gebhart/patrepeval huggingface dataset:
Thermo-optically controlled ring resonator on silicon (1996)

A temperature controlled integrated optical ring resonator processed on a silicon substrate is studied using integrated polysilicon heater and thermistor elements. The response speed of the optical 2π phase shift is evaluated as the surface temperature of the device is measured with the thermistor. The effect of an applied heat sink on the device operation is studied.
Safe treatment of head/neck AD with Tacrolimus ointment (2003)

background: Atopic dermatitis(AD) with head and neck involvement is common and therapeutically challenging.methods: Efficacy and safety data specific to treatment of head/neck regions with tacrolimus ointment (Protopic®) from three double‐blind, randomized, vehicle‐controlled studies are reported. A total of 631 adult and 352 pediatric patients with moderate to severe atopic dermatitis applied the vehicle, 0.03% or 0.1% tacrolimus ointment twice daily to affected areas for up to 12 weeks.results: Significant improvements from baseline to end of treatment for signs of atopic dermatitis (erythema, edema, excoriation, oozing, scaling, and lichenification) were noted for head/neck and non‐head/neck areas treated with either 0.03% or 0.1% tacrolimus ointment (p<0.001). Within each treatment group, the overall 12‐week adjusted incidence rate of application site adverse events was similar for both head/neck and non‐head/neck areas. The incidence of common adverse events such as pruritus, “skin burning”, erythema, infection, and skin tingling in head/neck areas was comparable to that observed in non‐head/neck areas within each treatment group. The overall prevalence of application site adverse events decreased rapidly during the first few days of treatment.conclusion: Tacrolimus ointment is a safe and effective treatment for atopic dermatitis on the head and neck.
Citadel (2012)

The emergence of smart phones with embedded sensors has led to an explosion in the number of transport related research projects that leverage the widespread uptake of mobile devices. However, the process of collecting and managing travel-based sensor data in the field on a large-scale is difficult and resource-intensive. The process of obtaining a suitable dataset also provides an unnecessary distraction to researchers who are consequently unable to focus on the primary goals of their research such as gaining a better understanding of personal travel behaviors. In this paper we propose our vision for Citadel, an open community resource platform for collecting, managing and sharing archived travel sensor data to support transport research projects.
CHANGES IN PROTEOGLYCAN AND SULFATED PROTEIN SYNTHESIS DURING MEGAKARYOCYTE MATURATION IN VIVO (1987)

We investigated changes in sulfated proteoglycan (PG) and sulfated protein synthesis during megakaryocyte (MK) maturation in vivo by characterizing the (35S)-labeled molecules in MKs and platelets (PLTs) obtained daily from 3 hr to 5 days after injection of guinea pigs with (35S)sulfate. Radioactivity in macromolecules was maximal in MKs 3 hr and in PLTs 3 days after the injection. The cells were solubilized in 8M urea/50mM Tris/0.2% Triton X-100/0.1M NaCl, and PGs and sulfoproteins were separated by DEAE-Sephacel chromatography. PGs (65% of cell 35s) were eluted as two fractions, one (PG-1, 87%) with 4M Gdn HC1 and another (PG-2, 13%) with 4M Gdn HCl/2% TX-100. The Kav of PLT PG-1 on Sepharose CL-6B shifted gradually from 0.18 to 0.10 from 1-5 days after (35S) injection, and the smaller and larger PG-1 species were resolved on SDS-PAGE by fluorography. The size of PG-1 molecules was a function of glycosaminoglycan (GAG) chain length. The appearance of the different size PG-1 molecules in PLTs was accounted for by their disappearance from MKs over the same time period. Thus the size of the PG-1 synthesized by MKs decreased with MK maturation. The (35S)-PG-2 appeared in PLTs only 2-3 days after (35S) injection, had Kav 0.07 on CL-6B, but had GAGs of the same average size as those of PG-1. The hydrophobic character of PG-2 suggests that it might be the membrane PG. PG-1 and PG-2 were separated by SDS-PAGE and identified by fluorography. The core proteins of PG-1 and PG-2 were obtained by chondroitinase digestion and identified by SDS-PAGE and fluorography. The GAGs of PG-1 and PG-2 were almost entirely chondroitin-6-sulfate. The average size of PG-1 was 200,000 and its GAGs about 45,000. The sulfated proteins (20-25% of total cell 35S) eluted in the wash-through of the DEAE-Sephacel column and with 0.23M NaCl. Their isoelectric points were 4.0-6.5. They eluted as a small peak near the V0 and a major broad peak from Kav 0.3-0.6 on CL-6B columns, and could be identified as at least 8 distinct bands on SDS-PAGE by fluorography. Digestion with NaOH/NaBH4, Pronase or papain released small (35S)-labeled fragments, and the (35S) appeared to be associated with oligosaccharides. The sulfoproteins appeared in PLTs primarily 2-4 days after (35S) injection, and different proteins were labeled at different time points.
Large scale comparison of adjuvant effects on immunogenicity and protection in a Herpes Simplex Virus type 1 vaccination model (1997)

