gebhart/patrepeval huggingface dataset:
T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation (2017)

Allogeneic haematopoietic stem cell transplantation (HSCT) from an human leukocyte antigen (HLA)-identical donor can be curative for eligible patients with non-malignant and malignant haematological disorders. HSCT from alternative donor sources, such as HLA-mismatched haploidentical donors, is increasingly considered as a viable therapeutic option for patients lacking HLA-matched donors. Initial attempts at haploidentical HSCT were associated with vigorous bidirectional alloreactivity, leading to unacceptably high rates of graft rejection and graft-versus-host disease (GVHD). More recently, new approaches for mitigating harmful T-cell alloreactivity that mediates GVHD, while preserving the function of tumour-reactive natural killer (NK) cells and γδ T cells, have led to markedly improved clinical outcomes, and are successfully being implemented in the clinic. This article will provide an update on in vitro strategies and in vivo approaches aimed at preventing GVHD by selectively manipulating key components of the adaptive immune response, such as T-cell receptor (TCR)-αβ T cells and CD45RA-expressing naive T cells.
Radio Frequency Interference detection algorithm based on spectrogram analysis (2010)

In this work a combined frequency and time-domain algorithm has been developed to detect the presence of Radio Frequency Interference (RFI). The radiometric signal's spectrogram is treated as an image, and therefore image processing techniques can be applied in it; and hence RFI can be detected by 2D filtering. A series of Monte-Carlo simulations have been performed to evaluate the performance of this algorithm.
InP/SiO2 MIS structure (1976)

Metal-insulator-semiconductor (MIS) structures were produced by the pyrolitic deposition of SiO2 on InP. The insulating layers were hard and glasslike with a room-temperature resistivity ≳1015 Ω cm at a field of 106 V/cm. Breakdown field strengths are typically between 5×106 and 107 V/cm. The electrical properties of the InP-SiO2 interface were found to exhibit a strong dependence on the SiO2 deposition process parameters. For optimum conditions capacitance/voltage (C/V) measurements suggest that the average interface state density is ∼2×1011 cm−2 eV−1 with flat band occurring at a gate voltage of approximately −0.1 V. Triangular waveform bias sweep frequencies of ≲10−3 Hz are required to attain equilibrium C/V conditions.
Progesterone for hot flush and night sweat treatment – effectiveness for severe vasomotor symptoms and lack of withdrawal rebound (2012)

A controlled trial recently showed that oral micronized progesterone (Progesterone, 300 mg at h.s. daily) was effective for vasomotor symptoms (VMS) in 133 healthy early postmenopausal women. Here, we present subgroup data in women with severe VMS (50 VMS of moderate-severe intensity/wk) and also 1-mo withdrawal study outcomes. Women with severe VMS (n = 46) resembled the full cohort but experienced 10 VMS/d of 3 of 4 intensity. On therapy, the progesterone VMS number (#) decreased significantly more than placebo # to 5.5/day (d) versus 8/d (ANCOVA -2.0 95% CI: -3.5 to -0.4). Just after trial mid-point, a withdrawal substudy (D/C) was added--56 women were invited and 34 (61%) took part (progesterone 17; placebo 17). Those in the D/C cohort resembled the whole cohort. On stopping, VMS gradually increased--at D/C week 4, on progesterone, VMS daily # reached 78% and significantly less than baseline (-3.0 to -0.8) but placebo VMS # did not differ from run-in. In summary, progesterone is effective for severe VMS and does not cause a rebound increase in VMS when stopped. That progesterone may be used alone for severe VMS and unlike estrogen does not appear to cause a withdrawal rebound increases VMS treatment options.
A review of existing measures of attentional biases in body image and eating disorders research (2017)

