gebhart/patrepeval huggingface dataset:
An optical 3D digitizer for frameless stereotactic surgery (1996)

This frameless system for defining the precise spatial coordinates of a site of surgical interest has many advantages over conventional frame based systems and provides accuracy comparable to commonly used units. The system uses computer hardware and software to reconstruct 2D digital images into a 3D volumetric image display. The 3D images, when combined with a spatially digitizing sensor to define a location in space, can be directly registered to anatomical structures or markers in the surgical field. The display can then be used to track the sensor position and, therefore, the surgical position, thus eliminating the guesswork of intuitively transferring radiographic information to the operative field. This system, the ISG Viewing Wand, has proved to be objective and accurate at integrating imaging data with the structures in the operative field, with a clinical accuracy of approximately 3 millimeters.
Organic photo- and electroluminescent devices with double mirrors (1993)

Luminescent spectra of organic thin films sandwiched with two mirrors were measured in an effort to detect optical microcavity effects. Narrowing and enhancement of photoluminescent spectra were observed from the tri-(8-hydroxyquinolinol)aluminum monolayer with the mirrors at both sides. Furthermore, the narrowing of spectra was also observed from electroluminescent devices fabricated with two mirrors.
(Duration Times Spread) for CDS: A New Measur e of Spread Sensitivity (2007)

We extend the study of Ben Dor, Dynkin, Hyman, Houweling, Leeuwen and Penninga [2007] on the behaviour of corporate bond spreads to the realm of credit default swaps using a new estimation technique. The quasi-maximum likelihood approach we employ can accommodate the stochastic nature of the relation between spread volatility and spread level. Consistent with the Results for corporate bonds, we find support for a linear relationship between spread volatility and spread level with some evidence of non-linear effects.
Pressure drop, penetration and quality factor of filter paper containing nanofibers (2016)

Nanofiber has shown outstanding performance in many studies. Blending nanofibers into fibrous filter media is a promising way to improve the filtration performance. This paper discussed the modeling method for multi-fiber filter paper and the proper way to apply nanofiber into filter paper. Sixteen different filter papers were prepared and these filter papers covered the range of coarse-fiber-dominant and fine-fiber-dominant fibrous structure. The theoretical modeling method in this study for pressure drop and penetration of multi-fiber filter paper showed accurate results compared with the experiment data. It was found that for the higher quality factor, the nanofibers should be effectively separated by the coarse fibers. This study presented the idea of the fiber's effective contribution to filtration efficiency, which can lead to a comprehensive and distinct understanding of fibrous structure and filtration properties.
Effects of feedyard Manure Dust on Performance and Health of Young Spanish Goats (2001)

Dust is an environmental stressor and can become extensive in confined animal feedingoperations especially during dry environmental conditions. However, there is very little data onthe effects of dust stress on animal performance and health. This study was conducted to determine the effects of simulated feedyard manure dust on the performance and fever status ofyoung Spanish goats with or without Micotil protection. Thirty six weanling female Spanishgoats (average body weight 20 kg) were randomly allotted by initial body weight into groups(replicates) of 3 and placed in pens (n = 12) where feed consumption could be measured. Sixpens of goats were randomly assigned to either a control (no dust exposure) or dust exposure.Within each dust treatment group were nested Micotil (3 groups) or no Micotil protection (3groups). All goats were fed a standard growing diet. Daily feed intake (by pen) was measuredand goats weighed individually every 7 d. The dust events were generated by enclosing goatsreceiving dust exposure in a semi-air-tight canvass tent (183 cm wide X 244 cm long X 213 cmtall) and ground cattle feedyard manure dust was blown inside the tent to create a dustsuspension. There were 22 dust events with approximately 7 d of rest following 7 consecutive dof dust exposure. Each daily dust event lasted 4 h (0080 to 1200). The control goats were kept ina similar semi-air-tight canvass tent adjacent to the treated groups, except that no dust was blowninside that tent. On each day of dust exposure, rectal temperatures were recorded at 4, 8 and 12 hpost-dust exposure. Goats protected with antibiotic received intramuscular injection of 10 mgMicotil/kg of body weight (BW). Rectal temperature (fever response) was measured at 4, 8 and12 h post-dust exposure on each day of dust exposure. The results indicated that the control goatsconsumed less (P<0.01) feed but were also less efficient (P<0.05) in feed conversion than thedust exposed group. This response was contrary to our hypothesis. However, goats protectedwith Micotil had better (P<0.05) feed to gain ratio than those not protected with antibiotic.Four and 8 h after dust exposure increased (P<0.002) fever more in the dust treated group thanthe control group increasing their chance of being considered sick. Micotil protection was moreeffective (P <0.05) only during the first 4 and 8 h after the first single dust exposure. These datasuggest the effects of manure dust on the performance of goats require additional investigation.Furthermore, antibiotic protection is effective in alleviating fever during initial dust events butnot during chronic events.
TRAFFIC-RELATED AIR POLLUTION, ASTHMA AND HAY FEVER AT THE AGE OF 11 (2011)

