gebhart/patrepeval huggingface dataset:
The chemical synthesis of proteins (Solid phase peptide synthesis) (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe chemical synthesis of proteins (Solid phase peptide synthesis)M. L. Peck and V. J. Hruby Cite this: J. Chem. Educ. 1972, 49, 9, 652Publication Date (Print):September 1, 1972Publication History Received3 August 2009Published online1 September 1972Published inissue 1 September 1972https://doi.org/10.1021/ed049p652.2RIGHTS & PERMISSIONSArticle Views215Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (862 KB) Get e-Alerts Get e-Alerts
Perioperative Management for Transplant of Autologous Adrenal Medulla to the Brain for Parkinsonism (1988)

N 2 O, perfusion de sufentanil et vecuronium avec de faibles concentrations disoflurane procurent une anesthesie suffisante
Synthesis, CoMFA Analysis, and Receptor Docking of 3,5-Diacyl-2,4-Dialkylpyridine Derivatives as Selective A<sub>3</sub> Adenosine Receptor Antagonists (1999)

3,5-Diacyl-2,4-dialkyl-6-phenylpyridine derivatives have been found to be selective antagonists at both human and rat A3 adenosine receptors (Li et al. J. Med. Chem. 1998, 41, 3186-3201). In the present study, ring-constrained, fluoro, hydroxy, and other derivatives in this series have been synthesized and tested for affinity at adenosine receptors in radioligand binding assays. Ki values at recombinant human and rat A3 adenosine receptors were determined using [125I]AB-MECA (N6-(4-amino-3-iodobenzyl)-5'-N-methylcarbamoyladenosine). Selectivity for A3 adenosine receptors was determined vs radioligand binding at rat brain A1 and A2A receptors, and structure-activity relationships at various positions of the pyridine ring (the 3- and 5-acyl substituents and the 2- and 4-alkyl substituents) were probed. At the 5-position inclusion of a beta-fluoroethyl (7) or a gamma-fluoropropyl ester (26) was favorable for human A3 receptor affinity, resulting in Ki values of 4.2 and 9.7 nM, respectively, while the pentafluoropropyl analogue was clearly less potent at human A3 receptors. At the 2-, 3-, and 4-positions, fluoro or hydroxy substitution failed to enhance potency and selectivity at human A3 receptors. Several analogues were nearly equipotent at rat and human A3 receptors. To further define the pharmacophore conformationally, a lactam, a lactone, and thiolactones were tested in adenosine receptor binding. The most potent analogue in this group was compound 34, in which a thiolactone was formed between 3- and 4-positions and which had a Ki value of 248 nM at human A3 receptors. Using affinity data and a general pharmacophore model for A3 adenosine receptor antagonists recently proposed, we applied comparative molecular field analysis (CoMFA) to obtain a three-dimensional quantitative structure-activity relationship for pyridine derivatives, having good predictability (r2pred = 0.873) for compounds in the test set. A rhodopsin-based model of the human A3 receptor was built, and the pyridine reference ligand 2,3,4, 5-tetraethyl-6-phenyl-pyridine-3-thiocarboxylate-5-carboxylate (MRS 1476) was docked in the putative ligand binding site. Interactions between receptor transmembrane domains and the steric and the electrostatic contour plots obtained from the CoMFA analysis were analyzed.
ChemInform Abstract: Intramolecular Diels ‐ Alder Reaction with Furan‐diene. (1986)

Abstract Total Synthesis of (±)‐11‐Ketotestosterone and (±)‐Adrenosterone.
Numerical study on static component generation from the primary Lamb waves propagating in a plate with nonlinearity (2018)

Under the discipline of nonlinear ultrasonics, in addition to second harmonic generation, static component generation is another frequently used nonlinear ultrasonic behavior in non-destructive testing (NDT) and structural health monitoring (SHM) communities. However, most previous studies on static component generation are mainly based on using longitudinal waves. It is desirable to extend static component generation from primary longitudinal waves to primary Lamb waves. In this paper, static component generation from the primary Lamb waves is studied. Two major issues are numerically investigated. First, the mode of static displacement component generated from different primary Lamb wave modes is identified. Second, cumulative effect of static displacement component from different primary Lamb wave modes is also discussed. Our study results show that the static component wave packets generated from the primary S0, A0 and S1 modes share the almost same group velocity equal to the phase velocity of S0 mode tending to zero frequency cplate. The finding indicates that whether the primary mode is S0, A0 or S1, the static components generated from these primary modes always share the nature of S0 mode. This conclusion is also verified by the displacement filed of these static components that the horizontal displacement field is almost uniform and the vertical displacement filed is antisymmetric across the thickness of the plate. The uniform distribution of horizontal displacement filed enables the static component, regardless of the primary Lamb modes, to be a promising technique for evaluating microstructural damages buried in the interior of a structure. Our study also illustrates that the static components are cumulative regardless of whether the phase velocity of the primary and secondary waves is matched or not. This observation indicates that the static component overcomes the limitations of the traditional nonlinear Lamb waves satisfying phase velocity matching condition to achieve cumulative second harmonic generation. This nature also enables the primary Lamb waves excited at a low center frequency to generate static component used for inspecting large-scale structures with micro-scale damages.
Nucleosides with 5{prime}-O-photolabile protecting groups (1996)

Nucleosides are described with photolabile protecting groups on the 5{prime}-hydroxyl. These nucleosides are useful in the synthesis of nucleic acids on solid-state arrays. 11 figs.
Usefulness of the Nutrient Foramen of Lamina for Insertion of Thoracic Pedicle Screws (2008)

The nutrient artery foramen on the lamina of thoracic vertebrae is useful for inserting the thoracic pedicle screw.
Synthesis of New N-Alkyl- and N-Acyldioxinophenothiazine and Acridinone Derivatives (2000)

The synthesis of new substituted dioxino[b]-and [c]phenothiazines or acridinones is reported.N-Arylation of [1,4]benzodioxin-6-amine with organolead or organobismuth reagents gave N-aryl-2,3-dihydro-1,4-benzodioxin-6-amine; subsequent Bernthsen thionation led to phenothiazine ring formation, followed by N-acylation.On the other hand [1,4]benzodioxin-6-amine was first N-alkylated and the resulting alkylamines were N-phenylated before Bernthsen thionation to provide the tetracyclic phenothiazines.Alternative arylation with chlorobenzoic acid followed by cyclization under acidic conditions afforded the dioxinoacridinones, which were successfully alkylated.
[Estimation of the teratogenic effects of therapeutic drugs]. (1980)

Therapeutics may induce embryological abnormalities in the laboratory animal, Now, it is known from experience that the currently applied experimental procedures allow to detect potential teratogenic risks in animals. There is only a slight possibility that a new therapeutic would be highly teratogenic as very special conditions are fundamental for the exteriorisation of the teratogenic effect, such as the sensibility and the developmental stage of the embryo, its genetic constitution and the physiology and pathology of the mother. The wellknown difficulties associated with the extrapolation of experimental results require that more species are used and that historical control data for each species and strains are kept allowing a global assessment of the results which better weighs the potential risk against the therapeutic activity of each new therapeutic.
Properties of Black Matpe Globulin. (1997)

1) ブラックマッペグロブリンは, 沈降係数8Sのタンパク質からなり, 11Sタンパク質は, アルカリ性でゲル濾過を行ったときのみ認められたことから, 本来存在するタンパク質ではなく, 8S成分が解離会合して生成したものと推察される。2) 8Sグロブリンは糖タンパク質であり, 2.5%のマンノースと, 0.047%のグルコサミンを含んでいた。3) 8SグロブリンはSDSにより分子量55,000, 45,000, 33,000の3種類のサブユニットに解離したが, これらの結合にS-S結合は関与していないことが推察された。
Firmware: v1.4.0 Release Candidate 1 (2016)

This is a first early release candidate for v1.4.0
Connectors in Very-High-Speed Digital Circuits (1973)

The properties of standard card edge, printed circuit, and flat cable connectors have been investigated from the point of view of transmitting pulses with very short rise times. A simple theory based on linear approximation of the leading and trailing edges of the actual pulse waveform is derived to predict the effect of impedance mismatch caused by the connector. Experimental confirmation of the theory, measurements of popular types of connectors, and extrapolation of experience with a 350-Mb/s logic network confirm that, under certain conditions, the currently available connectors can be used with pulse rise times longer than 250 ps and with interconnection impedances from 50 to 100 ohms. Transmission lines matched at both ends and/or balanced pairs are preferred for interconnections between different parts of a very fast (greater than 250-Mb/s) pulse system.
Widely Tunable Parametric Amplification and Pulse Train Generation by Heating a Photonic Crystal Fiber (2011)

We describe a simple technique that allows for the achievement of widely tunable parametric generation in a photonic crystal fiber. This is achieved by heating the fiber and using a specific phase-matching condition in the normal dispersion regime which is highly sensitive to temperature. Experimental results show a sideband tunability of about 17 THz in the 800 nm and 1550 nm spectral bands by heating the fiber from room temperature to 500 , leading to a tuning rate of 34 . By adding a small tunable continuous-wave seed together with the pulsed pump, we further show the generation of sub-nanosecond pulses tunable around 800 nm through parametric amplification.
I (2008)

<sc>Strether couldn’t</sc> have said he had during the previous hours definitely expected it; yet when, later on, that morning—though no later indeed than for his coming forth at ten o’clock—he saw the concierge produce, on his approach, a <italic>petit bleu</italic> delivered since...
Heterogeneity of Trichomonas vaginalis and discrimination among trichomonal isolates and subpopulations with sera of patients and experimentally infected mice (1985)

The antibody response in trichomoniasis patients was examined with a variety of methodologies including enzyme-linked immunosorbent assays, indirect immunofluorescence, immunoblotting, and radioimmunoprecipitation-electrophoresis-autoradiography. Based on enzyme-linked immunosorbent assay recognition of trichomonal isolates, sera from patients with trichomoniasis were categorized into reactive class I (IA, IB, and IC) and nonreactive class II sera. A diminished ability to precipitate antibody-binding trichomonad membrane proteins by the whole cell radioimmunoprecipitation assay was noted from class IA to class II sera. The antigenic distinctions among various Trichomonas vaginalis isolates appeared due to high-molecular-weight protein antigens detected by class IA sera in a whole cell radioimmunoprecipitation assay. The heterogeneity in antigenic patterns was confirmed among the isolates with sera from experimental animals. Also, live T. vaginalis cells appear to have only a few of the entire repertoire of major immunogenic surface proteins accessible to antibody binding. Immunoblotting demonstrated that the high-molecular-weight proteins responsible for trichomonal isolate heterogeneity are present in all isolates. The data suggest that trichomonads of a given isolate express only a subset of internally synthesized protein antigens on their surface. Importantly, the presence of these protein antigens on T. vaginalis membranes correlated with antibody production in subcutaneously challenged mice. Finally, indirect immunofluorescence studies with highly reactive, pooled sera from either patients or mice revealed a subpopulation of nonstaining trichomonads. These data support the view that heterogeneity among T. vaginalis is dependent upon the surface disposition of highly immunogenic protein antigens. Strategies may now be developed not only for studying potential vaccine reagents, but also for examining possible antigenic phenotypic variations in this experimental model.
ChemInform Abstract: Synthesis of Chiral 3‐Substituted‐3‐aminomethylpyrrolidines and Related Compounds. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Error Correction Capability of Column-Weight-Three LDPC Codes Under the Gallager A Algorithm—Part II (2010)

The relation between the girth and the error correction capability of column-weight-three LDPC codes under the Gallager A algorithm is investigated. It is shown that a column-weight-three LDPC code with Tanner graph of girth <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</i> ¿ 10 can correct all error patterns with up to <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(g</i> /2-1) errors in at most <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</i> /2 iterations of the Gallager A algorithm. For codes with Tanner graphs of girth <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</i> ¿ 8, it is shown that girth alone cannot guarantee correction of all error patterns with up to <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(g</i> /2-1) errors under the Gallager A algorithm. Sufficient conditions to correct <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(g</i> /2-1) errors are then established by studying trapping sets.
Cyclic CO sub 2 injection for light oil recovery: Performance of a cost shared field test in Louisiana. Fifth quarterly report, November 22, 1989-February 21, 1990 (1990)

The ultimate objective of this research is to provide a base of knowledge on the CO{sub 2} huff n' puff process for the enhanced recovery of Louisiana crude oil. Project goals include laboratory corefloods to investigate several parameters important to the process, and numerical simulation to interpret coreflood results. Additional activities include construction and analysis of a field test data base to facilitate target reservoir screening, and to identify sensitive operational parameters. The information from laboratory corefloods and data base evaluations will be used in the design and implementation of a Department of Energy sponsored field test. The results of all laboratory and field evaluations will be made available to the industry through workshops, periodic reports, and meetings. 2 tabs.
Effect of maternal treatment with altrenogest on age at puberty, hormone concentrations, pituitary response to exogenous GnRH, oestrous cycle characteristics and fertility of fillies (1990)

Puberty was studied using 15 fillies of Quarter Horse phenotype. Fillies were from dams treated daily from Days 20 to 325 of gestation with: (1) 2 ml neobee oil per 50 kg body weight (controls); or (2) 2 ml altrenogest (2.2 mg/ml) per 50 kg body weight. The clitoris was measured at birth and approximately every 12 weeks until 84 weeks of age. Blood samples were collected from 9 fillies (5 treated, 4 controls) every 4 days over a 28-day period at 8-week intervals from 4 to 68 weeks of age; sampling continued every 4 days after 72 weeks of age until first oestrus. Blood samples were collected daily during oestrus (greater than or equal to 35 mm follicle) and on Days 4, 6, 10, and 14 after ovulation for the first 2 oestrous cycles. GnRH challenges (5 micrograms/kg) were administered every 8 weeks from 32 to 96 weeks of age. Puberty was defined as the first oestrus with ovulation. Beginning 1 February 1987, fillies were teased daily and their ovaries were examined by ultrasonography every 3 days (daily during oestrus). Fillies were inseminated with 500 x 10(6) motile spermatozoa from one stallion. Pregnancy was diagnosed by ultrasonography on Days 11, 12, 15 and every 5 days until Day 50 after ovulation. Prenatal altrenogest treatment caused clitoral enlargement (P less than 0.05) and increased serum concentrations of LH from 1 to 7 months of age. The amount of LH released in response to exogenous GnRH was greater (P less than 0.05) in treated fillies at 32, 64, and 72 weeks of age. Treated fillies had higher serum concentrations of FSH from 1 to 4 months (P less than 0.05), but FSH was lower (P less than 0.05) in treated fillies before and during first oestrus. Serum concentrations of LH and FSH peaked transiently at 10 months and LH was depressed from 64 to 88 weeks and began to rise 14 days before first oestrus. Concentrations of FSH began to decline 14 days before first oestrus. The median age at puberty was 90 weeks. Durations of oestrus, dioestrus, and the oestrous cycle were not different between groups and were similar to those for adult mares. First cycle pregnancy rates and overall rates were 100 and 82% and 100 and 91.7% for control and treated fillies, respectively (P greater than 0.05). Maternal treatment with altrenogest did alter gonadotrophin secretion before puberty, but had no effect on functional reproductive performance in fillies.
Perfusion MR Imaging of Brain Neoplasms (2000)

Perfusion MR Imaging of Brain NeoplasmsJimmie C. Wong1, James M. Provenzale and Jeffrey R. PetrellaAudio Available | Share
Run-time parallelization and scheduling of loops. Contract report (1988)

PROSPERO CRD42016034045.
Transient Response Enhancement on the Output-Capacitorless Low-Dropout Regulator Using the Multipath Nested Miller Compensation with a Transient Quiescent Current Booster (2011)

Low drop-out regulators (LDOs) are widely used in the system-on-a-chip (SoC) design. Due to the multi-function and energy saving requirements for mobile applications nowadays, more strict specifications are expected on the developmental roadmap of the LDOs. An output-capacitorless LDO providing fast transient response under the low supply voltage and low quiescent current conditions is proposed in this paper. Provided by the low supply voltage, the proposed LDO adopts cascading technique using the Multipath Nested Miller Compensation (MNMC) to maintain a higher bandwidth for fast transient requirement. In addition, a Transient Quiescent Current Booster (TQCB) is supplemented to the operational amplifier to improve the slew rate for the fast load transient. The TQCB only raises the quiescent current during the load transient instant so that both power saving and the load response improvement could be well achieved. It deserves noting that the proposed TQCB contains only two transistors, which is simple to be implemented compared to the other transient current enhancement techniques. The designed LDO has only 1.6pF capacitance for the totally added on-chip compensation, and 25.8µA of current consumption in the main amplifier. The recovery time under the fast load change is less than 3µs and the stability is guaranteed. Test results from the real implementation of a 0.35µm CMOS process verify that the designed LDO performs as expected.
Global collocation methods for approximation and the solution of partial differential equations (1986)

Polynomial interpolation methods are applied both to the approximation of functions and to the numerical solutions of hyperbolic and elliptic partial differential equations. The derivative matrix for a general sequence of the collocation points is constructed. The approximate derivative is then found by a matrix times vector multiply. The effects of several factors on the performance of these methods including the effect of different collocation points are then explored. The resolution of the schemes for both smooth functions and functions with steep gradients or discontinuities in some derivative are also studied. The accuracy when the gradients occur both near the center of the region and in the vicinity of the boundary is investigated. The importance of the aliasing limit on the resolution of the approximation is investigated in detail. Also examined is the effect of boundary treatment on the stability and accuracy of the scheme.
Gefitinib (“Iressa”, ZD1839), an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses Breast Cancer Resistance Protein/ABCG2–Mediated Drug Resistance (2005)

Gefitinib ("Iressa", ZD1839) is an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor, and the single agent is clinically effective in non-small cell lung cancer. Although gefitinib combined with various cytotoxic agents has been reported to enhance cytotoxicity in vitro and in mouse models, the mechanism remains undetermined. Here, to explore the mechanism with topoisomerase I inhibitors, we focused on the efflux pump of the breast cancer resistance protein (BCRP/ABCG2), and then examined whether gefitinib restored drug sensitivity in multidrug-resistant cancer cells overexpressing BCRP. We used PC-6 human small cell lung cancer cells and multidrug-resistant PC-6/SN2-5H cells selected with SN-38 of the active metabolite of irinotecan, and BCRP-overexpressing MCF-7/MX cells selected with mitoxantrone and BCRP cDNA transfectant MCF-7/clone 8 cells. Drug sensitivity against anticancer drugs was determined by tetrazolium dye assay, and intracellular topotecan accumulation by FACScan. The topotecan transport study was done using the plasma membrane vesicles of PC-6/SN2-5H cells. The resistant PC-6/SN2-5H cells overexpressed BCRP but not epidermal growth factor receptor mRNA. Ten micromoles of gefitinib reversed topotecan, SN-38, and mitoxantrone resistance, and increased the intracellular topotecan accumulation in the resistant cells but not in the parental cells. Furthermore, gefitinib inhibited the topotecan transport into the vesicles, and the K(i) value was 1.01 +/- 0.09 micromol/L in the Dixon plot analysis, indicating direct inhibition of BCRP by gefitinib. However, gefitinib was not transported into the vesicles with the high-performance liquid chromatography method. These results indicate that gefitinib reverses BCRP-mediated drug resistance by direct inhibition other than competitive inhibition as a BCRP substrate. Combination of gefitinib and topoisomerase I inhibitors could be clinically effective in cancers expressing BCRP.