gebhart/patrepeval huggingface dataset:
Clinical AIDS update (1988)

In summary, although progress against AIDS is being made, tremendous hurdles still exist. More effective prevention methods such as widely disseminated education programs and an effective vaccine are essential. Effective treatment methods are critical. Coordinated ambulatory care AIDS programs are needed to reduce costs and enhance the quality of life of AIDS patients.
Role of matrix elements in the theoretical determination of generalized susceptibilities in metals (1976)

The role of matrix elements in the calculation of the generalized susceptibilities $\ensuremath{\chi}(\stackrel{\ensuremath{\rightarrow}}{\mathrm{q}})$ of metals is discussed using the results of an augmented-plane-wave energy-band calculation for the eigenvalues and eigenfunctions of Sc metal. The inclusion of the oscillator strength matrix elements is found to significantly alter the structure obtained for $\ensuremath{\chi}(\stackrel{\ensuremath{\rightarrow}}{\mathrm{q}})$ in the constant-matrix-element approximation. The effect of local-field corrections on the phonon anomaly in Sc and the observed magnetic ordering of dilute rare-earth Sc alloys are described; in the latter case, a crude estimate of this effect is found to restore a (broad) peak in $\ensuremath{\chi}(\stackrel{\ensuremath{\rightarrow}}{\mathrm{q}})$ at $\stackrel{\ensuremath{\rightarrow}}{\mathrm{q}}\ensuremath{\approx}[0,0,0.5(\frac{\ensuremath{\pi}}{c})]$, in good agreement with experiment.
Thermal Decomposition of Cholesteryl Oleyl Carbonate (1970)

Abstract Cholesteryl oleyl carbonagte decomposes spontaneously, above its melting point, to liberate CO2 independently of the atmosphere. In the presence of O2 CO is evolved in appreciable quantities due to oxidative attack which probably occurs at the olefinic bonds.
Development of a Novel Dynamic Simulink Model of the GT-MHR Core (2007)

A dynamic model of the Gas Turbine-Modular Helium Reactor core has been developed using the Simulink simulation program. The Simulink model utilizes a space-independent neutronics (point-kinetics) model along with a space-dependent heat transfer model of the core to simulate the short time reactor transients. The core model employs unique capabilities of the Simulink program to implement a user-friendly fully interactive environment to perform a variety of reactor transient scenarios.
E-Drama: Facilitating Online Role-play using an AI Actor and Emotionally Expressive Characters (2009)

This paper describes a multi-user role-playing environment, referred to as "e-drama", which enables groups of people to converse online, in scenario driven virtual environments. The starting point of this research, is an existing application known as"edrama", a 2D graphical environment in which users are represented by static cartoon figures. Tools have been developed to enable integration of the existing edrama application with several new components to support avatars with emotionally expressive behaviours, rendered in a 3D environment. The functionality includes the extraction of affect from open-ended improvisational text. The results of the affective analysis are then used to: (a) control an automated improvisational AI actor – EMMA(emotion, metaphor and affect) that operates a bit-part character in the improvisation; (b) drive the animations of avatars using the Demeanour framework in the user interface so that they react bodily in ways that are consistent with the affect that they are expressing. Finally, we describe user trials that demonstrate that the changes made improve the quality of social interaction and users' sense of presence. Moreover, our system has the potential to evolve normal classroom education for young people with or without learning disabilities by providing 24/7 efficient personalised social skill, language and career training via role-play and offering automatic monitoring.
Abstract 4406: Role of KRAS in modulating the metabolomic profile and the response of NSCLC cells to PI3K/mTOR and AMPK interfering agents (2014)

