gebhart/patrepeval huggingface dataset:
Inability of mitogen-activated lymphocytes obtained from patients with malignant primary intracranial tumors to express high affinity interleukin 2 receptors. (1990)

Patients with primary malignant brain tumors manifest a variety of abnormalities in cell-mediated and humoral immunity. Diminished T cell reactivity has been shown in these patients to be linked to deficiencies in interleukin 2 (IL-2) production that cannot be overcome by exogenous IL-2. In this study, specific binding of radiolabeled IL-2 to PHA-stimulated lymphocytes from brain tumor patients demonstrates that the number of high affinity interleukin 2 receptors (IL-2R) is greatly reduced. FACS analysis indicates that the relative density of the p55 protein (Tac protein) is lower on the mitogen-activated lymphocytes obtained from patients than on comparably treated lymphocytes from normal individuals. These data indicate that mitogen-stimulated lymphocytes obtained from patients have fewer functional high affinity IL-2R principally because of the failure to express sufficient levels of the p55 protein for association with the p75 protein. Northern analysis of total RNA isolated from mitogen-stimulated T cells from patients demonstrates normal levels of steady state mRNA, which codes for the p55 protein. Moreover, there is no defect in the postranslational processing of the primary translation product of this mRNA suggesting that normal levels of the p55 protein are produced in activated T cells from patients.
Oligo(dG)<sub>12–18</sub>aggregates result in non-homogeneity of oligo(dG)<sub>12–18</sub>-Poly(C) type primer-template (1977)

Studies on the absorption spectra of equimolar solutions of oligo(dG)12-18 and poly(C), poly(Cm) or poly(Ce) showed that only 13%, 3% and 3% of base pairs, repectively, form complexes. Upon centrifugation of oligo(dG)12-18 with a molar excess of poly(C) of poly(Cm) in an analytical and a preparative centrifuge, it was found that only a part of oligodeoxynucleotide sediments with the polynucleotide, i.e. more rapidly than oligo(dG)12-18, poly(C) or poly(Cm). Products of binding of oligo(dG)12-18 with poly(C), poly(Cm) or poly (Ce) direct the synthesis of poly (dG) by AMV reverse transcriptas in accordance with the reported characteristics of these primer-templates, as well as of the enzyme. These observations suggest that the solutions of oligo(dG)12-18 with (polyC) or its analogues, commonly used as primer-templates of RNA- and DNA-directed DNA polymerases, contain a polynucleotide, to which oligo(dG)12-18 aggregates are bound through a few nucleotides chains shorter than 12-18 residues. These chains of oligo(dG)12-18 containing the 3'-OH ends are capable of of initiating the reaction with DNA POLYMERASES.
Theoretical Analysis of using Identity Based PKI as the Authentication method in SQL (2013)

There are many authentications models used with SQL such as Forms-Based Authentication. This work will explore the possibility of using Identity Based PKI as the authentication model for SQL. The work looking at both sides SQL authentication and PKI from history of view then present Identity PKI based for SQL and the pros and cons of such model
PHAGE-TYPING AND ANTIBIOTIC-RESISTANCE OF STAPHYLOCOCCI ISOLATED IN A GENERAL HOSPITAL (1956)

Staphylococcus aureus isolated from various sources in a hospital, from March, 1953, to March, 1954, were phage-typed and tested for sensitivity to seven antibiotics. Of the dressings from 1400 clean operations, 15.7% were found to contain S. aureus and 8% of the postoperative wounds were clinically infected. Of 516 cultures, 95.4% were typable with the 32 phages used. Group III strains were predominant in the cultures from the patients and showed a higher degree of resistance to many of the antibiotics than did the strains of Groups I, II, and IV or the strains isolated from student nurses on starting their training, before exposure to the hospital environment. While a high proportion of strains in the hospital were resistant to the more commonly used antibiotics, penicillin, chlortetracycline, oxytetracycline, and streptomycin, very few strains were resistant to erythromycin, chloramphenicol, or neomycin. A new phage type '81', the causative agent of 50% of the boils and abscesses investigated, was discovered. This has been found to be a common strain in Canadian hospitals and its similarity to the Australian hospital strain '80' is pointed out.
Promotion of Remyelination by Immunoglobulins: Implications for the Treatment of Multiple Sclerosis (2005)

