gebhart/patrepeval huggingface dataset:
Fast Single-Turn Sensitive Stator Interturn Fault Detection of Induction Machines Based on Positive- and Negative-Sequence Third Harmonic Components of Line Currents (2010)

Unambiguous detection of stator interturn faults for induction machines at their incipient stage, i.e., few turns' fault, has recently received great attention. Traditionally, interturn faults are detected using negative-sequence current and impedance. However, their effectiveness under supply imbalance conditions is questionable. Recently, line-current third harmonic (± 3f) has also been used in an attempt to achieve this goal. Nevertheless, issues such as inherent structural asymmetry and voltage imbalance also influence the + 3f. In this paper, the positiveand negative-sequence third harmonics (± 3f) of line current under different operating conditions have been explored by combining space and time harmonics. The suggested fault signature was obtained by removing residual components from tested quantities. Simulation and experimental results using 1 s of data indicate that the proposed ± 3f signatures are capable of very effectively detecting even a single-turn fault, and distinguish it from voltage imbalance and structural asymmetry.
A DANTE tagging sequence for the evaluation of translational sample motion (1990)

A magnetic resonance imaging sequence that is sensitive to translational motion such as that seen with cardiac contraction is presented. The sequence employs DANTE radio-frequency excitation with a continuous magnetic field gradient to generate a grid pattern of lines. There is improved line resolution and reduced eddy-current formation over current techniques.
Spectral Diffusion Decay in Spin Resonance Experiments (1962)

In spin resonance experiments random flipping by ${T}_{1}$ or ${T}_{2}$ processes of nearby, nonresonant spins introduces fluctuations into the precessional frequency of the observed spins. These fluctuations may be described by means of a stochastic model, and for wide classes of both Markoffian and non-Markoffian distributions we make predictions for the line shape, for the free induction decay, and for various spin-echo signals. If the homogeneous broadening of the line is due to a dipolar interaction term, then we find that the conditional distribution for the precessional frequency has the shape of a Lorentzian with a cutoff on the wings, rather than a Gaussian shape as commonly assumed. The causes and consequences of Lorentzian diffusion are analyzed in detail for samples in which ${T}_{1}$ processes control the source of local frequency fluctuations and for samples in which ${T}_{2}$ processes dominate. Recent two- and three-pulse spin-echo experiments of Mims et al. dramatically confirm the predictions of Lorentzian diffusion for electron paramagnetic resonances in samples with temperature-dependent diffusion, as well as with temperature-independent diffusion. "Instantaneous" diffusion caused by the action of the applied pulses is predicted by our model and explains features of Mims' data. The generality of our principal results still permits the outcome of various resonance experiments to be predicted, even when a simple dipolar interaction is no longer an adequate model.
HSP90 Interacts with and Regulates the Activity of Heat Shock Factor 1 in <i>Xenopus</i> Oocytes (1998)

Transcriptional activation of heat shock genes is a reversible and multistep process involving conversion of inactive heat shock factor 1 (HSF1) monomers into heat shock element (HSE)-binding homotrimers, hyperphosphorylation, and further modifications that induce full transcriptional competence. HSF1 is controlled by multiple regulatory mechanisms, including suppression by additional cellular factors, physical interactions with HSP70, and integration into different cellular signaling cascades. However, the signaling mechanisms by which cells respond to stress and control the HSF1 activation-deactivation pathway are not known. Here we demonstrate that HSP90, a cellular chaperone known to regulate several signal transduction molecules and transcription factors, functions in the regulation of HSF1. The existence of HSF1-HSP90 heterocomplexes was shown by coimmunoprecipitation of HSP90 with HSF1 from unshocked and heat-shocked nuclear extracts, recognition of HSF1-HSE complexes in vitro by using HSP90 antibodies (Abs), and recognition of HSF1 in vivo by HSP90 Abs microinjected directly into oocyte nuclei. The functional impact of HSP90-HSF1 interactions was analyzed by using two strategies: direct nuclear injection of HSP90 Abs and treatment of cells with geldanamycin (GA), an agent that specifically blocks the chaperoning activity of HSP90. Both HSP90 Abs and GA delayed the disassembly of HSF1 trimers during recovery from heat shock and specifically inhibited heat-induced transcription from a chloramphenicol acetyltransferase reporter construct under control of the hsp70 promoter. HSP90 Abs activated HSE binding in the absence of heat shock, an effect that could be reversed by subsequent injection of purified HSP90. GA did not activate HSE binding under nonshock conditions but increased the quantity of HSE binding induced by heat shock. On the basis of these findings and the known properties of HSP90, we propose a new regulatory model in which HSP90 participates in modulating HSF1 at different points along the activation-deactivation pathway, influencing the interconversion between monomeric and trimeric conformations as well as transcriptional activation. We also put forth the hypothesis that HSP90 links HSF1 to cellular signaling molecules coordinating the stress response.
Staff Development: What are the Qualifications? (1975)

