gebhart/patrepeval huggingface dataset:
Abstract 3787: Effects of Running Exercise on Aortic Telomere Regulating Proteins, Survival Pathways and Apoptosis (2008)

Background: The vasoprotective effects of physical exercise are only partially understood on the molecular level. Telomere-associated proteins affect cellular senescence and survival. We studied the molecular effects of physical exercise in aortic tissue of running and sedentary mice. Methods: C57/Bl6 wildtype, endothelial nitric oxide synthase (ENOS) deficient and telomerase reverse transcriptase (TERT) deficient mice were randomized to voluntary running or no running wheel conditions (n=8 –10 per group). Results: Physical exercise for 3 weeks upregulated aortic telomerase activity to 303 ± 32% (p<0.01) of sedentary controls, increased protein expression telomere-repeat binding factor (TRF) 2 (254 ± 35%, p<0.05) and reduced protein expression of the senescence / apoptosis regulators Chk2 (41 ± 12%), p53 (51 ± 12%) and p16 (64 ± 19%). Running increased mRNA expression of TRF1 (193 ± 50%), TRF2 (192 ± 14%) and of the repair protein Ku70 (365 ± 121%). These exercise-induced changes were absent in ENOS −/− and TERT −/− mice. Aortic telomere length as determined by quantitative fluorescence in-situ hybridization (QFISH) did not differ between 3 week and 6 months old sedentary or running mice (1914 ± 166 vs. 1762 ± 394 telomere fluorescence units, TFU), but was lower in 18 months old sedentary control mice (1142 ± 117 TFU, p<0.05). To test the physiologic relevance of these exercise-mediated anti-senescent pathways, vascular oxidative stress was induced in-vivo by intraperitoneal injection of 25mg/kg paraquat for 24 hours before quantification of endothelial apoptosis in the thoracic aorta. Compared to sedentary mice, paraquat increased apoptotic cell death to 581 ± 48 %, whereas apoptosis was significantly lower in mice preconditioned by 21 days voluntary exercise (320 ± 34%, p<0.001 vs. control and paraquat). Conclusions: Voluntary physical activity upregulates aortic telomere regulating proteins which induces anti-senescent and anti-apoptotic effects mediated by ENOS and TERT independent of telomere length.
Large gap plasma display cell with auxiliary electrodes: macro-cell experiments and two-dimensional modelling (2003)

International audience
Polymerization of Naphthalene by the Use of Anhydrous Aluminum Chloride (1974)

ナフタレンを塩化アルミニウム触媒を用いて,90～160℃,O.5～2時間の範囲で重縮合反応を行ない,反応生成物を得た。反応温度の高いほど,反応時間の長いほどさらに触媒量が多いほど,高収率で生成物が得られた。生成物および生成物からn-ヘキサン,ベンゼンを用いて分別した分別物,レジン(n-ヘキサン可灘物),アスファルテン(n-ヘキサン不溶,ベンゼン可溶物)のNMRおよびIRスペクトルは類似しており,両者の化学構造が類似していることを示唆している。反応条件が異なっても,レジγ,アスフアルテンは類似の平均分子量を有し,平均重合度はレジンがナフタレンの2.3～2.9量体,アスファルテンが3.2～4.1量体程度であった。IRおよびNMRスペクトルから生成物およびレジン,アスファルテンには,一部脂環構造が存在することが認められた。さらに三量体以上の生成物はナフタレンの2,6-位で結合しているものと推察された。
Assessing Ultrafiltration performance problems (2004)

Using membrane autopsy, foulant analyses, and related cleaning studies in assessing reverse osmosis membrane fouling is well known. Fouling in Ultrafiltration (UF) and microfiltration (MF) membranes, however, with their multiple configurations, membrane material compositions, and filtration applications, is more difficult to determine. Nalco's Michael Kamrath and Deepak Musale show how autopsies of tubular and hollow fibre UF membranes - as well as a cleaning study on a tubular membrane - can help identify and solve such fouling problems.
A DISPERSED FLUORESCENCE DATA SET FOR THE $\tilde{X}$ STATE OF ACETYLENE: AN APPROACH TOWARD MULTIDIMENSIONAL VIBRATIONAL SPECTROSCOPY (1997)

