gebhart/patrepeval huggingface dataset:
Selective Stabilization of Triplex DNA by Poly(ethylene glycols) (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective Stabilization of Triplex DNA by Poly(ethylene glycols)C. H. Spink and J. B. ChairesCite this: J. Am. Chem. Soc. 1995, 117, 51, 12887–12888Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ja00156a038https://doi.org/10.1021/ja00156a038research-articleACS PublicationsRequest reuse permissionsArticle Views424Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Perforation and Intravesical Erosion of a Ventriculoperitoneal Shunt in a Child with an Augmentation Cystoplasty (1992)

Bladder augmentation has evolved into a common method of management in children with a low capacity and/or poorly compliant bladder secondary to a neuropathic condition. We report on a 4-year-old girl with myelodysplasia who presented with sepsis and who had a perforation of the augmented bladder, which was surgically repaired. She returned for evaluation 1 month after she was discharged from the hospital when the distal component of the ventriculoperitoneal shunt was noted to protrude per urethram after clean catheterization. Distal shunt replacement with prolonged bladder drainage successfully resolved this perforation of the augmented bladder. The patient has had no further difficulties. We discuss the diagnosis and management of this case with reference to the current literature regarding complications of augmentation cystoplasty.
High glucose via NOX-dependent ROS generation and AKT activity promotes adipose-derived stem cell de-differentiation (2012)

NADPH-oxidase (NOX)-dependent reactive oxygen species (ROS) production is involved in self-renewal of stem and progenitor cells. Herein, we investigated whether high glucose (25 mM/L) (HG)-dependent NOX-mediated ROS generation is involved in self-renewal of visceral adipose tissue-derived stem cells (ASCs) as well. To this end ASCs cultured in HG or normal glucose (5 mM/L) used as control, were evaluated for their stem cell identity. We demonstrated that freshly isolated ASCs are pluripotent as they differentiate into adipocytes in-vitro and form neovessels in-vivo. However, only HG-cultured ASCs expressed octamer-binding transcription factor 4 (Oct4) and Nanog and formed spheroids. The assembly of p47phox and p67phox subunits is crucial for NOX-enzymatic activity. By knock-down of p47phox the role of NOX-generated ROS in driving ASC de-differentiation has been provided. siRNA technology was also applied to demonstrate the role of Akt activity in mediating HG-induced Oct-4 and Nanog expression as well as spheroid formation. Additionally, by knock-down of Oct4 we provided further evidence that Oct4 is essential for HG-mediated stem cell identity. Soluble factors released by ASCs are key elements in their mechanism of action. We found that NOX and Akt activity are required for cytokine production by "spheroids". Finally, as HG-cultured ASCs, diabetic patient-derived ASCs expressed higher levels of Oct-4 and Nanog than ASCs derived from healthy subjects and engaged ROS and Akt activity to turn on their secretion program. Thereby, our data indicate that HG via NOX-dependent Akt activity induces ASC de-differentiation, and suggest that HG pre-conditioning might be exploited for ASC ex-vivo expansion.
The Fenton oxidation mechanism: reactivities of biologically relevant substrates with two oxidizing intermediates differ from those predicted for the hydroxyl radical. (1994)

The application of kinetic probes that allow one to determine relative reactivities of biologically relevant substrates with oxidizing intermediates in the Fenton reagent (H2O2 plus Fe2+ in acidic aqueous solution) is described. These results lead to the conclusion that there are two key intermediates with very different reactivity patterns. One (X) is proposed to be an iron complex formed via direct reaction of H2O2 with Fe2+, which reacts with N-nitrosodimethylamine to generate a strong transient absorption at 450 nm. This provides a sensitive spectrophotometric probe of the competitive reactivities toward X of biologically relevant substrates such as nucleic acid components and amino acids. The second intermediate (Y) is probed by its oxidation of the Ru(bpy)2+3 ion (bpy = 2,2'-bipyridine) to a product with an absorption band centered at 500 nm. In the absence of other substrates, Ru(bpy)2+3 is oxidized at rates independent of the Ru concentration, but the product yield is diminished by competing reactions with substrates that can intercept X. Competition studies demonstrate reactivity patterns for X and Y that are clearly distinct from the pattern predicted for the hydroxyl radical, the intermediate commonly invoked in discussions of Fenton oxidations. These data require reevaluation of the mechanisms by which the Fenton reagent oxidizes biological substrates.
Efficient organization of large ship radar databases using wavelets and structured vector quantization (2002)

