gebhart/patrepeval huggingface dataset:
Genotype-specific weight loss treatment advice: how close are we? (2007)

Obesity, whose prevalence is continually rising, is one of the world's greatest health care burdens. This multifactorial condition is associated with many obesity-related conditions, such as type 2 diabetes, dyslipidemia, and cardiovascular disease. Weight loss is a significant challenge facing those wishing to reduce their disease risk. Of course, like obesity itself, weight loss is a complex phenomenon dependent on many environmental and genetic influences, and thus individual responses to weight loss interventions are incredibly variable. Currently, there are 3 major interventions used to reduce weight: diet, exercise, and pharmacotherapy. The findings from studies examining gene-diet (nutrigenetic), gene-exercise (actigenetic), and gene-pharmaceutical (pharmacogenetic) interactions, although not clinically applicable at this time, are gaining awareness. This review article summarizes the current evidence to support the contribution of DNA sequence variation in genes related to energy balance (expenditure and intake) in the response to weight loss intervention. There is no doubt that replication using more rigorous study designs that include the study of interactions between multiple genes and interventions is required to move towards the development of genotype-specific weight loss treatment strategies.
Internet Content Adaptation Protocol (ICAP) (2003)

ICAP, the Internet Content Adaption Protocol, is a protocol aimed at providing simple object-based content vectoring for HTTP services. ICAP is, in essence, a lightweight protocol for executing a remote procedure call on HTTP messages. It allows ICAP clients to pass HTTP messages to ICAP servers for some sort of transformation or other processing (adaptation). The server executes its transformation service on messages and sends back responses to the client, usually with modified messages. Typically, the adapted messages are either HTTP requests or HTTP responses.
Lectures on the Principles of Surgical Diagnosis: Especially in Relation to Shock and Visceral Lesions (1868)

WHmN honoured by being elected to the Professorship of Human Ana- tomy and Surgery in this College, the duties of which I am now about to fAlfil, I beme sensible of the difficulty of seecting a suitable subject on which to address so learned an audience. My attention has not been directed toany branch of anatomy or surgery the special cultivation of
Shared and Unique Roles of Cap23 and Gap43 in Actin Regulation, Neurite Outgrowth, and Anatomical Plasticity (2000)

CAP23 is a major cortical cytoskeleton-associated and calmodulin binding protein that is widely and abundantly expressed during development, maintained in selected brain structures in the adult, and reinduced during nerve regeneration. Overexpression of CAP23 in adult neurons of transgenic mice promotes nerve sprouting, but the role of this protein in process outgrowth was not clear. Here, we show that CAP23 is functionally related to GAP43, and plays a critical role to regulate nerve sprouting and the actin cytoskeleton. Knockout mice lacking CAP23 exhibited a pronounced and complex phenotype, including a defect to produce stimulus-induced nerve sprouting at the adult neuromuscular junction. This sprouting deficit was rescued by transgenic overexpression of either CAP23 or GAP43 in adult motoneurons. Knockin mice expressing GAP43 instead of CAP23 were essentially normal, indicating that, although these proteins do not share homologous sequences, GAP43 can functionally substitute for CAP23 in vivo. Cultured sensory neurons lacking CAP23 exhibited striking alterations in neurite outgrowth that were phenocopied by low doses of cytochalasin D. A detailed analysis of such cultures revealed common and unique functions of CAP23 and GAP43 on the actin cytoskeleton and neurite outgrowth. The results provide compelling experimental evidence for the notion that CAP23 and GAP43 are functionally related intrinsic determinants of anatomical plasticity, and suggest that these proteins function by locally promoting subplasmalemmal actin cytoskeleton accumulation.
'White' light laser (1983)

A He-Cd+ laser system is described which provides simultaneous laser oscillations in the three primary colours, blue, green and red. Conditions which produce the optimum 'white' light light output are specified.
IRRADIATION BEHAVIOR OF DISPERSION FUELS (1957)

The dispersion fuel concept offers a method for minimizing irradiation- induced property changes in nuclear fuel systems by localizing fission damage into regulated domains within the system. The system is thereby provided with a structural framework, or matrix, whose properties are relatively unaffected by the dynamic and impurity effects of fission fragments. Dispersion-type fuel systems whose irradiation behavior has been, or is being, investigated in the United States are listed. The extent of property retention in a dispersion fuel alloy is dependent on the materials selected for the fuel-bearing and matrix phases and on their microstructural arrangement in the alloy. The consequences of varying the materials and fuel-phase particle size and volume fraction are discussed. From experimental observations it is shown that, by proper control of these parameters within the bounds of existing technology, the dispersion concept does provide improvement in property retention over alternate alloy design concepts. (auth)
Conversion from 3371 to 1124 Å by nonresonant optical frequency tripling in compressed krypton gas (1979)

