gebhart/patrepeval huggingface dataset:
Abstract 1751: The influence of sex on prognostic markers for non-small cell lung cancer (2010)

Abstract There are significant differences between the sexes in the incidence, presentation, and response to therapy of non-small cell lung cancer (NSCLC). This study evaluated the effects of these differences on mRNA-based prognostic markers. Several prognostic markers have been developed over the past decade by various groups, generally from microarray datasets. These markers look at the mRNA levels of specific genes and use these to determine whether a patient is likely to good or poor outcome. If such markers were successful at complementing traditional staging criteria (i.e. molecular sub-staging) then patients predicted to have poor outcome could receive additional or more intensive therapies. Surprisingly, to date, the effect of sex on such markers has not been evaluated, despite major differences in disease between males and females. To evaluate this issue, I compiled the data from nine transcriptomic studies of primary NSCLC. These studies were integrated using a novel normalization approach and then subject to meta-analysis. For each gene present in the analysis (16,391 in total), the univariate prognostic capacity was calculated separately for men and women using median dichotomization and Cox proportional hazards modeling. Of the top 100 genes in each sex, only 12 were overlapping. Novel sex-specific prognostic signatures were then derived, and shown to out-perform sex-independent signatures by a statistically significant (p &lt; 0.01) margin. In summary, sex plays a major role in NSCLC etiology and response to therapy. I have demonstrate here that it also greatly effects the efficacy of transcriptomic prognostic markers. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1751.
Emitter Location Independent of Systematic Errors in Direction Finders (1980)

A scheme is suggested for the passive location of radio emitter position by using a mobile direction finder. The vehicle carrying the direction finder is made to maneuver such that the apparent direction of arrival is held constant. The resulting trajectory of the vehicle is a logarithmic spiral. The true direction of arrival can be obtained by monitoring the parameters of the spiral trajectory without using the value of the direction fimder reading. Two specific algorithms to eliminate direction finder bias are presented and their sensitivity to random errors in measurement assessed.
Depletion effect and precision of measurement in the digital polarography (1971)

ディジタル・ポーラログラフィーにおける拡散電流の測定精度は,水銀滴の加算滴数nのとき,1/√nに比例して向上し,電解開始の最初の滴からは30滴,また希薄効果による電流の減少が一定になる第10滴からは第15滴までの電流を加算することにより,1×10-3Fカドミウムイオンの測定において,変動係数は0.0005である.電流-時間曲線の対数プロットは,電解最初の滴では直線関係を示すが,第2滴とそれに続く滴の電流-時間曲線の対数プロットは,電解による希薄効果の影響を受けて直線関係を示さない.希薄効果は,水銀滴の生長の初期で著しく,また水銀滴下電極の先端の外径が大きいと大きく現われる.
Traffic performance and mobility modeling of cellular communications with mixed platforms and highly variable mobilities (1998)

In modeling teletraffic performance of mobile cellular networks, previous work has made use of the concept of dwell time-a random variable that describes the amount of time a platform remains in a cell, sector, or microcell. The dwell time was characterized as a negative exponential variate or the sum of negative exponential variates. With a suitable state description, this allows the use of the memoryless property of negative exponential variates with the result that the problem of computing the traffic performance characteristics can be cast in an underlying framework based on multidimensional birth-death processes. Many alternative system configurations and issues can be investigated using this approach. In small cell (microcellular) systems, however, cell sizes tend to be much less regular in shape and size, and differences in paths traversed by mobiles have a large impact on dwell time realizations. Succinctly, some mobile platform classes have mobility characteristics that are highly variable, in that the dwell time standard deviation is greater than the mean. The previous models, in which the dwell time is a negative exponential or sum of exponential variates, may not be adequate in such cases because they can only accommodate dwell time variates for which the standard deviation does not exceed the mean. We extend the analytical framework so that highly variable mobilities can be considered while insights, tools, approaches, and formulations that are facilitated by the framework can be exploited. The approach allows computation of major teletraffic performance characteristics for cellular communications in which mobility issues are important. We consider multiple platform types as well as cutoff priority for handoffs. Additional issues can be considered using this same approach. Computational issues are discussed, and some theoretical performance characteristics are obtained to demonstrate the method and compare with previous work.
Battleships Vital to Command of the Seas (1925)

