gebhart/patrepeval huggingface dataset:
SILMUT: a computer program for the identification of regions suitable for silent mutagenesis to introduce restriction enzyme recognition sequences. (1992)

We describe a set of IBM-compatible computer programs designed to selectively identify the potential sites for silent mutagenesis within a target DNA sequence. This program is based on a novel strategy of identifying amino acid motifs compatible with each restriction site (BioTechniques 12:382-384, 1991). The programs can be used to identify the suitability for the introduction of any 6-base nucleic acid sequences, such as restriction enzyme sites in cassette mutagenesis strategies. The Table program generates a table of multiple amino acid motifs for each restriction enzyme, obtained by translating each unique recognition sequence in all three reading frames. The Silmut program, which utilizes the features of Table, will further identify the presence of a match between any amino acid motif of each restriction enzyme and the input target sequence. Minor manipulations of the data base files will enable the individual researcher to identify the potential for introduction of any 6-base sequences by silent mutagenesis.
Mechanisms of Recombination: Lessons from<i>E. coli</i> (2008)

The genetics and biochemistry of genetic recombination in E. coli has been studied for over four decades and provides a useful model system to understand recombination in other organisms. Here we provide an overview of the mechanisms of recombination and how such processes contribute to DNA repair. We describe the E. coli functions that are known to contribute to these mechanisms, step by step, and summarize their biochemical properties in relation to the role these proteins play in vivo. We feature areas of investigation that are newly emerging, as well as work that provides a historical perspective to the field. Finally, we highlight some of the questions that remain unanswered.
Effects of <i>Alu</i> insertions on gene function (1998)

Alu elements are a family of short interspersed repetitive elements (SINEs) found exclusively in primates. These elements are around 300 base pairs long, are found in excess of one million copies per diploid genome, and are dispersed throughout the human genome. Alu elements are scattered by a mechanism called "retrotransposition". Three independent steps are involved in retrotransposition: transcription of the Alu repetitive element, reverse transcription of the Alu RNA and integration of the Alu cDNA. The fact that Alu elements retrotranspose so readily suggests that they have a myriad of effects on the genome, mostly by inactivating genes or altering their function. These characteristics of Alu repetitive elements point to these repetitive DNA fragments as a major driving force for evolution. In addition, Alu elements are known to adopt diverse functions depending on the context of the surrounding genetic material into which they insert. In this article, we review some of the evidence that demonstrates the functional significance of Alu repeats.
The scattering of fast electrons by crystals (1979)

Electron diffraction and microscopy are among the most important techniques for studying the structures of solids. This review aims to give a comprehensive introduction to the basic principles of the scattering of fast electrons and to highlight selected applications of importance. It begins by discussing electron scattering by single atoms and describes how single atoms may be imaged. The geometry of diffraction from perfect single crystals is then considered and a simple kinematical theory which yields approximate values for diffracted intensities is given. It is shown how simple principles have been used to image monatomic steps on the surface of crystals. More accurate methods of calculating diffracted intensities are given and particular attention is paid to describing concepts often found to be difficult, for example the dispersion surface. Principles of various recent electron scattering techniques are outlined including high-voltage electron microscopy, scanning electron microscopy, convergent-beam electron diffraction and the critical voltage effect. Applications described range from measuring bonding electron charge densities to the imaging of dislocations. Finally some recent theoretical developments on the problem of imaging imperfect crystals at atomic resolution are discussed.
Arthur Jensen and His Critics: The Great IQ Controversy (1973)

(1973). Arthur Jensen and His Critics: The Great IQ Controversy. Change: The Magazine of Higher Learning: Vol. 5, No. 4, pp. 33-37.
Bucket rotor wind-driven generator (1973)

As compared with the ordinary propeller type rotor, the bucket rotor is limited in rotational speed since the tip rotor speed can never exceed the wind speed. However, it does not present the blade fatigue problem that the ordinary rotor has, and it perhaps causes less sight pollution. The deflector vanes also provide a venturi passage to capture greater wind flow. The bucket rotors can be strung together end-to-end up to thousands of feet long to produce large amounts of power.
On starch (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn starchRobert S. Shane Cite this: J. Chem. Educ. 1937, 14, 10, 460Publication Date (Print):October 1, 1937Publication History Received3 August 2009Published online1 October 1937Published inissue 1 October 1937https://doi.org/10.1021/ed014p460RIGHTS & PERMISSIONSArticle Views156Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
Restrictive Import Regulations on Pornography: Public Morality of Protectionism? (1992)

