gebhart/patrepeval huggingface dataset:
The Clinical and Morphologic Features of Nonepidermolytic Ichthyosis in the Golden Retriever (2008)

A scaling disorder specific to Golden Retriever dogs has been recognized by both dermatologists and pathologists, but to date has not been well characterized. At the University of Pennsylvania's Laboratory of Toxicology and Pathology, 46 cases of ichthyosis were diagnosed histologically in Golden Retriever dogs from January 2004 to January 2007. A total of 22 dogs had skin lesions documented at younger than 1 year of age; 3 dogs between 1 and 2 years of age; 13 dogs developed lesions at older than 2 years; and the time of onset was unknown for 8 dogs. A total of 25 dogs were female, and 21 were male. All dogs had strikingly similar histopathologic changes that consisted of mild to moderate laminar orthokeratotic hyperkeratosis with an absence of epidermal hyperplasia and dermal inflammation. Ultrastructural analysis using a ruthenium tetroxide fixation method was performed on punch biopsy samples from 5 dogs and compared with 2 control dogs (1 clinically and histologically normal sibling of an affected dog and 1 Cairn Terrier). All affected dogs had retained and convoluted membranes with crystalline structures in the stratum corneum. Scattered keratinocytes in the granular cell layer had prominent, clear, membrane-bound, cytoplasmic vacuoles. Pedigree analysis of 14 dogs was compatible with autosomal recessive inheritance, but incomplete dominance could not be ruled out. This unique hyperkeratotic/scaling disorder in Golden Retrievers has distinctive clinical, histologic, and ultrastructural features, which are consistent with a primary cornification defect.
Integration of value-added audio playback capacity into computer network (2002)

Multimedia PCs with audio and video capabilities are used as information kiosks to provide entertainment multimedia information services to users and visitors on the NTU campus. The paper describes the development of a prototype multimedia information kiosk that incorporates the capabilities of recording an playback of FM radio programmes in a network environment. The system includes a dedicated server program that is capable of recording requested radio programmes. Subsequently, all network multimedia PCs will be able to access these recorded sound files via a user friendly interface which allows them to select and playback any of the pre-recorded FM radio programmes. The server makes use of the existing file services in the network for transmitting audio information. The file services allow a client PC residing anywhere within the network to access the contents of a particular file in the server. To playback the sound files, the MCI (multimedia control interface) services provided by Microsoft Windows 3.1 are also used extensively. With this interface, several sound controls such as play, pause, forward, rewind as well as recordings are made available.
Apoptosis-related gene expression in glioblastoma (LN-18) and medulloblastoma (Daoy) cell lines (2013)

The expression of apoptosis genes in a commercial pre-designed low-density array from Applied Biosystems was evaluated in two human brain cancer cell models, LN-18 and Daoy (HTB-186™) in comparison to the reference human primary endothelial cells under basic conditions. Analysis of the gene expression in the cancer cell lines compared to the normal control revealed features reflecting anti-apoptotic and inflammatory characteristics of the former. There was an overall downregulation of apoptosis-stimulating genes in both cancer cell lines, along with an upregulation of certain apoptosis inhibitors. A number of genes demonstrated statistically significant changes in their expressions, including BAX (BCL2-associated X protein); the CARD4/NLR family, CARD domain containing 4; CASP10 (caspase 10, apoptosis-related cysteine peptidase); DAP1 (death-associated protein kinase 1), and BIRC5 (baculoviral IAP repeat-containing 5). Anti-apoptotic potential in both cell lines was demonstrated by changes in the Bax:Bcl-2 ratio and downregulation of the APAF1 gene in LN18 cells. There was also significant downregulation of extrinsic signals and the TNF/FADD/inflammatory cascade, and upregulation of caspase inhibitors (IAPs). These results provided a novel molecular characterization of important human cancer cell lines, which might provide a useful research tool for investigating the experimental model of the CNS cell.
Agile Knowledge Management (2009)

