gebhart/patrepeval huggingface dataset:
Nucleation and propagation of solitary Schallamach waves (2015)

We isolate single Schallamach waves--detachment fronts that mediate inhomogeneous sliding between an elastomer and a hard surface--to study their creation and dynamics. Based on measurements of surface displacement using high-speed in situ imaging, we establish a Burgers vector for the waves. The crystal dislocation analogs of nucleation stress, defect pinning, and configurational force are demonstrated. It is shown that many experimentally observed features can be quantitatively described using a conventional model of a dislocation line in an elastic medium. We also highlight the evolution of nucleation features, such as surface wrinkles, with consequences for interface delamination.
P2‐460: A quantitative cellular sensor of protein aggregation (2011)

The process of protein misfolding and aggregation into insoluble deposits is associated with a wide range of human disorders known as amyloidoses that include Alzheimerś disease. The quest for molecules that can modulate the protein aggregation process has thus far been approached using in vitro aggregation assays. Successful molecules are evaluated for reduction of amyloid induced toxicity in cell culture, and the best hits are tested in animal models of the disease. So far, none of the small molecules that been identified using these in vitro assays have proceeded to clinical trials and have exhibited a therapeutic benefit. One the reasons that underlie this problem is that the methods used for evaluation of such compounds are not very representative of the in vivo situation. To date, a quantitative in vivo model of protein misfolding and aggregation is still missing. We designed a sensor of intracellular protein misfolding and aggregation, based on measuring the enzymatic activity of fusion proteins, in which intracellular or extracellular reporter enzymes are fused to amyloidogenic proteins. Aggregation of the chimeric reporter results in reduction of enzymatic activity. One main advantage of our sensor versus existing technologies is that enzymatic activity is an extremely sensitive detection method, which is suitable for HTS and can be quantified not only in cell culture but also in the whole, live animal. We find that our system is very sensitive and can, with dynamic range of two orders of magnitude, measure intra- and extra-cellular protein aggregation in human cell lines and primary neuronal cultures, as well as in the CNS of mice. It is also up to date the first quantitative cellular sensor for extracellular protein aggregation. Our data show that this system is useful to screen libraries of small molecules or genetic modifiers that can interfere, block or reverse the process of protein aggregation in mammalian neurons. This in vivo system is also able to provide exact measurements that can be used for modeling of the aggregation process in a complex cellular environment and to develop prediction algorithms based on those data.
Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity (2009)

The p53 tumor suppressor is a multifaceted transcription factor that responds to a diverse array of stresses that include DNA damage and aberrant oncogene signaling. On activation, p53 prevents the emergence of cancer cells by initiating cell cycle arrest, senescence (terminal cell cycle arrest), or apoptosis. Although its role in assuring longevity by suppressing cancer is well established, recent studies obtained largely from genetically engineered mouse models suggest that p53 may regulate longevity and aging. In some contexts, it appears that altered p53 activity may enhance longevity, and in others, it appears to suppress longevity and accelerate aging phenotypes. Here, we discuss how genetically engineered mouse models have been used to explore antiproliferative functions of p53 in cancer suppression and how mouse models with altered aging phenotypes have shed light on how p53 might influence the aging process.
Composition, Structure and Properties of Electroless Deposited Rhenium-Rich Re-Co Thin Films (2016)

Rhenium (Re) is a promising refractory metal that has unique combination of properties. Compared to other refractory metals, Re has the greatest tensile strength and excellent creep resistance over a wide range of temperatures (up to ~2000°C). Pure Re does not have a ductile-to-brittle transition temperature. Moreover, unlike other refractory metals, Re does not form stable carbides. Thus, it is potentially attractive coating on different carbon material. Electroless plating is relatively simple method for generating thin metallic and metal alloy films on conductive and nonconductive surfaces. The ability of electroless plating to coat the inside of holes and recesses without using external current source or vacuum technology equipment makes it an ideal coating technology for many applications. In this study, high Re content (more than 65 at.%) Re-Co coatings were prepared by electroless deposition. The pH dependence of process kinetics, film microstructure and composition was studied. The obtained films were characterized by HRSEM, AFM, XPS and XRD methods. It was shown that as deposited films have amorphous structures with microhardness value of 600 - 620 HV. Crystalline hcp structure of Re-Co coating was detected only after annealing at 550 o C. Thin coatings (250-500 nm) have demonstrated good corrosion protection of copper in salt medium reducing corrosion current at list by one order of magnitude. The annealed deposits have shown improved mechanical and electrical properties. Such films exhibit ferromagnetism and could be applied in mobile magnetic components where soft-magnetic response combined with mechanical stability is required (MEMS devices).
Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease (2002)

