gebhart/patrepeval huggingface dataset:
Changes of the dendritic and transcallosal potentials in local action of high temperature on the cerebral cortex (1977)

<p>Background - Coronary stenting is associated with a restenosis rate of 15% to 20% at 6-month follow-up, despite optimum angiographic stent implantation. In this multicenter registry, we investigated the relation between optimum physiological stent implantation as assessed by poststent fractional flow reserve (FFR) and outcome at 6 months. Methods and Results - In 750 patients, coronary pressure measurement at maximum hyperemia was performed after angiographically apparently satisfactory stent implantation. Poststenting FFR was calculated and related to major adverse events (including need for repeat target vessel revascularization) at 6 months. In 76 patients (10.2%), at least 1 adverse event occurred. Five patients died, 19 experienced myocardial infarction, and 52 underwent at least 1 repeat target vessel revascularization. By multivariate analysis, FFR immediately after stenting was the most significant independent variable related to all types of events. In 36% of the patients, FFR normalized (&gt;0.95), and event rate was 4.9% in that group. In 32% of the patients, poststent FFR was between 0.90 and 0.95, and event rate was 6.2%. In 32% of patients, poststent FFR was &lt;0.90, and event rate was 20.3%. In 6% of the patients, FFR was &lt;0.80, and event rate was 29.5% (P&lt;0.001). Conclusions - FFR after stenting is a strong independent predictor of outcome at 6 months.</p>
Cloning and characterization of a gene (fadR) involved in regulation of fatty acid metabolism in Escherichia coli (1985)

The regulatory gene fadR has been previously characterized by classical genetic means as a diffusible protein which exerts negative control over fatty acid degradation and acetate metabolism. fadR has also been implicated in the regulation of unsaturated fatty acid biosynthesis. To facilitate the identification of the product of the fadR gene and to study the mechanism by which this multifunctional regulatory gene exerts its control, we cloned a segment of DNA containing the fadR gene in the phage vector lambda L47. Subsequent subcloning of a segment of the chromosomal DNA from the lambda fadR+ phage into various plasmid vectors resulted in the isolation of the fadR gene on a 1.3-kilobase-pair HindIII-EcoRV fragment. fadR strains harboring the cloned fadR+ gene showed inducible levels of fatty acid oxidation and crotonase (enoyl-coenzyme A-hydratase, fadB) activity. The cloned gene exerted transcriptional control over beta-galactosidase synthesis in an fadR strain that had a lambda phi (fad-lacZ+) operon fusion. An fadR mutation in fabA(Ts) strains prevents growth at permissive temperatures without unsaturated fatty acid supplementation (Nunn et al., J. Bacteriol. 154:554-560, 1983). Plasmids carrying the fadR+ gene suppress this unsaturated fatty acid auxotrophy in fadR fabA(Ts) strains at the permissive condition. Maxicell analysis identified a 29,000-dalton protein encoded by the 1.3-kilobase fragment which appeared to be associated with functional fadR gene activity.
Efficient Digital Image Authentication and Tamper Localization Technique Using 3Lsb Watermarking (2012)

The authentications of digital images have become the center of attentions for certain group of companies since the number of doctored images increased. Tampering the digital images in a way that it’s impossible to be detected by naked eyes has become easier with development of image editing tools. Digital watermarking can preserve the authentication of digital images. In this paper we proposed an efficient image tamper detection method using 3 LSB (last significant bit) watermarking technique which is able to authenticate the digital image and detect the tamper locations accurately. In the proposed algorithm a 12-bit watermark key will be created from each block of host image which will be embed to last three significant bit of each block. Our proposed method improved tamper detection technique proposed by Prasad’s in sense of tamper detection rate by 40 percent. The experimental result clearly proved the efficiency of our proposed method.
Mg-Ca 합금의 전기화학적 특성에 미치는 Ca 첨가량 및 열처리의 영향 (2004)

【In this study, the influence of heat treatment and Ca contents on the electrochemical behavior was investigated. Mg-Ca alloys, i.e., Mg-0.22wt%Ca, Mg-0.56wt%Ca, Mg-1.31wt%Ca are prepared by ingot metallurgy. As-cast Mg-Ca alloys exhibited better electrochemical properties than pure Mg. Especially, Mg-0.22wt%Ca alloy improves its anode efficiency up to 62% and lowers the OCP up to -1.72VSCE. Microstructure and XRD patterns of Mg-Ca alloys show that additive Ca element is mainly solid-solutioned. While, the others show the microstructure and XRD pattern with large $Mg_2Ca$ at grain boundary. To assess the effect of heat treatment on the as-cast Mg-alloy, the specimens were heat treated at $200^{\circ}C$ for 2 hours under $CO_2$ gas atmosphere. Although corrosion properties of Mg-Ca alloys are somewhat deteriorated by heat treatment at $200^{\circ}C$ Mg-0.22wt%Ca alloy with uniformly distributed nano-sized $Mg_2Ca$ phase in ${\alpha}$ -Mg matrix show still better corrosion properties than pure Mg specimen.】
How Does the Brain Discriminate Familiar and Unfamiliar Faces?: A PET Study of Face Categorical Perception (2001)

Where and how does the brain discriminate familiar and unfamiliar faces? This question has not been answered yet by neuroimaging studies partly because different tasks were performed on familiar and unfamiliar faces, or because familiar faces were associated with semantic and lexical information. Here eight subjects were trained during 3 days with a set of 30 faces. The familiarized faces were morphed with unfamiliar faces. Presented with continua of unfamiliar and familiar faces in a pilot experiment, a group of eight subjects presented a categorical perception of face familiarity: there was a sharp boundary in percentage of familiarity decisions between 40% and 60% faces. In the main experiment, subjects were scanned (PET) on the fourth day (after 3 days of training) in six conditions, all requiring a sex classification task. Completely novel faces (0%) were presented in Condition 1 and familiar faces (100%) in Condition 6, while faces of steps of 20% in the continuum of familiarity were presented in Conditions 2 to 5 (20% to 80%). A principal component analysis (PCA) indicated that most variations in neural responses were related to the dissociation between faces perceived as familiar (60% to 100%) and faces perceived as unfamiliar (0 to 40%). Subtraction analyses did not disclose any increase of activation for faces perceived as familiar while there were large relative increases for faces perceived as unfamiliar in several regions of the right occipito-temporal visual pathway. These changes were all categorical and were observed mainly in the right middle occipital gyrus, the right posterior fusiform gyrus, and the right inferotemporal cortex. These results show that (1) the discrimination between familiar and unfamiliar faces is related to relative increases in the right ventral pathway to unfamiliar/novel faces; (2) familiar and unfamiliar faces are discriminated in an all-or-none fashion rather than proportionally to their resemblance to stored representations; and (3) categorical perception of faces is associated with abrupt changes of brain activity in the regions that discriminate the two extremes of the multidimensional continuum.
Sensitive Immunoassay of a Biomarker Tumor Necrosis Factor-α Based on Poly(guanine)-Functionalized Silica Nanoparticle Label (2006)

A novel electrochemical immunosensor for the detection of tumor necrosis factor-alpha (TNF-alpha) based on poly(guanine)-functionalized silica nanoparticles (NPs) label is presented. The detection of mouse TNF-alpha via immunological reaction is based on a dual signal amplification: (1) a large amount of guanine residues introduced on the electrode surface through sandwich immunoreaction and poly(guanine)-functionalized silica NP label; (2) Ru(bpy)3(2+)-induced catalytic oxidation of guanine, which results in great enhancement of anodic current. The synthesized silica NP conjugates were characterized with atomic force microscopy, X-ray photoelectron spectroscopy, and electrochemistry. These experiments confirmed that poly(guanine) and avidin were immobilized on the surface of silica NPs. The performance of the electrochemical immunosensor was evaluated and some experiment parameters (e.g., concentration of Ru(bpy)3(2+), incubation time of TNF-alpha, etc.) were optimized. The detection limit for TNF-alpha is found to be 5.0 x 10(-11) g mL(-1) (2.0 pM), which corresponds to 60 amol of TNF-alpha in 30 microL of sample. This immunosensor based on the poly(guanine)-functionalized silica NP label offers great promise for rapid, simple, cost-effective analysis of biological samples.
Nuclear Imaging of Prostate Cancer with Gastrin-Releasing-Peptide- Receptor Targeted Radiopharmaceuticals (2008)

Prostate cancer is one of the most common causes of cancer in men. Evaluating the different stages of prostate cancer with conventional imaging techniques still proves difficult. Nuclear imaging might provide a technique that is able to evaluate prostate cancer, but clinical application has been limited due to lack of accuracy of current radiopharmaceuticals. The development of radiopharmaceuticals that can be targeted to specific antigens, overexpressed in prostate cancer, but sparse in normal tissue, is crucial. Peptides are of particular interest because of their favourable characteristics, leading to increased attention for nuclear imaging of the gastrin-releasing-peptide-receptor (GRPR) with radiolabelled bombesin-like peptides. Several derivatives of bombesin and its truncated form have been prepared for imaging with single photon emission computed tomography (SPECT) or positron emission tomography (PET), thereby delivering potent candidates for further clinical evaluation. This article provides an overview of the development and preclinical evaluation of radiolabelled bombesin analogues for in vivo targeting of GRPR in prostate cancer. The effect of the radionuclide, chelator, spacer and unnatural amino acids on affinity, metabolic stability and image quality are discussed, as well as agonistic or antagonistic properties. Potent candidates are proposed based on these selection criteria: (I) high affinity for GRPR, with rapid and specific tumour uptake (II) high hydrophilicity resulting in the preferred renal-urinary mode of excretion and low hepatobiliary excretion, (III) high stability, but relatively rapid clearance from blood. Also, a summary is made of clinical studies that report on the detection of prostate cancer with GRPR targeted radiopharmaceuticals.
Sumoylation in gene regulation, human disease, and therapeutic action (2013)

Similar to ubiquitination, sumoylation covalently attaches a small ubiquitin-like modifier (SUMO) protein (92-97 amino acids) to the ε-amino group of a lysine residue. This is quite different from the classically defined post-translational modifications, such as phosphorylation, acetylation, and methylation, which typically add a small chemical group to the targeted residue. Sumoylation has been well studied at the molecular and cellular levels, focusing mostly on site-specific conjugation of human SUMO1, SUMO2, and SUMO3, as well as their homologues in various species. In this short review, we will discuss some recent examples to highlight (a) emerging trends about the coordinated regulation of sumoylation and other post-translational modifications in modulating the function of some transcription factors and pathway-specific regulators, (b) diverse roles of sumoylation in gene regulation implicated in stem cells and different pathogenic conditions, and (c) potential therapeutic strategies related to some of the diseases stated above.
AIDS Vaccine Still Alive as Booster After Second Failure in Thailand (2003)

An experimental AIDS vaccine tested in Thai heroin users has failed to stop the spread of HIV. It's the second time the vaccine, a genetically engineered version of the HIV surface protein gp120 developed by VaxGen of Brisbane, California, has proven ineffective in an efficacy trial. But although gp120 clearly does not work by itself, an ambitious new study in Thailand has just started to assess whether it might provide an effective boost to another AIDS vaccine.
Effects of Polymer Supports on the Kinetics of Solid-Phase Organic Reactions:  A Comparison of Polystyrene- and TentaGel-Based Resins (1998)

A quantitative comparison of kinetics of seven solid-phase organic reactions on two commonly used resin supports, polystyrene (PS)- and Tentagel (TG)-based resins, is presented. The data we obtained contradict the popular presumption that reactions proceed more rapidly on “solution-like” TG resins. Our results are discussed in terms of a hypothesis in which the resin bead is viewed as another “solvent phase”. The effect of polymer backbones on the reaction kinetics is similar to the effect of solvent on a solution reaction rate. There is no single polymer support that favors all reactions. Depending on the nature of a chosen reaction, TG- or PS-based resins can be a better choice for solid-phase organic synthesis.
Composite grid generation code for general 3-D regions - The EAGLE code (1988)

A three-dimensional grid generation code based on a composite block structure is discussed. The code can operate either as an algebraic generation system or as an elliptic generation system. Provision is made for orthogonality at boundaries and complete continuity at block interfaces. The code can operate in two or three dimensions or on a curved surface. The input is structured to be user-oriented, and arbitrary block configurations can be treated.
CCD arrays for readout of electrophotographic latent images (1991)

Arrays of charge sensing elements have been fabricated for nondestructive electronic readout of latent images on electrophotographic materials. The arrays are implemented in the form of a monolithic integrated circuit in which each sensing element is a 5- mu m *5- mu m MOS capacitor; 2048 such elements are arranged in a linear format with effective 5- mu m element-to-element pitch. On-chip circuitry allows for multiple sampling at each sensing site for enhancing signal-to-noise ratio. The resulting signals from the sense elements are multiplexed onto charge-coupled-device (CCD) shift registers for high-speed serial readout. To allow for the small sensor-to-film gap (on the order of 10 mu m) required for capacitive sensing, the chip's bond pads are recessed in deep grooves below the active array surface. The array is packaged within a hydrostatic air bearing which maintains a constant and uniform gap. The response of the array to targets of high spatial frequency recorded on various electrophotographic materials is in excellent agreement with analytical predictions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A context‐aware ubiquitous learning environment for language listening and speaking (2009)

Abstract This paper reported the results of a study that aimed to construct a sensor and handheld augmented reality (AR)‐supported ubiquitous learning (u‐learning) environment called the Handheld English Language Learning Organization (HELLO), which is geared towards enhancing students' language learning. The HELLO integrates sensors, AR, ubiquitous computing and information technologies. It is composed of two subsystems: an English learning management system and a u‐learning tool. In order to evaluate the effects of the proposed learning environment on the learning performance of students, a case study on English learning was conducted on a school campus. The participants included high school teachers and students. A learning course entitled ‘My Campus’ was conducted in the class; it included three activities, namely ‘Campus Environment’, ‘Campus Life’ and ‘Campus Story’. The evaluation results showed that the proposed HELLO and the learning activities could improve the students' English listening and speaking skills.
The clinical significance of local chemotherapies (2002)

This paper discusses differences between statistical and clinical significance. It suggests nine factors to consider when assessing clinical significance of periodontal therapy. The article reviews the multicentre randomized clinical trials on the four antimicrobial local delivery systems commercially available in the USA (tetracycline fibre, chlorhexidine chip, doxycycline gel and minocycline microspheres) and assesses their data in relation to the nine factors for clinical significance. Data from longitudinal studies comparing periodontal surgery to non-surgery were evaluated in a similar fashion to provide a frame of reference. It was concluded that the local delivery of an antimicrobial offers the clinician a statistically and clinically significant option in the treatment of chronic periodontitis. It is not an 'either/or' situation in selecting therapeutic methods. It is a choice of which treatment method works best for that patient by that clinician.
Security in Health Information Systems: An Exploratory Comparison of U.S. and Swiss Hospitals (2009)

Various reports of information security breaches, unintended information disclosures of confidential patient information, and computer attacks have raised the awareness about security issues of health information systems (HIS). This paper explores the interrelation between the use of information systems and information system security in the hospital sector of the Health Industry. It analyzes organizational, regulatory, and technological factors as well as difficulties inherent to health care organizations such as patient safety concerns and the use of these systems by clinicians who rely on timely and correct clinical information about their patients. Technical and organizational security capabilities are discussed with reference to case studies of two academic medical centers and two hospital groups in the United States and Switzerland. It is shown how the practicability of information security controls is limited by the heterogeneous and decentralized nature of HIS and the way in which clinicians use them.
Linked lowstand delta to basin-floor fan deposition, offshore Indonesia: An analog for deep-water reservoir systems (2004)

In offshore East Kalimantan, Indonesia, three-dimensional seismic reflectors can be traced downslope from a lowstand delta to a basin-floor fan, giving insight into depositional processes controlling the distribution of sands that serve as hydrocarbon reservoirs in many ancient deep-water settings. The studied interval includes the last three Pleistocene cycles (10–330 ka; each 110 k.y. in duration). Cycles on the shelf are dominated by progradational packages deposited during highstands and falling eustatic sea level. Progradational packages are separated by parallel reflectors and carbonate buildups of the transgressive systems tracts. During the last two lowstands of sea level (18 and 130 ka), coarse clastics were not deposited in deep-water environments because growth faults and regional subsidence prevented lowstand deltas from reaching the slope. During the lowstand of sea level that ended at about 240 ka, a delta prograded over the previous shelf edge, and sand-rich sediments spilled onto the slope.Strata on the slope and basin floor show how a deep-water depositional system evolved during a single cycle of eustatic sea level. A canyon on the slope connects the 240-ka lowstand delta to a coeval basin-floor fan. The canyon has a sinuous, bipartite fill that consists of a lower, amalgamated channel complex and an upper channel-levee complex. The basin-floor fan formed at the toe of the slope also has two parts. The stratigraphically lower part of the basin-floor fan has broad lobes with relatively continuous reflectors. The stratigraphically higher part has a sinuous channel-levee complex that prograded over the lower fan and fed sheetlike lobes on the outermost fan. The amalgamated channel fills on the slope and sheetlike lobes on the basin-floor fan have moderate- to high-amplitude reflectors and are inferred to represent sand-rich, early lowstand deposits. The channel-levee complexes on the slope and basin floor are dominated by low-amplitude reflectors and are inferred to be mud-rich strata deposited during the late lowstand. Unlike classic sequence-stratigraphic models, these lowstand strata do not onlap the slope; instead, deep-water clastics extend from the last clinoforms of lowstand deltas. In this system, lowstand deltas determined when and where sand-rich sediments entered preexisting canyons on the slope to feed basin-floor fans.
MMA bulk polymerization and its influence on <i>in situ</i> resin viscosity comparing several chemorheological models (2010)

Abstract Earlier published rheological data of methyl methacrylate (MMA) heated and isothermally polymerized at temperatures between 50 and 80°C have been reanalyzed using three semiempirical models of viscosity advancement including a modified Boltzmann sigmoidal model, a microgel model for cure, and a first‐order isothermal kinetic model. These alternative models possessed few fitting parameters and could be used without requiring more experiments to be run. For each dataset as a function of temperature, the analysis resolved time constants associated with both the induction time for polymerization and the rate of viscosity rise, which were inversely related to the polymerization temperature. We found the sigmoidal model the most robust to accommodate nonlinearities in viscosity advancement with radical polymerization of MMA. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
A Review of Biological Aerated Filters (BAFs) for Wastewater Treatment (1999)

Biological aerated filters (BAFs) can combine ammonia, carbonaceous matter, and solids removal in a single-unit process. Biological nutrient removal (N and P) can also be accomplished. Removal rates based on reactor volume for carbonaceous BOD, ammonia, and nitrates of up to 4.1 kg BOD m−3 day−1, 1.27 kg NH3-N m−3 day−1 and 5 kg NO3-N m−3 day−1, respectively, are normally reported. The small footprint and adaptability of BAFs allows them to be used in upgrading established works, especially those in built up areas where space is at a premium. Although many configurations are available, including upflow and downflow, sunken, and floating media, the process still requires some optimization, especially with regard to media type, backwashing rates, and aeration control to decrease power consumption. Key words: biological aerated filter; wastewater treatment; submerged media bioreactor; carbonaceous matter removal; nitrification
Prevalence and correlation of urinary incontinence and overactive bladder in Taiwanese women (2003)

The prevalence of urinary incontinence and overactive bladder in Taiwanese women is similar to that of Western women.
Holism: some reasons for buyer's remorse (1999)

Journal Article Holism: some reasons for buyer's remorse Get access Jonathan Cohen Jonathan Cohen Rutgers University New Brunswick,NJ 08901, USAjoncohen@ruccs.rutgers.edu Search for other works by this author on: Oxford Academic Google Scholar Analysis, Volume 59, Issue 2, April 1999, Pages 63–71, https://doi.org/10.1093/analys/59.2.63 Published: 01 April 1999