Essay| December 01 1925 Battleships Vital to Command of the Seas Philip Andrews Philip Andrews Rear Admiral, United States Navy, Commandant, First Naval District; formerly Commander of the American Naval forces in Europe. Search for other works by this author on: This Site PubMed Google Scholar Current History (1925) 23 (3): 394–397. https://doi.org/10.1525/curh.1925.23.3.394 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Philip Andrews; Battleships Vital to Command of the Seas. Current History 1 December 1925; 23 (3): 394–397. doi: https://doi.org/10.1525/curh.1925.23.3.394 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1925 by The Regents of the University of California1925 Article PDF first page preview Close Modal You do not currently have access to this content.
Mechanisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase overaccumulation in three compactin-resistant cell lines. (1985)

We have isolated three mammalian cell lines which are resistant to compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. The drug resistance in all three cell lines is due to an increase of HMG-CoA reductase activity. Two of the three cell lines overaccumulate HMG-CoA reductase messenger RNA when grown in the presence of compactin. DNA hybridization experiments indicate that both a baby hamster kidney-derived compactin-resistant cell line, C100, and a cell line derived from mouse 3T6 cells, 3T6-40, exhibit amplifications of the HMG-CoA reductase gene. A third compactin-resistant cell line derived from Chinese hamster ovary cells, ML100, does not exhibit an amplification of the HMG-CoA reductase gene, nor does it show an elevated level of HMG-CoA reductase mRNA, comparable to that seen in the other cell lines.
Operating mode transition control of a SiC integrated DC DC powertrain charger for electric vehicles (2017)

In this paper, a control strategy of an integrated, reconfigurable DC-DC converter for plugin electric vehicles (EVs) is proposed. The integrated converter, capable of operating in both traction and charging modes, can be reconfigured as an interleaved boost or a dual active bridge (DAB) converter. The existing contactors of the battery management system (BMS) are used for reconfiguration between the boost and DAB modes. To maximize overall power conversion efficiency during traction operation, the converter is dynamically reconfigured to operate in the mode with highest efficiency at the present operating point. A switching transition control approach is developed for fast and seamless switching, ensuring zero-voltage turn-on and zero-current turn-off of the BMS contactors. The smooth transitions minimize switching-induced degradation of the BMS contactors, and allow uninterrupted power delivery during mode transitions. The experimental results of the prototype are presented to verify the functionality of the proposed control approach.
The Design and Early Performance History of Two Waterflood Pilots in the Mauddud Carbonate Reservoir, North Kuwait (1998)

Abstract The Mauddud formation is a major oil bearing carbonate reservoir in North Kuwait. Historical Production (spanning over 40 years) has confirmed that the reservoir receives very little natural pressure support. This has resulted in a declining reservoir pressure and low recovery factor. The forward development plan is to waterflood the Mauddud, increasing production rate and ultimate recovery. An assessment of the reservoir suggests that a pattern waterflood will be required to achieve the aggressive production profile while meeting targets for increased, ultimate reserve recovery. The waterflood pilot project (WFP) was planned to gather actual field data on waterflood performance in representative areas of the reservoir. A thorough screening of the available reservoir data was conducted in order to select suitable locations for the pilots. A limited area 3D seismic survey was shot over these locations to further check that no major reservoir anomalies were present in the planned pilot areas. Two inverted five spot pattern waterfloods were planned and constructed, one in each of the Raudhatain and Sabriyah fields. Production wells were completed with artificial (gaslift) lift capability to allow continued production as watercuts increased. A novel twin ESP source water system was constructed to take water from a deep aquifer source and pump this into the injection well at the necessary rate and pressure. A comprehensive data acquisition programme during the well construction and commissioning phase of the project allowed the essential base reservoir data to be acquired. A multiwell interference/Pulse test was conducted in both pilot areas prior to the start-of full production/injection, this confirmed good connectivity within the pilot areas. Full pilot operation commenced in June 97, with first water breakthrough (in some of the production wells) being observed 2–3 months after start-up. this was within the range of earlier predictions The pilot waterflood has already given a valuable insight into the performance of the Mauddud under waterflood conditions and the pilot results indicate the Mauddud can be successfully developed by adopting a pattern waterflood approach. Injectivity and productivity have been better than expected and the implications for sweep efficiency /directionality and reserve recovery look encouraging.
A simulation bed to investigate the feasibility of a TDD DS CDMA residential indoor system underlay (2002)

A simulation bed to investigate the feasibility of a CDMA based indoor residential system underlay that uses time division duplexing and dynamic channel allocation is described. The indoor system in question shares the same frequency band as the outdoor ANSI-008 based cellular PCS network and operates within its coverage area. Due to the TDD nature of the residential system, both the forward and reverse link signals are transmitted in the same frequency band in different time slots. Dynamic channel allocation (DCA) is used to select either the PCS uplink or the PCS downlink frequency band for the indoor system operation. The developed simulation bed measures the effects of the indoor system to the outdoor system and vice versa. System capacities, outages, DCA usage rates and blockage rates are measured using the simulator. The simulation results show that underlaying such an indoor residential system to the existing ANSI-008 PCS system is feasible. In a given geographical area, addition of such a system would ultimately increase the CDMA capacity substantially.
A simple spreadsheet-based, MIAME-supportive format for microarray data: MAGE-TAB (2006)

MAGE-TAB will enable laboratories without bioinformatics experience or support to manage, exchange and submit well-annotated microarray data in a standard format using a spreadsheet. The MAGE-TAB format is self-contained, and does not require an understanding of MAGE-ML or XML.
[The study of transformation of tobacco with the stress responsible gene BoRS1 from Brassica oleracea var. acephala]. (2005)

Transgenic tobacco plants expressing a stress responsive gene BoRS1, isolated from Brassica oleracea var. acephala, under the control of the 35S promoter of the Cauliflower mosaic virus were produced. Some plants were further used to test the effect of high level BoRS1 expression on drought stress resistance. The presence of transgene in putative transgenic plants was confirmed by PCR analysis. Thirty-six among 130 transformants showed amplification of predicted fragment of BoRS1 while no amplification was observed in the control. Some transgenic lines confirmed by PCR analysis were analyzed through semi-quantitative one-step RT-PCR for the expression of BoRS1 gene. Amplification of 1.4 kb cDNA product revealed transcription of BoRS1 gene. Meanwhile, differential intensity of the cDNA band indicated variable expression levels of the transgene among different transformed lines. The water loss of detached leaves from the transgenic plants was slower than that of the control. Transgenic tobaccos and the non-transgenic controls were used for further drought stress experiments by using different concentration of mannitol. The transformants showed higher tolerance to drought stress than non-transgenic plants and different transgenic lines exhibited different tolerance during drought stress. These results showed that the BoRS1 gene probably play role in enhancing the ability to drought stress.
Induction of an activation antigen on postcapillary venular endothelium in human skin organ culture. (1987)

