gebhart/patrepeval huggingface dataset:
Effect of phenytoin and nifedipine on collagen gene expression in human gingival fibroblasts (1990)

Phenytoin (PHT), a widely used anticonvulsant, and nifedipine (NF), an anti-anginal drug, cause clinically similar gingival overgrowths in some patients. The aim of this work was to investigate their effects on collagen and protein synthesis and cellular proliferation in normal human gingival fibroblasts in vitro. Gingival fibroblasts were cultured from biopsies taken from three healthy individuals during operations on maxillary canines and incubated with various concentrations of NF (100 and 200 ng/ml) and PHT (5 and 10 micrograms/ml) for up to 7 days. The results showed that NF and PHT have a specific effect in reducing total protein and collagen synthesis but do not influence cell proliferation in healthy gingival fibroblasts in vitro. In addition the level of mRNA for type I collagen was decreased after incubation of the cells with the drugs for 1 or 2 days. The decrease in the level of type I collagen mRNA seemed to be specific since the level of type IV collagenase mRNA used as a reference RNA did not decrease.
A Novel Bioabsorbable Gel Formed from a Mixed Micelle Solution of Poly(oxyethylene)‐<i>block</i>‐poly(<scp>L</scp>‐lactide) and Poly(oxyethylene)‐<i>block‐</i>poly(<scp>D</scp>‐lactide) by Concomitant Stereocomplexation and Chain Extension (2013)

Abstract Furan‐terminated poly(oxyethylene)‐ block ‐poly(L‐lactide) (MePEG‐PLLA‐F) and poly(oxyethylene)‐ block ‐poly(D‐lactide) (MePEG‐PDLA‐F) are synthesized by ring‐opening polymerization of L‐ and D‐lactides, respectively, in the presence of poly(ethylene glycol) monomethyl ether (MePEG) and the following terminal reaction with furfuryl isocyanate. Their mixed micelle solution turns to gel quickly with stereocomplexation of the enantiomeric PLLA and PDLA. When 1,8‐bis(maleimido)diethylene glycol (BMG) is added to the mixed micelle solution, the gelation is promoted by the terminal coupling of the copolymers driven by the Diels–Alder reaction of the furanyl groups and BMG giving a gel having higher strength. magnified image
Task Assignment and Trajectory Planning Algorithm for a Class of Cooperative Agricultural Robots (2014)

Agricultural field operations, such as harvesting for fruits and scouting for disease, are labor intensive and time consuming. With the recent push toward autonomous farming, a method to rapidly generate trajectories for a group of cooperative agricultural robots becomes necessary. The challenging aspect of solving this problem is to satisfy realistic constraints such as changing environments, actuation limitations, nonlinear heterogeneous dynamics, conflict resolution, and formation reconfigurations. In this paper, a hierarchical decision making and trajectory planning method is studied for a group of agricultural robots cooperatively conducting certain farming task such as citrus harvesting. Within the algorithm framework, there are two main parts (cooperative level and individual level): (1) in the cooperative level, once a discrete reconfiguration event is confirmed and replanning is triggered, all the possible formation configurations and associated robot locations for specific farming tasks will be evaluated and ranked according to the feasibility condition and the cooperative level performance index; and (2) in the individual level, a local pursuit (LP) strategy based cooperative trajectory planning algorithm is designed to generate local optimal cooperative trajectories for agricultural robots to achieve and maintain their desired operation formation in a decentralized manner. The capabilities of the proposed method are demonstrated in a citrus harvesting problem.
Integrated optics interferometer for high precision displacement measurement (2017)

