gebhart/patrepeval huggingface dataset:
HUMAN TUMOR CELL UROKINASE-TYPE PLASMINOGEN ACTIVATOR (uPA): DEGRADATION OF THE PROENZYME FORM (pro-uPA) BY GRANULOCYTE (1991)

SUMMARY When human granulocytes were stimulated with the chemotactic peptide FNLPNTL (N-formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosi­ nyl-lysin; in the presence of cytochalasin B), proteolytic enzymes were released which prevented activation of tumor-cell derived pro-uPA by plasmin. Elastase was identified by use of eglin C (elastase inhibitor) and an inhibitory monoclonal antibody to elastase as the functional prote­ olytic enzyme in these granulocyte supernatants. Purified human granulocyte elastase cleaves pro-uPA at amino acid position lIe 159-lIe 160 thus generating an enzymatically inactive two-chain form of uPA, as judged by N-terminal amino acid sequence analysis. An additional minor elastase-mediated cieavage site was detected at posi­ tion Thrl65-Thr l66. This form of uPA was indistinguishable by SDS-PAGE from plasmin-generated enzymatically active HMW-uPA. Action of plasmin on the proenzyme form of uPA (pro-uPA) generates an enzymatically active uPA-molecule (high molecular weight form; HMW-uPA) which is cleaved at amino acid position Lys l58-lIe l59 (Mr=33,000 (B-chain) and 22,000 (A­ chain). Thus elastase cannot substitute for plasmin in the proteolytic activation of pro-uPA to enzymatically active HMW-uPA. Enzymatically active HMW-uPA, however, was not affected by elastase. Elastase­ containing granulocytes were identified by immunohistochemical staining of elastase in breast cancer tissue. Granulocytes were located close to the tumor cells and also in the tumor stroma surrounding the tumor nests. These tumor cells contain pro-uPA. Evidently, the conversion of tumor cell pro-uPA into enzymatically active HMW-uPA is controled by elastase released from granulocytes into the tumor tissue.
A novel approach to enhance the bandwidth of miniaturized dielectric resonator antennas (2004)

The paper presents the concept and implementation of a wideband, high-gain miniaturized dielectric resonator antenna (DRA). A dual-resonance characteristic is achieved by merging the resonances of an aperture antenna and a DRA; miniaturization is provided by the high dielectric constant of the resonator. The design enhances the bandwidth of the constituent antennas without compromising their efficiency and radiation characteristics. In addition, the design enforces low cross-polarization levels as well its a unique polarization direction over the entire bandwidth. It is shown that, with proper design, the two resonances inherent in all DRA designs with resonant feed structures can be merged for bandwidth optimization. In addition, the similarity of the aperture and DRA radiation characteristics allows preservation of the radiation patterns and polarization over the entire bandwidth. The design parameters are summarized and simulation results given. A 0.2/spl lambda//sub 0/ antenna exhibiting over 25% bandwidth and gain exceeding 4 dBi has been built and characterized.
Antigenic Specificity of γA Polymers (1970)

Abstract Studies of the polymer and monomer γA isolated from a single patient with γA multiple myeloma indicate that the polymer has an antigenic specificity distinct from the monomer. This specificity is dependent upon the polymer configuration and is unrelated to individual antigenic specificity.
Interfacial bonding in W/C and W/B4C multilayers (1989)

The nature of carbon bonding in W/C and W/B4C multilayer structures is investigated by Auger electron spectroscopy (AES). The interfacial roughness in these x-ray mirrors directly affects their use as efficient optical elements. A significant contribution to interfacial roughness is the possible presence of second phases, WC in particular for the W/C and W/B4C combinations. AES depth profiling of the multilayer interfaces is used as a direct method to probe for the existence of WC.
Synthesis of a new anticonvulsant labelled with 14C: 1, 4-dihydro-1-[4′-(ethylaminoacetyl)-aminophenyl]-3 (2H)-isoquinolinone (1978)

1, 4-Dihydro-1-[4′-(ethylaminoacetyl)-aminophenyl]-3 (2H)-isoquinolinone was labelled with 14C in two different positions: in one case in position 3 of the isoquinoline ring, in the other case in the carbonyl group of the ethylaminoacetyl moiety.
Immuno- and hemocompatibility of amino acid pairing peptides for potential use in anticancer drug delivery (2014)

Amino acid pairing peptide-based nanoparticles were recently introduced as promising carriers for hydrophobic anticancer drugs. The AC8 peptide, n-FEFQFNFK-c, is based on the amino acid pairing (AAP) design with 8 amino acids and hence the designated name AAP8. The nanoparticles (NPs) AAP8 have modified either on the C-terminal or on both terminal, by conjugation with diethylene glycol (DEG) . Here, the in vitro biocompatibilities of the NPs and their modified versions were compared and the potential of these NPs as carriers for the hydrophobic anticancer drug pirarubicin was determined as well as the peptide-drug co-assembly complexes. The toxicity of the NPs, DEGylated NPs, and blended mixtures with pirarubicin, was tested against the human adenocarcinoma lung cancer cell line, A549. The amino-end DEGylated NP, (NP-I), had superior biocompatibility over the non-modified NPs or double DEGylated NPs (NP-II). NP-I had very low hemolytic activity (1%) while NP and NP-II had marginal (8%) and acceptable (5%) hemolytic activity, respectively. All three types of NPs did not activate the complement system via the classical and alternative pathways nor did they activate the anaphylotoxin C3a. However, NP-II and its drug complex effectively activate the complement terminal attack complex. The lectin pathway was not activated by NP-I and NP-II, but was to a small extent by the non-modified NPs, with no lectin activation when complexed with drug. These results indicate NP-I is the most promising peptide for use as a drug delivery system, highlighting the importance of proper modification in peptides for drug delivery systems.
Partialsynthese neuer Ergolinderivate aus Clavinalkaloiden, 2. Mitt.<sup>1)</sup> O‐Acyl‐8‐hydroxymethyl‐6‐methylergol‐8‐ene und ‐ergol‐9‐ene (1983)

Abstract Die Titelverbindungen sind durch Acylierung von Elymoclavin (1) bzw. Lysergol (2) mit Säurechloriden, im Fall der Ester von 2 auch durch Isomerisierung von O‐Acyl‐ 1 mit aktiviertem Al 2 O 3 darstellbar. Umgekehrt führt die Acylierung von 2 in bestimmten Fällen spontan zur Bildung eines Gemisches der O‐Acylderivate von 1 und 2. .
Influences of buffer material and fabrication atmosphere on the electrical properties of CdTe solar cells (2019)

Abstract The electrical properties such as interface energy barriers, defect energy levels, and densities dictate the performance of thin film solar cells. Here, we show that these properties can be quantified in cadmium telluride (CdTe) thin‐film solar cells using admittance spectroscopy‐based techniques. Our results reveal that the electrical properties in CdTe thin‐film solar cells depend on both buffer material and the fabrication atmosphere. We find that only a negligible front contact barrier exists at the CdS/CdTe front junction regardless of the fabrication atmospheres, while an obvious front barriers are observed at the ZnMgO (ZMO)/CdTe junctions. Both CdS/CdTe and ZMO/CdTe solar cells exhibit back contact barrier. The energy level of defects is shallower in CdS/CdTe cells than in ZMO/CdTe cells. The fabrication atmosphere influences the electrical properties, i.e., an oxygen‐free atmosphere reduces the front and back barrier heights and lowers the energy level of defects. The results provide critical insights for understanding and optimizing the performance of CdTe thin‐film solar cells.
Dechanneling from 2-MeV<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant="normal">He</mml:mi></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>Damage in Gold (1973)

The dechanneling of 2-MeV ${\mathrm{He}}^{+}$ incident in the [001] direction of monocrystalline gold films has been investigated by means of the backscattering technique. The aligned spectra of the undamaged crystal indicate good agreement with channeling theories regarding the surface dechanneling and the dechanneling as a function of depth. Damage was introduced by 2-MeV ${\mathrm{He}}^{+}$ incident in a random direction and the resultant increase of the dechanneling rate was studied as a function of damage dose. It is found that the dechanneling is mainly due to defect clusters produced in energetic displacement cascades. A dechanneling cross section of ${\ensuremath{\sigma}}_{d}=2.3\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}14}$ ${\mathrm{cm}}^{2}$ is derived under the assumption that all of the dechanneling is due to the clusters visible by transmission electron microscopy (TEM). The dechanneling cross section is about a factor of 5 smaller than the geometrical cross section of the clusters as determined by TEM. Deviations from linearity in the dechanneling-rate-versus-dose curve are noticeable at 5 \ifmmode\times\else\texttimes\fi{} ${10}^{15}$ ${\mathrm{He}}^{+}$/${\mathrm{cm}}^{2}$. An analysis of the saturation behavior gave a value of ${r}_{0}=89$ \AA{} for the average radius of a displacement cascade.
Soil Salinity Changes in the Jordan Valley Potentially Threaten Sustainable Irrigated Agriculture (2013)

