gebhart/patrepeval huggingface dataset:
The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression (1998)

Specification and differentiation of the cardiac muscle lineage appear to require a combinatorial network of many factors. The cardiac muscle-restricted homeobox protein Csx/Nkx2.5 (Csx) is expressed in the precardiac mesoderm as well as the embryonic and adult heart. Targeted disruption of Csx causes embryonic lethality due to abnormal heart morphogenesis. The zinc finger transcription factor GATA4 is also expressed in the heart and has been shown to be essential for heart tube formation. GATA4 is known to activate many cardiac tissue-restricted genes. In this study, we tested whether Csx and GATA4 physically associate and cooperatively activate transcription of a target gene. Coimmunoprecipitation experiments demonstrate that Csx and GATA4 associate intracellularly. Interestingly, in vitro protein-protein interaction studies indicate that helix III of the homeodomain of Csx is required to interact with GATA4 and that the carboxy-terminal zinc finger of GATA4 is necessary to associate with Csx. Both regions are known to directly contact the cognate DNA sequences. The promoter-enhancer region of the atrial natriuretic factor (ANF) contains several putative Csx binding sites and consensus GATA4 binding sites. Transient-transfection assays indicate that Csx can activate ANF reporter gene expression to the same extent that GATA4 does in a DNA binding site-dependent manner. Coexpression of Csx and GATA4 synergistically activates ANF reporter gene expression. Mutational analyses suggest that this synergy requires both factors to fully retain their transcriptional activities, including the cofactor binding activity. These results demonstrate the first example of homeoprotein and zinc finger protein interaction in vertebrates to cooperatively regulate target gene expression. Such synergistic interaction among tissue-restricted transcription factors may be an important mechanism to reinforce tissue-specific developmental pathways.
Prostate Cancer with Solitary Parotid Metastasis Correctly Diagnosed with Immunohistochemical Stains (1989)

A case of prostate cancer in which the parotid gland was the sole site of metastatic disease is presented. Special immunohistochemical stains of the excisional biopsy allowed for rapid, accurate diagnosis and appropriately directed successful therapy.
Application of a novel ultra-high resolution multi-detector CT in quantitative imaging of trabecular microstructure (2020)

The recently introduced UHR CT achieves improved correlation and reduced error in measurements of trabecular bone microstructure compared to conventional resolution CT. Future development of diagnostic strategies based on textural biomarkers derived from UHR CT will need to account for potential sensitivity of texture features to image resolution.
Automatisierte Höchstpräzisionsfertigungstechnologie für Mikrooptik-Baugruppen (2005)

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Highly scalable appearance-only SLAM - FAB-MAP 2.0 (2009)

We describe a new formulation of appearance-only SLAM suitable for very large scale navigation. The system navigates in the space of appearance, assigning each new observation to either a new or previously visited location, without reference to metric position. The system is demonstrated performing reliable online appearance mapping and loop closure detection over a 1,000 km trajectory, with mean filter update times of 14 ms. The 1,000 km experiment is more than an order of magnitude larger than any previously reported result. The scalability of the system is achieved by defining a sparse approximation to the FAB-MAP model suitable for implementation using an inverted index. Our formulation of the problem is fully probabilistic and naturally incorporates robustness against perceptual aliasing. The 1,000 km data set comprising almost a terabyte of omni-directional and stereo imagery is available for use, and we hope that it will serve as a benchmark for future systems.
Transmission friction in an electric mining shovel (2007)

Abstract Friction is a phenomenon present in all mechanical systems and is undesirable in estimation and control tasks. This paper explores the characteristics of friction in the transmission of an electric mining shovel, with a view to compensating for them. Experiments suggest that the transmission friction can be described by a Coulomb friction model with associated uncertainty on the friction force. The Kalman Inverse Filter is evaluated as a method for adaptively estimating the friction for motion of the bucket through free‐space. The friction estimates are consistent with experimental results. © 2007 Wiley Periodicals, Inc.
Optical breast shape capture and finite-element mesh generation for electrical impedance tomography (2011)

