gebhart/patrepeval huggingface dataset:
Recovery of Axonal Transport after Partial Optic Nerve Damage Is Associated with Secondary Retinal Ganglion Cell Death In Vivo (2012)

After damage many surviving RGCs lose their axon transport, but after approximately 3 weeks, this transport recovers again, a sign of intrinsic axon repair. Contrary to the prediction, axon transport recovery is not associated with better cell survival but rather with a second wave of cell death. Thus, the accelerated cell death associated with recovery of axon transport suggests the existence of a late retrograde cell death signal.
A791. THE RATIONALE AND VALIDATION OF AN AUTOMATED WEB-BASED ELECTONIC DATA CAPTURE RADIOGRAPHIC MEASUREMENT TOOL (2011)

The trend toward evidence-based decision-making in orthopedics requires the analysis of large sets of data in real time that can direct clinical decision-making. We have developed an automated web-based electronic data capture (EDC) software system designed to simplify and make more time and cost efficient orthopedic data collection and analysis. The purpose of this study is to validate the radiographic alignment tool of the EDC software system. The goal was to establish the feasibility of using this web-based EDC tool in clinical practice. Twenty-eight consecutive unilateral TKAs were performed on 28 patients. Coronal mechanical axis and sagittal tibial and femoral axis radiographic measurements were obtained preoperatively and 1 month postoperatively. The radiographs were uploaded to a web-based EDC knee surgery data analysis program that includes a radiographic measurement tool. Two blinded observers analyzed the radiographs; one using a conventional manual measurement tool and the other a web based measurement tool. A paired t-test was used to evaluate measurement variation between observers. There was no statistically significant difference in pre-operative mechanical axis (.18°, p>.05), postoperative mechanical axis (.25°, p>.05), postoperative femoral component axis (.68°, p>.05), and postoperative tibial component axis (1.07°, p>.05) measurements performed using the manual tool and the web-based software systems. The results of this study validate the ability of the web-based software system to collect and process radiographic measurements. An automated web-based EDC software system allows for the full integration of patient demographic, radiographic, and peri-operative clinical variables in a fully searchable, instantaneously updatable and easily analyzed database. It is anticipated that this unique approach will allow surgeons to gather a wealth of searchable and quantifiable data that can quickly, accurately, economically, and efficiently shape clinical decisions.
High-Resolution Dual-Trap Optical Tweezers with Differential Detection: Managing Environmental Noise: Figure 1. (2009)

Optical traps or "optical tweezers" have become an indispensable tool in understanding fundamental biological processes. The ability to manipulate and probe individual molecules or molecular complexes has led to a new, more refined understanding of the mechanical properties of the fundamental building blocks of the cell, and of the mechanism by which molecular machines function. The minimization and management of noise are the keys to building a high-resolution optical tweezers. The high degree of stability needed to observe angstrom motions of a biological system places rather stringent requirements on the environment in which the instrument operates. Specifically, environmental noise is a concern when it leads to differential movements of the optical trap relative to the second attachment point of the tether. In this article, we discuss what entails a quiet environment--what sources of noise are relevant and how they affect the instrument--and provide guidelines for choosing an appropriate location for a high-resolution instrument.
Demand Loading Analysis for a 3X NextGen Future (2007)

A demand loading analysis for a future 3X demand set was conducted in order to evaluate the impact of future Next Generation Air Transportation System (NextGen) system requirements, Future, unconstrained demand loading for both National Airspace System (NAS) airports and airspace were analyzed using airport and airspace demand-to-capacity metrics resulting from the output of a future demand generation tool. The potential impact of both capacity-increasing concepts and potential demand changes were evaluated. The results suggest that 3X demand sets represent very demanding scenarios for future ATM concepts and that expected heterogeneous demand growth will result in required improvements to NextGen local airport and airspace capacities that are significantly greater than 3 times current levels.
Time-Kill Assay Results for a Linalool-Hinokitiol-Based Eyelid Cleanser for Lid Hygiene (2010)

