gebhart/patrepeval huggingface dataset:
Effects of the callipyge phenotype on serum creatinine, total cholesterol, low-density lipoproteins, very-low-density lipoproteins, high-density lipoproteins, and triacylglycerol in growing lambs. (1996)

The goals of this study were to investigate the effects of the callipyge (CLPG) phenotype on serum creatinine and lipid profiles of growing lambs. Preliminary studies in our laboratories indicated that creatinine may have utility in distinguishing the CLPG phenotype and that expression of the CLPG gene altered concentrations of serum total cholesterol (TC). As a result, in this study, we examined the influence of the CLPG gene on concentrations of creatinine, TC, very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL), high-density lipoproteins (HDL), and triacylglycerol (TG) at varying stages of maturity in lambs. Ten homozygous (c/c) Polypay ewes were crossed with Dorset rams heterozygous for the CLPG gene (C/c). From this cross, 20 lambs (13 females and 7 males) were born, of which 11 were homozygotic (c/c) and 9 were heterozygotic (C/c; CLPG) based on muscle weights and longissimus dorsi (LD) area at slaughter. Blood samples were taken at monthly intervals and serum lipid constituents were assayed. At 1 mo of age, no differences (P > .05) in plasma lipids were detectable between phenotypes. However, at 2 mo age, CLPG lambs had higher (P < .01) concentration of TG, TC, HDL, and VLDL compared to homozygotic (c/c) lambs. Triglycerides and VLDL were elevated (P < .05) in CLPG lambs at 3 mo of age. By slaughter, no differences (P > .05) in serum lipid constituents were detectable between genotypes. Hence, the increase in serum TC is due to elevated levels of HDL and VLDL. These observations indicate that creatinine may be used to distinguish CLPG lambs and that the CLPG gene alters serum lipid profiles during the postnatal period.
Postoperative Radiotherapy in Pathological T2–3N0M0 Thoracic Esophageal Squamous Cell Carcinoma: Interim Report of a Prospective, Phase III, Randomized Controlled Study (2020)

The value of adjuvant radiotherapy for patients with node-negative esophageal cancer is not clear. The interim results of this phase III study indicated that postoperative radiotherapy significantly improved disease-free survival and decreased local-regional recurrence rate in patients with pathological T2-3N0M0 thoracic esophageal squamous cell carcinoma compared with surgery alone with acceptable toxicities. The distant metastasis rates and overall survival rates were not different between the two groups. Adjuvant radiotherapy should be considered for pathologic T2-3N0M0 thoracic esophageal squamous cell carcinoma. Prospective trials to identify high-risk subgroups are needed.
Pulmonary Capillary Pressure Measurement During Global Hypoxia in Sheep (1993)

Analysis of the pressure decay following pulmonary artery occlusion can be used to determine pulmonary capillary pressure and to calculate the magnitudes of the arterial and venous components of pulmonary vascular resistance. The separation of pulmonary vascular resistance into components has been termed "the longitudinal distribution of pulmonary vascular resistance" to emphasize the fact that different pressures occur at a number of sites in the pulmonary circulation. The longitudinal distribution of pulmonary vascular resistance is closely related to pulmonary capillary pressure. Several methods of data analysis have been proposed to determine pulmonary capillary pressure from the pressure decay following pulmonary artery occlusion. In this study, three methods of data analysis were applied to the model of hypoxic pulmonary vasoconstriction to evaluate the validity of the methodology in a well known model. Pulmonary artery occlusion pressure decay curves were obtained from eight halothane-anesthetized sheep during control conditions (FIO2 = 0.99) and during hypoxic ventilation (FIO2 = 0.14). Analysis of the pulmonary artery occlusion pressure decay curves indicated the following results: 1) Hypoxia increased mean pulmonary artery pressure by 105% and increased pulmonary vascular resistance by 149%; 2) the increase in the calculated arterial component of pulmonary vascular resistance accounted for 88% of the increase in pulmonary vascular resistance with hypoxia; and 3) hypoxia produced only a 1.0 mm Hg increase in pulmonary capillary pressure. These results are consistent with other evidence showing that hypoxia primarily produces precapillary pulmonary vasoconstriction and has little effect on pulmonary capillary pressure. Pulmonary artery occlusion pressure decay curve analysis appears to be a valid technique for the measurement of pulmonary capillary pressure during hypoxia in intact anesthetized animals.
Todilto Formation: A Jurassic Salina and Its Petroleum Potential in East-Central New Mexico: ABSTRACT (1986)

