gebhart/patrepeval huggingface dataset:
Alterações cardiovasculares e intracranianas promovidas pela buprenorfina em cães anestesiados com desflurano (2004)

Objetivou-se com a realização deste experimento, estudar possíveis alterações nas variáveis cardiovasculares e intracranianas promovidas pela buprenorfina, em cães anestesiados com desflurano. Para tanto, foram utilizados oito cães adultos, clinicamente saudáveis. A anestesia foi induzida com propofol (8 mg/kg IV) e em seguida os animais foram intubados com sonda orotraqueal de Magill, a qual foi conectada ao aparelho de anestesia volátil para administração de desflurano (1,5 CAM). Os animais foram mantidos sob ventilação controlada durante todo o período experimental. Após 20 minutos do posicionamento do cateter de pressão intracraniana (PIC), administrou-se buprenorfina (0,02 mg/kg IV). Foram avaliados: PIC; pressão de perfusão cerebral (PPC); FC; PAS, PAM e PAD; débito cardíaco (DC); pressão venosa central (PVC); e pressão da artéria pulmonar (PAP). As colheitas foram feitas nos seguintes momentos: M1 - 20 minutos após o posicionamento do cateter de PIC; M2 - 15 minutos após a administração do opióide; M3, M4 e M5 - de 15 em 15 minutos após M2. A avaliação estatística dos dados foi efetuada por meio de ANOVA seguida do Teste de Tukey (p<0,05). A PIC permaneceu estável durante todo o período experimental. Entretanto, registrou-se uma queda acentuada, estatisticamente significativa, da PPC após o M2. As variáveis cardiovasculares FC, PAS, PAM, PAD, DC e PAP, apresentaram redução significativa de seus valores após M2, mantendo-se estáveis no restante do período experimental. Quanto à PVC, o teste estatístico não registrou alterações significativas. Assim, pôde-se concluir que a buprenorfina não interferiu na PIC. Entretanto, a queda dos índices cardiovasculares, especialmente da PAM, determinada pela administração do opióide, causa redução da PPC em cães anestesiados com desflurano.
Effect of Interphase Mass Transfer on Product Selectivity in Liquid-Phase Paraffin Chlorination (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of Interphase Mass Transfer on Product Selectivity in Liquid-Phase Paraffin ChlorinationMichael P. Ramage and Roger E. EckertCite this: Ind. Eng. Chem. Process Des. Dev. 1973, 12, 3, 248–254Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://doi.org/10.1021/i260047a007RIGHTS & PERMISSIONSArticle Views39Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (848 KB) Get e-Alerts
Synthesis of Potential Anticancer Agents. XVII. Preparation of 9-(Substituted-cycloaliphatic)-purines<sup>2</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Potential Anticancer Agents. XVII. Preparation of 9-(Substituted-cycloaliphatic)-purines2Howard J. Schaeffer and Richard D. Weimar Jr.Cite this: J. Am. Chem. Soc. 1959, 81, 1, 197–201Publication Date (Print):January 1, 1959Publication History Published online1 May 2002Published inissue 1 January 1959https://pubs.acs.org/doi/10.1021/ja01510a045https://doi.org/10.1021/ja01510a045research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Friction Characteristics of Hardfacing Materials in High Temperature Sodium (1980)

Friction and self-welding tests were conducted on several materials used for the contacting and sliding components of a sodium cooled fast breeder reactor. In the present study, the friction and self-welding characteristics of each material were evaluated through measuring the kinetic and breakaway friction coefficients. The influence of oscillating rotation and vertical reciprocating motion on the friction mode was also investigated.The results obtained are as follows:(1) Colmonoy No. 6, the nickel base hardfacing alloy, indicated the lowest kinetic friction coefficient of all the materials in the present study. Also, Cr3C2/Ni-Cr material prepared by a detonation gun showed the most stable friction behavior.(2) The breakaway friction coefficient of each material was dependent upon dwelling time in a sodium environment.(3) The friction behavior of Cr3C2/Ni-Cr material was obviously related with the finishing roughness of the friction surface. It was anticipated that nichrome material as the binder of the chrome carbide diffused and exuded to the friction surface by sliding in sodium.(4) The friction coefficient in sliding mode of vertical reciprocating was lower than that of oscillating rotation.
The Phosphorylated Form of the ORF3 Protein of Hepatitis E Virus Interacts with Its Non-glycosylated Form of the Major Capsid Protein, ORF2 (2002)

