gebhart/patrepeval huggingface dataset:
Circulating IGF1 and IGF2 and SNP genotypes in men and pregnant and non-pregnant women (2014)

Circulating IGFs are important regulators of prenatal and postnatal growth, and of metabolism and pregnancy, and change with sex, age and pregnancy. Single-nucleotide polymorphisms (SNPs) in genes coding for these hormones associate with circulating abundance of IGF1 and IGF2 in non-pregnant adults and children, but whether this occurs in pregnancy is unknown. We therefore investigated associations of plasma IGF1 and IGF2 with age and genotype at candidate SNPs previously associated with circulating IGF1, IGF2 or methylation of the INS – IGF2 – H19 locus in men ( n =134), non-pregnant women ( n =74) and women at 15 weeks of gestation ( n =98). Plasma IGF1 concentrations decreased with age ( P <0.001) and plasma IGF1 and IGF2 concentrations were lower in pregnant women than in non-pregnant women or men (each P <0.001). SNP genotypes in the INS – IGF2 – H19 locus were associated with plasma IGF1 ( IGF2 rs680, IGF2 rs1004446 and IGF2 rs3741204) and IGF2 ( IGF2 rs1004446, IGF2 rs3741204 and H19 rs217727). In single SNP models, effects of IGF2 rs680 were similar between groups, with higher plasma IGF1 concentrations in individuals with the GG genotype when compared with GA ( P =0.016), or combined GA and AA genotypes ( P =0.003). SNPs in the IGF2 gene associated with IGF1 or IGF2 were in linkage disequilibrium, hence these associations could reflect other genotype variations within this region or be due to changes in INS – IGF2 – H19 methylation previously associated with some of these variants. As IGF1 in early pregnancy promotes placental differentiation and function, lower IGF1 concentrations in pregnant women carrying IGF2 rs680 A alleles may affect placental development and/or risk of pregnancy complications.
Head Kidney-Derived Macrophages of Common Carp ( <i>Cyprinus carpio</i> L.) Show Plasticity and Functional Polarization upon Differential Stimulation (2006)

Cells from the myeloid lineage are pluripotent. To investigate the potential of myeloid cell polarization in a primitive vertebrate species, we phenotypically and functionally characterized myeloid cells of common carp (Cyprinus carpio L.) during culture. Flow cytometric analysis, Ab labeling of cell surface markers, and light microscopy showed the presence of a major population of heterogeneous macrophages after culture. These head kidney-derived macrophages can be considered the fish equivalent of bone marrow-derived macrophages and show the ability to phagocytose, produce radicals, and polarize into innate activated or alternatively activated macrophages. Macrophage polarization was based on differential activity of inducible NO synthase and arginase for innate and alternative activation, respectively. Correspondingly, gene expression profiling after stimulation with LPS or cAMP showed differential expression for most of the immune genes presently described for carp. The recently described novel Ig-like transcript 1 (NILT1) and the CXCR1 and CXCR2 chemokine receptors were up-regulated after stimulation with cAMP, an inducer of alternative activation in carp macrophages. Up-regulation of NILT1 was also seen during the later phase of a Trypanosoma carassii infection, where macrophages are primarily alternatively activated. However, NILT1 could not be up-regulated during a Trypanoplasma borreli infection, a model for innate activation. Our data suggest that NILT1, CXCR1, and CXCR2 could be considered markers for alternatively activated macrophages in fish.
1550 nm eye-safe wavelength watt-level laser transmitter for space communication and lidar (Conference Presentation) (2017)

A master-oscillator power amplifier (MOPA) based 1550 nm wavelength fiber laser transmitter has been developed for Space-to-Earth communication application, utilizing Telcordia rated 1550 nm seed laser, pump lasers, and fiber optics. With adequate pre-screening of electrical components, the fiber laser transmitter has been in operation since its original launch in April 2014, for 30 months. This presents as a relatively cost-effective route for low-earth-orbit optical communication as well as LIDAR applications.
Structure and Activity of <i>Aspergillus nidulans</i> Copper Amine Oxidase (2011)

