gebhart/patrepeval huggingface dataset:
Understanding the Factors of Information Leakage through Online Social Networking to Safeguard Organizational Information (2010)

With the rapid escalation of the online social networking (OSN) use, there have been some high profile cases reported in the media about information leakage by employees that are detrimental to organizations. However, academic literature rarely discusses the impacts of OSN on organizations. This conceptual paper explores employees' OSN use behaviour that leads to the disclosure of organizational information which may jeopardize the information systems (IS) security. In order to do that, the paper briefly reviews theories from criminology, psychology and sociology that are related to our study. We find that Decomposed Theory of Planned Behaviour is the most suitable theoretical model in explaining the underlying factors that drive information leakage through OSN. The understanding of these reasons facilitates our suggestion for organizations to safeguard information against this insider threat by employing information security education, training and awareness (SETA) programs for employees. © 2010 Nurul Nuha Abdul Molok, Atif Ahmad & Shanton Chang.
Benzodiazepine receptor ligands: a patent review (2006 – 2012) (2013)

Most patents highlighted that various memory deficits, related to Alzheimer's disease, Down syndrome, mood disorders, schizophrenia, and age-related cognitive impairment may be treated using α5-selective ligands. Other aspects related to the use of allosteric modulators of the α7-nAchR and/or α5-GABA(A)-R (dual approach) for alleviating the impaired cognition and the use of α2-selective ligands for pain relief are highlighted, being particularly intriguing as new therapeutic approaches.
Ion exchange resins as drug delivery carriers (2015)

Ion exchange resin(IER) are cross-linked synthetic high molecular weight solid water insoluble usually white or yellowish, fabricated from organic polymer (polyelectrolyte) having ionizable functional group. IER have received considerable attention from pharmaceutical scientists because of their versatile properties as drug delivery vehicles. Research over the last few years has revealed that IER are equally suitable for drug delivery technologies, including controlled release, transdermal, nasal, topical and taste masking. The major drawback of sustained release of extended release or extended release is dose dumping, resulting in increased risk of toxicity. The use of IER has occupied an important place in the development of controlled- or sustained-release systems because of their better drug-retaining properties and prevention of dose dumping. Synthetic ion exchange resins have been used in pharmacy and medicine for taste masking or controlled release of drug. Drug resin complexation converts drug to amorphous form leading to improved drug dissolution. Several studies have reported the use of IER for drug delivery at the desired site of action. Sulfonated and carboxylic resins with a polystyrene backbone are most widely used in clinical medicine.
Ein neues Verfahren mit Vorrichtung zur Hysteroskopie (1971)

A special hysteroscope, total diameter: Fr. 10 (3,3 mm or approx. ⅛ inch) is introduced under visual control. Uterus and cervical channel are tightened by a riding one way-vacuum-cap. This combination enables elevations in all directions during laparohysteroscopy; instillation, biopsy and coagulation possibilities. In 1926 cases we succeeded in inserting the new hysteroscope without anaesthesia and pain.
Osteonecrose de mandíbula em pacientes com lúpus eritematoso sistêmico juvenil observada em exame de imagem (2010)

Osteonecrosis of the mandible with mild TMJ dysfunction was observed in some of the patients, demonstrating the importance of odontological assessment during clinical follow-up.
Enterochromaffin 5-HT cells – A major target for GLP-1 and gut microbial metabolites (2018)

Nutrient metabolites apparently do not stimulate EC cells of the small intestine directly but through a paracrine mechanism involving GLP-1 secreted from neighboring enteroendocrine cells. In contrast, colonic EC cells are able to sense a multitude of different metabolites generated by the gut microbiota as well as gut hormones, including GLP-1.
Call control scenarios in the "all-IP" UMTS core network (2002)

This paper gives an overview of the 3GPP "all IP" architecture for the core network of UMTS. It presents some call control and network resource allocation scenarios using SIP for multimedia call management in a packet-switched network, UMTS/GPRS network and multimedia IP-based networks.
Constitutional Discourse (1989)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsMichael DavisMichael Davis is lecturer in law at the Chinese University of Hong Kong.
Stress Analysis of a Tooth Restored with a Post and Core (1983)

An idealized axisymmetric finite element model of a second premolar restored with a post and core was used to study the distribution and magnitude of stresses as a function of the following parameters: the diameter of the post, the length and the shape of the post, and finally the interface characteristics between post and cement. Emphasis was directed toward the cement layer interposed between the post and the tooth. Bonding between the post and the cement appeared to be the most important parameter to achieve optimal mechanical behavior of the tooth-prosthesis combination.
[Gene relA function in the expression of amino acid operons. II. Effect of the allelic state of gene relA on the overproduction of threonine by an Escherichia coli K-12 mutant resistant to beta-hydroxynorvaline]. (1978)

