gebhart/patrepeval huggingface dataset:
UTILIZAÇÃO DE CHOCOLATES RICOS EM POLIFENÓIS E COM AÇÃO ANTIOXIDANTE: BUSCA EM BASES DE PATENTES (2012)

The interest of researchers and producers in phenolic compounds, or polyphenols, due to the abundance in the human diet, the recognition of the antioxidant properties of these substances, and the probable role in prevention of various diseases associated with oxidative stress.Thus it has been increasing the targeting of research for the discovery of natural products with antioxidant activity, such as polyphenols, so that they act as functional foods.This study aims to provide research information developed on the evaluation of the polyphenols and antioxidant activity in chocolate, made up of different concentrations of cocoa liquor.Although there are few patents related to the use of chocolate as a source of phenolic antioxidants to the population.It is important then to clarify the effective concentration and concentrations which allow the effects expected from the food consumption information that is not in the scientific production obtained in the study.
ChemInform Abstract: A New Approach to Linear Tetracycles via Michael Reactions of Quinizarinquinone with O‐Silylated Ketene Acetals. (1987)

Abstract The quinone (I) and the acetal (II) form the adduct (III) which rearranges to give the products (IV) or (VI).
Immunostimulatory Effects of CpG-ODN upon Dendritic Cell-Based Immunotherapy in a Murine Model (2004)

s for the 19th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer, San Francisco, California, November 4-7, 2004: Dendritic Cells and Vaccines
Adaptive Channel Selection Through Collaborative Sensing (2006)

Proper channel selection is essential to exploit the benefits of multi-channel systems by distributing conflicting transmissions across non-interfering channels. Critical to channel selection is the channel quality metric. We propose a busy time ratio (BTR) metric that captures channel contention and user traffic load under a variety of network dynamics. We also propose a distributed collaborative sensing scheme to reduce sensing overhead and energy consumptions. The proposed algorithms can be implemented using conventional 802.11 hardware with single radio interface. The proposed metric can be integrated with routing and channel selection. Experimental results show that the proposed scheme significantly outperforms the existing channel selection methods.
Ancestral haplotypes reveal immunogenetics of IDDM the role of the central MHC in the (1992)

The major histocompatibility complex (MHC) contains multiple and diverse genes which may be relevant to the induction and regulation of autoimmune responses in insulin dependent diabetes mellitus (IDDM). In addi- tion to HLA class I and II, the possible candidates include TNF, C4, and several other poorly defined polymorphic genes in the central MHC region. This study describes two approaches which take advantage of the fact that the rele- vant genes are carried by highly conserved ancestral haplotypes such as 8.1 (HLA-B8, TNFS, C4AQO, C4B1, DR3, DQ2). First, three diabetogenic haplotypes (two Caucasoid and one Mongoloid) have been compared and it has been shown that all three share a rare allele of BAT3 as well as sharing DR3, DQ2. In 43 sequential patients with IDDM the cross product ratio for BAT3S was 4.8 (p<0.01) and 6.9 for HLA-B8 plus BAT3S (p<0.001). Second, partial or recombinant ancestral haplotypes with either HLA class I (HLA-B8) or II (HLA-DR3, DQ2) alleles were identified. Third, using haplotypic polymor- phisms such as the one in BAT3, we have shown that all the patients carrying recombinants of the 8.1 ancestral haplotype share the central region adjacent to HLA-B. These findings suggest that both HLA and non-HLA genes are involved in conferring susceptibility to IDDM, and that the region between HLA-B and BAT3 contains some of the relevant genes. By contrast, similar approaches sug- gest that protective genes map to the HLA class II region.
Inhibition of adenylate cyclase in adipocyte ghosts by the prostaglandin endoperoxide PGH2. (1976)

President Roosevelt thanks L. W. Hellrung for the photograph of Hellrung's sister's family. Roosevelt is proud of them as "American citizens" and sends his best wishes to her and her family.
Novel inversion approach to constrain plume sedimentation from tephra deposit data: Application to the 17 June 1996 eruption of Ruapehu volcano, New Zealand (2012)