Conference Article| May 01 1997 Large scale comparison of adjuvant effects on immunogenicity and protection in a Herpes Simplex Virus type 1 vaccination model JACK R. SIMMS; JACK R. SIMMS 1Dept. Medical Microbiology, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom. Fax (++)114 2739926 Search for other works by this author on: This Site PubMed Google Scholar ANDREW W. HEATH; ANDREW W. HEATH 1Dept. Medical Microbiology, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom. Fax (++)114 2739926 Search for other works by this author on: This Site PubMed Google Scholar VERNON J. RICHARDSON; VERNON J. RICHARDSON *Institute of Cancer Studies, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom. Fax (++)114 2739926 Search for other works by this author on: This Site PubMed Google Scholar ROY JENNINGS ROY JENNINGS 1Dept. Medical Microbiology, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom. Fax (++)114 2739926 Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1997) 25 (2): 272S. https://doi.org/10.1042/bst025272s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation JACK R. SIMMS, ANDREW W. HEATH, VERNON J. RICHARDSON, ROY JENNINGS; Large scale comparison of adjuvant effects on immunogenicity and protection in a Herpes Simplex Virus type 1 vaccination model. Biochem Soc Trans 1 May 1997; 25 (2): 272S. doi: https://doi.org/10.1042/bst025272s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
Determination of melagatran in rabbit plasma by high‐performance liquid chromatography with automated column switching (2003)

Melagatran is an active thrombin inhibitor showing oral and parenteral bioavailability for antithrombotic therapy. A simple and convenient liquid chromatographic method has been developed and applied to the analysis of melagatran in rabbit plasma. The clean-up and separation of the sample solutions were performed by automated on-line column switching HPLC. The method validation shows the suitability of the column switching liquid chromatographic system for the quantitation of melagatran in biological fluids.
Electrochemical Characterization of Galvanic Couples Under Saline Droplets in a Simulated Atmospheric Environment (2016)

This work investigates galvanic corrosion of titanium and martensitic stainless steel alloys coupled with UNS A92024 and UNS A97075 in a simulated atmospheric environment under electrolyte droplets. Alloys were evaluated electrochemically in bulk electrolytes of varied chemistries relevant to atmospheric electrolytes. Microelectrodes and micro-salt bridges were utilized to probe droplet chloride concentration under various humidity levels. Droplets were monitored during polarization scans to track electrochemical behavior and disentangle the events occurring during cathodic polarization in small drops with microelectrodes. Predicted galvanic corrosion rates from polarization scans for bulk and droplet electrolytes were compared.
Dephosphorization kinetics and reaction region in hot metal during lime injection with oxygen. (1985)

