gebhart/patrepeval huggingface dataset:
Structural and Dynamic Analysis of Residual Dipolar Coupling Data for Proteins (2001)

The measurement of residual dipolar couplings in weakly aligned proteins can potentially provide unique information on their structure and dynamics in the solution state. The challenge is to extract the information of interest from the measurements, which normally reflect a convolution of the structural and dynamic properties. We discuss here a formalism which allows a first order separation of their effects, and thus, a simultaneous extraction of structural and motional parameters from residual dipolar coupling data. We introduce some terminology, namely a generalized degree of order, which is necessary for a meaningful discussion of the effects of motion on residual dipolar coupling measurements. We also illustrate this new methodology using an extensive set of residual dipolar coupling measurements made on (15)N,(13)C-labeled human ubiquitin solvated in a dilute bicelle solution. Our results support a solution structure of ubiquitin which on average agrees well with the X-ray structure (Vijay-Kumar, et al., J. Mol. Biol. 1987, 194, 531--544) for the protein core. However, the data are also consistent with a dynamic model of ubiquitin, exhibiting variable amplitudes, and anisotropy, of internal motions. This work suggests the possibility of primary use of residual dipolar couplings in characterizing both structure and anisotropic internal motions of proteins in the solution state.
Efficient Estimation and Pilot-Free Online Re-Calibration of $I/Q$ Imbalance in Broadband Direct-Conversion Transmitters (2014)

This paper proposes an efficient estimation and pilot-free online re-calibration scheme for frequency-selective I/Q imbalance in broadband direct-conversion transmitters (Txs) with multi-band multi-standard capability. For such Txs, the main challenge lies in the online re-calibration during normal operation, where an ordinary Tx signal, instead of dedicated pilot signals, is used for estimation. In particular, it can happen that the Tx signal consists of noncontiguous subbands and has large spectral gaps, which will cause a severe ill-conditioned matrix problem in existing state-of-the-art (SoA) schemes deploying least squares (LS) estimation. In the proposed scheme, this problem is avoided by exploiting the fact that the frequency-selective part of I/Q imbalance is approximately time invariant. Therefore, before normal operation, pilot-based initial estimation is carried out to achieve high-precision estimation of the frequency-selective part. Afterward, pilot-free online re-calibration is applied to cope with the time-varying frequency-independent part. Both theoretical analysis and numerical simulations show that the proposed re-calibration scheme is well conditioned and clearly outperforms the existing SoA schemes deploying LSE. To emphasize practical deployments, we also conduct performance analysis considering time synchronization error (TSE) and provide a Toeplitz-extension-based solution to make the scheme robust against TSE. We further provide complexity analysis and show that the proposed scheme has much lower complexity than the SoA schemes. Finally, the performance of the proposed scheme and the fundamental working assumptions are verified by both numerical simulations and hardware-in-the-loop (HIL) experiments with real radio-frequency signal measurements, including real-time field-programmable gate-array (FPGA) implementation of the developed digital calibration circuits.
Vasoproliferation in the neonatal dog model of oxygen-induced retinopathy. (1996)

This study demonstrates that in the neonatal dog, revascularization after hyperoxic insult involves a period of marked vasoproliferation that peaks somewhere between 3 to 10 days after return to room air. Oxygen-induced changes in the extravascular milieu are likely to affect the pattern of reforming vasculature and may restrict growth anteriorly.
Moiré analysis of the reconstruction accuracy and uniformity of holograms (1986)

A moiré technique for the analysis of the reconstruction accuracy and uniformity of holograms is presented. A Ronchi ruling is recorded holographically, and the image is cast on the object ruling. The superposition of the two rulings forms a moiré pattern that serves for the evaluation of the holograms. Reconstruction accuracies of 0.05% could be monitored throughout the whole field. This moiré pattern may also be applied for studying phase objects.
Effects of the Antipsychotic Drug Sulpiride on Reproductive Hormones in Healthy Men: Relationship with Body Weight Regulation (1997)

Metabolic and endocrine abnormalities secondary to hyperprolactinemia, particularly hypogonadism, may be involved in the excessive body weight gain observed during treatment with antipsychotic drugs. The present study was conducted in healthy men in order to detect an endocrine imbalance secondary to antipsychotic drug administration, which, if sustained in the long term, might be involved in the development of obesity. Sulpiride (200 mg daily for 30 days) or placebo was nonblindly administered, and body weight gain was correlated with the serum levels of prolactin, luteinizing hormone, follicle-stimulating hormone, estradiol, free testosterone, thyrotropic hormone, free tetraiodothyroxine, cortisol, dehydroepiandrosterone sulphate (DHEA-S), and the ratios estradiol/testosterone and testosterone/DHEA-S; the blood lipids were also assessed. Body weight gain and the serum levels of prolactin were significantly increased by sulpiride; in addition, a significant positive correlation was observed between prolactin levels and body weight gain. Other endocrine parameters were not significantly affected by the drug. These short-term results show that in healthy men, body weight can be increased by antipsychotic drug administration; this effect may be related to hyperprolactinemia alone, since other endocrine parameters were normal at the time of treatment. A more prolonged treatment with antipsychotic agents might be required to observe the alterations in gonadal and adrenal steroids often detected in subjects with primary obesity.
An End-Milling Condition Decision Support System Using Data-Mining for Difficult-to-Cut Materials (2012)