This article is based on the assumption that Knowledge Management (KM) is a vital part of any project. Based on this working assumption, the purpose of this article is to introduce the term Agile Knowledge Management (AKM) by illustrating how the Agile Software Development (ASD) approach is suitable for the introduction of KM processes. The ASD approach emerged over the past decade in response to the unique problems that characterize software development processes (Highsmith, 2002). In general, ASD emphasizes customer needs, communication among team members, short releases and heavy testing throughout the entire development process. These ideas are implemented quite variedly by the different ASD development methods. Knowledge Management (KM) and Agile Software Development (ASD) are two organizational processes that face common barriers when introduced and applied. This article suggests that because the field of KM presents a less disciplined approach compared with ASD, it is logical that KM practitioners should learn how ASD has coped with very similar barriers. We further illustrate how it is but natural to emphasize the concept of Agile Knowledge Management (AKM) in order to improve KM processes, because ASD already encompasses the organizational and cultural infrastructure needed for KM. The pairing of KM and ASD is not new; a connection between the two concepts has been acknowledged by various researchers. For related discussions, see, for example, Dove (1999) and Holz, Melnik and Schaaf (2003). This connection, however, is not surprising because both disciplines deal with organizational culture and change management. In what follows, we further highlight the connection between the two fields. First, we show that the two processes, KM and ASD, face the same barriers when introduced into an organization. We also include some suggestions for coping with such barriers. Second, we highlight the way in which KM is already embedded into ASD processes. Thus, in order to improve KM in such processes, it should be made more explicit. Accordingly, we introduce an agile KM manifesto.
Nucleic acids and nuclear magnetic resonance (1988)

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Integrating the Healthcare Enterprise: A Primer (2002)

Recently, one of my friends, a computer wizard, paid me a visit. As we were talking, I mentioned that I had recently installed a picture archiving and communication system and a radiology information system. I told him how happy I was with the system and showed him a compact disk (CD) from it. To my surprise, he threw it into my microwave oven and turned it on. Instantly I got very upset, because the System had become precious to me, but he said, "Do not worry, it is unharmed." After a few minutes, he took the CD out, gave it to me and said, "Take a close look at it." To my surprise, the CD was quite cold to hold and it seemed to be heavier than before. At first, I could not see anything, but on the inner edge of the central hole, I saw an inscription, an inscription finer than anything I had ever seen before. The inscription shone piercingly bright, and yet remote, as if out of a great depth: 12413AEB2ED4FA5E6F7D78E78BEDE8209450920F923A40Eel0E50CC98D444AA08E324. "I cannot understand the fiery letters," I said in a timid voice. "No, but I can," he said. "The letters are Hex, of an ancient mode, but the language is that of DICOM, which I shall not utter here. But in common English, this is what it says: Two integration profiles to schedule work flow. Five for radiology with room to grow. One for the bacon to bring it home. One for HIPAA all alone. And one for results for those who would know. One technical framework in which to find them. One technical framework to guide them. One technical framework to bring them all. And in the Connect-a-thon bind them. In the Land of Lincoln where no shadows are. We continue the saga of the fellowship of the IHE: clinicians, radiologists, informaticians, administrators, technologists, imaging system vendors, and non-imaging system vendors, as they begin their year 4 transactions.
Engineering Rock Mass Classifications: A Complete Manual for Engineers and Geologists in Mining, Civil, and Petroleum Engineering (1989)

Role of Rock Mass Classifications in Site Characterization and Engineering Design. Early Rock Mass Classifications. Geomechanics Classification (Rock Mass Rating System). Q--System. Other Classifications. Applications in Tunneling. Applications in Mining. Other Applications. Case Histories Data Base. Appendix. Bibliography. Index.
Protection performance and analysis for faults in generating units and transformers (2012)

