gebhart/patrepeval huggingface dataset:
Effects of highly hygroscopic excipients on the hydrolysis of simvastatin in tablet at high relative humidity (2012)

Effects of highly hygroscopic sorbitol, citric acid, sodium carboxymethyl cellulose or polyvinylpolypyrrolidone, on the hydrolysis of simvastatin in tablets at 25°/90% RH were studied. The simvastatin tablets were prepared by direct powder compression. Simvastatin and its hydrolyte, simvastatin acid, were quantitatively analysed by high performance liquid chromotography. The hygroscopicity, water swelling ratio, water solubility and pH of the four hygroscopic excipients were investigated. During the investigation period, the weight gain of sorbitol or citric acid increased faster than that of polyvinylpolypyrrolidone or sodium carboxymethyl cellulose at 25°/90% RH, accordingly, the moisture sorption of the tablets containing citric acid or sorbitol (T-3 or T-6) were more than that of the tablets containing sodium carboxymethyl cellulose or polyvinylpolypyrrolidone (T-4 or T-5). The increase of simvastatin acid content with time at 25°/90% RH for the tablets was in the following order: T-6 < T-4 < T-3 < T-5. The effects of the four excipients on the hydrolysis of simvastatin in tablet were related to not only their hygroscopicity but also their other properties, such as moisture retention capacity and pH. Sorbitol as hygroscopic excipient in tablet can most effectively prevent the hydrolysis of simvastatin in tablet.
Studies on alkaline phosphatase. Phosphorylation of calf intestinal alkaline phosphatase by 32P-labelled pyrophosphate (1968)

1. A purified preparation of alkaline phosphatase from calf-intestinal mucosa was phosphorylated by (32)P-labelled PP(i) at a serine residue on the enzyme. Under the conditions employed, up to 0.15mum-labelled sites were obtained from 1mum-[(32)P]PP(i). 2. The phosphorylated enzyme was labile, the rate of dephosphorylation being similar to the overall rate of substrate hydrolysis. 3. A stopped-flow technique was used to determine the number of phosphomonoesterase active sites, which agreed with the number of (32)P-labelled sites. 4. It is concluded that calf-intestinal alkaline phosphatase is both a phosphomonoesterase and a pyrophosphatase.
Requirements for configuring Cryptographically Generated Addresses (CGA) and overview on RA and DHCPv6-based approaches (2008)

This document analyzes the requirements for the configuration
Cryptographically Generated Addresses and Multi-key CGAs. The
applicability of Router Advertisement and DHCPv6 for this
configuration is also discussed.
Coaxial-to-waveguide transition (end-launcher type) (1976)

A general formula for the design of an end-launcher type of transition from a coaxial line to rectangular, as well as a circular waveguide terminated in any arbitrary impedance, is developed. The application of the analysis to some important practical cases is illustrated.
Development of an advanced low energy focused ion beam system based on immersion optics (2006)

A new method of measuring polymorphonuclear leukocyte (PMN) microbicidal activity was developed in which single colony forming units of Staphylococcus aureus were isolated in microtiter wells with or without PMN, centrifuged, and incubated overnight. The percentage of bacteria killed was determined by comparing the number of PMN-containing wells showing bacterial growth to PMN-free controls. This percentage was positively correlated with the number of PMN in each well and was reduced if plates were not centrifuged or if cytochalasin B was added. Killing of either S. aureus or Escherichia coli was enhanced using fresh serum activated by prior exposure to large numbers of E. coli. There was no enhancement using heated serum that had been exposed to E. coli, nor was there enhancement when S. aureus was preopsonized by exposure to fresh serum. This assay circumvents problems in assessing microbicidal activity where aggregation of organisms might otherwise be an issue.
Inaugural Address—Session 1915-16 (1921)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Asynchronous transpose-matrix architectures (1997)

