gebhart/patrepeval huggingface dataset:
Plasma bradykinin levels in human chronic congestive heart failure (2000)

Induction of congestive heart failure by high-frequency pacing has been reported to increase plasma levels of immunoreactive kinins in dogs. In the present study, we evaluated plasma bradykinin levels in human heart failure. Utilizing a recently developed method, we specifically measured plasma levels of bradykinin-(1-9) nonapeptide in 21 patients with chronic congestive heart failure [New York Heart Association (NYHA) stages III and IV). At the same time, we measured plasma atrial natriuretic peptide levels and plasma renin activity, and, as a marker of inflammation, plasma levels of tumour necrosis factor. In addition, 18 healthy subjects matched for gender and age served as normal controls. Plasma bradykinin concentrations were not higher in patients with chronic congestive heart failure (median 2.1 fmol/ml) than in healthy subjects (2.6 fmol/ml). In contrast, plasma atrial natriuretic peptide levels were clearly higher (patients, 63 fmol/ml; controls, 24 fmol/ml; P<0.0001), despite diuretic treatment and in the presence of high plasma renin activity (patients, 13.0 ng x h(-1) x ml(-1); controls, 0.3 ng x h(-1) x ml(-1); P<0.0001). Tumour necrosis factor was elevated in heart failure patients in NYHA class IV only (27 pg/ml, compared with 21 pg/ml in controls; P=0.013). Bradykinin, atrial natriuretic peptide and plasma renin activity levels were not correlated with the severity of the disease, as assessed by NYHA classification. These results indicate that a rather selective cytokine activation, without concomitant stimulation of the kallikrein-kinin system, occurs in human chronic congestive heart failure.
Endoscopic Parathyroidectomy by a Gasless Approach (1998)

Endoscopic approach for the treatment of primary hyperparathyroidism is one of the new fields of interest for minimally invasive surgery. The removal of the parathyroid gland can be achieved either by a gas or gasless technique. Massive carbon dioxide (CO2) diffusion and absorption has been reported to occur during the gas procedure. Endoscopic techniques that do not rely on CO2 insufflation have still to be set. We have developed a new procedure that was offered to 20 selected patients with a localized parathyroid adenoma. A 3-minute CO2 insufflation (12 mm Hg) through a conventional trocar inserted under the strap muscles is used just to anatomically dissect the virtual thyrotracheal groove. Actually, the working space is maintained by means of skin retractors so as to allow needlescopic instruments to perform a parathyroid adenomectomy with the gasless procedure. In all cases the parathyroid adenoma was removed through a 1.5-cm skin incision. Quick parathyroid hormone assays always confirmed the removal of all pathologic glands and permitted unilateral cervical exploration. Mean operative time was 71.7 +/- 35.5 minutes. No complication was registered. At follow-up, all patients were normocalcemic. This new endoscopic approach to the neck seems to be safe, effective, and cosmetically satisfactory.
Estimation of Rumen Undegradable Protein in Forages by Using Neutral Detergent Insoluble Nitrogen at a Single In Situ Incubation Time Point (2003)

Neutral detergent insoluble nitrogen (NDIN) was used as a direct estimate of UIP. Forage samples collected from upland range and subirrigated meadow sites over the summer were incubated in situ for a time equivalent to a mean retention time estimated from the digestibility of the forage plus 10 hour to account for a lag in passage of particles from the rumen. Samples also were incubated for 75% of the estimated total mean retention time. The UIP values obtained from the fractional rates of degradation and passage were highly correlated with those estimated from samples incubated for 75% of total mean retention time while incubating the samples longer tended to underestimate the UIP fraction.
Preparation of Quinoline Hexose Analogues as Novel Chloroquine‐Resistant Malaria Treatments. Part 1. Synthesis of 4‐Hydroxyquinoline‐β‐glucosides. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Surveillance system with mega-pixel scalable transcoder (2007)

This paper presents a video surveillance system that displays mega-pixel streams effectively, while transmitting and processing the streams efficiently with limited resources such as bandwidth, computing power and display resolution. The proposed system stores high-resolution and high-quality video data and associated object metadata, which includes ROI (Region-of-Interest) information. To satisfy such resource constraints and display important parts in detail without missing the overall scene context, the stored images are efficiently transcoded in the compressed-domain based on the ROI information, display resolution and available bandwidth. Simulation results confirm the effectiveness of the proposed system in terms of objective measures and subjective evaluation.
Fusion of<i>Saccharomyces Uvarum</i>with<i>Saccharomyces Cerevisiae:</i>Genetic Manipulation and Reconstruction of a Brewer's Yeast (1980)