Hepatitis E virus (HEV) is a human RNA virus containing three open reading frames. Of these, ORF1 encodes the viral nonstructural polyprotein; ORF2 encodes the major capsid protein, which exists in a glycosylated and non-glycosylated form; and ORF3 codes for a phosphoprotein of undefined function. Using fluorescence-based colocalization, yeast two-hybrid experiments, transiently transfected COS-1 cell co-immunoprecipitation, and cell-free coupled transcription-translation techniques, we have shown that the ORF3 protein interacts with the ORF2 protein. The domains involved in this ORF2-ORF3 association have been identified and mapped. Our deletion analysis showed that a 25-amino acid region (residues 57-81) of the ORF3 protein is required for this interaction. Using a Mexican HEV isolate, site-directed mutagenesis of ORF3, and a phosphatase digestion assay, we showed that the ORF2-ORF3 interaction is dependent upon the phosphorylation at Ser(80) of ORF3. Finally, using COS-1 cell immunoprecipitation experiments, we found that the phosphorylated ORF3 protein preferentially interacts with the non-glycosylated ORF2 protein. These findings were confirmed using tunicamycin inhibition, point mutants, and deletion mutants expressing only non-glycosylated ORF2. ORF3 maps in the structural region of the HEV genome and now interacts with the major capsid protein, ORF2, in a post-translational modification-dependent manner. Such an interaction of ORF2 with ORF3 suggests a possible well regulated role for ORF3 in HEV structural assembly.
Fecal Excretion of Greek Strains of Hepatitis A Virus in Patients with Hepatitis A and in Experimentally Infected Chimpanzees (1986)

The presence of hepatitis A virus (HAV) in stool samples was determined in 36 children (mean age, 8.9 years) and 38 adults (mean age, 19.9 years) with acute type A hepatitis. Three stool samples, taken on admission and thereafter at three-to-five-day intervals, were collected from each patient. The first day of dark urine was considered to be the onset of illness. Molecular hybridization of cloned HAV cDNA to fecal extracts was used to detect HAV RNA; radioimmunoassay was used to detect HAV antigen. In all of the samples tested, HAV RNA was detected significantly more frequently than HAV antigen (28.4% vs. 8.1%, P less than .001). HAV RNA was detected with equal frequency in both children and adults during the first week of illness. However, HAV RNA was detected more frequently in children than in adults during the second week of illness (45.7% vs. 18.9%, P less than .05). Among patients with HAV RNA, detection in multiple samples was more frequent in children than in adults (38.9% vs. 7.9%, P less than .01), especially among males.
Piroxicam Treatment of Il-10-Deficient Mice Enhances Colonic Epithelial Apoptosis and Mucosal Exposure to Intestinal Bacteria (2005)

Treatment with the nonsteroidal anti-inflammatory drugs piroxicam or sulindac was recently shown to accelerate the development of colitis in interleukin (IL)-10-deficient (IL-10) mice. Although NSAIDs have been hypothesized to decrease the barrier function of the intestinal epithelium, the mechanism by which this accelerates colitis in IL-10 mice is not well understood. In this study, the effects of piroxicam on the colonic mucosa of IL-10 C57BL/6 mice were evaluated histologically. The effect of piroxicam on intestinal epithelial cells in vitro was assessed using colorimetric and fluorescent assays for cell viability and apoptotic cell death. Interactions of intestinal bacteria with the colonic mucosa were evaluated by rRNA-directed fluorescence in situ hybridization. In vivo treatment of C57BL/6 IL-10 mice with oral piroxicam markedly enhanced apoptosis of colonic epithelium and resulted in focal erosion of the mucosal surface, enhanced bacterial adhesion and invasion, and accelerated the development of colitis. In vitro, piroxicam induced apoptosis of CT26 murine intestinal epithelial cells in a dose-dependent fashion. Piroxicam-induced apoptosis of CT26 cells could not be prevented by addition of exogenous IL-10; however, IL-10 did significantly enhance their rate of proliferation. Thus, exposure to piroxicam enhances intestinal epithelial apoptosis both in vitro and in vivo and facilitates adhesion and invasion of intestinal bacteria into mucosal tissues in vivo. The role of IL-10 in this process requires further study. These studies support the hypothesis that increased exposure of mucosal cells to intestinal bacteria may lead to development of intestinal inflammation in IL-10 or other genetically susceptible individuals.
Using optical coherent tomography in endoscopy (2009)