Cognitive theories emphasise the important role of attentional biases in the development and maintenance of body image issues and eating pathology. A wealth of research has been conducted to examine attentional biases toward body‐related information among individuals with eating pathology. However, there is considerable variability in the methods that have been used to measure attention and, importantly, these methods tap into different attentional processes. Given the multifaceted nature of attention, it is important for researchers to select the right tools to test their hypotheses. This review critically evaluates the attentional measures that have been used in previous research, primarily the modified Stroop task, dot probe task, visual search task, and eyetracking. The strengths and limitations of each measure will be discussed in order to provide a guide for researchers to further investigate the attentional mechanisms underlying body image issues and eating disorders. Overall, we recommend that researchers use a combination of eyetracking technology and specific reaction‐time measures that target the specific attentional mechanism of interest.
Proinflammatory factors in saliva as possible markers for periodontal disease. (2005)

Studies have indicated that host inflammatory proteins, enzymes and indicators of bone metabolism present in saliva differ in different types of periodontal disease. However, the number of markers analyzed was limited and the effect of edentulousness was not examined. We measured the concentration of host inflammatory proteins: C-reactive protein (CRP), C3 and C4 complement components, alpha-2-macroglobulin (alpha-2M) and tumor-necrosis factor (TNF) in unstimulated saliva of 14 periodontally healthy (PH), 9 edentulous persons (EP), 10 patients with chronic periodontitis (CP) and 18 with aggressive periodontitis (AgP). TNF was below the level of detection in all samples except one. Edentulous persons and patients with CP had significantly reduced concentrations of CRP, C3 and alpha-2M. Edentulous persons and AgP patients had lower C4 concentrations. We can conclude that edentulous persons and CP patients have reduced salivary concentrations of host inflammatory proteins. These findings suggest that a reduction in host responsiveness might play a role in the pathogenesis of CP.
Adaptive control with a forgetting factor with multiple samples between parameter adjustments (1992)

A discrete-time adaptive control algorithm with a forgetting factor that permits multiple samples between parameter adjustments is presented. A free integer value may be chosen in the design in order to reduce the minimum sampling period imposed by the computational requirements of the parameter adjustment laws. This fact makes the algorithm particularly suitable for inexpensive microcomputer implementation. A proof of global convergence of the algorithm is presented and the performance of the control structure is evaluated by simulations.
Environment matters at the World Bank - annual review 2005 (2005)

In line with one of the major themes in the Bank's Environment Strategy, this 2005 annual review is devoted to the theme of environmental health. Viewpoint articles in this edition reflect several external perspectives: the World Health Organization (WHO) lays out the panorama of environmental risk factors; a successful example of combating urban air pollution is provided by the former mayor of Bogota; successful strategies to enhance sanitation among poor people are suggested by a nongovernmental organization (NGO) - WaterAid - with an impressive implementation record; and a leading researcher gives his perspective on indoor air pollution. As usual, Environment Matters provides a Bank-wide review of our safeguard policies, and conveys the latest data on our environmental lending and analytical work. This year's feature articles all cluster around the main theme of environmental health: Ruta and Sarraf explain the basics of economic valuation of health impacts of environmental risks; Kaufmann summarizes a recent study that provides an overview of what we know about the effectiveness of interventions in water and sanitation; Ahmed and Awe return to the theme of indoor air pollution, with a study from Guatemala; Constant and Procee explain how the Bank's Clean Air Initiative works in several regions; and, Tynan concludes the section with an article on the risks that chemicals pose to human health. This edition reviews each of the Bank's Regions. With attention to the environmental health theme, each Region has chosen a number of issues and projects to feature in their annual review. This section illustrates the diversity of issues the Bank is confronting in collaboration with client countries. The regional reviews are complemented by the institutional perspectives of the International Finance Corporation (IFC), which deals with private sector development, and the World Bank Institute, which is responsible for capacity building in client countries.
ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism (2009)

