gebhart/patrepeval huggingface dataset:
Novel inhibitors of rat lens aldose reductase: N-[[(substituted amino)phenyl]sulfonyl]glycines (1987)

A number of N-[[(substituted amino)phenyl]sulfonyl]glycines 3a-n were synthesized as analogues of the simple (phenylsulfonyl)glycines 1a-c with increased lipophilic character and therefore greater aldose reductase inhibitory potential. The 2-benzoylamino derivative 3c was found to be less potent than the corresponding amine 1c as an inhibitor of rat lens aldose reductase, but both the 3- and 4-benzoylamino analogues, 3b and 3a, are substantially more potent than their amines 1b and 1a; compound 3a is the most effective inhibitor of this series, with an IC50 of 0.41 microM. The 4-benzoylamino derivative 3a is also significantly more active than the 4-acetylamino analogue 3d and the 4-benzylamino (3e) and 4-dimethylamino (3f) derivatives, suggesting that both the additional carbonyl moiety and aromatic ring present in this compound may bind to complementary sites present on the enzyme. Furthermore, structure-activity studies reveal that increasing the number of atoms between the carbonyl and aromatic moieties of 3a results in a decrease in inhibitory activity. Kinetic studies demonstrate that 3a, like other known inhibitors of aldose reductase, functions as an uncompetitive inhibitor with respect to the substrate and therefore may interact at the proposed common inhibitor binding site of this enzyme.
Selective and deep plasma etching of SiO2: Comparison between different fluorocarbon gases (CF4, C2F6, CHF3) mixed with CH4 or H2 and influence of the residence time (2002)

SiO 2 is a well suited material for integrated optic applications and is also attractive for microelectromechanical system and micro-optical electromechanical system fabrication. Such optical components require deep oxide etching (several microns) and subsequent high selectivity with respect to the mask. In this article, we describe the influence of various process parameters (gas mixture, pressure, plasma power, and residence time) on the selective etching of SiO2 with respect to Si in inductively coupled plasma (ICP) fluorocarbon with the aim of finding the best compromise between high selectivity and high oxide etch rate. Oxide etch rate is improved by decreasing pressure or increasing source power within the acceptable process windows, respectively, 3–20 mTorr and 1000–2000 W, but the gain in selectivity is low (×1.5). Adding methane rather than more commonly usual hydrogen resulted in higher selectivity without significant decrease in the oxide etch rate. A relatively good correlation is found between the selectivity and the (C+H)/F ratio of the precursor molecule. However, we show that varying the hydrofluorocarbon mixture does not allow us to improve both oxide etch rate and selectivity. In this regard, the residence time is the most significant parameter: choosing the appropriate amount of methane mixed with C2F6, and decreasing tR leads to an improvement in both the selectivity (×7) and the oxide etch rate (×1.5). Finally, the influence of these parameters on pattern transfer is investigated.
Intelligent Objects in Simulation (1994)

In this paper, learning automata are incorporated as decision making agents (“intelligent objects”) to handle the discrete type of decisions in simulation models. The integrated simulation system is viewed as a continuously evolving, closed system in which operational and design decisions can be made automatically. In this learning paradigm, the simulation model serves as an environment which provides performance evaluations for the decision policies formulated in succession by the learning automata. As the automata revise the action probabilities at regular intervals on the basis of these performance evaluations, they improve their decision making process continuously. The approach can be an excellent tool for the analysis and design of complex systems under uncertainty. An application is demonstrated in a manufacturing setting in which due-dates and machine assignments of jobs are the decisions to be made by the automata so as to minimize a nonlinear function of job tardiness and earliness subject to random job arrivals and machine breakdowns. INFORMS Journal on Computing, ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 to 1995 under ISSN 0899-1499.
A kinetic method for determining dissociation constants for metal complexes of adenosine 5'-triphosphate and adenosine 5'-diphosphate (1980)

A general kinetic method is described for determining the dissociation constants of metal-ATP complexes that act as inhibitory substrate analogues for any enzyme that utilizes MgATP(2-). The usefulness of the procedure is illustrated by the results obtained from studies of the inhibition of hexokinase by lanthanide-ATP (LnATP) complexes. At relatively low concentrations of Mg2+, these complexes act as linear competitive inhibitors with respect to MgATP(2-). In the presence of higher, fixed concentrations of Mg2+, however, double reciprocal plots of the inhibition by LnATP vs. MgATP are nonlinear, and the data can be used to determine the ratio of the dissociation constants for the LnATP and MgATP complexes. As values are available for the dissociation constant of MgATP under a variety of conditions, that for any LnATP complex can be calculated. The dissociation constant for EuATP at pH 8.0 is 0.16 microM, while that for GdATP is 0.91 microM at pH 6.0, 0.087 microM at pH 7.95, and 1 microM at pH 8.65. Between pH 6 and 8, the ratio of the dissociation constants for GdATP and MgATP(2-) remains constant, and thus, within this range of pH, the lanthanide species involved must be Gd3+ and GdATP-. The method can also be applied to the determination of dissociation constants for inhibitory metal-ADP complexes if MgADP- is used as the variable substrate.
Fiber optic sensors advance chemical analysis from afar (1994)

