gebhart/patrepeval huggingface dataset:
Disability support pension: Whether payable; meaning of course of rehabilitation: SAMMUT and secretary to the DFHCSIA (2013)

Sammut was in receipt of a disability support pension (DSP) from 25 August1994. He was charged with an offence and detained on 30 May 2011. His DSP was suspended on 31 May 2011. He was released from custody on 13 October2011 and his DSP was restored. On 17October 2011, Sammut requested that his DSP be restored from 20 July 2011the date when he said he was ordered to be released from custody to a mental health facility. On 16 November 2011the original decision maker decided that the decision not to restore his DSP until 13 October 2011 was correct. This decision was upheld by an authorised review officer on 20 December 2011 and affirmed by the Social Security Appeals Tribunal (SSAT) on 27 February 2012.On 22 March 2012, Sammut lodged an application for review with the Tribunal.
The secret life of extracellular vesicles in metal homeostasis and neurodegeneration (2015)

Biologically active metals such as copper, zinc and iron are fundamental for sustaining life in different organisms with the regulation of cellular metal homeostasis tightly controlled through proteins that coordinate metal uptake, efflux and detoxification. Many of the proteins involved in either uptake or efflux of metals are localised and function on the plasma membrane, traffic between intracellular compartments depending upon the cellular metal environment and can undergo recycling via the endosomal pathway. The biogenesis of exosomes also occurs within the endosomal system, with several major neurodegenerative disease proteins shown to be released in association with these vesicles, including the amyloid-β (Aβ) peptide in Alzheimer's disease and the infectious prion protein involved in Prion diseases. Aβ peptide and the prion protein also bind biologically active metals and are postulated to play important roles in metal homeostasis. In this review, we will discuss the role of extracellular vesicles in Alzheimer's and Prion diseases and explore their potential contribution to metal homeostasis.
Correlations between Self-Interstitials and Vacancies during Thermal Oxidation in Silicon (1991)

It is generally accepted that there are four relations between self-interstitials and vacancies during thermal oxidation in silicon; local equilibrium between self-interstitials and vacancies, oxidation-enhanced and -retarded diffusions (OED and ORD) and oxidation stacking faults (OSF). From a mathematical point of view on these relations, a method for their analysis was established. The results of this study clearly indicate some OED, ORD and OSF to be governed by only an interstitialcy or vacancy mechanism. A method for obtaining analytical solutions is also discussed.
The Cytoprotective Effects of Dantrolene (2010)

Calcium, as a second messenger, has an important role in a variety of cellular functions. However, disruption of intracellular calcium homeostasis leads to cytotoxicity and cell death. Excessive calcium release from intracellular stores, via the calcium channel ryanodine receptor, contributes to cell damage. Dysfunction of calcium homeostasis is established in tissue culture and animal models of ischemia, hypoxia, seizure, trauma, anesthesia, and neurodegenerative diseases. Dantrolene, the primary drug to treat malignant hyperthermia, is a ryanodine receptor antagonist. Dantrolene inhibits abnormal calcium release from the sarco-endoplasmic reticulum, which is the primary intracellular calcium store. Dantrolene has been investigated widely for its possible cytoprotective effects against cell damage in different tissue culture or animal models of diseases involving cytotoxicity induced by disruption of intracellular calcium homeostasis in pathogenesis. In this review, we summarize the role of the disruption of intracellular calcium homeostasis on cell death, the pharmacologic and pharmacokinetic features of dantrolene, and the cytoprotective effects and potential application of dantrolene for the inhibition of cell damage in a wide variety of models of stress and disease.
Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2 (2018)

Myocardial ischemia-reperfusion (I/R) injury remains the leading risk factor of disability and mortality worldwide. In this study, the myocardial protective effect of eriodictyol (EDT) and the underlying mechanism in an <i>ex vivo</i> model of global myocardial I/R was investigated. After treatment with different concentrations of EDT, the decreased hemodynamic parameters induced by myocardial I/R injury were significantly attenuated by EDT. The elevated levels of IL-6, CRP, IL-8, and TNF-α were effectively reduced by EDT treatment. EDT also remarkably suppressed the levels of Bax and cleaved Caspase-3, and up-regulated the level of Bcl-2 in cardiac tissues from EDT-treated groups. Further studies showed that EDT could increase the levels of p-JAK2 and p-STAT3 in cardiac tissues. Meanwhile, treatment of AG490, a specific inhibitor of JAK2, abolished the protective effect of EDT on hemodynamic parameters, myocardial inflammation and myocardial cell apoptosis induced by I/R injury. These results demonstrated that EDT could protect against myocardial I/R injury through the activation of JAK2, providing a potential treatment with EDT during myocardial I/R injury.
Evaluation of Imipenem/Imipenem+EDTA Disk Method for Detection of Metallo- <i>β</i> -Lactamase-producing <i>Klebsiella pneumoniae</i> Isolated from Blood Cultures (2006)

