gebhart/patrepeval huggingface dataset:
Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1α antibody, in a phase III randomized study of advanced colorectal cancer (2018)

Bermekimab is a true human monoclonal antibody that targets interleukin-1alpa (IL-1α), an inflammation-mediating alarmin. IL-1 receptor antagonist (IL-1Ra) is a natural molecule that blocks IL-1α activity by occupying the IL-1 receptor. The effect of endogenous IL-1Ra levels on the effectiveness of bermekimab is unknown. We investigated whether pre-treatment levels of circulating IL-1Ra, assessed by an enzyme-linked immunoassay, correlated with achievement of the primary outcome endpoint (effect on lean body mass and symptoms at week 8) in a Phase III study (2:1 randomization) of bermekimab versus placebo (each with best supportive care) in advanced colorectal cancer. Patients who responded to bermekimab in terms of achieving the primary endpoint had lower levels of IL-1Ra than non-responders (N = 204 patients; median = 843 vs. 1035 pg/ml, p=0.0092); no such relationship was observed in the placebo arm (N = 100 patients; 901 vs. 984 pg/ml, p = 0.55). Multivariate analysis corroborated that, in the bermekimab group, patients with lower baseline IL-1Ra levels were more likely to achieve the primary endpoint (odds ratio (OR) 1.7 (95% confidence interval (CI), 1.1 to 2.6), p = 0.017); in contrast, in the placebo arm, pre-treatment plasma IL-1Ra levels were not associated with outcome (OR 1.2 (95% CI 0.6 to 2.5), p = 0.57). The current findings demonstrate that, in a randomized phase III trial, patients with advanced colorectal cancer and lower levels of circulating IL-1Ra are more responsive to treatment with the IL-1α-targeting antibody bermekimab and these observations define a potential biomarker for anti-IL-1α therapy.
Y chromosome heterochromatin of differing lengths in two cell populations of the same individual (2005)

This study reports a direct prenatal diagnosis case of two populations of the Y chromosome in the same individual. This apparent mosaicism may be explained by a postzygotic simple deletion or unequal crossover event between sister chromatids in the DYZ region.
Effect of Molten Steel Flow on Initially Solidified Shell in Ultra Low Carbon Steel (2003)

The surface defects such as a blister and a sliver occur easily on the surface of the ultra low carbon steel sheet. The cause of these defects is bubbles or nonmetallic inclusions entrapped by the fingernail formed by the point's of solidified shell being bent or by the ruggedness part of the solidified shell in the meniscus neighborhood caused by nonuniform growth of solidified shell when molten steel is continuously cast. In this research, the influence of the molten steel flow on the nonuniformity of the solidified shell and on the formation of the fingernail structure in the ultra low carbon steel was examined. The minimum value of the thickness of initially solidified shell increases and nonuniformity decreases by the molten steel flow though nonuniformity of the solidified shell is extremely large in the ultra low carbon steel. Moreover, the size of the fingernail structure decreases as the molten steel flow velocity increases and as the molten steel temperature rises though a big fingernail structure generates in the ultra low carbon steel. In addition, the decrease in the depth of the fingernail structure and in the number of nonmetallic inclusions in continuously cast slabs by the flow which had been given to molten steel in the mold by in-mold electromagnetic stirring were confirmed.
Impact of pretransplant nutritional status in patients undergoing liver transplantation. (2011)

Preoperative BCM level was closely related to the postoperative clinical course in patients undergoing LDLT. Pretransplant nutritional status and supplementation with BCAA-enriched nutrient mixture have potent impacts on the incidence of postoperative sepsis.
Compact coder for component color television (1990)