This linalool-hinokitiol-based eyelid cleanser may be helpful in the outpatient setting for patients with presurgical, blepharitis, punctal plug and dry eye, and in the inpatient setting for patients who are allergic to iodine, or as an adjunct to povidone-iodine.
A comparative structural study in monolayers of GPI fragments and their binary mixtures (2014)

Glycosylphosphatidylinositols (GPIs), natural complex glycolipids essential for a range of biological functions, are poorly understood with regard to their interactions and arrangements in cellular membranes. To evaluate the role of the head group in the structure formation in 2D model membranes (monolayers formed at the soft air/liquid interface), we employed the highly surface sensitive grazing incidence X-ray diffraction technique to investigate three GPI-fragments bearing the same hydrophobic part but different head groups. Condensed monolayers of simple GPI fragments are defined only by ordered alkyl chains. The monolayers of more complex fragments are additionally characterized by highly ordered head groups. Due to the strong H-bond network formed by the head groups, GPI-fragment both segregates and induces order into a model membrane phospholipid (POPC) that mimics the liquid-disordered phase of cell membranes. Here, we show that the strong van der Waals interactions between hydrophobic chains overcome the head group interactions and dominate the structure formation in mixtures of GPI-fragment with lipids that form liquid-condensed phases. This behaviour can be linked to the GPIs affinity for the lipid rafts.
Single-shot Characterization of sub-15fs Pulses with 40dB Dynamic Range (2011)

We present an extended version of the self-referenced spectral interferometry technique which allows for both spectral phase and intensity retrieval from a single-shot interferogram. Sub-15fs pulses are characterized by SRSI and feedback experiments demonstrate >40dB dynamic range.
MIMO-SAR and the orthogonality confusion (2012)

This paper reviews radar architectures that employ multiple transmit and multiple receive channels to improve the performance of synthetic aperture radar (SAR) systems. These advanced architectures have been dubbed multiple-input multiple-output SAR (MIMO-SAR) in analogy to MIMO communication systems. Considerable confusion arose, however, with regard to the selection of suitable waveforms for the simultaneous transmission via multiple antennas. In this paper, it is shown that the mere use of orthogonal waveforms is insufficient for the desired performance improvement in view of most SAR applications. As a solution to this fundamental MIMO-SAR problem we had previously suggested to exploit the special data acquisition geometry of a side-looking imaging radar equipped with multiple receiver channels in addition to appropriately designed waveforms transmitted by multiple antennas. Here, we extend this approach to a more general set of radar waveforms with special correlation properties that satisfy a short-term shift-orthogonality condition. We show that the echoes from simultaneously transmitted pulses can be separated if the short-term shift orthogonality is combined with digital beamforming on receive in elevation. This enables the implementation of a fully functional MIMO-SAR without correlation noise leakage for extended scattering scenarios.
Revolutionary Advances in Skin Stapling: A Collective Review (2001)

The purpose of this article is to provide a collective review of the literature on skin staplers. On the basis of this review, the Auto Suture Multifire Premium, with its regular and wide metal staples, is recommended for skin closure. The Auto Suture Multifire Graftac-S is ideally suited for skin-graft fixation, because it delivers an absorbable staple that usually does not have to be removed from the healing graft. Dermal skin closure can now be achieved using the Auto Suture SQS-20, which coapts the cut dermal edges with an absorbable straight pin. Dermal wound approximation can be accomplished in significantly less time than dermal suture closure.
Primary Pulmonary Hypertension With Central Sleep Apnea (2000)

