gebhart/patrepeval huggingface dataset:
IMPORTANCE OF LARGE VON WILLEBRAND FACTOR (vWF) MULTIMERS IN vWF INTERACTION WITH PLATELET GLYCOPROTEIN IIb/IIIa (1987)

Recently it has been reported that, in addition to binding to glycoprotein (GP) lb, vWF also interacts with GPIIb/IIIa, although the physiological relevance of this interaction is not completeley clear. In this paper, we have investigated the role of different size of vWF multimers in vWF-mediated platelet aggregation. Different size of vWF multimers were purified from human plasma through Sephacryl S-1000 column according to the method of Fowler et al. Fractions were analysed by SDS-agarose gel electrophoresis by the method of Ruggeri et al. When each fraction was examined for ristocetin cofactor activity (RCo), only larger multimers exhibited significant RCo. The maximum extent of ristocetin-induced platelet agglutination by larger multimers (10 μg/ml) was 80%, while that of intermediate and lower multimers at the same concentration was 20% and 0%, respectively. Each fraction was then added to washed platelet suspensions in the presence of 10 μM ADP and 0.3 mM CaCl2. Only larger multimers induced platelet aggregation, while intermediate and lower multimers failed to induce platelet aggregation. The maximum extent of aggregation in the presence of larger multimers (10 μg/ml) was 70% of that in the presence of fibrinogen instead. Similar experiments were peformed using platelet-rich plasma from a patient with afibrinogenemia in stead of washed normal platelets. ADP caused significant aggregation only when purified vWF larger multimers or fibrinogen was added. This vWF-mediated aggregation was completely inhibited by monoclonal antibody to GPIIb/IIIa (1 μg/ml) and synthetic peptide, Arg-Gly-Asp-Ser, (1 mM). Our results indicate that larger multimers of vWF play major roles in vWF interaction with GPIIb/IIIa.
Personalized recommendation based on the personal innovator degree (2009)

This paper proposes a novel Collaborative Filtering scheme; it focuses on the dynamics and precedence of user preference to recommend items that match the latest preference of the target user. In predicting which items this user will purchase in the near future, the proposed algorithm identifies purchase history logs of users who have similar preferences and a high degree of purchase precedence (i.e., purchasing the same items earlier) relative to the target user. We call this metric the Personal Innovator Degree (PID). Experiments using real online sales data show that the proposed method outperforms existing methods.
Critical Appraisal ofThermo-Mechanical Reliability ofMedium-Power Heterojunction Bipolar Transistors forBaseStation andMilitary Applications Mounted inSOIC-8 Leadframe BasedPlastic Overmold Packages withConductive Silver Epoxy. (2005)

MediumPowerGaInP/GaAs Heterojunction Bipolar Transistors (HBTs) operating upto2.5Watts ofdc dissipation havebeenevaluated vis-a-vis thenno- mechanical reliability whenpackaged intoSOIC-8 leadframe packages withconductive silver-based epoxy. Thenw-mechanical Analyses (TM4)was usedto characterize theglass tansition tempeature (TJ) ofthe molding compound, anddetailed Finite Difference Analysis (FDA) based thermal models weregenerated to characterize thethermal profiles across thepackage. The thermal model results showthat themolding compound layer hasamuchlower temperature distribution than the high device junction temperatures, andalso lower than the measured glass transition temperature, hence minimizing therisk ofdelamination duetothenro-mechanical residual stresses. Thermo-mechanical rg~~~~~~~~~~~~~~~6
Crack‐growth properties of various elastomers with potential application in small joint prostheses (1997)

Silastic small joint spacers for the metacarpo-phalangeal joint fail catastrophically at a reported rate ranging from 2 to 26%. Although the exact cause of this problem is not known, it is speculated that failure is due to the propagation of flaws generated in the material surface. In addition to wear secondary to bony impingement, these flaws can be introduced through manufacturing, surgical handling, and in vivo frictional wear. In an effort to identify an elastomeric material that will function similarly to Silastic as a self-hinging joint spacer but provide an increased functional ife, we have investigated and compared the crack-growth properties of two polyurethanes, ChronoFlex and Medica-flex, and a thermoplastic elastomer, Santoprene, with those of Silastic. The materials were evaluated after sterilization by either ethylene oxide or gamma irradiation in an ASTM standard flexing machine under conditions of high humidity and body temperature both before and after artificially aging. In each case, the materials investigated presented significantly lower crack-growth rates than Silastic (p < 0.001). © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 37, 94–99, 1997.
Diastereoselective Ultrasonically Induced Zinc-copper Conjugate Addition to Chiral α,β-Unsaturated Carbonyl Systems in Aqueous Media (2002)