The 1-MW 3-nsec output from a commercial nitrogen laser has been frequency tripled in krypton to generate vacuum-ultraviolet 1124-A radiation. Conversion efficiencies of up to 10(-6) and optimum krypton gas pressures as high as 4-5 atm were found. Preliminary experiments using a para-terphenyl dye laser have yielded tunable radiation in the 1116-1165-A region.
Institutionalized (2012)

Editorial| March 01 2012 Institutionalized Rob White Rob White Search for other works by this author on: This Site PubMed Google Scholar Film Quarterly (2012) 65 (3): 4–6. https://doi.org/10.1525/fq.2012.65.3.04 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Rob White; Institutionalized. Film Quarterly 1 March 2012; 65 (3): 4–6. doi: https://doi.org/10.1525/fq.2012.65.3.04 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentFilm Quarterly Search This content is only available via PDF. © 2012 by the Regents of the University of California.2012 Article PDF first page preview Close Modal You do not currently have access to this content.
Selective Hydrogenation of Polyolefins with Metal Sulfide Catalysts in the Liquid Phase (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective Hydrogenation of Polyolefins with Metal Sulfide Catalysts in the Liquid PhaseR. J. Moore, R. A. Trimble, and B. S. GreensfelderCite this: J. Am. Chem. Soc. 1952, 74, 2, 373–375Publication Date (Print):January 1, 1952Publication History Published online1 May 2002Published inissue 1 January 1952https://pubs.acs.org/doi/10.1021/ja01122a025https://doi.org/10.1021/ja01122a025research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Eye-movement analysis for advanced human-computer interaction (2008)

Eye movement has been studied in many research areas and a variety of systems that can record eye movements and compute gaze locations on 2D displays have been developed. Moreover, in gaze-controlled interfaces, users can select an item from a graphical display by looking at it. However, eye movements are often involuntary, and the Midas Touch effect makes it hard to use only gaze locations to control interfaces. Therefore, in this dissertation a specific type of hybrid interfaces was introduced. In these interfaces, users select an item on the display with their gaze and then confirm the selection by pressing a button. Since moving the eyes is faster than moving the mouse, I was expecting this interface to be more efficient than the traditional mouse-controlled interface. Preliminary studies directly compared the efficiency of hybrid and mouse-controlled interfaces across different tasks and interfaces. Surprisingly, it was found that participants were more or equally efficient using mouse-controlled interfaces as compared to hybrid ones. Experiment 1 in this dissertation shows that there is a significant temporal discrepancy between the eye selection and the button confirmation (eye-hand span). I determined this span to be an important reason for the less efficient performance using the hybrid interface compared to the mouse interface. Consequently, an algorithm that compensates the eye-hand span was developed and tested in Experiment 2 in a static environment. Improvement of the subjects' performance was observed. The same algorithm was tested in a dynamic scene in Experiment 3. However, no improvement was found on the subjects' performance due to a less predictable eye-hand span in such scenarios. To search for more efficient interfaces in dynamic scenes, 3D stereo displays were employed. For this purpose, a neural network based method of 3D gaze position estimation was tested in Experiment 4 and was shown to outperform the purely geometric solution. In Experiments 5 and 6, the effects of gaze input and stereoscopic depth were studied in a monitoring task. I found that the combination of gaze input and 3D displays seems to be especially beneficial to both the subjects' cognitive parameters and their task performance.
CENTRAL NERVOUS SYSTEM NEURONAL MIGRATION (1999)

Widespread cell migrations are the hallmark of vertebrate brain development. In the early embryo, morphogenetic movements of precursor cells establish the rhombomeres of the hindbrain, the external germinal layer of the cerebellum, and the regional boundaries of the forebrain. In midgestation, after primary neurogenesis in compact ventricular zones has commenced, individual postmitotic cells undergo directed migrations along the glial fiber system. Radial migrations establish the neuronal layers. Three molecules have been shown to function in glial guided migration--astrotactin, glial growth factor, and erbB. In the postnatal period, a wave of secondary neurogenesis produces huge numbers of interneurons destined for the cerebellar cortex, the hippocampal formation, and the olfactory bulb. Molecular analysis of the genes that mark stages of secondary neurogenesis show similar expression patterns of a number of genes. Thus these three regions may have genetic pathways in common. Finally, we consider emerging studies on neurological mutant mice, such as reeler, and human brain malformations. Positional cloning and identification of mutated genes has led to new insights on laminar patterning in brain.
Multiaccess processor interconnection using subcarrier and wavelength division multiplexing (1997)

