gebhart/patrepeval huggingface dataset:
Potato tuber necrotic ringspot disease: a genetical approach of the phenomenon and studies about hypersensitive or extreme susceptible behaviour of several cultivars (1992)

*INRA, Station de Pathologie Vegetale, 35650 Le Rheu Diffusion du document : INRA, Station de Pathologie Vegetale, 35650 Le Rheu
ECIR - a Lightweight Approach for Entity-centric Information Retrieval (2010)

This paper describes our system developed for the TREC 2010 Entity track. In particular we study the exploitation of advanced features of different Web search engines to achieve high quality answers for the 'related entity finding'-task. Our system preprocesses a user query using part-of- speech tagging and synonym dictionaries, and generates an enriched keyword query employing advanced features of particular Web search engines. After retrieving a corpus of documents, the system constructs rules to extract candidate entities. Potentially related entities are deduplicated and scored for each document with respect to the distance to the source entity that is defined in the query. Finally, these scores are aggregated across the corpus by incorporating the rank position of a document. For homepage retrieval we further employ advanced features of Web search engines, for instance to retrieve candidate URLs by queries such as 'entity in anchor'. Homepages are ranked by a weighted aggregation of feature vectors. The weight for each individual feature was determined in beforehand using a genetic learning algorithm. We employed a commercial information extraction sys- tem as a basis and implemented our system for three different search engines. We discuss our experiments for the different web search engines and elaborate on the lessons learned.
Surface modes along two parallel circular ferrite rods magnetized longitudinally (1980)

A method is presented for solving the problem of propagation along many parallel ferrite rods magnetized axially. The characteristic determinant is derived from the reciprocity theorem where auxiliary electric and magnetic current sources are suitably selected. Using this method, the dispersion relations and the mode configurations of surface modes along two rods are shown and discussed in detail for both the cases of parallel and antiparallel magnetizations. For each case there generally exists a pair of modes with the same mode number which are backward waves. For the parallel magnetization, the field patterns in the transverse plane are symmetric and antisymmetric, respectively, about the point bisecting the straight-line segment that connects the centers of two rods. For the antiparallel case, the respective modes have the symmetrical and antisymmetrical electric field patterns about the vertical bisector of the same segment; and the results are reversed for the magnetic field patterns. Therefore, the field patterns of the latter first (or second) mode in the half-space exactly coincide with those of the corresponding mode along a single rod over a plane magnetic (or electric) conductor. The latter first mode disappears as the spacing between two rods becomes narrower than a limit. The distributions of the time-averaged power density for all the above modes are found to be symmetric about the above-mentioned vertical bisector. For some modes, there exists a slight local forward power flow in rods, accompanied with a much larger backward flow in the other region. This region with forward flow is found to appear when the strong coupling between two rods occurs. The coupling effects between two rods are more remarkable for the antiparallel case than for the parallel case, and they tend to become weaker for higher modes and for the larger spacing.
Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues threonine351-serine365 of the factor VIII heavy chain. (1988)

We have localized the binding region of a previously described monoclonal anti-factor VIII (FVIII) inhibitory antibody (C5) to amino acid residues Thr351-Ser365 of the thrombin-generated 54-kD fragment of the heavy chain of FVIII. Synthetic FVIII peptides were examined for the ability to competitively inhibit the binding of C5 to FVIII in an ELISA system. The synthetic FVIII peptide Thr351-Ser365 blocked C5 binding to FVIII in a dose-dependent manner in this system. Two other synthetic FVIII peptides, Asn340-Glu354 and Glu342-Asp356, which partially overlapped Thr351-Ser365, also blocked C5 binding to FVIII. Blocking of C5 binding with these peptides, however, required much greater concentrations (greater than 100 times stronger) than that required for Thr351-Ser365. The Thr351-Ser365 peptide also neutralized the FVIII inhibitory activity of C5 in plasma. A human FVIII inhibitor (anti-FVIII heavy chain alloantibody) was also partially neutralized by Thr351-Ser365. Thr351-Ser365 lies between a thrombin cleavage site (Arg372) and an activated protein C cleavage site (Arg336) and may be at or near a region of functional importance in the expression of FVIII procoagulant activity.
Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk (2013)

