gebhart/patrepeval huggingface dataset:
Longitudinal Comparison of Visual Acuity as Measured by ETDRS Chart and by Potential Acuity Meter in Eyes with Macular Edema and Its Relationship with Macular Sensitivity and Thickness (2013)

Purpose:To conduct a longitudinal comparison of visual acuity measured by the ETDRS chart and by the Potential Acuity Meter (PAM) in eyes with macular edema under medical treatment for edema and its relationship with macular sensitivity and thickness Methods:Patients with macular edema (ME) are enrolled in an ongoing prospective study. Patients have follow up visits every 2-4 weeks. At the initial and each follow up visit, best refractive correction for all patients is determined using the ETDRS protocol, and best-corrected visual acuity (BCVA) is assessed using the ETDRS chart as well as by the PAM. Macular sensitivity and thickness are measured by an automatic fundus perimetry/tomography system [OPKO/OTI]. The relationships between BCVA measurements with each of the two systems and macular sensitivity/ thickness are evaluated using mixedeffect modeling. Results:Thirty-eight eye-visits of 14 patients are included in the study. Five patients (10 eyes) had one follow up visit after the initial one. Ages range from 49 to 84 years (median: 66 yrs). BCVA using the HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH QUICK SEARCH: [advanced] Go Author: Keyword(s): Year: Vol: Page: Institution: Johns Hopkins University Sign In as Member
Loop Stereochemistry and Dynamics in Transfer RNA (1983)

The stereochemistry and the dynamics of two loops of yeast tRNA-asp, the thymine loop and the anticodon loop, are compared in the hope of a better understanding of the relationships between loop sequence and loop topology. Both loops are seven residues long and both present sharp turns after the second residue, U33 and psi 55, stabilized by hydrogen bonds between N3-H of the pyrimidine and the phosphates of C36 and A58 and stacking interactions of the pyrimidine ring with the phosphates of U35 and A57, respectively. In the thymine loop, the two purines following C56, A57 and A58, open up to leave space for the intercalation of the first invariant guanine residue of the D-loop, while the two pyrimidine bases, which follow A58, turn away from the stacking pattern of the thymine arm and stack instead with the last base pair of the dihydrouridine arm A15-U48. In the anticodon loop, however, the bases G34 to C38 form an helical stack in continuity with the anticodon stem on the 3'-end. At the same time C36 forms Watson-Crick hydrogen bonds with G34 of a twofold symmetrically related molecule. The anticodon-anticodon base pairing interactions between symmetrically-related molecules are stabilized by stacking with the modified base G37 on both sides of the triplet. Some comparisons are made with the structure of yeast tRNA-phe and some implications about the structure of mitochondrial tRNAs are discussed.
Enhanced self-doubling efficiency in directly-pumped Nd-activated non-linear crystals: case of GdCOB (2002)

The possibility to enhance the self-doubling emission characteristics in Nd-activated non-linear crystals by direct pumping into the emitting level is discussed. A marked improvement is reported with respect to the traditional 4F5/2 pump for Nd:GdCOB.
Effects of deciliation of tubulin messenger RNA activity in sea urchin embryos. (1978)

Sea urchin embryos contain a large cytoplasmic pool of microtubular protein, from which they can regenerate cilia several times without the need for synthesizing additional tubulin. The present studies were initiated to determine if a requirement for new tubulin synthesis can be induced by depleting this pool through repeated cycles of deciliation. By the third round of deciliation, there is a 2- to S-fold increase in the rate of incorporation of r%]methionine into a- and &tubulin. To determine if this enhanced synthesis of tubulin is due to an increase in cytoplasmic levels of translatable tubulin mRNA, poly(A)-containing RNA was isolated from control and 5 x -deeiliated embryos by phenol/chloroform extraction and oligo(dT)-affinity chromatography. Translation of these RNAs in a wheat germ proteinsynthesizing system revealed a 2- to a-fold higher rate of e- andg-tubulin formation in the presence of poly(A)containing RNA from deciliated embryos. When the deciliation experiments were carried out in the presence of 100 pg/ml of actinomycin D (sufficient to inhibit RNA synthesis by greater than 95%), the enhanced rate of tubulin formation no longer occurred, although tubulin continued to be synthesized at control rates. Actinomycin D was also found to significantly inhibit the regeneration of cilia relative to nontreated organisms, but only after embryos were subjected to two to three rounds of deciliation. Since these results suggested the possible existence of control at the level of gene transcription, double label experiments were carried out to determine if the specific activity of labeled tubulin mRNA is enhanced in deciliated embryos. Deciliated and control embryos were labeled with [“HI- and [14C]uridine, respectively, and the polysomal poly(A)-containing RNA isolated and fractionated both by sodium dodecyl sulfate-sucrose gradient centrifugation and polyacrylamide gel electrophoresis. In both cases, a peak in the ‘H/14C ratio was observed with a sedimentation coefficient slightly larger than 18 S. When these RNA fractions were translated in the wheat germ cell-free system, this peak in ‘H/14C ratio was found in both cases to correspond to the peak in tub.ulin mRNA activity, suggesting that the specific activity of tubulin mRNA is elevated in deciliated embryos. These results, considered along with the actinomycin data, are consistent with the hypothesis that the increase in the level of translatable tubulin mRNA which occurs as
Double-reservoir rotoevaporation vessel for residue analysis (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDouble-reservoir rotoevaporation vessel for residue analysisThomas W. May and David L. StallingCite this: Anal. Chem. 1979, 51, 1, 169–170Publication Date (Print):January 1, 1979Publication History Published online1 May 2002Published inissue 1 January 1979https://pubs.acs.org/doi/10.1021/ac50037a050https://doi.org/10.1021/ac50037a050research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stereoselective synthesis of cis-4-(substituted) monobactams from ethyl acetoacetate (1989)

The stereoselective synthesis of cis-3-amino-4-methyl-2-oxoazetidine-1-sulphonic acid (25) from ethyl acetoacetate is described. Nitrosation of this compound and reduction of the resulting oxime gave the corresponding amine, which after treatment with different acyl halides, yielded the acylamino derivatives (6)–(8). Condensation with p-anisidine gave the enamines (12)–(14), which were then reduced to the β-amino acid esters (15)–(17). Stereoselective cyclization with Grignard reagents as base, and appropriate deprotection and sulphonation of the resulting β-lactams (18)–(20), led to the title compounds.
Apparent hydrodynamic thickness of densely grafted polymer layers in a theta solvent (1997)

We study the drainage of a near-theta solvent through densely grafted polymer layers and compare to recent notions that these layers display little permeability to solvent flow at surface separations less than a “hydrodynamic thickness.” The solvent is trans-decalin (a near-theta solvent at the experimental temperature of 24°C). The polymer is polystyrene (PS) end-attached to two opposed mica surfaces via the selective adsorption of the polyvinylpyridine (PVP) block of a PS-PVP diblock copolymer. The experimental probe was a surface forces apparatus modified to apply small-amplitude oscillatory displacements in the normal direction. Out-of-phase responses reflected viscous flow of solvent alone—the PS chains did not appear to contribute to dissipation over the oscillation frequencies studied. The value of the hydrodynamic thickness (RH) was less than the coil thickness (Lo) measured independently from the onset of surface–surface interactions in the force-distance profile, implying significant penetration of the velocity field into the polymer layer. As the surface–surface separation was reduced from 3Lo to 0.3Lo, the apparent hydrodynamic thickness (R) decreased monotonically to values R ≪ RH. Physically, this indicates that the “slip plane” moved progressively closer to the solid surfaces with decreasing surface–surface separation. This was accompanied by augmentation of the effective viscosity by a factor of up to approximately 5, indicating somewhat diminished permeability of solvent through the overlapping polymer layers. Similar results hold for the flow through surface-anchored polymers in a good solvent. It is interesting to note the strong stretching of densely end-grafted polymers in a theta solvent. © 1997 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 35: 2961–2968, 1997
Electron avalanches and diffused γ-mode in radio-frequency capacitively coupled atmospheric-pressure microplasmas (2009)

Copyright 2009 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the authors and the American Institute of Physics. This article appeared in the journal, Applied Physics Letters, and may be found at: http://link.aip.org/link/?APPLAB/95/031501/1
Strain C3H-A <sup>vy</sup> fB Mice: Ninety Percent Incidence of Mammary Tumors Transmitted by Either Parent (1970)

Mammary tumorigenesis in C3H-A(vy)fB female mice is not due to milk-borne mammary tumor virus but to factors transmitted at conception. Prominent among these is the A(vy) gene which may increase the virulence or transmissibility of a variant of mammary tumor virus vertically transmitted by either parent, or may increase the tumorigenic response of the mammary tissue. These factors together with the influence of hormones of pregnancy resulted in the high incidence observed.
On the Pitfalls of End-to-End Encrypted Communications (2017)

Many widely used Internet messaging and calling apps, such as WhatsApp, Viber, Telegram, and Signal, have deployed an end-to-end encryption functionality. To defeat potential man-in-the-middle attackers against the key exchange protocol, the approach crucially relies upon users to perform a code verification task whereby each user must compare the code (a fingerprint of the cryptographic keys) computed by her app with the one computed by the other user's app and reject the session if the two codes do not match.
Preparation, Characterization, and Analytical Application of Ramipril Membrane‐Based Ion‐Selective Electrode (2009)

The fabrication and electrochemical evaluation of two PVC membrane-based Ion-Selective electrodes responsive for ramipril drug have been proposed. The sensitive membranes were prepared using ramipril-phosphomolibdate and ramipril-tetraphenylborate ion-pair complexes as electroactive sensing materials in plasticized PVC support. The electrodes based on these materials provide near-Nernestian response (sensitivity of 53 +/- 0.5-54 +/- 0.5 mV/concentration decade) covering the concentration range of 1.0 x 10(-2)-1.0 x 10(-5) mol L(-1) with a detection limit of 3.0 x 10(-6)-4.0 x 10(-6) mol L(-1). The suggested electrodes have been successfully used in the determination of ramipril drug in some pharmaceutical formulations using direct potentiometry with average recovery of >96% and mean standard deviation of <3% (n = 5).
High-speed InP/InGaAs DHBTs with ballistic collector launcher structure (2002)

We demonstrate high-speed InP/InGaAs double-heterojunction bipolar transistors (DHBTs) with significantly improved collector carrier transport. The proposed collector design scheme allows for using moderate collector thickness to achieve high f/sub max/ (/spl sim/300 GHz) while maintaining high f/sub T/ (/spl sim/200 GHz). The DHBTs will meet the demand of ultra-high-speed applications for both high f/sub T/ and high f/sub max/.
PD27 HYDROGEN PEROXIDE ACTS AS AN ENDOGENOUS ELICITOR FOR PHYTOALEXIN PRODUCTION (1988)

Antibody-drug conjugates (ADCs) belong to a promising class of biopharmaceuticals in which target-killing of tumor cells was achieved by marrying the potency of the cytotoxic payload with the tumor specificity of the antibody. Here we developed a novel ADC (ZV0508) that targets 5T4 oncofetal antigen, which is overexpressed in many carcinomas on both bulk tumor cells and cancer stem cells. A novel cytotoxic payload called Duostatin-5 (Duo-5) which was derived from monomethyl auristatin F (MMAF) was attached to a 5T4 targeting antibody (ZV05) by interchain cysteine cross-linking conjugation via a disubstituted C-Lock linker. We have investigated the antitumor efficacy of ZV0508 by in vitro and in vivo studies, and compared its antitumor activity with ZV05-mcMMAF (ZV0501), in which MMAF was linked via a conventional noncleavable maleimidocaproyl linker. As results, ZV0508 exhibited ideal antiproliferative effects through blocking cell cycle and inducing cell apoptosis. The in vivo studies revealed that both ZV0501 and ZV0508 exhibited excellent antitumor activities even at a single dose. Although ZV0508 was inferior to ZV0501 in vitro, it elicited more durable antitumor responses than ZV0501 in vivo. The superior in vivo activity of ZV0508 may be due to the combined use of the disubstituted C-Lock linker and the novel payload Duo-5, resulting in a more stable and potent ADC. Taken together, these data suggest ZV0508 is a worthy candidate for the treatment of 5T4 positive cancers.
ChemInform Abstract: Activating Group Recycling: A Fresh Approach to Arene Functionalization (2013)

