gebhart/patrepeval huggingface dataset:
Irreversible enzyme inhibitors. CXIII. Proteolytic enzymes. 3. Active-site-directed irreversible inhibitors of .alpha.-chymotrypsin derived from phenoxyacetamides with an N-fluoro-sulfonylphenyl substituent (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIrreversible enzyme inhibitors. CXIII. Proteolytic enzymes. 3. Active-site-directed irreversible inhibitors of .alpha.-chymotrypsin derived from phenoxyacetamides with an N-fluoro-sulfonylphenyl substituentBernard Randall Baker and Jeffrey A. HurlbutCite this: J. Med. Chem. 1968, 11, 2, 233–241Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://pubs.acs.org/doi/10.1021/jm00308a009https://doi.org/10.1021/jm00308a009research-articleACS PublicationsRequest reuse permissionsArticle Views121Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Crime Victimization in Latin America and Intentions to Migrate to the United States (2010)

Among the challenges faced by Latin America at the onset of the 21st century is the increase in crime and violence that began in the mid-1980s, and which, to one degree or another, has afflicted most countries in the region. In this study we explore the potential implications of the upsurge in crime on migration by testing the hypothesis that crime victimization in Latin America increases the probability that people have given serious thought to the prospect of migrating with their families to the United States. Using Latinobarometro public opinion surveys of approximately 49,000 respondents residing in 17 countries in 2002, 2003, and 2004, the results of a Hierarchical Generalized Linear Model found that, net of individual and country-level control variables, the probability of seriously considering family migration to the United States was around 30 percent higher among respondents who reported that they or a member of their family was a victim of a crime sometime during the year prior to the survey. Evidence that victimization promotes the propensity to emigrate is a finding that contributes to an understanding of the transnational consequences of the increase in crime in Latin America, and adds a new variable to the inventory of factors that encourage people to migrate to the United States.
Correction of systematic errors in quantitative proton density mapping (2011)

Interest in techniques yielding quantitative information about brain tissue proton densities is increasing. In general, all parameters influencing the signal amplitude are mapped in several acquisitions and then eliminated from the image data to obtain pure proton density weighting. Particularly, the measurement of the receiver coil sensitivity profile is problematic. Several methods published so far are based on the reciprocity theorem, assuming that receive and transmit sensitivities are identical. Goals of this study were (1) to determine quantitative proton density maps using an optimized variable flip angle method for T(1) mapping at 3 T, (2) to investigate if systematic errors can arise from insufficient spoiling of transverse magnetization, and (3) to compare two methods for mapping the receiver coil sensitivity, based on either the reciprocity theorem or bias field correction. Results show that insufficient spoiling yields systematic errors in absolute proton density of about 3-4 pu. A correction algorithm is proposed. It is shown that receiver coil sensitivity mapping based on the reciprocity theorem yields erroneous proton density values, whereas reliable data are obtained with bias field correction. Absolute proton density values in different brain areas, evaluated on six healthy subjects, are in excellent agreement with recent literature results.
Kerr, Deborah (Deborah Jane Kerr-Trimmer) (1921–) (2006)

Deborah Kerr was a fine-featured, petite redhead British actress with a distinctive pale complexion. Her performance style was graceful, and marked by an assured physical stature that was ‘ladylike’ yet, at the same time, easily adaptable to playing assertive, distinctive characters. Her compelling
Discourse thanks referees, 2021 (2021)

The Discourse Editorial Team wishes to extend our sincere gratitude to the following academics who have refereed articles which have been published in 2021. All research articles undergo rigorous d...
Review of modeling and control in UAV autonomous maneuvering flight (2018)

The maneuver flight of unmanned aerial vehicles (UAV) is a challenging problem. which has great practical value and academic significance. This paper provides a comprehensive survey of the state-of-the-art of modeling and control of UAV maneuvering flight and exhibits the current status. The topics include maneuver actions definition and classification, modeling and control technology of maneuver UAV. Finally, some new trends for the realization of UAV maneuver flight were summarized.
Effects of nursing intervention in the operating room as recalled on the third postoperative day. (1977)

This study addresses the assumption that coupling between osteoclasts and osteoblasts requires a finely tuned interplay, orchestrated by biochemical messengers, which must follow different scenarios for modeling and remodeling. In particular it is demonstrated that, conceptually, both could be expressions of the same regulatory process, in which osteoclasts function as removers of bone only, and osteoblasts, independently, are recruited by osteocytes to form bone, as mechanical loads dictate. [6 Refs; In English]
Foot and Ankle Characteristics Associated With Impaired Balance and Functional Ability in Older People (2005)

