gebhart/patrepeval huggingface dataset:
A Case of Adenocarcinoma of the Lung which Was Successfully Treated by Chemotherapy with Patient Survival without Recurrence for More Than Three Years (1987)

A 63-year-old man was admitted to the National Cancer Center Hospital on December 20, 1983 for a close examination of the abnormal shadows found in chest roentgenograms. Chest radiographs showed a massive right pleural effusion, a large tumor in the right hilar region and swelling of the left hilar nodes. Transcutaneous needle biopsy revealed the tumor's cytological type to be adenocarcinoma. The clinical stage was considered to be T3N2M1 (American joint committee (AJC) stage III M1), and his performance status was 4, so he was given etoposide (VP-16) alone as the initial chemotherapy treatment. He showed a partial response upon two courses of VP-16 therapy. Subsequently, one course of cisplatin (80 mg/m2) + vindesine (3.3 mg/m2), two courses of VP-16 (80 mg/m2 D1-4), five courses of cyclophosphamide (80 mg/m2) + adriamycin (50 mg/m2) + vincristine (1.4 mg/m2) and two courses of VP-16 (100 mg/m2 D1, 3, 5) were administered sequentially until May 31, 1985. No radiation therapy was given and, up to March 31, 1987, no sign of recurrence had been observed.
PD20-02 CHRONIC PROSTATE INFLAMMATION PREDICTS SYMPTOM PROGRESSION IN CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN PATIENTS (2016)

Recent studies reported that low total testosterone (T) level is related to the presence of lower urinary tract symptom (LUTS). Because low T is related to LUTS which suggest increase in prostatic urethra pressure and because increase in prostatic urethra pressure is possible cause of chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS), the relationship between T and CP/CPPS would be inferred. Therefore, we evaluated their relationship.
A Study of the Equitransference Level of Concentrated Aqueous RbBr, RbI and NH<sub>4</sub>I, and their Characterization as Ultra‐Concentrated Salt Bridges for the Minimization of Liquid Junction Potentials (1993)

Abstract Ion and solvent transference numbers for aqueous RbBr, RbI and NH 4 I solutions have been determined at molalities up to 5.5, 6.5 and 7.5mol·kg −1 , respectively, from e.m,f. measurements on appropriate transference cells. The results demonstrate that, for the minimization of liquid junction potentials, all the three salts above are better “salt bridges” than the popular saturated‐KCl one, both because they are more nearly equitransferent (over the whole molality range) and because they can reach saturation molalities (7.01, 7.38 and 12.69 mol·kg −1 , respectively, at 25°C) much higher than that of KCl (4.804 mol·kg −1 ). Therefore, concentrated RbBr, RbI and NH 4 I solutions can be recommended as advantageous salt bridges for replacement of the KCl one.
In vitro metabolism of rumenic acid in bovine liver slices (2005)

Ruminant products are the major source of CLA for humans. However, during periods of fat mobilization, the liver might play an important role in CLA metabolism which would limit the availability of the latter for muscles and milk. In this context, rumenic acid (cis-9, trans-11 CLA) metabolism in the bovine liver (n = 5) was compared to that of oleic acid (n = 3) by using the in vitro liver slice method. Liver slices were incubated for 17 h in a medium containing 0.75 mM of FA mixture and 55 microM of either [1-(14)C] rumenic acid or [1-(14)C] oleic acid at 37 degrees C under an atmosphere of 95% O(2)-5% CO(2). Rumenic acid uptake by liver slices was twice (P = 0.009) that of oleic acid. Hepatic oxidation of both FA (> 50% of incorporated FA) led essentially to the production of acid-soluble products and to a lower extent to CO(2) production. Rumenic acid was partly converted (> 12% of incorporated rumenic acid) into conjugated C18:3. CLA and its conjugated derivatives were mainly esterified into polar lipids (71.7%), whereas oleic acid was preferentially esterified into neutral lipids (59.8%). Rumenic acid secretion as part of VLDL particles was very low and was one-fourth lower than that of oleic acid. In conclusion, rumenic acid was highly metabolized by bovine hepatocytes, especially by the oxidation pathway and by its conversion into conjugated C18:3 for which the biological properties need to be elucidated.
Zur Synthese seitenkettenhydroxylierter Tetrahydrocannabinol / Synthesis of Side Chain Hydroxylated Tetrahydrocannabinols (1978)

