gebhart/patrepeval huggingface dataset:
Sphingosine 1-Phosphate Mobilizes Sequestered Calcium, Activates Calcium Entry, and Stimulates Deoxyribonucleic Acid Synthesis in Thyroid FRTL-5 Cells* (1997)

Sphingosine 1-phosphate (SPP) potently mobilizes sequestered calcium and is a mitogen in several cell types. In the present investigation, we have evaluated the effect of SPP on intracellular free calcium concentration ([Ca2+]i) and synthesis of DNA in thyroid FRTL-5 cells. SPP rapidly and transiently mobilized sequestered calcium and stimulated entry of extracellular calcium. The entry of calcium, but not the mobilization, was in part inhibited by pretreatment with pertussis toxin (Ptx), and by activation of protein kinase C. SPP did not stimulate the production of inositol 1,4,5-trisphosphate. SPP stimulated the incorporation of 3H-thymidine in a time- and dose-dependent manner. The effect was not inhibited by Ptx. Furthermore, SPP stimulated the activation of the proto-oncogene c-fos. SPP rapidly tyrosine-phosphorylated an approximately 66 kDa protein. This phosphorylation persisted for at least 1 h. Pretreatment of the cells with genistein abolished the SPP-evoked tyrosine phosphorylation, and attenuated the SPP-evoked increase in [Ca2+]i. Furthermore, the SPP-evoked activation of Na+-H+ exchange was inhibited by genistein. The phosphorylation was not attenuated by pretreatment of the cells with Ptx. SPP per se did not affect cellular cAMP levels but attenuated the TSH-evoked increase in cAMP. As the effect of SPP might be due to activation of phospholipase D, we tested whether phosphatidic acid (PA) mobilized calcium or stimulated the incorporation of 3H-thymidine. PA mobilized sequestered calcium but did not stimulate calcium entry. PA very modestly enhanced the incorporation of 3H-thymidine. Our results suggest, that SPP stimulates DNA synthesis and activates entry of calcium in FRTL-5 cells. The effect on calcium entry appears to be dependent, at least in part, on one or several tyrosine kinases.
Analysis of a Novel Electrically Programmable Active Fuse for Advanced CMOS SOI One-Time Programmable Memory Applications (2006)

An analysis of a novel electrically programmable element called an "active fuse" is presented. The device was manufactured in a 65nm CMOS SOI technology. The active fuse is implemented in the SOI silicon film and thus, unlike conventional polysilicon (poly) fuses, remains CMOS compatible with future gate stack materials. The authors show that an active fuse has electrical properties very similar to established electrically programmable poly fuses. Therefore, active fuses can be used as a drop-in replacement for poly fuses, with only minor changes to the layout of existing poly fuse based onetime programmable circuit blocks. Programming yield and extended bake stress reliability experiments show that the active fuse can be programmed very fast within 1mus, resulting in a very stable high resistance state. Using a statistical model, the short programming time is projected to result in near ideal programming yield of active fuse circuit macros. This novel element is therefore fully suitable for reliable one-time programmable (OTP) memory array applications that require high program yield and very good data retention properties
Femtosecond Laser-Based Microwave Signal Generation and Distribution (2016)

