gebhart/patrepeval huggingface dataset:
Improved therapeutic index of cis-diammine dichloro platinum by diethyldithiocarbamate in rodents. (1983)

cis-Diammine Dichloro Platinum (DDP) is an effective antitumor agent. However, nephrotoxicity remains a major dose limiting factor in its clinical application. The present experiments with Fischer 344 rats showed that diethyldithiocarbamate, an alkyl dithiocarbamate, prevents DDP induced acute nephrotoxicity, and increases the LD50 from 8.3 to 10.8 mg/kg. The subacute DDP toxicity was also prevented by the DTC in B6D2F1/J mice. Further, studies with L1210 Leukemic mice indicate that DTC in dosages up to 250 mg/kg did not interfere with the antitumor effects of DDP. The present experiments, therefore, add evidence to the thesis that thiol compounds may "selectively" protect normal tissues against agents which form interstrand or intrastrand cross links with DNA. Thiol compounds, therefore, may have a wider clinical application in patients receiving cancer chemotherapy.
Obtaining carbon nanotubes from grass (2005)

Multi-walled carbon nanotubes (MCNTs) can be obtained by heating grass in the presence of a suitable amount of oxygen. Grass contains a large amount of vascular bundles in the stem and nervation. The major compositions of them are cellulose, hemicellulose and lignin. In the present approach, a rapid heat treatment (at about 600 °C) and the participation of oxygen make the vascular bundles become dehydrated and turn into carbon nanotubes. The diameters of the carbon nanotubes obtained are between 30 and 50 nm.
Technology for high-performance <i>n</i>-channel SiGe modulation-doped field-effect transistors (1995)

A fabrication process for n-channel SiGe modulation-doped field-effect transistors has been developed in which the strain in the heterostructure is completely preserved by taking into account an appropriate temperature range for the formation of ohmic contacts to source drain by implantation. It yields a low specific contact resistance of 7.1×10−5 Ω cm2 to be compared to 5.7×10−2 Ω cm2 for alloyed Au/Sb contacts. With the same thermal upper limit the application of different gate oxides has been studied. All oxides show negligible gate leakage enabling a superior gate voltage swing compared to devices with a Schottky gate. Application of thermal oxide grown at 650 °C yields a superior field-effector transistor performance compared to devices with sputter and plasma-enhanced chemical-vapor deposition deposited oxides due to its lower and negative charge level. Gate recessing of 0.5 μm Schottky gates yields a transconductance increase up to 310 mS/mm.
UDP‐Glucose level as a limiting factor for IAA‐induced cell elongation in <i>Avena</i> coleoptile segments (1987)

The effects of galactose on IAA‐induced elongation and endogenous level of UDP‐glucose (UDPG) in oat ( Avena sativa L. cv. Victory) coleoptile segments were examined under various growth conditions to see if there was a correlation between the level of UDPG and auxin‐induced growth. The following results were obtained: Galactose (10 m M ) inhibited the auxin‐induced cell elongation of oat coleoptile segments after a lag of ca 2 h. Determinations of cell wall polysaccharides and UDP‐sugars indicated that galactose, when inhibiting the cell wall polysaccharide synthesis, decreased the level of UDPG but caused an increase in the levels of Gal‐1‐P and UDP‐Gal. When coleoptile segments treated with IAA and galactose were transferred to galactose‐free IAA‐solution, the segment elongation was restored and the amounts of cell wall polysaccharides increased. During this period, the amount of UDPG increased and the levels of Gal‐1‐P and UDP‐Gal slightly decreased or leveled off. The UDP‐pentoses changed similarly as UDPG did. Addition of sucrose (30 m M ) enhanced IAA‐induced cell elongation and removed growth inhibition by 1 m M galactose. Sucrose increased the amounts of the cell wall polysaccharides and the level of UDPG in the presence or absence of IAA and also counteracted the decrease in UDPG caused by galactose. These results indicate that the level of UDPG is an important limiting factor for cell wall biosynthesis and, thus, for auxin‐induced elongation.
Reflections on nursing as a career choice (1998)

