gebhart/patrepeval huggingface dataset:
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival (2008)

Protein kinase C alpha (PKCalpha) has been implicated in tumor development with high levels of PKCalpha expression being associated with various malignancies including glioblastomas and tumors of the breast and prostate. To account for its upregulation in these cancers, studies have suggested that PKCalpha plays a role in promoting cell survival. Here we show by siRNA depletion in U87MG glioma cells that a critical threshold level of PKCalpha protein expression is essential for their growth in the presence of serum and for their survival following serum deprivation. Derivation of PKCalpha wt and KO mouse embryo fibroblast cell lines confirms a role for PKCalpha in protecting cells from apoptosis induced by serum deprivation. Notably, PKCalpha was found to mediate chemo-protection in these fibroblastic cell lines. In U87MG cells PKCalpha does not confer chemoprotection though this likely reflects growth arrest associated with its depletion. To determine the requirements for catalytic function, comparison was made between distinct classes of PKC inhibitors. In contrast to loss of PKCalpha protein, inhibition of PKC kinase activity in glioma cell lines does not significantly inhibit growth or survival. Conversely, inhibition with calphostin C, which targets the regulatory domain of PKC, potently inhibits proliferation and induces apoptosis. Evidence is presented that it is the fully phosphorylated, folded form of PKCalpha that confers this activity-independent behaviour. These results indicate an essential pro-proliferative and pro-survival role for PKCalpha in glioma but question the use of ATP competitive inhibitors as therapeutics, either alone, or in combination with chemotoxic agents.
Successful Treatment of Chronic Fatigue Syndrome With Duloxetine and Trijodthyronine-A Case Study (2008)

Rosenhagen, Marcus C MD; Schmidt, Ulrike MD; Ebinger, Martin MD, PhD; Nickel, Thomas MD; Uhr, Manfred MD, PhD Author Information
GROWTH OF QUASI ONE-DIMENSIONAL CONDUCTING BLUE THALLIUM BRONZE CRYSTAL BY THE ELECTROLYTIC REDUCTION METHOD (1990)

A simple and expedient method of electrolytic reduction is used to grown blue thallium bronze single crystals that exhibit CDW transport properties at low temperature. The size of the crystals obtained is about 4×2×1 mm 3 . Electron probe analysis shows that the composition of the crystal is Tl 0.31 MoO 3.3
Carbohydrates Oxidation by <i>Pseudomonas albosesamae</i> nov. sp. (1964)

Journal Article Carbohydrates Oxidation by Pseudomonas albosesamae nov. sp.: Part II. Chemical Structure of the Product on Glucose and Gluconate Oxidation Get access Yoshiharu Wakisaka Yoshiharu Wakisaka Shionogi Research Laboratory, Shionogi & Co., Ltd., Osaka Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 28, Issue 12, 1 December 1964, Pages 819–827, https://doi.org/10.1080/00021369.1964.10858315 Published: 01 December 1964 Article history Received: 25 April 1964 Published: 01 December 1964
Recombinant allergens for immunotherapy. Where do we stand? (2004)

Recombinant allergen-based diagnostic tests will improve the selection of patients for immunotherapy. The first immunotherapy trial with recombinant allergens provides information about mechanisms underlying immunotherapy and holds promise that new types of allergy vaccines based on recombinant allergens will become available soon.
Introduction to Statistics and Computer Programming (1977)

(1977). Introduction to Statistics and Computer Programming. Technometrics: Vol. 19, No. 3, pp. 341-342.
LogoMedia (1993)

Even for the programmer, computer software can be a mysterious black box. But what if the programmer were able to give the box a good shake and listen to things rattle inside? Are there tools like the doctor's stethoscope that can help programmers listen to the heartbeat of their software? These are the kinds of questions we decided to explore by building LogoMedia, a sound-enhanced programming environment. LogoMedia supports the ability to associate non-speech audio with program events while the code is being developed. These associations cause subsequent test runs of the program to generate and manipulate sounds which can aid in the comprehension and analysis of the program's behavior.
Platelet Protease Nexin‐2/Amyloid <i>β</i>‐Protein Precursor (1991)

The amyloid beta-protein and its parent protein, amyloid beta-protein precursor (APP), are major constituents of neuritic plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. We reported that the protease inhibitor protease nexin-2 (PN-2) is the secreted form of APP that contains the Kunitz protease inhibitor domain. Previous studies suggested that circulating forms of PN-2/APP exist. Recently, we reported that PN-2/APP is a platelet alpha granule protein and is secreted upon platelet activation. Subsequent studies revealed that platelets are the major circulating repository for PN-2/APP and may contribute to its deposition in Alzheimer's disease. Protease inhibition measurements demonstrated that PN-2/APP is a potent inhibitor of certain serine proteases, particularly intrinsic blood coagulation factor XIa. Together, these findings indicate that PN-2/APP regulates blood coagulation, and possibly other proteolytic events, at sites of vascular injury.
Searching for emission line and OB stars in Cl 1806-20 using a NIR narrow-band technique (2010)

