gebhart/patrepeval huggingface dataset:
Establishment of a Rodent Model of HIV-Associated Sensory Neuropathy (2006)

Human immunodeficiency virus (HIV)-associated sensory neuropathy (SN) is the most common neurological complication of HIV infection in the current highly active antiretroviral therapy era. The painful sensory neuropathy is associated with the use of dideoxynucleoside antiretrovirals, and its development limits the choice of antiretroviral drugs in affected patients. There are presently no effective therapies for HIV-SN, and moreover there has been no robust animal model of HIV-SN in which candidate therapeutic agents can be tested. In this paper, we show that we have established a rodent model of HIV-SN by oral administration of a dideoxynucleoside drug, didanosine, to transgenic mice expressing the HIV coat protein gp120 under a GFAP promoter. The neuropathy in these rodents is characterized by distal degeneration of unmyelinated sensory axons, similar to the "dying back" pattern of C-fiber loss seen in patients with HIV-SN. This model will be useful in examining mechanisms of distal axonal degeneration and testing potential neuroprotective compounds that may prevent development of the sensory neuropathy.
Novel algorithm for transcriptome analysis (2006)

A growing body of evidence implicates the oocyte as a key regulator of ovarian folliculogenesis and early embryonic development. We have screened bovine cDNA microarrays (containing expressed sequence tags representing >15,000 unique genes) with Cy3- and Cy5-labeled cDNA derived from bovine oocyte samples collected at two different stages of meiotic maturation (germinal vesicle vs. metaphase II; n = 3 samples per group). Here, we present a novel data analysis approach that uses all available information from above experiments to obtain and index the transcriptome of bovine oocytes and changes in transcriptome composition in response to meiotic maturation. Signal intensities (Fg) for all housekeeping genes were omitted prior to analysis. A local threshold for gene expression was computed as background intensity (Bg) plus 2 times the standard deviation of background and foreground signals. Within each array, data were normalized by the LOWESS procedure. Subsequently, a two-stage mixed model was fitted to remove systematic variations. In the first stage, the response was the LOWESS normalized Fg with treatment as a fixed effect. In stage 2, the residuals from stage 1 were analyzed in a gene-specific model that included treatment group and spots nested within patch and array. A test for the difference between least squares means for the treatment effect was performed. A false discovery rate (FDR) adjustment on the p values for the difference was carried out. This novel algorithm was compared with approaches that ignore the FDR and the threshold described herein and stark differences obtained.
Cyclic guanidines. I. Synthesis of hypoglycemic 1-substituted 2-imino-1,3-diazacycloalkanes. (1978)

Reaction of 2-benzylaminoethylamine (1a) with cyanogen bromide was investigated under various conditions to obtain desired 1-benzyl-2-iminoimidazolidine (2a) in quantitative yield. In addition, in the presence of base this reaction gave 3-carbamoyl derivative (3a) or 3-methoxyformimidoyl derivative (6) of 2a. The 3-carbamoyl group of 3a was rearranged to the 2-imino group on heating to give 2-carbamoylimino derivative (5a). On the other hand, 6 was derived to 3a or 3-methoxycarbonyl derivative (7) by heating under strong or mild acidic medium, respectively. 3-Amidino-1-benzyl-2-iminoimidazolidine (9) was prepared through 2-benzylaminoethylguanidine (8) from 1a. 1-Benzyl- or 1-benzhydryl-2-cyanoimino-1, 3-diazacycloalkanes (10) having five-, six- and seven-membered ring size were obtained on heating of 1 with dimethyl cyanoimidodithiocarbonate and then the cyano group of 10 was selectively removed to yield 1-benzyl- or 1-benzhydryl-2-imino-1, 3-diazacycloalkanes (2). Some of 1-substituted 2-imino-1, 3-diazacycloalkane derivatives showed hypoglycemic activity.
Design of an experimental setup for hydro-kinetic energy conversion (2009)

A hydro-kinetic energy project has been underway in Sweden since 2000, and an in-stream prototype setup for experiments at a site in a Swedish river is now in progress. The system comprises a vertical axis turbine and a directly driven permanent magnet generator. Methods and choices used in designing the system are described here. The turbine and generator are evaluated based on measurements and CFD simulations of conditions at the site for the experimental setup.
Pharmacokinetic properties of the tocolytic agent [Mpa<sup>1</sup><scp>d</scp>‐Tyr(Et)<sup>2</sup>, Thr<sup>4</sup>, Orn<sup>8</sup>]‐oxytocin (antocin) in healthy volunteers (1993)

