gebhart/patrepeval huggingface dataset:
New synthesis of azabufalin from C-17 steroidal ketones (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew synthesis of azabufalin from C-17 steroidal ketonesMin Jen ShiaoCite this: J. Org. Chem. 1982, 47, 26, 5189–5191Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/jo00147a030https://doi.org/10.1021/jo00147a030research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Essential Helicase Gene <i>RAD3</i> Suppresses Short-Sequence Recombination in <i>Saccharomyces cerevisiae</i> (1995)

We have isolated an allele of the essential DNA repair and transcription gene RAD3 that relaxes the restriction against recombination between short DNA sequences in Saccharomyces cerevisiae. Double-strand break repair and gene replacement events requiring recombination between short identical or mismatched sequences were stimulated in the rad3-G595R mutant cells. We also observed an increase in the physical stability of double-strand breaks in the rad3-G595R mutant cells. These results suggest that the RAD3 gene suppresses recombination involving short homologous sequences by promoting the degradation of the ends of broken DNA molecules.
Fraction from human and rat liver which is inhibitory for proliferation of liver cells. (1989)

A comparative study was undertaken with human and rat liver of a fraction reported to have growth inhibitory activity when prepared from rat liver. Fractions which were soluble in 70% ethanol and insoluble in 87% ethanol were prepared from liver cytosols. Electrophoretic analysis under denaturing conditions indicated that there were several quantitative or qualitative differences in the fractions from the two species. Fractions from both human and rat liver were found to be inhibitory for the incorporation of 3H-thymidine into DNA of foetal chick hepatocytes. Under conditions in which the rat fraction inhibited precursor incorporation into DNA of rat liver epithelial cells there was not a significant inhibitory effect with the fraction from human liver. DNA synthesis in a rat hepatoma cell line was not significantly inhibited by preparations from either species. The data suggested that corresponding fractions from both rat and human liver could have inhibitory effects on precursor incorporation into DNA but the magnitude of the effects and target cell specificity may differ.
Isolation and culture of pulmonary endothelial cells. (1984)

Methods for isolation, identification and culture of pulmonary endothelial cells are now routine. In the past, methods of isolation have used proteolytic enzymes to detach cells; thereafter, traditional methods for cell passaging have used trypsin/EDTA mixtures. Cells isolated and passaged using proteolytic enzymes have been useful in establishing the field and in verifying certain endothelial properties. However, there is a growing awareness of the role of endothelial cells in processing vasoactive substances, in responding to hormones and other agonists and in cell-cell interactions with other cell types of the vascular wall, with blood cells and with cellular products. Consequently, a new requirement has arisen for cells in vitro that maintain the differentiated properties of their counterparts in vivo. The deleterious effects of trypsin and other proteolytic enzymes commonly used in cell culture on surface structures of endothelial cells such as enzymes, receptors and junctional proteins, as well as on extracellular layers such as the glycocalyx or "endothelial fuzz," have led to the development of methods that avoid use of proteolytic enzymes at both the isolation step and during subsequent subculture. This chapter describes traditional methods for isolating pulmonary endothelial cells but emphasizes newer approaches using mechanical harvest and scale-up using microcarriers. The new methods allow maintenance of long-term, large-scale cultures of cells that retain the full complement of surface properties and that maintain the cobblestone monolayer morphology and differentiated functional properties. Methods for identification of isolated cells are therefore also considered as methods for validation of cultures during their in vitro lifespan.
Resurgence of Cardiac T-Tubule Research (2007)

The transverse tubules of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent data have revealed that their structure and function are more complex than previously believed. Here, we review current knowledge about their role in cardiac function, focusing on Ca2+ signaling and changes observed in pathological conditions.
Simple IP subnet VLAN implementation (2005)

