gebhart/patrepeval huggingface dataset:
Transcriptional collision between convergent genes in budding yeast (2002)

Transcriptional interference between genes and the regulatory elements of simple eukaryotes such as Saccharomyces cerevisiae is an unavoidable consequence of their compressed genetic arrangement. We have shown previously that with the tandem arranged genes GAL10 and GAL7, inefficient transcriptional termination of the upstream gene inhibits initiation of transcription on the downstream gene. We now show that transcriptional interference can occur also with S. cerevisiae RNA polymerase II genes arranged convergently. We demonstrate that when the GAL10 and GAL7 genes are rearranged in a convergent orientation, transcriptional initiation occurs at full levels. However, as soon as the two transcripts begin to overlap, elongation is restricted, resulting in a severe reduction in steady-state mRNA accumulation. This effect is observed only in cis arrangement, arguing against RNA-interference effects acting on the potential generation of antisense transcripts. These data reinforce the necessity of separating adjacent RNA polymerase II transcription units by efficient termination signals.
MinJ (YvjD) is a topological determinant of cell division in <i>Bacillus subtilis</i> (2008)

In Bacillus subtilis, FtsZ ring formation and cell division is favoured at the midcell because the inhibitor proteins MinC and MinD are indirectly restricted to the cell poles by the protein DivIVA. Here we identify MinJ, a topological determinant of medial FtsZ positioning that acts as an intermediary between DivIVA and MinD. Due to unrestricted MinD activity, cells mutated for minJ exhibited pleiotropic defects in homologous recombination, swarming motility and cell division. MinJ restricted MinD activity by localizing MinD to the cell poles through direct protein-protein interaction. MinJ itself localized to cell poles in a manner that was dependent on DivIVA. MinJ is conserved in other low G+C Gram-positive bacteria and may be an important component of cell division site selection in these organisms.
“Native Americans, Neurofeedback, and Substance Abuse Theory”. Three Year Outcome of Alpha/theta Neurofeedback Training in the Treatment of Problem Drinking among Dine' (Navajo) People (1997)

This three year follow-up study presents the treatment outcomes of 19 Dine' (Navajo) clients who completed a culturally sensitive, alpha ltheta neurofeedback training program.I n an attempt to both replicate the earlier positive studies of Peniston (1989) and to determine i f neurofeedback skills would significantly decrease both alcohol consumption and other behavioral indicators of substance abuse, these participants received an average of 40 culturally modijied neurofeedback training sessions.This training was adjunctive to their normal 33 day residential treatment.According to DSM-IV criteria for substance abuse, 4 (21%)participants now meet criteria for "sustained full remission", 12 (63%) for "sustained partial remission", and 3 (16%) still remain "dependent" (American Psychiatric Association, 1994).The majority of participants also showed a significant increase in "level of functioning'!as measured by the DSM-IVAxis V GAF.Subjective reports from participants indicated that their original neurofeedback training had been both enjoyable and self-empowering; an experience generally different from their usual treatment routine of talktherapy and education.This internal training also appeared to naturally stimulate significant, but subtle, spiritual experiences and to be naturally compatible with traditional Navajo cultural and medicine-ways.At the three-year follow-up interview, participants typically voiced that these experiences, and their corresponding insights, had been helpful both i n their ability to cope and in their sobriety.From an outside perspective, experienced nurses also reported unexpected behavioral improvements during the participant's initial training.Additionally, administrators and physicians generally found the objective feedback and verification quality of neurofeedback protocols compatible with their own beliefs.An attempt has also been made to conceptualize the outcome analysis of this study within both a culturally specific and universal socio I bio I environmental context.
Design of connection management module for MOM (2004)

