gebhart/patrepeval huggingface dataset:
Are there geographic differences in the outcome of patients (pts) with metastatic renal cell carcinoma (mRCC) treated with sunitinib (su)? (2013)

458 Background: Geographic differences in the outcome of pts have been described in various cancers. The VEGFR inhibitor su is a standard treatment (tx) for mRCC. The effect of geographic differences on the outcome of su tx in mRCC is poorly defined. We aimed to study the effect of geographic differences on outcome of su tx in mRCC. Methods: We performed an international multicenter retrospective study of unselected cohort of 275 mRCC pts, who were treated with su from 2004 to 2012 in 7 centers across the United States and Middle East (ME; Israel). Clinicopathologic and prognostic factors, and tx outcome were compared between United States (n=133) and ME (n=142) pts. Chi-square and Fisher's exact tests were used to compare categorical variables, and two-sample t-test was used to compare continuous endpoints. Progression free survival (PFS) and overall survival (OS) were determined by Cox regression. Results: Median age was 61 (United States) vs. 65 (ME, p = 0.01). The groups were balanced regarding gender, Heng risk, past nephrectomy, RCC histology, presence of ≥ 2 metastatic sites, lung/liver/bone metastasis, use of angiotensin system inhibitors (ASI), prior cytokines/ targeted txt, su induced HTN, and su dose reduction/tx interruption secondary to side effects. The incidence of active smokers (28% vs. 15%, p =0.01), bisphosphonates users (23% vs. 13%, p = 0.03) and pts with pre-tx neutrophil to lymphocyte ratio (NLR) ≤ 3 (63% vs. 49%, p = 0.04) was higher among ME pts. In United States vs. ME pts, objective response was partial response/stable disease 77% (n=102) vs. 79% (n=112), and progressive disease at first imaging evaluation within the first 3 months (mos) 23% (n=31) vs. 21% (n=30) (p = 0.77, OR 1.1). Median PFS was 8 vs. 12 mos (HR=1.8, p < 0.0001), and median OS 21 vs. 22 mos (HR=0.94, p = 0.9) in United States vs ME pts. Factors associated with PFS in multivariate analysis of the entire cohort (n=275) were geographic location (United States vs. ME), Heng risk, RCC histology, su induced HTN, ASI use, pre-tx NLR, and smoking status. Conclusions: Geographic differences in clinicopathologic factors and PFS of pts with mRCC treated with su may exist. This should be further investigated, and if validated, applied in clinical practice and clinical trials.
Cyclic Nucleotides and Somatomedin Action in Cartilage* (1982)

The role of cyclic nucleotides was evaluated in the stimulation of cartilage metabolism by somatomedin-C (Sm-C). The effects of cAMP and cyclic guanosine monophosphate (cGMP) analogs on matrix synthesis were evaluated. The effects of Sm-C on tissue concentrations of these cyclic nucleotides were investigated. Likewise, the direct effects of Sm-C on the activities of cartilage adenylate cyclase, guanylate cyclase, and phosphodiesterase were determined. We found that tissue concentrations of cAMP in cartilage declined rapidly during organ culture, despite the presence of serum or Sm-C, cGMP concentrations in cartilage declined rapidly during control incubations but were augmented significantly at 30 and 60 min of incubation with the addition of serum or Sm-C. Thereafter, cGMP concentrations declined toward the levels of incubated control cartilages. Sm-C had no effect on phosphodiesterase activity. N6-Monobutyryl cAMP stimulated sulfate uptake, but dibutyryl cGMP did not. Sm-C did not stimulate adenylate cyclase in purified plasma membranes from chondrocytes, whereas it stimulated both plasma membrane and cytosol guanylate cyclase at concentrations of Sm-C as low as 10(-12) M. These data would indicate that cAMP is not the intracellular second messenger for Sm-C in cartilage. The data for cGMP are provocative and suggest it as a candidate for a second messenger mediating a portion of Sm's stimulation of cartilage metabolism.
Diagnosing Failures in Wireless Networks Using Fault Signatures (2010)