灌溉和农业惯例在上的综合效果，超过中的 60% 个在约旦山谷(JV ) 玷污咸度乔丹是农业的生产被种，在 20092010 期间在这研究被调查。由于在农业操作，收割模式，灌溉管理，和天气条件的差别， 206 件表层土和心土样品从代表性的农场被花每 1 ～ 3 km 一纵贯(N-S ) 有 1 ～ 2 km 的横断侧面的程度。土壤浸透的摘录(ECse ) 的电的电导率， Ca， Mg， K， Na， Cl，和 Na 吸附比率(SAR ) 在浸透的浆糊摘录被决定。结果显示在 JV 的大约 63% 土壤是确实盐的，从哪个几乎 46% 是中等到强烈盐。沿着 JV 的 N-S 横断， ECse 在表层土样品从 4.5 ～ 14.1 dS m1 增加了。类似的增加为心土样品被观察。土壤咸度的主要化学部件；即， Ca， Mg，和 Cl，也沿着山谷的 N-S 横断显示出类似的增加。而且与以前的地采样相比，结果证明那在土壤变化，在 JV 的咸度是戏剧的。另外，强加了一在 JV 在 60% 土壤存在和对敏感庄稼的潜在的威胁，被发现那 Cl，在 Cl 集中比 710 mg L1 大的地方。在流行干旱地中海条件下面，改进灌溉水和增加的水和化肥使用效率的管理应该是不可缺少的在 JV 保存并且支撑已经易碎的农业土壤。
A Study on Micelle Formation in Colloidal Electrolyte Solutions (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Study on Micelle Formation in Colloidal Electrolyte SolutionsC. Botre, V. L. Crescenzi, and A. MeleCite this: J. Phys. Chem. 1959, 63, 5, 650–653Publication Date (Print):May 1, 1959Publication History Published online1 May 2002Published inissue 1 May 1959https://doi.org/10.1021/j150575a004RIGHTS & PERMISSIONSArticle Views218Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (468 KB) Get e-Alerts
Context-Aware Handover Based On Active Network Technology (2003)

Context-aware computing can play a major role to improve the services of mobile networking systems. In this paper, we focus on optimizing handover decisions based not only on the signal quality, but also on the knowledge about the context of mobile devices and networks. Since context information and context processing evolves fast, we propose a flexible, integrated approach for context management, which can adapt in several ways. Our architecture encompasses active platforms in network nodes and mobile devices, distributed context management components on these platforms, and service deployment for network services. This flexible architecture is able to actively deploy different handover services. It can manage different kinds of context information and allow mobile devices to be always connected to the most suitable access network. Our architecture is validated in a prototype implementation.
Efeito do paraquat e glyphosate sobre espécimes de poaceae e convolvulaceae em condições de déficit hídrico (2017)

O uso de herbicidas é uma prática muito utilizada para o controle de plantas daninhas. Entretanto, sua eficácia pode ser comprometida pela menor disponibilidade de água no ambiente, influenciando na absorção, translocação e metabolismo destes pelas plantas. O presente trabalho objetivou estudar o efeito dos herbicidas paraquat (Gramoxone) e glyphosate (Roundup Original) para o controle de capim-braquiária [Urochloa decumbens (Stapf) R.D.Webster (Poaceae)] e corda-de-viola [Merremia cissoides (Lam.) Hallier f. (Convolvulaceae)], em condições de déficit hídrico. O experimento foi conduzido em casa de vegetação, em delineamento experimental inteiramente casualizado e esquema fatorial 5×3, com três repetições. Foram consideradas cinco épocas de indução de déficit hídrico (0, 1, 3, 5 e 7 dias) e três caldas de pulverização [paraquat, glyphosate e testemunha (com a aplicação de água, apenas)]. As avaliações de porcentagem de controle foram realizadas aos 2, 5, 7, 10, 14 e 21 dias após a aplicação dos tratamentos. Aos 21 dias foi determinado o teor de massa seca das plantas daninhas. Pelos resultados obtidos, observou-se que a partir de 5 dias com déficit hídrico, a eficácia dos herbicidas paraquat e glyphosate para o controle de capim-braquiária e corda-de-viola foi reduzida.
Active antenna Receivers with Calibration Circuit for Digital Beamforming at 8.45GHz (2002)

