gebhart/patrepeval huggingface dataset:
Rod-Shaped Monocytes Patrol the Brain Vasculature and Give Rise to Perivascular Macrophages under the Influence of Proinflammatory Cytokines and Angiopoietin-2 (2008)

The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68(+)GR1(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endothelium, these monocytes start to crawl, adopt a rod-shaped morphology when passing through capillaries, and can manifest the ability to proliferate and form a long cytoplasmic protuberance. They are attracted in greater numbers during endotoxemia by a combination of vasoregulatory molecules, including TNF (tumor necrosis factor), interleukin-1beta, and angiopoietin-2. After a period of several hours, some of them cross the endothelium to expand the population of perivascular macrophages. Depletion of adherent monocytes and perivascular macrophages can be achieved by injection of anti-angiopoietin-2 peptide-Fc fusion protein. This study extends our understanding of the behavior of monocytes at the blood-brain interface and provides a way to block their infiltration into the nervous tissue under inflammatory conditions.
Generation of Active Ruthenium Catalysts for Hydroarylation of C–C Multiple Bonds from Isolated Ru(IV)=O Species Supported on CeO2 (2018)

Abstract This paper reports that the treatment of Ru/CeO2 with PPh3 and HCHO in 2-methoxyalcohol was an efficient way to generate the catalytically active Ru species for hydroarylation of C-C multiple bonds. A variety of alkenes was applicable toward the title reactions. The solid Ru/CeO2 could be recycled for several times.
Development of a transposon-based approach for identifying novel transgene insertion sites within the replicating adenovirus (2005)

Therapeutic gene delivery from an oncolytic adenovirus (Ad) is one approach to enhancing the potency of Ad-based virotherapies for cancer. To identify therapeutic transgene insertion sites compatible with the replicating virus, a methodology that broadly scans the viral genome is needed. To address this we modified a transposon (Tn7)-based in vitro transposition system to take advantage of its nonprejudiced scanning ability to identify insertion sites compatible with viral replication. Using this system with a plasmid containing an E3-deleted Ad5, we identified several unique sites for promoter-based expression cassette insertions within the Ad genome. The transposon-based expression cassette is bounded by PmeI restriction endonuclease sites unique to the transposon, making expression cassette substitutions easy to perform. Additional expression cassettes containing different promoters and reporter genes were substituted into two of the newly identified transgene insertion sites. The results suggest that the ease and orientation of expression cassette substitution depend on both the insertion site location and the promoter and gene of the replacement expression cassette. These studies establish the transposon-based system as an efficient approach to scanning the Ad genome and identifying insertion sites compatible with viral replication and represents a powerful tool for the development of armed therapeutic viruses for cancer.
Analysis of branch prediction via data compression (1996)

Branch prediction is an important mechanism in modern microprocessor design. The focus of research in this area has been on designing new branch prediction schemes. In contrast, very few studies address the theoretical basis behind these prediction schemes. Knowing this theoretical basis helps us to evaluate how good a prediction scheme is and how much we can expect to improve its accuracy.In this paper, we apply techniques from data compression to establish a theoretical basis for branch prediction, and to illustrate alternatives for further improvement. To establish a theoretical basis, we first introduce a conceptual model to characterize each component in a branch prediction process. Then we show that current "two-level" or correlation based predictors are, in fact, simplifications of an optimal predictor in data compression, Prediction by Partial Matching (PPM).If the information provided to the predictor remains the same, it is unlikely that significant improvements can be expected (asymptotically) from two-level predictors, since PPM is optimal. However, there are a rich set of predictors available from data compression, several of which can still yield some improvement in cases where resources are limited. To illustrate this, we conduct trace-driven simulation running the Instruction Benchmark Suite and the SPEC CINT95 benchmarks. The results show that PPM can outperform a two-level predictor for modest sized branch target buffers.
Selective Intrabronchial Air Insufflation for Acute Lobar Collapse in the Surgical Intensive Care Unit. (2011)

OVERVIEW: The horseshoe kidney is more prone to blunt abdominal trauma because of its low position and the presence of the isthmus across the midline. This is a rare case of complete transection of a horseshoe kidney at the isthmus due to blunt abdominal trauma with two sites of active extravasation on initial CT imaging. This extravasation was successfully treated by embolization with coils. Superselective embolization may be used for effective, minimally invasive control of active extravasation due to blunt renal trauma, even in kidneys with congenital malformations such as the horseshoe kidney.
Is a new needs assessment tool necessary for head and neck cancer patients? (2004)