Motor proteins couple steps in ATP binding and hydrolysis to conformational switching both in and remote from the active site. In our kinesin.AMPPPNP crystal structure, closure of the active site results in structural transformations appropriate for microtubule binding and organizes an orthosteric two-water cluster. We conclude that a proton is shared between the lytic water, positioned for gamma-phosphate attack, and a second water that serves as a general base. To our knowledge, this is the first experimental detection of the catalytic base for any ATPase. Deprotonation of the second water by switch residues likely triggers subsequent large scale structural rearrangements. Therefore, the catalytic base is responsible for initiating nucleophilic attack of ATP and for relaying the positive charge over long distances to initiate mechanotransduction. Coordination of switch movements via sequential proton transfer along paired water clusters may be universal for nucleotide triphosphatases with conserved active sites, such as myosins and G-proteins.
Evaluation of Bottom Hole Pressures in 40 Soft Rock Frac-Pack Completions in the Gulf of Mexico (1994)

Abstract The purpose of this paper is to share findings that resulted from a study of pressures recorded from bundle carrier and wash pipe gauges run during frac-packing operations. The original premise was to correctly evaluate and identify fracture pressure responses associated with the "tip-screen-out" techniques used for frac-pack placement. The first attempts at frac pack pressure evaluation were done using data collected from bundle carriers in the workstring. Once washpipe data was obtained, it was noted that the bundle carrier data was distorted by phenomenon below the gauges in the well bore. The fluid friction generated through the crossover tool and friction associated with the slurry path around the screen proved to be a source of the observed distortion. Data collected from bottom hole pressure gauges attached to the wash pipe below the gravel pack running tool indicated that in several cases the observed pressure increase is associated with friction and not from the fracture inflation associated with "tip-screen-outs." It was noted that serious swabbing effects can accompany the movement of the service tool. This swabbing has in the past been considered negligible. The swab effect can potentially damage the completion beyond repair. This swab can pull formation material into the perforations tunnels and annulus, creating a severe pressure drop through that portion of the perforated interval. The implications can be detrimental to well performance. Early BHP data collection altered procedures for service tool movement and provided insight toward correcting friction pressure calculations.
A study of the discharge coefficient of jets from angled slots and conical orifices (2000)

grantor: University of Toronto
A CAM-Based, High-Performance Classifier-Scheduler for a Video Network Processor. (2008)

Classification and scheduling are key functionalities of a network processor. Network processors are equipped with application specific integrated circuits (ASIC), so that as IP (Internet Protocol) packets arrive, they can be processed directly without using the central processing unit. A new network processor is proposed called the video network processor (VNP) for real time broadcasting of video streams for IP television (IPTV). This thesis explores the challenge in designing a combined classification and scheduling module for a VNP. I propose and design the classifier-scheduler module which will classify and schedule data for VNP. The proposed module discriminates between IP packets and video packets. The video packets are further processed for digital rights management (DRM). IP packets which carry regular traffic will traverse without any modification. Basic architecture of VNP and architecture of classifier-scheduler module based on content addressable memory (CAM) and random access memory (RAM) has been proposed. The module has been designed and simulated in Xilinx 9.1i; is built in ISE simulator with a throughput of 1.79 Mbps and a maximum working frequency of 111.89 MHz at a power dissipation of 33.6mW. The code has been translated and mapped for Spartan and Virtex family of devices.
A Five- to Fifteen-Year Follow-up Study of Infantile Psychosis (1969)

Surprisingly little is known about the course of intellectual development in children with infantile psychosis. Kanner (1943; Kanner and Lesser, 1958) has stated explicitly in several papers that “even though most of these children are initially considered feeble-minded, they are all unquestionably endowed with good cognitive potentialities , which are masked by the basic disorder” (original italics—Kanner and Lesser, 1958). The expectation would seem to be that the child's IQ, should fluctuate with the course of the psychosis, particularly the autistic aspects, but this has not been tested. It has been suggested (Anthony, 1958) that an intelligence test result in a young child with infantile psychosis is most unreliable and virtually meaningless if the child is without speech. Perhaps because most investigators have shared this view, neither of the two major follow-up studies of children with infantile psychosis, that of Kanner's cases (Eisenberg, 1956; Eisenberg and Kanner, 1956; Kanner, 1943 and 1949; Kanner and Eisenberg, 1955; Kanner and Lesser, 1958) and that of psychotic children seen by Creak (1962, 1963 a and b ) has included information on IQ changes.
導言: 生死決策的西方思想困境與儒家軟實力 (2009)

