gebhart/patrepeval huggingface dataset:
Abstract 518: Immunogenicity of cancer/testis antigen <i>XAGE-1d</i> in patients with non-small cell lung cancer (NSCLC) (2012)

Abstract BACKGROUND: Cancer/testis (CT) antigens expresses in various cancers and normal testis. Because of no expression of HLA class-I antigen in normal testis, CT antigens are promising molecular target for specific cancer immunotherapy. XAGE-1 gene has been identified as a CT-like antigen, and XAGE-1 gene has four alternative splice variants: XAGE-1a, XAGE-1b, XAGE-1c, and XAGE-1d. We previously reported that the transcript of XAGE-1a and XAGE-1b coded the same protein (GAGED2, isoform a, 81 amino acids) and the transcript of XAGE-1d coded another protein (GAGED2, isoform b, 69 amino acids). The first half of XAGE-1b and 1d protein (1-32 amino acids) is same sequence. On the other hand, XAGE-1c transcript codes some peptides but not a protein. Previously, immunogenic analyses of XAGE-1b have been performed because of its dominant expression, however, few analysis of XAGE-1d was performed. In this study, we investigated the immunogenicity of XAGE-1d in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Tumor tissue samples for extracting mRNA were obtained from NSCLC patients treated surgical resection at Nagasaki University Hospital during the period from 2005 to 2010. Sera and PBMCs were obtained from NSCLC patients who visited Kawasaki Medical School Hospital during the period from 2005 to 2010. Splising variants of XAGE-1 gene were analyzed by quantitative real-time PCR with specific TaqMan probe-primer sets. Antibody responses to XAGE-1d were analyzed by ELISA using synthesized XAGE-1b protein. In antibody-positive patients, CD4+ T-cell responses against XAGE-1d were examined by IFN-γ ELISA. Epitope-peptides recognized by XAGE-1d specific T-cells were determined by ELISA using XAGE-1d-overlapping peptides (OLPs). RESULTS: In quantitative real-time PCR, expression of XAGE-1d mRNA was observed in 16/38 specimens (42.1%) that were also positive with XAGE-1b mRNA. The correlation coefficiency of the expression was 0.8047. Protein expression of XAGE-1d was observed in cytoplasm, being different from that of XAGE-1b in the nucleus in lung cancer cell lines by immunohistochemical staining. Antibody against XAGE-1d was detected in lung cancer patients who were also positive with XAGE-1b antibody. By a limiting dilution, a CD4+ T-cell clone was obtained from PBMCs in a seropositive patient. HLA class II restricted recognition of XAGE-1d was confirmed using various allogeneic EBV-B cells as APC. 14-mer minimal epitope peptide was determined. CONCLUSION: The findings indicate that XAGE-1d co-expresses with XAGE-1b and is immunogenic in NSCLC patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 518. doi:1538-7445.AM2012-518
Experimental Investigation of Local Efficiency Variation in Fibrous Filters (2001)

Classical filtration models consider filter media as homogeneous and use an arbitrary inhomogeneity factor to account for the differences between theory and experiments. The variations in media-packing density have been experimentally observed and seen to be significant. There is minimal experimental information on the effect of these variations on filter performance. In this paper, local efficiency variations in commercial fibrous filters have been obtained for varying operating conditions. A filter scanner was developed to measure local filter efficiencies, and the features of the scanner are described in detail. The variations in local efficiencies are seen to have a Gaussian distribution, and the operating conditions and media behavior influence the variability in the local efficiency data. Theoretical modeling can be used to obtain two-dimensional packing density distribution data from the local efficiency measurements.
A novel shoe scanner using an open-access quadrupole resonance and metal sensor (2007)

Airport security and efficiency are both compromised by the process of requiring passengers to remove their shoe. A novel shoe scanner developed at the GE Security San Diego Center of Excellence uses both Quadrupole Resonance (QR) and configuration-sensitive metal detection to identify threats hidden in shoes. The shoe scanner was developed with an open-access chassis and scanning chamber that allows passengers to stand in the system in a natural position during the scanning process. More traditional magnetic resonance systems are closed or partially closed and cannot be used for screening personnel because the scanning chambers confine the object in question. The shoe scanner's novelty lies in a particular chassis geometry that allows both QR and metal screening. The resulting scanning system achieves the same level of performance as a more confining system. The shoe scanner is small enough to allow integration with other sensors such as the GE Itemizer FX<sup>TM</sup> trace detection system. In fact, the first application of the novel shoe scanner is expected to be as a component in a multi-sensor verification and security system known as the Secure Registered Traveler (SRT) Kiosk. The SRT kiosk is designed to be used as part of the TSA's Registered Traveler Program.
Inside Cover: Hydrogen‐Bonding Induced Alternate Stacking of Donor (D) and Acceptor (A) Chromophores and their Supramolecular Switching to Segregated States (Chem. Eur. J. 32/2012) (2012)