This paper describes a simple method of implementing an IP subnet VLAN. Normally, switches have to exchange VLAN membership information with its neighboring switches via some form of VLAN registration protocol. This is to ensure proper operation of VLAN forwarding and VLAN filtering services in a LAN. However, in the implementation done by the authors in this paper, no VLAN membership information is exchanged between any switches. The VLAN registration protocol is simply replaced by the router that sends a simple periodic multicast packet to all switches in the LAN. Some conformance testing is done to verify the correctness of the implementation. Some minor limitations about the implementation are described as well.
Microlensing Searches for Extrasolar Planets (2002)

I review results from, and future prospects for, microlensing searches for extrasolar planets. Analyses of well-sampled microlensing light curves by several collaborations have demonstrated that current searches are sensitive to Jupiter-mass planets with few AU separations from M-dwarfs in the Galactic bulge. To date, however, no unambiguous planetary detections have been made. Detailed analysis has shown that this null result implies that <33% of typical stars (i.e. M-dwarfs) in the Galactic bulge have Jupiter-mass companions with separations between 1.5 and 4 AU, and <45% have three-Jupiter-mass companions between 1 and 7 AU. The recent dramatic increase in the number of alerts per year will allow ongoing microlensing searches to probe companion fractions of a few percent within a few years. I conclude by speculating on the prospects for the detection of terrestrial-mass and free-floating planets from the ground and space.
Serial Polyandry and Alloparenting in Long-Eared Owls (2002)

Abstract We used DNA fingerprinting to document serial polyandry in a double-brooded female Long-eared Owl (Asio otus) in western Montana. We also determined that an extra male that helped provision offspring at a nest was a close relative of the female parent. The nest had split paternity, and it is not clear whether the helper was the sire or brother of two of the four nestlings. These data constitute the first known cases of serial polyandry and alloparenting in Long-eared Owls and leave open the question of whether cooperative polyandry also occurs in this species. Poliandría en Serie y Alopaternidad en Asio otus Resumen. Empleamos huellas dactilares genéticas (i.e., DNA fingerprinting) para documentar poliandría en serie en una hembra de Asio otus que presentó dos nidadas, en el oeste de Montana. También determinamos que un macho extra-pareja que ayudó a abastecer a los pichones en un nido era un pariente cercano de la madre. El nido presentó paternidad compartida y no está claro si el ave que ayudaba era el padre o el hermano de dos de los cuatro polluelos. Estos datos representan el primer caso conocido de poliandría en serie y alopaternidad en Asio otus, y deja abierta la pregunta si en esta especie también ocurre poliandría cooperativa.
Caring for Children and Adults: Differential Access to Family-friendly Work (2005)

The importance of parents having access to work arrangements that enable them to adequately care for their children is widely recognised and accepted. Much less attention has been given to the importance of creating work places that allow employees to provide care for elderly, disabled, or ill parents, spouses or other adults. As the population ages over the next few decades, increasing numbers of employees will be providing care for their parents or other adults. This paper presents evidence on the use of flexible work arrangements to provide adult care and how this compares to the use by those caring for children
High Modulus, Strength, and Toughness Polyurethane Elastomer Based on Unmodified Lignin (2017)

Lignin-based polyurethane elastomers (LPUe) with high stiffness, strength, and toughness were facilely prepared by direct cross-linking of unfunctionized lignin as hard segments and poly(propylene glycol) tolylene 2,4-diisocyanate terminated (PPGTDI) as soft domains. The effects of lignin molecular weight (3600 and 600 g mol–1) and weight fraction (5–40 wt %) on the thermal and mechanical properties of LPUe were studied. With an increase in lignin content, LPUe exhibited improved thermal stability, and the glass transition temperature (Tg) also increased, especially for LPUe derived from lignin with low lignin molecular weight of 600 g mol–1 (600-LPUe). Furthermore, LPUe also exhibits excellent mechanical properties. For 600-LPUe with 40 wt % of lignin, the Young’s modulus, tensile strength, and strain at break reach 176.4 MPa, 33.0 MPa, and 1394%, respectively, which could be attributed to better dispersion of low molecular weight lignin in elastomers as evident from DSC, SEM, and TEM studies. Our results demonstrate the potential application of unmodified lignin in developing biobased high-performance PU materials. This is in contrast to many current studies of LPUe systems that need lignin modification to prepare PU materials.
Surmounting Health Information Network Barriers: The Greater Dayton Area Experience (1998)

