gebhart/patrepeval huggingface dataset:
80 Gbit/s wavelength conversion using semiconductor optical amplifier and optical bandpass filter (2005)

A wavelength converter is presented that is made out of a semiconductor optical amplifier and an optical bandpass filter. Error-free inverted wavelength conversion is demonstrated at a bitrate of 80 Gbit/s. This approach can be exploited at higher bitrates. A clear open eye indicating error-free wavelength conversion at 160 Gbit/s is also presented. This wavelength converter has a simple configuration and allows photonic integration.
Diversity and Population Dynamics of Methanogenic Bacteria in a Granular Consortium (1991)

Upflow anaerobic sludge blanket bioreactor granules were used as an experimental model microbial consortium to study the dynamics and distribution of methanogens. Immunologic methods revealed a considerable diversity of methanogens that was greater in mesophilic granules than in the same granules 4 months after a temperature shift from 38 to 55 degrees C. During this period, the sizes of the methanogenic subpopulations changed with distinctive profiles after the initial reduction caused by the shift. Methanogens antigenically related to Methanobrevibacter smithii PS and ALI, Methanobacterium hungatei JF1, and Methanosarcina thermophila TM1 increased rapidly, reached a short plateau, and then fell to lower concentrations that persisted for the duration of the experiment. A methanogen related to Methanogenium cariaci JR1 followed a similar profile at the beginning, but it soon diminished below detection levels. Methanothrix rods weakly related to the strain Opfikon increased rapidly, reaching a high-level, long-lasting plateau. Two methanogens related to Methanobrevibacter arboriphilus AZ and Methanobacterium thermoautotrophicum DeltaH emerged from very low levels before the temperature shift and multiplied to attain their highest numbers 4 months after the shift. Histochemistry and immunohistochemistry revealed thick layers, globular clusters, and lawns of variable density which were distinctive of the methanogens related to M. thermoautotrophicum DeltaH, M. thermophila TM1, and M. arboriphilus AZ and M. soehngenii Opfikon, respectively, in thin sections of granules grown at 55 degrees C for 4 months. Mesophilic granules showed a different pattern of methanogenic subpopulations.
Changes in the activity of the enzymes involved in sialic acid metabolism in isolated rat colonic mucosal cells on administration of azoxymethane (1983)

Conference Article| December 01 1983 Changes in the activity of the enzymes involved in sialic acid metabolism in isolated rat colonic mucosal cells on administration of azoxymethane ANTHONY P. CORFIELD; ANTHONY P. CORFIELD *Department of Medicine Laboratories, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOHN B. RAINEY; JOHN B. RAINEY †Department of Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOHN R. CLAMP; JOHN R. CLAMP *Department of Medicine Laboratories, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Search for other works by this author on: This Site PubMed Google Scholar SUSAN A. WAGNER SUSAN A. WAGNER Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1983 Biochemical Society1983 Biochem Soc Trans (1983) 11 (6): 766–767. https://doi.org/10.1042/bst0110766 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation ANTHONY P. CORFIELD, JOHN B. RAINEY, JOHN R. CLAMP, SUSAN A. WAGNER; Changes in the activity of the enzymes involved in sialic acid metabolism in isolated rat colonic mucosal cells on administration of azoxymethane. Biochem Soc Trans 1 December 1983; 11 (6): 766–767. doi: https://doi.org/10.1042/bst0110766 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1983 Biochemical Society1983 Article PDF first page preview Close Modal You do not currently have access to this content.
Absence of Pancreatic Intraepithelial Neoplasia (PanIN) Predicts Poor Survival Following Resection of Pancreatic Cancer: Presidential Poster (2012)