Abstract We survey the environment of Cl 1806-20 using near-infrared narrow-band imaging to search for Brγ features indicative of evolved massive stars. Using this technique, we successfully detect previously identified massive stars in the cluster. We detect no new emission line stars, establishing a firm upper limit on the number of Wolf Rayets and Luminous Blue Variables; however, we do find several candidate OB supergiants, which likely represent the bulk of the heretofore undiscovered massive star population.
Alkene metatheses in transition metal coordination spheres: dimacrocyclizations that join trans positions of square-planar platinum complexes to give topologically novel diphosphine ligands (2004)

The alkene-containing phosphines PPh((CH2)(n)CH=CH2)2)2 are prepared from PPhH(2), n-BuLi, and the corresponding bromoalkenes (1:2:2), and combined with the platinum tetrahydrothiophene complex [Pt(mu-Cl)(C(6)F(5))(S(CH2CH2(-))2)]2 to give the square-planar adducts trans-(Cl)(C(6)F(5))Pt(PPh((CH2)(n)CH=CH2)2)2 (11, 93-73%; n=a, 2; b, 3; c, 4; d, 5; e, 6; f, 8). Ring-closing metatheses with Grubbs' catalyst (2) are studied. With, two isomers of trans-(Cl)(C6F5)[formula: see text](14)Ph)(15e) are isolated after hydrogenation. Both form via dimacrocyclization between the trans-phosphine ligands, but differ in the dispositions of the PPh rings (syn, 31%; anti, 7%). The alternative intraligand metathesis product trans-(Cl)(C6F5)[formula: see text](14)Ph)2 (16e) is independently prepared by (i) protecting 4e as a borane adduct, H(3)B.PPh((CH(2))(6)CH=CH2)2, (ii) cyclization with 2 and hydrogenation to give H(3)B[formula: see text] (14), (iii) deprotection and reaction with 12. The sample derived from 11e contains < or = 2% 16e; mass spectra suggest that the other products are dimers or oligomers. The structures of syn-15e, anti-15e and 16e are verified crystallographically, and the macrocycle conformations analyzed. As expected from the (CH(2))(n) segment length, 11a undergoes intraligand metathesis to give (Z,Z)-trans-(Cl)(C6F5)Pt[formula: see text]CH2)2)2 (86%), as confirmed by a crystal structure of the hydrogenation product. Although 11b does not yield tractable products, 11c gives syn-(E,E)-trans-(Cl)(C6F5[formula:see text](21%). This structure, and that of the hydrogenation product (syn-15c; 95%), are verified crystallographically. Analogous sequences with 11d,f give syn-15d (5 and 14% overall).
THE FUNCTION OF CYTIDINE DIPHOSPHATE DIGLYCERIDE IN THE ENZYMATIC SYNTHESIS OF INOSITOL MONOPHOSPHATIDE<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE FUNCTION OF CYTIDINE DIPHOSPHATE DIGLYCERIDE IN THE ENZYMATIC SYNTHESIS OF INOSITOL MONOPHOSPHATIDE1Henry Paulus and Eugene P. KennedyCite this: J. Am. Chem. Soc. 1959, 81, 16, 4436–4437Publication Date (Print):August 1, 1959Publication History Published online1 May 2002Published inissue 1 August 1959https://pubs.acs.org/doi/10.1021/ja01525a088https://doi.org/10.1021/ja01525a088research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DETERMINATION OF REPRODUCTIVE CYCLICITY AND PREGNANCY IN ASIAN ELEPHANTS (ELEPHAS MAXIMUS) BY RAPID RADIOIMMUNOASSAY OF SERUM PROGESTERONE (1994)

