gebhart/patrepeval huggingface dataset:
Forensic DNA typing using a trehalose stabilized PCR reaction mixture (2013)

Perhaps one of the greatest challenges faced by the forensic DNA\nlaboratory today is that of backlog reduction. Automation is the key to reducing\nbacklog, but even with current automated methods much time is spent on liquid\nhandling. The goal of this study was to demonstrate a proof-of-concept that would\nreduce liquid handling by creating a stable, dry, and ready-to-use PCR reagent\nmixture by incorporating the sugar trehalose into the mixture. This study was\nconducted to determine whether: 1) the addition of trehalose affected amplification\nof forensically relevant STR loci, 2) freeze-drying and adverse storage conditions\naffected the reagent mixture, and 3) long term storage of the PCR reagent mixture\naffected the quality of forensic DNA profiles. The addition of trehalose to the ABI\nIdentifiler??? kit PCR master mix did not adversely affect the PCR reaction. In the\nabsence of trehalose, PCR master mix stored at -20???C and 22-25???C failed to yield\ncomplete DNA profiles (with the exception of a single frozen sample). In stark\ncontrast, complete DNA profiles were obtained for trehalose preserved lyophilized\nPCR master mix stored at -20???C and at 22-25???C. A minimum of 8 of the 16 loci\nwere profiled at 50???C, with fewer peaks found at 60???C. DNA profiles were not\nobtained from lyophilized reaction mixtures stored at 90???C. ABI Identifiler???\nmaster mix preserved with trehalose was viable for up to 6 weeks at 18-23???C and\nmay be viable for longer periods of time. After further optimization, trehalose\npreserved master mix can potentially lead to preloaded 96 or 384-well plates,\nwhich would lend them for use in automating the PCR reaction process.
A Runtime Software Visualization Environment (2002)

"As software systems become more complex, so does the task of understanding them. To modify even a simple component of a complex system, at least a rudimentary understanding of the structure and behavior of the whole system is necessary. Although currently available development tools can provide a static representation of a complex system, these utilities are severely limited and prohibitively expensive. As a result, most programmers working on large software systems today resort to classic debuggers and time-consuming plain-text searches through hundreds or thousands of source files. This proposal describes a software development environment that uses static representations of hierarchically structured source code side by side with dynamic visualizations of software systems as they run. This environment provides an intuitive, visual means of easily comprehending complex systems, and has been provided as an open-source development tool for both professionals and students of software engineering."
Interferometric measurement of dispersion of a single-mode optical fibre (1981)

The methods of Fourier transform spectroscopy are applied to the measurement of the dispersion of short lengths of a single-mode optical fibre. The fibres used were one metre or less in length.
E-VIVEGAM - sim card based vehicle speed control system (SIMCON) (2008)

The above words have a lot more meaning than they may seem to have. The so called globalised world of today pushed by the thirst for money has inexorably led to a hectic mechanical life. This craze of the people had made men forget the values of humanity and the very basic necessity for existence has been pathetically forgotten. 'Break the rules' the fashionable slogan of the age has been so ardently followed by the people.Rules seem to be existent only in paper and not in actual life. One of those many such violations is manifested in the form of fatal accidents induced by undisciplined road users. It is high time that the so called regulations which reside as mere documents serving the purpose of no one be enforced without compromise. So our idea is to regulate traffic smoothly by using a mechanism to make sure that the speed of the vehicle is not exceeded beyond the set speed limit.
Efficient commit protocols for the tree of processes model of distributed transactions (1983)

This paper describes two efficient distributed transaction commit protocols, the Presumed Abort (PA) and Presumed Commit (PC) protocols, which have been implemented in the distributed data base system R* [DSHLM82, LHMWY83]. PA and PC are extensions of the well-known two-phase (2P) commit protocol [Gray78, Lamp80, LSGGL80]. PA is optimized for read-only transactions and a class of multi-site update transactions, and PC is optimized for other classes of multi-site update transactions. The optimizations result in reduced inter-site message traffic and log writes, and, consequently, a better response time for such transactions. We derive the new protocols in a step-wise fashion by modifying the 2P protocol.
Comparison of the hemodynamic effects of midazolam and diazepam in patients with coronary occlusion. (1989)

