gebhart/patrepeval huggingface dataset:
SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening (2016)

SwissSimilarity is a new web tool for rapid ligand-based virtual screening of small to unprecedented ultralarge libraries of small molecules. Screenable compounds include drugs, bioactive and commercial molecules, as well as 205 million of virtual compounds readily synthesizable from commercially available synthetic reagents. Predictions can be carried out on-the-fly using six different screening approaches, including 2D molecular fingerprints as well as superpositional and fast nonsuperpositional 3D similarity methodologies. SwissSimilarity is part of a large initiative of the SIB Swiss Institute of Bioinformatics to provide online tools for computer-aided drug design, such as SwissDock, SwissBioisostere or SwissTargetPrediction with which it can interoperate, and is linked to other well-established online tools and databases. User interface and backend have been designed for simplicity and ease of use, to provide proficient virtual screening capabilities to specialists and nonexperts in the field. SwissSimilarity is accessible free of charge or login at http://www.swisssimilarity.ch .
A homologue of elongation factor 1γ regulates methionine sulfoxide reductase A gene expression in <i>Saccharomyces cerevisiae</i> (2003)

Methionine sulfoxide reductase A (MsrA) maintains the function of many proteins by reversing oxidation of methionine residues. Lack of this repair mechanism very likely increases aging-related disease susceptibility. In Saccharomyces cerevisiae, disruption of the msrA gene increases free and protein-bound methionine sulfoxide and decreases cell viability. Although the underlying mechanisms in the induction of the msrA gene are still unknown, a transcriptional regulation may be involved. Hence, a search of nuclear proteins regulating the msrA gene is a major target of the experiments reported in this article. Using protein purification combined with MS, we discovered that calcium phospholipid-binding protein (CPBP), a homologue of elongation factor-1 gamma, is a component of a complex that binds to the msrA promoter. By measuring CPBP cooperative binding to the msrA promoter, we have mapped the CPBP binding site to a 39-bp sequence at the 3' end of the promoter. In a mutant yeast strain lacking the CPBP-encoding gene, the ability to overexpress msrA mRNA and MsrA protein was impaired and MsrA catalytic activity was greatly reduced, suggesting that CPBP may enhance msrA gene expression.
Lifetime Measurements of Several S, P, and D States of Thallium in a Glow Discharge by Single-Step and Two-Step Laser-Excited Fluorescence (2008)

The lifetimes of several states in a thallium see-through hollow cathode discharge, or galvatron, are obtained to characterize its potential as an atomic line filter. The lifetimes of the thallium 6(2)D(3/2), 6(2)D(5/2), and 7(2)S(1/2) states are measured by time-resolved single-step laser-excited fluorescence by use of a 276.787 nm laser pulse or a 535.046 nm laser pulse and measuring the resulting fluorescence waveform at the appropriate wavelength. Values of 6.4 +/- 0.1, 7.5 +/- 1.1, and 7.7 +/- 0.2 ns were obtained for the 6(2)D(3/2), 6(2)D(5/2), and 7(2)S(1/2) states, respectively, which agree with values obtained by previous authors, as well as calculated values. No current dependence was observed for each of these states. The lifetime of the long-lived thallium 6(2)P(3/2) degrees metastable state was measured by two-step laser-excited fluorescence at various applied currents. The metastable level was pumped by a 276.787 nm laser pulse, and a temporally delayed 535.046 nm laser pulse interrogated the population of the metastable state. Relating the fluorescence intensity to the population of the metastable state as a function of delay time yielded a decay curve for the 6(2)P(3/2) degrees metastable state. Values of 2.1 +/- 0.2, 2.8 +/- 0.1, 3.1 +/- 0.3, 3.8 +/- 0.4, and 4.8 +/- 0.6 micros were found for applied currents of 14.0, 12.0, 10.0, 8.0, and 6.0 mA, respectively. The resulting lifetimes for the 6(2)P(3/2) degrees metastable state clearly show a dependence on the applied current and are expected to be due to collisions with the wall of the cathode, as well as a contribution due to collisions with electrons.
Competing tunneling trajectories in a two-dimensional potential with variable topology as a model for quantum bifurcations (2003)

We present a path-integral approach to treat a two-dimensional model of a quantum bifurcation. The model potential has two equivalent minima separated by one or two saddle points, depending on the value of a continuous parameter. Tunneling is, therefore, realized either along one trajectory or along two equivalent paths. The zero-point fluctuations smear out the sharp transition between these two regimes and lead to a certain crossover behavior. When the two saddle points are inequivalent one can also have a first order transition related to the fact that one of the two trajectories becomes unstable. We illustrate these results by numerical investigations. Even though a specific model is investigated here, the approach is quite general and has potential applicability for various systems in physics and chemistry exhibiting multistability and tunneling phenomena.
DISCUSSION. ON PUBLIC WORKS IN THE BENGAL PRESIDENCY. (1858)