Health care management must recognize issues of concern to nurses and develop policies which make nurses feel valued.
A proposed hybrid storage assignment framework: a case study (2015)

Purpose – A hybrid storage assignment (combination class-volume-based) framework considering quality proximity, customer and material categorization are key distinguished contents of this paper. In spite of using individual storage allocation approach, the hybrid allocation policy performs better under certain environment. The paper aims to discuss these issues. Design/methodology/approach – Although it has been proved that every storage assignment policy has their advantages and limitations, one or more storage assignment policies with combination of zoning and layout design can be used together for further improvement. The authors have conducted this study at warehouse of a manufacturing firm that produce only single product with varieties of material and quality criteria. Picking optimization includes elimination of non-value-added activities like unwanted forklift and package movements, time and distance traveled for retrieval as well as storage. Other allied operations with respect to customer acceptance level and resource utilization are also considered. Findings – The time and distance from manufacturing point to storage location are accountable as it also contributes to picking performance. Originality/value – Quality-based cluster analysis is carried out to find out closeness among customers, which is used to propose algorithm with new layout design, zoning and storage allocation policy.
Ni(II)·Xaa-Xaa-His Induced DNA Cleavage:  Deoxyribose Modification by a Common “Activated” Intermediate Derived from KHSO<sub>5</sub>, MMPP, or H<sub>2</sub>O<sub>2</sub> (1998)

Ni(II) chelated peptides of the form NH2-Xaa-Xaa-His-CONH2 (Ni(II)·Xaa-Xaa-His) mediate deoxyribose damage through C4'−H abstraction of a targeted nucleotide when activated with KHSO5 (oxone), MMPP (magnesium monoperoxyphthalate), or H2O2. The products released and identified in comparison to the authentic C4'−H oxidant Fe(II)·bleomycin included fragmented DNA terminating in 5'-phosphates, 3'-phosphates, and 3'-phosphoglycolates; upon treatment of Ni(II)·Xaa-Xaa-His cleavage reactions with NaOH or NH2NH2, fragmented DNA 3'-termini were released consistent with the intermediate formation of keto-aldehyde abasic (alkaline-labile) sites. In addition, nucleobases and nucleobase propenals were detected in proportions consistent with abasic site and 3'-phosphoglycolate termini formation, respectively. These results indicate that Ni(II)·Xaa-Xaa-His metallopeptides, like Fe(II)·bleomycin, degrade DNA through two pathways resulting from an initial C4'−H modification. Importantly, the partitioning between these two pathways appears to be dependent on the structure of the Ni(II)·Xaa-Xaa-His metallopeptide employed in the cleavage reaction and the nucleotide sequence targeted. Further studies also indicate that metallopeptide activation with KHSO5, MMPP, or H2O2 yields identical reaction products and sequence-selective DNA cleavage suggesting the formation of a common "activated" metallopeptide responsible for C4'−H deoxyribose damage, quite possibly a metal-bound hydroxyl radical. These studies also demonstrate that metallopeptide activation with KHSO5 is condition-dependent resulting in (1) C4'−H damage in common with MMPP or H2O2 under relatively "low" ionic strength conditions (10 mM Na-cacodylate, pH 7.5, equimolar KHSO5/metallopeptide) or (2) guanine nucleobase oxidation under higher ionic strength conditions (100 mM NaCl, 10 mM phosphate, pH 7.0, excess KHSO5).
Unsaturated Cyclic Sulfones. III. Some Halogen-Containing Derivatives (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsaturated Cyclic Sulfones. III. Some Halogen-Containing DerivativesROBERT C. KRUG, GEORGE R. TICHELAAR, and FRANCOIS E. DIDOTCite this: J. Org. Chem. 1958, 23, 2, 212–215Publication Date (Print):February 1, 1958Publication History Published online1 May 2002Published inissue 1 February 1958https://pubs.acs.org/doi/10.1021/jo01096a016https://doi.org/10.1021/jo01096a016research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cloud Removal From Multitemporal Satellite Images Using Information Cloning (2012)

