gebhart/patrepeval huggingface dataset:
An Investigation Concerning the Potential for use of Polylactic/Polyglycolic Acid Confluent Sheets in the Treatment of Osseous Defects, (1992)

Abstract : Polylactic/polyglycolic acid combinations (alpha polyamides) are biodegradable materials commonly used in suture materials and surgical meshes for the temporary support of abdominal organs. The materials are well known in the clinical literature and have been in common usage without risk for over two decades. The polyamides are rich in polyester linkages that are degraded in aqueous environments by hydrolysis. Various investigators have shown that the pure form of polyglycolic acid (PGA) degrades over a period of 5 months whereas pure polylactic acid (PLA) takes about 6.5 months. Copolymers of PLA/PGA have been synthesized that degrade within a few weeks to several months depending upon the ratios employed and the specific sequencing of the chemical units. Further, the alpha polyamides show no adverse host tissue reactions when implanted in numerous animal models.
Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion (1993)

Tpl-2 is a gene encoding a protein kinase which is primarily expressed in normal spleen, thymus, and lung tissue and is activated by provirus insertion in Moloney murine leukemia virus-induced T-cell lymphomas during the late stages of oncogenesis. Tpl-2 is composed of eight exons and spans a 35-kb genomic DNA region. The provirus integrates reproducibly in the last intron and in the same transcriptional orientation as the Tpl-2 gene. This genetic change leads to the expression of enhanced steady-state levels of a truncated Tpl-2 RNA transcript which is predicted to encode a protein with an altered C-terminal domain. Tpl-2 is transcribed from two alternating promoters, P1 and P2. The RNA transcripts originating in the two promoters harbor different 5' untranslated regions derived from the alternate noncoding exons IA and IB. Utilization of the P2 promoter, which gives rise to exon IB containing Tpl-2 RNA transcripts, was detected primarily in tumor cells. The Tpl-2 protein was expressed in COS-1 cells as an N-terminal fusion with a 12-amino-acid hemagglutinin tag. Immunoprecipitation of transfected COS-1 cell lysates with antihemagglutinin or anti-Tpl-2 antibodies, followed by incubation with [gamma-32P]ATP, confirmed that Tpl-2 possesses protein kinase activity.
Fluorous “Racemic” Mixture Synthesis: Simultaneous Strategy for Demixing and Enantioseparation of Racemic Fluorous‐Tagged Products (2007)

Abstract Reported herein is the concept of fluorous “racemic” mixture synthesis (FRMS), which is applied to two types of proof‐of‐concept experiments. Mixtures of racemic O ‐benzoylmandelate derivatives and prochiral crotonamide derivatives, respectively, bearing different lengths of fluorous‐cleavable tags are taken through a segmented reaction sequence to provide their enantiomers, as well as their individual derivatives, by virtue of chiral β‐cyclodextrin columns. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Method for Orienting DNA Molecules on Mica Surfaces in One Direction for Atomic Force Microscopy Imaging (2001)

An efficient method was developed to stretch DNA molecules on an atomically flat surface for AFM imaging. This method involves anchoring DNA molecules from their 5' ends to amino silanized mica surfaces. N-Succinimidyl6-[3'-(2-pyridyldithio) propionamido]hexanoate (LC-SPDP), a heterobifunctional cross-linker with a flexible spacer arm was used for this purpose. Immobilization was carried out by introducing a thiol group to the 5' end of DNA by PCR. Thiolated molecules were then reacted with the cross linker to conjugate with its 2-pyridyl disulphide group via sulfhydryl exchange. The resulting complex was deposited on amino silanized mica where NHS-ester moiety of the cross linker reacted with the primary amino group on the surface. Samples were washed by a current of water and dried by an air jet in one direction parallel to the surface. DNA molecules were fully stretched in one direction on imaging them by AFM.
Molecular Thermodynamics of Simple Liquids. Pure Components (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular Thermodynamics of Simple Liquids. Pure ComponentsHenri Renon, C. A. Eckert, and J. M. PrausnitzCite this: Ind. Eng. Chem. Fundamen. 1967, 6, 1, 52–58Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://pubs.acs.org/doi/10.1021/i160021a008https://doi.org/10.1021/i160021a008research-articleACS PublicationsRequest reuse permissionsArticle Views386Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Adults with Down Syndrome: Safety and Long-term Outcome of Cardiac Operation (2010)

At an experienced center, adult patients with Down syndrome can undergo cardiac surgery with a low risk of mortality and acceptable morbidity. Atrial arrhythmias and pulmonary infections are common postoperatively.
Guide to Intermediate Band Solar Cell Research (2012)

The intermediate band solar cell (IBSC) is a solar cell that, in order to increase its efficiency over that of single gap solar cells, takes advantage of the absorption of below-bandgap energy photons by means of an intermediate band (IB) located in the semiconductor bandgap. For this process to improve the solar cell performance, the belowbandgap photon absorption has to be effective and the IB cannot limit the open-circuit voltage of the cell. In this paper we provide a guide to the new researcher interested in the idea in order he can quickly become familiar with the concept and updated with the most relevant experimental results.
Buried heterostructure laser fabricated using three-step gas source molecular beam epitaxy (1991)

Buried heterostructure lasers fabricated using a three-step gas source molecular beam epitaxy (GSMBE) process are presented for the first time. We propose a new structure design compatible with nonselective regrowth for the blocking layers, therefore avoiding the use of a dielectric mask. The structure is terminated by a second overgrowth after a material lift-off. Preliminary results show cw operation with threshold currents of 60 mA for 800-μm-long devices and maximum output power up to 27 mW per facet.
ANALOGUE COMPUTER FOR CALCULATING AND ADJUSTING TRILATERATION NETS (1962)

The trilateration method of determining geodetic coordinates has become increasingly significant since the introduction of optic-electrical and electronic methods for the measurement of distances. The associated problem of computation and adjustment of trilateration nets has already received much attention, and the solution of large systems of equations does not present unsurmountable difficulties now that electronic computers are more readily available. Nevertheless, it is interesting—and not only for theoretical reasons—to investigate the possibilities of solving this problem using a mecahnical analogue computer based on the principle of elastic systems.
Assignment of the <sup>13</sup>C chemical shifts of ethidium bromide and analogs in D<sub>2</sub>O solution (1980)

Abstract The 13 C resonances of ethidum bromide (1), dimidium bromide (2) and 3,8‐diamino‐5‐methylphenanthridinium chloride (3) in D 2 O solution have been assigned. Assignments were made using fully coupled spectra, spectra obtained from a selected 180°‐τ‐90° pulse sequence in conjunction with gated irradiation to obtain NOE intensification, selective proton decoupling, chemical shift arguments and by noting the effect of pD on the 13 C chemical shifts of 1 and 3.
The Fate of [ <sup>125</sup> I] -Labeled Human Leukocyte-Derived Alpha Interferon in the Rat (1985)

In order to follow the catabolic fate of interferon in the body, [125I]-labeled human alpha interferon was infused into rats. Interferon activity and TCA-precipitable radioactivity in the blood reached a steady state after 60 min of infusion, while TCA-soluble radioactivity continued to increase during the entire infusion period. A massive accumulation of both active interferon and degradation products of interferon were found in the kidney at the end of the infusion. Most of the interferon activity was found in the mitochondrial-lysosomal fraction, while most of the interferon degradation products were found in the supernatant fraction. Ligation of the kidney's blood vessels resulted in a large increase of interferon activity in the blood. Only a small increase was found in other organs, with no increase at all in radioactive degradation products. Our results suggest the kidney to be the main site of interferon catabolism. Low molecular weight degradation products are excreted from the kidney into the blood and are at least partially secreted in the urine and also taken up by other organs.
Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment. (2005)

This review examines the differences in the incidence, spectrum, and mechanisms of activation of opportunistic infections, such as Mycobacterium tuberculosis, in patients with rheumatic diseases treated with the soluble TNF p75 receptor etanercept compared to the 2 anti-TNF-alpha monoclonal antibodies, infliximab and adalimumab.
Corrigendum: Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir With or Without Ribavirin in HCV-Infected Patients Taking Concomitant Acid-Reducing Agents (2016)

Shiffman, Mitchell L.; Rustgi, Vinod; Bennett, Michael; Forns, Xavier; Asselah, Tarik; Vila, Ramon Planas; Liu, Li; Pedrosa, Marcos; Moller, Jonathan; Reau, Nancy
Studies of Structure and Switching Dynamics in Ferroelectric Crystal and Liquid Crystal Thin Films (1989)

Abstract : The structure and switching dynamics of ferroelectric solid state and liquid crystal thin films were investigated experimentally using x-ray scattering, optical microscopy and microspectroscopy, and by raman spectroscopy. Applications of crystalline piezoelectric ferroelectric films, formed by sol gel and sputter deposition and ferroelectric liquid crystal devices were studied for application. Keywords: Ferroelectric crystals; Ferroelectric liquid crystals; Ferroelectric thin films.
Laser spectroscopy and lifetime measurements of Dy i states (1991)

The dysprosium spectrum is studied in the range of 273-284 nm by using pulsed-laser excitation in an atomic beam and fluorescence detection. Lifetimes and branching ratios for the decay to the ground term are determined from the analysis of fluorescence signals for 27 high-lying odd-parity levels.
Versuchsauswertung (1975)

