gebhart/patrepeval huggingface dataset:
Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins (2016)

Refined methods for maintaining specific functions of isolated hepatocytes under xeno-free and chemical defined conditions is of great importance for the development of hepatocyte research and regenerative therapy. Laminins, a large family of heterotrimeric basement membrane adhesion proteins, are highly cell and tissue type specific components of the extracellular matrix and strongly influence the behavior and function of associated cells and/or tissues. However, detailed biological functions of many laminin isoforms are still to be evaluated. In this study, we determined the distribution of laminin isoforms in human liver tissue and isolated primary human hepatocytes by western blot analysis, and investigated the efficacy of different human recombinant laminin isoforms on hepatic functions during culture. Protein expressions of laminin-chain α2, α3, α4, β1, β3, γ1, and γ2 were detected in both isolated human hepatocytes and liver tissue. No α1 and α5 expression could be detected in liver tissue or hepatocytes. Hepatocytes were isolated from five different individual livers, and cultured on human recombinant laminin isoforms -111, -211, -221, -332, -411, -421, -511, and -521 (Biolamina AB), matrigel (extracted from Engelbreth-Holm-Swarm sarcoma), or collagen type IV (Collagen). Hepatocytes cultured on laminin showed characteristic hexagonal shape in a flat cell monolayer. Viability, double stranded DNA concentration, and Ki67 expression for hepatocytes cultured for six days on laminin were comparable to those cultured on EHS and Collagen. Hepatocytes cultured on laminin also displayed production of human albumin, alpha-1-antitrypsin, bile acids, and gene expression of liver-enriched factors, such as hepatocyte nuclear factor 4 alpha, glucose-6-phosphate, cytochrome P450 3A4, and multidrug resistance-associated protein 2. We conclude that all forms of human recombinant laminin tested maintain cell viability and liver-specific functions of primary human hepatocytes, and that recombinant laminin is a promising xeno-free and chemical defined strategy for preservation of hepatocyte specific function in vitro.
Homogénéisation de noyaux magnétiques feuilletés et non linéaires dans les calculs éléments finis temporels (2003)

NUMELEC2003
1A1-E04 Prospects of Research on Musculoskeletal Humanoids (2006)

This paper shows the current status and future prospects of the research on musculoskeletal humanoids. We have been continuously progressing the project of the musculoskeletal flexible-spine humanoid "Kotaro", which was developed for the Prototype Robot Exhibition at the EXPO'05. The improvements include the structures of the muscle unit, the spine and the head, the geometric model in the computer, electric circuits, tension sensors, spherical joint angle sensors, and so on.
LOP36 (2013)

1Hannover Medical School, Plastic, Hand and Reconstructive Surgery, Hannover, Germany 2Hannover Medical School, Plastic, Hand and Reconstructive Surgery, Hannover, Germany
Microsphere resonators: a route to enhanced functionality in planar lightwave circuits (2008)

Microspheres coupled to planar optical waveguides through evanescent field interaction offer compact high-Q resonators combined with a flexible choice of resonator material for lasing, sensing, filtering or all-optical switching devices. Coupling on a planar optical circuit results in robust construction, straightforward alignment of multiple and concatenated resonators, direct access to evanescent fields, high compatibility with optical fiber applications and low cost of fabrication.
Accurate Model for Predicting Adsorption of Olefins and Paraffins on MOFs with Open Metal Sites (2014)

