gebhart/patrepeval huggingface dataset:
Identification and Characterization of Pathogenic <i>Aeromonas veronii</i> Biovar Sobria Associated with Epizootic Ulcerative Syndrome in Fish in Bangladesh (2002)

Sparse information is available on the virulence factors of Aeromonas strains isolated from diseased fish, from the environment, and from humans. In the present study, 52 Aeromonas isolates obtained from epizootic ulcerative syndrome (EUS) lesions in fish, from the aquatic environment, and from children with diarrhea in Bangladesh were identified by biochemical phenotyping (i.e., PhenePlate [PhP] typing) and DNA fingerprinting and then characterized with respect to certain putative virulence factors. The isolates from the fish exhibiting EUS symptoms were identified to be Aeromonas veronii biovar sobria by fatty acid methyl ester analysis and amplified fragment length polymorphism fingerprinting. Biochemical phenotyping revealed that all EUS-associated isolates belonged to a unique phenotype which was not identified among more than 1,600 environmental and diarrheal isolates in a previously collected database of PhP types of Bangladeshi Aeromonas isolates. The 52 Aeromonas isolates were investigated for the production of hemolysin and cytotoxin; for hemagglutination with erythrocytes from fish, human, and rabbit sources; for the presence of a cytolytic enterotoxin gene; and for adhesion to and invasion into fish cell lines. All of the EUS isolates produced all of the virulence factors investigated, as did also some of the environmental isolates, but the isolates from EUS were unique in their ability to agglutinate fish erythrocytes. Our results suggest that a clonal group of A. veronii biovar sobria is associated with, and may be a causative agent of, EUS in fish in Bangladesh.
Diffusion limitation effects in the washcoat of a catalytic monolith reactor (1996)

Abstract In monolith reactors with catalytic washcoat, intraphase diffusion effects have often been underestimated. This paper presents numerical simulations of diffusion/reaction in the washcoat of a catalytic monolith reactor. The problem is solved in two dimensions for the washcoat geometry obtained in a 1‐mm square monolith channel, as revealed by scanning electron microscopy. For the oxidation of carbon monoxide, propane or methane diffusion limitation can be substantial at typical operating conditions. The two‐dimensional solution is compared to a one‐dimensional approximation. The latter approximation for the real washcoat is valid provided that the characteristic length is selected carefully. This value is different from the characteristic length of the two‐dimensional washcoat. The characteristic length of a two‐dimensional geometry is not sufficient in itself to describe all washcoat geometries. It is predicted that the application of a diffusion barrier of 4–6 μm of inactive washcoat may be used to lower the rate of reaction in the inlet region of the monolith reactor.
Face Verification using MLP and SVM (2002)

The performance of machine learning algorithms has steadily improved over the past few years, such as MLP or more recently SVM. In this paper, we compare two successful discriminant machine learning algorithms apply to the problem of face verification: MLP and SVM. These two algorithms are tested on a benchmark database, namely XM2VTS. Results show that a MLP is better than a SVM on this particular task.
Proteomic Analysis of Ethene-Enriched Groundwater Microcosms from a Vinyl Chloride-Contaminated Site (2010)

Contamination of groundwater with vinyl chloride (VC), a known human carcinogen, is a common environmental problem at plastics manufacturing, dry cleaning, and military sites. At many sites, there is the potential to cleanup VC groundwater plumes with aerobic VC-oxidizing microorganisms (e.g., methanotrophs, etheneotrophs, and VC-assimilating bacteria). Environmental biotechnologies that reveal the presence and activity of VC-oxidizing bacteria in contaminated groundwater samples would provide valuable lines of evidence that bioremediation of VC is occurring at a site. We applied targeted shotgun mass spectrometry-based proteomic methods to ethene-enriched groundwater microcosms from a VC-contaminated site. Polypeptides from the enzymes alkene monooxygenase (EtnC) and epoxyalkane:CoM transferase (EtnE), both of which are expressed by aerobic etheneotrophs and VC-assimilating bacteria, were identified in 7 of the 14 samples analyzed. Bioinformatic analysis revealed that 2 EtnC and 5 EtnE peptides were unique to deduced EtnC and EtnE sequences from two different cultivated strains. In addition, several partial EtnE genes sequenced from microcosms matched with observed EtnE peptides. Our results have revealed broader etheneotroph functional gene diversity and demonstrate the feasibility, speed, and accuracy of applying a targeted metaproteomics approach to identifying protein biomarkers from etheneotrophs in complex environmental samples.
Eosinophilia and fluid retention in systemic administration of interleukin-2. (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.5.815 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3486257 Eosinophilia and fluid retention in systemic administration of interleukin-2. J S KovachxJ S KovachSearch for articles by this author , G J GleichxG J GleichSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.5.815 PDF "Eosinophilia and fluid retention in systemic administration of interleukin-2.." Journal of Clinical Oncology, 4(5), pp. 815–816© 1986 by American Society of Clinical Oncology
Rotavirus and biliary atresia (2011)