We present the design and fabrication aspects of an integrated optics interferometer used in the optical head of a compact and lightweight displacement sensor developed for spatial applications. The process for fabricating the waveguides of the optical chip is a double thermal ion exchange of silver and sodium in a silicate glass. This two step process is adapted for the fabrication of high numerical aperture buried waveguides having negligible losses for bending radius as low as 10 mm. The optical head of the sensor is composed of a reference arm, a sensing arm and an interferometer which generates a one dimensional fringe pattern allowing a multiphase detection. Four waveguides placed at the output of the interferometer deliver four ideally 90 phase shifted signals.
Aromatic Cyclodehydrogenation. V. A Synthesis of Fluoranthene<sup>1</sup> (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAromatic Cyclodehydrogenation. V. A Synthesis of Fluoranthene1Milton Orchin and Leslie ReggelCite this: J. Am. Chem. Soc. 1947, 69, 3, 505–509Publication Date (Print):March 1, 1947Publication History Published online1 May 2002Published inissue 1 March 1947https://pubs.acs.org/doi/10.1021/ja01195a009https://doi.org/10.1021/ja01195a009research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Estudo da restrição de juntas na soldagem de aço inoxidável duplex e dos efeitos na microestrutura, microdureza e tenacidade (2010)

Os acos inoxidaveis duplex apresentam em sua microestrutura ferrita e austenita, de modo a aliar boas
propriedades mecânicas e resistencia a corrosao. Estes materiais possuem um vasto campo de aplicacao na industria
quimica e petroquimica, sendo o AID UNS S31803 um dos mais conhecidos comercialmente. De forma geral, a
soldagem e utilizada para o reparo e manutencao dos equipamentos, sendo que muitas vezes o processo por eletrodo
revestido e bastante utilizado. Existem poucos trabalhos referentes ao estudo da influencia do nivel de restricao da
junta na precipitacao de austenita Widmanstatten. Logo, este trabalho tem como objetivo analisar a influencia da
restricao da junta no balanceamento de fases, na morfologia da austenita precipitada, na microdureza e na tenacidade
da Zona Afetada pelo Calor (ZAC) e da Zona Fundida (ZF). Foram realizadas soldagens em juntas tipo V no aco
inoxidavel duplex UNS S31803 utilizando eletrodo revestido AWS E2209-17. Foram realizadas soldagens em dois
niveis de energia: C1 (15 kJ/cm) e C2 (20 kJ/cm), com e sem restricao. A energia utilizada para a deposicao do passe
de raiz foi de 5 kJ/cm. Foi feito um aumento gradual da temperatura de interpasse com os passes depositados. De
maneira geral, houve maior quantidade de ferrita nos passes de acabamento em relacao aos passes de enchimento e
de raiz. Foram observadas maiores quantidades de austenita Widmanstatten nas condicoes soldadas com restricao. De
forma geral, a ZAC apresentou uma microestrutura mais grosseira nos passes de acabamento, de modo que nao houve
diferencas significativas quando comparadas as condicoes com e sem restricao. Em relacao a microdureza, foram
observados menores niveis nas condicoes que apresentaram maior quantidade de Widmanstatten. Nao foram
observadas diferencas na energia absorvida na ZAC e ZF, comparando as condicoes com restricao e sem restricao.
Activation of NF‐kB1 by OX40 contributes to antigen‐driven T cell expansion and survival (2008)

The costimulatory molecule OX40 (CD134) is strongly required in many instances for effective T cell‐mediated immunity, controlling proliferation and survival of T cells after encountering specific antigen. We previously found that the functional targets of OX40 are survivin and aurora B that regulate proliferation, and Bcl‐2 anti‐apoptotic family members that regulate survival. However, the intracellular pathways from OX40 that mediate these effects are unclear. Here, we show that OX40 signaling can target the canonical NF‐kB (NF‐kB1) pathway in peripheral antigen‐responding CD4 T cells. Phosphorylation of IkBalpha which leads to NF‐kB1 (p50)/RelA nuclear translocation is impaired in OX40‐deficient T cells. Retroviral transduction of active IKKbeta that constitutively activates NF‐kB1 rescues the poor proliferation and survival of OX40‐deficient T cells, directly correlating with increased expression and activity of survivin, aurora B, and Bcl‐2 family members. Moreover, active IKKbeta expression alone is sufficient to restore the defective proliferation and survival of OX40‐deficient T cells in vivo when responding to antigen. Thus, OX40 signals regulate T cell number and viability through the NF‐kB1 pathway that controls expression and activity of intracellular targets for proliferation and survival.
Linear transformation converter and its application to the synthesis of nonlinear networks (1970)