Todilto Formation of northern New Mexico and southwestern Colorado was deposited during the Middle Jurassic (middle Callovian) by a landlocked, saline lake (salina) developed in the Entrada erg. Evaporative pumping drew marine water from the Curtis sea in eastern Utah, which percolated through porous Entrada dune sands into the salina basin. The Todilto salina deposited organic-rich limestone (source rock) within a porous eolian sandstone (reservoir rock). In the San Juan basin, organic-rich Todilto limestones are a primary source of Entrada oil. There, the Todilto Limestone is generally overlain by a thick, impermeable gypsum sequence that allows Todilto hydrocarbons to migrate only into the underlying Entrada. In east-central New Mexico, the Todilto limestones pinch out into the Entrada and are not overlain by gypsum. Therefore, Todilto hydrocarbons should migrate either into the main Entrada body below the Todilto or into the Exeter member of the Entrada above. The Todilto/Entrada in east-central New Mexico has generally been overlooked in oil exploration because of its limited outcrop area and because burial depths did not seem sufficient for hydrocarbon maturation. However, until the late Cenozoic, the Todilto probably was continuous from western Quay County to the Four Corners, and east-central New Mexico was coveredmore » by a thick sequence of Cretaceous marine rocks. Furthermore, migrating Todilto hydrocarbons need not be restricted to existing Todilto outcrops, but may be expected up Entrada paleodip wherever porosity and stratigraphic traps allow accumulation.« less
Automated Biomarker Extraction from Medical Images: An application to the extraction of biomarkers for Alzheimer's disease from brain magnetic resonance imaging (MRI) (2011)

Medical images are widely available to support clinical decision making. This book describes how computer-aided feature extraction techniques can help to obtain biomarkers from medical images that relate to a certain clinical state or the disease progression of individual patients. Different techniques are presented for the example of biomarkers for Alzheimer's disease extracted from brain magnetic resonance imaging (MRI). The first part of the book deals with the automated measurement of traditional morphometric biomarkers. In particular, methods to determine hippocampal volume and hippocampal atrophy are described. In the second part, more data-driven approaches for biomarker extraction based on novel machine-learning techniques are discussed. One application area for the described biomarkers is the selection of subjects in large-scale clinical trials. Other areas include the incorporation of biomarkers into computer aided diagnosis (CAD) systems and the measurement of effects in clinical trials. All described methods are evaluated on a large MRI study on Alzheimer's disease.
POLYTHIOLESTERS. II. PREPARATION IN EMULSIONS (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPOLYTHIOLESTERS. II. PREPARATION IN EMULSIONSC. S. MARVEL and EUGENE A. KRAIMANCite this: J. Org. Chem. 1953, 18, 6, 707–714Publication Date (Print):June 1, 1953Publication History Published online1 May 2002Published inissue 1 June 1953https://pubs.acs.org/doi/10.1021/jo01134a016https://doi.org/10.1021/jo01134a016research-articleACS PublicationsRequest reuse permissionsArticle Views392Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Papain Inhibitions by Optically Active E-64 Analogs (1981)

