gebhart/patrepeval huggingface dataset:
DNA-Dependent ATPase Activity of Bacterial XPB Helicases (2009)

XPB, the largest subunit of the eukaryotic transcription factor TFIIH, is essential for both initiation of transcription by RNA polymerase II and nucleotide excision repair (NER). XPB belongs to the SF2 superfamily of monomeric helicases. XPB helicase is thought to have evolved in eukaryotes; however, a gene highly homologous to human XPB can be found in a number of bacteria. This report is the first biochemical characterization of XPB homologues from bacteria, specifically those from Mycobacterium tuberculosis and Kineococcus radiotolerans. Similarly to eukaryotic XPB, bacterial XPB are ATP-dependent 3' --> 5' DNA helicases. The ATPase activity of these XPB helicases is DNA-dependent, requiring a minimum of 4-nucleotide long single-stranded DNA (ssDNA). The maximum rates of ATP hydrolysis are about 10 and 50 molecules per minute by one XPB monomer on a 21-nucleotide ssDNA oligomer and on 5-kb long circular ssDNA, respectively. The ATP hydrolysis by the bacterial XPBs is coupled to their translocation along single-stranded DNA. The hydrolytic activity is strongly dependent on both the nature of a nucleotide triphosphate and that of a divalent metal. The inefficient ATP hydrolysis by bacterial XPB is consistent with nonprocessive functions of its eukaryotic homologue in locally remodeling DNA during transcription initiation and NER.
Antitumor compositions and compounds (1992)

Eur. Pat. Publ. 484 596, Appl. 90/202,936.2, 06/11/90
Use of a hydrocapillary dressing in the management of highly exuding ulcers: a comparative study (2005)

Both treatment protocols were safe and effective in treating highly exuding chronic venous leg ulcers. The test dressing performed as well as or better than the comparator dressings for all study parameters and more patients preferred the test dressing to their previous dressing compared with the comparator dressings.
Sustained blood pressure increase after an acute stressor: the effects of the 11 September 2001 attack on the New York City World Trade Center (2005)

The World Trade Center attacks produced a substantial and sustained increase in blood pressure that appears to be independent of seasonal effects, and which has important implications for morbidity and financial burden. The ubiquitous continuing reference to the events in the news reports may contribute to the sustained effects.
Low-energy surface phonons of decagonal and icosahedral quasicrystals by inelastic He-atom scattering (2003)

Low-energy surface phonons (Rayleigh mode) on quasicrystals were investigated by inelastic He-atom scattering. The tenfold surface of decagonal ${\mathrm{Al}}_{71.8}{\mathrm{Ni}}_{14.8}{\mathrm{Co}}_{13.4}$ and the fivefold surface of icosahedral ${\mathrm{Al}}_{70.5}{\mathrm{Pd}}_{21}{\mathrm{Mn}}_{8.5}$ are found to possess well-defined Rayleigh modes with isotropic sound velocities of about 3840 m/s and 3470 m/s, respectively. The observed sound velocities are in good agreement with calculations based on the respective bulk data. The experimental phonon dispersions exhibit quasi-Brillouin-zone centers located at strong Bragg peaks.
Size-Monodisperse Metal Nanoparticles via Hydrogen-Free Spray Pyrolysis (2002)

Size-monodisperse pure copper particles (see Figure for a TEM image) are formed from metal salt precursors in a spray pyrolysis process that uses ethanol as co-solvent, thus avoiding the addition of hydrogen or other reducing gases. In addition, the uniform-size particles could be “classified” using a droplet impactor plate, which eliminates larger droplets at the atomizer prior to entering the reactor furnace.
Reticular Synthesis of HKUST-like tbo-MOFs with Enhanced CH<sub>4</sub> Storage (2015)

