gebhart/patrepeval huggingface dataset:
Improving the Antiviral Efficacy and Selectivity of HIV-1 Reverse Transcriptase Inhibitor TSAO-T by the Introduction of Functional Groups at the N-3 Position (2005)

Novel derivatives of the anti-HIV-1 agent, TSAO-T, bearing at the N-3 position a variety of polar, lipophilic, or aromatic groups linked to that position through flexible polymethylene linkers of different length, were prepared and evaluated for their anti-HIV activity. Several compounds (within the series of polar bearing groups) exhibited a 2-6-fold improved antiviral potency with regard to the lead compound, TSAO-T. Moreover, some of the most active N-3 TSAO derivatives retain antiviral activity against the TSAO-T-resistant HIV-1 strain (Glu138 --> Lys). Interestingly, the N-methylcarboxamide derivative 17 was 5- to 6-fold more active (IC50: 0.56 microM) against recombinant HIV-1 reverse transcriptase than the lead compound, thus becoming the most active TSAO derivative synthesized so far. On the other hand, the N-3 methylcarboxamide TSAO derivative 12 turned out to have the highest selectivity index yet reported for this class of compounds (around > or =12 000).
ChemInform Abstract: Transition Metal‐Catalyzed Asymmetric Reactions Using P‐Chirogenic Diaminophosphine Oxides: DIAPHOXs (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multicomponent Multicatalyst Reactions (MC)<sup>2</sup>R: One-Pot Synthesis of 3,4-Dihydroquinolinones (2013)

A Rh/Pd/Cu catalyst system led to an efficient synthesis of dihydroquinolinones in one-pot, two operations. The reaction features the first triple metal-catalyzed transformations in one reaction vessel, without any intermediate workup. The conjugate-addition/amidation/amidation reaction sequence is highly modular, divergent, and practical.
ChemInform Abstract: Conformational Analysis of Antitumor Cyclic Hexapeptides, RA Series. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Uma Ferramenta de Suporte a Recuperação de Informação na Web focada em Vulnerabilidades e Anomalias Internet (2010)

Hoje em dia, administradores de rede e gerentes de TI têm utilizado sítios Web, que contêm informações sobre vulnerabilidades e estatísticas do tráfego Internet, para manterem-se atualizados sobre a atual situação de segurança da Internet e sistemas e, consequentemente, tentarem minimizar o impacto causado por ataques e anomalias. Este trabalho apresenta um sistema de apoio à recuperação de informação na Web (WIRSS) focado em recolher informações sobre segurança disponíveis na Internet, chamado ARAPONGA. Através do uso desta ferramenta é possível concentrar e condensar melhor informações sobre vulnerabilidades e estatísticas do tráfego Internet.
Synthesis, structure and thermal stability of tellurium oxides and oxide sulfate formed from reactions in refluxing sulfuric acid † (2000)

Reactions between Te, TeO2, TeCl4, TeO3 or H6TeO6 and 30–95 wt% H2SO4 were studied at temperatures up to the boiling point of the acid. Depending on the tellurium-containing reactant, H2SO4 concentration and synthesis temperature, Te2O3(SO4), TeO3 or TeO3·xH2O (x = 1.37–1.58) is obtained as the final product (alone or in admixture). The reaction products as well as thermally decomposed and/or crystallized/recrystallized products of these are characterized by powder X-ray diffraction and thermoanalytical techniques. The findings obtained by syntheses with, and thermal decompositions of, H6TeO6 concern three crystalline [TeO3 (I), TeO3 (II) and TeO3 (III) in the present notations] and one amorphous modification of TeO3, an amorphous modification of H2TeO4, one crystalline and one amorphous modification of TeO3·xH2O (x = 1.37–1.58) and two crystalline (one with somewhat more uncertain composition) and one amorphous modification of Te2O5. The crystal structures of TeO3 (I) and Te2O3(SO4) have been redetermined by Rietveld refinements of powder X-ray and neutron diffraction data, respectively.
The Effect of Sulfide Scavengers on Scaling Tendency and Scale Inhibitor Performance (2010)