We introduce a new inversion approach to constrain eruption source parameters and the distribution of tephra sedimentation from a weak plume. Our model is parameterized as a set of point sources along the plume base, whose trajectory is constrained by satellite and photographic images. Each point source releases tephra that is dispersed according to an advection‐diffusion equation. This dispersion process is expressed as a system of linear equations with nonlinear dependence on diffusivity and wind speed. We employ inversion techniques to estimate the tephra mass released by each point source as well as diffusivity, stabilizing the inversion by regularization. We apply our method to the Ruapehu eruption on 17 June, 1996 in New Zealand, which was characterized by a strongly wind‐advected plume that can be studied via tephra isomass measurements and particle size distributions at 119 locations. We demonstrate that the approach is feasible by performing analyses with real and synthetic data at a single grain size, and gain insight into the effects of data gaps, presence of noise, and nonlinear parameters on the inversion results. The best fit value of diffusivity yields tephra fallout that decreases steadily with distance to vent, and the predicted deposit is a good fit to the field measurements. This study illustrates the potential of a direct inversion approach to constrain diffusivity, as well as to recover the tephra fallout, without assuming a physical model for mass transport inside the plume.
High-Dose Chemotherapy with Busulfex and Melphalan As Conditioning Regimen Followed By Autologous STEM CELL Rescue for Pediatric Patients with High-Risk Neuroblastoma (2014)

High-dose chemotherapy with stem cell rescue (auto-transplant) became a well established consolidation procedure for high-risk neuroblastoma patients. We summarize our cumulative experience using busulfex and melphalan rather than carboplatin/etoposide/melphalan as preparative regimen for transplanting these pediatric patients.
Supplementary Feeding of Underweight, Stunted Malawian Children With a Ready-To-Use Food (2004)

RTUF is an acceptable alternative to maize and soy flour for dietary supplementation of moderately malnourished children. Approaches aimed at increasing the consumption of supplementary food by the selected recipients are needed.
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria (2014)

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.
A Dietary Supplement Attenuates IL-6 and CRP after Eccentric Exercise in Untrained Males (2003)

This study suggested that exercise-induced inflammation, evaluated by changes in IL-6 and CRP, was significantly reduced by the dietary supplement.
BIOCHEMICAL MARKERS AS A PREDICTOR FOR LYMPH-NODE INVOLVEMENT IN PATIENTS WITH CERVICAL-CANCER OF THE UTERUS (1994)

The present study was undertaken to assess the role of tumor associated urokinase-type plasminogen activator (uPA) and tumor infiltrating granulocyte-derived elastase as a positive and a negative predictor for lymph node involvement in patients with stage II cervical cancer of the uterus. uPA and uPA binding proteins (uPA receptors) were quantitated enzymologically and/or immunologically in cell membrane preparations obtained from cancer tissues. The cell membrane preparations express pro-uPA/uPA, uPA is bound to a specific type of surface receptors, of which more than 50% are saturated. Most of the receptor-bound uPA is enzymologically inactive pro-uPA. We have investigated the localization of pro-uPA/uPA and granulocyte elastase immunohistochemically and semiquantitated in formalin-fixed paraffin-embedded tissue sections in 13 patients with pelvic lymph node involvement and in 16 cases without lymph node involvement. Strong uPA staining was found in areas with invasive growth and degradation of surrounding normal tissue. A significant higher lymph node positive rate was observed in patients who had tumors with strong uPA staining than in those with weak staining (p<0.05). In contrast, phagocytic cells were found close to the tumor cells, and were located in aggregates or diffusely spread within tumor stroma surrounding the tumor nests. The inflammatory reaction seems to be most intense at the border between surrounding normal stromal cells and malignant epithelial cells. These cells produced and secreted granulocyte elastase.
REMOVAL OF SIALIC ACID FROM THE CELL COAT IN TUMOR CELLS AND VASCULAR ENDOTHELLUM, AND ITS EFFECTS ON METASTASIS (1962)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
OBTAINING ANTIOXIDANT COMPOUNDS SEED TAMARINDUS INDICA, SWEET VARIETY (2013)