MOM technology has become a key component of an enterprise application server which is usually deployed to process business logics. It has to cope with hundreds or even thousands of concurrent connections at the same time. In this end, the efficient and scalable connection management is required for large scale of clients' requests, and various network transport protocols must be taken into consideration when designing the network module of MOM. To facilitate the full support of PTP (Point-to-Point) and publish/subscribe messaging domains, and group communication service featured by MoIM-Message which is our MOM, this paper proposes three types of primitive messaging operations, synchronous send, synchronous receive, and asynchronous receive, and describes the architecture of transport protocol adapter which can be extended to employee various transport protocols. Those functions are implemented into the Message Transport Layer of our MOM which is designed to have three hierarchical layers. Moreover polling with multiple service thread model that is applied into the socket adapter, is described to cope with the large number of concurrent clients' connections efficiently. To support mobile client platform, we ported the Client Runtime modules into IPaq PDA by utilizing PersonalJava.
(A. E.) Vakalopoulos Ιστορία τοῶ νέου Ελληνισμοῦ. A′. Ἀρχὲς καὶ διαμόρφωσή τον. Thessaloniki: the Author. 1961. Pp. iii + 395. 7 maps. 12 plates. Price not stated. - (A. E.) Vakalopoulos Ἱστορία τοῦ νέου Ἑλληνισμοῦ. B′I. Τουρκοκρατία 1453–1669: οἱ ἱστορικὲς βάσεις τῆς νεοελληνικῆς κοινωνίας καὶ οἰκονομίας. Thessaloniki: the Author. 1964. Pp. xi + 501. 6 maps. 24 plates. Price not stated. - (A. E.) Vakalopoulos Πηγὲς τῆς ἱστορίας τοῦ Νέον Ἑλληισμοῦ. 1. (1204–1669). Thessaloniki: the Author. 1965. Pp. 443. Price not stated. (1968)

(A. E.) Vakalopoulos ̒Ιστορία τοῶ νέου ̒Ελληνισμοῦ. A′. Ἀρχὲς καὶ διαμόρφωσή τον. Thessaloniki: the Author. 1961. Pp. iii + 395. 7 maps. 12 plates. Price not stated. - (A. E.) Vakalopoulos Ἱστορία τοῦ νέου Ἑλληνισμοῦ. B′I. Τουρκοκρατία 1453–1669: οἱ ἱστορικὲς βάσεις τῆς νεοελληνικῆς κοινωνίας καὶ οἰκονομίας. Thessaloniki: the Author. 1964. Pp. xi + 501. 6 maps. 24 plates. Price not stated. - (A. E.) Vakalopoulos Πηγὲς τῆς ἱστορίας τοῦ Νέον Ἑλληισμοῦ. 1. (1204–1669). Thessaloniki: the Author. 1965. Pp. 443. Price not stated. - Volume 88
The Advertising/Marketing Marriage (1974)

Abstract This article evaluates advertising-marketing relationships using marriage as an analog. Client-agency interactions are discussed within the context described by Nena and George O'Neill in their bestseller. Open Marriage. Two types of husband-wife alliances, closed marriage and open marriage, are used comparatively to trace developments in client-agency marriages through the last three decades; the “product era” of the 1950's. the “creative era” of the 1960's and the “position era” of the early 1970's. The article concludes with recommendations to clients and agencies for initiating and achieving open marriages.
Design of a Transceiver RFIC for UWB Chaotic OOK System in 0.18um CMOS Technology (2007)

A transceiver RFIC for ultra wideband (UWB) chaotic on-off keying (OOK) system is designed and verified in 0.18 um CMOS technology. The transceiver RFIC is composed of a quasi-chaotic signal generator, an OOK modulator, a gain-controlled low noise amplifier (GC LNA), an envelop detector, and a baseband variable gain amplifier (VGA). The quasi-chaotic signal generator proposed in this paper is composed of a voltage control oscillator (VCO), a frequency divider, a PN-generator, and an up-conversion mixer. The chip size is 2.4 × 1.2 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The current of the chip is 41 mA at transmit mode and 17 mA at receive mode with a supply voltage of 1.8 V. The result of the loop-back test shows that output signal level of the envelop detector is 200 mVp-p and invariant up-to 1 Mbps data rate.
PILOT: a prescription for program performance measurement (2003)