Great Britain has long been committed to tight customs control of obscene materials and, anticipating the fall of trade barriers by 1993, is considering legislative initiatives to further curtail the importation of pornography. 1 Although British officials claim that nothing in European Community ("EC") treaties or legislation prevents such actions, Article 30 of the Treaty establishing the European Economic Community ("EEC Treaty" or "Treaty") forbids any import prohibition effecting a quantitative restriction on other Member States. 2 Because British law employs separate standards for domestic and imported pornography, Great Britain's selective regulation arguably violates the EEC Treaty's antidiscrimination provisions.This Comment explores such selective and restrictive regulations on the movement of pornographic materials in the EC.Part I examines the rationales behind U.S and British laws restricting the sale and export of pornography.Part II contends that the proposed British restrictions violate Article 30 of the EEC Treaty, as Great Britain allows the domestic production and marketing of certain pornography, while restricting the importation of similar material.Part III analyzes several provisions of the EEC Treaty that may provide exceptions to Article 30 for Britain's antipornography regulations: the public morality clause of Article 36; Article 234, which permits trade restrictiv'e agreements concluded prior to Member State accession to the EC; and Article 115, which allows temporary t B.A. 1990, Smith College; J.D. Candidate 1993, Unihersity of Chicago.British efforts to bolster antipornography legislation are due, in part, to the controversy surrounding "After Twelve," a new all-night satellite television channel that plans to
A testing machine for dental air-turbine handpiece characteristics: free-running speed, stall torque, bearing resistance. (2005)

The measurement of performance characteristics of dental air turbine handpieces is of interest with respect to product comparisons, standards specifications and monitoring of bearing longevity in clinical service. Previously, however, bulky and expensive laboratory equipment was required. A portable test machine is described for determining three key characteristics of dental air-turbine handpieces: free-running speed, stall torque and bearing resistance. It relies on a special circuit design for performing a hardware integration of a force signal with respect to rotational position, independent of the rate at which the turbine is allowed to turn during both stall torque and bearing resistance measurements. Free-running speed without the introduction of any imbalance can be readily monitored. From the essential linear relationship between torque and speed, dynamic torque and, hence, power, can then be calculated. In order for these measurements to be performed routinely with the necessary precision of location on the test stage, a detailed procedure for ensuring proper gripping of the handpiece is described. The machine may be used to verify performance claims, standard compliance checks should this be established as appropriate, monitor deterioration with time and usage in the clinical environment and for laboratory investigation of design development.
From Gene Targeting to Genome Editing: Transgenic animals applications and beyond (2015)

Genome modification technologies are powerful tools for molecular biology and related areas. Advances in animal transgenesis and genome editing technologies during the past three decades allowed systematic interrogation of gene function that can help model how the genome influences cellular physiology. Genetic engineering via homologous recombination (HR) has been the standard method to modify genomic sequences. Nevertheless, nuclease-guided genome editing methods that were developed recently, such as ZFN, TALEN and CRISPR/Cas, opened new perspectives for biomedical research. Here, we present a brief historical perspective of genome modification methods, focusing on transgenic mice models. Moreover, we describe how new techniques were discovered and improved, present the paradigm shifts and discuss their limitations and applications for biomedical research as well as possible future directions.
A dual-mode microstrip ring resonator filter with active devices for loss compensation (2002)

A novel bandpass filter design is presented which uses a dual-mode microstrip ring resonator with a pair of FETs which provide negative resistance to compensate for the losses in the ring. The measured results show excellent performance, with a 32-MHz, 3-dB bandwidth centered at 1.48 GHz. The technique used is particularly attractive because of its ability to implement two transmission poles and two transmission zeros with only one ring if a suitable mode-coupling structure is designed. The advantage of the combined passive resonator and active device technique is that the poles and zeros of the filter are accurately defined by the ring dimensions, and the FETs only provide negative resistance to compensate for the ring losses. Hence, the filter is less sensitive to environmental changes than a filter based on entirely active techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dynamics of pothole growth as defined by field data and geometrical description (2005)

