gebhart/patrepeval huggingface dataset:
The effects of lead and nickel ions on total proteins and metallothioneins synthesis in mice liver (2014)

The present study was conducted to investigate the effects of lead and nickel ions on total proteins and metallothioneins synthesis in mice liver. Lead (Pb) is a heavy metal used in a wide variety of consumer products and occupational settings. Nickel (Ni) is a ubiquitous metal element found in a wide variety of compounds. The protein synthesis is the process by which biological cells generate new proteins. Metallothioneins (MTs) are a group of small proteins found in the cytosol of cells, particularly of liver, kidney, and intestine. Experiments were done on 4–6 weeks old white laboratory outbreed mice weighing 20–25 g. Concentration of protein was determined by Lowry method. MTs were assayed in mice liver according to Peixoto method. There are no statistically significant changes in lead group after 14 days experiment. After 14 days of injections of NiCl2 solution, marked amino acid actuation to new synthesized protein has increased by 57%, in mice liver treated with Pb(CH3COO)2 MTs content was increased by 57% compared with control. In mice liver treated with NiCl2 MTs content was increased by 55% compared with control. There is no statistically significant effect of lead on protein synthesis in mice liver. According to the data, injections of NiCl2 solution marked amino acid actuation to new synthesized proteins has increased. The obtained data showed that in mice liver treated with NiCl2 and Pb(CH3COO)2 solutions MTs content was increased.
The Epstein-Barr Virus SM Protein Is Functionally Similar to ICP27 from Herpes Simplex Virus in Viral Infections (2002)

The herpes simplex virus type 1 (HSV-1) ICP27 protein is an essential RNA-binding protein that shuttles between the nucleus and cytoplasm to increase the cytoplasmic accumulation of viral late mRNAs. ICP27 homologs have been identified in each of the herpesvirus subfamilies, and accumulating evidence indicates that homologs from the gammaherpesvirus subfamily function similarly to ICP27. In particular, the Epstein-Barr virus (EBV) SM protein posttranscriptionally regulates gene expression, binds RNA in vitro and in vivo, and shuttles between the nucleus and cytoplasm. To determine if these two proteins function through a common mechanism, the ability of EBV SM to complement the growth defect of an HSV-1 ICP27-null virus was examined in a transient-expression assay. ICP27 stimulated the growth of the null mutant more efficiently than did SM, but the ability of SM to compensate for the ICP27 defects suggests conservation of common functions. To assay for complementation in the context of a viral infection, the growth properties of an HSV recombinant expressing SM in an ICP27-null background were analyzed. SM stimulated growth of the recombinant, although this growth was reduced by comparison to that of an ICP27-expressing virus. By contrast, an HSV recombinant expressing an SM mutant allele defective for transactivation activity and nucleocytoplasmic shuttling did not grow at all. These results suggest that SM and ICP27 may regulate gene expression through a common pathway that is evolutionarily conserved in herpesviruses.
Avaluació de portaempelts de tomàquet per al control de Meloidogyne javanica (2008)

Ha guanyat la segona edicio del Premi Claudi Barbera atorgat per la Institucio Catalana d’Estudis Agraris (filial de l’IEC) l'any 2008.
Stress‐enhanced dislocation density reduction in multicrystalline silicon (2010)

Abstract Stress is generally perceived to be detrimental for multicrystalline silicon (mc‐Si), leading to dislocation multiplication during crystal growth and processing. Herein, we evaluate the role of stress as a driving force for dislocation density reduction in mc‐Si. At high temperatures, close to the melting point (>0.8 T m ), we observe that the application of stress as well as the relief of residual stress, can modify the density of pre‐existing dislocations in as‐grown mc‐Si under certain conditions, leading to a net local reduction of dislocation density. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Process Temperature-Hardness-Wear Relationships for HVOF-Sprayed Nanostructured and Conventional Cermet Coatings (2003)