This article shows that it is expedient to use optical coherent tomography (OCT) in endoscopic studies by means of video endoscopic complexes to diagnose the early stages of cancer of the gastrointestinal tract. The principle of OCT is described, and a theoretical basis is provided for signal-conversion processes in the light-source-patient-photodetector system, confirming the efficacy of the OCT method. A description is given of experimental samples of a video endoscopic complex that use the OCT method, their operating principles, and the results obtained when they are used in medical practice.
1717: The Bladder Trigone is not a Wolffian Duct Remnant (2004)

You have accessJournal of UrologyDiscussed Poster,Wednesday, May 12, 2004,8:00 am - 12:00 pm1 Apr 20041717: The Bladder Trigone is not a Wolffian Duct Remnant Preston C. Sprenkle, Ekatherina Batourina, Sheaumei Tsai, Sarah M. Lambert, Neal Paragas, Kenneth I. Glassberg, Terry W. Hensle, and Cathy L. Mendelsohn Preston C. SprenklePreston C. Sprenkle More articles by this author , Ekatherina BatourinaEkatherina Batourina More articles by this author , Sheaumei TsaiSheaumei Tsai More articles by this author , Sarah M. LambertSarah M. Lambert More articles by this author , Neal ParagasNeal Paragas More articles by this author , Kenneth I. GlassbergKenneth I. Glassberg More articles by this author , Terry W. HensleTerry W. Hensle More articles by this author , and Cathy L. MendelsohnCathy L. Mendelsohn More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38909-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1717: The Bladder Trigone is not a Wolffian Duct Remnant." The Journal of Urology, 171(4S), p. 454 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 454 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Preston C. Sprenkle More articles by this author Ekatherina Batourina More articles by this author Sheaumei Tsai More articles by this author Sarah M. Lambert More articles by this author Neal Paragas More articles by this author Kenneth I. Glassberg More articles by this author Terry W. Hensle More articles by this author Cathy L. Mendelsohn More articles by this author Expand All Advertisement PDF downloadLoading ...
<i>In vitro</i>pharmacological characterization of a novel p38α (MAPK14) inhibitor designed for inhaled delivery (2016)

<b>Introduction</b> The p38α (MAPK14) is a kinase which regulates the production of key inflammatory mediators, including TNF-α and IL-8. To date, losmapimod is the most advanced p38α inhibitor currently progressed to clinical trials in COPD in an oral formulation. Inhaled drug delivery may achieve pharmacologically relevant lung concentrations with limited systemic exposure. We report the <i>in vitro</i> characterization of a novel p38α inhibitor specifically designed for inhaled administration. <b>Methods and Results</b> CHI-91040 proved to be >100-fold more potent in inhibiting p38α (IC<sub>50</sub>= 0.14 nM) and p38β (IC<sub>50</sub>= 0.14 nM) enzymatic activity than losmapimod (IC<sub>50</sub> values of 23 and 138 nM, respectively). CHI-91040 showed a >6,000-fold selectivity against p38γ, p38δ as well as against a panel of more than 400 human kinases. By using surface plasmon resonance to measure dissociation enzyme kinetics, the calculated t<sub>1/2</sub> of CHI-91040 was >24h, suggesting a potential long duration of action. In human peripheral blood mononuclear cells, CHI-91040 inhibited (IC<sub>50</sub>=1.0) LPS-stimulated TNF-α release more potently than losmapimod (IC<sub>50</sub>=27 nM). CHI-91040 also inhibited LPS-evoked release of TNF-a from rat alveolar macrophages (IC<sub>50</sub>=3.5 nM), IL-8 release from BEAS-2B airway epithelial cells (IC<sub>50</sub>=1.2 nM) and IL-8 release induced by cigarette smoke extract in bronchial smooth muscle cells (IC<sub>50</sub>=1.1 nM). <b>Conclusions</b> CHI-91040, which is currently undergoing clinical evaluation as a novel treatment for COPD and/or severe asthma, shows a robust anti-inflammatory profile which correlates with its inhibitory potency against p38α.
Two rare indium-based porous metal–metalloporphyrin frameworks exhibiting interesting CO2 uptake (2013)

Two rare indium-based porous metal–metalloporphyrin frameworks (MMPFs), MMPF-7 and MMPF-8, were constructed by self-assembly of In(III) and two custom-designed porphyrin–tetracarboxylate ligands. MMPF-7 and MMPF-8 possess the pts topology and exhibit interesting CO2 adsorption properties.
Look Like Me: Matching Robot Personality via Gaze to Increase Motivation (2015)

International audience
A Lowland Maya Long Count/Gregorian Conversion Computer Program (1975)

A Fortran computer program is presented which converts Lowland Maya Long Count dates into their equivalent Gregorian dates, and the reverse, for the period post-A.D. 100. The program uses the Modified Thompson 2 Correlation Constant, but other Correlation Constants can also be employed. This program does not offer a new correlation hypothesis.
Assessment of an optical flow field-based polyp detector for CT colonography (2005)

Most current computer-aided detection (CAD) algorithms for the fully automatic detection of colonic polyps from 3D CT data suffer from high false positive rates. We developed and evaluated a post-processing algorithm to decrease the false positive rate of such a method. Our method attempts to model the way a radiologist recognizes a polyp while scrolling a cross-sectional plane through 3D CT data by quantifying the change in location of the edges in the 2D plane. It uses a classifier for identification based on the Mahalanobis distance. The new method increased the ROC curve area from 0.89 to 0.98 (an increase from 34.5% to 85.0% in specificity for 100% sensitivity) in a population of 8 patients.
Adaptation of sympatric <i>Achromatium</i> spp. to different redox conditions as a mechanism for coexistence of functionally similar sulphur bacteria (2004)

Changes in the abundance of sympatric Achromatium spp. in response to the artificial manipulation of redox conditions in sediment microcosms was determined by fluorescence in situ hybridization (FISH). Adaptation to different redox conditions was shown to be one mechanism that supported the coexistence of functionally similar Achromatium spp. In sediment microcosms, in which the overlying water was oxygenated, Achromatium community size and composition remained unchanged over time. However, imposition of anoxic conditions induced changes in community structure. Anoxia caused a reduction in the relative abundance of Achromatium sp. RY8 (72 +/- 4% to 49 +/- 2%) and an increase in Achromatium sp. RY5 (19 +/- 5% to 32 +/- 3%) and a newly identified Achromatium sp., RYKS (14 +/- 4% to 27 +/- 2%). In anoxic microcosms supplemented with a single addition of nitrate at different initial concentrations the relative decline in Achromatium sp. RY8 was dependent on the initial nitrate concentration. In these experiments nitrate was rapidly removed. In contrast, when high levels of nitrate were maintained by periodic replacement of the overlying water with nitrate supplemented anoxic water, the composition of the Achromatium community remained stable over time. This suggested that all of the coexisting Achromatium spp. are obligate or facultative anaerobes, but, Achromatium sp. RY8 was more sensitive to sediment redox conditions than the other Achromatium species. Given the heterogeneous nature of sedimentary environments, redox-related niche differentiation may promote coexistence of sympatric Achromatium spp.
Optimal control of a regional power microgrid network driven by wind and solar energy (2011)

In this paper, a model to support optimal decisions in a network of microgrids is formalized as an original discrete and centralized problem defined here as cooperative network of smart power grids problem. The control variables are the instantaneous flows of power in the network of microgrids, which can be obtained from the solution of a linear quadratic Gaussian (LQG) problem on a fixed time horizon. The state is represented by the energy stored in each microgrid. The goal is to minimize the variations of the energy stored in each storage device from a reference value, as well as to minimize the exchange of power between the microgrids. An application of the model is proposed taking into account wind and solar data in three sites in Liguria region (Castellari, Capo Vado and Savona). It is assumed that each microgrid is composed by a renewable hybrid energy system, a cluster of 100 households and a storage device.
Expression of the CD 15 antigen is a marker of cellular differentiation in cervical intra‐epithelial neoplasia (CIN) (1988)

The CD 15 antigen (3-fucosyl N-acetyllactosamine), present on the outer cell membrane of cervical squamous epithelial cells, is recognized by the monoclonal antibody MC2, which is similar to several commercially available antibodies. Staining sections of cervical biopsies with MC2 clearly demonstrates the zone of supra-basal differentiated cells in the normal squamous epithelium. Staining with MC2 also demonstrates the diminished proportion of this zone occurring with grades of CIN, reflecting progressive de-differentiation of the epithelium. In immature squamous metaplastic epithelium, absence of cytoplasmic differentiation is reflected by lack of staining. As expression of the CD 15 antigen by cervical squamous cells mirrors cytoplasmic maturity and is a marker of cellular differentiation, staining colposcopic biopsies with MC2 may aid the routine histopathological grading of CIN. A comparison is made between the staining pattern observed using MC2 with that of two commercially available antibodies (Leu M1 and Dako M1), and a possible role for the CD 15 antigen in cellular adhesion in squamous mucosae is discussed.
MASS-MOVEMENT ACTIVITY: AN ILLUSTRATION OF DIFFERING RESPONSES TO GROUNDWATER CONDITIONS FROM TWO SITES IN NORTHERN IRELAND (1977)

Field investigation of slope failure in north-eastern Ireland, at Kilkeel, Co. Down, and Minnis North, Co. Antrim, suggests that groundwater level is an important factor influencing the incidence of failure. However, the pattern of mass-movement in slopes of glacial origin at Kilkeel compared to the Lias clays of Minnis North implies that different types of mass-movement demonstrate different responses to general groundwater conditions. These observations indicate that the traditional formulas used by geomorphologists for soil mechanics problems may need to be modified with respect to the observed character of groundwater conditions.
The von Willebrand factor-binding protein (vWbp) of<i>Staphylococcus aureus</i>is a coagulase (2004)

Staphylococcus aureus encodes a secreted von Willebrand factor-binding protein (vWbp) of 482 amino acids. The N-terminal part of this protein is homologous to staphylocoagulase and therefore we investigated whether vWbp has coagulating activity. Recombinant vWbp was shown to coagulate human and porcine plasma efficiently, but was less active against plasma from other species. The coagulation efficiency was concentration dependent, and could be inhibited by specific antibodies against vWbp. Furthermore, the species-specific coagulation by vWbp depended on the interaction with prothrombin. This interaction also resulted in specific cleavage of vWbp, releasing the C-terminal part from the coagulating domain.
Multi‐objective shape segmentation and labeling (2009)

Abstract Shape segmentations designed for different applications show significant variation in the composition of their parts. In this paper, we introduce the segmentation and labeling of shape based on the simultaneous optimization of multiple heterogenous objectives that capture application‐specific segmentation criteria. We present a number of efficient objective functions that capture useful shape adjectives (compact, flat, narrow, perpendicular, etc. ) Segmentation descriptions within our framework combine multiple such objective functions with optional labels to define each part. The optimization problem is simplified by proposing weighted Voronoi partitioning as a compact and continuous parametrization of spatially embedded shape segmentations. Separation of spatially close but geodesically distant parts is made possible using multi‐dimensional scaling prior to Voronoi partitioning. Optimization begins with an initial segmentation found using the centroids of a k‐means clustering of surface elements. This partition is automatically labeled to optimize heterogeneous part objectives and the Voronoi centers and their weights optimized using Generalized Pattern Search. We illustrate our framework using several diverse segmentation applications: consistent segmentations with semantic labels, bounding volume hierarchies for path tracing, and automatic rig and clothing transfer between animation characters.