gebhart/patrepeval huggingface dataset:
A ciliary neurotrophic factor-sensitive human myeloma cell line. (1996)

We obtained a human myeloma cell line (XG4-CNTF) whose growth was completely dependent on addition of ciliary neurotrophic factor (CNTF). Half-maximal proliferation was induced by adding 20 pg/mL CNTF. Response to CNTF correlated with expression of membrane CNTF receptor alpha-chain (CNTFR alpha), as shown by PCR analysis and immunostaining with anti-CNTFR alpha antibodies. CNTF-induced proliferation was completely inhibited by antibodies to gp130 interleukin-6 (IL-6) transducer, unlike antibodies to IL-6 or IL-6 receptor (IL-6R). Growth of XG4-CNTF cells using the gp130 IL-6 transducer was also supported by other cytokines: IL-6, leukemia inhibitory factor (LIF), and oncostatin M (OM). This cell line should be very useful for studying the interactions of IL-6-related cytokines with their receptors.
Free Fatty Acid Composition of the Adipose Tissue of Intact and Castrated Lambs Slaughtered at 12 and 30 Weeks of Age (1996)

Free fatty acids from adipose tissue of rams and wethers slaughtered at 12 and 30 weeks of age were isolated by a modified Bligh and Dyer method and analyzed by gas chromatography−mass spectrometry. A total of 15 free fatty acids were positively identified. At 12 weeks of age, rams had nonsignificantly higher levels of the flavor-significant compounds, 4-methyloctanoic and 4-methylnonanoic acids, than wethers. At 30 weeks of age, differences in the levels of these acids in rams and wethers became significant and 4-methyloctanoic and 4-methylnonanoic acids increased by 13- and 4-fold, respectively, in the noncastrated animals. Log odor unit values indicated that 4-methyloctanoic acid was present at or above its odor threshold value in rams and wethers of both slaughter ages, but that the value was much higher for 30-week-old rams. 4-Methylnonanoic acid was present below its odor threshold value in all samples. Keywords: Branched-chain fatty acids; fatty acids; adipose tissue; lamb; sheepmeat
Tribologische Sub-Mikrometer Schichten für Mikrosysteme (2002)

S.87-91
The priming stimulus dictates senescence of memory T cells (46.15) (2011)

Abstract Immunization drives the proliferation and differentiation of effector CD8 T cells followed by a contraction phase after the peak of the T cell response. The survivors of this contraction phase differentiate into long-lived memory cells, which can provide life-long protection. Generating long lived T cell memory through vaccination holds great promise to provide protection in situations where antibody-inducing vaccines fail. Prime-boost strategies have been used to repeatedly stimulate T cells with the aim of increasing memory T cell frequency. However, repeated stimulation of the memory T cell pool leads to T cell senescence and loss of responsiveness. We sought to determine whether a prime-boost vaccination strategy can be developed that does not suffer from this drawback. We report that the extent of senescence at the memory stage is determined during the primary response. We developed a system that allows priming of CD8 T cells without acquisition of maximal effector function and show that the ensuing memory population is fully functional upon rechallenge. Importantly, these memory cells derived from minimal effector T cells have full access to non-lymphoid tissue and are less senescent upon rechallenge than memory cells that did acquire maximal effector markers and function during priming. Understanding how the nature of the priming stimulus shapes memory T cell differentiation allows situation dependent tailoring of vaccines to achieve maximal protection efficacy.
<title>Automatic leather inspection of defective patterns</title> (1996)