We proposed the data-mining methods using hierarchical and non-hierarchical clustering methods to help engineers decide appropriate end-milling conditions. The aim of our research is to construct a system that uses clustering techniques and tool catalog data to support the decision of end-milling conditions for difficult-to-cut materials. We used variable cluster analysis and the K-means method to find tool shape parameters that had a linear relationship with the end-milling conditions listed in the catalog. We used the response surface method and significant tool shape parameters obtained by clustering to derive end-milling condition. Milling experiments using a square end mill under two sets of end-milling conditions (conditions derived from the end-milling condition decision support system and conditions suggested by expert engineers) for difficult-to-cut materials (austenite stainless steel) showed that catalog mining can be used to derive guidelines for deciding end-milling conditions.
Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase (2013)

Ltn1 is a 180-kDa E3 ubiquitin ligase that associates with ribosomes and marks certain aberrant, translationally arrested nascent polypeptide chains for proteasomal degradation. In addition to its evolutionarily conserved large size, Ltn1 is characterized by the presence of a conserved N terminus, HEAT/ARM repeats predicted to comprise the majority of the protein, and a C-terminal catalytic RING domain, although the protein's exact structure is unknown. We used numerous single-particle EM strategies to characterize Ltn1's structure based on negative stain and vitreous ice data. Two-dimensional classifications and subsequent 3D reconstructions of electron density maps show that Ltn1 has an elongated form and presents a continuum of conformational states about two flexible hinge regions, whereas its overall architecture is reminiscent of multisubunit cullin-RING ubiquitin ligase complexes. We propose a model of Ltn1 function based on its conformational variability and flexibility that describes how these features may play a role in cotranslational protein quality control.
Low noise electro-optic comb generation by fully stabilizing to a mode-locked fiber comb (2016)

A fully stabilized EO comb is demonstrated by phase locking the two degrees of freedom of an EO comb to a low noise mode-locked fiber comb. Division/magnification of residual phase noise of locked beats is observed by measuring an out-of-loop beat. By phase locking the 200 th harmonics of the EO comb and a driving cw frequency to a fiber comb, a record low phase noise EO comb across +/- 200 harmonics (from 1544.8 nm to 1577.3 nm) is demonstrated.
Successful treatment with infliximab and methotrexate of pyostomatitis vegetans associated with Crohn's disease (2003)

A 35-year-old woman with severe fistulizing Crohn's disease presented with pyostomatitis vegetans affecting both the mouth and the vulva. The coalescing pustules transformed within several days into vegetating lesions on areas of inflammation. Microbial assessments revealed no pathogenic agent. Histology showed neutrophilic microabscesses, but no granulomas. Three injections of infliximab and maintenance therapy with methotrexate resulted in rapid and complete regression of both the pyostomatitis vegetans and the Crohn's disease. Infliximab and methotrexate may be a promising treatment for the rare cases of pyostomatitis vegetans associated with Crohn's disease.
Carving differential unit test cases from system test cases (2006)

Unit test cases are focused and efficient. System tests are effective at exercising complex usage patterns. Differential unit tests (DUT) are a hybrid of unit and system tests. They are generated by carving the system components, while executing a system test case, that influence the behavior of the target unit, and then re-assembling those components so that the unit can be exercised as it was by the system test. We conjecture that DUTs retain some of the advantages of unit tests, can be automatically and inexpensively generated, and have the potential for revealing faults related to intricate system executions. In this paper we present a framework for automatically carving and replaying DUTs that accounts for a wide-variety of strategies, we implement an instance of the framework with several techniques to mitigate test cost and enhance flexibility, and we empirically assess the efficacy of carving and replaying DUTs.
Synthesis and Microbial Inhibition Study of Novel 5‐Imidazolyl Substituted Isoxazolidines. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
[Acute diaphragmatic lesions due to closed thoracic-abdominal trauma]. (1992)

