gebhart/patrepeval huggingface dataset:
Elevated Expression of Heat Shock Factor (HSF) 2A Stimulates HSF1-induced Transcription during Stress (2003)

Heat shock factor 2 (HSF2) belongs to a family of structurally related transcription factors, which share the property of binding to heat shock elements in the promoters of hsp molecular chaperone genes. However, unlike HSF1, which is essential for hsp gene transcription, the cellular functions of HSF2 are not well known. Here we show that human HSF2, although an ineffective activator of the hsp70 promoter in vitro and in vivo in the absence of stress, participates in the activation of the hsp70 promoter by heat shock. HSF2 was not, however, activated by heat shock in cells deficient in functional HSF1, suggesting a requirement for HSF1 in HSF2-mediated transcriptional enhancement. In addition, HSF2 regulation involves differential activity of two isoforms, HSF2A and HSF2B, which arise from alternative splicing of a common hsf2 gene. Under basal conditions, both HSF2 isoforms are ineffective in activating the hsp70 transcription. However, heat shock differentially activates HSF2A in vivo. This phenomenon appears to be physiologically significant, as human myeloprogenitor cells differentiating along the erythroid lineage express HSF2A de novo and undergo a large increase in capacity to activate the hsp70 promoter. Our experiments further show that HSF1 is physically associated with HSF2 in the cell and that such binding is enhanced by heat shock. Our data suggest a mechanism involving the formation of heterocomplexes between HSF1 and HSF2 with enhanced activity to activate the hsp70 promoter when compared with HSF1 or HSF2 homotrimers.
Imprinting of hippocampal metabolism of choline by its availability during gestation: Implications for cholinergic neurotransmission (1998)

Choline supplementation during the second half of the gestational period in rats permanently improves visuospatial memory. Choline availability during this period also alters the turnover of choline and acetylcholine in the hippocampus in 3-4 week-old animals in a complex pattern consistent with the notion that cholinergic neurotransmission is enhanced by prenatal choline supplementation.
Thermal Measurements of Resonant Ultrasonic Surgical Horn (2015)

Temperatures at the distal end of the tip in ultrasonic surgical instruments are of interest because this is the applied part to a patient. It is difficult to directly measure these temperatures using contacting temperature sensors due to high vibration levels. Non-contact infrared (IR) thermography could be an important tool to experimentally determine the tip temperature. However, the low emissivity and polished cylindrical geometry of the tips complicate accurate IR thermography. In this study, we use Cr2O3 high emissivity paint to coat the tip for increased accuracy in IR measurements. Temperature measurements are consistent with heat generation models based on mechanical quality factor of about 5000 for the titanium tip material. It was found that no heat is generated at the tip distal end where strain is low. Air cooling by aspiration is effective at keeping tip distal end temperatures at near ambient levels even with heat transfer by conduction from warmer parts of the tip.
Conversion of External Fixation to Intramedullary Nailing for Fractures of the Shaft of the Femur in Multiply Injured Patients* (2000)

We concluded that immediate external fixation followed by early closed intramedullary nailing is a safe treatment method for fractures of the shaft of the femur in selected multiply injured patients.
Parse Selection on the Redwoods Corpus: 3rd Growth Results (2003)

This report details experimental results of using stochastic disambiguation models for parsing sentences from the Redwoods treebank (Oepen et al., 2002). The goals of this paper are two-fold: (i) to report accuracy results on the more highly ambiguous latest version of the treebank, as compared to already published results achieved by the same stochastic models on a previous version of the corpus, and (ii) to present some newly developed models using features from the HPSG signs, as well as the MRS dependency graphs.
Enhanced color conversion from colloidal CdSe/CdS dot/rods by vertical microcavities (2010)

Colloidal CdSe/CdS dot/rods exhibit efficient photoluminescence from the spherical CdSe dots at wavelengths well below the absorption edge of the rod material. This property makes dot/rods advantageous for color conversion applications, especially when they are embedded in optical microcavities to improve light extraction in forward direction. Here, surface emitting half-wavelength microcavities are demonstrated containing films of dot/rods as active material, exhibiting luminescence enhancement factors of up to 21 at the resonator wavelengths, whereas with conventional CdSe/ZnS core-shell nanocrystals only half of this value is obtained.
Reversible Rearrangements of Cu(II) Cage Complexes: Solvent and Anion Influences (2012)

