gebhart/patrepeval huggingface dataset:
Epigenetics and chronic lymphocytic leukemia (2006)

The DNA methylation level in patients with chronic lymphocytic leukemia is generally lower than healthy individuals. Although DNA methylation is globally decreased, regional hypermethylation of gene promoters leads to gene silencing. Many of these genes have tumor suppressor phenotypes. Unlike mutations or deletions, hypermethylation is potentially reversible after inhibition with DNA methylation modulators. Myelodysplastic syndrome has been a model disease in which treatment of patients results in demethylation of specific genes. The story in patients with chronic lymphocytic leukemia is slowly unraveling as epigenetic modifications likely also play an important role. Ongoing clinical trials correlating clinical response to gene expression after treatment with DNA methylation inhibitors will ultimately allow us to better risk stratify and predict the subgroup of patients who will benefit from treatment with this class of drugs.
Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches (2018)

Neuropsychiatric disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and depression, have seriously inconvenienced the lives of patients. Growing evidence indicates that these diseases are closely related to the monoamine oxidase (MAO) enzyme, making it an attractive target for the exploitation of potent MAO inhibitors (MAOIs) with high selectivity and low side effects. Although various MAOIs have been discovered, the discovery of an ideal MAOI is not an easy task. In this review, we discuss the currently available rational design strategies for obtaining ideal MAOIs, including ligand-based and receptor-based design strategies, and these strategies were further illustrated with the aid of specific examples from the recent literature. To better understanding the biological activity of MAO, we also highlight the binding modes of typical inhibitors against MAO. Besides, advanced strategies for finding upcoming potent MAOIs were prospected.
Distributed e-voting using the Smart Card Web Server (2012)

Voting in elections is the basis of democracy, but citizens may not be able or willing to go to polling stations to vote on election days. Remote e-voting via the Internet provides the convenience of voting on the voter's own computer or mobile device, but Internet voting systems are vulnerable to many common attacks, affecting the integrity of an election. Distributing the processing of votes over many web servers installed in tamper-resistant, secure environments can improve security: this is possible by using the Smart Card Web Server (SCWS) on a mobile phone Subscriber Identity Module (SIM). This paper proposes a generic model for a voting application installed in the SIM/SCWS, which uses standardised Mobile Network Operator (MNO) management procedures to communicate (via HTTPs) with a voting authority to vote. The generic SCWS voting model is then used with the e-voting system Prêt à Voter. A preliminary security analysis of the proposal is carried out, and further research areas are identified. As the SCWS voting application is used in a distributed processing architecture, e-voting security is enhanced because to compromise an election, an attacker must target many individual mobile devices rather than a centralised web server.
Inheritance of Foliage Striping in Pearl Millet (1969)

The inheritance of foliage striping, viz., yellow striping in purple foliage, yellow striping in green foliage and white and yellow striping in green foliage has been reported. The striping of foliage with yellow or white and yellow stripes was recessive to non-striped foliage. Yellow striping in purple as well as green foliage was determined by three complementary recessive genes while the development of white and yellow stripes in green foliage was governed by different sets of genes with duplicate, complementary and inhibitory type of gene interactions. The yellow colour of stripes of the two genetic stocks PYS-7 and GYS-8 was controlled by the same set of genes; both these stocks were differentiated from GWS-14 by one of the three loci determining yellow colour of stripes.
[The limitation of lipid hyperperoxidation and the prevention of stressor damages to the heart by glycine derivatives]. (1997)

It is shown that glycine derivatives decrease considerably activation of lipid peroxidation in stress, reduce the duration of the alarm stage of the stress reaction, and limit the stress damage to the heart. The idea of the organism's glycinergic stress limiting system is suggested.
집합교재의 체계적 분석연구 (1965)