Successful implementation of reticular chemistry using a judiciously designed rigid octatopic carboxylate organic linker allowed the construction of expanded HKUST-1-like tbo-MOF series with intrinsic strong CH4 adsorption sites. The Cu-analogue displayed a concomitant enhancement of the gravimetric and volumetric surface area with the highest reported CH4 uptake among the tbo family, comparable to the best performing metal organic frameworks (MOFs) for CH4 storage. The corresponding gravimetric (BET) and volumetric surface areas of 3971 m(2) g(-1) and 2363 m(2) cm(-3) represent an increase of 115% and 47%, respectively, in comparison to the corresponding values for the prototypical HKUST-1 (tbo-MOF-1), and are 42% and 20% higher than that of tbo-MOF-2. High-pressure methane adsorption isotherms revealed a high total gravimetric and volumetric CH4 uptakes, reaching 372 cm(3) (STP) g(-1) and 221 cm(3) (STP) cm(-3), respectively, at 85 bar and 298 K. The corresponding working capacities between 5 and 80 bar were found to be 294 cm(3) (STP) g(-1) and 175 cm(3) (STP) cm(-3) and are placed among the best performing MOFs for CH4 storage particularly at relatively low temperature. To gain insight on the mechanism accounting for the resultant enhanced CH4 storage capacity, molecular simulation study was performed and revealed the presence of very strong CH4 adsorption sites near the organic linker with similar adsorption energetics as the open metal sites. The present findings support the potential of tbo-MOFs based on the supermolecular building layer (SBL) approach as an ideal platform to further enhance the CH4 storage capacity via expansion and functionalization of the quadrangular pillars.
Optimal Power Allocation with Channel Inversion Regularization-Based Precoding for MIMO Broadcast Channels (2009)

Zero-forcing (ZF) precoding scheme can achieve the asymptotic sum capacity as dirty-paper coding (DPC) in multiple-input multiple-output broadcast (MIMO-BC) channel when the number of users, , approaches infinity. However, the gap between ZF and DPC is not negligible in a practical range of , that is, . The capacity loss is partly due to the excessive transmission power penalty incurred by ZF when the channel matrix of the selected user subset is poorly conditioned. To avoid this power penalty, we propose to use a variation of ZF, channel inversion regularization (CIR), as a precoding scheme in MIMO-BC channels. But, unlike the interference-free ZF, the problem of maximizing sum-rate capacity using CIR precoding becomes nonconvex, which cannot be solved by water-filling strategy. Thus, we propose an efficient algorithm based on gradient projection (GP) as the optimal power allocation strategy for selected users, and show that the proposed CIR precoding scheme can achieve asymptotically the optimum sum-rate of the DPC strategy. Moreover, simulation results show that the CIR precoding scheme with the proposed optimal power allocation scheme achieves better sum-rate performance than ZF for a wide range of .
Forward-Secure Signatures with Untrusted Update. (2006)

In most forward-secure signature constructions, a program that updates a user&apos;s private signing key must have full access to the private key. Unfortunately, these schemes are incompatible with several security architectures including Gnu Privacy Guard (GPG) and S/MIME, wherethe private key is encrypted under a user password as a &quot;second factor&quot; of security, in case the private key storage is corrupted, but the password is not. We introduce the concept of forward-secure signatures with untrusted update, where the key update can be performed on an encrypted version of the key. Forward secure signatures with untrusted update allow us to add forward security to signatures, while still keeping passwords as a second factor of security. We provide a construction that has performance characteristics comparable with the best existing forward-secure signatures. In addition, we describe how to modify the Bellare-Miner forward secure signature scheme to achieve untrusted update.
Molecular Basis of the Mechanism and Regulation of Receptor-GTP Binding Protein Interactions: A Thesis (1997)

The photon receptor, rhodopsin, and the GTP-binding regulatory protein, transducin, belong to a family of G protein-coupled receptors. The activation process through which guanine nucleotide exchange of the G protein is accomplished was investigated utilizing these components of the visual transduction system. Rhodopsin, modelled as an enzyme in 
its interaction with substrates, transducin and guanine nucleotides, was characterized to catalyze the G protein's activation by a double-displacement mechanism. Remarkable allosteric behavior was observed in these kinetic studies. Equilibrium binding studies were performed to investigate the molecular basis of the positive cooperative behavior between transducin and rhodopsin. These experiments show that the origins of the allosterism must arise from oligomeric assemblies between receptor and G protein. The determined Hill coefficient, n H = 2, suggests that at least two transducin molecules are involved, and the B max parameter a1so indicates that multimeric assemblies of rhodopsin may participate in the positive cooperative interactiions. Physical studies of transducin in solution were performed and do not indicate the existence of a dimeric structure, in contrast to the kinetic and binding experiments which analyze interactions at the membrane surface. Since the latter environment represents the native surroundings in vivo, aspects of the allosteric behavior must be considered for a complete understanding of the signal transduction mechanism. The reported findings are interpreted in the context of homologies between other G protein-coupled receptor systems in order to develop a model for the molecular basis of the mechanism and regulation of this mode of signal transduction.
Oxidation and reforming of light hydrocarbons over Rh/Al₂O₃ catalyst by using a stagnation-flow reactor (2012)