The diastereoselective ultrasonically induced zinc-copper 1,4-addition of alkyl iodides to chiral α,β-unsaturated systems 1-3 in aqueous media is reported. The reaction of methylenedioxolanone 1 with a variety of alkyl iodides takes place in good yields and with high diastereomeric excess. The 1,4-addition to (Z)- and (E)-γ,δ-dioxolanyl-α,β-unsaturated esters 2 and 3 also proceeds with good yields: the Z-isomer 2 gives good diastereoselectivities while the reactions with the E-isomer 3 are non-stereoselective.
Quasi-optical slot antenna SIS mixers (1992)

A quasi-optical SIS mixer designed for efficient radiation coupling is described. The mixer uses a twin-slot antenna which has the advantages of a good beam pattern and a low impedance. The radiation and impedance characteristics of the antenna were obtained from a moment-matched calculation. Tapered superconducting microstrip transmission lines are used to carry the radiation from the slot antennas to the tunnel junction. The effective impedance seen by the tunnel junction is quite low, about 4 Omega , which allows micron-size junctions to be used at 500 GHz. The mixers have been fabricated using Nb/Al-oxide/Nb tunnel junctions and a receiver noise temperature of 420 K (DSB) was measured at 490 GHz, which is the best yet obtained for a quasi-optical mixer at this frequency. The comparatively large junction area increases the mixer saturation power and allows strong suppression of noise from the Josephson effect by the application of a magnetic field of modest strength.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Structure–Activity Relationship of the Antimicrobial Peptide Gomesin: The Role of Peptide Hydrophobicity in Its Interaction with Model Membranes (2014)

Antimicrobial peptides are part of the innate immune system of animals and plants. Their lytic activity against microorganisms generally depends on their ability to disrupt and permeabilize membranes. Here we study the structure-activity relationship of the antimicrobial peptide gomesin (Gm), from the spider Acanthoscurria gomesiana, with large unilamellar vesicles (LUVs) composed of 3:7 palmitoyloleoyl phosphatidylglycerol: palmitoyloleoyl phosphatidylcholine. Several synthetic analogues of Gm were designed to alter the hydrophobicity/charge of the molecule, whereby selected amino acid residues were replaced by alanine. Isothermal titration calorimetry (ITC) was used to assess the thermodynamic parameters of peptide binding to LUVs and light scattering measurements were made to evaluated peptide-induced vesicle aggregation. The ability of the peptides to permeabilize vesicles was quantified through the leakage of an entrapped fluorescent probe. The activity of peptides could be quantified in terms of the leakage extent induced and their affinity to the membrane, which was largely dictated by the exothermic enthalpy change. The results show that analogues more hydrophobic than Gm display higher activity, whereas peptides more hydrophilic than Gm have their activity almost abolished. Vesicle aggregation, on the other hand, largely increases with peptide charge. We conclude that interaction of Gm with membranes depends on an interplay between surface electrostatic interactions, which drive anchoring to the membrane surface and vesicle aggregation, and insertion of the hydrophobic portion into the membrane core, responsible for causing membrane rupture/permeabilization.
Transition Metal Complexes Containing Functionalized Organoimido and Phosphaneiminato Ligands (2003)

Abstract Two different types of modified imido and phosphaneiminato ligands are investigated, namely chelate ligands and redox‐functionalised ligands. The first examples of di(organoimido)chromium as well as di(phosphaneiminato)titanium and niobium chelates are described. Furthermore, the first complexes containing redox‐functionalised organoimido ligands are presented, together with the first structurally characterised redox‐functionalised phosphaneiminato complex. Compounds of the type [(RN) 2 M(CH 2 Ph) 2 ] (M = Cr, Mo) are used as catalysts for the (co‐)polymerisation of the polar olefins methyl methacrylate, acrylonitrile and vinyl acetate. A range of X‐ray crystal structure determinations provide clear evidence for the quantum‐chemical result that, similar to organoimido complexes, the potential energy well for the angle at the nitrogen atom is very shallow for phosphaneiminato complexes.
Buffer Constrained Proactive Dynamic Voltage Scaling for Video Decoding Systems (2007)

