gebhart/patrepeval huggingface dataset:
A new junction termination technique for power devices: resurf LDMOS with SIPOS layers (2005)

A new junction termination technique, combining the effect of a SIPOS layer with a RESURF principle is evaluated for a LDMOST by numerical analysis. It is shown that the drawbacks inherent to the RESURF principle, mainly the sensitivity to technological parameters, are bypassed by using a semi-resistive layer. Quantitative analysis shows that the breakdown voltage can be kept at its optimal value along with a consequent reduction of the On resistance of the device. Breakdown voltage and On resistance are calculated versus the oxide thickness, epi-thickness, and versus the dose and the junction depth of a surface implantation aimed to further reduce the On resistance of the RESURF LDMOS.
Urothelial Cells Malignantly Transformed by Exposure to Cadmium (Cd+2) and Arsenite (As+3) Have Increased Resistance to Cd+2 and As+3-Induced Cell Death (2006)

This laboratory has shown that both Cd(+2) and As(+3) can malignantly transform human urothelial cells. The present study examined metal resistance and the mechanism of cell death when the parental and malignantly transformed UROtsa cells were exposed to Cd(+2) and As(+3). It was shown that the malignantly transformed UROtsa cells were more resistant to the toxic effects of both metals. The assessment of the mode of cell death demonstrated that the parental UROtsa cells died by both apoptosis and necrosis when exposed to either metal. It was shown that apoptosis was the more prominent mechanism of cell death, accounting for over 50% of cell death. Apoptotic cell death was determined by the observation of fragmented nuclei using 4',6-diamidino-2-phenylindole staining, the formation of a DNA ladder, and the detection of cleaved caspase-3 and caspase-9 products in the cell lysates. Necrotic cell death was determined by measuring the release of lactate dehydrogenase into the growth medium. It was determined that the extent of apoptosis of the malignantly transformed UROtsa cells was decreased and that the extent of necrosis was increased compared to the parental UROtsa cells. These observations are consistent with in vivo studies which suggest that As(+3) can act as a tumor promoter during the regeneration of the bladder urothelium. The present in vitro studies suggest that As(+3)-induced cytotoxicity could set the stage for tissue repair due to its own inherent toxicity to normal urothelium, and then subsequently act as a tumor promoter during the regeneration process through the stimulation of the regrowth of cells that have gained increased resistance to As(+3).
A multiphase phase/frequency detector-based frequency synthesizer (2005)

The paper presents a multiphase phase/frequency detector for a PLL-based frequency synthesizer that shares the phase correction information N times in the period of an RF step. The multiphase PFD provides a better rejection of reference spurious tone and reduces the charge pump current without bandwidth and loop filter modification. The 800 MHz MPFD PLL has been implemented in a STMicroelectronics BiCMOS 2.5 V 0.25 /spl mu/m technology.
The calcium binding sites in human annexin V by crystal structure analysis at 2.0 A resolution Implications for membrane binding and calcium channel activity (1990)

Crystal structure analysis and refinement at 2.0 A resolution of a rhombohedral crystal form of human annexin V at high calcium concentration revealed a domain motion compared to the previously analysed hexagonal crystal form. Five calcium ions were located on the convex face of the molecule. Three strongly bound calciums are liganded at protruding interhelical loops and Asp or Glu residues in homologous positions in repeats I, II and IV. Five proteinaceous oxygens and one solvent molecule form the coordination polyhedron in each case. The unoccupied seventh site is suggested as the phospholipid headgroup binding site. Two more weakly bound sites were identified by lanthanum labelling. The structural features suggest that annexin V attaches with its convex face to membranes by specific calcium mediated interactions with at least three phospholipids. The adjacent membrane bilayer may thus become locally disordered and permeable to allow calcium inflow through the central polar channel of the molecule.
Brochure MWT cell- and module technology (2013)

