gebhart/patrepeval huggingface dataset:
A New Approach to the Thermal Analysis of Electrical Distribution Systems (2011)

<div class="section abstract"><div class="htmlview paragraph">The optimum design of an electrical distribution system (EDS) is based on the profound understanding and measurement of its thermal behavior, because this determines wire diameter and insulation material, has a major impact on the fusing strategy, and enables minimizing technical risk. Current methods of calculation require an extensive database, whereas the temperature measurements at selected points with normal sensors allow neither the precise rating of the actual insulation temperature within a wire bundle, nor the determination of the thermal impact of load currents.</div><div class="htmlview paragraph">The presented approach is based on both a new measurement method and on a related evaluation algorithm. A common automotive wire is applied as a sensing device using its resistance temperature coefficient as the measurement principle. Sectioning of the wire provides the required spatial resolution, and variation of the measurement current determines both the thermal dynamic behavior and the impact of electrical losses. A model-based algorithm allows the non-destructive evaluation of overcurrent scenarios and the thermal rating of the other wires within the bundle. The paper presents initial experimental data followed by a discussion of the next steps and future potentials.</div></div>
Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial (2021)

Although intranasal oxytocin is expected to be a novel therapy for the core symptoms of autism spectrum disorder, which has currently no approved medication, the efficacy of repeated administrations was inconsistent, suggesting that the optimal dose for a single administration of oxytocin is not optimal for repeated administration. The current double-blind, placebo-controlled, multicentre, crossover trial (ClinicalTrials.gov Identifier: NCT03466671) was aimed to test the effect of TTA-121, a new formulation of intranasal oxytocin spray with an enhanced bioavailability (3.6 times higher than Syntocinon® spray, as assessed by area under the concentration-time curve in rabbit brains), which enabled us to test a wide range of multiple doses, on autism spectrum disorder core symptoms and to determine the dose-response relationship. Four-week administrations of TTA-121, at low dose once per day (3 U/day), low dose twice per day (6 U/day), high dose once per day (10 U/day), or high dose twice per day (20 U/day), and 4-week placebo were administered in a crossover manner. The primary outcome was the mean difference in the reciprocity score (range: 0-14, higher values represent worse outcomes) on the Autism Diagnostic Observation Schedule between the baseline and end point of each administration period. This trial with two administration periods and eight groups was conducted at seven university hospitals in Japan, enrolling adult males with high-functioning autism spectrum disorder. Enrolment began from June 2018 and ended December 2019. Follow-up ended March 2020. Of 109 males with high-functioning autism spectrum disorder who were randomized, 103 completed the trial. The smallest P-value, judged as the dose-response relationship, was the contrast with the peak at TTA-121 6 U/day, with inverted U-shape for both the full analysis set (P = 0.182) and per protocol set (P = 0.073). The Autism Diagnostic Observation Schedule reciprocity score, the primary outcome, was reduced in the TTA-121 6 U/day administration period compared with the placebo (full analysis set: P = 0.118, mean difference = -0.5; 95% CI: -1.1 to 0.1; per protocol set: P = 0.012, mean difference = -0.8; 95% CI: -1.3 to -0.2). The per protocol set was the analysis target population, consisting of all full analysis set participants except those who deviated from the protocol. Most dropouts from the full analysis set to the per protocol set occurred because of poor adherence to the test drug (9 of 12 in the first period and 8 of 15 in the second period). None of the secondary clinical and behavioural outcomes were significantly improved with the TTA-121 compared with the placebo in the full analysis set. A novel intranasal spray of oxytocin with enhanced bioavailability enabled us to test a wide range of multiple doses, revealing an inverted U-shape dose-response curve, with the peak at a dose that was lower than expected from previous studies. The efficacy of TTA-121 shown in the current exploratory study should be verified in a future large-scale, parallel-group trial.
ACTION OF INTESTINAL EXTRACTS ON “BRANCHED” OLIGOSACCHARIDES<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTACTION OF INTESTINAL EXTRACTS ON “BRANCHED” OLIGOSACCHARIDES1Joseph Larner and C. M. McNickleCite this: J. Am. Chem. Soc. 1954, 76, 18, 4747–4748Publication Date (Print):September 1, 1954Publication History Published online1 May 2002Published inissue 1 September 1954https://doi.org/10.1021/ja01647a085RIGHTS & PERMISSIONSArticle Views36Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (282 KB) Get e-Alertsclose Get e-Alerts
Localization of inclusion bodies in Escherichia coli overproducing beta-lactamase or alkaline phosphatase (1986)