To improve dephosphorization of hot metal by the lime injection process, it is necessary to clarify the dissolution mechanism of blown-in CaO in hot metal, the mechanism o f dephosphorization reaction and the region where the reaction takes place. For this purpose, a single-crystal lime lump immersion test and a lime powder injection test were made. Lime lumps after immersion tests, reaction products adhered to Al2O3 tubes immersed into hot metal and collected slag samples by steel samples were analyzed by EPMA.In hot metal, CaO starts to dissolve due to penetration o f FetO and MntO. Then, the dephosphorization reaction initiates between {CaO-Fe (Mn)tO}l and phosphorus, and the latter is fixed as (CaO-SiO2 P2O5)s in the reaction layers. Dephosphorization takes place mainly in the vicinity of the oxygen blowing nozzle.The slagging rate of solid CaO decreases with increasing distance between the nozzle and the suspending position of CaO since carbon in hot metal consumes oxygen. The dephosphorization rate also decreases with increasing distance since FetO in {CaO-Fe (Mn)tO}l is reduced by carbon.It is concluded that the increases both in the slagging rate of solid lime and oxygen potential in the bath is necessary to enhance the dephosphorization rate and in this sense, the injection of iron oxide with oxygen is effective.
Single-frequency, single-knob tuning of a CW color center laser (1985)

We describe a simple way to achieve CW single-frequency laser operation with a grating as the sole tuning element. It is Shown, both experimentally and theoretically, that by proper choice of cavity parameters, the competing hole burning modes can be completely suppressed. Experiments to demonstrate the theoretical calculations were carried out in a CW color center laser using Tl <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> (1) centers. Linewidths of 0.01 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> were obtained and this figure can probably be much improved by proper cavity stabilization. The method can be readily extended to any compact gain medium.
Phenotypic characterization of <i>Aspergillus niger</i> and <i>Candida albicans</i> grown under simulated microgravity using a three‐dimensional clinostat (2012)

ABSTRACT The living and working environments of spacecraft become progressively contaminated by a number of microorganisms. A large number of microorganisms, including pathogenic microorganisms, some of which are fungi, have been found in the cabins of space stations. However, it is not known how the characteristics of microorganisms change in the space environment. To predict how a microgravity environment might affect fungi, and thus how their characteristics could change on board spacecraft, strains of the pathogenic fungi Aspergillus niger and Candida albicans were subjected to on‐ground tests in a simulated microgravity environment produced by a three‐dimensional (3D) clinostat. These fungi were incubated and cultured in a 3D clinostat in a simulated microgravity environment. No positive or negative differences in morphology, asexual reproductive capability, or susceptibility to antifungal agents were observed in cultures grown under simulated microgravity compared to those grown in normal earth gravity (1 G). These results strongly suggest that a microgravity environment, such as that on board spacecraft, allows growth of potentially pathogenic fungi that can contaminate the living environment for astronauts in spacecraft in the same way as they contaminate residential areas on earth. They also suggest that these organisms pose a similar risk of opportunistic infections or allergies in astronauts as they do in people with compromised immunity on the ground and that treatment of fungal infections in space could be the same as on earth.
Probing Gap Plasmons Down to Subnanometer Scales Using Collapsible Nanofingers (2017)

Gap plasmonic nanostructures are of great interest due to their ability to concentrate light into small volumes. Theoretical studies, considering quantum mechanical effects, have predicted the optimal spatial gap between adjacent nanoparticles to be in the subnanometer regime in order to achieve the strongest possible field enhancement. Here, we present a technology to fabricate gap plasmonic structures with subnanometer resolution, high reliability, and high throughput using collapsible nanofingers. This approach enables us to systematically investigate the effects of gap size and tunneling barrier height. The experimental results are consistent with previous findings as well as with a straightforward theoretical model that is presented here.
Differentiation of Salmon Poisoning Disease and Elokomin Fluke Fever: Fluorescent Antibody Studies with Rickettsia sennetsu (1973)

