gebhart/patrepeval huggingface dataset:
Stereoselectivity and Relative Reactivity in the Reaction of Organotitanium and ‐zirconium Reagents with Carbonyl Compounds (1982)

Abstract The complete manuscript of this communication appears in: Angew. Chem. Suppl. 1982 , 257. DOI: 10.1002/anie.198202570
Formation d'un biofilm chez Pseudomonas aeruginosa : Le système Pel, un système putatif de synthèse et d'export d'un polysaccharide impliqué dans le processus d'adhérence (2007)

Chez Pseudomonas aeruginosa, une bacterie gram-negative pathogene opportuniste de l’homme, le biofilm est souvent a l’origine d’infections nosocomiales et d’infections chroniques notamment chez les patients atteints de mucoviscidose. Comprendre comment le biofilm se construit et perennise l’implantation bacterienne est une etape essentielle dans la mise en oeuvre de strategies visant a inhiber et/ou eradiquer cette communaute bacterienne. Mon travail de these a consiste en l’identification de genes impliques dans l’attachement initial de P. Aeruginosa a une surface. Dans ce but, un crible in vitro a ete entrepris et nous avons ainsi identifie un locus de 7 genes, baptises pelA-G (pellicule) par Friedman et Kolter, les co-decouvreurs de ces genes. L’etude des genes pel a permis de confirmer que chacun d’eux est implique au cours des phases d’attachement precoces et tardives. Pour leur part, Friedman et Kolter ont caracterise l’implication des genes pel dans la formation d’une pellicule a l’interface air/liquide d’une culture stagnante. La caracterisation des phenotypes d’une mutation pel a permis de definir que les genes pel sont responsables de la production d’un exopolysaccharide (EPS). Nous proposons que les proteines codees par les genes pel assurent la synthese et l’export de cet EPS nomme PEL. En effet, parmi les proteines Pel, PelF semble etre une glycosyltransferase, PelG un transporteur de polysaccharide (PST) et PelC un membre de la famille OMA (outer membrane auxiliary), proteines impliquees dans l’export de polysaccharides a travers la membrane externe. Enfin, l’etude de l’expression des genes pel indique qu’elle n’est pas constitutive mais soumise a un reseau complexe de regulation mettant en jeu au moins trois senseurs, GacS, RetS et LadS, qui regulent, de facon antagoniste et en fonction des conditions environnementales, des modes d’infection differents faisant intervenir la cytotoxicite plutot que le developpement d’un biofilm.
Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity (2015)

Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's disease (PD). The efficacy is believed to be dependent on pedaling rate, with rates above the subjects' voluntary exercise rates being most beneficial. In this study, we use functional connectivity magnetic resonance imaging (MRI) to further elucidate the mechanism underlying this effect. Twenty-seven PD patients were randomized to complete 8 weeks of forced-rate exercise (FE) or voluntary-rate exercise (VE). Exercise was delivered using a specialized stationary bicycle, which can augment patients' voluntary exercise rates. The FE group received assistance from the cycle. Imaging was conducted at baseline, end of therapy, and after 4 weeks of follow-up. Functional connectivity (FC) was determined via seed-based correlation analysis, using activation-based seeds in the primary motor cortex (M1). The change in FC after exercise was compared using linear correlation with pedaling rate. Results of the correlation analysis showed a strong positive correlation between pedaling rate and change in FC from the most affected M1 to the ipsilateral thalamus. This effect persisted after 4 weeks of follow-up. These results indicate that a plausible mechanism for the therapeutic efficacy of high-rate exercise in PD is that it improves thalamo-cortical connectivity.
Comparison of surface techniques for the discrimination of polymorphs (2016)

Nanoindentation and atomic force microscopy (AFM) are two surface techniques used to study mechanical and surface properties of solids. One area where these two approaches are not widely employed, however, is the discrimination of polymorphs, for which methods such as single crystal XRD, PXRD, spectroscopy, DSC and ss-NMR are more commonly used. The main advantage of the surface techniques is that a single micron-sized crystal is sufficient for analysis. Here we discuss the application of nanoindentation, AFM height imaging and force–distance measurements to distinguish two polymorphs of a pharmaceutical cocrystal containing caffeine and glutaric acid.
Precise frequency measurements of ^127I_2 lines in the wavelength region 750–780 nm (2010)