Purpose: Epithelial dysplasia in small caliber pancreatic ducts, classified as pancreatic intraepithelial neoplasia (PanIN), can be found either as an isolated finding or associated with pancreatic adenocarcinoma (PC). Graded 1-3 based on degree of atypia, PanIN lesions are commonly found in PC, yet it is not known whether the presence of PanIN has prognostic significance on survival following tumor resection. Methods: In this retrospective cohort study, we identified patients who underwent resection for PC at a single institution between 2005 and 2010. Pathology reports were reviewed for the highest grade PanIN found. In cases where PanIN was not commented upon in the initial pathology report, the case was reviewed by an experienced gastroenterology pathologist to confirm absence of PanIN. The endpoint of the study was survival following surgical resection. Baseline demographics, TNM stage, and tumor characteristics were extracted from the medical record. Kaplan-Meier survival curves and Cox Proportional Hazards Modeling was used to compare groups and predict survival. Results: We identified 289 patients with an average age at the time of surgery of 67 years (range 44-91). The majority of cases were TNM stage II disease (85%). No PanIN was demonstrated in 8% of cases. PanIN 1 was the highest degree of PanIN seen in 12% of cases, PanIN 2 in 13% of cases, and PanIN 3 in 67% of cases. Age did not significantly differ across groups (p=0.72). Kaplan-Meier curves stratified by PanIN grade demonstrated poor survival in the non-PanIN group compared to the other groups (p=0.03). Median survival in the non-PanIN group was 13 months compared to 31 months for the PanIN 1 group, 24 months for the PanIN 2 group, and 22 months for the PanIN 3 group. In univariate analysis, the hazard ratio (HR) for death for the PanIN 1 group compared to the no PanIN group was 0.42 (p=0.01). In multivariable analysis, controlling for PC stage and patient age, the HR for death for the PanIN 1 group compared to the non-PanIN group was 0.34 (p<0.01). The HR for PanIN 2 was 0.50 (p=0.03), and for PanIN 3, it was 0.55 (p=0.02), again controlled for stage and age. Treatment with adjuvant or neoadjuvant chemotherapy, tumor differentiation and other invasion characteristics did not impact survival, controlling for PanIN group, tumor stage, and patient age. Conclusion: We demonstrate here that pancreatic adenocarcinoma without PanIN lesions are associated with poor survival, controlling for stage of disease and age of patient. This may suggest tumors without PanIN are more aggressive and may be biologically distinct from those developing through the PanIN neoplastic progression route. More research is needed to better understand pancreatic carcinogenesis.
Conserved sequence pattern in a wide variety of phosphoesterases (1994)

A unique sequence pattern, designated the GD/GNH signature, was shown to be conserved in a wide variety of phosphoesterases. The enzymes containing this signature cleave phosphoester bonds in such different substrates as (1) phosphoserine and phosphothreonine in polypeptides; (2) bis(5'-nucleosidyl)-tetraphosphates; (3) nucleoside 5' phosphates; (4) 2',3'-cyclic nucleotide phosphates; (5) polynucleotides; (6) 2'-5' phosphodiesters in RNA (intron) lariats; (7) sphingomyelin; and (7) various phosphomonoesters. Two conserved acidic amino acid residues and a conserved histidine residue may be directly involved in phosphoester bond cleavage.
Clinical Article Revision of vagal nerve stimulator electrodes: technical approach (2004)

Summary Background. As the number of implanted vagal nerve stimulators grows, the need for removal or revision of the devices will become more frequent. Our purpose was to demonstrate the feasibility of complete removal of the vagal nerve stimulator electrode using microsurgical technique. Methods. Operative databases at the University of Utah (1995 through 2002), Westchester Medical Center (1995 through 2001), and University of Arizona Health Sciences Center (1995 through 1999) were retrospectively reviewed. Patients who had undergone removal or revision of a previously placed vagal nerve stimulator electrode were identified. Patients who had a vagal nerve stimulator device removed but had the lead trimmed and incompletely removed were excluded. Findings. Seven patients underwent complete removal of the lead. Microsurgical dissection allowed removal of the helical electrode from the vagus nerve without apparent physiological consequences. Four patients had a new electrode placed just proximal to the original lead site. The operative procedure required an additional 30 minutes to complete compared with initial device placement. The four patients who underwent replacement of the electrode demonstrated normal device function and lead resistance at the time of postoperative follow-up. Each experienced a return to prior stimulation response and seizure control. Conclusions. This series suggests that the electrode can be removed from the vagus nerve and repositioned without significant consequence in most cases.
Scanning electron microscope fine tuning using four-bar piezoelectric actuated mechanism (2018)

