gebhart/patrepeval huggingface dataset:
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression (2018)

The mRNA modification N<sup>6</sup>-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes with phenotypic outputs during cancer progression. Here we report that m6A levels are significantly decreased in genetically-defined immortalized and oncogenically-transformed human mammary epithelial cells (HMECs), as compared with their primary cell predecessor. Furthermore, the m6A methyltransferase (METTL3) is decreased and the demethylase (ALKBH5) is increased in the immortalized and transformed cell lines, providing a possible mechanism for this basal change in m6A levels. Although the immortalized and transformed cells showed lower m6A levels than their primary parental cell line, overexpression of METTL3 and METTL14, or ALKBH5 knockdown to increase m6A levels in transformed cells increased proliferation and migration. Remarkably, these treatments had little effect on the immortalized cells. Together, these results suggest that m6A modification may be downregulated in immortalized cells as a brake against malignant progression. Finally, we found that m6A levels in the immortalized and transformed cells increased in response to hypoxia without corresponding changes in METTL3, METTL14 or ALKBH5 expression, suggesting a novel pathway for regulation of m6A levels under stress.
3-D seismic: Is the promise fulfilled? (1992)

Since the first 3-D survey 17 years ago, companies of the Shell Group have operated over 250 such surveys outside North America and, as non-operating partners, have been involved in many others. The method’s power to produce high-resolution images of the subsurface has been thoroughly proven, and it has become increasingly apparent that subsurface models resulting from mapping with 2-D seismic lack the detail provided by the 3-D method. Also, amplitude effects (caused by variations in porefill and/or lithology) and more easily seen on 3-D seismic than on 2-D profiles. Thus, in addition to its initial use for structural mapping, 3-D seismic is used increasingly to evaluate trends in reservoir quality.
Crash Sensors for Inflatable Occupant Restraint Systems (1972)

<div class="htmlview paragraph">Several IORS crash sensors are compared with respect to operating principle, performance, and potential vehicular use. Desirable characteristics of the sensor mount are described. Forward mounted crash sensors are discussed as a means of providing early crash discrimination.</div> <div class="htmlview paragraph">Rough road and barrier test results with crash sensors are reviewed.</div>
Sterically‐crowded pyrroles (1968)

Abstract The syntheses in good yields of a considerable number of moderately to severely sterically‐crowded 1,2,5‐trisubstituted pyrroles by means of modifications of the Knorr‐Paal condensation are described. Notwithstanding reports to the contrary, the classical procedure; succeeded in moderately sterically‐crowded cases, e.g. , R 2 = R 5 = Me, R 1 = i‐Pr, Me 2 CHMeCH‐, Me 2 N‐, Ph 2 N‐, 9‐carbazolo, subst. 4‐morpholino, 1‐piperazino, 1‐piperidino, etc. A product‐water azeotroping procedure succeeded in more severely sterically‐crowded cases e.g. , R 2 = R 5 = Et, R 1 = i‐Pr; R 2 = R 5 = Me, R 1 = Me 3 CCH 2 ‐, R 2 = R 5 = i‐Pr, R 1 = PhCH 2 ‐. Highly sterically‐crowded pyrroles, e.g. , R 2 = R 5 = Me, R 1 = t ‐Bu, adamantyl, PhCH 2 CMe 2 ; R 2 = R 5 = Et, R 1 = t ‐Bu; R 1 = R 2 = R 5 = i‐Pr; R 2 = R 5 = t ‐Ru, R 1 = Me, Et, PhCH 2 ‐, were obtained using titanium tetrachloride as a Lewis acid catalyst and as a water scavenger. Infrared spectra of the reacting mixtures provided evidence pertinent to the mechanism of the reaction, which is discussed.
The design of multiplierless FIR filters for compensating D/A converter frequency response distortion (1988)

Designs are presented for multiplierless linear-phase FIR digital filters for compensating the sinc(x) frequency-response distortion resulting from D/A conversion. The filter coefficients are represented by a simple canonic single-digit code, and thus the filter can be implemented using only a few adders and delay registers. A 7-tap design is given which compensates the D/A distortion to within +or-0.045 dB from DC through 0.41 f/sub s/ and an 11-tap design is given which compensates the D/A distortion to within +or-0.028 dB from DC through 0.045 f/sub s/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Implementing a dynamically reconfigurable ATM switch on the VIRTEX FPGA of the FPX platform (2002)

