gebhart/patrepeval huggingface dataset:
Candida gut commensalism and inflammatory disease (2020)

The mammalian intestine harbors a collection of microbes ranging from viruses, archaea, protozoa, helminths, bacteria to fungi. This trans-kingdom community, the microbiota, has been demonstrated to modulate host immunity in health and disease. While bacterial components in this community have been extensively studied in the last two decades, the impact and composition of the fungal community in the gut, the mycobiome, have been recently unraveled. Multiple inflammatory diseases have been shown to link to change of gut mycobiome composition, predominantly the abundance of Candida species in the feces. While Candida species as a major colonizer in immunocompetent human beings are mostly supposed not harmful, they can cause life-threatening systemic infection under immunocompromised situation. Here we review the recent advances about the impact of Candida gut colonization on host immunity and development of inflammatory diseases in the absence of infections. We also discuss potential gaps in understanding the role of Candida species in inflammatory disease and the future perspective.
Ability of ICU Health-Care Professionals to Identify Patient-Ventilator Asynchrony Using Waveform Analysis (2016)

HCPs who have specific training in mechanical ventilation increase their ability to identify asynchrony using waveform analysis. Neither experience nor profession proved to be a relevant factor to identify asynchrony correctly using waveform analysis.
Structure and reactivity in complexes of iridium and rhodium. Part I. Crystal and molecular structure of bis-[1,2-bis(diphenylphosphino)ethane]rhodium(<scp>I</scp>) perchlorate (1970)

Crystals of bis-[1,2-bis(diphenylphosphino)ethane]rhodium(I) perchlorate (monoclinic, space group P21/c, a= 16·264, b= 16·807, c= 21·020 Å, β= 125·29, Z= 4) contain square-planar co-ordinated rhodium with Rh–P 2·306 Å(mean of four) and P–Rh–P (intraligand) 82·7°(mean). The exact conformation adopted in the cation by the bidentate diphosphine ligand, Ph2P·CH2·CH2·PPh2, appears to be determined by non-bonded interactions between the phenyl substituents on the phosphorus atoms. Consideration of the conformations of chelating bidentate diphosphine ligands in this and other structures shows that such ligands are flexible; the feature dominating the structure of these five-membered chelate rings is the staggered conformation about the CH2–CH2 bond. The barriers to torsion about M–P and P–C bonds are apparently lower than about CH2–CH2 bonds.
Radiographic progression in rheumatoid arthritis. (2006)

Radiographic progression is an important outcome measure in clinical trials and observational studies with patients with rheuamtoid arthritis. In this article we describe several aspects of measuring radiographic progression. We introduce the scoring method, discuss scoring methodology and issues regarding reliability of scoring, describe the relation between disease activity, radiographic progression and physical function, and introduce the concept of repair, a novelty in the field of measuring structural changes in RA.
Phenylethyl Isothiocyanate Induces Apoptotic Signaling via Suppressing Phosphatase Activity against c-Jun N-terminal Kinase (2002)

Dietary isothiocyanates induce apoptosis in various cancer cell lines through a c-Jun N-terminal kinase (JNK)-dependent mechanism. We found that phenylethyl isothiocyanate (PEITC) was capable of inducing JNK activation and apoptosis in prostate cancer cell lines with distinct p53 statuses. PEITC induced JNK-mediated apoptotic signaling via a different pathway than that used by DNA-damaging agents, because genotoxicresistant LNCaP prostate cancer cells were equally sensitive to PEITC as parental LNCaP cells. PEITC did not induce significant MKK4 or MKK7 activation and did not activate JNK directly, suggesting that JNK and JNK upstream kinases are not primary targets of PEITC. The JNK dephosphorylation and inactivation rates were decreased in cells exposed to PEITC. Expression levels of M3/6, a JNK-specific phosphatase, were down-regulated by PEITC via a proteasome-dependent mechanism. Taken together, our data suggest that PEITC activates JNK through suppression of JNK dephosphorylation and that PEITC may be an alternative therapeutic agent for cancers that are resistant to genotoxic agents. This study also reveals that JNK phosphatases are potential targets for the development of novel cancer therapeutic agents.
A high performance circularly polarized feed array for satellite communication antennas (2003)

The authors present breadboard results of a C-band circularly polarized feed array which has developed as part of the proof of concept (POC) antenna for INTELSAT VII coverage requirements. The feed array consists of 12 cup-dipole radiating elements arranged in a triangular grid. Each element is fed with a 3-dB hybrid coupler (to general dual circular polarization) and a TEM-line beam-forming network. The feed array illuminates a solid offset reflector antenna with a projected circular aperture with a diameter of 82 in. and a focal length of 76 in. Measured results of the feed array demonstrate that an axial ratio of less than 0.3 dB has been achieved over a 10% bandwidth. It is also shown that the secondary patterns of the POC antenna are in good agreement with the computed contours.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Metabolism of taurine by synaptosomal preparations from insects (1986)

