gebhart/patrepeval huggingface dataset:
Effect of 1D Infiltration Assumption on Stability of Spatially Variable Slope (2011)

Rainfall-induced landslides are often analyzed using the infinite slope model, in which each slice of the slope is treated as a soil column subjected to one-dimensional, vertical infiltration. This one-dimensional (1D) assumption means that slope inclination and lateral downslope flow of water are ignored. Some studies have shown that the impact of lateral flow on slope stability is not significant. Hence, 1D infiltration analysis is sufficient to analyze rainfall-induced landslides. However, those studies are based on homogeneous soils, i.e. soil spatial variability is not considered in the analysis. This paper investigates the significance of slope inclination and lateral flow on the stability of an infinite slope with spatially varying soil in the depth direction. Only the saturated hydraulic conductivity of the soil is assumed to be spatially varying in the form of a stationary lognormal random field. It was found that the impact of the inclination on the pressure head and the factor of safety is not significant. However, the impact on the probability of slope failure is significant for some examples studied in this paper.
Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical and early clinical development (2020)

Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the epilepsy community to appraise the latest data on new antiepileptic drugs and emergency seizure treatments, including, in recent years, updates on progress with the development of novel monitoring and therapeutic devices. Because of the COVID-19 pandemic, the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV) was held as a fully virtual conference on July 27-30, 2020 for the sessions on drugs and on August 3, 2020 for the sessions on devices, and was attended during the 5 days by >500 participants from 63 countries. This progress report summarizes key preclinical and initial (phase 1) clinical data on eight investigational treatments that are currently in early development, including 2-deoxy-D-glucose, GAO-3-02, JNJ-40411813, NBI-921352, NTX-001, sec-butylpropylacetamide, XEN1101, and XEN496. This report provides an overview of current scenarios in the area of treatment discovery and development. The information presented illustrates a variety of innovative strategies, including exploration of compounds with novel mechanisms of action, transplantation of interneurons into epileptogenic brain regions, and the targeting of rare, previously neglected syndromes.
Reaction of hydrogen with metallic and reduced halides. The requirement of delocalized electrons for reaction (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of hydrogen with metallic and reduced halides. The requirement of delocalized electrons for reactionArthur W. Struss and John D. CorbettCite this: Inorg. Chem. 1978, 17, 4, 965–969Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://pubs.acs.org/doi/10.1021/ic50182a034https://doi.org/10.1021/ic50182a034research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ionic Hydrogenation of Alkynes by HOTf and Cp(CO)3WH (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIonic Hydrogenation of Alkynes by HOTf and Cp(CO)3WHLi Luan, Jeong-Sup Song, and R. Morris BullockCite this: J. Org. Chem. 1995, 60, 22, 7170–7176Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/jo00127a023https://doi.org/10.1021/jo00127a023research-articleACS PublicationsRequest reuse permissionsArticle Views488Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Side reactions of monoaminodicarboxylic acids in peptide synthesis (1988)

N ‐benzyloxycarbonyl‐ l ‐homoglutamine was studied to answer the question whether or not there is any tendency for the dehydration of the δ‐carboxamide group during activation and coupling. Only a minor conversion to nitrile by‐products was found in the activation of the α‐carboxyl group and formation of peptide bond with the help of dicyclohexylcarbodiimide. Addition of N ‐hydroxybenzotriazole to the reacting mixture eliminates the side chain dehydration reaction. The dehydration reaction is also overcome by protection of the side chain carboxamide with the benzyloxycarbonylcarbamoyl substituent.
New Cross Section Data for the 10B(dn0)11C Reaction Below 160 keV. (2016)

Abstract not provided.
Analysis of the regional air passenger transport system in Brazil: some aspects of its evolution and diagnosis (2010)

Passenger air transport in Brazil, as elsewhere in the world, has been undergoing substantial changes in recent years, not only because of external factors, but also as a consequence of several important changes in the regulatory framework.This paper focuses on the regional aspects of airline passenger traffic in Brazil, based on a review of the literature and interviews with some key government authorities.We first provide an overview of the country's regions and sketch out the historical evolution of regional air transportation in the country.We then discuss the recent changes affecting the sector, considering the regulatory and operational factors at play, particularly in relation to the network of Brazilian cities served by air transport.
Novel mutations of the HOXD13 gene in hand and foot malformations. (2008)