The macrobicyclic mixed donor cage ligand AMME-N3S3sar (1-methyl-8-amino-3,13,16-trithia-6,10,19-triazabicyclo[6.6.6]eicosane) is capable of binding to Cu(II) as either a hexadentate (N3S3) or tetradentate (N2S2) ligand. The "Cu-in" (hexadentate)/"Cu-out" (tetradendate) equilibrium for the {Cu(AMME-N3S3sar)}(2+) units is strongly influenced by both solvent (DMSO, MeCN, and water) and halide ions (Br(-) and Cl(-)). We have established a crucial role of the solvent in these processes through the formation of intermediate solvato complexes, which are substituted by incoming halide ions triggering a final isomerization reaction. Surprisingly, for reactions carried out in the usually strongly coordinating solvent water, the completely encapsulated N3S3-bound "Cu-in" form is dominant. Furthermore, the small amounts of the "Cu-out" form present in equilibrated DMSO or MeCN solutions revert entirely to the "Cu-in" form in aqueous media, thus preventing reaction with halide anions which otherwise lead to partial or even complete decomposition of the complex. From the kinetic, electrochemical, and EPR results, the existence of an outer-sphere H-bonded network of water molecules interacting with the complex inhibits egress of the Cu(II) ion from the cage ligand. This is extremely relevant in view of outer sphere interactions present in strongly hydrogen bonding solvents and their effects on Cu(II) complexation.
Doxycycline Inhibits TGF-β1–Induced MMP-9 via Smad and MAPK Pathways in Human Corneal Epithelial Cells (2005)

These findings demonstrated that doxycycline inhibits TGF-beta1-induced MMP-9 production and activity, perhaps through the Smad and MAPK signaling pathways. These inhibitory effects may explain the reported efficacy of doxycycline in treating MMP-9-mediated ocular surface diseases.
Selective stimulation by mouse spleen cell conditioned medium of human eosinophil colony formation (1983)

Stimulation of unfractionated or nonadherent human marrow cells in agar culture by pokeweed-mitogen-stimulated BALB/c mouse spleen cell conditioned medium (SCM) led, in most cultures, to the exclusive formation of eosinophil colonies. The culture system exhibited linearity of eosinophil colony formation with varying numbers of cells cultured, and the absolute numbers and size of SCM-stimulated eosinophil colonies approximated those in cultures stimulated by human placental conditioned medium. The active factor in SCM for human eosinophil colony formation was not clearly separable from the factors stimulating granulocyte-macrophage and eosinophil colony formation by mouse marrow cells on ammonium sulfate and phenyl boronate chromatography, but was of larger size than the mouse-active factors and separable from them by phenyl sepharose chromatography. This selective culture system for eosinophil colony formation should be of value for studies on human eosinophil progenitor and maturing cell populations in a variety of disease states.
Adaptive transfer function concept for uncooled FLIR cameras (2004)

The adaptive transfer function concept analyzes the various factors contributing to the uncooled microbolometer FLIR camera performances, and describes a series of solutions to control in real time its transfer function for optimal performances. The paper describes the entire camera concept, elaborating in more details the following subjects: 1. The time domain filter used to improve the SNR and its control function, 2. The two dimensional filter used to remove the DC and the low frequencies components, 3. The supplementary filter used to reduce one over f law power noise on vertical direction, 4. The dynamic range compression and its control function.
<title>Optical Properties Of The Transmission Medium</title> (1978)

From a user viewpoint, the main optical properties of fiber waveguides are reviewed. Attention is given to the more subtle secondary effects that can influence the interpretation of attenuation, dispersion and numerical aperture data given in typical fiber or optical cable specification sheets. Based upon such optical specifications, systems designers can usually do only a first order estimate of how the fiber will perform in their particular application. Numerous references are given, emphasizing recent rather than original contributions. Secondly, the fiber is modelled as an interactive "black box" specified by a minimum number of phenomenological parameters. With transmitter and receiver characteristics held fixed, these parameters are independently varied to calculate their relative importance in systems performance. Multimode and monomode guides are considered, both at conventional and longer wavelengths. It is found that toward increasing transmission distances at lower information rates, the significant improvements in decreasing order of effectiveness are: longer wavelength operation, lower attenuation, higher launched power. At higher rates, mode mixing, an increase in multimode bandwidth and narrowing of source linewidth assume importance.
Bonding to sound vs caries-affected dentin using photo- and dual-cure adhesives. (2005)

