gebhart/patrepeval huggingface dataset:
Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk (2004)

Inflammation can predispose to myocardial infarction (MI), and mannan binding lectin (MBL) promotes phagocytic clearance of inflammatory agents, but the predictive value of MBL levels for MI is not known. MBL was analyzed in subgroups of the population-based Reykjavik study, a cohort of 19,381 participants recruited from 1967. MBL levels were very stable over time (self correlation: 0.86). In a cross-sectional group from the original cohort (n = 987), high MBL (>1,000 microg/L) was associated with a greatly lowered odds ratio for MI (0.64, P < 0.001). To verify this finding, a nested case control sample (n = 1,309) was randomly selected from the cohort. High MBL at recruitment was also associated with decreased MI risk in this follow-up group, but to a lesser extent and not significant for the whole group, smokers, or hypertensive individuals. However, high MBL was as in the cross-sectional group, associated with greatly decreased MI risk in diabetic (P = 0.02) or hypercholesterolemic individuals (P = 0.004). This also applied to raised erythrocyte sedimentation rate (P = 0.007). Diabetic patients with high MBL did not have a higher MI risk than nondiabetic individuals. Our findings indicate that high MBL may predict decreased likelihood of MI, particularly in diabetics, and are consistent with the possibility that MBL may promote clearance of atherogenic agents.
4,5-Dihydroblumenol A, a New Nor-isoprenoid from Perrottetia multiflora (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT4,5-Dihydroblumenol A, a New Nor-isoprenoid from Perrottetia multifloraAntonio G. González, José A. Guillermo, Angel G. Ravelo, Ignacio A. Jimenez, and Mahabir P. GuptaCite this: J. Nat. Prod. 1994, 57, 3, 400–402Publication Date (Print):March 1, 1994Publication History Published online1 July 2004Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/np50105a013https://doi.org/10.1021/np50105a013research-articleACS PublicationsRequest reuse permissionsArticle Views564Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Very Fast and Primingless Single-Crystal-Diamond X-Ray Dosimeters (2012)

X-ray dosimeters were developed by tailoring novel injecting diamond-like-carbon/Pt/Au contacts on single-crystal high-purity diamond films. A dark resistivity of (5.6 ± 0.1) × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">14</sup> Ω · cm and no appreciable presence of deep traps in the bandgap confirmed a very low defect density in the diamond films. The dosimeters resulted to be primingless (i.e., no need of preactivation) and characterized by high sensitivity [(58.20 ± 3.26) × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> C · Gy <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> ] and linear response to X-ray dose rate, produced by a molybdenum target. Transient X-ray modulated analysis allowed the determination of fast-trap influence and the estimation of very fast response times (~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> s), at electric fields ≥ 3 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> V/cm.
[Role of glycogen synthase kinase-3β in development of severe hepatitis liver failure caused by hepatitis B virus]. (2016)

GSK3 is activated in the development of SHLF, so it is an important signaling molecule in the pathogenesis of SHLF. Inhibiting its activity may play a role in the prevention and treatment of SHLF.
Wheel running and environmental enrichment differentially modify exon‐specific BDNF expression in the hippocampus of wild‐type and pre‐motor symptomatic male and female Huntington's disease mice (2009)

Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin and regulation of its expression is complex due to multiple 5' untranslated exons which are separately spliced to a common coding exon to form unique mRNA transcripts. Disruption of BDNF gene expression is a key to the development of symptoms in Huntington's disease (HD), a fatal neurodegenerative condition. Abnormal epigenetic modifications are associated with reduced gene expression in late-stage HD but such regulation of BDNF gene expression has yet to be investigated. We hypothesized that BDNF gene expression is altered in the HD hippocampus of pre-motor symptomatic R6/1 transgenic HD mice, correlating with a change in the DNA methylation profile. The effects of wheel-running and environmental enrichment on wild-type mice, in association with a proposed environment-mediated correction of BDNF gene expression deficits in HD mice, were also investigated. Using real-time PCR, levels of total BDNF mRNA were found to be reduced in the hippocampus of both male and female HD mice. Wheel-running significantly increased total BDNF gene expression in all groups of mice except male HD mice. In contrast, environmental enrichment significantly increased expression only in male wild-type animals. Further quantification of BDNF exon-specific transcripts revealed sex-specific changes in relation to the effect of the HD mutation and differential effects on gene expression by wheel-running and environmental enrichment. The HD-associated reduction of BDNF gene expression was not due to increased methylation of the gene sequence. Furthermore, environment-induced changes in BDNF gene expression in the wild-type hippocampus were independent of the extent of DNA methylation. Overall, the results of this study provide new insight into the role of BDNF in HD pathogenesis in addition to the mechanisms regulating normal BDNF gene expression.
Opportunities of synergistically adjusting voltage-frequency levels of cores and DRAMs in CMPs with 3d-stacked DRAMs for efficient thermal control (2016)

