gebhart/patrepeval huggingface dataset:
Absence of hematopoiesis from transplanted olfactory bulb neural stem cells (2004)

Neural stem cells giving rise to neurons and glia cells have been isolated from the embryonic and adult central nervous system. The extent to which they are able to differentiate into cells of non-neural lineages, such as the hematopoietic lineage, is nonetheless unclear. We previously reported the isolation of stem cells from the mouse olfactory bulb neuroepithelium. In the present study, we analysed whether olfactory bulb stem cells (OBSC) can generate cells with hematopoietic features. Cells were prepared from the olfactory bulbs of transgenic mice expressing enhanced green fluorescent protein (EGFP). In culture, transgenic cells proliferated with the same kinetics as wild-type cells. Following mitogen removal, both cell types gave rise to similar numbers of neurons, astrocytes and oligodendrocytes, indicating that EGFP overexpression does not alter OBSC proliferation and differentiation patterns. When these cells were injected into the tail vein of irradiated mice, no hematopoietic cells derived from the OBSC could be recovered in their peripheral blood, spleen or bone marrow. By contrast, when OBSC were transplanted into the adult brain, EGFP-positive cells were found in the striatum and corpus callosum; differentiated cells expressed antigenic markers of neurons and astrocytes. These results suggest that embryonic olfactory bulb stem cells are not endowed with the potential to produce hematopoiesis.
Electrophilic aromatic chlorine cation (Cl+) addition and CO.bul.+ substitution in the gas phase (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrophilic aromatic chlorine cation (Cl+) addition and CO.bul.+ substitution in the gas phaseTapio Kotiaho, Brian J. Shay, R. Graham Cooks, and Marcos N. EberlinCite this: J. Am. Chem. Soc. 1993, 115, 3, 1004–1014Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ja00056a027https://doi.org/10.1021/ja00056a027research-articleACS PublicationsRequest reuse permissionsArticle Views372Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development and Validation of a Rex1-RFP Potency Activity Reporter Assay That Quantifies Stress-Forced Potency Loss in Mouse Embryonic Stem Cells (2015)

Assays for embryonic stem cells (ESCs) of the blastocyst are needed to quantify stress-induced decreases of potent subpopulations. High-throughput screens (HTSs) of stressed ESCs quantify embryonic stress, diminishing laboratory animal needs. Normal or stress-induced ESC differentiation is marked by Rex1 potency factor loss. Potency reporter ESC assays were developed, using low-stress techniques to create transgenic ESCs. Rex1 and Oct4 promoters drove RFP and green fluorescent protein (GFP) expression, respectively. Lentivirus infection and fluorescence-activated cell sorting selection of ESCs obviated the need for stressful electroporation and antibiotic selection, respectively. We showed using immunoblots, microscopic analysis, flow cytometry, and fluorescence microplate reader that the response to stress of potency-reporter ESCs is similar to parental ESCs assayed by biochemical means. Stress caused a dose-dependent decrease in bright Rex1-RFP(+) ESCs and increase in Rex1 dim ESCs. At highest stress, ∼ 20% of bright Rex1-RFP cells are lost coinciding with a 2.8-fold increase in Rex1-RFP dim cells that approach 20%. This conversion of bright to dim cells tested by flow cytometry is commensurate with about 60% loss in fluorescence measured by microplate reader. Dose-dependent stress-induced Rex1-RFP and endogenous Rex1 protein decreases are similar. The data show that Rex1 reporter ESCs accurately report stress in a microplate reader-based HTS. The increasing dim Rex1 subpopulation size is balanced by the decreasing total ESC number during culture at multiple sorbitol doses. This is consistent with previous observations that stress forces potency decrease and differentiation increase to compensate for stress-induced diminished stem cell population growth.
Omics applications for better beef production (2015)

Omics applications for better beef production. 2. Annual Food, Nutrition and Agriculture Genomics Congress and Co-located Digital PCR and Advances in qPCR
Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition (2015)

These findings suggest that dual inhibition of EGFr (cetuximab) and JAK-STAT-3 (JAK1i) leads to greater radiosensitization than with either cetuximab or JAK1i alone and suggests that this combination treatment may be clinically relevant even for tumors with a marked range of STAT-3 activity.
ChemInform Abstract: OXIDATION VON STEROIDEN 1. MITT. PHOTOSENSIBILISIERTE OXIDATION VON DELTA(5,10/9,11)‐OESTRADIENEN (1974)

Abstract Die durch Methylenblau (Meb) sensibilisierte Photolyse des Östradiens (I) in Gegenwart von O,(Singulett‐Zustand) führt zu dem Hydroperoxid (II).
The Load-Displacement Characteristics of Neonatal Rat Cranial Sutures (2000)

