gebhart/patrepeval huggingface dataset:
Effect of Early Corticosteroid Therapy for Landau‐Kleffner Syndrome (1991)

SUMMARY Four children treated for seizures between 1980 and 1986 were diagnosed as having Landau‐Kleffner syndrome (acquired aphasia with convulsive disorder), following the onset of aphasia. They received early and prolonged ACTH or corticosteroid therapy, with high initial doses. In all four cases the EEG promptly became normal, with subsequent long‐lasting remission of the aphasia and improvement of seizure control. Three to six years after discontinuation of hormone therapy the children are off medication and free from seizures and language disability. RÉSUMÉ Effets du traitement précoce par corticostéroïdes dans le syndrome de Landay‐Kleffner Un diagnostic de syndrome de Landau‐Kleffner (aphasie acquise et convulsions) a été porté chez quatre enfants traités pour crises comitiales entre 1980 et 1986, à la suite du diagnostic d'aphasie. Ces enfants reçurent un traitment précoce et prolongé par ACTH ou corticostéroïdes, avec des doses initiales élévees. Dans les quatre cas, l'EEG fut rapidement normalisé, avec une rémission ultérieure de longue durée de l'aphasie et amélioration du controle des crises. Trois à six ans après la cessation du traitement hormonal, les enfants sont sans traitement, sans crises ni troubles de langage. ZUSAMMENFASSUNG Die Wirkumg frühzeitiger Corticoidtherapie beim Landau‐Kleffner Syndrom Bei vier Kindern, die in den Jahren 1980 bis 1986 wegen Krampfanfällen behandelt wurden, wurde mit dem Auftreten einer Aphasie die Diagnose Landau‐Kleffner Syndrome (erworbene Aphasie mit Krampfleiden) gestellt. Sie bekamen frühzeitig und über längere Zeit ACTH oder Corticoide in hoher Anfangsdosis. In allen vier Fällen normalisierte sich das EEG sofort, und es folgte eine anhaltende Remission der Aphasie und eine bessere Anfallskontrolle. Drei bis sechs Jahre nach dem Absetzen der Hormontherapie sind die Kinder ohne Medikamente, anfallsfrei und ohne Sprachbehinderung. RESUMEN El efecto de la terapia precoz con corticosteroides en el sindrome de Landau‐Kleffner Cuatro niños tratados por convulsiones entre 1980 y 1986 fueron diagnosticados de sindrome de Landau‐Kleffner (afasia adquirida con alteración convulsiva) a consecuencia del inicio de una afasia. Recíbieron una terapia precoz y prolongada con ACTH o con corticoides con dosis iniciales altas. En los cuatro casos el EEG se normalizó rápidamente con una remisión posterior de larga duración de la afasia y mejoría en el control de las convulsiones. Tres y seis años después de interrumpir la hormonoterapia los niños no toman ninguna medicación y estan libres de convulsiones y alteraciones en el lenguaje.
Pertussis on the rise (1994)

The number of pertussis cases reported to the U.S. Centers for Disease Control and Prevention (CDC) increased 82 percent from 1992 to 1993, according to a study in the Dec. 17 Morbidity and Mortality Weekly Report (MMWR) . CDC received reports of 5,457 pertussis cases between Jan. 3 and Dec. 4, 1993, compared to 3,004 cases in 1992. The figures represent the highest annual number of cases reported since 1967, according to the study. Reported cases increased most in New England, the Mid-Atlantic, North Central and Mountain regions, with large pertussis outbreaks occurring in Chicago and Cincinnati, researchers stated.
In-Frame Cloning of Synthetic Genes Using PCR Inserts (2003)

