gebhart/patrepeval huggingface dataset:
The Role of Conversation Context for Sarcasm Detection in Online Interactions (2017)

Computational models for sarcasm detection have often relied on the content of utterances in isolation. However, speaker's sarcastic intent is not always obvious without additional context. Focusing on social media discussions, we investigate two issues: (1) does modeling of conversation context help in sarcasm detection and (2) can we understand what part of conversation context triggered the sarcastic reply. To address the first issue, we investigate several types of Long Short-Term Memory (LSTM) networks that can model both the conversation context and the sarcastic response. 1 We show that the conditional LSTM network To address the second issue, we present a qualitative analysis of attention weights produced by the LSTM models with attention and discuss the results compared with human performance on the task.
Biochemical characterization of Leishmania (Viannia) braziliensis and Leishmania (Viannia) peruviana by isoenzyme electrophoresis (1990)

Leishmanial organisms isolated from 24 patients with Andean cutaneous leishmaniasis (uta) and from 7 with sylvatic leishmaniasis in both cutaneous and mucosal forms were characterized on the basis of their isoenzyme profiles for 13 enzymes using both cellulose acetate (CA) and thin-layer starch gel (TLS) electrophoretic techniques. Malate dehydrogenase (MDH) after electrophoresis on CA or TLS and mannose phosphate isomerase (MPI) on TLS were the only enzymes of 13 examined which discriminated between the organisms from patients with uta (L. (V.) peruviana) and those with sylvatic leishmaniasis (L. (V.) braziliensis). Mannose phosphate isomerase gave more clear-cut and reproducible discrimination than did MDH on either TLS or CA, and it is suggested that MPI is a reliable enzyme marker that can be used in routine TLS electrophoresis to distinguish between L. (V.) peruviana and L. (V). braziliensis.
Organic Liquid Scintillators. VI. Substituted Distyrylbenzenes: Scintillation Properties and Spectra of Absorption and Fluorescence (1964)

The preparation, spectra of absorption and fluorescence, and the scintillation properties of 28 derivatives of trans,trans-p-distyrylbenzene are described. Most of the soluble derivatives are efficient primary scintillators in alkylbenzene solutions and are highly efficient secondary scintillators in alkylbenzene solution of p-terphenyl. Solutions with efficiencies exceeding those of the best-reported liquid scintillation systems are described.
Self-limiting of the thickness of diamond-like films deposited in the laser pyrolysis of liquid aromatic hydrocarbons (2000)

The process involving the self-regulation of the thickness of a diamond-like film, deposited on the interface between a transparent dielectric substrate (glass, sapphire, quartz) when a liquid aromatic hydrocarbon is heated by the radiation of a copper vapour laser, was observed and investigated. The film thickness reaches 100 nm and ceases to depend on the number of laser pulses, whereas the depth of the ablated region of the substrate, in which the film is deposited, increases monotonically. The self-regulation effect, observed over a wide range of pressures (from 0.08 to 10 bar), is caused both by the heating of the deposited film by the laser radiation to the graphitisation temperature and by its mechanical damage as a consequence of the difference between the coefficients of thermal expansion of the film and the substrate. The latter has been confirmed with the aid of x-ray Auger spectroscopy, the results of which indicate the formation in the liquid of a nanodisperse suspension of carbon particles with the diamond type of bonding.
Activation hors site des catalyseurs d'hydrotraitement (1996)

Le procede sulficat est le nom commercial donne par la societe eurecat a un procede ex-situ de sulfuration prealable. Il consiste a impregner les precurseurs oxydes de catalyseurs d'hydrotraitement par des polysulfures organiques de haut poids moleculaire. Apres un traitement thermique a basse temperature sous atmosphere controlee, le solide est charge dans l'unite d'hydrotraitement. La sulfuration de ce catalyseur est obtenu sous pression d'hydrogene, en presence ou non de la charge a hydrotraiter, par augmentation de la temperature sans ajout ulterieur de composes soufres. L'objectif de ce travail est la caracterisation physico-chimique des solides impregnes et actives sous pression d'hydrogene. Pour mener a bien cette etude, un reacteur de thermoreduction pouvant travailler sous des pressions d'hydrogene comprises entre 0,1 et 5 mpa a ete mis au point. Cette realisation a necessite une etude approfondie de l'hydrodynamique afin de compenser les effets de retard lies a la distribution des temps de sejour des reactifs. L'emploi de diverses techniques de caracterisation a permis de montrer qu'a l'issu du traitement sulficat, les interactions entre la phase oxyde (moo#3 et coo) et le polysulfure etaient suffisamment fortes pour induire une reduction partielle des oxydes et du soufre au benefice d'une oxydation des groupements alkyles voisins. La pression d'hydrogene accroit uniquement la vitesse de decomposition des especes thioorganiques chimisorbees et permet de diminuer la temperature de sulfuration. La dispersion de la phase active (mos#2) est ainsi plus elevee ce qui induit une plus grande activite catalytique
Improved decision directed carrier phase estimation for nonlinearity mitigation in 16-QAM systems (2014)

