gebhart/patrepeval huggingface dataset:
Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins (1998)

A new member of the gelsolin/villin family of actin regulatory proteins was initially identified by screening an adult murine brain cDNA library with a probe for bovine adseverin. The predicted amino acid sequence of the 92 kDa murine protein p92 (advillin) is 75% homologous to villin and 65% homologous to gelsolin and adseverin. It shares a six domain structure with other gelsolin family members and has a carboxy-terminal headpiece, similar to, yet distinct from, villin. Northern blot analysis shows a high level of mRNA expression in murine uterus and human intestine. In situ mRNA analysis of adult murine tissues demonstrates that the message is most highly expressed in the endometrium of the uterus, the intestinal lining, and at the surface of the tongue. In murine embryonic development, strong expression of the message is observed by day 14.5 in dorsal root ganglia and trigeminal ganglia. Expression is also noted at day 16.5 in cerebral cortex. We propose that p92 (advillin) has unique functions in the morphogenesis of neuronal cells which form ganglia, and that it may compensate to explain the near normal phenotype observed in villin-deficient mice.
Scheduling for Cellular Multicast: A Cross-Layer Perspective (2007)

Recent years have witnessed the importance of cross-layer design in wireless communication systems. The adoption of simplied on/off models for the wireless channel, in an attempt to reduce it to the traditional wireline case, has been shown to be highly sub-optimal. In this paper, we consider more realistic models for the wireless channel and demonstrate the signicant performance gains that can be leveraged from the wireless medium through intelligent scheduling strategies. We consider a cellular multicast channel, where a central base station transmits the same information stream to all the users within the system. We design scheduling algorithms for this scenario from a cross-layer perspective, which aids us in exploiting the characteristics of the wireless medium. We consider three classes of scheduling algorithms with progressively increasing complexity and study their asymptotic throughput-delay performance with the number of users in the system. The rst class strives for minimum complexity by resorting to static scheduling along with memoryless decoding. Our analysis reveals the existence of a scheduling scheme, within this class, that achieves near-optimal scaling laws of both delay and throughput. The second scheduling policy resorts to a higher complexity incremental redundancy encoding/decoding strategy to achieve a superior throughput-delay tradeoff. The third, and most complex, scheduling strategy benets from the cooperation between the different users and is shown to simultaneously achieve the optimal scaling laws of both delay and throughput. We further study the effect of equipping the base station with multiple transmit antennas on the throughput performance of the proposed low-complexity static schedulers. Finally, we present simulation results that validate our theoretical claims. I.
Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency Diseases (2007)

Hematopoietic stem cell transplantation (HSCT) is the only curative option for most children with severe combined immunodeficiency disease (SCID). Survival for SCID following HSCT has significantly improved over the past several decades, and ranges from 70% to 95% depending on the clinical condition of the child at the time of transplant, the availability of an HLA-matched sibling donor, and the SCID genotype/phenotype. In this article we will review the types of SCID and discuss the critical HSCT issues that confront us today, including the optimal source of donor cells when an HLA-matched sibling is not available, as well as the pros and cons of using conditioning therapy pretransplant. As SCID children have been followed for several decades, it is becoming apparent that long-term outcome and durable T and B cell immune reconstitution are quite variable depending on the initial treatment and source of donor cells. Finally, the development of methods to improve the early diagnosis of SCID along with designing prospective trials to evaluate the best approaches to curing these diseases with minimal toxicity are critical to improving outcomes for children with SCID.
A new Entry to Pyrazolo[4,3‐e][1,4]diazeoines. Facile Synthesis of Pyrazolo[4,3‐e][1,4]diazepin‐5,8‐diones, 5,6,7‐Triones and Pyrazolo[4,3‐e]pyrrolo‐[1,2‐a][1,4]diazepin‐5,10‐diones. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
α‐Substituierte Phosphonate. 39. Methandiphosphonsäureester durch UV‐induzierte Michaelis‐Becker‐Reaktion (1982)

