gebhart/patrepeval huggingface dataset:
Non-Markownikoff Addition in Reactions of 3,6-Divinyl-2,5-diketopiperazine (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNon-Markownikoff Addition in Reactions of 3,6-Divinyl-2,5-diketopiperazineH. R. Snyder and M. E. ChiddixCite this: J. Am. Chem. Soc. 1944, 66, 6, 1002–1004Publication Date (Print):June 1, 1944Publication History Published online1 May 2002Published inissue 1 June 1944https://pubs.acs.org/doi/10.1021/ja01234a049https://doi.org/10.1021/ja01234a049research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Histologic, Immunohistochemical, and Polymerase Chain Reaction Studies of Bottlenose Dolphins from the 1987-1988 United States Atlantic Coast Epizootic (1997)

Tissues from 95 bottlenose dolphins (Tursiops truncatus) that died during the 1987-1988 US Atlantic coast epizootic and 11 bottlenose dolphins that died along the Atlantic coast prior to 1987 were examined histologically and immunohistochemically. Polymerase chain reaction (PCR) testing was performed on 36 of the epizootic and all of the pre-1987 cases. Epizootic cases had syncytia and rare intranuclear and intracytoplasmic inclusion bodies within lung, lymph node, and spleen. Lymphoid depletion was present in lymph node, spleen, and gut-associated lymphoid tissue of epizootic cases. Pre-1987 cases did not have these pulmonary and lymphoid lesions. A larger percentage of epizootic than pre-1987 cases had bacterial and/or fungal infections (primarily pneumonias), pulmonary and lymphoid tissue histiocytosis, mucocutaneous ulcers, and evidence of negative energy balance. Immunohistochemically, 49/95 (52%) epizootic dolphins were positive for morbilliviral antigen. Morbilliviral antigen was detected in lung, lymph node, spleen, thymus, skin, tongue, esophagus, liver, pancreas, gastrointestinal tract, urinary bladder, oviduct, and mammary gland by immunohistochemistry. PCR testing identified morbilliviral RNA in 35/36 (97%) epizootic cases tested. Neither morbilliviral antigen nor morbilliviral RNA were detected in pre-1987 cases. Histologic, immunohistochemical, and PCR results provide strong evidence that morbillivirus infection was the primary cause of the 1987-1988 bottlenose dolphin epizootic.
Mechanism and feasibility of colloidal particle removal by a microcarrier process (2001)

Pollutants associated with colloidal particles in stormwater runoff have received increasing attention. Removal of these toxic particles is of paramount importance in regulating the quality of stormwater effluents. With the promulgation of the USEPA's Enhanced Surface Water Treatment Rule, a means for the removal of these particles in an efficient and rapid manner in treatment facilities is needed. This paper reviews the mechanisms and feasibility of a high rate sedimentation process in enhancing the settling in the flocculation‐sedimentation approach. The advantages of microcarriers, namely, to enhance particle capture as well as rapid sedimentation, are presented. A series of microcarrier‐jar tests was carried out. The experimental results reveal that the microcarrier process is effective in dramatically reducing treatment time and, in turn, reducing the size of treatment facility needed in a standard coagulation/flocculation unit operation.
Pilzfarbstoffe, 61 Flavomentine und Spiromentine, neue Terphenylchinon‐Derivate aus <i>Paxillus atrotomentosus</i> und <i>P. panuoides</i> (Boletales) (1989)

Abstract Die Kremplinge Paxillus atrotomentosus und P. panuoides produzieren in geringen Mengen orangegelbe Flavomentine und violette Spiromentine. Bei den Flavomentinen 1–3 handelt es sich um Ester des Atromentins ( 6 ) mit (2 Z ,4 E )‐2,4‐Hexadiensäure oder (2 Z ,4 S ,5 S )‐4,5‐Epoxy‐2‐hexensäure, außerdem kommt als weitere Verbindung dieses Typs 3‐ O ‐Acetylatromentin ( 4 ) vor. Die Spiromentine 8, 11, 12 und 13 besitzen eine ungewöhnliche Spirostruktur, in der ein 4,5‐Dihydroxy‐1,2‐benzochinon mit einem Lacton acetalartig verknüpft ist. Die spektroskopisch abgeleiteten Strukturen der Farbstoffe konnten durch die Synthese von Modellverbindungen und die biomimetische Überführung von Flavomentin B ( 2 ) in die Spiromentine B ( 11 ) und C ( 12 ) gesichert werden.
Natural attenuation general data guide. Final report (1999)

