gebhart/patrepeval huggingface dataset:
Network Equipment and Their Procurement Strategy for High Capacity Elastic Optical Networks (2016)

In elastic optical networks, the success of providing high network capacity depends on the optical signal-to-noise ratio (OSNR) values of network lightpaths. As each lightpath's OSNR value defines the modulation format and capacity it can support, having high OSNR light-paths is always beneficial. Hence, with a given set of modulation formats, service providers need to optimize their optical infrastructure, including in-line amplifiers and reconfigurable optical add-drop multiplexers (ROADMs), given the size and topology of their core networks. This also will have a direct impact on vendors who need strong insight into the requirements of service providers and their networks in terms of equipment and new technology. Therefore, in this paper a comprehensive model based on the local optimization which leads to a global network optimization (LOGON) strategy of the Gaussian noise (GN) model has been proposed, which helps in estimating the lightpath OSNR and clearly quantifies the noise contributions from in-line amplifiers and post-amplification at the ROADMs. The model introduces closed-form expressions to calculate nonlinear impairment (NLI) contributions for various span lengths while using either erbium-doped fiber amplifiers (EDFAs) or H-Raman amplifiers, which helps in optimizing the signal launch power to achieve maximum link OSNR In addition to this, an offline strategy has been proposed that can help service providers to optimize their procurement of network equipment upfront and give insight into how much of the capacity bottleneck is alleviated in their networks if they do this. To demonstrate all of the above, the UK, Pan-European, and US Core networks have been considered, which illustrate differences in link lengths and reduced node density. It is seen that improving the OSNR conditions at the ROADM increases the network capacity when noise from in-line amplifiers is significantly reduced. Among the three networks, we found that the UK network responded the most to improved OSNR conditions at the ROADM nodes due to small link lengths and less line noise. Among the amplifiers, we found that improving ROADMs while having H-Raman in the links resulted in a maximum capacity increase. For the UK network at FG = 12.5 GHz, the capacity increases by 6650 Gbps, while for the larger Pan-European and US networks, the capacity increase reduces to 4550 and 1600 Gbps due to increased link lengths and line noise. Further, following the offline strategy, we are able to accommodate 1737, 1481, and 615 100G demands using H-Raman for the UK, Pan-EU, and US networks at FG = 12.5 GHz until 10% blocking is reached. Thereby, H-Raman provides 7.5%, 35.8%, and 94.9% extra capacity, respectively, for the UK, Pan-EU, and US. Finally, using H-Raman, all lightpaths in the UK network operate at PM-64QAM with maximum capacity at the end of the procedure.
siRNA containing a unique 5-nucleotide motif acts as a quencher of IFI16-mediated innate immune response (2019)

We previously reported that some small interfering RNA (siRNA) enhances DNA or DNA virus mediated-interferon (IFN)-λ1(a type III IFN) induction through the crosstalk between retinoic acid-inducible gene I (RIG-I) and interferon gamma-inducible protein 16 (IFI16) signalling pathway. Here we provide further evidence of a new role for siRNA. siRNA containing a 5-nucleotide (nt) motif sequence suppresses DNA-mediated not only type III IFNs, but also type I IFNs and inflammatory cytokines. We define that motif siRNA inhibits the induction when the motif is located at the 3' or 5'-terminus of siRNA. Using THP1-Lucia ISG cells with various DNA stimulants, we reveal that motif siRNA inhibits DNA or DNA virus but not RNA virus-mediated signalling. Motif siRNA specifically interrupts IFI16 but not cyclic GMP-AMP synthase (cGAS) binding to DNA and has 2.5-fold higher affinity to IFI16 than that of siRNA without the motif. We further confirm that motif siRNA potently suppresses HSV-1 virus-mediated IFNs and inflammatory cytokines, such as IFNL1, IFNB and TNFA, in human primary immature dendritic cells. Collectively, these findings may shed light on a novel function of siRNA with the unique 5-nt motif as a quencher of innate immunity and facilitate the development of potential therapeutics to regulate innate immune cascades.
THE NICKEL END OF THE TERNARY SYSTEM NICKEL-ALUMINUM-BORON (1962)