Summary OBJECTIVE The aim of this study was to study the pharmacokinetics of antocin, the tocolytic oxytocin antagonist [Mpa 1 d ‐Tyr 2 (Et), Thr 4 , Orn 8 ]‐oxytocin. DESIGN Antocin was injected intravenously as a bolus dose (5 μ mol ). Blood samples were taken at intervals for 240 minutes. In addition, the binding of 125 I‐Tyr 10 ‐antocin to blood constituents was determined and compared with 125 I‐AVP and 125 I‐[Mpa ‐1 d ‐Arg 8 ]‐vasopressin (desmopressin). SUBJECTS Eight healthy, non‐smoking adults, three male and five female. MEASUREMENTS Antocin was measured using a specific radioimmunoassay after prior extraction of the plasma. Plasma binding was estimated using polyethyleneglycol precipitation. RESULTS The rate of plasma disappearance of antocin was best fitted by a biexponential curve. The clearance of antocin was 23.5 ± 7–6 I/h, the volume of distribution was 13.1 ± 3.8 I and the biological half‐life was 39.0 ± 4.1 minutes, A greater proportion of 125 l‐Tyr , 10 ‐antocin bound to plasma proteins (33.5%) and red blood cells (13%) than did 125 I‐AVP, 125 l‐desmopressin and unlabelled desmopressin. CONCLUSIONS The half‐life was longer and the clearance of antocin was less than that found in a previous study when a non‐specific antiserum was used. This is most likely because of the extended blood sampling time period which revealed the biphasic decay pattern. The higher plasma clearance of antocin compared to oxytocin and desmopressin may be explained by its increased binding to blood constituents rather than by differences in enzymatic degradation of the molecules.
A Case of Ollierʼs Disease Associated with Two Intracranial Gliomas (1987)

Ollier's disease or multiple enchondromatosis is a deforming dysplastic disease of cartilage involving primarily the metaphyses and diaphyses of long bones. It is only rarely associated with sarcomatous degeneration of the enchondromas or other generalized neoplasms. A related disease, Maffucci's syndrome, is, however, associated with generalized tumors. We present the case of a 29-year-old, albino, black man with Ollier's disease who, as a child, underwent a number of orthopedic procedures for multiple limb deformities and fractures. At age 25, he developed hydrocephalus, progressive cranial nerve palsies, and a large enchondroma of the skull base. He subsequently underwent multiple shunt procedures and two suboccipital craniectomies. Eighteen months later, a brain computed tomographic (CT) scan revealed an intracerebellar mass, which was found to be an anaplastic astrocytoma. Two years later, he developed a right hemiparesis and sensory dysfunction with a diffuse supratentorial mass on CT scan. A stereotactic biopsy showed this to be a similar anaplastic astrocytoma. The literature concerning Ollier's disease is reviewed, and the intracerebral lesions associated with both Ollier's disease and Maffucci's syndrome are examined.
Interfacial Molecular Recognition. Binding of Ferrocenecarboxylate to β-Aminocyclodextrin Hosts Electrostatically Immobilized on a Thioctic Acid Monolayer (1998)

The interfacial binding properties of electrodes prepared by the electrostatic immobilization of an adlayer of positively charged β-aminocyclodextrin (β-ACD) hosts on a self-assembled monolayer of thioctic acid on gold were investigated using Osteryoung square wave voltammetry. The results indicate that the water-soluble ferrocenecarboxylate (Fc-COO-) guest was effectively bound by the interfacial β-ACD hosts, with binding constants in the range (2−5) × 104 M-1. The measured binding constants were found to increase slightly with the surface density of immobilized hosts.
Deployment of an alternative cover and final closure of the Mixed Waste Landfill, Sandia National Laboratories, Albuquerque, New Mexico. (2003)

