gebhart/patrepeval huggingface dataset:
Estimation of Surface Parameters From MISR Data (2005)

The Multi-angle Imaging SpectroRadiometer (MISR) instrument is designed to provide global imagery at nine discrete viewing angles and four visible/near-infrared spectral bands. The MISR standard products include green Leaf Area Index (LAI) of vegetation and Fraction of Photosynthetically Active Radiation absorbed by vegetation (FPAR). These parameters are being routinely processed from MISR data at the Langley Atmospheric Sciences Data Center since October 2002. A principal objective of the MISR approach is to retrieve LAI and FPAR without requiring a static, pre-specified global biome map. Single angle retrievals require this information to constrain the results. Performance of the MISR LAI/FPAR algorithm for a limited set of data from Africa suggests that the joint use of angular and spectral information without a prescribed biome map or training data results in comparable accuracy to LAI values obtained from single-angle retrievals that require a pre-defined biome map. The multiangle algorithm can therefore adapt to changing or unknown land cover.
The Extracellular Matrix Protein MAGP1 Is a Key Regulator of Adipose Tissue Remodeling During Obesity (2014)

In response to increases in fat mass, as seen in obesity, the adipose tissue undergoes distinct structural remodeling (1). Recent attention has focused on the importance of the extracellular matrix (ECM) in remodeling of adipose tissue during the development of obesity. The ECM not only provides structural support to the surrounding cells, but also plays a crucial role in the biological function of different organs. Components of the ECM include structural proteins, such as collagen and fibrillins, and various classes of adhesion proteins, such as fibronectin and proteoglycan.

Fibrillins are large proteins that form extracellular microfibril suprastructures ubiquitously found in elastic and nonelastic tissues. Constitutive components of the microfibrils also include the microfibril-associated glycoproteins (MAGPs) 1 and 2 (2,3). Microfibrils appear to have dual roles: They confer mechanical stability and limited elasticity to tissues and modulate the activity of members of the transforming growth factor-β (TGF-β) superfamily (4–6). The importance of microfibrils in regulating TGF-β activity is illustrated by the phenotype associated …
Alteration of chloroquine accumulation in human polymorphonuclear leucocytes under inflammatory conditions. (1987)

The present study concerns the established antirheumatic drug chloroquine (CQ) in relation to a possible target for drug therapy, the polymorphonuclear leucocyte (PMN). Its primary aim was to find out whether inflammatory conditions would influence the cell association of CQ. After a suitable ligand-binding assay was developed to measure the cellular association of CQ, the normal characteristics of the cellular transport of CQ were determined. The effect of the inflammatory conditions on CQ cell association was investigated with peripheral PMNs from rheumatoid arthritis (RA) patients, and with normal PMNs, in the absence and presence of the soluble cell-stimulators phorbol ester and chemotactic peptide. Under inflammatory conditions the intracellular concentration of CQ is reduced. This decrease is explained by three possibilities which are involved in cell activation: the leucocyte volume expansion, the cytoplasmic or lysosomal pH changes, and the exocytic release of the granules (degranulation). Our results suggest that this decrease will adversely affect the therapeutic effects, if the mode of anti-inflammatory action of CQ is related to the intracellular drug concentrations.
[Computer-assisted medical decision]. (1996)

A physician deals everyday with uncertainty to take decisions and treat patients. The goal of decision making systems is to facilitate and improve the decision. Classical approaches, such as decision trees or statistical tools, provide rates about possible actions and outcomes of physicians' decisions. Such information is essentially numerical. Other computer approaches, like expert systems, provide both numeric and symbolic information. The expert knowledge is embedded in the system and used to elaborate new decisions and to provide reasoning explanations. The use of computer making decision systems will certainly increase the performances in future medical activity as it will provide a reliable additional expert information to take decisions.
Different Strokes in Different Folks: Unique Molecular Signatures of Cortical and Deep Brain Infarcts (1997)

Editorials| September 15 1997 Different Strokes in Different Folks: Unique Molecular Signatures of Cortical and Deep Brain Infarcts Subject Area: Cardiovascular System , Neurology and Neuroscience Stephen G. Waxman Stephen G. Waxman Department of Neurology, Yale University School of Medicine, New Haven, Conn., and Neuroscience Research Center, VA Medical Center, West Haven, Conn., USA Search for other works by this author on: This Site PubMed Google Scholar Cerebrovasc Dis (1997) 7 (5): 243–244. https://doi.org/10.1159/000108201 Article history Published Online: September 15 1997 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Stephen G. Waxman; Different Strokes in Different Folks: Unique Molecular Signatures of Cortical and Deep Brain Infarcts. Cerebrovasc Dis 1 May 1997; 7 (5): 243–244. https://doi.org/10.1159/000108201 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsCerebrovascular Diseases Search Advanced Search This content is only available via PDF. 1997Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
ChemInform Abstract: Ring Transformation of Fused Pyridazines. Part 4. Reaction of Halo‐ Substituted Fused Pyridazines with Ynamines. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Performance-based Design of Civic Buildings (2016)

