gebhart/patrepeval huggingface dataset:
Two-Dimensional Assembly of Purines and Pyrimidines on Au(111) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-Dimensional Assembly of Purines and Pyrimidines on Au(111)Thomas Boland and Buddy D. RatnerCite this: Langmuir 1994, 10, 10, 3845–3852Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/la00022a074https://doi.org/10.1021/la00022a074research-articleACS PublicationsRequest reuse permissionsArticle Views440Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Effects of Washing and Drying on the Dimensional Stability of Woven Fabrics with and without Spandex (2017)

There is increased interest in clothes dryers and garments made of spandex-blend woven fabrics; however, there is limited information available for the laundering and drying these clothes. This study investigates the effects of washing and drying on shrinkage, skewness, and wrinkle for woven fabrics with and without spandex. When spandex with good elastic recovery was blended, the deformed shape from washing and drying improved skewness and wrinkle by easily returning to its original shape. However, these properties had a negative effect on shrinkage in terms of length and area change. When the influence of clothes maintenance was classified, the drying process had the biggest influence of 58%, followed by spinning-rinsing-washing. Tumble drying, in which the fabric is exposed to mechanical force and heat for a long period, had more negative effects on the dimensional stability than line drying. The spandex blend had the effect of preventing skewness and wrinkle in garments, but it was also shown to accelerate shrinkage by garment main-tenance cycles. It was important to control drying in order to reduce shrinkage during the maintenance pro-cess; consequently, this had the greatest influence on the dimensional stability of fabrics. Therefore, line dry-ing was more advantageous for spandex-blend fabrics than tumble drying in terms of management for shrin-kage, skewness, and wrinkle.
Synthesis and characterisation of precursors to organometal cluster networks (1995)

Thermolysis of triruthenium dodecacarbonyl in the presence of the appropriate dicyclic ligand C6H5(CH2)nPh in octane afford organometallic clusters with the general formula [Ru6C(CO)14{η6-C6H5(CH2)nPh}]. The molecular structures of the three octahedral cluster compounds (n= 0 1, 1 2 or 2 3) have been established by single-crystal X-ray analysis. In all three the ligand occupies an apical position formally replacing three carbonyl units on a single metal site of [Ru6C(CO)17]. Studies of the 1H NMR spectra of compounds 1–3 have revealed a trend in electronic inductive effects. Thermolysis of [Ru6C(CO)17] in the presence of an excess of transstilbene afforded 3 and trans-[Ru6C(CO)14-{η6-C6H5(CH)2Ph}]4 in good yield.
The Growth Hormone-Releasing Hormone Receptor: Desensitisation Following Short-Term Agonist Exposure* (2001)

We have investigated the effect of short-term preexposure of growth hormone-releasing hormone (GHRH) on the subsequent response to GHRH in a baby hamster kidney (BHK) cell line expressing the human GHRH receptor and in primary rat pituitary cells. In the BHK cells the receptor was rapidly desensitised in a homologous fashion. Preexposure with agents directly stimulating the cAMP pathway like forskolin and db-cAMP had no effect. In rat pituitary cells we also observed a rapid desensitisation of the GHRH response in an apparently homologous fashion. In both systems the desensitisation was dose-dependent with no change in the potency of the hormone in a subsequent stimulation, only the efficacy was decreased. In the rat pituitary cell, the response measured as growth hormone release was more sensitive to the agonist-induced desensitisation than the cAMP response. No indication of depletion of growth hormone (GH) stores was seen. In rat pituitary cells, contrary to observations in BHK cells, preexposure with both forskolin and db-cAMP desensitised a subsequent growth hormone-releasing hormone stimulation, indicating a heterologous desensitisation. Phorbol-12-myristate 13-acetate (PMA), on the other hand, had no effect. In the baby hamster kidney cells it was demonstrated that the GHRH receptor surface expression decreased following preexposure with GHRH. This phenomenon was observed only in whole cells suggesting a rapid internalisation process. Together, these data indicate that after short-term GHRH preexposure, both in a human and rat system, the following GHRH response is desensitised. In BHK cells this desensitisation is strictly homologous. In rat pituitary cells, on the other hand, the desensitisation is a mixed homologous/ heterologous type.
Impaired modulation of sympathetic α‐adrenergic vasoconstriction in contracting forearm muscle of ageing men (2005)