Metal wrap-through (MWT) back contact cell- and module technology is a proven platform for lower cost of ownership and higher power output for wafer-based silicon solar modules. Read here more about MWT cell- and module technology and what ECN can do for you.
Solvent-Controlled Selectivity toward Exclusive C−C or C−H Bond Activation by a Cationic Metal Center (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSolvent-Controlled Selectivity toward Exclusive C−C or C−H Bond Activation by a Cationic Metal CenterBoris Rybtchinski and David MilsteinView Author Information Department of Organic Chemistry The Weizmann Institute of Science Rehovot, 76100, Israel Cite this: J. Am. Chem. Soc. 1999, 121, 18, 4528–4529Publication Date (Web):April 27, 1999Publication History Received4 February 1999Published online27 April 1999Published inissue 1 May 1999https://pubs.acs.org/doi/10.1021/ja990339phttps://doi.org/10.1021/ja990339prapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1328Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Chemical reactions,Metals,Solvents,Thermodynamics Get e-Alerts
Etude de la protection de lactames par le reactif de swern. Synthese d'un precurseurn de la partie nord de l'avermectine b2b (1992)

Cette these est constituee de deux parties independantes. La premiere decrit une etude de la o-methylthiomethylation d'amides de type 2-pyridone et apparentes par le chlorure de chlorodimethylsulfonium ou reactif de swern. La temperature ainsi que la concentration en reactif de swern constituent les deux facteurs importants qui affectent le rendement et la selectivite en produit de o-methylthiomethylation. Cette nouvelle methode de protection presente l'avantage d'etre rapide et peu onereuse par rapport aux methodes classiques utilisant les oxoniums de trialkyles ou les halogenures d'alkyles en presence de carbonate d'argent. La seconde partie concerne la synthese d'un precurseur spirocetalique de l'avermectine b2b. Une synthese enantioselective de la partie tetrahydropyrane est developpee en utilisant, comme source d'activite optique, une reaction d'epoxydation asymetrique. La methyl cetone cyclique ainsi obtenue est ensuite condensee sur un aldehyde correspondant au fragment acyclique c10-c17 pour conduire a deux aldols spirocycliques diastereoisomeres dont la stereochimie est actuellement a l'etude. Par ailleurs, une voie d'acces originale au systeme spirocyclique des avermectines, via un couplage organometallique au ni(0), a ete ebauchee
An Improved Chamber for the Short-Circuiting of Epithelia (1985)

ABSTRACT Since the pioneering work of Ussing & Zerahn (1951), the design of short-circuit apparatus has been modified only slightly. Such chambers generally consist of two halves, between which the epithelium is stretched. The assembly is clamped together and filled with saline, which is circulated in each half chamber by gas lift pumps, usually connected to the main chamber with plastic pipes. There are two current electrodes, one at each end of the chamber, and -usually -two voltage-sensing electrodes close to the tissue. The current passed through the chamber is adjusted until the p.d. between the sensing electrodes becomes zero. Under such conditions, only actively transported ions move across the tissue, and the short-circuit current is a precise measure of the net flux of charged species. Short-circuiting is thus a method of choice for investigating transport phenomena in epithelia.
Recalibrating survival prediction among patients receiving trans‐arterial chemoembolization for hepatocellular carcinoma (2021)

