gebhart/patrepeval huggingface dataset:
Laboratory Studies Associated with Field Trials of Monovalent Oral Poliovirus Vaccines (1960)

Journal Article Laboratory Studies Associated with Field Trials of Monovalent Oral Poliovirus Vaccines Get access Manuel Roca-Garcia, Manuel Roca-Garcia From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ernest V. Orsi, Ernest V. Orsi From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar George A. Jervis, George A. Jervis From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Floyd S. Markham, Floyd S. Markham From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Juan C. Bacigalupi, Juan C. Bacigalupi From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hanna Doany, Hanna Doany From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hector Tosi, Hector Tosi From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Victor J. Cabasso, Victor J. Cabasso From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Arden W. Moyer, Arden W. Moyer From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Herald R. Cox Herald R. Cox From the Viral and Rickettsial Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 107, Issue 3, November 1960, Pages 300–317, https://doi.org/10.1093/infdis/107.3.300 Published: 01 November 1960 Article history Received: 16 February 1960 Published: 01 November 1960
MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption (2009)

Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. Potential sources of exposure still have to be determined, as, to date, only a few batches of products for human consumption were searched for these compounds. To assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using MALDI-TOF MS, with minimal sample preparation. Development of the technique is discussed. Its application to leaves of herbal tea, pulp and bottled nectar of Annona muricata is presented.
Detection of Mixed Infections with “<i>Candidatus</i> Mycoplasma Haemominutum” and <i>Mycoplasma Haemofelis</i> Using Real-Time TaqMan Polymerase Chain Reaction (2007)

The objective of this study was to evaluate the use of real-time TaqMan PCR assays for detection of coinfections with "Candidatus Mycoplasma haemominutum" (Mhm), and Mycoplasma haemofelis (Mhf), in vitro and over time in experimentally infected cats. First, the ability of each real-time PCR assay to detect and quantify mixed infections was determined in vitro by testing mixtures of plasmids containing Mhm and Mhf 16S rDNA with each assay. Subsequently, 4 specific pathogen-free (SPF) cats, 2 of which were splenectomized, were inoculated with blood from a cat infected with both Mhm and Mhf. Sixteen blood samples were then collected from each cat over a 55-day period. Each of the 64 postinoculation samples was tested using both conventional polymerase chain reaction (cPCR) and real-time PCR for the 16S rRNA gene of each organism. When applied to mixtures of plasmid DNA from each species, the results of quantitation with each of the real-time PCR assays approximately reflected the number of plasmid copies present. Forty-nine of 64 post-inoculation samples (77%) were positive using both cPCR and real-time PCR, 4 (6%) were positive using cPCR only, and 3 (5%) were positive using real-time PCR only. Both organisms were detected in 23 samples using real-time PCR. Mixed infections were not detected using cPCR. The size of the corresponding cPCR products suggested infection with Mhm in 4 and Mhf in 18 of these samples. The use of multiple separate real-time PCR assays rather than cPCR alone should thus be considered for epidemiologic studies of hemoplasmosis in cats.
Synthetic Functionalities for Ion and Electron Conductive Polymers : Applications in Organic Electronics and Biological Interfaces (2021)

In the search for understanding and communicating with all biological systems, in humans, animals, plants, and even microorganisms, we find a common language of all communicating via electrons, ions and molecules. Since the discovery of organic electronics, the ability to bridge the gap and communicate between modern technology and biology has emerged. Organic chemistry provides us with tools for understanding and a material platform of polymer electronics for communication. Such insights give us not only the ability to observe fundamental phenomenon but to actively design and construct materials with chemical functionalities towards better interfaces and applications. Organic electronic materials and devices have found their way to be implemented in the field of medicine for diagnostic and therapeutic purposes, but also in water purification and to help tackle the monumental task in creating the next generation of sustainable energy production and storage. Ultimately it's safe to say that organic electronics are not going to replace our traditional technology based on inorganic materials but rather the two fields can find a way to complement each other for various purposes and applications. Compared to conventional silicon based technology, production of carbon-based organic electronic polymer materials are extremely cheap and devices can even be made flexible and soft with great compatibility towards biology.
Design and Development of Recombinant Vaccines with Viral Properties (2011)

This chapter contains sections titled: Introduction Viral Properties and Immune Responses Translating Immunogenic Viral Properties into Rationally Designed Vaccines Conclusion References
Evacuated FM08 Fuses Carry a Sustained Arc in a Bus over 75 VDC (1999)

