gebhart/patrepeval huggingface dataset:
Oxidized LDL activates STAT1 and STAT3 transcription factors: possible involvement of reactive oxygen species (1999)

The effect of cupric ion‐oxidized low density lipoprotein (Cu‐LDL) or endothelial cell‐oxidized LDL (E‐LDL) on STAT1 and STAT3 (signal transducers and activators of transcription) DNA binding activity was investigated by electrophoretic mobility shift assay in human endothelial cells. Both oxidized LDL enhanced STAT1 and STAT3 binding to their respective consensus binding sites. Furthermore, the activation of STATs was proportional to the oxidation degree of LDL in that the highly oxidized Cu‐LDL exhibited a more marked effect than E‐LDL. Oxidized LDL induced an intracellular oxidative stress, as shown by the increase in the intracellular level of lipid peroxidation products (thiobarbituric acid‐reactive substances) and in the level of reactive oxygen species, measured by the fluorescence of dichlorofluorescein diacetate. The binding activity of STAT1 and STAT3 paralleled these two parameters, which suggests that it is dependent upon the redox state of the cell. The activation of STATs by oxidized LDL was almost completely inhibited by the lipophilic antioxidant vitamin E, and partially antagonized by the hydrophilic thiol‐containing compound N ‐acetylcysteine, suggesting that the oxidative stress induced by oxidized LDL is involved in the observed phenomenon. Furthermore, the lipid extract of Cu‐LDL also activated STAT1 and STAT3. Since the STAT pathway plays a key role in cytokine and growth factor signal transduction, the activation of STATs by oxidized LDL might be related to their proinflammatory and fibroproliferative effect in the atherosclerotic plaque.
Fabrication of Transparent Cerium‐Doped Lutetium Aluminum Garnet Ceramics by Co‐Precipitation Routes (2006)

Nanosized, highly sinterable Ce‐doped lutetium aluminum garnet (LuAG:Ce) powders were synthesized by the urea homogeneous co‐precipitation routes. LuAG:Ce transparent ceramics with an average grain size of about 6 μm were successfully fabricated at 1800°C for 10 h by vacuum sintering without sintering aids using the powders calcined at 1000°C for 2 h. The transmittance in the visible light region reaches 65%. The radioluminescence spectrum displays a broad band located at 480–650 nm consisting of two emissions due to the transitions from the lowest 5 d excited state to the 4 f ground state of Ce 3+ , which is consistent with that of LuAG:Ce single crystal and well coupled with the silicon photodiodes.
Chemical Examination of Wedelia Calendulaceae. IV: Synthetic analogues of wedelolactone (1961)

The syntheses of 7'-methoxy- and 5',7',6-trimethoxy-coumarino(3',4':3,2)coumarones (IIa and IIb) are described.
Dihydroindol-7(6H)-ones and 6,7-Dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione (1990)

3-Methylcyclohexenones may be converted into dihydroindol-7(6H)-ones by conversion of the epoxide into the 2-benzylamino-3-methylcyclohexenone, which reacts with dimethyl- formamide dimethyl acetal to give N-benzyldihydroindol-7(6H)-ones. The limitations of the process are discussed, as is the failure to convert the dihydroindol-7(6H)-ones into dihydropyrroloazepinediones by Beckmann or Schmidt rearrangements. An example of the latter compounds was made by a simple procedure from pyrrolecarboxylic acid.
Effects of prolactin on sleep in cyclic rats (1999)

We previously demonstrated that pregnancy-associated sleep enhancement is correlated with the daily surges of prolactin (PRL). However, in spite of a surge of PRL in the proestrous night, a reduction of nocturnal sleep occurs in phase with proestrus. Therefore, to clarify the physiological role of PRL in sleep regulation during the estrous cycle, time-course changes in sleep were analyzed in bromocriptine (CB-154)-treated and/or PRL-supplemented female rats. Sleep patterns characteristic of proestrus-to-estrus were not affected by the CB-154 treatment. In contrast, nocturnal rapid eye movement sleep (REMS) was significantly increased after the PRL supplementation. The CB-154 treatment diminished the REMS-enhancing effect of PRL. Thus, the results suggest that the endogenous PRL is not crucial for the regulation of sleep during the estrous cycle, while exogenous PRL can enhance REMS.
Research on Security Mechanism of AAA-based Mobile IP (2010)

The security mechanism of AAA-based mobile IP is mainly researched.There are lots of security problems between the mobile IP communication process.An improved scheme by analyzing the proposed IETF AAA-based Mobile IP model is put forward.It can improve the registration efficiency of the mobile IP,enhance the security of the authentication and registration process.The improved scheme can also enhance the security of the communication process after the mobile IP has registered.
Growth and Volatility (2002)

This paper has two objectives. First, to establish empirically a U-shaped relation between GDP growth rate and income volatility. The backward as well as the fast-growing countries have had extensive volatility; but developed nations by contrast have enjoyed much more stable income. Second, to present a macroeconomic model to study how growth and volatility evolve together. The twin endogenous variables are financial liberalization interacting with liquidity constraints. Opening LDC financial markets could raise or lower their long-term income and growth rates, depending on the severity of existing liquidity constraints. Financial liberalization and removing financial market imperfections unambiguously worsen income volatility. (JEL E32, O16)
Clutter rejection using multi-spectral processing (1990)

The DARPA MUSIC program is presently collecting data to support multi-spectral infrared target detection in clutter. The plan of the MUSIC program is discussed first, followed by the theoretical basis of multi-spectral and recursive moving target indicator (RMTI) processing. An example using data from the MUSIC sensor is presented. In this example spectral-spatial processing of two bands is compared to registration and temporal processing of a single band.
Theory of Electrothermal Behavior of Bipolar Transistors: Part II—Two-Finger Devices (2005)

A thorough theoretical and numerical analysis of the electrothermal behavior of two-finger bipolar transistors is presented. It is shown that thermal feedback and coupling effects introduce an additional singularity in the output I-V characteristics, namely a current bifurcation, which manifests itself as multiple solution branches emanating from a branching point. As a result, when the bifurcation condition is reached, the device is triggered in an asymmetrical operation mode in which one device carries most of the current. A unified formulation for the electrothermal behavior of a two-finger device is derived for different bias conditions at the input port: constant voltage, constant base current and constant emitter current. The analysis proofs that the critical condition defining the onset of current bifurcation is the same for all kinds of bias conditions. While operation under a constant base-emitter voltage is limited by the flyback condition, the current bifurcation condition defines the boundary of the normal operation region for the constant base current and constant emitter current cases. Finally, a rigorous method for identifying the conditions of thermal instability for an arbitrary number of emitter fingers is outlined. As an example, the method is used to derive the thermal instability conditions for the general case of temperature dependent thermal conductivity in a two-finger device.
Efficiency of caches for content distribution on the Internet (2010)

Traffic engineering and an economical provisioning of bandwidth is crucial for network providers in times of high competition in broadband access networks. We investigate the efficiency of caching as an option to shorten end-to-end paths and delays while at the same time reducing traffic loads. The portion of HTTP based distribution of cacheable content on the Internet is increasing in recent time. In addition, the favourable effect of Zipf-like access pattern on caches is also confirmed for currently most popular web sites with user generated content. Content delivery (CDN) and peer-to-peer (P2P) networks are distributing a major portion of IP traffic with different impact on caching. P2P traffic is subject to long transport paths although appropriate for caching in principle. CDNs are based on server infrastructures allowing for shorter paths on a global scale on top of network provider platforms. We give a brief overview of the options for deploying caches by content and network providers at different points in the interconnection, backbone or aggregation. The main part of the work focuses on the analysis of replacement strategies with regard to Zipf-like and fixed or slowly varying access pattern. A comparative evaluation shows that least recently used (LRU) essentially differs from caching strategies based on access statistics in terms of the achievable hit rates.
The Army's Future Combat System (FCS): Background and Issues for Congress (2009)