This study aimed to evaluate the microtensile bond strength (microTBS) of photo- and dual-cure adhesives to sound and caries-affected dentin using total- and self-etch techniques. Human third molars with occlusal caries were prepared as previously described by Nakajima and others (1995). Dentin surfaces were bonded with Optibond Solo Plus (Kerr; photo-cure adhesive) or Optibond Solo Plus + Dual-cure activator (Kerr; dual-cure adhesive) with total- and self-etch technique. Clearfil AP-X (Kuraray) was used for composite buildups. Following storage in distilled water at 37 degrees C for 24 hours, the teeth were sectioned into 0.7-mm thick slices to obtain sound and caries-affected dentin slabs, then trimmed to form hour glass shapes with a 1 mm2 cross-sectional area. The specimens were subjected to microtensile testing using EZ-test (Shimadzu) at 1 mm/minute. Data were analyzed using three-way ANOVA and Student's t-Test (p<0.05). Bond strengths to sound dentin with photo- and dual-cure adhesives using total- and self-etch techniques were significantly higher than those to caries-affected dentin. Dual-cure adhesive significantly decreased bond strengths both to sound and caries-affected dentin. The total-etch technique showed no beneficial effect on caries-affected dentin compared with the self-etch technique. Scanning electron microscopic observation of the resin-dentin interfaces revealed that hybrid layers in caries-affected dentin were thicker than those observed in sound dentin with photo- and dual-cure adhesives. Resin infiltration into dentinal tubules of caries-affected dentin was hampered by the presence of mineral deposits.
Atenolol offers better protection than clonidine against cardiac injury in kainic acid‐induced status epilepticus (2015)

Severe seizure activity in this model was clearly associated with altered ECG activity and cardiac pathology. We suggest that modulation of sympathetic activity by atenolol provides a promising cardioprotective approach in status epilepticus.
Switching to criticality by synchronized input (2009)

Meeting abstracts - A single PDF containing all abstracts in this Supplement is available <a href=http:// www.biomedc
Analog Integrated Circuit for Micro-Gyro Interface Realized by Multi-chip Service in Japan (1998)

This paper deals with an analog integrated circuit for micro-machined gyroscopes with capacitive output. The Integrated ciorcuit was fabricated as a part of the first project from the “Micromachining Multi-Chip Service Cooperative Research Committee” organized by The Institute of Electrical Engineers Japan. This multi-chip service project offers a master slice chip with an equivalent of 9 blocks of operational amplifier circuits. Our integrated circuit includes a modulator, demodulator and synchronous rectifier for detecting small changes in the capacitance of a silicon gyroscope. In the paper, the experimental results of fabricated samples will be described.
A trivariate continual reassessment method for phase I/II trials of toxicity, efficacy, and surrogate efficacy (2012)

Recently, many Bayesian methods have been developed for dose finding when simultaneously modeling both toxicity and efficacy outcomes in a blended phase I/II fashion. A further challenge arises when all the true efficacy data cannot be obtained quickly after the treatment so that surrogate markers are instead used (e.g., in cancer trials). We propose a framework to jointly model the probabilities of toxicity, efficacy, and surrogate efficacy given a particular dose. Our trivariate binary model is specified as a composition of two bivariate binary submodels. In particular, we extend the bivariate continual reassessment method (CRM), as well as utilize a particular Gumbel copula. The resulting trivariate algorithm utilizes all the available data at any given time point and can flexibly stop the trial early for either toxicity or efficacy. Our simulation studies demonstrate that our proposed method can successfully improve dosage targeting efficiency and guard against excess toxicity over a variety of true model settings and degrees of surrogacy.
Real World Applications of Virtual Weigh Stations (2009)

Unlike conventional ramp weigh stations, Virtual Weigh Stations and Mainline Weigh-In- Motion (WIM) systems make continuous highway travel possible for trucks that are compliant with weight regulations. This paper focuses on Virtual Weigh Stations, which are increasingly being used to reduce the percentage of overloaded trucks, thereby diminishing excessive vehicle emissions and damage to pavement infrastructure. The Virtual Weigh Station provides a way to unobtrusively monitor commercial vehicle traffic on highways and urban streets. This paper discusses real world applications of the Virtual Weigh Station in diverse locations such as Saskatchewan, Northwest Territories, New York, and Wisconsin.
Clinical characteristics of ovarian cancer patients who underwent enterostomy. (2008)

