gebhart/patrepeval huggingface dataset:
IFNγ-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells (2010)

IL-6 has pro- and anti-inflammatory effects and is involved in endothelial cell (EC) dysfunction. The anti-inflammatory effects of IL-6 are mediated by signal transducer and activator of transcription-3 (STAT3), which is importantly controlled by suppressor of cytokine signaling 3 (SOCS3). Therefore, cytokines that modulate SOCS3 expression might inhibit the anti-inflammatory effects of IL-6. We hypothesized that in EC, interferon-gamma (IFNgamma)-induced SOCS3 expression leads to inhibition of IL-6-induced STAT3 activation and IL-6-dependent expression of anti-, but not pro-inflammatory, target genes. IFNgamma activated STAT1 and STAT3 and increased SOCS3 expression in EC. IL-6 only activated STAT3 and induced SOCS3 expression. IFNgamma pretreatment of EC inhibited IL-6-induced STAT3 activation accompanied by increased SOCS3 protein. Inhibition of SOCS3 expression, using costimulation, Act-D, and small interfering RNA (siRNA), subsequently implicated the importance of IFNgamma-induced SOCS3 in this phenomenon. Pretreatment of EC with IFNgamma also affected the transcriptional program induced by IL-6. We identified 1) IL-6 anti-inflammatory target genes that were inhibited by IFNgamma, 2) IFNgamma-target genes of pro-inflammatory nature that were increased in response to IL-6 in the presence of IFNgamma, and 3) a set of target genes that were increased upon IL-6 or IFNgamma alone, or combined IFNgamma and IL-6. In summary, by increasing SOCS3 expression in EC, IFNgamma can selectively inhibit STAT3-dependent IL-6 signaling. This in turn leads to decreased expression of some EC protective genes. In contrast, other genes of pro-inflammatory nature are not inhibited or even increased. This IFNgamma-induced shift in IL-6 signaling to a pro-inflammatory phenotype could represent a novel mechanism involved in EC dysfunction.
Do we know the Th1/Th2/Th17 determinants of vaccine response? (2012)

EVALUATION OF: Kamath AT, Mastelic B, Christensen D et al. Synchronization of dendritic cell activation and antigen exposure is required for the induction of Th1/Th17 responses. J. Immunol. 188(10), 4828–4837 (2012).The determinants of Th1/Th2/Th17 responses elicited by vaccine formulations are largely undefined and are an intense area of research. Most of the present licensed alum-adjuvanted subunit vaccines fail to elicit Th1/Th17 immune responses, and Th2 antibody responses are weak and often require repeated immunizations. Moreover, such responses are not sufficient for eliminating intracellular pathogens. Th1 responses have been traditionally elicited by live-attenuated, vector-based or Toll-like receptor ligand-adjuvanted formulations for optimal stimulation of the innate immune system and immunomodulation. The linkage of adjuvant and antigen (Ag) physically, and/or in a formulation, is essential to overcome systemic effects of the adjuvant and elicit Th1/Th17 responses. The role of delivery systems for codelivery of adjuvant and Ag to the same dendritic cell has gained acceptance. The milieu in which dendritic cells process and present Ag to naive CD4+ T cells determines their polarization into different subsets.
Rapid solidification technology (1983)

Rapid solidification technology , Rapid solidification technology , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Retina Verification System Based on Biometric Graph Matching (2013)