One of the prerequisites for the improvement of the teaching of mathematics in our country is an improved curriculum---one which takes account of the increasing use of mathematics in science and technology and in other areas of knowledge and at the same time one which reflects recent advances in mathematics itself. In the new curriculum of mathematics, we have found the problems to teach the concept of sets at secondary level. The idea of a set is the most fundamental one in mathematics. So, this thesis contains the studies of the systematic analysis of sets in dealing with the traditional textbook. The scope of the work is limited to the fundamental ideas, and so it merely touches on the topics of the Concepts, Operations, Cardinal Numbers, Application of Logic, One-to-one Correspondence, Probability and so on. It provides only the essentials, definitions, proofs and some example which are already known and understood in their traditional context. It also presents at the appropriate stages the concepts required (illustrated by examples) in a much clearer fashion than classical teaching does. To compete a study of the sets covered in the textbook of each year, greater detail is needed at the appropriate level.
Invasive multidrug-resistant non-typhoidal Salmonella infections in Africa: zoonotic or anthroponotic transmission? (2006)

In Africa, multidrug-resistant non-typhoidal salmonellae (NTS) are one of the leading causes of morbidity and high mortality in children under 5 years of age, second in importance only to pneumococcal disease. The authors studied NTS isolates from paediatric admissions at two hospitals in Nairobi, Kenya, and followed the index cases to their homes, where rectal swabs and stools from parents and siblings, and from animals in close contact, were obtained. The majority of NTS obtained from cases were Salmonella enterica serotype Typhimurium (106 out of 193; 54.9%) and Salmonella enterica serotype Enteritidis (64; 33.2%), a significant proportion (34.2%) of which were multiply resistant to three or more antibiotics, including ampicillin, tetracycline, cotrimoxazole and chloramphenicol. Only 23.4% of NTS were fully susceptible to all 10 antibiotics tested. Of the 32 NTS obtained from contacts (nine adults and 23 children) at the homes of index cases, 21 (65.6%) isolates were similar by antibiotic-susceptibility profiles and plasmid content, and their XbaI- and SpeI-digested chromosomal DNA patterns were indistinguishable from those of the corresponding index cases. Only three out of 180 (1.7%) samples from environmental sources, including animals, soil, sewers and food, contained NTS matching those from corresponding index cases. The carriage of NTS in an asymptomatic population was represented by 6.9% of human contacts from 27 out of 127 homes sampled. This population of carriers may represent an important reservoir of NTS that would play a significant role in the epidemiology of community-acquired NTS bacteraemia in children.
New Fluorene Derivatives for Blue Electroluminescent Devices:  Influence of Substituents on Thermal Properties, Photoluminescence, and Electroluminescence (2008)

A new series of fluorene derivatives with different substituents at the C-2,7- and C-9 positions has been synthesized and characterized with respect to their luminescence and thermal properties. It was found that substitutions at the C-2,7 positions significantly affected the thermal properties and optical properties, whereas substitutions at the C-9 position mainly affected the thermal properties of the fluorene derivatives. Organic light-emitting diodes (OLEDs) with a structure of indium tin oxide (ITO)/copper phthalocyanine (CuPc) (15 nm)/4,4‘-bis[N-(1-naphthyl)-N-phenylamino]biphenyl (NPB) (50 nm)/fluorene derivative (30 nm)/tris(8-quinolinolato)aluminum (Alq3) (50 nm)/Mg/Ag (200 nm) were fabricated. OLEDs based on the naphthyl-substituted fluorenes gave saturated blue emission centered at 452 nm, while those based on anthryl-substituted fluorenes showed a blue−green emission with a wider spectrum. OLEDs based on 2,7-dipyrenyl-9‘9-dimethylfluorene (DPF) exhibited blue emission with a maximum efficiency of 4.8 cd/A and CIE coordinates of x = 0.17 and y = 0.24. A similar DPF-based device with an additional hole block layer exhibited better blue emission with a maximum efficiency of 5.2 cd/A and CIE coordinates of x = 0.15 and y = 0.21, which are among the best values ever reported for blue OLEDs without a dopant based on fluorescence molecules. The results show that fluorenes with suitable substitutents can act as blue-emitting materials with a high thermal stability and high electroluminescence efficiency.
Combining both microcode and hardwired control in RISC (1987)