Abstract Background: Non-small-cell lung cancers (NSCLC) constitute the majority of lung cancer cases, whose risk is associated with environmental factors, such as air pollution, and smoking habits. KRAS mutations are present in about 20% of NSCLC patients, mostly at codon 12 and have been associated to tumor progression and resistance to chemotherapy in many types of cancer. Increasingly evidences seem to highlight that the definition of KRAS status is not sufficient to determine its predictive and/or prognostic role in NSCLC, and indicate that different KRAS mutations could differently impact on crucial cellular processes. An issue still to be addressed is whether different KRAS mutations may modulate cellular metabolism with possible implications on different response to anticancer treatments which specifically inhibit metabolism modulating pathways, such as the PI3K/AKT/mTOR axis. Methods: We generated from the human NSCLC cell line NCI-H1299 clones overexpressing WT KRAS, and the three most common NSCLC KRAS mutations (G12C, G12V and G12D). The clones were used to determine in vitro response to PI3K, mTOR and AMPK interfering agents. We applied an explorative mass spectrometry-based untargeted metabolomics strategy to characterize the largest possible number of metabolites that might distinguish the different KRAS mutated clones. Results: KRAS overexpressing clones resulted sensitive to the PI3K inhibitors BKM-120 and PIK-75 and to the PI3K/mTOR dual inhibitor BEZ-235. Metformin (acting on AMPK) did not display a cytotoxic activity on the clones at concentrations below or equal to 1mM. Metabolomics analyses revealed that clones harboring different KRAS mutations at codon 12 had different metabolic remodellings such as different redox buffering system and different glutamine-dependency. Conclusion: The preliminary findings reported herein indicate that specific KRAS mutations at codon 12 are associated to different metabolomics profiles that might have an impact to the response to anticancer treatments. Combination studies including metformin and PI3K/mTOR interfering agents and more detailed metabolomics analyses are ongoing in order to clarify whether metabolic adaptations dependent on KRAS mutants might account for the behaviour of KRAS overexpressing clones treated with different drugs. Citation Format: Elisa Caiola, Laura Brunelli, Mirko Marabese, Marina Chiara Garassino, Gabriella Farina, Massimo Broggini, Roberta Pastorelli. Role of KRAS in modulating the metabolomic profile and the response of NSCLC cells to PI3K/mTOR and AMPK interfering agents. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4406. doi:10.1158/1538-7445.AM2014-4406
Hydraulic Transient Prevention with Dipping Tube Hydropneumatic Tank (2013)

The dipping tube hydropneumatic tank is one of the most efficient equipments to prevent water hammer in water distribution and long distance transmission pipe systems. Due to its low costs and easy to maintain features, dipping tube hydropneumatic tank has many irreplaceable advantages, however it is difficult to determine the correct size and gas volume for real world engineering applications. This paper presents a robust method to solve the problems from theory and application. Based on the Method of Characteristics (MOC) equations, this paper derives the equations for modeling dipping tube hydropneumatic tanks in water distribution systems to prevent water hammer. The equations include MOC, differential orifice head loss equation, gas law, air mass, air velocity and etc. The IBMs scientific subroutine package (SSP) is applied to solve the equations by deriving to the form of X=f (X). The method has been integrated into HAMMER. This paper also presents an example to illustrate the methods of determining the tank size, and the comparison results with sealed hydropneumatic tank and surge tank equipment.
Monoclonal antibodies from NZW x BXSB F1 mice to β2 glycoprotein I and cardiolipin. Species specificity and charge-dependent binding (1996)

NZW x BXSB F1 mice develop a systemic autoimmune syndrome with various lupus-like manifestations. Male animals develop a degenerative coronary disease with myocardial infarction, resulting in death before 6 mo of age. The presence in these mice of anti-phospholipid Abs reacting with beta2-glycoprotein I may contribute to the pathogenesis of the cardiovascular lesions. beta2-glycoprotein I, a plasma protein implicated in various aspects of the coagulation pathway, is also the target of autoantibodies in humans with the anti-phospholipid syndrome. We obtained several mAbs from NZW x BXSB F1 mice that were selected for binding to cardiolipin. Two mAbs are specific for beta2-glycoprotein I and display a species-dependent pattern with preferential reactivity to mouse beta2-glycoprotein I. The other mAbs display charge-mediated interactions with anionic phospholipids in the absence of beta2-glycoprotein I. The analysis of the V region sequences of the mAbs suggests that cationic residues in the H chain complementarity-determining region 3 are important for their phospholipid reactivity. The structural features of the V(H)-D-J(H) junctions of these mAbs further support the view that an increased frequency of unusual V(D)J rearrangements directly contributes to the development of murine autoimmunity.
[Exact description of non-glomerular and glomerular erythrocyte forms in pediatric hematuria]. (1988)