Application performance measurement and evaluation has developed much more slowly than its sister fields of system performance evaluation and software developments. Progress has been impeded by a shortage of measurement tools designed specifically for programmers, and inadequate detail in the output of existing tools for diagnosing performance problems. The authors propose features that would correct these deficiencies and offer a tool called PILOT to support the claim that a tool embodying those features can be built and would be well received by the software community.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Influence of the Polymerization Step Alone on Oxygen Affinity and Cooperative During Production of Hyperpolymers from Native Hemoglobins with Crosslinkers (1994)

The aim of this study was to find out how the polymerization per se changes oxygen affinity (P50) and cooperativity (n50) of various soluble huge hyperpolymers prepared from native hemoglobins by crosslinking. Increase of cooperativity would be expected considering natural hemoglobin networks. Those hyperpolymers with molecular weights of some 10(6) g/mol are candidates for artificial oxygen-carrying blood additives rather than volume substitutes. Human and bovine hemoglobin reacted with several crosslinkers (2,5-diisothiocyanatobenzenesulfonate (DIBS); 4,4'-diisothiocyanatostilbene-2, 2'-disulfonate (DIDS); 1,3-butadiene diepoxide (BUDE); glutaraldehyde (GDA)) in concentrated (case 1) and diluted (case 2) hemoglobin solutions. With high concentration hyperpolymer and with low concentration only monomer products were obtained. P50 and n50 of the products were determined at pH = 7.4, PCO2 = 40 mmHg, temp. = 37 degrees C. The difference of properties in both cases are regarded as the influence of polymerization per se. Considering this difference we found with almost all combinations of hemoglobin and crosslinker an increase of O2 affinity, with DIBS and DIDS cooperativity was not changed and with BUDE and GDA it was decreased. As compared with native hemoglobin loss of cooperativity is considerable in any combination and condition, but comparing human and bovine hemoglobin the first seems to maintain better cooperativity. In contrast bovine hemoglobin as compared with human hemoglobin maintains better or even decreases its O2 affinity upon reaction with the crosslinkers forming both, monomer and hyperpolymer products, especially in the deoxy state. DIBS and DIDS react very similarly.(ABSTRACT TRUNCATED AT 250 WORDS)
Development of a micromachined epiretinal vision prosthesis (2009)

Microsystems engineering offers the tools to develop highly sophisticated miniaturized implants to interface with the nervous system. One challenging application field is the development of neural prostheses to restore vision in persons that have become blind by photoreceptor degeneration due to retinitis pigmentosa. The fundamental work that has been done in one approach is presented here. An epiretinal vision prosthesis has been developed that allows hybrid integration of electronics on one part of a thin and flexible substrate. Polyimide as a substrate material is proven to be non-cytotoxic. Non-hermetic encapsulation with parylene C was stable for at least 3 months in vivo. Chronic animal experiments proved spatially selective cortical activation after epiretinal stimulation with a 25-channel implant. Research results have been transferred successfully to companies that currently work on the medical device approval of these retinal vision prostheses in Europe and in the USA.
Long-term Correction of β-Thalassemia With Minimal Cellular Requirement and Transplantation Modalities (2007)

Determination of minimal criteria, pre-transplantation regimens, and infusion modalities for effective and reproducible bone marrow (BM) therapy in beta-thalassemia is of fundamental importance for clinical application. In this study, using repopulation assays, we first established the minimal proportion of normal BM stem cells that would result in therapeutic benefit in this red blood cell (RBC) disorder. Eight groups of stable chimeric hemizygous beta-thalassemic (hemi-betathal) mice (10-89%) were systematically subjected to cellular, molecular, and patho-physiologic analyses for approximately 2 years. In the chimeric hemi-betathal groups containing 19-24% normal donor cells, all RBC parameters and consequent erythropoiesis were significantly improved. Mice in the 24% chimeric group and above had marked reduction in organ pathology including iron deposits, and survived to a normal lifespan. Altogether, these results established that a range of 19-24% normal BM cells is sufficient for long-term significant correction of the hemi-betathal phenotype. We also determined concomitantly the minimal myelosuppression radiation doses, the number of cells to be infused, and the number of infusions required in order to attain this therapeutic range in hemi-betathal mice. Importantly, with prior minimal myelosuppression with 1 or 2 Gy, and using cell doses of 40 or 60 millions, 100% of the recipients were successfully engrafted at therapeutic levels, provided the cells were administered in two doses. This study has therefore determined the therapeutic chimeric level as 19-24% of normal cells, and has also defined the minimal transplantation modalities necessary for the stable and successful correction of the hemi-betathal phenotype.
Oxford advanced learner's English-Chinese dictionary = 牛津现代高级英汉双解词典 (1988)

This reference work has been revised and updated to contain simplified Chinese characters. It is designed specifically for Chinese students studying English in secondary schools up to university level and for adult learners of English who need a practical and informative dictionary.
Evaluation of Secure OpenID-Based RAAA User Authentication Protocol for Preventing Specific Web Attacks in Web Apps (2020)

Identity management (IdM) plays a significant role in managing user identities (IDs). However, IdM is challenging to handle the rapidly rising numerous kinds of Web-based applications nowadays. The OpenID 2.0 communication protocol is an improved solution for managing a user's IDs based on the OpenID URL identity. OpenID URL identity is not very much secure in specific Web-based attacks; for instance, session hijacking and phishing attacks often occur. The earlier OpenID-based methods secure OpenID URL identity with single, double, and triple authentication schemes. But Identity Provider (IdP) side is still not secure in Web attacks: if an attacker steals the IdP-side legal user information, then existing OpenID-based security techniques are unreliable. The anticipated OpenID Reverse Authentication Authorizing and Accounting (RAAA) user authentication-based protocol secured OpenID URL identity by providing two beneficial fields Secret Alphanumeric String (SAS) and Special Innovative PIN (SIP) that utilize in testing website both sides in reverse and cost-effective way. In this experiment, IdP and Relying Party (RP), both sides are being used secretly. Therefore, experimental websites also test to check the proposed triple authentication protocol. In this paper, we have compared our RAAA user authentication protocol with already available SSO protocol methods. The tested websites and comparative results represent that the anticipated design protocol is very much secure and reliable solution. The advanced cryptographic Single-Sign-On (SSO) secure protocol reduces the higher-level session hijacking and phishing attacks risk in an OpenID-based environment. We suggest future SSO protocol methods will be needed more in terms of the authorized user's identity authentication in Web-based applications.
Schiff base‐mediated co‐stimulation primes the T‐cell‐receptor‐dependent calcium signalling pathway in CD4 T cells (2001)

In addition to macromolecular interactions that provide co-stimulation during antigen-presenting cell (APC) and CD4+ T-cell conjugation, covalent chemical events between specialized ligands have been implicated in T-cell co-stimulation. These take the form of transient Schiff base formation between carbonyls and amines expressed on APC and T-cell surfaces. Small Schiff base-forming molecules, such as tucaresol, can substitute for the physiological donor of carbonyl groups and provide co-stimulation to T cells, thereby functioning as orally active immunopotentiatory drugs. The Schiff base co-stimulatory pathway in T cells has been partially characterized in terms of changes in Na+ and K+ transport, and activation of the mitogen activated protein kinase (MAPK) ERK2. In the present study, the effects of Schiff base co-stimulation by tucaresol on the T-cell receptor (TCR)-dependent pathway leading to Ca2+ release were investigated. Schiff base co-stimulation by tucaresol was found to prime for enhanced TCR-dependent phospholipase C-gamma phosphorylation, inositol 1,4,5-triphosphate production, and Ca2+ mobilization that correlated with functional enhancement of interleukin-2 production in primary T cells. The effects on Ca2+ occurred comparably in Jurkat and primary CD4+ T cells responding to anti-CD3 monoclonal antibody. Enhancement of the Ca2+ response required a 10-min priming period and was prevented by prior covalent ligation of cell-surface free amino groups by sulpho-N-hydroxy succinimido-biotin; clofilium-mediated inhibition of tucaresol-induced changes in intracellular K+; and selective inhibition of the MAPK pathway. The data are consistent with a priming mechanism in which late co-stimulation-triggered events exert a positive influence on early TCR-triggered events. In additional studies of murine T cells expressing trans-gene TCRs, tucaresol was likewise shown to prime for enhanced Ca2+ mobilization in response to physiological TCR-engagement by MHC-peptide complexes.
Maximum-Likelihood Estimation for Mixture Multivariate Stochastic Observations of Markov Chains (1985)

In this paper we discuss parameter estimation by means of the reestimation algorithm for a class of multivariate mixture density functions of Markov chains. The scope of the original reestimation algorithm is expanded and the previous assumptions of log concavity or ellipsoidal symmetry are obviated, thereby enhancing the modeling capability of the technique. Reestimation formulas in terms of the well-known forward-backward inductive procedure are also derived.
The Freedom to Choose: Transforming Content On-demand in the BSCW Shared Workspace System. (1997)

S.40-46
Subpixel image registration by estimating the polyphase decomposition of cross power spectrum (1996)

A method of registering images at subpixel accuracy has been proposed, which does not resort to interpolation. The method is based on the phase correlation method and is remarkably robust to correlated noise and uniform variations of luminance. We have shown that the cross power spectrum of two images, containing subpixel shifts, is a polyphase decomposition of a Dirac delta function. By estimating the sum of polyphase components one can then determine sub-pixel shifts along each axis.
SNA Management Services architecture for APPN networks (1992)

The introduction of Advanced Peer-to-Peer Networking (APPN) provides for a more flexible Systems Network Architecture (SNA) environment: end-user systems (physical units, or PUs) at the edge of a routing network no longer need a predefined relationship with a system services control point (SSCP) for network control purposes. This new flexibility creates challenges for SNA Management Services, however, since the SSCP-PU relationship provided a vehicle for network management as well as network control. To meet the needs of this peer-to-peer environment, the SNA Management Services architecture was extended to provide a management infrastructure that replaces the previous SSCP-PU relationship, and at the same time provides for much greater flexibility. This new infrastructure consists of a formalization of the focal-point/entry-point concept in the architecture and a transport technique for management services data that utilizes the facilities of Advanced Program-to-Program Communications (APPC) rather than the SSCP-PU session. Together this provides for a management structure in a peer network.
Lanthanide shift reagents for nuclear magnetic resonance spectroscopy (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLanthanide shift reagents for nuclear magnetic resonance spectroscopyAnthony F. Cockerill, Geoffrey L. O. Davies, Raymond C. Harden, and David M. RackhamCite this: Chem. Rev. 1973, 73, 6, 553–588Publication Date (Print):December 1, 1973Publication History Published online1 May 2002Published inissue 1 December 1973https://pubs.acs.org/doi/10.1021/cr60286a001https://doi.org/10.1021/cr60286a001research-articleACS PublicationsRequest reuse permissionsArticle Views1720Altmetric-Citations415LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aryl-2-halogenoalkylamines. Part XV. Some cationic and basically substituted aryl compounds (1955)

F. Bergel, J. L. Everett, J. J. Roberts and W. C. J. Ross, J. Chem. Soc., 1955, 3835 DOI: 10.1039/JR9550003835
Use of nitrogen and hydrogen in inductively coupled plasma mass spectrometry (1992)

Small amounts of N2 or H2 were added at the main gas inlet to the Ar forming the plasma of an inductively coupled plasma mass spectrometer. Experiments involving either Ar–N2 or Ar–H2 plasmas were carried out using an r.f. coil with an outside diameter of 31 mm while the sampling depth (9.0 mm), torch to sampler cone distance (1.5 mm) and r.f. power (1000 W) were kept constant. Signal intensities for a wide range of elements were enhanced while Ba2+, Ce2+, BaO+, CeO+, MoO+, TiO+, WO+ and ZrO+ were maintained below 3% of their singly charged ions (M+). Signal enhancement was greater with the Ar–N2 than the Ar–H2 plasma. Whereas the use of an Ar–N2 plasma was affected by interferences from polyatomic species of nitrogen, no significant increase in background signals was observed when the Ar–H2 plasma was used. In general, the signal-to-background ratio was increased for a wide range of elements investigated when either the Ar–N2 or Ar–H2 plasma was employed.