Keywords PUBLIC WORKS, RAILWAYS, CONSTRUCTION, EXPENDITURE, ROADS, CANALS, COSTS, ADMINISTRATION, RIVERS, EMBANKMENTS, NAVIGATION, STEAMERS, TUGS, INFRASTRUCTURE, COMMUNICATIONS, COUNTRIES, DEVELOPING, WATERWAYS, BUNDS, WORKS, INLAND, BOATS, SHIPS BENGAL INDIA, ASIA... Show All
The formation of protective coatings on tungsten-containing hard alloys by electrospark alloying with metals and borides (2011)

The electrospark alloying (ESA) of tungsten-containing hard alloys (THAs) with metals and borides is studied. A series of erosion resistance of borides is derived and a criterion for it is proposed. It is shown that electrode materials based on the borides are promising for coatings of hard alloys.
Treating hyperlipidemia, Part II: Making dietary control work in the elderly. (1987)

Changing lifestyle behaviors and eating habits are the most important recommendations a physician can make in controlling adverse lipid levels in the elderly. One may improve HDL cholesterol levels through encouraging smoking cessation, ideal weight maintenance, and aerobic exercise. This article discusses new dietary recommendations for lowering LDL cholesterol and provides a table of dietary tips for patients.
Comparability of narrow and wide field-of-view head-mounted displays for medium-field distance judgments (2012)

As wider field-of-view displays become more common, the question arises as to whether or not data collected on these displays are comparable to those collected with smaller field-of-view displays. This document describes a pilot study that aimed to address these concerns by comparing medium-field distance judgments in a 60° FOV display, a 150° FOV display, and a simulated 60° FOV within the 150° FOV display. The results indicate that participants performed similarly in both the actual and simulated 60° FOV displays. On average, participants in the 150° FOV display improved distance judgments by 13% over the 60° FOV displays.
Structural and multiferroic properties of La-modified BiFeO3 ceramics (2007)

The coexistence of the magnetic and the electrical properties in lanthanum (La)-modified bismuth ferrite (Bi1−xLaxFeO3, x=0.05, 0.1, 0.15, and 0.2) ceramics was studied and compared with those of bismuth ferrite (BiFeO3). The presence of a small secondary phase of BiFeO3 (arises due to excess Bi2O3) was removed on La substitution at the Bi site, as observed in x-ray diffraction (XRD). The effect of La substitution on dielectric constant, loss tangent, and remnant polarization of the samples was studied in a wide range of temperature (77–400K) and frequency (1kHz–1MHz). The variation of magnetization, coercive field, and exchange bias with temperature (2–300K) and La concentration were investigated. These changes in the magnetic parameters with La doping along with those of the electron magnetic resonance parameters measured at 300K and 9.28GHz are understood in terms of increase in the magnetic anisotropy and magnetization. These results also show that stabilization of crystal structure and nonuniformity in spin cycloid structure by La substitution enhances the multiferroic properties of BiFeO3.
Study of the ultrasonic ascertainment on the extent of creep damage in catalyst tubes (1980)

Equipment and method for an ultrasonic furnace test have been developed for routine inspection of catalytic reformer furnace tubes for creep damage. The ultrasonic method was selected after comparative testing of about 1000 HK40 tubes of a hydrocarbon/steam reformer by the ultrasonic furnace test, a radiographic furnace test, and a fluorescence test. The method, whose development and advantages are discussed, is ready for use although further development on removal of interference from surface roughness and metal structure is in progress.
NutriChip: nutrition analysis meets microfluidics (2012)

This focus article introduces the concept of NutriChip, an integrated microfluidic platform for investigating the potential of the immuno-modulatory function of dairy food. The core component of the NutriChip is a miniaturized artificial human gastrointestinal tract (GIT), which consists of a confluent layer of epithelial cells separated from a co-culture of immune cells by a permeable membrane. This setting creates conditions mimicking the human GIT and allows studying processes that characterize the passage of nutrients though the human GIT, including the activation of immune cells in response to the transfer of nutrients across the epithelial layer. The NutriChip project started by developing a biologically active in vitro cellular system in a commercial Transwell co-culture system. This Transwell system serves as a reference for the micro-scale device which is being developed. The microfluidic setup of NutriChip allows monitoring of the response of immune cells to pro-inflammatory stimuli, such as lipid polysaccharide (LPS), and to the application of potentially anti-inflammatory dairy food. This differential response will be quantified by measuring the variation in expression of pro-inflammatory cytokines, including interleukin 1 (IL-1) and interleukin 6 (IL-6), secreted by the immune cells, and this is achieved by using a dedicated optical imager. A series of dairy products will be screened for their anti-inflammatory properties using the NutriChip system and, finally, the outcome of the NutriChip will be validated by a human nutrition trial. Therefore, the NutriChip platform offers a new option to evaluate the influence of food quality on health, by monitoring the expression of relevant immune cell biomarkers.
ASSESSMENT OF OXIDATION IN HEATED SAFFLOWER OIL BY PHYSICAL, CHEMICAL AND SPECTROSCOPIC METHODS (1998)

ABSTRACT Safflower oil was heated at 180C by static heating in an open pan or in an oven, or by heating through intermittent heating‐cooling cycles (as in frying) over a period of 8 h. The extent of deterioration of the oil was followed by measurement of physical characteristics such as color and viscosity and the chemical indices such as free fatty acid, peroxide, iodine, conjugated diene and triene values, unsaponifiable matter and oxidized fatty acids. The extent of oxidation was also assessed by infrared (IR) and nuclear magnetic resonance (NMR) spectroscopic techniques through analysis of oxidized fatty acids. The results indicated that heating in open pan caused deterioration in oil faster than in other treatments. Furthermore, the IR, and NMR studies of the oil heated in an open pan indicated cross polymerization while during oven heating and frying cross polymerization was not observed.
HyDRA: gene prioritization via hybrid distance-score rank aggregation (2014)

Supplementary data are available at Bioinformatics online.
Boosting Face Recognition in Real-World Surveillance Videos (2012)

Face recognition becomes a challenging problem in real-world surveillance videos where the low-resolution probe frames exhibit variations in pose, lighting condition, and facial expressions. This is in contrast with the gallery images which are generally frontal view faces acquired under controlled environments. A direct matching of probe images with gallery data often leads to poor recognition accuracy due to the significant discrepancy between the two kinds of data. In addition, the artifacts such as low resolution, blurriness and noise further enlarge this discrepancy. In this paper, we propose a video based face recognition framework using a novel image representation called warped average face (WAF). The WAFs are generated in two stages: in-sequence warping and frontal view warping. The WAFs can be easily used with various feature descriptors or classifiers. As compared to the original probe data, the image quality of the WAFs is significantly better and the appearance difference between the WAFs and the gallery data is suppressed. Given a probe sequence, only a few WAFs need to be generated for the recognition purpose. We test the proposed method on the ChokePoint dataset and our in-house dataset of surveillance quality. Experiments show that with the new image representation, the recognition accuracy can be boosted significantly.
Pass-transistor dual value logic for low-power CMOS (2002)

This paper presents new pass-transistor logic termed DVL which contains fewer transistors than its counterpart DPL yet maintaining comparable performance. A method for synthesis of such networks is also developed and demonstrated in this paper. The new logic is characterized by good speed and low power. The simulations and tests were performed using 1-/spl mu/m CMOS.
The Preparation of N,N-Difluorosulfamide (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of N,N-DifluorosulfamideRobert A. Wiesboeck and J. K. RuffCite this: Inorg. Chem. 1965, 4, 1, 123–125Publication Date (Print):January 1, 1965Publication History Published online1 May 2002Published inissue 1 January 1965https://pubs.acs.org/doi/10.1021/ic50023a033https://doi.org/10.1021/ic50023a033research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On a sheath between a plasma and a conducting surface (2004)

The influence of plasma inertia and temperature and wall polarity on the formation of a stationary charged sheath between the plasma and a conducting wall was considered. A criterion for stationary sheath existence for both negative and positive wall polarities was formulated and applied to several special cases. It was shown, in particular, that a sheath is not formed in a two-beam plasma with cold electrons and cold or warm supersonic ions. The formation of a discontinuity-like a shock wave at a thermal singularity was analyzed. Consideration of special cases showed that conditions for the steady sheath are compatible with the condition for shock wave formation (supersonic ions) only in the case of positive wall potential, hot electrons and warm ions, moving to the wall with velocity greater then the ion-sound velocity. The determined maximum wall positive potential at which no discontinuity forms is φc=[ZTe−Ti ln(1+(ZTe/Ti))]/2Ze, where Te is the electron temperature, and Ti and Ze are the ion temperature and charge.
More Is Not Necessarily Easier (2001)

In this brief comment, we consider the exact, deterministic, and nonasymptotic transformation of multiple copies of pure states under LOCC. It was conjectured in quant-ph/0103131 that, if $k$ copies of $|ψ\>$ can be transformed to $k$ copies of $|ϕ\>$, the same holds for all $r \geq k$. We present counterexamples to the above conjecture.
(<i>E</i>)-1-Benzyl-3-(2-nitrovinyl)-1<i>H</i>-indole (2006)

In the title mol­ecule, C17H14N2O2, the indole ring system is essentially planar and makes a dihedral angle of 87.93 (3)° with the plane of the benzene ring. The nitro­vinyl double bond adopts the E geometry.
Altered Basement Membrane Synthesis in the Testis After Tissue Injury (1998)

The basement membrane plays an important role in maintaining the structural and functional integrity of tissues. Altered basement membrane structure has been associated with severe functional impairment of the testis in several conditions, including vasectomy, autoimmune orchitis, cryptorchidism, and following x-irradiation. We have used efferent duct ligation as a model to examine seminiferous tubular basement membrane morphology, synthesis, and gene expression to determine whether altered basement membrane synthesis is responsible for the aberrant structures noted after tissue injury. On days 2 and 3 after ligation, both the seminiferous epithelium and the basement membrane appeared normal, but 7 days after ligation, the seminiferous epithelium began to degenerate. The basement membrane appeared detached from the epithelium, and redundant patches of basement membrane were observed adjacent to the Sertoli cells at 14 and 21 days postligation. Immunoprecipitation indicated an increase in laminin protein synthesis in the ligated tubules at the same time. Northern blot analysis showed increases in transcript levels for laminin as well as collagen IV and heparan sulfate proteoglycan. These data show that new protein synthesis is responsible, at least in part, for the duplication of the basement membrane coincident with the tissue damage caused by efferent duct ligation.
Abstract 182: Novel hydroxamic acid-derivative, MHY218, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells (2011)

Abstract In this study, we investigated the anti-proliferative and pro-apoptotic properties of novel hydroxamic acid-derivative, MHY218, in HCT116 human colon cancer cells. We found that treatment of cells with MHY218 resulted in growth inhibition and induction of apoptosis in a concentration-dependent manner. The induction of apoptosis was showed by decreased viability, cleavage of poly(ADP-ribose) polymerase (PARP), alteration in the ratio of Bax/Bcl-2 protein expression, and activation of caspase-8 and -9 together with caspase-3. In addition, MHY218 induced G2/M phase cell cycle arrest which was related to a decrease in the protein expression of cyclin B1 and its activating partners Cdc25c and Cdc2. MHY218 also caused an increase in the expression levels of p21WAF1/CIP1 in a p53-independent pathway. Nuclear transcription factor-kappa B (NF-κB) has been reported to be an implicated factor in apoptotic cell death of various cancer cells. Therefore, we found the effect of MHY218 on NF-κB signaling pathway. Treatment of cells with MHY218 resulted in inhibition of the expression levels of NF-κB and IκBα in a dose-dependent manner. These results suggest that MHY218 may have potential as a chemotherapeutic agent for prevention against colon cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 182. doi:10.1158/1538-7445.AM2011-182
La dysplasie cléido-crânienne : attitudes thérapeutiques et recommandations. À propos d'une observation clinique (2009)

La dysplasie cléido-crânienne est une maladie génétique rare, aux formes d'expressions étonnamment variables. Elle se manifeste principalement par des anomalies squelettiques, claviculaires, et cranio-faciales nombreuses et évolutives. Parmi elles, les signes dentaires restent encore souvent à l'origine du diagnostic et se révèlent parmi les plus handicapants pour les patients. Ainsi, à l'adolescence, la démarche thérapeutique s'axe presque exclusivement sur la sphère oro-faciale et mobilise l'ensemble des disciplines odontologiques. Aujourd'hui, les stratégies thérapeutiques tiennent compte des mécanismes physiopathologiques de l'affection et aboutissent à des résultats satisfaisants justifiant de longues périodes de traitement. Une observation clinique illustre notre propos.
Endoilluminated infusion cannula for anterior segment surgery (2012)

The author has no financial or proprietary interest in any material or method mentioned.
Beneath the Surface (2019)

<p class="MsoNormal" style="line-height:normal">My research findings from investigating methods to create color and imagery with plants on textiles inform applications for textile design. Coreopsis plants were pounded on jersey knit to create imagery and also used as the dyestuff along with chestnut. Reminiscent of the thermal and decorative quilted petticoat, fabrics were layered and free-motion stitched for thermal comfort with the plant imagery was revealed through reverse applique. The surface design conceptually portrays what is beneath the surface of winter's frozen ground as well as the research behind the coloration methods.
Rate coefficient for H + CH4 → H2 + CH3 in the temperature range 1300–1700 °K (1974)

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ChemInform Abstract: Synthesis of 1,4‐Dihydro‐4‐oxopyridazino(1,6‐a)indole‐3‐carboxylic Acids and 1,4‐Dihydro‐4‐oxopyrido(3′,2′:4,5)pyrrolo(1,2‐b)pyridazine‐3‐ carboxylic Acids as Potential Antibacterial Agents. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.