gebhart/patrepeval huggingface dataset:
Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters. (1994)

The prototype mammalian proprotein processing enzyme furin is shown to be encoded by three distinct FUR mRNA isoforms which differ only in their 5'-untranslated regions. By primer extension analysis, the transcription start sites of the three mRNA isoforms were defined. The genomic regions located immediately upstream of the three alternative transcriptional start sites were shown to possess promoter activity in transfection experiments using the luciferase encoding gene as reporter. In a liver cell line, the P1 promoter appeared to be the strongest; in a lung cell line, the P1A promoter. Human FUR promoter P1 but not P1A or P1B was transactivated by transcription factor C/EBP beta. Other members of this family of bZIP transcription factors, C/EBP alpha and C/EBP delta, were not able to transactivate the P1 promoter. Promoter P1A and P1B have characteristics of promoters of housekeeping genes. They lack TATA or CAAT boxes upstream of the transcription start site but are very GC-rich and contain several SP1 sites. Promoter P1, on the other hand, has a TATA box in the proximal promoter region. In electromobility shift assays and DNase I footprinting analysis, transcription factor SP1 was found to bind to the proximal region of the P1 promoter. Altogether, our results indicate that expression of the human FUR gene is directed by alternative promoters, housekeeping (GC-rich) as well as regulated (TATA-containing) promoters, suggesting that their differential use may be a mechanism to modulate levels of the furin enzyme.
Electronic Commerce Application in Tourism Agents (2012)

Tourism agents of distribution are organizational links in a travel product producer's system of describing, selling, and confirming travel arrangements to the buyer. Such channels are needed because it is impractical for any supplier to own sales outlets in every market city. It is much more feasible and productive to distribute the product, for example, through 25,000 retail travel agencies. There are specialty channels of many kinds. The Electronic Commerce is a new force in the sale of travel today. It will grow in importance in the future and have an impact on the travel distribution system. Travel distribution channels are similar to those used in other industries. But tourism products are intangible. Then the particular travel product can be integrated into the distributor's operation. Some channels are very evident, such as travel agencies. However, depending on the individual product, additional distributors, such as incentive travel firms, corporate travel departments, hotel sales reps, and associations, can be very sales-effective.
Effects of alpha-tocopherol administration on red blood cell membrane lipid peroxidation in hemodialysis patients. (1984)

The result of vitamin E treatment in 19 uremic patients in chronic hemodialysis is evaluated. In particular, the levels of erythrocyte malonyldialdehyde (MDA) and vitamin E were determined, and the fatty acid composition of red blood cell (RBC) membrane before and after treatment with parenterally administered vitamin E. A decrease of RBC MDA levels, an increase of RBC vitamin E concentrations, and a decreased saturated fatty acid to unsaturated fatty acid ratio were found after treatment with vitamin E. There was a statistically significant increase of the packed RBC volume.
Patients with Pulmonary Tuberculosis Develop a Strong Humoral Response against Methylated Heparin-Binding Hemagglutinin (2005)

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
Tractive Resistance of Cohesive Channels (1959)

Report of laboratory study on tractive resistance characteristics of some cohesive soil samples taken from canal beds in order to discover set of characteristics useful in estimating resistance to erosion for soils in which waterways are proposed.
Studies on the kinetics and initiation mechanism of acrylamide polymerization using persulfate/aliphatic diamine systems as initiator (1990)

Abstract The effects of various aliphatic diamines on vinyl polymerization using ammonium persulfate as initiator were studied. It was found that diamines with two amino groups separated by an ethylene unit possess higher promoting activities than those with two amino groups linked by other α,ω‐alkylene units such as methylene or propylene. The promoting activities of diamines on vinyl polymerization are in the order: tertiary diamine > secondary diamine > primary diamine. The methyl group is a preferred substituent at the amino groups of the diamine, being faster oxidized by persulfate (to produce the dialkylaminomethyl free radical) than the α‐methylene groups. The primary free radicals produced through redox‐reaction of persulfate and aliphatic diamines were studied using the spin trapping technique and ESR spectroscopy. An initiation mechanism of persulfate/aliphatic diamine systems is proposed.
A VHF technique for space‐time mapping of lightning discharge processes (1978)