This paper examines cylindrical pothole growth on streambeds using empirical analyses of field data and geometric constraints. Pothole depths ( d ) and average radii ( ) at three localities have the relationship = kd , where k and ɛ are regression coefficients ( R 2 ≥ 0.72). Observed ɛ (0.57, 0.67, 0.85) translate to d increasing faster than r at all localities. The strong correlations and absence of potholes with very low or high ratios of depth/diameter suggest that small concavities act as pothole seeds and enlargement is quasi‐systematic. Exploiting the power relationship, growing potholes can be represented as deepening and radially expanding cylinders. Absolute and relative distributions of erosion can be calculated for floors and walls using this geometrical approach. Volumetrically, more substrate is eroded from pothole walls than floors during growth for ɛ > 0.5. Among sample populations, as much as 70% more material is eroded from walls than floors (ɛ = 0.85). Wall and floor surface areas differ by 1 or more orders of magnitude for observed ɛ, and as a result, erosion rates are fastest atop floors. Differences in erosion rates may reflect the efficacy of erosion phenomena. Low‐angle impacts of tools on walls presumably have low erosion efficiencies. Efficacies are presumably influenced by substrate properties, and floor and wall erosion rates are most comparable in the weakest observed strata, although substantially more material is removed from walls at this locality (ɛ = 0.85). Additional data is needed, but quantifiable relationships may exist between geometries, substrates, and erosion phenomena.
Bone marrow purging and processing--a review of ancillary effects. (1990)

This paper differs markedly from the others that are being presented at this symposium, in that it does not describe a particular technique, or have a single unifying theme. Its aim is to draw to the attention of the purging community a list of variables that we all have tended to regard as only secondarily important to our primary goal of target cell depletion, or collection. It is often difficult to remember that ex vivo purging treatments are composed of multiple steps, and that, in turn, purging is a single component of a complex treatment protocol. In order to cope with this diversity, the natural tendency has been to focus on manageable segments. While this can speed development, we need to constantly be aware that there are multiple factors, both within and outside of our own particular segment, that can impact on the final result. Variables that we often regard as unimportant, or techniques that are thought of as routine, may ultimately be influencing clinical outcome. It would be naive to suggest that we can ever have control over all of the variables in any procedure that is part of a clinical treatment. One purpose of this paper is simply to draw the existence of these factors to the attention of investigators, and suggest that their potential impact may not always be fully appreciated. Secondly, the selective separation of cells from bone marrow is sufficiently well established that it should now be possible to evaluate the technology, reagents and variables in a systematic and collaborative fashion. While we may not emerge from such an exercise with unity of option, we may at least lay the foundations for the further development of this type of therapy, and provide the framework for addressing future questions.
Value-Added (1985)

This article presents a systematic approach to accountability and academic support on the part of institutional student affairs areas. The paper contends that the major mission of colleges and universities should be academic and intellectual achievement, and that the true effectiveness of student affairs programs should be judged in this light. The Value-Added concept is discussed as an alternative to student development as a unifying theme in student affairs. Specific Value-Added tasks with student affairs are cited as examples.
The use of immunotherapy in the treatment of melanoma (2017)

Patients with advanced melanoma have a compromised anti-tumor immune response leading to tumor immune tolerance and a tumor microenvironment conducive to disease progression. Immunotherapy that successfully overcomes this tumor-mediated immune suppression has made the greatest impact in the management of this disease over the past few years. This progress through immunotherapy builds upon earlier successes that interferon-α had in the treatment of melanoma in the adjuvant setting, as well as that of high-dose interleukin-2 in advanced melanoma. The development of immune checkpoint inhibitors has led to dramatic clinical activity in advanced melanoma. In particular, anti-CTLA4 and anti-PD1 monoclonal antibodies have taken us forward into the realm of longer survival and durable responses with the possibility of cure in a continuously increasing proportion of patients. Combination immunotherapeutic strategies and novel immunotherapeutic agents are being tested at an accelerated pace where the outlook for long-term survival benefits for the majority of patients appears brighter than ever.
Improving the accuracy and the efficiency of geo-processing through a combinative geo-computation approach (2016)