α‐Substituted Phosphonates. 39. Methane‐diphosphonic Esters by U.V.‐Induced Michaelis‐Becker‐Reaction Dibromomethane resp. chlorbromomethane reacts with sodium dialkyl phosphite in heptane‐/liq.NH 3 or in liq. NH 3 by u.v. irradiation at low temperatures to give in good yields methane diphosphonic acid tetraalkylesters 1 . In the same manner with sodium diethyl thionophosphite the corresponding methane‐bis‐thiophosphonic acid tetraethylester 4 is obtained.
Formation of Stereoisomers of Beta-Carotene in Alfalfa (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of Stereoisomers of Beta-Carotene in AlfalfaC. R. Thompson, E. M. Bickoff, and W. D. MaclayCite this: Ind. Eng. Chem. 1951, 43, 1, 126–129Publication Date (Print):January 1, 1951Publication History Published online1 May 2002Published inissue 1 January 1951https://pubs.acs.org/doi/10.1021/ie50493a037https://doi.org/10.1021/ie50493a037research-articleACS PublicationsRequest reuse permissionsArticle Views17Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A selected bibliography of French reports in the field of aircraft icing (1953)

http://deepblue.lib.umich.edu/bitstream/2027.42/3917/5/bab4778.0001.001.pdf
Upper Midwest Freight Corridor Study (2005)

This study was undertaken in order to establish a regional approach to improving freight transportation through the Upper Midwest corridor. Improving freight flows through the region can improve reliability and enhance competitiveness. This study examines several aspects of regional freight transportation including, capacity, performance measures, administrative issues, demand/usage and best practices. The project was funded by six states in the region through their Departments of Transportation, and they have contributed to a pooled fund to finance the majority of the work. These states include Illinois, Indiana, Iowa, Minnesota, Ohio, and Wisconsin. Transportation modes addressed in the report include highways, railroads, water transportation and air transportation.
Organic Reactions in Ionic Liquids and on Supported Reagents (2002)

Chemistry in ionic liquids and on metal oxides, taken mostly from the authors own work, will be described. It willl be seen that ionic liquids compare favorably to metal oxide surfaces as reaction media and green phases.
Sulfur-nitrogen Heterocycles from the Condensation of Pyrazolones and 2-iminothiazolidin-4-ones with Phenyl Isothiocyanate (2007)

The condensation of 2-pyrazolin-5-ones with phenyl isothiocyanate, followed by reaction of the resulting thiolate ions with chloroacetyl chloride, phenacyl bromide, oxalyl chloride, 1,4-dibromo-2,3-butanedione and ethyl chloroformate, resulted in cyclisation to S,N-heterocycles in all cases. 2-Iminothiazolidin-4-ones, with phenyl isothiocyanate and then chloroacetyl chloride or phenacyl bromide, similarly formed 2,4′-bi(thiazolidine)-derived products.
Microstructural Effects on the Creep Deformation of Alumina/Single‐Wall Carbon Nanotubes Composites (2010)

The enhanced high‐temperature creep resistance in alumina/single‐wall carbon nanotubes (SWNTs) composites has been attributed to the unprecedented grain‐boundary structure of these composites, where the SWNTs bundles segregated at the alumina grain boundaries partially impede grain‐boundary sliding. In this study, the effect of SWNTs distributions at alumina grain boundaries on the creep behavior of alumina/SWNTs composites has been investigated. Microstructures of two different alumina/10 vol% SWNTs composites, one with heterogeneous and the other with homogenous distributions of SWNTs at grain boundaries, have been characterized quantitatively. The steady‐state creep rate (uniaxial compression) in the heterogeneous composite has been found to be over three times higher than that in the homogeneous composite at 1300° and 1350°C (argon atmosphere). It is argued that the less uniform distribution of SWNTs at the alumina grain boundaries in the heterogeneous composite results in less effective obstruction of grain‐boundary sliding, and attendant higher creep rate. This also results in more efficient recovery in that composite.
Quantitative analysis of ultrastructural components of nucleoli of the Walker tumor and liver. (1966)