The greater Dayton area has begun building the nation's first advanced technology community network for sharing patient medical information among independent hospitals. Its success in doing so has resulted from the surmounting of numerous business and technical barriers. Others planning to develop such networks can learn from the Dayton experience.
Miya Hook ligature carrier for sacrospinous ligament suspension. (1987)

The Miya Hook ligature carrier makes sacrospinous ligament suspension of the prolapsed vagina or uterus easier and safer. Seventy-four procedures were performed in a 24-month period, chiefly by residents in training. There were no hemorrhages or injuries to nerve or rectum. The coccygeus muscle and sacrospinous ligament are one and the same fibromuscular structure.
Ferroelectricity, Domain Structure, and Phase Transitions of Barium Titanate (1950)

A summarizing account is given of the research on barium titanate in progress at the Laboratory for Insulation Research at M. I. T. since 1943. The investigations have led to an understanding of the mechanism of ferroelectricity in the titanates and to discoveries such as the piezoelectric effect in the ceramics and the domain structure of the single crystals of BaTi${\mathrm{O}}_{3}$. The high dielectric constant, field strength and temperature sensitivity, and piezo-response of the barium titanate dielectrics make them useful for numerous technical applications.
Multilocus Sequence Typing Scheme for Bacteria of the <i>Bacillus cereus</i> Group (2004)

In this study we developed a multilocus sequence typing (MLST) scheme for bacteria of the Bacillus cereus group. This group, which includes the species B. cereus, B. thuringiensis, B. weihenstephanensis, and B. anthracis, is known to be genetically very diverse. It is also very important because it comprises pathogenic organisms as well as bacteria with industrial applications. The MLST system was established by using 77 strains having various origins, including humans, animals, food, and soil. A total of 67 of these strains had been analyzed previously by multilocus enzyme electrophoresis, and they were selected to represent the genetic diversity of this group of bacteria. Primers were designed for conserved regions of housekeeping genes, and 330- to 504-bp internal fragments of seven such genes, adk, ccpA, ftsA, glpT, pyrE, recF, and sucC, were sequenced for all strains. The number of alleles at individual loci ranged from 25 to 40, and a total of 53 allelic profiles or sequence types (STs) were distinguished. Analysis of the sequence data showed that the population structure of the B. cereus group is weakly clonal. In particular, all five B. anthracis isolates analyzed had the same ST. The MLST scheme which we developed has a high level of resolution and should be an excellent tool for studying the population structure and epidemiology of the B. cereus group.
Grace cups (1856)

Journal Article Grace cups Get access Grace cups H. L. K. Grace cups H. L. K. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s2-II, Issue 28, 12 July 1856, Page 31, https://doi.org/10.1093/nq/s2-II.28.31a Published: 12 July 1856
Properties of Cu film under XeCl excimer laser irradiation (1992)

Sputter deposited Cu films on top of a substrate were melted and recrystallized by irradiating under a XeCl (308 nm) excimer laser with a 45 ns pulse duration at substrate temperatures of 20, 365, and 440 °C. The properties of the irradiated film, such as sheet resistance, reflectance, grain size, stress, and preferred orientation were characterized as a function of the laser fluence at each of temperatures. The results show a decrease in sheet resistance and specular reflectance, and an increase in grain size after laser irradiation. The net stress of the film stack changes from compressive to tensile with substrate heating and laser irradiation and the polycrystalline orientation of the Cu films changes from (111) for the as-deposited sample to (110) after laser irradiation. The significance of these results is discussed.
A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease (2015)