The objective of this study was to evaluate the imipenem (IMP) and IMP+EDTA (IMP/IMP+EDTA) disk method for the detection of metallo-beta-lactamases (MBLs) in clinical isolates of Klebsiella pneumoniae with various MIC levels to IMP. Forty-one blood isolates of K. pneumoniae with MIC to IMP ranging from < or =0.5 to > or =16 microg/ml were examined. The MICs were determined by VITEK-2 (bioMerieux Vitek two, France). Disks of 10 microg IMP with and without the addition of 0.5 M EDTA were used for the IMP/IMP+EDTA disk method. The E-test (AB Biodisk, Solna, Sweden) for MBL detection was also used. All isolates were examined for the bla (VIM-1) gene by PCR and for clonality of VIM-1-producing isolates by pulsed-field gel electrophoresis (PFGE). All isolates with MIC values of IMP < or =0.5 microg/ml exhibited no differences in inhibition zone diameters (IZD) produced by IMP and IMP+EDTA disks, whereas the isolates with MICs > or =1 microg/ml showed an increase in IZD, ranging from 8 to 26 mm. All isolates with MIC values of > or =1 microg/ml were found positive for the bla (VIM-1) gene by PCR and for MBL production by the E-test, whereas none of isolates with MICs <0.5 microg/ml was found positive by any of the tests. DNA restriction fragments generated by PFGE of VIM-1-producing isolates were classified in four main types. The IMP/IMP+EDTA disk method is simple to perform, sensitive, and specific for detection of MBL-producing K. pneumoniae clinical isolates. K. pneumoniae isolates with MICs of IMP > or =1 microg/ml and/or IZD produced by IMP disk <19 mm should be tested for MBL production.
Combined LTP and LTD of Modulatory Inputs Controls Neuronal Processing of Primary Sensory Inputs (2011)

A hallmark of brain organization is the integration of primary and modulatory pathways by principal neurons. However, the pathway interactions that shape primary input processing remain unknown. We investigated this problem in mouse dorsal cochlear nucleus (DCN) where principal cells integrate primary, auditory nerve input with modulatory, parallel fiber input. Using a combined experimental and computational approach, we show that combined LTP and LTD of parallel fiber inputs to DCN principal cells and interneurons, respectively, broaden the time window within which synaptic inputs summate. Enhanced summation depolarizes the resting membrane potential and thus lowers the response threshold to auditory nerve inputs. Combined LTP and LTD, by preserving the variance of membrane potential fluctuations and the membrane time constant, fixes response gain and spike latency as threshold is lowered. Our data reveal a novel mechanism mediating adaptive and concomitant homeostatic regulation of distinct features of neuronal processing of sensory inputs.
CD8+CD122+ T-Cells: A Newly Emerging Regulator with Central Memory Cell Phenotypes (2015)

CD8(+)CD122(+) T-cells have been traditionally described as antigen-specific memory T-cells that respond to previously encountered antigens more quickly and vigorously than their naïve counterparts. However, mounting evidence has demonstrated that murine CD8(+)CD122(+) T-cells exhibit a central memory phenotype (CD44(high)CD62L(high)), regulate T cell homeostasis, and act as regulatory T-cells (Treg) by suppressing both autoimmune and alloimmune responses. Importantly, naturally occurring murine CD8(+)CD122(+) Tregs are more potent in immunosuppression than their CD4(+)CD25(+) counterparts. They appear to be acting in an antigen-non-specific manner. Human CD8(+)CXCR3(+) T-cells are the equivalent of murine CD8(+)CD122(+) Tregs and also exhibit central memory phenotypes. In this mini-review article, we will summarize recent progresses in their phenotypes, homeostatic expansion, antigen-specificity, roles in the suppression of alloimmune and autoimmune responses, and the mechanisms underlying their inhibitory function.
Remazol Brilliant Blue as a pre-stain for the immediate visualization of human serum proteins on polyacrylamide gel disc electrophoresis. (1983)

We describe the pre-staining of proteins in normal human serum with Remazol Brilliant Blue before separation by disc electrophoresis. Critical to reproducibility are: dye concentration of 0.16 mol/L in a Tris-glycine buffer (pH 8.3), use of equal volumes of serum and dye solution, a tagging period of 2 h at room temperature, and electrophoresis of 0.1 mL of the mixture at 2.5 mA/gel for about 2 h. Advantages include speed, quality of resolution, and low background. This method was compared with Amido Black post-electrophoresis staining in 35 sera. Of these, 16 showed identical results with respect to the number of bands. In the other 19, Amido Black showed more bands in the post-transferrin region and, sometimes, in the post-albumin region. The pre-stained gels showed slower electrophoretic mobilities of the components. Protein bands eluted from pre-stained gels retained immunological reactivity.
Predicting Flicker Thresholds for Video Display Terminals (1987)

Abstract-This paper describes an analytical method for predicting whether a video display terminal will appear to flicker given the screen phosphor persistence, refresh frequencies, and other environmental fac-tors such as ambient light level, the distance between the viewer and the display, etc. From the method, one can predict the maximum screen luminance and the minimum refresh frequency that will generate a flicker-free display for a theoretical standard observer. These predictions are tested across a wide range of refresh frequencies, screen luminances, screen phosphors, and individual users. I. BACKGROUND Operators of video display terminals (VDTs) frequently complain of disturbing screen flicker. As a result, several standards require VDTs to be &quot;flicker-free&quot;. Unfortunate-ly, current VDT standards do not specify how to define or design a flicker-free display. This poses a problem for
Application of microCT to the non-destructive testing of an additive manufactured titanium component (2015)

In this paper the application of X-ray microCT to the non-destructive testing of an additive manufactured titanium alloy component of complex geometry is demonstrated. Additive manufacturing of metal components is fast growing and shows great promise, yet these parts may contain defects which affect mechanical properties of the components. In this work a layered form of defect is found by microCT, which would have been very difficult or impossible to detect by other non-destructive testing methods due to the object complexity, defect size and shape and because the pores are entirely contained inside the object and not connected to the surface. Additionally, this test part was subjected to hot isostatic pressing (HIPPING) and subsequently scanned. Comparing before and after scans by alignment of the volumes allows visualization and quantification of the pore size changes. The application of X-ray microCT to additive manufacturing is thus demonstrated in this example to be an ideal combination, especially for process improvements and for high value components.
A library of constructive skeletons for sequential style of parallel programming (2006)

With the increasing popularity of parallel programming environments such as PC clusters, more and more sequential programmers, with little knowledge about parallel architectures and parallel programming, are hoping to write parallel programs. Numerous attempts have been made to develop high-level parallel programming libraries that use abstraction to hide low-level concerns and reduce difficulties in parallel programming. Among them, libraries of parallel skeletons have emerged as a promising way towards this direction. Unfortunately, these libraries are not well accepted by sequential programmers, because of incomplete elimination of lower-level details, ad-hoc selection of library functions, unsatisfactory performance, or lack of convincing application examples. This paper addresses principle of designing skeleton libraries of parallel programming and reports implementation details and practical applications of a skeleton library SkeTo. The SkeTo library is unique in its feature that it has a solid theoretical foundation based on the theory of Constructive Algorithmics, and is practical to be used to describe various parallel computations in a sequential manner.
Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets (2006)

The corepressor BCOR potentiates transcriptional repression by the proto-oncoprotein BCL6 and suppresses the transcriptional activity of a common mixed-lineage leukemia fusion partner, AF9. Mutations in human BCOR cause male lethal, X-linked oculofaciocardiodental syndrome. We identified a BCOR complex containing Polycomb group (PcG) and Skp-Cullin-F-box subcomplexes. The PcG proteins include RING1, RYBP, NSPC1, a Posterior Sex Combs homolog, and RNF2, an E3 ligase for the mono-ubiquitylation of H2A. BCOR complex components and mono-ubiquitylated H2A localize to BCL6 targets, indicating that the BCOR complex employs PcG proteins to expand the repertoire of enzymatic activities that can be recruited by BCL6. This also suggests that BCL6 can target PcG proteins to DNA. In addition, the BCOR complex contains components of a second ubiquitin E3 ligase, namely, SKP1 and FBXL10 (JHDM1B). We show that BCOR coimmunoprecipitates isoforms of FBXL10 which contain a JmjC domain that recently has been determined to have histone H3K36 demethylase activity. The recruitment of two distinct classes of E3 ubiquitin ligases and a histone demethylase by BCOR suggests that BCOR uses a unique combination of epigenetic modifications to direct gene silencing.
Sensitive and Selective Chromogenic Sensing of Carbon Monoxide via Reversible Axial CO Coordination in Binuclear Rhodium Complexes (2011)

The study of probes for CO sensing of a family of binuclear rhodium(II) compounds of general formula [Rh(2){(XC(6)H(3))P(XC(6)H(4))}(n)(O(2)CR)(4-n)]·L(2) containing one or two metalated phosphines (in a head-to-tail arrangement) and different axial ligands has been conducted. Chloroform solutions of these complexes underwent rapid color change, from purple to yellow, when air samples containing CO were bubbled through them. The binuclear rhodium complexes were also adsorbed on silica and used as colorimetric probes for "naked eye" CO detection in the gas phase. When the gray-purple colored silica solids containing the rhodium probes were exposed to air containing increasing concentrations of CO, two colors were observed, in agreement with the formation of two different products. The results are consistent with an axial coordination of the CO molecule in one axial position (pink-orange) or in both (yellow). The crystal structure of 3·(CO) ([Rh(2){(C(6)H(4))P(C(6)H(5))(2)}(2)(O(2)CCF(3))(2)]·CO) was solved by single X-ray diffraction techniques. In all cases, the binuclear rhodium complexes studied showed a high selective response to CO with a remarkable low detection limit. For instance, compound 5·(CH(3)CO(2)H)(2) ([Rh(2){(m-CH(3)C(6)H(3))P(m-CH(3)C(6)H(4))(2)}(2)(O(2)CCH(3))(2)]·(CH(3)CO(2)H)(2)) is capable of detection of CO to the "naked eye" at concentrations as low as 0.2 ppm in air. Furthermore, the binding of CO in these rhodium complexes was found to be fully reversible, and release studies of carbon monoxide via thermogravimetric measurements have also been carried out. The importance of the silica support for the maintenance of the CO-displaced L ligands in the vicinity of the probes in a noninnocent manner has been also proved.
Heteroarenobenzodiazepines. Part 7. Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b] and [4,3-b][1,5]benzodiazepines as potential anxiolytics (1989)

The synthesis and pharmacological evaluation of a series of pyrazolo[b][1,5]benzodiazepines are described. Some of the 4-piperazinyl-2,10-dihydropyrazolo[3,4-b][1,5]benzodiazepine derivatives demonstrated potent anxiolytic activity in the three-part operant anticonflict test in rats. Compounds 21 and 30 were more active than the clinically effective anxiolytic chlordiazepoxide in releasing conflict-suppressed behavior. This study shows a dissociation of the anxiolytic and antidopaminergic activities found in the thieno- and dibenzodiazepine derivatives flumezapine and clozapine, respectively. Examples of the three other dihydropyrazolo[b][1,5]benzodiazepine ring systems are described and evaluated for comparison and were found to be less active.
Parallel co-simulation using virtual synchronization with redundant host execution (2006)

In traditional parallel co-simulation approaches, the simulation speed is heavily limited by time synchronization overhead between simulators and idle time caused by data dependency. Recent work has shown that the time synchronization overhead can be reduced significantly by predicting the next synchronization points more effectively or by separating trace-driven architecture simulation from trace generation from component simulators. The latter is known as virtual synchronization technique. In this paper, we propose redundant host execution to minimize the simulation idle time caused by data dependency in simulation models. By combining virtual synchronization and redundant host execution techniques we could make parallel execution of multiple simulators a viable solution for fast but cycle-accurate co-simulation. Experiments show about 40% performance gain over a technique which uses virtual synchronization only
Capacity of a band-limited CDMA MMSE receiver-based system when combined with trellis or convolutional coding (2000)