Die Berechnung der Kenngrößen aus den Meßwerten wurde auf der elektronischen Rechenanlage des Rechenzentrums der RWTH-Aachen durchgeführt.
ChemInform Abstract: Matrix Infrared Spectroscopy of Intermediates with Low Coordinated Carbon, Silicon and Germanium Atoms (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parametric excitation of ion quasi-mode by the pump near the ion cyclotron frequency (1980)

Parametric excitation of a nonresonant ion quasi-mode in a low density (i.e., ωpi≈Ωi) plasma is observed when the pump frequency is ω0≳2Ωi. From the interferometry measurement, the lower sideband is identified to be the cold lower hybrid wave and the low-frequency mode is shown to be a nonresonant ion quasi-mode. The dependence of the excitation process and the threshold upon density has been measured and was found to agree well with theory. The ion heating associated with this decay process is also observed. Such processes may take place near the plasma surface during ion cyclotron range of frequency heating experiments in tokamaks.
Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration (2019)

The most prominent cancer-associated fibroblasts (CAFs) in tumor stroma is known to form a protective structure to support tumor growth. Anterior gradient-2 (AGR2), a tumor secretory protein is believed to play a pivotal role during tumor microenvironment (TME) development. Here, we report that extracellular AGR2 enhances fibroblasts elongation and migration significantly. The early stimulation of RhoA showed the association of AGR2 by upregulation of G1-S phase-regulatory protein cyclin D1 and FAK phosphorylation through fibroblasts growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR). Our finding indicates that secretory AGR2 alters fibroblasts elongation, migration, and organization suggesting the secretory AGR2 as a potential molecular target that might be responsible to alter fibroblasts infiltration to support tumor growth.
Inactivation of a Single Eucaryotic Gene Irradiated in Vitro in Transcriptionally Active Chromatin Form (1986)

The transcriptional activity of endogenous RNA polymerases has been used to study the inactivation of a single eucaryotic gene irradiated in chromatin form in aqueous solution. The gene codes for the ribosomal RNA precursor in Tetrahymena where it exists in multiple copies as free extrachromosomal molecules. The gene chromatin is isolated with intact RNA polymerases on the coding strand. Irradiation with 10-MeV electrons reduces the in vitro RNA synthesis on the isolated chromatin in a dose-dependent manner which allows the amount of DNA damage to be determined. Irradiation of the gene chromatin in dilute solution under various gas atmospheres demonstrates that OH radicals account for most of the inactivation. Under these conditions, $e_{{\rm aq}}^{-}$ is unimportant, while the results suggest that H may contribute to inactivation of gene transcription.
Distinguishing photographs and graphics on the World Wide Web (1997)

When we search for images in multimedia documents, we often have in mind specific image types that we are interested in; examples are photographs, graphics, maps, cartoons, portraits of people, and so on. This paper describes an automated system that classifies Web images as photographs or graphics. The design of the system is based on statistical observations about the image content of the two types, as well as learning techniques which make use of the vast amount of training data available on the Web. Text associated with the image can be used to further improve the accuracy of the classification. The system is used as a part of Webseer, an image search engine for the Web
Studies on Acetylenic Compounds. XXIV (1962)

It was found that the use of cuprous chloride in the Grignard reaction of α, β-acetylenic acid resulted in the 1, 4-addition reaction.Several reactions were carried out with compounds having methyl, butyl, or phenyl as R and R′ in the above formulae and it was found that interchange of R and R′ resulted in the formation of the same 3, 3-disubstituted acrylic acid, i.e.a stable trans compound. From this fact, this 1, 4-addition reaction was assumed to proceed through the formation of an intermediate (A).
Detection of Cryptosporidium parvum Oocysts on Fresh Produce Using DNA Aptamers (2015)

There are currently no standard methods for the detection of Cryptosporidium spp., or other protozoan parasites, in foods, and existing methods are often inadequate, with low and variable recovery efficiencies. Food testing is difficult due to the low concentrations of parasites, the difficulty in eluting parasites from some foods, the lack of enrichment methods, and the presence of PCR inhibitors. The main objectives of the present study were to obtain DNA aptamers binding to the oocyst wall of C. parvum, and to use the aptamers to detect the presence of this parasite in foods. DNA aptamers were selected against C. parvum oocysts using SELEX (Systematic Evolution of Ligands by EXponential enrichment). Ten rounds of selection led to the discovery of 14 aptamer clones with high affinities for C. parvum oocysts. For detecting parasite-bound aptamers, a simple electrochemical sensor was employed, which used a gold nanoparticle-modified screen-printed carbon electrode. This aptasensor was fabricated by self-assembling a hybrid of a thiolated ssDNA primer and the anti- C. parvum aptamer. Square wave voltammetry was employed to quantitate C. parvum in the range of 150 to 800 oocysts, with a detection limit of approximately 100 oocysts. The high sensitivity and specificity of the developed aptasensor suggests that this novel method is very promising for the detection and identification of C. parvum oocysts on spiked fresh fruits, as compared to conventional methods such as microscopy and PCR.
ChemInform Abstract: UNGEWOEHNLICHE PRODUKT‐VERTEILUNG BEI DER DEHYDROBROMIERUNG VON DIBROMMETHYLCYCLOHEXANEN (1972)

