gebhart/patrepeval huggingface dataset:
Synthesis and function of Actinomyces naeslundii T14V type 1 fimbriae require the expression of additional fimbria-associated genes (1997)

The nucleotide sequence of the chromosomal DNA flanking the Actinomyces naeslundii (formerly A. viscosus) T14V type 1 fimbrial structural subunit gene (fimP) was determined. Six open reading frames (ORFs), in the order 5' ORF3, ORF2, ORF1,fimP, ORF4, ORF5, ORF6 3', were identified. ORF1 encoded a protein of 408 amino acid residues (Mr = 39,270) and had significant sequence homology with the A. naeslundii T14V type 1 and A. naeslundii WVU45 type 2 fimbrial structural subunits. An in-frame fusion of ORF1 to the malE gene of the expression vector, pMAL-c2, yielded a protein that was immunostained with antibodies raised against the maltose binding protein and A. naeslundii T14V whole bacteria. Digestion of the fusion protein with factor Xa released a protein (apparent molecular mass of 34 kDa) that was immunostained only with the antibody directed against A. naeslundii T14V whole bacterial cells. Integration plasmids carrying a kanamycin resistance gene (kan) that was used to substitute for ORF1 or for DNA fragments internal to the coding region of the other five ORFs were used to transform A. naeslundii T14V. Neither type 1 fimbriae nor the 65-kDa fimbrial structural subunit was detected in mutants obtained by allelic replacement of ORF1 or ORF2. Mutants obtained by allelic replacement of ORF3 or ORF4 expressed only the 65-kDa fimbrial structural subunit. These mutants did not bind, in vitro, to proline-rich proteins that serve as the receptors for Actinomyces type 1 fimbriae. In contrast, a mutant in which the integration plasmid DNA had been inserted at a site close to the carboxyl terminus of ORF6 expressed type 1 fimbriae and had adherence properties similar to those observed in the wild-type strain. These results demonstrate the existence of additional genes near fimP that are likely to be involved in the synthesis and function of cell surface fimbriae of A. naeslundii T14V.
Rituximab Administration within 6 Months of T Cell-Depleted Allogeneic SCT is Associated with Prolonged Life-Threatening Cytopenias (2010)

The monoclonal anti-CD20 antibody Rituximab (RTX) is increasingly used in allogeneic stem cell transplantation (SCT) to treat lymphoproliferative disorders and chronic graft-versus-host disease (GVHD). RTX administration can be complicated by delayed and prolonged neutropenia, but the mechanism is unclear. We report the occurrence of profound cytopenias following RTX given in the conditioning regimen or early after T cell-deplete SCT to treat B cell lymphoproliferative disorders or chronic GVHD (cGVHD). Between 2006 and 2009, 102 patients (median age: 43 years, range: 13-68 years), received a myeloablative matched-sibling T cell-deplete SCT for lymphoid or myeloid hematologic disorders. Neutropenia occurring within 4 weeks of treatment developed in 16 of 17 patients given RTX within the first 190 days after SCT. Fourteen patients developed severe neutropenia (count <0.5 K/μL) lasting up to 10 months and 12 required hospitalization to treat severe neutropenic infections. Six of the 14 patients died of infection complicating GVHD treatment. Recovery of lymphocytes and immunoglobulins was also delayed, with a significantly lower absolute lymphocyte counts (ALC) at 9 months and 12 months post-SCT compared to patients with cGVHD not treated with early RTX (P < .02). In contrast, patients receiving RTX 1 year after SCT experienced only moderate neutropenia 3 to 5 months after treatment lasting 10 to 20 days while maintaining absolute neutrophil count (ANC) >1.0 × 10⁹/L. Although RTX rapidly controlled cGVHD, we conclude that its administration early after T cell-deplete SCT is associated with prolonged profound and life-threatening cytopenias, and should be avoided.
Protective role of tetrahydrocurcumin and chlorogenic acid on glycoprotein changes in streptozotocin-nicotinamide-induced diabetic rats (2009)

