gebhart/patrepeval huggingface dataset:
Effect of Surface Roughness on Eddy Current Losses at Microwave Frequencies (1949)

A theoretical investigation has been made of the power dissipation by eddy currents in a metallic surface at microwave frequencies in the presence of regular parallel grooves or scratches whose dimensions are comparable to the eddy current skin depth. The eddy current equation has been integrated numerically for grooves of various shapes and sizes transverse to the direction of induced current flow, and the corresponding losses are calculated and plotted. The power dissipation is increased by about 60 percent over its value for a smooth surface when the root-mean-square deviation of the grooved surface from an average plane is equal to the skin depth; the exact shape of the grooves is not critical. The increase in eddy current losses caused by grooves parallel to the current is shown in a particular case to be only about one-third as great as the increase caused by transverse grooves of similar size. The effect on losses of an isolated narrow crack or fissure transverse to the current is briefly discussed.
Photo-Chromeleon: Re-Programmable Multi-Color Textures Using Photochromic Dyes (2020)

In most situations in the real world, once an object is fabricated, the color is permanent and cannot be changed again. For the Emerging Technologies exhibit, we will present a technology to create re-programmable multi-color textures that are made from a single material only. This technology is based on photochromic dyes that can switch their appearance from transparent to colored when exposed to the light of a certain wavelength. By mixing cyan, magenta, and yellow (CMY) photochromic dyes into a single solution and leveraging the different absorption spectra of each dye, we can control each color channel in the solution separately. Our approach can transform single-material fabrication techniques, such as coating, into high-resolution multi-color processes. In addition, as the color-changing process is fully reversible, users can recolor objects multiple times.
Differential distributions of two adducin-like protein isoforms in the<i>Drosophila</i>ovary and early embryo (1996)

Adducin is a cytoskeletal protein that can function in vitro to bundle F-actin and to control the assembly of the F-actin/spectrin cytoskeletal network. The Drosophila Adducin-like (Add) locus (also referred to as hu-li tai shao (hts)) encodes a family of proteins of which several are homologous to mammalian adducin (Ding et al., Proc. Natl. Acad. Sci. USA 90, 2512-16, 1993; Yue & Spradling, Genes Dev. 6, 2443-54, 1992). We report the identification of two novel adducin isoforms: a 95 x 10(3) Mr form (ADD-95) and an 87 x 10(3) Mr form (ADD-87). We present a detailed analysis of the distribution patterns of ADD-95 and ADD-87 during oogenesis and embryogenesis. The isoforms are co-expressed in several cell- and tissue-types; however, only ADD-87 is present in mid- to late-stage oocytes. ADD-87 is present throughout the oocyte cortex at stages 9 and 10 of oogenesis but is detectable only at the anterior pole from stage 11 onward, correlated with localisation of Add-hts mRNA first to the cortex and then to the anterior pole of the oocyte. ADD-87 co-localises with F-actin and spectrin in the cortex of the oocyte through stage 10 of oogenesis, consistent with a possible role in cytoskeletal assembly or function predicted by mammalian studies.
Antitumor activity of NVP‐AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins (2011)

Heat shock protein 90 (HSP90) is a molecular chaperone required for the stability of key regulators of cell survival and is an emerging target of cancer therapy. NVP-AUY922, a novel and potent inhibitor of HSP90, was evaluated against gastric cancer cell lines. NVP-AUY922 significantly inhibited the proliferation of all tested gastric cancer cell lines with 50% inhibitory concentration in the range of 2-40 nM and potently induced the degradation of growth factor receptors and other client proteins including HER-2, Akt and thymidylate synthase. HSP70 was induced by NVP-AUY922 and its binding with client proteins led to their proteasomal degradation. Moreover, the combination of NVP-AUY922 with cytotoxic chemotherapeutic agents such as 5-fluorouracil and oxaliplatin created a synergistic effect. Taken together, these preclinical data demonstrate the potent activity of NVP-AUY922 against gastric cancer cells and offer a rationale for clinical development of the agent alone or in combination with other chemotherapeutic drugs to effectively treat gastric cancer.
Sensorem - an efficient mobile platform for wireless sensor network visualisation (2015)

