gebhart/patrepeval huggingface dataset:
Effects of small C-ANF receptor ligands on plasma levels of atrial natriuretic factor, blood pressure, and renal function in the rat (1991)

In this article, after a very brief review on ANF receptors, we report our study on the effects of small C-ANF receptor ligands in the rat. Two small ligands were synthesized: 2-naphthoxyacetyl-isonipecotyl-rANF11-15-NH2 (5 aa), containing 5 amino acids; and Ala7-rANF8-17-NH2 (10 aa), containing 10 amino acids from the ring structure of ANF1-28. After control periods, 5 aa or 10 aa were infused i.v. at a dose of 10 micrograms.min-1.kg-1 body weight for 70 min in anesthetized rats, followed by a 60-min recovery period. The 5 aa and 10 aa peptides significantly and reversibly increased plasma levels of endogenous immunoreactive ANF by 106 +/- 29 and 52 +/- 24 pg/mL, respectively. Infusion of the 5 aa peptide significantly decreased mean arterial blood pressure from 113 +/- 1 to 100 +/- 3 mmHg (1 mmHg = 133.32 Pa) and increased glomerular filtration rate from 1.6 +/- 0.2 to 2.3 +/- 0.2 mL/min, sodium excretion from 0.6 +/- 0.3 to 3.4 +/- 0.4 mumol/min, and potassium excretion from 0.5 +/- 0.2 to 1.2 +/- 0.2 mumol/min. Similar results were obtained with the 10 aa peptide. The effects of both peptides on blood pressure and sodium excretion persisted throughout the recovery period. The results confirm and extend previous observations showing that C-ANF receptors mediate the removal of ANF from the circulation. The shortening of the minimal peptide length necessary to bind to C-ANF receptors markedly enhances the possibility of developing orally active C-ANF receptor ligands for the treatment of cardiovascular and renal diseases.
Introduction of a new reflective framework to enhance students’ simulation learning : a preliminary evaluation (2009)

Original article can be found at : http://www.herts.ac.uk/
Consideration on the CO and NO Formation around the Coke Specimen during Combustion (1980)

An apparatus was deviced for the analysis of CO2, CO and NO in the small amount of the gas sampled around the coke specimen during combustion. The conversion ratio of organic nitrogen in coke to NO was calculated from the analytical results of these gases.According to the analysis of the conversion ratio, the reaction of NO formation was indicated to proceed both on the coke surface and within the boundary layer. The former reaction on the surface gave the most of NO. The reduction of NO formation was brought with elevating the CO/O2 ratio at the coke surface.
Graphitization of amorphous carbon and its transformation pathways (2013)

The graphitic ordering of the amorphous state of carbon has been a long-standing challenge. Whilst there are numerous transformation methodologies, including the high-temperature-pressure approach, there are still many unclear elements concerning the mechanism. By employing classical molecular dynamics simulations, the process of graphitization of amorphous carbon is modelled and analyzed. A systematic study of various schemes of loading conditions suggests that (1) axial strain is a vital ingredient in the transformation, and (2) there exists a close relationship between the mean layer atomic density of the amorphous carbon structure and the graphitization process. Furthermore, the non-simultaneity (i.e., in a delayed manner) of structure loading (by high-temperature annealing and straining) promotes a greater extent of graphitization, as compared to a concurrent means. More interestingly, edge and non-edge bonds behave dissimilarly in response to a change in the atomic density, and graphitization prevails at different stages of the fast and slow loading schemes. Virial pressure calculations validate the structural stability.
Ex-ante and ex-post coping strategies for climatic shocks and adaptation determinants in rural Malawi (2019)

