gebhart/patrepeval huggingface dataset:
Evidence for a Noncatalytic Carrier Protein in Cholesterol Biosynthesis (1971)

Abstract A requirement for the 105,000 x g supernatant of rat liver (S105) is demonstrated for five different reactions in cholesterol biosynthesis. This is best delinated using a buffer-washed acetone powder of liver microsomes. Incubation of S105 alone with each substrate yields chemically unchanged substrate. Evidence that S105 contains a protein responsible for this requirement includes the observations that it is nondialyzable, heat-labile, and destroyed by trypsin. Chromatography of S105 on Sephadex G-75 yields a protein peak which travels at the void volume and has associated with it both endogenous cholesterol and the ability to stimulate sterol synthesis as assayed in the conversion of Δ7-cholestenol to Δ5,7-cholestadienol. In addition, virtually all of the cholesterol present in the 105,000 x g supernatant of liver is bound to protein. These results plus other observations support the following hypothesis. S105 contains a noncatalytic carrier protein (STEROL CARRIER PROTEIN) which originates from the endoplasmic reticulum, binds the substrate, and makes the substrate reactive to the sterol-synthesizing enzymes present in the acetone powder of liver microsomes. The participation of Sterol Carrier Protein (SCP) may be of key importance in the understanding of the enzymatic synthesis of cholesterol.
A near zero current switching series resonant inverter using GTOs (2003)

The authors present a novel implementation of fast gate turn-off thyristors (GTOs) for a series resonant converter operating above 10 kHz and at an output power rating of 10 kW or greater. A zero current switching gating strategy that eliminates the need of large negative gate drive circuits is presented. This permits the operation of the converter at a near unity load power factor independent of the operating frequency. Consequently, for a given output power, the installed kVA capacity of the converter is minimized, and the system simplicity is maintained. A simplified analysis and component ratings for the GTO-based converter are presented. All the results were verified experimentally.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ANALYSIS OF RESIDENTIAL CHOICE BEHAVIOR BASED ON CLASSIFICATION OF RESIDENTIAL PREFERENCE (2011)

持続可能な社会の実現に向けた都市構造の再構築において住民の選好を反映していくために，住民選好を考慮した居住地選択行動の解析を行った．宇都宮都市圏に住む10年以内に移転を行った人を対象にアンケート調査を行い，選好の多様性及び特徴を分析した．まず，居住地属性26項目について移転時における重視尺度を尋ねる質問の回答結果に因子分析を使い，居住地属性選好因子を3因子抽出した．そしてこの因子得点にクラスタ分析をかけることで，同質な居住地選好を持つ6つのグループに類型化を行った．続いて各クラスタの移転傾向や，クラスタに属する人の特徴の分析を行った．さらにコンジョイント分析によって，代表的な7つの居住地属性について定量的な解析を行い，クラスタ間で特徴の比較を行った．
Noise Characteristics of Combustion Augmented Jets at Midsubsonic Speeds (1974)

Noise generation by a subsonic flow discharging from a combustion chamber is examined with regard to the relative importance of combustion as a source of noise in such a flow system. Measurements of pressure fluctuations inside the combustor are compared with far-field noise measurements by direct cross-correlations. The cross-correlations and derived cross-spectral densities verify that much of the noise originates inside the combustor. A fluid mechanic perturbation model is used to predict exit plane velocity fluctuations due to internal pressure fluctuations. This unsteadiness at the exit plane is assumed to behave as an acoustic monopole which radiates to the far field. Far-field noise levels estimated on this basis are in good agreement with measured values. The over-all noise level from the combustor/jet is found to be 10-20 db higher than for an equivalent clean, cold jet at the same exit velocity, in the range of 500-700 fps.
A new two-stage Op-Amp using gate-driven, and positive feedback techniques (2010)