Aspergillus nidulans amine oxidase (ANAO) has the unusual ability among the family of copper and trihydroxyphenylalanine quinone-containing amine oxidases of being able to oxidize the amine side chains of lysine residues in large peptides and proteins. We show here that in common with the related enzyme from the yeast Pichia pastoris, ANAO can promote the cross-linking of tropoelastin and oxidize the lysine residues in α-casein proteins and tropoelastin. The crystal structure of ANAO, the first for a fungal enzyme in this family, has been determined to a resolution of 2.4 Å. The enzyme is a dimer with the archetypal fold of a copper-containing amine oxidase. The active site is the most open of any of those of the structurally characterized enzymes in the family and provides a ready explanation for its lysine oxidase-like activity.
ChemInform Abstract: Asymmetric Reaction Catalyzed by Chiral Metal Complexes. Part 71. Asymmetric Cyclization of 3,4‐Dihydro‐2‐vinyl‐2H‐1,4‐benzoxazine Catalyzed by Palladium‐BHMP Catalyst. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An athermal deformation model of the yield stress anomaly in Ni3Al (2007)

Abstract An athermal deformation model was proposed for the yield stress anomaly in Ni3Al based on the concept that dislocation multiplication versus the immobilization by the Kear–Wilsdorf (KW) locking controls the plastic deformation. In the model dislocations, superkinks lying between two KW locks multiply through expansion in an athermal manner. Regarding the KW locking, the entire screw segment cross-slips onto (010) to form long KW locks in one thermal activation event. The model can explain the macroscopic characteristics of the deformation, the strain-rate independent of the yield stress and the compliance with Schmid's law, which were recently revealed in binary, stoichiometric Ni3Al single crystals. Quantitative assessment proved that the model reproduces the temperature dependence of the yield stress with reasonable fitting parameters. The driving force for the KW locking, one of the most important parameters for the yield stress anomaly, was evaluated at 127 mJ m−2. This value is in good agreement with those calculated from the anti-phase boundary energies on {111} and {100} reported in the literature.
Surgical Management of Perilymph Fistulas: A New Technique (1991)

A wide range of recurrence rates (21% to 47%) for perilymph fistula repairs have been reported in the otology literature. An improved surgical technique developed at the Portland (Ore) Good Samaritan Hospital and Medical Center Neurotology Department was used to repair perilymph fistulas in 58 patients from October 1986 to October 1988. Our recurrence rate was reduced from 27% in a 1982-1985 study to 8% in our study. At 1 year postoperatively, improvements in disequillibrium, dizziness, and vertigo were comparable with results of older surgical techniques. Functional outcomes were also good: 83% of patients returned to normal activities of daily living, and 71% also returned to school or resumed gainful employment outside the home.
Transparent Polyelectrolyte Complex Thin Films with Ultralow Oxygen Transmission Rate (2018)

Limiting oxygen permeation through plastic films is important for extending the shelf life of food and flexible electronic devices. Polyelectrolyte complex (PEC) thin films can be used to reduce small molecule diffusion through commodity plastic films. PEC thin films are frequently applied using layer-by-layer assembly, which often requires many processing cycles to deposit a film with desired thickness. An aqueous solution of poly(diallydimethylammonium chloride) and poly(acrylic acid) can be deposited in a single-step to quickly fabricate a high-oxygen barrier thin film. These films have an ionically bonded network that forms after polyelectrolyte deposition and exposure to buffer. Increasing buffer concentration and adding salt increases film cohesion and improves transparency by reducing surface roughness. When deposited onto a 178 μm poly(ethylene terephthalate) film, a ∼1.9 μm thick PEC coating imparts a 2 orders of magnitude reduction in oxygen transmission rate. Achieving this level of gas barrier with a single thin coating layer creates numerous opportunities for the protection of sensitive food, pharmaceuticals, and electronics.
Salicylic Acid Conjugated Dendrimers Are a Tunable, High Performance CEST MRI NanoPlatform (2016)

Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is well suited for imaging, however, existing small molecule CEST agents suffer from low sensitivity. We have developed salicylic acid conjugated dendrimers as a versatile, high performance nanoplatform. In particular, we have prepared nanocarriers based on generation 5-poly(amidoamine) (PAMAM) dendrimers with salicylic acid covalently attached to their surface. The resulting conjugates produce strong CEST contrast 9.4 ppm from water with the proton exchange tunable from ∼1000 s(-1) to ∼4500 s(-1) making these dendrimers well suited for sensitive detection. Furthermore, we demonstrate that these conjugates can be used for monitoring convection enhanced delivery into U87 glioblastoma bearing mice, with the contrast produced by these nanoparticles persisting for over 1.5 h and distributed over ∼50% of the tumors. Our results demonstrate that SA modified dendrimers present a promising new nanoplatform for medical applications.
IR and EPR study of ammonia adsorption effect on silicon nanocrystals (2009)

