gebhart/patrepeval huggingface dataset:
The Pentameric Nucleoplasmin Fold Is Present in Drosophila FKBP39 and a Large Number of Chromatin-Related Proteins (2015)

Nucleoplasmin is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-terminal tail. The pentameric core domain, a doughnut-like structure with a central pore, is only found in the nucleoplasmin family. Here, we report the first structure of a nucleoplasmin-like domain (NPL) from the unrelated Drosophila protein, FKBP39, and we present evidence that this protein associates with chromatin. Furthermore, we show that two other chromatin proteins, Arabidopsis thaliana histone deacetylase type 2 (HD2) and Saccharomyces cerevisiae Fpr4, share the NPL fold and form pentamers, or a dimer of pentamers in the case of HD2. Thus, we propose a new family of proteins that share the pentameric nucleoplasmin-like NPL domain and are found in protists, fungi, plants and animals.
Fluoride ion-induced skeletal rearrangement (1979)

R. D. Chambers, G. Taylor and R. L. Powell, J. Chem. Soc., Chem. Commun., 1979, 1062 DOI: 10.1039/C39790001062
Evidence for Vesicle Formation during the Synthesis of Catanionic Templated Mesoscopically Ordered Silica as Studied by Cryo-TEM (2002)

The formation of vesicles during the synthesis of mesostructured surfactant-silicate materials has been evidenced for the first time by applying in situ Cryo-TEM. A mixture of anionic and cationic surfactants was used to fine-tune the packing parameter of the supramolecular surfactant assembly. It is shown that the vesicles are formed during the course of the reaction and suggested to be a consequence of silicate condensation reactions. Furthermore, the study confirms earlier suggestions that the silicate-surfactant micelles are capable of solubilizing hydrophobic additives during the early stages of the reaction.
Development of Environmentally Friendly Organometallic Catalysis for Drug Discovery and Its Application to Heterocyclic Chemistry (2007)

Two new catalysts, ruthenium hydride with a nitrogen-containing heterocyclic carbene (A) and an organopalladium catalyst supported on a sulfur-terminated semi-conductor, gallium arsenide (001) (B) were discovered. Both catalysts are environmentally benign, because A can yield indole derivatives with good atom economy, and B can catalyze the Mizoroki-Heck reaction more than 10 times with only trace amounts of leached palladium (ppb level). Substituted 1,2-dihydroquinoline, indole and 3-methylene-2,3-dihydroindole were also prepared selectively from the common starting material, N-allyl-o-vinylaniline, and catalyst by slight modification of the reaction conditions. These procedures address an important issue in diversity-oriented synthesis. These methods utility were demonstrated by application to biologically active natural products synthesis.
Operation of Grid-Connected Cross-Flow Water Turbines in the Stall Region by Direct Power Control (2010)

This paper proposes a new method of controlling cross-flow-water-turbine (CFWT)-based generation systems, having fixed pitch, by power regulation. The method consists of directly controlling the electrical generator power, as imposed by a dispatcher, without employing an inner rotational speed control loop. The proposed control approach represents the base for the operation framework (i.e., output power and rotational speed limitations, start-up, and stopping) for the entire operating range up to the cut-out water flow speed. A permanent-magnet synchronous generator is used in this paper. The system is operated at low rotational speed values, i.e., in the so-called hydrodynamic stall region, where mechanical and hydrodynamic stresses are lower. Given that this region corresponds to an unstable dynamic behavior, the power regulation relies upon an inner loop of rotational-speed stabilization. Consequently, the innermost (electrical machine current) control loop is fed by a reference having two components, namely, the driving and stabilization currents. The embodied control laws and the output power and rotational speed limitation sequences have been experimentally validated on a real-time simulator of CFWT-based generation systems.
Manipulation Of Probiotics Fermentation Of Yogurt By Cinnamon And Licorice: Effects On Yogurt Formation And Inhibition Of Helicobacter Pylori Growth In Vitro (2009)