This paper presents an automatic retina verification framework based on the biometric graph matching (BGM) algorithm. The retinal vasculature is extracted using a family of matched filters in the frequency domain and morphological operators. Then, retinal templates are defined as formal spatial graphs derived from the retinal vasculature. The BGM algorithm, a noisy graph matching algorithm, robust to translation, non-linear distortion, and small rotations, is used to compare retinal templates. The BGM algorithm uses graph topology to define three distance measures between a pair of graphs, two of which are new. A support vector machine (SVM) classifier is used to distinguish between genuine and imposter comparisons. Using single as well as multiple graph measures, the classifier achieves complete separation on a training set of images from the VARIA database (60% of the data), equaling the state-of-the-art for retina verification. Because the available data set is small, kernel density estimation (KDE) of the genuine and imposter score distributions of the training set are used to measure performance of the BGM algorithm. In the one dimensional case, the KDE model is validated with the testing set. A 0 EER on testing shows that the KDE model is a good fit for the empirical distribution. For the multiple graph measures, a novel combination of the SVM boundary and the KDE model is used to obtain a fair comparison with the KDE model for the single measure. A clear benefit in using multiple graph measures over a single measure to distinguish genuine and imposter comparisons is demonstrated by a drop in theoretical error of between 60% and more than two orders of magnitude.
A Context-Aware Services Development Model (2012)

Currently the context models focus more on the expression ability rather on the automatic deployment and execution capability. Also a context aware platform is required to support the modeling and automatic deployment and execution of the context aware system. This paper aims to build an executable context model and define the architecture of the context aware system as well. Firstly a context-aware services development model is proposed. And then the architecture of the context-aware system is defined. The lifecycle of such system includes two phase, namely design phase and running phase. In service design phase, the development model can describe user's context, situation, and services' configuration information. While in running phase, the execution engine can build the instances of a model and navigating the execution of the model, namely, receive the context changing events, manage the user's Scene transitions and invoke the context-aware services according to the scene's configuration. In addition the model is exemplified with an elder health monitoring model.
Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents (2013)

Hepatocyte nuclear factor 4 alpha (HNF4α), the master regulator of hepatocyte differentiation, has been recently shown to inhibit hepatocyte proliferation by way of unknown mechanisms. We investigated the mechanisms of HNF4α-induced inhibition of hepatocyte proliferation using a novel tamoxifen (TAM)-inducible, hepatocyte-specific HNF4α knockdown mouse model. Hepatocyte-specific deletion of HNF4α in adult mice resulted in increased hepatocyte proliferation, with a significant increase in liver-to-body-weight ratio. We determined global gene expression changes using Illumina HiSeq-based RNA sequencing, which revealed that a significant number of up-regulated genes following deletion of HNF4α were associated with cancer pathogenesis, cell cycle control, and cell proliferation. The pathway analysis further revealed that c-Myc-regulated gene expression network was highly activated following HNF4α deletion. To determine whether deletion of HNF4α affects cancer pathogenesis, HNF4α knockdown was induced in mice treated with the known hepatic carcinogen diethylnitrosamine (DEN). Deletion of HNF4α significantly increased the number and size of DEN-induced hepatic tumors. Pathological analysis revealed that tumors in HNF4α-deleted mice were well-differentiated hepatocellular carcinoma (HCC) and mixed HCC-cholangiocarcinoma. Analysis of tumors and surrounding normal liver tissue in DEN-treated HNF4α knockout mice showed significant induction in c-Myc expression. Taken together, deletion of HNF4α in adult hepatocytes results in increased hepatocyte proliferation and promotion of DEN-induced hepatic tumors secondary to aberrant c-Myc activation.
Modulation of thiopurine cytotoxicity in the HL-60 cell line by physiological concentrations of hypoxanthine. (1986)