We investigate the problem of efficient representations of large databases of pulsed radar returns from naval vessels in order to economize memory and minimize search time. We use synthetic radar returns from ships as the experimental data. The results extend to real ISAR returns. We develop a novel algorithm for organizing the database, which utilizes a multiresolution wavelet representation working in synergy with a tree structured vector quantizer (TSVQ), utilized in its clustering mode. The tree structure is induced by the multiresolution decomposition of the pulses. The TSVQ design algorithm is of the "greedy" type. Our experiments to date indicate that the combined algorithm results in orders of magnitude faster data search time, with negligible performance degradation from the full search vector quantization. The combined algorithm provides an efficient indexing scheme (with respect to variations in aspect, elevation and pulsewidth) for radar data which can facilitate the development ATR, surveillance and multi-sensor fusion systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electrochemical Oxygen Removal from Seawater in Industrial Scale Using Silver Cathode (2017)

In this study, electrochemical removal of oxygen from seawater in industrial scale is demonstrated. A test rig with an industrial scale electrochemical cell has been constructed and tested with filtrated oxygen rich seawater. The electrochemical cell was comprised of a silver mesh cathode and an iridium oxide anode with a cation exchange membrane. The effects of flow rate, pressure, and applied voltage on oxygen removal efficiency and resulting current were studied. Also, the differential pressure between the anode and cathode chambers affected the performance of the cell, and an overpressure of 0.20–0.30 bar in the anode chamber was optimal in order to obtain maximum oxygen removal. It was possible to achieve an oxygen concentration lower than 5 ppb in seawater at a flow rate of 5 L min–1. No scaling or biofilm problems were observed during a 200 h test period.
Crown ether modified peptide interactions with model membranes<sup>‡</sup> (2019)

A simple model of an uncharged antimicrobial peptide, carrying four crown ether side chains, is modified further by the selective incorporation of arginine side chains to control its secondary structure and its interaction with model membranes and living cells. Conformational studies show that shifting the position of a cationic residue in the peptide sequence allows to control its secondary structure and supramolecular self-assembly in solution. Results also demonstrate that the secondary structure influences the interaction with model membranes and cells. An α-helical peptide with greater amphiphilicity forms assemblies that interact with both prokaryotic and eukaryotic model membranes and cells. However, a β-stranded peptide with evenly distributed charges generates assemblies that interact more selectively with prokaryotic model membranes and cells. In addition, we observed differences in peptide orientation between uncharged and cationic α-helical peptides with different phospholipid bilayers. In general, the studied peptides have a higher affinity for thinner membranes, and cationic peptides interacted better with anionic membranes.
Distributed System Design with Message Sequence Charts (2000)

The methodical mastery of interaction scenarios is a key factor for capturing and modeling system requirements of distributed, reactive systems. Message Sequence Charts (MSCs) and variants thereof are well-accepted as a graphical description technique for interaction scenarios. MSCs emphasize the inter-component coordination aspect of typically partial system executions; this complements the usually complete behavior description for individual components, as given by state-oriented automaton specifications. The topic of this thesis is the seamless, methodically founded integration of MSCs into the development process for distributed, reactive systems. The comparison of several MSC dialects and automaton models is followed by the definition and analysis of the formal syntax and semantics for the MSC notation used in this thesis. The stream-based system model, underlying the semantics definition, enables the integrated consideration of interaction-oriented and state-oriented system specifications; it also serves as the basis for the introduction of effective refinement notions for MSCs. Next, different MSC interpretations -- in the range from scenario specification to complete behavior descriptions to the specification of unwanted behavior -- are formally defined. In addition, the application of MSCs for the description of safety and liveness properties is analyzed. Finally, two transformation procedures, supporting the transition from interaction scenarios to complete behavior specifications for individual components, are presented. The first one schematically extracts relational assumption/commitment specifications from MSCs. The second one turns MSCs syntactically into corresponding state automata. On the one hand this makes the component properties defined by MSCs accessible to formal analysis; on the other hand this constructively bridges the gap between interaction requirements and component implementations.
Aspects of risk management support for an Emergency Medicine Physician Workstation. (1994)

Emergency departments are high risk sites for malpractice events. EMstation™ is an Emergency Medicine Physician Workstation that incorporates tools to reduce malpractice risk in near real time (at the time of documentation). Based on a Microsoft Windows 3.1 interface, physicians are led through color-coded templates addressing known failure modes in emergency medicine. Risk management opportunities available at the time of charting when the patient is often still in the department allowing real time risk reduction are explored.
Periprosthetic joint infection: current concepts and outlook (2019)

