gebhart/patrepeval huggingface dataset:
Using Complex Substitution Strategies for View Synchronization (1998)

Abstract Large-scale information systems typically contain autonomous information sources (ISs) that dynamically modify their content, interfaces as well as their query services regardless of the data warehouses (views) that are built on top of them. Current view technology fails to provide adaptation techniques for such changes giving support to only static views in the sense that views become undefined when ISs undergo capability changes. We propose to address this new view evolution problem - which we call view synchronization - by allowing view definitions to be dynamically evolved when they become undefined. The foundations of our approach to view synchronization include: the EvolvableSQL view definition language (E-SQL), the model for information source description (MISD), and the concept of legal view rewritings. In this paper, we now introduce the concept of the strongest synch-equivalent view definition that explicitly defines the evolution semantics associated with an E-SQL ...
A Non-Human Primate Model To Study Anti-HIV Gene Therapy Strategies. (2005)

Abstract AIDS remains a significant health problem worldwide despite the advent of highly active antiretroviral therapy (HAART). Although substantial efforts have been made to develop a vaccine there is still no cure and alternative strategies are needed to treat HIV infection and to control its spread. Our goal is to evaluate lenti and foamy retroviral vectors that inhibit HIV replication by RNA interference (RNAi) in a non-human primate SHIV model to develop a hematopoietic stem cell (HSC) gene therapy for AIDS. SHIV is a chimeric virus comprised of an SIV genome that contains the tat, rev and env genes of HIV and infects both T lymphocytes and macrophages. Infection of non-human primates with SHIV results in significant decreases in CD4+ T cells as early as 4 weeks post infection, and is currently the best large animal model available to test gene therapy strategies for AIDS. We are developing methylguanine-DNA-methyltransferase (MGMT) selection strategies for HSCs in the primate model to allow for high level marking with vectors containing anti-SHIV/HIV transgenes. We have obtained marking levels over 90% in granulocytes and over 30% in lymphocytes. To determine the effectiveness of an anti tat/rev shRNA to inhibit SHIV in vitro, a human T cell/B cell hybrid cell line (CEMx174) was transduced with a lentiviral vector expressing a short-hairpin RNA (shRNA) targeted to both HIV tat and rev sequences that also contained either a GFP reporter gene or a MGMT(G156A) resistance gene. Polyclonal populations of CEMx174 cells transduced with the GFP and MGMT(G156A) vectors were challenged with a 2.15x103 TCID50 dose of SHIV. Expression of both tat and rev transcripts was reduced 88% and 97% respectively in these cultures as measured by real-time PCR and replication of SHIV was inhibited as evidenced by inhibition of p27 production. Although others reported a block to transduction of M. mulatta CD34+ cells with an HIV-based lentiviral vector, we observed efficient transduction rates (~45%) of M. nemestrina CD34+ cells, comparable to transduction rates observed in human CD34+ cells (~55%). Thus M. nemestrina monkeys provide a powerful model to test lenti and foamy virus mediated anti-HIV gene therapy strategies.
<title>Defect mechanism of photoinduced superconductivity in YYBa<formula><inf><roman>2</roman></inf></formula>Cu<formula><inf><roman>3</roman></inf></formula>O<formula><inf><roman>x</roman></inf></formula></title> (1996)

Persistent photoconductivity and photoinduced superconductivity have been previously observed in various stoichiometries of YBa<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>x</SUB>. The physical mechanism which is responsible for these effects is still under debate. Through an investigation of laser ablated YBa<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>x</SUB> thin film compositions, photoluminescence spectra and infrared spectroscopy, the possibility that the mechanism may be defect related has been supported. A correlation between photoluminescence spectra and wavelength dependence support an oxygen defect model of photoinduced persistent conductivity and superconductivity in which the oxygen vacancies act as weakly luminescent F-centers and F<SUP>+</SUP>-centers under illumination. Upon infrared illumination the trapped electrons are photoexcited resulting in a partial quenching of the persistent photoconductivity state.
Genetic Breast Cancer Susceptibility Variants and Prognosis in the Prospectively Randomized SUCCESS A Study (2017)

