gebhart/patrepeval huggingface dataset:
Appropriateness of antibiotic management of uncomplicated skin and soft tissue infections in hospitalized adult patients (2016)

In the majority of patients, treatment duration was excessive. Inappropriate broad spectrum antibiotic selection was utilized with regularity for SSTIs without complicating factors. The management of uncomplicated SSTIs represents a significant opportunity for antimicrobial stewardship.
Organometallic Polysilylenes. First Organometallic Route to Fe−SiC Composites (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTOrganometallic Polysilylenes. First Organometallic Route to Fe−SiC CompositesCezar UngurenasuView Author Information "P. Poni" Institute of Macromolecular Chemistry of the Romanian Academy, Aleea Ghica Voda 41-A, 6000 Iasi, Romania Cite this: Macromolecules 1996, 29, 22, 7297–7298Publication Date (Web):October 21, 1996Publication History Received12 October 1995Revised25 July 1996Published online21 October 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ma9515184https://doi.org/10.1021/ma9515184rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views79Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Composites,Copolymers,Iron,Polymers,Pyrolysis Get e-Alerts
Emerging Role for Autophagy in the Removal of Aggresomes in Schwann Cells (2003)

The presence of protein aggregates in the nervous system is associated with various pathological conditions, yet their contribution to disease mechanisms is poorly understood. One type of aggregate, the aggresome, accumulates misfolded proteins destined for degradation by the ubiquitin-proteasome pathway. Peripheral myelin protein 22 (PMP22) is a short-lived Schwann cell (SC) protein that forms aggresomes when the proteasome is inhibited or the protein is overexpressed. Duplication, deletion, or point mutations in PMP22 are associated with a host of demyelinating peripheral neuropathies, suggesting that, for normal SC cell function, the levels of PMP22 must be tightly regulated. Therefore, we speculate that mutant, misfolded PMP22 might overload the proteasome and promote aggresome formation. To test this, sciatic nerves of Trembler J (TrJ) neuropathy mice carrying a leucine-to-proline mutation in PMP22 were studied. In TrJ neuropathy nerves, PMP22 has an extended half-life and forms aggresome-like structures that are surrounded by molecular chaperones and lysosomes. On the basis of these characteristics, we hypothesized that PMP22 aggresomes are transitory, linking the proteasomal and lysosomal protein degradation pathways. Here we show that Schwann cells have the ability to eliminate aggresomes by a mechanism that is enhanced when autophagy is activated and is primarily prevented when autophagy is inhibited. This mechanism of aggresome clearance is not unique to peripheral glia, because L fibroblasts were also capable of removing aggresomes. Our results provide evidence for the involvement of the proteasome pathway in TrJ neuropathy and for the role of autophagy in the clearance of aggresomes.
CFD Time-Integration Strategies for Large Chemical Systems (2006)

Abstract : To date, we have developed and implemented (into our GASP CFD Slow solver) a loosely-coupled strategy for the fluid-dynamic chemical systems. The approach uses the lower-upper, symmetric, Gauss-Siedel (LU-SGS) implicit scheme to advance the fluid-dynamic system. In most cases, the chemical reactions have much smaller time scales than those associated with the flow, result stiffness due to the source terms. Solution of the chemical system uses a time-operator splitting approach that allows isolation of the stiff source term from the transport terms. As a result, the solution process can be divided into two fractional steps - a transport fractional step and chemical production (or reaction) fractional step. The chemical transport fractional step is currently solved using simple, low-cost Euler explicit scheme. The chemical production fractional step involves solving a system of ordinary differential equations representing the chemical source term and is carried out using a variable coefficient ordinary differential equation solver (DVODE).
Predicting Customer Call Intent by Analyzing Phone Call Transcripts based on CNN for Multi-Class Classification (2019)

Auto dealerships receive thousands of calls daily from customers who are interested in sales, service, vendors and jobseekers. With so many calls, it is very important for auto dealers to understand the intent of these calls to provide positive customer experiences that ensure customer satisfaction, deep customer engagement to boost sales and revenue, and optimum allocation of agents or customer service representatives across the business. In this paper, we define the problem of customer phone call intent as a multi-class classification problem stemming from the large database of recorded phone call transcripts. To solve this problem, we develop a convolutional neural network (CNN)-based supervised learning model to classify the customer calls into four intent categories: sales, service, vendor and jobseeker. Experimental results show that with the thrust of our scalable data labeling method to provide sufficient training data, the CNN-based predictive model performs very well on long text classification according to the quantitative metrics of F1-Score, precision, recall, and accuracy.
A novel frequency synchronization method for wireless OFDM systems (2005)