Mitotic regulator genes have been associated with several cancers, however little is known about their possible association with pancreatic cancer. Smoking and family history are the strongest risk factors for this highly fatal disease. The main purpose of this study was to determine if polymorphisms of mitotic regulator genes are associated with pancreatic cancer and whether they modify the association between cigarette smoking and pancreatic cancer risk. A population-based case-control study was conducted in Ontario with 455 pathology-confirmed pancreatic cancer cases and 893 controls. Cigarette smoking history was collected using questionnaires and DNA obtained from blood samples. Genotypes were determined by mass-spectrometry. Odds ratio estimates were obtained using multivariate logistic regression. Interactions between genetic variant and smoking were assessed using stratified analyses and the likelihood ratio statistic (significance P < 0.05). Variants of MCPH1, FYN, APC, PRKCA, NIN, TopBP1, RIPK1, and SNW1 were not independently associated with pancreatic cancer risk. A significant interaction was observed between pack-years and MCPH1-2550-C > T (P = 0.02). Compared to never smokers, individuals with 10-27 pack-years and MCPH1-2550-CC genotype were at increased risk for pancreatic cancer (MVOR = 2.49, 95% confidence interval [95% CI]: 1.55, 4.00) as were those with >27 pack-years and MCPH1-2550-TC genotype (MVOR = 2.42, 95% CI: 1.45, 4.05). A significant interaction was observed between smoking status and TopBP1-3257-A > G (P = 0.04) using a dominant model. Current smokers with the TopBP1-3257 A allele were at increased risk for pancreatic cancer (MVOR = 2.55, 95% CI: 1.77, 3.67). MCPH1-2550-C > T and TopBP1-3257-A > G modify the association between smoking and pancreatic cancer. These findings provide insights into the potential molecular mechanisms behind smoking-associated pancreatic cancer.
Static and dynamic data modeling for information system design (1982)

This paper illustrates an approach to designing software information systems. We have found this strategy to be sufficiently systematic and practically useful enough to merit exposition for a wider audience. The most novel aspect of our approach is how we analyze the problem in successive steps to produce a logical design. Briefly, the steps are:(1) identify the (classes of) things in the problem's context and the invariant relationships between them.(2) for each (class of) thing that is of central importance to the problem describe the main stages and transitions in the thing's “life” with respect to the problem,(3) synthesize the logical data base structure with attributes determined for all record types using results from the previous two steps.These three steps are the way we model static and dynamic aspects of data as a prerequisite to designing information systems.
Genetic Variations of an Oxidase in Mammals (1967)

Abstract The genetic basis of the variation in activity of the mammalian enzyme which catalyzes the oxidation of N1-methylnicotinamide to N1-methyl-4-pyridone-3-carboxamide has been investigated. The data indicate that in mice the magnitude of the enzyme activity depends on a pair of autosomal alleles, one of which determines a high level, the other a low level, of enzyme activity. Differences in enzyme activity between males and females and the effect of administration of estradiol and of testosterone to intact animals indicate that the level of enzyme activity is subject to hormonal influence as well. Thus, whereas the distinction between classes with low and high enzyme activity is under genetic control, levels of enzyme activity within these classes appear to be regulated by the endocrine system.
Purification of 4,5,6,7-Tetrachlorofluorescein by pH-Zone-Refining Countercurrent Chromatography (1995)

Various factors involved in pH-zone-refining countercurrent chromatography were investigated in the purification of 4,5,6,7-tetrachlorofluorescein, using a two-phase solvent system composed of diethyl ether-acetonitrile-10 mM ammonium acetate (4:1:5). Trifluoroacetic acid (TFA) was added to the sample solution as a retainer acid. The results indicated that 1) increasing the amount of dye improved the yield of pure compounds; 2) increasing the concentration of ammonia in the solvent system increased the concentration of analytes in the mobile phase and shortened the retention time of the major peak; and 3) ammonium acetate in the solvent system could be eliminated and TFA in the sample solution could be replaced by acetic acid without significantly affecting the purification.
Effects of several anthracycline antitumor antibiotics on the transcriptional activity of isolated nucleoli. (1980)