Rotavirus can be detected in the serum of mice and children and causes biliary atresia in neonatal mice. Approaches to re-examine whether rotavirus causes biliary atresia in children are discussed based on concepts from the mouse model of biliary atresia and rotavirus vaccination programs.
An Unusual Ditelluride: Synthesis and Molecular and Electronic Structures of the Dimer of the Tellurium‐Centered Radical [TeP<i>i</i>Pr<sub>2</sub>N<i>i</i>Pr<sub>2</sub>PTe]<sup>.</sup> (2005)

Mit der mühelosen Bildung des Ditellurids [(TePiPr2NiPr2PTe)2], das als zentrosymmetrisches Dimer (siehe Bild; Te grün, P violett, N blau, C grau) mit einer schwachen Te-Te-Bindung vorliegt, tritt eine neuartige Reaktivität in der Chemie der Dichalkogenoimidodiphosphinat-Liganden in Erscheinung. Das analoge Monotellurid HPiPr2NiPr2PTe wird in Form des P-H-Tautomers erhalten.
Parallel Processing for Real-Time Dynamic System Simulation (1990)

A parallel processing algorithm based on the recursive dynamics formulation presented in a companion paper [1] is developed for multiprocessor implementation. Lagrange multipliers associated with cut-joint constraints for closed loop systems are eliminated, resulting in a minimal set of equations of motion. Concurrent generation of the system inertia matrix and the generalized force vector using the algorithm of Ref. 1 is shown to yield finer grain parallelism than earlier recursive algorithms. A new computational structure for dynamic analysis is proposed for high speed parallel processing. Real-time simulation of a vehicle is demonstrated on an eight processor parallel computer to illustrate efficiency and effectiveness of the algorithm, even for interactive operator-in-the-loop simulation.
Mathematical Simulation of the Sorbent-Based Atmosphere Revitalization System for the Crew Exploration Vehicle (2006)

<div class="htmlview paragraph">A cyclic adsorption process simulator was used to determine preliminary bed size and characteristics for a sorbent-based atmosphere revitalization (SBAR) system being designed by NASA for the Crew Exploration Vehicle. An initial study of a 2-bed 3-step 3-layer, vacuum swing adsorption cycle, utilizing 50% silica gel, 17% 13X zeolite, and 33% 5A zeolite revealed that a 10 L bed could easily meet the CO<sub>2</sub> and H<sub>2</sub> O removal criteria for a 3 person crew. A parametric study showed that the cycle time, layering percentage of silica gel, and H<sub>2</sub> O-silica gel mass transfer coefficient were important parameters in the SBAR design. Increasing the cycle time diminished the CO<sub>2</sub> and H<sub>2</sub> O removal performances but resulted in less O<sub>2</sub> lost to space. The CO<sub>2</sub> and H<sub>2</sub> O removal performances increased considerably when a silica gel layer was added to the bed, with the above layering percentages being close to optimum. As more silica gel was added to the bed slightly more O<sub>2</sub> was lost. Larger values of the H<sub>2</sub> O-silica gel mass transfer coefficient improved the CO<sub>2</sub> and H<sub>2</sub> O removal performances but at the expense of slightly more O<sub>2</sub> lost.</div>
Role of the Aryl Hydrocarbon Receptor in Controlling Maintenance and Functional Programs of RORγt+ Innate Lymphoid Cells and Intraepithelial Lymphocytes (2012)

Mucosal retinoic receptor-related orphan receptor (ROR)γt-expressing innate lymphoid cells (ILC) play an important role in the defense against intestinal pathogens and in promoting epithelial homeostasis and adaptation, thereby effectively protecting the vertebrate host against intestinal inflammatory disorders. The functional activity of RORγt(+) ILC is under the control of environmental cues. However, the molecular sensors for such environmental signals are largely unknown. Recently, the aryl hydrocarbon receptor (AhR) has emerged as a master regulator for the postnatal maintenance of intestinal RORγt(+) ILC and intraepithelial lymphocytes. AhR is a highly conserved transcription factor whose activity is regulated by environmental and dietary small molecule ligands. Here, we review the role of AhR signaling for the maintenance of intestinal immune cells and its impact on the immunological protection against intestinal infections and debilitating chronic inflammatory disorders.
ChemInform Abstract: Immobilization of Penicillin G Acylase on Methacrylate Polymers. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Measurements of Flow Speeds in the Corona Between 2 and 30<i>R</i><sub>☉</sub> (1997)