Results suggest that cortical atrophy is an index of disease severity in both AD and subcortical cerebrovascular brain injury and consequently predicts faster progression. Hippocampal volume may index disease severity and predict progression in AD. The absence of this effect in cases with lacunes suggests that this group is etiologically heterogeneous and is not composed simply of cases of AD with incidental stroke.
Chronic Kidney Disease Is Associated With the Incidence of Atrial Fibrillation (2011)

In this large population-based study, reduced kidney function and presence of albuminuria were strongly associated with the incidence of AF independently of other risk factors.
TGF‐β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment (2012)

Microglia are myeloid-derived cells that colonize the central nervous system (CNS) at early stages of development and constitute up to 20% of the glial populations throughout life. While extensive progress has been recently made in identifying the cellular origin of microglia, the mechanism whereby the cells acquire the unique ramified and quiescent phenotype within the CNS milieu remains unknown. Here, we show that upon co-culturing of either CD117(+) /Lin(-) hematopoietic progenitors or CD11c(+) bone marrow derived cells with organotypic hippocampal slices or primary glia, the cells acquire a ramified morphology concomitant with reduced levels of CD86, MHCII, and CD11c and up-regulation of the microglial cell-surface proteins CX(3) CR1 and Iba-1. We further demonstrate that the transforming growth factor beta (TGF-β) signaling pathway via SMAD2/3 phosphorylation is essential for both primary microglia and myeloid-derived cells in order to acquire their quiescent phenotype. Our study suggests that the abundant expression of TGF-β within the CNS during development and various inflammatory processes plays a key role in promoting the quiescent phenotype of microglia and may thus serve as a target for therapeutic strategies aimed at modulating the function of microglia in neurodegenerative diseases such as Alzheimer's and prion.
Chemokines and Chemokine Receptors in the Brain (1999)

Cytokines play a major role in orchestrating the response of the immune system to invasion by pathogenic organisms. In the late 1980s several cytokines were described that not only modulated the activity of immune cells but also elicited their migratory responses. These newly described cytokines, of which interleukin 8 (IL-8) was a prototypic member, delineated a new branch of cytokines called chemokines (chemo-tactic cytokines). Chemokines are small mainly basic proteins that have been classified into four distinct families, CXC, CC, C, and CX3C, based on the position of their con-served cysteine residues. The two major branches are the CXC and CC chemokines. CXC chemokines include IL-8 and melanoma growth stimulatory activity (MGSA) and are mainly involved in acute inflammation, inducing the migration of neutrophils. The CC chemokines include RANTES, MCP-1 and MIP-1α and are primarily involved in chronic inflammation chemoattracting monocytes and T cells.
Study of Conformational States of ABC exporters by Computer Modeling and Molecular Dynamics Simulations (2008)

info:eu-repo/semantics/nonPublished
Thymic Stromal Lymphopoietin Is Produced by Dendritic Cells (2011)

Thymic stromal lymphopoietin (TSLP) is a type 1 cytokine that contributes to lymphopoiesis and the development of asthma and atopic dermatitis. TSLP acts on multiple lineages, including dendritic cells (DCs), T cells, NKT cells, eosinophils, and mast cells, mediating proliferation and survival and linking innate and adaptive immune responses. TSLP is produced by a range of cells, including epithelial cells, fibroblasts, stromal cells, and keratinocytes. DCs are important primary targets of TSLP, and we unexpectedly demonstrated that DCs also produce TSLP in response to TLR stimulation and that this is augmented by IL-4. Moreover, we demonstrated that when mice were challenged with house dust mite extract, lung CD11c(+) DCs expressed TSLP mRNA at an even higher level than did epithelial cells. These data suggested that DCs not only respond to TSLP but also are a source of TSLP during pathogen and/or allergen encounter.
OLDER AGE AND TIME TO LAST BIOPSY ARE ASSOCIATED WITH RISE IN GLEASON SCORE FOR MEN ON ACTIVE SURVEILLANCE FOR LOW RISK PROSTATE CANCER (2008)