An alternative cover design consisting of a monolithic layer of native soil is proposed as the closure path for the Mixed Waste Landfill at Sandia National Laboratories, New Mexico. The proposed design would rely upon soil thickness and evapotranspiration to provide long-term performance and stability, and would be inexpensive to build and maintain. The proposed design is a 3-ft-thick, vegetated soil cover. The alternative cover meets the intent of RCRA Subtitle C regulations in that: (a) water migration through the cover is minimized; (b) maintenance is minimized by using a monolithic soil layer; (c) cover erosion is minimized by using erosion control measures; (d) subsidence is accommodated by using a ''soft'' design; and (e) the permeability of the cover is less than or equal to that of natural subsurface soil present. Performance of the proposed cover is integrated with natural site conditions, producing a ''system performance'' that will ensure that the cover is protective of human health and the environment. Natural site conditions that will produce a system performance include: (a) extremely low precipitation and high potential evapotranspiration; (b) negligible recharge to groundwater; (c) an extensive vadose zone; (d) groundwater approximately 500 ft below the surface; and (e) a versatile, native flora that will persist indefinitely as a climax ecological community with little or no maintenance.
[Recurrence of Waldenström macroglobulinemia accompanied by factor X deficiency]. (2016)

A medical check-up revealed severe anemia in an 85-year-old man who had been diagnosed with Waldenström macroglobulinemia 11 years previously. On the other hand, prolonged PT and aPTT were demonstrated on admission, and were attributed to a significant decrease in factor X activity. These abnormalities were all considered to be have been caused by an exacerbation of the underlying disease and, thus, chemotherapy with the RCD regimen (rituximab, cyclophosphamide, dexamethasone) was started. No significant improvement was obtained and the patient died suddenly on day 154. AL amyloidosis was diagnosed by histopathological examinations and also confirmed by a sequence analysis of amyloid protein. This case with Waldenström macroglobulinemia complicated by AL amyloidosis and recurrent factor X deficiency is quite rare.
Nutraceutical and Cosmeceutical Potential of Seaweed Derived Fucoxanthin (2021)

The marine ecosystem is considered a potentially mysterious reservoir of biodiversity consisting of a broad spectrum of bioactive constituents, whose potential is still under research for pharmaceuticals, nutraceuticals and cosmeceuticals. Fucoxanthin, a carotenoid, can be found in the brown seaweeds and is recognized to show promising and exclusive biological activities. Subsequent consumption and absorption of fucoxanthin leads to its accumulation in the white adipose tissue and helps to depict anti-obesity effects via upregulation of thermogenesis through uncoupling protein 1 expression and mitochondrial activation. Linking with anti-obesity, fucoxanthin shows antidiabetic potential by insulin resistance signalling pathways. Fucoxanthin is also reported to control carcinogenesis via regulating several biomolecules and signalling pathways which are intermittently linked with either apoptosis or cell cycle arrest or suppression of metastasis. In addition, it can act as a potential antioxidant by scavenging toxic free radicals and also aid in the treatment of neurodegenerative, hepatic and cardiovascular dysfunctions. Fucoxanthin has a profound role in the cosmetic industry for its mosquito repellent activity and protective effects on the blood vessels, skin and bones. Therefore, the current review provides the recent available scientific literature on Fucoxanthin regarding its health-promoting effects, modulating mechanism and future potential to use it as a commercially viable drug in nutraceutical and cosmeceutical applications.https://sekabet.fun/https://asyabahis.fun/https://asyabahis.xyz/https://tipobet.fun/https://olabahis.fun/https://betist.fun/
Increased Skin Tumor Incidence and Keratinocyte Hyper-Proliferation in a Mouse Model of Down Syndrome (2016)

Down syndrome (DS) is a genetic disorder caused by the presence of an extra copy of human chromosome 21 (Hsa21). People with DS display multiple clinical traits as a result of the dosage imbalance of several hundred genes. While many outcomes of trisomy are deleterious, epidemiological studies have shown a significant risk reduction for most solid tumors in DS. Reduced tumor incidence has also been demonstrated in functional studies using trisomic DS mouse models. Therefore, it was interesting to find that Ts1Rhr trisomic mice developed more papillomas than did their euploid littermates in a DMBA-TPA chemical carcinogenesis paradigm. Papillomas in Ts1Rhr mice also proliferated faster. The increased proliferation was likely caused by a stronger response of trisomy to TPA induction. Treatment with TPA caused hyperkeratosis to a greater degree in Ts1Rhr mice than in euploid, reminiscent of hyperkeratosis seen in people with DS. Cultured trisomic keratinocytes also showed increased TPA-induced proliferation compared to euploid controls. These outcomes suggest that altered gene expression in trisomy could elevate a proliferation signalling pathway. Gene expression analysis of cultured keratinocytes revealed upregulation of several trisomic and disomic genes may contribute to this hyperproliferation. The contributions of these genes to hyper-proliferation were further validated in a siRNA knockdown experiment. The unexpected findings reported here add a new aspect to our understanding of tumorigenesis with clinical implications for DS and demonstrates the complexity of the tumor repression phenotype in this frequent condition.
Discrete Probability Models with Modified Zeros (1978)

