gebhart/patrepeval huggingface dataset:
Measurement of Lipid Transfer Protein in 88 Apple Cultivars (2007)

Around 100-fold differences in LTP levels exist between apple cultivars. Whether the lowest observed levels of LTP warrant designation as hypo-allergenic requires more extensive confirmation by oral challenges. Determination of cultivar variation in LTP levels provides important information for growers and consumers. Comparison to earlier reported Mal d 1 levels in the same cultivars reveals that a designation as low allergenic does not always coincide for both allergens.
CHEMISTRY OF HOP CONSTITUENTS. PART XXXIII REACTIONS OF β-ACIDS (1969)

Reactions of β-acids in wort and in mineral acids and alkali have been investigated. Under acidic conditions colupulone lost isopentenyl side chains forming two isomeric butenols. Under alkaline conditions two after-bitter compounds were formed, the structures of which were elucidated. They were also found in an isomerized hop extract.
Numerical Simulation of the Cyclic Voltammogram of Polyacetylene (1995)

The measured cyclic voltammogram of a polyacety]ene-coated electrode bathed in an electrolyte solution was simulated numerically for various scan rates. The model used accounts for a modified Butler-Vo]mer-type heterogeneous kinetics at the electrode surface including a lateral interaction term which effects the observed hysteresis behavior. Within the polymer an electron flux obeying Ohm's law as well as electrolyte diffusion and migration is considered and Poisson's equation holds for electroneutrality. Donnan partition kinetics describes the flux and potential at the interface between the polymer and diffusion layer. Electrolyte diffusion is considered in the diffusion layer.
Imaging of human metaphase chromosomes by atomic force microscopy in liquid (2004)

Human metaphase chromosomes were observed using an intermittent contact mode of atomic force microscopy (AFM) in a phosphate-buffered saline solution to clarify their conformation close to that in the physiological state. In the AFM images in liquid, symmetric alternating ridges and grooves were evident on their surface of the paired sister chromatids. The number of the ridges and grooves were rather specific to the type of the chromosome. The structural changes of chromosomes caused by trypsin treatment were also directly observable using AFM in liquid. These results suggest that the intermittent contact mode AFM is useful not only for analyzing the structure of chromosomes in a liquid condition but also for studying the effect of chemical treatments on chromosomes in relation to their structural changes.
Buried Marking of Point Locations (1973)

An independent system to pinpoint buried equipment to depths of 10 ft has been developed. Its primary use will be rapid, accurate, and unambiguous location of underground utility services and survey points. The system has two components-a passive marker buried at a point of interest, and a hand-carried electronic interrogator. The marker, which is packaged as a sturdy peg, collects and reradiates low frequency energy when simulated by an interrogator. The peg design enhances pick-up range and location accuracy, and allows user identification by frequency. The interrogator is a sequentially switched transmitter-receiver that generates precise energy bursts and detects returned signals; optimum processing by frequency selection and cross correlation is used. The design of both components acknowledges an abusive field operating environment. Interrogator physical and operational details received particular emphasis, resulting in a simple functional instrument of unconventional shape.
Unilateral Vocal Fold Paralysis in Premature Infants after Ligation of Patent Ductus Arteriosus: Vascular Clip versus Suture Ligature (2009)

A hoarse infant with a birth weight of less than 1 kg who has undergone PDA ligation should be examined for unilateral IVFP. Vascular clips and suture ligature are associated with similar rates of IVFP.
A Layout-Aware Approach to Fault Injection for Improving Failure Mode Prediction (2015)

International audience
Topographic relief and sediment thickness: Their effects on the thermal evolution of the oceanic crust (1992)

We compiled a suite of 490 heat flow measurements from the Pacific Ocean in areas with less than 85 m of sediment. Heat flow patterns at different basement ages vary with topographic relief. Areas with reliefs < 300 meters are conductively blanketed at 40–60 m.y. and may stop convecting at 70–90 m.y. Areas with reliefs > 300 meters are conductively blanketed at 70–90 m.y. and convect out to ≥ 90–110 m.y.
Plasma YKL-40, a new biomarker for atrial fibrillation? (2009)

