gebhart/patrepeval huggingface dataset:
Clinical Sindbis alphavirus infection is associated with HLA-DRB1*01 allele and production of autoantibodies (2012)

Background: Arthropod-borne Sindbis virus (SINV) is a mosquito-borne enveloped single-stranded RNA virus of the genus Alphavirus, family Togaviridae. SINV is found in Eurasia, Africa and Oceania but clinical SINV infection, characterized by arthropathic disease that may persist for years, is primarily reported in Northern Europe where the disease has considerable public health importance in endemic areas. Only a few studies have characterized host genetic determinants associated with alphavirus infections. We aimed to investigate the role of genetic factors in the susceptibility and outcome of SINV infection and to elucidate the association between SINV infection and autoimmunity. Methods: The study consisted of 49 patients with serologically confirmed symptomatic SINV infection who were followed over three years after acute infection. HLA genes reported to have an associated with rheumatic and infectious diseases and complement C4 genes were determined in 35 patients. Furthermore, a set of autoantibodies were measured at the acute phase and 3 years after infection in 44 patients. Results: The frequency of DRB1*01 was significantly higher among patients with SINV infection than in the reference population (P = 0.003, OR = 3.3; 95% CI 1.7-6.5). The DRB1*01 allele was particularly frequent among patients who at 3 years post infection experienced joint manifestations. The prevalence of C4B or C4A deficiency did not significantly differ between SINV-infected patients and the reference group. The frequency of rheumatoid factor at 3 years post infection was 29.5% and had increased significantly (P = 0.02) during the 3-year period. In addition, antinuclear and anti-mitochondrial antibodies were present in serum 3 years post infection with frequencies of 15.9% and 6.8%, respectively. Conclusion: Ourdata show that symptomatic SINV infection is associated with the HLA system and that autoantibody titers are elevated in patients 3 years post infection. These findings indicate that SINV-induced arthritis shares features with autoimmune diseases.
Temperature Measurement and Accuracy with Thermo Sensitive Liquid Crystal (2005)

Recently, an electronic device is miniaturizing. simultaneously the object of temperature measurement became smaller, and more complex. The measurement of a minute area is difficult of the conventional temperature measuring method. It is already known that the temperature measuring method by thermo sensitive liquid crystal is effective in measurement of a thermal field. But a small field can not measure by conventional method. In this study the temperature measurement is enable by taking a picture of a smaller area by thermo sensitive liquid crystal. The object is temperature distribution of the natural convection. The temperature measurement is enable in a small area.
Local Policy Optimization for Trajectory-Centric Reinforcement Learning (2020)

The goal of this paper is to present a method for simultaneous trajectory and local stabilizing policy optimization to generate local policies for trajectory-centric model-based reinforcement learning (MBRL). This is motivated by the fact that global policy optimization for non-linear systems could be a very challenging problem both algorithmically and numerically. However, a lot of robotic manipulation tasks are trajectory-centric, and thus do not require a global model or policy. Due to inaccuracies in the learned model estimates, an open-loop trajectory optimization process mostly results in very poor performance when used on the real system. Motivated by these problems, we try to formulate the problem of trajectory optimization and local policy synthesis as a single optimization problem. It is then solved simultaneously as an instance of nonlinear programming. We provide some results for analysis as well as achieved performance of the proposed technique under some simplifying assumptions.
CFD Simulation of the Losses in an Inlet Guide Vane of a Transonic Test Turbine (2004)

In this work the flow through a pre-swirl turbine guide vane was calculated using two different flow solvers and compared with total pressure measurements in a downstream plane. The flow is transonic and strongly influenced by secondary flows. A special feature of this cascade is that the gap height at the hub is varying. Flow separation and leakage vortex flow dominate the loss generation. The flow is simulated using an in-house CFD code as well as the commercially available code FLUENT. The flow is carefully analysed and the loss generation mechanisms are presented in detail. The comparison with the measured total pressure distribution shows that the overall loss scheme is well predicted by both codes, but there are still large deficiencies in the quantitative results. The commercial code FLUENT is closer to the measurement data. Further investigations are performed to find out the differences between both codes.
3'-UTR-mediated post-transcriptional regulation of cancer metastasis (2011)

