gebhart/patrepeval huggingface dataset:
Sarcolemmal calcium transport and drug action. (1980)

Sarcolemmal-rich microsomal fractions were isolated from rabbit ventricular muscle differential centrifugation and discontinuous sucrose gradient techniques. The fractions were characterized in terms of calcium binding, enzymatic activity, gel electrophoresis, and ultrastructure. Calcium binding and the initial rates of binding were assayed using 45Ca2+ and Millipore filtration in a reaction mixture containing 100 mM KCl, 5 mM MgCl2, 50 mM Tris, Ca2+, and either nitrilotriacetic acid (NTA) or adenosine triphosphate (ATP). The free calcium concentrations of the media were calculated using an ion complexes-in-solutions computer program with either an NTA or an ATP calcium buffering system. The Ca2+-accumulating activity of these sarcolemmal preparations involved more than one type of binding site. One type of site appeared to be rapidly saturable; calcium accumulation at these sites was energy independent. The second type of site required ATP for binding. Calcium accumulation at both sites was temperature and pH sensitive. These results are discussed in terms of the interaction of inotropically active drugs with the different types of binding sites.
Multifrequency sources of quantum correlated photon pairs on‐chip: a path toward integrated Quantum Frequency Combs (2016)

Abstract Recent developments in quantum photonics have initiated the process of bringing photonic‐quantumbased systems out‐of‐the‐lab and into real‐world applications. As an example, devices to enable the exchange of a cryptographic key secured by the laws of quantum mechanics are already commercially available. In order to further boost this process, the next step is to transfer the results achieved by means of bulky and expensive setups into miniaturized and affordable devices. Integrated quantum photonics is exactly addressing this issue. In this paper, we briefly review the most recent advancements in the generation of quantum states of light on‐chip. In particular, we focus on optical microcavities, as they can offer a solution to the problem of low efficiency that is characteristic of the materials typically used in integrated platforms. In addition, we show that specifically designed microcavities can also offer further advantages, such as compatibility with telecom standards (for exploiting existing fibre networks) and quantum memories (necessary to extend the communication distance), as well as giving a longitudinal multimode character for larger information transfer and processing. This last property (i.e., the increased dimensionality of the photon quantum state) is achieved through the ability to generate multiple photon pairs on a frequency comb, corresponding to the microcavity resonances. Further achievements include the possibility of fully exploiting the polarization degree of freedom, even for integrated devices. These results pave the way for the generation of integrated quantum frequency combs that, in turn, may find important applications toward the realization of a compact quantum‐computing platform.
Mass Soectrometric Analysis of Germanium (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMass Soectrometric Analysis of GermaniumR. E. HonigCite this: Anal. Chem. 1953, 25, 10, 1530–1535Publication Date (Print):October 1, 1953Publication History Published online1 May 2002Published inissue 1 October 1953https://doi.org/10.1021/ac60082a032Request reuse permissionsArticle Views56Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (694 KB) Get e-Alertsclose Get e-Alerts
Pteridines. III. Synthesis of Some Ketones, Carbinols, and N-Oxides (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPteridines. III. Synthesis of Some Ketones, Carbinols, and N-OxidesIrwin J. Pachter, Piroska E. Nemeth, and Anthony J. VillaniCite this: J. Org. Chem. 1963, 28, 5, 1197–1202Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://pubs.acs.org/doi/10.1021/jo01040a008https://doi.org/10.1021/jo01040a008research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A new actuation approach for human friendly robot design (2004)

Many successful robotic manipulator designs have been introduced. However, there remains the challenge of designing a manipulator that possesses the inherent safety characteristics necessary for human-centered robotics. In this paper, we present a new actuation approach that has the requisite characteristics for inherent safety while maintaining the performance expected of modern designs. By drastically reducing the effective impedance of the manipulator while maintaining high frequency torque capability, we show that the competing design requirements of performance and safety can be successfully integrated into a single manipulation system.
Is There a Role for Drug‐Eluting Balloons in Treatment of Acute Coronary Syndromes? (2014)