Conference Article| June 01 1986 Metabolism of taurine by synaptosomal preparations from insects PETER S. WHITTON; PETER S. WHITTON *Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar RUSSEL A. NICHOLSON; RUSSEL A. NICHOLSON †Wellcome Pesticides, Berkhamstead, Herts, HP4 2DY, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROBIN H. C. STRANG ROBIN H. C. STRANG *Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1986) 14 (3): 609–610. https://doi.org/10.1042/bst0140609 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation PETER S. WHITTON, RUSSEL A. NICHOLSON, ROBIN H. C. STRANG; Metabolism of taurine by synaptosomal preparations from insects. Biochem Soc Trans 1 June 1986; 14 (3): 609–610. doi: https://doi.org/10.1042/bst0140609 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: GABA, γ-aminobutyric acid This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
Novel Synthesis of 1-Substituted 4-Hydroxypyrazoles (1983)

Synthese des methyl-1 et phenyl-1 hydroxy-4 pyrazoles a partir des derives ethoxycarbonyl-4 correspondants par l'intermediaire d'un alcool tertiaire en 4, du derive isopropenyl-4 et d'un hydroperoxyde
Video-augmented environments (1996)

This thesis was digitised by the British Library from microfilm. You can acquire a single copy of this thesis for research purposes by clicking on the padlock icon on the thesis file. Please be aware that the text in the supplied thesis pdf file may not be as clear as text in a thesis that was born digital or digitised directly from paper due to the conversion in format. However, all of the theses in Apollo that were digitised from microfilm are readable and have been processed by optical character recognition (OCR) technology which means the reader can search and find text within the document. If you are the author of this thesis and would like to make your work openly available, please contact us: thesis@repository.cam.ac.uk
Current Developments in Optical Fiber Technology (2013)

This book is a compilation of works presenting recent advances and progress in optical fiber technology related to the next generation optical communication, system and network, sensor, laser, measurement, characterization and devices. It contains five sections including optical fiber communication systems and networks, plastic optical fibers technologies, fiber optic sensors, fiber lasers and fiber measurement techniques and fiber optic devices on silicon chip. Each chapter in this book is a contribution from a group of academicians and scientists from a prominent university or research center, involved in cutting edge research in the field of photonics. This compendium is an invaluable reference for researchers and practitioners working in academic institutions as well as industries.
Continuous Cybersecurity Management Through Blockchain Technology (2019)

Traditional management practices applied to the cybersecurity realm are causing significant delays to the product release cycle for major organizations and government agencies. These delays are often seen as a necessary part of the security landscape to ensure appropriate approvals, audits, and risks are addressed prior to fielding software. However, the exact opposite outcome has been observed; delayed releases decrease overall security and functionality. This paper presents an alternative approval and review process using blockchain technology that complements agile development and continuous delivery paradigms. An example implementation is provided to demonstrate the behavior of the proposed system under hypothetical auditing and threat assessment scenarios.
A (1987)

ABEL OU LA MORT D’ABEL Tragédie lyrique en trois actes (réduits en deux en 1823) de François-Benoît Hoffmann. Musique de Rodolphe Kreutzer. Création au Théâtre de l’Opéra (salle Montansier) le 23 mars 1810 Décors de Protain fils, exécutés par Moench et Boquet, sous la direction d’Ignazio Degotti. Costumes de François-Guillaume Ménageot. A. I : Site riant et pittoresque. A. II : Les enfers. A. III, t. 1 : Site aride et sauvage. A. III, t. 2 : Le songe des maux. A. III, t. 3 : Gloire. Pour ces ...
Lens epithelial cell regression on the posterior capsule with different intraocular lens materials (1998)

The presence of LECs on the posterior capsule was considerably lower with polyacrylic than PMMA or silicone IOLs and LEC regression occurred more frequently. The lower incidence of LECs and the higher rate of regression may explain why PCO formation appears to be reduced with polyacrylic lenses. This has important clinical implications for the prevention of PCO.
Autosomal dominant polycystic kidney disease in blacks (1994)

Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of ESRD, but its frequency in blacks has not been well delineated and its course and the effects of sickle hemoglobin in this disease in blacks have not been previously reported. The occurrence of ADPKD in blacks and whites was determined in two ESRD populations: all ESRD patients seen over a 16-yr period in one area of Southeast Tennessee and all ESRD patients in 15 hemodialysis units in Tennessee and Atlanta, GA. The frequency of sickle hemoglobin was determined and compared in a group of nonrelated blacks with ESRD with and without ADPKD. The age at onset of ESRD and factors that might affect ADPKD such as gender, hypertension, and hemoglobin type were examined. ADPKD was a less frequent cause of ESRD in blacks than whites (1.4 versus 6.8%). However, after adjusting for the population rate, the incidence rates in blacks and whites were similar (0.48 and 0.47 of 100,000). There was a higher incidence of sickle hemoglobin in nonrelated blacks with ADPKD versus other black ESRD patients (50 versus 7.5%; P < 0.005). Blacks had an earlier onset of ESRD than whites (43.2 versus 55.4 yr; P < 0.0001), as did blacks with sickle-cell trait versus blacks without (38.2 versus 48.1 yr; P < 0.003). In this population, hypertension and gender had no effect on the onset of ESRD. ADPKD accounted for a smaller percentage of blacks than whites with ESRD because of the high percentage of blacks with renal disease from other causes.(ABSTRACT TRUNCATED AT 250 WORDS)
Treatment of Contaminated Groundwaters with Granular Activated Carbon and Air Stripping (1985)

Over the past several years there have been Increasing reports of cases of contaminated groundwater.Many cases were caused by leaking from surface impoundments or landfills, or leakage from underground storage tanks.Treatment of groundwater use, discharge or recharge into the aquifer is becoming a major concern.Two widely used treatment techniques are adsorption with granular activated carbon and packed tower air stripping.Granular activated carbon is often applied when organic contaminants need to be removed to nondetectable levels, and should be a part of the process if nonvolatile contaminants are present.Air stripping is capable of 95-99 percent reduction of volatile contaminants and can be a cost effective treatment technology if nondetectable contaminant levels are not required and air pollution is not a factor.Should off-gas from an air stripper require treatment for removal of organic contaminants, granular activated carbon adsorption can be effectively applied as it was in the water phase.Selection of a groundwater treatment technology depends on factors such as contaminant type, end use of the water and air pollution concern, and each case requires consideration of these factors to arrive at the most cost effective solution.
Flow Measurement Handbook (2000)

Flow Measurement Handbook is an information-packed reference for engineers on flow measuring techniques and instruments. Striking a balance between laboratory ideal and the realities of field experience, this handy tool provides a wealth of practical advice on the design, operation, and performance of a broad range of flowmeters. The book begins with a brief review of fluid mechanics principles, how to select a flowmeter, and a variety of calibration methods. Each of the following chapters is devoted to a class of flowmeters and includes detailed information on design, applications, installation, calibration, operation, and advantages and disadvantages. Among the flowmeters discussed are orifice plate meters, venturi meters and standard nozzles, critical flow venturi nozzles, positive displacement flowmeters, turbine and related flowmeters, vortex shedding and fluidic flowmeters, electromagnetic flowmeters, ultrasonic flowmeters, and coriolis flowmeters. Also covered are mass flow measurements using multiple sensors, thermal flowmeters, angular momentum devices, probes, and modern control systems. Many chapters conclude with an appendix on the theory behind the techniques discussed.
The Use of Heuristic Programming in Management Science—A Survey of the Literature (1961)

Intelligent problem-solving, whether by man or by machine, implies selective rather than just rapid behavior. Humans achieve this selectivity through heuristics—principles that, on the average, contribute to reduction of search in problem-solving. Heuristic programming is the construction of computer problem-solving programs whose behavior is similarly organized. This paper surveys the present and potential use of heuristic programming in management science.
Muscle temperature, contractile speed, and motoneuron firing rates during human voluntary contractions (1992)

A study was made of motoneuron firing rates and mechanical contractile parameters during maximum voluntary contraction of human hand muscles. A comparison of muscles that had been fatigued after a 60-s maximum voluntary contraction (MVC) with muscles that were cooled by approximately 5 degrees C showed that the contractile properties, in particular the rates of contraction and relaxation, were similarly affected in both conditions. In contrast, the motoneuron firing rate was affected differently by the two treatments. In the case of the fatigued muscles the motoneuron firing rate was reduced by 36%, as was expected from previous studies, but in the case of the cooled muscles, there was no significant change in the motoneuron firing rate. We conclude that the reflex reduction in the motoneuron firing rate seen in the fatigued muscle is not triggered directly by a change in the mechanical properties of the muscle.
Antigen localization in lymphopenic states. II. Further studies on whole body x-irradiation. (1966)

The gross and microscopic distribution of (125)I polymerized flagellin from Salmonella adelaide was studied in adult rats at various times following 800 r whole body X-irradiation. Injections of radioactive antigen were made in both hind footpads, and the popliteal lymph nodes were excised for autoradiographic study 1 day later. This dose of irradiation caused a progressive decline in the ability of lymphoid follicles of popliteal nodes to capture and retain antigen. Irradiation had no detectable effect upon antigen uptake by whole lymph nodes or upon the number of grains overlying the phagocytic cells of the medullary sinuses of popliteal nodes. Various substances capable of restoring follicular antigen uptake in the irradiated rat were studied by means of injecting the test substance into one hind footpad 1 hour prior to the injection of antigen into both feet. The distribution of antigen in each popliteal node was compared, each animal thus acting as its own control. It was found that 0.01 ml of specific anti-flagellar immune serum, or 0.25 ml of normal adult rat serum significantly improved follicular antigen uptake when tested ten days after irradiation. Foetal calf serum, homologous lymphocytes, and the media from pooled concentrated lymphocyte cultures were without demonstrable effects when given by regional injection. Shielding of the popliteal nodes at the time of irradiation improved follicular antigen uptake, whereas shielding of the femoral bone marrow and appendix was ineffective. No agent found capable of improving follicular antigen capture in the irradiated rat significantly altered footpad retention of antigen, whole organ counts of the popliteal nodes, or antigen localization in the phagocytic cells of the lymph node medulla. The results favour the interpretation that the follicular antigen trapping mechanism is extremely sensitive to changes in levels of opsonins; that substances present in normal adult rat serum act as `follicular opsonins'; that these substances decline exponentially following irradiation; and that these substances are secreted by small lymphocytes or their progeny.
Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine (2000)

Occult hepatitis B virus (HBV) infection has been reported as cases in which HBV DNA was detected despite the absence of any HBV serological markers or in cases in which anti-HBc antibody was the sole marker. The aim of the present study was to determine, using the polymerase chain reaction (PCR), whether HBV infection occurs in hepatitis C and non-A-E hepatitis patients without serological evidence of hepatitis B infection in Sao Paulo State. Two different populations were analyzed: 1) non-A-E hepatitis patients, including 12 patients with acute and 50 patients with chronic hepatic disorders without serological evidence of infection with known hepatitis viruses; 2) 43 patients previously diagnosed as hepatitis C with positive results for anti-HCV and HCV RNA. Among hepatitis C patients, anti-HBc was detected in 18.6% of the subjects. Three different sets of primers were employed for HBV DNA detection by nested PCR, covering different HBV genes: C, S and X. HBV-DNA was not detected in any sample, whereas the positive controls did produce signals. The lack of HBV DNA detection with these pairs of primers could be due to a very low viral load or to the presence of mutations in their annealing sites. The latter is unlikely as these primers were screened against an extensive dataset of HBV sequences. The development of more sensitive methods, such as real time PCR, to detect circular covalent closed DNA is necessary in order to evaluate this question since previous studies have shown that cryptic hepatitis B might occur.
Representing 'Australian Land' (2010)

This article examines how Indigenous Australians' claims to their land are represented in the mainstream, non-Indigenous Australian media. In so doing, the article explores the common tropes available to non-Indigenous Australians in relation to Indigenous ownership of land, and in particular the native title system. It is argued that whilst initial land claims are discussed in detail within the media from a variety of perspectives, subsequent Indigenous land use agreements are most commonly reported upon in terms of business and economic concerns, with 'failed' agreements represented as impediments to 'development'. Thus, whilst the claims of Indigenous Australians to their land are sometimes reported positively by the media, this is only insofar as native title does not impede business development, which is frequently represented as the way in which land ultimately ought to be used. Thus non-Indigenous readers are left with an image of native title whereby initial land claims are considered not to be threatening, but only to the extent that subsequent use of the land still fits a white Australian image of 'development'.
A phishing analysis of web based systems (2011)

Phishing is form of identity theft that uses the social engineering techniques and sophisticated attack vectors to harvest financial information from unsuspecting consumers. It is a kind of attack in which phishers use spoofed emails and fraudulent web sites to trick people into giving up personal information. Victims perceive these emails as trusted, while in reality they are the work of phishers interested in identity theft. Web site phishing attacks usually start with an e-mail that arrives in the victim's mailbox pretending to be a legitimate and known entity. Usually, the mail claims some urgent steps to be taken by the user to avoid blocking of user account and direct him to a web page asking him to enter private information. But the web page is not legitimate and has no association with the organization it claims to be. Hence, the number of phishing fraud is continuing to grow, and the costs of the damages caused are increasing day by day. Therefore, there is the urgent need for anti-phishing solutions and recently have been identified, a number of solutions to mitigate phishing attacks have been proposed.
A methodology for evaluation of a hospital's vertical transportation needs (1979)

This paper presents a case study of an evaluation of a University Medical Center's vertical transportation needs. The Hospital's traffic characteristics are documented and then modeled using a GPSS computer simulation model. The effect of several possible improvements in the Hospital transportation system are predicted through use of the model and the most cost effective alternatives chosen for implementation.The use of the model and the study's approach is not limited to university medical centers, and can be applied to evaluation of the vertical transportation needs of any size hospital, existing or planned.