Abstract Scanning Electron Microscopes are extensively used for accurate micro/nano images exploring. Several strategies have been proposed to fine tune those microscopes in the past few years. This work presents a new fine tuning strategy of a scanning electron microscope sample table using four bar piezoelectric actuated mechanisms. The introduced paper presents an algorithm to find all possible inverse kinematics solutions of the proposed mechanism. In addition, another algorithm is presented to search for the optimal inverse kinematic solution. Both algorithms are used simultaneously by means of a simulation study to fine tune a scanning electron microscope sample table through a pre-specified circular or linear path of motion. Results of the study shows that, proposed algorithms were able to minimize the power required to drive the piezoelectric actuated mechanism by a ratio of 97.5% for all simulated paths of motion when compared to general non-optimized solution.
Expression of Concern: Accurate Analytical Spiral Inductor Modeling Techniques for Efficient Design Space Exploration (2006)

Efficient modeling techniques are required to accelerate design space exploration for integrated spiral inductors. In this letter, closed-form modeling techniques for the inductor's physical inductance and substrate eddy currents are introduced. The model provides several orders of magnitude performance improvement over field-solver-based approaches with typical errors of less than 4% while demonstrating excellent agreement with measured data from fabricated inductors
<title>State of the art in laser ultrasonic sensors using nonlinear optics</title> (1999)

Laser-based ultrasonic systems for non destructive testing and evaluation rely on the coherent detection of phase modulation imprinted on the beam by the vibrating surface. As this detection principle requires an exact superposition of the wave issued from the target with a plane reference wave, these devices only operate with a plane wave signal beam. This constraint strongly limits the spread of laser ultrasonic systems in industry. We will show how the use of dynamic holographic materials allows to implement adaptive interferometers with a large light gathering power. Two different systems that have recently led to industrial developments, will be presented and compared. Requirements for the dynamic material to be used will be discussed. Performances for ultrasound detection will be finally given.© (1999) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Paraquat: A Model for Measuring Exposure (1985)

Residues on gloves and plastic boots were used as surrogates to measure herbicide transfer from treated plants. No human exposure occurred since harvesters wore protective clothing. The model was paraquat (1,1′-dimethy1-4,4′-bipyridinium ion) residues on Cannabis sativa (marihuana). The use of paraquat on Cannabis to reduce marihuana production presents a unique model situation when the grower attempts to salvage the treated plant. Marihuana plants were grown in a greenhouse, moved to a field and ground-sprayed with a solution of paraquat (0.6 kg/ha) plus 100 uCi (methyl 14C) paraquat. Leaves of sprayed plants were harvested at 0, 1, 2, 4, 8 and 29 h after spraying. Time 0 was 10 min after spraying. Leather gloves, worn over rubber gloves, and boots were analyzed for residues. The highest residues were measured at time 0 (0.95 mg right glove, 0.50 mg left glove) and declined rapidly during the first 4 h after spraying. Residues on boot covers were lower than glove residues and also exhibited a rapid decline with time of picking. The mean plant paraquat residue, measured by combustion analysis, based on leaves harvested at time 0, was 4.65 mg per 10.41 g dry matter per plant and remained fairly constant during the first 8 h, but showed a loss of 64% (based on 14C) at 29 h.
Immunoelectron Microscopic Localization of Vivax Malaria Antigens to the Clefts and Caveola-Vesicle Complexes of Infected Erythrocytes (1988)

Erythrocytes infected with Plasmodium vivax show unique ultrastructural changes which include membranous structures in the host cell cytosol, called clefts, and caveola-vesicle complexes (CVC) in the infected erythrocyte membrane. It has been suggested that the latter structures correspond with the Schuffner's dots observed on Giemsastained thin films. The subcellular localization of a 28 kDa and a 95 kDa antigen of the erythrocytic stages of P. vivax was determined by post-embedding immunoelectron microscopy. Four monoclonal antibodies (MAbs) (2H12.B4,2H8.E10, 1H4.B6, and 4C12.G4) against the 95 kDa protein reacted with the vesicles of CVC and vesicles scattered in the cytoplasm of the infected erythrocytes. Two other MAbs (4C12.B10 and 4D7.B1) against a 28 kDa protein reacted with the cytoplasmic clefts and were also reactive with the vesicles and electron dense materials in parasitophorous vacuole. These parasite-induced structures make a contribution to the movement of some malaria proteins from the parasite to the erythrocyte surface.
Restoration of cyclophosphamide-induced suppression of thymus-derived cytotoxic cell generation by normal thymocytes. (1979)

Spleen cells from mice treated with cyclophosphamide (100 to 200 mg/kg) were unable to generate effective cytotoxic thymus-derived cells to allogeneic tumor cells in vitro. The inability of lymphoid cells from cyclophosphamide-treated mice to generate thymus-derived cytotoxic cells became more apparent as the number of responding cells became limited. This depressed response was not due to the elimination of cytotoxic precursor cells since normal response levels were restored by the addition of thymus cells. The added thymus cells did not provide cytotoxic cells in the culture. The thymus cells active in restoring cytotoxic activity were sensitive to mitomycin C, cyclophosphamide, and anti-theta serum and complement. In addition, the active thymus cells were located in the cortisone-resistant pool and did not adhere to nylon wool columns.
Nonconventional Carbon Additions to Azomethines. Aryl Amination/Indoline Synthesis by Direct Aryl Radical Addition to Azomethine Nitrogen (2001)

[reaction: see text]. The generality of a new method for aryl amination has been defined. Ketimines derived from o-bromophenethylamine cyclize to the N-substituted indoline when treated with nBu3SnH and a radical initiator. The pH-neutral conditions tolerate base- and acid-sensitive functionality. The observed regioselectivity is nonconventional for addition reactions involving carbon radicals and carbon-heteroatom pi-bonds.
Fiber Structure Development in High-Speed Melt Spinning of Polyethylene terephthalate-co-ethylene 2,6-naphthalene dicarboxylate) (1999)

Article Fiber Structure Development in High-Speed Melt Spinning of Polyethylene terephthalate-co-ethylene 2,6-naphthalene dicarboxylate) was published on October 1, 1999 in the journal Journal of Polymer Engineering (volume 19, issue 6).
Adsorption and Heat of Wetting Studies of Teflon (1956)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTAdsorption and Heat of Wetting Studies of TeflonJ. H. Chessick, F. H. Healey, and A. C. ZettlemoyerCite this: J. Phys. Chem. 1956, 60, 10, 1345–1347Publication Date (Print):October 1, 1956Publication History Published online1 May 2002Published inissue 1 October 1956https://doi.org/10.1021/j150544a001RIGHTS & PERMISSIONSArticle Views470Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (371 KB) Get e-Alerts
The use of human CD68 transcriptional regulatory sequences to direct high‐level expression of class A scavenger receptor in macrophages <i>in vitro</i> and <i>in vivo</i> (2001)

Macrophages (Mphi) play a key role in innate and acquired immunity. The study of Mphi biology has been hampered by the absence of suitable gene regulatory sequences for the overexpression of heterologous genes in Mphi. The human CD68 gene encodes a glycoprotein that is expressed in monocytes and Mphi, and therefore represents an attractive candidate gene for the generation of a Mphi-specific gene-targeting vector. A transgene expression cassette that combines 2.9 kb of CD68 5' flanking sequence with the 83-bp first intron (IVS-1) of the CD68 gene, directed high-level, long-lasting expression of class A human scavenger receptor (hSR-A) isoforms in the murine Mphi cell line, RAW-264. By using this CD68 expression cassette to generate Mphi cell lines that overexpress a soluble secreted form of the extracellular portion of type I human SR-A, we were able to purify significant quantities of this protein and show its ability to inhibit SR-A-mediated endocytosis. Analysis of two independent lines of transgenic mice that expressed type III human SR-A under the control of the CD68 gene sequences revealed transgene mRNA expression in elicited Mphi populations and in mouse tissues in a pattern that was consistent with Mphi-specific gene targeting. These data show that CD68 transcriptional regulatory sequences can be used to direct high-level transgene expression in Mphi in vitro and in vivo.
The ocular hypotensive effect of epinephrine in high and low corticosteroid responders. (1977)

Nonglaucomatous individuals were classified by their intraocular pressure response to 6 weeks of topical dexamethasone, 0.1%, four times daily. Twenty GG responders (over 31 mm. Hg after dexamethasone) and 20 NN responders (below 20 mm. Hg after dexamethasone) of similar age, sex, race, initial intraocular pressure, and facility of outflow were selected. After 24 hr. of treatment (two doses) with 1% epinephrine HCl, the GG subjects demonstrated a mean (+/-sigma) corrected decrease in intraocular pressure of 4.2 mm. Hg (+/- 2.5) as opposed to 1.8 mm. Hg (+/- 2.1) in the NN subjects (p less than 0.005). The relationship between increased responsiveness to corticosteroids, to epinephrine, and to theophylline suggested cyclic nucleotides as a possible common pathway.
Growth Factor Independence-1 Is Expressed in Primary Human Neuroendocrine Lung Carcinomas and Mediates the Differentiation of Murine Pulmonary Neuroendocrine Cells (2004)

Human small cell lung cancers might be derived from pulmonary cells with a neuroendocrine phenotype. They are driven to proliferate by autocrine and paracrine neuropeptide growth factor stimulation. The molecular basis of the neuroendocrine phenotype of lung carcinomas is relatively unknown. The Achaete-Scute Homologue-1 (ASH1) transcription factor is critically required for the formation of pulmonary neuroendocrine cells and is a marker for human small cell lung cancers. The Drosophila orthologues of ASH1 (Achaete and Scute) and the growth factor independence-1 (GFI1) oncoprotein (Senseless) genetically interact to inhibit Notch signaling and specify fly sensory organ development. Here, we show that GFI1, as with ASH1, is expressed in neuroendocrine lung cancer cell lines and that GFI1 in lung cancer cell lines functions as a DNA-binding transcriptional repressor protein. Forced expression of GFI1 potentiates tumor formation of small-cell lung carcinoma cells. In primary human lung cancer specimens, GFI1 expression strongly correlates with expression of ASH1, the neuroendocrine growth factor gastrin-releasing peptide, and neuroendocrine markers synaptophysin and chromogranin A (P < 0.0000001). GFI1 colocalizes with chromogranin A and calcitonin-gene-related peptide in embryonic and adult murine pulmonary neuroendocrine cells. In addition, mice with a mutation in GFI1 display abnormal development of pulmonary neuroendocrine cells, indicating that GFI1 is important for neuroendocrine differentiation.
Subsolidus phase relation in the BiO1.5-SrO-CaO-CuO system in air. (1988)

We have studied the subsolidus phase relation in the BiO1.5-SrO-CaO-CuO system in air. The compounds were identified by X-ray and electron diffractions. New compounds, Bi7Sr7Cu6Ox, Bi7Sr8Cu5Oy, Bi4Sr8Cu5Oz, Bi0.46CaO0.54-xSrxOy (0.1<x<0.2), Bi3Sr4Ca3Oσ and Bi0.25Sr0.75-xCax, Oy (0≤x<0.2) were found in the system.
Rigaudière (Albert). Saint-Flour, ville d'Auvergne au Bas Moyen-Âge. Étude d'histoire administrative et financière (1985)

Fournier Gabriel. Rigaudiere (Albert). Saint-Flour, ville d'Auvergne au Bas Moyen-Âge. Etude d'histoire administrative et financiere. In: Revue belge de philologie et d'histoire, tome 63, fasc. 2, 1985. Histoire medievale, moderne et contemporaine — Middeleeuwse, moderne en hedendaagse geschiedenis. pp. 386-391.