Associate Director, Nursing Staff and Program Development, University of Iowa Hospitals and Clinics
Unsteady Measurements and Computations on an Oscillating Airfoil with Gurney Flaps (2001)

The effect of a Gurney flap on an unsteady airfoil flow is experimentally and computationally examined. In the experiment, the details of the unsteady boundary layer events on the forward portion of the airfoil are measured. In the computation, the features of the global unsteady flow are documented and correlated with the experimental observations.The experiments were conducted in the North Carolina State University subsonic wind tunnel on an oscillating airfoil at pitch rates of 65.45 degrees/sec and 130.9 degrees/sec. The airfoil has a NACA0012 cross-section and is equipped with a 1.5% or 2.5% chord Gurney flap. The airfoil is tested at Reynolds numbers of 96,000, 169,000 and 192,000 for attached and light dynamic stall conditions. An array of surface-mounted hot-film sensors on the forward 25% chord of the airfoil is used to measure the unsteady laminar boundary layer separation, transition-to-turbulence, and turbulent reattachment. In parallel with the experiments incompressible Navier-Stokes computations are conducted for the light dynamic stall conditions on the airfoil with a 2.5%c Gurney flap at a Reynolds number of 169,000.The experimental measurements show that the effect of the Gurney flap is to move the separation, transition and reattachment forward on the airfoil. This effect is more marked during the airfoil's pitch-down than during pitch-up. The computational results verify these observations, and also show that the shedding of the dynamic stall vortex is delayed. Thus the adverse effects of dynamic stall are mitigated by the Gurney flap.
Reentry Time Prediction Using Atmospheric Density Corrections (2008)

Errors in the upper atmosphere density models have a significant influence on the accuracy of orbit prediction and, specifically, on the accuracy of the prediction of the reentry time of space objects. The determination of current time corrections to the atmosphere density and their use in orbit prediction are proposed as a method for increasing the accuracy of reentry time prediction. The potential effect of increasing the accuracy of space object reentry time prediction, associated with accounting for the corrections to the Naval Research Laboratory MSIS-00 atmosphere density model, is estimated for space objects having both spherical and nonspherical shapes. The results show that the reentry time predictions obtained using this approach are significantly improved. The improvement is better for spherical objects than arbitrary shaped objects due to the time varying nature of the ballistic coefficient of arbitrary shaped objects. The use of the atmospheric density corrections provides insight into the time variations of individual space object aerodynamic characteristics and allows their use in predicting the reentry time.
Tumour necrosis factor-α-induced glucose-stimulated insulin secretion inhibition in INS-1 cells is ascribed to a reduction of the glucose-stimulated Ca2+ influx (2008)