Abstract The potential ⊿ 8 -tetrahydrocannabinol meta-bolites (6a, b) were synthesized starting from (+)-trans-p-menthadien-(2,8)ol(1) (2) and the resorcyl-alkyl esters (3a, b).
Biodistribution of 111In-DTPA-D-Phe1-octreotide in tumour-bearing nude mice: Influence of injected amount and administration route (2000)

s: Abstracts of an International Conference on Peptide Radiopharmaceuticals in Diagnosis and Therapy Rome, Italy, 25-28 May 2000: Poster Presentations
Epithelial to Mesenchymal Transition Is Activated in Metastatic Pheochromocytomas and Paragangliomas Caused by SDHB Gene Mutations (2012)

We have identified the first pathway that distinguishes SDHB-metastatic from all other types of pheochromocytomas/paragangliomas and suggest that activation of the EMT process might play a critical role in the particularly invasive phenotype of this group of tumors.
Isolation of Lactococcus lactis subsp. cremoris from nature by colony hybridization with rRNA probes (1993)

Lactococcus lactis subsp. cremoris is widely used in the manufacture of fermented milk products. Despite numerous attempts, efforts to isolate new strains by traditional plating and identification methods have not been successful. Previously, we described oligonucleotide probes for 16S rRNAs which could be used to discriminate L. lactis subsp. cremoris from related strains. These probes were used in colony hybridization experiments to screen large numbers of colonies obtained from enrichment cultures. A total of 170 strains of L. lactis were isolated from six milk samples, two colostrum samples, and one corn sample by using oligonucleotide probe 212RLa specific for the species L. lactis. Fifty-nine of these isolates also hybridized to L. lactis subsp. cremoris-specific probe 68RCa, and 26 of the strains which hybridized to the L. lactis subsp. cremoris-specific probe had the L. lactis subsp. cremoris phenotype.
Study of free-piston Stirling engine driven linear alternators (1987)

The analysis, design and operation of single phase, single slot tubular permanent magnet linear alternator is presented. Included is the no-load and on-load magnetic field investigation, permanent magnet's leakage field analysis, parameter identification, design guidelines and an optimal design of a permanent magnet linear alternator. For analysis of the magnetic field, a simplified magnetic circuit is utilized. The analysis accounts for saturation, leakage and armature reaction.
The preservation of ancient DNA and Bone Diagenesis (1997)

info:eu-repo/semantics/published
Combustion of Methane over Palladium-Based Catalysts: Support Interactions (2012)

Palladium-based catalysts are attractive for methane combustion at low temperatures, although deactivation is an issue, making it important to understand the mechanism for the catalytic combustion reaction. Support effects on the catalytic combustion reaction were investigated at temperatures below 450 °C using continuous flow of CH4 plus 16O2 or 18O2 over various combinations of isotopically labeled PdO/metal oxide catalysts. Our experimental results are consistent with a PdO/Pd redox combustion mechanism. However, the oxide supports are also shown to provide oxygen for the catalytic combustion reaction. Pd/PdO serves as a porthole for gas phase oxygen to dissociate, migrate to the oxide support, and exchange with oxygen from the oxide support. The migration and exchange process allows oxygen that was originally bonded to the support to participate in the catalytic combustion reaction. Water, a reaction product, inhibits the exchange of oxygen between the support and PdO. The rate of oxygen exchange is temperature and support dependent. Mechanisms for the low temperature combustion of methane over PdO-based catalysts need to include steps for oxygen and hydroxyl exchange between the Pd phase and the support.
A Refraction Statics Method for Mapping Bedrock (1994)

