gebhart/patrepeval huggingface dataset:
A Selective Inhibitor Gal‐PUGNAc of Human Lysosomal β‐Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells (2009)

Gal-PUGNAc (see picture), a highly selective inhibitor for beta-hexosaminidases HEXA and HEXB is cell-permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels. Gal-PUGNAc should allow the role of these enzymes to be studied at the cellular level without generating a complex chemical phenotype from concomitant inhibition of O-GlcNAcase.
Detection of lactococcal 936-species bacteriophages in whey by magnetic capture hybridization PCR targeting a variable region of receptor-binding protein genes (2005)

The PCR assays have practical applications at cheese plants for detection of 936-species phages with different RBP and thereby potentially with different host ranges. This knowledge will make it possible to improve starter culture rotation systems in the dairy industry.
Two-photon absorptivities of the all <i>t</i> <i>r</i> <i>a</i> <i>n</i> <i>s</i> α, ω-diphenylpolyenes from stilbene to diphenyloctatetraene via three wave mixing (1979)

Using the interference between the Raman resonances of the solvent and the two-photon absorption resonances of the solute in a three wave mixing experiment (CARS), we have extracted the absolute two-photon absorptivities at single energies for solution samples of the all -trans isomers of α, ω-diphenyl-ethylene, -butadiene, -hexatriene, and -octatetraene. Their absorptivities, for two identical linearly polarized photons in multiples of 10−50 cm4 sec photon−1 molecule−1 at the appropriate total energies (2?, cm−1), are as follows: stilbene, 12.1(0.9) at 38 873 cm−1, diphenylbutadiene, 14.4 (2.0) at 32 900 cm−1, diphenylhexatriene, 43.4 (4.0) at 32 900 cm−1, and diphenyloctatetraene, 61.0 (23.0) at 32 900 cm−1. Numbers in parentheses are standard deviations.
[Lactose intolerance]. (2016)

The most common problem limiting milk consumption worldwide is lactose intolerance (LI), which is defined as the experience of gastrointestinal symptoms due to the intake of lactose-containing food. When symptoms ensue the intake of milk, the condition is referred as milk intolerance, and it may or may not be due to LI. The most common cause of LI is primary lactase deficiency which occurs in 30% of Mexican adults when one glass of milk is consumed (12-18 g of lactose). LI occurs in less than 15% of adults after the intake of this dose of lactose. Another cause of lactose intolerance is due to secondary lactase deficiency, which occurs because lactase is reduced due to diseases that affect the intestinal mucosa. Lactose intolerance can be eliminated or significantly reduced by elimination or reduction of the intake of milk and milk containing products. Recent studies demonstrate that when β-casein-A1 contained in milk is hydrolyzed it produces β-casomorphine-7 which is an opioid associated with milk intolerance.
Brain Interface Device for Long-Term Observation of Mouse Brain Using Two-Photon Uncaging Microscopy (2007)

In this study a brain interface device for long-term two-photon microscopy observation by applying microfluidic device technology using glass or polymer materials. The device is designed to be implanted into a certain part of the skull bone to close the drilled hole, and will enable easy delivery of caged glutamate into the brain tissue without any degradation of microscopy observation.
Synthesis of 19,19,20,20,20-pentadeuteriolipoxin A4 methyl ester and 19,19,20,20,20-pentadeuteriarachidonic acid. Agents for use in the quantitative detection of naturally occurring eicosanoids (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 19,19,20,20,20-pentadeuteriolipoxin A4 methyl ester and 19,19,20,20,20-pentadeuteriarachidonic acid. Agents for use in the quantitative detection of naturally occurring eicosanoidsB. E. Marron, R. A. Spanevello, M. E. Elisseou, C. N. Serhan, and K. C. NicolaouCite this: J. Org. Chem. 1989, 54, 23, 5522–5527Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/jo00284a025https://doi.org/10.1021/jo00284a025research-articleACS PublicationsRequest reuse permissionsArticle Views940Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Oxidation of Acetylated Guanosine by 3,3-Disubstituted 1,2-Dioxetanes through Nucleophilic Attack on the Peroxide Bond: Model Studies on the Oxidative DNA Damage by Reactive Peroxides (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of Acetylated Guanosine by 3,3-Disubstituted 1,2-Dioxetanes through Nucleophilic Attack on the Peroxide Bond: Model Studies on the Oxidative DNA Damage by Reactive PeroxidesWaldemar Adam and Alexander TreiberCite this: J. Am. Chem. Soc. 1995, 117, 10, 2686–2693Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ja00115a002https://doi.org/10.1021/ja00115a002research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Static particle sorting in 1D optical lattice (2006)

