gebhart/patrepeval huggingface dataset:
Abstract 16854: End-Stage Renal Disease Associated With Metabolic Syndrome: A Study of Biomarkers Relevant to Cardiovascular Risk (2014)

Introduction: Metabolic syndrome (MS) represents a cluster of cardiovascular risk factors which contribute to myocardial infarction and stroke in end stage renal disease (ESRD) patients. Several metabolic biomarkers have been identified and their circulating levels provide a better understanding of the pathogenesis of MS/ESRD. The purpose of this investigation is to profile biomarkers of MS in ESRD patients. Materials and Methods: Plasma samples from 87 patients with ESRD undergoing maintenance hemodialysis and 50 normals were collected prior to a routine session. These samples were profiled for metabolic biomarkers using protein chip bioarray technology. The protein chip array was comprised of several biomarkers of MS. All results were compiled in terms of group means +/- 1 SD (SEM) and statistically analyzed. Results: In comparison to the normal samples, the ESRD group showed marked increase in circulating levels of all biomarkers. TNFa (47.4 +/- 18.3 vs 4.1 +/- 1.1 ng/mL) and IL-6 (7.8 +/- 9.1 vs 0.8 +/- 0.4 ng/mL) showed the most pronounced increase. C-peptide (14.5 +/- 4.1 vs 2.8 +/- 1.6 ng/mL), leptin (29.7 +/- 29.2 vs 5.2 +/- 7.9 ng/mL), resistan (16.1 +/- 6.0 vs 2.3 +/- 0.7 ng/mL) and ferritin (274 +/- 57 vs 57 +/- 63 ng/mL) showed a 5-fold increase in the ESRD group compared to normal. PAI-1 (5.4 +/- 5.2 vs 2.9 +/- 2.5 ng/mL), IL-1a (1.3 +/- 1.7 vs 0.35 +/- 0.07 ng/mL) and insulin (32.1 +/- 17.3 vs 17.1 +/- 1.7 ng/mL) showed modest increase in the ESRD patients. The increase in all of the MS biomarkers in the ESRD patients were highly significantly elevated, p <0.05. Conclusion: The specific biochip array for MS allows the selective determination of various biomarkers associated with this syndrome in the ESRD patients and normals. Parallel increase in resistan, insulin, C-peptide, and leptin points to the derangement of glucose metabolism in these patients. Increase IL-1a, TNFa, and ferritin suggests the upregulation of an inflammatory process. PAI-1 increase suggests a fibrinolytic deficit. The parallel derangement of the inflammatory process and metabolic syndrome contributes to the cardiovascular and cerebrovascular complications in these patients.
Experience with the intensive care management of organophosphate insecticide poisoning. (1981)

During the 5-year period 1975-1979, 41 out of a total of 157 patients treated for 'organophosphate poisoning' (26%) were admitted to intensive care units. Treatment comprised atropine (0,02-0, mg/kg every 15-30 minutes or 0,02 - 0,08 mg/kg/h by continuous intravenous infusion), intermittent mandatory ventilation (IMV) with continuous positive airways pressure (CPAP) where indicated, and general supportive measures including adjustment of electrolyte, fluid and acid-base balance. Oxime-type cholinesterase reactivators were administered to 10 patients. Serum cholinesterase (S-ChE) and erythrocyte acetylcholinesterase (E-AChE) activities were monitored continuously. Despite intensive therapy, 5 patients (12%) died. IMV and CPAP proved to be a near-ideal method of mechanical ventilation. Atropine administered by continuous infusion was found to be superior to intermittent administration during the acute phase, while oral administration of atropine proved adequate thereafter. Oxime-type reactivators were not found to be of any significant value. Clinical recovery (the point at which atropine could safely be discontinued) generally correlated with a recovery of E-AChE activity to 30% or more of normal. Sudden deterioration due to possible 'endogenous re-intoxication' was observed in some patients days after the initial exposure to an organophosphate insecticide.
The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition. (1996)