Summary Nucleolar components were defined as fibrillar, granular or light areas on the basis of ultrastructural appearance. Quantitative measurements were made of these areas with the aid of a planimeter and the percentage of total nucleolar area composed of the various areas was determined. The highest content of fibrillar component was found in the nucleoli of the livers of actinomycin D-treated animals and the lowest was found in the Walker tumor. The Walker tumor nucleoli contained a number of regions that could be classified as fibrillogranular regions, but very few pure fibrillar regions were found. The finding that the percentage of the total nucleolar area composed of fibrillar regions was related in part to the adenylic acid + uridylic acid/guanylic acid + cytidylic acid ratio of nucleolar RNA supports previous suggestions that the fibrillar regions contain an RNA fraction richer in adenylic and guanylic acid.
Development of potential uses for the residue from fluidized bed combustion process (Minnick). Quarterly technical progress report, June--August 1978 (1978)

The conclusions based on the work done to date are: Wet chemical analysis of spent bed material from the Alliance boiler shows that this material exhibits the highest percentages of CaO and SO/sub 4/ of all FBC residue specimens that have been evaluated to date, together with the least amount of silica. The Battelle residue has the highest ignition loss of all spent bed material specimens analyzed thus far. Evaluation of pore volumes of residue indicates that the Alexandria residue possesses approximately three times the net pore volume of the Rivesville residue. (This observation may explain the high initial reactivity of the calcium oxide in the Alexandria residue in comparison to the Rivesville residue.) Blending of conditioned FBC residue and aggregate appears to be a more practical approach to the stockpiling of conditioned material for later use in stabilized road base applications than simply stockpiling the conditioned FBC residue alone. Testing of FBC residue and fly ash materials to be used in an upcoming road base demonstration in Ohio indicates that the physical properties of the mixtures are quite acceptable for this application. Proper blending of FBC residue and coal fly ash results in improved pellet production of synthetic aggregate compared to pellets made from FBC residue alone.
Geofences in the sky (2018)

Unmanned aerial vehicles (UAVs), typically also referred to as drones, are gaining popularity and becoming ubiquitous. As the number of drones in the sky rapidly grows, managing the expected high-volume air traffic is becoming a critical challenge. It is essential to prevent collisions, and to protect the public from nuisances like noise or invasion of privacy, and shield from hazards like falling debris. UAV traffic management should comply with regulation, spatiotemporal constraints and limitations of drones. Spatiotemporal constraints could be no-flight zones or areas where drone flight times are restricted. Drone limitations could refer to their speed, flight range, telecommunication capabilities, etc. Furthermore, managing air traffic for UAVs is very different from managing the traffic of self-driving ground vehicles. First, there are no clearly-marked roads in the sky. Second, some UAVs cannot hover and must have a cleared flight path. Third, air traffic should be managed in a 3-dimensional space. In this paper we present a vision of air-traffic control based on geofencing. We discuss three operation modes: centralized, decentralized and a hybrid of the two other modes. We present some of the challenges involved in drone traffic control and illustrate how geofencing could be a useful tool for that, while leveraging the emerging 5G networking technology.
Interleukin‐6 concentration changes in plasma and saliva in bisphosphonate‐related osteonecrosis of the jaws (2013)

Plasma and saliva IL-6 values were higher in our patients with BRONJ than in controls and therefore might be a useful tool for monitoring the severity of BRONJ.
Reactive plasma atomization of aluminum nitride powder (1997)

Experiments were performed to synthesize AlN powders by reacting Al with N using a conventional dc arc plasma as heat source. Feeding Al powder into Ar/N plasma open to atmosphere produced mainly Al oxide. Experiments using a chamber backfilled with nitrogen suppressed the Al oxide, but little AlN was formed. A furnace and crucible assembly was designed to feed molten Al directly into a DeLaval nozzle attached to the face of the dc arc plasma gun. Resulting submicron powders show a significant increase in AlN formation. This was dependent on chamber pressure, plasma velocity, and molten liquid feed rate. Experimental parameters, equipment design, effects of atomization/vaporization/condensation are discussed.
High-gain pulsed amplification of CW narrow bandwidth dye laser using 4-pass amplifier for high resolution spectroscopy (1996)