Genetic manipulation of brewer's yeast is hampered by the yeast's inability to mate, low frequency of sporulation, and poor spore viability—all of which are partly because of its polyploid or aneuploid consititution. In the present study, we introduced genetic markers into a brewing strain of Saccharomyces uvarum by conventional mutagenic procedures and then crossed the marked strain with auxotrophic S. cerevisiae haploids, using spheroplast fusion. Fusion of the auxotrophic brewing strain with an a mating type S. cerevisiae produced hybrids that were nonsporulating and nonmating when tested with a and α tester strains. Fusion of the same brewing strain with an α mating type S. cerevisiae produced hybrids that were nonmaters but sporulated well, producing principally four-spored asci of high viability. Tetrad analyses of three hybrids recovered from the latter fusion proved that karyogamy had occurred. Asci from two of these hybrids showed regular segregation of all markers, including mating type. The third hybrid, however, exhibited regular segregation in only four of 18 asci dissected and had from one to three nonviable spores in the remaining 14; of these, seven single ascospores did not mate but sporulated. Genetic data, as well as DNA analyses, were used to estimate ploidy. Haploid ascospores were used to construct triploid brewing strains carrying 0, 1, 2, or 3 maltose genes using spheroplast fusion and conventional mating techniques. These triploid strains exhibited a gene dosage effect with respect to fermentation rate corresponding to the number of maltose genes present in each. These results suggest a model for the construction of genetically improved brewing strains.
Treatment planning in Cobalt‐60 radiotherapy using computerized tomography techniques (1978)

Cobalt-60 transmission measurements were made through an Alderson phantom utilizing a transverse axial tomographic device and a NaI (Tl) detector. Measurements were made on different sections of the phantom for as many as 162 angles and 120 linear increments. The attenuation coefficients were reconstructed using both convolution and algebraic reconstruction techniques. Three-dimensional isodose distributions were obtained using the reconstructed attenuation coefficients. Comparison with standard treatment plans and measured isodose distribution using TLD techniques suggest that a more accurate isodose distribution may be obtained using the reconstructed attenuation coefficients, particularly in regions involving tissue heterogeneities.
BAP1 Missense Mutation c.2054 A>T (p.E685V) Completely Disrupts Normal Splicing through Creation of a Novel 5’ Splice Site in a Human Mesothelioma Cell Line (2015)

BAP1 is a tumor suppressor gene that is lost or deleted in diverse cancers, including uveal mela¬noma, malignant pleural mesothelioma (MPM), clear cell renal carcinoma, and cholangiocarcinoma. Recently, BAP1 germline mutations have been reported in families with combinations of these same cancers. A particular challenge for mutation screening is the classification of non-truncating BAP1 sequence variants because it is not known whether these subtle changes can affect the protein function sufficiently to predispose to cancer development. Here we report mRNA splicing analysis on a homozygous substitution mutation, BAP1 c. 2054 A&T (p.Glu685Val), identified in an MPM cell line derived from a mesothelioma patient. The mutation occurred at the 3rd nucleotide from the 3' end of exon 16. RT-PCR, cloning and subsequent sequencing revealed several aberrant splicing products not observed in the controls: 1) a 4 bp deletion at the end of exon 16 in all clones derived from the major splicing product. The BAP1 c. 2054 A&T mutation introduced a new 5' splice site (GU), which resulted in the deletion of 4 base pairs and presumably protein truncation; 2) a variety of alternative splicing products that led to retention of different introns: introns 14-16; introns 15-16; intron 14 and intron 16; 3) partial intron 14 and 15 retentions caused by activation of alternative 3' splice acceptor sites (AG) in the introns. Taken together, we were unable to detect any correctly spliced mRNA transcripts in this cell line. These results suggest that aberrant splicing caused by this mutation is quite efficient as it completely abolishes normal splicing through creation of a novel 5' splice site and activation of cryptic splice sites. These data support the conclusion that BAP1 c.2054 A&T (p.E685V) variant is a pathogenic mutation and contributes to MPM through disruption of normal splicing.
Isolation and characterization of variant IGF‐1 as well as IGF‐2 from adult human brain (1986)

