gebhart/patrepeval huggingface dataset:
Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells <i>in vitro</i> (1992)

Endothelioma cells expressing the polyoma virus middle T oncogene induced hemangiomas in mice by the recruitment of nonproliferating endothelial cells from host blood vessels (Williams et al. 1989). I now report that SPARC, a Ca 2+ -binding glycoprotein that perturbs cell–matrix interactions and inhibits the endothelial cell cycle, is produced by endothelioma cells and is in part responsible for the alterations in the morphology and growth that occur when nontransformed bovine aortic endothelial cells are cocultured with endothelioma cells. Normal endothelial cells cocultured with two different middle T-positive endothelial cell lines, termed End cells, exhibited changes in shape that were accompanied by the formation of cell clusters. Media conditioned by End cells repressed proliferation of normal endothelial cells, but enhanced that of an established line of murine capillary endothelium. Radiolabeling studies revealed no apparent differences in the profile of proteins secreted by aortic or capillary cells cultured in End cell conditioned media. Characterization of proteins produced by End cells led to the identification of type IV collagen, laminin, entactin, and SPARC as major secreted products. Although SPARC did not affect the morphology of End or capillary cells, it was associated with overt changes in the shape of aortic endothelial cells. Moreover, SPARC and a synthetic peptide from SPARC domain II inhibited the incorporation of [ 3 H]thymidine by aortic cells, but had minimal to no effect on the capillary endothelial cell line. The inhibition of growth exhibited by aortic endothelial cells cultured in End cell conditioned media could be partially reversed by antibodies specific for SPARC and SPARC peptides. These studies indicate a potential role for SPARC in the generation of hemangiomas by End cells in vivo, a process that requires normal (host) endothelial cells to disengage from the extracellular matrix, withdraw from the cell cycle, migrate, and reassociate into the disorganized cellular networks that comprise cavernous and capillary hemangiomas.Key words: endothelial cells, hemangioma, cell proliferation, SPARC.
A Preliminary Research of 52 Chemotherapy Patients with Central Vein Catheter(CVC) Infection (2000)

对需要化疗的肿瘤病人,行中心静脉导管(CVC)置管并经此反复给药,是一种减轻病人痛苦、方便治疗的常用诊疗技术,但CVC感染往往伴有菌血症,时常因病情严重而治疗困难.52例CVC置管化疗引起实际感染率为14.6%,其原因:一是抗肿瘤药杀伤白细胞,使机体的免疫功能下降;二是置管时间较长,创口处理不当,细菌经导管漫延扩散而致菌血症;其三是晚期肿瘤病人长期卧床抗感染能力下降.因此,对CVC感染除针对性使用大剂量抗生素外,加强护理也是降低感染率的重要措施之一.护理内容包括:(1)在化疗期间密切监测病人白细胞的变化,对白细胞显著下降者应使用升白细胞的药物;(2)定期消毒处理创口周围皮肤和外露导管,更换覆盖无菌敷料,一般隔日1次,天气炎热,每日1次;(3)每日进行病室紫外线照射和空气消毒;(4)协助病人多下床运动,以增强机体抗感染能力.
Non-Coding RNAs: The “Dark Matter” of Cardiovascular Pathophysiology (2013)

Large-scale analyses of mammalian transcriptomes have identified a significant number of different RNA molecules that are not translated into protein. In fact, the use of new sequencing technologies has identified that most of the genome is transcribed, producing a heterogeneous population of RNAs which do not encode for proteins (ncRNAs). Emerging data suggest that these transcripts influence the development of cardiovascular disease. The best characterized non-coding RNA family is represented by short highly conserved RNA molecules, termed microRNAs (miRNAs), which mediate a process of mRNA silencing through transcript degradation or translational repression. These microRNAs (miRNAs) are expressed in cardiovascular tissues and play key roles in many cardiovascular pathologies, such as coronary artery disease (CAD) and heart failure (HF). Potential links between other ncRNAs, like long non-coding RNA, and cardiovascular disease are intriguing but the functions of these transcripts are largely unknown. Thus, the functional characterization of ncRNAs is essential to improve the overall understanding of cellular processes involved in cardiovascular diseases in order to define new therapeutic strategies. This review outlines the current knowledge of the different ncRNA classes and summarizes their role in cardiovascular development and disease.
Distributed Estimation in a Power Constrained Sensor Network (2006)