High-level synthesis of the periplasmic protein beta-lactamase in Escherichia coli caused the formation of insoluble protein precipitates called inclusion bodies. beta-Lactamase inclusion bodies differed from those reported previously in that they appeared to be localized in the periplasmic space, not in the cytoplasm. The inclusion bodies contained mature beta-lactamase and were solubilized more easily than has been reported for cytoplasmic inclusion bodies. In contrast, overproduction of the periplasmic protein alkaline phosphatase caused the formation of cytoplasmic inclusion bodies containing alkaline phosphatase precursor.
HIV Subtype D Is Associated with Dementia, Compared with Subtype A, in Immunosuppressed Individuals at Risk of Cognitive Impairment in Kampala, Uganda (2020)

In the United States, clade B is the predominant human immunodeficiency virus (HIV) subtype, whereas in sub-Saharan Africa, clades A, C, and D are the predominant subtypes. HIV subtype may have an impact on HIV disease progression. The effect of HIV subtype on the risk of dementia has, to our knowledge, not been examined. The objective of this study was to examine the relationship between HIV subtype and the severity of HIV-associated cognitive impairment among individuals initiating antiretroviral therapy in Uganda.
<title>Neural Analog Processing</title> (1983)

This paper presents a bionic approach to pattern classification entitled Neural Analog Processing (NAP). NAP systems are based upon information processing principles discovered by neural modelers, but are not themselves neural models. To set the stage for a discussion of how NAP systems work, the theory of a particular type of local-in-time template-matching classifier -- the Generalized Nearest Neighbor (GNN) classifier -- for general time-varying patterns (imagery, spectra, tactile signals, etc.) is reviewed. The definition and function of the fundamental NAP structure -- the slab -- is then presented and it is shown that a GNN classifier can, in principle, be implemented using slabs. The embellishments necessary to allow NAP systems to be realized in hardware are then described. Finally, a summary of NAP system characteristics is presented.
Transplantation-Mediated Alloimmune Thrombocytopenia: Guidelines for Utilization of Thrombocytopenic Donors (2008)

Transplantation-mediated alloimmune thrombocytopenia (TMAT) is donor-derived thrombocytopenia following solid-organ transplantation. To date, no clear consensus on the appropriateness of organ utilization from cadaver donors with a history of idiopathic thrombocytopenia purpura (ITP) has emerged. Herein is reported a devastating case of TMAT following liver transplantation utilizing an allograft from a donor with ITP that resulted in allograft failure. The literature is reviewed in this context to propose preliminary guidelines regarding utilization of allografts from cadaver donors with a history of ITP.
On Determining Sensitivity to Pain in Borderline Personality Disorder—Reply (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Mechanisms of finite temperature magnetism in the three-dimensional Hubbard model (2015)

We examine the nature of the transition to the antiferromagnetically ordered state in the half-filled three-dimensional Hubbard model using the dual-fermion multiscale approach. Consistent with analytics, in the weak-coupling regime we find that spin-flip excitations across the Fermi surface are important, and that the strong coupling regime is described by Heisenberg physics. In the intermediate interaction, strong correlation regime we find aspects of both local and non-local correlations. We analyze the critical exponents of the transition in the strong coupling regime and find them to be consistent with Heisenberg physics down to an interaction of $U/t=10$.
Mono-ubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes (2017)

Abstract Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required for epithelial polarity. A fraction of Stx3 is localized to late endosomes / lysosomes though how it traffics there and its function in these organelles is unknown. Here we report that Stx3 undergoes mono - ubiquitination in a conserved polybasic domain. Stx3 present at the basolateral – but not the apical - plasma membrane is rapidly endocytosed, targeted to endosomes, internalized into intraluminal vesicles (ILVs) and excreted in exosomes. A non - ubiquitinatable mutant of Stx3 (Stx3 - 5R) fails to enter this pathway and leads to the inability of the apical exosomal cargo protein GPRC5B to enter the ILV / exosomal pathway. This suggests that ubiquitination of Stx3 leads to removal from the basolateral membrane to achieve apical polarity, that Stx3 plays a role in the recruitment of cargo to exosomes, and that the Stx3 - 5R mutant acts as a dominant - negative inhibitor. Human cytomegalovirus (HCMV) acquires its membrane in an intracellular compartment and we show that Stx3 - 5R strongly reduces the number of excreted infectious viral particles. Altogether these results suggest that Stx3 functions in the transport of specific proteins to apical exosomes and that HCMV exploit this pathway for virion excretion.
Maintaining uniformity of IR focal plane arrays by updating offset correction coefficients (2003)

