gebhart/patrepeval huggingface dataset:
Design and characterization of a 20 Gbit/s clock recovery circuit (1995)

In this communication we report the design of a clock recovery circuit produced for the 20 Gbit/s demonstrator of the RACE 2011 project `TRAVEL' of the European Community. The clock recovery circuit is based on an open loop structure using a dielectric resonator narrow bandpass filter with a high quality factor. A detailed electrical characterization of the circuit and also its sensitivity to temperature and detuning variations are presented. The experimental results show that the circuit is a very attractive solution for the forthcoming STM-128 optical links.
Combination Treatment with Photodynamic Therapy and Laser Ablation in Breast Cancer: An Animal Model Study (2017)

The treatment method combining laser ablation and PDT showed superior results to single treatment techniques using just one of these approaches.
Obesity and Arterial Compliance Alterations (2010)

Obesity is associated with increased cardiovascular disease (CVD) risk, especially when excess body fat is distributed preferentially within the abdominal region. Obese subjects usually have increased arterial stiffness compared with non-obese subjects of similar age. The factors associated with increased arterial stiffness in obesity include endothelial dysfunction (decreased nitric oxide bioavailability), impaired smooth muscle cell function, insulin resistance, as well as elevated cholesterol and C-peptide levels. Furthermore, visceral fat, the adipose tissue-related renin-angiotensin-aldosterone system and hyperleptinaemia contribute to the obesity-associated impaired arterial compliance. Weight loss improves CVD risk factors and arterial compliance. Because increased arterial stiffness is a marker of CVD risk these findings support the concept that the presence of obesity has vascular implications.
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids (2020)

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, leads to respiratory symptoms that can be fatal. However, neurological symptoms have also been observed in some patients. The cause of these complications is currently unknown. Here, we use human-pluripotent-stem-cell-derived brain organoids to examine SARS-CoV-2 neurotropism. We find expression of viral receptor ACE2 in mature choroid plexus cells expressing abundant lipoproteins, but not in neurons or other cell types. We challenge organoids with SARS-CoV-2 spike pseudovirus and live virus to demonstrate viral tropism for choroid plexus epithelial cells but little to no infection of neurons or glia. We find that infected cells are apolipoprotein- and ACE2-expressing cells of the choroid plexus epithelial barrier. Finally, we show that infection with SARS-CoV-2 damages the choroid plexus epithelium, leading to leakage across this important barrier that normally prevents entry of pathogens, immune cells, and cytokines into cerebrospinal fluid and the brain.
EMMA The European mouse mutant archive (2007)

The European Mouse Mutant Archive (EMMA) offers the worldwide scientific community a free archiving service for its mutant mouse lines and access to a wide range of disease models and other research tools. EMMA is currently comprised of seven partners who operate as the primary mouse repository in Europe. EMMA' s primary objectives are to establish and manage a unified repository for maintaining mouse mutations and to make them available to the scientific community. In addition to these core services, the consortium can generate germ-free (axenic) mice for its customers and also hosts courses in cryopreservation. EMMA is a founder member of the Federation of International Mouse Resources (FIMRe). The EMMA network is funded by the participating institutes, national research programmes and the European Commission Research Infrastructures Programme.
Dietary Supplementation with Naringenin Attenuates Experimental Autoimmune Encephalomyelitis in Mice (2015)

The common therapies for autoimmune and inflammatory diseases have limited efficacy and often come with serious side effects. Dietary intervention may play a role in developing preventive and thera...
Identification of two genes,<i>cpsX</i>and<i>cpsY</i>, with putative regulatory function on capsule expression in group B streptococci (1998)

Two divergently transcribed open reading frames: cpsX and cpsY separated by a common regulatory region was identified upstream of the cpsA-D genes involved in polysaccharide capsule biosynthesis in group B streptococci (GBS). We suggest that these genes are involved in the regulation of capsule expression in GBS, since the CpsX protein shares sequence similarities with LytR of Bacillus subtilis, an attenuator of transcription while CpsY has similarity to a wide variety of members of the LysR family of transcriptional regulators. No deletions, insertions, DNA rearrangements, or apparent differences were discovered in the postulated regulatory genes when the gene region was compared in GBS with different capsule phenotypes. Thus, other yet unidentified gene loci may control capsule phase variation in GBS.
A New IC for Chroma Decoder Stage in TV Receiver (1980)

