gebhart/patrepeval huggingface dataset:
M<scp>ACRONUTRIENT</scp> U<scp>TILIZATION BY</scp> P<scp>HOTOSYNTHETIC</scp> E<scp>UKARYOTES AND THE</scp> F<scp>ABRIC OF</scp> I<scp>NTERACTIONS</scp> (2001)

Organisms acclimate to a continually fluctuating nutrient environment. Acclimation involves responses specific for the limiting nutrient as well as responses that are more general and occur when an organism experiences different stress conditions. Specific responses enable organisms to efficiently scavenge the limiting nutrient and may involve the induction of high-affinity transport systems and the synthesis of hydrolytic enzymes that facilitate the release of the nutrient from extracellular organic molecules or from internal reserves. General responses include changes in cell division rates and global alterations in metabolic activities. In photosynthetic organisms there must be precise regulation of photosynthetic activity since when severe nutrient limitation prevents continued cell growth, excitation of photosynthetic pigments could result in the formation of reactive oxygen species, which can severely damage structural and functional features of the cell. This review focuses on ways that photosynthetic eukaryotes assimilate the macronutrients nitrogen, sulfur, and phosphorus, and the mechanisms that govern assimilatory activities. Also discussed are molecular responses to macronutrient limitation and the elicitation of those responses through integration of environmental and cellular cues.
The Application of Failure Analysis in Procuring and Screening of Integrated Circuits (1965)

The procedure for the testing, screening, and lot rejection of integrated circuits for the Apollo Guidance and Navigation Computer is described. The procedure, based on a knowledge of failure modes, failure mechanisms and contributing causes to failures in the manufacturing of devices, attempts to increase the reliability of integrated circuits. This is accomplished by screening and analyzing weak devices and using the generated data to quantitatively assess the lot for acceptance, rework or rejection. The technique, which is primarily aimed toward high-usage high-volume devices, was developed after extensive testing of many tens of thousands of integrated circuits. The process documents included in the appendix contain stress test procedures, classification of failure modes, numerical rejection limits per class of failure modes, internal visual rejection criteria, and leak test procedures. To emphasize the need for the described technique, data is presented showing variations among vendors and variation among procurement lots shipped from a single vendor. The contributing factors to the variations are discussed. A discussion of the evolution of the process documents is presented. The ultimate goal of the documents is the elimination or minimization of detected failure modes, Failure studies have shown that some failure modes are screenable with high confidence whereas attempts to screen other types of failure modes merely decrease the life of the device. In the later case, the detection durng short term stressing of devices which exhibit long time dependent failure modes is a low probability event.
Crosstalk model of a deformable-mirror-based infrared scene projector (1994)

An analytical model for crosstalk is developed for an infrared scene projector that utilizes a deformable-mirror device as an infrared spatial light modulator. Partial-coherence effects that result from the physical layout of the projection system are included. Crosstalk is determined by defining a crosstalk ratio in the projected image. Crosstalk-ratio calculations are carried out for monochromatic and blackbody projection sources over the 3- to 5-μm wavelength band. The results predict crosstalk ratios of 260:1, 1200:1, and 2400:1 for deformable-mirror pixels of 50, 100, and 150 μm when a blackbody source is used in the projection system. Crosstalk performance is improved at shorter wavelengths and for larger deformable-mirror pixels. The results of a proof-of-principle experiment are included to verify the feasibility of a deformable-mirror device in the projection system.
Continuous-wave nonlinear optics in low-stress silicon-rich nitride waveguides (2015)

We demonstrate CW-pumped wavelength conversion in low-stress silicon-rich nitride waveguides. The ability to grow thick silicon-rich layers simultaneously enables high-field confinement, dispersion engineering and handling high-power levels without two-photon absorption effects.
Experimental support for a β-propeller domain in integrin α-subunits and a calcium binding site on its lower surface (1998)

Integrins are large, heterodimeric surface molecules of wide importance in cell adhesion. The N-terminal half of all integrin alpha-subunits contains seven weak sequence repeats of approximately 60 amino acids that are important in ligand binding and have been predicted to fold cooperatively into a single beta-propeller domain with seven beta-sheets. We provide evidence supporting this model with a mouse mAb to human Mac-1 (alphaM beta2, CD11b/CD18). This antibody, CBRM1/20, binds to amino acid residues that are in different repeats and are 94 residues apart in the primary structure in the loop between strands 1 and 2 of beta-sheet 5 and in the loop between strands 3 and 4 of beta-sheet 6. The 1-2 loops of beta-sheets 5-7 in integrins have EF hand-like Ca2+-binding motifs. CBRM1/20 binds to Mac-1 in the presence of Ca2+ or Sr2+ with an EC50 of 0.2 mM. Mg2+ or Mn2+ cannot substitute. Antibodies to other epitopes on the Mac-1 beta-propeller domain bind in the absence of calcium. mAb CBRM1/20 does not block ligand binding. Thus, the region on the lower surface of the beta-propeller domain to which mAb CBRM1/20 binds does not bind ligand and, furthermore, cannot bind other integrin domains, such as those of the beta-subunit.
Inversion of the anomeric configuration of the transferred sugar during inactivation of the macrolide antibiotic oleandomycin catalyzed by a macrolide glycosyltransferase (2000)