목적: 본 연구의 목적은 장창냄술을 시행받은 난소암 환자들의 임상적 특징을 살펴보고자 함이다. 방법: 1990년 1월부터 2006년 12월까지 장창냄술을 시행받은 51명의 난소암 환자를 수술의 시기와 적응증에 따라 일차종양감축술군, 이차종양감축술군, 임시수술군으로 분류하여 임상적 특징을 비교하였다. 또한, 예후 인자를 찾기 위하여 임상적 특징 간의 관련성을 조사하였다. 결과: 일차종양감축술군, 이차종양감축술군, 임시수술군의 순서로 나이가 많았고 (P=0.061), 상부소화기증상이 드물었으며 (P=0.000), 공장창냄술이나 회장창냄술보다는 결장창냄술을 시행받았으며 (P=0.037), 수술 후 항암화학요법을 받는 환자가 많았다 (P=0.000). 나이가 많을수록 장창냄술과 관련된 합병증이 증가하였다 (P=0.035). 일차종양감축술군에서 나이가 많을수록 수술 후 잔여 병변이 1 cm 미만일 확률이 낮았다 (P=0.020). 임시수술군에서 수술 전 상부소화기증상이 있는 경우 공장창냄술이나 회장창냄술을 시행받는 경우가 많았고 (P=0.021), 하부소화기증상이 있는 경우에는 모든 환자에서 결장창냄술을 시행받았다 (P=0.005). 결론: 장창냄술을 시행받은 난소암 환자에서 수술의 시기와 적응증에 따라 임상 양상은 차이를 보였다. 임상적 특징들과 수술 전 소화기증상을 주의 깊게 관찰함으로써 장창냄술을 시행받은 난소암 환자들의 수술 후 삶의 질 예측에 도움이 되리라고 생각된다.
Glomerular Filtration Rate in Examined Population of Bosnian Posavina - Region of Balkan Endemic Nephropathy (2010)

Balkan endemic nephropathy (BEN) is chronic tubulointersticial nephritis of unknown aetiology characterized by an insidious onset and gradual progression to end stage renal disease (ESRD). Endemic regions of Bosnia and Herzegovina are Posavina and Semberija, sited at basin of Sava River. In BEN, just like in other chronic renal diseases (CKD), glomerular filtration rate (GFR), is assumed a marker of overall renal function. The aim of this study was to compare GFR in examinees of endemic and non-endemic region for BEN, and between examinees with and without risk factors for BEN within endemic region. Study included 603 inhabitants of Bosnian Posavina, out of whom 386 (65%) from endemic (Domaljevac) and 217 (36%) from non-endemic (Svilaj) village, and it was performed in two phases. The first phase encompassed obtaining anamnestic data (demographic, personal and family history), measurement of arterial blood pressure, and urine dipstick testing (specific gravity, pH, proteins, leukocytes, glucose, ketones, and microalbuminuria). In the second phase, besides repeated urine dipstick test, laboratory blood testing and abdominal ultrasound, with special attention to urinary tract, was also performed. We have compared GFR between examinees of endemic and non-endemic regions for BEN, and between examinees with and without family burden for BEN within endemic region, using MDRD formula for calculating GFR, with cut-off value (5th percentile) based on result of studies performed in European Caucasians in screening for CKD and for establishing stages of CKD in BEN. Medical was used for statistical testing. Out of total number of examined inhabitants (603), 145 examinees were included in the second phase. After exclusion of 17 diabetic patients, 94 (73%) examinees from endemic and 34 (27%) examinees from non-endemic region remained. In the endemic region there were 46 (49%) examinees with and 48 (51%) without family burden for BEN. Overall GFR in examined groups was within physiologic range. There was not statistically significant difference in calculated GFR between examinees of endemic and non-endemic regions for BEN (Mann-Whitney test p=0.104; Fisher's test p=1), neither between examinees with and without family burden for BEN within endemic region (Mann-Whitney test p=0,7393; Fisher's test p=0,263). Overall GFR in examined groups was within physiologic range. There wasn't statistically significant difference in calculated GFR between examinees of endemic and non-endemic regions for BEN, neither between examinees with and without family burden for BEN within endemic region. GFR, no matter how accurately calculated and estimated, does not represent significant biomarker for diagnosis, especially early diagnosis, of BEN, until maybe its overt advanced form.
Capacity of the discrete-time non-coherent memoryless MIMO channels at low SNR (2008)

