gebhart/patrepeval huggingface dataset:
Acylation vs. Conjugate Addition of Dipotassio β-Diketones with Cinnamic Esters. Synthesis of Unsaturated 1,3,5-Triketones and t-Butyl 5,7-Dioxoalkanoates<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcylation vs. Conjugate Addition of Dipotassio β-Diketones with Cinnamic Esters. Synthesis of Unsaturated 1,3,5-Triketones and t-Butyl 5,7-Dioxoalkanoates1Fred B. Kirby, Thomas M. Harris, and Charles R. HauserCite this: J. Org. Chem. 1963, 28, 9, 2266–2271Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://pubs.acs.org/doi/10.1021/jo01044a027https://doi.org/10.1021/jo01044a027research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ground Moving Target Detection and Imaging Using a Virtual Multichannel Scheme in HRWS Mode (2016)

Along-track multichannel synthetic aperture radar is usually used to achieve ground moving target detection and imaging. Nevertheless, there is a design dilemma between azimuth high resolution and wide swath (HRWS). To solve this problem in HRWS mode, we introduce a virtual multichannel (VMC) scheme. For each virtual channel, the low real pulse repetition frequency (PRF) improves the ability of resolving range ambiguity for wide-swath, and the high virtual PRF improves the capability of resolving Doppler ambiguity for azimuth high resolution. For multiple virtual channels, strong ground clutter is eliminated by the joint VMC processing. Furthermore, a detailed signal model of a moving target in the virtual channel is given, and the special false-peak effect in the azimuthal image is analyzed. Moreover, we propose a novel ground moving target processing method based on the VMC scheme and the clutter suppression interferometry (CSI) technique, which is called VMC-CSI. The integration of detection, location, velocity estimation, and imaging for ground moving targets can be achieved. Accounting for the unresolved main peak and false peak for a moving target, in the VMC-CSI method, we adopt a two-step scheme to estimate the radial velocity and along-track velocity, namely, rough estimation and precise estimation. Meanwhile, considering the same interferometric phases of the main peak and the false peak, we use false peaks first for the robustness of initial azimuth location estimation and remove false peaks afterward. Numerical simulations are provided for testing the effect of the false peak and the effectiveness of VMC-CSI.
Current sunscreen controversies: a critical review (2011)

Given the established benefits of UV protection, the use of sunscreens remains an important part of an overall photoprotective strategy. Future sunscreens with improved formulation should ideally offer superior protection. With increased usage of sunscreen by the public, continuous and vigilant monitoring of the overall safety of future products is also needed.
Characterization of 3G Data-Plane Traffic and Application towards Centralized Control and Management for Software Defined Networking (2013)

With the wide deployment of 3G/4G cellular data networks there is a tremendous growth of mobile Internet access worldwide. We conduct a detailed measurement study about user behaviors, application usage and location patterns of users. We present a methodology that correlates different network attributes and user information together. For user behaviors we classify all users into four groups by time division and investigate the behaviors of different types of users. For example, we find that midnight users consume tremendous network bandwidth. We categorize applications into several groups and provide insights of each type of application usage about up/down flow user numbers and user request times. We also analyze the location information of users that reveal the relationship between network usages with user mobility. Our study successfully provides network operational insights with the details of network usage or the user remarkable behaviors that can help network planners and operators to plan and adaptively adjust network capacity assignment and flow or application management. Most importantly it will help service providers to reduce their operating cost and offer more flexible and variety of services to meet the needs of today's mobile clients without the need of increasing capacity in congested areas. Finally, our analysis will enable much more efficient routing and resource allocation management applications in the recent endeavor for software defined networking that will put such responsibility into the logically centralized controllers.
Computing the Most Significant Solution from Pareto Front obtained in Multi-objective Evolutionary (2010)

Problems with multiple objectives can be solved by using Pareto optimization techniques in evolutionary multi-objective optimization algorithms. Many applications involve multiple objective functions and the Pareto front may contain a very large number of points. Selecting a solution from such a large set is potentially intractable for a decision maker. Previous approaches to this problem aimed to find a representative subset of the solution set. Clustering techniques can be used to organize and classify the solutions. Implementation of this methodology for various applications and in a decision support system is also discussed.
A Multi-Agent Fault Detection System for Wind Turbine Defect Recognition and Diagnosis (2007)

This paper describes the use of a combination of anomaly detection and data-trending techniques encapsulated in a multi-agent framework for the development of a fault detection system for wind turbines. Its purpose is to provide early error or degradation detection and diagnosis for the internal mechanical components of the turbine with the aim of minimising overall maintenance costs for wind farm owners. The software is to be distributed and run partly on an embedded microprocessor mounted physically on the turbine and on a PC offsite. The software will corroborate events detected from the data sources on both platforms and provide information regarding incipient faults to the user through a convenient and easy to use interface.
Update on Phase I Studies in Advanced Pancreatic Adenocarcinoma. Hunting in Darkness? (2013)