An obese 23-year-old man with sleep-disordered breathing and primary pulmonary hypertension (PPH) had been administered oral beraprost sodium, anticoagulant warfarin, and home oxygen therapy, at another hospital as treatment for the PPH, but he had not experienced any symptomatic improvement. The patient had a body mass index of 32.4kg/m2, and complained of fatigue, shortness of breath on exertion, excessive daytime sleepiness, and snoring. Arterial blood gas analysis showed a PaO2 and a PaCO2 of 70.9 and 31.2mmHg, respectively. A polysomnographic study revealed central sleep apnea with an apnea-hypopnea index (AHI) of 29.7episodes/h. The patient showed improvement of daytime sleepiness after starting nocturnal nasal bilevel positive airway pressure (BiPAP) therapy for the central sleep apnea, but his pulmonary hypertension, measured in the daytime, worsened. The patient died suddenly while walking to the bathroom in the morning 1 month after initiation of BiPAP therapy. It is necessary to consider the possibility of sudden death when nasal BiPAP therapy is given to a PPH patient with central sleep apnea.
27 Contrast induced acute kidney injury – a five year review (2019)

<h3>Introduction</h3> Contrast induced acute kidney injury (CI-AKI), currently defined as a delta rise in serum creatinine of ≥26.5 µmol/litre or a relative rise of ≥50% from baseline measured at 48 hours following administration of iodinated contrast media, is reported to complicate almost 20% of studies in high-risk individuals1. As previously presented, we implemented a formalised protocol for the management of chronic kidney disease (CKD) patients in our cardiac catheterisation laboratory2–3. This included clear pre and post-hydration guidance, use of the Mehran score to identify high-risk patients, ensuring nephrotoxic medications were withheld and use of advice sheets for patients and GPs. With this we achieved an 8.9% reduction in the rates of CI-AKI for patients with CKD. This study highlights a five-year re-audit of CI-AKI rates. <h3>Methods</h3> During the period between August 2018 and February 2019, a total of 2025 patients underwent contrast angiography ± percutaneous coronary intervention (PCI) at our institution. Of these, 266 (11.1%) had CKD. All patients with an estimated glomerular filtration rate (eGFR) ≤60 mls/min/m<sup>2</sup> presenting for coronary angiography at our laboratory were included. Data were obtained from lab reporting systems and from the Northern Ireland electronic care record. Demographics, risk factors and renal function before and at 48 hours post angiogram were recorded. Mehran scores were calculated for each patient and pre/post procedure intravenous fluids prescribed if appropriate. CI-AKI was defined as a delta rise in serum creatinine of ≥26.5 µmol/litre or relative rise of ≥50%. Case report forms were used to record blood results. Patients were telephoned at 48 hours and advised to restart withheld nephrotoxic medications if appropriate or, if necessary, given AKI advice with repeat blood sampling a further 48 hours later. Data were non-parametric on Shapiro-Wilk testing therefore Mann-Whitney U test (p<0.05 as significant) was applied for continuous variables. Chi squared test was applied for categorical variables (p<0.05 as significant). <h3>Results</h3> Of the 266 patients identified, 22 (8.3%) developed CI-AKI 48 hours post-contrast. Using the previous definition of CI-AKI at the time of our initial study in 2014 (creatinine rise ≥25%), 11 patients (4.1%) developed CI-AKI which remains well below the published literature rate of 10–15%. Average Mehran scores were significantly higher in those patients that went on to develop CI-AKI compared with those that did not (14 vs. 10, p<0.001, table 1). <h3>Conclusion/Implications</h3> Our comprehensive protocol for the peri-angiography management of CKD patients has achieved a significant reduction in the rates of CI-AKI at our institution, which has been sustained over a five-year period. There is a statistically significant correlation between higher Mehran score and development of CI-AKI, indicating the value of this tool as a surrogate marker for high-risk patients.
Feasibility of determination of low-head hydroelectric power development at existing sites. Big Blue River Co-dependent Hydroelectric Development: feasibility study (1979)

