gebhart/patrepeval huggingface dataset:
Reduction of phase error ghosting artifacts in thin slice fast spin‐echo imaging (1995)

Fast spin-echo (FSE) imaging techniques are very sensitive to the relative phase between the 90 degrees (excitation) RF pulse and the 180 degrees (refocusing) RF pulses. In this paper, it is demonstrated that a phase shift can be created between the excitation and refocusing pulses in such a manner that the received signal is divided into two components of distinctly different phase shifts. The nature of these two components is reviewed. It is demonstrated that ghosting artifacts will occur when images are reconstructed from this received signal. The ghosting is shown to be object dependent. A correction technique is presented which calculates the phase errors among different echoes based on measurements from a single echo train acquired without phase encoding gradients. The results in both phantom and human studies show that this method is capable of reducing the ghosting artifact in thin slice FSE images.
Properties of trypsin inhibitor from winged bean (Psophocarpus tetragonolobus) seed isolated by affinity chromatography (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of trypsin inhibitor from winged bean (Psophocarpus tetragonolobus) seed isolated by affinity chromatographyJones Chan and Benito O. De LumenCite this: J. Agric. Food Chem. 1982, 30, 1, 42–46Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/jf00109a008https://doi.org/10.1021/jf00109a008research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Selective and Benign Synthesis of Functionalized Benzalacetones <i>via</i> Mizoroki–Heck Reaction Using Aryldiazonium Salts (2010)

Abstract Palladium‐catalyzed Mizoroki–Heck reactions were carried out in the presence of calcium carbonate in alcoholic solvents. Under these conditions an efficient preparation of functionalized benzalacetones was developed. The reactions were carried out at room temperature and aerobic conditions, giving the products within several minutes in up to 95% isolated yields. Furthermore, some kinetic investigations, mechanistic insights and considerations are presented.
Leisure Time Physical Activity and Mortality (2015)

Meeting the 2008 Physical Activity Guidelines for Americans minimum by either moderate- or vigorous-intensity activities was associated with nearly the maximum longevity benefit. We observed a benefit threshold at approximately 3 to 5 times the recommended leisure time physical activity minimum and no excess risk at 10 or more times the minimum. In regard to mortality, health care professionals should encourage inactive adults to perform leisure time physical activity and do not need to discourage adults who already participate in high-activity levels.
Golden retriever cystic uveal disease: a longitudinal study of iridociliary cysts, pigmentary uveitis, and pigmentary/cystic glaucoma over a decade in western Canada (2015)

Thin-walled iridociliary cysts are associated with PU and PCG. All breeding golden retriever dogs should be examined annually by an ophthalmologist. The incidence of this disorder is higher in western Canada than previous reports in North America.
A Heuristic for Mapping Virtual Machines and Links in Emulation Testbeds (2009)

Distributed system emulators provide a paramount platform for testing of network protocols and distributed applications in clusters and networks of workstations. However, to allow testers to benefit from these systems, it is necessary an efficient and automatic mapping of hundreds, or even thousands, of virtual nodes to physical hosts-and the mapping of the virtual links between guests to physical paths in the physical environment. In this paper we present a heuristic to map both virtual machines to hosts and virtual links between virtual machines to paths in the real system. We define the problem we are addressing, present the solution for it and evaluate it in different usage scenarios.
Experimental Evaluation of a 1 kW, Single-Phase, 3-LevelGaN Inverter at Extreme Cold Environments (2016)

Low temperature of operation of power electronics applications enables higher efficiencies and higher reliability. Moreover, combining lower temperature of operation with rapidly maturing wide-band ...
Effect of Pre-treatment by Hydrogen in the Oligonnerization of Propylene over Nickel Oxide-Silica-Alumina (1971)

酸化ニッケルーシリカ-アルミナ触媒に対する水素還元および異種金属イオンの添加が,プロピレンの重合活性と生成重合油成分にいかなる影響を与えるかについて研究した。450℃時間の水素還元により,いずれのニッケル組成の触媒の場合も重合活性は著しく低下した。また,水素還元により生成重合油中のC6留分中のn-ヘキセン類およびジメチルブテン-2は著しく減少したが4-メチルペンテン類は増加した。一方,Li20またはIn203の添加によってその重合活性は無添加触媒に比べてそれぞれ著しく増加,または減少した。これらの結果から上記の反応に対する酸化ニッケルーシリカ-アルミナ触媒上の活性点の一つは,触媒表面の正孔であることを結論した。
A Greek Adventure (2011)