Large-scale genotyping studies have identified over 70 single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. However, knowledge regarding genetic risk factors associated with the prognosis is limited. The aim of this study was therefore to investigate the prognostic effect of nine known breast cancer risk SNPs. BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> . Cox proportional hazards models were used to test the SNPs' association with overall survival (OS) and progression-free survival (PFS). Additional analyses were carried out for molecular subgroups. rs3817198 in <i>LSP1</i> (lymphocyte-specific protein 1) was the only SNP that significantly influenced OS (p = 0.01) and PFS (p < 0.01) in the likelihood ratio test comparing the genetic survival model with the clinical survival model. In the molecular subgroups, triple-negative patients with two minor alleles in rs3817198 had a much better prognosis relative to OS (adjusted HR 0.03; 95% CI 0.002 - 0.279) and PFS (HR 0.09; 95% CI 0.02 - 0.36) than patients with the common alleles. The same effect on PFS was shown for patients with luminal A tumors (HR 0.19; 95% CI 0.05 - 0.84), whereas patients with luminal B tumors had a poorer PFS with two minor alleles (HR 2.13; 95% CI 1.02 - 4.40). The variant in rs3817198 has a prognostic effect particularly in the subgroup of patients with triple-negative BC, suggesting a possible link with immunomodulation and BC.
A Facile Method for the Synthesis of Cleavable Block Copolymers from ATRP-Based Homopolymers (2007)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTA Facile Method for the Synthesis of Cleavable Block Copolymers from ATRP-Based HomopolymersAkamol Klaikherd, Suhrit Ghosh, and S. ThayumanavanView Author Information Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003 Cite this: Macromolecules 2007, 40, 24, 8518–8520Publication Date (Web):October 24, 2007Publication History Received16 August 2007Revised2 October 2007Published online24 October 2007Published inissue 1 November 2007https://pubs.acs.org/doi/10.1021/ma071852nhttps://doi.org/10.1021/ma071852nrapid-communicationACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views2757Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymers,Gel permeation chromatography,Homopolymers,Mixtures,Polymers Get e-Alerts
Tetrahexahedral Pt Nanocrystal Catalysts Decorated with Ru Adatoms and Their Enhanced Activity in Methanol Electrooxidation (2012)

Tetrahexahedral Pt nanocrystals (THH Pt NCs) bound by well-defined high index crystal planes offer exceptional electrocatalytic activity, owing to a high density of low-coordination surface Pt sites. We report, herein, on methanol electrooxidation at THH Pt NC electrodes studied by a combination of electrochemical techniques and in situ FTIR spectroscopy. Pure THH Pt NC surfaces readily facilitate the dissociative chemisorption of methanol leading to poisoning by strongly adsorbed CO. Decoration of the stepped surfaces by Ru adatoms increases the tolerance to poisoning and thereby reduces the onset potential for methanol oxidation by over 100 mV. The Ru modified THH Pt NCs exhibit greatly superior catalytic currents and CO2 yields in the low potential range, when compared with a commercial PtRu alloy nanoparticle catalyst. These results are of fundamental importance in terms of model nanoparticle electrocatalytic systems of stepped surfaces and also have practical significance in the development of surface tailored, direct methanol fuel cell catalysts.
SORL1 is Genetically Associated with Neuropathologically Characterized Late-Onset Alzheimer's Disease (2013)

SORL1 was shown to be genetically associated with late-onset Alzheimer's disease (LOAD) in a large-scale genome-wide association study (GWAS) involving clinically verified subjects. Here, we attempted to replicate the association of SORL1 in Japanese neuropathologically characterized brain donor subjects (LOAD, 213; control, 370) through a single-nucleotide polymorphism (SNP)-based genetic study involving 19 SNPs: 11 SNPs were selected from the initial study reported by Rogaeva et al. (2007), and the other eight were from our GWAS. Among these SNPs, five exhibited a significant association with LOAD after multiple test correction (p < 2.63E-03 [ = 0.05/19]), which was supported by means of multiple logistic regression analysis with adjustment for age, gender, and carrier status of the APOE ε4 allele. Three of these SNPs (rs985421, rs12364988 [Rogaeva's SNP 7], and rs4598682) were encompassed by a 5' linkage disequilibrium (LD) region, and the remaining two (rs3781834 and rs3781836) by a 3' LD region. Strong LD among SNPs was observed within each LD region, implying that there are two genomic regions showing association with LOAD in SORL1. Case-control haplotype analysis demonstrated that some haplotypes are associated with LOAD in both LD regions. Our replication study strongly supports the preceding evidence that SORL1 is likely one of the genes associated with LOAD.
Frequency Dependence of Coda Q, Part I: Numerical Modeling and Examples from Peaceful Nuclear Explosions (2008)

Frequency-dependent coda attenuation values are often reported; however, such measurements usually depend on the types of the Q ( f ) models employed. We use numerical modeling of peaceful nuclear explosion (PNE) coda at far-regional to teleseismic distances to compare two such models, namely, the conventional frequency-dependent quality factor ( Q coda( f )= Q f η ) and frequency-independent coda attenuation ( Q c ) with geometrical attenuation ( γ ). The results favor strongly the ( γ , Q c ) model and illustrate the mechanisms leading to apparent Q coda( f ) dependencies. Tests for variations of the crustal velocity structures show that the values of γ are stable and related to lithospheric structural types, and the inverted Q c -values can be systematically mapped into the true S -wave attenuation factors within the crust. Modeling also shows that γ could increase in areas where relatively thin attenuating layers are present within the crust; such areas could likely be related to younger and active tectonics. By contrast, when interpreted by using the traditional ( Q , η ) approach, the synthetic coda shows a strong and spurious frequency dependence with η ≈0.5, which is also similar to the observations.

