gebhart/patrepeval huggingface dataset:
Slow slip events and strain accumulation in the Guerrero gap, Mexico (2012)

Global positioning system (GPS) time series in Guerrero (Mexico) reveal the existence of large slow slip events (SSEs) at the boundary between the Cocos and North American plates. In this study, we examined the last three SSEs that occurred in 2001/2002, 2006 and 2009/2010, and their impact on the strain accumulation along the Guerrero subduction margin. GPS displacements were inverted to retrieve the slip distribution during each SSE and the inter‐SSE coupling of the subduction interface. The three analyzed SSEs have equivalent moment magnitudes of between 7.50 and 7.65, their lateral extents are variable, and they all show significant slip in the Guerrero seismic gap. During the inter‐SSE epochs, the interplate coupling is high in the area where slow slip subsequently occurs. In the Guerrero gap, the shallow portion of the plate interface from the trench to the coast is weakly coupled. The average slip deficit accumulated in the Guerrero gap over a period of 12 years, which corresponds to three cycles of SSE, is only 1/4 of the slip deficit accumulated on both sides of the gap. Moreover, the regions of large slip deficit coincide with the rupture areas of recent large earthquakes. We conclude that the SSEs in the Guerrero gap release a significant part of the strain accumulated during the inter‐SSE period. If large subduction thrust earthquakes occur in the Guerrero gap, their recurrence time is probably increased compared to adjacent regions.
Effective initial therapy of advanced breast cancer with fluorouracil and high-dose, continuous infusion calcium leucovorin. (1992)

FU plus LV is an active first-line regimen with antitumor efficacy comparable to that of the anthracyclines, which warrants further exploration in combination with other agents active in advanced breast cancer. FU plus LV in this schedule is also an excellent alternative for patients with medical contraindications to more intensive combination chemotherapy regimens.
Remarks on input to state stabilization (2004)

We announce a new construction of a stabilizing feedback law for nonlinear globally asymptotically controllable (GAC) systems. Given a control affine GAC system, our feedback renders the closed loop system input to state stable with respect to actuator errors and small observation noise. We also announce a variant of our result for fully nonlinear GAC systems.
Quantifying Dimensional Accuracy of a Mask Projection Micro Stereolithography System (2004)

Mask Projection Microstereolithography is capable for fabricating true three-dimensional microparts and hence, holds promise as a potential micro-fabrication process for micro-machine components. In this paper, the Mask Projection Micro-Stereolithography (MPµSLA) system developed at the Rapid Prototyping and Manufacturing Institute at Georgia Institute of Technology is presented. The dimensional accuracy of the system is improved by reducing its process planning errors. To this effect, the MPµSLA process is mathematically modeled. In this paper, the irradiance received by the resin surface is modeled as a function of the imaging system parameters and the pattern displayed on the dynamic mask. The resin used in the system is characterized to experimentally determine its working curve. This work enables us to compute the dimensions of a single layer cured using our system. The analytical model is validated by curing test layers on the system. The model computes layer dimensions within 5% error.
A novel proline-rich protein, EspF, is secreted from enteropathogenic Escherichia coli via the type III export pathway (1998)

Enteropathogenic Escherichia coli (EPEC) cause a characteristic attaching and effacing (A/E) lesion in intestinal epithelial cells that is associated with the expression and export of specific bacterial proteins via a type III secretion pathway. These effector proteins and components of the type III export apparatus are encoded on a pathogenicity island known as the locus of enterocyte effacement (LEE). In this study, we describe a proline-rich protein, EspF, encoded by the LEE that is secreted by the EPEC type III secretion apparatus. Whereas an espF deletion mutant does not synthesize or secrete EspF, surprisingly it retains the ability to induce host signaling events, perform A/E activities, and invade host epithelial cells. Although these results do not indicate on obvious role for EspF in the formation of A/E lesions nor in the invasion of epithelial cells, they do not preclude a role played by EspF in other aspects of EPEC pathogenesis.
Nonlinear effects in left-handed metamaterials (2004)

We analyze nonlinear properties of microstructured materials with negative refraction, the so-called left-handed metamaterials. We demonstrate that the hysteresis-type dependence of the magnetic permeability on the field intensity allows changing the material properties from left- to right-handed and back. We predict also that nonlinear left-handed metamaterials can support both TE- and TM-polarized self-trapped localized beams, spatial electromagnetic solitons. Such solitons appear as single- and multi-hump beams, being either symmetric or antisymmetric, and they can exist due to the hysteresis-type magnetic nonlinearity and the effective domains of negative magnetic permeability.
Using Scalp Electrical Biosignals to Control an Object by Concentration\n and Relaxation Tasks: Design and Evaluation (2011)

