gebhart/patrepeval huggingface dataset:
Mapping of Copper/Hydrogen Peroxide-induced DNA Damage at Nucleotide Resolution in Human Genomic DNA by Ligation-mediated Polymerase Chain Reaction (1995)

The ligation-mediated polymerase chain reaction was used to map the frequency of reactive oxygen species-induced DNA damage at nucleotide resolution in genomic DNA purified from cultured human male fibroblasts. Damaged pyrimidine and purine bases were recognized and cleaved by the Nth and Fpg proteins from Escherichia coli, respectively. Strand breaks and modified bases were induced in vitro by copper ion-mediated reduction of hydrogen peroxide in the presence of ascorbate; reactant concentrations were adjusted to induce lesions at a frequency of 1 per 2-3 kilobases in purified genomic DNA. Glyoxal gel analysis demonstrated that the ratio of induced strand breaks to induced base damage was 0.8/2.7 in DNA dialyzed extensively to remove adventitious transition metal ions. Ligation-mediated polymerase chain reaction analysis of the damage frequency in the promoter region of the transcriptionally active phosphoglycerate kinase (PGK 1) gene revealed that (Cu(II)/ascorbate/H2O2 caused DNA base damage by a sequence-dependent mechanism, with the 5' bases of d(pGn) and d(pCn) being damage hot spots, as were the most internal guanines of d(pGGGCCC) and d(pCCCGGG). Since base damage occurs after formation of a DNA-Cu(I)-H2O2 complex, these data suggest that the local DNA sequence affects formation of DNA-Cu(I)-H2O2 complexes and/or the efficiency of base oxidation during resolution of this complex.
High-affinity Nod factor binding site from <em>Phaseolus vulgaris</em> cell suspension cultures (2002)

0894-0282 Journal Article
When a minor head injury results in enduring symptoms: a prospective investigation of risk factors for postconcussional syndrome after mild traumatic brain injury (2011)

The study provides good support for the proposed cognitive behavioural model. Patients' perceptions of their head injury and their behavioural responses play important roles in the development of PCS, indicating that cognitive and behavioural factors may be potential targets for early preventive interventions.
Hall coefficient and oxygen stoichiometry in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi mathvariant="normal">Y</mml:mi><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ba</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mo>−</mml:mo><mml:mi>δ</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>ceramics at elevated temperatures (1988)

The Hall coefficient and resistivity of polycrystalline ceramic samples of $\mathrm{Y}{\mathrm{Ba}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}\ensuremath{\delta}}$ were measured at elevated temperatures and at various ambient ${\mathrm{O}}_{2}$ partial pressures and correlated with separate thermogravimetric measurements of $\ensuremath{\delta}$. In the region where the oxygen stoichiometry reaches equilibrium with the external ${\mathrm{O}}_{2}$, it is shown by isothermal plots that the Hall number density decays exponentially with increasing $\ensuremath{\delta}$ and the effective Hall mobility is weakly dependent on $\ensuremath{\delta}$. Although transport coefficients are temperature dependent, this result lends support to the picture that oxygen doping in the cuprate acts mainly to modulate the density of hole carriers.
Roentgenographically Occult Bronchogenic Adenocarcinoma Detected by Sputum Cytology for Mass Screening (1999)

Mass screening program for early detection of lung cancer has been conducted in Miyagi Prefecture, Japan, and over 180,000 heavy smokers have been screened. We report a very rare case with bronchogenic adenocarcinoma detected by sputum cytology without abnormal findings on chest radiograph or computed tomography (CT). A 75-year-old man was suspected of having adenocarcinoma of the lung by sputum cytology for mass screening. Chest radiograph and CT did not show any abnormal findings. Bronchoscopic findings showed that there was no polypoidal lesion in the bronchi, but a lesion with redness and thickening of the bronchial surface stretched from the left main bronchus to subsegmental bronchi of B6, B8, and B10 of the left lower lobe. Brushing cytology and transbronchial biopsy confirmed that the lesion was a bronchogenic adenocarcinoma, and left pneumonectomy was performed. Histologic examination with serial block sectioning showed that the tumor was a poorly differentiated tubular adenocarcinoma and its invasion was confined within the bronchial wall.
Mode of action of a bactericidal protein induced in the haemolymph of <i>Sarcophaga peregrina</i> (flesh-fly) larvae (1984)