Alcoholic liver disease (ALD) is a major health problem worldwide, and alcohol is well-known to cause mitochondrial damage, which exacerbates alcohol-induced liver injury and steatosis. No successful treatments are currently available for treating ALD. Therefore, a better understanding of mechanisms involved in regulation of mitochondrial homeostasis in the liver and how these mechanisms may protect against alcohol-induced liver disease is needed for future development of better therapeutic options for ALD. Mitophagy is a key mechanism for maintaining mitochondrial homeostasis by removing damaged mitochondria, and mitophagy protects against alcohol-induced liver injury. Parkin, an E3 ubiquitin ligase, is well-known to induce mitophagy in in vitro models although Parkin-independent mechanisms for mitophagy induction also exist. In this review, we discuss the roles of Parkin and mitophagy in protection against alcohol-induced liver injury and steatosis. We also discuss Parkin-independent mechanisms for mitophagy induction, which have not yet been evaluated in the liver but may also potentially have a protective role against ALD. In addition to mitophagy, mitochondrial spheroid formation may also provide a novel mechanism of protection against ALD, but the role of mitochondrial spheroids in protection against ALD progression needs to be further explored. Targeting removal of damaged mitochondria by mitophagy or inducing formation of mitochondrial spheroids may be promising therapeutic options for treatment of ALD.
[Effects of sapindoside on blood pressure and vasoactive substance in renovascular hypertension rat]. (2007)

Sapindoside plays an important role in decreasing the blood pressure of renovascular hypertension rat.
An adaptive intrusion detection system using neural networks (1998)

As the Internet expands both in number of hosts connected and in terms of the number of services provided, security has become a key issue for the technology developers. This work presents and analyses a prototype of an intrusion detection system. This system, positioned at key points of the network, will keep looking at the passing packets, in search of suspicious connections. The system provides a list of such connections for the administrator, enabling him/her to take the proper action at an early stage of the intrusion. Neural Networks are used to look for profiles of intrusion within the analysed data streams. The assessment is done through comparison with well-known profiles of intrusion. The system is highly adaptive, since new profiles can be added to the database and the Neural Network re-trained to consider them.
SHORT NOTICES (1993)

Journal Article SHORT NOTICES Get access Biblia Patristica. Index des citations et allusions bibliques dans la littérature patristique. Volume 5. Basile de Cesaree , Grégoire de Nazianze, Grégoire de Nysse, Amphiloque d'Iconium. Pp. 409. Paris: Éditions du Centre National de la Recherche Scientifique, 1991. ISBN 2 222 04591 6. N. p. MAURICE WILES MAURICE WILES Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume 44, Issue 1, April 1993, Pages 491-b–491, https://doi.org/10.1093/jts/44.1.491-b Published: 01 April 1993
Radiation Response of Mouse Lymphoid and Myeloid Cell Lines. Part III. Different Signals Can Lead to Apoptosis and May Influence Sensitivity to Killing by DNA Double-strand Breakage (1994)

We have examined the timing of gamma-irradiation-induced death in relation to cell cycle progression using a panel of mouse lymphoid or myeloid cell lines. Death was found to occur immediately after irradiation ('rapid interphase' death), or after arrest in G2 phase ('delayed interphase' death). In part II of this series of papers we demonstrated the occurrence of radiation-induced apoptosis in all these cell lines. This suggests that different signals can lead to apoptosis in these cell lines. DNA double-strand breakage appeared to directly stimulate the destruction of cell lines susceptible to rapid interphase death, whilst the signal for delayed interphase and mitotic death, whilst the signal for delayed interphase and mitotic death appeared to be chromosomal aberrations. Several of the cell lines showed different timing of death dependent upon the radiation dose used. These differences in the timing of radiation-induced death are shown to be useful indicators of the relative radiosensitivity of haematopoietic cell lines.
Characterization of Gallium-induced Intergranular Fracture Surface and the Auger Electron Spectroscopic Analysis for Mg Grain Boundary Segregation in AA6061 T4 Al-Mg-Si Alloy (2004)

This investigation examines the grain boundary segregation of Mg and Si in AA6061-T4 alloy, using Auger electron spectroscopy technology. Liquid metal embrittlement by gallium was conducted to fracture the AA6061-T4 alloy intergranularly to obtain compositional information directly from the grain boundary facets. The amount of liquid gallium applied is controlled to break the alloy intergranularly at room temperature, importantly without Ga-bearing particles or a film covering the fracture surface. The method of generating a fully intergranular fracture surface for AA6061 is elucidated. The AES analysis reveals that Mg in 6061 T4 alloy is segregated at grain boundaries, but Si does not. The segregation of Mg depends on the rolling direction. The mean peak-to-peak ratio IMg/IAl of the specimen whose longitudinal axis is perpendicular to the rolling direction is about three times that of the specimen whose axis parallel thereto. The grain boundary segregation is not result oxidation-induced; surface segregation also makes no contribution.
Gold-Catalyzed Tandem Cyclizations of 1,6-Diynes Triggered by Internal N- and O-Nucleophiles (2010)

Investigations on gold-catalyzed tandem cyclization reactions of 1,6-diynes, tethered to nucleophilic functionalities such as amine, carboxylic acid, amide, and sulfonamide, are reported. The ability of such substrates to undergo tandem cyclization, triggered by internal nucleophiles, has been examined. Depending on the substrate, the catalytic system, and reaction conditions, different regioisomers of monocyclic and bridged bicyclic products were obtained.
CLINICAL ASPECTS OF PREGNANCIES ESTABLISHED WITH CLEAVING EMBRYOS GROWN <i>IN VITRO</i>* (1980)

Details are given of four pregnancies established by fetilization in vitro and planting cleaving embryos into the mother. The pregnancies were monitored by hormone assays in early pregnancy and by ultrasound scans. Amniocentesis was used to assess the levels of alpha-fetoprotein and the karyotype of the fetuses at 15 weeks. Placental function tests and X-rays were used to monitor late pregnancy in one patient. Three of the pregnancies began uneventfully and the fetuses were normal in all respects. Two were delivered at or near term, the third being aborted spontaneously at 21 weeks while the parents were on holiday. The fourth pregnancy did not develop normally and a triploid fetus was aborted 12 weeks after the last menstrual period. The clinical difficulties inherent in selecting patients and preparing them for treatment are described. Some possible improvements in techniques are also described.
Self-aligned cobalt disilicide/silicon Schottky barrier contacts: fabrication, materials and electrical characterization (1996)

Polycrystalline cobalt disilicide films have been formed successfully on n-type (100)- and (111)-oriented silicon substrates using a relatively low technology route involving cobalt metal evaporation and a rapid thermal annealing procedure. The same procedure has been used to fabricate Schottky barrier contacts using a self-aligned silicide process. The properties of the reacted overlayers and interfaces have been examined using nuclear reaction analysis, Rutherford backscattering spectrometry, cross-sectional transmission electron microscopy, sheet resistance, I - V and C - V measurements. Examination of the contacts using optical microscopy revealed lateral silicide overgrowth which has been explained by consideration of the known growth kinetics. These results lead to explanations for non-idealities in the electrical characteristics which show ideality factors as low as 1.03 and barrier heights typically of 0.65 eV.
Preparation and Properties of Poly(ether imide) Ultrafiltration Membrane Modified with Polyether Diamine (2014)

In this study, the morphologies, the hydrophilicity, and the anti-fouling of poly (ether imide) (PEI) membrane modified with an aqueous solution of polyether diamine predominantly PEO backbone (PEO-diamine) were investigated. A decrease in water contact angle and an increase in water absorption ratio indicated the hydrophilicity of modified membrane. Scanning Electron Microscope (SEM) showed a thinner skin layer of membrane and pores on the membrane surface for modified PEI membrane providing an increment of pure water flux and a reduction of BSA rejection of membrane. Under the protein filtration study, it was found that the flux recovery ratio of modified PEI membrane was higher than that of the unmodified PEI membrane.