Acquired Immune Deficiency Syndrome: The Past as Prologue (1983)

Editorials1 March 1983Acquired Immune Deficiency Syndrome: The Past as PrologueJAMES W. CURRAN, M.D., M.P.H., BRUCE L. EVATT, M.D., DALE N. LAWRENCE, M.D.JAMES W. CURRAN, M.D., M.P.H.Search for more papers by this author, BRUCE L. EVATT, M.D.Search for more papers by this author, DALE N. LAWRENCE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-401 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn June 1981, five cases of Pneumocystis carinii pneumonia in young homosexual men were reported to the Centers for Disease Control (1). Since then, over 1000 definite cases of life-threatening opportunistic infections with or without Kaposi's sarcoma have been reported from 33 states and 13 foreign countries. Recognition that a similar pattern of immune dysfunction underlies each of these conditions resulted in their designation as the acquired immune deficiency syndrome.From the outset, several factors implicated a transmissible agent as the cause of the severe alterations in immune regulation found in the syndrome. These lethal illnesses appeared suddenly and were...References1. . Pneumocystis pneumonia—Los Angeles. Morbid Mortal Weekly Rep. 1981;30:250-2. MedlineGoogle Scholar2. . Epidemic aspects of the current outbreak of Kaposi's sarcoma and opportunistic infections. N Engl J Med. 1982;306:248-52. CrossrefMedlineGoogle Scholar3. HYMESGREENEMARCUS KJA. Kaposi's sarcoma in homosexual men—a report of eight cases. Lancet. 1981;2:598-600. CrossrefMedlineGoogle Scholar4. GOTTLIEBSCHROFFSCHANKER MRH. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N Engl J Med. 1981;305:1425-31. CrossrefMedlineGoogle Scholar5. SIEGALLOPEXHAMMER FCG. Severe acquired immunodeficiency in male homosexuals manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med. 1981;305:1439-44. CrossrefMedlineGoogle Scholar6. MASURMICHELISGREENE HMJ. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N Engl J Med. 1981;305:1431-8. CrossrefMedlineGoogle Scholar7. . A cluster of Kaposi's sarcoma and Pneumocystis carinii pneumonia among homosexual male residents of Los Angeles and Orange Counties, California. Morbid Mortal Weekly Rep. 1982;31:305-7. MedlineGoogle Scholar8. DAVISHORSBURGHHASIBASCHOCKETKIRKPATRICK KCUAC. Acquired immunodeficiency syndrome in a patient with hemophilia. Ann Intern Med. 1983;98:284-6. LinkGoogle Scholar9. ELLIOTTHOPPESPLATTTHOMASPATELGANSER JWMJJA. The acquired immunodeficiency syndrome and Mycobacterium avium-intracellulare bacteremia in a patient with hemophilia. Ann Intern Med. 1983;98:290-3. LinkGoogle Scholar10. POONLANDAYPRASTHOFERSTAGNO MAES. Acquired immunodeficiency syndrome with Pneumocystis carinii pneumonia and Mycobacterium avium-intracellulare infection in a previously healthy patient with classic hemophilia. Ann Intern Med. 1983;98:287-90. LinkGoogle Scholar11. . Pneumocystis carinii pneumonia among persons with hemophilia A. Morbid Mortal Weekly Rep. 1982;31:365-7. MedlineGoogle Scholar12. . Update on acquired immune deficiency syndrome (AIDS) among patients with hemophilia A. Morbid Mortal Weekly Rep. 1982;31:644-52. MedlineGoogle Scholar13. GOLDSMITHMOSELEYMONICKBRADYHUNNINGHAKE JPMMG. T-lymphocyte subpopulation abnormalities in apparently healthy patients with hemophilia. Ann Intern Med. 1983;98:294-6. LinkGoogle Scholar14. KORNFELDVANDE STOUWELANGEREADYGRIECO HRMMM. T-lymphocyte subpopulations in homosexual men. N Engl J Med. 1982;307:729-31. CrossrefMedlineGoogle Scholar15. WORMSERKRUPPHANRAHANGAVISSPIRACUNNINGHAM-RUNDLES GLJGTS. Acquired immunedeficiency syndrome in male prisoners: new insights into an emerging syndrome. Ann Intern Med. 1983;98:297-303. LinkGoogle Scholar16. . Acquired immune deficiency syndrome (AIDS) in prison inmates—New York, New Jersey. Morbid Mortal Weekly Rep. 1982;31:700-1. Google Scholar17. PITCHENIKFISCHLDICKINSON AMG. Opportunistic infections and Kaposi's sarcoma among Haitians: evidence of a new acquired immunodeficiency state. Ann Intern Med. 1983;98:277-84. LinkGoogle Scholar18. . Immunodeficiency among female sexual partners of males with acquired immune deficiency syndrome (AIDS)—New York. Morbid Mortal Weekly Rep. 1983;31:697-8. MedlineGoogle Scholar19. . Possible transfusion-associated acquired immune deficiency syndrome (AIDS)—California. Morbid Mortal Weekly Rep. 1982;31:652-4. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES W. CURRAN, M.D., M.P.H.; BRUCE L. EVATT, M.D.; DALE N. LAWRENCE, M.D.Affiliations: Acquired Immune Deficiency Syndrome Activity and the Host Factors Division Center for Infectious Diseases Centers for Disease Control Atlanta, Georgia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Evolution of the Safety of Plasma Products from Pathogen Transmission—A Continuing NarrativeThe Impact of AIDS on HemophiliaThe Human Immunodeficiency VirusWill killing the last HIV1 particle cure AIDS patients? Doesn't CMV activation and/or a graft-versus-host component of the disease, also have to be considered? I. 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DETSKY, M.D., PH.D.Oncological consequences of impaired immune surveillance against ubiquitous virusesAcquired immune deficiency syndromeProdromal acquired immune deficiency syndrome in Australian homosexual men 1 March 1983Volume 98, Issue 3Page: 401-403KeywordsAIDSHomosexualsImmune deficiencyKaposi sarcomaOpportunistic infectionsPneumocystis carinii pneumonia ePublished: 1 December 2008 Issue Published: 1 March 1983 PDF downloadLoading ...