X-ray mammography is the standard for breast cancer screening. The development of alternative imaging modalities is desirable because mammograms expose patients to ionizing radiation. Electrical impedance tomography (EIT) may be used to determine tissue conductivity, a property which is an indicator of cancer presence. EIT is also a low-cost imaging solution and does not involve ionizing radiation. In breast EIT, impedance measurements are made using electrodes placed on the surface of the patient's breast. The complex conductivity of the volume of the breast is estimated by a reconstruction algorithm. EIT reconstruction is a severely ill-posed inverse problem. As a result, noisy instrumentation and incorrect modelling of the electrodes and domain shape produce significant image artefacts. In this paper, we propose a method that has the potential to reduce these errors by accurately modelling the patient breast shape. A 3D hand-held optical scanner is used to acquire the breast geometry and electrode positions. We develop methods for processing the data from the scanner and producing volume meshes accurately matching the breast surface and electrode locations, which can be used for image reconstruction. We demonstrate this method for a plaster breast phantom and a human subject. Using this approach will allow patient-specific finite-element meshes to be generated which has the potential to improve the clinical value of EIT for breast cancer diagnosis.
Application of Chicken Immune Sera to Identification of Mycoplasmas by the Filter Immunobinding Method. (1998)

Application of chicken immune sera to identification of Mycoplasma species by the filter immunobinding (FIB) method was investigated. Immune sera against type strains of 15 Mycoplasma species were prepared in chickens by inoculation with concentrated Mycoplasma organisms. Chicken immune sera, when absorbed in a broth medium and diluted in a blocking solution, showed a definite specificity with homologous Mycoplasma antigens by FIB. The identification results of field isolates of Mycoplasma gallisepticum and M. synoviae by FIB using absorbed chicken immune sera were consistent with those obtained by conventional tests based on biochemical properties and growth inhibition using rabbit immune sera. Chicken immune sera were evidenced to be useful for identification of Mycoplasma species when applied to FIB although they were not applicable in growth and metabolism inhibition tests.
<title>Utilizing fuzzy c-Shells for automatic approximate LV location for initialization of myocardial structure and function analysis algorthms</title> (1994)

Recently, fuzzy c-Shells algorithms have been proposed for spherical boundary detections. Only a few applications of the Fuzzy c-Shells algorithm have been explored. This paper proposes a new algorithm utilizing the Fuzzy c-Shells approach for detection of the approximate location of the left ventricle. The proposed technique has been successfully applied to 25 2-D magnetic resonance cardiac images and has located the left ventricles.
Performance of the ATLAS liquid argon forward calorimeter in beam tests (2013)

One of two ATLAS Forward Calorimeters, consisting of threemodules, one behind the other, was exposed to particle beams ofknown energies in order to study the detector performance with andwithout the presence of upstream material in the beam, and at theinner edge of the acceptance where shower energy containment isincomplete. Data were taken in the H6 beamline at CERN usingelectron and hadron beams with energies from 10 to 200 GeV.Results related to the intrinsic detector calibration, based on datataken with a minimal amount of material in front of the detector,have been previously published, but are updated here. This paperfocuses on studies of data taken with additional upstream materialin place. The effects of this additional material on the linearityand resolution of the response are presented. The response at theinner edge of the acceptance is also investigated. For all analyses,results based on a GEANT4 simulation of the beam-test setup anddetector response are also presented.
The Quest Language and System (1994)

tuples An abstract type is obtained by a tuple type which contains a type and a set of constants and operations over that type. . Let T = Tuple A::TYPE a:A f(x:A):Int end; ‡ Let T::TYPE = Tuple A::TYPE a:A f(x:A):Int end This abstract type can be implemented by providing a type, a value of that type, and an operation from that type to Int:
ChemInform Abstract: Recent Developments in Pyridazine and Condensed Pyridazine Synthesis (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Suppression of Streptococcus mutans in the Mouths of Humans by a Dental Prophylaxis and Topically-applied Iodine (1979)

A prophylaxis followed by three topical applications of an iodine-potassium iodide solution significantly reduced the levels of Streptococcus mutans in fissure and approximal plaques and in saliva. Reductions persisted 20--24 weeks after treatment in salivary and approximal samples. A prophylaxis alone exerted a small and temporary reduction of S. mutans in occlusal fissure plaque, but did not reduce the levels of this organism in approximal plaque or in saliva. A significant relationship existed between the levels of S. mutans in saliva and the proportions of this organism in plaque. The dorsum of the tongue does not appear to constitute a significant reservoir for S. mutans following disinfecting procedures.
Synthesis of peptide and pseudopeptide amides inhibiting the proliferation of small cell and epithelial types of lung carcinoma cells (1998)

Small cell lung cancer (SCLC) cell lines produce and secrete various peptide hormones, e.g. bombesin (BN)/gastrin releasing peptide (GRP) like peptides that are proposed to function as their autocrine growth factors. To inhibit the proliferative effect of these hormones we have synthesized short chain BN[7-14]-analogues replacing the C-terminal peptide bond by a methylene-amino (-CH2NH-) unit and introducing d-Phe or d-Ser into position 12. As several substance P (SP) analogues were found to inhibit the growth of SCLC cells, some short chain SP-analogues have been synthesized. (Pseudo)octapeptides were synthesized in solution, by fragment condensation using the DCC/HOPfp method. Fragments and SP-analogues were synthesized stepwise using pentafluorophenyl esters. The resistance to hydrolysis of the reduced peptide bond made permitted exact quantification of the Leuψ(CH2NH)Leu pseudopeptide in hydrolysates. The binding ability of both types of peptides to BN-receptors on Swiss 3T3 mouse fibroblast cells and their antiproliferative effect on NCI-H69 human SCLC cell line have been tested and compared with a short chain SP-antagonist pHOPA-d-Trp-Phe-d-Trp-Leu-Leu-NH2 (R) previously described as a potent inhibitor of SCLC proliferation. While BN-analogues showed weak activity in inhibition of proliferation of SCLC cells, SP-analogues 6: d-MePhe-d-Trp-Phe-d-Trp-Leuψ(CH2NH)-Leu-NH2 and 7: d-MePhe-d-Trp-Phe-d-Trp-Leu-MPA, in spite of greatly diminished affinity towards the BN-receptor, inhibited SCLC proliferation more effectively than R (6: IC50=2 μm, 7: IC50=5 μm and R: IC50=10 μm). Moreover, 6 inhibited the respiratory activity of SK-MES 1 epithelial type of lung carcinoma cells in proliferating but not in the quiescent state, suggesting that the antiproliferative effect of these compounds is not due to simple cytotoxicity. These short chain analogues of SP might be promising candidates as therapeutic agents in the treatment of SCLC. © 1998 European Peptide Society and John Wiley & Sons, Ltd.
A Simplified Approach to Analyze Complementary Sensitivity Tradeoffs in Continuous-Time and Discrete-Time Systems (2019)

Continuous-time and discrete-time complementary sensitivity Bode integrals (CSBIs) are investigated via a simplified approach in this note. For continuous-time feedback systems with unbounded frequency domain, the CSBI weighted by 1/ω <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is considered, where this simplified method reveals a more explicit relationship between the value of CSBI and the structure of the open-loop transfer function. With a minor modification of this method, the CSBI of discrete-time system is derived, and illustrative examples are provided. Compared with the existing results on CSBI, neither the Cauchy integral theorem nor the Poisson integral formula is used throughout the analysis, and the analytic constraint on the integrand is removed.
A New Family of Mo-Doped SrCoO<sub>3−δ</sub> Perovskites for Application in Reversible Solid State Electrochemical Cells (2012)

The effect of Mo doping on the crystal structure and thermal, electrical, and electrochemical properties of the SrCo1–xMoxO3−δ (x = 0.05, 0.1) system has been studied. The introduction of Mo as a substitution for Co in SrCoO3−δ leads to a change from a hexagonal to a tetragonal perovskite structure at room temperature. The electrical conductivity is largely enhanced by the introduction of Mo at intermediate temperature due to the stabilization of the 3D-perovskite structure. However, the increase in Mo content decreases the total conductivity probably due to partial disruption of the electronic pathway. The use of these materials as cathodes in a solid-oxide fuel cell (SOFC) and as anodes in a solid oxide electrolyzer (SOE) has been evaluated, showing low values of electrode polarization resistances in both configurations over the intermediate temperature range. Interestingly, better performance was obtained under anodic polarization conditions reaching overpotential values as low as 28 mV for a current density of 210 mA·cm–2 at 700 °C. The good performance of the SrCo1–xMoxO3−δ compounds in both cathodic and anodic conditions makes this system a promising candidate for reversible oxygen electrodes in cells that could operate as both SOFC and SOE.
Crystal Structure of the B Subunit of Escherichia coli Heat-labile Enterotoxin Carrying Peptides with Anti-herpes Simplex Virus Type 1 Activity (1999)

Two chimeric proteins, consisting of the B subunit of Escherichia coli heat-labile enterotoxin with different peptides fused to the COOH-terminal ends, have been crystallized and their three-dimensional structure determined. The two extensions correspond to (a) a nonapeptide representing the COOH-terminal sequence of the small subunit of herpes simplex virus type 1 ribonucleotide reductase and (b) a 27-amino acid long peptide, corresponding to the COOH-terminal end of the catalytic subunit (POL) of DNA polymerase from the same virus. Both proteins crystallize in the P41212 space group with one pentameric molecule per asymmetric unit, corresponding to a solvent content of about 75%. The overall conformation of the B subunit pentamer in the two chimeric proteins, which consists of five identical polypeptide chains, is very similar to that in the native AB complex and conforms strictly to 5-fold symmetry. On the contrary, the peptide extensions are essentially disordered: in the case of the nonapeptide, only 5 and 6 amino acids were, respectively, positioned in two monomers, while in the other three only 2 residues are ordered. The extension is fully confined to the surface of the pentamer opposite to the face that interacts with the membrane and consequently it does not interfere with the ability of the B subunit to interact with membrane receptors. Moreover, the conformational flexibility of the two peptide extensions could be correlated to their propensity for proteolytic processing and consequent release of a biologically active molecule into cultured cells.
FEL Oscillator for EUV Lithography (2014)

Abstract Not Provided
ChemInform Abstract: Synthesis of Benzotriazolo(1,2‐a)benzotriazole Derivatives as New High Density, Insensitive Energetic Materials. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Structure of Individual Variation in Miocene globorotalia (1990)

Analysis of probability distributions of individual organisms provides a common language to describe synchronic and diachronic diversity.When based on an appropriate quantitative description of morphology, this language can be used to explore the temporal component ofdiversity embedded in the fossil record.Miocene Globorotalia (planktonic foraminifera) from Deep Sea Drilling Project site 593 are described using two-point registration oflandmarks in two views (spiral and apertural) and medialaxis analysis of the shape of the final chamber.The equiangular spiral parameters e (the angle of increment), r (the expansion rate), and t (the rate of translation down the spiral axis) appear as principal components ofthe landmark data.Chamber shape variation is described by three principal components of medial-axis curvature.Partial-least-squares analysis demonstrates that the first components of within-morphospace variation also explain the patterns of correlation between the landmark and chamber-shape morphospaces.In the landmark morphospaces, the distribution ofsampled individuals is continuous and roughly elliptical with few stratigraphic changes.In the chamber-shape morphospace, the distribution is continuous but shows complex features beyond the elliptical; the occupied morphospace changes stratigraphically, but neither strict cladogenesis nor strict anagenesis explains the derivation ofnew morphologies.Exemplars of named morphospecies are scattered across these spaces with continuous variation among all forms.These names cannot be assumed to represent discrete entities.
Valence states of actinides in synthetic monazites. [For possible storage of high-level nuclear wastes] (1980)