A study of predictive coding of component TV signals for compression to transmit at rates that give good picture quality is reported. Designing predictors for minimum mean square prediction error is effective, both for luminance and chrominance signals. Predictors designed in this manner were found to be as good as or better than all other predictors tested. Quantizers designed for minimum mean square system error were primarily used in this study. A programmable testbed was built to permit quick comparisons. Predictors were compared on the testbed using a 2-b quantizer in order to have adequate system error to display visible differences. For simple intrafield coding, component signals compressed for transmission at 30 Mb/s gave about equivalent quality to an NTSC composite signal coded directly for transmission at 45 Mb/s. With 45-Mb/s transmission, component signal coding showed no detectable degradation on close inspection of real pictures. Maximum chrominance changes on test patterns yield visually detectable chrominance slope overload.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: Catalytic Asymmetric Addition of ZnPh<sub>2</sub> to Ketones: Enantioselective Formation of Quaternary Stereocenters. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cytomegalovirus: Where Have We Been and Where Are We Going? (1990)

Nearly 30 years have elapsed since Rowe and Weller and their colleagues discovered human cytomegalovirus (CMV). Because of its complex structure, long replicative cycle, low yield in vitro, and highly species-specific cell-substrate requirement, the cellular and molecular biologic analyses of human CMV have been slow, but recombinant DNA and monoclonal antibody technologies are bringing about rapid changes. Because of the long period of latency and wide range of disease presentations, epidemiologic and medical insights have also come slowly. However, the clinical events that occur during iatrogenic immunosuppression (transplantation and cancer therapy) and as a result of immunocompromise due to human immunodeficiency virus infection are currently promoting our understanding of the epidemiology of CMV disease and the definition of its clinical spectrum. Rapid diagnostic methods, antiviral drugs, and vaccines for CMV are becoming available. We may not yet understand completely the impact of this agent on the nonimmunosuppressed or aspects of its pathogenesis: e.g., the immune functions controlling recrudescence and the possibility of increased disease severity in those with no detectable immune defect. With the availability of new approaches, other issues should be clarified, such as the functions of host and virus involved in the mechanism of persistence.
<i>Staphylococcus aureus</i> UC-18: Agent of Nosocomial Infections (1964)

A new strain of Staphylococcus aureus, implicated in severe "hospital-acquired" infections, has been recognized and identified. This strain is characterized by lysis with a recently isolated bacteriophage, UC-18. Resistance to penicillin, streptomycin, and tetracycline combined with widespread prevalence in the hospital environment make S. aureus UC-18 a significant contributor to endemic staphylcoccal disease in hospitals.
Gamete imprinting: setting epigenetic patterns for the next generation (2005)

The acquisition of genomic DNA methylation patterns, including those important for development, begins in the germ line. In particular, imprinted genes are differentially marked in the developing male and female germ cells to ensure parent-of-origin-specific expression in the offspring. Abnormalities in imprints are associated with perturbations in growth, placental function, neurobehavioural processes and carcinogenesis. Based, for the most part, on data from the well-characterised mouse model, the present review will describe recent studies on the timing and mechanisms underlying the acquisition and maintenance of DNA methylation patterns in gametes and early embryos, as well as the consequences of altering these patterns.
Auslegung, Bau & Betrieb einer Flash-Pyrolyseanlage für Biomasse (2001)

No translation.
551. Synthesis of potential antibacterial agents. Part I. Some α-alkylglutaric acids and their derivatives (1950)

J. C. Roberts and B. Shaw, J. Chem. Soc., 1950, 2842 DOI: 10.1039/JR9500002842
Transcription enhances intrachromosomal homologous recombination in mammalian cells. (1992)

The influence of transcription on homologous intrachromosomal recombination between direct and inverted repeats has been examined by using Chinese hamster ovary cells. Recombination was monitored between two integrated neomycin (neo) genes, including one silent allele and a second allele regulated by the inducible mouse mammary tumor virus promoter. Transcription of mouse mammary tumor virus neo alleles was regulated with the glucocorticoid hormone dexamethasone. Alleles transcribed at high levels recombined about two- to sevenfold more frequently than identical alleles transcribed at low levels. Direct repeats recombined primarily by a gene conversion mechanism; inverted repeats produced a variety of rearranged products. These results are discussed in relation to recombinational processes that regulate gene expression, influence gene family structures, and mediate genomic instability associated with cellular transformation and tumorigenesis.
Studies on Nitrofuran Derivatives. II (1965)