The seeds of Tamarindus indica, sweet variety, are discarded without use of technology. The natural antioxidants can be found in in vegetables raw materials, therefore, the objective of this study was to obtain the seed extract and evaluation of their antioxidant activity (AA). The experiment was conducted using the linear outlining 2 2 + 3 repetitions at the center point, having CO2 as solvent, at pressures 100, 175 and 250 bar and temperatures 68, 95 and 122 F. In the condition of 250 bar and 122 F was used CO2 + ethanol at concentrations of 10, 25, 50 and 75%. The AA was assessed by the methods of DPPH and Folin-Ciocaltou. It was observed that by increasing the density, the higher the yield of extraction with pure CO2 due to the greater solvating power of the solvent, obtaining 2,6% 250bar/122 F. The increasing concentration of ethanol, 10 to 75%, contributed to a yield, respectively, from 3,47 to 20,3%, for it increased, the solubility of polar compounds. Increasing pressure and temperature favored the AA with pure CO2 from 28,2 to 53,9% (500μg/mL), but also the increasing ethanol concentration increased from 25,1 to 97,8% (500μg/mL). Phenolic compounds extracted with pure CO2 showed linear variation of 6,13 to 25,1 mgEAG/g extract, on condition of 100bar/68 F and 250bar/122 F, respectively. The ethanol contributed significantly to AA, being found of 25,6 to 420,8 mgEAG/g extract, 10 and 75%, respectively, this can be attributed to its chemical similarity to these compounds. The seed of the tamarind candy is potentially promising as a source of natural antioxidants.
P4‐114: Cerebrospinal Fluid Biomarkers of Neuronal Injury in Chronic Traumatic Brain Injury (2016)

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity around the world. It is becoming increasingly evident that TBI can lead to persistent, long-term debilitating effects, and in some cases, progressive neurodegeneration and chronic traumatic encephalopathy. Epidemiological studies suggest that a single mild-moderate TBI may be associated with accelerated neurodegeneration and increased risk of Alzheimer's disease. However, there are no objective tools to quantify whether these afflicted individuals have signs of neuronal injury. The main objective of this study was to determine whether chronic TBI is associated with elevated levels of biochemical markers for neuronal injury in cerebrospinal fluid. a prospective cohort study including Swedish professional ice hockey players whom following mTBI have had persistent post-concussive symptoms longer than 12 weeks or post-concussion syndrome (PCS). Twelve athletes with PCS and 12 nonathletic healthy controls were included. Biomarkers of cortical axonal injury, total tau (T-tau) and neurofilament light protein (NF-L) were analyzed in cerebrospinal fluid. The players had pathological Rivermead Postconcussion Symptoms Questionnairebut normal CT or MRI at inclusion. Players with PCS had elevated levels of CSF NF-L (mean +/- SD, 600 +/- 443 pg/mL) compared with controls (265 +/- 99 pg/mL; P = 0.035). There was no significant difference in the levels of T-tau (mean +/- SD, 202 +/- 63pg/mL) versus controls (178 +/- 58 pg/mL; P = 0.39). Our interim analysis of data from this study provides evidence that PCS is associated with neuronal injury, and analysis of NF-L in cerebrospinal fluid may help in medical counseling of athletes with PCS.
Observation of Beam-induced Abort Kicker Ferrite Heating in RHIC (2016)

During the FY 2013 RHIC polarized proton run, deterioration of the abort kicker system was observed. The reduced kicks resulted in quenching the superconducting quadrupole Q4 downstream of the beam dump. Frequent re-tuning of the modulator wave form temporarily mitigated the effect, which worsened during the course of the run. Beam-induced heating of the kicker ferrites was evenutally identified as the root cause of this behavior. We report our observations and discuss modifications to the kickers.
IgG4 Subclass-Specific Responses to Staphylococcus aureus Antigens Shed New Light on Host-Pathogen Interaction (2014)

IgG4 responses are considered indicative for long-term or repeated exposure to particular antigens. Therefore, studying IgG4-specific antibody responses against Staphylococcus aureus might generate new insights into the respective host-pathogen interactions and the microbial virulence factors involved. Using a bead-based flow cytometry assay, we determined total IgG (IgGt), IgG1, and IgG4 antibody responses to 40 different S. aureus virulence factors in sera from healthy persistent nasal carriers, healthy persistent noncarriers, and patients with various staphylococcal infections from three distinct countries. IgGt responses were detected against all tested antigens. These were mostly IgG1 responses. In contrast, IgG4 antibodies were detected to alpha-toxin, chemotaxis inhibitory protein of S. aureus (CHIPS), exfoliative toxins A and B (ETA and -B), HlgB, IsdA, LukD, -E, -F, and -S, staphylococcal complement inhibitor (SCIN), staphylococcal enterotoxin C (SEC), staphylococcal superantigen-like proteins 1, 3, 5, and 9 (SSL1, -3, -5, and -9), and toxic shock syndrome toxin 1 (TSST-1) only. Large interpatient variability was observed, and the type of infection or geographical location did not reveal conserved patterns of response. As persistent S. aureus carriers trended toward IgG4 responses to a larger number of antigens than persistent noncarriers, we also investigated sera from patients with epidermolysis bullosa (EB), a genetic blistering disease associated with high S. aureus carriage rates. EB patients responded immunologically to significantly more antigens than noncarriers and trended toward even more responses than carriers. Altogether, we conclude that the IgG4 responses against a restricted panel of staphylococcal antigens consisting primarily of immune modulators and particular toxins indicate important roles for these virulence factors in staphylococcal pathogen-host interactions, such as chronicity of colonization and/or (subclinical) infections.
A system for complex robotic welding (2002)

This paper presents the architecture of a system for robotic welding of complex tasks. The system integrates off‐line programming, control of redundant robots, collision‐free motion planning and sensor‐based control. An implementation for pipe structure welding made at Odense Steel Shipyard Ltd., Denmark, demonstrates the system can be used for automatic welding of complex products in one‐of‐a‐kind production.
Recommendations and Guidelines (2000)

This chapter contains sections titled: Recommendations for survey design Scope of geostatistical techniques Guidelines
AUSTRIAN TRAFFIC MANAGEMENT AND INFORMATION CENTRE (TMIC) (2006)

The new Traffic Management and Information Centre (TMIC) in Vienna-Inzersdorf is the heart of a trend-setting national traffic management and information system for the Austrian motor- and expressway network. The main functions are: Gathering of relevant traffic data from the entire ASFINAG network, processing and displaying in the Traffic Management and Information Centre and distribution via road side infrastructure and value added services. The traffic management and information system is the soft information network which ASFINAG is overlaying onto the hard road network, to provide safe, comfortable and high-performance transport routes. For the covering abstract see E134653.
Sintesis en fase solida de oligonucleotidos ciclicos (1996)

SE HA DISENADO Y PUESTO A PUNTO UN NUEVO METODO DE SINTESIS EN FASE SOLIDA DE OLIGONUCLEOTIDOS CICLICOS. EL ESQUEMA SINTETICO SE INICIA CON EL ANCLAJE A LA MATRIZ POLIMERICA DEL NUCLEOTIDO 3'-TERMINAL A TRAVES DEL ACIDO 3- CLORO-4-HIDROXIFENILACETICO, CUYO HIDROXILO FENOLICO ESTERIFICA Y PROTEGE EL FOSFATO MIENTRAS QUE EL ACIDO CARBOXILICO ESTABLECE UN ENLACE AMIDA CON EL SOPORTE SOLIDO. EL GRUPO FOSFATO SE ENCUENTRA PROTEGIDO ADEMAS CON EL GRUPO 2-CIANOETILO. PARTIENDO DE ESTA NUCLEOTIDIL-RESINA, EL ENSAMBLAJE DE LA CADENA OLIGONUCLEOTIDICA SE REALIZA POR EL METODO DEL FOSFITO TRIESTER UTILIZANDO METILFOSFORAMIDITOS Y LOS GRUPOS PROTECTORES DEL HIDROXILO 5' Y DE LAS BASES HETEROCICLICAS QUE SON HABITUALES EN SINTESIS DE OLIGONUCLEOTIDOS. LA CICLACION ENTRE EL HIDROXILO 5' Y EL FOSFATO 3'-TERMINAL DE LA CADENA LINEAL (PREVIA ELIMINACION DEL GRUPO CIANOETILO) TIENE LUGAR SOBRE EL SOPORTE POLIMERICO POR EL METODO DEL FOSFATO TRIESTER. TRAS LAS ETAPAS DE DESPROTECCION Y DESANCLAJE SE OBTIENE EL OLIGONUCLEOTIDO CICLICO.
Polymer Supported Carbon for Safe and Effective Remediation of PFAS-Contaminated Water (2019)