Over the last twenty years, there is a limited number of effective cytotoxic or biological agents that managed to get approval in advanced pancreatic ductal adenocarcinoma. Despite numerous trials, investments in translational research and generally in health care, the survival of pancreatic cancer patients has improved by a few only months. This disappointing reality necessitates a better understanding of the pathogenesis of this disease and the identification of targetable alterations which might lead to development of more effective drugs or better combinations. At the 2013 Annual Meeting of the American Society of Clinical Oncology, few novel agents and new therapeutic concepts, tested in phase I studies in advanced pancreatic ductal adenocarcinoma, were presented. The first notable phase I study referred to the combination of chemotherapy with local delivery of silencing RNA against the K-ras mutation G12D, in advanced pancreatic ductal adenocarcinoma, which was well tolerated and promising (Abstract #4037). The second one referred to a combination of gemcitabine with pegylated recombinant human hyaluronidase (PEGPH20), an inhibitor of hyaluronan which as a matrix glycosaminoglycan is believed to play role in the reduced drug delivery to cancer (Abstract #4010). The other notable abstract was related to an early phase study which tested the safety and toxicity of arctigenin, a traditional herbal agent found in Arctium lappa Linné, administered as an oral formulation (GMS-01) in pancreatic ductal adenocarcinoma patient resistant to standard chemotherapy (Abstract #2559). The aforementioned early phase studies open new therapeutic approaches which deserve further testing in advanced pancreatic cancer.
Messiaen and Cocteau (2017)

I didn’t approve at all of the movement led by Cocteau – I’m not speaking of Cocteau the poet or film director, but of the Cocteau of Coq et l’arlequin, the torchbearer of a certain musical renewal, supposedly a simplification that took Gounod as a starting point and stumbled in the ‘return to Bach’.
Experimental exposure to propylene glycol mist in aviation emergency training: acute ocular and respiratory effects (2001)

Short exposure to PG mist from artificial smoke generators may cause acute ocular and upper airway irritation in non-asthmatic subjects. A few may also react with cough and slight airway obstruction.
Microelectromechanical systems–based visible-near infrared Fabry-Perot tunable filters using quartz substrate (2012)

There is a need to develop miniature optical tunable filters for small hyperspectral imagers. We plan to develop a number of miniature Fabry-Perot tunable filters (FPTFs) using microelectromechanical systems (MEMS) technology, each operating over a different wavelength region, to cover spectral regions from the visible to the longwave infrared (IR). Use of a MEMS-based FPTF as a dispersive element will reduce the size, weight, and power requirements of hyperspectral imagers and make them less expensive. A key requirement for such a filter is a large optical aperture. Recently, we succeeded in fabricating FPTFs with a 6 mm optical aperture operating in the visible to near IR spectral region (400 to 800 nm) using commercially available thin quartz wafers as the substrate. The FPTF design contains one fixed silver (Ag) mirror and one electrostatically movable Ag mirror, each grown on a quartz substrate with a low total thickness variation. Gold (Au) bumps are used to control the initial air gap distance between the two mirrors, and Au-Au bonding is used to bond the device. We describe material selection, device design, modeling, fabrication, interferometric, and spectral characterizations.
HLA antigens associated with susceptibility to herpes simplex virus infection. (1992)

HLA antigen frequencies in 150 patients with recurrent herpes simplex virus infection and 176 normal Iraqi controls were studied. Highly significant increased frequencies of HLA-A1, -B5 and -DR1 were found in patients as compared to control individuals. The frequencies of HLA-A3 and -A23 were also significantly increased in patients. When we subdivide the patients into groups according to rate of recurrence of symptomatic infection or ELISA reading of antibody titre no preferential association of HLA antigens with any particular subgroup is apparent. These results were compared with published findings for other ethnic populations and found to be compatible with them.
PIPEs (2002)

LBO funds made many risky gambles in PIPEs beginning in 1999, and several prominent firms were badly burned. The depressed prices of many venture-backed public companies have attracted the attention of venture capitalists, but VCs can learn several lessons from the failures in the LBO sector. This article explores those lessons.
A method of coupling the Paternò–Büchi reaction with direct infusion ESI-MS/MS for locating the CC bond in glycerophospholipids (2016)

