gebhart/patrepeval huggingface dataset:
IC‐P‐044: LONGITUDINAL MONITORING OF β‐AMYLOID PATHOLOGY AND CEREBRAL HYPOMETABOLISM IN A DOUBLE TRANSGENIC MOUSE MODEL OF ALZHEIMER'S DISEASE (2014)

μPET imaging can be employed in animal models of Alzheimer's Disease to longitudinally monitor the time course of multiple pathogenic processes, their interrelations and their response to pharmacological interventions in the present study we aimed to investigate the progression of β-amyloid deposition and altered cerebral metabolism in double transgenic TASTPM mice. μPET imaging was conducted using a Siemens Inveon PET/CT system. PET data (wild-type n=22, TASTPM n=22) was acquired longitudinally with baseline scans at 3 months of age with follow-up scans at 6, 9 and 12 months. 20 min static scans were acquired after intravenous tracer injection (∼ 18 MBq) and a conscious uptake period of 30 and 45 min for [18 F]-AV45 and [18 F]-FDG respectively. Tracer uptake was quantified as a percentage of injected dose per tissue volume (%ID/g) for [18 F]-AV45 with additional normalization for pre-scan blood glucose levels for [18 F]-FDG (%IDglu). At each time point a subset of mice were examined histologically for amyloid burden (n=3 per genotype). TASTPM mice demonstrate subtle reductions in [18 F]-FDG uptake in relation to WT starting at 6 months becoming more prominent by 9 months with the most significant differences revealed in the thalamus (p=0.0044). While immunohistochemistry demonstrated progressive β-amyloid pathology initiating at 6 months in TASTPM mice, increased retention of [18 F]-AV45 in these animals versus WT was only apparent at 12 months with the cortex and hippocampus exhibiting the most significance (p<0.0001).
A 32x32 50ps Resolution 10 bit Time to Digital Converter Array in 130nm CMOS for Time Correlated Imaging (2024)

We report the design and characterisation of a 32x32 time to digital (TDC) converter plus single photon avalanche diode (SPAD) pixel array implemented in a 130nm imaging process. Based on a gated ring oscillator approach, the 10 bit, 50m m pitch TDC array exhibits a minimum time resolution of 50ps, with accuracy of ±0.5 LSB DNL and 2.4 LSB INL. Process, voltage and temperature compensation (PVT) is achieved by locking the array to a stable external clock. The resulting time correlated pixel array is a viable candidate for single photon counting (TCSPC) applications such as fluorescent lifetime imaging microscopy (FLIM), nuclear or 3D imaging and permits scaling to larger array formats.
Auto-Tuning, Adaptation and Expert Control (1985)

The paper addresses some key problems that arise in applications of adaptive control to industrial processes, prior knowledge, design based on simplified models, initialization and start up. Different ways of solving the problems are discussed. A new technique for automatic tuning of simple control loops is presented. The method has the advantage of automatically generating test signals whose properties are tuned to the process. A novel approach to the adaptive problem is proposed where an expert system orchestrates auto-tuning, conventional adaptive control, on-line diagnosis, and table based gain scheduling.
OS01F021 Electronic Speckle Pattern Interferometry with Optimum Image Extraction for Deformation Measurement under Environmental Disturbance (2011)

A method for extracting optimum images from a large amount of speckle images is proposed for ESPI measurement under environmental disturbance. During the measurement of static deformation under environmental disturbance, optimum images which can make interference fringes are extracted from the speckle images before the image subtraction. The extraction is based on the evaluation of the highest speckle contrast in time series value. The validity of the method is investigated by experiments under the environmental disturbance coming from the floor. Results indicate that the extraction method is effective and it is possible to measure static surface deformation by ESPI without a vibration isolator under environmental disturbance.
SystemVerilog Assertions: Past, Present, and Future SVA Standardization Experience (2012)

This paper provides insight into the development of System Verilog Assertions standardization efforts. Specifically it covers the evolution from Accellera 3.1a version to its current state of standardization (the upcoming SVA2012 release). Insight into the new features, changes and the reasons for the same exposes users of SVA to the direction the standard is evolving.
Tripolymers from Butyl Rubber Polymerization (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTripolymers from Butyl Rubber PolymerizationL. S. Minckler Jr. and A. B. SmallCite this: Ind. Eng. Chem. Prod. Res. Dev. 1962, 1, 3, 216–220Publication Date (Print):September 1, 1962Publication History Published online1 May 2002Published inissue 1 September 1962https://pubs.acs.org/doi/10.1021/i360003a018https://doi.org/10.1021/i360003a018research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Detection ofSalmonella Serovars fromClinical Samples by Enrichment BrothCultivation-PCR Proceduret (1994)