Using 4-pass dye amplifier pumped by a frequency doubled Nd:YAG laser, we obtained high peak power pulsed dye laser beam with good efficiency of 42% at total pumping power 77 mJ. The bandwidth of 120 MHz was measured.
PCB implementation techniques and evaluations for 10 Gbit/s high-speed signal transmission (2005)

Conventionally, inner layer wires using via holes that have large losses are not intended for high-speed electrical signal transmission in 10 Gbit/s printed-circuit boards (using the 7-GHz evaluation standard bandwidth), so only dedicated surface wires are used. However, surface wiring has a two-dimensional wiring layout and is not suited to high-density packaging. Therefore, to transmit high-speed signals by using inner layer wiring that allows high-density packaging, we designed and fabricated prototypes of extremely small via stub structures on a printed-circuit board by using a low-dielectric-constant and low-dielectric-tangent material and quantitatively evaluated the improvement in the transmission losses. Our results showed that the use of a low-dielectric-constant and low-dielectric-tangent material can double the transmission distance to 130 mm (from about 60 mm using FR-4 material). In addition, by using blind via holes and making the stubs as small as possible, via losses can be decreased by about 8 dB (for the 7-GHz band and with stub length reduced from 1.89 to 0.25 mm) compared to through-via holes. Based on this result, we demonstrated inner layer transmission of 10 Gbit/s signals in the board with high-density packaging. © 2005 Wiley Periodicals, Inc. Electron Comm Jpn Pt 2, 88(7): 39–49, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjb.20152
Corrosion fatigue life prediction for SUS 403 stainless steel in 3% NaCl aqueous solution. (1986)

In order to estimate the corrosion fatigue property of SUS 403 stainless steel, a corrosion fatigue test was performed under rotating bending in 3% NaCl aqueous solution at frequencies from 0.03 to 30 Hz up to ten thousand hours. Fatigue strength was monotonously decreased with increasing numbers of cycles and decreasing test frequency, except for the case of 30 Hz where fatigue limit was observed. The depth of corrosion pits at the origin of fatigue cracks was linearly correlated to the failure time on log-log coordinates. Microscopic observations revealed that the initiation of fatigue crack from a pit became possible when the growth rate of a hypothetical crack having the same depth as the pit exceeds the growth rate of the pit. Thus the corrosion fatigue life could be predicted from the crack initiation period and propagation period.
Optimum confining effect in steel composite hollow RC column with inner tube under compressive load (2014)

An internally confined hollow reinforced concrete (ICH RC) column offers strong and durable confinement by the reinforcement of the inner tube. When the concrete in an ICH RC column experiences axial pressure, an inward radial pressure is produced by the arching action. This radial pressure is resisted by the concrete and the inner tube. Previous research considered the outer pressure and inner pressure to be equal. However, the inner pressure acting on the inner tube is lower because it is partially resisted by the concrete. Therefore, to determine the optimum confining effect on the concrete by the confining condition, it was necessary to determine reasonable values for the inward and outward confining stress in ICH RC columns. In the current study, the confining effects of concrete in an ICH RC column were investigated and evaluated using finite-element (FE) analysis. Parametric studies were performed to determine the factors affecting the confinement of the core concrete in an ICH RC column. The hollow ratio was found to be the main factor affecting the internal confining stress in an ICH RC column. Using the results of FE analysis, estimation equations for the internal confining stress and a new modified equation for the failure condition were developed.
Inactivation of the 7B2 inhibitory CT peptide depends on a functional furin cleavage site (2001)