After DNA viruses enter the nucleus, they initiate a transcriptional cascade which is followed by replication. We investigated whether these processes take place at specific nuclear sites or, as suggested by the mode of entry, randomly throughout the nucleus. Three distinct nuclear domains, nuclear factor-1 sites, coiled bodies, and nuclear domain 10 (ND10), were used as markers to investigate the relative position of DNA virus replication sites. We found that all three nuclear domains had a very high spatial correlation with each other in uninfected cells. After adenoviral infection, nuclear factor 1 and coiled bodies were found associated with some viral replication domains. Simian virus 40 begins replication adjacent to ND10 but adenovirus 5 and herpes simplex type 1 modified ND10s before replication. Adenovirus E4orf 3 gene deletion mutants retain ND10 and begin replication at the peripheries of ND10. The same was found for the herpes simplex virus type 1 immediate early gene 1 mutants. That the deposition and replication of adenovirus 5 and herpesvirus type 1 at ND10 was not a mutant phenotype was confirmed by finding the input wild-type virus juxtaposed to ND10. The transport of viral genomes to ND10 does not require viral gene expression. Thus, the peripheries of ND10 represent preferred sites where early steps of transcription and replication of at least three DNA virus families take place, suggesting a new set of functional properties for this large nuclear domain.
Die wirtschaftsverfassungsrechtliche Offenheit und Neutralität des Grundgesetzes (1978)

In der mehr als 25-jährigen Spruchpraxis des Bundesverfassungsgerichtes nehmen Entscheidungen zur Wirtschaftsverfassung einen wichtigen Platz ein, auch wenn sie nicht so stark in das politische Bewußtsein gedrungen sind wie Entscheidungen etwa auf dem Gebiet der Wehr- und der Hochschulverfassung. Es hat eigentlich kaum ein wirtschaftpolitisches Lenkungs- oder Organisationsgesetz gegeben, vom Kartellrecht abgesehen, das dem Bundesverfassungsgericht, meistens im Rahmen von Verfassungsbeschwerden der betroffenen Unternehmen, nicht zur Nachprüfung vorgelegt wurde. Die Spruchpraxis des Bundesverfassungsgerichtes war, wie an anderer Stelle ausgeführt (Reich 1977, S. 116), weitgehend ambivalent geblieben. Das Bundesverfassungsgericht erkennt dabei dem demokratisch und sozialstaatlich legitimierten Gesetzgeber einerseits weitgehende Interventionsbefugnis in die Abläufe des Marktgeschehens und in die Organisation der Marktsubjekte zu, nimmt dies jedoch durch eine extensive Grundrechtskontrolle, durch Ausdehnung des sogenannten Verhältnismäßigkeitsgrundsatzes und durch Anwendung allgemeiner Rechtsstaatsprinzipien teilweise wieder zurück. Es konnte eine asymmetrisch strukturierte doppelte Instrumentalität in der wirtschaftsverfassungsrechtlichen Spruchpraxis des Bundesverfassungsgerichtes festgestellt werden: die eine Instrumentalität des Wirtschaftsrechtes, die Freiheitsräume für die Marktsubjekte, insbesondere Unternehmen schafft, genießt tendenziell den Vorrang vor der anderen Instrumentalität, die aufseiten des Staates, genauer des politisch legitimierten Gesetzgebers, Einschränkungen und Bindungen der Unternehmensfreiheiten an Ziele des Gemeinwohles, des Sozialstaates und der wirtschaftlichen Strukturpolitik vorsieht.
High power ferrite phase shifters for phased array radars (1992)

The criteria for selecting the nonreciprocal toroid phase shifter over its major competitors, the dual-mode ferrite phase shifter and the rotary field phase shifter, are given. The paper describes the nonreciprocal ferrite phase shifter from a design point of view and addresses the calibration and testing procedures required for optimum performance. The key factors and considerations influencing the design of the microwave and electronic portions are presented to clarify and understand the capabilities, limitations and interface requirements for this type.
Relationship between Arterial Stiffness and the Risk of Coronary Artery Disease in Subjects with and without Metabolic Syndrome (2007)

