gebhart/patrepeval huggingface dataset:
Importance of Microparticles in Microcirculation and Diseases (2009)

Although generation of microparticles from stimulated cells is a universal event of the cell life, little is known about the mechanisms regulating this process. Only in the last ten years, microparticles are considered as vectors of biological information between cells. Levels of circulating microparticles are enhanced in a large number of cardiovascular pathologies including changes in the microcirculation associated with insulino-resistance and this has been associated with deleterious effects on cells from vascular wall, mainly, endothelial cells. However, under several conditions, microparticles released from different vascular cells can induce beneficial effects, such as repair of injured tissue favoring angiogenesis, release of nitric oxide from injured endothelium, for instance. This review emphasizes the increasing significance of microparticles in major cardiovascular pathological situations, as well as, the recent progress in the identification of other biological functions for microparticles, mainly, considering microparticles as potential therapeutic tools.
Annelation of enamines with 1-fluorovinyl methyl ketone (1975)

On condensation of enamines with 1-fluorovinyl methyl ketone, obtained by condensation of dichloro-fluoromethane with 2-methoxypropene, fluorinating annelation takes place giving 6-fluorocyclohexenones.
One year of SSL internet measurement (2012)

Over the years, SSL/TLS has become an essential part of internet security. As such, it should offer robust and state-of-the-art security, in particular for HTTPS, its first application. Theoretically, the protocol allows for a trade-off between secure algorithms and decent performance. Yet in practice, servers do not always support the latest version of the protocol, nor do they all enforce strong cryptographic algorithms.
A Vitamin D<sub>3</sub>Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21<sup>Waf1</sup>, and p27<sup>Kip1</sup><sup>1</sup> (2000)

Previous studies by our laboratory have shown that a noncalcemic fluorinated analog of 1alpha,25-dihydroxyvitamin D3, 1alpha,25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholcal ciferol (F6-D3), significantly reduced the frequency of colonic adenomas and completely abolished the development of colonic adenocarcinomas in rats treated with azoxymethane. The mechanisms involved in this analog's chemopreventive actions, however, remain unclear. In the present study, we now show that although both 1alpha,25-dihydroxyvitamin D3 and F6-D3 inhibited the proliferation of CaCo-2 cells, a human colonic adenocarcinoma cell line, by increasing their doubling times, only F6-D3 caused an arrest of these cells in the G1 phase of their cell cycle. This arrest was accompanied by an increase in the expression of the cyclin-dependent kinase (cdk) inhibitor proteins, p2Waf1 and p27Kip1, which served to decrease the activity of cyclin-dependent kinase 2 and cyclin-dependent kinase 6, whereas the expression and phosphorylation of pRB were unchanged. In contrast to the increased expression of these cdk inhibitors, the expression of cyclin E was decreased, which further inhibited the activity of cyclin-dependent kinase 2. Collectively, the inhibition of these cyclin-dependent kinases served to arrest the CaCo-2 cells, independent of changes in pRB. Furthermore, antibody neutralization studies suggest that transforming growth factor-beta may mediate the coassociations between cdk2 and p27Kip1 and cyclin E induced by F6-D3. These data indicate that cell cycle arrest may, at least in part, underlie the chemopreventive actions of F6-D3 observed in the azoxymethane model of colon cancer. Furthermore, if the antiproliferative action observed in CaCo-2 cells also occurs in human colonic epithelium, F6-D3 may have chemopreventive potential against human colon cancer, as well.
Self-assembled tunable photonic hyper-crystals (2013)

We demonstrate a novel artificial optical material, a photonic hyper-crystal, which combines the most interesting features of hyperbolic metamaterials and photonic crystals. Similar to hyperbolic metamaterials, photonic hyper-crystals exhibit broadband divergence in their photonic density of states due to the lack of usual diffraction limit on the photon wave vector. On the other hand, similar to photonic crystals, hyperbolic dispersion law of extraordinary photons is modulated by forbidden gaps near the boundaries of photonic Brillouin zones. Three dimensional self-assembly of photonic hyper-crystals has been achieved by application of external magnetic field to a cobalt nanoparticle-based ferrofluid. Unique spectral properties of photonic hyper-crystals lead to extreme sensitivity of the material to monolayer coatings of cobalt nanoparticles, which should find numerous applications in biological and chemical sensing.
Structure of an unexpected indole photolysis product (1986)