The stages of the reproductive cycle and pregnancy of 15 Asian elephants (Elephas maximus) at Busch Gardens in Tampa, Florida were determined by measuring serum progesterone concentrations using a commercial radioimmunoassay (RIA) kit with a sensitivity of 40 pg/ml of serum. Blood samples were collected and analyzed weekly for a 45-mo period. Serum progesterone concentrations ranged from nondetectable (<40 pg/ml) in nonpregnant elephants to 2,110 pg/ml in pregnant elephants. The highest concentration of progesterone during the estrous cycle was 1,490 pg/ml. The length of the estrous cycle ranged from 10 to 23 wk, with an average (?SEM) of 15.1 ? 0.3 wk for 103 estrous cycles. One elephant had a consistently longer estrous cycle length (18.6 wk). The duration of the nonluteal phase was 4.6 ? 0.2 wk, and the duration of the luteal phase was 10.5 ? 0.2 wk. The serum progesterone concentration during the estrous cycle was 214.0 ? 5.2 pg/ml. The individual elephant average cycle length was used to estimate the time of estrus and ovulation. During the nonluteal phase, elephant cows were placed with a bull for mating. Two weeks after estrus began (based on rising progesterone at the end of the nonluteal phase), the cow was separated from the bull. Ovulation was predicted to occur during the first week after estrus began. Serum progesterone analyses were continued weekly to determine pregnancy or the next estrus. Eight elephants became pregnant, with a serum progesterone concentration of 554.6 ? 16.4 pg/ml and a range of < 40-2,110 pg/ml. These results confirm that weekly measurement of serum pro gesterone by RIA can be used to characterize the luteal and nonluteal phases of the Asian elephant estrous cycle. Using this information, cows can be managed and placed with a bull at the appropriate time for breeding. Serum concentrations of progesterone also can be used to confirm pregnancy and to monitor and evaluate potential problems during pregnancy. The approximate date of parturition can then be predicted from average gestation length data, thus allowing staff to prepare facilities and be ready to assist with delivery.
Unilateral versus Bilateral Middle Cerebral Artery Detection of Right‐to‐Left Shunt by Power M‐Mode Transcranial Doppler (2009)

Unilateral detection of ET by power M-mode transcranial Doppler is equivalent to bilateral detection to assess RLS.
Factors influencing product distribution in photocatalytic decomposition of aqueous acetic acid on platinized titania (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFactors influencing product distribution in photocatalytic decomposition of aqueous acetic acid on platinized titaniaHiroshi Yoneyama, Yoshiyuki Takao, Hideo Tamura, and Allen J. BardCite this: J. Phys. Chem. 1983, 87, 8, 1417–1422Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/j100231a027https://doi.org/10.1021/j100231a027research-articleACS PublicationsRequest reuse permissionsArticle Views356Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Stabilization of copper nanoparticles in zeolite suspensions (2015)

International audience
Hochaufgelöste 7T MRT bei Patienten mit Rektumkarzinom: Erste Ergebnisse (2015)

Ziel dieser Studie war die Evaluation eines modifizierten, hochaufgelösten MRT-Protokolls zur Ultrahochfeldbildgebung bei 7T in Vergleich zu 1,5T bei Patienten mit Rektumkarzinom.
RELATIONSHIP OF THE FOLINIC ACID GROUP AND THE LEUCONOSTOC CITROVORUM FACTORS (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRELATIONSHIP OF THE FOLINIC ACID GROUP AND THE LEUCONOSTOC CITROVORUM FACTORSThomas J. Bardos, Thomas J. Bond, Jean. Humphreys, and William. ShiveCite this: J. Am. Chem. Soc. 1949, 71, 11, 3852Publication Date (Print):November 19, 1949Publication History Published online1 May 2002Published inissue 19 November 1949https://pubs.acs.org/doi/10.1021/ja01179a520https://doi.org/10.1021/ja01179a520research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Alkali Metal Recognition Induced Isomerization of Spiropyrans. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
One geophysicist’s perspective of the 20th OTC (1988)

The Offshore Technology Conference quietly celebrated its 20th anniversary during the first week in May. The exhibition, permanently affixed in Houston, featured more than 1200 companies displaying the last word in offshore equipment. In this geophysicist’s opinion, it seemed that this was the major attraction for most registrants. Although considerable effort went into organizing the technical sessions, most attendees seemed to treat this aspect of the conference as a mere adjunct to the main event. Certainly the low attendance at the geophysical sessions supports this perception (and, historically, geophysical sessions are well attended by OTC standards).
[Arthroscopic repair of rotator cuff tear with five different methods]. (2009)

Depending on the correct diagnoses, 5 different methods of rotator cuff repair are used according to the different changes of shoulders, the outcome is good in all cases.
RE: SUCCESSFUL LIVING RELATED KIDNEY TRANSPLANTATION DESPITE RENAL ANGIOMYOLIPOMA IN SITU (2000)

No AccessJournal of UrologyLETTERS TO THE EDITOR1 Mar 2000RE: SUCCESSFUL LIVING RELATED KIDNEY TRANSPLANTATION DESPITE RENAL ANGIOMYOLIPOMA IN SITU L. Fritsche, K. Budde, P. Rogalla, I. Türk, H.-H. Neumayer, and S.A. Loening L. FritscheL. Fritsche More articles by this author , K. BuddeK. Budde More articles by this author , P. RogallaP. Rogalla More articles by this author , I. TürkI. Türk More articles by this author , H.-H. NeumayerH.-H. Neumayer More articles by this author , and S.A. LoeningS.A. Loening More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67847-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "RE: SUCCESSFUL LIVING RELATED KIDNEY TRANSPLANTATION DESPITE RENAL ANGIOMYOLIPOMA IN SITU." The Journal of Urology, 163(3), p. 924 References 1 : Angiomyolipoma masquerading as malignancy in renal transplantation. Nephrol Dial Transplant1993; 8: 642. Google Scholar © 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 163Issue 3March 2000Page: 924 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.MetricsAuthor Information L. Fritsche More articles by this author K. Budde More articles by this author P. Rogalla More articles by this author I. Türk More articles by this author H.-H. Neumayer More articles by this author S.A. Loening More articles by this author Expand All Advertisement PDF downloadLoading ...
Subthalamic stimulation for Parkinson disease: determination of electrode location necessary for clinical efficacy (2005)