The mode of action of a bactericidal protein (sarcotoxin I) purified from the haemolymph of Sarcophaga peregrina (flesh-fly) larvae was studied, focusing attention on its effect on the function of the membrane of Escherichia coli. Sarcotoxin I almost completely blocked the uptakes of tetraphenylphosphonium ion and proline, which are known to be driven by a membrane potential, indicating that this protein disrupts the membrane potential of bacteria.
Postocclusive reactive hyperemia estimating peripheral vascular resistance: a noninvasive method to predict outcome of infrainguinal vascular reconstructions? (1996)

Several parameters during reactive hyperemia show weak correlation to intraoperatively measured peripheral resistance, but none was able to accurately predict graft failure. Further studies are needed to evaluate its capability for patient selection.
Metal‐Catalyzed Oxidation and Epoxidation of α‐Hydroxy Vinyl and Dienyl Sulfoxides. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The effects of dasatinib on IgE receptor–dependent activation and histamine release in human basophils (2008)

Dasatinib is a multitargeted drug that blocks several tyrosine kinases. Apart from its well-known antileukemic activity, the drug has attracted attention because of potential immunosuppressive and anti-inflammatory effects. We report that dasatinib at 1 microM completely blocks anti-IgE-induced histamine release in blood basophils in healthy donors, and allergen-induced release of histamine in sensitized individuals. In addition, dasatinib inhibited FcepsilonRI-mediated release of IL-4 and IgE-mediated up-regulation of CD13, CD63, CD164, and CD203c in basophils. The effects of dasatinib were dose-dependent (IC(50): 50-500 nM) and specific for FcepsilonRI activation in that the drug failed to inhibit C5a-induced or Ca-ionophore-induced histamine release. Interestingly, at lower concentrations, dasatinib even promoted FcepsilonRI-dependent histamine release in basophils in allergic subjects. In consecutive studies, dasatinib was found to interact with and block several FcepsilonRI downstream targets in basophils, including Btk. Correspondingly, FcepsilonRI-mediated histamine secretion in basophils was markedly reduced in Btk knockout mice and in a patient with Btk deficiency. However, the remaining "low-level" mediator secretion in Btk-deficient cells was fully blocked down again by 1 muM dasatinib. Together, these data suggest that dasatinib inhibits FcepsilonRI-mediated activation of basophils through multiple signaling molecules including Btk. Dasatinib may be an interesting agent for immunologic disorders involving Btk-dependent responses or/and FcepsilonRI activation of basophils.
ChemInform Abstract: High‐Salt and Low‐Salt Models for Kinked Adducts of cis‐Diamminedichloroplatinum(II) with Oligonucleotide Duplexes. (1986)

Abstract Using the Computer graphics system FRODO PS‐300 and AMBER refinements the structural parameters for two model structures of cis‐[Pt(NH3)2] adducts of [d(TCTCGGTCTC)‐d(GAGACCGAGA)‐ N7(5),N7(6)] are determined.
A 3D field scale streamline simulator with gravity and changing well conditions (1996)

We present a new 3D streamline technique that represents a major advance in the application of streamlines to model field scale flow. Our method involves mapping numerical solutions along streamlines rather than the traditional practice of mapping analytical solutions. The new method accounts for gravity effects in first-contact miscible displacements and changing well conditions that would result from infill drilling or well conversions. Our new method still retains accuracy and orders of magnitude speedup factors over conventional finite difference methods. We trace streamlines from injectors to producers in a 3D permeability field, whose paths are dictated by the heterogeneity and the well conditions. The new approach centers on mapping the existing distribution of state variables from the underlying Cartesian grid onto the streamlines, moving the variables forward in time and space along the streamlines using a 1D numerical solver, and then mapping the solution back onto the underlying grid. In this manner, the fluid is moved along a natural streamline grid that is decoupled from the underlying grid on which the pressure field is solved. The advantages of this decoupling include minimal grid orientation effects, reduced numerical diffusion, and removal of the global grid CFL stability criterion. The streamline methodmore » exhibits large speedup factors over conventional schemes because both fewer convection steps and pressure solves are required. We present results of the new streamline method applied to 2D and 3D multi-well displacements. Where possible, comparisons with conventional methods indicate that the streamline model is more accurate and up to 600 times faster. We also present results of a field scale, million-gridblock 36-well water-flood that includes a pattern modification plan to improve oil recovery. In comparison, the upscaled conventional finite difference results over predicted incremental oil recovery due to infill drilling.« less
Adaptive optics projects at ESO (2003)