The technical, economic, environmental, safety, and financial aspects of redeveloping 7 dam sites in Nebraska for hydroelectric power generation were studied. The Big Blue River Co-dependent Hydroelectric Development was found to be a technically feasible concept, for both redevelopment and in some cases rehabilitation of seven existing sites. The proposed redevelopment project will include seven installations with a recommended nominally rated redeveloped capacity of 3920 kW ranging from 120 kW at the northernmost site in Seward County to 1500 kW at Barneston. The average annual gross generation expected from the seven redeveloped sites totals 11,555,000 kWh. It is estimated that the total cost of redevelopment of these seven sites will be $14,090,000 at 1979 price levels, providing power at an average levelized cost of about 5.3 cents per kWh based on 7% cost of money, a mid-1983 commissioning date, and allowing for funds during construction and cost escalation over a 30-year period. Rehabilitation of original installations at Crete, Dewitt, Blue Springs and Barneston is technically feasible for a total installed capacity of 1415 kW with annual average gross generation of 6,675,000 kWh. The total cost of this rehabilitation is estimated as $3,372,000 at 1979 price levels, or about 2.4 cents per kWh, levelized on a similar basis. Rehabilitation of the Barneston site alone for an installed capacity of 760 kW and annual generation of 3,581,000 kWh is both technically and economically feasible. The total estimated cost of this alternative is $668,000, providing power at a cost of about 1.9 cents per kWh at 1979 price levels. The benefit-cost ratio for Barneston rehabilitation is estimated as 1.23.
Electrical, thermal, and photo properties of poly(phenylene vinylene) precursors. II. Microwave‐induced elimination reactions in precursor polymer films (1994)

Abstract Microwave radiation (MWR) was used to induce the elimination reaction of the poly(phenylene vinylene)–polyelectrolyte precursors polymer (PPV precursor) into the fully conjugated polymer. The process was applied mainly to the unsubstituted PPV and was followed by infrared spectroscopy. The extent of the elimination process was also determined from the amount of residual sulfur in the film after the irradiation process. The microwave‐induced elimination process was also attempted using PPV precursor films that had been impregnated with anionic compounds containing iron. The molecular mechanisms for the observations are discussed and comparison with the elimination reaction induced by other energy sources is also made. © 1994 John Wiley & Sons, Inc.
Structure determination of natural and recombinant globular domain of histone H1 by high frequency NMR (1992)

info:eu-repo/semantics/published
Analysis and optimization of the recessed probe launch for high frequency measurements of PCB interconnects (2008)

Measurements of internal printed circuit board (PCB) structures such as striplines and vias face the problem of launching clean test signals into the device under test (DUT). Traditionally, coaxial connectors or surface probing with high frequency microprobes are used to provide interfaces to test equipment. Both approaches have to be carefully optimized in order to give adequate results for the multi-GHz range. This paper discusses a different access technique, the recessed probe launch (RPL), which was previously used by the authors for measurements up to 40 GHz. Full-wave 3D electromagnetic modeling is applied to analyze the parasitics of the proposed launch technique and to find strategies for its optimization. Comparison to measurement shows that the models are able to predict the major physics of the launch but several details still need to be explored, e.g. accurate modeling of the microprobes, material parameters, and network analyzer calibration.
<title>L-band erbium-doped silica fibers and their applications</title> (2001)

High concentration erbium-doped silica fibers were developed for amplification of L-band optical signals. Power conversion efficiency as a function of erbium-doping concentration for various erbium-doped silica fibers was analyzed and characterized at a wavelength of 1585 nm and at a pump wavelength of 1480 nm by using a two-stage amplifier and a C-band ASE filter. The experimental results are consistent with the simulation results. High Al doping and optimization of NA and erbium-doped region can help reduce the pair-induced quenching effects and improve the efficiency.
Theory of relaxation processes in superconductors (1976)

Equations describing the relaxation of electron and phonon temperature, the effective chemical potential of quasiparticles, and the energy gap are analyzed on the basis of the kinetic equations for electrons and phonons in superconductors as well as the equation for the nonequilibrium-order parameter which the authors have derived in an earlier study. The corresponding relaxation times are also calculated.
Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes (2000)

