gebhart/patrepeval huggingface dataset:
Preparation and biological evaluation of technetium-99m-L,L-propylenedicysteine (1999)

In this study we have investigated the influence of replacement of the ethylene moiety in 99mTc-L,L-ethylenedicysteine (99mTc-L,L-EC) by a propylene moiety on the physical and biological properties. S,S′-dibenzyl-N,N′-1,3-propylenediylbis-L-cysteine was synthesised by reaction of S-benzyl-L-cysteine with 1,3-dichloropropane. The thiol groups were deprotected with sodium in liquid ammonia. The resulting L,L-propylenedicysteine (L,L-PC) was directly labelled with 99mTc at pH 12. Whereas labelling of L,L-ED results in a single radiochemical species, labelling of L,L-PC yields two 99mTc-complexes in a 3/1 ratio, probably two isomers with the central propylene carbon atom syn or anti to the oxotechnetium core. These isomers are stable and do not interconvert at neutral pH. In mice, both isomers of 99mTc-L,L-PC showed a slower urinary excretion and a higher hepatobiliary uptake than 99mTc-L,L-EC. Furthermore, 99Tc-L,L-PC showed some renal retention. In a baboon, both conformers of 99mTc-L,L-PC were excreted rapidly in the urine without visualisation of liver or intestines, but their plasma clearance was only 33.6% of hippuran clearance for isomer A and 25.6% for isomer B, as compared to 75% in the case of 99mTc-L,L-EC. The results indicate that, besides the oxotechnetium-glycine sequence, also the length and orientation of the alkylene bridge between the two amines are important for the interaction of this type of compounds with the renal tubular transport proteins. Copyright © 1999 John Wiley & Sons, Ltd.
New Concepts in Cancer (1990)

This book defines and reviews the clinical status of metastatic disease and the present status of response to radiation and chemotherapy, identifies factors associated with and/or responsible for tumo
Protease-Activated Receptor (PAR), a Novel Family of G Protein-Coupled Seven Trans-membrane Domain Receptors: Activation Mechanisms and Physiological Roles (2000)

The protease-activated receptor (PAR) belongs to the large superfamily of G-protein-coupled seven trans-membrane domain receptors. The activation of PARs is achieved by proteolytic unmasking of the cryptic N-terminal receptor-activating sequence that binds to the body of the same receptor molecule. PARs-1, -3 and -4 are activated by thrombin, while PAR-2 is activated by trypsin or mast cell tryptase, but not by thrombin. PARs are widely distributed to a variety of tissues and participate in a number of physiological or pathophysiological phenomena such as platelet aggregation, inflammation and cardiovascular, digestive or respiratory functions. Thus, PARs are of physiological importance and also of pharmacological interest as the novel target for drug development.
Parathyroid Hormone as a Trophic Hormone for 1,25-Dihydroxyvitamin D<sub>3</sub>, the Metabolically Active Form of Vitamin D (1972)

Well known to the clinician is the fact that hypoparathyroid patients require large amounts of vitamin D or its close analogue, dihydrotachysterol, for the maintenance of reasonable plasma calcium concentrations. Not so well recognized is the fact that the presence of vitamin D or its metabolites is required for the parathyroid hormone to carry out its well known bone calcium mobilization function in the elevation of serum calcium concentration.1 Finally, hypoparathyroid patients who are resistant to massive amounts of vitamin D have been described.2 From these facts it seems clear that the bone function of both the parathyroid hormone and . . .
Inhibition of tumor growth through suppression of angiogenesis by brain-specific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma (2007)

