gebhart/patrepeval huggingface dataset:
Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase (2015)

o-Succinylbenzoyl-CoA synthetase, or MenE, is an essential adenylate-forming enzyme targeted for development of novel antibiotics in the menaquinone biosynthesis. Using its crystal structures in a ligand-free form or in complex with nucleotides, a conserved pattern is identified in the interaction between ATP and adenylating enzymes, including acyl/aryl-CoA synthetases, adenylation domains of nonribosomal peptide synthetases, and luciferases. It involves tight gripping interactions of the phosphate-binding loop (P-loop) with the ATP triphosphate moiety and an open-closed conformational change to form a compact adenylation active site. In MenE catalysis, this ATP-enzyme interaction creates a new binding site for the carboxylate substrate, allowing revelation of the determinants of substrate specificities and in-line alignment of the two substrates for backside nucleophilic substitution reaction by molecular modeling. In addition, the ATP-enzyme interaction is suggested to play a crucial catalytic role by mutation of the P-loop residues hydrogen-bonded to ATP. Moreover, the ATP-enzyme interaction has also clarified the positioning and catalytic role of a conserved lysine residue in stabilization of the transition state. These findings provide new insights into the adenylation half-reaction in the domain alteration catalytic mechanism of the adenylate-forming enzymes.
Design and Characterization of Auxotrophy-Based Amino Acid Biosensors (2012)

Efficient and inexpensive methods are required for the high-throughput quantification of amino acids in physiological fluids or microbial cell cultures. Here we develop an array of Escherichia coli biosensors to sensitively quantify eleven different amino acids. By using online databases, genes involved in amino acid biosynthesis were identified that - upon deletion - should render the corresponding mutant auxotrophic for one particular amino acid. This rational design strategy suggested genes involved in the biosynthesis of arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, threonine, tryptophan, and tyrosine as potential genetic targets. A detailed phenotypic characterization of the corresponding single-gene deletion mutants indeed confirmed that these strains could neither grow on a minimal medium lacking amino acids nor transform any other proteinogenic amino acid into the focal one. Site-specific integration of the egfp gene into the chromosome of each biosensor decreased the detection limit of the GFP-labeled cells by 30% relative to turbidometric measurements. Finally, using the biosensors to determine the amino acid concentration in the supernatants of two amino acid overproducing E. coli strains (i.e. ΔhisL and ΔtdcC) both turbidometrically and via GFP fluorescence emission and comparing the results to conventional HPLC measurements confirmed the utility of the developed biosensor system. Taken together, our study provides not only a genotypically and phenotypically well-characterized set of publicly available amino acid biosensors, but also demonstrates the feasibility of the rational design strategy used.
How successful organizations strategically manage their analytic talent (2010)

Purpose Because analytics are increasingly becoming a key source of competitive advantage, attracting, engaging and retaining analytical talent and building an organizations' analytical capability is now a key skill top management needs to learn. This paper aims to investigate this issue. Design/methodology/approach Given that analytics is a relatively new management discipline and that only a few leading companies manage the talent it requires as a strategic resource, the authors collected their best practices. Findings The paper specifies the four main practices that top executives need to follow to create and develop a talent‐powered analytical organization. Research limitations/implications The authors offer anecdotal research on leading companies. Practical implications What distinguishes talent‐powered analytical organizations is their ability to unleash their analysts' talents to maximize and continually expand the company's analytical capabilities. Originality/value By building and aligning the four key talent management capabilities revealed in this paper, organizations can maximize the strategic impact of their analytical talent and continually expand the organization's collective analytical capabilities.
1.2-V Low-Power Multi-Mode DAC+Filter Blocks for Reconfigurable (WLAN/UMTS, WLAN/Bluetooth) Transmitters (2006)