Understanding the criticality of generator, excitation system and transformer for the active existence of power plant it is utmost necessary to maintain them under protective environment.The need to analyze the possible causes and required protection is diagnosed during the design stage itself.The generator main circuit connecting to generator transformer, UAT and Excitation Transformers is through Isolated Phase Bus-ducts. Possibility of occurrence of ground or phase faults would be seldom.The priority of protection relay scheme and setting is to safely isolate the fault as fast as possible and at the same time maintain stability in grid and generator at the power plant.Protection relay shall be coordinated with generator excitation control system such as Automatic Voltage Regulator (AVR), Thyristors etc.Case study has been prepared based on the past experience of project feedbacks.
A Technique for Dust Measurement (1989)

The presence of dust in either pesticide formulation ingredients or the finished product is a nuisance at best. Dust in the pesticide industry is commonly measured as minus 60 mesh (250 micrometers) material. Dust itself is much smaller airborne particulate matter. A device was constructed to measure airborne particles by weight and light absorption. A sample is introduced through a port into a 0.0566 m3 space. Dust generated during the fall is measured optically and gravimetrically. Absorbance is determined with a tungsten light source, a cadmium sulfide detector and a 0.305 m path length. Dust weight is determined by evacuation of the air above the sample and collection on filter paper. Instrument performance was determined with three types of absorbent minerals, a hormite, a montmorillonite and a diatomite. Light absorption and dust weight were linear with the amount of material introduced. Though materials were slightly different colors, a linear correlation was observed in dust weight vs. absorption plots. Particles in the dust ranged from 2 to over 200 microns, averages ranging from 20 to 65 microns.
Infertility in heifers inoculated with modified-live bovine herpesvirus-1 vaccinal strains against infectious bovine rhinotracheitis on postbreeding day 14. (1989)

Heifers were inoculated IV with 1 of 4 modified-live bovine herpesvirus-1 vaccinal strains against infectious bovine rhinotracheitis (2 heifers/strain) on postbreeding day (PBD) 14. The effect of infection on fertility was monitored by plasma progesterone assay at 1- to 3-day intervals from the time of virus exposure until PBD 60. Infertility was detected in 4 of 8 inoculated heifers. In 2 heifers, progesterone concentrations decreased to values indicative of estrus within 10 days after inoculation (PBD 24). The 2 other heifers had evidence of embryonic death on PBD 40 and 42. Two control heifers inoculated with culture medium from noninfected cells maintained their pregnancies.
Microparticles in cardiovascular diseases (2003)

Microparticles are membrane vesicles released from many different cell types. There are two mechanisms that can result in their formation, cell activation and apoptosis. In these two mechanisms, different pathways are involved in microparticle generation. Microparticle generation seems to be a well regulated process. Microparticles vary in size, phospholipid and protein composition. They have a potent pro-inflammatory effect, promote coagulation and affect vascular function. Since these processes are all involved in the pathogenesis of cardiovascular disease and circulating microparticle numbers are altered in many cardiovascular diseases, a role for microparticles in the pathogenesis of cardiovascular diseases is likely. Although hard evidence for a role of microparticles in cardiovascular diseases at present is still only limited, new evidence is accumulating rapidly to support this theory. Elucidation of the microparticle composition and the mechanisms involved in exertion of their effects will supply this evidence and enable us to develop additional intervention strategies for prevention and treatment of cardiovascular diseases.
Crossed-Coil Power-Factor Meters (1944)

The fundamental relations governing operation of the crossed-coil type of power-factor meter are derived for the particular measurement applications on single-phase, three-wire two-phase, three-wire three-phase, and four-wire three-phase circuits. Emphasis is placed on the usefulness of a graph of either the equilibrium equation or the torque relation in determining the scale distribution.
Effect of an externally applied electric field on excitation propagation in the cardiac muscle (1994)

