gebhart/patrepeval huggingface dataset:
On choice of turbulence model for prediction of flows over river bed forms (1997)

A fully developed turbulent open channel flow with a bed consisting of a space-periodic array of triangular elements has been numerically simulated. The solution procedure is based on the pressure-correction finite volume method with a collocated variable arrangement. Decoupling of the equations, inherent to the collocated variable arrangement, is avoided by using well-known Rhie and Chow interpolation technique. Reynolds stresses are approcimated using k-∊ and a full transport Reynolds-stress models of turbulence. Wall boundary condition takes into account wall roughness while the free surface is treated as a symmetry plane for all variables apart from the dissipation of turbulence kinetic energy. Comparisons between prediction and the measurements indicate that the k-∊ model of turbulence is capable of predicting the main features of the flow to the acceptable level of accuracy.
Mechanism design (2012)

Algorithmic mechanism design is concerned with designing algorithms for settings where inputs are controlled by selfish agents, and the center needs to motivate the agents to report their true values. In this paper, we study scenarios where the center may be able to verify whether the agents report their preferences (types) truthfully. We first consider the standard model of mechanism design with partial verification, where the set of types that an agent can report is a function of his true type. We explore inherent limitations of this model; in particular, we show that the famous Gibbard--Satterthwaite impossibility result holds even if a manipulator can only lie by swapping two adjacent alternatives in his vote. Motivated by these negative results, we then introduce a richer model of verification, which we term mechanism design with probabilistic verification. In our model, an agent may report any type, but will be caught with some probability that may depend on his true type, the reported type, or both; if an agent is caught lying, he will not get his payment and may be fined. We characterize the class of social choice functions that can be truthfully implemented in this model. We then proceed to study the complexity of finding an optimal individually rational implementation, i.e., one that minimizes the center's expected payment while guaranteeing non-negative utility to the agent, both for truthful and for non-truthful implementation. Our hardness result for non-truthful implementation answers an open question recently posed by Auletta et al. [2011].
Fractional Factorial Experiments (2003)

Complete factorial experiments cannot always be conducted because of economic, time, or other constraints. Fractional factorial experiments are widely used in such circumstances. In this chapter fractional factorial experiments for two-level and three-level factors are detailed. A problem solving section appears at the end of the chapter. The appendix of this chapter discuss fractional factorial design generators.
Cardiac autonomic regulation after lung exposure to carbon nanotubes (2009)

The ultrafine (UF) component of airborne pollution may impair cardiovascular autonomic control, a high-risk condition for cardiovascular adverse events. Since engineered nanoparticles, such as single-walled carbon nanotubes (SWCNTs) share physicochemical properties with UF, they might have similar adverse effects. Aim of the study was to evaluate arterial baroreflex function (BRF) at baseline, 24 h after the first instillation, immediately before the second one, and 2 weeks later, in adult Wystar-Kyoto conscious rats undergoing two intratracheal instillations of SWCNT (eight rats) or phosphate buffer saline (PBS) (five rats) at 2-week interval. During each session, 30-min continuous recording of arterial pressure and pulse interval was performed by a telemetered catheter implanted in the abdominal aorta of the rats. BRF was studied by the sequence technique. SWCNTs dispersed in PBS (1 mg/ml) were administered immediately after sonication (1 microg/g body weight). A significant decrease in the number of baroreflex sequences (from 498 +/- 27.1 at baseline to 287 +/- 40.2 at the recording performed after 4 weeks; P < 0.05) was observed in SWCNT-instilled rats, whereas no significant change was detected in controls. These data suggest that SWCNTs may alter the BRF, thus affecting the autonomic cardiovascular control regulation.
Differentiation of voltage‐gated potassium current and modulation of excitability in cultured amphibian spinal neurones. (1986)