<p>Courthouses and government buildings have an important role in providing order and service to the public. They are required to be functional following extreme events, including natural disasters such as extreme wind events and earthquakes, or blast and ballistic threats.</p><p>This paper emphasizes the design efforts and challenges encountered during the design phase and construction of the San Diego Central Courthouse, New San Bernardino Justice Center, and the New Los Angeles Federal Courthouse. Each of these structures utilizes innovative technologies like viscous damping devices to supplement ductile Special Moment Frame, Triple Concave-Friction Pendulum bearings and Buckling Restrained Braces to achieve enhanced seismic and blast resistant structures. The goal of designing resilient structures beyond code prescriptive methods were met, while efficiently utilizing community’s civic resources. This paper also summarizes the seismic risk and life-cycle assessments that were completed to assist decision making in the selection of alternative structural systems leading to cost- effective enhanced seismic and security performance objectives.</p>
Synthesis of Purine and Pyrimidine Trihydroxyacyclonucleosides (1984)

Abstract The [[3-hydroxy-2-bis(hydroxymethyl)-l-propoxy]methyl] derivatives of adenine, guanine, cytosine and thymine have been synthesized and tested against herpesviruses.
Patented small molecule inhibitors of HIV-1 integrase: a 10-year saga (2002)

AbstractValidation of integrase as a suitable therapeutic target for the development of drugs against HIV infection; discovery of diketo acid derivatives as bona fide inhibitors of integrase and the recent news of Phase II clinical trials with S-1360 are major findings fuelling the recent surge of interest in the development of integrase inhibitors. Herein, the first review of the entire patent literature for small molecule intergrase inhibitors is presented. The emphasis is based on compounds with potential to serve as leads, therefore, no attempts are made to include: antibodies, oligonucleotides or polypeptides.Keywordsdiketoacidsdrug discoveryHIV-1 integraseinhibitor designnatural productsS-1360
Stochastic petri nets modeling using spn@ (2006)

This paper introduces SPN@, a tool for the graphical modeling of intricate dynamics scenarios relevant to safety, reliability, and availability. Implemented in SPN@ is a novel concept of aging tokens, enhancing colored stochastic Petri net formalism, and providing a visual and practical means for assessing complex dynamic scenarios. The examples provided serve to indicate a wide range of practical applications of SPN@, including a classical problem of shared load, repairable system with parallel tasks, and modeling of a system that undergoes both preventive and corrective maintenance with the associated consideration of risk trade offs
p38 Kinase Is Activated in the Alzheimer's Disease Brain (1999)

The p38 mitogen-activated protein kinase is a stress-activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age-matched normal brain. Intense phospho-p38 immunoreactivity was associated with neuritic plaques, neuropil threads, and neurofibrillary tangle-bearing neurons. The antibody against phosphorylated p38 recognized many of the same structures as an antibody against aberrantly phosphorylated, paired helical filament (PHF) tau, although PHF-positive tau did not cross-react with the phospho-p38 antibody. These findings suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components.
Cold-developed electron-beam-patterned ZEP 7000 for fabrication of 13 nm nickel zone plates (2009)

Cold development was applied to improve the resolution in a trilayer resist that is used for the fabrication of state-of-the-art soft x-ray microscopy zone plates. By decreasing the temperature of the hexyl acetate developer to −50 °C, 11 nm half-pitch gratings have been resolved in the electron-beam resist ZEP 7000. 12 nm half-pitch gratings have been successfully transferred, via the intermediate SiO2 hardmask, into the bottom polyimide layer by CHF3 and O2 reactive ion etching. The trilayer resist, including optimized cold development, has finally been used in an electroplating-based process for the fabrication of nickel zone plates. Zone plates with down to 13 nm outermost zone width have been fabricated and 2.4% average groove diffraction efficiency has been measured for zone plates with 15 nm outermost zone width and a nickel height of 55 nm.
Markers are shared between adipogenic and osteogenic differentiated mesenchymal stem cells (2013)

