gebhart/patrepeval huggingface dataset:
Controlled Imipramine Treatment of School Phobia (1971)

During a double-blind, placebo-controlled study, imipramine hydrochloride was administered to 35 nonpsychotic school-phobic children. The children and their families were given a multidiscipline treatment program, concurrently with imipramine or placebo treatment. Imipramine, administered over a six-week period, was found significantly superior to placebo in inducing school return, and in global therapeutic efficacy. Doses of medication ranged from 100 to 200 mg /day. Imipramine effects could not be detected after three weeks of therapy.
Final Report on LDRD Project: Heterogeneous Integration of Optoelectronic Arrays and Microelectronics (2003)

No abstract prepared.
Dibutyryl Adenosine Cyclic 3′:5′-Monophosphate Effects on Goldfish Behavior and Brain RNA Metabolism (1971)

Intraventricular administration of dibutyryl adenosine cyclic 3':5'-monophosphate into goldfish brains produced hyperactive animals. A study of the effects of the drug (25-50 mg/kg) on the incorporation of [5-(3)H] orotic acid, as a precursor of labeled uridine and cytidine, into newly synthesized RNA showed the formation of an RNA with a uridine to cytidine ratio 20-50% higher than that of the control. In double-labeling experiments with uridine as the labeled precursor, the synthesis of a nuclear RNA fraction (not produced in the absence of drug) was demonstrated. Some of this RNA was found to migrate into the cytoplasmic fraction and to become associated with polysomes. The results suggest that cyclic AMP might function as a "metabolic demand signal" for eliciting new RNA synthesis in goldfish brain.
Fully implicit three-dimensional MHD (magnetohydrodynamics) stability and evolution in toroidal geometry (1987)

The FAR family of computer codes has been developed at Oak Ridge National Laboratory to solve ideal and resistive, linear and nonlinear, 3-D full MHD problems in toroidal geometry. Extensive application of an incompressible version of these codes has been made to the linear stability of tokamaks and stellarators, and nonlinear studies have also been recently completed. Present work includes generalization of the physical model in several respects to incorporate the effects of compressibility, long mean free path, and thermal conductivity.
Role of the spleen on the immunosuppression in patients with gastric cancer and evaluation of splenectomy in their prognosis. (1988)

胃がん患者における脾の免疫抑制への関与と胃全摘例における脾摘の意義について検討した.脾細胞ではCD4+2H4+ (suppressor inducer T) 細胞の割合が高く, 脾静脈血リンパ球ではCD8+CD11+ (suppressor T) 細胞の割合が有意に高い事が認められた.胃がん全適例における術後7年目での累積生存率は, 特に進行がん症例では有意に脾摘群の予後が良好であった.脾摘群では, PPD皮内反応は術後の回復も早く, また血清抑制因子は明らかに低下した.胃がん患者脾はsuppressor T細胞誘導の場を担い, 免疫抑制に関与すると考えられ, さらに脾摘群で有意に予後が良好であることが認められた.
Genetic and Pharmacological Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Is Protective in Endotoxic Shock (2012)

Pharmacological and genetic reduction of DDAH1 activity is protective against the vascular changes observed during endotoxic shock.
Development of a Combinatorial Plasma Process Analyzer for Advanced R&D of Next Generation Nanodevice Fabrication (2010)

This chapter contains sections titled: Introduction Simulation Code Experimental Results and Discussion Summary
New additional cooling effect of diffusioncooled sealed-off CO<sub>2</sub> lasers excited by dielectric barrierdischarges at about 1 MHz with an all-solid-state generator (2004)

Diffusion cooled sealed-off CO 2 lasers excited by a dielectric barrier discharge with a developed all-solid-state generator. A homogeneous discharge of hf excitation at average electrical power density of up to 25 Wcm -3 is obtained without applying any stabilization techniques on the discharge at a discharge gap of d = 6 mm for the first time. A discharge gap of d = 6 mm is used to ensure a free propagation of the laser beam without any waveguide losses. A maximal output laser power of 70 W is attained with a laser efficiency of 8 % at an electrical power density of 20 Wcm -3 . A laser efficiency of 12.5 % is reached at an electrical input power of 10 Wcm -3 . Emission spectroscopy is used to measure the spatially resolved electron energy in the discharge gap at excitation frequencies between 0.4 and 2.4 MHz. It shows, that the mean electron energy lies in an efficient range to excite CO 2 lasers. An optical fibre thermometer is used to measure the gas temperature porfile inside the discharge gap. The measured gas temperature is 150 K below the theoretically calculated value. A additionally cooling effect is responsible for the low gas temperature.
Genotypic and Environmental Effects on Flour Properties in Korean Winter Wheat (2002)

