gebhart/patrepeval huggingface dataset:
Local Aromatase Expression in Human Prostate Is Altered in Malignancy (2004)

Tissue-specific aromatase production is significant in breast cancer and osteoporosis. Prostatic aromatase expression has been equivocal, and any local actions of estrogens are considered secondary to centrally mediated androgen suppression. We examine local aromatase expression and estrogen biosynthesis in the human prostate. Pure samples of stroma and epithelia from biopsy tissues were isolated by laser capture microdissection. Aromatase protein was detected by Western blot analysis, mRNA by RT-PCR, and enzyme activity by tritiated water assay, whereas promoter use was examined by real-time PCR. In nonmalignant prostate tissues, aromatase mRNA expression was absent from epithelium, but did localize to stroma. Presence of protein was confirmed, and expression was driven by promoter PII. Aromatase was expressed and active in LNCaP, PC3, and DU145 cells in addition to microdissected epithelial tumor cells; benign prostate epithelial cells showed no expression or activity. Promoter use in LNCaP and microdissected tumor cells was via PII, whereas PC3 and DU145 cells used promoter I.4. This study demonstrates local estrogen biosynthesis in prostate-induced aromatase gene expression in malignancy and potential alteration of aromatase promoter use with disease progression. These data provide a basis for continued investigation of local estrogen production and its potential role in prostate disease.
Labs-to-Go Actuation Experiments and Extensions (2015)

Labs-to-Go (LTG) is an inexpensive dynamics and control experiment toolkit suitable for take-home laboratory projects, in-class work, demonstration in lectures, and outreach to K-12 and the general public. The LTG kits consist of a set of smart beam elements, assembly hardware, interface circuitry, a digital signal processing subsystem, and support software. The LTG kits enable take-home labs which reduce the need for our students to commute to campus for labs (40% of UH students commute more than 30 minutes one-way). This paper extends previous work on LTG take-home experiments and introduces the active control experiments. We also describe use of the kits to support other academic disciplines, introductory engineering courses, and outreach.
Elimination of a Reproductive Barrier Facilitates Intergeneric Hybridization of <i>Sorghum bicolor</i> and <i>Saccharum</i> (2010)

Sorghum [ Sorghum bicolor (L.) Moench] and sugarcane ( Saccharum spp.) are now being bred to enhance the quantity and quality of biomass while maintaining or improving biotic and abiotic stress tolerances. Introgression of complementary traits between sorghum and sugarcane may be an important tool for breeders as they work toward these objectives. We show that by using a sorghum line with the iap mutant, intergeneric Sorghum bicolor × Saccharum spp. hybrids can be readily produced. Using Tx3361 as sorghum seed parent, 14,141 seed were produced from 252 sorghum × Saccharum spp. crosses. Seed set frequency in the intergeneric crosses was affected by sugarcane pollinators. The best pollinators had an above average pollen rating and favorable genetic and/or genomic compatibility, implying that breeding and selection of sugarcane pollen parents could further enhance successful hybridization. Avoiding vivipary through premature seed harvest and eliminating a physical barrier by removing the seed coat increased seedling recovery rates from 1.5 to 33%. Using these methods, our programs have grown 1371 sorghum–saccharum intergeneric hybrid plants. Sufficient quantities of seedlings were produced to impose selection criteria with the goal of developing a new intergeneric cultivar with potential to be used for sugar or as a biomass feedstock.
Access to microsystem technology: the CMP services solution (2003)

CMP aims at providing Universities, Research Laboratories and Industries with the possibility to have their integrated circuits projects fabricated for prototyping and low volume production. Presently, users are serviced for CMOS double layer poly/double layer metal (DLP/DLM) 0.8 /spl mu/, DLM/TLM 0.6 /spl mu/, DLP/4LM 0.35 /spl mu/, SLP/6LM 0.18 /spl mu/ and 0.12 /spl mu/, BiCMOS DLP/DLM 0.8 /spl mu/, SiGe BiCMOS DLP/DLM 0.8 /spl mu/ and 5 LM 0.35 /spl mu/, and HEMT GaAs 0.2 /spl mu/. About 40 multi-project runs are offered per year. Micro Electro Mechanical Systems (MEMS) are provided in standard CMP runs in CMOS DLP/DLM 0.8 /spl mu/m and DLM/TLM 0.6 /spl mu/, BiCMOS DLP/DLM 0.8 /spl mu/ and HEMT GaAs 0.2 /spl mu/, using compatible front-side bulk micro-machining. MUMPS process is offered as a surface micro-machining allowing one to integrate MEMS only microstructures. This paper describes the services available, focusing on the most advanced IC processes and on the MEMS processes.
Observations sur quelques<i>dactyloides</i>du genre<i>Saxifraga</i> (1948)