Practical fiber optic sensors, ready and able to measure such common variables as pressure, temperature, strain, and torque, now focus on a largely overlooked area: chemical applications. After a comparatively slow start towards commercialization, these sensors already tackle such tasks as measuring pH levels, and various other chemical changes. Compared with other sensor families, the advantages of fiber optic types are of course well known: immunity to EMI/RFI, high bandwidth, and the ability to work at high-temperatures. Fiber optic sensors will offer yet another major advantage for more demanding chemical applications: isolation from both electrical sources and from human contact/contamination with the sample under measurement. Indeed, the chief advantage of fiber optic sensors in chemical applications is their remote sensing capabilities for examining complex mixtures like blood serum, chemical process streams, and various natural waters. Other advantages include continuous monitoring of the analyte, and the ability to perform measurements in rugged field conditions. Moreover, the wide availability of fiber optics and related optoelectronic components have opened the door to sensors that are economically viable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automatic Classification Of Periodic Heart Sounds Using Convolutional Neural Network (2018)

This paper presents an automatic normal and abnormal heart sound classification model developed based on deep learning algorithm. MITHSDB heart sounds datasets obtained from the 2016 PhysioNet/Computing in Cardiology Challenge database were used in this research with the assumption that the electrocardiograms (ECG) were recorded simultaneously with the heart sounds (phonocardiogram, PCG). The PCG time series are segmented per heart beat, and each sub-segment is converted to form a square intensity matrix, and classified using convolutional neural network (CNN) models. This approach removes the need to provide classification features for the supervised machine learning algorithm. Instead, the features are determined automatically through training, from the time series provided. The result proves that the prediction model is able to provide reasonable and comparable classification accuracy despite simple implementation. This approach can be used for real-time classification of heart sounds in Internet of Medical Things (IoMT), e.g. remote monitoring applications of PCG signal.
Symmetry and the energy landscapes of biomolecules (1996)

The role of symmetry in the folding of proteins is discussed using energy landscape theory. An analytical argument shows it is much easier to find sequences with funneled energy landscape capable of fast folding if the structure is symmetric. The analogy with phase transitions of small clusters with magic numbers is discussed.
Influence of polar solvents on reaction dynamics: photoisomerization studies of dihydroxystilbene (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of polar solvents on reaction dynamics: photoisomerization studies of dihydroxystilbeneN. S. Park and D. H. WaldeckCite this: J. Phys. Chem. 1990, 94, 2, 662–669Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/j100365a029https://doi.org/10.1021/j100365a029research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Real Time Human Activity Recognition System based on Radon Transform (2011)

A real time human activity recognition system based on Radon transform (RT), Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) is presented. RT improves low frequency components and PCA provide global representation of these low frequency components in few eigenvectors. The proposed technique computes radon projections in different directions to obtain directional features of the images from video sequences. PCA is used to reduce the dimensions of radon shape features. LDA is applied on PCA features to provide better class separation. The aim is to develop a proficient recognition system in real time by the combination of local and global features. The dataset consisting of normal and abnormal activities is produced. Artificial Neural Nets (ANN) is used to recognize different human activities in real time. Experimental results show better recognition results for our system as compared to some state of the art methods.
Effect of acupuncture on myogenic headache (1977)

The purpose of the investigation was to study the effect of acupuncture on myogenic headache and to examine whether electromyographic recordings of jaw muscle activity would provide objective evidence of the effect of such treatment. In 21 dental students, 14 males and seven females, with a history of 2--10 years of headache, acupuncture was performed unilaterally in the foot between the 4th and 5th metatarsal bones (G 41). The needle was inserted to a depth of 10--15 mm and moved continuously by hand for 15--20 min. Electromyographic recordings of postural activity in the right and left anterior temporal and masseter muscles were obtained in the same sitting before, during and after acupuncture treatment. In clinical controls 24 h, 1 month and 4 months after the treatment, 12 subjects reported considerable improvement, two variable results, and seven no change. The electromyographic recordings showed an average decrease in postural activity during acupuncture, particularly of the temporalis muscles, and a further decrease after completed treatment. However, marked individual variations in muscular response were noted. The results indicate that acupuncture treatment can relieve headache, and that electromyographic recordings may provide objective evidence of the effect of acupuncture.
Inhibition of ectopic calcification of glutaraldehyde crosslinked collagen and collagenous tissues by a covalently bound diphosphonate (APD). (1990)