We review our most recent progress in microwave photonic applications of ultralow timing jitter femtosecond mode-locked fiber lasers. Sub-femtosecond timing jitter (integrated from 10 kHz to >10 MHz offset frequency) optical pulse trains can be generated from various types of mode-locked fiber lasers using dispersion engineering and intracavity filtering. To fully utilize such ultralow-jitter lasers for microwave photonic applications, we demonstrate a sub-femtosecond-resolution (-159 dBc/Hz phase noise floor) phase detection method between optical pulse trains and microwave signals using a Sagnac-fiber-loop-based device named the fiber-loop optical-microwave phase detector (FLOM-PD). Using ultralow-jitter mode-locked Er-fiber lasers and FLOM-PDs, we generate 10-GHz microwave signals with -142 dBc/Hz absolute single-sideband phase noise at 10-kHz offset frequency. When an all-fiber Michelson interferometer-based repetition-rate stabilization method is further employed, the phase noise is suppressed to -90 dBc/Hz at 10-Hz offset frequency, which results in 3-fs absolute rms timing jitter integrated from 10 Hz to 10 MHz offset frequency. Long-distance microwave phase transfer via optical fiber links is also demonstrated using the FLOM-PD as a means for stabilizing pulse time-of-flight in fiber transfer. Relative frequency instability of 6.5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-19</sup> is demonstrated for 2.856-GHz microwave signals transferred over a 2.3-km-long fiber link. We anticipate that the capability of generation, characterization, stabilization, and transfer of ultralow-noise microwave signals using ultralow-jitter femtosecond mode-locked lasers will find more applications in microwave photonics in the near future.
L'état de la discipline en relations industrielles au Canada: Un brin d'histoire et une postface (2005)

L’état de la discipline en relations industrielles au Canada : un brin d’histoire et une postface.
Modeling pulsed magnetization transfer (2007)

Modeling the effects of clinical magnetization transfer (MT) scans, which generate contrast using short, shaped radiofrequency (RF) pulses (pulsed MT), is complex and time-consuming. As a result, several studies have proposed approximate methods for a simplified analysis of the experimental data. However, potential differences in the MT parameters estimated by each method may complicate the comparison of reported results. In this study we evaluated three approximate methods currently used in quantitative MT (qMT) studies. In the first part of the investigation, an MT modeling technique that makes minimal approximations, other than the use of a two-pool tissue representation, was developed and validated. Subsequently, this technique served as a standard against which to evaluate the other, more approximate models. Each model was used to fit experimental data from samples of wild-type (WT) and shiverer mouse spinal cord, as well as simulated data generated by our minimal approximation modeling technique. The results of this study demonstrate that the approximations used in pulsed MT modeling are quite robust. In particular, it was shown that the semisolid pool fraction, M(0)(B), which is known to correlate strongly with myelin content, and the transverse relaxation time of macromolecular protons, T(2)(B), could be evaluated with reasonable accuracy regardless of the model used.
Metabolism of amino acids by rat stomach <i>in vivo</i> (1983)

Conference Article| June 01 1983 Metabolism of amino acids by rat stomach in vivo NEIL G. ANDERSON; NEIL G. ANDERSON 1Department of Biological Sciences, University of Aston, Gosta Green, Birmingham B4 7ET, U.K. Search for other works by this author on: This Site PubMed Google Scholar PETER J. HANSON PETER J. HANSON 2Department of Biological Sciences, University of Aston, Gosta Green, Birmingham B4 7ET, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1983) 11 (3): 297–298. https://doi.org/10.1042/bst0110297 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation NEIL G. ANDERSON, PETER J. HANSON; Metabolism of amino acids by rat stomach in vivo. Biochem Soc Trans 1 June 1983; 11 (3): 297–298. doi: https://doi.org/10.1042/bst0110297 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1983 Biochemical Society1983 Article PDF first page preview Close Modal You do not currently have access to this content.
Scheduled denoising autoencoders (2014)

We present a representation learning method that learns features at multiple different levels of scale. Working within the unsupervised framework of denoising autoencoders, we observe that when the input is heavily corrupted during training, the network tends to learn coarse-grained features, whereas when the input is only slightly corrupted, the network tends to learn fine-grained features. This motivates the scheduled denoising autoencoder, which starts with a high level of noise that lowers as training progresses. We find that the resulting representation yields a significant boost on a later supervised task compared to the original input, or to a standard denoising autoencoder trained at a single noise level. After supervised fine-tuning our best model achieves the lowest ever reported error on the CIFAR-10 data set among permutation-invariant methods.
THE TEXTURE OF COD MUSCLE (1974)

