gebhart/patrepeval huggingface dataset:
Regional Differences in the Cellular Immune Response to Experimental Cutaneous or Visceral Infection with<i>Leishmania donovani</i> (1998)

ABSTRACT Infection with the protozoan Leishmania donovani can cause serious visceral disease or subclinical infection in humans. To better understand the pathogenesis of this dichotomy, we have investigated the host cellular immune response to cutaneous or visceral infection in a murine model. Mice infected in the skin developed no detectable visceral parasitism, whereas intravenous inoculation resulted in hepatosplenomegaly and an increasing visceral parasite burden. Spleen cells from mice with locally controlled cutaneous infection showed strong parasite-specific proliferative and gamma interferon (IFN-γ) responses, but spleen cells from systemically infected mice were unresponsive to parasite antigens. The in situ expression of IFN-γ, interleukin-4 (IL-4), IL-10, IL-12, and inducible nitric oxide synthase (iNOS) mRNAs was determined in the spleen, draining lymph node (LN), and cutaneous site of inoculation. There was considerably greater expression of IFN-γ and IL-12 p40 mRNAs in the LN draining a locally controlled cutaneous infection than in the spleen following systemic infection. Similarly, there was a high level of IFN-γ production by LN cells following subcutaneous infection but no IFN-γ production by spleen cells following systemic infection. Splenic IL-4 expression was transiently increased early after systemic infection, but splenic IL-10 transcripts increased throughout the course of visceral infection. IL-4 and IL-10 mRNAs were also increased in the LN following cutaneous infection. iNOS mRNA was detected earlier in the LN draining a cutaneous site of infection compared to the spleen following systemic challenge. Thus, locally controlled cutaneous infection was associated with antigen-specific spleen cell responsiveness and markedly increased levels of IFN-γ, IL-12, and iNOS mRNA in the draining LN. Progressive splenic parasitism was associated with an early IL-4 response, markedly increased IL-10 but minimal IL-12 expression, and delayed expression of iNOS.
Intraoperative autotransfusion in major elective vascular operations: a clinical assessment. (1976)

Six patients undergoing major elective vascular operations received an average of 1,700 ml. of intraoperative autotransfusion of shed blood. The patients were anticoagulated systemically during operation. The mean platelet count (156,000 per cubic millimeter and fibrinogen value (257 mg. per 100 ml.) were normal in autotransfused blood and the mean hemoglobin level was slightly below normal (11.5 Gm. per 100 ml.). Plasma hemoglobin values were variable. No patient suffered any complication that could be attributed to autotransfusion. Donor blood transfusion was avoided in five of the six patients by salvage and reinfusion of shed blood. No evidence of coagulopathy was found in any patient as measured by platelet count, fibrinogen level, prothrombin time, partial thromboplastin time, euglobulin clot lysis, and fibrin degradation products. The technique of intraoperative autotransfusion is described in detail.
Security Meter: A Practical Decision-Tree Model to Quantify Risk (2005)

Several security risk templates employ nonquantitative attributes to express a risk's severity, which is subjective and void of actual figures. The author's design provides a quantitative technique with an updated repository on vulnerabilities, threats, and countermeasures to calculate risk.
The career experiences of industrial and organisational psychology graduates (2013)

A survey of 53 graduates of industrial and organizational psychology masters programs, from the four universities in New Zealand offering such programs (Auckland, Canterbury, Massey, Waikato), was conducted to explore their early career experiences. The survey confirms that industrial and organizational psychology graduates are reasonably successful in establishing careers within the discipline with most graduates working in related fields. Recommendations for students pursuing careers and universities offering such programs are suggested. The information derived from this study is potentially of benefit to future graduates and others who may be considering a career in the field of industrial and organizational psychology, and to the convenors of the respective university programs.
Making Sense of Multiple Interpretations (2004)

Some teaching innovations arise from a combination of good intentions, last-minute planning, and incredible luck. Colgate University hired me in late July 1997 as a visiting professor for the fall semester. As I scrambled to finish my dissertation and move my family, only a few days remained to pull together the syllabus for a course on Race and Education . I wanted to begin this contemporary course with an historical focus, delving into African-American experiences with school desegregation during the mid twentieth century, but could not decide on which of the many excellent historical case studies to assign. The bookstore wanted my order as soon as possible. So I ordered two books—David Cecelski's Along Freedom Road and Vanessa Siddle Walker's Their Highest Potential —hoping that at least one would arrive on time. When both magically appeared on the bookstore shelves a day before the first class, I decided to innovate and revised the syllabus. Half of the students would read Cecelski; the other half would read Walker. Despite some initial confusion, my students began to engage in serious discussions over historical interpretations of school desegregation, demonstrating a level of depth that would not have happened had I assigned only one book to the entire class.
Prolongation of repolarization time by electric field stimulation with monophasic and biphasic shocks in open-chest dogs. (1991)

