gebhart/patrepeval huggingface dataset:
Low cost Polymer Optical Fibre based transmission system for feeding integrated broadband wireless in-house LANs (2002)

A bi-directional transmission system using low cost Polymer Optical Fibre (POF) to feed the required large number of radio access points in next-generation integrated broadband wireless in-house LANs is proposed. Results from simulations and experiments show that, by tuning system parameters, a large variety of pure microwave carriers exceeding 60 GHz can be generated at the radio access points. Furthermore, the system supports data rates exceeding 100 Mbps using both linear and constant envelope modulation formats such as PSK and x-QAM. The consolidation of costly\nmicrowave signal processing equipment at the headend station leads to simpler remote radio access points resulting in system cost savings.
Room temperature deposited indium zinc oxide thin film transistors (2007)

Depletion-mode indium zinc oxide (IZO) channel thin film transistors were fabricated on glass substrates from layers deposited at room temperature using rf magnetron sputtering. The threshold voltage was in the range from −5.5to−6.5V depending on gate dielectric (SiO2) thickness and the drain current on-to-off ratio was ∼105. The maximum field effect mobility in the channel was ∼4.5cm2V−1s−1, lower than the Hall mobility of ∼17cm2V−1s−1 in the same layers, suggesting a strong influence of scattering due to trapped charges at the SiO2-IZO interface. The low deposition and processing temperatures make these devices suitable for applications requiring flexible substrates.
Microwave absorption and molecular structure in liquids. XL. The dielectric relaxation of a polyester of 1,2‐propylene glycol and adipic acid in solution (1960)

Abstract The dielectric constants and losses have been measured at 20°C. and wavelengths of 1.25, 3.22, 10.0, 25, and 50 cm., and 575 m. for a series of dilute benzene solutions of a polyester of 1,2‐propylene glycol and adipic acid with molecular weight between 5,000 and 7,000. The dielectric constant and loss values are plotted against the weight concentrations of the solute and the slopes of the straight lines thus obtained are examined by four different methods of analysis. The data may be represented in terms of two parameters, a most probable relaxation time and a distribution factor, two relaxation times, or a distribution of relaxation times between two limiting values. The values obtained for the relaxation times are close to those previously found for long‐chain fatty acid esters and correspond to relaxation by twisting of short segments containing carboxy groups around bonds in the chain. A value 1.57 × 10 —18 obtained for the effective dipole moment of the COOC group as compared to 1.9 × 10 —18 in a small monoester indicates some restriction of rotation around the bonds because of mutual repulsion between the polar groups.
Identification of α-fetoprotein producing cells in the early stage of hepatocarcinogenesis with n-2-fluorenylacetamide in rat (1979)

AFPが肝癌細胞の脱分化をしめす指標であれば,肝発癌過程の肝組織におけるAFP産生細胞を明らかにすることは前癌性病変を検索する上で重要である.最近,過形成性結節の他に胆管上皮由来と考えられる,いわゆる卵円形細胞にAFPの局在を認め,この細胞を前癌性病変とする報告がおこなわれているが,著者らの研究ではそのような事実を証明しえず,卵円形細胞の増殖巣にみられる好塩基性の細胞質を有する肝細胞にAFPな証明した.さらに発癌剤を投与することによって生じる過形成性結節に一致してAFPの局在が認められ,既に報告しだ事実な再確認するとともに,過形成性結節細胞の前癌性病変としての意義をさらに強調した.
A Transition‐Metal‐Free Synthesis of Fluorinated Naphthols (2014)

Herein, we describe a transition-metal-free protocol for the conversion of simple 2-allyl-3-(trifluoromethyl)phenols into substituted 5-fluoronaphthalen-1-ols. The key events of this reaction include the selective activation of two C-F bonds and formation of an intermediate hexatriene system, which undergoes a 6π electrocyclization, followed by rearomatization. This concept enables the rapid conversion (three steps) of various commercially available 3-(trifluoromethyl)phenols into novel fluorine-containing naphthols, which are difficult to prepare by previous methods. The reported sequence was also extended to a one-pot transformation of 3-(trifluoromethyl)phenols into 5-fluoronaphthalen-1-ols.
ChemInform Abstract: Crystal Structure and Physical Properties of New Ca<sub>2</sub>TGe<sub>3</sub> (T: Pd and Pt) Germanides. (2016)