The present study was undertaken to determine how tumour necrosis factor-alpha (TNF-alpha) elicits the inhibition of glucose-stimulated insulin secretion (GSIS) in rat insulinoma cells (INS)-1 beta-cells. TNF-alpha pretreatment did not change the expression levels of insulin, PDX-1, glucose transporter 2, glucokinase, K(ATP) channels, Ca(2)(+) channels, and exocytotic molecules and, furthermore, did not reduce the glucose-stimulated ATP level. On the other hand, TNF-alpha reduced the glucose-stimulated influx of Ca(2)(+). The TNF-alpha treatment was thought to activate c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and NF-kappaB inflammatory signals, since TNF-alpha increased phospho-JNK and phospho-p38 and reduced I kappaB levels. Inhibitors of these signaling pathways prevented the TNF-alpha-induced reduction of the Ca(2)(+) influx and GSIS. Overexpression of MEKK3, a possible mediator from the TNF-alpha receptor to the JNK/p38 and NK-kappaB signaling cascade, increased the levels of phospho-JNK, phospho-p38, and NF-kappaB, and reduced the glucose-stimulated Ca(2)(+) influx and GSIS. The reduction of the Ca(2)(+) influx and GSIS in MEKK3-overexpressing INS-1 cells was also prevented by inhibitors of JNK, p38, and NF-kappaB. These data demonstrate that TNF-alpha inhibits GSIS by reducing the glucose-stimulated Ca(2)(+) influx, possibly through the activation of JNK and p38 MAPK and NF-kappaB inflammatory signals. Thus, our findings suggest that the activation of stress and inflammatory signals can contribute to the inhibition of GSIS in the development of diabetes.
Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis (2016)

Doxorubicin (DOX) remains the most effective anticancer agent which is widely used in several adult and pediatric cancers, but its application is limited for its cardiotoxicity and hepatotoxicity. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for many diseases. In this study, we found that intraperitoneal injection of hydrogen-rich saline (H<sub>2</sub> saline) ameliorated the mortality, cardiac dysfunction, and histopathological changes caused by DOX in rats. Meanwhile, serum brain natriuretic peptide (BNP), aspartate transaminase (AST), alanine transaminase (ALT), albumin (ALB), tissue reactive oxygen species (ROS), and malondialdehyde (MDA) levels were also attenuated after H<sub>2</sub> saline treatment. What is more, we further demonstrated that H<sub>2</sub> saline treatment could inhibit cardiac and hepatic inflammation and apoptosis relative proteins expressions by western blotting test. In conclusion, our results revealed a protective effect of H<sub>2</sub> saline on DOX-induced cardiotoxicity and hepatotoxicity in rats by inhibiting inflammation and apoptosis.
Practice of Neutral Earthing for Different Network Conditions (2003)

The medium voltage distribution networks of public supply and industry in Germany are operated with different neutral earthing schemes. Besides the well known methods of isolated neutral, resonant earthing and current limiting earthing also combined methods are used to fulfill the targets of customer supply quality and operational requirements such as reliable fault detection and automation. This paper presents examples of industrial and public networks where neutral earthing schemes were optimized. The planning procedure, the analysis of prerequisites, the evaluation of technical and economical benefits and the implementation including short circuit trials are presented. Finally the experience of several years of operation is summarized showing that the tailoring of neutral earthing methods to the network conditions leads to a minimum of failure related outages.
Location, Location, Location (2012)

Rural hospitals rethink their strategies for recruiting physicians, including offering unique incentives.
Clinical Notes on Feline Respiratory Viral Disease (1966)

Abstract— A description is made of the symptomology and treatment of two associated outbreaks of a feline respiratory infection in a quarantine cattery. The outbreak was controlled with the use of antibiotics together with corticosteroids and vitamins. Résumé— On décrit la symptomatologie et le traitement de l'apparition d'une infection des voies respiratoires chez des félins en quarantaine. L'éclosion fut controlée par l'emploi d'antibiotiques associés aux cortico‐stéroides et aux vitamines. Zusammenfassung— Die Symptome und die Therapie zweier venvandter Epidemien von Infektion der Luftwege, die in einer Quarantänestation für Katzen ausbrachen, werden beschrieben. Die Epidemie konnte durch Antibiotika, im Verein mit Corticosteroiden und Vitaminen, erfolgreich unter Kontrolle gebracht werden.
Perceptual user interfaces: multimodal interfaces that process what comes naturally (2000)

unimodal passive-monitoring PUI can alone.
Visually readable and highly stable self-display photonic humidity sensor (2011)

