gebhart/patrepeval huggingface dataset:
ChemInform Abstract: An Improved Optical Resolution of 3‐Acetylthio‐2‐methylpropionic Acid by Use of a New Chiral Amine, N‐Isopropyl(phenylalaninol). (1990)

ChemInformVolume 21, Issue 1 Preparative Organic Chemistry ChemInform Abstract: An Improved Optical Resolution of 3-Acetylthio-2-methylpropionic Acid by Use of a New Chiral Amine, N-Isopropyl(phenylalaninol). T. SAWAYAMA, T. SAWAYAMA Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorM. TSUKAMOTO, M. TSUKAMOTO Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorT. SASAGAWA, T. SASAGAWA Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorS. NARUTO, S. NARUTO Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorJ. MATSUMOTO, J. MATSUMOTO Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorH. UNO, H. UNO Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this author T. SAWAYAMA, T. SAWAYAMA Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorM. TSUKAMOTO, M. TSUKAMOTO Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorT. SASAGAWA, T. SASAGAWA Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorS. NARUTO, S. NARUTO Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorJ. MATSUMOTO, J. MATSUMOTO Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this authorH. UNO, H. UNO Explor. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, JapanSearch for more papers by this author First published: January 2, 1990 https://doi.org/10.1002/chin.199001114AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume21, Issue1January 2, 1990 RelatedInformation
ChemInform Abstract: SYNTHESIS OF 4,6‐DIAMINO SUGARS (1982)

Abstract Ausgehend vom Diacetoxydidesoxypyranosid (I) wird nach Verseifung und Überführung in das Bis‐tosylat (III) mit NaN 3 ein Gemisch der Mono‐′ und Bis‐azidozucker (IV)‐(VII) erhalten.
Significance of FAB subclassification of “acute myeloid leukemia, NOS” in the 2008 WHO classification: analysis of 5848 newly diagnosed patients (2013)

The World Health Organization (WHO) classifies acute myeloid leukemia (AML) via genetic, immunophenotypic, biological, and clinical features. Still, "AML, not otherwise specified (NOS)" is further subdivided based on morphologic criteria similar to those of the French-American-British (FAB) classification. We analyzed the relevance of this practice in patients with newly diagnosed "AML, NOS" with available FAB information undergoing curative-intent therapy in trials of 3 cooperative study groups (Dutch-Belgian Cooperative Trial Group for Hematology/Oncology [HOVON], UK Medical Research Council/National Cancer Research Institute [MRC/NCRI], and the US cooperative group Southwest Oncology Group [SWOG]) or at MD Anderson Cancer Center. Ignoring information on NPM1 and CEBPA, 5848 patients met criteria for "AML, NOS." After multivariate adjustment, FAB M0 was independently associated with significantly lower likelihood of achieving complete remission and inferior relapse-free and overall survival as compared with FAB M1, M2, M4, M5, and M6, with inconclusive data regarding M7. However, restricting attention to known NPM1(neg) patients, FAB M0 was no longer associated with worse outcomes; restricting attention to patients known to be NPM1(neg)/CEPBA(neg) (ie, honoring the provisional entities of "AML with mutated NPM1" and "AML with mutated CEBPA") did not affect this result. In conclusion, in the 2008 WHO classification scheme, FAB subclassification does not provide prognostic information for "AML, NOS" cases if data on NPM1 and CEBPA mutations are available.
Development of the integrated environmental control model. Quarterly progress report, April 1995--June 1995 (1995)

The purpose of this contract is to develop and refine the Integrated Environmental Control Model (IECM). In its current configuration, the IECM provides a capability to model various conventional and advanced processes for controlling air pollutant emissions from coal-fired power plants before, during, or after combustion. The principal purpose of the model is to calculate the performance, emissions, and cost of power plant configurations employing alternative environmental control methods. The model consists of various control technology modules, which may be integrated into a complete utility plant in any desired combination. In contrast to conventional deterministic models, the IECM offers the unique capability to assign probabilistic values to all model input parameters, and to obtain probabilistic outputs in the form of cumulative distribution functions indicating the likelihood of different costs and performance results. The work in this contract is divided into two phases. Phase I deals with further developing the existing version of the IECM and training PETC personnel on the effective use of the model. Phase H deals with creating new technology modules, linking the IECM with PETC databases, and training PETC personnel on the effective use of the updated model. The present report summarizes recent progress on the Phase I effort during the period April 1, 1995 through June 30, 1995. This report presents additional revisions to the new cost models of flue gas desulfurization (FGD) technology initially reported in our fourth quarterly report. For convenience, the complete description of the revised FGD models are presented here.
Resting State Networks in 22q11 Deletion Syndrome: Neuro-Functional Implications (2011)

