gebhart/patrepeval huggingface dataset:
Extensively Calcified Hemangioma of the Diaphragm with Increased 99mTc-Hydroxymethylene Diphosphonate Uptake. (2000)

A 31-year-old woman visited an out-patient clinic, because of low-grade fever and general fatigue. She was referred to our hospital and admitted for examination of an abnormal shadow which had been found on the chest radiograph. She had experienced faint right lateral chest pain several times on the deep inspirations. Chest radiography showed a mass shadow with calcification in the right lower lung field on the mediastinal side. Chest radiographic computed tomography showed a 6x6 cm tumor in the right lung field. There were low-density areas with septae inside the tumor. Bone scintigraphy showed extremely high uptake of (99m)Tc-HMDP in the tumor. After surgical resection and pathological examination, we concluded that the tumor was an extensively calcified benign hemangioma of the diaphragm.
Hydrogen Transfer Reduction of Aldehydes with Alkali-Metal Carbonates and Iridium NHC Complexes (2004)

Some neopentyl-substituted NHC iridium complexes catalyze the reduction of a variety of aldehydes and even enolizable aldehydes by hydrogen transfer from refluxing 2-propanol with alkali-metal carbonate bases. Imidazole and 1,2,4-triazole complexes had comparable activities. The aldehydes could also be reduced more slowly using a mild carbonate base and no iridium complex.
Portal Vein Thrombosis during Eltrombopag Treatment for Immune Thrombocytopenic Purpura in a Patient with Liver Cirrhosis due to Hepatitis C Viral Infection (2013)

Portal vein thrombosis is a rare, aggressive and life-threatening complication of liver cirrhosis (LC). Eltrombopag is effective for the treatment of chronic hepatitis with thrombocytopenia, and portal vein thrombosis at this time has rarely been reported. We describe the case of a 78-year-old woman who suffered from LC due to hepatitis C viral infection. The patient developed immune thrombocytopenic purpura (ITP) that was diagnosed on the basis of nasal bleeding, progressive severe thrombocytopenia, elevation of platelet-associated IgG (PAIgG), no response to the transfusion of platelets and no abnormal findings on bone marrow biopsy. Although we first administered prednisolone (0.5 mg/kg/day), there was no recovery of platelet function and the nasal bleeding persisted. Subsequently, we administered eltrombopag for refractory ITP at a dose of 12.5 mg/day, and the thrombocytopenia gradually improved. Fifty-four days after the start of eltrombopag therapy, she developed portal vein thrombosis. Eltrombopag was stopped immediately, and antithrombin III was administered for prophylaxis against further portal vein thrombosis. Despite these treatments, there were subsequent deep vein and pulmonary artery thromboses. We then administered heparin for recanalization of the thrombi. One month after the initiation of heparin, there was recanalization as well as improvements of the portal vein, deep vein and pulmonary artery thromboses. There was no further thrombosis progression after switching from heparin to warfarin therapy. Our case suggests that eltrombopag may increase the risk of portal vein thrombosis ; therefore, this drug must be used carefully in the treatment of ITP in patients with LC due to hepatitis C viral infection.
Stress Response in Bacteria: Heat Shock (2003)

Abstract Terminology Retrospective and Definitions Beyond Cells Properties Heat Shock and Other Stressors Heat‐Shock Proteins Regulation Regulatory Circuits and Networks Proteolysis Chaperones and Proteases in Regulation New Looks of an Old Theme Thermotolerance and the Future
O4‐03‐01: Age‐dependent impairment of cognitive and synaptic function in transgenic mouse model of tau pathology (htau mouse) (2009)

