gebhart/patrepeval huggingface dataset:
ChemInform Abstract: New Approach to Synthesis of 2‐(5‐Hydroxybenzofuryl‐3)naphthofuran Derivatives. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Detection and identification of a soy protein component that cross-reacts with caseins from cow's milk (2002)

Soy-based formulas are the most employed cow's milk substitutes in the treatment of cow's milk allergy in our country. Since adverse reactions have been reported in allergic patients as a consequence of exposure to soy proteins, we have investigated the possible cross-reactivity between components from soybean and cow's milk. A cow's milk specific polyclonal antiserum and casein specific monoclonal antibodies were used in immunoblotting and competitive ELISA studies to identify a 30-kD component from soybean that cross-reacts with cow's milk caseins. Its IgE binding capacity was tested by EAST, employing sera from cow's milk allergic patients, not previously exposed to soy proteins. The 30 kD protein was isolated and partially sequenced. It is constituted by two polypeptides (A5 and B3) linked by a disulphide bond. The protein's capacity to bind to the different antibodies relies on the B3 poly-peptide. These results indicate that soy-based formula, which contains the A5-B3 glycinin molecule, could be involved in allergic reactions observed in cow's milk allergic patients exposed to soy-containing foods.
Haptic simulation of needle and probe interaction with tissue for prostate brachytherapy training (2011)

This paper presents a haptic simulator for prostate brachytherapy. Both needle insertion and the manipulation of the transrectal ultrasound (TRUS) probe are controlled via haptic devices. These are used to render tissue interaction forces computed using a deformable tissue model based on the finite element method (FEM). Needle flexibility and lateral needle bevel forces are also simulated. The TRUS-tissue simulation allows a trainee to practice the 3D intra-operative placement of the TRUS probe for registration with the pre-operative volume study. The needle-tissue simulation allows a trainee to practice needle insertion and targeting. The TRUS probe and the needle can be maneuvered simultaneously. Approaches to computational acceleration for real-time haptic performance are presented. Trade-offs between accuracy and speed are discussed. A graphics-card implementation of the numerically intensive mesh-adaptation operation is also presented.
Progress in Self‐Healing Fiber‐Reinforced Polymer Composites (2018)

Abstract This paper sets out to review the current state of the art in applying self‐healing/self‐repair to high‐performing advanced fiber‐reinforced polymer composite materials (FRPs). A significant proportion of self‐healing studies have focused so far on developing and assessing healing efficiency of bulk polymer systems, applied to particulate composites or low‐volume fraction fiber‐reinforced materials. Only limited research is undertaken on self‐healing in advanced structural FRP composite materials. This review focuses on what is achieved to date, the ongoing challenges which have arisen in implementing self‐healing into FRPs, how considerations for industrialization and large‐scale manufacture must be considered from the outset, where self‐healing may provide most benefits, and how a functionality like self‐healing can be validated for application in real structures. Systems are compared in terms of process parameters, resulting mechanical properties, methods of healing assessment, as well as values of healing quantification. Guidelines are further given for a concerted effort to drive toward standardization of tests and the use of specific reinforcement architectures in order to allow reliable comparison between the available healing systems in structural composites.
218103 Short-term prediction of pressure fluctuations in a lean premixed gas turbine combustor based on complex network theory (2011)

The radial basis function network based on complex network theory has been applied in this study to predict the time variation in pressure fluctuations generated by combustion instability in a lean premixed gas turbine combustor. The predicted pressure fluctuations for equivalence ratio φ=0.44 partially corresponds to the measured pressure fluctuations. This result indicates that the radial basis function network has potential use for predicting the dynamic behavior of the pressure fluctuations although the time step of the prediction is very small.
Convenient Synthesis and Photophysical Properties of Tetrabenzopentakisdehydro[12]annuleno[12]annulene (2004)

Abstract A convenient synthesis of tetrabenzopentakisdehydro[12]annuleno[12]annulene 2c with substantial solubility was achieved by double cyclization of tetrabromotolan 3 with o-diethynylbenzene 4.
Dielectric And Grating Cerenkov Amplifiers using Pencil and Sheet Electron Beams (1991)