Abstract Review: ca. 50 refs.
Corrosion resistance, chemistry, and mechanical aspects of Nitinol surfaces formed in hydrogen peroxide solutions (2012)

Ti oxides formed naturally on Nitinol surfaces are only a few nanometers thick. To increase their thickness, heat treatments are explored. The resulting surfaces exhibit poor resistance to pitting corrosion. As an alternative approach to accelerate surface oxidation and grow thicker oxides, the exposure of Nitinol to strong oxidizing H(2)O(2) aqueous solutions (3 and 30%) for various periods of time was used. Using X-Ray Photoelectron Spectroscopy (XPS) and Auger spectroscopy, it was found that the surface layers with variable Ti (6-15 at %) and Ni (5-13 at %) contents and the thickness up to 100 nm without Ni-enriched interfaces could be formed. The response of the surface oxides to stress in superelastic regime of deformations depended on oxide thickness. In the corrosion studies performed in both strained and strain-free states using potentiodynamic and potentiostatic polarizations, the surfaces treated in H(2)O(2) showed no pitting in corrosive solution that was assigned to higher chemical homogeneity of the surfaces free of secondary phases and inclusions that assist better biocompatibility of Nitinol medical devices.
Antibody to a Human DNA Repair Protein Allows for Cloning of a <i>Drosophila</i> cDNA That Encodes an Apurinic Endonuclease (1989)

The cDNA of a Drosophila DNA repair gene, AP3, was cloned by screening an embryonic lambda gt11 expression library with an antibody that was originally prepared against a purified human apurinic-apyrimidinic (AP) endonuclease. The 1.2-kilobase (kb) AP3 cDNA mapped to a region on the third chromosome where a number of mutagen-sensitive alleles were located. The cDNA clone yielded an in vitro translation product of 35,000 daltons, in agreement with the predicted size of the translation product of the only open reading frame of AP3, and identical to the molecular size of an AP endonuclease activity recovered following sodium dodecyl sulfate-polyacrylamide gel electrophoresis of Drosophila extracts. The C-terminal portion of the predicted protein contained regions of presumptive DNA-binding domains, while the DNA sequence at the amino end of AP3 showed similarity to the Escherichia coli recA gene. AP3 is expressed as an abundant 1.3-kb mRNA that is detected throughout the life cycle of Drosophila melanogaster. Another 3.5-kb mRNA also hybridized to the AP3 cDNA, but this species was restricted to the early stages of development.
Spray atomization characteristics as a function of pesticide formulations and atomizer design (1994)

