gebhart/patrepeval huggingface dataset:
Substituent effects on OH bond strength and hyperfine properties of phenol, as model for modified tyrosyl radicals in proteins (2000)

Density functional theory is used to investigate the effects of a variety of substituents (CH3, OH, OCH3, SH, SCH3, NH2, NMe2, NO2, F, Cl, CN, and imidazole) on the phenol OH bond dissociation energy (BDE) and phenoxyl radical hyperfine properties. Substitutions are made at the ortho position to model modified tyrosine residues found in enzymes. The calculations show that besides the electronic effects of the substituents, intramolecular hydrogen bonds between OH and the substituents will contribute considerably to stabilize the parent species. Substituent effects on anisole OMe bond strengths can thus not correctly describe the effects on ortho-substituted phenol OH bond strengths, as previously proposed. This fact is supported by a series of calculations on o-substituted anisoles. The odd-alternant spin pattern of the phenoxyl radical is conserved for most of the substitutions. In particular, it is predicted that the cysteine crosslink to tyrosine, present in the radical enzyme galactose oxidase, and the histidine crosslink, present in cytochrome-c oxidase, will only have minor effects on the BDE and the radical hyperfine coupling constants and spin distribution of the tyrosyl radical. © 2000 John Wiley & Sons, Inc. Int J Quant Chem 76: 714–723, 2000
Web-pages sojourn times in high speed networks (2005)

Processor sharing (PS) queuing systems have been historically applied for the estimation of file Sojourn times. We present a model for Web-pages sojourn times at the session-layer by incorporating the time spent by TCP in its slow start and congestion avoidance phases. The model is a function of not only the residual capacity of the bottleneck link but also of the packet loss probability and round trip time (RTT) delay. We show that the model effectively captures the Web-pages sojourn times in high speed networks.
Mechanism of fibroblast inflammatory responses to Pseudomonas aeruginosa elastase (2014)

Receptor tyrosine kinases, including the epidermal growth factor receptors (EGFR), are able to activate the mitogen-activated protein kinases (MAPK) via several adaptor proteins and protein kinases such as Raf. EGFR can be activated by a variety of extracellular stimuli including neutrophil elastase, but we are aware of no report as to whether Pseudomonas aeruginosa produced elastase (PE) could elicit such signalling through EGFR activation. We sought to test the inference that PE modulates inflammatory responses in human lung fibroblasts and that the process occurs by activation of the EGFR/MAPK pathways. We utilized IL-8 cytokine expression as a pathway-specific end point measure of the fibroblast inflammatory response to PE. Western blot analysis was performed to detect phosphorylation of EGFR and signal transduction intermediates. Northern blot, real-time PCR, and ELISA methods were utilized to determine cytokine gene expression levels. We found that PE induces phosphorylation of the EGFR and the extracellular signal-regulated proteins (ERK1/2) of the MAPK pathway, and nuclear translocation of NF-κB. Furthermore, enzymically active PE enhances IL-8 mRNA and protein secretion. Pretreatment of the cells with specific inhibitors of EGFR, MAPK kinase and NF-κB markedly attenuated the PE-induced signal proteins phosphorylation and IL-8 gene expression and protein secretion. Collectively, the data show that PE produced by Pseudomonas aeruginosa can modulate lung inflammation by exploiting the EGFR/ERK signalling cascades and enhancing IL-8 production in the lungs via NF-κB activation.
Non-Negative Spherical Deconvolution for Fiber Orientation Distribution Estimation (2013)

International audience
Caracterización y estudio de los morteros y materiales pétreos, en las ruinas de la ciudad de Pompeya (2007)

Key Word: Archaeology, architecture, Pompeii, factories, materials. In this work Isle carries out a study of the “Regio VII, Insula 3” of Pompeii (Italy), under of a Project subsidized by the Spanish Department of Culture and the university of Alicante. Studies have been realized on the characteristics tipologicas of the isle, of the buildings and of his factories. Also a raising and graphical study of the fronts and the tipologias of factories, studying the materials that form them. In the stony materials the Calcareous of the Sarno has been identified, Nocera tufa, cruma, yellow Marble, and artificial ones as the Latericio and Cocciopesto. In the mortars they have been of sand and lime: harenatum, that of white marble and lime: Opus albarium and the of lime with ceramic: Opus signinum. In the characterization different technologies: diffraction of beams X, S.E.M., thin sheet and chamber of infrared. This communication reflects the results of the studies before related.
Characterization of zinc oxide nanoparticle (nZnO) alginate beads in reducing gaseous emission from swine manure (2016)

