gebhart/patrepeval huggingface dataset:
Effect of Temperature on Excited-State Proton Tunneling in wt-Green Fluorescent Protein (2008)

Steady-state emission and time-correlated single-photon counting (TCSPC) are used to measure the temperature dependence of the proton-transfer rate of wt-GFP in H2O and D2O. As the temperature decreases, the proton-transfer rate from the protonated form slows down. At about 80 K, the rate is about 10-fold slower than the rate at room temperature. At lower temperatures of 70 K down to 13 K (the lowest temperature studied), the rate of proton transfer is almost temperature independent. We explain the temperature dependence of the proton-transfer rate by an intermolecular vibration assisted tunneling mechanism. We attribute the specific intermolecular vibration to the oscillation of two oxygen atoms: the chromophore's phenol ring and the nearby water molecule. The kinetic isotope effect is about 5 and is almost temperature independent.
Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity (2007)

The mammalian circadian system consists of a central oscillator in the suprachiasmatic nucleus of the hypothalamus, which coordinates peripheral clocks in organs throughout the body. Although circadian clocks control the rhythmic expression of a large number of genes involved in metabolism and other aspects of circadian physiology, the consequences of genetic disruption of circadian-controlled pathways remain poorly defined. Here we report that the targeted disruption of Nocturnin (Ccrn4l) in mice, a gene that encodes a circadian deadenylase, confers resistance to diet-induced obesity. Mice lacking Nocturnin remain lean on high-fat diets, with lower body weight and reduced visceral fat. However, unlike lean lipodystrophic mouse models, these mice do not have fatty livers and do not exhibit increased activity or reduced food intake. Gene expression data suggest that Nocturnin knockout mice have deficits in lipid metabolism or uptake, in addition to changes in glucose and insulin sensitivity. Our data support a pivotal role for Nocturnin downstream of the circadian clockwork in the posttranscriptional regulation of genes necessary for nutrient uptake, metabolism, and storage.
Deceleration of infalling plasma in the atmospheres of accreting neutron stars. I - Isothermal atmospheres (1987)

This paper studies the physics of energy deposition in the highly magnetized atmosphere of an accreting neutron star. Specifically, it models proton stopping in plasma slabs of constant density and temperature. The calculations include both Coulomb collisions with atmospheric electrons and collective forces due to the resonant excitation of the atmospheric electron plasma modes by the impinging protons. The atmospheric protons do not contribute significantly to the stopping through electromagnetic forces. Attention is focused on the deceleration of the protons in the accretion flow, because they carry the bulk of the kinetic energy in the flow.
Tethering, recycling and activation of the epithelial sodium–proton exchanger, NHE3 (2009)

NHE3 is a sodium-proton exchanger expressed predominantly in the apical membrane of renal and intestinal epithelia, where it plays a key role in salt and fluid absorption and pH homeostasis. It performs these functions through the exchange of luminal sodium for cytosolic protons. Acute regulation of NHE3 function is mediated by altering the total number of exchangers in the plasma membrane as well as their individual activity. Traffic between endomembrane and plasmalemmal pools of NHE3 dictates the density of exchangers available at the cell surface. The activity of the plasmalemmal pool, however, is not fixed and can be altered by the association with modifier proteins, by post-translational alterations (such as cAMP-mediated phosphorylation) and possibly also via interaction with specific plasmalemmal phospholipids. Interestingly, association with cytoskeletal components affects both levels of regulation, tethering NHE3 molecules at the surface and altering their intrinsic activity. This paper reviews the role of proteins and lipids in the modulation of NHE3 function.
The Force Exerted by the Halo Pin (1992)

Seven different halo systems were evaluated biomechanically to compare the force exerted by the halo pin in each system. In three different experiments torque values of 2, 4, 6, 7, and 8 in lb were applied to the halo pin, and the force at the skull end of the halo pin was measured using a load cell. In the first experiment, the threads on the halo pin were dry, in the second experiment saline was applied to the threads on the pin, and in the third experiment cadaveric bone from the skull was interposed between the pin and the load cell. The results showed that for a given value of applied torque to the pin, the force exerted by the pin end varied widely according to the halo system and whether or not the pin was "lubricated."
Neutral components in the leaves and seeds of Syzygium cumini (2009)

The Syzygium cumini has medicinal importance as an anti-inflammatory, antibacterial, antiulcergenic. The major components of the leaves and seeds have the acid, neutral and phenolic fractions. In this study, the neutral fraction components which form the bulk is  studied in detail and results were presented. The neutral components of the leaves and seeds have been studied by gas-chromatography. A total of 13 and 42 compounds were identified in the leaves and seeds respectively. The main compounds in the leaf extract were  heptacosane, nonacosane, octacosane,  tricontane, octadecane and in the seed extract, 4-(2-2-dimethyl-6-6-methylenecyclohexyl) butanol, decahydro-8a-ethyl-1,1,4a,6-tetramethylnaphalene, octadecane, 1-chlorooctadecane and tetratetracontane were identified. The major compound in the leaves was octadecane and in the seed 1-chlorooctadecane.