A visually readable and highly stable self-display photonic humidity sensor has been fabricated through the fast magnetically induced self-assembly of carbon-encapsulated superparamagnetic colloidals, followed by an instant radical polymerization to fix the photonic crystal structures inside a polyacrylamide glycol gel matrix. Because of the use of magnetic assembly and radical-polymerization, we can quickly and conveniently prepare the photonic humidity sensor on a large scale with arbitrary shape which has an important significance in large-scale industrial production. The photonic humidity sensor can self-display brilliant colors from navy blue to light red as the relative humidity changes from 11% to 97%. The whole shift of the reflection wavelength is nearly 160 nm, which almost covers the whole visual region and its intensity is readable by the naked eye. In addition, cycle tests demonstrate that the photonic humidity sensor has a good stability and reproducibility in its diffraction signal. Therefore, coupled with low cost and no power consumption, the photonic humidity sensor system can realize colorimetric detection of humidity, similarly to pH indicator paper.
Verification, validation, and integrity issues in expert and database systems: Two perspectives (2001)

This paper is directed at two central objectives. The first is to identify and to establish areas of overlap between the expert and database system domains. The second is to present a view of existing and ongoing work concerning the verification, validation, and integrity (VV&I) of rule base and database systems. The paper combines reviews from the two perspectives of the expert systems and database systems communities, with the express aim of identifying possibilities where VV&I knowhow of the one may also be of value to the other (and, vice versa), especially with respect to the identified areas of overlap. © 2001 John Wiley & Sons, Inc.
Alkamides from<i>Cissampelos glaberrima</i> (1996)

Two alkamides, deca-2E,4E-dienoic acid isobutylamide (1) and octa-2E,4E-dienoic acid isobutylamide (2), were isolated from the roots of Cissampelos glaberrima (Menispermaceae). Their structures were established by spectral and physical methods. Traces of two new alkamides, decen-2-oic acid isobutylamide (3) and decanoic acid isobutylamide (4), were identified by mass spectrometry.
HONORIS CAUSA DE LA UNIVERSIDAD VERACRUZANA A JOSÉ NEGRETE, DE BIOMÉDICAS (2006)

