gebhart/patrepeval huggingface dataset:
Carotid Plaque and Candidate Genes Related to Inflammation and Endothelial Function in Hispanics From Northern Manhattan (2011)

We report novel associations between variations in 10 genes involved in inflammation and endothelial function and carotid plaque phenotypes in a Dominican sample, with replication for 5 genes in an independent Dominican sample.
Advances in dissolution understanding and their implications for cement hydration (2017)

Recent advances in bridging kinetics and thermodynamics of mineral dissolution have opened new horizons in our understanding of the role of dissolution in cement hydration. Indeed most hydration kinetic regimes of alite can be rationally envisioned from a dissolution perspective. This short note reviews some key findings on dissolution mechanisms and their implication for cementitious systems.
Imaging application tools for extremely low-k1 ArF immersion lithography (2013)

The k1 factor continues to be driven downward in ArF immersion lithography, even below its limit from optical theory, using various lithographic techniques such as combination of Source and Mask Optimization (SMO) and multiple patterning. Such a low k1 factor tends to lead to extremely high sensitivity tp imaging parameters such as aberrations, distortion, illumination pupilgram shape, dose, focus, etc. Therefore, fast, precise and stable settings of these parameters are crucial to make such hyper low k1 lithography practical. We introduce various kinds of imaging application tools and technique, which we have been developing, to support the imaging parameter settings and control. The application tools cover illumination pupilgram adjustment for freeform illumination, automatic aberration control, and thermal aberration parameter settings.
Central venous pressure during the post-anhepatic phase is not associated with early postoperative outcomes following orthotopic liver transplantation. (2010)

Maintaining a lower central venous pressure during the post-anhepatic phase during orthotopic liver transplantation is not associated with any benefit in terms of immediate postoperative allograft function, graft survival or patient survival.
Analysis of rapid manufacturing—using layer manufacturing processes for production (2003)

Rapid prototyping (RP) technologies that have emerged over the last 15 years are all based on the principle of creating three-dimensional geometries directly from computer aided design (CAD) by stacking two-dimensional profiles on top of each other. To date most RP parts are used for prototyping or tooling purposes; however, in future the majority may be produced as end-use products. The term ‘rapid manufacturing’ in this context uses RP technologies as processes for the production of end-use products. This paper reports findings from a cost analysis that was performed to compare a traditional manufacturing route (injection moulding) with layer manufacturing processes (stereolithography, fused deposition modelling and laser sintering) in terms of the unit cost for parts made in various quantities. The results show that, for some geometries, it is more economical to use layer manufacturing methods than it is to use traditional approaches for production in the thousands.
Syntheses and 1H-NMR studies of methyl 4,6-di-O-glucopyranosyl-.BETA.-D-glucopyranosides chirally deuterated at the (1.RAR.6)-linkage moiety. (1988)

Four stereoisomers of methyl 4, 6-di-O-D-glucopyranosyl-β-D-glucopyranosides, in which the H-6proS proton at the (1→6)-linkage moiety was selectively replaced by a deuterium (2H), were synthesized through the photobromination of 1, 6-anhydro-per-O-acetyl-β-D-maltopyranose and β-D-glucose, with subsequent deuteride reduction of the brominated products (C-6exo bromides) by tri-n-butyltin deuteride. The chirally deuterated sugars enabled us to differentiate the H-6proR and H-6proS signals at the (1→6)-linkage moiety and, thereby, to clarify the conformational distributions about the C5-C6 bonds.
Practical probabilistic programming with monads (2015)

The machine learning community has recently shown a lot of interest in practical probabilistic programming systems that target the problem of Bayesian inference. Such systems come in different forms, but they all express probabilistic models as computational processes using syntax resembling programming languages. In the functional programming community monads are known to offer a convenient and elegant abstraction for programming with probability distributions, but their use is often limited to very simple inference problems. We show that it is possible to use the monad abstraction to construct probabilistic models for machine learning, while still offering good performance of inference in challenging models. We use a GADT as an underlying representation of a probability distribution and apply Sequential Monte Carlo-based methods to achieve efficient inference. We define a formal semantics via measure theory. We demonstrate a clean and elegant implementation that achieves performance comparable with Anglican, a state-of-the-art probabilistic programming system.
An unusual presentation of Guillain-Barre syndrome associated with monospecific anti-GD1b antibodies (2010)

status: Published
Dermatology in France (1992)

France is considered to be one of the birthplaces of dermatology. The first and fourth World Congresses were held at Hôpital Saint-Louis, Paris, in 1889 and 1900. They took place in the wax museum of Hôpital Saint-Louis, which houses a unique collection of "moulages" (wax models) of skin diseases from France and other parts of the world. Today, dermatology remains a very active and well-recognized speciality, with approximately 2300 practicing dermatologists and 35 university clinical departments. Scientific communications in dermatology are under the responsibility of many active scientific societies. The most prominent,<i>La Société Française de Dermatologie</i>, is responsible for publishing<i>Les Annales de Dermatologie</i>and for the organization of several national meetings. The most important national meeting is<i>Les Journées Dermatologiques de Paris</i>, which is well known for the quality of its clinical presentations. The first<i>Journées Dermatologiques de Paris</i>was organized in 1961. Today, more than 2500 participants
Suspended Spot‐Size Converters for Scalable Single‐Photon Devices (2019)

Abstract The realization of a highly efficient optical spot‐size converter for the end‐face coupling of single photons from GaAs‐based nanophotonic waveguides with embedded quantum dots is reported. The converter is realized using an inverted taper and an epoxy polymer overlay providing a 1.3 µm output mode field diameter. The collection of single photons from a quantum dot into a lensed fiber with a rate of 5.84 ± 0.01 MHz is demonstrated and a chip‐to‐fiber coupling efficiency of is estimated. The stability and compatibility with cryogenic temperatures make the epoxy waveguides a promising material to realize efficient and scalable interconnects between heterogeneous quantum photonic integrated circuits.
Cross-phase modulation in multiple-wavelength adiabatic soliton repeaterless transmission (2002)

We demonstrate four-channel, wavelength-division-multiplexed transmission over 235 km using adiabatic soliton propagation. Adiabatic evolution of the spectrum allows precise characterization of soliton cross-phase modulation effects.
Howells, Elinor Mead, [1881] November 25 (1881)

learned that your husband was 'doing as well as could be expected'; includes typed transcription
Regional Neonatal Associates for cooperative study of platelet-activating factor (PAF). Summary report (1992)

Lipid inflammatory mediators are thought to play an important role in the pathogenesis of the respiratory distress syndrome, including neonatal lung injury and bronchopulmonary dysplasia (BPD). One such mediator is platelet-activating factor (PAF), a potent bioactive phospholipid that induces adverse airway, vascular, and microcirculatory responses. To study the role of PAF in neonatal lung disease, we used an {sup 125}I-radioimmunoassay to measure PAF in whole blood and tracheal lavage in very low birthweight infants at 1, 3, 5, 9, 21 and 28 days after birth. PAF was found in the pulmonary lavagate and blood of ventilated infants as early as one day after birth. Lavagate levels of PAF increased with acute injury (pneumothorax, pneumonia) but were not associated with BPD. Our results indicate PAF could be associated with the pathogenesis of BPD. We suggest that as a consequence of the pathophysiologic processes associated with BPD, PAF is released by pulmonary cells. Our preliminary data indicate that low birthweight infants also have lower PAF acetylhydrolase levels in cord blood and tracheal lavagate as compared to adults. Therefore, it is possible the increased levels of PAF in the blood of low birthweight infants might be due to persistent transient increases in PAF alveolar levels coupled with lower blood acetylhydrolase activities and could be important in the development of symptoms associated with BPD. Future plans for this project call for completing the enzymatic study of acetylhydrolase activity in pulmonary lavage of the BPD infants.
New resources for genetic studies in <i>Populus nigra</i>: genome‐wide <scp>SNP</scp> discovery and development of a 12k Infinium array (2016)

Whole genome resequencing of 51 Populus nigra (L.) individuals from across Western Europe was performed using Illumina platforms. A total number of 1 878 727 SNPs distributed along the P. nigra reference sequence were identified. The SNP calling accuracy was validated with Sanger sequencing. SNPs were selected within 14 previously identified QTL regions, 2916 expressional candidate genes related to rust resistance, wood properties, water-use efficiency and bud phenology and 1732 genes randomly spread across the genome. Over 10 000 SNPs were selected for the construction of a 12k Infinium Bead-Chip array dedicated to association mapping. The SNP genotyping assay was performed with 888 P. nigra individuals. The genotyping success rate was 91%. Our high success rate was due to the discovery panel design and the stringent parameters applied for SNP calling and selection. In the same set of P. nigra genotypes, linkage disequilibrium throughout the genome decayed on average within 5-7 kb to half of its maximum value. As an application test, ADMIXTURE analysis was performed with a selection of 600 SNPs spread throughout the genome and 706 individuals collected along 12 river basins. The admixture pattern was consistent with genetic diversity revealed by neutral markers and the geographical distribution of the populations. These newly developed SNP resources and genotyping array provide a valuable tool for population genetic studies and identification of QTLs through natural-population based genetic association studies in P. nigra.
Cell-lineage regulated myogenesis for dystrophin replacement: a novel therapeutic approach for treatment of muscular dystrophy (2008)

Duchenne muscular dystrophy (DMD) is characterized in skeletal muscle by cycles of myofiber necrosis and regeneration leading to loss of muscle fibers and replacement with fibrotic connective and adipose tissue. The ongoing activation and recruitment of muscle satellite cells for myofiber regeneration results in loss of regenerative capacity in part due to proliferative senescence. We explored a method whereby new myoblasts could be generated in dystrophic muscles by transplantation of primary fibroblasts engineered to express a micro-dystrophin/enhanced green fluorescent protein (muDys/eGFP) fusion gene together with a tamoxifen-inducible form of the myogenic regulator MyoD [MyoD-ER(T)]. Fibroblasts isolated from mdx(4cv) mice, a mouse model for DMD, were efficiently transduced with lentiviral vectors expressing muDys/eGFP and MyoD-ER(T) and underwent myogenic conversion when exposed to tamoxifen. These cells could also be induced to differentiate into muDys/eGFP-expressing myocytes and myotubes. Transplantation of transduced mdx(4cv) fibroblasts into mdx(4cv) muscles enabled tamoxifen-dependent regeneration of myofibers that express muDys. This lineage control method therefore allows replenishment of myogenic stem cells using autologous fibroblasts carrying an exogenous dystrophin gene. This strategy carries several potential advantages over conventional myoblast transplantation methods including: (i) the relative simplicity of culturing fibroblasts compared with myoblasts, (ii) a readily available cell source and ease of expansion and (iii) the ability to induce MyoD gene expression in vivo via administration of a medication. Our study provides a proof of concept for a novel gene/stem cell therapy technique and opens another potential therapeutic approach for degenerative muscle disorders.
Phonon propagation dynamics in band-engineered one-dimensional phononic crystal waveguides (2015)

The phonon propagation dynamics in a phononic crystal waveguide, realized via a suspended one-dimensional membrane array with periodic air holes, is investigated as function of its geometry. The bandstructure of the phononic crystal can be engineered by modifying the characteristics of the phonon standing waves in the waveguide by varying the waveguide width and the pitch of the air holes. This enables the phonon transmission bands, the bandgaps, the velocity and the nonlinear dispersion in the phononic crystal to be controlled. Indeed the engineered bandstructure can also be tuned to sustain multiple phonon modes in a given branch which whilst being spectrally degenerate can be temporally resolved via their differing group velocities. This systematic study reveals the key geometric parameters that enable the phonon transport in phononic crystal waveguides to be fully controlled.
Impact Testing and Simulation of Composite Airframe Structures (2014)

Dynamic tests were performed at NASA Langley Research Center on composite airframe structural components of increasing complexity to evaluate their energy absorption behavior when subjected to impact loading. A second objective was to assess the capabilities of predicting the dynamic response of composite airframe structures, including damage initiation and progression, using a state-of-the-art nonlinear, explicit transient dynamic finite element code, LS-DYNA. The test specimens were extracted from a previously tested composite prototype fuselage section developed and manufactured by Sikorsky Aircraft Corporation under the US Army's Survivable Affordable Repairable Airframe Program (SARAP). Laminate characterization testing was conducted in tension and compression. In addition, dynamic impact tests were performed on several components, including I-beams, T-sections, and cruciform sections. Finally, tests were conducted on two full-scale components including a subfloor section and a framed fuselage section. These tests included a modal vibration and longitudinal impact test of the subfloor section and a quasi-static, modal vibration, and vertical drop test of the framed fuselage section. Most of the test articles were manufactured of graphite unidirectional tape composite with a thermoplastic resin system. However, the framed fuselage section was constructed primarily of a plain weave graphite fabric material with a thermoset resin system. Test data were collected from instrumentation such as accelerometers and strain gages and from full-field photogrammetry.
Role of Microstructure in Susceptibility of X70 Pipeline Steel to Hydrogen Embrittlement (2010)

In order to investigate the susceptibility of steels to hydrogen embrittlement as a function of their microstructure X70 steel was chosen in different conditions: normalized transfer bar, as-received hot rolled strip and heat affected zone (HAZ). Notched and fatigue pre-cracked samples were subjected to electrochemical hydrogen charging to achieve 2 ppm hydrogen content. Three point bend tests were conducted on as-received and hydrogen charged samples. The results showed that HAZ samples are more susceptible to hydrogen embrittlement than the others. This was supported by fracture surface observations.
Zařízení pro automatické prohřívání tlakových nádob zejména parních turbín a parovodů (1972)

Předmětem vynalezu je zařizeni pro automaticke prohřivani tlakových parnich turbin a parovodů.Prohřivani lze v zasadě provadět dvojim způsobem statickým zvysovanim tlaku pary v nadobě přicemž para nadobou neproteka a nadoba se ohřiva až na teplotu syte pary při danem tlaku nebo průtokem přehřate pary. Podstata vzalezu spociva v tom, že je vytvořeno jako kombinace regulatoru tlaku a anologoveho výpoctoveho zařizeni u ktereho regulator tlaku je řizen ohvanou soustavou.
Characteristics of on-body 802.15.4 networks (2006)

One would expect a body-area network to have consistently good connectivity, given the relatively short distances involved. However, early experimental results suggest otherwise. This poster examines the characteristics of the links in an on-body IEEE 802.15.4 network and the factors that influence link performance. We demonstrate that node location, as well as body position, significantly affects connectivity. For example, connectivity in the sitting position tends to be much worse than standing. We will present a comprehensive evaluation including various combinations of changes in node orientation, node placement, body position, and environmental factors. Preliminary results clearly demonstrate the need for researching different radios, topologies and protocol design to make body area networks viable.
Light-by-Light Management via Defect Mode Excitation in a Resonant Photonic Crystal (2005)

We consider the interaction within a bunch of coherent optical pulses in a one dimensional, resonant photonic crystal which includes a defect produced by a coherent pump. Using numerical methods, the defect is shown to provide a selective reversible trap for a gap soliton mediated by the long-range coupling. This opens up new opportunities for signal transmission control and light localization
Holes in the Jackson Hole Approach to Health Care Reform (1993)

MANAGED competition is synonymous with market-oriented health care reform. Those who coined the phrase, the Jackson Hole Group,1have been identified, incorrectly, by theNew York Times2as the brain trust for the Clinton administration's reform proposal. Many medical industry groups have participated in developing the Jackson Hole version of managed competition, including major insurance companies, the American Medical Association, the Pharmaceutical Manufacturers Association, and large health maintenance organizations (HMOs). About the only significant interest groups that have not expressed support for the concept are those representing consumers. In this article, we critically assess the Jackson Hole Group's proposal to control health spending and provide access to quality health care. Boiled down to its fundamentals, the Jackson Hole approach to managed competition requires three major changes in the US health insurance system. First, regional health insurance purchasing cooperatives (HIPCs) are formed to manage the marketplace for health care
Melghirimyces algeriensis gen. nov., sp. nov., a member of the family Thermoactinomycetaceae , isolated from a salt lake (2011)

A novel filamentous bacterium, designated NariEX(T), was isolated from soil collected from Chott Melghir salt lake, which is located in the south-east of Algeria. The strain was an aerobic, halotolerant, thermotolerant, Gram-positive bacterium that was able to grow in NaCl concentrations up to 21% (w/v), at 37-60 °C and at pH 5.0-9.5. The major fatty acids were iso- and anteiso-C(15:0). The DNA G+C content was 47.3 mol%. The major menaquinone was MK-7, but MK-6 and MK-8 were also present. The polar lipid profile consisted of phosphatidylglycerol, diphosphatidylglycerol, phosphatidylethanolamine and phosphatidylmonomethylethanolamine (methyl-PE). Results of molecular and phenotypic analysis led to the description of the strain as a new member of the family Thermoactinomycetaceae. The isolate was distinct from members of recognized genera of this family by morphological, biochemical and chemotaxonomic characteristics. Strain NariEX(T) showed 16S rRNA gene sequence similarities of 95.38 and 94.28% with the type strains of Desmospora activa and Kroppenstedtia eburnea, respectively, but differed from both type strains in its sugars, polar lipids and in the presence of methyl-PE. On the basis of physiological and phylogenetic data, strain NariEX(T) represents a novel species of a new genus of the family Thermoactinomycetaceae for which the name Melghirimyces algeriensis gen. nov., sp. nov. is proposed. The type strain of Melghirimyces algeriensis, the type species of the genus, is NariEX(T) (=DSM 45474(T)=CCUG 59620(T)).
4 × 40-Gb/s TWDM PON downstream transmission over 42 km and 64-way power split using optical duobinary signals and an APD-based receiver (2015)

We demonstrate downstream transmission of a four-channel 40-Gb/s-per-channel time- and wavelength-division-multiplexed PON over a 42-km, 64-split fiber plant using optical duobinary modulation. At 1550 nm, we obtain a reach of 0-26 km or 16-42 km using two dispersion-precompensation values.
Crystal Structures of Dimethoxyanthracens: A Clue to a Rational Design of Packing Structures of π‐Conjugated Molecules (2020)

We carried out a systematic investigation of packing structures of a series of dimethoxyanthracenes, i. e., 1,4- (1), 1,8- (2), 1,5- (3), 2,6- (4), and 2,7-derivatives (5). The packing structures of the dimethoxyanthracenes are classified into two types, a rubrene-like pitched π-stack (1-3) and a typical herringbone packing (4 and 5), which evidently show that the position of methoxy groups is crucial to determine the packing structure of dimethoxyanthracenes. Effects of the substitution position on intermolecular interactions are analyzed by the noncovalent intermolecular interaction (NCI) method, Hirshfeld surface analysis, and symmetry-adapted perturbation theory (SAPT) method, thus clarifying active roles of the methoxy groups in the formation of rubrene-like pitched π-stack. The present results shed light on a molecular design strategy to realize the rubrene-like pitched π-stack in the solid state, which had been regarded as a packing structure limited for rubrene and its closely related derivatives.
Effects of HCV Treatment on Cytokine Expression During HCV/HIV Coinfection (2006)

There is growing evidence that cytokine expression is linked to hepatitis C virus (HCV) pathogenesis and treatment response rates among HCV-monoinfected persons. However, because of the profound effects of human immunodeficiency virus (HIV) coinfection on HCV, it is not clear if these observations are also true for HCV/HIV-coinfected individuals. Serum expression of the proinflammatory cytokines interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) and the fibrogenic cytokine transforming growth factor-beta1 (TGF-beta1) were measured in HCV/HIV-coinfected persons at baseline and at week 24 of HCV therapy. Higher levels of IL-8 and TGF-beta were demonstrated among nonwhite subjects at baseline. Increases in TNF-alpha and IL-8 expression were found at week 24 of HCV therapy, suggesting that enhanced proinflammatory cytokine production may occur during HCV treatment. However, cytokine levels were not predictive of HCV virologic, biochemical, or histologic response. Although previous studies conducted among HCV-monoinfected individuals have suggested that cytokine levels could predict the virologic response to therapy, no such associations were observed among HCV/HIV-coinfected persons, suggesting that they may respond differently to treatment than do their HCV-monoinfected counterparts.