gebhart/patrepeval huggingface dataset:
Abstract 5767: Viral Anti-inflammatory Treatment of Unstable Coronary Syndromes: The VT-111 Acute Coronary Syndrome Trial (2009)

Background: Up-regulation of inflammatory responses contributes to coronary plaque rupture, thrombosis, and vascular occlusion leading to myocardial and cerebral infarction. Some viruses have developed potent proteins that block key steps in both the innate and adaptive immune responses. VT-111 is a viral serine proteinase inhibitor that demonstrates reductions in monocyte migration to sites of vascular damage in a wide range of animal models. Methods: In a double-blind, placebo-controlled trial, the safety of VT-111 plus standard of care was evaluated in patients with acute coronary syndromes treated with stents. Patients received IV VT-111 or placebo once daily for 3 days, starting immediately before intervention. Patients were followed for 3 days in hospital, and at 14, 28 days and 3 and 6 months for safety/efficacy endpoints, including biomarker analysis and MACE (death, MI or revascularization). At 6 months, restenosis was evaluated by intravascular ultrasound. Results: Forty-eight patients were enrolled at 7 sites; 19 patients received 5 μ g/kg VT-111, 17 patients received 15 μ g/kg and 12 patients received placebo. There were no differences between the treated and control groups on key safety endpoints, including coagulation parameters and adverse events. A trend towards a decrease in MACE was observed, with a reduction to 0% in the 15 μ g/kg group from 18% in controls. A significant, dose-dependent reduction in Troponin I levels was observed with VT-111 at 8, 16, 24 and 54 hours post-dose (p<0.05). Similar reductions were observed in CK-MB levels at 8, 16 and 24 hours post-dose (p<0.05). Trends towards a reduction in MCP-1 were also observed. Further analysis suggests that VT-111 may also have early effects on markers such as EN-RAGE (S100A12), IL-6 and CD40L. There were no differences in in-stent plaque area or lumen area between control and treated groups, as assessed by IVUS. Conclusion: This randomized, placebo-controlled trial supports the safety of 3 daily IV injections of VT-111, a first in class viral-derived anti-inflammatory therapeutic agent. A significant reduction in biomarkers of cardiac damage demonstrates the potential of this novel class of protein therapeutics.
APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons. (1996)

The Drosophila Appl gene encodes a transmembrane protein that is expressed exclusively in neurons. Amino acid comparisons show that APPL protein is a member of the amyloid precursor protein (APP)-like family of proteins. Similar to mammalian APP-family proteins, APPL is synthesized as a transmembrane holoprotein and cleaved to release a large secreted amino-terminal domain. Using immunocytochemical methods, we have analyzed the distribution of APPL in the Drosophila CNS. Surprisingly, although APPL is present in all neuronal cell bodies, the neuropil shows stereotypic differential distribution. Double-labeling experiments with different neuronal markers were used to distinguish between APPL associated with neuronal processes or extracellular matrix. The distribution of APPL protein produced from transgenes encoding wild-type (APPL), secretion-defective (APPL(sd)), and constitutively secreted (APPL(s)) forms was analyzed in an Appl-deficient background to determine which APPL form is associated with different neuropil regions. We found that APPL(sd) protein is enriched where APPL immunoreactivity coincides with neuronal processes. In contrast, APPL(s) preferentially localizes to those parts of the neuropil that show a diffuse APPL signal that rarely colocalizes with processes, and thus seems to be a component of the extracellular matrix. These data indicate that proteolytic cleavage and trafficking of APPL is differentially regulated in different neuronal populations. Through metamorphosis, APPL is especially abundant in growing axons and in areas where synapses are forming. Interestingly, in adult brains, APPL protein is enriched in the mushroom bodies and to a lesser extent in the central complex, structures involved in learning and memory.
Correction: FoxO3a Modulates Hypoxia Stress Induced Oxidative Stress and Apoptosis in Cardiac Microvascular Endothelial Cells (2013)

Cardiac microvascular endothelial cells (CMECs) dysfunction induced by hypoxia is an important pathophysiological event in myocardium ischemic injury, whereas, the underlying mechanism is not fully clarified. FoxO transcription factors regulate target genes involved in apoptosis and cellular reactive oxygen species (ROS) production. Therefore, the present study was designed to elucidate the potential role of FoxOs on the hypoxia-induced ROS formation and apoptosis in CMECs. Exposure to low oxygen tension stimulated ROS accumulation and increased apoptosis in CMECs within 6-24 h. Hypoxia also significantly increased the expressions of HIF-1a and FoxO3a. However, hypoxia decreased the phosphorylation of Akt and FoxO3a, correlated with increased nuclear accumulation. Conversely, the expression of FoxO1 was not significantly altered by hypoxia. After inhibition of HIF-1a by siRNA, we observed that hypoxia-induced ROS accumulation and apoptosis of CMECs were decreased. Meanwhile, knockdown of HIF-1a also inhibited hypoxia induced FoxO3a expression in CMECs, but did not affect FoxO1 expression. Furthermore, hypoxia-induced ROS formation and apoptosis in CMECs were correlated with the disturbance of Bcl-2 family proteins, which were abolished by FoxO3a silencing with siRNA. In conclusion, our data provide evidence that FoxO3a leads to ROS accumulation in CMECs, and in parallel, induces the disturbance of Bcl-2 family proteins which results in apoptosis.
The presented past: heritage, museums and education.: Peter G. Stone y Brian Molyneaux (Eds.) (1994): The Presented Past: Heritage, Museums and Education. Londres: Routledge. (2009)

El libro resenado es una reunion de investigaciones que tienen por tematica central la
relacion entre el patrimonio y la educacion, y que fueron presentadas con motivo del
Segundo Congreso Internacional de Arqueologia, celebrado en Venezuela en 1990.
Esta obra supone un hito historico en la configuracion de la disciplina de la Educacion
Patrimonial, por cuanto consiguio reunir un buen numero de contribuciones sobre esta
tematica tan novedosa a pricipios de los noventa del pasado siglo. Como se indica, la
compilacion de articulos se encuadro dentro del Segundo Congreso Internacional de
Arqueologia. En su vertiente anglosajona, la Arqueologia se ha significado como una de
las disciplinas pioneras en el estudio de la Educacion Patrimonial. Sin embargo, puede
decirse que esta compilacion trasciende los limites de la arqueologia, y se constituye en
una obra de referencia dentro de las Ciencias Sociales.
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice <i>in vivo</i> (2006)

Muscle injury or modified muscle use can stimulate muscle invasion by leucocytes that have the potential to increase tissue damage or promote tissue growth and repair. In the present investigation, we examined the role of macrophages in muscle injury, repair and regeneration during modified muscle loading. Weight-bearing was removed from the hindlimbs of mice for 10 days followed by reloading through normal ambulation. During the unloading period, soleus muscle fibre cross-section decreased by 38%. Prior to the onset of reloading, mice received a series of intraperitoneal injections of anti-F4/80, which binds a mouse macrophage surface antigen. Although anti-F4/80 injections did not affect macrophage numbers in soleus muscles at 2 days of reloading, macrophages were reduced by 86% at 4 days of reloading. Muscle membrane lysis during the reloading period did not differ at 2 days of reloading between anti-F4/80-treated mice and mice that received isotype control antibody. However, control animals showed large decreases in the number of fibres with membrane lesions at 4 days of reloading, but this membrane repair did not occur in macrophage-depleted mice. Macrophage-depletion also reduced muscle regeneration (indicated by central nucleation) and satellite cell differentiation (indicated by reductions in MyoD-expressing satellite cells) and prevented growth of muscle fibres that normally occurred in control animals between days 2 and 4 of reloading. These findings collectively show that macrophages play a significant role in muscle fibre membrane repair, regeneration and growth during increased muscle use after a period of atrophy.
Ablation of osteoid osteomas with a percutaneously placed electrode: a new procedure. (1992)

Osteoid osteoma is a benign, self-limited tumor of bone that usually requires surgical excision for relief of pain and to prevent long-term consequences. Radio-frequency electrodes have been successfully and safely used to ablate small areas of the central nervous system and to perform ablation elsewhere in the body. The authors have used this technique in four patients with proved or presumptive osteoid osteoma, completely relieving the symptoms in three.
Reciprocal Interactions Between Calcium and Chloride in Rod Photoreceptors (2003)

This study used imaging and electrophysiological techniques in salamander retinal slices to correlate Ca2+ and Cl- levels in rods and thus test the hypothesis of a feedback interaction between Ca2+- and Ca2+-activated Cl- channels whereby Cl- efflux through Cl- channels can inhibit Ca2+ channels. Increasing [K+]o levels produced a concentration-dependent depolarization of rods accompanied by increases in [Ca2+]i measured with Fura-2. The voltage dependence of increases in [Ca2+]i was compared with the voltage dependence of the calcium current (ICa). [Cl-]i was measured with the dye, MEQ. Depolarization with high K+ to membrane potentials below -20 mV reduced [Cl-]i; larger depolarizations increased [Cl-]i. The Na/K/Cl cotransport inhibitor, bumetanide, shifted the apparent Cl- equilibrium potential (ECl) to more negative potentials, suggesting that this cotransporter helps establish a relatively depolarized ECl. MEQ fluorescence changes evoked by high K+ were inhibited by niflumic acid (0.1 mM), NPPB (2 microM), or replacement of Ca2+ with Ba2+, suggesting that depolarization-evoked Cl- changes result partly from stimulation of Ca2+-activated Cl- channels. Replacing >/=12 mM [Cl-]o with CH3SO4- produced a significant reduction in [Cl-]i. [Ca2+]i increases evoked by 20 or 50 mM K+ were also significantly inhibited by replacing >/=12 mM [Cl-]o with CH3SO4-. Thus modest depolarization can evoke increases in [Ca2+]i that lead to reductions in [Cl-]i, and conversely, reductions in [Cl-]i inhibit depolarization-evoked [Ca2+]i increases. These findings support the hypothesis that feedback interactions between Ca2+- and Ca2+-activated Cl- channels may contribute to the regulation of presynaptic Ca2+ currents involved in synaptic transmission from rod photoreceptors.
Visual estimation of pointed targets for robot guidance via fusion of face pose and hand orientation (2011)

In this paper we address an important issue in human-robot interaction, that of accurately deriving pointing information from a corresponding gesture. Based on the fact that in most applications it is the pointed object rather than the actual pointing direction which is important, we formulate a novel approach which takes into account prior information about the location of possible pointing targets. To decide about the pointed object, the proposed approach uses the Dempster-Shafer theory of evidence to fuse information from two different input streams: head pose, estimated by visually tracking the off-plane rotations of the face, and hand pointing orientation. Detailed experimental results are presented that validate the effectiveness of the method in realistic application setups.
A Distinct Expression of Various Gene Subsets in CD34+ Cells Obtained From Patients with Early and Advanced Myelodysplastic Syndrome. (2009)

Abstract Abstract 3795 Poster Board III-731 Gene expression profiles of CD34+ cells were compared between a cohort of 51 patients with MDS or AML from MDS and 7 healthy controls. The patients were classified according to the WHO criteria as follows: 5q- syndrome (n=7), RA (n=3), RARS (n=2), RCMD (n=10), RAEB-1 (n=7), RAEB-2 (n=15), and AML with MLD (multilineage dysplasia) (n=7). HumanRef-8 v2 Expression Bead Chips (Illumina) were used to generate expression profiles of the samples for >22,000 transcripts. The raw data were normalized data with the R software, lumi package. Normalized data were filtered by detection p-value <0.01, resulting in total number of 9811genes. To identify differentially expressed genes we performed two parallel statistical hypothesis testings: Analysis of Variance (ANOVA) together with Tukey test and empirical bayesian thresholding correction for multiple testing problem; and Significance Analysis of Microarrays (SAM). The results were confirmed by real-time quantitative PCR for six genes (TaqMan Gene Expression Assays). Hierarchical clustering of significantly differentially expressed genes clearly separated patients and controls, 5q-syndrome and RAEB-1 as a separate entities confirming usefulness of WHO classification subgroups. The most up-regulated genes in all patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT1, and MYC. We assume that expression changes in globin genes, both fetal and adult globins (HBG2, HBG1 and HBA1, HBB) may play role not only in dysregulation of erythropoiesis but also in the disease progression or leukemic transformation of MDS. Among the most down-regulated genes, 13 genes related to B-lymphopoiesis (e.g. POU2AF1, VPREB1, VPREB3, CD79A, EBF1, LEF1, BCL3, IRF8 & IRF4) were detected, suggesting the abnormal development of B-cell progenitors in all MDS patients. Some of these genes (e.g. VPREB3, LEF1) showed decreasing trend in expression level from early to advanced MDS with the lowest expression in AML with MLD. Patients with advanced MDS had significantly decreased expression of genes involved in in the mitotic cell cycle, DNA replication, and chromosome segregation compared to early MDS where these gene subsets were up-regulated. The DAVID database also identified de-regulation in the cell cycle pathway through its 7 genes (CDC25C, CDC7, CDC20, ORC1L, CCNB2, BUB1, & CCNA2). On the other hand, advanced MDS patients showed significant up-regulation of proto-oncogenes (BMI1, MERTK) and genes related to angiogenesis (ANGPT1), anti-apoptosis (VNN1). The results confirm on molecular basis that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in the expansion of malignant clone in MDS patients. The study was supported by Grant NR-9235 obtained from the Ministry of Health, Czech Republic. Disclosures: No relevant conflicts of interest to declare.
Improved Ultraviolet Microbeam Apparatus (1957)

An ultraviolet microbeam apparatus utilizing the principle of incident illumination has been developed for the irradiation of small parts of living cells or other microscopic objects. A reflecting microscope objective is used simultaneously in a visible light viewing-aiming system and in a bombardment system to focus a spot of ultraviolet light (as small as one micron in diameter) onto part of an experimental preparation. Provision is made in the apparatus for auxiliary phase contrast viewing and for monitoring of the energy in the microbeam. Details of construction and alignment are given and the distribution of intensities in the microbeam is discussed.
Mechanism Design for Near Real-Time Retail Payment and Settlement Systems (2015)

Rapid expansion of e-commerce, along with rising domestic and cross-border payments, has fueled the demand among financial institutions for cost-effective means to achieve real-time settlement of retail payments. Traditionally, retail payments have made extensive use of interbank netting systems, in which payments are accumulated for end-of-day settlement. This approach, known as deferred net settlement (DNS), reduces the liquidity needs of a payment system, but bears inherent operational risks. As large dollar volumes of retail payments accumulate swiftly, real-time gross settlement (RTGS) is an attractive option. It permits immediate settlement of transactions during the day, but it brings up other risks that require consideration. We propose a hybrid payment management system involving elements of both DNS and RTGS. We explore several hybrid system mechanism designs to allow payment prioritization, reduce payment delays, enhance liquidity by pooling payments from banks, and optimize settlement. We provide a modeling framework and experimental set-up to evaluate the proposed approach. Our results shed new light about cost-effective and value-maximizing mechanisms to quickly settle increasingly large volumes of retail payments.
(Invited) The Role of Oxygen in the Development of Hf-Base High-k/Metal Gate Stacks for CMOS Technologies (2010)

The threshold voltage in HfO2/metal gated FETs is found to strongly dependent on the annealing conditions used for device fabrication. It is shown that this dependence arises in a large part from the formation of positively charged oxygen vacancy in the HfO2 layer during high temperature process steps. At low temperatures, oxygen stored in the metal gate or residual oxygen in the ambient of processing tools can diffuse back into the HfO2 layer, having a profound effect on the threshold voltage by modulating the concentration of charged defects. In absence of any oxygen sources, the threshold voltage is dictated by the temperature alone suggesting a thermal equilibrium between the vacancy concentration in the HfO2 layer and Si or metal oxidation. The extreme sensitivity of Vt to the external oxygen pressure can be used to tune the threshold voltage of pFET devices in advanced CMOS technologies.
In Vitro Selection and Characterization of TCF-1 Binding RNA Aptamers (2004)

TCF proteins are architectural transcription factors that bind to beta-catenin when the Wnt signaling pathway is activated. TCF-1 is specifically expressed in T-cell lineages and its interaction with beta-catenin is thought to be critical for early T-cell development. However, the mechanisms underlying activation of TCF-1 during T-cell development are not completely understood. With the aim of developing RNA aptamers that bind to TCF-1 and regulate its activity, we screened an RNA library consisting of random sequences of 70 nucleotides and were able to isolate aptamers that bind to TCF-1 with high affinity and specificity. We employed RNase footprinting to characterize the RNA structures and map their binding sites for TCF-1. It is hoped that the selected aptamers will regulate TCF-1 activity in vivo, thereby providing a unique tool for modulating TCF-1 function in early T-cell development.
Water inventories on Earth and Mars: Clues to atmosphere formation (1992)

Water is distributed differently on Earth and on Mars and the differences may have implications for the accretion of the two planets and the formation of their atmospheres. The Earth's mantle appears to contain at least several times the water content of the Martian mantle even accounting for differences in plate tectonics. One explanation is that the Earth's surface melted during accretion, as a result of development of a steam atmosphere, thereby allowing impact-devolitalized water at the surface to dissolve into the Earth's interior. In contrast, because of Mars' smaller size and greater distance from the Sun, the Martian surface may not have melted, so that the devolatilized water could not dissolve into the surface. A second possibility is suggested by the siderophile elements in the Earth's mantle, which indicates the Earth acquired a volatile-rich veneer after the core formed. Mars may have acquired a late volatile-rich veneer, but it did not get folded into the interior as with the Earth, but instead remained as a water rich veneer. This perception of Mars with a wet surface but dry interior is consistent with our knowledge of Mars' geologic history.
High-efficiency beam bending using graded photonic crystals (2013)

We explore beam-bending properties of graded index (GRIN) waveguide with hyperbolic secant profile. The transmission efficiency and bandwidth features are extracted for GRIN photonic crystal (PC) media composed of dielectric rods. Light guiding performance of the GRIN PC medium is analyzed for 90° and 180° waveguide bends. The finite-difference time-domain method is deployed to investigate the performance of the designed GRIN waveguides. By the help of proposed photonic configuration, bending of light is achieved with a high efficiency within a broad bandwidth, which promotes the use of GRIN PC structures for efficient light-bending purposes.
The Control of Gastrointestinal Hemorrhage by Selective Mesenteric Arterial Infusion of Vasopressin (1971)

Of 48 patients given selective mesenteric arterial infusion of vasopressin for the control of gastrointestinal hemorrhage, 28 were actively bleeding from varices secondary to portal hypertension, 14 were infused electively at the time of portosystemic shunt surgery, and 6 were infused because of hemorrhage from an arterial or capillary source demonstrated on prior selective arteriography. The indications, technique, and results of the vasopressin infusions are described.
A deep learning based video classification system using multimodality correlation approach (2017)

In this paper, we propose a video event classification system that classifies video events using the correlation of images and sounds extracted from one video. The proposed system has better classification performance than other systems using single modality.
Internet Information Services Administration (2000)

Administrators who know IIS from previous versions need this book to show them in concrete detail how to configure the new protocols, authenticate users with the new Certificate Server, and implement and manage the new e-commerce features. You want to know how to work with the MMC, so that you'll be ready for Windows NT 5.0. This book gives you all of that: a quick read that provides real world solutions, and doubles as a portable reference. Although IIS has been available for several years now, version 4.0 of the Internet Information Server marks a major change in Microsoft's approach to Enterprise Web Service. The brand new feature set in IIS 4.0 reads like a wish list of hot Internet technologies. Administration of IIS has been overhauled by the integration of the Microsoft Management Console and is the first product to use MMC.
Inhibitory effects of urine on the polymerase chain reaction for cytomegalovirus DNA. (1991)

The inhibitory effects of urine samples taken from neonates and older children, some of which were known to be infected with cytomegalovirus, on the polymerase chain reaction (PCR) were investigated. Urea was the major inhibitory component of urine and inhibited the PCR at a concentration of more than 50 mM. Urine samples from older children were more inhibitory than those from neonates. This correlated with the higher concentration of urea generally found in urine samples from older children compared with neonatal urines. Two of 13 neonatal urine samples, however, were inhibitory despite low urea concentrations--presumably due to metabolites derived from parenteral nutrition. The inhibitory effects of urine were effectively removed by simple dialysis or ultrafiltration. The sensitivity and specificity of PCR for detecting cytomegalovirus DNA in urine were further improved by using "nested" primers and a modified PCR protocol entailing the use of reduced reactants in the first 20 cycles of a two-stage 50 cycle PCR.