gebhart/patrepeval huggingface dataset:
Pyrazolyl-bridged iridium dimers. 4. Two-fragment, two-center oxidative addition of halogens and methyl halides to trans-bis(triphenylphosphine)dicarbonylbis(.mu.-pyrazolyl)diiridium(I) (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrazolyl-bridged iridium dimers. 4. Two-fragment, two-center oxidative addition of halogens and methyl halides to trans-bis(triphenylphosphine)dicarbonylbis(.mu.-pyrazolyl)diiridium(I)Jerry L. Atwood, Kathy A. Beveridge, Gordon W. Bushnell, Keith R. Dixon, Donald T. Eadie, Stephen R. Stobart, and Michael J. ZaworotkoCite this: Inorg. Chem. 1984, 23, 24, 4050–4057Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/ic00192a042https://doi.org/10.1021/ic00192a042research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Brief overview of selected approaches in targeting pancreatic adenocarcinoma (2014)

Although studies into novel biomarkers and advanced imaging have highlighted the potential new avenues toward discovering localized tumors earlier, the current therapeutic options highlight the fact that PDAC is a highly metastatic and chemoresistant cancer that often must be fought with virulent, systemic therapies. Several newer approaches, including siRNA targeting of mutated KRas and enzymatic depletion of hyaluronan with PEGylated hyaluronidase are particularly exciting given their early stage results. Further research should help in elucidating their potential impact as therapeutic options.
Image enhancement using the adaptive correlation enhancer (1992)

Results from using a novel two-dimensional adaptive filtering algorithm to enhance two-dimensional signals of small spatial extent in noisy images are presented. The algorithm is called the two-dimensional adaptive correlation enhancer (2DACE). The 2DACE algorithm is a coefficient update scheme that converges to the two-dimensional autocorrelation function of the signal or feature of interest. Results are compared to images processed using the two-dimensional least mean square (LMS) algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Autonomic Arousal Index: an Automated Detection Based on Peripheral Arterial (2002)

Summary: Arousals from sleep are associated with increased sympathetic activation and are therefore associated with peripheral vasoconstriction. We hypothesized that digital vasoconstrictions as measured by peripheral arterial tonometery (PAT), combined with an increase in pulse rate, would accurately reflect arousals from sleep, and can provide an autonomic arousal index (AAI). Based on a previously studied group of 40 sleep apnea patients simultaneously recorded by both polysomnography (PSG) and PAT systems, an automated algorithm using the PAT signal (and pulse rate derived from it) was developed for detection of arousals from sleep. This was further validated in a separate group of 96 subjects (85 patients referred with suspected obstructive sleep apnea and 11 healthy volunteers mean age 46.2±14.4 years, BMI 28.5±5.4 kg/m 2 ). All underwent a whole night PSG with simultaneous PAT recording. The PSG recordings were blindly manually analyzed for arousals based on American Academy of Sleep Medicine (AASM) criteria, while PAT was scored automatically. There was a significant correlation between PSG and PAT arousals (R=0.82, p<0.0001) with a good agreement across a wide range of values, with a ROC curve having an area under the curve (AUC) of 0.88. We conclude that automated analysis of the peripheral arterial tonometry signal can detect EEG arousals from sleep, in a relatively quick and reproducible fashion.
Physical optics analysis of the focusing grating coupler (1988)

Fourier optics and waveguide theory are used to develop a numerical procedure to calculate performance of the focusing chirped grating. This device is of interest in development of an integrated optical data head. The method considers diffraction, aberrations, nonuniform illumination, and the effect of the grating boundary.
Topological Defect and Edge in Graphite. Nanometer Effect on .PI. Electron System. (1998)

We discuss the n electronic states of a graphite sheet which has topological defects or edges on a nanometer scale. The former is the case that pairs of pentagonal and heptagonal rings are introduced in the hexagonal network of a graphite sheet. In the latter case, we take notice of nanographite, which is a kind of graphite fragment of a nanometer size. Through the whole, we demonstrate how the π electronic states vary under the control of the nanometer topology of the three-coordinated π-electron network in a graphite sheet.
DBpediaNYD: a silver standard benchmark dataset for semantic relatedness in DBpedia (2013)

Abstract. Determining the semantic relatedness (i.e., the strength of a relation) of two resources in DBpedia (or other Linked Data sources) is a problem addressed by quite a few approaches in the recent past. However, there are no large-scale benchmark datasets for comparing such approaches, and it is an open problem to determine which of the approaches work better than others. Furthermore, larget-scale datasets for training machine learning based approaches are not available. DBpedia-NYD is a large-scale synthetic silver standard benchmark dataset which supports contains symmetric and asymmetric similarity values, obtained using a web search engine.
Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin. (1991)