During the last decade immunomodulatory treatments have been shown to influence the natural course of multiple sclerosis (MS). However, demyelination in the central nervous system (CNS) still occurs and repair mechanisms are incomplete leading to neurological deficits. Currently, there is no therapy available to promote remyelination and thus enhance repair mechanisms. Both immunoglobulins directed against spinal cord homogenate and polyclonal immunoglobulins for intravenous use (IVIg) have been shown to support remyelination in the animal model of Theiler's virus encephalomyelitis (TMEV). Further studies have identified monoclonal antibodies that lead to remyelination in TMEV and a toxic demyelination model using lysolecithin. The shared characteristics of these monoclonal antibodies are an IgM isotype and the capacity to bind oligodendrocytes, independent of epitope specificity. Recently, two human monoclonal antibodies with remyelinating properties were described. Clinical trials with IVIg have so far failed to demonstrate clinical improvement in MS patients, but these studies only employed IgG preparations. However, recent experimental data both in vivo and in vitro underline the importance of IgM for remyelination. Thus future clinical trials are needed to evaluate the remyelination potential of IgM in human diseases. The design of monoclonal antibodies capable of promoting remyelination is a telling example for the design of new specific therapies derived from biological products like polyclonal immunoglobulins.
Calorie restriction extends the chronological lifespan of <i>Saccharomyces cerevisiae</i> independently of the Sirtuins (2007)

Calorie restriction (CR) extends the mean and maximum lifespan of a wide variety of organisms ranging from yeast to mammals, although the molecular mechanisms of action remain unclear. For the budding yeast Saccharomyces cerevisiae reducing glucose in the growth medium extends both the replicative and chronological lifespans (CLS). The conserved NAD(+)-dependent histone deacetylase, Sir2p, promotes replicative longevity in S. cerevisiae by suppressing recombination within the ribosomal DNA locus and has been proposed to mediate the effects of CR on aging. In this study, we investigated the functional relationships of the yeast Sirtuins (Sir2p, Hst1p, Hst2p, Hst3p and Hst4p) with CLS and CR. SIR2, HST2, and HST4 were not major regulators of CLS and were not required for the lifespan extension caused by shifting the glucose concentration from 2 to 0.5% (CR). Deleting HST1 or HST3 moderately shortened CLS, but did not prevent CR from extending lifespan. CR therefore works through a Sirtuin-independent mechanism in the chronological aging system. We also show that low temperature or high osmolarity additively extends CLS when combined with CR, suggesting that these stresses and CR act through separate pathways. The CR effect on CLS was not specific to glucose. Restricting other simple sugars such as galactose or fructose also extended lifespan. Importantly, growth on nonfermentable carbon sources that force yeast to exclusively utilize respiration extended lifespan at nonrestricted concentrations and provided no additional benefit when restricted, suggesting that elevated respiration capacity is an important determinant of chronological longevity.
Alterations Are Ahead at the OAM (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of public health improvements in health advances: The twentieth-century United States (2005)

Mortality rates in the United States fell more rapidly during the late nineteenth and early twentieth centuries than in any other period in American history. This decline coincided with an epidemiological transition and the disappearance of a mortality "penalty" associated with living in urban areas. There is little empirical evidence and much unresolved debate about what caused these improvements, however. In this article, we report the causal influence of clean water technologies--filtration and chlorination--on mortality in major cities during the early twentieth century. Plausibly exogenous variation in the timing and location of technology adoption was used to identify these effects, and the validity of this identifying assumption is examined in detail. We found that clean water was responsible for nearly half the total mortality reduction in major cities, three quarters of the infant mortality reduction, and nearly two thirds of the child mortality reduction. Rough calculations suggest that the social rate of return to these technologies was greater than 23 to 1, with a cost per person-year saved by clean water of about dollar 500 in 2003 dollars. Implications for developing countries are briefly considered.
Lid Flora in Blepharitis (1991)