Author Institution: Department of Chemistry, MIT
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome (2009)

Down syndrome (DS) children have a unique genetic susceptibility to develop leukemia, in particular, acute megakaryocytic leukemia (AMkL) associated with somatic GATA1 mutations. The study of this genetic susceptibility with the use of DS as a model of leukemogenesis has broad applicability to the understanding of leukemia in children overall. On the basis of the role of GATA1 mutations in DS AMkL, we analyzed the mutational spectrum of GATA1 mutations to begin elucidating possible mechanisms by which these sequence alterations arise. Mutational analysis revealed a predominance of small insertion/deletion, duplication, and base substitution mutations, including G:C>T:A, G:C>A:T, and A:T>G:C. This mutational spectrum points to potential oxidative stress and aberrant folate metabolism secondary to genes on chromosome 21 (eg, cystathionine-beta-synthase, superoxide dismutase) as potential causes of GATA1 mutations. Furthermore, DNA repair capacity evaluated in DS and non-DS patient samples provided evidence that the base excision repair pathway is compromised in DS tissues, suggesting that inability to repair DNA damage also may play a critical role in the unique susceptibility of DS children to develop leukemia. A model of leukemogenesis in DS is proposed in which mutagenesis is driven by cystathionine-beta-synthase overexpression and altered folate homeostasis that becomes fixed as the ability to repair DNA damage is compromised.
[An elderly patient with myelodysplastic syndrome successfully treated with combination of granulocyte-colony stimulating factor and continuous-drip infusion of low-dose cytarabine and etoposide]. (2000)

A 73-year-old man was given a diagnosis of myelodysplastic syndrome in October 1997. He was treated with red blood cell transfusion and granulocyte-colony stimulating factor (G-CSF). In February 1998, he was admitted due to progression of pancytopenia. Bone marrow aspiration revealed refractory anemia with excess of blasts in transformation. The patient was treated with continuous-drip infusion of low-dose cytarabine and etoposide with G-CSF (AVG therapy). Complete remission (CR) was obtained after 2 courses of AVG therapy. Non-hematologic adverse effects were mild enough to be tolerated. CR has been maintained for 16 months with 1 course of consolidation therapy and 3 courses of intensification therapy using the AVG regimen.
Design of electromagnetic sensor arrays optimised for inversion of the magnetic polarisability tensor (2015)

This paper presents a method for the simulation of sensitivity maps from an array of coils. Some of the criteria necessary for designing a coil array capable of inversion of the magnetic polarisability are examined, and sensitivity maps are analysed with this in mind. The summarised sensitivity map for a single optimised array is presented, as well as the results of noise testing of an inversion algorithm using simulated measurements. Finally, a method for the construction and testing of such an array is presented.
CoSe<sub>2</sub>-Decorated NbSe<sub>2</sub> Nanosheets Fabricated via Cation Exchange for Li Storage (2018)

Though 2D transition metal dichalcogenides have attracted a lot of attention in energy-storage applications, the applications of NbSe<sub>2</sub> for Li storage are still limited by the unsatisfactory theoretical capacity and uncontrollable synthetic approaches. Herein, a controllable oil-phase synthetic route for preparation of NbSe<sub>2</sub> nanoflowers consisted of nanosheets with a thickness of ∼10 nm is presented. Significantly, a part of NbSe<sub>2</sub> can be further replaced by orthorhombic CoSe<sub>2</sub> nanoparticles via a post cation exchange process, and the predominantly 2D nanosheet-like morphology can be well-maintained, resulting in the formation of CoSe<sub>2</sub>-decorated NbSe<sub>2</sub> (denoted as CDN) nanosheets. More interestingly, the CDN nanosheets exhibit excellent lithium-ion battery performance. For example, it achieves a highly reversible capacity of 280 mAh g<sup>-1</sup> at 10 A g<sup>-1</sup> and long cyclic stability with specific capacity of 364.7 mAh g<sup>-1</sup> at 5 A g<sup>-1</sup> after 1500 cycles, which are significantly higher than those of reported pure NbSe<sub>2</sub>.
Thermal characteristics of edge-illumination type LED backlight system in a thin flat panel display (2010)