In this paper we explore the use of electrical biosignals measured on scalp\nand corresponding to mental relaxation and concentration tasks in order to\ncontrol an object in a video game. To evaluate the requirements of such a\nsystem in terms of sensors and signal processing we compare two designs. The\nfirst one uses only one scalp electroencephalographic (EEG) electrode and the\npower in the alpha frequency band. The second one uses sixteen scalp EEG\nelectrodes and machine learning methods. The role of muscular activity is also\nevaluated using five electrodes positioned on the face and the neck. Results\nshow that the first design enabled 70% of the participants to successfully\ncontrol the game, whereas 100% of the participants managed to do it with the\nsecond design based on machine learning. Subjective questionnaires confirm\nthese results: users globally felt to have control in both designs, with an\nincreased feeling of control in the second one. Offline analysis of face and\nneck muscle activity shows that this activity could also be used to distinguish\nbetween relaxation and concentration tasks. Results suggest that the\ncombination of muscular and brain activity could improve performance of this\nkind of system. They also suggest that muscular activity has probably been\nrecorded by EEG electrodes.\n
Tunica Albuginea Tissue Analysis After Electromotive Drug Administration (2003)

Electromotive drug administration is a safe and noninvasive treatment modality. Verapamil was detected in 71.5% of tunica albuginea specimens after electromotive drug administration with a wide range of verapamil levels. To our knowledge whether these levels affect change in Peyronie's disease plaque, resulting in improvement in penile deformity, is unknown and requires further placebo controlled trials.
Evaluación De Catalizadores Orgánicos y Mixtos Orgánicos/Inorgánico en el Proceso de Transesterificación para la Obtención de Biodiesel (2010)

LA obtención de biodiesel a partir de la transesterificación con alcoholes constituye uno de los desafíos más interesantes de la Química Orgánica. La esterificación por tratarse de una reacción gobernada por el equilibrio resulta en un sistema complejo, cuyas variables operativas son materia de estudio. De los procesos clásicos la catálisis ácida brinda las mejores perspectivas. En este trabajo se explora la obtención de biodiesel a partir de etanol 96% y aceite de girasol utilizando un catalizador derivado del ácido sulfónico. Se utiliza ácido bencensulfónico puro y soportado en diferentes proporciones sobre montmorillonita (MMT)intercambiada con cromo. El seguimiento de la reacción implica técnicas de separación clásicas para laboratorio orgánico tales como, cromatografía en papel, índice de refracción y destilación. En las etapas de análisis se discuten las mejores condiciones de separación y el empleo de índice de refracción como técnica rápida para el seguimiento del grado de conversión del proceso.
A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues (2011)

Our findings demonstrate the use of the genetic sensor as a tool in first-line evaluation of new vitamin D3 analogues and pave the way for new types of drug delivery studies in sensor-transgenic animals.
Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound (2007)

The combination of ultrasound and semi-variogram analyses allows quantitative assessment of dynamic changes in the structure of human connective tissue in vivo.
ROTATIONAL SPECTRUM OF THE METHANE-OZONE VAN DER WAALS COMPLEX USING FT-MICROWAVE SPECTROSCOPY (1995)

$^{1}$ Meunter, J. S., DeLeon, R. L., Yokozeki, A; Faraday Discuss, Chem. Soc., 1982, 73, 63-70 ${\ast}$ This frequency was obtained via new measured made on the $ArO_{3}$ complex at NIST
Opportunities for Machine Learning in District Heating (2021)

The district heating (DH) industry is facing an important transformation towards more efficient networks that utilise significantly lower water temperatures to distribute the heat. This change requires taking advantage of new technologies, and Machine Learning (ML) is a popular direction. In the last decade, we have witnessed an extreme growth in the number of published research papers that focus on applying ML techniques to the DH domain. However, based on our experience in the field, and an extensive review of the state-of-the-art, we perceive a mismatch between the most popular research directions, such as forecasting, and the challenges faced by the DH industry. In this work, we present our findings, explain and demonstrate the key gaps between the two communities and suggest a road-map ahead towards increasing the impact of ML research in the DH industry.
Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight (2010)