The findings in this study lead the authors to suggest that a DBS electrode placed anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the STN (based on stereotactic atlas coordinates) provides similar clinical efficacy. Future studies may be warranted to evaluate prospectively the degree to which MER modification of the anatomically and/or image-determined target improves clinical efficacy of DBS electrodes.
Thin Film Single Crystal Growth of a Nonlinear Optical Polymer (1990)

Abstract : Over the past decade macromolecules with an extended chain geometry and conjugated backbone electronic structure have been established as novel electronic and optical materials. This includes photo-, thermo-, solvato-, and electro-chromism, large electrical and photo-conductivities and unique linear and nonlinear optical properties among others. Polydiacetylenes, a class of a conjugated polymers are considered possible candidate material for all optical switching and logic applications. In the transparent regime they possess some of the largest third order nonlinear optical susceptibilities. In general, it is extremely difficult to grow bulk polymeric single crystals. Polydiacetylenes, however, can be grown to large size in single crystal form. Single crystals of polydiacetylene can be directly grown from monomer single crystals through solid-state polymerization by heat. (js)
Integral thin film capacitors: Fabrication and integration issues (2002)

Although integral passive components have been used for over ten years, only recently has there been significant impetus to integrate. This is being driven by the need for miniaturization, increased performance and potentially lower costs. Discrete passives traditionally used in electronic products for decoupling, by-passing and line termination are becoming the speed bottleneck due to their size and distance from the active circuits. This problem can be circumvented by moving some of the function to the integrated chip. The passive devices can also be integrated into the printed wire board or part of a multichip module. Important integration issues involve the use of barrier metal layers and patterning. Metal migration under the influence of thermal or electric fields may produce shorts and render the entire device ineffective. Further more improved wetting can lead to decreased defect density and improved electrical characteristics and yield. To produce both test structures and working assemblies the electrodes and dielectric layers need to be compatible with standard photopatterning methods. In this paper we present our work on the fabrication of capacitor arrays by top electrode patterning, development of a photoimageable polymer-ceramic nanocomposite and copper metallization issues controlling integration.
New Jersey’s Experience with Structural Health Monitoring Devices Installed During Construction (2010)

Structural Health Monitoring (SHM) of bridges during construction, as well as over its service life, has recently become more attractive to owners and consulting engineers. With the introduction of new materials and construction methods, various types of bridges are being instrumented with monitoring devices to determine their performance as well as their response to various loading conditions. Among many other objectives, this includes monitoring concrete deck cracking behavior, measuring time-dependent deformations such as camber and deflection, and validation of new design or construction provisions. This paper highlights various types of instrumentation techniques used to monitor and test bridges during construction in New Jersey. For each case study, various type sensors are installed on the structure for field-testing and long-term monitoring. These sensors consist of strain transducers, accelerometers, geophones, vibrating wire strain gages, settlement sensors, pressure cells, and weigh in motion (WIM) system. This paper also provides an overview how data from various sensors could be processed to provide the actual behavior of the structure at various stages. Results of research work to verify and validate LRFD AASHTO (2008) design provisions as well as analytical models are employed to enable New Jersey Department of Transportation (NJDOT) to successfully update their design provisions.
Vesicle to Micelle Transition:  Rheological Investigations (1996)

Rheological experiments were carried out on aqueous dispersions of cetyltrimethylammoniumhydroxynaphthalenecarboxylate (CTAHNC) as a function of temperature. The results indicate the formation of very long elongated wormlike micelles at temperatures higher than about 50 °C, conferring to the system a very high viscosity. This behavior is explained by the combined effect of a large end cap energy and a low ionization degree resulting from a strong binding of the weakly soluble counterions. At lower temperature the surfactant forms a much more fluid vesicle phase, which is observed by videomicroscopy. Experiments performed on mixtures of CTAHNC and of cetyltrimethylammonium bromide (CTAB) show also a vesicle to micelle transition for a ratio of CTAB/CTAHNC that decreases upon increasing the temperature. The rheological behavior of the micellar phase obtained by mixing CTAB and CTAHNC is similar to that obtained for other charged micellar solutions.