gebhart/patrepeval huggingface dataset:
DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer (1997)

The product of the dek oncogene is the 43-kDa DEK nuclear protein. DEK was first identified in a fusion with the CAN nucleoporin protein in a specific subtype of acute myelogenous leukemia. DEK has also been shown to be an autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis. Further, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia. However, in spite of these significant disease associations, the function of DEK has remained unclear. The HIV-2 peri-ets (pets) site is a TG-rich element found between the two Elf-1 binding sites in the HIV-2 enhancer. The pets element mediates transcriptional activation whether the enhancer is stimulated by phorbol 12-myristate 13-acetate (PMA) alone, phytohemagluttinin (PHA) alone, PMA plus PHA, soluble antibodies to the T cell receptor, immobilized antibodies to the T cell receptor, or by antigen. Previously, we purified and characterized the pets factor, demonstrating that it is a 43-kDa nuclear protein. We now describe the identification of DEK as this 43-kDa pets factor. Using a modified Southwestern screening procedure, we find that DEK can recognize the pets element. We demonstrate the ability of recombinant DEK to bind specifically to the pets site using the electrophoretic mobility shift assay (EMSA) and DNase I footprinting. "Supershift" EMSA further confirms that DEK is the dominant protein binding to the pets site in T cell extracts. Our findings show that DEK is a site-specific DNA binding protein that is likely involved in transcriptional regulation and signal transduction. This has implications for multiple pathogenic processes, including hematologic malignancies, arthritis, ataxia-telangiectasia, and AIDS caused by HIV-2.
Interleukin-6 and interleukin-11 act synergistically with thrombopoietin and stem cell factor to modulate ex vivo expansion of human CD41+ and CD61+ megakaryocytic cells. (2000)

Our study supports the idea that IL-6 and IL-11 play crucial roles in the proliferation of MK progenitors and the use of SCF, TPO, IL-6 and IL-11 for ex vivo expansion of this cell population.
Persistent parvovirus B19 related anemia of seven years' duration in an HIV-infected patient: Complete remission associated with highly active antiretroviral therapy (1999)

A human immunodeficiency virus (HIV)-infected individual was first diagnosed with red blood cell aplasia due to B19 parvovirus infection in late 1989. Over the subsequent seven-year period, he received a total of 119 units of red blood cells (RBCs) and intravenous immunoglobulin every 2-3 weeks. In 1996 combination antiretroviral treatment with a protease inhibitor was initiated. He received four more units during the following two months and then required no more transfusions for the subsequent 24 months of follow-up. His CD4 count progressively increased and DNA polymerase chain reaction for parvovirus B19 became undetectable. Aggressive antiretroviral treatment may effectively diminish transfusion requirements among HIV-infected individuals with pure RBC aplasia resulting from parvovirus B19 infection.
Selective formation of 2-chloroalkanes from linear alkanes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective formation of 2-chloroalkanes from linear alkanesN. C. Deno, Elizabeth J. Gladfelter, and Douglas G. PohlCite this: J. Org. Chem. 1979, 44, 21, 3728–3729Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://pubs.acs.org/doi/10.1021/jo01335a030https://doi.org/10.1021/jo01335a030research-articleACS PublicationsRequest reuse permissionsArticle Views329Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Coding theory framework for target location in distributed sensor networks (2002)

Distributed, real time sensor networks are essential for effective surveillance in the digitized battlefield and for environmental monitoring. We present the first systematic theory that leads to novel sensor deployment strategies for effective surveillance and target location. We represent the sensor field as a grid (two- or three-dimensional) of points (coordinates), and use the term target at a grid point at any instant in time. We use the framework of unidentified codes to determine sensor placement for unique target location. We provide coding-theoretic-bounds on the number of sensors and present methods for determining their placement in the sensor field. We also show that sensor placement for single targets provides asymptotically complete (unambiguous) location of multiple targets.
Acute hemodynamic and hormonal response to indoramin in congestive heart failure (1984)

Acute hemodynamic and hormonal responses to a single dose of indoramin, an alpha 1-antagonist, were evaluated in 11 subjects with severe chronic congestive heart failure. A hemodynamic effect began within 1 hr of indoramin and persisted during the 6 hr of hemodynamic monitoring. Decreased right and left ventricular filling pressures were associated with increased stroke index and decreased pulmonary and systemic vascular resistances. Heart rate did not increase despite a fall in systemic arterial pressure. Forearm blood flow, forearm venous capacitance, and plasma norepinephrine levels were unchanged, whereas plasma renin activity rose from 12.7 +/- 17.4 to 16.6 +/- 20.4 ng/ml/hr. The only side effect was drowsiness in five of the 11 subjects. Our data demonstrate the acute effectiveness of indoramin in reducing ventricular preload and systemic vascular resistance in heart failure.
Protein Tyrosine Phosphatase Containing SH2 Domains: Characterization, Preferential Expression in Hematopoietic Cells, and Localization to Human Chromosome 12pl2-pl3 (1992)

Protein tyrosine phosphorylation has been implicated in the growth and functional responses of hematopoietic cells. Recently, approaches have been developed to characterize the protein tyrosine phosphatases that may contribute to regulation of protein tyrosine phosphorylation. One novel protein tyrosine phosphatase was expressed predominantly in hematopoietic cells. Hematopoietic cell phosphatase encodes a 68-kDa protein that contains a single phosphatase conserved domain. Unlike other known protein tyrosine phosphatases, hematopoietic cell phosphatase contains two src homology 2 domains. We also cloned the human homolog, which has 95% amino acid sequence identity. Both the murine and human gene products have tyrosine-specific phosphatase activity, and both are expressed predominantly in hematopoietic cells. Importantly, the human gene maps to chromosome 12 region p12-p13. This region is associated with rearrangements in approximately 10% of cases of acute lymphocytic leukemia in children.
Geospatial Data Quality for Analytical Command and Control Applications (2008)

Have you traced a digital representation of a road with so many switchbacks that you questioned the map accuracy? Have you asked an Internet utility to provide a travel route and found the result unintuitive? In each case, flaws in the road network representation may be to blame. Road switchbacks can result from digitization errors such as kinks and kickbacks. Route planning can be defeated by breaks in the network. Much of the digital map data used to represent the physical environment comes from the National Geospatial-Intelligence Agency (NGA). While the NGA has a large holding of internally-produced geospatial data, the agency’s current strategy includes substantial data production under contract and a large cooperative effort with other nations under the Multinational Geospatial Co-production Program (MGCP). The development, codification, and enforcement of detailed quality standards are critical to this acquisition strategy. This paper uses the modeling and simulation application area to exemplify problems that can arise when digital feature data is used for command and control purposes such as automated route planning. This paper describes the type of quality standards that are to be applied in production of geospatial feature data and illustrates a process to transform semantic descriptions into specific guidance suitable for software implementation. The process includes experimentation to determine appropriate reasoning strategies that will permit identification of substandard data while minimizing false positive notifications. The paper describes the impact on simulation entities using the digital data to exemplify a typical problem, details the experiment designed to address the problem, and presents the results of conducting the experiment. The paper concludes with observations on the potential impact of these geospatial data developments on computer applications that use the data in various reasoning domains. 1.
Aiming Accuracy in Ophthalmic Laser Microsurgery (1986)

A number of aiming/focusing systems, oriented toward guiding the treatment beams of photodisruptive, high power Nd:YAG lasers, are analyzed and evaluated. A system, consisting of two frequency modulated, rotating laser beams, which outline the Nd:YAG laser beam shape, is shown to be the optimal solution.
Von Generation zu Generation. Die Bildungsvermittlung im Wandel (2011)

In den Bildungsdiskursen des 21. Jahrhunderts ist die Idee des "lifelong learning" längst zu einem festen Bestandteil geworden. Dabei oszilliert Lebenslanges Lernen zwischen der Chance des andauernden Lernens und der nie endenden persönlichen Entwicklung im Lebenslauf im Sinne der "Potenziale des Alters" (vgl. BMFSFJ 2005; Kocka/Staudinger 2009) auf der einen Seite sowie der Zumutung des unentwegten Lernens und der Anpassung an gewandelte Gegebenheiten des (beruflichen) Lebens auch im fortgeschrittenen Alter auf der anderen Seite (vgl. Autorengruppe Bildungsberichterstattung 2008; BMFSFJ 2005; Gnahs/Kuwan/Seidel 2008; Tippelt u.a. 2009).
Versatile resonance-tracking circuit for acoustic levitation experiments (1978)

Objects can be levitated by radiation pressure forces in an acoustic standing wave. In many circumstances it is important that the standing wave frequency remain locked on an acoustic resonance despite small changes in the resonance frequency. A self-locking oscillator circuit is described which tracks the resonance frequency by sensing the magnitude of the transducer current. The tracking principle could be applied to other resonant systems.
Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy (2005)

Systemic-onset juvenile idiopathic arthritis (SJIA) is a disease of unknown etiology with an unpredictable response to treatment. We examined two groups of patients to determine whether there are serum protein profiles reflective of active disease and predictive of response to therapy. The first group (n = 8) responded to conventional therapy. The second group (n = 15) responded to an experimental antibody to the IL-6 receptor (MRA). Paired sera from each patient were analyzed before and after treatment, using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). Despite the small number of patients, highly significant and consistent differences were observed before and after response to therapy in all patients. Of 282 spectral peaks identified, 23 had mean signal intensities significantly different (P < 0.001) before treatment and after response to treatment. The majority of these differences were observed regardless of whether patients responded to conventional therapy or to MRA. These peaks represent potential biomarkers of active disease. One such peak was identified as serum amyloid A, a known acute-phase reactant in SJIA, validating the SELDI-TOF MS platform as a useful technology in this context. Finally, profiles from serum samples obtained at the time of active disease were compared between the two patient groups. Nine peaks had mean signal intensities significantly different (P < 0.001) between active disease in patients who responded to conventional therapy and in patients who failed to respond, suggesting a possible profile predictive of response. Collectively, these data demonstrate the presence of serum proteomic profiles in SJIA that are reflective of active disease and suggest the feasibility of using the SELDI-TOF MS platform used as a tool for proteomic profiling and discovery of novel biomarkers in autoimmune diseases.
Pathology with clinical correlations of primary central nervous system non-Hodgkin's lymphoma. The massachusetts general hospital experience 1958-1989 (1994)

Primary central nervous system non-Hodgkin's lymphoma has increased in frequency even in nonimunocompromised patient populations. This increase has been accompanied by the disappearance of intermediate grade histologic types, suggesting a fundamental shift in the biology of the neoplasms. The introduction of chemotherapeutic regimens appears to have altered the natural history such that systemic metastases outside the central nervous system no longer occur, and there are now some long term survivors of this formerly uniformly fatal disease.
Capacitance Network Model of the Short Channel Effect for 0.1 µm Fully Depleted SOI MOSFET (1996)

We propose a simple analytical model of the short channel effect in a fully depleted silicon-on-insulator metal-oxide-silicon field effect transistor (SOI-MOSFET). The influence of the two-dimensional effect on the potential distribution, the threshold voltage and the S factor are evaluated based on the spatial distribution of the characteristic capacitances between the SOI body and each electrode (gate, source, drain and substrate). This treatment makes it possible to estimate the two-dimensional effect without solving Poisson's equation which requires a large computation time. This model describes the short channel effect down to the 0.1 µm regime.
Effects of Task Incentive on Cardiovascular Response in Type A and Type B Individuals (1983)

ABSTRACT An experiment was conducted to investigate the interaction of task incentive and the Type A behavior pattern in determining psychomotor performance and psychophysiological responses during a verbal problem solving task. Twenty‐four Type A and 17 Type B subjects as determined by the structured interview were randomly assigned to a Monetary Incentive condition or a Non‐incentive Control condition. Results indicated that the presence or absence of explicit incentives affected task performance for Type As but not for Type Bs. Type As gave more responses more quickly when offered monetary reward. In contrast, the effects of incentive on cardiovascular responses were observed in Type B subjects but not Type As. Type As showed increased systolic blood pressure and heart rate and skeletal muscle vasodilatation in both conditions, while Type Bs showed increased heart rate and systolic blood pressure only when incentives were offered. Type Bs in the Control condition did not change significantly from baseline and actually tended to respond with a deceleration of heart rate and skeletal muscle vasoconstriction. The results are discussed in terms of the need to consider both the interaction of Type A with the nature of the task and the pattern of cardiovascular responses in future studies of psychophysiologic differences between Type A and Type B individuals.
Wireless sensor devices for animal tracking and control (2004)

The paper describes some new wireless sensor hardware developed for pastoral and environmental applications. From our early experiments with Mote hardware, we were inspired to develop our devices with improved radio range, solar power capability, mechanical and electrical robustness, and with unique combinations of sensors. Here we describe the design and evolution of a small family of devices: radio/processor board; a soil moisture sensor interface; a single board multisensor unit for animal tracking experiments.
ChemInform Abstract: NEUE ANALGETIKA UND UMLAGERUNGEN IN DER MORPHIN‐THEBAIN‐GRUPPE 21. MITT. VON 7‐METHYL‐EPI‐NEPENTHON ABGELEITETE ALKOHOLE (1971)

Abstract Aus 7‐Methyl‐epi‐nepenthon (IIa) entstehen bei Reaktion mit Methyl‐MgJ das Carbinol (Ia), bei Reaktion mit Phenyl‐MgBr das (Ia) entsprechende Diphenylcarbinol und bei Reduktion mit Na‐borhydrid in siedendem 2‐Äthoxy‐äthanol der Alkohol (IIIa).
Reexamination of sodium‐liquid ammonia reduction in the peptide chemistry† (1983)