Abstract Data on moisture, protein content and pH (after 24 h in ice post mortem) of the flesh of cod of different sizes, captured during several fishing expeditions from Aberdeen to northern fishing grounds in spring and autumn, have been examined in relation to the texture of the cooked material. It is concluded that large fish are slightly tougher than small fish, even when the pH is the same. In addition, the pH of large fish is often lower than that of small fish, so the relative toughness of large fish is enhanced. However, the size‐pH relationship is clearly defined only in well‐fed fish at certain times of the year. At other times, when food is scarce, the post‐mortem pH of the muscle of all sizes of cod varies within wide limits, so that size no longer appears to influence the texture. Of the parameters studied, the post‐mortem pH correlated best with the texture after cooking. Since fish with a high pH usually have a high water content, there was also a correlation between texture and moisture. However, the protein content seemed to exercise a negligible influence on texture, an unexpected finding considering that protein accounts for nearly all the ‘substance’ of white fish flesh after the water has been removed.
Biological Correlates of Piracetam Clinical Effects in Psychotic Patients (1979)

The purpose of this controlled clinical trial was to demonstrate possible correlations between changes in bioenergetic metabolism and psychotropic drug administration in the treatment of functional psychosis. The study included twenty-six patients, eleven with schizophrenia, three with chronic atypical depression and twelve with drug-resistant endogenous depressions. All patients were kept on continuous psychotropic medication for at least 3 weeks before starting the trial, and piracetam was given additionally in a fixed dosage of 2400 mg daily; the same number of identical capsules was given during the pre- and post-treatment placebo periods. Psycho-pathological evaluation of the patients was by the BPRS; clinical and biochemical data were evaluated statistically by the analysis of regression. The results show that in schizophrenic patients an improvement was observed in those cases who had improved biochemically, i.e. where the ATP values had increased. In drug-resistant depressions there was a rapid and significant clinical improvement after piracetam co-administration, and this went in step with a significant rise in ATP levels.
The role of database systems in the management of multimedia information (2002)

Our research into multimedia information management and storage focuses on enabling database systems to deal with multimedia content at a high level of abstraction. We examine the database system's role in managing multimedia data. Database systems need to do more than providing a document model or binary large objects to implement multimedia database systems. We examine what the database system's role is in managing multimedia data. We then show how the role of the database system merges with the role of media servers that is an extension of traditional file servers with isochronous multimedia data delivery capabilities. The database system provides richer data management opportunities than media servers because of its increased knowledge of the stored multimedia data. This allows the database system to optimize and better manage system resources and multimedia data delivery.
HM60 cryogenic rocket engine for future European launchers (1984)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Synthesis and Characterization of Mn-Doped ZnO Nanocrystals (2004)

We report the synthesis and characterization of several sizes of Mn-doped ZnO nanocrystals, both in the free-standing and the capped particle forms. The sizes of these nanocrystals could be controlled by capping them with polyvinylpyrollidone under different synthesis conditions and were estimated by X-ray diffraction and transmission electron microscopy. The absorption properties of PVP-capped Mn-doped ZnO exhibit an interesting variation of the band gap with the concentration of Mn. Fluorescence emission, electron paramagnetic resonance, and X-ray absorption spectroscopy provide evidence for the presence of Mn in the interior as well as on the surface of the nanocrystals.
Status and Control of Syphilis in the United States (1971)

Journal Article Status and Control of Syphilis in the United States Get access William J. Brown, M.D. William J. Brown, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 124, Issue 4, October 1971, Pages 428–433, https://doi.org/10.1093/infdis/124.4.428 Published: 01 October 1971
Elimination of systematic error in subpixel accuracy centroid estimation [also Letter 34(11)3347-3348(Nov1995)] (1991)

An analysis of the properties of the centroid method for subpixel accuracy image feature location is presented. This method is free of systematic error if the maximum spatial frequency of the image incident on the image sensor is less than the sensor's sampling frequency. This can be achieved by using a lens aperture setting such that the modulation transfer function cut-off frequency due to diffraction is appropriately small. Both simulation and experimental tests of this prediction are presented for the case of the location of the center lines of the images of projected light stripes in a triangulation-based three-dimensional shape measurement system.
Vitamin-D in the Immune System: Genomic and Non-Genomic Actions (2015)