The Future Combat System (FCS) is a multiyear, multibillion dollar program at the heart of the Army's transformation efforts. It is the Army's major research, development, and acquisition program consisting of 14 manned and unmanned systems tied together by an extensive communications and information network. FCS is intended to replace current systems such as the M-1 Abrams tank and the M-2 Bradley infantry fighting vehicle. The FCS program has been characterized by the Army and others as a high-risk venture due to the advanced technologies involved and the challenge of networking all of the FCS subsystems together so that FCSequipped units can function as intended.
Subpopulations of lymphoid and non-lymphoid cells in bronchus-associated lymphoid tissue (BALT) of the mouse. (1988)

Lymphoid and non-lymphoid subpopulations were investigated in the lung of the mouse with immunocyto-, immunohisto- and enzyme-histochemical methods. Special attention was paid to the cell populations in bronchus-associated lymphoid tissue (BALT), which is positioned between a bronchus and an artery. In BALT, discrete T- and B-cell areas can be found. The majority of the T cells belong to the L3T4+ (T-helper) subpopulation. In the T-cell area interdigitating cells can be recognized by anti-class II antibodies as well as by specific monoclonal antibodies, NLDC-145 and MIDC-8. Macrophage subpopulations can be discriminated by location, enzyme reactivity and various macrophage-specific monoclonal antibody markers. On the outer rim of BALT macrophages are recognized by the MOMA-1 and ERTR9 antibody. Macrophages dispersed in BALT can only be discriminated with the MOMA-2 antibody. The macrophage markers F4/80 and Mac-1 show no reactivity in BALT. In lung, tissue macrophages around bronchi and blood vessels are predominantly recognized by the MOMA-1 and MOMA-2 antibody, and a minor population by the ERTR9 antibody. Alveolar macrophages show heterogeneity with the MOMA-1, MOMA-2 and NLDC-145 antibody. The relationship between alveolar macrophages and antigen-presenting cells is discussed here.
Availability of fossil-fired steam power plants. [600 MW and larger] (1977)

Fossil-fired power plants of 600 MW or larger constitute a major proportion of the baseload capacity in the country but have the poorest availability record of any size category. Two primary aims of the EPRI Fossil Plant Performance and Reliability Program are short-term improvement of existing plant reliability, and initiation of work to eliminate current deficiencies in future plants. To define the problems and develop a strategy for improving the availability of over-600 MW fossil-fired plants, the statistics compiled by the EEI have been analyzed, and the resulting conclusions have been supplemented by meeting with utilities which operate power plants in that category. The annual availability reports published by the Edison Electric Institute are based on statistics which aggregate the outage hours from specific failure causes or problem areas. By assigning costs to outages ($4000/hour for forced outages, $1000/hour for scheduled ones), the relative importance of various problem areas has been determined. Boiler tube failures (water tubes, superheater tubes), turbine blade failures, condenser problems, and boiler-feed pump and drive problems have the highest cost impact among the 24 problem areas identified as either ''high cost'' (over $15 million annually) or ''moderately high cost'' ($5 to $15 million annually) calculated according to the approach previously described. To supplement the EEI data, six regional meetings were held by EPRI with utility representatives directly concerned with operating fossil plants of over 600 MW. The informal discussions generally confirmed the relative importance of the problem areas, and provided valuable information on the causes and relationships between problems which statistics alone could not provide.
Molecular dynamics simulation of silicon using empirical tight-binding method (1992)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1992.
Face recognition from multi-pose image sequence (2002)

A novel approach to face recognition based on a multi-pose image sequence is presented in this paper. In this approach, faces are represented by their pattern vectors (projections to eigenfaces) in eigenspace. Instead of recognising a face from a single view, a sequence of images showing face movement (from left to the right profile) is used for recognition. Pattern vectors corresponding to multiple poses build a trajectory in eigenspace where each trajectory belongs to one face sequence (profile to profile). In the training phase, sequences of poses construct prototype trajectories, and in recognition phase, an unknown face trajectory is compared with prototypes. New matching models are presented and analysed as well as the influence of some parameters on the recognition ratio.
Interaction of cattle health/immunity and nutrition. (1999)

The usual means of assessing the health of newly received beef cattle susceptible to bovine respiratory disease (BRD) are subjective, typically involving visual evaluation aided by minimal clinical measurements. Recent evidence based on the occurrence of pneumonic lung lesions at slaughter indicates a need for more accurate methods of diagnosing BRD. Inadequate passive immune transfer at birth may be an important risk factor in susceptibility to BRD, suggesting the need for management to improve passive transfer success rates. Preweaning management and vaccination practices offer opportunities for beef cattle producers to improve the immune status of newly weaned calves and decrease postweaning BRD. Feeding diets with higher levels of concentrate typically improves performance by newly weaned or received cattle, as does feeding diets supplemented with protein; however, limited data suggest that increasing concentrate and protein in receiving diets increases the rate and severity of subjectively determined BRD morbidity. Research with receiving diet concentrate/protein level relative to humoral and cell-mediated immune function coupled with indicators of health and performance is needed. Supplemental B vitamins are sometimes useful in receiving diets, but the effects have been variable, presumably reflecting differences in stress and associated feed intake responses. Vitamin E added to receiving diets to supply > or = 400 IU/animal daily seems beneficial for increasing gain and decreasing BRD morbidity; however, further dose titration experiments are needed. Supplemental Zn, Cu, Se, and Cr can alter immune function of newly received calves, and some field trials have shown decreases in BRD morbidity rate with supplementation; however, several experiments have shown no performance or health/immune benefits from supplementation of these trace minerals. Formulation of receiving diets should take into account decreased feed intake by highly stressed, newly received beef cattle and known nutrient deficiencies, but fortification of such diets with trace minerals beyond the levels needed to compensate for these effects is difficult to justify from present data.
Circulating and Disseminated Tumor Cells in the Management of Breast Cancer (2009)

Despite the advances in early detection and treatment of cancer, patients continue to die of the disease even when they seek care at an early stage. For patients with breast cancer, it is now possible to detect circulating tumor cells (CTCs) in the bloodstream and disseminated tumor cells (DTCs) in the bone marrow by using immunocytochemical and molecular methods. CTCs and DTCs have been found to share similar genotypic and phenotypic characteristics with so-called breast cancer stem cells, a finding that could potentially explain the eventual relapse of disease in a patient previously considered to have been cured by primary therapy. In some studies, the presence of CTCs or DTCs at the time of diagnosis of breast cancer is an independent adverse prognostic variable. However, before CTC/DTC testing can achieve standard-of-care status, there must be improvement in the sensitivity, precision, and reproducibility of the detection methods.
Color-Difference Matches (1971)

For a given pair of colors (i) and (j) of the same brightness, an observer generates in a visual colorimeter a third color (i,j) such that he perceives all three colors to be equally bright and the three differences between them to be of equal size. In color-perception space, the three colors form an equilateral triangle on a surface of constant brightness. The precision of setting the third color (i,j) can be characterized by ellipsoids in color space. Three observers take part in the experiment and over 30 pairs of colors (i) and (j) are presented to them. In approximately 50% of the cases a given observer will agree, within the uncertainty of his own data, with the mean color (i,j) of another observer. The corresponding color-difference-matching ellipses (cross sections of the ellipsoids) of the different observers show a satisfactory correlation. The experimental data presented may be used to test color-difference formulas and the chromaticity spacing in UCS diagrams.
Field effect transistors-from silicon MOSFETs to carbon nanotube FETs (2003)

As CMOS devices scale into the nanometer regime, the material set and device structures employed by conventional FET are beginning to reach their limits. In this paper, device and technology features of CMOS at the nanometer regime are examined. This includes new devices formed by different device structures such as the double-gate FET and back-gate FET, as well as devices made of new materials such as silicon germanium and combinations of new materials such as high-dielectric constant gate dielectrics and metal gate electrodes. Device and materials possibilities beyond silicon CMOS are discussed.
Comparative Catalytic Activity of Group 9 [Cp*M<sup>III</sup>] Complexes: Cobalt‐Catalyzed CH Amidation of Arenes with Dioxazolones as Amidating Reagents (2015)

A procedure for the [Cp*Co(III)]-catalyzed direct C-H amidation of arenes with dioxazolone has been developed. This reaction proceeds under straightforward and mild conditions with a broad range of substrates, including anilides. A comparative study on the catalytic activity of Group 9 [{Cp*MCl2}2] complexes revealed the unique efficiency of the cobalt catalyst.
Scientific Opinion on the substantiation of a health claim related to “toothkind” drinks and reduction of tooth demineralisation pursuant to Article 13(5) of Regulation (EC) No 1924/2006 (2010)

Following an application from GlaxoSmithKline, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim based on newly developed scientific evidence and including a request for the protection of proprietary data related to "toothkind" drinks and reduction of tooth demineralisation. The food constituent, "toothkind" juice drinks, which is the subject of the health claim, is sufficiently characterised. The Panel considers that reduction of tooth demineralisation is a beneficial physiological effect. The applicant identified 25 human intervention trials and 10 in vitro studies as being pertinent to the health claim. In weighing the evidence for reduced potential of "toothkind" juice drinks for demineralisation of dental enamel by reducing plaque pH, the Panel considers that "toothkind" juice drinks reduced tooth demineralisation when compared to sugar solution (10 g/100 ml) at an exposure frequency of seven times daily. No evidence has been presented for an effect at lower exposure frequencies. In weighing the evidence for reduced erosive potential, the Panel considers that "toothkind" juice drinks reduced tooth demineralisation when compared to typical conventional juice drinks at an exposure frequency of four times daily. No evidence has been presented for an effect at lower exposure frequencies. The Panel concludes that a cause and effect relationship has been established between the consumption of "toothkind" juice drinks and reduction of tooth demineralisation when compared to typical conventional juice drinks at an exposure frequency of four times daily and when compared to typical sugar-containing acidic nonalcoholic beverages at an exposure frequency of seven times daily.
PAPNET™ Cytological Screening System (1991)

Journal Article PAPNET™ Cytological Screening System Get access Robert P. De Cresce, MD, MBA, Robert P. De Cresce, MD, MBA Search for other works by this author on: Oxford Academic PubMed Google Scholar Mark S. Lifshitz, MD Mark S. Lifshitz, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 22, Issue 4, 1 April 1991, Pages 276–280, https://doi.org/10.1093/labmed/22.4.276 Published: 01 April 1991
Models of Information Processing in the Brain (2014)

If many computational operations are performed at once, a system can obviously operate faster. However, one part does not know what the other parts are currently doing because the parts operate simultaneously. This causes serious problems of coordination and lateral information transfer from one part of a parallel system to another. These problems have made it hard to program general purpose computers that execute many instructions at once though numerous special purpose systems have been developed for specific tasks.
A Flexible Trust-Based Access Control Mechanism for Security and Privacy Enhancement in Ubiquitous Systems (2007)

It is the ubiquity and mobility absolutely necessary for ubiquitous computing environments that raise new challenges for pervasive service provision invisibly. Particularly, mobility of users/devices causes un-predefined and unpredictable changes in physical location and in available resources and services, event at runtime and during the same service session, thus forcing us to consider very dynamic aspects of evaluation when designing an access control mechanism. Alternatively, there is generally no a priori trust relationship among entities interacting in pervasive computing environments which makes it essential to establish trust from scratch. This task becomes extremely challenging when it is simultaneously necessary to protect the privacy of the users involved. In this paper , we first show how trust evaluation process of the user's system can be based on previous accesses and peer recommendations. A solution then relied on trust to control access is proposed that depends upon pre-defined access control security policy. Several tuning parameters and options are suggested so that end-users can customize to meet the security and privacy requirement of a ubiquitous system.