We examined 70 urinary sediments of 35 children with non-glomerular hematuria (NGH) and 65 urinary sediments of 17 children with glomerular hematuria (GH) by phase-contrast microscopy at 1,000 X magnification. In each urinary sediment 200 erythrocytes were classified into 18 types of "non-glomerular erythrocytes" and 15 types of "glomerular erythrocytes". According to the percentage of greatly altered erythrocytes the urinary finding was termed isomorphic, mixed or dysmorphic. In 91% of the urinary sediments of patients with NGH the erythrocyte pattern was isomorphic, and in 91% of the urinary sediments of children with GH it was dysmorphic. 9 types of non-glomerular erythrocytes and 10 types of glomerular erythrocytes constituted 94.5% of all 26,809 erythrocytes examined. Torocytes (doughnut-like cells) can be considered characteristic for GH. This study demonstrates a high specificity of this method in discriminating NGH from GH. The exact morphological description of urinary erythrocytes allows the method to be reproducible. For future use examiners can concentrate on the 19 commonest erythrocyte types.
Topical treatment of cutaneous lesions of acquired immunodeficiency syndrome-related Kaposi sarcoma using alitretinoin gel: results of phase 1 and 2 trials. (2000)

Alitretinoin gel has significant antitumor activity as a topical treatment for AIDS-related KS lesions, substantially reduces the incidence of disease progression in treated lesions, and is generally well tolerated.
Factors Affecting Grain Refinement in Equal-Channel Angular Pressing (2000)

Equal-channel angular (ECA) pressing is a processing procedure capable of refining grain sizes below 1 μm in metallic materials. This study investigates the effects of pressing temperature and sample size on the development of a fine-grained structure. The temperature rise and the applied load during ECA pressing are carefully measured. This study suggests the possibility of scaling-up the ECA-pressing process.
Glycosylation of bioactive C <sub>13</sub> -apocarotenols in <i>Nicotiana benthamiana</i> and <i>Mentha × piperita</i> (2020)

Summary C 13 -apocarotenoids (norisoprenoids) are carotenoid-derived oxidation products, which perform important physiological functions in plants. Although their biosynthetic pathways have been extensively studied, their metabolism including glycosylation remains elusive. Candidate uridine-diphosphate glycosyltransferase genes ( UGTs ) were selected for their high transcript abundance in comparison with other UGTs in vegetative tissues of Nicotiana benthamiana and Mentha × piperita , as these tissues are rich sources of apocarotenoid glucosides. Hydroxylated C 13 -apocarotenol substrates were produced by P450-catalyzed biotransformation and microbial/plant enzyme systems were established for the synthesis of glycosides. Natural substrates were identified by physiological aglycone libraries prepared from isolated plant glycosides. In total, we identified six UGTs that catalyze the unprecedented glucosylation of C 13 -apocarotenols, where glucose is bound either to the cyclohexene ring or butane side chain. MpUGT86C10 is a superior novel enzyme that catalyzes the glucosylation of allelopathic 3-hydroxy- α -damascone, 3-oxo- α -ionol, 3-oxo-7,8-dihydro- α -ionol (Blumenol C) and 3-hydroxy-7,8-dihydro- β -ionol, while a germination test demonstrated the higher phytotoxic potential of a norisoprenoid glucoside in comparison to its aglycone. Glycosylation of C 13 -apocarotenoids has several functions in plants, including increased allelopathic activity of the aglycone, facilitating exudation by roots and allowing symbiosis with arbuscular mycorrhizal fungi. The results enable in-depth analyses of the roles of glycosylated norisoprenoid allelochemicals, the physiological functions of apocarotenoids during arbuscular mycorrhizal colonization and the associated maintenance of carotenoid homeostasis. One-sentence summary We identified six transferases in Nicotiana benthamiana and Mentha x piperita , two rich sources of glycosylated apocarotenoids that catalyze the unprecedented glycosylation of a range of hydroxylated α- and β-ionone/ionol derivatives and were able to modify bioactivity by glucosylation.
Sesquiterpene Quinones from a Marine Sponge Hippospongia sp. that Inhibit Maturation of Starfish Oocytes and Induce Cell Cycle Arrest with HepG2 Cells (2006)

