gebhart/patrepeval huggingface dataset:
Continuous lipid treatment of primary human hepatocytes leads to an elevation of oxidative stress (2013)

Non-alcoholic fatty liver disease (NAFLD) is a growing disease in Western societies. It leads to durable morphologic and biochemical changes of liver tissue like inflammatory processes. Thereby a development of steatohepatitis, fibrosis and cirrhosis is possible. These cause decreased liver regeneration as well as less detoxification capacity and may lead to all degree of hepatic failure. Our aim was to establish a long term steatosis model based on primary human hepatocytes (PHH) in order to investigate steatohepatitis related inflammatory processes.
[Doppler echocardiographic study of left ventricular diastolic function in hemodialysis patients]. (2005)

Parameters of diastolic function discriminating value is different from one stage to another. VP characterizes normal pattern, combined indexes restrictive pattern. Vp and isovolumic relaxation time discriminates normal from pseudo-normal pattern.
86.18 Infinitely many primes in arithmetic progressions: the cyclotomic polynomial method (2002)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Gene co-citation networks associated with worker sterility in honey bees (2014)

The networks derived here appear to be variable in gene composition, hub gene identity, and the overall interactions they describe. One interpretation is that workers use different networks to control personal reproduction via ovary activation, perhaps as a function of age or environmental circumstance. Alternatively, the multiple networks inferred here may represent segments of the larger, single network that remains unknown in its entirety. The networks generated here are provisional but do offer a new multi-gene framework for understanding how honey bees regulate personal reproduction within their highly social breeding system.
Sleep apnoea, anxiety, depression and somatoform pain: a community-based high-risk sample (2012)

Community-based studies that measure both psychiatric diagnoses and obstructive sleep apnoea (OSA) are lacking. This study reports current psychiatric disorders in community-dwelling adults at high risk for OSA identified by the Berlin Questionnaire. Furthermore, associations between OSA and current psychiatric disorders, unadjusted and adjusted for putative confounders, are reported. A subsample of the Akershus Sleep Apnoea Project consisting of 290 adults, aged 30-65 yrs, with positive Berlin Questionnaire screening underwent the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, version IV and polysomnography. Auxiliary analyses of depression are provided. The median apnoea/hypopnoea index score in the sample was 7.7 (interquartile range 2.4-22.2). Major depressive disorder, current anxiety and somatoform pain disorder were diagnosed in 12.4%, 14.8% and 19.3% of participants, respectively. At least one psychiatric disorder was diagnosed in 110 participants. The odds ratio of participants with OSA having a psychiatric disorder compared with participants without OSA was 0.54 (95% CI 0.33-0.88). A negative association did not exist among Berlin Questionnaire low-risk participants. In conclusion, more than one-third of participants in a community-based, Berlin Questionnaire high-risk sample were diagnosed with a psychiatric disorder. A negative association between OSA and psychiatric morbidity was found.
Selective Optimization of Side Activities: An Alternative and Promising Strategy for Lead Generation (2016)

The selective optimization of side activities (SOSA) approach uses old drugs for new pharmacological targets. The aim is to screen only a limited number of drug molecules that are structurally and therapeutically diverse and have known safety and bioavailability in humans. The SOSA approach appears to be an efficient strategy for drug discovery, particularly when it is based on the screening of drug molecules thus automatically yielding drug-like hits. By comparing the structures of all drugs, it has been established how many times one marketed drug occurred as a substructure within another marketed drug. This chapter identifies a subset of drugs that can be used in fragment-based drug discovery strategies. The SOSA approach can be compared with other approaches, such as hit or lead generation from known drug metabolites or the design of drug analogs, because it makes use of old drugs to generate new hits or leads.
FAST TEMPLATE MATCHING FOR MEASURING VISIT FREQUENCIES OF DYNAMIC WEB ADVERTISEMENTS (2008)

Abstract: In this paper an on-line method is proposed for statistical evaluation of dynamic web advertisements via measuring their visit frequencies. To minimize the required user-interaction, the eye movements are tracked by a special eye camera, and the hits on advertisements are automatically recognized. The detection step is mapped to a 2D template matching problem, and novel algorithms are developed to significantly decrease the processing time, via excluding quickly most of the false hit-candidates. We show that due to the improvements the method runs in real time in the context of the selected application. The solution has been validated on real test data and quantitave results have been provided to show the gain in recognition rate and processing time versus previous approaches. 1
High-Efficiency Class E/F Lumped and Transmission-Line Power Amplifiers (2011)