An infrared focal plane array (FPA) non-uniformity correction (NUC) method is considered, in which two-point calibration (TPC) table is calculated and stored at the factory, and the offset correction is carried out periodically during the mission. An InSb FPA is examined, and the stability of the NUC is measured over various periods (up to 9 months) and also under variations of the FPA temperature and integration time. We find that the NUC quality and its stability comply with the system requirements. We find, also, that the stability of the NUC is better maintained by using a single TPC table for the entire detector dynamic range, as compared to the multiple (piece-wise-linear) TPC. A simple phenomenological model of the detector non-linearity is proposed, which fits the experimental data better than the quadratic non-linearity model.
Photo-induced release of active plasmid from crosslinked nanoparticles: o-nitrobenzyl/methacrylate functionalized polyethyleneimine (2010)

To facilitate DNA packaging and photolytic release, o-nitrobenzyl and methacrylate functionalized PEI (P10A) was synthesized for condensing DNA into nanoparticles as small as 160 nm after radical polymerization with initiator. The gene expression following delivery of uncross-linked P10A/DNA was unchanged by photoirradiation of cells. However, exposure to photo-irradiation caused a 3-fold increase in gene expression in cells transfected with cross-linked P10A/DNA. These polyplexes were designed to mimic viral particles that condense and protect DNA while allowing subsequent triggered release of DNA.
Locomotor Adaptation to an Asymmetric Force on the Human Pelvis Directed Along the Right Leg (2015)

In this work, we study locomotor adaptation in healthy adults when an asymmetric force vector is applied to the pelvis directed along the right leg. A cable-driven Active Tethered Pelvic Assist Device (A-TPAD) is used to apply an external force on the pelvis, specific to a subject's gait pattern. The force vector is intended to provide external weight bearing during walking and modify the durations of limb supports. The motivation is to use this paradigm to improve weight bearing and stance phase symmetry in individuals with hemiparesis. An experiment with nine healthy subjects was conducted. The results show significant changes in the gait kinematics and kinetics while the healthy subjects developed temporal and spatial asymmetry in gait pattern in response to the applied force vector. This was followed by aftereffects once the applied force vector was removed. The adaptation to the applied force resulted in asymmetry in stance phase timing and lower limb muscle activity. We believe this paradigm, when extended to individuals with hemiparesis, can show improvements in weight bearing capability with positive effects on gait symmetry and walking speed.
Antioxidant activity of 5-FU and new fluorinated uracil derivates (2017)

The intake of antioxidants has increased in the last years in order to treat some pathologies associated with oxidative stress such as cancer, diabetes mellitus, atherosclerosis, myocardial infarction, acute pancreatitis, Parkinson's and Alzheimer's disease among others. In colorectal cancer, a widely antineoplastic drug used is the fluorinated uracil molecule 5-Fluorouracile (5-FU). The aim of this study is to assess the antioxidant capacity observed by the inhibition of lipid peroxidation by 5-FU and other fluorinated uracil derivates: 6-[Difluoro(phenyl)methyl]-3-(2,4,6-trifluorophenyl)pyrimidine-2,4(1H,3H)-dione (S-81), 3-[2-Chloroethyl]-6-[difluoro(phenyl)methyl]pyrimidine-2,4(1H,3H)-dione (S-86), 6-[Difluoro(phenyl)methyl]-3-(4-trifluoromethoxyphenyl)pyrimidine-2,4(1H,3H)-dione (S-123). The results showed a significant decrease in MDA production of 58.12% in S-86, 44.61% in S-123, 24.11% in 5-FU and 10.83% in S-81 in the sample with highest concentration (10µM). 5-FU also showed a Total Antioxidant Capacity of 0.68 Trolox Equivalent Antioxidant Capacity.
Zugriffsschutz für OSI-Management (1995)