This paper shows how a reconfigurable ATM switch (RECATS) has been implemented on a single VIRTEX FPGA, present in the Field Programmable Port Extender board (FPX). The switch architecture is outlined and the FPX platform is described in detail. Finally, the modifications applied to the FPX components and the methodology used to validate the reconfigurable switch are explained.
Enho Mutations Causing Low Adropin: A Possible Pathomechanism of MPO-ANCA Associated Lung Injury (2016)

Our findings indicate that the presence of Enho mutations or adropin-deficiency is a probable molecular basis for the initial events triggered in MPO-ANCA associated lung injury.
Lymphangiogenesis in gastric carcinoma correlates with prognosis (2009)

Lymphatic metastasis is an important way that gastric carcinomas can spread. However, little is known about the mechanisms of lymphangiogenesis and its clinical significance in gastric carcinomas. In the present study, lymphatic vessel density (LVD), VEGF-C expression, and proliferative activity of lymphatic endothelium were determined in human gastric carcinomas and xenografts of gastric cancer cells in nude mice. The development of lymphangiogenesis and its correlation with patient prognosis were investigated. The results showed that lymphatic vessels were observed mainly in peripheral tumour tissue with significantly (p < 0.05) higher P-LVD (peri-tumoural-LVD) than I-LVD (intra-tumoural-LVD). The expression of VEGF-C was heterogeneous within tumours, with a significantly higher expression (immunostaining score) at the margin than at the tumour centre (p < 0.05). A significant correlation was found between VEGF-C expression at the margin (but not at the centre) and P-LVD (r = 0.72, p < 0.01). High proliferative activity of lymphatic endothelium was also observed in the peripheral tissues, with a significant correlation between proliferative activity of lymphatic endothelium and VEGF-C expression (p < 0.05). These data imply that the increased lymphatics may have been newly formed following stimulation by VEGF-C. High VEGF-C expression at the margin of gastric carcinomas could induce lymphangiogenesis in the peri-tumoural stroma and contribute to the increased P-LVD. The data from mice tumour xenografts also suggested that VEGF-C produced from the transplanted gastric carcinoma cells could induce lymphangiogenesis around them. In patients, VEGF-C expression at tumour margins was associated with nodal metastasis, lymphatic vessel invasion, poor recurrence-free survival, and poor overall survival, and could serve as an independent predictor for patients with gastric carcinoma.
NUTRIENT REGULATION OF CELL CYCLE PROGRESSION (2004)

Cell replication is tightly controlled in normal tissues and aberrant during disease progression, such as in tumorigenesis. The replication of cells can be divided into four distinct phases: Gap 1 (G1), synthesis (S), gap 2 (G2), and mitosis (M). The progression from one phase to the next is intricately regulated and has many "checkpoints" that take into account cellular status and environmental cues. Among the modulators of cell cycle progression are specific nutrients, which function as energy sources or regulate the production and/or function of proteins needed to advance cells through a replicative cycle. In this review, we focus on the roles of specific nutrients (vitamin A, vitamin D, iron, folic acid, vitamin B12, zinc, and glucose) in the control of cell cycle progression and discuss how insights into the mechanisms by which these nutrients modulate this process can be and have been used to control aberrant cell growth in the treatment of prevalent pathologies.
Laetrile — An Overview (1978)

The original theory in the 1920s on the mode of action of Laetrile is described along with the research that followed in light of this theory. For over 40 years, studies were conducted, using test animals, in an attempt to substantiate the theory. All of these studies have shown Laetrile does not preferentially kill cancer cells. In spite of these studies, the misconception persists that Laetrile prevents and cures cancer. The legal and socioeconomic implications of Laetrile are examined and the role of health education in combating this problem is explored.
Spontaneous polarization reversal and photorefractive effect in single-domain iron-doped lithium niobate crystals (1978)