	 

	Key words: Syzygium cumini, octadecane, nonacosane.
Pulsed-Latch Aware Placement for Timing-Integrity Optimization (2011)

Utilizing pulsed-latches in circuit designs is one emerging solution to timing improvements. Pulsed-latches, driven by a brief clock signal generated from pulse generators, possess superior design parameters over flip-flops. If the pulse generator and pulsed-latches are not placed properly, however, pulse-width degradations at pulsed-latches and thus timing violations might occur. In this paper, we present a unified placement framework for pulsed-latches to maintain the timing integrity. Our new placer has the following distinguished features: 1) a multilevel analytical placement framework to effectively prevent the potential pulse-width distortion problem; 2) a physical-location aware pulse-generator insertion algorithm to identify each desired group of a pulse generator and latches; and 3) a new optimization gradient for global placement to consider the impact of load capacitance of generators. Experimental results show that our placement flow can effectively consider pulse-width integrity and thus achieve much smaller total/worst negative slacks with marginal wirelength overheads, compared to a leading commercial and an academic placement flows.
Complete Treatment of Distillery (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplete Treatment of DistilleryA. M. Buswell and M. LebosquetCite this: Ind. Eng. Chem. 1936, 28, 7, 795–797Publication Date (Print):July 1, 1936Publication History Published online1 May 2002Published inissue 1 July 1936https://pubs.acs.org/doi/10.1021/ie50319a011https://doi.org/10.1021/ie50319a011research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Self-generated diversity produces “insurance effects” in biofilm communities (2004)

Diversity generally protects communities from unstable environmental conditions. This principle, known as the "insurance hypothesis," has been tested in many different ecosystems. Here we show that the opportunistic pathogen Pseudomonas aeruginosa undergoes extensive genetic diversification during short-term growth in biofilm communities. The induced genetic changes are produced by a recA-dependent mechanism and affect multiple traits, including the behavior of the bacteria in biofilms. Some biofilm-derived variants exhibit an increased ability to disseminate, whereas others manifest accelerated biofilm formation. Furthermore, the presence of these functionally diverse bacteria increases the ability of biofilms to resist an environmental stress. These findings suggest that self-generated diversity in biofilms provides a form of biological insurance that can safeguard the community in the face of adverse conditions.
Designing a Grid Computing Environment Shell Engine. (2003)

We describe the design and features of our Grid Computing Environments Shell system, or GCEShell. We view computing Grids as providing essentially a globally scalable distributed operating system that exposes low level programming APIs. From these system-level commands we may build a higher level library of more user-friendly shell commands, which may in turn be programmed through scripts. The GCEShell consists of a shell engine that serves as a container environment for managing GCEShell commands, which are client implementations for remote Web Service/Open Grid Service Architecture services that resemble common UNIX shell operations.
Artificial Insemination With Fresh or Frozen Semen (1973)

A comparison of fertilizing capacity was made between fresh semen and semen stored in liquid nitrogen. A total of 107 attempts at conception were made in 74 women. Fresh semen produced 35 conceptions in 48 attempts; frozen semen resulted in 36 pregnancies in 59 attempts. The 36 women who failed to conceive were found to have a high incidence of polycystic ovarian disease. The 71 conceptions resulted in 59 live births, 36 boys and 23 girls, 11 early spontaneous abortions, and 1 tubal pregnancy.
Leveraging Typing Phenomena to Design One-Handed Wearable Keyboards (2005)

Design practice in the HCI tradition often focuses on developing requirements from a task-based model of behavior. Touch typing is a complex task involving the translation of language into psychomotor rhythms acting on a spatial topology. An accurate model with appropriate emphases is difficult to construct; however, we may not need to construct the model if we can directly leverage the patterns of language and the innate tendencies of the human typist. This paper describes a design approach that leverages the phenomena of typing to inform the design of one-handed keyboards for wearable use. A reconfigurable keyboard is constructed and used in conjunction with a phrase set representative of the English language in a user study. The study resulted in various keyboard topologies and information about one-handed keyboarding relevant to design.
Precipitation of Germanium from Coal Fly Ash Leachates (2024)