More than thirty years ago functions of vitamin D other than its beneficial effects on calcium homeostasis and bone metabolism have been identified, mainly in relation to its antiproliferative effects on cancer cells. Notably, vitamin D deficiency has been associated with a number of pathological conditions, including infections, autoimmune and allergic diseases. Vitamin D, and its metabolites, are actively involved in the regulation of innate and adaptive immune responses. Vitamin D signals through the vitamin D receptor (VDR), a specific zinc-finger nuclear receptor. The functions of vitamin D are characterized as genomic, mediated through the VDR transcriptional effects inside the cell nucleus, and non-genomic, when the VDR induces rapid signaling, situated on the cell membrane and/or cytoplasm. Emerging evidence supports the notion that vitamin D enhances immunity, providing protection towards pathogens, while, concomitantly, it exerts immunosuppressive effects by preventing the detrimental effects of prolonged inflammatory responses to the host. Still, the precise molecular mechanisms involved in vitamin D's genomic and non-genomic actions remain incompletely defined. Moreover, it is unclear whether vitamin D actions require the synergistic activation of other mediators, such as nuclear membrane receptors. Understanding the biology of vitamin D and the molecular pathways utilized will pave the way for the design of more effective therapeutic strategies. In this review, we present the recent genomic and non-genomic effects of vitamin D from an immunological perspective with a focus on immune-mediated diseases.
N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism (2019)

Parkinson's disease etiology involves amyloid formation by α-synuclein (αSyn). <i>In vivo</i>, αSyn is constitutively acetylated at the α-amino N-terminus. Here, we find N-terminally acetylated αSyn (Ac-αSyn) aggregates more slowly than non-acetylated αSyn (NH<sub>3</sub>-αSyn) with significantly reduced sensitivity to thioflavin T (ThT). Fibril differences were characterized by transmission electron microscopy, circular dichroism spectroscopy, and limited proteolysis. Interestingly, the low-ThT Ac-αSyn fibrils seed both acetylated and non-acetylated αSyn and faithfully propagate the low-ThT character through several generations, indicating a stable fibril polymorph. In contrast, the high-ThT NH<sub>3</sub>-αSyn seeds lose fidelity over subsequent generations. Despite it being outside of the amyloid core, the chemical nature of the N-terminus modulates αSyn aggregation and fibril polymorphism.
Synergistic Effects of Plant Extracts and Antibiotics on Staphylococcus aureus Strains Isolated from Clinical Specimens (2009)

This study has been done to evaluate the interaction between water extracts of Psidium guajava, Rosmarinus officinalis, Salvia fruticosa, Majorana syriaca, Ocimum basilucum, Syzygium aromaticum, Laurus nobilis and Rosa damascena alone and then synergy testing of these extracts with known antimicrobial agents of different mechanisms (protein synthesis inhibition: oxytetracycline HCl and gentamicin sulfate; cell wall synthesis inhibition: penicillin G and cephalexin; folic acid synthesis inhibition: Sulfadimethoxine as sodium; and nucleic acid synthesis inhibition: enrofloxacin) using both well-diffusion and microdilution method. This study was conducted against five S. aureus isolates; one is Methicillin-resistant Staphylococcus aureus (MRSA) and 4 Methicillin-sensitive Staphylococcus aureus (MSSA). The results of the conducted experiments using well-diffusion method demonstrate that these plants showed in vitro interactions between antimicrobial agents and plant extracts were additive against the five strains of S. aureus, while using microdilution method showed synergistic effects between combination of antibiotics and plant extracts with significant reduction in the MICs of the test antibiotics against these strains of S. aureus. This change in MIC was noticed in all plant extracts against test antibiotics including these plants showed weak antibacterial activity by well diffusion method. Also our results showed that synergism effect between antimicrobial agent and plant extract was occurred in both sensitive and resistant strains but the magnitude of minimum fold inhibition in resistant strains especially MRSA strain was higher than the sensitive strains.
<i>In vitro</i>anti-bacterial and anti-adherence effects of natural polyphenolic compounds on oral bacteria (2008)