Epithelial-mesenchymal transition (EMT) and the underlying mechanisms and signaling pathways regulating such transitions have generated a lot of interest among cancer researchers. Much of this can be attributed to the apparent similarities in the molecular processes regulating embryonic EMT that can be recapitulated during tumor progression and metastasis. It appears that both embryonic and oncogenic EMT are regulated by an intricate interplay of transcriptional and post-transcriptional programs, and the recent discovery of a transcript-selective translational regulatory pathway controlling expression of EMT-associated mRNAs demonstrates the high fidelity and tight regulation associated with the process of EMT and metastatic progression. Heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) is emerging as a critical and integral modulator of TGFβ-induced EMT and subsequent tumor metastasis. Through its RNA-binding ability, hnRNP E1 binds distinct 3'-UTR structural elements present in mRNA transcripts required for EMT and translationally silences their expression. Translational silencing, mediated by hnRNP E1, occurs specifically at the translation elongation step through effects on the eukaryotic elongation factor-1 A1 (eEF1A1), and is relieved by Akt2-mediated phosphorylation. Interestingly, modulation of either the steady-state expression or the posttranscriptional modification of hnRNP E1 has a temporo-spatial effect on translational repression, tumorigenesis and cancer metastasis.
Correctness of Communications Protocols, A case Study (1993)

During the past few years, the technology for formal specification and verification of communication protocols has matured to the point where we believe that it now provides practical assistance for protocol design and validation. Several models for distributed systems in general and communication protocols in particular have been developed, and recent advances include formal models that allow reasoning about untimed systems as well as timed systems, e. g.,[AL92a, GSSL93, LV93a, LV93b]. In connection with these models a host of proof techniques have been developed for proving that one protocol implements another. One class of proof techniques is the simulation techniques (including refinement mappings, and forward and simulations) [AL91, GSSL93, Jon91, LV92, LV93a, LV93b]. In this work, we show how one approach to formal specification and verification of distributed systems - the live (timed) I/O automata of [GSSL93] - can be used to verify an important class of communication protocols-those for reliable at-most-once message delivery. Thus, the report has two main parts: first, the formal framework of [GSSL93] is presented and augmented with additional theory (including a new temporal logic). Second, we consider the verification example. The purpose of our work is to provide better understanding, documentation and proof for the reliable at-most-once message delivery protocols, and to test the adequacy of the formal framework.
BIOPHYSICAL STUDIES OF INFECTIOUS RIBONUCLEIC ACID FROM TOBACCO MOSAIC VIRUS (1959)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Complex and dynamic receptive field structure in macaque cortical area V4d (2004)

Area V4 is an important intermediate stage in the ventral shape processing pathway. Receptive field structure of cells in early areas (V1 and V2) within this pathway can be characterized by reverse correlation techniques, while shape selectivity in higher areas (TEO and TE) has mainly been characterized by response profiles to sets of complex stimuli. Can coding in V4 be understood within the same conceptual framework as that in early cortical areas? To what extent can response selectivity for complex shapes be explained by RF substructure? Here we used a novel reverse correlation technique (Livingstone et al., Neuron 30, 2001, 781ff.) to analyze RF substructure of neurons in cortical area V4d in the fixating macaque monkey. Cells (n=133) were stimulated with a sparse noise stimulus consisting of pairs of small squares of same or opposite contrast flashed at 60 Hz at random positions within the RF. Reverse correlation of spikes to the absolute and relative position of the squares allowed the construction of a temporal sequence of first and second order RF maps. This technique revealed RF substructure for more than 90% of V4 neurons with varying degrees of orientation tuning (determined in separate experiments). Significant 1st and 2nd order structure, both contrast-dependent and independent, was repeatedly observed. Some of these interaction patterns and their temporal dynamics are indicative of new coding principles beyond what has so far been reported for V1 and V2. In separate experiments on a subset of cells, complex shape selectivity was characterized by another reverse correlation technique invoking the presentation of a rapid sequence of Cartesian and non-Cartesian stimuli (Gallant et al., Science 259, 1993, 100ff.). A comparison of RF substructure with shape selectivity revealed systematic relationships between the two, but indicates the necessity for inclusion of higher order terms as well.
118 Influence of an Air Layer in a Double Layer Structure of Noise Reduction System with Piezoelectric Material (2011)

As a lightweight and low-cost noise reduction countermeasure, the author has developed a system to reduce the transmitted noise caused through panels by fixing noise insulation panels consisting of thin plates, piezoelectric materials and control circuits. In the case where an inductance circuit is used as a control circuit, a resonant circuit is made between capacitor of the piezoelectric material and the inductance circuit, and the transmitted noise reduced in range near the resonant frequency. This paper has described a way to spread the frequency range of control by double layer noise insulation panels with piezoelectric material. We clarified the influence given in the noise reduction effect of an air layer between upper and lower panels by the experiment.
European Population Substructure: Clustering of Northern and Southern Populations (2005)

Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans.Under a variety of conditions and tests, there is a consistent and reproducible distinction between ''northern'' and ''southern'' European population groups: most individual participants with southern European ancestry (Italian, Spanish, Portuguese, and Greek) have .85%membership in the ''southern'' population; and most northern, western, eastern, and central Europeans have .90% in the ''northern'' population group.Ashkenazi Jewish as well as Sephardic Jewish origin also showed .85%membership in the ''southern'' population, consistent with a later Mediterranean origin of these ethnic groups.Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies.
Conservation of Structure and Mechanism in Primary and Secondary Transporters Exemplified by SiaP, a Sialic Acid Binding Virulence Factor from Haemophilus influenzae (2006)

