gebhart/patrepeval huggingface dataset:
Tetracaine attenuates irritancy without attenuating desensitization produced by intravesical resiniferatoxin in the rat (1994)

The irritancy of initial application of capsaicin and related substances limits their therapeutic potential as novel analgesics. The purpose of the present study was to determine whether the irritant properties of the potent, capsaicin-like compound resiniferatoxin (RTX) would be attenuated by pretreatment with a local anesthetic and to determine whether the local anesthetic had significant effects on RTX-induced desensitization of sensory afferents. A model of visceral nociception in which irritants are instilled directly into the bladder (intravesical, i.ves.) of awake, freely moving rats was used. The nociceptive response, abdominal licking (grooming) was scored for 15 min; locomotor activity was scored concurrently. Tetracaine (0.125-1.0%) attenuated the increases in abdominal licking produced by RTX (3.0 nmol) in a dose- and time-dependent manner. At high doses, tetracaine also suppressed locomotor activity. Thirty minutes and 24 h later, the same dose of RTX was administered again to assess development of desensitization of bladder sensory afferents. Rats that had been pretreated with saline showed decreases in licking behavior from the first to subsequent injections of RTX, indicating the development of desensitization. Tetracaine-pretreated rats showed equivalent or significantly greater decreases in licking behavior, suggesting that local anesthetic pretreatment either did not alter or enhanced development of desensitization to RTX. In a second experiment, tetracaine (0.25 or 0.5%) produced similar effects against a high dose of RTX (3.0 nmol), but did not consistently alter excitatory or desensitizing effects of a low dose of RTX (0.1 nmol).(ABSTRACT TRUNCATED AT 250 WORDS)
Next Generation Database Programming and Execution Environment. (2011)

The database research is always on the move. In order to integrate novel concepts, the significance of the database programmability aspect more and more increases. The programmability aspect focuses on internal components as well as on principle to push-down application logic to the database system. In this paper, we propose a novel database programming model and a corresponding database architecture framework enabling extensibility and a better integration of application code into DBMS. In detail, we present a scripting language pyDBL which is unified utilizable to implement physical database operators, query plans and even complete applications. We demonstrate the applicability of our approach in terms of a moderate performance overhead. 1.
A Diagrammatic Classification of Man-Machine System Displays (1964)

A diagram is developed which classifies man–machine system displays according to their complexity. This diagram aids in gaining a better understanding of display concepts and in adding to our knowledge of display design. Displays are categorized as elementary, intermediate, or complex, depending upon the complexity of instrumentation required for implementation. The elementary group contains the pursuit and compensatory types while the complex group contains the new contact analog and situation types. In the intermediate group are new predictor types which are useful when controlling sluggish dynamics. Several general guidelines regarding the design of displays are obtained from the display diagram. These guidelines aid in selecting those displays which may be suitable for a given man–machine control-system problem, thereby reducing the amount of display experimentation that must be performed.
Expanded tropism of Human Herpesvirus-8 (HHV-8) for hematopoietic-derived cells upon Kaposi's sarcoma (KS) development (1999)

Colombini, Sandra; Monini, Paolo; Stürzl, Michael; Goletti, Delia; Cafaro, Aurelio; Sgadari, Cecilia; Buttò, Stefano; Franco, Marina; Leone, Patrizia; Leone, Pasqualina; Melucci-Vigo, Gianna; Ascherl, Gudrun; Ramazzotti, Eric; Andreoni, Massimo; Rezza, Gianni; Yarchoan, Robert; Ensoli, Barbara Author Information
Diurnal Variations of Liver Folate Metabolism in Rats Maintained Under Controlled Feeding Schedules (1974)

Rats maintained under controlled feeding schedules exhibit daily rhythms of the enzyme activities involved in folate metabolism. Tetrahydrofolate dehydrogenase and serine hydroxymethyl transferase show only small variations in their activity in the range of the 24-hr cycle. The 5,10-CH2-H4folate dehydrogenase shows a peak of activity at 6 PM (18:00), while the 5,10-CH2-H4folate synthetase activity reaches its lowest level between 3:00 PM (15:00) and 3:00 AM (3:00). The liver content of folate coenzymes does not change significantly during the whole day.
Leukocyte perturbation associated with Fabry disease (2009)