The valence states of various actinides doped into the lanthanide orthophosphates (LnPO/sub 4/) have been investigated. Actinide-doped LnPO/sub 4/ single crystals were grown by means of a flux technique and the actinide valence states were determined by optical absorption spectrophotometry. Radiation damage effects were also studied in these systems. The lanthanide orthophosphates are found in nature in the form of the mineral monazite and synthetic analogs of this substance represent a promising primary containment medium for the isolation of high-level nuclear wastes.
Model Verification of Mixed Dynamic Systems (1982)

MOVER uses experimental data to verify mathematical models of mixed dynamic systems. The term mixed refers to interactive mechanical, hydraulic, electrical, and other components. Program compares analytical transfer functions with experiment.
The experimental determination of the calibrated S-parameters of a single resonant-slot array element (2002)

A simple and quick experimental method has been developed for experimentally determining the calibrated scattering parameters of a single resonant-slot array element. The obtained calibrated scattering matrix is defined at two planar interfaces directly coincident with the front and back surfaces of the metal plate surrounding the slot. This measurement method determines different scattering matrices for the same slot, depending on the type of waveguide and the specific waveguide mode used to feed it. An example of a calibrated transmission response of a single slot, excited by the fundamental TE/sub 11/ mode of the cylindrical cavity used to feed it on either side, is presented. The slot resonance appears to be very wide and there is hardly any transmission-phase lag at its center.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prolongation of Effects of Adrenal Cortical Secretion by Ascorbic Acid: Proposed Mechanism of Action. (1952)

SummaryThe influence of ascorbic acid treatment on the hematologic effects of cortisone and of ACTH was investigated. The vitamin (plus hormones) prolongs these effects beyond that in animals which receive saline + hormones. These data suggest that the circulating titer of cortical hormone is maintained for long periods by vitamin treatment. This observation is discussed in relation to previous findings, and a mechanism proposed for the relationship of ascorbic acid to pituitary-adrenal activity.
An Isotropic Algorithm for Solving Maxwell's Equations in 2D (2008)

A popular time evolution algorithm for solving Maxwell's equations for electromagnetic problems is the Yee's finite difference time domain (FDTD) algorithm. This algorithm introduces a non physical algorithmic anisotropic dispersion error and limited stability range. A new improved algorithm with isotropic dispersion error, better stability and faster execution is introduced in this paper. In this study, we compared the results of our improved isotropic algorithm, for simple and well-known problems, to that of the exact solution and that of the Yee algorithm. These comparisons show more accurate results for our improved isotropic algorithm compared to that for the Yee Algorithm. For practical application problems where solutions are too complicated to be solved analytically, we compared our algorithm to that of Yee and found that our algorithm simulate such problems faster and with smaller error.
Vers le traitement génétique des hémoglobinopathies (2000)

La drepanocytose et la b-thalassemie majeure sont des maladies pour lesquelles un traitement genetique est en principe approprie. Fort attendu, le traitement genetique des hemoglobinopathies souleve de nombreuses questions, aux confins de la biologie cellulaire, de la genetique, de la technologie du transfert de gene, et de la biologie de la transplantation. Des questions fondamentales restent a resoudre, particulierement en matiere de manipulation des cellules souches hematopoietiques, d’efficacite de transfert de gene dans ces rares cellules, et de regulation de l’expression des transgenes. L’eventail des approches therapeutiques proposees s’elargit, au-dela du concept original base sur l’introduction du gene de la b-globine dans les cellules hematopoietiques, soit par transfection, soit par transduction virale. La reparation des mutations ponctuelles de l’ADN chromosomique ou meme de l’ARN, ainsi que des approches dites indirectes visant a stimuler l’expression de la g-globine endogene, sont activement explorees. Cependant, la guerison de la drepanocytose, comme celle de la thalassemie majeure, n’a pas encore ete obtenue dans un modele murin. L’essor des therapies genetiques est porteur d’espoir, mais il ne faut pas sous-estimer le defi pose par l’application clinique de demonstrations de principe accomplies dans les laboratoires de recherche.