Maternal nutritional status, e.g. body weight and composition, is associated with fetal growth. It has been suggested that the insulin-like growth factor (IGF) system may be a mediator of this relationship. In twenty-three healthy Swedish women, we studied (1) the relationships before and during pregnancy between maternal serum concentrations of IGF-I and IGF binding protein-1 (IGFBP-1) and maternal body weight and composition; (2) interactions between serum concentrations of IGF-I (before and in early pregnancy) and maternal nutritional status in relation to infant birth weight. We found that serum IGF-I during pregnancy was positively correlated with maternal body weight (r 0.47-0.56) and fat-free body weight (r 0.61-0.65), whereas serum IGFBP-1 was negatively correlated with maternal body weight (r - 0.44 to - 0.69) and body fat (r - 0.64 to - 0.76) before and during pregnancy. Women with a lower body fat content (%) before pregnancy had greater increases in serum IGFBP-1 during pregnancy than women with a higher prepregnant body fat content (%). In addition, significant fractions of the variation in corrected infant birth weight were explained by variables related to the maternal nutritional status when these were combined with serum concentrations of IGF-I in gestational week 14 (adjusted r2 0.25-0.44, P = 0.001-0.021), but not when they were combined with such concentrations before pregnancy (adjusted r2 0.11-0.12, P = 0.105-0.121). These results suggest mechanisms by which the IGF system may be a mediator between maternal nutritional status and fetal growth.
The Mitomycin Antibiotics. Synthetic Studies. XXII. Antibacterial Structure-Activity Relationships in the Indoloquinone Series (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Mitomycin Antibiotics. Synthetic Studies. XXII. Antibacterial Structure-Activity Relationships in the Indoloquinone SeriesMartin Weiss, Gunnar Redin, George Allen, Albert Dornbush, Harry Lindsay, John Poletto, William Remers, Reta Roth, and Adolf SlobadaCite this: J. Med. Chem. 1968, 11, 4, 742–745Publication Date (Print):July 1, 1968Publication History Published online26 November 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/jm00310a602https://doi.org/10.1021/jm00310a602research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
9-cis-Retinoic Acid Inhibits Androgen Receptor Activity through Activation of Retinoid X Receptor (2005)

Although the retinoic X receptor (RXR) forms heterodimers with many members of the estrogen receptor subfamily, the interaction between RXR and the members of the glucocorticoid receptor subfamily remains unclear. Here we show that the RXR can form a heterodimer with the androgen receptor (AR) under in vitro and in vivo conditions. Functional analyses further demonstrated that the AR, in the presence or absence of androgen, can function as a repressor to suppress RXR target genes, thereby preventing the RXR binding to the RXR DNA response element. In contrast, RXR can function as a repressor to suppress AR target genes in the presence of 9-cis-retinoic acid, but unliganded RXR can function as a weak coactivator to moderately enhance AR transactivation. Together, these results not only reveal a unique interaction between members of the two nuclear receptor subfamilies, but also represent the first evidence showing a nuclear receptor (RXR) may function as either a repressor or a coactivator based on the ligand binding status.
Forensic engineering Laboratory Preparation for Litigation (1990)

As forensic experts, we can come up with many reasons why or how a given event happened or didnt happen. Good reasons are sometimes used when they seem reasonable and support the hypothesis of the expert. However, they may lead to erroneous conclusions if insufficient investigation has been done. Real reasons, on the other hand, may be far more difficult to come up with and may require much more detailed investigation and, sometimes, may completely change previously held viewpoints or opinions. It is our responsibility as forensic engineers to always seek out the real reasons in providing unbiased opinions.
The effects of polyamine biosynthesis inhibitors on growth, enzyme activities and polyamine concentrations in the mycorrhizal fungus <i>Laccaria proxima</i> (1994)

SUMMARY Difluoromethylarginine (DFMA) and difluoromethylornithine (DFMO) are inhibitors of the polyamine biosynthetic enzymes arginine decarboxylase (ADC) and ornithine decarboxylese (ODC), respectively, DFMO is a potential fungicide acting on fungal ODC. This report examines the effects of DFMA and DFMO on polyamine concentrations and metabolism, and on the activities of enzymes of polyamine biosynthesis and breakdown in the mycorrhizal fungus Laccaria proxima. Data indicate that L. proxima possesses both ADC and ODC activities: DFMA depleted putrescine and did not inhibit ODC activity; incubation of mycelium with a [U‐ 14 C]arginine substrate led to [ 14 C]putrescine formation DFMA completely inhibited the formation of polyamines from [U‐ 14 C]arginine DFMO inhibited bound biosynthetic enzyme activity and the formation of putrescine from [U‐ 14 C]ornithine. Therefore, L. proxima may not be susceptible to fungicidal DFMO application.
Muscle cramps (1990)

• Painful involuntary skeletal muscle contractions, or cramps, are common patient complaints and may be classified as examples of true cramp, tetany, contracture, or dystonia. The pathophysiologic and clinical features of each of these diagnoses are described. The approach to the patient with cramps should emphasize the history, physical examination, and, if the diagnosis is unclear, minimal routine laboratory data. Although many therapies have been proposed for ordinary cramps, the best evidence supports stretching exercises and quinine. Areas for future study of this common symptom are proposed. (<i>Arch Intern Med</i>. 1990;150:511-518)
PERITONEAL IRRIGATION FOR UREMIA FOLLOWING INCOMPATIBLE BLOOD TRANSFUSION (1947)

