gebhart/patrepeval huggingface dataset:
Fatty acid binding and conformational stability of mutants of human muscle fatty acid-binding protein (1996)

Human muscle fatty acid-binding protein (M-FABP) is a 15 kDa cytosolic protein which may be involved in fatty acid transfer and modulation of non-esterified fatty acid concentration in heart, skeletal muscle, kidney and many other tissues. Crystallographic studies have suggested the importance of the amino acids Thr-40, Arg-106, Arg-126 and Tyr-128 for the hydrogen bonding network of the fatty acid carboxylate group. Two phenylalanines at 16 and 57 are positioned to interact with the acyl chain of the fatty acid. We prepared 13 mutant proteins by site-directed mutagenesis and tested them for fatty acid binding and stability. Substitution of amino acids Phe-16, Arg-106 or Arg-126 created proteins which showed a large decrease in or complete loss of oleic acid binding. Substitution of Phe-57 by Ser or Val and of Tyr-128 by Phe had no great effect. The stability of the mutant proteins was tested by denaturation studies on the basis of fatty acid binding or tryptophan fluorescence and compared with that of the wild-type M-FABP. There was no direct relationship between fatty acid-binding activity and stability. Less stable mutants (F57S and Y128F) did not show a marked change in fatty acid-binding activity. Substitution of Arg-126 by Gln or Arg-106 by Thr eliminated binding activity, but the former mutant protein showed wild-type stability, in contrast to the latter. The results are in agreement with crystallographic data.
A Retrospective Study of Laparoscopic Versus Open Cholecystectomy. (1993)

最近2年2か月間の胆襲摘出術症例120例を腹腔鏡下胆菱摘出術が施行された78例 (LC群) と開腹下胆襲摘出術が施行された42例 (OC群) の2群に分け, 術前所見, 手術成績および手術前後の検査値の変動などについて比較検討した. 術前所見では胆襲造影陰性例, 急性胆嚢炎および開腹術の既往は両群間に差はなく, 併存疾患の合併率はLC群で多かった. 手術成績では, LC群ではOC群に比べ手術時間の延長がみられるものの出血量は有意に減少した. またLC群では発熱の頻度および程度が軽減し, 術後白血球数, CRPの増多および術後疼痛がより軽度で, 経口開始日数および入院日数の短縮もみられた. 術後の肝あるいは腎機能におよばす影響も少なかった. これらのことから, LCでは手術侵襲はOCに比べより軽微であると考えられ, また, 手術時間は延長する傾向があるものの重篤な合併症もみられず, 胆襲輸出術の標準術式と考えてよいと思われた.
Refractoriness to platelet transfusion following partial hepatectomy for hepatocellular carcinoma: report of two cases. (2003)

Refractoriness to platelet transfusion indicates a condition in which an expected increase in platelet count is not attained after platelet transfusion. We report herein two cases of refractoriness to platelet transfusion that were caused by the presence of antibodies against the human leukocyte antigen following partial hepatectomy for hepatocellular carcinoma. Due to low postoperative platelet counts in the first case, the patient was transfused with 75 units of platelet concentrate for 3 days after surgery, but was unable to gain a significant increase in the platelet count because of platelet transfusion refractoriness due to anti-human leukocyte antigen antibodies. This case was not complicated and had a favorable clinical course. Despite being transfused with 60 units of platelet concentrate during the 2 days after surgery, the patient's platelet count in the second case did not increase because of the presence of anti-human leukocyte antigen antibodies. Bleeding from the cut surface of the liver into the intraperitoneal cavity was found on the second postoperative day because of a decrease in platelet count. On postoperative day 5, disseminated intravascular coagulation occurred. Perioperative refractoriness to platelet transfusion is an intractable complication since no efficient treatment is available. Preoperative examinations for anti-platelet antibodies should be performed in patients undergoing hepatectomy for hepatocellular carcinoma. This is especially true in cases of decreased platelet counts due to preceding liver cirrhosis and when the prediction for postoperative platelet transfusions is necessary.
Humoral Response Suppression Observed with CD23 Transgenics (1999)

CD23, also known as the low affinity IgE receptor (FcepsilonRII), has been hypothesized to have a role in IgE regulation. A new CD23 transgenic mouse was generated using the MHC class I promoter and IgH enhancer to further test the hypothesis that CD23 plays a role in the down-regulation of IgE. Study of three founder lines by FACS showed overexpression to varying extents on both B and T lymphocytes. No alterations in lymphocyte populations was observed. All three founder lines exhibited strong suppression of IgE in response to DNP-keyhole limpet hemocyanin/alum and Nippostrongylus brasiliensis infection compared with that in parental or littermate controls. The founder line exhibiting the highest level of suppression also was less susceptible to Ag-induced systemic anaphylactic shock. Overall, the data support the concept that enhancing CD23 levels can be used to suppress IgE-mediated disease. The mechanism involves decreased IgE synthesis, because the serum half-life of IgE was not altered in transgenics, and enzyme-linked immunospot analysis demonstrated lower IgE-producing cells stimulated by injection of anti-IgD. Transgenics also exhibited significantly decreased IgG1 responses and exhibited lower levels of all Ig isotypes, although this was more variable in different founder lines.
Tuning the Selectivity of Monoamine Transporter Inhibitors by the Stereochemistry of the Nitrogen Lone Pair (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTuning the Selectivity of Monoamine Transporter Inhibitors by the Stereochemistry of the Nitrogen Lone PairMiles P. Smith, Kenneth M. Johnson, Mei Zhang, Judith L. Flippen-Anderson, and Alan P. KozikowskiView Author Information Institute for Cognitive and Computational Sciences Georgetown University Medical Center Washington, D.C. 20007-2197 Department of Pharmacology and Toxicology University of Texas Medical Branch Galveston, Texas 77555-1031 Laboratory for the Structure of Matter Naval Research Laboratory, Washington, D.C. 20375 Cite this: J. Am. Chem. Soc. 1998, 120, 35, 9072–9073Publication Date (Web):August 22, 1998Publication History Received27 April 1998Published online22 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/ja981423shttps://doi.org/10.1021/ja981423srapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views327Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (4)»Supporting Information Supporting Information SUBJECTS:Amines,Inhibition,Nitrogen,Pharmaceuticals,Selectivity Get e-Alerts
Autonomously creating a hierarchy of intelligent agents using clustering in a multi-agent system (2008)

In this paper, we present an approach to automatically create a hierarchy of agents. The hierarchy clusters similar agents and, thereby, optimizes locality. The clustering improves task efficiency ...
High-solids black liquor firing in pulp and paper industry kraft recovery boilers: Phase 1 -- Final report. Volume 2: Project technical results (1995)

This project is a multiple-phase effort to develop technologies to improve high-solids black liquor firing in pulp mill recovery boilers. The principal means to this end is to construct and operate a pilot-scale recovery furnace simulator (RFS) in which these technologies can be tested. The Phase 1 objectives are to prepare a preliminary design for the RFS, delineate a project concept for evaluating candidate technologies, establish industrial partners, and report the results. Phase 1 addressed the objectives with seven tasks: Develop a preliminary design of the RFS; estimate the detailed design and construction costs of the RFS and the balance of the project; identify interested parties in the paper industry and key suppliers; plan the Phase 2 and Phase 3 tests to characterize the RFS; evaluate the economic justification for high-solids firing deployment in the industry; evaluate high-solids black liquor property data to support the RFS design; manage the project and reporting results, which included planning the future program direction.
Transfer of Allergen-Specific IgE-Mediated Hypersensitivity with Allogeneic Bone Marrow Transplantation (1988)

We investigated whether allergen-specific IgE-mediated hypersensitivity is transferred by bone marrow transplantation. Twelve patients, 14 to 47 years of age, undergoing allogeneic bone marrow transplantation for the treatment of hematologic cancer were selected, along with their donors, by a screening questionnaire for a history of atopy in the donor. We evaluated these donor-recipient pairs before transplantation and at several points afterward for immediate skin-test reactivity to 17 allergens. For allergens for which pretransplantation skin tests had been positive in the donors and negative in the recipients, 20 of 46 post-transplantation skin tests were positive in 8 of the 11 recipients who survived for more than one year after transplantation. For allergens for which both donors and recipients had had negative skin tests before transplantation, only 6 of 256 tests (2.3 percent) were positive in the recipients after transplantation. Long-term transfer of donor-derived mite-specific IgE was demonstrated by radioallergosorbent testing in two recipients. Seven recipients either acquired or had an exacerbation of allergic rhinitis, and two recipients without a history of asthma had asthma one year after transplantation. We conclude that allergen-specific IgE-mediated hypersensitivity is adoptively transferred by bone marrow transplantation from donor to recipient by B cells with allergen-specific memory.
The Gyricon rotating ball display (1999)

Abstract— The Gyricon display consists of hemispherical black and white (bichromal) balls contained in individual liquid‐filled cavities and disposed to orient in an electrical field. This bistable reflective light display currently has a diffuse reflectance of more than 18% and a contrast ratio of more than 6:1. The viewing angle approaches that of paper. A new method of fabricating the bichromal balls has enabled practical realization of large‐area high‐quality displays.
Stable vortex-soliton tori with multiple nested phase singularities in dissipative media (2012)

We show the existence of stable two- and three-dimensional vortex solitons carrying multiple, spatially separated, single-charge topological dislocations nested in a common vortex-ring core. Such nonlinear states are supported by elliptical gain landscapes in focusing nonlinear media with two-photon absorption. The separation between the phase dislocations is dictated mostly by the geometry of the gain landscape, and it only slightly changes upon variation of the gain or absorption strength.
All-optical add/drop (2002)

In this work we have demonstrated that a single pulse generator, which cascaded two LiNbO3 modulators serially, may be used to demultiplex or drop a 10 Gb/s channel from a 40 Gb/s transmission system. The parts in the experiment are all commercially available, and this technique is scalable to higher speed transmission system.
Effect of sludge age on methanogenic and glycogen accumulating organisms in an aerobic granular sludge process fed with methanol and acetate (2015)

The influence of sludge age on granular sludge formation and microbial population dynamics in a methanol- and acetate-fed aerobic granular sludge system operated at 35°C was investigated. During anaerobic feeding of the reactor, methanol was initially converted to methane by methylotrophic methanogens. These methanogens were able to withstand the relatively long aeration periods. Lowering the anaerobic solid retention time (SRT) from 17 to 8 days enabled selective removal of the methanogens and prevented unwanted methane formation. In absence of methanogens, methanol was converted aerobically, while granule formation remained stable. At high SRT values (51 days), γ-Proteobacteria were responsible for acetate removal through anaerobic uptake and subsequent aerobic growth on storage polymers formed [so called metabolism of glycogen-accumulating organisms (GAO)]. When lowering the SRT (24 days), Defluviicoccus-related organisms (cluster II) belonging to the α-Proteobacteria outcompeted acetate consuming γ-Proteobacteria at 35°C. DNA from the Defluviicoccus-related organisms in cluster II was not extracted by the standard DNA extraction method but with liquid nitrogen, which showed to be more effective. Remarkably, the two GAO types of organisms grew separately in two clearly different types of granules. This work further highlights the potential of aerobic granular sludge systems to effectively influence the microbial communities through sludge age control in order to optimize the wastewater treatment processes.
Optimization with missing data (2006)

Engineering optimization relies routinely on deterministic computer based design evaluations, typically comprising geometry creation, mesh generation and numerical simulation. Simple optimization routines tend to stall and require user intervention if a failure occurs at any of these stages. This motivated us to develop an optimization strategy based on surrogate modelling, which penalizes the likely failure regions of the design space without prior knowledge of their locations. A Gaussian process based design improvement expectation measure guides the search towards the feasible global optimum.
Abstract 14678: Transcription Factor-Driven Conversion of Quiescent Cardiomyocytes to Pacemaker Cells (2012)

Hee Cheol Cho, 2012 Finalist and Presenting Author
Anorectal functional testing: review of collective experience (2002)

Anorectal manometry includes a number of specific tests that are helpful in the diagnostic assessment of patients with fecal incontinence and constipation; their purpose is to delineate the pathophysiological mechanism for these symptoms. Some of these tests may also provide helpful information in the assessment of patients with rectal pain or diarrhea, but their sensitivity and specificity are less well established for these symptoms. Tests for which there is consensus regarding their clinical utility include 1) resting anal canal pressure, 2) anal canal squeeze pressure (peak pressure and duration), 3) the rectoanal inhibitory reflex elicited by balloon distension of the rectum, 4) anal canal pressure in response to a cough, 5) anal canal pressure in response to defecatory maneuvers, 6) simulated defecation by means of balloon or radiopaque contrast, 7) compliance of the rectum in response to balloon distension, and 8) sensory thresholds in response to balloon distension. Anal endosonography and pelvic floor electromyography from intra-anal plate electrodes are nonmanometric tests that are also specifically useful in the evaluation of constipation and fecal incontinence. The clinical utility of all anorectal manometric tests is limited by the relative absence of 1) standardization of test protocols and 2) normative data from a large number of healthy individuals. The interpretation of these diagnostic tests is also complicated by the fact that patients are able to compensate for deficits in specific physiological mechanisms maintaining continence and defecation by utilizing other biological and behavioral mechanisms.
Minimization of Pt content in Pt-CeO<sub>2</sub> composite anode (2008)

Direct methanol fuel cells (DMFCs) are attracting much attention as clean and efficient power sources.
Experiments on stability of Nb<sub>3</sub>Sn ribbons (1972)

The major instability problem in Nb3Sn ribbon superconductors is known to be due to flux jumps caused by magnetic field components perpendicular to the face of the ribbons (H$_\perp$). Likewise, techniques which are intended to prevent this instability are also well known and include (1) reducing the width of the ribbon, (2) using low current rated material in regions of large H$_\perp$), (3) paralleling the ribbon with good electrical conducting material, and (4) providing as much cooling as possible. The decision, in 1968, to employ Nb3Sn ribbon in IMP, a large plasma physics research facility, was made without full knowledge of how bad the instability really was. While difficult force problems and machining and assembly problems were being solved, experiments were performed to determine the best way to reach the IMP quadrupole design point. The stability question was answered by performing experiments with relatively large test coils called ''cusp coils'' which showed that stabilization could be achieved by cowinding 0.006 in. aluminum ribbon along with the Nb3Sn ribbon
ChemInform Abstract: Cycloaddition Reactions of Furan Derivatives with Trifluoroethene. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<i>Legionella pneumophila</i>Contains a Type II General Secretion Pathway Required for Growth in Amoebae as Well as for Secretion of the Msp Protease (1999)

We report the identification of a set of Legionella pneumophila genes that encode products with homology to proteins of the type II general secretion pathway of gram-negative bacteria. A strain containing a deletion-substitution mutation of two of these genes was unable to secrete the Msp protease. This strain was unable to multiply within the free-living amoeba Acanthamoeba castellanii yet was able to kill HL-60-derived macrophages. Because Msp is not required for growth in amoebae, other proteins which are important for growth in amoebae are likely secreted by this pathway.
Bayesian Image Super-resolution, Continued (2007)

This paper develops a multi-frame image super-resolution approach from a Bayesian view-point by marginalizing over the unknown registration parameters relating the set of input low-resolution views. In Tipping and Bishop's Bayesian image super-resolution approach [16], the marginalization was over the superresolution image, necessitating the use of an unfavorable image prior. By integrating over the registration parameters rather than the high-resolution image, our method allows for more realistic prior distributions, and also reduces the dimension of the integral considerably, removing the main computational bottleneck of the other algorithm. In addition to the motion model used by Tipping and Bishop, illumination components are introduced into the generative model, allowing us to handle changes in lighting as well as motion. We show results on real and synthetic datasets to illustrate the efficacy of this approach.
Simultaneous pulse wave and flow estimation at high-framerate using plane wave and transverse oscillation on carotid phantom (2017)

Pulse wave velocity and blood flow velocity are two different physiological parameters which are generally assessed using two different ultrasound sequences and processing techniques. This can be explained by the difference in term of signal intensity between the tissue and blood (approx. 40 dB). On one side, blood velocity can be estimated using Doppler, speckle tracking or transverse oscillation techniques... On the other side the arterial wall motion can be obtained using block matching, differential methods or adapted transverse oscillations. In order to better evaluate and understand blood-wall interaction an imaging technique able to provide simultaneously both information from the same sequence would be highly relevant. Accordingly, our objective is to extract pulse wave velocity and flow all at once.
Non-Aqueous Battery Systems (1996)

Lithium and sodium are light and highly electronegative elements which form the basis of anodes for high-energy-density battery systems. Their high chemical reactivity requires the use of ionic conductors based on non-aqueous solvents, polymers, solid electrolytes or fused salts. An associated range of cathode materials enables cells to be fabricated with open-circuit voltages from 1.5 to 4.0 V. Practical non-aqueous batteries have energies extending from 100 m Wh primary button cells used to power electric watches to 20 kWh secondary batteries being developed for vehicle traction. Power output also varies dramatically with application, ranging from a cardiac pacemaker power source operating at 25-100 $\mu $W for up to 10 years, to a military lithium thermal battery delivering all of its energy in a 1 s pulse, with a specific power of 5 kW kg$^{-1}$. This wide range of applications demands diverse electrical characteristics which may include low self-discharge, extensive cyclability, prolonged shelf-life, etc., and which in turn call for many different types of battery design and materials. This paper surveys the battery chemistry, materials and design of lithium-based primary and reserve cells and of lithium and sodium-based rechargeable batteries.
Rheological Considerations in Coextrusion (1985)

Successful coextrusion depends to a large extent on the rheological properties of the polymers being coextruded. Several important articles have appeared in the litera ture in the past few years on the rheology of coextrusion. These analyses provide invaluable help in understanding how the rheological properties of the polymers in volved affect the coextrusion process and the product produced.
ChemInform Abstract: Silyl Cuprate Couplings: Less Silicon, Accelerated Yet Catalytic in Copper. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thiacalix[4] Tube: Synthesis, X‐Ray Crystal Structure and Preliminary Binding Studies. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Occult gastrointestinal carcinoma causing metastatic clostridial soft-tissue infection (1988)

The association between nontraumatic, metastatic, clostridial soft-tissue infection and malignancy is well recognized, particularly when Clostridium septicum is involved. This report presents two patients with nontraumatic, metastatic, soft-tissue infection due to C. septicum and reviews the English medical literature. Eighty-four percent of the reported patients were found to have colon carcinoma, which was postulated to be the portal of entry. Prognosis is poor, but early recognition and antimicrobial therapy with prompt and aggressive surgical intervention, both for the soft-tissue infection and the abdominal process, may lower the high mortality.