gebhart/patrepeval huggingface dataset:
Postpartum depression, marital dysfunction, and infant outcome: a longitudinal study. (2002)

This longitudinal study explores the relationship of postpartum depression (PPD) and marital dysfunction on infant outcomes from birth to 2 1/2 years of age among middle-class, postpartum women. Participants were recruited during the prenatal period. Twelve mothers completed the study throughout a 2 1/2-year period. Questionnaires, semistructured interviews, and observations were used to collect data. Content analysis of the interviews (Morse & Field, 1995) was conducted and thematic patterns were identified. Clinical PPD and marital dysfunction (defined as little or no support or closeness, or verbal, emotional or physical abuse) characterized nearly one in three mothers. Four themes describing the women's postpartum progression were identified: stress, isolation, resentment, and eventual adjustment by creating a new normal. No major developmental delays or behavioral problems were found among the infants. Eight of the 12 mothers who were initially identified as breastfeeding nursed their infants for 6-18 months. Regardless of financial and educational advantages, mothers in the study experienced depression and marital dysfunction. These findings support other studies that confirm the lack of association of PPD with social class or marital status. Childbirth educators and other health care professionals are encouraged to continue providing expectant families with anticipatory education and community resources in order to increase awareness of mental health and marital risks during the postpartum transition.
Integrated Approach for Manual Evaluation of Peptides Identified by Searching Protein Sequence Databases with Tandem Mass Spectra (2005)

Quantitative proteomics relies on accurate protein identification, which often is carried out by automated searching of a sequence database with tandem mass spectra of peptides. When these spectra contain limited information, automated searches may lead to incorrect peptide identifications. It is therefore necessary to validate the identifications by careful manual inspection of the mass spectra. Not only is this task time-consuming, but the reliability of the validation varies with the experience of the analyst. Here, we report a systematic approach to evaluating peptide identifications made by automated search algorithms. The method is based on the principle that the candidate peptide sequence should adequately explain the observed fragment ions. Also, the mass errors of neighboring fragments should be similar. To evaluate our method, we studied tandem mass spectra obtained from tryptic digests of E. coli and HeLa cells. Candidate peptides were identified with the automated search engine Mascot and subjected to the manual validation method. The method found correct peptide identifications that were given low Mascot scores (e.g., 20-25) and incorrect peptide identifications that were given high Mascot scores (e.g., 40-50). The method comprehensively detected false results from searches designed to produce incorrect identifications. Comparison of the tandem mass spectra of synthetic candidate peptides to the spectra obtained from the complex peptide mixtures confirmed the accuracy of the evaluation method. Thus, the evaluation approach described here could help boost the accuracy of protein identification, increase number of peptides identified, and provide a step toward developing a more accurate next-generation algorithm for protein identification.
European Corpus Initiative (1992)

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Surface Characterization of Cholesterol Monohydrate Single Crystals by Chemical Force Microscopy (2002)

Atomic force microscopy (AFM) and chemical force microscopy (CFM) techniques have been used to characterize the chemical functionality of cholesterol monohydrate single-crystal surfaces in different solution environments. Both synthetic and natural crystals adopt a platelike habit in which the largest face is (001). Under aqueous and organic solution conditions, in situ contact mode topographical images reveal that the plate face is primarily terminated by bilayer molecular structures and therefore largely homogeneous. Adhesion force measurements obtained with chemically modified tips demonstrate that the functionality of the crystal surface can be altered by changes in the solution composition. The 3-hydroxyl end of cholesterol molecules is presented on the plate face in aqueous media, while alkyl tail groups terminate the surface in organic solutions. Contact angle measurements on (001) surfaces exposed to solvents of different hydrophilicity also show similar trends, providing additional support to these AFM assignments. These studies link molecular-level and macroscopic adhesion properties and demonstrate that solution environment can exert a strong influence on the surface properties of this important biomaterial.
Quantification of High-Molecular Weight Protein Platforms by AQUA Mass Spectrometry as Exemplified for the CD95 Death-Inducing Signaling Complex (DISC) (2013)