You have accessJournal of Urology1 Apr 2008OLDER AGE AND TIME TO LAST BIOPSY ARE ASSOCIATED WITH RISE IN GLEASON SCORE FOR MEN ON ACTIVE SURVEILLANCE FOR LOW RISK PROSTATE CANCER Marc A Dall'Era, Badrinath R Konety, Maxwell V Meng, Katsuto Shinohara, Nannette Perez, Janet E Cowan, and Peter R Carroll Marc A Dall'EraMarc A Dall'Era More articles by this author , Badrinath R KonetyBadrinath R Konety More articles by this author , Maxwell V MengMaxwell V Meng More articles by this author , Katsuto ShinoharaKatsuto Shinohara More articles by this author , Nannette PerezNannette Perez More articles by this author , Janet E CowanJanet E Cowan More articles by this author , and Peter R CarrollPeter R Carroll More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60441-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "OLDER AGE AND TIME TO LAST BIOPSY ARE ASSOCIATED WITH RISE IN GLEASON SCORE FOR MEN ON ACTIVE SURVEILLANCE FOR LOW RISK PROSTATE CANCER." The Journal of Urology, 179(4S), p. 154 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 154 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Marc A Dall'Era More articles by this author Badrinath R Konety More articles by this author Maxwell V Meng More articles by this author Katsuto Shinohara More articles by this author Nannette Perez More articles by this author Janet E Cowan More articles by this author Peter R Carroll More articles by this author Expand All Advertisement PDF downloadLoading ...
Anatomical-Based FDG-PET Reconstruction for the Detection of Hypo-Metabolic Regions in Epilepsy (2004)

Positron emission tomography (PET) of the cerebral glucose metabolism has shown to be useful in the presurgical evaluation of patients with epilepsy. Between seizures, PET images using fluorodeoxyglucose (FDG) show a decreased glucose metabolism in areas of the gray matter (GM) tissue that are associated with the epileptogenic region. However, detection of subtle hypo-metabolic regions is limited by noise in the projection data and the relatively small thickness of the GM tissue compared to the spatial resolution of the PET system. Therefore, we present an iterative maximum-a-posteriori based reconstruction algorithm, dedicated to the detection of hypo-metabolic regions in FDG-PET images of the brain of epilepsy patients. Anatomical information, derived from magnetic resonance imaging data, and pathophysiological knowledge was included in the reconstruction algorithm. Two Monte Carlo based brain software phantom experiments were used to examine the performance of the algorithm. In the first experiment, we used perfect, and in the second, imperfect anatomical knowledge during the reconstruction process. In both experiments, we measured signal-to-noise ratio (SNR), root mean squared (rms) bias and rms standard deviation. For both experiments, bias was reduced at matched noise levels, when compared to post-smoothed maximum-likelihood expectation-maximization (ML-EM) and maximum a posteriori reconstruction without anatomical priors. The SNR was similar to that of ML-EM with optimal post-smoothing, although the parameters of the prior distributions were not optimized. We can conclude that the use of anatomical information combined with prior information about the underlying pathology is very promising for the detection of subtle hypo-metabolic regions in the brain of patients with epilepsy.
Melioidosis in New Caledonia: a dominant strain in a transmission hotspot (2015)

Melioidosis is an infectious disease caused by Burkholderia pseudomallei, a bacterium endemic in Southeast Asia and northern Australia. In New Caledonia, sporadic cases were first described in 2005; since then, more cases have been identified. To improve our understanding of melioidosis epidemiology in New Caledonia, we compared the local cases and B. pseudomallei isolates with those from endemic areas. Nineteen melioidosis cases have been diagnosed in New Caledonia since 1999, mostly severe and with frequent bacteraemia, leading to three (16%) fatalities. All but one occurred in the North Province. Besides sporadic cases caused by non-clonal strains, we also identified a hotspot of transmission related to a clonal group of B. pseudomallei that is phylogenetically related to Australian strains.
Enantioselective Cyclopropanation with TADDOL‐Derived Phosphate Ligands. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Normal Proteolytic Processing of the Presenilins (2003)

The majority of familial Alzheimer's disease (AD) cases are linked to mutations of the presenilin 1 and 2 (PS1, PS2) genes on chromosomes 14 and 1, respectively (1-3). PS1 and PS2 are about 67% identical in amino acid sequence. Based on hydrophobicity analysis, the presenilins are predicted to have multiple transmembrane domains. Structural analysis (see Chapter 19 }) suggest that presenilins are 6-8 transmembrane proteins which are located in the endoplasmic reticulum (ER) and Golgi. The N- and C-termini and the large hydrophilic loop region are oriented to the cytoplasm (4,5). More than 40 AD-causing mutations have been identified in PS1, whereas only two mutations have been identified in PS2. The disease-causing mutations span most domains of the protein, with clusters of mutations in the second transmembrane domain and the large hydrophilic loop region Fig. 1).
A HEAT TREATMENT THERMAL INACTIVATION METHOD FOR LYOPHYLIZED IV GAMMAGLOBULIN TO REDUCE RISK OF VIRAL TRANSMISSION (1990)

Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.
<title>1024x1024 resistive emitter array design and fabrication status</title> (2002)

Santa Barbara Infrared (SBIR) is producing a high performance 1,024 x 1,024 Large Format Resistive emitter Array (LFRA) for use in the next generation of IR Scene Projectors (IRSPs). LFRA requirements were developed through close cooperation with the Tri-Service IR Scene Projector working group, and through detailed trade studies sponsored by the OSD Central T&E Investment Program (CTEIP) and a Phase I US Navy Small Business Innovative Research (SBIR) contract. The CMOS Read-In Integrated Circuit (RIIC) is being designed by SBIR and Indigo Systems under a Small Business Innovative Research (SBIR) contract. Performance and features include 750 K MWIR maximum apparent temperature, 5 ms radiance rise time, 200 Hz full frame update, and 400 Hz window mode operation. Ten 8-inch CMOS wafers will be fabricated and characterized in mid-2002, followed by emitter fabrication in late 2002. This paper discusses array performance, requirements flow-down, array design, fabrication of 2 X 2-inch CMOS devices, and plans for subsequent RIIC wafer test and emitter pixel fabrication.
Entanglement test in micro-macroscopic photon system: criteria and assumptions (2011)

In this work we discuss the topic of observing the micro‐macro entanglement in the specific system presented in a recent work [F. De Martini et al., Phys. Rev. Lett. 100, 253601 (2008)]. There the overall micro‐macro state was obtained by an amplification process performed over an entangled couple. Here we discuss the assumptions underling the performed experimental test and we address the feasibility of a “genuine” entanglement test based on deliberate attenuation of the macro state.
Polycyclic Compounds. II. Reactions of the Mannich Base of Levulinic Acid (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolycyclic Compounds. II. Reactions of the Mannich Base of Levulinic AcidR. M. Dodson and Paul SollmanCite this: J. Am. Chem. Soc. 1951, 73, 9, 4197–4199Publication Date (Print):September 1, 1951Publication History Published online1 May 2002Published inissue 1 September 1951https://pubs.acs.org/doi/10.1021/ja01153a046https://doi.org/10.1021/ja01153a046research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fundamental electronic structure and multiatomic bonding in 13 biocompatible high-entropy alloys (2020)

Abstract High-entropy alloys (HEAs) have attracted great attention due to their many unique properties and potential applications. The nature of interatomic interactions in this unique class of complex multicomponent alloys is not fully developed or understood. We report a theoretical modeling technique to enable in-depth analysis of their electronic structures and interatomic bonding, and predict HEA properties based on the use of the quantum mechanical metrics, the total bond order density (TBOD) and the partial bond order density (PBOD). Application to 13 biocompatible multicomponent HEAs yields many new and insightful results, including the inadequacy of using the valence electron count, quantification of large lattice distortion, validation of mechanical properties with experiment data, modeling porosity to reduce Young’s modulus. This work outlines a road map for the rational design of HEAs for biomedical applications.
Flattening Earth acceleration in atomic fountains (2010)

A method to compensate for Earth's gravity tide over an extended axial region is reported. Flattening acceleration is important in experiments where the coupling of the dynamics of free-falling probes to the gravity gradient generates stochastic noise on the measurement. Optimized cylindrically symmetric mass distributions lower Earth's tidal effect over $10$ cm by a factor $10$${}^{3}$. A multimass compensation system with comparable performance is devised for tall atom interferometers. Reducing the gravity gradient is essential in terrestrial experiments based on atom fountain configurations being developed to precisely test general relativity or the neutrality of matter.
The Chemistry of Neutron Capture Therapy. (<i>Chem. Rev.</i> <b>1998</b>, <i>98</i>, 1515. Published on the Web May 20, 1998) (1998)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionThe Chemistry of Neutron Capture Therapy. (Chem. Rev.1998, 98, 1515. Published on the Web May 20, 1998)Albert H. Soloway, Werner Tjarks, Beverly A. Barnum, Feng-Guang Rong, Rolf F. Barth, Iwona M. Codogni, and J. Gerald WilsonCite this: Chem. Rev. 1998, 98, 6, 2389–2390Publication Date (Web):September 24, 1998Publication History Published online24 September 1998Published inissue 24 September 1998https://pubs.acs.org/doi/10.1021/cr980493ehttps://doi.org/10.1021/cr980493ecorrectionACS PublicationsCopyright © 1998 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1679Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (16 KB) Get e-Alertsclose Get e-Alerts