Abstract Ca 2 PdGe 3 and Ca 2 PtGe 3 are prepared by arc melting of stoichiometric amounts of Pd or Pt with Ge and subsequent addition of excess Ca (Al 2 O 3 crucible in quartz ampoule, 880 °C, 12 h, ≈50 kPa Ar).
A co-simulation platform for actuator networks (2007)

Actuator networks will enable an unprecedented degree of distributed control of physical environments, and further progress will critically depend on the availability of a simulation platform that can capture both the physical and the communication dynamics.
STUDIES ON THE EXTRACTION OF PENICILLIN (1948)

Principles of the extraction process of penicillin such as the solvent process and the charcoal adsorption process were found before the end of the second world war in Japan (1), but it was since November 1946, when Foster came to Japan, to undertake the systematic studies of the extraction.At about the beginning of our study, the recovery of penicillin from the broth to the packaging in a final container in Japanese factories fluctuated between 10-40%, but now it increased to 50-80%. This increase is completely ascribable to the systematic and elaborate examinations of all the stages in the extraction process, not but to the change of the principles.In the present paper the experiments and results concerning each stage of the extraction are described.
Shortest path discovery of complex networks (2009)

In this Rapid Communication we present an analytic study of sampled networks in the case of some important shortest-path sampling models. We present analytic formulas for the probability of edge discovery in the case of an evolving and a static network model. We also show that the number of discovered edges in a finite network scales much more slowly than predicted by earlier mean-field models. Finally, we calculate the degree distribution of sampled networks and we demonstrate that they are analogous to a destroyed network obtained by randomly removing edges from the original network.
Thermodiffusion in binären Gemischen geschmolzener Salze I. LiNO<sub>3</sub>—AgNO<sub>3</sub> (1962)

Bei Thermodiffusion in Gemischen, wo der Unterschied zwischen den Dichten der beiden Komponenten groß ist, kann der sog. vergessene Effekt ausschlaggebend sein, d. h. die schwere Komponente kann unabhängig von der Richtung des Elementareffektes nach unten angereichert werden. Letzteres kann aber dadurch festgestellt werden, daß ein Isotopieeffekt gleichzeitig mit der Trennung der beiden Komponenten gemessen wird. In einer Konvektionszelle wurde Thermodiffusion in LiNO 3 —AgNO 3 -Gemischen über den Konzentrationsbereich 20—100 Mol-% LiNO 3 bei etwa 300 °C untersucht. Im oberen Teil der Zelle wurde sowohl LiNO 3 als auch das leichte Isotop 6 Li angereichert. Dies bedeutet, daß LiNO 3 gegen die warme Wand wandert.
Surveillance schemes with applications to mass calibration (1993)