PCR-hybridization assaytospecifically identify Salmonella serovars fromclinical samples ofvarious animal species. Thetechnique wasinvestigated byusing fecal samples seeded withknownnumbersofSalmonella organisms andcultivated fordifferent lengths oftimeinassorted selective andnonselective enrichment media. Theability ofPCRtoamplify aSalmoneUla-specific DNA product (457-bp sequence covering theSalmonella invEandinvAgenes) wasexamined inSouthern hybridizations with aninternal oligonucleotide probe. Forty-seven Salmonella isolates representing 32serovars wereevaluated, and allSalmonella isolates resulted ina457-bp product thathybridized withtheoligonucleotide probe, whereas no hybridizations wereevident with53non-Salmonela organisms. Theassaydetected asfewas9 CFU of Salmonella organisms inpureculture andaslittle as300fgofpurified chromosomal DNA.RappaportVassiliadis andtetrathionate broths wereinhibitory toPCR,whereas brain heart infusion andselenite-cystine broths werenot.ThePCR-hybridization assaycoupled witha brainheartinfusion enrichment culture incubated for2hdetected asfewas80CFU ofSalmonella organisms inseeded feces. We havesuccessfully identified Salmonella serovars inclinical samples fromswine, horses, andcattle morerapidly thanwith conventional culture techniques. Thesensitivity andspecificity ofthisassay wereboth100lo compared with culture results. Theseresults indicate thata combined cultivation-PCR-hybridization assaycouldbe applicable andadvantageous intherapid identification ofSalmonella serovars inroutine diagnostic situations. Salmonellosis isoneofthemostcommoninfectious diseases intheworld inbothhumansandanimals. Salmonella infections canbemanifested inthree forms: gastroenteritis, involving an abrupt onsetofnausea, fever, vomiting, anddiarrhea; enteric fever (typhoid fever), usually caused bySalmonella typhi; and septicemia, characterized byfever, chills, anorexia, anemia, andfocal lesions onvisceral organs (7). Chronic asymptomatic carriers often arise fromapopulation infected withSalmonella serovars, andthedifficulty indetecting carriers byculture techniques makesthemapotential source ofenvironmental contamination (36).
The Force-Deflection Behavior of Functionally Graded Piezoceramic Actuators (2005)

Functionally Graded Piezoceramics (FGP) overcome the current reliability limitations within laminated piezoceramic actuators by eliminating the bond lines and stress discontinuities and lowering the overall internal stress levels. New fabrication methods for FGP, such as the Dual Electro/Piezo Property (DEPP) gradient technique, synergistically couple variations in permittivity and piezoelectric properties yielding more electrically efficient actuators capable of larger displacements. Unfortunately, such FGP approaches naturally introduce complexity into the electric field, stress, and material profiles, making it more difficult to model their performance. This paper develops a Hamiltonian energy-based modeling approach that fully captures the force-deflection performance of a generic multidimensionally graded piezoceramic actuator. As demonstration of the approach, two differently graded beams are presented: a two layered gradient that maximizes deflection and a linear gradient that minimizes internal stresses. DEPP graded prototypes were fabricated with a powder-pressed method for the two-layered specimen and microfabrication via co-extrusion for the linear gradient. The force-deflection performance of each cantilevered prototype under tip loading conditions was experimentally and numerically validated. The derived analytic model correlates very well with the observed behavior by incorporating the complex electric field variation and continuous stress distribution within the prototype eluded by conventional modeling methods. This comprehensive quasi-static force-deflection model provides designers with an effective and necessary tool for the implementation of FGP as actuators with extended service lifetimes.
In‐source fragmentation and analysis of polysaccharides by capillary electrophoresis/mass spectrometry (2005)

In order to develop a robust and easy-to-use technique for characterization of bacterial polysaccharides, a pseudo-hydrolysis strategy was investigated. Based on in-source collision-induced dissociation, polysaccharide molecular ions were fragmented within the orifice-skimmer region of an electrospray ionization (ESI) mass spectrometer. The fragment ions thus generated were then analyzed similarly to the conventional ESI mass spectrometry approach. MS/MS scanning was applied to obtain product-ion spectra of the primary fragments for sequencing. To further improve the sensitivity and separation of polysaccharides from other components in the samples, a pressure-assisted capillary electrophoresis/mass spectrometry (CE/MS) system was employed. Using bacterial polysaccharides as model compounds, the mass spectra obtained for polysaccharide repeating units generated through chemical hydrolysis and in-source fragmentation were directly compared, both in positive and negative ion modes. With the additional separation of impurities provided by CE, the success of this technique has been demonstrated for structural analysis of O-chain polysaccharides (O-PS) and capsular polysaccharides (CPS). In-source fragmentation was applied to promote the formation of structurally relevant repeating units of heterogeneous CPS that would remain undetected using conventional ESI conditions. This approach was proven to be particularly useful for probing the subtle structural differences in monosaccharide composition and functionalities arising across bacterial serotypes.
Transparent Birefringence-free Copolymer and its Application (1995)

