gebhart/patrepeval huggingface dataset:
Accurate Multiresolution Modeling of the Earth's Gravitational Field (2001)

Abstract : The thrust of this project has been two-fold, namely, (1) to improve the performance of existing models of Earth's gravitational field, mainly with respect to speed of evaluation; and (2) to develop new multi resolution estimation techniques to produce new gravitational models. We have constructed two local models of the gravitational field, both of which map the surface of a sphere to the surface of a cube. These models differ in the choice of basis functions. The first uses multi-wavelets to represent the gravitational field at a fixed distance from Earth, and the second model uses B-splines. Both models use polynomial interpolation to compute the variation in height of the gravity field. Significant progress has been made towards implementing a procedure for estimating gravity models directly from physical measurements. We have developed a new estimation algorithm, a multi-resolution rank-revealing QR decomposition. This algorithm produces the 'minimum detail' solution instead of the usual minimum norm solution of the ill-conditioned least squares problem. A basis for bandlimited functions has been constructed using a new method for computing the generalized Gaussian quadratures for exponentials. These bases are closely related to the prolate spheroidal wave functions, and we plan to create the next generation of models for evaluation and estimation of the gravity field using such bases. These bases are nearly optimal in terms of the number of coefficients necessary to represent a bandlimited function.
Mechanisms of P/CAF auto-acetylation (2003)

P/CAF is a histone acetyltransferase enzyme which was originally identified as a CBP/p300-binding protein. In this manuscript we report that human P/CAF is acetylated in vivo. We find that P/CAF is acetylated by itself and by p300 but not by CBP. P/CAF acetylation can be an intra- or intermolecular event. The intermolecular acetylation requires the N-terminal domain of P/CAF. The intramolecular acetylation targets five lysines (416-442) at the P/CAF C-terminus, which are in the nuclear localisation signal (NLS). Finally, we show that acetylation of P/CAF leads to an increment of its histone acetyltransferase (HAT) activity. These findings identify a new post-translation modification on P/CAF which may regulate its function.
Genetic analysis of gene 1.2 of bacteriophage T7: isolation of a mutant of Escherichia coli unable to support the growth of T7 gene 1.2 mutants (1981)

The product of gene 1.2 of bacteriophage T7 is not required for the growth of T7 in wild-type Escherichia coli since deletion mutants lacking the entire gene 1.2 grow normally (Studier et al., J. Mol. Biol. 135:917-937, 1979). By using a T7 strain lacking gene 1.2, we have isolated a mutant of E. coli that was unable to support the growth of both point and deletion mutants defective in gene 1.2. The mutation, optA1, was located at approximately 3.6 min on the E. coli linkage map in the interval between dapD and tonA; optA1 was 92% cotransducible with dapD. By using the optA1 mutant, we have isolated six gene 1.2 point mutants of T7, all of which mapped between positions 15 and 16 on the T7 genetic map. These mutations have also been characterized by DNA sequence analysis, E. coli optA1 cells infected with T7 gene 1.2 mutants were defective in T7 DNA replication; early RNA and protein synthesis proceeded normally. The defect in T7 DNA replication is manifested by a premature cessation of DNA synthesis and degradation of the newly synthesized DNA. The defect was not observed in E. coli opt+ cells infected with T7 gene 1.2 mutants or in E. coli optA1 cells infected with wild-type T7 phage.
Insertional protein engineering for analytical molecular sensing (2006)

The quantitative detection of low analyte concentrations in complex samples is becoming an urgent need in biomedical, food and environmental fields. Biosensors, being hybrid devices composed by a biological receptor and a signal transducer, represent valuable alternatives to non biological analytical instruments because of the high specificity of the biomolecular recognition. The vast range of existing protein ligands enable those macromolecules to be used as efficient receptors to cover a diversity of applications. In addition, appropriate protein engineering approaches enable further improvement of the receptor functioning such as enhancing affinity or specificity in the ligand binding. Recently, several protein-only sensors are being developed, in which either both the receptor and signal transducer are parts of the same protein, or that use the whole cell where the protein is produced as transducer. In both cases, as no further chemical coupling is required, the production process is very convenient. However, protein platforms, being rather rigid, restrict the proper signal transduction that necessarily occurs through ligand-induced conformational changes. In this context, insertional protein engineering offers the possibility to develop new devices, efficiently responding to ligand interaction by dramatic conformational changes, in which the specificity and magnitude of the sensing response can be adjusted up to a convenient level for specific analyte species. In this report we will discuss the major engineering approaches taken for the designing of such instruments as well as the relevant examples of resulting protein-only biosensors.
Association Study of 71 European Crohnʼs Disease Susceptibility Loci in a Japanese Population (2013)

