gebhart/patrepeval huggingface dataset:
Development of an Intravenous Bile Acid Tolerance Test (1975)

To develop an intravenous bile acid tolerance test that might be useful for detecting impaired liver function or liver injury, the plasma disappearance of intravenously injected cholyglycine was characterized in healthy man by a radiommunoassay, specific for conjugates of cholic acid, on serial samples of venous blood. Cholylglycine disappearance was rapid (mean half-life plus or minus S.E. equals 2.6 plus or minus 0.1 minutes) and of first-order kinetics; the rate of disappearance was independent of dose between 2 and 15 mumoles per kilogram of body weight. A dose of 5 mumoles per kilogram was selected as an optimal dose, and its clearance was defined in 45 healthy subjects. After intravenous injection of this dose, conjugates of cholic acid increased 10-fold, but in all subjects the concentration of these bile acids had returned to 1 muM (the upper limit of normal, fasting state) by 10 minutes. No side effects were observed.
Synthesis of Thermally Stable χ‐Alumina by Thermal Decomposition of Aluminum Isopropoxide in Toluene (2004)

Thermal decomposition of aluminum isopropoxide in toluene at 315°C resulted in χ‐alumina that had high thermal stability, whereas the reaction at lower temperatures resulted in formation of an amorphous product. The χ‐alumina thus obtained directly transformed to α‐alumina at ∼1150°C, bypassing the other transition alumina phases, whereas the amorphous product transformed to γ‐alumina and then to θ‐alumina before final transformation to α‐alumina. When the χ‐alumina, solvothermally synthesized at 315°C, was recovered by the removal of the solvent at the reaction temperature, thermal stability of the product was improved further. This procedure is convenient because it avoids bothersome work‐up processes that yield large‐surface‐area and large‐pore‐volume alumina.
Inhibitors of PLA2 and NO synthase cooperate in producing amnesia of a spatial task (1995)

Both nitric oxide and arachidonic acid have been suggested to play a role as a retrograde messenger in synaptic plastic changes which underlie memory formation. However, inhibitors of nitric oxide (NO) synthesis or of arachidonic acid release have produced contradictory results. We suggest a model which involves simultaneous release of both messenger types which can compensate for the loss of one type. To test this theory, rats were injected either with a drug that inhibits release of arachidonic acid, or a drug that inhibits synthesis of NO, or with both drugs. Acquisition of a water maze task was not different between groups. In the test sessions, however, animals injected with both drugs showed marked amnesic symptoms, while the groups injected with a low dose of nordihydroguaiaretic acid (NDGA) or with nitro-L-arginine (L-NARG) showed a trend towards amnesia. The effect of both drugs appears to be additive. The results support the proposed theory.
Structure investigation of dimethyl-aluminium, -gallium and -indium O,O′-chelate complexes in solution and the solid state. Molecular structure of five-co-ordinated [Me2M(μ-OC6H4CO2Me-2)]2 adducts (1997)

The reaction of trimethyl-aluminium, -gallium and -indium with an equimolar amount of methyl salicylate, 2-(HO)C6H4CO2Me (Hmesal), gives [Me2M(mesal)]n chelate complexes in high yield (where n = 1 or 2, M = Al 1 or Ga 2; n = 2, M = In 3). The resulting compounds have been characterised in solution by NMR and IR spectroscopy as well as by cryoscopic molecular weight determinations in benzene; their molecular structures in the solid state were determined by single-crystal X-ray diffraction techniques. All three compounds are dimeric in the solid state, with five-co-ordinated metal centres. The deformation of the metal centre co-ordination sphere is discussed. In solution compounds 1 and 2 are monomeric, four-co-ordinated chelate complexes while 3 retains its dimeric structure. On the basis of the structural observation resulting from this study and with respect to related compounds the following sequence of the Group 13 metal centre Lewis acidity, in four-co-ordinated diorganometallic O,O′-chelate complexes is proposed: In Al > Ga.
Experiences with Regional Chemotherapy (1962)

