gebhart/patrepeval huggingface dataset:
COMT158 polymorphism and hostility (2003)

The main study was designed primarily to compare the clinical effects of four antipsychotics in 157 patients with schizophrenia or schizoaffective disorder. The secondary genetic study, reported here, is based on a subset of 60 patients who consented to genotyping assays. Based on previous work with the catechol-O-methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met-Met homozygotes would be more hostile than the heterozygotes and the Val-Val homozygotes. Hostility ratings at baseline were used to test this hypothesis. The Met-Met homozygotes (N = 7) were found to have significantly higher levels of hostility than the other patients (N = 53). The hypothesis was thus supported. The finding should be replicated in a larger sample.
Automatic defect localization in VLSI circuits: A fusion approach based on the Dempster-Shafer theory (2017)

Defect localization in Very Large Integration Circuits (VLSI) requires to use multi-sensor information such as electrical waveforms, emission microscopy images and frequency mapping in order to detect, localize and identify the failure. Each sensor provides a specific kind of feature modeling the evidence. Thus, the defect localization in VLSI can be summarized as a problem of data fusion with heterogeneous and imprecise information. This study illustrates how to reproduce the human decision for modeling and fusing the different multi-sensor features by using the Demspter-Shafer theory. We propose not only an automatic decision rule for mass functions computing but also confidence intervals to quantify the final decision and to bring a decision help for the analysts expertise. Finally, a case of study is reported to attest the expert decision reproducibility.
Production of Microbial Glycolipids (1999)

Some microorganisms are able to convert preferably carbohydrates, n-alkanes (C10 to C20), and triglycerides (fatty acids of C10 to C22) into glycolipids. The carbon sources may be used separately or in combination with each other. As for biosynthetic pathways, these include both degradation and new synthesis of sugar lipids, as well as direct incorporation, elongation, or modification of precursor molecules. Reviews recently published are those of Desai and Desai (1) and Lang and Wagner (2,3), indicating that in general the following patterns of glycolipid production by microbial cultivation are possible:
ChemInform Abstract: CHEMIE GESPANNTER BINDUNGEN 25. MITT. RK. TRANS‐VERKNUEPFTER CYCLOPROPANE, SYNTH. UND SOLVOLYSE DER EPIMEREN 2‐HYDROXY‐TRANS‐BICYCLO(6,1,0)NONAN‐P‐NITROBENZOATE (1971)

Abstract Die Kinetik der Solvolyse der epimeren Nitrobenzoate (Ib)‐(IVb) der Alkohole (Ia)‐(IVa), welche nach bereits bekannten Methoden [im Falle (Ia) und (IIa) modifiziert] synthetisiert werden, in Wasser‐Dioxan (30 : 70) wird untersucht.
Fracture and Strength of Mechanically Fastened Joint in Multi-Axial Flat Braided Composite. (1992)

Braided fabrics are useful as one of the techniques in realizing the concept of near-net shape in the reinforcement configuration of composite materials. When structural members are connected with other members, the mechanically fastened joint is well known as one of the simplest method. It has been confirmed in our previous paper that braided flat bar with a braided hole in which the fibers continuously orient, has high joint performance with small joint geometry. The effect of middle-end-fibers which are one of the braiding techniques is discussed in this paper. It is proved that performance of mechanically fastened joints with braiding structure containing middle-end-fibers is superior to no middle-end-fibers. Moreover, the effect of the continuous fibers at the sides of the flat braid is also discussed. It is clear that these continuous fibers are effective to raise joint strength.
Peptic Ulcer Guideline Team (2005)

■ Clinical approach. Ulcers are caused by an infection of a bacterium known as Helicobacter pylori or H. pylori. Eradication of HP infection alters the natural history of peptic ulcer disease. Successful eradication reduces PUD recurrence rate from 90% to < 5% per year [A*]. PUD generally does not recur in the successfully treated patient unless nonsteroidal anti-inflammatory drug (NSAID) use is present.
Proton-implanted KNbO3 exhibits net photorefractive gain at telecommunication wavelengths up to 1550 nm (1996)

Photorefractive crystals such as KnbO 3 , BaTiO 3 , and Sr 1-x Ba x Nb 2 O 6 are very promising for all-optical signal processing. Attention has been drawn to the extension of the photorefractive response up to telecommunication wavelengths. Recently it was shown that ion-irradiation of KNbO 3 and BaTiO 3 improves photorefractive response time and gain due to a significant increase of the trap density compared to the virgin crystal 1,2 . Quite large photorefractive gain at 830 nm was reported in He + ion-implanted Fe-doped KNbO 3 waveguides together with a significant decrease in the response time 3 .
Assembly of a chemically synthesized peptide of Escherichia coli type 1 fimbriae into fimbria-like antigenic structures (1987)

Escherichia coli type 1 fimbriae are composed of subunits, each of which comprises 158 amino acids. We synthesized a copy of a 13-residue peptide, located near the NH2 terminus of the fimbrial subunit, that assumed some of the properties of type 1 fimbriae. At pH 5.5 the synthetic peptide autoassembled into fibrillar structures that resembled type 1 fimbriae except that they appeared less rigid and rodlike. A quaternary structure-specific monoclonal antibody against type 1 fimbriae recognized the synthetic peptide in the assembled but not the unassembled state. Furthermore, when the synthetic peptide was injected in its fimbrial conformation into rabbits, it evoked antibodies that reacted with type 1 fimbriae isolated from E. coli.
Exploring wearable ambient displays for social awareness (2006)

Mobile phones represent not only a means of communication, but an increasingly omnipresent computing platform, enabling diverse modes of communication including ambient displays that are tied to bodies and social groups, rather than physical environments. As an example of such a display, we present Damage, a prototype device for mobile ambient awareness of a social group, and discuss design considerations for such devices.
Association of Urokinase-type Plasminogen Activator with Asthma and Atopy (2007)

This suggests a role for the uPA pathway in the pathogenesis of the disease.
High-rate maximum runlength constrained coding schemes using nibble replacement (2011)

We will present simple and systematic constructions of high-rate binary maximum runlength constrained codes. The new construction has the virtue that large look-up tables for encoding and decoding are not required.
Predictive Flow-Aware Networks (2011)

Admission control routine in Flow-Aware Networks (FAN) may lead to severe fair rate degradation, which negatively impacts the performance of ongoing flows. To mitigate the problem, a predictive approach is proposed in this paper. Instead of waiting for the congestion to occur, proper admission control actions are performed when the system approaches the congestion state. After each network measurement, by analyzing the trend, the next values are predicted and actions are taken based on the predicted values. The proposed mechanism can be simultaneously used with the limitation mechanism providing a considerable performance increase.
On the Accuracy of Bounded Rationality: How Far from Optimal Is Fast and Frugal? (2005)

Fast and frugal heuristics are well studied models of bounded rationality. Psychological research has proposed the take-the-best heuristic as a successful strategy in decision making with limited resources. Take-thebest searches for a sufficiently good ordering of cues (features) in a task where objects are to be compared lexicographically. We investigate the complexity of the problem of approximating optimal cue permutations for lexicographic strategies. We show that no efficient algorithm can approximate the optimum to within any constant factor, if P != NP. We further consider a greedy approach for building lexicographic strategies and derive tight bounds for the performance ratio of a new and simple algorithm. This algorithm is proven to perform better than take-the-best.
Photomultiplier Reception of Satellite Beacon Flashes (1969)

Experiments have been performed on the electrooptical detection of flashes from satellite-borne beacons for the purposes of establishing the time of flash at the observing site, measurement of received pulse shape, and relative measurement of received energy. Initial observations have been made of the beacons carried by the geodetic satellite GEOS-B. Time of flash has been obtained to a precision of 0.1 msec. Pulse shape and energy measurements have been made for various slant ranges and at various voltages on the photomultiplier circuits. Continued testing is directed toward microsecond timing of flash reception.
Adoptive T Cell Therapy Strategies for Viral Infections in Patients Receiving Haematopoietic Stem Cell Transplantation (2019)

