gebhart/patrepeval huggingface dataset:
Chiral Synthetic Equivalents of 2‐Cyanoethyl Tetraisopropylphosphorodiamidite: Application to the Synthesis and Resolution of Chiral Phosphoric Acids (2014)

Abstract Four synthetic equivalents of ( i Pr 2 N) 2 P‐OCH 2 CH 2 CN ( 1 ) have been prepared from readily available enantiomerically pure β‐hydroxynitriles as well as from chiral β‐hydroxy esters. To demonstrate their possible use as phosphinating/resolving agents, these phosphorodiamidites have been used in the synthesis of known phosphoric acids. The method allows enantiomerically pure acids to be obtained through separation of the diastereomeric phosphates. The method should favorably compete with other resolution procedures, e.g. fractional crystallization or chiral HPLC, for the small‐scale synthesis of new phosphoric acids for screening purposes. As synthetic equivalents of 1 , these auxiliaries might find applications also in other areas, for the synthesis of biologically relevant compounds.
ChemInform Abstract: LINKAGE ISOMERISM IN TRIMERIC AND POLYMERIC 2,3‐CIS‐PROCYANIDINS (1982)

Abstract Die Procyanidin‐Trimeren (Ia), (Ib) und (II) sowie das aus (‐)‐Epicatechin (III) gebildete Trimere (Ic) werden isoliert und strukturell aufgeklärt.
ChemInform Abstract: Synthesis of 1H‐Imidazo(1,2‐a)pyrazolo(3,4‐c)pyridines. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dynamic integration of knowledge in memory (2002)

Knowledge acquisition leads to the general problem of memory reorganization when new information is to be integrated in a system. We show in this paper how a general algorithm can be used to integrate new information into memory. A generalisation graph is developed by the algorithm using a comparison operation which is able to compare two descriptions of the knowledge. We show how this operation can be performed according to different knowledge representations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Monitoring of dissolved oxygen and cellular bioenergetics within a pancreatic substitute (2007)

This work investigated the use of nuclear magnetic resonance (NMR) spectroscopy in combination with a mathematical model of an encapsulated cell system as a method for rapidly assessing the status of a pancreatic substitute. To validate this method, an in vitro experiment was performed in which the encapsulated cells were perfused in an NMR-compatible system and the dissolved oxygen (DO) concentration of the perfusing medium was lowered from 0.20 to 0.05 mM, then returned to 0.20 mM in a stepwise fashion. The cellular metabolic activity and bioenergetics were evaluated by measuring the oxygen consumption rate (via DO sensors) and nucleotide triphosphate levels (via (31)P NMR). By incorporating a perfluorocarbon emulsion into the alginate beads, the cellular oxygenation state was monitored by measuring the average intrabead DO (AIDO) concentration by (19)F NMR. The in vitro measurements were then compared with model predictions based on the measured external DO concentration and time. Model-predicted cell growth and AIDO closely matched the experimentally acquired data. As the DO concentrations both external to and within the pancreatic substitute are needed to apply this methodology in vivo, the feasibility of measuring the DO concentration from two distinct bead populations implanted in the peritoneal cavity of mice was established. It is concluded that PFC incorporation and (19)F NMR measurements, in combination with a mechanistic model of the encapsulated system, allow the tracking of the state of a pancreatic substitute in vitro and potentially in vivo.
<title>Evanescent-wave fiber optic biosensor: challenges for real-world sensing</title> (1993)

We have developed an evanescent wave fiber optic biosensor which uses long fibers to facilitate the analysis of environmental and clinical samples for hazardous materials. The use of antibody/antigen binding with fluorescence-based sensing in the evanescent wave yields a sensor that is unique, adaptable, and sensitive. The variety of substances that could be detected is limited only by their antigenicity. Sensing in the real world poses several challenges that must be met. We have focused on the development of several aspects of the sensing system to transition this sensor into a field deployable device. Recent developments presented here include optimized fiber optic probe tapering, a flow chamber to facilitate sampling, and probe regeneration for repetitive analysis. Preliminary experiments assessing the potential to detect analytes in biological and environmental fluids are also presented.
<i>In Vivo</i> Bioluminescent Tracking of Mesenchymal Stem Cells Within Large Hydrogel Constructs (2014)