During the past 4 years, regional chemotherapy has been employed in the M. D. Anderson Hospital primarily as a medium of research in cancer, and secondarily for therapeutic purposes. At present, the 2 methods of administration consist of (1) perfusion with the use of the heart-lung machine, as suggested by Klopp<sup>5,6</sup>and developed by Creech,<sup>2,3</sup>and (2) continuous intra-arterial infusion, based upon the original work of Klopp<sup>5,6</sup>and Bierman<sup>1</sup>and their co-workers, and developed by Sullivan.<sup>14</sup>As of Dec. 1, 1961, 265 perfusions had been performed for 209 patients, and 54 infusions for 48 patients. In the conviction that major "breakthroughs" in cancer research can best be achieved by cooperation between clinicians and investigators in the basic sciences, our approach has been a multidisciplinal one, in which surgeons, radiotherapists, pathologists, biochemists, biologists, and physicists have worked together. Herein will be presented some of the investigative
Properties of antitumor activity of vinorelbine tartrate, a new vinca alkaloid antitumor agent. (2000)

酒石酸ビノレルビン (VNR) は Potier らによって半合成された新規のビンカアルカロイド誘導体である. VNRは他のビンカアルカロイドと比べ同等以上の抗腫瘍効果を示し,神経毒性が弱いという特徴を持つ.ヌードマウス移植ヒト腫瘍モデルにおいて, VNR はヒト腫瘍11株(非小細胞肺癌:4株,乳癌:3株,結腸癌:2株,胃癌:2株)のうち,非小細胞肺癌4株,乳癌2株および胃癌2株,計8株に対して有意な増殖抑制効果を示した.特にVNRは非小細胞肺癌の LC-6 および乳癌 MX-1 に対して腫瘍の退縮を伴う抗腫瘍効果を示した. VNRの非小細胞肺癌に対する抗腫瘍効果は,非小細胞肺癌の適応を持つビンカアルカロイド系抗癌薬のビンデシン (VDS) と比べ優れていた.また, VNR とシスプラチン (CDDP) との併用療法は,従来の標準療法である VDS と CDDP との併用に比べ優れていた. VNR の低神経毒性は, VNR の有糸分裂期の紡錘糸微小管に対する作用よりも神経軸索の微小管に対する作用が弱いことに起因すると考えられた.神経軸索の微小管が紡錘糸微小管より低感受性であることについては,微小管構成タンパクの一つである TAU タンパク異性体の関与が推察された.臨床において, VNR は非小細胞肺癌に対して従来の VDS に比べ有意に高い奏効率を示し, CDDP と併用すると VDS より奏効率および生存期間において有意に優れていた.乳癌に対しては,1st line だけでなく2nd lineとしても優れた奏効率が報告され,更にアントラサイクリン,5-FU,Taxol 等との併用で,優れた腫瘍効果が報告されている.本邦においては,現在,乳癌を対象とした治験が進行中である.
Syntheses and structures of [HB(pz)3](CO)2(CS)W-Au(PR3). First examples of a semibridging thiocarbonyl ligand (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses and structures of [HB(pz)3](CO)2(CS)W-Au(PR3). First examples of a semibridging thiocarbonyl ligandHeesook P. Kim, Sangsoo. Kim, Robert A. Jacobson, and Robert J. AngeliciCite this: J. Am. Chem. Soc. 1986, 108, 17, 5154–5158Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ja00277a020https://doi.org/10.1021/ja00277a020research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Treatment of in-stent restenosis in a gastroepiploic artery coronary bypass graft with brachytherapy. (2003)

The pedicled right gastroepiploic artery is used as an arterial conduit in a select group of patients undergoing coronary artery bypass grafting with favorable patency and survival rates. Myocardial ischemia can occur, especially secondary to distal anastomotic stenosis. Percutaneous coronary interventions have been successful in treating these stenoses, precluding further challenging and higher risk operations. The restenosis rate of such interventions is unknown. We describe a case of distal right gastroepiploic graft anastomotic stenosis that was initially treated with percutaneous angioplasty, but later required stenting for restenosis. Subsequent in-stent restenosis was successfully treated with angioplasty and brachytherapy via the left axillary approach.
Sporadic Creutzfeldt-Jakob Disease Mimicking Variant Creutzfeldt-Jakob Disease (2003)

This case cautions against relying solely on T2- and diffusion-weighted pulvinar hyperintensity and clinical features to differentiate between vCJD and sCJD, and further supports established diagnostic criteria for vCJD.
Functional analysis of the <i>Helicobacter pylori</i> principal sigma subunit of RNA polymerase reveals that the spacer region is important for efficient transcription (1998)

