gebhart/patrepeval huggingface dataset:
Enfold (2014)

Dynamic voltage and frequency scaling (DVFS) has long been used as a technique to save power in a variety of computing domains but typically not in communications devices. A fundamental limit that prevents decreasing the clock frequency is the Nyquist(-Shannon) sampling theorem, which states that the sampling rate must be twice the signal bandwidth. Recently, researchers have leveraged compressive sensing to demonstrate the possibility of decoding a sparse signal below Nyquist rate. In this work, we dramatically extend the state of the art by showing how to decode non-sparse signals, in particular, OFDM systems at sub-Nyquist rates. We exploit the aliasing that results from under-sampling and observe that there exists well-defined structure in terms of how OFDM signals are "folded up" under aliasing. Based on our observations, we present Enfold, which allows existing WiFi chipsets to decode standards-compliant WiFi frames while operating at 50% and 25% of their rated clock rate. Our design is able to attain greater than 96% and 83% raw packet reception rates for moderate SNR while reducing the clock rate by 2x and 4x, respectively. Moreover, our approach can be easily applied to other communication systems based on OFDM modulation. When evaluated on popular smartphone app traces, Enfold reduces energy consumption by up to 34%.
The sounding of the charge at Balaclava (1928)

Journal Article The sounding of the charge at Balaclava Get access Frank Leslie Frank Leslie Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLV, Issue jul28, 28 July 1928, Pages 68–69, https://doi.org/10.1093/nq/CLV.jul28.68b Published: 28 July 1928
Erratum to: Replacement of Marine Fish Oil with <i>de novo</i> Omega‐3 Oils from Transgenic <i>Camelina sativa</i> in Feeds for Gilthead Sea Bream (<i>Sparus aurata</i> L.) (2017)

The article [Replacement of Marine Fish Oil with de novo Omega-3 Oils from Transgenic Camelina sativa in Feeds for Gilthead Sea Bream (Sparus aurata L.)], written by [Mónica B. Betancor, M. Sprague, D. Montero, S. Usher, O. Sayanova, P. J. Campbell, J. A. Napier, M. J. Caballero, M. Izquierdo, D. R. Tocher], was originally published electronically on the publisher's internet portal (currently SpringerLink) on [September 2, 2016] without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on April 7, 2017 to © The Author(s) [2017] and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Development of native, single crystal AlN substrates for device applications (2006)

Abstract Ultra‐low dislocation density aluminum nitride is a very promising substrate for many device structures based on the III–V nitride system. A better lattice and thermal expansion match than foreign substrates such as SiC or sapphire make AlN the substrate of choice for heteroepitaxial growth of AlGaN alloys, especially those with high aluminum concentration. In this paper, we show crystalline and chemical characterization of native aluminum nitride substrates, as well as characterization of AlGaN epilayers with 40 and 50% concentration of aluminum. The observation of atomic steps in atomic force microscope scans of the bare substrates and epilayers, as well as the narrow Full Width at Half Maximum (FWHM) measured on X‐ray diffraction, are an indication of both the good surface preparation of the substrates and quality of the epilayers. An estimation of defect density on epilayers grown by Migration Enhanced Metal Organic Chemical Vapour Deposition (MEMOCVD) resulted in mid 10 6 /cm 2 . (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hyper‐immunoglobulin M syndromes caused by intrinsic B‐lymphocyte defects (2005)

Hyper-immunoglobulin M (IgM) syndromes are primary immunodeficiencies characterized by normal or elevated serum IgM levels with the absence of other isotypes, pinpointing to a defect in the Ig class switch recombination (CSR). The delineation of hyper-IgM syndromes made it possible to better define the mechanisms underlying the two major events of antibody maturation in humans, CSR and introduction of somatic hypermutation (SHM) in the variable region of immunoglobulins. The description of the activation-induced cytidine deaminase (AID) deficiency, characterized by a defect in both CSR and SHM, demonstrated for the first time that this molecule acts as a master player in the antigen-induced Ig gene-modification events responsible for both CSR and SHM. However, deleterious mutations located in the C-terminus lead to a CSR defect without affecting SHM, providing evidence for a role of AID in CSR distinct from the cytidine deaminase activity, likely by binding to a specific CSR cofactor. Molecular causes of two other hyper-IgM conditions have not yet been defined. However, they may be caused by either a defect in AID targeting on S regions or a CSR-specific DNA-repair defect. The mechanism of action of AID remains somewhat debated, but the observation that uracil-DNA-glycosylase deficiency leads to a severe hyper-IgM syndrome strongly argues in favor of a DNA-editing activity of AID.
Monoclonal antibody therapy of murine lymphoma: enhanced efficacy by concurrent administration of interleukin 2 or lymphokine-activated killer cells. (1990)

