gebhart/patrepeval huggingface dataset:
Quantitative proteomics reveals novel therapeutic and diagnostic markers in hypertension (2014)

Hypertension is a prevalent disorder in the world representing one of the major risk factors for heart attack and stroke. These risks are increased in salt sensitive individuals. Hypertension and salt sensitivity are complex phenotypes whose pathophysiology remains poorly understood and, remarkably, salt sensitivity is still laborious to diagnose. Here we present a urinary proteomic study specifically designed to identify urinary proteins relevant for the pathogenesis of hypertension and salt sensitivity. Despite previous studies that underlined the association of UMOD gene variants with hypertension, this work provides novel evidence showing different uromodulin protein level in the urine of hypertensive patients compared to healthy individuals. Notably, we also show that patients with higher level of uromodulin are homozygous for UMOD risk variant and display a decreased level of salt excretion, highlighting the essential role of UMOD in the regulation of salt reabsorption in hypertension. Additionally, we found that urinary nephrin 1, a marker of glomerular slit diaphragm, may predict a salt sensitive phenotype and positively correlate with increased albuminuria associated with this type of hypertension.
Stability of Gabor Frames Under Small Time Hamiltonian Evolutions (2016)

We consider Hamiltonian deformations of Gabor systems, where the window evolves according to the action of a Schrödinger propagator and the phase-space nodes evolve according to the corresponding Hamiltonian flow. We prove the stability of the frame property for small times and Hamiltonians consisting of a quadratic polynomial plus a potential in the Sjöstrand class with bounded second-order derivatives. This answers a question raised in de Gosson (Appl Comput Harmonic Anal 38(2):196–221, 2015)
Modeling of ultrabroadband and single-cycle phenomena in anisotropic quadratic crystals (2011)

We present a comprehensive model to describe the propagation of single-cycle and broadband optical pulses in anisotropic, dispersive, and nonlinear materials. Two nonlinear coupled wave equations describe the dynamics and interactions of optical pulses in uniaxial second-order nonlinear materials. The equations are first order in the propagation coordinate and are valid for arbitrarily wide pulse bandwidth, providing an accurate modeling of the evolution of ultrabroadband pulses also when the separation into different coupled frequency components is not possible or not profitable. We exploit this model to simulate recently observed femtosecond single-cycle multiterahertz transients in gallium selenide and to predict harmonic generation and spectral broadening in the visible and mid-infrared in lithium niobate.
Pump-probe study of plasma generated with linear and circularly polarized filaments in nitrogen (2014)

We study the dynamics of the plasma generated with 800nm filaments of 60fs in a pump-probe system in nitrogen cell. We see the effect of molecular revival and plasma dynamics on beam profile and spectrum.
Development to the blastocyst stage, the oxidative state, and the quality of early developmental stage of porcine embryos cultured in alteration of glucose concentrations in vitro under different oxygen tensions (2006)

These results show that a decrease in developmental ability of embryos cultured by use of glucose instead of pyruvate and lactate after the ferilization may be due to the rise in ROS generation in Day 1 embryos. Moreover, results from this study suggest that the concentration of glucose in the medium that can be used by the Day 1-2 embryos is limited to 3.5 mM and exposure to higher glucose concentrations does not improve embryo development.
Thirteenth International Conference on Thermoelectrics (1995)

These proceedings represent papers presented at the 13th International Conference on thermoelectrics sponsored by the International Thermoelectric Society (ITS). The conference represented a forum for the exchange of recent research within the thermoelectric field and covered topics ranging from high temperature materials and applications to those of room/low temperature materials and applications. The synthesis of materials and physical properties were covered as well as thermoelectric power generation and thermoelectric heating/cooling applications. There were 75 papers presented and compiled in these proceedings and all have been abstracted for the Energy Science and Technology database. (AIP)
Grøstl - a SHA-3 candidate (2009)

