gebhart/patrepeval huggingface dataset:
Analysis of human C8 with monoclonal antibodies. Characterization of a monoclonal antibody that recognizes free C8 <i>alpha-gamma</i> subunit. (1988)

The eighth component of human C is essential for the formation of the membranolytic C attack complex. C8 has a unique structure in that two covalently linked chains, C8 alpha and C8 gamma, are associated non-covalently with the third chain, C8 beta. In order to study the structure and assembly of the C8 molecule, a panel of mAb has been produced against the C component C8. Eight of these mAb had reactivity to the C8 alpha-gamma subunit, whereas four reacted with C8 beta. One of the C8 alpha-gamma mAb, C8A2, had specificity for an epitope on the C8 alpha-chain and exhibited no cross-reactivity to any of the other terminal C components, including C8 beta. C8A2 inhibited the hemolytic activity of the C8 alpha-gamma subunit but had no effect on the activity of fluid phase whole C8 or C8 within membrane-bound C5b-8. Functional experiments suggest that C8A2 inhibits C8 alpha-gamma activity by interfering with its interaction with the C8 beta-chain. In an enzyme immunoassay using the C8A2 mAb, free C8 alpha-gamma subunit could be detected in both homozygous and heterozygous C8 beta-deficient serum. However, only low level binding was observed when homozygous C5- and C7-deficient sera were tested. Thus the mAb, C8A2, recognizes an epitope expressed on the C8 alpha-gamma subunit but not on intact C8 and can detect free C8 alpha-gamma in the presence of native C8.
Convection-Diffusion Analysis of Sedimentation in Initially Dilute Solids-Suspensions (1984)

The settling of suspended solids in solids-suspensions is treated from the viewpoint of the relative fluxes established as a result of the upward diffusion of water and the downward convection of the solids. Calculated diffusion coefficients are used to predict the settling rate of the solids and the solids concentration profile. Predictions for various experiments and a field settling pond are compared with measured values.
THE ROLE OF MICROSOMES IN THE INCORPORATION OF AMINO ACIDS INTO PROTEINS (1954)

These studies are an extension of previous findings of a relationship between ribose nucleic acid and protein synthesis (Brachet, Caspersson, Borsook, Keller, Siekevitz, Mirsky). In vivo experiments have been described which show that 70 per cent or more of the initial incorporation of leucine-C 14 or valine-C 14 in the liver occurs in the protein of the microsome fraction, which contains most of the cytoplasmic ribose nucleic acid. A straight line rate of incorporation of valine-C 14 into microsome protein has been found during the first few minutes after intravenous injection of the labeled amino acid. The uptake of leucine or valine into microsome protein in these experiments is approximately 2 per cent per hour. Experiments on a cell-free system have also been reported, showing that the microsome fraction and the "soluble fraction" of the liver cell are both essential for incorporation. This incorporation occurs almost entirely into the protein of the microsome fraction.
One‐Dimensional Model for Analysis of CRC Pavement Growth (1992)

A one‐dimensional model for predicting the structural response of continuously reinforced concrete (CRC) pavement due to increasing temperature and alkali‐silica reaction (ASR), considering slip between concrete and reinforcing bar and friction between concrete and subbase material, is presented in this paper. The slip‐stress function is modeled by a three‐part linear function. The subbase friction stress function is modeled by a two‐part linear function. The solution procedures of displacement functions for a semi‐infinite length slab are given. The unknown coefficients in the displacement functions are determined by finding the roots of the system of nonlinear equations. A simple no‐slip model is also used both for providing an initial guess and for verifying the numerical results. This model provides a more rational approximation of the structural response of CRC pavement.
Viszerale Resorption von intraabdominell insuffliertem Kohlendioxid beim Schwein (1999)

The IAP dependent increase in CO2 resorption is limited due to an IAP related occlusion of the peritoneal capillaries and the limited expansion of peritoneal diffusion area. In this model, it was possible to show that visceral fraction is about one third of the total intraperitoneal carbon dioxide resorption and that this fraction depends on portal venous blood flow. Thus, a decrease in total CO2 resorption may indicate a reduction in portal venous blood flow.
<title>Optical breakdown laser-generated sound in water</title> (1998)

