gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Diastereoselective Alkylation of 8‐Phenylmenthyl 2‐Methylacetoacetate. Preparation of Enantiomerically Pure 4,4‐Disubstituted 2‐Pyrazolin‐5‐ ones. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: SB‐219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp. Part 1. Fermentation, Isolation, and Properties. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Alterations in the Hypothalamic-Pituitary-Adrenal Axis in Metabolic Syndrome (2001)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login HomeCurrent IssuePrevious Issues Current Opinion in Endocrinology, Diabetes and ObesityThe Endocrinologist (1991 - 2010) Published Ahead-of-PrintFor Authors Information for AuthorsLanguage Editing Services Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and PermissionsMobileNew Features All Articles Images Videos Podcasts Blogs Advanced Search
Selective Modulation of Follicle-Stimulating Hormone Signaling Pathways with Enhancing Equine Chorionic Gonadotropin/Antibody Immune Complexes (2010)

The injection of equine chorionic gonadotropin (eCG) in dairy goats induces the production of anti-eCG antibodies (Abs) in some females. We have previously shown that Abs negatively modulate the LH and FSH-like bioactivities of eCG, in most cases, compromising fertility in treated females. Surprisingly, we found out that some anti-eCG Abs improved fertility and prolificity of the treated females, in vivo. These Abs, when complexed with eCG, enhanced LH and FSH ability to induce steroidogenesis on specific target cells, in vitro. In the present study, we analyzed the impact of three eCG/anti-eCG Ab-enhancing complexes on two transduction mechanisms triggered by the FSH receptor: guanine nucleotide-binding protein alphaS-subunit/cAMP/protein kinase A (PKA) and beta-arrestin-dependent pathways, respectively. In all cases, significant enhancing effects were observed on ERK phosphorylation compared with eCG alone. However, cAMP production and PKA activation induced by eCG could be differently modulated by Abs. By using a pharmacological inhibitor of PKA and small interfering RNA-mediated knock-down of endogenous beta-arrestin 1 and 2, we demonstrated that signaling bias was induced and was clearly dependent on the complexed Ab. Together, our data show that eCG/anti-eCG Ab-enhancing complexes can differentially modulate cAMP/PKA and beta-arrestin pathways as a function of the complexed Ab. We hypothesize that enhancing Abs may change the eCG conformation, the immune complex acquiring new "biased" pharmacological properties ultimately leading to the physiological effects observed in vivo. The modulation of ligand pharmacological properties by Abs opens promising research avenues towards the optimization of glycoprotein hormone biological activities and, more generally, the development of new therapeutics.
Clinical signs ofearly osteoarthritis: reproducibility andrelation toxraychanges in541womeninthe general population (1991)

Thedefnition andclassification ofearly clinically apparent osteoarthritis bothinclinicalsituations andinepidemiological surveys remains aproblem. Fewdataexist onthe between-observer reproducibility ofsimple clinical methods ofdetecting handandknee osteoarthritis inthepopulation andtheir sensitivity andspecificity ascompared with radiography. Twoobservers first studied thereproducibility ofanumberofclinical signs in41middle agedwomen.Goodrates ofagreement were foundformostoftheclinical signs tested (kappa=054-1-0). The morereproducible signs werethentested onapopulation of541 women,aged45-65, drawnfromgeneral practice, screening centres, andpatients previously attending hospital fornonrheumatic problems. Themajor clinical signs usedhada highspecificity (87-99%) and lowersensitivity (20-49%) whencompared withradiographs graded on theKeligren andLawrence scale(2+=positive). When analysis wasrestricted tosymptomatic radiographic osteoarthritis, levels ofsensitivity wereincreased andspecificity waslowered. Thesedatashowthat certain physical signs ofosteoarthritis arereproducible andmaybe usedtoidentify clinical disease. Theyarenot a substitute forradiographs, however, if radiographic change isregarded asthe'gold standard' ofdiagnosis. Astheclinical signs tested seemedspecific forosteoarthritis they maybeofvalue inscreening populations for clinical disease.
17% efficient thin film silicon solar cell by liquid phase epitaxy (2002)