Instrumentation using fast logic circuits and a wide band receiving system (20–80 MHz) to determine direction of arrival of individual VHF electromagnetic impulses from lightning discharge processes was tested successfully at the Kennedy Space Center (KSC) during the 1976 Thunderstorm Research International Program (Trip 76). Time difference of arrival of impulses was used to measure the azimuth from a pair of horizontally spaced antennas and the elevation from a pair of vertically spaced antennas. Although the base line of each pair was only 13.74 m, the time difference measurements were made with 0.4‐ns resolution so that the direction to the source could be determined to an accuracy of ±0.5°. Directions of the individual impulses were represented in real time on a 60° azimuth and 30° elevation format and photographed with a 16‐mm movie camera. Two stations separated by about 17.8 km simultaneously recorded direction data for discharges from over three dozen thunderstorms in the KSC area. A description of this technique and the results of the Florida tests are presented. Analysis of these data revealed that (1) fine structure of lightning discharges could be accurately located and tracked with this technique by using triangulation methods, (2) branching and structure in the discharge processes could be observed, (3) most lightning activity occurred about 5–6 km high, near the −10°C temperature level, and (4) considerable movement of discharge centers occurred as the lightning processes permeated the thunderstorm volume at progression speeds of about 50–150 km/s.
Dual-Band Broadband Antennas for SAR Applications (2006)

For dual-band high-resolution synthetic aperture radar applications, an efficient array design is investigated. The operating frequencies are at X and C-band, centered about 10.0 and 5.5 GHz, respectively. The X-band antenna is a ridged waveguide slotted resonant array, which is subarrayed to improve, the bandwidth. The cavity-fed slot antennas are used to obtain a wide bandwidth for the C-band radiator elements. The use of ridged waveguide for X-band saves a space between linear arrays, which are structured into chokes to depress the coupling. Simultaneously, the spaces are enveloped into cavity slot antennas for the C-band applications. The dual-band antennas achieve a wide bandwidth up to 1.0 GHz
Rates and Associated Factors of Secondary Mental Health Care Utilisation among Ex-Military Personnel in the United States: A Narrative Review (2019)

Little is known about ex-serving military personnel who access secondary mental health care. This narrative review focuses on studies that quantitatively measure secondary mental health care utilisation in ex-serving personnel from the United States. The review aimed to identify rates of mental health care utilisation, as well as the factors associated with it. The electronic bibliographic databases OVID Medline, PsycInfo, PsycArticles, and Embase were searched for studies published between January 2001 and September 2018. Papers were retained if they included ex-serving personnel, where the majority of the sample had deployed to the recent conflicts in Iraq or Afghanistan. Fifteen studies were included. Modest rates of secondary mental health care utilisation were found in former military members-for mean percentage prevalence rates, values ranged from 12.5% for at least one psychiatric inpatient episode, to 63.2% for at least one outpatient mental health appointment. Individuals engaged in outpatient care visits most often, most likely because these appointments are the most commonly offered source of support. Post-traumatic stress disorder, particularly re-experiencing symptoms, and comorbid mental health problems were most consistently associated with higher mental health care utilisation. Easily accessible interventions aimed at facilitating higher rates of help seeking in ex-serving personnel are recommended.
La noche delincuente: La representatión del prostituto en<i>El vampiro de la colonia Roma, Las púberes canéforas y La Virgen de los Sicarios</i> (2003)

Abstract En años recientes se ha empezado a discutir y teorizar la prostitutión femenina con un punto de vista diferente al de la condena o el lamento por las trabajadoras sexuales, un acercamiento que ha sido encontrado principalmente en textos sociológicos. El tabñ ha sido añn mayor cuando se ha tratado de escribir o discutir abiertamente el tema de la prostitutión masculina, especialmente como ha sido practicada por hombres jóvenes. Este articulo busca corregir esta omisión al analizar la dinámica y la representatión de la prostitution masculina en las novelas de tres escritores homosexuales latinoamericanos mediante un análisis de la perspectiva narrativa empleada en cada una. Se procurará mostrar con referencia al uso de la voz narrativa cñmo dichas novelas proyectan ciertas imágenes del prostituto ‘marginado’ desde determinados puntos de vista. Se examinarán las siguientes novelas: dos de México, El vampiro de la colonia Roma 3 de Luis Zapata, Las pñberes canéforas de José Joaquín Blanco y una de Colombia, La Virgen de los Sicarios de Fernando Vallejo. Se analizará cómo los textos cuestionan, reiteran o circulan nociones de otredad articuladas y fomentadas en los discursos sobre ‘desviaciones’, delincuencia, criminalidad y sexualidad no-normativa, que definen el sujeto ‘marginal’ y lo colocan en esa positión de marginalidad.
Changes in messenger RNA levels for the subunits of ribonucleotide reductase during the cell cycle of leukemia L1210 cells. (1989)

Ribonucleotide reductase consists of two non-identical protein subunits that are required for enzyme activity. These subunits are encoded by different genes and are not expressed coordinately as the cells pass through the cell cycle. Using specific cDNAs for the non-heme iron (NHI) and the effector-binding (EB) subunits the levels of the mRNAs for these two subunits were determined in leukemia L1210 cells during the transition from the G0/G1 phase to the S and G2/M phases of the cell cycle. Synchronized populations of L1210 cells were obtained either by ethylene glycol-bis(beta-aminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA) treatment or by enrichment by elutriation centrifugation. The changes in the levels of the mRNAs for NHI and EB subunits were compared with the changes in the levels of the mRNAs for actin, p53, c-myc, thymidine incorporation into DNA, and DNA content by flow cytometric measurements. Synchronization of the cells by the two methods resulted in quantitative differences in the responses. The EGTA synchronized L1210 cells showed maximal increases of 9.3- and 5.7-fold in the mRNAs for the NHI and EB subunits, respectively. The peak level of the NHI mRNA was observed at 12 hr after the addition of calcium ions. The peak increase in the level of the mRNA for the EB subunit was observed between 12 and 15 hr after the addition of calcium ions. The rate of increase for the mRNA for c-myc was greater than the increase in the mRNA for the NHI subunit.(ABSTRACT TRUNCATED AT 250 WORDS)
Mi identidad a cambio de un plato de raíces (2011)

A prospective study of the dye properties of non-toxic lawsone thiophenyl derivatives, obtained using a green synthetic methodology allowed for the description of their bathochromic shifts in comparison to those of lawsone, a well-known natural pigment used as a colorant that recently also has aroused interest in dye-sensitized solar cells (DSSCs). These compounds exhibited colors close to red, with absorption bands in visible and UV wavelength range. The colorimetric study showed that these compounds exhibited a darker color than that of lawsone within a range of colors depending on the substituent in the phenyl ring. Computational calculations employing Density Functional Theory (DFT) and Time-Dependent Density Functional Theory (TD-DFT), showed that the derivatives have lower excitation energies than lawsone, while the alignment of their frontier orbitals regarding the conduction bands of TiO<sub>2</sub> and ZnO and the redox potential of the electrolyte I<sup>-</sup>/I<sub>3</sub><sup>-</sup> suggests that they could be employed as sensitizers. The study of the interactions of the lawsone and a derivative with a TiO<sub>2</sub> surface model by different anchoring modes, showed that the adsorption is thermodynamically favored. Natural bond orbital (NBO) analysis indicates a two-center bonding (BD) O-Ti as the main interaction of the dyes with TiO<sub>2</sub>.
C-reactive protein: risk assessment in the primary prevention of atherosclerotic disease. Has the time come for including it in the risk profile? (2001)

About half of patients presenting with myocardial infarction do not have the "classic" risk factors. This has stimulated a search for other factors that may be responsible and, when present, may help to predict which patients are at greatest risk for myocardial infarction and other cardiovascular events. With improved understanding of the pathogenesis of ischemic cardiovascular disease, we have gleaned new insights into potential markers of underlying atherosclerosis and cardiovascular risk. In recent years, data suggesting that certain markers of inflammation--both systemic and local--play a key role in the development and progression of atherosclerosis, and in its final clinical complications have accumulated. Specifically, elevated levels of one systemic marker of inflammation, C-reactive protein (CRP), are associated with an increased risk of cardiovascular disease events. Among several markers of systemic inflammation, CRP shows the strongest associations with vascular events, and the addition of CRP to total cholesterol dramatically improves risk prediction. CRP fulfils most of the requirements needed to serve as a new risk factor, but still several issues await further confirmation and clarification before this marker can ultimately be included in the routine risk profile. Moreover, potentially important associations have been established between elevated CRP levels and increased efficacy of established therapies, in particular lipid-lowering therapy with statins; CRP testing may enable us to tailor expensive cardiovascular medication to the individual patient. Such an improved prescription strategy might be especially valuable in the primary care setting where the absolute cardiovascular risk is considerably lower compared to that in secondary prevention.
Modeling the coverage and effectiveness of fault-management architectures in layered distributed systems (2003)

Increasingly, fault-tolerant distributed software applications use a separate architecture for failure detection instead of coding the mechanisms inside the application itself. Such a structure removes the intricacies of the failure detection mechanisms from the application, and avoids repeating them in every program. However, successful system reconfiguration now depends on the management architecture (which does both fault detection and reconfiguration), and on management subsystem failures, as well as on the application. This paper presents an approach which computes the architecture-based system reconfiguration coverage simultaneously with its performability.
Augmenting the maxillary sinus for implants (1994)

A method for restoring the posterior portion of the maxilla with a simultaneous composite alloplastic sinus lift graft and placement of press-fit implants is presented. Sinus grafting is needed because of minimal remaining alveolar bone. The composite graft material uses a combination of demineralized freeze-dried cortical bone and Interpore 200 hydroxyapatite. Since 1987, 45 sinus grafts with simultaneous placement of 111 root-form implants have been performed for 27 patients. None of the 76 restored implants have been lost. Complications were encountered in 2 patients (4 sinuses) who were heavy smokers. Antibiotics were administered, symptoms subsided, and the implants integrated.
Statement to Congress, December 16, 1998, (LTCM and the oversight of OTC derivatives transactions) (1999)

Hedging (Finance); Derivative securities; Financial leverage
Nucleoside analogues in the treatment of haematological malignancies (2001)

The nucleoside analogues are a group of antimetabolite cytotoxics which generally have to be metabolised to the equivalent nucleotide before incorporation into DNA. Cytarabine is a well established component of the treatment of acute leukaemias and has its principal action on dividing cells. New formulations include a liposome encapsulated product for intrathecal use and oral cytarabine ocfosfate which may be suitable for long-term outpatient use. Pentostatin acts by causing accumulation of deoxynucleotides and, although active against hairy cell leukaemia, is associated with a poor tolerance profile. Cladribine and fludarabine have substantial activity in the treatment of chronic lymphocytic leukaemia (CLL) and low-grade non-Hodgkin's lymphoma (NHL). Fludarabine is the more thoroughly investigated of the two and is currently being developed in combination therapies for CLL and NHL and also in a combination with cytarabine for acute myeloid leukaemia. Fludarabine's immunosuppressive activity is being exploited in the conditioning of patients for non-myeloablative stem cell transplantation. Gemcitabine is an established agent in the treatment of a number of solid tumours but also has activity in haematological malignancies which might be exploited by the use of extended infusion schedules. Newer agents including nelarabine, clofarabine and troxacitabine are undergoing clinical evaluation and show promising activity.
The Interfaces Group MIB (2000)

Status of this Memo This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the &quot;Internet Official Protocol Standards &quot; (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Copyright Notice
The Role of Ghrelin, Neuropeptide Y and Leptin Peptides in Weight Gain after Deep Brain Stimulation for Parkinson’s Disease (2012)

STN DBS seems to temporarily dysregulate the hypothalamic secretion of NPY and ghrelin. The variation of weight may be attributed to an increased production of ghrelin and leptin. A possible neuroprotective role of DBS, exerted through the increase of ghrelin levels, should be further studied.
Über bicyclische Heterocyclen mit gemeinsamem Stickstoffatom, IV. Amino‐imidazo[2.1‐<i>b</i>]thiazole (1962)

Abstract Aus 5‐Nitro‐ und 5‐Nitroso‐imidazo[2.1‐ b ]thiazolen wurden mit Zink in Eisessig 5‐Amino‐Derivate dargestellt. Sie sind im Gegensatz zu den analogen 4(5)‐Amino‐imidazolen relativ beständig und verhalten sich chemische wie aromatische Amine. — Bei der Umsetzung von 2.4‐Diamino‐thiazol mit ω‐Brom‐acetophenon bildete sich an Stelle des erwarteten 3‐Amino‐imidazo[2.1‐ b ]thiazols die 3‐Hydroxy‐Verbindung. — Ein 2‐Acetylamino‐imidazo[2.1‐ b ]thiazol wurde durch C URTIUS ‐Abbau erhalten.
The Life of Guy (2019)

Abstract This book is about the name “Guy” and its slow, mostly unnoticed development over four centuries since it began on November 5, 1605, with the suddenly famous Guy Fawkes, who was arrested just in time just before he could light the fuse on 36 barrels of gunpowder to blow up the House of Lords. During those four centuries, “Guy” became “guy,” the name for an effigy of Guy Fawkes burned at bonfires every November 5 since. The effigy was called a “guy,” so that more than one effigy would be “guys,” Then, slowly, “guy” extended its signification into a name for a ragged, lower-class male, then any strangely dressed male, then a neutral everyday word for just any male, a “guy.” To top it off, the 20th century extended the plural “guys” or “you guys” to include all human beings, even women speaking to groups of women. None of these developments were made deliberately; the word just quietly slipped by, except for opposition from some Southerners and feminists who objected to it on the grounds that it wasn’t “y’all” and it wasn’t gender neutral. It has become all the more entrenched because now it’s the standard second-person plural pronoun for most of us who speak English.
Desmopressin-Induced Severe Hyponatremia with Central Pontine Myelinolysis: A Case Report (2018)

Desmopressin, a synthetic vasopressin analog, is used to treat central diabetes insipidus, hemostatic disorders such as von Willebrand's disease, and nocturnal enuresis. We present the case of a 69-year-old man who developed severe hyponatremia during treatment with intranasal desmopressin at 10 µg twice daily for chronic polyuria and nocturia thought to be due to central diabetes insipidus. After 5 months of therapy, the patient noticed progressive fatigue, anorexia, dizziness, weakness, light-headedness, decreased concentration, and new-onset falls. At 6 months of therapy, the patient was brought to the emergency department for altered mental status and was found to be severely hyponatremic with a serum sodium level of 96 mmol/L, down from a value of 134 mmol/L at the initiation of therapy. The intranasal desmopressin was discontinued and the patient was admitted to the intensive care unit where the hyponatremia was slowly corrected over the next week to 132 mmol/L, never increasing by more than 8 mmol/L a day, with careful fluid management. This included infusion of over 11 L of 5% dextrose to account for a high urine output, which peaked at 7.4 L in 1 day. However, while the recommended rate for sodium correction was followed, the patient's magnetic resonance imaging of the brain obtained after discharge displayed evidence of central pontine myelinolysis. Despite this finding, the patient eventually returned to his baseline mental status with no permanent neurologic deficits.
Automatic regulation systems with relevance to hearing aids. (1978)

Compression amplification in hearing aids has gained much interest in the recent years. Other types of nonlinear signal processing in hearing aids are developing. The principles of nonlinear signal processing through automatic regulation, as opposed to instanteaneously acting nonlinear signal transfer, is described in general. In particular the properties and terminology of amplitude compression and limiting circuits in relation to hearing aids are discussed. Several examples are given of nonlinear regulation systems for hearing aids involving other features than amplitude compression.