Recent evidence indicates that older healthy humans demonstrate greater vasoconstrictor tone in their active muscles during exercise compared with young adults. Therefore, we tested the hypothesis that the normal ability of muscle contractions to blunt sympathetic alpha-adrenergic vasoconstriction (functional sympatholysis) is impaired with age in healthy humans. We measured forearm blood flow (FBF; Doppler ultrasound) and calculated the forearm vascular conductance (FVC) responses to alpha-adrenergic receptor stimulation during rhythmic handgrip exercise (15% maximum voluntary contraction) and during a control non-exercise vasodilator condition (intra-arterial adenosine infusion) in seven young (25 +/- 2 years) and eight healthy older men (65 +/- 2 year). FVC responses to intra-arterial tyramine (evokes endogenous noradrenaline release), phenylephrine (alpha1-agonist) and clonidine (alpha2-agonist) were assessed. In young men, the vasoconstrictor responses to tyramine (-25 +/- 1 versus -56 +/- 6%), phenylephrine (-11 +/- 4 versus -39 +/- 4%) and clonidine (-12 +/- 4 versus -38 +/- 5%; all P < 0.005) were blunted during exercise compared with adenosine. In contrast, exercise did not significantly blunt the response to tyramine (-30 +/- 2 versus -36 +/- 7%; P = 0.4) or phenylephrine (-16 +/- 2 versus -19 +/- 3%; P = 0.3) in older men, but did attenuate the response to clonidine (-22 +/- 3 versus -37 +/- 6%; P < 0.05). The magnitude of functional sympatholysis, calculated as the difference in the vasoconstrictor responses during adenosine infusion and exercise, was significantly lower in older compared with young men in the presence of tyramine (-6 +/- 7 versus -31 +/- 6%), phenylephrine (-3 +/- 3 versus -28 +/- 4%) and clonidine (-15 +/- 4 versus -26 +/- 3%; all P < 0.05). We conclude that ageing is associated with impaired functional sympatholysis in the vascular beds of contracting forearm muscle in healthy men. These findings might help explain the greater skeletal muscle vasoconstrictor tone and reduced blood flow during large muscle dynamic exercise in older adults.
ChemInform Abstract: Total Synthesis of Isoroquefortine C (I). (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
SSU1 mediates sulphite efflux inSaccharomyces cerevisiae (2000)

Ssu1p, a plasma membrane protein involved in sulphite metabolism in Saccharomyces cerevisiae, was found to be required for efficient sulphite efflux. An SSU1 null mutant accumulated significantly more sulphite than wild-type, whereas cells expressing multicopy SSU1 accumulated significantly less. Cells expressing FZF1-4, a dominant allele of a transcriptional activator of SSU1 that confers sulphite resistance, also accumulated less sulphite. beta-galactosidase activity in the FZF1-4 strain carrying an SSU1::lacZ fusion was found to be 8.5-fold higher than in a strain carrying wild-type FZF1, confirming that the heightened resistance was correlated with hyperactivation of SSU1. Multicopy SSU1 was also found to increase the sulphite resistance of a number of unrelated sulphite-sensitive strains by a factor of 3- to 8-fold. Rates of efflux of free sulphite from cells expressing multicopy SSU1 or FZF1-4 were significantly greater than that from wild-type or from a SSU1 null mutant. Rates of efflux of bound sulphite from wild-type, a SSU1 null mutant, a FZF1-4 mutant, or cells expressing multicopy SSU1 were not significantly different, suggesting that Ssu1p specifically mediates efflux of the free form of sulphite.
DETECTION OF HTLV-I ANTIBODIES AND DNA IN BLOOD SAMPLE OF A PATIENT WITH MYELOPATHY IN NIGERIA (1998)