Etude du solvate acetate d'ethyle du tetrahydro-8,9,15,16 5bH, 14bH-tetraaza-5,7a,14,14c benzo [1,2-a:1',2'-c] difluorenecarboxylate-6 de methyle, C 26 H 24 N 4 O 2 •C 4 H 8 O 2 ; affinement jusqu'a R=0,052
Über die Chlorierung des Dimethylsulfids (1948)

Abstract Bei der Chlorierung von Dimethyl‐, symm . Dichlordimethyl‐ und Tetrachlordimethylsulfid wurden Chloroform, Thiophosgen, Penta‐ und Hexachlordimethylsulfid aufgefunden. Für das Tetrachlordimethylsulfid wurden physikalisch‐chemische Konstanten festgelegt. Als Hydrolyseprodukt konnte Trithioformaldehyd nachgewiesen werden. Bei der Chlorierung von Perchlormethylmercaptan in der Kälte im UV‐Licht wurden Tetrachlorkohlenstoff u. Schwefeldichlorid, beim Zerfall im UV‐Licht Thiophosgen, Tetrachlorkohlenstoff und Schwefelmonochlorid gefunden. Das nur bedingt stabile Penta‐ und Hexachlordimethylsulfid konnten angereichert und durch ihre Zerfallsprodukte nachgewiesen, aber aus einem Gemisch mit Perchlormethylmercaptan und Tetrachlorkohlenstoff nicht rein isoliert werden.
Écologie des bactéries fixatrices d'azote associées à la rhizosphère des céréales : mieux décrire pour mieux comprendre (1994)

National audience
Discharge Patterns of Hypoglossal Motoneurons During Fictive Breathing, Coughing, and Swallowing (2002)

We performed a series of experiments to study the intracellular activity of 58 hypoglossal motoneurons (HMs) in decerebrate, paralyzed, and ventilated cats. Changes in membrane potentials (MP) and discharge activities were evaluated during fictive breathing (FB), swallowing (FS), and coughing (FC). FS and FC were elicited by electrical stimulation of the superior laryngeal nerves. FB, FS, and FC all exhibited characteristic discharge patterns of the phrenic, abdominal, pharyngeal branch of the vagus, and hypoglossal nerves. Thirty-nine HMs displayed respiratory modulation, and 19 were nonrespiratory modulated. Nine HMs did not exhibit MP changes during FB, FS, and FC. During FS, 49 HMs exhibited MP changes consisting of depolarization, hyperpolarization or hyperpolarization-depolarization. HMs involved in FS were either respiratory modulated (n = 38) or not (n = 11). Only 20 HMs displayed MP changes and/or discharge activity during FC. All but two HMs fired during the expiratory phase of FC or at the end of this reflex. All HMs involved in FC (n = 20) were also modulated during both FB and FS. Our results suggest that the XII nucleus is functionally divided into common and distinct subsets of HMs based on their spontaneous activities and responses observed during FS and FC. The changes in MP and discharge frequencies observed during the three behaviors also suggest that HMs are driven by specific premotor neurons during FS, whereas a common premotor pathway is involved during FB and FC.
Function of Lysine-148 in dTDP-D-Glucose 4,6-Dehydratase from Streptomyces antibioticus Tu99 (2002)

dTDP-D-glucose 4,6-dehydratase (TDPDH) catalyzes the conversion of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose, and requires NAD + as a coenzyme for its catalytic activity. The dTDP-D-glucose 4,6-dehydratase from Streptomyces antibioticus Tu99 tightly binds NAD + [19]. In order to determine the role of lysine-148 in the NAD + binding, the lysine of the dTDP-D-glucose 4,6-dehydratase from Streptomyces antibioticus Tu99 was mutated to various amino acids by site-directed mutagenesis. The catalytic activity of the four mutated enzymes of TDPDH did not recover after addition of NAD + . However, the activity of K159A, the mutated enzyme of UDP-D-glucose 4-epimerase (UDPE), recovered after the addition of NAD + [15]. Although dTDP-glucose 4,6-dehydratase, and UDP-galactose (glucose) 4-epimerase are members of the short-chain dehydrogenase/reductase SDR family and the lysine-148 of TDPDH was highly conserved as in UDPE (Lys-159), the function of the lysine-148 of TDPDH was different from that of UDPE. The mutated enzymes showed that the lysine-148 of the dTDP-D-glucose 4,6-dehydratase played no role in the NAD + binding. Accordingly, it is suggested that the lysine-148 of the dTDP-D-glucose 4,6-dehydratase is involved in the folding of TDPDH.
Fingerprint sensor technology - sensor structure/chip, sensing scheme, and system (2005)