Gigaohm-seal whole-cell voltage-clamp techniques were used to study the development of ionic currents in the membrane of embryonic amphibian (Ambystoma) spinal neurones during in vitro differentiation. Dissociated neural plate cells, some of which are neuronal precursor cells, were placed into culture. Cells became excitable at the time of neurite outgrowth, 2-3 days later, and over the next 2-10 days the duration of the action potential shortened from about 100 ms to about 1 ms. Voltage-clamp recordings demonstrated that at the time of appearance of neurites, activatable Na, Ca and voltage-gated K channels were present in the membrane (Ca-dependent K channels were not studied). Over succeeding days in culture, records of total membrane current indicated that the amplitudes of peak inward and steady-state outward currents both increased. As a result of these increases, the pattern of total membrane current came to be increasingly dominated by outward currents. With inward Na and Ca currents blocked, a voltage-gated K current (IK(V] could be studied in isolation. The reversal potential of this current varied in good agreement with the equilibrium potential for K ions predicted by the Nernst relation. The wave form of IK(V) activation was sigmoidal. Activation was more rapid at more positive voltages (relative to the usual holding potential of -70 mV), and deactivation was more rapid at more negative voltages. The amplitude of IK(V) increased during neural development, while cell size remained approximately constant. Increases in rates of activation and deactivation were observed in parallel with the increase in current density. When measured at 0 mV, cells studied on day 4 of culture or earlier showed steady-state chord conductances (gK(V] of less than 20 nS, and one-half activation times (t1/2) of 2 X 5-10 ms. Older cells showed gK(V)s of 10-80 nS, and t1/2s of 0 X 8-2 X 5 ms. As Na, and to a lesser extent Ca, current amplitudes were also increasing during differentiation, these observations concerning IK(V) suggested that its amplitude and kinetic changes might in part be responsible for the observed decrease in action potential duration during development. This hypothesis was tested by modelling Na, Ca and voltage-gated K currents and testing the effects of changes in amplitude and kinetics of IK(V) on the duration and ionic dependence of reconstructed action potentials. The results obtained using this model suggested that the increase in IK(V) amplitude and activation rate was sufficient to change action potential duration and apparent ionic sensitivity.
On Conformally Covariant Spinor Field Equations (1972)

Conformally covariant equations for free spinor fields are determined uniquely by carrying out a descent to Minkowski space from the most general first-order rotationally covariant spinor equations in a six-dimensional flat space. It is found that the introduction of the concept of the "conformally invariant mass" is not possible for spinor fields even if the fields are defined not only on the null hyperquadric but over the entire manifold of coordinates in six-dimensional space.
Liability Claims and Costs Before and After Implementation of a Medical Error Disclosure Program (2010)

Blue Cross Blue Shield of Michigan Foundation.
SU‐E‐T‐146: Reference Dosimetry for Protons and Light‐Ion Beams Based on Graphite Calorimetry (2012)

The application of graphite calorimetry to proton, alpha and carbon ion beams has been demonstrated successfully. Other experimental campaigns will be held in 2012. This work is supported by the BioWin program of the Wallon Government.
Design of illumination system in ring field capsule endoscope (2011)

This paper is researching about the illumination system in ring field capsule endoscope. It is difficult to obtain the uniform illumination on the observed object because the light intensity of LED will be changed along its angular displacement and same as luminous intensity distribution curve. So we use the optical design software which is Advanced Systems Analysis Program (ASAP) to build a photometric model for the optimal design of LED illumination system in ring field capsule endoscope. In this paper, the optimal design of illumination uniformity in the ring field capsule endoscope is from origin 0.128 up to optimum 0.603 and it would advance the image quality of ring field capsule endoscope greatly.
Reinforcement of Natural Latex Rubber by Carbon Black and Ionizing Radiation (1962)