The optical technology contributes significantly to high speed long distance communications and local area networks (LANs). The wavelength division multiplexing (WDM) and the subcarrier multiplexing (SCM) are two technologies widely employed to fully utilize the huge bandwidth available on optical fibers and alleviate the speed mismatch between the components in the electronic domain and those in the optical domain. In this paper, we extend these technologies to parallel processing multicomputers. The design philosophy is to incorporate advantages of both the WDM and the SCM into the multiaccess processor interconnection for multicomputers. The objective is to provide high bandwidth and high data rate under the physical limits and the performance requirements. A novel interprocessor architecture, the receiver oriented architecture (ROA), is proposed. Based on the passive optical star coupler, the ROA has been implemented and referred as ROA-SC which is single-hop accessible and optically self-routing. The implementation also speeds up the processing in the electronic domain. Besides, the presentation includes three media access protocols for both the reservation and the preallocation approaches. Extensive analysis has been performed and the proposed ROA-SC is found to have very good modularity and scalability so that it is very suitable for practical applications.
A NEW DIAGNOSTIC PROCEDURE FOR CANCER OF THE LARYNX USING A RETRACTABLE THROAT BRUSH (1954)

The diagnosis of cancer of the larynx is dependent upon surgical biopsy from a target lesion recognizable by the otolaryngologist. Symptoms such as chronic hoarseness, cough, and hemoptysis are often present before final diagnosis for a variable period of time. A new method of collecting cells from the throat is presented here as a diagnostic aid to biopsy in visual lesions. It is proposed that clinical trials be made to determine the practicability of brush cytology as a screening method for early cancer. The common malignant lesion involving the throat is epidermoid carcinoma, the same type of neoplasm as is commonly encountered in the female uterine cervix. The widespread use of the cytological method of detection of cancer of the cervix has proved the extended duration of the preclinical carcinoma-in-situ stage. Direct cervical cell scraping yields diagnostic cells of carcinoma in situ with great accuracy during the period preceding the
The Evolution of Protein Structures (1987)

As proteins evolve, their amino acid sequences change. These changes can be large—so large that members of the same protein family may have less than one-fifth of the residues at homologous sites are identical. In most instances, the large sequence changes result in no more than a modification of functional properties. How do very different sequences give proteins with similar structures and functions? To answer this question we analyzed in detail the atomic structure of homologous proteins. We determined the effects of the sequence differences on the structures of these proteins. The analyses showed that sequence changes are accommodated by changes in structure.
The Protein Data Bank: a historical perspective (2007)

The Protein Data Bank began as a grassroots effort in 1971. It has grown from a small archive containing a dozen structures to a major international resource for structural biology containing more than 40000 entries. The interplay of science, technology and attitudes about data sharing have all played a role in the growth of this resource.
Four Functions of Digital Tools in Election Campaigns (2016)

This article presents a case study of the use of digital tools by campaign organizations in Germany’s 2013 federal election. Based on observations and in-depth interviews with key personnel in the campaigns of six of the parties running for Parliament, I examine whether German campaigns’ use of digital tools follows the usage practices that have been identified in studies of campaigns in the United States. I group how campaigns use digital tools into four categories: organizational structures and work routines, presence in information spaces online, support in resource collection and allocation, and symbolic uses. I show that these categories capture how German parties use digital tools. U.S.-based studies can thus provide helpful interpretive frameworks for studying digital campaigning in other countries. However, I also reveal that there are important differences between German and U.S.-based online campaigning. These differences stem from the different levels of intensity with which digital tools are deployed in each country.
Response of a pendulum spar to 2-dimensional random waves and a uniform current (1978)