Sodium-liquid ammonia reduction has been used for over 50 years for removal of benzyl-type protecting groups in peptide chemistry. Up until now a definitely blue end-point has generally been accepted for detection of the completion of reaction. Systematic investigation with model compounds has revealed that this is not only unnecessary for the complete removal of the protecting groups but also that the application of sodium in excess results in many undesired transformations which can simply be suppressed or even eliminated by optimizing the sodium consumption. Cleavage of tert.-butyloxycarbonyl group and N-C alpha bond, reduction of carboxamide groups to carbinol derivatives, transpeptidation and formation of a hydantoin derivative have been observed in model experiments by using sodium in excess.
Chemical Medicine: Novel 10‐Substituted Cytisine Derivatives with Increased Selectivity for α4β2 Nicotinic Acetylcholine Receptors (2007)

Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation.
2-Amino-2,3-dihydro-1<i>H</i>-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy (2019)

A series of 2-amino-2,3-dihydro-1<i>H</i>-indene-5-carboxamides were designed and synthesized as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of the representative compounds, <b>7f</b>, bound with DDR1 with a <i>K</i><sub>d</sub> value of 5.9 nM and suppressed the kinase activity with an half-maximal (50%) inhibitory concentration value of 14.9 nM. <b>7f</b> potently inhibited collagen-induced DDR1 signaling and epithelial-mesenchymal transition, dose-dependently suppressed colony formation of pancreatic cancer cells, and exhibited promising in vivo therapeutic efficacy in orthotopic mouse models of pancreatic cancer.
Basic Concept for Granulation (1999)

Field of business in powder handling, it was not directry producted for powders. Because of powder had lots of character, ex. shapes, size distributions and characteristics etc. Therfore, we could not best use of powder's character. Then we granulated for powder and used to object. And it was very easy to handling or next process.In this review, I tried to summarized for fluidized bed granulator.
[Traumatic hyphema]. (1997)

Traumatic hyphema usually occurs in young men at the rate of 17-20/1000,000. Major complications include secondary hemorrhage, glaucoma, corneal staining and disturbances in visual acuity. Final visual acuity is predominantly the outcome of all the ocular injuries occurring during the trauma, mainly to the posterior segment of the eye. We describe all cases of traumatic hyphema treated in our department over a period of 3.5 years. Antifibrinolytic treatment is recommended in the literature in traumatic hyphema to prevent secondary hemorrhage. Our findings differ from those in the literature in that they show a lower prevalence of more severe hemorrhages and of secondary hemorrhage. In light of these differences, and with regard to possible side effects of such treatment, we suggest that antifibrinolytic treatment not be used in our population. We recommend that treatment for traumatic hyphema should include restricted activity, local corti-costeroidal preparations, frequent follow-up visits and vigorous diagnostic work-up in order to find any additional eye damage. We strongly recommend the use of preventive measures (eye-shields) in high risk activities such as sports, house-hold work and military training.
Invited review: A commentary on predictive cheese yield formulas (2010)

Predictive cheese yield formulas have evolved from one based only on casein and fat in 1895. Refinements have included moisture and salt in cheese and whey solids as separate factors, paracasein instead of casein, and exclusion of whey solids from moisture associated with cheese protein. The General, Barbano, and Van Slyke formulas were tested critically using yield and composition of milk, whey, and cheese from 22 vats of Cheddar cheese. The General formula is based on the sum of cheese components: fat, protein, moisture, salt, whey solids free of fat and protein, as well as milk salts associated with paracasein. The testing yielded unexpected revelations. It was startling that the sum of components in cheese was <100%; the mean was 99.51% (N × 6.31). The mean predicted yield was only 99.17% as a percentage of actual yields (PY%AY); PY%AY is a useful term for comparisons of yields among vats. The PY%AY correlated positively with the sum of components (SofC) in cheese. The apparent low estimation of SofC led to the idea of adjusting upwards, for each vat, the 5 measured components in the formula by the observed SofC, as a fraction. The mean of the adjusted predicted yields as percentages of actual yields was 99.99%. The adjusted forms of the General, Barbano, and Van Slyke formulas gave predicted yields equal to the actual yields. It was apparent that unadjusted yield formulas did not accurately predict yield; however, unadjusted PY%AY can be useful as a control tool for analyses of cheese and milk. It was unexpected that total milk protein in the adjusted General formula gave the same predicted yields as casein and paracasein, indicating that casein or paracasein may not always be necessary for successful yield prediction. The use of constants for recovery of fat and protein in the adjusted General formula gave adjusted predicted yields equal to actual yields, indicating that analyses of cheese for protein and fat may not always be necessary for yield prediction. Composition of cheese was estimated using a predictive formula; actual yield was needed for estimation of composition. Adjusted formulas are recommended for estimating target yields and cheese yield efficiency. Constants for solute exclusion, protein-associated milk salts, and whey solids could be used and reduced the complexity of the General formula. Normalization of fat recovery increased variability of predicted yields.