Fabry disease is an X-linked lysosomal storage disorder of glycosphingolipid catabolism due to the deficient activity of the enzyme alpha-galactosidase A. The non-degraded substrate, mainly globotriaosylceramide (Galα1-4Galβ1-4Glcβ1-1Cer; Gb(3)) accumulates progressively in the lysosome of various cells. The aim of this work was to analyse changes in leukocyte subpopulations and surface markers and to determine whether Gb(3) is increased in leukocytes of patients with untreated and treated Fabry disease. Blood samples obtained from 22 male Fabry patients (11 untreated and 11 on enzyme replacement therapy) and 22 normal controls were subjected to flow cytometric analysis of Gb(3) intracellular content, leukocyte subpopulations and cell markers. Based on the fluorescence intensity of bound monoclonal antibody, and relative to normal control leukocytes, Gb(3) appeared significantly increased in lymphocytes (but not in monocytes or granulocytes) from patients with Fabry disease. A significantly higher percentage of lymphocytes and CD19(+) cells and a reduced proportion of monocytes, CD8(+) cells and myeloid dendritic cells were detected in samples from Fabry patients compared with normal controls. CD1d expression was significantly lower and MHC class II surface expression was significantly higher in monocytes from Fabry patients than in normal controls. As previously observed for other adhesion molecules, the expression of CD31 (PECAM) was higher in leukocytes from Fabry patients. In conclusion, the differences recorded in this study reveal a leukocyte perturbation associated with the disease state in Fabry patients, whereas some abnormalities are less marked in treated patients.
Human PLU-1 Has Transcriptional Repression Properties and Interacts with the Developmental Transcription Factors BF-1 and PAX9 (2003)

PLU-1 is a large (1544 amino acids) nuclear protein that is highly expressed in breast cancers and is proposed to function as a regulator of gene expression. A yeast two-hybrid screen using PLU-1 as bait has identified two unrelated PLU-1 interacting proteins, namely brain factor-1 (BF-1) and paired box 9 (PAX9), both of which are developmental transcription factors. BF-1 and PAX9 interact with PLU-1 via a novel conserved sequence motif (Ala-X-Ala-Ala-X-Val-Pro-X4-Val-Pro-X8-Pro, termed the VP motif), because deletion or site-directed mutagenesis of this motif in either protein abolishes PLU-1 interaction in vivo. In a reporter assay system, PLU-1 has potent transcriptional repression activity. BF-1 and PAX9 also represses transcription in the same assay, but co-expression of PLU-1 with BF-1 or PAX9 significantly enhances this repression. Mutation of the PLU-1 binding motifs in BF-1 and PAX9 abolishes the observed PLU-1 co-repression activity. These data support a role for PLU-1 acting as a transcriptional co-repressor of two unrelated developmental transcription factors. Because both BF-1 and PAX proteins interact with members of the groucho co-repressor family, it is plausible that PLU-1 has a role in groucho-mediated transcriptional repression.
Incidence of heparin-induced thrombocytopenia and therapeutical strategies in pediatric cardiac surgery (2004)

Objectives: Heparin-induced thrombocytopenia type II (HIT II) is a rare complication after cardiac surgery with the use of heparin for the coagulation management on the extracorporeal circulation (ECC). We sought to identify the incidence of HIT II in pediatric patients undergoing cardiac surgery and documented the differences in the therapeutical regimen.
Lip segmentation with the presence of beards (2004)

Lip image analysis has attracted much interest in recent years because some important speech information is contained in the shape and movement of the lip. To extract such information from the images, accurate and robust lip region segmentation is of vital importance. However, most of the current lip segmentation methods fail to provide accurate results if the person has a beard. We propose a "one object, multiple background" clustering method to solve the problem. Since the non-lip region becomes inhomogeneous in the presence of a beard, multiple background clusters can produce better fitting to a rather complex background region than a single cluster. Spatial information in terms of the physical distance towards the lip center is incorporated to enhance the differentiation between the lip and background region. Experimental results demonstrate that our algorithm provides accurate lip segmentation results for images with beards.
A Functional Hydrogenase Mimic Chemisorbed onto Fluorine‐Doped Tin Oxide Electrodes: A Strategy towards Water Splitting Devices (2017)

