gebhart/patrepeval huggingface dataset:
<title>Stereo matching with energy-minimizing snake grid for 3D face modeling</title> (2004)

An energy minimizing snake algorithm that runs over a grid is designed and used to reconstruct high resolution 3D human faces from pairs of stereo images. The accuracy of reconstructed 3D data from stereo depends highly on how well stereo correspondences are established during the feature matching step. Establishing stereo correspondences on human faces is often ill posed and hard to achieve because of uniform texture, slow changes in depth, occlusion, and lack of gradient. We designed an energy minimizing algorithm that accurately finds correspondences on face images despite the aforementioned characteristics. The algorithm helps establish stereo correspondences unambiguously by applying a coarse-to-fine energy minimizing snake in grid format and yields a high resolution reconstruction at nearly every point of the image. Initially, the grid is stabilized using matches at a few selected high confidence edge points. The grid then gradually and consistently spreads over the low gradient regions of the image to reveal the accurate depths of object points. The grid applies its internal energy to approximate mismatches in occluded and noisy regions and to maintain smoothness of the reconstructed surfaces. The grid works in such a way that with every increment in reconstruction resolution, less time is required to establish correspondences. The snake used the curvature of the grid and gradient of image regions to automatically select its energy parameters and approximate the unmatched points using matched points from previous iterations, which also accelerates the overall matching process. The algorithm has been applied for the reconstruction of 3D human faces, and experimental results demonstrate the effectiveness and accuracy of the reconstruction.
Assessment of Cross-Reactivity between <i>Mycobacterium bovis</i> and <i>M. kansasii</i> ESAT-6 and CFP-10 at the T-Cell Epitope Level (2007)

Cross-reactivity between Mycobacterium kansasii ESAT-6 and CFP-10 homologues and their M. bovis counterparts can confound the interpretation of immunodiagnostic tests for tuberculosis. M. kansasii is a nontuberculous mycobacterial species cultured from skin test-positive cattle in Great Britain. Using peptides derived from M. bovis and M. kansasii ESAT-6 and CFP-10 regions that differ between these species, we investigated the species specificity and cross-reactivity at the level of individual bovine T-cell epitopes. Our results demonstrated that all peptides tested are fully cross-reactive, with the exception of one ESAT-6-derived peptide that harbored an M. bovis-specific epitope(s) when it was recognized in the context of bovine leukocyte antigen (BoLA)-DQ but that was cross-reactive with its M. kansasii homologues when it was restricted by BoLA-DR. This observation further highlights that prediction of species specificity by comparing sequence identity/homology alone is not sufficient and that individuals with diverse major histocompatibility complex constellations need to be tested to characterize the cross-reactivity or species specificity of peptide-based reagents.
Modelling of hollow cylinder tests on Boom Clay: softening, anisotropy and strain localization (2012)

info:eu-repo/semantics/nonPublished
Risikofaktoren für Krebs und MS in Kuhmilch und Rindfleisch? (2016)

Abstract Die globale epidemiologische Analyse des Auftretens von Brust‐ und Dickdarmkrebs gibt Anlass zu der Vermutung, dass der Konsum von Fleisch‐ und Milchprodukten unserer Milchrinder zum Risiko dieser Erkrankungen beiträgt. Von unserer Gruppe wurde eine Reihe neuer Einzelstrang‐DNAs aus Serum und Milch von europäischen Milchkühen isoliert. Es handelt sich um zirkuläre Moleküle (∼1000 bis 3000 Basen) vermutlich viraler Herkunft, deren Erbgut offensichtlich nicht in die Chromosomen der Tiere eingebaut wird, sondern nicht integriert (episomal) vorliegt. Nach Übertragung in menschliche Zellen ist diese DNA genetisch aktiv. In zwei Läsionen von Patienten mit Multipler Sklerose konnten verwandte Isolate nachgewiesen werden. Konzepte für eine mögliche ätiologische Rolle dieser Agenzien bei Erkrankungen des Menschen wurden entwickelt. Die Rolle solcher Sequenzen bei Krebs und neurologischen Erkrankungen wird zurzeit intensiv untersucht.
Rapid diagnosis and tumor margin assessment during pancreatic cancer surgery with the MasSpec Pen technology (2021)