Tandem mass spectrometry (MS/MS) coupled with soft ionization is established as an essential platform for lipid analysis; however, determining high order structural information, such as the carbon-carbon double bond (C[double bond, length as m-dash]C) location, remains challenging. Recently, our group demonstrated a method for sensitive and confident lipid C[double bond, length as m-dash]C location determination by coupling online the Paternò-Büchi (PB) reaction with nanoelectrospray ionization (nanoESI) and MS/MS. Herein, we aimed to expand the scope of the PB reaction for lipid analysis by enabling the reaction with infusion ESI-MS/MS at much higher flow rates than demonstrated in the nanoESI setup (∼20 nL min(-1)). In the new design, the PB reaction was effected in a fused silica capillary solution transfer line, which also served as a microflow UV reactor, prior to ESI. This setup allowed PB reaction optimization and kinetics studies. Under optimized conditions, a maximum of 50% PB reaction yield could be achieved for a standard glycerophosphocholine (PC) within 6 s of UV exposure over a wide flow rate range (0.1-10 μL min(-1)). A solvent composition of 7 : 3 acetone : H2O (with 1% acid or base modifier) allowed the highest PB yields and good lipid ionization, while lower yields were obtained with an addition of a variety of organic solvents. Radical induced lipid peroxidation was identified to induce undesirable side reactions, which could be effectively suppressed by eliminating trace oxygen in the solution via N2 purge. Finally, the utility of coupling the PB reaction with infusion ESI-MS/MS was demonstrated by analyzing a yeast polar lipid extract where C[double bond, length as m-dash]C bond locations were revealed for 35 glycerophospholipids (GPs).
Design and development of Multi-touchable E-restaurant Management System (2010)

Numerous efforts have been taken by restaurants to adopt information and communication technologies such as touch screen, PDA, wireless LAN etc. to enhance dining experience. This paper highlights some of the limitations of the PDA-based food ordering system and proposed the Multi-touchable E-restaurant Management System as a solution. The system consists of the multi-touchable interactive dining menu that allows customers to make order conveniently on the developed multi-touchable dining table during the busy hours using their fingers. Orders made by the customers will be updated instantly to a centralized database and subsequently reach the cashier and the kitchen module respectively. Management staff could use the system to manage the restaurant operations digitally, starting from the creation of food items for the multi-touchable interactive dining menu to deleting it or to manage orders from customers all the way to billing it. The system was built using Adobe Flash ActionScript 3, PHP scripting and MySQL database on top of Zend Framework.
Tailoring Patent Policy to Specific Industries (2003)

Mr. Burk illustrates that federal courts have diverged along industry-specific paths when deciding patent cases. Burk highlights courts' disparate treatment of the biotechnology and computer software industries within the uniform patent statute. Due to industries' differing requirements for innovation and development, Professor Burk argues that the currently general patent statute and its incentive to innovate may be improved by tailoring it to specific industries. Burk creates a dialogue on what kinds of statutory schemes promote innovation. Citing the Supreme Court's statement in Diamond v. Chakrabarty that the patent statute is meant to cover anything under the sun made by man, Burk explains that courts are responsible for applying the patent statute to all new kinds of technology that Congress could not have fully anticipated when it passed the statute. Burk compares the U.S. approach to that of Canada, where certain new technologies will not be covered by its patent statute unless Parliament affirmatively legislates the matters. Essentially, Burk asks, what statutory scheme best promotes innovation? The author agrees with Chakrabarty in that the judiciary is the best place for this industry-specific tailoring to take place. Courts already use different policy levers in patent law, such as the obviousness and disclosure standards, to tailor to each industry. Professor Burk suggests that courts make more calculated uses of these tools to better promote innovation.
Development of Respirable Aerosol Samplers Using Porous Foams (1998)

Workplace aerosols must be sampled to assess the degree of health hazard caused by the particulate matter. By adjusting the sampling flow rate, most of the samplers can match the 50% cutoff size, but not the slope of the respirable convention defined by the American Conference of Governmental Industrial Hygienists, the International Organization for Standardization, and the European Committee for Standardization (CEN). Combinations of foams (or other porous material) of different nominal sizes (10-100 ppi) and thicknesses (5-35 mm) were employed to overcome this bias. A foam disk 25 mm in diameter was placed in an asbestos sampling cowl. Dioctylphthalate was the liquid test agent. An aerodynamic particle sizer and an Aerosizer were calibrated against a settling chamber and were employed to measure the aerosol number concentrations and size distributions upstream and downstream of the foams. The sampling efficiency data showed that the 50% cutoff size could be met for foams in series, but that the slope remained sharper than the new definition. Foams in parallel showed great flexibility and many of the parallel combinations flattened the slope, closer to that of the new international respirable convention. For instance, when the total flow rate is set at 10.1 L/min the aerosol penetration through foams in parallel (100 ppi, 20 mm thick, diameter 25 mm + 10 ppi, 20 mm thick, diameter 13 mm) nearly matched the new international standard for respirable fraction. This sampler can be further miniaturized for smaller sampling flow rates to fit the capacity of personal sampling pumps.
Severe Environment Testing of Silicon Nitride Rolling Elements. (1979)