Abstract 1,2‐Dibrom‐1‐methyl‐cyclohexan (I) wird durch Natriummethylat bei 110 ‐ 115°C zu den Kohlenwasserstoffen (II)‐(V) dehydrobromiert, wobei zu 77% Methylen‐cyclohexen (II) entsteht.
Design of systematic GIRA codes for CPM (2014)

In this paper, we derive an asymptotic analysis for the design of serially concatenated turbo schemes that works for both systematic generalized irregular repeat accumulate (GIRA) and low density generator matrix (LDGM) codes concatenated with a continuous phase modulation (CPM). The proposed design is based on a semi-analytic EXIT chart optimization method. By considering a particular scheduling, inserting partial interleavers between GIRA accumulator and CPM and allowing degree-1 variable nodes, we show that one can achieve very good thresholds.
How many smart meters can be deployed in a GSM cell? (2013)

The need to deploy large number of wireless devices, such as electricity or water meters, is becoming a key challenge for any utility. Furthermore, such a deployment should be functional for more than a decade. Many cellular operators consider LTE to be the single long term solution for wide area connectivity serving all types of wireless traffic. On the other hand, GSM is a well-adopted technology and represents a valuable asset to build M2M infrastructure due to the good coverage, device maturity, and low cost. In this paper we assess the potential of GSM/GPRS/EDGE to operate as a dedicated network for M2M communications. In order to enable M2M-dedicated operation in the near future, we reengineer the GSM/GPRS/EDGE protocol in a way that requires only minor software updates of the protocol stack. We propose different schemes to boost the number of M2M devices in the system without affecting the network stability. We show that a single GSM cell can support simultaneous low-data rate connections (e. g. to smart meters) in the order of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> devices.
Effects of hydrostatic pressure on membrane processes. Sodium channels, calcium channels, and exocytosis. (1987)

A patch-clamp study under high hydrostatic pressure was performed by transferring cells or membrane patches into a pressure vessel (Heinemann, S. H., W. Stühmer, and F. Conti, 1987, Proceedings of the National Academy of Sciences, 84:3229-3233). Whole-cell Na currents as well as Ca currents were measured at pressures up to 40 MPa (approximately 400 atm; 1 MPa = 9.87 atm) in bovine adrenal chromaffin cells. Ca currents were found to be independent of pressure within experimental resolution. The mean amplitude and the gating kinetics of Na currents were affected by less than 20% at 10 MPa. This lack of a pronounced effect is surprising since the high-pressure nervous syndrome (HPNS), a disorder at high pressures known to result from impaired nervous transmission, manifests itself at pressures as low as 5 MPa. The results show that ion channels involved in transmission cannot be implicated in HPNS. However, when exocytosis was studied at high pressure by monitoring the cell capacitance (Neher, E., and A. Marty, 1982, Proceedings of the National Academy of Sciences, 79:6712-6716), more drastic effects were seen. The degranulation evoked by dialyzing the cell with 1 microM free Ca2+ could be slowed by a factor of 2 by application of 10 MPa. The same effect was observed for the degranulation of rat peritoneal mast cells stimulated with 40 microM of the GTP analogue GTP-gamma-S. According to these results, the process of exocytosis is the most likely site at which hydrostatic pressure can act to produce nervous disorders. Furthermore, we demonstrate that pressure can be a useful tool in the investigation of other cellular responses, since we were able to separate different steps occurring during exocytosis owing to their different activation volumes.
Electrolytes and Osmolality in Alcoholics During Experimentally Induced Intoxication (1968)

Serum and urine osmolality and electrolytes were measured in 6 alcoholic subjects prior to, during, and following a period of experimentally induced ethanol intoxication. A significant increase in serum osmolality was correlated with increased levels of serum sodium. Diuresis only occurred during the initial phase of alcohol administration and did not persist during prolonged drinking. Hematocrit levels decreased although dietary and vitamin intake was adequate. A significant decrease in urine electrolyte excretion occurred during the alcohol ingestion phase even though urine volume output did not differ from prealcohol values. It is postulated that chronic ethanol intake is associated with electrolyte derangements which cannot be explained by known diuretic or hormonal changes induced by ethanol ingestion.