Intraoperative delineation of tumor margins is critical for effective pancreatic cancer surgery. Yet, intraoperative frozen section analysis of tumor margins is a time-consuming and often challenging procedure that can yield confounding results due to histologic heterogeneity and tissue-processing artifacts. We have previously described the development of the MasSpec Pen technology as a handheld mass spectrometry-based device for nondestructive tissue analysis. Here, we evaluated the usefulness of the MasSpec Pen for intraoperative diagnosis of pancreatic ductal adenocarcinoma based on alterations in the metabolite and lipid profiles in in vivo and ex vivo tissues. We used the MasSpec Pen to analyze 157 banked human tissues, including pancreatic ductal adenocarcinoma, pancreatic, and bile duct tissues. Classification models generated from the molecular data yielded an overall agreement with pathology of 91.5%, sensitivity of 95.5%, and specificity of 89.7% for discriminating normal pancreas from cancer. We built a second classifier to distinguish bile duct from pancreatic cancer, achieving an overall accuracy of 95%, sensitivity of 92%, and specificity of 100%. We then translated the MasSpec Pen to the operative room and predicted on in vivo and ex vivo data acquired during 18 pancreatic surgeries, achieving 93.8% overall agreement with final postoperative pathology reports. Notably, when integrating banked tissue data with intraoperative data, an improved agreement of 100% was achieved. The result obtained demonstrate that the MasSpec Pen provides high predictive performance for tissue diagnosis and compatibility for intraoperative use, suggesting that the technology may be useful to guide surgical decision-making during pancreatic cancer surgeries.
Vertigem como Manifestação Inaugural de Mieloma Múltiplo (2018)

O mieloma múltiplo é uma neoplasia maligna de células B, caracterizada pela proliferação descontrolada e clonal de plasmócitos. O envolvimento intracraniano é incomum. A vertigem e o desequilíbrio são manifestações extremamente raras e habitualmente tardias de mieloma múltiplo com extensão intracraniana. Este trabalho tem como objetivo a apresentação de um raro caso de um doente com 55 anos com queixas de vertigem como manifestação inaugural de mieloma múltiplo da fossa posterior em estádio avançado, enfatizando os aspetos clínicos, diagnósticos e terapêuticas efetuadas. Recebido: 06/09/2017 - Aceite: 30/10/2017
Characterization of Membrane Lipidome Changes in Pseudomonas aeruginosa during Biofilm Growth on Glass Wool (2014)

Bacteria cells within biofilms are physiologically distinct from their planktonic counterparts. In particular they are more resistant to detrimental environmental conditions. In this study, we monitored the evolution of the phospholipid composition of the inner and outer membranes of P. aeruginosa during the biofilm formation (i.e., from 1-, 2-, to 6-day-old biofilm). Lipidome analyses were performed by electrospray ionization mass spectrometry. In addition to the lipidomic analysis, the fatty acid composition was analysed by gas chromatography/mass spectrometry. We found that the lipidome alterations of the inner and the outer membranes varied with the biofilm age. These alterations in phospholipid compositions reflect a higher diversity in sessile organisms than in planktonic counterparts. The diversity is characterized by the presence of PE 30∶1, PE 31∶0 and PG 31∶0 for the lower masses as well as PE 38∶1, 38∶2, 39∶1, 39∶2 and PG 38∶0, 38∶1, 38∶2, 39∶1, 39∶2 for the higher masses. However, this lipidomic feature tends to disappear with the biofilm age, in particular the high mass phospholipids tend to disappear. The amount of branched chains phospholipids mainly located in the outer membrane decreased with the biofilm age, whereas the proportion of cyclopropylated phospholipids increased in both membranes. In bacteria present in oldest biofilms, i.e., 6-day-old, the phospholipid distribution moved closer to that of planktonic bacteria.
Conserved role of dopamine in the modulation of behavior (2012)

Dopamine is an ancient signaling molecule. It is responsible for maintaining the adaptability of behavioral outputs and is found across taxa. The following is a summary of the role of dopamine and the mechanisms of its function and dysfunction. We discuss our recent findings on dopaminergic control of behaviors in C. elegans and discuss its potential implications for work in the fields of C. elegans and Parkinson research.
Direct Photoaffinity Labeling by Dolastatin 10 of the Amino-terminal Peptide of β-Tubulin Containing Cysteine 12 (2004)

Tubulin with bound [5-3H]dolastatin 10 was exposed to ultraviolet light, and 8-10% of the bound drug cross-linked to the protein, most of it specifically. The primary cross-link was to the peptide spanning amino acid residues 2-31 of beta-tubulin, but the specific amino acid could not be identified. Indirect studies indicated that cross-link formation occurred between cysteine 12 and the thiazole moiety of dolastatin 10. An equipotent analog of dolastatin 10, lacking the thiazole ring, did not form an ultraviolet light-induced cross-link to beta-tubulin. Preillumination of tubulin with ultraviolet light, known to induce cross-link formation between cysteine 12 and exchangeable site nucleotide, inhibited the binding of [5-3H]dolastatin 10 and cross-link formation more potently than it inhibited the binding of colchicine or vinblastine to tubulin. Conversely, binding of dolastatin 10 to tubulin inhibited formation of the cross-link between cysteine 12 and the exchangeable site nucleotide. Dithiothreitol inhibited formation of the beta-tubulin/dolastatin 10 cross-link but not the beta-tubulin/exchangeable site nucleotide cross-link. Modeling studies revealed a highly favored binding site for dolastatin 10 at the + end of beta-tubulin in proximity to the exchangeable site GDP. Computational docking of an energy-minimized dolastatin 10 conformation at this site placed the thiazole ring of dolastatin 10 8-9 A from the sulfur atom of cysteine 12. Dolastatin 15 and cryptophycin 1 could also be docked into positions that overlapped more extensively with the docked dolastatin 10 than with each other. This result was consistent with the observed binding properties of these peptides.
Cell-Mediated Immunity in Ruminants (1994)

The Leukocytes: Markers, Tissue Distribution, and Functional Characterization, C.J. Howard and W.I. Morrison. Ontogeny of T Cells, W.R. Hein. The Major Histocompatibility Complex, L. Andersson and C.J. Davies. The T Cell Receptor, N. Ishiguro and W.R. Hein. The Cytokines: Origin, Structure, and Function, D.M. Haig, C.J. McInnes, P.R. Wood, and H.F. Seow. Induction of T Cell-Mediated Immune Responses in Ruminants, D.J. McKeever. Lymphocyte Recirculation and Homing, W.G. Kimpton, E.A. Washington, and R.N. Cahill. Neutrophils and Killer Cells, J.A. Roth. East Coast Fever (Theileria parva): Cell-Mediated Immunity and Protection, B.M.L. Goddeeris, W.I. Morrison, E.L. Taracha, and D.J. McKeever. Infectious Bovine Rhinotracheitis (Bovine Herpesvirus 1): Helper T Cells, Cytotoxic T Cells, and NK Cells, M. Denis, G. Splitter, E. Thiry, P.-P. Pastoret, and L.A. Babiuk. Foot and Mouth Disease (Aphthovirus): Viral T Cell Epitopes, T. Collen. Maedi-Visni (Lentivirus): Cell-Mediated Immune Responses in Pathogenesis, B.A. Blacklaws, P. Bird, and I. McConnell. Cell-Mediated Responses against Gastrointestinal Nematode Parasites of Ruminants, S.J. McClure and D.L. Emery. Cytokine Application in Infectious Diseases, M. Campos, D.L. Godson, H.P.A. Hughes, and L.A. Babiuk. Index.
ChemInform Abstract: CHARACTERIZATION OF THE PRODUCTS OF ALKYLATION OF 2′‐DEOXYADENOSINE AND 2′‐DEOXYGUANOSINE BY CHLOROETHYL ETHYL SULFIDE (1979)

Abstract 2′‐Desoxy‐adenosin und 2′‐Desoxy‐guanosin werden mit Chlorethyl‐ethyl‐sulfid umgesetzt und die erhaltenen Reaktionsprodukte untersucht.
Peak and integrated reflectivity, wavelength and gamma optimization of Mo/Si, and Mo/Be multilayer, multielement optics for extreme ultraviolet lithography (1999)

Reported is the optimization of the fabrication of Mo/Si multilayer systems produced by e-beam evaporation and ion-beam smoothening. The impact of a number of coating parameters is verified such as variation of the mirror’s center wavelength and the metal fraction of the bilayer (Γ ratio), resulting in reflectivities up to 68.6% at normal incidence. Parallel to this experimental work, a numerical optimization based on experimentally determined multilayer properties is carried out on the throughput of multimirror lithographic systems for the 11–15 nm wavelength region using Mo/Si and Mo/Be coatings. The center wavelength, Γ ratio and layer stack have been optimized. The calculations show an optimum throughput for a 10-mirror Mo/Si system at 14.4 nm, assuming a light source with a wavelength independent spectrum.
Black Lipid Membranes:  Visualizing the Structure, Dynamics, and Substrate Dependence of Membranes (2004)

The structure and long-time dynamics of suspended lipid bilayers made of 1-stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (SOPE) in the gel phase was interrogated using electrical measurements co-recorded with second harmonic generation (SHG) micrographs. SHG microscopy was shown to be an efficient method for distinguishing between the regions of bilayer and annulus as well as probing structural and dynamical variations within a single bilayer. Micromachined silicon chips and two types of plastic partitions, delrin and polyethylene, were investigated as substrate materials. Silicon chips yielded the most stable bilayers, lasting for 1 or 2 days. The membrane characteristics, including the amount of incorporated solvent within the bilayer, the dynamics of bilayer formation, and the stability of the bilayer, were found to be strongly substrate-dependent. In a second set of experiments, SHG-active membrane dyes, di-8-ANEPPS and di-4-ANEPPS, were used to interrogate the domain structure of the same suspended bilayers using scanning two-photon fluorescence (2PF) and SHG microscopy, again correlated with capacitance measurements. Using these dyes, an enhancement in the SHG signal due to membrane potential was recorded, and the rates of molecular diffusion for di-4-ANEPPS through the membrane were investigated. Polarization-resolved SHG imaging was used to determine the orientation of the dye molecules within the membrane.
Synthesis of 2-arylpropionaldehydes through hydroformylation (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-arylpropionaldehydes through hydroformylationDenis Neibecker, Regis Reau, and Serge LecolierCite this: J. Org. Chem. 1989, 54, 22, 5208–5210Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/jo00283a008https://doi.org/10.1021/jo00283a008research-articleACS PublicationsRequest reuse permissionsArticle Views384Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
2-Arylureidobenzoic Acids:  Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5 (2003)

A series of 2-arylureidobenzoic acids (AUBAs) was prepared by a short and effective synthesis, and the pharmacological activity at glutamate receptors was evaluated in vitro and in vivo. The compounds showed noncompetitive antagonistic activity at the kainate receptor subtype GluR5. The most potent compounds showed more than 50-fold selectivity for GluR5 compared to GluR6 and the AMPA receptor subtypes GluR1-4. The structure-activity relationships for the AUBAs showed distinct structural requirements for the substituents on the two aromatic ring systems. Only para-substituents were tolerated on the benzoic acid moiety (ring A), whereas ring B tolerated a variety of substituents, but with a preference for lipophilic substituents. The most potent compounds had a 4-chloro substituent on ring A and 3-chlorobenzene (6b), 2-naphthalene (8h), or 2-indole (8k) as ring B and had IC(50) values of 1.3, 1.2, and 1.2 microM, respectively, in a functional GluR5 assay. Compound 6c (IC(50) = 4.8 microM at GluR5) showed activity in the in vivo ATPA rigidity test, indicating that 6c has better pharmacokinetic properties than 8h, which was inactive in this test. The AUBAs are the first example of a series of noncompetitive GluR5-selective antagonists and may prove to be important pharmacological tools and leads in the search for therapeutic glutamatergic agents.
EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-β signaling in lung fibroblasts (2006)

These findings suggest that EM703 improves bleomycin-induced pulmonary fibrosis in mice by actions of anti-inflammation and regulation of TGF-beta signaling in lung fibroblasts.
Should I Repeat My 1:2s QC Rejection? (2012)

The repeat-sampling strategies provide an effective tactic to take advantage of the desirable properties of both the 1:2s and 1:3s QC rules. Additionally, the power of the repeat-sampling strategies compares favorably with the power of 2 common QC multirules. These improvements come with a modest increase in the average number of controls tested.
Structural Damage Monitoring for Civil Structures (1997)

The authors would like to express their gratitude to the National Science Foundation for their support through Grant CMS - 9526102.
Magnetic Resonance, General Medical (2000)

Abstract Nuclear magnetic resonance (NMR) is the basic physical phenomenon in which certain nuclei absorb and emit radiofrequency (RF) radiation while in the presence of a magnetic field. The noninvasive nature of NMR techniques, including magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), has allowed explosive developments in biomedical applications since the late 1970s. MRI of protons is now a widely accepted clinical imaging technique, whereas MRS of various nuclei, including 31 P, 1 H, 13 C, 23 Na, and 19 F, can provide a vast amount of metabolic and physiological information. MRI provides significant advantages over many other imaging techniques in terms of resolution, contrast, and its noninvasive nature. Although not as common in clinical medicine, MRS also provides valuable metabolic information that cannot be obtained by other techniques. This article reviews the fundamentals of spatial encoding, contrast, artifacts, and applications of MRI as well as some recent advances in the field. Some applications of biomedical MRS of various nuclei are also discussed.
A New Method for the Evaluation of the ‘Antioxidant Power’ of Wines (1998)

Phenols present in wines are responsible for its antioxidant properties. Traditionally the antioxidant power of wines has been measured using in vitro tests principally based on the inhibition of human LDL oxidation and also using the ORAC assay with different reactive species. This work describes a new method to evaluate the antioxidant power of several red and white wines based on a FIA system with electrochemical detection. It represents a significant improvement over other previously reported methods since it is based on the chemical structure of polyphenols and does not require the use of reactive species.
Tau Epitopes are Incorporated into a Range of Lesions in Alzheimerʼs Disease (1987)

The neuronal microtubule-associated phosphoprotein, tau, has been identified as a major antigenic component of paired helical filaments in Alzheimer's disease (AD). The extent and distribution of altered tau antigens in AD brain, other than those found in neurofibrillary tangles (NFT) and senile plaque (SP) neurites, has not been widely discussed. We have examined tau immunoreactivity in AD using the monoclonal antibody (MAb), 5E2, raised against human fetal tau. Four types of abnormalities were recognized by MAb 5E2, each having some counterpart in Bielschowsky silver impregnations: 1) NFT; 2) thickened neurites in SP; 3) diffuse perikaryal staining seen in some neurons apparently lacking NFT; and 4) a dispersed network of randomly oriented thickened neurites not clustered into discrete plaques but found in NFT- and SP-rich cerebral cortex. These four alterations could also be recognized using three different polyclonal antibodies which had strong tau immunoreactivity but were optimally shown by MAb 5E2. Our findings demonstrate the complexity of altered tau-immunoreactive neuronal elements and emphasize the widespread abnormality of microtubule-associated proteins in AD cortex.
Dynamic gratings in optical fibers: Synthesis and sensing applications (2010)

We proposed two schemes of generating and localizing dynamic gratings in optical fibers: one is based on the gain saturation in erbium-doped fiber; the other is based on Brillouin scattering in the fiber. By using these dynamic gratings, fully distributed strain/temperature sensors have been demonstrated. In this presentation, we review the principles, basic schemes, and experimental demonstrations of the novel dynamic grating techniques.
Attitude determination, control and stabilization of UoSAT-2 (1987)

Gravity-gradient torques are very weak and are, alone, unable to provide a satisfactory degree of pointing precision and, if undamped, exhibit considerable libration. Thus, passive gravity-gradient torques are augmented on UoSAT-2 by the use of magnetic torques generated through the use of ‘magnetorquer’ coils, which are commutated with the local geomagnetic field vector according to control algorithms implemented by an onboard computer.The attitude dynamics, stabilization procedures, attitude determination procedures and orbital results of UoSAT-2 are described, indicating the expected limits of performance and plans for future work.