Diaphragmatic injuries due to blunt trauma are steadily related to a high mortality. Their diagnosis may be difficult, due to the lack of specific symptoms and, more frequently to the high incidence of coexisting lesions which can mask the clinical appearance. This work presents the main aspects of ten cases admitted to the Emergency Surgery Division of Cagliari (USL 21), during the last seven years, with a review of the literature.
Experimental Validation of CFD Modeling for Narrow Tillage Tool Draft (2007)

Total energy requirement of a vertical narrow tool is a function of different soil-tool interaction components like soil parameters, tool parameters and system parameters. Dynamic analysis of tillage-tool modeling concerns soil deformation due to soil shear failure caused by mainly soil-soil interaction, soil-tool interaction and acceleration energy. Soil bin tests were conducted to validate tool draft predictions from numerical modeling using computational fluid dynamics (CFD). Three dimensional simulations were carried out using fluid dynamics approach considering soil as a Bingham material. Soil dynamic parameters such as soil viscosity and yield stress were determined by a strain rate controlled torsional Soil Rheometer, developed in the Agricultural and Bioresource Engineering Department, University of Saskatchewan. Numerical predictions of tool draft were observed with 40 mm wide vertical tool operating at four different depths of 40, 80, 120, and 160 mm. The tool was operated at four different operating speeds of 1, 8, 16 and 24 km h-1 in clay loam soil with two moisture contents of 14 and 20%. Soil bin experiments were conducted with the same tool configurations, soil conditions and operating speed. Draft values predicted by the CFD modeling were highly correlated with those obtained from soil bin experiment.
Illuminations: An Interview with Andrew Noren (1991)

Research Article| April 01 1991 Illuminations: An Interview with Andrew Noren Scott MacDonald, Scott MacDonald Search for other works by this author on: This Site PubMed Google Scholar Andrew Noren Andrew Noren Search for other works by this author on: This Site PubMed Google Scholar Film Quarterly (1991) 44 (3): 30–43. https://doi.org/10.2307/1212794 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Scott MacDonald, Andrew Noren; Illuminations: An Interview with Andrew Noren. Film Quarterly 1 April 1991; 44 (3): 30–43. doi: https://doi.org/10.2307/1212794 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentFilm Quarterly Search This content is only available via PDF. Copyright 1991 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
Quantitative Evaluation of Wind Turbine Faults Under Variable Operational Conditions (2016)

Wind turbines have been widely used for clean and renewable electricity generation. The maintenance costs of wind turbines constitute a significant portion of the total cost of the generated electricity. Thus, health management systems are increasingly needed to reduce the maintenance costs and improve the reliability of wind turbines. This paper proposes a novel framework for the quantitative evaluation of faults and health conditions of wind turbines using generator current signals. A synchronous resampling algorithm is designed to handle nonstationary current signals for fault feature extraction. The extracted fault features are used to reconstruct new signals, whose correlation dimensions are then calculated by using the Grassberger-Procaccia (G-P) algorithm for fault and health condition evaluation of the wind turbines. Experimental studies are carried out for a direct-drive wind turbine equipped with a permanent-magnet synchronous generator (PMSG) in the healthy condition and two faulty conditions. Results show that the proposed framework can not only detect the faults but also quantify different health conditions for the wind turbine.
ChemInform Abstract: New Ligands for Asymmetric Palladium Catalyzed Allylic Substitution Reactions. X‐Ray Crystal Structures of Two Enantiomerically Pure Dihydrobenzazaphosphole‐Borane Complexes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Improved digital TV encoding and decoding system (1967)

Analog-to-digital coder and digital-to-analog decoder system handles wideband TV signals. The system incorporates solid state plug-in modular units and is operated in a VSD /Variable Slope Delta Modulation/ mode or in the conventional one-bit DM /Delta Modulation/ mode.
Efficient forwarding and popularity based caching for Content Centric Network (2015)

In Content Centric Network, caching and forwarding schemes can affect the performance of the whole network. The original caching and forwarding schemes are simple, but these schemes have some drawbacks. Firstly, the original caching scheme stores the same content on several neighboring routers along the request path. This redundant caching does not use the limited storage space available to the routers efficiently. Secondly, the original forwarding scheme in which the data requests are flooded to neighboring routers, also degrades the performance of the network. In this paper, we aim to solve the issues of using cache space of each router efficiently and forwarding the data requests effectively. In this proposal, we divided an Autonomous System (AS) in several groups of routers to cache the popular contents. Routers in a group cooperatively store the data and forward the Interest in order to increase the network performance. To improve the cache hit, the group of routers only store the popular contents and reduce the duplicate content without effecting the redundancy. We used Consistent Hashing to reduce overlapping contents and forward the request efficiently. The content popularity prediction algorithm assists the routers to store the popular contents that pass through them. Finally, we evaluated the performance of our proposed scheme by using a chunk level simulator.
Numerical Modeling of Complex Fluids: State-of-the-Art, Recent Developments and New Challenges (2006)