We studied the effects of the immune mediators interleukin 1, interleukin 2, tumor necrosis factor, immune interferon, and lipopolysaccharide on the expression of the endothelial activation antigen recognized by the murine monoclonal antibody H4/18 in short term organ cultures of newborn foreskins. No endothelial staining was detectable before culture. Interleukin 1, tumor necrosis factor, and lipopolysaccharide each induced 2+ to 3+ H4/18 staining of microvascular endothelium at 6 hr. Combining mediators produced additive (3+ to 4+) effects, and reactivity was lost or markedly diminished by 24 hr. Incubation with culture medium alone resulted in 1+ to 2+ H4/18 staining at 6 hr, and medium conditioned by cultured foreskins, but not mock-conditioned medium, could induce H4/18 binding in cultured human umbilical vein endothelial cells. The spontaneous expression of microvascular staining in the foreskins was markedly inhibited by cyclosporin A, but not polymyxin B sulfate or dexamethasone; cyclosporin A did not inhibit induction of staining by exogenous mediators. Both light level and immunoultrastructural studies demonstrated H4/18 expression to be associated predominantly with postcapillary venular endothelial cells of the superficial vascular plexus. We conclude that microvascular endothelium of skin can undergo activation in response to exogenous and endogenous cytokines, with the greatest changes occurring in those portions of the vessels most involved in leukocyte and lymphocyte trafficking.
The Policies of Social Innovation: A Cross-National Analysis (2019)

This article deals with the policy discourse on social innovation at the European Union (EU) level as well as across nine European countries. We perform an exploratory analysis of relevant policy documents focusing on articulated policy authority, suggested actors, and key outcomes of social innovation. We also conduct an explanatory testing of the applicability of the varieties of capitalism as a traditional innovation classification system to social innovation. We find that the policy discourse across Europe lacks systemization and that EU agendas are only incompletely replicated at the individual country level. We also find that social innovation policies largely defy the principles governing traditional innovation policy regimes, which necessitates new or revised classification frames.
ChemInform Abstract: A Search for Maximal Neighboring Group Participation in Solvolyses of Allylic Substrates. Ethanolysis of 2‐(ω‐Alkylthioalkyl)‐3‐methyl‐ 2‐cyclohexenyl p‐Nitrobenzoates (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In vitro and in vivo antibacterial activity of FR-31564, a phosphonic acid antimicrobial agent (1981)

The in vitro and in vivo activity of FR-31564 [sodium hydrogen 3-(N-hydroxyformamido)propylphosphate] against gram-positive and -negative aerobic and anaerobic bacteria was investigated and compared with that of fosfomycin, cephalexin, carbenicillin, and trimethoprim-sulfamethoxazole. The in vitro activity of FR-31564 was markedly enhanced when combined with glucose 6-phosphate or fructose 6-phosphate, but not when combined with ribose phosphate, adenosine monophosphate, or glycerol phosphate. In vitro activity of FR-31564 also was enhanced by human or horse blood, but not by human serum. The type of medium had a great effect on the minimal inhibitory concentration, with the lowest minimal inhibitory concentrations achieved on nutrient agar, 8- to 16-fold less than with Mueller-Hinton, heart infusion, or Trypticase soy agars. FR-31564 was more active than fosfomycin, cephalexin, carbenicillin, or trimethoprimsulfamethoxazole against Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Enterobacter cloacae, E. aerogenes, and Citrobacter. It was less active than fosfomycin against Serratia marcescens and Proteus mirabilis and did not inhibit gram-positive cocci or anaerobic species. FR-31564 inhibited a number of E. coli, K. pneumoniae, and some Pseudomonas aeruginosa strains resistant to the other agents. In the presence and absence of human blood FR-31564 showed bactericidal activity, and P. aeruginosa exposed to FR-31564 for 3 h showed a 6-h lag in regrowth. FR-31564 administered by the subcutaneous route was more active in protecting mice challenged with P. aeruginosa than was fosfomycin, carbenicillin, or cefoperazone. It was as active by the oral route in protecting mice challenged with E. coli as was fosfomycin, ampicillin, cephalexin, or trimethoprimsulfamethoxazole.
Quantisation effects in FIR filters: fixed versus floating point (1989)