7. Computation of limx- 53 1 16 Appendix 8. Diagnostics 17 Appendix 9. Remarks 54 61 11 List of Figures The design of the maiss difference measurements 3 217 estimates in milligrams of weight differences of two standard weights of 1 kilogram each, made at the NIST between 1975 and 1988 4 The Shiryayev-Roberts control chart with stopping threshold A. 10 4 The Shiryayev-Roberts control chart with stopping threshold A = 220 11 5 Parametric surveillance for a change of the mean of the mass difference data; 1 < A^220 = 23 12 Parametric surveillance for a change of the mean of the mass difference data: Rt,l < Nsoo = 40 13 Parametric surveillance for a change of the mean of the mass difference data: Rx,l < ^eooo = 162 14 8 Pairametric surveillance for a change of the mean of the mass difference data: 1 < i < 217 14 9 Nonparametric surveillance for a change of the mean of the mass difference data; R,, 1 < i < N 210 = 42 16 NonpcU'ametric surveillance for a chamge of the mean of the mass difference data; R^,! < i < 161 17 Nonparametric surveillance for a change of the mean of the meiss difference data: Rt,l < i < 217 17 Post-detection parametric analysis of mass difference data; surveillance for a change of mean. ARL to fadse alajm=370, starting anew after each observation, (a) i2t,24 < i < N 220 = 74. (b) R^J5<i< N 220 = 113. (c) 72,, 114 < i < N 220 = 164. ( d) R"165 <x < 217 19 Post-detection nonparametric amalysis of mass data: surveillance for a change of mean. ARL to false alarm=370, starting anew after each observation, (a) 72,, 43 < i < N 210 = 60. (b) 72.. 61 < f < iVjio = 114. (c) 72,, 115 < i < N 210 = 161. ( d) 72.. 162 < i < 217 20 Surveillance segments of mass difference data, bcised on parametric control for change of mean. ARL to false alarm=370. Putative change= 1 standard deviation 21 iii 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Surveillance segments of maiss difference data, based on nonparametric control for change of mean. ARL to false alarm=370
Elctrosyntheses utilisant une anode soluble : etude de la carboxylation d'halogenures organiques et nouvelles applications (1989)

L'emploi d'anodes consommables constituees de metaux facilement oxydables a ete recemment developpe en electrosynthese organique. Cette technique s'applique notamment a la synthese de liaison carbone-carbone par couplage d'une molecule electroreductible avec un reactif electrophile. Nous avons d'une part mis au point de nouvelles applications en synthese grace a cette methode et d'autre part, nous apportons des informations sur les differents processus mis en jeu au cours des electrolyses. Nous avons montre tout d'abord que ce procede est applicable a l'electrocarboxylation d'une grande variete de composes aromatiques chlores. Nous avons ensuite realise l'electrosynthese de molecules fluorees par electroreduction de arcf#3 en presence de divers electrophiles. Pour ces reactions le choix des conditions experimentales et en particulier celui du solvant et de l'anode est important. Nous avons mis en evidence l'intervention de reactions parasites telle la degradation du solvant dmf qui se reduit au contact du magnesium electrodecape. Cette degradation du solvant peut etre a l'origine des problemes rencontres dans certains cas ou l'on observe une passivation irreversible de la cathode. Nous avons montre que des moyens simples permettent d'y remedier. Parmi ces moyens, le plus efficace est la modification de l'etat de surface de la cathode par electrodeposition prealable d'un metal tel le cadmium, le zinc, le plomb ou l'etain. Nous avons demontre en outre que l'utilisation conjointe d'une anode consommable en magnesium et de cathodes ainsi modifiees permet, par electroreduction de derives halogenes dans le seul solvant dmf, d'aboutir aux aldehydes correspondants avec de bons rendements
Device for Cleaning Tissue Around the Superior Mesenteric Artery, from the Viewpoint of the Mode of Invasion in Pancreatic Head Cancer. (1994)

膵頭部領域癌根治手術にあたり上腸間膜動脈神経叢を温存した腸間膜根部リンパ節郭清が可能か否かに関する検討を行った.上腸問膜動脈からリンパ節までの距離は5.5±2.1mmで, 外膜より3mm以内の同心円内に存在するリンパ節は142s (slice) 中9s (6.3%) にすぎなかった.一方, 上腸間膜動脈根部背側で大動脈との間に挟まれた部位や, 上腸間膜動脈から動脈が分岐する部位では, 神経叢内にもリンパ節は存在していた.以上のようにリンパ節の大部分は外側に分布しているので, 神経叢温存下リンパ節郭清は概ね可能であると考えられた.また膵頭部膵管癌切除25例の検討では5mm以下の小リンパ節に転移を多数認めた.さらにリンパ節転移優位な腫瘍と神経叢浸潤優位な腫瘍が存在し, 神経浸潤とリンパ管浸潤とは異なった進展様式をとることが示唆された.浸潤性膵管癌では膵頭後領域浸潤例の72.2%の神経叢浸潤を認めたが, 粘液産生膵癌や嚢胞腺癌には認めなかった.
NADPH‐induced contractions of mouse aorta do not involve NADPH oxidase: A role for P2X receptors (2006)