Adverse outcomes following virus-associated disease in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT) have encouraged strategies to control viral reactivation in immunosuppressed patients. However, despite timely treatment with antiviral medication, some viral infections remain refractory to treatment, which hampers outcomes after HSCT, and are responsible for a high proportion of transplant-related morbidity and mortality. Adoptive transfer of donor-derived lymphocytes aims to improve cellular immunity and to prevent or treat viral diseases after HSCT. Early reports described the feasibility of transferring nonspecific lymphocytes from donors, which led to the development of cell therapy approaches based on virus-specific T cells, allowing a targeted treatment of infections, while limiting adverse events such as graft versus host disease (GvHD). Both expansion and direct selection techniques have yielded comparable results in terms of efficacy (around 70⁻80%), but efficacy is difficult to predict for individual cases. Generating bespoke products for each donor⁻recipient pair can be expensive, and there remains the major obstacle of generating products from seronegative or poorly responsive donors. More recent studies have focused on the feasibility of collecting and infusing partially matched third-party virus-specific T cells, reporting response rates of 60⁻70%. Future development of this approach will involve the broadening of applicability to multiple viruses, the optimization and cost-control of manufacturing, larger multicentred efficacy trials, and finally the creation of cell banks that can provide prompt access to virus-specific cellular product. The aim of this review is to summarise present knowledge on adoptive T cell manufacturing, efficacy and potential future developments.
Site‐Selective CH Borylation of Quinolines at the C8 Position Catalyzed by a Silica‐Supported Phosphane–Iridium System (2013)

Site-selective C-H borylation of quinoline derivatives at the C8 position has been achieved by using a heterogeneous Ir catalyst system based on a silica-supported cage-type monophosphane ligand SMAP. The efficient synthesis of a corticotropin-releasing factor1 (CRF1) receptor antagonist based on a late-stage C-H borylation strategy demonstrates the utility of the C8 borylation reaction.
A trace abstraction approach for host-based anomaly detection (2015)

High false alarm rates and execution times are among the key issues in host-based anomaly detection systems. In this paper, we investigate the use of trace abstraction techniques for reducing the execution time of anomaly detectors while keeping the same accuracy. The key idea is to represent system call traces as traces of kernel module interactions and use the resulting abstract traces as input to known anomaly detection techniques, such as STIDE (the Sequence Time-Delay Embedding) and HMM (Hidden Markov Models). We performed experiments on three datasets, namely, the traditional UNM dataset as well as two modern datasets, Firefox and ADFA-LD. The results show that kernel module traces can lead to similar or fewer false alarms and considerably smaller execution times compared to raw system call traces for host-based anomaly detection systems.
Operation of Lorentz-Force MEMS Magnetometers With a Frequency Offset Between Driving Current and Mechanical Resonance (2013)

The paper discusses the operation of Lorentz-force-based microelectromechanical magnetometers at a driving-current frequency slightly lower than the device resonance frequency. Among the advantages with respect to operation at resonance, there are a higher achievable signal to noise ratio (thanks to the lower permitted pressure and damping coefficient, which have now no influence on the maximum sensing bandwidth) and the possibility of driving more magnetometers in series through a single current source, enabling the fabrication of low-power 3-axis magnetic field sensors. A partial drawback is represented by a loss in gain-factor. Experimental results obtained on a sample device confirm the trade-off between gain-factor decrease and bandwidth increase. Guidelines for an optimized design of Lorentz force magnetometers are given together with a comparison with other state-of-the-art technologies through the introduction of a figure of merit. In particular, it is shown how Lorentz force devices can reach better performance in terms of minimum detectable magnetic flux density per unit current consumption and bandwidth.
New method for the discrimination of single-source events in heavy-ion collisions (2000)