The capacity of a discrete-time memoryless Gaussian channel, where the channel state information (CSI) is neither available at the transmitter nor at the receiver, is addressed. A closed form expression of the optimal capacity-achieving input distribution at low signal-to-noise ratio (SNR) is derived, and the exact capacity of a non-coherent Single Input Single Output (SISO) channel is given. The derived relations allow to better understanding the capacity of non-coherent channels at low SNR. Then, we compute the non-coherence penalty and give a more precise characterization of the sub-linear term in SNR. Finally, upper and lower bounds on the capacity of a multiple input multiple output (MIMO) channel are derived in terms of its counterpart SISO channel capacity. We show that these bounds are sufficient to characterize the MIMO channel capacity at low SNR.
The compression issues of panoramic video (2002)

The paper proposes efficient data compression techniques for panoramic video. Panoramic videos have been used as a means for representing dynamic scenes or paths along a static environment. They allow the user to change viewpoints interactively at a point in time or space. High-resolution panoramic videos, while desirable, consume a significant amount of storage and bandwidth for transmission, and make real-time decoding very computationally intensive. A high performance MPEG-like compression algorithm, which takes into account the random access requirements and the redundancies of the panoramic video, is presented. The transmission aspects of panoramic video over cable network, LAN and Internet are also briefly discussed.
ChemInform Abstract: The Chemistry and Occurrence of Taxane Derivatives. Part 10. The Photochemistry of Taxine B. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vesicular Trafficking of Tyrosine Kinase Receptors and Associated Proteins in the Regulation of Signaling and Vascular Function (2006)

Receptor tyrosine kinases (RTKs) play a pivotal role in the development and function of the cardiovascular system. Ligand-activated RTKs promote numerous downstream signal transduction pathways that lead to vascular permeability, as well as proliferation, migration, and differentiation of vascular endothelia and smooth muscle cells. Ligand binding also promotes internalization of the activated receptors either to downregulate the signaling via degradation of the ligand/receptor complex or to signal from endosomes. However, the outcomes of receptor internalization via clathrin-dependent or caveolar pathways and trafficking mechanisms are incompletely clarified in vascular systems. Activity modulation through endocytosis and vesicular trafficking significantly impacts downstream targets of RTKs such as endothelial nitric oxide synthase (eNOS) and VE-cadherin. RTKs and their associated targets are also transported to the nucleus, where they may directly impact nuclear signaling. Although the nuclear transport pathways are just beginning to be unraveled, it appears that endocytosis and vesicular trafficking are involved. In this review, we discuss the mechanisms by which activated RTKs and the downstream targets eNOS and VE-cadherin may be internalized and transported to various intracellular compartments. How localization and interacting proteins impact protein function and influence signaling is an important theme, as is the potential for modulating signaling through therapeutic targeting of activated receptors and components of the endocytic machinery.
Robust synthesis of constrained linear state feedback using LMIs and polyhedral invariant sets (2006)

This paper deals with the synthesis of linear feedback controllers for constrained discrete-time linear systems with polytopic uncertainty description. This problem was initially tackled using ellipsoidal robust invariant sets in the paper by Kothare (Kothare et al., Automatica, 1996) leading to an LMI-based optimization problem. The contribution of this paper is twofold. First the aforementioned method is extended to also take into account mixed state/input constraints and cross-terms between states and inputs in the objective function. Secondly, polyhedral invariant sets (Pluymers et al., ACC, 2005) are introduced in the synthesis algorithm in order to eliminate conservative constraint handling. This results in a provably more optimal feedback controller. The resulting method can either be used on-line in a receding horizon fashion to obtain a robust constrained controller or off-line in order to obtain a feedback controller with a guaranteed feasible region for use in dual-mode or other robust model-based predictive control algorithms. A numerical example is given to illustrate the new algorithm
Design, Synthesis and 3D QSAR Based Pharmacophore Study of Novel Imatinib Analogs as Antitumor-Apoptotic Agents (2018)

Most compounds showed potent anticancer activity against both cell lines with IC<sub>50</sub> = 0.14-5.07 μM. Three compounds demonstrated ability to reinforce cell cycle arrest at G1 stage in a manner similar to imatinib. In addition, they induced apoptosis via activation of caspase-3.