We have cloned the rpoD gene encoding the principal sigma (sigma) factor of Helicobacter pylori. The deduced amino acid sequence reveals a predicted polypeptide of 676 residues that has amino acid homology with the principal sigma factors of a number of divergent prokaryotes. We have designated this factor sigma80. Amino acid sequence analysis suggests that region 1.1 is missing in sigma80 and that a region with homology to a regulatory protein from Bacillus subtilis phage SPO1 is present. Genetic studies have indicated that sigma80 is not compatible with the transcriptional machinery of Escherichia coli. However, in vitro sigma80 could be assembled into the E. coli RNA polymerase and could bind to E. coli and H. pylori promoters, suggesting that the sigma80-containing RNA polymerase has the same stoichiometry as the native complex. By exchanging protein domains between E. coli and H. pylori sigma factors, we demonstrate that the sigma80 domain inhibiting transcription from E. coli promoters is confined within the non-conserved spacer region, implying that the spacer region of prokaryotic primary sigma factors plays an important role in the process of transcription. Consistent with its restricted niche and with the availability of a very restricted number of transcriptional regulators, H. pylori may have evolved a spacer region of the sigma factor to modulate total transcription and to quickly respond to microenvironmental changes.
2‐Acetyl‐cyclanone und Cyclandione‐(1.3), ein Vergleich (1968)

Abstract Die Eigenschaften der 2‐Acetyl‐cyclanone ( 1 , n = 6‐13) und der Cyclandione‐(1.3) ( 2 , n + 2  n′ = 8 ‐ 15) werden beschrieben und miteinander verglichen. Folgende Meßgrößen werden diskutiert: NMR‐, UV‐ und IR‐Spektren, Enol‐Gehalt, IR‐ und UV‐Spektren der Kupfer‐Enolchelate und NMR‐ und UV‐Spektren der Pyrazol‐Derivate.
DEVELOPMENT OF FERRITIC STEELS FOR HIGH TEMPERATURE SODIUM SERVICE. PART I. 2.25 Cr-1 Mo-0.4 Cb-0.4 Ti EXPERIMENTAL ALLOY (1960)

The commercially available ferritic chromium-molybdenum steels have several advantages over austenitic stainless steels. However, they have lower high-temperature strength, tend to decarburize in sodium systems containing austenitic steels, and require post-weld heat treatments. The purpose of this study is to develop a ferritic steel which has strength at 1100 deg F equal to Type 304 stainless steel, resists decarburization in sodium systems, and does not require a complex post-weld heat treatment. In the alloy development program at Atomics International, niobium and titanium are added to conventional chromiummolybdenum high temperature steels. A 2.25% Cr-1% Mo0.4% Nb-0.4% Ti analysis was produced and evaluated. The results on this preliminary heat-of- steel show that the short time tensile, creep, and stress rupture properties are equivalent to Type 304 SS at temperatures at least up to 1100 deg F. In a sodium system this steel was found to be neutral to Type 304 SS with respect to carbon transfer. (auth)
Exciton–surface plasmon coupling: An experimental investigation (1982)

Langmuir–Blodgett monolayer assemblies, which contained dye molecules, have been deposited on silver films. Exciton–surface plasmon interactions have been studied with attenuated total reflection (ATR) spectroscopy. Reflectivity and dispersion curves for plasmon surface polaritons (PSP’s) at the metal interface are reported for both angular and wavelength scans. In agreement with theory dispersion curves from angle scans exhibit a double ‘‘back bending’’ at the transverse exciton frequency ωT (due to PSP interaction with the in plane component of the dye transition dipole moment) and at the longitudinal frequency ωL (due to PSP interaction with a perpendicular component). Correspondingly, dispersion curves from wavelength scans break into separate branches at these frequencies.
Preparation and characterization of Tl sub 2 Ba sub 2 CaCu sub 2 O sub 8 films on (100) LaAlO sub 3 (1991)