Periprosthetic joint infection (PJI) is a serious complication occurring in 1% to 2% of primary arthroplasties, which is associated with high morbidity and need for complex interdisciplinary treatment strategies.The challenge in the management of PJI is the persistence of micro-organisms on the implant surface in the form of biofilm. Understanding this ability, the phases of biofilm formation, antimicrobial susceptibility and the limitations of host local immune response allows an individual choice of the most suitable treatment.By using diagnostic methods for biofilm detection such as sonication, the sensitivity for diagnosing PJI is increasing, especially in chronic infections caused by low-virulence pathogens.The use of biofilm-active antibiotics enables eradication of micro-organisms in the presence of a foreign body. The total duration of antibiotic treatment following revision surgery should not exceed 12 weeks. Cite this article: <i>EFORT Open Rev</i> 2019;4:482-494. DOI: 10.1302/2058-5241.4.180092.
pH near Cells on Stainless Steel and Titanium (2004)

Murine fibroblast L929 cells were cultured for 605 ks on 316L stainless steel and titanium specimens and a cell adhesive layer was formed. Tip of a tungsten microelectrode was placed at the intracell layer and a few millimeters above the cell layer, and pH values of the intra- and extracell layer were measured, respectively. The pH values of the intracell layer on metallic specimens were apparently lower than that of the extracell layer. Therefore, the pH on metallic materials decreases with cells, that is probably caused by corrosion reaction as well as chemicals generated by cells. © 2004 The Electrochemical Society. All rights reserved.
The search for disease modification in moderate to severe Alzheimer disease (2005)

It is currently estimated that 50% of patients with Alzheimer disease (AD) suffer from moderate to severe disease.1 After diagnosis, the severity of AD can be staged by assessing cognition (using the Mini-Mental State Examination [MMSE]) or function (i.e., activities of daily living [ADL]), as well as global clinical impressions (using either the Clinical Dementia Rating [CDR] Scale or the Global Deterioration Scale [GDS]).2–5 Typically, moderate to severe AD patients have an MMSE score of ≤17, loss of many instrumental ADL, a CDR score of ≥2, and a GDS score of ≥5.3,5,6 The progression from mild to moderate to severe AD is also associated with significant loss of independence, with increasing attention needed from caregivers and family members, as well as various behavioral changes that include social withdrawal, misidentification of family members, and increasing agitation.7

Depending on the stage of illness, patients with AD exhibit various degrees of structural and pathologic changes. At a more basic level, CT and MRI of the brain reveal atrophy in mild stage patients that may be localized primarily to the hippocampal regions, whereas atrophy in moderate to severe stage patients becomes more generalized. More specifically, senile plaques containing β-amyloid (Aβ) proteins and neurofibrillary tangles composed of abnormally phosphorylated tau protein become more generalized throughout the cortex in moderate to severe AD.8

Pathophysiologic changes in moderate to severe AD involve significant loss of function in several different neurotransmitter systems. For example, in the cholinergic neurotransmitter systems, markers of cholinergic functioning may be normal in milder stages, with significant losses becoming prominent only in moderate to severe disease.9 Deficits or abnormal functioning in the dopaminergic, serotonergic, and particularly the glutaminergic neurotransmitter systems, also become more prominent in the later stages of AD. These increasing deficits in neurotransmission are viable targets …
Influence of Washing on Zirconia Powder for Electrophoretic Deposition (2001)

The effects of powder washing on the colloidal stability and electrophoretic deposition rate of 3‐mol%‐Y 2 O 3 ‐doped tetragonal‐ZrO 2 powder from ethanol suspensions are shown experimentally. Simultaneous acoustic and electroacoustic measurements make it possible to determine independently particle size and zeta‐potential in concentrated ethanol suspension. It is suggested that ionic (Na + ) surface contamination, which is reduced by laundering cycles, is the cause of the low zeta‐potential and deposition rate of the as‐received powder.
Variability in morphology, hygroscopicity, and optical properties of soot aerosols during atmospheric processing (2008)

The atmospheric effects of soot aerosols include interference with radiative transfer, visibility impairment, and alteration of cloud formation and are highly sensitive to the manner by which soot is internally mixed with other aerosol constituents. We present experimental studies to show that soot particles acquire a large mass fraction of sulfuric acid during atmospheric aging, considerably altering their properties. Soot particles exposed to subsaturated sulfuric acid vapor exhibit a marked change in morphology, characterized by a decreased mobility-based diameter but an increased fractal dimension and effective density. These particles experience large hygroscopic size and mass growth at subsaturated conditions (<90% relative humidity) and act efficiently as cloud-condensation nuclei. Coating with sulfuric acid and subsequent hygroscopic growth enhance the optical properties of soot aerosols, increasing scattering by approximately 10-fold and absorption by nearly 2-fold at 80% relative humidity relative to fresh particles. In addition, condensation of sulfuric acid is shown to occur at a similar rate on ambient aerosols of various types of a given mobility size, regardless of their chemical compositions and microphysical structures. Representing an important mechanism of atmospheric aging, internal mixing of soot with sulfuric acid has profound implications on visibility, human health, and direct and indirect climate forcing.
ChemInform Abstract: A NOVEL 1,4‐CYCLOADDITION REACTION OF A STABLE 2‐THIANAPHTHALENE DERIVATIVE. FORMATION AND X‐RAY CRYSTAL STRUCTURE OF 3‐BENZOYL‐1A,2‐DIMETHOXYCARBONYL‐1‐METHYLTHIO‐1A,7B‐DIHYDROCYCLOPROPA(A)NAPHTHALENE (1981)