Mutants, resistant to threonine analogue, DL-alpha-amino-beta-hydroxyvaleric acid, were obtained after the treatment of Escherichia coli K-12 RelA- cells with nitrosoguanidine, and among them the strain with maximal threonine production (about 3g/l) was selected. Genetic and biochemical analysis of the producer has revealed the dependency of the threonine production on at least three mutations. The mutation in the thrA gene disturbs retroinhibition of homoserine dehydrogenase by threonine. The mutation in the ilvA gene decreases the activity of threonine deaminase, and thus results in partial isoleucine auxotrophy, and finally, the reversion in the relA gene restores the stringent amino acid control of RNA synthesis in threonine producer cells. The role of relA gene in threonine production was demonstrated by comparing pairs of strains differing from one another in the allelic state of the relA gene. The level of threonine synthesis (its intra- and extracellular concentrations) during moderate isoleucine starvation in RelA+ cells 2-3 times as high as in RelA- cells. The presence of relA+ allele is found to result in the increase of the cell resistance to DL-alpha-amino-beta-hydroxyvaleric acid.
Yes-Associated Protein 1 Promotes Adenocarcinoma Growth and Metastasis through Activation of the Receptor Tyrosine Kinase Axl (2012)

Yes-associated protein 1 (YAP1), a nuclear effector of the Hippo pathway, plays an important role in tumorigenesis and progression of multiple cancers. The present study aimed to investigate the clinical significance of YAP1 and receptor tyrosine kinase Axl expression in human lung adenocarcinomas (LAC). We further explored possible molecular mechanisms mediated by YAP1 in LAC and gastric adenocarcinoma (GAC) cells. Forty-nine cases of human LAC and normal lung tissue (NLT) were collected. The expression of YAP1 and Axl was assessed by immunohistochemical assay through tissue microarray procedure and the clinicopathologic characteristics of all patients were analyzed. Using a loss of function approach, we investigated the effects of small hairpin RNA (shRNA)-mediated knockdown of YAP1 on the expression of Axl, proliferating cell nuclear antigen (PCNA) and matrix metalloproteinase-9 (MMP-9), and the proliferative activities and invasive potential in LAC A549 and GAC SGC-7901 cell lines. As a result, the expression of YAP1 and Axl was found in LAC tissues with higher strong reactivity rate compared to the NLT (87.8 percent vs.60.8 percent, P=0.000; 77.6 percent vs 0.0 percent, P=0.000), but they did not associate with the age, gender, tumor size, TNM staging or lymph node metastases of LAC patients (each P>0.05). Spearman rank correlation analysis showed a positive correlation between YAP1 and Axl expression. Furthermore, knockdown of YAP in vitro markedly down-regulated the expression of Axl, PCNA and MMP-9, and inhibited the proliferation and invasion of LAC and GAC cells. Taken together, YAP1 and Axl are highly expressed in LAC compared to the NLT, and knockdown of YAP1 may inhibit the proliferation and invasion of adenocarcinoma cells through downregulation of the Axl pathway, representing a potential therapeutic target for the treatment of cancer.
Synthesis and Antiviral and Antibacterial Activity of Certain N-Dialkylaminomethylisatin β-Thiosemicarbazones (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Antiviral and Antibacterial Activity of Certain N-Dialkylaminomethylisatin β-ThiosemicarbazonesRajendra S. Varma and W. Lewis. NoblesCite this: J. Med. Chem. 1967, 10, 5, 972–974Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/jm00317a061https://doi.org/10.1021/jm00317a061research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Easy Ways of Going Round the Bend (1973)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Biomarkers in Renal Transplantation (2008)

Identifying surrogate markers of renal allograft outcome and biomarkers of acute and chronic graft injury is a critical issue for the transplant community. Measurement of serum creatinine and biopsy remain the current gold standards for the evaluation of renal allografts. These tests have significant limitations in predicting which patients are destined for immune tolerance or immune-mediated graft loss, and aiding in the management of long-term immunosuppression. The goal of biomarkers is to diagnose rejection early, determine prognosis and tailor immunosuppressive therapy in a noninvasive, cost-effective manner. Biomarker research has focused on primary areas of kidney injury, the tubules and the cells that infiltrate them. This article reviews biomarkers currently under investigation in the setting of renal allograft transplantation.
Endothelial damage from intraocular lens insertion. (1976)