This paper derives the optimum non-uniform quantization scheme for a distributed estimation problem based on noisy observations in a wireless sensor network. The optimal quantization scheme minimizes the mean squared estimation error subjected simultaneously to both a total system power as well as individual node power constraints. According to the derived optimal scheme, sensors with poor signal-to-noise ratios (SNR) refrain from transmitting their observations. The rest of the sensors transmit their quantized observations. The number of quantized bits depends on the SNR and the maximum power constraint at each node. The numerical results show that compared to a uniform power allocation scheme, the proposed scheme achieves significantly smaller Mean Squared Error (MSE) for the same average power consumption.
Influence of pH on Dendrimer-Protected Nanoparticles (2002)

Highly stable, isolated, and monodisperse Ag nanoparticles, protected by poly(amidoamine) (PAMAM) dendrimers, were prepared via direct chemical reduction. UV−visible absorption, dynamic light scattering, and transmission electron microscopy have been used to study the structure and behavior of the nanocomposites as a function of pH. The data show that pH is a critical determinant of aggregation in PAMAM dendrimers, and that dendrimer aggregation, in turn, strongly influences nanoparticle stability against flocculation. The results allow for a complete understanding of previously reported difficulties in preparing Ag nanoparticles by this method.
Computation of Pressure Fields for a Hybrid Particle-Mesh Method (2014)

A hybrid particle-mesh method based on the vorticity-velocity formulation for solving the incompressible Navier-Stokes equations is a combination of the Vortex-In-Cell(VIC) method for convection and the penalization method for diffusion. The key feature of the numerical methods is to determine velocity and vorticity fields around a solid body on a temporary grid, and then the time evolution of the flow is computed by tracing the convection of each vortex element using the Lagrangian approach. Assuming that the vorticity and velocity fields are to be computed in time domain analysis, pressure fields are estimated through a complete set of solutions at present time step. It is possible to obtain vorticity and velocity fields prior to any pressure calculation since the pressure term is eliminated in the vorticity-velocity formulation. Therefore, pressure field is explicitly treated by solving a suitable Poisson equation. In this paper, we propose a simple way to numerically implement the vorticity-velocity-pressure formulation including a penalty term. For validation of the proposed numerical scheme, we illustrate the early development of viscous flows around an impulsive started circular cylinder for Reynolds number of 9500.
Improving CPU and GPU Performance through Sample-Based Dynamic LLC Bypassing (2018)

The current trend toward integrated central processing units (CPUs) and graphics processing units (GPUs) on the same chip presents new challenges for the efficient and fair sharing of resources. Unlike traditional multicores, CPU and GPU cores in the integrated architecture can generate diverse cache traffics and exhibit quite different temporal or spatial data localities. The shared last-level cache (LLC) between the two can result in a large amount of interference between CPU and GPU LLC accesses, thus impacting the performance of both the CPUs and GPUs. Cache bypassing is a promising method to improve LLC performance and to alleviate resource contention between CPUs and GPUs. However, inefficient cache bypassing may lead to significant Network on Chip (NoC) traffic congestion and subsequent performance degradation, particularly for a CPU on a heterogeneous CPU-GPU system with an on-chip ring network. To manage the LLC more efficiently, we propose a sample-based dynamic cache bypassing method for shared LLC in heterogeneous CPU-GPU multicore systems. This method samples the LLC miss rates and NoC traffics for both the CPU and GPU at run-time and uses a statistical bypassing decision-making model to intelligently decide whether to bypass or not. Our experiments show that bypassing CPU can be more useful than bypassing GPU for integrated CPU-GPU architecture with ring-based NoC topology. Our results indicate that bypassing both CPU and GPU can improve CPU performance by 34.30% and GPU performance by 3.20%, while bypassing CPU alone enhances CPU performance by 38.09% and GPU performance by 1.11%, and bypassing GPU alone increases CPU performance by 4.12% and GPU performance by 2.60%, on average.
Energy balance in the newborn baby: use of a manikin to estimate radiant and convective heat loss (1982)

Convective and radiant heat loss from a baby in an incubator were studied using a heated manikin. The mean radiant temperature of surrounding surfaces other than those vertically below the manikin was measured. The coefficients Af and hr were calculated as though this was the mean radiant temperature of the whole environment. The fraction (Af) of the body surface area which exchanged radiant energy with the surroundings increased from 0.48 for a foetal posture to 0.76 for a spreadeagle posture due to a decrease in radiant exchange between opposing body surfaces. The corresponding increase in the coefficient for heat exchange by radiation (hr) was from 3.1 to 4.9 Wm-2 K-1. The coefficient for convection (hc) increased from 4.0 to 5.4 WM-2 K-1 due to a decrease in effective body diameter as the limbs moved away from the trunk. These changes in Af, hr and hc show that posture is important in regulating heat loss from a baby. As the radiant temperature of the incubator canopy was between 2 and 4K below incubator air temperature, a baby loses more heat by radiation than by convection.
Sources of Error in Spectrophotometric Measurement of Aspartate Aminotransferase and Alanine Aminotransferase Activities in Serum (1974)

Abstract We examined the measurement of serum aspartate and alanine aminotransferase activities with a short-interval enzyme-activity analyzer. Double-beam spectrophotometry was used to elucidate the source of errors in such measurements. For both enzymes the principal error sources are: (a) the presence of endogenous substrate for lactate dehydrogenase, and (b) reaction of 2-oxoglutarate with serum glutamate dehydrogenase and ammonium ions added to the reaction mixture in admixture with the secondary enzymes of the coupled reactions. In the case of serum aspartate aminotransferase, a less important source of error is the reaction of serum alanine aminotransferase with endogenous substrate. Use of 2-oxoglutarate as a reaction initiator in conventional methods causes errors. Suitable blank reagent mixtures are described that permit accurate, rapid measurement of these activities by double-beam spectrophotometry in a short-interval enzyme-activity analyzer.
Using multimedia to emphasize the development of professional abilities (1995)

This paper presents the content of a lesson unit issued from the television distance education course Information Technology. It is a mandatory course of the undergraduate program of computer science from Universit&eacute; Laval. Several television programs were used to favor the development of professional abilities needed in the workplace. The first part of this paper summarizes the knowledge that students must acquire. The second part emphasizes the use of television to favor the emergence of the needed professional abilities.
A Two Dimensional Solution of a Rectangular Patch Antenna (2005)

A moment-method solution of a rectangular microstrip radiator is presented. This solution incorporates special treatment of the current singularities at the feed point and at the edges of the patch. A Two-dimensional distribution of the surface current on the microstrip radiator is obtained by a fast convergent computational procedure. A comprehensive set of computed results is shown and discussed.
Active learning for classification of remote sensing images (2009)

This paper presents an analysis of active learning techniques for the classification of remote sensing images and proposes a novel active learning method based on support vector machines (SVMs). The proposed method exploits a query function for the inclusion of batches of unlabeled samples in the training set, which is based on the evaluation of two criteria: uncertainty and diversity. This query function adopts a stochastic approach to the selection of unlabeled samples, which is based on a function of uncertainty estimated from the distribution of errors on the validation set (which is assumed available for the model selection of the SVM classifier). Experimental results carried out on a very high resolution image confirm the effectiveness of the proposed active learning technique, which results more accurate than standard methods.
High-efficiency generation of ultrashort second-harmonic pulses based on the Čerenkov geometry (1994)

Simultaneous phase- and group-velocity-matched generation of ultrashort optical second-harmonic pulses based on a quasi-phase-matched Cerenkov second-harmonic generation scheme is proposed. We compare our scheme with other schemes with respect to its ability to achieve high conversion efficiency, its enhancement with respect to cw second-harmonic generation, and its sensitivity to waveguide-period fluctuation; ion-exchanged KTP and LiNbO(3) waveguides are considered in the evaluation. We believe our proposed scheme is easy to implement, and there is no constraint on crystal length in achieving high efficiency as well as in preserving an ultrashort pulse width. 100% efficiency is potentially obtainable from sufficiently long crystals.
Unsupervised prosodic phrase boundary labeling of Mandarin speech synthesis database using context-dependent HMM (2013)

In this paper, an automatic and unsupervised method based on context-dependent hidden Markov model (CD-HMM) is proposed for labeling the phrase boundary positions of a Mandarin speech synthesis database. The initial phrase boundary labels are predicted by clustering the durations of the pauses between every two prosodic words in an unsupervised way. Then, the CD-HMMs for the spectrum, F0 and phone duration are estimated by a means similar to the HMM-based parametric speech synthesis using the initial phrase boundary labels. These labels are further updated by Viterbi decoding under the maximum likelihood criterion given the acoustic feature sequences and the trained CD-HMMs. The model training and Viterbi decoding procedures are conducted iteratively until convergence. Experimental results on a Mandarin speech synthesis database show that this method is able to label the phrase boundary positions much more accurately than the text-analysis-based method without requiring any manually labeled training data. The unit selection speech synthesis system constructed using the phrase boundary labels generated by our proposed method achieves similar performance to that using the manual labels.
A New Approach to Pruning Volterra Models for Power Amplifiers (2010)

The objective of this paper is to present an approach to behavioral modeling that can be applied to predict the nonlinear response of power amplifiers with memory. Starting with the discrete-time, complex-baseband full Volterra model, we define a novel methodology that retains only radial branches that can be implemented with one-dimensional finite impulse response filters. This model is subsequently simplified by selecting a subset of directions using an ad hoc procedure. Both models are evaluated in terms of accuracy in the time and frequency domains and complexity, and are compared with other models described in the literature. The evaluation is conducted using a low-voltage silicon RF driver amplifier and a 5-W PA, which are characterized at different levels with diverse modulation formats, including wideband code-division multiple-access (WCDMA) and orthogonal frequency-division multiplexed (OFDM) signals. In all cases, comparison of the measured and simulated responses confirms the effectiveness of the proposed approach.
자료 : 우리나라의 고농서 - II. 화본과작물의 (禾本科作物) 종류와 품종의 변천 ( 1492 - 1886 ) - (1988)

古農書에 나타난 禾本科作物의 種類, 各 禾本科作物別 品種名, 그리고 그 品種의 變遷過程을 古農書에서 살펴본바 그 結果를 다음과 같이 要約할 수 있다.
1. 우리나라 古農書 230種中 農業總書라고 할 수 있는 綜合農書는 53種이었으며, 各種 禾本科作物에 대하여 記錄하고 있는 古農書는 25種이었다.
2. 이들 古農書中 1680年 以前 發刊된 農書에는 벼, 보리, 밀, 기장, 조, 피, 수수의 7個 作物이 나타나 있었고, 올무(薏苡)는 1689年의 穗經增集 以後의 農書에, 옥수수는 1787年의 本史 以後의 農書에 나타나 있었으며, 귀리(燕麥, 耳麥, 雀麥)는 農政會要(1830年 刊)에 나타나 있으나 그 栽培는 그보다 훨씬 앞선 것으로 믿어진다. 따라서 古農書에 나타난 禾本科 作物의 種類는 10가지가 된다.
3. 禾本科作物의 栽培歷史를 보면, 보리, 기장, 조, 피, 벼 등은 三國時代 以前부터 栽培된 오랜 作物이었고, 수수는 高麗時代에, 올무와 옥수수는 朝鮮朝에 들어서 導入된 作物이라고 보이며, 귀리는 그 記錄은 늦으나 그 栽培歷史는 수수보다 긴 作物로 보인다.
4. 禾本科作物中 올무와 귀리에 대하여는 品種名을 記綠한 古農書는 찾아볼 수 없었고, 벼, 보리, 밀, 기장, 조, 피, 수수의 品種名과 그 特性을 記錄하고 있는 古農書가 各各 11-13種이나 되었으며, 옥수수의 品種은 2가지의 農書에 靑白紅 3種이 記錄되어 있다.
5. 大體로 各 作物別 品種數는 時代에 따라 增加한 것을 볼 수 있었고, 品種數가 第一많은 것은 벼로서 2個品種(1492年), 27個品種(1492年), 32個品種(1771年), 169個品種(1825年), 170個品種(1842-45年)으로 增加되었으며, 다음으로 조 48個品種 등 그 品種數가 매우 많이 記錄되어 있다.
6. 보리, 밀, 기장, 피, 수수 등의 品種名도 10餘種의 古農書에 나타나 있으나 그 品種名의 語源은 衿陽雜錄을 비롯하였고, 山林經濟, 攷事新書에서 多少 修正되었거나 追加되었으며, 杏蒲志와 林園經濟志에서 綜合되고 있다.
7. 古農書 中 禾本料作物의 品種을 理解하는데는 衿陽雜錄을 비롯하여 山林經濟, 增補山林經濟, 考事新書, 海東農書, 杏蒲志, 林園經濟志 등이 빼놓을 수 없는 貴重한 古農書라는 것을 알 수 있었다.
The oxidation of tyramine and related compounds by peroxidase (1954)

Thesis (Ph.D.) Massachusetts Institute of Technology. Dept. of Biology, 1954.
Presence and Distribution of Lithium in Borate Deposits and Some Recent Lake Waters of West-Central Turkey (2004)