Observed Lg coda from two PNEs located in different areas in Russia show similar values of γ ≈0.75×10-2 sec-1, which are also remarkably close to the independent numerical predictions. At the same time, coda Q c -values vary strongly, from 850 in the East-European platform to 2500 within the Siberian Craton. This suggests that parameters γ and Q c could provide stable and transportable discriminants for differentiating between the lithospheric tectonic types and ages and also for seismic coda regionalization in nuclear test monitoring research.
Rapid thermal nitridation of thin thermal silicon dioxide films (1985)

The electrical characteristics of thin nitrided thermal silicon dioxide films prepared by a new rapid thermal process are described. This process is performed in a controlled gas ambient under an incoherent photon flux with a duration typically less than 60 s. It allows the incorporation of a controlled nitride layer in the bulk (oxinitride), on the surface, or at the silicon interface of the oxide. Gate dielectrics with superior electrical and chemical properties have been obtained. Applications in metal-oxide-semiconductor integrated circuit technologies are suggested.
ChemInform Abstract: N‐Acyl‐N′‐methyl‐N‐(1,3,5‐trimethylbicyclo(2.2.1)hept‐2‐yl)benzamidines with Hypotensive Activity. (1988)

Abstract The benzamidine derivatives (IV) mentioned in the title are prepared by LiAlH 4 reduction of the N'‐(phenoxycarbonyl)benzamidine (I), followed by acylation of the resulting amidine (II).
Analysis of Barkhausen Noise Emissions and Magnetic Hysteresis in Multi-Phase Magnetic Materials (2014)

Ferromagnetic materials occur in single or multi-phase state and furthermore can undergo phase changes during processing or over time during service exposure. These phase changes can be attributed to physical processes or chemical reactions. In this paper, we examine the hysteresis and Barkhausen emission profiles of two-phase magnetic materials. Besides the shape of magnetic hysteresis curves that can reveal the presence of more than one phase, we demonstrate that the Barkhausen noise signatures for two-phase materials form two-peaks in their Barkhausen voltage profile. This can be used as a tool for non-destructive evaluation of ferromagnetic materials in industrial applications.
V3-Specific Polyclonal Antibodies Affinity Purified from Sera of Infected Humans Effectively Neutralize Primary Isolates of Human Immunodeficiency Virus Type 1 (2001)

Although many human sera possess potent neutralizing activities for primary HIV-1 viruses, such activities are not efficiently induced by the current generation of vaccine candidates, and the epitopes mediating this neutralization are not known. The V3 loop of gp120 is believed to be the principal neutralization domain of laboratory-adapted viruses, but the importance of this region in neutralization of primary isolates is unclear. This question was explored using polyclonal anti-V3 antibodies purified by immunoaffinity methods from sera of HIV-1-infected patients. To include antibodies that might be directed against conformational and/or glycan-dependent epitopes not presented by synthetic peptides, the antibody isolations were performed with a fusion glycoprotein expressing the native V3 region of JR-CSF, a primary R5 isolate. V3-reactive antibody fractions from all eight sera examined showed potent neutralization of at least one of the three primary HIV-1 isolates tested; four of these antibody preparations neutralized all three primary viruses. For a number of serum-virus combinations 90% neutralization doses (ND(90)) between 1 and 5 microg/ml were obtained, and the most potent anti-V3 fraction had ND(50) values at or below 0.3 microg/ml for all three primary isolates. These neutralization activities against primary viruses were higher than those of potent monoclonal antibodies assayed in the same experiment. These data indicate that the V3 region can be an important neutralization target in primary isolates, and suggest that effective presentation of V3 epitopes in a vaccine formulation might induce protective humoral responses against natural infection by HIV-1.
Antigenic Heterogeneity of Skin Tumors of Nonmelanocyte Origin: Analysis With Monoclonal Antibodies to Tumor-Associated Antigens and to Histocompatibility Antigens<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref> (1983)