We describe a case of human T-lymphotropic virus type I associated myelopathy in a 50-year old woman in Nigeria. The patient presented with progressive loss of tone to the two lower limbs and later inability to walk. The HTLV-I antibody presence in the plasma collected from the patient was repeatedly detected by enzyme immunoassays (Abbott HTLV-I EIA and Coulter SELECT-HTLV I/II) and confirmed by Western blot technique. In addition, HTLV-I DNA was amplified from the genomic DNA isolated from the peripheral blood mononuclear cells of the patient by the polymerase chain reaction technique. This finding is significant being the first report of association of HTLV-I with myelopathy in Nigeria.
Extraction of left-ventricular chamber from 3-D CT images of the heart (1990)

A semiautomatic method is described for extracting the volume and shape of the left ventricular (LV) chamber from a dynamic spatial reconstructor cardiac volume. For a given volume, the operator first performs some simple manual edits. Then, an automated stage, which incorporates concepts from 3-D mathematical morphology and technology, the maximum-homogeneity filter, and an adaptive 3-D thresholder, extracts the LV chamber. The method gives more consistent measurements and demands considerably less operator time than manual slice-editing.
Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation (2012)

Cystic fibrosis transmembrane conductance regulator (CFTR) is a unique member of the ATP-binding cassette (ABC) protein superfamily. Unlike most other ABC proteins that function as active transporters, CFTR is an ATP-gated chloride channel. The opening of CFTR's gate is associated with ATP-induced dimerization of its two nucleotide-binding domains (NBD1 and NBD2), whereas gate closure is facilitated by ATP hydrolysis-triggered partial separation of the NBDs. This generally held theme of CFTR gating-a strict coupling between the ATP hydrolysis cycle and the gating cycle-is put to the test by our recent finding of a short-lived, post-hydrolytic state that can bind ATP and reenter the ATP-induced original open state. We accidentally found a mutant CFTR channel that exhibits two distinct open conductance states, the smaller O1 state and the larger O2 state. In the presence of ATP, the transition between the two states follows a preferred O1→O2 order, a telltale sign of a violation of microscopic reversibility, hence demanding an external energy input likely from ATP hydrolysis, as such preferred gating transition was abolished in a hydrolysis-deficient mutant. Interestingly, we also observed a considerable amount of opening events that contain more than one O1→O2 transition, indicating that more than one ATP molecule may be hydrolyzed within an opening burst. We thus conclude a nonintegral stoichiometry between the gating cycle and ATP consumption. Our results lead to a six-state gating model conforming to the classical allosteric mechanism: both NBDs and transmembrane domains hold a certain degree of autonomy, whereas the conformational change in one domain will facilitate the conformational change in the other domain.
Polyimide asymmetric membranes: Elaboration, morphology, and gas permeation performance (2003)

Abstract Asymmetric 2,2‐bis‐(3,4‐dicarboxyphenyl) hexafluoropropane dianhydride (6FDA)‐2‐methyl‐1,3‐phenylenediamine (mPDA) polyimide membranes were prepared according to a phase‐inversion mechanism by using different solvent/nonsolvent blends. The membrane formation mechanism and the final performances of the asymmetric membranes have been found both nonsolvent and solvent nature dependent. From the visualization of cross sections of asymmetric membranes by scanning electron microscopy and the study of the permeation of two gases (N 2 , CO 2 ) through asymmetric membranes, a relationship between elaboration conditions and asymmetric membranes characteristics could be drawn. The organization of polymer chains in solution strongly affects the final polymer arrangement and thus the final performances of the membrane. The influence of preliminary solvent evaporation before immersion has been shown to be dependent on the structure of the asymmetric membrane: finger‐like or sponge‐like structures. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 1838–1848, 2003
Mathematical Simulation of Process Parameters in the case of Rapid Solidification of Steel (2003)