One possibility for communicating from an airplane above water surface to submarine in sea involves the use of laser- generated sound. In this paper, we introduce the way to generate strong optical breakdown acoustic signal in a limited large volume of water but enough to do basic work in air- submarine communication realm. The optical breakdown mechanism of strong Nd:YAG laser pulse with water generates acoustic signals in water having pulse widths about 25 microseconds and a frequency spectrum peak about 58 kHz. And, its sound source level (SSL) of 196 dB for low frequencies less than 58 kHz is sufficient to be detected at far distant deep in water. This makes a stride for pursuing the feasibility of laser-acoust air-submarine communication.
Design and Implementation of Discrete-Time Filters For Efficient Rate-Conversion Systems (2007)

Oversampled A-to-D converters commonly rely on sharp-cutoff, discrete-time filters that operate at fast input sampling rates. Filter design techniques for such filters typically use the length of the impulse response as an indicator of computational cost, assuming that each filter tap requires a multiplier in Parks, T. W., et al, (1972). This paper describes methods for designing zero-phase filters with sparse impulse responses, i.e., with many zero-valued coefficients, and presents rate-conversion structures for efficiently implementing these designs. By combining polyphase methods and delay-line folding, the structures presented require only one multiplier for each unique value in the impulse response of the filter.
Escalated as Compared with Standard Doses of Doxorubicin in BACOP Therapy for Patients with Non-Hodgkin's Lymphoma (1993)

In patients with advanced-stage intermediate- or high-grade non-Hodgkin's lymphoma, escalating the dose of doxorubicin in the BACOP regimen increases toxicity but does not improve the rate of response or survival.
Metastases to the pancreas and peripancreatic lymph nodes from carcinoma of the right side of the colon: CT findings in 12 patients. (1993)

Clinical features and CT findings in patients with pancreatic metastases from carcinoma of the colon are similar to those of primary pancreatic ductal adenocarcinomas. The diagnosis of metastasis should be considered when a patient has a pancreatic mass and a history of colon carcinoma.
Improving mechanical robustness of ultralow-k SiOCH plasma enhanced chemical vapor deposition glasses by controlled porogen decomposition prior to UV-hardening (2010)

We report a new curing procedure of a plasma enhanced chemical vapor deposited SiCOH glasses for interlayer dielectric applications in microelectronic. It is demonstrated that SiOCH glasses with improved mechanical properties and ultralow dielectric constant can be obtained by controlled decomposition of the porogen molecules used to create nanoscale pores, prior to the UV-hardening step. The Young’s modulus (YM) of conventional SiOCH-based glasses with 32% open porosity hardened with porogen is 4.6 GPa, this value is shown to increase up to 5.2 GPa with even 46% open porosity, when the glasses are hardened after porogen removal. This increase in porosity is accompanied by significant reduction in the dielectric constant from 2.3 to 1.8. The increased YM is related to an enhanced molecular-bridging mechanism when film is hardened without porogen that was explained on the base of percolation of rigidity theory and random network concepts.
Doped ZnO 1D Nanostructures: Synthesis, Properties, and Photodetector Application (2014)

In the past decades, the doping of ZnO one-dimensional nanostructures has attracted a great deal of attention due to the variety of possible morphologies, large surface-to-volume ratios, simple and low cost processing, and excellent physical properties for fabricating high-performance electronic, magnetic, and optoelectronic devices. This article mainly concentrates on recent advances regarding the doping of ZnO one-dimensional nanostructures, including a brief overview of the vapor phase transport method and hydrothermal method, as well as the fabrication process for photodetectors. The dopant elements include B, Al, Ga, In, N, P, As, Sb, Ag, Cu, Ti, Na, K, Li, La, C, F, Cl, H, Mg, Mn, S, and Sn. The various dopants which act as acceptors or donors to realize either p-type or n-type are discussed. Doping to alter optical properties is also considered. Lastly, the perspectives and future research outlook of doped ZnO nanostructures are summarized.
Modeling the temperature dependence of the thermal conductivity of aluminum nitride (1989)

