gebhart/patrepeval huggingface dataset:
The Osmotic Activation of Transporter ProP Is Tuned by Both Its C-terminal Coiled-coil and Osmotically Induced Changes in Phospholipid Composition (2005)

Transporter ProP of Escherichia coli (ProPEc) senses extracellular osmolality and mediates osmoprotectant uptake when it is rising or high. A replica of the ProPEc C terminus (Asp468-Arg497) forms an intermolecular alpha-helical coiled-coil. This structure is implicated in the osmoregulation of intact ProPEc, in vivo. Like that from Corynebacterium glutamicum (ProPCg), the ProP orthologue from Agrobacterium tumefaciens (ProPAt) sensed and responded to extracellular osmolality after expression in E. coli. The osmotic activation profiles of all three orthologues depended on the osmolality of the bacterial growth medium, the osmolality required for activation rising as the growth osmolality approached 0.7 mol/kg. Thus, each could undergo osmotic adaptation. The proportion of cardiolipin in a polar lipid extract from E. coli increased with extracellular osmolality so that the osmolality activating ProPEc was a direct function of membrane cardiolipin content. Group A ProP orthologues (ProPEc, ProPAt) share the C-terminal coiled-coil domain and were activated at low osmolalities. Like variant ProPEc-R488I, in which the C-terminal coiled-coil is disrupted, ProPEc derivatives that lack the coiled-coil and Group B orthologue ProPCg required a higher osmolality to activate. The amplitude of ProPEc activation was reduced 10-fold in its deletion derivatives. The coiled-coil structure is not essential for osmotic activation of ProP per se. However, it tunes Group A orthologues to osmoregulate over a low osmolality range. Coiled-coil lesions may impair both coiled-coil formation and interaction of ProPEc with amplifier protein ProQ. Cardiolipin may contribute to ProP adaptation by altering bulk membrane properties or by acting as a ProP ligand.
Development and application of insulation coordination program for UHVDC converter stations (2008)

This paper offers a program to improve the efficiency and accuracy of insulation coordination calculation for UHVDC converter stations. The program is based on the VBA of Excel. It has the functions of selecting arresters scheme, modifying and saving the parameters, inquiring about and adding the arrester characteristics curves and so on. It is applied to calculate the insulation coordination levels in the Xiangjiaba-Shanghai UHVDC system. The program is proved to be accurate, fast, and convenient, and can be applied well for UHVDC converter stations.
AFM Characterization of the Nanoparticles Arrangement by Electrophoretic Deposition (2012)

In this study, coatings with irregular nanotopography prepared by electrophoretic deposition (EPD) in electro-polished surfaces are characterized. Films are composed by Yttria Stabilized Zirconia (YSZ) particles, 5-8 nm in size and spherical morphology, synthesized under hydrothermal conditions and re-dispersed in the post reaction medium. Growth behaviour of coatings with time, including array morphology, aggregation origin and activity, are explored by means of atomic force microscopy (AFM) and its different measurement modes. Arrangement of electrically driven particles at the nanoscale can be assessed through the topographic description of films prepared with increasing deposition times. Moreover, topography can be associated to the electrokinetic behaviour of particles and agglomeration degree of the suspension. The evaluation of particle junctions and then the quality of particle cohesion within the film can also be discerned by AFM characterization.
SEO - Suchmaschinenoptimierung (2013)

SEO (Suchmaschinenoptimierung) steigert Besucherzahlen auf der eigenen Website, verbessert das Ranking und sorgt auf diese Weise auch für mehr Umsatz. Die Suchmaschinenoptimierung wird in erster Linie über Keywords (Schlagwörter) gesteuert. Wir zeigen, wie das geht.
High-Performance Liquid Chromatographic Determination of 12 Antiarrhythmic Drugs in Plasma Using Solid-Phase Column Extraction (1991)

