gebhart/patrepeval huggingface dataset:
Immunological response to recombinant VP8* subunit protein of bovine rotavirus in pregnant cattle (1995)

Bovine rotavirus VP8*, N-terminal trypsin cleavage product of VP4, was produced in Escherichia coli. To examine if this antigen could induce neutralizing antibody responses, different species of animals were immunized with the recombinant VP8* protein. The VP8* antigen was found to stimulate a neutralizing immune response in rabbits. When VP8*-immunized mice were exposed to bovine rotavirus strain C486, significantly higher antibody responses were observed than if they were only exposed to C486. To stimulate a current vaccination protocol in the field with livestock, mice were exposed to live C486 virus first and then to VP8*. These mice had the elevated immune responses indicating that VP8* could boost immunity in primed mice. The immune response to VP8* was also tested in pregnant cows. The efficacy of VP8* in stimulating milk antibody was compared with a commercial inactivated vaccine. Differences in colostral antibody titres between VP8*-vaccinated and unvaccinated cows were statistically significant (P < 0.05) and equivalent to the commercial vaccine (P = 0.0569). The milk antibody titres on day 10 were comparable between VP8*- and commercial vaccine-vaccinated animals and were significantly higher (P < 0.05) than in unvaccinated controls. Furthermore, rabbit and bovine antibodies induced by VP8* were able to neutralize different P types of bovine rotaviruses to varying degrees, suggesting that serotype-specific and cross-reactive epitope(s) are present on the VP8* protein of rotavirus. Taken together, E. coli-expressed VP8* may be useful as a subunit vaccine candidate for bovine rotavirus.
Carrier detection in the hemophilias (1987)

The subject of carrier detection in the hemophilias has received new impetus in the past several years. Treatment complications arising from clotting factor concentrates have become more evident and earlier prenatal diagnosis and new genetic markers for the clotting factor genes have focused interest on this area. Until now, carrier diagnosis has relied upon standard pedigree analysis and clotting factor assays. The results obtained using these methods are probabilistic, and the coagulation tests are unavoidably influenced by the effects of random X chromosome inactivation and the inherent variability of the methods involved. With the cloning and characterization of both factor IX and factor VIII genes, has come the capability of using gene analysis to diagnose the carrier state. This usually involves the detection of restriction fragment length polymorphisms (RFLPs) and their use as linked markers for the defective clotting factor gene. In hemophilia A, the combined use of three intragenic RFLPs and two closely linked, highly polymorphic extragenic markers will make carrier information available to approximately 90% of kindred. In hemophilia B, phenotypic analysis has been complicated by the more heterogeneous expression of the gene defect. To date, five intragenic and one closely linked RFLP have been reported, as well as two protein polymorphisms detectable by monoclonal antibody immunoassays. With the combined use of these genetic markers it is likely that accurate carrier assignment will be available to more than 80% of hemophilia B families.
A RAPID METHOD FOR THE DETERMINATION OF SILICON IN SILICO-SPIEGEL AND FERRO-SILICON. (1897)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA RAPID METHOD FOR THE DETERMINATION OF SILICON IN SILICO-SPIEGEL AND FERRO-SILICON.C. B. Murray and G. P. MauryCite this: J. Am. Chem. Soc. 1897, 19, 2, 138–139Publication Date (Print):February 1, 1897Publication History Published online1 May 2002Published inissue 1 February 1897https://pubs.acs.org/doi/10.1021/ja02076a008https://doi.org/10.1021/ja02076a008research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: EINE STEREOSELEKTIVE SYNTH. DES D,L‐C17‐CECROPIA‐JUVENILHORMONS (1972)

Abstract U 1301 Der aus Geranylacetat (I) durch Oxidation mit Selendioxid in Äthanol erhaltene Aldehyd (II) wird bei ‐10°C durch Behandlung mit äthanolischem Kaliumhydroxid zu dem Alkohol (III) hydrolysiert und mit Dihydropyran (IV) in Gegenwart von p‐Toluolsulfonsäure in den Tetrahydropyranyläther (V) übergeführt.
Neutralization of the transcription factor nuclear factor erythroid derived‐2 (NF‐E2) causes robust increases in the anti‐apoptotic protein Mcl‐1 in human neutrophils (2008)