Our study suggests that there is a differential genetic background of CD susceptibility between Japanese and European populations.
Virtual preoperative measurement and surgical manipulation of sagittal spinal alignment using a novel research and educational software program (2010)

Understanding regional as well as global spinal alignment is increasingly recognized as important for the spine surgeon. A novel software program for virtual preoperative measurement and surgical manipulation of sagittal spinal alignment was developed to provide a research and educational tool for spine surgeons. This first-generation software program provides tools to measure sagittal spinal alignment from the occiput to the pelvis, and to allow for virtual surgical manipulation of sagittal spinal alignment. The software was developed in conjunction with Clifton Labs, Inc. Photographs and radiographs were imported into the software program, and a 2D virtual spine was constructed from the images. The software then measured regional and global sagittal spinal alignment from the virtual spine construct, showing the user how to perform the measurements. After measuring alignment, the program allowed for virtual surgical manipulation, simulating surgical procedures such as interbody fusion, facet osteotomy, pedicle subtraction osteotomy, and reduction of spondylolisthesis, as well as allowing for rotation of the pelvis on the hip axis. Following virtual manipulation, the program remeasured regional and global sagittal spinal alignment. Computer software can be used to measure and manipulate sagittal spinal alignment virtually, providing a new research and educational tool. In the future, more comprehensive programs may allow for measurement and interaction in the coronal, axial, and sagittal planes.
539: The Prognostic Value of PCA3 Gene-Based Analysis of Urine Sediments After Extended Digital Rectal Examination (2006)

You have accessJournal of UrologyModerated Poster, Sunday, May 21, 2006, 3:30 - 5:30 pm1 Apr 2006539: The Prognostic Value of PCA3 Gene-Based Analysis of Urine Sediments After Extended Digital Rectal Examination Daphne Hessels, Marlijn P. Van Gils, J. Alfred Witjes, Gees F. Jansen, W. Pim Peelen, Onno Van Hooij, Sander A. Jannink, Suzanne L. Hanssen, Peter F. Mulders, and Jack A. Schalken Daphne HesselsDaphne Hessels More articles by this author , Marlijn P. Van GilsMarlijn P. Van Gils More articles by this author , J. Alfred WitjesJ. Alfred Witjes More articles by this author , Gees F. JansenGees F. Jansen More articles by this author , W. Pim PeelenW. Pim Peelen More articles by this author , Onno Van HooijOnno Van Hooij More articles by this author , Sander A. JanninkSander A. Jannink More articles by this author , Suzanne L. HanssenSuzanne L. Hanssen More articles by this author , Peter F. MuldersPeter F. Mulders More articles by this author , and Jack A. SchalkenJack A. Schalken More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32785-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "539: The Prognostic Value of PCA3 Gene-Based Analysis of Urine Sediments After Extended Digital Rectal Examination." The Journal of Urology, 175(4S), p. 175 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 175 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Daphne Hessels More articles by this author Marlijn P. Van Gils More articles by this author J. Alfred Witjes More articles by this author Gees F. Jansen More articles by this author W. Pim Peelen More articles by this author Onno Van Hooij More articles by this author Sander A. Jannink More articles by this author Suzanne L. Hanssen More articles by this author Peter F. Mulders More articles by this author Jack A. Schalken More articles by this author Expand All Advertisement PDF downloadLoading ...
Real time reconfiguration of wearable antennas (2011)

