gebhart/patrepeval huggingface dataset:
Emerging Models for Global Health in Radiation Oncology (2016)

In response to the growing global health challenge in the fight against cancer, there is now a greater need for radiation oncology health professionals across institutions to collaborate and be more globally engaged. <i>Emerging Models for Global Health in Radiation Oncology</i> is a response to the need for a book that comprehensively covers the important and emerging field of radiation oncology. This insightful book highlights the emerging models for global radiation oncology, and serves as a useful resource to facilitate participation and greater effective collaborative global cancer care, research, and education. It is suitable for researchers, students, health professionals, and anyone interested in the global oncology community.
Repaired aortic coarctation in adults—magnetic resonance imaging with velocity mapping shows distortions of anatomy and flow (1996)

Abstract Magnetic resonance velocity mapping of intraaortic flow was performed prospectively in adolescents and adults after coarctation repair. The aims were to assess the feasibility and clinical usefulness of the technique in this patient group, and to study flow velocity distributions in repaired regions. Twenty consecutive patients attending for follow-up after repair of aortic coarctation, aged 15–39, mean 25 years, were studied using a 0.5 tesla Picker magnetic resonance machine. Spin echo and cine imaging with phase velocity mapping, echo time 3.6 ms, were used to study anatomy and flow in the repaired region. Transcutaneous ultrasonic examination, with continuous wave Doppler velocity measurement was performed independently on the same day. Velocity maps, acquired successfully in all patients, showed asymmetry and nonhomogeneity of flow in relation to anatomical distortions of repaired regions. Magnetic resonance and Doppler measurements of peak velocity compared as follows: n=20, range 1.2–3.9 m/sec, mean 2.33 m/sec, mean of differences (Doppler-MR) 0.22 m/sec, standard deviation of differences ±0.27 m/sec. Localized velocity peaks adjacent to wall deformations were identified by magnetic resonance in five patients without significant restenosis. Magnetic resonance imaging with velocity mapping proved reliable and informative in follow-up assessment in adolescents and adults after surgical repair of aortic coarctation. There was satisfactory agreement between magnetic resonance and Doppler measurements of peak velocity. Velocity maps showed that localized velocity peaks may occur in limited parts of the stream adjacent to distorted aortic boundaries without stenosis. This could be a cause of overestimation of pressure gradients from peak velocity data, a possibility which requires further investigation.
A Case of Duodenal Flat Adenoma Completely Removed by Endoscopic Mucosal Resection (1995)

A 60-year-old man was admitted to our hospital because of a flat lesion at the anal side of supra duodenal angle. This lesion was pointed out by screening upper GI endoscopy. The follow-up examination showed the adenoma with severe atypia. Tumor was 15×10mm in size with eroded surface. After spraying indigocalmin, this lesion was clearly identified. Endoscopic ultrasonograpy revealed the adenoma was located within duodenal mucosa. The endoscopic mucosal resection (EMR) was successfully done, the resected specimen was 18×15×3mm in size and histological examination revealed 7×3mm flat type of adenoma. The over expression of p53 by using immunohistochemistry was not observed in the tissue. Reported case of flat adenoma was relatively rare. There was 6 cases in Japanese literature (during 1956-1993 period) .
A comparison between iris‐ciliary body concentration and receptor affinity of timolol (1985)

Topical unilateral application of timolol reduces the IOP (intraocular pressure) of both the treated and the untreated eye. For this reason, a cental mechanism of action, in addition to the local one, has been suggested for the reduction of IOP by this drug. In this study timolol concentrations in the iris-ciliary body of the treated and untreated rabbit eyes were compared with pharmacologically active in vitro timolol concentrations. The drug concentration in the untreated eye too was found to be high enough to exert a local action.
Ramp Tests: A Novel Approach to VIV Model Testing of Flexible Cylinders Using Continuously Varying Towing Speeds (2015)