The forms of somatomedin present in the adult human brain have been characterized in this study. Two peptides were purified by acidification, size exclusion chromatography, affinity chromatography, FPLC and HPLC. Structural analysis identified these peptides as the variant form of IGF-1 with a truncated N-terminal region earlier isolated from human fetal brain and IGF-2. The presence of the truncated IGF-1 variant and IGF-2 in the human CNS suggests their role as neuropeptides.
Analysis of optical-microwave mixing process in electro-optical modulators (2001)

The principle of operation and the general parameters of the electro-optical Mach-Zehnder modulators are reminded in the paper. With the use of the mathematical relationships describing the transmission of the optical signal through the modulator, the theoretical model of the optical signal transmission with two modulating signals at two frequencies will be presented. The theoretical relationships describing the efficiency of the optical-microwave mixing and frequency multiplying in the two-tone operation will be derived. The analysis and the simulations will be performed for different operating points, where the nonlinearity of the transmission characteristic is specially strong.
PROSPECTIVE RANDOMISED CONTROLLED TRIAL ON THE TECHNIQUE OF FACET JOINT INJECTIONS (2006)

Introduction Local steroid injection is commonly performed as a treatment for facet joint arthritis in the lumbosacral spine. The injection is performed under image guidance for which some surgeons utilise antero-posterior (A-P) imaging only while others prefer oblique imaging. The entry point and the direction of the needle entering into the facet joint are different in these techniques. Further the difficulties encountered in both the techniques are different. Purpose To find out the difference in the functional outcome in patients who received the facet joint steroid injection by A-P imaging and those who had the injection by oblique imaging. Material and Methods A prospective randomised controlled trial was performed by randomly allocating the 20 patients who was diagnosed to have facet joint arthritis clinically and by magnetic reasonance image scans, and who were then placed in the list for facet joint injections. Ten patients in Group I received the facet joint injections with A-P imaging while 10 patients in Group II received the facet joint injections with oblique imaging using image intensifier. All the patients received 40mg of methylprednisolone acetate with 1mL of 1% lignocaine and 1mL of 0.5% bupivacaine to each joint. The duration of the entire procedure was noted. Short Form-36 (SF-36) questionnaire was used before the procedure and at six weeks after the procedure to assess the functional outcome. Results All the patients were followed up for a period of six weeks. The mean age was 51.3 yrs in Group I and 48.3 yrs in Group II. The male to female ratio was 3:7 in Group I and 2:5 in Group II. One patient in Group I had the facet injections at only one level (L4/5 or L5/S1) while it was in two patients in Group II. Further one patient in Group I and one in Group two had unilateral facet joint injections at two levels. All the other patients had bilateral facet joint injections at two levels (L4/5 and L5/S1). One patient was excluded from the study as the A-P image obtained was very poor and that an oblique image had to be performed to visualise the facet joint because of obesity. The mean duration of the procedure was 18.33 min (10–25 min) in Group I and 22 min (10–35 min) in Group II (p=0.14, 95%CI −8.5 to +1.4). The patient function score improved from a mean of 20.0% to 32.5% after the injection in Group I, and from 30.0% to 41.0% in Group II. The pain score improved from a mean of 33.3% to 47.2% in Group I, and from 35.6% to 44.4% in Group II. The difference in physical function score (p=0.85, 95% C.I. −15.29 to +18.29), and pain score (p=0.71, 95% C.I. −24.21 to +34.22) between the two groups were not statistically significant. Conclusions There is no difference in the functional outcome of patients treated by facet joint injections using A-P or oblique imaging. However, with experience we found that it may be difficult to visualise the facet joint clearly by A-P imaging alone in obese individuals.
Total Synthesis and Biological Evaluation of (−)-Pectinatone Employing a Methyl-Branched Wax Ester as Key Building Block (2006)