Lymphokine-activated killer (LAK) cells have recently been shown to be very efficient effector cells for antibody-dependent cellular cytotoxicity. Thus, we explored, in a murine lymphoma model, administration of LAK-inducing doses of interleukin 2 (IL-2) or adoptive transfer of LAK cells as a means of enhancing therapy with tumor-specific monoclonal antibody (mAb). AKR/Cum (Thy-1.2+) hosts were inoculated on day 1 s.c. with the SL-2 thymoma of AKR/J origin (Thy-1.1+) and developed palpable tumor on day 4. Tumor-specific anti-Thy-1.1 IgG2a mAb, 1A14, was given on days 4 and 8 with 50,000 units/day IL-2 i.p. divided in two doses on days 4-12. Therapy with IL-2 or mAb alone had minimal activity, prolonging control median survival of 22 days to 25 and 29 days, respectively, whereas therapy with IL-2 plus mAb significantly prolonged median survival to 40 days. However, combined therapy did not result in cures and long term survival. The efficacy of combined therapy did not result from alterations in the biodistribution of mAb by concurrent IL-2 infusions, as determined by studies with radiolabeled mAb. The combined effect of in vitro generated LAK (10(8) cells) adoptively transferred i.v. with 1A14 on days 4 and 8 following SL-2 inoculation was also evaluated. This regimen had no detectable toxicity, and treatment of mice with LAK and mAb resulted in 60% long term survival compared with 17% or 0% for mice treated with mAb or LAK alone. Thus, the therapeutic effects of tumor-specific mAb was enhanced by in vivo administration of IL-2 or by adoptively transferred LAK, which may represent means to provide the host with increased antibody-dependent cellular cytotoxicity effector cells. Adoptively transferred LAK has the additional benefit of augmenting mAb therapy of tumor without the toxicity associated with the induction of such cells in vivo with high dose IL-2.
Abstract LB-373: Parp1 dependent regulation of chromatin remodeling by the ALC1 (Amplified in Liver Cancer) oncogene (2012)

Abstract The human ALC1 (Amplified in Liver Cancer 1) gene was originally identified as a gene present on a human chromosome 1q21 region amplified in a large fraction of hepatocellular carcinomas. Subsequent studies found that overexpression of the ALC1 protein was found to be oncogenic in human cells and mice, although the mechanism of action of ALC1 in oncogenesis is not known. The human ALC1 gene encodes a member of the SNF2 superfamily of ATPases. The ALC1 protein is unique among SNF2 family members because it includes a macrodomain that is capable of binding selectively to poly(ADP-ribose) (PAR). We and others have also previously demonstrated that ALC1 possesses DNA-dependent ATPase and ATP-dependent nucleosome remodeling activities that are strongly dependent on the presence of poly(ADP-ribose) polymerase PARP1 (or the closely related PARP2) and NAD+ within in vitro assays. Our preliminary investigation of the mechanism of PARP1- and NAD+-dependent activation of ALC1 DNA-dependent ATPase and nucleosome remodeling activities revealed (i) that both the ALC1 SNF2 ATPase domain and an intact macrodomain capable of binding PAR are essential for activation by PARP1 and NAD+, (ii) that activation of ALC1 in the presence of PARP1 and NAD+ results in increased affinity of ALC1 for DNA and nucleosomes, and (iii) that autoPARylated PARP1 is most likely the source of PAR required for activation of ALC1. These preliminary observations provided some insight into basic features of the function of the ALC1 protein, but they left unresolved major questions concerning the mechanism by which ALC1 is activated by PARP1 and NAD+ to remodel nucleosomes. In our recent studies, we extend our investigation of the mechanism by which ALC1 is “activated” to remodel nucleosomes by PARP1 and NAD+. Our findings argue that (i) ALC1 activation requires assembly of a stable ALC1.autoPARylated PARP1.nucleosome intermediate, (ii) that ALC1 regulates association of autoPARylated PARP1 with this intermediate, and (iii) stable binding of the ALC1 macrodomain to autoPARylated PARP1 is critical for ALC1 activation. Taken together, our findings are consistent with the model that a stable ALC1.autoPARylated PARP1 heterodimer is the active species in ALC1-dependent ATPase and nucleosome remodeling. These findings provide further important insight into the mechanism of action of this poorly understood oncogene. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-373. doi:1538-7445.AM2012-LB-373
Parameter estimation for the heat equation on perforated domains (2011)