Constant and consistent quality levels in the manufacturing industry increasingly require automatic inspection. This paper describes a vision system for leather inspection based upon visual textural properties of the material surface. As visual appearances of both leather and defects exhibit a wide range of variations due to original skin characteristics, curing processes and defect causes, location and classification of defective areas become hard tasks. This paper describes a method for separating the oriented structures of defects from normal leather, a background not homogeneous in color, thickness, brightness and finally in wrinkledness. The first step requires the evaluation of the orientation field from the image of the leather. Such a field associates to each point of the image a 2D vector having as direction the dominant local orientation of gradient vectors and the length proportional to their coherence evaluated in a neighborhood of fixed size. The second step analyzes such a vector flow field by projecting it on a set of basis vectors (elementary texture vectors) spanning the vector space where the vector fields associated to the defects can be defined. The coefficients of these projections are the parameters by means of which both detection and classification can be performed. Since the set of basis vectors is neither orthogonal nor complete, the projection requires the definition of a global optimization criteria that has been chosen to be the minimum difference between the original flow field and the vector field obtained as a linear combination of the basis vectors using the estimated coefficients. This optimization step is performed through a neural network initialized to recognize a limited number of patterns (corresponding to the basis vectors). This second step estimates the parameter vector in each point of the original image. Both leather without defects and defects can be characterized in terms of coefficient vectors making it possible to devise a filter process that detects any abnormal part of leather. The resulting system does not depend on kind, dimension and color of defects and uses only local information (it can therefore be implemented in a parallel way for dealing with large pieces of leather). Finally it works also on different materials: it has been used successfully on wood and ferromagnetic materials.
Non-Linear Prediction of Inverse Covariance Matrix for Stap (2007)

For bistatic ground moving target indication radar, the clutter Doppler frequency depends on range for all array geometries. This range dependency leads to problems in clutter suppression through STAP techniques. In this paper, we propose a new approach of applying non-linear prediction theory to address the range dependency problem in bistatic airborne radar systems. This technique uses a non-linear function to obtain an estimate of the range-dependent inverse covariance matrix. Simulation results suggest a non-linear fit for the model (nonlinear relationship between the inverse covariance matrices) and show an improvement in processor performance as compared to conventional STAP methods.
Categorical Color Mapping for Gamut Mapping (1997)

New color mapping method that is useful for gamut mapping is introduced in this paper. This mapping method is named “Categorical Color Mapping” by authors, because it utilizes the categorical color naming to design color segmentation process. This paper shows concept and algorithm of the categorical color mapping and results of simulation regarding gamut mapping.
Biomechanical analysis of buttock soft tissue using computer-aided seating system (2002)

Using a Computer-Aided Seating System (CASS) equipped with ultrasonic transducers, we have performed a preliminary biomechanical analysis of buttock soft tissue. Tissue layer thickness and deformation, and interface pressure response were investigated in vitro using porcine tissue and in vivo with a human subject. The results show that muscle deforms more than skin and fat in response to external loading. The time-phase relationship of peak interface pressure and peak tissue deformation may indicate more information about the viscoelastic properties of soft tissue.
Experimental plant for investigation of the possibility of linac-based production of medicine-intended isotopes (2012)

We describe a technique of obtaining radioactive 99mTc isotope by irradiation of molybdenum with high-intensity beam of bremsstrahlung photons from the electron beam of the linear electron accelerator (LUE50) of the Alikhanyan National Science Laboratory (ANSL, former Yerevan Physics Institute). We have elaborated and created an experimental plant for development of 99mTc production technology. Upgrading of linac has been performed aimed at raising the beam intensity and density. A system of automated control of the parameters of the plant and accelerator was built up. We carried out preliminary studies of 99mTc obtaining technique and give quantitative and qualitative results.
Studies on the Heterogeneity of Mouse‐Globin Messenger RNA (1972)

Mouse reticulocyte messenger (9‐S) RNA has been prepared by treatment of polysomes with sodium dodecylsulphate. On 6% polyacrylamide gels, two sharp and one more diffuse component can be resolved in the 9‐S region. Messenger RNA prepared from 14‐S mRNA · protein from EDTA‐treated polysomes contains only the diffuse component. This component has priming activity for both α‐ and β‐globin chains, and evidence is presented that it can be partially resolved into separate messengers for each chain. The two sharp components, which migrate more slowly than the globin mRNA, are associated with the 30‐S ribosomal subunit after EDTA treatment, have no translational activity in a duck reticulocyte cell‐free protein‐synthesis system, and (unlike the diffuse component) are not destroyed by gentle sonication of polysomes to monosomes. The non‐coding components comprise approximately one‐third of the RNA in the 9‐S region of most RNA preparations from mouse reticulocytes. The diffuse (coding) 9‐S component from 14‐S mRNA · protein runs as a sharp symmetrical peak in formamide‐acrylamide gel electrophoresis, suggesting that there may be variation in secondary structure in aqueous solution rather than in molecular weight.
Multilayer Walk-off Corrected Nonlinear Optical Devices – Engineering of Quasi-Noncritical Phase-Matching to All Wavelengths (2009)

