gebhart/patrepeval huggingface dataset:
The <i>Ketel</i> Gene Encodes a Drosophila Homologue of Importin-β (2000)

The Drosophila melanogaster Ketel gene was identified via the Ketel(D) dominant female sterile mutations and their ketel(r) revertant alleles that are recessive zygotic lethals. The maternally acting Ketel(D) mutations inhibit cleavage nuclei formation. We cloned the Ketel gene on the basis of a common breakpoint in 38E1. 2-3 in four ketel(r) alleles. The Ketel(+) transgenes rescue ketel(r)-associated zygotic lethality and slightly reduce Ketel(D)-associated dominant female sterility. Ketel is a single copy gene. It is transcribed to a single 3.6-kb mRNA, predicted to encode the 97-kD Ketel protein. The 884-amino-acid sequence of Ketel is 60% identical and 78% similar to that of human importin-beta, the nuclear import receptor for proteins with a classical NLS. Indeed, Ketel supports import of appropriately designed substrates into nuclei of digitonin-permeabilized HeLa cells. As shown by a polyclonal anti-Ketel antibody, nurse cells synthesize and transfer Ketel protein into the oocyte cytoplasm from stage 11 of oogenesis. In cleavage embryos the Ketel protein is cytoplasmic. The Ketel gene appears to be ubiquitously expressed in embryonic cells. Western blot analysis revealed that the Ketel gene is not expressed in several larval cell types of late third instar larvae.
Thermal Induction Plasma Processes for the Synthesis of SOFC Materials (2002)

This work demonstrates the potential of two recently developed plasma spray methods to deposit Sr-doped La-(Mn,Fe,Co) perovskite (LSM, LSF, LSCF) cathodes, and yttria-doped zirconia (YSZ) electrolytes as components of solid oxide fuel cells (SOFC). These methods are Thermal Plasma Chemical Vapour Deposition (TPCVD) and Suspension Plasma Spraying (SPS). The microstructure obtained is determined by the method applied. TPCVD results in either globular or columnar coatings which were deposited with growth rates up to 30 μm/min. SPS with a deposition rate in excess of 100 μm/min yields coatings of layered microstructure. The homogeneity of the dopant distribution and the phase purity of YSZ is excellent. Process modifications will be necessary, however, to improve the properties in the case of perovskite coatings. Thermische Induktionsplasmaverfahren zur Synthese von SOFC-Materialien Diese Arbeit demonstriert das Potenzial zweier junger Varianten des Plasmaspritzens, der durch ein thermisches Hochfrequenz-Plasma unterstützten chemischen Abscheidung aus der Dampfphase (Thermal Plasma Chemical Vapour Deposition, TPCVD) und des Suspensionsplasmaspritzens (SPS) zur Abscheidung von Sr-dotierten La-(Mn,Fe,Co)-Perowskit (LSM, LSF, LSCF)-Kathoden und Yttria-dotierten Zirconia (YSZ)- Elektrolyten für SOFC. Die Mikrostruktur der erzeugten Schichten ist abhängig vom eingesetzten Verfahren. So wurden mittels TPCVD globulare oder stängelige Schichten mit Wachstumsraten bis 30 μm/min abgeschieden. Beim SPS entstehen bei Auftragsraten größer als 100 μm/min weitgehend lagige Schichten. Die Homogenität der Dopandenverteilung sowie die Phasenreinheit der Schichten sind im Falle des YSZ hervorragend. Jedoch müssen sie für die Perowskitschichten durch Prozessmodifikationen weiter verbessert werden.
PTH and interactions with bisphosphonates. (2000)

We report that a therapeutic dose of the antiresorptive bisphosphonate alendronate administered to skeletally mature rats for the duration of 16 weeks significantly blunted the anabolic response to a high dose SDZ PTS 893 in the tibia and femur but not in lumbar vertebra. Effects were seen at the level of bone mass (DEXA, pQCT) as well as in biomechanical tests. In one arm of this study, rats were switched to vehicle injections after 8 weeks on alendronate for another 8 weeks before being challenged with the anabolic stimulus (washout). This recovery period was insufficient for full recovery and the response to SDZ PTS 893 was still greatly reduced after this procedure. Serial pQCT-measurements suggest that part of the interaction happened during the first two weeks of PTH treatment when bone-lining cells are activated by the anabolic drug. In addition bisphosphonate pretreated rats failed to catch up with the vehicle control at all time points suggesting a second level of drug interaction. The failure of the 'washout' period to restore the normal response to PTH is suggestive of a physico-chemical interaction on the level of the matrix embedded bisphosphonate with the overlaying bone lining cells, rather than of direct effects of the drug on osteoblasts or their precursor cells. Overall the data raises the possibility, that bisphosphonate treated patients respond to PTH and SDZ PTS 893 with a delay which could affect the shorter bone mass measurements carried out at 6 months to 1 year. Additionally, bisphosphonate pre-treated rats did not develop the full anabolic response over time. Clinical investigators studying anabolic drugs such as PTH should be aware of potential long-term interactions of bisphosphonates when assessing the outcome of their experiments. However, the beneficial effect of bisphosphonates like alendronate on PTH-induced bone remodeling, as well as its potent action in the protection of bone loss after cessation of anabolic therapy might outweigh the worries about a small delay in the bone response to parathyroid hormone.
Anaerobic digestion as final step of a cellulosic ethanol biorefinery: Biogas production from fermentation effluent in a UASB reactor—pilot‐scale results (2010)