Abstract High velocity oxy-fuel spraying of WC-12Co was performed using a feedstock in which the WC phase was either principally in the micron size range (conventional) or was engineered to contain a significant fraction of nanosized grains (multimodal). Three different HVOF systems and a wide range of spray parameter settings were employed to study the effect on both the in-flight particle characteristics and coating properties. A process window with respect to particle temperature was identified for producing coatings with the highest resistance to dry abrasion. Although the presence of a nanosized WC phase produced harder coatings, there was little difference in the abrasion resistance of the best-performing conventional and multimodal coatings. However, there is a potential benefit in using the multimodal feedstock because of the possibility of higher deposition efficiencies and a more robust thermal spray process.
The Fate of the Oxidizing Tyrosyl Radical in the Presence of Glutathione and Ascorbate (1998)

Cellular systems contain as much as millimolar concentrations of both ascorbate and GSH, although the GSH concentration is often 10-fold that of ascorbate. It has been proposed that GSH and superoxide dismutase (SOD) act in a concerted effort to eliminate biologically generated radicals. The tyrosyl radical (Tyr.) generated by horseradish peroxidase in the presence of hydrogen peroxide can react with GSH to form the glutathione thiyl radical (GS.). GS. can react with the glutathione anion (GS-) to form the disulfide radical anion (GSSG-). This highly reactive disulfide radical anion will reduce molecular oxygen, forming superoxide and glutathione disulfide (GSSG). In a concerted effort, SOD will catalyze the dismutation of superoxide, resulting in the elimination of the radical. The physiological relevance of this GSH/SOD concerted effort is questionable. In a tyrosyl radical-generating system containing ascorbate (100 microM) and GSH (8 mM), the ascorbate nearly eliminated oxygen consumption and diminished GS. formation. In the presence of ascorbate, the tyrosyl radical will oxidize ascorbate to form the ascorbate radical. When measuring the ascorbate radical directly using fast-flow electron spin resonance, only minor changes in the ascorbate radical electron spin resonance signal intensity occurred in the presence of GSH. These results indicate that in the presence of physiological concentrations of ascorbate and GSH, GSH is not involved in the detoxification pathway of oxidizing free radicals formed by peroxidases.
Overexpression of the Tumor Autocrine Motility Factor Receptor Gp78, a Ubiquitin Protein Ligase, Results in Increased Ubiquitinylation and Decreased Secretion of Apolipoprotein B100 in HepG2 Cells (2003)

Apolipoprotein B100 (apoB) is a large (520-kDa) complex secretory protein; its secretion is regulated posttranscriptionally by several degradation pathways. The best described of these degradative processes is co-translational ubiquitinylation and proteasomal degradation of nascent apoB, involving the 70- and 90-kDa heat shock proteins and the multiple components of the proteasomal pathway. Ubiquitinylation involves several proteins, including ligases called E3s, that coordinate the covalent binding of ubiquitin to target proteins. The recent discovery that tumor autocrine motility factor receptor, also known as gp78, is an endoplasmic reticulum (ER)-associated E3, raised the possibility that this E3 might be involved in the ER-associated degradation of nascent apoB. In a series of experiments in HepG2 cells, we demonstrated that overexpression of gp78 was sufficient for increased ubiquitinylation and proteasomal degradation of apoB, with reduced secretion of apoB-lipoproteins. This action of gp78 was specific: overexpression of the protein did not affect secretion of either albumin or apolipoprotein AI. Furthermore, overexpression of a cytosolic E3, Itch, had no effect on apoB secretion. Finally, using an in vitro translation system, we demonstrated that gp78 led to increased ubiquitinylation and proteasomal degradation of apoB48. Together, these results indicate that an ER-associated protein, gp78, is a bona fide E3 ligase in the apoB ER-associated degradation pathway.
N-doped Titania Thin Films, Prepared by Atmospheric Pressure Chemical Vapour Deposition: Enhanced Visible Light Photocatalytic Activity and Anti-microbial Effects (2009)

Titanium dioxide (TiO2) films have been highly commercialized as photocatalyst coatings with applications in technologies such as self-cleaning glass. There is however interest in developing superior coatings that operate under domestic lighting conditions for cleaning and anti-microbial applications in healthcare environments. One such approach to improve on TiO2 is to shift the band-gap from UV into the visible region of the spectrum, thus harvesting a greater proportion of solar energy and allowing the films to work under indoor-lighting conditions. This paper shows an example of the selective doping of TiO2 with beneficial results in the quest for visible light photocatalyst with anti-microbial properties.
Increased expression of Gallicin 11 in chicken ovarian cancer (2010)