Modification of E-64 focused on the terminal agmatine for practical use led to some potent analogs which were successfully obtained by a stereoselective synthesis using D-tartaric acid as a starting material. Ep-475 (id. E-64-c), in which the agmatine was replaced by 3-methyl-butylamine, was found to react with the essential SH of papain in accord with the decrease of activity. [3H]Ep-475 was irreversibly incorporated into papain in an equimolar ratio. None of the analogs showed any effect on thiol enzymes other than proteolytic ones.
Body temperatures of fish feeding in the Point Beach thermal discharge (1974)

Between April and November, 1973, measurements of internal body temperature were made on 1310 fish caught by fishermen at the Point Beach Nuclear Plant. Records were also made of fish weight, length, and sex and intake and discharge temperatures. A table is presented to show mean monthly body temperatures and numbers of each species. Approximately 76 percent of the measurements were made on rainbow and brown trout, since these species accounted for 74 percent of the catch. Body temperatures of most fish were intermediate between intake and discharge temperatures. Results suggested that each species has rather specific seasonal temperature requirements and that the maximum discharge temperature was normally avoided by feeding fish. (HLW)
Role of surface residues in conformational stability of human lysozyme (2000)

Conference Abstract| October 01 2000 Role of surface residues in conformational stability of human lysozyme J. Funahashi; J. Funahashi 13–2 Yamadaoka, Suita, Osaka 565–0871, JAPAN Search for other works by this author on: This Site PubMed Google Scholar K. Takano; K. Takano 13–2 Yamadaoka, Suita, Osaka 565–0871, JAPAN Search for other works by this author on: This Site PubMed Google Scholar Y. Yamagata; Y. Yamagata 13–2 Yamadaoka, Suita, Osaka 565–0871, JAPAN Search for other works by this author on: This Site PubMed Google Scholar M. Nakasako; M. Nakasako 13–2 Yamadaoka, Suita, Osaka 565–0871, JAPAN Search for other works by this author on: This Site PubMed Google Scholar K. Yutani K. Yutani 13–2 Yamadaoka, Suita, Osaka 565–0871, JAPAN Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A410. https://doi.org/10.1042/bst028a410c Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation J. Funahashi, K. Takano, Y. Yamagata, M. Nakasako, K. Yutani; Role of surface residues in conformational stability of human lysozyme. Biochem Soc Trans 1 October 2000; 28 (5): A410. doi: https://doi.org/10.1042/bst028a410c Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Correlation of dynamic dielectric measurements with viscosity in polymeric resin systems (1985)

Dynamic dielectric analysis has been used to study curing polymer systems and thermoplastics. Measurements have been made over a frequency range of six decades. This wide range of frequencies increases the amount of information which can be obtained. The data are analyzed in terms of the frequency dependence of the specific conductivity sigma and the relaxation time tau, parameters which are characteristic of the cure state of the material and independent of size of the sample. Dynamic dielectric measurements have been correlated with viscosity for the polysulfone thermoplastic UDEL-P1700 and with viscosity and ultrasonic measurements on the DGEBA-type epoxy Epon 828 cured with Agent U. The experimental results suggest that when ionic processes dominate the dielectric response, the intensive property sigma is a good monitor of the resin's viscosity. The results show that the dielectric relaxation time tau can be used to monitor the state of the system and the extent and rate of the reaction.
Measuring and Predicting the Internal Structure of Semiconductor Nanocrystals through Raman Spectroscopy (2016)

Nanocrystals composed of mixed chemical domains have diverse properties that are driving their integration in next-generation electronics, light sources, and biosensors. However, the precise spatial distribution of elements within these particles is difficult to measure and control, yet profoundly impacts their quality and performance. Here we synthesized a unique series of 42 different quantum dot nanocrystals, composed of two chemical domains (CdS:CdSe), arranged in 7 alloy and (core)shell structural classes. Chemometric analyses of far-field Raman spectra accurately classified their internal structures from their vibrational signatures. These classifications provide direct insight into the elemental arrangement of the alloy as well as an independent prediction of fluorescence quantum yield. This nondestructive, rapid approach can be broadly applied to greatly enhance our capacity to measure, predict and monitor multicomponent nanomaterials for precise tuning of their structures and properties.
Naturally Occurring Water Pollutants (2011)