Background and aim: In the PIAMA-study, we found positive associations between residential exposure to traffic-related air pollution and the incidence and prevalence of asthma and asthma symptoms until age 8. Puberty is an important milestone for the development of asthma and allergy. We therefore extended our previous analyses with three years of follow-up and studied the association between residential exposure to traffic-related air pollution and asthma and hay fever at age 11 years. Methods: We estimated exposure to NO2, fine particulate matter, and soot at the birth address by land-use regression models. Associations of exposure to air pollution with questionnaire-reports of diagnoses and symptoms of asthma and hay fever and were explored by multiple logistic regression analysis in approximately 2600 children. Effects were first estimated for all children and then for boys and girls separately by adding a gender-air pollution interaction term to the model. Results: The participants’ median age was 11.3 years (range 10.1-12.8). Overall, air pollution was (marginally) significantly associated with shortness of breath [adjusted odds ratio (95% confidence interval) 1.36 (1.05-1.77) per 3.5 μg/m3 (interquartile range) change in PM2.5] and nocturnal dry cough [1.30 (0.99-1.69)]; doctor-diagnosed hay fever [1.43 (1.03-1.97)], and symptoms of allergic rhinitis [1.25 (0.96-1.63)] during the past 12 months. Associations between PM2.5 and these symptoms of asthma were largely limited to girls, while associations with hay fever were found in boys and girls. However, effects of air were not significantly different between boys and girls. Air pollution was associated with doctor-diagnosed asthma in girls [1.72 (1.00-2.96)], but not in boys [0.83 (0.50-1.35)], p-value interaction < 0.05]. Conclusions: Exposure to traffic-related air pollution is positively associated with symptoms of asthma, hay fever and related symptoms at age 11 years. The association with asthma may be stronger in girls than in boys.
Model complexes of tumor necrosis factor-α with receptors Rl and R2 (1995)

The biological activities of tumor necrosis factor-alpha (TNF-alpha) are mediated by two different receptors, TNFR1 and TNFR2. To analyze the receptor binding site(s) of TNF-alpha, molecular models have been built of the complexes of TNF-alpha with the extracellular regions of receptors R1 and R2, based on the known crystal structures of TNF-alpha and lymphotoxin bound to R1. The model structure of R2 from residues 18-160 was built by analogy to the crystal structure of R1 in complex with lymphotoxin. The amino acid sequences of R1 and R2 show 27.5% identity over this region and were aligned with five insertions and three deletions. There are 18 conserved cysteines that form disulfides. R2 has lost one pair of cysteines compared with R1, but two new cysteines were modeled as forming a new disulfide bond. Both symmetric and asymmetric trimers of TNF-alpha were used to model the complexes with TNFR1 and R2. An analysis of differences in the model complexes showed good agreement with data on the differential binding of TNF mutants to its two receptors.
Long-term follow-up after surgical treatment of isolated tricuspid valve endocarditis (2013)

