gebhart/patrepeval huggingface dataset:
A measurement of rotation loss characteristics of high-Tc superconducting magnetic bearings and active magnetic bearings (1999)

As the demand for electric power has been increasing steadily, the introduction of a flywheel energy storage system (FESS) using a superconducting magnetic bearing (SMB) is needed to level daily load as much as possible (daily load-leveling). We have studied rotation loss characteristics of SMBs with high Tc superconductors (YBCO) and permanent magnets (PM) for supporting a flywheel in FESS. We have designed and manufactured a testing machine for measuring rotation loss characteristics of SMBs. The rotor is suspended by two sets of radial active magnetic bearings (RaAMBs), a set of axial active magnetic bearings (AxAMB) and a set of SMB. Then, we obtained rotation loss characteristics of the rotor levitated by RaAMBs, AxAMB and SMB on this testing machine.
Use of Perchloric Acid Filtrate and Stabilized Anthrone for Determination of Serum Glucose (1953)

Journal Article Use of Perchloric Acid Filtrate and Stabilized Anthrone for Determination of Serum Glucose. Get access VIvian Kapuscinski, VIvian Kapuscinski Departments of Pathology, Wayne University and Detroit Receiving Hospital, Detroit, Michigan Search for other works by this author on: Oxford Academic Google Scholar Bennie Zak, PH.D. Bennie Zak, PH.D. Departments of Pathology, Wayne University and Detroit Receiving Hospital, Detroit, Michigan Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 23, Issue 8, 1 August 1953, Pages 784–788, https://doi.org/10.1093/ajcp/23.8.784 Published: 01 August 1953 Article history Received: 20 January 1953 Published: 01 August 1953
The Influence of Tire Wear on Steering Properties and the Corresponding Stresses at the Tread-Road Interference (1974)

The paper presents data showing the effects of the state of wear, structure, load, and inflation pressure on the cornering stiffness and aligning torque stiffness of typical passenger tires. A method is introduced and applied for assessing contributions of local elements of the tread interface to the cornering force, the cornering stiffness, the aligning torque, and the aligning stiffness. There is also a further identification of the contributions to the aligning torque from fore and aft interfacial stress distributions and from lateral stress distributions. Pneumatic trail is redefined in the light of the interfacial measurements, and values are established for various operating conditions, states of wear, and tire types.
On-line adaptive learning of the correlated continuous density hidden Markov models for speech recognition (1998)

We extend our previously proposed quasi-Bayes adaptive learning framework to cope with the correlated continuous density hidden Markov models (HMMs) with Gaussian mixture state observation densities in which all mean vectors are assumed to be correlated and have a joint prior distribution. A successive approximation algorithm is proposed to implement the correlated mean vectors' updating. As an example, by applying the method to an on-line speaker adaptation application, the algorithm is experimentally shown to be asymptotically convergent as well as being able to enhance the efficiency and the effectiveness of the Bayes learning by taking into account the correlation information between different model parameters. The technique can be used to cope with the time-varying nature of some acoustic and environmental variabilities, including mismatches caused by changing speakers, channels, transducers, environments, and so on.
Transactivation properties of c‐Myb are critically dependent on two SUMO‐1 acceptor sites that are conjugated in a PIASy enhanced manner (2003)

The transcription factor v-Myb is a potent inducer of myeloid leukemias, and its cellular homologue c-Myb plays a crucial role in the regulation of hematopoiesis. Recently, Bies and coworkers (Bies, J., Markus, J. & Wolff, L. (2002) J. Biol. Chem, 277, 8999-9009) presented evidence that murine c-Myb can be sumoylated under overexpression conditions in COS7 cells when cotransfected with FLAG-tagged SUMO-1. Here we provide independent evidence that human c-Myb is also subject to SUMO-1 conjugation under more physiological conditions as revealed by coimmunoprecipitation analysis of Jurkat cells and transfected CV-1 cells. Analysis in an in vitro conjugation system showed that modification of the two sites K503 and K527 is interdependent. A two-hybrid screening revealed that the SUMO-1 conjugase Ubc9 is one of a few major Myb-interacting proteins. The moderate basal level of sumoylation was greatly enhanced by cotransfection of PIASy, an E3 ligase for SUMO-1. The functional consequence of abolishing sumoylation was enhanced activation both of a transiently transfected reporter gene and of a resident Myb-target gene. When single and double mutants were compared, we found a clear correlation between reduction in sumoylation and increase in transcriptional activation. Enhancing sumoylation by contransfection of PIASy had a negative effect on both Myb-induced and basal level reporter activation. Furthermore, PIASy caused a shift in nuclear distribution of c-Myb towards the insoluble matrix fraction. We propose that the negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on the sumoylation sites located here.
A conservative algorithm for computing the flow of permissions in Java programs (2002)

Open distributed systems are becoming increasingly popular. Such systems include components that may be obtained from a number of different sources. For example, Java allows run-time loading of software components residing on remote machines. One unfortunate side-effect of this openness is the possibility that "hostile" software components may compromise the security of both the program and the system on which it runs. Java offers a built-in security mechanism, using which programmers can give permissions to distributed components and check these permissions at run-time. This security model is flexible, but using it is not straightforward, which may lead to insufficiently tight permission checking and therefore breaches of security.In this paper, we propose a data flow algorithm for automated analysis of the flow of permissions in Java programs. Our algorithm produces, for a given instruction in the program, a set of permissions that are checked on all possible executions up to this instruction. This information can be used in program understanding tools or directly for checking properties that assert what permissions must always be checked before access to certain functionality is allowed. The worst-case complexity of our algorithm is low-order polynomial in the number of program statements and permission types, while comparable previous approaches have exponential costs.
The New Beta-Lactamase-Stable Cephalosporins (1982)

The proliferation of new beta-lactam compounds is due to the increased resistance of gram-negative bacteria to existing compounds, an increased awareness of the toxic potential of other antimicrobial agents such as the aminoglycosides, and advances in chemistry that allow production of new cephalosporins or oxacephem compounds with extraordinary in-vitro action. The antibacterial spectrum of the new cephalosporins, combined with their excellent pharmacokinetic properties and retention of the safety of the older agents of this class, suggest that these drugs can be used in many clinical situations. But the manner in which the new cephalosporins should replace the older agents is not known. The new cephalosporins should not be used to treat infections that can be effectively cured with inexpensive older penicillins or cephalosporins.
Air injection into concentrated maple sap during processing: impact on syrup composition and flavour (2009)

Abstract BACKGROUND: Air injection (AI) is a relatively new process used during maple sap thermal processing to increase the profitability of maple syrup production by increasing the production of more economically valuable light‐coloured syrup. The effects of applying this technology in conjunction with existing practices employed to increase the efficiency of maple production, such as reverse osmosis (RO), are unknown. The main objective of this work was to investigate the effects of AI on syrup chemical composition and flavour when applied to maple sap concentrated by RO. RESULTS: The chemical composition and flavour of syrup produced simultaneously with and without AI from a common source of maple sap concentrated by RO were compared. The chemical composition of maple syrup produced with AI was within ranges previously published for maple syrup. Syrup produced with AI was significantly lighter in colour than syrup produced without AI from the same sap concentrate ( P < 0.001). Although syrup produced with AI contained fewer volatile flavour compounds and had a flavour distinguishable from that of syrup produced without AI from the same concentrated sap, the flavour properties of AI syrup were consistent with those of light‐coloured maple syrup. CONCLUSION: The results indicate that AI can be used in conjunction with RO to effectively increase the economic efficiency of maple syrup production without detrimental impacts on maple syrup properties. Copyright © 2009 Society of Chemical Industry
Antimicrobial central venous catheters in oncology: efficacy of a rifampicin-miconazole-releasing catheter. (2010)