The presence and distribution of lithium, which is used in a variety of applications in current technology and will be a strategic component in near future technology, has been investigated within the scope of some of Turkey's borate and non-borate Neogene basins and recent lakes. Clay samples from the Turkish borate deposits, Soma lignite basin, and Beypazari trona basin, and water samples from Acigöl, Salda, Yarisçi, Burdur, Egirdir, Tersakan, Bolluk, Karapinar (Acigöl), and Tuzgölü lakes were studied. Analytical results show that the lithium values obtained from clays of borate deposits vary between 0.17 and 0.58% Li2O, and lake water samples contain between 0.30 and 325 mg/l Li+. Lithium is mostly bounded in the clay minerals at the borate deposits. While, the Beypazari trona deposit has lithium between 10 and 46 ppm, the Soma lignite basin does not contain lithium. Therefore, lithium is mainly related to evaporatic formations. These lithium amounts indicate that both the waters of Tuzgölü lake and the clays associated with borate deposits are potential lithium resources, and that they may be considered for economic use in the near future. In western Turkey, geothermal sources mostly depend on the graben faulting system; they also contain minor amounts of lithium.
Preventive Tympanoplasty in Children (1995)

Educational objectives : To know about early structural changes in the tympanic membrane that may lead to retractions pockets and cholesteatoma formation and to identify preventive surgical possibilities to avoid further structural changes in the tympanic membrane.
Solid‐State NMR Studies of Pharmaceutical Systems (2008)

Abstract High‐and low‐resolution solid‐state nuclear magnetic resonance (SSNMR) applications to the study of pharmaceuticals are reviewed. Examples are shown involving the use of mono‐and bidimensional SSNMR techniques based on different nuclear interactions and the measurement of several nuclear parameters, such as chemical shifts, line widths, and relaxation times (T1, T2, T1ρ). The systems investigated include pure active pharmaceutical ingredients (APIs), substances used as drug excipients, and solid dispersions formed by APIs and excipients, up to final drug formulations. The most important aspects treated concern structural, dynamic, and morphological properties, and, in particular, identification, characterization, and quantitation of polymorphs and related forms, conformational and crystalline packing behavior, amorphous phase properties and stability, effects of drug processing, molecular motions, API‐excipient and excipient‐excipient chemical and physical interactions, and phase mixing in heterophasic systems.
Evaluation of second-order hyperpolarizabilities for systems with low-energy double transitions by the three-level model (1987)

Second-order hyperpolarizabilities have been calculated by the three-level model for systems having low-energy double transitions. In the three-level model, the second excited state, in addition to the first excited and ground states, is explicitly taken into account. The second-order hyperpolarizabilities calculated by the three-level model gave excellent agreement with the observed values determined by the dc induced second harmonic generation technique, for 4-aminostilbene, p-nitroaniline, and 2-methyl-4-nitroaniline.
Enhance The Design Of LTCC RF Modules (2003)

The use of advanced software tools allows accurate modeling and simulation of high-performance, miniature LTCC circuitry with integrated active and passive components.
Binding of Extracellular Maspin to β1 Integrins Inhibits Vascular Smooth Muscle Cell Migration (2009)

Maspin is a serpin that has multiple effects on cell behavior, including inhibition of migration. How maspin mediates these diverse effects remains unclear, as it is devoid of protease inhibitory activity. We have previously shown that maspin rapidly inhibits the migration of vascular smooth muscle cells (VSMC), suggesting the involvement of direct interactions with cell surface proteins. Here, using immunofluorescence microscopy, we demonstrate that maspin binds specifically to the surface of VSMC in the dedifferentiated, but not the differentiated, phenotype. Ligand blotting of VSMC lysates revealed the presence of several maspin-binding proteins, with a protein of 150 kDa differentially expressed between the two VSMC phenotypes. Western blotting suggested that this protein was the beta1 integrin subunit, and subsequently both alpha3beta1 and alpha5beta1, but not alphavbeta3, were shown to associate with maspin by coimmunoprecipitation. Specific binding of these integrins was also observed using maspin-affinity chromatography, using HT1080 cell lysates. Direct binding of maspin to alpha5beta1 was confirmed using a recombinant alpha5beta1-Fc fusion protein. Using conformation-dependent anti-beta1 antibodies, maspin binding to VSMC was found to lead to a decrease in the activation status of the integrin. The functional involvement of alpha5beta1 in mediating the effect of maspin was established by the inhibition of migration of CHO cells overexpressing human alpha5 integrin, but not those lacking alpha5 expression. Our observations suggest that maspin engages in specific interactions with a limited number of integrins on VSMC, leading to their inactivation, and that these interactions are responsible for the effects of maspin in the pericellular environment.