JOSE NEGRETE MARTINEZ, ADSCRITO A LA UNIDAD PERIFERICA DEL INSTITUTO DE INVESTIGACIONES BIOMEDICAS (IIBM) UBICADA EN EL CAMPUS XALAPA DE LA UNIVERSIDAD VERACRUZANA, RECIBIO DE ESTA INSTITUCION EL DOCTORADO HONORIS CAUSA. DURANTE LA CEREMONIA, REALIZADA EN EL MUSEO DE ANTROPOLOGIA DE XALAPA, JOSE NEGRETE -PRECURSOR DE LA INTELIGENCIA ARTIFICIAL EN MEXICO- LLAMO A INDUCIR, A INCITAR AL LACTANTE, P RVULO, ADOLESCENTE TEMPRANO, AL ESTUDIANTE UNIVERSITARIO LA OSADIA, Y AL COLABORADOR, A ADIESTRARSE, PERCIBIR, RAZONAR Y ABDUCIR, CON EL PROPOSITO DE IMPULSAR LAS CAPACIDADES INTELECTUALES DE LAS NUEVAS GENERACIONES. EL FUNDADOR DEL DEPARTAMENTO DE BIOFISICA Y BIOMATEM TICAS DE ESE INSTITUTO ASEGURO QUE PARA CADA EDAD DEL DESARROLLO HAY UNA CONSTRUCCION OSADA POR HACER. EN CADA ETAPA DEBE EMPLAZARSE A CONTINUAR LA ACTIVIDAD DE EDIFICACION CON OTRA DESTRUCTIVA -ESTIMULADA POR LA AUTOCRITICA-, QUE SIGA A SU VEZ CON UNA PRODUCCION PROVECHOSA. HABLO DE SUS PROFESORES, A QUIENES RECORDO POR LA EMOCION CON QUE TRANSMITEN SUS VALORES, ENTRE ELLOS, PRAXILA SOTERO (LA AUTOCONFIANZA EN LOS JUICIOS), EFREN CARLOS DEL POZO Y ARTURO ROSENBLUETH (LA EMOCION DEL DESCUBRIMIENTO CIENTIFICO POR EXPERIMENTACION). CON SUS ESCRITOS, DIJO, HAN SIDO SUS FORJADORES SANTIAGO RAMON Y CAJAL (POR LA CONFIANZA EN LA CIENCIA HECHA) Y RICHARD DAWKINS (DE QUIEN APRENDIO A EVITAR LA ANESTESIA QUE PRODUCE LA COTIDIANIDAD). ANTE EL CONSEJO UNIVERSITARIO, EL RECTOR DE LA UNIVERSIDAD VERACRUZANA, RAUL ARIAS -ACOMPANADO POR EL GOBERNADOR DEL ESTADO, FIDEL HERRERA, Y EL VICEPRESIDENTE DE LA ACADEMIA MEXICANA DE CIENCIAS Y DIRECTOR DE BIOMEDICAS, JUAN PEDRO LACLETTE-, MANIFESTO QUE ACOGER AL CIENTIFICO JOSE NEGRETE FUE UN ACIERTO, Y SU CONDECORACION, UNA MUESTRA QUE REAFIRMA EL COMPROMISO CON LA LABOR CIENTIFICA Y LOS VALORES DEL HUMANISMO, QUE SON LOS QUE ANIMAN Y CONSAGRAN EL ESPIRITU DE TRANSFORMACION PREDOMINANTE EN EL SENO DE NUESTRA COMUNIDAD. LA DISTINCION A JOSE NEGRETE FUE PROPUESTA POR LA JUNTA ACADEMICA DE LA FACULTAD DE FISICA E INTELIGENCIA ARTIFICIAL Y APROBADA POR UNANIMIDAD POR EL PLENO DEL CONSEJO UNIVERSITARIO DE LA UNIVERSIDAD VERACRUZANA. SE ANOTAN DATOS DE LA TRAYECTORIA ACADEMICA Y PROFESIONAL DEL UNIVERSITARIO DISTINGUIDO.
Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex (1998)

Systemic administration of ISIS 2302, a 20-mer antisense phosphorothioate oligonucleotide targeting human intercellular adhesion molecule-1 mRNA, causes prolongation of plasma clotting times in both monkey and human studies. The anticoagulant effects of ISIS 2302 were investigated with both in vitro coagulation assays in human plasma and purified enzyme systems. At high oligonucleotide plasma concentrations (>100 μg/mL), prolongation of the prothrombin and thrombin times was observed. In a thrombin time assay using purified components, high concentrations of ISIS 2302 inhibited thrombin clotting activity both by stimulating inhibition by heparin cofactor II and directly competing with fibrinogen for binding to anion binding exosite I. In contrast, low concentrations of ISIS 2302 (<100 μg/mL) showed a selective, linear prolongation of the activated partial thromboplastin time (PTT). The rate limiting effect of 50 μg/mL ISIS 2302, which prolonged the PTT to 1.5 times control, was identified by sequential modification of the clotting assay. Delaying addition of oligonucleotide until after contact activation failed to correct prolongation of the PTT. The calcium-dependent steps of the intrinsic pathway were individually assessed by adding sufficient activated coagulation factor to correct the PTT in plasma deficient in that specific factor. Addition of factor XIa, IXa, VIIIa, or Va failed to correct the PTT in the presence of ISIS 2302. In contrast, 0.2 nmol/L factor Xa corrected prolongation of the PTT in factor X–deficient plasma with or without oligonucleotide present. ISIS 2302 (50 μg/mL) did not prolong a modified Russel viper venom time, suggesting no significant inhibition of prothrombinase. Thus, 50 μg/mL ISIS 2302 prolonged the PTT by selectively inhibiting intrinsic tenase activity. ISIS 2302 showed partial inhibition of intrinsic tenase activity (to approximately 35% of control) at clinically relevant oligonucleotide concentrations in a chromogenic assay. This activity was oligonucleotide sequence–independent but required the phosphorothioate backbone, suggesting that inhibition of intrinsic tenase is a general property of this class of oligonucleotides. These results are relevant to both the therapeutic use of phosphorothioate oligonucleotides and the potential design of inhibitors of the intrinsic tenase complex, a novel target for anticoagulation. © 1998 by The American Society of Hematology.
Involvement of cyclin‐dependent kinases in axotomy‐induced retinal ganglion cell death (2002)