We demonstrate how the simple one-dimensional optical lattices can be used to sort micron-sized particles. Experimentally we focused on the simplest case where the periodical structure is created by an interference of two co-propagating beams and third non-interfering beam is used to compensate the radiation pressure caused by the previous two beams. We proved, that this geometry can be used for fast and efficient static sorting of microscopic objects without fluid flow.
Theoretical Characterization of the Vibrational Properties at the Aluminum/<i>trans</i>-Polyacetylene Interface (1997)

We investigate theoretically the geometric structure and vibrational properties of complexes of polyenes with aluminum atoms that constitute model systems for the species formed at the interface between aluminum and polyacetylene. The calculations are performed with two quantum-mechanical techniques: ab initio Hartree−Fock and density functional theory in the local spin density approximation. These methods are first applied to a polyene molecule, all-trans octatetraene, and the calculated vibrational spectra are compared to existing experimental and theoretical data. The molecule is then made to interact with two aluminum atoms in various configurations. Since the metal atoms form covalent bonds with carbon atoms in the central part of octatetraene, strong geometric modifications occur along the conjugated system, which in turn deeply affect the vibrational spectra. These results allow us to derive the expected infrared signature of the chemical species present at the interface.
High-velocity Krypton Z-pinch Implosions On Saturn (2005)

The authors have explored the high velocity implosion limit of krypton gas-puff z-pinch implosions in an effort to efficiently generate K-shell radiation from high-Z elements. Using Saturn, a fast electrical generator, they imploded krypton gas-puff z pinches attaining implosion velocities as high as 125 cm/{mu}s. They observed the magneto Raleigh-Taylor instability in the fastest implosions. Despite the high implosion velocities, the plasma was never observed to attain the He-like ionization state, most likely because of inadequate density giving too long an ionization time. The dominant ionization state at peak compression was Ne-like Kr. They measured radiation yields as high as 100 J from Kr K{sub {alpha}} transitions. They used two different nozzle configurations for these experiments: 2.5-cm mean diameter nozzles and 3.5-cm mean diameter nozzles. Both sets of nozzles had exits with a 1-cm width. These nozzles are designed to have a 5-degree inward tilt to reduce the effect of zippering. The gas valve timing was adjusted relative to the generator so that the implosion occurred during the time when the gas density was increased. This also acted to reduce the effect of zippering. VUV preionization of the Kr was used for all of these shots. The pinch length wasmore » 2 cm. Current in the z pinch was measured with both B-dot current monitors and piezoelectric pressure transducers.« less
[A case of tension pneumothorax after general anesthesia]. (2011)

A 72-year-old male patient was scheduled for extirpation of the right kidney and ureter with partial resection of the bladder. Anesthesia was maintained with general and epidural anesthesia. After the end of surgery, he awoke and his spontaneous ventilation seemed to be good. Soon after extubation, he developed cyanosis and circulatory arrest. Immediately cardiopulmonary resuscitation was performed and regular beating of the heart was restored about 6 minutes after cardiac arrest. A chest x-ray showed pneumothorax on right side and he was diagnosed as tension pneumothorax caused by injury of the right diaphragmatic pleura during surgery. Pneumothorax was improved by drainage of the right thoracic cavity, and he was transferred to the intensive care unit. After 4 days of hypothermic therapy, he showed no neurological deficit and recurrence of pneumothorax was not observed. We should be aware of the occurrence of pneumothorax during perioperative period in the patients who underwent surgical procedure in the vicinity of the diaphragm.
First long-term study of particle number size distributions and new particle formation events of regional aerosol in the North China Plain (2011)