Light Emitting Diode (LED) is one of promising source in lighting industry and applied as light source of a backlight system in flat panel display with advantages of performance and environmental-friendly feature. The inherent characteristic of LED causes high heat dissipation from the device and careful thermal management is required. Therefore, the thermal management in LED backlight system is crucial for the display development. However, narrow volume of flat panel display cause non-uniform temperature distribution over the system and the dependency of LED operating temperature necessitate the carful thermal design for light source. The objective of present study aimed to investigate the effect of design parameters in edge illuminating type backlight system. It is presented thermal characteristics of LED light source in edge-illumination type backlight system and evaluated performance of the thermal management system to ensure the reliability of the system.
Reactions of Bis(pentafluorophenyl)borane with Cp<sub>2</sub>Ta(CH<sub>2</sub>)CH<sub>3</sub>:  Generation and Trapping of Tantalocene Borataalkene Complexes (2001)

Reaction of Cp2Ta(CH2)3 with 2 equiv of HB(C6F5)2 results in production of the dihydride Cp2Ta(CH2B(C6F5)2)(μ-H)(H), 1, plus 1 equiv of H3CB(C6F5)2. The pathway to 1 involves stepwise attack of borane first at the methylene group, followed by attack at the methyl group, which undergoes alkyl/hydride exchange with the second equivalent of HB(C6F5)2. The product of HB(C6F5)2 addition to the methylene ligand, methyl hydride complex Cp2Ta(CH2B(C6F5)2)(μ-H)(CH3), 2, can be intercepted by carrying out the reaction in hexane at low temperature, a medium in which it is nearly totally insoluble. This complex eliminates methane at higher temperatures in a first-order decomposition process (ΔH⧧ = 20.4(5) kcal mol-1 and ΔS⧧ = −2.0(2) cal mol-1 K-1). The product, a borataalkene complex formulated as Cp2Ta[CH2B(C6F5)2], 3, is unstable and cannot be isolated. DFT calculations support its formulation and show that it is present as a singlet/triplet mixture, accounting for the observed paramagnetism of solutions containing 3. While 3 cannot be isolated or spectroscopically probed, it can be trapped if 2 is allowed to decompose in the presence of tBuNC or CO, giving the products Cp2Ta[η2-CH2B(C6F5)2](L) (L = tBuNC, 4; CO, 5). Both of these compounds have been structurally characterized, and the structural and spectroscopic data for these compounds support an η2 bonding description for the borataalkene ligand which is reminiscent of the commonly held Dewar−Chatt−Duncanson model for alkene bonding to transition metals. DFT calculations on 5 and the model complex Cp2Ta[η2-CH2BH2](CO), 6, provide further support for this description. The facile conversion of this ligand from an η2 to an η1 bonding mode is proposed to account for some H/D exchange processes observed in both dihydride 1 and methyl hydride complex 2. Plausible mechanisms for both of these processes are proposed.
Comparative chemical analyses of the alloantigenic fragments of HL-A antigens. (1976)

Papain-solubilized HL-A antigens have been shown to contain two polypeptide fragments: beta2-micro-globulin with a molecular weight of approximately 12,000 and a larger fragment with a molecular weight of about 34,000. The large fragments isolated from two HL-A preparations carrying different specificities appeared homogeneous both by immunoelectrophoresis and sodium dodecyl sulfate-acrylamide electrophoresis. Both HL-A antigen preparations contained the same NH2-terminal (glycine) and the same COOH-terminal residue (serine). The carbohydrate content of the large fragment was 12.9%, making the carbohydrate-free molecular weight approximately 30,000. Small but significant differences have been found in the amino acid compositions and tryptic peptide maps of the two large fragments containing different specificities.
Investigations on Lignin and Lignification. X. The Isolation and Characterization of the Native Lignin from Kiri Wood (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigations on Lignin and Lignification. X. The Isolation and Characterization of the Native Lignin from Kiri WoodGeorge de Stevens and F. F. NordCite this: J. Am. Chem. Soc. 1952, 74, 13, 3447–3448Publication Date (Print):July 1, 1952Publication History Published online1 May 2002Published inissue 1 July 1952https://pubs.acs.org/doi/10.1021/ja01133a532https://doi.org/10.1021/ja01133a532research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the correlation structure of unilateral AR processes on the plane (2000)