Chip-Multiprocessors (CMPs) with 3D-stacked DRAMs is promising for solving the memory wall problem, but the high power density makes 3D ICs frequently operate at or near the thermal limit. System hot spot of a CMP with 3Dstacked DRAMs is usually in DRAMs that are in the layers farthest from the heat sink. Heat from DRAMs and cores are all accumulated in DRAMs. Therefore, existing thermal managements for 3D ICs all perform thermal control on cores only because lowering the power-level of cores can also lower DRAM access frequency. However, as the power consumption of single DRAM access increases with the number of DRAM stacks and the width of the vertical links, the instantaneous DRAM accesses may easily overheat the system. So, in addition to lowering the access frequency of DRAMs, reducing the power consumption per DRAM access is also crucial. In this paper, we characterize the thermal and performance behavior of the target architecture when the voltage and frequency levels of cores and DRAMs are synergistically controlled. We also evaluate the thermal and performance behavior of existing thermal control methods that can be applied to the target architecture. The insights provided by the characterizations presented in this paper are important for developing an effective thermal management policy for CMPs with 3D-stacked DRAMs. Our results show that, synergistically controlling the voltage-frequency levels of cores and DRAMs does achieve higher thermal efficiency than controlling cores only.
[The effect of hyperbaric oxygenation on rat somatic and generative cells]. (1990)

The effect of higher oxygen pressures (0.3 MPa, 5 sessions 1 h each daily) on induction of chromosomal aberrations in somatic cells and germinal tissues of rat males has been studied. Appearance of aberrations in bone marrow cells after HBO was recorded for 3 months, in cells of eye cornea epithelium--during 3 weeks after the end of sessions. Chromosome rearrangements in the first meiotic division were detected only 90 days after sessions. HBO affects neither functional nor morphological conditions of gonads and induces no dominant lethals. It is suggested that mutagenesis in bone marrow cells is an adaptive process, preventing mutagenic consequences of HBO in the cells of germinal tissue.
When will Google's self-driving car really be ready? It depends on where you live and what you mean by "ready" [News] (2016)

If you're one of the millions of people pining to own a Google self-driving car, you'd better make yourself comfortable, because you may be in for a much longer wait than you ever expected. Not only that: There's a distinct chance that once you get behind the wheel of the first commercial version of the Google car, it may not be able to take you where you need to go. Any shift by Google in its self-driving car plans would be significant, because while there have been skeptics, much of the world has taken it for granted that the major technology challenges of fully computer-controlled vehicles have been worked out, and that Google was on track to deliver them in the near future. The expectations are so high that lawmakers are now being urged to scrap support for mass transit programs, which, some argue, won't be needed in an era of ubiquitous self-driving cars.
An Adaptive Content Sharing Protocol for P2P Mobile Social Networks (2010)

In Mobile Social Networks (MSN) users can participate in communication based on their mutual interests. Typical implementations of Social Networks involve client/server architecture where a user needs to subscribe to a server for content sharing with other clients. Popular Online Social Network providers have recently extended the web based service into the mobile domain. However due to mobility and connectivity issues this architecture is in-adequate in providing peer to peer content sharing services to mobile users. Many solutions for Mobile Ad Hoc networks have been proposed however content based communication in partially or intermittently connected MANETs has been a recent research area. In this paper we present an adaptive protocol to facilitate implementation of a Mobile Social Network based on peer to peer content driven communication when end-to-end connectivity is not possible. The proposed protocol takes into account the information about user's interests, content based data storing and forwarding, and host mobility in a disconnected, delay tolerant MANET.
A DAG Task Scheduling Scheme on Heterogeneous Computing Systems Using Invasive Weed Optimization Algorithm (2014)