In this paper, we propose a new frequency synchronization method for wireless orthogonal frequency division multiplexing (OFDM) systems. The method exploits the pilots' energy efficiently by collecting the energy leaked into the neighbor subcarriers, and provides the coarse and fine estimation of the frequency offset at the same time. Furthermore, an adaptive accumulator is used to attain a good tradeoff between the performance and the synchronization time. Computer simulation results demonstrate that the proposed method performs well at various Doppler frequency shifts with a fairly short synchronization time.
A high-performance monolithic instrumentation amplifier (1971)

Differential input with high CMR and input impedance has been achieved with single resistor gain selection on a monolithic chip by combination of a differential input/ single-ended output and differential input/differential output amplifier in a current feedback loop.
Dornase alpha and exhaled NO in cystic fibrosis (2004)

Nitric oxide (NO) that is produced within the airways can be measured in the exhaled air. Concentrations of exhaled NO (FENO) are decreased in cystic fibrosis (CF) and, in cross sectional studies, have been shown to be even lower in patients with more advanced pulmonary disease. This may result from retention and metabolisation of NO within viscous airway secretions. Treatment with recombinant human DNase I (dornase alpha) modifies the rheological properties of airway secretions and thereby improves pulmonary function even in young and apparently healthy patients with CF. We studied FENO and pulmonary function in children with CF with little clinical evidence of lung morbidity in a two-year randomized double-blind placebo-controlled study with nebulized dornase alpha. Mean age at enrollment was 8 years (range 6 to 11 years), mean forced vital capacity (FVC) was 112% (range 86 to 133%), and mean forced expiratory volume in one second (FEV1)was 109% (range 88 to 128%) of predicted values. In five of six (83%) of the dornase alpha treated patients, FENO changed in parallel to changes in pulmonary function tests while no such correlation was observed in any of the eight patients receiving placebo. This difference between treatment groups was statistically significant for both FVC (P = 0.026, Wilcoxon-test) and FEV1 (P = 0.042). These data suggest that FENO may serve as a surrogate measure for evaluating the effectiveness of interventions that affect airway clearance in CF.
Identificación de antígenos de quistes y trofozoítos de aislamientos colombianos de Giardia duodenalis reconocidos por IgA. (2003)

Little is known about the role of IgA in the immune response against Giardia duodenalis infection. The current study identified the antigens of Colombian G. duodenalis isolates which stimulate the production of IgA anti-G. dudoenalis. Cyst and trophozoite stage proteins were separated by SDS-PAGE and their antigenicity was determined by Western blot. Without 2-mercapto ethanol (2-ME), the protein profile of the cyst stage showed 24 proteins within a molecular weight range of 23-270 kDa; with 2-ME, 35 polypeptides ranging from 22 to 241 kDa were distinguished. The trophozoite stage protein profile without 2-ME was formed by 16 proteins within the range of 24-270 kDa; with 2-ME, 45 proteins were present between 18 and 241 kDa. The identification of 20 and 29 antigens from the cyst and trophozoite stage, respectively, suggested that G. duodenalis stimulates a specific humoral immune response in the human host. The antigens of 31, 57, 110, 133, and 170 kDa recognized by anti-G duodenalis IgA in both cysts and trophozoites corresponded with G. duodenalis isolates from other geographic regions, whereas those of 35, 38, 43, 45, 49, 52, 60, 62, 65, 72, 82, 99, 145, 155, and 185 kDa seemed specific to Colombian isolates. This indicated that antigens of 57, 65, 145, and 170 kDa, recognized by anti-G. duodenalis IgA antibodies in cysts (with frequencies between 82% and 96%) and trophozoites (with frequencies between 86% and 97%) can be considered identification markers for G. duodenalis infections.
A SystemC TLM2 model of communication in wormhole switched Networks-On-Chip (2009)

Networks-On-Chip (NoC) are a promising approach to connect the increasing number of components being integrated into Systems-on-Chip. In order to meet the growing demands for the simulation of such systems, abstraction techniques like Transaction Level Modelling (TLM) are used to describe the communication. In this work, we investigate the application of SystemC TLM2 for modelling network-based interconnects at early design stages, providing fast simulation by describing end-to-end communication with a single transaction at the expense of reduced accuracy.
A general class of current amplifier-based biquadratic filter circuits (1992)