The nickel end of the ternary system nickel- aluminumboron was described by means of the fusion projection and of an isothermal cross section at 800 deg C. In addition to the known phrases in both binary boundary systems, nickel- aluminum and nickel - beron, a congruent fused ternary boride Ni/sub 60/Al/sub 9/ B/sub 31/ occurs. Its structure is cubic (D8/sub 4/ type) and its lattice constant is 10.55 A. Both the fusion surface of the ternary boride and its homogeneity range are sharply expanded. (tr-auth)
Ampicillin/Sulbactam Versus Ampicillin Alone for Cesarean Section Prophylaxis: A Randomized Double-Blind Trial (1995)

To study the effectiveness of anaerobic coverage in prevention of postpartum endometritis in women undergoing nonelective cesarean sections, we conducted a randomized prospective double-blind study of women undergoing cesarean sections and requiring antibiotic prophylaxis from April 1, 1989, through December 31, 1990. Ninety-four patients were enrolled in the study. Forty-five patients received ampicillin alone and 46 received ampicillin in conjunction with sulbactam. All patients were evaluated prior to surgery and in the postoperative period. Ninety-one patients completed the study and their records were analyzed. Patients were divided into two groups depending on the presence or absence of ruptured membranes. Seventy-five percent of patients had ruptured membranes. Failure of prophylaxis and subsequent endometritis was documented in 8.8% of patients who received ampicillin and sulbactam and 35.3% of patients who received ampicillin alone. This difference was statistically significant (p < 0.02). In conclusion, single-dose ampicillin and sulbactam provides better prophylaxis than single-dose ampicillin in women undergoing cesarean section with rupture of membranes.
Repetitive Treatments of Colon HT‐29 Cells with Diallyl Disulfide Induce a Prolonged Hyperacetylation of Histone H3 K14 (2004)

Diallyl disulfide (DADS) is a sulfur compound derived from garlic. Several studies carried out in rodents have revealed protective effects of DADS against colon carcinogenesis. The antipromoting effects of DADS may be partly related to its ability to inhibit tumoral cell proliferation. In a previous study, we have shown that in two human colon tumor cell lines (HT-29 and Caco-2) seeded at a low density (0.2 x 10(6) cells/100-mm petri dish), DADS antiproliferative effects were associated with a transient increase of histone H3 K14 acetylation. Moreover, DADS could inhibit nuclear histone deacetylase activity. Therefore, in the present study, we examined the possible effects of different experimental conditions (HT-29 cells at high density, repetitive treatments with DADS) on the pattern of DADS-induced histone hyperacetylation. Using HT-29 cells seeded at a higher density (5 x 10(6) cells/100-mm petri dish), we found that DADS induced histone H3 K14 hyperacetylation rapidly (3 h). When administrated as single treatments, the DADS effect on histone H3 K14 remained transient. In contrast, repetitive treatment with DADS resulted in a prolonged hyperacetylation of histone H3 K14. Whatever the cell culture conditions were, DADS had no effect on histone H4 acetylation. Thus, in vitro, the cell density and pattern of DADS treatment influenced the HT-29 nuclear response to DADS. DADS belongs to food-borne molecules that may play a role in chromatin remodeling and contribute to the nutritional modulation of gene expression.
ChemInform Abstract: BUFADIENOLIDE 8. MITT. 12(13‐14)ABEO‐SKELETT‐UMLAGERUNG (1970)

Abstract Umsetzung von Digitoxigenin (I) mit Kaliumhydroxid/Methanol (1 Std. bei 15°C) ergibt Isodigitoxigenin (II) (64% Ausbeute) und Isodigitoxigeninsäure (III) (27%).
Effect of HPT on the First Hydrogenation of LaNi5 Metal Hydride (2021)

This paper reports the effect of high-pressure torsion (HPT) on the first hydrogenation of LaNi5. We found that, for loose powder, reduction of particle size has an effect of increasing the incubation time and decreasing the hydrogen capacity. A higher amount of HPT turns only marginally reduce the incubation time but has no effect on hydrogen capacity. In all cases, the first dehydrogenation and subsequent hydrogenation have the same kinetics, irrespective of the particle size or number of HPT turns. Therefore, for LaNi5, HPT has a beneficial effect only for the first hydrogenation.
ChemInform Abstract: 4‐JOD‐ UND 4‐CYAN‐PYRROL‐2‐ALDEHYDE (1973)