Because many genes of biological interest are larger than the maximum size that current synthetic oligonucleotide synthesizers can produce (approx 110 bases), there is a need for methods that allow rapid production and expression of genes constructed from multiple synthetic DNA fragments. A number of synthetic genes have been generated using the recursive polymerase chain reaction (PCR) method, but problems concerning primer design and incorrect final gene sequence, especially with large synthetic genes, are a concern (-). The cloning method described here follows a series of steps in which multiple PCR products or synthetic duplex oligonucleotides are positionally cloned into a plasmid vector (). A synthetic gene of practically any sequence or length can be built using the in-frame cloning method. Genes are assembled such that open reading frames are maintained by linking DNA fragments through the use of six basepair blunt-end restriction sites. Each cloning step uses an anchored sticky-end restriction site and a variable blunt-end restriction site that result in specific insert orientation and high cloning efficiencies. The overall strategy of in-frame cloning allows the researcher total control over nucleotide sequence, codon usage, promoter and other regulatory elements, and the placement of unique restriction sites throughout the recombinant construct. One advantage of the in-frame cloning method described here is that it allows for flexible yet precise construction of synthetic genes using standard recombinant techniques. Another advantage is that it employs inexpensive, readily available materials.
Use of nonrotational aspherical surfaces in optical systems (1985)

From the time of the Herschelian telescope, optical scientists have recognized that use can sometimes be made of decentered, nonrotational optical surfaces to achieve limited advantages and often practical convenience. Enough background is given to clarify recent applications of generalized nonrotational surfaces to permit convenient focusing and power changes in small cameras. In particular, attention is given to design controls that permit utilization of deformed surfaces over increased apertures and fields of view. Advances in the state of the art are discussed and attention given to limitations presently encountered.
Design of Monitor and Protect Circuits against FIB Attack on Chip Security (2012)

As information security chips are more widely used in the field of information security, the security of chips becomes increasingly important, which has also been a hot research field of information security. With the advances in technology, a chip-invasive method of attack which uses laser or focused ion beam (FIB) to change the chip's internal signal line, and then probe the chip's secret information with the electron microprobe, becomes a serious threat to information security chip. Such an attack makes the shielding metal wire an effective mean to improve chip security. The protection circuit module monitoring the shielding metal line is to ensure the layer of the metal wire is undamaged, in order to ensure that the chip has not been attacked by laser or FIB. This paper studies the design and implementation of Monitor and Protect Circuits (MPC) based on RC delay, which monitor if the shielding metal wires are damaged. The circuit is designed in SMIC0.18um CMOS process and an entire layout is completed. The gate count of MPC is about 642, which is 2.9% of that of AES. And its power consumption is about 81uw.
Lipoprotein-Associated Phospholipase A <sub>2</sub> and C-Reactive Protein for Risk-Stratification of Patients With TIA (2009)

Many patients with TIA have a high-risk mechanism (large vessel stenosis or cardioembolism) or will experience stroke/death within 90 days. In contrast to CRP, both Lp-PLA(2) mass and activity were associated with this composite end point, and LpPLA(2)-A appears to provide additional prognostic information beyond the ABCD(2) clinical risk score alone.
A brief history of thermophotovoltaic development (2003)

This history begins with the uncertain location and time of the invention of the thermophotovoltaic (TPV) energy conversion technology. The early contributors to the technology include universities, government laboratories, and industrial research organizations when substantial development occurred in the 1960s. The energy crises of the 1970s caused a shift in emphasis from fossil-fueled power generation to solar energy conversion. The recent contributors to the technology are identified as TPV has experienced a revival since the early 1990s.
Light and electron microscopic studies on the localization of hyaluronic acid in developing rat cerebellum. (1988)

