gebhart/patrepeval huggingface dataset:
The influence of vincristine on the oestrogen-binding capacity of two human breast cancer cell lines <i>in vitro</i> (1986)

Conference Article| April 01 1986 The influence of vincristine on the oestrogen-binding capacity of two human breast cancer cell lines in vitro ROBERT CLARKE; ROBERT CLARKE *Department of Biochemistry, The Queen's University of Belfast, Belfast BT9 7 BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar JANET MORWOOD; JANET MORWOOD *Department of Biochemistry, The Queen's University of Belfast, Belfast BT9 7 BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOHN NELSON; JOHN NELSON *Department of Biochemistry, The Queen's University of Belfast, Belfast BT9 7 BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar HENDRIK W. VAN DEN BERG; HENDRIK W. VAN DEN BERG †Department of Therapeutics and Pharmacology, The Queen's University of Belfast, Belfast BT9 7 BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar RICHARD F. MURPHY RICHARD F. MURPHY *Department of Biochemistry, The Queen's University of Belfast, Belfast BT9 7 BL, N. Ireland, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1986) 14 (2): 449–450. https://doi.org/10.1042/bst0140449 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation ROBERT CLARKE, JANET MORWOOD, JOHN NELSON, HENDRIK W. VAN DEN BERG, RICHARD F. MURPHY; The influence of vincristine on the oestrogen-binding capacity of two human breast cancer cell lines in vitro. Biochem Soc Trans 1 April 1986; 14 (2): 449–450. doi: https://doi.org/10.1042/bst0140449 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: ER, oestrogen receptor, VCR, vincristine, E2, oestrogen This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
A simplified optical correlator for radar-signal Processing (1969)

Radar-signal processing is an interesting application of optical correlators. A simplified optical correlator is described and experimental results are presented.
Insight into the Surface Properties of Wood Fiber-Polymer Composites (2021)

The surface properties of wood fiber (WF) filled polymer composites depend on the filler loading and are closely related to the distribution and orientation in the polymer matrix. In this study, wood fibers (WF) were incorporated into thermoplastic composites based on non-recycled polypropylene (PP) and recycled (R-PP) composites by melt compounding and injection moulding. ATR-FTIR (attenuated total reflection Fourier transform infrared spectroscopy) measurements clearly showed the propagation of WF functional groups at the surface layer of WF-PP/WF-R-PP composites preferentially with WF loading up to 30%. Optical microscopy and nanoindentation method confirmed the alignment of thinner skin layer of WF-PP/WF-R-PP composites with increasing WF addition. The thickness of the skin layer was mainly influenced by the WF loading. The effect of the addition of WF on modulus and hardness, at least at 30 and 40 wt.%, varies for PP and R-PP matrix. On the other hand, surface zeta potential measurements show increased hydrophilicity with increasing amounts of WF. Moreover, WF in PP/R-PP matrix is also responsible for the antioxidant properties of these composites as measured by DPPH (2,2'-diphenyl-1-picrylhydrazyl) assay.
Research Spotlight: Delivery of Therapeutic RNA Molecules to Cancer Cells By Bacteria (2011)

Delivery of RNA-based therapeutics, for example RNA interference (RNAi) effectors, to target cells is one of the major obstacles for the development of RNA-based therapies. Since it has been known for a long time that bacteria can mediate tumor shrinkage, it was obvious to use nonpathogenic bacteria to produce and deliver therapeutic RNA molecules into target cells to induce RNAi. During the last years, two bacteria-based concepts were developed for this strategy, transkingdom RNAi (tkRNAi) and bacteria-mediated RNAi (bmRNAi). The first concept, tkRNAi, delivers RNAi effectors into target cells by invasive bacteria, which themselves produce therapeutic shRNAs. The bmRNAi technology utilizes invasive bacteria conveying RNAi effector-encoding DNA constructs that will act as a matrix for transcription of these sequences in the target cell by the host cell's transcription machinery.
Synchronization of motor-unit firings in several human muscles (1993)

1. Synchronization of concurrently active motor-unit firings was studied in six human muscles performing isometric constant-force contractions at 30% of the maximal level. The myoelectric signal was detected with a quadrifilar needle electrode and was decomposed into its constituent motor-unit action-potential trains with the Precision Decomposition technique, whose accuracy has been proven previously. 2. Synchronization was considered as the tendency of two motor units to fire at fixed time intervals with respect to each other more often than would be expected if the motor units fired independently. A rigorous statistical technique was used to measure the presence of peaks in the cross-interval histogram of pairs of motor-unit action-potential trains. The location of the center of peak as well as their width and amplitude were measured. A synch index was developed to measure the percentage of firings that were synchronized. The percentage of concurrently active motor-unit pairs that contained synchronized firings was measured. 3. Synchronization of motor-unit firings was observed to occur in two modalities. The short-term modality was seen as a peak in the cross-interval histogram centered about zero-time delay (0.5 +/- 2.9 ms, mean +/- SD) and with an average width of 4.5 +/- 2.5 ms. The long-term modality was seen as a peak centered at latencies ranging from 8 to 76 ms. On the average, the peaks of the long-term synchronization were 36% lower but had approximately the same width as the peaks for the short-term synchronization. Short-term synchronization was seen in 60% of the motor-unit paris, whereas long-term synchronization was seen in 10% of the pairs. 4. Short-term synchronization occurred in bursts of consecutive firings, ranging in number from 1 to 10, with 91% of all synchronized firing occurring in groups of 1 or 2; and the bursts of discharges appeared at sporadic times during the contraction. 5. The amount of synchronization in motor-unit pairs was found to be low. In the six muscles that were tested, an average of 8.0% of all the firings were short-term synchronized, and an average of 1.0% were long-term synchronized. The synch index was statistically indistinguishable (P = 0.07-0.89) among the different muscles and among 9 of the 11 subjects tested. 6. Sixty percent of concurrently active motor-unit pairs displayed short-term synchronization, 10% of the pairs displayed long-term synchronization, and 8% displayed both modalities.(ABSTRACT TRUNCATED AT 400 WORDS)
The Economics of Urban Renewal (1961)

In light of two implications of urban renewal, it is not at all surprising that this phenomenon provides an excellent area for the application of welfare economics. These implications are: First, that the market mechanism has not functioned properly in urban property; and second, that positive action can improve the situation. The propositions of welfare economics provide some tools for judging public policy measures such as urban renewal. But since these propositions themselves are based upon ethical postulates, it seems desirable that we begin our discussion of urban renewal by stating explicitly what we consider the role of the economist to be in this situation. I
Characterization and expression of the hydrogenase-encoding gene from Clostridium acetobutylicum P262 (1995)

The hydrogenase enzyme of Clostridium acetobutylicum plays a pivotal role in controlling electron flow, and hence carbon flow, during the complex biphasic fermentation of carbohydrates to the neutral solvents acetone and butanol. We report here the cloning and molecular characterization of the hydrogenase-encoding gene (hydA) from C. acetobutylicum P262. This gene was isolated by colony hybridization, using the Clostridium pasteurianum hydrogenase-1 gene as a probe. The DNA sequence encoding the hydA gene from C. acetobutylicum was determined, and revealed an ORF (1722 bp) encoding a 574 amino-acid protein. This C. acetobutylicum hydrogenase protein product has 82% similarity and 67% identity with the C. pasteurianum hydrogenase-1 protein. Northern blot analysis of RNA isolated from C. acetobutylicum indicates that the C. acetobutylicum hydrogenase protein product is translated from a monocistronic operon. RNA was isolated from the different morphological and physiological stages of a batch C. acetobutylicum fermentation, and further Northern blot analyses revealed no differences in the expression of the gene during acidogenesis as opposed to solventogenesis. Primer extension experiments confirmed these results and identified the 5' start of the mRNA transcript. These results correlated well with the physiological need for this organism to dispose of excess reducing equivalents.
Novel Slab Lens Based on Artificial Graded Index Medium (2005)

