gebhart/patrepeval huggingface dataset:
Selection of Recombinant Antibodies From Antibody Gene Libraries (2007)

After the sequencing of the human genome is completed, the research focus shifts toward the analysis of gene products. The human genome encodes more than 30,000 genes. Owing to alternative mRNA splicing and posttranslational modifications, for example, glycosylation, phoshorylation, and so on, the number of different proteins of human proteome is supposed to easily exceed 90,000. Antibodies are key detection reagents for the "postgenomic" analysis of these proteins. Any systematic investigation of the human proteome requires high throughput methods for antibody generation. In vitro selection systems utilizing recombinant antibody repertoires offer this capability and capacity. The most commonly used contemporary in vitro selection system is antibody phage display, which has already yielded thousands of useful antibodies for therapy, research, and diagnostics. Herein, methods are described for the selection of recombinant antibody fragments from naive antibody gene libraries.
Final results of a phase III randomized study of concurrent weekly cisplatin-RT versus RT alone in locoregionally advanced nasopharyngeal carcinoma (NPC) (2004)

5523 Background/Objective: NPC is highly radiosensitive and chemosensitive. 3 cycles of 3-weekly chemotherapy concurrent with RT followed by 3 cycles of adjuvant chemotherapy has improved survival over RT alone in a previous randomized study. The regimen was associated with significant toxicities. This randomized phase III study compared concurrent weekly cisplatin-RT with RT alone in patients with locoregionally advanced NPC. Methods: Patients with Ho's N2 or N3 stage or N1 stage with nodal size ≥ 4 cm were randomized to receive cisplatin 40 mg/m2 weekly up to 8 weeks concurrently with RT (CRT) or RT alone. The primary endpoints are progression-free survival (PFS) and overall survival (OS). Results: 350 eligible patients were randomized. Baseline patient characteristics, treatment toxicities and PFS analysis at median follow up of 2.71 years have been published previously. At a median follow up of 5.5 years where 58 and 73 deaths were found out of 174 CRT and 176 RT patients respectively (95th and 5th percentiles ranging from 3.8 to 8.7 years respectively), the 5 year PFS was 62% for the CRT arm and 52% for the RT arm (p=0.0764 with a hazards ratio of 1.33 and a 95% C.I. 0.97 to 1.84). The 5 year OS was 72% for the CRT arm and 59% for the RT arm (p=0.0479) with a hazards ratio of 1.41 (95% C.I. 1.00 to 2.00). Using Cox regression analysis, male sex (p=0.0284), advanced Ho's T (p=0.0002) and advanced age (p=0.0019) had poorer prognoses. The treatment-by-covariate interaction effect was not significant under the Cox model (p=0.1122, 3 d.f.). The treatment effect on OS remains borderline significant in favor of CRT (p=0.0586, with hazards ratio of 1.40 with 95% C.I. 0.99 to 1.97) after adjusting for significant covariates. There were no treatment-related deaths. In the CRT arm, 4.6% of patients had grade 4 mucositis and 12.6% of patients had grade 3 leukopenia. Conclusion: Weekly cisplatin-RT is well tolerated in patients with advanced NPC in endemic areas and is associated with clinically significant improvement in PFS and OS. This regime can be offered as standard treatment in locoregionally advanced NPC. No significant financial relationships to disclose.
Antigen 85B peptidomic analysis allows species-specific mycobacterial identification (2018)

LC-MS/MS analysis of Ag85B peptides from trypsin-digested mycobacterial culture supernatants can rapidly detect and identify common mycobacteria responsible for most pulmonary infections caused by slow-growing mycobacteria, and has the potential to rapidly diagnose pulmonary infections caused by these mycobacteria through direct analysis of clinical specimens.
Lossless compression of multispectral image data (1994)

While spatial correlations are adequately exploited by standard lossless image compression techniques, little success has been attained in exploiting spectral correlations when dealing with multispectral image data. The authors present some new lossless image compression techniques that capture spectral correlations as well as spatial correlation in a simple and elegant manner. The schemes are based on the notion of a prediction tree, which defines a noncausal prediction model for an image. The authors present a backward adaptive technique and a forward adaptive technique. They then give a computationally efficient way of approximating the backward adaptive technique. The approximation gives good results and is extremely easy to compute. Simulation results show that for high spectral resolution images, significant savings can be made by using spectral correlations in addition to spatial correlations. Furthermore, the increase in complexity incurred in order to make these gains is minimal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Laboratory Study on Reduction of the Heat Island Effect of Asphalt Pavements (2009)