Previous studies have shown that approximately 40 per cent of the corneal endothelial cells can be lost at the time of intraocular lens insertion. Momentary contact between the methacrylate surface and the endothelial cells causes an adhesion between these surfaces and results in extensive cell damage upon separation of the surfaces. This type of damage appears to be due to a biophysical interaction between these surfaces and may be avoidable by altering the surface of the lens.
Nanomaterials for Wound Dressings: An Up-to-Date Overview (2020)

As wound healing continues to be a challenge for the medical field, wound management has become an essential factor for healthcare systems. Nanotechnology is a domain that could provide different new approaches concerning regenerative medicine. It is worth mentioning the importance of nanoparticles, which, when embedded in biomaterials, can induce specific properties that make them of interest in applications as materials for wound dressings. In the last years, nano research has taken steps to develop molecular engineering strategies for different self-assembling biocompatible nanoparticles. It is well-known that nanomaterials can improve burn treatment and also the delayed wound healing process. In this review, the first-line of bioactive nanomaterials-based dressing categories frequently applied in clinical practice, including semi-permeable films, semipermeable foam dressings, hydrogel dressings, hydrocolloid dressings, alginate dressings, non-adherent contact layer dressings, and multilayer dressings will be discussed. Additionally, this review will highlight the lack of high-quality evidence and the necessity for future advanced trials because current wound healing therapies generally fail to provide an excellent clinical outcome, either structurally or functionally. The use of nanomaterials in wound management represents a unique tool that can be specifically designed to closely reflect the underlying physiological processes in tissue repair.
Infertility (1989)

The difficulty may lie with the male partner, the female or both, although sometimes no cause can be found with our present methods of investigation and management (see Figure 18.1).
Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism (1991)

The pH dependence of the peptidolytic reaction of recombinant human immunodeficiency virus type 1 protease has been examined over a pH range of 3-7 for four oligopeptide substrates and two competitive inhibitors. The pK values obtained from the pKis vs pH profiles for the unprotonated and protonated active-site aspartyl groups, Asp-25 and Asp-25', in the monoprotonated enzyme form were 3.1 and 5.2, respectively. Profiles of log V/K vs pH for all four substrates were "bell-shaped" in which the pK values for the unprotonated and protonated aspartyl residues were 3.4-3.7 and 5.5-6.5, respectively. Profiles of log V vs pH for these substrates were "wave-shaped" in which V was shifted to a constant lower value upon protonation of a residue of pK = 4.2-5.2. These results indicate that substrates bind only to a form of HIV-1 protease in which one of the two catalytic aspartyl residues is protonated. Solvent kinetic isotope effects were measured over a pH (D) range of 3-7 for two oligopeptide substrates, Ac-Arg-Ala-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 and Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2. The pH-independent value for DV/K was 1.0 for both substrates, and DV = 1.5-1.7 and 2.2-3.2 at low and high pH (D), respectively. The attentuation of both V and DV at low pH (D) is consistent with a change in rate-limiting step from a chemical one at high pH (D) to one in which a product release step or an enzyme isomerization step becomes partly rate-limiting at low pH (D). Proton inventory data is in accord with the concerted transfer of two protons in the transition state of a rate-limiting chemical step in which the enzyme-bound amide hydrate adduct collapses to form the carboxylic acid and amine products.
Ameliorating effect of erythromycin on bleomycin‐induced pulmonary fibrosis: Role of alveolar macrophage activation and cytokine release (1997)

The objective of this study was to evaluate the effectiveness of erythromycin (EM) on bleomycin-induced pulmonary fibrosis in rats and its possible mechanisms. Seventy-five rats were divided into three groups. Alveolar macrophages (AM) were harvested through bronchalveolar lavage (BAL) and consecutive changes of tumour necrosis factor-alpha (TNF-alpha) and platelet-derived growth factor (PDGF) in AM supernatant and bronchoalveolar lavage fluid (BALF) were assayed with ELISA and bioassay, respectively. The AM-derived TNF-alpha was elevated on day 3, peaked day 7 and then decreased but remained at higher level until day 28. The AM-derived PDGF was increased on day 3, peaked on day 7 then decreased to non-statistically significant higher level. The TNF-alpha in BALF was increased significantly on day 3 then decreased to normal level; the peak preceded that of AM-derived TNF-alpha. The PDGF in BALF was increased on day 3, peaked on day 7, and then decreased to normal, which exhibited a consecutive change similar to that of AM-derived PDGF. The EM significantly suppressed TNF-alpha and PDGF release by AM, markedly decreased TNF-alpha and PDGF levels in BALF. The EM also lessened the collagen deposition, the lung hydroxyproline comprised 75.44%, 72.72% and 56.24% that of bleomycin-treated group on day 7, 14 and 28, respectively. In conclusion, EM can ameliorate bleomycin-induced pulmonary fibrosis possibly through suppression of TNF-alpha and PDGF as well as the inhibition on accumulation of inflammatory cells in the lung.
[Effect of alcohol extract of Cornus officinalis Sieb. et Zucc on GLUT4 expression in skeletal muscle in type 2 (non-insulin-dependent) diabetic mellitus rats]. (2001)