We propose and numerically investigate an improved decision directed (IDD) carrier phase estimation (CPE) to mitigate fiber nonlinearity in 16 quadrature amplitude modulation (QAM) coherent transmission systems. The proposed IDD-CPE algorithm is derived based on a two stage approach and compared with other CPE algorithms namely, the pre-decision directed (PDD) CPE and the decision directed (DD) phase locked loop (PLL). By exploiting the symbol position information in the I-Q plane and a euclidean distance measure, the proposed IDD-CPE algorithm outperforms the PDD-CPE and DD-PLL methods, exhibiting an optimal performance at signal launch power of 0 dBm and at optical signal to noise ratios (OSNRs) greater than 28dB, where no bit errors are detected.
Handheld hyperspectral imager for standoff detection of chemical and biological aerosols (2004)

Pacific Advanced Technology has developed a small hand held imaging spectrometer, Sherlock, for gas leak and aerosol detection and imaging. The system is based on a patent technique that uses diffractive optics and image processing algorithms to detect spectral information about objects in the scene of the camera (IMSS Image Multi-spectral Sensing). This camera has been tested at Dugway Proving Ground and Dstl Porton Down facility looking at Chemical and Biological agent simulants. The camera has been used to investigate surfaces contaminated with chemical agent simulants. In addition to Chemical and Biological detection the camera has been used for environmental monitoring of green house gases and is currently undergoing extensive laboratory and field testing by the Gas Technology Institute, British Petroleum and Shell Oil for applications for gas leak detection and repair. The camera contains an embedded Power PC and a real time image processor for performing image processing algorithms to assist in the detection and identification of gas phase species in real time. In this paper we will present an over view of the technology and show how it has performed for different applications, such as gas leak detection, surface contamination, remote sensing and surveillance applications. In addition a sampling of the results form TRE field testing at Dugway in July of 2002 and Dstl at Porton Down in September of 2002 will be given.
SRAM cells for low-power write in buffer memories (2002)

We present a novel approach to SRAM cell operation for low-power write. Instead of providing read stability by using much stronger inverter than access transistors, we do so by using a lower word-line voltage during read. Thus, the cell can be written to with low bit-line voltage swing, thereby significantly reducing the energy required to write.
Victorinus Bythner (1938)

Victorinus Bythner Get access Jan Mazerski, D.D. Jan Mazerski, D.D. 1Salesian House, Cowley, Oxford Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 175, Issue 8, 20 August 1938, Page 135, https://doi.org/10.1093/nq/175.8.135f Published: 20 August 1938
Experimental Carotid Aneurysms: I. Simple Surgical Production and Radiographic Evaluation (1977)

Using simple surgical techniques, experimental carotid aneurysms are created which simulate some types of human berry aneurysms, both in hemodynamic and radiographic behavior. End to side anastomoses of an external jugular vein graft to the common carotid artery can be carried out by radiologic personnel with no formal surgical training. Factors which cause the aneurysms to fail and fill with clot are infection, incorporation of venous valves into the aneurysm sac, poor suturing technique, and perhaps a sac too large in comparison with its neck. The models are studied and followed by percutaneous catheter angiography, and show the swirling flow seen in clinical practice. These models may be used to study and refine percutaneous catheter occlusive techniques.
Observing an induced fit mechanism during sequence specific DNA methylation (2006)