A diiron benzenedithiolate hydrogen-evolving catalyst immobilized onto fluorine-doped tin oxide (FTO) electrodes is prepared, characterized, and studied in the context of the development of water splitting devices based on molecular components. FTO was chosen as the preferred electrode material owing to its conductive properties and electrochemical stability. An FTO nanocrystalline layer is also used to greatly improve the surface area of commercially available FTO while preserving the properties of the material. Electrodes bearing a covalently anchored diiron catalyst are shown to be competent for electrocatalytic hydrogen evolution from acidic aqueous media at relatively low overpotential (500 mV) with a faradaic efficiency close to unity. Compared with bulk solution catalysts, the catalyst immobilized onto the electrode surface operates at roughly 160 mV lower overpotentials, yet with similar rates.
Design of an Object Faulting Persistent Smalltalk (1990)

We present an approach to supporting persistence in heap-based programming languages, called object faulting. By modifying the language run-time system, we provide the illusion of a large heap of objects, only some of which are actually resident in memory. When the run-time system detects a reference to the contents of a non-resident object, an object fault occurs, causing the object to be made resident. We discuss an implementation of these techniques for Smalltalk that uses the Mneme persistent object store as the underlying storage manager.
PLANAR GaAs SCHOTTKY BARRIER DIODES (1997)

GaAs Schottky barrier diodes continue to be heavily used in millimeter and submillimeter wavelength heterodyne receiver applications where cryogenic cooling is not an acceptable option. This is because the diode technology is well known, reliable, and yields acceptable sensitivities at room temperature. Planar GaAs mixer diodes can now replace the older whisker contacted diodes to at least 600 GHz, and THz devices are easily within grasp. This presentation will update the status of planar mixer diode technology at the University of Virginia. Recent developments include methods to reduce anode dimensions and parasitic shunt capacitance, fabrication of GaAs diodes on quartz substrates with integrated circuit elements, and fabrication of a diode pair with an integrated log-periodic antenna and separate diode biasing for subharmonic mixing. The paper will conclude with a summary of the status of mixer performance based on planar diodes and a discussion of the potential for THz mixers.
Inspection on Coal Chemical Industries in Europe and United States (1958)

昨年7月から3ヵ月間にわたる筆者の欧米視察旅行の報告で, イギリスの石炭関係の研究所および家庭燃料工業, ドイツのルール炭田とその化学土業, 米国の褐炭の貯蔵, 頁岩油の製造について述べている。
Colorimetric Method for Ester Content of Alcoholic Beverages (1971)

Abstract A colorimetric method for determination of esters in alcoholic products was studied for the effect of procedural variables. It is based on the quantitative reaction of esters with hydroxylamine in alkaline solution to form a hydroxamic acid which, upon acidification, forms a colored complex in the presence of Fe(III) ions. Mathematical data are presented to demonstrate that the colorimetric method is superior to the AOAC saponification method, 9.051-9.052, for comparing samples which contain widely differing ester compositions. The colorimetric method is rapid and requires a small sample.
The geology of the Saint Helens mining district of Washington (1912)

The St. Helens mining district of Washington embraces parts of T. 9 and ION., R
Making the most of your triple store (2013)

Triple stores implementing the RL profile of OWL 2 are becoming increasingly popular. In contrast to unrestricted OWL 2, the RL profile is known to enjoy favourable computational properties for query answering, and state-of-the-art RL reasoners such as OWLim and Oracle's native inference engine of Oracle Spatial and Graph have proved extremely successful in industry-scale applications. The expressive restrictions imposed by OWL 2 RL may, however, be problematical for some applications. In this paper, we propose novel techniques that allow us (in many cases) to compute exact query answers using an off-the-shelf RL reasoner, even when the ontology is outside the RL profile. Furthermore, in the cases where exact query answers cannot be computed, we can still compute both lower and upper bounds on the exact answers. These bounds allow us to estimate the degree of incompleteness of the RL reasoner on the given query, and to optimise the computation of exact answers using a fully-fledged OWL 2 reasoner. A preliminary evaluation using the RDF Semantic Graph feature in Oracle Database has shown very promising results with respect to both scalability and tightness of the bounds.
Heat exchange between a bouncing drop and a superhydrophobic substrate (2017)

