gebhart/patrepeval huggingface dataset:
Lipopolysaccharide O1 Antigen Contributes to the Virulence in Klebsiella pneumoniae Causing Pyogenic Liver Abscess (2012)

Klebsiella pneumoniae is the common cause of a global emerging infectious disease, community-acquired pyogenic liver abscess (PLA). Capsular polysaccharide (CPS) and lipopolysaccharide (LPS) are critical for this microorganism's ability to spread through the blood and to cause sepsis. While CPS type K1 is an important virulence factor in K. pneumoniae causing PLA, the role of LPS in PLA is not clear. Here, we characterize the role of LPS O antigen in the pathogenesis of K. pneumoniae causing PLA. NTUH-K2044 is a LPS O1 clinical strain; the presence of the O antigen was shown via the presence of 1,3-galactan in the LPS, and of sequences that align with the wb gene cluster, known to produce O-antigen. Serologic analysis of K. pneumoniae clinical isolates demonstrated that the O1 serotype was more prevalent in PLA strains than that in non-tissue-invasive strains (38/42 vs. 9/32, P<0.0001). O1 serotype isolates had a higher frequency of serum resistance, and mutation of the O1 antigen changed serum resistance in K. pneumoniae. A PLA-causing strain of CPS capsular type K2 and LPS serotype O1 (i.e., O1:K2 PLA strain) deleted for the O1 synthesizing genes was profoundly attenuated in virulence, as demonstrated in separate mouse models of septicemia and liver abscess. Immunization of mice with the K2044 magA-mutant (K(1) (-) O(1)) against LPS O1 provided protection against infection with an O1:K2 PLA strain, but not against infection with an O1:K1 PLA strain. Our findings indicate that the O1 antigen of PLA-associated K. pneumoniae contributes to virulence by conveying resistance to serum killing, promoting bacterial dissemination to and colonization of internal organs after the onset of bacteremia, and could be a useful vaccine candidate against infection by an O1:K2 PLA strain.
Neural Mechanisms of Selective Visual Attention (1995)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Characterisation of short pulse laser target debris at the HELEN laser facility (2005)

The implementation of CPA on one of the HELEN laser beams has prompted the need for investigations into the survivability of reflective and refractive focussing optics during laser-target interaction experiments. These experiments generate debris that has the potential to contaminate the optics cumulatively over time, and in some cases produce high-energy shrapnel, which may damage the focussing optics on an individual shot. Inserting a thin (2mm) coated glass substrate into the beam path allows for its use as a mitigation shield by obstructing the line of sight for debris and shrapnel to travel directly from the target to the focussing optic. A series of experiments have been conducted using such debris shields on the CPA beam line at the HELEN laser facility AWE, Aldermaston. The influence of the debris shield on focal spot behaviour will be described. Directionality and contamination density of target debris has been characterised by the use of thin glass witness plates and post-shot inspection by optical microscopy.
The latent heat of fusion of cis and trans decahydronaphthalene (2012)

No abstract
Java Enterprise in a Nutshell (2005)

Nothing is as constant as change, and this is as true in enterprise computing as anywhere else. With the recent release of Java 2 Enterprise Edition 1.4, developers are being called on to add even greater, more complex levels of interconnectivity to their applications. To do this, Java developers today need a clear understanding of how to apply the new APIs, use the latest open source Java tools, and learn the capabilities and pitfalls in Java 2 Enterprise Edition 1.4 -- so they can plan a technology and implementation strategy for new enterprise projects. Fortunately, this is exactly what they get with the new Java Enterprise in a Nutshell, 3rd Edition. Because most integrated development environments (IDE) today include API lookup, we took out the main API sections from our previous edition to make room for new chapters, among others, on Ant, Cactus, Hibernate, Jakarta Struts, JUnit, security, XDoclet, and XML/JAXP. Revised and updated for the new 1.4 version of Sun Microsystems Java Enterprise Edition software, Java Enterprise in a Nutshell, 3rd Edition is a practical guide for enterprise Java developers.
Investigations of the origin of phase differences seen with ultrashort TE imaging of short T2 meniscal tissue (2011)