Extracytoplasmic solute receptors (ESRs) are important components of solute uptake systems in bacteria, having been studied extensively as parts of ATP binding cassette transporters. Herein we report the first crystal structure of an ESR protein from a functionally characterized electrochemical ion gradient dependent secondary transporter. This protein, SiaP, forms part of a tripartite ATP-independent periplasmic transporter specific for sialic acid in Haemophilus influenzae. Surprisingly, the structure reveals an overall topology similar to ATP binding cassette ESR proteins, which is not apparent from the sequence, demonstrating that primary and secondary transporters can share a common structural component. The structure of SiaP in the presence of the sialic acid analogue 2,3-didehydro-2-deoxy-N-acetylneuraminic acid reveals the ligand bound in a deep cavity with its carboxylate group forming a salt bridge with a highly conserved Arg residue. Sialic acid binding, which obeys simple bimolecular association kinetics as determined by stopped-flow fluorescence spectroscopy, is accompanied by domain closure about a hinge region and the kinking of an alpha-helix hinge component. The structure provides insight into the evolution, mechanism, and substrate specificity of ESR-dependent secondary transporters that are widespread in prokaryotes.
Helix formation by hydroxyamyl‐<scp>L</scp>‐glutaminyl residues in water and aqueous sodium dodecyl sulfate (1984)

Abstract Conformational properties of the hydroxyamyl‐ L ‐glutaminyl residue have been deduced from a CD study of two copolypeptides containing hydroxypropyl‐ L ‐glutaminyl residues. Mole fractions of hydroxyamyl‐ L ‐glutaminyl residues were 0.17 and 0.45. Zimm–Bragg statistical weights for the hydroxyamyl‐ L ‐glutaminyl residue in water are found to be similar to those determined by P.H. von Dreele, N. Lotan, V.S. Ananthan‐arayanan, R.H. andreatta, D. Poland, and H.A. Scheraga [(1971) Macromolecules 4 , 408–417] for the hydroxybutyl‐ L ‐glutaminyl residue. Sodium dodecyl sulfate has only a marginal effect on the helix‐forming tendency of hydroxyamyl‐ L ‐glutaminyl residues in water.
Generation of high-order rotational lines in hydrogen by four-wave Raman mixing in the femtosecond regime (1998)

More than 40 rotational Raman lines are generated using an 800-fs Ti:sapphire laser. The spectral region extends from the near-infrared to the far-ultraviolet with a considerably flat intensity distribution. The effects of laser polarization, pulsewidth, hydrogen pressure, and focusing conditions on the efficiencies of stimulated Raman scattering, four-wave Raman mixing, self-phase modulation, self-focusing, and harmonic generation are investigated. A white light continuum, generated by self-phase modulation, acts as a seed beam for the generation of high-order rotational lines through four-wave Raman mixing. Strong self-phase modulation, however, suppresses the generation of the Raman emission, due to a line broadening of the pump beam. Thus, optimization of experimental conditions is necessary for the efficient generation of high-order rotational lines.
Speech-centric multimodal interfaces (2004)

Benefiting from the knowledge of speech, language, and hearing, a new technology has arisen to serve the users with complex information systems. This technology aims for a natural communication environment, capturing the attributes that humans favor in face-to-face exchange. Conversational interaction bears a central burden, with visual and manual signaling simultaneously supplementing the communication process. In addition to instrumenting the sensors for each mode, the interface must incorporate the context-aware algorithms in fusing and interpreting the multiple sensory channels. The ultimate objective is a reliable estimate of the user's intent, from which actionable responses can be made. The current research therefore addresses the multi-modal interfaces that can transcend from the limitations of the mouse and the keyboard. This report indicates the early status of the multimodal interfaces and identifies the emerging opportunities for enhanced usability and naturalness. It concludes by advocating the focused research on a frontier issue - the formulation of a quantitative language framework for multimodal communication.
Quasi-seeded growth, phase transformation, and size tuning of multifunctional hexagonal NaLnF<sub>4</sub>(Ln = Y, Gd, Yb) nanocrystalsvia in situcation-exchange reaction (2011)