In order to examine their antibacterial activity, 2- or 4-[2-(5-nitro-2-furyl) vinyl] pyridine derivatives (I), 1-[2-(5-nitro-2-furyl) vinyl] isoquinoline (II), α-(2- or 3-pyridyl)-5-nitro-2-furanacrylic acid, and their esters, amides, and nitrile derivatives (III) were synthesized. 3-[2-(5-Nitro-2-furyl) vinyl] pyridine (IV) was derived from III, and N-oxides (I′, II′, IV′) of I, II, and IV were also synthesized.
Lambertian white top-emitting organic light emitting device with carbon nanotube cathode (2012)

We demonstrate that white organic light emitting devices (OLEDs) with top carbon nanotube (CNT) electrodes show almost no microcavity effect and exhibit essentially Lambertian emission. CNT top electrodes were applied by direct lamination of multiwall CNT sheets onto white small molecule OLED stack. The devices show an external quantum efficiency of 1.5% and high color rendering index of 70. Due to elimination of the cavity effect, the devices show good color stability for different viewing angles. Thus, CNT electrodes are a viable alternative to thin semitransparent metallic films, where the strong cavity effect causes spectral shift and non-Lambertian angular dependence. Our method of the device fabrication is simple yet effective and compatible with virtually any small molecule organic semiconductor stack. It is also compatible with flexible substrates and roll-to-roll fabrication.
ChemInform Abstract: Novel Drimane Sesquiterpene Esters from Aspergillus ustus var. pseudodeflectus with Endothelin Receptor Binding Activity. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On Tuning the Near-Field Thermal Radiation Spectrum Emitted by Thin Films via Coupling of Surface Phonon-Polaritons (2009)

International audience
Topical Ocular Povidone-Iodine as an Adjunctive Preventative Practice in the Era of COVID-19 (2021)

Ophthalmologists and patients have an inherent increased risk for transmission of SARS-CoV-2. The human ocular surface expresses receptors and enzymes facilitating transmission of SARS-CoV-2. Personal protective equipment alone provides incomplete protection. Adjunctive topical ocular, nasal, and oral antisepsis with povidone iodine bolsters personal protective equipment in prevention of provider-patient transmission of SARS-CoV-2 in ophthalmology.
The Chemistry of 2<i>H</i>-3,1-Benzoxazine-2,4(1<i>H</i>)-dione (Isatoic Anhydride). 20<sup>1</sup>. Synthesis and Wittig Reactions of Dimethyl (4-Oxo-1,4-dihydro-Quinolin-2-yl)methanephosphonates (1988)

Isatoic anhydrides react with dilithiated 2-oxoalkanephosphonates to give dimethyl (4-oxo-1,4-dihydroquinolin-2-yl)methanephosphonates 5. These phosphonates undergo a Horner reaction with aldehydes to produce 2-(1-alkenyl)-4(1H)- quinolinones 10 in good yields.
[Hourly serum cortisol assay over 24hr by immunoenzymology in depression]. (1990)

Enzymoimmunoassays have been developed as alternatives to radioimmunoassays because they obviate the need for labelled compounds yet offering comparable specificity. The authors used an enzymoimmunoassay to investigate hourly serum cortisol levels over 24 hours in 6 patients (aged over 40 years) with endogenous depression (4 unipolar depressions, under antidepressor treatment and 2 bipolar depressions, without medication) and in 2 controls, aged 20 and 47 years. In agreement with literature data, a clear circadian rhythm was observed in controls and in the depressed patients, and hypercorticism was noted in one depressed patient. A trend towards phase advance in depression was seen in both the treated and untreated patients.
T Cells Through the Age(s) (2014)

T cell subset distribution throughout the human life span depends on differentiation state and tissue localization.
Practical antireflection coatings for metal-semiconductor solar cells (1976)