Heat islands are formed as a result of construction that replaces vegetation with absorptive surfaces. Air temperature rises as a result of formation of heat islands. One suggested method to reduce the emitted heat from asphalt pavement surfaces is to reduce the temperature of the surface by flowing a suitable fluid through the pavement. The heated fluid could then be used for different end applications. Laboratory experiments were carried out using compacted hot mix asphalt samples with quartzite and metagranodiorite aggregates. Pipes with different surface area were used to flow water through the samples, and the processes were modeled using finite element method. The results clearly show the feasibility of the proposed method, and indicate the beneficial effects of higher thermal conductivity of aggregates and larger surface area of pipes. Velocity and thermal profiles of water in the pipe inside asphalt pavement are analyzed, and the necessity of good contact between asphalt mix and fluid carrying pipe is illustrated.
Efficient and Secure Indirect-Address Service Discovery in Manet (2006)

Service discovery protocols address the problem of preliminary association or storage of services at specific service providers and, at a later stage, efficient lookup for providers responsible for demanded client's services, in mobile ad hoc networks (MANET) used for military applications, both the efficiency of service discovery- protocols and the security of such protocols against adversaries are of crucial importance for the success of, say, battlefield operations. In this paper we consider a recently proposed lookup protocol that satisfies interesting efficiency properties by using an approach reminiscent of indirect-address storage techniques, and thus significantly different from other well-known flooding-type approaches. We observe that this protocol can be adapted to obtain a service discovery protocol in MANET. Specifically, we build an index system that matches services to their correspondent service agents; then servers register themselves to selected agents, and clients can efficiently retrieve the service information from the specific service agents. We then investigate the problem of securing the proposed protocol against Byzantine adversaries. Our main result is the design and analysis of a both efficient and secure service discovery protocol based on indirect-address techniques.
ChemInform Abstract: STERIC COURSE OF THE CONVERSION OF ENAMINES FROM OPEN‐CHAIN ALDEHYDES AND KETONES WITH NITRO OLEFINS TO 2,3‐DISUBSTITUTED 4‐NITRO KETONES (1985)

Abstract Es wird gezeigt, daß die durch die Titelreaktion der Komponenten (I) und (II) gebildeten Produkte die angegebenen relativen Konfigurationen aufweisen [die Konfiguration von (IIIa) insbesondere wird durch chemische Korrelationsreaktionen gesichert].
Respiratory muscle oxygen consumption estimated by the diaphragm pressure-time index (1984)

The O2 consumption of the respiratory muscles (VO2resp), work of breathing, and the time integral of the transdiaphragmatic pressure (TTdi) were measured in four normal subjects breathing against inspiratory resistance. A total of 39 runs were performed at mean tidal transdiaphragmatic pressures (Pdi) ranging from 15 to 53 cmH2O, respiratory frequencies from 3.5 to 22 breaths/min, and inspiratory time durations (TI) from 32 to 76% of the total breath duration. Each run was maintained from 8 to 17 min and the above parameters were kept constant by the subject via visual feedback of Pdi and TI with an oscilloscope. Most of the runs (36 of 39) were performed at TTdi values below those known to produce respiratory muscle fatigue. We found a strong linear correlation between the VO2resp and the TTdi (r = 0.74, P less than 0.001) and a weaker correlation between VO2resp and W (r = 0.31, P less than 0.05). These data suggest that TTdi is a good estimator of VO2resp over a wide range of respiratory patterns during inspiratory resistance breathing. The high variability seen in respiratory muscle efficiency during resistive breathing may be due to W not being a good indicator of the energy consumed by the respiratory muscles.
Impact de la fiabilité de MOEMS sur les performances simulées des brasseurs optiques (2008)

National audience
A framework for the power consumption and ber performance of ultra-low power wireles swearable healthcare and human locomotion tracking systems via UWB radios (2009)

In this paper, we propose a framework for the study of power consumption and bit error rate (BER) performance of non-coherent impulse radio ultra wideband (IR-UWB) correlation receivers in the IEEE 802.15.3a channel. Using this framework, transmitted reference (TR) and energy detection (ED) correlation receivers are studied and compared. The receivers are assumed to operate in the 3.1-5 GHz band targeting low-power consumption, where the correlation is performed in the analog domain. The BER performance is based on the channel averaged signal-to-noise ratio (SNR). Moreover, the framework addresses and compares different power consumption and performance parameters, namely the signal bandwidth, integration window, number of pulses per bit, and analog delay-lines. Then, we use the proposed framework for studying the fundamental design components of a wireless wearable human locomotion tracking and health-monitoring system based on UWB sensors. Ultimately, this system should provide high accuracy while consuming ultralow power. The study includes the link and power budgets of the system under investigation in addition to simulation results for the knee velocity. The accuracy provided by this system outperforms the accuracy of the current commercially available systems while preserving ultra-low power consumption.
Growth Kinetics of Intergranular Allotriomorph Ferrite in V-containing Steel (1998)

Growth kinetics of intergranular ferrite in a V-N steel has been investigated from the measurement of isothermal transformation kinetics. When compared with a V-C steel, the start of intergranular ferrite transformation starts earlier on isothermal transformation in the V-N steel, whereas its growth is retarded. The growth rates of the intergranular ferrite are under the parabolic rate rule for both steels with a smaller rate constant for the V-N steel. When the rate constants are ascribed to the supersaturation of carbon at the ferrite/austenite interface, the carbon concentrations are estimated to be 0.29 and 0.35 mass% for the V-N and V-C steels, respectively. Johnson-Mehl-Avrami plot of the transformation kinetics indicates that the ferrite nucleation rate is larger for the V-N steel. It is discussed that the precipitation of intragranular ferrite in the V-N steel is facilitated owing to the retardation of the intergranular ferrite growth in the steel.
Supra-threshold control of peripheral LOD (2004)

Level of detail (LOD) is widely used to control visual feedback in interactive applications. LOD control is typically based on perception at threshold -- the conditions in which a stimulus first becomes perceivable. Yet most LOD manipulations are quite perceivable and occur well above threshold. Moreover, research shows that supra-threshold perception differs drastically from perception at threshold. In that case, should supra-threshold LOD control also differ from LOD control at threshold?In two experiments, we examine supra-threshold LOD control in the visual periphery and find that indeed, it should differ drastically from LOD control at threshold. Specifically, we find that LOD must support a task-dependent level of reliable perceptibility. Above that level, perceptibility of LOD control manipulations should be minimized, and detail contrast is a better predictor of perceptibility than detail size. Below that level, perceptibility must be maximized, and LOD should be improved as eccentricity rises or contrast drops. This directly contradicts prevailing threshold-based LOD control schemes, and strongly suggests a reexamination of LOD control for foveal display.
Dynamic Operation of a Nonlinear Waveguide for Optical Logic (1988)

Experimental study of an annealed Silicon-on-Sapphire nonlinear waveguide in the pulsed regime can show two consecutive subnanosecond switchings allowing its operation as an optical logic gate.
Chloride in natural waters: An environmental application of a potentiometric titration (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChloride in natural waters: An environmental application of a potentiometric titrationGeorge Lisensky and Kelly. Reynolds Cite this: J. Chem. Educ. 1991, 68, 4, 334Publication Date (Print):April 1, 1991Publication History Received3 August 2009Published online1 April 1991Published inissue 1 April 1991https://doi.org/10.1021/ed068p334RIGHTS & PERMISSIONSArticle Views1525Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Determination of Lignin in Non-Wood Plant Fiber Sources (1971)

Lignin contents of representative non-wood plants were determined by a 2-hr treatment at 5°C with 80 % sulfuric acid. Representative genera were selected to give data on stem fibers, leaf or hard fibers, and forages. The results were compared with those of a 16-hr, 72 % sulfuric acid procedure from the literature. Relative standard deviations for the materials by the two methods are comparable; i.e., ±2.41-3.48% and ±2.74-3.60% with 80 and 72% acid, respectively. Analysis of variance showed significant differences between the materials at the 99 % confidence level. However, at the 95 % confidence level, differences due to method were found only for hard-fibered leaf material. The considerable time savings afforded by the 2-hr (5°C), 80% sulfuric acid method is desirable. The 80 % sulfuric acid method has been adopted in our laboratory as the one of choice for determining lignin in fibrous non-wood plants.
Tailored SERS substrates obtained with cathodic arc plasma ion implantation of gold nanoparticles into a polymer matrix (2011)

This manuscript reports on the fabrication of plasmonic substrates using cathodic arc plasma ion implantation, in addition to their performance as SERS substrates. The technique allows for the incorporation of a wide layer of metallic nanoparticles into a polymer matrix, such as PMMA. The ability to pattern different structures using the PMMA matrix is one of the main advantages of the fabrication method. This opens up new possibilities for obtaining tailored substrates with enhanced performance for SERS and other surface-enhanced spectroscopies, as well as for exploring the basic physics of patterned metal nanostructures. The architecture of the SERS-active substrate was varied using three adsorption strategies for incorporating a laser dye (rhodamine): alongside the nanoparticles into the polymer matrix, during the polymer cure and within nanoholes lithographed on the polymer. As a proof-of-concept, we obtained the SERS spectra of rhodamine for the three types of substrates. The hypothesis of incorporation of rhodamine molecules into the polymer matrix during the cathodic arc plasma ion implantation was supported by FDTD (Finite-Difference Time-Domain) simulations. In the case of arrays of nanoholes, rhodamine molecules could be adsorbed directly on the gold surface, then yielding a well-resolved SERS spectrum for a small amount of analyte owing to the short-range interactions and the large longitudinal field component inside the nanoholes. The results shown here demonstrate that the approach based on ion implantation can be adapted to produce reproducible tailored substrates for SERS and other surface-enhanced spectroscopies.
Lifetime of an Adsorbate-Substrate Vibration: H on Si(111). (1990)

Among the recent developments in surface science is the study of dynamical processes and energy transfers. It is thought in particular that lifetimes of adsorbate vibrations should have an important effect on the chemistry of adsorbates on surfaces.
Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model. (1988)

Suppression of cellular immunity and increased susceptibility to sepsis frequently accompany thermal injury. However, a convincing association between the two has been difficult to establish in human beings. Therefore we chose to investigate the relationship of impaired cell-mediated immunity with susceptibility to sepsis in an animal model. We studied the response to phytohemagglutinin (PHA) and interleukin-2 (IL-2) production by splenocytes from mice subjected to a standard 25% scald burn and killed at intervals of 3, 5, 7, 10, 14, and 25 days after thermal injury. Burned mice were compared in all instances to sham-burn animals (i.e., animals that had been anesthetized and shaved but not burned). We also studied mortality after cecal ligation and puncture (CLP), as a septic challenge, in burned and control animals at the same postburn intervals. We found maximal suppression (50% to 55%) of the PHA response at 10 to 14 days after injury and maximum suppression (68%) of IL-2 production at 7 days. Both of these parameters returned to normal by postinjury day 28. Mortality after CLP increased gradually from control levels after thermal injury up to a maximum of 88% on postburn day 10 and also returned to control levels after 28 days after burn. Significant correlations were found between mortality after CLP in the postburn period and suppression of the PHA response, on the one hand, and the suppression of IL-2 production, on the other (r = 0.89 and 0.91, respectively; p less than 0.05). This result implies a causal relationship between impaired cell-mediated immunity and susceptibility to sepsis after burn injury.
Design Principles of an Open Agent Architecture for a Web-based Learning Community (2001)

A Web-based learning community involves much more than putting learning materials into a Web site. It can be seen as a complex virtual organization involved with people, facilities, and cyber-environment. Tremendous work and manpower for maintaining, upgrading, and managing facilities and the cyber-environment are required. There is presented an inevitable choice to use various agents to assist or replace people to a certain extent for the work in a virtual learning community. There is a strong need for the development of the designated architecture for integrating and using various agents. This research focuses on developing an open agent architecture that can easily integrate developed agents into a learning system and flexibly modify the agents with permission. This paper describes the design ideas of such desired architecture, demonstrates how the architecture system works, and explains three agents--the scheduling agent, the friend-making agent, and the Web-course management agent--in a Web-based learning system called University2l. (Contains 10 references.) (MES) Reproductions supplied by EDRS are the best that can be made from the original document. PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY
765. The polysaccharides of baker's yeast. Part V. A further study of the mannan (1961)

S. Peat, J. R. Turvey and D. Doyle, J. Chem. Soc., 1961, 3918 DOI: 10.1039/JR9610003918
Finite element calculation of creep crack initiation on an IP-turbine rotor using the C*-parameter (1998)

Creep crack initiation results from a heat resistant turbine rotor steel of type 1%Cr-1%Mo-0.6%Ni-0.3%V are described by the parameter C*, which is calculated on the basis of an inelastic finite element analysis. The application of these results for the calculation of creep crack initiation of an assumed internal defect in the center of an IP rotor is discussed. The time to creep crack initiation estimated on the basis of the C*-concept is compared with a predicition by means of the analytical two-criteria- concept.
Esbozo de una poética de la novela corta en la obra de Mario Bellatin (2018)

Al final de la decada del cincuenta, un laboratorio aleman crea una nueva medicina para los malestares de la mujer embarazada. Esta nueva pildora pretendia aliviar la nausea y la falta de sueno en la paciente, en principio. De manera que, tan pronto como la farmaceutica Chemie Grunenthal –famosa tambien por ser la primera en introducir la penicilina en Alemania– lanzo al mercado el comprimido bajo el slogan “tan inocuo como un caramelo”, una gran parte de la poblacion femenina gestante incorporo a su dieta diaria la funesta Talidomida...
N-phthaloylation of chloro- and hydroxy-2-amino-acids (1973)

Because of displacement and amide–hydroxy neighbouring group reactions, 2-amino-acids bearing 4-substituents, (halogen, hydroxy) are difficult to acylate. New synthetic techniques designed to minimise these side reactions and to allow N-phthaloylation of chloro- and hydroxy-amino-acids are discussed. N-Phthaloylation of 4-chloro-and 4-hydroxylysines in aprotic solvents has been found to occur in high yield, and preferential attack at the 6-amino-function of these 4-substituted lysines has been observed.
Anomalous wave transport in one-dimensional systems with Levy disorder (2018)

We use random matrix theory to study the statistics of wave transport in one-dimensional random media with Levy disorder, in which waves perform Levy flights.