gebhart/patrepeval huggingface dataset:
Formulation and evaluation of new triangular, quadrilateral, pentagonal and hexagonal discrete Kirchhoff plate/shell elements (2001)

Abstract The paper deals with the formulation of plate and shell elements based on the discrete Kirchhoff technique. In the first part we review the flat facet shell elements which have been formulated during the last 30 years. In the second part, we present the formulation of a new family of discrete Kirchhoff plate/shell elements based on the free formulation. The triangular, quadrilateral, pentagonal andhexagonal elements belong also to the family of semi‐Loof elements having only displacements at the corner nodes and one tangential rotation along each side. Copyright © 2001 John Wiley & Sons, Ltd.
Supporting the Design of Machine Learning Workflows with a Recommendation System (2016)

Machine learning and data analytics tasks in practice require several consecutive processing steps. RapidMiner is a widely used software tool for the development and execution of such analytics workflows. Unlike many other algorithm toolkits, it comprises a visual editor that allows the user to design processes on a conceptual level. This conceptual and visual approach helps the user to abstract from the technical details during the development phase and to retain a focus on the core modeling task. The large set of preimplemented data analysis and machine learning operations available in the tool, as well as their logical dependencies, can, however, be overwhelming in particular for novice users. In this work, we present an add-on to the RapidMiner framework that supports the user during the modeling phase by recommending additional operations to insert into the currently developed machine learning workflow. First, we propose different recommendation techniques and evaluate them in an offline setting using a pool of several thousand existing workflows. Second, we present the results of a laboratory study, which show that our tool helps users to significantly increase the efficiency of the modeling process. Finally, we report on analyses using data that were collected during the real-world deployment of the plug-in component and compare the results of the live deployment of the tool with the results obtained through an offline analysis and a replay simulation.
Distinct circular dichroism spectroscopic signatures of polyproline II and unordered secondary structures: Applications in secondary structure analyses (2014)

Circular dichroism (CD) spectroscopy is a valuable method for defining canonical secondary structure contents of proteins based on empirically-defined spectroscopic signatures derived from proteins with known three-dimensional structures. Many proteins identified as being "Intrinsically Disordered Proteins" have a significant amount of their structure that is neither sheet, helix, nor turn; this type of structure is often classified by CD as "other", "random coil", "unordered", or "disordered". However the "other" category can also include polyproline II (PPII)-type structures, whose spectral properties have not been well-distinguished from those of unordered structures. In this study, synchrotron radiation circular dichroism spectroscopy was used to investigate the spectral properties of collagen and polyproline, which both contain PPII-type structures. Their native spectra were compared as representatives of PPII structures. In addition, their spectra before and after treatment with various conditions to produce unfolded or denatured structures were also compared, with the aim of defining the differences between CD spectra of PPII and disordered structures. We conclude that the spectral features of collagen are more appropriate than those of polyproline for use as the representative spectrum for PPII structures present in typical amino acid-containing proteins, and that the single most characteristic spectroscopic feature distinguishing a PPII structure from a disordered structure is the presence of a positive peak around 220nm in the former but not in the latter. These spectra are now available for inclusion in new reference data sets used for CD analyses of the secondary structures of soluble proteins.
Flexible field emitter made of carbon nanotubes microwave welded onto polymer substrates (2007)

The drastic temperature rise of multiwall carbon nanotubes (MWCNTs) in response to microwave irradiation was applied to weld a MWCNT paste on a polymer substrate within a few seconds. It provides a strong bonding between the MWCNT and polymer without thermal damage to the substrate. A flexible field emitter was made from MWCNT microwave welded on polycarbonate, showing excellent electrical conduction and field-emission properties even under bending. The field emitter works with a turn-on voltage of 0.8V∕μm due to the direct electron transfer. By this method, printed circuits and field-emission devices can be processed simultaneously within seconds leading to important applications in flexible electronic devices.
Contributions et applications des modeles deformables en vision par ordinateur (1994)

The nature of the mechanisms underlying observed sex differences in human behaviour continues to be debated. This review concentrates on the thesis that genes on the sex chromosomes other than those directly controlling sex determination, and whose functions are, at least in part, independent from hormonal influences, play a significant role in determining gender differences in behaviour. To provide an adequate basis for examining this issue, the current understanding of the nature of sex determination, differences in behaviour and the influences of sex hormones are evaluated. The possible contribution to behavioural differences of those X-linked genes which escape inactivation, or which may be subjected to imprinting, is discussed. The review concludes with a summary of the genetic basis for two sexually disparate types of behaviour.
Architecture exploration and performance analysis of a hardware backprojector at transaction level (2010)

Katsevich proposed the first theoretically exact reconstruction formula for the spiral cone-beam CT. In this paper, the transaction level modeling of the architecture of a hardware backprojector is proposed using SystemC. Accompanied with this, architecture exploration and performance analysis are performed on the timing model. Finally, with certain case studies, we come to a conclusion that nearly 3 times of speedup can be achieved by doubling the size of the on-chip memory.
China: disidencia y ciberespacio (2010)

This study examined the ownership, financing, and management strategies of the 10 largest for-profit nursing home chains in the United States, including the four largest chains purchased by private equity corporations. Descriptive data were collected from Internet searches, company reports, and other sources for the decade 1998-2008. Since 1998, the largest chains have made many changes in their ownership and structure, and some have converted from publicly traded companies to private ownership. This study shows the increasing complexity of corporate nursing home ownership and the lack of public information about ownership and financial status. The chains have used strategies to maximize shareholder and investor value that include increasing Medicare revenues, occupancy rates, and company diversification, establishing multiple layers of corporate ownership, developing real estate investment trusts, and creating limited liability companies. These strategies enhance shareholder and investor profits, reduce corporate taxes, and reduce liability risk. There is a need for greater transparency in ownership and financial reporting and for more government oversight of the largest for-profit chains, including those owned by private equity companies.
Crop Field Reflectance Measurements (2008)

We present in this paper the results of reflectance measurements performed with a three‐band passive radiometer with independent channels for solar irradiance reference. The comparative operation of the traditional method that alternatively uses measurements of the field (downward‐looking) and a white panel for reference (downard‐looking) and the new approach that involves duplicated spectral channels, each one with its own difuser that point upwards to the zenith direction (upward‐looking) is analyzed. The results indicated that the latter method is more suitable for use with passive sensors under rapid changing atmospheric conditions (such as clouds, dust, mist, smog and other scatterers), since a more reliable synchronic record of reference and incident light is achieved. Besides, having separate channels for the reference and the signal allow a better balancing of gains in the amplifiers for each spectral channel. We show the results obtained in the determination of the Normalized Difference Vegetation Index (NDVI) corresponding to 2006 and 2007 field experiments concerning weeds detection and fertilizer levels assessing in wheat, to refine sensor‐based fertilizer nitrogen rate recommendations. It is also shown the variation of the radiometric normalization measurements taken at noon (nadir solar position) for the whole culture cycle corresponding to two seasons (winter and spring).
Transparent Luminescent Films by Solution Spraying (1961)

Spraying solutions of zinc chloride or cadmium iodide with activator onto preheated Pyrex or silica glass yields cathodoluminescent films by direct reaction with the glass. The activated silicate films have excellent adherence, good transparency, and, on silica, a brightness comparable to that of evaporated films on Vycor. Films on silica require refiring in air.
Identification of Nucleolin as New ErbB Receptors- Interacting Protein (2008)

The oncogenic potential of ErbB depends on receptor levels and activation. Our results suggest that nucleolin may affect ErbB dimerization and activation leading to enhanced cell growth.
Advances in bronchoscopy for lung cancer (2012)

Bronchoscopic techniques have seen significant advances in the last decade. The development and refinement of different types of endobronchial ultrasound and navigation systems have led to improved diagnostic yield and lung cancer staging capabilities. The complication rate of these minimally invasive procedures is extremely low as compared to traditional transthoracic needle biopsy and surgical sampling. These advances augment the safe array of methods utilized in the work up and management algorithms of lung cancer.
Functional and Patient‐Reported Outcomes in Symptomatic Lumbar Spinal Stenosis Following Percutaneous Decompression (2012)

This study demonstrated significant functional improvement as well as decreased disability secondary to neurogenic claudication after mild procedure. Safety, cost-effectiveness, and quality-of-life outcomes are best compared with comprehensive medical management in a randomized controlled fashion and, where ethical, to open lumbar decompression surgery.
ADSORPTION BY ACTIVATED SUGAR CHARCOAL. I<sup>1</sup> (1922)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTADSORPTION BY ACTIVATED SUGAR CHARCOAL. I1F. E. Bartell and E. J. MillerCite this: J. Am. Chem. Soc. 1922, 44, 9, 1866–1880Publication Date (Print):September 1, 1922Publication History Published online1 May 2002Published inissue 1 September 1922https://pubs.acs.org/doi/10.1021/ja01430a004https://doi.org/10.1021/ja01430a004research-articleACS PublicationsRequest reuse permissionsArticle Views179Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RTSAT-- An Optimal and Efficient Approach to the Task Allocation Problem in Distributed Architectures (2006)

We present an advanced SAT-based approach to the task and message allocation problem of distributed real-time systems. In contrast to the heuristic approaches usually applied to this problem, our approach is guaranteed to find an optimal allocation for realistic task systems running on complex target architectures. Our method is based on the transformation of such scheduling problems into nonlinear integer optimization problems. The core of the numerical optimization procedure we use to discharge those problems is a solver for arbitrary Boolean combinations of integer constraints. While the determination of the task and message placement is done within the satisfiability checking based solver, checking for feasibility w.r.t real-time requirements is performed in a specialized real-time engine under control of the satisfiability solver. Optimal solutions are obtained by imposing a binary search scheme on top of that solver. Experiments show the applicability of our approach to industrial-size task systems
A comprehensive review on remote sensing image registration (2021)

Over the last two decades, there has been a significant improvement in the quality and volume of the remote-sensing images. With the extensive availability of the images, these are used in many applications such as change detection, image mosaicing, and image fusion where image registration is very necessary. However, image registration is a challenging task in remote sensing due to the following reasons: geometric differences between images, intensity differences, and noise affect. Over the years, wide variety of algorithms have come into existence to handle these issues. In this paper, a comprehensive review is presented on these remote sensing image registration methods. At first, the general information of remote sensing image registration, its classifications, and application areas are provided. Then, an exhaustive review is given on the existing methods and their merits as well as shortcomings are mentioned. Finally, a comparative analysis is provided for the state-of-the-art methods and current challenges of this research are presented.
Differential effects of cyclic and static stretch on coronary microvascular endothelial cell receptors and vasculogenic/angiogenic responses (2008)

Mechanical stretch, an important growth stimulus, results not only from pulsatile blood flow and diastolic stretch of the ventricles [cyclic stretch (CS)] but also from tissue expansion during growth [constant static stretch (SS)]. We compared growth factor receptor expression and vasculogenic/angiogenic responses of rat coronary microvascular endothelial cells (ECs) by exposing cells to CS (10% elongation at 30 cycles/min) and SS (constant 10% elongation). Both CS and SS increased VEGF receptor (VEGF-R)2 protein levels and the extent of tube formation and branching. Moreover, both CS and SS enhanced VEGF-induced cell proliferation and tube formation, indicating that both types of stretch increase the sensitivity of ECs to VEGF. Blockade of VEGF-R2 prevented the increases in EC proliferation and aggregate tube length. However, CS but not SS enhanced EC Tie-2 protein and migration. CS affected a greater increase in tube length and branch formation than did SS. A unique finding was that SS but not CS increased VEGFR-1 in ECs. Our study is the first to distinguish between the effects of CS and SS on growth factor receptor expression and rat coronary microvascular EC proliferation, migration, and tube formation. In conclusion, EC angiogenic responses to these two types of stretch display both differences and similarities, but both CS and SS are dependent on VEGF-R2 signaling for their vasculogenic/angiogenic effects.
Histone acetyltransferases: challenges in targeting bi-substrate enzymes (2016)

Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging from cancer and inflammatory diseases to neurological disorders, both through acetylations of histone proteins and non-histone proteins. Several HAT inhibitors, like bi-substrate inhibitors, natural product derivatives, small molecules, and protein-protein interaction inhibitors, have been developed. Despite their potential, a large gap remains between the biological activity of inhibitors in in vitro studies and their potential use as therapeutic agents. To bridge this gap, new potent HAT inhibitors with improved properties need to be developed. However, several challenges have been encountered in the investigation of HATs and HAT inhibitors that hinder the development of new HAT inhibitors. HATs have been shown to function in complexes consisting of many proteins. These complexes play a role in the activity and target specificity of HATs, which limits the translation of in vitro to in vivo experiments. The current HAT inhibitors suffer from undesired properties like anti-oxidant activity, reactivity, instability, low potency, or lack of selectivity between HAT subtypes and other enzymes. A characteristic feature of HATs is that they are bi-substrate enzymes that catalyze reactions between two substrates: the cofactor acetyl coenzyme A (Ac-CoA) and a lysine-containing substrate. This has important-but frequently overlooked-consequences for the determination of the inhibitory potency of small molecule HAT inhibitors and the reproducibility of enzyme inhibition experiments. We envision that a careful characterization of molecular aspects of HATs and HAT inhibitors, such as the HAT catalytic mechanism and the enzyme kinetics of small molecule HAT inhibitors, will greatly improve the development of potent and selective HAT inhibitors and provide validated starting points for further development towards therapeutic agents.
Performance comparison between TCP slow-start and a new adaptive rate-based congestion avoidance scheme (2002)