This guide is a decision-making tool to help remedial project managers (RPMs) determine whether natural attenuation can be used as a remedial option at contaminant release sites. Data requirements and methodology to evaluate the potential for using natural attenuation are presented. For sites where the natural attenuation remedial option is implemented, tables of commonly measured parameters, general data collection rationale, and interpretation guidance are included. This format allows the RPM to recognize data gaps, interpret data, construct a conceptual site model, and develop a sampling and analysis plan for evaluation and monitoring purposes.
Ionization and absorption effects in high-order harmonic generation in gas-filled hollow fibers (2001)

The influence of absorption and ionization on high-order harmonic generation in a gas-filled hollow fiber is analyzed within the framework of slowly varying envelope approximation. Harmonic spectra and pressure dependencies are calculated for high-order harmonic generation in hollow fibers filled with different rare gases. Ionization of the gas filling the fiber gives rise to self-phase modulation of the pump pulse, changing the phase mismatch within the pump pulse and shifting the maxima in pressure dependencies of high-order harmonics.
Human Tissue Kallikrein Gene Delivery Attenuates Cardiac Glycogen Accumulation in Streptozotocin-Induced Diabetic Rats (2000)

P58 The tissue kallikrein-kinin system is locally present in the heart and is reduced under diabetic conditions. In the present study, we explored the effects of kallikrein gene delivery in the heart under diabetic conditions. Intravenous injection of streptozotocin (STZ) (60mg/kg) into 8-week-old male Sprague-Dawley rats produced hyperglycemia (460 ± 10 mg/dl, n=30). Three weeks after STZ treatment, adenovirus containing the human tissue kallikrein gene (Ad.CMV-cHK) or green fluorescence protein gene (Ad.CMV-GFP) under the control of CMV promoter/enhancer were injected via the tail vein into STZ-diabetic rats. Adenovirus-mediated kallikrein gene delivery caused a significant reduction of blood pressure as compared to control rats receiving control virus (170.8 ± 3.5 vs. 187.4 ± 4.2 mmHg, n=8, P
Acute Adverse Effects of Blunt Adventitial Stripping (1995)

The adventitia is routinely removed from small arteries before the anastomosis, but the microcirculatory response to this maneuver has not been documented. We have used a rat cremaster muscle flap model for intravital microscopy to compare at the microcirculatory level the effect of blunt (n = 18) and sharp (n = 18) adventitial removal with unmanipulated control arteries (n = 18). Blunt stripping resulted in transient but significant reductions in the red cell velocity (50%, p < 0.05) and capillary perfusion (91%, p < 0.05). Sharp dissection did not affect red cell velocity; however, capillary perfusion was transiently reduced by 25% (p < 0.05). In this study, sharp adventitial dissection was found to be a less harmful method of small arteries preparation for microvascular anastomosis.
A two-dimensional electrostatic model for degraded LDD-nMOSFETs including spatial and energy distribution of hot-carrier-induced interface traps (2001)

A two-dimensional electrostatic model for degraded short channel lightly doped drain (LDD)-nMOSFETs is presented. The model is based on a numerical solution of the Poisson equation using the five-point finite difference approximation. The model takes into account all device details including doping profiles and spatial and energy distribution of hot-carrier induced interface traps in the LDD region. Potential and charge distributions within the device in weak (subthreshold) and strong inversion regimes have been extensively studied. The validation of the model has been carried out through comparison between simulated I-V characteristics in the linear region and published experimental data. The results obtained have shown that the drain current is greatly affected by the energy distribution of interface traps, especially in the low gate voltage range (near-threshold and subthreshold).
Closeness of solutions and averaging for nonlinear systems on Riemannian manifolds (2013)

An averaging result for periodic dynamical systems evolving on Euclidean spaces is extended to those evolving on (differentiable) Riemannian manifolds. Using standard tools from differential geometry, a perturbation result for time-varying dynamical systems is developed that measures closeness of trajectories via a suitable metric on a finite time horizon. This perturbation result is then extended to bound excursions in the trajectories of periodic dynamical systems from those of their respective averages, on an infinite time horizon, yielding the specified averaging result. Some simple examples further illustrating this result are also presented.
Progress in automatic meeting transcription (1999)

In this paper we report recent developments on the meeting transcription task, a large vocabulary conversational speech recognition task. Previous experiments showed this is a very challenging task, with about 50% word error rate (WER) using existing recognizers. The difficulty mostly comes from highly disfluent/conversational nature of meetings, and lack of domain specific training data. For the first problem, our SWB(Switchboard) system — a conversational telephone speech recognizer — was used to recognize wide-band meeting data; for the latter, we leveraged the large amount of Broadcast News (BN) data to build a robust system. This paper will especially focus on two experiments in the BN system development: model combination and HMM topology/duration modeling. Model combination can be done at various stages of recognition: post-processing schemes such as ROVER can lead to significant improvements; to reduce computation we tried model combination at acoustic score level. We will also show the importance of temporal constraints in decoding, present some HMM topology/duration modeling experiments. Finally, the meeting browser system and meeting room setup will be reviewed.
Les alcaloides défensifs de fourmis du genre Solenopsis: configuration absolue et biosynthèse (1996)

Doctorat en Sciences
Guidelines for reporting of phase equilibrium measurements (IUPAC Recommendations 2012) (2012)

Recommendations are given for reporting in the primary scientific literature of measurements involving phase equilibrium. The focus is on documentation issues, and many of the recommendations may also be applied to the more general fields of thermodynamic and transport properties. The historical context of the work and specific plans for implementation of the recommendations are discussed.
Rod-like ruthenium(II) coordination polymers: synthesis and properties in solution (1999)

Well defined coordination polymers obtained via the conversion of 4,4″-bis(2,2′:6′,2″-terpyridine)-2′,5′-dihexyl-p-terphenyl and activated ruthenium(III) show intrinsic viscosities of up to [η] ≈ 300 mL g–1 and a tremendous polyelectrolyte effect in salt-free DMA solution proving both their high molecular weights and considerable chain stiffness.
L'utilisation des modèles en génie des procédés, les réseaux de neurones (1994)

Presentation of research projects on neural techniques in process engineering and in evaluation process of the quality of food products: wine caves, flower selection, quality of granular products in the air, complex decision making applied to vine quality, presentation of partners. / Présentation des travaux de recherche utilisant les techniques neuronales aussi bien dans le génie des procédés que dans le processus d'évaluation de la qualité des produits agro-alimentaires : cave vinicole, tri des fleurs, qualité des produits granulaires en vol, prise de décision complexe appliquée à la qualité de la vigne, présentation des partenaires.
Quantum model of strong and ultra-strong coupling with free space radiation (2016)

Strong and ultra-strong light-matter coupling are remarkable phenomena of quantum electrodynamics arising when a matter excitation interacts so strongly with the electromagnetic field that the two systems cannot be distinguished as in usual perturbation theory. This is generally achieved by coupling an excitation with large oscillator strength to the confined electromagnetic mode of an optical microcavity. In this work we report on a phenomenon of non-perturbative spontaneous emission taking place in the absence of optical confinement, when a collective electronic excitation superradiantly decays into free space radiation. By using a quantum model based on the input-output formalism, we calculate the linear optical properties of a dense electron gas displaying superradiant excitations. We show that the commonly used rotating-wave and Markov approximations yield unphysical results when the radiative broadening is comparable to the matter excitation energy, i.e. in the ultra-strong coupling regime. Our formalism also allows computing the electron gas thermal emission, showing that Kirchhoff's law applies in all the regimes of light-matter interaction.
Drop shape dynamics under shear-flow reversal (2000)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Stefano Guido, Mario Minale, Pier Luca Maffettone; Drop shape dynamics under shear-flow reversal. J. Rheol. 1 November 2000; 44 (6): 1385–1399. https://doi.org/10.1122/1.1315310 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
High-power and tunable operation of a diode-bar-pumped double-clad Tm-doped silica fibre laser at 2 μm (2002)