National Research Center of the Helmholtz Association Oxidation and reforming of light hydrocarbons over Rh/Al2 O3 catalyst by using a stagnation-flow reactor Canan Karakaya1, Lubow Maier2, Olaf Deutschmann1, 2 Nicholas E. McGuire3, Neal P. Sullivan3, Robert J. Kee3 1 Institute for Chemical Technology and Polymer Chemistry, Germany 2 Institute for Catalysis Research and Technologies, Germany 3 Engineering Division, Colorado School of Mines, Golden, USA
Multivariate statistical tools applied to the characterization of the proteomic profiles of two human lymphoma cell lines by two‐dimensional gel electrophoresis (2005)

Mantle cell lymphoma (MCL) cell lines have been difficult to generate, since only few have been described so far and even fewer have been thoroughly characterized. Among them, there is only one cell line, called GRANTA-519, which is well established and universally adopted for most lymphoma studies. We succeeded in establishing a new MCL cell line, called MAVER-1, from a leukemic MCL, and performed a thorough phenotypical, cytogenetical and molecular characterization of the cell line. In the present report, the phenotypic expression of GRANTA-519 and MAVER-1 cell lines has been compared and evaluated by a proteomic approach, exploiting 2-D map analysis. By univariate statistical analysis (Student's t-test, as commonly used in most commercial software packages), most of the protein spots were found to be identical between the two cell lines. Thirty spots were found to be unique for the GRANTA-519, whereas another 11 polypeptides appeared to be expressed only by the MAVER-1 cell line. A number of these spots could be identified by MS. These data were confirmed and expanded by multivariate statistical tools (principal component analysis and soft-independent model of class analogy) that allowed identification of a larger number of differently expressed spots. Multivariate statistical tools have the advantage of reducing the risk of false positives and of identifying spots that are significantly altered in terms of correlated expression rather than absolute expression values. It is thus suggested that, in future work in differential proteomic profiling, both univariate and multivariate statistical tools should be adopted.
The Structure of Trifluoromethyl Acetylene from the Microwave Spectrum and Electron Diffraction Pattern (1951)

Measurements, in the microwave region, of the J = 3→4 rotational transitions of trifluoromethyl acetylene and several of its isotopic modifications have been made, and the moments of inertia, IB (in a.m.u.-Å2), have been found for the ground vibrational state: for CF3CCH, 175.613, CF3C13CH, 177.024, CF3CC13H, 181.302, and for CF3CCD, 187.462. Three lines corresponding to J = 3→4 transitions of CF3CCH in the excited vibrational state v10 = 1, and two lines corresponding to v10 = 2 and v10 = 3, have also been measured and interpreted according to Nielson's theory of l-type doubling in symmetric tops. From Stark effect measurements at different electric field strengths the dipole moment of CF3CCH in the ground vibrational state has been found to be 2.36±0.04 Debye units. For the ground vibrational state the microwave data lead to the following bond distances: C–H, 1.056±0.005Å; C≡C, 1.201±0.002A. The C–C and C–F distances were calculated from the measured moments of inertia for several assumed values of the FCF angle. Electron diffraction experiments were also made, and the intensity curves calculated for the assumed microwave models were compared with the observed visual curve. From the combination of microwave and electron diffraction results the best agreement was obtained with the following set of parameters: ∠FCF, 107.5°±1°; C–C, 1.464±0.02A; C–F, 1.335±0.01A.
Dynamic Measurements of the Position, Orientation, and DNA Content of Individual Unlabeled Bacteriophages B (2016)