Abstract. Atmospheric particle number size distributions (size range 0.003–10 μm) were measured between March 2008 and August 2009 at Shangdianzi (SDZ), a rural research station in the North China Plain. These measurements were made in an attempt to better characterize the tropospheric background aerosol in Northern China. The mean particle number concentrations of the total particle, as well as the nucleation, Aitken, accumulation and coarse mode were determined to be 1.2 ± 0.9 × 104, 3.6 ± 7.9 × 103, 4.4 ± 3.4 × 103, 3.5 ± 2.8 × 103 and 2 ± 3 cm−3, respectively. A general finding was that the particle number concentration was higher during spring compared to the other seasons. The air mass origin had an important effect on the particle number concentration and new particle formation events. Air masses from northwest (i.e. inner Asia) favored the new particle formation events, while air masses from southeast showed the highest particle mass concentration. Significant diurnal variations in particle number were observed, which could be linked to new particle formation events, i.e. gas-to-particle conversion. During particle formation events, the number concentration of the nucleation mode rose up to maximum value of 104 cm−3. New particle formation events were observed on 36% of the effective measurement days. The formation rate ranged from 0.7 to 72.7 cm−3 s−1, with a mean value of 8.0 cm−3 s−1. The value of the nucleation mode growth rate was in the range of 0.3–14.5 nm h−1, with a mean value of 4.3 nm h−1. It was an essential observation that on many occasions the nucleation mode was able to grow into the size of cloud condensation nuclei (CCN) within a matter of several hours. Furthermore, the new particle formation was regularly followed by a measurable increase in particle mass concentration and extinction coefficient, indicative of a high abundance of condensable vapors in the atmosphere under study.
Reappraisal of non‐invasive management strategies for uninvestigated dyspepsia: a cost‐minimization analysis (2002)

As the H. pylori prevalence, the likelihood of peptic ulcer disease and the proportion of ulcers due to H. pylori decrease, empirical proton pump inhibitor becomes less costly than the test-and-treat strategy for the management of uninvestigated dyspepsia. Given the modest cost differential between the strategies, the test-and-treat strategy may be favoured if patients without peptic ulcer disease derive long-term benefit from H.pylori eradication.
Genetic Detection of Cerebral Dysfunction (1980)

Batshaw and his colleagues in this issue have reported on a pedigree in which female carriers of the sex-linked gene for ornithine transcarbamylase deficiency, as identified through pedigree analysis and testing of protein tolerance, have lower IQ scores than their protein-tolerant siblings. This is particularly interesting because almost nothing is known about the role of metabolism in differences in IQ within the normal range of scores. It is intriguing to consider the possibility that carriers of genes for other metabolic disorders (autosomal recessive as well as X-linked) may be at increased risk for cerebral dysfunction. These dysfunctions may include the . . .
Growth mechanism of vertically aligned SnSe nanosheets via physical vapour deposition (2014)

The growth mechanism of SnSe nanosheets synthesized by physical vapour deposition was elucidated in detail based upon crystal structure and surface energy.
Comparison of photostabilization in acrylic/urethane and acrylic/melamine coatings containing hindered amines and ultraviolet absorbers (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of photostabilization in acrylic/urethane and acrylic/melamine coatings containing hindered amines and ultraviolet absorbersDavid R. Bauer, Mary J. Dean, and John L. GerlockCite this: Ind. Eng. Chem. Res. 1988, 27, 1, 65–70Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ie00073a014https://doi.org/10.1021/ie00073a014research-articleACS PublicationsRequest reuse permissionsArticle Views294Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Turbulence-assisted shear exfoliation of graphene using household detergent and a kitchen blender (2014)

To facilitate progression from the lab to commercial applications, it will be necessary to develop simple, scalable methods to produce high quality graphene. Here we demonstrate the production of large quantities of defect-free graphene using a kitchen blender and household detergent. We have characterised the scaling of both graphene concentration and production rate with the mixing parameters: mixing time, initial graphite concentration, rotor speed and liquid volume. We find the production rate to be invariant with mixing time and to increase strongly with mixing volume, results which are important for scale-up. Even in this simple system, concentrations of up to 1 mg ml(-1) and graphene masses of >500 mg can be achieved after a few hours mixing. The maximum production rate was ∼0.15 g h(-1), much higher than for standard sonication-based exfoliation methods. We demonstrate that graphene production occurs because the mean turbulent shear rate in the blender exceeds the critical shear rate for exfoliation.
A miniature, battery-powered, pyroelectric detector-based differential infrared absorption sensor for ambient concentrations of carbon dioxide (1981)

Abstract We describe a dual-wavelength, non-dispersive, spectro-radiometer that is optimized to measure carbon dioxide. This CO2 sensor was designed for use with a portable system for measuring water loss and photosynthesis in plant leaves. The elements of the sensor include: a highly insulated, miniature, blackbody source of infrared radiation; an external, folded, optical-absorption cell; alternating, narrow-band pass filters; and a commercial pyroelectric detector. Detector signals are filtered, amplified, and fed to a processing system based on a voltage-to-frequency converter that computes a ratio of the absorbed wavelength to a non-absorbed wavelength. The system, minus battery, weighs less than 1.5 kg and its optical head volume is 800 cm. The sensor requires 10 W of power from a 12-V source, and has an accuracy of about ±0.5 ppm at ambient (330 μ1/1) concentrations.
Modification of catalysts for propylene polymerization: Alcohols and lewis bases (1984)

Abstract A series of compounds were examined as modifiers for the high activity supported catalyst TiCl 4 /MgCl 2 –AlEt 3 for isospecific propylene polymerization. The list included two aromatic acid esters, 21 various Lewis bases, and 12 alcohols. A convenient graphic method is described for comparing the performance of different modifiers by plotting experimental results in coordinates “relative activity‐isotactic index” and a kinetic rationale for this evaluation is presented. Aromatic acid esters exhibit much better performance than the bulk of Lewis bases but some sterically demanding aromatic alcohols show behavior show similar to that of the esters.
2104 Differences in hemodynamics in the infra-renal aorta in mice and men: implications for the localization of Abdominal Aortic Aneurysms (AAA) (2008)

Introduction In humans, abdominal aortic aneurysms (AAA) develop inferior to the renal arteries and end above the aortic bifurcation. The aorta superior to the renal artery is remarkably spared. Conversely, mouse models of AAA (including ApoE-/or LDL Receptor-/mice infused with AngII) exhibit AAA formation exclusively in the aorta superior to the renal arteries. Oscillatory wall shear stress (WSS) has been shown be important in the localization of atherosclerosis and has been implicated in AAA pathogenesis. Humans have a triphasic flow pattern (forward-reverseforward) in the infra-renal aorta that results in oscillatory WSS in that vascular segment (Figure 1). Hemodynamics of the human aorta have been studied extensively but similar studies in mice have not been done.
Loop L1 (odd level) BsaI type IIS cloning into pCk vectors v2 (2019)

Protocol based on: Pollak B, Cerda A, Delmans M, et al (2019) Loop assembly: a simple and open system for recursive fabrication of DNA circuits. New Phytol 222:628–640 https://doi.org/10.1111/nph.15625
A Neural Estimator for Cylinder Pressure and Engine Torque (1999)

<div class="htmlview paragraph">The paper presents a new method based on neural networks to model the dynamic behavior of combustion pressure in SI engine cylinders, represented only by conventional input-output data. The approach is based on a functional representation of the pressure curve. The function parameters are adjusted by training a static neural network (SNN) for each working cycle. These parameters resp. “weights” are used in the following as reference pressure feature sequences. The sequences are simulated using time delay neural network (TDNN) as functions of engine speed, manifold pressure, ignition time and A/F ratio. The developed models can be used as stand alone models or as submodels within a global structure. It can be integrated as a real-time model in a HIL simulator to stimulate an ECU or implemented within an ECU for torque estimation. Performance of the proposed modeling strategy is verified by comparing experimental data from a test bench to real-time simulation results.</div>
Toxicity of sediments from lead–zinc mining areas to juvenile freshwater mussels (<i>Lampsilis siliquoidea</i>) compared to standard test organisms (2014)

Sediment toxicity tests compared chronic effects on survival, growth, and biomass of juvenile freshwater mussels (28-d exposures with Lampsilis siliquoidea) to the responses of standard test organisms-amphipods (28-d exposures with Hyalella azteca) and midges (10-d exposures with Chironomus dilutus)-in sediments from 2 lead-zinc mining areas: the Tri-State Mining District and Southeast Missouri Mining District. Mussel tests were conducted in sediments sieved to <0.25 mm to facilitate recovery of juvenile mussels (2-4 mo old). Sediments were contaminated primarily with lead, zinc, and cadmium, with greater zinc and cadmium concentrations in Tri-State sediments and greater lead concentrations in southeast Missouri sediments. The frequency of highly toxic responses (reduced 10% or more relative to reference sites) in Tri-State sediments was greatest for amphipod survival (25% of samples), midge biomass (20%), and mussel survival (14%). In southeast Missouri sediments, the frequency of highly toxic samples was greatest for mussel biomass (25%) and amphipod biomass (13%). Thresholds for metal toxicity to mussels, expressed as hazard quotients based on probable effect concentrations, were lower for southeast Missouri sediments than for Tri-State sediments. Southeast Missouri sites with toxic sediments had 2 or fewer live mussel taxa in a concurrent mussel population survey, compared with 7 to 26 taxa at reference sites. These results demonstrate that sediment toxicity tests with juvenile mussels can be conducted reliably by modifying existing standard methods; that the sensitivity of mussels to metals can be similar to or greater than standard test organisms; and that responses of mussels in laboratory toxicity tests are consistent with effects on wild mussel populations.