Summary form only. Double-clad fibre lasers offer a means for scaling to high power with the advantage that thermal loading is distributed over a long length of fibre minimising the risk of damage. The beam quality is determined by the waveguiding properties of the core, which can easily be tailored to produce a single-mode output. The fibre used in our experiments was fabricated in-house and had a Tm-doped aluminosilicate core.
Curcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NFκB-p300 Cross-talk in Favor of p53-p300 in Breast Cancer (2011)

Breast cancer cells often develop multiple mechanisms of drug resistance during tumor progression, which is the major reason for the failure of breast cancer therapy. High constitutive activation of NFκB has been found in different cancers, creating an environment conducive for chemotherapeutic resistance. Here we report that doxorubicin-induced SMAR1-dependent transcriptional repression and SMAR1-independent degradation of IkBα resulted in nuclear translocation of p65NFκB and its association with p300 histone acetylase and subsequent transcription of Bcl-2 to impart protective response in drug-resistant cells. Consistently SMAR1-silenced drug-resistant cells exhibited IkBα-mediated inhibition of p65NFκB and induction of p53-dependent apoptosis. Interestingly, curcumin pretreatment of drug-resistant cells alleviated SMAR1-mediated p65NFκB activation and hence restored doxorubicin sensitivity. Under such anti-survival condition, induction of p53-p300 cross-talk enhanced the transcriptional activity of p53 and intrinsic death cascade. Importantly, promyelocyte leukemia-mediated SMAR1 sequestration that relieved the repression of apoptosis-inducing genes was indispensable for such chemo-sensitizing ability of curcumin. A simultaneous decrease in drug-induced systemic toxicity by curcumin might also have enhanced the efficacy of doxorubicin by improving the intrinsic defense machineries of the tumor-bearer. Overall, the findings of this preclinical study clearly demonstrate the effectiveness of curcumin to combat doxorubicin-resistance. We, therefore, suggest curcumin as a potent chemo-sensitizer to improve the therapeutic index of this widely used anti-cancer drug. Taken together, these results suggest that curcumin can be developed into an adjuvant chemotherapeutic drug.
Formation and reactions of cluster ions from aromatic carboxylic acids together with amino acids (2001)

Abstract The cluster formation of several aromatic carboxylic acids, ferulic acid, vanillic acid, sinapinic acid, and 3,4‐dihydroxybenzoic acid was investigated by means of laser desorption into a supersonic beam followed by multiphoton ionization‐time‐of‐flight mass spectrometry. The formation of not only homogeneous clusters, but also of heterogeneous clusters with some small amino acids was studied. The different neutral clusters formed in the supersonic expansion were ionized by a multiphoton process employing either nano‐ or femtosecond laser pulses. Strong differences in the detection of cluster ions due to the laser pulse length employed for multiphoton ionization were observed. Only femtosecond activation led to mass spectra with intense signals of the cluster ions. In addition, in the case of femtosecond ionization, protonated amino acids were detected in the mass spectra. As direct ionization of the free amino acids is not possible under the chosen ionization conditions because they lack an adequate chromophore, these protonated amino acids are assumed to be formed via an intracluster proton transfer in the heterogeneous dimer and subsequent decay of the ionized cluster (dissociative proton transfer). Such well‐known processes for heterogeneous clusters consisting of a substituted aromatic molecule and small polar solvent molecules may be involved in the matrixassisted laser desorption ionization (MALDI) process.
Measurement of microslips of subsurface fatigue crack faces due to rolling loads (2004)