Detection and diagnosis of failures in wireless networks is of crucial importance. It is also a very challenging task, given the myriad of problems that plague present day wireless networks. A host of issues such as software bugs, hardware failures, and environmental factors, can cause performance degradations in wireless networks. As part of this study, we propose a new approach for diagnosing performance degradations in wireless networks, based on the concept of ``fault signatures''. Our goal is to construct signatures for known faults in wireless networks and utilize these to identify particular faults. Via preliminary experiments, we show how these signatures can be generated and how they can help us in diagnosing network faults and distinguishing them from legitimate network events. Unlike most previous approaches, our scheme allows us to identify the root cause of the fault by capturing the state of the network parameters during the occurrence of the fault.
The kinetics and mechanism of the electrophilic substitution of heteroaromatic compounds. Part XXXIX. Transmission of substituent effects in the pyridine system: Hammett-like treatment of hydrogenexchange data (1974)

Hydrogen-exchange rate constants for pyridines and for benzenes are correlated by the same equation provided that interactions between substituents are allowed for by ΣΠσ+. The derived equation permits the calculation of rate constants for polysubstituted benzenes and pyridines with reactivities covering 17 log units; the significance of this equation as representing something more than an empirical relationship is however in considerable doubt.
Correlation Between FAK Expression and Invasion and Metastasis of Colorectal Cancer (2003)

Objective To investigate the correlation between focal adhesion kinase(FAK) expression and carcinogenesis and biological behavior of colorectal cancer(CRC).Methods The expression of FAK was examined in specimens of 67 CRCs,paired normal colorectal mucosae and 37 regional lymph nodes metastases by immunohistochemical(SP) method.Results Positive rate of FAK expression in normal colorectal mucosae,CRCs and regional lymph node metastases was 71.6%(48/67)?89.6%(60/67) and 97.3%(36/37) respectively(P=0.001);Strong positive rate of FAK expression was 6.0%(4/67)?77.6%(52/67) and 83.8%(31/37) respectively(P=0.000).Positive rate of FAK expression in CRCs with and without regional lymph nodal metastasis was 100.0%(37/37) and 76.7%(23/30) respectively(P=0.007).Strong positive rate of FAK expression was 89.2%(33/37) and 63.3%(19/30) respectively(P=0.012).Expression levels of FAK,showing no correlation with the differentiation of CRC(P=0.438),was positively correlated with the invasive depth of CRC(P=0.009).Conclusion Increased expression of FAK can accelerate the proliferation,invasion and metastasis of malignant cells in CRC.Detection of FAK expression in biopsied colorectal mucosae and cancer tissues can be helpful to understand the carcinogenic tendency of colorectal mucosa and biological behavior of CRC as well as to make judgment of patient′s prognosis.
An Efficient General Synthesis of 1-Amino-2-naphthalenecarboxylic Acid Derivatives Based on a Tandem Conjugate Addtion-Enolate Nitrile Coupling Sequence (1996)

Abstract Reaction of o-(α-lithioalkyl)benzonitriles with α,β-unsaturated carboxylic acid derivatives produced 1-amino-3,4-dihydro-2-naphthalenecarboxylic acid derivatives through the tandem conjugate addition-enolate nitrile coupling sequence, which in turn were converted into 1-amino-2-naphthalenecarboxylic acid derivatives on dehydrogenation with palladium on activated carbon.
Contrast Enhanced Ultrasound as a Radiation-Free Alternative to Fluoroscopic Nephrostogram for Evaluating Ureteral Patency (2017)

A contrast enhanced ultrasound nephrostogram can be safely performed to evaluate for ureteral patency following percutaneous nephrolithotomy. This imaging technique was mostly concordant with fluoroscopic findings. Most discordance was likely attributable to the higher sensitivity for patency of contrast enhanced ultrasound compared to fluoroscopy.
Weight Gain and the Risk of Developing Insulin Resistance Syndrome (1998)

The odds of having developed the hemodynamic and metabolic abnormalities that characterize insulin resistance syndrome by middle adulthood were increasingly higher the greater the weight gain over the preceding 30 years. This study adds to the literature identifying deleterious effects of weight gain from young to middle adulthood.
Efficient Synthesis of Nucleosides Labeled with Stable Isotopes and Their Application to Structural Biology (1999)