Reference EPFL-CONF-171425View record in Web of Science Record created on 2011-12-16, modified on 2017-05-10
Critical Operating Conditions For A Novel Flying Tester (1993)

Increased recording densities are often achieved through a reduction in the flying height over a thin film disk possessing diminishing surface roughness. Flying heights will continue to decrease until the head-disk interface (HDI) operates under quasi-contact conditions, i.e., ultra-low flying with intermittent slider-disk collisions. The failure mechanisms that occur in such quasi-contact devices may differ from those experienced in current, higher flying hard drive assemblies. In this paper, the authors will present the experimental, numerical, and theoretical tools that have been developed to study the behavior of the HDI under ultra-low flying conditions. These tools include an accelerated flyability tester and a numerical algorithm applicable to highly rarefied air bearings that possess large pressure gradients. Air bearing simulation results, as well as the results from a simple flying height scaling analysis, will be compared to flying test results in both air and helium to obtain insight into the stability of the HDI under accelerated testing conditions. A new concept introduced in this paper is that of critical conditions, i.e., the band of operating conditions which mark the transition from stable to erratic behavior, which can be determined both experimentally and theoretically. Such insight should provide design criteria for both quasi-contact storage devices, as well as novel accelerated wear testers.
Development of Molecular Imprinted Polymer for Selective Adsorption of Benz[a]pyrene Among Airborne Polycyclic Aromatic Hydrocarbon Compounds (2011)

This study combined molecular imprinted polymers (MIPs) and solid-phase extraction (SPE) to create a novel sample pretreatment technique for chemical analysis of polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke. Experimental results demonstrated that MIPs have good selectivity for benz[a]pyrene (BaP) among mixtures of 16 PAH solutions. Molecular imprinted SPE (MISPE) cartridges were applied to a sample taken from mainstream smoke from a cigarette. Based on functional monomer and crosslinker, this study investigated four groups of MIPs. After each template was removed, tests on capacity, selectivity, recovery, scanning electron microscope observations, and real environmental sample tests were conducted. Experimental results showed that MIP-3 (methacrylic acid-co-trimethylolpropane trimethacrylate) is the best MIP, with a capacity of 7.80 ± 0.8 (μg/g), BaP selectivity exceeding 84%, and recovery exceeding 80%. In the environmental sample tests, that is, mainstream smoke from reference cigarettes 3R4F, 87% of BaP was adsorbed by the MISPE cartridge compared with that adsorbed by the filters. All experimental results suggested that MISPE can more effectively adsorb BaP among the 16 different PAHs in mixtures, reduce background interferences, and increase signal resolution as compared with traditional extraction techniques. Additionally, using MISPE cartridges in sample pretreatment reduced both the analysis time and the amount of organic solvent used. In addition, using MISPE may also extract toxic target analytes from a complex sample selectively and more effectively than traditional Soxhlet extraction. Combination of MIP-3 and SPE for environmental sample pretreatment offers a useful tool for selective isolation of the mutagenic PAHs. This study is also the first to apply an MISPE cartridge in the analysis of trace-level BaP in cigarette smoke.
Skating down a steeper slope: The effect of fear on geographical slant perception (2010)

Previous research in our lab has shown that conscious awareness of the slant of a hill is overestimated, but visually guided actions directed at the hill are relatively accurate (Proffitt et al., 1995). In addition, steep hills were consciously estimated to be steeper from the top as opposed to the bottom, apparently because these hills were too steep to walk down and were viewed as dangerous. Furthermore, when an observer's physiological potential was manipulated by having him go on a long run or wear a heavy backpack, hills appeared even steeper with the conscious measures of slant, but the visually guided action was unaffected (Bhalla & Proffitt, 1999). In the present studies, we extend this research to show that viewing the hill in a fearful way also increases conscious estimates of slant, but not visually guided actions. Participants were situated at the top of a hill and stood either on a skateboard or on a wooden box of the same height. They gave three estimates of the slant of the hill: verbal report of the angle of the hill in degrees, a visually matched estimate of the slant, and a visually guided action (a haptic palmboard). After participants gave the three estimates of slant, their fear of descending the hill was assessed with a continuous rating scale. Experience on skateboards was also assessed, however almost no participants had substantial experience with skateboarding. Those participants that stood on the skateboard and reported feeling scared verbally judged the hill to be steeper and overestimated with the visual matching measure relative to those participants who stood on the box. However, the visually guided action measure was accurate across conditions. These results suggest that our explicit awareness of slant is influenced by the fear associated with a potentially dangerous action. As was found in our previous work, the visually guided action was unaffected by this experimental manipulation.
Efficacy of continuous flucytosine infusion against Candida lusitaniae in experimental hematogenous murine candidiasis (1996)