A hallmark feature of Alzheimer's disease pathology is the presence of neurofibrillary tangles (NFTs), which are intracellular aggregates of conformationally abnormal and hyperphosphorylated tau. The presence of NFT in the neocortex is associated with impairments of cognitive function, supporting a central role for tau in dementia. The significance of the accumulation of NFT for neuronal and cognitive function is still obscure. Objective (s): To investigate whether tau accumulation and aggregation is involved in inducing cognitive impairments by affecting synaptic function, we studied synaptic and cognitive functions of the htau mouse. The hTau mouse develops tau pathology similar to observed in AD in its distribution and its age-dependent development. Animals: htau mice and age-matched wild type mice: male (C57BL/6 J) ages 4 and 12 months. Electrophysiology: extracellular field excitatory postsynaptic potentials (EPSPs) evoked at the CA3-CA1 synapse were recorded to assess basal synaptic transmission (input-output curve and paired pulse facilitation) and long term potentiation (LTP). Behavior: visual recognition memory was measured by an object recognition memory test that measured spontaneous preference for a novel object compared to a familiar object. The spatial memory was assessed by the Morris water maze test (MWM). Htau mice develop age-dependent cognitive and physiological impairments. 4 months-old htau mice, with early stage of tau pathology (pre-tangles) are unaffected behaviorally and physiologically. Concurrent with the development of moderate tau pathology in the forebrain, 12 months-old htau mice develop learning and memory deficits. 12 months-old htau mice show cognitive deficits in object recognition and spatial memories which are associated with cortical and hippocampal dysfunction, precisely the brain regions affected by tau pathology. Basal synaptic transmission and induction of LTP with high frequency stimulation (HFS), but not theta burst stimulation, are perturbed in hippocampal CA1 region of old but not young htau mice. In addition, at 12 months htau mice had diminished charge transfer during HFS as a result of the inability of Schaffer collateral fibers to sustain high frequency activity. Our results suggest that tau pathology may underlie an age-dependent learning impairment through disruption of synaptic function.
Serum IgA rheumatoid factor and pyridinoline in very early arthritis as predictors of erosion(s) at two years: A simple model of prediction from a conservatively treated community‐based inception cohort (2010)

This model, using serum IgA-RF and pyridinoline concentrations, was able to predict≥1 erosion(s) at 2 years in very early arthritis patients.
Two-Dimensional Method for Calculating Separated Flow in a Centrifugal Impeller (1975)

A method of calculating a two-dimensional incompressible and inviscid flow within a centrifugal impeller where the flow separates from the suction side has been developed. Based on experimental observation it has been assumed that mixing of the throughflow with the separated region is suppressed. After a description of the calculation method, which is rather unusual, some results are presented and the implications discussed. The possibility of extending the method to handle compressible flow is outlined.
Erratum: asthma in the elderly: what we know and what we have yet to know (2014)

This article was originally published online on 18 June 2014 Following the publication of our article [1.Yáñez A. Cho S.H. Soriano J.B. Rosenwasser L.J. Rodrigo G.J. Rabe K.F. Peters S. Niimi A. Asthma in the elderly: what we know and what we have yet to know.World Allergy Org J. 2014; 7: 8Abstract Full Text Full Text PDF PubMed Scopus (95) Google Scholar], we noticed that Dr Flavia C. L. Hoyte had inadvertently been omitted from the author list. FCLH declares she has no conflicts of interest. The author list has now been corrected and the amended authors contributions section included below. AY initiated and led the development of the paper as primary author, contributing to all of the sections and unifying the document. SCH and STH were co-project leaders. SHC wrote the Introduction. JC and CEB wrote on the impact of asthma. LPB and GWC wrote on management of asthma. RK, FCLH, PB, LF, AK, KR, and LR wrote on the aging lung. DKL, SHC, SP, and GJR wrote on diagnosis. JBS wrote on life expectancy. All authors reviewed and approved the final document. Asthma in the elderly: what we know and what we have yet to knowWorld Allergy Organization JournalVol. 7PreviewIn the past, asthma was considered mainly as a childhood disease. However, asthma is an important cause of morbidity and mortality in the elderly nowadays. In addition, the burden of asthma is more significant in the elderly than in their younger counterparts, particularly with regard to mortality, hospitalization, medical costs or health-related quality of life. Nevertheless, asthma in the elderly is still been underdiagnosed and undertreated. Therefore, it is an imperative task to recognize our current challenges and to set future directions. Full-Text PDF Open Access
Power System Dynamic Performance Measured by Phasor Measurement Unit (2007)