Wear rates for dry film lubricated rolling-spinning contacts of silicon nitride surfaces were studied to 540 C wear rate was essentially constant to 315 C. Surface stress modifications in hot pressed silicon nitride have been shown to improve tensile stress behavior under high magnitude Hertzian stress fields. (Author)
Open architecture for contactless smartcard-based portable electronic payment systems (2008)

In this paper, we present a commercial-off-the-shelf (COTS) prototype design for a handheld, contactless, smartcard-based unit for the mass transit and regional rail systems. This project is an extension from two senior design project research efforts in the College of Engineering at Temple University which were focused on developing an open architecture design for the regional rails system of the South Eastern Pennsylvania Transportation Authority (SEPTA). The goal is to develop a non-proprietary and plug-in-and-play multi-modal transport payment (i.e. cash, credit card, passes, and more importantly the contactless smartcard) portable solution for the financially troubled public transit systems in the United States. Our proposed design utilizes an HP iPAQ hx2795 PDA (Personal Digital Assistant) with Bluetooth capability, an EXTECH S2500THS Bluetooth thermal printer/magnetic card reader, and an SDiD 1010 SD-interface contactless smartcard reader. As a result, the conductor will only need to carry the PDA device for ticket transactions; with the EXTECH s2500ths unit attached to the conductor’s belt. The system has been demonstrated with effective applicability, usability and durability for today’s transit systems.
Increased Cerebral Infarct Volumes in Polyglobulic Mice Overexpressing Erythropoietin (2001)

There is increasing evidence that erythropoietin (Epo) has a protective function in cerebral ischemia. When used for treatment, high Epo plasma levels associated with increases in blood viscosity, however, may counteract beneficial effects of Epo in brain ischemia. The authors generated two transgenic mouse lines that overexpress human Epo preferentially, but not exclusively, in neuronal cells. In mouse line tg21, a fourfold increase of Epo protein level was found in brain only, whereas line tg6 showed a dramatic increase of cerebral and systemic transgene expression resulting in hematocrit levels of 80%. Cerebral blood flow (CBF), as determined by bolus tracking magnetic resonance imaging, was not altered in the tg6 line. The time-to-peak interval for the tracer, however, increased approximately threefold in polyglobulic tg6 mice. Immunohistochemical analysis revealed an increase in dilated vessels in tg6 mice, providing an explanation for unaltered CBF in polyglobulic animals. Permanent occlusion of the middle cerebral artery (pMCAO) led to similar perfusion deficits in wild-type, tg6, and tg21 mice. Compared with wild-type controls, infarct volumes were not significantly smaller (22%) in tg21 animals 24 hours after pMCAO, but were 49% enlarged (P < 0.05) in polyglobulic tg6 mice. In the latter animals, elevated numbers of Mac-1 immunoreactive cells in infarcted tissue suggested that leukocyte infiltration contributed to enlarged infarct volume. The current results indicate that moderately increased brain levels of Epo in tg21 transgenic mice were not sufficient to provide significant tissue protection after pMCAO. The results with tg6 mice indicate that systemic chronic treatment with Epo associated with elevated hematocrit might deteriorate outcome after stroke either because of the elevated hematocrit or other chronic effects.
Role of opioid antagonists in treating intravenous cocaine abuse (1989)

Intravenous cocaine abuse is a major probel in opioid abusers including those treated in methadone maintenance. Studying 138 opioid addicts, we found that speedballing by combining opioid agonists with cocaine may be blocked by opioid antagonists such as naltrexone and by partial antagonists such as buprenorphine. With both these treatments cocaine abuse was five to eight times less than with methadone treatment.
Wide-band integrated optical receiver with improved dynamic range using a current switch at the input (1993)

The front end of optical transmission systems usually consists of a low-noise, wide-band, negative-feedback transimpedance or current amplifier. The dynamic range of current amplifiers can be extended considerably by passing large input currents directly to the output of the amplifier. It is shown that the required current switch does not deteriorate the sensitivity of the receiver. A complete front end, using an external p-i-n photodiode, is integrated in a 2.5-GHz bipolar technology. The receiver has a dynamic range (DR) of 73 dB in a bandwidth of 220 MHz and consumes a supply current of 1.5 mA.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>