'ESPE - The First 50 Years' tells the story of ESPE's development from a small club of friends into an international scientific society. The European Society for Paediatric Endocrinology looks back on its history, major steps in the development of this new subspecialty, and how the 30 founders and the generations of scientists who followed them achieved a democratically structured professional organisation. Success in obtaining vital long-term sponsorship from the industry enabled the development of various high-level educational programmes, fellowships, postgraduate schools, international research clusters and the establishment of prestigious scientific awards. In the second part of the book 21 senior ESPE members look back in personal recollections, and tell fascinating stories of their ESPE past. The third part provides a chronological overview with key data, including the most important scientific topics at ESPE's 50 annual meetings to date, eight of which were international Joint Meetings. These reference overviews of meetings illustrate in detail the impressive development of paediatric endocrinology in Europe and around the world.
Nouveau concept d'élaboration de matériaux carbonés poreux : la synthèse par réplique. (2006)

National audience
Newly Designed Silica‐Containing Redox Nanoparticles for Oral Delivery of Novel TOP2 Catalytic Inhibitor for Treating Colon Cancer (2017)

Although oral drug delivery is the most common route of drug administration, the conventional polymeric nanocarriers exhibit a low drug loading capacity and low stability in the gastrointestinal (GI) environments. In this study, a newly designed silica-containing redox nanoparticle (siRNP) with reactive oxygen species (ROS) scavenging capacity is developed as an ideal oral nanocarrier for a novel hydrophobic anticancer compound BNS-22 to treat colitis-associated colon cancer in vivo. Crosslinking of silica moieties significantly enhances the stability under acidic conditions and improves BNS-22 loading capacity of siRNP compared to the conventional redox nanoparticle. After oral administration to mice, BNS-22-loaded siRNP (BNS-22@siRNP) remarkably improves bioavailability and colonic tumor distribution of BNS-22. As the result, BNS-22@siRNP significantly inhibits the tumor progression in colitis-associated colon cancer mice compared to other control treatments. It is noteworthy that no systemic absorption of siRNP carrier is observed after oral administration. Interestingly, orally administered BNS-22@siRNP significantly suppresses the adverse effects of BNS-22 owing to its ROS scavenging capacity, and no other noticeable toxicities are observed in mice treated with BNS-22@siRNP although siRNP is localized in the GI tract. Our results indicate that siRNP is a promising oral drug nanocarrier for cancer therapy.
Scroll expander Organic Rankine Cycle (ORC)efficiency boost of biogas engines (2007)

The most common energy application for biogas is on-site power generation using gas engine units. The introduction of a bottoming cycle based on Scroll expander Organic Rankine Cycle (ORC) technology within a biogas plant is of high interest since the excess heat produced by biogas engines can be used to produce additional power. This paper describes the retrofit of a plant consisting of a digester fed with green municipal wastes and two biogas engine units (200kWe each). The waste heat from the cooling jacket of the first biogas unit is used in cogeneration for the fermentation process and also for heating the buildings of the facility. The objective of the retrofit project is, in a first step, to convert the excess heat from the cooling jacket of the second biogas unit by means of Organic Rankine cycles. Onsite preliminary tests from the operation of the 7 kWe unit have been done, allowing performances to be measured over a broad range of conditions. Those tests confirmed a reasonable behavior of the ORC scroll expander and the interest of the concept. The measured efficiency of the ORC is about 7% with a heat source at around 90°C (i.e. 40% exergy efficiency).
Comparative Oxidation and Net Emissions of Methane and Selected Non-Methane Organic Compounds in Landfill Cover Soils (2003)

