gebhart/patrepeval huggingface dataset:
Cholesterol Biosynthesis Inhibitory Activities of Novel Triterpenoid Acids from<i>Kadsura heteroclita</i>and<i>K. longipedunculata</i> (1990)

The effects of twelve novel triterpenoid acids isolated from the ethanolic extract of the stems of Kadsura heteroclita and A. longipedunculata, Chinese folk medicines, and three other novel triterpenoid acids semi-synthesized on cholesterol biosynthesis were examined. (24Z)-3-Oxo-lanosta-8,24-dien-26-oic acid (3-oxo-LA) was most active in depressing cholesterol biosynthesis from [2-14C] mevalonate in a 10,000 × g supernatant fraction of rat liver homogenate. It was suggested from the TLC analysis of radio-labeled products that these compounds inhibit the demethylation of lanosterol. Some triterpenoid acids including 3-oxo-LA also inhibited cholesterol biosynthesis from [1-14C]acetate in primary cultures of rat liver cells.
Effects of molecular weight on selected physical properties of polyaromatic ether-ketones (1987)

Polyaromatic ether-ketones with various inherent viscosities were prepared and their thermal properties and stress–strain relationships were studied. It was found that the polymer should have an inherent viscosity greater than 0.8 in order to give flexible films, but there was no difference in thermal and stress–strain properties among polymers with viscosities greater than 0.8. Values of 110 MPa and 13% are considered to be the standard values of tensile strength and elongation, respectively, for these polyaromatic ether-ketones. The crosslinking effects on these properties were also studied, using polymers containing 1 and 5 mol % of crosslinkable biphenylene units, but no significant changes in the properties due to crosslinking were observed.
Incorporation of Proteins into Polymer Materials by a Novel Supercritical Fluid Processing Method (2002)

A very clean route to porous materials , utilizing the combination of conventional solution and supercritical fluid processing, is exploited to prepare porous tissue engineering scaffolds that contain biologically active material for controlled release. This allows accurate dosing of the biological agent, whilst retaining the advantages of supercritical fluid technology. The retention of biological activity throughout the processing is also demonstrated. A wide range of alternative morphologies, including microparticles, are possible simply via control of the method of depressurization.
Metal–metal interactions in 2–Fe ferredoxins; SCF-Xα-SW calculations (1978)

SCF–Xα–SW calculations on Fe2S2(SH)42– show that (i) the antiferromagnetism of 2–Fe ferredoxins is due to superexchange rather than direct Fe–Fe overlap; (ii) the weak direct Fe–Fe bonding present is concentrated not in the Fe 3d band, but in a lower lying, mainly Fe–(bridging S) orbital.
Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels (1979)

In view of the potent influences of the central nervous system on glucose metabolism and on its hormonal regulators, and our recent finding of insulin and insulin receptors throughout the central nervous systsem, we have examined extreme conditions of hyperinsulinemia (obese mice) and hypoinsulinemia (streptozotocin-treated rats) with respect to changes in brain insulin and receptor content. Sprague-Dawley rats given streptozotocin (100 mg/kg body wt) developed severe diabetes and by 48 h showed no change in brain insulin. Rats given 65 mg/kg streptozotocin also had severe diabetes, but survived longer. Both at 7 d and at 30 d after streptozotocin treatment there was no significant change in brain insulin or in brain content of insulin receptors, despite the fact that peripheral hepatic receptors were elevated and pancreatic insulin was markedly depleted. The obese mice were studied at 8-10 wk when peripheral plasma insulin concentrations were 50-fold elevated and receptors on peripheral target cells were reduced to congruent with40-50% of normal; brain insulin concentrations and receptor content were indistinguishable from those of thin littermates. Thus, brain insulin, which is typically 10 times higher than plasma insulin concentrations, and brain receptor content, which is equivalent to receptor content on peripheral tissues, appears to be regulated entirely independently of hormone and receptor in the periphery. These findings are consistent with the hypothesis that insulin in the central nervous system is synthesized by the neural elements, and plays a role in the central nervous system which is unrelated to peripheral glucose metabolism.
The leech Batracobdelloides tricarinata (Blanchard, 1897) (Hirudinea: Glossiphoniidae) as a possible reservoir of the rainbow trout pathogenic Streptococcus species. (1989)

A Streptococcus species biochemically and serologically identical to the rainbow trout pathogenic Streptococcus species was isolated from the internal organs of the fish specific leech, Batracobdelloides tricarinata. These leeches were obtained from Roodeplaat Dam, near Pretoria, in which rainbow trout do not occur. This is the first isolation of this bacterium from an environmental source not related to rainbow trout and it is proposed that this leech is a possible reservoir of the rainbow trout pathogenic Streptococcus sp. in South Africa.
Response Surface Methodology to Supercritical Carbon Dioxide Extraction of Essential Oil from<i>Amormum krevanh Pierre</i> (2009)