Gallicin 11, also known as beta-defensin 11, is a member of the chicken beta-depensin family and constitutes a vitellin membrane outer layer of egg yolk. The protein is an essential component of innate immunity and acts in the antimicrobial process by disrupting the membrane integrity of microbes. However, it has yet to be investigated that expression and functional role of Gallicin 11 in chickens with ovarian cancer. Therefore, the purpose of this study was to investigate the changes of Gallicin 11 expression in chicken with ovarian cancer in order to understand the mechanism(s) responsible for the etiology and development of ovarian cancer in chickens. In the current study, we performed RT-PCR, quantitative RT-PCR, and in situ hybridization analyses to determine the expression, quantitation and localization of Gallicin 11 mRNA in normal and cancerous chicken ovaries. The results showed that Gallicin 11 mRNA level is highly increased in the cancerous ovarian tissue compared to the normal ovary. Interestingly, Gallicin 11 mRNA is particularly abundant in gland area of ovarian cancer tissue but not in other cell-types such as stroma and connective tissues in the oviduct. Our results suggest that Gallicin 11 has important functions in the development of epithelial ovarian cancer and provide the basis for understanding the mechanism(s) responsible for the development of ovarian cancer in chickens.
Developmental changes in neural progenitor cell lineage commitment do not depend on epidermal growth factor receptor signaling (2000)

Multipotent neural progenitor cells become progressively more biased towards a glial fate during development coincident with an increase in expression of the epidermal growth factor receptor (EGFR). To determine whether differences in lineage commitment of neural progenitor cells from different stages are causally related to expression of the EGFR and whether generation of glia is EGFR-dependent, we used an EGFR-specific tyrosine kinase inhibitor, PD158780, to block the activation of EGFR in progenitor cells. Treatment of cultured neonatal progenitor cells with PD158780 completely blocked EGF-induced proliferation of the cells but did not affect bFGF-induced proliferation. Nevertheless, treatment with the inhibitor failed to inhibit the generation of astroglia in the presence of either EGF or bFGF. Treatment with bone morphogenetic protein-2 (BMP2) enhanced astroglial differentiation and suppressed oligodendroglial (OL) differentiation. PD158780 treatment had no effect on the BMP2-induced astroglial differentiation or OL suppression. These observations suggest that the generation of astroglia is not dependent on EGFR activation. Because it was still possible that the progenitor cell responses reflected a prior history of EGFR signaling, rat forebrain cells were cultured in the presence of PD158780 from a time (E12.5) preceding expression of the EGFR. After time in culture, the E12.5 cells expressed EGFR by Western analysis both in the presence and in the absence of PD158780, but activation of EGFR kinase (receptor autophosphorylation) was undetectable in the presence of PD158780 and the cells did not proliferate in response to EGF. Nevertheless, astroglial differentiation was normal in PD158780-treated cells both in the absence and in the presence of BMPs or CNTF. Furthermore, the propensity towards glial differentiation increased with time in culture even in the absence of EGFR signaling. This suggests that the increased bias towards glial differentiation during development does not depend on EGFR signaling.
Rate-distortion with common rate-limited side information to the encoder and decoder (2008)

We consider a family of problems involving source coding in the presence of limited-rate side information. We give complete single-letter characterizations of the fundamental limits for these problems. We also work out the explicit form of these fundamental limits for specific cases such as Gaussian and binary sources.
Convergent Cyclopentannelation Process (2003)

[reaction: see text] A triply convergent synthesis of alpha-methylene cyclopentenones has been demonstrated in which an intermediate C,O-dianion is formed and trapped on carbon by electrophiles.
INVESTIGATION OF THE SELF INCOMPATIBILITY MECHANISM IN CLEMENTINE (CITRUS CLEMENTINE HORT. EX TAN.) USING CDNA-AFLP (2012)

ISHS XXVIII International Horticultural Congress on Science and Horticulture for People (IHC2010): International Symposium on Genomics and Genetic Transformation of Horticultural Crops INVESTIGATION OF THE SELF INCOMPATIBILITY MECHANISM IN CLEMENTINE (CITRUS CLEMENTINE HORT. EX TAN.) USING CDNA-AFLP
Provision of MBMS over the GERAN: technical solutions and performance (2004)

3GPP is currently in the process of standardising Multimedia Broadcast and Multicast Services (MBMS). The technical solutions adopted for the provision of these services over the GERAN (GSM/EDGE radio access network) A/Gb mode are presented. Simulation results are provided showing the data rates that can be achieved over the radio interface using the data transfer mechanisms already available in Release 5. Some of the concepts (to be included as part of Release 6) that have been proposed in 3GPP to increase the data rates, such as outer coding in the RLC layer or point-to-multipoint (p-t-m) with feedback, are also discussed, and their performance gain demonstrated through simulations.
A new method for accurate co-registration of interferometric SAR images (1998)

This paper presents a new approach for accurate co-registration in range or azimuth direction of interferometric SAR images. The method is intrinsically very accurate and effective since it does not use any interpolation or cross-correlation procedure as in conventional methods. Results obtained with interferometric airborne data are presented showing that a co-registration accuracy better than 0.03 of a sample is achieved for a window of 32 times 32 samples.
NOTE Uncertain Reasoning and Learning for Feature Grouping 1 (1999)

Perceptual organization of low-level features that can be extracted immediately from images into object level descriptions is a key task in computer and human perception processes. Per-ceptual organization techniques have been a persistent topic of
Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling (2019)

Ivermectin, as a promising anti-cancer agent, inhibits the growth of canine mammary tumor by regulating cell cycle progression and WNT signaling.
Class-E amplifiers and applications at MF, HF, and VHF (2017)

Class E amplifiers have been used in a very broad frequency range. This paper expose a general review of the basic application of class E amplifiers for lower frequencies (MF, HF, VHF), including typical components, applications, and results.
Eyelid cancers (1998)

Eyelid cancers, like most malignancies, are on the rise, creating an ever-enlarging population of patients with these diseases. Trends in eyelid cancer diagnosis, prognostic evaluation, prevention, and management are reviewed. Special emphasis is placed upon understanding perineural invasion by squamous cell carcinoma, the role of genetic mutations in eyelid cancer development and prognosis, and new techniques for total upper eyelid reconstruction.
Executable misuse cases for modeling security concerns (2008)

Misuse cases are a way of modeling negative requirements, that is, behaviors that should not occur in a system. In particular, they can be used to model attacks on a system as well as the security mechanisms needed to avoid them. However, like use cases, misuse cases describe requirements in a high-level and informal manner. This means that, whilst they are easy to understand, they do not lend themselves to testing or analysis. In this paper, we present an executable misuse case modeling language which allows modelers to specify misuse case scenarios in a formal yet intuitive way and to execute the misuse case model in tandem with a corresponding use case model. Misuse scenarios are given in executable form and mitigations are captured using aspect-oriented modeling. The technique is useful for brainstorming potential attacks and their mitigations. Furthermore, the use of aspects allows mitigations to be maintained separately from the core system model. The paper, supported by a UML-based modeling tool, describes an application to two case studies, providing evidence that the technique can support red-teaming of security requirements forn realistic systems.
Efficient implementation of the spectral division method for arbitrary virtual sound fields (2013)

The Spectral Division Method is an analytic approach for sound field synthesis that determines the loudspeaker driving function in the wavenumber domain. Compact expressions for the driving function in time-frequency domain or in time domain can only be determined for a low number of special cases. Generally, the involved spatial Fourier transforms have to be evaluated numerically. We present a detailed description of the computational procedure and minimize the number of required computations by exploiting the following two aspects: 1) The interval for the spatial sampling of the virtual sound field can be selected for each time-frequency bin, whereby low time-frequency bins can be sampled more coarsely, and 2) the driving function only needs to be evaluated at the locations of the loudspeakers of a given array. The inverse spatial Fourier transform is therefore not required to be evaluated at all initial spatial sampling points but only at those locations that coincide with loudspeakers.
Le principe de simplicité des voies dans la seconde moitié du XVIIe siècle (1995)