Abstract The bedrock surface beneath unconsolidated eolian sand and garbage at the active Casper, Wyoming landfill was successfully imaged using a refraction statics method. The method employed the summation of common‐detector refraction seismic traces in a manner analogous to common midpoint (CMP) reflection seismic methods. The method produces a seismic time section that is interpreted in much the same way as reflection seismic time sections. The method was very robust in imaging the bedrock surface, even when the refractions were poorly defined on both unprocessed and filtered shot records. Processing of a refraction statics data set is less expensive than CMP high‐resultion reflection processing and does not rely on the detailed graphical constructs of the more commonly used refraction seismic analysis methods. This alternative to more commonly used refraction and reflection seismic methods should be applicable in noisy and otherwise difficult data acquisition areas where the resolution of first breaks and/or reflections is difficult. The summation of data traces enhances the signal to noise ratio allowing direct observation of the bedrock image on the time section. A depth section can be calculated from the final time section. In poor data quality settings, the enhancement of the refraction signal by summation of multiple, common‐detector data traces is the significant advantage of the refraction statics method over other refraction seismic interpretation methods which are dependent on accurately picking refracted arrivals on individual data traces. An ICP‐MS, equipped with an ultrasonic nebulizer and active‐film multiplier detector, is used to attempt to determine 54 trace elements directly in ground water. Lithium, arsenic, rubidium, strontium, barium, and antimony are found in the microgram‐per‐liter (part‐per‐billion = ppb) range. Most of the other elements are present at nanogram‐per‐liter (part‐per‐trillion = ppt) concentrations. Ion exchange preconcentration is utilized in order to improve the sensitivity for measuring the rare earth elements that exist at concentrations as low as 0.05 ppt for lutetium, thulium, and terbium. The formation of molecular species in the plasma produces false positive results for some of the elements. The presence of silicon or carbon dioxide interferes with the measurement of scandium, strontium interferes with rhodium and palladium, and barium interferes with europium. Correction procedures for these interferences are discussed. All together, the concentrations of the 54 elements in water from four Nevada springs span almost seven orders of magnitude.
Characterization of long‐term stability of hydrophilized PEG‐grafted PDMS within different media for biotechnological and pharmaceutical applications (2011)

Abstract Poly(dimethylsiloxane) (PDMS) is broadly utilized for the development of disposable lab‐on‐a‐chip systems. For many microfluidic applications hydrophilic surface characteristics are indispensable. In this work, an easy, reliable and stable surface hydrophilization procedure based on poly(ethylene glycol) (PEG)‐silanization is presented that overcomes the hydrophobic nature of PDMS. Furthermore, the long‐term stability of the grafting as well as the effect of different parameters ( e.g ., applied solvent) on the hydrophilicity according to the measured contact angles (CAs) are analyzed within different media. Finally, the successful hydrophilization of different PDMS microfluidic devices and the effect of its performance are demonstrated ( e.g ., in a micro‐emulsification component). magnified image Effect of the surface properties of PDMS‐structured devices on the performance of drop emulsification with regard to the CA: (a) bare, hydrophobic and (b) PEG‐grafted, hydrophilic PDMS.
Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways (2009)

White adipose tissue is intimately involved in the regulation of immunity and inflammation. We reported that human mesenteric preadipocytes express the substance P (SP)-mediated neurokinin-1 receptor (NK-1R), which signals proinflammatory responses. Here we tested the hypothesis that SP promotes proliferation and survival of human mesenteric preadipocytes and investigated responsible mechanism(s). Preadipocytes were isolated from mesenteric fat biopsies during gastric bypass surgery. Proliferative and antiapoptotic responses were delineated in 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS), bromodeoxyuridine (BrdU), caspase-3, and TUNEL assays, as well as Western immunoanalysis. SP (10(-7) M) increased MTS and proliferation (BrdU) and time dependently (15-30 min) induced Akt, EGF receptor, IGF receptor, integrin alphaVbeta3, phosphatidylinositol 3-kinase, and PKC-theta phosphorylation. Furthermore, pharmacological antagonism of Akt and PKC-theta activation significantly attenuated SP-induced preadipocyte proliferation. Exposure of preadipocytes to the proapoptotic Fas ligand (FasL, 100 microM) resulted in nuclear DNA fragmentation (TUNEL assay), as well as increased cleaved poly (ADP-ribose) polymerase, cleaved caspase-7, and caspase-3 expression. Cotreatment with SP almost completely abolished these responses in a NK-1R-dependent fashion. SP (10(-7) M) also time dependently stimulated expression 4E binding protein 1 and phosphorylation of p70 S6 kinase, which increased protein translation efficiency. SP increases preadipocyte viability, reduces apoptosis, and stimulates proliferation, possibly via cell cycle upregulation and increased protein translation efficiency. SP-induced proliferative and antiapoptotic pathways in fat depots may contribute to development of the creeping fat and inflammation characteristic of Crohn's disease.
A New Type of Telescope Flow Control-The Unclosure (1991)