In serine proteases, residue 192, three residues prior to the active site Ser-195, plays an important role in determining substrate specificity. In trypsin (EC 3.4.21.4) and most trypsin-like enzymes with relatively broad specificity, this position is occupied by Gln. In thrombin (EC 3.4.21.5), an enzyme with restricted specificity, position 192 is occupied by Glu. The potential importance of Glu-192 in restricting the specificity of thrombin was investigated by isosterically replacing Glu-192 with Gln. Unlike trypsin, thrombin cleavage of peptides with acidic residues in positions P3 and P'3 [where P3 and P'3 refer to three residues removed from the Arg (P1) cleavage site on the amino and carboxyl side, respectively] is inefficient. Protein C, an anticoagulant zymogen, has Asp residues in positions P3 and P'3. Thrombomodulin, an endothelial cell protein, complexes with thrombin to activate protein C rapidly thus altering the specificity of thrombin. Compared to thrombin, the Glu-192----Gln mutant thrombin activates protein C 22 times more rapidly and cleaves the P7-P'5 peptide from the protein C activation site 19 times faster. Enhanced protein C activation results primarily from an increase in the catalytic rate constant rather than an improved Michaelis constant, a property that is shared by the thrombin-thrombomodulin complex. The Glu-192----Gln mutation does not influence fibrinopeptide A release and only increases the rate of fibrinopeptide B release 2.7-fold. These results demonstrate that Glu-192 plays a critical role in restricting the specificity of thrombin and suggest that thrombomodulin may function in part by altering the enzyme-substrate interaction near residue 192 in thrombin.
ChemInform Abstract: NMR Kinetic Studies on the Decomposition of β‐Amidozinc Reagents: Optimization of Palladium‐Catalyzed Cross‐Coupling with Acid Chlorides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Comparison of Thiopental Sodium and Propofol as an Induction Agent in Propofol-N2O Anesthesia for Cesarean Sections (2001)

We compared thiopental sodium with propofol as induction agents under propofol-N2O anesthesia for cesarean sections.
Accelerated MR imaging using compressive sensing with no free parameters (2012)

We describe and evaluate a robust method for compressive sensing MRI reconstruction using an iterative soft thresholding framework that is data-driven, so that no tuning of free parameters is required. The approach described here combines a Nesterov type optimal gradient scheme for iterative update along with standard wavelet-based adaptive denoising methods, resulting in a leaner implementation compared with the nonlinear conjugate gradient method. Tests with T₂ weighted brain data and vascular 3D phase contrast data show that the image quality of reconstructions is comparable with those from an empirically tuned nonlinear conjugate gradient approach. Statistical analysis of image quality scores for multiple datasets indicates that the iterative soft thresholding approach as presented here may improve the robustness of the reconstruction and the image quality, when compared with nonlinear conjugate gradient that requires manual tuning for each dataset. A data-driven approach as illustrated in this article should improve future clinical applicability of compressive sensing image reconstruction.
Corrosion Behavior of Thin Wall Magnesium Products Molded by Thixomolding (2000)

In this paper, the corrosion behavior of thin wall Mg products including commercial housings were evaluated by salt spray and electrochemical testing. The effect of thickness and direction of the melt flow were then discussed.
DECREASED OXIDANT BUFFERING IMPAIRS NF-κB ACTIVATION AND ICAM-1 TRANSCRIPTION IN ENDOTHELIAL CELLS (2001)

The DNA binding activity of the transcription factor, NF-kappaB, is regulated by the phosphorylation and degradation of its inhibitory protein, IkappaB, and post-translational modification involving redox reaction of a cysteine residue (Cys62) of NF-kappaB. We addressed the role of the redox state of endothelial cells in modulating TNFalpha-induced NF-kappaB activity. The effects of TNFalpha on DNA-binding activity of NF-kappaB and expression of mRNA encoding ICAM-1 (an NF-kappaB-activated gene) were studied in human pulmonary artery endothelial (HPAE) cells under basal conditions and after decreasing the intracellular glutathione (GSH) concentration. HPAE cells were treated with buthionine sulfoximine (BSO) (16 h), an inhibitor of GSH synthesis, which caused concentration-dependent decreases in GSH concentration. Stimulation of control cells with TNFalpha resulted in reactive oxygen species (ROS) generation and activation of NF-kappaB binding to the ICAM-1 promoter and ICAM-1 transcription. However, stimulation of GSH-depleted cells with TNFalpha resulted in ROS accumulation secondary to the decreased ROS buffering capacity, and marked impairment of NF-kappaB-binding activity and ICAM-1 mRNA expression. Exposure of BSO-treated cells to the reducing agent dithiothreitol (DTT) before TNFalpha treatment or supplementation of nuclear extract (isolated after TNFalpha challenge of BSO-treated cells) with DTT significantly augmented the effect of TNFalpha on NF-kappaB-binding activity and ICAM-1 mRNA expression. Thus the oxidative modification of NF-kappaB secondary to the loss of ROS buffering capacity may regulate NF-kappaB binding to ICAM-1 promoter, and thereby ICAM-1 transcription in endothelial cells.
Electrochemical growth of superparamagnetic cobalt clusters (1995)

