three developed allergic reactions. Cross-antigenicity has also been shown by haemagglutination and haemagglutination-inhibition tests on serum from larger groups of penicillin-allergic patients (including the previously mentioned twenty-four patients), and of non-allergic controls, who had anti-BPO antibodies.
Plasmon-mediated patterning of nanoparticles and biomolecules for functional nano-devices (2018)

Nanoscale components are taking over the current generation devices in the semiconductor, biomedical, energy, and display industries. The translation of novel nanoparticles and biomolecules into practical applications depends on their precise patterning on a substrate. However, it has remained challenging to manufacture complex structures at sub-micrometer resolution due to inherent technological barriers, such as ink-spreading, and long post-processing time. This dissertation presents the progress made towards plasmon-mediated immobilization at scales ranging from single-nanoparticle regime up to large-area patterning. We exploit the photothermal and photochemical effects arising from hot spots of plasmonic nanoparticles for immobilization. We explore multi-photon plasmonic photolithography (MPPL) for patterning at single NP resolution and introduce laser-induced bubble printing to achieve large-area patterning. In addition, we also demonstrate simultaneous synthesis and structuring of nanoparticles and nanoalloys using a laser-mediated micro-bubble reactor. We demonstrate immobilization of multiple materials including bovine-serum albumin (BSA) hydrogels, quantum dots, silver nanorings, and immiscible bimetallic alloys. The fabricated structures are used in applications such as emission-rate modification, surface enhanced spectroscopy, ultra-fast nucleation, and catalysis. The systems and methods developed in this work will aid in the realization of multi-functional substrates with tailored catalytic, optical, electronic, and magnetic functions.
233. The analysis of mixtures of benzene-carboxylic acids by partition chromatography (1957)

B. Fishwick, J. Chem. Soc., 1957, 1196 DOI: 10.1039/JR9570001196
Structure-guided approach to site-specific fluorophore labeling of the lac repressor LacI (2018)

The lactose operon repressor protein LacI has long served as a paradigm of the bacterial transcription factors. However, the mechanisms whereby LacI rapidly locates its cognate binding site on the bacterial chromosome are still elusive. Single-molecule fluorescence imaging approaches are well suited for the study of these mechanisms but rely on a functionally compatible fluorescence labeling of LacI. Particularly attractive for protein fluorescence labeling are synthetic fluorophores due to their small size and favorable photophysical characteristics. Synthetic fluorophores are often conjugated to natively occurring cysteine residues using maleimide chemistry. For a site-specific and functionally compatible labeling with maleimide fluorophores, the target protein often needs to be redesigned to remove unwanted native cysteines and to introduce cysteines at locations better suited for fluorophore attachment. Biochemical screens can then be employed to probe for the functional activity of the redesigned protein both before and after dye labeling. Here, we report a mutagenesis-based redesign of LacI to enable a functionally compatible labeling with maleimide fluorophores. To provide an easily accessible labeling site in LacI, we introduced a single cysteine residue at position 28 in the DNA-binding headpiece of LacI and replaced two native cysteines with alanines where derivatization with bulky substituents is known to compromise the protein's activity. We find that the redesigned LacI retains a robust activity in vitro and in vivo, provided that the third native cysteine at position 281 is retained in LacI. In a total internal reflection microscopy assay, we observed individual Cy3-labeled LacI molecules bound to immobilized DNA harboring the cognate O1 operator sequence, indicating that the dye-labeled LacI is functionally active. We have thus been able to generate a functional fluorescently labeled LacI that can be used to unravel mechanistic details of LacI target search at the single molecule level.