Abstract Background & Aims The Pre‐TACE‐Predict model was devised to assess prognosis of patients treated with trans‐arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). However, before entering clinical practice, a model should demonstrate that it performs a useful role. Methods We performed an independent external validation of the Pre‐TACE model in a cohort that differs in setting and time period from the one that generated the original model. Data from 826 patients treated with TACE for naïve HCC (2008‐2018) were used to assess calibration and discrimination of the Pre‐TACE‐Predict model. Results The four risk‐categories identified by the Pre‐TACE‐Predict model had gradient monotonicity, with median survivals of 52.0, 36.2, 29.9, and 14.1 months respectively. However, predicted survivals systematically underestimated observed survivals ( R 2 : 0.667). A recalibration was adopted maintaining fixed the prognostic index and modifying the baseline survival function. This resulted in an almost perfect calibration ( R 2 : 0.995) in all the four risk categories. Cox regressions showed that aetiology and macrovascular invasion, included in the Pre‐TACE‐Predict model, had no prognostic impact in the present study population, and that coefficients for tumour size and multiplicity were overestimated. The c ‐index was similar to that of the m‐HAP‐III, but higher than those of HAP, m‐HAP‐II and the six‐and‐twelve models. Conclusions The recalibration of Pre‐TACE‐Predict model improved the estimation of survival probabilities of HCC patients treated with TACE. The highest discriminatory ability of the Pre‐TACE‐model in comparison to other available models, together with risk stratification and recalibration, makes it the best prognostic tool currently available for these patients.
Preparative‐Scale Separation of C<sub>60</sub> and C<sub>70</sub> on Polystyrene Gel (1992)

Five grams of a mixture of C 60 /C 70 can be separated in 24 hours by gel permeation chromatography on polystyrene gel. The mobile phase can be completely recovered, and the method can be scaled up by a simple increase in the inner diameter of the column.
ChemInform Abstract: DIISOPHORONE AND RELATED COMPOUNDS. PART 7. SYNTHESES AND PROPERTIES OF 1‐HYDROXYDIISOPHOR‐2(7)‐ENE‐3,4‐DIONE (1981)

Abstract Die Titelverbindung (II) ist auf verschiedene Weise erhältlich.
Adverse Effects of Ureteral Stent and Development of the Antireflux Ureteral Stent (2013)

(ureteral stent) , double-J (D-J ) . 1967 Zimskind
Anisotropic surface impedance of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">YBa</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mi mathvariant="normal">−</mml:mi><mml:mi mathvariant="normal">δ</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>single crystals (1995)

The anisotropic surface resistance ${\mathit{R}}_{\mathit{s}\mathrm{\ensuremath{-}}\mathit{ab}}$ and ${\mathit{R}}_{\mathit{s}\mathrm{\ensuremath{-}}\mathit{c}}$ as well as the penetration depth ${\ensuremath{\lambda}}_{\mathit{ab}}$ and ${\ensuremath{\lambda}}_{\mathit{c}}$ of ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\delta}}}$ single crystals have been measured at 9.6 GHz. ${\ensuremath{\lambda}}_{\mathit{c}}$(T) and ${\ensuremath{\lambda}}_{\mathit{ab}}$(T) are linear in temperature at low temperatures with much different slopes, consistent with the existence of line nodes on a cylindrical Fermi surface. A collapse of the c-axis scattering rate below ${\mathit{T}}_{\mathit{c}}$ is also observed, and the temperature dependence of the ab plane scattering rate is consistent with quasiparticle-quasiparticle scattering. The behavior of ${\ensuremath{\lambda}}_{\mathit{c}}$(T) is not consistent with proximity-effect models, or with cubic ${\mathit{d}}_{{\mathit{x}}^{2}+{\mathit{y}}^{2}\mathrm{\ensuremath{-}}{\mathit{z}}^{2}}$ pairing symmetry, but is consistent with a cubic ${\mathit{d}}_{{\mathit{x}}^{2}\mathrm{\ensuremath{-}}{\mathit{y}}^{2}}$ pairing state.
Emissions of air toxics from coal-fired boilers: Arsenic (1994)