A new integrated chroma decoder has been designed in order to fill the need of a high performance compact SECAM decoder in TV receivers with essentially no trimming, and a low number of external components. The functions of this circuit are described on the following sections.
Ultra-high frequency acoustic impedance maps of MCF-7 cells (2014)

Acoustic impedance maps can be used to gain an insight into the microstructure and physiological state of cancer cells. In this we correlated acoustic impedance maps with cells structures detected by fluorescence microscopy. Fluorescence microscope was used to image MCF-7 cells marked with Celltracker Orange and Hoechst for staining the cytoplasm and nucleus, respectively. A single element 375MHz center frequency transducer (SASAM) was used to generate acoustic impedance maps of inverted MCF-7 cells on a plastic substrate. The acoustic impedance of 20 single-live, 10 clustered-live and 7 clustered-fixed MCF7 cells were measured and compared. Fluorescent images and acoustic impedance maps suggest that there is an acoustic impedance mismatch between the nucleus and the cytoplasm. The average acoustic impedance values for single-live, clustered-live and clustered-fixed cancer cells were measured to be 1.600±0.006 MRayl, 1.609±0.009 MRayl and 1.572±0.011 MRayl.
Poly[hexabromobis[μ<sub>3</sub>-1,3,5-tris(imidazol-1-ylmethyl)-2,4,6-trimethylbenzene]trimercury(II)] (2006)

In the title compound, [Hg 3 Br 6 (C 21 H 24 N 6 ) 2 ] n , the two Hg atoms (one of which lies on a twofold axis) are tetrahedrally coordinated by two Br atoms and two imidazole N atoms from two different 1,3,5-tris(imidazol-1-ylmethyl)-2,4,6-trimethylbenzene ligands. The complex has an infinite one-dimensional chain structure. The chains are further connected by C—H...Br interactions to form a three-dimensional framework.
Proximal abdominal graft for arterialization during hepatic transplantation. (1989)

A new method of arterial grafting during orthotopic hepatic transplantations is described herein. The advantages compared with other techniques include better exposure, less extensive dissection, reduced blood loss and, with correct anatomic orientation, a reduced risk of kinking the graft in a blind tunnel.
Dynamical Monte Carlo Modelling of Organic Solar Cells:  The Dependence of Internal Quantum Efficiency on Morphology (2005)

We present a dynamical Monte Carlo study of the dependence of the internal quantum efficiency (IQE) of an organic bulk heterojunction solar cell on the device morphology. The IQE is found to be strongly sensitive to the scale of phase separation in the morphology, with a peak at approximately 20 nm for the PFB/F8BT system studied. An ordered, checkered morphology exhibits a peak IQE 1.5 times higher than a disordered blend.
Pathogenesis of Respiratory Syncytial Virus Infection in the Murine Model (2005)

There is a wide spectrum of illness caused by respiratory syncytial virus (RSV) infection that is caused in large part by host-related factors, such as age of the patient and degree of host immunocompetency. Although the vast majority of persons infected with RSV experience symptoms of mild upper respiratory tract infection, in some people these infections cause significant morbidity and are sometimes fatal. Although a great deal of investigation in both humans and animals has explained the timing and tropism of RSV infection and the general principles by which the immune system responds to this infection, at present we only partially understand the disparity in illness severity that can occur. This article briefly reviews the clinical sequelae of RSV infection and then focuses on the mechanisms of viral pathogenesis.
Evolution of odd A transitional iridium nuclei at the strong deformation limit: levels of $\^{185}$Ir (1976)