A cloud removal approach based on information cloning is introduced. The approach removes cloud-contaminated portions of a satellite image and then reconstructs the information of missing data utilizing temporal correlation of multitemporal images. The basic idea is to clone information from cloud-free patches to their corresponding cloud-contaminated patches under the assumption that land covers change insignificantly over a short period of time. The patch-based information reconstruction is mathematically formulated as a Poisson equation and solved using a global optimization process. Thus, the proposed approach can potentially yield better results in terms of radiometric accuracy and consistency compared with related approaches. Some experimental analyses on sequences of images acquired by the Landsat-7 Enhanced Thematic Mapper Plus sensor are conducted. The experimental results show that the proposed approach can process large clouds in a heterogeneous landscape, which is difficult for cloud removal approaches. In addition, quantitative and qualitative analyses on simulated data with different cloud contamination conditions are conducted using quality index and visual inspection, respectively, to evaluate the performance of the proposed approach.
Phosphotungstic Acid Catalyzed Amidation of Alcohols (2008)

Abstract Mild nucleophilic substitution reactions of benzhydrylic, benzylic, allylic, and simple aliphatic alcohols with sulfonamides, benzamide, and 4‐nitroaniline in the presence of 12‐phosphotungstic acid as an efficient, eco‐friendly, cheap, and air‐ and moisture‐tolerant catalyst for the construction of C–N bonds has been investigated. The amine derivatives were obtained in good yields (up to 98 %). The reusable nature of the 12‐phosphotungstic acid makes this protocol more attractive.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Metabolism of resorcinylic compounds by bacteria. Purification and properties of acetylpyruvate hydrolase from Pseudomonas putida 01. (1975)

Acetylpyruvate hydrolase, the terminal inducible enzyme of the pathway of orcinol catabolism in Pseudomonas putida, catalyzes the quantitative conversion of acetylpyruvate into acetate and pyruvate. The enzyme has been purified approximately 40-fold from extracts of Ps. putida grown on orcinol. Disc gel electrophoresis of the preparations show one major and one minor band of protein. The molecular weight of the enzyme is approximately 38,000 by sodium dodecyl sulfate electrophoresis. Acetylpyruvate is the only known substrate for the enzyme; maleylpyruvate, fumarylpyruvate, acetoacetate, oxalacetate, and acetylacetone are not hydrolyzed by acetylpyruvate hydrolase. Several divalent cations, includ-Mg2+, Mn2+, Co2+, Ca2+, and Zn2+, enhanced hydrolytic activity, but Cu2+ was inhibitory. The enzyme shows a sharp pH optimum at 7.4. Acetylpyruvate hydrolase has an apparent K-m of 0.1 mM for acetylpyruvate with a molecular activity of 36 min minus 1 at 25 degrees. Pyruvate, oxalacetate, and oxalate are competitive inhibitors of acetylpyruvate hydrolysis by the enzyme with K-i values of 6.0, 4.5, and 0.45 mM, respectively.
Expression of the two isoforms of spinach ribulose 1,5-bisphosphate carboxylase activase and essentiality of the conserved lysine in the consensus nucleotide-binding domain (1991)

The two isoforms of ribulose 1,2-bisphosphate carboxylase activase (Rbu-P2 carboxylase) from spinach (Spinacea oleracea L.) were individually purified from Escherichia coli transformed with expression vectors for the appropriate cDNAs. Both isoforms catalyzed activation of Rbu-P2 carboxylase (ribulose 1,5-bisphosphate carboxylase/oxygenase, EC 4.1.1.39) and ATP hydrolysis. The kinetics of the two isoforms with respect to ATP concentration were different, in that the 45-kDa polypeptide exhibited a sigmoidal response while a rectangular response was observed with the 41-kDa isoform. These observations suggest that the additional domain at the C terminus of the 45-kDa isoform modulates the ATP regulation of activity. Lysine 169, at the putative ATP-binding site of the 41-kDa form of Rbu-P2 carboxylase activase, was changed to arginine, isoleucine, and threonine by directed mutagenesis. These mutations abolished Rbu-P2 carboxylase activase and ATPase activities, as well as the capability of the protein to bind ATP. These results confirm that lysine 169 is an essential residue.
A simple high efficient torque control for the electric vehicle induction machine drives without a shaft encoder (2002)