Due to the introduction of the coronary care unit, and with the successful pharmacological and later percutaneous reperfusion of occluded coronary arteries, mortality rates in patients with an acute coronary syndrome have reduced considerably. However, reinterventions because of restenosis in the treated segment have hampered outcomes. With the introduction of drug-eluting stents, fewer reinterventions are needed, with a more effective inhibition of neointimal hyperplasia than with bare metal stents. Nevertheless, safety concerns regarding the use of drug-eluting stents in acute coronary syndrome patients, especially the associated increased risk of late stent thrombosis, due to delayed neo-endothelialization, and chronic inflammation with late-acquired malapposition remain a drawback. Consequently, the search for a device that can reduce the number of reinterventions, while sustaining the safety profile of a bare metal stent, is ongoing. A relatively new device is the drug-eluting balloon which is an angioplasty balloon with a drug coating, with antirestenotic properties. By delivering the antirestenotic drug during short drug-eluting balloon dilations, reinterventions might be reduced without a sustained drug release as for drug-eluting stents. By avoiding ongoing drug release and chronic inflammation due to the absence of polymers, the risk of stent thrombosis could potentially be reduced with drug-eluting balloonswhile at the same time limiting the restenosis rates.
Complexes of peroxy radical with transition metal ions (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplexes of peroxy radical with transition metal ionsA. Samuni and Gideon CzapskiCite this: J. Phys. Chem. 1970, 74, 26, 4592–4594Publication Date (Print):December 1, 1970Publication History Published online1 May 2002Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/j100720a024https://doi.org/10.1021/j100720a024research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Concentrations of cysteinyl leukotrienes in urine and bronchoalveolar lavage fluid of cats with experimentally induced asthma (2003)

Although LTs were readily detectable in urine, no significant increases in urinary LT concentrations were detected after challenge in allergen-sensitized cats. Spot testing of urinary LT concentrations appears to have no clinical benefit for use in monitoring the inflammatory asthmatic state in cats. The possibility that cysteinyl LTs bind effectively to their target receptors in BALF and, thus, decrease free LT concentrations deserves further study.
WDM transmission system using dispersion slope management (1998)

In wavelength division multiplexing (WDM) transmission systems, it is a problem that the transmission characteristics are degraded due to the fiber nonlinear effects. These nonlinear effects are caused by the pulse collision due to the group velocity difference between different channels. In this paper, a novel WDM transmission system with the dispersion slope management is proposed. The system manages not only dispersion but also dispersion slope and group velocity differences to suppress the third order dispersion and nonlinear effects. Our numerical results shows that the proposed system can suppress both of them and has good characteristics in long haul transmission.
Vascular Vasopressin Receptors Mediate Inhibition of Atrial Natriuretic Factor (ANF)-Induced cGMP Accumulation (1986)

(Department of Molecular Pharmacology, Smith Kline & French Laboratories, Philadelphia, PA, U.S.A.).
ECG variability contour—a reference for evaluating the significance of amplitude ECG changes in two states (2008)

The sensitivity of the standard 12-lead ECG for detecting myocardial ischemia is low perhaps because in the printed ECG only three to five complexes are examined, only absolute amplitude (voltage) criteria are used, and amplitude changes are sought only in the ST segment and T wave regions. A computerized method is proposed for evaluating the significance of ECG amplitude changes detected in one state compared with another (e.g. rest and stress). Amplitude changes were considered significant if they were consistently greater than the 'ECG variability contour' (EVC), which is a graphic measure introduced in this study, calculated from the reference ECG signal. Rest and stress simulation ECG (SECG) were constructed. Mean rest SECG complex was subtracted from rest and stress SECG complexes to result in rest and stress residue matrices, respectively. The percentage of the normalized cumulative sum (NCS) of the residues during stress (and rest) lying outside the EVC served as a measure for evaluating ECG changes associated with stress (and rest). With this method, amplitude changes of magnitude similar to that of the noise, which were difficult to detect visually, were easily detected and accurately allocated to the component of the ECG complex where they occurred. The proposed method may be useful in cases where amplitude changes are too subtle and thus overlooked or not detected by the standard examination of three to five complexes or underestimated due to unmet clinical (voltage) criteria, or occur in ECG components that are not regularly examined.
<b>Infrared Spectra of Aqueous Solutions. IV. Glycine and Glycine Peptides</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared Spectra of Aqueous Solutions. IV. Glycine and Glycine PeptidesMyo K. Kim and Arthur E. MartellCite this: J. Am. Chem. Soc. 1963, 85, 20, 3080–3083Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ja00903a005https://doi.org/10.1021/ja00903a005research-articleACS PublicationsRequest reuse permissionsArticle Views461Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Model Calculation of the Magnetic Induction Generated by Magnetic Nanoparticles Flowing Into a Microfluidic System: Performance Analysis of the Detection (2013)