(1948). Observations sur quelques dactyloides du genre Saxifraga. Bulletin de la Société Botanique de France: Vol. 95, 76e Session Extraordinaire (1948) (Gavarnie, Pic de Midi de Bigorre, Neouvielle), pp. 121-124.
A study of group size and communication in an evolving fuzzy-controlled population (2005)

This research effort is an investigation into communication activity in a distributed set of software agents. Agents exist in a predator-prey environment. Movements of prey agents are evolved upon a Mamdani type fuzzy inference system. Probabilistic predation and starvation forces, along with simulated communication activity act upon agents, causing them to cluster. Examined here is the correlation between mean cluster size after the population has sufficiently evolved, versus the average agent communication activity. Communication activity creates a loyalty to remain in a cluster for security rather than to change cluster membership. A mean r/sup 2/ correlation of 0.87 was observed with this system, thus lending credence to our hypothesis.
Nuclear Factor κB2 p52 Protein Has a Role in Antiviral Immunity through IκB Kinase ϵ-dependent Induction of Sp1 Protein and Interleukin 15 (2013)

In this study we describe a previously unreported function for NFκB2, an NFκB family transcription factor, in antiviral immunity. NFκB2 is induced in response to poly(I:C), a mimic of viral dsRNA. Poly(I:C), acting via TLR3, induces p52-dependent transactivation of a reporter gene in a manner that requires the kinase activity of IκB kinase ε (IKKε) and the transactivating potential of RelA/p65. We identify a novel NFκB2 binding site in the promoter of the transcription factor Sp1 that is required for Sp1 gene transcription activated by poly(I:C). We show that Sp1 is required for IL-15 induction by both poly(I:C) and respiratory syncytial virus, a response that also requires NFκB2 and IKKε. Our study identifies NFκB2 as a target for IKKε in antiviral immunity and describes, for the first time, a role for NFκB2 in the regulation of gene expression in response to viral infection.
Some Characteristics of Escherichia coli Strains Isolated from Extraintestinal Infections of Humans (1978)

Escherichia coli strains isolated from extraintestinal infections of humans possess a constellation of phenotypes not usually found in random fecal isolates, enteropathogenic strains, or the laboratory strain E. coli K12. The phenotypes found more commonly in extraintestinal strains include hemolysin production, the biosynthesis of colicin V, and the hemagglutination of human erythrocytes in the presence of D-mannose (HAh). Hemolysin is assumed to be a cytotoxic factor, colicin V is assumed to interfere with host defense mechanisms, and HAh is assumed to play a role in specific tissue adherence. In addition, greater than or equal to 50% of E. coli strains from extraintestinal infections kill allantoically inoculated 13-day-old chick embryos. Some (20%) of the fecal E. coli also kill embryos, but E. coli K12 is innocuous in this virulence model. The plasmids for hemolysin and colicin V production have been transmitted to E. coli K12 derivatives but are not sufficient to convert laboratory strains to a form virulent for the chick embryo.
Closure on “Bibliography on the Application of Induction Generators in Nonconventional Energy Systems” (2004)

For original paper see Bansal et al. (IEEE Trans. Energy Conversion, vol.18, p.433-9, September 2003). The present authors reply to a comment by Mathur (IEEE Trans. Energy Conversion, vol.19, no.3, p.650, September 2004).
A Chiral BINOL‐Zinc Complex as a Novel Catalyst for the Enantioselective Epoxidation of α,β‐Enones. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Kawasaki disease thirty years on (1998)

This year marks the 30th anniversary of the first description of Kawasaki disease. The disease has emerged as an important cause of acquired heart disease in children. The cause of Kawasaki disease remains unknown and this presents many problems in the diagnosis and management of the disease. This paper reviews recent publications on the pathogenesis, diagnosis, and the short- and long-term management of Kawasaki disease.
A GAMMA CELL FOR INFRARED MICROSPECTROSCOPY (1952)

Author Institution: The Children's Cancer Research Foundation, Children's Medical Center and; The Children's Cancer Research Foundation, Resarch Laboratory, Polaroid Corp.
Abstract 4913: A quantitative integrated systems biology approach for modeling cell cycle pathways in normal and tumor cells (2012)

Abstract We have developed a novel biological system for quantitative analysis of biochemical pathways in normal and tumour human cells. The system is based on cells growing in tissue culture media where the concentrations of growth factors, hormones and other components of the media are precisely defined and continuously monitored. Quantitative immunoblotting and luminescence-based reporter assays are then used to measure the cellular concentration of key cell cycle regulatory proteins and their activity in real time in live cells. This technology resulted in accurate measurement of cellular concentration of a number of key cell cycle regulatory proteins such as Cyclins, CDKs and CDK inhibitors during the cell cycle. The data are being utilized in the development of a quantitative integrated systems biology approach to the cell cycle. The approach consists of a comprehensive network of the molecular interaction pathways regulating cell cycle in normal and tumor cells and a model which incorporates the activity of key molecular species in a single dynamical system which can be solved using genetic algorithms designed to match experimental data, both qualitative and quantitative, to the model kinetics. The model could be utilized for the development of new drug targets and would be capable of consistently measuring the effects of existing drugs (either single or in combination) and opens up a methodology for establishing the effectiveness of these drugs with clear implications for cost/benefit assessment. Major impact is expected on clinical research where the model can be a tool in determining intervention strategies in the molecular pathways concerned. Apart from the development of new drug targets the model will be capable of consistently measuring the effects of existing drugs (either single or in combination) and opens up a methodology for establishing the effectiveness of anti-cancer drugs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4913. doi:1538-7445.AM2012-4913
Posterior Shoulder Approach (1985)

A posterior shoulder surgical approach combines the subperiosteal detachment of the deltoid from the scapular spine, described by McWhorter, with a lateral extension to include the lateral deltoid splitting of Codman. The glenohumeral joint is superiorly approached between the supraspinatus and infraspinatus tendons, or inferiorly between the infraspinatus and teres minor tendons. This approach was used in 42 shoulders with rotator cuff tears or posterior instability without complications of infection, failure of deltoid healing, or compromise of suprascapular or axillary nerves. This combined surgical approach provides excellent exposure of the superior and posterior shoulder, which is difficult to obtain by anterior or superior approaches. This approach may be used for repair of rotator cuff tears, posterior instability, and displaced posterior glenoid fractures.
Taylor’s hypothesis convection velocities from mass conservation equation (2011)

We propose to use the continuity equation to calculate convection velocities provided by the Taylor hypothesis for flow structures crossing a measurement plane. This is carried out in Fourier space to identify a velocity associated to each frequency. High-speed PIV experimental data of an axisymmetric mixing layer is used to implement the method. We show that as expected the Taylor hypothesis fails for the lowest frequencies and predicts the convection velocity to be close to the mean velocity for the higher ones. The method is compared to one of the definitions proposed by Del Álamo and Jiménez [J. Fluid Mech. 640, 5 (2009)].
Simple and Facile Synthesis of Phosphonium Salts (1990)

Primary alkyl triphenylphosphonium salts for the Wittig reaction were readily prepared from alcohols and triphenylphosphine hydrobromide.
Structural studies of bacterial transcription initiation (2002)

The specific cellular and biochemical changes that occur in the mammary gland during the non-lactating period have not been fully defined. The 39kilodalton glycoprotein was isolated from goat dry secretions. The protein is glycosylated and immunologically distinct from other milk-associated or serum proteins and from cytoskeletal proteins. The N-terminal sequence and complete cDNA sequence have been determined. It shows 45-50 percent sequence identity with members of the chitinase protein family but lacks chitinase-like binding site. The crystal structure has been determined by molecular replacement method and refined to an R-factor of 0.185 for all the data to 2.9 resolution. The structure shows a fold similar to that of the prototype chitinases but lacks chitinase-like binding site. The shortening of loops makes the structure very compact. The loop 203-213 is particularly noteworthy as it adopts a conformation that is completely different from those observed in the proteins of chitinase family.
Ex-Vivo Perfusion of Surgically Removed Organs (1988)

Surgically removed organs were perfused with oxygenated perfluorochemical blood substitute(FDA-O2). The perfusion was carried out using resected mouse liver. ATP level of perfused liver was remaining normal until 80 min. ATP peak disappeared when perfusion was discontinued, and it reappeared on reperfusion. No significant ischemic changes were demonstrated. Ex-vivo autoradiogram successfully labelled the S phase cells in various organs and various diseases. The absorptive study is also performed. Ex-vivo organ perfusion with FDA-O2 is able to keep the resected human organs viable, and is valuable new method to analyze the function and histogenesis of pathology.
Novel Organopalladium Material Formed on a Sulfur-Terminated GaAs(001) Surface (2002)

By merging the disciplines of organometallic chemistry and surface nanotechnology, we have studied a novel material that combines tetrakistriphenylphosphine palladium (Pd(PPh3)4), a useful organometallic catalyst for producing pharmaceutical substances, with a sulfur-terminated GaAs(001) substrate grown by molecular beam epitaxy. This organopalladium catalyst is reusable in the Heck reaction and Suzuki coupling.
FAST ANALOGUE MULTIPLIERS WITH FIELD-EFFECT TRANSISTORS (1963)

The solution time of analog multipliers using field-effect transistors is investigated. This time is ultimately limited by the charging time of the transistor junction. In typical devices suitable for analog multiplication, the charging time is found to be about 10 to 20 nsec for a multiplication error of < 1%. A four quadrant pulse amplitude multiplier circuit with a solution time equal to the transistor charging time is described. (auth)
Life Assessment of an HP-IP Rotor Under Creep Service Conditions (1990)

A CrMoV high and intermediate-pressure (HP-IP) rotor exhibited in-service cracking in the blade groove walls. Cracks initiated from a notch and propagated under creep conditions to a depth of 0.255 in. (6.5 mm). Since the unit was base loaded, the contribution of cyclic loading (startups and shutdowns) was not significant. The total life of the groove walls is predicted by applying a life prediction approach that accounts for both crack initiation and propagation. Crack initiation life is based on short-term creep tests extrapolated to long times using a time-temperature parameter. Crack propagation time is estimated using a newly developed time-dependent fracture mechanics concept. A parameter Ct is used to express the crack growth rate under creep loading conditions. Pertinent material properties such as creep deformation and creep crack growth rate were obtained by testing the material from the subject rotor. The results obtained by this analysis show that about 50 percent of the estimated life was spent in crack propagation. Predicted service life time compares very favorably with the actual operating life of the rotor.
Use of puppets in a residence for the elderly. (1987)

Creative Arts Coordinator Janice McMurray, on the staff of the Hermitage Methodist Home in Richmond, VA, uses puppets as a communication tool with elderly health-care patients. While puppet variety shows based on musical routines and religious parables improve communication between active residents and nursing unit residents, even the simplest puppet has a role to play at the Hermitage. McMurray uses "basic form" puppets, which express feelings nonverbally to help patients incapable of speaking. Sock puppets [see clarification farther into this article] assist Alzheimer's and other confused patients to communicate in small groups. Larger puppets, made by the residents themselves, go "on the road" with stage and props. The residents take pride in their puppet characterizations (one puppet represents a Hermitage Home board member) or particular contributions (a blind patient makes puppet hair). "Puppets help people in an institutional setting to maintain their personhood," says McMurray. "I use them to bring people to life."
ChemInform Abstract: Programming Organic Molecules: Design and Management of Organic Syntheses Through Free‐Radical Cascade Processes (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Intrahospital Spread of Vancomycin-resistant Enterococcus faecium in Sweden (1997)

During a 17-week period vancomycin-resistant Enterococcus faecium (VRE) was found in clinical specimens from 4 in-patients. All bacterial isolates were phenotypically VanA, showing high-level resistance to vancomycin (MIC 256 micrograms/ml) and teicoplanin (MIC 24-256 micrograms/ml). The corresponding gene (vanA) was detected with PCR in strains from 3 of the patients. Three patients had been hospitalized at the renal unit at Orebro Medical Centre Hospital (OMCH). The fourth patient, diagnosed in another hospital, had received treatment in the oncology unit at OMCH. All patients recovered without treatment specific for VRE. Isolates from 2 patients were indistinguishable by pulsed-field gel electrophoresis of genomic DNA. Genetically, these strains were related to the VRE isolates from the 2 other patients. Screening of hospital staff and other in-patients for gastrointestinal carriage of VRE was negative. Glycopeptide-resistant enterococci have not previously been found in OMCH. No new cases were identified during a 10-month follow-up period. Our cases represent the first nosocomial outbreak of VRE in Sweden.
Graphene Nanoplatelet Reinforced Tantalum Carbide (2015)

Abstract : In this study, Graphene nanoplatelet (GNP) reinforced tantalum carbide (TaC) composites were studied for their mechanical and thermal properties as they relate to usage as ultra high temperature materials. Samples were fabricated using Spark Plasma Sintering (SPS) and ultrahigh-pressure consolidation. The results of mechanical property testing showed GNP reinforced composites have improved modulus, hardness, damping, and damage resistance over unreinforced TaC. Results of thermal analysis during plasma oxidation testing showed an increase in thermal conductivity in GNP reinforced composites resulting in a reduction of peak sample surface temperature. This study resulted in the publications listed below and attached to this document for additional detail (the support from this grant was acknowledged in each). This award also supported the research of three graduate students (A. Nieto, C. Zhang, S. Rengifo : 1 female, 2 of Hispanic decent) and one undergraduate student (S. Thomas).
Effects of sulindac on renal and extrarenal eicosanoid synthesis (1987)

We measured the renal and extrarenal synthesis of prostacyclin and thromboxane A2, as reflected by the urinary excretion of the stable hydration products 6-keto-prostaglandin F 1 alpha and thromboxane B2 and the corresponding 2,3-dinor-derivatives, during chronic administration of sulindac (200, 400, 600, and 800 mg/day, each dose given for 7 days in successive weeks) in seven healthy subjects. Urinary eicosanoids were measured by negative ion, chemical ionization-GC/MS-validated RIA techniques. Both 2,3-dinor-thromboxane B2 and 2,3-dinor-6-keto-prostaglandin F 1 alpha showed a dose-dependent reduction, ranging between 45% and 85%. In contrast, the urinary excretion of 6-keto-prostaglandin F1 alpha and thromboxane B2 did not change significantly throughout the study. These results extend previous observations of a selective sparing of renal cyclooxygenase activity by sulindac in humans and demonstrate that this selectivity is not related to an overall weaker enzyme inhibition.
Finite element modelling of sandwich shell structures-Application to a windscreen panel (2012)

This paper presents a non-isoparametric shell finite element, which is very easy to implement in a finite element solver, for modelling of sandwich multilayered structures with a viscoelastic core. The proposed shell finite element uses only the displacements at external faces and at interlayer interfaces. Linear and quadratic variations of the displacements are assumed in the transverse direction of each layer. Exact numerical integration of the elementary stiffness and mass matrices are carried out along the thickness direction of each layer to avoid generation of solid meshes. Hence, only a 2D finite element mesh of the midsurface of the sandwich is needed, facilitating the mesh generation task. The developed shell finite element was used to calculate natural frequencies and normal modes of a car's windscreen, and associated frequency response has been computed using a simplified modal solving approach, which reduces the memory size and computing time. The simplified modal approach takes into account the frequency dependence of the mechanical properties of the polymer core. Results obtained with the developed shell element are in good agreement with those obtained using 3D hexahedral solid elements (H20) available in I-DEAS (Siemens PLM Software, Plano, TX, USA) and Nastran (Siemens PLM Software, Plano, TX, USA) software codes. Copyright © 2012 John Wiley & Sons, Ltd.