This experiment demonstrated that alcohol extract of Cornus officinalis Sieb. et Zucc can increase GLUT4 mRNA and its protein expression in NIDDM rats through promoting proliferation of islet and increasing postprandial secretion of insulin and therefore accelerate glucose transport.
Universal hepatitis A immunization recommendation made by ACIP (2005)

![Figure][1] 

Dr. Frenck 



On Oct. 26, 2005, the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC) voted unanimously to recommend universal immunization against hepatitis A in children 12 months to 35 months of age.

Note: ACIP votes
Single molecule studies of RNA polymerase II transcription in vitro (2014)

Eukaryotic mRNA transcription by RNA polymerase II (RNAP II) is the first step in gene expression and a key determinant of cellular regulation. Elucidating the mechanism by which RNAP II synthesizes RNA is therefore vital to determining how genes are controlled under diverse biological conditions. Significant advances in understanding RNAP II transcription have been achieved using classical biochemical and structural techniques; however, aspects of the transcription mechanism cannot be assessed using these approaches. The application of single-molecule techniques to study RNAP II transcription has provided new insight only obtainable by studying molecules in this complex system one at a time.
Functionalized Conducting Polymer Nanodots for Enhanced Cell Capturing: The Synergistic Effect of Capture Agents and Nanostructures (2011)

Nanostructured conducting polymer nanodots are prepared by electropolymerization of carboxylic acid group functionalized monomer in dichloromethane directly onto substrates. They demonstrate enhanced yields for the capture of tumor cells compared to smooth surfaces due to a synergistic effect of the capture agents and nanostructures. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Text Classification for Authorship Attribution Analysis (2013)

Authorship attribution mainly deals with undecided authorship of literary texts. Authorship attribution is useful in resolving issues like uncertain authorship, recognize authorship of unknown texts, spot plagiarism so on. Statistical methods can be used to set apart the approach of an author numerically. The basic methodologies that are made use in computational stylometry are word length, sentence length, vocabulary affluence, frequencies etc. Each author has an inborn style of writing, which is particular to himself. Statistical quantitative techniques can be used to differentiate the approach of an author in a numerical way. The problem can be broken down into three sub problems as author identification, author characterization and similarity detection. The steps involved are pre-processing, extracting features, classification and author identification. For this different classifiers can be used. Here fuzzy learning classifier and SVM are used. After author identification the SVM was found to have more accuracy than Fuzzy classifier. Later combined the classifiers to obtain a better accuracy when compared to individual SVM and fuzzy classifier.
Supportive Care Treatments for Toxicities of Anti-EGFR and Other Targeted Agents (2012)

Targeting of the epidermal growth factor receptor (egfr) pathway has become routine practice in the treatment of lung carcinoma. As more health authorities approve targeted compounds in a variety of treatment lines, use of this approach is expected only to increase.Gefitinib, an oral tyrosine kinase inhibitor (tki), is approved by Health Canada in the first-line setting of advanced non-small-cell lung carcinoma (nsclc) for tumours that harbour the EGFR gene mutation. Erlotinib, another tki, is currently approved in advanced nsclc in the second- and third-line settings.The side-effect profile of this class of drugs is unique. Hematologic toxicity is seldom seen. The most frequent side effects are rash and diarrhea. Although no randomized trials have addressed treatment of the side effects of this class of drugs, some basic principles of management have been agreed on and can likely improve patient compliance and decrease inappropriate dose reduction. The prognostic and predictive implications of side effects are also evolving.Finally, the ALK fusion mutation is being recognized as a mutation driver. The use of crizotinib (again, a tki) in this setting awaits approval. The side-effect profile of crizotinib is interesting and is also reviewed here.
Mercury and Health (2002)

Mercury, particularly methylmercury, is an established worldwide environmental pollutant with known toxicity in humans. The toxic effects of methylmercury in fish were first brought to light after several episodes of poisoning in Japan that involved a spectrum of adverse clinical outcomes. These ranged from paresthesias and blurred vision to more specific signs of methylmercury intoxication, such as concentric vision and deafness, and to coma and death in some cases. Pronounced deficits in neurologic development were also noted. These outcomes were associated with the ingestion of fish that contained methylmercury at levels of 10 ppm or higher — levels clearly linked . . .