Efficient task scheduling is crucial to heterogeneous cluster performance. And various scheduling methods based on random search technique have been proposed for both homogeneous and heterogeneous cluster systems. However, most of these methods have high computational overhead and poor convergence. Invasive weed optimization algorithm (IWO) is a novel bionic intelligent optimization algorithm that has fast convergence rate and easier implementation than traditional genetic algorithm (GA) based algorithm. In this paper, an IWO task scheduling (IWOTS) algorithm is proposed for heterogeneous cluster system. To the best of our knowledge, this study is the first time to apply IWO to discrete task scheduling problems. Extensive simulation experiment results show that IWOTS generally exhibits outstanding convergence performance and could produce an optimal scheduling strategy.
Vasicinone. A Bronchodilator Principle from Adhatoda Vasica Nees (N. O. Acanthaceae) (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVasicinone. A Bronchodilator Principle from Adhatoda Vasica Nees (N. O. Acanthaceae)D. R. Mehta, J. S. Naravane, and R. M. DesaiCite this: J. Org. Chem. 1963, 28, 2, 445–448Publication Date (Print):February 1, 1963Publication History Published online1 May 2002Published inissue 1 February 1963https://pubs.acs.org/doi/10.1021/jo01037a041https://doi.org/10.1021/jo01037a041research-articleACS PublicationsRequest reuse permissionsArticle Views403Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding (2007)

Mammalian target of rapamycin (mTOR) functions in two distinct signaling complexes, mTORC1 and mTORC2. In response to insulin and nutrients, mTORC1, consisting of mTOR, raptor (regulatory-associated protein of mTOR), and mLST8, is activated and phosphorylates eukaryotic initiation factor 4E-binding protein (4EBP) and p70 S6 kinase to promote protein synthesis and cell size. Previously we found that activation of mTOR kinase in response to insulin was associated with increased 4EBP1 binding to raptor. Here we identify prolinerich Akt substrate 40 (PRAS40) as a binding partner for mTORC1. A putative TOR signaling motif, FVMDE, is identified in PRAS40 and shown to be required for interaction with raptor. Insulin stimulation markedly decreases the level of PRAS40 bound by mTORC1. Recombinant PRAS40 inhibits mTORC1 kinase activity in vivo and in vitro, and this inhibition depends on PRAS40 association with raptor. Furthermore, decreasing PRAS40 expression by short hairpin RNA enhances 4E-BP1 binding to raptor, and recombinant PRAS40 competes with 4E-BP1 binding to raptor. We, therefore, propose that PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
Scalable Platform for Malicious Content Detection Integrating Machine Learning and Manual Review (2015)

This thesis examines the design, implementation and performance of a scalable analysis platform for the detection of malicious content. To reflect the deployment of actual production systems, we design our platform to explicitly model the passage of time and the involvement of human supervisors in the analysis process. This thesis shows how our platform can operate efficiently at a large scale. The thesis presents and evaluates our platform in the context of a case study focused on malware detection.To model the passage of time while still allowing for batch training methods our platform discretizes time into a series of retraining periods, allowing updated samples and labels to emerge during each period. During each retraining period, our platform combines the presently deployed model with externally available information about newly emerged samples to select samples for submission to a human labeling oracle. To support a large volume of data over successive timeframes, our platform uses advanced techniques to manage the size of data including compression and selective data retention. These operations support efficient feature extraction.Our platform is implemented in Python, allowing use of both the Python scientific stack (Numpy, Scipy, Scikit-Learn) and IPython for interactive, distributed computation. In the interest of scalability our system uses HDFS and Apache Spark to manage distributed data and computation. This thesis discusses our implementation as well as the hardware and software configuration supporting our system.This thesis presents an evaluation of our work using a malware dataset containing over 1 million samples collected over a period of 2.5 years. It begins by characterizing our dataset, including an examination of label shift over time motivating our work. It presents evidence demonstrating that by submitting a small fraction of samples for human review we are able to appreciably increase detection outcomes.We have released our code along with 3% of our case study data, allowing replication of our results on a single node. Note that detection performance will vary due to the decrease in available training data.
Next-generation optical networks as a value creation platform (2003)

In this article we discuss the role of the next-generation optical networks and introduce enabling technologies that support network evolution. The role of networks is undergoing change and is becoming a platform for value creation. In addition to providing new services, networks have to accommodate steady traffic growth and guarantee profitability. We envision a next-generation optical network as the combination of an all-optical core and an adaptive shell operated by intelligent control and management software suites. Possible technological innovations are introduced in devices, transmission technologies, nodes, and networking software, which will contribute to attain a flexible and cost-effective next-generation optical network. New values will be created by the new services provided through these networks, which will change the ways we do businesses and go about our private lives.
InTouch 8 (3) (2003)

