gebhart/patrepeval huggingface dataset:
Involvement of cyclooxygenase‐2 in the tumor site‐dependent production of parathyroid hormone‐related protein in colon 26 carcinoma (2007)

It has been shown that in the mouse colon 26 tumor model, tumors grown in the subcutis (subcutis colon 26) caused early onset of cachectic syndromes, whereas those in the liver (liver colon 26) did not. Both interleukin (IL)-6 and parathyroid hormone-related protein (PTHrP) were involved in the development of cachectic syndromes in this tumor model. However, whether expression of PTHrP and IL-6 is differently regulated in the tumor microenvironment is unclear. In the present study, culturing the colon 26 cells under different conditions in vitro revealed that IL-6 production was increased by monolayer culture under a low-glucose condition but not by spheroid culture. In contrast, PTHrP production was increased by spheroid culture but not by monolayer culture, even under a low-glucose condition. Gene expression profiling revealed that the expression of cyclooxygenase (COX)-2 was up-regulated in both subcutis colon 26 and spheroid cultures, and that COX-2 inhibitor NS-398 suppressed PTHrP production in spheroid cultures. Furthermore, administration of NS-398 decreased the PTHrP level without affecting the tumor growth in mice bearing subcutis colon 26. These results demonstrate that production of PTHrP and IL-6 largely depends on the microenvironments in which tumors are developed or metastasized and that up-regulation of COX-2 in a necrobiotic environment leads to PTHrP production, thereby causing cachectic syndromes.
Management of high-level nuclear wastes (1978)

Significant developments in the management of high-level nuclear wastes that have occurred in the last 2 years are reviewed. The principal thrust is on the policy and technical developments in the United States, but some attention is paid to major developments in other countries which have impacted technical direction in the US.
A comparison of symbolic and spatial filing (1985)

The traditional and still dominant form of object reference in computing systems is symbolic - data files, programs, etc. are initially labeled and subsequently referred to by name. This approach is being supplemented on some systems by a spatial alternative which is often driven by an office or desktop metaphor (e.g. Apple's Lisa and MacIntosh systems, or Bolt's 1979 Spatial Data Management System). In such systems, an object is placed in a simulated two- or three-dimensional space, and can later be retrieved by pointing to its location. In order to begin to understand the relative merits of spatial and symbolic filing schemes for representing and organizing information, we compared four ways of filing computer objects. We found location information to be of limited utility, either by itself or in combination with symbolic information. This calls into question the generality and efficacy of the desktop metaphor for information retrieval.
OC-053 Lectin-Based Near infra-red Molecular Imaging for Dysplasia Detection in Barrett’s Oesophagus: An ex-vivo Study on Human Tissue (2016)

<h3>Introduction</h3> Detection of early neoplasia in Barrett’s oesophagus (BO) by white-light endoscopy is challenging due to the inconspicuous nature of dysplasia. Molecular imaging using fluorescently labelled wheat-germ agglutinin (WGA) is a promising tool as this topically applied imaging agent shows lower binding to dysplastic versus non-dysplastic BO.<sup>1</sup> However in an endoscopy setting, the detection of fluorescence in the blue/green range is limited by high-levels of tissue autofluorescence. This limitation can be overcome by using near infra-red (NIR) imaging. We aimed to assess in an <i>ex-vivo</i> model the feasibility of WGA-based NIR imaging for detection of dysplasia in BO. <h3>Methods</h3> we recruited patients with early BO-related neoplasia undergoing endoscopic mucosal resection (EMR). Freshly collected EMR specimens were sprayed with WGA-IR800CW and then imaged with a high-sensitivity NIR camera. Fluorescence images were captured and up to two punch biopsies were collected from each EMR under fluorescence guidance. The EMRs were paraffin embedded, cut every 2 mm and processed for histopathological assessment. Each section was scored by an expert GI pathologist every 1 mm to construct a pathology grid, which was manually co-registered with the fluorescence image. The mean fluorescence intensity (MFI) of cells in dysplastic and non-dysplastic areas was compared by the Wilcoxon matched-pairs signed rank test. Only EMR specimens with at least one dysplastic gland were included in the analysis. In addition, the MFI of punch biopsies taken from dysplastic and non-dysplastic areas was also compared by Mann-Whitney test. <h3>Results</h3> Ten patients were recruited at a single centre. A total of 18 EMR specimens and 33 punch biopsies were collected, of which 10 were dysplastic. In the whole EMR analysis, we found a significantly lower MFI for dysplastic versus non-dysplastic areas (P = 0.0012), in accordance with the reported reduced binding of WGA to neoplastic BO epithelium. Similarly, we found a nearly 2 fold reduction in the MFI of punch biopsies taken from dysplastic as compared to non-dysplastic (ND) areas (P = 0.0002) (Figure 1). <h3>Conclusion</h3> WGA-based NIR imaging is an effective method for differentiating dysplastic from non-dysplastic BO mucosa <i>ex vivo</i>, which reduces the effects of tissue autofluorescence. <i>In-vivo</i> studies are now required to test the efficacy of this method for detecting dysplasia during endoscopic surveillance. <h3>Reference</h3> 1 Bird-Lieberman, <i>et al</i>. <i>Nat Med</i> 2012. <h3>Disclosure of Interest</h3> None Declared
Optical nonlinear correlation based on nonuniform subband decomposition (1999)