Immunocompromized patients suffering from cancer, transplantation, and dialysis patients with a long-term vascular access may mostly benefit from rifampicin-miconazole-releasing catheters.
Vulnerabilidad de la flora y vegetación españolas ante el cambio climático (2012)

Griffith, D.M., Coronado, I., Asa, C., Polisar, J., Carmona, I. (2012). Vulnerability of the Spanish flora, vegetation to climate change. Ecosistemas 21(3):1-6. Doi.: 10.7818/ECOS.2012.21-3.01 Vulnerability of the Spanish flora, vegetation to climate change. In this paper we present the results of a research project aiming to evaluate the vulnerability of the Spanish flora, vegetation to climate change. Species distribution models were generated for the current climatic conditions,, projected into modeled future conditions. The estimated evolution of 75 forest taxa, 145 threatened species showed that 23% of the former, 43% of the latter face a high or very high vulnerability risk.
Abstract 1023: Cytoplasmic domain of interferon-gamma receptor beta chain (IFNγR2) has an antiapoptotic activity as a Bax inhibitor (2010)

Abstract Bax is a pro-apoptotic protein mediating intrinsic cell death signal. New Bax inhibitor was searched by using yeast-based functional screening, and Interferon Gamma Receptor Beta chain (IFNγR2) was cloned as a Bax suppressor. IFNγR2 is a receptor protein, which is a part of the IFNγ receptor complex with IFNγR1, involved in the Jak/STAT signaling pathway. Upon IFNγ binding a conformational change in the receptor complex occurs, followed by activation of Jak kinases, and STAT1. We found that the C-terminus region of IFNγR2 amino acids 296-337 (IFNγR2296-337) contains the novel Bax inhibiting domain. This portion does not contain the Jak2 binding domain, therefore IFNγR2 anti-apoptotic function is independent of the well characterized JAK/STAT signaling. IFNγR2296-337 rescued human cells from apoptosis induced by overexpression of Bax, but not Bak. Overexpression of IFNγR2 (wild type and IFNγR2296-337) rescued cells from apoptosis induced by Etoposide and Staurosporine that are known to activate Bax-mediated cell death. Interestingly, IFNγR2 inhibited apoptosis induced by the BH3 only protein Bim-EL, suggesting that IFNγR2 inhibits Bax activation by BH3 protein. The binding of Bax and the C-terminus of IFNγR2 was confirmed by co-immunoprecipitation using cell lysate and binding experiments using purified recombinant proteins. Interestingly, recombinant Bcl-2 protein competed with IFNγR2 to bind Bax in cell lysates, suggesting that IFNγR2 and Bcl-2 share a similar mechanism to bind Bax. We found that the C-terminal fragment (cytoplasmic domain) of IFNγR2 is expressed in the cytosol of transformed, and in some human prostate cancer cell lines (PC3, and DAMI cells). Our preliminary study suggests that the cytoplasmic IFNγR2 C-terminal fragment is produced by proteolytic cleavage of IFNγR2 at the plasma membrane. The cytoplasmic IFNγR2 fragment may have a certain role to confer cancer cells resistant to apoptotic stress. The discovery of anti-Bax activity of the cytoplasmic domain of INFγR2 may shed new light on the mechanism of how cell survival is controlled by IFNγ and Bax. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1023.
Polarization feedback stabilization of an injection-seeded Nd:YAG laser for spectroscopic applications (1987)

We have achieved reliable operation of a tunable, single-mode injection-seeded Nd:YAG laser that incorporates a novel feedback scheme to maintain the required match between the master- and slave-resonator cavity lengths. The reliability of the system is illustrated by both fluorescence excitation and sub-Doppler polarization spectra of I2 taken with the second-harmonic output of the slave laser while temperature tuning the injected frequency from the master oscillator. These spectra should prove extremely useful for long-term stabilization of the system to an absolute frequency reference.
Multiple Myeloma and Chronic Lymphocytic Leukemia: Commonalities and Differences in Biology and Therapy (1991)

Multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) are monoclonal tumors of differentiated B-cells arising late in life with a protracted clinical course that frequently terminates with signs of dedifferentiation. The major clinical differences (extramedullary spread in CLL, bone marrow confinement in MM) may relate to distinctive tumor cell phenotypes and cytokine networks, explaining the frequent bone involvement and uncommon thrombocytopenia in advanced MM. Cytogenetically, CLL is characterized by relatively uniform chromosomal abnormalities with a predominance of trisomy 12 without further changes with disease progression, whereas complex and seemingly random numeric and structural chromosomal aberrations predominate in MM. Multilineage expression and the association with acute myelogenous leukemia suggest that MM may result from transformation of a pluripotent progenitor cell, whereas CLL is thought to develop from a transformed committed B-cell precursor compartment. Survival of patients with MM and CLL is shorter in the presence of higher tumor burden, reflected in increasing anemia in both diseases and in high levels of serum beta-2-microglobulin in MM. Both tumors respond to alkylating agents providing disease palliation but no cures. Glucocorticoids are highly effective in MM and control autoimmune disease associated more frequently with CLL. The marked efficacy of fludarabine in CLL and its lack of activity in MM may provide additional clues about the different biology of CLL and MM.
Potential of active and passive immunizations for the prevention and therapy of transmissible spongiform encephalopathies (2007)

Transmissible spongiform encephalopathies are fatal neurodegenerative disorders that affect humans and certain animals and are caused by prions. In most cases, infection occurs by ingestion of prions. Their long-time persistence in the environment creates a reservoir of potentially infectious matter that renders the eradication of the disease problematic. Unfortunately, no cure is available to date. Yet, for both the treatment of infected and the protection of uninfected individuals, active and passive immunizations have been shown to have a beneficial effect on the course of the disease. The current review provides an overview of such antibody-based approaches and assesses their feasibility and potential in prophylaxis and therapy of transmissible spongiform encephalopathies.
Differential effects of urethan on the transcriptional activity of chromatin from regenerating liver. (1974)

Summary The effects of urethan, administered to male rats at various times after partial hepatectomy, on the capacity of soluble chromatin to serve as a template in vitro for Escherichia coli RNA polymerase were measured. The ability of a single i.p. dose of 1 mg of urethan per g to alter the in vitro transcriptional activity of chromatin isolated from regenerating liver was dependent upon the time after the removal of 70% of the liver at which urethan was administered. The carcinogen had no detectable effect on the ability of chromatin to serve as a template for RNA synthesis, as measured by the incorporation of both adenosine triphosphate- 14 C and guanosine triphosphate- 3 H into RNA, when the tissue was exposed to urethan during the prereplicative phase of liver regeneration. However, when urethan was injected 18 hr postsurgery and the chromatin was isolated 27 to 28 hr later, the template activity of these preparations measured by maximum reaction velocities was depressed 35% as evaluated by the quantity of adenosine monophosphate incorporated and 60% as determined by the amount of guanosine monophosphate utilized. The results indicate that the genome is preferentially susceptible to the action of urethan during the period of DNA replication and that the product of RNA polymerase transcribed from urethan-altered chromatin is rich in adenosine monophosphate relative to guanosine monophosphate.
Exploiting dominant eigendirections for feedback compression for FDD-based massive MIMO systems (2016)

Acquiring reliable channel state information (CSI) at the basestation is crucial to fully exploit the advantages of massive multiple-input multiple-output (MIMO) systems. However, giving the basestation knowledge of the downlink channel is an important and challenging problem in frequency division duplexing (FDD) systems when the number of basestation antennas is large. In this paper, we propose an eigenvalue decomposition based feedback compression (EFC) framework that transforms the channel information for pursuing further reduction in feedback overhead. The main idea of EFC is to use the compressed channels for generating short-term CSI by exploiting the dominant eigendirections of long-term channel-statistical information. By using the proposed codebook, each user terminal sends the compressed channel information as short-term feedback and channel-statistical information as long-term feedback. Numerical results demonstrate that the proposed method achieves significant feedback overhead reduction over the conventional beamforming techniques under the same target sum rate requirement.
Influence of intraperitoneal administration of tetanus toxin on experimental seizures and protection afforded by some antiepileptic drugs in mice (1999)