A level scheme is proposed for neutron deficient /sup 185/Ir obtained by the decay of /sup 185/Pt produced with the ISOLDE on-line separator (CERN). This level scheme is compared to those of heavier mass iridium nuclei where the negative parity levels had been interpreted in the asymmetric-rotor-plus-particle model. In /sup 185/Ir similar systems of levels appear with a stronger prolate deformation of the nucleus. They seem correctly described by coupling an odd-particle (or a hole) to a symmetric rotor.
Herzinsuffizienz - eine wissenschaftliche und klinische Herausforderung (2011)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
CYP2D6 Mutations and Therapeutic Outcome in Schizophrenic Patients (1999)

Common CYP2D6 mutant alleles were not associated with schizophrenia or with disease symptoms, antipsychotic-related adverse effects, or attitudes toward treatment.
Optical nonlinear interactions in dielectric nano-suspensions (2009)

This work is divided into two main parts. In the first part (chapters 2-7) we consider the nonlinear response of nano-particle colloidal systems. Starting from the Nernst-Planck and Smoluchowski equations, we demonstrate that in these arrangements the underlying nonlinearities as well as the nonlinear Rayleigh losses depend exponentially on optical intensity. Two different nonlinear regimes are identified depending on the refractive index contrast of the nanoparticles involved and the interesting prospect of self-induced transparency is demonstrated. Soliton stability is systematically analyzed for both 1D and 2D configurations and their propagation dynamics in the presence of Rayleigh losses is examined. We also investigate the modulation instability of plane waves and the transverse instabilities of soliton stripe beams propagating in nonlinear nano-suspensions. We show that in these systems, the process of modulational instability depends on the boundary conditions. On the other hand, the transverse instability of soliton stripes can exhibit new features as a result of 1D collapse caused by the exponential nonlinearity. Many-body effects on the systems' nonlinear response are also examined. Mayer cluster expansions are used in order to investigate particle-particle interactions. We show that the optical nonlinearity of these nano-suspensions can range anywhere from exponential to polynomial depending on the initial concentration and the chemistry of the electrolyte solution. The consequence of these inter-particle interactions on the soliton dynamics and their stability properties are also studied. The second part deals with linear and nonlinear properties of optical nano-wires and the coupled mode formalism of parity-time (PT) symmetric waveguides. Dispersion properties of AlGaAs nano-wires are studied and it is shown that the group velocity dispersion in such waveguides can be negative, thus enabling temporal solitons. We have also studied power flow in nano-waveguides and we have shown that under certain conditions, optical pulses propagating in such structures will exhibit power circulations. Finally PT symmetric waveguides were investigated and a suitable coupled mode theory to describe these systems was developed.
Effect of vitamins A, C and E on normal and HPV-immortalized human oral epithelial cells in culture. (2000)

There is experimental and epidemiological evidence that antioxidant vitamins can inhibit carcinogenesis. Since immortalization by Human Papilloma Virus (HPV) is one possible early step towards carcinogenesis in oral epithelia, we studied the differential effect of vitamins A, C and E on HPV-immortalized oral epithelial cells (IHGK) as compared to the normal counterpart. The dose response was determined by morphology, cell cycle by flow cytometry, and growth curve by cell number. The optimum dose in terms of inhibitory effect vs. toxicity was determined for each vitamin by morphology. Optimum doses were: vitamin A--1.4 x 10(-5) M, vitamin C--10(-3) M, and vitamin E--10(-6) M for both HPV-immortalized and normal cells. Growth curve showed reduction of proliferation by all three vitamins, with vitamins A and E more effective than C for both cell types. Flow cytometry showed that vitamins A and E reduced the percentage of cells at G2 phase of cell cycle and indicated arrest in the S phase. This effect was greatest in the immortalized cells with a 50% and 35% decrease of G2 for vitamins A and E respectively, whereas the normal counterpart showed a 48% decrease for A and a 12% increase for E. By organotypic culture, the morphology was not markedly different between the vitamin-treated and the control cells, except for a slight increase in the keratinization of normal cells with vitamin A. Also noted was a reduction in number of cell layers from five layers or more for controls to only one or two for vitamin E. In conclusion, we have demonstrated that the antioxidant vitamins inhibit proliferation, and show a preferential effect on IHGK cells.
Grazing-incidence X-ray diffraction investigation of the coincidence site lattice of the Ge/Si(001) system (2020)