The hyaluronic acid-binding region was prepared by trypsin digestion of chondroitin sulfate proteoglycan aggregate from the Swarm rat chondrosarcoma, and biotinylated in the presence of hyaluronic acid and link protein. After isolation by gel filtration and HPLC in 4 M guanidine HCl, the biotinylated hyaluronic acid-binding region was used, in conjunction with avidin-peroxidase, as a specific probe for the light and electron microscopic localization of hyaluronic acid in developing and mature rat cerebellum. At 1 w postnatal, there is strong staining of extracellular hyaluronic acid in the presumptive white matter, in the internal granule cell layer, and as a dense band at the base of the molecular layer, surrounding the parallel fibers. This staining moves progressively towards the pial surface during the second postnatal week, and extracellular staining remains predominant through postnatal week three. In adult brain, there is no significant extracellular staining of hyaluronic acid, which is most apparent in the granule cell cytoplasm, and intra-axonally in parallel fibers and some myelinated axons. The white matter is also unstained in adult brain, and no staining was seen in Purkinje cell bodies or dendrites at any age. The localization of hyaluronic acid and its developmental changes are very similar to that previously found in immunocytochemical studies of the chondroitin sulfate proteoglycan in nervous tissue (Aquino, D. A., R. U. Margolis, and R. K. Margolis. 1984. J. Cell Biol. 99:1117-1129; Aquino, D. A., R. U. Margolis, and R. K. Margolis. J. Cell Biol. 99:1130-1139), and to recent results from studies using monoclonal antibodies to the hyaluronic acid-binding region and link protein. The presence of brain hyaluronic acid in the form of aggregates with chondroitin sulfate proteoglycans would be consistent with their similar localizations and coordinate developmental changes.
Transparency, ultraviolet transmittance, and miscibility of poly(lactic acid)/poly(methyl methacrylate) blends (2017)

Poly(lactic acid)/poly(methyl methacrylate) (PLA/PMMA) blends were prepared by melt compounding technique. The miscibility of PLA/PMMA blends at various blending ratios (i.e. 80/20, 60/40, 40/60, and 20/80) was investigated using a dynamic mechanical analyzer (DMA) and solvent uptake experiment. The solvent uptake experiment was conducted to estimate the interaction of PLA/PMMA blends based on the calculation of Flory–Huggins interaction parameter ( χ 12 ). DMA results revealed that only single glass transition temperature ( T g ) existed along the PLA/PMMA blends. Smallest χ 12 (i.e. −0.03) was found on the PLA/PMMA20 blend, suggesting interaction between PLA and PMMA at this composition. The incorporation of PMMA slightly improved the UV protection properties of the PLA/PMMA blend, while maintaining their optical transparency.
Ontological approach for the semantic recovery of traceability links between software artefacts (2008)

Traceability links provide support for software engineers in understanding relations and dependencies among software artefacts created during the software development process. The authors focus on re-establishing traceability links between existing source code and documentation to support software maintenance. They present a novel approach that addresses this issue by creating formal ontological representations for both documentation and source code artefacts. Their approach recovers traceability links at the semantic level, utilising structural and semantic information found in various software artefacts. These linked ontologies are supported by ontology reasoners to allow the inference of implicit relations among these software artefacts.
Improving managerial decision making: the case of a hospital laboratory. (1987)

Attempting to reduce costs, a hospital laboratory replaced its continuous flow analyzer, which performs 20 tests at once with a discrete analyzer able to perform a combination of the 20 tests. In order for this change to result in actual cost savings, physicians had to reduce their utilization of the laboratory. The laboratory administrators, however, assumed that the required test reduction could be realized. This assumption proved to be incorrect. Physicians continued to order a large number of tests per sample (e.g., 14). As a result of this incorrect decision laboratory costs increased by $124,200 per year. These results highlight the need to test the accuracy of managerial decision-making assumptions. The ease and low cost of conducting pilot studies to test the validity of such assumptions dictates that administrators insist that they be conducted before managerial strategies are implemented.
Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis (2020)

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-related death. Metastatic disease or the movement of cancer cells from one site to another requires dramatic remodeling of the cytoskeleton. The regulation of cancer cell migration is determined not only by biochemical factors in the microenvironment but also by the biomechanical contextual information provided by the extracellular matrix (ECM). The responses of the cytoskeleton to chemical signals are well characterized and understood. However, the mechanisms of response to mechanical signals in the form of externally applied force and forces generated by the ECM are still poorly understood. Furthermore, understanding the way cellular mechanosensors interact with the physical properties of the microenvironment and transmit the signals to activate the cytoskeletal movements may help identify an effective strategy for the treatment of cancer. Here, we will discuss the role of tumor microenvironment during cancer metastasis and how physical forces remodel the cytoskeleton through mechanosensing and transduction.
Fluorescent Imaging With Indocyanine Green During Laparoscopic Cholecystectomy in Patients at Increased Risk of Bile Duct Injury (2017)

Early visualization of the CD or additional identification of the CBD using ICG-NIR in patients with complicated cholecystolithiasis can be helpful in preventing CBD injury. Future studies should attempt to establish the optimal dosage and time frame for ICG administration and bile duct visualization with respect to different gallbladder pathologies.
Digital color classification for colorful cross stitch threads using RGB+Euclidean Distance and LAB+CIE94 (2016)

This paper presents an approach of converting a digital image to a cross stitch pattern. The color space of the input image is quantized and classified into the nearest thread colors using k-NN classifier. Two different metrics are tested, i.e. CIE94 (which using LAB color space) and Euclidean Distance (which using RGB color space). The outputs are validated both quantitatively (using Color Coherent Vector/ CCV) and qualitatively (through human perception). The results have shown that CIE94 works best for grayscale and monochrome patterns, while Euclidean distance is more suitable for color patterns.
Effect of Low Cobalt Loading on TiO<sub>2</sub>Nanotube Arrays for Water-Splitting (2014)

This work is intended to define a new possible methodology for the TiO 2 doping through the use of an electrochemical deposition of cobalt directly on the titanium nanotubes obtained by a previous galvanostatic anodization treatment in an ethylene glycol solution. This method does not seem to cause any influence on the nanotube structure, showing final products with news and interesting features with respect to the unmodified sample. Together with an unmodified photoconversion efficiency under UV light, the cobalt doped specimen reports an increase of the electrocatalytic efficiency for the oxygen evolution reaction ( OER ).
Microfabrication of High Resolution X-ray Magnetic Calorimeters (2009)

Metallic magnetic calorimeter (MMC) is one of the most promising x‐ray detector technologies for providing the very high energy resolution needed for future astronomical x‐ray imaging spectroscopy. For this purpose, we have developed micro‐fabricated 5×5 arrays of MMC of which each individual pixel has excellent energy resolution as good as 3.4 eV at 6 keV x‐ray. Here we report on the fabrication techniques developed to achieve good resolution and high efficiency. These include: processing of a thin insulation layer for strong magnetic coupling between the AuEr sensor film and the niobium pick‐up coil; production of overhanging absorbers for enhanced efficiency of x‐ray absorption; fabrication on SiN membranes to minimize the effects on energy resolution from athermal phonon loss. We have also improved the deposition of the magnetic sensor film such that the film magnetization is nearly completely that is expected from the AuEr sputter target bulk material. In addition, we have included a study of a positional sensitive design, the Hydra design, which allows thermal coupling of four absorbers to a common MMC sensor and circuit.
Epidemiology of Permanent Childhood Hearing Impairment in Trent Region, 1985–1993 (1997)

This retrospective study of permanent childhood hearing impairment (PCHI) > or = 40 dB HL in children born between 1985 and 1993 and resident in Trent Health Region, achieved an ascertainment of 92.9% of that expected from previous studies and 100% for the subset of children born between 1985 and 1990. The prevalence rate of all permanent hearing impairment > or = 40 dB HL for the birth cohort 1985-90 is 133 (95% confidence interval, (ci) 122-145) per 100,000 live births (1 in 750). Sixteen per cent of PCHI were postnatally acquired, late-onset or progressive impairments. Excluding these, the prevalence rate for congenital impairments is 112 (ci 101-123) per 100,000 (1 in 900). The rate for profound impairments > or = 95 dB HL is 24 (ci 20-30) per 100,000 live births (1 in 4150). Prevalence was increased sixfold for children with a history of neonatal intensive care and 14-fold for children with a family history, compared with children with no risk factors. A more than two-fold increase in prevalence was seen in Asian children. For the congenitally-impaired children born between 1985 and 1990, 29% had a stay in neonatal intensive care > or = 48 hours, 30% had a family history of permanent childhood hearing impairment, and 12% had a cranio-facial abnormality (CFA). Over 59% were potentially detectable by a targeted neonatal screening programme using these three high-risk factors. For 1985-1993, the overall yield of the targeted neonatal screening programmes available in three of the 11 health districts was 15% but increased over time. The overall yield from the Health Visitor distraction test was 30% but lower in districts with neonatal screening programmes. Only 59% of children had a stated aetiology, classified by time of onset into genetic, including syndromes and CFA (41%), pre- or peri-natal (10%), post-natally acquired (6%), and uncertain onset (2%). Just under 40% of the children were said to have another clinical or developmental problem, about half of whom had at least two additional problems. The median age at referral, confirmation of the impairment, prescription of the hearing aid and fitting of the hearing aid were, respectively, 10.4 months, 18.1 months, 24.4 months and 26.3 months. A more severe impairment was associated with earlier age. Small improvements in the median age of hearing aid prescription and fitting were seen over time. Twenty-five per cent of children were referred for genetic counselling, the proportion increasing systematically with the severity of the impairment. Based on evidence of the yield from hearing screens we suggest a wider implementation of neonatal screening and further consideration of the role of the health visitor distraction test in the identification of children with PCHI. To facilitate further assessment of services for hearing-impaired children we suggest implementation of a co-ordinated shared list of children with permanent hearing impairment on a region-wide basis to provide adequate numbers for comparison over time, and the routine collection of a minimum set of data for each child.
LOST AND REGAIN'D (1967)

Journal Article LOST AND REGAIN'D Get access F. T. PRINCE F. T. PRINCE Southampton Search for other works by this author on: Oxford Academic Google Scholar Forum for Modern Language Studies, Volume III, Issue 3, July 1967, Pages 310–314, https://doi.org/10.1093/fmls/III.3.310 Published: 01 July 1967
The characteristic function of Hermitian quadratic forms in complex normal variables (1960)

The characteristic function of Hermitian quadratic forms in complex normal variables G. L. TURIN G. L. TURIN Hughes Research LaboratoriesCulver City, California Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 47, Issue 1-2, June 1960, Pages 199–201, https://doi.org/10.1093/biomet/47.1-2.199 Published: 01 June 1960
Introduction to Electronic Warfare (1986)

This book clearly describes all the radar detection and jamming equations you need to design and analyze search and track radars. It reviews the hardware, theories, and techniques involved in modern EW systems signal processing and discusses present and future trends in EW technology.
Tratamiento simultáneo de estenosis valvular pulmonar y persistencia del conducto arterioso mediante cateterismo percutáneo (2003)

Introduction. Patent ductus arteriosus and pulmonary valve stenosis are among the most frequent congenital heart malfomation, although their association is uncommon. Both lesions can be simultaneously corrected in a single catheterization session. Case report. A 33 months old female was referred to our Hospital because an asymptomatic cardiac murmur. On admission her weight was 13 kg, height 90 cm, and a III/VI protosystolic cardiac murmur was found. Dilatation of the main pulmonary artery and normal lung flow were present on a chest X ray examination, and right ventricular hyperthrophy in EKG. Situs solitus, thickened pulmonary valve, patent ductus arteriosus, and left to right shunt were disclosed in an echocardiogram. The pulmonary valve stenosis was managed through catheterization using a valvuloplasty balloon, and the patent ductus arteriosus was closed with a coil in the same session. The patient was discharged well, 6 hours after the procedure. Conclusion. This case exemplifies that interventional cardiac catheterization is currently an excellent alternative in selected cases; its morbidity is minimal and usually can be performed on an ambulatory basis and simultaneous treatment of a combinations of lesions is feasible in some patients.