This paper presents a mathematical model of the detection of the magnetic nanoparticles (MNPs) flowing into a microchannel. To validate the model, the experimental measurements were performed using a ferrofluid and a giant magneto impedance microwire made up of CoFeSiBNb alloy as a sensor. The good agreement between theory and measurement implies the possibility of using the numerical simulation to analyze the system performance for the MNPs detection. In addition, a model calculation was performed, which evaluates the optimal signal-to-noise ratio of the detection system as a function of its main parameters and according to the magnetic induction induced by the MNPs.
Clinical activity of pembrolizumab (P) in undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated/pleomorphic liposarcoma (LPS): Final results of SARC028 expansion cohorts. (2019)

11015 Background: Immune checkpoint inhibitors have demonstrated activity in multiple tumor types but their activity in soft tissue sarcomas remains limited. In the multicenter phase II study, SARC028, the anti-PD-1 antibody, P demonstrated objective responses that were largely restricted to UPS and LPS subtypes. We now report outcomes from 2 expansion cohorts of SARC 028 in advanced UPS and LPS. Methods: To further confirm the clinical activity of P in UPS and LPS, we enrolled an additional 30 pts in each of 2 expansion cohorts for a total of 40 UPS and 40 LPS pts. Primary endpoint was investigator-assessed response by RECIST v1.1. Secondary endpoints were safety, progression-free survival (PFS), 12-week PFS rate, and overall survival (OS). An ORR of 25% was considered clinically meaningful and < 10% was considered to show lack of efficacy. P was to be considered a success if 8 or more of 40 enrolled patients had a PR or better (1-sided α = 0.042, 82% power). Pts age ≥18 with advanced, refractory UPS or LPS received 200 mg of P IV every 3 weeks until progression or unacceptable toxicity. Results: Preliminary results from the first 10 pts in each of the UPS and LPS cohorts have been reported. We now present summary data after enrolling an additional 30 pts in each cohort. The ORR in the UPS cohort was 23% (9/40), with an additional 5/30 PRs observed in the expansion cohort (total 2 CRs, 7 PRs). In the LPS cohort, the ORR was 10% (4/39 evaluable pts), with an additional 2/30 PRs observed (total 4 PRs). Median PFS for the UPS group was 3 months [95% CI: 2, 5] and 2 months [95% CI: 2, 4] for the LPS group. 12-week PFS rate was 50% in UPS [95% CI: 35, 65] and 44% in LPS [95% CI: 28, 60]. The UPS group had a median OS of 12 months [95% CI: 7, 34] and 13 months [95% CI: 8, NR] for the LPS group. P was well tolerated with no unexpected toxicities. Conclusions: The UPS cohort achieved its primary endpoint, however the activity of P in UPS deserves further evaluation in a randomized study. The activity of P was not confirmed in the LPS cohort. Ongoing biomarker analyses may direct better patient selection and guide future combination strategies. Clinical trial information: NCT02301039.
Principles of Computer System Design for Stereo Perception (2018)

