gebhart/patrepeval huggingface dataset:
Abstract 4921: Selective promoter methylation of the cell differentiation marker, intestinal alkaline phosphatase (iALP), in microsatellite unstable colon cancer (2010)

Abstract Tumorigenesis is characterized by excessive cell growth, resistance to apoptosis and aberrant cellular differentiation. In particular, MSI colorectal cancer is frequently characterized by poorly differentiated histology. Histone Deacetylase inhibitors (HDACi) are a novel class of cancer therapeutics that induce growth arrest, apoptosis and differentiation of a variety of tumour types, including colon cancer cells. Differentiation inducing agents have been used effectively to treat hematopoietic malignancies, prompting us to examine the effects of HDACi treatment on differentiation of colon cancer cells, and to compare the effects induced in MSS and MSI colon cancers. Remarkably, while HDACi treatment robustly and consistently induced differentiation induction as measured by alkaline phosphatise activity and iALP gene expression in multiple MSS colon cancer cell lines, approximately 70% of MSI colon cancer cell lines were highly resistant to HDACi-induced ALP induction. Examination of the coding sequence of the iALP gene failed to identify any significant repeat elements suggesting mutation is unlikely to be responsible for lack of iALP induction. Furthermore, transient transfection of an iALP promoter reporter construct demonstrated robust induction in response to butyrate treatment in both MSS and MSI lines, suggesting loss of a key regulatory factor in MSI cell lines is not likely to be responsible. Conversely, examination of iALP promoter methylation by bisulphite conversion and direct sequencing demonstrated multiple CpG sites, including a Sp1/Sp3 binding site, to be methylated in 4 of 5 MSI lines examined, while no methylation was observed in MSS lines. These findings were confirmed using the sequenom assay. ALP promoter methylation was independent of CIMP status. The importance of Sp1/Sp3 in butyrate-induced iALP induction was demonstrated by the ability of the Sp1/Sp3 inhibitor, mithramycin, to attenuate butyrate-induced ALP activity. Finally, consistent with methylation being a key determinant of iALP expression in MSI lines, azacytidine treatment was able to re-induce iALP expression, and butyrate-induction of ALP expression was markedly enhanced in isogenic HCT116 cells lacking the DNA methyltransferases Dnmt1 and Dnmt3b (DKO), compared to parental cells. These findings demonstrate selective promoter methylation of iALP in MSI colon cancer cell lines. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4921.
ChemInform Abstract: A Novel Reaction for the Functionalization of Epoxy Resins: New Regio‐and Chemoselective Ring‐Opening of Epoxides with Aryl Silyl Ethers Catalyzed by Cesium Fluoride. (1990)

Abstract Phenyl glycidyl ether (I) reacts with phenyl trimethylsilyl ether (II) in the presence of cesium fluoride to form the glycerol trisether (III) which is hydrolyzed and oxidized, yielding the keto bisether (IV).
Effect of developer temperature and normality on chemically amplified photoresist dissolution (1999)

The effects of developer temperature and developer normality on the dissolution behavior of a 248nm chemically amplified resist are examined using development rate measurements. Using a RDA-790 development rate measurement tool employing a 470nm Blue LED measurement wavelength, dissolution rats as a function of dose and depth into the resist were measured. Each data set was analyzed and the performance of rate versus t-BOC concentration was fit to appropriate models. The variation of these results with developer temperature has led to further temperature-dependent characterization of the dissolution modeling parameters. The variation of dissolution rate with developer normality has led to an initial characterization of the normality-dependent dissolution modeling parameters. The maximum dissolution rate R<SUB>max</SUB> is shown to exhibit two regions of Arrhenius behavior with a well defined activation energy for both. The dissolution selectivity parameter n proves to have a more complicated behavior.
Improving superscalar instruction dispatch and issue by exploiting dynamic code sequences (1997)