We have tested the role of cyclin-dependent kinases (CDKs) in the type 3B death of axotomized retinal ganglion cells, by injecting intraocularly olomoucine, roscovitine, or butyrolactone I. Each of these inhibits CDK1, CDK2, and CDK5; CDK1 and CDK2 are involved in cell proliferation, whereas CDK5 is involved in neuronal differentiation. The inhibitors partially protected ganglion cells against the effects of axotomy. These agents may affect the ganglion cells directly, because CDK1, its regulatory subunit cyclin B1, and CDK5 were identified immunohistochemically in the perikarya of ganglion cells, and this was confirmed for CDK1 and CDK5 in Western blots of the ganglion cell layer. These blots showed an axotomy-induced phosphorylation of CDK5 occurring remarkably quickly (within 6 hours of axotomy) but little if any change in the phosphorylation state of CDK1. In addition, we studied the expression of proliferation markers, including proliferating cell nuclear antigen (PCNA) and the synthesis of DNA, by immunohistochemical and autoradiographic methods. Normal or axotomized ganglion cells did not express PCNA and did not synthesize DNA. Although we cannot exclude the possibility that axotomized ganglion cells may leave their quiescent state, our data show that they did not progress beyond the G1 phase of the cell cycle. Finally, in contrast to inhibitors of CDKs, cell cycle blockers with different targets than CDKs did not protect ganglion cells. Globally, our results suggest that axotomy-induced death of ganglion cells involves the activation of CDK1, CDK2, or CDK5 (most probably CDK5) but not the full cell cycle machinery.
Photochemically Based Synthesis of Deoxy Sugars. Synthesis of 2-Deoxy-<u>D</u>-<u>Arabino</u>-Hexopyranose (2-Deoxy-<u>D</u>-Glucose) and Several of Its Derivatives from 3,4,6-Tri-<u>O</u>-Acetyl-<u>D</u>-Glucal (1982)

Abstract The photolysis of methyl 3,4,6-tri-O-acetyl-2-bromo-2-deoxy-β-D-glucopyranoside (2) in 2-propanol results in replacement of the bromine with a hydrogen to give methyl 3,4,6-tri-O-acetyl-2-deoxy-β-D-arabino-hexopyranoside (4) in 91% yield. Similar reactions take place for methyl 3,4,6-tri-O-acetyl-2-bromo-2-deoxy-α-D-mannopyranoside (3) and a mixture of the a and β anomers of 1,3,4,6-tetra-O-acetyl-2-bromo-2-deoxy-D-glucopyranose (7) and 1,3,4,6-tetra-O-acetyl-2-bromo-2-deoxy-D-mannopyranose (8). Since compounds 2, 3, 7, and 8 each were synthesized from 3,4,6-tri-O-acetyl-D-glucal (1), photochemical reaction appears to be a useful process in 2-deoxy sugar synthesis from glycals.