The stem cell differentiation paradigm is based on the progression of cells through generations of daughter cells that eventually become restricted and committed to one lineage resulting in fully differentiated cells. Herein, we report on the differentiation of adult human mesenchymal stem cells (hMSCs) towards adipogenic and osteogenic lineages using established protocols. Lineage specific geneswere evaluated by quantitative real-time PCR relative to two reference genes. The expression of osteoblast-associated genes (alkaline phosphatase, osteopontin, and osteocalcin)was detected in hMSCs that underwent adipogenesis. When normalized, the expression of adipocyte marker genes (adiponectin, fatty acid binding protein P4, and leptin) increasedin a time-dependent manner during adipogenic induction. Adiponectin and leptin were also detected in osteoblast-induced cells. Lipid vacuoles that represent the adipocyte phenotype were only present in the adipogenic induction group. Conforming to the heterogeneous nature of hMSCs and the known plasticity between osteogenic and adipogenic lineages, these data indicatea marker overlap between MSC-derived adipocytes and osteoblasts. Weproposea careful consideration of experimental conditions such as investigated timepoints, selected housekeeping genesand the evidence indicating lack of differentiation into other lineageswhen evaluating hMSC differentiation.
Ni(II) Phenoxyiminato Olefin Polymerization Catalysis: Striking Coordinative Modulation of Hyperbranched Polymer Microstructure and Stability by a Proximate Sulfonyl Group (2014)

The synthesis, structural characterization, and ethylene polymerization properties of two neutrally charged Ni(II) phenoxyiminato catalysts are compared and contrasted. Complex FI-SO2-Ni features a −SO2– group embedded in the ligand skeleton, whereas control FI-CH2-Ni has the −SO2– replaced by a −CH2– functionality. In comparison with FI-CH2-Ni, at 25 °C, FI-SO2-Ni is 18 times more active, produces polyethylene with 3.2 times greater MW and 1.5 times branch content, and is significantly more thermally stable. The FI-SO2-Ni-derived polymer is a hyperbranched polyethylene (148 branches 1000 C–1, MW = 3500g mol–1) versus that from FI-CH2-Ni (98 branches 1000 C–1, MW = 1100g mol–1). DFT calculations argue that the distinctive FI-SO2-Ni catalytic behavior versus that of FI-CH2-Ni is associated with nonnegligible OSO···Ni interactions involving the activated catalyst.
ChemInform Abstract: Further Evidence for the Role of dπ‐pπ Bonding in Rhodium‐ Mediated Hydroborations. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impact of Morphing-Based Frame Synthesis on Bandwidth Optimization for 3DTI Video (2013)

In view of the resource demanding nature of 3D Tele-immersion (3DTI), we apply Morphing-based Frame Synthesis (MBFS) on delivery of both online and offline 3DTI visual content to decrease the resource consumption without degrading the perceptual quality. We further investigate the relationship between the level-of-motion of the content and the effectiveness of MBFS. In light of the results, we propose an on-the-fly resource adaptor for 3DTI video transmission which utilizes a perceptual model built from data compiled by a series of subjective experiments. Results show that our adaptor achieves 43% to 87% compression ratio for offline compression on 3DTI videos of different baseline user activities, and a 10% on-the-fly bandwidth saving on complex user activity without perceptible degradation.
TOXICITY, ANTICANCER AND ANTIOXIDANT ACTIVITY OF EXTRACTS FROM MARINE BACTERIA ASSOCIATED WITH SPONGE Jaspis sp. (2014)

Sponges associated with microorganism can produce bioactive compounds such as antioxidant and anticancer. The aim of this study determines the toxicity, anticancer and antioxidant potency of marine bacteria which associated with sponges Jaspis sp. The bioactive compounds were extracted with ethyl acetate. The toxicity of extract was analyzed trough by brine shrimp lethality test (BSLT), while anticancer activity againts HeLa cell was analyzed by MTT assay and antioxidant capacity was analyzed by cupric ion reducing antioxidant capacity (CUPRAC) assay. The result showed that extract consisted of flavonoid, alkaloid, and triterpenoid which were potential as an antioxidant and anticancer. The extract had a toxic effect with the range LC50 value was 251.18 to 390.50 µg/mL. The extract could inhibited HeLa cell in the range IC50 value was 242.54 to 267.03 µg/mL. Antioxidant capacity of extract were ranged from 156.94 to 649.92 µmol trolox/g extract.
ChemInform Abstract: Charge as a Key Component in Reaction Design. The Invention of Cationic Cyclization Reactions of Importance in Synthesis (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification and assessment of the role of a nominal phospholipid binding region of ORP1S (oxysterol-binding-protein-related protein 1 short) in the regulation of vesicular transport (2005)