In this paper we present a novel slab lens based on artificial graded index medium. The lens is realized by etching 1-D subwavelength gratings into a high index slab waveguide to achieve the desired effective index distribution. A graded index profile is achieved by gradually modifying the duty cycle of the grating along the horizontal axis, whereas the beam is confined in the vertical direction by the slab waveguide. The proposed device is very attractive for various applications, including mode matching, coupling, guiding, imaging, optical signal processing, while offering the intrinsic advantages of monolithic, on-chip integration. The device is analyzed analytically numerically.
[Antioxidant vitamins and disease--risk of a suboptimal supply]. (1994)

Reactive oxygen species (ROS) such as the superoxide (O2.-) and the hydroxyl radical (OH.) are aggressive chemical compounds that can induce tissue injury, e.g. by peroxidation of polyunsaturated fatty acids in cell membranes or directly by DNA damage. Many pathological conditions are in part caused by ROS. There are various biological defense systems directed towards radicals: specific enzymes, e.g. superoxide dismutase or glutathione peroxidase; nonessential antioxidants, e.g. the plasma proteins and uric acid; and the essential antioxidants, e.g. vitamin C, vitamin E and carotenoids. This review focuses on various clinical conditions where ROS are of major pathogenetic significance: ageing, cancer, stroke, hematologic disorders, adult respiratory distress syndrome (ARDS) and organ preservation in transplantation medicine. Moreover, the complementary system of the vitamins C and E in defense against ROS is shortly discussed and the need for further studies about the effects of antioxidant treatment, such as interventional studies, proposed. The chronic exposure of the organism to ROS is an important factor for tissue injury in the process of ageing. Lipofuscin is a typical product of lipid peroxidation and inversely correlates with longevity of an organism. The ingestion of higher doses of antioxidative vitamins was recently shown to be protective for the development of cataracts, a degenerative disorder of the eye. The impairment of the immune system in elderly people might be prevented by a higher intake of multivitamin supplements. Whether supplementation with antioxidative vitamins can extend the life span in humans, as was shown in experimental animals, remains unanswered.(ABSTRACT TRUNCATED AT 250 WORDS)
Development and characterization of dilutable self-microemulsifying premicroemulsion systems (SMEPMS) as templates for preparation of nanosized particulates (2013)

The utilization of self-microemulsifying premicroemulsion systems (SMEPMS) as templates for preparing poorly water-soluble compounds in the nanosized range represents a promising strategy. Fenofibrate was formulated with n-butyl L-lactate, Tween 80, and a number of cosurfactants (ethanol, 1-propanol, and PEG 600), diluted with the water phase (either water or saccharide solution) and then subjected to a freeze-drying (FD) process to obtain SMEPMS nanosized particulates. Results demonstrated that the particle size after resuspension of these FD SMEPMS nanosized particulates in water was too large, so the addition of saccharide solutions (lactose, mannitol, glucose, sucrose, and trehalose) as the solid carrier to prevent particles from aggregating seemed to be necessary and workable due to steric hindrance and repulsion. However, instability of these resuspended FD nanosized particulates after 30-90 minutes still occurred, and the addition of 0.5% sodium lauryl sulfate in the resuspending medium was able to retard the aggregation and maintain the particle size within the nano-range. Evaluation by scanning electron microscopy and X-ray powder diffraction also confirmed the results. It was concluded that using an SMEPMS formulation with PEG 600 as the cosurfactant, and in the presence of a suitable saccharide as an anticaking agent and FD process were able to produce fenofibrate nanoparticles.
Microfabricated Nanoelectrospray Emitter Tips based on a Microfluidic Capillary Slot (Chapter 5) (2009)

An impetus in the field of mass spectrometry (MS) analysis occurred in the early 1990s with the invention of two novel and 'soft' ionization methods, electrospray ionization (ESI) by John Fenn and matrix-assisted laser desorption ionization (MALDI) by Koichi Tanaka, who both shared the Nobel-prize in Chemistry in 2002. http://www.springer.com/chemistry/analytical/book/978-0-85404-129-9
Chemistry and Kinetics of Oil Shale Retorting (2010)