Abstract In this effort we investigate the behavior of a model derived from homogenization theory as the model solution in parameter estimation procedures for simulated data for heat flow in a porous medium. We consider data simulated from a model on a perforated domain with isotropic flow and data simulated from a model on a homogeneous domain with anisotropic flow. We report on both ordinary and generalized least squares parameter estimation procedures.
Fanconi anemia manifesting as a squamous cell carcinoma of the hard palate: a case report (2006)

Fanconi anemia is a rare autosomal recessive disorder characterized by various congenital malformations, progressive bone marrow failure at a very young age and of solid tumors development. The authors present a rare case of a squamous cell carcinoma of the hard palate in a Fanconi Anaemia patient. The atypical clinical manifestation rendered the diagnosis more difficult. This case, for age of appearance, sex and localization, is unique in international literature. We recommend a quarterly follow up of the oral-rhino-pharynx complex in FA patients and to consider as carcinomas, all oral lesions that last more than two weeks.
Reactivity of nitric oxide with the [4Fe–4S] cluster of dihydroxyacid dehydratase from<i>Escherichia coli</i> (2008)

Although the NO (nitric oxide)-mediated modification of iron-sulfur proteins has been well-documented in bacteria and mammalian cells, specific reactivity of NO with iron-sulfur proteins still remains elusive. In the present study, we report the first kinetic characterization of the reaction between NO and iron-sulfur clusters in protein using the Escherichia coli IlvD (dihydroxyacid dehydratase) [4Fe-4S] cluster as an example. Combining a sensitive NO electrode with EPR (electron paramagnetic resonance) spectroscopy and an enzyme activity assay, we demonstrate that NO is rapidly consumed by the IlvD [4Fe-4S] cluster with the concomitant formation of the IlvD-bound DNIC (dinitrosyl-iron complex) and inactivation of the enzyme activity under anaerobic conditions. The rate constant for the initial reaction between NO and the IlvD [4Fe-4S] cluster is estimated to be (7.0+/-2.0)x10(6) M(-2) x s(-1) at 25 degrees C, which is approx. 2-3 times faster than that of the NO autoxidation by O2 in aqueous solution. Addition of GSH failed to prevent the NO-mediated modification of the IlvD [4Fe-4S] cluster regardless of the presence of O2 in the medium, further suggesting that NO is more reactive with the IlvD [4Fe-4S] cluster than with GSH or O2. Purified aconitase B [4Fe-4S] cluster from E. coli has an almost identical NO reactivity as the IlvD [4Fe-4S] cluster. However, the reaction between NO and the endonuclease III [4Fe-4S] cluster is relatively slow, apparently because the [4Fe-4S] cluster in endonuclease III is less accessible to solvent than those in IlvD and aconitase B. When E. coli cells containing recombinant IlvD, aconitase B or endonuclease III are exposed to NO using the Silastic tubing NO delivery system under aerobic and anaerobic conditions, the [4Fe-4S] clusters in IlvD and aconitase B, but not in endonuclease III, are efficiently modified forming the protein-bound DNICs, confirming that NO has a higher reactivity with the [4Fe-4S] clusters in IlvD and aconitase B than with O2 or GSH. The results suggest that the iron-sulfur clusters in proteins such as IlvD and aconitase B may constitute the primary targets of the NO cytotoxicity under both aerobic and anaerobic conditions.
Proposed Acoustic System for Ordnance Research Laboratory Water Tunnel (1949)

