gebhart/patrepeval huggingface dataset:
A survey of ranking, selection, and multiple comparison procedures for discrete-event simulation (2003)

Article Free Access Share on A survey of ranking, selection, and multiple comparison procedures for discrete-event simulation Authors: James R. Swisher Lotus Biochemical Corporation, 7335 Lee Highway, Radford, VA Lotus Biochemical Corporation, 7335 Lee Highway, Radford, VAView Profile , Sheldon H. Jacobson Department of Mechanical and Industrial Engineering, University of Illinois at Urbana-Champaign, Urbana, IL Department of Mechanical and Industrial Engineering, University of Illinois at Urbana-Champaign, Urbana, ILView Profile Authors Info & Claims WSC '99: Proceedings of the 31st conference on Winter simulation: Simulation---a bridge to the future - Volume 1December 1999 Pages 492–501https://doi.org/10.1145/324138.324307Published:01 December 1999Publication History 9citation634DownloadsMetricsTotal Citations9Total Downloads634Last 12 Months28Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Tardive dyskinesia in dopa-responsive dystonia: A reappraisal of the dopamine hypothesis of tardive dyskinesia (1998)

Dopa-responsive dystonia, an autosomal-dominant disorder caused by mutations in the guanosine triphosphate (GTP)-cyclohydrolase I gene, is characterized by severe striatal dopamine depletion. Tardive dyskinesia, on the other hand, has often been associated with striatal dopamine overactivity. This article reports on a 44-year-old man with dopa-responsive dystonia who developed tardive dyskinesia on long-term haloperidol therapy. Nigrostriatal dopamine deficiency may be necessary for the development of tardive dyskinesia.
3-Transistor antifuse OTP ROM array using standard CMOS process (2004)

A 3-transistor cell CMOS OTP ROM array using CMOS antifuse (AF) based on permanent breakdown of MOSFET gate oxide is proposed, fabricated and characterized. The proposed 3-T OTP cell for ROM array is composed of an nMOS AF, a high voltage (HV) blocking nMOS, and cell access transistor, all compatible with standard CMOS technology. The experimental results show that the proposed structure can be a viable technology option as a high density OTP ROM array for modern digital as well as analog circuits.
Development and Characterization of Polysiloxane Polymer Films for Use in Optical Sensor Technology (2008)

Finally, I would like to acknowledge my
The induction of operational tolerance is not prevented by simultaneous administration of cyclosporin A 1 (1997)

In this study, the effect of combining anti-CD4 monoclonal antibody (mAb) and cyclosporin (CyA) therapy at the time of transplantation was examined. A mouse cardiac allograft model was used. Anti-CD4 mAb administered perioperatively induces long-term survival. The addition of a short course of CyA given subcutaneously in a regimen of either a high-dose treatment or a standard dose treatment to the anti-CD4 mAb treatment protocol did not have a detrimental effect on graft survival. Despite having no significant effect on graft survival, the addition of CyA to the treatment protocol did result in a significant decrease in the level of IL-2 present in the hearts 7 days after transplantation. The decrease in IL-2 production was directly related to the presence of CyA in vivo. When CyA treatment was continued throughout the period during which unresponsiveness to the graft is induced by anti-CD4 mAb therapy, 50% of the grafted hearts were rejected once the CyA was discontinued. In conclusion, the combined use of anti-CD4 mAb therapy and CyA did not have a negative effect on graft survival in this model when the two agents were used concurrently at the time of transplantation.
Heat shock proteins 70 and 90 from Clonorchis sinensis induce Th1 response and stimulate antibody production (2017)

This study showed for the first time that the HSP or HSP/peptide complexes of C. sinensis could be considered as a more effective vaccine against C. sinensis infection as results of the activator of host immune response as well as the adjuvant for antigenic peptide conjugate to induce peptide-specific antibody response in mice.
Ethnic America: A History (1981)

This classic work by the distinguished economist traces the history of nine American ethnic groups--the Irish, Germans, Jews, Italians, Chinese, African-Americans, Puerto Ricans, and Mexicans.
Digital Redesign Of Continuous‐Time Suboptimal Tracker For Two‐Dimensional Systems (2003)