The matrix transposition operation is a necessary step in several image/video compression and decompression algorithms, in particular the discrete cosine transform (DCT) and its inverse (IDCT), and some distributed arithmetic applications. These algorithms have to be performed at high data-rates, and with a minimum of power dissipation for portable applications. The authors describe how the clocked solution is usually implemented, and present two new asynchronous architectures that perform matrix transposition. These architectures, one based on two phase signaling, one based on four phase signaling, have better characteristics than the clocked solution in terms of latency and power, at no cost in area or throughput. They discuss the characteristics of these three architectures and evaluate the relative advantages of each one.
Targeted advertising optimization using vector space model for online behavior on news portal computational advertising case study: Harianjogja.com (2013)

Targeted advertising is the placement of advertising in order to reach much attraction as many users. The raise of targeted advertising can be gain by using an optimization on demography, geography, and online behavior. While online advertising behavior is that gather information about the online activities of web users (such as visited web user) and use it to display relevant ads or content to the web user habits. Everyday, thousands of users online treated by many kinds of advertisement, but not all of them were eye-catching. This phenomenon is playing an important role related to the interest of web users who will click on the advertisement. The development of computational advertising in Indonesia grew fastly, especially in news portal online. However, there were still many problems such as the sameness display ads on all topic in some news topic and the irrelevance between the advertisement with the news topic (for example: the stationary advertisement on the sport news). Consequently, the advertisement can not attract the attention of web users because it does not fit with the habits and intentions of visitors. So, it is necessary to optimize the system of advertisement showing in order to attract more web users who will visit the advertisement. This research will focus on optimizing behavior targeted online advertising that aims at adjusting display ads with habits of web users.
Acerola and cashew apple as sources of antioxidants and dietary fibre (2010)

Summary Several tropical fruits have been described as natural sources of dietary fibre (DF) and phenolic compounds, associated with different health effects. The aim of this work was to ascertain the DF, phenolic compounds content (including non‐extractable polyphenols, mostly associated with DF) and antioxidant capacity in acerola fruits and cashew apples from selected clones. ‘BRS 236’ acerola fruits presented a high antioxidant capacity because of the combination of both extractable polyphenols and l ‐ascorbic acid (providing together a Folin value of 170 kg −1 g d.m.). ‘CCP 76’ cashew apples contained 28 g kg −1 d.m. of extractable polyphenols and 13 g kg −1 d.m. of ascorbic acid as well as a high amount of non‐extractable condensed tannins (52 g kg −1 d.m.). DF content was of 260 g kg −1 d.m. in acerola fruit and of 209 g kg −1 d.m. in cashew apple. Acerola fruits and cashew apple should therefore be considered as new natural sources of DF and phenolic compounds.
Propagation characteristics of surface acoustic waves in single-electron transport devices and the electrical measurement (2011)

We focused on investigating the propagation characteristics of surface acoustic waves (SAWs) in SAW-based single-electron-transport (SAW/SET) devices. SAW/SET devices operating in the gigahertz frequency range were fabricated on a GaAs/Al(x)Ga(1-x)As heterostructure. The transmittance and reflection performances of SAW/SET devices were obtained via the electrical measurement. Modeling based on coupling-of-modes theory was introduced to analyze SAW/ SET devices. Based on this model, many second-order effects such as propagation loss and the mechanical and electrical loadings caused by electrode perturbation of the surface were taken into account. Multiple-transit reflections of SAWs were also contained in the calculation. The calculated transmittance and reflection performances were in good agreement with the measured data. Furthermore, we proposed four interference types which could satisfactorily explain the periodic oscillations presented in the acoustoelectric current versus frequency characteristics.
Polymorphisms of platelet membrane glycoprotein Ib alpha and plasma von Willebrand factor antigen in coronary artery disease. (1999)