Metal–organic frameworks (MOFs) have shown tremendous potential for challenging gas separation applications, an example of which is the separation of olefins from paraffins. Some of the most promising MOFs show enhanced selectivity for the olefins due to the presence of coordinatively unsaturated metal sites, but accurate predictive models for such systems are still lacking. In this paper, we present results of a combined experimental and theoretical study on adsorption of propane, propylene, ethane, and ethylene in CuBTC, a MOF with open metal sites. We first propose a simple procedure to correct for impurities present in real materials, which in most cases makes experimental data from different sources consistent with each other and with molecular simulation results. By applying a novel molecular modeling approach based on a combination of quantum mechanical density functional theory and classical grand canonical Monte Carlo simulations, we are able to achieve excellent predictions of olefin adsorption, in much better agreement with experiment than traditional, mostly empirical, molecular models. Such an improvement in predictive ability relies on a correct representation of the attractive energy of the unsaturated metal for the carbon–carbon double bond present in alkenes. This approach has the potential to be generally applicable to other gas separations that involve specific coordination-type bonds between adsorbates and adsorbents.
Nutritional composition and antioxidant activity in hazelnut shells from US‐grown cultivars (2012)

Summary The hard shell of a hazelnut is a major waste of the hazelnut industry. The chemical composition, phenolic compounds (total phenolics, tannins and condensed tannins), antioxidant activity (DPPH and ABTS free‐radical scavenging assays), and the relationships between phenolic compounds and antioxidant activities of the hazelnut shells from twelve US grown cultivars were investigated to for potential commercial development. Crude fibre accounted for over 85% of total carbohydrate. The shells contained high concentrations of phenolic compounds. Concentrations of phenolic constituents and ABTS •+ ‐scavenging capacities were significantly higher (P > 0.05) in the Oregon cultivars than their Nebraska counterparts. There were significant positive correlations between ABTS •+ scavenging capacities and the phenolic compounds, whereas DPPH • ‐scavenging capacity demonstrated a weak negative correlation with ABTS •+ scavenging capacity and the phenolics. The results suggest that hazelnut hard shell may serve as a potential source of natural antioxidants for food applications.
Portable Movement Analysis System (1993)

The advent of the portable battery-powered computers and improved video processing technology made possible the Portable Movement Analysis System for field or non-laboratory settings. This system allows visual feedback from multiple cameras with the capabilities for rapid quantitative analyses and provides the same major features currently available with the larger desktop, fixed systems. The system consists of the following components: 80486/33 MHz notebook computer with VGA display, four channel image processing board, programmable data acquisition board, external video monitor, remote controlled 60 Hz video camcorders, portable video cassette recorder, and portable printer. The equipment power requirements are supplied by rechargeable supplies. The online video display allows the action to be monitored by both the performer and the operator at the time of the activity as well as recording the motion for subsequent analyses. Data acquisition can be gathered from analog inputs. The system was tested for interactive analysis of outdoor golf swings. Additionally, in order to obtain a signal at clubhead contact with the ball, a triggered tee was used. The cameras were placed on the front and right sides of the golfer. An external VGA monitor was placed in front of the golfer. The monitor was divided into four divisions. In the upper two screens, the cameras views were displayed. In the bottom screens, the foot pressure correspondingly to the left and right signals were superimposed with the impact signal. The pressure sensitive shoe soles were used to obtqin parameters of body weight transformation during the swing. The instruction period consisted of the identification of screen information indicating, on the digitized stick figure, the points of interest following the 3-D transformation, the determination of angular and linear kinematic parameters, and display of comparative infor mation from the file. For selected attempts, a system analysis of the golf swing was performed. The system analysis consisted of automatic calculations of the following parameters: shoulder/hip angular values at preselected portions of the swing, including the mid point of the back swing, at the top, the mid point of the swing, and at impact; the horizontal and vertical components of the displacement of the center of gravity; the velocities of the clubhead; and the angular velocities at the wrist, elbow, and knee joints. The system was developed as a portable object-oriented and interactive tool for the integration of data acquisition and the processing control of external devices using portable battery-powered components. The system performed as required.
Describing the Tradeoffs Between Persistence and Productivity in Alfalfa (1991)

Substantial plant loss is a commonly accepted phenomenon in commercial alfalfa production. Frequently less than 2% of the seeds originally sown are present in productive mature stands. Optimum yields may not be achieved if the small proportion of plants that survive do not represent the most productive individuals in the original population. We began a study in 1989 to describe the relationships between survival (persistence) and productivity in alfalfa. Sixty 5 yr-old plants were dug from a field of CUF -101 in Pinal Co. (= "Persistent population "). Field performance of progenies of these plants were compared with those of 60 greenhouse -grown CUF-101 plants (= "Random population ") in a 2-yr study in Tucson. In the second year of production spring and fall forage yield and average rate of stem elongation were significantly lower in the Persistent population than in the Random population. These data suggest that plants that are able to persist for the average life of a stand may represent a subset of the original sown population which exhibit more conservative growth patterns. This indicates that simultaneous selection for traits associated with productivity and persistence may be necessary in alfalfa breeding.
Electric transport in liquid silicates (1952)

The first page of this article is displayed as the abstract.
Evaluation of Proteferm® as a Nitrogen Supplement for Finishing Steers (2003)

Proteferm is a liquid by-product from the production of monosodium glutamate by fermentation that is 40% solids and contains 95% crude protein on a dry basis. Two trials were conducted with yearling steers to study the effects of different levels of Proteferm when added to 90% concentrate diets to replace corn and urea. Feeding Proteferm resulted in a decrease in urine pH, suggesting a metabolic acidosis that was probably caused by a negative cation–anion balance. Correcting the cation–anion imbalance resulted in an increase in feed intake and the performance of steers fed Proteferm as 1.5% of diet dry matter to be similar to the performance of control steers. Addition of sodium bicarbonate to the control diet or to the diet containing 1.5% Proteferm to produce a positive cation–anion balance did not improve performance. The results of these trials indicate that 1.5% Proteferm is the maximum that should be added to high concentrate diets fed to beef cattle without affecting performance or carcass value.
Cell Density Modulates the Metastatic Aggressiveness of a Mouse Colon Cancer Cell Line, Colon 26 (2004)

In some cell types, the metastatic activity could be altered and reversed by changing the environment, such as the cell density, during a relatively short period. As a result, the epigenetic changes of cancer cells are thus suggested to play a certain role in the malignant potentiality.
Speaker Recognition Using Neural Tree Networks (1993)

A new classifier is presented for text-independent speaker recognition. The new classifier is called the modified neural tree network (MNTN). The NTN is a hierarchical classifier that combines the properties of decision trees and feed-forward neural networks. The MNTN differs from the standard NTN in that a new learning rule based on discriminant learning is used, which minimizes the classification error as opposed to a norm of the approximation error. The MNTN also uses leaf probability measures in addition to the class labels. The MNTN is evaluated for several speaker identification experiments and is compared to multilayer perceptrons (MLPs), decision trees, and vector quantization (VQ) classifiers. The VQ classifier and MNTN demonstrate comparable performance and perform significantly better than the other classifiers for this task. Additionally, the MNTN provides a logarithmic saving in retrieval time over that of the VQ classifier. The MNTN and VQ classifiers are also compared for several speaker verification experiments where the MNTN is found to outperform the VQ classifier.
Multi-institutional Pivotal Trial of the Zenith TX2 Thoracic Aortic Stent-Graft for Treatment of Descending Thoracic Aortic Aneurysms: Clinical Study Design (2005)

Despite significant improvements in surgical techniques and perioperative management, the repair of descending thoracic aortic aneurysms remains a challenge with the potential for substantial morbidity and mortality. Over the past several years, buoyed by the technical success of endovascular repair of infrarenal abdominal aortic aneurysms, several case series reports of endovascular stent-graft placement for descending thoracic aortic aneurysms have demonstrated the potential safety and efficacy of this treatment modality. Several single-institution studies have documented promising results with these devices, but without controlled clinical trials, the data are insufficient to determine if thoracic aortic endografts provide equivalent or improved outcomes compared with standard open repair. We describe a study design of an ongoing prospective, nonrandomized, multi-institutional, investigational device exemption phase II pivotal clinical trial investigating the safety and effectiveness of the Zenith TX2 thoracic aortic endovascular graft in the elective treatment of patients with descending thoracic aortic aneurysms.
Fibre optic Bragg grating sensor measurements in composite materials (1993)

Despite the many advantages of composite materials, limited data on their inservice performance continues to restrict their application in aircraft structures. Networks of strain sensing elements offer the potential to perform continuous structure health monitoring, as well as gathering information on structure operating conditions. This paper describes some preliminary findings of an ongoing research programme, which aims to implement embedded optical fibre sensing systems. It is envisaged that these systems will be used for health monitoring of composite aircraft components.
A General-Purpose Optimization Technique For Designing Two-Channel Fir Filter Banks (2000)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Social Composer: A Social- Aware Mashup Creation Environment (2010)

International audience
Testicular microlithiasis: a case report and review of the literature (2003)

Testicular microlithiasis (TM) is a rare condition in which men have innumerable testicular calcifications. It is increasingly being reported on ultrasound. The published literature has reported an association between confirmed testicular malignancy and testicular microlithiasis. The relationship between TM and the risk of developing malignancy is unclear. The present paper reports a patient with a previously normal scrotal ultrasound except for bilateral sonographically detected TM who developed a testicular tumour. It also discusses the appropriate management of TM after reviewing the published literature.
Laser technologies in micro-optics. Part 1. Fabrication of diffractive optical elements and photomasks with amplitude transmission (2017)

This paper is a review of studies carried out by the staff of the National Research University of Information Technologies, Mechanics and Optics (ITMO University, Saint-Petersburg) and the Institute of Automation and Electrometry of the Siberian Branch of the Russian Academy of Sciences (IAE SB RAS, Novosibirsk) in the field of development of laser engineering processes for the formation of the structure of diffractive optical elements (DOEs) and photomasks with amplitude binary and grayscale transmission. This paper also describes the results of the study of laser thermochemical technology for fabricating chrome DOEs and technologies for the fabrication of grayscale DOEs and photomasks based on the use of amorphous silicon and LDW glass.
Amino Acids in the Saliva of Patients With Migraine (1999)

There are a number of hypotheses concerning the pathogenesis of migraine, but they are frequently conflicting. In addition to the vascular hypothesis, clinical data are available that excitatory amino acids may play an important role in the development of the disease. In this study, free amino acid concentrations were measured by RP-HPLC in the saliva of 23 migraineurs without aura, 14 migraineurs with aura, and 20 healthy subjects. Significantly higher concentrations of glutamic acid, serine, glycine, arginine, and tyrosine were found in the saliva samples of both groups of migraineurs relative to the control group. It is suggested that amino acids causing hyperexcitability in the central nervous system may be linked to the pathogenesis of migraine.
Cellulases adsorb reversibly on biomass lignin (2018)

Adsorption of cellulases onto lignin is considered a major factor in retarding enzymatic cellulose degradation of lignocellulosic biomass. However, the adsorption mechanisms and kinetics are not well understood for individual types of cellulases. This study examines the binding affinity, kinetics of adsorption, and competition of four monocomponent cellulases of Trichoderma reesei during adsorption onto lignin. TrCel7A, TrCel6A, TrCel7B, and TrCel5A were radiolabeled for adsorption experiments on lignin-rich residues (LRRs) isolated from hydrothermally pretreated spruce (L-HPS) and wheat straw (L-HPWS), respectively. On the basis of adsorption isotherms fitted to the Langmuir model, the ranking of binding affinities was TrCel5A > TrCel6A > TrCel7B > TrCel7A on both types of LRRs. The enzymes had a higher affinity to the L-HPS than to the L-HPWS. Adsorption experiments with dilution after 1 and 24 hr and kinetic modeling were performed to quantify any irreversible binding over time. Models with reversible binding parameters fitted well and can explain the results obtained. The adsorption constants obtained from the reversible models agreed with the fitted Langmuir isotherms and suggested that reversible adsorption-desorption existed at equilibrium. Competitive binding experiments showed that individual types of cellulases competed for binding sites on the lignin and the adsorption data fitted the Langmuir adsorption model. Overall, the data strongly indicate that the adsorption of cellulases onto lignin is reversible and the findings have implications for the development of more efficient cellulose degrading enzymes.
Addressing the Scalability of Ethernet with MOOSE (2010)

Abstract—Ethernet does not scale well to large networks. The flat MAC address space, whilst having obvious benefits for the user and administrator, is the primary cause of this poor scalability; other recent efforts to improve upon Ethernet’s scalability have addressed symptoms, rather than this underlying cause. In this paper we present MOOSE, Multi-level Origin-Organised Scalable Ethernet, an Ethernet switch architecture that performs in-place rewriting of MAC addresses in order to impose a hierarchy upon the address space without reconfiguration or modification of connected devices. This removes the need for switches to maintain large forwarding databases, is of direct use in implementing improved routing, and allows for a variety of other scalability and security innovations. I.
Exploring a modular adaptive metastructure concept inspired by muscle’s cross-bridge (2015)

The multifunctionality and versatility of skeletal muscle is a worthy inspiration towards the development of engineered adaptive structures and material systems. Recent mechanical modeling of muscle suggests that some of muscle’s intriguing macroscale, passive adaptivity results from the assembly of nanoscale, cross-bridge constituents that maintain multiple metastable configurations. Inspired by the new observations, this research explores a concept of creating modular, engineered structures from the assembly of mechanical, metastable modules, defined as modules that exhibit coexistent metastable states. The proposed integrated systems are termed metastructures: modular, engineered structures exhibiting unprecedented characteristics resulting from a synergy of the constituents. Analytical and experimental results demonstrate that when modular metastructures are prescribed a global shape/topology, the systems may yield significant and valuable properties adaptivity including variation in reaction force magnitude and direction, numerous globally stable topologies, and orders of magnitude change in stiffness. The influences of important parameters on tailoring the displacement range of coexistent metastable states are investigated to provide insight of how the assembly strategy governs the intriguing versatility and functionality which may be harnessed.
ChemInform Abstract: Synthesis of Substituted Benzonorbornadienes from Cyclobutenediones. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On maximum field components in the focal point of a lens (2009)

We determine field distributions in the pupil of a high NA lens, that give, for a given power incident on the lens, the maximum electric field amplitude in focus in a specific direction. We consider in particular the cases of maximum longitudinal and maximum transverse components. The distribution of the maximum longitudinal component in the focal plane is narrower than that of the focused Airy spot and hence can give higher resolution in imaging.
Detection of a global aquatic invasive amphibian, Xenopus laevis, using environmental DNA (2016)

Detection is crucial in the study and control of invasive species but it may be limited by methodological issues. In amphibians, classical survey techniques exhibit variable detection probability depending on species and are often constrained by climatic conditions often requiring several site visits. Furthermore, detection may be reduced at low density because probability capture (passive traps), or activity (acoustic surveys) drop. Such limits may impair the study of invasive species because low density is typical of the onset of colonisation on a site. In the last few years, environmental DNA (eDNA) methods have proved their ability to detect the presence of aquatic species. We developed here an eDNA method to detect Xenopus laevis in ponds. This austral African species is now present worldwide because of its use in biology and as a pet. Populations have settled and expanded on several continents so that it is now considered as one of the major invasive amphibians in the World. We detected the presence of X. laevis at density as low as 1 ind/100 m 2 and found a positive relationship between density in ponds and rate of DNA amplification. Results show that eDNA can be successfully applied to survey invasive populations of X. laevis even at low density in order to confirm suspected cases of introduction, delimit the expansion of a colonized range, or monitor the efficiency of a control program.