Monitoring of plasma concentrations of antiarrhythmic drugs may assist in individualizing dosage regimens and in assessing patient compliance. A rapid high-performance liquid chromatographic assay using solid-phase column extraction was developed for the following antiarrhythmic drugs: amiodarone, aprindine, disopyramide, flecainide, lidocaine, lorcainide, mexiletine, procainamide, propafenone, sotalol, tocainide, and verapamil. As most of the antiarrhythmic drugs are basic compounds, good adsorption on the extraction columns was obtained by alkalinization; aprindine, however, was applied at neutral pH and amiodarone at pH 3.5. After washing with water, the compounds were eluted with methanol, but amiodarone was eluted with a mixture of acetonitrile and acetate buffer at pH 5 (8/2, vol/vol). Most of the eluates were evaporated to dryness and reconstituted in the mobile phase; for amiodarone, disopyramide, and tocainide, direct injection onto the column was performed. Separation was done on a Spherisorb hexyl 5 mu column (150 x 4.6 mm I.D.) and the mobile phases consisted of mixtures of acetonitrile or methanol with phosphate or acetate buffers at different pH values. Detection was performed by UV or fluorescence detector. Coefficients of variation were lower than 10% with good recovery and linearity in the expected therapeutic ranges.
Introduction to Hardware Abstraction Layers for SoC (2003)

In this paper, we explain hardware abstraction layer (HAL) and related issues in the context of SoC design. First, we give a HAL definition and examples of HAL function. HAL gives an abstraction of HW architecture to upper layer software (SW). It hides the implementation details of HW architecture, such as processor, memory management unit (MMU), cache, memory, DMA controller, timer, interrupt controller, bus/bus bridge/network interface, I/O devices, etc. HAL has been used in the conventional area of operating system to ease porting OSs on different boards. In the context of SoC design, HAL keeps still the original role of enabling the portability of upper layer SW. However, in SoC design, the portability impacts on the design productivity in two ways: SW reuse and concurrent HW and SW design. As in the case of HW interface standards, e.g. VCI, OCP-IP, etc., the HAL API needs also a standard. However, contrary to the case of HW interface, the standard of HAL API needs to be generic not only to support the common functionality of HAL, but also to support new HW architectures in application-specific SoC design with a guideline for HAL API extension. We present also three important issues of HAL for SoC design: HAL modelling, application-specific and automatic HAL design.1
Thyroid Hormone and Male Gonadal Function* (1995)

WHILE the effects of hyper- and hypothyroidism1 in female gonadal functions are well established (1, 2), controversy exists regarding the impact of thyroid diseases on male reproduction. This is due to various reasons: 1) the apparent clinical irrelevance of signs and symptoms related to male gonadal function, compared with the systemic effects of hyper- and hypothyroidism; 2) the paucity of well controlled clinical studies, due to the fact that thyroid diseases are more common in females than in males; and 3) the demonstration in the 1950s that the adult male gonad of experimental animals is metabolically unresponsive to thyroid hormone (3). Since then, the concept that the testis is unaffected by iodothyronines became widely accepted. For this reason, the potential of thyroid hormone in the modulation of male reproductive functions was not determined for several years. Indeed, in experimental studies on the effect of thyroid hormone in various tissues, the testis has been used as a negative control. This review, in the light of clinical reports and experimental results, will refute this assumption. The body of the review consists of two parts. In the first part the effects of hyper- and hypothyroidism in man on gonadotropin release, sex steroid hormone metabolism, and testicular and sexual functions, both in adulthood and childhood, are discussed. In the second part/animal studies are reviewed. In the rat, which is the most used experimental model, the in vivo and in vitro effects of thyroid hormone on reproductive physiology are discussed. The last section summarizes studies on other animals, from primates to amphibians, and considers the role of the thyroid gland in regulating the seasonal pattern of reproduction.
Opioid use by patients in an orthopedics spine clinic (2005)