Probiotic bacteria especially Lactobacillus spp. and Bifidobacterium exert suppressive effect on Helicobacter pylori. Cinnamon and licorice have been traditionally used for the treatment of gastric ulcer. The objectives of this study were to determine the effects of herbs on yogurt fermentation, the level of probiotic bacteria in yogurt during 28 days storage and the effect of herbal yogurt on the growth of H. pylori in vitro. Cinnamon or licorice was mixed with milk and the mixture was fermented with probiotic bacteria to form herbal-yogurt. Changes of pH and total titratable acids were monitored and the viability of probiotic bacteria was evaluated during and after refrigerated storage. The in vitro inhibition of H. pylori growth was determined using agar diffusion and minimum inhibitory concentration (MIC) method. The presence of herbs did not affect the probiotic population during storage. There were no significant differences in pH and TTA between herbal-yogurts and plain-yogurt during fermentation and storage. Water extract of cinnamon-yogurt showed the highest inhibition effect (13.5mm) on H. pylori growth in comparison with licorice-yogurt (11.2mm). The present findings indicate cinnamon and licorice has bioactive components to decrease the growth of H. pylori.
Estimating the in/out function of a surface represented by points (2003)

We present a method to estimate the in/out function of a closed surface represented by an unorganized set of data points. From the in/out function, we compute an approximation of the signed distance function to a surface M whose sampling are given by this set of points. The procedure correctly detects the interior and the exterior of M, even if M is multiply connected. The representation of the signed distance function combines the advantages of two previously known schemes, Implicit Simplicial Models and Adaptively Sampled Distance Fields, incorporating new features deriving from the concept of a Binary Multitriangulation.
HYDROGEN EMBRITTLEMENT OF ZIRCONIUM (1952)

The amount of hydrogen normally present in zirconium and zirconium alloys suffices to reduce their ductility greatly in an impact test at room temperature, after slow cooling from 6OO deg F. Quenching from 6OO deg F or above gives high impact strength, as does removal of hydrogen by hightemperature vacuum aanealing. The evidence on hydrogen embrittlement, the diffusion, solid solubility, and equilbrium pressure of hydrogen in zirconium the microstructure, and the effects of hydrogen and heat treatment on the mechanical properties of zirconium are discussed. (auth)
Reduction of Tire Groove Noise Using Slot Resonators5 (2009)

Abstract Circumferential tire grooves form pipes in the contact patch and generate the nuisance noise, for which the fundamental natural frequency is approximately 1000 Hz for passenger car tires. The frequency coincides with the peak of pass-by noise spectrum. Therefore, controlling the groove resonance is of a main motivation of this paper to reduce environmental noise. If one lateral slot end is terminated in tread rib and if the other end merges to a circumferential groove, it is found that the slot performs as a side-branch or a Helmholtz subresonator to counteract to the pipe resonance. The slot parameters, such as cavity volume and the change in section area, determine the resonant frequency and effectively influence on the acoustic characteristics of whole groove space. Optimal slot geometry is widely investigated by using numerical analysis and validated by experiments. It is shown that the proposed tread design can significantly reduce groove noise without sacrificing other performances.
Line Edge Roughness Comparison Between Wet and Dry Etched Reticles (2002)

We present a comparison of line edge roughness on wet and dry etched reticles manufactured at the same mask shop. These measurements were taken on a Leica LWM250, and compare identical features on both masks. A 30% improvement in line edge quality was seen on the dry etched plates. Data supporting these results is presented.
The Ultraviolet Absorption Spectra of Simple Unsaturated Compounds. I. Mono- and p-Disubstituted Benzene Derivatives (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Ultraviolet Absorption Spectra of Simple Unsaturated Compounds. I. Mono- and p-Disubstituted Benzene DerivativesLeonard Doub and J. M. VandenbeltCite this: J. Am. Chem. Soc. 1947, 69, 11, 2714–2723Publication Date (Print):November 1, 1947Publication History Published online1 May 2002Published inissue 1 November 1947https://pubs.acs.org/doi/10.1021/ja01203a046https://doi.org/10.1021/ja01203a046research-articleACS PublicationsRequest reuse permissionsArticle Views1207Altmetric-Citations298LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Monocytes Downregulates Expression of Adaptive Immune Response Costimulatory Receptors and Proinflammatory Cytokines (2012)