This paper describes the design and simulation of a new high-gain, low-power two-stage Op-Amp in a 0.18 μm CMOS technology. Using both the gate-driven transistor and positive feedback concepts, the DC-gain of the conventional two-stage Op-Amp is increased about 20 dB while power dissipation is approximately unchanged. Both the analytical and simulation results show that although the DC-gain will increase about 20 dB but no significant change will be made in the unity-gain bandwidth of the circuit. Besides, the settling behavior of the proposed circuit is verified by employing the Op-Amp in a flip-around sample-and-hold. It is shown that the proposed Op-Amp has better settling behavior than its conventional counterpart.
Pharmacological characterization of nociceptin receptor: an in vitro study (1997)

The newly discovered neuropeptide nociceptin (NC) (alias orphanin FQ) was tested for its potential direct effects as well as for its ability to modify the electrically evoked contractions in several isolated organs suspended in vitro. NC was inactive both as stimulant and as inhibitor of smooth muscle in several preparations, whereas it inhibited the contractions induced by electrical field stimulation in the mouse vas deferens and guinea pig ileum. NC showed the same potency (IC50 = 10 nM) in the two preparations. However, it was significantly more effective in the mouse vas deferens (maximal effect -80%) than in the guinea pig ileum (maximal effect -50%). The inhibitory effect exerted by NC in the two preparations was not affected by naloxone or more selective opioid receptor antagonists. Moreover, by truncation of C-terminal sequences, NC fragments were designed. These fragments were subsequently tested in the mouse vas deferens and in the guinea pig ileum: NC(1-13)-NH2 was the smallest peptide maintaining the same efficacy and potency as the natural peptide. Finally, NC-NH2 and its fragments NC(1-13)-NH2 and NC(1-9)-NH2 were modified by substituting the phenylalanine 1 residue with a tyrosine. These peptides were tested in the guinea pig ileum, where they behaved as mixed NC-opioid receptor agonists ([Tyr1]NC-NH2 and [Tyr1]NC(1-13)-NH2) or as pure opioid receptor agonists ([Tyr1]NC(1-9)-NH2. In conclusion, the present paper demonstrated that the electrically stimulated mouse vas deferens and guinea pig ileum can be used as a sensitive bioassay for studying the pharmacology of NC and related compounds.
Ce<sup>4+</sup>: a New Etching Agent for Cadmium Telluride (1995)

Cadmium telluride (CdTe) has been etched for the first time in a 2M H 2 SO 4 solution in the presence of Ce 4+ . The etching rates have been obtained by means of step measurements. They are proportional to the Ce 4+ concentration and to the dipping time and are close to etching rates obtained for III-V compounds under the same conditions. The etching rates show no decrease with time in the concentration range studied ( 10 -4 M-10 -1 M) even for large steps (several µ m). Etching rates up to 0.1 µ m/min have been obtained, which can be increased by a factor of about 10 by ultrasonication. The evolution of composition of the sample surface has been investigated by means of X-ray photoelectron spectroscopy (XPS) analysis. Elemental tellurium-rich, oxide-free surfaces are obtained after etching in the presence of Ce 4+ .
Acoustical Investigations of a La[sub 0.75]Sr[sub 0.25]MnO[sub 3] Single Crystal (2005)

The acoustical, resistive, and magnetic properties of a La0.75Sr0.25MnO3 lanthanum manganite single crystal are investigated in the temperature range involving the second-order magnetic phase transition. The acoustical measurements are performed by the pulse-echo method in the frequency range 14–90 MHz. It is found that, as the temperature decreases, the velocity of a longitudinal acoustic wave propagating along the [111] axis in the single crystal drastically increases at temperatures below the critical point of the magnetic phase transition. No dispersion of the acoustic velocity is revealed. A sharp increase in the acoustic velocity is accompanied by the appearance of an acoustical absorption peak. The observed effects are discussed with due regard for the interaction of acoustic waves with the magnetic moments of the manganese ions.
Induction of Golli-MBP Expression in CNS Macrophages During Acute LPS-Induced CNS Inflammation and Experimental Autoimmune Encephalomyelitis (EAE) (2007)