Two versions of a baseband block composed by a 8-bit current-steering DAC and a fourth-order low-pass reconstruction filter are realized in a 0.13-mum CMOS technology to be embedded in multistandard wireless transmitters. In order to satisfy the specifications of WLAN IEEE 802.11a/b/g, UMTS, and Bluetooth standards, the proposed devices can be digitally programmed, adjusting the DAC conversion frequency and the low-pass filter cut-off frequency. For the WLAN case, the DAC operating frequency and the filter bandwidth are set to 100 MHz and 11 MHz, respectively, for the UMTS case, they are equal to 50 MHz and 2.5 MHz, and for the Bluetooth case, they are equal to 50 MHz and 1 MHz. The first device is reconfigurable between WLAN and UMTS, and the second one between WLAN and Bluetooth. The two fabricated devices operate from a single 1.2-V supply voltage and occupy a 0.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 0.7 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> die area, respectively. The power consumption is optimized according to the operation mode and is 8 mW in WLAN mode, 8.4 mW in UMTS mode, and 5.4 mW in Bluetooth mode. For all the considered standards, the measured OIP3 is larger than 28 dBm, while the SFDR is 54 dB for WLAN, 61 dB for UMTS, and 63 dB for Bluetooth
Color Theory and Color Imaging Systems: Past, Present and Future (1998)

James Clerk Maxwell demonstrated the first color photograph in a lecture to the Royal Society of Great Britain in 1861. He used the demonstration to illustrate Thomas Young's idea that human vision uses three kinds of light sensors. This demonstration led to a great variety of color photographic systems using both additive and subtractive color. Today, we have image-capture devices that are photographic, video, still, and scanning. We have hardcopy printers that are electrophotographic, ink jet, thermal and holographic, as well as displays that use cathode ray tubes, liquid-crystal and other light emission color devices. The major effort today is to get control of all these technologies so that the user can, without effort, move a color digital image from one technology to another without changing the appearance of the image. The strategy of choice is to use colorimetry to calibrate each device. If all prints and displays sent the same colorimetric values from every pixel, then the images, regardless of the display, would appear identical. The problem with matching prints and displays is that they have very different color gamuts. A more satisfactory solution is needed. In my view, the future emphasis of color research will be in models of human vision. The purpose of these models will shift from calculating color matches to calculating color sensations. All the technologies listed above work one pixel at a time. The response at every pixel is dependent on the input at that pixel, regardless of whether the imaging system is chemical, photonic, or electrical. Humans are different. The color they see at a pixel is controlled by that pixel and all the other pixels in the field of view. Human color vision uses a spatial calculation involving the whole image. Except for human vision, all other color systems have the same output from a single input. In other words, if an input pixel has a value of 128, and the image processing changes that value to 155, then all pixels with 128 in will have 155 out. Human vision is unique among color imaging systems because a single input value (128) will generate a range of output values (0, or 55, or 128, or 255), depending on the values of other pixels in the image. Despite the remarkable progress in our ability to control the placement of dyes and pigments on paper, we must now return to the study of Maxwell's interest—color theory—for the next advancements in color systems. In the future, we will see more models that compute the color appearance from spatial information and write color sensations on media, rather than attempting to write the quanta catch of visual receptors.
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer (2008)

At the time of clinical detection proteases are more sensitive indicators for colorectal cancer than the commonly used tumor markers. Determinations of CATB, CATL and PAI-1 have a major prognostic impact in patients with colorectal cancer.
Green Solvents–Progress in science and application (2009)

Walter Leitner, Scientific Editor, introduces the themed issue based on the “Green Solvents–Progress in science and application” conference held in Friedrichshafen, Germany, from 28 September to 2 October 2008.
A new Sequential Switching Shunt Regulator Digital Shunt Regulator (S3R-DSR) for Solar Array Regulators (2006)

This work describes the principles of the sequential switching shunt regulator-digital shunt regulator, S3R-DSR, a novel approach to implement the solar array regulator. This is especially devoted to overcome the problems derived from the high solar array parasitic capacitance that exhibits the present (high power) telecommunications satellites
Sosialisasi Kewirausahaan dalam Upaya Peningkatan UMKM Desa Palangan Kecamatan Karangbinangun Kabupaten Lamongan (2020)