Concerns over emissions of hazardous air pollutants (air toxics) have emerged as a major environmental issue; the authority of the US Environmental Protection Agency to regulate such pollutants has been greatly expanded through passage of the Clean Air Act Amendments of 1990. Arsenic and arsenic compounds are of concern mainly because of their generally recognized toxicity. Arsenic is also regarded as one of the trace elements in coal subject to significant vaporization. This report summarizes and evaluates available published information on the arsenic content of coals mined in the United States, on arsenic emitted in coal combustion, and on the efficacy of various environmental control technologies for controlling airborne emissions. Bituminous and lignite coals have the highest mean arsenic concentrations, with subbituminous and anthracite coals having the lowest. However, all coal types show very significant variations in arsenic concentrations. Arsenic emissions from coal combustion are not well-characterized, particularly with regard to determination of specific arsenic compounds. Variations in emission, rates of more than an order of magnitude have been reported for some boiler types. Data on the capture of arsenic by environmental control technologies are available primarily for systems with cold electrostatic precipitators, where removals of approximately 50 to 98% have been reported. Limited data for wet flue-gas-desulfurization systems show widely varying removals of from 6 to 97%. On the other hand, waste incineration plants report removals in a narrow range of from 95 to 99%. This report briefly reviews several areas of research that may lead to improvements in arsenic control for existing flue-gas-cleanup technologies and summarizes the status of analytical techniques for measuring arsenic emissions from combustion sources.
Photochemical deposition of Platinum over MWNT: making catalysts for selective hydrogenation of cinnamaldehyde (2005)

In the present study, the photochemical deposition method was compared against the usual incipient wetness procedure in the preparation of supported Pt catalysts. Particular attention was given to parameters such as nature of the support (multiwalled carbon nanotubes, MWNT vs. titanium dioxide, TiO2) and reduction temperature. Supported 1% wt Pt catalysts treated in hydrogen at 773K showed improved activity and selectivity towards cinnamyl alcohol (50.8 and 57.4% were observed in MWNT and TiO2 - SMSI effect, respectively) when comparing to those untreated (45.8 and 28.9, MWNT and TiO2, respectively). The best catalytic performance was achieved by a 5% wt Pt supported in TiO2 catalyst treated in hydrogen at 773K. Selectivity to unsaturated alcohol as high as 63.2% at 80% conversion was observed.
Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity (2010)

Peloruside is a microtubule-stabilizing agent that targets the same site as laulimalide. It binds to microtubules with a 1:1 stoichiometry and with a binding affinity in the low-muM range; thereby reducing the number of microtubular protofilaments in the same way as paclitaxel. Although the binding affinity of the compound is comparable to that of the low-affinity stabilizing agent sarcodictyin, peloruside is more active in inducing microtubule assembly and is more cytotoxic to tumor cells; this suggests that the peloruside site is a more effective site for stabilizing microtubules. Acetylation of the C24 hydroxyl group results in inactive compounds. According to molecular modeling, this substitution at the C24 hydroxyl group presumably disrupts the interaction of the side chain with Arg320 in the putative binding site on alpha-tubulin. The binding epitope of peloruside on microtubules has been studied by using NMR spectroscopic techniques, and is compatible with the same binding site.
<i>Pastewella multocida</i> chorioamnionitis from vaginal transmission (1992)

A 21 year old primigravida with a twin pregnancy developed Pasteurella multocida chorioamnionitis. Infection occurred at 27 weeks gestational age after prolonged rupture of membranes. The twin in the separate sac presenting proximal to the cervix suffered infection and died shortly after birth whereas the other twin was not infected. The bacterium is believed to have caused ascending infection from asymptomatic colonization of the vaginal tract.
THE IMMUNOGENICITY OF ANTIGEN BOUND TO THE PLASMA MEMBRANE OF MACROPHAGES (1970)

Macrophages were cultured for several hours after a brief exposure to radio-iodinated keyhole limpet hemocyanin. Most of the hemocyanin taken up by the macrophages was rapidly catabolized and eliminated from the cell. A few molecules were retained on the plasma membrane of the cells for prolonged periods and were not subject to endocytosis and catabolism. These few molecules of hemocyanin bound to the plasma membrane were identified by observing the fixation of antibody fragments to macrophages at low temperature. The membrane-bound antigen, which could be removed by trypsin or EDTA, was of large molecular size, though heterogeneous. A great part of the immune responses of mice to hemocyanin bound to live macrophages could be abrogated by treatment of the macrophages in vitro with antibody or trypsin. Hence, most of the immunogenicity of hemocyanin bound to macrophages was attributed to the few molecules of antigen bound to the plasma membrane.
A modelling and simulation functional library for self-contained simulators (2004)