Hydrogen sulfide (H<sub>2</sub>S) and greenhouse gases' emission from livestock production facilities are of concern to human welfare and the environment. Application of nanoparticles (NPs) has emerged as a potential option for minimizing these gaseous emissions. Application of bare NPs, however, could have an adverse effect on plants, soil, human health, and the environment. To minimize NPs' exposure to the environment by recovering them, NPs were entrapped in polymeric beads for treating livestock manure. The objectives of the research were to understand the mechanism of gaseous reduction in swine manure treated for 33 days with zinc oxide nanoparticles (nZnO) or nZnO-entrapped alginate (alginate-nZnO) beads by different characterization techniques. Headspace gases from treated manure flasks were collected in 2-6-day intervals during the experimental period and were analyzed for methane (CH<sub>4</sub>), carbon dioxide (CO<sub>2</sub>), and H<sub>2</sub>S concentrations. The microbial analysis of manure was carried out using bacterial plate counts and Real-Time Polymerase Chain Reaction methods. Morphology and chemical composition of alginate-nZnO beads were analyzed by Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), and X-ray Photoelectron Spectroscopy (XPS). Alginate-nZnO beads or bare nZnO proved to be an effective NP in reducing H<sub>2</sub>S (up to 99%), CH<sub>4</sub> (49-72%), and CO<sub>2</sub> (46-62%) from manure stored under anaerobic conditions and these reductions are likely due to the microbial inhibitory effect from nZnO, as well as chemical conversion. Both SEM-EDS and XPS analysis confirmed the presence of zinc sulfide (ZnS) in the beads, which is likely formed by reacting nZnO with H<sub>2</sub>S.
A generalized Poisson based model for defect spatial distribution in WSI (2002)

Discusses the use of the modified generalized Poisson binomial limit in modeling defect spatial distribution in WSI (wafer scale integration) and large-area VLSI chips. This model demonstrates the usefulness of generalized Poisson distributions for effectively taking into account the issues of the distribution of clusters and cluster sizes. The strength of the proposed model lies in its simplicity and its close adherence to the forms of defect patterns on a wafer. The model shows excellent fits to the data from simulated wafer maps with high clustering of defects. It also exhibits good fits to data from wafers with small-area, highly dispersed clusters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hemoglobin Oxygen Affinity and the Design of Red Cell Substitutes (1997)

A model is described for evaluating a number of properties of cell-free oxygen carriers with regard to their potential to produce autoregulatory vasoactivity in arterioles. The model is based on the Krogh cylinder, an idealized segment of vessel. It is unique because it “maps” the regulatory region of the arterioles - the precapillary segment which senses O2 supply and controls local vascular tone. Through a detailed analysis of the shape and position of oxygen equilibrium curves, the amount of O2 delivered to this sensitive region is analyzed as a function of diffusion, hemoglobin concentration, and P50. The results support the emerging general theory that cell-free oxygen carriers may overcome a diffusive limitation to O2 delivery to tissue, resulting in an over-supply of O2 to regulatory arterioles, leading to local vasoactivity. The model predicts that two potential strategies to overcome this limitation are to lower P50 and to lower the oxygen carrying capacity of the blood.
Growth of Breath Figures on Fluid Surfaces (1988)

Breath figures are the patterns formed when droplets condense on surfaces. We describe studies of such patterns that result when water condenses on the surface of a viscous oil. The average droplete diameter ⟨D⟩ exhibits two regimes of power law growth; at early times ⟨D⟩ ∼ t0.3 and at late times ⟨D⟩ ∼ t. The crossover can be understood as a transition from single-droplet growth to growth dominated by coalescence. A comparison with corresponding growth on solid substrates is performed.
Design and simulation of a thermal flow sensor for gravity-driven microfluidic applications (2016)

Gravity-driven flow is an attractive approach to develop simpler microfluidic systems. Because clogged microchannels could easily lead to fatal operational failures, it is crucial to monitor flow rate in these systems. Therefore, we propose here for the first time a numerical model that combines a calorimetric flow sensor and a gravity-driven system. With the validated model, we studied the flow behavior in a gravity-driven system. Furthermore, we were able to improve the sensitivity of the measurement based on simulation results. This demonstrates, how the model could be used as an effective optimization tool in the gravity-driven system including calorimetric flow measurement.
Advanced light microscopy techniques (2012)

This article summarizes the basic principles of light microscopy, with examples of applications in biomedicine that illustrate the capabilities of the technique. Handbook of instrumental techniques from CCiTUB Advanced Light Microscopy Techniques 1 BT.4
Clinicopathological Case Series of Four Patients with Inherited Macular Disease (2009)

RPE transplantation provides a unique opportunity to gain insight into retinal disorders by enabling phenotypic correlation with the immunohistopathology of retinal tissue collected during surgery.
Market-Driven Innovation (2008)

A new method for starting the iterative innovation process from the market side based on a sociological trend has been developed. It eliminates the traditional difference between the innovators and the sociological group that carries this trend, which can only be achieved by combining real-world innovation with innovation education. The method for market need discovery is presented as a step-by-step process with detailed reasoning, followed by a real-world example that details the outcomes at every step along the way. The example concludes with a detailed description of the outcome after the first innovation iteration cycle. The richness of the resulting concept demonstrates that an innovation process can be successfully started from the market side via the proposed method.
A Differential Equation for Modeling Nesterovâ€™s Accelerated Gradient Method: Theory and Insights (2014)

We derive a second-order ordinary differential equation (ODE), which is the limit of Nesterov's accelerated gradient method. This ODE exhibits approximate equivalence to Nesterov's scheme and thus can serve as a tool for analysis. We show that the continuous time ODE allows for a better understanding of Nesterov's scheme. As a byproduct, we obtain a family of schemes with similar convergence rates. The ODE interpretation also suggests restarting Nesterov's scheme leading to an algorithm, which can be rigorously proven to converge at a linear rate whenever the objective is strongly convex.
Role of Cyclooxygenase-2 in Exacerbation of Allergen-Induced Airway Remodeling by Multiwalled Carbon Nanotubes (2013)

The emergence of nanotechnology has produced a multitude of engineered nanomaterials such as carbon nanotubes (CNTs), and concerns have been raised about their effects on human health, especially for susceptible populations such as individuals with asthma. Multiwalled CNTs (MWCNTs) have been shown to exacerbate ovalbumin (OVA)-induced airway remodeling in mice. Moreover, cyclooxygenase-2 (COX-2) has been described as a protective factor in asthma. We postulated that COX-2-deficient (COX-2(-/-)) mice would be susceptible to MWCNT-induced exacerbations of allergen-induced airway remodeling, including airway inflammation, fibrosis, and mucus-cell metaplasia (i.e., the formation of goblet cells). Wild-type (WT) or COX-2(-/-) mice were sensitized to OVA to induce allergic airway inflammation before a single dose of MWCNTs (4 mg/kg) delivered to the lungs by oropharyngeal aspiration. MWCNTs significantly increased OVA-induced lung inflammation and mucus-cell metaplasia in COX-2(-/-) mice compared with WT mice. However, airway fibrosis after exposure to allergen and MWCNTs was no different between WT and COX-2(-/-) mice. Concentrations of certain prostanoids (prostaglandin D2 and thromboxane B2) were enhanced by OVA or MWCNTs in COX-2(-/-) mice. No differences in COX-1 mRNA concentrations were evident between WT and COX-2(-/-) mice treated with OVA and MWCNTs. Interestingly, MWCNTs significantly enhanced allergen-induced cytokines involved in Th2 (IL-13 and IL-5), Th1 (CXCL10), and Th17 (IL-17A) inflammatory responses in COX-2(-/-) mice, but not in WT mice. We conclude that exacerbations of allergen-induced airway inflammation and mucus-cell metaplasia by MWCNTs are enhanced by deficiencies in COX-2, and are associated with the activation of a mixed Th1/Th2/Th17 immune response.
On continuous time differentiation observers (1999)

The so-called high gain observers are alternatives to the longstanding problem of estimating the state (or parameters) of general nonlinear systems. They consist of a linear infinite impulse response filter, and are made to work mainly by cranking their gain so as to overcome the adverse nonlinearities of the plant being observed. Their main point is the simplicity of the design. But they suffer from a structural drawback: by cranking the gain in order to reduce the residual estimation error, at the same time, the user is increasing the overshoots of the estimates in presence of singularities. Singularity refers here to initial conditions and measurements uncertainties. Assuming that measurement uncertainties may be adequately filtered out it remains that the inherent peaking behavior cannot be remedied without a redesign of the observer gain. In this communication we emphasize the fact that reduced peaking feature may be obtained merely by using a full dynamic gain. The gain is obtained by solving a differential equation either offline or online. The observer thus obtained is a continuous time counterpart of numerical differentiation observers which motivates the title of this communication. The observer is used to simulate the online estimation of the state variable of an academic single link flexible joint robot which involves differentiation of the measurements up to 3 times.
Multipolar analysis of second-harmonic radiation from gold nanoparticles (2008)

We present a multipolar tensor analysis of second-harmonic radiation from arrays of noncentrosymmetric L-shaped gold nanoparticles. Our approach is based on the fundamental differences in the radiative properties of electric dipoles and higher multipoles, which give rise to differences in the nonlinear response tensors for the reflected and transmitted second-harmonic signals. The results are analyzed by dividing the tensors into symmetric (dipolar) and antisymmetric (higher multipolar) parts between the two directions. The nonlinear response is found to be dominated by a tensor component, not resolved earlier [Phys. Rev. Lett. 98, 167403 (2007)], which is associated with chiral symmetry breaking of the sample and which also contains a strong multipolar contribution. The results are explained by a phenomenological model where asymmetrically-distributed defects on opposite sides of the particles give rise to dipolar and quadrupolar second-harmonic emission.
Analytic banded approximation for the discretized free propagator (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalytic banded approximation for the discretized free propagatorDavid K. Hoffman, Naresh Nayar, Omar A. Sharafeddin, and D. J. KouriCite this: J. Phys. Chem. 1991, 95, 21, 8299–8305Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/j100174a052https://doi.org/10.1021/j100174a052research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations135LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effectiveness of Growth Hormone To Prevent the Alterations Produced by 6-Methylprednisolone (Medrol) on the Growing Bone in Rats (1963)