article Free Access Share on Combining both microcode and hardwired control in RISC Authors: Amitava Bandyopadhyay Clemoson Univ., Clemson, SC Clemoson Univ., Clemson, SCView Profile , Yuan F. Zheng Clemson Univ., Clemson, SC Clemson Univ., Clemson, SCView Profile Authors Info & Claims ACM SIGARCH Computer Architecture NewsVolume 15Issue 4September 1, 1987 pp 11–15https://doi.org/10.1145/36974.36976Online:01 September 1987Publication History 0citation157DownloadsMetricsTotal Citations0Total Downloads157Last 12 Months11Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Real-time acquisition and representation of 3D environmental data (2012)

We develop a mobile system to acquire and represent 3D environmental data for modeling indoor spaces. The system is composed of a laser range finder (LRF) and an omni-directional camera. Multiple 3D point clouds from different viewpoints are acquired as the geometric information by scanning a scene with the LRF, while an omni-directional texture image is acquired with the omni-directional camera. We merge those multiple 3D point clouds into a single point cloud. We then combine the point cloud and the texture image into a complete 3D mesh model in three steps. First, we downsample the point cloud based on a voxel grid and estimate the normal vector of each point. Second, using the normal vectors, we reconstruct a 3D mesh based on the Poisson surface reconstruction. Third, to assign texture information to the mesh surface, we estimate the matching region in the omni-directional image that corresponds to each face of the mesh. Simulation results demonstrate that the proposed system can reconstruct indoor spaces effectively.
Suitability of various excipients as carrier and coating materials for liquisolid compacts (2011)

If Neusilin(®) is used as carrier and coating material instead of Avicel(®) (carrier material) and Aerosil(®) (coating material), the TA adsorption capacity is increased by a factor of 7.
Eudragit® L100/N-Trimethylchitosan Chloride Microspheres for Oral Insulin Delivery (2013)

Effective oral delivery of protein and peptide drugs remains an active topic in scientific research. In this study, matrix type microspheres were prepared with Eudragit® L100 containing N-trimethylchitosan chloride to improve the permeation of insulin across the intestinal epithelium via the paracellular pathway. Insulin loaded microspheres were initially formulated in accordance with a factorial design (23) and manufactured by means of a single water-in-oil emulsification/evaporation method. Based on external and internal morphology two microsphere formulations were selected from the initial formulations for further investigation in terms of particle size, dissolution behaviour and in vitro insulin transport across excised rat intestinal tissue. The initial eight microsphere formulations exhibited drug loading capacities ranging from 27.9-52.4% with different shapes and internal structures. The two selected microsphere formulations had average particle sizes of 157.3 ± 31.74 µm and 135.7 ± 41.05 µm, respectively, and mean dissolution time values for insulin release of 34.47 and 42.63 min, respectively. In vitro transport of insulin across excised rat intestinal tissue from the two selected microsphere formulations was 10.67-fold and 9.68-fold higher than the control group (insulin alone). The microsphere delivery system prepared from Eudragit® L100 containing N-trimethylchitosan chloride is therefore a promising candidate for effective oral insulin delivery.
Face detection and eye localization by neural network based color segmentation (2002)

This paper presents a neural network based scheme for human face detection and eye localization in color images under an unconstrained scene. A self-growing probabilistic decision-based neural network (SPDNN) is used to learn the conditional distribution for each color classes. Pixels of a color image are first classified into facial or non-facial regions, then pixels in the facial region are followed by eye region segmentation. The class of each pixel is determined by using the conditional distribution of the chrominance components of pixels belonging to each class. The paper demonstrates a successful application of SPDNN to face detection and eye localization on a database of 755 images from 151 persons. Regarding the performance, experimental results are elaborated. As to the processing speed, the face detection and eye localization processes consume approximately 560 ms on a Pentium-II personal computer.
Resistive bridge fault modeling, simulation and test generation (2003)