The valorization of a coal gasification fly ash was studied by leaching the fly ash using different aqueous solutions followed by the subsequent precipitation of the germanium solubilized from the ash. Experimental investigations were focused on the precipitation of a germanium2catechol (CAT) complex with cetyl trimethyl ammonium bromide (CTAB). The influences of pH and amounts of CTAB and CAT on the precipitation yield were investigated. To this aim, a central composite rotatable design and ANOVA Design Expert 7.0.3 Wiley software were employed for experimental design and analysis of the results. Thus, the independent and combined effects of pH, CAT/Ge and CTAB/Ge molar ratios were investigated and optimized using a quadratic mathematical model. The optimum values of these factors were found to be 10, 12, and 4, respectively (in this case, the germanium precipitation yield was 98.8% for water leachates). The precipitation of germanium as a complex compound with CAT and CTAB was found to be selective towards germanium and this element can be effectively separated from As, Mo, Sb, V, or Zn. Total organic carbon in solution was measured to estimate the amounts of CAT and CTAB precipitated with germanium and with the interferences present in aqueous leachates. In addition, thermogravimetric analyses have been performed on the germanium-complex solids as a result of which 600uC was determined as the minimum temperature to completely remove the organic content of the precipitate.
[Functional characteristics of the endocrine and immune systems in patients with visceral candidiasis]. (1989)

A study was made of pituitary, thyroid, parathyroid, endocrine pancreatic, adrenocortical and immune system functions in 56 patients afflicted with visceral candidiasis. The clinical and laboratory data obtained point to the presence in some patients with visceral candidiasis of parathyroid, thyroid, pancreatic and adrenocortical dysfunctions, attesting to their importance in the disease pathogenesis. The role of immune disorders, particularly that of the T component of the immunity system is found to be of paramount importance as well in the pathogenesis of candidiasis. Correction of endocrine disorders coupled with antimycotic therapy brought about a more rapid and steadier therapeutic effect.
Topical locality in the Web (2000)

Most web pages are linked to others with related content. This idea, combined with another that says that text in, and possibly around, HTML anchors describe the pages to which they point, is the foundation for a usable World-Wide Web. In this paper, we examine to what extent these ideas hold by empirically testing whether topical locality mirrors spatial locality of pages on the Web. In particular, we find that the likelihood of linked pages having similar textual content to be high; the similarity of sibling pages increases when the links from the parent are close together; titles, descriptions, and anchor text represent at least part of the target page; and that anchor text may be a useful discriminator among unseen child pages. These results show the foundations necessary for the success of many web systems, including search engines, focused crawlers, linkage analyzers, and intelligent web agents.
Girard derivatization for LC-MS/MS profiling of endogenous ecdysteroids in Drosophila (2013)

Ecdysteroids are potent developmental regulators that control molting, reproduction, and stress response in arthropods. In developing larvae, picogram quantities of individual ecdysteroids and their conjugated forms are present along with milligrams of structural and energy storage lipids. To enhance the specificity and sensitivity of ecdysteroid detection, we targeted the 6-ketone group, which is common to all ecdysteroids, with Girard reagents. Unlike other ketosteroids, during the reaction, Girard hydrazones of ecdysteroids eliminated the C14-hydroxyl group, creating an additional C14-C15 double bond. Dehydrated hydrazones of endogenous ecdysteroids were detected by LC-MS/MS in the multiple reaction monitoring (MRM) mode using two mass transitions: one relied upon neutral loss of a quaternary amine from the Girard T moiety; another complementary transition followed neutral loss of the hydrocarbon chain upon C20-C27 cleavage. We further demonstrated that a combination of Girard derivatization and LC-MS/MS enabled unequivocal detection of three major endogenous hormones at the picogram level in an extract from a single Drosophila pupa.
Abortion Practice After Routine Training: A Prospective Cohort Study (2018)

PURPOSE: To explore Ryan Program graduates; post-residency practice in abortion care. BACKGROUND: The Ryan Program supports residency programs to integrate abortion into training. In 2012 we commenced a prospective cohort study of graduated residents. METHODS: Residents complete web-based surveys after the family planning rotation and consent to participate in future studies. In 2016, we surveyed ob-gyns 2+ years after residency about their current practice. Post-rotation and post-residency surveys were matched and then de-identified. RESULTS: Sixty percent (394) who consented to participate responded. Nearly all graduates did abortions during residency (median of 31, including medical and procedural techniques). 86% fully participated in training, while 14% opted out for personal or religious reasons. 33% percent overall, and 40% of those who intended to, do abortions in current practice (median of 12 per month). An additional 36% do not do abortions but wish to, and 16% do not nor desire to provide abortion care. Physicians doing abortions are more likely to have fully participated (42% vs. 8%, P =.00) and did more abortions in training than those not doing abortions (median 32 vs. 16, P =.00). Those without an academic affiliation (n=134) are less likely to do abortions (23% vs. 45%, P =.00) and more likely to want to integrate abortion care (56% vs. 44%, P =.02). DISCUSSION: One-third of ob-gyns who trained in Ryan programs include abortion care in their practice. An additional third are unable to despite intending to at the time of their training. Further studies are needed to understand the barriers to integrating abortion care into practice.
New Sensors for Cultural Heritage Metric Survey: The ToF Cameras (2011)