A complete understanding of the cellular pathways involved in viral infections will ultimately require a diverse arsenal of experimental techniques, including methods for tracking individual viruses and their interactions with the host. Here we demonstrate the use of holographic microscopy to track the position, orientation, and DNA content of unlabeled bacteriophages (phages) in solution near a planar, functionalized glass surface. We simultaneously track over 100 individual λ phages at a rate of 100 Hz across a 33 μm × 33 μm portion of the surface. The technique determines the in-plane motion of the phage to nanometer precision, and the height of the phage above the surface to 100 nm precision. Additionally, we track the DNA content of individual phages as they eject their genome following the addition of detergent-solubilized LamB receptor. The technique determines the fraction of DNA remaining in the phage to within 10% of the total 48.5 kilobase pairs. Analysis of the data reveals that under certain conditions, λ phages move along the surface with their heads down and intermittently stick to the surface by their tails, causing them to stand up. Furthermore, we find that in buffer containing high concentrations of both monovalent and divalent salts, λ phages eject their entire DNA in about 7 s. Taken together, these measurements highlight the potential of holographic microscopy to resolve the fast kinetics of the early stages of phage infection.
Long-Term Nitrogen Dioxide Exposure (1973)

Male Long Evans hooded rats were chronically exposed to an average 2.9 ppm (±0.71 SD) of nitrogen dioxide 24 hours each day, five days a week for nine months. The major effects of NO2 were a significant 12.7% increase in lung wet weight, a 13.0% decrease in lung compliance, and a significant reduction in surface-active properties of the lung wash. The NO2-exposed lungs also revealed a significant 8.7% decrease in lung lipid content and a marked decrease in percentage of total saturated phospholipid fatty acids. This reduction in saturation was due almost entirely to a decrease in the percentage of palmitic acid. The suggestion is made that alterations in lung lipid metabolism may be the underlying mechanism which leads to some of the pulmonary effects following long-term exposure to subacute levels of NO2.
Metal-organic Frameworks and Polymetallic Dendrimer Complexes: New Perspectives for Near-infrared Imaging Based on Lanthanides (2016)

International audience
Psychiatric assessment of mood instability: qualitative study of patient experience (2013)

Patients with mood instability seek explanation for their symptoms and difficulties, empathetic care and consistent support as much as cure. Clinicians may incorrectly assume what patients' attitudes towards diagnosis are, a mismatch which may hamper the development of a strong therapeutic relationship. Clear, patient-centred communication, which acknowledges the patient's experience, may result in greater patient engagement and satisfaction.
Absorption of Crab Nebula X-Rays (1972)

The X-ray spectrum of the Crab Nebula closely follows a power law, I = 9E-2 0 photons 1 for photon energies above 1.5 heV. From 0.2 to 1.5 keV, interstellar absorption strongly attenuates the source spectrum. The equivalent hydrogen density to the Crab is (0.55 + 0.10) , in disagreement with the 21-cm absorption value of 0.26 cm ' (a distance of 2 kpc is assumed). The additional X-ray absorption is not expected from the filaments in the Crab Nebula, but could be due to invisible diffuse matter in the nebula. An alternative explanation is possible if interstellar grains contain a significant amount of matter from supernovae. The X-ray spectrum allows us to place the following upper limits on the average volume densities of elements with X-ray absorption edges in the 0.5-1.5-keV range: oxygen <1.5 X 10- , neon <2.5 X 10- , silicon <3 X 10- , and magnesium <1.3 X 10- cm-3.
Simple Method to Remove Completely Ciliate Protozoa of Adult Ruminants (1968)

Dioctyl sodium sulfosuccinate (Aerosol OT) has been used in a remarkably short period to obtain rumen ciliate-free cows. Two 30-g doses of Aerosol OT given on consecutive days appeared to effectively eliminate all types of rumen ciliate protozoa without harming the health of the host animal. Measurement of the rumen metabolic parameters of gas production, carbon dioxide to methane ratio, pH value, volatile fatty acids, ammonia, and in vitro cellulose digestion, along with total amylolytic streptococci counts of the rumen contents, showed that conditions in rumens of defaunated animals are normal 4 days after such treatment. It appears that such animals may be used in ruminal studies that require defaunated animals.
Visual navigation of a vehicle along roads: the algorithm and experiments (2002)

This paper is concerned with preview lateral control of an automated vehicle with a machine vision system. The lateral control is found with road edges captured by the machine vision so as to drive a vehicle along a road. The road edges are expressed in the machine vision system as two series of sampled points, and the optimal path is designed with the series of the sampled points, which enables the vehicle to drive safely and comfortably. Experiments with an automated guided vehicle (AGV) have been conducted, where the control period is about 0.5 sec and the vehicle drives at 0.3 m/sec. The results show the feasibility of the algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The preparation and photolysis of 3-aryl-3H-diazirines (1975)

