gebhart/patrepeval huggingface dataset:
Deficient Activity of Mitochondrial Flavine Adenine Dinucleotide-Linked Glycerophosphate Dehydrogenase in Pancreatic Islet Beta Cells as a Determinant of Non-Insulin-Dependent Diabetes Mellitus (2018)

Extensive experimental investigations in animal models of diabetes mellitus have led to the proposal that a deficient activity of mitochondrial flavine adenine dinucleotide (FAD)-linked glycerophosphate dehydrogenase represents a far-from-uncommon, albeit not invariable, determinant of pancreatic islet B-cell insulin secretory dysfunction. The major aim of the present review is to summarize the results of these investigations and, hence, to encourage further work on the prevalence of this enzymatic defect in the islet B cell of human subjects, especially non-insulin-dependent diabetic patients. J Endocrinol Metab. 2018;8(2-3):16-26 doi: https://doi.org/10.14740/jem496w
Mutation in mammalian cells by isomers of 5-methylchrysene diolepoxide (1986)

The two pairs of diastereomeric anti- and syn-diolepoxide derivatives of 5-methylchrysene in both bay regions were tested for cytotoxicity and for mutagenicity at the hprt locus of chinese hamster V79 cells as determined by the ability of the cells to form colonies in medium containing 6-thioguanine. The concentration of compound in the cell media required to achieve 37% survival ranged from 0.3 to 4.5 micrograms/ml. Although the mutagenic effectiveness, i.e. the induced mutation frequency per unit concentration of compounds, varied over a 30-fold range, the mutagenic efficiency, i.e. the induced mutation frequency at an equivalent level of cell survival, showed only a 3-fold variation. The anti-1,2-diol-3,4-epoxide isomer (anti-5MCDE-I) was found to be the most mutagenic of the 5-methylchrysene diolepoxide isomers. This finding is consistent with previous observations on the tumorigenicity of these diolepoxides.
Study of Single-Event Transients in High-Speed Operational Amplifiers (2008)

This paper presents a simulation and experimental study of the analog single-event transient sensitivity of wide bandwidth operational amplifiers. Architecture effects are presented that could influence ASIC design and COTS selection.
Molecular Nature of Spontaneous Modifications in<i>gacS</i>Which Cause Colony Phase Variation in<i>Pseudomonas</i>sp. Strain PCL1171 (2005)

Pseudomonas sp. strain PCL1171 displays colony phase variation between opaque phase I and translucent phase II colonies, thereby regulating the production of secondary metabolites and exoenzymes. Complementation and sequence analysis of 26 phase II mutants and of 13 wild-type phase II sectors growing out of phase I colonies showed that in all these cases the phase II phenotype is caused by spontaneous mutations in gacA or/and gacS. Mutation of gac reduced both the length of the lag phase and the generation time. Isolation and sequencing of the gacS genes from the phase II bacteria revealed one insertion as well as several random point mutations, deletions, and DNA rearrangements. Most phase II colonies reverted with a high frequency, resulting in wild-type gacA and gacS genes and a phase I phenotype. Some phase II bacteria retained the phase II phenotype but changed genotypically as a result of (re)introduction of mutations in either gacA or gacS. The reversion of gacA or gacS to the wild type was not affected by mutation of recA and recB. We conclude that in Pseudomonas sp. strain PCL1171, mutations in gacA and gacS are the basis for phase variation from phase I to phase II colonies and that, since these mutations are efficiently removed, mutations in gac result in dynamic switches between the "wild-type" population and the subpopulations harboring spontaneous mutations in gacA and or gacS, thereby enabling both populations to be maintained.
Industrial Applications of Advanced Electrochemical Finishing Techniques (2004)

Faraday Technology, Inc. has developed electrochemical techniques for the edge and surface finishing of advanced materials, such as titanium alloys, stainless steels, and nickel based superalloys. This technology employs electrochemical metal removal under the influence of a bipolar, pulsed electric field to provide enhanced process control and excellent surface finishes. This process achieves high rates of metal removal in the presence of simple chemistries that are pH neutral, water based, non-toxic, and environmentally benign. This is in contrast to competing technologies that rely on electrolytes that are comprised of concentrated acids or ethylene glycol. This paper will present Faraday’s recent development efforts in a wide variety of industries, including the semiconductor, automotive, and medical industries.
Flow cytometric identification of intracellular antigens: detection of minimal residual leukemia. (1990)

Recent advances in preparation of cells for flow cytometric analysis have enabled the sensitive detection of intracellular antigens. We have examined the utility of two color flow cytometry for the detection of minimal residual T cell acute lymphoblastic leukemia (T-ALL) using a combination of expression of the pan-T cell marker CD5 and intranuclear terminal deoxynucleotidyl transferase (TdT). CD5+TdT+ cells can be sensitively detected above background in remission bone marrows (0.03% sensitivity). Possible extension of this technique to the detection of minimal residual B-lineage ALL, acute myelogenous leukemia (AML), and non-hematologic malignancies is discussed.
Lack of Inhibition of BBN-induced Bladder Carcinogenesis in C57BL/6 Mice by Intravesical Instillation of KRN 7000. (2003)

The immunostimulatory α-galactosylceramide, KRN 7000 or (2S, 3S, 4R)-1-0-(α-D-galactopyranosyl)-2-(N-hexacosnoylamino)-1,3,4-octadecatrienol, might be anticipated to have antitumor activity in vivo apart from any direct toxicity to cancer cells. We investigated inhibition of mouse bladder carcinogenesis by intravesically instillated KRN 7000. C57BL/6 mice were divided into 4 groups; all first receiving the carcinogen 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in drinking water for 8 weeks. Next, groups 1 and 2, respectively were administered 10 and 0.1 μg/kg of KRN 7000 intravesically once weekly for 17 weeks. Group 3 received only 0.3 ml of saline (vehicle control). Group 4 did not undergo bladder catheterization. By histologic examination at 26 weeks, the incidence of bladder carcinoma of all types tended to be higher in group 1 than in group 3, but without significance. The incidence of bladder carcinoma in group 4, (no catheterization), was similar to that in group 1. Only one precancerous lesion (papillary or nodular dysplasia) was seen in each of groups 3 and 4. Thus vesical instillation of KRN 7000 did not inhibit bladder carcinogenesis in mice, exposed to the carcinogen studied.
Effects of size structure on batch growth of lactic acid bacteria. (1987)

Effects of size distribution of lactic acid bacterium Lactobacillus bulgaricus on its growth were studied empirically by measuring time courses of population density, volume distribution function and concentrations of cell mass, substrate and acid in batch cultures. The size distribution function normalized with the average size and population density was preserved exclusively in the logarithmic phase and the stationary phase of cell mass growth. Statistical analysis further detailed the growth kinetics of L. bulgaricus, and the potentiality of size structure on population dynamics was incorporated into empirical equations.
Design and validity of a miniaturized open-field aberrometer (2012)

The new aberrometer gave valid, repeatable measurements of refractive error and HOAs over a large range. It can measure continuously, thus providing direct feedback on the optical status of the visual system to surgeons during intraocular lens implantation and corneal surgery.
DETERMINATION OF THE SIX TURBULENT REYNOLDS' STRESSES BY THE HOT WIRE METHOD FOR ARBITRARY TURBULENT INTENSITY AND GEOMETRY WITH SPECIAL APPLICATION TO AXISYMMETRIC FLOW (1961)

A relationship is derived between the mean square fluctuating current of a hot wire anemometer and the six turbulent Reynolds' stresses in the stream- coordinate system without employing the usual low turbulent intensity approximation. The relatively simple result is a consequence of assuming proportionality between the wire current reading and the perpendicular velocity component instead of the nonlinear dependence required by King's law. The assumption is valid for instruments equipped with the proper linearizing circuitry. Tbe stream-coordinate Reynolds' stresses are then related to the cylindrical polar Reynolds' stresses. An error analysis on the experimental determination of ore of these stresses is indicated but cannot be evaluated without fu rther data. (auth)
Plasma driven permeation of hydrogen through Nb: influence of the surface and bulk defects (2006)

Plasma driven permeation of hydrogen through 25 μm Nb foils was investigated under low‐energy hydrogen ion irradiation in the range of membrane temperature 450–800 K and at different surface conditions. The interaction of hydrogen at molecular, atomic and ionizated states with niobium was under experimental research. The maximum value of low‐temperature steady state permeation efficiency (SPE) was observed at Ar plasma cleaned inlet surface and with insignificant influence of outlet surface conditions. Such result is unusual and contradicts the developed classical representations and other published data for high‐temperature range plasma‐driven permeation. We explain this phenomenon by influence of defect structure of the polycrystalline membrane. The defects lead to the enhanced diffusion of hydrogen atoms along the crystallite sides. Such diffusion can essentially increase SPE of hydrogen through metal at low temperatures. The validity of this explanation was proved by the comparison of molecular hydrogen sorption & desorption measurements in poly‐ and mono‐crystal Nb samples. The weighing method was used in that case. The phase transition β′→α in the Nb‐H system is important for an explanation of SPE temperature dependencies in low‐temperature range. The defects initiate phase transitions. The short‐time enhanced hydrogen permeation was observed after irradiation of a membrane surface by Ar ions. The surface dissociation of the molecular ions, excited molecules and partially ordinary unexcited molecules of hydrogen can explain these observations.
Preparing engineering students for the international virtual workplace (2004)

The "workplace" for engineering is increasingly at the interface of three environments: the virtual environment, in which designs can be created and explored, with activities that range from interaction via the Internet to 3D visualization and immersion in alternative designs of engineered systems; the product realization environment, in which physical embodiments of designs can be produced and evaluated; and the human environment, in which people work together in face-to-face and virtual teams, the latter often internationally dispersed, to design and implement products and processes. Functioning at the interface of these environments is a challenge that must be met by engineering graduates. We discuss how Stevens is addressing this and also considers issues concerning virtual student teams.
Genetische Rekombination bei <i>Nocardia mediterraneî</i> (1974)

Research Articles| October 03 2008 Genetische Rekombination bei Nocardia mediterraneî Subject Area: Further Areas , Oncology , Pathology and Cell Biology T. Schupp; T. Schupp Search for other works by this author on: This Site PubMed Google Scholar R. Huetter R. Huetter Search for other works by this author on: This Site PubMed Google Scholar Pathologia et Microbiologia (1974) 40 (3-4): 149–150. https://doi.org/10.1159/000162518 Article history Published Online: October 03 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation T. Schupp, R. Huetter; Genetische Rekombination bei Nocardia mediterraneî. Pathologia et Microbiologia 31 December 1974; 40 (3-4): 149–150. https://doi.org/10.1159/000162518 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPathobiology Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1974Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Accelerator mass spectrometry (2015)

AccessScience is an authoritative and dynamic online resource that contains incisively written, high-quality educational material covering all major scientific disciplines. An acclaimed gateway to scientific knowledge, AccessScience is continually expanding the ways it can demonstrate and explain core, trustworthy scientific information that inspires and guides users to deeper knowledge.
Staying Up to Date with Changes in IT (2009)

Information and communications technology (ICT) has been changing rapidly over a long period and this rate of change is likely to continue or increase (Benamati & Lederer, 2001a; Lee & Xia, 2005). This rapid rate of change has produced many opportunities for organizations, but has also brought with it many challenges (Benamati & Lederer, 2001b). Among these challenges is the struggle for organizations to obtain personnel with the appropriate information technology (IT) knowledge and skills in order to meet their ICT needs (Byrd & Turner, 2001; Doke, 1999; Standbridge & Autrey, 2001). This is mirrored by the continual requirement for IT professionals to keep up to date with the skills required by organizations (Benamati et al., 2001a; Klobas & McGill, 1993; Moore, 2000). Previous research has investigated the importance employers place on various skills and perceived deficiencies in these skills (e.g., Doke, 1999; Leitheiser, 1992; Nelson, 1991; Prabhakar, Litecky, & Arnett, 2005). While the call for improved communication and social skills has been consistent, the technical skills in demand have varied dramatically over time (Prabhakar et al., 2005; Van Slyke, Kittner, & Cheney, 1998). Less has been written about students’ perceptions of the importance of various ICT skills, though this was addressed in a study that compared Australian and American students’ perceptions of ICT job skills (von Hellens, Van Slyke, & Kittner, 2000). This article provides an overview of a project that investigated the channels of information that ICT students use to keep up to date with employers’ needs.
C-Reactive Protein and Mortality in Hemodialysis Patients: The Dialysis Outcomes and Practice Patterns Study (DOPPS) (2010)

CRP is informative regarding mortality risk beyond that provided by other inflammatory and nutritional markers, with significantly higher risk seen at CRP >3 mg/l. Greater use of CRP may lead to improved patient care as suggested by the association of greater CRP measurement with lower cardiovascular mortality.
Resonating valence bonds and mean-field<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>d</mml:mi></mml:math>-wave superconductivity in graphite (2007)

We investigate the possibility of inducing superconductivity in a graphite layer by electronic correlation effects. We use a phenomenological microscopic Hamiltonian which includes nearest-neighbor hopping and an interaction term which explicitly favors nearest-neighbor spin singlets through the well-known resonance valence bond (RVB) character of planar organic molecules. Treating this Hamiltonian in mean-field theory, allowing for bond-dependent variation of the RVB order parameter, we show that both $s$- and $d$-wave superconducting states are possible. The $d$-wave solution belongs to a two-dimensional representation and breaks time-reversal symmetry. At zero doping there exists a quantum critical point at the dimensionless coupling $J∕t=1.91$ and the $s$- and $d$-wave solutions are degenerate for low temperatures. At finite doping the $d$-wave solution has a significantly higher ${T}_{c}$ than the $s$-wave solution. By using density functional theory we show that the doping induced from sulfur absorption on a graphite layer is enough to cause an electronically driven $d$-wave superconductivity at graphite-sulfur interfaces. We also discuss applying our results to the case of the intercalated graphites, as well as the validity of a mean-field approach.
EDB: a multi-master database for liquid multi-device software (2015)

Device shipment trends indicate that the number of web-enabled devices will grow very rapidly. The rapid growth of different types of devices in our daily lives will fundamentally change the expectations on device synchronization. In this paper, we introduce EDB -- a database architecture that has been built specifically to support automatic multi-master synchronization between multiple mobile devices with potentially intermittent network connectivity. EDB supports the broader vision of multiple device ownership and liquid software in which applications and services are expected to seamlessly roam from one device or computer to another.
Regularization in Deformable Registration of Biomedical Images Based on Divergence and Curl Operators (2013)

The implemented divergence/curl regularization was successfully tested, leading to promising results in comparison with competitive regularization methods. Future work is required to establish parameter tuning and reduce the computational cost.
Effect of Chemisorbed Oxygen on Photovoltaic and Photoconductive Processes in Rutile (1964)

Adsorbed oxygen increases both the response and the response time for the photovoltaic effect in rutile. The model for the effect of chemisorbed oxygen on the photoconductivity has been modified to take into consideration the effect of oxygen pressure. The conductance of rutile, measured as a function of oxygen pressure, agrees with the modified model. The increase in photovoltaic response and response time with exposure to oxygen has been explained in terms of the barrier layer formed by chemisorbed oxygen.
Mixed species live biotherapeutic product improves immunological tolerance in food allergy (2021)

Abstract The human gut microbiota is central to early-life immune system education, including the establishment of immune tolerance, and thus represents an important target for the development of preventative interventions against food allergy (FA). The composition of the gut microbiota, and specific bacterial members within the microbiota, have been shown to impact allergic disease development in animal models by limiting basophil hematopoiesis, influencing macrophage polarization, and enhancing regulatory T cell activity. With a growing body of evidence showing the gut microbiota is an important environmental factor contributing to FA development comes an opportunity to translate this knowledge into novel approaches for treating and preventing FA. Using a proprietary human gut microbiota consortium, we have developed a mixed species live biotherapeutic product (LBP) to alleviate FA development and severity. We show that this LBP can directly interact with human immune cell populations modulating immune signaling pathways including TGF-beta, FFARs, chemotaxis, and NFkB inhibition. We also demonstrate that supplementation with this LBP can reduce OVA induced oral anaphylactic severity in mice with humanized gut microbiota. This protective effect may be attributed to increased fecal antigen-specific IgA levels and enhanced intestinal TGFb levels. These data describe immunological mechanism of a mixed species LBP that is protective in mouse FA model.
Discovery of a Novel 5-HT<sub>3</sub> Antagonist/5-HT<sub>1A</sub> Agonist 3-Amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3<i>H</i>)-one (TZB-30878) as an Orally Bioavailable Agent for Irritable Bowel Syndrome (2010)

We have prepared a series of quinazolinone derivatives linked with piperazinylquinoline for the treatment of irritable bowel syndrome (IBS). Using pharmacophore analysis, we designed and synthesized compounds which bind to both serotonin receptor subtype 1A (5-HT(1A)) and subtype 3 (5-HT(3)). Quinazolinone derivatives with a sulfur atom in the linker showed high affinity in in vitro assays, but low in vivo activity. Focusing on the linker to improve the pharmacokinetic profile, the sulfur atom in the linker was replaced with a methylene group. Further optimization led to the discovery of compound 17m (TZB-30878) ( J. Pharmacol. Exp. Ther. 2007 , 322 , 1315 - 1323 , Patent WO2005082887 (A1), 2005 ), a novel 5-HT(1A) agonist/5-HT(3) antagonist in the 3-aminoquinazolinone series. In in vivo functional assays, 17m dose dependently inhibited the Bezold-Jarisch reflex and induced 5-HT(1A)-mediated behaviors, and in an IBS animal model, 17m significantly inhibited stress-induced defecation. Pretreatment by WAY-100635 (5-HT(1A) antagonist) significantly attenuated but did not abolish the inhibitory effects of 17m. These results suggested that 17m exerted inhibitory effects via both 5-HT(1A) agonistic and 5-HT(3) antagonistic activities and that 17m would be useful as a therapeutic agent for IBS.