The theoretical analysis of a single-ended Class E/F <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</i> mode with explicit derivation of the idealized optimum voltage and current waveforms and load-network parameters with their verification by time- and frequency-domain simulations for a particular case of Class E/F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> mode with a 50% duty cycle are presented. The ideal collector voltage and current waveforms for driving signals with 50% duty cycles demonstrate a possibility of 100% efficiency without overlapping between each other. Two examples of the Class E/F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> GaN HEMT power amplifiers, one with lumped elements at operating frequency of 430 MHz and the other with transmission-line elements at operating frequency of 2.14 GHz, are described and analyzed based on the simulation results. The test board with implemented transmission-line Class E/F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> GaN HEMT power amplifier has been measured and high-performance results with the output power of 40 dBm, drain efficiency of 76%, power-added efficiency of 73.1%, and power gain of 14.3 dB were achieved at operating frequency of 2.14 GHz.
Author interest topic model (2010)

This paper presents a hierarchical topic model that simultaneously captures topics and author's interests. Our proposal, the Author Interest Topic model (AIT), introduces a latent variable with a separate probability distribution over topics into each document. Experiments on a research paper corpus show that the AIT is useful as a generative model.
Achieving laser control of quantum phenomena: balancing computational and experimental capabilities (2004)

An increasing number of experiments have demonstrated that shaped laser pulses can successfully manipulate a broad variety of quantum phenomena. These achievements are drawing on a balance of computational design and high duty cycle closed loop learning control experiments. This paper will consider the special issues involved in best utilizing these capabilities to meet the control objectives. In addition, several topics in the analysis of controlled quantum phenomena will also be considered that draw on these same capabilities.
ChemInform Abstract: Investigation of Bioisosteres of the Growth Hormone Secretagogue L‐692, 429. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nonequilibrium and thermal effects in mode-locked VECSELs (2014)

Ultrafast femtosecond timescale dynamics in Vertical External Cavity Surface Emitting Lasers (VECSELs) have recently been employed to achieve record average power and duration mode-locked pulses by employing different types of saturable absorbers and Kerr Lens elements. Microscopic many-body dynamics are expected to dominate when attempting to push pulse durations below 100 fs. We present a preliminary microscopic simulation of ultrafast mode-locking in order to expose the role of hot carrier distributions in establishing ultrafast mode-locking.
Accurate solution of helical antenna as benchmark for validation of thin-wire modelling (2009)

In this paper, an accurate plate model of helical antenna is developed using WIPL-D Pro, a full wave 3D EM software. Realistic coaxial cable feed below PEC plane is used. All effects resulting from geometry and the principle of work for this type of antenna are fully taken into account, including proximity effect of helical turns and higher order propagation modes at coaxial cable aperture. Thus, all simulation results of this model can be taken as very accurate, since this is confirmed by rigorous convergence tests. By comparing of these results with results of a wire model of helical antenna, limits and applicability of using wire model are precisely determined and explained.
The World Wide Web as an Instructional Tool (1996)

The Internet—and its graphically attractive application, the World Wide Web (WWW)—is potentially a powerful educational tool. Barrie and Presti discuss three ways in which the WWW can be profitably used in education: as a giant encyclopedia, as a virtual classroom, and as a supplement to conventional courses.
The Bipolar Association Case–Control Study (BACCS) and meta‐analysis: No association with the 5,10‐Methylenetetrahydrofolate reductase gene and bipolar disorder (2010)

Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.
Résultats d'une étude multicentrique ouverte du traitement par Thérapie Photodynamique (Photofrin) de 49 malades avec un cholangiocarcinome (2007)

La Thérapie PhotoDynamique (PDT) consiste à exciter par une lumière monochromatique spécifique, dénuée d'effet thermique, un photosensibilisant retenu électivement par les cellules tumorales afin de déclencher une cascade de réactions cytotoxiques. Récemment, plusieurs études prospectives et randomisées, mais monocentriques, ont montré un allongement significatif de la survie des patients avec un cholangiocarcinome traités par PDT et drainage biliaire prothétique versus drainage biliaire seul. Le but de cette étude multicentrique était de recenser, sous l'égide du Club Francophone de Thérapie Photodynamique, de manière prospective depuis septembre 2004, les cas traités par PDT dans notre pays.
Microfabrication of a MEMS piezoresistive flow sensor - materials and processes (2008)