LANGUAGE NOTE | Document text in Chinese生死決策是人生最重要的決策，也是生命倫理學中最艱難的決 策。本期的六篇論文，除了最後一篇論述長期照護的政策之外，其餘各篇均探討生死決策問題，特別是有關墮胎、臨終關懷以及自殺方面的決策問題。綜合看來，這些論文表達了兩方面的思想。一方面是，西方主流生命倫理學在生死決策方面陷入了困境，難以自拔；另一方面是，儒家傳統在生死決策方面具有豐富的資源，構成了不同於西方主流思想的軟實力，值得我們認真探索。本前言將依據各篇論文，概述這兩方面的思想，供讀者參考。DOWNLOAD HISTORY | This article has been downloaded 147 times in Digital Commons before migrating into this platform.
Rhodiola crenulata inhibits the tumorigenic properties of invasive mammary epithelial cells with stem cell characteristics. (2010)

446-454
Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies: use of fluorescent lipids to study lipid-body formation in an oleaginous fungus (2000)

Fluorescent phosphatidic acid and phosphatidylcholine were used to characterize lipid-transport pathways into lipid bodies in an oleaginous fungus, Mortierella ramanniana var. angulispora. Several characteristics of the lipid transport such as temperature dependence and ATP dependence were evaluated. The transport depicted by these fluorescent lipids was consistent with metabolism of radiolabelled lipids, indicating that fluorescent lipids are useful to study lipid-body formation in this fungus. The results dissect lipid transport of phosphatidic acid and phosphatidylcholine into lipid bodies and reveal regulatory steps for lipidbody formation in this fungus.
Upper limit of cerebral autoregulation during development of hypertension in spontaneously hypertensive rats--effect of sympathetic denervation. (1985)

The upper limit of cerebral autoregulation was studied in pre- or early established hypertension in spontaneously hypertensive rats (SHR). Cerebral blood flow (CBF) was measured with the hydrogen clearance method, and wall/lumen ratio of cerebral arteries was morphometrically measured with the freeze-substitution technique. To test autoregulation, phenylephrine was intravenously infused to cause stepwise increments of blood pressure. Unilateral superior cervical ganglionectomy was carried out to examine the effects of sympathetic denervation on CBF autoregulation and thickness of vascular wall. Resting blood pressure at 4 weeks, 3 months and 6 months of age were 89 +/- 3 mm Hg (mean +/- SEM), 140 +/- 6 and 165 +/- 6, respectively. Baseline CBF was slightly diminished with age; 50.6 +/- 9.2 ml/100 g/min at 4 weeks, 49.8 +/- 8.1 at 3 months and 44.1 +/- 5.6 at 6 months. The upper limit of autoregulation was markedly raised with age; 118 +/- 5 mm Hg at 4 weeks, 180 +/- 7 at 3 months and 208 +/- 10 at 6 months. Acute sympathetic denervation lowered the upper limits to 105 +/- 2, 162 +/- 4 and 185 +/- 7 mm Hg, respectively. On the other hand, in chronic denervation which was made at 4 weeks of age, the upper limit of autoregulation in the denervated hemisphere was slightly lower than that in innervated hemisphere at 2 months (165 +/- 5 and 178 +/- 6 mm Hg), and at 5 months (202 +/- 8 and 215 +/- 8 mm Hg) after ganglionectomy.(ABSTRACT TRUNCATED AT 250 WORDS)
Ephedrine, xanthines and prostaglandin-inhibitors: actions and interactions in the stimulation of thermogenesis. (1993)