A two-step process for the fabrication of 0.12-1.20 {mu}m-thick Tl{sub 2}Ba{sub 2}CaCu{sub 2}O{sub 8} films on (100) LaAlO{sub 3} has been developed. The process involves the deposition of a BaCaCuO precursor film at low temperature by rf magnetron sputtering, followed by annealing in the presence of Tl{sub 2}O vapor to convert the precursor film into Tl{sub 2}Ba{sub 2}CaCu{sub 2}O{sub 8}. Over a distance of 4 cm, film composition was Tl:Ba:Ca:Cu = 2.05 {plus minus} 0.09:2.05 {plus minus} 0.06:1.0 {plus minus} 0.3:1.94 {plus minus} 0.6 and thickness was uniform to within 6%. The films contain only trace quantities of secondary phases and are epitaxially oriented, with the c-axis of Tl{sub 2}Ba{sub 2}CaCu{sub 2}O{sub 8} perpendicular to the surface and the two a-axes aligned with the pseudo-cubic a-axes of the underlying LaAlO{sub 3} substrate. Films had a T{sub c} for zero dc resistivity of 106.5 {plus minus} 0.5 K,a transport critical current density for continuous current of 2.9 {times} 10{sup 6} A-cm{sup {minus}2} at 77 K, and a sharp ({lt}0.3{degrees} C) ac inductance transition with an onset temperature of 105 {plus minus} 2 K. Surface resistance at 20 GHz less than 2 m{Omega}, about 10X lower than Cu, was routinely achieved formore » temperatures below 90 K and, for the best films, at temperatures up to 100 K. Surface resistance at about 10 GHz on one film was 0.067 m{Omega} at 4.2 K, 0.36 m{Omega} at 77 K, and 0.74 m{Omega} at 90 K. Films have been reproducibly fabricated on substrates up to 2.54 cm square.« less
A pipelined parallel processor to implement MD4 message digest algorithm on Xilinx FPGA (2002)

The paper presents a pipelined parallel processor architecture design to implement the MD4 message digest algorithm which computes the message digest or the fingerprint of 128 bit fixed length, for any arbitrary length of input message. The processor implements the arithmetic, logic and circular shift operations by a pipelined parallel process. The architecture is designed to suit the design flexibility of the Xilinx Field Programmable Gate Arrays (FPGAs) The processor reads the message from an external RAM, 16-bit at a time and internal operations are performed with 32-bit data. The major advantage of the design is increased speed of computation and minimum hardware. The processor computes the digest with a speed approximately three times faster than the software version implemented in DSP processors.
Design of low noise wind turbine blades using Betz and Joukowski concepts (2014)

This paper presents the aerodynamic design of low noise wind turbine blades using Betz and Joukowski concepts. The aerodynamic model is based on Blade Element Momentum theory whereas the aeroacoustic prediction model is based on the BPM model. The investigation is started with a 3MW baseline/reference turbine rotor with a diameter of 80 m. To reduce the noise emission from the baseline rotor, the rotor is reconstructed with the low noise CQU-DTU-LN1 series of airfoils which has been tested in the acoustic wind tunnel located at Virginia Tech. Finally, 3MW low noise turbine rotors are designed using the concepts of Betz and Joukowski, and the CQU-DTU-LN1 series of airfoils. Performance analysis shows that the newly designed turbine rotors can achieve an overall noise reduction of 6 dB and 1.5 dB(A) with a similar power output as compared to the reference rotor.
Temperature-sensitive tumorigenicity of cells transformed by a mutant of Moloney sarcoma virus. (1980)

Normal rat kidney cells were nonproductively infected either with CP27, a mutant of Moloney sarcoma virus that is temperature-sensitive for maintenance of transformation, or with the parental wild-type virus. The nonproducer cells were inoculated into the tails of athymic nude mice that were subsequently incubated at 28 or 36 degrees C. CP27-infected cells induced tumors only at 28 degrees C, whereas cells infected with wild-type Moloney sarcoma virus were tumorigenic at both temperatures. Tumors induced at 28 degrees C by wild-type virus-infected cells grew faster after shift of the mice to 36 degrees C. In contrast, tumors induced by CP27-infected cells regressed upon shift to 36 degrees C, indicating that continuous expression of viral functions is required for persistence and growth of the tumors. After regression, secondary tumor growth was observed late after upshift of temperature-sensitive tumors. Cells recovered from these late-appearing tumors were tumorigenic at the nonpermissive temperature, and tumors induced by these cells did not regress after upshift. Virus rescued from these recovered cells retained the temperature-sensitivity for focus formation, indicating that the occurrence of the phenotypically wild-type cells was due to host cell modifications rather than to reversion of the CP27 genome.
Towards automated crystallographic structure refinement with <i>phenix.refine</i> (2012)

phenix.refine is a program within the PHENIX package that supports crystallographic structure refinement against experimental data with a wide range of upper resolution limits using a large repertoire of model parameterizations. It has several automation features and is also highly flexible. Several hundred parameters enable extensive customizations for complex use cases. Multiple user-defined refinement strategies can be applied to specific parts of the model in a single refinement run. An intuitive graphical user interface is available to guide novice users and to assist advanced users in managing refinement projects. X-ray or neutron diffraction data can be used separately or jointly in refinement. phenix.refine is tightly integrated into the PHENIX suite, where it serves as a critical component in automated model building, final structure refinement, structure validation and deposition to the wwPDB. This paper presents an overview of the major phenix.refine features, with extensive literature references for readers interested in more detailed discussions of the methods.
INHIBITION OF ETHYLENE VIA DIFFERENT WAYS AFFECTS LOX AND ADH ACTIVITIES, AND RELATED VOLATILES COMPOUNDS IN PEACH (CV. ´ROYAL GEM´) (2005)

Peach aroma depletion is the main reason for the reduced consume of peaches in the market. The reason of this low aroma development is the early harvest and the use of low temperature. In previous papers we showed a relationship of volatiles development with ethylene production of peaches. Here we studied the influence of different treatments to inhibit ethylene production on ethylene production, commercial quality characteristics, and volatiles in relationships to enzymatic activities. Peaches (cv. 'Royal Gem') were picked at early ripening stage (10-11% SSC and 60-68 N firmness) in July and successively separated to be treated with N 2 (100%) for 44 h at 20°C + in air at 20°C and 80% RH until day 9, or 1 ppm 1-MCP for 20 h at 20°C + in air at 20°C until day 9, or at 3° in air for 7 d + at 20°C for 2 d, or for 9 d in air at 20°C (control). Ethylene was reduced greatly by nitrogen and low temperature. 1-MCP had intermediate values between these two treatments and the control. This ethylene response affected firmness and deformation of peaches but not the SSC (soluble solids content). Even volatiles, mainly esters, were affected by ethylene level. Control fruits showed the highest volatiles content (peak area) after 2 days in parallel with the rise of ethylene for the climacteric peak. 1-MCP treated fruits showed the highest volatiles value after 6 days when the ethylene production reached a value of 4 μL kg -1 h -1 slightly lower than the level reached by the control 4 days before. Nitrogen and low temperature-treated fruits showed very low ethylene production even after the shift to normal atmosphere (nitrogen treatment); consequently the total volatiles were lower. Nitrogen treated peaches developed an aroma with sweet nuance due to the high content of ethanol and acetate esters. Alcohol dehydrogenase (ADH) activity was related to alcohol formation. Lypoxygenase (LOX) activity was high in nitrogen-treated fruits but C6 compounds were partially related to the enzyme activity. Low temperature treated peaches increased the lactones production when transferred to higher temperatures but the esters content remained lower. Nitrogen can represent a good postharvest treatment for the peach distribution.
Identification of aneuploidy in recurrent clear cell hidradenoma by DMA image cytometry (ICM‐DNA) (1997)

Since malignant clear cell hidradenoma (CCH) is often characterized by only slight and sometimes by absent nuclear anaplasia, even in metastases, definitive differentiation from its benign counterpart by light microscopy may be very difficult. Herein, we report the case of a 72-year-old woman suffering from a CCH on the back, which showed local recurrence following incomplete excision. By light microscopy no unequivocal signs of malignancy were found either in the primary or the recurrent tumor. However, unusual deep extension to the subcutis with some architectural disorder was seen in the latter. Identification of prospective malignancy in such cases of borderline histopathological features is one of the main indications for diagnostic DNA image cytometry (ICM-DNA). Application of this method to enzymatic cell separation specimens of the recurrence detected marked DNA-aneuploidy with a stemline ploidy of 2.60 c and single events up to 6.7 c, whereas a nearly exact diploid DNA-stemline was found in the primary. We suppose from our results that a prospective malignant CCH with aneuploid DNA-stemline has developed out of its DNA-diploid counterpart. The need for total surgical removal of apparently benign clear cell hidradenomas is further stressed by this observation. Criteria for the diagnosis of malignancy in CCH are reviewed.