This study provides data on the efficacy, toxicity, tolerance, and abuse or addiction behaviors with opioid therapy in a large cohort of patients in an orthopedics spine clinic. The results provide objective data from patients with well-defined spine diagnoses to challenge the position that opioid treatment is inappropriate for chronic nonmalignant pain. This study provides clinical evidence to support and protect physicians treating patients with chronic musculoskeletal diseases, who may be reluctant to prescribe opioids because of possible sanctions from regulatory agencies. More important, it will benefit patients by permitting them to receive these effective, safe medications.
Calculation of heats of formation and dissociation of methyl- and chloro-substituted disilanes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalculation of heats of formation and dissociation of methyl- and chloro-substituted disilanesThomas N. Bell, Kathryn A. Perkins, and Peter G. PerkinsCite this: J. Phys. Chem. 1982, 86, 20, 3922–3925Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://doi.org/10.1021/j100217a008RIGHTS & PERMISSIONSArticle Views74Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (424 KB) Get e-Alerts
Abacterial Pyuria (1945)

of them was opened, but no maggot was found. Blood count: W.B
ANALYZING EMPLOYEE ATTRITION USING DECISION TREE ALGORITHMS (2013)

Employee turnover is a serious concern in knowledge based organizations. When employees leave an organization, theycarry with them invaluable tacit knowledge which is often the source of competitive advantage for the business. In order foran organization to continually have a higher competitive advantage over its competition, it should make it a duty to minimizeemployee attrition. This study identifies employee related attributes that contribute to the prediction of employees’ attritionin organizations. Three hundred and nine (309) complete records of employees of one of the Higher Institutions in Nigeriawho worked in and left the institution between 1978 and 2006 were used for the study. The demographic and job relatedrecords of the employee were the main data which were used to classify the employee into some predefined attrition classes.Waikato Environment for Knowledge Analysis (WEKA) and See5 for Windows were used to generate decision tree modelsand rule-sets. The results of the decision tree models and rule-sets generated were then used for developing a a predictivemodel that was used to predict new cases of employee attrition. A framework for a software tool that can implement therules generated in this study was also proposed.Keywords: Employee Attrition, Decision Tree Analysis, Data Mining
Ricinoleic Acid in Common Vegetable Oils and Oil Seeds (2008)

An original gas chromatography/mass spectrometry method for quantifying trace amounts of ricinoleic acid (12-hydroxy-cis-9-octadecenoic acid) is detailed. Data are presented on trace amounts of ricinoleic acid found in several common vegetable oils and oils extracted from common oil seeds: e.g., ca. 30 ppm in commercial olive oil was the lowest amount; and ca. 2,690 ppm in oil extracted from cottonseeds was the highest amount.
Targeted construction of temperature-sensitive mutations in vaccinia virus by replacing clustered charged residues with alanine. (1994)

The feasibility of using "clustered charge-to-alanine" mutagenesis (replacement by alanine of two or more charged residues clustered in a five- or six-amino acid sequence) to create temperature-sensitive, conditionally lethal mutations in vaccinia virus was examined by creating nine mutations in the vaccinia virus gene G2R. G2R was chosen for this analysis because mutations in this gene confer selectable phenotypes. Specifically, vaccinia viruses that contain a wild-type copy of G2R nare sensitive the effects of the anti-poxvirus drug isatin-beta-thiosemicarbazone (IBT), while mutations in G2R that completely abolish the function of the G2R protein product confer dependence upon IBT for growth. A previously isolated mutant carrying a temperature-sensitive mutation that maps to G2R (Cts56) is resistant to IBT at the permissive temperature and dependent upon IBT at the restrictive temperature. Nine clustered charge-to-alanine mutants were examined. Four of the these mutants (AS1, AS4, AS6, and AS9) display some degree of temperature sensitivity in the function of the G2R gene product. AS1 is temperature sensitive for growth in both a plaque assay and in a one-step growth experiment. AS6 and AS9 form small plaques at the nonpermissive temperature and are temperature sensitive for growth in a one-step growth experiment. AS4 manifests its temperature sensitivity as temperature-dependent IBT resistance. Five of the mutations (AS2, AS3, AS5, AS7, and AS8) appeared to confer phenotypes indistinguishable from that of wild-type vaccinia. These results demonstrate that temperature-sensitive conditionally lethal mutants can be created in vaccinia virus by altering the charge characteristics of essential viral proteins.
A comparison of 3D computer propagation prediction with GSM signal measurements (2002)

This paper presents comparisons between predicted and measured data for a live GSM system. Our propagation prediction software tool is based on 3D-ray tracing, and considers wave interactions, such as free space, reflection, diffraction, and scattering. The underlying principles used in the prediction tool are geometric theory of diffraction (GTD), with its uniform theory of diffraction (UTD) extension and physical optics to provide signal levels and delay spread information. We have performed GSM measurements in a number of chosen streets in London. The measurement results are analysed in terms of a number of GSM system parameters, which include RXLEV, RXQUAL, and handover characteristics. A 3D representation of the measurement environment was modelled in the software tool using a building database to verify the computer prediction and to show that 3D prediction is viable for small urban cells with excellent accuracy and speed.
Das System des Bedeckungssterns TT Lyrae (1968)

Abstract For this typical Algol system with the period 5.24 days, complete light curves in two colours have been derived from 160 photoelectric measurements in B and 173 in V. The primary minimum has been found to be total and asymmetric. To get a satisfactory photometric solution it was necessary to allow for the dissimilarity of the components. For the coefficients of limbdarkening of the Ao‐component the values x = 0.35 · 0.11 (B) and 0.44 · 0.10 (V) have been deduced.
A Neutron Spectrometer Using Organic Scintillators. (1971)

Organic scintillation detectors are useful for neutron spectroscopy because pulses induced by gamma rays and those induced by neutrons can be distinguished by electronic means. Computer analysis can be used to obtain the energy spectrum of the neutrons from the measured recoil-proton pulse-height distribution. The report describes a practical neutron spectrometer with improved electronic circuitry for pulseshape discrimination. A detailed study of the interaction of neutrons with the scintillator is presented in relation to pulse-height analysis. A computer program that uses a straightforward method of pulse-height analysis is given in FORTRAN with suggestions for adaptation for use on a small computer. Spectrometer applications are presented for measuring neutron spectra of monoenergetic neutrons, radioactive neutron sources, scattered neutrons and neutrons from a photonuclear reaction and also for detection of fission neutrons. (Author)
Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering (2015)

Dynamic ensembles of macromolecules mediate essential processes in biology. Understanding the mechanisms driving the function and molecular interactions of 'unstructured' and flexible molecules requires alternative approaches to those traditionally employed in structural biology. Small-angle X-ray scattering (SAXS) is an established method for structural characterization of biological macromolecules in solution, and is directly applicable to the study of flexible systems such as intrinsically disordered proteins and multi-domain proteins with unstructured regions. The Ensemble Optimization Method (EOM) [Bernadó et al. (2007 ▶). J. Am. Chem. Soc. 129, 5656-5664] was the first approach introducing the concept of ensemble fitting of the SAXS data from flexible systems. In this approach, a large pool of macromolecules covering the available conformational space is generated and a sub-ensemble of conformers coexisting in solution is selected guided by the fit to the experimental SAXS data. This paper presents a series of new developments and advancements to the method, including significantly enhanced functionality and also quantitative metrics for the characterization of the results. Building on the original concept of ensemble optimization, the algorithms for pool generation have been redesigned to allow for the construction of partially or completely symmetric oligomeric models, and the selection procedure was improved to refine the size of the ensemble. Quantitative measures of the flexibility of the system studied, based on the characteristic integral parameters of the selected ensemble, are introduced. These improvements are implemented in the new EOM version 2.0, and the capabilities as well as inherent limitations of the ensemble approach in SAXS, and of EOM 2.0 in particular, are discussed.
Accurate Alignment of Double-Sided Manuscripts for Bleed-Through Removal (2008)

Double-sided manuscripts are often degraded by bleed-through interference. Such degradation must be corrected to facilitate human perception and machine recognition. Most approaches to bleed-through removal rely on perfect alignment between the recto and verso images of a document. This paper presents a two-stage hierarchical alignment technique that can efficiently and accurately align the two sides of a document. Our approach first coarsely aligns the two images using a pair of anchors extracted from the recto and verso images respectively. The coarsely aligned images are then precisely aligned using block matching and radial basis function (RBF) based interpolation techniques. To evaluate the proposed alignment technique, we build a classification and recovery system to remove bleed-through interference and restore historical manuscripts. The accuracy of our alignment approach is then assessed with the accuracy of bleed-through correction.
Degradation of 2,4,5-trichlorophenol by the lignin-degrading basidiomycete Phanerochaete chrysosporium (1993)

Under secondary metabolic conditions the white rot basidiomycete Phanerochaete chrysosporium rapidly mineralizes 2,4,5-trichlorophenol. The pathway for degradation of 2,4,5-trichlorophenol was elucidated by the characterization of fungal metabolites and oxidation products generated by purified lignin peroxidase (LiP) and manganese peroxidase (MnP). The multistep pathway involves cycles of peroxidase-catalyzed oxidative dechlorination reactions followed by quinone reduction reactions to yield the key intermediate 1,2,4,5-tetrahydroxybenzene, which is presumably ring cleaved. In the first step of the pathway, 2,4,5-trichlorophenol is oxidized to 2,5-dichloro-1,4-benzoquinone by either MnP or Lip. 2,5-Dichloro-1,4-benzoquinone is then reduced to 2,5-dichloro-1,4-hydroquinone. The 2,5-dichloro-1,4-hydroquinone is oxidized by MnP to generate 5-chloro-4-hydroxy-1,2-benzoquinone. The orthoquinone is in turn reduced to 5-chloro-1,2,4-trihydroxybenzene. Finally, the 5-chlorotrihydroxybenzene undergoes another cycle of oxidative dechlorination and reduction reactions to generate 1,2,4,5-tetrahydroxybenzene. The latter is presumably ring cleaved, with subsequent degradation to CO2. In this pathway, the substrate is oxidatively dechlorinated by LiP or MnP in a reaction which produces a quinone. The quinone intermediate is recycled by a reduction reaction to regenerate an intermediate which is again a substrate for peroxidase-catalyzed oxidative dechlorination. This pathway apparently results in the removal of all three chlorine atoms before ring cleavage occurs.
Stevia Rebaudiana Bert. Leaf Extracts as a Multifunctional Source of Natural Antioxidants (2015)

The aim of the presented study was to characterize the content and biological activity of extracts prepared from dried Stevia rebaudiana leaves with potential application in the food or cosmetic industry. Aqueous (A), ethanolic (E) and glycol-aqueous (GA) extracts were analyzed for the content of polyphenols and proteins, showing that the highest amount of phenols (15.50 mg/g) and flavonoids (3.85 mg/g) contained GA. All extracts contained significant amount of protein (69.40-374.67 mg/g). Between analyzed stevia extracts (HPLC) GA contained the highest amount of polyphenols, especially ferulic (5.50 mg/g) and rozmaric (4.95 mg/g) acids derivates. The highest antiradical activity against DPPH• and ABTS•+ was noted for GA and E (IC50 = 0.38 and 0.71 µg flavonoids/mL). The highest ability to chelate Fe2+ was observed for E (IC50 = 2.08 µg flavonoids/mL). Stevia extracts were also analyzed for their cytotoxicity and fibroblast irritation potential in vitro. E and GA were the most cytotoxic and irritating, probably due to the high content of biologically active phytochemicals. On the other hand, a extract was the most tolerable by the cells. To summarize, the presented study evaluated the potential application of A, E and GA stevia extracts as natural source of antioxidants in the food and cosmetic industry.
Power-efficient super class AB OTAs (2004)

A family of low-voltage power-efficient class AB CMOS operational transconductance amplifiers (OTAs) is described. It is based on the combination of adaptive biasing techniques and resistive local common-mode feedback (LCMFB), which provides increased dynamic current boosting and gain-bandwidth product (GBW). The different classes of AB OTA topologies presented result from the combination of various adaptive biasing schemes and LCMFB. A 0.5-/spl mu/m CMOS implementation of three different OTAs shows enhancement factors of slew-rate and GBW up to 280 and 3.6, respectively, for an 80-pF load, compared to a conventional class A OTA with the same quiescent currents and supply voltage. The overhead in area, noise, and static power consumption, is minimal.