Geographical Information Systems (GIS) have become widely used for applications ranging from web mapping services to environmental modelling, as they provide a rich set of functions to solve different types of spatial problems. In the meantime, implementing GIS functions in an accurate and efficient manner has received attention, throughout the development of GIS technologies. This thesis describes the development and implementation of a novel geo-processing approach, namely Combinative Geoprocessing (CG), which is used to address data processing problems in GIS. The main purpose of the CG approach is to improve the data quality and efficiency of processing complex geo-processing models. Inspired by the concept of Map Calculus (Haklay, 2004), in the CG approach GIS layers are stored as functions and new layers are created through a combination of existing functions. The functional programming environment (Scheme programming language) is used in this research to implement the function-based layers in the CG approach. Furthermore, a set of computation rules is introduced in the new approach to enhance the performance of the function-based layers, such as the CG computation priority, which provides a way to improve the overall computation time of geo-processing. Three case studies, which involve different sizes of spatial data and different types of functions are investigated in this research in order to develop and implement the CG approach. The first case study compares Map Algebra and our approach for manipulating two different raster layers. The second case study focuses on the investigation of a combinative function through the implementation of the IDW and Slope functions. The final case is a study of computational efficiency using a complex chain processing model. Through designing the conceptual model of the CG approach and implementing the CG approach in the number of case studies, it was shown that the new approach provides many advantages for improving the data quality of geo-processing. Furthermore, the overall computation time of geo-processing could be reduced by using the CG approach as it provides a way to use computer resources efficiently and avoid redundant computations. Last but not least, this thesis identifies a new research direction for GIS computations and GIS software development, such as how a robust geo-processing tool with higher performance (i.e. data quality and efficiency) could be created using the CG approach.
A perspective on 'Perspectives': a response to the Spring 1987 issue of Consensus (1988)

In our Spring 1987 issue of Consensus we invited readers to respond to the "Perspectives on Evangelicalism/Fundamentalism/Neo-Conservatism" that were put forward by the various LTS professors.There were many affirmative verbal responses, but to date we have received only one written response.It comes from Wayne Turner.Mr. Turner, who brings a strong background in philosophy to his M.T.S. studies at our Seminary in Saskatoon, finds some logical fallacies in the argu- mentation; he argues that the incorporation of these fallacies confuses the issue and keeps the authors from being able "to assess the relative merits of each position."We hope this con- tribution will help to clarify the debate and keep the discussion alive.
Current, April 17, 1969 (1969)

https://irl.umsl.edu/current1960s/1064/thumbnail.jpg
Recovery of Chlamydia trachomatis from the Endometrium of Women at Risk for Chlamydial Infection (1987)

JONES, ROBERT B.; MAMMEL, JAMES B.; SHEPARD, MARGUERITE K.; FISHER, ROBERTA R. Author Information
The Solomonic Paradox Revisited: Should Custody Proceedings Determine a Child's Religion? (1993)

With the eyes of a child You must come out and see That your world's spinning roundAnd through life you will be A small part of a hope of a love that existsIn the eyes of a child you will see ...
Educational/Institutional Features of the Optical Videodisc System (1977)

A reflective optical videodisc system with laser readout is described in terms of its consumer and educational/institutional applications. The system will find practical realizations in a home information/entertainment center and in more elaborate machines with peripherals for the larger applications. A major feature is the complete interchangeability of all programmed discs so that any disc can he played on any model of the machine. The educational/institutional model can, at the user's discretion, be interfaced with a microprocessor, a keyboard, and/or a variety of other peripherals. The first few thousand tracks on the disc can store branching instruction sequences to control the display of frames on the rest of the disc. Paragraph, chapter, and frame-by-frame selection of mixed still and motion sequences is possible with identification codes. One side of the disc provides up to 30 min of continuous play in color or monochrome with two discrete audio channels. The NTSC color system is used so as to ensure that neither the disc nor the videodisc system is a limiting factor in performance.
Automated deployment of IoT services based on semantic description (2015)

The Internet of Things (IoT) is making it possible for a large number of heterogeneous physical objects (or referred as “Things”) to be connected to the Internet. However, as more and more things are getting connected, interoperability issues have been raised as one of major challenges in achieving the vision of IoT. To cope with this issue, many researches and industry communities have begun to adopt Web technologies such as HTTP, JSON, and REST. With the current trend of the Web of Things (WoT), we encounter various IoT platforms (or middlewares) which are able to collect, manage and mashup a huge mass of things and their data. Considering the large number of heterogeneous things deployed across different platforms, the interoperability problem between things and platforms has now come to the fore. In this paper, we present a semantic approach to generating a service description and deploying a set of heterogeneous things to different platforms automatically.