Thioguanine and mercaptopurine are clinically important agents in widespread use for the treatment of acute leukemia. In this study the effect of low, physiological concentrations of hypoxanthine on thiopurine cytotoxicity was examined in the HL-60 human acute promyelocytic leukemia cell line. Initially the effect of cell concentration on medium hypoxanthine levels was investigated. When 10(5) to 10(6) cells/ml were used, medium hypoxanthine concentrations fell to undetectable (less than 0.1 microM) levels by 24 h, due to cell utilization. However, when the cell density was reduced to 10(3) cells/ml, it was possible to maintain a medium hypoxanthine level as low as 0.5 microM for 24 h without significant hypoxanthine depletion. This allowed for the investigation of the extent to which physiological concentrations of hypoxanthine (1.0 to 10 microM) could modulate thiopurine cytotoxicity. HL-60 cells were incubated in medium containing from 1.0 to 100 microM hypoxanthine concentrations and varying levels of thioguanine or mercaptopurine for 24 h. Cells were then washed and cloned in soft agar. Physiological concentrations of hypoxanthine (1.0 to 10 microM) provided significant protection to HL-60 cells from the cytotoxic effects of both thioguanine and mercaptopurine. An increase in medium hypoxanthine level from 1.0 to 3.0 microM resulted in a 3-fold increase in the thiopurine concentration required to kill 50% of cells. There was a linear relationship between the thiopurine concentration required to reduce clonogenic survival by 50% and medium hypoxanthine level over the hypoxanthine concentrations studied. Although thioguanine was 200-fold more potent than mercaptopurine, and an analogue of guanine rather than hypoxanthine, there was a similar degree of modulation of the cytotoxicity of both agents by hypoxanthine. These results indicate that low, physiological hypoxanthine concentrations can significantly modulate thiopurine cytotoxicity and suggest that endogenous hypoxanthine pools may have an important effect on the clinical activity of thioguanine and mercaptopurine.
Model-Driven and Pattern-Based Integration of Process-Driven SOA Models (2006)

Service-oriented architectures (SOA) are increasingly used in the context of business processes. However, the modeling approaches for process-driven SOAs do not yet sufficiently integrate the various kinds of models relevant for a process-driven SOA – ranging from process models to software architectural models to software design models. We propose to integrate process-driven SOA models via a model-driven software development approach that is based on proven practices documented as software patterns. We introduce pattern primitives as an intermediate abstraction to formally model the participants in the solutions that patterns convey. To enable model-driven development, we develop domain-specific modeling languages for each kind of process-driven SOA model - based on formal meta-models that are extended with the pattern primitives. The various process-driven SOA models are integrated in a model-driven tool chain via the meta-models. Our tool chain validates the process-driven SOA models with regard to the constraints given by the meta-models and primitives.
NOVEMBER (2011)

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Programming model for concept learning and its solution based on genetic algorithms (2002)

Learning from examples is an important branch of inductive learning, and is also the bottleneck in concepts extraction of machine learning. Based on inductive learning theory this paper applies combinatorial optimization method to setup the programming models of learning concepts of the prepositional logic formulas in the conjunctive normal form (CNF) and disjunctive normal form (DNF). Then, genetic algorithms (GA), specified to CNF learning, is designed. GA can find the multiple optimal solution in theory and practice, and experiments reveal that it runs more efficiently compared with heuristic algorithms of the generalisation-and-specialisation (GS) type.
Archetype-Based Semantic Integration and Standardization of Clinical Data (2006)

One of the basic needs for any healthcare professional is to be able to access to clinical information of patients in an understandable and normalized way. The lifelong clinical information of any person supported by electronic means configures his/her Electronic Health Record (EHR). This information is usually distributed among several independent and heterogeneous systems that may be syntactically or semantically incompatible. The Dual Model architecture has appeared as a new proposal for maintaining a homogeneous representation of the EHR with a clear separation between information and knowledge. Information is represented by a Reference Model which describes common data structures with minimal semantics. Knowledge is specified by archetypes, which are formal representations of clinical concepts built upon a particular Reference Model. This kind of architecture is originally thought for implantation of new clinical information systems, but archetypes can be also used for integrating data of existing and not normalized systems, adding at the same time a semantic meaning to the integrated data. In this paper we explain the possible use of a Dual Model approach for semantic integration and standardization of heterogeneous clinical data sources and present LinkEHR-Ed, a tool for developing archetypes as elements for integration purposes. LinkEHR-Ed has been designed to be easily used by the two main participants of the creation process of archetypes for clinical data integration: the Health domain expert and the Information Technologies domain expert.
Characterization of helical structures in gelatin networks and model polypeptides by circular dichroism (2007)

Reversible physical crosslinks (junction zones) in gelatin gels and films are thought to consist of triple helical collagen-like structures, however other structures may also occur. In an attempt to understand the relation between the material properties and the various junction structures and their abundance, we characterized these structures using circular dichroism (CD) as a function of the conditions applied. It appeared that the commonly used reference CD spectra for random coil and 31 helix could not be used to deconvolute the spectra observed for gelatin. Most probably, the commonly-used random coil reference spectra do not really reflect unordered structure, while the random coil reference based on the cationic form of polyLysine actually reflects a clear helicity. Denatured gelatin of collagen were found to be better approximations of an unordered polypeptide structure. The prolyl chromophore was shown to have a pronounced influence on the shape and position of the CD spectra. Thus, it was concluded that only polypeptides with the appropriate prolyl content can be used as references, while analysing the relative secondary structure contents by CD. By using temperature-dependent CD, we were able to discern multiple and single helical structures at high and low gelatin concentrations, respectively, by the observed cooperativity of helix-to-coil transition.
Fourier Analysis of Time Series: An Introduction (1977)

Fitting Sinusoids. The Search for Periodicity. Harmonic Analysis. The Fast Fourier Transform. Examples of Harmonic Analysis. Complex Demodulation. The Spectrum. Some Stationary Time Series Theory. Analysis of Multiple Series. Further Topics. References. Indexes.
Environmental risk factors of childhood asthma in urban centers. (1995)

Asthma morbidity and mortality are disproportionately high in urban centers, and minority children are especially vulnerable. Factors that contribute to this dilemma include inadequate preventive medical care for asthma management, inadequate asthma knowledge and management skills among children and their families, psychosocial factors, and environmental exposure to allergens or irritants. Living in substandard housing often constitutes excess exposure to indoor allergens and pollutants. Allergens associated with dust mites (DM) and cockroaches (CR) are probably important in both onset and worsening of asthma symptoms for children who are chronically exposed to these agents. Young children spend a great deal of time on or near the floor where these allergens are concentrated in dust. Of children (2 to 10 years of age) living in metropolitan Washington, DC, 60% were found to be sensitive to CR and 72% were allergic to DM. Exposure to tobacco smoke contributes to onset of asthma earlier in life and is a risk factor for asthma morbidity. Since disparity of asthma mortality and morbidity among minority children in urban centers is closely linked to socioeconomic status and poverty, measures to reduce exposure to environmental allergens and irritants and to eliminate barriers to access to health care are likely to have a major positive impact. Interventions for children in urban centers must focus on prevention of asthma symptoms and promotion of wellness.
Hybrid-mode analysis of homogeneously and inhomogeneously doped low-loss slow-wave coplanar transmission lines (1991)

A hybrid-mode analysis is presented to characterize the propagation properties of uniplanar slow-wave MIS (metal-insulator-semiconductor) coplanar transmission lines. The effect of homogeneous versus gradually inhomogeneous doping profile is investigated as well as the influence of the metal conductor losses and finite metallization thickness on the slow-wave factor and the overall losses. Numerical results indicate that thick-film MIS CPWs can support a slow-wave mode with moderate loss up to 40 GHz when the line dimensions are kept in the micrometer range. Furthermore, it is found that an inhomogeneous doping profile can reduce the overall losses and that the effect of metal conductor losses in heavily doped MIS structures is only marginal. On the other hand, in weakly doped or insulating GaAs material a lossy metal conductor leads to a higher propagation constant, exhibiting a negative slope with increasing frequency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Maximum Permissible Ambient Noise and Frequency-specific Averaging Time on the Measurement of Distortion Product Otoacoustic Emissions (1999)

The effects of ambient noise and averaging time on distortion product otoacoustic emission (DPOAE) measurements were systematically examined in 20 normally hearing adults. For each frequency from 0.7 to 6 kHz, 2f1-f2 DPOAEs were measured at nine intensity levels of ambient noise for each of four different averaging times. The dependent variable of interest was the DPOAE:noise ratio (D:N)--the relationship between DPOAE amplitude and noise level at 2f1-f2. Findings indicated that, relative to the baseline condition (25 dBA), ambient noise levels of 40 dBA or greater affected the D:N considerably in the lower frequencies. However, noise levels of 55-65 dBA did not affect the D:N in the higher frequencies. Results also indicated that, to achieve detectable DPOAEs, longer averaging times were required as ambient noise increased and as frequency decreased. Based on the results, the maximum permissible ambient noise levels (MPANLs) were estimated in relation to averaging time.
Aerodynamic Shape Optimization Of A Vertical Axis Wind Turbine (2011)