In recent years, there has been an increasing interest in monitoring and analyzing dynamic performances of power systems, such as observation of power system oscillations and evaluation of machine parameters. However, in Japan, there was little observation as a whole power system. In this paper the authors present a global monitoring system of power system dynamics by using the synchronized phasor measurement of demand side. Authors have placed phasor measurement units (PMU) connected to 100 V outlets in some universities in Japan and been researching into oscillation characteristics in power systems. Phasor measurements are synchronized based on the global positioning system (GPS) and measurement data are transmitted via Internet. Some oscillative features and variation of phasor in a day, a week or a year are analyzed using the acquired data. The purpose of this paper is to show a power system dynamic performance by the use of measurement data at an unexpected disturbance and monitors a global and a local oscillation mode.
Optical Performance of Conical Windows for Concentrated Solar Radiation (1994)

Radiative energy transfer through a truncated cone window with a back-plane reflector is considered. This geometry is proposed for a high-pressure direct-radiation (volumetric) central solar receiver for use in combined-cycle electricity generation. The transmission and loss characteristics, computed by ray-tracing, are parameterized by the angle of incident radiation relative to the cone axis. The overall performance of the window is an integral of the angle-dependent transmission data, weighted by the actual distribution of input radiation, over all incidence angles. This parameterization provides insight and assists in tailoring of the window geometry to different solar collection methods. Results are presented for several window geometries. Overall window performance is presented for a dish-type distribution of input radiation.
Surgical Experience and Complications During Endonasal Sinus Surgery (1999)

The beginner enjoys the most effective type of assistance, in the form of personal guidance of an experienced surgeon who is constantly present during the first 30 operations, and who should then be readily available during the next 70 operative procedures. The use of multimedia software appears to be helpful, though its actual value still remains to be determined. The experienced surgeon in particular must be willing to exercise repeated self-criticism to keep his or her rate of complications to a minimum.
Internet Service in Developing Regions Through Network Coding (2009)

The availability of Internet services brings many benefits to developing regions, yet Internet deployment levels in these regions remain staggeringly low. In this work we investigate how existing cellular deployments, which have enjoyed more rapid and wider deployment than client Internet infrastructure, could be used to provide very low cost Internet services in underdeveloped rural areas. We propose a new service model in which traffic is delivered over multihop client-to-client connections that are coordinated by end-to-end control traffic exchanged over cellular infrastructure. To enable this scheme in low client density rural settings, we propose a novel data forwarding mechanism for opportunistic space-time paths. To explore multiple opportunistic paths, but without the high forwarding cost of replicating data on these paths, we use network coding and send only a fraction of the data on each path. Through extensive OPNET simulations we show that globally coordinated opportunistic forwarding enables service acceptable to most applications at only a fraction of cellular infrastructure load. We argue that the reduced load on the cellular infrastructure allows additional users to share services and cost of the network and has the potential to lower the per user price of data services in developing regions.
Thrombolytic therapy and acute aortic dissection. (1992)

Thrombolytic (tissue plasminogen activator) and antithrombotic treatment (heparin and aspirin) were given to a 47-year-old man with an acute type II aortic dissection presenting as an acute anterior myocardial infarction. During treatment he developed cardiac tamponade and an ischaemic stroke. Transoesophageal echocardiography (but not computed tomographies of the chest) revealed the correct diagnosis. After surgical repair (Bentall procedure) there was a complete recovery.
Efficacy of a high bioavailable cetylpyridinium chloride mouthrinse over a 24-hour period: a plaque imaging study. (2005)

These results support the strong retention and lasting antiplaque efficacy of high bioavailable CPC mouthrinse and suggest that the plaque biofilms formed during CPC use are susceptible to more efficient debridement.
Phenyl 3-fluorobenzoate (1994)

Although the title compound, C 13 H 9 FO 2 , differs from phenyl benzoate only in the presence of an F atom in the molecular structure, their molecular conformations and assemblies are quite different. It could be concluded that the change is due to the presence of the F atom
Detection of Mycobacterium avium Subspecies paratuberculosis in Crohn's Diseased Tissues by In Situ Hybridization (2001)

The demonstration of DNA from CWD forms of M. paratuberculosis in this limited number of CD tissues further supports and confirms previous reports of its association with the granulomatous type of the disease.
Effect of Y-25130, a selective 5-HT3 receptor antagonist, on the intestinal fluid secretion in rats. (1993)

We studied the effect of Y-25130 on the intestinal fluid secretion induced by 5-HT and cholera toxin in rats. 1) Net fluid secretion was increased dose-dependently by intramesenteric artery infusion of 5-HT (1-10 micrograms/min). 2) Y-25130 (0.01-1 mg/kg, i.v.) inhibited the net fluid secretion induced by 5-HT (3 micrograms/min). Granisetron and ondansetron also inhibited the net fluid secretion induced by 5-HT. 3) Methysergide did not inhibit the fluid secretion, and neither atropine nor tetrodotoxin inhibited it. 4) Cholera toxin (1-10 micrograms/2 ml into jejunal loops) caused profuse net fluid secretion. 5) Y-25130 (1 mg/kg, i.v.) inhibited the net fluid secretion induced by cholera toxin (3 micrograms/2 ml). Granisetron was inhibitory and ondansetron tended to inhibit the cholera toxin-induced secretion. These results suggest that 5-HT may increase the net fluid secretion through 5-HT3 receptors, and cholera toxin-induced fluid secretion may be at least partially mediated by 5-HT3 receptors. It is expected that Y-25130 may be useful for treating secretory diarrhea in humans.
Knockout and knockin of the beta 1 exon D define distinct roles for integrin splice variants in heart function and embryonic development (1998)

The beta1D integrin is a recently characterized isoform of the beta1 subunit that is specifically expressed in heart and skeletal muscle. In this study we have assessed the function of the beta1D integrin splice variant in mice by generating, for the first time, Cre-mediated exon-specific knockout and knockin strains for this splice variant. We show that removal of the exon for beta1D leads to a mildly disturbed heart phenotype, whereas replacement of beta1A by beta1D results in embryonic lethality with a plethora of developmental defects, in part caused by the abnormal migration of neuroepithelial cells. Our data demonstrate that the splice variants A and D are not functionally equivalent. We propose that beta1D is less efficient than beta1A in mediating the signaling that regulates cell motility and responses of the cells to mechanical stress.
<i>In situ</i> identification of host derived infiltrating cells in chemically induced fibrosarcomas of interspecific chimeric mice (1986)

Chimeric mice have been used to investigate the cellular origin of chemically induced tumors. Interspecific chimeras were formed between the Ha/ICR strain of Mus musculus and Mus caroli. The normal tissues of the chimeric mice were composed of a mixture of cells which originated from each of the 2 species. The species of origin of the cells was determined both histologically with in situ hybridization using a DNA probe which recognizes M. musculus satellite DNA and by electrophoretic analysis of phosphoglycerate kinase-1 (PGK-1) isozyme expression. The 2 parental species, M. musculus and M. caroli, had comparable levels of inducible cytochrome P-450-dependent mixed function oxidase activity. Subcutaneous fibrosarcomas were induced with 3-methylcholanthrene. Electrophoretic analysis of many samples from the tumors revealed that some demonstrated both isozymes of PGK-1. However, extensive sectioning with subsequent in situ hybridization revealed that the only cells of mixed genotype were small, infiltrating inflammatory cells. These results confirmed PGK-1 analysis of the tissue culture cell lines derived from the tumors. This is the first report of direct visualization of the lineage origin of various cellular components in chemically induced tumors in a mosaic system and supports the contention that, while the neoplastic cells are clonal in origin, the tumors also contain non-neoplastic "host" cells which are derived from both sets of parents.
ChemInform Abstract: ANTIINFLAMMATORY SYDNONES PART 1 (1975)

Abstract Aus den Aminen (I) und den α‐Halogencarbonsäuren (II) entstehen die Glycinsäuren (III),die mit Nitrit/HCl in Chloroform über die Nitrosoverbindungen (IV) in die Sydnone (V) übergehen.
Decomposition ofLignocellulose byCyathus stercoreus (Schw.) deToniNRRL 6473, a"White Rot"Fungusfrom Cattle Dung (1980)

Fungi capable ofefficiently degrading thelignocellulosic complex ofgramineous agricultural residues toitsfractions (e.g., lignin, cellulose, hemicellulose) canbeisolated fromruminant dungingrasslands (D.T.Wicklow, R.W.Detroy, andS.Adams,Mycologia, inpress). In approaching thisresearch, Wicklow etal.(in press) recognized thatcertain late-appearing fungal colonists probably haveevolved enzyme systems specially adapted forattacking thesubstructures ofnative lignins andlignocellulose complexes indigested gramineous residues. Central tothis reasoning arethefacts thatnatural lignins ofgrasses areknowntodiffer fromthose ofother plant taxaintherelative frequency of certain chemical substructures (4-6) andundigested lignocellulose fromgrasses isaprincipal component ofcattle dungingrasslands. Thisstudy examines theability ofCyathus stercoreus (Schw.) de Toni,Nidulariaceae (bird's nestfungi), todifferentially modify the lignin andcellulose components ofwheatstraw (WS). C.stercoreus growsinandformsbasidiocarps onthesurface ofold, decomposed cowor horsedungandisworldwide initsdistribution
Crossline-like Structure Accumulates as Fluorescent Advanced Glycation End Products in Renal Tissues of Rats with Diabetic Nephropathy. (1996)

Although formation of characteristic fluorescence (Exmax/Emmax:370/440nm) in renal tissues has been known to be enhanced in diabetic model rats and the natural fluorophores have been thought as advanced glycation end products (AGEs), these structures remain unclear to this date. Since we had already isolated Crossline derivatives as the main fluorescent AGE-products formed in a sugar-amine-model system in vitro, we tried to determine whether crossline-like structure can be found in renal tissues of rats with diabetic nephropathy. Specific polyclonal antiserum against crossline-structure and its affinity chromatography-purified antibody were prepared. The purified antibody did not recognize native rat serum albumin (RSA), but it recognized RSA modified by prolonged incubation with high concentration of glucose (AGE-RSA) as well as the crossline-hapten. The immunoreactivity of AGE-RSA was completely blocked by co-incubation with crossline-derivative. These results confirm immunochemically that in vitro-prepared AGE-proteins contain crossline-like structure. Similarly, crossline-like structure in AGE-proteins in vivo was examined immunohistochemically. In streptozotocin-induced diabetic rats, both crossline-like immunoreactivity and fluorescence (Ex/Em:370/440 nm) of renal tissues increased, and the levels rose further with progression of diabetic nephropathy. Crossline accumulation was observed in specific renal tissues such as glomeruli (basement membrane and mesangium), tubules, and Bowman's capsules. Although the contribution of crossline-like substance(s) to total fluoroescence in diabetic renal tissues has not as yet been quantitatively determined, our results provide evidence that crossline accumulation occurs in renal tissues of rats in association with the initiation and/or progression of diabetic nephropathy.
Cellular origin of the dermal‐epidermal basement membrane (1993)

The basement membrane underlying epithelium of skin is generally believed to be of epithelial origin, but a mesenchymal contribution to the basement membrane has not been directly examined. The purpose of this study was to directly evaluate both epithelial and mesenchymal contributions to the basement membrane. Fetal bovine keratinocytes cultured on the surface of collagen gels in the absence of fibroblasts did not produce an ultrastructurally recognizable basement membrane; however, when these cells were cultured in the presence of dermal fibroblasts a basement membrane at the keratinocyte-fibroblast interface was produced after 1 week which was very similar in biochemical composition and ultrastructural appearance to dermal-epidermal basement membrane in human skin. When dual species cultures of bovine keratinocytes and human fibroblasts were analyzed by indirect immunofluorescent microscopy (IF)1 with human specific antibodies against basement membrane components, dermal fibroblasts were shown to synthesize and deposit type IV collagen, type VII collagen, and laminin in a linear manner into the basement membrane zone. Fetal bovine keratinocytes cultured in the presence or absence of fibroblasts synthesized and deposited type IV collagen, type VII collagen, laminin, K-laminin, kalinin, and basement membrane associated heparan sulfate proteoglycan (HSPG) into the underlying basement membrane zone. In organ culture, a subpopulation of fibroblasts initially migrating from human foreskin explants was found to stain strongly for types VII and IV collagen and laminin by IF whereas after subculture all cells showed a uniform low staining. Based on these observations we propose that differentiated fibroblasts exist adjacent to epithelial tissues in vivo which produce basement membrane components and assist in basement membrane assembly.