gebhart/patrepeval huggingface dataset:
Groundwater contamination with trichloroethylene: The problem and some solutions — A review (1993)

Abstract Numerous technologies are readily available for on‐site above‐ground treatment of ground water contaminated with TCE. Proper delineation of the extent of the contamination in the vadose and the saturated zones and bedrock remains the main problem responsible for the disappointing record of the full‐scale remediation efforts so far. A comprehensive approach is advocated that combines the pump‐and‐treat technology and in situ remediation, with particular emphasis on biological processes, as the least cost alternative.
ChemInform Abstract: Niobium‐Catalyzed Activation of Aryl Trifluoromethyl Groups and Functionalization of C—H Bonds: An Efficient and Convergent Approach to the Synthesis of N‐Heterocycles (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Neutronic analysis for Sandia Pulsed Reactor III (SPR III) (1976)

Robotics is a forward-looking discipline. Attention is focused on identifying the next grand challenges. In an applied field such as medical robotics, however, it is important to plan the future based on a clear understanding of what the research community has recently accomplished and where this work stands with respect to clinical needs and commercialization. This Review article identifies and analyzes the eight key research themes in medical robotics over the past decade. These thematic areas were identified using search criteria that identified the most highly cited papers of the decade. Our goal for this Review article is to provide an accessible way for readers to quickly appreciate some of the most exciting accomplishments in medical robotics over the past decade; for this reason, we have focused only on a small number of seminal papers in each thematic area. We hope that this article serves to foster an entrepreneurial spirit in researchers to reduce the widening gap between research and translation.
Development of safe optimized welding procedures for high strength Q&T steel welded with austenitic consumables (2013)

High strength quenched and tempered (Q&T) steels offer obvious economic benefits originating from their advantageous strength to price and weight ratios. These steels are usually welded using ferritic consumables and for this combination the risk of hydrogen assisted cold cracking (HACC) is high. The use of austenitic stainless steel (ASS) consumables has great potential to significantly improve this issue. Yet, there are no guidelines for determination of safe level of preheat for welding ferritic steels with ASS consumables. For this reason manufacturers adopt this parameter from procedures developed for conventional ferritic consumables thus significantly limiting the benefits ASS consumables are capable to deliver. Productivity could be further enhanced by identifying the upper interpass temperature threshold, thus reducing the stand-off times. Aim of this work is to develop safe highly optimised procedures for welding of high strength Q&T steel with ASS consumable.
Leukemia inhibitory factor induces apoptosis and proliferation of human carcinoma cells through different oncogene pathways (1997)

Leukemia inhibitory factor (LIF) affects the growth of carcinoma cells, and we thus analyzed its underlying mechanisms. Carcinoma cells constitutively express LIF mRNA, and 23 lines (92.0%) and all (100%) of 25 lines express LIF receptor mRNAs of LIFRβ and gp130, respectively. Exogenous addition of LIF promoted significant cell proliferation in 4 lines (MCF-7, ZR-75-1, Hs-700T and Panc-1) and suppressed cell growth in 3 lines (AZ-521, GBK-1 and HT-29). LIF significantly induced an immediate early response of genes c-fos and junB 3 hr after stimulation, but not of c-jun during the process of proliferation of MCF-7 and Hs-700T cells, with maximum levels at 30–60 min. The cell-cycle-related gene cyclin E was also induced in MCF-7 and Hs-700T cells, whereas cyclinA, cdk2, c-myc, c-myb and p53 mRNAs were not induced. On the other hand, LIF inhibited growth and increased the rate of cell death of AZ-521 and GBK-1 cells. LIF increased the number of TUNEL-positive cells in AZ-521 cells and DNA fragmentation in AZ-521 and GBK-1 cells. LIF induced apoptosis related genes c-myc and ICE during suppression of cell growth, but p53, p21, c-fos, cyclin A and cyclin E were not induced. Our results suggest that LIF is linked to cell proliferation and apoptosis in some human carcinoma cell lines. It is considered that this is related to differences in signal transduction and induction of oncogenes. Int. J. Cancer 72:687–695, 1997. © 1997 Wiley-Liss, Inc.
P4–016: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 2: Bridging subcutaneous to intravenous formulations for clinical trials (2013)