In situ cation exchange between alkali ions in ternary alkali lanthanide (Ln3+) fluoride on the nanoscale is reported. Experimental results reveal that the differences in the solubility constants and thermodynamic stability of the reactants and products affect the irreversible cation exchange between potassium and sodium, resulting in the phase transformation of cubic KLnF4 to hexagonal NaLnF4. The unusual cation-exchange reaction can be used as an efficient tool to produce seed nuclei and control the nucleation and final size of hexagonal NaLnF4 nanocrystals (NCs). During the in situ cation exchange between potassium and sodium and corresponding cubic to hexagonal phase transformation, the stable hexagonal NaLnF4 particles serving as the seed nuclei play a key role in the final size of the NCs. The in situ cation exchange approach provides not only valuable insights into the growth dynamics of Ln3+ doping-induced size tuning and phase transformation in NaYF4 and alkaline-earth fluoride NCs, but also a method to prepare high-quality multifunctional NaLnF4 NCs with tunable paramagnetism and multi-color upconversion emission.
On-Line Detection System for Internal Flaws in As-Hot-Rolled Steel Strip Using Ultrasonic Probe Array (2011)

A new ultrasonic immersion test method for detecting internal flaws in a running steel strip has been developed. A transmitting probe array and a receiving probe array are arranged face-to-face on opposite sides of the strip in water, and two flaw echoes are received by the receiving probe array: (1) Flaw echo reflected first at an internal flaw and next at the surface wall of the strip; and (2) Flaw echo reflected first at the back wall of the strip and next at an internal flaw. A linear area in the strip can be tested within a cycle of ultrasonic pulse repetition by integrating the transmission of a line-focused ultrasonic beam (25 MHz in frequency) using all elements in the transmitting probe array at once with the parallel processing of signals received by the receiving probe array. An ultrasonic detection system based on this method was subsequently installed in the No. 6 pickling line at JFE Steel, Chiba District. The steel strip being tested is immersed in water by using six additional deflector rolls. The transmitting probe array and receiving probe array cover the width of the strip so that testing of the entire volume of the strip is realized. It is confirmed that inclusions with a minimum volume of 5×10−5 mm3 can be detected at a signal-to-noise ratio in the range of 9–10 dB. The detection results are rapidly fed back to the steelmaking process to improve steel cleanliness. As a result, steel coils have maintained a high level of internal cleanliness with a dramatic reduction in defects found during the users’ manufacturing process.
Serial crystallography: use of a micro-jet for diffraction of protein nano-crystals or molecules (2008)

Microsymposiaagents against Gram-positive pathogens.Here we report new binding and structural studies of FapR from Staphilococcus aureus in complex with both its DNA operator and effector molecules, providing important hints to understand the mode of action of this conserved bacterial repressor.
A simple sensitive X-band superheterodyne spectrometer for electron spin resonance measurements (1966)

A single klystron superheterodyne X-band electron spin resonance spectrometer was constructed for sensitive measurements in a wide power region, 0.4 μw-4 mw. A 30 Mc/s modulation system was used to provide both the local oscillator power and to phase-lock the klystron frequency to the sample cavity.
Asymmetric hydrosiliylation of ketones, catalyzed by rhodium complexes containing chiral chelate ligands. Crystal and molecular structure of (bicyclo[2.2.1]hepta-2,5-diene)[(S)-N,N-dimethyl-1-[o-(diphenylarsino)phenyl]ethylamine]rhodium(I) perchlorate (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric hydrosiliylation of ketones, catalyzed by rhodium complexes containing chiral chelate ligands. Crystal and molecular structure of (bicyclo[2.2.1]hepta-2,5-diene)[(S)-N,N-dimethyl-1-[o-(diphenylarsino)phenyl]ethylamine]rhodium(I) perchlorateNicholas C. Payne and Douglas W. StephanCite this: Inorg. Chem. 1982, 21, 1, 182–188Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ic00131a034https://doi.org/10.1021/ic00131a034research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Détection et caractérisation des tourbillons de sillage des avions par Lidar Doppler (2016)

\n\t\t\t\tDans un contexte où le trafic aérien s'accroît chaque jour, l'optimisation des débits en termes de décollage et d'atterrissage est devenue un enjeu majeur pour les aéroports à forte affluence. Ces débits sont principalement limités par la présence de tourbillons de sillage communément appelés wake vortex. Ceux-ci sont formés après le passage d'un avion et représentent un danger potentiel pour l'avion suivant. Afin d'éviter les accidents, les organisations de sûreté de la navigation aérienne ont défini des distances de sécurité à respecter entre décollages ou atterrissages successifs. Ces distances prennent en compte la catégorie de poids des deux appareils en considérant des situations pirecas. De nombreuses études ont été menées pour permettre une meilleure compréhension de ces tourbillons et ont permis de constater que leur comportement varie en fonction des conditions atmosphériques, en particulier en fonction du vent et de la turbulence atmosphérique. Afin d’étudier la dynamique de la masse d’air et l’évolution de ces phénomènes, on utilise depuis une dizaine d’années le Lidar (light detection and ranging). Le Lidar pulsé est devenu l’instrument de référence pour la mesure à distance des tourbillons de sillage (positions et puissance).\n\t\t\t