Multilayer walk-off corrected nonlinear crystal composites not only can correct the spatial walk-off, but also can compensate the phase-mismatching caused by incident angle deviation. The noncritical phase-matching-like properties can be engineered to all wavelengths.
Ontogenic Changes in Serum Immunoglobulins and C3 in Vitamin-D Deficient and Malnourished Rats (1987)

In both protein energy malnutrition and vitamin D deficiency, defects in some immunological functions have been noted, but the effects on complement and immunoglobulin concentrations have not been evaluated. We assessed the effects of malnutrition and vitamin D deficiency on immunoglobulins and C3 in rats in early postnatal life during weaning and early adulthood using the rocket immunoelectrophoresis technique. In well-nourished rats, the serum levels of IgG increased from 88.5 +/- 10.2 mg/dl in the newborn period to 883.4 +/- 104.8 mg/dl at weaning (day 19). The adult levels, 1,325.9 +/- 60.8 mg/dl, were attained by 35 days of age. Serum IgA was not detectable by our method until 20 days of age (1.1 +/- 0.2 mg/dl) and reached adult levels (13.4 +/- 3.2 mg/dl) by day 35. IgM was detectable in the serum of pups at 5 days of age (0.4 +/- 0.07 mg/dl), increased to 27.5 +/- 6.9 mg/dl at weaning and approached adult levels (93.7 +/- 9.9 mg/dl) at day 35. C3 levels at birth were only 36% of adult levels and did not change during the suckling period. They then increased to levels comparable to those of adults at the age of 35 days. Serum immunoglobulins and C3 in malnourished rats were not significantly different from age-matched control pups. In pups born to dams fed a vitamin-D-deficient diet from 3 weeks of age, only the serum IgG and C3 levels were significantly lower than those of normal pups at day 1 (IgG level: 65.2 +/- 6.1 vs. 88.5 +/- 10.2 mg/dl; C3 level: 20.3 +/- 6.9 vs. 36.2 +/- 3.1% of an adult level; p less than 0.005). Thus the increased susceptibility of malnourished young animals to infection does not appear to be related to a lowering of serum immunoglobulin and complement concentrations.
β‐Amyloid 1‐42 induces physiological transcriptional regulation of BACE1 (2012)

The pathogenesis of Alzheimer's disease (AD) is only partially understood. β-amyloid (Aβ) is physiologically generated by sequential cleavage of its precursor protein by the β- and the γ-secretase and it is normally disposed of. In Alzheimer's disease, Aβ is excessively produced or less dismissed, but the hypothesis on its physiological and pathological role are heterogeneous and often discordant. It has been described a positive feedback loop from the γ- to the β-secretase cleavages of Aβ precursor protein, which is activated by mutations of Presenilin 1 (PS1), the catalytic core of the γ-secretase. These findings show that Aβ precursor protein as well the activity of the γ-secretase are required to obtain the up-regulation of β-secretase which is induced by Presenilin 1 mutations. Then, Aβ 1-42 is the Aβ precursor protein derivative that up-regulates the expression of β-secretase, and c-jun N-terminal kinase (JNK)/c-Jun and ERK1/2 are involved. Here, we describe the activation of β-secretase and c-jun N-terminal kinase related proteins by monomeric Aβ 1-42, defining the conditions that most efficiently strike the described signaling without producing toxicity. Taken together these data imply that monomeric Aβ 1-42, at non-toxic concentrations and time frames, are able to induce a signaling pathway that leads to transcriptional activation of β-secretase.
Grain decoupling at low magnetic fields in ceramic YBa2Cu3O/sub 7-delta/ (1987)

We observe evidence for grain decoupling at low magnetic fields in ceramic YBa2Cu3O/sub 7-delta/. We find the bulk critical current density of ceramic 123 compound to be unambiguously due to Josephson coupling between grains, based on a theoretical fit to the measured field dependence of J/sub c/. At very low fields the junctions can no longer maintain screening currents and the grains' magnetic response is decoupled. This decoupling is seen in the magnetization versus increasing field. At very low fields the diamagnetic screening appears to be perfect, but drops considerably upon decoupling. The Meissner effect always reflects decoupled grains and the uniaxial anisotropy of the superconductivity. We know that the zero-field critical current density interior to the grains is actually quite high (>10W A/cmS at 5 K) from an analysis of the observed remanent magnetization in terms of decoupled grains. Finally, we note that the bulk J/sub c/ provides a sensitive measure of H/sub cl/.
A Matlab toolbox for robust control synthesis by symbolic computation (2004)

We have presented a new Matlab toolbox for robust control synthesis by symbolic computation. It is based on a parameter space approach accomplished by quantifier elimination and also equipped with a machinery for numerical simulation of the properties in a frequency domain. The toolbox is explained with several examples.
Red, Scaly Babies: Neonatal Erythroderma (2011)

Erythroderma is defined as generalized skin erythema affecting at least 90% of the body. This skin reaction is not specific for one diagnosis. Neonatal erythroderma is potentially life-threatening and presents unique therapeutic and diagnostic challenges. The differential diagnosis is broad, and many of the potential diagnoses are exceedingly rare. Additional clinical or laboratory findings may point to the underlying primary disease, and understanding these clues can expedite establishing the diagnosis. Irrespective of the underlying cause, neonates who have erythroderma have a compromised skin barrier, which can lead to dehydration, electrolyte imbalances, temperature instability, protein losses, and increased risk for infection. This review focuses on an approach to managing erythroderma and reviews the features of several causes of erythroderma.
Reinterpreting quorum sensing as positional sensing in bacterial communication (2006)

Background and Aims\nThe phenomenon of bacterial cell-to-cell communication via n-acyl homoserine lactone molecules was examined in a simple series of direct microscopy tests aimed at verifying the postulates of the current quorum sensing working model. \n\nMethods\nUsing a wild type strain of Rhizobium leguminosarum, we first devised a signal production system in which cell number, cell density and cell distance could be varied at leisure while maintaining the physiological status and preventing further cell divisions. The model was subsequently verified by epifluorescent microscopy in a tri-dimensional set up in LB agar, using an rfp-tagged AHL producing strain of Pseudomonas aeruginosa and a sensor Escherichia coli bearing a gfp-fused AHL reporter gene. \n\nResults \nData obtained by measuring 697 individual cell-to-cell communication distances using the CMEIAS image analysis software showed that indeed quorum sensing can be reduced to an interaction involving as few as two individual cells, with a mean calling distance of 37.4 um and a maximum calling distance extended as far as 123.6 um. Direct microscopy showed that a single bacterium can produce sufficient signal in situ to activate a population of 180 bacterial cells. \n\nConclusions\nThe results indicate that quorum sensing does not comply with the paradigm of a mechanism simply depending on cell density. A novel concept of positionally-releated sensing, via mixing concentration gradients, is presented.
Evaluation of Space-Time Diversity Techniques in Car-to-Car Communications (2015)

Car-to-car (C2C) communications requires reliable connectivity at moderate data rates. This is essential for safety-related applications. The development of such communications systems needs to cope with time-variant propagation channels including shadowing by other vehicles, high Doppler shifts and rich multipath environments. Moreover, the choice of the antennas and their position in/on the car highly influences the overall propagation channel. This paper elaborates on different antenna configurations and diversity techniques to overcome these issues. Especially, Alamouti space-time coding is applied to the 802.11p standard in order to exploit diversity by using two transmit antennas on a car. This configuration as well as maximum ratio and selection combining are then evaluated in terms of frame error rate in an urban car-to-car scenario. With these parameters, the reliable communication range between two cars is derived.
ESTUDIO DE LA CONFIGURACIÓN ELECTRÓDICA DE LA DESCARGA LUMINISCENTE ANORMAL DURANTE EL PROCESO DE ABSORCIÓN DE NITRÓGENO EN ALEACIONES DE Fe-Cr (2007)

"Aleaciones de Fe-Cr son preparadas y sometidas al proceso de absorción de nitrógeno en las configuraciones catódica y anódica de la descarga luminiscente anormal de N2+H2. Utilizando estas dos configuraciones se midió la variación de masa de las muestras de Fe-Cr en función de su contenido de cromo a temperatura de 950ºC y presión total de 10 Torr de la mezcla gaseosa. La estructura de las muestras, después del proceso de absorción de nitrógeno, fue analizada por Difracción de Rayos X. Basados en la información extraída de las muestras se presenta una discusión del comportamiento de las dos configuraciones."
The Effect of Pharmacist-Led Intervention on Surgical Antibacterial Prophylaxis (SAP) at an Orthopedic Unit (2021)

