gebhart/patrepeval huggingface dataset:
Operational control of item flow in versatile manufacturing systems (1979)

Analyses of operational control of item flow in versatile manufacturing systems, including control of part-type and mix-ratio, process selection, part entry, and part-to-machine allocation, show significant effects on performance. General principles of operational flow control are indicated.
Mammary Development and Milk Yield in Relation to Growth Rate in Dairy and Dual-purpose Heifers (1978)

(1978). Mammary Development and Milk Yield in Relation to Growth Rate in Dairy and Dual-purpose Heifers. Acta Agriculturae Scandinavica: Vol. 28, No. 1, pp. 41-46.
Sevoflurane-induced changes of field potential activity are detected by Benfords Law (2006)

1Department of Anesthesiology, Technische Universitaet Muenchen, Klinikum Rechts der Isar, Germany; 2Department of Anesthesiology, Section of Experimental Anesthesiology, University of Tuebin
Pulmonary nocardiosis during immunosuppressive therapy for idiopathic pulmonary fibrosis (2000)

Nocardiosis is a subacute or chronic suppurative infection caused by Nocardia species. Although it is more common in immunocompromised hosts, idiopathic pulmonary fibrosis (IPF) has not been recognized as a predisposing factor for nocardial infection. We report a case of IPF, in which pulmonary nocardiosis developed during treatment with prednisolone and cyclophosphamide. The risk of pulmonary nocardiosis may be increased in cases of IPF on immunosuppressive therapy. Since IPF often accompanies lung carcinoma, it is important to correctly differentiate nocardiosis from carcinoma.
Lipase‐catalyzed esterification of cinnamic acid and oleyl alcohol in organic solvent media (2005)

Abstract The esterification of cinnamic acid (CA) and oleyl alcohol (OA) in organic solvent media by immobilized lipase Novozym 435 was optimized in terms of selected parameters, including the logarithm of the 1‐octanol/water partition coefficient of the organic solvent (log P , 0.29–4.5), initial water activity ( a w , 0.05–0.75), agitation speed (0–200 rpm), temperature (35–65 °C) and ratio of substrates (CA/OA, 1.0:0.5–1.0:6.0). The results showed that the more hydrophobic solvent mixtures and lower initial a w values resulted in a higher enzymatic activity and bioconversion yield. The most appropriate solvent medium and initial a w value was the mixture of iso‐octane/2‐butanone (85:15, v/v) and 0.05, respectively. The results also showed that an agitation speed of 150 rpm and a reaction temperature of 55 °C were optimal for the reaction system. The activation energy ( E a ) of the esterification reaction was calculated as 43.6 kJ mol −1 . The optimal ratio of CA to OA was 1.0:6.0, with the absence of any inhibition by OA. Using the optimized conditions, the maximum enzymatic activity was 390.3 nmol g −1 min −1 , with a bioconversion yield of 100% after 12 days of reaction. In addition, the electrospray ionization‐mass spectroscopy analysis confirmed that the major end product of the esterification reaction was oleyl cinnamate. Copyright © 2005 Society of Chemical Industry
PARTIAL CHARACTERIZATION OF TWO APHID-TRANSMITTED VIRUSES ASSOCIATED WITH YELLOW LEAFSPOT OF SPIRAEA (2002)

Two previously undescribed viruses were associated with a yellow leafspot disease of spiraea (Spiraea spp.) in the midwestern USA. The first virus, named spiraea leafspot virus (SLSV) is a badnavirus which has a 7.4 kb dsDNA genome and resembles other badnaviruses in particle and genome properties, but is unusual in being transmitted by an aphid (Aphis spiraecola) rather than by mealybugs. The second virus, which is also transmitted by A. spiraecola, has spherical 30-35 nm particles containing a 7.2 kb ds RNA genome. This virus was named spiraea leafspot spherical virus (SLSSV). In particle morphology and genome type SLSSV resembles some members of the family Totiviridae, none of which have been reported to infect plants or higher organisms. In the majority of cases SLSV and SLSSV occurred in mixed infections. Early-season symptoms were associated with the presence of SLSSV and absence of SLSV, whereas late-season symptoms were associated with the presence of SLSV and absence or greatly reduced levels of SLSSV.
A noniterative greedy algorithm for multiframe point correspondence (2004)