Two types of discrete probability models are investigated. The models arise from the Poisson process by modifying in certain ways the probability of observing a zero. The first type is a composite of two discrete pdf's to allow for adjustment in the probability of observing no occurrences of the event of interest. The second is a pure birth process in which the transition intensity changes after the first event of interest has occurred. Procedures for estimating the parameters of these models are given. The models fit well the actual data selected from reliability and queuing applications.
Design and performance of a normal-incidence optical critical dimension metrology system (2002)

Summary form only given. A new microscope-based spectrometric instrument has been designed for measuring the critical dimensions of dense line and space targets on patterned silicon wafers. The repeating structure of the target behaves as a one dimensional diffraction grating. Light, focussed at normal incidence on the wafer, is diffracted symmetrically into positive and negative orders with the O/sup th/ order beam being reflected back through the objective lens. The arrangement of the optics prevents all but the O/sup th/ order beam from being collected for detection. At normal incidence, the beam is a superposition of two linearly polarized components with some phase difference, /spl Delta/. Light polarized in the direction of the grating lines is called TE polarized light, and light polarized perpendicular to the lines is called TM polarized light. Any or all of three spectra can be measured: (1) TE reflectance, (2) TM reflectance, (3) phase difference. Measurement results from both photolithography and etch applications are presented.
Plasma Marking of Arctic Foxes with lophenoxic Acid (1987)

Six arctic foxes (Alopex lagopus) were marked with iophenoxic acid (IA), a substance which elevates concentrations of protein-bound iodine in blood plasma. Buccal absorption of IA was determined by placing 20 mg IA dissolved in 100% ethyl alcohol on the tongue. Blood samples collected from 1 to 36 wk following exposure showed that all foxes were marked already at 1 wk and continued until 13 wk; two foxes were still marked at 36 wk. Clearance rates for iodine varied with initial dose response, and those foxes with high 1-wk iodine concentrations excreted iodine more rapidly than those with lower initial concentrations; by 13-wk excretion rates were similar.
Effect of reserpine on choline acetyltransferase and high affinity choline uptake in the rat brain [proceedings]. (1977)

<p>The design of an energy-efficient memory subsystem is one of the key issues that system architects face today. To achieve this goal, architects usually rely on system simulators and trace-based DRAM power models. However, their long execution time makes the approach infeasible for the design-space exploration of next-generation exascale computing systems. Analytic models, in contrast, are orders of magnitude faster. In this paper, we propose a new analytic memory-scheduler-agnostic power model for DRAM, henceforth referred to as MeSAP. Similarly to state-of-the-art trace-based approaches, our analytic model achieves an average error of 20%, while being an order of magnitude faster. Furthermore, we integrate MeSAP into an analytic performance model of general-purpose processors and show its applicability to the design of a computing system targeting scientific image processing applications.</p>
Atmospheres of White Dwarfs (1962)

Abstract Atmospheres of white dwarfs are treated with hydrogen poor chemical composition. It is shown that colors of some white dwarfs fit very well with the calculated values. It is also suggested that there are two types of white dwarfs that differ in their chemical composition and are different in size to each other.
Biosensors and other medical and environmental probes (1996)

The author presents a overview of work at Oak Ridge National Laboratory directed toward the development of biosensors which can be used to monitor for an array of medical and environmental effects. The article describes the variety of problems which have been addressed by development of such sensors, and the range of staff who have been actively involved in this effort. The first such sensor developed at ORNL was an optical fiber whose end was treated with an antibody which would react with the carcinogen benzo(a)pyrene (BaP). Section titles from the article provide an idea of the breadth of applications addressed: medical telesensors; microcantilevers; detecting cancer and health abnormalities; bioreporters; miniaturized devices; biosensors and DNA analysis; lipids in bacteria and human fingerprints; and anthropometry.
Images reconstruction using modified exemplar based method (2011)