Calcification of collagen-derived prosthesis, such as glutaraldehyde crosslinked porcine heart valves or heart valves assembled out of bovine pericardium, presents a major clinical problem. Their subcutaneous implantation into young rats provides us with a reproducible method of assessing this form of ectopic calcification. Long-term implantation is essential, since some materials which do not calcify within the first month frequently exhibit a delayed calcific response. Crosslinked pericardium is much more likely to calcify than crosslinked tendon or reconstituted crosslinked pepsin extracted bovine type I collagen. The covalent binding of a diphosphonate to collagen and collagen-rich tissues can prevent calcification. The binding of this diphosphonate and its ability to inhibit calcification can be enhanced by increasing the number of amino groups on the collagen molecule. The degree of calcification is inversely related to the number of diphosphonate molecules covalently bound to collagen. Under standard conditions, chemical modifications appear to occur primarily on the surface of the collagen fibrils, as evidenced by the relationship between the number of molecules of APD bound and fibril diameter. The bound diphosphonate seems to interfere with crystal growth and prevent the formation of highly insoluble hydroxyapatite on the surface and interstices of the collagen fibrils.
A zinc finger protein from Candida albicans is involved in sucrose utilization (1992)

A sucrose-inducible alpha-glucosidase activity that hydrolyzes sucrose in Candida albicans has been demonstrated previously. The enzyme is assayable in whole cells and was inhibited by both sucrose and maltose. A C. albicans gene (CASUC1) that affects sucrose utilization and alpha-glucosidase activity was cloned by expression in a Saccharomyces cerevisiae suc2 mutant (2102) devoid of invertase genes. CASUC1 enabled the S. cerevisiae mutant to utilize both sucrose and maltose. DNA sequence analysis revealed that CASUC1 encodes a putative zinc finger-containing protein with 28% identity to a maltose-regulatory gene (MAL63) of S. cerevisiae. The gene products of CASUC1 and MAL63 are approximately the same size (501 and 470 amino acids, respectively), and each contains a single zinc finger located at the N terminus. The zinc fingers of CASUC1 and MAL63 comprise six conserved cysteines (C6 zinc finger) and are of the general form Cys-Xaa2-Cys-Xaa6-Cys-Xaavariable-Cys-Xaa2-Cys-+ ++Xaa6-Cys (where Xaan indicates a stretch of the indicated number of any amino acids). Both contain five amino acids in the variable region. CASUC1 also complemented the maltose utilization defect of an S. cerevisiae mutant (TCY-137) containing a defined mutation in a maltose-regulatory gene. The sucrose utilization defect of type II Candida stellatoidea, a sucrase-negative mutant of C. albicans, was corrected by CASUC1. Determinations of alpha-glucosidase activity in whole cells revealed that activity was restored in transformants cultivated on either sucrose or maltose. To our knowledge, this is the first zinc finger-encoding gene, as well as the first putative regulatory gene, to be identified in C. albicans.
[A prospective study of programmed nursing consultation in an urban health center]. (1991)

A study of the programmed nurse clinic in a health center was carried out to evaluate its different health care activities, the time consumed in them, the type of patients cared for, and the mechanism of organization of the clinic. A remarkable finding was a high number of daily appointments (11.8 persons), with an excellent rate of compliance with the appointment (89.3%). It was found that most of the diseases cared for in the nurse clinic were those most commonly managed with a protocol design in primary care: hypertension (34.1%), diabetes (6.9%), hyperlipoproteinemia (9%) and obesity (12.8%). Other parameters were evaluated, such as mean time per visit, which was predominantly between five and ten minutes, or activities during the visits, with a clear predominance of the clinical protocols. There was a remarkably high efficiency of the nursing staff, with a low rate of referral to the medical clinic (6.9%). We conclude that nurse clinics play an important role in the health centers, as the only possible mechanism to guarantee the correct fulfillment of the different programs. This requires a definite constant physical space for a given minimal period of time of about 2 hours per day.
FE modelling of a boundary layer corrector for composites using the homogenization theory (1996)

Using finite element (FE) method corrects the microstress field resulting from the theory of homogenization in the region of composite in vicinity of the boundary. Obtains the corrected microstress field via an unsmearing procedure based on the known global solution and local peturbation. Analyses two examples: near a free boundary and next to a constrained border. FE models are constructed using both commercial FE code and the authors’ program for homogenization with some interfacing procedures. Shows qualitative results of computations and estimates influence on the microstress description of the local perturbation near the boundary.
Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents (2012)