Oil shale pyrolysis chemistry and kinetics are reviewed, with an emphasis on oil shale from the Green River Formation and work done by Lawrence Livermore National Laboratory during the 1970s and 1980s. Particular attention is given to measuring chemical kinetics of reactions generating oil in various kinds of reactors and of the reactions destroying oil by secondary coking and cracking. In addition, the realtionship between the reaction kinetics and various industrial processes is explored, including a classification scheme based on heating method.
The Measurement of a Complete Set of Transport Properties for a Concentrated Solid Polymer Electrolyte Solution (1995)

Polymer electrolytes based on alkali metal salts in poly(ethylene oxide) are important for possible use in rechargeable batteries for both electric vehicle and consumer electronics applications. We measure a complete set of transport properties for one particular binary salt solution: sodium trifluoromethanesulfonate in poly(ethylene oxide), over a wide range of salt concentrations (0.1 to 2.6M) at a particular temperature (85°C). The transport properties measured include the conductivity, the salt diffusion coefficient, and the sodium ion transference number. The mean molar activity coefficient of the salt is also determined. The conductivity is measured using the standard ac impedance method. The salt diffusion coefficient is found by using the method of restricted diffusion. The conductivity and diffusion coefficients of are similar in magnitude to those of in poly(ethylene oxide). The transference number and thermodynamic factor are found by combining concentration cell data with the results of galvanostatic polarization experiments. This novel method of measuring the transference number is straightforward to perform experimentally and yet does not require that the solution be either dilute or ideal. A theoretical analysis of the experimental method based on concentrated‐solution theory is given. Our study verifies that the transference numbers derived from the experiments retain fundamental significance in applications involving both steady and transient processes and in systems coupling the polymer electrolyte with electrodes of all types (stoichiometries). The relevant transference numbers can be determined independently of any knowledge of speciation of the polymer electrolyte. The transference numbers found here for the sodium ion are much lower than those reported for the lithium ion, especially in the concentrated solutions. The transference number of the sodium ion is negative in the more concentrated solutions and levels off at its maximum value of 0.31 in the dilute concentration range. The transference number results are interpreted in terms of complexation of the sodium ion with the anionic species.
Design, synthesis and characterization of heme-conjugated two-β-helix peptides (2006)

Iron porphyrins perform diverse functions in nature as cofactors of hemeproteins. In order to elucidate the functions of hemeproteins, considerable effort has been devoted to the construction of de novo designed peptides and proteins conjugated with porphyrin molecules by chelation [l–3] or covalent linkage [4–6]. To develop a mini-hemeprotein that meets minimal requirements for the function and exclude the complex factors of natural counterparts, we have attempted to design and synthesize a variety of 2α-helix peptides (Figure 1) that bind Fe-mesoporphyrin (heme) through a ligation of His residues.
Surface Characterization (1997)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSurface CharacterizationG. E. McGuire, P. S. Weiss, J. G. Kushmerick, J. A. Johnson, Steve J. Simko, R. J. Nemanich, Nalin R. Parikh, and D. R. ChopraView Author Information Center for Microelectronics, MCNC, 3021 Cornwallis Road, P.O. Box 12889, Research Triangle Park, North Carolina 27709 Cite this: Anal. Chem. 1997, 69, 12, 231–250Publication Date (Web):June 15, 1997Publication History Published online15 June 1997Published inissue 1 June 1997https://doi.org/10.1021/a1970009hCopyright © 1997 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1023Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (280 KB) Get e-AlertsSUBJECTS:Adsorption,Extended X-ray absorption fine structure,Scanning tunneling microscopy,Thin films,X-ray photoelectron spectroscopy Get e-Alerts
The Essential Oil Composition and Chemotaxonomical Appraisal of South African Pelargoniums (Geraniaceae) (2006)

A plethora of information is available on the essential oil composition of commercially grown Pelargoniums namely P. capitatimi, P. graveolens and P. radens and their hybrids, while only a few chemical investigations have been carried out on the other aromatic Pelargonium species indigenous to South Africa. The hydrodistilled leaf oils of 13 South African Pelargonium species of the genus Pelargonium (family Geraniaceae) were analyzed by means of GC and GC/MS and a total of 315 compounds were identified. The oil data was chemotaxonomically informative confirming taxonomic relationships i.e. between P. graveolens and P. radens, P. papilionaceum and P. vitifolium and between P. panduriforme and P. quercifolium. The oil compositions of P. citronellum, P. papilionaceum and P. vitifolium were different with respect to those of the other analyzed species in this study. Geranic acid was the most abundant oil constituent (36.0%) in P. citronellum (provenance NBG), which was the only species in which neral (17.4%) and geranial (27.2%) were detected. Citronellic acid dominated in the oils of P. papilionaceum (provenance NBG) and P. vitifolium (provenance SBG), occurring in amounts of 96.2% and 74.7%, respectively. The major monoterpene identified in P. radens (provenance NBG) and in the samples of P. graveolens (provenances SBG and WSBG) was isomenthone (84.5%, 65.8% and 83.3%, respectively). The P. tomentosum oil samples produced an essential oil rich in menthone (36.1-41.1%) and isomenthone (49.3-56.6%). The latter monoterpenic ketone was responsible for the chemical affinity demonstrated among P. graveolens, P. radens and P. tomentosum. p-Cymene was the principle component (37.6-45.4%) in both samples of P. panduriforme. It was also the major compound (54.9%) in P. quercifolium (provenance WSBG) followed by lesser amounts of viridiflorol (13.0%) and spathulenol (5.9%). Pelargonium quercifolium (provenance SBG) and P. capitatum (provenance WSBG) were characterized by a high viridiflorol content (24.0-36.6%). Pelargonium glutinosum (provenance SBG) was closely associated with the latter species; its oil was typified by oxygenated sesquiterpenes namely caryophyllene oxide (6.3%), spathulenol (6.9%) and viridiflorol (8.9%). Citronellyl formate (31.1%), citronellol (9.9%) and furopelargone B (6.1%) were most abundant in P. capitatum (provenance Strand). Pelargonium hispidum oil (provenance SBG) was characterized by decanoic acid (47.0%) and 2-decenoic acid (31.3%). Pelargonium scahrum produced an oil rich in 14-hydroxy-β-caryophyllene (27.9%). Pelargonium scabrum was associated with P. betulinum (provenance NBG) which was characterized by the oxygenated sesquiterpene T-cadinol (18.9%).
Measurement of Particulate Flow in Discrete Structure Particle Heating Receivers (2015)

Conventional central receiver power tower plants typically use steam or molten salts as the heat collection medium. Recently, attention has returned to using solid particulates in a particle-heating receiver (PHR). In this project we are interested in discrete structure PHR that includes structures, such as an array of wire mesh protrusions in our current design, to increase the residence time of particles falling through the receiver. The meshes should be sized to accommodate the falling particles without exposing too much mesh to concentrated radiation, which might degrade collection efficiency and expose the mesh material to high temperature thermal degradation. The experiment described in this paper was implemented to measure the appropriate exposed length of such discrete porous structures for a PHR. Particulates are introduced to the model PHR from a perforated plate distributor. As detailed in the body of the paper, a laser and photosensor (responding in units of lux) are used at positions 546 mm and then 1111 mm downstream from the perforated plate to measure the transparency of the flow in a vertical plane across the receiver. The laser light forms a vertical sheet, and its intensity is measured by the photosensor on the opposite side of the receiver. By comparing the lux data with and without particles flowing, the transparency of the particulate curtain can be determined. Different mesh counts have been tested and compared, and plotted for comparison. This research is useful for designers to use when planning a PHR and will inform the proper length of wire meshes to use. This paper reports the results obtained so far including a standard error propagation analysis.