We recently reported increased sensitivity of B-cell chronic lymphocytic leukemia (B-CLL) lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin. Here, we show that only specific—not nonspecific—proteasomal inhibitors can discriminate between malignant and normal lymphocytes in inducing the apoptotic death response. Indeed, lactacystin and its active metaboliteclasto-lactacystin β-lactone induced apoptotic death in CLL but not in normal lymphocytes. This difference was completely abolished when tripeptide aldehydes such as MG132 or LLnL (which can also inhibit calpains) were used as less specific proteasomal inhibitors. Moreover, B-CLL cells exhibited a constitutive altered ubiquitin-proteasome system, including a threefold higher chymotrypsin-like proteasomal activity and high levels of nuclear ubiquitin-conjugated proteins compared with normal lymphocytes. Interestingly, B-CLL cells also displayed altered proteolytic regulation of wild-type p53, an apoptotic factor reported to be a substrate for the ubiquitin-proteasome system. Nuclear wild-type p53 accumulated after lactacystin treatment used at the discriminating concentration in malignant, but not in normal, lymphocytes. In contrast, p53 was stabilized by MG132 or LLnL in malignant and normal cells undergoing apoptosis, indicating that in normal lymphocytes p53 is regulated mainly by calpains and not by the ubiquitin-proteasome system. This work raises the possibility that two different proteolytic pathways controlling p53 stability may be pathologically imbalanced. This could result in modification of apoptosis control, since in CLL-lymphocytes a highly upregulated ubiquitin-proteasome system, which controls p53 stability among other apoptotic factors, was correlated with an increased propensity of these cells to apoptosis triggered by lactacystin.
Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus (2003)

The expression of CD22L is differentially regulated in B and T cells, and high expression of CD22L on circulating B cells is a marker for development of severe SLE, suggesting a role for CD22-CD22L interactions in SLE as well as in the regulation of humoral immunity.
New Copper Chemistry. 25. Effect of TMSCl on the Conjugate Addition of Organocuprates to .alpha.-Enones: A New Mechanism (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Copper Chemistry. 25. Effect of TMSCl on the Conjugate Addition of Organocuprates to .alpha.-Enones: A New MechanismSteven H. Bertz, Guobin Miao, Bryant E. Rossiter, and James P. SnyderCite this: J. Am. Chem. Soc. 1995, 117, 44, 11023–11024Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ja00149a032https://doi.org/10.1021/ja00149a032research-articleACS PublicationsRequest reuse permissionsArticle Views1476Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Treatment of rheumatoid arthritis patients with abatacept and methotrexate significantly improved health-related quality of life. (2006)

After 12 months of treatment, patients randomized to abatacept 10 mg/kg showed significantly better HRQOL outcomes overall versus patients randomized to placebo (MANOVA F = 4.71, p < 0.001) or to abatacept 2 mg/kg (MANOVA F = 1.97, p = 0.05). Differences in SF-36 change scores between abatacept 10 mg/kg and placebo groups reached statistical significance on all 8 domain scales, the 2 summary measures, and the SF-36 utility index (SF-6D). Differences in SF-36 change scores between abatacept 10 mg/kg and abatacept 2 mg/kg reached statistical significance on 5 of the 8 domain scales, the physical summary measure, and the SF-6D. Improvement in HRQOL was highly related to clinical response. CONCLUSION Abatacept 10 mg/kg plus MTX demonstrated a stronger HRQOL response than placebo plus MTX. The abatacept 2 mg/kg arm showed a very weak and transient response.
Chirping regenerative amplifier with dispersive optics (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Kawanaka, H. Furuse, T. Kawashima, and H. Kan, "Chirping regenerative amplifier with dispersive optics," in Lasers, Sources, and Related Photonic Devices, OSA Technical Digest (CD) (Optical Society of America, 2012), paper AT4A.19. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article