This paper describes sensor structure, circuit and system techniques for a capacitive fingerprint sensor LSI and a user authentication system. The LSI must be reliable, sensitive, and tolerant to changes in the sensor surface conditions for capturing clear fingerprint image over long-term use. The LSI features a sensor structure, sensing circuit, calibration circuit and adjustable A/D convener. The system has to provide the controllability of captured fingerprint images to be suitable for identification under various conditions. The system features an adaptive fingerprint-sensing scheme. The fingerprint sensor LSI was fabricated using the 0.5-/spl mu/m CMOS process/sensor process and the fingerprint identification system was developed with the above techniques. The sufficient performance was achieved for a practical user authentication system and the effectiveness of the fingerprint sensor technology was confirmed.
Advanced subtraction angiography: mask selection and image registration (2002)

Conventional DSA in cardioangiography is hampered by the rapid and irregular heart movement. Thus, extended subtraction artefacts occur due to the bad congruence of corresponding structures. A native sequence of one heart cycle serves as a pool of mask images. The ECG signal is used to find the corresponding mask image. An image registration algorithm was developed to estimate displacements in numerous (>6000) local image regions. The resulting motion pattern is used to compute a new warped image with maximum congruence. This calculated image becomes the new mask in the subsequent subtraction. The algorithm works fully automatically and does not need any interaction like the demarcation of landmarks. Better assessment of the coronary vessels and the ventricle with reduced artefacts is the diagnostic benefit of this image enhancement.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Programmable optical perfect shuffle interconnection network using fredkin gates (1992)

Abstract An efficient optical implementation of perfect shuffle interconnection network using Fredkin gates is presented. The proposed architecture is programmable, uses very few switching elements, and is suitable for digital/optical multiprocessor systems. © 1992 John Wiley & Sons, Inc.
The Role of Colony Stimulating Activity in Modulating Murine Diffusion Chamber Granulopoiesis (1980)

We studied the effects of high circulating Colony Stimulating Activity (CSA) levels and irradiation induced marrow hypoplasia in CF1 and C57B1/6J host mice upon granulopoiesis in intraperitoneal diffusion chamber (DC) cultures. Serial endotoxin injections resulted in marked elevation of circulating CSA for the first half of an 8 d culture period, and CSA was shown to diffuse into the chamber environment; yet this manipulation alone did not significantly accelerate DC cell growth. Pre-irradiation of the host mice produced no elevation of circulating CSA during the early phase of culture, but resulted in significant stimulation of DC granolopoiesis. Fluctuations in circulating inhibitors of in vitro granulopoiesis did not correlate well with DC cellularity. We conclude that endogenous CSA elevation does not providean effective stimulus per se for granulocyte-monocyte proliferation within DC culture and cannot be solely responsible for mediating the exuberant DC granulopoietic response seen in the pre-irradiated host.
Heat sources and the emitting surfaces (1995)

Thermophotovoltaics utilizing broadband and selective emitters require of various materials for a wide range of temperatures and environments. Currently, materials are available that will operate successfully in both vacuum and oxidizing ambients at temperatures of up to 1500 C. The use of silicon carbide (SiC) of various dimensions in applications such as heat exchangers and molten metal transfer lends credence to the expectation that it can be adapted for use as the emitter of the TPV system. New materials, composites, emissive coatings and control of micro‐structure can be used to achieve improved radiant efficiency. (AIP)
Characterization of Dust and Debris Collected from the Nova Facility (2001)