The present study was to evaluate the individual and synergistic effect of two-plant derived phenolic compounds, namely tetrahydrocurcumin (THC) and chlorogenic acid (CGA) on glycoprotein levels in plasma, liver and kidney of normal and streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats. A single intraperitoneal injection of STZ (45 mg/kg b.w) to rats, lead to a significant (p &lt; 0.05) increase in the levels of fasting plasma glucose and glycoproteins (hexose, hexosamine, fucose and sialic acid), whereas the levels of plasma insulin decreased significantly (p&lt;0.05). THC (80 mg/kg b.w) and CGA (5 mg/kg b.w) as individual and combined dose were administered to diabetic rats for a period of 45 days. The levels of plasma insulin, glucose and glycoproteins were measured. From these observed findings, we suggest that the combined THC/CGA treatment shows more effective than individual treatments in decreasing plasma glucose, glycoproteins and increase insulin levels. This shows significant protection of THC/CGA over glycation of membrane proteins against STZ-NA-induced diabetic rats.
Two-stage 48 V power pod exploration for 64-bit microprocessor (2003)

In this paper, a new two-stage structure is proposed. For the first stage, a concept of energy transfer by the leakage inductor combined with the resonance is used to achieve a simple, high efficiency isolation stage. Application of this concept leads to the discovery of a family of simple, high efficiency DC/DC transformers. In order to achieve optimal system performance, the intermediate bus voltage is also investigated. Finally, The experimental results are provided.
Indentation behaviour and wear resistance of pseudoelastic Ti–Ni alloy (2000)

Recent studies demonstrate that near equiatomic Ti–Ni alloys possess high resistance to surface damage by wear. It is suggested that the high wear resistance of Ti–Ni alloys is closely correlated to their pseudoelasticity, which is usually evaluated by tensile testing. However, when a Ti–Ni alloy is under wear, its surface is in a complex stress state. Since the thermoelastic martensitic transformation of Ti–Ni alloys responds differently to different stresses, it may not be appropriate to evaluate the pseudoelasticity by tensile testing. The present paper reports recent work on pseudoelastic behaviour of a Ti–51 at.-%Ni alloy employing a microindentation technique as well as tensile testing methods. In the present work, the wear performances of Ti–51 at.-%Ni alloy specimens with different degrees of pseudoelasticity were also investigated, and efforts were made to explain the beneficial effect of pseudoelasticity on the wear resistance of Ti–Ni alloys.
Organic light-emitting devices based on aromatic polyimide doped by electrophosphorescent material<i>fac</i>tris(2-phenylpyridine) iridium (2003)

We report on the performance of a fabricated organic light-emitting device employing the electrophosphorescent material, fac tris(2-phenylpyridine) iridium (Ir(ppy)(3)), doped into the new polyimide type of polymer, aromatic polyimide host. The luminance and the external quantum efficiency of the host emitter can be improved to similar to50 000 cd m(-2) and similar to7%, respectively, by doping the host with Ir(ppy)(3). The photoluminescence (PL) and electroluminescence (EL) have been investigated. The EL spectra shift with the changes of the concentration of Ir(ppy)(3). Bright green emission was observed from the EL devices. The current-voltage (I-V) characteristics suggest that, when the voltage is higher than the turn-on voltage, the current of the doped cell is higher than that of the undoped cell at the same voltage, indicating that the doping has an effect on the I-V characteristics.
Dynamic Memory Demand Estimating Based on the Guest Operating System Behaviors for Virtual Machines (2011)

In the virtualized environment, memory can be efficiently utilized if the dynamic memory demands of virtual machines can be estimated at runtime. An efficient memory estimator should report the appropriate size of the memory which can be made full use of by the virtual machine while keeping reasonable performance. However, the appropriate size is hard to be estimated accurately with low overhead. This paper presents a memory demand estimator based on the guest operating system behaviors architecturally visible to the virtual machine monitor, and it can accurately reports the expected appropriate memory size with negligible overhead. The estimator consists of two components which respectively, track the amount of the memory residing in virtual address space, and the memory used as page cache only accessible in kernel mode. The experimental results show that the estimation error is only 0.4%~2.1%, and the runtime overhead is only 0.8% on average due to no additional memory protection traps are introduced.
Design and implementation of bias sequence circuits for GaN HEMT amplifiers both pulsed and CW applications (2013)