We design and implement an Android application, Sensorem, for efficient retrieval and visualization of wireless sensor network (WSN) data. In light of data distribution and visualization being important developmental keystones of smart cities, we seek to enhance sensor data accessibility by developing a user-friendly mobile application (Sensorem) for meaningful visualization of sensor data, targeted at maintenance personnel. Sensor selection can be made with reference to geographical location through an embedded Google Map fragment, as well as a sensor list with sensors in order of WSN node ID. Sensor data is presented through interactive graphs, and graph overlaying functions are offered for easy comparison of data trends. We also employ a Bayesian prefetch algorithm and caching mechanisms to minimize sensor data access latency, such that the app system is able to cope with network and back-end bottlenecks.
[Automatic reading of ABO and Rh groups on microplates using FMC medium and an IBG Systems reader]. (1991)

We present in this paper our experience in the routine use of an automatic reader for microtiter plates (IBG Systems). A total of 2044 samples from blood donors have been tested for ABO (haematic and seric) and Rh (D antigen) blood group typing. The red blood cell samples have been tested against monoclonal anti-A, anti-B, anti-AB and anti-Rh 1 (D) sera (using two different anti-D reagents). As a negative control, 3% albumin solution was employed. In order to determine the seric groups, the plasma samples were tested against A1, A2, B and 0 cells. In all cases the red cells were suspended in Ficoll 400R-Methyl cellulose (FMC), and 0.01 Bromelin was added to red blood cell samples to be typed. The obstacles in the automatic readings were mainly solved by visual reading of the microplates. In the 2,044 samples analysed with the automatic reader, 19 discrepancies (0.94%) were found in ABO typing. In all cases the error was in the seric blood group. Three false positive reactions were found with 0 red cells. Two false negative with B red cells, interpreted by the automatic reader as doubtful results. Three positive readings were detected, in one case the positivity was due to alloantibodies (C + D specificities), the other two cases were autoagglutinations. False negative reactions were found, in 11 cases, 8 of them due to lipaemia and the remaining three were haemolysed plasma samples. It should be stressed that out of 19 cases of discrepancy, only 5 (0.24%) were due to the automatic reader while the remaining were due, to sample troubles.(ABSTRACT TRUNCATED AT 250 WORDS)
Effects of buspirone and alprazolam on the cognitive performance of normal elderly subjects (1991)

Buspirone did not produce behavioral side effects that could lead to disability, and alprazolam had minimal side effects. Because the patients were carefully screened, it is unclear whether these medications in the doses used would have more side effects in less healthy elderly patients.
The Application of the Uniform Declaratory Judgments Act in Montana (1947)

The Application of the Uniform Declaratory Judgments Act in Montana
A specification logic for dynamic composition of services (2002)

We focus on a composition model for services, which are composed of pre-programmed service components represented as Java classes. A common formal basis for representing the semantics of dynamic composition of services from service components is presented. We propose a logic and a specification language that enable us to reason about and deploy service components automatically. The proposed composition model uses a logical proof as witness for the correct deployment of service components in the context of their use. The composition model has been implemented in Java as an environment for dynamic composition of services. We illustrate the proposed composition method on an example of composition of a service.
Physical Principles of Remote Sensing (2001)

This new edition textbook explains remote sensing of the Earth's surface and atmosphere from space using electromagnetic radiation. It covers topics such as overviews of electromagnetic propagation in free space and in matter, surface and volume scattering, the interaction of radiation with the atmosphere, the main classes of sensor, satellite orbits for remote sensing, and an introduction to image processing. Extensively revised and expanded, the second edition contains completely new material, including a discussion of the radiative transfer equation, atmospheric sounding techniques and interferometric radar and a discussion of GPS. Also including numerous problems with solutions, this book forms the basis of an introductory course for students in remote sensing, geography, cartography, surveying, meteorology, earth sciences and environmental sciences. It will also be an essential reference for researchers and a useful supplementary text in some physics, mathematics and engineering courses.
Antibody–drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes (2018)

