gebhart/patrepeval huggingface dataset:
Online Frequency and Amplitude Tracking of Nonlinear Non-Stationary Structural Vibration (2009)

This paper presents a sliding-window tracking (SWT) method for accurate tracking of the instantaneous frequency and amplitude of arbitrary dynamic response by processing only three (or more) most recent data points. Teager-Kaiser algorithm (TKA) is a wellknown 4-point method for online tracking of frequency and amplitude. Because finite difference is used in TKA, its accuracy is easily destroyed by measurement and/or signal processing noise. Moreover, because TKA assumes the processed signal to be a pure harmonic, any moving average in the signal can destroy the accuracy of TKA. On the other hand, SWT uses a constant and a pair of windowed regular harmonics to fit the data and estimate the instantaneous frequency and amplitude. Hence, SWT dramatically reduces the influence of any moving average. Moreover, noise filtering is an implicit capability of SWT, and this capability increases with the number of processed points. To compare the accuracy of SWT and TKA, Hilbert-Huang transform (HHT) is used to extract accurate time-varying frequencies and amplitudes by processing the whole data set without assuming the signal to be harmonic. Frequency and amplitude tracking of different amplitude- and frequencymodulated signals, vibrato in music, and nonlinear stationary and non-stationary dynamic signals is studied. Results show that SWT is more accurate, robust, and versatile than TKA for online tracking of frequency and amplitude.
The cycle of SEC4 function in vesicular transport. (1993)

Sec4 is a Ras-like GTP-binding protein required for exocytosis in yeast. Unlike Ras, it is the ability of Sec4 to cycle between the GTP- and GDP-bound forms rather than the absolute levels of the GTP-bound form that is critical for function. This cycle may be coupled to an observed cycle of Sec4 localization within the cell. Sec4 binds to secretory vesicles which then fuse with the plasma membrane in exocytosis. Sec4 can recycle from the plasma membrane through a soluble pool to rebind to a new round of vesicles. We have found an activity in yeast (Saccharomyces cerevisiae) comparable to that of the GDP dissociation inhibitor protein isolated from mammalian cells that releases GDP-bound Sec4 from membranes. DSS4-1, a dominant suppressor of the sec4-8 temperature-sensitive mutation, encodes a nucleotide exchange protein. The cycle of Sec4 may function to allow the assembly and subsequent disassembly of a set of proteins necessary for exocytosis. Candidates for members of this set of proteins are encoded by sec genes which show strong genetic interactions with sec4-8. Two of these (SEC8 and SEC15) encode large proteins which form a complex that is peripherally associated with the plasma membrane.
IGF-I increases IGFBP-5 and collagen α<sub>1</sub>(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells (2004)

IGF-I is a potent fibrogenic growth factor that stimulates proliferation of intestinal smooth muscle cells and increases synthesis of collagen and IGF-I-binding proteins by the cells. These processes contribute to intestinal fibrosis that develops in patients with Crohn's disease and in Lewis-strain rats with experimental Crohn's disease. The aim of this study was to determine which early docking proteins are associated with IGF-I receptor signal transduction and which transduction pathway is involved in IGF-I-mediated gene regulation in intestinal smooth muscle cells. Primary cultures of smooth muscle cells isolated from the muscularis externa of the distal colon of Lewis rats were treated with IGF-I (100 ng/ml). Immunoprecipitation studies demonstrated that IGF-I stimulation resulted in tyrosine phosphorylation of IRS-1, IRS-2, and Shc. Coimmunoprecipitation demonstrated a close association between the IGF-I receptor and these three early docking proteins. Concurrent treatment with the MAPK inhibitor PD98059 (10 μM) resulted in an inhibition of the IGF-I-mediated increase in IGFBP-5 and collagen α 1 (I) mRNAs, while concurrent treatment with the phosphatidylinositol 3-kinase (PI3-K) inhibitor wortmannin (100 nM) had no effect. In additional experiments, cells were transiently transfected with adenoviral vectors dominantly expressing inactive mutant Akt or constitutively expressing wild-type Akt. In both cases, the IGF-I-mediated increase in collagen I protein did not differ from that observed in control cultures that had been transfected with an adenoviral vector carrying the LacZ reporter gene. These results suggest that the MAPK pathway is key to IGF-I-mediated gene regulation in intestinal smooth muscle cells, whereas data do not suggest a role for the Akt-dependent pathway in our system.
Effect of Architecture on the Crystal Morphology of Block Copolymers. Small-Angle X-ray Scattering and Differential Scanning Calorimetry (2002)