In this work/sup 1/ we develop models of resistive bridging faults and study the fault coverage on ISCAS85 circuits of different test sets using resistive and zero-ohm bridges at different supply voltages. These results explain several previously observed anomalous behaviors. In order to serve as a reference, we have developed the first resistive bridging fault ATPG, which attempts to detect the maximum possible bridging resistance at each fault site. We compare the results of the ATPG to the coverage obtained from other test sets, and coverage obtained by using the ATPG in a clean-up mode. Results on ISCAS85 circuits show that stuck-at test sets do quite well, but that the ATPG can still improve the coverage. We have also found that the loss of fault coverage is predominantly due to undetected faults, rather than faults in which only a small resistance is detected. This suggests that lower-cost fault models can be used to obtain high resistive bridge fault coverage.
Characterisation of microencapsulated Lactobacillus rhamnosus LR7 strain. (2003)

Survivability of free and microencapsulated Lactobacillus rhamnosus bacteria in different pH media was investigated. Microencapsulated bacteria were also subjected to freeze-drying. Encapsulation and freeze-drying are effective stabilisation methods increasing their resistance to environmental pH.
Ethanol enhances α <sub>4</sub> β <sub>3</sub> δ and α <sub>6</sub> β <sub>3</sub> δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans (2003)

gamma-Aminobutyric acid type A receptors (GABARs) have long been implicated in mediating ethanol (EtOH) actions, but so far most of the reported recombinant GABAR combinations have shown EtOH responses only at fairly high concentrations (> or = 60 mM). We show that GABARs containing the delta-subunit, which are highly sensitive to gamma-aminobutyric acid, slowly inactivating, and thought to be located outside of synapses, are enhanced by EtOH at concentrations that are reached with moderate, social EtOH consumption. Reproducible ethanol enhancements occur at 3 mM, a concentration six times lower than the legal blood-alcohol intoxication (driving) limit in most states (0.08% wt/vol or 17.4 mM). GABARs responsive to these low EtOH concentrations require the GABAR delta-subunit, which is thought to be associated exclusively with alpha 4- and alpha 6-subunits in vivo, and the beta 3-subunit, which has recently been shown to be essential for the in vivo anesthetic actions of etomidate and propofol. GABARs containing beta 2-instead of beta 3-subunits in alpha 4 beta delta- and alpha 6 beta delta-receptor combinations are almost 10 times less sensitive to EtOH, with threshold enhancement at 30 mM. GABARs containing gamma 2-instead of delta-subunits with alpha 4 beta and alpha 6 beta are three times less sensitive to EtOH, with threshold responses at 100 mM, a concentration not usually reached with social EtOH consumption. These combined findings suggest that "extrasynaptic" delta-subunit-containing GABARs, but not their "synaptic" gamma-subunit-containing counterparts, are primary targets for EtOH.
Recent Advances in Chemiluminescence (2007)

Abstract This article reviews the development and application of chemiluminescence (CL) published in the literature between January 2004 and October 2006, with regard to instrumentation, systems, applications, and conclusions.
The antipyretic effect of suprofen in rats with yeast-induced fever. (1975)

The antipyretic activity of alpha-methyl--4-(2-thienylcarbonyl)benzeneacetic acid (suprofen) was studied in rats with comparable hyperthermia after s.c. injection of brewer's yeast. The lowest dose effectively reducing fever is 5 mg/kg and restoration of normal body temperature is obtained with 40 mg/kg. Hypothermia is not observed even after treatment with 160 mg/kg. The ED50 (with confidence limits), which reduces fever below 39 degrees C in 50% of the animals, at the time of peak hyperthermia is 10.0 (6.6--15.2) mg/kg. ED50's of simultaneously studied reference compounds are 5.7 (3.9--8.3) mg/kg for indometacin, 38 (24--61) mg/kg for tolmetin, 76 (47--121) mg/kg for phenylburazone and 113 (75--170) mg/kg for acetyl-salicylic acid. Two to four times higher doses of these compounds restore normal body temperature but further increase of the dose induces hypothermia, which is particularly pronounced for acetyl-salicylic acid and phenylbutazone. Suprofen is a potent antipyretic agent, devoid of hypothermic activity even at 32 times the lowest effective dose.
Reactive oxygen species in melanoma and its therapeutic implications (2007)

Oxidative phosphorylation in the mitochondria is an important energy-producing process for eukaryotic cells, but this process can also result in producing potentially cell-damaging side products. Oxygen is the final proton acceptor in this cascade of electron/proton transfer and results in harmless water. The electron transfer, however, is not completely efficient and results in the production of reactive oxygen species (ROS). Low amounts of these ROS are important for cellular-signalling pathways. Excessive ROS, however, can induce cell damage that can culminate in cell death. Therefore, the cell has developed an antioxidant network to scavenge excessively produced ROS. In general, the balance between the production and scavenging of ROS leads to homeostasis. Disturbance of this equilibrium can alter normal cellular processes; it often occurs in tumour cells. In this review, the role of ROS in cutaneous melanoma development and progression is described. Cutaneous melanoma arises from epidermal melanocytes in skin, which is a relatively hypoxic tissue. ROS are generated as a result of increased metabolism of transformed cells, immune reaction against the developing tumour, ultraviolet radiation, melanin production and an altered antioxidant system. Knowledge of the role of ROS in melanoma development and the mechanisms that alleviate oxidative stress can aid in the development of better antimelanoma therapies.
Stator winding fault diagnosis in three-phase synchronous and asynchronous motors, by the extended Park's vector approach (2001)

This paper describes the use of the extended Park's vector approach (EPVA) for diagnosing the occurrence of stator winding faults in operating three-phase synchronous and asynchronous motors. The major theoretical principles related with the EPVA are presented and it is shown how stator winding faults can be effectively diagnosed by the use of this noninvasive approach. Experimental results, obtained in the laboratory, corroborate that these faults can be detected, in the EPVA signature, by the identification of a spectral component at twice the fundamental supply frequency. Onsite tests, conducted in a power generation plant and in a cement mill, demonstrate the effectiveness of the EPVA in the detection of these faults in large industrial motors, rated up to 5 MW.
Method of measuring travel time by using ultrasonic vehicle profile classifiers (1989)

As an approach to develop an effective real-time prediction system, a new system has been developed to measure the time used by vehicles to travel a certain section of a road. The system identifies special vehicles at the entrance and the exit of the section with ultrasonic vehicle classifiers. The first field experiment was made in 1986 at a section of 500 m length on the route 17 in Saitama Prefecture, and proved that the system was capable of measuring travel time. Further tests were conducted in 1987 and 1988 at the 1 to 3 km long sections of the route 17, and the maximum length of section applicable to the system was also studied. The conclusion of the tests was that the mean time for travelling a section of up to 2 km length has been obtained by using the system. Essentials of the tests are reported. >
Differential effects of acute and repeated citalopram in mouse models of anxiety and depression (2009)

Clinically, SSRIs are widely prescribed in the treatment of several anxiety disorders, although very few pre-clinical studies have observed a beneficial effect of this class of drugs in animal models of anxiety. Furthermore, the biphasic pattern observed clinically, an exacerbation of anxiety followed by beneficial effects, is rarely observed in animal studies. In the present study we document this clinical phenomenon in several behavioural paradigms. While a single injection of citalopram induced anxiogenic effects, three administrations of citalopram were sufficient to elicit anxiolytic effects. Congruent with these data, we observed that short-term repeated administration of citalopram was accompanied by increased activation of cAMP response element-binding protein (CREB) in the hippocampus and desensitization of 5-HT1A receptors, two phenomena well associated with chronic rather than acute actions of antidepressants. Moreover, effects of citalopram were abolished in CREBalphaDelta mutant animals in the elevated zero maze (EZM) and tail suspension test (TST), but not in novelty-induced hypophagia (NIH). Further, the desensitization of 5-HT1A receptors elicited by citalopram was not affected by CREB deficiency. The significance of the EZM and TST paradigms in predicting therapeutic efficacy is well known while effects in NIH and 5-HT1A sensitization are less well-established. These data demonstrate that behavioural responses to citalopram are dependent on the frequency of its administration, and that these responses are differentially dependent on CREB function.