Partial reversal of spontaneous polarization in iron-doped LiNbO3 crystals takes place at room temperature in an external field of 104 V cm−1, as proved by the Barkhausen effect. Similarly, the formation of an internal photorefractive field of 104 V cm−1 leads to partial ferroelectric switching in the illuminated region of crystal. The dependences of the number of Barkhausen jumps on the external and internal fields are in close agreement. In Eisen-dotierten LiNbO3-Kristallen findet teilweise Umkehr der spontanen Polarisation bei Zimmertemperatur in einem äußeren Feld von 104 V cm−1 statt, wie durch Barkhauseneffekt nachgewiesen wird. In ähnlicher Weise führt die Bildung eines inneren photorefraktiven Feldes von 104 Vcm−1 zu partiellem ferroelektrischem Schalten im belichteten Teil des Kristalls. Die Abhängigkeit der Zahl der Barkhausensprüngen vom äußeren und inneren Feld befinden sich in enger Übereinstimmung.
Growth of ZnO Nanostructures with Controllable Morphology Using a Facile Green Antisolvent Method (2010)

An environmentally friendly antisolvent approach, which involves only biocompatible chemicals and mild processing conditions, was developed to prepare various ZnO nanostructures including twin-cones and nanorods with controllable dimensions. The method was based on the dissolution of ZnO powders in a deep eutectic solvent (DES), followed by precipitation of ZnO nanostructures from the DES upon introduction of an antisolvent. It is the first example of the room temperature ionic liquid based antisolvent process for preparation of nanomaterials. Through suitably modulating the processing conditions, such as the ethanol content of the antisolvent and the injection time of the ZnO-containing DES, the morphology of the resulting ZnO nanostructures can be readily controlled. Anisotropic crystal growth was achieved without severe reaction conditions, such as high temperatures and high vacuums, or use of environmentally harmful chemicals, such as long carbon chain surfactants and capping reagents. The present method can be readily extended to produce versatile nanostructures of other functional materials.
Een opmerking over het aanpassen van functies aan een groot aantal waarnemingsuitkomsten (1954)

Summary Note on the fitting of a function to a large number of observations. The paper deals with various ways in which a set of functions may be chosen to describe a given body of observations, the parameters determining the function being determined by the data. The special case when the functions of the set are given in the form of a table or a graph is emphasized.
RIFLE-62: a flexible environment for prototyping dynamically reconfigurable systems (2002)

The paper presents RIFLE-62-a new FPGA based prototyping environment optimised for rapid prototyping of applications exploiting dynamically reconfigurable logic (DRL). RIFLE-62 has a highly flexible architecture based around the Xilinx XC6200 family of dynamically reconfigurable FPGAs. The RIFLE-62 experimental board further provides two additional FPGAs (XC4013E and XC3100A), large static and dynamic memory, 32 bit data and 24 bit address busses, control signals, dual clocks and four dedicated interfaces. The RIFLE-62 software environment provides easy access to hardware resources and allows their configuration via a parallel port or the PCI interface. RIFLE-62 was developed to support research in embedded DRL, reconfigurable computing, but also other DRL applications, such as self morphing and self reproduction automata.
Iminyls. Part 7. Intramolecular hydrogen abstraction; synthesis of heterocyclic analogues of α-tetralone (1981)

A. R. Forrester, R. J. Napier and R. H. Thomson, J. Chem. Soc., Perkin Trans. 1, 1981, 984 DOI: 10.1039/P19810000984
Psychological Impact on Parents of an Inconclusive Diagnosis Following Newborn Bloodspot Screening for Cystic Fibrosis: A Qualitative Study (2019)

Genetic results of uncertain clinical significance are being returned to parents following newborn screening, representing a paradigm change in how society considers health and illness. 'Cystic Fibrosis screen positive, inconclusive diagnosis' (CFSPID) is a designation given to newborns with a positive screening result for, but not a definitive diagnosis of, cystic fibrosis. We explored the psychological impact of receiving a CFSPID result on parents. Five semi-structured interviews were conducted with eight parents whose children have CFSPID. Interpretative phenomenological analysis identified these themes: "The way we were told": 'diagnosis as a traumatic event' focused on how parents were distressed and dissatisfied by the initial screening result communication, 'Facing and challenging traditional ideas about health and illness' explored the emerging problem of how CFSPID does not fit the commonly accepted medical model, and 'Making certainty out of uncertainty' explored the varying strategies parents developed to adapt to the uncertainty regarding their child's prognosis. Findings suggest that CFSPID results caused parents' distress, initiated with the first communication of the result and persisting thereafter. Our data suggests approaches to the delivery of CFSPID results that may reduce the impact. Work is needed to close the gap between healthcare advances and societies commonly held medical model.
Interactions of cimetidine and pirenzepine on peptone-stimulated gastric acid secretion in man. (1980)