A novel approach to the control of the flow past a terrestrial telescope is explored in water tunnel experiments. Instead of a conventional enclosure around the instrument to decelerate the wind, only a bluff body just downstream of the telescope is proposed. A central issue is the separation of the ground plane boundary layer induced by the bluff body. In these tests, streams of dye were injected near the ground plane of the bluff body, a flat plate perpendicular to the ground plane. As a function of the gap between the bluff body and the ground plane, the maximum growth of the upstream boundary layer was measured. The results demonstrate that for both laminar and turbulent boundary layers only modest gaps are necessary to prevent undesirable boundary layer separation, so that the telescope need not be mounted very high to rest above the boundary layer air.
The processing of wheat bran to release bound phenolic compounds improves insulin resistance and reduces visceral adiposity and liver cholesterol in ZDF rat (2011)

Wheat bran (WB) is a rich source of potentially bioactive phenolic compounds but which are largely unavailable. The aim of this study was to examine how consumption of WB processed to release bound phenolics alters metabolic parameters related to diabetes in a model of type 2 diabetes with obesity, the Zucker diabetic fatty (ZDF) rat. WB was processed with chemical treatment and high pressure homogenization to produce an optimized WB (OWB), which was further processed into soluble and insoluble fractions by physical separation. Male ZDF rats (n=10) were fed diets containing either a WB-free basal diet or WB-containing diets (16.4% WB, 22.9% OWB, 27% soluble fraction or 14.1% insoluble fraction) for 3 weeks. The OWB and soluble fraction diets decreased epididymal fat pad weight and increased plasma adiponectin level relative to the WB diet. Insulin resistance (IR) was improved by all processed WB diets. All WB-containing diets decreased plasma insulin and plasma and liver cholesterol and increased bile acid excretion compared to the basal diet. However, OWB and soluble fraction diets improved IR, decreased plasma insulin and liver cholesterol, and increased bile acid excretion compared to the WB diet. These results suggest that processing of WB led to greater phenolic bioavailability which improved the diabetic condition by decreasing IR, visceral adiposity, and liver cholesterol in ZDF rat. Grant Funding Source: USDA
Außerschulische Jugendbildung (2009)

Wenn man an Bildungsprozesse im Kindes- und Jugendalter denkt, fiel einem — zumindest im deutschsprachigen Raum — bis vor kurzem als erstes die Schule ein. Das hat sich in den letzten Jahren erheblich geändert. Verantwortlich dafür waren vor allem auf der einen Seite der 12. Kinder- und Jugendbericht der Bundesregierung (vgl. Deutscher Bundestag 2005) und — zumindest im Ansatz, indem er den Blick auch auf nonformale Lernwelten im Schulalter lenkte — der im Auftrag der Ständigen Kulturministerkonferenz der Länder und dem Bundesministerium für Bildung und Forschung durchgeführte Bericht „Bildung in Deutschland“ (vgl. Konsortium Bildungsberichterstattung 2006, S. 47ff.). Beide Berichte erweiterten das bislang weitgehend auf die Schule konzentrierte Verständnis, wenn von Bildungsprozessen im Kindesund Jugendalter die Rede war, indem sie einerseits die Bedeutung der vorschulischen Bildung betonten, andererseits die Vielfalt der Bildungsorte und der Formen der Bildung außerhalb der Schule zum Thema machten.
PDGF Synergistically Enhances IFN-γ-Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV Dementia (2007)

There is increasing cumulative evidence that activated mononuclear phagocytes (macrophages/microglia) releasing inflammatory mediators in the CNS are a better correlate of HIV-associated dementia (HAD) than the actual viral load in the brain. Earlier studies on simian HIV/rhesus macaque model of NeuroAIDS confirmed that pathological changes in brains of macaques with encephalitis were associated with up-regulation of platelet-derived growth factor (PDGF) and the chemokine, CXCL10. Because the complex interplay of inflammatory mediators released by macrophages often leads to the induction of neurotoxins in HAD, we hypothesized that PDGF could interact with IFN-gamma to modulate the expression of CXCL10 in these primary virus target cells. Although PDGF alone had no effect on the induction of CXCL10 in human macrophages, in conjunction with IFN-gamma, it significantly augmented the expression of CXCL10 RNA & protein through transcriptional and posttranscriptional mechanisms. Signaling molecules, such as JAK and STATs, PI3K, MAPK, and NF-kappaB were found to play a role in the synergistic induction of CXCL10. Furthermore, PDGF via its activation of p38 MAPK was able to increase the stability of IFN-gamma-induced CXCL10 mRNA. Understanding the mechanisms involved in the synergistic up-regulation of CXCL10 could aid in the development of therapeutic modalities for HAD.
Online Implementation of a Short-Term Traffic Prediction Model (2002)