Ultrashort echo time MRI requires specialized pulse sequences with nominal echo times as low as a few microseconds to detect signals from the short T(2) tissues frequently encountered in the musculoskeletal system. Usually, magnitude images are reconstructed and these often show low tissue contrast. Ultrashort echo time phase images of the meniscus show surprisingly high contrast despite their very short echo time. In this article, we investigated the source of this contrast using the Bloch equations, simulations, phantom experiments, and tissue studies. Phase evolution was shown to occur in ultrashort echo time sequences during the finite radiofrequency pulse and readout periods, and previously unrecognized susceptibility differences between fiber groups were observed in the meniscus.
Mucoadhesive Delivery Systems. I. Evaluation of Mucoadhesive Polymers for Buccal Tablet Formulation (2004)

Different types of mucoadhesive polymers, intended for buccal tablet formulation, were investigated for their comparative mucoadhesive force, swelling behavior, residence time and surface pH. The selected polymers were carbopols (CP934, and CP940), polycarbophil (PC), sodium carboxymethyl cellulose (SCMC) and pectin representing the anionic type, while chitosan (Ch) as cationic polymer and hydroxypropylmethyl cellulose (HPMC) as a non-ionic polymer. Results revealed that polyacrylic acid derivatives (PAA) showed the highest bioadhesion force, prolonged residence time and high surface acidity. SCMC and chitosan ensured promising bioadhesive characteristics, whilst HPMC and pectin exhibited weaker bioadhesion. Different polymer combinations as well as formulations were evaluated to improve the mucoadhesive performance of the tablets. Bioadhesive tablet formulations containing either 5% CP934, 65% HPMC and 30% spray-dried lactose or 2% PC, 68% HPMC and 30% mannitol showed optimum mucoadhesion and suitable residence time. SCMC, when formulated individually, exhibited promising bioadhesion, acceptable swelling, convenient residence time and surface pH. In-vivo trials of these formulations proved non-irritative and prolonged residence of the mucoadhesive tablets on human buccal mucosa for 8 to 13 h.
License integration patterns: Addressing license mismatches in component-based development (2009)

In this paper we address the problem of combining software components with different and possibly incompatible legal licenses to create a software application that does not violate any of these licenses while potentially having its own. We call this problem the license mismatch problem. The rapid growth and availability of open source software (OSS) components with varying licenses, and the existence of more than 70 OSS licenses increases the complexity of this problem. Based on a study of 124 OSS software packages, we developed a model which describes the interconnection of components in these packages from a legal point of view. We used our model to document integration patterns that are commonly used to solve the license mismatch problem in practice when creating both proprietary and OSS applications. Software engineers with little legal expertise could use these documented patterns to understand and address the legal issues involved in reusing components with different and possibly conflicting licenses.
High-voltage multilevel converter with regeneration capability (2002)

This paper presents a multilevel converter with regeneration capability. The converter uses several power cells connected in series, each working with reduced voltage and with an active front end at the line side. This paper presents the following: (1) the control method of each cell; (2) the use of phase-shifting techniques to reduce the current and voltage distortion; and (3) criteria to select the connection of the cells. The converter generates almost sinusoidal currents at the load and at the input and works with very high power factor.
Luminescence study of the adsorption of ammonia and other simple molecules on an activated europium ion exchanged mordenite (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLuminescence study of the adsorption of ammonia and other simple molecules on an activated europium ion exchanged mordeniteTsuyoshi Arakawa, Midori Takakuwa, and Jiro ShiokawaCite this: Inorg. Chem. 1985, 24, 23, 3807–3810Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/ic00217a022https://doi.org/10.1021/ic00217a022research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
STADTVERKEHR DER ZUKUNFT (1973)