Reactive oxygen species elicit vascular effects ranging from dilatation due to hydrogen peroxide‐mediated opening of K + channels, to contraction arising from superoxide (O 2 − ) ‐dependent inactivation of endothelium‐derived nitric oxide. Given that NADPH oxidases are major sources of O 2 − in the vascular wall, this study examined the effects of exogenous NADPH, a substrate of these enzymes, on O 2 − generation (lucigenin) and vascular tone (isometric tension) in mouse isolated aortic rings. NADPH caused concentration‐dependent increases in O 2 − generation and vascular tone. However, while oxidised NADP + was unable to support O 2 − production, it was equally as effective as reduced NADPH at stimulating contraction. An NADPH oxidase inhibitor, diphenyleneiodonium, markedly attenuated NADPH‐induced O 2 − production, yet had no effect on contractions to NADPH. In contrast, two P2X receptor antagonists, PPADS and NF023, markedly attenuated both endothelium‐dependent and ‐independent contractions to NADPH, as did the P2X desensitising agent, α,β‐methylene‐ATP. Importantly, α,β‐methylene‐ATP had no effect on O 2 − production induced by NADPH. In conclusion, these findings suggest little role for NADPH oxidase‐derived O 2 − in the contractile effects of NADPH in the mouse aorta. Rather, NADPH acts as an agonist at two P2X receptor populations; one located on the endothelium and the other on smooth muscle layer.
Susceptibility of Tobacco Plant to the Virus Diseases of the Crops and Weeds (1942)

The viruses of 49 species of agricultural crops and weeds were inoculated on the “Bright yellow” tobacco plant by rubbing the leaf with emery, and 15 species among them were proved to be able to infect it. The severest symptoms was observed on it when infected with the virus from tomato, potato, indian corn, radish, cucumber, Clerodendron trichotomum or Commelina bengalensis.In view of these results it may be considered that certain crops and weeds growing in or near tobacco field can carry the virus disease to the tobacco plant. The eradication of such wild host plants may be very important in controlling the virus disease of tobacco plant.
A phase I study of concomitant galinpepimut-s (GPS) in combination with nivolumab (nivo) in patients (pts) with WT1+ ovarian cancer (OC) in second or third remission. (2018)

5553 Background: WT1 is highly expressed in serous ovarian cancer. GPS is WT1-targeting heteroclitic peptide tetravalent non-HLA-restricted vaccine, and has shown promising phase 2 activity in AML, mesothelioma and myeloma. Efficacy of GPS may be enhanced through checkpoint blockade, providing a rationale for combining it with anti-PD1 antibody, nivo. We conducted a phase I study to evaluate the safety and immunogenicity of the combination in WT1+ OC in remission. Methods: Pts with WT1+ OC in ≥2nd remission were enrolled from 06/16-07/2017, and received GPS (800 mcg) x 6 total doses mixed with adjuvant (0.5 ml) and 70 mcg GM-CSF (all s.c. in extremities) and nivo 3 mg/kg IV q2wks over 12 weeks. DLTs were assessed using CTCAE criteria, with detection of > 2/10 DLTs deeming the combination unsafe. Treatment was continued until disease progression or toxicity. Immune responses (IgG & IgM WT1 antibody, T cell assays) induced by the combination were evaluated. The 1-year progression-free survival (PFS) rate, defined as the interval from start of preceding chemo to date of progression or death, is an exploratory objective. Results: n=11; Median age 61 yrs (41-76). 7 pts in 2nd and 4 pts in 3rd remission. 1 DLT (gr 3 myositis with myocarditis post GPS and nivo #2). Most common AEs were Gr ≤2 fatigue and injection site reactions. Immune Response Results: n=9; Serum levels of antigen-specific IgG (against both individual WT1 peptides in GPS and the full-length WT1) significantly increased in 86% of evaluable pts between study wks 6-27. Antigen-specific T cell responses to individual WT1 peptides were observed between 6-15 wks, primarily CD4 and to a smaller extent, CD8 T cells. 1yr PFS rate was 64% in the ITT analysis (7/11) and 70% (7/10) in pts who had > 2 GPS/nivo doses. Conclusions: Administration of GPS in combination with nivo was safe, well tolerated and induced high frequency of T- and B-cell immune responses, warranting further evaluation. The 1yr PFS rate compares favorably to historic rates of approximately 50% in comparable populations. Additional cohorts are planned to receive the current combination along with vaccination against additional tumor-associated antigens. Clinical trial information: NCT02737787.
Posttranslational Protein Modifications in Type 1 Diabetes - Genetic Studies with PCMT1, the Repair Enzyme Protein Isoaspartate Methyltransferase (PIMT) Encoding Gene (2008)