To examine the relationships of two polymorphisms of platelet glycoprotein (GP) Ib alpha and coronary artery diseases (CAD) in Japanese patients, we conducted a case-control study with 158 Japanese patients and 169 control subjects. The frequencies of HPA-2 polymorphism and the variable number of tandem repeat (VNTR) polymorphisms in the macroglycopeptide region did not significantly differ between CAD patients and control subjects. The polymorphisms of GPIb alpha were not associated with the number of affected vessels in CAD patients. When patients with acute coronary syndrome only were analyzed, the frequencies of the two polymorphisms of GPIb alpha showed no significant difference. Although plasma von Willebrand antigen (vWF:Ag) levels in patients were significantly higher than in controls, no association between vWF concentration and GPIb genotypes was observed. In patient groups with higher or lower vWF:Ag concentrations, no increase in the frequencies of Met145 or larger VNTR polymorphisms was seen in either group. Our findings indicate that no association exists between the frequencies of the two polymorphisms of GPIb alpha and CAD.
Titration of human serum antibodies to Toxoplasma gondii with a simple fluorometric assay (1978)

A new technique, FIAX, has been evaluated for the serodiagnosis of toxoplasmosis. It is based on a "dipstick" principle, and a special fluorometer is used to perform the indirect immunofluorescence test. The procedure appears to be simple and rapid and merits consideration as a useful serological test for toxoplasmosis.
Performance issues for the 88110 RISC microprocessor (2003)

The Motorola 88110 RISC (reduced instruction set computer) microprocessor is a second-generation, superscalar implementation of the 88000 architecture that is capable of achieving extremely high-performance for a broad class of general-purpose and scientific applications. In order to attain this performance, however, a balance is needed between hardware and software. With the development of optimizing compilers and accurate simulation tools for the 88110 it has been possible to begin tuning 88110 performance long before a system becomes available for software development and experimentation. The author describes the compilation and simulation environments developed for the 88110, and summarizes a number of key performance issues for the processor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Controlling Size in Multicellular Organs: Focus on the Leaf (2008)

In leaves, cells get larger as cell division decreases or the ploidy increases. This might seem a logical response, but the controls are more complicated.
A METABONOMICS STUDY OF COLORECTAL CANCER BY RRLC-QTOF/MS (2013)

Colorectal cancer (CRC) is a major cause of worldwide mortality and morbidity. To find effective metabolic biomarkers is valuable for early CRC detection, which plays a key role in patient survival rate. Urinary metabolic differences between CRC patients and healthy controls were investigated using rapid resolution liquid chromatography/quadrupole time-of-flight mass spectrometry (RRLC-QTOF/MS). Urine samples were studied in positive mode by ESI-MS and then the resulting data matrices were analyzed by multivariate statistical analysis. Urine samples of CRC patients were successfully distinguished from those of healthy controls. A total of ten significantly changed metabolites have been found and identified as potential biomarkers. This MS based method could not only provide a deep insight into mechanisms and identify novel cancer biomarkers, but also can lead to substantial decrease of analysis time and the increase of sensitivity and specificity. Our results suggest that CRC urinary metabolites might reflect specific tumor metabolisms and could be used as potential urinary metabolic biomarkers to reflect pathological changes of CRC.
The Journey Ahead – Transition from Brick and Mortar to Ecommerce: Gen Y Perspective (2015)

While few Customers prefer to make purchases online others don't. What decision-making factors affect their choice of purchase channel? In this paper, we share some of our observations in order to give a fair understanding for a new entrant in retailing to choose the best operating sales channel between Ecommerce and Brick & Mortar to achieve more sales. This study offers literature review to explain the concept of customers’ choice of channel selection for their purchases. We build the framework using statistical models deploying factor & discriminant analyses. The key findings from our study indicate that, certain factors differentiates between online and brick & mortar stores. It is however critical to understand the variables that best discriminate among the group which influences a consumer to make a purchase channel decision. The study will enable entrepreneurs to better understand and manage what really matters for customers.
Trifluoperazine Enhances Accumulation and Inhibits Phosphohydrolysis of Phosphatidate in Thrombin-Stimulated Platelets (1990)