Abstract The FM08 style fuse is specified to interrupt an overcurrent of up to 300 A in a bus of up to 125 VDC, but this applies only when its barrel is filled with air. When placed into a space-grade vacuum, the FM08 style fuse exhausts its air within a year. Then, the probability of an enduring arc is high for all ratings when the bus is above 75 VDC, and the overcurrent is large. The arc endures until something else interrupts the current. The fuse can violently eject metal vapor or other material during the sustained arcing. The evacuated FM08 does not develop a sustained arc when interrupted in a bus of 38 VDC or less, at least when there is little inductance in the circuit. This is consistent with its successful use in many spacecraft having buses in the range 24 to 36 volts.
A fragmentation study of dihydroquercetin using triple quadrupole mass spectrometry and its application for identification of dihydroflavonols in <i>Citrus</i> juices (2009)

A mass spectrometric method using electrospray ionization with triple quadrupole and quadrupole time-of-flight hybrid (Q-Tof) mass spectrometry has been applied to the structural characterization of dihydroflavonols. This family of compounds has been studied by liquid chromatography/tandem mass spectrometry (LC/MS/MS) for the first time in this work. A comprehensive study of the product ion MS spectra of the [M+H](+) ion of a commercially available standard has been performed. The most useful fragmentations in terms of structural identification are those that involve cleavage of the C-ring, resulting in diagnostic ions of dihydroflavonol family: (1,3)A(0) (+), (1,2)B(0) (+), (1,2)B(0) (+)-CO, (0,2)A(0) (+), (0,2)A(0) (+)-H(2)O, (0,2)A(0) (+)-CO, and (0,2)A(0) (+)-H(2)O-CO, that allow the characterization of the substituents in the A- and B-rings. In addition to those ions, other product ions due to losses of H(2)O and CO molecules from the Y(0) (+) ion were observed. Their fragmentation mechanisms and ion structures have been proposed. The established fragmentation patterns have been used to successfully identity three dihydroflavonols found in tangerine juices for the first time.
Chromosomal Location and Properties of Radiation Sensitivity Mutations in <i>Bacillus subtilis</i> (1970)

Transformation and transduction crosses involving recA1, recB2, and urv-1 mutations have shown that these mutations belong to three distinct unlinked genetic loci. The precise position of these loci on the Bacillus subtilis chromosome map has been determined. The behavior of recB2 strains in transformation studies suggested a dominance of recB2(+) function over recB2 and an early expression of this phenotype during transformation. Strains bearing two ultraviolet sensitivity markers possess a phenotype characteristic of the marker with the most adverse effect on recombination. The possibility that the effects of the two mutations are additive was also considered. Results are also presented which show that a phage-induced enzyme is not responsible for the high transducibility of recA1 strains.
Deterministic control of mean alignment and elongation of neuron-like cells by grating geometry: a computational approach (2015)

Neuron-like cells are driven by their surrounding environment through local topography. A causal mechanotransductive web of topography-force relationships influences and controls complex cellular phenomena such as growth and alignment. This work aimed to provide a computational framework able to model the behaviour of neuron-like (PC12) cells on gratings, accounting for the twofold ability of topographical cues to simultaneously align and enhance the growth of cells. In particular, starting from the mechanical behaviour of the growth cone and filopodia, the effect of grating geometry (e.g., the periodicity and the size of grooves and ridges) on the neuritic mean alignment angle and on the outgrowth rate of cells was explored through theoretical tools and combinatorial simulations, which were able to predict (R(2) > 0.9) experimental data in a time range of 72-120 hours.
ULTIMATE STRENGTH OF LEG OF JACK-UP RIG, 2ND REPORT: LOCAL RIGIDITY AND ULTIMATE STRENGTH OF T-JOINT UNDER NORMAL LOAD AND BENDING MOMENT (1985)

The metabolic clearance rate (MCR) of norethindrone acetate (NETA) and norethindrone (NET) levels in plasma were studied after an iv injection of [3H]NETA in three women before and at 1 week, 1, 2 and 6 months following the insertion of a single silastic subdermal implant releasing microquantities of NETA. No significant change in the MCR of NETA was observed at 1 week (459 +/- 72 1/day), 1 month (489 +/- 113 1/day) and 2 months (522 +/- 144 1/day) compared with that of control (525 +/- 108 1/day). However, MCR of NETA showed significant increase in women exposed to continuous presence of NETA for a period of 6 months (608 +/- 121 1/day; P less than 0.025). NETA was rapidly and extensively metabolized into NET. At 1 week, 1, 2 and 6 months of study, NET was observed to be present in higher amounts compared with NETA. The production rate (PR) of progesterone decreased significantly at 2 and 6 months of NETA implant insertion compared with the PR before the insertion of implant.
RITPBC: B-cell depleting therapy (rituximab) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial (2015)

ISRCTN03978701.
Phase formation, microstructure, and hard magnetic properties of electrodeposited FePt films (2004)

FePt films of different compositions have been electrodeposited on Cu coated Si substrates. After deposition films were annealed at temperatures up to 900 °C for 10 min. Phase formation, microstructure, and magnetic properties are analyzed. From these measurements, necessary conditions to obtain good hard magnetic properties are concluded. Remanence reaches a maximum value at 800 °C annealing temperature, while coercivity continuously increases for annealing temperatures up to 900 °C. A coercivity of 0.42 T has been achieved in this case.
CHANGES IN THE PROPERTIES OF ION-EXCHANGE RESINS PRODUCED BY IRRADIATION WITH IONIZING RADIATION (1958)

Changes in the exchange capacity, activity index, swelling in water, and in the solubllity of ion exchange resins (IER) produced by exposure to x rays were investigated. The changes produced when dry and waterswollen IER are irradiated with x rays are quite different. Direct irradiation effects were established as well as an indirect hydroxylation effect which is proportional to the degree of swelling of the IER.
Propagation-decay characteristics of locally ionized microplasma packets in arrays of microchannels (2013)

Summary form only given. Plasma propagation and its decay properties in an array of microscale channels has been investigated at atmospheric pressure in He and Ar. Microplasmas in channels having a width of 200-300 μm, a length to width aspect ratio of up to ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> : 1, and a volume of 1-50 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> have been generated by micromachining and wet chemical processes, these channels are situated in a dielectric barrier structure fabricated in 125-250 μm thick Al foil. Spatiotemporally-resolved optical emission profiles, recorded with a gated CCD camera and a telescope, reveal a plasma optical interaction with neighboring channels and propagation speed (and direction of excited emission along the microchannel) which varies with gas mixture. In Ar 760 Torr, propelled by the accumulation of charge on the microchannel wall, packets of low temperature, nonequilibrium plasma propagate at a uniform velocity of ~20 km-s <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . The dominant mechanism for volumetric electron loss to be dissociative recombination.
From OBOC combinatorial chemistry to glioblastoma targeting (2007)

C121 There is a need to develop cell surface targeting ligands for glioblastoma. The one-bead one-compound (OBOC) combinatorial library method is an enabling technology that allows one to probe tens of thousands to millions of different synthetic compounds against various molecular targets, which include soluble proteins or intact cells. The OBOC chemical library consists of large number of 90 micron polystyrene beads, each displaying a unique peptide, peptidomimetic or small molecule. When the compound-bead library is mixed with intact cancer cells, beads that coated with cancer cells can be physically isolated and chemically decoded (1). Using these methods, we have identified high-affinity peptidic and peptidomimetic ligands against lymphoid cancer (2) and ovarian cancer (3). We have further demonstrated their excellent in vivo targeting potential in xenograft model and canine model. Recently, we applied the same approach to screen OBOC combinatorial cyclic peptide libraries, and through several cycles of discovery and optimization, we succeeded in identifying cyclic peptides (LXY1 and LXY3) that target U-87 human glioblastoma cell line with high affinity and specificity. In vivo optical imaging studies demonstrated that these ligands were able to target both orthotopic and subcutaneous U-87 implant with high specificity. Work is currently underway in our laboratory to develop LXY1 and LXY3 into therapeutic targeting agents, using these cyclic peptides as vehicles to deliver radionuclides and cytotoxic agents to orthotopic and subcutaneous glioblastoma implants. In conclusion, OBOC combinatorial chemistry is a powerful and proven method for the development of cancer targeting agents.  References  1. Aina OH, Liu R, Sutcliffe-Goulden JL, Marik J, Pan C, and Lam KS. From Combinatorial Chemistry to Cancer Targeting Peptides. Molecular Pharmaceutics, in press, 2007.  2. Peng L, Liu R, Marik J, Wang X, Takada Y, Lam KS. Combinatorial Chemistry Identifies High-Affinity Peptidomimetics against α4β1 Integrin. Nature Chemical Biology, 2(7). 381-389, 2006.  3. Aina OH, Marik J, Liu R, Lau DH, and Lam KS: Identification of novel targeting peptides for human ovarian cancer cells using OBOC combinatorial libraries. Molecular Cancer Therapeutics, 4:806-813, 2005.
The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells. (2003)