This study provides data regarding the basic mechanical behavior of neonatal cranial sutures in a mammalian system.
Leukocyte Sulfatidase for the Reliable Diagnosis of Metachromatic Leukodystrophy (1981)

A simple assay technique for the determination of sulfatidase activity in leukocytes has been developed for the reliable diagnosis of metachromatic leukodystrophy (MLD). Sulfatide is tritiated in sphingosine and fatty acid by reduction with [3H]sodium borohydride in alkali in the presence of palladium chloride. This labeled natural substrate for aryl sulfatase A (AsA) is hydrolyzed by normal human leukocytes in 25 mM-acetate buffer, pH 5.0, in the presence of 0.3% sodium taurodeoxycholate. The enzyme activity is greatly improved after dialysis, exhibiting better linearity with protein concentration. It is stimulated maximally by 5 mM-MnCl2 with an apparent Km of 0.17 mM for the substrate. Patients with MLD exhibited virtually no detectable sulfatidase activity although they had residual AsA activity that was measured with the synthetic substrate, p-nitrocatechol sulfate (NCS). Potential heterozygotes could be identified by the sulfatidase assay in instances where the NCS assay for AsA was inconclusive. Several individuals with levels of AsA activity characteristic of MLD, including a few healthy carriers and certain patients with unknown neurological diseases, were shown not to have MLD by the presence of measurable levels of sulfatidase in their leukocytes.
Cooperative effects in vitro on fibroblast and keratinocyte functions related to wound healing by transforming growth factor-beta and a low molecular weight fraction from hemolyzed blood. (1994)

Blood or its constituents, respectively, contain a.o. substances such as TGF-beta (transforming growth factor-beta), PDGF (platelet-derived growth factor) and other factors, which beneficially influence wound healing. Patients with perivascular disturbances and consequently with inadequate supply of the affected tissue cells often suffer from poor healing of dermal wounds. Here, various cellular functions in situations of poor supply and related to wound healing, such as proliferation, colony formation, and migration of fibroblasts, and of monolayer formation by keratinocytes were emulated in vitro by supplementing cultures with reduced amounts of serum. Computer-aided image analysis allowed to quantify the cellular reactions under normal and serum-deprived medium conditions and under the influence of a low molecular weight fraction manufactured by dialysis of hemolyzed calf blood (HD, Solcoseryl) and of TGF-beta. Both preparations are in use for the treatment of poorly healing wounds. While HD preferentially normalized the reduced viability of fibroblasts, the keratinocyte activity was enhanced by TGF-beta. Restoration of fibroblast and keratinocyte functions proved most effective when combining HD with TGF-beta.
Implementation of bioherbicides and seed treatment in organic farming (2005)

The paper gives an overview over the prospects and risks of the application of bioherbicides in Organic Farming and wants to support the general acceptance by the EEC Council Regulation on Organic Production of Agricultural Products. Another problem of current importance is the maintenance of seed health. Several methods of seed treatments and their practical use are described (hot water, hot air, microwave steam, radio-frequency, low energy electrons, micro-organisms and natural substances).
State reference design and saturated control of doubly-fed induction generators under voltage dips (2016)

In this paper, the stator/rotor currents control problem of doubly-fed induction generator under faulty line voltage is carried out. Common grid faults cause a steep decline in the line voltage profile, commonly denoted as voltage dip. This point is critical for such kind of machines, having their stator windings directly connected to the grid. In this respect, solid methodological nonlinear control theory arguments are exploited and applied to design a novel controller, whose main goal is to improve the system behaviour during voltage dips, endowing it with low voltage ride through capability, a fundamental feature required by modern Grid Codes. The proposed solution exploits both feedforward and feedback actions. The feedforward part relies on suitable reference trajectories for the system internal dynamics, which are designed to prevent large oscillations in the rotor currents and command voltages, excited by line perturbations. The feedback part uses state measurements and is designed according to Linear Matrix Inequalities (LMI) based saturated control techniques to further reduce oscillations, while explicitly accounting for the system constraints. Numerical simulations verify the benefits of the internal dynamics trajectory planning, and the saturated state feedback action, in crucially improving the Doubly-Fed Induction Machine response under severe grid faults.
<i>v</i>‐Triazolines, XXIV. Pyrazolecarbaldehydes from 5‐Amino‐4,5‐dihydro‐4‐methylene‐<i>v</i>‐triazoles and Sydnones (1985)

