gebhart/patrepeval huggingface dataset:
Epulis presenting as congenital multiple polypoidal oral mass lesion: A surprising case report (2017)

A newborn infant with congenital epulis (CE) can be a striking miserable sight for both parents and health care professionals involved in neonatal care. These tumours of the infant mouth can be remarkably large, occupying much of the oral cavity and posing a risk of airway obstruction or interfering with feeding with marked facial deformity. Neumann first described congenital epulis of newborn in 1871. It is most frequently located on the anterior maxillary alveolar ridge with slight female predilection. It clinically appears as a pedunculated protuberant mass. In cases with large lesions, mechanical oral and nasal obstruction can impair fetal deglutition and neonatal respiratory efforts resulting in polyhydramnios prenatally or respiratory impairment postnatally. Histologically Congenital epulis shows characteristic large cells with granular cytoplasm and spindle cells resembling fibroblasts. The exact histogenesis is still uncertain, various theories of origin are epithelial, undifferentiated mesenchymal cells, pericytes, fibroblast, smooth muscle cells and nerve related cells. Herein we report a newborn female child with Multiple Congenital epulis arising from maxilla and mandible with investigation, management and follow-up.
Abstract 1587: Conditional Overexpression of the Oncogene c-Myc Produces Hypertrophic Cardiomyopathy and Results in Mitochondrial Dysfunction at Complex I (2008)

c-Myc is transiently expressed early during cardiac pressure overload, but its pathological role is unclear. To address the contribution of c-myc in the genesis of cardiomyopathy, we established a tetracycline-inducible, cardiomyocyte-specific, c-myc-overexpressing bitrans-genic mouse. Doxycyline treatment (DOX) for 2 weeks (Myc-ON, n=5) increased cardiac mass two-fold with myocyte disarray, and increased fiber width and fibrosis compared to control mice (Myc-OFF, n=8); LV fractional shortening (15MHz, Sequoia, Siemens) was less (0.28±0.03(SEM) vs.0.53±0.04) and myocardial performance index was greater (0.91±0.15 vs. 0.36±0.03, both p<0.05) indicating ventricular dysfunction in Myc-ON vs. Myc-OFF. Death resulted from irreversible heart failure. The cell cycle markers PCNA, Ki-67 and cyclin D1 were strongly induced and BrdU incorporation confirmed cell cycle progression to S-phase. To determine if mitochondrial dysfunction contributed to the cardiomyopathy of c-Myc-overexpression, oxidative phosphorylation (OXPHOS) was studied with glutamate/malate (complex I), succinate (complex II) and TMPD-ascorbate (complex IV) as substrates. OXPHOS decreased with glutamate/malate (213±40 vs.329±25 nAO/min/mg, p<0.05) after two weeks of Myc-ON (n=4) vs. control (n=4), but was unaltered with other substrates, localizing a defect to complex I of the electron transport chain. The complex I defect was confirmed by a decrease in NADH:decylubiquinone oxidoreductase activity (561±49 vs.752±38 mU/mg). PGC-1a (a major regulatory mechanism of mitochondrial proliferation) was increased in Myc-ON, and ultrastructural analysis revealed a 2.5-fold increase in mitochondrial number, possibly in response to the OXPHOS defect. Taken together, these findings suggest: cardiac restricted temporally-defined Myc overexpression turns on cell cycle machinery in cardiomyocytes and produces decompensated hypertrophic cardiomyopathy; and activation of c-Myc leads to an OXPHOS defect at complex I. Since complex I defects impair energy production and increase the production of reactive oxygen species, we speculate that mitochondrial dysfunction contributes to the cardiomyopathy that develops when adult cardiomyocytes overexpress c-Myc.
Cyclic Polyolefins. XXXVI. trans-Cyclononene and trans-Cyclodecene from Cyclononyldimethylamine Oxide and Cyclodecyldimethylamine Oxide (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic Polyolefins. XXXVI. trans-Cyclononene and trans-Cyclodecene from Cyclononyldimethylamine Oxide and Cyclodecyldimethylamine OxideArthur C. Cope, Donald C. McLean, and Norman A. NelsonCite this: J. Am. Chem. Soc. 1955, 77, 6, 1628–1631Publication Date (Print):March 1, 1955Publication History Published online1 May 2002Published inissue 1 March 1955https://pubs.acs.org/doi/10.1021/ja01611a066https://doi.org/10.1021/ja01611a066research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improved Output Power of GaN-based Blue LEDs by Forming Air Voids on Ar-Implanted Sapphire Substrate (2013)

