gebhart/patrepeval huggingface dataset:
Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes (2010)

The natural transfer of DNA from mitochondria to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as genome sequences attest. In humans, five different numts cause genetic disease and a dozen human loci are polymorphic for the presence of numts, underscoring the rapid rate at which mitochondrial sequences reach the nucleus over evolutionary time. In the laboratory and in nature, numts enter the nuclear DNA via non-homolgous end joining (NHEJ) at double-strand breaks (DSBs). The frequency of numt insertions among 85 sequenced eukaryotic genomes reveal that numt content is strongly correlated with genome size, suggesting that the numt insertion rate might be limited by DSB frequency. Polymorphic numts in humans link maternally inherited mitochondrial genotypes to nuclear DNA haplotypes during the past, offering new opportunities to associate nuclear markers with mitochondrial markers back in time.
MILTON'S REACTION TO HIS BLINDNESS (1960)

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A Re-Consideration of African Perspectives of Women, Gender and Development (2014)

Journal of Anthropology and Archaeology is a peer-reviewed international journal, which publishes original papers promoting theoretical, methodological and empirical developments in the discipline of socio-cultural anthropology.
Thyroid Hormone Metabolism: Regulation and Clinical Implications (1991)

This book is a review on the regulatory mechanisms of thyroid hormone metabolism. It covers the recent progress in basic biochemical and physiological studies and correlates this new information with clinical situations, such as non-thyroidal illnesses, the effects of drugs, age, and systemic illnesses on the metabolism of thyroid hormone. This should assist readers to understand better the physiological and biochemical basis of the disease process and thus to improve clinical management in patients with thyroidal and non-thyroidal illnesses. The book is intended for endocrinologists, especially thyroid researchers, paediatricians, and physiologists.
High-power single-mode emission from a broad-area semiconductor laser with a pseudoexternal cavity and a Fabry–Perot etalon (1997)

A simple pseudoexternal cavity with a commerically available broad-area laser diode, standard optics, and a thin FabryPerot etalon provides single-mode emission with 1-W optical power and a tuning range of ~0.5nm . The linewidth is estimated at 200MHz. Such high-power semiconductor laser systems are promising light sources for atomic physics, in which narrow-band high-power light is necessary, for example, for optical pumping of alkali metal vapor. Methods for expanding the tuning range and achieving higher narrow-band optical power are discussed.
The presence of methylated coumestans in annual <i>Medicago</i> species: Response to a fungal pathogen (1971)

The methylated coumestans 3'-methoxycoumestrol and 4'-methoxycoumestrol previously found in perennial medics were identified in annual Medicago species. Only 4'-methoxycoumestrol was present in sufficient quantity to affect the oestrogenic activity of the medic pastures. The total coumestan content varied with species, and was higher in plants grown on gravelly soils than on sands and higher in stems than pods, but in each case there was little change in the relative proportions of coumestrol and the methylated coumestans. Infection of leaves of a common burr medic with a leaf rust (Uromyces striatus) caused a sixfold increase (from 15 to 80 p.p.m.) in the total coumestan content. The increase, measured in leaves of equal age, was clearly related to the degree of rust infection.
Interaction of Blood Platelets with the Vessel Wall (1988)

This review summarizes current insights in the importance of endothelium in the interaction of platelets with the subendothelium. A greater part of the results described are obtained with the use of cultured vessel wall cells. The following subjects are discussed: (1) the pro- and antithrombotic properties of the endothelial cells; (2) the synthesis of subendothelium by the endothelial cells and the influence of the composition of the subendothelium on its reactivity towards blood platelets; (3) the effect of (purified) matrix and plasma proteins on the adhesion process, and (4) various abnormalities of platelet adhesion are discussed that lead to enhanced bleeding tendency or to increased thrombus formation.
Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol (1995)

Insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins (IGFBPs) were examined in Ishikawa endometrial cancer cells. Our findings suggest that about 95% of [125I]IGF-I is bound to membrane-associated IGFBPs rather than to IGF-I receptors. Specifically, [125I]IGF-I binding to cell membranes could be completely displaced by cold IGF-I or IGF-II, but not by insulin, suggesting that binding was primarily due to IGFBPs. This was confirmed by using [125I]des-(1-3)IGF-I as the ligand. Des-(1-3) IGF-I binds with high affinity to IGF-I receptors, but with markedly lower affinity to IGFBPs. [125I]Des-(1-3)IGF-I bound to Ishikawa cells was displaced by IGF-I, IGF-II, and insulin. These results suggest that measuring IGF-I receptor levels using labeled IGF-I may be misleading. Accordingly, we evaluated the differential binding of [125I]IGF-I and [125I]des-(1-3)IGF-I to study the involvement of the IGF system in the stimulation of Ishikawa cell growth by estradiol. IGF-I stimulates Ishikawa cell proliferation, but at low concentrations, and this stimulation is largely dependent on the presence of estradiol. Estradiol caused a 2.5-fold increase in IGF-I receptor levels. Moreover, estradiol reduced soluble IGFBP levels, presumably increasing the availability of IGFs for their receptors. This elevation in IGF-I receptor levels and the decrease in IGFBP levels were accompanied by a 3.5-fold increase in IGF-I receptor messenger RNA and a 2.5-fold decrease in IGFBP messenger RNAs. These experiments suggest that estradiol sensitizes endometrial cancer cells to the effects of IGFs by simultaneously elevating receptor levels and decreasing (potentially inhibitory) IGFBP levels.
Aligned ZnO Nanorod Arrays Grown Directly on Zinc Foils and Zinc Spheres by a Low-Temperature Oxidization Method (2009)

Vertically aligned, dense ZnO nanorod arrays were grown directly on zinc foils by a catalyst-free, low-temperature (450-500 degrees C) oxidization method. The zinc foils remain conductive even after the growth of ZnO nanorods on its surface. The success of this synthesis largely relies on the level of control over oxygen introduction. By replacing zinc foils with zinc microspheres, unique and sophisticated urchin-like ZnO nanorod assemblies can be readily obtained.
ESD Implantations for On-Chip ESD Protection With Layout Consideration in 0.18-&lt;tex&gt;$muhbox m$&lt;/tex&gt;Salicided CMOS Technology (2005)

One method to enhance electrostatic discharge (ESD) robustness of the on-chip ESD protection devices is through process design by adding an extra "ESD implantation" mask. In this work, ESD robustness of nMOS devices and diodes with different ESD implantation solutions in a 0.18-/spl mu/m salicided CMOS process is investigated by experimental testchips. The second breakdown current (I/sub t2/) of the nMOS devices with these different ESD implantation solutions for on-chip ESD protection are measured by a transmission line pulse generator (TLPG). The human-body-model (HBM) and machine-model (MM) ESD levels of these devices are also investigated and compared. A significant improvement in ESD robustness is observed when an nMOS device is fabricated with both boron and arsenic ESD implantations. The ESD robustness of the N-type diode under the reverse-biased stress condition can also be improved by the boron ESD implantation. The layout consideration in multifinger MOSFETs and diodes for better ESD robustness is also investigated.
Restimulation of Unconventional Reservoirs: When are Refracs Beneficial? (2010)

Abstract Restimulation treatments have been attempted in a wide variety of reservoirs, and more than 140 papers have been published documenting the success and failure of these efforts. A database of these published examples has been compiled and analyzed to identify the mechanisms responsible for production improvement following restimulation with propped fractures (refracs). A portion of this database was recently published (Vincent 2010), and specific field examples were highlighted to demonstrate that refrac treatments can improve production by numerous mechanisms including: – Enlarged fracture geometry – Improved pay coverage through increased fracture height in vertical wells – Greater lateral coverage in horizontal wells or initiation of more transverse fractures – Increased fracture conductivity compared to initial frac – Restoration of fracture conductivity loss due to embedment, cyclic stress, proppant degradation, gel damage, scale, asphaltene precipitation, fines plugging, etc. – Increased conductivity in previously unpropped or inadequately propped portions of fracture – Use of more suitable fracturing fluids – Reorientation due to stress field alterations, leading to contact of "new" rock This paper will briefly review restimulation attempts in six Canadian reservoirs of interest to the local audience, and will then present a more detailed review of restimulation of horizontal wells in the unconventional Bakken oil formation. In addition to a summary of published results, this paper will introduce a significant amount of previously unpublished data regarding refrac treatments of horizontal laterals completed in the Middle Bakken. This study will identify several additional concerns and opportunities with restimulating horizontal wellbores that were not previously identified in literature reviews. This organized summary of field results and references will provide significant value to readers evaluating or designing restimulation treatments.
Particle Swarm Fuzzy Controller for Behavior-based Mobile Robot (2006)

The attractive researches in the field of mobile robotics is behavior-based mobile robots. Behavior-based approach should have an ideal controller to generate perfect behavior action and able to handle conflicting ones that are seemingly irreconcilable. Schemas to overcome these problems based on fuzzy logic controller (FLC) are provided, known as fuzzy behavior-based robot. This paper presents a novel approach that the fuzzy membership functions and fuzzy rule bases are tuned automatically by particle swarm optimization (PSO), named as particle swarm fuzzy controller (PSFC). PSO is an optimization method that uses a principle of social behavior of a group of particles. The behaviors are controlled by PSFC to generate individual command action. Later, a context dependent blending (CDB) based on meta fuzzy rules coordinates the commands to produce final control action. The algorithm is validated using parameters of MagellanPro mobile robot and tested by simulation using MATLAB/SIMULINK. Simulation results show that the proposed model offers hopeful advantages and has improved performance
Analysis of polymorphisms in the dopamine beta hydroxylase gene: association with attention deficit hyperactivity disorder in Indian children. (2005)

This is the first molecular genetic study on ADHD in Indian subjects exploring transmission of polymorphisms in the DBH gene. Preliminary investigation shows a trend towards association between the transmission of DBH444a allele and ADHD. No association was noticed between transmission of intron 5 (Taq I) polymorphism and ADHD in the Indian subjects. Presence of strong LD may point towards co-segregation of these two polymorphisms more often than expected.
NEW YORK NEUROLOGICAL SOCIETY (1939)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Archives of Neurology & Psychiatry HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the Archives of Neurology & Psychiatry journal
NEW CO-EDITORS (2007)

I am pleased to announce that Guido Kuersteiner and Robert Taylor have joined the Board of Co-Editors of Econometric Theory for five-year terms beginning on 1 January 2007.
Application and Research of Clickstream Data Analysis Based on Bayes (2008)

Through analysis and research of uncertainty reasoning and Bayes,presents a method that applied subjective Bayes approach in click stream data analysis system.In view of the incomplete information recorded in the Web log,while using subjective Bayes methods of reasoning,it has applied the evidence of the uncertainty to carry on expert evaluations with the conclusions drawn from the subjective Bayes method.It can help to master the degree of attention of the user for the site content and their preferences and interests;also,it can grasp the website's tenacity degree to users,then provide more personalized Web services support for optimizing the website,and provide decision support for further constructions with more attraction.
Downregulation of mi<scp>RNA</scp>‐128 sensitises breast cancer cell to chemodrugs by targeting Bax (2013)

miR-128 is more highly expressed in drug-resistant breast cancer samples than in drug-sensitive samples. We have confirmed that Bax is the target of miR-128 by negative post-transcriptional regulation. miR-128 and Bax were detected in the breast cancer cell line, MDA-MB-231, which was then transfected with miR-128 MIMIC (precursor of miR-128) or AMO (antisense-miR-128 oligonucleotides). After transfection, the chemosensitivity of MDA-MB-231 cell was up-regulated with increasing of Bax and inhibition of miR-128.
[5,6-diaryl-2,3-dihydro-1-pyrrolizinone derivatives synthesis and antiiflammatory and analgesic activities]. (2001)

Compound 3, 8, 11, 14 and 15 showed antiinflammatory activities more potent than ibuprofen. Compound 9, 10 and 11 showed analgesic activities comparable to ibuprofen. These compounds are regarded to be promising to develop new potent drugs.
Cell wall metabolism in fruit softening and quality and its manipulation in transgenic plants. (2001)

Excessive softening is the main factor limiting fruit shelf life and storage. Transgenic plants modified in the expression of cell wall modifying proteins have been used to investigate the role of particular activities in fruit softening during ripening, and in the manufacture of processed fruit products. Transgenic experiments show that polygalacturonase (PG) activity is largely responsible for pectin depolymerization and solubilization, but that PG-mediated pectin depolymerization requires pectin to be de-methyl-esterified by pectin methylesterase (PME), and that the PG beta-subunit protein plays a role in limiting pectin solubilization. Suppression of PG activity only slightly reduces fruit softening (but extends fruit shelf life), suppression of PME activity does not affect firmness during normal ripening, and suppression of beta-subunit protein accumulation increases softening. All these pectin-modifying proteins affect the integrity of the middle lamella, which controls cell-to-cell adhesion and thus influences fruit texture. Diminished accumulation of either PG or PME activity considerably increases the viscosity of tomato juice or paste, which is correlated with reduced polyuronide depolymerization during processing. In contrast, suppression of beta-galactosidase activity early in ripening significantly reduces fruit softening, suggesting that the removal of pectic galactan side-chains is an important factor in the cell wall changes leading to ripening-related firmness loss. Suppression or overexpression of endo-(1-->4)beta-D-glucanase activity has no detectable effect on fruit softening or the depolymerization of matrix glycans, and neither the substrate nor the function for this enzyme has been determined. The role of xyloglucan endotransglycosylase activity in softening is also obscure, and the activity responsible for xyloglucan depolymerization during ripening, a major contributor to softening, has not yet been identified. However, ripening-related expansin protein abundance is directly correlated with fruit softening and has additional indirect effects on pectin depolymerization, showing that this protein is intimately involved in the softening process. Transgenic work has shown that the cell wall changes leading to fruit softening and textural changes are complex, and involve the coordinated and interdependent activities of a range of cell wall-modifying proteins. It is suggested that the cell wall changes caused early in ripening by the activities of some enzymes, notably beta-galactosidase and ripening-related expansin, may restrict or control the activities of other ripening-related enzymes necessary for the fruit softening process.
Broomrape (<i>Orobanche</i> spp.) control with ethylene dibromide and chloropicrin (1988)

Summary: Résumé: Zusammenfassung Ethylene dibromide effectively controlled Orobanche crenata Forsk. and O. cernua Loefl. but was not effective against O. aegyptiaca Pers. and O. mutelii F. Schultz. Chloropicrin was considerably less effective than ethylene dibromide. Mixtures of both compounds did not result in improved broomrape control but nonetheless had a positive effect on crop yield. Destruction des Orobanches avec du dibromure d'ethylène et de la chloropicrine Le dibromure d'éthylène a été efficace contre Orobanche crenata Forsk et O. Cernua Loefl, mais non efficace contre O. aegyptiaca Pers, et O. mutelii F. Schultz. La chloropicrine est beaucoup moins efficace que le dibromure d'ethylène. Les mélanges des deux matières actives n'ont pas amélioré l'efficacité sur orobanches mais néanmoins ont eu un effet positif sur le rendement de la culture. Bekämpfung von Orobanche‐ Arten mit Ethylendi‐bromid und Chlorpikrin Mit Ethylendibromid konnten Orobanche crenata Forsk. und O. cernua Loefl., aber nicht O. aegyptica Pers. und O. mutelii F. Schultz bekämpft werden. Chlorpikrin war beträchtlich weniger wirksam. Mischungen der beiden Wirkstoffe ergaben keine bessere Wirkung, beeinflussten aber den Ertrag der Kulturpflanzen positiv.
An integrated post-locking, multi-versioning, and transformation scheme for consistency maintenance in real-time group editors (2002)

Intention preservation is an important aspect of consistency maintenance in distributed group editors. In this paper, we first introduce a classification framework for various kinds of intentions, then propose LOVOT (post-LOcking, multi-Versioning and Operational Transformation), an integrated scheme for intention preservation. With this scheme, individual users' compatible intentions are preserved by operational transformation, individuals' conflicting intentions are preserved by multi-versioning, and the preservation of a syntactically and semantically consistent group intention is facilitated by post-locking. An algorithm for preserving individual users' intentions is discussed in detail. The integrated scheme is fully distributed, highly responsive, non-blocking and capable of avoiding any locking overhead.
An approach toward profit-driven optimization (2006)

Although optimizations have been applied for a number of years to improve the performance of software, problems with respect to the application of optimizations have not been adequately addressed. For example, in certain circumstances, optimizations may degrade performance. However, there is no efficient way to know when a degradation will occur. In this research, we investigate the profitability of optimizations, which is useful for determining the benefit of applying optimizations. We develop a framework that enables us to predict profitability using analytic models. The profitability of an optimization depends on code context, the particular optimization, and machine resources. Thus, our framework has analytic models for each of these components. As part of the framework, there is also a profitability engine that uses models to predict the profit. In this paper, we target scalar optimizations and, in particular, describe the models for partial redundancy elimination (PRE), loop invariant code motion (LICM), and value numbering (VN). We implemented the framework for predicting the profitability of these optimizations. Based on the predictions, we can selectively apply profitable optimizations. We compared the profit-driven approach with an approach that uses a heuristic in deciding when optimizations should be applied. Our experiments demonstrate that the profitability of scalar optimizations can be accurately predicted by using models. That is, without actually applying a scalar optimization, we can determine if an optimization is beneficial and should be applied.
Rendering for 3D Animation Based on Octree (2010)

In order to improve capability of some traditional algorithms for 3D virtual reality animation, this article comes up with a new improved algorithm, which can improve traditional ones and is more suitable for 3-D graphic environment. There are two steps. The first step is to break down the entire 3-D scene and then setup the Octree structure. The second step is to transform the Octree onto 2-D plane, and write down nodes which are modified and then render the modified ones. Many experiments demonstrate the superiority of the algorithm. Especially, in the process of blanking, the quadrants are shown from far to near and achieve 3-D display more effectively, according to the given object and the location of view.
Adaptive-complexity registration of images (1994)

We present a framework for image registration algorithms that finds a lowest-order model of the flow between two images. Low-order models are useful in image registration, because they leave scene structure intact. But in real images complexity varies, and cannot be determined ahead of time. Algorithms in our framework adapt model complexity to image data during a coarse-fine parameter estimation process. Complexity increases keep residual flow small enough that motion can be correctly estimated at each subsequent resolution level. We present one algorithm within this framework which increases complexity by replacing global estimates with estimates over successively smaller patches. We show results of applying this algorithm to the task of mosaicing panoramic aerial images with unknown lens distortion and unknown camera position.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>