A linearized theory for the response of a circular pen-du1um spar in .2-dimensional waves and a uniform current is deve1oped. The linear forces on the cylinder are predicted using an approximate potential flow theory for slender bodies. The dynamic equations are then amended to account for the wake effects of viscous bluff body flow by including a quadratic drag law and neglecting wave damping. A spectral model for the forces on a cylinder due to an oscillating wake, modeling the force as a frequency modulation process, is proposed. The non-linear equations of motion which result are then solved, assuming constant force coefficients, by linearization for use with a Gaussian random sea. The method of equivalent linearization is extended to include mean flow effects and a spatially distributed process. Some numerical experiments are then used to test the performnce ;. . .;:";\~ .
MOBILE ROBOTS (1991)

Mobile robots must deal with unstructured environments in order to be general and useful. Current laboratory robots often use single approach to deal with unstructured environments: position sensing, environment sensing, planning, or mechanical design. Robust robots of the future will have to use combinations of all those approaches, and also handle the difficult problems of system integration. This article is an overview of the problems to be faced and of some of the more promising approaches being investigated.
New Person-to-Person Payment Methods: Have Checks Met Their Match? (2012)

During the last decade, both demand-side and supply-side factors have contributed to a surge in new methods of making person-to-person (P2P) payments. On the demand side, the driving factors have been the emergence of new forums for commerce such as online auctions and the increasing desire by consumers to monitor and control payments. On the supply side, the main factors have been technological advancements such as faster Internet speeds, increased computing power and smartphones. Despite the surge in new P2P payment methods, studies show that consumers in the United States still prefer to make payments to other people with checks and cash. In fact, P2P payments by check are the only type of check payment that is still increasing. If consumers could be induced to use a digital alternative to P2P payments by cash and check, the efficiency and safety of the U.S. payments system might be enhanced. Three distinct models for P2P payments have emerged. In the nonbank-centric model, an individual instructs a nonbank intermediary such as PayPal to transfer funds to another consumer. In the bankcentric model, the individual interacts directly with a bank to request Terri Bradford is a payments system research specialist and William R. Keeton was an assistant vice president and economist in the Payments System Research Department of
RESEARCH ON GRADING METHOD OF COURSES BASED ON ENGINEERING PROFESSIONAL CERTIFICATION (2018)

In order to meet the requirements of engineering education professional certification, to ensure the engineering teaching quality and promote the teaching ability, the grading method of courses based on engineering professional certification is preliminary explored. The statistic method of analyzing the scores for achievement is applied for the proper evaluation of the test questions. The results show that the traditional methods of evaluation exit shortcomings. A comprehensive method to evaluate the students' course tests by combining the indexes of difficulty, distinction, effectiveness, feasibility and score distribution are proposed, a typical example is provided as an illustration.
Elimination of spot doubling in precession photography without layer-line screens (1970)

Precession photography without layer-line screens is a method in use for the efficient recording of data from crystals with large unit cells. Spot doubling in the photographs can be eliminated by the use of a rotating screen with a semicircular aperture.
The Growth of Silver Whiskers by Reduction of Silver Halogenides (1993)

Abstract By reduction of silver halogenides with hydrogen according to Brenner's method, silver whiskers were grown. Their investigation by contemporary techniques suggests that the driving force for their growth is the strongly enhanced capillary pressure in the silver halogenide droplets at the tip of the whiskers, leading to accelerated decomposition of this salt.
A mounting and alignment approach for Constellation-X mirror segments (2008)

The four Constellation-X Spectroscopy X-ray Telescopes require four sets of 2,600 thin mirror segments be supported with minimum deformation and aligned with arc-second level accuracy. We have developed a support and alignment system that minimizes segment deformation and allows the mirror segments to be made confocal. This system relies upon a set of five mirror support points at each of the forward and aft ends of each segment. The support points are radially adjustable so as to be able to modify the segment cone angles, thereby correcting any focal length errors. Additional adjustments enable correction of segment centration and tilts to correct co-alignment errors and minimize comatic aberration. The support and alignment system is described and results are presented. Included are data demonstrating minimal levels of figure distortion. Results are compared with error budget allocations.
Appropriatezza, self-audit ed estrattori in medicina generale (2019)

The author presents the results of a personal audit proposed to the GPs by the ASL 6 Euganea of the Veneto Region. The results obtained show significant differences between the data provided by the pharmaceutical sector and those obtained by consulting the individual database. The therapeutic adherence of antihypertensive drugs appears to be particularly discordant. The audit also suggests inappropriate use of PPIs, improper use of corticosteroids for aerosols after modification of the prescribability and reduced adherence to statin therapy.