The Ge/Si(001) system has been analysed by grazing-incidence X-ray diffraction on a standard laboratory X-ray diffraction tool. A periodic array of interfacial edge dislocations forms a coincidence site lattice (CSL) which yields equidistantly spaced satellite peaks close to Bragg peaks of the Ge layer and Si substrate. The diffraction behaviour of the CSL was analysed using 2θ/φ scans along [100], [110] and [310] directions as well as azimuthal φ scans which revealed a 90° angular symmetry of the CSL. Additionally, different layer thicknesses, from 10 to 580 nm, were analysed, focusing on the dependence of layer thickness on the glancing angles of the satellite peaks. This method provides the ability to analyse whether or not epitaxially grown layers exhibit a periodic array of dislocations, and gain information about the orientation of the interfacial edge dislocations.
Is dual gate device structure better from thermal perspective? (2008)

Heating effects are investigated in dual-gate devices using an in-house thermal particle-based device simulator. Our simulation results demonstrate that the dual-gate device structure is advantageous even though there is slightly higher current degradation due to lattice heating compared to conventional single gate structures, since the magnitude of the on-current is 1.5-1.8 times larger in this structure. Thus, one can trade off a slight increase in current degradation due to lattice heating for more current drive.
Idiopathic Hypertrophic Spinal Pachymeningitis (2015)

A 63-year-old man revealed a four-month history of muscle weakness of the lower limbs, hypoesthesia of the L5 and S1 area and ischuria. On MRI, the spinal cord was compressed by an encircled mass, which showed hypointensity on T1- and T2-weighted images with gadolinium enhancement at the Th11 to Th12 vertebra. Because of the rapid progression of myelopathy, posterior decompression was performed and idiopathic hypertrophic spinal pachymeningitis (HSP) was finally diagnosed. The patient's neurological signs markedly improved with postoperative corticosteroid treatment. Idiopathic HSP is a clinical emergency and early surgical intervention is essential to prevent irreversible damage to the nervous system.
Regioselective cross-linking of silica aerogels with magnesium silicate ceramics (2013)

Nanoporous monoliths with a typical aerogel core and a mechanically robust exterior ceramic layer were synthesized from silica aerogels cross-linked with polyacrylonitrile (X-PAN aerogels). Following supercritical drying, X-PAN aerogels were wrapped in Mg and heated to 850 °C in inert atmosphere to generate Mg-PAN monoliths. Mg penetrated 2–3 mm inside the monolith, reacted with the silica framework and formed a mechanically strong crust with a hardness of 28 MPa, a reduced Young modulus of 374 MPa and a surface area of 170 m2 g−1. The core of the monoliths maintained chemical and physical characteristics close to those of native silica aerogels with a hardness of 0.81 MPa, a modulus of 7.42 MPa and a surface area of 370 m2 g−1. The cross-linking crust was composed of forsterite (Mg2SiO4), enstatite (MgSiO3), cristobalite and magnesium oxide (MgO). SEM and TEM showed that the Mg silicates bridged between silica aggregates, thus realizing the first known example of ceramic cross-linking of aerogels. Control experiments showed that carbon from PAN was responsible for the crust formation. A thin, mechanically weak crust formed in all other samples and was composed of MgO and Mg2SiO4. EELS showed the presence of disordered, graphite-type carbon in Mg-PAN aerogels and traces of amorphous carbon in all other control samples. The role of PAN was confirmed by using masking techniques, whereas acrylonitrile was photopolymerized in selected regions of aerogel monoliths. The crust formed only in these exposed regions. The role of carbon in crust formation is discussed, as well as potential applications of our technique for the fabrication of anisotropic ceramics.
Reactions of the Benzil-Triethyl Phosphite Adduct (1966)