Recent studies suggest that 1) electrically induced fibrillation and defibrillation involve prolongation of refractoriness by the shock in addition to stimulation and 2) biphasic waveforms are more efficient for defibrillation than are comparable monophasic waveforms. The purpose of this study was to compare prolongation of action potential duration at 50% repolarization by monophasic and biphasic shocks during paced rhythm. A floating glass microelectrode was used to record intracellularly from the anterior right ventricular epicardium in seven open-chest dogs. After 10 S1 beats paced at an interval of 350 msec, 5-msec and 2.5-msec monophasic shocks and biphasic shocks, with each phase of 2.5 msec, were given via mesh electrodes on either side of the microelectrode. The shock strength was adjusted so that the shock field, measured from eight extracellular electrodes encircling the microelectrode, was about 5 V/cm. Monophasic and biphasic S2 shocks were given starting with an S1-S2 interval of 120 msec, w...
A Husband for Emily Dickinson: Building a Staircase for the Colemans; Setting Forms for a Sidewalk along Main Street; Spading the Fowlers' Garden; Erecting Posts for the Gas Lamps; Carting off the Printer's Waste; Roofing the First Congregational Church (2000)

A Husband for
How to Write Poetry (1955)

Some of the different definitions and their interpretations in order to write poetry are discussed. The different ways in which poetry can be attempted to be written are highlighted.
Proinflammatory biomarkers' level and functional genetic polymorphisms in periprosthetic joint infection (2018)

Level III, diagnostic study.
Engineering Aspects of Emulsion Polymerization (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEngineering Aspects of Emulsion PolymerizationSidney J. BaumCite this: Ind. Eng. Chem. 1957, 49, 11, 1797–1802Publication Date (Print):November 1, 1957Publication History Published online1 May 2002Published inissue 1 November 1957https://pubs.acs.org/doi/10.1021/ie50575a018https://doi.org/10.1021/ie50575a018research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
EVOLUTIONARY RELATIONSHIPS AND STRUCTURAL MECHANISMS OF AAA+ PROTEINS (2006)

Complex cellular events commonly depend on the activity of molecular "machines" that efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An essential and expanding subset of these assemblies comprises proteins of the ATPases associated with diverse cellular activities (AAA+) family. The defining feature of AAA+ proteins is a structurally conserved ATP-binding module that oligomerizes into active arrays. ATP binding and hydrolysis events at the interface of neighboring subunits drive conformational changes within the AAA+ assembly that direct translocation or remodeling of target substrates. In this review, we describe the critical features of the AAA+ domain, summarize our current knowledge of how this versatile element is incorporated into larger assemblies, and discuss specific adaptations of the AAA+ fold that allow complex molecular manipulations to be carried out for a highly diverse set of macromolecular targets.
Antiulcerogenic activity of zinc acexamate in different experimental models. (1987)

The antiulcerogenic activity of zinc acexamate (ZAC; Laboratorios Viñas, S.A.) has been tested in several models of gastric injury induced by acid hypersecretion, prostaglandin blockade and disruption of the gastric barrier. Lowest doses which have demonstrated to significantly prevent gastric damage ranged from 10 to 100 mg/kg depending on the experimental model used. The benefit obtained with this compound was always dose-dependent. These findings would support the hypothesis that ZAC acts by a complex inhibition of several of the mechanisms involved in the development of peptic diseases.
Dehydrogenation of Methylcyclopentane over Chromia-Alumina Catalysts (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDehydrogenation of Methylcyclopentane over Chromia-Alumina CatalystsHeinz. HeinemannCite this: Ind. Eng. Chem. 1951, 43, 9, 2098–2101Publication Date (Print):September 1, 1951Publication History Published online1 May 2002Published inissue 1 September 1951https://pubs.acs.org/doi/10.1021/ie50501a035https://doi.org/10.1021/ie50501a035research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria. (1996)

Although the production of NO within rodent phagocytes is well-characterized, its production and function within human phagocytes are less clear. We show here that neutrophils within human buffy coat preparations stimulated with a mixture of interleukin 1, tumor necrosis factor alpha, and interferon gamma contain inducible NO synthase mRNA and protein, one of the enzymes responsible for NO production. The protein colocalizes with myeloperoxidase within neutrophil primary granules. Using an inhibitor of NO synthase, L-N-monomethyl arginine, we show that activity of this enzyme is required for the formation of nitrotyrosine around phagocytosed bacteria, most likely through the intermediate production of peroxynitrite, a reaction product of NO and superoxide anions.
DE CURANDEROS A MÉDICOS. UNA APROXIMACIÓN A LA HISTORIA SOCIAL DE LA MEDICINA EN COSTA RICA: 1800-1949 (2000)

En 1929, el renombrado escritor Jenaro Cardona publicaba una colección decuentos llamada “Del Calor hogareño”. Dentro de esa compilación destacaba un satírico relato que narraba los episodios cotidianos de un curandero de pueblo.
Removal of EOG Artifacts from EEG Recordings Using Stationary Subspace Analysis (2014)

An effective approach is proposed in this paper to remove ocular artifacts from the raw EEG recording. The proposed approach first conducts the blind source separation on the raw EEG recording by the stationary subspace analysis (SSA) algorithm. Unlike the classic blind source separation algorithms, SSA is explicitly tailored to the understanding of distribution changes, where both the mean and the covariance matrix are taken into account. In addition, neither independency nor uncorrelation is required among the sources by SSA. Thereby, it can concentrate artifacts in fewer components than the representative blind source separation methods. Next, the components that are determined to be related to the ocular artifacts are projected back to be subtracted from EEG signals, producing the clean EEG data eventually. The experimental results on both the artificially contaminated EEG data and real EEG data have demonstrated the effectiveness of the proposed method, in particular for the cases where limited number of electrodes are used for the recording, as well as when the artifact contaminated signal is highly nonstationary and the underlying sources cannot be assumed to be independent or uncorrelated.
Laminar morphology in polymer blends: Structure and properties (1987)

Abstract Polymer‐polymer blends offer a route for enhancement of various properties. When immiscible polymers are blended together (in the presence of a compatibilizer), the blend properties are dependent on the morphology of the phases. Uniform, fine dispersions generally result in “average” properties. Discussed here are blends of polyamides or polyesters with polyolefins, particularly polyethylene, where small amounts (3–20 percent) of the former polymers dispersed as essentially parallel, thin, large laminae produce substantial reduction (3–100 times) of permeability properties in blow‐molded/extruded articles. Physical properties of such blends, their permeability properties, and morphologies are discussed.
Heterogeneous integration for IoT Cloud and Smart Things a Roadmap for the future (2016)

Smart Electronics, IoE connected devices, Smart Things, and Cloud constitute over 50% of Global Electronic System Revenue. Progress for IoT, Smart Devices & the Cloud will require deep collaboration and partnership internally and externally across ecosystems and the whole technical community. Heterogeneous Integration Roadmap for Semiconductor (HITRS) will continue the role of ITRS providing guidance to industry, academia and research community in the era of IoE, Smart Things and Cloud Infrastructure.
Changing issues of quality control: diploid and non-diploid cell lines. (1992)

Early viral vaccines were prepared from primary monkey kidney cell cultures. However, primary cell cultures can be highly variable and also present a risk of contamination by endogenous viruses. The development of human diploid cell lines for vaccine production provide greater assurance of consistency and freedom from contaminating viruses. Continuous cell lines present considerable advantages in the preparation of proteins for therapeutic use. The perceived risks associated with the use of these cell lines include those of retroviral contamination, oncogenic DNA and consistency of final product during the extended life in culture. Advances in molecular biologic and analytical chemistry procedures have enabled extensive characterisation not only of the cells, but also of the product itself. The degree of testing which can now be performed on the product, to ensure its safety and consistency, should lead to a reappraisal of testing regimes applied to the cells themselves.
Impact of a Computer-based Patient Record System on Data Collection, Knowledge Organization, and Reasoning (2000)

Technology has a profound influence in shaping cognitive behavior, and the potential effects of cognition on technology design needs to be explored.
Standard covariant formulation for perfect-fluid dynamics (1988)

After a brief description of the Milne generalization of the Galilean invariance group for the space–time of Newtonian kinematics, it is shown how the generalized Eulerian dynamical equations for the motion of a multiconstituent perfect (nonconducting) fluid can be expressed in terms of interior products of current 4-vectors with exterior derivatives of the appropriate 4-momentum 1-forms (whose role is central in this approach) in a fully covariant standard form whose structure is identical in the Newtonian case to that of the corresponding equation for the case of (special or general) relativistic perfect fluid mechanics. In addition to space–time covariance, this standard form exhibits chemical covariance in the sense that it is manifestly invariant under redefinition of the number densities of the independent conserved chemical constituents in terms of linear combinations of each other. It is shown how, in the strictly conservative case when no chemical reactions occur, this standard form, can be used (via the construction of suitably generalized Clebsch potentials) for setting up an Eulerian (fixed-point) variation principle in a form that is simultaneously valid for both Newtonian and relativistic cases.
Formal specification of geographic data processing requirements (1990)

A formal foundation for the specification of geographic data processing (GDP) requirements is established. Emphasis is on modeling data and knowledge requirements rather than processing needs. A subset of first-order logic is proposed as the principal means for constructing formalizations of the GDP requirements in a manner that is independent of the data representation. Requirements executability is achieved by selecting a subset of logic, compatible with the inference mechanisms available in Prolog. Concepts with GDP significance such as time, space, and accuracy are added for the formalization without losing Prolog implementability or separation of concerns. Rules of reasoning about time, space, and accuracy can be compactly stated in a subset of second-order predicate calculus and can be easily modified to meet the particular needs of a specific application. The feasibility of the approach is established with the aid of a prototype implementation of the formalism in Prolog. The implementation also provides the means for the graphical rendering of logical information on a high-resolution color display.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Methods for visual mining of data in Virtual Reality (2001)

Abstract. Recent advances in technology have made it possible to use 3-D Virtual Reality for Visual Data Mining. This paper presents a modular system architecture with a series of tools for explorative analysis of large data sets in Virtual Reality. A 3-D Scatter Plot tool is extended to become an ”Object Property Space”, where data records are visualized as objects with as many statistical variables as possible represented as object properties like shape, color, etc. A working hypothesis is that the free and real-time navigation of the observer in the immersive virtual space will support the chances of finding interesting data structures and relationships. The system is now ready to be used for experiments to validate the hypothesis.
Minor hallucinations occur in drug‐naive Parkinson's disease patients, even from the premotor phase (2015)

In this first study to prospectively analyze the frequency of minor hallucinatory phenomena in incident, untreated PD patients, hallucinations appeared as a frequent early non-motor symptom that may even predate the onset of parkinsonism.
Anxiety and depression after mild head injury: a case control study. (1988)

Thirty-five patients and corresponding matched controls were investigated between 5 and 17 months from mild head trauma using the Self Rating Depression Scale and the State-Trait Anxiety Inventory. The findings indicate that compared with an appropriate control group mild head injured patients are at risk of developing depression, whereas their liability to anxiety is not increased. Our results strongly suggest that all head injured patients should be screened for depression.
An Adaptive Estimation of Dimension Reduction Space (2002)

Summary Searching for an effective dimension reduction space is an important problem in regression, especially for high dimensional data. We propose an adaptive approach based on semiparametric models, which we call the (conditional) minimum average variance estimation (MAVE) method, within quite a general setting. The MAVE method has the following advantages. Most existing methods must undersmooth the nonparametric link function estimator to achieve a faster rate of consistency for the estimator of the parameters (than for that of the nonparametric function). In contrast, a faster consistency rate can be achieved by the MAVE method even without undersmoothing the nonparametric link function estimator. The MAVE method is applicable to a wide range of models, with fewer restrictions on the distribution of the covariates, to the extent that even time series can be included. Because of the faster rate of consistency for the parameter estimators, it is possible for us to estimate the dimension of the space consistently. The relationship of the MAVE method with other methods is also investigated. In particular, a simple outer product gradient estimator is proposed as an initial estimator. In addition to theoretical results, we demonstrate the efficacy of the MAVE method for high dimensional data sets through simulation. Two real data sets are analysed by using the MAVE approach.
Activated coagulation time of whole blood (1966)

The determination of the coagulation time of whole blood, as usually performed, has proven an inadequately sensitive means of detecting hemorrhagic diatheses. Many patients with low-grade but potentially dangerous hemophilioid disorders show clotting times well within the normal range. This insensitivity results from two well-established characteristics of the coagulation mechanism: (1) Contact activation, the first and clinically least important stage of the process, requires most of the time of coagulation. (2) Unavoidable variations in degree of contact activation in drawing and observing the blood obscure any but the greatest increases in time of the shorter and more important stages of the process. Insensitivity is therefore inherent in the measurement of coagulation time unless one either eliminates the period of contact activation or, at least, drastically and uniformly shortens it. Many workers have used particulate materials with large surface area to effect quick and maximal contact activation of plasma. In 1958