The crystal morphology of copolymers was studied via lamellar spacings from small-angle X-ray scattering (SAXS) and enthalpies of fusion and melting temperatures from differential scanning calorimetry (DSC). It was shown that under similar crystallization conditions, lamellar crystals of triblock BEB copolymers are thinner than those of diblock EB and triblock EBE copolymers.
Metabolism of Steroid and Amino Acid Moieties of Conjugated Bile Acids in Man III. CHOLYLTAURINE (TAUROCHOLIC ACID) (1973)

After oral administration of [2,4-(3)H]-cholyl[(35)S]taurine to eight healthy subjects with indwelling nasoduodenal tubes, the specific activity of the cholyl and taurine moieties and the distribution of radioactivity in biliary bile acid and urinary metabolites, as well as total urinary and fecal (35)S and (3)H, were measured at intervals for 4-8 days. Similar measurements were made after [(35)S]taurine was given orally or intravenously or instilled into the distal intestine. The daily fractional turnover rate of the taurine moiety of cholyltaurine was low and similar to that of the cholyl moiety, indicating that deconjugation occurring during enterohepatic cycling was less than half that previously observed for glycine-conjugated bile acids. Some of the cholyl moiety was absorbed but, since reconjugation occurred predominantly with glycine, little reincorporation into the cholyltaurine pool was observed. Some of the taurine moiety was also absorbed intact but entered large taurine pools, and little reincorporation into the cholyltaurine pool was seen. Oral administration of taurine expanded the cholyltaurine pool and induced a decrease in the fractional turnover rate of the cholyl moiety of cholyltaurine, interpreted to indicate a greater reincorporation of the cholyl moiety because of increased reconjugation with taurine. Taurine moiety not absorbed as taurine appeared to be absorbed largely as sulfate which, like taurine, entered large endogenous pools. Little fecal excretion of (35)S occurred. (35)S was excreted in urine as taurine and sulfate, and excretion in the first 24 h (as percentage of administered dose) correlated highly (r = 0.93) with the daily fractional turnover rate of the taurine moiety. When taurine was instilled into the distal intestine, it appeared as such in plasma, but the more distal the site of instillation, the greater the fraction of urinary (35)S present as sulfate. The [(35)S]sulfate appeared to have come from bacterial degradation of [(35)S]taurine because, when [(35)S]taurine was given intravenously, (35)S was excreted in urine chiefly as [(35)S]taurine with little SO(4)=(-)[(35)S] being present.
IL-17A potentiates TNFα-induced secretion from human endothelial cells and alters barrier functions controlling neutrophils rights of passage (2013)

Interleukin-17A (IL-17A) is an important pro-inflammatory cytokine that regulates leukocyte mobilization and recruitment. To better understand how IL-17A controls leukocyte trafficking across capillaries in the peripheral blood circulation, we used primary human dermal microvascular endothelial cells (HDMEC) to investigate their secretory potential and barrier function when activated with IL-17A and TNFα. Activation by TNFα and IL-17A causes phosphorylation of p38 as well as IκBα whereby NFκB subsequently becomes phosphorylated, a mechanism that initiates transcription of adhesion molecules such as E-selectin. Members of the neutrophil-specific GRO-family chemokines were significantly up-regulated upon IL-17A stimulation on the mRNA and protein level, whereas all tested non-neutrophil-specific chemokines remained unchanged in comparison. Moreover, a striking synergistic effect in the induction of granulocyte colony-stimulating factors (G-CSF) was elicited when IL-17A was used in combination with TNFα, and IL-17A was able to significantly augment the levels of TNFα-induced E-selectin and ICAM-1. In accordance with this observation, IL-17A was able to markedly increase TNFα-induced neutrophil adherence to HDMEC monolayers in an in vitro adhesion assay. Using a trans-well migration assay with an HDMEC monolayer as a barrier, we here show that pre-stimulating the endothelial cells with TNFα and IL-17A together enhances the rate of neutrophil transmigration compared to TNFα or IL-17A alone. These results show that IL-17A and TNFα act in cooperation to facilitate neutrophil migration across the endothelial cell barrier. In addition, the synergistic actions of IL-17A with TNFα to secrete G-CSF appear to be important for mobilizing neutrophils from the bone marrow to the blood stream.
SCORe-CT: a new method for testing effectiveness of sulfide-control chemicals used in sewer systems (2011)