There have recently been simulation studies of the dynamic behavior of the TCP Slow-Start (TCP-SS) congestion control mechanism, S. Schenker et al. (1990) and L. Zhang et al. (1991), that show problems of oscillatory behavior in packet delay, congestion windows and throughput. The scheme also suffers from rapid fluctuations in queue length, periodic packet losses, and underutilization of the transmission line in a large pipeline size and/or two-way traffic environments. Fairness problems in TCP-SS are also known to occur. Based on the principles of rate control and preventive congestion mechanism, the present authors have developed a new Adaptive Rate-Based (ARB) congestion avoidance scheme that avoids these problems present in TCP-SS. Through simulations, they demonstrate, that ARB outperforms TCP-SS in two important areas: network efficiency and fairness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modern Electroforming Solutions and Their Applications (1962)

The criteria for the choice of an electrolyte for producing electroforms are: (1) physical, mechanical, and chemical properties required for each specific application, (2) permissible rate of deposition, (3) stability of the electrolyte and ease of management and control, and (4) costs in comparison with conventional fabrication methods. Properties of the deposits for various applications dictate the type of metal or alloy selected, the specific electrolyte to be employed, and the operating conditions of the bath. Significant physical, mechanical, and chemical properties of the resulting electroform which must be considered are: 1. Hardness—for wear and erosion resistance. 2. Internal stress—high internal stress, either tensile or compressive, may cause cracking, distortion, spontaneous wrinkling, or peeling from the matrix or mandrel. 3. Ductility—a brittle electroform is useless. 4. Electrical conductivity—an important factor in certain electroforms used in electronics and space vehicle components. 5. Thermal conductivity—especially important in producing plastic molds when rapid heating and cooling cycles are employed. 6. Corrosion resistance to environment—chemicals, heat, moisture. 7. Coefficient of friction—important where the electroform is used as a moving part against other surfaces. 8. Performance at extremely high or low temperatures. Some of the properties listed above do not have any significance for certain applications but usually several must fall within a predetermined range.
Dynamic signature hashing (2003)

A dynamic hashing scheme that guarantees single access retrieval from the disk is proposed. This is based on the external hashing scheme proposed by G.H. Gonnet and P.A. Larson (see JACM, vol.35, no.1, p.161-84, 1988). The performance of the scheme is achieved at the cost of a small amount of internal memory which remains proportional to the file size. The necessary algorithms for address computation, insertions and file expansions are presented. Since theoretical analysis appears too difficult, the performance is studied using simulations with real-life files.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bordetella Adenylate Cyclase Toxin Promotes Calcium Entry into Both CD11b+ and CD11b− Cells through cAMP-dependent L-type-like Calcium Channels (2009)

Adenylate cyclase toxin (ACT), a 200 kDa protein, is an essential virulence factor for Bordetella pertussis, the bacterium that causes whooping cough. ACT is a member of the pore-forming RTX (repeats-in-toxin) family of proteins that share a characteristic calcium-binding motif of Gly- and Asp-rich nonapeptide repeats and a marked cytolytic or cytotoxic activity. In addition, ACT exhibits a distinctive feature: it has an N-terminal calmodulin-dependent adenylate cyclase domain. Translocation of this domain into the host cytoplasm results in uncontrolled production of cAMP, and it has classically been assumed that this surge in cAMP is the basis for the toxin-mediated killing. Several members of the RTX family of toxins, including ACT, have been shown to induce intracellular calcium increases, through different mechanisms. We show here that ACT stimulates a raft-mediated calcium influx, through its cAMP production activity, that activates PKA, which in turn activates calcium channels with L-type properties. This process is shown to occur both in CD11b(+) and CD11b(-) cells, suggesting a common mechanism, independent of the toxin receptor. We also show that this ACT-induced calcium influx does not correlate with the toxin-induced cytotoxicity.