gebhart/patrepeval huggingface dataset:
Differential effects of PXD101 (belinostat) on androgen-dependent and androgen-independent prostate cancer models (2011)

Histone deacetylase inhibitors (HDACi) are promising epigenetic cancer chemotherapeutics rapidly approaching clinical use. In this study, we tested using in vitro and in vivo models the differential biological effects of a novel HDAC inhibitor [belinostat (PXD101)], in a wide panel of androgen-sensitive and androgen-independent tumor cells. Belinostat significantly increased acetylation of histones H3 and H4. Belinostat potently inhibited the growth of prostate cancer cell lines (IC50 range from 0.5 to 2.5 µM) with cytotoxic activity preferentially against tumor cells. This agent induced G2/M arrest and increased significantly the percentage of apoptosis mainly in androgen-sensitive tumor cells confirming its growth-inhibitory effects. The cell death mechanisms were studied in three different prostate cancer cell lines with different androgen dependence and expression of androgen receptor; LAPC-4 and 22rv1 (androgen-dependent and expressing androgen receptor) and PC3 (androgen-independent not expressing androgen receptor). Belinostat induced the expression of p21 and p27, acetylation of p53 and G2/M arrest associated with Bcl2 and Bcl-Xl downmodulation and significant reduction of survivin, IAPs and Akt/pAkt and increased caspase-8 and -9 expression/activity. Belinostat effectiveness was dependent on the androgen receptor (AR), since the stable transfection of AR greatly increased the efficacy of this HDAC inhibitor. These observations were correlated using in vivo models. We demonstrated that belinostat preferentially resulted in antitumor effect in androgen-dependent tumor cells expressing AR. Our findings provide evidence that belinostat may be a promising anticancer drug for prostate cancer expressing AR, supporting its clinical role in prostate cancer.
IC‐P‐068: Replication and meta‐analysis of the CHRFAM7A copy number variant in a cohort of clinically characterized and neuropathologically verified individuals (2012)

Copy number variations (CNVs) are DNA regions >1 kilobase in size that have added (duplications) or deleted (deletions) genetic material. They may encompass genes affecting their function and resulting in disease. Previously, we investigated the role of CNVs in late-onset AD and MCI using ADNI [1] and NIA-LOAD/NCRAD Family Study [2] participants, and identified a number of genes overlapped by CNV calls. To confirm the findings and identify other possible candidate regions, we analyzed a unique cohort of clinically characterized and neuropathologically defined individuals [3]. CNV calls were generated in PennCNV software for 1617 Caucasian participants (1022 AD and 595 controls) with DNA extracted from brain tissue. After extensive quality control, 1166 samples (728 AD and 438 controls) were analyzed using PLINK software in a case/control association design. Genes overlapped by CNV calls only in cases (AD) were identified. Meta-analysis of the CHRFAM7A gene findings from the three studies was performed using MetaAnalyst and Comprehensive Analysis software. Molecular validation of the APp gene finding was performed using quantitative real-time PCR. AD samples showed a trend toward a higher CNV call rate for deletions and duplications than controls. Case/control association identified previously reported genes including CHRFAM7A, overlapped by CNV calls in 22 AD participants and three controls in this study (Figure 1(a); Table 1). Meta-analysis indicated a significant association of CHRFAM7A with AD and/or MCI risk (Odds Ratio = 3.986; 95% Confidence Interval, 1.490-10.667; p = 0.006). One AD sample (APOE E2/E3 genotype, age at death = 67) had a novel APp gene duplication (Figure 1(b)), validated using quantitative real-time PCR. Representative UCSC Genome Brower (March 2006) (NCBI36/hg 18) assembly) plots of CNV calls overlapping the CHRFAM7A (a) and APP (b) genes. Deletions are represented by red rectangles and duplications are represented by blue rectangles. CNV analyses in the present study identified a number of previously reported genes including CHRFAM7A. One sample with an APp gene duplication was also identified representing a novel finding since APp duplications have been associated with early- but not late-onset AD. Further investigation of the identified genes is warranted in independent and larger samples. References: 1. Swaminathan et al. Int J Alzheimers Dis 2011(2011);729478.2. Swaminathan et al. Curr Alzheimer Res (in press).3. Corneveaux et al. Hum Mol Genet 19(2010):3295-3301.
Dural Inflammation Model of Migraine Pain (1999)

The cause of migraine pain is controversial. One recently proposed theory is that migraine pain may originate from inflammation of the meninges, particularly the dural membranes that surround the brain. This theory proposes that, during a migraine, there is an idiopathic activation of trigeminal sensory afferents, resulting in nociceptive transmission to the CNS as well as the release of pro-inflammatory substances in the periphery, particularly the dura. Dural inflammation is thought to lower the nociceptive threshold of dural afferents and facilitate nociceptive transmission to the central nervous system. In the procedure described in this unit, trigeminal sensory afferents are activated by electrically stimulating the trigeminal ganglion. This stimulation causes trigeminal peripheral sensory afferents to depolarize, inflammatory substances to be released from these afferents, and dural inflammation to appear. Dural inflammation is quantified by measuring plasma protein extravasation. The basic protocol describes this model in rats, and the alternate protocol describes the analogous procedure in guinea pigs.
Study of Longitudinal-Joint Construction Techniques in Hot-Mix Asphalt Pavements (1996)

There is a need to identify suitable longitudinal-joint construction techniques for multilane, hot-mix asphalt pavements that can minimize or eliminate cracking at the joint and raveling adjacent to the joint. It is believed that the longitudinal cracks result primarily from the density gradient that is usually encountered across the joint. This density gradient can be attributed to low density at the unconfined edge when the first lane is paved and relatively high density at the confined edge when the adjacent lane is paved. Seven different longitudinal-joint construction techniques were used on I-25 in Colorado in 1994, including various rolling procedures to compact the joint, provision of a vertical face with a cutting wheel, and use of rubberized asphalt tack coat on the face of the unconfined edge. Two longitudinal-joint construction techniques were used on I-79 in Pennsylvania in 1994: the conventional technique (control) and the New Jersey–type wedge joint. The latter technique uses a 3:1 taper at the unconfined edge of the first lane. The face of the taper is heated with an infrared heater before the adjacent lane is placed. Pavement cores were taken on the joint and 305 mm (1 ft) away from the joint for density measurements in all experimental test sections. Different techniques for joint construction have been ranked on the basis of statistical analysis of all density data. Various joints were also evaluated visually by teams of at least four engineers in June 1995. The performance, or ranking, of the joints in both Colorado and Pennsylvania projects after one winter seems to have been influenced by the overall density at the joint. The joints with high densities indicate better performance than those with relatively low densities. These rankings may change in the future on the basis of the long-term performance as measured by cracking and raveling.
Displacement Separation of Some of the Component Fatty Acids of Milk Fat (1957)

Nine fatty acids of milk fat, from butyric to stearic, were separated by displacement chromatography. This method appears to be adaptable to the separation of volatile and nonvolatile fatty acids by first saponifying the fat and then acidifying the soaps on the column just prior to carrier displacement analysis. Editor.
Moments generated by simple V-bends in nickel titanium wires (2010)

This study compared the moments produced by V-bends placed in rectangular nickel titanium (NiTi) orthodontic wire to those produced in titanium-molybdenum alloy (TMA). V-bends that included angles of 135, 150, and 165 degrees were heat set into 0.017×0.025 and 0.016×0.025 inch NiTi alloy wires and identical bends bent into TMA wires with a dimension of 0.018×0.025 and 0.016×0.022 inch. There were five specimens per group (N=60). The moments produced by each specimen were tested on a custom jig that aligned two lower incisor brackets with zero tip or torque at an interbracket distance of 15 mm. The upper bracket was connected to a moment transducer. The V-bend position for each specimen was varied in 1 mm increments towards the moment transducer. The moments produced by TMA wires were linear, which increased as the V-bend approached the transducer, while NiTi exhibited a non-linear curve characterized by a flattening of the moment value. The point of dissociation (where the moment experienced by the bracket became zero) was estimated for both wire types using linear mixed model analysis. For TMA wires, this point was similar to that reported in the literature but was significantly less for NiTi wire when compared with TMA. The moments produced by TMA generally increased with the magnitude of the V-bend, whereas this was not the case for NiTi.
Nucleophilic Substitution of Oxazino-/Oxazolino-/Benzoxazin [3,2-<i>b</i>]indazoles: An Effective Route to 1<i>H</i>-Indazolones (2010)