Classical theory of potential distribution in cardiac muscle (cable theory) postulates that all effects of electric field (internally or externally applied) should decay exponentially with a space constant of the order of the tissue space constant ( approximately 1 mm). Classical theory does not take into account the cellular structure of the heart. Here, we formulate a mathematical model of excitation propagation taking into account cellular gap junctions. Investigation of the model has shown that the classical description is correct on the macroscopic scale only. At microscopic scale, electric field is modulated with a spatial period equal to the cell size (Plonsey and Barr), with the zero average. A very important new feature found here is that this effect of electric field does not decay at arbitrary big distances from the electrode. It opens the new way to control the excitation propagation in the cardiac muscle. In particular, we show that electric field can modify the velocity of propagation of an impulse in cardiac tissue at arbitrary big distances from electrode. In 2-dimensions, it can make rotating waves drift. To test these predictions, experiments with cardiac preparations are proposed.
Nutrient Composition and Physicochemical Properties of Korean Taro Flours According to Cultivars (2010)

Fibrin glue derived from pooled human blood is an effective sealant for high-porosity vascular grafts and a valuable topical hemostatic agent in heparinized patients. Use of this agent in the United States is prohibited because of potential transmission of hepatitis B, acquired immunodeficiency syndrome, and other serologically transmitted illnesses. We have developed a cryoprecipitation technique that allows preparation of fibrin glue from single-donor fresh frozen plasma. Use of this agent presumably entails no greater risk of disease transmission than intravenous administration of single-unit fresh frozen plasma. This report describes our early clinical experience with this material. Fibrin glue was used as a sealant for porous woven Dacron tubular prostheses and cardiovascular patches in 19 patients. The fibrin glue sealant has also been employed to control bleeding from needle holes and small anastomotic tears in 22 patients. No patient in this series had a bleeding complication from a suture line or graft treated with fibrin glue. This experience indicates that like fibrin glue from pooled blood, fibrin glue from single-donor plasma is effective as a graft sealant and topical hemostatic agent. Preparation of fibrin glue from single-donor plasma is simple and economical, and may provide cardiothoracic surgeons in the United States with a widely available, valuable hemostatic adjunct.
Flavonoids Suppress Androgen-Independent Human Prostate Tumor Proliferation (2000)

The present studies compared the effects of selected bioflavonoids on the proliferation of androgen-independent human prostatic tumor cells (PC-3). Complete growth retardation was observed in PC-3 cells treated with 100 microM quercetin, kaempferol, and luteolin, while isomolar genistein, apigenin, and myricetin suppressed PC-3 proliferation by 73%, 70%, and 59%, respectively (p < 0.05). Naringenin and rutin were not as effective and inhibited growth by < 25%. Exposure to increasing concentrations of quercetin and kaempferol led to a dose-dependent decrease in proliferation. Refeeding kaempferol-treated cells (50 microM) complete medium without the flavonoid resulted in a return toward control growth rates. Similar growth recovery was not observed in quercetin-treated cells. The antiproliferative response of PC-3 cells to quercetin and kaempferol was additive when supplemented to the medium at 25 microM. A block in G2-to-M phase progression was observed after the addition of 25 microM kaempferol. When quercetin reached 100 microM, an increase in the proportion of cells in the S phase became apparent within 24 hours. Apoptosis was not evident, even when concentrations of quercetin or kaempferol were raised to 100 microM. The present studies suggest that alterations in cell cycle progression contribute significantly to the antiproliferative effects of quercetin and kaempferol in PC-3 cells.
Visualization of the Distribution of Autophosphorylated Calcium/Calmodulin-Dependent Protein Kinase II after Tetanic Stimulation in the CA1 Area of the Hippocampus (1997)

Autophosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) at threonine-286 produces Ca2+-independent kinase activity and has been proposed to be involved in induction of long-term potentiation by tetanic stimulation in the hippocampus. We have used an immunocytochemical method to visualize and quantify the pattern of autophosphorylation of CaMKII in hippocampal slices after tetanization of the Schaffer collateral pathway. Thirty minutes after tetanic stimulation, autophosphorylated CaM kinase II (P-CaMKII) is significantly increased in area CA1 both in apical dendrites and in pyramidal cell somas. In apical dendrites, this increase is accompanied by an equally significant increase in staining for nonphosphorylated CaM kinase II. Thus, the increase in P-CaMKII appears to be secondary to an increase in the total amount of CaMKII. In neuronal somas, however, the increase in P-CaMKII is not accompanied by an increase in the total amount of CaMKII. We suggest that tetanic stimulation of the Schaffer collateral pathway may induce new synthesis of CaMKII molecules in the apical dendrites, which contain mRNA encoding its alpha-subunit. In neuronal somas, however, tetanic stimulation appears to result in long-lasting increases in P-CaMKII independent of an increase in the total amount of CaMKII. Our findings are consistent with a role for autophosphorylation of CaMKII in the induction and/or maintenance of long-term potentiation, but they indicate that the effects of tetanus on the kinase and its activity are not confined to synapses and may involve induction of new synthesis of kinase in dendrites as well as increases in the level of autophosphorylated kinase.
Resource Management for Device-to-Device Underlay Communication (2013)

Device-to-Device (D2D) communication is a technology component for LTE-A. The existing researches allow D2D as an underlay to the cellular network to increase the spectral efficiency. In this book, D2D communication underlaying cellular networks is studied. Some physical-layer techniques and cross-layer optimization methods on resource management and interference avoidance are proposed and discussed. WINNER II channel models is applied to be the signal and interference model and simulation results show that the performance of D2D link is closely related to the distance between D2D transmitter and receiver and that between interference source and the receiver. Besides, by power control, D2D SINR degrades, which will naturally contribute to low interference to cellular communication. A simple mode selection method of D2D communication is introduced. Based on path-loss (PL) mode selection criterion, D2D gives better performance than traditional cellular system. When D2D pair is farther away from the BS, a better results can be obtained. Game theory, which offers a wide variety of analytical tools to study the complex interactions of players and predict their choices, can be used for power and radio resource management in D2D communication. A reverse iterative combinatorial auction is formulated as a mechanism to allocate the spectrum resources for D2D communications with multiple user pairs sharing the same channel. In addition, a game theoretic approach is developed to implement joint scheduling, power control and channel allocation for D2D communication. Finally, joint power and spectrum resource allocation method is studied under consideration of battery lifetime, which is an important application of D2D communication on increasing user's energy efficiency. The simulation results show that all these methods have beneficial effects on improving the system performance.
Mixed gas separation technology using inorganic membranes (2000)

This article highlights the design and development of inorganic membranes for separating gas pairs, such as helium and carbon dioxide. It focuses mainly on work that is being carried out at the Inorganic Membrane Technology Laboratory, which will lead to these membranes being commercially applied to hydrogen and hydrocarbons.
Mapping the path of the nascent peptide chain through the 23S in the 50S ribosomal subunit (1995)

Peptides of different lengths encoded by suitable mRNA fragments were biosynthesized in situ on Escherichia coli ribosomes. The peptides carried a diazirine derivative bound to their N-terminal methionine residue, which was photoactivated whilst the peptides were still attached to the ribosome. Subsequently, the sites of photo-cross-linking to 23S RNA were analyzed by our standard procedures. The N-termini of peptides of increasing length became progressively cross-linked to nucleotide 750 (peptides of 6, 9 or 13-15 amino acids), to nucleotide 1614 and concomitantly to a second site between nucleotides 1305 and 1350 (a peptide of 25-26 amino acids), and to nucleotide 91 (a peptide of 29-33 amino acids). Previously we had shown that peptides of 1 or 2 amino acids were cross-linked to nucleotides 2062, 2506 and 2585 within the peptidyl transferase ring, whereas tri-and tetrapeptides were additionally cross-linked to nucleotides 2609 and 1781. Taken together, the data demonstrate that the path of the nascent peptide chain moves from the peptidyl transferase ring in domain V of the 23S RNA to domain IV, then to domain II, then to domain III, and finally to domain I. These cross-linking results are correlated with other types of topographical data relating to the 50S subunit.