Bis-amide-functionalized donor (D) and acceptor (A) chromophores with comparable distances between the two amide groups form alternate D–A stacking in the moderately nonpolar solvent tetrachloroethylene (TCE) to produce either a fibrillar gel or spherical reverse vesicles depending on linker length. In the highly nonpolar medium methylcyclohexane (MCH) alternately stacked D and A chromophores switch over to a segregated 1D assembly of individual building blocks. For more details, see the Full Paper by D. Koley, S. Ghosh et al. on page 9849 ff.
Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis (1997)

The aim of this study was to investigate whether serum levels of cartilage and bone macromolecules can be used to monitor tissue destruction in experimental arthritis in rats. Serum levels of cartilage oligomeric matrix protein (COMP) and bone sialoprotein (BSP) were measured by novel immunoassays in the chronic and destructive arthritis induced in DA rats after immunization with autologous rat native collagen type II in Freund's incomplete adjuvant. Increased serum levels of COMP and BSP were seen on day 21 after immunization, and even higher levels were observed on day 28 at termination of the experiment, paralleling increases in the clinical joint score and histopathological signs of cartilage and bone erosions. Serum analyses of these markers may be a useful non-invasive way of monitoring tissue involvement in experimental arthritis and possibly the effects of therapeutic interventions aimed at retarding tissue destruction.
Domain Wall Engineering in Lead-free Piezoelectric Materials (2008)

Lead-free ferroelectrics have become highly attractive materials from the viewpoint of a solution to environmental problems. However, as compared with Pb(Zr,Ti)0 3 (PZT) ceramics, their ferroelectric related properties were poor, and it is difficult to replace the PZT ceramics. To achieve much higher piezoelectric properties than those of PZT ceramics, the domain average engineering i.e., engineered domain configuration, is an important technique, and should be applied to lead-free ferroelectric materials. Barium titanate (BaTi0 3 ) crystal is typical lead-free ferroelectrics and there have been a number of reports on its domain average engineering. Recently, for the tetragonal BaTi0 3 crystals with the engineered domain configurations, it was found that the piezoelectric properties were significantly improved with increasing domain wall densities. This result suggests a possibility that the domain walls in the engineered domain configuration could contribute to the piezoelectric properties. Thus, to explain the domain wall contribution to the piezoelectric properties, the piezoelectric properties of the BaTi0 3 crystals were investigated as a function of domain size. Moreover, this concept was applied to grain oriented BaTi03 ceramics, and finally the lead-free piezoelectrics with d 33 of 800 pC/N were prepared by domain wall engineering.
Four New Flavonol Glycosides from the Leaves of Brugmansia suaveolens (2014)

Four new flavonol glycosides were isolated from the leaves of Brugmansia suaveolens: kaempferol 3-O-β-D-glucopyranosyl-(1'''→2'')-O-α-L-arabinopyranoside (1), kaempferol 3-O-β-D-glucopyranosyl-(1'''→2'')-O-α-L-arabinopyranoside-7-O-į-D-gluco-pyranoside (2), kaempferol 3-O-β-D-[6'''-O-(E-caffeoyl)]-glucopyranosyl-(1'''→2'')-O-α-l-arabinopyranoside-7-O-β-D-glucopyranoside (3), and kaempferol 3-O-β-D-[2'''-O-(E-caffeoyl)]-glucopyranosyl-(1'''→2'')-O-α-l-arabinopyranoside-7-O-β-D-glucopyranoside (4). The structure elucidation was performed by MS, 1D and 2D NMR analyses.
Update on Porcelain Enamel Powder and a Look Ahead—A Panel Discussion (2008)

The present status in the use of porcelain enamel powder is reported. Currently available materials and systems are described. Those expected to be offered in the near future are explained.
Nonepitaxial Thin-Film InP for Scalable and Efficient Photocathodes (2015)