A generalized approach for synthesizing a prescribed resistive nonlinear n-port is presented with the help of a linear 2nport called the linear transformation converter (LTC). It is proved that a large class of voltage-controlled (current-controlled) resistive nports can be realized by using only one LTC and an appropriate homeomorphic nonlinear n-port. The LTC is shown to be decomposable into the cascade connection of a"rotator," "reflector," and "scalor." This factorization provides not only a general realization technique, but also a geometrical interpretation of the capabilities of the 2-port LTC to transform a monotonic characteristic curve into a prescribed multivalued curve. In particular, necessary and sufficient conditions are given for realizing a multivalued two-terminal resistor by connecting an appropriate monotonic resistor across port 2 of a 2-port LTC.
A novel aza-anthrapyrazole modulates the development of CD4+ effector T cells (P5207) (2013)

Abstract BBR3378 is a novel aza-anthrapyrazole that antagonizes autoimmunity and the progression of MOG-induced EAE without the complications noted with anthracycline-based (mitoxantrone) therapy in EAE and human multiple sclerosis. Mitoxantrone induces cell death in rapidly proliferating cells and significant lymphopenia in vivo; however, while most splenic CD4+ cells take up BBR3378 in vivo, only a few are deleted. Moreover, increased dosages of BBR3378 were associated with improved therapeutic impact without concomitant increases in lymphopenia. To determine if BBR3378-mediates regulation of EAE via lymphocyte deletion, splenic T cells were stimulated with anti-CD3 in the presence of low-dose BBR3378 or mitoxantrone. The CD3 blasts showed increased expression of CD25 and CD69, but the enhanced CD4 expression (CD4hi) typically associated with Th progressison to "effector" status was blocked on BBR3378 and mitoxantrone-treated cells, leading to enrichment of slowly proliferating CD4lo-CD69hi T cells. Cytokine production was confined to CD4hi-CD69hi blasts; however, in contrast to mitoxantrone, IL-17 and IFN-gamma production were significantly reduced in the BBR3378-treated cells in the absence of Th cell death. These findings suggest that BBR3378 can regulate specific genes in viable Th cells while impeding the progression of naïve Th cells to full effector status. The Th subsets associated with the induction of EAE were particularly sensitive to BBR3378-mediated suppression.
Spectrum and energy levels of ten-times ionized yttrium (Y xi) (1979)

The spectrum of Y xi was observed with a low-inductance vacuum spark and a laser-produced plasma in the region from 70 to 630 Å on the 10.7-m grazing-incidence spectrograph at NBS. From the identification of 40 lines, a system of 29 energy levels was determined. The level system (Cu ii isoelectronic sequence, 3d10nl) includes the series ns (n=4 –7), np (n=4–6), nd (n=4–6), nf (n =4 – 7), and ng (n =5–8). The 4f2F term is inverted. The observed energy levels are compared with Hartree-Fock calculations. The ionization energy is determined from the ng series (n =5 – 8) to be 1 660 000 ± 200 cm−1 (205.82 ± 0.03 eV).
Mechanisms of Proteinuria in Diabetic Nephropathy II: A Study of the Size-Selective Glomerular Filtration Barrier (1983)

We evaluated the size-selective properties of the glomerular barrier in 30 patients in whom diabetic nephropathy was associated with urinary IgG losses. Neutral dextrans of graded size were used to characterize glomerular membrane-pore structure. A fractional IgG clearance (relative to freely permeable inulin) smaller or greater than 0.001 was used to distinguish patients with minor (group 1, N = 14) and major (group 2, N = 16) urinary IgG leakage, respectively. Fractional clearances of dextrans (theta D) of smaller size (radii 20-40 A) were similar, but those of larger dextrans (radii 42-60 A) were elevated in group 2 relative to group 1 patients. When plotted on log-normal probability coordinates, the correlation between theta D and radius in healthy subjects is linear, suggesting that glomerular pores form one population with a normal distribution. In diabetic nephropathy with urinary IgG leakage, however, theta D for large molecules was elevated and departed from linearity, suggesting a bimodal pore size distribution within the glomerular membrane. A pore model of solute transport revealed (1) the upper pore mode was highly permeable to large dextrans equivalent in size to IgG and (2) the fraction of glomerular filtrate permeating the large pores was greater in group 2 than in group 1 patients with diabetic nephropathy, 6% versus 3%, respectively. We conclude that urinary IgG leakage in diabetic nephropathy is determined by the development of a subpopulation of enlarged pores. The magnitude of urinary IgG losses appears to be a function of the membrane area-fraction occupied by the enlarged pores.
NEUTRALIZATION OF THE AGENT CAUSING LEUKOSIS AND SARCOMA OF FOWLS BY RABBIT ANTISERA (1941)