PERITONEAL irrigation as a means of treating a patient with uremia resulting from acute renal damage following sulfathiazole therapy has been reported by Frank, Seligman and Fine.<sup>1</sup>These same workers had previously observed the results of this technic on animals.<sup>2</sup>Recently we utilized this method of peritoneal irrigation on a patient with uremia resulting from an incompatible blood transfusion. The procedure was effective and directly associated with improvement and subsequent recovery of the patient. The patient was not expected to survive, since grave sequelae of uremia existed. Moreover, certain complications related to the peritoneal irrigation were encountered. A report of the case therefore seems warranted. <h3>REPORT OF A CASE</h3> A white woman aged 36 years entered the hospital for a pelvic operation. A transfusion of whole blood was ordered prior to operation as a corrective measure for a moderate degree of anemia (red blood cell count 3,600,000 per
VLF remote sensing of the auroral electrojet (1996)

We investigate a new potential technique to determine the position of the auroral electrojet from ground‐based VLF amplitude and phase measurements. The chief advantage of this technique over conventional ground magnetometer measurements is that it can provide data on a continental scale with a small number of receiving stations and with a minimum of data processing. At the edge of the auroral zone, where the electrojet current system flows, high‐energy ( E > 300 keV) precipitating electrons cause local electron density enhancements in the ionosphere which cause phase and amplitude perturbations in VLF waves propagating in the Earth‐ionosphere waveguide. Continuous measurements of the amplitude and phase of signals from the Omega North Dakota VLF transmitter were made in Nome, Alaska. Using a two‐dimensional model of VLF propagation which accounts for ionospheric disturbances caused by the electron precipitation associated with the electrojet, the amplitude and phase signatures of electrojet incursion across each propagation path were predicted. Seventeen nights of simultaneous VLF amplitude and phase data and ground magnetometer data were examined and catalogued based on the degree of temporal correlation between the two data sets and the degree to which the VLF events matched the propagation simulations. Of the nights exhibiting activity, more than 60% exhibited excellent correlation between the magnetometer and VLF events, and the majority of these showed good agreement with the model results. An additional estimate of the electrojet position was provided for one of the studied nights by field‐aligned current measurements from the Freja satellite. A comparison of these independent means of determining the electrojet position shows that they are in good agreement for the night examined.
Antitumoral effect of gemcitabine metronomic schedule in a xenograft pancreatic model (2006)

12031 Background: Human tumor xenografts in mice can be remarkably predictive of response in humans to cytotoxic chemotherapeutic drugs. Tumor endothelial cells are sensitive to the action of conventional cytotoxic drugs when they are regularly administrated at low doses. This concept, known as metronomic chemotherapy, has been demonstrated in preclinical studies using transplanted tumor models. We aim to investigate the potential anti-tumoral activity of Gemcitabine (G) when administered in a low-dose schedule in an ortothopic implantation model of human pancreatic carcinomas. Methods: Standard gemcitabine schedule: NP18 tumor orthotopically implanted nude mices were randomly distributed to experimental (n = 13, G100 mg/kg intraperitoneally on days 0, 3, 6 and 9 post-implantation) and control group (n = 13, saline). Animal were sacrificed after 4 weeks and we compared weigths (grams) and volume (cm3) of tumors betwen the two groups by the Mann-Whitney U test. Metronomic schedule: After a toxicological study an optimal metronomic dose of 1 mg G /kg per day was chosen. Thirty xenografted mices were randomly distributed to experimental group (n = 15, intraperitoneal G1 mg/kg) and control group (n = 15, saline) and treated for 30 days. Animal were analysed as described before. Results: Standard schedule: Tumor weight mean of treatment group was 0.01 grams ± 0.01 versus 0.54 grams ± 0.48 of the control group. Tumor volume mean in G group was 0.01 cm 3 ± 0.01 versus 0.51 cm 3 ± 0.67) in the control group.Treatment significantly inhibited NP18 tumour growth (p < 0.001). No differences in mice weight were observed between both groups. Metronomic schedule: Tumor weight mean in the treatment group was 0.04 grams ± 0.08 versus 0.53 grams ± 0.46 in control group. Tumor volume mean in G group was 011 cm 3 ± 0.19 versus 0.37 cm 3. Treatment with low-dose of G significantly inhibited NP18 tumour growth (p < 0.003). There were no differences in mice weight between the two groups. Conclusions: Our data show that G administered in a metronomic schedule is effective in inhibiting the growth of NP18 tumor orthotopically implanted in the nude mice. We now aim to study the angiogenic profile of tumors receiving the standard and metronomic schedule and to set up a new experiment to compare survival benefit in the animal model. No significant financial relationships to disclose.