We describe research on low-voltage < 100 kV). moderate power. millimeter-wave Cerenkov amplifiers. Dispersion relations and growth rates have been theoretically studied for sheet beam configurations employing both gratings and dielectric liners. The effects of sidewalls on pencil beam configurations have also been investigated. Cerenkov grating and dielectric liner tapers for input and output coupling are being designed. Plans for an experiment to study basic critical physics issues will be presented. Experimental research topics will include linear and nonlinear gain in rectangular geometry amplifiers using pencil beams, as well as low voltage sheet beam stability and transport with periodic magnetic focusing.
A Re-evaluation of the Photophysical Properties of 1,4-Bis(phenylethynyl)benzene:  A Model for Poly(phenyleneethynylene) (2002)

Photophysical measurements, recorded in aerated cyclohexane at 283 K, indicate that 1,4-bis(phenylethynyl)benzene behaves in a conventional manner, undergoing emission from the lowest vibrational level of the first excited singlet state; there is no evidence for aggregation of this material in cyclohexane solution in the concentration range (1-250) x 10(-6) mol dm(-3). However, in highly viscous, low-temperature glasses, the material does exhibit inhomogeneous fluorescence behavior, and wavelength-dependent excitation and emission spectra, indicative of a slow rate of relaxation of conformers of the excited states compared to the rate of fluorescence.
Construction of a Neisseria gonorrhoeae MS11 derivative deficient in NgoMI restriction and modification (1992)

We have cloned from Neisseria gonorrhoeae MS11 the gene encoding a methylase that modifies the sequence GCCGGC. The corresponding restriction enzyme was also encoded by this clone. Sequence analysis demonstrated that the methylase shares sequence similarities with other cytosine methylases, but the sequence organization of M.NgoMI is different from that seen for other cytosine methylases. A deletion was introduced into the chromosome of N. gonorrhoeae MS11 to produce strain MUG701, a strain that is inactivated in both the methylase and the restriction genes. Although this strain no longer methylated its DNA at the NgoMI recognition sequence, cells were viable and had no other significant phenotypic changes. Transformation data indicated that MS11 does not produce enough restriction activity to block plasmid transformation in the gonococcus, even though restriction activity could be demonstrated in E. coli containing the cloned gene.
Phase II Study of the Anti–Insulin-Like Growth Factor Type 1 Receptor Antibody CP-751,871 in Combination With Paclitaxel and Carboplatin in Previously Untreated, Locally Advanced, or Metastatic Non–Small-Cell Lung Cancer (2009)

These data suggest that PCI(20) is safe and effective in patients with NSCLC.
Enzymatic synthesis of some Wax‐esters (1996)

Abstract The Mucor miehei lipase, immobilized on a macroporous anion‐exchange resin (Lipozyme TM), was used to catalyze esterification and interesterification for the synthesis of wax‐esters. The first series of saturated esters, from 20 to 28 carbon atoms, were obtained with more than 80% yield. These esters are liquid up to 24 carbon atoms. Monounsaturated wax‐esters from 28 to 36 carbon atoms, were synthesized with yields greater than 70%. With few exceptions all these compounds are liquid up to 34 carbon atoms. Attempts of alcoholysis involving the ricinoleyl chain, revealed the remarkable selectivity of Lipozyme. Primary esters were found to be the sole reaction products (yields from 79 to 81,5%). It was possible to prepare diesters from octanediol and suberic acid with good yields (84–92%). Unfortunately yields were moderate in the synthesis of monoesters. 1,2‐alkanediol monolaurates were easily and selectively synthesized, but with a low yield. A fair amount of secondary ester was found besides the expected primary ester. A mechanism involving an equilibrium between both esters via a cyclic intermediate accounted for the acyl migration.
Vieillesse, monde de femmes: un mythe? (1987)