This study was designed to elucidate the therapeutic effect of transfering the brain-specific angiogenesis inhibitor 1 (BAI1) gene to a mouse renal cell carcinoma cell line (Renca). Female BALB/c mice were inoculated subcutaneously with wild-type Renca (Renca/Wild) cells or Renca cells transfected with the BAI-1 (Renca/BAI-1) or LacZ (Renca/LacZ) gene. Tumor growth was observed every other day from 3 to 35 days after implantation. Moreover, the intratumoral injection of the adenovirus vector containing the gene encoding BAI1 was conducted at two-day intervals from 11 to 31 days after implantation of the Renca/Wild or Renca/BAI1 tumor. Tumor blood flow was measured by colorimetric angiogenesis assay (CAA). The concentration of the vascular endothelial growth factor (VEGF) in the cell culture supernatants was determined by enzyme-linked immunoassay. The size of the Renca/BAI1 tumor was significantly (p<0.01) suppressed compared to the Renca/Wild and Renca/LacZ tumors 21 days after tumor implantation. The injection of the BAI1 viral vector at 2-day intervals significantly inhibited the growth of both the Renca/Wild and Renca/BAI1 tumors. The blood volume measured by CAA and microvessel density was significantly lower in the Renca/BAI1 than in the Renca/Wild and Renca/LacZ tumors (p<0.01 and p<0.05, respectively). A significant (p<0.01) reduction in VEGF concentration in the supernatant was demonstrated in the Renca/BAI1 compared with the Renca/Wild and Renca/LacZ cell cultures. These observations suggest that the transfer of the BAI1 gene to Renca can suppress the tumor growth via the inhibition of angiogenesis. The down-regulation of VEGF production in tumor cells contributes to this anti-tumor effect.
NEW SETS OF TESTING CODES PROVIDING ZERO RANGE SIDELOBES FOR ULTRASONIC PULSE COMPRESSION STRUCTIVE TESTING SYSTEMS (1992)

Abstract In conventional ultrasonic pulse compression nondestructive testing systems, complementary codes have been used for modulation of transmit signals in order to obtain zero range sidelobes. In this paper,new sets of testing codes for modulation of transmit signals are shown. The sets are composed of four or more codes and provide zero range sidelobes. In the code lengths less than fifty, the new sets exist at least in twelve different kinds of lengths, for which the conventional complementary codes do not exist. The new sets of testing codes expand the selection range of code lengths providing zero range sidelobes, and thus. arc useful for reduction of dead time in a system using a transducer for both transmission and reception. Sidelobe cancellation using the new sets is demonstrated by experiments.
Soybean Cultivar Identification Using High Performance Liquid Chromatography of Chromatography of Seed Proteins (1989)

A substantial increase in the number of soybean [ Glycine max (L.) Merr.J cultivars has occurred in recent years. Many of these are derived from a narrow genetic base, which makes traditional cultivar identification increasingly difficult. As a result, new techniques that detect minor biochemical differences need to be evaluated for their ability to differentiate among cultivars. This study examines the applicability of reversed phase high performance liquid chromatography (RP‐HPLC) for soybean cultivar identification. Salt soluble proteins of 14 cultivars were extracted from unimbibed seeds, eluted from a reversed phase C4 column with increasing concentrations of acetonitrile, and monitored at 280 nm. Seeds were obtained for study from three differing growing locations in Ohio. While no qualitative differences of elution profiles were detected within cultivars and locations, comparisons of quantitative RP‐HPLC seed protein profiles permitted separation of genetically diverse genotypes. Retention time ratios for selected peaks were not significantly different among cultivars, but peak area percentage showed that quantitative differences were useful criteria for distinguishing closely related lines. This study documents that RP‐HPLC analysis of soybean seed proteins can distinguish divergent soybean genotypes and suggests that peak area percentage of RP‐HPLC profiles is a superior method of cultivar analysis.
THE HEAT OF COMBUSTION OF THULIUM<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE HEAT OF COMBUSTION OF THULIUM1Elmer J. Huber Jr., Earl L. Head, and Charles E. Holley Jr.Cite this: J. Phys. Chem. 1960, 64, 3, 379–380Publication Date (Print):March 1, 1960Publication History Published online1 May 2002Published inissue 1 March 1960https://pubs.acs.org/doi/10.1021/j100832a510https://doi.org/10.1021/j100832a510research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Synaptic Vesicle Exocytosis (2011)

Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis. Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is affected by a universal machinery that includes SNARE (for "soluble NSF-attachment protein receptor") and SM (for "Sec1/Munc18-like") proteins. During fusion, vesicular and target SNARE proteins assemble into an α-helical trans-SNARE complex that forces the two membranes tightly together, and SM proteins likely wrap around assembling trans-SNARE complexes to catalyze membrane fusion. After fusion, SNARE complexes are dissociated by the ATPase NSF (for "N-ethylmaleimide sensitive factor"). Fusion-competent conformations of SNARE proteins are maintained by chaperone complexes composed of CSPα, Hsc70, and SGT, and by nonenzymatically acting synuclein chaperones; dysfunction of these chaperones results in neurodegeneration. The synaptic membrane-fusion machinery is controlled by synaptotagmin, and additionally regulated by a presynaptic protein matrix (the "active zone") that includes Munc13 and RIM proteins as central components.
Estimating microbial risk in treated wastewater for reuse: a case study in Lund, Sweden (2014)

The potential microbial risk from using treated wastewater is a burning issue to be studied. In Sweden, only a small part of treated wastewater is reused directly, although water reuse could be beneficial. Disinfection is virtually never practised and no protective guidelines for water reuse are found in Sweden. Based on a 1 year monitoring programme of water quality, this paper estimates the microbial risk of Escherichia coli and rotavirus in treated wastewater for different applications of irrigation, landscape, industry, unban non-potable water. A Quantitative Microbial Risk Assessment model is used and the samples were collected from the pond system of Källby wastewater treatment plant in Lund, Sweden. The results are used to evaluate if the treated wastewater after tertiary treatment process combined with pond system can be reused for different applications from a microbial point of view. The risk assessment results show that the studied water is only suitable for agriculture irrigation, while additional treatment or disinfection are needed for other applications since the potential risks are higher than the value that can be accepted. The protective guidelines are discussed based on the process and results of risk assessment and suggestions for establishing a structure of guidelines in Sweden are presented.
Effectiveness analysis of a non-destructive Single Event Burnout test methodology (2013)

It is essential to characterize power MosFETs regarding their tolerance to destructive Single Event Burnouts (SEB). Therefore, several non-destructive test methods have been developed to evaluate the SEB cross-section of power devices. Power MosFETs have been evaluated using a test circuit, designed according to standard non-destructive test methods discussed in the literature. However, destructive events were observed and affected the evaluation of the cross-section. This paper analyzes results obtained using different test circuit configurations based on standard non-destructive test methodologies and evaluates their respective effectiveness. In addition, protection methods are discussed and simulations are performed to better understand the underlying effects.
Periodate Oxidation of Glycopeptides from Ovalbumin<sup>*</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPeriodate Oxidation of Glycopeptides from Ovalbumin*Rex Montgomery, Ya-Chen Wu, and Yuan Chuan LeeCite this: Biochemistry 1965, 4, 3, 578–587Publication Date (Print):March 1, 1965Publication History Published online1 May 2002Published inissue 1 March 1965https://doi.org/10.1021/bi00879a031RIGHTS & PERMISSIONSArticle Views101Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (883 KB) Get e-Alerts Get e-Alerts
How to evaluate the separation efficiency of CZE methods? (2011)