Abstract Response surface methodology was employed to investigate the effects of operating conditions and predict the optimal conditions for supercritical carbon dioxide extraction of essential oil from Amomum krevanh Pierre. The factors investigated were operating temperature (33–67°C), the operating pressure (91–259 bar), and the extraction time (20–70 min). The main effect of the operating pressure and the interaction effect between the operating temperature and the extraction time were found to be significant factors. From the response surface model, an optimal condition for essential oil content within the range of experimental study was found to be at 33°C, 175 bar, and 70 min, which gave the oil yield of 17.3 mg/g dry wt. The essential oil yield obtained at all conditions were higher than that obtained by organic solvent extraction (9.74 mg/g dry wt.) while the composition of the extract was similar, which were 1,8-cineole (70.87%), β-pinene (8.89%), and limonene (4.81%). Keywords: Cardamom1,8-cineoleextractionoptimizationorthogonal design ACKNOWLEDGEMENTS The authors thank Thailand Research Fund and The Commission of Higher Education for financial support. Notes R Squared = .985 (Adjusted R Squared = .878) R Squared = .709.
Melting Point of Carbon Tetrachloride (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMelting Point of Carbon TetrachlorideA. K. DunlopCite this: J. Am. Chem. Soc. 1955, 77, 7, 2016Publication Date (Print):April 1, 1955Publication History Published online1 May 2002Published inissue 1 April 1955https://pubs.acs.org/doi/10.1021/ja01612a094https://doi.org/10.1021/ja01612a094research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Primary Myoepithelioma of Bone (2013)

The clinical and pathologic features of 8 primary myoepitheliomas of bone were analyzed. There were 5 female and 3 male patients who ranged in age from 16 to 49 (mean, 33.5) years. Three tumors arose in the ilium, 2 in the tibia, and 1 each in the maxilla, sacrum, and L1 vertebral body. Microscopically, the tumors had a solid, lobulated, reticular, or storiform growth pattern and were predominantly composed of spindle-shaped cells arranged in intersecting fascicles with eosinophilic cytoplasm. The round to polygonal epithelioid cells were arranged randomly or formed small clusters and contained variable amounts of eosinophilic or clear cytoplasm. Immunohistochemically, all the tumors were positive for vimentin and S100 protein, and 7 were positive for epithelial membrane antigen. No tumors were positive for keratin (AE1.3/CAM5.2). Smooth muscle actin was positive in 3 tumors and negative in 4, whereas desmin was negative in all 7 tumors tested. Nuclear staining for p63 was negative in 3 tested tumors. Staining for GFAP and CD34 was performed on 4 and 5 tumors, respectively, and all showed no expression. Fluorescence in situ hybridization for EWSR1 rearrangement was performed in 7 tumors. Five tumors (71%) showed the presence of EWSR1 gene rearrangement, and 2 were negative. Cytogenetic studies conducted on 1 tumor showed 46,XY,t(1;22)(q21;q12) associated with EWSR1-PBX1 fusion. Surgical procedures included curettage in 3 patients, resection in 3 patients, and 2 patients only had an open biopsy. Follow-up information was available for 4 patients; all remain free of disease with no recurrence. Although experience with primary myoepithelioma of bone is limited, histologically, banal tumors appear to behave in a benign manner, and conservative surgery appears to be sufficient treatment. Immunohistochemical and molecular analyses are helpful in their accurate identification.
Macroporous gels. 1. Polymerization of trimethylolpropane trimethacrylate in toluene (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMacroporous gels. 1. Polymerization of trimethylolpropane trimethacrylate in tolueneJ. E. Rosenberg and P. FlodinCite this: Macromolecules 1986, 19, 6, 1543–1546Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/ma00160a011https://doi.org/10.1021/ma00160a011research-articleACS PublicationsRequest reuse permissionsArticle Views317Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Energy Metabolism and Cellular pH in Normal and Pathological Conditions. A New Look Through <sup>31</sup> Phosphorus Nuclear Magnetic Resonance (1982)

Cellular energetics can be studied non-invasively using 31P nuclear magnetic resonance (NMR). Besides the concentration of the major phosphorus-containing metabolites, enzyme-catalysed fluxes and intracellular pH can be obtained from the NMR measurement. Metabolic acidosis in the ischaemic myocardium has been studied in the perfused rat heart. Comparison of the pH, measured from the position of the inorganic phosphate (Pi) resonance, with the pH obtained from the resonance of 2-deoxyglucose 6-phosphate (accumulated after perfusion with 2-deoxyglucose) demonstrates that cytoplasmic pH values are being obtained. The pH changes during ischaemia are quantitatively related to the glycogen leads to lactate conversion. Preperfusion with insulin enhanced the lactate production but resulted in the maintenance of ATP for a longer period during ischaemia, even though acidosis was enhanced. In acute renal acidosis, the decrease in intracellular pH is smaller than might have been expected, as demonstrated in the perfused rat kidney. The importance of acidosis in relation to renal preservation was examined in human kidneys prior to transplantation. 31P NMR studies on human forearm muscle have been done. The pH changes measured during aerobic and anaerobic exercise demonstrate the importance of glycogenolysis in providing energy for ATP production. In a patient with suspected McArdle's syndrome, 31P NMR was used to detect the lack of glycogenolysis since during both aerobic and anaerobic exercise a pH rise was observed together with the rapid breakdown of phosphocreatine.
Impact of Interpatient Pharmacokinetic Variability on Design Considerations for Therapy with Radiolabeled MAbs (2003)

Radionuclides provide biologically-distributed vehicles for radiotherapy of multifocal cancer. Two algorithms, fixed vs individualized, have been used to prescribe the therapeutic dose of radionuclide (GBq) for the patient. The individualized method for prescribing radionuclide dose takes variations in drug pharmacokinetics into consideration, whereas the fixed method depends, in part, on documentation that there is little interpatient pharmacokinetic variability for the radiolabeled drug. Two data bases, selected to compare iodine-131((131)I) and indium-111((111)In) labeled MAbs, were used to assess interpatient pharmacokinetic variability and its impact on radionuclide dose prescription. Pharmacokinetic data obtained over 7 days for non-Hodgkins lymphoma (NHL) patients given (131)I-Lym-1 (n = 46) or (111)In-Lym-1 (n = 13) were used to obtain cumulated activities. Although (131)I-Lym-1 often showed greater interpatient variability, (111)In-Lym-1 showed several-fold variability for many tissues. Both (131)I- and (111)In-Lym-1 had sufficient interpatient variability to be significant for radionuclide dose prescription, depending on the dose-limiting critical tissue. Interpatient variability exceeded intra- and interoperator variability and intrapatient variability over time for a single institution. In summary, the magnitude of interpatient pharmacokinetic variability for (131)I- and (111)In-Lym-1 suggested that an optimally safe and effective therapy can be best achieved when radionuclide dose is influenced by estimated radiation dose, if the latter is reproducible from institution to institution.
Active Filters Operating below 1 Hz (1967)

Second-order RC filters are synthesized using two voltage amplifiers with gains A1 and A2. As the natural frequency depends on A1 only, and the damping factor depends on A1 and A2, these factors can be chosen consecutively by varying the two gains. The passive components need not have variable or accurate values. This feature is particularly useful in the realization of filters operating below 1 Hz, and cutoff frequencies down to at least 10-3 Hz can be obtained by exploiting the high input resistance of MOS transistors.
Suppression of growth of hepatocellular carcinoma by sodium butyrate in vitro and in vivo (1998)

Treatment of HuH-7 human hepatocellular carcinoma (HCC) cells with 1-10 mM sodium butyrate (SB) resulted in growth inhibition in a dose-dependent manner. At 3 mM and higher concentrations, SB caused nuclear fragmentation and DNA ladder formation characteristic of apoptosis. In the treated cells, the expression of p21 (WAF1/CIP1) increased and that of -fetoprotein (AFP) decreased. These characteristic changes were also observed with 5 other human HCC cell lines with or without mutation of the p53 gene. The ability of these cells to form colonies in soft agar was suppressed by either pretreating the cells with SB prior to soft agar plating or incubating untreated cells in SB-containing soft agar. Direct injection of SB into tumors developed from HuH-7 cells in nude mice resulted in an increase in the p21 level, a decrease in the tumor size and an increase in the survival time of mice. When the inoculation of HuH-7 cells into nude mice was immediately followed by subcutaneous injection of SB, development of tumors was either significantly delayed or completely suppressed. These results suggest that SB induces cellular differentiation and suppresses growth and tumorigenicity of HCC cells in vitro and in vivo by a mechanism independent of p53 but possibly dependent on p21. Int.
Complete mitochondrial genomes of the ‘intermediate form’ of Fasciola and Fasciola gigantica, and their comparison with F. hepatica (2014)

The mt genomes characterized here provide a rich source of markers, which can be used in combination with nuclear markers and imaging techniques, for future comparative studies of the biology of Fasciola sp. from China and other countries.
Benign prostatic disease (1993)

All of your male patients may one day be concerned with the prospect of prostatic disease. How can you as a primary care physician best approach evaluation and treatment of these disorders? Drs Daneshgari and Crawford provide the information you need to know about recognition and management of benign prostatic hyperplasia and common types of prostatitis.
Effects of Alloying Elements on Static Recrystallization Behavior of Work Hardened Austenite of High Carbon Low Alloy Steel (2016)

Many studies have investigated the effect of alloying elements on the recrystallization behavior of work hardened austenite. However, the recrystallization behavior of high carbon low alloy steel has not been systematically investigated yet. In this study, the effects of alloying elements (Al, Nb, V, Ti and B) are examined by means of double hit compression test, TEM and 3DAP (Three-dimensional atom probe) analyses. The following conclusions were obtained: (1) When alloying elements are in solid solution, Nb and Ti has equally strong effects on inhibiting recrystallization, followed by V. (2) When deformation and holding temperature becomes low, the recrystallization is remarkably inhibited by adding 0.1%V. (3) Fine particles were not observed by 3DAP observation in the 0.1%V steel which shows the strong inhibition effect on recrystallization. The solute V content measured by 3DAP decreased as the holding time increased and, recrystallization commenced at the time when relatively coarse precipitates formed.
Frequency Tuning of Unimorph Cantilever for Piezoelectric Energy Harvesting (2007)

Piezoelectric energy harvesting from our surrounding vibration has been studied for driving the wireless sensor node. To change the vibration energy into the electric-energy efficiently, the natural frequency of cantilever needs to be adjusted to that of a vibration source. When adding 6.80g mass on the end of the fabricated cantilever, a natural frequency shifts from 136 Hz into 49.5 Hz. In addition, electro-mechanical coupling factor increased from 10.20% to 11.90% and resulted in the 1.18 times increase of maximum output power.
ChemInform Abstract: REACTIONS INVOLVING FLUORIDE ION PART 6, REACTIONS OF TETRAFLUOROETHYLENE WITH PENTAFLUOROPYRIDINE AND TETRAFLUOROPYRIDAZINE (1973)

Abstract Das Pyridin (I) reagiert mit dem Äthylen (II) hauptsächlich zu einem Gemisch der Perfluoräthylpyridine (III)‐(V) (ca.
Selective sulfate binding induces helical folding of an indolocarbazole oligomer in solution and solid state (2009)

Hydrogen bonding to anions drives the helical folding of an indolocarbazole oligomer, thus resulting in an internal cavity with six NHs and two OHs for binding sulfate with high selectivity.
Hyperoxia and In-vitro Bone Resorption (1968)

* Department of Orthopedic Surgery, Harvard Medical School, The Massachusetts General Hospital, Boston, Mass.
Parallel combinatory OFDM signaling (1999)

A parallel combinatory-orthogonal frequency division multiplexing (PC-OFDM) system is proposed and analyzed. The proposed system selects at each symbol interval a subset of the available subcarriers, and the selected subcarriers are modulated by points from an M-PSK signal constellation, PC-OFDM systems can be designed to have lower peak-to-average power ratio (PAPR), higher bandwidth efficiency, and lower bit error probability on Gaussian channels compared to ordinary OFDM systems. A bit mapping procedure using the Johnson (1993) association, together with a position algorithm for the PSK symbols, is proposed. Good analytical approximations of the BER for PC-OFDM systems are derived for AWGN and Ricean fading channels, and extensive simulation results are presented.
Ecophysiology of Eucalyptus marginata and Corymbia calophyllain decline in an urban parkland (2009)

The enzyme gamma-glutamyltransferase (GGT) is frequently overexpressed in cancer cells and tissues and has significant utility as a cancer marker. Significant heterogeneity of the enzyme has been described due to both transcriptional and post-translational variations. For possible use in diagnosis and follow-up of patients with colorectal cancer, a search was performed for specific mRNA subtypes and glycan structures of the enzyme in liver metastases. We found no differences in the distribution of three GGT mRNA subtypes (fetal liver, HepG2, placenta) in metastatic tissue and normal liver tissue. Furthermore, the three subtypes were present in leukocytes isolated from both normal individuals and cancer patients. Two colon carcinoma cell lines (Colo 205 and HCC 2998) also displayed the three forms and no consistent changes in mRNA composition were noted after butyrate-induced differentiation of the cells. Thus, neither of the GGT mRNA subforms appear to be tumor-specific, although some qualitative and quantitative variations were noted. Two distinct glycosylation features were detected for GGT in metastatic tissue in contrast to normal liver GGT; an extreme sialic acid heterogeneity and a significant increase in beta1,6GlcNAc branching. The GGT glycans from the two colon carcinoma cell lines also possessed these features. As butyrate treatment of the cells resulted in an increased sialic acid content and a reduced beta1,6GlcNAc branching, the described carbohydrate structures appear to be part of a tumor-related pattern. We were, however, unable to identify such GGT isoforms in serum from patients with advanced colorectal cancer. This indicates that their usefulness in diagnostic use is doubtful.