A variety of nucleophiles, thiolates, alkoxides, amines, iodide, and cyanide, react with oxazino-, oxazolino-, and benzoxazin[3,2-b]indazoles under microwave conditions to yield a diverse set of 2-substituted 1H-indazolones. The synthetic utility of these indazoles is further demonstrated by ANRORC (addition of the nucleophile, ring-opening, and ring closure) reactions to yield isomeric pyrazoloindazolones by a process wherein iodide acts first as a nucleophile and subsequently as a leaving group.
ChemInform Abstract: A Three‐Step Preparation of 3‐Isopropylcatechol. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sub-zero Treatment of Quenched Steel (1st Report). On the Effect of the Quenching Temperature and Room Temperature Aging on Sub-zero Treatment of Quenched Steel (1955)

Stee1(1st Report) On the Efect of the Quenching Temperature and Room Temperature Aging on Subzero Treatment of Quenched Stee1 This paper states the results of transformatioof the retained austenite to martesite isub-zero temperature raage as affected by q ueching temperature aad room temperature aging on ball-bearing steel cotaiing 102carbon and 135of chromium The results obtained are as folIows(1)
Development of a high power pulse THz gyrotron (2008)

We present results of modelling and details of fabrication of a pulse gyrotron to produce powers up to 10 kW peak and 10 W average at frequencies from 600 GHz to 2 THz. The gyrotron uses a pulse magnet that generates fields to 40 Tesla.
Saccadic Output Is Influenced by Limb Kinetics During Eye—Hand Coordination (2004)

In several recent studies, saccadic eye movements were found to be influenced by concurrent reaching movements. The authors investigated whether that influence originates in limb kinematic or kinetic signals. To dissociate those 2 possibilities, the authors required participants (N = 6) to generate pointing movements with a mass that either resisted or assisted limb motion. With practice, participants were able to generate pointing responses with very similar kinematics but whose kinetics varied in a systematic manner. The results showed that saccadic output was altered by the amount of force required to move the arm, consistent with an influence from limb kinetic signals. Because the interaction occurred before the pointing response began, the authors conclude that a predictive signal related to limb kinetics modulates saccadic output during tasks requiring eye-hand coordination.
La recepción de Vico en Ortega (1991)

espanolAl abordar el tratamiento orteguiano de Vico nos encontramos en lo que a la letra se refiere con dos hechos: por un lado, Ortega habla poco de Vico; por otro lado, Ortega habla de Vico. Este hablar mal hay que entenderlo tanto en sentido subjetivo como objetivo. Pero es asi que en lo referido al espiritu la confluencia orteguiana con Vico afecta a la medula del pensamiento de Ortega. Con lo cual se plantea que la recepcion orteguiana de Vico fue injusta. EnglishThe way Ortega deals with Vico proves two facts literally: a) Ortega speaks little about Vico; b) he expresses a bad opinion about him. However, as regards the spirit, of the confluence of Ortega with Vico affects Ortega's inner thoughts. Then it is understood that, either he did not read Vico's works and therefore his criticism would be illegitimate, or in fact he did not admit his intellectual debt fowards Vico. Ortega's admission of Vico's ideas was semehowe unfair.
Simple and Rapid Preparation of Samples for PCR (1989)

Sample preparation for PCR can be as simple and rapid as adding cells directly to the PCR.1 Things are not quite this easy, however, for all samples and applications of PCR. In this chapter, I will discuss what determines the amount of preparation necessary and present example protocols for the rapid preparation for PCR of DNA and RNA from various sources.
Latton priory (1879)

Journal Article Latton priory Get access Thomas Kerslake Thomas Kerslake 1Bristol Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s5-XI, Issue 263, 11 January 1879, Page 38, https://doi.org/10.1093/nq/s5-XI.263.38c Published: 11 January 1879
18. Étude de l'effet tunnel assisté par des impuretés dans le GaAs (1970)

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Erythrina Alkaloids. XVI. Studies on the Constitution of Erysodine, Erysovine and Erysopine (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTErythrina Alkaloids. XVI. Studies on the Constitution of Erysodine, Erysovine and ErysopineFrank. Koniuszy, Paul F. Wiley, and Karl. FolkersCite this: J. Am. Chem. Soc. 1949, 71, 3, 875–878Publication Date (Print):March 1, 1949Publication History Published online1 May 2002Published inissue 1 March 1949https://doi.org/10.1021/ja01171a031RIGHTS & PERMISSIONSArticle Views111Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (535 KB) Get e-Alerts Get e-Alerts
Risk factors in the pathogenesis of coronary artery disease. (1992)

In men, plaque rupture is strongly correlated with total cholesterol, and smoking is a predictor of acute thrombosis. In women younger than 50, plaque erosion correlates with smoking, whereas in women older than 50, thrombosis is secondary to plaque rupture and correlates with total cholesterol.
The K+ Channel KCa3.1 As A Novel Target For Idiopathic Pulmonary Fibrosis (2012)

Background: Idiopathic pulmonary fibrosis (IPF) is a common, progressive and invariably lethal interstitial lung disease with no effective therapy.We hypothesised that K Ca 3.1 K + channel-dependent cell processes contribute to IPF pathophysiology.Methods: K Ca 3.1 expression in primary human lung myofibroblasts was examined using RT-PCR, western blot, immunofluorescence and patch-clamp electrophysiology.The role of K Ca 3.1 channels in myofibroblast proliferation, wound healing, collagen secretion and contraction was examined using two specific and distinct K Ca 3.1 blockers (TRAM-34 and ICA-17043 [Senicapoc]).Results: Both healthy non fibrotic control and IPF-derived human lung myofibroblasts expressed K Ca 3.1 channel mRNA and protein.K Ca 3.1 ion currents were elicited more frequently and were larger in IPF-derived myofibroblasts compared to controls.K Ca 3.1 currents were increased in myofibroblasts by TGFβ1 and basic FGF.K Ca 3.1 was expressed strongly in IPF tissue.K Ca 3.1 pharmacological blockade attenuated human myofibroblast proliferation, wound healing, collagen secretion and contractility in vitro, and this was associated with inhibition of TGFβ1dependent increases in intracellular free Ca 2+ .Conclusions: K Ca 3.1 activity promotes pro-fibrotic human lung myofibroblast function.Blocking K Ca 3.1 may offer a novel approach to treating IPF with the potential for rapid translation to the clinic.
Fluorescence in situ hybridization shows spatial distribution of as yet uncultured treponemes in biopsies from digital dermatitis lesions (1998)

Fluorescence in situ hybridization (FISH) was performed on sections of plastic-embedded tissue using 16S rRNA-directed oligonucleotide probes to visualize uncultured treponemes in skin biopsies of cows with digital dermatitis. Plastic as embedding material allowed sectioning of hard and soft tissue with a defined thickness, avoiding the risk of dragging bacteria into the tissue while sectioning. furthermore, it provided a good signal-to-noise ratio. Using this method the spatial distribution of three different bacterial phylotypes was visualized simultaneously within the tissue. Whereas debris covering the ulcers contained a mixture of different micro-organisms, a layering of certain treponemal phylotypes was observed deeper in the epidermis. Confocal laser scanning microscopy and subsequent three-dimensional reconstruction of series of optical sections confirmed that the treponemes migrated intercellularly around the cells, most of them directed towards the dermis. In situ hybridization on tissue embedded in plastic proved to be a useful method to study mixed bacterial infections since it combines excellent histological conservation of tissue with identification of bacterial species by simultaneous use of probes labelled with different fluorescent dyes. This technique may have implications for in situ detection, identification and localization of microorganisms in veterinary as well as in human medicine.
Autonomic Provisioning and Application Mapping on Spot Cloud Resources (2015)

The spot instance model is a virtual machine pricing scheme in which unused resources of cloud providers are offered to the highest bidder. This leads to the formation of a spot price, whose fluctuations can determine customers to be overbid by other users and lose the virtual machine they rented. In this paper we propose a heuristic to automate the decision on: (i) which and how many resources to rent in order to run a cloud application, (ii) how to map the application components to the rented resources, and (iii) what spot price bids to use in order to minimize the total bid price while maintaining an acceptable level of performance. To drive the decision making, our algorithm combines a multi-class queueing network model of the application with a Markov model that describes the stochastic evolution of the spot price and its influence on virtual machine reliability. We show, using a model developed for a real enterprise application and historical traces of the Amazon EC2 spot instance prices, that our heuristic finds low cost solutions that indeed guarantee the required levels of performance. The performance of our heuristic method is compared to that of nonlinear programming and shown to markedly accelerate the finding of low-cost optimal solutions.
Bimodal distribution of tone-matching deficits indicates discrete pathophysiological entities within the syndrome of schizophrenia (2019)

To date, no measures are available that permit differentiation of discrete, clinically distinct subtypes of schizophrenia (SZ) with potential differential underlying pathophysiologies. Over recent years, there has been increasing recognition that SZ is heterogeneously associated with deficits in early auditory processing (EAP), as demonstrated using clinically applicable tasks such as tone-matching task (TMT). Here, we pooled TMT performances across 310 SZ individuals and 219 healthy controls (HC), along with clinical, cognitive, and resting-state functional-connectivity MRI (rsFC-MRI) measures. In addition, TMT was measured in a group of 24 patients at symptomatic clinical high risk (CHR) for SZ and 24 age-matched HC (age range 7-27 years). We provide the first demonstration that the EAP deficits are bimodally distributed across SZ subjects (P < 0.0001 vs. unimodal distribution), with one group showing entirely unimpaired TMT performance (SZ-EAP+), and a second showing an extremely large TMT impairment (SZ-EAP-), relative to both controls (d = 2.1) and SZ-EAP+ patients (d = 3.4). The SZ-EAP- group predominated among samples drawn from inpatient sites, showed higher levels of cognitive symptoms (PANSS), worse social cognition and a differential deficit in neurocognition (MATRICS battery), and reduced functional capacity. rsFC-MRI analyses showed significant reduction in SZ-EAP- relative to controls between subcortical and cortical auditory regions. As opposed to SZ, CHR patients showed intact EAP function. In HC age-matched to CHR, EAP ability was shown to increase across the age range of vulnerability preceding SZ onset. These results indicate that EAP measure segregates between discrete SZ subgroups. As TMT can be readily implemented within routine clinical settings, its use may be critical to account for the heterogeneity of clinical outcomes currently observed across SZ patients, as well as for pre-clinical detection and efficacious treatment selection.
Mechanical behavior and texture prediction of Ti-6Al-4V based on elastic viscoplastic self-consistent modelling (2015)

The goal of this study is to apply an elastic viscoplastic self-consistent crystal plasticity model to predict the texture evolution in a Ti-6Al-4V alloy which has a (mainly) hexagonal crystal structure. The model under consideration is an extension of the viscoplastic self-consistent model proposed by Lebensohn and Tome [1993] which has been adapted to account for elasticity and has been integrated with a new algorithm, making it more computationally efficient within an implicit FE scheme. The flow behavior of Ti-6Al-4V is strongly dependent on strain rate and temperature. To estimate the model parameters, the flow behavior of quasi-static experiments is used. A temperature sensitivity term has been introduced to correct the effects of temperature increase during the dynamic experiments. In order to have a meaningful rate sensitivity exponent, a value is calculated based on valid experimental data, rather than choosing an arbitrary large numerical value. In this way the behavior of Ti-6Al-4V is captured at different strain rates. Predictions of the model are compared to experimental data.