The ORPs (oxysterol-binding-protein-related proteins) constitute an enigmatic family of intracellular lipid receptors that are related through a shared lipid binding domain. Emerging evidence suggests that ORPs relate lipid metabolism to membrane transport. Current data imply that the yeast ORP Kes1p is a negative regulator of Golgi-derived vesicular transport mediated by the essential phosphatidylinositol/phosphatidylcholine transfer protein Sec14p. Inactivation of Kes1p function allows restoration of growth and vesicular transport in cells lacking Sec14p function, and Kes1p function in this regard can be complemented by human ORP1S (ORP1 short). Recent studies have determined that Kes1p and ORP1S both bind phospholipids as ligands. To explore the function of distinct linear segments of ORP1S in phospholipid binding and vesicular transport regulation, we generated a series of 15 open reading frames coding for diagnostic regions within ORP1S. Purified versions of these ORP1S deletion proteins were characterized in vitro, and allowed the identification of a nominal phospholipid binding region. The in vitro analysis was interpreted in the context of in vivo growth and vesicle transport assays for members of the ORP1S deletion set. The results determined that the phospholipid binding domain per se was insufficient for inhibition of vesicular transport by ORP1S, and that transport of carboxypeptidase Y and invertase from the Golgi may be regulated differentially by specific regions of ORP1S/Kes1p.
Cross Reactivity of Human Recombinant thrombin (Recothrombin) to Antibovine Thrombin Antibodies. Clinical Implications (2009)

Bovine thrombin preparations are widely used topical hemostatic agents. Whereas older bovine thrombin preparations were reported to produce immunologic responses upon repeated exposure, the newly introduced recombinant human thrombin preparation (Zymogenetics, Seattle, WA, USA) and bovine thrombin preparations purified by membrane filtration are claimed to be less immunogenic. Despite their reduced immunogenic nature, repeated administration of purified bovine thrombin preparations can result in the generation of antibovine thrombin antibodies. In this study, groups of rabbits were challenged repeatedly with bovine thrombin over a 6 months period and purified IgG preparations were obtained using protein G columns. In order to determine their cross reactivity with human recombinant thrombin (Recothrombin), two batches of this agent were evaluated by immunoblotting techniques using the rabbit IgG fractions. Recothrombin preparations cross reacted with the rabbit antibovine thrombin IgG. The cross reactivity of Recothrombin with antibodies was time dependent and a progressive increase in the immunoreactivity was evident. These results demonstrate that human recombinant thrombin can cross react with antibodies to bovine thrombin. Thus, the use of Recothrombin may not be recommended in patients previously treated/exposed to bovine thrombin.
Potential use of Tunisian<i>Pituranthos chloranthus</i>essential oils as a natural disinfectant (2008)

This natural disinfectant could play a vital role in alleviating the spread of pathogenic micro-organisms and environmental problems associated with the indiscriminate use of synthetic chemicals.
TRANSESOPHAGEAL ECHOCARDIOGRAPHY FOR DIAGNOSING AORTIC INJURY (1994)

Early diagnosis and rapid treatment of lethal aortic injuries associated with blunt trauma remain a challenge for trauma surgeons. The following case demonstrates the use of transesophageal echocardiography for definitive diagnosis of an aortic injury from blunt trauma. A summary of current diagnostic modalities is also presented.
Hepatitis B core antigen forms oligomers and complexes with the <i>p</i> gene product in hepatitis B virus core particles (1993)

Abstract The nucleocapsid core of hepatitis B virus (HBV) is composed of the hepatitis B core antigen (HBcAg), a viral genome, a polymerase and a protein covalently linked to the 5'‐end of the minus DNA strand. The interactions among the constituents are still very limited. By using the in vitro phosphorylation method, it was found that the p gene product formed complexes with HBcAg in the core particles through non‐covalent linkage. After complete digestion of the HBV genome, the complexes between the HBcAg and p gene product remained intact. These results indicate that the HBcAg and p gene product are not complexed through the HBV genome. Also, it was found that the 21 kD HBcAg formed oligomers through disulfide linkages in the extracellular viral particles.
Dynamic Beam Propagation Method for Modelling Pulse Propagation in Flared Semiconductor Laser Amplifiers (1996)

Mode-locked semiconductor laser diodes are excellent for generating, e.g., solitons and blue light by second-harmonic generation in bulk crystals. However, until recently, the output pulse energy has been limited by the low saturation energy (about 1 pJ) of single lateral-mode semiconductor amplifiers. By using flared semiconductor laser-diode amplifiers, the saturation energy, and thereby the output power can be increased by two orders of magnitude [1],[2].