Time-lapse sequences of white-light images, obtained during sunspot minimum conditions in 1996 by the Large Angle Spectrometric Coronagraph on the Solar and Heliospheric Observatory, give the impression of a continuous outflow of material in the streamer belt, as if we were observing Thomson scattering from inhomogeneities in the solar wind. Pursuing this idea, we have tracked the birth and outflow of 50-100 of the most prominent moving coronal features and find that:
Key Enantioselective Hydrogenation Steps in the Syntheses of Two Renin Inhibitors: Missing Origin and Incorrect Description (2012)

ADVERTISEMENT RETURN TO ISSUEPREVLetter to the EditorNEXTKey Enantioselective Hydrogenation Steps in the Syntheses of Two Renin Inhibitors: Missing Origin and Incorrect DescriptionValentin RautenstrauchView Author Information 60 rue de Creptiout, 74160 Collonges-sous-Salève, France[email protected]Cite this: Org. Process Res. Dev. 2012, 16, 6, 1185–1186Publication Date (Web):May 29, 2012Publication History Published online29 May 2012Published inissue 15 June 2012https://pubs.acs.org/doi/10.1021/op300121jhttps://doi.org/10.1021/op300121jletterACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views1365Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Catalytic reactions,Hydrogenation,Inhibitors,Ligands Get e-Alerts
Analysis of Nuclear Dna and Morphometry, and Proliferating Cell Nuclear Antigen in Primary and Metastatic Malignant Melanoma (1997)

Sections from 23 primary malignant melanomas and 39 corresponding metastases were analysed for DNA content, nuclear morphometry, and proliferating cell nuclear antigen (PCNA). In 15 of 23 patients (65%) both primary and secondary tumours showed similar DNA patterns, whereas a disparity was found in the remaining eight patients (35%). The 23 primary tumours and groups of metastases (from different patients) located in skin, lymph nodes, and brain did not differ significantly in any of the variables investigated. Cox stepwise regression analysis indicated that a large variability (CV) of nuclear area in the first metastasis correlated with increased survival after recurrence (p = 0.039) as well as with survival (p = 0.031).
Profile tracking performance of a low ripple hybrid stepping motor servo drive (2003)

A control strategy to harness the torque ripple of a hybrid stepping motor at low speeds for precision profile tracking is proposed. The strategy uses a model-based control design that controls the phase current based on the direct quadrature transformation of the second-order nonlinear dynamics. An identification procedure based on a least-squares algorithm is applied to estimate the model parameters for calculation of the ripple dynamics. The method produces a more appropriate form of linear regression which avoids the problem of reconstructing important signals such as the rotor speed and the derivatives of the driving current, and rejects additional errors created by the quantisation of the measurements. This paves the way for an integrative process to obtain precise trajectory tracking by combining a reference trajectory, traditional PID control, and dynamic feedback linearising control coupled with feedforward compensation over a broad torque-ripple frequency band. Simulations and experiments are performed with a typical hybrid stepping motor to test its profile tracking accuracy. The results may be used to develop a commercial control scheme for tuning computer-controlled drives.
THE PREPARATION OF SINGLE CRYSTALS OF CERTAIN TRANSITION METAL FLUORIDES (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE PREPARATION OF SINGLE CRYSTALS OF CERTAIN TRANSITION METAL FLUORIDESH. GuggenheimCite this: J. Phys. Chem. 1960, 64, 7, 938–939Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July 1960https://doi.org/10.1021/j100836a506RIGHTS & PERMISSIONSArticle Views125Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (304 KB) Get e-Alerts
A review of treatment for carpal tunnel syndrome (2003)

This article provides a background in current treatment methods and an insight into the focal point of the future.
Tunable Visible Light Emission of Self-Assembled Rhomboidal Metallacycles (2013)

Supramolecular coordination complexes (SCCs) have been proposed for applications necessitating photon emitting properties; however, two critical characteristics, facile tunability and high emission quantum yields, have yet to be demonstrated on SCC platforms. Herein, a series of functionalized D2h [D2A2] rhomboids (D = 2,6-bis(4-ethynylpyridine)aniline-based ligands; A = 2,9-bis[trans-Pt(PEt3)2NO3]phenanthrene) is described with emission wavelengths spanning the visible region (λmax = 476-581 nm). Tuning was achieved by simple functional group modifications para to the aniline amine on the donor building block. Steady-state absorption and emission profiles were obtained for each system and are discussed. When the Hammett σ(para) constants for the functional groups para to the aniline amine were plotted versus the wavenumber (cm(-1)) for the λmax of the emission profile, a linear relationship was observed. By utilizing this relationship, the emission wavelength of a given rhomboid can be predetermined on the basis of the Hammett constant of the functionality employed on the donor precursor. This range of visible light emission for a suite of simple rhomboids along with the predictive nature of the wavelength of emission is unprecedented for these types of systems.
The Influence of DNA Methyl Transferase Inhibition in a Rat Model of Pressure-Overload Cardiac Hypertrophy (2015)