Abstract Use of continually injected sulfide scavengers has become more widespread in recent years with increased requirement for sulfide scavengers to be injected directly into water producing streams. The chemicals used, especially those based on common triazine chemistries, impact the pH of the produced water, leading to much more severe scaling tendency and impaired scale inhibitor performance. We have found this to be the case with both water-soluble and oil-soluble scavengers, although the effect is less severe with oil-soluble chemicals. The paper describes the results from a range of tests to examine the performance of a number of different scale inhibitor chemical types in the presence of different scavenger chemicals and different brine systems. We also describe the results of scale prediction modelling, as compared to the lab results and show methodologies which improve the reliability of the scale prediction programmes.
Supplementary Table 2 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion (2023)

<p>PDF file, 94K, Multicovariate analysis showing the association between ephrin receptor and ephrin gene expression and overall survival or relapse-free survival in patients resected for a lung adenocarcinoma.</p>
Steroid Induction of Gonadotropin Surges in the Immature Rat. II. Triggering Ability of Progesterone Metabolites,Adrenocortical Hormones, and Adrenocorticotropin* (1978)

Several adrenocortical steroids were tested for their ability to trigger LH release in estrogen-primed sexually immature female rats. Massive LH surges, approaching these known to be triggered by progesterone (P), followed the injection of depot ACTH1-24 and also of the adrenal steroids deoxycorticosterone (DOC) and 4-pregnen-21-ol-3,20-dione 21-acetate, but not of 5 alpha- and 5 beta-pregnan-21-of-3,20-dione, corticosterone, or aldosterone. Estrogen-primed adrenalectomized/ovariectomized rats also responded to DOC, albeit to a lesser extent. The P metabolites 5 alpha-pregnana-3,20-dione, 4-pregnen-20 alpha-ol-3-one, and 3 alpha-hydroxy-5 alpha-pregnan-20-one proved ineffective, although their triggering ability in adults was confirmed. It is concluded that adrenal P and DOC are potent activators of the gonadotropin surge system underlying pubertal ovulation and that P metabolites may acquire biological properties during sexual maturation.
Advances in Analytical Technologies for Correlation of All Hydrocarbon Fluids, Oil Mixtures and Extracts* (2014)

Classical geochemical technology developed decades ago retains value, but in most cases, applications simply retrace previous conclusions and do not open new opportunities. New technologies that deliver the resolving power necessary to distinguish hydrocarbon sources in greater detail and delineate co-sourced petroleum mixtures open new vistas in basin modeling. Here we reveal novel compound specific isotope analysis (CSIA) parameters to accomplish those goals. In order to perform CSIA the targeted compound classes must first be isolated from the petroleum. CSIAs of steranes, hopanes, C12-C40 isoprenoids and C7-C30+ alkanes, terrestrial terpanes (e.g. bicadinane and oleanane), naphthalenes, phenanthrenes and diamondoids are illustrated and examples from worldwide applications to perform source-differentiation are depicted. Laboratory mixtures from different end-member oils from Venezuela, Colombia and the US Gulf of Mexico, respectively, were prepared. Analyses of these mixtures show the power of those new methods for (1) recognition of mixes, (2) determination of all sources, and (3) determination of the relative input from each source. Methods to utilize asphaltenes for biodegraded-oil correlation are also revealed. Asphaltenes preserve original biomarkers and alkanes. Those compounds can be generated by hydrous pyrolysis and used for correlation. While fingerprints of these generated compounds might not match related non-biodegraded oil, the generated biomarkers and alkanes retain isotopic signatures from the kerogen and can be used for correlation by using CSIA methods. Diamondoids are a universal compound class for correlation. With a few exceptions, diamondoids are recalcitrant or inert to alteration by biodegradation and can be used to correlate severely biodegraded oil. They can be sequestered even from severely biodegraded oil or thermally altered condensate and used for correlation with any other petroleum liquids or extracts both by CSIA-D and by fingerprints of large diamondoid molecules (tria-, tetra-, pentamantanes, etc.), termed quantitative extended diamondoid analysis (QEDA).
The Cardiac Output in Rest and Work at Low and High Oxygen Pressures. (1955)

Summary. The cardiac output in rest and work in low oxygen and during work in pure oxygen was determined by means of the dye injection method. In low oxygen (arterial oxygen saturation 65 to 70 per cent) it was found that the cardiac output in rest and work was increased 10 to 20 per cent above the values from control experiments in air. The increase was due to a pulse acceleration as the stroke volume was slightly decreased. In pure oxygen no measurable effects on the cardiac output during work was found. The pulse rate decreased 4 to 8 per cent. The results are discussed with a special view to the possible mechanisms by which the cardiac output is regulated during muscular work.
Cloning of 559 potential exons of genes of human chromosome 21 by exon trapping. (1996)

Chromosome 21 represents approximately 1% of the human genome, and its long arm has been estimated to contain 600-1000 genes. A dense linkage map and almost complete physical maps based on yeast artificial chromosomes (YACs) and cosmids have been developed. We have used exon trapping to identify portions of genes from randomly picked chromosome 21-specific cosmids, to contribute to the creation of the transcription (genic) map of this chromosome and the cloning of its genes. A total of 559 different sequences were identified after elimination of false-positive clones and repetitive elements. Among these, exons for 13 of the 30 known chromosome 21 genes have been "trapped." In addition, a considerable number of trapped sequences showed homologies to genes from other species and to human expressed sequence tags (ESTs). One hundred thirty-three trapped sequences were mapped, and every one mapped back to chromosome 21. We estimate that we have identified portions of up to approximately 40% of all genes on chromosome 21. The genic map of chromosome 21 provides a valuable tool for the elucidation of function of the genes and will enhance our understanding of the pathophysiology of Down syndrome and other disorders of chromosome 21 genes.
Two Different Pigments Capable of Light-induced Absorbance Change at Near Infra-red Region in Chromatophores from <italic>Rhodospirillum rubrum</italic> (1970)

Suspensions of chromatophores from the blue-green mutant (G-9) of Rhodospirillum rubrum were illuminated by 592-nm actinic light, and the consequent steady-state absorbance changes in the near infra-red region were studied: 1) In chromatophores, there are two different types of pigments which undergo light-induced absorbance changes in the spectral region. The two pigments are called Liac-860 and Liac-890 in this paper. 2) Liac-860 is a major pigment responsible for the negative peaks (photo-bleaching) at 860 nm and 810 nm and the positive peak (photo-coloring) at 790 nm in the light-minus-dark difference spectrum, whereas Liac-890 is a pigment responsible for the positive peak at 890 nm in the spectrum. The midpoint oxidation-reduction potentials for these changes of Liac-860 and Liac-890 are +0.45 volt (n=1) and a value more negative than –0.1 volt, respectively. 3) These absorbance changes of Liac-860 and Liac-890 are influenced by the inhibitors of the electron transport system (antimycin A, 2-n-heptyl-4-hydroquinoline-N-oxide and phenylmercuric acetate), by the energy-trapping system (ADP plus P1), and by the uncouplers (2, 4-dinitrophenol, atabrine dihydrochloride, carbonyl cyanide m-chlorophenylhydrazone and ADP plus arsenate), but not by the inhibitor of the energy conservation system (oligomycin). 4) The absorbance changes of Liac-860 and Liac-890 are influenced by proton concentration in the absence of antimycin A, but not in its presence. 5) It is discussed that the light-induced absorbance changes take place on the conversion of Liac-860 to Liac-860+ and of Liac-890 to Liac-890−; Liac-860+ and Liac-890− are the primary electron acceptor and donor, respectively, for the electron transport system which involves a step influenced by proton concentration.
Induced Codeposition of Alloys of W, Mo and Re with the Fe-Group and other Transition Metals (2006)

Abstract not Available.
Chemiluminescent titration of F(g) with Cl2(g) and microwave production of atomic fluorine (1976)

Chemiluminescent titration of atomic fluorine with Cl2 in a low pressure (133 Pa) flow apparatus has been investigated to establish the accuracy of this titration method and the efficiency of F atom production in a microwave discharge. Up to 90 % dissociation of F2(0.5–10 % in Ar) is achieved by a 100 W Evenson-type cavity 2450 MHz discharge when the microwave power exceeds 2500 kJ mol–1 F and discharge residence time exceeds 0.7 ms. Heterogeneous F atom loss on the fluorine-passivated Al2O3 discharge tube walls occurs with a recombination probability, γF≈ 2 × 10–4.Heterogeneous Cl atom recombination does not interfere with the chemiluminescent F/Cl2 titration in glass apparatus since, in the presence of fluorine, γCl(pyrex) < 8 × 10–5. However, homogeneous three-body recombination to form ClF and/or Cl2 produces errors in the titration endpoint which exceed 10 % if the product of F atom partial pressure, total pressure and the mean residence time between titrant addition and chemiluminescent intensity measurement exceeds 160 Pa2 s at 300 K.
Network Topology Design Using Data Envelopment Analysis (2007)

The topology of a network seriously affects its cost, reliability, throughput, and traffic pattern, etc, so we need to simultaneously consider these multiple criteria, which have different units, when evaluating network topologies. However, ordinary methods of network topology design considered only a single criterion. DEA (data envelopment analysis) enables us to simultaneously evaluate multiple criteria, and it has been widely used when evaluating the efficiency of a business or a project. DEA derives the optimality of each candidate by emphasizing strong criteria in its evaluation. In this paper, we apply DEA to network topology design, and we numerically show that it enables us to effectively focus on a small number of desirable topology candidates.
Hyperglycemia Management in Students With Diabetes (2009)

Keywords hyperglycemia, diabetic ketoacidosis (DKA), diabetes management, National Diabetes Education Program (NDEP)
ChemInform Abstract: Concise Synthesis of (4S,5S)‐4,5‐(Isopropylidenedioxy)‐2‐ cyclopentenone (VI) and a Novel C2‐Symmetric Ketone (VII). (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Correlation of gingival biotypes with clinical parameters (2005)

The current progress of the dental treatment in implant and periodontal plastic surgery has led to a further expectation among many patients to the better esthetic results. Predictability of postoperative success is a major consideration in treatment planning both for periodontal treatment and implant treatment. Therefore a careful understanding and analysis of the surrounding tissue is necessary.1) Recently, the dimensions and other characteristics of masticatory gingiva have become the subject of considerable interest in periodontics. For a long time, an “inadequate” zone of keratinized tissue was suggested as a risk factor for the development of gingival recession. That opinion have seriously been questioned by several investigators. Only minimal gingival inflammation has been observed in areas with a very narrow zone of keratinized tissue, and the level of attachment can be maintained even in the absence of attached gingiva provided that the patient maintain proper oral hygiene. Whereas inter-, and intraindividual variation of gingival width has been the subject of numerous investigations, thickness of the gingiva has commanded considerable attention only in recent years. In several other clinical situations, detailed information on the thickness of masticatory mucosa may be highly desirable. For instance, in subjects with thin and vulnerable gingiva, an increased amount of recession is observed following non-surgical periodontal therapy. Moreover, gingival thickness appears to play an important role in wound healing as well as flap management during regenerative and
ChemInform Abstract: X‐Ray Absorption Near‐Edge Structure Evidence for Direct Metal‐Metal Bonding and Electron Transfer in Reduced Rh/TiO2 Catalysts. (1988)

Abstract It is shown that during high temp. reduction (> 623 K) of well‐dispersed Rh/TiO2 catalysts, at least a part of the Rh transforms into species whose X‐ray absorption near‐edge structure (XANES) resembles that of the intermetallic compounds RhTi and Rh 3 Ti.
Perylenediimide-based distributed feedback lasers with holographic relief gratings on dichromated gelatine (2013)

