gebhart/patrepeval huggingface dataset:
The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis (2013)

High mobility group box chromosomal protein 1 (HMGB1) is a ubiquitous highly conserved single polypeptide in all mammal eukaryotic cells. HMGB1 exists mainly within the nucleus and acts as a DNA chaperone. When passively released from necrotic cells or actively secreted into the extracellular milieu in response to appropriate signal stimulation, HMGB1 binds to related cell signal transduction receptors, such as RAGE, TLR2, TLR4 and TLR9, and becomes a proinflammatory cytokine that participates in the development and progression of many diseases, such as arthritis, acute lung injury, graft rejection immune response, ischaemia reperfusion injury and autoimmune liver damage. Only a small amount of HMGB1 release occurs during apoptosis, which undergoes oxidative modification on Cys106 and delivers tolerogenic signals to suppress immune activity. This review focuses on the important role of HMGB1 in the pathogenesis of RA, mainly manifested as the aberrant expression of HMGB1 in the serum, SF and synovial tissues; overexpression of signal transduction receptors; abnormal regulation of osteoclastogenesis and bone remodelling leading to the destruction of cartilage and bones. Intervention with HMGB1 may ameliorate the pathogenic conditions and attenuate disease progression of RA. Therefore administration of an HMGB1 inhibitor may represent a promising clinical approach for the treatment of RA.
Ultraschallsensoren auf der Basis piezoelektrischer Polymere/ Ultrasonic sensors based on piezoelectric polymers (1989)

Article Ultraschallsensoren auf der Basis piezoelektrischer Polymere/ Ultrasonic sensors based on piezoelectric polymers was published on December 1, 1989 in the journal tm - Technisches Messen (volume 56, issue JG).
Enteric co-innervation of striated muscle fibers in the esophagus: Just a ?hangover?? (2001)

Striated muscle of the esophagus was until recently considered to consist of "classical" skeletal muscle fibers innervated by cholinergic vagal motoneurons. The recently described co-innervation originating from enteric neurons expressing nNOS, VIP, NPY, and galanin added a new dimension of complexity. The aim of this study was to summarize current knowledge about, and to get further hints as to the possible function of enteric co-innervation of striated esophageal muscle fibers. Aldehyde fixed rat esophagi were processed for immunocytochemistry for CGRP or VAChT (to demonstrate vagal motor terminals), nNOS/NADPH-d, VIP, NPY, and galanin (to demonstrate enteric terminals), met-enkephalin, mu opiate receptor, muscarinic receptors m1-3, soluble guanylyl cyclase, and cGMP dependent kinase type I and II. Motor endplates were visualized using fluorochrome tagged alpha-bungarotoxin to label nicotinic receptors, or with AChE histochemistry. Besides light and confocal laser scanning microscopy, immuno electron microscopy was also employed. Up to 80% of motor endplates were co-innervated. In addition to nNOS, VIP, NPY, and galanin, many enteric terminals in esophageal motor endplates expressed met-enkephalin. Some appeared to stain for the muscarinic m(2) receptor. There was prominent immunostaining for the micro opioid receptor in the sarcolemma at both junctional and extrajunctional sites. Immunostaining for soluble guanylyl cyclase was prominent immediately beneath the clusters of nicotinic receptors. Enteric varicosities and vagal terminals intermingled in motor endplates often without intervening teloglial processes. During ontogeny, initially high co-innervation rates were reduced to adult levels in a cranio-caudally progressing manner. We conclude that, in addition to a possible nitrergic, VIP-, NPY-, and galaninergic modulation of neuromuscular transmission by enteric neurons, opioidergic mechanisms could play a role. On the other hand, cholinergic influence on enteric neurons may be exerted also by the nucleus ambiguus via motor endplates, in addition to the input from the dorsal motor nucleus. The observations that enteric nerve fibers contact striated muscle fibers at specialized sites, i.e., motor endplates, and that these contacts appear in an ordered cranio-caudal sequence after cholinergic motor endplates have been established point to a specific function in neuronal control of esophageal muscle rather than to be an unspecific "hangover" from the smooth muscle past of this organ.
Inhibitory Effect of [Tyr34]bPTH-(7&ndash;34)-Amide on bPTH-(l-34) Ability to Reduce Uterine Contraction (1989)