Water quality is determined in part by the characteristics and concentrations of naturally occurring constituents. Many of these constituents are considered pollutants because they can harm the local ecology, aquatic organisms, or the people and other animals that use the water. For the purpose of this chapter, a naturally occurringwater pollutant (hereafter sometimes referred to as a “natural pollutant”) is defined as an element, amolecule, a compound, or an organism that is pathogenic to humans and is found in groundwater, surface water, in aerosols generated from these waters, or in the food chain influenced by these waters. For a natural pollutant to be pathogenic (i.e., capable of producing disease in humans or other animals), there must be a route whereby potential victims can be exposed (e.g., ingestion, inhalation, or dermal contact). In addition, the individual must be susceptible to the specific disease and receive a dose of the pollutant that is sufficiently infectious or toxic to produce the disease. Natural pollutants accumulate in waters as a result of physical and chemical processes (e.g., leaching from bedrock), biological processes (e.g., release of metabolic by-products or exuberant growth of harmful algae), or deposition from the air. Natural pollutants can also be present in waters as the result of human activities or manmade systems that expedite the transfer of contaminated water from one place to another (e.g., agricultural waterways). The contaminants listed in this chapter range from elements to complex compounds, from single-celled yeasts to multicellular helminthes, and they have been documented or are implicated in diseases in humans and aquatic flora and fauna. In this chapter, we discuss direct exposures to these contaminants through drinking water and indirect exposures though the contaminants’ accumulation in foods, particularly seafood. We also discuss the additional complexity of addressing environmental reality—exposure to mixtures. Finally, we discuss how physical forcers, such as changes in climate and land use, might mitigate or exacerbate the public health impacts of these contaminants.
Identification of a Small TAF Complex and Its Role in the Assembly of TAF-Containing Complexes (2007)

TFIID plays a role in nucleating RNA polymerase II preinitiation complex assembly on protein-coding genes. TFIID is a multisubunit complex comprised of the TATA box binding protein (TBP) and 14 TBP-associated factors (TAFs). Another class of multiprotein transcriptional regulatory complexes having histone acetyl transferase (HAT) activity, and containing TAFs, includes TFTC, STAGA and the PCAF/GCN5 complex. Looking for as yet undiscovered subunits by a proteomic approach, we had identified TAF8 and SPT7L in human TFTC preparations. Subsequently, however, we demonstrated that TAF8 was not a stable component of TFTC, but that it is present in a small TAF complex (SMAT), containing TAF8, TAF10 and SPT7L, that co-purified with TFTC. Thus, TAF8 is a subunit of both TFIID and SMAT. The latter has to be involved in a pathway of complex formation distinct from the other known TAF complexes, since these three histone fold (HF)-containing proteins (TAF8, TAF10 and SPT7L) can never be found together either in TFIID or in STAGA/TFTC HAT complexes. Here we show that TAF8 is absolutely necessary for the integration of TAF10 in a higher order TFIID core complex containing seven TAFs. TAF8 forms a heterodimer with TAF10 through its HF and proline rich domains, and also interacts with SPT7L through its C-terminal region, and the three proteins form a complex in vitro and in vivo. Thus, the TAF8-TAF10 and TAF10-SPT7L HF pairs, and also the SMAT complex, seem to be important regulators of the composition of different TFIID and/or STAGA/TFTC complexes in the nucleus and consequently may play a role in gene regulation.
Using Short Dietary Questions to Develop Indicators of Dietary Behaviour for Use in Surveys Exploring Attitudinal and/or Behavioural Aspects of Dietary Choices (2015)