Unnatural (-)-pectinatone ((-)-3) was prepared in five steps starting from the highly methyl-branched wax ester 4, employing bromination of the ester enolate and subsequent base-induced elimination to the enoate 6 as the key step. Both (-)-3 and the amides 8b and 8c, which were isolated as by-products in the reaction sequence, displayed antimicrobial activity and cytotoxicity.
ChemInform Abstract: SELECTIVE TRAPPING OF DIENES BY BENZYLIDENEACETONEIRON TRICARBONYL. SYNTHETIC AND MECHANISTIC STUDIES OF THE REACTIONS OF 1,3,5‐CYCLOOCTATRIENE AND ITS DERIVATIVES WITH BENZYLIDENEACETONEIRON TRICARBONYL (1977)

Abstract Der Benzylidenacetontricarbonyl‐Fe‐ Komplex (III) reagiert mit den labileren Tautomeren, den bicyclischen Dienen (II), (VI) oder (XI), mit denen sich die Triene (I), (V) bzw. (X) im Gleichgewicht befinden und die in geringer Konzentration vorliegen.
MECPerf: An Application-Level Tool for Estimating the Network Performance in Edge Computing Environments (2020)

Edge computing is an emerging architecture in 5G networks where computing power is provided at the edge of the fixed network, to be as close as possible to the end users. Computation offloading, better communication latency, and reduction of traffic in the core network are just some of the possible benefits. However, the Quality of Experience (QoE) depends significantly on the network performance of the user device towards the edge server vs. cloud server, which is not known a priori and may generally change very fast, especially in heterogeneous, dense, and mobile deployments. Building on the emergence of standard interfaces for the installation and operation of thirdparty edge applications in a mobile network, such as the MultiAccess Edge Computing (MEC) under standardization at the European Telecommunications Standards Institute (ETSI), we propose MECPerf, a tool for user-driven network performance measurements. Bandwidth and latency on different network segments are measured and stored in a central repository, from where they can be analyzed, e.g., by application and service providers without access to the underlying network management services, for run-time resource optimization.
Beamforming for IEEE 802.11b using a joint conjugate gradient multistage wiener filter. (2010)

This paper presents a joint reduced rank adaptive beamforming technique using smart antennas that can be applied to systems using direct sequence spread spectrum (DSSS), and we analyze its performance using the IEEE 802.11b signaling standard. The algorithm is based on a joint implementation of the conjugate gradient (CG) multistage Wiener filter (MWF), called the CG-MWF. This algorithm is more robust in a multiuser environment than its single user and full rank counterparts, as well as more efficient to implement, in that it requires a very low rank to adapt the beamformer weights. Multiple signals are assumed, which produce a co-channel interference (CCI) scenario. We show that the algorithm provides up to 7 dB improvement over the single user CG-MWF when the power levels of the users are similar. We demonstrate the robustness of the algorithm under dynamic conditions, such as when the number of users, their powers, and their directions-of-arrival (DoAs) change or when a user is traveling at driving speeds.
Use of a rotating wire cage for retention of animal cells in a perfusion fermentor. (1987)

Separation of cells within a perfused suspension system is still a problem. We modified the rotating steel wire cage described by other researchers (2) for separation of single cells from suspension. The system was mounted to the stirrer shaft of a circular-loop fermenter. After optimization of fermenter design experimental data showed good separation of cells at useful perfusion rates. Data of a 5 l-prototype show with a mammalian tumor cell line a retention rate of better than 95% at a perfusion rate of D = 0.05. Scaling-up studies show a good scaling-up potential and a wide range of possible applications.
RAFT-derived antimicrobial polymethacrylates: elucidating the impact of end-groups on activity and cytotoxicity (2014)

We report the use of RAFT polymerization to obtain eight cationic methacrylate polymers bearing amine or guanidine pendant groups, while varying the R- and Z-RAFT end-groups.
Mass transfer effects on microbial uptake of naphthalene from complex NAPLs (2001)

The above article printed in Biotechnology and Bioengineering without Figures 1–4. We offer on the following pages the article printed in its entirety with Figures 1–4. We apologize for any inconvenience this error may have caused.
Activation of extracellular signal-related kinase by TNF-α controls the maturation and function of murine dendritic cells (2002)