Powdered activated carbon (PAC) is an economical sorbent for removing micropollutants from water, but it generates hazardous dust that is flammable and a respiration hazard. Additionally, the fine particles of PAC can cake and block filters and membranes, complicating its use in continuous processes. In this study, we present a sulfur polymer support for PAC that overcomes these problems. The blend of the sulfur polymer and PAC generates low dust and it does not block filters. The utility of the sorbent is demonstrated in the remediation of water contaminated with perfluorinated alkyl substances (PFASs)—persistent micropollutants that currently threaten water safety worldwide. Fundamental discoveries of PFAS self-assembly are reported, as well as testing on field samples.
Preparation and explosive properties of azo- and azoxy-furazans (2000)

Abstract The synthesis and properties of three energetic azo- and azoxyfurazans are described. All are derived from oxidation of 3, 4-diaminofurazan (DAF) (1) and include 3,3′-diamino-4,4′-azoxyfurazan (DAAF) (2), 3,3′-diamino-4,4′-azofurazan (DAAzF) (3) and bis[1, 2, 5] oxadiazolo [3,4-c:3′,4′-g] [1, 2, 5, 6] tetrazocine (DFT) (4). The explosive performance properties of DAAF and DAAzF have been investigated.
Effects of trimethoprim-sulfamethoxazole and incubation atmosphere on isolation of group A streptococci (1983)

The effects of selective media and incubation atmosphere on the isolation of group A beta-hemolytic streptococci were evaluated. A higher percentage of group A streptococci was isolated on sheep blood agar incubated in air than in CO2 or anaerobic atmospheric conditions. Fewer non-group A beta-hemolytic streptococci were isolated on sheep blood agar incubated in air than in CO2 or anaerobically. Group A streptococcal isolation was not significantly affected by different incubation atmospheres on sheep blood agar containing trimethoprim-sulfamethoxazole, but detection time was longer than on sheep blood agar alone. No significant difference was found between isolation of group A streptococci on sheep blood agar incubated in air and that on sheep blood agar containing trimethoprim-sulfamethoxazole and incubated in 5 to 10% CO2; however, more group A streptococci were isolated on sheep blood agar in air within 24 h. Sheep blood agar incubated at 35 degrees C in air is, therefore, recommended for the isolation of group A streptococci from throat swabs.
Uremia and Host Defenses (1990)

IN the first edition of his Principles and Practice of Medicine, Sir William Osler stated that the clinical manifestations of uremia are caused by the retention of the excretory products. The nature of these poisonous ingredients is not yet known. It was formerly thought that the urea was the offending substance, and it has been found increased in the blood in uraemia.... It is more probable, however, that there are several toxic agents at work.1 Nearly a century later, Ruiz et al.2 have employed modern immunologic techniques to investigate one important aspect of the uremic syndrome — the effects . . .
One Site is Enough. Catalytic Water Oxidation by [Ru(tpy)(bpm)(OH<sub>2</sub>)]<sup>2+</sup> and [Ru(tpy)(bpz)(OH<sub>2</sub>)]<sup>2+</sup> (2008)

Water oxidation is a key reaction in natural photosynthesis and in many schemes for artificial photosynthesis. Although metal complexes capable of oxidizing water based on Ru, Mn, and Ir are known, a significant question is whether or not dimeric or higher order structures are required for water oxidation. We report here single-site catalytic water oxidation by the monomeric complexes [Ru(tpy)(bpm)(OH2)]2+ and [Ru(tpy)(bpz)(OH2)]2+ (tpy is 2,2′:6′,2′′-terpyridine; bpm is 2,2′-bipyrimidine; bpz is 2,2′-bipyrazine) by a well-defined mechanism involving RuV═O.