This paper investigates GaN-based blue light-emitting diodes (LEDs) grown on sapphire substrates with selective-area Ar-ion implantation. The GaN-based epitaxial layers grown on the Ar-implanted sapphire substrates (Ar-ISS) exhibited selective growth and subsequent lateral growth because of different lattice constants between the implantation and implantation-free regions. As a result, air voids were formed at the GaN/sapphire interface, above the implanted regions and below the active layers of LEDs. We proposed the GaN layer growth mechanisms on the Ar-ISS, and characterized the LEDs with embedded air voids at the GaN/sapphire interface. Using a 20-mA current injection, the light output of the experimental LEDs was found to be 15% greater than that of conventional LEDs. This enhancement can be attributed to the light scattering at the textured GaN/air void interfaces, which increases the probability of photons escaping from the LEDs.
The cell surface (1992)

This volume contains abstracts of oral presentations and poster sessions of made at the LVII Cold Springs Symposium on Quantitative Biology, entitled The Cell Surface.
Symbiotic Growth of Pleuropneumonia-iike Organisms with Bacterial Colonies (1949)

Nine of 14 strains of PPLO of human origin and one strain of rat origin were observed to grow on beef heart infusion agar without ascitic fluid or serum only in symbiosis with Staphylococcus albus and all 15 strains grew in symbiosis with Proteus vulgaris.
<b>Donor Properties of Sulfoxides, Alkyl Sulfites, and Sulfones</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDonor Properties of Sulfoxides, Alkyl Sulfites, and SulfonesRussell S. Drago, Bradford. Wayland, and Robert L. CarlsonCite this: J. Am. Chem. Soc. 1963, 85, 20, 3125–3128Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ja00903a016https://doi.org/10.1021/ja00903a016research-articleACS PublicationsRequest reuse permissionsArticle Views606Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pica With Paradichlorobenzene Mothball Ingestion Associated With Toxic Leukoencephalopathy (2006)

This is a case report of central nervous system toxicity associated with paradichlorobenzene (PDCB) ingestion. The patient had ingested mothballs composed of 99.99% PDCB for a period of 7 months. She was admitted for depression and had no neurologic symptoms. Later she developed an acute cerebellar syndrome followed by stupor and coma. An extensive workup was negative except for decreasing levels of PDCB in her serum. Imaging revealed a diffuse leukoencephalopathy. Her clinical picture was attributed to PDCB toxicity.
Concurrent FM-CW Radar and Lidar Observations of the Boundary Layer (1974)

Boundary layer probing by multiple remote sensors can greatly improve the understanding of processes in this complex region. For this purpose one needs to know the unique information each individual sensor can provide. Two promising boundary layer remote sensors, a microwave, frequency-modulated, continuous-wave (FM-CW) radar and a laser radar (lidar), were operated simultaneously to probe a common volume. As expected, the lidar sometimes separately detected aerosol layers, notably cloud bases, and the radar sometimes separately detected refractive layers and insects. Boundaries of aerosol structures were often found to be regions of radar returns such as in layers, convective activity, and breaking waves. In contrast, however, a refractive layer was observed within an apparently well-mixed aerosol layer. The data indicate that the radar may have a characteristic echo which is coincident with cloud and fog tops. This experiment shows that FM-CW radars and lidars can separately sense layering in the boundary region and that they provide complementary information on boundary layer mixing processes.
Formal verification of algorithms for critical systems (1993)