The microbiologic evaluations of 332 consecutive patients with the primary diagnosis of chronic blepharitis were reviewed and compared to those of 160 control patients. The most commonly isolated organisms from lids with blepharitis were Staphylococcus epidermidis (95.8%), Propronibacterium acnes (92.8%), Corynebacterium sp. (76.8%), Acinetobacter sp. (11.4%), and Staphylococcus aureus (10.5%). Compared to controls, S. epidermidis (p less than 0.01), P. acnes (p less than 0.02), and Corynebacterium sp. (p less than 0.001) were present significantly more often. S. aureus and the isolation of more than one microbial species were not more common in blepharitis patients. Quantitatively, heavy growth, by total and individual species, was significantly more common in blepharitis patients (total, p less than 0.001; S. epidermidis, p less than 0.001, P. acnes, p less than 0.001). These data demonstrate that patients with blepharitis are more likely to have normal skin bacteria on their lids and in greater quantities than nonblepharitis patients.
Sierra Leone - Power and Water Project : environmental assessment (2004)

This environmental assessment for the Sierra Leone Power and Water Project proposes a sustainable solid waste management system in Freetown. Sierra Leone's ten-year rebel war severely impacted Freetown's economy and its infrastructure. Most of the waste management equipment such as the skip trucks, skips and others were vandalized or completely destroyed. The result of heavy population migration has been squalor, poor housing, inadequate sanitation, congestion, pollution, poor public services, and chronic unemployment, particularly among the youth, most of who are without any employable skills. The ubiquitous pile-up of garbage, can be seen everywhere. Also, most city drains are clogged with garbage. A number of manhole covers have been removed to dump garbage. Many existing skips (large containers) that also act as transfer station for the solid waste are broken. Often, the garbage is strewn around, where scavengers, mostly children and wandering dogs, birds, pigs, and other stray animals, forage amongst the rubbish, spreading it around. City's coastal area residents dump the wastes into the sea. In poor neighborhoods, collected waste is often set on fire. The situation is a major contributor to the city's significant rise of the incidence of vector-propagated diseases. The main issues apparent in the system are highly inefficient collection practices with quite a variable level of service, poor operating practices-including no environmental systems, highly inadequate and malfunctioning equipment, open burning of garbage, illegal dumping and littering, and a public seemingly indifferent to responsible waste management. Freetown's solid waste management system needs serious rehabilitation, first on an emergency basis, followed by development and implementation of long-term, sustainable measures. It also needs a change in behavior of individuals and the society. A successful solid waste management depends on an efficient operational system from the outset. This report addresses (i) storage, (ii) collection of waste, particularly industrial, hazardous, toxic, and medical wastes, (iii) street cleansing, and (iv) waste transport and disposal options such as open dumps, controlled dumps, sanitary landfills, anaerobic composting, incineration, and gasification and wet oxidation. As each of these precepts for sustainable SWM also requires careful planning and implementation by a financially sound, well-footed institute that has executive authorities and appropriate policy and legislative support, a new institute is proposed. The institutional arrangements involved in this entity's operation as well as proposed financing mechanisms, measures for stakeholder participation, the regulatory and legal framework, and monitoring and evaluation schemes are also discussed.
Oncolytic virus immunotherapies in ovarian cancer: moving beyond adenoviruses (2018)

Ovarian cancer is the 5th most common cancer in UK women with a high relapse rate. The overall survival for ovarian cancer has remained low for decades prompting a real need for new therapies. Recurrent ovarian cancer remains confined in the peritoneal cavity in >80% of the patients, providing an opportunity for locoregional administration of novel therapeutics, including gene and viral therapy approaches. Immunotherapy is an expanding field, and includes oncolytic viruses as well as monoclonal antibodies, immune checkpoint inhibitors, and therapeutic vaccines. Oncolytic viruses cause direct cancer cell cytolysis and immunogenic cell death and subsequent release of tumor antigens that will prime for a potent tumor-specific immunity. This effect may be further enhanced when the viruses are engineered to express, or coadministered with, immunostimulatory molecules. Currently, the most commonly used and well-characterized vectors utilized for virotherapy purposes are adenoviruses. They have been shown to work synergistically with traditional chemotherapy and radiotherapy and have met with success in clinical trials. However, pre-existing immunity and poor in vivo models limit our ability to fully investigate the potential of oncolytic adenovirus as effective immunotherapies which in turn fosters the need to develop alternative viral vectors. In this review we cover recent advances in adenovirus-based oncolytic therapies targeting ovarian cancer and recent advances in mapping immune responses to oncolytic virus therapies in ovarian cancer.
Potential involvement of leptin in carcinogenesis of hepatocellular carcinoma (2004)

High level expression and decreased or absent expression of leptin and its receptor in adjacent non-tumorous liver cells and HCC cells, inhibitory effect of leptin on the proliferation of normal Chang liver cells and no effect of leptin on proliferation of liver cancer cells, may provide new insights into the carcinogenesis and progression of human HCC. It could be assumed that leptin acting as an inhibitor and/or promoter, is involved in the process of carcinogenesis and progress of human HCC.
Chancroid and Haemophilus ducreyi: an update (1995)

Haemophilus ducreyi is a fastidious gram-negative bacillus that causes the sexually transmitted infection chancroid. Chancroid is a major genital ulcerative disease in Africa, Southeast Asia, the Caribbean, and Latin America and is of increasing concern in the United States. Genital ulcerative disease and chancroid in particular have been associated with facilitating the transmission of human immunodeficiency virus. The diagnosis of chancroid based on the clinical appearance of the genital lesion or on the isolation of H. ducreyi on selective medium is relatively insensitive. However, recent advances in nonculture diagnostic tests have enhanced our ability to diagnose chancroid. There has been renewed interest in understanding the pathogenesis of H. ducreyi. In vitro and in vivo models have been developed to help identify important virulence determinants. Through the use of biochemical and molecular techniques, macromolecular components that may be important in virulence have been identified.
An adaptive modal-based active control system (1991)

Active control for silencing sound and vibration has recently become the subject of much investigation, and is now being enhanced by the advent of adaptive filtering techniques. On another front, modal decomposition for active control problems has been shown to offer a number of practical advantages, as independent modal control can: minimize the number of actuators, sensors, and corresponding dimensionality of the controller, as well as minimize the control energy; provide robustness to system parameter uncertainty; and, minimize the adaptive convergence time by uncoupling the modal responses. In this paper, details are sketched for a narrow-band adaptive modal-based active control system that incorporates all of these features. The major topics addressed deal with modal filters, actuator prefilters, spatial sampling effects, and design methodology. Although this work pertains only to the narrow-band disturbance problem, these techniques can be readily generalized to the wideband case by using temporal filters to separate out different spectral bands for narrow-band modal-based processing. The analytical results are illustrated by numerical example for a vibrating cantilever beam, using a graphics display that was developed for real-time interactive design.
A Monolithic 622Mb/s Clock Extraction Data Retiming Circuit (1991)

In high-speed digital transmission systems, a digital waveform must be regenerated to insure data integrity. This is usually done by extracting a clock directly from the input data stream using a non-linear function with a band-pass filter, and then using this clock to trigger a decision circuit which reshapes the data stream. The band-pass filter is typically a SAW filter or PLL. This method is accepted as the norm for systems above 200Mb/s. However, the design of such a system requires careful alignment of the data relative to the clock over temperature, supply variation, process variations, and age. Also, this approach is relatively expensive since the components are difficult to integrate.
Simplified Recruitment Model Using Text-Mining on Psychometric and Aptitude Tests (2018)

In the present day working scenario, job recruitment has become a time-consuming process for the HR department. Not only that, the results of the prevailing recruitment system are often unsatisfactory, as reflected in the frequent job changes, employee dissatisfaction and overall inefficiency. Through the proposed model, we plan to simplify and automate the process with an additional stress of psychometric tests. Psychometric tests prove to be useful in mapping the personality, aptitude and qualities of candidates with the jobs they are applying for. Text mining is performed on the answers, based on a scoring mechanism that serves to produce a shortlist for a given job. This model can work for several recruitment areas and jobs, as need be.
Copper‐Catalyzed Rearrangement of Tertiary Amines through Oxidation of Aliphatic CH Bonds in Air or Oxygen: Direct Synthesis of α‐Amino Acetals (2010)

A surprising turn of events: Mechanistic studies, including trapping, control, and isotope-labeling experiments, led to the proposal of a rearrangement mechanism involving oxidation of aliphatic CH bonds (see scheme; TMEDA=tetramethylethylenediamine).
Proteolytic Enzymes in Inflammation: Rationale for Use (1956)

(1956). Proteolytic Enzymes in Inflammation: Rationale for Use. Postgraduate Medicine: Vol. 19, The Johns Hopkins University School of Medicine and Hospital, pp. 16-22.
Extraction of bowing parameters from violin performance combining motion capture and sensors (2009)

A method is described for measurement of a complete set of bowing parameters in violin performance. Optical motion capture was combined with sensors for accurate measurement of the main bowing parameters (bow position, bow velocity, bow acceleration, bow-bridge distance, and bow force) as well as secondary control parameters (skewness, inclination, and tilt of the bow). In addition, other performance features (moments of on/off in bow-string contact, string played, and bowing direction) were extracted. Detailed descriptions of the calculations of the bowing parameters, features, and calibrations are given. The described system is capable of measuring all bowing parameters without disturbing the player, allowing for detailed studies of musically relevant aspects of bow control and coordination of bowing parameters in bowed-string instrument performance.
From evolution to discourse: Key conceptual debates in the history and study of traumatic stress (2014)

Abstract The study of traumatic stress has a long and rich history, drawing upon many of the major strands of thinking in the discipline of psychology. The article highlights three important sets of debates arising out of the study of traumatic stress, exploring how these debates reflect ongoing dilemmas in the study of extreme stressors and the formulation of their impact on individuals and groups. The three key areas selected for discussion are firstly, the origins or causes of traumatic stress, secondly, understandings of the mechanisms by which people are theorised to become traumatised, and thirdly, the political, cultural and discursive positioning of the construct of traumatic stress. It is argued that research and writing on traumatic stress is reflective of broader tensions in psychology related to addressing concerns about scientific credibility, models of personhood and the social location of human subjects, amongst other issues. The need for integrative, cross-disciplinary and ever evolving scholarship in the area is highlighted.
Theoretical aspects of control of synchronous reluctance machines (1992)

The paper presents a theoretical performance analysis of several control strategies for synchronous reluctance machines which are being fed from a current controlled inverter. The three main control strategies considered have as their objectives to allow maximum rated torque, maximum rate of change of torque and maximum power factor, respectively, from the machine. These control strategies are investigated to determine their limitations and inter-relationships. A technique for ‘field weakened’ control of the machine is developed. It is shown that the rate of change of torque performance of the control strategies based on constant current angle is poor at lower angular velocities. A control strategy based on having constant current in the most inductive axis of the machine is shown to give better performance under these conditions, and a technique for moving between control strategies is developed.