Abstract Die Pyrro1ylmethylen‐pyrrolidinium‐Salze (Ia) und (Ib) reagieren mit Trifluoracetylhypojodit zu den 4‐Jod‐pyrrol‐aldehyden (IIa) und (IIb), die mit CuCN zu den Nitrilen (IIIa) und (IIIb) austauschen.
Matched Unrelated Bone Marrow Transplant for Omenn Syndrome (2009)

Little information is currently available on the outcome and the long term restoration of immune function in infants with Omenn syndrome (OS) treated with bone marrow transplantation (BMT). We prospectively followed patients with OS who received matched unrelated donor bone marrow transplantation at our center. Engraftment, immune reconstitution and transplant-related complications were recorded. Humoral and cellular immunity were evaluated. Six patients with OS were diagnosed at a mean age of 4.6 months. Two had mutations in the RMRP gene, one had mutations in DNA Ligase 4, while the rest genotype could not be determined. They received a matched unrelated donor bone marrow transplantation as the first BMT at the mean age of 9.4 months. All six patients are alive and well at a mean 95 months after transplant. All patients have evidence of full hemopoetic engraftment and robust immune reconstitution. Three out of six patients developed GvHD of Grade II or more, which was reversed in all patients by using short courses of high dose methylprednisolone. We have shown here that matched unrelated donor bone marrow transplantation is highly effective in curing patients with Omenn syndrome regardless of their genotype. This mode of treatment should be preferred for patients with OS when a related identical donor is not available.
Asymmetric Catalysis. Part 152. α‐Amino Acid Derivatives by Enantioselective Decarboxylation. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10. (1994)

In these studies we show that although purified B cells of patients with common variable immunodeficiency (CVI) have a normal capacity to proliferate, they manifest differentiation defects at multiple levels. Compared with controls, circulating CVI B cell populations contain reduced numbers of sIgG+ and sIgA+ cells with a commensurate increase in sIgM+ B cells, suggesting an in vivo defect in isotype switch. In addition, CVI B cells manifest Ig secretion defects on stimulation with either anti-CD40 and IL-10 or SAC and IL-2 and IL-10, which are of increasing severity for IgM, IgG, and IgA, respectively. These Ig secretion defects are not overcome by addition of a variety of cytokines, including TGF-beta, to anti-CD40-driven cultures. In further studies we show that despite the above abnormalities, CVI B cells are induced to express normal or near-normal levels of C mu, C gamma, and C alpha mRNA after 7 days of stimulation with anti-CD40 and IL-10. That this CH mRNA expression represents a recovery of CVI B cell differentiation is supported by studies of Ig secretion in which CVI B cells that are first stimulated for 7 days with anti-CD40 and IL-10 and then restimulated in coculture with activated normal allogeneic T cells and IL-10, secrete substantial levels of IgM and IgG and increased amounts of IgA. Overall, therefore, CVI B cell function can be significantly improved by maintenance in culture. These data suggest the abnormalities of B cell differentiation in CVI are reversible and that the defect is a form of B cell anergy.
1-Aminoacyl-2,3-dihydro-4(1H)-quinazolinone derivatives with choleretic and antifibrillatory activity (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Aminoacyl-2,3-dihydro-4(1H)-quinazolinone derivatives with choleretic and antifibrillatory activityG. Bonola, P. Da Re, M. J. Magistretti, E. Massarani, and I. SetnikarCite this: J. Med. Chem. 1968, 11, 6, 1136–1139Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/jm00312a007https://doi.org/10.1021/jm00312a007research-articleACS PublicationsRequest reuse permissionsArticle Views279Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leitlinien für die hausärztliche Behandlungspraxis (2000)