Abstract The sydnones 1a – c react with the 4,5‐dihydro‐ v ‐triazoles 2a – c by long refluxing at 110– 140°C affording via non‐isolable adducts with elimination of CO 2 and N 2 and rearrangement a mixture of 4,5‐dihydropyrazoles 3a – c , 3‐pyrazolecarbaldehyde anils 4a – d , and 3‐pyrazolecarbaldehydes 5a – c . Compounds 3 can be deaminated to give 4 which can be hydrolyzed to yield the 3‐pyrazolecarbaldehydes 5 .– The sydnones 6a, b react similarly with 2a to give a mixture of 4‐pyrazolecarbaldehyde anils 7a, b and 4‐pyrazolecarbaldehydes 8a, b . The structural assignments are based on spectroscopic and X‐ray diffraction data.
Propagation of Pressure Waves in a Mixture of Water and Stream (1961)

The velocity of sound in mixtures of water and steam has been computed from the slope of the lines of equal entropy over a wide range of ambient conditions up to the critical point. The sound velocity is lower in the mixture than in either constituent It changes discontinuously on transition to the single phase in wet steam with just a trace of liquid The velocity is about 10 per cent less than in dry steam. The velocity decreases monotonically with increasing water content. In boiling water the velocity is very low. The smallest value occurs at reduced pressure at the triple point (with no solid ice present); the velocity here is as low as 0.012 m/s Rankine-Hugoniot curves were calculated for the mixture. These show that a shock-like compression in very wet steam or boiling water will condense all the steam giving rise to a large change in volume with very little rise in pressure. The Hugoniot curve lies very close to a line of constant entropy in this case. For high quality steam the compression will raise the temperature of the vapor and evaporate the liquid phase. This occurs far from constant entropy conditions, indicating a strong loss mechanism. In boiling water the propagation was studied with pressure waves having an amplitude exceeding the minimum necessary to condense all the steam. The velocity decreases monotonically with decreasing driving pressure, approaching the small amplitude acoustic velocity when the driving pressure approaches the minimum necessary to condense all the steam. In a straight pipe of boiling water true shocks were not propagated. The rise time of the compression wave steadily increases as it passes through the medium. On finally reaching a region of no bubbles, high peak pressures are observed. These peaks were an order of magnitude greater than the original driving pressure. This amplitude is apparently due to the formation of a water hammer.
Malignant Non-Functioning Pheochromocytoma of the Organ of Zuckerkandl Masquerading as a Primary Carcinoma of the prostate with Metastases (1973)

No AccessJournal of Urology1 Jul 1973Malignant Non-Functioning Pheochromocytoma of the Organ of Zuckerkandl Masquerading as a Primary Carcinoma of the prostate with Metastases Meyer M. Melicow, Aurelio C. Uson, and Ralph J. Veenema Meyer M. MelicowMeyer M. Melicow More articles by this author , Aurelio C. UsonAurelio C. Uson More articles by this author , and Ralph J. VeenemaRalph J. Veenema More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)60126-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1973 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byFuselier H (2018) Paraganglioma of the Bladder: Report of a CaseJournal of Urology, VOL. 113, NO. 1, (42-44), Online publication date: 1-Jan-1975. Volume 110Issue 1July 1973Page: 97-103 Advertisement Copyright & Permissions© 1973 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Meyer M. Melicow More articles by this author Aurelio C. Uson More articles by this author Ralph J. Veenema More articles by this author Expand All Advertisement PDF downloadLoading ...
THE EFFECT OF CORTISONE ON THE THYROIDAL AND RENAL METABOLISM OF IODINE (1953)

A MONG the many physiological alterations which follow the administration of ACTH or cortisone, apparent changes in the thyroidal metabolism of iodine have received recent attention. Both in animals and in man, these agents have been found to reduce the thyroidal accumulation of a tracer dose of radioactive iodine. (Wolfson et al, 1950; Hill et al, 1950; Frederickson et al, 1952; Kuhl and Ziff, 1952; Money et al, 1950, 1951). Similar alterations have been noted in animals receiving stressor agents (Soffer et al, 1949; Paschkis et al, 1950; Money et al, 1950; Williams et al, 1951). Since the abnormalities in the thyroidal radioactive iodine accumulation resulting from the administration of cortisone can be at least partially reversed by the administration of pituitary thyrotropin (TSH), it has been suggested that the changes produced by cortisone are the result of a diminution in the secretion of TSH by the pituitary gland (Hill et al, 1950).
ChemInform Abstract: Stereoselective Synthesis and Biological Activity of cis‐Azetidinones as Cholesterol Absorption Inhibitors. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Surface flashover measurements in vacuill1 and N<sub>2</sub> gas (1981)

An interferometric technique has been used to measure insulator surface charging in vacuum and high pressure nitrogen gas. Insulator surface charging has been observed in both cases. These data support the theory that insulator surface failure is caused by surface charging and intergap field enhancement.
Selectivity in nucleoside alkylation and aralkylation in relation to chemical carcinogenesis (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelectivity in nucleoside alkylation and aralkylation in relation to chemical carcinogenesisR. C. Moschel, W. R. Hudgins, and A. DippleCite this: J. Org. Chem. 1979, 44, 19, 3324–3328Publication Date (Print):September 1, 1979Publication History Published online1 May 2002Published inissue 1 September 1979https://pubs.acs.org/doi/10.1021/jo01333a010https://doi.org/10.1021/jo01333a010research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the design of time-varying tracking systems for precise model-following (1986)

New results are given for the design of the tracking portions of time-varying discrete-time tracking systems. The feedback regulator part of the system is driven by the tracking error with gains that make it an observer (or in the full-order case, a Kalman filter) of a reference input signal model. Application of these methods is illustrated with a design example.
Multiply bonded dimetal fluoroalkoxides. 1. Pentafluorophenoxides of dimolybdenum and ditungsten (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiply bonded dimetal fluoroalkoxides. 1. Pentafluorophenoxides of dimolybdenum and ditungstenRonald G. Abbott, F. Albert Cotton, and Larry R. FalvelloCite this: Inorg. Chem. 1990, 29, 3, 514–521Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/ic00328a036https://doi.org/10.1021/ic00328a036research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Die Logik der chemischen Synthese: Vielstufige Synthesen komplexer „carbogener” Moleküle (Nobel‐Vortrag) (1991)

„Die chemische Synthese ist das Herzstück der Chemie ‐ der zentralen Wissenschaft ‐, und ihr Einfluß auf unser Leben und unsere Gesellschaft ist allgegenwärtig.”︁ Diese Meinung vertritt Elias James Corey in seinem Nobel‐Vortrag, in dem er Ursprung und Entwicklung seiner mit dem Nobel‐Preis für Chemie 1990 ausgezeichneten Beiträge darlegt. Sein Konzept der retrosynthetischen Analyse hat die Organische Chemie in Forschung und Lehre revolutioniert, sein Einsatz von Computern in der Syntheseplanung war früh wegweisend, die vielen von ihm stammenden Synthesemethoden sind für den Synthetiker von unschätzbarem Wert, und die Totalsynthesen aus seinem Laboratorium ‐ z. B. die von Gibberellinsäure und Ginkgolid B ‐ sind Meilensteine der atemberaubenden Entwicklung in der organischen Synthese der letzten dreißig Jahre. magnified image
<title>X-ray production with ultrabright laser pulses</title> (1994)

X-ray emission and laser absorption have been studied with pulses of 1.5 ps duration irradiating solid targets at intensities of 10<SUP>18</SUP> W/cm<SUP>2</SUP>. Absorption as a function of the incident laser flux and the irradiation angle in respect to the polarization reaches maximal values of 50% and is discussed in comparison to theoretical works published recently. This gives basic guidelines for efficient x-ray production which we have investigated in the hard (E<SUB>x</SUB> > 50 keV, Bremsstrahlung) and soft (E<SUB>x</SUB> < 1 keV, line emission of ions) spectral region. The feasibility of a short pulse and a plasma source with an extension of only some microns is proofed with an experiment using a spherically bent Mica crystal for collimation of the x-ray beam. The brightness and divergence of that x-ray beam being relevant for applications are given.
An Advanced Technology of Finishing of Topologically Modified Involute Pinion for Low-Noise/Noiseless Car Transmission (2005)

<div class="htmlview paragraph">The paper is targeting solution to the problem of noise reduction in transmission of car, and light truck. The importance of gear mesh misalignment to gear noise is well established. It is customary to modify the gear micro-geometry to accommodate misalignment and minimize transmission error. Various feasible kinds of modification of a pinion tooth surface are considered. Topological modification of pinion tooth surface, if a proper design is accomplished, yields up to two times reduction of transmission errors. Reduction of transmission error results in corresponding reduction of noise excitation by gear train. An advanced technology of finishing of topologically modified pinion tooth surface for low-noise/noiseless car transmission is developed. The technology is oriented on application of a shaving cutter grinder with lack of <i>CNC</i> articulation. Lack of <i>CNC</i> articulation results in line contact of the shaver tooth surface and of the pinion tooth surface. In this concern, application of shaving cutter grinders that are capable of maintaining point contact of the shaving cutter and of the topologically modified involute pinion sounds most promising. An appropriate algorithm and computer software that are ready to be put into practice are developed as well.</div>