1) A series of synthetic works on nucleosides appropriately labeled with stable isotopes of deuterium, carbon-13, and nitrogen-15 has been undertaken, confronting the strong demands for the nucleosides in the NMR spectroscopic study deeply related to structural biology, and the synthetic methods of (2'R)- and (2'S)-2'-deoxy[2'-2H]ribonucleosides, 2'-deoxy[5'-2H]ribonucleosides, [5'-13C]ribonucleosides, 2'-deoxy[5'-13C]ribonucleosides, 2'-deoxy[4-15N]cytidine, [4-15N]cytidine, 2'-deoxy[6-15N]adenosine, and [6-15N]adenosine were developed more efficiently than ever; some oligodeoxyribonucleotides were constructed by the use of these materials and found to be extraordinarily feasible for the NMR spectroscopic studies. 2) A novel approach to oligonucleotide synthesis on CPG has been established by the use of a base-labile protecting group, i.e., 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) protecting group for the 5'-hydroxyl group of nucleoside 3'-phosphoramidites.
Bubble measurement in three‐phase fluidized beds using a u‐shaped optical fiber (1984)

Abstract A photometric technique is being developed to study bubble behaviour in three‐phase fluidized beds constituted by fine particles. A custom made U‐shaped single core silica fiber (400 μm diameter) is used as the bubble sensor. A helium‐neon laser beam is introduced at one end of the U probe and the variation of the light intensity, occurring when a gas bubble contacts the sensor, is detected at the other end of the fiber. The velocity and axial length (cord) of the bubbles were measured by four such probes in a two dimensional bed. This technique could be applied to study the bubble behaviour and to provide experimental data for estimating the performance of reactors with severe operating conditions of high temperature and pressure.
ChemInform Abstract: Synthesis of Benzimidazole Derivatives as Antiallergic Agents with 5‐Lipoxygenase Inhibiting Action. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The New Mexico State University motion room (1990)

This article describes the construction and operation of a totally enclosed motion room capable of carrying four students. The room is used for studying motion in a rotating frame. The rotation rate can be varied from 0 to above 20 rpm. Unique features of this motion room are the 60-in. searchlight frame used for the mount and electrical connections and the two cattle watering troughs used for the motion room proper. The room, built a number of years ago, has not previously been described in the literature.
Visual outcome of excimer laser photorefractive keratectomy for myopia: A comparison of three laser delivery systems in Australia (1995)

Statistically comparable results were found in the three groups in terms of refraction and visual acuity six months after myopic photorefractive keratectomy. No statistical differences were found between the groups in terms of significant overcorrection or loss of best corrected acuity. The group treated using the Summit system demonstrated significantly greater regression than the other groups, necessitating larger initial hyperopic shifts.
Cadmium-induced ethylene production and responses in Arabidopsis thaliana rely on ACS2 and ACS6 gene expression (2014)

Cadmium induced the biosynthesis of ACC and ethylene in Arabidopsis thaliana plants mainly via the increased expression of ACS2 and ACS6. This was confirmed in the acs2-1acs6-1 double knockout mutants, which showed a decreased ethylene production, positively affecting leaf biomass and resulting in a delayed induction of ethylene responsive gene expressions without significant differences in Cd contents between wild-type and mutant plants.
Size, Biomass, and Nitrogen Relationships with Sweet Orange Tree Growth (2006)

Growth and nitrogen (N) accumulation relationships based on tree size, rather than age, may provide more generic information that could be used to improve sweet orange [ Citrus sinensis (L.) Osbeck] N management. The objectives of this study were to determine how orange trees accumulate and distribute biomass and N as they grow, investigate yearly biomass and N changes in mature orange trees, determine rootstock effect on biomass and N distribution, and to develop simple mathematical models describing these relationships. Eighteen orange trees with canopy volumes ranging between 2 and 43 m 3 were dissected into leaf, twig, branch, and root components, and the dry weight and N concentration of each were measured. The N content of each tree part was calculated, and biomass and N distribution throughout each tree were determined. The total dry biomass of large (mature) trees averaged 94 kg and contained 0.79 kg N. Biomass allocation was 13% in leaves, 7% in twigs, 50% in branches/trunk, and 30% in roots. N allocation was 38% in leaves, 8% in twigs, 27% in branches/trunk, and 27% in roots. For the smallest tree, above-/below-ground distribution ratios for biomass and N were 60/40 and 75/25, respectively. All tree components accumulated biomass and N linearly as tree size increased, with the above-ground portion accumulating biomass about 2.5 times faster than the below-ground portion due mostly to branch growth. The growth models developed are currently being integrated in a decision support system for improving fertilizer use efficiency for orange trees, which will provide growers with a management tool to improve long-term N use efficiency in orange orchards.
Quantitative T2 mapping accelerated by GRAPPATINI for evaluation of muscles in patients with myositis (2019)