One of the key elements for an effective ATMIS is the ability to predict traffic conditions with reasonable accuracy such that transportation system users are able to make better travel decisions. This study evaluates and implements a traffic prediction model on I-4. The performance is evaluated against different prediction horizons and traffic conditions. The algorithm was also used to support the implementation of an online traffic prediction system that provides the freeway travelers with predicted travel times and delays along the freeway corridor.
SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells (2012)

LSH, a protein related to the SNF2 family of chromatin-remodelling ATPases, is essential for the correct establishment of DNA methylation levels and patterns in plants and mammalian cells. However, some of the phenotypes resulting from LSH deficiency cannot be explained easily by defects in DNA methylation. Here we show that LSH-deficient mouse and human fibroblasts show reduced viability after exposure to ionizing radiation and repair DNA double-strand breaks less efficiently than wild-type cells. A more detailed characterisation of this phenotype revealed that, in the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage. This results in impaired recruitment of MDC1 and 53BP1 proteins to DNA double-strand breaks and compromises phosphorylation of checkpoint kinase CHK2. Furthermore, we demonstrate that the ability of LSH to hydrolyse ATP is necessary for efficient phosphorylation of H2AX at DNA double-strand breaks and successful repair of DNA damage. Taken together, our data reveal a previously unsuspected role of LSH ATPase in the maintenance of genome stability in mammalian somatic cells, which is independent of its function in de novo DNA methylation during development.
Identification and energy calibration of hadronically decaying tau leptons with the ATLAS experiment in pp collisions at $$\sqrt{s}=8$$ s = 8 $$\,\hbox {TeV}$$ TeV (2015)

This paper describes the trigger and offline reconstruction, identification and energy calibration algorithms for hadronic decays of tau leptons employed for the data collected from <i>pp</i> collisions in 2012 with the ATLAS detector at the LHC center-of-mass energy [Formula: see text] [Formula: see text]. The performance of these algorithms is measured in most cases with [Formula: see text] decays to tau leptons using the full 2012 dataset, corresponding to an integrated luminosity of 20.3 fb[Formula: see text]. An uncertainty on the offline reconstructed tau energy scale of 2-4 %, depending on transverse energy and pseudorapidity, is achieved using two independent methods. The offline tau identification efficiency is measured with a precision of 2.5 % for hadronically decaying tau leptons with one associated track, and of 4 % for the case of three associated tracks, inclusive in pseudorapidity and for a visible transverse energy greater than 20 [Formula: see text]. For hadronic tau lepton decays selected by offline algorithms, the tau trigger identification efficiency is measured with a precision of 2-8 %, depending on the transverse energy. The performance of the tau algorithms, both offline and at the trigger level, is found to be stable with respect to the number of concurrent proton-proton interactions and has supported a variety of physics results using hadronically decaying tau leptons at ATLAS.
Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform (2013)

S-prenylation is an important lipid modification that targets proteins to membranes for cell signaling and vesicle trafficking in eukaryotes. As S-prenylated proteins are often key effectors for oncogenesis, congenital disorders, and microbial pathogenesis, robust proteomic methods are still needed to biochemically characterize these lipidated proteins in specific cell types and disease states. Here, we report that bioorthogonal proteomics of macrophages with an improved alkyne-isoprenoid chemical reporter enables large-scale profiling of prenylated proteins, as well as the discovery of unannotated lipidated proteins such as isoform-specific S-farnesylation of zinc-finger antiviral protein (ZAP). Notably, S-farnesylation was crucial for targeting the long-isoform of ZAP (ZAPL/PARP-13.1/zc3hav1) to endolysosomes and enhancing the antiviral activity of this immune effector. These studies demonstrate the utility of isoprenoid chemical reporters for proteomic analysis of prenylated proteins and reveal a role for protein prenylation in host defense against viral infections.