Microglia are the tissue macrophages of the CNS. Microglial activation coupled with macrophage infiltration is a common feature of many classic neurodegenerative disorders. The absence of cell-type specific markers has confounded and complicated the analysis of cell-type specific contributions toward the onset, progression, and remission of neurodegeneration. Molecular screens comparing gene expression in cultured microglia and macrophages identified Golli-myelin basic protein (MBP) as a candidate molecule enriched in peripheral macrophages. In situ hybridization analysis of LPS/IFNg and experimental autoimmune encephalomyelitis (EAE)-induced CNS inflammation revealed that only a subset of CNS macrophages express Golli-MBP. Interestingly, the location and morphology of Golli-MBP+ CNS macrophages differs between these two models of CNS inflammation. These data demonstrate the difficulties of extending in vitro observations to in vivo biology and concretely illustrate the complex heterogeneity of macrophage activation states present in region- and stage-specific phases of CNS inflammation. Taken altogether, these are consistent with the emerging picture that the phenotype of CNS macrophages is actively defined by their molecular interactions with the CNS microenvironment.
Organized molecular systems in structured non-aqueous solvents. Is formamide a water like solvent? (2008)

We have investigated the aggregation of surfactants in formamide (FA) instead of water. Qualitatively, the general behavior with FA is similar to the corresponding aqueous systems. Micelle formation has been demonstrated in this solvent as well as the formation of liquid crystalline mesophases at higher surfactant concentration. However, there were some quantitative differences, for example: the much higher Krafft temperature and critical micellar concentration (cmc) values with FA solvent compared to the aqueous systems, and the possibility to utilize amphiphilic molecules insoluble in water. Vesicles and liposomes have been observed, similar to those obtained in water. Also, in microemulsions, water may be replaced by formamide and such non-aqueous microemulsions are reaction media very efficient for organic synthetic processes.
A reflection-absorptive harmonic-rejection filter for RF power amplifiers (2010)

A novel reflection-absorptive harmonic-rejection filter (RA-HRF) is presented for harmonic-terminated high-efficiency RF power amplifier (PA). It basically consists of a pair of reactive band-rejection filter and a dual-band Wilkinson power divider where its isolation resistor absorbs the reflected signals from the band-rejection filters. The reflection-absorptive property can solve a parasitic anti-resonance problem between a harmonic-rejection filter and a harmonic termination circuit in a PA, which degrades the efficiency/attenuation of the PA/filter. Furthermore, the proposed RA-HRF has a low-loss property because of its structural symmetry and simplicity, compared with other conventional resistive/balanced reflection-absorptive filters. A Ku-band RA-HRF for suppressing 2nd-harmonic of an X-band PA has been fabricated, and the reflection-absorptive/low-loss characteristics have been confirmed experimentally.
Decentralized algorithms and architecture for tracking and identification (2002)

Present two algorithms for tracking and identification in decentralized multi-sensor systems. Decentralized architectures have many benefits in terms of modularity, speed and robustness. The state estimation (tracking) algorithm is a decentralized Kalman filter (DKF) based on the extended Kalman filter. Identification is achieved by the decentralized Bayesian identification (DBI) algorithm, which identifies targets being tracked. For each of the algorithms The authors discuss optimality and the effect of reducing connectivity. The structure of the algorithms leads to the development of an architecture for a modular sensing node based on communication considerations. The authors present example implementations of both algorithms on actual transputer-based sensing nodes. They describe RCD (region of constant depth) tracking and for this develop a monopulse sonar arrangement with which they implement real-time autonomous tracking by a single sensor node. The second example implementation describes identification of targets being tracked by the DKF using the DBI on actual CCD camera-based nodes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Facile reaction of organoboranes with methyl vinyl ketone. Convenient new ketone synthesis via hydroboration (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile reaction of organoboranes with methyl vinyl ketone. Convenient new ketone synthesis via hydroborationAkira. Suzuki, Akira. Arase, Hachiro. Matsumoto, Mitsuomi. Itoh, Herbert Charles. Brown, Milorad M. Rogic, and Michael W. RathkeCite this: J. Am. Chem. Soc. 1967, 89, 22, 5708–5709Publication Date (Print):October 1, 1967Publication History Published online1 May 2002Published inissue 1 October 1967https://pubs.acs.org/doi/10.1021/ja00998a040https://doi.org/10.1021/ja00998a040research-articleACS PublicationsRequest reuse permissionsArticle Views733Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Determination of Fluoride Content in Cheese by a Microdiffusion Method (1966)