RÉSUMÉ L'auteur s'efforce ici de relativiser la thèse généralement admise dans les milieux gérontologiques et popularisée par l'avocate féministe Louise Dulude dans un article intitulé “Vieillesse, monde de femmes”. Prenant le taux de masculinité âgée comme indicateur, l'article démontre que cette affirmation n'est vraie au Canada que depuis peu et dans les milieux urbains, qu'un pays sur six à travers le monde fait exception à la règle de même que la moitié (9/18) des groupes ethniques de l'Ontario en 1971. Le cas autochtone illustre encore davantage la complexité de la situation. On se rend ainsi compte que la prédominance d'un sexe sur l'autre au troisième âge est conditionnée par une multiplicité de facteurs: biologie, histoire, migrations, ethnicité, milieu (rural-urbain) et occupation.
Engineering applications of relaxation procedures by digital computation (1959)

Abstract A generalized computing method is developed to perform mathematical “relaxation” on a Datatron digital computer. The application of the developed relaxation or iteration procedures results in obtaining numerical solutions to several engineering boundary‐value problems expressed by elliptic differential equations. The developed digital relaxation routine is found to be effective, fast, and practical in solving numerous steady‐state heat and mass transfer problems with arbitrary and quite often complex boundary conditions. While the specific speed and accuracy of the developed digital method is found to depend upon the type of differential equation, the grid size, and computational tolerance requirements, a typical problem indicates that 250 iterations/min. speed and 1% accuracy may be achieved in an average case. The examples presented in this paper are chosen from the more classical heat transfer and temperature and pressure distribution problems in order to indicate some other areas where similar engineering problems can be solved however complex the boundary conditions may be.
<b> <i>Salmonella</i> </b> DNA persistence in natural seawaters using PCR analysis (1997)

The risks of false-positive responses were examined when using the polymerase chain reaction (PCR) method for the detection of Salmonella in the marine environment (water and shellfish). The degradation rates of DNA, both free and from dead Salmonella, were evaluated in natural seawaters maintained at 10 degrees and 20 degrees C, using PCR with Vir and invA primers. The DNA of dead Salmonella was detected up to 55 d in seawater collected in winter and stored at 10 degrees C. But in summer, the persistence was shorter: 10 d or even 2 d for a smaller inoculum (3 x 10(3) Salmonella ml-1). The role of the planktonic organisms present in spring and summer was pinpointed. For free DNA, the persistence times were shorter: from 2 to 4 d at 20 degrees C, and from 3 to 8 d at 10 degrees C showing that the nuclease activity of marine organisms is higher at warm temperatures. These data led us to recommend careful interpretations of direct PCR results, especially during cold periods and for samples collected close to terrestrial discharges of high concentrations of live, dead or lysed Salmonella. PCR is a rapid, specific and sensitive method, but should be applied with care to marine samples, in order to avoid false-positive responses.
Fractionation, Antioxidant Activity, and Cytotoxicity of Cranberry Fruit Extracts (2003)

Cranberries (Vaccinium macrocarpon) are potentially an excellent dietary source of phenolic compounds such as flavonoids, anthocyanins and caffeic acid derivatives which are potent antioxidants. Studies also link a lowered incidence of breast cancer to cranberry juice consumption. In this study, cranberry fruits were fractionated by several methods and tested for radical-scavenging activity in an effort to begin establishing a link between chemical composition and antioxidant activity. The strongest activity was observed in flavonoid-rich extracts. Cytotoxicity assays in several tumor cell lines showed some specificity for HT-29 tumor cells and K562 cells from a methanolic cranberry extract containing several phenolic compounds.
The effect of nitric oxide donors and L-arginine on the gastric electrolyte barrier. (2001)

The potential difference across the stomach wall (PD) is determined by the gastric mucosal barrier. The decrease in the PD evoked by "the barrier breakers", e.g. aspirin, ethanol or bile acids is believed as a sensitive index of the mucosal damage. The effect of glyceryl trinitrate (GTN), isosorbide dinitrate (IDN) and molsidomine (MOL)--all exogenous donors of nitric oxide (NO), as well as L-arginine (L-ARG), which is a substrate for NO-synthase and Nomega-nitro-L-arginine (L-NNA), a non-selective NO synthase inhibitor on the gastric electrolyte barrier were studied against the gastric damage induced by ethanol. All NO donors given intragastrically alone caused only moderate, not significant changes in the PD and failed to affect the mucosal barrier, while L-NNA slightly decreased the PD. The NO donors and L-arginine applied as pretreatment prior to ethanol resulted in diminishing of its damaging action that was similar for all these drugs, while L-NNA intensified both the injury and the drop in the PD values caused by ethanol. In summary, our results showed the protective effect of endogenous nitric oxide from L-ARG and that originating from GTN, MOL and IDN on the gastric electrolyte barrier, supporting involvement of nitric oxide in the mechanism of gastric protection in the stomach.
Monolithic packaging concepts for high isolation in circuits and antennas (1998)