Allopregnanolone (Allo) stimulates proliferation of rodent and human neural progenitor cells in vitro and in triple transgenic Alzheimer's disease (3xTgAD) mice in vivo. Simultaneously, Allo reduces AD pathology and improves cognitive performance in 3xTgAD mice. Allo was administered to mice subcutaneously (SC; 10 mg/kg) or intravenously (IV; 0.01–1.5 mg/kg). Formulations of Allo were developed through solubility tests and dose range-finding and efficacy studies bridging to SC 10 mg/kg. The SC control formulation (10 mg/kg in PBS/5%EtOH) did not induce detectable sedation indicating that global neuroactivation of GABAergic pathways is not required for neurogenesis. In vitro, intracellular calcium rise occurs rapidly, within one-minute after Allo exposure, indicating that sustained activation of GABA A receptors may not be required. Once/week dosing regimen maximized neurogenesis while concomitantly reducing Alzheimer's pathology. Results of current analyses indicate promising therapeutic efficacy of soluble IV Allo to promote neuroregenerative capacity. Bridging studies were conducted to simulate SC with IV. IV Allo activates CREB and neuronal differentiation factors including NeuroD to promote neurogenesis within 24h and new cells integrate into pre-existing hippocampal neural networks within weeks following Allo exposure. Our preclinical data indicate that the regenerative effect of ALLO occurs at sub-sedative doses given in a regimen consistent with the time course for regeneration - i.e. maximum exposure of once per week - not daily as is typical for most therapeutics. Thirty minutes after IV (Allo 1.5 mg/kg) administration in the mouse, the plasma Allo concentration was 51 ng/ml (160 nmol/l) and 192 ng/g in brain cortex, comparable with our previously tested SC formulation (Allo 10 mg/kg) that reached 34 ng/ml (107 nmol/l) in plasma and 159 ng/g in brain cortex within 30 min thereby bridging IV and SC formulation and Allo exposure. PK/PD of Allo in mice and prior human exposure data were used to determine an IV dosing regimen and predicted human exposure in support of planned clinical trials in Alzheimer's patients. Allo formulations via IV and SC routes of administration induce the regenerative capacity of the brain.
Dioxins in organic eggs: a review (2006)

Eggs contribute for about 4% to the daily dioxin intake of humans. Research among layer farms in the Netherlands and other EU countries has shown that organic eggs contain more dioxin than conventional ones and that a significant number of organic farms produce eggs with a dioxin content that exceeds the EU standard. The hens' intake of dioxins from various sources leads to an increase in the dioxin content of organic eggs. These sources include plants, feed, soil, worms and insects, and compared with hens on conventional and free-range farms, organic hens make more use of these sources due to better access to the outdoor run. Plants appear to be relatively unimportant as a source of dioxins. Also commercial organic feed generally has very low dioxin contents, but not much is known about non-commercial feed. Consumption of worms and insects and particularly ingestion of soil are important causes of high dioxin levels in eggs. Management interventions, like a reduction of the time the hens spend outside, may decrease the dioxin levels in organic eggs but at the same time may interfere with the image of the organic production system.
Gemogenovatucel-T (Vigil) maintenance immunotherapy: 3-year survival benefit in homologous recombination proficient (HRP) ovarian cancer (2021)

In conclusion, results suggest durable activity of Vigil on RFS and OS and support further evaluation of Vigil in HRP ovarian cancer.
Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death. (1997)

Recent evidence suggests that members of the interleukin-1-beta-converting enzyme (ICE)/Ced-3 family are key mediators of mammalian apoptosis. The known members of the ICE/Ced-3 cysteine protease family are synthesized as proenzymes and require proteolytic processing to produce active, heterodimeric enzymes. The baculovirus protein P35 has recently been shown to inhibit several members of the ICE/Ced-3 cysteine protease family. The importance of ICE/Ced-3 cysteine proteases in programmed cell death prompted us to investigate the role of the apoptotic mediator, CPP32, in the glucocorticoid-mediated cell death pathway. Glucocorticoids induce growth inhibition and apoptosis in sensitive leukemic cell lines, immature thymocytes, and eosinophils. In this report, we demonstrate the enzymatic cleavage of proCPP32 to its active subunits in cells undergoing glucocorticoid-induced apoptotic cell death. Concurrently, in apoptotic cells, PARP, a 116-kilodalton (kDa) human poly(ADP-ribose) polymerase, is proteolytically cleaved to its signature 85-kDa fragment. The proteolytic processing of PARP (the nuclear DNA repair enzyme known to be cleaved in association with apoptosis) is catalyzed by members of the ICE/Ced-3 family. Importantly, stable transfection of the antiapoptotic baculovirus P35 inhibits glucocorticoid-induced apoptotic cell death, proteolytic processing of proCPP32, and cleavage of the 116kDa PARP. We conclude that activation of CPP32 is a critical event in glucocorticoid-induced apoptosis and that this pathway is inhibited at or upstream of CPP32 by baculovirus P35. These data demonstrate that PARP cleavage occurs during glucocorticoid-induced apoptotic cell death and show that this proteolytic process is blocked by the expression of baculovirus P35, supporting a role for activation of the ICE/Ced-3-like cysteine protease during glucocorticoid-induced apoptosis.
E-128 Intraprocedural blood pressure and outcome after mechanical thrombectomy (2018)

