gebhart/patrepeval huggingface dataset:
Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer—a clinical biomarker discovery and validation study (2019)

TriMeth enables detection of early-stage colorectal cancer with high sensitivity and specificity. The reported results underline the potential utility of DNA methylation-based detection of circulating tumour DNA in the clinical management of colorectal cancer.
Comparisons of Seated Postures between Office Tasks (2008)

Seating is an active area of ergonomics research; however, little research has been performed that evaluates seated body postures for a variety of tasks and chairs. The goal of this study was to evaluate the effects of common office tasks on head, upper extremity, torso, hip, and leg postures. Prolonged awkward postures may contribute to musculoskeletal pain and disorders. Twenty-five participants performed four office tasks using four office chairs while postures were recorded using a 3D optical marker system. The tasks were typing on a desk fixed at 73.7cm (29“), typing with the desk adjusted to be slightly above elbow height, reclined movie watching, and a forward leaning writing task. Head angle, pelvis-to-head angle, thoracic cage angle, and pelvis angle were all significantly different between tasks ( p = <0.0001). This method for full body posture measurement will allow further research into the effects of tasks and chairs on seated posture.
Hierarchically structured carbon and silica by chemical foaming (2018)

Foamed organic/silica hybrid materials are synthesized<italic>via</italic>cationic polymerization of organic carbonates with twin monomers. They are converted into hierarchically structured carbon and silica.
Residential Air-Distribution Systems: Interactions with the Building Envelope (1992)

Residential air distribution systems, used both for heating and cooling and less commonly for ventilation, have important interactions with the building envelope.These systems can either be enclosed within the envelope or pass outside the envelope (in which case they represent an extension of the envelope).This paper addresses the three major types of interaction between air distribution systems that pass outside the envelope and single-family buildings: (1) duct leakage and duct conduction when the distribution fan is off, which act like a thermal bridge in the envelope; (2) duct leakage during system operation, which creates large changes in the quantity and location of air infiltration and exfiltration through the envelope; and (3) supply/return flow imbalances within individual zones during fan operation, which create elevated envelope pressure differentials, infiltration rates, and ex filtration rates.A simulation tool that was developed to take into account all of these interactions is presented and applied.The simulation tool, based upon the DOE-2 thermal simulation model, a multi-zone airflow network model (COMIS), and ~ an equipment model for the ducts, is used to examine the magnitude of all three interactions.The interaction issues examined include air infiltration/exfiltration magnitude and location, overall thermal exchange when the system is off, and air exchange when the system is operating, with and without internal doors closed.Th~ most surprising result of the analyses presented was that the thermal siphon effect for perfectly sealed ducts was shown to have an impact on the heat exchange between the house and unconditioned spaces that can be more than four times larger than that due to typical duct leakage when the fan is not in operation.This result suggests that this issue merits more careful examination than it has received in the past.'" It should he noted that some manufacturers recommend continuous fan operation.
Selective color tone adjustment for advanced television systems (1994)

One of the subtle problems in color image processing is the difficulty of adjusting specific color tones in the image without affecting all other colors. The usual method is to adjust the primaries so as to produce as realistic as possible skin tones, and at the same time balance the rest of the colors dose to their natural appearances. The reality, however, is that a balance of all color tones to their natural appearances by just adjusting the three primaries is not always a possible task. An alternative approach is to selectively adjust specific color tones without altering the color balance in the rest of the image. Such a scheme can be referred to as selective color tone adjustment. It is also possible to selectively sharpen or blur a specific color by selective color filtering. One application of this method is in the production of true-to-life colors in television systems. Other applications could include special effects such as soft blur or color change of specific subjects, etc. The authors present a scheme for color classification and examine its application in selective color tone adjustment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Jeanne Sheffield, MD (2016)