Self-contained simulators are a computer execution run-time unit that may simulate a behavior of a physical system. It may be used for simulation analysis, system optimization or cooperative simulation using different tools. Often communication problems arise when trying to combine several different engineering tools for co simulation. Every vendor of commercial engineering tools has their own preferences in communication techniques. By formulate the actual physical models in a XML-based tool independent format one get a powerful way of creating execution units that can be adopted for a set of engineering tools in a more general way. This paper exemplifies this approach. Also this work relates to our general efforts in method development for simulation, modeling and optimization of engineering system within mechatronics and actuation technologies. Within the framework of ModeLiTH a well defined XML formulation for tool independent modeling and simulation of dynamical systems has been described. This paper describes the general aspects of the modeling and simulation functional library, MSFL, used for creating self-contained simulators. This self-contained simulator concept represent one implementation of the lowest level of the ModeLiTH framework and has the potential to become the actual run-time execution unit of the ModeLiTH framework. However in this work the current implementation does not use the complete functionality of the ModeLiTH framework, instead a subset is used. Therefore no complete chain of system analysis suing the ModeLiTH can be shown. This paper summarizes the current state of the ongoing project.
[A method to produce the animal model of diabetic cardiomyopathy]. (2006)

The SD model rat appear the diabetic cardiomyopathy condition by injected the STZ (55mg/kg) at the left iliac region only once in 3 weeks. It is a simple and scientific method to produce the animal model of diabetic cardiomyopathy.
Stereoselective Chloro‐Deboronation Reactions Induced by Substituted Pyridine–Iodine Chloride Complexes (2005)

Abstract A novel class of charge‐transfer complexes based on iodine chloride and substituted pyridines, which possess a number of interesting and unique structural features, can be employed to bring about a stereocontrolled chloro‐deboronation of certain vinyl boronates to generate the (1 Z )‐alkenyl chlorides in good yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Synergistic inhibition of phorbol ester-induced transformation of JB6 cells by transforming growth factor-beta and retinoic acid. (1991)

Transforming growth factor-beta (TGF-beta) plays a complex role as a regulator of proliferation and differentiation of many cell types, including cells of epithelial origin. In this study, we examined whether TGF-beta, alone or in combination with retinoic acid, was able to inhibit the transformation of the murine epidermal cell line JB6. When treated with phorbol myristate acetate (PMA) and other tumor promoters, the nontumorigenic and anchorage-dependent JB6 cells acquired a tumor phenotype, as shown by the acquisition of tumorigenicity and anchorage independence. We found that TGB-beta inhibited the PMA-induced transformation of a subclone of JB6 cells. The effect of TGF-beta was due to an anti-transformation promoting activity, rather than to generalized growth inhibition, since TGF-beta neither inhibited the growth of monolayer cultures of JB6 cells, nor affected the colony-forming efficiency in agar of the JB6-derived permanently transformed RT101 cell line. TGF-beta was synergistic with retinoic acid, a known anti-tumor promoter, in inhibiting the PMA-induced transformation of JB6 cells. Examination of TGF-beta receptor expression on JB6 cells, by both binding and affinity labeling, showed that treatment with PMA significantly decreased TGF-beta receptor expression while retinoic acid counteracted this effect of PMA, thus suggesting that the synergy between retinoic acid and TGF-beta may be due, at least in part, to modulation of TGF-beta receptor expression. TGF-beta, therefore, appears to function as an incomplete antipromoter whose action can be permitted and/or complemented by retinoic acid. Our data demonstrating that TGF-beta has anti-transformation promoting activity suggest that TGF-beta plays a role in maintaining homeostasis of epithelial cells, not only by regulating cell proliferation and differentiation, but also by counteracting events that lead to malignant transformation.