Growth hormone of bovine and sheep (ovine) origin administered to growing rats receiving 6-methylprednisolone (Medrol) was found to prevent the deleterious effects of this steroid on bone growth and structure, but did not improve the change in body weight.
Quantitative phase study of the dynamic cellular response in femtosecond laser photoporation (2010)

We use Digital Holographic Microscopy to study dynamic responses of live cells to femtosecond laser cellular membrane photoporation. Temporal and spatial characteristics of morphological changes as well as dry mass variation are analyzed and compared with conventional fluorescent assays for viability and photoporation efficiency. With the latter, the results provide a new insight into the efficiency and toxicity of this novel optical method of drug delivery. In addition, quantitative phase maps reveal photoporation related sub-cellular dynamics of cytoplasmic vesicles.
Dual-Polarized mm-Wave Antenna Solution for Mobile Phone (2020)

This article describes a novel dual-polarized mm-wave antenna for mobile phone devices. The mm-wave antenna module consists of a 4-layer PCB, an extra metallic piece acting as a reflector, and four metallic pins. The four metallic pins are placed on the top layer of the PCB acting as an array of vertically polarized monopoles. On the bottom layer an array of horizontally polarized dipoles are fed using microstrip lines. The two middle layers act as ground. Simulations show very good performance in the 27 to 29.5GHz range. In this frequency range, the horizontally and vertically polarized arrays provide better than –1.5dB efficiency, and higher than 11.5dBi realized gain. Also, the reflection coefficient is mostly below –10dB in the 27 to 29.5GHz range for each individual antenna element. Beam-steering is possible up to ± 35° for both polarizations with a scan loss below 3dB.
Epidemiological Spectrum and Current Treatment of Listeriosis (1991)

To reassess the epidemiology and treatment of listeriosis in the United States, we reviewed greater than 120 cases of listeriosis from four medical centers in three geographically separated cities: Los Angeles County-University of Southern California Medical Center (LAC-USCMC); Rush-Presbyterian-St. Luke's Hospital, Chicago; the University of Illinois Hospital, Chicago; and Vanderbilt University Hospital, Nashville, Tennessee. The epidemiological pattern at LAC-USCMC was relatively narrow; more than two-thirds of the cases occurred during the perinatal period. Cases at Vanderbilt University Hospital represented the opposite end of the spectrum; the majority of these occurred in nonpregnant, older adults who had received organ transplants. An intermediate pattern of cases was observed at the two medical centers in Chicago. Potential risk factors included pregnancy, neonatal status, organ transplantation, renal failure, malignancy, systemic lupus erythematosus, steroid therapy, and AIDS (two cases). Antimicrobial agents noted to be effective were, as expected, penicillin and ampicillin; the cephalosporins were ineffective. The mortality associated with listeriosis occurred mainly among premature infants and stillbirths delivered from infected pregnant women and was markedly less among neonates and adults.
Diagnosing growth in low-grade gliomas with and without longitudinal volume measurements: A retrospective observational study (2019)

The current practice of visual comparison of longitudinal MRI scans is associated with significant delays in detecting growth of low-grade gliomas. Our findings support the idea that physicians aided by CAD detect growth at significantly smaller volumes than physicians using visual comparison alone. This study does not answer the questions whether to treat or not and which treatment modality is optimal. Nonetheless, early growth detection sets the stage for future clinical studies that address these questions and whether early therapeutic interventions prolong survival and improve quality of life.
Balloon Bronchoplasty (2005)

Balloon bronchoplasty is a procedure central to practice of interventional bronchoscopy. It is easily used with both flexible and rigid bronchoscopy. It may used with fluoroscopic guidance over a guide wire or under direct vision. Balloon bronchoplasty is most commonly employed with high long term success for non-malignant causes of airway stenosis but it is also in malignant diseases. This technique is generally used in conjunction with other techniques (eg, electrocautery, stent deployment). The balloon should be silicone based and able to provide radial force. The inflation syringe must have a pressure gauge and knowledge of burst pressure must be observed. Complications are generally mucosal tears and minor bleeding but rupture of major airways and vascular structures have been reported.
Comments on ``Kinetic-Theory Approach to the Problem of Shock-Wave Structure in a Binary Mixture'' (1966)

First Page