High precision frequency measurements of 127I2 hyperfine transitions in the wavelength range between 750 and 780 nm were performed employing an optical frequency comb. A Ti:sapphire laser is frequency stabilized to a hyperfine component of I2 using a Doppler-free frequency modulation technique, and an optical frequency comb is used to measure its frequency precisely. Improved absolute frequencies of 27 hyperfine transitions between 750 and 780 nm of the bands (0–12) and (0–13) of B 3Π0u+–X 1Σ+g system of I2 are presented. The relative uncertainty of the measurement is a few times 10−10, limited by the frequency instability of the iodine-stabilized laser. The frequencies are compared to the predicted frequencies using the model description of [Eur. Phys. J. D28, 199 (2004)], which yields differences larger than expected. An improved model is developed for the range from 755 to 815 nm for the prediction of lines with an error limit of the absolute frequency less than 0.2 MHz.
DNase I disinhibition is predominantly associated with actin hyperpolymerization after traumatic brain injury (2001)

To elucidate a role for the cytoskeletal protein actin in post‐traumatic apoptotic cell death, the ability of actin‐containing tissue extracts to inhibit exogenous DNase I was evaluated. In addition, cortical, hippocampal and thalamic extracts were examined for caspase‐mediated actin cleavage and changes in actin polymerization state. Rats were anesthetized, subjected to lateral fluid percussion brain injury of moderate severity, and euthanized at 1 h, 6 h, 24 h, 1 week or 3 weeks post‐injury ( n = 3 per time‐point). Tissue extracts from all brain regions of sham (uninjured) animals inhibited exogenous DNase I activity to a significant extent. However, inhibition of DNase I was significantly reduced at 1 h and 6 h in the injured hippocampus, and at 1 h, 6 h and 3 weeks in the thalamus. DNase I in cortical extracts of all injured animals was inhibited to a similar extent as that in uninjured animals. Actin fragments consistent with caspase‐mediated proteolysis were observed in immunoblots of the injured hippocampus and thalamus at 1 h and 24 h, respectively, and were present up to 3 weeks post‐injury. Transient actin hyperpolymerization was observed at 1 and 6 h post‐injury in the thalamus and hippocampus, while actin depolymerization was observed at 1 and 3 weeks in the cortex and thalamus. Collectively our data suggest that DNase I disinhibition following brain trauma is associated predominantly with actin hyperpolymerization but also with actin depolymerization and concomitant caspase‐mediated actin proteolysis.
Anionic Iron Complexes with a Bond between an Ate-Type Pentacoordinated Germanium and an Iron Atom (2012)

The first stable anionic iron(0) complexes bearing an ate-type pentacoordinated germanium(IV) ligand were synthesized. The X-ray crystallographic analysis shows trigonal-bipyramidal and piano-stool geometries of germanium and iron, respectively. The complexes have moderately electron-rich iron centers and polar Ge–Fe bonds which can be cleaved by oxidation.
TNF-alpha and doxorubicin in hyperthermic perfusion for limb sarcomas (1996)

Eighteen patients, subdivided into groups of three, were perfused for 90 min with escalating doses of TNF-alpha (0.5-3.3 mg) and standard doses of doxorubicin (bolus 0.7-1.4 mg/kg) at a tumor temperature of at least 41 degrees C, with the aim to ascertain the maximum tolerable dose (MTD) and the activity of TNF-alpha combined with doxorubicin in hyperthermic antiblastic perfusion (HAP) for patients with limb sarcomas, candidates for amputation. Tumor response was assessed both pathologically and radiologically. Severe systemic toxicity (WHO) was observed in only 2 patients. Locoregional toxicity (Wieberdink's) was grade I in 3 patients, grade II or III in 10 and grade IV in 5. A strict correlation between the TNF dosage and the grade of limb reaction was found, grade IV being retrieved only with TNF dose >1 mg and/or muscular temperature >41.5 degrees C. Tumor necrosis was evaluated in 16 patients: in 11 (68.8%) it scored more than 75% while in 5 it was 25 to 75%. Four cases (25%) had 100% tumor histological necrosis. Limb sparing surgery was feasible in 13 (81%). Our findings suggest that this is a well-tolerated and highly active regimen in HAP.
ChemInform Abstract: Mechanism of Action of 2′,5‐Difluoro‐1‐arabinosyluracil. (1983)