This paper assesses farmers’ experiences with different climatic shocks as well as their ex-ante and ex-post coping strategies for climatic risks and shocks in rural Malawi. The paper is based on a comprehensive data set collected in 2013 from 1582 farm households located in three regions of Malawi (northern, central, and eastern). The study uses a bivariate probit model to examine the role of farm characteristics—including physical, human, social, and financial capital—in the household’s decision to adapt to climatic shocks. The results revealed that farmers in the study area experienced droughts, floods, and crop pests and diseases as key climatic shocks. Additionally, some indirect climatic shocks reported by farmers include crop damages, increases in input and output prices, and reductions in farm profit. Farmers adopted more on-farm work, drought-tolerant varieties, early planting, and intercropping as key ex-ante adaptation strategies to reduce the adverse impacts of extreme climate events. Farmers adopted drought and disease-tolerant crops, diversified their crops, planted earlier, did more on-farm work, and changed their eating habits as key ex-post climatic shock coping strategies. Furthermore, social networks and capital were found to be important factors influencing farmers’ adaptation decisions. The study suggests improving access to community resources, infrastructure, and information in order to improve household capacity to cope with climatic shocks.
Interaction of peptide boronic acids with elastase: Circular dichroism studies (1988)

Boronic acid derivatives of good peptide substrates of the serine proteases cause slow-binding inhibition, manifested as biphasic binding (Kettner and Shenvi: J. Biol Chem. 259:15106-15114, 1984). These inhibitors are thought to act as reaction-intermediate analogs. Three peptide boronic acids--Ac-Pro-boro-Val-OH, DNS-Ala-Pro-boro-Val-OH, and Ac-Ala-Ala-Pro-boro-Val-OH--were chosen for far-ultraviolet circular dichroism (CD) studies in order to determine whether the second phase involves a conformational change of pancreatic elastase. The dipeptide is a simple competitive inhibitor (Ki = 0.27 microM) and the latter are slow-binding inhibitors (Ki = 16.4 and 0.25 nM, respectively). Spectral deconvolution and correction for the formation of antiparallel beta-sheet by the peptide inhibitor itself indicate that there is no significant change in the secondary structure of the enzyme in either the initial or final inhibitor complex. A kinetic experiment confirmed that the slow-binding step was not associated with a CD spectral change, and that therefore a protein conformational change was not responsible for the slow binding.
Can the question 'Does Literature Exist' persist? (2009)

A response by Robert Lumsden to ‘Does Literature Exist? A Transnational Symposium’ published in Volume 1 no. 1.
Construction of Nomographs with Hyperbolic Coordinates (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConstruction of Nomographs with Hyperbolic CoordinatesWalter Herbert BurrowsCite this: Ind. Eng. Chem. 1946, 38, 5, 472–477Publication Date (Print):May 1, 1946Publication History Published online1 May 2002Published inissue 1 May 1946https://pubs.acs.org/doi/10.1021/ie50437a012https://doi.org/10.1021/ie50437a012research-articleACS PublicationsRequest reuse permissionsArticle Views21Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Complete Genome Sequence of the Photosynthetic Purple Nonsulfur Bacterium <i>Rhodobacter capsulatus</i> SB 1003 (2010)

Rhodobacter capsulatus SB 1003 belongs to the group of purple nonsulfur bacteria. Its genome consists of a 3.7-Mb chromosome and a 133-kb plasmid. The genome encodes genes for photosynthesis, nitrogen fixation, utilization of xenobiotic organic substrates, and synthesis of polyhydroxyalkanoates. These features made it a favorite research tool for studying these processes. Here we report its complete genome sequence.
Carbon monoxide-binding properties of the cytochrome<i>bo</i>quinol oxidase complex in<i>Escherichia coli</i>are changed by copper deficiency in continuous culture (1992)

A strain of Escherichia coli having elevated levels of cytochrome bo and lacking the cytochrome bd quinol oxidase was grown in chemostat culture at low copper levels. Such cells had lowered levels of copper and of total cytochrome b. Cytochrome o concentration was unchanged when assayed by conventional CO difference spectroscopy, but apparently diminished by 80% in copper-deficient cells as determined by photodissociation of bound CO at 193 K. This is attributed to depletion of copper in the oxidase of copper-deficient cells, causing rapid recombination of photodissociated CO to haem O. CO recombination was also more sensitive to low intensities of actinic light in copper-depleted oxidase. The results illustrate a further similarity between the active sites of o- and aa3-type terminal oxidase.
Adherence phenotype of HBHA produced by <em>Mycobacterium avium</em> subsp <em>paratuberculosis</em> type C and S (2012)

Communication orale
An ab initio electronic transport database for inorganic materials (2017)

Electronic transport in materials is governed by a series of tensorial properties such as conductivity, Seebeck coefficient, and effective mass. These quantities are paramount to the understanding of materials in many fields from thermoelectrics to electronics and photovoltaics. Transport properties can be calculated from a material's band structure using the Boltzmann transport theory framework. We present here the largest computational database of electronic transport properties based on a large set of 48,000 materials originating from the Materials Project database. Our results were obtained through the interpolation approach developed in the BoltzTraP software, assuming a constant relaxation time. We present the workflow to generate the data, the data validation procedure, and the database structure. Our aim is to target the large community of scientists developing materials selection strategies and performing studies involving transport properties.
A Sign Inversion Mechanism for Enzymatic Supercoiling of DNA (1979)

Both the introduction and the removal of supertwists by DNA gyrase change the linking number of DNA in steps of two. This surprising finding provides strong evidence that gyrase acts by a mechanism, called sign inversion, whereby a positive supercoil is directly inverted into a negative one via a transient double-strand break.
A synthesis of 2-(substituted phenyl)-propionic acid. I. An alternate synthesis of 2-(4-isobutylphenyl)-propionic acid. (1975)

2-(4-Isobutylphenyl)-propionic acid, which is known to have a high anti-inflammatory activity and has widely been used in the treatment of diseases caused by inflammation, such as rheumatism, was synthesized from methyl 3-methyl-3-(4-isobutylphenyl)-glycidate, via methyl 2-hydroxy-3-(4-isobutylphenyl)-3-butenoate (VI) in four steps.
ChemInform Abstract: Synthesis Studies Directed Towards Epothilone A: Enantioselective Synthesis of a C<sub>7</sub>—C<sub>15</sub> Carboxaldehyde Segment. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Compressed Air Storage and Wind Energy for Time-of-day Electricity Markets (2013)

As renewable energy generating capacity increases on electricity grids, technology is needed to balance the supply and demand of energy. In order to manage the demand side of electricity, time-of-day (TOD) tariffs are a simple economic mechanism that encourages consumers to smooth the diurnal demand profile by shifting consumption to off-peak times. The management of supply by renewable energy generators can be achieved using energy storage. This study investigates the use of compressed air energy storage (CAES) to de-couple a wind energy converter (WEC) from the electricity grid and manage its power output. Numerical and thermodynamic models simulate the operation of the system. One year of operation is simulated using 10 minute WEC time-step data for varying CAES capacities in order to optimize the economic performance of the total system. By selling electricity according to TOD tariff schedules, the income generated by a 0.8 MW WEC using a 4 MWh CAES system is increased by 30%. The CAES has a round-trip efficiency of 66% and annually experiences 450 deep cycles as it stores 25% of the energy generated by the WEC.
Cenelec and IEC Standards on EMC of Equipment and Cable Distribution Networks for Sound and Television Signals: Present Status and Future Developments (2002)

The aim of this paper is to consider the present situation of the European and international EMC standards concerning the methods of measurement for the radiation characteristics and for the evaluation of the immunity requirements of equipment and cable networks for sound and television signals. It is divided in several parts as follows. Background - A brief note about the evolution of the European and International EMC standards dealing with cable distribution networks. EMC of equipment - A review of the radiation and immunity limits for active and passive equipment recommended by CENELEC EN 50083-2 is given. Comparison of equipment limits - The differences between the radiation limits and immunity requirements for network equipment given in CENELEC EN 50083-2, for broadcast TV and FM sound receivers and associated equipment, given in IEC CISPR 13 (emission) and CISPR 20 (immunity) standards, and for Telecommunication equipment given in ETSI are shown in comparative tables. EMC of cable distribution networks - The philosophy of the European measuring methods for evaluating the immunity requirements of the cable network as given in EN 50083-8 is different to that given in international standards in particular in the North America (U.S.A and Canada) standards. The differences are mainly due to the quite different technical solutions for installations used in these Countries, overhead or underground distribution cables. Present and future activities - The problem to update the present standards including equipment for digital and multimedia signals (other than analogue signals) and harmonize them with ETSI standards, is considered and discussed, and the present activity of CENELEC in this field is illustrated. The harmonization of CENELEC and ETSI standards is very important for manufactures because the goal is to avoid to test two times (with different standards) the equipment that can be used in cable networks either for analogue or digital and for multimedia signals, as it occurs today. Conclusions. The considered standards have many advantages but also some disadvantages which are noted for the future works of the relevant organizations.
Paterson Strike Pageant (1971)

On June 7, 1913, the Industrial Workers of the World presented the Paterson Strike Pageant at Madison Square Garden. It was a powerful and innovative use of the pageant form: On a huge stage, more than 200 feet long and capable of holding more than 1,000 performers, workers from silk factories at Paterson, New Jersey, recreated the central events of their strike, which was led by the IWW. The strike had begun in February. By June, two workers had been killed by random gunfire from police and private detectives hired by the mill owners. Nearly 1,500 strikers and sympathizers had been arrested. Among those arrested was the young journalist John Reed, who was later to write Ten Days That Shook the World .
Influence of decreasing solvent polarity (1,4-dioxane/water mixtures) on the stability and structure of complexes formed by copper(II), 2,2′-bipyridine or 1,10-phenanthroline and guanosine 5′-diphosphate: evaluation of isomeric equilibria (2008)

Abstract The stability constants of the 1 : 1 complexes formed between Cu(Arm)2+, where Arm = 2,2′-bipyridine or 1,10-phenanthroline, and guanosine 5′-diphosphate (GDP)3− or its monoprotonated form H(GDP)2− were determined by potentiometric pH titrations in water and in water containing 30 or 50% (v/v) 1,4-dioxane (25°C; I = 0.1 M, NaNO3). The stability of the binary Cu(GDP)− complex is enhanced due to macrochelate formation of the diphosphate-coordinated Cu2+ with N7 of the guanine residue as previously shown. In Cu(Arm)(GDP)− the N7 is released from Cu2+ and the stability enhancement of more than one log unit in aqueous solution is clearly attributable to intramolecular stack formation between the aromatic rings of Arm and the guanine moiety. Indeed, stacked isomers occur to more than 90% in equilibrium with open unstacked forms. Surprisingly, the same formation degrees of the stacks are observed for Cu(Arm)(dGMP) complexes, where dGMP2− = 2′-deoxyguanosine 5′-monophosphate, despite the fact that the overall stability of the latter species is by about 2.7 log units lower. In 1,4-dioxane–water mixtures stack formation is drastically reduced, probably due to hydrophobic solvation of the aromatic rings by the ethylene bridges of 1,4-dioxane. The relevance of these results regarding biological systems is indicated. †This study is dedicated to Professor Dr Alfredo Mederos on the occasion of his retirement from the University of La Laguna (Spain) with the very best wishes for all of his future endeavors. ‡This is part 70 of the series Ternary Complexes in Solution; for parts 69 and 68 see Citation14 and Citation15, respectively. Keywords: Aromatic-ring stackingIsomeric equilibriaMixed solventsNucleotide complexesStability constants Acknowledgements We thank Mrs Astrid Sigel for her competent help in the preparation of this manuscript and the Department of Chemistry of the University of Basel for financial support. Notes †This study is dedicated to Professor Dr Alfredo Mederos on the occasion of his retirement from the University of La Laguna (Spain) with the very best wishes for all of his future endeavors. ‡This is part 70 of the series Ternary Complexes in Solution; for parts 69 and 68 see Citation14 and Citation15, respectively.
A service plane architecture for future optical Internet (2009)

The advent of new Internet applications and services has seen an increase in heterogeneity and complexity in service provisioning. These services require high-end non-network (storage and computing) resources interconnected by high capacity optical network. To support these services efficient coordination of optical network and non-network resources is required, which in turns requires accurate resource state information. To address this requirement a novel service oriented optical network architecture is introduced. Central to the proposed architecture is a novel service plane. The service plane orchestrates and facilitates interconnection of heterogeneous optical networks, non-network resources and clients. It utilizes a service oriented resource discovery platform that presents different abstraction models to facilitate resource state information discovery and dissemination. Finally, in this paper several novel resource abstraction models for the proposed service plane are presented and their performance is evaluated.
Waste minimization in a non-production oriented metal finishing operation (1991)

This paper provides information on activities undertaken in a non- production oriented metal finishing operation to minimize waste and conserve resources. The facility is a 6000 sq foot shop that typically only deals with prototype parts. Utilizing a plan that includes employee awareness, common sense and existing technology, a noticeable reduction in waste volume has been obtained. Initiatives that are covered include: segregation of cyanide plating solutions, elimination of copper cyanide plating, elimination of hexavalent chromium plating, elimination of vapor degreasing, changing of rinsing practices, and changing a process for cleaning of aluminum parts. Some discussion is also presented on the effectiveness of combining the technologies of physical vapor deposition and electrodeposition to help minimize waste. Plans for additional initiatives including water recycling, elimination of cyanide plating and substitution of electrodeposition for electroless deposition of Ni-P alloys are also covered.
Structure of tetrahydro-N-methyl-2-(2-pyridinyl)-2-thiophenecarbothioamide (picartamide) (1990)

CllH14N2S2, Mr = 23837, monoclinic, P2~/c, a = 8.760 (3), b = 8.732 (2), c = 16.353 (4) A, fl=112.02(5) ° , V =11853(5)/~3, Z=4, Dr,= 1.334 (2), Dx = 1.336 g cm -3, A(fu Kce) = 1-5418/~, /z = 37.53 cm- ~, F(000) = 504, T = 293 K, R = 0-045 for 1983 observed reflections. The tetrahydro-2- thiophene ring takes a/3-envelope configuration and is linked with the thiocarboxamide group by an intramolecular N--H...S hydrogen bond. The NH group is intermolecularly hydrogen-bonded to the pyridine N atom, thus forming a 'cyclic' dimer structure between two centrosymmetrically related molecules.
Seismic Inversion Based SRV and Reserves Estimation for Shale Plays (2017)

Abstract Estimation of stimulated rock volume (SRV) is the cornerstone offield development planning in shale reservoirs. The EUR has a first order dependency on the SRV and therefore its estimation is extremely critical for field development. In this paper, we propose a methodology to estimate the SRV and hence the EUR for a shale reservoir using seismic data, flow and geomechanical simulation. The backbone of our methodology is seismic inversion coupled with geomechanical simulation. We apply our technique to data acquired from the Barnett shale. In this work, we first use 3D seismic and sonic logs to perform pre-stack seismic inversion. Then, we derive the distribution of Poisson's ratio and Young's modulus in the area of interest (AOI). We constrain the porosity in our geo cellular model using a rock type model. Our rock type model for this work is based on k-means clustering on multi-well log analysis. We modeled a well in the AOI for which microseismic data is available. Weused a coupledflow and geomechanical simulator to mimic the fracturing process and the fluid volumes injected during the actual completion of the well. For geomechanical coupling, we used Barton-Bandis model in seismic inversion-derived Young's modulus and Poisson's ratio 3D volumes. Next, we compare our results with the SRV obtained by an analysis of microseismic data. We reconcile differences in the model-derived SRV and then calibrate the resulting flow model and use the history-matched model for forecasting production. Our results indicate an excellent match on SRV and therefore production data. Because we usevariable geomechanical parameters along the lateral, we observe irregular SRV's and drainage areas consistent with the microseismic data. Our methodology for predicting microseismic can be used for asset evaluation, acreage prioritization and to optimize the completion design in unconventional plays.