Im Hinblick auf die Entwicklung von Leitlinien für die hausärztliche Behandlungspraxis ist zunächst der Rahmen wichtig, in dem sich der Hausarzt bewegt. Dazu gehört zum einen das Spannungsfeld zwischen Patient und dessen Angehörigen, zum anderen eine gute ärztliche Einbindung in das Versorgungssystem einer Kommune oder eines Kreises. Ein Hausarzt sollte gute Kontakte zu einer Vielzahl von Facharztkollegen pflegen. Es ist wichtig, dass der Hausarzt im Hinblick auf ihn überfordernde psychische Probleme seiner Patienten jederzeit Kontakt zu einem oder zwei Nervenärzten findet, denen er vertraut und mit denen er eng zusammenarbeitet. Auch der Kontakt zu einem Klinikarzt oder zu einer an eine Klinik angelehnte Institutsambulanz kann eine wertvolle Hilfe sein, um Patienten im Notfall rasch einer stationären Behandlung zuführen zu können.
Étude et réalisation de réseaux pour lasers InGaAsp 1,5 μm à contre-réaction distribuée (1987)

L'objet de ce travail est l'introduction, dans la technologie des diodes lasers InGaAsP 1,5 micron, de la fabrication d'un reseau de diffraction necessaire a la contre-reaction distribuee. Apres un rappel theorique des principaux parametres de la structure, nous proposons une optimisation de la geometrie du reseau en tenant compte des contraintes technologiques de la gravure. Nous avons retenu pour la realisation du reseau une technique d'insolation holographique. Differents interferometres ont ete testes. Nous avons retenu un systeme automatise a interfrange variable dans la gamme 200-500 nm. Un programme informatique de simulation des attaques chimiques nous a permis de preciser la composition de la solution utilisee pour le transfert du reseau dans le semi-conducteur et d'interpreter nos resultats experimentaux en prenant en compte les proprietes cristallographiques de la gravure du phosphure d'indium et des composes associes. Cette technique a permis la realisation de reseaux correspondant au deuxieme aussi bien qu'au premier ordre de couplage. Par ailleurs nous montrons les possibilites qu'offre l'usinage ionique pour le transfert des reseaux et l'optimisation du couplage. Nous avons verifie la compatibilite du masque holographique de resine avec ce moyen de transfert en realisant des reseaux du deuxieme ordre. La realisation d'une diode laser a contre reaction distribuee necessite une etape de reprise d'epitaxie sur le reseau. Nous avons participe a la definition des conditions experimentales de croissance permettant de reduire les deformations du profil grave. En conclusion, nous donnons les caracteristiques de diodes lasers realisees au laboratoire. Le meilleur courant de seuil est de 30 mA en impulsion et 35 mA en continu. L'etude du spectre en longueur d'onde permet de deduire une valeur du coefficient de couplage de 90 cm-1 attestant de la bonne conservation du reseau lors de l'epitaxie.
Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content (2012)

SCFA are produced in the gut by bacterial fermentation of undigested carbohydrates. Activation of the Gα i -protein-coupled receptor GPR41 by SCFA in β-cells and sympathetic ganglia inhibits insulin secretion and increases sympathetic outflow, respectively. A possible role in stimulating leptin secretion by adipocytes is disputed. In the present study, we investigated energy balance and glucose homoeostasis in GPR41 knockout mice fed on a standard low-fat or a high-fat diet. When fed on the low-fat diet, body fat mass was raised and glucose tolerance was impaired in male but not female knockout mice compared to wild-type mice. Soleus muscle and heart weights were reduced in the male mice, but total body lean mass was unchanged. When fed on the high-fat diet, body fat mass was raised in male but not female GPR41 knockout mice, but by no more in the males than when they were fed on the low-fat diet. Body lean mass and energy expenditure were reduced in male mice but not in female knockout mice. These results suggest that the absence of GPR41 increases body fat content in male mice. Gut-derived SCFA may raise energy expenditure and help to protect against obesity by activating GPR41.
The true risk of blood transfusion after nephrectomy for renal masses: a population‐based study (2013)

The transfusion rate after nephrectomy in general clinical practice is higher than that reported in the urological literature. Patient and provider factors appear to contribute to the considerable variability that exists in the observed transfusion rate. A more detailed understanding of these factors may help with respect to preoperative patient counselling and informed consent.
Robust man-machine interfaces and dialog modelling (1982)

A number of projects at the Carnegie-Mellon University Computer Science Department address issues in Natural Language Processing. Since several of these projects share rescarchers and a similar view of the world, we have listed them in a single summary. Our general interests are in robust man-machine interfaces and the modelling of human dialogs.
Web-based credentialing streamlines data-driven process (2008)