GaN HEMT with silicon substrate is famous and considered as the next generation of RF power transistor technology. It has major advantages of high power, low cost and reliability etc., GaN HEMT requires special attention in bias circuit to avoid the instability of the device. Sequence circuit is required to supply voltages in order. In this paper, we have design and implemented the sequential circuits in bias network for pulsed and CW applications. MAX881R is used in power supply for pulsed while LTI1964ES5-BYP with R2D Recon 2405 is used for high current application in CW. For pulsed applications in ON sequence the gate is turned-on ~ 220 ms before the drain, while in OFF sequence the drain is turned-off ~ 1.7 s before the gate. While in CW applications in ON sequence the gate is turned-on ~ 130ms before the drain and in OFF sequence, the drain is turned-off ~ 633ms before the gate.
The Remarkable Vestibuloocular Reflex (1987)

The amazing ability of the eye to remain fixed on a target during rapid movements of the head depends on the familiar automatic control mechanism known as the vestibuloocular reflex. This article presents new information about this reflex in the control of eye movement and the stabilization of eye position. The reflex is found to be highly adaptive, including the curious recent finding that imaginary visual information can initiate plastic changes.
3D whole tooth model from CT volume using thin-plate splines (2005)

As the tooth root has similar bone density with the jaw where it is embedded, its complete boundaries are either missing or at low contrast in the computed tomography (CT) volume data. This paper proposes a consistent semi-automatic landmarks selection and replacing procedure, then uses thin-plate splines to deform a 3D geometric prior model to match the 3D patient CT volume, producing a "best-fit" patient specific polygonal mesh of the whole tooth.
The effect of supplementary light on the production and behaviour of dairy cows (1989)

ABSTRACT In experiment 1, 12 cows (treatment L) received natural daylight (mean 8 h), 10 h supplementary light (mean intensity 481 lux) and dark (mean 6 h), and 12 cows (treatment N) received natural daylight (mean 8 h) and dark (mean 16 h) for 8 weeks. Supplementary light increased milk yield and tended to increase food intake and loss of live weight. There were no significant effects on milk composition although milk fat concentration tended to be reduced for cows in treatment L. Daily feeding times were not affected by treatment although more feeding took place during the supplementary light in treatment L. Supplementary light increased the time spent lying down per day and reduced the distance walked per day, although cows in treatment L spent less time lying during the light supplementation period. In both treatments, the activity rate was increased on the day of oestrus, but in treatment L the incidence of oestrus-specific behaviour was significantly reduced compared with treatment N. In experiment 2, 16 cows received natural daylight (mean 9 h) and 10 h supplementary light of mean intensity 0, 101, 191 or 529 lux in a change-over design. There were no significant effects of supplementary light or its intensity on the food intake, milk yield or live-weight change of the cows, but milk fat concentration was reduced for cows receiving supplementary light at 101 or 529 lux and milk protein concentration was reduced for cows receiving light at 529 lux.
Using Really Simple Syndication (RSS) to enhance student research (2006)

Really Simple Syndication (RSS) is a tool used in business and by users for gleaning relevant information from the Internet. RSS technology can be used in the education environment to enhance research methods for students. Students can use RSS to glean current information from on-line journals, publications, web logs and other sources without visiting the sites daily. A combination of RSS and personal web files can be used for student group projects to connect the students and share research over the Internet.
Healing of chronic leg ulcers in the hemoglobinopathies with perilesional injections of granulocyte-macrophage colony-stimulating factor. (1999)

To the Editor:

Chronic leg ulcers in patients with inherited hemoglobin disorders are a cause of pain, repulsive appearance, disability, absence from or inability to work, and are a considerable cost. Conventional treatment is often disappointing. Their cause is complex. In most instances, they
Sumatriptan/naproxen sodium combination for the treatment of migraine (2008)

Sumatriptan 85 mg with naproxen sodium 500 mg, a combination tablet for the acute treatment of migraine, is approved in the USA. It is likely that triptan/NSAID combination benefits are a class effect, although the majority of data are on sumatriptan and naproxen sodium. The combination tablet demonstrated superior effectiveness over its individual components or placebo in two Phase III regulatory trials on six coprimary end points. The pharmacokinetic shifts in the combination tablet result in an earlier T(max) for sumatriptan, a later T(max) for naproxen sodium and a reduction of the C(max) by 36% for naproxen sodium compared with the components alone. In addition, the 85 mg dose of sumatriptan in the combination tablet has an area under the curve similar to 100 mg of sumatriptan alone. The clinical advantage of the sumatriptan and naproxen sodium combination is likely to be prolonged benefit per attack, that is, a sustained pain-free response.
Generation of Molecular Recognition Sites in Electrospun Polymer Nanofibers via Molecular Imprinting (2005)

A simple method for the formation of molecular recognition sites in polymer nanofibers was developed. Electrospun nanofibers were prepared from a solution mixture of poly(ethylene terephthalate) (PET) and polyallylamine in the presence of a template molecule, 2,4-dichlorophenoxyacetic acid (2,4-D). The polyamine was used to provide functional groups that interact with the template during the electrospinning process, and PET acted as a major supporting matrix to ensure easy fiber formation and to minimize the conformational change of the polymers when the nanofibers were subjected to different solvent treatments. When the template was removed by solvent extraction, imprinted binding sites were left in the nanofiber materials that are capable of selectively rebinding the target molecule. The molecularly imprinted nanofibers were characterized by SEM, FT-IR, and radioligand binding analysis.
Ultra-wideband P-3 and CARABAS II foliage attenuation and backscatter analysis (2002)

Two-way foliage attenuation measurements from UHF and VHF SAR images collected from several USA forests and an empirical model of two-way attenuation versus center frequency are presented. Comparisons of UHF and VHF clutter backscatter coefficient distributions are made for different forest areas and terrain slopes. UHF two-way attenuation and backscatter coefficient statistics are presented for different polarization channels.
Studies in the Sphingolipids Series. IV.<sup>1</sup> Determination of the Configuration of the Amino Carbon Atom in Sphingosine<sup>2</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in the Sphingolipids Series. IV.1 Determination of the Configuration of the Amino Carbon Atom in Sphingosine2M. PROSTENIK, M. MUNK-WEINERT, and D. E. SUNKOCite this: J. Org. Chem. 1956, 21, 4, 406–409Publication Date (Print):April 1, 1956Publication History Published online1 May 2002Published inissue 1 April 1956https://pubs.acs.org/doi/10.1021/jo01110a007https://doi.org/10.1021/jo01110a007research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Host specificity in diatom–bacteria interactions alleviates antagonistic effects (2019)

While different microalgae tend to be associated with different bacteria, it remains unclear whether such specific associations are beneficial for the microalgae. We assessed the impact of bacterial isolates, derived from various marine benthic diatoms, on the growth of several strains belonging to the Cylindrotheca closterium diatom species complex. We first tested the effect of 35 different bacterial isolates on the growth of a single C. closterium strain, and then evaluated the impact of 8 of these isolates on the growth of 6 C. closterium strains and 1 Cylindrotheca fusiformis strain. Surprisingly, most interactions were neutral to antagonistic. The interactions were highly specific, with diatom growth in the presence of specific bacteria differing between Cylindrotheca strains and species, and closely related bacteria eliciting contrasting diatom growth responses. These differences could be related to the origin of the bacterial isolates, as only isolates from foreign diatom hosts significantly reduced diatom growth, implying coadaptation between different Cylindrotheca strains and their associated bacteria. Interestingly, the antagonistic effect of a Marinobacter strain was alleviated by the presence of a microbial inoculum that was native to the diatom host, suggesting that coadapted bacteria might also benefit their host indirectly by preventing the establishment of harmful bacteria.
New Zealand Fungi (1968)

Summary Some brief remarks are made about phial ides and two methods by which they may proliferate. Generic descriptions are given for Menispora Pers. and Codinaea Maire. Although the type material of C. aristata , the type species of Codinaea , has not been seen, the generic name is considered to be an earlier synonym of Menisporella Agnthothrudu. The type species of Menisporella , M. assamica , is illustrated and redescribed from the type. Species described and illustrated from New Zealand include two of Menispora , M. ciliata Corda and M. uncinata n. sp., and 12 of Codinaea , C. botulispora n. sp., C. brevisetula n. sp., C. fertilis n. sp., C. longispora n. sp., C. obesispora n. sp., C. parva n. sp., C. setosa n. sp., C. simplex n. sp., and C. vulgaris n. sp., together with the perithecial and Codinaea states of Chaetosphaeria callimorpha (Mont.) Sacc., C. dingleyae Hughes, Kendrick and Shoemaker n. sp. and C. pulchriseta Hugh., Kendr., and Shoem. n. sp. Chaetosphaeria talbotii Hugh., Kendr., and Shoem. n. sp. and its Codinaea state from South Australia is also described and illustrated. Two species described originally in M enispora , M. apicalis Berk. and Curt. and M. glauconigra Cooke and Ellis, are transferred to Codinaea . One new species of Menisporopsis Hughes from New Zealand is illustrated and described as M. novae‐zelandiae . A key is provided for the New Zealand species of Menispora , Codinaea , and Menisporopsis .
Composition of an Extracellular Polysaccharide Produced by Sphaerotilus natans1 (1962)

The capsular polysaccharide of Sphaerotilus natans has been isolated, purified, and analyzed. Chromatographic and chemical analyses performed on acid hydrolyzates of the purified material have shown that the major components are fucose, galactose, glucose, and glucuronic acid in approximately equimolar amounts. Glucose and glucuronic acid are believed to occur as an aldobiuronic acid unit.
Incidence and Natural History of Below-Knee Deep Venous Thrombosis in High-Risk Trauma Patients (2002)

Patients identified as high-risk by our practice management guideline had a 14.1% incidence of a BKDVT; 94.1% were diagnosed within the first 3 weeks of hospitalization. Proximal propagation occurred in 4.7% and led to changes in management. Serial duplex examination of the BKDVT alone, rather than systemic anticoagulation or IVC filter placement, appears to be a reasonable treatment alternative.
Analysis of Double Knockout Mice Lacking Aquaporin-1 and Urea Transporter UT-B (2002)

We reported increased water permeability and a low urea reflection coefficient in Xenopus oocytes expressing urea transporter UT-B (former name UT3), suggesting that water and urea share a common aqueous pathway (Yang, B., and Verkman, A. S. (1998) J. Biol. Chem. 273, 9369-9372). Although increased water permeability was confirmed in the Xenopus oocyte expression system, it has been argued (Sidoux-Walter, F., Lucien, N., Olives, B., Gobin, R., Rousselet, G., Kamsteeg, E. J., Ripoche, P., Deen, P. M., Cartron, J. P., and Bailly, P. (1999) J. Biol. Chem. 274, 30228-30235) that UT-B does not transport water when expressed at normal levels in mammalian cells such as erythrocytes. To quantify UT-B-mediated water transport, we generated double knockout mice lacking UT-B and the major erythrocyte water channel, aquaporin-1 (AQP1). The mice had reduced survival, retarded growth, and defective urinary concentrating ability. However, erythrocyte size and morphology were not affected. Stopped-flow light scattering measurements indicated erythrocyte osmotic water permeabilities (in cm/s x 0.01, 10 degrees C): 2.1 +/- 0.2 (wild-type mice), 2.1 +/- 0.05 (UT-B null), 0.19 +/- 0.02 (AQP1 null), and 0.045 +/- 0.009 (AQP1/UT-B null). The low water permeability found in AQP1/UT-B null erythrocytes was also seen after HgCl(2) treatment of UT-B null erythrocytes or phloretin treatment of AQP1 null erythrocytes. The apparent activation energy for UT-B-mediated water transport was low, <2 kcal/mol. Estimating 14,000 UT-B molecules per mouse erythrocyte, the UT-B-dependent P(f) of 0.15 x 10(-4) cm/s indicated a substantial single channel water permeability of UT-B of 7.5 x 10(-14) cm(3)/s, similar to that of AQP1. These results provide direct functional evidence for UT-B-facilitated water transport in erythrocytes and suggest that urea traverses an aqueous pore in the UT-B protein.
Method for Attenuation Calibration of Dual Wavelength Raman Distributed Temperature Sensing Systems (2013)

Abstract In this paper we report on a novel technique of applying dual-wavelength Distributed Temperature Sensing (DTS) interrogators to auto-adjust for differential attenuation caused by macro-bending and scattering/absorption based losses. We present the results of a comparison between dual-wavelength technology and traditional single wavelength systems.