Superscalar processors currently have the potential to fetch multiple basic blocks per cycle by employing one of several recently proposed instruction fetch mechanisms. However, this increased fetch bandwidth cannot be exploited unless pipeline stages further downstream correspondingly improve. In particular, register renaming a large number of instructions per cycle is difficult. A large instruction window, needed to receive multiple basic blocks per cycle, will slow down dependence resolution and instruction issue. This paper addresses these and related issues by proposing (i) partitioning of the instruction window into multiple blocks, each holding a dynamic code sequence; (ii) logical partitioning of the register file into a global file and several local files, the latter holding registers local to a dynamic code sequence; (iii) the dynamic recording and reuse of register renaming information for registers local to a dynamic code sequence. Performance studies show these mechanisms improve performance over traditional superscalar processors by factors ranging from 1.5 to a little over 3 for the SPEC Integer programs. Next, it is observed that several of the loops in the benchmarks display vector-like behavior during execution, even if the static loop bodies are likely complex for compile-time vectorization. A dynamic loop vectorization mechanism that builds on top of the above mechanisms is briefly outlined. The mechanism vectorizes up to 60% of the dynamic instructions for some programs, albeit the average number of iterations per loop is quite small.
ChemInform Abstract: N′‐[4‐[(Substituted imino)methyl]benzylidene]‐substituted Benzohydrazides: Synthesis, Antimicrobial, Antiviral, and Anticancer Evaluation, and QSAR Studies. (2013)

Abstract Extensive QSAR studies of newly synthesized title compounds reveal that (VIIIa) and (VIIIb) are the most potent antimicrobial agents.
Modulation of cisplatin activity and toxicity: changing the drug or changing the target. (1993)

Cisplatin (CDDP) is an effective chemotherapeutica gent for the treatment of a variety of human cancers. Drug toxicity and resisLancea re the lirnitations to its application in clinical practice. In this thesis a number of strategies to overcome these problems are investigated. Zie: Summary and conclusions
Effects of Tetrathiomolybdate in a Mouse Model of Retinal Neovascularization (2004)

TM significantly inhibits retinal neovascularization and VEGF production in a mouse model of retinal neovascularization.
Electronic Structure of Methoxy-, Bromo-, and Nitrobenzene Grafted onto Si(111) (2006)

The properties of Si(111) surfaces grafted with benzene derivatives were investigated using ultraviolet photoemission spectroscopy (UPS) and X-ray photoelectron spectroscopy (XPS). The investigated materials were nitro-, bromo-, and methoxybenzene layers (-C(6)H(4)-X, with X = NO(2), Br, O-CH(3)) deposited from diazonium salt solutions in a potentiostatic electrochemical process. The UPS spectra of the valence band region are governed by the molecular orbital density of states of the adsorbates, which is modified from the isolated state in the gas phase due to molecule-molecule and molecule-substrate interaction. Depending on the adsorbate, clearly different emission features are observed. The analysis of XPS intensities clearly proves multilayer formation for bromo- and nitrobenzene in agreement with the amount of charge transferred during the grafting process. Methoxybenzene forms only a sub-monolayer coverage. The detailed analysis of binding energy shifts of the XPS emissions for determining the band bending and the secondary electron onset in UPS spectra for determining the work function allow one to discriminate between surface dipole layers--changing the electron affinity--and band bending, affecting only the work function. Thus, complete energy band diagrams of the grafted Si(111) surfaces can be constructed. It was found that silicon surface engineering can be accomplished by the electrochemical grafting process using nitrobenzene and bromobenzene: silicon-derived interface gap states are chemically passivated, and the adsorbate-related surface dipole effects an increase of the electron affinity.
The role of optometry in collaborative eye care (2016)

In 2010, Vision 2020 in conjunction with Access Economics published a report outlining the worrying trend of loss of vision in Australia.2010 The predicted number of Australians over 40-years of ag...
Ion-Assisted Nucleation in Amorphous Silicon: Ion Mass and Dose Rate Effects (1991)