Thin film silicon solar cells are attracting considerable interest as a possible means of achieving low cost while maintaining moderate to high cell efficiencies. In this paper we report on the results of our work to fabricate high efficiency cells on single crystal epitaxial layers. We use liquid phase epitaxy (LPE) to grow epitaxial layers of 30-50 /spl mu/m thickness on heavily doped CZ substrates. Solar cells fabricated on these layers have displayed efficiencies up to 17.0%. A key factor in obtaining these high efficiencies is the incorporation of effective light trapping into the cell structure. This is achieved by removing most of the substrate after cell processing.
A demand driven access protocol for high speed networks (2003)

A demand driven access (DDA) protocol for fiber-optic slotted rings is presented. The proposed protocol is simple and distributed. Under light load conditions, the protocol allows for efficient use of the available bandwidth since no overhead is incurred. In effect, the protocol is demand driven since access arbitration is only activated as the load increases in order to guarantee all nodes a maximum access delay. The protocol is designed for a counter-rotating dual-ring topology. Counter-rotating rings are required to carry backpressure control information in the opposite direction of the data flow. Furthermore, slots are freed at the destination node (as opposed to the source node). This considerably increases the potential throughput of the network. Simulation results demonstrate that for a ring a N nodes, given a uniform destination distribution, a maximum throughput of close to N/4 packets per slot time is achieved under heavy load conditions. Under these load conditions, the average access delay per packet is also on the order of N/4 slot times. The DDA protocol is shown to outperform FDDI both in terms of throughput and access delay.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Kinetics of Hydrolysis Reactions of Phenyltrichlorosilane (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of Hydrolysis Reactions of PhenyltrichlorosilaneJohn H. Cameron, Ted A. Kleinhenz, and Martin C. HawleyCite this: Ind. Eng. Chem. Fundamen. 1975, 14, 4, 328–333Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/i160056a009https://doi.org/10.1021/i160056a009research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Physicochemical and Pharmacokinetic Properties of Aprotinin–Polymer Conjugates in Mice (1998)

Aprotinin was conjugated with two biocompatible polymers—succinimidyl carbonate polyethylene glycol (PEG) and succinylated gelatin (Sue-gel). Some physicochemical and pharmacokinetic properties of both conjugates were characterized.



Mice were intravenously injected with radiolabelled native aprotinin, PEG-aprotinin and Suc-gel-aprotinin. Native aprotinin was found to be rapidly eliminated from systemic circulation (t½a = 2 min) and accumulated in the kidney within 5 min. In comparison, PEG- and Suc-gel-aprotinin conjugates were more retained in the blood (t½a = 8–10 min) and accumulated less in the kidney.



The results suggested that PEG-aprotinin may be more promising than Suc-gel-aprotinin for in-vivo application.
Meta heuristics for the orienteering problem (2003)

This paper presents two meta-heuristic techniques, ant colony optimization and tabu search, for the orienteering problem, a general version of the well-known traveling salesman problem with many relevant applications in industry. Both algorithms are compared to other heuristics in the literature. Results on 67 test problems show that the ant colony optimization method and tabu search method perform as well, or better, in all cases and do so at competitive computational cost.
Growth inhibition by cholera toxin of human lung carcinoma cell lines: correlation with GM1 ganglioside expression. (1992)