In, Tory and Pickard show that a simple subclass of unilateral AR processes identifies with Gaussian Pickard random fields on Z 2 . First, we extend this result to the whole class of unilateral AR processes, by showing that they all satisfy a Pickard-type property, under which correlation matching and maximum entropy properties are assessed. Then, it is established that the Pickard property provides the ‘missing’ equations that complement the two-dimensional Yule-Walker equations, in the sense that the conjunction defines a one-to-one mapping between the set of AR parameters and a set of correlations. It also implies Markov chain conditions that allow exact evaluation of the likelihood and an exact sampling scheme on finite lattices.
Abnormality detection in noisy biosignals (2013)

Although great strides have been achieved in computer-aided diagnosis (CAD) research, a major remaining problem is the ability to perform well under the presence of significant noise. In this work, we propose a mechanism to find instances of potential interest in time series for further analysis. Adaptive Kalman filters are employed in parallel among different feature axes. Lung sounds recorded in noisy conditions are used as an example application, with spectro-temporal feature extraction to capture the complex variabilities in sound. We demonstrate that both disease indicators and distortion events can be detected, reducing long time series signals into a sparse set of relevant events.
Advanced Communication Tools and a Qualitative Research to Complement Epidemiological Study (2009)

ISEE-0767 Background and Objective: A qualitative research through advanced communication tools have been included in an epidemiological human biomonitoring (HBM) study in 16 municipalities of Campania Region, Italy (SEBIOREC), the area is experiencing a waste crisis and a diffuse pollution due to illegal dumping since ’90. Objectives: Contribute qualitative insights for interpreting epidemiological data; facilitate stakeholders comprehension of meaning and implication of HBM and of environment-health relationships. Methods: A field research based on narrative interviews was developed focusing on: perception of pollution and its consequences on people; trust towards authorities and scientists; food consumption, change of habits and occupational and environmental exposure profile. The study questionnaire prepared to interpret HBM included a section on risk perception and information sources (section 11). Seminars and focus groups are in progress for supporting interpretation of HBM results and preparing communication tools, involving the SEBIOREC researchers. Monitoring of communication activities by a specific experts group is in progress. Results: SEBIOREC analysis of 910 blood and breast milk samples to detect dioxins and metals is ongoing. Questionnaire-section 11 analysis showed that the most dangerous perceived problems for individual exposure were: air and waste pollution (84% and 83%), industries (77%), earthquake (67%); information resulted mainly covered by National (31%) and Local TV (14%) among six multiple answers; low trust towards institutions and associations was identified. Eighty interviews to selected representatives, for 120 recorded hours, were carried out. The results show a complex picture, where people are experiencing difficulties in establishing connections between people and environment, are losing trust in the future, are building relationships at a local level based on affectivity, are often consuming local food and water. Conclusion: Understanding risk perception and knowledge of residents in a highly polluted area, including one where illegal waste dumping is common, is crucial to properly interpret and release results of HBM studies to donors, administrators and the community.
Correction: Abnormal Contextual Modulation of Visual Contour Detection in Patients with Schizophrenia (2013)

Schizophrenia patients demonstrate perceptual deficits consistent with broad dysfunction in visual context processing. These include poor integration of segments forming visual contours, and reduced visual contrast effects (e.g. weaker orientation-dependent surround suppression, ODSS). Background image context can influence contour perception, as stimuli near the contour affect detection accuracy. Because of ODSS, this contextual modulation depends on the relative orientation between the contour and flanking elements, with parallel flankers impairing contour perception. However in schizophrenia, the impact of abnormal ODSS during contour perception is not clear. It is also unknown whether deficient contour perception marks genetic liability for schizophrenia, or is strictly associated with clinical expression of this disorder. We examined contour detection in 25 adults with schizophrenia, 13 unaffected first-degree biological relatives of schizophrenia patients, and 28 healthy controls. Subjects performed a psychophysics experiment designed to quantify the effect of flanker orientation during contour detection. Overall, patients with schizophrenia showed poorer contour detection performance than relatives or controls. Parallel flankers suppressed and orthogonal flankers enhanced contour detection performance for all groups, but parallel suppression was relatively weaker for schizophrenia patients than healthy controls. Relatives of patients showed equivalent performance with controls. Computational modeling suggested that abnormal contextual modulation in schizophrenia may be explained by suppression that is more broadly tuned for orientation. Abnormal flanker suppression in schizophrenia is consistent with weaker ODSS and/or broader orientation tuning. This work provides the first evidence that such perceptual abnormalities may not be associated with a genetic liability for schizophrenia.
A Generalized Construction and Improvements on Nonbinary Codes From Goppa Codes (2013)

We present an efficient construction of extended length Goppa codes. Using this construction, we obtain 78 new nonbinary codes with better minimum distance than the previously known codes with the same length and dimension. The construction is based on the observation that certain Goppa codes can be seen as BCH codes.
The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol. (2007)

Adaptogens possess anti-fatigue and anti-stress activities that can increase mental and physical working performance against a background of fatigue or stress. The aim of the present study was to ascertain which mediators of stress response are significantly involved in the mechanisms of action of adaptogens, and to determine their relevance as biochemical markers for evaluating anti-stress effects in rabbits subjected to restraint stress. Blood levels of stress-activated protein kinase (SAPK/JNK), the phosphorylated kinase p-SAPK/p-JNK, nitric oxide (NO), cortisol, testosterone, prostaglandin E(2), leukotriene B(4) and thromboxane B(2) were determined in groups of animals prior to daily oral administration of placebo, rhodioloside or extracts of Eleutherococcus senticosus, Schizandra chinensis, Rhodiola rosea, Bryonia alba and Panax ginseng over a 7 day period. Ten minutes after the final treatment, animals were immobilized for 2 hours and blood levels of the markers re-determined. In the placebo group, only p-SAPK/p-JNK, NO and cortisol were increased significantly (by 200-300% cf basal levels) following restraint stress, whilst in animals that had received multiple doses of adaptogens/stress-protectors, the levels of NO and cortisol remained practically unchanged after acute stress. Rhodioloside and extracts of S. chinensis and R. rosea were the most active inhibitors of stress-induced p-SAPK/p-JNK. E. senticosus, B. alba and P. ginseng exerted little effect on p-SAPK/p-JNK levels. It is suggested that the inhibitory effects of R. rosea and S. chinensis on p-SAPK/p-JNK activation may be associated with their antidepressant activity as well as their positive effects on mental performance under stress.
Efficient algorithms and structures for lagged least squares (LS) FIR filters in the case of prewindowed signals (2005)

The purpose of this paper is to provide a brief overview of the algorithms and structures which can be used in connection with ℓ - lag FIR filtering. A number of existing efficient algorithms from the zero - lag problem are generalized here, to be applied to the ℓ - lag case. Both direct and lattice - ladder structures are considered. Four different families of techniques are discussed: time recursive, order recursive, lattice - ladder and "recursive in lag". The unified approach used in this paper for the derivation of the algorithms permits the underlining of the relationships among the variables appearing in the four families of recursive schemes discussed. The "prewindowing" assumption is used throughout.
Two distinct dihydroflavonol 4-reductases involved in anthocyanin biosynthesis in Gerbera Hybrids (2013)

Gerbera hybrids are important cut flowers sold worldwide. Beside carotenoids in yellow inflorescenses, they are known to synthesize various anthocyanins giving orange, red and pink colors. Different varieties accumulating either pelargonidin (Pg) or cyanidin (Cy) derivatives or even both together have been described. Dihydroflavonol 4-reductase (DFR) is known as the key enzyme in anthocyanin biosynthesis and a gene coding for the respective protein was cloned and functionally characterized in vitro and in planta from the pink variety “Regina” (1, 2). From these studies it became apparent that the recombinant protein accepts both, dihydrokaempferol (DHK) and dihydroquercetin (DHQ), as substrates enabling the synthesis of Pg and Cy derivatives, respectively. The availability of DHQ depends on the activity of flavonoid 3’-hydroxylase (F3’H), a membrane bound cytochrome P450 protein, which was also cloned and characterized from the same variety (3). Moreover, the genetics of this step is also described. However, in vivo inhibition of F3’H by applying the specific inhibitor tetcyclacis resulted in white segments of the Cy-line “Clivia” which led to the assumption that the DFR in this specific variety is not able to convert DHK into the precursors of Pg-derivatives and therefore has different catalytical characteristics compared to the “Regina” DFR.