Foot and ankle characteristics, particularly ankle flexibility, plantar tactile sensation, and strength of toe plantarflexor muscles, are significant independent predictors of balance and functional ability in older people. Programs to improve the strength and flexibility of the foot and interventions to augment plantar sensation may be beneficial in improving mobility and reducing the risk of falls.
Improved acoustic modeling with Bayesian learning (1992)

The authors study the use of Bayesian learning for the estimation of the parameters of a multivariate mixture Gaussian density. For speech recognition algorithms based on the continuous density hidden Markov model (CDHMM) framework, Bayesian learning serves as a unified approach for the following four applications: parameter smoothing, speaker adaptation, speaker group modeling, and corrective training. In the approach, the authors use Bayesian learning techniques to incorporate prior knowledge into the CDHMM training process in the form of prior densities of the HMM parameters. The theoretical basis for this procedure is presented. All four applications have been evaluated. Experimental results of the TI connected digit task and the Naval Resource Management task are provided to show the effectiveness of Bayesian adaptation of CDHMM.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Oxide thickness and surface contamination of six endosseous dental implants determined by electron spectroscopy for chemical analysis: a preliminary report. (1990)

Electron spectroscopy and argon ion etching were used to determine the depth and composition of the oxide layers of six competitive dental implant systems. To minimize problems associated with analyzing the active oxide layers, the implants were removed from their original packaging in an oxygen-free environment. The majority of the six implant systems were found to have similar oxide thickness in the range of 20 to 34 A. Some variation was found in the extent of non-oxide surface contamination.
A Study on the Effect of Various Forecast Bias Removal Methods on the Accuracy of Ship's Weather Routeing (2012)

Numerical Weather Prediction products used in ship's weather routeing contain significant forecast errors due to imperfect initial conditions and or imperfect knowledge of the mechanic governing the evolution of the atmosphere, a part of these errors occurs systematically (called bias). The optimal routes computed using such forecasts show a deviation from the actual optimal route. Because these biases are so systematic, statistical methods can be successfully used to correct for them. In this study the temporal and spatial evolution of forecast errors and their systematic biases, for surface wind and ocean wave fields issued by the Japanese Meteorological Agency are studied. The systematic biases are computed for various training period, and the effect of these removal methods on the accuracy of a minimum time route is investigated by carrying out simulations using a container ship sailing over the Northern Pacific Ocean. The different obtained routes are compared to and scored against the most optimal route obtained relying only forecast analysis. Results show that a dynamic running bias method requiring a relatively short period of forecast data archival achieves relatively good results especially during periods of unstable and or bad weather.
Utilisation of Oil Palm Ash in Foamed Concrete (2014)

This study is a part of an on-going research examining the properties of foam concrete when replacing the cement with semi-processed Oil Palm Ash (OPA). Replacements range from 25% to 65% were used for a mix having the mix ratio of (1:2:0.45) and having the target density of 1300kg/m3. All mixes were tested for their strength using the compressive, splitting tensile and flexural strengths up to the age of 28 days. Results show that a 25% replacement level exhibited higher compressive and splitting tensile strength than that of the control mix at the age of 28 days. However, the same replacement level exhibited a close strength to that of the control mix when tested for the flexural strength at the same age.
The Study of Gender in the Employment Relationship: Some Evidence from the Australian Child-care Industry (1998)

A number of explanations have been proposed for the different labour market profiles of males and females. One failing of these explanations is that the academic discourse on gender and paid work overemphasises females and ignores males. This article reviews these explanations and notes that deficiencies can be found with most of the propositions. The least helpful are the analysis that affirm the sex of the worker is the most dominant influence. Supplementing the literature with data from the Australian child-care industry it is suggested that domestic commitments and work centrality are more convincing explanations for the different employment experiences of males and females. It is also suggested that the private domestic domain shapes the status of female dominated occupations. Consequently, research into the paid work experiences of males and females needs to reconcile a range of economic and social factors with gender relations to fully understand both male and female behaviour in the labour market.
Twitter data clustering and visualization (2016)

We present a system for the acquisition, analysis and visualisation of Twitter data. Twitter messages are harvested and stored in a distributed cluster, and the data is processed using algorithms implemented in a MapReduce framework. We present a clustering algorithm capable of identifying the main topics of interest in a tweet data set. Also, we designed a visualization method which allows to follow the intensity of Twitter activity at a given geographical location.
High-Conversion-Ratio Switched-Capacitor Boost DC-AC Inverter Using Sinusoidal PWM Control (2010)

(HCRSC) boost DC-AC inverter is proposed based on sinusoidal-pulse-width-modulation (SPWM) control to achieve step-up DC-AC inversion and regulation. The power stage of the inverter is composed of HCRSC DC-DC booster and H-bridge DC-AC inverter connected in series between source Vs and output Vo. In the HCRSC booster, there are 4 SC capacitor cells with the interleaved and complementary operations in order to provide the 3x3 voltage gain at most. In the H-bridge, there are 4 MOSFETs included for the voltagemode inversion, and by combining SPWM control, it is required that output Vo is following the reference Vref. This compensation is used not only to enhance the regulation to various outputs or source disturbance, but also to make the design of output filter easier for the better total harmonic distortion (THD). Here, the HCRSC boost DC-AC inverter is simulated by OrCAD, and the results are illustrated to show the efficacy of the proposed scheme. Index Terms—high-conversion-ratio; switched-capacitor; boost DC-AC inverter; sinusoidal-pulse-width-modulation.
Preemption Analysis After Geier v. American Honda Motor Co. (2001)

Federal preemption of state claims forms a crucial defense in many product liability cases.Such preemption can foreclose plaintiffs' remedies or greatly reduce the types and amount of damages that plaintiffs can seek.'Preemption can also keep a litigant out of state court.'In addition, conventional wisdom says that federal juries are more frugal with damages and that federal judges are more favorable to defendants. 3 As a result, product manufacturer defendants have an enormous incentive to seek preemption, and plaintiffs have an enormous incentive to keep their claims from being preempted.Traditionally, preemption analysis has been based on the three categories set forth by the Supreme Court in the 1912 case of Savage v. Jones: 4(1) express preemption, where Congress explicitly defines the extent to which its enactments preempt state law; (2) field preemption [also known * J.D. expected
Design of Smart Charger for Series Lithium-Ion Batteries (2006)

This paper presents the development of battery charger for charging series Li-ion batteries. It discusses the basic concepts of Li-ion battery charging such as the method of charging, cell balancing, charging control, monitoring, safety protection as well as the design constraints. The experimental results obtained are also presented
Pressure Ulcers: What Clinicians Need to Know (2010)

Pressure ulcer treatment is one of many aspects of patient care in which nursing care interfaces directly with clinician-provided medical services. Traditionally, the treatment of pressure ulcers has been left to nurses. No less an authority than Florence Nightingale said in 1859, “If he has a bedsore, it's generally not the fault of the disease, but of the nursing.”1 Physicians have tended to be passive participants, routinely cosigning orders written by hospital-based wound-care nurses or home health nurses. Realization of the costs associated with the treatment of pressure ulcers and recent requirements by third-party payers have prompted physicians to become more actively engaged in the prevention, identification, and treatment of pressure ulcers.

Pressure ulcers are localized areas of tissue damage or necrosis that develop because of pressure over a bony prominence. They have previously been called pressure sores, bedsores, and decubitus ulcers, terms that imply that only bed-bound, nonambulatory patients develop pressure ulcers. It is important to recognize that patients who are ambulatory can also develop pressure ulcers, although reduced mobility is still a major risk factor.

The purpose of this article is to familiarize physicians and other clinicians who provide care to hospitalized patients, such as physician assistants, certified nurse midwives, and nurse practitioners, with some of the terminology associated with pressure ulcers, so that they can better assess patients at risk for the development of pressure ulcers and properly identify and describe pressure ulcers.
Towards Autonomous, Adaptive, and Context-Aware Multimodal Interfaces : Theoretical and Practical Issues (2011)

This volume brings together the advanced research results obtained by the European COST Action 2102: “Cross Modal Analysis of Verbal and Nonverbal Communication”. The research published in this book was discussed at the 3rd joint EUCOGII-COST 2102 International Training School entitled “Toward Autonomous, Adaptive, and Context-Aware Multimodal Interfaces: Theoretical and Practical Issues ” and held in Caserta, Italy, on March 15-19, 2010.
Better than expected or as bad as you thought? The neurocognitive development of probabilistic feedback processing (2009)

Learning from feedback lies at the foundation of adaptive behavior. Two prior neuroimaging studies have suggested that there are qualitative differences in how children and adults use feedback by demonstrating that dorsolateral prefrontal cortex (DLPFC) and parietal cortex were more active after negative feedback for adults, but after positive feedback for children. In the current study we used functional magnetic resonance imaging (fMRI) to test whether this difference is related to valence or informative value of the feedback by examining neural responses to negative and positive feedback while applying probabilistic rules. In total, 67 healthy volunteers between ages 8 and 22 participated in the study (8-11 years, n = 18; 13-16 years, n = 27; 18-22 years, n = 22). Behavioral comparisons showed that all participants were able to learn probabilistic rules equally well. DLPFC and dorsal anterior cingulate cortex were more active in younger children following positive feedback and in adults following negative feedback, but only when exploring alternative rules, not when applying the most advantageous rules. These findings suggest that developmental differences in neural responses to feedback are not related to valence per se, but that there is an age-related change in processing learning signals with different informative value.
An in vitro model of ischemia: metabolic and electrical alterations in the hippocampal slice (1984)

The transverse guinea pig hippocampal slice preparation was used to model the metabolic changes which occur in vivo during ischemia and recovery. Perfusing brain slices with medium devoid of glucose and oxygen elicits rapid decreases in phosphocreatine, ATP, intracellular pH, and in the evoked field potential recorded in the dentate gyrus. AMP and creatine rise during this period, while ADP and lactate levels remain unchanged. Cyclic AMP exhibits a transient increase in concentration. With the exception of ADP and lactate, these responses are very similar to those observed during in vivo ischemia. The return of glucose and oxygen to the incubation medium reverses these metabolic and electrophysiological effects and also leads to pronounced elevations in cyclic nucleotide concentrations. Metabolite concentrations approach, but do not reach, in vitro steady state levels during the first 30 min of recovery. Total adenylate and creatine steady state levels are approximately 50% of in vivo concentrations. The results suggest that, although hippocampal slices differ metabolically from in vivo tissue, they exhibit a similar pattern of metabolic responses to ischemic and reflow conditions.
Computer graphics achievement award (2008)

ACM SIGGRAPH recognizes Ken Perlin for his broad contributions and impact across computer graphics, ranging from novel mathematical approaches for modeling to hardware interfaces. His creative research approach has produced many innovations in rendering, modeling, animation and user interfaces, and has inspired several new lines of research.
Sorting of small infectious virus particles by flow virometry reveals distinct infectivity profiles (2015)

The nature and concentration of lipids and proteins at the surface of viruses are essential parameters for determining particle infectiveness. Historically, averaged bulk analysis of viral particles has been the primary method to quantitatively investigate these parameters, though this neglects heterogeneity within populations. Here we analyse the properties of Junin virus particles using a sensitive flow virometry assay and further sort virions while conserving their infectiveness. This method allows us to characterize the relationship between infectivity, virus size and RNA content and to compare particles secreted by Vero cells with those from physiologically relevant human primary macrophages. Our study highlights significant differences in particle infectivity according to its nature, the type of producer cells and the lipid membrane composition at the budding site. Together, our results present the flow virometry assay as a powerful and versatile tool to define virus particle profiles.
Transforming growth factor beta regulates the inhibitory actions of epidermal growth factor during granulosa cell differentiation. (1986)

The effects of transforming growth factor beta (TGF-beta) on epidermal growth factor (EGF) receptor content and EGF action were studied in cultured granulosa cells from immature diethylstilbestrol-implanted rats. During follicle-stimulating hormone (FSH)-induced differentiation in vitro, EGF receptors increased by 20-fold as measured by the binding of 125I-EGF to the intact cells. Addition of TGF-beta during the 48-h culture period amplified the stimulatory effects of FSH on EGF receptors up to 2-fold, with ED50 and maximal concentrations of 2.5 and 8 pM, respectively. Also TGF-beta alone in amounts from 1.6 to 16 pM increased EGF receptor content 4-fold. The stimulatory effects of TGF-beta were due to increased numbers of EGF receptors/cell, since the growth factor had no effect on the Kd (3-5 X 10(-11) M) of the high-affinity EGF binding site. TGF-beta action was observed within 20 h of granulosa cell culture and was maximal by 48 h of a 96-h culture. The stimulatory actions of TGF-beta in gonadotropin-induced cells were exerted through the cAMP effector system of the granulosa cell, since the growth factor also amplified the induction of EGF receptors by cholera toxin, forskolin, and 8-bromo-cAMP. The augmentation of EGF receptors by TGF-beta resulted in a parallel 2-fold increase in the inhibitory effects of EGF on FSH-induced cAMP production and luteinizing hormone receptor expression during granulosa cell development. TGF-beta did not increase granulosa cell numbers during culture although it elevated [3H]thymidine incorporation into DNA by 2-fold over that of FSH-treated cells. These results indicate that TGF-beta regulates the effects of both FSH and EGF during granulosa cell differentiation and provides evidence that ovarian function may be controlled by the combined actions of gonadotropins and multiple growth factors.