The magnetization of stabilized cobalt colloids in tetrahydrofuran has been studied by a superconducting quantum interference device (SQUID) and magnetic balance measurements in dependence of applied magnetic field and temperature. The colloids are generated by a newly developed electrochemical method which allows one to generate clusters containing about 1000 atoms with a narrow size distribution. The final size distribution of the clusters is examined by high resolution transmission electron microscopy and small angle x-ray scattering. The magnetization curves have been determined with special emphasis on changes at the freezing point of the solution. The curves of the liquid phase can be reasonably described by the Langevin function and the magnetic moments of isolated cobalt clusters that have been recently measured by Stern–Gerlach experiments. Deviations that appear at the freezing point can be understood in terms of magnetic anisotropy effects. It is shown that the cluster sizes and the susceptibilities of the dispersions are related. Therefore the growth of the clusters during the electrolysis can be directly observed by measuring the susceptibility in dependence of the charge transport in the cell.
MULTIMODAL THERAPY FOR STAGE IV ADULT WILMS TUMOR (2001)

No AccessJournal of UrologyCLINICAL UROLOGY: Case Reports1 Apr 2001MULTIMODAL THERAPY FOR STAGE IV ADULT WILMS TUMOR GANESH V. RAJ, SCOTT K. PRUITT, SCOTT LILLY, JOHN T. MADDEN, and DAVID T. PRICE GANESH V. RAJGANESH V. RAJ More articles by this author , SCOTT K. PRUITTSCOTT K. PRUITT More articles by this author , SCOTT LILLYSCOTT LILLY More articles by this author , JOHN T. MADDENJOHN T. MADDEN More articles by this author , and DAVID T. PRICEDAVID T. PRICE More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66473-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "MULTIMODAL THERAPY FOR STAGE IV ADULT WILMS TUMOR." The Journal of Urology, 165(4), p. 1202 References 1 : Adult Wilms’ tumor: prognosis and management considerations. Urology1995; 45: 1055. Google Scholar 2 : Salvage therapy in metastatic adult Wilms’ tumor. Cancer1988; 62: 1017. Google Scholar 3 : Adult Wilms’ tumour: review of 22 cases. Eur J Cancer1994; 30A: 1778. Google Scholar From the Division of Urology, Departments of Surgery, Medicine and Pathology, Duke University Medical Center, Durham, North Carolina© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 165Issue 4April 2001Page: 1202 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordskidneynephroblastomaneoplasm metastasisdrug therapy, combinationliverMetricsAuthor Information GANESH V. RAJ More articles by this author SCOTT K. PRUITT More articles by this author SCOTT LILLY More articles by this author JOHN T. MADDEN More articles by this author DAVID T. PRICE More articles by this author Expand All Advertisement PDF downloadLoading ...
Optical 3-D omega networks (1991)

With the increasing demand for solving computation-intensive tasks such as image processing and image understanding, a volume (3-D), dynamic multistage interconnection network that interconnects a 2-D array of channels to another is desirable. 1 The understanding of the properties of these networks and their relationships is important for constructing useful; 3-D networks. Here, we study the class of 3-D Omega networks based on different shuffling principles and arrangements of the switch elements. The results show that the 3-D Omega networks using 2-D folded shuffles combined with 2×2 bypass/exchange switch element arrays2 in the 2-D plane are either topologically identical or equivalent to 2-D Omega networks using 1-D perfect shuffles combined with 2×2 bypass/exchange switch element arrays. Networks using 2-D separable shuffles combined with 2×2 bypass/exchange switch element arrays are full access only for a particular arrangement of the switch element arrays at the stages. A reduced-state 4×4 switch element, formed by four 2×2 switch elements with one pair lying horizontally, the other pair standing vertically and a direct connection between the two pairs, can be used at each stage. When reduced-state 4×4 switch element arrays are used, 3-D Omega networks with 2-D folded shuffles and 2-D separable shuffles are topologically identical.
Characterization of CdTe crystals grown under microgravity conditions (1989)

The electrical properties of two types of CdTe crystals grown in space (solution and vapour phase) were investigated and compared with those of control samples, grown under the same thermal conditions on earth. The study shows that crystals grown in space contain smaller concentrations of electrically active defects and exhibit higher mobility-lifetime products, higher resistivities and better nuclear detection properties. Space growth of CdTe is thus shown to be a promising method for obtaining high quality, detector-grade CdTe material.
Understanding Chemical Expansion in Non‐Stoichiometric Oxides: Ceria and Zirconia Case Studies (2012)