To date, some of the highest performance photocathodes of a photoelectrochemical (PEC) cell have been shown with single-crystalline p-type InP wafers, exhibiting half-cell solar-to-hydrogen conversion efficiencies of over 14%. However, the high cost of single-crystalline InP wafers may present a challenge for future large-scale industrial deployment. Analogous to solar cells, a thin-film approach could address the cost challenges by utilizing the benefits of the InP material while decreasing the use of expensive materials and processes. Here, we demonstrate this approach, using the newly developed thin-film vapor-liquid-solid (TF-VLS) nonepitaxial growth method combined with an atomic-layer deposition protection process to create thin-film InP photocathodes with large grain size and high performance, in the first reported solar device configuration generated by materials grown with this technique. Current-voltage measurements show a photocurrent (29.4 mA/cm(2)) and onset potential (630 mV) approaching single-crystalline wafers and an overall power conversion efficiency of 11.6%, making TF-VLS InP a promising photocathode for scalable and efficient solar hydrogen generation.
<i>Gli3</i>‐deficient mice exhibit cleft palate associated with abnormal tongue development (2008)

Palatogenesis depends on appropriate growth, elevation, and fusion of the palatal shelves and aberration in these processes can lead to palatal clefting. We observed a high incidence of palate clefting in mice deficient in Gli3, known for its role as a repressor in the absence of Shh signaling. In contrast with several current mouse models of cleft palate, Meckel's cartilage extension, cranial neural crest migration, palatal shelf proliferation, apoptosis, and key signaling components mediated by Shh, Bmp, Fgf, and Tgfbeta, appeared unaffected in Gli3-/- mice. Palatal clefting in Gli3-/- mice was consistently associated with tongue abnormalities such as failure to flatten and improper positioning, implicating a critical role of Gli3 and normal tongue morphogenesis for timely palatal shelf elevation and joining. Furthermore, Gli3-/- palatal shelves grown in roller cultures without tongue can fuse suggesting that the abnormal tongue is likely an impediment for palatal shelf joining in Gli3-/- mutants.
The Modified Distal Horizontal Metatarsal Osteotomy for Correction of Bunionette Deformity (2005)

The modified distal horizontal metatarsal osteotomy is a stable and reliable method for correction of bunionette. Unsatisfactory results in our patients were related to prominent hardware.
Novel compatibilized nylon-based ternary blends with polypropylene and poly(lactic acid): morphology evolution and rheological behaviour (2018)

In this paper, the interaction between nylon 6 (PA6), polypropylene (PP) and poly(lactic acid) (PLA) is reported. To improve the compatibility between these immiscible polymers, a reactive compatibilization approach was used through extrusion with maleic anhydride grafted polypropylene (PP-<i>g</i>-MA). To further improve the compatibility of the phases, PLA was selected as a semi-polar polymer and a low molecular weight was used to assure a good droplet dispersion. All the blends were twin-screw extruded in the melt at different compositions. The morphologies of binary and ternary blends were investigated using microscopic techniques by means of scanning electron microscopy (SEM) and atomic force microscopy (AFM). The PP-<i>g</i>-MA grafting process was observed to have a dramatic effect on the compatibility of both the binary and ternary blends and while a drastic reduction of the PP dispersed phases particle size was observed, the affinity between PLA and PP was also highlighted. The surface tension of the homopolymers and the interfacial tension of the pairs of polymers were measured to characterize the interaction at their interfaces. The interaction of PA6/PLA appeared preferable to PLA/PP, explaining the thinner dispersion obtained for PLA phase. The morphologies observed were compared to the predictions of spreading coefficient and minimum free energy models. While both models predicted the encapsulation of PP by the PLA phase, disagreeing with the morphological results, the rheological measurement gave an explanation for this phase separation. Using rheology measurements, the interaction between the phases was further investigated and the viscosity ratios were measured for the different pairs of polymers, stressing the high interaction between PA6 and PLA with and without compatibilizer. The droplet size of the dispersed phases appeared to substantially influence the chain relaxations in the melt.
An application of PSIM simulation software for rapid prototyping of DSP based power electronics control systems (2004)