Patients with AF have significantly elevated levels of YKL-40. YKL-40 was not a significant predictor of successful CV to SR. Plasma levels of YKL-40 did not fall after restoration of SR.
Drosophilas Rückkehr (2012)

Wir haben in den beiden vorangegangenen Kapiteln über Gene beim Menschen berichtet. Tatsächlich standen in den Achtziger-Jahren die menschlichen Gene im Blickpunkt, nicht nur im Blickpunkt der medizinischen und biologischen Fachwelt, sondern auch der allgemeinen Öffentlichkeit, jedenfalls des Teils der Öffentlichkeit, der die Wissenschaftsseiten der Zeitungen las und sich die entsprechenden TV-Programme ansah. Aber damals begann viel, was über die Genetik des Menschen hinausging und die Biologie enorm bereichern, ja, erweitern und verändern sollte. Dabei kam wieder ein bewährtes Eine Anmerkung: α -Thalassämie Recht – Drosophila melanogaster.
La réponse des cellules aux stress : relation avec le processus de vieillissement et la pathologie. (1998)

La senescence replicative in vitro est caracterisee par un ralentissement puis un arret irreversible de la multiplication des types cellulaires proliferatifs. Des stress subletaux peuvent accelerer le processus de vieillissement cellulaire et entrainer l'apparition de ses principaux marqueurs que sont l'alteration morphologique, le raccourcissement des telomeres, la perte du processus proliferatif. L'etude fondamentale des processus cellulaires et moleculaires lies, en particulier, aux modifications irreversibles dues a l'effet de stress non letaux peut etre replacee dans le contexte des affections liees au vieillissement. Une interpretation globale fondee sur la theorie de la thermodynamique des systemes ouverts loin de l'equilibre permet d'expliquer comment des stress de diverses natures physico-chimiques peuvent entrainer un vieillissement accelere des cellules.
Phosphohexose Isomerase Activity of Cerebrospinal Fluid (1963)

The discovery of the enzymatic activity in the body fluids and the possibility of determining it by routine methods has enabled the solution of normophysiologic, pathophysiologic, and thereby also of diagnostic problems. The advent of the enzymatic era favored the conclusion that the behavior of the enzyme under the examination will be of pathognomonic significance for the determined disease so that some of the laboratory examinations will become superfluous. Today, however, it is evident that this is true only for a few enzymes and disease entities. In the vast majority of cases, the behavior of the given enzyme is only one of several diagnostic features. On the other hand, there are safe reasons to hope that a pathognomonic constellation of enzymes, belonging apparently to different metabolic systems, may be found for several disease entities. It is easy to understand that the blood serum was first attacked by enzymologists, with the
Etude comparée des effets anti-hépatotoxiques d’extraits d’<em>Argemone mexicana</em> L. (Papaveraceae), une plante utilisée dans le traitement traditionnel de la jaunisse au Burkina Faso (2012)

Argemone mexicana L. (Papaveraceae) fait l’objet de nombreuses indications thérapeutiques en médecine traditionnelle dans la région des Cascades au Burkina Faso. Dans une étude préliminaire de 2006, il a été mis en évidence une activité anti-hépatotoxique du décocté aqueux lyophilisé des feuilles chez le rat Wistar préalablement ictérisé par une administration de tétrachlorure de carbone CCl4 (0,5 mL/kg, i.p.). Dans la présente étude, les auteurs projettent de comparer les effets anti-hépatotoxiques de trois (03) extraits de la plante notamment deux extraits aqueux lyophilisés (décocté et macéré) et un extrait du totum  alcaloïdique; tous administrés à différents lots de rats rendus initialement ictériques par injection de l’hépatotoxique. La silymarine (100 mg/kg) a été utilisée comme produit de référence anti-hépatotoxique. Les trois extraits (250 mg/kg, p.o.) ont témoigné une action anti-hépatotoxique significative (p<0,05) objectivée par un pourcentage de réduction notable des marqueurs biochimiques enzymatiques notamment les transaminases (ASAT/GOT, ALAT/GPT), la phosphatase alcaline (PAL) et la bilirubine directe (DBil). Les pourcentages moyens de réduction d’hépato-toxicité induite ont été de 79,4% (silymarine), 69,73% (décocté lyophilisé), 70,63% (macéré lyophilisé) et 72% (totum alcaloïdique). Ces résultats illustrent d’une part la prééminence de l’action pharmacologique anti-hépatotoxique de l’extrait de totum alcaloïdique comparé aux extraits aqueux lyophilisés et d’autre part, l’effet des extraits pris isolément reste en deçà de celui de la silymarine.Mots clés: effet anti-hépatotoxique, argemone mexicana, extrait lyophilisé, silymarine
Diagnostic imaging capabilities of the Ocelot -Optical Coherence Tomography System, ex-vivo evaluation and clinical relevance (2015)