The surface emissions of methane (CH4) and non-methane organic compounds (NMOCs) were determined at two different areas at a French landfill: a permanently covered and fully vegetated area (40 cm coarse sand + 80 cm of loam) and a temporarily covered area (40 cm of coarse sand). The 37 NMOCs quantified in the landfill gas samples included alkanes (C1-C10), alkenes (C1-C4), halogenated hydrocarbons (including (H)CFCs), and aromatic hydrocarbons. Both positive and negative CH4 fluxes ranging from -0.01 to 0.008 g m(-2) d(-1) were measured from the permanently covered cell. However, high spatial variation was observed, and a hot spot with a high flux (10 g m(-2) d(-1)) was identified. A higher CH4 emission occurred from the temporarily covered cell (CH4 flux of 49.9 g m(-2) d(-1)) as compared to the permanently covered cell. The NMOC fluxes from the permanently covered zone were all very small with both positive and negative fluxes in the order of 10(-7) to 10(-5) g m(-2) d(-1). Higher and mainly positive NMOC fluxes in the order of 10(-5) to 10(-4) g m(-2) d(-1) were obtained from the temporarily covered zone. The lower emission from the permanently covered and fully vegetated cell was attributable to the thicker soil layer, which functions as microbial habitat for methanotrophic bacteria. The NMOC oxidation capacity was investigated in soil microcosms incubated with CH4. Maximal oxidation rates for the halogenated aliphatic compounds varied between 0.06 and 8.56 microg (g of soil)(-1) d(-1). Fully substituted hydrocarbons (tetrachloromethane, perchloroethylene, CFC-11, CFC-12, and CFC-113) were not degraded in the presence of CH4 and O2. Benzene and toluene were rapidly degraded, giving very high maximal oxidation rates (28 and 39 microg (g of soil)(-1) d(-1)). On the basis of the emission measurements and the batch experiments conducted, a general pattern was observed between emissions and biodegradability of various NMOCs. The emissions mainly consisted of compounds that were not degradable or slowly degradable, while an uptake of easily degradable compounds was registered. As an example, perchloroethylene, trichloromethane, CFC-11, and CFC-12 were emitted, while atmospheric consumption of aromatic hydrocarbons and lower chlorinated hydrocarbons such as vinyl chloride, dichloromethane, and chloromethane was observed. This study demonstrates that landfill soil covers show a significant potential for CH4 oxidation and co-oxidation of NMOCs. Under certain conditions, landfills may even function as sinks for CH4 and selected NMOCs, like aromatic hydrocarbons and lower chlorinated compounds.
The C-terminal Tails of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas Receptors Have Opposing Functions in Fas-associated Death Domain (FADD) Recruitment and Can Regulate Agonist-specific Mechanisms of Receptor Activation (2004)

Members of the tumor necrosis factor (TNF) superfamily of receptors such as Fas/CD95 and the TNF-related apoptosis-inducing ligand (TRAIL) receptors DR4 and DR5 induce apoptosis by recruiting adaptor molecules and caspases. The central adaptor molecule for these receptors is a death domain-containing protein, FADD, which binds to the activated receptor via death domain-death domain interactions. Here, we show that in addition to the death domain, the C-terminal tails of DR4 and DR5 positively regulate FADD binding, caspase activation and apoptosis. In contrast, the corresponding region in the Fas receptor has the opposite effect and inhibits binding to the receptor death domain. Replacement of wild-type or mutant DR5 molecules into DR5-deficient BJAB cells indicates that some agonistic antibodies display an absolute requirement for the C-terminal tail for FADD binding and signaling while other antibodies can function in the absence of this mechanism. These data demonstrate that regions outside the death domains of DR4 and DR5 have opposite effects to that of Fas in regulating FADD recruitment and show that different death receptor agonists can use distinct molecular mechanisms to activate signaling from the same receptor.
Basal cell carcinoma with hyaline inclusions. (1989)

A 67-year-old woman had a basal cell carcinoma of the forehead containing numerous hyaline cytoplasmic inclusions. Electron microscopic studies revealed that these inclusions were aggregates of cytoplasmic filaments. Immunohistochemical studies demonstrated reactivity for keratin, vimentin, and smooth-muscle myosin in these structures. Because of potential diagnostic difficulties, the pathologist should be aware of this unusual form of basal cell carcinoma.
The Effect of Cupric Ions on the Indole Reaction for the Determination of Deoxyribonucleic Acid (1968)