The ability to enhance or limit heat transfer between a surface and impacting drops is important in applications ranging from industrial spray cooling to the thermal regulation of animals in cold rain. When these surfaces are micro/nanotextured and hydrophobic, or superhydrophobic, an impacting drop can spread and recoil over trapped air pockets so quickly that it can completely bounce off the surface. It is expected that this short contact time limits heat transfer; however, the amount of heat exchanged and precise role of various parameters, such as the drop size, are unknown. Here, we demonstrate that the amount of heat exchanged between a millimeter-sized water drop and a superhydrophobic surface will be orders of magnitude less when the drop bounces than when it sticks. Through a combination of experiments and theory, we show that the heat transfer process on superhydrophobic surfaces is independent of the trapped gas. Instead, we find that, for a given spreading factor, the small fraction of heat transferred is controlled by two dimensionless groupings of physical parameters: one that relates the thermal properties of the drop and bulk substrate and the other that characterizes the relative thermal, inertial, and capillary dynamics of the drop.
Differential glycosylation of asymmetric acetylcholinesterase forms in external and internal muscle membranes (1997)

Conference Article| August 01 1997 Differential glycosylation of asymmetric acetylcholinesterase forms in external and internal muscle membranes M. Teresa MORAL-NARANJO; M. Teresa MORAL-NARANJO 1Dpto. Bioquímica y Biología Molecular-A. Edif. Veterinaria, Univ. Murcia, Apdo. 4021, 30071, Murcia, Spain. E. mail: cevidal@fcu.um.es Search for other works by this author on: This Site PubMed Google Scholar Juan CABEZAS-HERRERA; Juan CABEZAS-HERRERA 1Dpto. Bioquímica y Biología Molecular-A. Edif. Veterinaria, Univ. Murcia, Apdo. 4021, 30071, Murcia, Spain. E. mail: cevidal@fcu.um.es Search for other works by this author on: This Site PubMed Google Scholar Francisco J. CAMPOY; Francisco J. CAMPOY 1Dpto. Bioquímica y Biología Molecular-A. Edif. Veterinaria, Univ. Murcia, Apdo. 4021, 30071, Murcia, Spain. E. mail: cevidal@fcu.um.es Search for other works by this author on: This Site PubMed Google Scholar Cecilio J. VIDAL Cecilio J. VIDAL 1Dpto. Bioquímica y Biología Molecular-A. Edif. Veterinaria, Univ. Murcia, Apdo. 4021, 30071, Murcia, Spain. E. mail: cevidal@fcu.um.es Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1997) 25 (3): 441S. https://doi.org/10.1042/bst025441s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation M. Teresa MORAL-NARANJO, Juan CABEZAS-HERRERA, Francisco J. CAMPOY, Cecilio J. VIDAL; Differential glycosylation of asymmetric acetylcholinesterase forms in external and internal muscle membranes. Biochem Soc Trans 1 August 1997; 25 (3): 441S. doi: https://doi.org/10.1042/bst025441s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
Distribution and Elimination of Polychlorinated Dibenzo-<i>p</i>-dioxins, Dibenzofurans, Biphenyls, and <i>p</i>,<i>p‘</i>-DDE in Tissues of Bald Eagles from the Upper Peninsula of Michigan (2002)

Liver, muscle, fat, kidney, and gall bladder of eight bald eagles (Haliaeetus leucocephalus) found dead in the Upper Peninsula of Michigan during 2000 were analyzed for the presence of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (including coplanar PCBs), p,p'-DDE, and hexachlorobenzene (HCB). Necropsy results showed that the birds suffered from peritonitis, bacterial infection, or trauma. Concentrations of PCDD/DFs in livers ranged from 23 to 4500 pg/g on a wet weight basis (wet wt), whereas the least concentrations were found in blood plasma of bald eagle nestlings (2.3-49 pg/g, wet wt). A maximum total PCB concentration of 280,000 ng/g, wet wt, was found in the liver of a dead bald eagle affected by peritonitis. The greatest concentrations of p,p'-DDE and HCB in eagle livers were 17,000 and 120 ng/g, wet wt, respectively. Eagles with elevated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or total PCB concentrations tended to have great TCDD/TCDF or PCB126/PCB77 ratios, hypothesized to be due to induction of cytochrome P450 enzymes and subsequent metabolism of TCDF and PCB77. Concentrations of TCDD toxic equivalents (TEQs) in the tissues of bald eagles exceeded the thresholds for toxicity in a few avian species. Non-ortho coplanar PCBs accounted for 68-88% of the total TEQs in bald eagle tissues. PCDDs and PCDFs collectively accounted for, on average, 17% of the total TEQs. On the basis of the analysis of a single gall bladder with bile, biliary excretion rates of PCDDs, PCDFs, and PCBs were estimated as 0.015-0.02% per day.
CAD-Based Modelling of Large Cryogenic Solid Propellant Motors (2006)

Cryogenic solid propulsion (CSP) uses chemical rocket propellant combinations with at least one frozen component in solid rocket motors. As a result, CSP combines the simplicity and reliability of conventional solid propulsion with the high Isp performance levels of cryogenic liquid propulsion. In the framework of research and development under German (DLR) and European (ESA) sponsorship, the general feasibility of CSP was successfully demonstrated. An experimental combustion chamber holding up to 1 kg of CSP propellants was built at AI: Aerospace Institute and recently hot fired successfully at Fraunhofer Institute for Chemical Technology. Selected hybrid CSP propellants in specific configurations show good burning behavior with a regression rate that lies in the range of conventional solid rocket propellants. Due to the required cryogenic infrastructure, CSP operation can only be cost efficient for a certain minimum stage size. Therefore, the main field of CSP application should refer to large boosters and first stages of heavy lift launch vehicles. In the frame of preparatory work, it was shown that launchers with CSP boosters or CSP lower stages can be compared performance-wise with ARIANE 5 type launchers using conventional solid propulsion. Green hybrid propellant combinations using frozen liquids like solid hydrogen peroxide (SHP) or solid oxygen (SOX) in combination with hydrocarbon polymers like polyethylene (PE) in solid rocket motors proved best for entering CSP technology development. The paper presents the main results of the CSP motor mass and performance modeling that was accomplished by means of CAD/CAE based methods considering major modifications required for CSP application in large solid rocket motors.
Prospective assessment of integrating the existing emergency medical system with automated external defibrillators fully operated by volunteers and laypersons for out-of-hospital cardiac arrest: the Brescia Early Defibrillation Study (BEDS) (2005)

Diffuse implementation of AEDs fully operated by trained volunteers and laypersons within a broad and unselected environment proved safe and was associated with a significantly higher long-term survival of CA victims.
Isolation and characterization of CAB-63, a novel calcium-binding protein. (1985)

A novel calcium-binding protein named CAB-63 (formerly called calregulin) has been purified from bovine liver 100,000 X g supernatant. The purified protein has been characterized with respect to its physical, chemical, and calcium-binding properties. It has an apparent molecular weight of 63,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and 55,000 by sedimentation equilibrium centrifugation under nondenaturing conditions. It is an asymmetric molecule with a frictional coefficient of 1.69 and a Stokes radium of 44.2 A. Amino acid analysis has revealed 34.0% acidic residues, 14.0% basic residues, and 4.0% tryptophan. The acidic nature of the molecule is further confirmed by its isoelectric point of 4.65. In the presence of 3 mM MgCl2 and 150 mM KCl, CAB-63 binds 3.0 mol of calcium/mol of protein with an apparent Kd = 0.1 microM. Immunoblotting and Ouchterlony double-diffusion procedures have identified CAB-63 in a variety of bovine tissues. Immunocytochemical staining of both fibroblasts and cryotome-sectioned bovine liver further indicates that CAB-63 immunoreactivity is restricted to an elaborate system of perinuclear membranous vacuoles and cisternae indistinguishable from immunocytochemical staining of the endoplasmic reticulum. It is concluded that CAB-63 represents a major calcium-binding protein whose subcellular organization suggests a possible role in the function of the endoplasmic reticulum.
Film condensation of downward flowing R-113 vapor on staggered bundles of horizontal finned tubes. (1991)

Film condensation of R-113 on staggered bundles of horizontal finned tubes with vertical vapor downflow was experimentally investigated. Six tubes with different fin geometry were tested. The behavior of condensate and the local heat transfer characteristics were compared with previous results for in-line bundles of the same test tubes and a staggered bundle of smooth tubes. The predictions of the previous theoretical model for a bundle of flat-sided fin tubes agreed fairly well with the measured data. The highest heat transfer performance was provided by the staggered bundle of flat-sided fin tubes with fin dimensions close to the theoretically determined optimum values.