Targeted delivery of therapeutic molecules into cancer cells is considered as a promising strategy to tackle cancer. Antibody-drug conjugates (ADCs), in which a monoclonal antibody (mAb) is conjugated to biologically active drugs through chemical linkers, have emerged as a promising class of anticancer treatment agents, being one of the fastest growing fields in cancer therapy. The failure of early ADCs led researchers to explore strategies to develop more effective and improved ADCs with lower levels of unconjugated mAbs and more-stable linkers between the drug and the antibody, which show improved pharmacokinetic properties, therapeutic indexes, and safety profiles. Such improvements resulted in the US Food and Drug Administration approvals of brentuximab vedotin, trastuzumab emtansine, and, more recently, inotuzumab ozogamicin. In addition, recent clinical outcomes have sparked additional interest, which leads to the dramatically increased number of ADCs in clinical development. The present review explores ADCs, their main characteristics, and new research developments, as well as discusses strategies for the selection of the most appropriate target antigens, mAbs, cytotoxic drugs, linkers, and conjugation chemistries.
Synthetic Literature: Writing Science Fiction in a Co-Creative Process (2017)

This paper describes a co-creative text generation system applied within a science fiction setting to be used by an established novelist. The project was initiated as part of The Dutch Book Week, and the generated text will be published within a volume of science fiction stories. We explore the ramifications of applying Natural Language Generation within a cocreative process, and examine where the cocreative setting challenges both writer and machine. We employ a character-level language model to generate text based on a large corpus of Dutch novels that exposes a number of tunable parameters to the user. The system is used through a custom graphical user interface, that helps the writer to elicit, modify and incorporate suggestions by the text generation system. Besides a literary work, the output of the present project also includes user-generated meta-data that is expected to contribute to the quantitative evaluation of the text-generation system and the co-creative process involved.
Chapter 14. Copper (1992)

D. W. Smith, Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem., 1992, 89, 195 DOI: 10.1039/IC9928900195
Actin Interacting Protein1 and Actin Depolymerizing Factor Drive Rapid Actin Dynamics in<i>Physcomitrella patens</i>  (2011)

The remodeling of actin networks is required for a variety of cellular processes in eukaryotes. In plants, several actin binding proteins have been implicated in remodeling cortical actin filaments (F-actin). However, the extent to which these proteins support F-actin dynamics in planta has not been tested. Using reverse genetics, complementation analyses, and cell biological approaches, we assessed the in vivo function of two actin turnover proteins: actin interacting protein1 (AIP1) and actin depolymerizing factor (ADF). We report that AIP1 is a single-copy gene in the moss Physcomitrella patens. AIP1 knockout plants are viable but have reduced expansion of tip-growing cells. AIP1 is diffusely cytosolic and functions in a common genetic pathway with ADF to promote tip growth. Specifically, ADF can partially compensate for loss of AIP1, and AIP1 requires ADF for function. Consistent with a role in actin remodeling, AIP1 knockout lines accumulate F-actin bundles, have fewer dynamic ends, and have reduced severing frequency. Importantly, we demonstrate that AIP1 promotes and ADF is essential for cortical F-actin dynamics.
A Topography/Chemical Composition Gradient Polystyrene Surface:  Toward the Investigation of the Relationship between Surface Wettability and Surface Structure and Chemical Composition (2007)

In this paper, we have prepared of a topography/chemical composition gradient polystyrene (PS) surface, i.e., an orthogonal gradient surface, to investigate the relationship between surface wettability and surface structure and chemical composition. The prepared surface shows a one-dimensional gradient in wettability in the x, y, and diagonal directions, including hydrophobic to hydrophilic, superhydrophobic to hydrophobic, superhydrophobic to superhydrophilic gradients, and so forth. These one-dimensional gradients have different gradient values, gradient range, and contact angle hysteresis, which lie on both the surface roughness and the surface compositions. From the trend of variation of contact angle hysteresis, it can be concluded that the transition from the Cassie's model to the Wenzel's model occurs both by decreasing surface roughness and by increasing surface hydrophilic compositions. Moreover, the transition is more effective via changing surface chemical composition than changing surface roughness herein.
Direct microtiter plate sequencing of PCR-amplified M13 clones from plaques using dried reagents. (1992)