This paper presents a framework for finding point correspondences in monocular image sequences over multiple frames. The general problem of multiframe point correspondence is NP-hard for three or more frames. A polynomial time algorithm for a restriction of this problem is presented and is used as the basis of the proposed greedy algorithm for the general problem. The greedy nature of the proposed algorithm allows it to be used in real-time systems for tracking and surveillance, etc. In addition, the proposed algorithm deals with the problems of occlusion, missed detections, and false positives by using a single noniterative greedy optimization scheme and, hence, reduces the complexity of the overall algorithm as compared to most existing approaches where multiple heuristics are used for the same purpose. While most greedy algorithms for point tracking do not allow for entry and exit of the points from the scene, this is not a limitation for the proposed algorithm. Experiments with real and synthetic data over a wide range of scenarios and system parameters are presented to validate the claims about the performance of the proposed algorithm.
Analysis of the interacting surface of maurotoxin with the voltage‐gated <i>Shaker</i> B K<sup>+</sup> channel (2011)

Maurotoxin (MTX) is a 34-residue toxin that was isolated initially from the venom of the scorpion Scorpio maurus palmatus. Unlike the other toxins of the α-KTx6 family (Pi1, Pi4, Pi7, and HsTx1), MTX exhibits a unique disulfide bridge organization of the type C(1) C(5) , C(2) C(6) , C(3) C(4) , and C(7) C(8) (instead of the conventional C(1) C(5) , C(2) C(6) , C(3) C(7) , and C(4) C(8) , herein referred to as Pi1-like) that does not prevent its folding along the classic α/β scaffold of scorpion toxins. MTX(Pi1) is an MTX variant with a conventional pattern of disulfide bridging without any primary structure alteration of the toxin. Here, using MTX and/or MTX(Pi1) as models, we investigated how the type of folding influences toxin recognition of the Shaker B potassium channel. Amino acid residues of MTX that were studied for Shaker B recognition were selected on the basis of their homologous position in charybdotoxin, a three disulfide-bridged scorpion toxin also active on this channel type. These residues favored either an MTX- or MTX(Pi1) -like folding. Our data indicate clearly that Lys(23) and Tyr(32) (two out of ten amino acid residues studied) are the most important residues for Shaker B channel blockage by MTX. For activity on SKCa channels, the same amino acid residues also affect, directly or indirectly, the recognition of SK channels. The molecular modeling technique and computed docking indicate the existence of a correlation between the half cystine pairings of the mutated analogs and their activity on the Shaker B K(+) channel. Overall, mutations in MTX could, or could not, change the reorganization of disulfide bridges of this molecule without affecting its α/β scaffold. However, changing of the peptide backbone (cross linking disulfide bridges from MTX-like type vs MTX(Pi1) -like type) appears to have less impact on the molecule activity than mutation of certain key amino acids such as Lys(23) and Tyr(32) in this toxin.
Simple Model for the Capacity of Amorphous Silicon-Aluminum-Transition Metal Negative Electrode Materials (2006)

Thin-film libraries of (M=Cr, Fe, Mn, Ni) negative electrode materials were characterized using combinatorial and high-throughput techniques. Transition metal content had a large effect on capacity, such that alloys with more than ca. did not alloy with Li during room temperature or charge-discharge cycling. The contour line was used to separate those compositions that readily alloyed with Li from those that did not. This contour line also approximately connects the lowest content equilibrium crystalline phases. We propose that all crystalline equilibrium phases are inactive. The capacity of a given composition of can be approximated, to first order, using only the equilibrium ternary phase diagram. These results could have a large impact on the study of other, more complex, amorphous alloy negative electrode material systems.
Anatomic genomics: Systems of genes supporting the biology of systems (2000)

This essay lays the groundwork for the concept that “anatomy” in the new millennium will be a subject that is increasingly based on understanding the parallel relationships between systems of genes on chromosomes and the structures defined by these genes. The concept of Anatomic Genomics is introduced in terms of systems of genes on chromosomes, which actually mirror the biology of anatomically defined systems. A case is made for the possibility that genomes may be structured in ways that make local but not necessarily global sense. In the new millennium, systems biologists have the opportunity to be the creators and purveyors of this new anatomy. Anat Rec 259:1–2, 2000. © 2000 Wiley-Liss, Inc.
Recovery and Cultivation of Keratinocytes From Shipped Mouse Skin (2014)