This paper examines the achievable capacity of a direct-sequence spread-spectrum multiple-access system based on an adaptive minimum mean-square-error (MMSE), single-user receiver over a Gaussian channel. The effect of using both trellis and convolutional codes of varying rates and complexity is investigated in relation to the effect on the maximum number of users and the achievable bit-error rate for a given number of users. A system based on a matched filter receiver is presented for the purposes of comparison. It has been found that, over the band-limited channel considered, the use of convolutional coding reduces the total system capacity for the high efficiency MMSE receiver while still providing a coding gain for a small numbers of users. The use of trellis codes however leads to increased system capacity.
Producing cloud free and cloud-shadow free mosaic from cloudy IKONOS images (2004)

The Southeast Asia region is always under partial or complete cloud covers. As a result, optical remote sensing images of this region always contain cloud covers and associated shadows. In this paper, we report an operational method for generating a "cloud-free" image mosaic of 1-m resolution IKONOS images. The inputs are several cloudy images acquired by the IKONOS satellite over an area of interest. This technique is especially useful in tropical regions with persistent and extensive cloud cover.
Rapid Granulation Tissue Regeneration by Intracellular ATP Delivery-A Comparison with Regranex (2014)

This study tests a new intracellular ATP delivery technique for tissue regeneration and compares its efficacy with that of Regranex. Twenty-seven adult New Zealand white rabbits each underwent minimally invasive surgery to render one ear ischemic. Eight wounds were then created: four on the ischemic and four on the normal ear. Two wounds on one side of each ear were treated with Mg-ATP encapsulated lipid vesicles (ATP-vesicles) while the two wounds on the other side were treated with Regranex. Wound healing time was shorter when ATP-vesicles were used. The most striking finding was that new tissue growth started to appear in less than 1 day when ATP-vesicles were used. The growth continued and covered the wound area within a few days, without the formation of a provisional matrix. Regranex-treated wounds did not have this growth pattern. In wounds treated by ATP-vesicles, histologic studies revealed extremely rich macrophage accumulation, along with active proliferating cell nuclear antigen (PCNA) and positive BrdU staining, indicating in situ macrophage proliferation. Human macrophage culture suggested direct collagen production. These results support an entirely new healing process, which seems to have combined the conventional hemostasis, inflammation, and proliferation phases into a single one, thereby eliminating the lag time usually seen during healing process.
A Weighted CSP approach for solving spatio-temporal farm planning problems (2012)

Abstract. Applications regarding the crop allocation problem (CAP) are required tools for agricultural advisors to design more efficient farming systems. Despite this issue has been extensively treated by agronomists in the past, few methods tackle the crop allocation problem considering both the spatial and the temporal aspects of the CAP. In this paper, we precisely propose an original approach based on weighted CSP (WCSP) to address the crop allocation planning problem while taking farmers’ management choices into account. These are represented as hard and preference constraints. We illustrate our proposition by some results based on a virtual case study. This preliminary work foreshadows the development of a decision-aid tool for supporting farmers in their crop allocation strategies.
Imaging bacterial 3D motion using digital in-line holographic microscopy and correlation-based de-noising algorithm (2014)

Better understanding of bacteria environment interactions in the context of biofilm formation requires accurate 3-dimentional measurements of bacteria motility. Digital Holographic Microscopy (DHM) has demonstrated its capability in resolving 3D distribution and mobility of particulates in a dense suspension. Due to their low scattering efficiency, bacteria are substantially difficult to be imaged by DHM. In this paper, we introduce a novel correlation-based de-noising algorithm to remove the background noise and enhance the quality of the hologram. Implemented in conjunction with DHM, we demonstrate that the method allows DHM to resolve 3-D E. coli bacteria locations of a dense suspension (>10<sup>7</sup> cells/ml) with submicron resolutions (<0.5 µm) over substantial depth and to obtain thousands of 3D cell trajectories.
Sorbent Nanotechnologies for Water Cleaning (2017)

University of Minnesota Ph.D. dissertation. July 2017. Major: Bioproducts/Biosystems Science Engineering and Management. Advisor: Abdennour Abbas. 1 computer file (PDF); x, 96 pages.