Objective: Acute tricuspid valve (TV) endocarditis is associated with high morbidity and mortality, but long-term data of these patients are limited. The aim of this study was to investigate the outcome of patients that underwent surgery for isolated TV endocarditis.
Tripod facial surfactants with benzene as the central core: design, synthesis and self-assembly study (2012)

The design, synthesis and self-assembled study of a new class of benzene-derived tripod facial amphiphiles are reported. The synthetic route chosen based on a central mesitylene as scaffold allows easy tuning of lipophilic and hydrophilic groups and thus control of the tensioactive properties of these new surfactants. This new class of surfactants exhibits three glucose moieties as the hydrophilic polar head and three hydrocarbon chains each having 3 to 7 carbons as the lipophilic part. These tripod facial amphiphiles exhibit well-defined tensioactive and aggregative properties. Their critical aggregation concentration, their particle size in water (less than 20 nm), and their aggregation behavior are closely linked to the nature of their lipophilic chains and can therefore be easily modulated.
Handbook of Tunnel Engineering I: Structures and Methods (2013)

The standard reference on the theory and practice of tunnel engineering for German-speaking tunnelers is Handbuch des Tunnel- und Stollenbaus. This English edition, representing the latest knowledge in the field of tunnel engineering, is based on the third German edition. The book is published in two volumes. The first volume explores the practical aspects of tunnel construction and construction processes. Sections in the book include support methods and materials, classic methods of tunneling, shotcrete tunneling, drill and blast tunneling,mechanized tunneling, microtunneling, and ventilation. Practical examples are included in each chapter.
Precision requirements for observing macroscopic quantum effects (2013)

It has recently been conjectured that detecting quantum effects such as superposition or entanglement for macroscopic systems always requires high measurement precision. Analyzing an apparent counterexample involving macroscopic coherent states and Kerr or higher-order nonlinearities, we find that while measurements with coarse outcomes can be sufficient, the phase control precision of the necessary nonlinear operations has to increase with the size of the system. This suggests a refined conjecture that either the outcome precision or the control precision of the measurements has to increase with system size.
Adaptronische und mechatronische Systeme unter dem Aspekt der Betriebsfestigkeit (2001)

S.283-294
Synaptic and axonal remodeling of mossy fibers in the hilus and supragranular region of the dentate gyrus in kainate-treated rats (1998)

Seizures evoked by kainic acid and a variety of experimental methods induce sprouting of the mossy fiber pathway in the dentate gyrus. In this study, the morphological features and spatial distribution of sprouted mossy fiber axons in the dorsal dentate gyrus of kainate-treated rats were directly shown in granule cells filled in vitro with biocytin and in vivo with the anterograde lectin tracer Phaseolus vulgaris leucoagglutinin (PHAL). Sprouted axon collaterals of biocytin-filled granule cells projected from the hilus of the dentate gyrus into the supragranular layer in both transverse and longitudinal directions in kainate-treated rats but were not observed in normal rats. The sprouted axon collaterals projected into the supragranular region for 600-700 microm along the septotemporal axis. Collaterals from granule cells in the infrapyramidal blade crossed the hilus and sprouted into the supragranular layer of the suprapyramidal blade. Sprouted axon segments in the supragranular layer had more terminal boutons per unit length than the axon segments in the hilus of both normal and kainate-treated rats but did not form giant boutons, which are characteristic of mossy fiber axons in the hilus and CA3. Mossy fiber axons in the hilus of kainate-treated rats had more small terminal boutons, fewer giant boutons, and there was a trend toward greater axon length compared with mossy fibers in the hilus of normal rats. With the additional length of supragranular sprouted collaterals, there was an overall increase in the length of mossy fiber axons in kainate-treated rats. The synaptic and axonal remodeling of the mossy fiber pathway could alter the functional properties of hippocampal circuitry by altering synaptic connectivity in local circuits within the hilus of the dentate gyrus and by increasing the divergence of the mossy fiber terminal field along the septotemporal axis.
Inhibition of an In Vitro CD4+ T Cell Alloresponse Using Altered Peptide Ligands (1998)