<h3>Introduction</h3> Despite substantial evidence of the association between intra-procedural blood pressure and functional outcome in patients undergoing mechanical thrombectomy (MT) under general anesthesia, little is known about the relationship between intraprocedural blood pressure and this outcome in patients undergoing MT under monitored anesthesia care (MAC). <h3>Objective</h3> To investigate the association of different intraprocedural blood pressure parameters with functional outcome and the risk of hemorrhagic transformation (HT) in patients undergoing MT under MAC. <h3>Methods</h3> We retrospectively reviewed patients who underwent MT between 11/1/2014 and 2/1/2017. Blood pressure was recorded at 3–5 min intervals during MT. We used logistic regression to measure the association for each of mean, maximum, and minimum systolic, diastolic, and mean arterial blood pressures with functional and safety outcomes. <h3>Results</h3> 155 patients were included in the study. Seventy patients (45.2%) achieved a good outcome (mRS 0–2). The good outcome group was younger (60.7 vs 72.2 years; p<0.01) and had lower NIHSS score (13.7±6.3 vs 17.2±6; p<0.01). None of the intraprocedural blood pressure parameters correlated with the functional outcome. However, there was a trend towards a higher SBP in the poor outcome group (mean SBP 159.6±22.1 mm Hg vs 153±19.1 mm Hg; p=0.0508). Only mean SBP correlated with the risk of HT (OR for 10 mm Hg increment, 1.2; 95% CI 1.01–1.42). <h3>Conclusion</h3> Our study did not show a significant correlation between intraprocedural blood pressure and functional outcome in patients who underwent MT under MAC. However, we demonstrated a significant correlation between higher mean SBP and risk of HT. <h3>Disclosures</h3> <b>M. Anadani:</b> None. <b>S. Ajinkya:</b> None. <b>A. Alaweih:</b> None. <b>J. Vargas:</b> None. <b>A. Chatterjee:</b> None. <b>R. Turner:</b> 6; C; Codman Consulting, Honorarium, Speaker Bureau, Research Funding; Covidien Consulting, Honorarium, Speaker Bureau; Penumbra Consulting, Honorarium, Speaker Bureau, Research Grants; Microvention Consult. <b>M. Chaudry:</b> 6; C; Codman Consulting, Honorarium, Speaker Bureau, Research Funding; Covidien Consulting, Honorarium, Speaker Bureau; Penumbra Consulting, Honorarium, Speaker Bureau, Research Grants; Microvention Consult. <b>A. Turk:</b> 6; C; Codman Consulting, Honorarium, Speaker Bureau, Research Funding; Covidien Consulting, Honorarium, Speaker Bureau; Penumbra Consulting, Honorarium, Speaker Bureau, Research Grants; Microvention Consult. <b>A. Spiotta:</b> 6; C; Penumbra Consulting, Honorarium, Speaker Bureau; Pulsar Vascular Consulting, Honorarium, Speaker Bureau; Microvention Consulting, Honorarium, Speaker Bureau, Research; Stryker Consulting, Honorarium.
A solution for navigating user-generated content (2009)