Trifluoperazine (TFP) in concentrations up to 10-15 microM increased the formation of phosphatidic acid (PA) in platelets treated with 0.5 U/ml of thrombin, while higher concentrations of TFP inhibited formation of PA. Liberation of arachidonate (AA) from platelet phospholipids was progressively inhibited as the concentration of TFP increased. At thrombin doses lower than 0.1 U/ml TFP, (less than or equal to 25 microM) enhanced PA formation with either no effect of AA liberation (6 donors) or with much greater enhancement of PA formation than the decrease in liberation of AA (3 donors). The enhancement of PA formation by TFP did therefore not seem to be due to inhibition of phospholipase A2 (PLA2) by the phenothiazine, which has been suggested. We show further that TFP inhibits PA phosphohydrolase in platelet lysates, although with complex kinetics. It is therefore concluded that the enhancement of thrombin-induced PA production by TFP is not caused by inhibition of PLA2 but could be due to TFP-induced inhibition of PA phosphohydrolase.
Gel permeation chromatography of heated fats (1973)

Abstract The high and low molecular weight components of heated fats have been separated with gel permeation chromatography. With Sephadex LH‐20, as well as with Biobeads SX‐1, the high molecular weight components of heated fats may be directly separated when chloroform, acetone, chloroform‐methanol or tetrahydrofuran are employed as swelling agents and eluting solvents.
Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons (2011)

We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in Parkinson's disease (PD). The implication of neuroinflammation on this disease was originally established in 1988, when the presence of activated microglia in the substantia nigra (SN) of parkinsonians was reported by McGeer et al. Neuroinflammation could be involved in the progression of the disease or even has more direct implications. We injected 2 μg of the potent proinflammatory compound lipopolysaccharide (LPS) in different areas of the CNS, finding that SN displayed the highest inflammatory response and that dopaminergic (body) neurons showed a special and specific sensitivity to this process with the induction of selective dopaminergic degeneration. Neurodegeneration is induced by inflammation since it is prevented by anti-inflammatory compounds. The special sensitivity of dopaminergic neurons seems to be related to the endogenous dopaminergic content, since it is overcome by dopamine depletion. Compounds that activate microglia or induce inflammation have similar effects to LPS. This model suggest that inflammation is an important component of the degeneration of the nigrostriatal dopaminergic system, probably also in PD. Anti-inflammatory treatments could be useful to prevent or slow down the rate of dopaminergic degeneration in this disease.
Comparison of 1α-OH-Vitamin D<sub>3</sub> and High Doses of Calcium Carbonate for the Control of Hyperparathyroidism and Hyperaluminemia in Patients on Maintenance Dialysis (1985)

27 patients on hemodialysis (dialysate aluminium less than 0.7 mumol/l for 2 years, and 2 mumol/l before) whose plasma Ca and PO4 were adequately controlled for already 6 months by high doses of CaCO3 alone (mean +/- SD: 9 +/- 5 g/day), were randomly divided into 2 groups, a control group (c group) which was kept on the same treatment, and a group in which CaCO3 was reduced to 3 g/day but in which plasma Ca was kept normal due to 1 alpha-OH-vitamin D3 administration (1 microgram/day at the beginning, 0.3 microgram/day after 6 months; 1 alpha group) whereas plasma phosphate was kept below 6.0 mg/dl because of Al(OH)3 (2.7-5 g/day). Initially, the 2 groups were comparable as regards the plasma concentrations of total and ionized Ca, phosphate, alkaline phosphatases, medium and C-terminal parathyroid hormone (PTH) and aluminium, but the control group had lower plasma 25-OH-vitamin D (25-OHD.) After 6 months, the same difference in plasma 25-OHD was found with comparable plasma concentrations of total and ionized calcium as well as of medium and C-terminal PTH (beta error 1%). However, plasma concentration of phosphate and the plasma Ca phosphate product, as well as the plasma aluminium were higher in the 1 alpha group whereas their PCO3H- was lower. Although the alkaline phosphatase values were not significantly different between the 2 groups, they increased only in the control group because of 1 patient who developed a vitamin-D-deficient osteomalacia (plasma 25-OHD 3 ng/ml), which was subsequently cured by physiological doses of 25-OHD3. The incidence of transient hypercalcemia (15 vs. 21 episodes) and worsening of soft tissue calcifications (3 in each group) was the same in the 2 groups.
Carbon black : production, properties, and uses (2011)