GRAPPATINI acceleration makes T2 mapping feasible in clinical practice in providing quantitative information regarding thigh muscle inflammation in DM and PM.
A robust differential logic style with NMOS logic nets (1997)

In this paper a new dynamic differential logic style is presented. A non-precharged single phase clocking scheme is used. The logic is suitable for high speed and low power operation in both bit-serial and bit-parallel implementations, since all logic nets are purely in NMOS and merged with the latches. The logic style is also robust for clock slope and yield a data noise margin equal to Vdd/2.
A possible mechanism by which Protein Kinase B is phosphorylated at Ser473 (1999)

Conference Abstract| June 01 1999 A possible mechanism by which Protein Kinase B is phosphorylated at Ser473 Anudharan Balendran; Anudharan Balendran 1MRC Protein Phosphorylation Unit, Dept of Biochemistry, University of Dundee, Dundee DD1 5EH Search for other works by this author on: This Site PubMed Google Scholar Antonio Casamayor; Antonio Casamayor 1MRC Protein Phosphorylation Unit, Dept of Biochemistry, University of Dundee, Dundee DD1 5EH Search for other works by this author on: This Site PubMed Google Scholar Dario Alessi Dario Alessi 1MRC Protein Phosphorylation Unit, Dept of Biochemistry, University of Dundee, Dundee DD1 5EH Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1999) 27 (3): A106. https://doi.org/10.1042/bst027a106b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Anudharan Balendran, Antonio Casamayor, Dario Alessi; A possible mechanism by which Protein Kinase B is phosphorylated at Ser473. Biochem Soc Trans 1 June 1999; 27 (3): A106. doi: https://doi.org/10.1042/bst027a106b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1999 Biochemical Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.
Scaling a monitoring infrastructure for the Akamai network (2010)

We describe the design of, and experience with, Query, a monitoring system that supports the Akamai EdgePlatform. Query is a foundation of Akamai's approach to administering its distributed computing platform, allowing administrators, operations staff, developers, customers, and automated systems near real-time access to data about activity in Akamai's network. Users extract information regarding the current state of the network via a SQL-like interface. Versions of Query have been deployed since the inception of Akamai's platform, and it has scaled to support a distributed platform of 60,000+ servers, collecting over 200 gigabytes of data and answering over 30,000 queries approximately every 2 minutes.
The Importance of the Nitrous Oxide Pathway to NOx in Lean-Premixed Combustion (1993)

This study addresses the importance of the different chemical pathways responsible for NOx formation in lean-premixed combustion, and especially the role of the nitrous oxide pathway relative to the traditional Zeldovich pathway. NOx formation is modeled and computed over a range of operating conditions for the lean-premixed primary zone of gas turbine engine combustors. The primary zone, of uniform fuel-air ratio, is modeled as a micro-mixed well-stirred reactor, representing the flame zone, followed by a series of plug flow reactors, representing the post-flame zone. The fuel is methane. The fuel-air equivalence ratio is varied from 0.5 to 0.7. The chemical reactor model permits study of the three pathways by which NOx forms, which are the Zeldovich, nitrous oxide, and prompt pathways. Modeling is also performed for the well-stirred reactor alone. Three recently published, complete chemical kinetic mechanisms for the C1-C2 hydrocarbon oxidation and the NOx formation are applied and compared. Verification of the model is based on the comparison of its NOx output to experimental results published for atmospheric pressure jet-stirred reactors and for a ten atmosphere porous-plate burner. Good agreement between the modeled results and the measurements is obtained for most of the jet-stirred reactor operating range. For the porous-plate burner, the model shows agreement to the NOx measurements within a factor of two, with close agreement occurring at the leanest and coolest cases examined. For lean-premixed combustion at gas turbine engine conditions, the nitrous oxide pathway is found to be important, though the Zeldovich pathway cannot be neglected. The prompt pathway, however, contributes small-to-negligible NOx. Whenever the NOx emission is in the 15 to 30ppmv (15% O2, dry) range, the nitrous oxide pathway is predicted to contribute 40 to 45% of the NOx for high pressure engines (30atm), and 20 to 35% of the NOx for intermediate pressure engines (10atm). For conditions producing NOx of less than 10ppmv (15% O2, dry), the nitrous oxide contribution increases steeply and approaches 100%. For lean-premixed combustion in the atmospheric pressure jet-stirred reactors, different behavior is found. All three pathways contribute; none can be dismissed. No universal behavior is found for the pressure dependence of the NOx. It does appear, however, that lean-premixed combustors operated in the vicinity of 10atm have a relatively weak pressure dependence, whereas combustors operated in the vicinity of 30atm have an approximately square root pressure dependence of the NOx.
Inhibition of Gene Expression by Ribozymes William W. Hauswirth, Lynn C. Shaw, Patrick O. Whalen, Jason J. Fritz, (2003)