In this study, we explore the potential of altered peptide ligands (APLs) to modulate the alloresponse of CD4+ T cells using elements of the murine hemoglobin (Hb) Ag model. We first demonstrated that the T cell 2.102, specific for the Hb(64-76)/I-Ek complex, was alloreactive against splenocytes of the H-2p haplotype. Using Ab-blocking and transfection experiments, we further showed that this alloreactivity was restricted to the class II molecule I-Ep. We tested a panel of APLs previously shown to antagonize the Hb response of 2.102 and found that these peptides could also effectively inhibit the alloresponse to I-Ep. Importantly, these peptides were able to antagonize the alloresponse of naive T cells derived from mice transgenic for the 2.102 TCR, as well as Th1 and Th2 cell lines. The antagonism required the presence of both I-Ep and I-Ek on the same APC. Our study demonstrates the effectiveness of APLs to antagonize the primary alloresponse of specific T cells and provides a basis for the development of immunotherapeutics for use in transplantation and immune-mediated diseases.
Microwave Discharge of O<sub>2</sub> and CO<sub>2</sub> as a Synthetic Tool for Oxidations of Unsaturated Compounds Adsorbed on Solid Supports (1983)

Abstract Cis and trans stilbene, styrene, 1‐decene and 6‐dodecene adsorbed on silica gel were reacted with oxygen atoms produced by microwave discharge of O 2 and CO 2 . At 0°C these compounds gave mainly epoxides and carbonyl compounds as in neat liquid reactions. Below — 60°C ozonolysis products were formed; cis and trans stilbene and styrene gave benzaldehyde while 1‐decene and 6‐dodecene resulted mainly in ozonides.
Cytological Studies of Large Nucleus‐Like Structures Formed by Exogenously‐Injected Linear and Circular DNAs in Fertilized Eggs of <i>Xenopus laevis</i> (1992)

Relatively large amounts of linear or circular DNAs were injected into the animal or vegetal cytoplasm of fertilized eggs of Xenopus laevis and the nature of large nucleus-like structures formed by the injected DNAs was studied cytologically and electron microscopically. Results of fluorescent microscopic examination combined with immunohistochemical analysis strongly suggested that the injected DNAs were assembled into the nucleus-like structures probably after being complexed with maternal histones. The assemblage of nucleus-like structures preferentially took place in the animal most region of the egg, and the size of the nucleus-like structures formed depended on the amount of the injected DNA. The nucleus-like structures were surrounded by double membranes equipped with nuclear pore complexes, but there were at least two abnormal features in their ultrastructures. First, nucleus-like structures contained cytoplasmic particulate materials, most probably ribosomes and/or glycogen granules. Secondly, many of the nuclear pore complexes on the "nuclear envelope" appeared to be incomplete, with blebs formed from inner leaflet and protruded into the perinuclear space. Injected circular plasmid DNAs were also assembled into large nucleus-like structures in the animal most region, and appeared to be partitioned into descendant cells during the cleavage.
Sonografie – von der Forschung zur physiotherapeutischen Praxis (2020)

Zusammenfassung Weltweit setzen Physiotherapeuten die Sonografie sowohl in der klinischen Praxis als auch zu Forschungszwecken ein. Die Autorinnen erläutern die wichtigsten Anwendungsmöglichkeiten und beschreiben drei klinische Anwendungsgebiete, bei denen sich die Untersuchung per Ultraschall in der Physiotherapie lohnen könnte.
The Virulence Plasmid of Shigellae: an Archipelago of Pathogenicity Islands? (2014)