For countries where nutrition surveys are infrequent, there is a need to have some measure of healthful eating to plan and evaluate interventions. This study shows how it is possible to develop healthful eating indicators based on dietary guidelines from a cross sectional population survey. Adults 18 to 64 years answered questions about the type and amount of foods eaten the previous day, including fruit, vegetables, cereals, dairy, fish or meat and fluids. Scores were based on serves and types of food according to an established method. Factor analysis indicated two factors, confirmed by structural equation modeling: a recommended food healthful eating indicator (RF_HEI) and a discretionary food healthful eating indicator (DF_HEI). Both yield mean scores similar to an established dietary index validated against nutrient intake. Significant associations for the RF_HEI were education, income, ability to save, and attitude toward diet; and for the DF_HEI, gender, not living alone, living in a socially disadvantaged area, and attitude toward diet. The results confirm that short dietary questions can be used to develop healthful eating indicators against dietary recommendations. This will enable the exploration of dietary behaviours for "at risk" groups, such as those with excess weight, leading to more relevant interventions for populations.
Package Order 001/4/45/12 - Traffic Officer Vehicle Conspicuity (2013)

The United Kingdom Highways Agency’s (HA) Traffic Officer Service officers often toil in high-risk situations, managing incidents on the HA’s trunk road network and motorways. A crucial part of their equipment for traffic incident management is their clearly-marked vehicles. This project attempted to ascertain whether parking the vehicle in parallel or fend off positions, and the utilization of amber or red and amber beacons, impacted the behavior of drivers coming upon the incident.
ChemInform Abstract: KINETISCHE UNTERSUCHUNGEN DER RK. VON H(4)‐1,2,3,6‐C8H12FE(CO)3 MIT TERT. PHOSPHINEN UND PHOSPHITEN (1973)

Abstract Die Verbindung (I) reagiert leicht mit Donorliganden (II) (Kohlenmonoxid, tert. Phosphine bzw. Phosphite) zum trans‐annularen Keton (V).
Molecular Dynamics as a Mathematical Mapping. II. Partial Derivatives in the Microcanonical Ensemble (2001)

Abstract Performing molecular dynamics in a fully continuous and differentiable framework can be viewed as a deterministic mathematical mapping between, on one side, the force field parameters that describe the potential energy interactions and input macroscopic conditions, and, on the other, the calculated corresponding macroscopic properties of the bulk molecular system. Within this framework, it is possible to apply standard methods of variational calculus for the computation of the partial derivatives of the molecular dynamics mapping based on the integration of either the adjoint equations or the sensitivity equations of the classical Newtonian equations of motion. We present procedures for these computations in the standard microcanonical (N, V, E) ensemble, and compare the computational efficiency of the two approaches. The general formulations developed are applied to the specific example of bulk ethane fluid. With these procedures in place, it is now possible to compute the partial derivatives of any property determined by molecular dynamics with respect to any input property and any potential parameter. Moreover, these derivatives are computed to essentially the same level of numerical accuracy as the output properties themselves. Key Words: Molecular dynamicsPartial derivativesAdjoint equationsSensitivity equations
Characterization of anisotropic aggregate behavior under variable confinement conditions (1998)

Compared to the standard constant confining pressure (CCP) tests, the variable confining pressure (VCP) type repeated load triaxial tests better simulate in the laboratory the effects of moving wheel loads since in the pavement structure the confining stress acting is cyclic in nature. In this paper, the important effects of VCP conditions in triaxial testing are considered in establishing anisotropic aggregate moduli. The anisotropic stiffnesses are next characterized using nonlinear models.
Sequences and arrays with perfect periodic correlation (1988)

Properties and methods for synthesizing sequences with perfect periodic autocorrelation functions and good energy efficiency are discussed. The construction is extended to two-dimensional perfect arrays. The construction methods used are based mainly on a search in the frequency domain and on a multiplication theorem for periodic sequences and arrays.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
189. Bromination of triterpenoids of the oleanane and ursane series (1957)

O. P. Arya and R. C. Cookson, J. Chem. Soc., 1957, 972 DOI: 10.1039/JR9570000972