In trying to estimate the separation efficiency of Capillary Electrophoresis (CE) methods, the resolution (RS), the number of theoretical plates (N) and the peak-to-valley ratio (p/v) are often used assessment criteria. This study demonstrates that these criteria are not as suitable to describe the separation efficiency in case of Capillary Zone Electrophoresis (CZE) methods as they are for Liquid Chromatography (LC) methods. The investigations were performed by means of a validated CZE method for the evaluation of tetracyclines and their related substances. Four impurities of tetracycline hydrochloride are described in the European Pharmacopoeia. Three were found in the sample used for our investigations, i.e. epi-tetracycline formed by keto-enol-tautomerism, anhydrotetracyclin and epi-anhydrotetracyline. It could be shown that higher values of these assessment criteria like RS do not necessarily represent better separation. Thus, a discussion on the usefulness of separation selectivity and efficiency as assessment criteria for capillary electrophoresis as well as on the introduction of additional parameters is needed.
Efficient Use Of High-Frequency Data Through Production Data Management System Implementation (2012)

Abstract The McCully Field (New Brunswick, Canada) is highly instrumented and generates a massive quantity of high-frequency data stored in a data historian. Data time range and frequency of interest had to be manually retrieved through spreadsheet macros for analysis, plotting, and gas allocation. As the production history grew, the amount of data generated was overwhelming and unconsolidated, making the task of manual data handling and visualization both difficult and time consuming. The implementation of a production data management system resulted in a fully automated, end-to-end workflow that acquires five-minute data from the Supervisory Control and Data Acquisition (SCADA) system into the operating database; performs accurate allocation of gas, condensate and water volumes; as well as creates and distributes daily production summaries to a custom email list in a matter of minutes. The implementation of an automated approach was driven by five main objectives: automate production data acquisitionoptimize field production through real-time well surveillanceincrease data processing speed (reduce time spent on data handling, preparation, cleansing and reporting)take advantage of existing high-frequency databaseimprove communications regarding well performance between office and field operations After a successful implementation, data acquisition time has been reduced from a manual 30 minutes to an automated 5 minutes each day. Daily production reports, instead of only being accessible through the server, are now automatically emailed to a distribution list within the company. Real-time well surveillance is now possible from the main office and not only through the SCADA system in the field, which provides the engineering group with a better understanding of individual well performance and also allows any production disruptions to be identified early and resolved efficiently. Finally, the consolidated database is now integrated with engineering analysis tools for further use of information, which ultimately increases the effectiveness of the technical team.
Dimensional Tolerancing and Control in Molded Products (2003)

Design and manufacturing of engineered products are subject to uncontrolled variation (noise) and unknown performance behavior and/or requirements (uncertainty). Skilled practitioners currently utilize robust design and Six Sigma techniques for tolerance specification and parametric optimization to control the mean and variance of the performance characteristics. Even after several design iterations, however, the final product and process design may not be optimal and result in unacceptable performance or quality levels. This paper explores the validity of current Six Sigma practices for dimensional tolerancing and process optimization in the manufacturing of an injection molded plastic part. Specifically, the use of process capability indices and aggregate performance measures are discussed relative to the shrinkage behavior of isotactic polypropylene, i-PP. The results indicate that uncertainty and covariance between multiple part dimensions can invalidate standard practices. While current best practices may be better than completely unstructured approaches, the resulting product and process designs provide suboptimal product characteristics, broad performance distributions, and low manufacturing yields.
Ring Transformation of 1,2‐Disubstituted 4(1<i>H</i>)‐Quinazolone Oximes to 3,5‐Disubstituted 1,2,4‐Oxadiazoles (1989)

Abstract In basic media O ‐Benzoyl‐ and O ‐acetyl‐2‐benzylaminobenzamide oxime ( 8b , c ) give 5‐substituted 3‐(2‐benzylaminophenyl)‐1,2,4‐oxadiazoles ( 9a , b ), while on heating in pure water 2‐amino‐1‐benzylbenzimidazole ( 10 ) is formed. Reaction of 2‐( N ‐acylbenzylamino)benzonitrile ( 12 ) with hydroxylamine, or treatment of O ‐acyl‐2‐( N ‐benzoylbenzylamino)benzamide oximes ( 8f , g ) with acid give the novel 1,2‐disubstituted 4(1 H )‐quinazolone oximes 13 , which isomerize on heating with alkali by an ANRORC mechanism to the 1,2,4‐oxadiazoles 9a , b .
Feeding Behavior of Gypsy Moth (Lepidoptera: Lymantriidae) Larvae on Artificial Diet ContainingBacillus thuringiensis (1995)