Abstract Das stabile Thianaphthalinderivat (I) ergibt mit (II) über eine Thiochroman‐Ylid‐zwischenstufe das Cycloaddukt (II′I), dessen Persäure‐Oxidation zum Sulfon (IV) führt.
Influence of entanglement on the dielectric normal mode process of cis-polyisoprene (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleInfluence of entanglement on the dielectric normal mode process of cis-polyisopreneKeiichiro Adachi and Tadao KotakaCite this: Macromolecules 1984, 17, 1, 120–122Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/ma00131a023https://doi.org/10.1021/ma00131a023research-articleACS PublicationsRequest reuse permissionsArticle Views273Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Subnuclear partitioning and functional regulation of the Pit-1 transcription factor (1999)

Subnuclear compartmentation is postulated to play an important role in many aspects of nuclear metabolism. To directly test an application of this model to transcription factor function, we examined the subnuclear partitioning behavior of Pit-1, a tissue-specific, POU-class transactivator. Biochemical and in situ assays indicate the nuclear pool of Pit-1 is normally divided between two compartments: the majority being differentially soluble in detergent, and a significant insoluble fraction (approximately 20%) bound to the nuclear matrix. Examination of Pit-1 deletion mutants and chimeric fusions reveal the highly conserved 66 amino acid POU-specific domain contains a necessary and sufficient nuclear matrix targeting signal. The nuclear partitioning behavior of several natural or engineered point mutations of Pit-1 was also examined. Surprisingly, the inactive point mutants were completely matrix-bound, irrespective of their ability to bind Pit-1 specific DNA. These results suggest that dynamic partitioning of Pit-1 is a component of its normal transactivator function that takes place upon the insoluble nuclear substructure where transcription occurs.
Regulation of the Human Oxytocin Receptor by Nuclear Factor-κB and CCAAT/Enhancer-Binding Protein-β (2006)

IL-1beta has a biphasic effect on OTR expression in myometrial cells, and C/EBP and NF-kappaB play synergistic roles in OTR promoter activation.
The Singer's Guide to Pronunciation; With an Appendix, Consisting of a Pronouncing Dictionary of Musical Terms and the Rules of Italian Pronunciation (1873)

25I 25I 25I 25I 25I 25I 25I 25I 25Iboth sprightly and melodious, althouCh ure are inclined to think the Galop by far the better of the two.The Polka is somewhat laboured. Tears, icGle tea7ts
Scale Construction of the Swedish CPRS Version (1985)

A sample of 161 schizophrenic and depressive patients were interviewed in a Stockholm hospital to find out whether the Comprehensive Psychopathological Rating Scale construction carried out by Maurer et al. [Int. Pharmacopsychiat. 17: 338-353, 1982] and valid for German-speaking areas could be reproduced with a Swedish-speaking sample. Only the superimposed 2-factor solution resembled, in its factor-structure, that of Maurer et al. (depressive and schizophrenic syndrome). The fact that a 'depressive' syndrome was found instead of a 'manic-depressive' syndrome, is to be attributed to the different sample compositions.
The relation between urinary incontinence and steroid hormone levels in perimenopausal women. A report from the Women's Health in the Lund Area (WHILA) study (2009)

UI in middle-aged women seems related to higher serum estradiol levels. This corroborates with studies showing a higher incidence and/or prevalence of UI in women on hormone therapy. No association between UI and serum levels of cortisol, testosterone, or androstendione was found.
An Integrated Approach to Finite Element Model Validation: Software Tools and Case Study in Automotive Industry (1993)

<div class="section abstract"><div class="htmlview paragraph">The theoretical basis and practical implementation of software for correlating and updating finite element models with experimental modal analysis is described, with emphasis on the key features and problem areas of these techniques. The validation of a finite element model using a sensitivity-based method and weighted updating of physical parameters of the model in an integrated computer program is described. This enables the analyst to improve the quality and reliability of the FE model and the modeling methodology. Some typical applications are presented, with a detailed case study in which, at first, there is very poor agreement between the analytical and experimental data. It is concluded that these numerical techniques for model updating allow a user to create improved models which represent reality much better than the original ones.</div></div>
Farewell and Welcome to the New Editor-In-Chief (2015)

Discusses the naming of a new Editor-in-Chief for this publications as well as a farewell message to the outgoing EIC.