Rapid solidification of steel was investigated experimentally under laboratory conditions by immersion of cold copper rods in steel baths. For a better understanding of the process parameters during rapid solidification, an explicit finite difference model was employed. In the calculation, a coefficient of heat transfer between a frozen steel shell and solid copper of α = 40 [KW/m2·K] is assumed in good agreement with experimental data derived from temperature measurements. The solidification parameters such as local time of solidification (LST), local time of the superheat reduction (LShRT), local solidification and cooling rates (LSR, LCR) and local heat flux density of solidification and superheat reduction (LSHFD, LShRHFD) can be calculated using the developed model, in dependence on the processing conditions. This influence of processing parameters, such as steel bath superheat, steel bath material, immersed body material, initial temperature of immersed body and immersed body geometry, were the subject of intensive investigations.
A New High Capacity Graphite /Silicon Composite Material for Lithium-Ion Batteries (2010)

Abstract not Available.
Simulation and characterization of a high-sensitive micro-opto-mechanical Microphone (2018)

Micro-opto-mechanical Microphone (MOMM) based on integrated optical Mach-Zehnder interferometers (MZI) are promising for future application in medical environments. However, the design of next generation MOMM systems on chip remains challenging due to the intrinsic multi-physics characteristics related to acoustic, mechanical, optical and electrical effects. We therefore developed a methodology composed of acoustic, mechanic, optical, and electronic sections for fast design of high performance MOMM systems. The feasibility has been demonstrated as the operational characteristics of the fabricated MOMM (i.e. resonance frequency, dynamic range, the sensitivity and SNR) align well with the measured references.
Cytochrome P450 mono‐oxygenase‐regulated signalling of Ca2+ entry in human and bovine endothelial cells. (1995)

1. We tested the hypothesis that agonist-stimulated Ca2+ entry, and thus formation of endothelium-derived nitric oxide (EDNO) in vascular endothelial cells, is related to activation of microsomal P450 mono-oxygenase (P450 MO) and the biosynthesis of 5,6-epoxyeicosatrienoic acid (5,6-EET). 2. Several P450 inhibitors diminished the sustained [Ca2+]i plateau response to agonist or intracellular Ca2+ store depletion with ATPase inhibitors by 31-69% (fura-2 technique). Mn2+ influx stimulated by agonists or ATPase inhibitors was prevented by P450 inhibitors. 3. Histamine- or ATPase inhibitor-stimulated formation of EDNO was strongly attenuated (50-83%) by P450 inhibitors, without any effect on EDNO formation by the Ca2+ ionophore A23187, indicating that decreased EDNO synthesis is due specifically to the inhibition of Ca2+ entry by these compounds. 4. Induction of P450 MO by beta-naphthoflavone potentiated agonist-induced Ca2+ and Mn2+ influx by 60 and 53%, respectively. Intracellular Ca2+ release remained unchanged. 5. The P450 MO product, 5,6-EET (< 156 nmol l-1), activated Ca2+/Mn2+ entry without any depletion of intracellular Ca2+ stores. The 5,6-EET-stimulated Ca2+/Mn2+ entry was not affected by P450 inhibitors. 6. As with the bradykinin-stimulated Ca2+ entry pathway, the 5,6-EET-activated Ca2+ entry pathway was permeable to Mn2+ and Ba2+, sensitive to Ni2+, La3+ and membrane depolarization, and insensitive to the removal of extracellular Na+ or the organic Ca2+ antagonist, nitrendipine. 7. In the presence of 5,6-EET, stimulation with bradykinin only transiently increased [Ca2+]i. Vice versa, 5,6-EET failed to increase [Ca2+]i further in bradykinin-stimulated cells. The sustained [Ca2+]i plateau phase induced by a co-stimulation with bradykinin and 5,6-EET was identical to that observed with bradykinin or 5,6-EET alone. 8. These results demonstrate that Ca2+ entry induced by the P450 MO product, 5,6-EET, is indistinguishable to that observed by stimulation with bradykinin. 9. All data support our hypothesis that depletion of endothelial Ca2+ stores activates microsomal P450 MO which in turn synthesizes 5,6-EET. We propose that the arachidonic acid metabolite 5,6-EET or one of its metabolites is a second messenger for activation of endothelial Ca2+ entry.
Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis (2018)