Während die Sicherheitsproblemaktik von Network Management Anwendungen seit langem bekannt ist und ihre Lösungen in den OSI-Spezifikationen der X.700-Serie beschrieben sind, gibt es bisher kaum Erfahrungen mit ihrer Implementie rung. Dieses Papier gibt eine kritische Sicht auf den OSI-Standard von Authentifizierung und Zugriffsschutz für Managementanwendungen und beschreibt dann unsere Erfahrung mit seiner Implementierung. Unsere Implementierung wurde mit Hilfe von OSIMaDE, SecuDE und IsoDE im BMSec-Projekt realisiert. Die verwendeten Abkürzungen und Akronyme sind am Ende dieses Artikels erläutert.
Effect of Cryptorchidism on Human Testicular Transcriptome. (2010)

Cryptorchidism is the most common congenital disorder in boys. One major consequence of this anomaly is male infertility due to undescended testis to which an increased risk of testicular cancer is associated. The genetic cause of cryptorchidism remains to be elucidated. The objective of this study was to compare the transcriptome of human cryptorchid testis with normal tissues. Seminoma tissues were used as a positive control of genes known to be expressed in testicular cancer. Normal tissues were obtained with collaboration of our local organ transplantation program; the five donors were from 23 to 53 years of age. Cryptorchid testes were obtained by surgical orchidectomy performed on 4 patients from 29 to 43 years of age presenting with inguinal testis. Donors of seminoma tissues were from 22 to 34 years of age and were obtained through the pathological tissues bank of our institution. Tissues samples were kept on ice and snap freeze immediately upon arrival in the research lab. Total RNA was extracted from the tissues and used to probe Affymetrix GeneChip Human Gene 1.0 ST arrays which include 28,869 genes with 764,885 distinct probes. In normal and cryptorchid tissues 2278 and 589 genes were up-regulated, respectively. As expected, transcripts known to be associated with spermatogenesis characterized the normal tissues whereas, in cryptorchid testes, transcripts of Leydig and Sertoli cells were found in higher amount. For example, PRM1 and ADAM2 transcripts associated to germ cells were in higher quantity in normal than cryptorchid testes, but CYP17A1, LHR and HSD17B3 transcripts of Leydig cells as well as GATA4, INHA and INHBA transcripts of Sertoli cells were higher in cryptorchid than normal testes. Some transcripts known to be associated with testicular cancer, such as CALR3 and PIWIL1, were up-regulated in normal tissues whereas KITLG and CCND2 were more expressed in cryptorchid testes. In seminoma tissues, PIWIL1 transcript was more expressed in cryptorchid but less in normal testicular cancer; the CALR3 and KITLG were less expressed in seminoma than in other tissues whereas the CCND2 was much more expressed in cancer tissues. Markers for testicular descent were more expressed in cryptorchids than in normal and seminomas as expected. These transcript expression patterns from the microarray results were confirmed by quantitative real-time PCR. Differences in transcriptome due to cryptorchidism will give us a clue to find the genetic cause of this disease. This work was supported by Canadian Institute of Health Research grant to Robert Sullivan.
Mef2A, a homologue of animal Mef2 transcription factors, regulates cell differentiation in Dictyostelium discoideum (2013)

Our data shows that mef2A plays a role in cell differentiation in D. discoideum and modulates the expression of prespore and prestalk genes.
Image Decomposition With Multilabel Context: Algorithms and Applications (2011)

Most research on image decomposition, e.g., image segmentation and image parsing, has predominantly focused on the low-level visual clues within a single image and neglected the contextual information across images. In this paper, we present a new perspective to image decomposition piloted by the multilabel context associated with each individual image. Observing that the contextual information (i.e., local label representations of the same label are similar while those from different labels are dissimilar) exists across images, we propose to perform image decomposition in a collective way and obtain an optimal representation for each label from a set of multilabeled images. We formulate the problem as an optimization problem which maximizes inter-label difference while minimizing the intra-label difference of the target label representations and propose two ways to solve this problem. Such a contextual image decomposition has a wide variety of applications, among which two exemplary ones-multilabel image annotation and label ranking, are presented and evaluated with different classification techniques. Extensive experiments on two benchmark datasets demonstrate promising results.
ChemInform Abstract: A Discriminating Protecting Group Strategy for Alcohols and Amines. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.