A general class of current amplifier-based biquadratic filter circuits capable of realizing arbitrary filter functions including the low-pass, high-pass, and bandpass transfer functions is presented. These realizations are derived from a class of well-known low sensitivity single amplifier biquadratic (SAB) filter circuits using the principle of adjoint networks. The salient features of the proposed circuits are that they are synthesized using the same procedure as their op-amp-based SAB circuit counterparts, and they possess the same sensitivities to component variations as the original SAB circuits. However, it is demonstrated experimentally that unlike op-amp-based SAB realizations whose effective operating bandwidth is much less than the unity-gain bandwidth of the op-amp, these current-based filter circuits are effective over the entire bandwidth of the current amplifier.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CORPORATE ENTREPRENEURSHIP AND VALUE CREATION FOR STOCKHOLDERS (2011)

Tyrosine kinase inhibition with imatinib appears to be a novel therapeutic option to retard the development of atherosclerosis, specifically in the context of diabetes.
C/EBPbeta is a Negative Regulator of Skeletal Muscle Differentiation (2011)

C/EBPβ is a bZIP transcription factor known to be involved in various physiological processes, including adipogenesis, osteogenesis and liver development. Previous studies in this laboratory revealed an inhibition of myogenesis and reduced myogenic protein expression in 5-azacytidine treated mesenchymal stem cells retrovirally transduced to overexpress C/EBPβ. The goal of this thesis was to evaluate the role of C/EBPβ in myogenic differentiation by overexpression in C2C12 myoblasts and primary myoblasts. We demonstrate reduced MyoD protein expression and subsequent downregulation of myogenic proteins during differentiation following C/EBPβ overexpression. We localized C/EBPβ to the quiescent Pax7+ satellite cells associated with the muscle fiber. Upon satellite cell activation, we observed the downregulation of C/EBPβ protein expression prior to MyoD protein expression. Furthermore, the re-expression of C/EBPβ correlated with the loss of MyoD expression later in differentiation. Histological analysis of C/EBPβ-/- mice revealed smaller fibers and a reduced Pax7+ satellite cell population as compared to control animals. In this thesis, we propose that C/EBPβ is a negative regulator of skeletal muscle differentiation by inhibiting the expression of MyoD, thus impairing proper progression through the myogenic program. In addition, we propose a role for C/EBPβ in the maintenance of undifferentiatied satellite cells.
A Combination of Enhanced WordNet and BERT for Semantic Textual Similarity (2021)

The task of measuring sentence similarity deals with computing the likeness between a pair of sentences by adopting Natural Language Processing techniques (Euclidean distance, Jaccard distance, Manhattan distance, etc.) as well as embedding techniques (word2vec, GloVe, Flair, etc.). For the purpose of determining sentence similarity, this paper proposes a novel, ensemble learning approach which uses the WordNet corpus and the Bidirectional Encoder Representations from Transformers (BERT) in order to consider the context of words in sentences while computing the similarity scores. The accuracy of the proposed model is computed by calculating the Pearson and Spearman scores for the sentence pairs from the Sentences Involving Compositional Knowledge (SICK) dataset. On analyzing the results, the proposed approach is observed to outperform existing state-of-the-art semantic textual similarity models since it returns the highest correlation scores. Further, this paper also introduces a possible machine learning approach for the same and evaluates its scope and drawbacks.
Communication Policy at the Chalk Face in Scotland and Jamaica: Complexity as a New Paradigm for Understanding Language Policy Interpretation and Implementation (2003)

This article examines teachers classroom interaction with upper primary pupils and the implications for the implementation of stated language policy aims in two contexts where there are tensions between local community languages and the recognised language of the global marketplace, namely Scotland and Jamaica. Following Wertsch and Smolka (1993) the article argues that it is often in very subtle ways that teachers either encourage or restrict the amount of dialogue and exchange there can be in their classroom. Informal exchanges within the classroom can be vital for children to work through their own strategies for navigating their multi-lingual context. The article also illustrates that the metaphor of fractals derived from complexity sciences (Wolfram Research, 2003) can form a more sensitive and appropriate framework for discourse analysis.
The national science foundation and support for social science computing (1974)

Nearly two years ago, I spent several months working as a Professional Assistant in the Office of Computing Activities at the National Science Foundation in Washington, D.C. Although my assignment was to develop a concept for a program on "Computer Impact on Society", I had opportunity to become familiar with some of the projects supported in the area of computer applications for the social sciences. Actually I was already familiar with most of the projects that had been supported. However, the work assignment enabled me to have an expanded and slightly different perspective on these projects.
Steelmaking Practices and Their Influence on Properties (1998)

Abstract This article presents a detailed account on the process flow, composition, alternative sources, and the advancement of ironmaking, steelmaking and secondary steelmaking practices. Some steels, such as bearing steels, heat-resistant steels, ultrahigh strength missile and aircraft steels, and rotor steels have higher quality requirements and tighter composition control than plain carbon or ordinary low-alloy steels. The production of special-quality steels requires vacuum-based induction or electric remelting and refining capabilities. The article explores the types and characteristics of various steel manufacturing processes, such as ingot casting, continuous casting, and hot rolling. It provides an outline of specialized processing routes of producing ultralow plain carbon steels, interstitial-free steels, high strength low-alloy steels, ultrahigh strength steels, stainless steels, and cold-rolled products, and briefly explains the analytical techniques for liquid steels.
Object oriented simulation with Smalltalk-80: a case study (1991)

The authors relate their experience with object-oriented simulation. They begin with a few historical developments that led to object-oriented programming. The objectives of an object-oriented simulation model developed as a case study are presented. A virtual cellular manufacturing system which has served as the referent system for the experimentation is introduced. The object-oriented modeling methodology which has been followed during the incremental phases of development and the strategic and tactical plan for sustaining the experimental investigation are presented. Finally, the results of the experimental investigation that focus uniquely on the object-oriented experience are presented. It is concluded that Smalltalk provides an excellent set of features, capable of supporting object-oriented discrete-event simulation. >
On the design of optimum radar waveforms for clutter rejection (1967)

The problem to be considered in this paper is that of designing radar signals and receivers that are optimum for detecting a point target masked by a background of clutter returns and thermal noise. The problem of choosing an optimum signal when no constraints are placed on the type of signals allowed is discussed briefly, but the remainder of the paper is restricted to signals and receiver impulse responses that are uniformly spaced, phase and amplitude-tapered pulse trains. Expressions for the signal-to-interference ratio obtained when a signal is used with its matched filter (pm/) and with the optimum filter or clutter filter <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(\rho_{cf})</tex> are then derived together with an explicit expression for the clutter filter. An iterative technique for maximizing <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\rho_{cf}</tex> is devised. This scheme has the useful property that it generates a sequence of signals whose <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\rho_{cf}</tex> 's form a monotone, nondecreasing sequence. This is followed by an application of the calculus of variations to derive the Euler equations for the stationary points of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\rho_{cf}</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\rho_{mf}</tex> . The form of the Euler equations suggests iterative techniques for their solution; in fact, the technique suggested for the solution of the Euler equation associated with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\rho_{cf}</tex> is essentially the iterative technique that was described above.
Mapping wafer flatness changes in chemical mechanical planarization (2002)

This paper discusses the feasibility of using non-contact capacitive gauging technology for wafer flatness characterization in Chemical Mechanical Planarization (CMP). A simple but efficient method is introduced which provides guidance for CMP wafer flatness qualification per advanced lithography requirements. The statistical analysis quantitatively explains why CMP is an enabling technology for surface planarization in sub-half micron or less technologies. A gain of approximate 7% in terms of site flatness improvement at 0.18 /spl mu/m technology is observed which represents a significant yield improvement from a lithographic perspective.
Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial (2014)

Netherlands Trial Registry, NTR1576: MAPLE (Melatonin Against PLacebo in Elderly patients) study; www.trialregister.nl/trialreg/admin/rctview.asp?TC=1576.
KinMutBase, a database of human disease-causing protein kinase mutations (2000)

KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases. There are 251 entries altogether, representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations and changes to restriction enzyme patterns.
[Radiographic and histological study of a case of apexification in a human molar]. (1990)

A case of apexification in a lower right second molar is described. Radiographs demonstrate apical closure with a different morphological pattern from that of the lower left second molar. Following extraction, after 15 months, serial histologic sections show calcified tissue obturating the apical foramen, well adapted to the initial dentin and cementum walls. Inside some small areas containing connective tissue with capillaries can be observed. The histologic and radiographic observations indicate that apical closure occurs as a result of differentiation of periodontal apical cells.