Perioperative antibiotic use is a common reason for antibiotic misuse. Evidence suggests that adherence to SAP guidelines may improve outcomes. The purpose of this study was to analyze the impact of pharmacist-led antibiotic stewardship interventions on SAP guideline compliance. The study was conducted at an Orthopedic Department of a tertiary care medical center. SAP compliance and antibiotic exposure in the pre-intervention and intervention period was compared using chi-square, Fisher exact, and Mann-Whitney tests, as appropriate. Prophylactic antibiotic use in orthopedic joint arthroplasties (overall guideline adherence: agent, dose, frequency, duration), clinical outcomes (length of stay-LOS, number of surgical site infections-SSIs), antibiotic exposure and direct antibiotic costs were compared between pre-intervention and intervention periods. Significant improvement in mean SAP duration (by 42.9%, 4.08 ± 2.08 vs. 2.08 ± 1.90 days, <i>p</i> ˂ 0.001), and overall guideline adherence regarding antibiotic use (by 56.2%, from 2% to 58.2%, <i>p</i> ˂ 0.001) were observed. A significant decrease was observed in antibiotic exposure in SAP (by 41%, from 6.07 ± 0.05 to 3.58 ± 4.33 DDD/patient, <i>p</i> ˂ 0.001), average prophylactic antibiotic cost (by 54.8%, 9278.79 ± 6094.29 vs. 3598.16 ± 3354.55 HUF/patient), and mean LOS (by 37.2%, from 11.22 ± 6.96 to 7.62 ± 3.02 days, <i>p</i> < 0.001); and a slight decrease in the number of confirmed SSIs was found between the two periods (by 1.8%, from 3% to 1.2%, <i>p</i> = 0.21). Continuous presence of the clinical pharmacist led to significant improvement in SAP guideline adherence, which was accompanied by decreased antibiotic exposure and cost.
Development of strip temperature control system for a continuous annealing line (2002)

A sophisticated steel strip temperature control system for the KM-CAL (Kawasaki Multipurpose Continuous Annealing Line) has been newly developed at Mizushima Works of Kawasaki Steel. The control system comprises two subsystems: an expert system for smooth processing of steel strips, and a dynamic setup control system for highly accurate strip temperature control. The expert system examines the operating conditions of the continuous annealing line and makes decisions on how to properly operate the line, while the dynamic setup control system determines the optimum line speed and annealing temperature, using mathematical models based on thermal physics. The control system has been successfully applied to the KM-CAL, securing highly accurate strip temperature control and greatly contributing to the realization of fully automated and efficient operation of the line. As a result, the control has achieved stable product quality at a low production cost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Participation of GABA-ergic structures in producing the effects of haloperidol]. (1980)

A study was made of the effect of haloperidol on convulsions induced in mice by bicuculline and thiosemicarbazide and on the recovery cycles of the primary response in the rat sensorimotor cortex. In doses of 0.3--0.5 mg/kg producing a tranquilizing effect, haloperidol exerts a protective action in convulsions induced by bicuculline blocking of the GABA receptors and enhances the depression of the testing response during recovery cycle of the rat sensorimotor cortex primary response. It means that over this dosage range haloperidol potentiates GABA-induced effects. An increase in the neuroleptic dose up to 1--2 mg/kg entails disappearance of the efficacy shown by both the tests. The authors' own and reported data suggest an important role played by the postsynaptic GABA-positive effect in realization of the tranquilizing action of haloperidol and other neurotropic agents.
DESIGN AND ECONOMIC EVALUATION OF MOBILE BLANKETS FOR FAST REACTORS (1964)

Report evaluating the design characteristics and limitations of mobile blankets for breeder reactors. This also includes economic considerations for each tested blanket. Appendices begin on page 40.
Preoperative Pain Pattern Predicts Surgical Outcome More Than Type of Surgery in Patients With Central Spinal Stenosis Without Concomitant Spondylolisthesis (2013)

4.