One dimensional second-order distributed feedback (DFB) lasers consisting of polystyrene (PS) films doped with a perylenediimide laser dye, deposited over dichromated gelatine (DCG) photoresist layers with solvent resistant relief gratings recorded by holographic lithography, are reported. The advantage of using the grating on DCG in the final device is that the fabrication process is simplified and the grating pattern better preserved, since no etching methods to transfer the grating to another substrate are needed. A very simple model, proposed to explain the experimental waveguide properties, has allowed identifying the waveguide mode at which DFB emission appears, which was the key to optimize the device performance. In the frame of this model, the thickness of the PS and DCG films could be adjusted in order to minimize the laser threshold and to control its wavelength tuneability. The performance of these lasers is comparable to that of recently reported devices based on the same active material, but deposited over high-quality DFB gratings engraved on SiO2 by nanoimprint lithography.
Chebyshev interpolation for DMT modems (2004)

Sampling clock synchronization in discrete multitone systems, such as digital subscriber line modems can be done with a phase locked loop. This requires expensive analog hardware, such as a voltage controlled oscillator. However, it is possible to use a cheaper free-running oscillator and tackle the problem in the digital domain. Using resampling or interpolation, the timing correction becomes transparent for subsequent equalizers. This article describes a novel resampling technique using Chebyshev polynomials.
Planning the visual measurement of n moving objects by m moving cameras, given their relative trajectories (2011)

This paper presents a planning algorithm suitable whenever n objects must be collectively characterized by m observers and their relative motions are known a priori. This situation arises in Space Situational Awareness (SSA) problems due to the fixed orbits of spacecraft, and also occurs in several other aerospace and manufacturing environments. The new algorithm is a synthesis of two standard methods used to solve combinatorial optimization problems arising from various large-scale constrained active sensor planning applications. The algorithm allows constituent techniques to operate in domains where they perform better. Both constituent methods, Integer Linear Programming (ILP) Relaxation and a Batch-Greedy algorithm, are elaborated in detail. A very powerful feature of the overall approach is that an upper bound on the gap between the found sub-optimal solution and the unknown optimal solution is available. The ILP-relaxation algorithm provides an optimal but physically unrealizable solution, so if realizable performance approaches that of the ILP-relaxation solution, then the sub-optimal solution is very nearly optimal. A visual inspection problem for SSA, which lies in the strongly NP-hard class, is considered and it has been shown that the mixed method yields very nearly optimal solutions in polynomial time. Simulation results confirm the effectiveness of the proposed planning method on different orbits, including Low Earth and geosynchronous orbits.
Clinical evaluation of thioguanosine. (1961)

2-Amino-6-mercapto-9 β -d-ribofuranosylpurine (thioguanosine) has been used orally and intravenously in the treatment of 82 patients with leukemias and disseminated tumors.

The oral dose of thioguanosine required to produce toxic or therapeutic responses was less than half the oral dose of thioguanine necessary to produce comparable results calculated on a molar basis. However, the two compounds were equally active when given by the intravenous route, indicating that the difference in oral dosage of the two compounds was due to a difference in absorption.

Remissions have occurred in diseases which might have been expected to respond to the purine antagonists (acute leukemia in children and adults and chronic granulocytic leukemia) and only in cases which had not already become resistant to 6-mercaptopurine. Thioguanosine therefore appeared to have no qualitative or quantitative advantages over the previously available purine analogs.
Odif For L-Filters (2000)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Manipulation of Ruminal Fermentation IV. Effect of Altering Ruminal pH on Volatile Fatty Acid Production (1972)

The effect of altering ruminal pH on volatile fatty acid production in vitro or volatile acid concentration in viva was investigated. In Experiment 1 three lactating Holstein cows fitted with ruminal cannulae were fed a high-concentrate, restricted roughage ration. Continuous infusion of 9 to 12 moles of sodium bicarbonate into the rumen raised ruminal pH from 5.5 to 6.2 and increased the acetate:propionate ratio from 1.1 to 2.8. A series of in vitro incubations with pH controlled at 5.6, 6.2, or 6.8 showed that volatile acid production was largely unaffected between pH 6.2 and 6.8, but between pH 5.6 and 6.2 acetate production was inhibited, Propionate and butyrate production were increased at pH 5.6.
ChemInform Abstract: Synthesis and Biological Evaluation of Decursin (IIb), Prantschimgin (Ib) and Their Derivatives. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.