The effects of Bacillus thuringiensis Berliner in artificial diet on the feeding behavior of lalvae of the gypsy moth, Lymontria dispar (L.), were measured in both short-term (1 d) and long-term (10 d) tests. In short-term tests, reduced rates of feeding, growth, and digestive efficiency were caused by B. thuringiensis at concentrations that did not kill larvae within the duration of the tests. In long-term tests, larvae given a choice between treated and untreated diets avoided diet containing B. thuringiensis for the first 7 d. After 7 d, increased movement by the larvae apparently obscured effects of B. thuringiensis on the distribution of the larvae. Effects of B. thuringiensis on the feeding behavior of gypsy moth larvae may, therefore, be one reason why high rates of mortality of gypsy moth are difficult to obtain with B. thuringiensis under field conditions.
Estimation, par utilisation de semence congelée, des effets de la sélection réalisée entre 1977 et 1998 dans la population Large White sur la composition corporelle et l'état physiologique du porc nouveau-né (2005)

est destine au dpt et la diffusion de documents scientifiques de niveau recherche, publis ou non, manant des tablissements d'enseignement et de recherche franais ou trangers, des laboratoires publics ou privs.
Three-dimensional thoracic aorta principal strain analysis from routine ECG-gated computerized tomography: feasibility in patients undergoing transcatheter aortic valve replacement (2018)

Three-dimensional aortic PPSA analysis is clinically feasible from routine ECG-gated CTA. Appropriate reductions in PSSA were identified with increasing AS hemodynamic severity. Expanded study of 3D aortic PSSA for patients with various forms of aortic disease is warranted.
All-digital receiver structures for MC-UWB systems (2003)

We introduce all-digital receiver structures for ultra wideband orthogonal frequency division multiplexing (UWB-OFDM) systems. These all-digital receiver structures are digital equivalents or extensions of equivalent analog structures that have previously been proposed. The structures use one bit K-tone sigma-delta analog-to-digital converters. They deal with multipath, observation and quantization noise simultaneously. The digital implementation of different receivers, such as maximum likelihood multi-carrier (ML-MC) receiver, single-carrier RAKE receiver and sub-carrier pilot assisted receiver, are studied.
Fully suspended nanophotonic waveguide resonators with high quality factor and tailorable operational bandwidth (2017)

We demonstrate fully suspended nanophotonic waveguide ring and racetrack resonators with high loaded quality factors of 39,900 and 40,600 respectively in the mid-infrared regime. A two-fold enhancement in the operational bandwidth is achieved.
Modeling lidar returns from forest canopies (2000)

Remote sensing techniques that utilize light detection and ranging (lidar) provide unique data on canopy geometry and subcanopy topography. This type of information will lead to improved understanding of important structures and processes of Earth's vegetation cover. To understand the relation between canopy structure and the lidar return waveform, a three-dimensional (3D) model was developed and implemented. Detailed field measurements and forest growth model simulations of forest stands were used to parameterize this vegetation lidar waveform model. In the model, the crown shape of trees determines the vertical distribution of plant material and the corresponding lidar waveforms. Preliminary comparisons of averaged waveforms from an airborne lidar and model simulations shows that the shape of the measured waveform was more similar to simulations using an ellipsoid or hemi-ellipsoid shape. The observed slower decay of the airborne lidar waveforms than the simulated waveforms may indicate the existence of the understories and may also suggest that higher order scattering from the upper canopy may contribute to the lidar signals. The lidar waveforms from stands simulated from a forest growth model show the dependence of the waveform on stand structure.