Flour characteristics of Korean winter wheat grown in Suwon in 1997 and 1998, and in Suwon and Deokso in 1998 were evaluated. Korean winter wheat cultivars were significantly influenced by years and locations in flour properties such as ash content, protein content, damaged starch content, starch swelling volume and power. Protein content was highly correlated with starch damage and alkaline water retention capacity. There were highly significant correlations between mixing time of mixograph and SDS sedimentation volume. Swelling properties of flour and starch were highly correlated with pasting properties of flour and starch, respectively. Compared to commercial flours for baking, Alchanmil, Gobunmil, Keumkangmil and Tapdongmil showed similar protein content, SOS sedimentation volume and mixograph mixing time. Eunpamil, Geurumil, Olgeurumil, Suwon 258, Suwon 261, Suwon 265, Suwon 275, Suwon 276, Suwon 277, Suwon 278 and Urimil had similar values to commercial noodle flours in SDS sedimentation volume. Alchanmil, Olgeurumil, Suwon 274, Suwon 275, Suwon 276 and Urimil showed higher swelling and pasting properties than the others. Chokwang, Olgeurumil, Suwon 277 and Urimil were similar to commercial cookie flours. Friabilin-absence lines showed higher protein content and starch damage than those of friabilin-presence lines. Absence lines of 1D2.2 + 1Dy12 subunit in high molecular weight glutenin subunits showed higher SDS sedimentation volume and mixing time of mixograph than those of presence lines.
Some chemical and kinetic studies of crystalline papain (1955)

E. L. Smith, B. J. Finkle and A. Stockell, Discuss. Faraday Soc., 1955, 20, 96 DOI: 10.1039/DF9552000096
Synthetic Conditions for High-Accuracy Size Control of PbS Quantum Dots (2015)

Decreasing the variability in quantum dot (QD) syntheses is desirable for better uniformity of samples for use in QD-based studies and applications. Here we report a highly reproducible linear relationship between the concentration of ligand (in this case oleic acid, OA) and the lowest energy exciton peak position (nm) of the resulting PbS QDs for various hot-injection temperatures. Thus, for a given injection temperature, the size of the PbS QD product is purely controlled by the amount of OA. We used this relationship to study PbS QD solar cells that are fabricated from the same size of PbS QDs but synthesized using four different injection temperatures: 95, 120, 150, and 185 °C. We find that the power conversion efficiency does not depend on injection temperature but that the V(oc) is higher for QDs synthesized at lower temperatures while the J(sc) is improved in higher temperature QDs.
Nano Delivers Big: Designing Molecular Missiles for Cancer Therapeutics (2011)

Current first-line treatments for most cancers feature a short-list of highly potent and often target-blind interventions, including chemotherapy, radiation, and surgical excision. These treatments wreak considerable havoc upon non-cancerous tissue and organs, resulting in deleterious and sometimes fatal side effects for the patient. In response, this past decade has witnessed the robust emergence of nanoparticles and, more relevantly, nanoparticle drug delivery systems (DDS), widely touted as the panacea of cancer therapeutics. While not a cure, nanoparticle DDS can successfully negotiate the clinical payoff between drug dosage and side effects by encompassing target-specific drug delivery strategies. The expanding library of nanoparticles includes lipoproteins, liposomes, dendrimers, polymers, metal and metal oxide nano-spheres and -rods, and carbon nanotubes, so do the modes of delivery. Importantly, however, the pharmaco-dynamics and -kinetics of these nano-complexes remain an urgent issue and a serious bottleneck in the transition from bench to bedside. This review addresses the rise of nanoparticle DDS platforms for cancer and explores concepts of gene/drug delivery and cytotoxicity in pre-clinical and clinical contexts.
Generalized transformation optics of linear materials (2011)