ABSTRACT In this paper, the digital redesign of a continuous suboptimal tracker for the two‐dimensional (2‐D) systems is proposed. This paper presents a new optimal digital redesign technique of 2‐D systems for finding a dynamic digital control law from the given continuous‐time 2‐D systems by minimizing a quadratic cost function (performance index). We directly convert the original continuous‐time 2‐D quadratic cost function into the discretized form and solve the optimization problem in the discrete‐time domain. The developed optimal digital redesign control law enables the output of the digitally controlled closed‐loop systems to closely match the reference signal for 2‐D systems, and it can be easily implemented using microcomputers. An illustrative example is presented to demonstrate the effectiveness of the proposed procedure.
Editorial of The Open Access Journal of Science and Technology Journal (2020)

21st International conference on Smart Materials and Polymer Technology organized in Paris, France. during March 22-23, 2021. Smart Materials 2021 initiates an as well as the novel applications of smart emerging materials in materials science. Content science professionals gathered around the world to learn about the latest developments and innovations as well as novel applications of smart emerging materials. Smart Materials & Polymer Technology Conference 2021 is a 2-day program
that offers exhibition at the venue to display new and emerging technologies and has extensive sessions in which the main Keynote presentation, YRF (student presentation), Oral, Posters, E-poster presentations. To share their valuable presentation on the most recent and advanced techniques, development and latest updates, a world-renowned speaker and prominent representative representatives from all over the world participate in the conference.
Whither the Area in Area Studies? How Students Teach Us to Rethink the Boundaries of Eastern Europe (2006)

Abstract The authors examine the state of the field of Russian and East European area studies by bringing student perspectives into dialogue with leading scholarly perspectives on the direction of area studies. They argue that the collapse of communism and increasing globalization do not necessitate the elimination of area studies. Instead, area studies helps to contextualize the shared histories and experiences of neighboring states as well as local particularities within the increasing integration of Europe.
Rethinking computer science education from a test-first perspective (2003)

Despite our best efforts and intentions as educators, student programmers continue to struggle in acquiring comprehension and analysis skills. Students believe that once a program runs on sample data, it is correct; most programming errors are reported by the compiler; when a program misbehaves, shuffling statements and tweaking expressions to see what happens is the best debugging approach. This paper presents a new vision for computer science education centered around the use of test-driven development in all programming assignments, from the beginning of CS1. A key element to the strategy is comprehensive, automated evaluation of student work, in terms of correctness, the thoroughness and validity of the student's tests, and an automatic coding style assessment performed using industrial-strength tools. By systematically applying the strategy across the curriculum as part of a student's regular programming activities, and by providing rapid, concrete, useful feedback that students find valuable, it is possible to induce a cultural shift in how students behave.
Úvod (2012)

ÚVoDv říjnu loňského roku jsme si připomněli padesáté výročí zahájení 2. vatikánského koncilu, svolaného papežem Janem XXiii.k pastorační a ekumenické obnově církve.dialog s moderním světem, k němuž vybízel ve své nástupní encyklice pavel vi., se stal leitmotivem koncilního snažení.a právě k této klíčové události moderních dějin katolické církve i teologie se vrací dva první příspěvky.přední český teolog ctirad v. pospíšil ve svém příspěvku inspirace koncilní konstituce dei verbum a upozorňuje na další vývoj teologické reflexe v dané oblasti.připomíná nedostatečné zpracování problematiky tzv
Artificial Induction of Lactation in Cattle by Use of Dexamethasone Trimethylacetate (1975)

Injections of dexamethasone trimethylacetate initiated lactation in nulliparous Ayrshire heifers previously given a series of injections of oestradiol benzoate plus progesterone to develop mammary glands. Essentially normal lactation occurred following injection of 20 mg/day dexamethasone for 3 days, whereas injection of 40 mg/day for 4 days initiated secretion of smaller volumes of milk-like fluid containing relatively high levels of lipid. Milking alone failed to initiate lactation.
Fine-Tuning Vitamin E-Containing Telodendrimers for Efficient Delivery of Gambogic Acid in Colon Cancer Treatment (2015)