SUMMARY Two endoparasite-transmitted rickettsiae, Rickettsia sennetsu and Neorickettsia helminthoeca , and the Elokomin fluke fever ( eff ) agent were distinguished by direct fluorescent antibody technique. Common major antigens were not detected among these agents. The direct fluorescent antibody technique could be applied as a differential diagnostic method for the agents of the salmon poisoning disease ( spd ) complex.
Metastable ion characteristics. II. Variation of metastable ion abundances in mass spectra with vibrational degrees of freedom (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetastable ion characteristics. II. Variation of metastable ion abundances in mass spectra with vibrational degrees of freedomFred W. McLafferty and William T. PikeCite this: J. Am. Chem. Soc. 1967, 89, 23, 5951–5953Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/ja00999a037https://doi.org/10.1021/ja00999a037research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SCALE-UP EFFECT ON SIZE-SEGREGATION OF SUGAR DURING FLOW (1998)

The size-segregation pattern was determined for two nearly binary mixtures (particle size ratios 2:1 and 5.7:1)of equal mass (1:1) granulated sugar under funnel flow and mass flow conditions from two bin sizes (small and large).The binary mixtures were deposited in the bins using the sprinkle-fill method to have a homogeneous initial fill. For funnelflow conditions, a distinctly fines-predominant flow stream was observed during initial discharge and a coarsepredominantflow stream was observed during the remainder of the discharge. Mixtures from the mass flow bins tended toremain and fluctuate about the ideal mass ratio of one. The mass ratio is defined as the mass of fines divided by the massof coarse particles in the sample. Statistical analysis (0.05 level of significance) confirmed that an increase in segregationoccurs during funnel flow-type compared to mass flow-type. As bin size increased, segregation appeared to decrease forboth particle size ratios. The greatest segregation ratio of normalized fines to coarse ratio was observed for 5.7:1 particlesize ratio during funnel flow in the small bin where the range was 0.39. The least segregation was seen in the large bin for2:1 particle size ratio under mass flow conditions, where the range was 0.02.
High-Dose Weekly AmBisome Antifungal Prophylaxis in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation: A Pharmacokinetic Study (2006)

Disseminated fungal infection causes significant morbidity and mortality in children undergoing hematopoietic stem cell transplantation (HSCT). The widespread use of prophylactic oral triazoles has limitations of poor absorption, interindividual variability in metabolism, and hepatic toxicity. AmBisome (amphotericin B liposomal complex) has a better safety profile than the parent drug amphotericin B and produces higher plasma and tissue concentrations. We hypothesized that once-weekly high-dose AmBisome therapy could provide adequate fungal prophylaxis for immunocompromised children undergoing HSCT. We performed a pharmacokinetic pilot study to determine whether once-weekly high-dose AmBisome administration would result in effective concentrations throughout the dosing interval. A total of 14 children (median age, 3 years, 1 month; range, 4.5 months-9 years, 9 months) undergoing HSCT received once-weekly intravenous AmBisome prophylaxis (10 mg/kg as a 2-hour infusion). Blood samples for pharmacokinetic measurements were drawn around the first and the fourth weekly doses. The concentration of non-lipid-complexed amphotericin in plasma was determined by a validated bioassay. Pharmacokinetic parameters after single doses and during steady state were calculated using standard noncompartmental methods. AmBisome was well tolerated at this dose. Complete pharmacokinetic profiles for weeks 1 and 4 were obtained in 12 patients. The half-life calculated in this pediatric population was shorter on average than reported in adults (45 hours vs 152 hours). The volume of distribution correlated best with body weight (R(2) = .55), and clearance was best predicted by initial serum creatinine level (R(2) = .19). Mean (+/- standard deviation) individual plasma trough concentrations were 0.23 (0.13) mg/L after single doses and 0.47 (0.41) mg/L after multiple doses. Mean steady-state area under the curve was higher at week 4 than after a single dose (P < .05). Single-dose and steady-state pharmacokinetic profiles were similar in 8 patients, whereas in 4 patients the week 4 profile showed nonlinear elimination. However, plasma concentrations at 7 days (Cmin) were not significantly different after the first and fourth doses, suggesting no significant accumulation over the course of therapy. Our data show measurable amphotericin B plasma concentrations 7 days after high-dose infusion of AmBisome. This suggests that once-weekly dosing, as described in this study, may provide useful protection against fungal infections.
Inhibition of Leukotriene B<sub>4</sub>Formation in Rat Peritoneal Neutrophils by an Ethanolic Extract of the Gum Resin Exudate of<i>Boswellia serrata</i> (1991)

