gebhart/patrepeval huggingface dataset:
Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain (1988)

The degradation of phosphorylated and dephosphorylated neurofilament proteins by the Ca2+-activated neutral proteinase calpain was studied. Neurofilaments were isolated from bovine spinal cord, dephosphorylated by alkaline phosphatase (from Escherichia coli) and radioiodinated with [125I]-Bolton-Hunter reagent. The radioiodinated neurofilament proteins (untreated and dephosphorylated) were incubated in the presence and absence of calpain from rabbit skeletal muscle, and the degradation rates of large (NF-H), mid-sized (NF-M) and small (NF-L) neurofilament polypeptides were analysed by SDS/polyacrylamide-gel electrophoresis and autoradiography. The degradation of dephosphorylated neurofilament proteins occurred at a higher rate, and to a greater extent, than did that of the phosphorylated (untreated) neurofilament proteins. The dephosphorylated high-molecular-mass neurofilament (NF-HD) was proteolyzed 6 times more quickly than the untreated NF-H. The degradation rate of the NF-M and NF-L neurofilament proteins was also enhanced after dephosphorylation, but less than that of NF-H. This indicates that the dephosphorylation of neurofilament proteins can increase their sensitivity to calpain degradation.
A Traveling-Wave Forward Coupler Design for a New Accelerating Mode in a Silicon Woodpile Accelerator (2015)

Silicon woodpile photonic crystals provide a base structure that can be used to build a 3-D dielectric waveguide system for high-gradient laser-driven acceleration. A new woodpile waveguide design that hosts a phase synchronous centrally confined accelerating mode is proposed. Comparing with previously discovered silicon woodpile accelerating modes, this mode shows advantages in terms of better electron beam loading and higher achievable acceleration gradient. Several traveling-wave coupler design schemes developed for multicell RF cavity accelerators are adapted to the woodpile power coupler design for this new accelerating mode. Design of a forward coupled highly efficient silicon woodpile accelerator is achieved. Simulation shows high efficiency of over 75% of the drive laser power coupled to this fundamental accelerating mode, with less than 15% backward wave scattering. The estimated acceleration gradient, when the coupler structure is driven at the damage threshold fluence of silicon at its operating 1.506-μm wavelength, can reach 185 MV/m. A 17-layer woodpile waveguide structure was successfully fabricated, and the measured bandgap is in excellent agreement with simulation.
A fully flexible stimulator using 65 nm cmos process for 1024-electrode epi-retinal prosthesis (2009)

This paper presents a fully flexible stimulator using 65 nm CMOS process for a 1024-electrode epi-retinal prosthesis. The stimulator can select any number of electrodes at any time and also supports both mono-polar and multi-polar stimulation. Furthermore, the stimulator supports a wide range of stimulus parameters. A novel feature is that the electrode driver operates in an alternately pull-push manner, which helps reduce headroom voltage while guaranteeing charge balance at the active electrode. The use of positive supplies instead of both positive and negative supplies simplifies CMOS circuit design. The current distribution between two nearby simultaneously active electrode groups was investigated and measurement result showed a maximum current crosstalk of 8%.
Marker or mediator? Changes in endotoxin activity as a predictor of adverse outcomes in critical illness (2005)

Introduction Community-acquired pneumonia remains a common condition worldwide. It is associated with significant morbidity and mortality. The aim of this study was to evaluate conditions that could predict a poor outcome. Design Retrospective analyse of 69 patients admitted to the ICU from 1996 to 2003. Demographic data included age, sex and medical history. Etiologic agents, multiorgan dysfunction, nosocomial infections, SAPS II and PORT scores were recorded for each patient. For statistical analysis we used a t test, chi-square test and Mann-Whitney U test on SPSS . A value of P less than 0.05 was considered significant. Results Forty-seven patients were male and 22 patients were female. Mean age was 52 years. Sixty-seven percent had serious pre-morbid conditions including pulmonary disease (34.8%), cardiac problems (36.2%), diabetes (13%) and chronic liver disease (5.8%); 40.6% were smokers, drug abusers or alcohol dependents. Sixtyeight patients required invasive mechanical ventilation. The average length of ventilation was 13.5 days, median 8 days. The mean SAPS II score was 40.14 and the mean PORT score was 141. The mortality rate was 27.5% (SAPS II estimated mortality, 35%). Complications reported were ARDS (40.6%), septic shock (34.8%), acute renal failure (2.9%), cardiac arrest (8.7%) and nosocomial infeccions (46.4%). Mortality rates were higher for previous hepatic (75%) and metabolic (33%) diseases. We found a close association between crude mortality and SAPS II score (P = 0.003) and development of complications (P = 0.0028). Respiratory dysfunction (P = 0.006) and septic shock (P = 0.022) were most significantly related to mortality. No significant differences were founded regarding age, comorbidities, PORT score, etiologic agents, nosocomial infections and length of invasive mechanical ventilation. Conclusions Previous hepatic chronic disease was strictly related to higher mortality as well as isolation of MRSA. ARDS and septic shock predicted a poor outcome. SAPS II score was the best severity indicator of mortality.
Increased ventral striatal monoaminergic innervation in Tourette syndrome (2003)

Previously reported differences between patients with TS and control subjects in dorsal striatal dopamine terminal markers may reflect medication-induced regulation of terminal marker expression or be the result of intrinsic differences in striatal dopaminergic synaptic function. Increased right ventral striatal DTBZ binding suggests that abnormal ventral striatal dopaminergic innervation may underlie tics.
Detection of Low Serum Immunoglobulin Concentrations in Clinically Ill Calves (1999)

The sensitivity, specificity, and accuracy of classification of 4 tests for failure of passive transfer (FPT) were examined in clinically ill neonatal calves. Comparisons were made with serum IgG1 concentrations determined by radial immunodiffusion. Serum samples were obtained from 27 clinically ill calves < or = 21 days of age. The results of 4 commonly used assays, the sodium sulfite turbidity test, the zinc sulfate turbidity test, refractometry, and the serum gamma-glutamyl transferase (GGT) activity test, were compared with radial immunodiffusion determinations of serum IgG1 concentration. Serum GGT activity using a 50 IU/L threshold resulted in correct classification of the highest percentage of calves (93%) with regard to their passive transfer status. The sodium sulfite test with a 1+ end point and refractometry using a 5.5 g/dL end point resulted in correct classification of 85% of the calves studied. When using the sodium sulfite test, the 2+ and 3+ test end points had lower specificity, 0.58 and 0.00, respectively, than the 1+ end point. This loss in specificity resulted in misclassification of calves with adequate serum immunoglobulin concentrations as having FPT. The zinc sulfate turbidity test was inadequately specific (0.33) and resulted in misclassification of 33% of calves.
FACTORS INFLUENCING REINFORCEMENT OF NR AND EPDM RUBBERS WITH SHORT ARAMID FIBERS (2011)

Abstract Among short fiber reinforced composites, those with rubbery matrices have gained great importance due to the advantages they have in processing and low cost, coupled with high strength. These composites combine the elastic behavior of rubbers with strength and stiffness of fibers. Aramid fibers have been chosen because of their significantly higher modulus and strength, compared to other commercial fibers. Compounds based on NR and EPDM are prepared. Short aramid fibers with different kinds of surface treatments, standard finish, and resorcinol formaldehyde latex (RFL)-coating result in different rubber–fiber interfaces. The reinforcing effect of these short aramid fibers is characterized by mechanical and viscoelastic experiments, and by studying the fracture surfaces with electron microscopy techniques. Related to the fiber coating and rubber curing system, sulfur- or peroxide-based, different reinforcement mechanisms are observed, where the combination of peroxide-cured EPDM with RFL-treated fibers is the only case showing clear signs of chemical adhesion. In all other combinations there are only indications of mechanical interactions of the fibers with the rubber matrices, due to bending/buckling of fibers, dog-bone shaped fiber ends, and surface roughness due to the RFL-coating.
Interleukin 4 Induces Cellular Adhesion Among B Lymphocytes (1989)

We here report that interleukin 4 (IL-4) alone is able to induce cellular adhesion among mouse lymphocytes, and together with lipopolysaccharide (LPS), it increases the adhesion induced by LPS. The adhesion was inhibited by antibodies against IL-4. IL-4 appears to be acting mainly on B lymphocytes, since the response caused by IL-4 alone was much less sensitive to depletion of adherent cells than the LPS response. Depletion of T cells had no effect on IL-4- or LPS-induced adhesion. IL-4 could together with Con A, but not alone, induce adhesion among T cells. Cell clusters, which were formed after 2-3 days of LPS plus IL-4 stimulation, could be completely dissociated, and when the cells were recultured in medium, they readily started to reaggregate. The adhesion molecule lymphocyte function-associated antigen 1 (LFA-1) is, at least in part, involved in LPS plus IL-4-induced adhesion. Antibodies against LFA-1 inhibited the adhesion, but antibodies against other cell surface molecules were without inhibitory effect. Adhesion induced by IL-4 alone may involve other adhesion molecules than LFA-1.
Analysis of Enhanced Deployment Models for Sensor Networks (2010)

We present the estimation and evaluation of deployment models for sensor networks that exploit different amounts of a-priori information. Topologies generated from the models exhibit minimum energy consumption at maximum sensing coverage. The applied energy model makes use of measurements obtained from real experiments. We consider general sets of interesting points in the phenomena since those exhibit most of the information content. The estimated models lead to significantly optimized initial network deployments which can be subsequently used with other existing optimization techniques. Overall the energy-efficiency, sensing coverage and operational lifetime of Wireless Sensor Networks (WSNs) are strongly improved by our suggested deployment model. Furthermore, we derive a novel metric from our analysis enabling the estimation of the performance of WSNs. This metric makes use of both measures describing the similarity of probability distributions and measures characterizing spatial correlations.
Synthesis and characterization of a carbon suboxide complex of nickel, (PPh3)2Ni(C,C':.eta.2-C3O2) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of a carbon suboxide complex of nickel, (PPh3)2Ni(C,C':.eta.2-C3O2)Adam K. List, Milton R. Smith III, and Gregory L. HillhouseCite this: Organometallics 1991, 10, 1, 361–362Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/om00047a075https://doi.org/10.1021/om00047a075research-articleACS PublicationsRequest reuse permissionsArticle Views407Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
T-cell Non-Hodgkin's Lymphoma in Adults: Clinicopathological Characteristics, Response to Treatment and Prognostic Factors (2002)

T-cell NHL represent 10-15% of all malignant lymphomas making systematic prospective clinical trials difficult. Therefore, the prognostic significance of the T-cell phenotype has been a matter of controversy in recent years. In a retrospective analysis of 681 patients (pts) with NHL accrued from 1992 to 1997 at a single institution, 66 patients with T-cell NHL were identified. According to the REAL classification, histologies were as follows: 28 peripheral T-cell lymphomas (PTCL), 19 large cell anaplastic lymphoma (LCAL), 12 precursor lymphoblastic lymphoma (Lb), and seven AILD. Multiagent anthracycline containing regimens were used as initial therapy in 91% of cases. T-cell NHL represent 9.8% of all NHL patients at our institution accrued over a 6-year period. Overall response rate was 76%, 21% had progressive disease and 3% died during first line treatment. Mean overall survival (OS) was 8.22 +/- 0.94 years. There was a significant difference in OS between the four different histological subgroups (log rank P=0.0288). LCAL: mean OS 11.05 +/- 1.55 years (95% CI 8.00-14.09); LB: mean OS 7.09 +/- 1.40 years (95% CI 4.33-9.84); PTCL: mean 6.62 +/- 1.17 years (95% CI 4.33-8.90); AILD: 1.54 +/- 0.44 years (95% CI 0.67-2.40). OS was also significantly different for patients classified according to the International Prognostic Index (IPI)-score (log rank P = 0.002). Mean OS for patients with low risk, intermediate low risk, intermediate high risk and high risk was 10.46 +/- 1.02, 6.46 +/- 1.79, 4.50 +/- 1.20 and 1.15 +/- 0.46 years, respectively. Univariate analysis (log-rank test) for prognostic factors also revealed elevated LDH, B-symptoms and extranodal involvement as significant factors for OS. The presence of bulky disease (>7.5 cm), advanced stage III/IV and bone marrow involvement did not influence OS. In conclusion, it is evident that histological subtype and IPI-score have a strong prognostic impact on OS in pts with T-cell NHL. Thus, the distribution of risk factors in patients with T-cell NHL may be more important for OS than T-cell histology per se.
Re: Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: A Prospective Development Study (2016)

No AccessJournal of UrologyAdult Urology1 Aug 2016Re: Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: A Prospective Development Study Samir S. TanejaMD Samir S. TanejaSamir S. Taneja More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.05.070AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: A Prospective Development Study." The Journal of Urology, 196(2), p. 414 © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 196Issue 2August 2016Page: 414 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.MetricsAuthor Information Samir S. Taneja More articles by this author Expand All Advertisement PDF downloadLoading ...
Physical Characteristics and Perceptual Effects of ???Blue-Blocking??? Lenses (1989)

The transmission-optical properties of a "blue-blocking" lens and its influence on several aspects of human visual performance were assessed. Results showed that the lens was effective in absorbing ultraviolet and blue wavelengths and that its effects on contrast sensitivity and visual evoked potentials (VEP's) were similar to those produced by an equivalent neutral density (ND) filter. Although the lens did not alter stereopsis, it did produce severe color discrimination losses for normal and dichromatic subjects.
Property predictions for packed columns using Monte Carlo and discrete element digital packing algorithms (2008)

Chaoshui Xu, Xiaodong Jia, R. A. Williams, Hugh Stitt, S. El-Bachir, Andrew J. Sederman, Lynn F. Gladden and Michiel Nijemeisland
DEFLECTION LIMITS FOR TEMPORARY CONCRETE BARRIERS (REVISED) (2003)

Whenever a traffic control plan is developed that utilizes temporary barriers, it is important to define acceptable barrier deflection criteria. However, the acceptable deflection criteria can be expected to vary, depending on the application. When temporary concrete barriers are used on the edge of a bridge, the risk of the entire line of barriers falling off of the deck requires that deflection limits be selected to preclude such behavior in almost all impact scenarios. Hence, it is recommended that at the edge of a bridge deck, design deflection limits should be selected to contain more than 95% of all crashes. In all other barrier applications, the consequences of a barrier exceeding the design deflection criteria are not severe. In these situations, a more modest deflection limit criterion based on an 85th percentile impact condition is more appropriate. Previous crash testing according to NCHRP Report No. 350 has shown that most temporary barrier systems have produced large lateral deflections, high vehicle climb, and high roll angles when subjected to such an extreme impact. However, it is generally accepted that the Test Level 3 (TL-3) strength test with a 3/4-ton pickup truck represents an extreme impact severity that is infrequently encountered in real world accidents. Additional crash tests could be conducted to determine the deflection of temporary barriers at reduced impact condition but the cost would be extremely high. Therefore, computer simulation was used to estimate the deflection of barriers impacted under the 85th percentile impact conditions. Finally, recommendations were made pertaining to the two different design deflection limits that should be used for the Iowa temporary concrete barrier.
An <i>in vivo</i> model to study the pathobiology of infectious biofilms on biomaterial surfaces (1991)

This study examines the morphology, ultrastructure, and microbiology of the intact biofilm developing on an implant surface. Silastic subdermal implant material was colonized with P. aeruginosa and surgically inserted into the peritoneal cavity of adult rabbits. After 4, 8, 28, and 42 days implants were recovered and the intact biofilms examined. P. aeruginosa colonized the implant throughout the entire experimental time. Microcolonies of glycocalyx-coated bacteria were observed within the biofilm. However, the bulk of the biofilm was host-generated and typically contained phagocytes trapped within a thick mesh of fibrin. Polymorphonuclear neutrophils were the predominant cell type. Isolated erythrocytes, macrophages, and fibroblasts were also observed. By day 28, the biofilm was enclosed in a fibrous capsule of vascularized connective tissue. The low numbers of neutrophils seen in biofilms from sterile Silastic sheets implanted into control animals suggested that neutrophilia may represent a specific cellular response to the bacterial colonization. The results indicate that the cell-mediated immune response provides for most of the biofilm mass on colonized implant surfaces. Inactivated phagocytes trapped in fibrin may "wall-off" the embedded bacterial microcolonies and thus shield them from live phagocytic leucocytes. Such a mechanism may play an important role in the pathogenesis of prosthetic device infections.
Determination of Settling Tanks Performance Using an Eulerian- Lagrangian Method (2008)

Circulation regions always exist in settling tanks. These regions reduce the tank's performance and decrease its effective volume. The recirculation zones would result in short-circuiting and high flow mixing problems. The inlet position would also affect the size and location of the recirculation region. Using a proper baffle configuration could substantially increase the performance of the settling tanks. A common procedure for the comparison of the performances of different tanks has been using the Flow Through Curves (FTC) method. FTC, however, neglects tendencies for particles sedimentation. In this work, a new method for evaluation of the settling tanks performance is presented. The new method which is referred to as the particle Tracking Method (PTM) is based on an Eulerian-Lagrangian approach. In this paper, by using FTC and PTM the effects of the inlet position and the baffle configuration on the hydraulic performance of the primary settling tanks were studied and results were compared. Then, shortcomings of the FTC approach were stated. The optimal positioning of the baffles was also determined though a series of computer simulations.
Brain-Swarm Control Interfaces: The Transition from Controlling One Robot to a Swarm of Robots (2017)

Brain-Machine Interfaces (BMIs) have been one of the most influential and disruptive science fields of the past decades. Prosthetic or remotely operated robotic devices being controlled by brain signals has transitioned from science fiction to reality. Advances in the recording electrodes technology and the machine learning and signal decoding algorithms were critical in the realization of those systems. The second decade of the 21st century brings new challenges found in both frontiers; first, advancements in neuroscience are sought via high-resolution mapping of the brain for better understanding of its function and decision making processes. On the robotics frontiers, the challenge of the human controlling many robots simultaneously is of utmost importance for applications spanning from industrial and entertainment, to disaster response and military. As the swarming paradigm, deriving inspiration from the behaviour of natural swarms such as bird flocks and fish schools, offers myriad advantages to a team of robots, the way humans interact and control a robotic swarm creates new avenues of research. This article summarizes recent developments and novel methods for brain-swarm interfaces, and poses challenges for the future researchers.
Development of a Non-Radiographic Spall and Damage Diagnostic (2004)

A new, non‐radiographic diagnostic has been developed that appears to provide information on multiple spall and damage layers in metals. The velocities of multiple layers (up to 5 in copper) can be determined using this method, with additional information possible on damaged material between layers at densities less than the bulk metal value. Metals that are melted on release (tin) also seem to exhibit a distinctive signature that is quite different from conventional multi‐layer spall. Experimental results on these metals and proton radiographs confirming these results are also presented.
ChemInform Abstract: Studies in the 2‐Hetarylbenzimidazole Series. Part 8. Synthesis and Properties of 1‐Methyl‐2‐(5‐methylselenophen‐2‐yl)benzimidazole. (1988)

Abstract Cyclization of the selenophenecarboxaldehyde (II) with o‐phenylenediamine (I) gives the selenophen‐2‐ylbenzimidazole (III) which is methylated, producing the title compound (V).