A new method for testing the effectiveness of chemical products for sulfide control in sewers is reported. The method, called SCORe-CT (Sewer Corrosion and Odour Research - Chemical Testing), consists of two specially designed laboratory-scale systems that mimic sulfide production in real rising main sewers, and a multi-phase and multi-facet testing protocol. The monitoring tools/methods include both routine chemical analysis of various sulfurous and carbonaceous compounds in liquid and their on-line monitoring using advanced sensors. Molecular methods and microelectrodes can also be employed to examine the microbial structure and activity of sewer biofilms. The SCORe-CT method is not proposed to replace field trials but to screen chemicals prior to their often costly trials/applications in field conditions. For effective chemicals the method helps to reveal the mechanisms involved, and assists with the design of optimal dosage strategies, which would significantly reduce application costs. In this paper, the method is explained in detail and demonstrated with several case studies.
Non-WSSUS vehicular channel characterization in highway and urban scenarios at 5.2 GHz using the local scattering function (2008)

The fading process in high speed vehicular traffic telematic applications at 5 GHz is expected to fulfill the wide-sense stationarity uncorrelated scattering (WSSUS) assumption for very short time-intervals only. In order to test this assumption we apply the concept of a local time– and frequency–variant scattering function, which we estimate from measurements of vehicle-to-vehicle wave propagation channels by means of a multi-window spectrogram. The obtained temporal sequence of local scattering functions (LSF) is used to calculate a collinearity measure. We define the stationarity time as the support of the region where the collinearity exceeds a certain threshold. The stationarity time is the maximum time duration over which the WSSUS assumption is valid. Measurements from an highway with vehicles driving in opposite directions show stationarity times as small as 23 ms whereas vehicles driving in the same direction show stationarity times of 1479 ms.
Epoxy resins modified with elastomers and surface-modified silica nanoparticles (2013)

Epoxy resins are inherently brittle. Thus they are toughened with reactive liquid rubbers or core–shell elastomers. Surface-modified silica nanoparticles, 20 nm in diameter and with a very narrow particle size distribution, are available as concentrates in epoxy resins in industrial quantities since 10 years. Some of the drawbacks of toughening, like lower modulus or a loss in strength can be overcompensated when using nanosilica together with these tougheners. Apparently there exists a synergy as toughness and fatigue performance are increased significantly. In this article the literature published in the last decade is studied with a focus on mechanical properties. Results are compared and the mechanisms responsible for the property improvements are discussed.
Memory and Emotion in the Cognitive Architecture (2011)

This chapter explores issues in memory and affect in connection with possible architectures for artificial cognition. Because memory and emotion are evolutionarily and developmentally rooted in social interdependence, a new understanding of these issues is necessary for the principled design of true intelligent systems. We treat emotion not as an optional extra or as a brief episode of feeling, but as the underlying substrate enabling the formation of social relationships essential for the construction of cognition. We treat memory not as the storage and retrieval of immutable data, but as a continuous process contingent on experience and never fully fixed or immutable. Three converging areas of research are identified that hold some promise for further research: social constructionism, reconsolidation memory theory, and memory models based on the nonlinear dynamics of unstable periodic orbits. We argue that the combination of these ideas offers a potentially more substantive approach to understanding the cognitive architecture. Request access from your librarian to read this chapter's full text.
Aging-Related Bugs in Cloud Computing Software (2012)

Cloud computing is established on advanced software technologies intended to enhance the scalability of computing infrastructure by making full use of commodity servers. The more cloud computing relies on software technologies, the more software bugs have significant impacts on the system availability. Aging-related bugs, which cause the accumulation of errors in long time software execution, often remain even after the release of a stable version of the software. This paper investigates the bug reports of five major open-source software projects related to cloud computing and confirms the issues about the existence of aging-related bugs. From the investigation how the developers work around such aging-related bugs, the importance of the tool assistance for reproducing the aging problem in replicated site is discussed.
Synthesis of potential cholelitholytic agents: 3 alpha,7 alpha,12 alpha-trihydroxy-7 beta-methyl-5 beta-cholanoic acid, 3 alpha,7 beta,12 alpha-trihydroxy-7 alpha-methyl-5 beta-cholanoic acid, and 3 alpha,12 alpha-dihydroxy-7 xi-methyl-5 beta-cholanoic acid. (1985)

This report describes the chemical synthesis of six new bile acid analogs, namely, 3 alpha,7 alpha,12 alpha-trihydroxy-7 beta-methyl-5 beta-cholanoic acid (7 beta-methyl-cholic acid), 3 alpha,7 beta,12 alpha-trihydroxy-7 alpha-methyl-5 beta-cholanoic acid (7 alpha-methyl-ursocholic acid), 3 alpha,12 alpha-dihydroxy-7 xi-methyl-5 beta-cholanoic acid (7 xi-methyl-deoxycholic acid), 3 alpha,12 alpha-dihydroxy-7-methyl-5 beta-chol-7-en-24-oic acid, 3 alpha,12 alpha-dihydroxy-7-methyl-5 beta-chol-6-en-24-oic acid, and 3 alpha,12 alpha-dihydroxy-7-methylene-5 beta-cholan-24-oic acid. The carboxyl group of the starting material 3 alpha,12 alpha-dihydroxy-7-oxo-5 beta-cholanoic acid was protected by conversion to its oxazoline derivative. A Grignard reaction of the bile acid oxazoline with CH3MgI followed by acid hydrolysis gave two epimeric trihydroxy-7-methyl-cholanoic acids and three dehydration products. The latter were purified by silica gel column chromatography and silica gel-AgNO3 column chromatography of their methyl ester derivatives. Catalytic hydrogenation of 3 alpha,12 alpha-dihydroxy-7-methyl-5 beta-chol-6-en-24-oic acid and 3 alpha,12 alpha-dihydroxy-7-methylene-5 beta-cholan-24-oic acid gave 3 alpha,12 alpha-dihydroxy-7 xi-methyl-5 beta-cholanoic acid. The configuration of the 7-methyl groups and the position of the double bonds were assigned by proton nuclear magnetic resonance spectroscopy and the chromatographic and mass spectrometric properties of the new compounds. These compounds were synthesized for the purpose of exploring new and potentially more effective cholelitholytic agents. The hydrophilic bile acids 7 beta-methyl-cholic acid and 7 alpha-methyl-ursocholic acid are of particular interest because they should be resistant to bacterial 7-dehydroxylation.
Studies on the Experimental Chemotherapy for Dermatomycosis and Candidiasis. X (1986)

The mechanism by which propiolic acid (β-naphthyl) methyl ester (PNE) caused an antifungal action on Candida albicans was studied. PNE inhibited the growth of C. albicans, and minimum inhibitory concentration and minimum fungicidal concentration were 6.25μg/ml and 12.5μg/ml, respectively. PNE at concentrations causing an antifungal action strongly inhibited the endogenous respiration, the exogenous respiration utilizing glucose, succinate, citrate and pyruvate, the uptakes of [3H] leucine and [3H] adenine into cells, the incorporation of [3H] leucine into trichloroacetic acid-precipitated fraction and the incorpporation of [3H] adenine into HClO4-precipitated fractions. However, the inhibitory actions of PNE were not observed in cell free system. During the incubation ofC. albicanswith PNE (12.5-25μg/ml), 20-30% of intracellular K+ was leaked, but leakages of protein and 260nm-absorbing materials were not observed. On the electromicroscopic observations, the surface of C. albicans was smooth and, 1 h after the treatment with PNE (12.5μg/ml), that was changed to be rough. After 24 h, big depressiens were found in almost fungi. These results suggcsted that PNE caused a damage in cell membrane ofC.albicansand that, as the results, the leakage of intracellular K+ and decrease in various metabolic functions of C.albicans occurred.
Protocol to evaluate the impact of yoga supplementation on cognitive function in schizophrenia: a randomised controlled trial (2014)

Short term YT is feasible and acceptable to Indian SZ patients. If beneficial effects of YT are detected, it will provide a novel adjunctive cognitive remediation strategy for SZ patients.
Corporate Governance in Banking: The Role of the Board of Directors (2006)

We use a sample of large international commercial banks to test hypotheses on the dual role of boards of directors. We use a suitable econometric model (two step system estimator) to solve the well-known endogeneity problem in corporate governance literature, and demonstrate the empirical and theoretical superiority of system estimator over OLS and within estimators. We find an inverted U-shaped relation between bank performance and board size, and between the proportion of non-executive directors and performance. Our results show that bank board composition and size are related to directors' ability to monitor and advise management, and that larger and not excessively independent boards might prove more efficient in monitoring and advising functions, and create more value. All of these relations hold after we control for the measure of performance, the weight of the banking industry in each country, bank ownership, and regulatory and institutional differences.
CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells (2018)

CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nanobodies that recognize three non-overlapping epitopes of the extracellular domain of CD38. Here, we fused these VHH domains to the hinge, CH2, and CH3 domains of human IgG1, yielding highly soluble chimeric llama/human heavy chain antibodies (hcAbs). We analyzed the capacity of these hcAbs to mediate complement-dependent cytotoxicity (CDC) to CD38-expressing human multiple myeloma and Burkitt lymphoma cell lines. Combinations of two hcAbs that recognize distinct, non-overlapping epitopes of CD38 mediated potent CDC, in contrast to the hcAb monotherapy with only weak CDC capacity. Similarly, combining daratumumab with a hcAb that recognizes a non-overlapping epitope resulted in dramatically enhanced CDC. Further, introducing the E345R HexaBody mutation into the CH3 domain strongly enhanced the CDC potency of hcAbs to CD38-expressing cells. Exploiting their high solubility, we genetically fused two distinct nanobodies into heteromeric dimers via a flexible peptide linker and then fused these nanobody dimers to the hinge, CH2 and CH3 domains of human IgG1, yielding highly soluble, biparatopic hcAbs. These biparatopic hcAbs elicited CDC toward CD38-expressing myeloma cells more effectively than daratumumab. Our results underscore the advantage of nanobodies vs. pairs of VH and VL domains for constructing bispecific antibodies. Moreover, the CD38-specific biparatopic heavy chain antibodies described here represent potential new powerful therapeutics for treatment of multiple myeloma.
<i>Δ</i> 6- and <i>Δ</i>12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (<i>Borago officinalis</i>) (1988)

Microsomal membrane preparations from the maturing cotyledons of common borage (Borago officinalis) exhibit delta 12- and delta 6-desaturase activities, which resulted in the synthesis of linoleate and gamma-linolenate respectively. The desaturase enzymes utilized the complex lipid substrate phosphatidylcholine. The activity of these enzymes was sufficiently high to allow the monitoring of the mass changes in the endogenous oleate, linoleate and gamma-linolenate in the microsomal phosphatidylcholine in the presence of NADH (i.e. under desaturating conditions). The results illustrate that the delta 12-desaturase uses the oleate substrate at both the sn-1 and -2 positions of sn-phosphatidylcholine, whereas the delta 6-desaturase is almost totally restricted to the linoleate at position 2 of the complex lipid. Estimate of the acyl-substrate pool size at position 2 of sn-phosphatidylcholine for both desaturases indicated that some 50% of the oleate and linoleate was available to the enzymes. The microsomes (microsomal fractions) had a somewhat impaired Kennedy [(1961) Fed. Proc. Fed. Am. Soc. Exp. Biol. 20, 934-940] pathway for the formation of triacylglycerols when compared with other oil-rich plant species that have been studied [Stymne & Stobart (1987) The Biochemistry of Plants: a Comprehensive Treatise (Stumpf, P.K., ed.), vol. 10, chapter 8, pp. 175-214, Academic Press, New York]. In the presence of sn-glycerol 3-phosphate and acyl-CoA, large quantities of phosphatidic acid accumulated in the membranes. Acyl-selectivity studies on the glycerol-acylating enzymes showed that gamma-linolenate could be acylated to both the sn-1 and sn-2 positions of sn-glycerol 3-phosphate. However, stereochemical analysis of the acyl components of the sn-triacylglycerol obtained from mature seeds indicated that, whereas no gamma-linolenate was present at the sn-1 position, it accounted for over 50% of the fatty acids at position sn-3. The results indicate that the diacylglycerol acyltransferase (EC 2.3.1.20) may show a strong selectivity for gamma-linolenoyl-CoA and hence result in the efficient removal of this fatty acid from the acyl-CoA pool in vivo, leaving negligible substrate for utilization by the sn-glycerol 3-phosphate acyltransferase (EC 2.3.1.15).