gebhart/patrepeval huggingface dataset:
Investigation of crack propagation in X38CrMoV5 (AISI H11) tool steel at elevated temperatures (2010)

A method is developed to evaluate the surface fatigue damage of hot forming tools (forging, HPDC) that undergo thermo mechanical loading and environmental attack. Crack propagation under fatigue loading in a hot work tool steel X38CrMoV547HRC is investigated using SENT (single edge notched tension) specimens of 2.5∗8mm∗mm section. The effect of different testing conditions has been investigated: effect of thickness (ranging from 2.5mm–0.10mm), effect of R value and effect of temperature are observed on crack propagation properties of the steel. Paris curves are established. Numerical simulation is performed by ABAQUS® Standard to evaluate J integral and stress intensity factor KI. A new crack driving force parameter is introduced. Mechanisms of crack propagation have been studied under different test conditions.
Low-Energy Secondary Electron Filtering with Immersion Lens SEM (2009)

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009
Reductive Dimerization of Dithianylium Salts and Fluorodesulfuration: A New Synthetic Approach to Tetrafluoroethylene Substructures. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Ligand-induced endocytosis of the pattern recognition receptor FLS2 in <i>Arabidopsis</i> (2006)

Pattern-recognition receptors (PRRs) trigger innate immune responses in animals and plants. One such PRR is the flagellin receptor FLS2 in Arabidopsis. Here, we demonstrate that a functional fusion of FLS2 to the green fluorescent protein (GFP) resides in cell membranes of most tissues. Stimulation with the flagellin epitope flg22 induces its transfer into intracellular mobile vesicles, followed by degradation. FLS2 internalization depends on cytoskeleton and proteasome functions, and receptor activation. A variant FLS2 mutated in Thr 867, a potential phosphorylation site, binds flg22 normally, but is impaired in flg22 responses and FLS2 endocytosis. We propose that plant cells regulate pathogen-associated molecular pattern (PAMP)-mediated PRR activities by subcellular compartmentalization.
Opportunities for Protein Delivery by Aerosol (1991)

Inhalation offers some exciting possibilities for the delivery of new generation products of biotechnology like polypeptides and proteins. This article reviews some of the possibilities and describes a series of experiments in which the pulmonary absorption of a peptidase-resistant, synthetic polypeptide, poly-α,β-[N(2-hydroxyethyl)-D,L-aspartamide], containing a covalently bound fluorophore (F-PHEA), was studied in the isolated rat lung. Effects of administered dose and polydisperse molecular weight distribution (MWD) are described as they affect the amount of F-PHEA absorbed and its MWD following transfer to the pulmonary vasculature. Relatively small molecules, less than 5 kilo Daltons (kD) weight averaged molecular weight, appeared to be absorbed in similar MWDs to the administered material. Larger MWDs showed size selectivity in the absorption process. In these cases, the MWDs of absorbed material were consistently smaller than those of the administered polymers; at longer sample times as absorption proceeded, the % of larger molecules transferred to the vasculature also increased. Because mucociliary clearance from the lower airways is slow, substantial absorption of quite large molecules may be possible over 10-12 h periods following aerosol inhalation.
Characteristic Boundary Conditions for ARO-1 (1983)

Abstract : Characteristic boundary condition relations are derived in generalized coordinates for application to the unsteady Euler equations. Procedures are given for inclusion of these boundary condition routines in the computer program designated ARO-1.
THE EFFECT IN HUMANS OF EXTRACELLULAR pH CHANGE ON THE RELATIONSHIP BETWEEN SERUM POTASSIUM CONCENTRATION AND INTRACELLULAR POTASSIUM 1 (1956)

For many years investigators have been aware of the association of hyperkalemia with acidosis and hypokalemia with alkalosis.The early in vitro work of Fenn and Cobb (1) suggested that there might be a cause and effect relationship.However, it was not until recently that satisfac- tory in vivo data were obtained (2-7) which per- mitted the formulation of the hypothesis that changes in extracellular pH altered the extracel- lular potassium concentration independently of changes in total body potassium 3 (7).Thus, in animals, acidosis increases and alkalosis decreases the serum potassium concentration independently of changes in total body potassium.The present study demonstrates similar interrelationships in humans. EXPERIMENTAL PLAN AND METHODSFive patients were selected for study because of al- terations of extracellular pH of either metabolic or re- spiratory origin.During the nine periods of study (five in the same patient) an attempt was made to change ex- tracellular pH rapidly and observe the effect of this change on the serum potassium concentration.Extra- cellular pH was changed by appropriate therapy which included infusions of isotonic mixtures of NaCl, HCl, NH4C1, NaHCO, and sodium lactate.In one patient eight per cent CO2 inhalation was used in combination with HCl infusion.In order to control the effect of changes in total body potassium on the serum potassium concentration experimental periods were short and an at- tempt was made to change potassium balance only slightly
Synthesis and Cytotoxic Action of 1-Oxoalkyl and 1,2-Dioxoalkyl-1,2,4-triazolidine-3,5-diones in Murine and Human Tissue Cultured Cells (1999)

1-Oxoalkyl and 1,2-dioxoalkyl-1,2,4-triazolidine-3,5-diones proved to be potent antineoplastic agents in mouse tumors and potent cytotoxic agents particularly against the growth of suspended tumor cells. The compounds with shorter substituents in position 1 or positions 1 and 2 afforded the better activity. In L1210 lymphoid leukemia cells DNA, RNA, and protein syntheses were inhibited at 100 μM after 60 min. Multiple enzyme sites in nucleic acid metabolism were affected by the compounds, i.e. DNA polymerase α, PRPP-amido transferase, dihydrofolate reductase, thymidylate synthetase, and nucleoside kinases. These effects of the agents are probably additive in bringing about inhibition of DNA synthesis and cell death.
Processeur spécialisé pour le calcul de sons en temps réel par simulation instrumentale (1983)

International audience
Mathematical models of HIV pathogenesis and treatment (2002)

We review mathematical models of HIV dynamics, disease progression, and therapy. We start by introducing a basic model of virus infection and demonstrate how it was used to study HIV dynamics and to measure crucial parameters that lead to a new understanding of the disease process. We discuss the diversity threshold model as an example of the general principle that virus evolution can drive disease progression and the destruction of the immune system. Finally, we show how mathematical models can be used to understand correlates of long-term immunological control of HIV, and to design therapy regimes that convert a progressing patient into a state of long-term non-progression.
POLYPROPYLENE: AN INTRODUCTION (1999)

Polypropylene now has a history of nearly 45 years since its discovery and 40 years since its commercialization. It has established itself as one of the most important polymers that has engineering plastic properties at commodity plastics prices. The end of the growth of polypropylene is not in sight.
Heterogeneity of Deformation in Pure Ni Single Crystal of Cube Orientation Deformed by Equal Channel Angular Extrusion (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Case 9-1971 (1971)

Presentation of CaseA two-year-old girl was admitted to the hospital because of abdominal pain.The child had been in good health until three days before admission, when she complained of abdominal pain and vomited once. On the following day she vomited three times and continued to complain of pain. The frequency of urination did not change; she passed no stool. A cathartic was administered, and on the following day a hard stool of normal color was passed. The patient took small feedings without vomiting but continued to experience abdominal pain. On the day of admission the abdominal pain became . . .
Nonphosphatide Fatty Acyl Esters of Alkenyl and Alkyl Ethers of Glycerol (1963)

Evidence has been presented, in a preliminary communication from this laboratory (I), and by Schogt, Begemann, and Koster (2), to substantiate the previously postulated existence (3, 4) of nonphosphatide plasmalogens. This evidence was based mainly on observations made with unsaponifiable fractions obtained after treatment of neutral lipid with alkali. In our preliminary communication (I), for example, the neutral lipid of the digestive gland of the starfish (Asterius forbesi) was saponified. Fatty aldehyde was found to be released from the unsaponifiable fraction by mild acid treatment, and was detected with fuchsin. The color reaction used by Norton (5) to detect a&vinyl ethers’ of the phosphatide series (phosphatide plasmalogens) * Supported by grants from the American Heart Association and the Massachusetts Heart Association. 1 Since the discovery of the nature of the aldehydogenic linkage in the plasmalogens (6,7), these compounds have been referred to by many authors as &vinyl ethers of glycerol. This terminology could conceivably cause confusion in that the carbon atoms of the glycerol moiety are often referred to as LY, 8, and (Y’ in assignments of positions of attachment of various entities to the glycerol backbone.
Ionic liquid-based variable focus electrowetting optics with bandwidths\n spanning the visible to mid-infrared (2016)

Infrared optical materials and devices are important for a wide range of\napplications in the defense, scientific, and consumer markets. For imaging,\nspectroscopy, microscopy and persistent surveillance, adaptive optic systems\nthat span the visible to infrared region are particularly useful. We address\nthis need with novel electrowetting lens and prism elements that operate from\n400 to 5000 nm. In contrast to conventional electrowetting devices that use\npolar liquids, limited by high absorption in the infrared region, we present\nroom-temperature ionic liquid-based (RTIL, N-Propyl-Nmethylpyrrolidinium\nBis(fluorosulfonyl)imide, Pyr1333a, Solvionic) lens and prism elements with\nunprecedented spectral bandwidths. Our electrowetting lenses tune over 20\ndiopters and have been demonstrated at 588, 1550 and 3000 nm wavelengths.\nAdditionally, we have demonstrated prism elements with a steering angle of\n0.56{\\deg} at 1550 nm.\n
Use of FDG-PET for early response assessment of novel EGFR kinase inhibitors in mouse models of lung cancer (2010)

506 Objectives The recent discovery of novel mutant-selective EGFR kinase inhibitors (ref. 1) may accelerate the progress in finding effective therapies against EGFR-driven non-small-cell lung cancer (NSCLC) in which resistance to conventional EGFR inhibitors develops through acquisition of the T790M gatekeeper mutation. Our goal was to evaluate the usefulness of FDG-PET in monitoring the treatment response of these novel kinase inhibitors in vivo using genetically-defined mouse lung cancer models. Methods Lung tumors were induced in mice through the conditional activation of a transgenic EGFR allele carrying both a deletion of exon 19 (activating mutation) and a T790M gatekeeper mutation. Baseline FDG-PET scans were performed when mice developed respiratory symptoms. Mice were assigned to treatment with either vehicle or the irreversible EGFR inhibitor WZ4002. After 3 days of treatment, post-treatment imaging was performed and the tumor SUVs in the lungs were compared between baseline and post-treatment scans. Each mouse as fasted overnight before imaging, administered with ~400 uCi 18F-FDG (~0.2cc) through intraperitoneal injection, warmed and awake during a 60 min. tracer uptake period, and then anesthetized before undergoing 10 min. PET scan. Results The baseline FDG-PET scans were able to consistently identify high tumor glucose utilization in the mouse lung cancer models (SUVmax: ~2.0 or higher). After 3 days of treatment, the SUVmax in the lungs of those mice treated with WZ4002 had dropped to background levels ( Conclusions FDG-PET can be used to monitor the treatment response of novel EGFR kinase inhibitors in vivo using mouse lung cancer models harboring clinically relvant drug resistance mutations. This provides assurance for the potential integration of FDG-PET imaging in the preclinical and clinical development of effective therapies against NSCLCs
General synthesis of alkylalkenylalkynylboranes via haloboranes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral synthesis of alkylalkenylalkynylboranes via haloboranesHerbert C. Brown, D. Basavaiah, and N. G. BhatCite this: Organometallics 1983, 2, 10, 1468–1470Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October 1983https://pubs.acs.org/doi/10.1021/om50004a043https://doi.org/10.1021/om50004a043research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Severe Gingival Recession Caused by Traumatic Occlusion and Mucogingival Stress: A Case Report (2008)

ABSTRACT Gingival recession is displacement of the soft tissue margin apically leading to root surface exposure. Tooth malpositions, high muscle attachment, frenal pull have been associated with gingival tissue recession. Occlusal trauma is defined as injury resulting in tissue changes within the attachment apparatus as a result of occlusal forces. Trauma from occlusion may cause a shift in tooth position and the direction of the movement depends on the occlusal force. We present the clinical and radiological findings and the limitation of periodontal treatment of a severe gingival recession in a case with traumatic occlusion. A 16 years old male, systemically healthy and nonsmoking patient presented to our clinic with severe gingival recession of mandibular canines and incisors. Clinical evaluation revealed extensive gingival recession on the vestibules of mandibular anterior segment. Patient has an Angle class III malocclusion and deep bite. To maintain the teeth until orthodontic therapy and maxillofacial surgery, mucogingival surgeries were performed to obtain attached gingiva to provide oral hygiene and reduce inflammation. After mucogingival surgeries, limited attached gingiva was gained in this case. Regular periodontal maintenance therapy was performed at 2 month intervals to preserve mandibular anterior teeth. Multidisciplinary approach should be performed in this kind of case for satisfactory results. Unless occlusal relationship was corrected, treatment of severe gingival recession will be problematic. For satisfactory periodontal treatment, early diagnosis of trauma from occlusion and its treatment is very important. (Eur J Dent 2008;2:127-133)
On the Formation of Benzonitrile from Benzaldehyde and Ammonia. II. Iodine as an Oxidant (1967)

Abstract The present authors previously reported a method of synthesizing nitriles from aldehydes by using iodine as an oxidant (Bull. Chem. Soc. Japan, 39, 854 (1966)). The possible route and detailed conditions of this reaction have now been investigated in the case of benzaldehyde; the results will be described in this paper. Benzaldehyde, ammonia, and iodine in methanol react to form benzonitrile and methyl benzoate as the main products. A possible reaction mechanism is suggested by a consideration of the effect of the temperature and of the concentrations of the reactants, and of the effect of the addition of ammonium iodide and water, as well as by a consideration of the results of the reaction starting from hydrobenzamide. The mechanism may be as follows. Iodamine, which is in equilibrium with iodine and ammonia, oxidizes benzilideneimine, which arises from the reaction between benzaldehyde and ammonia to give hydrobenzamide, to produce benzonitrile. Methyl benzoate is produced by the oxidation of the hemiacetal which arises from the reaction between benzaldehyde and methanol. Gyaphenin (2, 4, 6-triphenyl-1, 3, 5-triazine) is found as a by-product, but it is shown not to be produced by the trimerization of benzonitrile.
ChemInform Abstract: Peptide Self‐Assembly Triggered by Metal Ions (2015)

Abstract Review: recent development of structures, functions, as well as strategies of a peptide self‐assembly induced by metal ions; 122 refs.
LETTERS TO THE EDITOR (1948)

Chief of Clinical Investigations “Pabellon Inchauspe de Cardiologia” Hospital Ramos Mejia Buenos Aires, Argentina
Clinico-pathological analysis referring hemeoxygenase-1 in acute fibrinous and organizing pneumonia patients (2015)

Acute fibrinous and organizing pneumonia (AFOP) is a very rare pathological entity of lung injury characterized by intra-alveolar fibrin balls. Hemeoxygenase (HO) -1 is a cytoprotective enzyme against oxidative stress and inflammation. It is known to be expressed in the alveolar macrophages in the healthy adults and overexpressed in other various lung cells of the lung injury patients. We experienced two cases of subacute form AFOP for these 10 years and reviewed clinico-pathological characteristics. The average age was 62 years old and both were male. The etiology of both cases was idiopathic. The average PaO2/FIO2 ratio was 274.5 ± 84.1. The average levels of C-reactive protein and surfactant protein - A of the serum were elevated to 19.8 ± 6.3 mg/dL and 67.6 ± 15.8 ng/mL, respectively. Serum sialylated carbohydrate antigen levels were normal in both cases. The characteristic radiographic findings were bilateral consolidations and ground glass opacities. Lung biopsy specimens revealed fibrin balls and alveolitis with abundant cellular HO-1 expression. Steroid response was excellent and the pulmonary involvements absolutely disappeared for about 3 months.
Observation of an imine intermediate on dehydroquinase by electrospray mass spectrometry (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTObservation of an imine intermediate on dehydroquinase by electrospray mass spectrometryAndrea Shneier, Colin Kleanthous, Ranjit Deka, John R. Coggins, and Chris AbellCite this: J. Am. Chem. Soc. 1991, 113, 24, 9416–9418Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/ja00024a085https://doi.org/10.1021/ja00024a085research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microheterogeneity of <i>N</i>-glycosylation on a stylar self-incompatibility glycoprotein of <i>Nicotiana alata</i> (1995)

Gametophytic self-incompatibility, a mechanism that prevents inbreeding in some families of flowering plants, is mediated by the products of a single genetic locus, the S-locus. The products of the S-gene in the female sexual tissues of Nicotiana alata are an allelic series of glycoproteins with RNase activity. In this study, we report on the microheterogeneity of N-linked glycosylation at the four potential N-glycosylation sites of the S2-glycoprotein. The S-glycoproteins from N.alata contain from one to five potential N-glycosylation sites based on the consensus sequence Asn-Xaa-Ser/Thr. The S2-glycoprotein contains four potential N-glycosylation sites at Asn27, Asn37, Asn38 and Asn 150, designated sites I, II, IV and V, respectively. Site III is absent from the S2-glycoprotein. Analysis of glycopeptides generated from the S2-glycoprotein by trypsin and chymotrypsin digestions revealed the types of glycans and the degree of microheterogeneity present at each site. Sites I (Asn27) and IV (Asn138) display microheterogeneity, site II (Asn37) contains only a single type of N-glycan, and site V (Asn150) is not glycosylated. The microheterogeneity observed at site I on the S2-glycoprotein is the same as that observed at the only site, site I, on the S1-glycoprotein (Woodward et al., Glycobiology, 2, 241-250, 1992). Since the N-glycosylation consensus sequence at site I is conserved in all S-glycoproteins from other species of self-incompatible solanaceous plants, glycosylation at this site may be important to their function. No other post-translational modifications (e.g. O-glycosylation, phosphorylation) were detected on the S2-glycoprotein.
The molecular relaxations in polyurethane networks based on hyperbranched polyesters (2005)

Communication par affiche
Current molecular profile of juvenile nasopharyngeal angiofibroma: First comprehensive study from India (2016)

NA. Laryngoscope, 127:E100-E106, 2017.
Spectral analysis of fluorescence of excited species from 193 nm photoablation of polycarbonate and the high Tc superconductors Bi2CaSr2Cu2O9 and YBa2Cu3O7−d (1989)

Samples are photoablated in a vacuum and the resulting emission spectra are obtained. The relative and absolute line intensities depend upon the number of laser shots. Our observations show that the emission can be used to characterize the bulk materials as well as the films.