The class II anthracycline antitumor antibiotics musettamycin, rudolfomycin, aclacinomycin and marcellomycin, which were shown in earlier studies to preferentially inhibit the synthesis of nucleolar RNA in intact tumor cells, were studied in an isolated nucleolar transcriptional assay. Their effects were compared with those of the nucleolar non-selective anthracyclines adriamycin, carminomycin and pyrromycin, as well as with the 10-descarbomethoxy-analogs of marcellomycin and rudolfomycin. The isolated nucleolar transcriptional assay was found to have linear activity for 30 minutes at 30 degrees C. At increasing concentrations of alpha-amanatin up to 200 micrograms/ml, the maximum degree of inhibition of transcriptional activity was found to be 6 approximately 7%. The ranking of nucleolar RNA synthesis inhibitory potencies of the class I and II anthracyclines and the 10-descarbomethoxy-analogs obtained previously in intact cells was reproduced in the isolated nucleoli assay system described here. Thus, evidence for the use of this assay as a screen for nucleolar active antitumor agents is presented.
Supporting Increment and Decrement Operations in Balancing Networks. (2000)

Abstract. Counting networks are a class of distributed data structures that support highly concurrent implementations of shared Fetch&amp;Increment counters. Applications of these counters include shared pools and stacks, load balancing, and software barriers [4, 12, 13, 18]. A limitation of counting networks is that the resulting shared counters can be incremented, but not decremented. A recent result by Shavit and Touitou [18] showed that the subclass of tree-shaped counting networks can support, in addition, decrement operations. This paper generalizes their result, showing that any counting network can be extended to support atomic decrements in a simple and natural way. Moreover, it is shown that decrement operations can be supported in networks that provide weaker properties, such as K-smoothing. In general, we identify a broad class of properties, which we call boundedness properties, that are preserved by the introduction of decrements: if a balancing network satisfies a particular boundedness property for
Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (<i>Pueraria lobata</i>) and Danshen (<i>Salvia miltiorrhiza</i>) by high‐performance liquid chromatography (2008)

In order to facilitate the quality control of Traditional Chinese Medicine (TCM) products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza), a new and simple HPLC method for the simultaneous determination of 10 active components in these products has been developed. The chromatographic separation was carried out on a C(18) column eluted with a mobile phase consisting of 0.1% acetic acid in water and 0.1% acetic acid in acetonitrile with gradient elution. The eluent was monitored by a photodiode array UV detector at a wavelength of 250 nm for Gegen components including puerarin, daidzein 8-C-apiosyl-glucoside, daidzin and daidzein, and at 270 nm for Danshen components including danshensu, protocatechuic aldehyde, salvianolic acid B, cryptotanshinone, tanshinone I and tanshinone IIa. Excellent chromatographic separation was achieved for all studied compounds with good linearity (r(2)> 0.999) over the studied concentration ranges. The developed method has been applied to the simultaneous determination of the 10 studied compounds in commercially available products containing both Gegen and Danshen. The TCM product samples were extracted by sonication with a mixture of methanol:water (80:20) containing 0.5% acetic acid. Extraction recoveries for all studied compounds were in the range of 96.01-106.18%. The intra-day and inter-day variations were less than 7.25 and 5.44%, respectively, for all studied compounds. The developed method has not only proved to be effective in the simultaneous determination of the 10 components, but also provides a convenient quality control approach for TCM products containing both Gegen and Danshen.
Assessment of aortic valve area on cardiac computed tomography in symptomatic bicuspid aortic stenosis: Utility and differences from Doppler echocardiography (2022)

GOA<sub>CT</sub> can be used to evaluate the severity of bicuspid AS. The threshold for GOA<sub>CT</sub> for diagnosing severe AS should be higher than that for EOA<sub>Echo</sub>. However, EOA<sub>Echo</sub> is still the method of choice because EOA<sub>Echo</sub> showed better correlations with clinical and functional variables than GOA<sub>CT</sub>.
ChemInform Abstract: N‐Acylimidazolidin‐2‐ones: New Chiral Auxiliaries for Carboxylic Acid Alkylation. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Association between Transillumination Breast Spectroscopy and Quantitative Mammographic Features of the Breast (2008)