Abstract Functional roles of extracellular signal-related kinase (ERK)activation in dendritic-cell (DC) maturation have been unclear. In thepresent study, we investigated the ERK pathway in tumor necrosis factor(TNF)-α-induced maturation of murine spleen-derived DC. TNF-αincreased surface expressions of major histocompatibility(MHC) and costimulatory molecules on DC in a dose-dependentmanner. High (40 ng/ml) and low (0.4 ng/ml) concentrations of TNF-αmarkedly enhanced ERK1/2 activation in DC, and this activation wasblocked completely by PD98059, a selective inhibitor of the ERKpathway. When DC were treated with TNF-α at a low but not a highconcentration, PD98059 notably enhanced surface expressions of the MHCand costimulatory molecules and allostimulatory capability of the DC. Interleukin (IL)-12 production was enhanced significantly by PD98059 in DC treated with low or high concentration of TNF-α. These findingssuggest that TNF-α-induced ERK activation negatively controlsmaturation and IL-12 production in murine DC.
Literature survey of combustion parameters which characterize the performance of an ethanol engine (1993)

Literature survey of combustion parameters which characterize the performance of an ethanol engine
Selective mode multiplexer based on phase plates and Mach-Zehnder interferometer with image inversion function (2015)

We propose a novel mode multiplexer based on phase plates followed by a Mach-Zehnder interferometer (MZI) with image inversion. After the higher-order modes are selectively converted from fundamental linear-polarized (LP) modes by the phase plates, the converted modes are coupled without fundamental loss using MZI with image inversion, in which the original spatial pattern and inverted pattern of the optical signal are interfered. Our scheme is also applicable to the coupling of degenerated LP modes such as LP(11a) and LP(11b). First, we numerically and experimentally evaluate the performance of the mode converter based on phase plates. The mode converter is suitable as long as the five LP modes such as LP(01), LP(11ab) and LP(21ab) are sustained in a few-mode fiber (FMF), although the crosstalk due to excitation of undesirable modes is unavoidable when the higher-order modes over LP(02) are sustained in FMF. Next, we develop and characterize the proposed mode multiplexers based on phase plates and MZIs with image inversion. The insertion loss is suppressed to around 3 dB for mode multiplexing of LP(11a) and LP(11b). Using a fabricated mode multiplexer for LP(31a) and LP(31b), we measure the bit-error rate performance of single-polarization mode-multiplexed quadrature-phase shift keying optical signals.
Massive machine-type communications in 5g: physical and MAC-layer solutions (2016)

MTC are expected to play an essential role within future 5G systems. In the FP7 project METIS, MTC has been further classified into mMTC and uMTC. While mMTC is about wireless connectivity to tens of billions of machinetype terminals, uMTC is about availability, low latency, and high reliability. The main challenge in mMTC is scalable and efficient connectivity for a massive number of devices sending very short packets, which is not done adequately in cellular systems designed for human-type communications. Furthermore, mMTC solutions need to enable wide area coverage and deep indoor penetration while having low cost and being energy-efficient. In this article, we introduce the PHY and MAC layer solutions developed within METIS to address this challenge.
Schizophrenia Genetics (2011)

Abstract This chapter discusses new developments in the study of schizophrenia conducted by Genomewide Association Studies. Genomewide experiments are bringing about major conceptual changes in the understanding of the genetics of schizophrenia. Their studies show that schizophrenia and bipolar disorder share several characteristics such as peak onset in early adulthood, psychotic symptoms, response to antipsychotic medications, substance use comorbidity, increased suicide risk, and severe mood episodes. The largest family study found familial co-aggregation between schizophrenia and bipolar disorder to be roughly 63% because of additive genetic effects common to both disorders. Schizophrenia and autism also share a few clinical features such as impaired social interaction and communication, and some negative or deficit symptoms. A study of 129 adults with autism spectrum disorders (ASD) found that 7% had psychotic bipolar disorder and 8% had schizophrenia or other psychotic disorders.
Grating lobe characteristics of arrays with uniformly illuminated contiguous subarrays (1983)

This report presents simple approximate formulas and generalized curves to simplify evaluation of the grating lobe levels of various kinds of contiguous subarrays with uniform illumination within each subarray. The cases considered include phase quantization caused by discrete phase shifters, amplitude taper at subarray input ports, and time delay at the subarray input ports. Also, the work is generalized to include certain cases of quantized phase or time delay at the input ports in addition to amplitude taper at subarray input ports. (Author)