Macrolides are a group of antibiotics structurally characterized by a macrocyclic lactone to which one or several deoxy-sugar moieties are attached. The sugar moieties are transferred to the different aglycones by glycosyltransferases (GTF). The OleI GTF of an oleandomycin producer, Streptomyces antibioticus, catalyzes the inactivation of this macrolide by glycosylation. The product of this reaction was isolated and its structure elucidated. The donor substrate of the reaction was UDP-alpha-D-glucose, but the reaction product showed a beta-glycosidic linkage. The inversion of the anomeric configuration of the transferred sugar and other data about the kinetics of the reaction and primary structure analysis of several GTFs are compatible with a reaction mechanism involving a single nucleophilic substitution at the sugar anomeric carbon in the catalytic center of the enzyme.
The Basicity of Alcohols and Ethers (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Basicity of Alcohols and EthersN. C. Deno and John O. TurnerCite this: J. Org. Chem. 1966, 31, 6, 1969–1970Publication Date (Print):June 1, 1966Publication History Published online1 May 2002Published inissue 1 June 1966https://pubs.acs.org/doi/10.1021/jo01344a506https://doi.org/10.1021/jo01344a506research-articleACS PublicationsRequest reuse permissionsArticle Views429Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cavitation Performance of a Centrifugal Pump with Water and Mercury (1961)

http://deepblue.lib.umich.edu/bitstream/2027.42/5291/5/bac3392.0001.001.pdf
ChemInform Abstract: Synthesis of Antibiotic A25822 B. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
42 GHz waveguide germanium-on-silicon vertical PIN photodetector (2008)

High speed, high responsivity and reliable CMOS compatible photodetectors are key elements for low cost telecommunications systems at 1.55 mum. A 42 GHz germanium on silicon vertical PIN photodetector integrated in SOI waveguide is presented.
ANALISIS MULTICAPA DE3 COMPOSITES. APLICACION AL ESTUDIO ItNTERLAMINAR DE TECHOS DE AUTOBUS (1986)

SUMMARY This paper exposes a theoretical and experimental study relative to the multilayer aspect of the composite materials. The laboratory tests have been made with the gentle colaboration of Cristaleria Espanola, S.A. In the last part of the paper, an application to bus ceilingsmade of glass fibre-reinforced poliester is described. This is a subject of actuality due to the recent publication of the 36th normative of buses homologation. This application has been made in collaboration with the firm Hispano Carrocera, S.A.
Spectrum and Energy Efficient Block Edge Mask-Compliant Waveforms for Dynamic Environments (2014)

This paper suggests that the regulatory tool known as the Block Edge Mask (BEM), which is used to define the technical conditions governing a spectrum license, can be used as an instrument to jointly drive spectrum and energy efficiency in a network. The paper explores this concept and goes on to show how networks can generate waveforms which comply with the energy limits of the BEM and at the same time make best use of the spectral resources available to them. The focus of the paper is on orthogonal frequency division multiplexing (OFDM) waveforms. The spectrum- and energy-efficient BEM-compliant waveforms are generated using a process that optimally combines symbol shaping and subcarrier-power loading to create a waveform that minimizes the difference between the transmitted wave and BEM. Practical considerations relating to peak-to-average-power-ratio (PAPR) reduction and time and frequency synchronization issues are explored to ensure the BEM-compliant waveforms can be transmitted with minimal changes to the transceiver. It is envisaged that these techniques will be used by transmitters that change their frequency of operation and in doing so need to shape their transmitted waveforms to comply with the different BEMs governing the use of the different spectrum blocks they wish to access.
Vapor transport deposition of cadmium telluride films (2003)

Polycrystalline CdTe thin films are grown by vapor transport deposition onto moving substrates using a linear cross-web source for operation at low vacuum and high growth temperature. The source design, based on delivery of a carrier gas saturated with Cd and Te/sub 2/ vapors, overcomes the limitations of other vapor deposition methods. Models for vapor transport deposition and radiative transfer within the source facilitate a quantitative understanding of source behavior leading to control of film deposition. The deposition has been characterized over a wide range of operating parameters. Dense, single phase device quality CdTe films have been fabricated. Deposition of other compound semiconductor materials has also been demonstrated.
Effect of Repeated Applanation Tonometry on the Accuracy of Intraocular Pressure Measurements (2010)

Patients with glaucoma show a decrease in IOP on repeated applanation tonometry measurements. By contrast, in individuals without glaucoma, no significant decrease in IOP on repeated applanation tonometry measurements was found.
A prospective study on size and function of paediatric kidneys (<10 years) transplanted to adults (2007)

The study indicates that paediatric kidneys for transplantation may be considered as excellent rather than being referred to as suboptimal for adult recipients, at least the first year after transplantation.
Implementing and programming causal distributed shared memory (2002)

A simple owner protocol for implementing a causal distributed shared memory (DSM) is presented, and it is argued that this implementation is more efficient than comparable coherent DSM implementations. Moreover, it is shown that writing programs for causal memory is no more difficult than writing programs for atomic shared memory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Calcium Intake and Body Weight1 (2000)

Five clinical studies of calcium intake, designed with a primary skeletal end point, were reevaluated to explore associations between calcium intake and body weight. All subjects were women, clustered in three main age groups: 3rd, 5th, and 8th decades. Total sample size was 780. Four of the studies were observational; two were cross-sectional, in which body mass index was regressed against entry level calcium intake; and two were longitudinal, in which change in weight over time was regressed against calcium intake. One study was a double-blind, placebo-controlled, randomized trial of calcium supplementation, in which change in weight during the course of study was evaluated as a function of treatment status. Significant negative associations between calcium intake and weight were found for all three age groups, and the odds ratio for being overweight (body mass index, >26) was 2.25 for young women in the lower half of the calcium intakes of their respective study groups (P: < 0.02). Relative to placebo, the calcium-treated subjects in the controlled trial exhibited a significant weight loss across nearly 4 yr of observation. Estimates of the relationship indicate that a 1000-mg calcium intake difference is associated with an 8-kg difference in mean body weight and that calcium intake explains approximately 3% of the variance in body weight.
Fishing for newly synthesized proteins with phosphonate-handles (2020)

Bioorthogonal chemistry introduces affinity-labels into biomolecules with minimal disruption to the original system and is widely applicable in a range of contexts. In proteomics, immobilized metal affinity chromatography (IMAC) enables enrichment of phosphopeptides with extreme sensitivity and selectivity. Here, we adapt and combine these superb assets in a new enrichment strategy using phosphonate-handles, which we term PhosID. In this approach, click-able phosphonate-handles are introduced into proteins via 1,3-dipolar Huisgen-cycloaddition to azido-homo-alanine (AHA) and IMAC is then used to enrich exclusively for phosphonate-labeled peptides. In interferon-gamma (IFNγ) stimulated cells, PhosID enabled the identification of a large number of IFN responsive newly synthesized proteins (NSPs) whereby we monitored the differential synthesis of these proteins over time. Collectively, these data validate the excellent performance of PhosID with efficient analysis and quantification of hundreds of NSPs by single LC-MS/MS runs. We envision PhosID as an attractive and alternative tool for studying stimuli-sensitive proteome subsets.
Crystal Engineering of an nbo Topology Metal–Organic Framework for Chemical Fixation of CO<sub>2</sub> under Ambient Conditions (2014)

Crystal engineering of the nbo metal-organic framework (MOF) platform MOF-505 with a custom-designed azamacrocycle ligand (1,4,7,10-tetrazazcyclododecane-N,N',N'',N'''-tetra-p-methylbenzoic acid) leads to a high density of well-oriented Lewis active sites within the cuboctahedral cage in MMCF-2, [Cu2(Cu-tactmb)(H2O)3(NO3)2]. This MOF demonstrates high catalytic activity for the chemical fixation of CO2 into cyclic carbonates at room temperature under 1 atm pressure.
Barth syndrome cells display widespread remodeling of mitochondrial complexes without affecting metabolic flux distribution (2018)

Barth syndrome (BTHS) is a rare X-linked disorder that is characterized by cardiac and skeletal myopathy, neutropenia and growth abnormalities. The disease is caused by mutations in the tafazzin (TAZ) gene encoding an enzyme involved in the acyl chain remodeling of the mitochondrial phospholipid cardiolipin (CL). Biochemically, this leads to decreased levels of mature CL and accumulation of the intermediate monolysocardiolipin (MLCL). At a cellular level, this causes mitochondrial fragmentation and reduced stability of the respiratory chain supercomplexes. However, the exact mechanism through which tafazzin deficiency leads to disease development remains unclear. We therefore aimed to elucidate the pathways affected in BTHS cells by employing proteomic and metabolic profiling assays. Complexome profiling of patient skin fibroblasts revealed significant effects for about 200 different mitochondrial proteins. Prominently, we found a specific destabilization of higher order oxidative phosphorylation (OXPHOS) supercomplexes, as well as changes in complexes involved in cristae organization and CL trafficking. Moreover, the key metabolic complexes 2-oxoglutarate dehydrogenase (OGDH) and branched-chain ketoacid dehydrogenase (BCKD) were profoundly destabilized in BTHS patient samples. Surprisingly, metabolic flux distribution assays using stable isotope tracer-based metabolomics did not show reduced flux through the TCA cycle. Overall, insights from analyzing the impact of TAZ mutations on the mitochondrial complexome provided a better understanding of the resulting functional and structural consequences and thus the pathological mechanisms leading to Barth syndrome.
Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101. (2002)