The development of accurate numerical models of the growth of subsurface fatigue cracks due to rolling load needs reliable experimental data on the actual interactions between the crack faces. The distribution of microslips that occur between the crack faces and the interaction between the crack faces as a function of the magnitude and the position of the load with respect to the crack tip are of particular interest. In this study, the microslips of the faces of a subsurface fatigue crack developed in a railhead made of 900A steel were measured by the grating holographic interferometry (GHI) technique. Reconstruction of each double-exposed hologram made it possible to obtain four interferograms at multiple off-axis angles. On the basis of the interferograms, two-dimensional maps of the displacement vector components were determined, making it possible to calculate the distribution over the crack length of the crack face microslips and the crack opening and closing. A specifically designed experimental stand allowed the application of a stepwise increase in the normal load and consequently stepwise rolling of a constant load along the edge of the specimen.
Wavelength-independent output power from an injection-tunable DBR laser (1994)

Injection-tunable three-section distributed Bragg reflector lasers emitting near 1.55 μm have been fabricated employing bulk 1.48-μm-bandgap InGaAsP in the tuning layer of the phase and Bragg sections. The gain in this material compensates for the increased absorption loss during tuning, which results in a nearly wavelength-independent optical output power. The maximum obtained output power is 28 mW ex facet, with a spectral linewidth around 5 MHz.
Cholestatic Liver Disease (2014)

Abstract Cholestatic liver disease in adults without biliary obstruction encompasses a broad differential diagnosis. Drug-induced cholestasis may be the most common explanation for cholestasis in these patients. Primary biliary cirrhosis is the most common cholestatic liver disease in adults. Primary sclerosing cholangitis is about half as common as primary biliary cirrhosis. Other cholestatic conditions in adults include antimitochondrial antibody (AMA)-negative primary biliary cirrhosis, human immunodeficiency virus (HIV)-related cholangiopathy, and miscellaneous conditions.
An ‘Allosteric-Type’ Effect Demonstrated by a Lectin from The Red Alga <u>Griffithsia Flosculosa</u> (1986)

Journal Article An 'Allosteric-Type' Effect Demonstrated by a Lectin from The Red Alga Griffithsia Flosculosa Get access D J Rogers, D J Rogers School of Pharmacy, Portsmouth Polytechnic, King Henry I Street, Portsmouth, Hants, PO1 2DZ, UK Search for other works by this author on: Oxford Academic Google Scholar M Galander M Galander School of Pharmacy, Portsmouth Polytechnic, King Henry I Street, Portsmouth, Hants, PO1 2DZ, UK Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 38, Issue Supplement_12, December 1986, Page 102P, https://doi.org/10.1111/j.2042-7158.1986.tb14330.x Published: 12 April 2011
Structure determination of a monohydrated piperazinium hydrogenphosphate (1993)

Piperazinium hydrogenphosphate monohydrate, (N 2 C 4 H 12 ).HPO 4 .H 2 O, is composed of a network of isolated PO 4 tetrahedra and organic six-membered rings of piperazine. The two amino groups of the piperazine are protonated and the rings are stacked along the [010] direction. The stability of the framework is ensured by strong O-H linkages between the O atoms from the PO 4 tetrahedra and H atoms from the diamine and water molecules
Reversed‐Phase Isolation of Peptides (2001)

In reversed-phase HPLC, peptides are separated on a hydrophobic stationary phase and eluted with a gradient of increasing organic solvent concentration. Protocols describing the separation of peptides in 5- to 500-pmol quantities via narrow-bore (2-mm-i.d.) or microbore (1-mm-i.d.) columns, as well as for the separation of peptides in quantities <5 pmol are provided in this unit. Capillary HPLC columns require a gradient flow rate of 3 to 5 omponents present in a small sample prior to automated sequencing is possible via the procedures for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry and capillary electrophoresis.