A description is given of the acoustic methods and equipment for detecting and locating sources of cavitation on underwater bodies and propellers (under test) in the high speed water tunnel now under construction at the Ordnance Research Laboratory at the Pennsylvania State College. Sound arising inside the tunnel will pass through an acoustically transparent window to an external tank in which is placed a small piezoelectric crystal hydrophone at the focus of an ellipsoidal reflector. The source of sound can thus be located because the hydrophone is most sensitive to sounds originating at the conjugate focus of the ellipsoid which is inside the tunnel. The reflector and hydrophone assembly has three degrees of freedom.
Highly anisotropic decay rates of single quantum dots in photonic crystal membranes (2010)

We have measured the variation of the spontaneous emission rate with polarization for self-assembled single quantum dots in two-dimensional photonic crystal membranes. We observe a maximum anisotropy factor of 6 between the decay rates of the two bright exciton states. This large anisotropy is attributed to the substantially different projected local density of optical states for differently oriented dipoles in the photonic crystal.
Coordination isomers of biological iron transport compounds. IV. Geometrical isomers of chromic desferriferrioxamine B (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoordination isomers of biological iron transport compounds. IV. Geometrical isomers of chromic desferriferrioxamine BJohn Leong and Kenneth N. RaymondCite this: J. Am. Chem. Soc. 1975, 97, 2, 293–296Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/ja00835a011https://doi.org/10.1021/ja00835a011research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Feasibility of damage detection of Tsing Ma Bridge using vibration measurements (2000)

In this paper, we study the feasibility of vibration-based damage identification methods for the instrumented Tsing Ma Suspension Bridge with a main span of 1377 m. Emphasis is placed on how to deal with the noise-corrupted/uncertain measurement data and how to use the series data from the on- line monitoring system for damage detection. Numerical simulation studies of using the noisy series measurement modal data for damage occurrence detection with the auto-associative neural network and for damage localization with the probabilistic neural network are presented. Five neural network based novelty detectors using only natural frequencies of the intact and damaged structure are first developed for the detection of damage occurrence in the Tsing Ma Bridge. The noisy/uncertain measurement data are produced by polluting the analytical natural frequencies with random noise. Numerical simulations of a series of damage scenarios show that when the maximum frequency change caused by damage exceeds a certain threshold, the occurrence of damage can be unambiguously flagged with the novelty detectors. A probabilistic neural network using noisy modal data (natural frequencies and incomplete modal vectors) is then constructed for the localization of damage occurring at the Tsing Ma Bridge deck. The main-span deck is divided into 16 segments and the damage in each segment is defined as a pattern class. The analytical modal data for each pattern class are artificially corrupted with random noise and then used as training samples to establish a three-layer probabilistic neural network for damage localization. A preliminary investigation shows that the damage to deck members can be localized only when the level of the corrupted noise is low.
at two sites in recombinant human Ë 1 -adrenoceptors and interaction with Ë -blockers (2004)