Wearable antennas (WAs) are critical to communication among in, on, or off-body devices, and have been designed for a variety of frequency and radiation requirements. However, various factors, such as position and orientation of body, etc., can affect the antenna performance drastically, and consequently cause undesirable radiation behavior. This paper aims at offering a practical solution to the real-time design of WAs for telemedicine. Due to flexibility and high convergence speed of Particle Swarm Optimization (PSO) algorithms, modified binary PSO is utilized to reconfigure a proposed WA in order to maintain resonance at 2.45GHz at different bend angles.
<title>Temperature-insensitive long-period gratings for strain and refractive index sensing</title> (1997)

Long-period gratings have recently been demonstrated as highly versatile strain, temperature and refractive index sensors that can be implemented with simple demodulation schemes. The cross-sensitivity of long-period gratings to ambient temperature variations can be a limiting factor in applications that require their use as strain or refractive index sensors. The thermal-induced spectral shift in the grating transmission spectrum can be attributed to the material and waveguide changes in the grating characteristics. By designing special optical fiber refractive index profiles, these two effects can be counter- balanced to produce gratings that have an order of magnitude smaller temperature wavelength shift than conventional long- period gratings. We present experimental results for strain and refractive index sensors using these temperature insensitive long-period gratings. Such transducers are shown to possess strain- and refractive index-induced wavelength shifts that are comparable to those of standard gratings. The cross-sensitivity to temperature is determined at different magnitudes of strain and ambient index to determine the effectiveness of these gratings in practical applications.
Assessment of estrogen receptor distribution in human endometrium by direct immunofluorescence (1995)

These findings indicate that the fluorescein labeled anti-idiotypic antibody can be used to detect ER in normal and pathological human endometrium and to monitor changes in ER expression in the endometrium during hormonal therapy.
Successful treatment of epilepsy by resection of periventricular nodular heterotopia. (2012)

We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy.
Analysis and space-vector-modulation of a 4L-3B6-VSC (2013)

This paper discusses the circuit of a 4L-3B6-VSC and presents the switching states and the output voltage quality of the converter. Furthermore a Space-Vector-Modulation scheme is introduced and the semiconductor losses and its distribution are considered for a 1300V 4L-3B6-VSC with 500kVA. Finally the paper describes a capacitor voltage balancing scheme and its influence on the output voltage quality.
Heterotopic ileal pancreas with lipoma and coexisting fibromatosis associated with a rare case of gastrointestinal bleeding. A case report and review of the literature. (2008)

Ileal heterotopic pancreas is a rare entity with potentially life-threatening complications, local excision being the appropriate indicated treatment.
Probing gas-surface potential energy surfaces with diffraction of hydrogen molecules (2002)

We review recent experiments where diffraction of deuterium molecules from single-crystal surfaces was employed to characterize the potential energy surface for hydrogen dissociative chemisorption. Scattering experiments were carried out on Cu(001), which is the prototype of a system with a high barrier for dissociative chemisorption, on Ni(110), which is the prototype of a system with a low barrier, and on NiAl(110), which is the prototype of an alloy surface with a high barrier. The experiments were carried out on two different set-ups at incident energies between about 20 and 250 meV. Elastic and rotationally inelastic diffraction (RID) peaks were observed in all experiments. Diffraction probabilities are presented and compared for each surface. Elastic diffraction intensities were interpreted with a simple corrugated hard-wall scattering potential. The values of the corrugation are h = 0.075 Å for D2/Cu(001), and h = 0.091 Å for D2/Ni(110). A satisfactory fit of the diffraction intensities could be obtained for D2/NiAl(110) only over a very limited range of incident beam energies. A major finding of our experiments is that dissociative chemisorption strongly affects RID probabilities. These are higher by about a factor of 3-5 for scattering from Ni(110) than for the high-barrier systems Cu(001) and NiAl(110). The high rotational transition probability for systems with low barrier is interpreted as a consequence of the angular anisotropy of the chemisorption potential. Perspectives for future experiments are discussed.
Gel retardation analysis of<i>E.coli</i>M1 RNA-tRNA complexes (1993)