We examined the influence of metabolic syndrome (MetS) on the relationship between arterial stiffness and the risk of coronary artery disease (CAD). In 396 subjects (age, 63+/-11 years) who underwent coronary angiography, multiple linear regression analysis demonstrated that the brachial-ankle pulse wave velocity (PWV), but not the presence of MetS, was a significant determinant of the number of diseased coronary arteries (beta=0.10, p<0.05), even though both the brachial-ankle PWV and the number of diseased coronary arteries were higher in subjects with MetS (n=100) than in those without MetS (n=296). However, in subjects with MetS, multiple linear regression analysis demonstrated that the brachial-ankle PWV was not a significant determinant of the number of diseased coronary arteries. The brachial-ankle PWV values were classified into tertile ranges in subjects with and without MetS. The number of diseased coronary arteries increased significantly with an increase in the tertile number of the brachial-ankle PWV in the subjects without MetS (tertile 1=1.00+/-0.86, tertile 2=1.29+/-1.01, and tertile 3=1.45+/-1.05), but not in those with MetS. In conclusion, the results of this study suggest that arterial stiffness is a marker of the risk of CAD in subjects without MetS, whereas in subjects with MetS, the syndrome may directly produce clinically significant atherosclerotic stenosis of the coronary arteries independent of its significant promotion of the development of coronary atherosclerosis via an increase of arterial stiffness.
Transient dynamics of multiplexed short-pulse amplification in KrF (1988)

Time-dependent calculations of multiplexed short-pulse amplification are presented which show that cascaded short pulses in KrF lasers, with an appropriate time interval between the pulses, can extract energy with only a small cost in extraction efficiency as compared to a single long pulse. This dynamic characteristic of KrF* permits the design of a novel, simpler angular multiplexing system. Calculations include nonsaturable and saturable absorption, amplified spontaneous emission effects, and an end mirror for double-pass amplification. The dependence of the extraction efficiency and the energy gain on the time interval and pulse shape are calculated.
Effects of dietary fibre and olestra on regional apparent viscosity and water content of digesta residue in porcine large intestine (2000)

Relatively small changes in water content result in large changes in digesta residue/stool apparent viscosity. Dietary fibre increased digesta residue/stool water content throughout the bowel, resulting in softer digesta residue/stool. In contrast, olestra decreased stool water content, yet had a similar stool softening effect compared to dietary fibre.
Dynamics of Excitons in GaN-AlGaN MQWs with Varying Depths, Thicknesses and Barrier Widths (1999)

Picosecond time-resolved photoluminescence is used to investigate the recombination dynamics of excitons in samples which all contain four GaN–AlxGa1—xN quantum wells of respective widths of 4, 8, 12 and 16 molecular monolayers, grown by molecular beam epitaxy. The compositions and thicknesses of the barriers have been varied, in order to change the electric fields induced by piezo- and pyro-electric effects. The dependences of experimental decay times with barrier characteristics indicate the presence of efficient inter-well carrier escaping. Calculations of electronic tunneling times versus barrier width show that the present carrier escaping is enhanced by some additional process, such as scattering by impurities or composition fluctuations in the barriers.
Textures of Sheet in AA3003 Aluminum Alloy Under Biaxial Stretching (2000)

In this paper, the textures are determined under plane strain tension, nonequi‐biaxial stretching and equi‐biaxial stretching. The changes of the major texture components in the sheet are analyzed and discussed. It is found that under plane strain tension, the strength of the {110}〈112〉 component increases by more than four times followed by the {110}〈111〉, whereas the fraction of {112}〈111〉 component falls gradually. In the sample deformed with a strain ratio intermediate between these of plane strain tension and equibiaxial stretching, the textural change is relatively small. Under equi‐biaxial stretching, there is a big increase in the {110} rolling plane components with the peak at {110}〈111〉 orientation. The strength of the other components falls rapidly ( e.g. {110}〈112〉) or remains low ( e.g. {112}〈111〉).
ChemInform Abstract: Trimethylchlorosilane and Water. Convenient Reagents for the Regioselective Hydrochlorination of Olefins. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The biogenesis of muscle glycogen: regulation of the activity of the autocatalytic primer protein. (1990)

Glycogen synthesis in rabbit muscle is initiated by an autocatalytic, self-glucosylating protein (SGP). This creates a maltosaccharide primer on itself that in turn primes glycogen synthesis. Here we describe the powerful allosteric inhibition of autocatalysis by ATP and ADP, sufficient, at the physiological concentration of ATP in muscle, to inhibit autocatalysis. We also examined inhibition of self-glucosylation by analogues of the substrate UDPglucose. One of them, UDPxylose, acts as an alternative substrate and serves to block glucosylation. An improved purification procedure for the SGP is also described.
ON THE DEFORMATION BAND IN REDRAWN POLYETHYLENE FILM (1967)

