gebhart/patrepeval huggingface dataset:
The mannose receptor is expressed by subsets of APC in non-lymphoid organs (2005)

The tissue and subcellular distribution of MR suggest it is appropriately located to serve as a high efficiency antigen uptake receptor of APC.
Comparative Analysis of TCR-γ Gene Rearrangements by Genescan and Polyacrylamide Gel-electrophoresis in Cutaneous T-cell Lymphoma (2003)

Demonstrating T-cell clonality has become an important approach supporting a diagnosis of malignant T-cell neoplasms. A comparative study between Genescan analysis, polyacrylamide gel and agarose gel electrophoresis in visualizing T-cell receptor gamma gene rearrangement was performed on 25 biopsy specimens from 18 patients with different forms of cutaneous T-cell lymphomas. Clonality was detected in 17 biopsy specimens when PCR products were evaluated by Genescan analysis. Seventeen showed discrete bands when visualized in polyacrylamide gel and 14 cases were clonal when visualized with agarose gel. In five cases, a clonal population was seen in the gels, but not with Genescan. On sequencing the PCR products we demonstrated non-clonality of these five samples. Our results confirm that PCR-Genescan is a useful, reliable and specific screening method for detecting dominant clones in patients with T-cell lymphoma.
Investigation of Charge-Transfer Interaction in Mixed Stack Donor–Acceptor Cocrystals Toward Tunable Solid-State Emission Characteristics (2018)

The formation of three mixed binary charge transfer (CT) cocrystals with tunable photoluminescence behavior featuring both CT interaction and directional hydrogen bonding is presented. Our strategy consists of the CT induced cocrystallization of three polycyclic (naphthalene, anthracene, and pyrene) carrying α-cyanostilbene (CS) derivatives, namely, 3-(naphthalene-2-yl)-2-(p-tolyl) acrylonitrile (NPA), 3-(anthracene-9-yl)-2-phenylacrylonitrile (APA), and 2-(4-methoxyphenyl)-3-(pyrene-1-yl) acrylonitrile (MPA) as donors (D) with 1,2,4,5-tetracyanobenzene (TCNB) as an acceptor (A). The as-prepared cocrystals were probed in detail by various analytical techniques, namely, X-ray diffraction data, vibrational spectroscopy, diffuse reflectance absorption spectroscopy, fluorescence properties, and fluorescence quantum yields and lifetimes, affirming the formation of CT complexes. Complex IA features a mixed stack arrangement (D–A–D–A–D), while IIA and IIIA revealed (DAD---DAD) stack arrangement. The CT products showed distinct tunable emission colors and photoluminescence characteristics, which is closely associated with the CT interactions between the donor and acceptor moiety, and ionization potential or the π-electron rich character of the polycyclic moiety of the donor molecule. This research demonstrates the development of new hybrid CT functional materials with enhanced optical properties such as absorption, fluorescence emissions, and lifetimes compared to the pristine donors, which is important for the exploration of new solid-state luminescent materials.
Can the state of platinum species be unambiguously determined by the stretching frequency of an adsorbed CO probe molecule? (2016)

The paper addresses possible ambiguities in the determination of the state of platinum species by the stretching frequency of a CO probe, which is a common technique for characterization of platinum-containing catalytic systems. We present a comprehensive comparison of the available experimental data with our theoretical modeling (density functional) results of pertinent systems - platinum surfaces, nanoparticles and clusters as well as reduced or oxidized platinum moieties on a ceria support. Our results for CO adsorbed on-top on metallic Pt(0), with C-O vibrational frequencies in the region 2018-2077 cm(-1), suggest that a decrease of the coordination number of the platinum atom, to which CO is bound, by one lowers the CO frequency by about 7 cm(-1). This trend corroborates the Kappers-van der Maas correlation derived from the analysis of the experimental stretching frequency of CO adsorbed on platinum-containing samples on different supports. We also analyzed the effect of the charge of platinum species on the CO frequency. Based on the calculated vibrational frequencies of CO in various model systems, we concluded that the actual state of the platinum species may be mistaken based only on the measured value of the C-O vibrational frequency due to overlapping regions of frequencies corresponding to different types of species. In order to identify the actual state of platinum species one has to combine this powerful technique with other approaches.
A member of the Hsp60 gene family from the peach potato aphid, <i>Myzus persicae</i> (Sulzer.) (2000)