Kaposi's sarcoma-associated herpesvirus (KSHV) infection is associated with the development of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. We report the establishment of a monocytic cell line latently infected with KSHV (KSHV-THP-1). We profiled viral and cytokine gene expression in the KSHV-THP-1 cells compared to that in uninfected THP-1 cells and found that several genes involved in the host immune response were downregulated during latent infection, including genes for CD80, CD86, and the cytokines tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β). Thus, KSHV minimizes its immunological signature by suppressing key immune response factors, enabling persistent infection and evasion from host detection.
Starting mechanisms for high pressure metal halide lamps (2002)

Summary form only given. High pressure metal halide lamps typically have cold fills of a rare gas (usually Ar) of 10 Torr. Starting of the lamp involves applying a high voltage pulse to the electrodes, breaking down the gas, and upon heating produces a thermal arc. Lamps often include auxiliary electrodes to produce preionization, either by electron impact or by photoionization. To investigate these processes, a 2-dimensional lamp model has been developed. The model uses a conformal triangle-based mesh to resolve fine structures. Charged particle transport is based on a drift-diffusion formalism with Sharfetter-Gummel fluxes, solved implicitly coincident with Poisson's equation using a modified Newton's method. Neutral particle transport is separately implicitly solved using the method of successive -over-relaxation. Electron transport coefficients are obtained from either a local-field approximation or by solving the electron energy equation. Plasma properties during startup will be discussed for a selection of electrode geometries, voltage formats and impurity concentrations.
Revisiting the Stokes relations in a time-reversal cavity: Suppression of intraplate echoes induced by a titanium plate (2004)

When focusing through plates or tubes the presence of multiple interfaces induces reflected wavefronts that follow the main wavefront. Adaptive focusing techniques can be used to cancel the echoes. For that purpose, two linear arrays of transducers have been placed on each side of a titanium plate. Three propagation operators have been acquired: transmission from one array to the other, and two reflection operators acquired by each array. In this work, two adaptative focusing methods have been used to cancel the echoes: first, they have been suppressed with a time-reversal mirror, using the two arrays’ cavity surrounding the plate. Second, the echoes have been canceled by using the inverse filter technique, inverting the transmission operator. Thus, the inverse filter achieves echo cancellation by using only the transmitted fields, whereas time reversal also requires the reflected fields. It is shown how transmission and reflection operators are related by the Stokes relations in a matrix formalism. These relations clearly exhibit how the inverse filter takes advantage of the reflections in the medium. An iterative mathematical resolution of these equations yields a new way to invert the transmission operator.
Correlation between oscillations and translational motion of droplets induced by surface acoustic waves: towards low power actuators (2012)

Actuators based on SAW are versatile tools to achieve, atomization, jetting, oscillations, or inner mixing of droplets. Basically, acoustic waves are generated at the surface of a piezoelectric substrate by a transducer consisting of interdigitated fingers. The acoustic energy is then transmitted to the drop whose motion is induced by nonlinear acoustical effects (acoustic streaming, radiation pressure). However, an increase of the temperature occurs inside the drop due to the dissipation of acoustic energy. This could be harmful for the manipulation of biofluids. In this presentation, we will show that the amount of energy required to move or deform droplets can be drastically reduced by exciting them at their eigen frequencies. We will also exhibit and explain the correlation existing between the droplets amplitude of oscillation and their translation speed.
Recurrent diabetic muscle infarction in a female with diabetes secondary to congenital generalised lipodystrophy (2010)