The nucleation of crystal grains in amorphous silicon induced by 600 keV Kr or Ar irradiation is investigated. It is shown that at 500 °C the nucleation rate is greatly enhanced with respect to the pure thermal value. An unexpected behaviour is observed by changing ion mass and/or dose rate in contrast with the trend measured for the growth rate. An increase in dose rate results in a decrease in the nucleation rate without any appreciable variation of the growth velocity. These data, that are successfully described by classical models of nucleation and growth, are discussed and qualitatively explained by assuming that beam-generated defects modify the free-energy content of both amorphous and crystalline phases.
Totally synthetic heme protein models based on complexes with superstructure ligands (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotally synthetic heme protein models based on complexes with superstructure ligandsWayne P. Schammel, Kristin S. B. Mertes, Gary G. Christoph, and Daryle H. BuschCite this: J. Am. Chem. Soc. 1979, 101, 6, 1622–1623Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/ja00500a057https://doi.org/10.1021/ja00500a057research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IGFs and Binding Proteins in Short Children with Intrauterine Growth Retardation (2002)

The aim of this study was to examine the relationship between the IGF-IGF binding protein (IGFBP) axis and insulin secretion in short intrauterine growth retardation (IUGR) children. Fifteen IUGR and 12 normal short prepubertal subjects had a 90-min frequently sampled iv glucose tolerance test performed to measure plasma glucose, insulin, IGF-I, IGF-II, IGFBP-3, and IGFBP-1. In addition, 29 nonobese prepubertal subjects of normal height had fasting plasma IGF-I and IGFBP-3 levels measured. In comparison to short normal subjects, IUGR subjects had higher plasma values for IGF-I (42 +/- 10 vs. 77 +/- 31 microg/liter; P < 0.0001), IGF-II (291 +/- 76 vs. 370 +/- 66 microg/liter; P < 0.008), IGFBP-3 (1.66 +/- 0.28 vs. 2.07 +/- 0.48 mg/liter; P < 0.0005), fasting insulin (2 +/- 1 vs. 4 +/- 2 mU/liter; P < 0.004), and acute insulin response (AIR; 215 +/- 36 vs. 504 +/- 90 mU/liter; P = 0.008). Nonobese subjects of normal height had higher plasma IGF-I (117 +/- 9 microg/liter; P < 0.0001) and IGFBP-3 (2.34 +/- 0.12 mg/liter) values than the IUGR group (P < 0.0005). During the frequently sampled iv glucose tolerance test, the magnitude of the AIR in short normal subjects was related to the fall in IGFBP-1 levels (P = 0.03); however, no relationship was seen between AIR and fall in IGFBP-1 in IUGR subjects (P = 0.24). In conclusion, short IUGR children have higher plasma IGF-I, IGF-II, and IGFBP-3, when compared with normal children matched for height, weight, and pubertal status. We speculate that hyperinsulinism secondary to insulin resistance may have led to these changes to the IGF-IGFBP axis in the IUGR group.
Verification and validation of physiology simulators (2015)

In this paper we describe a general method to provide verification and validation of physiological simulators. We also present an application of this method and key results.
Peripheral Blood Leukocyte Gene Expression Patterns and Metabolic Parameters in Habitually Snoring and Non-Snoring Children with Normal Polysomnographic Findings (2011)

PS children do not exhibit global perturbations in their PBL transcriptional response, suggesting that current normative PSG criteria are overall valid. However, subtle differences in functionally coherent pathways involved in glycemic homeostasis were detected and confirmed in a larger independent pediatric cohort indicating that PS may carry increased risk for end-organ morbidity in susceptible children.
Calculations of the electron-energy-loss spectra of silicon nanostructures and porous silicon (1997)

The electronic excitations in quantum-size silicon molecules, wires, or spheres are investigated by the evaluation of the full frequency-dependent dielectric matrix of the system. The calculation is based on a tight-binding framework in the random-phase approximation. The energy-loss spectra derived for fast electrons interacting with the nanostructures are dominated by collective excitations corresponding to bulk and surface modes even for nanostructures containing a small number of atoms. In contrast to the static screening, the dynamical properties are not strongly affected by the quantum confinement and are well described by the classical theories. We show that these collective modes are only slightly sensitive to surface defects and that low-energy excitations below 8 eV are only observable for one-dimensional silicon molecules, e.g., for polysilanes. These results are used to discuss the recent experimental observations made on fresh and oxidized porous silicon.
Fluxional Isomerism in a Prebullvalene Lactone (1970)

Abstract A prebullvalene lactone exhibits fluxional isomerism in solution. Analysis of proton NMR. spectra at 100 MHz and 220 MHz together with variable temperature studies show that the species existing in solution are 7, 8 and 9 .
Atmospheric turbulence and the resolution limits of large ground-based telescopes: comment (1993)

The paper by McKechnie [ J. Opt. Soc. Am. A9, 1937 ( 1992)] is discussed, in which McKechnie tries to explain astronomers’ visual descriptions of bright cores in star images by using his own model of atmospheric inhomogeneities, which is different from the conventional turbulent model. In this Communication we show that the star images presented by McKechnie are consistent with the traditional turbulent model. The McKechnie model of scattering, a single-scale atmosphere with the characteristic scale L0 ≃ 35 cm, contradicts all our experiences with turbulence: both direct in situ measurements of turbulent characteristics and indirect experiments of wave propagation in a turbulent atmosphere.
Stereoselective Synthesis of the Conformationally Constrained Glutamate Analogue, (-)-(2<i>R</i>,3<i>S</i>)-<i>cis</i>-2-Carboxyazetidine-3-acetic Acid, from (<i>S</i>)-<i>N</i>-Tosyl-2-phenylglycine (2005)

Made available in DSpace on 2014-07-31T14:15:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2005
Measurement of the Higgs boson mass from the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>H</mml:mi><mml:mo stretchy="false">→</mml:mo><mml:mi>γ</mml:mi><mml:mi>γ</mml:mi></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi>H</mml:mi><mml:mo stretchy="false">→</mml:mo><mml:mi>Z</mml:mi><mml:msup><mml:mrow><mml:mi>Z</mml:mi></mml:mrow><mml:mrow><mml:mo>*</mml:mo></mml:mrow></mml:msup><mml:mo stretchy="false">→</mml:mo><mml:mn>4</mml:mn><mml:mo>ℓ</mml:mo></mml:mrow></mml:math>channels in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>p</mml:mi><mml:mi>p</mml:mi></mml:math>collisions at center-of-mass energies of 7 and 8 TeV with the ATLAS detector (2014)

An improved measurement of the mass of the Higgs boson is derived from a combined fit to the reconstructed invariant mass spectra of the decay channels H and H ZZ 4l. The analysis uses the pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at center-of-mass energies of 7 TeV and 8 TeV, corresponding to an integrated luminosity of 25 fb -1 . The measured value of the Higgs boson mass is m H 125.36 AE 0.37stat AE 0.18syst GeV. This result is based on improved energy-scale calibrations for photons, electrons, and muons as well as other analysis improvements, and supersedes the previous result from ATLAS. Upper limits on the total width of the Higgs boson are derived from fits to the invariant mass spectra of the H and H ZZ 4l decay channels.
Perspective envelopes for bilinear functions (2019)

We characterize the convex hull of the set defined by a bilinear function f (x, y) = xy and a linear inequality linking x and y. The new characterization, based on perspective functions, dominates the standard McCormick convexification approach. In practice, this result can be of great value in global optimization frameworks, helping to tighten the bounds provided by convex relaxations. The new formulation has the potential to improve the pruning process in spatial branch and bound schemes and consequently reduce the search space effort.
Déficit neural en IGF-1: generación y caracterización de nuevos modelos celulares (2019)

Trabajo presentado en la XII Reunion Anual del CIBER de Enfermedades Raras, celebrada en San Lorenzo del Escorial (Espana) del 12 al 14 de marzo de 2019.
Heterofunctional Ligands Derived from Monooxidized Bis(phosphino)amines. Synthesis and Transition Metal (Rh(I), Pd(II), Pt(II)) Complexes of the Triphosphorus Ligands ((Iminophosphoranyl)amino)phosphine Phosphinic Oxides Ph2PN(R)Ph2P:NP(O)(OPh)2 (R = CH3, C2H5). Crystal and Molecular Structures of the Rhodium(I) and Platinum(II) Complexes (PhO)2(O)PN:PPh2N(C2H5)Ph2PRh(CO)Cl and (PhO)2(O)PN:PPh2N(C2H5)Ph2PPtCl2 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeterofunctional Ligands Derived from Monooxidized Bis(phosphino)amines. Synthesis and Transition Metal (Rh(I), Pd(II), Pt(II)) Complexes of the Triphosphorus Ligands ((Iminophosphoranyl)amino)phosphine Phosphinic Oxides Ph2PN(R)Ph2P:NP(O)(OPh)2 (R = CH3, C2H5). Crystal and Molecular Structures of the Rhodium(I) and Platinum(II) Complexes (PhO)2(O)PN:PPh2N(C2H5)Ph2PRh(CO)Cl and (PhO)2(O)PN:PPh2N(C2H5)Ph2PPtCl2Maravanji S. Balakrishna, Bernard D. Santarsiero, and Ronald G. CavellCite this: Inorg. Chem. 1994, 33, 14, 3079–3084Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://doi.org/10.1021/ic00092a011RIGHTS & PERMISSIONSArticle Views201Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (752 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Benzamides, p‐nitrobenzamides, benzenesulfonamides,<i>p</i>‐toluene‐sulfonamides, and acetamides as identification derivatives of long‐chain amines (1957)

Summary Benzamides, p‐nitrobenzamides, benzenesulfonamides, p ‐toluenesulfonamides, p‐nitrobenzenesulfonamides, and acetamides of dodecyl, tetradecyl, hexadecyl, and octadecyl amines were synthesized and evaluated as identification derivatives. Acetamides melt approximately 7° apart and the benzene sulfonamides approximately 6° apart. Seventeen previously unreported compounds were prepared.
What to do before you nuke your multiple hearth furnace: Practical tips and techniques for improving operation, reducing emissions and meeting the regulations (1993)

The paper emphasizes several approaches for improving the operation of multiple hearth sludge incinerators. First, it is highly recommended that auxiliary fuel be added above the combustion hearth, to the maximum practical extent. Secondly, means should be provided to increase gas-phase mixing and turbulence within each hearth, to minimize the formation of localized oxygen-starved regions (pyrolysis pathways) and reduce the kinetic limitations on the destruction of volatile organics and products of incomplete combustion. One should also consider means to improve wet scrubbing system performance, as it complements the combustion process in controlling a variety of related emissions.
Angular diameter measurements of stars (1991)

Angular diameters determined with the Mark III Optical Interferometer are presented for 12 stars at wavelengths of 450 and 800 nm. The uniform disk diameters resulting from fits to the visibility observations have rms residuals of order 1 percent for the 800 nm measurements and less than 3 percent for the 450 nm measurements. The improvement over previous observations with this instrument is due to improved data analysis and the use of a wider range of baseline lengths. An analysis of the calibration systematics for the Mark III Optical Interferometer is included. There is good agreement between these measurements and previously published data. The changes in uniform disk diameter between wavelengths of 450 and 800 nm agree with models of stellar atmospheres.
Isotope effects in dense solid hydrogen: Phase transition in deuterium at 190±20 GPa (1989)

Raman measurements of solid normal deuterium compressed in a diamond-anvil cell indicate that the material undergoes a structural phase transformation at 190\ifmmode\pm\else\textpm\fi{}20 GPa and 77 K. Spectroscopically, the transition appears analogous to that observed in hydrogen at 145\ifmmode\pm\else\textpm\fi{}5 GPa. The large isotope effect on the transition pressure suggests there is a significant vibrational contribution to the relative stability of the solid phases of hydrogen at very high densities.
Growth inhibition in the skin induced by parenteral administration of adrenocorticotropin (1948)

No Abstract.