Contemporary quantitative mass spectrometry provides fascinating opportunities in defining the stoichiometry of high-molecular weight complexes or multiprotein platforms. The composition stoichiometry of multiprotein platforms is a key to understand the regulation of complex signaling pathways and provides a basis for constructing models in systems biology. Here we present an improved AQUA technique workflow that we adapted for the quantitative mass spectrometry analysis of the stoichiometry of the CD95 (Fas/APO-1) death inducing signaling complex (DISC). The DISC is a high-molecular weight platform essential for the initiation of CD95-mediated apoptotic and non-apoptotic responses. For protein quantification, CD95 DISCs were immunoprecipitated and proteins in the immunoprecipitations were separated by one-dimensional gel electrophoresis, followed by protein quantification using the AQUA technique. We will discuss in detail AQUA analysis of the CD95 DISC focusing on the key issues of this methodology, i.e., selection and validation of AQUA peptides. The application of this powerful method allowed getting new insights into mechanisms of procaspase-8 activation at the DISC and apoptosis initiation [1]. Here we discuss the AQUA methodology adapted by us for the analysis of the CD95 DISC in more detail. This approach paves the way for the successful quantification of multiprotein complexes and thereby delineating the intrinsic details of molecular interactions.
Extinction of Short A-C. Arcs (1931)

This paper presents the results of a study made with short, stationary a-c. arcs between metallic electrodes, in order to determine the effect of arc length, electrode material, and current magnitude on the rate of recovery of dielectric strength of the arc space following a current zero. The experimental results show (1) that the arc space recovers the ability to withstand a hundred volts or more within a few microseconds after a current zero, as predicted by Slepian's theory, (2) that the maximum allowable rate of rise of voltage across the arc space which will just permit arc extinction is much greater for very short arcs (1 cm. or less) than for longer arcs, (3) that the critical rate of rise of voltage depends largely on the electrode material used and tends to vary as a decreasing linear function of the boiling point, and (4) that the higher current arcs have a much lower critical rate of rise of voltage than the lower current arcs.
Rejoinder to: Pilkey, O.H.; Young, R. S.; Thieler, E. R.; Jacobs, B.S.; Katuna, M.P.; Lennon, G., and Moeller, M.E., 1996. (1998)

Reply to Houston, J.R. A Discussion of the Generalized Model for Simulating Shoreline Change (GENESIS). Journal of Coastal Research , 12(4), 1044-1050.
Self-assembly and gelation properties of novel peptides for biomedical applications (2013)

The self-assembly peptide hydrogels used as tissue culture scaffolds have drawn great attention in recent years. They have the advantages of natural polymer hydrogels including biocompatibility, biodegradability and the advantages of synthetic materials such as controlled structural properties and mechanical properties. Furthermore, the bioactive ligands which can promote bioactivities and control cell behaviours can be easily introduced to the peptide backbone through peptide synthesis. One particular self-assembly FEFEFKFK peptide was chosen in this project.FEFEFKFK peptide used in this project has been reported to self-assemble in solution, forming hydrogels with a 3D fibrous network structure above a critical gelation concentration. In this project, the self-assembly and gelation properties of FEFEFKFK peptide were further investigated, assessing the effect of pH and ionic strength on the self-assembly and gelation behaviour. The biomimetic nanofibrous hydrogels of FEFEFKFK were also assessed for their ability to support human dermal fibroblast cells. The protocols of gel preparation were developed for both 2 dimensional (2D) and 3 dimensional (3D) cell culture. A short peptide sequence homoarginine-glycine-aspartate (hRGD) has been introduced onto the amide end of the self-assembly peptide instead of bioactive ligand arginine-glycine-aspartate (RGD), creating hydrogels with a fibrous network with functionalised groups at the fibre surface. The functionalised peptide hydrogels enhanced cell adhesion on gel surface, with cell interaction assessed using various imaging and spectroscopic techniques. A preliminary 3D cell culture study also showed potential of these peptide gels to be used for encapsulated human dermal fibroblast cell studies.
The Zebrafish Embryo: A Powerful Model System for Investigating Matrix Remodeling (2009)

Extracellular matrix (ECM) remodeling is a process that is crucial to the development of embryos, the growth and metastasis of tumors, and wound healing and homeostasis of tissues in adults. As such, it involves dozens of gene products that are regulated by mechanisms operating at transcriptional and multiple posttranslational levels. This complexity of regulation has made the development of a comprehensive understanding of the biology of ECM remodeling in vivo an unusually challenging task, yet such an understanding would be of profound value to our knowledge of and clinical approaches to the treatment of many cancers. The primary effectors of ECM remodeling are the matrix metalloproteinases (MMPs). Homologs of this gene family have been identified in every metazoan examined. We propose that the zebrafish embryo is an ideal system for the study of the regulation of MMP activity, and we present some progress we have made in the development of this organism as a platform for MMP research. We have identified 25 genes encoding MMPs in the zebrafish genome, and 5 genes encoding their endogenous inhibitors, the tissue inhibitors of MMPs. Based on a phylogenetic analysis, we have identified the most probable homologies of these sequences and found that there are two that are of equivocal identity. We have developed 17 antibodies specific to zebrafish MMPs and have begun characterizing the ontogeny of these molecules. Finally, we have developed two novel assays that allow the detection and characterization of active MMPs in vivo (differential in vivo zymography and activity-based protease profiling). In combination with the array of powerful biochemical, genomic, cell, and molecular biological techniques available to zebrafish researchers already, we feel that these new reagents and techniques make the zebrafish the best model system for the study of MMP regulation currently available.
An Evaluation Process of Polymeric Adhesive Wafer Bonding for Vertical System Integration (2005)

Bonding of wafers using dielectric polymer thin films as bonding adhesives is one of key approaches to monolithic vertical system integration. As the first step for the integration, properties of the polymer desired for baseline adhesive material are studied, followed by the evaluations on bonding results obtained from wafer pairs bonded between a silicon and a glass wafers. Four sequential evaluation procedures are performed after bonding; (1) optical inspection is made to measure the fraction of bonded area, (2) a razor blade test is taken to separate the bonded wafers, (3) a four-point bending method is used to measure bonding strength quantitatively, (4) FTIR is applied to analyze changes in chemical structure. Bonding integrity is evaluated how the intentionally created debond areas of the bonded wafers are changed after the subsequent thinning processes. To date, benzocyclobutene (BCB), Flare TM , and methylsilsesquioxane (MSSQ) and Parylene-N have been considered as bonding adhesives. Among these polymer materials, BCB and Flare TM are selected as initial adhesive materials after a screening process through optical inspection. Wafer pairs bonded using Flare TM have higher bond strength than those using BCB. However, the bond strength of wafer pairs bonded using BCB is still higher than that at the interface between Cu and porous low- k inter-level dielectrics (ILD) (a back end interconnect structure), indicating almost 100% of bonded area reproducibly. In the light of such evaluation results, BCB has been eventually selected as a baseline adhesive material for the wafer bonding prcess for vertical system integration.
The Capstone Turbogenerator as an Alternative Power Source (1997)

<div class="htmlview paragraph">A 30kW Turbogenerator has been developed by Capstone Turbine Corp and tested for use in both stationary and vehicular power applications. Low emissions are achieved without aftertreatment. This compact (18 inch diameter) lightweight (165 pound) microturbine integrates turbomachinery and an electric generator on a single shaft assembly -- the only moving part of the engine. The rotor is mounted on air bearings, which require no oil or other lubrication. The turbogenerator is air-cooled; it has no liquid coolants and needs no radiator or other auxiliary coolers.</div> <div class="htmlview paragraph">Test units have accumulated over 10,000 hours. Originally predicted design-point power output has been exceeded, and design point thermal efficiency closely approached. On a sea-level, 35 degree Celsius day, the turbogenerator has demonstrated in excess of 24kW at 29 percent thermal efficiency. The unit is currently undergoing field testing, both stationary and mobile, over its entire power range. Mobile testing is aimed primarily at application to hybrid electric vehicles.</div>
Assessing unknown network traffic (2004)