Homeobox genes encode a set of transcription factors of fundamental importance for body patterning during embryogenesis. Hoxa9-a13 and Hoxd9-d13 play an especially important part in vertebrate limb development. Synpolydactyly (SPD) is characterized by various malformations of the limbs. The expansion of the polyalanine tract in 1OXD13 is one of its major causes. Recently, there have been many analysis studies of HOXD13 in patients with SPD and limb malformations. We analyzed HOXD13 in 100 patients with limb malformations, which affects the limbs in the distal parts of the metacarpal and/or metatarsal bones. Seven mutations in the coding region and two mutations in the 5'-untranslated region were identified. All were novel mutations. In this study, the mutations were located upstream in the homeobox. Thus, translation of the homeobox was affected by upstream mutations. Consequently, this suggested the possibility that abnormalities in the hands and feet could be caused by novel HOXD13 gene mutations.
Steroids. XXI.<sup>1</sup> Δ<sup>7</sup>-Androstene-3β,17β-diol (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroids. XXI.1 Δ7-Androstene-3β,17β-diolF. Neumann, G. Rosenkranz, J. Romo, and Carl DjerassiCite this: J. Am. Chem. Soc. 1951, 73, 11, 5478–5480Publication Date (Print):November 1, 1951Publication History Published online1 May 2002Published inissue 1 November 1951https://doi.org/10.1021/ja01155a546RIGHTS & PERMISSIONSArticle Views47Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (408 KB) Get e-Alerts Get e-Alerts
CRYOPOROMETRY: A NEW NMR METHOD FOR CHARACTERISING POROUS MEDIA (1994)

Abstract A new method to determine pore dimensions in the mesopore range is described. NMR is used to quantify the melting point depression of an absorbed liquid and hence determine pore size distributions in various silica samples. Results are shown to compare well with conventional gas desorption determinations and ultimate resolution considered. The method is relatively simple, rapid and non-destructive. The damage to pore structures caused by ice formation is demonstrated using the technique.
Protocol-directed weaning: a process of continuous performance improvement. (2005)

The use of a nursing-directed and/or respiratory therapist-directed protocol in many intensive care units for weaning from mechanical ventilation is associated with a shorter duration of ventilation and length of stay in the ICU. Most protocols have two formal components: the daily screening of a set of simple observations or interventions to identify readiness to proceed, followed by a spontaneous breathing trial that tests the patient's ability to breathe independently. The daily screen is designed to identify potential barriers regarding medical stability, level of consciousness, oxygenation, ventilation, and airway patency and protection. However, one must avoid selecting criteria that are too restrictive, potentially delaying the discontinuation of ventilation.
Beta‐adrenoceptor blockade delays granulation tissue formation in polyurethane sponge implants (2009)

Blockade of beta1- and beta2-adrenoceptors, but not alpha-adrenoceptors, impairs granulation tissue development in PU implants due to interference with the inflammatory response.
Serological constancy of the cell wall of Pyricularia oryzae. (1978)