Abstract Congenital generalised Berardinelli‐seip lipodystrophy is a rare, autosomal recessive disorder characterised by selective absence of adipose tissue. Affected individuals are predisposed to severe insulin resistance and its attendant complications, including diabetes mellitus, hypertriglyceridaemia, acute pancreatitis and hepatic steatosis. The management of diabetes in these people can be challenging due to severe insulin resistance. A 25‐year‐old female patient, with diabetes secondary to congenital generalised lipodystrophy, presented to the emergency department with a two‐week history of sudden onset, spontaneous left leg pain associated with swelling over the medial aspect of her left thigh. Her diabetes control prior to presentation was unsatisfactory with HbA 1c >12%, despite receiving maximum doses of metformin, pioglitazone and 200 units of subcutaneous insulin daily. Based on the clinical presentation, background medical history, examination and MRI findings, a diagnosis of diabetic muscle infarction was made. The patient's symptoms resolved over the next four to six weeks with rest and analgesia. Eleven months later, she represented with diabetic muscle infarction affecting her left quadriceps and, after a further 19 months, she had a third admission to hospital with diabetic muscle infarction but this time affecting her right quadriceps. We describe a rare case of recurrent diabetic muscle infarction. This complication has been previously reported in patients with type 1 diabetes of prolonged duration; however, we are not aware of any report of diabetic muscle infarction occurring in patients with diabetes secondary to congenital generalised lipodystrophy. In the current report, we discuss the pathogenesis, clinical course and management of diabetic muscle infarction. Copyright © 2010 John Wiley & Sons.
Sinter-forged YBa sub 2 Cu sub 3 O sub 7-. delta (1987)

High T{sub c} ceramic superconductors, as exemplified by YBa{sub 2}Cu{sub 3}O{sub 7-{delta}}, have recently gained widespread interest in the scientific community. To date, the preparation of this and related materials in powder form has involved, with few exceptions, solid state reaction techniques. The resulting equilibrated powders, which are rather unsinterable, have typically been formed into pellets and fired for subsequent physical measurements. The densities of such pellets are considerably below the theoretical prediction, and the development of more effective sintering processes would clearly be of great importance. In this communication the authors report a technique (sinter-forging) whereby nearly theoretically dense (>95% TD) samples of YBa{sub 2}Cu{sub 3}O{sub 7-{delta}} can be produced. Physical measurements revealed strong texturing and preferred crystallite orientation as well as significant anisotropy in the charge transport.
Automatically Assessing Limb Alignment and Hip Fracture Using 3D Models (2012)

To allow an efficient assessment of lower limb alignment and hip fracture, 3D lower limb bone models are reconstructed from patient-specific computed tomography images. The 3D feature-construction system shown here automatically extracts 3D features (centers, auxiliary points, axes, and planes). No other work exists that automatically marks all the features for the lower extremities.
POKEMON: A non-linear beamforming algorithm for 1-bit massive MIMO (2017)

One-bit quantization at the base-station (BS) of a massive multiple-input multiple-output (MIMO) wireless system enables significant power and cost savings. While the 1-bit uplink (users communicate to BS) has gained significant attention, the downlink (BS transmits to users) is far less studied. In this paper, we propose a novel, computationally-efficient 1-bit beamforming algorithm referred to as POKEMON (short for PrOjected downlinK bEaMfOrmiNg), which-after its convolution with the MIMO channel matrix-minimizes multi-user interference (a.k.a. spatial leakage). Our algorithm builds upon the biconvex relaxation (BCR) framework, which efficiently approximates the optimal 1-bit beamforming problem that is of combinatorial nature. Our simulation results show that POKEMON significantly outperforms linear beamformers followed by 1-bit quantization in terms of error-rate performance and recent non-linear beamformers in terms of complexity.
Cytotoxic activity of<i>Guettarda pohliana</i>Müll. Arg. (Rubiaceae) (2013)

The cytotoxic activity of crude extracts and their fractions from leaves and roots of G. pohliana was assessed against nine human cancer cell lines: melanoma (UACC-62), breast (MCF-7), breast expressing the multidrug resistance phenotype (NCI-ADR), lung (NCI-460), prostate (PCO-3), kidney (786-0), ovarian (OVCAR), colon (HT-29) and leukaemia (K-562). The hexane fraction from leaves (HL) and ethyl acetate (EAR), chloroform (CR) and hydromethanolic (HMR) fractions from roots were the most active fractions against K-562 with GI₅₀ values being lower than 1 μg mL⁻¹. Also, CR and HMR fractions were active against UACC-62 cell line in the same order of magnitude. The phytochemical study of the CR fraction allowed identifying the known iridoids secoxyloganin, sweroside and loganin.
Local Active Suppression by Suppressor Cells in the Decidua: A Review (1984)

The immunological survival of the antigen-bearing mammalian feto-placental unit is determined by the functional properties of the tissues at the feto-maternal interface. Antigen-specific systemic suppressor mechanisms such as suppressor T cells and nonantigen-specific suppressive serum factors appear not to play a major role in protection of the fetus. A novel type of non-MHC specific suppressor cell accumulates locally in the decidua of successfully allopregnant mice. This decidua-associated suppressor is a small lymphocytic cell possessing cytoplasmic granules, lacks T cell markers, and is deficient in number and activity at the implantation sites of viable xenogeneic Mus caroli embryos gestating in the uterus of Mus musculus animals at the time that maternal lymphoid cells begin to infiltrate the xenoembryos. These Mus caroli embryos subsequently resorb. Further experimental studies suggest that the trophoblast cells associated with successful pregnancy recruit bone-marrow derived maternal non-T suppressor cells to the decidua and thus, by an indirect mechanism, may act to protect the fetus from effector cells of the mother's immune system.
New models for backlash and gear play (1997)

Backlash is the most important non-linearity that limits the performance of speed control in industrial drives and is an important impediment to position control as well. A new simple model based on phase plane analysis is derived for an elastic shaft with internal damping connected to a backlash The model is extended to include the case of a so-called flexible coupling, where some of the backlash gap is filled with rubber. Extensive measurements on an industrial drive with a flexible coupling are compared with simulations and fit very well. With internal damping the classical dead-zone model gives an unphysical behaviour of the dynamics. However, the new model converges to the classical dead-zone model when the damping tends to zero. © 1997 by John Wiley & Sons, Ltd.
High -T c edge junctions with Y0.8Pr0.2Ba2Cu2.7Co0.3O7−δ barrier layers near the metal–insulator transition (1997)

We report the use of an epitaxial barrier of Y0.8Pr0.2Ba2Cu2.7Co0.3O7−δ in order to study the effect of Pr in the barrier layer. The bulk behavior of this Pr and Co-doped YBa2Cu3O7−δ (YBCO) material shows it is just on the insulating side of the metal–insulator transition. We present the temperature dependence of the critical current Ic and the resistance Rn for junctions with 150-, 300-, and 450-Å-thick barriers of Y0.8Pr0.2Ba2Cu2.7Co0.3O7−δ. The temperature dependence of the critical currents was analyzed within the framework of the proximity effect of de Gennes. The fittings show that the junctions are in the dirty limit with a diffusion constant of D=2.3 cm2/s and a pair-breaking scattering time of 8.6×10−14 s. The value of the diffusion constant is three times lower than the value we have found in the pure 14% Co-doped YBCO barrier, showing that the Pr doping decreases the mean free path in the junction barrier. The presence of the inelastic pair-breaking process was identified as a key issue in the barrier near the metal–insulator transition.
Limitations of two‐dimensional treatment planning programs (1982)

Some limitations of conventional two-dimensional computer programs used to plan radiation therapy are presented. These include: a lack of involvement in defining the clinical problem; deficiencies in the algorithms for computing dose; failure to compute dose throughout the volume of interest; an inability to handle treatments with noncoplanar beams; failure to provide estimates of error; lack of tools for comparing rival plans; inadequate definition of geometric coverage of anatomic structures by external beams; and failure to provide tools for specifying and verifying the accuracy of treatment delivery. Some suggestions are offered for improvements in some of these areas. In particular, subtraction of dose distributions is proposed as a tool for comparing plans, and displays which exhibit the results of error analyses are presented.