gebhart/patrepeval huggingface dataset:
Induction of metamorphosis in<i>Hermissenda crassicornis</i>larvae (Molluscs: Nudibranchia) by GABA, choline and serotonin (1996)

Summary The nudibranch mollusc Hermissenda crassicornis is currently used as a biomedical model in neurobiological studies. It possesses planktotrophic larvae which metamorphose in the laboratory in the presence of the hydroid Tubularia crocea in yields of about 2–5% (Tamse et al., 1990). This study presents evidence that artificial metamorphic inducers such as GABA (γ-aminobutyric acid), choline, and serotonin (alone or combined with the natural inducer T. crocea), can be used to improve the metamorphic success in H. crassicornis larvae. GABA at 10−5M and 10−4M, choline at 10−3M and 10−4M, and serotonin at 10−5 M and 10−4M, were most effective, while serotonin at 10−3 M was toxic. Larvae 47 and 63 days old metamorphosed at different rates when exposed to the same concentrations of chemicals, but these had no positive effect on young larvae, i.e., 28 and 39 days old. On the other hand, when young larvae were exposed to the natural inducer, an habituation phenomenon was observed, i.e., the larvae did not metamorphose. Exposing the larvae to the natural inducer after larval day 47 improved the metamorphic yield by about 100%. These results indicate that the optimum larval age for inducing metamorphosis in H. crassicornis is older than previously considered.
ChemInform Abstract: Enantioselective Synthesis of 3‐Substituted Indolines by Asymmetric Intramolecular Carbolithiation in the Presence of (‐)‐Sparteine. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
C-terminal Trimerization, but Not N-terminal Trimerization, of the Reovirus Cell Attachment Protein Is a Posttranslational and Hsp70/ATP-dependent Process (1996)

The C-terminal globular head of the lollipop-shaped final sigma1 protein of reovirus is responsible for interaction with the host cell receptor. Like the N-terminal fibrous tail, it has its own trimerization domain. Whereas N-terminal trimerization (formation of a triple alpha-helical coiled coil) occurs at the level of polysomes (i.e. cotranslationally) and is ATP-independent, C-terminal trimerization is a posttranslational event that requires ATP. Coprecipitation experiments using anti-Hsp70 antibodies and truncated final sigma1 proteins synthesized in vitro revealed that only regions downstream of the N-terminal alpha-helical coiled coil were associated with Hsp70. Hsp70 was also found to be associated with nascent final sigma1 chains on polysomes as well as with immature postribosomal final sigma1 trimers (hydra-like intermediates with assembled N termini and unassembled C termini). These latter structures were true intermediates in the final sigma1 biogenetic pathway since they could be chased into mature final sigma1 trimers with the release of Hsp70. Thus, unlike N-terminal trimerization, C-terminal trimerization is Hsp70- and ATP-dependent. The involvement of two mechanistically distinct oligomerization events for the same molecule, one cotranslational and one posttranslational, may represent a common approach to the generation of oligomeric proteins in the cytosol.
Dynamic simulation of legged robots using a physics engine (2014)

This article presents an application for dynamic simulation of legged robots based on a physics engine. In the presented application an iterative solver is supported by analytical equations of the dynamics and software modules for collision detection, environment modeling and visualization. The presented application of the simulator allows for development and verification of control algorithms before their implementation on the real robot.
Multi-waveform radar for ice sheet measurements and classroom demonstration (2007)

The Center for Remote Sensing of Ice Sheets (CReSIS), at the University of Kansas, is a Science and Technology Center established by the National Science Foundation (NSF) in 2005, with the mission of developing new technologies and computer models to measure and predict the response of sea level change to the mass balance of ice sheets in Greenland and Antarctica. As part of a senior undergraduate capstone design course we designed and simulated a wideband, push-broom, multi-waveform radar for fine-resolution airborne ice sheet surface elevation measurements. A prototype of this system was developed and its response was measured. The prototype will serve as a teaching tool and a design platform for the final instrumentation package to be used on an uncrewed aerial vehicle (UAV) being developed at the University of Kansas. In this paper we will present the objectives of the project, design details, simulation results, and testing results from experiments delay line and point targets.
High-Frequency Electromechanical Imaging of Ferroelectrics in a Liquid (2012)