Dr. Jeanne Sheffield is the Director of the Maternal-Fetal Medicine Division and Professor at the Johns Hopkins Medicine Department of Gynecology and Obstetrics. Her areas of clinical and research expertise include medical and surgical complications of pregnancy with a focus on infectious diseases in pregnancy. Dr. Sheffield received her undergraduate degree from the University of Notre Dame and earned her medical degree from the University of Alabama at Birmingham. She did her residency in Obstetrics and Gynecology there and then completed a Maternal-Fetal Medicine fellowship at the University of Texas Southwestern Medical Center in Dallas, Texas. She is board-certified in obstetrics and gynecology and also maternal-fetal medicine. She joined the Johns Hopkins faculty in 2015. Dr. Sheffield serves on several national boards and committees and is a member of the American College of Obstetrics & Gynecology (ACOG), the Alpha Omega Alpha (AOA) the American Gynecologic and Obstetrics Society (AGOS), the Society of Maternal-Fetal Medicine and the Infectious Disease Society of Obstetrics and Gynecology (IDSOG). She is currently on the Board of Directors for the Society of Maternal-Fetal Medicine and serves on the MFM Division of the American Board of Obstetrics and Gynecology. She works with the National Institutes of Health for both national grant reviews and safety monitoring boards and has served on several working groups focusing on improving the pregnancy research infrastructure. She acts as a pregnancy consultant to the Centers for Disease Control and Prevention and is an active member of the National Vaccine Advisory Committee.
Conditioned pilots for ISI channels (2013)

One of the proposals to increase the spectral efficiency of the DVB-S2 standard is based on time-frequency packing. This technique causes intersymbol and interchannel interferences to arise, requiring a significant growth of the number of pilots used to carry out frequency and phase synchronization. Therefore, a new pilot design will be introduced and suited optimal and suboptimal reduced-complexity algorithms derived. We will show that the proposed pilot strategy may outperform the classical one in terms of bit error rate and spectral efficiency.
A comparison of factors affecting the production of two bacteriocins from lactic acid bacteria (1992)

The effect of tryptone, yeast extract, Tween 80 and initial pH on the production of enterocin 1146 and lactocin D, two bacteriocins produced by lactic acid bacteria, was studied in a basal buffered medium (tryptone‐yeast extract‐tween, TYT) using factorial experiments and empirical modelling. Production of enterocin 1146 was affected by pH, yeast extract and Tween 80 and to a lesser degree, by the initial pH of the medium. On the basis of the predictions of the models developed, three TYT media (TYT10, TYT11 and TYT30) were designed to maximize bacteriocin production while minimizing the amount of peptides in the medium. Growth and bacteriocin production by Enterococcus faecium DPC 1146 (enterocin 1146), Lactococcus lactis subsp. lactis biovar diacetylactis DPC 3286 (lactocin D) and Lact. lactis subsp. cremoris LMG2130 (lactococcin A) was compared in TYT media and seven other culture media (Elliker lactic broth, M17, M17 dialysate, MRS, tryptose phosphate, tryptone yeast extract broth, yeast glucose Lemco broth). Bacteriocin production in TYT media was comparable with that in M17 and MRS, which had a higher peptide content. TYT30 allowed good production of enterocin 1146 and lactocin D while TYT11 proved acceptable for all the strains tested.
HDI-15 Effect of Mechanical Design of the Suspension on Dynamic Loading Process (2003)

In this study, we show that if the preload between the load-dome and flexure is too low, the slider can oscillate causing the corners of the slider to contact the disk multiple times even though the slider is a few microns away from the disk. In addition, the slider can be sucked down towards the disk resulting in a complete separation of the load-dome from the flexure assembly leading to uncontrolled loading conditions. Hence, the suspension must be carefully designed to suppress slider oscillation and to ensure that the load-dome does not separate significantly during the loading process.
Clinical characteristics and risk factors for septic shock in patients receiving emergency drainage for acute pyelonephritis with upper urinary tract calculi (2012)

APN associated with upper urinary tract calculi is a severe disease that should be treated with caution, particularly when risk factors are present.
Realizing the promise of visualization in the theory of computing (2005)

Progress on a hypertextbook on the theory of computing is presented. The hypertextbook is a novel teaching and learning resource built around web technologies that incorporates text, sound, pictures, illustrations, slide shows, video clips, and---most importantly---active learning models of the key concepts of the theory of computing into an integrated resource. Active learning models currently exist for finite state automata, regular expressions, regular grammars, the pumping lemma for regular languages, context- free grammars, LL(1) parsing, and program execution. The seamless interweaving of these components into a browser-ready whole will help realize the goal of integrating visualization aids into theory courses.
Evidence for a Marking Pheromone Deterring Repeated Oviposition in Apple Maggot Flies1,2 (1972)

Immediately following oviposition (but rarely following attempted boring without oviposition), apple maggot, Rhagoletis pomonella (Walsh), females were observed to circle around the fruit for about 30 seconds, dragging their fully-extended ovipositors on the fruit surface behind them. The results of field and laboratory experiments indicated that during such dragging, a pheromone deterring repeated boring is deposited on the fruit surface. Where the fruit was small (15-mm-diam cherries) and the drive to oviposit moderate (as among the field population), there was almost total deterrence for 4 days (i.e. until termination of the experiment) to any repeated boring in a fruit so marked by a single female. Where the fruit was large (55-mm-diam apples) or the drive to oviposit strong (as among laboratory flies deprived of oviposition sites), marking by only one female was insufficient to elicit strong deterrence. It is suggested that deposition of this marking pheromone is an important factor mediating uniformity in egg dispersion among available fruits, and that the amount of fruit surface area marked following a single oviposition is related to the amount of food or space required by one larva to grow to maturity. The potential utility of the pheromone in population suppression is also discussed.
Studies on tomaymycin. III. Syntheses and antitumor activity of tomaymycin analogs. (1983)

The syntheses and antitumor activity of tomaymycin analogs are described. Structural modification of such parts of tomaymycin as the ethylidenepyrrole ring, animal bond, and substituents of the benzene ring are discussed.
High-power passively mode-locked semiconductor lasers (2002)

We have developed optically pumped passively mode-locked vertical-external-cavity surface-emitting lasers. We achieved as much as 950 mW of mode-locked average power in chirped 15-ps pulses, or 530 mW in 3.9-ps pulses with moderate chirp. Both lasers operate at a repetition rate of 6 GHz and have a diffraction-limited output beam near 950 nm. In continuous-wave operation, we demonstrate an average output power as high as 2.2 W. Device designs with a low thermal impedance and a smooth gain spectrum are the key to such performance. We discuss design and fabrication of the gain structures and, particularly, their thermal properties
Baseline (BL) radiographic characteristics and severe pulmonary hemorrhage (SPH) in bevacizumab (BV)-treated non-small cell lung cancer (NSCLC) patients (pt): Results from ARIES, an observational cohort study (OCS). (2010)

7619 Background: BV prolongs progression free and overall survival in advanced NSCLC pts. ARIES, a prospective OCS, evaluates BV clinical outcomes in a real world setting. Post hoc analyses from randomized controlled trials suggest location and cavitation as potential risk factors for SPH, a serious and often fatal adverse event (AE). ARIES presents a unique opportunity to independently evaluate BL tumor characteristics and correlate with SPH. Methods: Pts with advanced nonsquamous NSCLC on first-line chemotherapy and BV enrolled. No doses, regimens or assessments were prespecified. Data were collected electronically at BL and quarterly. SPH were reported expeditiously. BL CT scans were requested for all pts and reviewed by an independent review facility (IRF). Results: NSCLC enrollment completed 06/2009. As of 09/2009, 1,970 pts had median follow-up of 9.6 mo. The IRF reviewed BL scans of 1,881 pts; 1,470 (78%) had ≥ 1 BL measurable (meas) tumor (≥ 0.5cm) and 49% (718) were central; 67% had largest tumor size ≥ 3 cm; 14% had cavities and 10% had > 1 cavity. BL tumor characteristics were generally similar across subpopulations (age ≥ 70, PS ≥ 2, pts with CNS mets). Pts with a history (Hx) of hemoptysis (n = 105) had more centrally located tumors, fewer numbers of meas tumor, and larger cavity size. There are 15 (0.8%) reported SPH events to date; 2 pts had no BL CT scan submitted and 2 pts with BL scans had no meas tumor (1 had Hx of hemoptysis). Of the remaining 11 pts with SPH: 8 had central tumors; 1 had cavitation (1.2 cm); 0 were on anticoagulants at BL; largest tumor size ranged from 1.8-11.6cm. There was 1 SPH in pts with ≥ 1 cavity (0.5%) and 8 in pts with central tumors (1.1%). Conclusions: ARIES has the largest series of independently reviewed BL scans from advanced NSCLC pts, providing an opportunity to correlate radiographic factors with outcomes in BV treated pts. Although limited by small numbers, the data suggest that cavitation is not predictive of SPH. Correlation of BL radiographic characteristics with outcomes and risk factor analysis will be presented. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Genentech, Infinity Pharma AstraZeneca, BIPI, Genentech, Merck Infinity Pharma, Roche Genentech
Disordered intermixing at the platinum:silicon interface demonstrated by high-resolution cross-sectional transmission electron microscopy, Auger electron spectroscopy, and MeV ion channeling (1988)

The metallurgical interaction at the interface between single-crystal silicon substrates and thin films of elemental platinum has been examined using the complementary techniques of high-resolution cross-sectional transmission electron microscopy (HRXTEM), Auger sputter profiling, and MeV ion channeling. We identify the existence of a 30-Å-thick layer of intermixed platinum and silicon which forms at the metal-silicide interface when 50 Å of Pt is electron beam evaporated onto room-temperature Si. The interfacial layer is evident in the HRXTEM as a uniform band of dark and noncrystalline contrast. In Auger sputter profiling, the evolution of the Si LVV line shape indicates the presence of a platinum silicide region adjacent to the film/Si interface but not at the surface of the Pt film. MeV ion channeling reveals that ∼1.5×1016 Si atoms/cm2 are displaced from their substrate lattice sites upon Pt deposition. In addition, the HRXTEM reveals islands of unreacted Pt and occasional grains of Pt2Si on top of the intermixed layer of Pt and Si.
Selective counting of krypton atoms using resonance ionization spectroscopy (1984)

Resonance ionization spectroscopy (RIS) was used to count 1000 individual 81Kr atoms. In the method, lasers for RIS are used to obtain atomic species (Z) selectivity and a small quadrupole mass spectrometer provides isotopic (A) selectivity. After Z and A selection the krypton ions were counted as they were implanted into a target. Basically, the method works for any isotope whether stable or unstable. However, the detection limit may depend on the isotope because of outgassing of stable atoms from the enclosure walls. For 81Kr, we show that fewer than 1000 atoms can be counted with good accuracy.
Effects of Pharmacopuncture and <i>Danggwisu</i>-powder for Lateral Malleolus Avulsion Fracture: a Case Report (2015)

Objectives : The purpose of this study is to report the clinical effect of Korean medical treatment, specifically Homnis Placenta pharmacopuncture, bee venom injection and Danggwisupowder, on a patient suffering from a lateral malleolus avulsion fracture. Methods : A 63-year-old female patient suffering from right ankle pain due to lateral malleolus avulsion fracture was treated with Homnis Placenta pharmacopuncture, bee venom injection, and herbal medicine(Danggwisu-powder). from May 20th to June 16 th of 2015. The change in patientcondition was measured with the American Orthopedic Foot and Ankle Society Ankle-Hindfoot Scale, the verbal numerical rating scale, and via the ankle's range of motion. Results : After treatment, all obtained results showed improvement. The American Orthopedic Foot and Ankle Society Ankle-Hindfoot Scale increased from 18 to 71, the verbal numerical rating scale changed from 8 to 3, and the ankle's range of motion improved. Conclusions : This study suggests that Korean medical care focused on Homnis Placenta pharmacopuncture, bee venom injection and Danggwisu-powder can be effective to treat lateral malleolus avulsion fracture.
Study of the contact electrification of polymers using contact and separation current (1992)

An instrument was developed that measures the current resulting from surface charge rearrangement during individual contact and separation events involving an insulating sample and a metal probe. It is shown that the values of peak current measured can be used to determine the position of the insulator in a triboelectric series. A modified field mill instrument was used to verify the accuracy of the triboelectric series determined using the contact-separation technique on a set of polymer films. Results agree with published triboelectric series in all cases for which there was agreement among the published series. All measurements were made in a controlled environment on samples which had been stored in a nitrogen atmosphere. The instrument offers the advantages of short measurement time and the ability to make nondestructive measurements on samples of arbitrary thickness including films which are <10 nm thick. Measurements can be made on either conducting or insulating samples.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis of New Metal-Free Diazonium Salts and Their Applications to Microlithography (1989)

New metal-free diazonium salts have been synthesized and applied to microlithography as photobleachable dyes for a contrast enhancing layer (CEL), negative working photoactive compounds, and photoacid generators. 4-N, N-dimethylaminobenzenediazonium trifluoromethanesulfonate (D1) is the most suitable photobleachable dye. Upon i-line (365nm) exposure, 0.4-μm line-and-space patterns were obtained using a positive resist in conjunction with the D1-CEL. D1 also shows good properties as a negative working sensitizer for a two-layer resist system formed by means of a "doping" process, in which the diazonium salt is distributed in the top and bottom layers. 4-Methoxybenzenediazonium trifluoromethanesulfonate can be used as a photoacid generator for acid catalyzed cross-linking. Submicron resolution can be achieved with high sensitivity.
ChemInform Abstract: THE DEHYDROGENATION OF THE ALLEGED HEXAHYDRO‐1,2,4‐TRIAZINE‐3,6‐DIONE (1980)

Abstract Bei der Dehydrierung des Amino‐hydantoins (II) mit Brom oder Hypochlorit entsteht das Diazen (III).
On the Vibration of a Point-Supported Linear Distributed System (1988)

The vibration of a constrained dynamical system, consisting of an Euler-Bernoulli beam with homogeneous boundary conditions, supported in its interior by arbitrarily located pin supports and translational and torsional linear springs, is studied. A generalized differential equation is obtained by the method of separation of variables and is solved in terms of the Green’s function and its derivatives of the unconstrained beam. System natural frequencies and modes are obtained, and the orthogonality relation for the natural modes is derived. A general solution for the forced response is given. Finally, two pertinent problems from the literature are examined, and results obtained are compared with those of a small, dedicated finite element formulation to assess the relative accuracy and efficiency of each.
Application of the Boundary Layer Data System on a Laminar Flow Swept Wing Model In Flight (2010)

Two versions of a small, self-contained device developed specifically to measure boundary layer characteristics – collectively referred to as the Boundary Layer Data System – were applied in a flight test of a 30-degree laminar flow swept wing test article. The devices were used to provide local boundary layer measurements in conjunction with surface pressure and infrared image measurements for an Air Force Research Laboratorysponsored test of Northrop Grumman’s SensorCraft wing design. The model was carried aloft by Scaled Composites’ White Knight aircraft. The flight altitudes of over 40,000 ft, Mach numbers above 0.5, and local dynamic pressures up to 150 psf are the highest values yet for application of the devices. Two different configurations of the Boundary Layer Data System were flown: a device with a stage to position a traversing pressure probe, and a version of the device with a stationary surface Preston tube. The devices weigh less than a pound and are completely self-contained, meaning that they have their own internal power and memory. The devices attach to the test surface with double-sided structural adhesive tape and thus require no mechanical penetration of the test surface, making them a flexible tool for flight testing. This paper describes the devices, their use on the flight test, and presents some sample results.
Layered MIMO scheme with antenna grouping (2004)

In this paper we extend our previously proposed layered turbo coded multiple-input multiple-output (MIMO) scheme by introducing new techniques to improve the design of the transmitter and the receiver. These MIMO systems feature two antenna per layer with random antenna grouping, which reduces interference between layers. And multidimensional set partition is applied to encoder design to improve the coding gain. Based on these design techniques, the receiver only uses simple parallel interference cancellation (PIC) with spatial matched filtering (SMF) to separate the signals from different layers. It is shown that the performance of the proposed scheme is within 2 dB of outage capacity and is similar or better than other proposed MIMO schemes using more sophisticated interference suppression techniques.