Abstract Atomic scale computer simulations, validated with experimental data, are used to uncover the factors responsible for defect‐induced chemical expansion observed in non‐stoichiometric oxides, exemplified by CeO 2 and ZrO 2 . It is found that chemical expansion is the result of two competing processes: the formation of a vacancy (leading to a lattice contraction primarily due to electrostatic interactions) and the cation radius change (leading to a lattice expansion primarily due to steric effects). The chemical expansion coefficient is modeled as the summation of two terms that are proportional to the cation and oxygen radius change. This model introduces an empirical parameter, the vacancy radius, which can be reliably predicted from computer simulations, as well as from experimental data. This model is used to predict material compositions that minimize chemical expansion in fluorite structured solid oxide fuel cell electrolyte materials under typical operating conditions.
Risk Analysis of Thrombo-Embolic and Recurrent Bleeding Events in the Management Of Intracranial Haemorrhage Due to Oral Anticoagulation (2005)

In OAC-related intracranial haemorrhages, OAC can be stopped safely for a considerable period, with a very low overall thrombotic event rate. The recurrent bleeding risk after restarting OAC is low. Recurrent bleeding mostly occurred before restarting OAC and is probably caused by insufficient or unsustained correction of the initial coagulation deficit. Immediate reversal of anticoagulation provides the patient with the best possible treatment options including surgery. OAC-related intracranial haemorrhages can therefore be actively treated.
Improvement of Efficacy of Antitumor Agents by Conagenin. (1995)

The antitumor efficacy of antitumor agents at sublethal doses was investigated in combination with conagenin (CNG) against murine leukemias. Mice were inoculated with 1 x 10(3) L1210 cells i.v. and given 300 mg/kg of cyclophosphamide (CY) i.p. on days 1 and 2 or on days 1, 5 and 9 after the tumor inoculation, and 5 mg/kg of CNG daily for 10 days. The administration of CNG was effective in increasing the number of cured mice and in prolonging the survival period of mice significantly, on both schedules of CY treatment. Moreover, the antitumor effect of CY against EL-4 was enhanced by CNG in increasing the number of cured mice, in CY treatment on days 1 and 2, and on days 1, 5 and 9. The effect of CNG was examined with mitomycin C (MMC) and adriamycin (ADM) at sublethal doses against leukemias. The antitumor effects of MMC at 10 mg/kg against L1210, and ADM at 15 mg/kg against P388 administered on days 1 and 5 were enhanced by CNG. Although mice treated with ADM at 15 mg/kg died earlier than non-treated controls on days 1 and 2 against L1210, P388 and EL-4, CNG with ADM was effective in prolonging the survival period.
European Society of Hypertension practice guidelines for ambulatory blood pressure monitoring (2014)

Given the increasing use of ambulatory blood pressure monitoring (ABPM) in both clinical practice and hypertension research, a group of scientists, participating in the European Society of Hypertension Working Group on blood pressure monitoring and cardiovascular variability, in year 2013 published a comprehensive position paper dealing with all aspects of the technique, based on the available scientific evidence for ABPM. The present work represents an updated schematic summary of the most important aspects related to the use of ABPM in daily practice, and is aimed at providing recommendations for proper use of this technique in a clinical setting by both specialists and practicing physicians. The present article details the requirements and the methodological issues to be addressed for using ABPM in clinical practice, The clinical indications for ABPM suggested by the available studies, among which white-coat phenomena, masked hypertension, and nocturnal hypertension, are outlined in detail, and the place of home measurement of blood pressure in relation to ABPM is discussed. The role of ABPM in pharmacological, epidemiological, and clinical research is also briefly mentioned. Finally, the implementation of ABPM in practice is considered in relation to the situation of different countries with regard to the reimbursement and the availability of ABPM in primary care practices, hospital clinics, and pharmacies.
Improved Word-Level System Combination for Machine Translation (2007)

Recently, confusion network decoding has been applied in machine translation system combination. Due to errors in the hypothesis alignment, decoding may result in ungrammatical combination outputs. This paper describes an improved confusion network based method to combine outputs from multiple MT systems. In this approach, arbitrary features may be added log-linearly into the objective function, thus allowing language model expansion and re-scoring. Also, a novel method to automatically select the hypothesis which other hypotheses are aligned against is proposed. A generic weight tuning algorithm may be used to optimize various automatic evaluation metrics including TER, BLEU and METEOR. The experiments using the 2005 Arabic to English and Chinese to English NIST MT evaluation tasks show significant improvements in BLEU scores compared to earlier confusion network decoding based methods. 1