The preparation of a number of 3-aryl-3H-diazirines is reported. On irradiation, these materials undergo both photolytic fragmentation to the arylcarbene and photoisomerisation to the linear diazo-compound which is then itself photolysed. The existence of a second intermediate is also apparent from the spectral changes observed.
Specific Expression and Regulation of CHIF in Kidney and Colon (1997)

International audience
APPLICATION OF I'tODERN HIGH RATE ANAEROBIC TREATtENT PROCESSES FeR WASTEWATER TREATtENT. (1991)

1. INTRODOCTION An adequate protection of the environment is of vital importance for all living creatures. Considering the world-wide deterioration of the environment, it is of utmost importance to find consistent long-term solutions in the very near future. This applies for the prosperous industrialized as well as for developing countries. For an adequate environmental protection, it is necessary to develop and implement methods and measures which lead to a .axi.u. of recycling and a .ini.u. of con~tive use. In this way the e~isting big waste and wastewater disposal and treatment problems gradually will vanish, although obvious­ ly to some e~tent there will always remain difficult wastewaters, concentrated slurries, and solid wastes, which need adequate treatment in order to protect the environment. Most developing countries suffer from severe environmental prob­ lems, a shortage of energy and resources, and frequently also from sufficient food production as well. These countries urgently need simple and ine~pensive and integrated environmental protection systems, which combine wastewater treat.ent with recovery and reuse (WTRR-.ethods). Important criteria to be set for such appropriate environmental protection technologies and methodologies are summarized in Table 1. The objective for applying wastewater treatment systems is preventing pollution of the aquatic environment. Considering wastewater treatment methods, in addition to the criteria mentioned in Table 2, some addi­ tional more specific criteria can be identified. These have been listed in Table 2.
Completion of Experimental Breeder Reactor-II Sodium Processing at Argonne National Laboratory (2002)

The Experimental Breeder Reactor - II (EBR-II) at Argonne National Laboratory - West (ANL-W) was shutdown in September 1994 as mandated by the United States Department of Energy. Located in eastern Idaho, this sodium-cooled reactor had been in service since 1964, and was a test facility for fuels development, materials irradiation, system and control theory tests, and hardware development. The EBR-II termination activities began in October 1994, with the reactor being maintained in an industrially and radiologically safe condition for decommissioning. With the shutdown of EBR-II, its sodium coolant became a waste necessitating its reaction to a disposal form. A Sodium Process Facility (SPF), designed to convert sodium to 50 wt% sodium hydroxide, existed at the ANL-W site, but had never been operated. The SPF was upgraded to current standards and codes, and then modified in 1998 to convert the sodium to 70 wt% sodium hydroxide, a substance that solidifies at 65°C (150°F) and is acceptable for burial as low level radioactive waste in Idaho. In December 1998, the SPF began operations. Working with sodium and highly concentrated sodium hydroxide presented some unique operating and maintenance conditions. Several lessons were learned throughout the operating period. Processing of the 330 m3 (87,000 gallons) of EBR-II primary sodium, 50 m3 (13,000 gallons) of EBR-II secondary sodium, and 290 m3 (77,000 gallons) of Fermi-1 primary sodium was successfully completed in March 2001, ahead of schedule and within budget.
DESIGN OF BROADBAND CIRCULARLY POLARIZED SQUARE SLOT ANTENNA WITH A COMPACT SIZE (2011)

This paper proposes a newly designed compact coplanarwaveguide-fed wideband circularly polarized (CP) printed square slot antenna (PSSA), in the square slot of which are a halberd-shaped feeding signal line and a square ring patch. By placing a specially designed metal reflector behind the bidirectional CP PSSA, one can obtain unidirectional CP patterns with a associated 3-dB axial-ratio bandwidth (ARBW) almost the same as that of the bidirectional antenna. The bidirectional L-and S -band PSSAs designed on FR4 substrates have 3-dB ARBWs as large as 25.3% and 29.1%, respectively. For the L-band antennas, the unidirectional design yields a 3-dB ARBW of 25.7% and a gain of about 3 dB higher than that of the bidirectional counterpart. In all these 3-dB axialratio bands, impedance matching with VSWR 2 is also achieved. Most importantly, the design concepts, procedures, and rules for the proposed antenna are presented in detail.