Murine keratinocyte culture from neonatal skin is an important tool for studying the functional role of specific genes in epithelial biology. However, when the transgenic animal is only available in a geographically distant local, obtaining viable keratinocytes can be problematic. A method for transferring the isolated murine skin from collaborating labs could decrease the cost of shipping live animals, and would allow the efficient use of the tissues from the transgenic animals. Here we optimized shipping conditions and characterized the cells retrieved and cultured from mouse skin shipped for 48 h at 0 °C. The cultured keratinocytes from the control, non-shipped skin and the 2-day shipped skin were 43.6 +/- 7.8% viable, doubled every 2 days, and expressed comparable amounts of heat shock proteins and CD29/integrin beta-1. However, under the same shipping conditions, the 3-day shipped tissue failed to establish colonies in the culture. Therefore, this 2-day shipping technique allows the transfer mouse skin from distant locations with recovery of viable, propagatable keratinocytes, facilitating long-distance collaborations.
Synthesis of substituted furans by palladium-catalyzed cyclization of acetylenic ketones (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of substituted furans by palladium-catalyzed cyclization of acetylenic ketonesYukitoshi Fukuda, Hiroshi Shiragami, Kiitiro Utimoto, and Hitosi NozakiCite this: J. Org. Chem. 1991, 56, 20, 5816–5819Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/jo00020a024https://doi.org/10.1021/jo00020a024research-articleACS PublicationsRequest reuse permissionsArticle Views1505Altmetric-Citations188LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A self-learning framework to detect the intruded integrated circuits (2016)

Globalization trends in integrated circuit (IC) design using deep submicron (DSM) technologies are leading to increased vulnerability of ICs against malicious intrusions. These malicious intrusions are referred as hardware Trojans. One way to address this threat is to utilize unique electrical signatures of ICs. However, this technique requires analyzing extensive sensor data to detect the intruded integrated circuits. In order to overcome this limitation, we propose to combine the signature extraction mechanism with machine learning algorithms to develop a self-learning framework that can detect the intruded integrated circuits. The proposed approach applies the lazy, eager or probabilistic learners to generate self-learning prediction model based on the electrical signatures. In order to validate this framework, we applied it on a recently proposed signature based hardware Trojan detection technique. The cross validation comparison of these learner shows that eager learners are able to detect the intrusion with 96% accuracy and also require less amount of memory and processing power compared to other machine learning techniques.
Recent Lipase-Catalyzed Hydrolytic Approaches to Pharmacologically Important β-and γ-Amino Acids (2012)

Kinetic and sequential kinetic enzymatic routes for the synthesis of enantiomeric β- and γ-amino acids through enzymatic ring cleavage of the corresponding lactams in organic solvents or solvent-free systems or a supercritical CO(2) medium, and for the enantioselective hydrolysis of the corresponding amino esters in organic solvents are reviewed. In the frame of a practical guide, a simple and rapid GC enantioseparation technique for amino acids, including exact descriptions of selected enzymatic reactions, is additionally presented.
Sensitivity of Pseudomonas Aeruginosa To Sulphonamides and Trimethoprim and the Activity of the Combination Trimethoprim: Sulphamethoxazole (1977)

The activities of three sulphonamides and trimethoprim against strains of Pseudomonas aeruginosa have been studied. Sulphadiazine had most activity, sulphadimidine had little, and the activity of sulphamethoxazole was intermediate. According to their sensitivity to sulphamethoxazole, strains were divided into two groups: "highly resistant" (16%, MIC greater than 1000 microgram per ml) and "moderately resistant" (84%, MIC less than or equal to 1000 microgram per ml). The former were resistant on disk testing to Sulphatriad 300 microgram. Sulphamethoxazole and trimethoprim did not act in synergy against them. The moderately resistant strains were sensitive to Sulphatriad; trimethoprim and sulphamethoxazole showed marked synergy against them in agar-plate dilution tests. The concentrations of trimethoprim and sulphamethoxazole necessary for synergy lay for each drug within the range of concentrations at which they have been found in urine, and the ratio of their MICs when acting in synergy was similar to the ratio of their concentrations in urine. It is suggested that a disk containing trimethoprim and sulphamethoxazole in a ratio of 1 : 2 rather than 1 : 20 would be more appropriate when testing strains from urine for their sensitivity to co-trimoxazole.
Preparation of Soluble Monoamine Oxidase (1954)