Candida lusitaniae may cause life-threatening infections in the immunocompromised host and may be resistant to amphotericin B. Flucytosine (5-FC) is very active against C. lusitaniae isolates in vitro, while the in vivo response of murine infection to 5-FC is not as good. To evaluate the hypothesis that this discrepancy may be primarily due to the short half-life of 5-FC in mice, we compared the same total dosage of 75 mg of 5-FC per kg of body weight per day given by bolus injections or infused continuously via a subcutaneously implanted pump in immunosuppressed CF1 mice infected with C. lusitaniae. The fungal titers in the kidneys of mice treated with the continuous 5-FC infusion were significantly lower (P < or = 0.05) than those in the kidneys of mice that received bolus injections once or thrice daily. The antifungal activity of 5-FC against murine candidiasis is best evaluated when the drug is administered by continuous infusion.
Cooperative nonradiative cross-relaxation in crystals of La(1−x)CexF3 solid solutions (2000)

The phenomenon of concentration quenching of the luminescence from donor ions in crystals of La1−x CexF3 solid solutions was studied. A cooperative nonradiative energy transfer from a single excited neodymium ion to a cooperative acceptor representing a couple of cerium ions, as well as from a single erbium ion to three cerium atoms (also forming a cooperative acceptor center), was observed.
Addition of aryl nitrenes to olefins (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of aryl nitrenes to olefinsRudolph A. Abramovitch, Stanley R. Challand, and Yorinobu YamadaCite this: J. Org. Chem. 1975, 40, 11, 1541–1547Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/jo00899a004https://doi.org/10.1021/jo00899a004research-articleACS PublicationsRequest reuse permissionsArticle Views729Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A New, Facile Synthesis of 1,4,7,10-Tetraazacyclododecane:  Cyclen (2002)

This report outlines a new and efficient synthesis of cyclen (1,4,7,10-tetraazacyclododecane, 1) utilizing bis-imidazoline, 6 (1,1'-ethylenedi-2-imidazoline), with 1,2-dibromoethane. General conditions were developed, allowing for the simple, three-step synthesis of 1 at the multigram scale with an isolated overall yield approaching 65%. The cyclization of 6 produced by the condensation of triethylene tetraamine (TETA) with N,N-dimethylformamide dimethyl acetal, gave the twelve-membered, imidazolinium, cyclized intermediate bromide salt, 7 (2,3,4,5,6,7,8,8c-octahydro-1H-4a,6a,8a-triaza-2a-azoniacyclopent[fg]acenaphthylene), which hydrolyzed to 1 with the use of hot, aqueous caustic. Hydrolysis of 7 under milder conditions formed the 1,4,7,10-tetraazabicyclo[8.2.1]tridecan-13-one (20). Mechanistically, the formation of 7 may be rationalized as involving a diaminocarbene that undergoes an intramolecular carbon-hydrogen insertion.
HIGH SEROPREVALENCE OF HTLV-1 AMONG CHILDREN AND PREGNANT WOMEN INHABITANTS OF THE HIGH LANDS FROM JUJUY. ARGENTINA. (1999)

P096 Introduction: The seroprevalence of HTLV-I infection among blood bank donors in Jujuy province has been estimated in 0.9%. These seropositivity was found to be higher among females and to increase with age. Objetive: In order to investigate the geographic distribution of HTLV-I seroprevalence among inhabitants groups from high lands of Jujuy a seroepidemiological survey was conducted. Method: A total of 1456 children aged between 18 months and 11 years and 335 pregnant women from La Puna, Quebrada, Valle and Ramal areas were included in the present study. Specimens were tested for the presence of HTLV-I/II antibodies by the PA technique. Positive samples were confirmed by the IFA assay. Results:(Table)TableConclusions: These places with higher prevalence are located over 2.500mosl, the majority are amerindians descendants, living in remote places where migration rate is low and inbreeding index is high. The finding of HTLV-I infection among children suggests transmission of the virus by prolonged breast feeding.
Tailoring the transmission of liquid-core waveguides for wavelength filtering on a chip (2007)

The combination of integrated optics and microfluidics in planar optofluidic devices carries the potential for novel compact and ultra-sensitive detection in liquid and gaseous media. Single molecule fluorescence detection sensitivity in planar beam geometry was recently demonstrated in liquid-core antiresonant reflecting optical waveguides (ARROWs) fabricated on a silicon chip. A key component of a fully integrated single-molecule sensor is the addition of an optical filtering capability to separate excitation beams from much weaker generated fluorescence or scattering signals. This capability will eventually allow for integration of the photodetector on the same chip as the optofluidic sensing part. It has been theoretically shown that the wavelength-dependent transmission of liquid-core ARROWs can be tailored to efficiently separate excitation and fluorescence. Here, we present the wavelength dependent transmission of air-core ARROW waveguides, using a highly nonlinear photonic crystal fiber to generate a broadband excitation spectrum, and the design of liquid-core ARROW waveguides with integrated filter function. The air-core waveguide loss shows pronounced wavelength dependence in good agreement with the design, demonstrating the potential of tailoring the optical properties of liquid-core waveguides to accommodate single-molecule sensing on a chip. We also present an ARROW design to produce wavelength-dependent transmission that is optimized for fluorescence resonance energy transfer (FRET) studies with high transmission at 573 nm and 668nm, and low transmission at 546 nm.
Competing interactions contributing to α‐helical stability in aqueous solution (1995)

The stability of a 15-residue peptide has been investigated using CD spectroscopy and molecular simulation techniques. The sequence of the peptide was designed to include key features that are known to stabilize alpha-helices, including ion pairs, helix dipole capping, peptide bond capping, and aromatic interactions. The degree of helicity has been determined experimentally by CD in three solvents (aqueous buffer, methanol, and trifluoroethanol) and at two temperatures. Simulations of the peptide in the aqueous system have been performed over 500 ps at the same two temperatures using a fully explicit solvent model. Consistent with the CD data, the degree of helicity is decreased at the higher temperature. Our analysis of the simulation results has focused on competition between different side-chain/side-chain and side-chain/main-chain interactions, which can, in principle, stabilize the helix. The unfolding in aqueous solution occurs at the amino terminus because the side-chain interactions are insufficient to stabilize both the helix dipole and the peptide hydrogen bonds. Loss of capping of the peptide backbone leads to water insertion within the first peptide hydrogen bond and hence unfolding. In contrast, the carboxy terminus of the alpha-helix is stable in both simulations because the C-terminal lysine residue stabilizes the helix dipole, but at the expense of an ion pair.
Tomography of red blood cells by multiple-wavelength digital holographic microscopy (2009)

We present a method enabling cell tomography by multiple-wavelength digital holographic microscopy. 20 reflection holograms between 485 and 670 nm are sequentially acquired, then the wavefronts are summed to obtain 3D tomographic reconstruction of red blood cells.
Retinoic acid effects on an SV‐40 large T antigen immortalized adult rat bone cell line (1999)

Clonal cell lines were established from adult rat tibia cells immortalized with SV-40 large T antigen. One clone (TRAB-11), in which retinoic acid (RA) induced alkaline phosphatase (AP) activity, was selected for further study. The TRAB-11 cells express high levels of type I collagen mRNA, type IV collagen, fibronectin, practically no type III collagen, little osteopontin, and no osteocalcin. RA stimulates proliferation of TRAB-11 cells (starting at 10 pM) and survival (starting at 100 pM). TRAB-11 cells synthesize fibroblast growth factor-2 (FGF-2), which has potent autocrine mitogenic effects on these cells and acts synergistically with RA. TRAB-11 cells attach better to type IV collagen than to fibronectin or laminin. Cell attachment to type IV collagen is increased by RA and decreased (65%) by an antibody directed against α1β1 integrin. RA up-regulates steady-state levels of α1 mRNA without affecting β1 mRNA expression. In conclusion, we report the establishment of a clonal cell line from the outgrowth of adult rat tibiae which is highly sensitive to RA in its growth and survival in culture, apparently as a result of integrin-mediated cell interaction with extracellular matrix proteins. J. Cell. Physiol. 179:267–275, 1999. © 1999 Wiley-Liss, Inc.
Critical Dimension Control of Poly-Butene-Sulfone Resist in Electron Beam Lithography (1994)

Critical dimension uniformity is one of the key parameters to define the performance of electron beam lithography as well as the other lithography technologies. The characteristics of poly-butene-sulfone (PBS), a positive-type electron resist, have been investigated from the view-point of critical dimension control, using two types of electron beam lithography systems which use Gaussian spot and variable-shaped beams. It has been elucidated that the sensitivity of the PBS has a strong relationship with humidity during development. When the humidity changes from 30% to 32%, the sensitivity increases corresponding to the increase of 1 µ C/cm 2 dosage. A very good critical dimension uniformity of less than 0.04 µ m has been attained using a variable-shaped beam at 30% humidity. The spot beam can also obtain a good pattern width uniformity at 32% humidity and 4.5 µ C/cm 2 dosage. It is expected to correct the proximity effect in PBS by selecting the electron dosage related to humidity.