We continue the development of a manifestly 4-dimensional, completely covariant, approach to transformation optics in linear dielectric materials begun in a previous paper. This approach, which generalizes the Plebanski based approach, is systematically applicable for all transformations and all general linear materials. Importantly, it enables useful applications such as arbitrary relative motion, transformations from arbitrary non-vacuum initial dielectric media, and arbitrary space-times. This approach is demonstrated for a resulting material that moves with uniform linear velocity. The inverse problem of this covariant approach is shown to generalize Gordon's "optical metric".
Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus. (1980)

An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys. This octacosapeptide possesses high somatotropin (growth hormone) and prolactin release-inhibiting activity in vitro. It also crossreacts strongly with antisera generated against the somatostatin tetradecapeptide. This octacosapeptide is most likely a precursor (pro-hormone) of somatostatin in the hypothalamus. The existence of still larger molecular size precursors of somatostatin was also observed.
State of the art 1.3 μm lasers by atmospheric pressure MOVPE using tertiary butylphosphine (1991)

Excellent 1.3 micrometre laser devices were realised for the first time with active light-emitting layers grown from the alternative phosphorous precursor TBP instead of phosphine. A wider temperature range than previously reported was explored for growth under TBP. The replacement of phosphine appears entirely feasible, albeit expensive.
Genetic and Epidemiologic Trends of Norovirus Outbreaks in the United States from 2013 to 2016 Demonstrated Emergence of Novel GII.4 Recombinant Viruses (2017)

Noroviruses are the most frequent cause of epidemic acute gastroenteritis in the United States. Between September 2013 and August 2016, 2,715 genotyped norovirus outbreaks were submitted to CaliciNet. GII.4 Sydney viruses caused 58% of the outbreaks during these years. A GII.4 Sydney virus with a novel GII.P16 polymerase emerged in November 2015, causing 60% of all GII.4 outbreaks in the 2015-2016 season. Several genotypes detected were associated with more than one polymerase type, including GI.3, GII.2, GII.3, GII.4 Sydney, GII.13, and GII.17, four of which harbored GII.P16 polymerases. GII.P16 polymerase sequences associated with GII.2 and GII.4 Sydney viruses were nearly identical, suggesting common ancestry. Other common genotypes, each causing 5 to 17% of outbreaks in a season, included GI.3, GI.5, GII.2, GII.3, GII.6, GII.13, and GII.17 Kawasaki 308. Acquisition of alternative RNA polymerases by recombination is an important mechanism for norovirus evolution and a phenomenon that was shown to occur more frequently than previously recognized in the United States. Continued molecular surveillance of noroviruses, including typing of both polymerase and capsid genes, is important for monitoring emerging strains in our continued efforts to reduce the overall burden of norovirus disease.
Effect of Kidney Cotransplantation on Induction of Heart Graft Tolerance in Nonhuman Primates (NHPs) (2012)

Introduction: Tolerance has been achieved in NHPs and human recipients of kidney allogeneic transplants through induction of transient hematopoietic mixed chimerism. However, the same approach has failed to induce tolerance of cardiac allografts in primates. In this study, we investigated whether immune regulation induced by kidney allografts in this model could spread to heart transplants from the same donor thereby preventing their rejection in cynomolgus monkeys. Methods: Cynomolgus monkeys underwent donor bone marrow transplantation (DBMT) and either heart/kidney co-transplantation (n=6) or heart transplant alone (n=4) following nonmyeloablative conditioning, which consisted of TBI (1.5 Gy ×2), thymic irradiation (7Gy), horse ATG, anti-CD154 mAb, and a 28-day course of cyclosporine. One monkey received DBMT 4 months after co-transplantation. Results: The majority of recipients of DBMT and co-transplantation of the heart and kidney achieved long-term survival (380*, 391*, >366, >261, 131, >51, >30 days; *[heart rejection after removal of the kidney on day 315]) of both allografts without maintenance immunosuppression. Critical involvement of the kidney allograft in the maintenance of tolerance was clearly demonstrated as heart allograft was rejected shortly after removal of the kidney allograft. In stark contrast, all four monkeys transplanted with an isolated heart acutely rejected shortly after cessation of Cyclosporine. IFNγ-ELISPOT and MLR assays in tolerant recipients showed donor specific hyporesponsiveness. T regulatory cells were found enriched in 7-8 times more in the kidney allograft comparing with those in the peripheral blood. Conclusion: This is the first demonstration of heart allograft tolerance in nonhuman primates. Apparently, the presence of the allogeneic kidney is necessary for the maintenance of tolerance of the transplanted heart. The mechanistic studies suggested that the kidney allograft facilitates to induce/expand specific regulatory T cells induced after transient mixed chimerism.Figure: [Cardiac Graft Survival]
Using Genetic Algorithm for Eye Detection and Tracking in Video Sequence (2007)