Bioassay-guided isolation of the marine sponge Hippospongia sp. collected at Palau led to the isolation of three sesquiterpene quinone metabolites. They were determined as ilimaquinone (1), 5-epi.-ilimaquinone (2), and 5-epi.-isospongiaquinone (3) by NMR data analysis. Compounds 2 and 3 were obtained as a mixture (ca. 4:1). The cytotoxicity on human tumor cell lines of NCI-H460, HepG2, SF-268, MCF-7, HeLa, and HL-60, inhibitory effects on starfish oocytes maturation, and cell cycle arrest on HepG2 cell line for all compounds were evaluated.
p50α/p55α Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity (2003)

Class Ia phosphoinositide (PI) 3-kinases are heterodimers composed of a regulatory and a catalytic subunit and are essential for the metabolic actions of insulin. In addition to p85alpha and p85beta, insulin-sensitive tissues such as fat, muscle, and liver express the splice variants of the pik3r1 gene, p50alpha and p55alpha. To define the role of these variants, we have created mice with a deletion of p50alpha and p55alpha by using homologous recombination. These mice are viable, grow normally, and maintain normal blood glucose levels but have lower fasting insulin levels. Results of an insulin tolerance test indicate that p50alpha/p55alpha knockout mice have enhanced insulin sensitivity in vivo, and there is an increase in insulin-stimulated glucose transport in isolated extensor digitorum longus muscle tissues and adipocytes. In muscle, loss of p50alpha/p55alpha results in reduced levels of insulin-stimulated insulin receptor substrate 1 (IRS-1) and phosphotyrosine-associated PI 3-kinase but enhanced levels of IRS-2-associated PI 3-kinase and Akt activation, whereas in adipocytes levels of both insulin-stimulated PI 3-kinase and Akt are unchanged. Despite this, adipocytes of the knockout mice are smaller and have increased glucose uptake with altered glucose metabolic pathways. When treated with gold thioglucose, p50alpha/p55alpha knockout mice become hyperphagic like their wild-type littermates. However, they accumulate less fat and become mildly less hyperglycemic and markedly less hyperinsulinemic. Taken together, these data indicate that p50alpha and p55alpha play an important role in insulin signaling and action, especially in lipid and glucose metabolism.
The Uncatalyzed Exchange of Cl<sup>−</sup> and AuCl<sub>4</sub><sup>−</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTThe Uncatalyzed Exchange of Cl− and AuCl4−Ronald L. Rich and Henry TaubeCite this: J. Phys. Chem. 1954, 58, 1, 1–5Publication Date (Print):January 1, 1954Publication History Published online1 May 2002Published inissue 1 January 1954https://pubs.acs.org/doi/10.1021/j150511a001https://doi.org/10.1021/j150511a001research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Encapsulated Fe<sub>3</sub>O<sub>4</sub>/Ag Complexed Cores in Hollow Gold Nanoshells for Enhanced Theranostic Magnetic Resonance Imaging and Photothermal Therapy (2014)

Designed and fabrication of a novel magnetic hollow gold nanoshell complexes that incorporates iron oxide nanoparticles in the hollow interior. The combined effect of the smaller IONPs improved the overall magnetic properties of the design and MRI contrast capability. The overall complex could be synthesized in the range of 60-80 nm in diameter while still having a plasmonic peak in the near infrared region.
Synthesis of (Diethyl-<i>d</i><sub>10</sub>) Coumaphos and Related Compounds (2000)

Two deuterated insecticides were prepared for use as internal standards for gas-liquid chromatographic-mass spectrometric analyses. Diethyl chlorothiophosphate-d(10) was prepared by reaction of ethanol-d(6) with P(2)S(5) to give labeled diethyldithiophosphoric acid, followed by chlorination. Treatment of the acid chloride with 3-chloro-4-methyl-7-hydroxycoumarin and potassium carbonate in acetone at reflux gave labeled coumaphos. An analogous reaction with 4-methyl-7-hydroxycoumarin gave labeled potasan, and the technique should be usable for synthesis of labeled forms of other dialkyl thiophosphate insecticides.
Risk factors associated with ixodid tick species distributions in the Basque region in Spain (2006)