Midazolam is gradually replacing diazepam in neuroleptanalgesia with fentanyl and sufentanil because of its greater water solubility, greater hypnotic potency, shorter half-life, lack of pharmacologically active metabolites and low incidence of thrombophlebitis. In order to substantiate midazolam as being as safe and effective as diazepam in cardiac patients with severe coronary occlusion, hemodynamic measurements were made before and 10 min after completion of intravenous injection of 0.2 mg/kg i.v. midazolam (n = 45) and 0.4 mg/kg i.v. diazepam (n = 30), the doses which are identical to those used in patients undergoing cardiac catheterization. All 75 patients were spontaneously breathing 40% O2 in air. No positional changes or stimulation of patients were allowed before and during the study. Of hemodynamic variables, systemic systolic blood pressure was significantly reduced by both midazolam and diazepam. Midazolam also caused significant reduction in systemic vascular resistance with reduction in diastolic pressure and left ventricular stroke work index. No changes in heart rate, systolic and diastolic pulmonary artery pressures, cardiac output and index, stroke volume and index, pulmonary vascular resistance, right ventricular stroke work index and rate pressure product were observed following either midazolam or diazepam. No statistically significant differences were observed in any hemodynamic variable between those patients receiving midazolam or diazepam. It is concluded that midazolam is as safe as diazepam in cardiac patients with coronary obstruction.
The OISE Modern Language Center Today (1971)

Two years ago, I described our plans for a Modern Language Center in the Ontario Institute for Studies in Education (“Language Centers Today and a New Modern Language Center at OISE”, Canadian Modern Language Review, Vol. XXV, No. 2, January 1969, p. 9-2 1). As readers will have seen from the issue of the Review which appeared last June, (Canadian Modern Language Review, Vol. XXVI, No. 4, June 1 970, p. 65), the Center is now established in its own quarters in the new building of OISE. It is perhaps, therefore, an opportune moment for making known to readers the range of activities in which the Modern Language Center is at present engaged. This can most easily be done by reproducing the content of a folder describing the scope, work and staffing of the Modern Language Center. Single or multiple copies of this folder can be obtained (free of charge) by writing or phoning Mrs. Stella Lord, Senior Secretary, Modern Language Center, at 252 Bloor Street West, Toronto 1 8 1 , Ontario, Canada, Tel. 923-664 1, Ext. 64 1, 642.
Effect of some herbicides on egg parasitism and development of Trichogramma chilonis Ishii (Trichogrammatidae: Hymenoptera). (2006)

Herbicides may affect natural enemy activity either by destroying their food and host resources or by killing them directly or by repelling them from the treated area. Laboratory study was conducted to work out the effect of six herbicides namely, pretilachlor, paraquat, sulfosulfuron, 2, 4 DEE, Sumisoya and imazosulfuron, each at three dosages, on the pupal mortality, egg parasitism and subsequent development of Trichogramma chi/on is Ishii, an egg parasitoid of lepidopteran crop pests. The herbicides caused 0 10.65% mortality of the treated pupae and all the herbicides were considered to be safe to pupal stage of the parasitoid. 2, 4 DEE caused considerable reduction to the parasitism of treated eggs by the parasitoid, whereas, others had little to moderate levels of adverse effect on egg parasitism. The herbicides had no marked adverse effect on adult longevity. None of the herbicides affected tl1e subsequent emergence of the adults from treated host eggs. Reduction of egg parasitism in some herbicides may be either due to the repellent action of these chemicals themselves or due to adjuvanls used in fommlation.
Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition (2008)