In order to lower the costs for second generation bioethanol from lignocellulosic biomass anaerobic digestion of the effluent from ethanol fermentation was implemented using an upflow anaerobic sludge blanket (UASB) reactor system in a pilot-scale biorefinery plant. Both thermophilic (53 degrees C) and mesophilic (38 degrees C) operation of the UASB reactor was investigated. At an OLR of 3.5 kg-VS/(m(3) day) a methane yield of 340 L/kg-VS was achieved for thermophilic operation (53 degrees C) while 270 L/kg-VS was obtained under mesophilic conditions (38 degrees C). For loading rates higher than 5 kg-VS/(m(3) day) the methane yields were, however, higher under mesophilic conditions compared to thermophilic conditions. The conversion of dissolved organic matter (VS(diss)) was between 68% and 91%. The effluent from the ethanol fermentation showed no signs of toxicity to the anaerobic microorganisms. However, a high content of suspended matter reduced the degradation efficiency. The retention time of the anaerobic system could be reduced from 70 to 7 h by additional removal of suspended matter by clarification. Implementation of the biogas production from the fermentation effluent accounted for about 30% higher carbon utilization in the biorefinery compared to a system with only bioethanol production.
[Digestive cancers in France. Comparison of the incidence in 7 departments and estimation of incidence in the entire country of France]. (1992)

Estimation of differences in the incidence of digestive cancers in France was made from incidence data coming from 7 French departments covered by population-based registries. For some localizations, such as cancer of the pancreas, incidence variations could be explained by differences in recording techniques. But geographic variations clearly appeared for digestive tract cancers: the incidence of esophageal cancer is 4 to 5 fold less in the departments of Tarn and Haute-Garonne than in the department of Calvados. Conversely, the incidence of colorectal cancer is lower in the department of Calvados than in the others. For the entire country, the estimated number of digestive cancers is 46,300 cases per year. This number represents a third of all cancers in males and a fourth in females. Colorectal cancer (25,700 cases per year) is the most frequent of all cancers in both sexes. Cancer of the stomach (8,200 cases per year) is the second digestive cancer, equal to esophageal cancer in males. The heavy burden of digestive cancers in public health is emphasized by our results. These results should lead our country to intensify research in the direction of primary and secondary prevention.
General route to highly functionalized cyclopentane derivatives by intramolecular C-H insertion (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral route to highly functionalized cyclopentane derivatives by intramolecular C-H insertionDouglass F. Taber and Eric H. PettyCite this: J. Org. Chem. 1982, 47, 24, 4808–4809Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/jo00145a050https://doi.org/10.1021/jo00145a050research-articleACS PublicationsRequest reuse permissionsArticle Views1718Altmetric-Citations142LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Relationship between colonial morphology and adherence of Streptococcus pneumoniae (1995)

Phase variants in colonial opacity of pneumococci differ in the ability to colonize the nasopharynx of infant rats. To explain this observation at a cellular level, we compared the ability of opacity variants to adhere to buccal epithelial cells, type II pneumocytes, or vascular endothelial cells and to the glycoconjugates that represent the cognate receptors at each of these sites. The transparent phenotype was associated with enhanced adherence to buccal cells (approximately 100%) and their receptor relative to that of the opaque variants. Only modest differences in adherence (< 45%) were demonstrated to resting lung and vascular cells. In contrast, adherence of transparent variants increased by 90% to lung cells stimulated with interleukin-1 and by 130% to endothelial cells stimulated with tumor necrosis factor. In contrast, cytokine stimulation did not influence the adherence of opaque pneumococci. This difference correlated with the unique ability of transparent variants to adhere to immobilized GlcNAc and to cells bearing transfected platelet-activating factor receptors. These results suggest that the mechanism of enhanced colonization of the nasopharynx in vivo by transparent as compared with opaque phase variants involves a greater ability to adhere to both GlcNAc beta 1-3Gal on buccal epithelial cells and GlcNAc and PAF receptors on cytokine-activated, as opposed to resting, lung and endovascular cells.
An 8-bit, 1mW successive approximation ADC in SOI CMOS (2003)