Certain natural products such as gambogic acid (GA) exhibit potent antitumor effects. Unfortunately, administration of these natural products is limited by their poor solubility in conventional pharmaceutical solvents. In this study, a series of telodendrimers, composed of linear polyethylene glycol (PEG)-blocking-dendritic oligomer of cholic acid (CA) and vitamin E (VE), have been designed with architectures optimized for efficient delivery of GA and other natural anticancer compounds. Two of the telodendrimers with segregated CA and VE domains self-assembled into stable cylindrical and/or spherical nanoparticles (NPs) after being loaded with GA as observed under transmission electron microscopy (TEM), which correlated with the dynamic light scattering (DLS) analysis of sub-30 nm particle sizes. A very high GA loading capacity (3:10 drug/polymer w/w) and sustained drug release were achieved with the optimized telodendrimers. These novel nanoformulations of GA were found to exhibit similar in vitro cytotoxic activity against colon cancer cells as the free drug. Near-infrared fluorescence small animal imaging revealed preferential accumulation of GA-loaded NPs into tumor tissue. The optimized nanoformulation of GA achieved superior antitumor efficacy compared to GA-Cremophor EL formulation at equivalent doses in HT-29 human colon cancer xenograft mouse models. Given the mild adverse effects associated with this natural compound and the enhanced anticancer effects via tumor targeted telodendrimer delivery, the optimized GA nanoformulation is a promising alternative to the traditional chemotherapy in colon cancer treatment.
The IONWI Algorithm: Learning when and when not to interrupt (2006)

One of the key issues for an interface agent to succeed at assisting a user is learning when and when not to interrupt him to provide him assistance. Unwanted or irrelevant interruptions hinder the user’s work and make him dislike the agent because it is being intrusive and impolite. The IONWI algorithm enables interface agents to learn a user’s preferences and priorities regarding interruptions. The resulting user profile is then used by the agent to personalize the modality of the assistance, that is, assisting the user with an interruption or without an interruption depending on the user’s context. Experiments were conducted in the calendar management domain, obtaining promising results.
Screening of Inhibitory Activity of Edible Mushrooms on the Monoamine Oxidase (1997)

The monoamine oxidase (MAO, EC 1.4.3.4) plays a central role in the metabolism of many amines including the neurotransmitter monoamines. MAO is a flavoprotein found exclusively in the mitochondrial outer membrane, occuring in the MAO-A and MAO-B subtypes. MAO-A deaminates serotonin and noradrenaline much better than phenethylamine (PEA) or benzylamine (BA), and is preferentially inhibited by clorgyline, whereas MAO-B prefers PEA and BA as substrates and is preferentially inhibited by deprenyl. MAO inhibitors were among the first drugs used in the treatment of depression, and it is known to be the inhibition of MAO-A which is important for the antidepressant effect of MAO inhibitors. For the purpose of evaluating MAO inhibitory activities from natural resources, three kinds of edible mushrooms were screened by tracing the inhibitory activities against rat brain mitochondrial MAO-A, utilizing serotonin as a substrate and rat liver mitochondrial MAO-B utilizing benzylamine as a substrate. Among the tested mushrooms, Ganoderma lucidium and Lentinus edodes showed the weak inhibitory activities against MAO-B.
Experiments on mixing due to chaotic advection in a cavity (1989)

Chaotic mixing of fluids in slow flows is ubiquitous but incompletely understood. However, relatively simple experiments provide a wealth of information regarding mixing mechanisms and indicate the need for complementary theoretical developments in dynamical systems. In this work we presnt a versatile cavity flow apparatus, capable of producing a variety of two-dimensional velocity fields, and use it to conduct a detailed experimental study of mixing in low-Reynolds-number flows. Since the goal is detailed understanding, only two time-periodic co-rotating flows induced by wall motions are considered: one continuous and the other discontinuous. Both types of flows produce exponential growth of intermaterial area, as expected from chaotic flows, and a mixture of islands and chaotic regions. A procedure for identifying periodic points and determining their movements is presented as well as how to make meaningful comparisons between periodic flows. We observe that periodic points move very much as a planetary system; planets (hyperbolic points) have moons (elliptic points) with twice the period of the planets; furthermore the spatial arrangement of periodic points becomes symmetric at regular time intervals. Detailed analyses reveal complex behaviour: birth, bifurcation, and collapse of islands; formation and periodic motion of coherent structures, such as islands and large-scale folds. However, the richness and complexity of the results obtained indicate that these two-dimensional time-periodic systems are far from completely understood and that other wall motions might deserve a similar level of scrutiny.
COALESCENCE AS A FACTOR IN SOLVENT STIMULATION OF PLASTID PHOSPHATIDASE C ACTIVITY (1957)