Combinations of H2-receptor antagonists and classical anticholinergics inhibit stimulated gastric acid secretion more than either drug alone. In double blind, placebo controlled, randomised studies we have compared the effects of single and combined intravenous bolus injections of cimetidine and pirenzepine on peptone-stimulated acid secretion and serum gastrin in man. Combined injection of 3.0 mg/kg cimetidine and 0.3 mg/kg pirenzepine suppressed stimulated acid secretion significantly more than either drug alone, and by 90% in healthy volunteers (n = 8) and patients with duodenal ulcer (n = 5). Side-effects (prolactin stimulation, blurred vision) were diminished by reducing the combined dosages to 1.5 mg/kg cimetidine, to 0.075 and 0.15 mg/kg pirenzepine in another series (n = 10). Postprandial gastrin was not affected by any combination. Combination of cimetidine and pirenzepine suppress food-stimulated gastric secretion more effectively than combination of H2-blockers with classical anticholinergics. Pirenzepine--unlike classical anticholinergics--may distinguish between different subclasses of muscarinic receptors and have a more selective antimuscarinic action. Its interaction with H2-receptor antagonists on parietal cell function seems to be synergistic. Such a combination could be of advantage in patients with gastrinoma, in patients with ulcers and hypersecretion resistant to single drug treatment, and in critically ill patients as prophylaxis of stress ulcer bleeding.
Formation and Characteristics of the Low Dielectric Carbon Doped Silicon Oxide Thin Film Deposited by MTMS/O<sub>2</sub> – ICPCVD (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Mesoporous carbon with uniquely combined electrochemical and mass transport characteristics for polymer electrolyte membrane fuel cells (2012)

The design of electrodes for polymer electrolyte membrane fuel cells (PEMFCs) is a delicate balance of electrochemical and mass transport issues. High performance fuel cell electrode materials require nanoarchitectures with established nanoscopic reaction zones and efficient molecular transport of gas- or liquid-phase reactants and products to and from the electrochemical reaction zones. Mesoporous carbon (MC), with uniquely combined electrochemical and mass transport characteristics is an ideal electrode material for polymer electrolyte membrane fuel cells as its mesoscopic structures not only enables electrocatlysts to be highly dispersed, but also offers ideal pore morphologies that facilitate mass transport. Recently, a wide variety of applications of MCs in PEMFCs have been exploited. This article provides a review of these past efforts with an attempt to gain a better understanding of the role of MCs in PEMFCs. The contribution of MCs in the gas diffusion layer is addressed first and their roles in the catalyst layer are then discussed. The advantages and disadvantages, the acting mechanism to promote electrochemical and mass transport characteristics, and the strategies to improve present electrode materials are discussed.
Microwave-assisted Solvothermal Synthesis of Bis(nicotinate)zinc (2011)

Bis(nicotinate)zinc was successfully synthesized in 10 min under microwave-assisted solvothermal condition,the influences of reaction time,temperature,solvent,substrate concentration and heating method on the crystallization of the complexes were disscussed.Microwave heating not only shorten the reaction time significantly and improve the yield and purity of product,but also has good reproducibility and stability of the amplification.The combination of the microwave-assisted solvothermal method and the conventional solvothermal method not only has the advantages of microwave heating,but also can obtain crystals with large particle size that suitable for structural analysis.
Do cooking fuels pose a risk for lung cancer? A case-control study of women in Hong Kong. (1983)

Two hundred female lung cancer patients and 200 female district controls in Hong Kong were interviewed about their previous use of various types of cooking fuels to assess whether any association could be found with lung cancer risk. Mixed results were found when the data were analyzed in terms of ever-exposed vs never-exposed duration, and relationship with smoking. Cases were found to have slightly more exposure to kerosene, whereas controls were likely to have used the cleaner, but more expensive, liquid petroleum gas (LPG) type of fuel. Because the evidence was conflicting if evaluated in terms of consistency, strength, specificity, and coherence of the associations, it was concluded that the small differences in exposure levels between the cases and controls probably reflected their socio-economic circumstances rather than risk for lung cancer. No interaction effect was found between kerosene exposure and smoking.
Characterization of a putative nitric oxide synthase in the neuromuscular system of the parasitic nematode, <i>Ascaris suum</i> (2001)