A novel cDNA clone encoding a mitochondrial Hsp60 was isolated from a Myzus persicae cDNA library. The nucleotide sequence consisted of 2348 bp and contained an open reading frame (ORF) of 1722 bases. The putative protein encoded by this ORF consisted of 574 amino acids and was designated MPHSP60. Comparison of MPHSP60 with other Hsp60s found that it was most similar to Hsp60 from Culicoides variipennis (85.6% similarity). Phylogenetic analysis revealed that MPHSP60 is clustered together with other insect Hsp60s. Comparisons were also made between MPHSP60 and SymL, the GroEL homologue of Myzus persicae endosymbionts.
The Relationship between Body Composition and Sexual Satisfaction in Heterosexual, Caucasian Young Adults (2011)

Background: Sexual satisfaction is a multidimensional construct encompassing the positive and negative aspects of a sexual relationship and is influenced by many factors. Objectives: To investigate the relationship between body composition (weight (kg), total fat (kg, %) and trunk fat (kg, %)) and sexual satisfaction in young adults while controlling for age, body image, relationship satisfaction, sexual function and sexual frequency. Methods: A cross-sectional sample of 157 young adults completed a series of questionnaires and underwent body composition testing (DXA). Stepwise logistic regression models were tested. Results: For both women and men, trunk fat (kg) but no other body composition variable predicted sexual satisfaction. For women, sexual function had the greatest impact followed by relationship satisfaction, trunk fat (kg) and sexual frequency. For men, relationship satisfaction had the greatest impact followed by sexual frequency, age and trunk fat (kg). Conclusions: Other variables better predict sexual satisfaction than body composition.
Illustrating the process of ontology concept formulation in a multi-perspective social setting (2012)

The object of this grounded theory study was a three year long, public sector inter-organizational information system (IOIS) project which spanned four user organizations, two suppliers, one national organization, a research organization and a Government Ministry. The data were elicited by means of narrative stories, observations of project meetings, diaries, project memoranda and emails sent by project members to each other during these years. Glaserian grounded theory method was used as the technique for theory building. Three core categories were identified: governance, power and emotions. The study offers two key contributions: first, it builds a substantive theory of Emotions of Control in an IOIS project, presented in the form of propositions. The theory offers an approach to understanding the meaning of emotions in project work and the consequences of emotions in collaboration. Second, we offer a window into the theory building process using Glaserian grounded theory. We argue that the findings of this study have some implications of value to researchers studying emotional issues in IOIS projects or information system (IS) projects in general, because the role of emotions in project work can be pivotal in determining project success.
Simple Analgesics for Arthritis (1974)

A series of experiments has been carried out with single doses of simple analgesics in patients with rheumatoid arthritis using a consistent polyad design. This method proved to be both valid and useful. Pain relief scores were a better measure of the effectiveness of analgesics than preference.Aspirin, Codis, and Distalgesic were the most effective analgesics tested, with paracetamol, pentazocine, and Ciba 44,328 intermediate between these agents and placebo. Placebo given after an active analgesic was more effective than when given before; this phenomenon was not abolished by telling the patients that apparently identical tablets were, in fact, different or by making them different in colour. The effectiveness of soluble placebo depended on its colour, red being the most effective.
Aperture Couplings in Multilayer Filtering Structures (2007)

In multilayer structures apertures in metallic sheets can be used as coupling elements between resonators located on different layers, allowing very compact filter designs. In this paper, some novel types of planar microwave bandpass filters, using aperture couplings, in structures with three metallic layers, are considered. Couplings between two miniaturized resonators are investigated, by full electromagnetic field simulation. Based on the results of this study, several models of planar microwave bandpass filters, with a single or with two apertures, are designed, verified by simulation, fabricated and measured. Compared to the classical filters, these novel structures show a good compactness and can offer some technological advantages.
Color moiré pattern simulation and analysis in three-dimensional integral imaging for finding the moiré-reduced tilted angle of a lens array (2009)

We propose a color moiré pattern simulation and analysis method in integral imaging for finding the moiré-reducing tilted angle of a lens array. According to the tilted angle, the color moiré patterns are simulated on the assumption of ray optics. The spatial frequencies of the color moiré patterns are numerically analyzed using a spatial Fourier transform for finding the optimal angle where the moiré is reduced. With the proposed technique the visualization of the color moiré pattern and its analysis are enabled. The moiré-reduced three-dimensional images can be displayed. The principle of the proposed method, simulation results, and their analysis are provided. Experimental results verify the validity of the proposed method.
Design and optimization of an intumescent flame retardant coating using thermal degradation kinetics and Taguchi's experimental design (2012)

Abstract Two supplementary approaches in terms of thermal degradation kinetics and Taguchi's experimental design were employed toward developing a design effort for intumescent coatings. A model intumescent system including ammonium polyphosphate (APP), pentaerythritol (PER), melamine (MEL), thermoplastic acrylic resin and liquid hydrocarbon resin was chosen and then subjected to thermogravimetric analysis and heat insulation tests to provide experimental data. Kinetic analysis of the thermogravimetric data based on the Friedman and Kissinger methods revealed that activation energy ( E a ) and reaction order ( n ) could be used as parameters to accurately judge whether the selected intumescent components represented coordinated thermal characteristics. Examination of the calculated E a and n values showed that the decomposition of thermoplastic acrylic resin and liquid hydrocarbon resin occurred first and that the APP, PER and MEL components were degraded immediately after. Such a degradation sequence was quite consistent with the functional mechanism of intumescent systems. In addition, simultaneous implementation of analysis of variance and mean effect assessment on the Taguchi data demonstrated that the designed formulation, based on the optimized coupling of 10 g MEL into APP/PER 25 g/11 g, exhibited the highest fireproofing time among the prepared coating samples. The APP content had the most important contribution to the flame retardant behaviour, and APP versus PER interactions showed the highest severity index. Scanning electron microscopy showed that the higher flame retardancy of the optimized sample was related to the presence of a large number of micropores in the expanded charring layer structure. Copyright © 2012 Society of Chemical Industry
Development of capillary electrophoresis and mass spectrometry methods in protein analysis. (1999)

Capillary electrophoresis combined with mass spectrometric analysis has been applied to protein analysis at low-femtomole levels. An on-line CE/MS system has been developed with the use of the ion trap/reflectron time-of-flight mass spectrometer (IT/reTOFMS) as the mass detector. This method provides rapid and sensitive detection for fast CE separations due to its high mass spectral acquisition speed. The CE separation has been performed using a polybrene capillary coating to control the electroosmotic flow. The CE/IT/reTOFMS was applied in the characterization of hemoglobin variants by analyzing their mass peptide profiles resulting from enzymatic digestion of the proteins. Comparison of the peptide mass maps and the mass differences can readily identify the hemoglobin mutations, and single amino acid mutations can be detected. In order to analyze proteins extracted from the cells, capillary isoelectric focusing separation was interfaced to matrix-assisted laser desorption/ionization (MALDI) MS for bacterial protein analysis. A nitrocellulose membrane was used for sample collection from capillary isoelectric focusing (CIEF) separation and as the MALDI MS analysis substrate. This method provides high speed and high mass accuracy compared with the traditional 2-Dimensional (isoelectric focusing/sodium dodecyl sulfate-polyacrylamide gel electrophoresis) gel electrophoresis method. Two-dimensional separation by coupling CIEF to capillary zone electrophoresis (CZE) was investigated. The transfer of sample between the two separation columns and exchange of separation buffers were accomplished by implementing a hollow fiber tube between the columns. Complex peptide and protein mixtures were separated by CIEF/CZE with UV or mass detection. This 2-D separation system shows great potential in analysis of complex mixture such as protein extracts from the cells with mass spectrometric detection.
Les enzymes de l'espace extra‐cellulaire du stratum corneum (1992)

Synopsis Bien que le stratum corneum soit composé de cellules 'mortes', il est le siège d'une activité métabolique très importante. Mais, contrairement à la plupart d'autres tissus, cette activité a la particularité d'étre extra-cellulaire. Elle est due à des enzymes excrétées par les Corps d'Odland avec les bicouches céramidiques. Ces enzymes sont des hydrolases, elles sont identiques ou très proches de celles des lysosomes. Les principales activités observées correspondent à une (ou des) glycosidase(s), une phospholipase, une sphingomyélinase, une phosphatase, une (ou des) estérase(s), des sulfatases, des protéases. Comme les hydrolases des lysosomes, elles semblent peu spécifiques. Ce pool enzymatique pourrait jouer plusieurs rôles fondamentaux, notamment: 1. La transformation des bicouches gluco-céramidiques en bicouches ceramidiques plus lipophiles; 2. L'élimination de la membrane plasmique, dont certains produits du catabolisme, comme les acides gras et les céramides, peuvent être intégrés aux bicouches céramidiques; 3. La diminution de la cohésion entre les cornéocytes; 4. La protection contre l'intrusion de corps étrangers. Comme tout système enzymatique, les hydrolases extra-cellulaires, sont certainement soumises à des régulations. Plusieurs de ces régulations sont envisagées. A partir de considérations d'enzymologie, le pH de la base du stratum corneum peut être estiméà environ 5. En cosmétologie, les enzymes du stratum corneum sont mises à contribution pour rendre actifs des précurseurs. L'étude des conséquences des modifications de l'activité enzymatique sur l'état de la peau pourrait constituer une future voie de recherche extrêmement prometteuse.
Crowd counting via region based multi-channel convolution neural network (2017)

This paper proposed a novel region based multi-channel convolution neural network architecture for crowd counting. In order to effectively solve the perspective distortion in crowd datasets with a great diversity of scales, this work combines the main channel and three branch channels. These channels extract both the global and region features. And the results are used to estimate density map. Moreover, kernels with ladder-shaped sizes are designed across all the branch channels, which generate adaptive region features. Also, branch channels use relatively deep and shallow network to achieve more accurate detector. By using these strategies, the proposed architecture achieves state-of-the-art performance on ShanghaiTech datasets and competitive performance on UCF_CC_50 datasets.
Cholinergic control of epidermal cohesion (2006)

The non-neuronal cholinergic system of human epidermis includes the keratinocyte (KC) acetylcholine (ACh) axis composed of the enzymes mediating ACh synthesis and degradation, and two classes of ACh receptors, the nicotinic and muscarinic ACh receptors, mediating biological effects of the cutaneous cytotransmitter ACh. Regulation of KC cell-cell and cell-matrix adhesion is one of the important biological functions of cutaneous ACh. The downstream targets of ACh effects mediated by distinct ACh receptor subtypes include both the intercellular adhesion molecules, such as classical and desmosomal cadherins, and integrins mediating KC adhesion to a substrate. The signaling pathways include activation or inhibition of kinase cascades resulting in either up- or down-regulation of the expression of cell adhesion molecules or changes in their phosphorylation status, or both. The components of the KC ACh axis are involved in cutaneous blistering in patients with autoimmune pemphigus, junctional and dystrophic forms of epidermolysis bullosa, thermal burns, and mustard-induced vesication. Recent progress with the development of antiacantholytic therapies of patients with pemphigus using cholinomimetics indicates that cholinergic drugs may be a promising approach for other cutaneous blistering disorders.
Advances in Microfluidics (2012)

Advances in Microfluidics provides a current snapshot of the field of microfluidics as it relates to a variety of sub-disciplines. The chapters have been divided into three sections: Fluid Dynamics, Technology, and Applications, although a number of the chapters contain aspects that make them applicable to more than one section. It is hoped that this book will serve as a useful resource for recent entrants to the field as well as for established practitioners.
Efficient two-dimensional interleavingtechnique by use of the set partitioningconcept (1996)

The authors propose an efficient two-dimensional interleaving technique which spreads a cluster of errors having a quasicircular shape. As a consequence, simple one-dimensional random-error-correcting codes can be used to correct this kind of cluster, instead of the more complex two-dimensional burst-error-correcting codes.
An optimum diversity-combining technique for FFH/MFSK communication systems over frequency-selective fading channels with multitone jamming (2009)

An optimum maximum-likelihood (ML) receiver is proposed and analyzed for fast frequency-hopped M-ary frequency-shift keying systems over frequency-selective Rayleigh-fading channels with multitone jamming and additive white Gaussian noise. The analytical bit-error rate expressions of the proposed optimum ML receiver are also derived based on the characteristic function approach, which is applicable for higher diversity orders. Analytical results, validated by simulation results, show that the proposed optimum ML receiver significantly outperforms some commonly used conventional receivers. Our analysis also shows that there exists an optimum diversity order under certain channel conditions.
Possible Beneficial Effect of Telmisartan on Glycemic Control in Diabetic Subjects (2005)

In a recent issue of Diabetes Care , Pershadsingh and Kurtz (1) reported an interesting case subject with impaired glucose tolerance, whose insulin resistance and triglycerides improved on the angiotensin II type 1 receptor blocker telmisartan. Telmisartan has a unique agonist activity of the peroxisome proliferator–activated receptor γ (PPARγ) in vitro (2). It reduces glucose, insulin, and triglyceride levels in rats fed a high-fat, high-carbohydrate diet (2). These results suggest that telmisartan may have a beneficial effect on glycemic control in type 2 diabetes.

We investigated the effect of …
Flexible register window structure for multi-tasking (2002)

A multiple register windowing technique was recently employed by various systems which emphasizes fast procedure (function) calls. However, it has one major problem to overcome: the high overhead associated with context switching. For this unique technique to become attractive for system designers, it requires architectural support to minimize the overhead encountered by frequent task switching. The paper proposes an efficient way to resolve this critical disadvantage of the windowing technique. To avoid the severe time consuming process for switching tasks, and to retain the advantages of multiple register window philosophy, one approach-utilizing a flexible register window file-is presented and analyzed for both inter-procedure and inter-task operations. Design tradeoffs are examined in an analytic study, the results of which are summarized in the conclusion.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Chlorination of N,N-Dimethylaniline (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chlorination of N,N-DimethylanilineT. H. CHAO and L. P. CIPRIANICite this: J. Org. Chem. 1961, 26, 4, 1079–1081Publication Date (Print):April 1, 1961Publication History Published online1 May 2002Published inissue 1 April 1961https://pubs.acs.org/doi/10.1021/jo01063a024https://doi.org/10.1021/jo01063a024research-articleACS PublicationsRequest reuse permissionsArticle Views220Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High current density in bulk YBa2Cu3O<i>x</i> superconductor (1989)

A liquid phase processing method for the fabrication of bulk YBa2Cu3Ox superconductors with large current carrying capacity has been developed. Slow cooling through the peritectic transformation (1030–980 °C) has been shown to control the microstructure of these superconductors. A cooling rate of 1 °C/h in this temperature range has yielded a microstructure with long plate type, thick grains oriented over a wide area. Current density up to 18 500 A/cm2 has been obtained by continuous direct current measurements and in excess of 62 000 A/cm2 with pulse current of 10 ms duration and 75 000 A/cm2 using 1 ms pulse. The strong magnetic field dependence observed in sintered bulk 1-2-3 superconductors is also minimized to a large extent where a current density in excess of 37 000 A/cm2 is obtained in a field of 6000 G.