5571 Background: Instruments assessing supportive care needs of cancer patients are limited; and of those available, such as the Supportive Care Needs Survey (SCNS), the instruments are not specifically developed for head and neck cancer patients. A comprehensive needs assessment of cancer patients is necessary to determine appropriate allocation of supportive care resources and to optimize delivery of quality care. We conducted an exploratory study using qualitative methods, as phase two of a three phase project, to define and measure supportive care needs in head and neck cancer patients. Methods: A purposive sample of 9 multidisciplinary health care providers and 20 ambulatory patients with head and neck cancer completed a semi-structured interview exploring supportive care needs. We performed content analysis of interview transcripts using pre-specified categories of need from the literature (psychological, physical, social, informational, health system, and spiritual needs). Results: Mean age of participants was 60 yrs (32–86). Physical needs were the most frequently reported with the majority of responses related to symptom control. Psychological needs ranked second in frequency with most responses related to coping, distress, and body image. Social and spiritual needs were similar in frequency but higher than health system and informational needs. Conclusions: The needs items generated by this qualitative study will be compared to an existing valid and reliable needs assessment instrument (SCNS) to determine if there are any items relevant to head and neck cancer patients not captured by the SCNS. The outcome of these results may indicate the need for a head and neck specific needs assessment scale to be developed. No significant financial relationships to disclose.
Polymerization of Tetrafluoroethylene in a Hybrid Carbon Dioxide/Aqueous Medium (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymerization of Tetrafluoroethylene in a Hybrid Carbon Dioxide/Aqueous MediumT. J. Romack, B. E. Kipp, and J. M. DeSimoneCite this: Macromolecules 1995, 28, 24, 8432–8434Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ma00128a066https://doi.org/10.1021/ma00128a066research-articleACS PublicationsRequest reuse permissionsArticle Views403Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Application of conducting polymers to electroanalysis (1994)

Conducting polymers can be used as sensitive layers in chemical microsensors leading to new applications of theses devices. They offer the potential for developing material properties that are critical to the sensor sensitivity, selectivity and fabrication. The advantages and limitations of the use of thin polymer layers in electrochemical sensors are discussed.
An Approximate Skew Incidence Diffraction Coefficient for an Impedance Wedge (1992)

ABSTRACT An approximate diffraction coefficient is presented for an impedence wedge at skew incidence. This is based on suitable modifications of the available skew incidence solutions for an impedance half plane. The derived coefficients reduce to those for an impedance wedge at normal incidence, a perfectly conducting wedge at skew incidence as well as the impedance half Plane at skew incidence. An additional crucial requirement that the total field remairs continuous at the reflection and. shadow boundary is also imposed, using the derived approximate diffraction coefficient, a first order solution is obtained for the scattering by a polygonal impedance cylinder at skew mcidence. ThiS.is then compared with numerical data to validate the accuracy of the presented dyadic coefficient.
Extraction of second harmonic from an InP based planar Gunn diode using diamond resonator for milli-metric wave frequencies (2015)

Planar Indium Gallium Arsenide (In0.57Ga0.47As) Gunn diode was fabricated on a semi-insulating indium phosphide substrate with on chip matching circuit to enable the extraction of second harmonic in millimeter and terahertz frequencies. The In0.57Ga0.47As planar Gunn diodes were designed with an active length of 4 lm, channel width of 120 lm and integrated with a novel diamond resonator to suppress the fundamental and extract the second harmonic. The experimental results gave good fundamental suppression and extraction of second harmonic (121.68 GHz) with an RF output power of 14.1 dBm.
The PROVe Study: US Real-World Experience with Chlormethine/Mechlorethamine Gel in Combination with Other Therapies for Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma (2021)

This real-world study confirmed that chlormethine gel is an important therapeutic option for patients with mycosis fungoides and contributes to reducing the severity of skin lesions and improving health-related quality of life.
Prognostic significance of histopathologic response to chemotherapy in nonmetastatic Ewing's sarcoma of the extremities. (1993)

This new histopathologic analysis technique for the evaluation of neoadjuvant chemotherapy effectiveness (which does not rely on tumor volume for its assessment) is a valuable prognostic indicator for patients with Ewing's sarcoma treated with surgery. Based on this preliminary report, cases of grade I or II chemotherapeutic tumor response should be considered clinical failures and a different, more aggressive postoperative chemotherapy regimen should be considered.
International SAMPE Technical Conference, 21st, Atlantic City, NJ, Sept. 25-28, 1989, Proceedings (1989)

The present conference discusses topics in prospective advanced materials market trends, advanced fabrication techniques, adhesives technologies, state-of-the-art reinforcements and fillers for composites, damage and failure mechanisms is novel materials, DoD and NASA marketing opportunities for aerospace matrials, testing and quality control methods, advanced materials repair technologies, and toughened thermosetting resins. Also discussed are materials processing-related health and safety issues, design methods for high-performance composites, high-temperature thermoplastic polymers, fiber and fabric technologies for composite reinforcements, metal-matrix composites, industrial uses of composites, composites for ballistic applications, and high temperature-resistant thermosetting polymers.
Proteomics: A Tool for Understanding Lactic Acid Bacteria Adaptation to Stressful Environments (2010)

This chapter contains sections titled: Introduction “Omics”: A New Biology Approach Proteomics State of the Art of Proteomics in LAB Concluding Remarks and Future Directions References
Soil Fungicides for Controlling Chytridiaceous Mycoparasites of <i>Gigaspora margarita</i> and <i>Glomus fasciculatum</i> (1983)

The percentage of azygospores of Gigaspora margarita with zoosporangia of chytridiaceous fungi (CF) was reduced significantly after agitating them in fenaminosulf before incubation in soil. Fenaminosulf did not affect zoosporangia development on chlamydospores of Glomus fasciculatum. Metalaxyl and ethazol were not effective against CF on spores of either mycorrhizal fungus. Azygospores of G. margarita were treated with fenaminosulf and used as the inoculum for pot cultures. After 19 weeks, the percentage of azygospores containing CF was reduced significantly by this treatment, whereas root colonization and sporulation by the mycorrhizal fungus were unaffected. Pot cultures of G. margarita, either drenched with fenaminosulf or not, did not differ in the percentage of azygospores containing CF. However, root colonization and sporulation by the mycorrhizal fungus was temporarily delayed when pots were drenched with fenaminosulf.
ChemInform Abstract: Effect of Acid Strength of Co‐Precipitated Chromia/Alumina Catalyst on the Conversion and Selectivity in the Fluorination of 2‐Chloro‐1,1,1‐trifluoroethane to 1,1,1,2‐Tetrafluoroethane. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The flight control system for the Daedalus human powered aircraft (1989)

Because the final flight of the Daedalus human powered aircraft was expected to take up to six hours, an autopilot was designed to reduce the pilot's workload. The functions of the system were to hold a constant airspeed, to maintain a wings level attitude, and to track a constant heading. Though the flight control system was never integrated into the aircraft, the individual components (sensors, actuators, and compensator) were tested. The sensors included an airspeed sensor, electrostatic attitude sensors, solid state rate gyros, and a flux-gate compass. The airspeed sensor and the compass worked reasonably well; however, the rate gyros suffered from hysteresis effects and the electrostatic sensors tended to saturate. These problems prevented the control loops from being closed. An actuator system for the rudder and elevator was tested, and did allow the attitude of the aircraft to be precisely controlled. During flight tests in the winter of 1987-88, it was discovered that flexibility of the tailboom caused a significant lag between the deflection of the aerodynamic control surfaces and the subsequent moments acting on the fuselage. The performance of the autopilot compensator was analytically evaluated in light of these dynamics. In this analysis, degradations of the autopilot's performance were observed when the flexibility effects were included; however, adequate performance was achieved by proper augmentation of the feedback compensation. The experience gained from these tests on the autopilot components should prove valuable to the designers of autopilots for future human powered aircraft and for the proposed high altitude, solar powered aircraft similar in configuration to the Daedalus aircraft.
Study on hybrid storage method of AMI mass data (2014)

Currently, the data size of Advanced Metering Infrastructure (AMI) system is leaping rapidly. The traditional data storage solution in most AMI systems utilize Relational Data Base Management System (RDBMS) However, current RDBMS can hardly meet the requirements of high-speed storage, computation and analysis when faced with mass data, which places a huge limit on potential applications. This paper proposes a method that divides AMI system data into measurement data and management data according to their respective characteristics. The method utilizes a hybrid of Hadoop Distributed File System (HDFS) and RDBMS to sort and store data as well as to gain unified data access. A detailed classification, storage and extraction process and the system design are presented in the paper. Finally, a comparative test of typical AMI business scenario is carried out. The results show that this method has a significant advantage in efficiency and good scalability for processing AMI mass data.
Type II Minimal‐Invasive Extracorporeal Circuit for Aortic Valve Replacement: A Randomized Controlled Trial (2018)

Extracorporeal circulation triggers systemic inflammatory response and coagulation disorders which may lead to unfavorable clinical outcome. A type II minimally-invasive extracorporeal circuit (MiECC) is a closed system with markedly reduced artificial surface as compared to conventional extracorporeal circuits (CECC). The aim of this study was to investigate and compare inflammatory responses, complement activation and selected clinical end-points in isolated surgical aortic valve replacement (SAVR) performed with a type II MiECC circuit or a CECC. Fifty patients were prospectively randomized to MiECC or CECC perfusion regimen. Complement activation (sC5b-9), inflammation (IL-6, TNF-α, sCD40-ligand) and activation of the coagulation system (D-dimer, TAT-complex) were determined before operation, at 2 hours and 24 hours after surgery. Clinical end-points included perfusion time, transfusion of allogeneic blood products, postoperative bleeding, sepsis, new onset of atrial fibrillation, stroke and in-hospital mortality. Patient characteristics and baseline plasma markers were similar in both groups. Levels for sC5b-9, TNF-α, sCD40 ligand, TAT-complex and D-dimers were not significantly different between MiECC and CECC at 2 hours and 24 hours after surgery. The IL-6 plasma concentration was lower in the CECC group at 24 hours (P = 0.026, vs. MiECC). Comparisons of the baseline level to values at 2 hours and 24 hours, adjusted for the type of oxygenator and hemoglobin, showed a significantly lower sC5b-9 in MiECC at 2 hours (P = 0.013), but no difference at 24 hours (P=0.990). Compared with CECC, MiECC patients had a shorter perfusion time (P = 0.037) and less transfusion requirements (P = 0.04). In this selected cohort of SAVR patients, the type II MiECC was not inferior to CECC in terms of inflammatory response and complement activation. Thus, MiECC might be an alternative perfusion strategy to conventional.
Characterization of a temperature-sensitive Escherichia coli mutant and revertants with altered seryl-tRNA synthetase activity (1997)

A mutation in the structural gene coding for seryl-tRNA synthetase in temperature-sensitive Escherichia coli K28 has been reported to alter the level of enzyme expression at high temperature (R. J. Hill and W. Konigsberg, J. Bacteriol. 141:1163-1169, 1980). We identified this mutation as a C-->T transition in the first base of codon 386, resulting in a replacement of histidine by tyrosine. The steady-state levels of serS mRNA in K28 and in the wild-type strains are very similar. Pulse-chase labeling experiments show a difference in protein stability, but not one important enough to account for the temperature sensitivity of K28. The main reason for the temperature sensitivity of K28 appears to be the low level of specific activity of the mutant synthetase at nonpermissive temperature, not a decreased expression level. Spontaneous temperature-resistant revertants were selected which were found to have about a fivefold-higher level of SerRS than the K28 strain. We identified the mutation responsible for the reversion as being upstream from the -10 sequence in the promoter region. The steady-state levels of serS mRNA in the revertants are significantly higher than that in the parental strain.
IDENTIFICATION OF MEDICINAL PLANTS OF HAMEDAN PROVINCE (2007)

Collection and Determination of Medicinal Plants in Hamedan province have been carried out since 1995 for five years in the center of national resources and animal affairs of Hamedan province. Medicinal plants of different regions were collected by using field study and information of experienced people traditional medicine. Some informations including scientific name, family name, Persian name, local name, botany specifications, distribution area in the province, herbarium number,  habitat, the height from sea level,  utilized organ, manner of usage, liables to use in traditional and  local medicine, and  chemical composition in species, etc. were recorded for each medicinal plant.  By the end of project, totally 6000 herbaceous species were collected from different regions of the province, which 315 medicinal plants were identified and related to 71 families and 209 genus. These numbers included species which were self-grown (wild) in natural resource boards of province and 159 species have traditional usage in the province and 156 species are out of traditional and indigenous use but they are called medicinal plants in drug resources.
Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables (2010)

Consumption of cruciferous vegetables has been associated with a reduced risk in the development of various types of cancer. This has been attributed to the bioactive hydrolysis products that are derived from these vegetables, namely isothiocyanates. Erucin is one such product derived from rocket salads, which is structurally related to sulforaphane, a well-studied broccoli-derived isothiocyanate. In this review, we present current knowledge on mechanisms of action of erucin in chemoprevention obtained from cell and animal models and relate it to other isothiocyanates. These mechanisms include modulation of phase I, II and III detoxification, regulation of cell growth by induction of apoptosis and cell cycle arrest, induction of ROS-mechanisms and regulation androgen receptor pathways.