The paper presents power electronics research opportunities provided by PSIM simulation software and high performance floating point DSP controller. Advantages of PSIM's C/C++ modeling capabilities are shown by modeling of DSP controller runtime environment (RTE). Thanks to this feature source code of control algorithm targeted for the DSP can be embedded in power electronics circuit simulation. Therefore, more detailed system description can be built As a proof of this idea, simulation as well as experimental results of sensorless active rectifier control are provided.
Discovery of a Sodium-Ordered Form of Na<sub>3</sub>V<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub> below Ambient Temperature (2015)

The crystal structure of the NASICON Na3V2(PO4)3 phase (NVP) has been investigated as a function of temperature. Combining laboratory and synchrotron X-ray powder diffraction with single crystal X-ray diffraction, we demonstrate the presence of four polymorphs of NVP from 30 to 225 °C. While the high temperature γ-NVP crystallizes in the classical rhombohedral cell (S.G. R3̅c, a = 8.73382(4) Å, c = 21.91438(17) Å), the low temperature α-NVP undergoes a monoclinic distortion (S.G. C2/c, a = 15.1244(6) Å, b = 8.7287(3) Å, c = 21.6143(8) Å, β = 90.163(2)°) together with an ordering of the Na atoms. In the middle temperature range, two incommensurate modulated structures (β- and β′-NVP) are also reported for the first time.
Sleep induced by stimulation in the human pedunculopontine nucleus area (2009)

The pedunculopontine nucleus is part of the reticular ascending arousal system and is involved in locomotion and sleep. Two patients with Parkinson disease received electrodes that stimulated the pedunculopontine nucleus area to alleviate their severe gait impairment. Instead, we found that low-frequency stimulation of the pedunculopontine nucleus area increased alertness, whereas high-frequency stimulation induced non-rapid eye movement sleep. In addition, the sudden withdrawal of the low-frequency stimulation was consistently followed by rapid eye movement sleep episodes in 1 patient. These data have the potential to benefit patients who suffer from sleep disorders.
Disciplinas competencias y la Universidad (2014)

Este capitulo recoge un importante analisis sobre la nueva relacion entre conocimiento y sociedad, mostrando la evolucion de las disciplinas basicas y profesionales originadas en el siglo XIX y principios del XX. Partiendo de ello, se aborda la disputa entre el curriculo basado en el «conocimiento disciplinar» y el basado en las «habilidades y competencias relevantes», haciendo hincapie en la importancia de trascender este enfrentamiento para acercarse a lo que una sociedad democratica necesita de la universidad, pero sin que por ello las disciplinas pierdan su identidad.
Retrospective Analysis of Structure–Toxicity Relationships of Drugs (2012)

This chapter contains sections titled: Abbreviations Introduction Irreversible Secondary Pharmacology Primary Pharmacology and Irreversible Secondary Pharmacology Primary or Secondary Pharmacology and Reactive Metabolites: the Possibility for False Structure–Toxicity Relationships Multifactorial Mechanisms as Causes of Toxicity Clear Correlation between Protein Target and Reactive Metabolites Conclusion – Validation of Reactive Metabolites as Causes of Toxicity References
Characterizing variation in Northwest Atlantic fish-stock abundance (2012)

Abstract Rothschild, B. J., and Jiao, Y. 2012. Characterizing variation in Northwest Atlantic fish-stock abundance. – ICES Journal of Marine Science, 69: 913–922. Catch-per-tow indices obtained by research vessels for the years 1963–2009 from NAFO statistical areas 4W, 4X, 5Y, and 5Z were studied to determine how fish “apparent abundance” in the decade 2000–2009 differed from the long-term time-series. Cluster analysis of normalized catch-per-tow data indicated that the abundance and species composition of stocks in each statistical area changed dramatically over the 50-year period. There were decreases in thorny skate, ocean pout, cusk, witch flounder, and monkfish and increases in herring, haddock, northern shrimp, and spiny dogfish. Cluster analysis suggested that these decreases and increases were not gradual, but abrupt, and that these abrupt decreases and increases were concentrated in the decade of the 1980s. Observations of abrupt change were supported by regression-tree analysis of individual stocks. Examination of the interrelationship among abundance indices from different stocks by Bonferroni-adjusted correlation coefficients showed that the abundance trajectories of most stocks were uncorrelated. It appears that the set of population transitions during the decade of the 1980s was a dominant event in the statistical time-series.
Highly Effective Fluorescent and Colorimetric Sensors for Pyrophosphate over H<sub>2</sub>PO<sub>4</sub><sup>-</sup> in 100% Aqueous Solution (2005)