A method is described using dried reagents in microtiter plates for direct PCR and sequencing of M13 plaques. The method has advantages of reliability and high throughput that make it suitable for medium to large-scale sequencing projects.
Total blood flow to arteriovenous malformations (1993)

Normal perfusion pressure breakthrough is considered to be a great hazard during or after resection of large arteriovenous malformations (AVMs). This article presents the total blood flow to the AVMs, particularly those of greater than 3 cm in diameter (greater than 14.1 cm3 in volume), which have multiple compartments. The total blood flow into the AVMs in the sensory-motor area in 6 patients averaged 830 +/- 285 cc/min and those in the visual area in 4 patients averaged 358 +/- 33 cc/min. These flow values were compared to total flow through the intracranial arteries (756 cc/min). Large volume of blood flow into the AVMs carries a significant post-operative risk of normal profusion pressure breakthrough. Redistribution of blood flow from large AVMs into the cerebrovascular bed is an important factor for circulatory regulation to occur after their resection. The risk of normal profusion pressure breakthrough must be minimized by surgical technique discussed in the text.
Reaktion von Acetophenonmonomethyl- und -dimethylhydrazonen mit dem Vilsmeier-Reagenz; Bildung von Pyrazol-4-carbiminiumsalzen: ein Beitrag zum Mechanismus (2000)

Reactions of Acetophenonmonomethyl- and -dimethylhydrazones with the Vilsmeier-Reagent; Formation of Pyrazol-4-carbiminium Salts: A Contribution to the Mechanism Kira discovered the formation of (4e) N,N-Dimethyl-N-[1,3-diphenylpyrazol-4-ylmethylen]ammonium perchlorat by the reaction from acetophenonphenylhydrazone 1e with the Vilsmeier-Reagent 2. On the example of the Acetophenonmonomethylhydrazone 1a we represent the mechanism of this reaction. 1a reacts with the Vilsmeier-Reagent 2 firstly to 3a (scheme 1). 3a is formylated in the secondary step by 2 on the methyl group of the acetophenon part followed of a ring conclusion to the pyrazol 4a containing a carbiminium group in position 4 as substituent. 3a doesN′t react to 6a directly. Hydrolysis of 4a gives 5a. We found moreover, that acetophenondimethylhydrazones 8 react with 2 to 4, too (scheme 2, eq 2). But here the proton of the methylamino group in 1 is occupied by the methyl group in 8. Therefore, the reaction starts in this case with an attack on the methyl group of the acetophenon part followed of the ringconclusion to the intermediate 6 accompanied of the eli-mination of the methyl group. In the last step the not isolated pyrazol 6 is formylated by 2 in 4-position to 4. In a secondary reaction from 8 with 2 the compounds 9 are formed (scheme 2, eq. 3). 9 are intermediates in the reaction from 8 to 4 only in a small extent.
DEGRADATION OF DEOXYRIBONUCLEIC ACID BY HOT ALKALI (1958)

An extensive destruction of deoxyribonucleic acid has been observed during prolonged treatment with 1 N sodium hydroxide at 100° C. After 4 hours of hot alkaline hydrolysis there was complete destruction of cytosine, only about 50% of which could be accounted for by conversion to uracil; adenine was destroyed to the extent of 60% without deamination to hypoxanthine, whereas guanine and thymine were not affected. The diphenylamine color test for deoxyribose showed a decrease of 35% and a similar decrease was obtained with the cysteine – sulphuric acid test. A decrease of 26% in the ultraviolet light absorption corresponded to the value calculated on the basis of the destruction of the purine and pyrimidine bases.
Next-generation MicroRNA expression profiling technology : methods and protocols (2012)