Induced fit mechanisms rely on conformational changes that have been evoked by enzymes to facilitate a variety of processes which assist in catalysis. When the DNA cytosine C5 methyltransferase M. HhaI binds cognate DNA, a loop of 20 amino acids (80–100) makes a large 26 Å movement into the minor groove of the DNA with concomitant extrusion of the target cytosine, or baseflipping. The loop is seen in the open conformation in the AdoHcy/non-cognate DNA structure and in the closed conformation in the AdoHcy/cognate DNA structure. To observe this conformational switch by fluorescence we engineered novel tryptophans into the loop to replace K91 and E94. To better observe the differential quenching between loop conformers for K91W and E94W, the lone native tryptophan in M. HhaI (W41F) was removed. The double mutant W41F/E94W has minimal differences in kinetic and thermodynamic properties from WT. We observed a large change in W41F/E94W fluorescence by steady state and stopped-flow upon cognate DNA addition which was not observed with non-specific DNA or cofactor additions. This suggests the enzyme binds tightly to DNA at the cognate site by repositioning the loop. We also show loop motion is coupled to baseflipping and specificity. Our solution based results provide a mechanism whereby the induced-fit process related to sequence recognition is coupled to a conformational transition within the enzyme. Funding provided by the UC GREAT grant.
Binaural reproduction of spherical microphone array signals. (2009)

An efficient method for the production of binaural audio signals from spherical microphone array signals using head related impulse responses (HRIRs) is presented. The processing is done directly in the spherical Fourier transform domain which offers significant speed advantages over the conventional method of beamforming toward each HRIR measurement point. The encoding of HRIRs into the spherical Fourier domain is complicated by the fact that the available HRIR databases (CIPIC, MIT, KEMAR) use irregular sampling positions around the sphere and do not contain data for sound coming from angles below the subject. However, for spatially bandlimited processing it is possible to use an LMS technique with regularization to perform the spherical Fourier transform of these HRIRs. A real-time system with head-tracking using the eigenmike (TM) and the CIPIC HRIR database is presented which processes spherical harmonics up to third order. Since the head-rotation operation is performed digitally, this technique is especially useful for remote surveillance and virtual reality systems with complex acoustic scenes.
Cr-doped GaAs/AlGaAs semi-insulating multiple quantum well photorefractive devices (1993)

Semi-insulating multiple quantum well photorefractive devices using GaAs/Al0.29Ga0.71As with an electric field applied perpendicular to the layers are demonstrated. Semi-insulating behavior is obtained by doping with Cr(1016/cm3) during epitaxial growth of the material. Diffraction efficiencies as high as 3% with an applied voltage of 20 V and microsecond response times are obtained in a 2 μm thick device. These devices are of importance for implementation of fast and sensitive two-dimensional optical information processing systems at wavelengths compatible with current diode lasers without the spatial-bandwidth limitations of thick photorefractive materials.
Pulmonary Hypertension in a Patient with Essential Thrombocythemia (2003)

A 67-year-old woman with essential thrombocythemia (ET) developed acute heart failure and marked pulmonary hypertension (PH). No clear cause for the PH could be initially found. We suspected that thrombocytosis might cause PH. Treatments with anticoagulant (heparin and warfarin), platelet-lowering (hydroxyurea), and antiplatelet (ticlopidine) agents resulted in improvement of the clinical, hemodynamic conditions, and the control of platelet counts. We found that the main etiology of PH in the present case might be the pulmonary capillary obstruction from local pulmonary microthrombosis complicated with ET. Although PH associated with ET is uncommon, it should be always considered as a possible cause of dyspnea in patients with ET.
ChemInform Abstract: Highly Asymmetric Diels‐Alder Cycloaddition of Menthyl Z‐(S)s‐3‐(2‐Pyridylsulfinyl)propenoate with Cyclohexa‐1,3‐diene. (1989)

Abstract Lewis acid‐promoted cycloaddition reaction of the optically active sulfinylpropenoate (II) with cyclohexa‐1,3‐diene (I) gives only the endo‐bicyclo(2.2.2)octenecarboxylate (III).
Pheochromocytoma supplied by the dorsal pancreatic artery (1985)

Pheochromocytoma supplied by the dorsal pancreatic arteryDL Miller, JL Doppman, GL Andriole, MW Linehan and HR KeiserAudio Available | Share
Altered Expression of <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> in Predisposition to Hereditary Nonpolyposis Colorectal Cancer (2003)

Our expression-based strategy stratified the present "mutation-negative" cohort into two discrete categories: families linked to the major MMR genes MLH1, MSH2, and MSH6 (11 [42%] of 26) and those likely to be associated with other, as yet unknown susceptibility genes (15 [58%] of 26).
An isolable β-diketiminato chlorosilylene (2018)

The first β-diketiminate ligated chlorosilylene has been synthesised and isolated from the corresponding β-diketiminato dichlorohydrosilane through dehydrochlorination with an N-heterocyclic carbene.
The Role of NAG-1/GDF15 in the Inhibition of Intestinal Polyps in <i>APC</i>/<i>Min</i> Mice by Sulindac (2011)