We are interested how to contextualize the digital content of an individual user with the help of content from other users, how to create a positive user experience from that, and what kind of interaction that can encourage between users. As a result the environment can be modelled. Creating a digital representation of the world from photographs is an exciting opportunity, for e.g. as a registering system for Augmented Reality (AR), forming one cornerstone for what Hollerer et al. call Anywhere Augmentation (AA). In this paper we present the user experience of the prototype and its key features. We have implemented a prototype solution for discovering shared digital media via a novel user interface, presenting the spatial relationships of the content.
High-Voltage MOSFET Model Valid for Device Optimization (2009)

We have developed the high-power MOSFET model HiSIM_HV based on the complete surface-potential-based description. It is demonstrated here that HiSIM_HV is suitable even for device optimization.
Autonomic regulation of colonic epithelial and motor function (1996)

Physiologic regulation of colonic function depends on the interaction among three systems: enteric, autonomic (sympathetic and parasympathetic), and immune. Visceral sensory information is transmitted via primary afferents and integrated at central (spinal and supraspinal) sites. Changes in the activity of these primary afferents are an important component in pathophysiologic alterations of colonic motor and secretory functions and seem to be a common mechanism underlying functional disorders of the gastrointestinal tract. Increased colorectal sensitivity to distention in irritable bowel syndrome may involve alterations of thoracolumbar afferents and the immune system in the colonic wall. Alterations in the properties of the enteric nervous system, epithelial transport, and somatic and visceral responses to visceral pain have been characterized during immune challenges and experimental colitis.
Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function (2008)

We propose that lower HDAC6 levels combined with decreased microtubule binding lead to increased tubulin acetylation in ethanol-treated cells.
The role of KRAS mutations in resistance to EGFR inhibition in the treatment of cancer. (2009)

The development of EGFR inhibitors has influenced the field of targeted therapeutics significantly. Unfortunately, the benefits of EGFR inhibitors are limited by several mechanisms of drug resistance, which include KRAS mutations. Mutations in this gene result in constitutive activation of the Ras/Raf/MEK/ERK pathway, with loss of EGFR signaling control, rendering inhibitors of EGFR ineffective. Several strategies are being developed to overcome this mechanism of resistance, including MEK inhibitors, Braf inhibitors, Hsp90 inhibitors, K-Ras-directed immunotherapy, mTOR inhibitors and several combination approaches.
Magnetic forces and vibrational behavior analysis for flux switching permanent magnet machines (2012)

This paper deals with the magnetic forces and the mechanical behavior of flux switching permanent magnet (FSPM) machines. First, we will focus on the origin of magnetic stresses in the FSPM machine. Secondly we will realize a FEM analysis to observe these stresses in two locations (at the air / teeth interface and at the permanent magnets / iron interface) when the FSPM machine is unloaded and loaded. Then, we will consider the expression of the stator deformation. Finally, eigenmodes of this structure obtained by FEM analysis will be presented and compared to experimental measure.
Influence of Cell Cycle Phase on Radiation-Induced Cytotoxicity and DNA Damage in Human Colon Cancer (HT29) and Chinese Hamster Ovary Cells (1994)

We have previously shown that fluorodeoxyuridine (FdUrd) radiosensitizes HT29 human colon carcinoma cells. Since treatment with FdUrd arrests cells at the G1/S-phase interface, a condition associated with increased radiation sensitivity in some cells, it seemed possible that redistribution of cells in the phases of the cell cycle might account for FdUrd-mediated radiosensitization. To begin to test this, HT29 cells were separated by centrifugal elutriation according to cell cycle phase and assessed for radiosensitivity, using a clonogenic assay, and radiation-induced DNA damage, using pulsed-field gel electrophoresis. We found that all of the elutriated fractions (which contained cells enriched in G1, G1/early S, mid to late S or G2/M phase) had the same radiation sensitivity and expressed a similar extent of radiation-induced DNA damage. To determine if the techniques used in this study could detect differences between the radiation sensitivity of cells in different phases of the cell cycle, analogous experiments were carried out using Chinese hamster ovary (CHO) cells. In contrast with the results of experiments with HT29 cells, but in agreement with previous studies, CHO cells separated under the same conditions as were used for HT29 cells showed a marked dependence on cell age of both clonogenic survival and radiation-induced DNA damage. Thus, within the limitations of the purity of separation obtained using elutriation, the radiation sensitivity of HT29 cells does not vary substantially as a function of cell cycle phase. Therefore, it seems unlikely that cell cycle redistribution alone explains the radiation sensitivity produced by exposure to FdUrd.
Characterization of the human T cell response to antigen 5 from <i>Vespula vulgaris</i> (Ves v 5) (2005)