We have analyzed complexes between tRNA and E. coli M1 RNA by electrophoresis in non-denaturing polyacrylamide gels. The RNA subunit of E. coli RNase P formed a specific complex with mature tRNA molecules. A derivative of the tRNA(Gly), endowed with the intron of yeast tRNA(ile) (60 nt), was employed to improve separation of complexed and unbound M1 RNA. Binding assays with tRNA(Gly) and intron-tRNA(Gly) as well as analysis of intron-tRNA/M1 RNA complexes on denaturing gels showed that one tRNA is bound per molecule of M1 RNA. A tRNA carrying a truncation as small as the 5'-nucleotide had a strongly reduced affinity to M1 RNA and was also a weak competitor in the cleavage reaction, suggesting that nucleotide +1 is a major determinant of tRNA recognition and that the thermodynamically stable tRNA-M1 RNA complex is relevant for enzyme function. Binding was shown to be dependent on the M1 RNA concentration in a cooperative fashion. Only a fraction of M1 RNAs (50-60%) readily formed a complex with intron-tRNA(Gly), indicating that distinct conformational subpopulations of M1 RNA may exist. Formation of the M1 RNA-tRNA(Gly), complex was very similar at 100 mM Mg++ and Ca++, corroborating earlier data that Ca++ is competent in promoting M1 RNA folding and tRNA binding. Determination of apparent equilibrium constants (app Kd) for tRNA(Gly) as a function of the Mg++ concentration supports an uptake of at least two additional Mg++ ions upon complex formation. At 20-30 mM Mg++, highest cleavage rates but strongly reduced complex formation were observed. This indicates that tight binding of the tRNA to the catalytic RNA at higher magnesium concentrations retards product release and therefore substrate turnover.
Nanofiber composite membranes with low equivalent weight perfluorosulfonic acid polymers (2010)

Two low equivalent weight perfluorosulfonic acid (PFSA) polymers (825 EW and 733 EW) were successfully electrospun into nanofibers by adding as little as 0.3 wt% of high molecular weight poly(ethylene oxide) as a carrier polymer. The electrospun fiber morphology transitioned from cylindrical filaments to flat ribbons as the total concentration of PFSA + carrier in solution increased from 5 wt% to 30 wt%. PFSA nanofiber mats were transformed into defect-free dense membranes using a four-step procedure: (i) annealing the PFSA polymer during which time intersecting fibers were welded to one another at cross points (ii) mechanically compacting the mats to increase the volume fraction of nanofibers to ∼75%, (iii) imbibing an inert polymer, Norland Optical Adhesive (NOA) 63, into the mats (to fill entirely the void space between nanofibers) and then crosslinking the NOA with UV light, and (iv) removing the poly(ethylene oxide) carrier polymer by boiling the membrane in 1.0 M H2SO4 and then in deionized water. The resulting membranes exhibited higher proton conductivities than that of commercial Nafion 212 membrane (0.16 S/cm at 80 °C and 80% relative humidity and 0.048 S/cm at 80 °C and 50% relative humidity for a membrane with 733 EW nanofibers), with low water swelling (liquid water swelling of 18% for membrane with high conductivity). The proton conductivity of both EW nanofiber composite membranes increased linearly with the PFSA nanofiber volume fraction, whereas gravimetric water swelling was less than expected, based on the volume fraction of ionomer. There was a significantly improvement in the mechanical properties of the nanofiber composite membranes, as compared to recast homogeneous PFSA films.
Enantioselective Synthesis of (-)-(7a<i>S</i>)-2,3,7,7a-Tetrahydro-7a- phenylthio-1<i>H</i>-indene-1,5(6<i>H</i>)-dione and (+)-(8a<i>S</i>)-3,4,8,8a-Tetrahydro-8a-phenylthio-1,6(2<i>H</i>,7<i>H</i>)-naphthalenedione (1989)