Shigella strains are gram-negative, nonsporulating, nonencapsulated, facultative aerobic, nonmotile, straight rods that belong to the family Enterobacteriaceae and to the tribe Escherichiaeae. These observations suggest that virulence plasmids are made up of conserved building blocks and that some differences between various plasmids might be the result of shuffling of these building blocks. This chapter focuses on genes carried by the virulence plasmid that are or might be involved in the pathogenicity of Shigella. The virulence plasmid is an IncFII replicon, and functions involved in plasmid maintenance and stability have been recently described. Three genes carried by the virulence plasmid have been implicated in the ability of Shigella to move within the cytoplasm of infected cells: icsA (virG), sopA (icsP),and virK. The current model proposes that binding of H-NS to the virB promoter at low temperature prevents its activation by VirF. SepA homologs such as PssA from Shiga toxin-producing E. coli and EspP from enterohemorrhagic E. coli are also encoded by virulence plasmids and are flanked by sequences related to IS600,IS911,IS203, and IS7. Two different genes, designated apy and phoN-Sf, encoding periplasmic phosphatases about 25 kDa have been cloned from the virulence plasmid of two S. flexneri isolates of serotype 2a. So far, all the proteins identified as or proposed to be effectors of the specific interactions that occur between Shigella and host cells are encoded by the virulence plasmid.
Increased Particulate Air Pollution and Markers of Platelet Aggregation (2014)

Background: Increased particulate air pollutant concentrations (PM) have previously been associated with platelet aggregation. Aspirin has been shown to protect against cardiovascular (CV) events. We hypothesized that increased ambient PM concentrations would be associated with increased markers of platelet aggregation, and that aspirin would lessen this response. Methods: We used data from a sequential therapy trial of aspirin and fish oil (n=30 subjects; 4 blood samples; 10/2010-3/2012) in type II diabetes patients. Using linear mixed models, we estimated changes in 3 platelet measures (aggregation induced by adenosine diphospate [ADP] or collagen, and thromboxane production) associated with interquartile range (IQR) increases in 1 to 96 hour mean concentrations of ambient PM2.5, black carbon, ultrafine particle (UFP; 10-100nm), and accumulation mode particle (AMP; 100-500nm) concentrations. Results: IQR increases in mean UFP and AMP concentrations were associated with significant decreases in platelet function, with the largest being a -1.7 ohm reduction in collagen-induced aggregation (95% CI= -3.1, -0.3) associated with each 2097 particles/cm3 increase in UFP, and a -0.43 decrease in log(thromboxane; pg/mL; 95% CI=-0.8, -0.1) associated with each 582 particles/cm3 increase in AMP, both in the previous 72 hours. We found no associations with PM2.5 or black carbon. Further, this UFP effect on thromboxane was greater when taking aspirin (-0.6; 95% CI = -1.0, -0.3) then when not (-0.0; 95% CI = -0.4, 0.3; interaction p=0.003). Conclusions: Inconsistent with our a priori hypothesis, we found that decreased platelet thromboxane production and collagen-induced aggregation were associated with increased UFP and AMP levels in the previous 3-4 days, with aspirin increasing this effect. The reason for this is unclear, but may be related to the disrupted lipid milieu and aspirin insensitivity in patients with type 2 diabetes.
Techno-Economics of Distributed Generation and Storage of Solar Hydrogen (2010)

For hydrogen to become a truly sustainable energy vector, low carbon generation technologies need to be developed and brought to market.Hydrogen from solar energy is a promising approach, capable, if successfully developed, of producing hydrogen from an abundant source with greatly reduced carbon emissions.At present fundamental research on a wide range of solar hydrogen technologies is being investigated, including thermal, biological and electrochemical methods.The technoeconomic properties of these technologies differ significantly.Some are best suited to largescale centralised applications, whereas others may be employed on a smaller scale as part of a distributed energy resource strategy.
Multipartite entanglement in the optical frequency comb of a depleted-pump optical parametric oscillator (2011)

We study the effect of pump depletion in a single type-I optical parametric oscillator (OPO) and find that pump-mediated, signal-field quantum correlations generate multipartite entanglement in the optical frequency comb of the OPO.
Synthesis of 9,13b-dihydroisoindolo[2,1-d][1,4]benzodiazepin-6-one (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 9,13b-dihydroisoindolo[2,1-d][1,4]benzodiazepin-6-oneGoetz E. Hardtmann and Hans OttCite this: J. Org. Chem. 1969, 34, 8, 2244–2248Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/jo01260a002https://doi.org/10.1021/jo01260a002research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts