gebhart/patrepeval huggingface dataset:
Rapid-Swept CW Cavity Ring-down Laser Spectroscopy for Carbon Isotope Analysis (2006)

With the aim of developing a portable system for an in field isotope analysis, we investigate an isotope analysis based on rapid-swept CW cavity ring-down laser spectroscopy, in which the concentration of a chemical species is derived from its photo absorbance. Such a system can identify the isotopomer and still be constructed as a quite compact system. We have made some basic experimental measurements of the overtone absorption lines of carbon dioxide (12C16O2, 13C16O2) by rapid-swept cavity ring-down spectroscopy with a CW infrared diode laser at 6,200 cm−1(1.6)mm). The isotopic ratio has been obtained as (1.07±0.13)x 10−2, in good agreement with the natural abundance within experimental uncertainty. The detection sensitivity in absorbance has been estimated to be 3x 10−8cm−1.
Prinzmetal's angina, normal coronary arteries and pericarditis. (1978)

Spinel ferrites are commercially important because of their excellent magnetic and catalytic properties. The study by Low Energy Ion Scattering (LEIS) can reveal atomic scale information on the surface. The surface of selected spinel ferrites was investigated by LEIS. It has been found that it is the octahedral sites which are preferentially exposed on the surface of the spinel ferrites. So the probable planes which are exposed on spinel ferrite surfaces are D(110) or B(111). This prediction using LEIS gives scope for tailor-making compounds with catalytically active ions on the surface for various catalytic reactions.
A Tool and Method of Preparing Razor Blade Fragments for Microsurgery (1983)

A different type of cutting tool can be used to prepare fragments of stainless steel razor blades for microsurgery. The tool can be used to cut even flexible, extremely thin, unbreakable razor blades to any size, shape, or tip angle.
Surveillance of multi-drug resistance phenotypes in Staphylococcus aureus in Japan and correlation with whole-genome sequence findings (2022)

Tracking distinct resistance profiles deepened our understanding of the overall decrease in MRSA and led to recognition of the emergence of a new resistance phenotype. This study provides a model for future epidemiological research on antimicrobial resistance correlating multi-drug resistance phenotypes with selective genome sequencing, which can be applied to other bacterial species.
Adhesion Properties of Copper/Polyimide Film Modified by Reactive Ion Etching(RIE) (2007)

Surface modification of polyimide(PI) films was treated with oxygen RIE by varying ion doses from 1x1016 to 1x1018 ions/cm2 at an ion beam energy of 250 eV. Following the modification of PI surface, metal films consisting of NiCr/Cu and Cu were deposited on modified PI films by D.C. magnetron sputtering and electroplating, respectively. The surface modified PI film was characterized by XPS, AFM, SEM and contact angle measurement, respectively. The water contact angle of PI film decreased significantly from 64° to 4.4° with an increase of ion dose, indicating that the surface energy of PI film increased. The XPS spectrum showed that functional group, particularly C-O bonding, on modified PI surface was significantly increased by interaction between scissored unstable chains and reactive ions. The modified PI film surfaces by oxygen RIE showed significant improvement in adhesion to a overcoated metal film of NiCr/Cu.
Level Up, My-Pet: The Effects of Level-up Mechanism of Educational Agents on Student Learning (2013)

A number of studies have been devoted to investigating the influence of educational agents on different aspects of student learning. However, little attention has been paid to the effects of the level-up mechanism of educational agents on students although this is a significant issue. Thus, this study develops an educational agent with the level-up mechanism so that the effects of the level-up mechanism can be addressed. The results of a within-subject experiment conducted in an elementary school showed that the level-up mechanism of the educational agents can help students develop a positive relationship with the educational agent, and further enhance their motivation in terms of attention, relevance, and satisfaction.
Effects of extremely low concentrations of hormones on the insulin binding of Tetrahymena (2006)

FITC-insulin binding to previously hormone-treated Tetrahymena was studied by flow cytometry and confocal microscopy. Hormones produced by Tetrahymena were chosen for study and the hormone concentrations were administered between 10(-6) and 10(-21)M for 30 min. Endorphin, serotonin and insulin significantly reduced the hormone binding however histamine did not influence it at all. Endorphin, serotonin and insulin were significantly effective down to 10(-18)M and the effect of insulin and endorphin suggest a similar mechanism. The results call attention to the efficacy of very low hormone concentrations, which can influence the hormone content (earlier experiments) and receptor binding capacity (present study) of a unicellular organism. This seems to be very important, as in wild (natural) conditions the dilution of signaling materials secreted by a water-living protozoan is very high. In addition, the results point to the selectivity of response, as not all of the hormones that deeply influence other physiological indices (e.g. histamine) have an effect on insulin content or insulin receptors.
Investigations of capacitively-coupled EEG electrode for use in brain-computer interface (2012)

In this paper, the preliminary investigation for application of capacitive electroencephalogram (EEG) measurement for brain-computer interface (BCI) is described. EEG was obtained by active electrodes that very high input impedance pre-amplifier circuit was mounted on the electrodes. This method enabled EEG measurements through hair without direct contact with scalp and conductive gel applications. The presented electrode was attached to the normal usual baseball cap for nonintrusive daily or long-term use. Subject wore electrode installed baseball cap and EEG signal was measured under experimental BCI paradigms such as alpha wave, steady-state visual evoked potential, P300, auditory steady-state response and motor imagery. The results showed that further studies are still required to apply capacitive sensing methods to clinical neurosciences, however, it can be concluded that steady of the art capacitive electrode technology can be used for engineering applications using current popular BCI paradigms.
Prospective gated chest tomosynthesis using CNT X-ray source array (2015)

Chest tomosynthesis is a low-dose 3-D imaging modality that has been shown to have comparable sensitivity as CT in detecting lung nodules and other lung pathologies. We have recently demonstrated the feasibility of stationary chest tomosynthesis (s-DCT) using a distributed CNT X-ray source array. The technology allows acquisition of tomographic projections without moving the X-ray source. The electronically controlled CNT x-ray source also enables physiologically gated imaging, which will minimize image blur due to the patient’s respiration motion. In this paper, we investigate the feasibility of prospective gated chest tomosynthesis using a bench-top s-DCT system with a CNT source array, a high- speed at panel detector and realistic patient respiratory signals captured using a pressure sensor. Tomosynthesis images of inflated pig lungs placed inside an anthropomorphic chest phantom were acquired at different respiration rate, with and without gating for image quality comparison. Metal beads of 2 <i>mm</i> diameter were placed on the pig lung for quantitative measure of the image quality. Without gating, the beads were blurred to 3:75 <i>mm</i> during a 3 <i>s </i>tomosynthesis acquisition. When gated to the end of the inhalation and exhalation phase the detected bead size reduced to 2:25 <i>mm</i>, much closer to the actual bead size. With gating the observed airway edges are sharper and there are more visible structural details in the lung. Our results demonstrated the feasibility of prospective gating in the s-DCT, which substantially reduces image blur associated with lung motion.
Thiasugars as Potential Glycosidase Inhibitor (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma (2013)

Lenalidomide has been linked to myelodysplastic syndrome (MDS) after autotransplants for myeloma. Total therapy trials (TT; TT2(-/+) thalidomide) and TT3 (TT3a with bortezomib, thalidomide; TT3b with additional lenalidomide) offered the opportunity to examine the contribution of these immune-modulatory agents to MDS-associated cytogenetic abnormalities (MDS-CA) and clinical MDS or acute leukemia ("clinical MDS/AL"). Of 1080 patients with serial cytogenetic studies, MDS-CA occurred in 11% and clinical MDS/AL in 3%. Risk features of MDS-CA included TT3b, age ≥65 years, male gender, levels of β-2-microglobulin >5.5 mg/L, and multiple myeloma relapse. Clinical MDS/AL occurred less frequently in the control arm of TT2 and more often with TT3a and TT3b. Since MDS-CA often antedated clinical disease, periodic cytogenetic monitoring is recommended. Larger CD34 quantities should be collected upfront as the risk of MDS could be reduced by applying higher CD34 doses with transplant. Thus, treatment, host, and myeloma features could be linked to MDS development after therapy for this malignancy. This trial was registered at www.clinicaltrials.gov: TT3A: NCT00081939, TT3B: NCT00572169.
Influence of L-sorbose on the location of Î²-glucosidase in Trichoderma pseudokoningii (1983)

The effect of l-sorbose on growth, morphology, cell wall composition and β-glucosidase location has been examined with Trichoderma pseudokoningii. Sorbose-grown cultures exhibited a longer lag phase, a tendency to more frequent hyphal branching and showed a decreased cell wall content of β-1,3-glucan. In sorbose-containing cultures, a significant higher portion of total β-glucosidase was present in the culture fluid, whereas in sorbose-lacking control cultures the major part of activity was associated with the cell walls. The results support the previous hypothesis (Kubicek, C.P. (1982) Arch. Microbiol. 132, 349–354) that β-1.3-glucan is involved in cell wall binding of β-glucosidase in Trichoderma pseudokoningii.
RED PIGMENT FORMATION BY INTERACTION OF MOLDS PART 2 TAXONOMICAL CHARACTERISTICS OF PENICILLIUM STRAIN L 9 (1962)

A strain of Penicillium which produces red pigments by interaction with a strain of Trichoderma was isolated and identified as P. verruculosum by its taxonomical characteristics. The strain was found to produce a considerably large amount (12 to 13%) of gluconic acid when grown, under constant shaking, in a liquid medium containing 4% glucose.While this mold does not form any pigment in its pure culture it causes a production of red pigments-both in the mycellia and in the culture medium -when grown together with some other molds, especially with Trichoderma L 6 which has also been isolated in our laboratory . It was found that the same phenomenon is brought about also by some other strains of P. verruculosum. The significance of the formation of pigments by interactions of two fungal strains, which has never been reported in the literature, was discussed.
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle. (1993)

The subcellular distribution of the Ca(2+)-release channel/ryanodine receptor in adult rat papillary myofibers has been determined by immunofluorescence and immunoelectron microscopical studies using affinity purified antibodies against the ryanodine receptor. The receptor is confined to the sarcoplasmic reticulum (SR) where it is localized to interior and peripheral junctional SR and the corbular SR, but it is absent from the network SR where the SR-Ca(2+)-ATPase and phospholamban are densely distributed. Immunofluorescence labeling of sheep Purkinje fibers show that the ryanodine receptor is confined to discrete foci while the SR-Ca(2+)-ATPase is distributed in a continuous network-like structure present at the periphery as well as throughout interior regions of these myofibers. Because Purkinje fibers lack T-tubules, these results indicate that the ryanodine receptor is localized not only to the peripheral junctional SR but also to corbular SR densely distributed in interfibrillar spaces of the I-band regions. We have previously identified both corbular SR and junctional SR in cardiac muscle as potential Ca(2+)-storage/Ca(2+)-release sites by demonstrating that the Ca2+ binding protein calsequestrin and calcium are very densely distributed in these two specialized domains of cardiac SR in situ. The results presented here provide strong evidence in support of the hypothesis that corbular SR is indeed a site of Ca(2+)-induced Ca2+ release via the ryanodine receptor during excitation contraction coupling in cardiac muscle. Furthermore, these results indicate that the function of the cardiac Ca(2+)-release channel/ryanodine receptor is not confined to junctional complexes between SR and the sarcolemma.
Classification of short time series in early Parkinson s disease with deep learning of fuzzy recurrence plots (2019)

There are many techniques using sensors and wearable devices for detecting and monitoring patients with Parkinson's disease (PD). A recent development is the utilization of human interaction with computer keyboards for analyzing and identifying motor signs in the early stages of the disease. Current designs for classification of time series of computer-key hold durations recorded from healthy control and PD subjects require the time series of length to be considerably long. With an attempt to avoid discomfort to participants in performing long physical tasks for data recording, this paper introduces the use of fuzzy recurrence plots of very short time series as input data for the machine training and classification with long short-term memory (LSTM) neural networks. Being an original approach that is able to both significantly increase the feature dimensions and provides the property of deterministic dynamical systems of very short time series for information processing carried out by an LSTM layer architecture, fuzzy recurrence plots provide promising results and outperform the direct input of the time series for the classification of healthy control and early PD subjects.
Synthesis, structural and conformational study of <i>N</i>‐β(or γ)‐acyloxyalkylnortropinones (1988)

Abstract A series of N ‐β(γ)‐acyloxyalkylnortropinones have been synthesized and studied by 1 H and 13 C nmr spectroscopy, and the crystal structure of N ‐[γ‐( p ‐chlorophenylcarbonyloxy)propyl]nortropinone 4 has been determined by X‐ray diffraction. The compounds studied display in deuteriochloroform solution the same preferred conformation. The pyrrolidine and piperidone rings adopt a flattened N‐8 envelope and distorted chair conformation, puckered at N‐8 and flattened at C‐3 respectively, with the N ‐substituent in axial position with respect to the piperidone ring. These results are in close agreement with that found for compound 4 in the crystalline state.
Antiproliferative effect of Pterogyne nitens on melanoma cells (2007)

As part of our program of bioprospecting for novel antitumor drug prototypes, twenty extracts and fractions obtained from Pterogyne nitens Tul. (Fabaceae, Caesalpinioideae) were screened for antiproliferative activity against B16F10 murine melanoma cells, by the MTT colorimetric assay. The strongest activity was found in EtOAc fractions from the flowers (IC50 = 0.35 µg/mL), fruits (IC50 = 0.34 µg/mL), leaves (IC50 = 0.33 µg/mL) and stems (IC50 = 0.29 µg/mL). Analysis by TLC and HPLC-DAD showed the presence of guanidine alkaloids, flavones and flavonols in the bioactive samples. Additionally, a phytochemical study of the EtOAc fraction of the stems afforded quercetin (1) and isoquercitrin (2), two flavonols with antiproliferative activity previously described in the literature. On the basis of these results, it can be concluded that P. nitens inhibits the growth of melanoma cells in vitro. Further investigations will be needed to assess the usefulness of the samples under study for the treatment of neoplasms and to characterize other bioactive compounds. Keywords: antiproliferative; Pterogyne nitens; Caesalpinioideae; melanoma; flavonoids; Fabaceae.
Induction of Mesoderm in <i>Xenopus laevis</i> Embryos by Translation Initiation Factor 4E (1994)

The microinjection of messenger RNA encoding the eukaryotic translation initiation factor 4E (eIF-4E) into early embryos of Xenopus laevis leads to the induction of mesoderm in ectodermal explants. This induction occurs without a stimulation of overall protein synthesis and is blocked by the co-expression of a dominant negative mutant of the proto-oncogene ras or a truncated activin type II receptor. Although other translation factors have been studied in vertebrate and invertebrate embryos, none have been shown to play a direct role in development. The results here suggest a mechanism for relaying and amplifying signals for mesoderm induction.
Progression of Corpus Callosum Atrophy in Alzheimer Disease (2002)

Measurement of corpus callosum size allows in vivo mapping of neocortical neurodegeneration in AD over a wide range of clinical dementia severities and may be used as a surrogate marker for evaluation of drug efficacy.
Phosphorylation by Protein Kinase CK2 Modulates the Activity of the ATP Binding Cassette A1 Transporter (2004)

In a previous characterization of the ABCA subfamily of the ATP-binding cassette (ABC) transporters, we identified potential protein kinase 2 (CK2) phosphorylation sites, which are conserved in eukaryotic and prokaryotic members of the ABCA transporters. These phosphorylation residues are located in the conserved cytoplamic R1 and R2 domains, downstream of the nucleotide binding domains NBD1 and NBD2. To study the possible regulation of the ABCA1 transporter by CK2, we expressed the recombinant cytoplasmic domains of ABCA1, NBD1+R1 and NBD2+R2. We demonstrated that in vitro ABCA1 NBD1+R1, and not NBD2+R2, is phosphorylated by CK2, and we identified Thr-1242, Thr-1243, and Ser-1255 as the phosphorylated residues in the R1 domain by mass spectrometry. We further investigated the functional significance of the threonine and serine phosphorylation sites in NBD1 by site-directed mutagenesis of the entire ABCA1 followed by transfection into Hek-293 Tet-Off cells. The ABCA1 flippase activity, apolipoprotein AI and AII binding, and cellular phospholipid and cholesterol efflux were enhanced by mutations preventing CK2 phosphorylation of the threonine and serine residues. This was confirmed by the effect of specific protein kinase CK2 inhibitors upon the activity of wild type and mutant ABCA1 in transfected Hek-293 Tet-Off cells. The activities of the mutants mimicking threonine phosphorylation were close to that of wild type ABCA1. Our data, therefore, suggest that besides protein kinase A and C, protein kinase CK2 might play an important role in vivo in regulating the function and transport activity of ABCA1 and possibly of other members of the ABCA subfamily.
Análisis del daño estructural en aceros extradulces. Su influencia en la conformación (1982)

EN ESTA TESIS SE ANALIZA EL DANO ESTRUCTURAL QUE SE DESARROLLA DURANTE LA CONFORMACION EN FRIO POR EMBUTICION DE LOS ACEROS EXTRADULCES. POR DANO ESTRUCTURAL SE ENTIENDE LA NUCLEACION CRECIMIENTO Y COALESCENCIA DE CAVIDADES (HUECOS) EN EL INTERIOR DEL METAL CONFORME PROGRESA LA DEFORMACION. EL DANO ESTRUCTURAL ESTA RELACIONADO CON EL CONTENIDO EN INCLUSIONES EN LOS ACEROS INVESTIGADOS. EL DANO ESTRUCTURAL TIENE LUGAR FUNDAMENTALMENTE POR DECOHESION ORIGINADO POR LA DEFORMACION EN LAS INTERFASES MATRIZ-INCLUSION. LA CONFORMACION DE LAS CHAPAS SE HA VERIFICADO EMPLEANDO EL ENSAYO HIDRAULICO DE EMBUTICION. EL ANALISIS DE LA NATURALEZA FORMA Y TAMANO DE LAS INCLUSIONES Y CAVIDADES SE HA LLEVADO A CABO EMPLEANDO TECNICAS DE METALOGRAFIA CUANTITATIVA (MICROSCOPIA OPTICA Y ELECTRONICA DE BARRIDO CON MICROSONDA ASONADA) Y BALANZAS PARA MEDIR LAS PERDIDAS DE DENSIDAD DE ELEVADA PRECISION.
Color myocardial perfusion images derived from ultrafast CT compared to tracer microspheres (1988)

The use of ultrafast CT (computed tomography) to measure myocardial blood flow accurately has been recently demonstrated. A significant problem was found in identifying myocardial ischemia with traditional monochrome visualization. A pseudocolor display algorithm has been developed for myocardial perfusion visualization. The authors attempt to validate the color coding algorithm by comparing the amount of ischemia as measured by ultrafast CT and radioactive tracer microspheres using flow histograms of both techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Sagrera Martin I. — Sociologia de la sexualidad. II. Control natal y revolucion. III. Sadomasoquismo y sociedad (1976)

Hecht Jacqueline. Sagrera Martin I. — Sociologia de la sexualidad. II. Control natal y revolucion. III. Sadomasoquismo y sociedad. In: Population, 31ᵉ année, n°6, 1976. p. 1330.
An Investigation of the Thermoluminescence of Fluorite Colored by X-Ray Irradiation (1953)

The thermoluminescence resulting when calcium fluoride crystals colored by x-ray irradiation are heated, has been investigated in the region from 3200 to 6500A. First, the form of the emission spectrum was determined by the use of a spectrophotometer in conjunction with a photomultiplier tube as a detector, and fifteen emission bands were observed of which seven weak ones had not previously been reported. The peaks of these bands occurred at 3430, 3650, 3710, 3790, 3810, 4150, 4270, 4370, 4570, 4780, 4890, 5230, 5350, 5430, and 5740A. Second, continuous annealing curves or ``glow curves'' were obtained for the strongest emission bands by raising the temperature of the crystal at a constant rate and recording the intensity of the emitted light at the peak of each band. The maxima of the glow curves thus recorded fall into two groups. In group 1, three maxima located at approximately 197, 285, and 310°C were observed. In group 2, five intensity maxima could be distinguished, the lowest occurring at approximately 70°C and the highest at 245°C. The corresponding activation energies were calculated, and in two cases were checked by carrying out the annealing at fixed temperatures. These results are consistent with the assumption that two distinct types of imperfections are responsible for the thermoluminescence of calcium fluoride. The optical absorption appears to be the result of the imperfections associated with group 2.