gebhart/patrepeval huggingface dataset:
Confined ultrafast torsional dynamics of Thioflavin-T in a nanocavity (2011)

The influence of confinement in the supramolecular β-cyclodextrin nanocavity on the excited state torsional dynamics of the amyloid fibril sensor, Thioflavin-T, is explored using subpicosecond fluorescence up-conversion spectroscopy. In the presence of β-cyclodextrin, the emission intensity and the fluorescence lifetime of Thioflavin-T significantly increases, indicating the confinement effect of the nanocage on the photophysical behaviour of the dye. Detailed time-resolved fluorescence studies show an appreciable dynamic Stokes' shift for the dye in the β-cyclodextrin nanocavity. Analysis of the time-resolved area normalized emission spectra (TRANES) indicates the formation of an emissive TICT state. The rate of formation of the TICT state, as calculated from the time dependent changes in the peak frequency and the width of the emission spectra, is found to be substantially slower in the β-cyclodextrin nanocavity compared to that in bulk water. Present results indicate that ultrafast torsional motion in Thioflavin-T is significantly retarded due to confinement by the β-cyclodextrin nanocavity.
N-(1-Pyrene)maleimide: a fluorescent crosslinking reagent (1976)

<P>Abstract copyright UK Data Service and data collection copyright owner.</P>The <i>Labour Force Survey Annual Eurostat Datasets</i> form the UK component of the <i>European Union Labour Force Survey</i> (EU LFS), and consist of a subset of core variables from the UK Quarterly Labour Force Survey (held at the UK Data Archive under GN 33246), alongside primary and secondary derived variables computed by Eurostat from the core variables supplied. The data comprise seasonal or calendar quarters, depending on the date, and are not directly comparable with the UK QLFS quarters. Although all datasets in this series are called 'annual', from 1999-2008 they only include data for quarter two of the survey year, as the questions were only asked in this quarter. From 2009, the questions were asked all year. Quarterly EU LFS datasets from 1999 onwards are also available (see under GN 33366) and 'ad hoc' modules (run each year to supplement the information from the core EU LFS questionnaire) are available from 2002 onwards (see under GN 33400). <br> <br> Users should note that the LFS Eurostat datasets available from the UK Data Archive comprise UK data only, and no data from other EU countries are included here. Further information about the EU LFS can be found on the Eurostat <a href="http://ec.europa.eu/eurostat/statistics-explained/index.php/EU_labour_force_survey" title="EU Labour Force Survey">EU Labour Force Survey</a> webpage.<br> <br> The UK Labour Force Survey (LFS) is a unique source of articulated information using international definitions of employment and unemployment and economic inactivity, together with a wide range of related topics such as occupation, training, hours of work and personal characteristics of household members aged 16 years and over. The first LFS was conducted in 1973 and continues to be one of the reasons for carrying out the survey. Eurostat co-ordinates information from labour force surveys in the European Union (EU) member states in order to assist the EU in such matters as the allocation of the Social Fund. Between 1984 and 1991 the survey was carried out annually, and moved to a quarterly cycle (the QLFS) from May 1992. Further information may be found in the main LFS documentation (see link below).<br> <br> <b>LFS Documentation (main LFS)</b><br> Besides the EU LFS documentation (see below), documentation is also available to accompany the main UK LFS datasets available from the Archive. This largely consists of the latest version of each document alongside the appropriate questionnaire for the year concerned. However, LFS documentation volumes are updated periodically by ONS, so users are advised to check the ONS <a href="http://www.ons.gov.uk/ons/guide-method/method-quality/specific/labour-market/labour-market-statistics/index.html" title="LFS User Guidance">LFS User Guidance</a> pages before commencing analysis.<br> <br>
Hybrid Seismic Modeling Based on Discrete-wave Number and Finite-difference Methods (1996)

Any calculation of seismic wave propagation comprising the seismic source, the travel path, and the receiver site in a single finite-difference (FD) model requires a considerable amount of computer time and memory. Moreover, the methods currently available for including point sources in the 2D FD calculations are far-field approximations only. Therefore we have developed a new hybrid method for treating the seismic wave fields at localized 2D near-surface structures embedded in a 1D background medium, and excited by a point source. The source radiation and propagation in the background model is solved by the discrete-wave number (DW) method, while the propagation in the local 2D structure is calculated by the FD method. The coupling between the two sets of calculations is performed on a rectangular excitation box surrounding the local structure. We show the usefulness of the method in ground-motion studies where both near-field source effects and local site effects are important. Technical problems connected with the inconsistency between the 3D source radiation and the 2D FD calculation are minor for the relatively distant in-plane point explosive sources, but are more serious for the in-plane dislocation sources.
Enclosed Space Detection System (ESDS) (1996)

The Enclosed Space Detection System (ESDS) is a device to detect the presence of persons hiding in the enclosed spaces of a vehicle. The system operates by detecting the presence of the human ballistocardiogram (a small but measurable shock wave which propagates through the body each time the heart beats, and which results in small but theoretically detectable deflections of the surface of the enclosure)
Opportunistic lookahead routing procedure for delay tolerant networks (2012)

Delay Tolerant Networks are wireless networks that have sporadic network connectivity, thus rendering the existence of instantaneous end-to-end paths from a source to a destination difficult or impossible. Hence, in such networks, message delivery relies heavily on the store-and-forward paradigm to route messages. However, limited knowledge of the contact times between the nodes poses a big challenge to effective forwarding of messages. In this thesis, we discuss several aspects of routing in DTNs and present one algorithm and three variants for addressing the routing problem in DTNs: (i) the Look-ahead Protocol, in which the forwarding decision at each node to its immediate or one-hop neighbor is based on the position of the packet / message in the queue of the neighboring node(ii) Backpressure based lookahead, where a lookahead factor is introduced with the basic backpressure equation. This factor takes into account the difference of queue lengths from the neighbors, (iii) a two-step lookahead protocol, where the forwarding decision is sometimes based on the instantaneous one-hop neighbors of the neighboring node. We also present simulation results of these protocols and compare these results to the existing standard routing protocols for DTNs. In all the algorithms, we look to optimize the amount of network bandwidth used by looking one step ahead before making a forwarding decision. By considering the queue in the neighboring nodes, the amount of network resources consumed decreases. The protocols that we propose may come with a slightly higher hop-count per packet than most protocols, but we have tried to maintain a comparable delivery ratio with the existing standard protocols
Induction of heat shock proteins in Chinese hamster ovary cells and development of thermotolerance by intermediate concentrations of puromycin (1987)

During 4 hr after puromycin (PUR: 20 micrograms/ml) treatment, the synthesis of three major heat shock protein families (HSPs: Mr = 110,000, 87,000, and 70,000) was enhanced 1.5-fold relative to that of untreated cells, as studied by one-dimensional gel electrophoresis. The increase of unique HSPs, if studied with two-dimensional gels, would probably be much greater. In parallel, thermotolerance was observed at 10(-3) isosurvival as a thermotolerance ratio (TTR) of either 2 or greater than 5 after heating at either 45.5 degrees C or 43 degrees C, respectively. However, thermotolerance was induced by only intermediate concentrations (3-30 micrograms/ml) of puromycin that inhibited protein synthesis by 15-80%; a high concentration of PUR (100 micrograms/ml) that inhibited protein synthesis by 95% did not induce either HSPs or thermotolerance. Also, thermotolerance was never induced by any concentration (0.01-10 micrograms/ml) of cycloheximide that inhibited protein synthesis by 5-94%. Furthermore, after PUR (20 micrograms/ml) treatment, the addition of cycloheximide (CHM: 10 micrograms/ml), at a concentration that reduces protein synthesis by 94%, inhibited both thermotolerance and synthesis of HSP families. Thus, thermotolerance induced by intermediate concentrations of PUR correlated with an increase in newly synthesized HSP families. This thermotolerance phenomenon was compared with another phenomenon termed heat resistance and observed when cells were heated at 43 degrees C in the presence of CHM or PUR immediately after a 2-hr pretreatment with CHM or PUR. Heat protection increased with inhibition of synthesis of both total protein and HSP families. Moreover, this heat protection decayed rapidly as the interval between pretreatment and heating increased to 1-2 hr, and did not have any obvious relationship to the synthesis of HSP families. Therefore, there are two distinctly different pathways for developing thermal resistance. The first is thermotolerance after intermediate concentrations of PUR treatment, and it requires incubation after treatment and apparently the synthesis of HSP families. The second is resistance to heat after CHM or PUR treatment immediately before and during heating at 43 degrees C, and it apparently does not require synthesis of HSP families. This second pathway not requiring the synthesis of HSP families also was observed by the increase in thermotolerance at 45.5 degrees C caused by heating at 43 degrees C after cells were incubated for 2-4 hr following pretreatment with an intermediate concentration of PUR.
High-Tech Materials Could Render Objects Invisible (2006)