High-grade dysplasia induced by high-risk types of human papillomavirus (HPV) precedes invasive cancer in anal squamous epithelium just as it does in the cervix. A therapeutic HPV vaccine strategy as a potential treatment for anal dysplasia was tested in a standard Phase I dose escalation trial. The primary objective was to evaluate the safety of the agent; additional study aims were to evaluate the histological response, immune response, and effect on anal HPV-16 infection. Each subject was treated with four i.m. injections of 50-400 microg of ZYC101 at 3-week intervals. ZYC101 is composed of plasmid DNA encapsulated in biodegradable polymer microparticles. The plasmid DNA encodes for multiple HLA-A2-restricted epitopes derived from the HPV-16 E7 protein, one of two HPV oncoproteins consistently expressed in neoplastic cells. Fifty-six potential anal dysplasia subjects were screened to identify 12 eligible subjects with HPV-16 anal infection and a HLA-A2 haplotype. The investigational agent was well tolerated in all subjects at all dose levels tested. Three subjects experienced partial histological responses, including one of three subjects receiving the 200-microg dose and two subjects at the 400-microg dose level. Using a direct Elispot, 10 of 12 subjects demonstrated increased immune response to the peptide epitopes encoded within ZYC101; each continued to show elevated immune responses 6 months after the initiation of therapy. These results support the continued investigation of a therapeutic vaccination strategy for anal dysplasia.
Identification of Species-Specific and Gender-Specific Proteins and Glycoproteins of Three Human Schistosomes (1983)

Species-specific and gender-specific polypeptides of Schistosoma haematobium, Schistosoma japonicum, and Schistosoma mansoni have been identified. Proteins of these schistosomes were metabolically labeled in vitro with 35S-methionine and their total proteins, concanavalin-A binding glycoproteins, released (shed or secreted) proteins, and released glycoproteins compared by two-dimensional polyacrylamide electrophoresis. Many of the released proteins were glycosylated, and most of the synthesized glycoproteins were released. The most striking gender-specific and species-specific differences were observed in the released glycoproteins. These results provide a basis for investigating the molecular evolution of schistosomes, the occurrence of dioecy in the schistosomatidae , and for the development of improved serodiagnostic reagents.
Stroke Incidence and Mortality Trends in US Communities, 1987 to 2011 (2014)

In a multicenter cohort of black and white adults in US communities, stroke incidence and mortality rates decreased from 1987 to 2011. The decreases varied across age groups, but were similar across sex and race, showing that improvements in stroke incidence and outcome continued to 2011.
Design, Fabrication, and Testing of 10 MJ Composite Flywheel Energy Storage Rotors (1998)

Flywheel energy storage systems employing high speed composite flywheels and advanced electric motor/generators are being evaluated by the Department of Defense (DoD), NASA [1], and firms [2,3] to replace electrochemical battery banks in satellites and manned space applications.Flywheel energy storage systems can provide extended operating life and significant reduction in weight and volume compared to conventional electrochemical systems.In addition, flywheels can provide momentum or reaction wheel functions for attitude control.This paper describes the design, fabrication, and spin testing of two 10 MJ composite flywheel energy storage rotors.To achieve the demonstrated energy density of greater than 310 kJ/kg in a volume of less than 0.05 m 3 , the rotors utilize flexible composite arbors to connect a composite rim to a metallic shaft, resulting in compact, lightweight, high energy density structures.The paper also describes the finite element stress and rotordynamics analyses, along with a description of the fabrication and assembly techniques used in the construction of the rotor.A description of the experimental setup and a discussion of spin testing of the rotors up to 45,000 rpm (965 m/s tip speed) are also presented.Accurate measurements of rotor centrifugal growth made with laser triangulation sensors confirmed predicted strains of greater than 1.2% in the composite rim.Due to the weight penalty associated with flywheel designs requiring containment structures, there is a strong need to develop flywheel systems which operate safely in space, preferably without dedicated containment structures.A future paper will describe results of a 28,600 rpm composite rotor burst test performed in a containment structure as a step towards understanding composite rotor failure modes.