A simple method has been developed for determination of fluoride in cheese. It consists of ashing a cheese sample in the presence of magnesium acetat% which converts fluorine into the magnesium salt. The ash is then quantitatively transferred to the sample compartment of a modified Conway microdiffusion cell. Fluoride is liberated as ]IF upon mixing with sulfuric acid and absorbed by the sodium hydroxide in the center compartment. The soluble sodium fluoride thus formed is determined colorimetrica]ly with a lanthanum-alizarin complexan reagent. Experimental conditions for the quantitative recovery of fluoride in cheese have been established for this method, which can measure up to 40 /~g of fluoride in the cheese sample. The fluoride contents in several Italian cheeses have been analyzed; the average concentration ranges from 4 to 7 ~g of fluoride per gram of dry cheese solids.
An In Vitro Method for Assessing Potential Toxicity of Cosmetic Products (1993)

One difficulty encountered in testing finished cosmetic products arises from their final physical form. The presence of lipid or solid phases in the products makes them incompatible with the currently used cell culture media. In this study we have used a new method that permits the use of the testing materials directly on the cell's monolayer using a cell culture insert (Falcon). This device is characterized by a polycarbonate porous membrane at the bottom of the insert. The insert containing the testing samples is put on top of the well and is then in contact with the medium. In this way we are still able, after the exposure, to evaluate several parameters that are indices of cell injury. We have tested the toxicity induced by four cosmetic emulsion bases using neutral red uptake determination, protein quantification, and lactate dehydrogenase activity on L929 cells. The least toxic emulsion was then used to estimate the toxicity of two commonly used preservatives, methylchloroisothiazolin-1 and methylisothiazoline-1 (Kathon CG) and 2-bromo-2-nitropropane-1,3-diol (Bronopol) at four different concentrations. We found that methylchloroisothiazolin-1 and methylisothiazolin-1 (Kathon CG) show a good dose-response relationship and that 2-bromo-2-nitro-propane-1,3-diol (Bronopol) inhibits neutral red uptake at all the tested concentrations. However, the protein determination performed on the same cells showed no significant difference between the two preservatives used, even if any morphologic changes were evident and the neutral red uptake was almost absent.
Matrix-based discrete event control of automated material handling systems (2006)

This paper describes a matrix-based discrete event control approach for an automated material handling system operating in a warehouse. The proposed approach addresses both low-level hardware synchronization/sequencing, and high-level operational control of rail-guided vehicles by means of an integrated framework based on binary matrices. The paper illustrates how to obtain the model of the entire warehouse by assembling the discrete event models of the atomic components. Once defined, the matrix-based dynamic model can be used for both controller synthesis and detailed discrete-event simulation of the system. In particular, a summary of simulation results obtained for an actual industrial warehouse environment is provided to illustrate the potential of the integrated matrix-based approach on large-scale, challenging automation problems
Determination of the Burgers vector of dislocations in deformed uranium carbide (1966)

Abstract Polycrystalline are cast uranium carbide was strained in compression at 1410°c. After deforming, transverse slices were cut and thinned for examination in the electron microscope. The Burgers vectors of the deformation dislocations were found to be of the type α/2 〈110〉.
Vanadium Dioxide Huygens Source Metasurfaces as Environment-Sensitive Optical Modulators (2017)

Dielectric Huygens source metasurfaces provide a platform for dynamic optical tunability through modulation of material or geometric properties with potential in sensing applications. Simulated amplitude modulation of >85%; experimental realization in progress.
ChemInform Abstract: Iterative Divergent/Convergent Approach to Linear Conjugated Oligomers by Successive Doubling of the Molecular Length: A Rapid Route to a 128 Å Long Potential Molecular Wire. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hodgkin's Disease (2005)