Significant power savings can be achieved on voltage/frequency configurable platforms by dynamically adapting the frequency and voltage according to the workload (complexity). Video decoding is one of the most complex tasks performed on such systems due to its computationally demanding operations like inverse filtering, interpolation, motion compensation and entropy decoding. Dynamically adapting the frequency and voltage for video decoding is attractive due to the time-varying workload and because the utility of decoding a frame is dependent only on decoding the frame before the display deadline. Our contribution in this paper is twofold. First, we adopt a complexity model that explicitly considers the video compression specifics to accurately predict execution times. Second, based on this complexity model, we propose a dynamic voltage scaling algorithm that changes effective deadlines of frame decoding jobs. We pose our problem as a buffer-constrained optimization and show that significant improvements can be achieved over the state-of-the-art dynamic voltage scaling techniques without any performance degradation.
New confidence intervals for the difference between two sensitivities at a fixed level of specificity (2005)

For two continuous-scale diagnostic tests, it is of interest to compare their sensitivities at a predetermined level of specificity. In this paper, we propose three new intervals for the difference between two sensitivities at a fixed level of specificity. These intervals are easy to compute. We also conduct simulation studies to compare the relative performance of the new intervals with the existing normal- approximation-based interval proposed by Wieand et al. Our simulation results show that the newly proposed intervals perform better than the existing normal-approximation-based interval in terms of coverage accuracy and interval length.
A robust front-end algorithm for distributed speech recognition (2001)

This paper presents the robust front-end algorithm that was submitted by Motorola to the ETSI STQ-Aurora DSR working group as a proposal for the Advanced DSR front-end in January 2001. The algorithm consists of a two-stage melwarped Wiener filter, a waveform processor, a channelnormalized mel-frequency cepstral calculation and a subsystem of post-cepstral processing according to the reliability of mel-spectral components, etc. The output of this algorithm, a set of Mel-Frequency Cepstral Coefficients (MFCC), is compressed and encoded based on ETSI ES 201 108 standard; and then it is transmitted at 4800 bps. Compared to ETSI standard MFCC front-end, the proposed algorithm delivers an improvement of 42.64% in performance on the Aurora 2 database, which is required by this Eurospeech Special Event. With a very simple frame deletion algorithm based on a Voice-Onset Detection (VOD), the improvements were significantly boosted to 47.58% on the same database. In this paper we also give further insights about the proposal by providing performances and analyses with the Aurora SpeechDat-Car databases.
Thermodynamic Measurements of Zn–Fe–S–O Equilibria Stable in Air Determined by A Sulfate Concentration Cell At 890–1175k (1986)

Thermodynamic measurements have been made of mixtures of (i) Fe2(SO4)3–Fe2O3, (ii) ZnO·2ZnSO4–ZnSO4, (iii) ZnO·2ZnSO4–ZnO and (iv) ZnFe2O4–ZnO·2ZnSO4–Fe2O3 in air in the temperature range 890–1175 K. Partial pressures of SO3 (g) in equilibrium with the mixtures were measured by means of a concentration cell with a K2SO4 solid electrolyte and a circulating SO3-air reference electrode. Expressions for the standard Gibbs energy were deduced from the results and are generally in good agreement with the recent literature. Data for mixture (iv) are the first thermodynamic measurements for this equilibrium. Résumé On a mesuré les proprietes thermodynamiques des mélanges (i) Fe2 (SO4)3–Fe2O3, (ii) ZnO·2ZnSO4–ZnSO4, (iii) ZnO·2ZnSO4–ZnO et (iv) ZnFe2O4–ZnO·2ZnSO4–Fe2O3 dans l'air, entre 890K et 1175K. Les pressions partielles de SO3 (g) en équilibre avec ces mélanges ont été mesurées it l'aide d'une pile de concentration à électrolyte solide de K2SO4 dont l'électrode de référence est un mélange de SO3-air. Les expressions de l'enthalpie libre de Gibbs déterminées à partir des résultats expérimentaux reproduisent généralement bien les valeurs de la litterature. Les résultats obtenus pour le mélange (iv) représentent les premières mesures de cet équilibre.
Myocardial oxygen consumption and the left ventricular pressure-volume area in normal and hypertrophic canine hearts. (1991)