Human neutrophils (PMNs) are short‐lived cells that undergo constitutive apoptosis in vivo . When challenged by pathogens, cytokines, or ROS, PMNs survive longer. One hallmark of prolonged PMN lifespan is up‐regulation of the anti‐apoptotic protein, Mcl‐1. We previously showed that GM‐CSF delays PMN apoptosis via the Akt pathway. Proteomic analysis of neutrophil Akt immunoprecipitates identified NF‐E2 p45 as an Akt binding protein. To explore the possible role of NF‐E2 in regulating PMN apoptosis, neutrophils collected from healthy human donors were subjected to NF‐E2 or isotope control (IC) antibodies or control buffer (Krebs) for 1 hr at 37°C. LPS, TNFα, or control buffer was then added to cells and incubated overnight at 37°C. PMNs pre‐incubated with NF‐E2 antibody showed an increase in NF‐κB activation and Mcl‐1 protein versus IC or control buffer. LPS overnight incubation caused a slight increase in Mcl‐1 protein, whereas TNFα showed no effect. Also, we demonstrated that Akt phosphorylates NF‐E2 on Ser170 and that additional Akt sites exist. Akt‐mediated NF‐E2 phosphorylation mediates its nuclear localization and DNA‐binding activity. Collectively, our results suggest that Akt regulates NF‐E2 activity and that NF‐E2 plays a role in constitutive apoptosis of human neutrophils. Neutralization of NF‐E2 causes a robust increase in PMN survival as determined by levels of the anti‐apoptotic protein, Mcl‐1. This work supported by AHA (G030700) Scientist Development Grant (MJR).
Isatis tinctoria L. (2003)

https://thekeep.eiu.edu/herbarium_specimens_byname/4406/thumbnail.jpg
Antitumoral Potential of Aerosolized Interferon-γ in Mice Bearing Lung Metastases (1994)

Cytokines and immune cells are likely to be involved in the control of lung metastasis. We have therefore investigated the possibility of inhibiting lung metastases by the means of interferon-gamma (IFN-gamma) aerosolizations in a murine model of lung cancer. A Lewis lung carcinoma (3LL) was inoculated in the thigh of C57BL/6 mice. Randomized groups of 10 mice each were then treated by repeated aerosols of IFN-gamma (4,000 U/mouse) of aerosols of a Hanks' solution as controls. When the animals were killed at 18 days, the number of lung metastatic nodules was significantly reduced (by 50%; P < 0.01) after IFN-gamma aerosols, compared with controls. When the primary tumor was resected at 18 days and aerosols were continued, in the absence of local recurrence, mice treated by IFN-gamma aerosols survived longer than did controls (P < 0.05). In vitro, IFN-gamma exerted no direct antitumoral effect on 3LL cells in culture. Macrophages recovered from mice receiving IFN-gamma aerosols showed a higher antiproliferative effect on 3LL cells in vitro than did controls. Nevertheless, the higher antiproliferative effect of activated macrophages seems insufficient to explain the difference of survival that we observed between IFN-gamma-treated mice and controls.
Diluted epoxy adhesives. I. Physical properties and lap shear strengths (1978)

A series of epoxy adhesives were prepared from a commercial bisphenol A-epichlorohydrin epoxy resin by diluting it with varying amounts of either phenyl glycidyl ether or 1,4-butanediol diglycidyl ether and curing with either diethylenetriamine (DTA) or diethylaminopropylamine (DPA). The initial physical properties (density, viscosity, and surface tension) of the epoxy solutions were determined both with and without curing agents. It was found that the surface tensions of adhesives catalyzed with DPA are initially very low (31–32 dynes/cm), and within several hours these solutions attain an equilibrium surface tension of 40–46 dynes/cm. When the steel-to-steel lap shear strengths of these adhesives were measured, a correlation was not observed between the initial properties and the strengths of these materials.
INFAB PROCESSING OF TZM SHEET (1963)