Recent measurements have shown that a growing fraction of all Internet traffic is unknown: it is unclear which applications are causing the traffic. Therefore we have developed and applied a novel methodology to find out what applications are running on the network. This methodology is based on the notion of ?induced traffic?: traffic cannot (wide-scale) be on unknown ports, thus, 
the hypothesis is that such traffic on unknown ports should be preceeded by traffic on known ports between the same peers. We have developed and implemented an algorithm to test this hypothesis. After applying the algorithm in two case studies we, unfortunately, have to conclude that although some improvement is made, there is still a significant fraction of traffic unidentifiable.
SHAPING IN THE 21ST CENTURY: MOVING PERCENTILE SCHEDULES INTO APPLIED SETTINGS (1994)

The present paper provides a primer on percentile reinforcement schedules, which have been used for two decades to study response differentiation and shaping in the laboratory. Arranged in applied settings, percentile procedures could be used to specify response criteria, standardizing treatment across subjects, trainers, and times to provide a more consistent training environment while maintaining the sensitivity to the individual's repertoire that is the hallmark of shaping. Percentile schedules are also valuable tools in analyzing the variables of which responding is a function, both inside and outside the laboratory. Finally, by formalizing the rules of shaping, percentile schedules provide a useful heuristic of the processes involved in shaping behavior, even for those situations that may not easily permit their implementation. As such, they may help further sensitize trainers and researchers alike to variables of critical importance in behavior change.
Anticonvulsant Activity of Antiparkinsonism Agents (1968)

The anticonvulsant activity of synthetic antiparkinsonism agents has been studied in mice with experimental seizures and in children with myoclonic spasms refractory to conventional medications. Procyclidine and trihexyphenidyl protected mice from maximal electroshock seizures. Procyclidine was the more potent compound and was also effective against pentylenetetrazol seizures. In a preliminary, short-term clinical trial, procyclidine caused a reduction in the incidence of seizures in 10 of 16 patients treated. The antiparkinsonism agents are free of severe chronic toxicity and are contraindicated only in adults with glaucoma or urethral obstruction. Further laboratory and clinical investigation of the anticonvulsant activity of this class of compounds is recommended.
Usefulness of Skin Hydration for Skin Care and Development of Cosmetics. (2002)

保湿は肌荒れに対して大変有効な手段であり, また化粧品の最も基本的かつ重要な機能と考えられる。そして多くの種類のエモリエント剤や保湿剤が皮膚の水分保持や乾燥を防御することを目的として用いられてきた。角質層においては, 自然保湿成分 (NMF), 皮脂および細胞間脂質の重要性が証明されてきた。皮膚科学的なアプローチの観点からわれわれは皮膚保湿のメカニズムのアナロジーを皮膚上で再構築してきた。具体的には肌荒れに対して, 水, 保湿剤および脂質を等価に皮膚に補う“モイスチャーバランス”の有用性を証明してきた。これらとは別に化粧品の開発に薬理学的なアプローチの観点も重要であり, 新規な化粧品有効成分の開発に大変役に立つ方法論である。近年われわれは, 肌荒れにおいて表皮プロテアーゼが重要な役割を果たすこと, またその活性を阻害することが修復を促すことを明らかにしてきた。そして表皮プロテアーゼであるプラスミンの阻害活性を有し, 肌荒れに効果を有するt-AMCHAを開発した。本総説では, 皮膚の保湿のメカニズムと, 皮膚科学的にまた薬理学的に開発されたスキンケア化粧品についてレビューする。
Activation of Superficial Dorsal Horn Neurons in the Mouse by a PAR-2 Agonist and 5-HT: Potential Role in Itch (2009)