Objectives: Epigenetic regulation comprises histone acetylation, histone methylation and DNA methylation. We have recently observed dynamic changes in DNA methylation in an in vitro model of cardiac hypertrophy, which were associated with the stereotypic transcriptional and functional characteristics of pathological cardiac hypertrophy. The associated impairment of cardiomyocyte function could be attenuated by the DNA methyl transferase (DNMT) inhibitor RG108, suggesting that increases in DNA methylation take part in the pathogenesis of cardiac hypertrophy. This study aimed at evaluating effects of RG108 in an in vivo model of cardiac hypertrophy in rats.
Planar laser-induced-fluorescence imaging measurements of OH and hydrocarbon fuel fragments in high-pressure spray-flame combustion (1995)

Planar laser-induced fluorescence images of OH have been obtained in liquid-fueled spray flames burning heptane, ethanol, and methanol over a range of pressures from 0.1 to 1.0 MPa. In addition to the OH fluorescence, a nonresonant fluorescence interference that increased rapidly with pressure was detected. Examination of the spectrum of this interference indicates that it arises from hydrocarbon fuel-fragment species in the fuel-rich zones of the flame. The pressure dependence of the fluorescence signal is examined in both steady-state and time-dependent analyses, and a model for evaluation of pressure effects and quenching variations in quantitative imaging measurements in nonpremixed flame environments is presented. The results indicate that increased combustor pressure results in a rapid rise of the volume fraction of hydrocarbon fragments and a decrease in the OH volume fraction.
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory (2014)

Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system. We used a genetic approach to evaluate the role of the molecular clock in memory. Bmal1-/- mice, which are arrhythmic under constant conditions, were examined for hippocampus-dependent memory, LTP at the Schaffer-collateral synapse, and signal transduction activity in the hippocampus. Bmal1-/- mice exhibit impaired contextual fear and spatial memory. Furthermore, LTP in hippocampal slices from Bmal1-/- mice is also significantly decreased relative to that from wild-type mice. Activation of Erk1,2 MAP kinase (MAPK) during training for contextual fear memory and diurnal oscillation of MAPK activity and cAMP in the hippocampus is also lost in Bmal1-/- mice, suggesting that the memory defects are due to reduction of the memory consolidation pathway in the hippocampus. We conclude that critical signaling events in the hippocampus required for memory depend on BMAL1.
Accumulation of α-Tocopherol in Senescing Organs as Related to Chlorophyll Degradation (1989)

alpha-Tocopherol (alpha-T) has been identified, using gas chromatography-mass spectroscopy and (1)H- and (13)C-nuclear magnetic resonance, in senescing leaves of Melia azedarach L. The content of alpha-T increased concomitantly with the breakdown of chlorophyll in senescing Vinca and Melia leaves. An increase in alpha-T was found also in detached Melia leaves, senescing in either light or darkness and in senescing, ethylene-treated orange leaves and fruit. The possibility that phytol, which is released from chlorophyll by chlorophyllase is utilized for the biosynthesis of alpha-T is discussed. Senescing leaves of the low chlorophyllase plants, parsley and tobacco, did not contain alpha-T in measureable amounts.
Report on 2013 C&E Spring Meeting in Leuven, Belgium – Unlocking the Full Potential of Cereals: Challenges for Science Based Innovation (2013)

status: Published
DNA Interstrand Cross-links of the Novel Antitumor Trinuclear Platinum Complex BBR3464 (2002)

The novel phase II antitumor polynuclear platinum drug BBR3464 ([(trans-PtCl(NH(3))(2))(2)(mu-trans-Pt(NH(3))(2)(NH(2)(CH(2))(6)NH(2))(2))](NO(3))(4)) forms intra- and interstrand cross-links (CLs) on DNA (which is the pharmacological target of platinum drugs). We examined first in our recent work how various intrastrand CLs of BBR3464 affect the conformation of DNA and its recognition by cellular components (Zehnulova, J., Kasparkova, J., Farrell, N., and Brabec, V. (2001) J. Biol. Chem. 276, 22191-22199). In the present work, we have extended the studies on the DNA interstrand CLs of this drug. The results have revealed that the interstrand CLs are preferentially formed between guanine residues separated by 2 base pairs in both the 3' --> 3' and 5' --> 5' directions. The major 1,4-interstrand CLs distort DNA, inducing a directional bending of the helix axis and local unwinding of the duplex. Although such distortions represent a potential structural motif for recognition by high mobility group proteins, these proteins do not recognize 1,4-interstrand CLs of BBR3464. On the other hand, in contrast to intrastrand adducts of BBR3464, 1,4-interstrand CLs are not removed from DNA by nucleotide excision repair. It has been suggested that interstrand CLs of BBR3464 could persist considerably longer in cells compared with intrastrand adducts, which would potentiate the toxicity of the interstrand lesions to tumors sensitive to this polynuclear drug.