Suspensions of rat peritoneal polymorphonuclear leukocytes (PMNL) elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic acid (AA). We investigated the effect of ethanolic extracts of the gum resin exudate of Boswellia serrata. A concentration-dependent inhibition of LTB4 and 5-HETE production by different charges of exudate extracts were found. All products of the 5-lipoxygenase (5-LOx) from endogenous arachidonic acid (AA) in PMNL were reduced to the same extent by the extracts tested. The ethanolic extract of the gum resin also decreased 5-LOx mediated metabolisation of exogenously added AA to LTB4 and 5-HETE. Since steroidal-type anti-inflammatory drugs do not exert an immediate effect in the test system used, we conclude that the activity of the 5-LOx itself represents the side of inhibition by the gum resin extract. Therefore, an inhibition of 5-LOx catalysed mediator synthesis might be involved in the previously reported anti-inflammatory activity in vivo.
Robust Optimization of Large-Scale Systems: An Emerging New Technology. (1995)

Abstract : A generalized interior point algorithm for convex objective functions has been developed and applied to various large scale problems. (AN)
Auditory P50 in Schizophrenics on Clozapine: Improved Gating Parallels Clinical Improvement and Changes in Plasma 3-Methoxy-4-Hydroxyphenylglycol (1999)

Schizophrenic patients have decreased inhibition of the P50 auditory evoked potential response to the second of two paired click stimuli delivered 500 ms apart. This deficit in inhibitory gating does not change during treatment with typical neuroleptics. We recently reported that neuroleptic-resistant schizophrenics had enhanced P50 gating after 1 month of clozapine treatment, if they responded with decreased clinical symptoms. This study reports the outcome of more prolonged treatment. Ten treatment-refractory schizophrenic patients were studied at baseline, after 1 month on clozapine, and again after 15 +/- 6.1 (SD) months of clozapine treatment. Eight subjects reached a clinically stable improved state, at which time they had significantly improved P50 auditory gating. One patient had a return of impaired gating after stopping clozapine, as did another during a clinical relapse. Decreasing plasma 3-methoxy-4-hydroxyphenylglycol levels with clozapine treatment were correlated with improved P50 gating and improved Brief Bsychiatric Rating Scale-positive scores. This study provides further evidence that improved P50 gating in schizophrenic patients treated with clozapine coincides with clinical improvement and that this improvement can be sustained for at least 1 year.
Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion (2013)

Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown to act as haploinsufficient tumor suppressors. How the deregulation of miRNA biogenesis promotes tumor development is not clearly understood. Here we show that loss of miRNA biogenesis increased resistance to endoplasmic reticulum (ER) stress-induced cell death. We observed that HCT116 cells with a DICER hypomorphic mutation (Exn5/Exn5) or where DICER or DROSHA were knocked down were resistant to ER stress-induced cell death. Extensive analysis revealed little difference in the unfolded protein response (UPR) of WT compared to Exn5/Exn5 HCT116 cells upon ER stress treatment. However, analysis of the intrinsic apoptotic pathway showed that resistance occurred upstream of the mitochondria. In particular, BAX activation and dissipation of mitochondrial membrane potential was attenuated, and there was altered expression of BCL-2 family proteins. These observations demonstrate a key role for miRNAs as critical modulators of the ER stress response. In our model, downregulation of miRNA biogenesis delays ER stress-induced apoptosis. This suggests that disrupted miRNA biogenesis may contribute to cancer progression by inhibiting ER stress-induced cell death.