When a drawn polyethylene film is redrawn obliquely to the direction of original drawing, its deformation mechanism varies with the structure of original drawn film which is dependent upon the direction of original drawing of the film with a-axis orientation.Clear deformation bands are formed when the film which is originally drawn parallel to the machine direction and whose (100) planes are nearly parallel to the plane of the film, is redrawn obliquely at room temperatnre. But as the temperature of redrawing is raised above 70°C, clear deformation bands can not be formed in the film redrawn obliquely and are formed in the film redrawn nearly perpendicular to the direction of original drawing. These kink bands have the kink angles of 40_??_60 degrees and are different from ones formed in the film redrawn obliquely at room temperature.Also deformation bands are not formed in the films originally drawn perpendicular to the machine direction when they are obliquely redrawn. There are remarkable differences in load-elongation curves and values of birefringence of redrawn regions between these two types of deformation that is deformation accompanied by the formation of kink band and that without clear kink band when the drawn films are redrawn obliquely.
Radiofrequency equipment and scientific basis for radiofrequency ablation (2008)

Minimally invasive strategies for tumor ablation, such as radiofrequency (RF) thermal ablation, have now gained prominent attention for the focal destruction of hepatic malignancies and are considered mainline therapies for some focal malignancies. Advantages of minimally invasive therapies compared to surgical resection include the anticipated reduction in morbidity and mortality, lower cost, the ability to perform procedures on outpatients, and the potential application in a wider spectrum of patients, including non-surgical candidates.
Analysis and applications of microstrip exponentially tapered lines (1972)

This paper presents experimental and analytical work on the application of microstrip exponentially tapered lines (METL) to microwave power transistor characterization and evaluation. Previous published work on tapered transmission lines has dealt mainly with their properties as filters, or as transitions between uniform lines of differing characteristic impedances. This article treats the METL as a transformer for complex (not only real) loads.
New Materials: Non-Equilibrium Synthesis by Laser (1989)

Synthesis of nonequilibrium phases provides an opportunity to engineer new materials with novel properties. The technique of laser surface modification (LSM) provides a unique means of synthesizing novel non-equilibrium materials by taking advantage of the inherent rapid heating and cooling rate of the process. LSM can be used to obtain specific surface properties significantly different from bulk properties. Also, by depositing multiple layers by LSM, nonequilibrium materials with specific properties can also be synthesized in near net shape. This approach is now pursued for various applications, including aerospace engine and structural components for high temperature service and wear and corrosion resistant components for chemical and engineering industries. This paper describes a synthesis of Ni-Al-Cr-Hf alloys with extended solid solution of Hf by laser cladding techniques. A 10 kW CW CO2 laser with mixed powder feed was used for the cladding process. Microstructural studies reveal the formation of dendrites with about 11–14 wt % Hf along with eutectic structure in the interdendritic zones. Isothermal oxidation tests revealed improved oxidation resistance at 1200°C compared to conventional nickel superalloys. A mathematical model is also reported for the prediction of the effect of laser process parameters on non-equilibrium phase diagram.
Distinct Differences Between Morphine‐ and [<scp>d</scp>‐Ala<sup>2</sup>,<i>N</i>‐MePhe<sup>4</sup>,Gly‐ol<sup>5</sup>]‐Enkephalin‐ μ‐Opioid Receptor Complexes Demonstrated by Cyclic AMP‐Dependent Protein Kinase Phosphorylation (1998)

The present study demonstrates a conditional, agonist-dependent phosphorylation of the mu-opioid receptor (MOR-1) by cyclic AMP-dependent protein kinase (PKA) in membrane preparations of MOR-1-transfected neuroblastoma Neuro2A cells. Opioid agonist-dependent phosphorylation occurs in a time- and concentration-dependent manner (EC50 approximately 40 nM) and can be abolished by the receptor antagonist naloxone. Stoichiometric analysis indicates incorporation of a maximum of 6 mol of phosphate/mol of receptor in the presence of 1 microM morphine and 6 nM PKA. Although morphine and related alkaloids as well as some peptide agonists (PLO17 and beta-endorphin) stimulated phosphorylation of MOR-1 by PKA, the potent mu-opioid-selective peptide [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin (DAMGO) or other enkephalin analogues such as [D-Ala2]-Met5-enkephalinamide (DALA), [D-Ala2,D-Leu5]-enkephalin (DADLE), and Met5-enkephalin had no effect. The lack of the effect of DAMGO on MOR-1 phosphorylation state was evident also after chronic pretreatment. These results suggest the existence of different agonist-dependent conformations of MOR-1. Furthermore, phosphorylation may be a useful parameter with which to identify different agonist-receptor conformations.
Welcome for the IFCPC (2003)