The coupling between electri- cal and mechanical phenomena is a ubiqui- tous feature of many information and energy storage materials and devices. In addition to involvement in performance and degradation mechanisms, electromechanical effects un- derpin a broad spectrum of nanoscale ima- gingandspectroscopiesincludingpiezoresponseforceandelectrochemicalstrainmicroscopies. Traditionally, these studies are conducted under ambient conditions. However, applications related to imaging energy storage and electrophysiological phenomena require operation in a liquid phase and therefore the development of electromechanical probing techniques suitable to liquid environments. Due to the relative high conductivity of most liquids and liquid decomposition at low voltages, the transfer of characterization techniques from ambient to liquidisnotstraightforward.Herewepresentadetailedstudyofferroelectricdomainimaging and manipulation in thin film BiFeO3 using piezoresponse force microscopy in liquid environments as model systems for electromechanical phenomena in general. We explore the use of contact resonance enhancement and the application of multifrequency excitation and detection principles to overcome the experimental problems introduced by a liquid environment. Understanding electromechanical sample characterization in liquid is a key aspect not only for ferroelectric oxides but also for biological and electrochemical sample systems.
Teamwork in Cyberspace: Using TEAMCORE to Make Agents Team-Ready (1999)

In complex, dynamic and uncertain environments extending from disaster rescue missions, to future battlefields, to monitoring and surveillance tasks, to virtual training environments, to future robotic space missions,
Abstract 18036: Exosomes From Human CD34+ Cells Mediate Angiogenic Effects in vitro and in vivo (2010)

In preclinical studies and early phase clinical trials, CD34+ cells have been shown to induce neovascularization in ischemic tissue, improving perfusion and function. Several reports have suggested...
A single‐panel LCoS engine based on light guides (2006)

Abstract— By using light‐guide components, a new scrolling‐color engine for single‐panel LCoS projection has been developed. Light guides allow for loss‐less delivery of light leading to a simpler and more‐compact system. Engine design and construction based on a single 0.88‐in.‐diagonal LCoS panel is described. Separate results with a multilayer optical film Cartesian PBS show that a significant improvement in system efficiency is possible.
Structure of human osteonectin based upon analysis of cDNA and genomic sequences (1989)

Overlapping human bone osteonectin cDNAs were obtained by screening two independent human SaOS-2 lambda gt11 libraries using antibovine osteonectin monoclonal antibodies. One clone contains a 0.54-kb insert and the other a 1.9-kb insert. Insertion fragments from lambda clones were liberated by restriction digestion and subcloned into pUC19 for sequencing. Digestion of the 1.9-kb insert with EcoRI released 0.4- and 1.5-kb fragments. Sequencing analysis revealed that the 0.54- and 0.4-kb fragments are identical except for 150 nucleotides missing at the 5' region of the 0.4-kb fragment. The composite nucleotide sequence of human osteonectin has a total length of 2091 nucleotides and is comprised of 50 nucleotides of 5'-noncoding sequence, a coding segment for 303 amino acids, a termination codon, and 1114 nucleotides of 3'-noncoding sequence. The primary transcript codes for 286 amino acids of mature protein and a 17-residue amino-terminal hydrophobic signal peptide. Outstanding properties inferred from the primary structure are putative Ca2+ binding domains located in the glutamic acid rich NH2 terminus (residues 1-52) and two "EF"-hand domains in the C-terminal half of the protein (residues 165-176 and 257-286). The mature protein also contains a cysteine-rich, highly hydrophilic region homologous to the ovomucoid serine protease inhibitors (residues 76-132). Overlapping human genomic clones in lambda EMBL3 for osteonectin have been isolated and characterized. Intron/exon junction sequencing of the human osteonectin gene shows the presence of 10 exons and 9 introns. The mature protein is encoded by nine exons separated by eight introns.(ABSTRACT TRUNCATED AT 250 WORDS)
A Design of Dual-Tree Complex Wavelet Transform Based on Least Squares Method (2009)

In this paper, a novel design of dual-tree complex wavelet transform based on least squares method is proposed. An effective design method based on allpass filter with FIR has proposed by Selesnick. However, this method holds two problems. First, optimal frequency characteristic cannot be realized due to the restriction of design parameters. Second, approximation of the half sample delay condition is restricted on low frequency. The proposed method can achieve the high design degrees of freedom by using least squares method. It is shown that the method can design more effective dual-tree complex wavelet transform than conventional one, in terms of sharpness of frequency characteristic and accuracy of half sample delay condition, directionality and shift-invariance, by simulations. In the end of this paper, the performance of DTCWT designed by the proposed method for practical application, image denoising, is demonstrated. The proposed method outperforms the conventional method.
Protection and Polymerization of Functional Monomers. 25. Synthesis of Well-Defined Polystyrene Bearing a Triol Functionality by Means of Anionic Living Polymerization of 4-[(4-(4-Vinylphenyl)butoxy)methyl]-1-methyl-2,6,7- trioxabicyclo[2.2.2]octane (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProtection and Polymerization of Functional Monomers. 25. Synthesis of Well-Defined Polystyrene Bearing a Triol Functionality by Means of Anionic Living Polymerization of 4-[(4-(4-Vinylphenyl)butoxy)methyl]-1-methyl-2,6,7- trioxabicyclo[2.2.2]octaneTakashi Ishizone, Takashi Tominaga, Kiyoaki Kitamura, Akira Hirao, and Seiichi NakahamaCite this: Macromolecules 1995, 28, 14, 4829–4836Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ma00118a008https://doi.org/10.1021/ma00118a008research-articleACS PublicationsRequest reuse permissionsArticle Views288Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases (1998)

Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. These inhibitory agents activate mitogen activated protein kinases (MAPKs), and thus the role of MAPKs in the mechanism of inhibition of Stat3 activation was investigated. Inhibition of IL-6-induced Stat3 activation by PMA and ionomycin was rapid (within 5 min) and did not require new RNA or protein synthesis. Inhibition of Stat3 DNA-binding activity and tyrosine phosphorylation by PMA, ionomycin, and granulocyte/macrophage-colony-stimulating factor was reversed when activation of the extracellular signal-regulated kinase (ERK) group of MAPKs was blocked by using specific kinase inhibitors. Expression of constitutively active MEK1, the kinase that activates ERKs, or overexpression of ERK2, but not JNK1, inhibited Stat3 activation. Inhibition of Stat3 correlated with suppression of IL-6-induction of a signal transducer and activator of transcription (STAT)-dependent reporter gene. In contrast to IL-6, activation of Stat3 by interferon-alpha was not inhibited. MEKs and ERKs inhibited IL-6 activation of Stat3 harboring a mutation at serine-727, the major site for serine phosphorylation, similar to inhibition of wild-type Stat3, and inhibited Janus kinases Jak1 and Jak2 upstream of Stat3 in the Jak-STAT-signaling pathway. These results demonstrate an ERK-mediated mechanism for inhibiting IL-6-induced Jak-STAT signaling that is rapid and inducible, and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway. This inhibitory pathway provides a molecular mechanism for the antagonism of Stat3-mediated IL-6 activity by factors that activate ERKs.
Rhodium Derivatives of Peroxoboronic Acids and Peroxoboric Acid: Formation of Metallatrioxaborolanes from an η<sup>2</sup>‐Peroxo Complex (2008)

Heterocyclische Peroxide mit fünfgliedrigen RhOOBO-Ringen werden bei den Reaktionen eines Rhodiumperoxokomplexes mit Phenylboronsäurederivaten erhalten. Die Produkte können als Rhodiumderivate von Perborsäure (siehe Schema) und Phenylperboronsäuren betrachtet werden.
Laparoscopy for Definite Localization and Simultaneous Treatment of Ectopic Ureter Draining a Dysplastic Kidney in Children (2002)

For patients having a clinical suspicion of ectopic ureter draining a dysplastic kidney, laparoscopy may represent an alternative modality for simultaneous diagnosis and treatment.
Inherent interference‐filter polymer light‐emitting diodes (1997)

A global or “systems” approach to the design of polymer‐based light‐emitting devices is shown to be important for an understanding of the details of light emission from these devices. A self‐interference‐filter type of light‐emitting device with a very narrow spectral output–a prerequires for many applications but difficult to realize because of the typically broad electroluminescence emission spectrum–is described, in which color selection is achieved by the appropriate combination of layer thickness and values of refractive index of the components of the device structure.
Multiple-input all-optical logic gates utilizing polarization properties of non-degenerate four-wave mixing (2001)

We present experimental results on how the polarization properties of non-degenerate four-wave mixing can be used in advanced all-optical logic gates. The technique enables 3-bit logic operations without cascading nonlinear elements. These gates may be suitable for logic operations in an opto-electrical front-end, which moves some of the necessary computation of data to the optical domain, both after transmission and before detection. A 3-bit ADDER is demonstrated, and scalability to circuits with more inputs are discussed.
Design and Fabrication of a Robotic Arm for Material Handling (2005)

The commercial robots are expensive for use in the educational institutions. The operation of them will not leave room for experimentation, which is necessary in an educational institution. Further a large number of components that can be used for building a robot are readily available in the market. Hence this project has been taken up to allow us to build a working robot using as many of the off the shelf components to provide the necessary flexibility. This would make it a low cost robot with enough flexibility for the students to experiment the various functions of the robot.The mechanical component of the manipulator was built with three degrees of freedom, one revolute and two prismatic joints. This configuration is most common to be used as a material-handling device for machine tools. The revolute joint was achieved by making use of a pneumatic rotary table and one prismatic joint is realized by means of a pneumatic cylinder. The second prismatic joint in the Z-direction is achieved by the use of an AC servomotor with a ball screw and linear motion elements to provide for accurate positioning capability. The gripper had been designed for cylindrical components, since this robot was conceived as a material handling unit for a CNC turning center. All the necessary design calculations had been done and the finite element analysis was carried out for the main structure. The control system of the robot was one of the crucial elements. A PC is used as a controller. The motion control was carried out with the help of a motion control card DC2-PC100. It had the ability to control 2 servo and 2 stepper motors in addition to other digital and analogue controls. Several types of sensors and actuators were used for the robot to be fully automatic. The signal conditioning circuitry was designed in house for the interfacing between sensors, actuators and controllers. The control algorithm was developed with the necessary functioning to coordinate all the joint movement as well as gripper manipulation.
Hybrid controller synthesis for idle speed management of an automotive engine (2000)

The specification for the idle control problem for automotive engines is to maintain the crankshaft speed within a given range in the presence of load changes. A cycle-detailed hybrid model of the engine that captures well the interactions between the discrete phenomena of torque generation and spark ignition, and the continuous evolution of the power-train and air dynamics, is proposed. The maximal robust-controlled invariant set that satisfies the specification is determined and the maximal controller for the engine in idle is presented.
Awareness of the Bicycle Helmet Law in North Carolina (2007)

The majority ofparents, teachers, physicians, and EMS personnel in Pitt County, North Carolina, are aware of the mandatory bicycle helmet law for children. Enforcement of and education about the bicycle helmet law should be increased .
AMOS - An Architecture for Active Mediators (1993)

AMOS (Active Mediators Object System) is an architecture to model, locate, search, combine, update, and monitor data in information systems with many work stations connected using fast communication networks. The approach is called active mediators, since it introduces an intermediate level of `mediator&apos; software between data sources and their use in applications and by users, and since it supports &apos;active &apos; database facilities. A central part of AMOS is an Object-Oriented (OO) query language with OO abstractions and declarative queries. The language is extensible to allow for easy integration with other systems. This allows for knowledge, now hidden within application programs as local data structures, to be extracted and stored in AMOS modules. A distributed AMOS architecture is being developed where several AMOS servers communicate, and where queries in a multi-database language are allowed to refer to several AMOS databases or other data sources. An overview is made of ...
Superinfection as a driver of genomic diversification in antigenically variant pathogens (2008)

A new pathogen strain can penetrate an immune host population only if it can escape immunity generated against the original strain. This model is best understood with influenza viruses, in which genetic drift creates antigenically distinct strains that can spread through host populations despite the presence of immunity against previous strains. Whether this selection model for new strains applies to complex pathogens responsible for endemic persistent infections, such as anaplasmosis, relapsing fever, and sleeping sickness, remains untested. These complex pathogens undergo rapid within-host antigenic variation by using sets of chromosomally encoded variants. Consequently, immunity is developed against a large repertoire of variants, dramatically changing the scope of genetic change needed for a new strain to evade existing immunity and establish coexisting infection, termed strain superinfection. Here, we show that the diversity in the alleles encoding antigenic variants between strains of a highly antigenically variant pathogen was equal to the diversity within strains, reflecting equivalent selection for variants to overcome immunity at the host population level as within an individual host. This diversity among strains resulted in expression of nonoverlapping variants that allowed a new strain to evade immunity and establish superinfection. Furthermore, we demonstrated that a single distinct allele allows strain superinfection. These results indicate that there is strong selective pressure to increase the diversity of the variant repertoire beyond what is needed for persistence within an individual host and provide an explanation, competition at the host population level, for the large genomic commitment to variant gene families in persistent pathogens.
4026 Characteristics of the Flow around a Circular Cylinder with Tangential Blowing near the Plane Boundary (2006)

The flow around a circular cylinder, which is placed near a rigid plane boundary, with tangential blowing is investigated experimentally under the condition of Re=2.7×10^4. The Flow visualization and velocity measurements were carried out for various momentum coefficient Cμ and clearances between the circular cylinder and the rigid plane boundary. The results of experiment show that the reverse flow patterns are classified into two cases, one being the reverse flow occurring periodically, and the other occurring steadily. For the case of the reverse flow occurring periodically, the characteristics of the lift force can be represented by a new nominal jet momentum coefficient Cμ'.