This paper presents principles for designing a computer system that supports stereo perception for an autonomous, mobile robot. These principles aid the engineer in selecting a CPU and network bus to maintain an acceptable level of robotic capability without needlessly large performance margins, which can result in excessive system power consumption. A series of configuration equations are presented that describe relationships between important system parameters such as CPU clock speed, network communication latency, computer power consumption, robot response distance, robot velocity and stereo camera parameters. Configuration equations are intended to improve the engineer’s ability to make trade-off decisions early in the design process. An application of these principles on an existing autonomous mobile robot, Hyperion, are presented both as an example and to outline future work.
Building trust in public institutions? good governance and anti-corruption in Bosnia-Herzegovina (2006)

Abstract Ten years after Dayton corruption and good governance rather than ethnic nationalism are widely alleged to be the central problems facing international attempts to construct capable and legitimate Bosnian state institutions. Political corruption substitutes private interests for public interests and in so doing undermines trust in public institutions, which depends on the fair and equal treatment of all citizens. In prioritizing anti-corruption and good governance initiatives, the international administration in Bosnia reflects an increasing international focus on these aspects as crucial to state-building initiatives. This paper considers the anti-corruption policies developed in the past decade and assesses the extent to which anti-corruption and good governance practices, developed by Bosnia's international administrators, have, in fact, rebuilt trust in Bosnia's public institutions.
Hypothetical Proposal on Ground-Flash Points under Winter Thundercloud in Hokuriku District (1991)

Simultaneous observations of the electric field intensity on the ground as well as optical observations of lightning flashes by VTR cameras have been performed in each one month from November to December for these five years in Kahoku-gata, a reclaimed flat land territory (4×5km in E-W and N-S directions) located in the northern suburbs of Kanazawa in winter. Polarity and approximate intensity of the electric field intensity on the ground have been obtained from continuous observation of the point corona discharge current. Regional distribution of the electric field is presumed by a graphical method on the basis of the time variations of those two quantities observed at six sites in the territory. On the other hand, lightning discharges occurred in the same territory have been recorded by several VTR cameras from two directions, three cameras observing from the east at Ishikawa College of Technology, other two from the north at Unoke fire department. These cameras were continuously operated for eight hours when thundercloud is forecasted to come over there.Finally, the eleven accurate stroke points of the cloud-to-ground discharges were determined on the map. And it is found that the eleven stroke points are all located within the narrow band of ±1 km width including the boundary line between the positive and the negative domains of the electric field on the ground.
Changes in neuronal response to ischemia in retinas with genetic alterations of somatostatin receptor expression (2007)

Ischemia is a primary cause of neuronal death in retinal diseases. The repertoire of expressed transmitter receptors would determine the neurons' responses to ischemic damage, and peptidergic receptors may be involved. With a new in vitro model of the ischemic mouse retina, we investigated whether an altered expression of somatostatin receptors could modulate retinal responses to ischemia. We used retinas of somatostatin receptor 1 (sst(1)) knock out (KO) mice, where sst(2) are over-expressed and over-functional, and of sst(2) KO mice. TUNEL analysis of ischemic retinas showed a marked reduction of cell death in sst(1) KO retinas, while there were no differences between wild-type (WT) and sst(2) KO retinas. In addition, caspase-3 mRNA expression was also reduced in sst(1) KO as compared to WT retinas. An immunohistochemical analysis demonstrated that different cell populations responded differently to the ischemic insult, and that the persistence of some immunohistochemical markers was greater in sst(1) KO than in WT or in sst(2) KO retinas. In particular, rod bipolar cell survival was markedly improved in sst(1) KO retinas, while it was dramatically decreased in sst(2) KO retinas. Furthermore, consistent with a role of glutamate excitotoxicity in ischemia-induced neuronal death, retinal glutamate release was observed to increase under ischemic conditions, but this increase was significantly reduced in sst(1) KO retinas. These observations demonstrate that an increased presence of functional sst(2) protects against retinal ischemia, thus implementing the background for the use of sst(2) analogs in therapies of retinal diseases such as glaucoma or diabetic retinopathy.