Synthetic bovine parathyroid hormone containing the 1-34 NH2-terminal amino acids [bPTH-(1-34)] inhibits uterine contraction stimulated by a variety of agonists. Previously, we reported that the parathyroid hormone analogue [Nle8, Nle18, Tyr34]bPTH-(3-34)amide [NTA-(3-34)] antagonized this effect of bPTH-(1-34) while the analogue [Tyr34]bPTH-(7-34)amide [bPTH-(7-34)] used in this study stimulated uterine contraction. However, contrary to this previous report, bPTH-(7-34) in the present study failed to initiate a contractile response and instead resulted in an inhibitory response to the bPTH-(1-34) effect on uterine contraction in a dose-related manner. The inhibitory response of bPTH-(7-34) was further confirmed by demonstrating that this preparation of bPTH-(7-34) was capable of blocking bPTH-(1-34)-stimulated adenylate cyclase activity on particulate fractions of osteoblast-like cells from neonatal mouse calvarial. These results are consistent with those in the literature for the antagonistic effect of the 7-34 PTH fragment.
SAR-GMTI enhanced with simultaneous monostatic and bistatic detections (2014)

S.989-992
Urokinase-derived peptides regulate vascular smooth muscle contraction in vitro and in vivo (2000)

We examined the effect of urokinase (uPA) and its fragments on vascular smooth muscle cell contraction. Single-chain uPA inhibits phenylepherine (PE) -induced contraction of rat aortic rings, whereas two-chain uPA exerts the opposite effect. Two independent epitopes mediating these opposing activities were identified. A6, a capped peptide corresponding to amino acids 136-143 (KPSSPPEE) of uPA, increased the EC(50) of PE-induced vascular contraction sevenfold by inhibiting the release of calcium from intracellular stores. A6 activity was abolished by deleting the carboxyl-terminal Glu or by mutating the Ser corresponding to position 138 in uPA to Glu. A single-chain uPA variant lacking amino acids 136-143 did not induce vasorelaxation. A second epitope within the kringle of uPA potentiated PE-induced vasoconstriction. This epitope was exposed when single-chain uPA was converted to a two-chain molecule by plasmin. The isolated uPA kringle augmented vasoconstriction, whereas uPA variant lacking the kringle had no procontractile activity. These studies reveal previously undescribed vasoactive domains within urokinase and its naturally derived fragments.
Bioinoculants (2013)

This study aimed to find out the effect of plant growth-promoting rhizobacteria (PGPR; Azospirillum brasilense and Azotobacter vinelandii) either alone or in combination with different doses of nitrogen and phosphate fertilizers on growth, seed yield, and oil quality of Brassica carinata (L.) cv. Peela Raya. PGPR were applied as seed inoculation at 10(6) cells/mL(-1) so that the number of bacterial cells per seed was 2.6 × 10(5) cells/seed. The chemical fertilizers, namely, urea and diammonium phosphate (DAP) were applied in different doses (full dose (urea 160 kg ha(-1) + DAP 180 kg ha(-1)), half dose (urea 80 kg ha(-1) + DAP 90 kg ha(-1)), and quarter dose (urea 40 kg ha(-1) + DAP 45 kg ha(-1)). The chemical fertilizers at full and half dose significantly increased the chlorophyll, carotenoids, and protein content of leaves and the seed yield (in kilogram per hectare) but had no effect on the oil content of seed. The erucic acid (C22:1) content present in the seed was increased. Azospirillum performed better than Azotobacter and its effect was at par with full dose of chemical fertilizers (CFF) for pigments and protein content of leaves when inoculated in the presence of half dose of chemical fertilizers (SPH). The seed yield and seed size were greater. Supplementing Azospirillum with SPH assisted Azospirillum to augment the growth and yield, reduced the erucic acid (C22:1) and glucosinolates contents, and increased the unsaturation in seed oil. It is inferred that A. brasilense could be applied as an efficient bioinoculant for enhancing the growth, seed yield, and oil quality of Ethiopian mustard at low fertilizer costs and sustainable ways.
RBAC+: Dynamic Access Control for RBAC-Administered Web-Based Databases (2010)

In a clear contrast with the phenomenal growth of Web database applications, access control issues related to data stored in the back-end databases have largely been neglected. Current approaches to access control on databases do not fit web databases because they are mostly based on individual user identities. In this paper, we propose (RBAC <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> ), a dynamic access control model to enforce fine-grained access control to web databases. It extends the Role-Based Access Control model standard with the notions of application, application profile and sub-application session. The proposed dynamic access control model enhances the ability of detecting malicious transactions, the dominant cause that demolishes database system, by tracking application users throughout a whole session. Hence, attacks caused by malicious transactions can be detected and canceled timely before they succeed.
Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway. (1988)

Electrically permeabilized neutrophils were used to study the mechanism of activation of the respiratory burst by the chemotactic agent formyl-methionyl-leucyl-phenylalanine (fMLP). Permeabilization was assessed by flow cytometry, radioisotope trapping, and by the requirement for exogenous NADPH for oxygen consumption. A respiratory burst could be elicited by fMLP, phorbol ester, or diacylglycerol in permeabilized cells suspended in EGTA-buffered medium with 100 nM free Ca2+. The fMLP response persisted even in cells depleted of intracellular Ca2+ stores by pretreatment with ionomycin. Therefore, a change in cytosolic free Ca2+ ([Ca2+]i) is not required for receptor-mediated stimulation of the respiratory burst. The responses induced by phorbol ester and diacylglycerol were largely inhibited by H7, a protein kinase C antagonist. In contrast, the stimulation of oxygen consumption by fMLP was unaffected by H7. These results suggest that a third signaling pathway, distinct from changes in [Ca2+]i and activation of protein kinase C, is involved in the response of neutrophils to chemoattractants.
Septic shock in children (1990)

In a retrospective analysis of 2110 admissions to the pediatric intensive care unit, 564 cases of septic shock were identified (26.7% of the total admissions). Septic shock was defined in patients with: (1) clinical evidence of sepsis; (2) fever (greater than 38.3 degrees C) or hypothermia (less than 35.6 degrees C); (3) tachycardia; (4) tachypnea; and (5) inadequate organ perfusion. Inadequate perfusion was defined as hypotension or evidence of peripheral hypoperfusion (poor capillary refill or cyanosis with hypoxemia, oliguria, acidosis or altered mentation). Inotropic support was required to maintain an adequate blood pressure and perfusion in 268 of 564 patients (47.5%). Septic shock with confirmed bacterial infection occurred in 143 patients (143 of 564, 25.2%); these cases were caused by Haemophilus influenzae, type b (59 of 143, 41.3%), Neisseria meningitidis (26 of 143, 18.2%) and Streptococcus pneumoniae (16 of 143, 11.2%). Eight of 564 (1.4%) cases of septic shock were not clinically apparent on initial evaluation and were diagnosed within 24 hours after admission to the hospital. We conclude that septic shock occurs more frequently in children than previously appreciated and may develop after admission to the hospital.
A multi-agent based scheduling algorithm for adaptive electric vehicles charging (2016)

This paper presents a decentralized scheduling algorithm for electric vehicles charging. The charging control model follows the architecture of a Multi-Agent System (MAS). The MAS consists of an Electric Vehicle (EV)/Distributed Generation (DG) aggregator agent and “Responsive” or “Unresponsive” EV agents. The EV/DG aggregator agent is responsible to maximize the aggregator’s profit by designing the appropriate virtual pricing policy according to accurate power demand and generation forecasts. “Responsive” EV agents are the ones that respond rationally to the virtual pricing signals, whereas “Unresponsive” EV agents define their charging schedule regardless the virtual cost. The performance of the control model is experimentally demonstrated through different case studies at the micro-grid laboratory of the National Technical University of Athens (NTUA) using Real Time Digital Simulator. The results highlighted the adaptive behaviour of “Responsive” EV agents and proved their ability to charge preferentially from renewable energy sources.
Cloud detection of remote sensing images by deep learning (2016)

Cloud detection plays a major role for remote sensing image processing. Most of the existed cloud detection methods use the low-level feature of the cloud, which often cause error result especially for thin cloud and complex scene. In this paper, a novel cloud detection method based on deep learning framework is proposed. The designed deep Convolutional Neural Networks (CNNs) consists of four convolutional layers and two fully-connected layers, which can mine the deep features of cloud. The image is firstly clustered into superpixels as sub-region through simple linear iterative cluster (SLIC) method. Through the designed network model, the probability of each superpixel that belongs to cloud region is predicted, so that the cloud probability map of the image is generated. Lastly, the cloud region is obtained according to the gradient of the cloud map. Through the proposed method, both thin cloud and thick cloud can be detected well, and the result is insensitive to complex scene. Experimental results indicate that the proposed method is more robust and effective than compared methods.
Excitation Systems for Small Industrial and Commercial Generators (1962)

The factors influencing the increasing usage of static voltage regulators and exciters on small generators are discussed in this paper. System performance specifications are defined. Various excitation and regulating systems are described and illustrated, and their performance compared and evaluated.
The Honeymoon... Reverie to Reality (1957)

As the prospective bride changes from a starry-eyed Miss to a realistic Mrs., honeymoon plans change to fit a new, mature outlook on life.
DEDIP: a user-friendly environment for digital image processing algorithm development (2002)

The DEDIP (developmental environment for digital image processing) system is a simple environment for the development of digital image processing applications. It consists of two user interface levels. The low level is compiled software library of digital image processing and system management functions. The high level is a command line interpreter with a set of digital image processing and file management tools. A graphical user interface (GUI) has been developed to increase the user-friendliness of DEDIP at the high level. The GUI is based on the DEDIP functions and the X-window systems. The user has access to all levels and can develop, test, and implement in software digital image processing applications easily. Structured software design techniques of modularity and data encapsulation have been applied in the development of DEDIP.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hypotensive Agents. III.<sup>1</sup> Dialkylaminoalkyl Pyrrolidine Derivatives<sup>2a,b</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHypotensive Agents. III.1 Dialkylaminoalkyl Pyrrolidine Derivatives2a,bLeonard M. Rice, Charles H. Grogan, and E. Emmet ReidCite this: J. Am. Chem. Soc. 1953, 75, 9, 2261–2262Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/ja01105a515https://doi.org/10.1021/ja01105a515research-articleACS PublicationsRequest reuse permissionsArticle Views245Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deep desulfurization of transportation fuels by characteristic reaction resided in adsorbents (2009)

Abstract A method for deep desulfurization of transportation fuels was presented. Reactive conversion of sulfur compounds and the following adsorption occurred inside adsorbents. The condensation reaction with formaldehyde catalyzed by phosphomolybdic acid was shown effective for the removal of thiophenic and benzothiophenic compounds. Thiophene or benzothiophene of model fuels was completely removed. Coupling with an oxidation reaction, the total sulfur content of commercial fuels was dropped to below 15 ppm. Appropriate desulfur condition was at 70–80°C and ambient pressure without consumption of hydrogen. Saturated adsorbent was regenerated with heating in air at 400°C, and the sulfur capacity was almost fully recovered. Fuel quality was not negatively affected by the desulfur operation. © 2009 American Institute of Chemical Engineers AIChE J, 2009
Quelques considérations sur les rapports du Canada français avec l'impérialisme britannique au XIXe siècle (1981)

Several factors attracted French Canadians to overseas service in the 19th-century British Empire: a military tradition going back to the French régime: the lure of adventure: and Quebec's conservative-religious dominant ideology, which encouraged sympathy for the imperialist notion of the civilising mission. Seen as champions of Christianity, protectors of the weak, and guardians of order, colonial empires were good things. Between the 1850s and the 1880s the British Empire was generally represented in Quebec not only as protector of Christian civilisation but also as defender of French Canada's distinct nationality, against both American annexation- ism and English-Canadian assimilationism. British tolerance was contrasted with English-Canadian fanaticism, and the empire portrayed as an association of nationalities, each contributing in its own fashion to a common cause.This image changed after the Riel affair, as English-Canadian nationalism pressed for assimilation of French Canada, seizing on imperialism as a pretext for doing so. Claims that French Canadians were disloyal, demands that they speak English' because they were British subjects, insistence that they serve the empire on English Canada's terms, turned Britain into a symbol of bullying assimilationism and made French Canadians hostile to further imperial service.
Preparation and properties of the Mo2X4(PMe3)4 compounds with X = NCS and NCO (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and properties of the Mo2X4(PMe3)4 compounds with X = NCS and NCOF. Albert Cotton and Marek MatuszCite this: Inorg. Chem. 1988, 27, 12, 2127–2131Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ic00285a023https://doi.org/10.1021/ic00285a023research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Gas phase oxidation of alcohols to aldehydes or ketones catalysed by supported gold (2003)

Primary and secondary aliphatic alcohols are smoothly oxidised by air to the corresponding carbonyl derivatives with high selectivity using 1% Au on silica.
Simultaneous determination of penicillin G and its major metabolites in blood using ultra performance liquid chromatography-tandem mass spectrometry (2013)

A fast method for the quantitative determination of penicillin G (PEN G) , penicilloic acid and penilloic acid in blood with ultra performance liquid chromatography-electrospray tandem mass spectrometry was developed. A simple deproteinization of the blood was used with a mixed solution of acetonitrile and water (4:1, v/v) as extraction solvent. The blood extract was directly injected onto an LC column. The chromatographic separation of the components was performed on a BEH C18 column (50 mm x 2.1 mm, 1.7 microm) using acetonitrile and water containing 0.1% formic acid. The mass spectrometer was operated in positive electrospray ion mode. Finally, the analysis was carried out with multiple reaction monitoring (MRM) mode. The limits of detection (LODs) for these three compounds were in the range of 0.1 to 2.0 ng/mL and the limits of quantification (LOQs) in the range of 0.5 to 5.0 ng/mL. Within the linear range, the correlation coefficients (r) of PEN G and its metabolites were all more than 0.9974. Accuracies for these targeted compounds were ranged from 92.3% to 105.5%, and the within-day precisions were less than 10%. The stabilities of the components were evaluated in the temperature range from 18 to 80 degrees C, and the mass concentration of penicillin G was decreased significantly with the extensions of storage temperature and storage time. Biological samples of the rats medicated with PEN G were analyzed using the developed method. The results show that PEN G can just be detected at 0.5 h after administration. However, the detection time limitation of penicilloic acid can be extended to 36 h. The established method has been further expanded for the applicability of forensic identification, and has a reference value for the detection of penicillin G residue in food.