Abstract The decomposition of benzil-triethyl phosphite adduct in the presence of copper powder or cupric sulfate has been studied. When benzil, triethyl phosphite and cupric sulfate were treated in boiling toluene. cis-dibenzoylstilbene and triethyl phosphate were obtained. When the reaction was carried out in the presence of active hydrogen compounds, such as alcohol, carboxylic acid and amine, the corresponding benzoin derivatives were obtained. Further, when the adduct was decomposed in the presence of phenyl isocyanate or dicyclohexylcarbodiimide, 3, 4, 5-triphenyl-4-oxazoline-2-one or 2-cyclohexylimino-3-cyclohexyl-4, 5-diphenyl-4-oxazoline was obtained, along with triethyl phosphate.
Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (2017)

Thiomarinol and mupirocin are assembled on similar polyketide/fatty acid backbones and exhibit potent antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA). They both contain a tetrasubstituted tetrahydropyran (THP) ring that is essential for biological activity. Mupirocin is a mixture of pseudomonic acids (PAs). Isolation of the novel compound mupirocin P, which contains a 7-hydroxy-6-keto-substituted THP, from a ΔmupP strain and chemical complementation experiments confirm that the first step in the conversion of PA-B into the major product PA-A is oxidation at the C6 position. In addition, nine novel thiomarinol (TM) derivatives with different oxidation patterns decorating the central THP core were isolated after gene deletion (tmlF). These metabolites are in accord with the THP ring formation and elaboration in thiomarinol following a similar order to that found in mupirocin biosynthesis, despite the lack of some of the equivalent genes. Novel mupirocin-thiomarinol hybrids were also synthesized by mutasynthesis.
2A1-A09 Whole-body Tactile Sensing by a Force Sensor Using Soft Material at Contact Areas : Haptic Armor Using Soft Material(Tactile and Force Sensing (1)) (2013)

This paper proposes whole-body tactile sensing by a force sensor using soft material at contact areas. The previous method proposed by authors has used rigid materials at contact areas. In term of safe assurance, the material should have character to absorb a shock. Hence we use urethane sponge at contact areas and in the case of whole-body tactile sensing using the soft material, calculate the contact point. First, the relationship between external force and displacement of the urethane sponge is measured. Second, whole-body tactile sensing using soft material at contact areas is verified. Finally, this paper presents compensation for transformation of the soft material and verified its validity.
Improved visualization in virtual colonoscopy using image-based rendering (2001)

Virtual colonoscopy (VC) is a patient-friendly alternative for colorectal endoscopic examination. We explore visualization aspects of VC such as surface in view, navigation and communication of a diagnosis. A series of unfolded cubes presents an animated full 360-degree omnidirectional field-of-view to the physician, to facilitate thorough and rapid inspection. For communication between physicians a tool has been designed that uses image-based rendering. Clinical evaluation has shown a reduction in inspection time from 19 minutes to 7 minutes without loss of sensitivity. With current virtual colonoscopy using a 2-sided view only 94% of the surface is available for exploration. In our approach the surface in view is increased to potentially 100%. Thus, the entire colon can be explored with better confidence that no regions are missed.
Age-dependent differences in diabetes and acute hyperglycemia between men and women with ST-elevation myocardial infarction: a cohort study (2013)

The differences between men and women in hyperglycemia and diabetes in patients with STEMI are age dependent and can only be observed in older patients. This may have implications for medical treatment and should be investigated further.
The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product (2002)

Neurofibromatosis type 2 is an autosomal dominant disorder characterized by central nervous system tumors. The cause of the disease has been traced to mutations in the gene coding for a protein that is alternately called merlin or schwannomin and is a member of the ERM family (ezrin, radixin and moesin). The ERM proteins link the cytoskeleton to the cell membrane either directly through integral membrane proteins or indirectly through membrane-associated proteins. In this paper, the expression, purification, crystallization and crystal structure of the N-terminal domain of merlin are described. The crystals exhibit the symmetry of space group P2(1)2(1)2(1), with two molecules in the asymmetric unit. The recorded diffraction pattern extends to 1.8A resolution. The structure was solved by the molecular-replacement method and the model was refined to a conventional R value of 19.3% (R(free) = 22.7%). The N-terminal domain of merlin closely resembles those described for the corresponding domains in moesin and radixin and exhibits a cloverleaf architecture with three distinct subdomains. The structure allows a better rationalization of the impact of selected disease-causing mutations on the integrity of the protein.