We present a nonlinear correlation to improve the selectivity for optical pattern recognition. The approach is based on morphological correlation which involves a threshold decomposition concept. Hereby, we propose a subband decomposition in the Fourier domain to perform the threshold decomposition operation. We consider two frequency bands that give rise to two separate channels. We apply the morphological correlation to each channel using a localized threshold decomposition. Then, we define a two-channel morphological correlation. The final detection decision is made as a combination of both correlation outputs. The two-channel morphological correlation yields improved discrimination capability and noise robustness compared with common linear and morphological correlation. Computer simulations are presented as well as optical experiments performed using a joint transform correlator.
STUDIES ON ISOLATED SECRETORY GRANULES FROM BOVINE NEUROHYPOPHYSES (1972)

ABSTRACT Isolated secretory granules from neural lobes of bovine hypophyses were incubated with tritiated lysine-vasopressin. Gradient centrifugation of these granules showed a difference in the distribution on the gradient of labelled vasopressin as compared with endogenous vasopressin, suggesting a heterogeneity of the granules in the homogenate. In other experiments the release from the granules to the medium of the tritiated hormone and of endogenous arginine-vasopressin was studied under various experimental conditions. Addition to the medium of calcium with or without ATP did not affect the release of hormone from the granules. ATP alone had no significant effect on the granular release of hormone. However, in the presence of an ATP-regenerating system (pyruvate kinase + phosphoenolpyruvate) ATP caused a slight, but significant increase in the release of endogenous vasopressin, whereas the release of labelled hormone was unchanged. Increasing the pH of the incubation medium caused an increased release of hormone from the granules. A similar effect was observed when the medium was cooled or when the osmolality was changed.
Three-dimensional numerical simulation of two-degree-of-freedom VIV of a circular cylinder with varying natural frequency ratios at<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si97.gif" display="inline" id="mml97" overflow="scroll"><mml:mi mathvariant="normal">Re</mml:mi><mml:mo>=</mml:mo><mml:mn>500</mml:mn></mml:math> (2017)