Preface Carbon Blacks in Electrochemical Energy Conversion Devices: Uses & Applications in Fuel Cells Study & Application of Carbon Black Vulcan XC-72R in Polymeric Electrolyte Fuel Cells Intermolecular & Intramolecular Interaction at Adsorption on the Surface of Graphitized Thermal Carbon Black Heat Transfer & Growth of Primary Black Carbon Particles in Gas Mixture What Does Carbon Nanomaterial Cause in Human Health? Carbon Black Low Pressure Plasma Processing of Carbon Black: A New Class of Granular Adsorbers of Acid and/or Basic Compounds Production, Properties & Applications of Carbon Blacks in Rechargeable Lithium-Ion Batteries A Review of Current Analytical Applications Employing Graphitized Carbon Black Effect of Carbon Black Fillers on the Tribological Properties of PTFE The Application of Carbon Black in Energy Storage Index.
Thickness and Refractive Index Measurement of a Lamina with a Michelson Interferometer* (1966)

A description is given of a modification of Foch’s method for precise measurement of the thickness and the refractive index of a lamina. White-light reflection fringes from the lamina are compared in a spectrometer with the fringes produced by a Michelson interferometer when one light path in the interferometer contains the lamina. Analysis and experiment show that the interferometer fringes may be brought into perfect register with the reflection fringes over the entire spectrum regardless of the dispersion of the lamina.
Suppressive role of the metastasis-related nm23-H1 gene in human ovarian carcinomas: association of high messenger RNA expression with lack of lymph node metastasis. (1995)

The nm23-H1 gene has been proposed as a metastasis suppressor gene. It is located on the long arm of chromosome 17, which is frequently deleted in ovarian cancer, and shows altered expression and structure in some advanced neoplasms. To evaluate the role of nm23-H1 in ovarian carcinogenesis, we have analyzed this gene in 66 primary human ovarian carcinomas at both the DNA and RNA levels. Despite the high frequency (76%) of nm23-H1 loss of heterozygosity (LOH), the complete absence of gene mutations in the coding portions of the retained allele clearly indicated that, in ovarian carcinomas, this gene does not function in the same way as do classic oncosuppressor genes. The relationship of clinicopathological parameters with nm23-H1 gene deletions and expression levels was also investigated. LOHs were more common in the serous and endometrioid histotypes (85 and 93%, respectively), and the highest LOH frequency was detected in poorly differentiated tumors (89%). A significant relationship between nm23-H1 mRNA expression and lymph node metastasis was observed in high-grade tumors, which are intrinsically more invasive than are low-grade tumors. In particular, among the poorly differentiated tumors showing areas of undifferentiated solid carcinoma (classified as G3/G4), lymph node-negative tumors displayed expression levels that were significantly higher than those of lymph node-positive tumors (P < 0.001). In conclusion, our data suggest that the nm23-H1 gene product may exert an inhibitory effect on the lymphatic dissemination of human ovarian tumors. However, several other factors, biological or time and patient dependent, influence the complex metastatic progression of ovarian tumors and may cooperate with nm23-H1 in the promotion or inhibition of this process.
Measurement of Electrical Conductivity of Glass Melter at High Temperature (2000)

The electrical conductivity of glass melter at high temperature has been measured. The conductivity is an important physical property for the research and the manufacturing process of glass. Because high temperature is an inconvenient situation to measure the conductivity of glass melter, we have made a platinum crucible and electrode and have measured the conductivity at high temperature. KCl solution, of which concentration is adjusted to the conductivity of glass melter, is used to get parameters of the conductivity cell. A measuring circuit is composed with an AC 1 kHz sine wave generator and an operational amplifier. The cell constants are determined from the measured voltages and the equivalent conductances of KCl solution. Various cells are tested to find a suitable shape for high temperature experiment. The results are compared by cell size, electrode depth, and cell configuration. The conductivity of the borosilicate melter is at .