To verify the hypothesis that the non-conven- tional partial agonist (-)-CGP12177 binds at two β1-adreno- ceptor sites, human β1-adrenoceptors, expressed in CHO cells, were labelled with (-)-( 3 H)-CGP12177. We compared the binding affinity and antagonist potency of 12 clinically used β-blockers against the cyclic AMP-enhancing effects of (-)-isoprenaline and (-)-CGP12177.(-)-( 3 H)-CGP12177 bound to a high affinity site (H; KH=0.47 nM) and low affinity site (L); KL=235 nM). (-)-( 3 H)-CGP12177 disso- ciated from the β1-adrenoceptors with a fast component (koff=0.45 min -1 ), consistent with the L-site, and a slow component (koff=0.017-0.033 min -1 ), consistent with the H-site. (-)-Isoprenaline and (-)-CGP12177 caused 96-fold and 12-fold maximal increases in cyclic AMP levels with -logEC50M of 8.2 and 7.6. (-)-CGP12177 antagonised the effects of (-)-isoprenaline with a pKB of 9.9. The β-block- ers antagonised the effects of (-)-isoprenaline more than the effects of (-)-CGP12177 with potency ratios: (-)-atenolol 1,000, (±)-metropolol 676, (-)-pindolol 631, (-)-timolol 589, (±)-carvedilol 204, (±)-oxprenolol 138, (±)-sotalol 132, (-)-propranolol 120, (±)-bisoprolol 95, (±)-alprenolol 81, (±)-nadolol 68 and (-)-bupranolol 56. In intact cells the binding constants of β-blockers, estimated from competi- tion with 3-5 nM (-)-( 3 H)-CGP12177 (binding to the H-site), correlated with the corresponding affinities esti- mated from antagonism of the (-)-isoprenaline effects. We conclude that (-)-( 3 H)-CGP12177 binds at two sites in the recombinant β1-adrenoceptor. (-)-CGP12177 is an antagonist of catecholamine effects through the H-site and a non-conventional partial agonist through the L-site. β-blockers are more potent antagonists through the H-site than the L-site.
[Therapeutic efficacies of neticonazole (SS717) cream and solution in experimental cutaneous Candida albicans infection of guinea pigs]. (1993)

The therapeutic efficacies of 1% neticonazole (SS717) cream and solution on experimental cutaneous Candida albicans infection produced in prednisolone-treated guinea pigs were compared with those of 1% bifonazole (BFZ). Active preparations or blank vehicles were applied once daily for 3 consecutive days starting 5 days postinfection. Therapeutic effects were assessed on the basis of viable counts recovered from the infected loci 9 days postinfection. In animals treated with SS 717 or BFZ cream, a significant mycological improvement was observed when compared to untreated controls. A significant therapeutic efficacy of a SS717 cream compared to cream vehicle was also noted, while there was no significant difference in the recovery of Candida between the untreated control group and the cream vehicle-treated groups. The mycological result of the SS717 solution treated group was significantly superior to those of the untreated control group, the solution vehicle-treated group and the BFZ solution-treated group. The treatment with a solution vehicle or a BFZ solution appeared to lower, though not to a significant level, viable counts at the infected loci. These results led us to the conclusion that both SS717 cream and solution preparations exhibited significantly superior activity to that of BFZ in experimental cutaneous candidasis of guinea pigs.
Cellular plasma membrane domains (1995)

The plasma membranes of migrating cells differentiate into at least three distinct domains as defined by the laser tweezers and the motile behaviour of particles bound to specific membrane glycoproteins. These domains are important for steps in the cell migration process. First, there is a domain at the leading edge of the lamellipodium where preferential attachment of cross-linked glycoproteins to the cytoskeleton occurs. The second domain at the rear of the cell is differentiated for releasing from substrata and shows decreased support of the membrane by the cytoskeleton. The third domain is the highly curved region(s) of the plasma membrane wherein certain membrane glycoproteins concentrate and is a site for controlling extension and attachment. Using single particle tracking and video analysis we find that the quantitative differences between plasma membrane domains are in the 4-20-fold range at any given time. These values are consistent with the rapid fluctuations seen in cell migration rates and directions. Over a longer time-scale, cells can possibly integrate these selective advantages to give a much higher overall fidelity for cell chemotaxis and neuronal path finding.
Beiträge zur Keramik hochfeuerfester Stoffe. VI. Das System ZrO<sub>2</sub>MgO (1933)

Abstract Auf Grund röntgenographischer und chemisch‐analytischer Untersuchungen gesinterter und geschmolzener Proben wechselnder Zusammensetzung im System ZrO 2 MgO und unter Zuhilfenahme eines Schmelzdiagramms wird das Zustandsdiagramm des System ZrO 2 MgO (vgl. Fig. 5) aufgestellt.