Since its discovery in 1928 monoamine oxidase has stubbornly resisted various attempts at purification. An explanation for this behavior emerged from the demonstration of the enzyme's intimate adherence to the cytoplasmic particulate elements. Various efforts were subsequently made to release this system into solution by means of disruption of these bodies. The result was either loss of activity or the production of smaller microscopic particles to which in turn the enzyme was attached. Such experiences strengthened the earlier opinion that "monoamine dehydrogenase" was a complex of several enzymes acting in unison or in sequence, in a fashion parallel to that postulated in the case of succinic dehydrogenase.
Development of Perovskite-type Cobaltates and Manganates for Thermoelectric Oxide Modules (2010)

Ceramics with perovskite-type structure are interesting functional materials for several energy conversion processes due to their flexible structure and a variety of properties. Prominent examples are electrode materials in fuel cells and batteries, thermoelectric converters, piezoelectrics, and photocatalysts. The very attractive physical-chemical properties of perovskite-type phases can be modified in a controlled way by changing the composition and crystallographic structure in tailor-made soft chemistry synthesis processes. Improved thermoelectric materials such as cobaltates with p-type conductivity and n-type manganates are developed by following theoretical predictions and tested to be applied in oxidic thermoelectric converters.
Synthesis and Properties of Novel Unsaturated Organosilicon Starburst and Polymer Materials via Ruthenium Catalyzed Reactions (2004)

The paper reports methods for synthesis of molecular and macromolecular organosilicon compounds containing arylene-silylene-vinylene sequence. The methods based on silylative coupling condensation and polycondensation catalyzed by ruthenium complexes containing or generating Ru–H bond lead to stereo and regio-selective synthesis of polymers and copolymers–poly(arylene-vinylene-silylene)s as well as starburst derivatives with silicon-bridgedπ-conjugated fragments. Also functionalization of cyclosiloxanes and cyclosilazanes with styrene furnish new monomers for ROP giving potentially products with silylene-vinylene-phenylenes.
The genome of minute virus of mice, an autonomous parvovirus, encodes two overlapping transcription units (1983)

Four virus-specific transcripts have been identified in murine cells infected with Minute-Virus-of-Mice (MVM). These RNAs, 4.8, 3.3, 3.0 and 1.8 kilobases in length, designated R1 to R4 respectively, are all transcribed from the virion (-) strand of DNA and they are all polyadenylated and spliced. The R1 transcript is derived from sequences that reside on the genome between 4.0 and 95 map units (mu). Transcript R2 is composed of exon sequences derived from mu coordinates 4.0-10.0, 40-46 and 48-95. The most abundant RNA, R3, is transcribed from sequences mapping between 40 and 95 mu. All three of these RNAs have a short intron sequence between 46-48 mu removed. The least abundant transcript, R4, has not been mapped precisely, however it hybridizes with all three EcoRI fragments which span the entire 5 kb genome. In vitro transcription of cloned restriction fragments of MVM DNA confirm the existence of functional promoters at map coordinates 4.0 and 39 and sequence analysis of these regions of the viral DNA reveal the characteristic features of RNA polymerase II promoters. These results indicate that MVM DNA encodes two overlapping transcription units with separate promoters near the left end (4.0 mu) and middle (39 mu) of the genome.
Data Concerning the Formation of New Afferent Pathways of the Bladder and Large Intestine - USSR -. (1960)