The purpose of this study is to introduce and demonstrate a fully automated process for optimizing the airfoil cross-section of a vertical axis wind turbine (VAWT). The objective is to maximize the torque while enforcing typical wind turbine design constraints such as tip speed ratio, solidity, and blade profile. By fixing the tip speed ratio and solidity of the wind turbine, there exists an airfoil cross-section for which the torque can be maximized, requiring the development of an iterative design system.The design system required to maximize torque incorporates rapid geometry generation and automated hybrid mesh generation tools with viscous, unsteady computational fluid dynamics (CFD) simulation software. The flexibility and automation of the modular design and simulation system allows for it to easily be coupled with a parallel differential evolution algorithm used to obtain an optimized blade design that maximizes the efficiency of the wind turbine.
Retraction Note: Behavior Analysis on the Security Object of the Public Rental Housing (2015)

The Publisher and Editor have retracted this article [1] in accordance with good ethical practices. After a thorough investigations we believe that the peer review process was compromised. The article was published on-line on 15-09-2015.
Joint Wireless Positioning by Base Stations and Road Side Units for 5G Advanced (2022)

In current wireless positioning systems, the positioning accuracy may be unsatisfactory under certain scenarios where only base stations (BSs) are utilized for such tasks. To improve the positioning accuracy, this paper proposes to jointly use BSs and the road side units (RSUs) to localize target user equipments (UEs). Firstly, we establish a unified architecture for joint positioning by BSs and RSUs, which empowers harmonized transmission of positioning reference signals by both BSs and RSUs. Besides, the configuration of the sidelink positioning reference signal (SL-PRS) resource is designed for the RSU, which facilitates the improvement of positioning accuracy. Simulation results of wireless positioning with BSs and RSUs confirm that the proposed solution is effective and the positioning accuracy based on both BSs and RSUs outperforms the accuracy based on BSs only.
Age-Related Changes in Left Ventricular Torsion Assessed by 3-Dimensional Ultrasound Speckle Tracking Imaging (2012)

Background: It is increasingly accepted that aging results in changes in left ventricular (LV) structure and function, which may play an important role in the development and progression of cardiovascular diseases. The application of 3-dimensional speckle tracking echocardiography (3D-STE) for evaluation of LV function has not been widely studied, and few data on its use for assessment of cardiac strain and torsional change with aging exist. The purpose of this study was to establish the normal values of LV torsion in healthy persons and to examine the effects of aging on these values using 3D-STE.Methods: Echocardiographic examinations were performed on 87 healthy volunteers who were divided into 3 age groups: young (20-40 years, 30 patients), middle-aged (41-59 years, 31 patients), and elderly (≥60 years, 26 patients). For the apical 3D volumetric images, torsion was analyzed in 16 myocardial segments. Using commercially available 3-dimensional torsion analysis software, time-domain speckle tracking was performed and mean values of torsion were assessed.Results: There were no statistically significant differences in body height, weight, heart rate, blood pressure, or ejection fractions between the 3 groups. A comparison of the global values of rotation, twist, and torsion revealed no differences between the 3 groups. However, regional differences were found among basal, middle, and apical segments; moreover, apical twist and apical torsion increased with age (p ＜ 0.05).Conclusions: The newly developed 3D-STE technique appears to be a reliable tool for assessment of LV regional and global function. This methodology could be applied clinically to assess alterations of myocardial function by accurately measuring regional and global LV torsion and the changes in regional heterogeneity in systolic function seen with increasing age. Our findings imply that regional function parameters may be more sensitive than global function parameters for evaluating systolic function. These results may be of value as reference data for healthy adults in further clinical studies.