We regret to inform you that we have received news of the death of Dr. Andrew Östör of Australia. An obituary will be published in the next issue.
Characterization and Analysis of Volatile Fingerprint of 13 Different Commercial Essential Oils with GC-MS and Chemical Gas Sensors (2018)

Essential oils are mixtures of compounds obtained from plants, including flowers, roots, bark, leaves, seeds,peel, fruits, wood, that have risen up in the last decades thanks to their beneficial properties as antibacterial, antifungal and anti-inflammatory agents. The aim of this study was to characterize and analyze 13 different commercial essential oils with two different techniques. The first is GC-MS, coupled with SPME, thanks to which 204 different VOCs have been identified. The results show that a total of 95 compounds was found only in one oil, while the others were found with different frequencies in many of them. The most represented class is that of terpenes, as widely reported in literature. The second technique is based on an array of chemical gas sensors. This system was used to investigate whether sensors are able to identify these products. It turned out that basil, cinnamon and carnation are the most identifiable oils with different number and typology of sensors, especially tin oxide and copper oxide nanowires, while cayeput and thyme are more mistakable samples. Thanks to this detailed study, it has been possible to reach and obtain novel insights for the future development of this type of research.
p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-κB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche (2014)

In the bone marrow (BM), hematopoietic progenitors (HPs) reside in specific anatomical niches near osteoblasts (Obs), macrophages (MΦs), and other cells forming the BM microenvironment. A connection between immunosurveillance and traffic of HP has been demonstrated, but the regulatory signals that instruct the immune regulation of HP circulation are unknown. We discovered that the BM microenvironment deficiency of p62, an autophagy regulator and signal organizer, results in loss of autophagic repression of macrophage contact-dependent activation of Ob NF-κB signaling. Consequently, Ob p62-deficient mice lose bone, Ob Ccl4 expression, and HP chemotaxis toward Cxcl12, resulting in egress of short-term hematopoietic stem cells and myeloid progenitors. Finally, Ccl4 expression and myeloid progenitor egress are reversed by deficiency of the p62 PB1-binding partner Nbr1. A functional "MΦ-Ob niche" is required for myeloid progenitor/short-term stem cell retention, in which Ob p62 is required to maintain NF-κB signaling repression, osteogenesis, and BM progenitor retention.
Parameters optimization for the generation of a keyhole weld pool during the start-up segment in variable-polarity plasma arc welding of aluminium alloys (2000)

Stable weld formation is still one of the goals pursued in variable-polarity plasma arc welding (VPPAW) of aluminium alloys. Basically, VPPAW is divided into three segments: The start-up segment, during which the keyhole is generated, the main body segment, during which the keyhole is dynamically maintained, and the terminal segment, during which the keyhole collapses and the crater is filled. Very often, a smooth transition cannot be made from the start-up segment to the main body segment, and the weld easily fails because the keyhole weld pool is not properly generated. This paper explores four different combinations of plasma gas and welding current for generating a smooth transition from the start-up segment to the main body segment in VPPAW. The keyhole weld pool is categorized as one of three types: heat conduction mode, strong force mode or heat and force mode. The heat and force mode of the keyhole weld pool can be generated by raising the gas flowrate, raising the current or by raising both the gas and current. An increase in the plasma gas flowrate accompanied with an increase in the welding current is the best combination for generating a smooth transition during the start-up segment, which results in only a few double arcs and no short circuiting between the nozzle and the workpiece. The quality of the initial weld bead can be guaranteed using this approach.
Double Hydroxylation Reaction for Construction of the Corticoid Side Chain: 16α‐Methylcortexolone (2003)

Abstract Double hydroxylation reaction for construction of the corticoid side chain: 16α‐methylcortexolone intermediate: (Z)‐16α‐methyl‐20‐trimethylsiloxy‐4,17(20)‐pregnadien‐3‐one product: 16α‐Methylcortexolone