The birefringence-free copolymer was prepared by randomly copolymerizing positive and negative birefringent monomers. The birefringence-free copolymer showed excellent transparency and no microscopic heterogeneous structures were observed. As a novel application of the birefringence-free copolymer, we propose the polarization preserving polymer optical fiber (POF).
ChemInform Abstract: TETRAKIS(METHYL ISOCYANIDE)PALLADIUM(II) TETRAKIS(7,7,8,8‐TETRACYANO‐P‐QUINODIMETHANE), (PD(CNME)4)(TCNQ)4.2MECN‐ SYNTHESIS, STRUCTURE, AND PHYSICAL PROPERTIES (1976)

Abstract 2 MeCN: Synthesis, Structure, and Physical Properties.
ChemInform Abstract: A FACILE ROUTE TO 1,3,5,7‐TETRAAMINOADAMANTANE. SYNTHESIS OF 1,3,5,7‐TETRANITROADAMANTANE (1981)

Abstract Aus Adamantan entsteht das Tetrabrom‐Derivat (Ia), das zum Tetraiodid (Ib) austauscht und dann nach Ritter unter photolytischer Beschleunigung mit Acetonitril das Amid (Ic) liefert.
A multi-step approach in anti-calcification of glutaraldehyde-preserved bovine pericardium. (2006)

In conclusion, results demonstrate that the multi-step anticalcification process improved the material stability and reduced the calcification potential of bovine pericardial tissue. These improvements in the quality of the bovine pericardium should enhance the long-term durability of the tissue as a bioprosthetic substitute for cardiovascular application.
Voluntary Alcohol Drinking Enhances Proopiomelanocortin Gene Expression in Nucleus Accumbens Shell and Hypothalamus of <scp>S</scp>ardinian Alcohol‐Preferring Rats (2012)

Our results define the distribution of POMC-expressing neurons in the NAc of mice and rats. Higher POMC expression at basal levels in sP rats (genetically determined), along with increases after drinking (alcohol-induced) in the NAc shell and hypothalamus, suggests that the POMC systems play a role in high alcohol preference and consumption.
Immunological Phenotype Analysis of Patients with Fanconi’s Anaemia and Their Family Members (1998)

In contrast to patients affected with Fanconi's anaemia (FA), who are homozygotes, parental heterozygotes are generally considered normal. In this preliminary work the main immunological phenotypes of circulating mononucleated cells were studied, both in homozygous and heterozygous subjects. The statistical analysis of results showed that two sets of variables may be distinguished: (a) the first set, including CD20, CD4, CD8 cell markers and CD20/CD3 and CD4/CD8 ratios, that was able to differentiate between FA patients and the other subject groups; (b) the second set, including CD25, HLA-DR, HLA-DP, HLA-DQ cell markers, that was able to differentiate healthy subjects from the other groups. Therefore, in contrast with the literature data, immunological abnormalities may already be present in parental heterozygotes of FA patients. These subjects displayed a reduced number of cells expressing both specific (CD25) and non-specific (HLA) antigens. This defect was more severe in FA homozygous patients, who showed, in addition, a reduced total lymphocyte count, reduced levels of T helper (CD4+) and B lymphocytes (CD20+), and a reduced CD4+/CD8+ cell ratio. In conclusion, our results suggest the presence of a grading of immunological defects in FA patients and family members. Our suggestion needs to be confirmed by functional studies.
Real-time issues of transputers in high performance motion control systems (machine control) (2002)

The design and implementation of a real-time kernel consisting of a multiple event handler and an efficient scheduler which improve the transputer's real-time performance is discussed. In addition to supporting high performance controller tasks, the real-time kernel implements features such as parameter sampling and user interaction is intended to be a platform to support a highly programmable and configurable controller suitable for a wide range of motion control applications. Test results are presented to show the performance of the kernel features.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Production and Evaluation of a Purified Adenovirus Group-Specific (Hexon) Antigen for Use in the Diagnostic Complement Fixation Test (1971)

A simple procedure for the production of large volumes of purified adenovirus group-specific complement-fixing (CF) (hexon) antigen by selective adsorption to and elution from CaHPO4 is described. Results of immunodiffusion tests, electrophoresis, electron microscopy, and tests for hemagglutination and infectivity indicate that the purified antigen consisted of a single virus component (hexon). The purified product contained little host materials. Unlike the crude virus harvest usually employed for serodiagnostic CF tests, the purified antigen demonstrated no anticomplementary activity and did not develop such activity during storage. The purified antigen was equal to or slightly more sensitive than crude virus harvests for serodiagnosis of adenovirus infections.
Development of antibodies against hydroxyatrazine and hydroxysimazine: application to environmental samples. [Erratum to document cited in CA119:153461] (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment of antibodies against hydroxyatrazine and hydroxysimazine: application to environmental samples. [Erratum to document cited in CA119:153461]Anne D. Lucas, Hassan K. M. Bekheit, Marvin H. Goodrow, A. Daniel Jones, Seth Kullman, Fumio Matsumura, James E. Woodrow, James N. Seiber, and Bruce D. HammockCite this: J. Agric. Food Chem. 1994, 42, 5, 1256Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/jf00041a040https://doi.org/10.1021/jf00041a040research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Beta-adrenergic modulation of pulmonary transvascular fluid and protein exchange (1986)

We determined in anesthetized sheep whether isoproterenol, a beta-adrenergic agonist, prevents the increases in pulmonary fluid and protein exchange produced by thrombin-induced intravascular coagulation. Seven sheep were infused intravenously with 0.05 micrograms X kg-1 X min-1 isoproterenol before infusion of alpha-thrombin, and six sheep were infused with alpha-thrombin only and served as control subjects. The marked increases in pulmonary lymph flow and lymph protein clearance in the control thrombin group were attenuated (P less than 0.05) in the isoproterenol group in association with a higher pulmonary blood flow (P less than 0.05) and a lower pulmonary vascular resistance (P less than 0.05) in the isoproterenol group and with similar increases in pulmonary arterial and pulmonary arterial wedge pressures in both groups. The decreases in fluid and protein fluxes produced by isoproterenol are related to its beta-adrenergic properties because propranolol, a beta-adrenergic antagonist, blocked the protective effects of isoproterenol in a second group of sheep infused with propranolol, isoproterenol, and thrombin. Raising left atrial pressure to test for changes in vascular permeability increased protein flux to a much greater extent in the thrombin control group than in the isoproterenol group challenged with thrombin. The data suggest that isoproterenol attenuated the increase in fluid and protein fluxes produced by thrombin-induced intravascular coagulation by a permeability-decreasing mechanism.
Formgebung von Titan und Titanlegierungen (2002)

Einleitung Spanen Gießen Schweißen Schmelzschweißen Reibschweißen Elektronenstrahlschweißen Laserstrahlschweißen Eigenschaften von Schmelzschweißverbindungen Superplastisches Umformen/Diffusionsschweißen Pulvermetallurgie Verwendete und weiterführende Literatur
EFFECTS OF NEUTRON BOMBARDMENT UPON THE PROPERTIES OF ZIRCONIUM AND OF A ZIRCONIUMTIN ALLOY (1953)

Changes in properties of unalloyed crystal bar zirconium and of a 2.5% tin-crystal bar zirconium alloy were determined after irradiations at process water temperatures in the MTR. Increases in electrical resistivity and in hardness were observed, which appeared to reach saturation values after sufficiently long exposures. The notch toughness of irradiated specimens were apparently somewhat improved after short exposures, but unchanged after longer exposures. (auth)
RELATIONSHIPS OF VARIOUS PHYSICAL AND CHEMICAL CHARACTERS TO DIGESTIBLE ENERGY IN WHEAT AND BARLEY CULTIVARS (1974)

Seventeen cultivars of hard and soft spring wheat (Triticum aestivum L.), and 29 cultivars of two-row and six-row barley (Hordeum distichum and H. vulgare) were examined for bulk weight (BW), 1,000-kernel weight (KW) and plumpness, and analyzed for gross composition, amylose, gross energy (GE), β-glucan (barley only), and for sedimentation (wheat only). Digestion coefficients and digestible energy (DE) values of the cultivars were determined by mouse-feeding. The ranges in protein, starch, amylose, and GE varied from 5 to 15%, whereas ether extract, fiber, ash and β-glucan contents varied from 1 to 3%. Except for sedimentation in wheat, and plumpness in barley there were no major differences in physical or chemical characters between hard and soft wheats or between two- and six-row barley. In wheat, DE was significantly correlated with BW (−0.59, P < 0.05), KW (−0.53, P < 0.05), plumpness (−0.55, P < 0.05), fiber (+0.72, P < 0.01), ash (−0.52, P < 0.05), sedimentation (−0.57, P < 0.05) and GE (+0.97, P < 0.01). Digestion coefficient was significantly correlated with protein (−0.58, P < 0.05), ash (−0.56, P < 0.05), and sedimentation (−0.57, P < 0.05). In barley, DE was significantly correlated with protein (+0.41, P < 0.05) and GE (+0.82, P < 0.01), and digestion coefficient was significantly correlated with BW (+0.55, P < 0.01), plumpness (+0.45, P < 0.05), ether extract (+0.50, P < 0.01), and fiber (−0.52, P < 0.01). For use as selection criteria the most significant correlations were between DE and GE and sedimentation in wheat, and between DE and GE in barley.