This chapter contains sections titled: Incidence and Epidemiology Aetiology Pathology Abnormal Immunity in Hodgkin's Disease Clinical Features Patterns of Spread Staging Classification Investigation Percutaneous Biopsy Staging Laparotomy and Splenectomy Treatment Management as Determined by Stage Hodgkin's Disease in Childhood Hodgkin's Disease during Pregnancy Toxicity of Treatment Second Malignancies References
Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnancy and GDM. (2000)

The cellular mechanisms for the insulin resistance of pregnancy and gestational diabetes mellitus (GDM) are unknown. The membrane protein plasma cell membrane glycoprotein-1 (PC-1) has been identified as an inhibitor of insulin receptor tyrosine kinase (IRTK) activity. We investigated insulin receptor function and PC-1 levels in muscle from three groups of obese subjects: women with GDM, pregnant women with normal glucose tolerance, and nonpregnant control subjects. Subjects (n = 6 for each group) were similar in age and degree of obesity (body fat >30%). IRTK activity, insulin receptor tyrosine phosphorylation, and protein levels of membrane glycoprotein PC-1 were determined in rectus abdominus muscle biopsies obtained at the time of either elective cesarean section or gynecological surgery. No significant differences were evident in basal insulin receptor tyrosine phosphorylation or IRTK activity in the three groups. After maximal insulin (10(-7) mol/l) stimulation, IRTK activity measured with the artificial substrate poly(Glu,Tyr) increased in all subjects but was lower in women with GDM by 25% (P < 0.05) and 39% (P < 0.001) compared with pregnant and nonpregnant control subjects, respectively. Similarly, insulin receptor tyrosine phosphorylation was significantly decreased in subjects with GDM (P < 0.05) compared with pregnant and nonpregnant control subjects. Treatment of the insulin receptors with alkaline phosphatase to dephosphorylate serine/threonine residues increased insulin-stimulated IRTK activity significantly in pregnant control and GDM subjects (P < 0.05), but these rates were still lower compared with nonpregnant control subjects (P < 0.05). PC-1 content in muscle from GDM subjects was increased by 63% compared with pregnant control subjects (P < 0.05) and by 206% compared with nonpregnant control subjects (P < 0.001). PC-1 content was negatively correlated with insulin receptor phosphorylation (r = -0.55, P < 0.05) and IRTK activity (r = -0.66, P < 0.05). These results indicate that pregnant control and GDM subjects had increased PC-1 content and suggest excessive phosphorylation of serine/threonine residues in muscle insulin receptors and that both may contribute to decreased IRTK activity. These changes worsen in women with GDM when controlling for obesity. These postreceptor defects in insulin signaling may contribute to the pathogenesis of GDM and the increased risk for type 2 diabetes later in life.
Conjugation of LPS-Derived Oligosaccharides to Proteins Using Oxime Chemistry (2011)

Conjugates of bacterial polysaccharides covalently bound to a carrier protein are among licensed human vaccines. Immunization of adults and children with these vaccines results in induction of saccharide-specific antibodies composed mainly of the IgG class. Depending on the choice of coupling technique, saccharides can be attached to a protein by either multiple- or single-point attachments. While the first method is suitable for high molecular mass polysaccharides, the second one is beneficial for low-molecular mass compounds such as synthetic carbohydrates or bacterial oligosaccharides obtained by different degradation procedures. This chapter describes a method for coupling low-molecular mass lipopolysaccharide (LPS)-derived oligosaccharides composed of a core or a short O-specific polysaccharide-core fragment (O-SPC) to a carrier protein by a single-point attachment. Conjugation is performed between the carbonyl group of the reducing terminal of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) exposed after acid hydrolyses of LPS and the aminooxy group of a bifunctional linker bound to the protein. This is an efficient reaction that can be carried out quickly and under mild conditions. Conjugates thus prepared using this approach preserve the external nonreducing end of the sugar chain and can induce antibodies to both conjugate components. Consequently, this method is highly suitable for the preparation of LPS-based human vaccines.