The eukaryotic subtilisin prohormone convertase 2 (PC2) is known to require in vivo exposure to the neuroendocrine protein 7B2 in order to produce an enzymatically active species capable of proteolytic action on prohormone substrates. In the present study, we examined the role of the pentabasic site within 27‐kDa 7B2 in this process. We prepared two His‐tagged recombinant 7B2s by overexpression in bacteria: 7B2‐Ser‐Ser (SS), with an inactivating mutation in the CT peptide from Lys171‐Lys172 (KK) to SS, rendering the CT peptide non‐inhibitory; blockade‐SS, a double mutant of both the CT peptide as well as of the pentabasic furin cleavage site. These purified proteins were used in a cell‐free proPC2 activation assay. Both 7B2‐SS as well as blockade‐SS were able to facilitate the activation of proPC2 (as judged by efficient production of enzyme activity), suggesting that cleavage at the furin site is not required for 7B2s lacking inhibitory CT peptides. Plasmids encoding proPC2 and various 7B2s were transiently transfected into human embryonic kidney (HEK293) cells and PC2 enzymatic activity and CT forms in each overnight conditioned medium were measured. Cells transfected with proPC2 and wild‐type 7B2 secreted CT peptide cleavage products, but cells transfected with proPC2 and the blockade mutant overwhelmingly secreted intact, 27‐kDa, blockaded 7B2. Medium obtained from HEK293 cells transfected with proPC2 and either wild‐type 7B2, 7B2‐SS, or blockade‐SS exhibited PC2 activity, but medium from cells expressing the 7B2 blockade mutant did not. We conclude that cleavage at the 7B2 furin consensus site is required to produce PC2 capable of efficient proteolytic inactivation of the CT peptide.
A concept for a soft gamma-ray concentrator using thin-film multilayer structures (2016)

We are investigating the use of thin-film, multilayer structures to form optics capable of concentrating soft gamma rays with energies greater than 100 keV, beyond the reach of current grazing-incidence hard X-ray mirrors. Alternating layers of low- and high-density materials (e.g., polymers and metals) will channel soft gamma-ray photons via total external reflection. A suitable arrangement of bent structures will then concentrate the incident radiation to a point. Gamma-ray optics made in this way offer the potential for soft gamma-ray telescopes with focal lengths of less than 10 m, removing the need for formation flying spacecraft and opening the field up to balloon-borne instruments. Following initial investigations conducted at Los Alamos National Laboratory, we have constructed and tested a prototype structure using spin coating combined with magnetron sputtering. We are now investigating whether it is possible to grow such flexible multi-layer structures with the required thicknesses and smoothness more quickly by using magnetron sputter and pulsed laser deposition techniques. We present the latest results of our fabrication and gamma-ray channeling tests, and describe our modeling of the sensitivity of potential concentrator-based telescope designs. If successful, this technology offers the potential for transformational increases in sensitivity while dramatically improving the system-level performance of future high-energy astronomy missions through reduced mass and complexity.
Involvement of Superoxide Generation in Salicylic Acid-Induced Stomatal Closure in Vicia faba (2001)

Salicylic acid (SA), the known mediator of systemic acquired resistance, induced stomatal closure of Vicia faba L. Application of SA to the epidermal peels evoked an elevation of chemiluminescence of Cripridina lucigenin-derived chemiluminescent reagent (CLA) which is sensitive to superoxide anion (O(2)(.-)). The SA-induced generation of chemiluminescence was suppressed by O(2)(.-)-specific scavengers superoxide dismutase (SOD) and 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron). These results suggest that O(2)(.-) was generated in epidermal peels by SA-treatment. A peroxidase inhibitor salicylhydroxamic acid (SHAM) inhibited guaiacol peroxidase activity and suppressed the SA-induced CLA chemiluminescence in the epidermal peels, suggesting that O(2)(.-) generation occurred by the peroxidase-catalyzed reaction as proposed for SA-treated tobacco cell suspension culture [Kawano et al. (1998) Plant Cell Physiol. 39: 721]. SOD, Tiron or SHAM suppressed the SA-induced stomatal closure. Moreover, application of superoxide-generating system also induced stomatal closure. These results support the concept of involvement of reactive oxygen species in signal transduction in SA-induced stomatal closure.