Abstract Transillumination breast spectroscopy (TiBS) uses nonionizing optical radiation to gain information about tissue properties directly from the breast. TiBS measurements were obtained from 225 women with normal mammograms. Principal component analysis was used to reduce the spectral data set into four principal components and to generate four TiBS scores (t1-t4) for each woman. These components and scores represent light scattering, water, lipid, and hemoglobin content. Percent density, dense area, and nondense area were measured using Cumulus. The association between TiBS scores and quantitative mammographic features was analyzed using linear regression stratified by menopausal status and adjusted for body mass index. Among premenopausal women, t1 and t3 were significantly associated with percent density (βt1 = −0.14, P = 0.04; βt3 = −2.43, P &lt; 0.0001), whereas t2 and t3 were significantly associated with dense area (βt2 = −1.57, P &lt; 0.0001; βt3 = −2.54, P &lt; 0.0001). Among postmenopausal women, t1, t3, and t4 were significantly associated with percent density (βt1 = −0.30, P &lt; 0.0001; βt3 = −2.51, P &lt; 0.0001; βt4 = 4.75, P &lt; 0.0001) and dense area (βt1 = −0.19, P = 0.004; βt3 = −2.13, P = 0.002; βt4 = 5.02, P &lt; 0.0001). Scores t2 and t4 were also significantly correlated with age among postmenopausal women (rt2 = 0.41 and rt4 = −0.36). Given the association with quantitative mammographic features and tissue changes related to age and menopause, TiBS scores may prove useful as intermediate markers in studies of breast cancer etiology and prevention. (Cancer Epidemiol Biomarkers Prev 2008;17(5):1043–50)
A reverse link outer-loop power control algorithm for cdma2000 1xEV systems (2003)

Reverse link outer-loop power control (ROLPC) algorithms developed for voice systems operate based on a continuous stream of packets (CRC events) to adjust the power control setpoint. Due to burstiness of data traffic a mechanism to distinguish between idle periods and data transmissions is necessary in systems optimized for data communications. In addition, such algorithms are unable to track changes in channel conditions during long idle periods. The proposed algorithm is designed to conservatively adapt to the channel in the absence of packets, with fast convergence at the start of a transmission. A parameterized algorithm is described with analysis and simulation results to justify baseline parameters. The performance of the algorithm for continuous and bursty TCP/IP traffic is presented.
Fast‐Switching Electrochromic Films of Zinc Polyiminofluorene‐Terpyridine Prepared Upon Coordinative Supramolecular Assembly (2008)

Coordinative self-assembly of zinc(II) ions and polytopic polyiminofluorene-tpy ligands is used to prepare electrochromic films with thickness in the nanometer range. The films can be switched between yellow, red, and blue, and exhibit switching times of 500 ms, high contrast, and high stability.
Massively Parallel Processing with Optical Interconnections: What Can Be, Should Be and Must Not Be Done By Optics (1995)

What is wrong about Optical Computing is the implied search for “general purpose computing”. We think that such an attempt has little chance to result in a practical system for, at least, the next ten years. The main reason is the economical justification. What such an “optical computing” system may offer has to be compared with the value of the application and the alternatives (electronics). On the other hand, communication in general is an area where optics has proved to be a real blessing. Long distance communication is most economically done today using optical fibers. We think that another realistic search for good optical applications should now be done for shorter distances. A possible good direction may be the communication needs of Massively Parallel Processing (MPP) systems. In such a system, large number (10’s of thousands) of Processing Elements (PEs) are to be interconnected. A PE can be seen as made of a high-end single chip CPU available today, with memory and communication circuits. We do not view the other possible meaning of MPP, namely processing and interconnections at the single gate or device level, as practical to consider. This paper describes the views of the author from the computer architecture’s standpoint, with the hope to serve as a pointer to the “Optical Computing” community. Although much has been done in the area of optical communication technology for the past 10-20 years, and many optical network experimental systems have been proposed, it seems that optics has not yet found its expected place as the interconnection technology of choice for MPP systems. In this paper we try to suggest some possible reasons preventing the common use of optical interconnections in MPP systems, in a hope to focus attention on what really needs to be done to advance the field. We would suggest focusing on searching for a processing-less solution rather than trying to mimic the existing thinking of electronic networks. We outline several key principles essential to follow to reach realistic and economical solutions of optical interconnections for MPP systems. An example of using such principles for an MPP, free-space network is presented in [1].
Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast (2008)

The data show that a previously underestimated variety of pathways are involved in cadmium and nickel tolerance in eukaryotic cells. As revealed by comparison with five additional metals, there is a good correlation between the chemical properties and the cellular toxicity signatures of various metals. However, many conserved pathways centered on membrane transporters and protein traffic affect cell viability with a surprisingly high degree of metal specificity.
THE RELATIVE AGGRESSIVENESS OF Li, Na, K, Rb, AND Cs BOILING AND CONDENSING IN Nb-1Zr CAPSULES (1965)

Factors influencing replication of serotype 1 Marek's disease vaccines in the lung of chickens within the first 10 days of age (doa) were evaluated. In particular, the effect of vaccine efficacy, age/route of vaccination, and vaccine dose were examined in three experiments. In the first experiment, three vaccine pairs, each pair consisting of a high protective (HP) and a low protective (LP) vaccine (CVI988/BP5 and CVI988-Clone C, 648A80 and 648A100, R2 and R2/23) were used to inoculate chickens subcutaneously (s.c.) with 2000 plaque-forming units (PFU) at hatch. DNA load in the lung was significantly higher in the HP vaccine group than the LP vaccine group at 5 and 10 doa in two of the three vaccine pairs. In the lung, at 5 doa, early MDV gene transcripts (ICP4 and pp38) were detected in most vaccine groups, whereas late MDV gene transcripts (gB and gI) were detected only in the HP vaccine group. In the second experiment, chickens were vaccinated in ovo or s.c. at hatch with 2000 PFU R2, R2/23, or CVI988/BP5. Compared with s.c. vaccination, in ovo vaccination resulted in higher MDV DNA load in the lung at 3 doa, lower or equal MDV DNA load at 5 doa, and lower MDV DNA load at 10 doa. In the third experiment, chickens were vaccinated s.c. at hatch with either 2000 or 10,000 PFU strain R2. There were no statistically significant differences in the load of MDV DNA in the lung after vaccination with R2 between the two doses. Our results showed that HP vaccines tend to replicate better than LP vaccines in the lung; and vaccine replication in the lung within the first 10 days of age was affected by the age/route of inoculation (in ovo versus s.c.) but not by the dose of vaccine administered.
Synthetic Analogues of β-1,2 Oligomannosides Prevent Intestinal Colonization by the Pathogenic Yeast <i>Candida albicans</i> (2002)

The pathogenic yeast Candida albicans displays at its cell surface beta-1,2 oligomannosides (beta-1,2-Mans). In contrast to the ubiquitous alpha-Mans, beta-1,2-Mans bind to galectin-3, a major endogenous lectin expressed on epithelial cells. The specific role of beta-1,2-Mans in colonization of the gut by C. albicans was assessed in a mouse model. A selected virulent strain of C. albicans (expressing more beta-1,2-Man epitopes) induced more intense and sustained colonization than an avirulent strain (expressing less beta-1,2-Man epitopes). Synthetic (Sigma) beta-and alpha-linked tetramannosides with antigenicities that mimicked the antigenicities of C. albicans-derived oligomannosides were then constructed. Oral administration of Sigmabeta-1,2-Man (30 mg/kg of body weight) prior to inoculation with the virulent strain resulted in almost complete eradication of yeasts from stool samples, whereas administration of Sigmaalpha-Man at the same dose did not. As most cases of human systemic candidiasis are endogenous in origin, this first demonstration that a synthetic analogue of a yeast adhesin can prevent yeast colonization in the gut opens the possibility of new prophylactic strategies.