Seiring berkembangnya zaman dunia teknologi semakin berkembang, sehingga UMKM perekonomian masyarakat harus mengikuti alur perkembangan teknologi untuk mempertahankan eksistensi dalam menjalankan bisnis dan usaha, karena Sektor Usaha Mikro Kecil dan Menengah (UMKM) memiliki peran penting dalam mendorong pertumbuhan. perekonomian Indonesia. UMKM memiliki andil sebesar 85% dalam penyerapan tenaga kerja. Dalam suatu usaha dibutuhkan studi mengenai kelayakan dari usaha tersebut. Namun kenyataannya masyarakat hanya terfokus pada status kerja sebagai karyawan diperusahaan untuk mendapatkan penghasian. Karena itulah pengembangan masyarakat dengan metode sosialisasi penanaman jiwa kewirausahaan dan bisnis online dilakukan untuk membantu memotivasi masyarakat untuk menjalankan usaha mandiri. Pemberdayaan merujuk pada kemampuan seseorang, khususnya kelompok lemah untuk memiiki akses terhadap sumber-sumber produktif yang memungkinkan mereka dapat meningkatkan pendapatannya dan berpartisipasi dalam proses pembangunan serta pengambilan keputusan. Hasil dari penelitian ini menunjukkan bahwa masyarakat Desa Palangan Kecamatan Karangbinangun memiliki potensi yang besar untuk mengembangkan perekonomian desa melalui UMKM. Faktor pendukung dalam pengembangan masyarakat di bidang ekonomi ini meliputi sumber daya alam dan sumber daya manusia yang melimpah serta partisipasi masyarakan yang cukup tinggi. Sedangkan faktor penghambatnya adalah keterbatasan modal, sarana dan prasarana.
<title>Laser speckle contrast analysis (LASCA) for flow measurement</title> (1997)

Laser light, when scattered from a moving object or fluid, fluctuates in intensity. These fluctuations can yield information about the velocity of the scatterers involved. Most techniques analyze the temporal fluctuations of a single speckle. For information on the spatial distribution of velocities, some form of scanning is necessary. Exceptions include speckle photography and particle image velocimetry, which are full-field, double-exposure methods for measuring lateral velocities and flow. Another full- field technique, laser speckle contrast analyses, has the additional advantages of being a relatively cheap, single- exposure technique operating in quasi-real time and sensitive to both lateral and line-of-sight motion. LASCA was originally developed to monitor blood flow, but these advantages should also be useful in industrial flow measurement.
Verification of Implementations of Cryptographic Hash Functions (2017)

Cryptographic hash functions have become the basis of modern network computing for identity authorization and secure computing; protocol consistency of cryptographic hash functions is one of the most important properties that affect the security and correctness of cryptographic implementations, and protocol consistency should be well proven before being applied in practice. Software verification has seen substantial application in safety-critical areas and has shown the ability to deliver better quality assurance for modern software; thus, applying software verification to a protocol consistency proof for cryptographic hash functions is a reasonable approach to prove their correctness. Verification of protocol consistency of cryptographic hash functions includes modeling of the cryptographic protocol and program analysis of the cryptographic implementation; these require a dedicated cryptographic implementation model that preserves the semantics of the code, efficient analysis of cryptographic operations on arrays and bits, and the ability to verify large-scale implementations. In this paper, we propose a fully automatic software verification framework, VeriHash, that brings software verification to protocol consistency proofs for cryptographic hash function implementations. It solves the above challenges by introducing a novel cryptographic model design for modeling the semantics of cryptographic hash function implementations, extended array theories for analysis of operations, and compositional verification for scalability. We evaluated our verification framework on two SHA-3 cryptographic hash function implementations: the winner of the NIST SHA-3 competition, Keccack; and an open-source hash program, RHash. We successfully verified the core parts of the two implementations and reproduced a bug in the published edition of RHash.
The quantum ten: a story of passion, tragedy, ambition and science (2008)

