gebhart/patrepeval huggingface dataset:
Cross-species regulatory sequence activity prediction (2020)

Machine learning algorithms trained to predict the regulatory activity of nucleic acid sequences have revealed principles of gene regulation and guided genetic variation analysis. While the human genome has been extensively annotated and studied, model organisms have been less explored. Model organism genomes offer both additional training sequences and unique annotations describing tissue and cell states unavailable in humans. Here, we develop a strategy to train deep convolutional neural networks simultaneously on multiple genomes and apply it to learn sequence predictors for large compendia of human and mouse data. Training on both genomes improves gene expression prediction accuracy on held out and variant sequences. We further demonstrate a novel and powerful approach to apply mouse regulatory models to analyze human genetic variants associated with molecular phenotypes and disease. Together these techniques unleash thousands of non-human epigenetic and transcriptional profiles toward more effective investigation of how gene regulation affects human disease.
Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life (2012)

The results indicate that the combination of resveratrol and calcium fructoborate has beneficial effects in patients with angina
Variation with time of the mechanism, observable order, and activation energy of catalyst deactivation by coke in the FCC process (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVariation with time of the mechanism, observable order, and activation energy of catalyst deactivation by coke in the FCC processJose Corella, Rafael Bilbao, Jose A. Molina, and Alfonso ArtigasCite this: Ind. Eng. Chem. Process Des. Dev. 1985, 24, 3, 625–636Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://pubs.acs.org/doi/10.1021/i200030a018https://doi.org/10.1021/i200030a018research-articleACS PublicationsRequest reuse permissionsArticle Views253Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Investigation of the dynamics of the structure of biopolymers by the method of kinetic spectrofluorometry (1986)

A system for kinetic spectroscopy was developed and used to measure the kinetic characteristics of the intrinsic fluorescence of the dipeptide Trp–Trp and to separate the spectral-kinetic components corresponding to different indole chromophores of the dipeptide. The method of consecutive picosecond fluorescence probing of fast streams of liquid chemical reagents was used to detect changes in the average duration of the fluorescence of the intramolecular chromophores during a single elementary event of enzymic catalysis. New potential applications were found for the laser spectral-kinetic methods in a study of the dynamics of the structure of biological molecules under biochemical reaction and equilibrium conditions.
Underconnected, but How? A Survey of Functional Connectivity MRI Studies in Autism Spectrum Disorders (2011)

Growing consensus suggests that autism spectrum disorders (ASD) are associated with atypical brain networks, thus shifting the focus to the study of connectivity. Many functional connectivity studies have reported underconnectivity in ASD, but results in others have been divergent. We conducted a survey of 32 functional connectivity magnetic resonance imaging studies of ASD for numerous methodological variables to distinguish studies supporting general underconnectivity (GU) from those not consistent with this hypothesis (NGU). Distinguishing patterns were apparent for several data analysis choices. The study types differed significantly with respect to low-pass filtering, task regression, and whole-brain field of view. GU studies were more likely to examine task-driven time series in regions of interest, without the use of low-pass filtering. Conversely, NGU studies mostly applied task regression (for removal of activation effects) and low-pass filtering, testing for correlations across the whole brain. Results thus suggest that underconnectivity findings may be contingent on specific methodological choices. Whereas underconnectivity reflects reduced efficiency of within-network communication in ASD, diffusely increased functional connectivity can be attributed to impaired experience-driven mechanisms (e.g., synaptic pruning). Both GU and NGU findings reflect important aspects of network dysfunction associated with sociocommunicative, cognitive, and sensorimotor impairments in ASD.
Valuable perspectives to help us deal with complexity (2001)

In a complex world, we require certain personal skills, attitudes, beliefs and behaviours to enable us not only to survive but also to thrive. The implications of a complexity perspective as discussed in the preceding chapters call for distinctive attributes, abilities and competence. This means that to be successful project leaders and managers, we have to cultivate certain attitudes and ways of dealing with the world. A crucial step is to acquire and develop useful skills and perspectives. In an uncertain world, we cannot plan for what happens to us but we can be prepared so that we can handle what comes our way.
Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21 (2020)

Psoriasis is a chronic Th1/Th17 lymphocytes-mediated inflammatory skin disease, in which epidermal keratinocytes exhibit a peculiar senescent state, resistance to apoptosis and the acquisition of senescence-associated secretory phenotype (SASP). SASP consists of the release of soluble factors, including IGFBPs, that exert extracellular and intracellular functions in IGF-dependent or independent manner.In this report, we investigated the expression and function of IGFBP2 in senescent keratinocytes isolated from the skin of patients with plaque psoriasis. We found that IGFBP2 is aberrantly expressed and released by these cells <i>in vivo</i>, as well as <i>in vitro</i> in keratinocyte cultures undergoing progressive senescence, and it associates with the cyclin-dependent kinase inhibitors p21 and p16 expression. For the first time, we provide evidence for a dual action of IGFBP2 in psoriatic keratinocytes during growth and senescence processes. While extracellular IGFBP2 counter-regulates IGF-induced keratinocyte hyper-proliferation, intracellular IGFBP2 inhibits apoptosis by interacting with p21 and protecting it from ubiquitin-dependent degradation. Indeed, we found that cytoplasmic p21 sustains anti-apoptotic processes, by inhibiting pro-caspase 3 cleavage and JNK phosphorylation in senescent psoriatic keratinocytes. As a consequence, abrogation of p21, as well as that of IGFBP2, found to stabilize cytoplasmic p21 levels, lead to the restoration of apoptosis mechanisms in psoriatic keratinocytes, commonly observed in healthy cells.
Atrazine, Alachlor, and Cyanazine in a Large Agricultural River System (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAtrazine, Alachlor, and Cyanazine in a Large Agricultural River SystemS. P. Schottler, S. J. Eisenreich, and P. D. CapelCite this: Environ. Sci. Technol. 1994, 28, 6, 1079–1089Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/es00055a017https://doi.org/10.1021/es00055a017research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automated Transmission-Mode Scanning Electron Microscopy (tSEM) for Large Volume Analysis at Nanoscale Resolution (2013)

Transmission-mode scanning electron microscopy (tSEM) on a field emission SEM platform was developed for efficient and cost-effective imaging of circuit-scale volumes from brain at nanoscale resolution. Image area was maximized while optimizing the resolution and dynamic range necessary for discriminating key subcellular structures, such as small axonal, dendritic and glial processes, synapses, smooth endoplasmic reticulum, vesicles, microtubules, polyribosomes, and endosomes which are critical for neuronal function. Individual image fields from the tSEM system were up to 4,295 µm(2) (65.54 µm per side) at 2 nm pixel size, contrasting with image fields from a modern transmission electron microscope (TEM) system, which were only 66.59 µm(2) (8.160 µm per side) at the same pixel size. The tSEM produced outstanding images and had reduced distortion and drift relative to TEM. Automated stage and scan control in tSEM easily provided unattended serial section imaging and montaging. Lens and scan properties on both TEM and SEM platforms revealed no significant nonlinear distortions within a central field of ∼100 µm(2) and produced near-perfect image registration across serial sections using the computational elastic alignment tool in Fiji/TrakEM2 software, and reliable geometric measurements from RECONSTRUCT™ or Fiji/TrakEM2 software. Axial resolution limits the analysis of small structures contained within a section (∼45 nm). Since this new tSEM is non-destructive, objects within a section can be explored at finer axial resolution in TEM tomography with current methods. Future development of tSEM tomography promises thinner axial resolution producing nearly isotropic voxels and should provide within-section analyses of structures without changing platforms. Brain was the test system given our interest in synaptic connectivity and plasticity; however, the new tSEM system is readily applicable to other biological systems.
Asymmetric induction. Part 3. Asymmetric reduction of ketones with amine-boranes in the presence of acids (1981)

Asymmetric reductions of a series of ketones with (+)-1-phenylethylamine–borane and boron trifluoride–diethyl ether are described; solvent and temperature effects have been studied, and the use of other acidic components has been explored. Asymmetric reductions have also been effected with α-amino-ester–boranes (14–23% optical yields) and with diastereoisomeric amine–boranes containing chiral nitrogen atams. 2-Aminoethanols were prepared in high yield by reaction of α-amino-ester–boranes with boron trifluoride.
The Forecast of Power Demand Cycle Turning Points Based on ARMA (2009)