Abstract Es wird gezeigt, daß die cytotoxische Wirkung von (Ia) von der Umwandlung in das Phosphat (Ib) abhängig ist.
Cross-talk between α7 nAChR-mediated cholinergic pathway and acylation stimulating protein signaling in 3T3-L1 adipocytes: role of NFκB and STAT3 (2015)

Inflammation is a key feature in adipose tissue, especially in association with obesity comorbidies. The novel adipokine acylation stimulating protein (ASP) is one factor implicated in the inflammatory response. The disruption of the α7 nicotine acetylcholine receptor (α7nAChR), an important component of the endogenous non-neural cholinergic defense system, may exacerbate sustained inflammatory phenotype. We examined cholinergic regulation of ASP-initiated inflammatory response in 3T3-L1 adipocytes. Our results show that preincubation of 3T3-L1 cells with α7nAChR agonist GTS-21 significantly reduces ASP-mediated chemokine MCP-1 secretion, which is regulated though nuclear factor κB (NFκB) and signal transducer and activator of transcription 3 (STAT3). Treatment of 3T3-L1 cells with GTS-21 significantly reduced NFκB activation by DNA binding and STAT3 activation by disturbing post-translational modification.
Stimulation by ACTH<sub>4–10</sub> of nerve fiber regeneration following sciatic nerve crush (1983)

The number of newly formed myelinated nerve fibers was counted in the sciatic and tibial nerves in the rat following sciatic nerve crush. Beginning at days 8 and 14 in the sciatic and tibial nerve, respectively, the number of new myelinated fibers increased steadily and eventually exceeded the original number by 40 and 30%, respectively. This overshoot in nerve fibers was accompanied by the presence of clusters of fibers. Both the overshoot and the clusters disappeared at later stages and returned gradually to normal values within 3 months. Chronic administration of ACTH4-10 to the animals resulted in higher numbers of new myelinated nerve fibers throughout the process of regeneration. This stimulation was most pronounced (a three-fold increase) during the initial stages of regeneration. A higher number of myelinated nerve fibers was also observed in ACTH-treated rats 60 and 96 days after sciatic nerve crush. No changes in diameter of the fibers could be observed. The results are discussed in terms of a stimulation of the number of outgrowing nerve fibers caused by the peptide treatment.
Early events in plant hypersensitive response revealed by IR thermography (2001)

Infrared thermography is used to reveal the establishment of Erwinia amylovora harpin-induced hypersensitive response (HR) in Nicotiana sylvestris leaves. We observed a decrease in temperature (1-2°C) in the harpin infiltrated zone, correlated with an increase in stomatal opening, strongly suggesting that the temperature decrease is due to higher transpiration rate. IRT experiments were conducted in a laboratory environment and could be widely applied for genotype screening and monitoring drug effects.
Design optimization of the of an automotive thermoacoustic air conditioning system (2007)

A comprehensive algorithm has been developed to design and optimize heat-driven thermoacoustic refrigeration (HDTAR)systems. This algorithm is applied to design and optimize a HDTAR capable of providing 30 w of cooling power at 2°C. The computer code DeltaE is used to simulate the device. The HDTAR has the total length of 1.25 m and the cross sectional area of 0.012m 2 . The results indicate that since HDTAR devices utilize the available waste heat from the automotive engine to cool down the automotive interior, even at relatively low efficiency these devices could still reduce the amount of fuel used in the conventional automotive air conditioning systems.
Effects of cognitive demands on postmovement motor cortical deactivation (2006)

Postmovement beta-rebounds induced by different intermovement intervals were investigated using magnetoencephalography in 14 healthy participants to test the hypothesis that postmovement motor cortical deactivation over the primary motor cortex depends on movement-related cognitive demands. Shorter latency and lower amplitude in postmovement beta-rebounds over the contralateral primary motor cortex were noted in the short-movement interval movement (repetitive finger lifting). Greater latency span of postmovement beta-rebounds jittering using single-trial analysis in the long-movement interval movement (discrete finger lifting) was observed. The study elucidates that the temporal interval between two adjacent movements reflecting different degrees of cognitive demands can affect postmovement motor cortical deactivation in terms of postmovement beta-rebounds latency and amplitude, and latency span of postmovement beta-rebounds jittering. Postmovement motor cortical deactivation can reflect cognitive demands in addition to motor and somatosensory processing.
Experimental Full Duplex Simultaneous Transmission of LTE Over a DWDM Directly Modulated RoF System (2013)

2013-2014 > Academic research: refereed > Publication in refereed journal
5′-ABL Gene Deletion on Derivative Chromosome 9 Detected by FISH: Prognostic Significance in CML Patients after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT). (2005)

Abstract BACKGROUND AND OBJECTIVE Large cryptic deletions of the 5′-ABL regions on derivative chromosome 9 can be identified by FISH in 10%–15% of Ph+ CML patients. This abnormality may be associated with unfavorable prognosis with conventional therapies. There is limited data regarding the prognosis of 5′-ABL gene deletion abnormality in recipients of allogeneic HSCT. We performed an analysis of our prospectively collected database to evaluate the prognostic importance of this karyotypic abnormality in HSCT patients. METHODS: Between1989–2004, 24 allogeneic HSCT patients with 5′-ABL gene deletion detected by FISH using ES-BCR/ABL probe were identified. The diagnosis was CML CP1, 16(66.6%), CML CP2, 5(20.8%), CML AP 2(8.3%), CML blastic phase 1(4.1%). Sex ratio: M/F 8/17; median age: 25.06 (14.7–51.9) years. All donors were HLA matched identical sibling. Stem cell source was BM in 15(62.5%), PB in 9(37.5%). Mean CD34 cells x106/kg dose was, BM 5.0 (2.05–7.67), PB 7.18 (1.64–10.71). Conditioning regimen was BU/CY2 in 19, CY/TBI in 4 and FLU/TBI in 1 patient. A second group of 206 Ph+ CML pts was evaluated for comparison. These were patients with CML without 5′-ABL gene deletions that underwent allogeneic SCT from 1989–2004. This group was matched for age, sex, conditioning regimen, type of SCT, stem cell source and HLA matched sibling donors. The diagnosis was CML CP 148(71.8%), CML CP2 37(18.0%) AP 21(10.2%). RESULTS: After a median follow up of 17.5 mths in group 1 (del 9) and 17.05 mths in group 2 (without del 9), relapse occurred in 11/24(45.8%) in group 1 and 48/206(23.3%) in group 2, indicating RFS of 54.2% vs 76.7% respectively (P= .03). A sub-group analysis was made between CML CP1 patients only, between both groups. With 16 patients in group 1 and 148 pts in group 2 with a median FU of 21.5 vs 26.5 mths, the RFS was 7/16(43.7%) vs 118/148 (79.7%) respectively (P=. 001). CONCLUSION Patients with 5′-ABL gene deletions on derivative chromosome 9 have a significantly higher relapse rate even after high dose chemotherapy and allogeneic HSCT as compared to patients without this abnormality. We recommend close monitoring of these patients by RT-PCR to detect early molecular relapse and treatment with DLI and/or Imatinib Mesylate.
Steady and Dynamic Models of Fuel and Air Flow in Carburetors for Small Engines (2005)

This work presents the mathematical model of a complex flow network containing short metering orifices, compressible flow, and two-phase flow in small diameter pipes. It has been developed to study the steady and dynamic flows in a carburetor for small engines. It extends the previously published models by incorporating a detailed review of two-phase flow pressure drop, the effect of the fuel well on the control of air-bleed flow, and dynamic flow. The homogeneous two-phase flow model, which is commonly used in previous models, was compared to an empirical correlation derived from experiments in small pipes and found to be in poor agreement. In order to assess dynamic flow conditions, the model was extended by solving instantaneous one-dimensional Navier-Stokes equations in single-phase pipes. This strategy proved successful in explaining the mixture enrichment seen under pulsating flow conditions. The model was also used to derive a sensitivity analysis of geometries and physical properties of air and fuel.
A survey on spectrum management in cognitive radio networks (2008)

Cognitive radio networks will provide high bandwidth to mobile users via heterogeneous wireless architectures and dynamic spectrum access techniques. However, CR networks impose challenges due to the fluctuating nature of the available spectrum, as well as the diverse QoS requirements of various applications. Spectrum management functions can address these challenges for the realization of this new network paradigm. To provide a better understanding of CR networks, this article presents recent developments and open research issues in spectrum management in CR networks. More specifically, the discussion is focused on the development of CR networks that require no modification of existing networks. First, a brief overview of cognitive radio and the CR network architecture is provided. Then four main challenges of spectrum management are discussed: spectrum sensing, spectrum decision, spectrum sharing, and spectrum mobility.
On shallow-water bottom reverberation angular dependence (2005)