Abstract : Seven extruded billets and two of four ingot sections were successfully impact forged to sheet bar and evaluated. Each of the nine sheet bar was cut into four sections and these were rolled to 0.125 in. intermediate gauge at temperatures from 2000 to 3200 F. A total of 29 pieces of intermediate gauge strip were produced and partially evaluated for soundness and evidence of contamination.
Effects of Undernutrition on Nucleic Acid Synthesis in Neuronal and Glial Cells from Different Regions of Developing Rat Brain (1980)

Rats were undernourished by being given half their normal diet from the 10th day of pregnancy, 10-, 15- and 30-day-old rats were studied. Incorporation of labelled precursors into brain DNA and RNA was carried out in vitro with slices from cerebral cortex, brain stem and cerebellum. Neuronal and glial cells were subsequently isolated and analyzed for specific radioactivity. The proliferation and differentiation of all brain cells were affected by undernutrition. Glial cells in particular and the small neuronal cells appeared most vulnerable probably because of their intense postnatal development.
STIMULATION OF INTERNAL BREAKDOWN, RESPIRATION AND ETHYLENE EVOLUTION OF SPADONA PEARS WITH BENZIMIDAZOLE FUNGICIDES (1975)

The incidence of internal breakdown of Spadona pears (Pyrus communis L.) after 6 mo storage at −1 C, was increased by postharvest antifungal treatments with benomyl (methyl-1-(butyl-carbamyl)-2-benzimidazole-carbamate) or with thiabendazole (2-(4′thiazolyl)-benzimidazole). Susceptibility to internal breakdown was variable, with different fungicidal concentrations augmenting it to various degrees in different experiments. A stimulation of carbon dioxide and ethylene evolution was observed following cold storage when the fruit suffered from an increased incidence of internal breakdown due to treatment. When no internal breakdown occurred, or when its incidence was not increased by postharvest fungicidal treatment, no effect on the respiration rate of the fruit or its ethylene evolution was observed.
ELECTRODIALYSIS OF SHEEP ADRENOCORTICOTROPIC (ACTH) PROTEIN PREPARATIONS<sup>1</sup> (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTELECTRODIALYSIS OF SHEEP ADRENOCORTICOTROPIC (ACTH) PROTEIN PREPARATIONS1George P. Hess, J. Ieuan Harris, Frederick H. Carpenter, and Choh Hao LiCite this: J. Am. Chem. Soc. 1951, 73, 12, 5918–5919Publication Date (Print):December 1, 1951Publication History Published online1 May 2002Published inissue 1 December 1951https://pubs.acs.org/doi/10.1021/ja01156a564https://doi.org/10.1021/ja01156a564research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A 1-D Planar Solid Oxide Fuel Cell Model for Simulation of SOFC-Based Energy Systems (2004)

A one-dimensional steady-state model for planar solid oxide fuel cells (SOFCs) is presented. Appropriately simplified, the model includes sufficient detail for supporting ongoing investigations involving the simulation of SOFC-based advanced energy systems. The presentation focuses on a set of nonlinear equations accounting for conservation of mass and energy along a single SOFC in a co-flow configuration. Electrochemical models also are employed, including one previously used for a zero dimensional approach. The equations are described through a phenomenological approach based on the best recent work in the field and model validation is carried out in two distinct phases using previously published information. Potential areas of application for the model presented are noted.
De Novo Appearance of Three Cavernomas in an Infant with Dural AV Shunts (1998)

Cavernomas of the brain and spinal cord are malformations which are generally considered congenital and often found in young adults. Although the distinction of a sporadic and a hereditary type is discussed, the natural history is still poorly understood. We present the unusual case of an infant first submitted to CT scan, MRI and MR-angiography at the age of three months, revealing multiple AV shunts of the superior sagittal and the sigmoid sinus, with a small pial supply. A second angiogram at the age of six months showed an additional parietal pial AVM. At this time, partial embolisation of the dural AV shunts was performed. At the age of three, the child was restudied by MRI and three formerly invisible cavernomas were detected.
Statistical analysis of multiple cracking phenomenon of a SiOx thin film on a polymer substrate (2001)

The progress of multiple cracking in a silicon oxide (SiOx) film deposited onto a polyethylene terephthalate substrate was analyzed using Monte Carlo simulation. The finite-element analysis, assuming elastoplastic behavior of the polymer substrate, was conducted to calculate the stress distributions in film fragments and was used in the simulation. The Weibull parameters of the film were determined from the scatter of crack onset strain. The simulation predicted successfully the crack density and the distribution of fragment lengths during the progress of multiple cracking. The validity of the shear lag analysis based on the unique stress criterion in a previous study was also evaluated.
Handbook of Liquid Crystals (1998)

This four-volume reference aims to provide information on the basic principles of both low- and high-molecular weight materials, as well as the synthesis, characterization, modification, and applications (such as in computer displays or as structural materials) of all types of liquid crystals. Volume 1, for example, deals with the basic physical and chemical principles of liquid crystals, including structure-property relationships, nomenclature, phase behaviour, characterization methods, and general synthesis and application strategies.
MINERVA MEDICA COPYRIGHT (2009)

An overview of 13C nuclear magnetic resonance (NMR) spectroscopy methods and their applications in the study of the metabolism of brain cells in vitro and in the in vivo brain is presented as well as their implications for modern molecular imaging techniques. Various top- ics will be discussed, such as general properties of the 13C NMR spectrum, 13C NMR spectroscopy acquisition protocols, determination of fractional 13C enrichment, 13 C( 2 H) NMR methodologies, and the use of 13 C hyper-
Reducing the Burden of High Level Radioactive Waste with Transmutation &mdash; Proposal of Integral Molten Salt Fast Reactor (IMSFR) (2016)

The transmutation methods to reduce the burden of high level radioactive waste had been compared to identify the most suitable method for this purpose. The results showed that the molten salt reactor (MSR) was suggested to be an effective transmutation system. Based on this result, a new concept of Integral Molten Salt Fast Reactor (IMSFR) as a highly efficient transmutation system for transuranium elements has been proposed in this study; the system consists of a combination of an MSR fuelled with chloride molten salt fuel and the chloride-based pyrochemical processing subsystem. In this system MSR fuel can be transferred between the reactor core and the pyrochemical processing subsystem without chemical form change.
Do you speak «Deumildeudeu?» (2004)

<titre>Résumé</titre>La mise en œuvre de la loi 2002-2 qui précise les exigences réglementaires concernant l’ensemble des structures sociales et médico-sociales constitue une actualité majeure pour un grand nombre de lieux avec lesquels nous travaillons. Si les débats sont nombreux à son égard, nul ne peut ignorer les effets de structuration qu’elle est en train de produire et qui méritent qu’on s’y arrête. Elle constitue de ce point de vue un opérateur effectif et symbolique dont on peut essayer de pointer les incontestables aspects positifs, comme les limites ou les points aveugles. Tout particulièrement, on peut être sensible à la manière dont elle limitera ou facilitera les coopérations avec tous les acteurs, non inclus dans cette loi, mais contribuant à une action sociale qui ne se réduit pas à celle menée par les établissements.
A method for predicting stressed words in English jazz chants (2011)