Laxiflorin J, isolated from the leaves of Isodon eriocalyx var. laxiflora , showed significant inhibitory activity toward T‐24 cells. A series of laxiflorin J derivatives were synthesized and their in vitro activity was evaluated against BEL‐7402, A‐549, HT‐29, HL‐60, MOLT‐4 tumor cell lines, with IC 50 values ranging from 1.3 to 42.2 μg mL −1 .
A novel method of Post processing algorithms for image and VP8 video codec's (2013)

This paper proposes post processing algorithm by employing modified adaptive (method or technique) in loop deblocking filter for VP8 and Image codec's, mainly because blocking artifact is one of the most annoying artifact especially in video and image compression coding. The method proposed improves the quality of the reconstructed image and as well as video. In this paper, we have introduced deblocking algorithm, classified them into several categories and implemented on Image and Video codec's. On the other side the PSNR is widely used for checking the quality of the compressed image and video. However, PSNR sometimes does not reveal the quality perceived by human visual system. In this paper, we will introduce another measurement to estimate the blockiness in the compressed image and video. So that VP8 video codec and image codec is successfully implemented based on this method to achieve better visual quality of video data and also achieve good performance.
Effects of Surfactants on High Regularity of 3D Porous Nickel for Zn<sup>2+</sup> Adsorption Application (2014)

Three‐dimensional porous nickel (3D‐PN) film with large specific surface area ( A s ) and high porosity has been successfully prepared by hydrogen bubble dynamic template (HBDT) method. This work presents the effects of PEG 10000 and 1,4‐butynediol as new additive combination on surface morphology of the PN film. Meanwhile, the application of 3D‐PN in Zn 2+ adsorption was preliminarily investigated in the paper. The surface area is determined as large as 166.7 cm 2 /mg and the porosity is 0.762 when the concentration of PEG 10000 and 1,4‐butynediol was 0.3 g/100 mL and 0.1 g/100 mL, respectively. The adsorption capacity ( Q t and Q (%)) of PN for Zn 2+ is observed to be 9.145 mg/g and 0.691 for Zn(NO 3 ) 2 ·6H 2 O. The morphology and the microstructure, the product formation, the A s the concentration of the metal ions were characterized by scanning electron microscopy (SEM), X‐ray powder diffraction (XRD), electrochemical impedance spectroscopy (EIS), and atomic absorption spectrometry (AAS), respectively.
Memory Disambiguation Hardware: a Review (2008)

One of the main challenges of modern processor designs is the implementation of scalable and efficient mechanisms to detect memory access order violations as a result of out-of-order execution. Conventional structures performing this task are complex, inefficient and power-hungry. This fact has generated a large body of work on optimizing address-based memory disambiguation logic, namely the load-store queue. In this paper we review the most significant proposals in this research field, focusing on our own contributions.
TeraHertz operational reachback (THOR) a mobile free space optical network program (2005)

The DARPA teraHertz operational reachback (THOR) program developed and assessed a suite of technologies for application in a mobile ad-hoc free space optical communication system. The notional THOR system includes airborne and ground based full duplex active terminals and passive optical terminals that form the physical layer of a high speed ad hoc mobile optical network. THOR consists of airborne terminals networked to form a communications backbone transmitting and receiving data at 2.5Gbps as well as passive optical terminals connected as high speed edge devices with a data rate of 200Mbps. The operational objective is to enable high data rate communications between a combat theater command post and an edge terminal linked to the global information grid (GIG) located outside of theater. DARPA investments were made in compact electro-optic beam steering devices to decrease the size and weight of optical terminals, high-speed high sensitivity (-47dBm) detectors, and high power (50W) modulating laser sources. Passive optical terminal technology investments focused on highspeed modulating quantum well focal plane arrays for integration with wide field of view +/-15 degree cat's eye optical systems to enable high speed modulating retro reflectors. Networking technologies included protocol assessments and quality of service algorithms to maintain low latency data transfer over unreliable optical data channels while maintaining data rates in the 2.5Gbps range. Analysis and network simulation results demonstrated that with multiple redundant links an all-optical network could operate with atmospheric weather conditions consisting of 80% broken cloud cover.
What Determines Export Participation of Private Domestic Manufacturing SMEs in Vietnam? (2015)

This study provides for the new evidence of factors determining export participation of private manufacturingSMEs in Vietnam. Using a recent national survey in 2011 about private manufacturing SMEs, we find that whilemore years in business does not affect the probability of firm exporting, firm with smaller scale have a lowerlikelihood of exporting. The results also indicate that innovation has a positive effect on exporting probability offirms implying that encouragement of innovative activities play an important role in promoting exportingparticipation of private domestic SMEs.