Abstract : It has been known for a long time that traumas of the spinal cord and, especially, a complete severance lead to grave impairments of the function of the internal orsans and the lower extremities. The urinary bladder suffers gravely (I. S. Babehin, 1954; A. N. 3akulev, 1944; A. V. 3ondarchuk, 1942; A. I. Vasil'yev, 1942; A. P. Frumkin, 1944; V. N. Shamov, 1944, etc0)0 The problem of restora tion of the function of the urinary bladder and other organs of the small pelvis also continues to remain urgent (Ye. F. flasova, 1958; M. R. Kasatkin, 1958, etc.). Since in traumas of the spinal cord the innervation apparatus and the conducting pathways of the organs of the small pelvis undoubtedly suffer and the available collateral pathways are not always capable of compensating substantially for the missing function, we have undertaken to study the formation of new collateral innervation
Phase I trial of docetaxel/prednisone plus fractionated dose radiolabeled anti-prostate-specific membrane antigen (PSMA) monoclonal antibody <sup>177</sup>lu-J591 in patients with metastatic, castration-resistant prostate cancer (mCRPC). (2014)

5064 Background: Docetaxel remains a standard agent for mCRPC and has radiosensitizing properties. 177Lu-J591 delivered with fractionated dosing leads to less myelosuppression while maintaining efficacy in mCRPC. This study was designed to determine the safety, dose limiting toxicity (DLT) and maximum tolerated dose (MTD) of fractionated 177Lu-J591 administered concurrently with standard docetaxel. Methods: Men with progressivemCRPC received docetaxel 75 mg/m2 every 3 weeks with escalating 2 fractionated doses of 177Lu-J591 (initial dose 20 mCi/m2 x2 up to max of 40 mCi/m2 x2) with cycle 3. Cycle 4 of docetaxel was planned 6 weeks after cycle 3 to allow for recovery from 177Lu-J591-associated hematologic toxicity. DLT was defined as delay in docetaxel >3 weeks, prolonged myelosuppression or need for >2 platelet (plt) transfusions, febrile neutropenia, or grade >2 non-heme toxicity following 177Lu-J591. PSA was assessed prior to each cycle and CTC count (CellSearch) was assessed at baseline and after 177Lu-J591. Results: 15 men with median age 67.3 (range 49.2-80.8), PSA 84.3 (17-776), 73.3% with elevated LDH, 71.4% unfavorable CTC counts received up to the highest anticipated dose (40 mCi/m2 x2). No DLT was seen at any dose level. Significant toxicity was limited to reversible myelosuppression. Gr 4 neutropenia without fever occurred in 3 (20%) and Gr 4 plts in 2 (13.3%), with 2 receiving prophylactic plt transfusion. No Gr >2 non-heme toxicity was observed. 13 had PSA decline, with 11 (73.3%) and 12 (80%) having >50% and >30% PSA decline respectively. All 14 evaluable men had decline (85.7%) or persistently undetectable (14.3%) CTC counts, with 78.6% having CTC counts decline by >50% and 78.6% having favorable counts after 177Lu-J591. Of 10 analyzed to date, all had targeting of known sites of disease by planar 177Lu-J591 imaging. Conclusions: The combination offractionated dose 177Lu-J591 and docetaxel/prednisone is well tolerated in patients with mCRPC. Without pre-selection, accurate targeting of known sites of disease and a strong preliminary efficacy signal was observed. Clinical trial information: NCT00916123.
A Hybrid Haptic Sensation for Teleoperation of Hydraulic Manipulators (2015)

In this paper, a control scheme is designed for stable haptic teleoperation of hydraulic manipulators. The controller results in a stable position tracking for the hydraulic actuator (slave) in both unconstrained and constrained motions. The force feedback at the haptic (master) side is a combination of two different sensations. For free motion, the haptic device provides a haptic force based on the position error between the displacements of the master and the slave. The force also serves to alert the operator when the slave is ahead or behind in position tracking of the master. Once the slave comes in contact with the environment, the haptic force is augmented by the interaction force. The uniqueness, continuation, and existence of the Filippov solution to this system with the discontinuity surfaces are proven first. The extension of Lyapunov's stability theory to nonsmooth systems is then employed to prove the stability by constructing a Lyapunov function. The effectiveness of the controller is validated via experimental studies. It is shown that while stable, the system performs well in terms of position tracking of the hydraulic actuator and providing a haptic feel to the operator. The measurements required by the controller are supply pressure, actuator's line pressures, interaction force, and displacements of the master and slave.