We propose a high-speed size and orientation invariant eye tracking method, which can acquire numerical parameters to represent the size and orientation of the eye. In this paper, we discuss that high tolerance in human head movement and real-time processing that are needed for many applications, such as eye gaze tracking. The generality of the method is also important. We use template matching with genetic algorithm, in order to overcome these problems. A high speed and accuracy tracking scheme using Evolutionary Video Processing for eye detection and tracking is proposed. Usually, a genetic algorithm is unsuitable for a real-time processing, however, we achieved real-time processing. The generality of this proposed method is provided by the artificial iris template used. In our simulations, an eye tracking accuracy is 97.9% and, an average processing time of 28 milliseconds per frame.
nab-Paclitaxel-Based Therapy in Underserved Patient Populations: The ABOUND.70+ Study in Elderly Patients With Advanced NSCLC (2018)

The phase 4 ABOUND.70+ trial assessed the safety and efficacy of <i>nab</i>-paclitaxel/carboplatin continuously or with a 1-week break between cycles in elderly patients with advanced non-small cell lung cancer (NSCLC). Patients ≥70 years with locally advanced/metastatic NSCLC were randomized 1:1 to first-line <i>nab</i>-paclitaxel days 1, 8, 15 plus carboplatin day 1 of a 21-day cycle (21d) or the same <i>nab</i>-paclitaxel/carboplatin regimen with a 1-week break between cycles (21d + break; 28d). The primary endpoint was the percentage of patients with grade ≥ 2 peripheral neuropathy (PN) or grade ≥ 3 myelosuppression. Other key endpoints included progression-free survival (PFS), overall survival (OS), and overall response rate (ORR). A total of 143 patients were randomized (71 to 21d, 72 to 21d + break). The percentage of patients with grade ≥ 2 PN or grade ≥ 3 myelosuppression was similar between the 21d and 21d + break arms (76.5 and 77.1%; <i>P</i> = 0.9258). Treatment exposure was lower in the 21d arm compared with the 21d + break arm. Median OS was 15.2 and 16.2 months [hazard ratio (HR) 0.72, 95% CI 0.44-1.19; <i>P</i> = 0.1966], median PFS was 3.6 and 7.0 months (HR 0.48, 95% CI 0.30-0.76; <i>P</i> < 0.0019), and ORR was 23.9 and 40.3% (risk ratio 1.68, 95% CI 1.02-2.78; <i>P</i> = 0.0376) in the 21d and 21d + break arms, respectively. In summary, the 1-week break between treatment cycles significantly improved PFS and ORR but did not significantly reduce the percentage of grade ≥ 2 PN or grade ≥ 3 myelosuppression. Overall, the findings support the results of prior subset analyses on the safety and efficacy of first-line <i>nab</i>-paclitaxel/carboplatin in elderly patients with advanced NSCLC.
Diarylpropionitrile (DPN) Enantiomers: Synthesis and Evaluation of Estrogen Receptor β-Selective Ligands (2011)

Two estrogen receptor (ER) subtypes, ERα and ERβ, mediate the actions of estrogens in diverse reproductive and nonreproductive target tissues. ER subtype-selective ligands, which bind to and activate these subtypes differentially, have proved to be useful in elucidating which actions of estrogens proceed through ERα vs ERβ. Some of these ligands show potential as novel therapeutic agents. Diarylpropionitrile (DPN), an ERβ selective ligand that we developed, is a chiral molecule, but it has been studied almost exclusively as the racemic mixture (rac-DPN, 1). Herein we report the development of an efficient enantioselective synthesis of the two isomers, R-DPN (3) and S-DPN (2), and we have compared the in vitro ligand binding affinities, coactivator binding affinities, recruitment potencies, and cellular transcriptional potencies of these isomers. Both enantiomers show a very high affinity and potency preference for ERβ over ERα, typically in the range of 80-300-fold. Although the enantioselectivity is only modest (3-4-fold), the R-enantiomer is the higher affinity and more potent isomer. While ERβ can be effectively and selectively stimulated by rac-DPN or by either R-DPN or S-DPN, R-DPN might be the preferred member of this isomeric series for biological studies of ERβ function.
Gene Therapy Applications for Spine Fusion (2003)