Taken together, these data demonstrate an important role for COX-2 in the regulation of angiogenesis in HIMECs via MAPKs. Moreover, curcumin inhibits microvascular endothelial cell angiogenesis through inhibition of COX-2 expression and PGE(2) production, suggesting that this natural product possesses antiangiogenic properties, which warrants further investigation as adjuvant treatment of IBD and cancer.
DEVELOPMENT OF AN ADVANCED SNOWPLOW DRIVER ASSISTANCE SYSTEM (ASP-II) (2000)

This report documents Phase Two of the development of the Advanced Snowplow (ASP), a system which includes lane position indication, lane departure warning, and a forward collision warning system. The system was implemented on a California Department of Transportation (Caltrans) snowplow and tested in the California Advanced Winter Maintenance Testbed on Interstate 80 near Donner Summit and on US 180 near Flagstaff, Arizona. This report givers a brief history of Phase One, a system overview, and also describes major subsystems and functions. It also describes the human machine interface (HMI) magnetic sensing system, and the radar-based collision warning system (CWS). Included in the report are discussion regarding improvements made based on findings from Phase One research, evaluation conclusions, and plans for future research.
Plant Drought Stress and Outbreaks of Spider Mites: A Field Test (1990)

I conducted a field experiment to clarify the relationship between drought stress of bush beans, Phaseolus vulgaris, and outbreaks of the twospotted spider mite, Tetranychus urticae, in the presence or absence of an important spider mite predator, Phytoseiulus persimilis. Spider mite populations were highest on well—watered and on severely stressed bean plants and lowest on slight—to—moderately stressed plants, indicating a nonlinear relationship. The predator exaggerated this pattern, reducing mite populations the most on moderatley stressed plants and having the least impact on mites from severely stressed plants. Number of mites per unit leaf mass (a measure of mite injury to plants) was highest on severely stressed plants, lowest on slightly stressed plants, and intermediate on well—watered plants. Bean yield was negatively influenced by drought stress, with those plants that experienced high numbers of mites per unit leaf mass appearing to be more sensitive to drought than plants with low numbers of mites. The implications of these data for understanding the causes of pest outbreaks are discussed.
E (2007)

EAEC: East Asia Economic Caucus. A consultative group proposed in the early 1990s by Malaysia which, if implemented, would consist of East Asian countries. See also ASEAN+3.
Antiplatelet therapy with glycoprotein IIb/IIIa receptor inhibitors and other novel agents. (1997)

Aspirin has stood the test of time over decades as the gold standard for relatively effective, safe, and inexpensive antiplatelet therapy. However, aspirin is only modestly effective in preventing arterial thrombosis in certain settings, and it is virtually ineffective in others (for example, preventing coronary restenosis after angioplasty). These observations have been the impetus for the development of more effective antiplatelet strategies, the rational basis of which is largely our understanding of normal platelet function. The most clinically effective platelet inhibitors yet developed produce broad inhibition of platelet function by blockade of the final common pathway of aggregation, in which fibrinogen binds to its platelet membrane receptor localized in the glycoprotein (Gp) IIb/ IIIa complex. The Gp IIb/IIIa complex is a member of the family of integrins, which are cell membrane receptors for adhesive proteins. The binding of fibrinogen to platelet Gp IIb/IIIa occurs via a specific amino acid sequence, arginine-glycine-aspartic acid. Effective antagonists of platelet Gp IIb/IIIa function have included monoclonal antibodies against Gp IIb/IIIa, peptide (peptidomimetic) antagonists of Gp IIb/IIIa, and nonpeptide (nonpeptide mimetic) antagonists of Gp IIb/IIIa. The major risk of any antiplatelet strategy is the potential for bleeding complications, since currently we do not understand the molecular distinction between protective hemostasis and pathologic thrombosis.
Upregulation of Pluripotency Markers in Adipose Tissue-Derived Stem Cells by miR-302 and Leukemia Inhibitory Factor (2014)

The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. Moreover, there is no data about the signaling molecules that regulate these markers in ADSCs. In the present study, we studied the roles of leukemia inhibitory factor (LIF) and miR-302 in this regard. Freshly isolated mouse ADSCs expressed hematopoietic, mesenchymal, and pluripotency markers. One day after plating, ADSCs expressed OCT4 and Sox2 proteins. After three passages, the expression of hematopoietic and pluripotency markers decreased, while the expression of mesenchymal stem cell markers exhibited a striking rise. Both supplementation of culture media with LIF and transfection of the ADSCs with miR-302 family upregulated the expression levels of OCT4, Nanog, and Sox2 mRNAs. These findings showed that mouse adipose tissue contains a population of cells with molecular resemblance to embryonic stem cells, and LIF and miR-302 family positively affect the expression of pluripotency markers.
Induction of Primordial Germ Cells from Pluripotent Epiblast (2002)

The formation of germ cells during embryogenesis bears the ultimate importance for the continuation of every species. It becomes evident that mechanisms governing germ cell fate specification are not well conserved across the animal kingdom. In most of the invertebrate and nonmammalian vertebrate species, certain maternally derived factors are key to the establishment of germ cell lineage. In contrast, mouse primordial germ cells (PGCs) are induced from the pluripotent epiblast cells before and during gastrulation by the extraembryonic cell-derived signals. The molecular identity for some of these signals has recently been revealed by genetic and epiblast culture experiments. Both bone morphogenetic proteins 4 (Bmp4) and 8b (Bmp8b) are expressed in the extraembryonic ectoderm and are required for PGC formation. Furthermore, BMP4 or BMP8B alone are unable to induce PGCs from cultured epiblasts, while they can in combination, indicating they signal through separate receptor complexes. In addition, Bmp4 homozygous embryos cannot be induced to form PGCs by the synergistic action of BMP4 and BMP8B, suggesting that BMP4 proteins produced by pregastrula embryos are required for epiblast cells to maintain pluripotency. Moreover, Bmp2, a close relative of Bmp4, is expressed in visceral endoderm at the time of PGC specification, and inactivation of Bmp2 results in a reduction in PGC number, revealing a novel function of visceral endoderm in PGC generation in the mouse.
Synthesis and Analgesic Activity of Some Side-Chain Modified Anpirtoline Derivatives (2000)

New derivatives of anpirtoline and deazaanpirtoline modified in the side chain have been synthesized. The series includes compounds 3 with side-chains containing piperidine or pyrrolidine rings, compounds 4 containing 8-azabicyclo[3.2.1]octane moiety, and compounds 5 having piperazine ring in their side-chains. Their receptor binding profiles (5-HT1A, 5-HT1B) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. Optimized structures (PM3-MOPAC, Alchemy 2000, Tripos Inc.) of the synthesized compounds 3-5 were compared with that of anpirtoline.
Pascal: The Language and Its Implementation (1981)

Presents a number of views of the PASCAL programming language. Combines the proceedings of a recent symposium, reprints of a number of rare PASCAL classics, '' and some intervening contributions by symposium authors.
Requirements for schwann cell migration within cns environments: A viewpoint (1993)

Schwann cells are able to migrate into the CNS and myelinate CNS axons in a number of developmental and pathological situations. Morphological studies based on normal, mutant and experimentally-lesioned tissue have indicated that Schwann cells are only able to enter the CNS when the integrity of the astrocytic glia limitans is disrupted. The significance and subtlety of the interactions between Schwann cells and astrocytes have been further explored by glial cell transplantation studies. These studies support in vitro observations on Schwann cell behaviour in highlighting the importance of extracellular matrix for both migration and myelin sheath formation. The failure of Schwann cells to intermix with astrocytes is an important aspect of glial cell biology which will have a bearing on efforts to remyelinate demyelinated axons by Schwann cell-transplantation.
A Research of Job Recommendation System Based on Collaborative Filtering (2014)

Dealing with the enormous amount of recruiting information on the Internet, a job seeker always spends hours to find useful ones. To reduce this laborious work, we design and implement a recommendation system for online job-hunting. In this paper, we contrast user-based and item-based collaborative filtering algorithm to choose a better performed one. We also take background information including students' resumes and details of recruiting information into consideration, bring weights of co-apply users (the users who had applied the candidate jobs) and weights of student used-liked jobs into the recommendation algorithm. At last, the model we proposed is verified through experiments study which is using actual data. The recommended results can achieve higher score of precision and recall, and they are more relevant with users' preferences before.
GPR40 Carboxylic Acid Receptor Family and Diabetes: A New Drug Target (2008)

Type-2 diabetes is strongly linked to visceral obesity and elevated levels of circulating free fatty acids. For years this correlation of obesity to diabetes has intrigued the minds of researchers and research in this direction has led to a possible solution to this question. Human Genome project has identified nearly 150 orphan GPCRs. The reverse pharmacology approaches have identified free fatty acids as ligands for the GPR40 family of orphan receptors. This review mainly emphasizes on the role of GPR40 carboxylic acid receptor family in the development of diabetes along with detailed coverage of each receptor of the family. GPR40 family has provided an insight into regulation of carbohydrate and lipid metabolism in vertebrates and has further provided targets for the development of therapeutic agents useful for treating or preventing disorders such as Type-2 diabetes. This review also suggests where further research and development could be beneficial.
Electric Machinery and Power System Fundamentals (2001)

1 Mechanical and Electromagnetic Fundamentals 2 Three-Phase Circuits 3 Transformers 4 AC Machinery Fundamentals 5 Synchronous Machines 6 Parallel Operation of Synchronous Generators 7 Induction Motors 8 DC Motors 9 Transmission Lines 10 Power System Representation and Equations 11 Introduction to Power-Flow Studies 12 Symmetrical Faults 13 Unsymmetrical Faults
Summary Abstract: Epitaxial growth of ZnS and ZnSe on the low index faces of GaAs using atomic layer epitaxy (1987)

First Page
Reading of electronic documents (2001)

Reading of electronic documents is becoming increasingly important as more information is disseminated electronically. We present an experiment that compares the usability of a linear, a fisheye, and an overview+detail interface for electronic documents. Using these interfaces, 20 subjects wrote essays and answered questions about scientific documents. Essays written using the overview+detail interface received higher grades, while subjects using the fisheye interface read documents faster. However, subjects used more time to answer questions with the overview+detail interface. All but one subject preferred the overview+detail interface. The most common interface in practical use, the linear interface, is found to be inferior to the fisheye and overview+detail interfaces regarding most aspects of usability. We recommend using overview+detail interfaces for electronic documents, while fisheye interfaces mainly should be considered for time-critical tasks.
Transitions: Intra-familial Inheritance (1995)

Abstract This chapter discusses the most common way that a man could gain membership of the landed elite which was by inheritance from a relative of seat, estates, status, and title. He could obtain this inheritance in three basic ways, the most straightforward being directly from his father or grandfather in his capacity as the eldest living son or grandson. This was the ideal model of inheritance according to patrilineal and primogenitural principles. Failing such direct descent, the inheritance tended to pass indirectly to the nearest male relative, priority being given to a younger brother or nephew. The principal conclusion of this chapter, however, was the extraordinary degree of family continuity. Thanks to the skillful shift from direct inheritance by heirs to indirect inheritance by relatives, families contrived to survive the demographic crisis of 1650–1740.
Vinyl Aromatic Compounds. III. Fluorinated Derivatives<sup>1</sup> (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVinyl Aromatic Compounds. III. Fluorinated Derivatives1Mary W. RenollCite this: J. Am. Chem. Soc. 1946, 68, 7, 1159–1161Publication Date (Print):July 1, 1946Publication History Published online1 May 2002Published inissue 1 July 1946https://pubs.acs.org/doi/10.1021/ja01211a008https://doi.org/10.1021/ja01211a008research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts