gebhart/patrepeval huggingface dataset:
O-phospho-L-tyrosine protects TP53 wild-type cells against ionizing radiation (2001)

O-phospho-L-tyrosine (P-Tyr) has been reported previously to inhibit growth of several cancer cell lines at mM concentrations. In the present study, we investigated the effect of this compound on tumor cells and normal cells in combination with radiation exposure. It could be demonstrated for the first time that P-Tyr at microM concentrations protects TP53 wild-type cells against ionizing radiation (SF4 minus BBI = 0.28, SF4 plus BBI = 0.45). On the contrary, human transformed or tumor cell lines characterized by mutated or functional inactivated TP53 were not altered or increased in their radiation sensitivity (SF4 minus BBI = 0.32, SF4 plus BBI = 0.22). Treatment of wild-type TP53 cells with P-Tyr induced stabilization of TP53 within 3 and 16 hours and a subsequent increase in CDKN1A expression after treatment. Consequently, a 16-hours pretreatment of cells with P-Tyr led to a significant radioprotective effect. This was not observed in cell lines with mutated TP53, which shows no radioprotection by P-Tyr. Thus, the present data suggest that P-Tyr-mediated radioprotection is dependent on preirradiation stabilization of TP53. The results indicate that P-Tyr is a radioprotective agent that can potentially be very useful and easy to deliver for radiation protection in general and especially in radiation therapy of TP53-mutated tumors.
The Response of Rabbits to Streptococcal Hyperimmunization (1977)

Higher animals possess genetic information that enables them to synthesize a series of antibodies which exhibit sufficient variation in amino acid sequence to include binding sites for a seemingly infinite number of antigens. The genetic basis of this antibody diversity is still very much a mystery whose answer will have far-reaching implications in molecular biology and mammalian genetics. Several theories attempt to explain this diversity, but none has been proved correct. Although many experimental models have provided information concerning immunoglobulin (Ig) genetics, our studies have employed the rabbit because this species has a variety of genetic markers for immunoglobulin molecules and also because antibodies of molecular uniformity can be obtained in large quantities by bacterial hyperimmunization.
Ammonia injection: route to clean stacks. [Efficiency SO/sub 2/ removal from fue gas] (1972)

A patient with Sézary syndrome is presented. By phase contrast and scanning electron microscopy Sézary cells were demonstrated in peripheral blood and in skin tissue. Investigation of atypical mononuclear cells seen in the peripheral blood showed that these cells lack receptors for sheep erythrocytes. C3 and Fcgamma. Similarly, an examination of dermal mononuclear cell infiltrates showed that most of the cells lack receptors for sheep erythrocytes, C3 and Fcgamma.
Chronic rosiglitazone treatment restores AMPKα2 activity in insulin-resistant rat skeletal muscle (2005)

Rosiglitazone (RSG) is an insulin-sensitizing thiazolidinedione (TZD) that exerts peroxisome proliferator-activated receptor-gamma (PPARgamma)-dependent and -independent effects. We tested the hypothesis that part of the insulin-sensitizing effect of RSG is mediated through the action of AMP-activated protein kinase (AMPK). First, we determined the effect of acute (30-60 min) incubation of L6 myotubes with RSG on AMPK regulation and palmitate oxidation. Compared with control (DMSO), 200 microM RSG increased (P < 0.05) AMPKalpha1 activity and phosphorylation of AMPK (Thr172). In addition, acetyl-CoA carboxylase (Ser218) phosphorylation and palmitate oxidation were increased (P < 0.05) in these cells. To investigate the effects of chronic RSG treatment on AMPK regulation in skeletal muscle in vivo, obese Zucker rats were randomly allocated into two experimental groups: control and RSG. Lean Zucker rats were treated with vehicle and acted as a control group for obese Zucker rats. Rats were dosed daily for 6 wk with either vehicle (0.5% carboxymethylcellulose, 100 microl/100 g body mass), or 3 mg/kg RSG. AMPKalpha1 activity was similar in muscle from lean and obese animals and was unaffected by RSG treatment. AMPKalpha2 activity was approximately 25% lower in obese vs. lean animals (P < 0.05) but was normalized to control values after RSG treatment. ACC phosphorylation was decreased with obesity (P < 0.05) but restored to the level of lean controls with RSG treatment. Our data demonstrate that RSG restores AMPK signaling in skeletal muscle of insulin-resistant obese Zucker rats.
Isolation of Highly Proteolytic Mutants from <i>Aspergillus sojae</i> (1969)