Application of the Hajos-Parrish asymetrically biased aldol condensation to 2-(3-oxobutyl)-2-phenylthio-1,3-cyclopentanedione (5a) or 2-(3-oxobutyl) -2-phenylthio-1,3-cyclohexanedione (5b) using (R)-(+)-proline provided (-)-(7aS)-2,3,7,7a-tetrahydro-7a-phenylthio-1H-indene -1,5(6H)-dione (7a) and (+)-(8aS)-3,4,8,8a-tetrahydro-8a -phenylthio-1,6(2H,7H)-naphthalenedione (7b), respectively, in ≥ 95% enantiomeric excess, as determined by 1H-NMR analysis using tris[3-heptafluoropropylhydroxymethylene)-(+)-camphorato]europium(III).
Atomic Layer Deposition of Localized Boron- and Hydrogen-Doped Aluminum Oxide Using Trimethyl Borate as a Dopant Precursor (2020)

Atomic layer deposition (ALD) of boron-containing films has been mainly studied for use in two-dimensional materials and for B doping of Si. Furthermore, lithium-containing borates show great promise as solid electrolyte coatings for enhanced energy storage. In this work, we examine trimethyl borate (TMB) in combination with O2 plasma as a precursor for ALD of B-containing films, targeting the growth of B2O3. It is found that after initial growth on a SiO2 or Al2O3 surface, a rapid decrease in the rate of growth during subsequent ALD cycles occurs, indicating surface inhibition during continued growth. Density functional theory (DFT) cluster calculations in combination with in situ Fourier transform infrared spectroscopy (FTIR) demonstrated that the growth is governed by two different mechanisms depending on the Lewis acidity of the surface: chemisorption on an Al–OH- and Si–OH-terminated surface and physisorption on more acidic B–OH surface sites. The growth could be maintained in a mixed process, by reactivating the surface through single exposures to trimethyl aluminum (TMA) and O2 plasma and thus resetting the surface to Al–OH, on which TMB chemisorption is energetically more favorable. Surprisingly, this process did not result in B2O3 (or Al-doped B2O3) films but instead in B- and H-doped Al2O3 films. Moreover, rather than a uniform boron distribution, the Al2O3 films grown from this process contain a large amount of hydrogen, up to 17 at. % under certain processing conditions, and displayed non-uniform depth distributions of boron and hydrogen with a degree of control over the doping distribution based on the deposition conditions. Finally, the mechanism for the atypical growth mode is proposed on the basis of in situ FTIR and ellipsometry measurements and DFT calculations and was attributed to subsurface reactions of the TMA with the B–OH films grown by TMB–O2 plasma. This makes the process an interesting, albeit atypical, ALD process that allows for a quasi-continuous tuning of the B concentration in the top region of high-purity Al2O3 films.
DRUG EFFECTS ON RESPONDING MAINTAINED BY STIMULUS‐REINFORCER AND RESPONSE‐REINFORCER CONTINGENCIES (1978)

The effects of pentobarbital and d-amphetamine were assessed on key pecking by pigeons under conventional single-key multiple schedules and under two-key multiple schedules in which discriminative stimuli appeared on one key (stimulus key) while pecks on a second key (constant key) produced food. Pecks on the stimulus key had no scheduled consequences. A 60-second variable-interval schedule operated in one component of each multiple schedule: either extinction or a 60-second variable-time schedule operated in the alternate component. When the alternate-component schedule was extinction, a high rate of responding was maintained in the variable-interval component of the single-key schedule; responding on both keys was maintained in the variable-interval component of the two-key schedule. Pentobarbital increased responding in the variable-interval component of the single-key schedule and increased stimulus-key, but not constant-key responding in that component of the two-key schedule. When the alternate-component schedule was changed to variable time, responding declined in the variable-interval component of the single-key schedule; stimulus-key responding was no longer maintained under the two-key schedule. Pentobarbital decreased responding in the variable-interval component of both schedules. With an exception, d-amphetamine only decreased responding in the variable-interval component of the single- and two-key schedules both when the alternate-component schedule was extinction and when it was variable time. The results suggest that the effects of pentobarbital, but not d-amphetamine, depend on the nature of the contingency (stimulus-reinforcer, response-reinforcer) that maintains responding.