[Structure: see text]. This study demonstrated that Zinpyr-1*Zn2+ acts as a fluorescent and colorimetric sensor for pyrophosphate at pH 7.4. In addition, Zinpyr-1*Cu2+ and DIARB-1*Cu2+ complexes were found to act as selective fluorescent sensors for pyrophosphate. Furthermore, the chemosensors Zinpyr-1*Zn2+ and Zinpyr-1*Cu2+ show highly selective and ratiometric fluorescence changes for pyrophosphate compared with H2PO4-.
Prediction modeling of physiological responses and human performance in the heat with application to space operations (1994)

This institute has developed a comprehensive USARIEM heat strain model for predicting physiological responses and soldier performance in the heat which has been programmed for use by hand-held calculators, personal computers, and incorporated into the development of a heat strain decision aid. This model deals directly with five major inputs: the clothing worn, the physical work intensity, the state of heat acclimation, the ambient environment (air temperature, relative humidity, wind speed, and solar load), and the accepted heat casualty level. In addition to predicting rectal temperature, heart rate, and sweat loss given the above inputs, our model predicts the expected physical work/rest cycle, the maximum safe physical work time, the estimated recovery time from maximal physical work, and the drinking water requirements associated with each of these situations. This model provides heat injury risk management guidance based on thermal strain predictions from the user specified environmental conditions, soldier characteristics, clothing worn, and the physical work intensity. If heat transfer values for space operations' clothing are known, NASA can use this prediction model to help avoid undue heat strain in astronauts during space flight.
Conventional Optical Polishing Techniques (1971)

A review of the present knowledge of conventional polishing techniques is presented, concentrating particularly on the pitch polishing technique for high precision optical surfaces. This technique still depends completely on the artistry of highly skilled opticians who have a largely intuitive understanding of the process. The aim of this article is to point out that the course of surface shape development during the polishing process can be explained in terms of available technical knowledge and consequently that an improvement of polishing technique, based on this knowledge, is feasible.
Simultaneous Calibrationless Determination of Zinc, Cadmium, Lead, and Copper by Flow-Through Stripping Chronopotentiometry (1999)

Zn, Cd, Pb and Cu are deposited in a porous flow-through electrode plated with mercury and then are stripped by constant current while the stripping time is measured. Since complete electrochemical deposition can be achieved, the analyte concentrations can be directly obtained from Faraday's laws i.e., the method is denoted as calibrationless. The influence of the deposition potential, stripping current, carrier electrolyte composition, Cu content and sample matrix was investigated. The optimum conditions are: deposition potential: –1600 mV, stripping current: 200 μA, carrier electrolyte: 0.1 mol/L sodium sulfate at pH 4–5. The dynamic range of the method is from about 0.1 ng/mL to few mg/mL. The repeatability of the method is 1–2 % in the optimum concentration range. The procedure was applied to the analyses of water samples, geological, and biological materials.
Microwave circuits (2007)

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3-Aminopropyltriethoxysilane as a promoter in the crosslinking of carboxylated nitrile rubber by surface-oxidized carbon black (1996)

The role of aminopropyltriethoxysilane in the interaction between ISAF carbon black and carboxylated nitrile rubber was studied by measurements of bound rubber, physical and dynamic mechanical properties of the vulcanizates, and Monsanto Rheometric studies on the rubber-filler mixes. It is believed that  NH2 groups of the silane interact with COOH groups of the rubber, while OC2H5 groups of the silane interact with OH groups on the filler surface. Weak rubber-filler bonds formed during mixing are converted into a crosslinked structure during high-temperature molding. The extent of crosslinking of the rubber phase by the active sites on the filler surface is greater in the case of oxidized ISAF carbon black, as compared to the nonoxidized grade. © 1996 John Wiley & Sons, Inc.
Increased Detection of Aβ Oligomers in the Cerebrospinal Fluid of Alzheimer s Disease: Fact or Artifact? (2012)

The peptides Amyloid beta 1-40 and 1-42 (A 40 , A 42 ) are physiological derivatives of the amyloid precursor protein (APP), a normal constituent of neuronal and glial membranes. A 40 and A 42