A new torque control scheme without a shaft encoder is proposed. The scheme is based on considering the effect of temperature on rotor and stator resistances in the conventional induction machine equivalent circuit. Although the model is appropriate for both the steady state and transient conditions, the steady state behavior of the induction machine is analyzed in this paper. The induction machine is tested over more than two thousand operating points. The tests are carried out with a variable voltage and variable frequency voltage source in both motor and generator regions. Parameter values of the proposed model are identified and the model is used to estimate speed of the induction machine from its body temperature, input power, and input current. The required voltage and frequency to obtain maximum efficiency in a particular speed and command torque is calculated using the new model. This had been done for the whole torque and speed plane and the results are accumulated in a look up table. Under all circumstances, the induction machine temperature is taken into consideration. High efficiency and speed sensorless operation are two main advantageous of the proposed control technique.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Role for ELOVL4 in the Mouse Meibomian Gland and Sebocyte Cell Biology (2014)

Stgd3 mice show changes that resemble clinical findings in patients with the evaporative type of dry eye disease, suggesting that further studies in this mouse model will provide a basis for better understanding of the causes of human dry eye.
A Rule-Based Object-Oriented OWL Reasoner (2008)

In this paper, we describe O-DEVICE, a memory-based knowledge-based system for reasoning and querying OWL ontologies by implementing RDF/OWL entailments in the form of production rules in order to apply the formal semantics of the language. Our approach is based on a transformation procedure of OWL ontologies into an object-oriented schema and the application of inference production rules over the generated objects in order to implement the various semantics of OWL. In order to enhance the performance of the system, we introduce a dynamic approach of generating production rules for ABOX reasoning and an incremental approach of loading ontologies. O-DEVICE is built over the CLIPS production rule system, using the object-oriented language COOL to model and handle ontology concepts and RDF resources. One of the contributions of our work is that we enable a well-known and efficient production rule system to handle OWL ontologies. We argue that although native OWL rule reasoners may process ontology information faster, they lack some of the key features that rule systems offer, such as the efficient manipulation of the information through complex rule programs. We present a comparison of our system with other OWL reasoners, showing that O-DEVICE can constitute a practical rule environment for ontology manipulation.
Feature - Multidimensional systems and signal processing: Good theory for good practice (2007)

The subject of multidimensional systems, as originally conceived, is concerned with a mathematical framework for tackling a broad range of paradigms whose analysis or synthesis require the use of functions and polynomials in either several complex or real variables. Its applications, which may range from the processing of spatial and temporal signals of diverse physical origin to the design of linear continuous-discrete multidimensional control systems, are already plentiful. This paper aims to promote interaction between a broad spectrum of scientists and engineers through clear exposition and interpretation of fundamentals, albeit a daunting task, so that complex theoretical results become useful to practitioners in distinct but related disciplines. The expanding arena of theory and applications of the original aims and scopes attest to the importance and vitality of the subject-matter.
Area Segmentation of Images Using Edge Points (1980)

A new method for segmenting images using abrupt changes in intensity (edge points) to separate regions of smoothly varying intensity is discussed. Region segmentation using edge points has not been very successful in the past because small gaps would allow merging of dissimilar regions. The present method uses an expansion-contraction technique in which the edge regions are first expanded to close gaps and then contracted after the separate uniform regions have been identified. In order to preserve small uniform regions, the process is performed iteratively from small to large expansions with no expansion for edge regions that separate different uniform regions. The final result is a set of uniform intensity regions (usually less than 100) and a set of edge boundary regions. The program has successfully segmented scenes with industrial parts, landscapes, and integrated circuit chips.
Carbon nanotubes filled with ferromagnetic alloy nanowires: Lightweight and wide-band microwave absorber (2008)