KONSTRUKTIONSMERKMALE, LEISTUNG, VERWENDUNGSBEREICH UND STAND DER ENTWICKLUNG VON 16 NEUARTIGEN STADT- UND NAHVERKEHRSMITTELN SIND IN EINER TABELLE ZUSAMMENGEFASST. NAEHER ERLAEUTERT WERDEN KABINENTAXI (DEMAG/MBB), TRANSURBAN -MAGNETSCHWEBETECHNIK (KRAUSS-MAFFEI), H-BAHN-KABINENSYSTEM (SIEMENS), AEROBUS (OVERGROUND-TRAFFIC-SYSTEM), ELAN-SIG-SYS TEM, MAGNA-CAB-SYSTEM (MC-SYSTEM), AIRCAB-SYSTEM UND EINE AIRCAB-KABINENBAHN. SIE SOLL DEM NAHVERKEHR IM BEREICH VON HOCH-, BUERO- UND WARENHAEUSERN DIENEN. IHRE FAHRZEUGE WERDEN AN DEN HALTESTELLEN, DIE IN VERSCHIEDENEN STOCKWERKEN DES HAUSES LIEGEN KOENNEN, DURCH LIFTE ZUGEFUEHRT. (A*).
George S. Wehrwein: The Economist's Approach to Ecology (1995)

his year marks the 50th anniversary of the passing of George s.Wehrwein (1883Wehrwein ( -1945)), president of the American Farm Economic Association in 1942, and it is especially appropriate to reflect on his views and many outstanding contributions to agricultural and resource economics.Interestingly, in a long and productive career, Wehrwein's finest contribution may have been one for which he is least known; he was advisor on land economics to the great ecologist Aldo Leopold.His mutually beneficial association with Leopold and related work provide sound guidance to us even in 1995, as economists continue to grapple with America's vexing environmental issues and choices.Leopold's writings, especially A Sand County ALmanac (1949), shape much of the philosophy of the modern environmental movement.He and Wehrwein were faculty colleagues at the University of Wisconsin from 1933, when Leopold was appointed professor of game (later wi ldlife) management in the department of agricultural economics, until Wehlwein's death.Wehrwein was notably helpful to him regarding "the economics of land reform, soil erosion, and rural taxation, " according to Leopold biographer Curt Meine.Reflecting th e Wehrwein influence, Leopold's writings contain the caution: "Conservation is paved with good intention which prove to be futile, or eve n dangero us, because they are devoid of critical understanding either of the land, or of economic land-use."Wehrwein observed
Novel endophytic lineages of <i>Tolypocladium</i> provide new insights into the ecology and evolution of <i>Cordyceps</i> -like fungi (2014)

The objective of this study was to identify a group of unknown endophytic fungal isolates from the living sapwood of wild and planted Hevea (rubber tree) populations. Three novel lineages of Tolypocladium are described based on molecular and morphological data. Findings from this study open a window for novel hypotheses regarding the ecology and role of endophytes within plant communities as well as trait evolution and potential forces driving diversification of Cordyceps-like fungi. This study stresses the importance of integrating asexual and sexual fungal states for a more complete understanding of the natural history of this diverse group. In addition, it highlights the study of fungi in the sapwood of tropical trees as habitat for the discovery of novel fungal lineages and substrate associations.
The effect of granulocyte-macrophage colony-stimulating factor on myeloid cells and its clinical applications (1995)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. Clinical applications of GM-CSF include ameliorating chemotherapy-induced neutropenia and enhancing hematopoietic recovery after bone marrow transplantation. This review evaluates the effect of GM-CSF on myeloid cells and its clinical applications.
Lateral internal sphincterotomy in the treatment of hemorrhoids (1986)