The use of multicomponent scaffolds for cell implantation has necessitated sophisticated techniques for tracking of cell survival in vivo. Bioluminescent imaging (BLI) has emerged as a noninvasive tool for evaluating the therapeutic potential of cell-based tissue engineering strategies. However, the ability to use BLI measurements to longitudinally assess large 3D cellular constructs in vivo and the effects of potential confounding factors are poorly understood. In this study, luciferase-expressing human mesenchymal stem cells (hMSCs) were delivered subcutaneously within agarose and RGD-functionalized alginate hydrogel vehicles to investigate the impact of construct composition and tissue formation on BLI signal. Results showed that alginate constructs exhibited twofold greater BLI counts than agarose constructs at comparable hMSC doses. However, each hydrogel type produced a linear correlation between BLI counts and live cell number, indicating that within a given material, relative differences in cell number could be accurately assessed at early time points. The survival efficiency of delivered hMSCs was highest for the lower cell doses embedded within alginate matrix. BLI signal remained predictive of live cell number through 1 week in vivo, although the strength of correlation decreased over time. Irrespective of hydrogel type or initial hMSC seeding dose, all constructs demonstrated a degree of vascularization and development of a fibrotic capsule after 1 week. Formation of tissue within and adjacent to the constructs was accompanied by an attenuation of BLI signal during the initial period of the image acquisition time-frame. In alginate constructs only, greater vessel volume led to a delayed rise in BLI signal following luciferin delivery. This study identified vascular and fibrotic tissue ingrowth as potential confounding variables for longitudinal BLI studies. Further investigation into the complexities of noninvasive BLI data acquisition from multicomponent constructs, following implantation and subsequent tissue formation, is warranted.
Ethyl 4-{[1-(2,4-dichlorobenzyl)-1<i>H</i>-1,2,3-triazol-4-yl]methoxy}-8-(trifluoromethyl)quinoline-3-carboxylate (2012)

In the title compound, C(23)H(17)Cl(2)F(3)N(4)O(3), the triazole ring makes dihedral angles of 50.27 (6) and 82.78 (7)° with the quinoline ring system and the dichloro-substituted benzene ring. The dihedral angle between the quinoline and dichloro-substituted benzene rings is 38.17 (4)°. In the crystal, mol-ecules are linked via C-H⋯N, C-H⋯F and C-H⋯O hydrogen bonds into a three-dimensional network. The crystal is further consolidated by C-H⋯π contacts to the triazole ring and inversion-related π-π inter-actions between the benzene and pyridine rings of quinoline systems [centroid-centroid distance = 3.7037 (7) Å].
Bayesian high-resolution reconstruction of low-resolution compressed video (2002)

A method for simultaneously estimating the high-resolution frames and the corresponding motion field from a compressed low-resolution video sequence is presented. The algorithm incorporates knowledge of the spatio-temporal correlation between low and high-resolution images to estimate the original high-resolution sequence from the degraded low-resolution observation. Information from the encoder is also exploited, including the transmitted motion vectors, quantization tables, coding modes and quantizer scale factors. Simulations illustrate an improvement in the peak signal-to-noise ratio when compared with traditional interpolation techniques and are corroborated with visual results.
The Application on Transfer Admittances to the Analysis of Power System Stability Stydies (1971)

A method is presented for analyzing the results of stability calculations using generator transfer admittances to calculate power flows between generators. It is shown that the equations for power flow from any generator to all other generators can be used to define an equivalent system bus unique to that generator. Functions which indicate the capability of a generator to maintain synchronism are presented with illustrations of their application.
A cellular ligand-field model for ‘<i>l-l</i>’ spectral intensities (1988)

The observed signs and relative magnitudes of the intensity parameters yielding good reproduction of experimental intensity distributions, as determined in the preceding paper, are shown to accord consistently with chemical and bonding features throughout the twelve tetrahedral and trigonal bipyramidal chromophores. An understanding of the intensity parameters is developed first from a qualitative viewpoint and then confirmed and developed within a semi-quantitative structure. The relationships between ligand-field and intensity parameters are discussed, particular emphasis being placed on the utility of the latter as probes of the polarity of the bond orbitals in complexes.
Automatic synthesis of customized local memories for multicluster application accelerators (2004)

Distributed local memories, or scratchpads, have been shown to effectively reduce cost and power consumption of application-specific accelerators while maintaining performance. The design of the local memory organization must take several factors into account, including the memory bandwidth and size requirements of the program and the distribution of program data among the memories. In addition, when register structures and function units in the accelerator are clustered, the effects of intercluster communication should be taken into account. This work proposes a technique to synthesize the local memory architecture of a clustered accelerator using a phase-ordered approach. First, the dataflow graph is pre-partitioned to define a performance-centric grouping of the operations. Second, memory synthesis is performed by combining multiple data structures into a set of physical memories that minimizes cost while maintaining a performance threshold. Finally, post-partitioning is performed to determine the final assignment of operations to clusters given the memory organization. Results show that customization reduces memory cost from 2% to 59% over a naive scheme that utilizes one physical memory per program data structure. Further, pre-partitioning is shown to reduce the intercluster communication required to achieve a fixed performance.
La vie posthume d'Edouard Manet : l'art national et la biographie artistique au début de la IIIe République (1996)