Thin-walled carbon nanotubes (CNTs) filled with different ferromagnetic alloy (FeCo, FeNi, and FeCoNi) nanowires were prepared by using trichlorobenzene as carbon precursor. They were dispersed into epoxy resin and then coated onto 180×180 mm2 aluminum substrates to form microwave-absorption coatings with 2.0 mm thickness. Reﬂection loss exceeding −5 dB was obtained between 5 and 18 GHz for coating containing 1.3 wt % FeCo-filled CNTs. A minimum reﬂection loss value of −28.2 dB was achieved at 15.2 GHz in FeCoNi-filled CNTs/epoxy coating. The areal densities of coatings are only 2.35 kg/m2, which is favorable for the applications requiring low density.
IRENE: Context aware mood sharing for social network (2011)

Social networking sites like Facebook, twitter, and myspace are becoming overwhelmingly powerful media in today's world. Facebook has 500 million active users and twitter has 190 million visitors per month and increasing each second. On the other hand number of smart phone users has crossed 45 millions. Now we are focusing on building an application that will connect these two revolutionary spheres of modern science that has huge potential in different sectors. IRENE a facial expression based mood detection model has been developed by capturing images while the users use webcam supported laptops or mobile phones. This image will be analyzed to classify one of several moods. This mood information will be shared in the user profile of Facebook according to privacy settings of the user. Several activities and events will also be generated based on the identified mood.
Polarization converters based on axially symmetric twisted nematic liquid crystal (2010)

An axially symmetric twisted nematic liquid crystal (ASTNLC) device, based on axially symmetric photoalignment, was demonstrated. Such an ASTNLC device can convert axial (azimuthal) to azimuthal (axial) polarization. The optical properties of the ASTNLC device are analyzed and found to agree with simulation results. The ASTNLC device with a specific device can be adopted as an arbitrary axial symmetric polarization converter or waveplate for axially, azimuthally or vertically polarized light. A design for converting linear polarized light to axially symmetric circular polarized light is also demonstrated.
Modeling and performance analysis of two phase service systems (1991)

Abstract A Markovian queuing system is used to model a Two Phase Service (TPS) system. In this system, there are two queues, batch queue and individual queue, and a central server switching service between them. Expressions of mean task response time in the TPS are derived from the Markov‐Chain concept and the Z‐transform technique. Other performance parameters, such as the concept of power and speedup, and the optimization issues have also been taken into consideration. The relation between the TPS system and the other queuing system is compared and described. Furthermore, the performance improvement issue is investigated and the speedup upper bound is obtained. Finally, numerical results are provided to verify the analytical model.
Impact and preventability of adverse events in Spanish public hospitals: results of the Spanish National Study of Adverse Events (ENEAS) (2009)

To determine the impact and preventability of adverse events (AEs) associated with health care in Spanish hospitals. Retrospective cohort study. Twenty-four Spanish hospitals. Patients of any age with a clinical record indicating an inpatient stay of >24 h and a discharge between 4 and 10 June 2005 (n = 5908). None. Percentage of AEs considered preventable. We were able to identify 525 patients suffering AEs associated directly with medical care, who accumulated 655 AEs with 43% of these AEs considered preventable. Overall, 45% (295 AEs) were considered minor, 39% (255 AEs) moderate and 16% (105 AEs) severe. There were no significant differences in AE severity by hospital size, but AEs associated with surgical services were more likely to be severe than those associated with medical services. Some 31.4% of AEs resulted in a longer stay and 23.4% led to hospital admission. AEs associated with medical care caused 6.1 additional days per patient. Of the patients, 66.3% required additional procedures and 69.9% required additional treatments. Incidence of death in patients with AEs was 4.4% (CI 95%: 2.8–6.5). Age over 65 was associated with a higher incidence of preventable AEs. The highest percentages of preventable AEs were related to diagnosis (84.2%), to nosocomial infections (56.6%) and to care (56%). In Spanish hospitals, AEs associated with health care cause distress, disability, death, lengthen hospital stay and cause increased consumption of health-care resources. A relatively high percentage of AEs in Spain may be preventable with improvements in medical care.