High-frequency planar circuits experience large electromagnetic (EM) coupling in dense circuit environments. As a result, individual components exhibit performance degradation that ultimately limits overall circuit response. This paper addresses crosstalk in planar microstrip lines by evaluating micromachined packages as a means to reduce coupling. Microstrip lines with straight and meandering paths can exhibit crosstalk coupling as high as -20 dB (i.e., when placed in a side-by-side arrangement). From our study, inclusion of a monolithic package reduces this effect by as much as: -30 dB and, consequently, offers the requisite electrical and environmental protection in addition to shielding of individual elements from parasitic radiation. Presented herein is the development of the micromachined package for microstrip geometries. Included in the discussion are crosstalk effects between straight and bending geometries in open and packaged configurations and an evaluation of package noise characteristics. A packaged antenna element is also included as a demonstration of the potential use of micromachined packaging in array applications.
Causes of gas exchange impairment during general anaesthesia. (1988)

This review describes the distribution of ventilation and blood flow in the anaesthetized subject, during spontaneous breathing and after muscle paralysis. Within minutes after induction of anaesthesia, the diaphragm is shifted cranially (supine position), functional residual capacity is reduced and collapse of dependent lung regions can be seen by means of computed tomography. These changes occur whether anaesthesia is intravenous (barbiturate) or inhalational (halothane) and whether ventilation is spontaneous or mechanical. Ventilation is subsequently reduced in dependent lung regions, whereas blood flow is preferentially distributed to the lower lung regions. This causes a ventilation/perfusion mismatch, the hall-mark of which is shunt. Additional factors such as airway closure and release of hypoxic pulmonary vasoconstriction may contribute to the gas exchange disturbance. The major features of the lung function impairment are already present during spontaneous breathing in the anaesthetized subject, and muscle paralysis adds only little to the disturbance.
Development of an optical emission spectroscopy-based method for dynamic compositional analysis of sputter deposited films from multicomponent targets (1995)

A method of calculating as-deposited elemental film composition during the actual deposition process was developed using optical emission spectroscopy of the glow discharge. These results are demonstrated by analyses of a series of thin film Ag1−xSix alloys fabricated using radio frequency sputter deposition with composite Ag+Si sputter targets. Using intensity ratios of the Si (251.6 nm), Ag (328.1 nm), and Ar (419.8 nm) emission lines after equilibration of the substrate temperature, estimates of at. % Si in the films were calculated which agreed well with post-deposition composition measurements of the films by Auger electron spectroscopy.
Toward the structure of the apoE-amyloid beta complex (2015)

info:eu-repo/semantics/nonPublished
Synthesis, biocompatibility and gene encapsulation of poly(2-Ethyl 2-Oxazoline)-dioleoyl phosphatidylethanolamine (PEtOx-DOPE) and post-modifications with peptides and fluorescent dye coumarin (2020)

Liposome surface modifications serve great potential applications of liposomes, for instance, increasing stability, bioactive liposome conjugates, and targeted drug, gene, and image agent delivery. In this study, novel targeted lipopolymers, peptide 18/peptide 563-poly(2-ethyl-2-oxazoline)-dioleoylphosphatidyl-ethanolamine (P18/P563-PEtOx-DOPE), have been demonstrated to be successfully synthesized. The structures of P18/P563-PEtOx-DOPE were confirmed by FT-IR spectroscopy, GPC, and <sup>1</sup>H-NMR. In this strategy, poly(2-ethyl 2-oxazoline)-modified liposomes were firstly constructed with molecular weights of 3,500 and 5,800 Da. Then, we chose PEtOx<sub>5800</sub>-DOPE because it has been obtained better particle size (88.74 ± 0.6816) according to the DLS results. Then, peptides- and dye-PEtOx lipid-based nanovesicle (LN) were prepared by peptide-18, peptide-563, and 7-mercapto-4-methyl coumarin. Genetic material (pDNA) was encapsulated into the liposomes and evaluated the encapsulation of plasmid DNA with migration by using agarose gel electrophoresis. <i>In vitro</i> cytotoxicity experiment results on prostate cancer and breast cancer cell lines, parallelly with the healthy prostate (PNT1A) and breast (MCF10A) epithelial cell lines, cells showed insignificant toxic effects. Thus, we can suggest a novel PEtOx phospholipid thanks to this article and its integration with ligands, which great potential for gene transfer system.
(Invited) ALD of Thin Films for Lithium-Ion Batteries (2011)

Atomic layer deposition (ALD) technique is a thin film deposition method that provides highly conformal films on 3D structured supports, including powder materials. The technique relies on sequential self-limiting gas-to-surface reactions which enable control of thin film depositions even down to the atomic level on complex surface geometries. Even if ALD technique has been used in the semiconductor industry in production scale for several years now, there are rather few reports on ALD of battery materials. However, the recent development in processes for lithium containing films clearly opens up new possibilities. Promising applications of ALD include 3D structured all-solid-state batteries and surface modification of electrode powders. The present paper presents an overview of the present status in application of ALD in the field of lithium ion batteries.
Supracondylar femur fracture above a mature knee fusion treated with a long locked intramedullary rod. (1997)

Fracture around a mature knee fusion has been reported in the orthopedic literature, but little has been written regarding treatment options. Closed long anterograde rodding with interlocking screws offers distinct advantages over other methods of reduction and fixation. The closed nature of the procedure avoids excessive soft-tissue stripping. In comparison with a short unlocked rod or plate, the long locked rod imparts more stability and prevents shortening and rotation. We present a case of a supracondylar femur fracture above a mature knee fusion treated in this manner. The literature on this injury is also reviewed.
Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma (2000)

Because LOH of 12q, 17p, and 18q are significantly associated with a poor prognosis, mutation of the putative tumor suppressor genes on these chromosome arms may play significant roles in the disease progression. Concordant losses of 6q with 17p and of 12q with 18q suggest that protein products of putative tumor suppressor genes on 6q and 12q may function in association with TP53 and SMAD4, respectively.
Spontaneous intracranial hypotension associated with simultaneous rupture of multiple perineural cysts (1999)

Cerebrospinal fluid (CSF) leakage is often considered as a cause of spontaneous intracranial hypotension (SIH) but are not commonly demonstrated radiographically. We report a patient with a 3-week severe postural headache due to SIH whose CT-myelogram showed simultaneous rupture of multiple perineural cysts at different levels of the thoracolumbar spine. Some typical MR pictures of the brain including diffuse meningeal enhancement and descent of the brain were also found. The signs and symptoms and MRI findings of the brain resolved after lumbar epidural blood patching injection.
The metastatic microenvironment: Brain‐residing melanoma metastasis and dormant micrometastasis (2011)

Brain metastasis occurs frequently in melanoma patients with advanced disease whereby the prognosis is dismal. The underlying mechanisms of melanoma brain metastasis development are not well understood. We generated a reproducible melanoma brain metastasis model, consisting of brain-metastasizing variants and local, subdermal variants that originate from the same melanomas thus sharing a common genetic background. The brain-metastasizing variants were obtained by intracardiac inoculation. Brain metastasis variants when inoculated subdermally yielded spontaneous brain dormant micrometastasis. Cultured cells from the spontaneous brain micrometastasis grew very well in vitro and generated subdermal tumors after an orthotopic inoculation. Expression analysis assays indicated that the brain metastasis and micrometastasis cells expressed higher levels of angiopoietin-like 4, prostaglandin-synthesizing enzyme cyclooxygenase-2, matrix metalloproteinase-1 and preferentially expressed antigen in melanoma and lower levels of claudin-1 and cysteine-rich protein 61 than the corresponding cutaneous variants. The reproducible models of human melanoma metastasizing experimentally and spontaneously to the brain will facilitate the identification of novel biomarkers and targets for therapy and contribute to the deciphering of mechanisms underlying melanoma metastasis.