The two-degree-of-freedom (2DOF) vortex-induced vibration (VIV) of a circular cylinder with varying in-line to cross-flow natural frequency ratios (f* = fnx/fny) is studied using a three-dimensional (3D) computational fluid dynamics (CFD) approach. Numerical simulation is carried out for a constant mass ratio of 2 at a fixed Reynolds number Re = 500. The reduced velocity ranges from 2 to 12. Three natural frequency ratios are considered, i.e., f* = 1, 1.5 and 2. The structural damping is set to zero to maximise the response of the cylinder. The main objective of this study is to investigate the effect of f* on the 2DOF VIV responses and the 3D characteristics of the flow. It is discovered that there is a significant increase in the vibration amplitude, and the peak amplitude shifts to a higher reduced velocity when f* increases from 1 to 2. A single-peak cross-flow response is observed for the identical in-line and cross-flow mass ratios when f* = 2. Dual resonance is found to exist over the range of f* studied. The preferable trajectories of the cylinder in the lock-in range are counterclockwise figure-eight orbits. Oblique figure-eight trajectories appear at Vr = 6, 7 and 8 when f* = 1. The third harmonic component which is observed in the lift fluctuation increases with f*. The correlation decreases in the lock-in range and reaches its minimum value around the transition region between the lock-in and post-lock-in ranges. Three vortex shedding modes (2S, P + S and 2P) appear in the present simulation. A dominant P + S mode is associated with the oblique figure-eight trajectories. Variation of vortex shedding flows along the cylinder is observed leading to the poor correlation of the sectional lift forces.
Modeling the Physical Stability of a Catalyst in a Coking Enviroment (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling the Physical Stability of a Catalyst in a Coking EnviromentJoseph R. Kiovsky and George W. YoungCite this: Ind. Eng. Chem. Fundamen. 1978, 17, 4, 283–287Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/i160068a011https://doi.org/10.1021/i160068a011research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Silicon photonics and applications in aerospace (2015)

Silicon based photonic integration technology has advanced significantly in the last several years and is now being deployed commercially in data center applications. It can bring unique opportunities for avionics systems to utilize photonics.
MATERIALS SYSTEM FOR INTERMEDIATE TEMPERATURE SOLID OXIDE FUEL CELL (2004)

AC complex impedance spectroscopy studies were conducted on symmetrical cells of the type [gas, electrode/LSGM electrolyte/electrode, gas]. The electrode materials were slurry-coated on both sides of the LSGM electrolyte support. The electrodes selected for this investigation are candidate materials for SOFC electrodes. Cathode materials include La{sub 1-x}Sr{sub x}MnO{sub 3} (LSM), LSCF (La{sub 1-x}Sr{sub x}Co{sub y}Fe{sub 1-y}O{sub 3}), a two-phase particulate composite consisting of LSM + doped-lanthanum gallate (LSGM), and LSCF + LSGM. Pt metal electrodes were also used for the purpose of comparison. Anode material investigated was the Ni + GDC composite. The study revealed important details pertaining to the charge-transfer reactions that occur in such electrodes. The information obtained can be used to design electrodes for intermediate temperature SOFCs based on LSGM electrolyte.
NMR Studies of the Lanthanide(III) Complexes of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakis(methanephosphonic acid mono(2‘,2‘,2‘-trifluoroethyl) ester) (1997)

A new macrocyclic ligand 1,4,7,10,-tetraazacyclododecane-1,4,7,10-tetrakis(methanephosphonic acid mono(2‘,2‘,2‘-trifluoroethyl) ester) (F-DOTPME) has been prepared and some of its metal binding properties examined. The ligand protonation constants (log K1 = 10.5, log K2 = 6.7) and its stability constant with CaII (log KCaL = 8.4) were determined by pH potentiometry. The stability of the LaIII complex could not be determined by potentiometry so it was evaluated in an EDTA competition experiment using 31P NMR to monitor the reaction. The dissociation kinetics of La(F-DOTPME)- was slow, with a kd,obs of only 1.0 × 10-7 s-1. A series of Ln(F-DOTPME)- complexes (LnIII = La, Gd, Dy, Tm, and Yb) were examined by multinuclear NMR. The spectra show that these complexes exist in aqueous solution as a mixture of stereoisomers of nearly equal energy (energy differences of less than 1 kJ/mol). Several resolved 19F resonances in the NMR spectra of the Dy(F-DOTPME)-, Tm(F-DOTPME)-, and Yb(F-DOTPME)- complexes have been assigned to specific diastereomers by comparing resonance integrals, assuming an interaction model between neighboring pendant arms, and the magnitude and direction of the hyperfine 19F NMR shifts induced by the paramagnetic lanthanide cation. Cationic detergents added to two different Ln(F-DOTPME)- complexes altered the distribution of isomers in favor of the symmetrical Δ-SSSS isomer, while neutral polyethylene glycol affected the 19F chemical shifts of some isomers without altering their populations. Gd(F-DOTPME)- displayed a water proton relaxivity (R1) of 2.5 mM-1 s-1 at 25 °C and 40 MHz, typical of complexes lacking an inner-sphere-coordinated water molecule. 17O NMR was used to confirm that Dy(F-DOTPME)- does not have an inner-sphere-coordinated water molecule. Addition of human serum albumin to aqueous solutions of Gd(F-DOTPME)- produced a 4-fold increase in water relaxivity, and an analysis of binding curves indicated the fluorinated complex binds to HSA with a binding constant of about 0.17 mM.
Short and long‐term effects of interferon on serum markers of hepatitis C virus replication (1993)

Hepatitis C virus RNA (HCV-RNA) and serological markers of HCV infection were measured in 30 patients with chronic hepatitis C who had been treated with interferon (IFN). Patients were classified into four groups according to serum alanine aminotransferase (ALT) levels after treatment. These were: as complete responders (CR); partial responders (PR); transient responders (TR); and non-responders (NR). In all 11 patients in the CR group, HCV-RNA disappeared from serum for at least 24 months and anti-c100-3 decreased progressively during this time. In the PR group, four of five patients were positive for HCV-RNA in spite of the improvement of ALT levels and decline of anti-c100-3. In the TR and NR groups, HCV-RNA disappeared transiently or remained persistently positive. The results indicate that IFN-mediated improvement of ALT and decrease of anti-HCV (anti-c100-3) were not always related to the disappearance of HCV-RNA from serum. On the other hand, sustained disappearance of HCV-RNA from serum was demonstrated in the patients who did not have post-treatment ALT relapse. This indicates that IFN can eradicate HCV from serum in some patients and provide a clinical remission of chronic hepatitis C.
Chemical and Biological Dynamics Using Droplet-Based Microfluidics (2017)

Recent years have witnessed an increased use of droplet-based microfluidic techniques in a wide variety of chemical and biological assays. Nevertheless, obtaining dynamic data from these platforms has remained challenging, as this often requires reading the same droplets (possibly thousands of them) multiple times over a wide range of intervals (from milliseconds to hours). In this review, we introduce the elemental techniques for the formation and manipulation of microfluidic droplets, together with the most recent developments in these areas. We then discuss a wide range of analytical methods that have been successfully adapted for analyte detection in droplets. Finally, we highlight a diversity of studies where droplet-based microfluidic strategies have enabled the characterization of dynamic systems that would otherwise have remained unexplorable.
Le silence de Justine (2019)

Par une nuit de novembre 1872, sur les hauteurs de Rouen, Delphin Luce, un garcon de dix ans, et la jeune Justine Boulard sont sauvagement agresses, au retour de l'usine de tissage ou ils sont employes. L'enfant perit dans cette attaque qui bouleverse la Normandie. Lorsqu'elle recouvre la parole, Justine varie dans la description de son agresseur et la police multiplie les arrestations, aiguillonnee par la presse, les rumeurs, les denonciations. Enfin, a la surprise generale, la jeune fille designe un proche, pere de famille jouissant d'une honorable reputation. Faut-il la croire ? Confronte a la fragilite des temoignages, a l'ambiguite des faits, aux silences de Justine qui reveillent les spectres de l'occupation prussienne recente, le juge d'instruction Julien Delavigne doit eclairer de bien sombres mysteres. Avant de guider la justice vers un inattendu coupable...
Hypersonic incipient separation on delta wing with trailing-edge flap (1975)

The paper reviews the experimental data on the incipient separation characteristics of planar delta wings of 75 degree sharp leading edges, with full-span trailing edge flap deflected into the windward flow. The local Reynolds number range for these investigations covered laminar, transitional and turbulent conditions. It is shown that, while turbulent boundary layer data correlates with two dimensional results, in the laminar and transitional cases, there is a nearly parallel shift to higher flap angles for incipient separation.
Development of Standardized Clinical Assessment and Management Plans (SCAMPs) in Plastic and Reconstructive Surgery (2015)

Full execution of the SCAMP may allow better-defined selection criteria for this complex patient population. Deviations from the SCAMP may allow for improvement of the SCAMP and facilitate consensus within the Division. Iterative and adaptive quality improvement utilizing SCAMPs creates an opportunity to reduce cost by improving knowledge about best practice.
The regulation and role of catecholamines in hypertension and pheochromocytoma (1994)

There has been significant recent progress in our understanding of catecholamines, both in pheochromocytoma and in essential hypertension. In pheochromocytoma, improvements in imaging studies, such as computed tomography, magnetic resonance imaging, metaiodobenzylguanidine scanning, and positron-emission scanning, as well as biochemical methods, such as advances in measurement of catecholamines and their metabolites in urine and plasma by improved high-performance liquid chromatography techniques, have greatly facilitated detection of pheochromocytomas, especially those that present with atypical features and in extra-adrenal sites. Recent studies have also provided greater understanding of the role of the sympathetic nervous system and catecholamines in essential hypertension. Microneurographic studies, in which sympathetic nerve traffic is measured directly, as well as regional norepinephrine spillover studies, have provided additional evidence for augmented sympathetic nervous system activity in essential hypertension.
Abundant Plpp Sequence Has the Same Conformation in Unrelated Proteins (1995)

It has been shown that a low complexity sequence PLPP is abundantly present in a representative set of PIR database. The PLPP fragment has the same loop conformation in five unrelated protein structures. Conformational analysis of PXPP tetrapeptides, as well as analysis of known protein structures, shows that this particular conformation should be adopted for any X more bulky than valine.
Design of an Experimental Solar-Powered, Solid-Adsorption Ice Maker (1986)

Purely thermal heat pumps can be devised with adsorbate/solid adsorbent pairs, for example for refrigeration purposes. As each cycle consists of two periods, i.e., heating/desorption/condensation and cooling/adsorption/evaporation, this mode of operation is well-suited to solar energy. After experiments with the Zeolite/Water pair, a solar-powered ice maker was designed with the Activated Carbon/Methanol pair, and a prototype was built in Orsay. The solar collectors (6 m2) contain, on the whole, 130 kg of A.C., the condensers are air-cooled, and the evaporator has a net production of 30–35 kg of ice per sunny day. The ice is easily removed, and in principle the machine could be automatically operated. The net solar C.O.P. is 0.12, which makes this machine one of the most efficient solar ice makers.
Optical Fiber Vibration and Acceleration Model (2007)

We derive expressions for the group velocities of transverse electric and transverse magnetic electromagnetic waves in a stretched single-mode fiber. Stretching can occur either as a result of temperature changes of the spool on which the fiber is wound, or as a result of axial vibrations that accelerate and hence deform the spool. Long single-mode fibers are typically used in optoelectronic oscillators, where the group velocity plays a central role in determining the oscillator frequencies. The present idealized calculation assumes there is a fractional length change deltal/l, that results in stress in the fiber. This stress changes the optical properties of the fiber, and hence the group velocities, through its stress-optic coefficients. The principal result of the present calculation is that for optoelectronic oscillators, the main effect on the frequencies comes from the change of length itself rather than from the change in group velocities.
Overlapping phrase-level translation rules in an SMT engine (2004)

We explore a technique for adding longer phrase translation pairs to a statistical machine translation (SMT) system. Merging existing phrase-level alignments that have overlapping words on both the source and target sides generates new phrases. The effect on translation quality is reported for an Arabic-English system in the news domain.
REGULATION OF IMMUNOLOGIC REACTIVITY IN SARCOIDOSIS* (1976)

An atomistic computer simulation was performed for the polyimides ULTEM™ and EXTEM™ via the molecular-dynamics method with the use of Gromos53a6 and Amber99 force fields. For parameterization of electrostatic interactions, the partial atomic charges were calculated through quantum-chemical methods. The temperature dependence of density and the thermal-expansion coefficients for the polyimides were obtained. The calculated density values of the polyimides at room temperature and their coefficients of thermal expansion in the glassy state are in agreement with available experimental data. It is shown that inclusion of electrostatic interactions is necessary for simulation of the thermophysical characteristics of the considered polyimides.