Abstract The study of the reinforcement of rubber by carbon black has made it possible to establish the radical nature of the interaction, thus explaining why, in the latex phase and in the absence of sources of radicals, the reinforcing effect of carbon black does not exist and why it has been possible up to the present to obtain it only by mastication of the solid rubber in the presence of black. Irradiation, an excellent source of radicals, should in latex systems lead to a reinforcement of rubber by black. The experiments carried out appear to prove this. Irradiation of the latex and the black in aqueous dispersion, followed by a mixture of the two constituents which is then poured out on a plate, dried and subjected to moderate thermal treatment, makes it possible to obtain mechanical properties which are definitely superior to those of films prepared without irradiation and of films vulcanized with sulfur.
Nanomechanical Traceable Metrology of Vertically Aligned Silicon and Germanium Nanowires by Nanoindentation (2017)

Silicon and germanium pillar structures (i.e., micro- and nanowires) were fabricated by a top-down approach including nanoimprint lithography and cryogenic dry etching. Various etching parameters were tested to ensure a reliable fabrication process. The impression of nanomechanical properties of such 3-D structures were extracted experimentally by nanoindentation showing promising and comparative results to utilize such nanostructures as small force artefacts.
Multichannel Mueller matrix analysis of the evolution of the microscopic roughness and texture during ZnO:Al chemical etching (2005)

Transparent conducting oxides (TCOs) are used in thin film silicon (Si:H) photovoltaics (PV) technology as top electrical contacts and as the components of back-reflecting structures. TCOs are often prepared with macroscopically rough interfaces and/or surfaces (i.e., with "texture") in order to scatter light and thereby enhance optical path lengths in the active layers of the device. Optical analysis of textured TCOs is a considerable challenge, due to the existence of surface roughness and non-uniformity over more than six orders of magnitude in the lateral scale L, from tenths of nanometers to hundreds of microns or more. In this research, we have developed the optical technique of multichannel Mueller matrix ellipsometry to extract the optical properties (/spl epsi//sub 1/, /spl epsi//sub 2/) of textured TCO films as well as the time evolution of surface roughness layer thicknesses on microscopic, macroscopic, and "geometrical optic" lateral scales during the TCO fabrication process.
Distinct ETA Receptor Binding Mode of Macitentan As Determined by Site Directed Mutagenesis (2014)

The competitive endothelin receptor antagonists (ERA) bosentan and ambrisentan, which have long been approved for the treatment of pulmonary arterial hypertension, are characterized by very short (1 min) occupancy half-lives at the ET(A) receptor. The novel ERA macitentan, displays a 20-fold increased receptor occupancy half-life, causing insurmountable antagonism of ET-1-induced signaling in pulmonary arterial smooth muscle cells. We show here that the slow ET(A) receptor dissociation rate of macitentan was shared with a set of structural analogs, whereas compounds structurally related to bosentan displayed fast dissociation kinetics. NMR analysis showed that macitentan adopts a compact structure in aqueous solution and molecular modeling suggests that this conformation tightly fits into a well-defined ET(A) receptor binding pocket. In contrast the structurally different and negatively charged bosentan-type molecules only partially filled this pocket and expanded into an extended endothelin binding site. To further investigate these different ET(A) receptor-antagonist interaction modes, we performed functional studies using ET(A) receptor variants harboring amino acid point mutations in the presumed ERA interaction site. Three ET(A) receptor residues significantly and differentially affected ERA activity: Mutation R326Q did not affect the antagonist activity of macitentan, however the potencies of bosentan and ambrisentan were significantly reduced; mutation L322A rendered macitentan less potent, whereas bosentan and ambrisentan were unaffected; mutation I355A significantly reduced bosentan potency, but not ambrisentan and macitentan potencies. This suggests that--in contrast to bosentan and ambrisentan--macitentan-ET(A) receptor binding is not dependent on strong charge-charge interactions, but depends predominantly on hydrophobic interactions. This different binding mode could be the reason for macitentan's sustained target occupancy and insurmountable antagonism.
STUDY ON PL ENHANCEMENT OF <font>InGaAs</font>/<font>GaAs</font> QUANTUM WELL EMISSION BY GOLD NANOPARTICLE ARRAYS (2014)