Active antenna receiver for digital beamforming (DBF) array antenna at 8.45GHz for next generation wireless telecommunication is presented. This proposed system implement calibration circuit for restraint of phase and amplitude unbalance among array branches. We also describe active patch antenna with amplifier and near zero IF mixer for receiving DBF. We also examine this proposed receiver's ability to function as a digital beam former. In this result, the digital beam forming can be realized that side lobe level is below -3 dB and the half power beam width is about 70°, in case of scanning range is limited ±30° by using two proposed receivers. The ability of this receiver is almost same that of common receivers using isotopic antenna. It is sufficient for this high-speed wireless communication application.
ShatterPlots: Fast Tools for Mining Large Graphs (2009)

Graphs appear in several settings, like social networks, recommendation systems, computer communication networks, gene/protein biological networks, among others. A deep, recurring question is “What do real graphs look like?” That is, how can we separate real ones from synthetic or real graphs with masked portions? The main contribution of this paper is ShatterPlots, a simple and powerful algorithm to extract patterns from real graphs that help us spot fake/masked graphs. The idea is to shatter a graph, by deleting edges, force it to reach a critical (“Shattering”) point, and study the properties at that point. One of the most striking patterns is the “30-per-cent“: at the Shattering point, all real and synthetic graphs have about 30% more nodes than edges. One of our most discriminative patterns is the “NodeShatteringRatio“, which can almost perfectly separate the real graphs from the synthetic ones of our extensive collection. Additional contributions of this paper are (a) the careful, scalable design of the algorithm, which requires only O(E) time, (b) extensive experiments in a large collection of graphs (19 in total), with up to hundreds of thousands of nodes and million edges, and (c) a wealth of observations and patterns, which show how to distinguish synthetic or masked graphs from real ones.
The effect of film thickness on the incidence of the defect bridging of intagliations on film coated tablets (1980)

Journal Article The effect of film thickness on the incidence of the defect bridging of intagliations on film coated tablets Get access R C Rowe, R C Rowe I.C.I. Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, SK10 2TG, UK Correspondence: I.C.I. Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, SK10 2TG, U.K. Search for other works by this author on: Oxford Academic Google Scholar S F Forse S F Forse I.C.I. Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, SK10 2TG, UK Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 32, Issue 1, September 1980, Pages 647–648, https://doi.org/10.1111/j.2042-7158.1980.tb13022.x Published: 12 April 2011 Article history Received: 18 April 1980 Published: 12 April 2011
ChemInform Abstract: STRUCTURES AND CHROMOTROPIC PROPERTIES OF 1,4‐BIS(4,5‐DIPHENYLIMIDAZOL‐2‐YL)BENZENE DERIVATIVES (1979)

Abstract Bei der Oxidation mit Eisen(III)‐cyanid erhält man aus dem 1,4‐Bis‐imidazolyl‐benzol (I) die Folgeprodukte (IV), (V) sowie Dimere wie (VI), während mit Bleidioxid die Oxidationsprodukte (II) ′ä (III) gebildet Werden.
GM-CSF Plus Antigenic Peptide Vaccination in Locally Advanced Melanoma Patients (2007)

Twenty-four (24) pretreated patients with relapsed high-risk resected The American Joint Committee on Cancer (AJCC) stage IIA-IV melanoma received adjuvant peptide vaccinations derived from the melanosomal antigens MelanA/MART1, MAGE-1, gp100, and tyrosinase, according to patient tumor-associated human leukocyte antigen (HLA) restricted antigen expression, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF). Pretreatment was comprised of surgery (n=23 primary tumor; n=23 metastases), local radiotherapy (n=2), immunotherapy (n=23), chemotherapy (n=10), and chemoimmunotherapy (n=1), respectively. All patients received peptide vaccines in an adjuvant setting. Seven (7) patients were relapse free for 3+ up to 25+ months. Of the patients exhibiting progressive disease (n=17), 13 patients developed metastases during vaccination (9 local, 4 distant), and 4 patients developed metastases (2 local, 2 distant) after finishing vaccine therapy. Two (2)-year local and distant metastases-free survival, 2-year distant metastases-free survival, and 2-year overall survival were calculated as 8.6%, 68%, and 85%, respectively. Vaccine treatment was well tolerated, with no severe side-effects. Twenty (20) of 24 patients developed local delayed-type hypersensitivity (DTH) reactions to synthetic peptide vaccination. Transient fever (n=2) and pain in muscle/bone (n=2) occurred rarely. In conclusion, antigenic peptide vaccination, combined with GM-CSF, is safe and may yield clinical benefits in relapsed high-risk resected melanoma patients.
Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects (2014)

Macrophage markers in skeletal muscle of obese subjects are elevated and inversely relate to insulin sensitivity. The present study aimed to investigate whether short-term high-fat high-calorie (HFHC) diet already increases macrophage markers and affects glucose metabolism in skeletal muscle of healthy lean subjects. Muscle biopsies were obtained from 24 healthy lean young men before and after a 5-day HFHC-diet. mRNA expression levels of relevant genes in muscle and glucose, insulin, C-peptide and cholesteryl ester transfer protein (CETP) levels in plasma were measured. In addition, we assessed hepatic triacylglycerol ('triglyceride') (HTG) content by magnetic resonance spectroscopy and subcutaneous white adipose tissue (sWAT) biopsies were analysed histologically from a subset of subjects (n=8). A 5-day HFHC-diet markedly increased skeletal muscle mRNA expression of the general macrophage markers CD68 (3.7-fold, P<0.01) and CD14 (3.2-fold, P<0.01), as well as the M1 macrophage markers MARCO (11.2-fold, P<0.05), CD11c (1.8-fold, P<0.05) and MRC1 (1.7-fold, P<0.05). This was accompanied by down-regulation of SLC2A4 and GYS1 mRNA expression, and elevated plasma glucose (+4%, P<0.001) and insulin (+55%, P<0.001) levels together with homoeostasis model assessment of insulin resistance (HOMA-IR) (+48%, P<0.001), suggesting development of insulin resistance (IR). Furthermore, the HFHC-diet markedly increased HTG (+118%, P<0.001) and plasma CETP levels (+21%, P<0.001), a marker of liver macrophage content, whereas sWAT macrophage content remained unchanged. In conclusion, short-term HFHC-diet increases expression of macrophage markers in skeletal muscle of healthy men accompanied by reduced markers of insulin signalling and development of IR. Therefore, recruitment of macrophages into muscle may be an early event in development of IR in response to short-term HFHC-feeding.
Squeezing frequency combs (2006)

We have developed the full theory of a synchronously pumped type I optical parametric oscillator (SPOPO). We derive expressions for the oscillation threshold and the characteristics of the generated mode-locked signal beam. We calculate the output quantum fluctuations of the device, and find that, in the degenerate case (coincident signal and idler set of frequencies), perfect squeezing is obtained when one approaches threshold from below for a well defined "super-mode', or frequency comb, consisting of a coherent linear superposition of signal modes of different frequencies which are resonant in the cavity.
Reaction of anthracene with He+ and Ar+ at room temperature (1994)

This paper deals with the measurement of the rate coefficient of anthracene (C14H10) with atomic ions such as He+ and Ar+. The experiment was carried out at room temperature in a flowing afterglow Langmuir probe apparatus equipped with movable mass spectrometer. We obtained a rate coefficient of 6.4×10−9 cm3s−1 and 1.8×10−9 cm3 s−1 and 1.8×10−9 cm3 s−1 for He+ and Ar+ respectively.
Performance Comparison of Diversity Combining ARQ Error Control Schemes with Multi-Packet Detection Schemes (2010)

Lost packets, either due to errors or collisions, are usually discarded and need to be retransmitted, leading to performance losses. In this paper we compare the performance of two different approaches to cope with lost packets. One alternative is a multi-packet detection approach able to separate up to Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> mobile terminals transmitting in one slot. The other alternative is a low-complexity soft combining ARQ scheme (Automatic Repeat reQuest) employed in a TDMA (Time Division Multiple Access) architecture. This paper evaluates the uplink non-saturated packet delay and goodput for a Poisson traffic generator. Our analytical results are validated by simulation using joint PHY (physical layer) and MAC (Medium Access Control) behavior.
Antibody functionalization for pretargeted imaging and radiotherapy Nanotechnology for targeted personalized medicines and theranostics (2018)

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