Grøstl is a SHA-3 candidate proposal. Grøstl is an iterated hash function with a compression function built from two fixed, large, distinct permutations. The design of Grøstl is transparent and based on principles very different from those used in the SHA-family. The two permutations are constructed using the wide trail design strategy, which makes it possible to give strong statements about the resistance of Grøstl against large classes of cryptanalytic attacks. Moreover, if these permutations are assumed to be ideal, there is a proof for the security of the hash function. Grøstl is a byte-oriented SP-network which borrows components from the AES. The S-box used is identical to the one used in the block cipher AES and the diffusion layers are constructed in a similar manner to those of the AES. As a consequence there is a very strong confusion and diffusion in Grøstl. Grøstl is a so-called wide-pipe construction where the size of the internal state is significantly larger than the size of the output. This has the effect that all known, generic attacks on the hash function are made much more difficult. Grøstl has good performance on a wide range of platforms and counter-measures against side-channel attacks are well-understood from similar work on the AES.
Immunological evaluation of <i>Escherichia coli</i>‐derived hepatitis C virus second envelope protein (E2) variants (2001)

Two variants of the hepatitis C virus (HCV) E2 envelope protein, lacking the C-terminal domain and comprising amino acids 458-650 (E2A) and 382-605 (E2C), respectively, were efficiently produced in BL21 (DE3) Escherichia coli cells. E2A and E2C were used to immunize mice. The E2C variant induced the maximal mean antibody titer. Anti-E2C mouse sera reacted mainly with E2 synthetic peptides covering the 70 amino acid N-terminal region of the E2 protein. Moreover, a panel of anti-HCV positive human sera recognized only the E2C protein (28.2%) and the synthetic peptide covering the HVR-1 of the E2 protein (23.1%). These data indicate the existence of an immunologically relevant region in the HVR-1 of the HCV E2 protein.
Synthesis, Growth Mechanism, and Electrochemical Properties of Hollow Mesoporous Carbon Spheres with Controlled Diameter (2011)

Hollow mesoporous carbon spheres with controllable diameters have been fabricated from core–shell structured mesoporous silica sphere templates using chemical vapor deposition (CVD). By controlling the thickness of the silica shell, hollow carbon spheres with different diameters are obtained. The use of ethylene as the carbon precursor produces mesoporous graphitic hollow carbon spheres. The hollow carbon spheres have a relatively large degree of graphitization together with good meso-structural order and high specific surface area of 771 m2/g. The mechanism governing the formation of the hollow spheres is studied, and the importance of the surfactant (CTAB) is also clarified. CTAB accelerates the carbon deposition process, thus improving the product yield. These hollow carbon spheres that have good electrochemical properties are suitable for lithium ion batteries.
Gold Nanoparticle Assisted Assembly of a Heme Protein for Enhancement of Long-Range Interfacial Electron Transfer (2007)

Interfacial electron transfer (ET) of biological macromolecules such as metalloproteins is the key process in bioelectrochemistry, enzymatic electrocatalysis, artificial ET chains, single-molecule electronic amplification and rectification, and other phenomena associated with the area of bioelectronics. A key challenge in molecular bioelectronics is to improve the efficiency of long-range charge transfer. The present work shows that this can be achieved by nanoparticle (NP) assisted assembly of cytochrome c (cyt c) on macroscopic single-crystalline electrode surfaces. We present the synthesis and characterization of water-soluble gold nanoparticles (AuNPs) with core diameter 3−4 nm and their application for the enhancement of long-range interfacial ET of a heme protein. Gold nanoparticles were electrostatically conjugated with cyt c to form nanoparticle−protein hybrid ET systems with well-defined stoichiometry. The systems were investigated in homogeneous solution and at liquid/solid interface. Conjugation of cyt c results in a small but consistent broadening of the nanoparticle plasmon band. This phenomenon can be explained in terms of long-range electronic interactions between the gold nanoparticle and the protein molecule. When the nanoparticle−protein conjugates are assembled on Au(111) surfaces, long-range interfacial ET across a physical distance of over 50 Å via the nanoparticle becomes feasible. Moreover, significant enhancement of the interfacial ET rate by more than an order of magnitude compared with that of cyt c in the absence of AuNPs is observed. AuNPs appear to serve as excellent ET relays, most likely by facilitating the electronic coupling between the protein redox center and the electrode surface.
MAQAO: Modular assembler quality Analyzer and Optimizer for Itanium 2 (2005)