In this paper we present a small portion of the results from the 2011 SHELL tests at the MARINTEK basin. The tests involved towing densely instrumented flexible cylinders at Reynolds numbers up to 150,000 in order to study the Vortex-Induced Vibration (VIV) response in uniform current profiles. This paper presents the experimental results collected from a series of tests where the towing speed was continuously varied while the cylinder and carriage traversed the basin. As the cylinder is accelerated (or decelerated) the incident current speed is continuously changing which means that multiple modes can be excited consecutively in a single tow through the basin. These varying towing speed tests are collectively referred to as ‘ramp tests’. The response data collected in these ‘ramp tests’ are presented in terms of CF response amplitudes and strains and are carefully compared with the response data collected during conventional steady towing speed tests. The data shows that when the acceleration of the carriage is kept below a critical value the ‘ramp tests’ are then able to provide VIV response information which is equivalent to that obtained from many constant speed tests. One ramp test provides the equivalent response data of (up to) 10 constant speed tests in a single run. This paper also introduces a dimensionless parameter γ, which determines if the proposed acceleration for a ramp test is within acceptable limits and may be used as a substitute for many constant speed tests. The parameter can be used to determine the appropriate acceleration or deceleration rate in order to ensure that a ramp test will yield suitable VIV response data. The parameter also allows one to know quickly whether or not fully developed VIV is possible in a given set of unsteady flow conditions.
Endoplasmic Reticulum/Golgi Nucleotide Sugar Transporters Contribute to the Cellular Release of UDP-sugar Signaling Molecules (2009)

Extracellular UDP-sugars promote cellular responses by interacting with widely distributed P2Y(14) receptors, but the mechanisms by which these molecules are released from cells are poorly understood. Given the active role of UDP-sugars in glycosylation reactions within the secretory pathway, we hypothesized that UDP-sugar release includes an exocytotic component. This hypothesis was tested by assessing the contribution of endoplasmic reticulum (ER)/Golgi-resident UDP-GlcNAc transporters to the cellular release of their cognate substrates. A sensitive and highly selective assay for UDP-GlcNAc mass was developed using purified AGX2, an isoenzyme of human UDP-GlcNAc pyrophosphorylase. Robust constitutive release of UDP-GlcNAc was observed in yeast as well as in well differentiated human airway epithelial cells. The human UDP-GlcNAc transporter HFRC1 was overexpressed in human bronchial epithelial cells and was shown to localize in the Golgi and to enhance the surface expression of N-acetylglucosamine-rich glycans. HFRC1-overexpressing cells also displayed increased constitutive and hypotonic stress-stimulated release of UDP-GlcNAc. Yeast mutants lacking Yea4 (the ER UDP-GlcNAc transporter endogenously expressed in Saccharomyces cerevisiae) showed reduced UDP-GlcNAc release. Yea4-deficient cells complemented with Yea4 showed UDP-GlcNAc release rates at levels similar to or higher than wild type cells. Our results illustrate that ER/Golgi lumen constitutes a significant source of extracellular UDP-sugars and therefore plays a critical role in nucleotide sugar-promoted cell signaling.
Severe position effects imposed on a 1 kb mouse whey acidic protein gene promoter are overcome by heterologous matrix attachment regions (1996)

Matrix attachment regions (MARs) have been shown to participate in the insulation of transcription elements from surrounding chromatin in tissue culture cells and transgenic mice. A whey acidic protein (WAP) transgene containing 1 kb promoter sequence was active in mammary tissue from 1 out of 17 lines of mice, demonstrating that the transcription elements were highly susceptible to position effects. To test whether MARs could insulate this WAP gene promoter and thereby restore transcription, we ligated MARs from the chicken lysozyme gene to the WAP transgene. Seven of the nine lines generated exhibited WAP transgene activity, expression was confined to mammary tissue, and correct regulation was observed in three of the four lines analyzed. This study provides strong additional evidence that the MAR fragments from the chicken lysozyme gene have the capacity to insulate transgenes from severe position effects.
[Evaluation of hemoglobin dextran 10-benzene-tetracarboxylate, oxygen transporters, using a model of guinea pig intestine]. (1995)