Over the past two years ESO has reinforced its efforts in the field of Adaptive Optics. The AO team has currently the challenging objectives to provide 8 Adaptive Optics systems for the VLT in the coming years and has now a world-leading role in that field. This paper will review all AO projects and plans. We will present an overview of the Nasmyth Adaptive Optics System (NAOS) with its infrared imager CONICA installed successfully at the VLT last year. Sodium Laser Guide Star plans will be introduced. The status of the 4 curvature AO systems (MACAO) developed for the VLT interferometer will be discussed. The status of the SINFONI AO module developed to feed the infrared integral field spectrograph (SPIFFI) will be presented. A short description of the Multi-conjugate Adaptive optics Demonstrator MAD and its instrumentation will be introduced. Finally, we will present the plans for the VLT second-generation AO systems and the researches performed in the frame of OWL.
Topics in FMCW radar disturbance suppression (1997)

The paper discusses the disturbance situation of an FMCW radar, particularly that of a car cruise control sensor (car radar) in dense traffic. Simple time- and frequency-sharing arguments do not evaluate the disturbance situation correctly; there are in general more disturbances than these methods indicate. However, a suitable disturbance suppression policy will make the FMCW radar quite interference-resistant. In particular, well-known methods from digital signal processing can be used for suppressing both short (pulse-like) and longer (chirp-like) disturbances. Several methods are illustrated (non-mathematically), using entire road scenarios of real or simulated data.
New Methods for the Formation of Methyl Bearing Stereogenic Centers via Methylketene Dimerization and Free Radical Additions to Allyl Bromides (2002)

Two organic synthetic methods for the generation of methyl bearing chiral centers have been developed using: 1) dimerization of methylketene and 2) a free radical-based addition/elimination reaction involving allyl bromides. The first method, the asymmetric dimerization of methyl ketene, followed by an asymmetric aldol reaction and the appropriate functional group manipulations enabled us to construct the (2S, 4S, 6S) trimethylnonyl subunit found in the siphonariene class of natural products. The latter method explored the stereoselective potential of a free radical-based condensation reaction by examining compounds which are known to be able to support chiral auxiliaries and chiral Lewis acids. Additionally, substituent effect on the rates of this reaction were examined closely and found to be comparable to similar, previously examined systems. The synthetic utility, magnitude and scope of this reaction are discussed.
ChemInform Abstract: Synthesis of Substituted Benzimidazoles via Tosylation of N‐Aryl Amidoxime. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reduction of Pupil Size and Halos With Minus Lenses After Laser in situ Keratomileusis (2004)

Pupil diameters and halos decreased with a -1.00-D overcorrection in patients following LASIK. Patients with pupil-dependent night halos after LASIK may benefit from mildly over-minused lenses.
Activity of the nicotinamide mononucleotide transport system is regulated in Salmonella typhimurium (1991)

Transport of nicotinamide mononucleotide (NMN) requires two functions, NadI(T) and PnuC. The PnuC protein is membrane associated, as judged by isolation of active TnphoA gene fusions and demonstration that the fusion protein is membrane associated. The PnuC function appears to be the major component of the transport system, since mutant alleles of the pnuC gene permit NMN transport in the absence of NadI(T) function. We present evidence that the activity of the NMN transport system varies in response to internal pyridine levels (presumably NAD). This control mechanism requires NadI(T) function, which is provided by a bifunctional protein encoded by the nadI gene (called nadR by Foster and co-workers [J. W. Foster, Y. K. Park, T. Fenger, and M. P. Spector, J. Bacteriol. 172:4187-4196]). The nadI protein regulates transcription of the nadA and nadB biosynthetic genes and modulates activity of the NMN permease; both regulatory activities respond to the internal pyridine nucleotide level.
Fecal Carriage of Carbapenemase-Producing Enterobacteriaceae: a Hidden Reservoir in Hospitalized and Nonhospitalized Patients (2012)