Microelectromechanical systems (MEMS) based artificial sensory hairs for flow sensing have been widely explored, but the processes involved in their fabrication are lithography intensive, making the process quite expensive and cumbersome. Most of these devices are also based on silicon MEMS, which makes the fabrication of out-of plane 3D flow sensors very challenging. This thesis aims to develop new fabrication technologies based on Polymer MEMS, with minimum dependence on lithography for the fabrication of piezoresistive 3D out-of-plane artificial sensory hairs for sensing of air flow. Moreover, the fabrication of a flexible sensor array is proposed and new materials are also explored for the sensing application.\n\nSoft lithography based approaches are first investigated for the fabrication of an all elastomer device that is tested in a bench top wind tunnel. Micromolding technologies allow for the mass fabrication of microstructures using a single, reusable mold master that is fabricated by SU-8 photolithography, reducing the need for repetitive processing. Polydimethylsiloxane (PDMS) is used as the device material and sputter deposited gold is used as both the piezoresistive as well as the electrode material for collection of device response. The fabrication results of PDMS to PDMS metal transfer micromolding (MTM) are shown and the limitations of the process are also discussed. A dissolving mold metal transfer micromolding process is then proposed and developed, which overcomes the limitations of the conventional MTM process pertinent to the present application. Testing results of devices fabricated using the dissolving mold process are discussed with emphasis on the role of micro-cr\n acking as one failure mode in elastomeric devices with thin film metal electrodes.\n\nFinally, a laser microfabrication based approach using thin film Kapton as the device material and an electrically conductive carbon-black elastomer composite as the piezoresistor is proposed and demonstrated. Laminated sheets of thick and thin Kapton form the flexible substrate on which the conductive elastomer piezoresistors are stencil printed. Excimer laser ablation is used to make the micro-stencil as well as to release the Kapton cantilevers. The fluid-structure interaction is improved by the deposition of a thin film of silicon dioxide, which produces a stress-gradient induced curvature, strongly enhancing the device sensitivity. This new approach also enables the fabrication of backside interconnects, thereby addressing the commonly observed problem of flow intrusion while using conventional interconnection technologies like wire-bonding. Devices with varying dimensions of the sensing element are fabricated and the results presented, with smallest devices having a width of 400 microns and a length of 1.5 mm with flow sensitivities as high as 60 Ohms/m/s. Recommendations are also proposed for further optimization of the device.
Automotive Industry Requirements for NEMO Route Optimization (2009)

This document specifies requirements for NEMO Route Optimization
techniques as identified by the automotive industry. Requirements are
gathered from the Car2Car Communication Consortium and ISO Technical
Committee 204 Working Group 16 (CALM).
Reduced Oviposition by Diaprepes abbreviatus (Coleoptera: Curculionidae) and Growth Enhancement of Citrus by Surround Particle Film (2006)

Regularly applied sprays of a particle film, Surround WP, greatly enhanced the growth of citrus trees on a poorly drained Winder soil at Fort Pierce, FL. After 3 yr of applications every 3 or 4 wk, Surround-treated trees had at least 5 times the mass, 6 times the canopy volume, and ≈4 times the cross-sectional area of the tree stems at the graft union compared with untreated trees. The larger Surround-treated trees attracted a higher number of adult weevil Diaprepes abbreviatus (L.) and to a lesser extent citrus root weevil, Pachnaeus litus (Germar), per tree, but there was an equivalent number of egg masses per tree compared with the control trees. The number of egg masses per female weevil oviposited on Surround-treated trees was significantly less than either the control trees or trees treated biannually with an entomopathogenic nematode, BioVector. The number of larvae per tree recovered from the roots of excavated trees was greater from trees treated with Surround once every 3 wk compared with control trees. The data suggest that Surround particle film greatly enhanced the growth of citrus trees grown in a poorly drained soil. The reduction in oviposition by D. abbreviatus was insufficient to significantly reduce the number of root weevil larvae per tree feeding on the roots. However, the more vigorous trees resulting from Surround applications may be more resistant or tolerant to root weevil feeding.
Molecular and functional characterization of the non-isopeptide-selective ETB receptor in endothelial cells. Receptor coupling to nitric oxide synthase. (1994)

Co-transfectQcccQP CHO
Triplet pregnancy in premature ovarian failure after oocyte donation and in vitro fertilization: a case report and review of literature. (1993)

Oocyte donation in premature ovarian failure patients has become an extended indication for In Vitro Fertilization (IVF) procedure. Here the first case report is presented in Taiwan, R.O.C. of a triplet pregnancy in a patient with premature ovarian failure. After an adequate hormonal replacement therapy with oral premarin and intramuscular progesterone for endometrium preparation, the transfer on D15 of four embryos (with donated oocytes and IVF) resulted in implantation of three. Pregnancy support was provided also by oral premarin and intramuscular progesterone until the tenth week of gestational age (GA). The patient received Caesarean section at 35 weeks GA with delivery of three healthy babies weighing 2530 gm, 2420 gm, and 1810 gm respectively on Aug. 17, 1990.
Generalized optimum dynamic bit allocation scheme for source compression (2002)

Dynamic bit allocation directly impacts the overall coding performance in block transform (e.g., DCT, Hadamard, etc.) coding, subband coding, and wavelet coding. In very low bit rate coding (such as the evolving MPEG-4 standard), additional factors impacting the bit allocation process need to be identified and properly exploited to achieve optimal coding performance. In the paper, a generalized optimum dynamic bit allocation algorithm is presented. The algorithm is based on the Shannon rate-distortion bound and a weighted distortion criterion using a Lagrange multiplier optimization technique. The results look promising for applications in real-time multimedia communications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
III-V based THz detectors and plasmon effects (2007)

The THz region is of considerable interest with research on both single element detectors and imagers. Results are reported on heterojunction and homojunction detectors using III-V semiconductor materials. Both Nitride and Antimonide based detectors showed broad response frequencies out to 1 THz. Arsenide based detectors have shown a threshold frequency tailorable in the range of 2.3-20 THz. The mechanisms of operation in these detectors will be discussed, and potential advantages and disadvantages of the materials for various frequency ranges will be considered. Among these are the increased control in tailoring the workfunction in antimonides, and increased THz absorption in the nitrides. The usage of surface plasmon effects in surface structures such as gratings to enhance detector response is also considered. The enhanced frequency for a given grating can be determined from the phase-matching condition. For a grating with 4.5 &mgr;m spacing this leads to increased absorption at 14 &mgr;m. Experimental results on the effects of surface plasmons on absorption and reflection will be presented. Designs for improved THz detectors based on these ideas will also be discussed.
Association of human leukocyte antigen ancestral haplotype 8.1 with adverse outcome of non‐Hodgkin's lymphoma (2007)

Previous reports have implicated the tumor necrosis factor (TNF-308) locus to non-Hodgkin's lymphoma (NHL) outcome. The purpose of the study was to examine other chromosome components of the HLA 8.1 ancestral haplotype (AH) and their relation to the clinical course of NHL. HLA class I, II, TNF-308, and lymphotoxin alpha (LTA+252) alleles were analyzed in 154 newly diagnosed NHL patients. Three locus haplotypes were inferred from the unphased genotypes by a Bayesian implementation of the expectation maximization (EM) algorithm using the PHASE 2.1 program. TNF-308A was the only allele associated with fever, poor performance status, elevated beta2-microglobulin, TNF and its p75 receptor plasma levels. Although TNF-308A was in strong linkage disequilibrium with the remaining alleles of 8.1 AH, only HLA-A*01 and HLA-B*08 showed association with prognostic variables. A part of 8.1 AH (A*01-B*08-TNF-308A) was predictive for shorter freedom from progression and overall survival (RR=2.47, P=0.041; RR=3.15; P=0.0049), an association that was stronger than TNF-308A alone and independent from International Prognostic Index (RR=1.55, P<0.001; RR=2.36; P<0.0001). A*01-B*08-TNF-308A fragment of 8.1 AH remained an independent predictive factor in a multivariate model. We conclude that 8.1 AH is an important contributor to NHL outcome. In contrast to A*01-B*08-TNF(-308A, the remaining alleles (Cw*07, DRB1*03, LTA+252G) associated with the 8.1 AH seem to be its passive components.
Process and Fabrication of Calcium Triphosphate and Hydroxylapatite Microspheres for Clinical Application (2006)

Clinical applications of Calcium phosphate compounds are done in most cases with powders of Calcium-tri-phosphate and/or Hydroxylapatite to enhance the surgery of orthopaedic repair. The application of microspheres of these compounds has big advantages to faster surgery and higher strength of the bone structure. The special processes to produce microspheres of narrow size distribution and high sphericity out Calcium-tri-phosphate and Hydroxylapatite are described. Properties and composition of these microspheres as calcined and as sintered are given.