Exercise training, in particular aerobic and combined exercise, improves endothelial function in type 2 diabetes patients, but such an improvement appears to be weakened compared with non-diabetics. Trial registration PROSPERO CRD42018087376.
Disseminated Tumor Cells in Bone Marrow and the Natural Course of Resected Esophageal Cancer (2012)

The presence of DTC in bone marrow is a strong and independent prognostic factor in patients with resectable EC.
Transient Effect of L-5-Hydroxytryptophan on Pituitary Function in Men and Women* (1983)

To further elucidate the role of serotonin in the secretion of pituitary hormones, a loading dose of 0.8 mg/kg for 1 h, following by a maintenance dose of 0.1 mg/kg . h of L-5-hydroxytryptophan (5-HTP) for 23 h were administered iv to five normal men and five normal women. Five additional men received repeated loading doses of 5-HTP 4 and 6 h after the initial one, with or without the maintenance dose. The initial studies demonstrated a significant, but transient, increase in plasma PRL, GH, cortisol (P less than 0.01) and TSH (P less than 0.05) in the five man and a consistent and significant transient increase only in PRL and cortisol in the five women. Plasma LH and FSH values were not affected by 5-HTP administration. The constant administration of 5-HTP revealed a blunting effect on the nocturnal rise of TSH in men. The continuous administration of 5 HTP failed to maintain the rise induced by the loading dose. Individuals receiving additional loading doses of 5-HTP demonstrated a subsequent increase in GH and cortisol, but not in serum PRL. This study suggests that endogenous serotonin may exert its stimulatory effect on pituitary hormone secretion primarily by sporadic release, rather than by continuous secretion.
Sample holder and methodology for measuring the reflectance and transmittance of narrow-leaf samples (2007)

Measuring the reflectance and transmittance of narrow samples can be difficult, as the width of the illuminating beam may be greater than the width of the sample. The small sample area can also compound the already time-consuming process of reconfiguring the instrument between reflectance and transmittance measurements by introducing additional alignment problems. A method of measuring the reflectance and transmittance properties of narrow-leaf samples using reflectance configurations only is developed and tested. The method uses a mask and mask correction and relationships between reflectance measurements against contrasting backgrounds to determine sample reflectance and transmittance. The design of the accompanying sample-holding apparatus is also described. In testing, the mean error was less than 1% reflectance/transmittance, and standard deviation of the error was approximately 1% reflectance and 2% transmittance as compared to samples measured using conventional measurement configurations.
Biochemical Responses of Nano-Pillar Gate Field-Effect Devices (2007)

We have developed biochemical field effect devices with nano-pillar array structure on the gate. The pH responses of the field effect device with nano-pillar structure were nonlinear. It seems that the plasma treatment of the Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> surface as well as a mixed composition of Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> and SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> may play an important role for the nonlinearity of the pH response. Oligonucleotide probes with fluorescent label were immobilized on the surface of the nano-pillar gate structure. The fluorescent intensity of the device with nano-pillar structure was stronger than that of the flat gate device. The increase of the fluorescent intensity for the nano-pillar device could be explained by the increase of the number of immobilized oligonucreotide probes because of the larger surface area. We can therefore expect highly sensitive detection of biomolecules with the nano-pillar gate field effect devices.