The effect of cholera toxin (CT) on the growth of 12 small cell lung carcinoma (SCLC) and 15 non-small cell lung carcinoma (NSCLC) cell lines is presented. CT inhibited the growth of nine SCLC cell lines (concentration for 50% inhibition of growth, 27-700 ng/ml), all of which had abundant expression of GM1 ganglioside, the surface receptor for CT. CT-resistant SCLC all had greatly decreased GM1 expression. In contrast, CT inhibited the growth of only four of 15 NSCLC cell lines. Seven of the 11 CT-resistant NSCLC had levels of GM1 comparable to CT-sensitive NSCLC or SCLC. In a limited panel of cell lines, cyclic AMP (cAMP) agonists including forskolin, 8Br[cAMP], and dibutyryl[cAMP] did not consistently reproduce CT-mediated inhibition of cell growth, nor did these compounds overcome resistance of cells to the growth inhibitory effects of CT. Expression of the RI and RII regulatory subunits of cAMP-dependent protein kinase was similar in CT-resistant and CT-sensitive SCLC or NSCLC cell lines. In the presence of isobutylmethylxanthine, intracellular cAMP levels induced by CT in a CT-resistant, GM1(+) NSCLC cell line were comparable to those achieved in a CT-sensitive NSCLC cell line. We conclude that inhibition of lung carcinoma cell growth by CT in all cases requires expression of GM1, and in the case of SCLC cell lines the presence of GM1 is sufficient. In NSCLC cell lines, expression of GM1 is not sufficient for growth inhibition by CT. These findings imply refractoriness to growth inhibition by cAMP in GM1(+), CT-resistant NSCLC cell lines and the possibility of non-cAMP-related mechanisms for growth inhibition in CT-sensitive cell lines.
Origin of XAS Resonances for 3D Metals in Rutile Compounds (1997)

In this work, we want to clear up the origin of the XAS structures for rutile compounds. To determine the connections between the atomic arrangement and XAS structures, we have calculated the Ti K edge in TiO 2 and compared results when few atoms are removed from the cluster. Multiple Scattering approach from FEFF6 code is used.
Differential Localization and Activity of the A- and B-Forms of the Human Progesterone Receptor Using Green Fluorescent Protein Chimeras (1999)

Subcellular localization and transcriptional activity of green fluorescent protein-progesterone receptor A and B chimeras (GFP-PRA and GFP-PRB) were examined in living mammalian cells. Both GFP-PRA and B chimeras were found to be similar in transcriptional activity compared with their non-GFP counterparts. GFP-PRA and PRA were both weakly active, while GFP-PRB and PRB gave a 20- to 40-fold induction using a reporter gene containing the full-length mouse mammary tumor virus long-terminal repeat linked to the luciferase gene (pLTRluc). Using fluorescence microscopy, nuclear/cytoplasmic distributions for the unliganded and hormone activated forms of GFP-PRA and GFP-PRB were characterized. The two forms of the receptor were found to have distinct intracellular distributions; GFP-PRA was found to be more nuclear than GFP-PRB in four cell lines examined. The causes for and implications of this differential localization of the A and B forms of the human PR are discussed.
Anthraquinone Losses During Alkaline Pulping (1984)

Extensive loss of anthraquinone (AQ) or the active catalyst anthrahydroquinone (AHQ) from the AQ –- AHQ catalytic cycle has been explained in part by side reactions leading to the reaction product anthrone (anthracen-9-one), followed by subsequent formation of adducts with lignin quinone methides. Degradation of an adduct between anthrone and the quinone methide of guaiacylglycerol-β-guaiacyl ether, under soda pulping conditions, resulted in a complex mixture of products. The mixture included 3-guaiacylbenzanthrone, bianthronyl, bianthrone, guaiacol, AQ, trans-coniferyl alcohol, trans-coniferylaldehyde, cis- and trans-1-(3-methoxy-4-hydroxyphenyl)-2-(2-methoxyphenoxy)ethene, vanillin, and 2-methoxy-4-vinylphenol. C-13 NMR studies of lignins isolated from soda/AQ spent liquors indicated the presence of residual anthrone adducts and a significant content of chemically attached AQ.
Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes (2010)

Hyperglucagonemia following oral glucose ingestion in patients with type 1 diabetes (and type 2 diabetes) has been claimed to result from impaired intraislet insulin inhibition of glucagon. We looked at plasma glucagon responses to the oral glucose tolerance test (OGTT) and isoglycemic intravenous glucose infusion (IIGI) in patients with type 1 diabetes. Nine patients without residual beta-cell function [age: 25 +/- 9 yr; body mass index (BMI): 24 +/- 2 kg/m(2); fasting plasma glucose (FPG): 9.5 +/- 2.1 mM; Hb A(1c): 8.4 +/- 1.2% (mean +/- SD)] and eight healthy subjects (age: 28 +/- 5 yr; BMI: 24 +/- 3 kg/m(2); FPG: 5.3 +/- 0.2 mM; Hb A(1c): 5.0 +/- 0.1%) were examined on two separate occasions: 4-h 50-g OGTT and IIGI. Isoglycemia during IIGIs was obtained using 53 +/- 5 g of glucose in patients with type 1 diabetes and 30 +/- 3 g in control subjects (P < 0.001), resulting in gastrointestinal-mediated glucose disposal [100% x (glucose(OGTT) - glucose(IIGI)/glucose(OGTT))] of -6 +/- 9 and 40 +/- 6% (P < 0.01), respectively. Equal glucagon suppression during the two glucose stimuli was observed in healthy subjects, whereas patients with type 1 diabetes exhibited less inhibition in response to OGTT compared with IIGI (AUC: 1,519 +/- 129 vs. 1,240 +/- 86 pM.4 h; P = 0.03). This difference was even more pronounced during the initial 40 min with paradoxical hypersecretion of glucagon during OGTT and suppression during IIGI (AUC: 37 +/- 13 vs. -33 +/- 16 pM.40 min; P = 0.02). These results suggest that the inappropriate glucagon response to glucose in patients with type 1 diabetes occurs as a consequence of the oral administration way, suggesting a role of the gastrointestinal tract, possibly via glucagonotropic signaling from gut hormones (e.g., glucose-dependent insulinotropic polypeptide), in type 1 diabetic hyperglucagonemia.
REDUCING VEHICLE TRIPS AND VEHICLE MILES OF TRAVEL THROUGH CUSTOMIZED TRAVEL OPTIONS (1999)

This project was designed to implement a new application to help reduce total vehicle trips and vehicle miles of travel by encouraging the use of trip-chaining and substitution for all types of trips. CUTR provided employees of a local YMCA with travel diaries and implemented a three-stage research design. 75 Individuals In 39 households participated. An analysis of covariance was conducted on the average contributed vehicle miles of travel and contributed vehicle trips, using the second week's results as the dependent variable. The provision of suggestions had a statistically significant effect on vehicle miles and trips contributed. Overall, this experiment showed that the provision of travel information will reduce vehicle miles of travel. Further research should be conducted to indicate the extent to which such information needs to be customized.
A case of intrahepatic biliary ductal adenoma coexisted with sigmoid carcinoma (2008)

症例は74歳，男性．平成19年1月血便，下腹部痛を主訴として当院に受診した．精査の結果，S状結腸癌と胆嚢結石症と診断され手術を施行した．術中，肝S8表面に径7mmの固い白色結節を認め，同時性肝転移を疑い，肝部分切除術を施行した．術後の病理組織学的検査では肝内の結節は周囲の肝組織とは境界明瞭で，被膜を形成せず，小型の腺管あるいは索状胞巣の構造を呈した胆管上皮細胞の増生と，その周囲の膠原線維の増生を伴い，肝内胆管腺腫と診断された．肝内胆管腺腫は胆管細胞由来の稀な良性上皮性腫瘍であり，本邦での報告例は自験例を含め検索しえた限りでは28例と稀な疾患であった．
Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice (2002)

The thyrotropin (TSH) receptor (TSHR) is a member of the heterotrimeric G protein-coupled family of receptors whose main function is to regulate thyroid cell proliferation as well as thyroid hormone synthesis and release. In this study, we generated a TSHR knockout (TSHR-KO) mouse by homologous recombination for use as a model to study TSHR function. TSHR-KO mice presented with developmental and growth delays and were profoundly hypothyroid, with no detectable thyroid hormone and elevated TSH. Heterozygotes were apparently unaffected. Knockout mice died within 1 week of weaning unless fed a diet supplemented with thyroid powder. Mature mice were fertile on the thyroid-supplemented diet. Thyroid glands of TSHR-KO mice produced uniodinated thyroglobulin, but the ability to concentrate and organify iodide could be restored to TSHR-KO thyroids when cultured in the presence of the adenylate cyclase agonist forskolin. Consistent with this observation was the lack of detectable sodium-iodide symporter expression in TSHR-KO thyroid glands. Hence, by using the TSHR-KO mouse, we provided in vivo evidence, demonstrating that TSHR expression was required for expression of sodium-iodide symporter but was not required for thyroglobulin expression, suggesting that the thyroid hormone synthetic pathway of the mouse could be dissociated into TSHR-dependent and -independent steps.
Preparation and surface‐ active properties of new amphipathic compounds with two phosphate groups and two long‐ chain alkyl groups (1991)

New compounds bearing two dihydrogen phosphate groups and two long‐ chain alkyl groups (octyl or decyl) were prepared in good yields by the reaction of 1,ω‐ bis (alkyloxymethyl)‐ oligo (ethylene glycol)s with polyphosphoric acid. Amphipathic di‐ or tetrasodium phosphates were obtained by neutralization of the free acids with sodium hydroxide, and their surface‐ active properties in water were measured. Almost all these di‐ or tetrasodium phosphates showed good water solubility. Their abilities to form micelles and to lower surface tension were fairly good as compared with general monoalkyl phosphates consisting of one longer alkyl chain and one hydrophilic group. The foaming property of aqueous solutions of the tetrasodium salts was different from that of the disodium salts. The former showed very low foaming ability.
Disinhibitory effects of LY354740, a new mGluR2 agonist, on behaviors suppressed by electric shock, in rats and pigeons (1997)

s of the BAP/EBPS International Workshop on The Behavioural Pharmacology of Anxiety and Depression, Bath, UK, November 20-23: PDF Only
A self-adaptive prioritised hand-off DCA strategy for a microcellular environment (2002)

A complete traffic model and analysis for microcellular mobile systems with handoff using fixed channel allocation (FCA) is described. Only the new call arrival rate is supposed to be known and a method of assessing the hand-off arrival rate in each cell for any kind of traffic is derived. The analytical method is validated with a real non-uniform traffic distribution and is verified by simulations. An extension to the nonuniform compact pattern allocation algorithm is presented as an application of this analysis. Based on this extended concept, we propose a modified version of a dynamic channel allocation (DCA) strategy called compact pattern with maximised channel borrowing (CPMCB). It is shown that CPMCB is now a self-adaptive prioritised hand-off DCA strategy with enhanced performance that can be exploited in a PCS environment. The effect of user mobility on the grade of service is also considered by CPMCB.
Analysis of the genetic diversity and phylogenetic relationship of Italian isolates of feline immunodeficiency virus indicates a high prevalence and heterogeneity of subtype B. (1997)

The genetic diversity of 32 Italian isolates of feline immunodeficiency virus (FIV) was studied. Isolates were obtained from domestic cats living in different areas. Sequence data were obtained from a 308 bp fragment of the p25 region of the gag gene. Phylogenetic relationships among these sequences and previously published sequences were determined. All the Italian isolates could be assigned to subtype B; however, four isolates formed two separate clusters and may represent genetic outliers. The reliability of classification results was confirmed by repeating the phylogenetic analysis with DNA sequences from the entire gag genes of two isolates and from the surface glycoprotein domain of the env gene of four isolates. It is concluded that the short segment of gag used permits reliable genotyping of FIV isolates. The study also shows that subtype B is largely prevalent in Italy.
Rejuvenation with workload migration (2010)

A five-state model of software rejuvenation is introduced that divides the working state into three sub-states: working, vulnerable, and preparing. The preparing state models the period during which workload is drained from software elements that are about to be rejuvenated. We compared our model to a four-state model that only has working and vulnerable sub-states.