To acquire a second language, one must develop an ear and tongue for the correct stress and intonation patterns of that language. In English language teaching, there is an effective method called Jazz Chants for working on the sound system. In this paper, we propose a method for predicting stressed words, which play a crucial role in Jazz Chants. The proposed method is specially designed for stress prediction in Jazz chants. It exploits several sources of information including words, POSs, sentence types, and the constraint on the number of stressed words in a chant text. Experiments show that the proposed method achieves an -measure of 0.936 and outperforms the other methods implemented for comparison. The proposed method is expected to be useful in supporting non-native teachers of English when they teach chants to students and create chant texts with stress marks from arbitrary texts.
USP7 Cooperates with SCML2 To Regulate the Activity of PRC1 (2015)

USP7 is a protein deubiquitinase with an essential role in development. Here, we provide evidence that USP7 regulates the activity of Polycomb repressive complex 1 (PRC1) in coordination with SCML2. There are six versions of PRC1 defined by the association of one of the PCGF homologues (PCGF1 to PCGF6) with the common catalytic subunit RING1B. First, we show that SCML2, a Polycomb group protein that associates with PRC1.2 (containing PCGF2/MEL18) and PRC1.4 (containing PCGF4/BMI1), modulates the localization of USP7 and bridges USP7 with PRC1.4, allowing for the stabilization of BMI1. Chromatin immunoprecipitation (ChIP) experiments demonstrate that USP7 is found at SCML2 and BMI1 target genes. Second, inhibition of USP7 leads to a reduction in the level of ubiquitinated histone H2A (H2Aub), the catalytic product of PRC1 and key for its repressive activity. USP7 regulates the posttranslational status of RING1B and BMI1, a specific component of PRC1.4. Thus, not only does USP7 stabilize PRC1 components, its catalytic activity is also necessary to maintain a functional PRC1, thereby ensuring appropriate levels of repressive H2Aub.
A micromachined RF low phase noise voltage-controlled oscillator for wireless communications (2001)

An RF low phase noise voltage-controlled oscillator is implemented with micromachined IC-compatible variable capacitors and three-dimensional coil inductor. Unlike conventional on-chip passive devices, the micromachined variable capacitors achieve a high-Q value above 60 at 1 GHz with a 15% tuning range for a nominal 2 pF capacitance with 3 V tuning voltage. Three-dimensional inductors minimize the substrate loss and achieve a Q of 30 at 1 GHz with a 4.8 nH inductance. Both passive components are fabricated on silicon substrates and thus amenable to monolithic integration with standard IC process. The prototype VCO exhibits −136 dBc/Hz phase noise at 3 MHz offset frequency from the carrier, suitable for most wireless communication applications, in particular GSM. The VCO is tunable from 855 Mhz to 863 MHz, limited by the test set-up. © 2001 John Wiley & Sons, Inc. Int J RF and Microwave CAE 11: 285–300, 2001.
Measurement of Blood Flow in the Left Ventricle and Aorta Using Clinical 2D Cine Phase-Contrast Magnetic Resonance Imaging (2007)

A recent development in phase-contrast magnetic resonance imaging (cine PC-MRI) allows the detailed measurement of the blood flow in humans. The objectives of this study are twofold: to discuss the utility of clinical two-dimensional (2D) cine PC-MRI as a practical tool for analyzing hemodynamics in the aorta and left ventricle; 2) to provide flow information at those places as references for computational fluid dynamics studies. Using 2D cine PC-MRI, we mapped velocity profiles at various cross sections of the aorta and left ventricle. The results illustrated the main flow events in the left ventricle during the cardiac cycle, such as ventricular ejection and suction, while the secondary flows were less clear. The velocity profile at the entrance of the ascending aorta appeared to be slightly skewed posteriorly in early systole, but the flow in the central zone of the section was rapid. The estimated stroke volume, peak Reynolds numbers, and Womersley numbers were within the normal physiological range. A sequence of secondary flow images from the plane of the aortic valve to the descending aorta revealed the evolution of a helical flow within the aorta. Flows entering the aortic branches were captured well. Those results demonstrate that clinical 2D cine PC-MRI is a practical adjunct for analyzing blood flow in vivo and would be useful as references to check validity of flow dynamics obtained by computer simulations.