Itch, an unpleasant sensation associated with the desire to scratch, is symptomatic of dermatologic and systemic disorders that often resist antihistamine treatment. Histamine-independent itch mediators include serotonin (5-HT) and agonists of the protease-activated receptor-2 (PAR-2). We used behavior, Fos immunohistochemistry, and electrophysiology to investigate if these mediators activate spinal dorsal horn neurons in a manner consistent with itch. Intradermal (i.d.) injection of the PAR-2 agonist SLIGRL-NH(2) in the rostral back evoked bouts of directed hindlimb scratches over 20-30 min. Hindpaw injection of SLIGRL-NH(2) produced Fos staining in superficial dorsal horn which was then targeted for single-unit recording. Small id microinjections of SLIGRL-NH(2) or 5-HT identified responsive single units in the superficial dorsal horn of mice anesthetized with pentobarbital. Thirty-eight units characterized as wide dynamic range, nociceptive specific, or mechanically insensitive exhibited significantly increased firing after i.d. SLIGRL-NH(2) for 9 min, to partial (25%) tachyphylaxis with repeated injection. A majority additionally responded to 5-HT (70%), mustard oil (79%), and capsaicin (71%). Seven units isolated with the 5-HT search stimulus exhibited significant and prolonged responses to 5-HT with tachyphylaxis to repeated injections. The majority also responded to SLIGRL-NH(2), mustard oil, and capsaicin. The prolonged responses of superficial dorsal horn neurons to SLIGRL-NH(2) and 5-HT suggest a role in signaling itch. However, their responsiveness to algogens is inconsistent with itch specificity. Alternatively, such neurons may signal itch, whereas noxious stimulus levels recruit these and a larger population of pruritogen-insensitive cells to signal pain which masks or occludes the itch signal.
Safety and Efficacy of AGN-190584 in Individuals With Presbyopia (2022)

ClinicalTrials.gov Identifier: NCT03804268.
Dissociation Constants of Organic Boric Acids (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDissociation Constants of Organic Boric AcidsBernard Bettman, G. E. K. Branch, and David L. YabroffCite this: J. Am. Chem. Soc. 1934, 56, 9, 1865–1870Publication Date (Print):September 1, 1934Publication History Published online1 May 2002Published inissue 1 September 1934https://pubs.acs.org/doi/10.1021/ja01324a012https://doi.org/10.1021/ja01324a012research-articleACS PublicationsRequest reuse permissionsArticle Views493Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Redox Regulatory Mechanisms in Cellular Stress Responses (2006)

Redox regulatory mechanisms are intricately embedded in both the cytoplasmic and endoplasmic reticulum stress responses at multiple levels. Many different stimuli, both internal and external, activate endogenous production of reactive oxygen species as a necessary part of the intracellular communication system that activates stress responses.
[Fishing seawater microbiology of the Mar de Plata]. (1976)

This work deals with different groups of microorganisms in the polluted water of the fishery section of Mar del Plata harbour and in the way followed by the fisher's boats. Bacteriological determinations were: total count, MPN of coliforms, proteolitic and anaerobic bacteria. These groups were selected because of their activity in fish spoilage and/or infection. The microbial groups were studied as follows: direct plate count for total number, most probable number (MPN) for coliforms and fecal type strains according with Mc Crady tables; proteolitic and anaerobic bacteria were cualitatively tested, cuantitative determinations are given in two tables. Obtained results show a heavy water pollution that rapidly decreases towards the harbour entrance.
Laboratory applications of ion exchange techniques. (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaboratory applications of ion exchange techniques.Edward. R. Tompkins Cite this: J. Chem. Educ. 1949, 26, 1, 32Publication Date (Print):January 1, 1949Publication History Received3 August 2009Published online1 January 1949Published inissue 1 January 1949https://doi.org/10.1021/ed026p32RIGHTS & PERMISSIONSArticle Views168Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (6 MB) Get e-Alerts Get e-Alerts