Basal and nonworking energy demands and working efficiencies of hypertrophic hearts are equivalent to those of normal hearts.
Effects of Surface Modification on Dye-Sensitized Solar Cell Based on an Organic Dye with Naphtho[2,1-b:3,4-b′]dithiophene as the Conjugated Linker (2013)

We have investigated the effects of surface modification on the dye-sensitized solar cell (DSSC) based on a donor-(π-spacer)-acceptor organic dye. A major challenge for donor-(π-spacer)--acceptor molecules as sensitizers in DSSCs is the fast recombination reactions that occur at both the photoanode (e.g., TiO2) surface and the fluorine-doped tin oxide (FTO) electrode, which presents unfavorable effects on the DSSC performance. The two interfaces of TiO2/electrolyte and FTO/electrolyte are passivated selectively in a DSSC using an organic dye with Naphtho[2,1-b:3,4-b']dithiophene as the conjugated linker and the I(-)/I3(-) electrolyte. The current density-voltage characteristics, the dark current analysis, the open circuit voltage-light intensity dependence, and the transient photovoltage/photocurrent results indicate that the recombination processes are affected strongly by surface passivation under variable light intensity. At high light intensity, the recombination reaction at the TiO2 surface is dominant. In this case, silane passivation of the TiO2 surface can suppress recombination significantly, while the c-TiO2 layer makes little contribution to the reduction of the recombination. At low illumination intensity, the recombination at FTO becomes significant, and the recombination can be reduced by applying a c-TiO2 layer.
Consumption of degrees of freedom in adaptive nulling array antennas (1982)

A gradient search technique is used to maximize consumption of the degrees of freedom for N-channel adaptive nulling phased array antennas. The technique is based on a figure of merit which seeks to maximize the sum of the square roots of the interference covariance matrix eigenvalues. Equivalently, the worst case interference source configuration attempts to completely consume N degrees of freedom of the adaptive nulling antenna. Results are given for several basic regularly spaced arrays. The technique can be applied to a phased array with arbitrary array element positions. (Author)
CREEP AND SHRINKAGE IN LIGHTWEIGHT CONCRETE (1959)

DATA ARE GIVEN FOR A LARGE NUMBER OF LABORATORY INVESTIGATIONS THAT HAVE BEEN MADE ON CREEP AND SHRINKAGE IN STRUCTURAL QUALITY LIGHTWEIGHT AGGREGATE CONCRETE. THE AGGREGATES ARE UNCOATED EXPANDED SHALES AND A CLAY PRODUCED IN TEXAS BY THE ROTARY KILN PROCESS. A STUDY IS MADE OF THE EFFECTS OF VARIATIONS IN THE TYPE OF CEMENT AND THE CEMENT CONTENT, THE TYPE OF AGGREGATE AND THE AGGREGATE GRADATION, WATER CONTENT, AIR CONTENT, MIXING TIME, AGE AT TIME OF LOADING, LEVEL OF SUSTAINED COMPRESSIVE STRESS, AND EXPOSURE CONDITIONS. A COMPARISON IS MADE BETWEEN VALUES OBTAINED FROM LABORATORY SPECIMENS AND FROM A FULL-SCALE PRESTRESSED CONCRETE BRIDGE HAVING ONE SPAN OF LIGHTWEIGHT CONCRETE AND ONE SPAN OF SAND-GRAVEL CONCRETE. RECOMMENDATIONS ARE MADE FOR APPLYING LABORATORY DATA TO DESIGN CONDITIONS. /AUTHOR/
[Medication and monitoring in young pediatric patients in NMR (nuclear magnetic resonance) studies]. (1987)

Nuclear magnetic resonance (NMR) is a recently developed, noninvasive technique of increasing importance in pediatric diagnosis. In newborns and very young infants problems may arise with regard to adequate sedation and sufficient patient monitoring during NMR imaging. In 44 of 46 young pediatric patients sedation with oral promazine or rectal diazepam/intravenous ketamine provided good immobilization during NMR scanning. In two patients an additional drug was necessary in order to successfully complete the NMR procedure. Satisfactory monitoring of patients' respiratory motions was obtained by means of a simple optical system. Good cardiovascular monitoring was made possible by lengthening the rubber tubing of a blood pressure cuff. No complications were observed during the NMR-procedures.
Influence of Sintering Modes on Sintering Quality of Mo Products (2007)

In the present paper, the Mo powder produced by JDC was used as the raw material and the influence of sintering modes on sintering quality of mo products was studied by density measurement, microstructure observation and composition analysis. The results show that the bulk average density by electric resistance sintering is higher than that by median frequency sintering. The content of C element under median frequency sintering is higher than that under electric resistance sintering, but it is opposite for 0 element. For median frequency sintering, the quantity of hole at the middle part of the sintered body is obviously more than that of others, but that at the top of the sintered body more for electric resistance sintering, which is accordant with the density measurement. The impurity in the grains is mainly the oxide of molybdenum. The impurities in the grain boundary are composed of both a small quantity of carbon and the complicated metal oxides for median frequency sintering, but both a large number of carbon and a part of metal oxides for electric resistance sintering.
RARE TRISOMY MOSAICISM DIAGNOSED IN AMNIOCYTES, INVOLVING AN AUTOSOME OTHER THAN CHROMOSOMES 13, 18, 20, AND 21: KARYOTYPE/PHENOTYPE CORRELATIONS (1997)

In order to determine the significance of trisomy mosaicism of an autosome other than chromosomes 13, 18, 20, and 21, 151 such cases diagnosed prenatally through amniocentesis were reviewed. These rare trisomy mosaicism cases include 54 from 17 cytogenetic laboratories, 34 from a previous North American mosaicism survey, and 63 from published reports. All were cases of true mosaicism with information available on pregnancy outcome, and with no evidence of biased ascertainment. There were 11 cases of 46/47, +2; 2 of 46/47, +3; 2 of 46/47, +4; 5 of 46/47, +5; 3 of 46/47, +6; 8 of 46/47, +7; 14 of 46/47, +8; 25 of 46/47, +9; 2 of 46/47, +11; 23 of 46/47, +12; 5 of 46/47, +14; 11 of 46/47, +15; 21 of 46/47, +16; 7 of 46/47, +17; 1 of 46/47, +19; and 11 of 46/47, +22. As to the risk of an abnormal outcome, the data showed a very high risk (> 60 per cent) for 46/47, +2, 46/47, +16, and 46/47, +22; a high risk (40-59 per cent) for 46/47, +5, 46/47, +9, 46/47, +14, and 46/47, +15; a moderately high risk (20-39 per cent) for 46/47, +12; a moderate risk (up to 19 per cent) for 46/47, +7 and 46/47, +7 and 46/47, +8; a low risk for 46/47, +17; and an undetermined risk, due to lack of cases, for the remaining autosomal trisomy mosaics. Most cases were evaluated at birth or at termination, so subtle abnormalities may have escaped detection and developmental retardation was not evaluated at all. Comparison of the phenotypes of prenatally diagnosed abnormal cases and postnatally diagnosed cases with the same diagnosis showed considerable concordance. Since the majority of anomalies noted are prenatally detectable with ultrasound, an ultrasound examination should be performed in all prenatally diagnosed cases. In cytogenetic confirmation studies, the data showed much higher confirmation rates in cases with abnormal outcomes than in cases with normal outcomes [81 per cent vs. 55 per cent for fibroblasts (from skin, fetal tissue, and/or cord); 88 per cent vs. 46 per cent for placental cells; 22 per cent vs. 10 per cent for blood cells]. The confirmation rate reached 85 per cent when both fibroblasts and placental tissues were studied in the same case (with trisomic cells found in one or the other, or both). Therefore, one must emphasize that both fibroblasts and placental tissues should be studied. Except for 46/47, +8 and 46/47, +9, PUBS is of limited value for prenatal diagnosis of rate trisomy mosaicism. DNA studies for UPD are suggested for certain chromosomes with established imprinting effects, such as chromosomes 7, 11, 14, and 15, and perhaps for chromosomes 2 and 16, where imprinting effects are likely.
Software bus transceiver (2002)

Frameworks such as "software-buses" enable the integration of different software components into a coherent suite of applications. However, the communication and interoperation between these software components are limited by the boundary of the framework. We describe the software bus transceiver as a translation protocol and supporting architecture to facilitate communication and interoperation of software components from different frameworks. This paper describes the model and the design of the software bus transceiver, the construction of an experimental prototype, and a demonstration scenario that shows how two independent software components can be bridged, using the software bus transceiver, to collaborate on a common task, without any code modification.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>