With the aim of assessing of dextran-benzene-tetracarboxylate hemoglobin as an oxygen carrier, we studied histological changes in the intestinal loop. The intestinal tissue being very sensitive to hypoxia, in the anesthetized guinea pig, an innervated loop was vascularly perfused with open-flow during one hour at zero hematocrit. To estimate the capacity of hemoglobin solution to oxygenate this tissue, we observed the mechanical and histological changes in the organ and the arterio-venous difference in PO2, oxyhemoglobin, deoxyhemoglobin and we compared them with human albumin, Tyrode and non-modified hemoglobin. The PO2 arterio-venous differences were 51.9 +/- 7.1 torr (m +/- SEM) for Tyrode, 40.2 +/- 6.4 torr for albumin solution, 113.7 +/- 6.5 torr for non-modified hemoglobin and 123.1 +/- 7.9 torr for dex-BTC-Hb. Compared to albumin and Tyrode solutions, hemoglobin solutions transferred more oxygen to tissues. The desaturation of dex-BTC-Hb was significantly superior (p < 0.05) to the one non-modified hemoglobin. The structure of jejunal villi when perfused with a hemoglobin solution, remained almost normal and the loop was still active. Nevertheless, non-modified hemoglobin leaked from the vessels to the lumen and caused oedema and a rupture of overlapping epithelium at the tip of the villi. With dex-BTC-Hb, such histological modifications were less significant. With albumin and Tyrode, all villi were totally necrosed and the loop was completely inert. We have demonstrated that dextran-benzene-tetracarboxylate hemoglobin had the ability to maintain the tissue alive thank to its good capacity to release oxygen and its satisfactory vascular persistence.
Identification of Asparagine as the Site of Glycosylation in Glycoprotein Biosynthesis* (1973)

Journal Article Identification of Asparagine as the Site of Glycosylation in Glycoprotein Biosynthesis Get access Michiaki KOHNO, Michiaki KOHNO Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto UniversityKyoto Search for other works by this author on: Oxford Academic PubMed Google Scholar Ikuo YAMASHINA Ikuo YAMASHINA Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto UniversityKyoto Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 73, Issue 5, May 1973, Pages 1089–1094, https://doi.org/10.1093/oxfordjournals.jbchem.a130163 Published: 01 May 1973 Article history Received: 08 December 1972 Published: 01 May 1973
[Effect of anoxia on the evoked somesthesic response during rabbit maturation]. (1975)

The resistance to anoxy of the somesthetic evoked response (S.E.R.) has been studied on the young rabbit from birth to ten days. An obvious decrease of this resistance is being observed from the eighth day. The authors drew a parallel from their results and the well known modifications of the oxydative metabolism of the C.N.S. during maturation.
The role of location in everyday experiences of music. (2014)

Mehrabian and Russell’s (1974) Pleasure-Arousal-Dominance model states that a propensity to approach/avoid an environment can be conceptualized in terms of the pleasure and arousal it elicits and one’s degree of dominance therein. Using the Experience Sampling Method, 177 individuals provided responses concerning Mehrabian and Russell’s model throughout one week regarding music experiences that occurred in their daily life (including how the music was heard and how their responses related to the listening location). Results indicate that the time of day and day of week are related to where music is experienced, and that the consequences of what was heard are related to both time and location. While music was experienced more often in private locations than in public overall, interesting patterns of music experiences that occurred in public locations demonstrate in detail how music listening varies by location. Specifically, portable devices were associated with positive responses, which contrasted sharply with the responses to music broadcasted publicly in public settings. Participants’ ratings of choice, liking, and arousal demonstrated the importance of considering choice as an indication of dominance, such that music usage is consistent with Mehrabian and Russell’s model, and has functions that vary according to the specific characteristics of the situation.
Performance of NAS parallel application-benchmarks on IBM SP1 (2002)