Ixodid tick abundance was investigated in the Basque region in Spain in two 1-year longitudinal studies, in 1992-1993 and 2003-2004. Forty zones were visited monthly and 162 672 ticks (87% larvae, 12% nymphs and 1% adults) were collected by blanket dragging. Eleven tick species belonging to the genera Ixodes, Haemaphysalis, Rhipicephalus and Dermacentor were identified including Haemaphysalis concinna Koch, which had not previously been reported in Spain. Tick species abundance differed between zones, studies and seasons. In 1992-1993, Haemaphysalis punctata Canestrini & Fanzago was the predominant species and distinct spring-summer and autumn-early winter peaks of activity were observed. In 2003-2004, Ixodes ricinus (Linneaus) was the most common species and was active throughout the winter. Larval and nymph seasonal activity patterns coincided in both 1993 and 2003 and this could facilitate co-feeding transmission of pathogens. Higher tick abundance was associated with increased livestock abundance in 1992-1993 and milder winter temperatures in 2003-2004. Tick collection rates in areas with moderate and high tick density were positively associated with the interaction between ambient temperature at sampling and rainfall 7 days prior to sampling. Collection rates were also significantly higher at medium rather than higher altitude, in forested areas than in open grasslands and lower in recreational areas frequented by people and with wet vegetation at sampling.
The Posterolateral Corner of the Knee: Evaluation Under Microsurgical Dissection (2005)

Being aware of the complex anatomy of the posterolateral corner and its variations may prove useful in repair and reconstruction.
Optical free-space board-to-board interconnect: options for optical pathways (1992)

The optical free-space interconnect is becoming increasingly important because of its high intrinsic density and routing capabilities. This paper deals with a free-space board-to-board interconnect, based on light-emitting diode arrays as sources. The design of the optical pathway is discussed, and some design rules and simulation results are presented. Two basic options (a lens array and a single lens) are evaluated, and their performance, in terms of power transfer, cross talk, and uniformity, are analyzed.
Supplementary Table 1 from High Phospho-Stathmin(Serine38) Expression Identifies Aggressive Endometrial Cancer and Suggests an Association with PI3K Inhibition (2023)

<p>PDF file - 50K, Primary investigation series. Cox's proportional hazard regression model used to estimate the prognostic value of pStathmin(S38) in endometrial carcinomas, in relation to histopathologic variables and Stathmin.</p>
The mechanism of intramolecular ‘citran’ bicyclisation of chromens: stereochemistry of a forward (H<sup>+</sup>catalysed) and a related reverse (thermal) process (1979)

Stereochemical evidence suggests that acid-catalysed citran formation proceeds via electrocyclisation of a dienone; pyrolysis of ‘farnesylidenemalonic acid’ proceeds with retention of configuration at the newly formed 8-olefin bond, indicating the operation of a retro-Diels–Alder process.
Top scoring pairs for feature selection in machine learning and applications to cancer outcome prediction (2011)

The k-TSP ranking algorithm can be used as a computationally efficient, multivariate filter method for feature selection in machine learning. SVM in combination with k-TSP ranking algorithm outperforms k-TSP and SVM alone in simulated datasets and in some cancer prognosis datasets. Simulation studies suggest that as a feature selector, it is better tuned to certain data characteristics, i.e. correlations among informative genes, which is potentially interesting as an alternative feature ranking method in pathway analysis.
Fiber Bragg gratings of type I in SMF-28 and B/Ge fibre and type IIA B/Ge fibre under gamma radiation up to 0.54 MGy (2005)

The sensitivities of type I and IIA fibre Bragg gratings written to different reflectivities in SMF-28 and B/Ge fibres to ionizing radiation up to 0.54MGy are investigated. The Bragg wavelength shows a small and rapid increase at the start of irradiation followed by either a plateau (type I) or a decrease (type IIA).