Dust and debris were collected from the Nova laser facility in April 1999 to provide evidence of particulate generation and transport mechanisms relevant to fusion power safety analyses. Samples were obtained at specified locations within the Nova chamber with a vacuum filter system, cascade impactors, and metallurgical replicating tape (acetate tape). Average surface mass density of material collected from locations with measured surface area ranges from 3.13 μg/cm2 on the mid-plane vertical surface to 3250 μg/cm2 on the vessel bottom. Estimated total dust inventory is 44 grams. Specific surface area of dust collected from several locations is nearly uniform with an average value of 0.435 m2/g. Particle size distributions of the collected material show a range of count median diameters (CMD) between 0.67 and 1.19 μm with geometric standard deviations (GSD) between 1.63 and 2.76. Mass median diameters for dust collected with the two cascade impactors are 5.26 μm and 8.85 μm. The shape of the volumetric size distribution indicates dust particles of various shapes. Composition analysis performed by energy dispersive X-ray analysis indicated the presence of O, Al, Cu, along with trace quantities of Fe, Au, and Be. Atomic emission ICP analysis also indicated the presence of Si, O, and Cu in dust samples.
[A Dumbbell-Type Thoracic Spinal Lipoma: A Case Report]. (2016)

Spinal lipomas are rare, accounting for less than 1% of all spinal tumors. Most are associated with spinal dysraphism. Spinal lipomas without spinal dysraphism are uncommon;they are typically subpial tumors. Some tumors are located both inside and outside the dura mater (so-called "dumbbell-type"). Herein, we report a patient with a dumbbell-type thoracic spinal lipoma. A man in his 50's complained of progressive gait disturbance, dysesthesia in his left leg, and hyperesthesia in his right leg. His symptoms were worsened by exercise. CT and MRI revealed a thoracic spinal lipoma extending from the spinal cord to the intervertebral foramen at the Th 6-8 level. He underwent partial tumor removal and untethering. Postoperatively he reported gradual symptom abatement. Dumbbell-type spinal lipomas are very rare. Besides partial removal of the tumor, untethering should be considered when symptoms are associated with tethering of the spinal cord.
New Efficient Access to Thieno[3,2‐b]pyridine Derivatives via Regioselective Lithiation of 3‐Methylthiopyridine. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Channel-Adaptive Beamforming Method for OFDMA Systems in frequency-Selective Channels (2005)

In this paper, a channel-adaptive beamforming method is proposed for OFDMA (Orthogonal Frequency Division Multilexing Access) systems with smart antenna, in which the size of a cluster is determined adaptively depending on the frequency selectivity of the channel. The proposed method consists of 4 steps: initial channel estimation, refinement of channel estimates, region-splitting, and computation of weight vector for each region. In the proposed method, the size of a cluster for resource unit is determined adaptively according to a region-splitting criterion. It is shown by simulation that the proposed method shows good performances in both frequency-flat and frequency-selective channels.
Two-Step Red-Mediated Recombination for versatile High-Efficiency Markerless DNA Manipulation in <i>Escherichia Coli</i> (2006)

Red recombination using PCR-amplified selectable markers is a well-established technique for mutagenesis of large DNA molecules in Escherichia coli. The system has limited efficacy and versatility, however, for markerless modifications including point mutations, deletions, and particularly insertions of longer sequences. Here we describe a procedure that combines Red recombination and cleavage with the homing endonuclease I-SceI to allow highly efficient, PCR-based DNA engineering without retention of unwanted foreign sequences. We applied the method to modification of bacterial artificial chromosome (BAC) constructs harboring an infectious herpesvirus clone to demonstrate the potential of the mutagenesis technique, which was used for the insertion of long sequences such as coding regions or promoters, introduction of point mutations, scarless deletions, and insertion of short sequences such as an epitope tag. The system proved to be highly reliable and efficient and can be adapted for a variety of different modifications of BAC clones, which are fundamental tools for applications as diverse as the generation of transgenic animals and the construction of gene therapy or vaccine vectors.
Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells (1992)

Bone marrow (BM) stromal cells, which include macrophages, fibroblasts, endothelial cells, and adipocytes, have been shown to produce several factors that modulate the growth of BM progenitors. Hepatocyte growth factor (HGF) is a fibroblast-derived factor and has recently been shown to be a ligand for the c-met proto-oncogene, a member of the receptor class of tyrosine kinases. c-met messenger RNA (mRNA) is predominantly expressed in epithelial cells, but has been detected in several murine hematopoietic progenitor cell lines, suggesting that HGF and met might function during hematopoiesis. Here, BM cells were found to express both met mRNA and protein. Moreover, HGF was shown to synergize with interleukin-3 and granulocyte-macrophage colony-stimulating factor to stimulate colony formation of hematopoietic progenitor cells in vitro. These results show that, in addition to its activity on epithelial cells, HGF is a new member of the functionally related group of factors that modulate hematopoiesis.
Homogeneous coding for genetic algorithm based parameter optimization (2002)

A new chromosome encoding method named homogeneous coding is proposed for genetic algorithm based optimization of numerical parameters. Homogeneous coding generates a bit string code in which each bit contributes equally to the value represented by the code. Homogeneous coding and its generation method are introduced, and five basic characteristic are proposed to compare and analyze chromosome encoding methods. By using these five characteristics, homogeneous coding is compared with conventional coding methods such as binary coding and gray coding. It is proved experimentally that diversity of the gene pool is maintained in homogeneous coding better than in conventional methods and homogeneous coding is effective for optimization of numerical parameters whose searching space is complicated.
Molecular Determinants for the Selective Inhibition of Cyclooxygenase-2 by Lumiracoxib (2007)

Lumiracoxib is the first example of a marketed COX-2 inhibitor of the arylacetic acid class, and it is reported to be the most selective COXIB in vivo. However, the molecular basis of its COX-2 inhibition has not been completely defined. Using standard assays, lumiracoxib was found to be a poor inhibitor of purified ovine COX-1 and a relatively weak inhibitor of purified human COX-2. The extent of COX-2 inhibition plateaued at around 50% and suggested that the inhibitor may be reversibly bound to the enzyme. Kinetic studies with lumiracoxib demonstrated that it was a time-dependent and slowly reversible inhibitor of human COX-2 that exhibited at least two binding steps during inhibition. Derivatives of lumiracoxib were synthesized with or without the methyl group on the phenylacetic acid ring and with various substitutions on the lower aniline ring. Inhibition studies demonstrated that the methyl group on the phenylacetic acid ring is required for COX-2 selectivity. The chemical identity and position of the substituents on the lower aniline ring were important in determining the potency and extent of COX inhibition as well as COX-2 selectivity. Mutation of Ser-530 to Ala or Val-349 to Ala or Leu abolished the potent inhibition observed with wild-type human COX-2 and key lumiracoxib analogs. Interestingly, a Val-349 to Ile mutant was inhibited with equal potency to human COX-2 with 2,6-dichloro-, 2,6-dimethyl-, or 2-chloro-6-methyl-substituted inhibitors and, in the case of lumiracoxib, actually showed an increase in potency. Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition.
Normal values and physiological data (2010)

Abstract Paediatric Intensive Care gives practical and realistic advice for children's doctors and nurses in intensive care.
New telechelic polymers and sequential copolymers by polyfunctional initiator‐transfer agents (inifers) LVII. Chlorine telechelic poly(<i>p</i>‐chlorostyrene) (1991)

Abstract The polymerization of p ‐chlorostyrene (pClSt) under carbocationic conditions has been investigated. The use of binifers 1,4‐di(2‐chloro‐2‐propyl) benzene (pDCC) and 1,3‐di(2‐chloro‐2‐propyl)‐5‐ tert ‐butylbenzene (m‐ t BuDCC) in conjunction with BCl 3 coinitiator in CH 3 Cl diluent at −60 and −35°C give α,ω‐di‐benzylic chlorine‐capped polymer s ClPpClStCl s . According to kinetic investigations the inifer mechanism is operative and both binifers are efficient in controlling the end structures, molecular weights, and to a certain extent molecular weight distributions (MWD). Strong circumstantial evidences have been generated to demonstrate the satisfactory synthesis of s ClPpClStCl s and the absence of indanyl end‐groups, i.e., structural considerations, linearity of inifer plots, quantitative Cl end‐group microanalysis, FTIR spectroscopy, and blocking experiments. The latter involved the blocking of THF from the sec ‐benzylic chlorine end‐groups by AgPF 6 and thus led to the synthesis of a new triblock copolymer PTHF‐b‐PpClSt‐b‐PTHF. Interestingly, the isotactic content (mm triads and mmmm pentads) of PpClSt is significantly higher than that of polymer prepared by free‐radical induced polymerization. The T g of a PpClSt of M̄ n = 5700 g/mol was 123°C.