In this paper, enhancement of photoluminescence (PL) intensity from InGaAs / GaAs quantum well (QW) caused by coupling effect of surface plasmon (SP) resonance generated by Au nanodisk arrays with QW emission is demonstrated experimentally. To increase the coupling efficiency, a thin layer of SiO 2 is introduced between Au nanodisk and GaAs surface. To match SP wavelength with QW emission wavelength (945 nm), Au nanodisk arrays with periodicity of 290 nm, radius of 70 nm, and thickness of 10 nm is fabricated. 2.17-fold enhancement is observed.
Three-dimensional cardiac architecture determined by two-photon microtomy (2009)

Cardiac architecture is inherently three-dimensional, yet most characterizations rely on two-dimensional histological slices or dissociated cells, which remove the native geometry of the heart. We previously developed a method for labeling intact heart sections without dissociation and imaging large volumes while preserving their three-dimensional structure. We further refine this method to permit quantitative analysis of imaged sections. After data acquisition, these sections are assembled using image-processing tools, and qualitative and quantitative information is extracted. By examining the reconstructed cardiac blocks, one can observe end-to-end adjacent cardiac myocytes (cardiac strands) changing cross-sectional geometries, merging and separating from other strands. Quantitatively, representative cross-sectional areas typically used for determining hypertrophy omit the three-dimensional component; we show that taking orientation into account can significantly alter the analysis. Using fast-Fourier transform analysis, we analyze the gross organization of cardiac strands in three dimensions. By characterizing cardiac structure in three dimensions, we are able to determine that the alpha crystallin mutation leads to hypertrophy with cross-sectional area increases, but not necessarily via changes in fiber orientation distribution.
Use of Susceptibility-Weighted Imaging (SWI) in the Detection of Brain Hemorrhagic Metastases from Breast Cancer and Melanoma (2016)

With the use of combined SWI and contrast-enhanced high-resolution T1 imaging, we found that presence of intratumoral brain hemorrhage is uncommon in micrometastases but common in metastases greater than 0.1 cm from breast cancer or melanoma. Large metastases commonly harbored hemorrhage, and this occurred more frequently in patients with melanoma than with breast cancer.
Fabrication of Food Bar Based on Compression and Molding Matrices (1969)

Abstract : Dried foods, some plasticized to prevent fragmentation, were compressed with appropriate binders into bars of approximately equal size, density and caloric content. Bars representing the following food items were designed, formulated, fabricated and evaluated for physical, chemical and sensory characteristics after storage for 3 months at 38C: (1) Citrus Fruit Drink (2) Hot Chocolate Beverage (3) Cream of Mushroom Soup (4) German Potato Salad (5) Cole Slaw (6) Pineapple-Cottage Cheese Salad (7) Welsh Rarebit (8) Crab Meat Cocktail (9) Chocolate Pudding (10) Pineapple Fruit Pudding. Complete information on all formulations and processing is supplied. In accordance with design requirements bars were rated by a taste panel as acceptable for consumption from the dry-compressed state and for consumption after rehydration for 20 minutes in water at 70C. (25C for items consumed at room temperature.) Bars were evaluated for cohesiveness, dimensional stability under pressure, ease of shear by the incisors and subsequent mastication. Observations on free fatty acids, peroxide value and browning (fluorescence units) are recorded for each bar at the time of fabrication and after the referenced storage.
Use of a cellular potyadenylation signal by viral transcripts in polyoma virus transformed cells (1982)

The DNA sequences at and around the junctions between viral and cellular DNA in the polyoma virus transformed mouse cell line, TS-A-3T3, have been determined. No common sequence specificity or structural features at the joins have been observed. The sequence indicates that the 94K truncated large T antigen found in TS-A-3T3 cells is a hybrid protein in which the carboxy-terminal 19 amino acids are encoded by adjacent host sequences. Moreover, the three early region transcripts initiated in viral sequences are also hybrid in nature and appear to utilize a host polyadenylation signal associated with the hexanucleotide, AATAAA, found 100 bp beyond a viral-host join.
FTY720 Versus Mycophenolate Mofetil in De Novo Renal Transplantation: Six-Month Results of a Double-Blind Study (2007)