Data on the thermal conductivity of commercially available aluminum nitride substrates, over the temperature range of 20-500 K, is analyzed using the Klemens-Callaway model. Parameters in this model which include crystallite size and impurity concentration, are determined through a nonlinear least squares fitting routine. The resulting parameters are compared with values obtained from other experimental techniques such as scanning electron microscopy (SEM) and proton induced x-ray emission (PIXE). A graphical method has been developed for the estimation of impurity concentration and crystallite size from low temperature thermal conductivity data. 19 refs., 3 figs., 3 tabs.
Creating Rechargeable Antithrombotic Surfaces for Implantation via Enzyme-Mediated Ligation: A Novel System for Keeping Medical Devices Functional (2017)

Patel, Madhukar S. MD, MBA; Ham, Hyun Ok PhD; Haller, Carolyn A.; Dai, Erbin MD; Liu, Liying L.L. MD; Liu, David R. PhD; Liu, Jian PhD; Chaikof, Elliot L. MD, PhD, FACS Author Information
Detecting Crystalline Nonequilibrium Phases on the Nanometer Scale (2012)

The use of Automated electron Diffraction Tomography (ADT) is presented as a novel approach for crystallization studies at the nanometer scale for nonequilibrium phases. Here, ADT was applied to elucidate the structural identity of the recently reported hexagonal morphology of caffeine crystals, which grow only on specific surfaces. Caffeine was crystallized from solution on a specially treated TEM carbon grid. The analysis of ADT data revealed that the lattice parameters of these hexagons match those of the high temperature α-form of caffeine. Furthermore, it was observed that in this hexagonal morphology, the α-form remained stable for a prolonged period of time. The stabilization of hexagons can be interpreted in terms of enhanced interactions with the supporting surfaces.
DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs) (2020)

The proper communication between gut and brain is pivotal for the maintenance of health and, dysregulation of the gut-brain axis can lead to several clinical disorders. In Parkinson's disease (PD) 85% of all patients experienced constipation many years before showing any signs of motor phenotypes. For differential diagnosis and preventive treatment, there is an urgent need for the identification of biomarkers indicating early disease stages long before the disease phenotype manifests. DJ-1 is a chaperone protein involved in the protection against PD and genetic mutations in this protein have been shown to cause familial PD. However, how the deficiency of DJ-1 influences the risk of PD remains incompletely understood. In the present study, we provide evidence that DJ-1 is implicated in shaping the gut microbiome including; their metabolite production, inflammation and innate immune cells (ILCs) development. We revealed that deficiency of DJ-1 leads to a significant increase in two specific genera/species, namely Alistipes and Rikenella. In DJ-1 knock-out (DJ-1<sup>-/-</sup>) mice the production of fecal calprotectin and MCP-1 inflammatory proteins were elevated. Fecal and serum metabolic profile showed that malonate which influences the immune system was significantly more abundant in DJ-1<sup>-/-</sup> mice. DJ-1 appeared also to be involved in ILCs development. Further, inflammatory genes related to PD were augmented in the midbrain of DJ-1<sup>-/-</sup> mice. Our data suggest that metabolites and inflammation produced in the gut could be used as biomarkers for PD detection. Perhaps, these metabolites and inflammatory mediators could be involved in triggering inflammation resulting in PD pathology.
Modeling the action of zeitgebers on the human circadian system: comparisons of simulations and data (1984)