En janvier 1884, la première rétrospective majeure de l'œuvre d'Edouard Manet fut organisée. Cet événement donna l'occasion aux écrivains, critiques d'art et administrateurs culturels alliés aux factions diverses du bloc républicain au pouvoir d'inscrire Manet dans l'histoire d'un « art national » et d'une culture républicaine. Mais afin « d'officialiser » Manet, ses partisans républicains devaient reformuler sa carrière. Il leur fallait réévaluer son œuvre de façon à contrecarrer directement l'image de « rapin scandaleux » que les critiques conservateurs donnaient de l'artiste : le Manet du Déjeuner sur l'herbe et de l'infâme Olympia. Le Manet officiel devait être domestiqué, reformulé et réinventé selon des conceptions différentes quant à son rôle dans le développement de la peinture moderne.
Asymmetric Catalysis with Substitutionally Labile yet Stereochemically Stable Chiral-at-Metal Iridium(III) Complex (2014)

A metal-coordination-based high performance asymmetric catalyst utilizing metal centrochirality as the sole element of chirality is reported. The introduced substitutionally labile chiral-at-metal octahedral iridium(III) complex exclusively bears achiral ligands and effectively catalyzes the enantioselective Friedel-Crafts addition of indoles to α,β-unsaturated 2-acyl imidazoles (19 examples) with high yields (75%-99%) and high enantioselectivities (90-98% ee) at low catalyst loadings (0.25-2 mol %). Counterintuitively, despite its substitutional lability, which is mechanistically required for coordination to the 2-acyl imidazole substrate, the metal-centered chirality is maintained throughout the catalysis. This novel class of reactive chiral-at-metal complexes will likely be of high value for a large variety of asymmetric transformations.
CYTOLOGY AND ITS OFFICE APPLICATION AS VIEWED BY THE PATHOLOGIST (1962)

From The Institute of Pathology, Western Reserve University School of Medicine and the University Hospitals of Cleveland, Cleveland, Ohio
Thermochemical Aspects of Polymerization. Equilibrium Copolymerization (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermochemical Aspects of Polymerization. Equilibrium CopolymerizationMichael H. TheilCite this: Macromolecules 1969, 2, 2, 137–142Publication Date (Print):March 1, 1969Publication History Published online1 May 2002Published inissue 1 March 1969https://pubs.acs.org/doi/10.1021/ma60008a005https://doi.org/10.1021/ma60008a005research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adenovirus Regulates Sumoylation of Mre11-Rad50-Nbs1 Components through a Paralog-Specific Mechanism (2012)

The Mre11-Rad50-Nbs1 (MRN) complex plays a key role in the DNA damage response, presenting challenges for DNA viruses and retroviruses. To inactivate this complex, adenovirus (Ad) makes use of the E1B-55K and E4-open reading frame 6 (ORF6) proteins for ubiquitin (Ub)-mediated, proteasome-dependent degradation of MRN and the E4-ORF3 protein for relocalization and sequestration of MRN within infected-cell nuclei. Here, we report that Mre11 is modified by the Ub-related modifier SUMO-2 and Nbs1 is modified by both SUMO-1 and SUMO-2. We found that Mre11 and Nbs1 are sumoylated during Ad5 infection and that the E4-ORF3 protein is necessary and sufficient to induce SUMO conjugation. Relocalization of Mre11 and Nbs1 into E4-ORF3 nuclear tracks is required for this modification to occur. E4-ORF3-mediated SUMO-1 conjugation to Nbs1 and SUMO-2 conjugation to Mre11 and Nbs1 are transient during wild-type Ad type 5 (Ad5) infection. In contrast, SUMO-1 conjugation to Nbs1 is stable in cells infected with E1B-55K or E4-ORF6 mutant viruses, suggesting that Ad regulates paralog-specific desumoylation of Nbs1. Inhibition of viral DNA replication blocks deconjugation of SUMO-2 from Mre11 and Nbs1, indicating that a late-phase process is involved in Mre11 and Nbs1 desumoylation. Our results provide direct evidence of Mre11 and Nbs1 sumoylation induced by the Ad5 E4-ORF3 protein and an important example showing that modification of a single substrate by both SUMO-1 and SUMO-2 is regulated through distinct mechanisms. Our findings suggest how E4-ORF3-mediated relocalization of the MRN complex influences the cellular DNA damage response.
Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo (2008)

Besides their well-characterized proinflammatory and proatherogenic effects, oxidized phospholipids, such as oxPAPC (oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-phosphocholine) have been shown to have beneficial responses in vascular cells via induction of antioxidant enzymes such as heme oxygenase-1. We therefore hypothesized that oxPAPC could evoke a general cytoprotective response via activation of antioxidative transcription factor Nrf2. Here, we show that oxPAPC increases nuclear accumulation of Nrf2. Using the small interfering RNA approach, we demonstrate that Nrf2 is critical in mediating the induction of glutamate-cysteine ligase modifier subunit (GCLM) and NAD(P)H quinone oxidoreductase-1 (NQO1) by oxPAPC in human endothelial cells, whereas the contribution to the induction of heme oxygenase-1 was less significant. The induction of GCLM and NQO1 was attenuated by reduction of electrophilic groups with sodium borohydrate, as well as treatment with thiol antioxidant N-acetylcysteine, suggesting that the thiol reactivity of oxPAPC is largely mediating its effect on Nrf2-responsive genes. Moreover, we show that oxidized phospholipid having a highly electrophilic isoprostane ring in its sn-2 position is a potent inducer of Nrf2 target genes. Finally, we demonstrate that the oxPAPC-inducible expression of heme oxygenase-1, GCLM, and NQO1 is lower in Nrf2-null than wild-type mouse carotid arteries in vivo. We suggest that the activation of Nrf2 by oxidized phospholipids provides a mechanism by which their deleterious effects are limited in the vasculature.
Ag<sub>3.5</sub>Bi<sub>7.5</sub>S<sub>13</sub>, a New Member (N = 8) of the Homologous Series [Bi<sub>2</sub>S<sub>3</sub>]<sub>2</sub>× [AgBiS<sub>2</sub>]<sub>(N—1)/2</sub>. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
A dynamic model for the temporal properties of Swedish (1993)

The segment duration varies depending on a number of linguistic and nonlinguistic factors. At the word and phrase levels, the segment duration is found to vary depending on the position in the work and in the phrase. The positional effects on segment duration have been studied by several investigators and, for some languages, models have been hypothesized in order to describe the duration of speech segments in different positions in words and phrases. The greatest positional effect is the phenomenon of final lengthening that appears to be of considerable generality as a phonetic phenomenon. Most computational models for segment duration are, however, static, i.e., the durational properties are modeled at a certain speech rate. In this investigation the segment duration is studied at different speech rate and with focus assignment systematically varied along the sentence. The segment duration values are studied by means of both reiteratant speech and ordinary read speech. A tentative dynamic model for the segment duration is presented.
Oral findings, treatment and follow-up of a case with major aphthous stomatitis (Sutton's disease). (1994)

Major aphthous stomatitis (Sutton's disease) is a clinical variant of recurrent aphthous stomatitis, which is noted for its high morbidity. Since the etiology of the disease is not clear, many therapies have been attempted. However, the controversial results hinder the adoption of a single mode of management. We present a 13-year-old boy with Sutton's disease, who was successfully treated with a combination of burst systemic prednisone (1 mg/kg/day for five days, thereafter half dose on alternate days for one week) and topical triamcinolone (four rinses a day). He continued the mouth rinses with the same interval. At the end of the first month, significant healing was observed and gradual tapering was recommended on the condition that the ulcers were well-controlled. The maintenance of steroid rinse once a day provided a symptom-free period of one year. Neither any withdrawal signs nor side affects were observed. Therefore, we think that this regimen should be considered as the treatment of choice in Sutton's disease along with a close follow-up even in childhood.
An Automated Design Framework for Floating Point Scientific Algorithms using Field Programmable Gate Arrays (FPGAs) (Abstract Only) (2015)

This paper presents a reconfigurable computing environment while addressing the problem of porting High Performance Computing (HPC) applications directly to Field Programmable Gate Arrays (FPGAs)-based architectures. The objectives of this research are developing a comprehensive floating point library of essential functions for scientific applications; demonstrate order of magnitude speedup of reconfigurable computing applications, demonstrating the effectiveness of automated design framework for both development and test of scientific algorithms. The developed framework can be reused in various scientific applications which shares kernel functions. The study of this research has identified an exponential function as a kernel for cellular ophthalmoscopy camera processing, traffic monitoring and light wave simulation. The paper demonstrates 30x speedup of these kernels in three algorithms using its novel architecture and its automated toolset. Exponential kernel generation case study and its flexible hardware implementation on an FPGA has been validated onto a Xilinx LX-100 device and the Nallatech H101-PCIXM FPGA board.
Applying a Service-Based Architecture Design Style to Network Functions Virtualization (2018)

This article presents a proposed an evolution of the Network Functions Virtualization (NFV) architectural framework towards a Service-Based Architecture (SBA), where management and orchestration services can be dynamically registered and discovered.