The metal-semiconductor solar cell is a potential candidate for converting solar energy to electrical energy for space and terrestrial application. In this paper, a method for obtaining parameters of practical antireflection (AR) coatings for the metal-semiconductor solar cells is given. This method utilizes the measured equivalent index of refraction obtained from ellipsometry, since the surface to be AR coated has a multilayer structure. Both the experimental results and theoretical calculations of optical parameters for Ta2O5 AR coatings on Au-GaAs and Au-GaAs0.78P0.22 solar cells are presented for comparison.
Skill Ontology for Mechanical Design of Learning Contents (2012)

In recent years, the effect of globalization environment, and the aging of engineers and skill workers have tremendously changed the manufacture industry, therefore, transfer of technology and skill has become a very important issue. Parallel with the advancement of the Internet, e-learning systems stress on the learning of knowledge, skill transfer is rarely mentioned. In this paper, we propose a skill ontology that consists of metadata and relationships among metadata. With the skill ontology, the document can be shared, inter-operated and thus increase the efficiency of learning process.
Improving metrology signal-to-noise on grainy overlay features (1997)

High temperature metal deposition produces large grain size and a highly visible surface morphology due to grain boundaries. When an interconnect layer photoresist pattern is aligned, grainy metal results in noisy signals from optical metrology equipment. The overlay metrology tool hardware and software configuration and target design must be optimized to obtain the best possible signal-to-noise. A powerful metric is developed herein to single out the noise component due to the overlay target image distortions. This methodology is suitable to a production environment. A variety of techniques based upon the target noise metric, including designed experiments, are employed to optimize the overlay measurements configuration.
Diagnostic Use of CFU-E Formation from Peripheral Blood in Polycythemia Vera (1983)

Peripheral blood mononuclear cells from five patients with polycythemia vera (P. vera) and three with other polycythemias were cultured in a methylcellulose system. Colony-forming unit-erythroid (CFU-E) colonies appeared after seven days in the absence of added erythropoietin (Ep) in all P. vera cultures. A pattern of growth similar to the one seen for P. vera patients occurred in the culture from a patient in whom that disease was suspected. In the cultures from two of the patients with other polycythemias, erythroid colonies did not appear even in the presence of Ep. These findings emphasize the potential value of culturing peripheral blood for CFU-E colonies in diagnosing polycythemia vera.
Fast and accurate pitch detection using pattern recognition and adaptive time-domain analysis (2005)

A method of determining pitch and voicing information from speech signals is presented. The algorithm, which employs time-domain analysis and pattern recognition techniques, is fast and yields accurate pitch and voicing estimates. A search routine is employed to find periodicity in each of four signals derived from the speech waveform and the results are combined to form a pitch estimate. The voicing decision uses linear discriminant analysis, and declares speech frames voiced or unvoiced based on a weighted sum of 13 parameters. Performance comparisons with other pitch detectors are reported.
Ranged Integers for the C Programming Language (2007)

This report describes an extension to the C programming language to introduce the notion of ranged integers, that is, integer types with a defined range of values. A variable of a ranged integer type will always have a value within the defined range as a result of initialization or assignment. Use of ranged integers would help prevent integer overflow errors and thus would result in more reliable and secure C programs. The syntax and semantics of ranged integers are presented, and some examples are given to illustrate their use.
Isotopenaustausch‐Untersuchungen an mineralischen lonenaustauschern. I. Bestimmung des Austauschvermögens (1965)

Abstract Das Austauschverhalten von Ionen in mineralischen Ionenaustauschern wird mit Hilfe des heterogenen Isotopenaustauschs untersucht. In der 1. Mitteilung werden Versuche beschrieben, das Austauschvermögen einiger Tonmineralien und Zeolithe, die in der Na‐, Sr‐bzw. Cs‐Form vorliegen, zu bestimmen. Zwischen den durch Ionenaustausch und den durch Isotopentausch erhaltenen Informationen bestehen gewisse prinzipielle Unterschiede. Die Isotopenaustauschmethode scheint besonders geeignet zu sein zur Untersuchung von Fixierungserscheinungen, die durch verminderte Beweglichkeit der Ionen bedingt sind.
Longitudinal follow-up of osseointegrated implants in patients with resected jaws. (2002)