In our two-oscillator model for the human circadian timing system, the effect of an environmental synchronizing cycle (zeitgeber) is determined by the periods of the two oscillators and of the zeitgeber and by the zeitgeber strength. The oscillators x and y are postulated to regulate the core temperature and rest-activity rhythms, respectively. From published examples of experiments in which human subjects were exposed to artificial zeitgebers, it is possible to derive estimates of the periods of the core temperature and/or the rest-activity rhythms and the zeitgeber. Two strengths of zeitgeber input to the model that correspond to two of the common zeitgeber regimes used in human entrainment studies have now been elucidated. Thus specific model simulations can be generated for each of the available examples of entrainment of human subjects by artificial zeitgebers. Such simulations indicate that the model can reproduce, with remarkable subtlety, the types of full and partial entrainment observed experimentally. The model is thus demonstrated to accommodate the period and phase control of endogenous rhythms by environmental zeitgebers, which is a crucial functional attribute of circadian timing systems.
Exploiting flexibly assignable work to improve load balance (2002)

In many applications of parallel computing, distribution of the data unambiguously implies distribution of work among processors. But there are exceptions where some tasks can be assigned to one of several processors without altering the total volume of communication. In this paper, we study the problem of exploiting this flexibility in assignment of tasks to improve load balance. We first model the problem in terms of network flow and use combinatorial techniques for its solution. Our parametric search algorithms use maximum flow algorithms for probing on a candidate optimal solution value. We describe two algorithms to solve the assignment problem with $\log W_T$ and $|P|$ probe calls, where $W_T$ and $|P|$, respectively, denote the total workload and number of processors. We also define augmenting paths and cuts for this problem, and show that any algorithm based on augmenting paths can be used to find an optimal solution for the task assignment problem. We then consider a continuous version of the problem, and formulate it as a linearly constrained optimization problem, i.e., $ \min \|Ax\|_\∞,\; \rm s.t.\; Bx=d$. To avoid solving an intractable ∞-norm optimization problem, we show that in this case minimizing the 2-norm is sufficient to minimize the ∞-norm, which reduces the problem to the well-studied linearly-constrained least squares problem. The continuous version of the problem has the advantage of being easily amenable to parallelization.
Synthesis and properties of 2'-deoxy-2'-thiocytidine (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and properties of 2'-deoxy-2'-thiocytidineArvind D. Patel, Wayne H. Schrier, and Joseph NagyvaryCite this: J. Org. Chem. 1980, 45, 24, 4830–4834Publication Date (Print):November 1, 1980Publication History Published online1 May 2002Published inissue 1 November 1980https://pubs.acs.org/doi/10.1021/jo01312a005https://doi.org/10.1021/jo01312a005research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Distinct Cytoplasmic Regions of the Prolactin Receptor Are Required for Prolactin-induced Calcium Entry (1998)

Two cytoplasmic regions of the prolactin (PRL) receptor are well documented for their participation in PRL signal transduction, the membrane proximal box 1 and the COOH-terminal region. In order to study the role of these regions in PRL-induced Ca2+ increase, we use Chinese hamster ovary (CHO) cells stably transfected with mutated PRL receptor cDNA. These cells express the long form of PRL receptor deleted from box 1 (CHO Delta1 cells) or the 141 amino acids of the COOH-terminal region (CHO H3 cells). The patch-clamp technique in "whole-cell" configuration and microfluorimetric techniques were used singly or in combination. Data obtained for these cells were compared with those we have recently published using CHO cells expressing the wild-type long form of the PRL receptor (CHO TSE32). In contrast to CHO TSE32 cells, exposure of CHO Delta1 or H3 cells to PRL (0.05-50 nM) did not modify [Ca2+]i. We have previously shown that the PRL-induced calcium influx via voltage-insensitive, Ca2+ channels was due to the activation of tyrosine kinase-dependent K+ channels that hyperpolarize the CHO TSE32 cell membrane (hyperpolarization-driven Ca2+ influx). Therefore, two events are involved in PRL-induced Ca2+ changes (i) JAK2-activation of K+ channels and (ii) intracellular messenger-opening of Ca2+ channels. In CHO Delta1 cells, PRL (0.05-50 nM) neither hyperpolarized the membrane potential nor stimulated the JAK2-dependent K+ current, confirming the pivotal role played by box 1/JAK2 in the PRL-induced activation of K+ channels. However, when these cells were voltage-clamped below the resting membrane potential, application of 5 nM PRL resulted in an increase in Ca2+ influx. Therefore, box 1/JAK2 was not involved in the opening of these Ca2+ channels. In CHO H3 cells, 5 nM PRL activated the K+ current and hyperpolarized the membrane potential without any effect on [Ca2+]i. Moreover, PRL was also ineffective on CHO H3 cells voltage-clamped below the resting membrane potential. Therefore, the COOH-terminal region is involved in the production of the intracellular messenger that opens voltage-independent Ca2+ channels. We conclude from these findings that box 1 and COOH-terminal regions are both needed for PRL-induced Ca2+ changes.
SH-5: the 64 bit superH architecture (2000)