The antitumor effects of nonsteroidal anti-inflammatory drugs (NSAID) are assumed to be due to the inhibition of COX activity, but COX-independent mechanisms may also play an important role. NSAID-activated gene (NAG-1/GDF15) is induced by NSAIDs and has antitumorigenic activities. To determine the contribution of COX-2 inhibition and NAG-1/GDF15 expression to the prevention of colon carcinogenesis by NSAIDs, we evaluated several sulindac derivatives [des-methyl (DM)-sulindac sulfide and its prodrug DM-sulindac] that do not inhibit COX-2 activity. Sulindac sulfide and DM-sulindac induced the expression of NAG-1/GDF15 in HCT116 cells as determined by quantitative real-time PCR and Western blot. We fed APC/Min mice with 320 ppm of sulindac and doses of DM-sulindac. Only sulindac significantly inhibited tumor formation inAPC/Min mice. To determine the pharmacokinetic properties of sulindac and DM-sulindac in vivo, wild-type C57/B6 mice were fed with sulindac and DM-sulindac at 80, 160, and 320 ppm. High-performance liquid chromatography analysis revealed that the conversion of DM-sulindac to DM-sulindac sulfide (active form) was less efficient than the conversion of sulindac to sulindac sulfide (active form) in the mice. Lower levels of DM-sulindac sulfide accumulated in intestinal and colon tissues in comparison with sulindac sulfide. In addition, NAG-1/GDF15 was induced in the liver of sulindac-fed mice but not in the DM-sulindac-fed mice. Collectively, our results suggest that the tumor-inhibitory effects of sulindac in APC/Min mice may be due to, in part, NAG-1/GDF15 induction in the liver. Our study also suggests that pharmacologic properties should be carefully evaluated when developing drug candidates.
Much without touch—Conditions for surface enhanced infrared absorption (1998)

Optical properties of metal-insulator composite materials are discussed with respect to the effect called ‘surface enhanced infrared absorption (SEIRA)’. After an introductory discussion of the electric interaction of polarizable particles the Bergman representation is discussed as the basis of effective medium theories. It is applied to describe experimental spectra and leads directly to the SEIRA effect. Finally we suggest what kind of systems should be prepared to obtain efficient absorption enhancement.
Platinierungsmechanismen für Reaktionen von Cisplatin mit GG‐Einzelstrang‐ und ‐Doppelstrang‐Decanucleotiden (1995)

Die 1 H, 15 N‐korrelierte NMR‐Spektroskopie ist die Methode der Wahl, um die Reaktion des Antitumormittels Cisplatin cis ‐[PtCl 2 (NH 3 ) 2 ] 1 mit DNA zu untersuchen. Bei Umsetzungen von 1 mit komplementären Modell‐Oligonucleotiden lassen sich mit dieser Methode alle Zwischenstufen nachweisen; eines dieser Intermediate ist oben gezeigt. magnified image
Persistent thyroid autoimmunity after subacute thyroiditis. (1987)

Subacute (de Quervain's) thyroiditis (SAT) is accompanied by temporary abnormalities in thyroid function and, in a minority of patients, by transient thyroglobulin and thyroid microsome autoantibody formation. In this report we have examined the sera of patients with SAT for the presence of multiple thyroid autoantibodies using qualitative immunoblotting (Western blotting). For this purpose we used a crude thyroid extract (2,000 g supernatant) as a source of antigen, in order to identify antibodies reacting with a wide range of potential autoantibodies. Eight of the 9 patients tested had autoantibodies which reacted with between 2-18 antigenic determinants (molecular weights 177-10 kd) present in the thyroid antigen preparation. None of the sera reacted with thyroglobulin or thyroid microsomes. The majority of these autoantibodies were directed against antigens which were absent from liver membrane preparations. Furthermore there was no diminution in the levels of these autoantibodies over a period of up to 39 months after the onset of SAT. The prolonged presence of these novel thyroid autoantibodies may explain the recent findings of subtle thyroid defects, such as altered gland iodine content, long after apparent clinical resolution of SAT. The accumulated evidence for a viral aetiology in this condition suggests that these sequelae may be due to a virally-induced autoimmune response.
Effect of continuous pressure on histopathological changes in denture‐supporting tissues (1997)