Mutational experiments were performed to improve the protease productivity of the mutant strain X-816 previously induced by X-ray irradiation from Asp. sojae K. S. as a high protease producer. The significant correlation was found between the protease production in wheat bran koji and the clear zone around a fungal colony formed on the special medium containing casein. Several mutants of high protease productivity were obtained by the use of the clear zone as a simple criterion for a primary screening test. In this paper, the composition of some other hydrolytic enzymes in wheat bran koji and the genetic stability of these mutants are also discussed.
Assessment of waste tires and plastic on asphalt concrete pavement mixtures (1998)

3rd International Congress on Environmental Geotechnics -- SEP 07-11, 1998 -- LISBON, PORTUGAL
Radially biased diffusion-limited aggregation (1991)

A series of random growth models has been studied in which the growth probability at position r on the surface of the growing cluster is given by P(r)\ensuremath{\simeq}\ensuremath{\mu}(r)${\mathit{l}}^{\mathrm{\ensuremath{\varphi}}}$, where \ensuremath{\mu}(r) is the harmonic measure at r and l is the distance from the seed or origin. The distance l can be either the Pythagorean distance or the minimum path distance measured on the growing cluster. The introduction of this scale-invariant perturbation of the usual diffusion-limited-aggregation (DLA) model (\ensuremath{\varphi}=0) introduces a distance-dependent correlation length, \ensuremath{\xi}=l/\ensuremath{\Vert}\ensuremath{\varphi}\ensuremath{\Vert}, that characterizes a geometrical crossover in the cluster structure. Although the structures generated by these models have an appearance that is quite different from that of DLA clusters (for \ensuremath{\Vert}\ensuremath{\varphi}\ensuremath{\Vert}\ensuremath{\gg}0), the growth of their radii of gyration and the internal density profile \ensuremath{\rho}(r) have simple power-law forms with the same exponents as those associated with DLA. The difference in scaling is manifest in the amplitudes of the power-law forms. These amplitudes exhibit a power-law dependence on the radial bias exponent \ensuremath{\varphi}.For \ensuremath{\varphi}\ensuremath{\gg}1 the clusters become self-affine structures with the same exponents as those associated with DLA on length scales r\ensuremath{\ll}\ensuremath{\xi}. These clusters exhibit a crossover to self-affine wedgelike linearly growing structures at r\ensuremath{\simeq}${\mathit{scrR}}_{\mathit{x}}$\ensuremath{\simeq}\ensuremath{\varphi}. For \ensuremath{\varphi}\ensuremath{\ll}-1 the growth probability is enhanced in the core of the clusters. These clusters exhibit a dense core having radius ${\mathit{scrR}}_{\mathit{x}}$\ensuremath{\sim}\ensuremath{\Vert}\ensuremath{\varphi}\ensuremath{\Vert}. For r\ensuremath{\simeq}${\mathit{scrR}}_{\mathit{x}}$, the structure crosses over to a structure having the same scaling behavior as DLA. For growth from a line in a strip of width L, the density-density correlation function in the lateral direction can be represented by the scaling form ${\mathit{C}}_{\mathit{h}}$(x)\ensuremath{\sim}${\ensuremath{\xi}}^{\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\alpha}}}$g(x/${\ensuremath{\xi}}^{\mathrm{\ensuremath{\alpha}}/\ensuremath{\nu}}$), where h is the distance from the line substrate (height) and exponents \ensuremath{\alpha} and \ensuremath{\nu} have values of about 1/3 and 1/2, respectively. The scaling function g(x) has the form g(x)\ensuremath{\simeq}${\mathit{x}}^{\mathrm{\ensuremath{-}}\ensuremath{\nu}}$ for x\ensuremath{\ll}1 and g(x)\ensuremath{\sim}const for x\ensuremath{\gg}1.
Primary Chemotherapy Followed by a Selective Retro Peritoneal Lymphadenectomy in the Management of Clinical Stage II Testicular Carcinoma: A Preliminary Report (1985)