To make decision for power industry development, it is important to known changes of power demand cycle. Firstly ARMA model and its modeling process of time series were introduced, then according to autocorrelation and partial-autocorrelation coefficients of power demand growth rate from year 1980 to year 2005,AR (2) model was chosen to fit the time series of power demand in China. The maximum likelihood method was used to estimate the value of model parameter, the model and parameters were tested by significance test, and the fitting accuracy was analyzed by errors between actual and forecasting value. At last the growth rate of power demand and year 2006-2020 power demand cycle turning points in China were forecasted. The error average of the growth rate of power demand in China between actual and forecasting value is 0.1417, and the mean absolute error of the forecasting is 1.6253, the mean absolute error rate is 23.5%, year 2008 and year 2012 are power demand cycle turning points. The results show that it is a better method using ARMA model to forecast power demand cycle turning points, fitting model is remarkable, the method is reliable, the forecasting precision is high.
Development of an effective swine manure-based algal cultivation system for biofuel & animal feed production and wastewater treatment (2013)

University of Minnesota Ph.D. dissertation.March, 2013. Advisor: Prof. Roger Ruan. Major: Bioproducts/Biosystems Science Engineering and Management. 1 computer file (PDF); xiv, 148 pages.
Three-dimensional beam tracking for optical lever detection in atomic force microscopy (2000)

For the requirement to move a probe with respect to a large specimen like a silicon wafer, a three-dimensional beam tracking for optical lever force detection in atomic force microscopy has been developed. This beam tracking is not an approximate solution but an ideal solution in three-dimensional scanning. A set of tracking mirrors that are attached at the middle of a tube scanner steers a laser beam to a probe and to a detector during scanning. Tracking errors achieved were 2 and 7 nm in horizontal and vertical direction scans over 50 μm scanning. A simple theoretical error estimate revealed that less than 2 nm error is obtainable with moderate mirror mounting accuracy. To reduce the thickness of the scanner for coaxial optical microscope observation, the tube scanner was arranged sideways, resulting in 12 mm scanner thickness. A twist probe, pointed in the vertical direction to enter its tip into a narrow trench, was used for the probe. This system could obtain a semiconductor trench image successfully.
[New ultra-short-acting beta-blockers: landiolol and esmolol--the effects on cardiovascular system]. (2006)

Esmolol and landiolol are ultra-short-acting intravenous beta-blockers. Both drugs have high cardioselectivity (beta1/beta2 selectivity of esmolol : 33, landiolol: 255) and short elimination half time (esmolol : 9 min, landiolol : 4 min). Since the duration of beta-adrenergic blockade is short and cardioselectivity is high compared with traditional intravenous beta-blocker propranolol, both drugs are titrated easily. Its use is particularly suited to critically ill patient and for perioperative period. In clinical settings, both drugs have been used for prevention of perioperative tachycardia after endotracheal intubation or surgical incision and treatment of supuraventricular arrhythmias. Esmolol also has been used for treatment of perioperative hypertension and for reducing cardiac work in patients with ischemic heart disease. Recently, it was reported that prophylactic administration of esmolol may prevent perioperative myocardial ischemia in high risk group. Landiolol is a newer drug compared with esmolol. There are not many clinical trials on landiolol. However, since landiolol has higher cardioselectivity and tends to have less cardiodepressant effect than esmolol, clinical indication of landiolol may be extended. Additional data from large studies are required to evaluate the clinical efficacy and safety of landiolol for a variety of diseases.
Production planning and control tools (2000)

There are numerous tools available to be used for production planning and control purposes. The number of tools is ever increasing, and so are the levels of sophistication as well as complexity. For the specific manufacturing firm, the task of selecting the most appropriate set of tools is not trivial. However, in recent years, the understanding of the relationship between tools and manufacturing environments for which they are suitable has increased. The purpose of this paper is to provide an overview of production planning and control tools available today, as well as new trends, issues and ideas. Keywords: Production Planning And ControlPpc ToolsModellingPpc EnvironmentPpc System
Performance Characteristics and Evaluation of an Automated-Developed and Quantitative, Immunochemical, Fecal Occult Blood Screening Test (2005)

Desktop, automated-developed, quantitative I-FOBT is now available. Refrigerated OC-Sensor samples are stable for 21 days, easy to prepare and develop and, at the 100 ng Hb/mL threshold, have high sensitivity, specificity, and negative predictive values for significant neoplasia. Suitability for population CRC screening awaits further evaluation.
A Psychological Analysis on Challenge for Improvement of Spoken English Competence (2006)

Many, as English foreign language (EFL) learners, psycholinguistically confront with unmanageable tongue-tied situation when combat spoken English (SE), consider that the most difficult competence to acquire what are related to all EFL aspects is SE. In fact, the biggest problem as EFL learners, for instance the non-natives, are aware of learning SE, fall in some specific psychological factors of cognizance. This paper fundamentally presents a challenge for EFL learners of all walks to cope with their psychological incompetence in SE learning so as to help them find some extricable approaches to precipitate the incorrigible obstruction in SE institutionalization.
SHORTER NOTICES (1995)