PCMT1 was virtually associated with T1D in groups defined by other risk genes (SUMO4 and HLA). A general association in a not further defined sample of T1D patients was not evident. Verification in a larger population is needed.
Measurement of Reverse Flow Generated at Cold Exit of Vortex Tube (2014)

In order to clarify the structure of the cold flow discharged from the vortex tube (VT), the pressure of the cold flow was measured, and a simple flow visualization technique using a 0.75 mm-diameter needle and an oily paint is made to study the reverse flow at the cold exit. It is clear that a negative pressure and positive pressure region exist at a certain pressure and cold fraction area, and that a reverse flow is observed in the negative pressure region.
SU‐E‐I‐40: Effective Dose Normalized to Dose Length Product for Pediatric and Adult Reference Phantoms in Computed Tomography Examinations (2012)

An updated set of DLP-to-E conversion factors were established based on more realistic human phantoms and provide an improved accuracy to obtain effective dose from DLP for patients undergoing CT examinations.
Removal of arsenic from groundwater using reagent binding/membrane separation (1993)

Abstract A hybrid method incorporating selective polymeric binding and membrane separation was used for the removal of arsenic from contaminated groundwater. Two types of polymers, polyethylenimine (PEI) and poly‐diallyl dimethyl ammonium chloride (DADMAC) and an ultrafiltration membrane were used at various concentrations and pH. Bench‐scale tests demonstrated a high degree of arsenic removal. The retention of arsenic was also determined in the presence of various background salts such as NaCl, NaNO 3 , Na 2 SO 4 , Na 2 CO 3 . Retention was found to depend on the concentration and type of anion present in solution.
Quantification of Aflatoxin-B<sub>1</sub>-<i>N</i><sup>7</sup>-Guanine in Human Urine by High-Performance Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry<sup>1</sup> (2006)

We report validation of the first isotope dilution mass spectrometry method for determination of aflatoxin B(1)-N(7)-guanine (AFB(1)-N(7)-Gua), a major human aflatoxin-DNA adduct that is excreted in the urine. Measurement of urinary AFB(1)-N(7)-Gua, a biomarker of the biologically effective dose following dietary aflatoxin B(1) (AFB(1)) exposure, has helped identify AFB(1) as a risk factor in the development of hepatocellular carcinoma, a common cancer worldwide. Triple-quadrupole mass spectrometry, coupled with the use of a stable isotope-labeled internal standard (AFB(1)-N(7)-(15)N(5)-Gua) and better solid phase extraction and immunoaffinity column chromatography, have enabled us to greatly improve accuracy, precision, specificity, and sensitivity over previously published determinations. The limit of quantitation for AFB(1)-N(7)-Gua was 0.8 pg/20 mL urine (0.07 pg/mg creatinine). The method was validated for accuracy and precision over the range of 0.8-25 pg/20 mL urine, with between-day and within-day reproducibility for analysis of six aliquots of a human urine sample containing 6.0 pg/20 mL measured at <6% coefficient of variation. AFB(1)-N(7)-Gua concentrations were measured in 20 human urine samples collected in a region with known aflatoxin exposure. The mean concentration of AFB(1)-N(7)-Gua, measured in 16/20 urine samples with levels above the method's limit of quantitation, was 2.9 pg/20 mL urine (0.28 pg/mg creatinine) with a range of <0.8-7.2 pg/20 mL urine (0.04-65 pg/mg creatinine). With improved accuracy and precision, this sensitive biomarker for recent human exposure to AFB(1) will be especially useful for measuring the efficacy of planned interventions to reduce aflatoxin-related liver cancer in AFB(1)-exposed populations.
Recombinant Allergens for Pollen Immunotherapy (2013)