Het beginsel van de eenvoud van de wegen in de tweede helft van de XVIIIe eeuw. De bedoeling is het zowel wetenschappelijke als filosofische beginsel van de eenvoud van de wegen, zoals dat bij Malebranche opduikt, te analyseren door een vergelijking met de Cartesiaanse gedachte van de eenvoudige operatie en anderzijds met de opvatting van Leibniz over het determinatieprincipe. Die confrontatie toont de veranderingen die eenzelfde principe kan ondergàan tijdens de overgang van het wetenschappelijke domein naar een ander : mechanica, optica en geométrie.
Microbiological desulfurization of coal and its increased monetary value (1986)

The basis for commercialization of a microbial process for coal desulfurization has been established and is effective on a variety of bituminous coals and lignite. Different mixtures of organisms are used for removal of pyritic sulfur and inorganic sulfur. It will be possible to develop a two stage process for removal of both forms of sulfur, and the technology for each stage would be similar. It is possible to remove over 90% of pyritic sulfur in addition to minerals equivalent to 5 to 10% of the raw coal weight (ash equivalent) without significant loss of Btu's. The microbial process can remove finely dispersed pyrite that resists removal via conventional cleaning procedures. Both mesophilic (15-40 C) and thermophilic (above 50 C) temperature ranges are available, although there are insufficient comparative data to adequately assess advantages and disadvantages of each. Organic sulfur tends to be present in much lower amounts and various experiments show that between 21% and 63% of the organic sulfur content can be removed from specific coal samples. Users have been paying a premium for low sulfur, equivalent to 5 to 35 dollars per 1% sulfur per ton, with lowest sulfur content attracting the highest premium. The premium paid is sufficient to cover the estimated cost of microbial desulfurization. 37 references.
Amiloride inhibits mammalian renal kallikrein and a kallikrein-like enzyme from toad bladder and skin. (1980)

Renal kallikrein is localized in luminal plasma membranes of the mammalian distal nephron and gains access to urine from this site. Its activity is regulated, in part, by aldosterone. These facts led us to study the effects of amiloride, a drug known to inhibit sodium reabsorption and potassium secretion at this site, on kallikrein activity. Amiloride inhibited the esterolytic activity of purified rat or human urinary kallikrein or of rat renal cortical cells upon a synthetic substrate (ID50 = 0.12-0.23 mM). Kinetic analyses showed that the enzyme inhibition was noncompetitive and reversible in nature. The kinin-generating activity of kallikrein acting upon kininogen substrates was also inhibited by amiloride, as measured by bioassay in the rat uterus of guinea pig ileum or by radioimmunoassay of liberated kinins (ID50 = 85 microM). No other diuretic drug tested inhibited kallikrein activity, except triamterene, which did so, weakly. In addition, kallikrein-like enzyme activity was discovered in the urinary bladder or skin of Bufo marinus toads and this activity was also inhibited by amiloride. The localization of the enzyme and its inhibition by this drug suggest that further study of relationships amongst the glandular kallikrein-kinen system and renal ion and water transport is warranted.
Simulation and control of SMA actuators (1999)

A one-dimensional model for shape memory alloys is presented that permits the simulation of actuatoric behavior. It is an improved version of the Muller-Achenbach single crystal model and calculates the length change as a response to electric heating. Based on this model, a polycrystalline version is developed, which is shown to be in excellent agreement with experimental results. Finally, as an illustrative application, a real-time control is calculated for an adaptive beam using SMA actuators.
Centralisateurs d’operateurs pseudo-differentiels formels a coefficients constants (1987)

Nous introduisons la notion de déterminant différentiel de Hankel qui nous permet de caractériser les opérateurs pseudo-différentiels formels qui sont rationnels. Puis dans ub. deuxième temps, nous étudions la structure des centralisateurs des opéra-teurs pseudo-différentiels formels à coefficients constants.