Although FTY720 with FDC provided adequate protection from acute rejection the safety profile was less favorable for adverse events than current standard immunosuppression in de novo renal transplant patients.
Identification et caractérisation d'une séquence de type enhancer dans la région transcrite du génome de HIV-1 (1993)

Doctorat en Sciences
Continuous enrichment of low-abundance cell samples using standing surface acoustic waves (SSAW) (2014)

Cell enrichment is a powerful tool in a variety of cellular studies, especially in applications with low-abundance cell types. In this work, we developed a standing surface acoustic wave (SSAW) based microfluidic device for non-contact, continuous cell enrichment. With a pair of parallel interdigital transducers (IDT) deposited on a piezoelectric substrate, a one-dimensional SSAW field was established along disposable micro-tubing channels, generating numerous pressure nodes (and thus numerous cell-enrichment regions). Our method is able to concentrate highly diluted blood cells by more than 100 fold with a recovery efficiency of up to 99%. Such highly effective cell enrichment was achieved without using sheath flow. The SSAW-based technique presented here is simple, bio-compatible, label-free, and sheath-flow-free. With these advantages, it could be valuable for many biomedical applications.
An animated graphical simulator for the IEEE 1596 scalable coherent interface, with real-time extensions (2002)

As part of the Very High Speed Optical Networks (VHSON) Demonstration Program, a simulator has been developed. The Scalable Coherent Interface Network Interface Functional Simulator (SCINIFS) addresses the Institute of Electrical and Electronic Engineers (IEEE) standard 1596-1992 for the Scalable Coherent Interface (SCI). In addition, SCINIFS addresses the evolving work of IEEE project P1596.6, entitled SCI Real-Time (SCI/RT). The SCI/RT project addresses extensions to IEEE Standard 1596 that seek to enhance SCI's utility for real-time fault-tolerant computing applications. SCINIFS addresses the functional behavior and performance of SCI/RT nodes when connected in a ring. The development of the simulator, early results and future work to model SCI switches are described.
Application of optimal delays selection on parallel cascade hammerstein models for the prediction of RF-power amplifier behavior (2006)

In this work two different black-box modeling strategies are combined in order to achieve improved RF power amplifier (PA) models based on measured input/output signals. The model validation is here done within the low input back-off (IBO) region of the power amplifier, thus showing significant nonlinear operation. The figure of merit (FoM) applied is the normalized mean square error (NMSE). A rectangle constellation modulation, 16-QAM, is used as input signal, and the nonlinearities caused by the low IBO operating conditions of the PA distort the output constellation. The PA output signal used to estimate the model coefficients presented high distortion levels, requiring a model capable to also care for memory effects, as it will be seen in this article. It has been observed that the combination of a selection of the optimal delays values with parallel-cascade Hammerstein pseudo-inverse based models can improve the identification accuracy, leading to precise models. This condition is important regarding the design of efficient pre-distorters, once its performance is very sensitive to the model quality.
Experimental demonstration of an Optical-Sectioning Compressive Sensing Microscope (CSM) (2010)

In this paper we present the design and implementation of a Compressive Sensing Microscopy (CSM) imaging system, which uses the Compressive Sensing (CS) method to realize optical-sectioning imaging. The theoretical aspect of the proposed system is investigated using the mathematical model of the CS method and an experimental prototype is constructed to verify the CSM design. Compared to conventional optical-sectioning microscopes (such as Laser Scanning Confocal Microscopes (LSCMs) or Programmable Array Microscopes (PAMs)), the CSM system realizes optical-sectioning imaging using a single-pixel photo detector and without any mechanical scanning process. The complete information of the imaging scene is reconstructed from the CS measurements numerically.