The histopathological changes in denture-supporting tissues were studied in relation to continuous pressure exerted through an experimental denture base. The experimental dentures were designed to load continuous pressures (1.5, 3.4 or 4.9 kPa) to the palate of molar region of rat. Histopathological changes caused by the continuous pressure were observed, and the intensity of the pressure was also estimated. A high correlation was observed between the histopathological changes under the denture base and the intensity of the continuous pressure. In groups exposed to 4.9 and 3.4 kPa, the continuous mechanical pressure caused bone resorption; in 1.5 kPa group, no evidence of bone resorption was observed. The epithelium and lamina propria mucosa under the denture base, which were compressed by the continuous pressure, recovered histopathologically depending on the decrease of the pressure caused by bone resorption; no quantitative recovery of the absorbed bone tissue was observed. No inflammatory change was induced by the continuous pressure. From the histopathological results observed in this study, the possibility of the existence of a threshold for bone resorption induced by continuous pressure was suggested.
HER-3 peptide vaccines/mimics: Combined therapy with IGF-1R, HER-2, and HER-1 peptides induces synergistic antitumor effects against breast and pancreatic cancer cells (2014)

The human epidermal growth factor receptor 3 (HER-3/ErbB3) is a unique member of the human epidermal growth factor family of receptors, because it lacks intrinsic kinase activity and ability to heterodimerize with other members. HER-3 is frequently upregulated in cancers with epidermal growth factor receptor (EGFR/HER-1/ErbB1) or human epidermal growth factor receptor 2 (HER-2/ErBB2) overexpression, and targeting HER-3 may provide a route for overcoming resistance to agents that target EGFR or HER-2. We have previously developed vaccines and peptide mimics for HER-1, HER-2 and vascular endothelial growth factor (VEGF). In this study, we extend our studies by identifying and evaluating novel HER-3 peptide epitopes encompassing residues 99-122, 140-162, 237-269 and 461-479 of the HER-3 extracellular domain as putative B-cell epitopes for active immunotherapy against HER-3 positive cancers. We show that the HER-3 vaccine antibodies and HER-3 peptide mimics induced antitumor responses: inhibition of cancer cell proliferation, inhibition of receptor phosphorylation, induction of apoptosis and antibody dependent cellular cytotoxicity (ADCC). Two of the HER-3 epitopes 237-269 (domain II) and 461-479 (domain III) significantly inhibited growth of xenografts originating from both pancreatic (BxPC3) and breast (JIMT-1) cancers. Combined therapy of HER-3 (461-471) epitope with HER-2 (266-296), HER-2 (597-626), HER-1 (418-435) and insulin-like growth factor receptor type I (IGF-1R) (56-81) vaccine antibodies and peptide mimics show enhanced antitumor effects in breast and pancreatic cancer cells. This study establishes the hypothesis that combination immunotherapy targeting different signal transduction pathways can provide effective antitumor immunity and long-term control of HER-1 and HER-2 overexpressing cancers.
Purification and properties of the lipase from<i>Candida deformans</i> (zach) langeron and guerra (1985)

Abstract Palm oil being solid at room temperature could be converted into a fluid oil by substitution of about 40–50% of its palmitic acid. This could be achieved by a fermentation process or using yeast lipase. Candida deformans CBS 2071 seemed suitable for this purpose: therefore, its lipase was isolated and studied. This enzyme was purified by acetone precipitation followed by chromatographies on Sephadex C 50 and Sephadex G 150. The purification factor achieved was ×70, and the protein and activity yields were 0.25% and 18%, respectively. The homogeneity of the purified enzyme was verified by polyacrylamide gel electrophoresis. The enzyme molecular weight was estimated at 207,000. Its activity is optimal between 40 C and 50 C and its optimum pH is 7.0. This enzyme is thermo‐resistant and loses only 14% and 18% of its activity, respectively, when heated to 45 C and 55 C for 30 min. Its activation energy was 2.75 kcal.mole −1 and its inactivation energy was around 21 kcal.mole −1 . This enzyme is activated by Ca ++ , Mg ++ and Co ++ and inhibited by Cu ++ , Zn ++ , and p‐chloromercuribenzoate (pCMB) and EDTA. The synthesis of this lipase is induced by lipid substrates in the culture medium and inhibited by glucose. This enzyme attacks primarily the 1‐ (or 3‐) position of all triglycerides tested. Hydrolysis was preferential for triglycerides containing short chain fatty acids. The triglycerides with monounsaturated monoacids were more quickly hydrolyzed, than those with saturated monoacids. The presence of two and especially three double bonds in the fatty acid chain seemed to slow down the rate of hydrolysis.