International audience
High resolution digital holographic synthetic aperture applied to deformation measurement and extended depth of field method (2010)

This paper discusses the potential of the synthetic-aperture method in digital holography to increase the resolution, to perform high accuracy deformation measurement, and to obtain a three-dimensional topology map. The synthetic aperture method is realized by moving the camera with a motorized x-y stage. In this way a greater sensor area can be obtained resulting in a larger numerical aperture (NA). A larger NA enables a more detailed reconstruction combined with a smaller depth of field. The depth of field can be increased by applying the extended depth of field method, which yields an in-focus reconstruction of all longitudinal object regions. Moreover, a topology map of the object can be obtained.
On the Formation of Cubic Phases (1999)

Abstract Ever since the report of the Sm phase by Gray in biphenylcarboxylic acids,[1] there has been interest in what was termed the smectic D phase, and what we now know of as the cubic phase (Cub). A recent review of the subject by Diele has collected together very many of the compounds known to show such phases and has looked at structural types. [2]
SYMPOSIUM INTERNATIONAL SUR LES GRANULATS, NICE, 21-23 MAI 1984 - THEME III - ESSAIS DE GRANULATS (1984)

CE THEME COMPORTE LES COMMUNICATIONS SUIVANTES : RAPPORT GENERAL (REZNAK,L) ; DURABILITE DES GRANULATS : L'ESSAI AU SULFATE (AUBERTIN,M - LAROCHELLE,F) ; CORRELATIONS ENTRE LES PROPRIETES PHYSICOMECANIQUES DES ROCHES ET LE COMPORTEMENT DES GRANULATS MANUFACTURES (BALLIVY,G - DAYRE,M) ; PREVISION DE LA TENEUR EN FINES DES SABLES DE CONCASSAGE (CARDON,D - EURARD,H - GARNIER,J) ; RESISTANCE TO POLISHING OF ROADMAKING AGGREGATES FROM BULGARIA (DASKALOVA,L) ; QUALITY VARIATIONS IN WHIN SILL AGGREGATES FROM NORTHUMBERLAND, ENGLAND (DEARMAN,WR - IRFAN,Y - MONEY,MS - TURK,N - HUSSEN,TI) ; DETERMINATION DU COEFFICIENT D'ECOULEMENT DES GRAVILLONS (GARNIER,J - ROBERT,J - CAMPANAC,R) ; PREDICTION OF AGGREGATE AND PAVEMENT POLISHING (HENRY,JJ - MEYER,WE) ; INFLUENCE DE LA PETROGRAPHIE SUR LES CARACTERISTIQUES PHYSIQUES ET MECANIQUES DE GRANULATS CALCAIRES DE LORRAINE (HOMAND-ETIENNE,F - TROALEN,JP) ; STATISTICAL METHODS OF AGGREGATE DURABILITY EVALUATION (HUDEC,PP) ; QUANTITATIVE PETROGRAPHIC ANALYSIS OF AGGREGATE (HUDEC,PP). (VOIR FICHE GENERALE DIRR 117595 ET FICHES SUR CE THEME 117603 ET 117604).
Surface second-harmonic generation from two interfaces of polyimide film coated on a substrate (1997)

Side chain orientation of polyimide (PI) films for liquid crystal alignment has been studied by surface second-harmonic generation (SHG). SHG from two interfaces of the film was separately observed using thick films, in which SH light from the rear interface was almost absorbed in the film. For as-coated films, the average tilt angle of the side chain at the air-PI interface is smaller than that of the other interface. Rubbing action caused in-plane anisotropy only for the air-PI interface. The distribution function of the side chain of the rubbed PI film was also discussed.
Thermoelectric Properties of Combustion Synthesized and Spark Plasma Sintered Sr<SUB>1&minus;<I>x</I></SUB>R<I><SUB>x</SUB></I>TiO<SUB>3</SUB> (R = Y, La, Sm, Gd, Dy, 0<<I>x</I>&le;0.1) (2007)

Thermoelectric properties of combustion synthesized and spark plasma sintered rare-earth-doped (Y, La, Sm, Gd and Dy) SrTiO3 was investigated from room temperature to 870 K toward the viewpoint of energy and time saving without deterioration in thermoelectric properties. All the rare-earth-doped SrTiO3 were successfully synthesized and sintered with high purities and high densities. With temperature increasing, the absolute value of Seebeck coefficient increased and the electric conductivity decreased; the power factor of all the samples decreased except Y-doped sample in the experimental temperature range. In all the samples, the La-doped SrTiO3 and the Y-doped SrTiO3 had the highest and the lowest power factor, respectively. The dimensionless figure of merit ZT of La-doped samples with different doping amount was evaluated and the maximum ZT was 0.22, which was obtained at 800 K from Sr0.92La0.08TiO3 sample. Comparing Y and La-doped samples prepared by our method with that of conventional solid-state reaction method, the thermoelectric properties of our samples were relatively higher. Thus the combination of combustion synthesis and spark plasma sintering has a potential to prepare perovskite-oxide materials with relatively higher thermoelectric properties for high-temperature application.
Gender differences in the effect of anesthesiology on death during surgical procedures (2013)

Rosinia, F.; Lefante, J.; Diana, M. A.; Freyder, L.; Liu, H.; Webber, L. Author Information
Different indications, warnings and precautions, and contraindications for the same drug—an international comparison of prescribing information for commonly used psychiatric drugs (2012)

This substantial variation in key prescribing information across countries highlights the need for a better international cooperation and standardization of prescribing information.
Recent Progress on Cosmetic Raw Materials (1989)

Recent trend of the development of cosmetic raw materials has its importance in finding function and efficacy for skin. We discuss about cosmetic raw materials such as oil, humectant, surfactant and pigment in related to their function and efficacy in this review.
Non-local dual image denoising (2014)

The current state-of-the-art non-local algorithms for image denoising have the tendency to remove many low contrast details. Frequency-based algorithms keep these details, but on the other hand many artifacts are introduced. Recently, the Dual Domain Image Denoising (DDID) method has been proposed to address this issue. While beating the state-of-the-art, this algorithm still causes strong frequency domain artifacts. This paper reviews DDID under a different light, allowing to understand their origin. The analysis leads to the development of NLDD, a new denoising algorithm that outperforms DDID, BM3D and other state-of-the-art algorithms. NLDD is also three times faster than DDID and easily parallelizable.
Gene expression analysis of interferon-β treatment in multiple sclerosis (2008)

Treatment with interferon-beta (IFN-beta) induces the expression of hundreds of genes in blood mononuclear cells, and the expression of several genes has been proposed as a marker of the effect of treatment with IFN-beta. However, to date no molecules have been identified that are stably induced by treatment with IFN-beta. We use DNA microarrays to study gene expression in 10 multiple sclerosis (MS) patients who began de novo treatment with IFN-beta. After the first injection of IFN-beta, the expression of 74 out of 3428 genes changed at least two-fold and statistically significantly (after Bonferroni correction). In contrast, we observed no persisting effects of IFN-beta on gene expression. Among the most strongly induced genes was MXA, which has been used in previous biomarker studies in MS. In addition, the study identified the induction of LGALS9 and TCIR1G, involved in negative regulation of T helper type I immunity and T-cell activation, as novel effects of IFN-beta therapy in MS.
ChemInform Abstract: Synthesis and Inhibitory Effects on Platelet Aggregation of 3‐(2‐ Thienyl)‐ and 3‐(1‐Imidazolyl)‐1,2‐benzisoxazole Derivatives. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
TAB4 Stimulates TAK1-TAB1 Phosphorylation and Binds Polyubiquitin to Direct Signaling to NF-κB (2008)