Floating point implementations are more complex than fixed point (by a factor of up to three for typical hardware realisations), but are generally assumed to offer reduced quantisation errors. In this contribution a comparison is made between the use of fixed and floating point arithmetic for FIR filters. It is argued that in many applications the performance of the simpler fixed point arithmetic can equal or exceed that of floating point by means of a modest increase in wordlength. >
Partial argentation resin chromatography (PARC): III. the effects of sodium ion incorporation and solvent on the separation of mixtures of fatty acids, of fatty esters, and of triglycerides (1981)

Abstract Partial argentation resin chromatography (PARC) was used to separate mixtures of fatty acids, of fatty esters and of triglycerides. Various eluting solvents (methanol, acetone, ether, benzene) were investigated and acetone was the preferred solvent. To prevent acid‐catalyzed condensation of the acetone, the sulfonic acid protons of the XN1010 resin were replaced with sodium ions before silver ion incorporation. Atomic absorbtion spectrophotometry was used to determine the number of silver ions incorporated per volume of resin. A mixture containing stearic, elaidic and oleic acids was separated on a saturated silver resin column. A commercially available sample of linoleic acid was purified on a 53% PARC column (meaning 53% of the available sulfonic acid protons in the resin were replaced by silver ions). A 39% PARC column was used to separate a mixture of linseed acids. Methyl linoleate, linolenate and arachi‐donate also were isolated on a 39% PARC column. A mixture containing triolein, trilinolein and trilinolenin was separated on a 32% PARC column.
DFM for manufacturers and designers (2005)

At 90nm and 65nm, the semiconductor industry is condemned to use 193nm steppers and an overwhelming amount of resolution enhancement techniques (RET). Even when using the best RET solution available, some designs are more amenable to manufacturing than others and their initial yield or startup yield is higher. Design for manufacturing (DFM) has been a hotly discussed topic in both electronic design automation (EDA) and manufacturing communities, and to date much debate remains regarding its precise definition, let alone the solution. However, it is rather intuitive that, whatever the solution is, DFM needs to simultaneously satisfy several objectives in terms of optimizing yield, manufacturing cost and manufacturing friendliness; being transparent to the designer; protecting manufacturing intellectual property (IP); and having a sensible implementation. In this paper, we will describe a suitable technology that satisfies the data information sharing to ensure that both designers and manufacturers fulfill the expected initial and volume yield expectations. We describe how this technology may be applied pre- and post-tapeout to fulfill both designer and manufactures requirements.
Effectiveness of β<sub>2</sub>-Microglobulin Adsorption Column in Treating Dialysis-Related Amyloidosis: A Multicenter Study (2011)

Treatment with Lixelle reduces the radiolucency of bone cysts in the wrist joints, and improves clinical symptoms associated with DRA.
Spectral Filtering At A Spatial Filter: Design Principles For Star Simulators (1985)

Many optical systems are designed to operate with radiation that is received from distant point sources such as stars or target hot-spots. In order to test such systems, one must build a star simula-tor that spatially filters the radiation from a laboratory source. In this paper, we will discuss the design principles for such a simulator. The design becomes complicated in that the spatial filter assembly also provides spectral filtering on the laboratory source. This effect is calculated and various compensation methods are discussed.
In vitro effect of cyclosporin A on immunoglobulin production and concanavalin A induced suppression in primary biliary cirrhosis. (1986)

The in vitro effect of Cyclosporin A on the regulation of immunoglobulin production was investigated in 16 patients with primary biliary cirrhosis. A significant improvement in concanavalin A induced suppression of IgG and IgM producing cells was observed after prior incubation of mononuclear cells with 300 ng/ml Cyclosporin A for 30 minutes. No effect was seen on spontaneous or pokeweed mitogen induced immunoglobulin production, nor on con A induced suppression if Cyclosporin A was added after 24 hours. Incubation of mononuclear cells with a variable dose of Cyclosporin A showed an effect only at 250-500 ng/ml. Higher and lower doses had no effect. This dose dependent effect of Cyclosporin A is likely to be related to a differential inhibitory effect on T helper and T suppressor cells and may underlie the clinical benefit being observed in current clinical trials.