The rapid pace of microRNA (miRNA) research continues to drive the advances of techniques for miRNA expression profiling, and innovative technologies that are more sensitive, specific, quantitative, and that are compatible with a wide range of biospecimens have been developed during the past few years. In Next-Generation MicroRNA Expression Profiling Technology: Methods and Protocols, expert researchers in the field contribute detailed examinations of the most current approaches being used today. This volume includes comprehensive coverage of methodologies that have been developed for miRNA profiling, as well as next-gen sequencing technology, miRNA databases, and specialized applications, such as cancer studies and miRNA-based non-invasive biomarker development. Written in the highly successful Methods in Molecular Biology™ series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Next-Generation MicroRNA Expression Profiling Technology: Methods and Protocols provides an ideal guide for novices and experts alike who are seeking to utilize these powerful technologies
Comparison of vedaprofen and meloxicam in dogs with musculoskeletal pain and inflammation (2002)

In this randomised, multicentre clinical study, dogs with musculoskeletal pain and inflammation were treated with either vedaprofen or meloxicam administered orally at the recommended dose rates. Clinical examinations were carried out regularly and clinical severity scores assigned. In total, 214 cases (73 acute, 141 chronic) were evaluated. Treatment with vedaprofen and meloxicam was continued for 14 and 17 days, respectively, in the acute cases, and 38 and 39 days in the chronic cases. NSAID treatment resulted in a significant improvement in clinical scores. The overall response to treatment ('responders') at the final clinical examination was 89 per cent and 87 per cent in the acute cases and 72 per cent and 65 per cent in the chronic cases in the vedaprofen and meloxicam groups, respectively. Mild transient gastrointestinal signs were observed in both groups (11 per cent vedaprofen, 12 per cent meloxicam). Adverse effects related to NSAIDs resulted in treatment cessation in 5 per cent of the dogs in each group. Vedaprofen and meloxicam were efficacious in, and well tolerated by, most of the dogs in the study.
Crystallinity changes during PVC processing (1989)

Abstract Thermal analysis, solvent sorption, density measurement, and X‐ray diffraction techniques were used to investigate structural changes in a variety of PVC compounds which were extruded or compression‐molded at temperatures in the range 150–220°C. In all cases processing at lower temperatures in this range resulted in a disappearance of primary crystallinity and a concomitant development of secondary crystallinity, of lower order. In many cases processing above 190–200°C caused a small increase in crystallinity. It is believed that this is more ordered secondary crystallinity, which is therefore detectable by X‐ray diffraction and also capable of influencing density and solvent sorption behavior. The observed structural behavior depends on shear as well as temperature. Primary crystallinity is higher in compression moldings, which have experienced lower shear levels, and the increase in crystallinity at higher temperatures is also greater. Equilibrium solvent sorption depends on the presence of primary and ordered secondary crystallinity. Diffusion is, however, unaffected as it occurs through amorphous and disordered crystalline regions only.
A Personalized Framework for Medication Treatment Management in Chronic Care (2009)

The ongoing efforts toward continuity of care and the recent advances in information and communication technologies have led to a number of successful personal health systems for the management of chronic care. These systems are mostly focused on monitoring efficiently the patient's medical status at home. This paper aims at extending home care services delivery by introducing a novel framework for monitoring the patient's condition and safety with respect to the medication treatment administered. For this purpose, considering a body area network (BAN) with advanced sensors and a mobile base unit as the central communication hub from the one side, and the clinical environment from the other side, an architecture was developed, offering monitoring patterns definition for the detection of possible adverse drug events and the assessment of medication response, supported by mechanisms enabling bidirectional communication between the BAN and the clinical site. Particular emphasis was given on communication and information flow aspects that have been addressed by defining/adopting appropriate formal information structures as well as the service-oriented architecture paradigm. The proposed framework is illustrated via an application scenario concerning hypertension management.
Biological Characterization of Chicken Insulin Activity in Rats and Domestic Fowl (1968)

Crystalline insulin prepared from chicken pancreas was as active as crystalline beef, sheep and pork insulins in an in vitro rat diaphragm bioassay, but was considerably more effective in promoting hypoglycemia in intact chickens when compared with equivalent amounts (by weight) of mammalian hormone. Primary structure differences among various species of insulin and interfering plasma substances are discussed with respect to the oft-reported avian “resistance” to non-avian insulin. (Endocrinology83: 1331, 1968)