The study demonstrates equivalence of image acquisition and consistent physician interpretation of images acquired by the Ocelot and the Dragonfly OCT systems in-spite of distinct image processing algorithms and catheter configurations. This represents a dramatic shift away from both fluoroscopic imaging and diagnostic-only OCT imaging during peripheral arterial intervention towards therapeutic devices that incorporate real time diagnostic OCT imaging. In the clinical practice, these diagnostic capabilities have translated to best-in-class safety and efficacy for CTO crossing using the Ocelot catheter.
Wave Chaos Experiments with and without Time Reversal Symmetry: GUE and GOE Statistics (1995)

It has been predicted that in the semiclassical regime the level statistics of a classically chaotic system correspond to that of the Gaussian unitary ensemble (GUE) of random matrices when time reversal symmetry is broken. This Letter presents the first experimental test of this prediction. The system employed is a microwave cavity containing a thin ferrite strip adjacent to one of the walls. When a sufficiently large magnetic field is applied to the ferrite (thus breaking the time reversal symmetry) good agreement with GUE statistics is obtained. The transition from Gaussian orthogonal ensemble (GOE) (which applies in the absence of the applied field) to GUE is also investigated.
Mpox Virus is Inhibited By Nucleoside Analogues Including the Acyclic Phosphonates Tenofovir and Adefovir (2023)

ABSTRACT Mpox virus (MPXV) is an orthopoxvirus that causes the human disease mpox, which is characterized by fever, myalgia, and formation of rashes and lesions, and which garnered worldwide attention due to a global outbreak in 2022. In response to the outbreak, the antivirals tecovirimat, cidofovir, and brincidofovir have been used as emergency treatment for mpox. However, because of drug resistance and toxicity risks with those compounds, there is still a need for additional antivirals to treat orthopoxvirus diseases. Since cidofovir is a nucleoside analogue, we investigated a selection of other such compounds for antiviral activity against orthopoxviruses. We developed in vitro screening assays using fluorescent strains of vaccinia virus (VACV) and modified vaccinia Ankara (MVA) to measure the antiviral potency of test compounds. We found that tenofovir alafenamide and adefovir dipixovil, both acyclic phosphonates, had strong potential combinations of anti-orthopoxvirus activity and low toxicity after testing them against MVA and VACV, with EC 50 values in the single digit micromolar and nanomolar range, while other potential hits included trifluridine and two arabinosides. We then recapitulated the results with MPXV using a luciferase-based assay. These data reinforce the interest of repurposing nucleoside analogues as antivirals to treat poxvirus infections and provide a basis for high throughput screening and mechanistic and antiviral resistance studies.
Cellular patterns in the inner retina of adult zebrafish: Quantitative analyses and a computational model of their formation (2004)

The mechanisms that control cellular pattern formation in the growing vertebrate central nervous system are poorly understood. In an effort to reveal mechanistic rules of cellular pattern formation in the central nervous system, quantitative spatial analysis and computational modeling techniques were applied to cellular patterns in the inner retina of the adult zebrafish. All the analyzed cell types were arrayed in nonrandom patterns tending toward regularity; specifically, they were locally anticlustered. Over relatively large spatial scales, only one cell type exhibited consistent evidence for pattern regularity, suggesting that cellular pattern formation in the inner retina is dominated by local anticlustering mechanisms. Cross-correlation analyses revealed independence between the patterns of different cell types, suggesting that cellular pattern formation may involve multiple, independent, homotypic anticlustering mechanisms. A computational model of cellular pattern formation in the growing zebrafish retina was developed, which featured an inhibitory, homotypic signaling mechanism, arising from differentiated cells, that controlled the spatial profile of cell fate decisions. By adjusting the spatial profile of this decaying-exponential signal, the model provided good estimates of all the cellular patterns that were observed in vivo, as objectively judged by quantitative spatial pattern analyses. The results support the hypothesis that cellular pattern formation in the inner retina of zebrafish is dominated by a set of anticlustering mechanisms that may control events at, or near, the spatiotemporal point of cell fate decision.
Enhanced photorefractive effects with a de field and moving grating in GaP at 633 nm (1991)

Photorefractive (PR) devices have found applications in optical computing, image processing and pattern recognition [1–3] , because PR materials provide unique features such as real time operation, optical gain, storage, nonlinear operations, phase conjugation and correlation. New PR materials are being investigated in order to meet the device and system requirements of sensitivity, speed, and operation wavelength (e.g., response to the near infrared spectral range for systems operated with semiconductor lasers). Compound semiconductors may satisfy these requirements. For example, optical signal amplification by two-beam coupling and amplified phase-conjugate beam reflection by four-wave mixing have been reported in GaAs [4] and InP [5] at the wavelength of 1.06 μm. Recently, GaP [6–7] was shown to possess a relatively weak PR effect in the spectral range of 0.6 to 0.9 μm. In this manuscript we report enhancement of the PR effect in GaP using an externally applied electric field and moving grating. In particular, two- and four-wave mixing experiments were used to demonstrate a gain coefficient of Γ = 1.9 cm –1 and a phase conjugate reflectivity, R= 4.5%. In addition, several figures of merit of GaP, i.e., steady-state index change, absorption coefficient, response time and PR sensitivity were characterized.
Multicolor Two-photon Imaging of Endogenous Fluorophores in Living Tissues by Wavelength Mixing (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Stringari, L. Abdeladim, P. Mahou, G. Malkinson, S. Brizion, J. Galey, W. Supatto, R. Legouis, A. Pena, and E. Beaurepaire, "Multicolor two-photon imaging of endogenous fluorophores in living tissues by wavelength mixing," in Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optica Publishing Group, 2018), paper MF2A.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Purification, Characterization And Radioimmunoassay Of A New Antiheparin Protein Secreted By Rabbit Platelets (1981)

We isolated a platelet specific protein from rabbits for studying the usefulness of such proteins as marker for in vivo platelet activation in animals. The protein was purified by chromatography on heparin-agarose and on Sephadex G75 from the soluble release products of thrombin aggregated washed rabbit platelets. On heparin- agarose the protein eluted in front of rabbit PF4 at a salt concentration of about 0.9 M NaCl, and had a MW of about 20,000 dalton as judged by gel filtration. The purified protein migrated in SDS PAGE in the presence or absence of mercaptoethanol as a single band with a MW of <12,000 dalton. It had a heparin-neutralizing activity of 0.16 mg Polybrene/ mg and a pI of >9.5. A radioimmunoassay with second antibody precipitation was developed. Antisera were produced in goats. Plasma and serum levels were 26 ± 6 ng/ml (n = 16, x ± SD) and 2900 ± 960 ng/ ml (n = 8), respectively. Washed platelets contained 2.0 ng of the protein per 106 platelets. The protein was released in parallel to platelet aggregation induced by collagen. Plasma levels rose from 26 ± 8 ng/ml (n = 6) to 72 ± 29 ng/ml 30 s after i.v. injection of collagen into rabbits. After injection of the iodinated protein into rabbits (n = 4) the disappearance of radioactivity followed two-compartment kinetics with half-lives of 3.8 min and 137 min for the fast and slow component, respectively. No increase of plasma radioactivity was recorded after injection of 500 U heparin per rabbit after 3 hrs. At that time 51 ± 13 % of the injected radioactivity was recovered in the urine. This new rabbit platelet secretory protein shows similar but not identical biochemical and in vivo behaviour as human βTG.
Construction of Short Protocol Sequences with Worst-Case Throughput Guarantee (2010)

Protocol sequences are used in channel access for the multiple-access collision channel without feedback. A new construction of protocol sequences with a guarantee of worst-case system throughput is proposed. The construction is based on Chinese remainder theorem. The Hamming crosscorrelation is proved to be concentrated around the mean. The sequence period is much shorter than existing protocol sequences with the same throughput performance. The new construction reduces the complexity in implementation and also shortens the waiting time until a packet can be sent successfully.
Nexrutine <sup>®</sup> preserves muscle mass similar to exercise in prostate cancer mouse model (2019)