A collaborative effort of Hitachi and STMicroelectronics, the SH-5 is the latest member of the SuperH microprocessor series. Its CPU core is the first implementation of a new instruction set architecture consisting of 32-bit instructions, 64-bit registers, SIMD (single-instruction, multiple-data) instructions for multimedia applications, and a compatibility mode supporting the 16-bit SuperH instruction set. Embodying an emerging philosophy of embedded-core design, the SH-5 provides a platform for a wide range of applications: set top cable boxes, digital TV, voice over IP (Internet telephony), network processing, PDAs (personal digital assistants), Internet appliances, in-car information systems, game machines, and so on. A single cost-effective, optimum design that will cater to the requirements of such a wide range of applications is not feasible. So the SH-5 core supports a carefully selected set of functions critical to meeting the performance, power, and code-size requirements of these applications. At the same time, it: provides features that ease integration into a system on chip (SOC) that uses application-specific hardware modules to cater to specific requirements.
Development of 4WS/4WD Experimental Vehicle: platform for research and education in mechatronics (2011)

This paper presents the development of scaled four-wheel steering and driven (4WS/4WD) vehicle ideally suited as a research and educational platform in mechatronics. Basic kinematic and dynamic models are presented as the base for vehicle computer simulation as well as for the parameter estimation using variants of Kalman filter. Further the structure of control and power electronic system is briefly described. Next, several examples of practical results dealing with parameter and state estimation are presented as a demonstration of the use of platform in education and research. The main contribution of the platform presented here is: the demonstration of wide range of problems including kinematics, embedded control and system identification; the high level of integration and complexity of solution which is typical for mechatronics; and the close relation to automotive engineering which is substantial in mechatronics but which also features the high level of attraction and motivation for students.
Computer simulation of ventricular wall motion using the finite element method. (1989)

To investigate how changes in the mechanical characteristics of the myocardium caused by cardiac diseases affect ventricular wall motion, a new computer program to simulate wall motion using the finite element method has been developed. A simple two-dimensional finite element model of the left ventricle is designed with an idealized tension-length curve applied to each element. Pathological changes in the ischemic process are induced in a certain portion of the model to make it possible to evaluate the relationship between the type and degree of changes and abnormal ventricular wall motion (i.e., hypokinesis, akinesis, and dyskinesis). Assumption of plastic deformation at the affected site of the model reproduced the genesis of a ventricular aneurysm. The model is then transformed into a three-dimensional wire frame structure, and the results can viewed from any perspective. These simulations enable the semiquantitative comprehension of cardiac wall motion without need for complicated physiological experiments and may be applied to human cardiac motion in combination with data obtained from cardiac scintigraphy, echocardiography, ventriculography, or cine-CT.
Preferred conformations of pilocarpine, pilocarpine.HCl and isopilocarpine.HCl in solution, deduced from 200 MHz <sup>1</sup>H NMR spectra (1984)

Abstract The 200 MHz 1 H NMR spectra of pilocarpine, pilocarpine.HCl and isopilocarpine.HCl have been studied. Evidence is presented for the preferred conformations of the compounds in aqueous solution, with the methylimidazolyl moiety antiperiplanar with respect to the α‐carbon of the butanolide ring.