These studies indicate that gamma-irradiation followed by flavopiridol enhances apoptosis and yields significantly increased tumor regressions and cures that are not achievable with radiation alone. These results indicate that flavopiridol can potently enhance the effect of gamma-radiation both in vitro and in vivo and may provide a new means to treat patients with locally advanced gastrointestinal cancers.
Low-temperature measurements of the specific heat capacity of a thick ferroelectric copolymer film of vinylidene fluoride and trifluoroethylene (2008)

The specific heat capacity ${c}_{p}$ of a $110\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{m}$ thick and partially crystallized $(\ensuremath{\sim}77%)$ ferroelectric copolymer film of vinylidene fluoride (PVDF) $(\ensuremath{\sim}75\phantom{\rule{0.3em}{0ex}}\mathrm{mol}\phantom{\rule{0.2em}{0ex}}%)$ and trifluoroethylene $(\ensuremath{\sim}25\phantom{\rule{0.3em}{0ex}}\mathrm{mol}\phantom{\rule{0.2em}{0ex}}%)$ was measured from $2\phantom{\rule{0.3em}{0ex}}\text{to}\phantom{\rule{0.3em}{0ex}}20\phantom{\rule{0.3em}{0ex}}\mathrm{K}$. The temperature dependence of ${c}_{p}∕{T}^{3}$ reveals a shallow hump, centered at $\ensuremath{\sim}5\phantom{\rule{0.3em}{0ex}}\mathrm{K}$, consistent with non-Debye behavior of semicrystalline materials. These ${c}_{p}$ data were used, in conjunction with previous measurements of the pyroelectric coefficient $\ensuremath{\mid}{p}^{\ensuremath{'}}\ensuremath{\mid}$, to infer the temperature profile of the macroscopic Gr\"uneisen parameter based on ratios of $\ensuremath{\mid}{p}^{\ensuremath{'}}\ensuremath{\mid}∕{c}_{p}$. Comparisons with similar data for PVDF are consistent with a correlation between anharmonicity of the interaction potential and excess specific heat capacity.
Phenylmercuric hydroxide. A highly selective reagent for the hydration of nonconjugated terminal alkynes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhenylmercuric hydroxide. A highly selective reagent for the hydration of nonconjugated terminal alkynesVaclav Janout and Steven L. RegenCite this: J. Org. Chem. 1982, 47, 17, 3331–3333Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/jo00138a029https://doi.org/10.1021/jo00138a029research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Model for the formation of nonequilibrium clusters (1986)

We propose a new and simple model for the formation of kinetic clusters. The model appears to have two critical points. The first one corresponds to a site percolation threshold, at which point a fractal structure appears for the first time, and below which the clusters stop growing after a finite time. The second critical point appears to be exactly the same as the site percolation threshold of the lattice in the directed percolation process, and at which point a qualitative change in the structure of the cluster appears. Various critical properties of the model are computed in two dimensions and they appear to be slightly but consistently different from those of random percolation. The clusters reduce to the Eden model in a special limit, and they appear also to have close connection with ballistic aggregation and cellular automata.
Design and operation of a pilot‐plant fermentor for the continuous propagation of filamentous microorganisms (1962)

Abstract A multi‐stage pilot fermentor was designed which consists of nine stainless steel cylindrical compartments 2 ft. in length and 8 in. in diameter, joined end to end, giving a tube with a total length of 18 ft. The whole apparatus was mounted with its axis in a horizontal plane. Each compartment was sealed off from its neighboring compartment by a separatory plate having a 1‐in. overflow hole in the upper half. Shafts 9½ feet long extended from each end of the fermentor through the compartments to the center. Agitation was provided by a multitude of stainless steel blades mounted at right angles to the shafts and spaced at regular intervals along the shafts. Stationary, stainless steel comb‐shaped baffle plates were installed vertically at the bottom of each compartment to increase mixing efficiency. Constant leaving and re‐entering of the fermentation liquor by the blades upon rotation imparts a shattering of the liquid surface thus preventing the accumulation of mycelial aggregates on the walls above the fermentation liquor. The mechanical performance of the described fermentor has proved excellent and several trial fermentations (antibiotic formation and steroid bioconversion) are described.