This is a newsletter of the World Bank country office Manila. This issue features: Mindanao Working Group acts to reach consensus. Donors support Government economic program. Faster implementation of WB-Assisted projects cited. The new recruits : two women, two men talk personal : Jose Eric Maglanque, Florence Tienzo, Maria Luisa Badua, and Ernesto Diaz. Philippine Gov't receives U$S 10.6 million for phase-out of ozone-depleting CFC's.
IN rollout in Europe (1993)

The present situation related to intelligent networks (INs) in Europe is described. The projects and experiences of some single operators and main aspects of a joint initiative research activity currently carried out by various European countries (Eurescom) are discussed. In particular, the status of IN in the Italian SIP network, in the United Kingdom BT network, and in the France FT network is reviewed. Particular reference is made to the basic milestones of the IN project, the architectural approach adopted, the services provided, and the planned evolution. The objectives, the tasks, and the activities performed within the European group are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An adaptive system for the estimation of the magnetotelluric impedance tensor and its application in earthquake prediction (1992)

This paper presents an adaptive system for modelling the tensor Z which relates the Earth's electric E and magnetic H field components, and the application of this system in earthquake prediction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells <i>in vivo</i> (2008)

The pathways that allow quiescent disseminated cancer cells to survive during prolonged dormancy periods are unknown. Here, we identify the transcription factor ATF6alpha as a pivotal survival factor for quiescent but not proliferative squamous carcinoma cells. ATF6alpha is essential for the adaptation of dormant cells to chemotherapy, nutritional stress, and, most importantly, the in vivo microenvironment. Mechanism analysis showed that MKK6 and p38alpha/beta contribute to regulating nuclear translocation and transcriptional activation of ATF6alpha in dormant cancer cells. Downstream, ATF6alpha induces survival through the up-regulation of Rheb and activation of mTOR signaling independent of Akt. Down-regulation of ATF6alpha or Rheb reverted dormant tumor cell resistance to rapamycin and induced pronounced killing only of dormant cancer cells in vivo. Knocking down ATF6alpha also prolonged the survival of nude mice bearing dormant tumor cells. Targeting survival signaling by the ATF6alpha-Rheb-mTOR pathway in dormant tumor cells may favor the eradication of residual disease during dormancy periods.
Coherence-Pattern Guided Compressive Sensing with Unresolved Grids (2011)

Highly coherent sensing matrices arise in discretization of continuum imaging problems such as radar and medical imaging when the grid spacing is below the Rayleigh threshold. Algorithms based on techniques of band exclusion (BE) and local optimization (LO) are proposed to deal with such coherent sensing matrices. These techniques are embedded in the existing compressed sensing algorithms such as Orthogonal Matching Pursuit (OMP), Subspace Pursuit (SP), Iterative Hard Thresholding (IHT), Basis Pursuit (BP) and Lasso, and result in the modified algorithms BLOOMP, BLOSP, BLOIHT, BP-BLOT and Lasso-BLOT, respectively. Under appropriate conditions, it is proved that BLOOMP can reconstruct sparse, widely separated objects up to one Rayleigh length in the Bottleneck distance {\em independent} of the grid spacing. One of the most distinguishing attributes of BLOOMP is its capability of dealing with large dynamic ranges. The BLO-based algorithms are systematically tested with respect to four performance metrics: dynamic range, noise stability, sparsity and resolution. With respect to dynamic range and noise stability, BLOOMP is the best performer. With respect to sparsity, BLOOMP is the best performer for high dynamic range while for dynamic range near unity BP-BLOT and Lasso-BLOT with the optimized regularization parameter have the best performance. In the noiseless case, BP-BLOT has the highest resolving power up to certain dynamic range. The algorithms BLOSP and BLOIHT are good alternatives to BLOOMP and BP/Lasso-BLOT: they are faster than both BLOOMP and BP/Lasso-BLOT and shares, to a lesser degree, BLOOMP's amazing attribute with respect to dynamic range. Detailed comparisons with existing algorithms such as Spectral Iterative Hard Thresholding (SIHT) and the frame-adapted BP are given.