Fecal carriage of carbapenemase-producing Enterobacteriaceae (CPE) has not been extensively investigated, except in the cases of selected patients at risk, mostly during outbreaks. A total of 1,100 fecal samples randomly collected in our institution in two different periods in 2006 (n = 600) and 2009-2010 (n = 500) from hospitalized (26.8%) and nonhospitalized (73.2%) patients were screened for CPE. The first period coincided with an outbreak of VIM-1-producing Enterobacteriaceae, and the second one coincided with the emergence of KPC enzymes in our hospital. Diluted samples in saline were cultured in Luria-Bertani broth with 1 μg/ml imipenem and subcultured in MacConkey agar plates with 4 μg/ml ceftazidime. Growing colonies were screened for CPE (modified Hodge test and EDTA and boronic acid synergy tests). Carbapenemase genes, plasmids in which they are located, and clonal relatedness were determined. Individuals who exhibited fecal carriage of CPE (11/1,043, 1.1%; 95% confidence interval [CI], 0.53 to 1.88) included 8 hospitalized (carriage rate, 2.9%; 95% CI, 1.24 to 5.55) and 3 nonhospitalized patients (carriage rate, 0.4%; 95% CI, 0.08 to 1.14), the latter being identified in 2009. Eighty-two percent of colonized patients were not infected with CPE. Isolates harboring bla(VIM-1) with or without bla(SHV-12) were identified as Klebsiella pneumoniae (n = 8; ST39, ST688, ST253, and ST163), Enterobacter cloacae (n = 3; two pulsed-field gel electrophoresis [PFGE] types), Escherichia coli (n = 2; ST155 and ST2441), and Citrobacter freundii (n = 1). Some of these lineages had previously been detected in our institution. The bla(VIM-1) gene was a member of the class 1 integrons In110 (bla(VIM-1)-aacA4-aadA1) and In113 (bla(VIM-1)-aacA4-dhfrII) located on plasmids IncN (n = 11; 30 to 50 kb) and IncHI2 (n = 3; 300 kb), respectively. Dissemination of bla(VIM-1) class-1 integrons within highly transferable plasmids in a polyclonal population has potentially contributed to the maintenance and spread of CPE.
Concurrent monitoring environment for obtaining IPFIX flow and signature based IDS alert data (2012)

The aim of this paper is to introduce and untangle the operating model of a network monitoring environment that handles flow and signature based techniques side by side on a large-scale campus network. This paper introduces one approach for solving the problematic creation of standard-based flow information and signature alarms in tandem from large-scale network traffic. The operating model takes into account cost efficiency, trustworthy and privacy protection. Due to the Privacy Protection Act and local laws, data analysis is made after traffic anonymization.
Footwear effects on lower extremity coordination (2015)

During both walking and running, barefoot gait is associated with a reduced stride length and higher cadence. Similarly, significant differences in joint kinematics have been reported during barefo...
Abstract P30. Ultrasonic Mapping of the Abdominal Wall using ARFI-SWV: A Prospective Trial to Determine the Physiologic Basis for Reconstruction (2017)