The clinical results obtained in the present study compare favorably with those obtained by others. However, jaw reconstruction and rehabilitation should not be performed by the oral surgeon alone; oral and maxillofacial function should be restored using a team approach in close cooperation with specialists in prosthodontics and periodontics to improve the result of implant treatment.
Rhodium-Catalyzed Asymmetric [4 + 2] Cycloisomerization Reactions (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTRhodium-Catalyzed Asymmetric [4 + 2] Cycloisomerization ReactionsScott R. Gilbertson, Garrett S. Hoge, and Daniel G. GenovView Author Information Department of Chemistry, Washington University, St. Louis, Missouri 63130 Cite this: J. Org. Chem. 1998, 63, 26, 10077–10080Publication Date (Web):November 26, 1998Publication History Received15 September 1998Published online26 November 1998Published inissue 1 December 1998https://pubs.acs.org/doi/10.1021/jo981870qhttps://doi.org/10.1021/jo981870qbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1391Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Hydrocarbons,Isomerization,Ligands,Selectivity Get e-Alerts
Noninvasive mapping of the electrically stimulated mouse brain using photoacoustic microscopy (2008)

Photoacoustic imaging techniques possess high optical contrast with ultrasonic resolution while exceeding imaging depths of pure optical techniques, affording high resolution images deep within scattering biological tissues. In this work, we employ reflection-mode photoacoustic microscopy to non-invasively monitor hemodynamic contrasts and map brain activity. Changes in vascular dynamics of the mouse somatosensory cortex were evoked through electrical stimulation of the hindpaw, resulting in increased photoacoustic intensities spatially correlated with contra-lateral vasculature. Results demonstrate the ability to map brain activation with vascular resolution in three-dimensions, as well as monitor single-vessel hemodynamics with millisecond temporal resolution. Furthermore, these results implicate the feasibility of photoacoustic microscopy to probe intra-cortical single-vessel hemodynamics and pave the way for more extensive functional brain imaging studies.
Visual Search Behavior of Experienced Players while Anticipating the Success of Basketball Free Throws (2010)

The purpose of this study was to compare the visual search behaviors of experienced basketball players with those of novices as they anticipated the success of a free throw. In basketball, the accurate judgment of the result of a free throw at an early time is an important factor in both performing the next play for the players and in deciding team tactics for coaches. The subjects were twelve experienced male basketball players and twelve novice counterparts. The task was to anticipate the success of free throws by responding verbally with ‘IN’ , ‘OUT’ or ‘Uncertain’ while viewing randomized successful / unsuccessful video-based models of free throws. The video was captured from a position to the side of the shooter's shooting arm and perpendicular to the plane of the intended motion of the ball. The stimuli were temporally occluded after the ball released the shooter's hand and before the ball reached the goal. In addition, the participants' visual search behaviors were acquired by using an eye movement tracking system. The results indicated that experienced players were able to anticipate a successful free throw earlier and more accurately than could the novices. Experienced players had an effective strategy to anticipate the result of free throws that was based on not only the ball's trajectory but also the use of shooter's coordinated motions as advanced cues for predicting the success of a free throw before the release of the ball. The experienced players' viewing points were distributed on the shooter's lower body until the execution phase and then on the shooter's shooting arms before ball release. This effective visual search behavior is therefore one of the most important factors in improving accurate judgment at an early time.
Endovascular Repair of Acute AAAs under Local Anesthesia with Bifurcated Endografts: A Feasibility Study (2002)

This study demonstrates the feasibility and possible advantages of endovascular repair under local anesthesia in selected acute AAA patients. Further studies are needed to prove the advantages over open repair.