We present the performance of three application benchmarks (BT, LU, and SP) from the NAS Parallel Benchmark suite on the IBM scalable POWERparallel 1 (SP1) system. We present performance results on both Class A and Class B problem sets. We compare the performance of two communication protocols, MPL and MPL/p, and also present results on a cluster of workstations called PPP. We describe the implementation of one of the benchmarks (SP) in some detail.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nitro enol, 3-hydroxy-4-nitro-5-phenyl-3-pyrrolin-2-one, and its reactive methyl ether (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitro enol, 3-hydroxy-4-nitro-5-phenyl-3-pyrrolin-2-one, and its reactive methyl etherPhilip L. Southwick, James A. Fitzgerald, R. Madhav, and David A. WelshCite this: J. Org. Chem. 1969, 34, 11, 3279–3285Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://pubs.acs.org/doi/10.1021/jo01263a013https://doi.org/10.1021/jo01263a013research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Crystallization and preliminary X‐ray diffraction studies of peroxidase from a fungus <i>Arthromyces ramosus</i> (1993)

Peroxidase (donor: H2O2 oxidoreductase [EC 1.11.1.7]) was purified from the culture broth of the hyphomycete Arthromyces ramosus in the early log phase to show a single band on SDS-PAGE. The crystals of A. ramosus peroxidase (ARP) were formed by salting out with ammonium sulfate at room temperature and pH 7.5. The repeated seeding technique was employed to grow the crystals to the size large enough for X-ray diffraction study. The crystals were characterized as tetragonal, space group P4(2)2(1)2, with unit cell dimensions of a = b = 74.5 A, c = 117.6 A. The asymmetric unit contains one molecule of peroxidase. They diffract X-rays to at least 2.0 A resolution and are stable to X-rays.
Identification and Characterization of Two Temperature-Induced Surface-Associated Proteins of <i>Streptococcus suis</i> with High Homologies to Members of the Arginine Deiminase System of <i>Streptococcus pyogenes</i> (2002)

The present study was performed to identify stress-induced putative virulence proteins of Streptococcus suis. For this, protein expression patterns of streptococci grown at 32, 37, and 42 degrees C were compared by one- and two-dimensional gel electrophoresis. Temperature shifts from 32 and 37 to 42 degrees C induced expression of two cell wall-associated proteins with apparent molecular masses of approximately 47 and 53 kDa. Amino-terminal sequence analysis of the two proteins indicated homologies of the 47-kDa protein with an ornithine carbamoyltransferase (OCT) from Streptococcus pyogenes and of the 53-kDa protein with the streptococcal acid glycoprotein (SAGP) from S. pyogenes, an arginine deiminase (AD) recently proposed as a putative virulence factor. Cloning and sequencing the genes encoding the putative OCT and AD of S. suis, octS and adiS, respectively, revealed that they had 81.2 (octS) and 80.2% (adiS) identity with the respective genes of S. pyogenes. Both genes belong to the AD system, also found in other bacteria. Southern hybridization analysis demonstrated the presence of the adiS gene in all 42 serotype 2 and 9 S. suis strains tested. In 9 of these 42 strains, selected randomly, we confirmed expression of the AdiS protein, homologous to SAGP, by immunoblot analysis using a specific antiserum against the SAGP of S. pyogenes. In all strains AD activity was detected. Furthermore, by immunoelectron microscopy using the anti-S. pyogenes SAGP antiserum we were able to demonstrate that the AdiS protein is expressed on the streptococcal surface in association with the capsular polysaccharides but is not coexpressed with them.
Errata: Transparent electrodes based on two-dimensional Ag nanogrids and double one-dimensional Ag nanogratings for organic photovoltaics (2015)

The <i>Journal of Photonics for Energy</i> (JPE) covers fundamental and applied research areas focused on the applications of photonics for renewable energy harvesting, conversion, storage, distribution, monitoring, consumption, and efficient usage.
Unraveling the Optoelectronic and Photochemical Behavior of Zn<sub>4</sub>O-Based Metal Organic Frameworks (2011)

Zn4O clusters corresponding with those present in MOF-5, IRMOF-8, and IRMOF-9 have been synthesized as monounits with the respective monodentate organic linkers attached. Ultraviolet (UV) absorption analysis of synthesized clusters and metal organic frameworks (MOFs) reveals that the organic moieties in the MOFs lose their individual absorption and emission characteristics, in contrast with their subunits which retain these characteristics. Observed photoluminescence (PL) quantum yields of the MOFs are higher than those of their corresponding subunits. This is explained by the isolation of clusters in monounits, where linkers are only attached to one cluster, resulting in greater charge localization compared to MOFs. The photocatalytic activity of the clusters in the nonporous monounits crystals turned out to be higher than that of their MOF counterparts and that of zinc oxide in the oxidation of propene at room temperature under UV illumination. Clearly porosity does not offer in this case any significant advantage in contrast to charge localization at Zn4O clusters. This observed difference in photocatalytic activity was found to be inversely proportional to the difference in PL quantum yields between monounits and MOFs, highlighting competition between decay of excited states by photon emission and electron transfer. Detection of the same products of partial oxidation with similar selectivities for the crystals of the synthesized monounits as well as for the MOFs led to the conclusion that Zn4O clusters in the monounits are in fact photochemical equivalents of those in their corresponding MOFs.
Integrated lightwave millimetric single side-band source: design and issues (1998)

We report on a fully integrated lightwave single side-band (SSB) source optimized for millimeter-wave (20-40 GHz) transport over fiber with no chromatic dispersion penalty. The operation principle is first developed. A practical design is proposed and tolerances of multimode interference (MMI) couplers and electroabsorption (EA) modulators subcomponents are theoretically and experimentally examined. The phase tolerances of MMI couplers are in particular given for the first time for such a scheme. These results imply the achievement of fully integrated rugged SSB source without resorting to complex technology steps.
Walking machine driven by a light beam (2001)

Optically driven small machines have such features as easily miniaturized in fabrication and as controlled by optical energy supplied in wireless. We report an optically controlled machine which moves like a catepillar on the basis of photo-thermal effect. This miniaturized machine fundamentally consists of two parts: a body made of shape memory alloys and springs and feet made of magnets and temperature-sensitive ferrites. Th effect can stick to the carbon steel floor due to magnetic force balance caused by projected beam, and the body repeats stretching and shrinking using deformation of shape memory alloys caused by switching on and off of projected beam. A prototype is fabricated in trial with a size of 35 mm by 12 mm. As an experimental result, it proved that they could move at the speed of 8.7 mm per cycle on a ceiling as well as on a horizontal floor and it could climb a slope as steep as 50 degree. To improve the ability of this prototype, we newly developed a smaller machine with the total length of 20 mm by 15 mm and the weight of 1.1 g. Because of lighter weight of this machine, it could climb any slope including a vertical wall.
Comparison of peer and citation assessment of the influence of scientific journals (1980)

Abstract A survey was undertaken to ascertain the extent of agreement between scientists' subjective assessment of the average influence per article for articles in 58 different scientific journals, when compared with corresponding citation influence ratings for articles in the same journals. The scientists' assessments were derived from questionnaires sent to faculty at 97 American universities covering journals in ten different research fields. A strong positive relationship was found to exist between the scientists' assessment of journal influence and the citation influence ratings, with product‐moment and Spearman rank correlations in the 0.7–0.9 range for seven of the ten fields.
Reaction of Nitrite With Ascorbate and Its Relation to Nitrosamine Formation2 (1975)

In this study of the nitrosation of morpholine in the presence of ascorbic acid, the amount of ascorbate required to inhibit completely the formation of nitrosomorpholine depended on whether oxygen was present in the system. The nitric oxide (produced during the oxidation of ascorbate by nitrous acid) might have reacted with oxygen to yield additional oxidizing equivalents, or oxygen might have directly oxidized the ascorbate semiquinone intermediate produced in the initial step of oxidation reaction. A pH- dependent induction period observed during the nitrosation of morpholine in the presence of ascorbate and excess nitrite was accounted for by the kinetics of the reactions.