Neutralizing antibodies against fowl tumor agents can be produced in rabbits by injection of heavy materials obtained from chicken tumor. Similar sediments from normal chicken spleen produce no neutralizing antibodies. The complement-fixing antibodies produced by both materials are unrelated to the neutralizing antibodies.
Bacterial Cellulose-based Biomimetic Composites (2010)

Microbial cellulose has proven to be a remarkably versatile biomaterial and can be used in a wide variety of fields, to produce for instance paper products, electronics, acoustics, and biomedical devices. Various biodegradable and biocompatible polymeric materials have recently been investigated to fabricate inorganic-organic hybrid composites by mimicking the mineralization system of natural bone, with some successful outcomes. However, the search for an ideal biomaterial with properties and functionalities similar to natural bone is a continuing process because no single material can satisfy all the requirements for creating optimal scaffolding properties, such as strength, toughness, osteoconductivity, osteoinductivity, controlled degradation, inflammatory response, and deformability. In this study, the ultrafine 3-D BC network structure with its native unique properties is exploited for the synthesis of materials analogous to natural bone. Our study showed that the formation of apatite is dependent on the presence and type of surface functional groups in the microfibrillar BC network. Degradation of BC has not been fully evaluated in in vitro and in vivo settings. Other cellulose-based materials have however shown limited degradation. Although the complete degradability of materials for tissue engineering applications is very attractive, it is difficult to practically optimize and synchronize the degradation time and mechanical properties of the materials. Modification of BC by incorporation of lysozyme (an enzyme with antibacterial action that is found in body fluids, saliva, sweat and tears) susceptible sugars such as analogues of N-acetylglucosamine (GlcNAc) was performed during microbial synthesis. In addition, GlcNAc shares the structure of some repeated disaccharide units of glycosaminoglycans, which are essential components of extracellular matrices. It is expected that the incorporation of GlcNAc will make BC more degradable and more relevant for end use, for instance in the biomedical area. Subtle changes were observed in the formation of apatite deposits on various BC-GlcNAc surfaces. However, the GlcNAc content of the BCGlcNAc produced was low (0.36 mole%) compared to other studies (4-18 mole%). The bacterial strain used in our study is different from those reported by others. It is possible that the type of cellulose producing strain influences the incorporation of GlcNAc in BC. This observation suggests that it is worth pursuing this type of investigations to tailor the surface properties of BC to meet the main criteria of mineralized collagen composites such as natural bone and teeth. Such investigations should be complemented by in vitro and in vivo degradation studies. Since BC is an environmentally friendly biopolymer, its use for materials fabrication for a broad range of applications can be envisaged as an alternative to forest resources. A limitation however is the large-scale production of BC-based composites.
Acid-catalysed synthesis of a new class of calix[4]arenes (1994)

G. Sartori, R. Maggi, F. Bigi, A. Arduini, A. Pastorio and C. Porta, J. Chem. Soc., Perkin Trans. 1, 1994, 1657 DOI: 10.1039/P19940001657
Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma (2016)

Our integrative approaches led to a catalogue of SE-associated master regulators and oncogenic transcripts, which may significantly promote both the understanding of OSCC biology and the development of more innovative therapies.
Editorial Comment (1980)

No AccessJournal of Urology1 Apr 1980Editorial Comment F. Brantley Scott F. Brantley ScottF. Brantley Scott More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)55994-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 123(4), p. 511 © 1980 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 123Issue 4April 1980Page: 511 Advertisement Copyright & Permissions© 1980 by The American Urological Association Education and Research, Inc.MetricsAuthor Information F. Brantley Scott More articles by this author Expand All Advertisement PDF downloadLoading ...
Characterizing fractured rock aquifers using heated Distributed Fiber-Optic Temperature Sensing to determine borehole vertical flow (2013)