The article reviews the book Quantum Ten: A Story of Passion, Tragedy, Ambition, and Science, by Sheilla Jones.
A dynamic capability maturity model for improving cyber security (2013)

Cyber attacks continue to proliferate, with increasing sophistication and severity. Businesses and government agencies must establish robust governance, cultures, and data management processes to minimize vulnerability to such threats and ensure effective responses. Capability Maturity Models (CMMs) have been proposed to address this critical need; they enable organizations to benchmark their Cyber Security processes against a framework of recognized best practices. Unfortunately, CMMs are inherently static and diagnostic: they help identify maturity gaps, but are not directly actionable. This paper describes how to extend an existing Cyber Security CMM into a dynamic performance management framework through an intuitive Model-Simulate-Analyze methodology. This software-based framework enables organizations to formulate plans for improving their Cyber Security maturity levels; test and validate or refine those plans prior to roll-out; and monitor execution results to detect emerging problems and make appropriate mid-course adjustments to ensure success.
Solution of Maxwell's equations for log-periodic dipole antennas (1970)

A theory of the log-periodic dipole antenna, which is a solution of the antenna boundary-value problem, is presented here. The theory is derived from Maxwell's equations by solving the wave equation in cylindrical coordinates and satisfying all boundary conditions. The theory is not limited to the log-periodic dipole antenna, but can be easily modified and applied to other antenna configurations using parallel linear elements. The radiation coupling between all antenna elements is taken into account; the calculated results show good agreement with the measurements. Current distributions, radiation patterns, and antenna input impedances are considered, and the application of this theory to the problem of optimal log-periodic dipole antennas is presented as well. Such an antenna obtained by numerical computation is discussed in detail.
Emphasis: Our Prospectus for This Issue… (1968)

Research Article| November 01 1968 Emphasis: Our Prospectus for This Issue… Norman O. Brown Norman O. Brown Search for other works by this author on: This Site Google Theater (1968) 1 (3): 4–5. https://doi.org/10.1215/00440167-1-3-4 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Norman O. Brown; Emphasis: Our Prospectus for This Issue…. Theater 1 November 1968; 1 (3): 4–5. doi: https://doi.org/10.1215/00440167-1-3-4 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsTheater Search Advanced Search The text of this article is only available as a PDF. Copyright 1968 by yale/theatre1968 Article PDF first page preview Close Modal You do not currently have access to this content.
Data Processing in Current 3D Robotic Perception Systems (2015)

This chapter introduces the data processing methods for two typical robotic perception systems: light detection and ranging (LIDAR)-based and Flash LIDAR Camera (FLC)-based systems. The most popular 3D perception sensors in robotics include stereovision system and light detection and ranging (LIDAR). The representative applications of stereovision have been demonstrated in NASA's Mars Exploration Rover [4, 5] program and the DARPA's Learning Applied to Ground Robots [6–9] program. A LIDAR system outperforms a stereovision system in terms of the completeness and accuracy of range data. An FLC illuminates the entire scene with a single laser pulse (or modulated infrared light) and focuses the image onto the 3D sensor's focal plane array (FPA). The sensors used for mapping and navigation include a 2D LIDAR and a three-axis fiber optic gyro. A robotic device is a portable robotic system with navigational functions such as positioning, obstacle detection, and scene recognition.
Holotomography: Quantitative phase tomography with micrometer resolution using hard synchrotron radiation x rays (1999)

Because the refractive index for hard x rays is slightly different from unity, the optical phase of a beam is affected by transmission through an object. Phase images can be obtained with extreme instrumental simplicity by simple propagation provided the beam is coherent. But, unlike absorption, the phase is not simply related to image brightness. A holographic reconstruction procedure combining images taken at different distances from the specimen was developed. It results in quantitative phase mapping and, through association with three-dimensional reconstruction, in holotomography, the complete three-dimensional mapping of the density in a sample. This tool in the characterization of materials at the micrometer scale is uniquely suited to samples with low absorption contrast and radiation-sensitive systems.
Managing the Computational Chemistry Big Data Problem: The <b>ioChem-BD</b> Platform (2014)

We present the ioChem-BD platform ( www.iochem-bd.org ) as a multiheaded tool aimed to manage large volumes of quantum chemistry results from a diverse group of already common simulation packages. The platform has an extensible structure. The key modules managing the main tasks are to (i) upload of output files from common computational chemistry packages, (ii) extract meaningful data from the results, and (iii) generate output summaries in user-friendly formats. A heavy use of the Chemical Mark-up Language (CML) is made in the intermediate files used by ioChem-BD. From them and using XSL techniques, we manipulate and transform such chemical data sets to fulfill researchers' needs in the form of HTML5 reports, supporting information, and other research media.
Improving Salt Tolerance of Zea Mays L. Plants by Presoaking Their Grains in Glycine Betaine. (2009)

2 Absatract: The present investigation was carried out to study the effect of post-emergence soil treatment with different salinity levels (50, 100, and 150 mM NaCl) on growth characteristics, 3 endogenous phytohormones (IAA, GA , zeatin, zeatin riboside, ABA and ethylene), photosynthetic pigments, carbohydrate contents, mineral ions composition, total amino nitrogen and proline, total soluble protein and protein profile of 30-day old Zea mays L. plants cv. Giza 2 resulted from grains soaked in water or the osmoprotectant glycine betaine for 12 hours at 28°C ± 2. Glycine betaine was shown to improve salt tolerance in Zea mays L. cv. Giza by protecting endogenous phytohormones from damage induced by salinity stress. It is able also to improve the vital properties of stressed Zea mays plants through protecting chloroplast membrane, preserving photosynthetic pigments, enhancing osmotic adjustment and turgor maintenance by accumulating organic osmolytes (total amino nitrogen, proline, total soluble protein and total soluble sugars) and inorganic osmolytes (K , M g and Ca ions). Glycine betaine was shown also to enable Zea mays plants to cope with salinity via alteration of gene expression which led to the appearance of new proteins and / or increased the intensities of the other that may be involved in increasing the tolerance of Zea mays plants.
Mechanisms of transactivation by nuclear factor of activated T cells-1. (1996)

Nuclear factor of activated T cells-family proteins (NFAT1/NFATp, NFATc, NFAT3, and NFAT4/NFATx/NFATc3) play a key role in the transcription of cytokine genes and other genes during the immune response. We have defined the mechanisms of transactivation by NFAT1. NFAT1 possesses two transactivation domains whose sequences are not conserved in the other NFAT-family proteins, and a conserved DNA-binding domain that mediates the recruitment of cooperating nuclear transcription factors even when it is expressed in the absence of other regions of the protein. The activity of the NH2-terminal transactivation domain is modulated by an adjacent regulatory region that contains several conserved sequence motifs represented only in the NFAT family. Our results emphasize the multiple levels at which NFAT-dependent transactivation is regulated, and predict significant differences in the architecture of cooperative transcription complexes containing different NFAT-family proteins.
Double Rayleigh backscattering in long-haul transmissionsystems employing distributed and lumped fibre amplifiers (1995)

Double Rayleigh backscattering in long-haul transmission systems employing ‘lumped’ and distributed fibre amplifiers has been analysed. We find that, for singlemode fibre employing ‘lumped’ erbium-doped fibre amplifiers (EDFAs) with isolators on both sides of the EDFAs, the degradation is very small; however, for systems using ‘lumped’ praseodymium-doped fluoride fibre amplifiers or distributed EDFAs the power penalties can be large.