Abstract The use of formulation adjuvants to increase the drop size of pesticide sprays has followed a practice which has evolved through many years of experimentation and development. The earliest materials used were simply designed to make the spray mix viscous on the premise that a mayonnaise‐like fluid would produce larger drops and hence increase the deposit efficiency. These viscomer materials, emulsions and water soluble thickeners such as starch and agars, as well as more complex cellulose materials, produced thick non‐Newtonian fluids which were difficult to mix, pump and spray, and provided questionable results. First, the larger drops reduced target coverage from a given volume of spray; and second, field tests with these definitely showed that a large volume of small drops were still being produced even with the thickest of formulations. The next step in adjuvant evolution was the introduction of polyvinyl, polyacrylamide and polyamide elastomer materials. These polymers are also non‐Newtonian, but due to their peculiar molecular bonding, they have the capability of forming long string‐like streams which when atomized can retract into a spray of large drops. Pure forms of these polymers are blended by commercial producers to enable compatibility with pesticide chemicals. We have conducted a series of laboratory and wind tunnel tests; first, to try and establish some physical parameters identifying their characteristics and second, to determine how these adjuvants affect atomization and the production of small drift‐prone drops (i.e., those smaller than 120 μm in diameter). Our results with the laboratory studies of physical properties and of the wind tunnel drop size tests have been inconclusive. The elastomer materials have relatively low viscosity (1.5 to 6 mPa.s) and reduced surface tension (50 to 60 mN/m) but our stream‐flow extension tests were non‐productive. The drop size studies comparing water sprays with polymer‐water mixtures gave us a mixed picture. Generally drop size was increased for all of the fan (deflector and milled orifice) and cone type atomizers. But an increase was also indicated of the volume of spray in drops less than 120 μm showing that the polymer did not fully control the production of these small drops under all of the testing procedures we studied. It is difficult to evaluate the capability of these additives for controlling or reducing production of the drift‐prone small drops. While the pure solutions of the water soluble polymers would appear to be capable of this desirable effect, it is also evident that in order to make these formulations compatible with pesticide spray solutions, several other solvents, emulsifiers and surface active chemicals are added to the formulation, thus affecting the atomization characteristics and hence their drift‐control capability.
Target Space Modeling - The End of 3D Widgets (2010)

In today’s modeling tools, the graphical user interfaces are required to be accurate and intuitive to use. Most tools therefor rely\non additional 3D-widgets (e.g., arrows or circles) that enable the user to operate towards a desired modeling result. In this paper\nwe present, for the first time, a method that makes these widgets obsolete. We propose to use simple geometric primitives such\nas planes or spheres as low-dimensional subspaces, so called target spaces for the interaction. Instead of operating towards a\nmodeling result, the user then directly steers the result. The target spaces suffice to be indicated to the user just as additional\nvisual information. We verify by means of a user study that with our method it is now possible to develop accurate single-view\nGUIs without 3D-widgets that are highly intuitive to use.
Experimental study of stabilization of the inverted pendulum with horizontal and vertical movement via exact linearization based on the dynamic extension (2010)

This paper discuss about the problem of the stabilization of the inverted pendulum on the cart which moves not only in the horizontal direction but also in the vertical direction. This stabilizing problem is addressed by the exact linearization via dynamic extension. The conditions for the system to be the exact linearizable via dynamic extension is derived by restricting the form of the extension and the input transformation which converts the system to satisfy the conditions is derived. After applying the input transformation, the system is extended and applied a feedback transformation. Then the linear controllable system associated with the inverted pendulum system is derived. The validity of this linearization is shown by the several numerical simulations and experiments. In the experiments, the inverted pendulum system is realized by means of the 3-link manipulator.
Tensile creep failures of Al{sub 2}O{sub 3}/SiC nanocomposite (1994)

The dispersion of ceramic particles with nanometer size into the ceramic matrix grains or grain boundaries gives rise to substantial improvements of the mechanical properties, particularly at high temperatures. However, creep performance, which is one of the most important mechanical properties for high temperature engineering materials has not been investigated for the ceramic nano-composite. This paper reports tensile creep performance of alumina dispersed with 17 vol% silicon carbide nanoparticles at 1200{degrees}C. Compared to the mono-lithic alumina, the nanocomposite exhibited excellent creep resistance. The minimum creep rate of the nanocomposite was about three orders of magnitude lower and the creep life was 10 times longer than those of the monolithic. The improved creep resistance is caused by intergranular silicon carbide nanoparticles which rotate and plunge into alumina grains as grain boundary sliding proceeds.
Surface conductivity measurements on thin polymer films (1986)

A novel method of measuring the surface conductivity of thin dielectric films has been developed using a concentric cylinder arrangement. The system has been studied analytically and the result substantiated experimentally.