Surgically removed benign and malignant human skin lesions of nonmelanocyte origin have been tested with monoclonal antibodies to la antigens, to the HLA-A,B antigenic molecular complex, and to melanoma-associated antigen(s) (MAA). MAA include a high-molecular-weight (HMW) MAA, a 115,000-molecular-weight MAA, a 94,000-molecular-weight MAA, and a cytoplasmic MAA. Indirect immunofluorescence was used as the assay system because of the limited amount of tissue available. When the amount of tissue available was sufficient, double determinant immunoassays (DDIA) were used to quantitate the level of the HMW MAA and of the cytoplasmic MAA. The results of the DDIA were in agreement with those of indirect immunofluorescence in more than 75% of the cases. Malignant skin tumors of various histiotypes displayed three types of changes: 1) appearance of la antigens and cytoplasmic MAA, 2) increase in the level of the HMW MAA, of a 115,000- and a 100,000-molecular-weight MAA, and 3) reduction in the level of HLA-A,B antigens and beta 2-microglobulin. A significant heterogeneity was found in the antigenic profile among various lesions of a given histiotype as well as among tumor cells within a given lesion.
The Charge‐Reverse Analogy as an Inspiration for the Preparation of Polydentate Lewis Acidic Boranes (2003)

Reversing the charge: The recent preparation of a masked version of a 2,2′-diborabiphenyl (the radical anion of its adduct with benzo[c]cinnoline is shown) constitutes a noticeable achievement on the way to bidentate Lewis acidic boranes with optimized properties as ligands and opens up the chemistry of this unique class of bidentate Lewis acids.
ChemInform Abstract: A Novel Approach Toward the Synthesis of Chiral 2,3‐Dideoxy Nucleosides and Their Carbocyclic Analogues. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MnO Conversion in Li-Ion Batteries: In Situ Studies and the Role of Mesostructuring (2016)

Complex manganese oxides have been extensively studied as intercalation Li-ion battery electrodes. The simple oxide MnO has been proposed as a conversion anode material with a theoretical capacity of 756 mAh g(-1) for full reduction to the metal. We report the reaction of MnO with Li using in situ X-ray diffraction and find no sign of crystalline products upon either discharge or charge. However, the absence of reflections, paired with electrochemical impedance spectroscopy, suggests disordered discharge products. We also examine composite electrodes with porous particles of MnO as the active component, with pores generated through the reductive heating of Mn3O4. We compare the behavior of these with more dense MnO powders, including studies of the electrode morphologies pre- and postcyling. We find differences in the first discharge relevant to the utility of such mesostructuring in conversion reaction materials. Specifically, we find this type of mesostructure, which gives advantage in intercalation and pseudocapacitive storage, does not yield the same benefits for conversion reaction systems.
ChemInform Abstract: Identification of Peptide Oxidation by Tandem Mass Spectrometry (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Al‐Mn μ phase and its relation to quasicrystals (1987)

SUMMARY The potential interrelationship between the Al‐Mn μ phase and icosahedral structures is investigated by a systematic study of the electron diffraction behaviour of the crystalline phase. The presence of systematic absences in selected area diffraction patterns is used to propose a space group for the μ phase and similarities with the icosahedral and decagonal diffraction patterns are argued to imply the presence in both the crystalline and quasicrystalline phases of icosahedral units with different stacking arrangements.
<title>Signal-To-Noise Ratio Improvement Of Analog Pulse-Position Modulation Over Analog Intensity Modulation In Optical Communication Links</title> (1975)

This paper presents a comparison of the performance of optical communication links employing analog pulse-position modulation and analog intensity modulation. In particular, the theoretical output signal-to-noise ratios for the two types of modulation are compared assuming "equivalent" optical links. Analog pulse-position modulation offers signal-to-noise ratio improvement over intensity modulation at the expense of increased system complexity and expanded transmission band-width. The effect of timing errors on the signal-to-noise ratio of the pulse-position modulation receiver is considered, and it is shown that these errors can degrade performance significantly from theoretical .
Sensing Remote Chirality: Stereochemical Determination of β‐, γ‐, and δ‐Chiral Carboxylic Acids (2015)

Determining the absolute stereochemisty of small molecules bearing remote nonfunctionalizable stereocenters is a challenging task. Presented is a solution in which appropriately substituted bis(porphyrin) tweezers are used. Complexation of a suitably derivatized β-, γ-, or δ-chiral carboxylic acid to the tweezer induces a predictable helicity of the bis(porphyrin), which is detected as a bisignate Cotton Effect (ECCD). The sign of the ECCD curve is correlated with the absolute stereochemistry of the substrate based on the derived working mnemonics in a predictable manner.
THz communication system based on a THz Quantum Cascade Laser and a Hot Electron Bolometer (2010)

We present the experimental study of the direct emission - detection system based on the THz Quantum Cascade Laser as a source and Hot Electron Bolometer (HEB) detector - in view of its application as an optical communication system. We show that the system can efficiently transmit the QCL Terahertz pulses. We estimate the maximal modulation speed of the system to be about several GHz and show that it is limited only by the QCL pulse power supply, detector amplifier and connection line/wires parameters.
Towards a unified low frequency Stability criterion for 15 kV / 16.7 Hz and 25 kV / 50 Hz railway power system (2020)

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