Abstract IR and EPR spectroscopy is used to investigate the effect of adsorption of dry and wet ammonia on the concentration of equilibrium charge carriers in porous silicon layers with various initial types of dopants. It is found by means of IR spectroscopy that only in the presence of water molecules the ammonia adsorption results in an increase in the concentration of free charge carriers in n‐type samples up to a level exceeding 10 18 cm –3 . In p‐type samples, a nonmonotonic dependence of the charge‐carrier concentration on ammonia pressure is observed. By means of EPR spectroscopy in the atmosphere of wet ammonia the generation of conduction‐band electrons in p‐type silicon nanocrystals and the increase in the electron concentration in n‐type silicon nanocrystals in comparison with the initial level are observed. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Wideband Microwave Power Sensor Based on MEMS Technology (2004)

An optimized transmission-type MEMS RF power sensor is presented. The design is based on microwave filter theory. It is shown that the thermal resolution of the sensor can be reduced below -50 dBm for RF bandwidths up to les 40 GHz
Operation of transition-edge sensors with excess thermal noise (2006)

The superconducting transition-edge sensor (TES) is currently one of the most attractive choices for ultra-high resolution calorimetry in the keV x-ray band, and is being considered for future ESA and NASA missions. We have performed a study on the noise characteristics of Au/Ti bilayer TESs, at operating temperatures around ~100 mK, with the SQUID readout at 1.5 K. Experimental results indicate that without modifications the back-action noise from the SQUID chip degrades the noise characteristics significantly. We present a simple and effective solution to the problem: by installing an extra shunt resistor which absorbs the excess radiation from the SQUID input, we have reduced the excess thermal (photon) noise power down by approximately a factor of five, allowing high resolution operation of the sensors.
Current Trends in the Use of Allograft Skin for Patients With Burns and Reflections on the Future of Skin Banking in the United States (1994)

Cadaveric allograft skin can play a critical role in the care of patients with massive burns. It is difficult, however, to estimate current use and levels of enthusiasm for allograft skin in the United States. We report on a survey of 40 skin banks and 140 United States burn center medical directors as listed in the American Burn Association's Directory of Burn Care Resources for North America 1991-1992. Response rate was 45% for skin banks and 38% for burn directors. Overall, 12% of admitted patients were treated with allograft skin at the responding burn centers. Sixty-nine percent of burn center directors preferred to use fresh skin, although only 47% of skin banks were able to supply fresh cadaver skin. Tabulated survey results and a review and discussion of future directions in skin banking and replacement research are discussed in this paper and were presented to the Tissue Bank Special Interest group at the 1993 American Burn Association annual meeting.
The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. (1980)

The platelet binding characteristics of platelet-activating factor (PAF), a basophil-derived lipid that causes aggregation and secretion in rabbit platelets, were studied. In an assay in which binding was quantitated by loss of PAF activity, suspensions of washed rabbit platelets rapidly removed PAF from solution. Rabbit erythrocytes, lymphocytes, and neutrophils also bound PAF, but their binding capacity was less than that of the platelets. PAF binding to rabbit platelets was saturable and dependent on temperature and concentration of PAF and platelets but not on the presence of extracellular Ca2+. Initial rates of PAF binding and platelet secretion were identical, although temperature dependence studies suggested that binding was not the rate-controlling step in PAF-induced platelet secretion. Analysis of binding kinetics suggested that a PAF concentrations saturable for platelet secretion, only some of the available platelet binding sites were occupied.
Feline cytokines TNFα AND IL‐1β: PCR cloning and sequencing of cDNA (1992)

Abstract Using oligonucleotide primers and polymerase chain reaction (PCR), cDNAs for feline cytokines TNFα and IL‐1β were amplified, cloned, and sequenced. The cDNA for PCR amplification was prepared from mRNA derived from lipopolysaccharide (LPS) stimulated feline bone marrow derived macrophages. PCR was performed using sets of oligonucleotide primers designed to specifically amplify cDNAs for IL‐1β or TNFα. PCR fragments were cloned into pGEM 3ZF(‐) or pCR 1000 vectors, sequenced and consensus nucleotide sequences reported. The cDNA for feline TNFα had a 98.6% match with coding regions of a genomic clone for feline TNFα which was recently reported (McGraw, 1990). The two feline TNFα clones differ by 8 nucleotide base pair (bp) changes which result in 5 amino acid differences in the predicted protein sequence. A search of GenBank and EMBL determined that the feline TNFα cDNA consensus sequence had a 90, 86, 85, 82 and 83 percent overall match with human, porcine, ovine, mouse and goat TNFα cDNAs, respectively. The protein‐coding sequence for feline TNFα from start to stop codon is 702 bp in length and encodes a predicted protein of 233 amino acids with a molecular weight of approximately 25,446 daltons (precursor form of secreted form of TNFα). The protein‐coding sequence for feline IL‐1β is 804 bp long and encodes a predicted protein of 267 amino acids with a molecular weight of 31,892 daltons (precursor form of secreted IL‐1β). The feline IL‐1β cDNA consensus sequence had an overall match of 79, 76, 77.5 and 77 percent with IL‐1β cDNA from human, bovine, rabbit and murine species, respectively.
Critical Behavior of the Low Temperature Dielectric Constant of Si:As (1987)

Capacitance measurements on insulating uncompensated Si:As have been made to temperatures as low as 10mK from 10Hz to 1MHz. As T→0 C(ω,T) shows very little dispersion from hopping and one obtains the dielectric response ε '(N)- ε h =4π χ '(N). As N→N c -χ'(N)∝(N c /N-1) -ζ and we obtain ζ=1.18±.08 for N c =8.55±.05×10 18 /cm 3 , thus finding ζ=2µ where µ is the DC conductivity exponent. These agree with Si:P results and confirm universality of the exponents and the Mott criterion for n=type Si.
Proppant Settling Velocities in Nonflowing Slurries (1985)

This paper examines the influence of proppant concentration and fracturing fluid rheology on the settling velocity of nonflowing (static) slurries. Static sedimentation behavior is important in proppant transport not only during closure, but also during pumping since a large fraction of the proppant slurry resides in regions of low shear rate.Slurry settling-velocity measurement technology was devised, enabling velocity determinations to be made in simulated vertical fractures at sand concentrations from 0 to 12 pounds per gallon of fluid (lb/gal). Fluids examined included crosslinked and uncrosslinked fracturing fluids, plus a Newtonian fluid. Sedimentation behavior in fracturing fluids was dominated by a particle clustering phenomenon. Settling velocity was found to depend on proppant concentration in a very different manner than generally assumed by proppant transport models. Although all fluids had similar viscosities at typical rheological characterization shear rates, static slurry settling velocities differed by a factor of more than 100. Differences in fluid viscosities at very low shear rates explain the observed diversity of settling velocities.
Oxidative Assimilation of Glucose by Pasteurella Pestis (1969)

Endothelial dysfunction is a common early pathogenic event in patients with type 2 diabetes (T2D) who exhibit cardiovascular disease. In the present study, we have examined the effect of SKA-31, a positive modulator of endothelial Ca(2+)-activated K(+) (KCa) channels, on total coronary flow in isolated hearts from Goto-Kakizaki rats, a non-obese model of T2D exhibiting metabolic syndrome. Total coronary flow and left ventricular developed pressure were monitored simultaneously in isolated, spontaneously beating Langendorff-perfused hearts. Acute administrations of bradykinin (BK) or adenosine (ADO) increased coronary flow, but responses were significantly blunted in diabetic hearts at 10-12 and 18-20weeks of age compared with age-matched Wistar controls, consistent with the presence of endothelial dysfunction. In contrast, SKA-31 dose-dependently (0.01-5μg) increased total coronary flow to comparable levels in both control and diabetic rat hearts at both ages. Flow responses to sodium nitroprusside were not different between control and diabetic hearts, suggesting normal arterial smooth muscle function. Importantly, exposure to a sub-threshold concentration of SKA-31 (i.e. 0.3μM) rescued the impaired BK and ADO-evoked vasodilatory responses in diabetic hearts. Endothelial KCa channel activators may thus help to preserve coronary flow in diabetic myocardium.
Huge malignant localized fibrous tumor of the pleura. (2000)

Localized fibrous tumor is an unfrequent mesenchymal neoplasm. The malignant variant of the pleura is exceptional and differential diagnosis with the more frequent benign type or with other neoplasms such as soft tissue sarcoma and mesothelioma is rarely possible in a preoperative setting. The best treatment of this disease is radical surgical resection. No definitive data exist about the role of chemotherapy. We report a case of a giant right intrathoracic mass whose preoperative diagnosis, from an open biopsy, was consistent with sarcoma and, in a second review, with fibrous tumor of the pleura without any indication about malignancy. A right pleuropneumonectomy and pericardial resection was performed through a right hemiclam-shell approach. Histology demonstrated an aggressive behaviour: high mitosis rate, Ki 67 of 34% and diffuse necrosis were present. In consideration of the apparent local radicality we did not perform any adjuvant treatment. Six months after the operation a wide local recurrence was evident and a systemic treatment with Ifosfamide and Adriamicina is still in progress. So far a good response has been documented. Preoperative diagnosis of malignancy has an important role as a therapeutic strategy in management of fibrous tumours of the pleura. When there is suspicion of a malignant form neoadjuvant chemotherapy can represent a further tool to control poorly differentiated and large tumors, and a wide surgical resection of the lesion must be performed.
Brain activities during synchronized tapping task (2015)

This study aims to investigate how people process information about other people to determine a response during human-to-human cooperative work. As a preliminary study, the mechanism of cooperative work was examined using interaction between a machine and a human. This machine was designed to have an "other person" model that simulates an emotional model of another person. The task performed in the experiment was a synchronized tapping task. Two models were prepared for this experiment, a simple model that does not employ the other person model and a synchronized model that employs the other person model. Subjects performed cooperative work with these machines. During the experiment, brain activities were measured using functional near-infrared spectroscopy. It was observed that the left inferior frontal gyrus was activated more with the synchronized model than the simple model.
20 W cladding-pumped Nd3+-doped fiber laser at 910nm (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Laroche, B. Cadier, H. Gilles, S. Girard, L. Lablonde, and T. Robin, "20 W cladding-pumped Nd3+-doped fiber laser at 910nm," in CLEO: 2013, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper CM4I.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
UNIVERSAL DISPERSION AND BAND-GAP SCALING OF N_2 IN SOLIDS (1991)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. SHEIK-BAHAE, D. C. HUTCHINGS, D. J. HAGAN, and E. W. VAN STRYLAND, "UNIVERSAL DISPERSION AND BAND-GAP SCALING OF N2 IN SOLIDS," Optics & Photonics News 2(12), 22-22 (1991) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Experimental studies of rubidium absolute polarization at high temperatures (1999)

We report on measurements of the absolute rubidium (Rb) polarization, optically pumped by a high-power diode laser array, up to temperatures of 180 °C. The penetration of the pump laser light into a high-pressure cell has been studied experimentally and theoretically. The experimental results are compared to a model, which describes the local Rb polarization and optical pumping rate in the cell.
Chemical and Chemotaxonomical Studies of Ferns. LXXXI. Characteristic Lignans of Blechnaceous Ferns. (1992)

Four lignans, blechnic acid (1), 7-epiblechnic acid (3), 8-epiblechnic acid (6) and brainic acid (2), were isolated from six Blechnaceous ferns, Blechnum orientale, Struthiopteris amabilis, S. niponica, Woodwardia orientalis, W. prolifera and Brainea insignis. Their structures were determined by spectroscopic methods and chemical conversion.
ChemInform Abstract: 6‐METHYLENECYCLOHEXANONE‐2,4‐DICARBOXYLATES FROM THE ANIONS OF SECONDARY AMIDES AND ACRYLATES (1981)

Abstract Acrylsäureester (II) reagieren in Gegenwart der Amide (I) in Form der mit NaH hergestellten Anionen über diskutierte Zwischenstufen zu den Trimerisierungsprodukten (III) neben geringen Anteilen an den Cyclohexenolen (IV) und (V).