Professionals with problematic and tarnished credentials pose serious risk to healthcare consumers and create financial exposure – in the form of CMS fines -- for the institutions that unknowingly employ them. This black cloud now extends to health plans.
High Rate Anodic Dissolution of Copper (1969)

The anodic dissolution of copper at current densities of 10–150 A/cm2 has been studied in neutral and solutions. An experimental flow system has been built which allows electrochemical measurements of the dissolution process to be performed under denned hydrodynamic conditions typical for the technical electrochemical machining operation. Design criteria for such a system have been analyzed. Copper dissolution proceeds in an active or a transpassive mode which differ in overvoltage by 10–20V. The onset of passivation seems to be due to the limiting mass transfer of dissolved metal from the electrode surface. The still higher dissolution rates in the passive state appear to be made possible by the removal of solid dissolution products. Etched, dull surfaces have resulted from active dissolution; pitted, bright surfaces from passive dissolution.
Automated Audience Segmentation Using Reputation Signals (2018)

Selecting the right audience for an advertising campaign is one of the most challenging, time-consuming and costly steps in the advertising process. To target the right audience, advertisers usually have two options: a) market research to identify user segments of interest and b) sophisticated machine learning models trained on data from past campaigns. In this paper we study how demand-side platforms (DSPs) can leverage the data they collect (demographic and behavioral) in order to learn reputation signals about end user convertibility and advertisement (ad) quality. In particular, we propose a reputation system which learns interest scores about end users, as an additional signal of ad conversion, and quality scores about ads, as a signal of campaign success. Then our model builds user segments based on a combination of demographic, behavioral and the new reputation signals and recommends transparent targeting rules that are easy for the advertiser to interpret and refine. We perform an experimental evaluation on industry data that showcases the benefits of our approach for both new and existing advertiser campaigns.
Portuguese Man-of-War Envenomization: A Personal Experience (1967)

THE FOLLOWING is a description of a systemic reaction to the sting of a Portuguese Man-of-War; the sting occurred while I was on a training exercise with the 8th Special Forces Group SCUBA Team in Limon Bay, Canal Zone. Report of a Case While swimming at a depth of 15 feet, I felt a sudden severe stinging sensation on the right shoulder, as though a hot iron had been placed there. The shock of the contact was sufficient to bring about an involuntary jerking and thrashing in the water. Within seconds there began a sensation of tightness in the chest and a bilateral subcostal constriction. The burning in the shoulder spread rapidly to include the upper arm, and cramping began deep in the hypogastrium. Concurrently there were abdominal skeletal muscle spasms and waves of paresthesias of a tingling nature which started in the shoulder and moved over the body. Within
Cyclic AMP decreases the phosphorylation state of myelin basic proteins in rat brain cell cultures. (1987)

Previous work has suggested that myelin basic proteins are phosphorylated prior to their appearance in the myelin sheath (Ulmer, J. B. and Braun, P. E. (1984) Dev. Neurosci. 6, 345-355). In order to corroborate this finding we have examined the phosphorylation of myelin basic proteins in rat brain cell cultures containing 14-17% oligodendrocytes. Incorporation of 32P into the 14-, 17-, 18.5-, and 21.5-kDa myelin basic proteins was observed in cells incubated with 32P at 7, 14, and 21 days in culture. Myelin basic proteins in 14-day cells incorporated 32P linearly until at least 120 min after the addition of isotope. The apparent half-life of myelin basic protein phosphate groups was determined to be approximately 80 min in pulse-chase experiments. However, this value may be an overestimation due to the presence of significant levels of acid-soluble radioactivity in the cells throughout the chase period. The presence of dibutyryl cAMP or 8-bromo-cAMP in the incubation medium substantially inhibited the incorporation of 32P into the myelin basic proteins at all time points studied. The presence of dibutyryl cAMP in the chase medium in pulse-chase experiments resulted in an increase in the turnover rate of [32P] phosphate in the myelin basic proteins. These results indicate that cAMP decreases the phosphorylation state of myelin basic proteins in oligodendrocytes by inhibiting the phosphorylation and/or stimulating the dephosphorylation of myelin basic proteins.