In this paper we report on the biochemical presence of nitric oxide synthase (NOS)-like activity in Ascaris suum tissue and examine the pharmacological effect of NO donors on A. suum muscle strip preparation. NOS activity was determined by monitoring the formation of [3H]citrulline from [3H]L-arginine and NO formation via the oxyhaemoglobin assay. Neuromuscular tissue from A. suum which stained positively for NADPH diaphorase, contained NOS activity. Neither NOS activity nor NADPH diaphorase staining was detected in intestinal tissue. The absence of Ca2+, NADPH and other co-factors normally required for mammalian neuronal NOS activity only partially reduced the formation of both citrulline and NO by A. suum neuromuscular homogenate. The results of the biochemical assays indicate the presence of an enzyme capable of producing NO and citrulline, but with a different profile from that of rat neuronal NOS. We also present preliminary evidence for the action of NO (NO donors) in the neuromuscular system of A. suum.
IDENTITY AND GLYCOGEN-FERMENTING ABILITY OF LACTOBACILLI ISOLATED FROM THE VAGINA OF PREGNANT WOMEN (1969)

SUMMARY Thirty-two strains of lactobacilli were isolated from the healthy vaginas of pregnant women and 10 strains from the vaginas of pregnant women with a vaginal discharge due to candida infection. Of these 42 strains, 11 were Lactobacillus acidophilus, 2 were L. brevis, 6 were L. casei, 12 were L. fermentum, 1 was L. lactis, 5 were L. leichmannii, and 5 were L. salivarius. Whereas only 1 strain of L. acidophilus split oyster glycogen, human vaginal glycogen was split by 2 wild strains and 2 laboratory strains of L. acidophilus, 1 laboratory strain of L. leichmannii and 1 wild strain of L. salivarius.
Laser systems and applications (1967)

La Real Academia Nacional de Medicina de España, cuya historia comienza hacia mediados del siglo XVIII, posee una magnífica biblioteca con manuscritos e impresos, indispensables para el estudio e investigación de la historia de la medicina en España. Para dar la mayor visibilidad posible y hacerlo accesible a los estudiosos, investigadores y ciudadanos en general, se crea esta Biblioteca Digital de la Real Academia Nacional de Medicina de España.
Spatiotemporal control of polymer brush formation through photoinduced radical polymerization regulated by DMD light modulation (2019)

Spatially arranged polymer brushes provide the essential capability of precisely regulating the surface physicochemical and functional properties of various substrates. A novel and flexible polymer brush patterning methodology, which is based on employing a digital mirror device (DMD)-based light modulation technique to spatiotemporally regulate a surface-initiated photoinduced atom transfer radical polymerization (photo-ATRP) process, is presented. Various characterization techniques confirm that the spatially and/or temporally controlled brush formation results in complex PEG-derived brush patterns in accordance with a customized digital image design. A series of step-and-exposure strategies, including in situ multiple exposure, dynamic multiple exposure and dynamic sequential exposure, are developed to implement spatiotemporal regulation of the photo-ATRP process, leading to complex patterned and gradient brushes featuring binary functionalities, pyramid nanostructures and radial directional chemical gradients. Moreover, tunable and radial directional concentration gradients of various biomacromolecules (e.g., streptavidin) are obtained through preparation of height gradients of azido-functionalized brushes and subsequent orthogonal chemical activation aimed at specific protein immobilization. Finally, a unidirectional concentration gradient of fibronectin, surrounded by non-fouling PEG brushes, is fabricated and applied for human umbilical vein endothelial cell (HUVEC) adhesion experiments, whose preliminary results indicate gradient-dependent cell adhesion behavior in response to the concentration gradient of fibronectin. The presented fabrication technique could be integrated with microfluidic devices for sensors and bio-reactors, paving the way for novel approaches for lab-on-a-chip technologies.