Specific immunotherapy (IT) represents the only potentially curative therapeutic intervention of allergic diseases capable of suppressing allergy-associated symptoms not only during treatment, but also after its cessation. Presently, IT is performed with allergen extracts, which represent a heterogeneous mixture of allergenic, as well as nonallergenic, compounds of a given allergen source. To overcome many of the problems associated with extract-based IT, strategies based on the use of recombinant allergens or derivatives thereof have been developed. This review focuses on recombinant technologies to produce allergy therapeuticals, especially for allergies caused by tree, grass and weed pollen, as they are among the most prevalent allergic disorders affecting the population of industrialized societies. The reduction of IgE-binding of recombinant allergen derivatives appears to be mandatory to increase the safety profile of vaccine candidates. Moreover, increased immunogenicity is expected to reduce the dosage regimes of the presently cumbersome treatment. In this regard, it has been convincingly demonstrated in animal models that hypoallergenic molecules can be engineered to harbor inherent antiallergenic immunologic properties. Thus, strategies to modulate the allergenic and immunogenic properties of recombinant allergens will be discussed in detail. In recent years, several successful clinical studies using recombinant wild-type or hypoallergens as active ingredients have been published and, currently, novel treatment forms with higher safety and efficacy profiles are under investigation in clinical trials. These recent developments are summarized and discussed.
Quantitative Determination of Isozymes of Glutamic Oxalacetic Transaminase in Human Serum. (1964)

Three anionic and two cationic isozymes with GOT activity were found in serum from human subjects, and their relative concentrations determined. A specific and quantitative method involving zone electrophoresis in starch gel of serum concentrated against PVP, elution of GOT from the gel, and determination of GOT activity by photometric means is described.
Association between the <i>LRP1B</i> and <i>APOE</i> loci and the development of Parkinson’s disease dementia (2022)

Parkinson's disease is one of the most common age-related neurodegenerative disorders. Although predominantly a motor disorder, cognitive impairment and dementia are important features of Parkinson's disease, particularly in the later stages of the disease. However, the rate of cognitive decline varies among Parkinson's disease patients, and the genetic basis for this heterogeneity is incompletely understood. To explore the genetic factors associated with rate of progression to Parkinson's disease dementia, we performed a genome-wide survival meta-analysis of 3923 clinically diagnosed Parkinson's disease cases of European ancestry from four longitudinal cohorts. In total, 6.7% of individuals with Parkinson's disease developed dementia during study follow-up, on average 4.4 ± 2.4 years from disease diagnosis. We have identified the APOE ε4 allele as a major risk factor for the conversion to Parkinson's disease dementia [hazard ratio = 2.41 (1.94-3.00), P = 2.32 × 10-15], as well as a new locus within the ApoE and APP receptor LRP1B gene [hazard ratio = 3.23 (2.17-4.81), P = 7.07 × 10-09]. In a candidate gene analysis, GBA variants were also identified to be associated with higher risk of progression to dementia [hazard ratio = 2.02 (1.21-3.32), P = 0.007]. CSF biomarker analysis also implicated the amyloid pathway in Parkinson's disease dementia, with significantly reduced levels of amyloid β42 (P = 0.0012) in Parkinson's disease dementia compared to Parkinson's disease without dementia. These results identify a new candidate gene associated with faster conversion to dementia in Parkinson's disease and suggest that amyloid-targeting therapy may have a role in preventing Parkinson's disease dementia.