This paper describes a novel image reconstruction method based on modified exemplar based technique. This modification allows to choose sub-optimally image-adaptive form and size of the block in order to find similar patches, number of which is further increased by rotation of these blocks. We show that the efficiency of image reconstruction depends on the choice of block size for the exemplar based method. Proposed block size selection adaptivity allows to obtain a smaller reconstruction error than that of the traditional method as well as other state-of-the-art image inpainting methods. We demonstrate the performance of a new approach via several examples, showing the effectiveness of the proposed algorithm in removal of small and large objects on the test images.
Model order reduction for stochastic nonlinear systems (2017)

The problem of model reduction for stochastic nonlinear systems is addressed with the moment matching method. We characterize the steady-state of nonlinear stochastic systems exploiting a stochastic version of the center manifold theorem. Exploiting the steady-state response we formulate the notion of moment for stochastic nonlinear systems and we solve the problem of model reduction proposing a family of nonlinear stochastic reduced order models. Moreover, we formulate also the notion of nonlinear stochastic reduced order model in the mean. The advantage of this last family of stochastic models is that the complexity of their determination is equal to the complexity of the determination of deterministic reduced order models. The relation between the two families of reduced order models is illustrated by means of a simple example based on an electrical circuit.
Local Anesthetic Systemic Toxicity (2010)

The most feared complication associated with the administration of local anesthetics is the profound and potentially lethal effect that these agents can have on cardiac conduction and function. This review traces the evolution of local anesthetic systemic toxicity beginning with the early deaths associated with the introduction of cocaine into clinical practice. The development of bupivacaine is discussed, with particular emphasis on the delayed recognition and acceptance of its inherent cardiotoxicity. Finally, the origins of lipid resuscitation are reviewed with respect to their theoretical foundation, as well as the confluence of events and experimental investigations that delivered this therapy into clinical practice.
Mössbauer relaxation line shapes in the presence of complex hyperfine interactions (1976)

We have utilized a result of Clauser to evaluate the line shape of M\"ossbauer resonance spectra involving spin relaxation effects even in cases with nondiagonal hyperfine interactions. Compared to traditional methods for calculating the line shapes, this formulation saves computational time by approximately two orders of magnitude and thus makes possible consideration of many problems which were previously intractable. Examples are given for cases involving complicated hyperfine Hamiltonians, viz., hemoglobin cyanide, acid met myoglobin, and Np${\mathrm{F}}_{6}$.
LEAD IODIDE NUCLEAR PARTICLE DETECTORS (1971)

Semiconductor nuclear particle detectors have been made from lead iodide. α particles and γ quanta have been counted in the temperature range from −200 to +130°C. From α-particle pulse height the μτ+ product has been estimated to be 2×10−8 cm2/V.
High speed hybrid silicon evanescent Mach-Zehnder modulator and switch (2008)

We demonstrate the first high speed silicon evanescent Mach Zehnder modulator and switch. The modulator utilizes carrier depletion within AlGaInAs quantum wells to obtain V(pi) L of 2 V-mm and clear open eye at 10 Gb/s. The switch exhibits a power penalty of 0.5 dB for all ports at 10 Gb/s modulation.
Immunopathological correlates for accumulation of anaphylactic reactions towards aprotinin within the first 3 months postexposure (2000)

European Society of Anaesthesiologists; 8th Annual Meeting with the Austrian International Congress; Vienna, Austria, 1-4 April 2000
Investigation of the Effect of Position of Straight Sections with Application to the Mark V Spirally Ridged Accelerator (1955)

The purpose of this paper is to estimate the effect of straight sections on σ<sub>r</sub> and σ<sub>z</sub> in a spirally ridged accelerator. For orbits of differing radii, the straight sections occur at different positions relative to the positive and negative gradient regions along the path of the particle. The problem is treated by testing the effect of the straight section position in a magnet obeying a Hill’s equation with the same σ<sub>r</sub> and σ<sub>z</sub> of the spirally ridged accelerator.