In 28 patients with primary clinical stage II testicular carcinoma (retroperitoneal mass of less than 10 cm. in diameter) or persistently elevated levels of serum biomarkers after orchiectomy primary chemotherapy was administered followed by selective lymphadenectomy for patients with a persistent retroperitoneal mass. Of the patients 21 were treated with cyclophosphamide, doxorubicin, cisplatin/vinblastine and bleomycin, and 7 who were not candidates for this regimen received less aggressive chemotherapy. All 28 patients were free of disease after a mean followup of 93.6 weeks and a median of 89 weeks (range 28 to 199.5 weeks). No patient who achieved complete remission has had relapse. Of the 28 patients 1 had a seminoma and an elevated alpha-fetoprotein level, 15 had embryonal carcinoma (Dixon-Moore category II) and 12 had teratocarcinomas (Dixon-Moore category IV). Only 1 of the 15 patients with embryonal carcinoma required surgical exploration for a persistent radiographic abnormality, whereas 6 of the 12 patients with Dixon-Moore category IV tumors required surgical exploration (p less than 0.0147). This delayed approach did not increase surgical complications. Our experience with primary chemotherapy followed by selective lymphadenectomy for stage II testicular carcinoma resulted in universal survival. Only 8 of the 28 patients (29 per cent) required lymphadenectomy.
Are G Protein‐Coupled Receptor Heterodimers of Physiological Relevance?—Focus on Melatonin Receptors (2006)

In mammals, the circadian hormone melatonin targets two seven-transmembrane-spanning receptors, MT1 and MT2, of the G protein-coupled receptor (GPCR) super-family. Evidence accumulated over the last 15 yrs convincingly demonstrates that GPCRs, classically considered to function as monomers, are actually organized as homodimers and heterodimerize with other GPCR family members. These dimers are formed early in the biosynthetic pathway and remain stable throughout the entire life cycle. A growing number of observations demonstrate that GPCR oligomerization may occur in native tissues and may have important consequences on receptor function. The formation of MT1 and MT2 homodimers and MT1/MT2 heterodimers has been shown in heterologous expression systems at physiological expression levels. Formation of MT1/MT2 heterodimers remains to be shown in native tissues but is suggested by the documented co-expression of MT1 and MT2 in many melatonin-sensitive tissues, such as the hypothalamic suprachiasmatic nuclei, retina, arteries, and adipose tissue. Considering that multiple GPCRs are expressed simultaneously in most cells, the possible engagement into heterodimeric complexes has to be considered and taken into account for the interpretation of experimental data obtained from native tissues and knockout animals.
Atypical Retinochoroidal Coloboma in Patients With Dysplastic Optic Discs and Transsphenoidal Encephalocele (1995)

In patients with optic disc dysplasias, the finding of this V- or tongue-shaped retinochoroidal pigmentary anomaly should prompt neuroimaging to look for transsphenoidal encephalocele.
Epstein-Barr Virus-Associated Gastric Carcinoma and Atrophic Gastritis (1999)

Although Epstein-Barr virus (EBV) has been reported to be present in some 7% of gastric carcinomas, the nature of the background gastric mucosa of carcinoma has not been elucidated. The authors evaluated the degree of gastritis in the background gastric mucosa of EBV-associated gastric carcinoma. EBV was detected using in situ hybridization for EBV-encoded small ribonucleic acid 1 (EBER-1) in carcinoma cells. The authors compared gastritis in surgically resected stomachs with 8 EBER-1-positive and 16 EBER-1-negative gastric carcinomas of a similar histologic type using histologic variables of the Updated Sydney System. All eight lesions of EBER-1-positive gastric carcinomas had intestinal metaplasia in the background. Mild to moderate glandular atrophy was common in both groups. Many of the tested lesions, 87.5% of EBER-1-positive and 62.5% of EBER-1-negative lesions, were located near the mucosal atrophic border. The background gastric mucosa for EBV-associated gastric carcinomas is rich in atrophic changes. EBV-associated gastric carcinomas are located near the mucosal atrophic border.
Adhesion Molecule Deficiencies Increase<i>Porphyromonas gingivalis</i>-Induced Alveolar Bone Loss in Mice (2000)

ABSTRACT Alveolar bone resorption can be induced in specific-pathogen-free mice by oral infection with Porphyromonas gingivalis (P. J. Baker, R. T. Evans, and D. C. Roopenian, Arch. Oral Biol. 39:1035–1040, 1994). Here we used a mouse strain, C57BL/6J, which is relatively resistant to P. gingivalis -induced bone loss to examine whether partial or complete deletion of various adhesion molecules would increase susceptibility. Complete deletion of P-selectin or nearly complete lack of expression of intercellular adhesion molecule 1 (ICAM-1) led to increased susceptibility to bone resorption after oral infection, while a hypomorphic defect in β 2 -integrins did not. Both the total amount of bone lost and the number of sites at which there was significant loss were increased in mice deficient in either ICAM-1 or P-selectin. Each of the three adhesion molecule deficiencies was sufficient to decrease P. gingivalis -specific serum immunoglobulin G responses, but lower antibody titers did not lead to increased bone loss in partially β 2 -integrin-deficient mice. In conclusion, P-selectin and ICAM-1 deficiencies increase susceptibility to and severity of alveolar bone loss after P. gingivalis infection. This finding underscores the importance of innate immunity in protection against P. gingivalis -induced alveolar bone resorption.
Single-Dose Amoxicillin Therapy for Urinary Tract Infection (1980)

Urine specimens from 134 women with acute, uncomplicated urinary tract infection at three medical centers were examined by the antibody-coated bacteria (ACB) assay. Patients with negative assays (suggesting bladder infection alone) were randomized to receive either a single 3-g oral dose of amoxicillin trihydrate or conventional ten-day courses of sulfa-methoxazole-trimethoprim or oral ampicillin sodium. Comparable results were obtained with the three regimens for ACG-negative infection: 90% eradication of the original organism with single-dose amoxicillin, 100% with sulfamethoxazole-trimethoprim, and 96% with ampicillin. The overall incidence of ACB positivity was 32.1%, ranging from 8% to 63% at the three institutions. This difference seemed to be related to the ease of access to medical care: women with easy access having low rates of ACB positivity and those with poor access having high rates.
Bilateral Bell's palsy at the time of HIV seroconversion (1989)

Premier cas rapporte dans la litterature. Description des signes cliniques et mise en evidence des signes biologiques de seroconversion
Electrochemically Triggered Swinging of a [2]-Catenate (1994)

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTElectrochemically Triggered Swinging of a [2]-CatenateAude Livoreil, Christiane O. Dietrich-Buchecker, and Jean-Pierre SauvageCite this: J. Am. Chem. Soc. 1994, 116, 20, 9399–9400Publication Date (Print):October 1, 1994Publication History Published online1 October 1994Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ja00099a095https://doi.org/10.1021/ja00099a095research-articleACS PublicationsCopyright © 1994 American Chemical Society. This publication is licensed under these Terms of Use. Request reuse permissions This publication is Open Access under the license indicated. Learn MoreArticle Views4238Altmetric-Citations417LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (276 KB) Get e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Activation and Inhibition of Transglutaminase 2 in Mice (2012)

Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and cell signaling activities. It is thought to catalyze sequence-specific deamidation of dietary gluten peptides in the small intestines of celiac disease patients. Because this modification has profound consequences for disease pathogenesis, there is considerable interest in the design of small molecule TG2 inhibitors. Although many classes of TG2 inhibitors have been reported, thus far an animal model for screening them to identify promising celiac drug candidates has remained elusive. Using intraperitoneal administration of the toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly(I∶C)), we induced rapid TG2 activation in the mouse small intestine. Dose dependence was observed in the activation of TG2 as well as the associated villous atrophy, gross clinical response, and rise in serum concentration of the IL-15/IL-15R complex. TG2 activity was most pronounced in the upper small intestine. No evidence of TG2 activation was observed in the lung mucosa, nor were TLR7/8 ligands able to elicit an analogous response. Introduction of ERW1041E, a small molecule TG2 inhibitor, in this mouse model resulted in TG2 inhibition in the small intestine. TG2 inhibition had no effect on villous atrophy, suggesting that activation of this enzyme is a consequence, rather than a cause, of poly(I∶C) induced enteropathy. Consistent with this finding, administration of poly(I∶C) to TG2 knockout mice also induced villous atrophy. Our findings pave the way for pharmacological evaluation of small molecule TG2 inhibitors as drug candidates for celiac disease.
Possible forms of heart-rate variability and their application: use of heart-rate variability in assessment of surgical patients (2002)

A new approach has been proposed for the estimation of variables based on Heart Rate Variability during a surgical operation. The following variables, Heart Rate Variability Index, Normalized Inert Rate Variability Index and Integral Estimation have been introduced and used for the analysis and estimation of surgical procedures in 7 patients. All variables have a clear physical meaning; they are very different at various stages of the operation and facilitate the estimation of the complications of the operation.
Volume MLS Ray Casting (2008)

The method of Moving Least Squares (MLS) is a popular framework for reconstructing continuous functions from scattered data due to its rich mathematical properties and well-understood theoretical foundations. This paper applies MLS to volume rendering, providing a unified mathematical framework for ray casting of scalar data stored over regular as well as irregular grids. We use the MLS reconstruction to render smooth isosurfaces and to compute accurate derivatives for high-quality shading effects. We also present a novel, adaptive preintegration scheme to improve the efficiency of the ray casting algorithm by reducing the overall number of function evaluations, and an efficient implementation of our framework exploiting modern graphics hardware. The resulting system enables high-quality volume integration and shaded isosurface rendering for regular and irregular volume data.
E-conference : An efficient approach for holding a virtual conference (2000)

本書目待補正
Simultaneous material processing by picosecond-pulse bursts and nanosecond pulses arbitrarily generated by a directly modulated laser diode system (2020)

We report a directly modulated laser diode system capable of generating picosecond-pulse bursts and nanosecond pulses simultaneously. A generated pulse shape can be arbitrary controlled with a temporal resolution of 1 ns and wavelength of 1064 nm. A two-stage Nd:YVO 4 amplifier boosts the pulse energy to hundreds of microjoules to process JIS 304 stainless steel. Characterization of processed holes irradiated by different pulse durations and shapes reveals that the ablation efficiencies with the nanosecond pulses are two times higher than those with the picosecond-pulse bursts. A clear hole with a taper angle of 1.5° is realized by the picosecond-pulse bursts with a 10-ns pulse interval. The combination of pulses with large differences in timescales offers an efficient production line with a single laser system.
Control of Multi-Plate Torque Converter Clutch With an Aggressive Schedule in an Automatic Transmission (2007)

In an automatic transmission, torque converter is the main device that transmits torque from the engine to the gear train. An open converter relies on fluid coupling to transmit torque, which causes energy loss and also causes engine to run at a higher speed. A single-plate locking or slipping clutch has been used between the pump and turbine of a torque converter so that the slip across the converter can be reduced to a level that increases the efficiency of the converter. This slip control, called Electronically Controlled Capacity Clutch (ECCC), also provides necessary damping to the driveline to ensure pleasant driveability similar to an open converter. New legislative and environmental pressures on car makers to improve fuel economy have resulted in aggressive use of ECCC in their automobiles. However, the controllability and heat capacity of the single-plate clutch limit the ability to engage the torque converter clutch (TCC) more aggressively (in earlier gears and lower vehicle speeds). At GM, an experimental multi-plate toque converter was designed, fabricated, and implemented in a RWD transmission. It was demonstrated in a 6-speed vehicle that driving pleaseability can be maintained with a more aggressive ECCC strategy. For this purpose, a control algorithm was developed to control the slip speed of the clutch and allow early ECCC starting in second gear. This paper describes in detail hardware implementation of the multi-plate clutch, development and implementation of the aggressive ECCC control strategy, and some vehicle test results.
An empirical Bayes model for gene expression and methylation profiles in antiestrogen resistant breast cancer (2010)

Background
The nuclear transcription factor estrogen receptor alpha (ER-alpha) is the target of several antiestrogen therapeutic agents for breast cancer. However, many ER-alpha positive patients do not respond to these treatments from the beginning, or stop responding after being treated for a period of time. Because of the association of gene transcription alteration and drug resistance and the emerging evidence on the role of DNA methylation on transcription regulation, understanding of these relationships can facilitate development of approaches to re-sensitize breast cancer cells to treatment by restoring DNA methylation patterns.