This is, to our knowledge, the first and the most complete report on the properties of wine and pine bark extracts that could be used for oral disease prevention purpose.
Use of erythropoietin to increase the volume of autologous blood donated by orthopedic patients (1993)

For patients who donate blood for autologous use and undergo major orthopedic surgery, low basal hematocrit (Hct) is the major cause of allogeneic blood exposure. To determine whether recombinant human erythropoietin (rHuEPO) could increase autologous blood procurement and reduce allogeneic blood exposure, a prospective randomized study was conducted in 50 women undergoing total hip replacement who had basal Hct < 40 percent (0.40). Patients were randomly placed in three groups: those receiving placebo, those receiving 300 U of rHuEPO per kg, and those receiving 600 U of rHuEPO per kg every 3 to 4 days for 21 days. Oral iron (125-270 mg/day) was given; in the last 24 patients, 100 mg of iron saccharate was administered intravenously at each donation. At each visit, 350 mL of blood was collected if Hct was > or = 34 percent (0.34). Patients receiving rHuEPO donated a greater amount of blood for autologous use than did patients in the placebo group (4.5 +/- 1.1 vs. 2.8 +/- 0.6 units; p < 0.05) and received a significantly lower amount of allogeneic blood (1.2 +/- 1.4 vs. 0.4 +/- 0.8 units; p < 0.05). No difference between the effects of the two doses of rHuEPO was observed. Iron support was a critical factor in the efficacy of treatment. No untoward effects were observed. The rHuEPO emerged as a safe and effective treatment, with adequate iron support, by which to increase preoperative deposit of autologous blood and to reduce exposure to allogeneic blood for patients with low basal Hct.
Calculation of bandwidth from index profiles of optical fibers 1: Theory (1979)

This paper describes a method for calculating the impulse response and bandwidth of multimode optical fibers from measured refractive-index profiles obtained either from the fiber itself or from its preform. The computational method is based on the WKB solution of the guided-mode problem. First, the pulse delay time of each mode is calculated. The different arrival times of impulses carried by the modes are then used to construct the shape of the impulse response curve whose Fourier transform may be used to predict the signal bandwidth of the multimode fiber. By omitting mode groups or weighting the power distribution among the modes, the influence of certain mode groups on pulse distortion can be studied separately. Dispersion of the host material and of one dopant can be taken into account. The method has been used to study the effects of deviations from the desired perfect index profile and the influence of a central dip. The practical value of the computer program is its ability to predict fiber performance from index measurements made on preforms even before the fiber is drawn.
Heuristics for service technician routing and scheduling problems (2009)

Die Arbeit befasst sich mit dem service technician routing and scheduling Problem. Das Problem entsteht dadurch, dass eine fixe Belegschaft von unterschiedlich ausgebildeten Technikern eine Menge von Aufträgen bearbeiten muss die unterschiedliche Fachkenntnisse erfordern. Erschwerend kommt hinzu, dass die Aufträge örtlich unterschiedlich gelegen sind und nur in bestimmten Zeitfenstern besucht werden können. Darüber hinaus kommt es vor, dass manche Aufträge zu hohe Anforderungen an einzelne Techniker stellen. Dies erfordert die Zusammengruppierung von mehreren Technikern um mit den vereinten Kenntnissen den nachgefragten Anforderungen gerecht zu werden. Grundsätzlich kann dieses Problem als eine Erweiterung des vehicle routing Problems (VRP) verstanden werden, wobei die Fahrzeuge durch die Techniker oder Teams ersetzt werden und die Kunden durch die Aufträge mit den unterschiedlichen Anforderungen. Die Herausforderung besteht nun darin, Routen zu generieren die möglichst viele Aufträge einschließen, wobei den nachgefragten Fähigkeiten und den Zeitfenstern entsprochen wird. Um das Problem zu lösen wird die sogenannte adaptive large neighborhood search Heuristik (ALNS) angewendet