Gene therapy strategies for spine fusion are appealing because the setting is uniquely suited for genetic manipulation. The intervention is locally applied. Only a short duration of transgene response by the cells is necessary to establish a spine fusion, and a variety of osteoinductive growth factors have been identified and are available for use. Attempts at spine fusion using gene therapy in the lower animals have been successful using both in vivo and ex vivo approaches. Before human clinical trials can be established, further testing is required in more challenging animal models of bone induction such as nonhuman primates. Should a successful clinical program of gene therapy for spine fusion be established, the use of autograft and its associated morbidities could be eliminated. In fact, gene therapy offers the potential for minimally invasive applications that could bypass the need for an open procedure altogether. It is likely that gene therapy will be a powerful therapeutic tool for the spine surgeon in the new millennium.
Pattern matching with swaps (2002)

Let a text string T of n symbols and a pattern string P of m symbols from alphabet /spl Sigma/ be given. A swapped version T' of T is a length n string derived from T by a series of local swaps, (i.e. t/sup '//sub l//spl larr/t/sub l+1/ and t'/sub l+1//spl larr/t/sub l/) where each element can participate in no more than one swap. The Pattern Matching with Swaps problem is that of finding all locations i for which there exists a swapped version T' of T where there is an exact matching of P in location i of T'. It has been an open problem whether swapped matching can be done in less than O(mn) time. In this paper we show the first algorithm that solves the pattern matching with swaps problem in time O(mn). We present an algorithm whose time complexity is O(nm/sup 1/3/ log m log/sup 2/ /spl sigma/) for a general alphabet /spl Sigma/, where /spl sigma/=min(m, |/spl Sigma/|).
Relative Migratory Aptitude of Substituents and Stereochemistry of Dyotropic Ring Enlargements of β‐Lactones (1997)

Not concerted, but stepwise: Dyotropic ring enlargement of β-lactones 1 to γ-lactones 2 proceeds via the zwitterionic intermediate Z-1 (σ-and π-donor substituents). The relative migratory aptitude of the substituents is π-donor > n-donor > σ-donor.
Fatigue and Healing Characterization of Asphalt Mixtures (2003)

This paper investigates the effect of the processes on fatigue fracture and fracture healing during controlled-strain, dynamic mechanical analysis (DMA) testing. Sand asphalt samples were fabricated with two SHRP-classified binders: AAD-1 and AAM-1. DMA testing was performed at 25°C and at 10 Hz. The mechanical response during DMA testing was monitored using three different damage indicators: (1) change in dynamic modulus; (2) change in pseudo stiffness; and (3) change in dissipated strain energy. When either of these parameters are plotted versus the number of load cycles, two inflection points are apparent that define a significant change in sample behavior due to damage. The second inflection point is a reasonable definition of failure, as it is strongly correlated with the peak of the plot of phase angle versus load repetitions. Furthermore, the phase angle drops precipitously at the second inflection point. By performing controlled-strain torsional fatigue tests at three different strain levels, each great enough to induce damage, a reproducible fatigue relationship (number of load cycles as a function of stress level) is developed. The introduction of several rest periods during testing lengthened fatigue life. Successful development of this testing method is suggested as a potential specification-type test method because of its efficiency, reproducibility, and reliability.
New Synthetic Route to 6-Nitroisatin via Nitration of 3-Indolealdehyde (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Synthetic Route to 6-Nitroisatin via Nitration of 3-IndolealdehydeWayland E. Noland and Reuben D. RiekeCite this: J. Org. Chem. 1962, 27, 6, 2250–2252Publication Date (Print):June 1, 1962Publication History Published online1 May 2002Published inissue 1 June 1962https://pubs.acs.org/doi/10.1021/jo01053a529https://doi.org/10.1021/jo01053a529research-articleACS PublicationsRequest reuse permissionsArticle Views394Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts