gebhart/patrepeval huggingface dataset:
Supraventricular tachycardia in dogs: 65 cases (1990–2007) (2008)

Abstract Objective – To characterize the signalment, clinical findings, and prognosis of dogs with supraventricular tachycardia (SVT). Design – Retrospective study. Setting – North Carolina State University Veterinary Teaching Hospital. Animals, Intervention, and Measurements – Case selection included all patients at the veterinary teaching hospital with SVT during years 1990–2007. Medical records from dogs with at least 1 recorded episode of SVT were extracted. The signalment, history, electrocardiographic, radiographic, and echocardiographic findings, therapy, and response to therapy were reviewed and summarized. Follow‐up was conducted to determine the date and cause of death. Kaplan‐Meier survival curves were constructed and analyzed. The relationships between patient characteristics and responses to therapy and prognosis were evaluated. Main Results – Sixty‐five records documented a diagnosis of SVT. Sixty‐two percent were males. Labrador Retrievers and Boxers were overrepresented compared with the general hospital population. Median age at presentation was 9 years (range 0.5–15.5 y). The median heart rate during SVT was 270/minute (range 187–375/min). The most common presenting complaint was syncope (30%), 23% were asymptomatic at the time of diagnosis. Most dogs had structural heart disease (65%). Median survival was 472 days (<1–2007 d). Identification of sustained SVT (>30 s) did not affect survival ( P =0.50), nor did the presence of congestive heart failure ( P =0.70). Conclusions – The majority of dogs with SVT had structural heart disease or a severe concurrent illness at the time of SVT diagnosis. SVT, though often a persistent and occasionally sustained arrhythmia, does not appear to be a primary factor in mortality.
A CMOS switched-capacitor interface circuit for an integrated accelerometer (2002)

Presents a CMOS interface electronics for monolithic micromachined capacitive accelerometer systems. The interface electronics is a fully differential switched-capacitor charge integrator with its internal clock generator and sensor feedback circuit for closed-loop operation. The circuit is designed for open-loop and closed-loop operations, and provides both digital and differential analog outputs. One of the main advantages of this chip is that it can be monolithically integrated with the sensor, resulting in a considerably increased sensor module performance by decreasing the overall system area, minimizing the interface parasitics, and simplifying the packaging. The interface electronics operates at 200kHz sampling clock and provides an adjustable sensitivity between 0.3 and 1.2V/pF with better than 100aF expected resolution resulting in a 93dB dynamic range for 1Hz bandwidth. The total chip dissipates less than 7.2mW power from a single 5V supply, and occupies an area of 3.4/spl times/3.6 mm/sup 2/ in 3/spl mu/m one-metal two-poly p-well. CMOS process of University of Michigan.
Dipole induced anomalous S-shape I-V curves in polymer solar cells (2009)

A kink is sometimes seen in the I-V curves for organic solar cells. In literature charge blocking has been speculated to be responsible for such kind of anomalous features. In this manuscript, we use poly(3-hexylthiophene):[6, 6]-phenyl-C61-butyric acid methyl ester as our model polymer system and investigate different device structures using ultraviolet photoelectron spectroscopy as our primary tool to investigate the reason for this S-shaped kink. We attribute this anomalous feature to the presence of strong interface dipoles. We further propose a model based on the standard set of Poisson equation, continuity equation, and current density equations including both drift and diffusion components.
L’atteinte d’autres organes (2002)

info:eu-repo/semantics/published
RAPID COMMUNICATION Comparison of Molecular Changes in Cervical Intraepithelial Neoplasia in HIV-Positive and HIV-Indeterminate Subjects (1999)

Objective. HIV infection is associated with an increased inci- dence of cervical malignancy and its precursor lesions (CIN, cer- vical intraepithelial neoplasia) compared with the general popu- lation. We studied the molecular abnormalities in the development of HIV-associated CIN and compared them with those present in CINs arising in HIV-indeterminate subjects (sporadic CIN). Methods. We investigated the presence of human papilloma virus (HPV) sequences, loss of heterozygosity (LOH), and micro- satellite alterations (MAs) at five 3p chromosomal regions using 17 polymorphic markers in precisely microdissected archival tissues from 16 HIV-positive CINs and compared them with those present in 39 sporadic CINs. Results. HPV sequences were detected in 36 of 55 (66%) CIN lesions, and high-risk oncogenic strains (HPV 16 and 18) ac- counted for 15 of them. No differences in the HPV frequencies were found between HIV-associated and sporadic CINs. Allelic losses at one or more chromosome 3p regions were frequently detected in CIN lesions (49%). The overall frequency of 3p LOH and the frequencies at all individual regions were similar in HIV- associated and sporadic CINs. The frequency of MA present in the HIV-associated CIN cases (0.093) was sixfold greater than in sporadic CINs (0.014; P 5 0.0001). At least 1 MA was present in 11 (69%) of 16 HIV-associated vs 5 of 39 (13%) sporadic CIN (P 5 0.0006). Molecular changes were independent of the presence of HPV sequences. Conclusion. Chromosome 3p deletions are frequently detected in the precursor lesions of cervical carcinoma (CIN) and there are no differences in the 3p LOH frequencies between HIV-associated and sporadic CIN lesions. Microsatellite alterations, which reflect widespread genomic instability, occur at greatly increased fre- quency in HIV-associated CIN. Although the mechanism under- lying the development of increased MAs is unknown, it may play a crucial role in the development of many HIV-associated neoplasias. © 1999 Academic Press
Controlled Frequency Entanglement of Photons in Type-II Spontaneous Parametric Down-Conversion (2009)

We report broadband entangled photon sources that have control capability of the frequency entanglement. Directly observing the frequency correlation between the constituent photons, we demonstrate the biphoton sources consisting of frequency-correlated or frequency-anticorrelated photons.
Estrogen-like Activity of Digitalis (1965)

Vaginal smears of 52 postmenopausal women who had been taking digitoxin for periods of three months to 15 years were studied for possible estrogen-like effect on epithelial maturation. The pattern of cells from 20 women who had been taking digitoxin for over two years showed marked maturation of vaginal squamous epithelium, closely simulating the effect of estrogens. Of the 32 women who had been taking digitoxin less than two years, only three showed marked maturation of the squamous epithelium. Four of the 50 control patients exhibited moderate estrogenic effect. None showed marked maturation of vaginal epithelium.
Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies (2015)

Although the p value did not reach a conventional genome-wide level of significance in our two-stage GWAS, we obtained significant results in the subsequent analyses that suggest that the rs2653349 SNP (Val308Ile) could be a genetic factor that is related to nicotine dependence and possibly pain, schizotypal personality traits, and goiter in the Japanese population.
Stable Phenoxy-radicals (1968)

The present review is devoted to an examination and analysis of published data on reactions leading to the formation of phenoxy-radicals, and the structures and properties of these radicals. In the description of the methods of preparing phenoxy-radicals, we examine the interaction of sterically hindered phenols with organic peroxides and inorganic oxidising agents, the mechanism of the thermal decomposition of cyclohexadienones, the autoxidation of sterically hindered phenols, and also the action of γ-radiation and ultraviolet radiation on phenols. In the section devoted to the properties of phenoxy-radicals, we discuss the influence of steric hindrance of the reactive centre, and also the degree of delocalisation of the unpaired electron, on the stability of the phenoxy-radicals. The available published data on the chemical transformations of substituted phenoxy-radicals are reviewed. Their recombination, disproportionation, isomerisation, and reaction with oxygen and halogens are examined. The influence of the steric and polar properties of substituents on the kinetics and mechanism of the transfer of hydrogen from organic compounds to stable phenoxy-radicals is analysed. The bibliography contains 180 references.
Slotted-wall blockage corrections for disks and parachutes (1991)

Bluff shapes, including parachutes, often require large blockage corrections when tested in solid-wall wind tunnels. The magnitude of the correction is much smaller in test sections with slotted walls, but the blockage becomes a complicated function of model size, wall porosity, and upstream and downstream boundary conditions. Disk and parachute models were tested in a low-speed wind tunnel where the slotted-wall open area ratio and model axial position were systematically carried. In steady flow, the benefit of the wall slots was achieved asymptotically as the models were moved downstream from the leading edge of the slots, and this flow development length increased with decreasing wall porosity and increasing model size. The experiments with the parachutes provided the first quantitative information on wall interference and tunnel circuit response during the nonsteady inflation process. There was no observable block age effect during the inflations with any of the slotted-wall configurations studied.
Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes. (2000)

Werner syndrome (WRN) is an uncommon autosomal recessive disease in which progeroid features are associated with genetic instability and an elevated risk of neoplasia. We have used the glycophorin A (GPA) somatic cell mutation assay to analyze genetic instability in vivo in WRN patients and heterozygotes. GPA variant frequencies were determined for 11 WRN patients and for 10 heterozygous family members who collectively carry 10 different WRN mutations. Genetic instability as measured by GPA O/N allele loss variant frequency was significantly increased, and this increase was strongly age-dependent in WRN patients. GPA O/N allele loss variants were also significantly elevated in heterozygous family members, thus providing the first evidence for in vivo genetic instability in heterozygous carriers in an autosomal recessive genetic instability syndrome. Our results and comparable data on other human genetic instability syndromes allow an estimate of the level of genetic instability that increases the risk of human bone marrow dysfunction or neoplasia.
Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities (2019)

Abstract We conducted a genome-wide association meta-analysis of two ischemic white matter disease subtypes in the brain, periventricular and deep white matter hyperintensities (PVWMH and DWMH). In 26,654 participants, we found 10 independent genome-wide significant loci only associated with PVWMH, four of which have not been described previously for total WMH burden (16q24.2, 17q21.31, 10q23.1, 7q36.1). Additionally, in both PVWMH and DWMH we observed the previous association of the 17q25.1 locus with total WMH. We found that both phenotypes have shared but also distinct genetic architectures, consistent with both different underlying and related pathophysiology. PVWMH had more extensive genetic overlap with small vessel ischemic stroke, and unique associations with several loci implicated in ischemic stroke. DWMH were characterized by associations with loci previously implicated in vascular as well as astrocytic and neuronal function. Our study confirms the utility of these phenotypes and identifies new candidate genes associated only with PVWMH.
Electronic properties of new organic conductors (1984)

Abstract We have undertaken a study of the electronic properties of a new organic conductor, (BEDT-TTF)2 BrO4, using magnetic resonance techniques and also the organic superconductor (BEDT-TTF)2I3. Proton magnetic resonance experiments on (BEDT-TTF)2 BrO4 have resolved individual proton lines without the aid of line narrowing techniques. The electron spin resonance line is very narrow and shows a frequency independent low temperature broadening in the low temperature regime. The ESR broadening is strongly pressure dependent, being suppressed to lower temperature with the application of pressure. We have used radio frequency techniques to monitor the pressure dependence of the superconducting transition temperature, Tc, in (BEDT-TTF)2I3 and find that Tc is suppressed to below 1K with the application of less than 0.5 kbar of pressure. In addition, we find a magnetic transition at 7K above a pressure of .5 kbar.
A 12.5-Gb/s Pulse Modulator with 6.5-ps FWHM Using 0.1-&#956;m InP HEMTs for Ultra-Wideband Impulse Radio Communications (2008)

We developed an ON/OFF pulse modulator IC using 0.1-mum-gate-length InP HEMTs for ultra-wideband impulse radio (UWB-IR) communications systems. The IC generated extremely short pulses whose full width at half maximum (FWHM) were 6.5 ps. Furthermore, our new circuit architecture that retimes output pulses at both rising and falling edges made the IC robust against timing fluctuations or jitter. The output pulses had very small jitters of 256 fs rms and 1.3 ps p-p and thus had little degradation from intersymbol interference (ISI) when a 231-1 length pseudo random bit stream (PRBS) at a bit rate of 12.5 Gb/s was input. The pulse modulator can be used to construct an ON/OFF keying transmitter based on UWB-IR architecture that sends more than 10 Gb/s of data in the W-band (75-110 GHz) and above.
Bio-inspired Tensegrity Soft Modular Robots (2017)

In this paper, we introduce a design principle to develop novel soft modular robots based on tensegrity structures and inspired by the cytoskeleton of living cells. We describe a novel strategy to realize tensegrity structures using planar manufacturing techniques, such as 3D printing. We use this strategy to develop icosahedron tensegrity structures with programmable variable stiffness that can deform in a three-dimensional space. We also describe a tendon-driven contraction mechanism to actively control the deformation of the tensegrity mod-ules. Finally, we validate the approach in a modular locomotory worm as a proof of concept.
In vivo comparison of 16. cap alpha. -(/sup 77/Br)bromoestradiol-17. beta. and 16. cap alpha. -(/sup 125/I)Iodoestradiol-17. beta (1982)

An in vivo comparison of two estrogen-receptor-binding radiopharmaceuticals of high specific activity, 16..cap alpha..-(/sup 77/Br)bromoestradiol-17..beta.. and 16..cap alpha..-(/sup 125/I)iodoestradiol-17..beta.., has been carried out in immature female rats. The iodoestradiol has slightly higher uterine uptake at 1 hr after injection, whereas the brominated analog has significantly enhanced uptake at later times. The similar behavior of the two compounds in vivo suggests that estradiol labeled with I-123, Br-77, or Br-75 could be used interchangeably for the imaging of breast tumors containing estrogen receptors. In addition, coinjection of 16..cap alpha..-(/sup 125/I)iodoestradiol as an internal standard has been shown to be useful for comparison of different radiohalogenated estrogens. 17 references, 4 tables, 1 figure.
Comparative analyses of genomic locations and race specificities of loci for quantitative resistance to <i>Pyricularia grisea</i> in rice and barley (2003)

Comparative genomic analyses have revealed extensive colinearity in gene orders in distantly related taxa in mammals and grasses, which opened new horizons for evolutionary study. The objective of our study was to assess syntenic relationships of quantitative trait loci (QTL) for disease resistance in cereals by using a model system in which rice and barley were used as the hosts and the blast fungus Pyricularia grisea Sacc. as the pathogen. In total, 12 QTL against three isolates were identified in rice; two had effects on all three isolates, and the other 10 had effects on only one or two of the three isolates. Twelve QTL for blast resistance were identified in barley; one had effect on all three isolates, and the other 11 had effects on only one or two of the three isolates. The observed isolate specificity led to a hypothesis about the durability of quantitative resistance commonly observed in many plant host-pathogen systems. Four pairs of the QTL showed corresponding map positions between rice and barley, two of the four QTL pairs had complete conserved isolate specificity, and another two QTL pairs had partial conserved isolate specificity. Such corresponding locations and conserved specificity suggested a common origin and conserved functionality of the genes underlying the QTL for quantitative resistance and may have utility in gene discovery, understanding the function of the genomes, and identifying the evolutionary forces that structured the organization of the grass genomes.
Pain report and the relationship of pain to physical factors in the first 6 months following spinal cord injury (1999)

A prospective, longitudinal study of 100 people with traumatic spinal cord injury (SCI) was performed to determine the time of onset. prevalence and severity of different types of pain (musculoskeletal, visceral, neuropathic at level, neuropathic below level) at 2, 4, 8, 13 and 26 weeks following SCI. In addition, we sought to determine the relationship between physical factors such as level of lesion, completeness and clinical SCI syndrome and the presence of pain. At 6 months following SCI, 40% of people had musculoskeletal pain, none had visceral pain, 36% had neuropathic at level pain and 19% had neuropathic below level pain. When all types of pain were included, at 6 months following injury, 64% of people in the study had pain, and 21% of people had pain that was rated as severe. Those with neuropathic below level pain were most likely to report their pain as severe or excruciating. There was no relationship between the presence of pain overall and level or completeness of lesion, or type of injury. Significant differences were found, however, when specific types of pain were examined. Musculoskeletal pain was more common in people with thoracic level injuries. Neuropathic pain associated with allodynia was more common in people who had incomplete spinal cord lesions, cervical rather than thoracic spinal cord lesions, and central cord syndrome. Therefore, this study suggests that most people continue to experience pain 6 months following spinal cord injury and 21% of people continue to experience severe pain. While the presence or absence of pain overall does not appear to be related to physical factors following SCI, there does appear to be a relationship between physical factors and pain when the pain is classified into specific types.
Serological and immunohistochemical detection of a gastrointestinal cancer-associated asialoglycoprotein antigen of human with a murine monoclonal antibody. (1987)

A murine monoclonal antibody (mAb), NCC-AS 13 (IgM, kappa), was produced after immunization with ascites from a gastric cancer patient. In a sandwich enzyme immunoassay, NCC-AS 13 reacted with the sera from 32% of 58 gastric cancer patients, 44% of 9 hepatocellular cancer patients and 33% of 6 colorectal cancer patients. Immunohistological analysis showed NCC-AS 13 to react with approximately 90% of 51 gastric carcinomas, 12 out of 12 colon carcinomas and 3 out of 4 lung carcinomas. The NCC-AS 13 defined antigen was determined to be a carbohydrate without terminal sialic acid on macromolecular glycoproteins. This mAb NCC-AS 13, detecting a novel antigen associated with gastrointestinal cancers, may have potential uses for tumor immunoscintigraphy and for the therapy of gastric cancer patients.
Effect of essential oils on the concentration of serum lipids and apolipoproteins in rats. (1985)

Essential oils are widely used as food additives, although few studies of their effects on physiological functions have been carried out. Benko et al. in 1961 showed that essential oils prevented atheroma formation in cholesterol-fed rabbits.^More recently, Rowachol, a proprietary choleretic preparation composedof menthol (32%), pinene (17%), menthone (6%), borneol (5%), camphene (5 %) and cineol (2 %) in olive oil, was shown to elevate cholesterol in serum high density lipoproteins (HDL) in humans.2) Oxygen-containing monoterpenes in Rowachol (menthol, borneol and cineol) reduced the ac-
A decoupled flexible‐relative co‐ordinate recursive approach for flexible multibody dynamics (1991)

Abstract An extended kinematic graph concept and a variational‐vector calculus approach are employed to develop a new recursive formulation for the dynamic analysis of flexible multibody systems. The extended graph concept introduced defines frames and transformations between frames as nodes and edges, respectively, rather than the more traditional body and joint convention. Kinematic relationships between adjacent flexible bodies are derived, using joint relative co‐ordinates and a state vector notation that represents both translational and rotational components of velocity. Deformation kinematics are formulated in terms of modal co‐ordinates, under small deformation assumptions. Joint relative co‐ordinates are decoupled from deformation modal co‐ordinates in both kinematic relations and in the recursive dynamics algorithm, leading to a significant reduction in the dimension of matrices that must be inverted. Dynamic analysis of a flexible closed‐loop spatial robot is performed to illustrate the efficiency of the algorithm.
ChemInform Abstract: L‐696,986: A Functionally Selective and Potent Muscarinic M1 Receptor Partial Agonist. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Percutaneous Tumor Ablation: Reduced Tumor Growth with Combined Radio-frequency Ablation and Liposomal Doxorubicin in a Rat Breast Tumor Model (2003)

Combined RF ablation and liposomal doxorubicin retards tumor growth and may increase animal survival compared with that with either therapy alone or no therapy.
Transmission Loss Allocation Based on a New Quadratic Loss Expression (2006)

This paper presents a derivation of a new quadratic expression for the transmission loss in a power system. The main advantage of this expression is the improvement in accuracy over the other existing approximations. Furthermore, this improved quadratic form allows the transmission loss to be expressed in terms of nodal power injections. This paper builds on the derived loss expression and proposes a bus-loss matrix. This matrix is useful in quantifying the interactions among different bus power injections and establishing a loss allocation scheme for individual buses. Numerical examples are used to illustrate the accuracy of the derived quadratic form and its use in loss allocation