Our findings provide evidence that the allergic T cell response to Ves v 5 is not Th2-dominated and that different immunogenic sites on this major wasp venom allergen are recognized by allergic and non-allergic individuals.
THE INDO-PACIFIC GEMMULA SPECIES IN THE SUBFAMILY TURRINAE: ASPECTS OF FIELD DISTRIBUTION, MOLECULAR PHYLOGENY, RADULAR ANATOMY AND FEEDING ECOLOGY. (2010)

The biology, feeding ecology and phylogenetic relationships of marine snails in the family Turridae remain poorly understood. Here we report our study on four deep-water species in the genus Gemmula, a major group in this family. The four species G. speciosa (Reeve 1843), G. sogodensis (Olivera 2005), G. kieneri (Doumet 1940) and G. diomedea (Powell 1964) were collected at five different sites in the Philippines, and their pattern of distribution in the sites, their feeding behaviour as well as their phylogenetic relationships with each other and with other members of the subfamily Turrinae were investigated. The radular morphology (of two Gemmula species) and potential prey (for one Gemmula species) were also examined. Actual feeding observations were also conducted for Gemmula speciosa and compared with two turrids from other genera.All four Gemmula species showed strikingly different patterns of distribution; each species was found to be relatively much more abundant at one site but not at the other sites. Molecular phylogenetic analysis based on 16S sequences correlated with previously reported 12S sequences and revealed that the four species all belong to a well-supported Gemmula clade within the subfamily Turrinae; and that this clade appeared more closely related to the clades Xenuroturris, Turris and Lophiotoma than to the other clades in the subfamily (i.e., Turridrupa, Unedogemmula and Polystira). Morphological analysis of the radula of both G. speciosa and G. sogodensis revealed that the radulae of the two species were similar but differed from the other turrids, Lophiotoma acuta and Unedogemmula bisaya, by the absence of central teeth, consistent with the separation of the Gemmula clade from the Lophiotoma and Unedogemmula clade.To identify the polychaete group that is targeted as prey by species of Gemmula, analysis of regurgitated food fragments was made; phylogenetic analysis of an mtCOI gene fragment that was PCR-amplified from the regurgitated tissue of one specimen (G. diomedea) indicated close affinity of the prey to the terebellid polychaete Amphitritides. Specimens of Gemmula speciosa, when challenged with the terebellid polychaete Loimia sp., were observed to attack the worm suggesting that Gemmula species feed on terebellid polychaetes. Lophiotoma acuta were also observed to feed on the same species of terebellid but were usually group-feeding in contrast to the solitary feeding of G. speciosa. Unedogemmula bisaya did not feed on the terebellid which also supports the separation of the Gemmula and Unedogemmula clade.Two lines of proof (i.e. the molecular phylogenetic analysis and the feeding challenge) supporting the toxin homology findings previously reported, provide consistent evidence that Gemmula is a distinct clade of worm-hunting Turrinae that feeds on Terebellidae.
<title>Multiuser facilities for microscopic imaging</title> (1997)

During the last ten years, microscopy as a scientific tool has reinvented itself. It has changed from a group of principally descriptive methodologies, to a wide range of primary tools and techniques to investigate the molecular organization of organs, tissues and cells. Advances in microscope and camera design, fluorescent dye technologies as well as the advent of inexpensive powerful computers, has made the simultaneous resolution and quantification of multiple concurrent molecular markers for both protein and DNA at a sub-micron resolution a reality. Furthermore, it is possible to probe living cells using a rapidly expanding repertoire of dyes sensitive to changes pH or concentration of specific intracellular ions. An essential extension of these techniques has been the development of methods which allow the distribution of proteins and mRNA to be studied within cells at a molecular resolution by EM. However, concurrent with these developments there has been a more dramatic increase in the level of expertise needed to successfully design experiments, implement these technologies and costs involved in purchasing and maintaining instrumentation. These developments have resulted in a situation such that it is no longer tenable for individual departments or possibly institutions to maintain independent imaging facilities, and centralized resources have become mandatory in order to stay at the cutting edge. This presentation will discuss the problems, pitfalls and advantages of a centralized system, and will focus on implementation, design, data handling, and management of a multi-user facility.