International audience
Low-Volume Pumping Systems: Moving Gallons to Produce Thousands (2008)

Abstract In recent times, a continuous fiberglass rod pumping system has been designed for producing low volumes of fluid from gas wells that are loaded up with water. This system utilizes an efficient, low horsepower pumping unit, which operates on a ½ horsepower, solar powered DC electric motor. A conventional insert type rod pump is utilized so that pump changes do not require a work over rig, only the use of a spool trailer. Other than using solar power this system is installed in two other configurations: 1) Hybrid – using available electricity and 2) Just the continuous fiberglass rod under a conventional beam pumping unit. In any configuration the goal is to minimize friction losses, so a small motor can power the system. Small diameter plunger limits both the fluid load lifted by the rods and limits the amount of fluid volume that can be produced to the surface, but only a few barrels per day of water can lead to liquid loading and killing flow from a gas well. Dynamometer and fluid level measurements will be presented to show the performance of several of the existing systems – Solar and Hybrid. Depth limitations for the ½″ diameter fiberglass rod will be discussed. Small diameter pump, small pumping unit size and light weight continuous rods allow the operator to use less than 1 hp motor to power the system.
<title>Influence of annealing on the morphology and phase composition of plasma-sprayed Ni/Al coatings</title> (1999)

Thermal annealing of plasma sprayed Ni/Al coatings used as the catalyst was investigated. The coatings were plasma sprayed on Cu substrate at low vacuum conditions (approximately 1 Pa) and were heated at temperatures of 600 degree(s)C and 800 degree(s)C in Ar atmosphere for 5 hours. Scanning electron microscopy and X-ray diffraction were used to study influence of annealing on the morphology and phase transformation in the Ni/Al coatings. A change of morphology of the coatings to smoother and less porous during thermal treatment was observed. Grain size number changes from n equals 5.52 for annealed coatings to n equals 5.37 and n equals 5.26 for coatings annealed at 600 degree(s)C and 800 degree(s)C, respectively. At the same time phase transformation with appearance of new alloys took place. These changes greatly influence other properties of the Ni/Al coatings.
The International LAM Registry: A Component of an Innovative Web-Based Clinician, Researcher, and Patient-Driven Rare Disease Research Platform (2010)

Collaboration between clinicians, researchers, advocacy groups, and patients can create essential community resource infrastructure to accelerate rare disease research. The International LAM Registry is an example of such an effort. 82.
The Metabolic Fate of α-Sulphobenzylpenicillin in Rats (1972)

1. After intramuscular injection of a new semi-synthetic penicillin, disodium [14C]α-sulphobenzylpenicillin, to rats radioactivity in blood reached a peak at 5 min with a half life of 26 min. Most of the blood radioactivity was not bound to plasma protein and 70% was accounted for as the intact penicillin.2. At 20 min after dosage the radioactivity was distributed mostly in liver, kidney, intestinal contents and blood. About half of the injected radioactivity was excreted into the urine within 8 h. Faecal excretion was much slower but continued for longer duration and amounted to 24% after 3 days.3. In bile-duct cannulated rats, 35% of the dosed radioactivity was excreted into bile and 52% into urine within 24 h.4. In both urine and bile, 50 to 85% of the radioactivity was present as unchanged drug and 10 to 20% as its penicilloic acid.5. Intravenous injection gave similar metabolic patterns as those observed after intramuscular injection except that faecal excretion was increased.6. Autoradiographic studies on mice were similar to findings on the tissue distribution study for the rat.
Multicarrier generator using a phase modulated laser signal and tailored chirped fiber Bragg gratings (2007)

A phase modulated spectrum is flattened with apodized chirped fiber Bragg gratings. Multicarrier generation with 7 frequencies is achieved with less than 2 dB peak-to-peak variation and 40 dB signal-to-noise ratio.
Surface relaxation in liquid water and methanol studied by x-ray absorption spectroscopy (2002)

X-ray absorption spectroscopy is a powerful probe of local electronic structure in disordered media. By employing extended x-ray absorption fine structure spectroscopy of liquid microjets, the intermolecular O–O distance has been observed to undergo a 5.9% expansion at the liquid water interface, in contrast to liquid methanol for which there is a 4.6% surface contraction. Despite the similar properties of liquid water and methanol (e.g., abnormal heats of vaporization, boiling points, dipole moments, etc.), this result implies dramatic differences in the surface hydrogen bond structure, which is evidenced by the difference in surface tension of these liquids. This result is consistent with surface vibrational spectroscopy, which indicates both stronger hydrogen bonding and polar ordering at the methanol surface as a consequence of “hydrophobic packing” of the methyl group.