ToF cameras are new instruments based on CCD/CMOS sensors which measure distances instead of radiometry. The resulting point clouds show the same properties (both in terms of accuracy and resolution) of the point clouds acquired by means of traditional LiDAR devices. ToF cameras are cheap instruments (less than 10.000 €) based on video real time distance measurements and can represent an interesting alternative to the more expensive LiDAR instruments. In addition, the limited weight and dimensions of ToF cameras allow a reduction of some practical problems such as transportation and on-site management. Most of the commercial ToF cameras use the phase-shift method to measure distances. Due to the use of only one wavelength, most of them have limited range of application (usually about 5 or 10 m). After a brief description of the main characteristics of these instruments, this paper explains and comments the results of the first experimental applications of ToF cameras in Cultural Heritage 3D metric survey. The possibility to acquire more than 30 frames/s and future developments of these devices in terms of use of more than one wavelength to overcome the ambiguity problem allow to foresee new interesting applications.
An improved CMOS ring oscillator PLL with less than 4ps RMS accumulated jitter (2004)

This paper describes a low jitter phase-locked-loop (PLL) with a 4/sup th/ order control path, and a dual control voltage ring oscillator. Near constant voltage controlled oscillator (VCO) gain over process variations, in addition to compensation for feedback ratio variation, allows improved control of the PLL bandwidth. The PLL exhibits improved noise immunity with a wide (5:1) VCO frequency range, without the need for band switching or calibration routines. This PLL is fabricated in a 0.18 /spl mu/m CMOS logic process and exhibits <4 ps rms accumulated jitter.
Correlation of CMM Data with Flexible Fixturing (2001)

<div class="htmlview paragraph">To correlate data collected at multiple sites when using flexible fixturing to position parts for a CMM (Coordinate Measurement Machine), there are additional factors to consider and coordinate than when using CMM Holding Fixtures.</div> <div class="htmlview paragraph">When measuring sheet metal with hard gages or using CMM holding fixtures at multiple sites, the following factors must be considered: <ol class="list nostyle"> <li class="list-item"> <span class="li-label">1)</span> <div class="htmlview paragraph">Datums must be coordinated</div></li> <li class="list-item"> <span class="li-label">2)</span> <div class="htmlview paragraph">Part orientation must be common with respect to gravity</div></li> <li class="list-item"> <span class="li-label">3)</span> <div class="htmlview paragraph">Clamp sequence must be the same</div></li> <li class="list-item"> <span class="li-label">4)</span> <div class="htmlview paragraph">Measurement points and approach angles must be identical</div></li></ol></div> <div class="htmlview paragraph">When measuring sheet metal with flexible fixturing, such as a DEA System 5 (Manufactured by DEA Brown &amp; Sharpe), at multiple sites, additional factors come into play: <ol class="list nostyle"> <li class="list-item"> <span class="li-label">5)</span> <div class="htmlview paragraph">The locations of the programmable sheet metal supports (commonly called bowling pins) must be alike and positioned at, or as close as possible to, the same datums</div></li> <li class="list-item"> <span class="li-label">6)</span> <div class="htmlview paragraph">Clamping devices generally are not necessary</div></li> <li class="list-item"> <span class="li-label">7)</span> <div class="htmlview paragraph">The alignment points must be alike</div></li> <li class="list-item"> <span class="li-label">8)</span> <div class="htmlview paragraph">The quantity of iterations and acceptance criteria used for best fit must be the same</div></li> <li class="list-item"> <span class="li-label">9)</span> <div class="htmlview paragraph">Alignment points must be output in the measurement report</div></li></ol></div> <div class="htmlview paragraph">This paper will describe and demonstrate the importance of all of these factors and focus on the ones, which are unique to flexible fixturing systems, such as the DEA System 5.</div>
Reactions of 4-acyl-1-alkoxyaryl-5-aryl-3-hydroxy-2,5-dihydro-1H-pyrrol-2-ones with nucleophilic reagents (2011)

4-Acetyl-1-alkoxyaryl-5-aryl-3-hydroxy-2,5-dihydro-1H-pyrrol-2-ones reacted with amines to give 1-alkoxyaryl-5-aryl-4-(1-R-aminoethylidene)pyrrolidine-2,3-diones. Reactions of amines with 4-benzoyl-substituted analogs involve nucleophilic attack on the C3 atom in the heteroring to produce the corresponding 3-R-amino-1-alkoxyaryl-5-aryl-4-benzoyl-2,5-dihydro-1H-pyrrol-2-ones. Reactions of the title compounds with hydrazine hydrate, regardless on the substituent on C4, afforded 4-aryl-3-methyl(phenyl)-5-[2(4)-methoxyphenyl]-4,6-dihydropyrrolo[3,4-c]pyrazol-6-ones.