International audience
Phase Diagrams of the Titanium-Aluminum, Titanium-Chromium-Iron, and Titanium-Oxygen Alloy Systems (1952)

Abstract : Paftial phase diagrams are presented for the systems titanium-aluminum, titanium-chromium, titanium-iron, titanium-chromium-iron, and titanium-oxygen. All studies are completed except for the titanium-chromium-iron system, which requires further confirmatory work in certain areas.
Malaria-specific metabolite hemozoin mediates the release of several potent endogenous pyrogens (TNF, MIP-1 alpha, and MIP-1 beta) in vitro, and altered thermoregulation in vivo. (1995)

A characteristic feature of malaria infection is the occurrence of periodic bouts of fever. Experimental and clinical studies have strongly implicated inflammatory cytokines, like tumour necrosis factor (TNF), in the induction of these intermittent fevers [Clark et al., Infect Immunol 32:1058-1066, 1981; Clark et al., Am J Pathol 129:192-199, 1987; Karunaweera et al., Proc Natl Acad Sci USA 89:3200-3203, 1992], but the malaria-specific metabolite(s) which induce the production of such endogenous pyrogens have not yet been fully characterized. It is well known that during the course of malaria infection, a unique schizont component, alternatively referred to as "malaria pigment" or hemozoin, is released along with merozoites as the host erythrocyte bursts [Urquhart, Clin Infect Dis 19:117-131, 1994]. We have recently determined that the core structure of hemozoin comprises a novel insoluble polymer of heme units linked by iron-carboxylate bonds [Slater et al., Proc Natl Acad Sci USA 88:325-329, 1991; Slater et al., Nature 355:167-169, 1992]. We now report that purified native, as well as chemically synthesized, hemozoin crystals potently induce the release of several pyrogenic cytokines, including TNF, MIP-1 alpha, and MIP-1 beta, from murine macrophages and human peripheral blood monocytes in vitro. Also, intravenous administration of chemically synthesized preparations of hemozoin to anaesthetized rats results in a marked drop in body temperature. A similar drop in body temperature is observed following the intravenous injection of other well-characterized pyrogenic cytokines (e.g., TNF) which are known to induce a fever response in awake animals, and is thought to reflect the inability of rats to appropriately regulate their body temperature while anaesthetized. As a consequence of its ability to induce pyrogenic cytokines in vitro, and thermal dysregulation in vivo, we propose that this unique parasite metabolite is an important pyrogen released by malaria parasites at schizogomy, which acts by eliciting the production of a group of potent endogenous pyrogens, which include MIP-1 alpha and MIP-1 beta, as well as TNF, in macrophages.
Thermal Tests of Target Materials for Nuclear Reaction-Based Interrogation Sources (2009)

Compact active interrogation sources are being developed that use low‐energy (kilovolt) nuclear reactions to produce high‐energy (megavolt) neutrons or gamma‐rays. We are evaluating target materials for these interrogation sources by performing rapid thermal load and high power density tests that reach conditions expected during source operation. Following the tests, the targets are analyzed with low and high resolution microscopes to assess whether any physical or structural damage has occurred. This paper presents results of the examinations of LiF, Li2O, LiNbO3, CaF2, B4C, and LaB6 target materials following rapid thermal and electron beam heating tests.
Fe‐Doped ZnO Nanoparticles: The Oxidation Number and Local Charge on Iron, Studied by <sup>57</sup>Fe Mößbauer Spectroscopy and DFT Calculations (2013)

Iron bru: Fe-doped ZnO may contain Fe(2+) and Fe(3+) species. Whilst Mößbauer spectroscopy can distinguish these sites in pure oxides FeO and Fe(2)O(3), it gives very similar shifts for Fe-doped phases. This result is rationalized by electron redistribution from the dopant site to the crystal matrix. Mößbauer shifts correlate with the local charge on the Fe sites and different dopant sites can be identified by the Mößbauer quadrupole splitting (see figure).