Responses to transforming growth factor beta and multiple cytokines involve activation of transforming growth factor beta-activated kinase-1 (TAK1) kinase, which activates kinases IkappaB kinase (IKK) and MKK3/6, leading to the parallel activation of NF-kappaB and p38 MAPK. Activation of TAK1 by autophosphorylation is known to involve three different TAK1-binding proteins (TABs). Here we report a protein phosphatase subunit known as type 2A phosphatase-interacting protein (TIP) that also acts as a TAB because it co-precipitates with and directly binds to TAK1, enhances TAK1 autophosphorylation at unique sites, and promotes TAK1 phosphorylation of IKKbeta and signaling to NF-kappaB. Mass spectrometry demonstrated that co-expression of TAB4 protein significantly increased phosphorylation of four sites in TAK1, in a linker region between the kinase and TAB2/3 binding domains, and two sites in TAB1. Recombinant GST-TAB4 bound in an overlay assay directly to inactive TAK1 and activated TAK1 but not TAK1 phosphorylated in the linker sites, suggesting a bind and release mechanism. In kinase assays using TAK1 immune complexes, added GST-TAB4 selectively stimulated IKK phosphorylation. TAB4 co-precipitated polyubiquitinated proteins dependent on a Phe-Pro motif that was required to enhance phosphorylation of TAK1. TAB4 mutated at Phe-Pro dominantly interfered with IL-1beta activation of NF-kappaB involving IKK-dependent but not p38 MAPK-dependent signaling. The results show that TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK1-TAB1, which activates IKK signaling to NF-kappaB.
Automated design of tailored link prediction heuristics for applications in enterprise network security (2019)

The link prediction problem, which involves determining the likelihood of a relationship between objects, has numerous applications in the areas of recommendation systems, social networking, anomaly detection, and others. A variety of link prediction techniques have been developed to improve predictive performance for different application domains. Selection of the appropriate link prediction heuristic is critical which demonstrates the need for tailored solutions. This work explores the use of hyper-heuristics to automate the selection and generation of customized link prediction algorithms. A genetic programming approach is used to evolve novel solutions from functionality present in existing techniques that exploit characteristics of a specific application to improve performance. Applications of this approach are tested using data from a real-world enterprise computer network to differentiate normal activity from randomly generated anomalous events. Results are presented that demonstrate the potential for the automated design of custom link prediction heuristics that improve upon the predictive capabilities of conventional methods.
The Synthesis of 10-[Spiro[6,6]C60]-Anthrone: A Microscale Reaction of Fullerene (1996)

The microscale 1,3-dipolar cycloaddition reaction of Fullerene-C60 with 10-diazoanthrone leading to the methanofullerene adduct is described. The synthesis of the monoadduct and flash chromatography separation of the formed bisadducts was set up for two three hour laboratory periods.
Numerical Modelling of C. elegans L1 Aggregation (2018)

We attempt to explain the aggregation behavior of starved C. elegans L1s (Artyukhin et al., 2015) by a variation of the Keller-Segel chemotaxis model (1970). Each worm releases a diffusible, unstable attractant. The worms chemotax towards the attractant. By using a continuous density function to approximate the spatial distribution of worms, behavior may be described by a nonlinear system of partial differential equations. To determine whether such a model can account for C. elegans L1 behavior, we solve this PDE system numerically. In the original Keller-Segel model, density is unbounded, leading to unrealistic results. We modified the model in such a way as to limit the maximum density. We also developed numerical methods designed to work well near equilibrium. With these changes our model can reproduce some but not all aspects of the behavior.
Real-time distributed simulation using the Modular Modeling System interfaced to a Bailey NETWORK 90 system (1991)

The Modular Modeling System was adapted for real-time simulation testing of diagnostic expert systems in 1987. The early approach utilized an available general purpose mainframe computer which operated the simulation and diagnostic program in the multitasking environment of the mainframe. That research program was subsequently expanded to intelligent distributed control applications incorporating microprocessor based controllers with the aid of an equipment grant from the National Science Foundation (NSF). The Bailey NETWORK 90 microprocessor-based control system, acquired with the NSF grant, has been operational since April of 1990 and has been interfaced to both VAX mainframe and PC simulations of power plant processes in order to test and demonstrate advanced control and diagnostic concepts. This paper discusses the variety of techniques that have been used and which are under development to interface simulations and other distributed control functions to the Penn State Bailey system.