The authors describe their experience with formal, machine-checked verification of algorithms for critical applications, concentrating on a Byzantine fault-tolerant algorithm for synchronizing the clocks in the replicated computers of a digital flight control system. The problems encountered in unsynchronized systems and the necessity, and criticality, of fault-tolerant synchronization are described. An overview of one such algorithm and of the arguments for its correctness are given. A verification of the algorithm performed using the authors' EHDM system for formal specification and verification is described. The errors found in the published analysis of the algorithm and benefits derived from the verification are indicated. Based on their experience, the authors derive some key requirements for a formal specification and verification system adequate to the task of verifying algorithms of the type considered. The conclusions regarding the benefits of formal verification in this domain and the capabilities required of verification systems in order to realize those benefits are summarized.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interaction between the erythromycin and chloramphenicol binding sites on the Escherichia coli ribosome (1977)

The effects of chloramphenical on the binding kinetics of a fluorescein isothiocyanate derivative of 9(S)-erythromycylamine with 70S and 50S ribosomes have been studied by direct fluorimetric measurements. While chloramphenicol had little effect on the second-order 70S binding rate of the erythromycin analogue, it substantially reduced the dissociation rate of the fluorescent antibiotic-70S ribosome complex. This could be explained by simultaneous binding of both antibiotics to the 70S ribosome. The kinetic results suggest that chloramphenicol-saturated 70S particles bind the erythromycin analogue four times stronger and this was confirmed by direct binding studies. In additon, chloramphenicol causes a twofold increase in the intrinsic fluorescence of the 70S-bound analogue. This increase in fluorescence was used to study the kinetics of chloramphenicol binding to 70S ribosomes containing the fluorescent derivative. The fluorescence change followed first-order kinetics, suggesting that chloramphenicol induces a conformational change in the 70S particle. This could explain both its effect on erythromycin binding and on the fluorescence of bound analogue. Less detailed results with the 50S particle indicate a qualitively similar picture of erythromycin-chloramphenicol interactions.
Jale3D-platform-independent IC/MEMS layout edition tool (2002)

This paper describes the Jale3D, a tool developed as part of the Cave Framework. The main features of the tool are the edition and the visualization of the layout information from both integrated circuits (ICs) and micro-electromechanical systems (MEMS). The use of the Virtual Reality Modeling Language as a way to create 3D models of integrated circuits and MEMS is also presented.
Molecular Characterization of a Putative Sodium/Iodide Symporter in the South African Clawed Frog,<i>Xenopus laevis</i> (2003)

QQ 1< $FDG 6FL 1HZ <RUN $FDGHP\ RI
ActaDV Soon Celebrates 100-year Anniversary (2018)

Abstract is missing (Editorial)
New Metabolizable Immunologic Adjuvant for Human Use. I. Development and Animal Immune Response (1964)

A new immunologic adjuvant, adjuvant 65, is described and the results of extensive tests of polyvalent influenza virus vaccine in the adjuvant are presented. The vaccine consists of a water-in-oil emulsion in which the adjuvant portion consists of peanut oil, mannide monooleate and aluminum monostearate. The adjuvant effect measured in terms of hemagglutination-inhibition antibody responses 28 days after vaccination in mice or guinea pigs is roughly equal to that obtained with Freund's incomplete mineral oil adjuvant. Adjuvant 65 influenza vaccine showed striking enhancement and long-term persistence of antibody in guinea pigs, rabbits and monkeys compared with the corresponding aqueous vaccines. The findings in histomorphologic-pathologic studies in animals and the clinical and serologic results obtained in large-scale studies in man are presented elsewhere. Adjuvant 65 shows promise of meeting the present urgent need for a safe and effective adjuvant for enhancing immunologic responses to viral and other vaccines and possibly also for treating allergic disease.
Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS (2015)

We report on a new, sensitive, and fast LC-MS/MS method for the simultaneous determination of 25 key sphingolipid components in human plasma, including phosphorylated sphinganine and sphingosine, in a single 9-min run. This method enables an effective and high-throughput coverage of the metabolic changes involving the sphingolipidome during physiological or pathological states. The method is based on liquid-liquid extraction followed by reversed-phase LC-MS/MS. Exogenous odd-chain lipids are used as cost-effective but reliable internal standards. The method was fully validated in surrogate matrix and naive human plasma following FDA guidelines. Sample stability and dilution integrity were also tested and verified.
Alcohol Redirects CCK‐Mediated Apical Exocytosis to the Acinar Basolateral Membrane in Alcoholic Pancreatitis (2007)

The molecular mechanism of clinical alcohol-induced pancreatitis remains vague. We had reported that experimental high-dose cholecystokinin (CCK)-induced pancreatitis is in part because of excessive aberrant basolateral exocytosis. High-dose CCK caused Munc18c on basolateral plasma membrane (BPM) to dissociate from syntaxin (Syn)-4, activating Syn-4 to complex with plasma membrane (PM)-SNAP-23 and granule-VAMP to mediate basolateral exocytosis. We now hypothesize that alcohol could render the acinar cell BPM conducive to exocytosis by a similar mechanism. Weakly stimulating postprandial doses of alcohol (20-50 mM) inhibited postprandial low-dose CCK-stimulated secretion by blocking physiologic apical exocytosis and redirecting exocytosis to less-efficient basal PM (visualized by FM1-43 fluorescence imaging) and lateral PM sites (electron microscopy). Alcohol or low-dose CCK had no effect on PM-Munc18c, but alcohol preincubation enabled low-dose CCK to displace Munc18c from BPM, leading to SNARE complex assembly in the BPM. Similarly, alcohol diet-fed rats did not exhibit morphologic defects in the pancreas nor affected PM-Munc18c behavior, but subsequent intraperitoneal injections of low-dose CCK analog cerulein caused Munc18c displacement from BPM and cytosolic degradation, which contributed to pancreatitis. We conclude that alcohol induces BPM-Munc18c to become receptive to postprandial CCK-induced displacement into the cytosol, a process which facilitates SNARE complex assembly that in turn activates restricted BPM sites to become available for aberrant exocytosis into the interstitial space, where zymogen activation would take place and cause pancreatitis.
Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research (2018)

Birch-bark triterpenoids and their semi-synthetic derivatives possess a wide range of biological activities including cytotoxic effects on various tumor cell lines. However, due to the low solubility and bioavailability, their medicinal applications are rather limited. The use of various nanotechnology-based drug delivery systems is a rapidly developing approach to the solubilization of insufficiently bioavailable pharmaceuticals. Herein, the drug delivery systems deemed to be applicable for birch-bark triterpenoid structures are reviewed. The aforementioned disadvantages of birch-bark triterpenoids and their semi-synthetic derivatives can be overcome through their incorporation into organic nanoparticles, which include various dendrimeric systems, as well as embedding the active compounds into polymer matrices or complexation with carbohydrate nanoparticles without covalent bonding. Some of the known triterpenoid delivery systems consist of nanoparticles featuring inorganic cores covered with carbohydrates or other polymers. Methods for delivering the title compounds through encapsulation and emulsification into lipophilic media are also suitable. Besides, the birch-bark triterpenoids can form self-assembling systems with increased bio-availability. Even more, the self-assembling systems are used as carriers for delivering other chemotherapeutic agents. Another advantage besides increased bioavailability and anticancer activity is the reduced overall systemic toxicity in most of the cases, when triterpenoids are delivered with any of the carriers.
Baroreflex sensitivity and cardiovascular mortality in patients with mild to moderate heart failure. (1995)

Low vagal tone is correlated with a poor prognosis in patients with heart failure. Sympathetic tone measured as plasma noradrenaline concentration also contributed to survival. An additional contribution of vagal tone to survival could not be shown when sympathetic tone was considered simultaneously. This may be due to the inverse relation of sympathetic and parasympathetic tone and to the insensitivity of the multiple regression method to identify additional risk factors in small numbers of patients.
Regulation of Phosphorylase b by AMP (1980)

The enthalpies of binding of AMP to phosphorylase b have been measured as a function of enzyme concentration in glycylglycine buffer, pH 6.9. The results show how a conformational transition, which takes place in the concentration range of 1.7 to 2.5 mg/ml of phosphorylase b, affects the enthalpies of the two binding sites per monomer for the allosteric activator AMP. The enthalpies of the AMP interaction with its higher and lower affinity binding sites are -220 and -640 kJ (mol monomer)-1 at an enzyme concentration of 1 mg/ml, and -120 and -360 kJ (mol monomer)-1 at 2.7 mg/ml. The conformational transition of phosphorylase b alters the reactivity of the slow -SH groups of the enzyme with 5,5'-dithiobis(2-nitrobenzoic acid), suggesting that the environment of these groups are affected by the process. On the other hand, kinetic data show that the saturation of both classes of AMP binding sites affects the catalytic behavior and that their specific effects on the catalytic process are altered by the enzymatic transition dependent on the enzyme concentration. Thus, a strong inhibition is associated with the saturation of the weaker affinity AMP binding sites at 3 mg/ml while the saturation of these weaker affinity binding sites at 1 mg/ml produces an important activation of the enzyme.
Abstract 574: High-Density Lipoproteins Suppress Amyloid Beta Induced Human Brain Microvascular Endothelial Cell Activation (2017)

Introduction: Epidemiological studies suggest a link between plasma high-density lipoprotein (HDL) cholesterol levels and Alzheimer’s disease (AD) risk through mechanisms that are not understood. We hypothesize that HDL protects against AD through actions at the blood-brain-barrier. HDL has vasoprotective functions in large peripheral arteries, however, it is unknown if these functions extend to cerebral vessels to reduce the contribution of cerebrovascular dysfunction in AD pathogenesis. We investigated in vitro interactions between HDL and amyloid beta (Aβ), the toxic peptide known to accumulate in AD, in peripheral and brain-derived endothelial cells (EC). Methods: HDL was isolated by density gradient ultracentrifugation and added to human umbilical vein endothelial cells (HUVEC) or human cerebral microvascular endothelial cells (hCMEC/D3). Cell activation was measured by counting adhered labelled peripheral blood mononuclear cells (PBMC) after stimulation with tumour necrosis factor α (TNFα) or Aβ. Aβ binding and uptake into cells was measured using ELISA and immunofluorescence. All experiments included at least 4 independent replicates. Results: We demonstrate that HDL attenuates Aβ-induced EC activation independent of nitric oxide production, miR-233 and changes in adhesion molecule expression. Rather, HDL acts through scavenger receptor BI to block Aβ uptake into ECs and, in vitro , can maintain Aβ in a soluble state. We validated our results using three dimensional engineered vessels composed of primary human endothelial and smooth muscle cells. Following Aβ addition to the abluminal (brain) side, we demonstrated that HDL circulated within the lumen attenuates EC activation, again independent of intracellular adhesion molecule changes. Conclusions: We show that the anti-inflammatory activities of HDL extend to cerebrovascular endothelial cells and work to suppress Aβ-induced activation through a novel mechanism involving the inhibition of Aβ binding and uptake into cells through SR-BI. The protective role for HDL against Aβ may explain the epidemiological evidence supporting a protective effect of high plasma HDL cholesterol levels against dementia.
SeqVISTA: a graphical tool for sequence feature visualization and comparison (2003)

SeqVISTA allows insights to be gained by viewing the totality of sequence annotations and predictions, which may be more revealing than the sum of their parts. SeqVISTA runs on any operating system with a Java 1.4 virtual machine. It is freely available to academic users at http://zlab.bu.edu/SeqVISTA.