Muscle loss is a debilitating side effect to prostate cancer (PCa) experienced by nearly 60% of men. The purpose of this study was to test the hypothesis that Nexrutine<sup>®</sup> , a bark extract from the Phellodendrum amurense, can protect against prostate cancer induced muscle loss in a similar manner as exercise, using the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Forty-five, 8- to 10-week old TRAMP mice were randomized to either control, Nexrutine<sup>®</sup> (600 mg/kg pelleted in chow) or exercise (voluntary wheel running). Mice were serially sacrificed at weeks 4, 8, 12, and 20, at which time either the left or right gastrocnemius muscle was harvested, weighted, and frozen. Proteolysis inducing factor (PIF), ubiquitin, and NF-κB concentrations were quantified using ELISA kits. Nexrutine<sup>®</sup> and exercise were equally able to protect TRAMP mice against PCa-induced muscle loss (P = 0.04). Both interventions decreased intramuscular PIF concentrations at 20 weeks compared to control (P < 0.05). A treatment effect was also observed when all time points were combined with exercise significantly lowering PIF concentrations (P < 0.01). Exercise significantly lowered intramuscular ubiquitin concentrations in weeks 4, 8, and 20 compared to control mice (P < 0.001). A treatment effect was also observed with exercise significantly lowering ubiquitin compared to control mice (P < 0.001). No significant changes were observed for NF-κB. The results of this investigation demonstrate that PCa-induced muscle loss can be attenuated with the herbal supplement Nexrutine<sup>®</sup> . This investigation provides preliminary evidence to support continued research into Nexrutine<sup>®</sup> as a potential exercise analog in protecting against muscle loss.
X-ray resonant Raman spectroscopy (1995)

X-ray resonant Raman scattering presents great promise as a high-resolution spectroscopic probe of the electronic structure of matter. Unlike other methods, the technique avoids the loss of energy resolution resulting from the lifetime broadening of short-lived core-excited states. In addition, measurements of polarization and angular anisotropies yield information on the symmetries of electronic states of atoms and molecules. We studied the L{sub 3} edge of xenon, where the lifetime broadening is a major feature of the spectra recorded previously. X-ray fluorescence spectra were taken of both the L{alpha}{sub l,2} and L{beta}{sub 2,15} peaks over a range of energies from 10 eV below the edge to 40 eV above. These spectra show the evolution of resonant Raman scattering into characteristic fluorescence as the photon energy is scanned across the edge, and confirm several features of these spectra such as asymmetries in resonant peak shapes due to the onset of the ionization continuum. These results constitute the most comprehensive study of X-ray resonant Raman scattering to date, and were submitted for publication. Studies of other cases are under way, and new instruments that would match the unique characteristics of the APS - and thus render a new range of experiments possible - are under consideration.
Formation and relaxation kinetics of starch–particle complexes (2016)

The formation and relaxation kinetics of starch-particle complexes were investigated in this study. The combination of cationic nanoparticles in suspension and anionic starch in solution gave rise to aggregate formation which was studied by dynamic light scattering, revealing the initial adsorption of the starch molecules on the particle surface. By examining the stability ratio, W, it was found that even in the most destabilized state, i.e. at charge neutralization, the starch chains had induced steric stabilization to the system. At higher particle and starch concentrations relaxation of the aggregates could be seen, as monitored by a decrease in turbidity with time. This relaxation was evaluated by fitting the data to the Kohlrausch-Williams-Watts function. It was found that irrespective of the starch to particle charge ratio the relaxation time was similar. Moreover, a molecular weight dependence on the relaxation time was found, as well as a more pronounced initial aggregated state for the higher molecular weight starch. This initial aggregate state could be due to bridging flocculation. With time, as the starch chains have relaxed into a final conformation on the particle surface, bridging will be less important and is gradually replaced by patches that will cause patchwise flocculation. After an equilibration time no molecular weight dependence on aggregation could be seen, which confirms the patchwise flocculation mechanism.