Purpose: Current indices of risk evaluation for abdominal wall reconstruction focus on thickness and fat measurements, but do not address abdominal wall elasticity and texture assessment. Acoustic-Radiation-Forced-Impulse-Shear-Wave-Velocity (ARFI-SWV) is a novel technology to assess skeletal muscle tissue characteristics. This technique has not assessed the abdominal wall physiology for reconstructive patients on a plastic surgery service. Methods: Texture analysis and ARFI-SWV of the internal and external oblique (IO and EO) were performed on 36 subjects. Ten subjects qualified as high-physical activity according to IPAQ guidelines, sixteen were awaiting abdominal wall reconstruction, and ten were age and BMI matched to the operative candidates. Results: When comparing the active vs. pre-operative patient’s abdominal wall constructs, significant differences were shown in pre-hepatic fat thickness (p=0.037), pre-peritoneal fat thickness (p=0.005), IO thickness (p=0.001), subcutaneous fat thickness (p=0.003), and SWV in IO (p=0.023) and EO (p=0.013). The matched patients showed significant differences to the pre-operative grouping in pre-peritoneal fat thickness (p=0.022) and IO thickness (p=0.03). Finally the active and matched group differed in EO thickness (p=0.005). Mean brightness EO and IO ratio of hernia patients (EO 2.29; IO 1.59) was greater than matched controls (EO 2.05; IO 1.3) as well as the active controls (EO 1.2; IO 0.82). Conclusion: ARFI-SWV is an excellent technique to measure stiffness of the abdominal wall musculature, providing consistent results. Textural analysis has potential to predict abdominal wall weakness. The physiologic basis of the abdominal wall in reconstruction patients differs from healthy counterparts, contributing to eventual failure and need for repair.
Evaluation of heat-treating heartworm-positive canine serum samples during treatment with Advantage Multi® for Dogs and doxycycline (2018)

The DiroCHEK accurately diagnosed all dogs with live adults recovered at necropsy as heartworm antigen positive and all those dogs with no live adults recovered at necropsy as heartworm antigen negative without the use of heat-treatment for samples taken on the day of necropsy. Therefore, these results indicate that the use of heat-treating serum samples did not provide data of any additional value in the diagnosis of heartworm-positive dogs receiving treatment in this study. Additionally, these results may indicate that the conversion of serum samples from negative to positive for the presence of heartworm antigen with heat-treatment may not always accurately diagnose live adult heartworm infections since no adult heartworms were recovered at necropsy for those dogs in which a conversion event occurred. These conversion events may be detecting residual antigen leftover after all adult worms have died or may even be detecting off- target antigens, which have been denatured during heat-treatment. While a necropsy was not performed at the time of the conversion events, no live adult worms were recovered from any of the dogs in which a conversion event occurred earlier in treatment.
Mechanisms for the Maintenance of Ventricular Fibrillation: The Nonuniform Dispersion of Refractoriness, Restitution Properties, or Anatomic Heterogeneities? (2005)

Neither the dispersion of refractoriness nor action potential duration restitution determined during rapid pacing by itself is the major determinant of the location of conduction block during early VF in normal pigs. It may be that these factors interact synergistically with each other as well as with other factors, including anatomic heterogeneities such as those caused by blood vessels, which may be particularly important for the formation of conduction block and maintenance of VF.
An automatic X-ray isodose plotter (1963)

When a tank of water, which is usually used to simulate human tissue, is exposed to a broad beam of X-rays the dose distribution in the water, in any plane, can be described by a family of isodose curves. The device described in this article draws such curves by recording the path of a small ionization chamber, which automatically follows preselected isodose lines, in the water. The design factors which determine the accuracy of the results are discussed.
Modification of Sensing Properties of Thin Polymer Films by VUV Irradiation (2007)

The use of patternable polymeric films and their subsequent VUV irradiation treatment to engineer individual sensitivities in chemical sensor arrays is proposed. The structural changes of irradiated areas involve scission of polymeric chains, cross-linking and formation of new bonds. In addition, 157 nm induces surface and volume morphological changes in the micro/nano domain with different shapes, depending on the irradiation conditions. The effect of VUV irradiation on the swelling properties of polymethylmethacrylate (PMMA) thin films in certain analytes is studied using white light reflectance spectroscopy. The relative expansion of the PMMA film was clearly found to depend on the irradiation conditions.
Effects of skin cleaning modes on the condition of collagen and elastin after laser resurfacing (2000)

It is suggested that the abrasive action caused by the gauze adds to the existing stimulative inflammatory reaction following CO2 laser resurfacing, which augments the collagen and fibre compaction response in the tissue. Comparatively aggressive cleaning with damp gauze may therefore be preferable to other methods when performing laser resurfacing.