Abstract The presence of cupric ions or ferric ions was found to enhance the development of color in the indole reaction for the colorimetric determination of deoxyribonucleic acid. The addition of calcium, cobaltous, magnesium, manganous, nickel, or zinc ions did not produce this effect. In the absence of added cupric ions, the indole reaction gave variable results, and the color developed to less than half of the optimum level. It is recommended that the reaction mixture for this assay include cupric ions at a concentration of 15 µm. Under these conditions, the molar extinction coefficient (based on the molarity of DNA phosphorus) of the colored product at 490 mµ is equal to 15,800 m-1 cm-1. The assay conforms to Beer's law until the concentration of DNA exceeds 25 µg per ml (A1 cm490 mµ = 1.25) in the reaction vessel.
Treatment of Common Low Back Pain: A New Approach to an Old Problem (2014)

Abstract Low back pain is very common, but the pathophysiology is poorly understood. We present a new hypothesis regarding the pathophysiology of common low back pain supported by our flexible endoscopic observations of the epidural cavity (epiduroscopy), anatomic dissection of embalmed and fresh cadavers, and careful review of preexisting information available on the anatomy of the epidural space and neuroforamen. A new approach to the treatment of common low back pain based on the hypothesis was developed and is presented in the case reports of five patients. Treatment focuses on a perichondrium derivative; the peridural membrane, which creates a suprapedicular compartment in the neuroforamen where we hypothesize inflammatory material accumulates. This produces common low back pain by causing inflammation and sensitization of the peridural membrane and periosteum that forms the boundaries of this compartment. Percutaneous Ablation and Curettage and Inferior Foraminotomy (PACIF sm ) aims to destroy the peridural membrane, denervate sensitive structures, and remove inflammatory tissues from the suprapedicular canal. The proposed mechanism of action and safety of PACIF sm is discussed in the context of epidural and neuroforaminal anatomy. As shown by the five case reports, PACIF sm appears to be highly effective and safe, warranting further evaluation.
Lagrangesche Gleichungen (2012)

Wenn Körpersysteme mit vielen Freiheitsgraden untersucht werden müssen, ist eine verallgemeinerte Form von Bewegungsgleichungen vorteilhaft, die über das Konzept der virtuellen Verschiebungen gewonnen werden. Diese Lagrangeschen Bewegungsgleichungen sind im Allgemeinen nichtlineare Differentialgleichungen 2. Ordnung für die zweckmäßigsten Koordinaten des Systems und frei von Reaktionskräften.
Molecular characterization of a monoclonal antibody produced in response to a group C meningococcal polysaccharide peptide mimic (1996)

We have developed a monoclonal antibody, designated anti-anti-Id Ab3-2C4 which reacts with Neisseria meningitidis serogroup C polysaccharide (MCPS). Anti-anti-Id Ab3-2C4 was produced by immunizing Balb/C mice with a peptide mimic of MCPS. This monoclonal antibody reacts with native polysaccharide and its anti-idiotype antibody Ab2-6F9 by ELISA. The synthetic peptide mimic was constructed based on the sequence of the VHCDR3 region of the anti-idiotype Ab2-6F9. We compared the cDNA sequence of Ab3-2C4 to the sequence of idiotype antibody Ab1-1E4 produced in response to native MCPS. The predicted amino acid sequence of the unique VHCDR3 of anti-anti-Id Ab3-2C4 is similar to that of idiotype Ab1-1E4. Also the VHCDR3 of both antibodies is similar to some of the known or suggested carbohydrate binding motifs. A different VH gene family was utilized by Ab3-2C4 than by Ab1-1E4. These results suggest that immunization with the anti-idiotype-derived peptide mimic of the MCPS antigen stimulates the production of antibodies with a binding site structurally related to idiotype antibodies, even though the antibodies Ab1-1E4 and Ab3-2C4 are not related in gene families. Our results support the premise that the use of peptide antigens which are mimics of carbohydrates is an alternate vaccine strategy for polysaccharide antigens and results in an appropriate response.
Evaluation of evacuated blood-collection tubes: effects of three types of polymeric separators on therapeutic drug-monitoring specimens (1993)

The potential of three types of separator materials found in conventional blood-collection tubes for interference in therapeutic drug measurements was assessed. None of the separators (based on acrylic, silicone, or polyester polymers) had any significant effect on the concentrations of seven drugs (theophylline, digoxin, phenytoin, phenobarbital, gentamicin, ethanol, and cyclosporine) in blood specimens that were processed and analyzed promptly. Storage of specimens for 24 h resulted in an average 2.4% increase in theophylline values in specimens collected in tubes with the acrylic separator (P = 0.024); an average 8.1% decrease in phenytoin in specimens collected in tubes with the polyester-based separator (P < 0.001); and an average 4.2% decrease in phenobarbital in specimens collected in tubes with the polyester-based separator (P = 0.02). All other drug concentrations were not significantly affected. A small decrease in phenytoin (7.9%; P < 0.01) was seen when the specimen volume in 7-mL tubes containing polyester-based separator was reduced to 1.0 mL; all other drug concentrations were unaffected by partial filling of tubes. Paired blood specimens from pediatric patients, when collected in plain tubes and tubes containing acrylic separator, yielded no significant differences for theophylline, digoxin, tobramycin, phenytoin, or phenobarbital concentrations. The three commercially available separators had only small effects on therapeutic drug concentrations, and a newly developed separator based on an acrylic resin was suitably inert.
Genome Analysis and the Human X Chromosome (1992)

A unified genetic, physical, and functional map of the human X chromosome is being built through a concerted, international effort. About 40 percent of the 160 million base pairs of the X chromosome DNA have been cloned in overlapping, ordered contigs derived from yeast artificial chromosomes. This rapid progress toward a physical map is accelerating the identification of inherited disease genes, 26 of which are already cloned and more than 50 others regionally localized by linkage analysis. This article summarizes the mapping strategies now used and the impact of genome research on the understanding of X chromosome inactivation and X-linked diseases.
Fecal Chymotroypsin: a Study on Its Diagnostic Value by Comparison with the Secretin-Cholecystokinin Test (1978)

Fecal chymotrypsin (CT) activities were determined in 149 randomly collected fecal specimens of 80 patients in whom the pancreatic function had been tested by a secretin-cholecystokinin test. There was a significant correlation between fecal CT activities and outputs of trypsin (r = 0.3451, p less than 0.01) and amylase (r = 0.3285, p less than 0.01) in duodenal juice. Fecal CT activities were normal in all patients who--based upon enzyme outputs in duodenal juice after stimulation with secretin and CCK/PZ--were classified as 'borderline cases', in most patients with 'low-normal' pancreatic function, and in a significant number of patients with established insufficiency of exocrine pancreas. On the other hand, fecal CT activities were abnormal in patients with severely impaired output of trypsin in duodenal juice, and only 7% of the fecal specimens from patients with established normal function of exocrine pancreas had abnormal low CT activities. It is concluded that the sensitivity of the fecal enzyme method is rather low as compared to the secretin-cholecystokinin test, but that fecal CT determinations give valuable diagnostic information in patients with more pronounced insufficiency of the exocrine pancreas.
ChemInform Abstract: PREPARATIONS AND PROPERTIES OF HIGHER (2(N))PARACYCLOPHANES, CYCLIC OLIGOMERS OF P‐XYLYLENE (1975)

Abstract p‐Xylylendichlorid (I) reagiert mit Tetraphenyläthylen‐natrium nach Wurtz zu einem Gemisch der Oligomeren (II)‐(VI), deren Trennung beschrieben wird.
Compact torsatron reactors (1988)

Low-aspect-ratio torsatron configurations could lead to compact stellarator reactors with R/sub 0/ = 8--11m, roughly one-half to one-third the size of more conventional stellarator reactor designs. Minimum-size torsatron reactors are found using various assumptions. Their size is relatively insensitive to the choice of the conductor parameters and depends mostly on geometrical constraints. The smallest size is obtained by eliminating the tritium breeding blanket under the helical winding on the inboard side and by reducing the radial depth of the superconducting coil. Engineering design issues and reactor performance are examined for three examples to illustrate the feasibility of this approach for compact reactors and for a medium-size (R/sub 0/ approx. = 4 m,/bar a/ /approx lt/ 1 m) copper-coil ignition experiment. 26 refs., 11 figs., 7 tabs.