RNA enzymes, or ribozymes, can be defined as RNA molecules that promote a variety of reactions involving RNA and DNA molecules. These include site-specific cleavage, ligation, polymerization, and phosphoryl exchange (1). The use of ribozymes for medical therapy was recognized soon after RNA catalysis was discovered in the early 1980s (2). Three broad classes, naturally occurring ribozymes have been recognized: (1) RNase P, required for tRNA processing; (2) self-splicing introns, including group I and II introns of bacteria, mitochondria, and chloroplasts; and (3) selfcleaving viral agents, including hepatitis delta virus and components of plant viroids that cleave the RNA genome during replication. Because of their small size and great specificity, the self-cleaving ribozymes have the greatest potential for medical applications. The ability of these ribozymes to cleave other RNA molecules at specific sites makes them useful as inhibitors of viral replication or of cell proliferation (3-8).
A nanoparticle therapeutic vaccine targeting HAAH stimulates cellular immunity (2015)

Meeting abstracts We are evaluating the immunogenicity and efficacy of a nanoparticle vaccine (NPV) targeting the tumor marker human aspartyl (asparaginyl) β-hydroxylase (HAAH). HAAH is an embryonic protein that is over-expressed on the surface of cancer cells, is demonstrated to be responsible
Evaluating the Ecological Impacts of Cultivating Genetically Modified Herbicide Tolerant (GMHT) Oilseed Rape and Maize: (2007-B-DS-1-S1) STRIVE Report (2011)

This report is published as part of the Science, Technology, Research and Innovation for the\nEnvironment (STRIVE) Programme 2007–2013.
Dietary Long-Chain Omega-3 Fatty Acids Do Not Diminish Eosinophilic Pulmonary Inflammation in Mice (2013)

Although the effects of fish oil supplements on airway inflammation in asthma have been studied with varying results, the independent effects of the fish oil components, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), administered separately, are untested. Here, we investigated airway inflammation and hyperresponsiveness using a mouse ovalbumin exposure model of asthma assessing the effects of consuming EPA (1.5% wt/wt), DHA (1.5% wt/wt), EPA plus DHA (0.75% each), or a control diet with no added omega-3 polyunsaturated fatty acids. Consuming these diets for 6 weeks resulted in erythrocyte membrane EPA contents (molar %) of 9.0 (± 0.6), 3.2 (± 0.2), 6.8 (± 0.5), and 0.01 (± 0.0)%; DHA contents were 6.8 (± 0.1), 15.6 (± 0.5), 12.3 (± 0.3), and 3.8 (± 0.2)%, respectively. The DHA group had the highest bronchoalveolar lavage (BAL) fluid eosinophil and IL-6 levels (P < 0.05). Similar trends were seen for macrophages, IL-4, and IL-13, whereas TNF-α was lower in omega-3 polyunsaturated fatty acid groups than the control (P < 0.05). The DHA group also had the highest airway resistance, which differed significantly from the EPA plus DHA group (P < 0.05), which had the lowest. Oxylipins were measured in plasma and BAL fluid, with DHA and EPA suppressing arachidonic acid-derived oxylipin production. DHA-derived oxylipins from the cytochrome P450 and 15-lipoxygenase pathways correlated significantly with BAL eosinophil levels. The proinflammatory effects of DHA suggest that the adverse effects of individual fatty acid formulations should be thoroughly considered before any use as therapeutic agents in asthma.