This paper introduces a new method for the selection of central single-source events, based on classical multivariate techniques. The resulting discriminating variable is shown to be valid for different hypotheses on the nuclear source deexcitation mechanism. It enables the selection of events which are representative of the whole set of single-source events. Application to the Ni+Ni at 32A MeV system measured with the INDRA multidetector has allowed the determination of the fusion probability as a function of the impact parameter and the evaluation of the corresponding cross section.
Thermal Analyses of a Multilayer with Embedded Vertical-Cavity Surface Emitting Lasers (2007)

Significant progress of industrial PWB technology can be expected in the near future due to the need of a solution for continuously increasing data rates between components on board level. One promising solution on the base of optical data lines is introduced whereby a VCSEL is used as transmitter embedded in an optical polymer in which a waveguide is "written" by laser processing the polymer with a TPA process. A demonstrator board has been fabricated and a thermal feasibility under operation conditions is studied to prove the suitability of this technology for industrial application. According to our investigation even under worst case condition a thermal resistance of less than 0.5 K per milliwatt seams realistic.
Understanding Performance Gains of Accelerator-Rich Architectures (2019)

The power and utilization walls in today's processors have led to a recent focus on accelerator-rich architectures (ARAs), which include a sea of customized accelerators with orders-of-magnitude performance and energy gains. Meanwhile, some researchers wonder how the reported large gains are achieved, considering that ARAs use a similar memory hierarchy to conventional processors. In this paper we conduct an in-depth analysis of ARAs with a key focus on the memory access component not studied in prior work. Based on our experimental results, we observe that ARAs achieve performance gains from both computation and memory access customization. For computation customization, ARAs not only exploit the coarse-grained parallelism as conventional processors do, but also uniquely customize a deep processing pipeline without instruction overhead. For memory access customization, ARAs exploit a tile-based read-compute-write execution model that both reduces the number of memory accesses and improves the memory-level parallelism (MLP). We quantitatively evaluate the performance impact of such factors and surprisingly find that 1) memory access customization plays a bigger role in the performance improvement than computation customization, and 2) the dominating contributor to the ARA memory access performance improvement is the improved MLP rather than the widely-expected memory access reduction. Indeed, we find that existing GPU accelerators also benefit from the improved MLP through different techniques. The unique customized deep processing pipeline of ARAs further provide an average of 1.4x speedup over GPUs. Moreover, on average, ARAs are 18x more energy efficient over GPUs. We hope this understanding can help future ARA design and adoption.
Incremental Temporal Logic Synthesis of Control Policies for Robots Interacting with Dynamic Agents (2012)

We consider the synthesis of control policies from temporal logic specifications for robots that interact with multiple dynamic environment agents. Each environment agent is modeled by a Markov chain whereas the robot is modeled by a finite transition system (in the deterministic case) or Markov decision process (in the stochastic case). Existing results in probabilistic verification are adapted to solve the synthesis problem. To partially address the state explosion issue, we propose an incremental approach where only a small subset of environment agents is incorporated in the synthesis procedure initially and more agents are successively added until we hit the constraints on computational resources. Our algorithm runs in an anytime fashion where the probability that the robot satisfies its specification increases as the algorithm progresses.
RAPID CARBAMAZEPINE SUSPENSION LOADING IN THE CRITICALLY ILL NEUROSURGICAL PATIENT (1996)

O'Neil, Michael G. PharmD; Diggins, Daniel PharmD; Harvey, Susan C. MD; Patel, Sunil MD Author Information
The Development of English <i>t, d</i>, in North Indian Languages (1926)

It is often said that Portuguese dental t, d , remain dental in India and that English alveolar t, d , become cerebral. It would follow that words like kaptān and botal and haspatāl , usually stated to be from English, must be Portuguese. The question cannot be disposed of so simply; there seem to have been cross influences at work, and sometimes there are different forms of the same word. See S. R. Dalgado's works passim for valuable suggestions.
Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes (2018)

The drimane sesquiterpenoids drimenin, cinnamolide, dendocarbin A, and polygodial were purified from the Canelo tree ( Drimys winteri) and chemically characterized by spectroscopic methods. The pharmacological activity of these natural compounds were determined on hα4β2, hα3β4, and hα7 nicotinic acetylcholine receptors (AChRs) by Ca<sup>2+</sup> influx measurements. The results established that drimane sesquiterpenoids inhibit AChRs with the following selectivity: hα4β2 > hα3β4 > hα7. In the case of hα4β2 AChRs, the following potency rank order was determined (IC<sub>50</sub>'s in μM): drimenin (0.97 ± 0.35) > cinnamolide (1.57 ± 0.36) > polygodial (62.5 ± 19.9) ≫ dendocarbin A (no activity). To determine putative structural features underlying the differences in inhibitory potency at hα4β2 AChRs, additional structure-activity relationship and molecular docking experiments were performed. The Ca<sup>2+</sup> influx and structural results supported a noncompetitive mechanism of inhibition, where drimenin interacted with luminal and nonluminal (TMD-β2 intrasubunit) sites. The structure-activity relationship results, i.e., the lower the ligand polarity, the higher the inhibitory potency, supported the nonluminal interaction. Ligand binding to both sites might inhibit the hα4β2 AChR by a cooperative mechanism, as shown experimentally ( n<sub>H</sub> > 1). Drimenin could be used as a molecular scaffold for the development of more potent inhibitors with higher selectivity for the hα4β2 AChR.
Quelques dates historiques (1914)

Klein Henri. Quelques dates historiques. In: Les Feuillets d'El-Djezaïr, volume 7, 1914. Visites et excursions des années 1912 et 1913. Monographies. Écrits divers. pp. 109-141.
The World Wide Telescope: An Archetype for Online Science (2002)

Abstract: Most scientific data will never be directly examined by scientists; rather it will be put into online databases where it will be analyzed and summarized by computer programs. Scientists increasingly see their instruments through online scientific archives and analysis tools, rather than examining the raw data. Today this analysis is primarily driven by scientists asking queries, but scientific archives are becoming active databases that self-organize and recognize interesting and anomalous facts as data arrives. In some fields, data from many different archives can be cross-correlated to produce new insights. Astronomy presents an excellent example of these trends; and, federating Astronomy archives presents interesting challenges for computer scientists.
Security and forensic computing: intrusion detection systems. (2010)

2INTRUSION DETECTION SYSTEMS502.1Introduction502.2Types of intrusion532.3Attack patterns542.4Host/network-based intrusion detection552.5Placement of the IDS572.6SNORT592.7Example rules612.8Running Snort672.9User, machine and network profiling732.10Honey pots742.11In-line and out-of-line IDSs762.12False and true772.13Customized Agent-based IDS782.14Tutorial792.15Software tutorial81
Application of bayesian non-negative source separation to mixture analysis in spectroscopy (2004)

Abstract. In this paper we present an application of Bayesian non-negative source separation to the analysis of spectral mixtures obtained from the analysis of multicomponent substances. The processing aims are formalized as a non-negative source separation problem. The proposed Bayesian inference for the analysis is introduced and the main steps of the estimation algorithm are outlined. Finally, some results obtained with simulated and experimental data are presented. PROBLEM STATEMENT The analysis of multicomponent chemical substances using spectroscopic techniques yields data which are mixtures of the pure component spectra. The processing aims at identifying the unknown pure components and determining their concentrations [1]. According to Beer-Lambert-Bouguer law [2], the mixing model is linear instantaneous Xi(νk) = n ∑ A (i, j)S j(νk)+Ei(νk), for k = 1,...,N, (1) j=1 where Xi(νk), S j(νk) represent respectively the i-th observation and the j-th pure component