Using a microtip pressure transducer, anorectal manometry was performed in 119 patients with symptomatic hemorrhoids. In 96 patients (80.7 percent), a high anal pressure (greater than 125 cm/H2O) was found. These patients were treated by lateral internal sphincterotomy, carried out under local anesthesia. In 23 patients (19.3 percent), a normal or low anal pressure (less than 125 cm/H2O) was found. These patients were treated by band ligation or hemorrhoidectomy. The clinical results after lateral internal sphincterotomy (success rate, 75.3 percent) suggest that this procedure is a good alternative in selected patients.
Threat modeling for virtual directory services (2009)

Directory services are corporate computing objects responsible for providing information about user accounts, computer accounts, contacts, etc. Virtual directories are powerful tools for consolidating this data, modifying it if necessary, and presenting it to the end user in a highly customized manner. While attacks against directory services have been identified, attacks and vulnerabilities of virtual directories remain largely unstudied. In this paper, we present an analysis of four types of attacks on virtual directory services. In doing so, we describe how each is performed, and discuss how to detect and prevent each type of attack. This first step towards protecting virtual directory services is critical to protecting the information contained in the source directories - information which could potentially contain sensitive data and be used for authentication and/or access control decisions.
Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells. (1992)

Erythropoietin is the major regulator of the proliferation and differentiation of erythroid precursors, but little is known about its molecular mechanism of action. Using a human erythroleukemic cell line (HEL), we investigated whether p21ras is involved in erythropoietin signal transduction. We found that stimulation of HEL cells with erythropoietin induces a 5-fold increase in the amount of GTP bound to the endogenous p21ras. This effect is dose-dependent and occurs very rapidly. We also observed that erythropoietin causes tyrosine phosphorylation of several proteins in a time-dependent manner that correlates with the p21ras activation. Moreover, inhibition of tyrosine kinases by genistein totally prevents the erythropoietin-induced accumulation of a p21ras.GTP complex. By using an antiserum against the GTPase-activating protein, we found that p120GAP is rapidly phosphorylated in tyrosine in response to erythropoietin. Furthermore, the ability of a lysate from erythropoietin-stimulated HEL cells to induce in vitro hydrolysis of GTP bound to p21ras was strongly reduced. These results demonstrate that activation of p21ras is an early event in the erythropoietin signal transduction pathway, and they suggest that accumulation of the p21ras.GTP complex may be triggered by inhibition of GTPase-activating protein activity.
Academic Press dictionary of science and technology : CD-ROM version 1.0 (1996)

This CD-ROM version of the Academic Press Dictionary of Science and Technology enables quick searching of more than 13,000 entries. It covers 124 fields, from acoustics to zoology, with each field introduced with a brief essay by a scientist and labelled fields of application provided for each term. Hundreds of mathematical equations and chemical structures are presented, and appendices include: the periodic table; a chronology of modern science and technology; standard weights and measures; geological eras and classification of plants and animals. Other features include: existing terms updated and new terms added; 100 new 4-colour illustrations and hundreds of black-and-white illustrations; and applicable illustrations linked to relative terms. Expanded captions define illustrations to save time, and usage notes provide correct scientific writing and can be consulted independently or accessed from key terms. Searches can be limited to specific subject areas. and Harbrace College Handbook.
Cómo y por qué el mundo cambió las redes sociales (2019)

Why We Post es un proyecto de investigacion global y comparativo sobre los usos y efectos de las redes sociales coordinado por Daniel Miller desde University College London. Nueve antropologos realizaron quince meses de trabajo de campo en Brasil, Chile, China, Inglaterra, India, Italia, Trinidad y Turquia. Este proyecto global permitio explorar el impacto de las redes sociales en politica, en cuestiones de genero, en el acceso a la educacion y en el comercio. ?Cuales son las consecuencias del creciente enfasis en comunicacion visual en las redes sociales? ?Nos estamos volviendo mas individualistas o mas sociables? ?Por que se observa tanta ideologia conservadora en las redes sociales? ?Por que la igualdad online no es suficiente ara modificar la desigualdad offline? ?Como fue que los memes se volvieron instrumentos de vigilancia moral en internet? El proyecto Why We Post muestra que la unica forma de poder apreciar y entender algo tan omnipresente como las redes sociales es simplemente sumergirse en la vida cotidiana de la gente que publica contenido en tales redes. Solo asi podremos entender como la gente ha transformado las redes sociales en modos tan diversos e inesperados a lo largo y ancho del mundo, y podremos vislumbrar las consecuencias de esos cambios.
Endovascular treatment of post-traumatic complex carotid-cavernous fistulas, using the arterial approach. (1992)

Endoarterial embolization is now the treatment of choice for traumatic carotid-cavernous fistulas. However, traumatic or surgical occlusion of the carotid artery, or special cases such as unilateral double carotid-cavernous fistula, can make the transarterial approach hazardous or impossible. In such cases transvenous embolization can be an alternative treatment, although it is sometimes difficult or impossible to perform. Three cases of direct traumatic carotid-cavernous fistula and their treatments are described. In the first case, unilateral double carotid-cavernous fistula was treated with detachable balloons. In the second case, the fistula had previously been treated by trapping; percutaneous angioplasty was performed with subsequent plastic embolization of the fistula. In the third case, transarterial and transvenous approaches were impossible, and the patient was cured by combining a surgical procedure and an interventional technique.
Decreased membrane-bound ATP-hydrolytic activity in psoriatic epidermis* (1974)

Journal Article Decreased membrane‐bound ATP‐hydrolytic activity in psoriatic epidermis Get access G. MAHRLE, G. MAHRLE Department of Dermatology, University of Cologne, Germany †Reprint requests to: Dr G. Mahrle, University Skin Clinic, 5 Köln‐Lindenthal, West Germany. Search for other works by this author on: Oxford Academic Google Scholar C. E. ORFANOS C. E. ORFANOS Department of Dermatology, University of Cologne, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue 5, 1 November 1974, Pages 529–540, https://doi.org/10.1111/j.1365-2133.1974.tb12941.x Published: 01 November 1974 Article history Accepted: 21 March 1974 Published: 01 November 1974
The tensile strength of coal (1956)

Apparatus is described which has been developed for the measurement of the tensile strength of coal by bending thin strips. Measurements on four coals show that the strength depends on the type of coal and on the direction of loading relative to the bedding planes.
Introducción al estudio de los hermanos Modesto y Damián Pastor y la escultura religiosa de su tiempo (2003)

This study aimed to verify whether the approaching time (the time taken to reach the target point from another point, a short distance apart, during point-to-point movement in endoscopic surgery), assessed using the Hiroshima University Endoscopic Surgical Assessment Device (HUESAD), could distinguish the skill level of surgeons. Expert surgeons (who had performed more than 50 endoscopic surgeries) and novice surgeons (who had no experience in performing endoscopic surgery) were tested using the HUESAD. The approaching time, total time, and intermediate time (total time--approaching time) were measured and analyzed using the trajectory of the tip of the instrument. The approaching time and total time were significantly shorter in the expert group than in the novice group (p < 0.0001). The intermediate time did not significantly differ between the groups (p > 0.05). The approaching time, which is a component of the total time, is very mportant in the measurement of the total time to assess endoscopic surgical skills. Further, the approaching time was useful for skill assessment by the HUESAD for evaluating the skill of surgeons performing endoscopic surgery.
EPTC: Pre-emergence herbicide aids establishment of clovers in dryland pastures (1962)

EPTC can aid in the establishment of seeded annual clovers in dryland pastures where a weedy annual grass problem exists. Trials conducted in Mendocino, Mariposa, San Benito and Santa Barbara counties indicate that the pre-emergence herbicide will reduce competition from annual grasses but not from forbs such as mustard and filaree. Success is still dependent on climate, fertilizer treatment, grazing use and other related factors. EPTC application provides a method of altering species composition of a pasture. It can be applied in the late summer to prevent seed germination, in contrast to many herbicides that must be applied to living plants.