A low-power 8-bit successive approximation Analog to Digital Converter (ADC) was designed and fabricated in a 0.5/spl mu/m Silicon on Sapphire CMOS technology. The ADC is capable of 32MHz operation, producing 1.23MS/s, consuming 1.5mW at 3.3V supply. It uses an active area of 450/spl times/315/spl mu/m/sup 2/ and 916/spl times/790/spl mu/m/sup 2/ including output pads. The acceptable input swing is 2.1V at 3.3V supply. The ADC is a mixed mode analog-digital circuitry performing algorithmic conversion of an analog input voltage into an 8-bit binary code. The lack of parasitics in the Silicon on Sapphire fabrication process simplifies the design of analog to digital converters. The circuit design is freed from the unaccounted bulk capacitances which generate feedback and corrupt the performance of the ADC at high frequency.
Memory-Constrained Security Enforcement: Evaluation of Java ME-CLDC Security and Characterization of Memory-Constrained Security (2009)

This book aims at investigating memory-constrained security by analyzing the security of Java ME-CLDC and characterizing enforceable security policies. More precisely, the main objectives are (1) evaluating and improving the security of Java ME-CLDC and (2) characterizing memory-constrained execution monitoring; an important class of security mechanisms. We conducted a vulnerability analysis of Java ME-CLDC that revealed the presence of vulnerabilities in the platform and showed how to improve the underlying security model. In addition, we conducted a risk analysis that provided a seriousness estimation of the risks associated with the uncovered vulnerabilities. To characterize memory-constrained execution monitoring, (1) we defined a new automata class, called Bounded History Automata (BHA), to specify memory-constrained EM enforcement, (2) we identified a new memory-directed taxonomy of EM-enforceable properties, and (3) we investigated the enforcement of local properties using memory-constrained EM. Our characterization covers conventional monitors as well as more powerful monitors.
All-solid-state actively mode-locked Cr:LiSAF laser (1994)

We have demonstrated an actively mode-locked Cr:LiSAF laser pumped by 659-nm radiation from an intracavity frequency-doubled diode-pumped Nd:YLF laser. The laser was tunable from 815 to 915 nm, and pulses of 30-ps duration at an average power of 3.5 mW were generated. With further development this all-solid-state system will be particularly suitable for the production of femtosecond pulses, by the technique of Kerr-lens mode locking.
Crystallization and preliminary X-ray diffraction analysis of the arginine repressor of the hyperthermophile<i>Thermotoga neapolitana</i> (2005)

The arginine repressor of Thermotoga neapolitana (ArgRTnp) is a member of the family of multifunctional bacterial arginine repressors involved in the regulation of arginine metabolism. This hyperthermophilic repressor shows unique DNA-binding features that distinguish it from its homologues. ArgRTnp exists as a homotrimeric protein that assembles into hexamers at higher protein concentrations and/or in the presence of arginine. ArgRTnp was crystallized with and without its corepressor arginine using the hanging-drop vapour-diffusion method. Crystals of the aporepressor diffracted to a resolution of 2.1 A and belong to the orthorhombic P2(1)2(1)2(1) space group, with unit-cell parameters a = 117.73, b = 134.15, c = 139.31 A. Crystals of the repressor in the presence of its corepressor arginine diffracted to a resolution of 2.4 A and belong to the same space group, with similar unit-cell parameters.
SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice (2017)

SGLT1 is required for bacterial clearance and host survival following murine Listeria infection.
Ultra-Wideband LTCC Ridge Waveguide Filters (2007)

The design and experimental validation of an ultra-wideband (UWB) filter in a low temperature co-fired ceramic (LTCC) is presented. The bandpass filter uses ridge waveguide resonators realized in LTCC by printing parallel planar conductors for the top and bottom walls and closely spaced metal filled vias for the lateral walls. Filter coupling scheme and stripline transitions are developed for the UWB requirement. The mode-matching method is used in their design. The LTCC via effect and the measurement setup are also addressed. Finally, experimental results of a nine-order filter (design passband from 3 to 9GHz) are presented
Synthesis planning in the 90’s: The WODCA system (1995)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ralf Fick, Johann Gasteiger, Wolf‐D. Ihlenfeldt; Synthesis planning in the 90’s: The WODCA system. AIP Conf. Proc. 5 April 1995; 330 (1): 526–531. https://doi.org/10.1063/1.47755 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Simultaneous adsorption of poly(vinylpyrrolidone) and cationic surfactant from their mixed solutions on silica (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimultaneous adsorption of poly(vinylpyrrolidone) and cationic surfactant from their mixed solutions on silicaKunio Esumi and Michiyo OyamaCite this: Langmuir 1993, 9, 8, 2020–2023Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/la00032a021https://doi.org/10.1021/la00032a021research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Whole-body MR angiography using two-dimensional parallel imaging (iPAT2) at 3T (2009)

Aims: MR protocols for whole-body MR angiography are limited with respect to spatial resolution and anatomic coverage secondary to maximum achievable SNR and length of data acquisition. Aim of the study was the optimization of whole-body 3D contrast enhanced MR angiography with parallel imaging in phase- and slice-encoding directions for all imaging stations in order to acquire high spatially resolved datasets in combination with single contrast injection.
Hydration and the human brain circulation and metabolism. (2015)

1Centre for Sports Medicine and Human Performance, Brunel University London, United Kingdom. 2Centre for Sport, Health and Applied Science, St Mary’s University, Twickenham, United Kingdom. 3Institute of Cardiovascular Science, University College London, United Kingdom. 4Center for Infection and Immunity Research, St George’s University of London, United Kingdom. 5Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark.
Applied physical chemistry progress report, October 1991--September 1992 (1993)

This document reports on the work done in applied physical chemistry at the Chemical Technology Division (CMT), Argonne National Laboratory (ANL), in the period October 1991 through September 1992. this work includes research into the process that control the release and transport of fission products under accident-like conditions in a light water reactor, the thermophysical properties of the metal fuel in the Integral Fast Reactor under development at ANL, and the properties of candidate tritium breeding materials in environments simulating those of fusion energy systems. Viscosity and liquidus-solidus temperatures of core-concrete mixtures were studied.
IMAGING FRACTURE NETWORKS USING JOINT SEISMIC AND ELECTRICAL CHANGE DETECTION TECHNIQUES (2016)

Abstract not provided.
General method for quantifying base adducts in specific mammalian genes. (1988)

A general method has been developed to measure the formation and removal of DNA adducts in defined sequences of mammalian genomes. Adducted genomic DNA is digested with an appropriate restriction enzyme, treated with Escherichia coli UvrABC excision nuclease (ABC excinuclease), subjected to alkaline gel electrophoresis, and probed for specific sequences by Southern hybridization. The ABC excinuclease incises DNA containing bulky adducts and thus reduces the intensity of the full-length fragments in Southern hybridization in proportion to the number of adducts present in the probed sequence. This method is similar to that developed by Bohr et al. [Bohr, V. A., Smith, C. A., Okumoto, D. S. & Hanawalt, P. C. (1985) Cell 40, 359-369] for quantifying pyrimidine dimers by using T4 endonuclease V. Because of the wide substrate range of ABC exinuclease, however, our method can be used to quantify a large variety of DNA adducts in specific genomic sequences.
Rhodium and Iridium in Organometallic Catalysis (2006)

Work to extend the catalytic chemistry of rhodium and iridium, with particular emphasis on the great versatility of the former, is outlined and summarised. Topics addressed include the design of chelating N-heterocyclic carbene ligands, and the cyclisation of alkynes using rhodium and iridium phosphine compounds as reagents or catalysts. The work was carried out by Ph.D. students sponsored through the prize awarded by Johnson Matthey to the winner of their Rhodium Bicentenary Competition.
Identification of an Evolutionarily Conserved Transcriptional Signature of CD8 Memory Differentiation That Is Shared by T and B Cells (2008)

After Ag encounter, naive lymphocytes differentiate into populations of memory cells that share a common set of functions including faster response to Ag re-exposure and the ability to self-renew. However, memory lymphocytes in different lymphocyte lineages are functionally and phenotypically diverse. It is not known whether discrete populations of T and B cells use similar transcriptional programs during differentiation into the memory state. We used cross-species genomic analysis to examine the pattern of genes up-regulated during the differentiation of naive lymphocytes into memory cells in multiple populations of human CD4, CD8, and B cell lymphocytes as well as two mouse models of memory development. We identified and validated a signature of genes that was up-regulated in memory cells compared with naive cells in both human and mouse CD8 memory differentiation, suggesting marked evolutionary conservation of this transcriptional program. Surprisingly, this conserved CD8 differentiation signature was also up-regulated during memory differentiation in CD4 and B cell lineages. To validate the biologic significance of this signature, we showed that alterations in this signature of genes could distinguish between functional and exhausted CD8 T cells from a mouse model of chronic viral infection. Finally, we generated genome-wide microarray data from tetramer-sorted human T cells and showed profound differences in this differentiation signature between T cells specific for HIV and those specific for influenza. Thus, our data suggest that in addition to lineage-specific differentiation programs, T and B lymphocytes use a common transcriptional program during memory development that is disrupted in chronic viral infection.