Several studies have been reported on the classification of pyricularia oryzae races. B) Recently, in our laboratory, a biochemical approach on this line has been done on the basis of cellulase activities secreted from P. oryzae. 9 ) During the investigation of cell wall polysaccharide of P. oryzae, we have found an antigenic polysaccharide on the cell surface of P. oryzae. 'O ) We considered that this antigenecity of the cell wall of P. oryzae might be a probe for the specific recognition on the various races of this rice blast fungus. The presence of antigenic polysaccharide on the cell wall of microorganisms is well known. Particularly, bacterial lipopolysaccharide O-antigen) and yeast mannans12) are well characterized. Usually cell surface antigens are species specific.13) However, it is not clear whether the cell surface antigenecity is different from race to race in one species. Recently, Fukazawa et af. l4) have investigated on Candida sake using chemical and serological techniques and showed that C. sake are devided into four groups. P. oryzae is tentatively classified into three groups (races), namely N, C, and T according to their pathogenecities for rice plants. N group has a pathogenic specificity for Japonica varieties, C group is pathogenic to Chinese rice varieties and T group is specific for foreign varieties other than Chinese; for instance, Indica varieties 1 .) In addition to the above three races, nonpathogenic strains are also isolated and classified into 0 group.15) In this communication, we describe the serological relationship among those races of P. oryzae. The strains of P. oryzae used in this study were representative strains of each of four races, namely, T-I (Ken 53-33), C-l (THU 62-132), N-l (H 373), 0 (THU 65--Dl). All strains were grown at 28°C for 3 days on the Vogel N-yeast extract medium.) To obtain antibody against P. oryzae cells, male albinorabbits weigh• mg approximately over 2.5 kg each were immunized by the intramascular injection of acetone-dried P. oryzae cells with Freund's complete adjuvant'7) three * Present address: Chugai Pharmaceutical Co., Ltd. ' =>. 2400 Ul l0 a:: tl.300 a l1J I« t:200 tl. u l1J 0: tl. IOO
A Role for E2F Activities in Determining the Fate of Myc-Induced Lymphomagenesis (2009)

The phenotypic heterogeneity that characterizes human cancers reflects the enormous genetic complexity of the oncogenic process. This complexity can also be seen in mouse models where it is frequently observed that in addition to the initiating genetic alteration, the resulting tumor harbors additional, somatically acquired mutations that affect the tumor phenotype. To investigate the role of genetic interactions in the development of tumors, we have made use of the Emu-myc model of pre-B and B cell lymphoma. Since various studies point to a functional interaction between Myc and the Rb/E2F pathway, we have investigated the role of E2F activities in the process of Myc-induced lymphomagenesis. Whereas the absence of E2F1 and E2F3 function has no impact on Myc-mediated tumor development, the absence of E2F2 substantially accelerates the time of tumor onset. Conversely, tumor development is delayed by the absence of E2F4. The enhanced early onset of tumors seen in the absence of E2F2 coincides with an expansion of immature B lineage cells that are likely to be the target for Myc oncogenesis. In contrast, the absence of E2F4 mutes the response of the lineage to Myc and there is no expansion of immature B lineage cells. We also find that distinct types of tumors emerge from the Emu-myc mice, distinguished by different patterns of gene expression, and that the relative proportions of these tumor types are affected by the absence of either E2F2 or E2F4. From these results, we conclude that there are several populations of tumors that arise from the Emu-myc model, reflecting distinct populations of cells that are susceptible to Myc-mediated oncogenesis and that the proportion of these cell populations is affected by the presence or absence of E2F activities.
Consciousness as a Physical Process Caused by the Organization of Energy in the Brain (2018)

To explain consciousness as a physical process we must acknowledge the role of energy in the brain. Energetic activity is fundamental to all physical processes and causally drives biological behavior. Recent neuroscientific evidence can be interpreted in a way that suggests consciousness is a product of the organization of energetic activity in the brain. The nature of energy itself, though, remains largely mysterious, and we do not fully understand how it contributes to brain function or consciousness. According to the principle outlined here, energy, along with forces and work, can be described as actualized differences of motion and tension. By observing physical systems, we can infer there is something it is like to undergo actualized difference from the intrinsic perspective of the system. Consciousness occurs because there is something it is like, intrinsically, to undergo a certain organization of actualized differences in the brain.
LiveTraVeL: Real-time matching of transit vehicle trajectories to transit routes at scale (2019)

We present LiveTraVeL (Live Transit Vehicle Labeling), a real-time system to label a stream of noisy observations of transit vehicle trajectories with the transit routes they are serving (e.g., northbound bus #5). In order to scale efficiently to large transit networks, our system first retrieves a small set of candidate routes from a geometrically indexed data structure, then applies a fine-grained scoring step to choose the best match. Given that real-time data remains unavailable for the majority of the world's transit agencies, these inferences can help feed a real-time map of a transit system's trips, infer transit trip delays in real time, or measure and correct noisy transit tracking data. This system can run on vehicle observations from a variety of sources that don't attach route information to vehicle observations, such as public imagery streams or user-contributed transit vehicle sightings.We abstract away the specifics of the sensing system and demonstrate the effectiveness of our system on a "semisynthetic" dataset of all New York City buses, where we simulate sensed trajectories by starting with fully labeled vehicle trajectories reported via the GTFS-Realtime protocol, removing the transit route IDs, and perturbing locations with synthetic noise. Using just the geometric shapes of the trajectories, we demonstrate that our system converges on the correct route ID within a few minutes, even after a vehicle switches from serving one trip to the next.
Anticandida Agents from a Tanzanian Plant <i>Albizia anthelmintica</i> (2015)

Abstract Candidiasis is one of the most frequent opportunistic infections in individuals with severe immunosupression and further development of resistance against the available antifungal drugs has created an alarming situation. This requires intensive drug discovery to develop new, more effective, affordable and accessible antifungal agents possessing novel modes of action. Albizia anthelmintica , which is ethno medically used to treat vaginal candidiasis in the Morogoro and coastal regions of Tanzania, on activity guided fractionation and subsequent purification resulted in the isolation and characterization of an isomer of methyl cyclitol ( 1 ) and six echinocystic acid saponins ( 2 – 7 ). Saponins 6 and 7 are new and being reported for the first time from nature. Among all the isolated compounds, 3‐O‐[α‐L‐arabinopyranosyl (1→2)][α‐L‐arabinopyranosyl (1→6)]‐2‐acetamido‐2‐deoxy‐β‐D‐glucopyranosyl echinocystic acid ( 4 ), 3‐O‐[α‐L‐arabinopyranosyl (1→2)] [α‐L‐arabinopyranosyl (1→6)]‐2‐amino‐2‐deoxy‐β‐D‐glucopyranosyl echinocystic acid ( 6 ) and 3‐O‐[β‐D‐glucopyranosyl (1→3)] [α‐L‐arabinopyranosyl (1→2)] [α‐L‐arabinopyranosyl (1→6)]‐2‐amino‐2‐deoxy‐β‐D‐glucopyranosyl echinocystic acid ( 7 ) and their combinations were active against the various strains of C. albicans with MICs ranging from 12.5 to 125 μg/ml.
Methicillin-Resistant<i>Staphylococcus aureus</i> (2013)

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Synthetic Fluids for High Capacity Traction Drives (1970)

A series of fluids having coefficients of traction in rolling contact devices higher by 30% or more than those of the best previously available oils have been developed. These fluids have good oxidation stability in the 300–350 F range, are compatible with standard engineering materials and have viscosity characteristics suitable for industrial or vehicular applications. The screening test methods used for determination of coefficient of traction in the development of these fluids are described.
Cell-mediated immune response to chlamydia in anterior uveitis: role of HLA B27. (1983)

The relationship between HLA B27 anterior uveitis (AU) and evidence of chlamydia trachomatis infection was investigated in 35 consecutive patients attending a uveitis research clinic, using a complement fixation test and lymphocyte transformation test to chlamydia (ornithosis-psittacosis) group antigen. A significant stimulation index (SI greater than 2) was found in 73% (11/15) of the HLA B27 positive patients compared with the HLA B27 negative AU patients and controls (P less than 0.03). There was no difference between AU patients with and without associated rheumatic disease or in terms of antibody response. The results of the present study indicate a significant relationship between the cell-mediated immune response to chlamydia group antigen and the HLA B27 positive subgroup of patients with AU.
Implementing scalable disk-less clusters using the Network File System (NFS). (2003)

This paper describes a methodology for implementing disk-less cluster systems using the Network File System (NFS) that scales to thousands of nodes. This method has been successfully deployed and is currently in use on several production systems at Sandia National Labs. This paper will outline our methodology and implementation, discuss hardware and software considerations in detail and present cluster configurations with performance numbers for various management operations like booting.
An overview and history of interpersonal psychotherapy (2009)

Interpersonal psychotherapy is regarded as an effective psychotherapy particularly in the treatment of depression and has been around for more than 20 years. However, there is a paucity of information and discussion in the nursing literature. This article provides an overview of interpersonal psychotherapy, including its origins and historical background. This is followed by a description of the model and its application in patients with major depression.