gebhart/patrepeval huggingface dataset:
The Use of LSD in Psychotherapy (1970)

(1970). The Use of LSD in Psychotherapy. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 52-62.
Self-organizing feature maps for dynamic control of radio resources in CDMA microcellular networks (1998)

The application of artificial neural networks to the channel assignment problem for cellular code-division multiple access (CDMA) cellular networks has previously been investigated. CDMA takes advantage of voice activity and spatial isolation because its capacity is only interference limited, unlike time-division multiple access (TDMA) and frequency-division multiple access (FDMA) where capacities are bandwidth-limited. Any reduction in interference in CDMA translates linearly into increased capacity. To satisfy the high demands for new services and improved connectivity for mobile communications, microcellular and picocellular systems are being introduced. For these systems, there is a need to develop robust and efficient management procedures for the allocation of power and spectrum to maximize radio capacity. Topology-conserving mappings play an important role in the biological processing of sensory inputs. The same principles underlying Kohonen's self-organizing feature maps (SOFMs) are applied to the adaptive control of radio resources to minimize interference, hence, maximize capacity in direct-sequence (DS) CDMA networks. The approach based on SOFMs is applied to some published examples of both theoretical and empirical models of DS/CDMA microcellular networks in metropolitan areas. The results of the approach for these examples are informally compared to the performance of algorithms, based on Hopfield- Tank neural networks and on genetic algorithms, for the channel assignment problem.
Heterologous production of small molecules in the optimized<i>Streptomyces</i>hosts (2019)

Time span of literature covered: 2010-2018The genome mining of streptomycetes has revealed their great biosynthetic potential to produce novel natural products. One of the most promising exploitation routes of this biosynthetic potential is the refactoring and heterologous expression of corresponding biosynthetic gene clusters in a panel of specifically selected and optimized chassis strains. This article will review selected recent reports on heterologous production of natural products in streptomycetes. In the first part, the importance of heterologous production for drug discovery will be discussed. In the second part, the review will discuss recently developed genetic control elements (such as promoters, ribosome binding sites, terminators) and their application to achieve successful heterologous expression of biosynthetic gene clusters. Finally, the most widely used Streptomyces hosts for heterologous expression of biosynthetic gene clusters will be compared in detail. The article will be of interest to natural product chemists, molecular biologists, pharmacists and all individuals working in the natural products drug discovery field.
DEVELOPMENTS OF SWAHILI RESOURCES FOR AN AUTOMATIC SPEECH RECOGNITION SYSTEM (2014)

This article describes our efforts to provide ASR resources for Swahili, a Bantu language spoken in a wide area of East Africa. We start with an introduction on the language situation, both at linguistic and digital level. Then, we report the selected strategies to develop a text corpus, a pronunciation dictionary and a speech corpus for this under-resourced language. We explore methodologies as crowdsourcing or collaborative transcription process. Besides, we take advantage of some linguistic characteristics of the language such as rich morphology or shared vocabulary with English to improve performance of our baseline Swahili ASR system in a broadcast speech transcription task. Index Terms — Swahili, under-resourced languages, automatic speech recognition, speech resources
Three types of 2-D lateral magnetoresistive sensors with p+-implant confinement (2000)

The paper presents three types of 2-D magnetic sensors fabricated by an industrial 0.8 µm CMOS process. They are designed to measure the horizontal magnetic component Bx and the vertical magnetic component By, simultaneously. The devices with p+-implant confinement have been investigated experimentally. According to experimental results, the magnitudes of the cross-coupling noises are proportional to the device size. Both the enlarged device size and the narrowed device conductive thickness with p+-implant confinement have higher sensitivity. The measured absolute voltage sensitivity SA, the absolute current sensitivity SI, and the supply-current-related sensitivity SRI are 0.741 V/T, 493.7 µA/T and 439.4 V/AT, respectively.
Relative conversion of arachidonic acid through lipoxygenase and cyclooxygenase pathways by homogenates of diseased periodontal tissues (1983)

The present study shows that 14C-arachidonic acid metabolism in gingiva of patients with periodontal disease is mainly via the lipoxygenase pathway. In two pools of gingival tissue homogenates, the lipoxygenase products contained 22.65% and 23.38%, while the prostaglandins (PGs), products of the cyclooxygenase pathway, contained only 4.85% and 3.98% of the total radioactivity incubated. 12-hydroxy-eicosatetraenoic acid (12-HETE), a lipoxygenase product, was detected as a major metabolite of arachidonic acid in gingiva.
Broad-Band Equivalent-Circuit Determination of Gunn Diodes (1970)

A method has been developed for the direct broad-band measurement of the impedance of a Gunn diode operating at a bias voltage exceeding threshold. This method is based upon determination of an equivalent-circuit model for the diode mount and package, which is found to be valid over the 1- to 20-GHz range. Using this circuit, the low-field diode equivalent circuit is found and takes the form of a parallel RC circuit as expected from the theory. An unusual result is that the low-field capacitance is found to be strongly dependent on the bias voltage; this dependence is presumed due to the free-carrier contribution to the effective dielectric constant. Some direct broad-band measurements are reported for an active Gunn diode biased beyond threshold. These measurements provide additional insight into the conditions under which significant parametric action may occur in a Gunn diode.
[The study on immune responses in BALB/c mice by immunization with the transgenic Alfalfa(Medicago sativa) containing Eg95-EgA31 fusion gene of Echinococcus granulosus]. (2010)

Apoptosis of splenocytes may be inhibited in mice by immunization with the transgenic alfalfa, splenocytes' proliferation and Th1 response can be induced in the mice against the challenge of Eg protoscoleces. CD4(+); T cell and the specific antibody(IgG, IgG2b and IgE) may play important roles in the protection induced by the transgenic alfalfa vaccine.
Photogrammetry: An Available Surface Characterization Tool for Solar Concentrators, Part I: Measurements of Surfaces (1996)

Close range photogrammetry is a sensing technique that allows the three-dimensional coordinates of selected points on a surface of almost any dimension and orientation to be assessed. Surface characterisations of paraboloidal reflecting surfaces at the ANU using photogrammetry have indicated that three-dimensional coordinate precisions approaching 1:20,000 are readily achievable using this technique. This allows surface quality assessments to be made of large solar collecting devices with a precision that is difficult to achieve with other methods.
On some dynamical diagrams of chemical reaction engineering (1999)

A brief historical survey of some of the influential types of diagrams that have been used in chemical reaction engineering is given. These include the phase plane, the simple autocatalytic diagram, and the stroboscopic phase plane. (c) 1999 American Institute of Physics.
In Vitro and In Vivo Effects of Phenolic Antioxidants against Cisplatin-Induced Nephrotoxicity (1999)

We have investigated the effect of phenolic antioxidants on cisplatin-induced cytotoxicity in vero (African Green Monkey Kidney) cells and in rat renal cortical slices in vitro, and on cisplatin-induced nephrotoxicity in rats in vivo. Incubation of cisplatin with vero cells resulted in time- and concentration-dependent cytotoxicity, as characterized by decreased tryphan blue exclusion (TBE) and increased release of lactate dehydrogenase (LDH) into the medium. Cisplatin also caused reduction of glutathione (GSH) in a concentration-dependent manner. In the rat renal cortical slices model, incubation of cisplatin for 120 min caused an increase in malondialdehyde (MDA), a decrease in GSH and inhibited p-aminohippurate (PAH) uptake in a concentration-dependent manner. Among phenolic antioxidants, isoeugenol (IG) was found to be more active against cisplatin-induced cytotoxicity in vero cells as well as in rat renal cortical slices than eugenol (EG) and dehydrozingerone (DZ). However none of the test compounds were able to arrest the reduction of the GSH content induced by cisplatin in either the vero cells or the renal cortical slice model. Administration of cisplatin (3 mg/kg) i.p. to rats resulted in significant reduction of body weight, and elevation of blood urea nitrogen (BUN) and serum creatinine. Treatment with IG 10 mg/kg i.p. 1 h before cisplatin resulted in partial but significant protection against the cisplatin-induced reduction of body weight, and elevation of BUN and serum creatinine, the protection being 34, 46, and 62%, respectively. EG and DZ (10 mg/kg, i.p.) were found to be inactive in vivo. Because IG is a potent free radical scavenger and protects against cisplatin-induced toxicitiy, the present results have many clinical implications in chemotherapy and thus warrants further investigation.
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds (2009)

Histone deacetylase (HDAC) inhibitors reactivate epigenetically-silenced genes in cancer cells, triggering cell cycle arrest and apoptosis. Recent evidence suggests that dietary constituents can act as HDAC inhibitors, such as the isothiocyanates found in cruciferous vegetables and the allyl compounds present in garlic. Broccoli sprouts are a rich source of sulforaphane (SFN), an isothiocyanate that is metabolized via the mercapturic acid pathway and inhibits HDAC activity in human colon, prostate, and breast cancer cells. In mouse preclinical models, SFN inhibited HDAC activity and induced histone hyperacetylation coincident with tumor suppression. Inhibition of HDAC activity also was observed in circulating peripheral blood mononuclear cells obtained from people who consumed a single serving of broccoli sprouts. Garlic organosulfur compounds can be metabolized to allyl mercaptan (AM), a competitive HDAC inhibitor that induced rapid and sustained histone hyperacetylation in human colon cancer cells. Inhibition of HDAC activity by AM was associated with increased histone acetylation and Sp3 transcription factor binding to the promoter region of the P21WAF1 gene, resulting in elevated p21 protein expression and cell cycle arrest. Collectively, the results from these studies, and others reviewed herein, provide new insights into the relationships between reversible histone modifications, diet, and cancer chemoprevention.
Platinum‐Group Metals (2012)

Abstract The platinum‐group metals (PMGs), ie, platinum, palladium, rhodium, ruthenium, osmium, and iridium, all have high melting points and exceptional corrosion resistance. Platinum, rhodium, and iridium are particularly stable to oxidation at high temperatures. These metals, especially platinum and palladium, show exceptional catalytic properties. In nature, platinum‐group metals frequently occur with nickel, copper, and iron sulfides. The principal producing region is South Africa. In the refining of these metals, solvent extraction technology is increasingly replacing conventional hydrometallurgical processes. Benefits include increased recovery, improved efficiency and significantly shortened process times. Resources and processes are discussed. The primary end use for palladium, platinum, and rhodium is for catalytic converters in the automotive industry. Other uses for PMGs are in the jewelry sector, electronics, petroleum refining, glassmaking, medical sector, automotive sensors, coatings of aircraft turbine blades and spark plugs. Platinum is purchased as small bars and coins.
Simple coding scheme to reduce peakfactor in QPSK multicarrier modulation (1995)

The authors present a simple half-rate coding scheme to limit the peak factor of QPSK multicarrier waveforms to less than one quarter that of the uncoded carrier, using Rudin-Shapiro polynomials.
Assessment of Myocardial Viability in Patients with Heart Failure (2007)

The prognosis for patients with chronic ischemic left ventricular dysfunction is poor, despite advances in different therapies. Noninvasive assessment of myocardial viability may guide patient management. Multiple imaging techniques have been developed to assess viable and nonviable myocardium by evaluating perfusion, cell membrane integrity, mitochondria, glucose metabolism, scar tissue, and contractile reserve. PET, (201)Tl and (99m)Tc scintigraphy, and dobutamine stress echocardiography have been extensively evaluated for assessment of viability and prediction of clinical outcome after coronary revascularization. In general, nuclear imaging techniques have a high sensitivity for the detection of viability, whereas techniques evaluating contractile reserve have a somewhat lower sensitivity and a higher specificity. MRI has a high diagnostic accuracy for assessment of the transmural extent of myocardial scar tissue. Patients with a substantial amount of dysfunctional but viable myocardium are likely to benefit from coronary revascularization and may show improvements in regional and global contractile function, symptoms, exercise capacity, and long-term prognosis.
Increased Tumorigenesis Induced by<italic>N</italic>-Nitrosobis(2-oxopropyl)amine in Syrian Golden Hamsters Fed High-Fat Diets1.<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref> (1983)

The effects of dietary fat on carcinogenesis were presented, with the pancreas excluded, in randombred Syrian golden hamsters after administration of N-nitrosobis(2-oxopropyl)amine (BOP). Diets containing 4.5, 9, or 18 g corn oil/385 kilocalories [low-fat (LF), medium-fat (MF), or high-fat (HF) diet, respectively] were fed in two sequences. In the first sequence during which the effects of fat on the initiation phase of BOP carcinogenicity were examined, LF or HF diets were fed to hamsters 3-7 weeks of age and for 2 days after a single sc BOP treatment (10 mg/kg body wt) to 8-week-old hamsters. These hamsters were then given MF diet for the remainder of their lives. In the second sequence during which the role of fat on the promotional phase (development) of BOP-induced cancer was evaluated, MF diet was fed during the weeks preceding BOP treatment and LF or HF levels were given after BOP treatment. Separate groups were fed MF diet throughout both phases, and parallel animal groups received each diet sequence and were treated with saline at 8 weeks of age. Renal adenocarcinomas in males were observed only in those given HF diet either before or after BOP treatment (9% incidence). Similarly, pulmonary adenoma and intraphepatic biliary cystic adenoma (cholangioma) incidences were elevated above spontaneous rates in HF-fed groups. This study demonstrated that dietary fat enhanced BOP-induced tumorigenesis in the kidneys, lungs, and liver when fed, either during initiation (preceding carcinogen treatment) or at promotional stages (following carcinogen treatment).
Corticosteroid therapy in a Chinese patient with nephropathy associated with human immunodeficiency virus infection. (2004)

A 52-year-old man with 6 years' history of human immunodeficiency virus infection who was receiving highly active antiretroviral therapy presented with acute renal failure and nephrotic syndrome. Renal biopsy revealed features consistent with nephropathy associated with human immunodeficiency virus infection. Treatment consisted of intravenous methylprednisolone followed by oral prednisolone. The patient's renal function improved, although proteinuria persisted. Human immunodeficiency virus-associated nephropathy is very rare in Asian populations and is more common among blacks. To the best of our knowledge, this is the first documented case of nephropathy associated with human immunodeficiency virus infection occurring in Hong Kong.
先进的烧结-硬化材料在汽车齿轮、凸轮及链轮等中的应用 (2010)

最近的汽车产业应用,要求具有高表观硬度、高淬透性及高力学性能的粉末冶金零件材料。这些要求往往是相互矛盾的,因此需要开发烧结态具有高表观硬度、良好静态动态力学性能又不会增加后续热处理费用的新材料。传统上,烧结硬化材料具有适用的表观硬度,但力学性能与烧结体密度差。这里将用资料证明具有良好压缩性,高表观硬度及提高力学性能的一系列烧结硬化材料的力学性能。集中讨论这些材料在汽车发动机与变速器中的应用,诸如齿轮、凸轮及链轮等,这些零件目前都是由压制-烧结及热处理工艺或由铸件或锻造材料用常规切削加工生产的。也将讨论用高温烧结来增强其工艺过程。
The biological actions of estrogens on skin (2002)

There is still extensive disparity in our understanding of how estrogens exert their actions, particularly in non-reproductive tissues such as the skin. Although it has been recognized for some time that estrogens have significant effects on many aspects of skin physiology and pathophysiology, studies on estrogen action in skin have been limited. However, estrogens clearly have an important function in many components of human skin including the epidermis, dermis, vasculature, hair follicle and the sebaceous, eccrine and apocrine glands, having significant roles in skin aging, pigmentation, hair growth, sebum production and skin cancer. The recent discovery of a second intracellular estrogen receptor (ERbeta) with different cell-specific roles to the classic estrogen receptor (ERalpha), and the identification of cell surface estrogen receptors, has provided further challenges to understanding the mechanism of estrogen action. It is now time to readdress many of the outstanding questions regarding the role of estrogens in skin and improve our understanding of the physiology and interaction of steroid hormones and their receptors in human skin. Not only will this lead to a better understanding of estrogen action, but may also provide a basis for further interventions in pathological processes that involve dysregulation of estrogen action.
Super-resolution and ultra-sensitivity of angular rotation measurement based on SU(1,1) interferometers using homodyne detection (2017)

We theoretically explore the angular rotation measurement sensitivity of SU(1,1) interferometers with a coherent beam and a vacuum beam input by using orbital angular momentum (OAM). Compared with the OAM in an SU(2) interferometer, the SU(1,1) interferometer employing homodyne detection can further surpass the angular rotation shot noise limit and improve the resolution and sensitivity of angular rotation measurement. Two models are considered, one is that OAM is carried by a probe beam and the other one is a pump beam with the OAM. The sensitivity can be improved by higher OAM and nonlinear process with a large gain. The resolution can be enhanced in the case that the pump beam has OAM. Moreover, we present a brief discussion on the variation of resolution and sensitivity in the presence of photon loss.
[Studies on method for the determination of kaerophyllin in Bupleurum smithii wolff Wolff var. parvifolium]. (2000)

The result was precise and stable. This method was sensitive and its repeatability was excellent. This method may serve determination of kaerophyllin in B. smithii var. parvifolium.
Water treatment by pulsed streamer discharges (2003)

The reliable and durable reactor for wastewater treatment by pulsed streamer discharges is designed and tested. Uniform streamer discharges were obtained in water at pulsed electric loading. The volume of these discharges exceeds 200 cm/sup 3/ and the energy delivered to the discharge reached 40-400 J depending on the applied voltage. High amplitude of the voltage pulse applied to the reactor requires improved electric insulation to prevent the flashovers along the reactor surface both in water and air. High energy deposition due to high discharge current adds the requirements to the mechanical durability of the system. Small-size reactor with the volume of approximately 1 liter withstands successfully both high electrical and mechanical stresses. The reactor is designed for research purposes, however it can be upgraded to use in high repetition-rate regime necessary for applications.
[Prognostic value of EGFR in colorectal cancer]. (2005)

The prognostic value of EGFR expression in colorectal cancer, usually evaluated by immunohistochemistry, is actually based on heterogeneous data, considering tumour stage or survival rates. Results are variable due to differences in evaluation criteria between studies. The development of standardized scoring systems and the evaluation of expression variability in tumour led to reconsider this question. It seems to be important to evaluate precisely EGFR reactivity in the deepest region of the tumour. The finding of a profile linked to worse prognosis could allow pointing out tumours where EGFR overexpression is associated to disease progression and therefore could help to define EGFR- inhibitors' indications in colorectal cancer.
Mechanical Obstruction of Bowel and Megacolon Caused by Fecal Impaction (2003)

Fecal impaction is a common condition, which may lead to dilatation of bowel loop and perforation of colon in rare cases. Surgical intervention may be needed while the obstruction can not be resolved by medical method. This 67 y/o man is a case with previous history of diabetes mellitus and ischemic cerebral infarction one year before his admission. He had been bed-ridden for half a year. He was admitted to this hospital due to respiratory failure Investigation revealed marked dilated colonic bowel loop. Under the impression of mechanical bowel obstruction, the patient received exploratory laparotomy. Fecal impaction as well as megacolon were the operative findings. The fecalith was squeezed downward gradually and then removed by digital evacuation through the anus. In a case of mechanical ileus, the possibility of fecal impaction should be kept in mind and evaluated by detailed examination.
Towards a Quantum Field Theory of Mind (2011)

I provide an historical account of my contributions to a theory of mind based on quantum physical consideration. In brief, mind appears to be a tachyonic (faster-than-light) and therefore atemporal field embedded throughout spacetime, which came into existence along with matter starting with the big bang and continuing to present day, in what makes up the sought-for Higgs field in particle physics colliders today. Consequently, I offer my speculations, based in quantum physics, on what we may call acausality and its intimate link to mind.
Evolution of Masers and Lasers (1966)

The art of masers and lasers is founded on Einstein's discovery of stimulated emission. This discovery led to a search for methods for establishing population inversion in a suitable material and hence to the construction of a radiation amplifier. In 1954 Townes and his students constructed the first microwave amplifier and oscillator based on the stimulated emission principle. Three-level solid masers followed quickly and speculations began on extending the art into the optical region. The first ruby laser was built in 1960 by Maiman. It was quickly followed by the four-level lasers of Sorokin and Stevenson and the He-Ne laser of Javan. Large scale search for additional laser materials and more effective laser techniques began in 1961. This fascinating and frantic effort is still in progress. Its highlights are briefly described.