Journal Article SHORTER NOTICES Get access D. W. SPRING D. W. SPRING University of Nottingham Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CX, Issue 438, September 1995, Pages 1025-b–1026, https://doi.org/10.1093/ehr/CX.438.1025-b Published: 01 September 1995
Design principles for authoring dynamic, reusable learning objects (2003)

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>The aim of this paper is to delineate a coherent framework for the authoring of re-purposable learning objects. The approach is orthogonal to the considerable work into learning object metadata and packaging conducted by bodies such as IMS, ADL and the IEEE. The 'learning objects' and standardisation work has been driven largely by adding packaging and metadata to pre-constructed learning artefacts. This work is very valuable. The argument of this paper, however, is that these developments must be supplemented by significant changes in the creation of learning objects. The principal aim of this paper is to delineate authoring principles for reuse and repurposing. The principles are based on a synthesis of ideas from pedagogy and software engineering. These principles are outlined and illustrated from a case study in the area of learning to program in Java.</span></p></div></div></div>
Review of the Merits in Class Action Certification (2004)

In Eisen v. Carlisle & Jacquelin, the Supreme Court declared that federal courts may not conduct a preliminary inquiry into the merits of a suit in order to determine whether it may be maintained as a class action. This proscription - sometimes known as the Eisen rule - has become a pillar of class action practice, both under Federal Rule of Civil Procedure 23 and under state-court class action procedures. The rule can have a crucial influence on whether a case is certified as a class action - and, given the importance of certification, on the success or failure of the litigation. This Article analyzes the proper scope of a court's inquiry into merits issues when ruling on motions to certify a class. Part I of the Article distinguishes three approaches to this question: strong-form rules that prohibit inquiries into the merits and require the court to accept as true the well-pleaded allegations in the complaint; weak-form rules that permit reasonable inquiries into the merits as relevant to certification and usually place burdens of production and persuasion on the plaintiff; and super-weak rules which permit or require the court to investigate the class's chances of success in the litigation and place burdens of production and persuasion on the plaintiff. Parts II-VI compare these rules with respect to the values of fidelity to law, accuracy in adjudication, fairness in judgments, fairness in settlements, and judicial economy. Part VII argues that weak-form rules are superior to the alternative approaches.
344. Polynuclear heterocyclic systems. Part V. 5 : 8-Diazapentaphene (1952)

G. M. Badger and R. Pettit, J. Chem. Soc., 1952, 1874 DOI: 10.1039/JR9520001874
Extending the Field of Application of Structural Glass Design Concepts (2006)

Keywords: 552/ICOM Note: CD-Rom Reference ICOM-CONF-2006-003 Record created on 2008-01-24, modified on 2016-08-08
Fillers for the improvement in acne scars (2015)

Acne is a common inflammatory disease. Scarring is an unwanted end point of acne. Both atrophic and hypertrophic scar types occur. Soft-tissue augmentation aims to improve atrophic scars. In this review, we will focus on the use of dermal fillers for acne scar improvement. Therefore, various filler types are characterized, and available data on their use in acne scar improvement are analyzed.
Using BP Neural Network to Predict the Molar Volume of SCF-CO2 (2003)

BP Neural Network was used to predict the molar volume of supercritical Carbon Dioxide. In the range of 1.017≤pr≤8.134 and 1.019≤Tr≤5.917,798 experiment points were trained and predicted. The average relative error of predicting is 2.01%. Then RK EOS,RKS EOS and PR EOS are used to calculate these data,with average relative deviations being 2.66% ,3.24% and 2. 48% respectively. This method is proved to be superior to EOS.
Model for bacterial culture growth rate throughout the entire biokinetic temperature range (1983)

The "square-root" relationship proposed by Ratkowsky et al. (J. Bacteriol. 149:1-5, 1982) for modeling the growth rate of bacteria below the optimum growth temperature was extended to cover the full biokinetic temperature range. Two of the four parameters of this new nonlinear regression model represent minimum and maximum temperature bounds, respectively, for the predicted growth of the culture. The new model is easy to fit and has other desirable statistical properties. For example, the least-squares estimators of the parameters of the model were almost unbiased and normally distributed. The model applied without exception to all bacterial cultures for which we were able to obtain data. Results for 30 strains are reported.