The pivotal role of the sympathoadrenal system in the defense of le milieu interieur has, in the last 15 years, been extended to include the fat stores-a notion that forms the basis of current strategies for thermogenic stimulation in obesity therapy. The search for effective and safe sympathetic stimulants has been directed at two main levels: (i) the development of novel beta-agonists selective for thermogenesis, and (ii) the evaluation of drugs already in clinical use for other purposes (e.g. ephedrine) which could conceivably increase the release of catecholamines to levels that enhance thermogenesis without significant cardiovascular effects. A re-direction of these strategies seem inevitable because at therapeutic doses, the thermogenic effects of these sympathomimetics seem to be considerably dampened by negative feedback mechanisms that operate both extracellularly (e.g. via adenosine & prostaglandins) as well as inside the cells (via cAMP phosphodiesterases). Such a contention is supported by studies both in man and in animals showing that methylxanthines and aspirin, drugs known to be capable of interfering with these modulators, potentiate the thermogenic effects of ephedrine. Future research aimed at clarifying the types and subtypes of these negative modulators of sympathomimetic-induced thermogenesis and their targeting by more selective antagonists would no doubt be pivotal in providing the safe drug combination with the necessary thermogenic properties to assist the management of obesity.
Promoting ecologic health resilience for minority youth: Enhancing health care access through the school health center (2003)

Abstract Ethnic minority youth experience problems in access to healthcare, yet little is known about how to enhance utilization. This article will discuss the demographic realities of children of color in the United States, with a focus on health care needs and access issues that have an enormous influence on health status. The article will consider health policy as it describes the considerable barriers to quality health care for minority youth such as a lack of a usual source of care and limited health insurance. An ecologic model is presented that incorporates cultural values and community structures into the school health center. Enhancing access and utilization through the school setting is viewed as promoting ecologic resilience in youth. © 2003 Wiley Periodicals, Inc. Psychol Schs 40: 265–278, 2003.
Stroke Lesion Detection Using Convolutional Neural Networks (2018)

Stroke is an injury that affects the brain tissue, mainly caused by changes in the blood supply to a particular region of the brain. As consequence, some specific functions related to that affected region can be reduced, decreasing the quality of life of the patient. In this work, we deal with the problem of stroke detection in Computed Tomography (CT) images using Convolutional Neural Networks (CNN) optimized by Particle Swarm optimization (PSO). We considered two different kinds of strokes, ischemic and hemorrhagic, as well as making available a public dataset to foster the research related to stroke detection in the human brain. The dataset comprises three different types of images for each case, i.e., the original CT image, one with the segmented cranium and an additional one with the radiological density's map. The results evidenced that CNN's are suitable to deal with stroke detection, obtaining promising results.
Magneto-optical visualization of metal-loss defects in a ferromagnetic plate: experimental verification of theoretical modeling (2001)

Rare-earth iron garnet films with in-plane magnetic anisotropy grown on [111]-oriented substrates are promising for the visualization of magnetic leakage fields in nondestructive evaluation. Such magneto-optical films have to be specifically engineered, and we give an example of this technology. To assess the validity and accuracy of finite-element calculations of a magnetization assembly combined with the physical modeling of the image formation, comparisons between calculated and experimentally obtained magneto-optical images of metal-loss defects have been made. A convincing quantitative agreement is demonstrated. It is shown that both physical and computer modeling techniques allow for a predictive engineering design of the prospective applications and provide greater insight into the method.
Preparation of a Comb-Shaped Cholic Acid-Containing Polymer by Atom Transfer Radical Polymerization (2006)

ADVERTISEMENT RETURN TO ISSUEPREVNotePreparation of a Comb-Shaped Cholic Acid-Containing Polymer by Atom Transfer Radical PolymerizationJinqing Hao, Hong Li, and X. X. ZhuView Author Information Key Laboratory of Functional Polymeric Materials, Institute of Polymer Chemistry, Nankai University, Tianjin, 300071, China, and Department of Chemistry, Université de Montréal, C. P. 6128, Succursale Centre-ville, Montreal, QC, H3C 3J7, Canada Cite this: Biomacromolecules 2006, 7, 3, 995–998Publication Date (Web):January 31, 2006Publication History Received21 November 2005Revised24 December 2005Published online31 January 2006Published inissue 1 March 2006https://pubs.acs.org/doi/10.1021/bm0508865https://doi.org/10.1021/bm0508865brief-reportACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views423Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Monomers,Polymerization,Polymers,Radical polymerization Get e-Alerts