Low-frequency monostatic reverberation data obtained during East China Sea ASIAEX in 2001 using Institute of Ocean Acoustics (Beijing) explosive sources and vertical line-receiving array on ShiYan-3 were analyzed in octave bands from 100–800 Hz to determine bottom-scattering strength dependence on bottom-scattering angle. Several methods for estimating the reverberation directionality spectrum were applied and results compared, employing previously described techniques to estimate transmission loss in the extraction of integrated bottom-scattering strength from reverberation [P. G. Cable et al., J. Acoust. Soc. Am. 112, 2362 (2002)]. In the two higher octave bands, scattering angle dependence for grazing angles below critical was found to be approximately proportional to first power of the sine of scattering angle, while estimation bias errors associated with limited angular resolution obscured the behavior in the lowest octave band. [Work supported by ONR under ASIAEX program.]
Enhancing anonymity via market competition (2004)

Anonymity is an important issue in the cyberspace community. Previous solutions typically rely on a well-defined trust structure - a set of distributed trustees among whom at least a quorum are supposed to be honest. We argue that the establishment of such a distributed trust structure is beyond the scope of technology itself. We propose an institutional framework within which service providers compete to provide high quality anonymity, and users can customize their anonymity according to their personal priorities. The major contribution of this paper is the incorporation of market competition into anonymity system models.
Longevity in Second Life (2010)

User retention is important to the success of online social media, particularly in virtual world settings where users shape one another’s online experience. We study a rich set of variables, including social network and group membership, chatting, and transactions, in order to predict which users will stay and which ones will leave. We find that simple variables directly measuring the intensity and diversity of a user’s interaction with others are most predictive.
ChemInform Abstract: PYRANO HETEROCYCLES PART 1, THE SYNTHESES OF ISOCHROMANS AND THE NOVEL THIENO(3,2‐C)PYRAN, BENZOTHIENO(3,2‐C)PYRAN, BENZOTHIENO(2,3‐C)PYRAN AND PYRANO(4,3‐B)BENZOFURAN SYSTEMS (1975)

Abstract Aus dem Dimethoxy‐phenyläthanol (I) erhält man mit zahlreichen Oxo‐Verbindungen (II) oder ihren Ketalen die 1‐substituierten Isochromane (III).
Flow Behavior of Nanoparticle Stabilized Drilling Fluids and Effect of High Temperature Aging (2011)

Nanoclay and nanosilica were used to stabilize invert emulsion model drilling fluids for HTHP application. Though each nanomaterial can stabilize the emulsion by itself, best properties were obtained when both were used. Yield stress and plastic viscosity were found to be dependent on composition and the hydrophobic/hydrophilic nature of the nanoparticles. Adding barite results in loss of yield stress, however, it can be regained by increasing the nanosilica content. Aging at 225 o C (437 o F) for 96 hrs showed that the nanoparticle stabilized emulsions remain stable with only small changes in rheological properties.
N,N-Dimethyl-2-[7-(methylaminosulfonylmethyl)-1-naphthyl]ethylamine, the Naphthalenic Bioisostere of Sumatriptan (1995)

The title molecule, C16H22N2O2S, is the naphthalenic bioisostere of sumatriptan, a well known agonist of the 5-hydroxytryptamine 5-HT1D receptor. The ethylamine side chain adopts an extended conformation (ac,ap,ap) and its plane is perpendicular to the naphthalene ring plane. This is very similar to that already observed in some analogous indole derivatives.
Mycotoxins in cereal grain. Part IX. Zearalenone and <i>Fusaria</i> in wheat, barley, rye and corn kernels (1983)

Toxigenic Fusaria, producing zearalenone, appeared in 31% of cereal grain samples. However zearalenone was present only in 0.5% of 584 cereal samples assayed during 1979-1981 at level 0.2-1.2 mg/kg. Fungi able to form zearalenone were present mainly in grain collected from breeding stations. Fusarium culmorum was dominant among toxigenic isolates from domestic cereals and yield of zearalenone was up to 700 mg/kg.