Our report aimed at describing the effects of the peripheral administration of tetanus toxin (Tetx) in clinically relevant doses on the functions of the central nervous system (CNS) in order to differentiate them with the consequences of central toxin administration. Tetx injected intraperitoneally (i.p.) evoked death in 50% of mice (LD50) at 11.0 (3.8-14.6) minimal lethal doses/kg (MLD/kg). Tetx (0.2/0.5 and 1.0 LD50) increased the convulsant thresholds of electric current 24-144 h post-treatment. Tetx (0.5 LD50) applied 48/120 h before the tests, attenuated the potency of chemical convulsants, increasing protection by antiepileptics in maximal electroshock, without affecting their total plasma levesl, γ-aminobutyric acid concentration (GABA) and total L-glutamic acid decarboxylase-activity (GAD) in brain homogenates-results similar to obtained after intracerebroventricular (i.c.v.) Tetx (15). These effects imply a preponderance of inhibitory over excitatory transmission, due probably to Tetx action at neuronal level. It indicates that Tetx penetrating into the central nervous system after i.p. injections evoke changes similar to those subsequent to i.c.v. Tetx administration, hinting that the two routes can have comparable predictive value in describing Tetx-induced changes in convulsive thresholds.
Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation (2019)

Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role in maintaining tissue architecture. Considering these critical functions, it is not surprising that adherens junctions are frequently involved in disease. In the present study, the effects of bile duct ligation-a surgical procedure to experimentally induce cholestatic and fibrotic liver pathology-on hepatic adherens junctions were investigated in mice. In essence, it was found that liver mRNA and protein levels of E-cadherin, β-catenin and γ-catenin drastically increase following bile duct ligation. These results could suggest a cytoprotective role for hepatic adherens junctions following bile duct ligation.
Laboratory Tests of a Theory of Fingering during Infiltration into Layered Soils (1990)

Abstract A theory has recently been presented by Hillel and Baker to explain and predict the occurrence of fingering and the fractional wetted volume during infiltration into layered soils in terms of measurable hydraulic properties. When the conductivity of a coarse‐textured sublayer at its effective water‐entry suction is greater than the rate of transmission through a finer‐textured top layer, the flow velocity increases across the interlayer plane. Thereupon, a spatially‐distributed flow field in the top layer will tend to constrict, forming spatially separated streams (fingers) in the sublayer. To test the hypothesis, ponded infiltration experiments were conducted in transparent laboratory chambers packed with air‐dry sands. The hydraulic properties of the media were determined by equilibrium capillary rise, parameter estimation, and horizontal absorption experiments. Dynamic measurements of flux and suction at the interlayer plane during infiltration revealed that the effective water‐entry suction is characteristic of the predominant pore size in the sublayer and can be predicted from its median particle size ( r 2 = 0.99). Predictions regarding the onset of fingering and the wetted fractional volume of fingers were both validated for the monodisperse and polydisperse sublayers studied.
Contemporary Logic and Evolutionary Taxonomy: A Reply to Gregg (1969)

Journal Article Contemporary Logic and Evolutionary Taxonomy: A Reply to Gregg Get access David L. Hull, David L. Hull Philosophy Department, The University of Wisconsin-MilwaukeeMilwaukee, Wisconsin 53201 Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Paul Snyder D. Paul Snyder Philosophy Department, Temple UniversityPhiladelphia, Pennsylvania 19122 Search for other works by this author on: Oxford Academic PubMed Google Scholar Systematic Biology, Volume 18, Issue 3, September 1969, Pages 347–354, https://doi.org/10.2307/2412333 Published: 01 September 1969