No, this isn't the 1 April issue of Science, and yes, you read the headline correctly. Materials already being developed could funnel light and electromagnetic radiation around any object and render it invisible, theoretical physicists predict online in Science this week (www.sciencemag.org/cgi/content/abstract/1125907 and www.sciencemag.org/cgi/content/abstract/1126493). In the near future, such cloaking devices might shield sensitive equipment from disruptive radio waves or electric and magnetic fields. Cloaks that hide objects from prying eyes might not be much further off, researchers say.
Why don't high‐resolution simulations and images match? (1998)

Computer simulations have been used for many years to understand experimental high‐resolution electron microscope images in a qualitative fashion, but the trend nowadays has been to attempt more quantitative image matching. This has led to the discovery that the contrast in experimental images is much less than in simulated images, typically by a factor of about three. There are many possible causes for this discrepancy, ranging from the mechanisms of scattering of electrons by the specimen through the calculations of the diffracted beam intensities and their focusing by the objective lens to the point spread function of the recording device. No single cause can explain all of the experimental contrast loss, although a combination of many factors could.
A Blockchain-Based Notarization Service for Biomedical Knowledge Retrieval (2018)

Biomedical research and clinical decision depend increasingly on scientific evidence realized by a number of authoritative databases, mostly public and continually enriched via peer scientific contributions. Given the dynamic nature of biomedical evidence data and their usage in the sensitive domain of biomedical science, it is important to ensure retrieved data integrity and non-repudiation. In this work, we present a blockchain-based notarization service that uses smart digital contracts to seal a biomedical database query and the respective results. The goal is to ensure that retrieved data cannot be modified after retrieval and that the database cannot validly deny that the particular data has been provided as a result of a specific query. Biomedical evidence data versioning is also supported. The feasibility of the proposed notarization approach is demonstrated using a real blockchain infrastructure and is tested on two different biomedical evidence databases: a publicly available medical risk factor reference repository and on the PubMed database of biomedical literature references and abstracts.
Efficiency of various insects in germplasm regeneration of carrot, onion and turnip rape accessions (1997)

Abstract Seed regeneration is one of the most important tasks in genebank work. To regenerate germplasm of allogamous, entomophilous plant species in isolation facilities, insects are often used as pollen vectors. The objective of this study was to determine the effect of pollinator species, pollinator densities, pollinator combinations, and flower preferences on the seed quantity and quality of Daucus carota, Allium cepa , and Brassica rapa. The isozyme phosphoglucoisomerase (PGI) served as genetic marker in determining outcrossing rates and pollen dispersal distances. Field plots and isolation cages without insects were used as controls. The pollinators studied consisted of the following insect species from German native fauna: red mason bees ( Osmia rufa L.), hoverflies ( Eristalis tenax L.), and blowflies ( Calliphora sp. and Lucilia sp.). In D. carota and B. rapa , higher seed yields were achieved in isolation cages than in field plots, but in A. cepa lower seed yields were obtained in the isolation cages. Although O. rufa showed no liking for A. cepa , unintentional pollination was effected by this insect in isolation cages. Lower insect densities were necessary for O. rufa than for the various fly species.
The endometrial effects of SERMs (2000)

The ideal selective oestrogen receptor modulator (SERM) would retain an oestrogen-like effect on the bones, the heart and cardiovascular apparatus, and the central nervous system, while acting as an anti-oestrogen on the breast and the genital tract. It seems, however, that such a compound is not available for clinical use yet. The uterine tissue, and particularly the endometrium, defines an area of special interest in the SERM action, since endometrial hyperplasia and cancer has been linked to agonistic oestrogen effects. Additionally, tamoxifen, the SERM which accumulates most of the clinical experience, has been associated with stimulatory effects on endometrium, including the development of cancer. In contrast, the more recent benzothiophenes, led by raloxifene, seem to operate as endometrial antagonists, thus providing an interesting alternative for clinical use. This review analyses the endometrial action of tamoxifen, including the information gathered from laboratory models, the observed endometrial effects in women using tamoxifen, and the epidemiological and molecular data which link the use of tamoxifen with endometrial cancer. A parallel examination of the raloxifene data presents the available experimental and clinical information, suggesting the endometrial neutrality of this compound.
Qualitative Methods in Israel (2008)

This paper surveys the evolution and cur­rent state of the art of qualitative methods as an academic discipline in Israel. By means of a survey carried out especially for this issue of FQS, the paper documents the prevalence of qualitative courses in Israel's institutions of higher learning and other networks which promote qualitative re­search. In addition, the article presents the findings of a separate survey carried out for this issue of all articles published in the past decade in Israel's foremost behavioural science journal "Megamot". It documents the methods used by Israeli scholars, as well as their new and emerging areas of inter­est. The article demonstrates that in recent years there has been a steady increase in interest in qualitative research in Israel. Finally, the paper discusses whether national experience shapes the selection of social scientific methods, and comes to the conclusion that it influences the research area studied but does not necessarily affect the methods used. URN: urn:nbn:de:0114-fqs0503462
Anti-Aging Activity and Non-Toxic Dose of Phytooxyresveratrol from Artocarpus lakoocha Roxb (2012)

Purpose: To determine the anti-aging activity and toxicity doses of phytooxyresveratrol extracted from Artocarpus lakoocha Roxb. Methods: Artocarpus lakoocha 100 g was extracted with 2 ml of 95 % ethanol to obtain phytooxyresveratrol (POV). Total phenolic content, as well as free radical scavenging and anti-glycation activities of POV were characterized in order to assess its anti-aging properties. The models of DNA nicking and bacterial reverse mutation (Ames) were applied to the extract in order to determine its effective and toxic doses, respectively.Results: Phytooxyresveratrol (POV) exhibited antiaging activity. It also showed high levels of phenolic content, radical scavenging activity and anti-glycation. A POV concentration of 25 μg/ml promoted strong anti-DNA nicking. Furthermore, it was non-toxic at concentrations ranging from 5 - 100 μg/ml.Conclusion: In vitro, phytooxyresveratrol (POV) extracted from Artocarpus lakoocha exerted effective anti-aging activity at a concentration of 25 μg/ml. Thus, the substance should be further studied for possible formulation into pharmaceutical products.Keywords: Aging, i, Free radicals, Glycation, Phytooxyresveratrol, DNA nicking.
Bills and Notes: Promissory Notes: Negotiability at Common Law (1932)

Defendant contractors left a check for materialmen in the hands of a third party who appropriated the check to his own use and then, in lieu thereof, gave his own note to the materialmen who endorsed it to a bank and credited the contractors with the amount of the note. In an action by the materialmen against the contractors for services rendered and materials furnished, held, such acceptance and negotiation constituted a payment of the materialmen's claims. Riedman v. Macht, (Ind. App. 1932) 182 N. E. 87.
Clinical Consequences of Posttraumatic Bone Bruise in the Knee (2007)

There is no statistically significant relationship, nor a clinically relevant relationship, between the presence of bone bruise and pain severity in patients with sustained knee injury in general practice.
Low carbon network planning (2010)

This paper investigates the deployment of single frequency terrestrial DVB networks in terms of their carbon footprint. A network optimization tool is presented that is based on evolution optimisation method, the genetic algorithm. The target of the investigation is to design the network considering the minimization of its carbon emissions. For the purpose of the investigation a real mountainous area is examined. The field computations are based on accurate multiple slope uniform theory of diffraction (UTD) approximations. Simulation results show a great reduction of CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> emissions when carbon footprint is included in the optimization process.
Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus (1989)

A herpes simplex virus type 1 variant [C239(TK-)] harboring a deletion in the thymidine kinase (TK) gene was assessed for capacity to establish latent infections. Outbred Swiss Webster mice were inoculated on both hind footpads, and numbers of neurons expressing latency-associated transcript and amounts of viral DNA in latently infected lumbosacral spinal ganglia were scored. C239(TK-) established levels of latent infection that were only slightly lower than those found for either a TK rescued variant of this agent or the parent wild-type KOS. However, in contrast to the TK+ viruses, C239(TK-) could not be reactivated when spinal ganglia were cultured in vitro. The results presented show that expression of the viral TK gene plays no major role in establishment of the latent state but that it functions during reactivation of latent virus from explanted ganglia maintained in vitro.
Teaching and Researching Comparative Subnational Constitutional Law (2011)

I had the opportunity to teach "Comparative Subnational Constitutional Law" as a five-week seminar in Graz, Austria in May-June of 2009.I admit that I have not yet sought to develop, or even apply, any of the theories being debated in comparative constitutional law circles.Professor Vicki Jackson has suggested four goals of comparative constitutional study: 1) developing a better intellectual understanding of other systems; 2) enhancing the capacity for selfreflection on one's own system; 3) developing a normative understanding of best practices; and 4) responding to domestic questions that are comparative in nature.'All of these seem to apply equally to
Myosin-X is a molecular motor that functions in filopodia formation (2006)

Despite recent progress in understanding lamellipodia extension, the molecular mechanisms regulating filopodia formation remain largely unknown. Myo10 is a MyTH4-FERM myosin that localizes to the tips of filopodia and is hypothesized to function in filopodia formation. To determine whether endogenous Myo10 is required for filopodia formation, we have used scanning EM to assay the numerous filopodia normally present on the dorsal surfaces of HeLa cells. We show here that siRNA-mediated knockdown of Myo10 in HeLa cells leads to a dramatic loss of dorsal filopodia. Overexpressing the coiled coil region from Myo10 as a dominant- negative also leads to a loss of dorsal filopodia, thus providing independent evidence that Myo10 functions in filopodia formation. We also show that expressing Myo10 in COS-7 cells, a cell line that normally lacks dorsal filopodia, leads to a massive induction of dorsal filopodia. Because the dorsal filopodia induced by Myo10 are not attached to the substrate, Myo10 can promote filopodia by a mechanism that is independent of substrate attachment. Consistent with this observation, a Myo10 construct that lacks the FERM domain, the region that binds to integrin, retains the ability to induce dorsal filopodia. Deletion of the MyTH4-FERM region, however, completely abolishes Myo10's filopodia-promoting activity, as does deletion of the motor domain. Additional experiments on the mechanism of Myo10 action indicate that it acts downstream of Cdc42 and can promote filopodia in the absence of VASP proteins. Together, these data demonstrate that Myo10 is a molecular motor that functions in filopodia formation.