Solvents which stimulate plastid phosphatidase C activity (e.g., ethyl ether, propyl ketone, and ethyl butyrate) have been observed (microscopically) to produce coalescence of lecithin and chloroplast phases, while those which do not stimulate the reaction (e.g., chloroform and petroleum ether) do not produce coalescence. In the ethyl ether-stimulated reaction, all of the original enzymatic activity was associated with the coalesced material, and the lecithin apparently formed an ether-insoluble complex with the chloroplasts; no enzymatic activity appeared in either the aqueous or ether phases. Ether extraction of chloroplasts alone did not liberate the enzyme from the plastids, and the presence of this stimulating solvent was still necessary for reaction with the substrate to occur. It is concluded that stimulating solvents achieve their effect primarily by causing substrate and plastid phases to coalesce and that the enzymatic reaction actually proceeds in the coalesced phase.
Salt and water absorption in the human colon: a modern appraisal (1998)

The past 20 years have seen many advances in all aspects of colonic physiology, and the unrelenting appearance of new information is daunting to clinicians and scientists alike. Nevertheless, we should not lose sight of the fact that the main function of the human colon is to absorb about 90% of the 1.5–2 litres of ileal effluent which passes daily through the ileocaecal valve.1 2 In mammalian species, the key determinant of colonic water absorption is the rate of Na+ absorption. We now know that Na+ transport processes are not distributed uniformly throughout the human colon, a concept which has important clinical implications. This review provides an update on the basic mechanisms underlying salt and water transport in the human colon in health and disease, and highlights several interesting areas for future research.

The human colon has a nominal mucosal surface area of about 2000 cm2,3 but in reality the total absorptive area is even greater because colonic crypt cells are capable of absorption as well as secretion.4 Although it is well established that the rates of colonic salt (Na+ plus Cl−) and water absorption are directly related,5 it is only recently that we have begun to appreciate the array of Na+absorptive processes present in human colon. These show considerable intrinsic segmental heterogeneity.6-10 This explains, at least in part, why the colon’s capacity for sodium and water absorption in vivo is greater in the proximal (ascending) segment than in the distal (descending and sigmoid colon/rectum) segment.11-15 Several different active (transcellular) Na+ absorptive processes exist in human colon. It will become clear that segmental differences in the distribution and regulation of these processes play an important role in colonic Na+ salvage during periods of salt …
Complexity of Agonist- and Cyclic AMP-Mediated Downregulation of the Human β<sub>1</sub>-Adrenergic Receptor:  Role of Internalization, Degradation, and mRNA Destabilization (2002)

Prolonged agonist exposure often induces downregulation of G protein-coupled receptors (GPCRs). Although downregulation of the prototypical beta(2)-adrenergic receptor (beta(2)AR) has been extensively studied, the underlying mechanisms have yet to be resolved. As even less is known about the beta(1)-subtype, we investigated the downregulation of human beta(1)AR stably expressed in Chinese hamster fibroblasts in response to the agonist isoproterenol or the cell-permeable, chlorophenylthio-cAMP (CPT-cAMP). While either effector mediated decreases in both beta(1)AR binding activity and steady-state beta(1)AR mRNA levels, there were significant differences in their actions. Whereas agonist-mediated downregulation of beta(1)AR followed first-order kinetics, that induced by CPT-cAMP was delayed for several hours and approximately 50% of the former. Furthermore, agonist but not CPT-cAMP induced beta(1)AR internalization, and inhibiting internalization also suppressed agonist-mediated downregulation. The latter, however, was more sensitive than the former to agonist concentration (EC(50) of 0.3 vs 48 nM). Thus, at < or =1 nM agonist, downregulation occurred without internalization and with a pattern similar to that mediated by CPT-cAMP. The amounts of beta(1)AR downregulated or internalized were proportional to initial receptor levels but reached saturation at approximately 2 and 3 pmol/mg of protein, respectively. The fate of beta(1)AR protein during downregulation was determined by immunoblotting with anti-C-terminal antibodies. In agonist-treated cells, beta(1)AR protein disappeared with time and without any immunoreactive degradation products. Agonist-mediated downregulation of the human beta(1)AR appears to be a complex process that consists of both agonist- and cAMP-specific components. The former involves both receptor internalization and degradation whereas the latter involves a reduction in receptor mRNA.
Optical fibre sensing using light scattering techniques (1987)

The combined use of optical fibres and light scattering techniques for sensing, in the pursuit of new scientific and industrial instrumentation, is reviewed at an introductory level.
Characterization of GM events by insert knowledge adapted re-sequencing approaches (2013)

Detection methods and data from molecular characterization of genetically modified (GM) events are needed by stakeholders of public risk assessors and regulators. Generally, the molecular characteristics of GM events are incomprehensively revealed by current approaches and biased towards detecting transformation vector derived sequences. GM events are classified based on available knowledge of the sequences of vectors and inserts (insert knowledge). Herein we present three insert knowledge-adapted approaches for characterization GM events (TT51-1 and T1c-19 rice as examples) based on paired-end re-sequencing with the advantages of comprehensiveness, accuracy, and automation. The comprehensive molecular characteristics of two rice events were revealed with additional unintended insertions comparing with the results from PCR and Southern blotting. Comprehensive transgene characterization of TT51-1 and T1c-19 is shown to be independent of a priori knowledge of the insert and vector sequences employing the developed approaches. This provides an opportunity to identify and characterize also unknown GM events.
Meta-analysis of in vitro and in vivo studies of the biological effects of low-level millimetre waves (2021)

Many of the findings of this meta-analysis have not been reported before and have important implications for overall interpretation of in vitro and in vivo data. Overall, the results of this study do not confirm an association between low-level MMWs and biological effects.
Flora of Oregon. Volume 2 (2021)

Stephen C. Meyers, Thea Jaster, Katie E. Mitchell, Tanya Harvey, and Linda K. Hardison, eds. 2020. Flora of Oregon. Volume 2: Dicots A–F. (ISBN-13: 978-1-889878-61-4, hbk). Botanical Research Institute of Texas Press, 1700 University Dr., Fort Worth, Texas 76107-3400, U.S.A. (Orders: shop.brit.org, orders@brit.org, 1-817-332-4441). $85.00 US, 880 pp., 785 b/w figs., distribution maps, 96 landscape color photos, 7.5 × 10.5.
Creating Effective JavaHelp (2000)

Preface 1. Understanding JavaHelp What Is JavaHelp? Using JavaHelp for Online Documentation Understanding the Files in a HelpSet Following the JavaHelp Process Installing JavaHelp on Your Computer Seeing JavaHelp in Action Deciding How to Present a HelpSet Deciding How to Install a HelpSet Encapsulating HelpSet Files Finding More Information on JavaHelp 2. Creating Your First HelpSet Creating the HelpSet's Directory Structure Creating HelpSet Data and Navigation Files Creating Help Topic Files Checking Your Work Testing the Finished HelpSet 3. Planning the JavaHelp Project General Planning Tasks Planning Tasks Specific to JavaHelp 4. Preparing Help Topics Planning Your Help Topics Creating Help Topics and Applying Appropriate HTML Tags Writing Effective and Meaningful Help Topics Using Preexisting HTML Topic Files 5. Creating HelpSet Data and Navigation Files Understanding XML Creating the HelpSet File Assigning Map IDs to Help Topics Specifying the Navigation Components 6. Enhancing the HelpSet Creating Pop-up and Secondary Windows Customizing the Navigation Facility Merging HelpSets 7. Using the JavaHelp API for Advanced Presentation Options The TypeFacer Application Invoking Help with a Button, Menu Item, or Key Using Screen-Level Context-Sensitive Help Using Field-Level Context-Sensitive Help Embedding Help into the Application 8. Deploying the Help System to Your Users Encapsulating the HelpSet Delivering All the Required Files Ensuring Basic Java Support 9. Using Third-Party Help-Authoring Tools How JavaHelp Relates to Third-Party Tools How Third-Party Tools Work A. HelpSet Tags B. Lightweight Component Tags C. The JavaHelp API D. TypeFacer.java Source Listing Glossary Index