gebhart/patrepeval huggingface dataset:
New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis (2012)

A new synthetic pathway was devised to reach tetrasubstituted 3-arylthiophene 2-carboxylic acids in a three-step solid-phase synthesis. This very efficient methodology provided more than 20 new compounds that were evaluated for their ability to inhibit protein farnesyltransferase from different species as well as Trypanosoma brucei and Plasmodium falciparum proliferation.
[Intraoperative localization of recurrent pancreatic insulinoma-a resected case of the metastatic lesions in the residual pancreas and the lymph node]. (2011)

We describe herein a 39-year-old woman with tumor recurrence in the residual pancreas and metastasis to the lymph node about 5 years after an eneclation for insulinoma in the body of the pancreas. A certain day in the morning in June 2002, she was immediately admitted to our hospital due to impairment of consciousness based hypoglycemia. On diagnostic imaging including an arterial stimulation venous sampling, localization of the recurrent lesions was not identified. In October 2002, we underwent laparotomy for the purpose of localization of the recurrent lesions and treatment. During the operation, peripheral blood glucose level, portal blood glucose level and portal insulin level were measured periodically. The mobilization started from the tail of the pancreas. Blood glucose levels were gradually elevated during the mobilization. The pancreas was mobilized to the right edge of the portal vein and was resected. Histopathological diagnosis was recurrent insulinoma in a peripancreatic lymph node and intra-pancreatic subcapsular tumor embolization. Postoperative course was uneventful. More than 8 years after surgery, she is doing well without signs of recurrence.
The effect of substituents on the occurrence of polymorphism in diaminodicyanopyrazine dyes (2008)

Lamotrigine is an anticonvulsant drug with low water solubility. In order to enhance it, lamotrigine salts of four different counterions were prepared. Six structures have been solved from single crystal X-ray diffraction data. Four of these salts crystallized in P21/c C450
Chemical studies of carbohydrates (II) On the mechanism of the conversion of a glucose derivative into a pyridazine compound (1975)

Abstract The formation of 3‐(2′,2′‐dimethyl‐1′,3′‐dioxolan‐4′‐yl)pyridazine ( 4 ) by reacting 1,2:5,6‐di‐ O ‐isopropylidene‐3‐ O ‐( p ‐tolylsulfonyl)‐α‐D‐glucofuranose ( 1 ) with hydrazine hydrate via the intermediate 3‐deoxy‐1,2:5,6‐di‐ O ‐isopropylidene‐α‐D‐ erythro ‐hex‐3‐enofuranose ( 3 ) is explained by a mechanism, involving an initial attack of the hydrazine molecule at position 4 in compound 3 , a subsequent ring opening by fission of the C 4 O bond and a ring closure by formation of a NC 1 bond.
Cyclin D1 Is a Selective Modifier of Androgen-dependent Signaling and Androgen Receptor Function (2011)

D-type cyclins regulate cellular outcomes in part through cyclin-dependent, kinase-independent mechanisms that modify transcription factor action, and recent in vivo studies showed that cyclin D1 associates with a large number of transcriptional regulators in cells of the retina and breast. Given the frequency of cyclin D1 alterations in cancer, it is imperative to delineate the molecular mechanisms by which cyclin D1 controls key transcription factor networks in human disease. Prostate cancer was used as a paradigm because this tumor type is reliant at all stages of the disease on androgen receptor (AR) signaling, and cyclin D1 has been shown to negatively modulate AR-dependent expression of prostate-specific antigen (KLK3/PSA). Strategies were employed to control cyclin D1 expression under conditions of hormone depletion, and the effect of cyclin D1 on subsequent androgen-dependent gene expression was determined using unbiased gene expression profiling. Modulating cyclin D1 conferred widespread effects on androgen signaling and revealed cyclin D1 to be a selective effector of hormone action. A subset of androgen-induced target genes, known to be directly regulated by AR, was strongly suppressed by cyclin D1. Analyses of AR occupancy at target gene regulatory loci of clinical relevance demonstrated that cyclin D1 limits AR residence after hormone stimulation. Together, these findings reveal a new function for cyclin D1 in controlling hormone-dependent transcriptional outcomes and demonstrate a pervasive role for cyclin D1 in regulating transcription factor dynamics.
Optimization of stall regulated rotors (1994)

The present work deals with the optimization of stall regulated rotors for wind turbines. Two different optimization methods are presented. The first method is a single design point optimization procedure, whereas the second is a multi pointed optimization technique which is founded on a general optimization algorithm. The use of an optimization algorithm offers the possibility to treat complex optimization problems concerning the entire rotor geometry. The two methods are compared through design of a 20 kW rotor showing good agreement. By use of the optimization algorithm, different aspects of modern wind turbine design layout are investigated. The improvement of the annual energy production by optimizing the airfoil characteristics in addition to the blade chord and twist has been found marginal compared to a case where a standard NACA 634x airfoil family is used. The optimal ratio of swept area to rated power is found depending strongly on the value of the specified maximum loads. Optimization of rotors to specific wind regimes has not been found favorable. In general, the results show that the optimization algorithm is an useful aid to the design.
The Effect of Smoking and Periodontal Treatment on Salivary Composition in Patients With Established Periodontitis (1999)

Subjects with established periodontitis exhibited elevated concentrations of salivary electrolytes and proteins. Within this study group, smokers exhibited greater disease level but reduced sodium, calcium, and magnesium concentrations. Smokers responded favorably to treatment. The clinical improvement eliminated the differences in salivary composition.
Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s (2020)

The ability of cancer cells to ensure T-cell exclusion from the tumor microenvironment is a significant mechanism of resistance to anti-PD-1/PD-L1 therapy. Evidence indicates crucial roles of Batf3-dependent conventional type-1 dendritic cells (cDC1s) for inducing antitumor T-cell immunity; however, strategies to maximize cDC1 engagement remain elusive. Here, using multiple orthotopic tumor mouse models resistant to anti-PD-L1-therapy, we are testing the hypothesis that in situ induction and activation of tumor-residing cDC1s overcomes poor T-cell infiltration. In situ immunomodulation with Flt3L, radiotherapy, and TLR3/CD40 stimulation induces an influx of stem-like Tcf1<sup>+</sup> Slamf6<sup>+</sup> CD8<sup>+</sup> T cells, triggers regression not only of primary, but also untreated distant tumors, and renders tumors responsive to anti-PD-L1 therapy. Furthermore, serial in situ immunomodulation (ISIM) reshapes repertoires of intratumoral T cells, overcomes acquired resistance to anti-PD-L1 therapy, and establishes tumor-specific immunological memory. These findings provide new insights into cDC1 biology as a critical determinant to overcome mechanisms of intratumoral T-cell exclusion.
Design of a Genomics Curriculum: Competencies for Practicing Pathologists (2015)

We present a genomics curriculum designed as a first step toward providing practicing pathologists with the competencies needed to practice successfully.
Hydroxy‐Morphinane. 9. Mitteilung. Versuche zur Racemisierung optisch aktiver 1‐(p‐Hydroxybenzyl)‐1,2,3,4,5,6,7,8‐octahydro‐isochinoline (1956)

Abstract Racemic or optically active 1‐(p‐hydroxybenzyl)‐1,2,3,4,5,6,‐7,8‐octahydroisoquinolines (I, Ia or Ib) as well as their O‐methyl‐ethers (II, IIa or IIb) are dehydrogenated in good yields to 5,6,7,8‐tetrahydroisoquinoline derivatives at higher temperature. The conversion of the latter into racemic 1‐(p‐hydroxybenzyl)‐1,2,3,4,5,6,‐7,8‐octahydroisoquinoline (I) or to the racemic O‐methyl ether (II) is achieved either by reduction with sodium in isoamyl alcohol or by catalytic reduction of the quaternary bromobenzylates by way of the tertiary N‐benzyl‐1,2,3,4,5,6,7,8‐octahydroisoquinolines.
Separation of the Pyro- and Piezoelectric Response of Electroactive Polymers for Sensor Applications (2006)

One of the main problems for the use of ferroelectric materials for sensor applications, especially for tactile sensors, is the separation of the pyro- and piezoelectric responseproduced by temperature and pressure changes, respectively. We present two different approaches to achieve this goal. The first approach is based on the study of the signal in the frequency domain and uses a signal processing to separate the approach is based on a double layer configuration of electroactive polymers. In this case, the piezoelectric response is equal in each layer, whereas, the pyroelectric response dominates in the layer exposed to the temperature variations. The pyro- and piezoelectric responses are separated by estimating the diference between the signals of two layers and the signal from one of the layers, correspondingly.
Growth hormone-releasing hormone and extra-pituitary tumorigenesis: therapeutic and diagnostic applications of growth hormone-releasing hormone antagonists (2003)

Growth hormone-releasing hormone (GHRH) regulates growth hormone release from the pituitary. However, in addition to this neuroendocrine action, much evidence implies an additional role for GHRH in carcinogenesis in non-pituitary tissues. This role of GHRH in cancer development appears to be due to the operation of several mechanisms, which involve the regulation of the growth hormone-dependent hepatic insulin-like growth factor I (IGFI) production, tumoural IGF-I and IGF-II secretion and direct action of GHRH on tumour cells by autocrine and/or paracrine pathways. This review summarises the available information regarding the role of GHRH in tumorigenesis with special emphasis on the direct action of GHRH in primary and experimental cancers.
Towards cleaner combustion engines through groundbreaking detailed chemical kinetic models (2011)

In the context of limiting the environmental impact of transportation, this critical review discusses new directions which are being followed in the development of more predictive and more accurate detailed chemical kinetic models for the combustion of fuels. In the first part, the performance of current models, especially in terms of the prediction of pollutant formation, is evaluated. In the next parts, recent methods and ways to improve these models are described. An emphasis is given on the development of detailed models based on elementary reactions, on the production of the related thermochemical and kinetic parameters, and on the experimental techniques available to produce the data necessary to evaluate model predictions under well defined conditions (212 references).
Demonstration of massive wavelength-division multiplexing over transoceanic distances by use of dispersion-managed solitons (2000)

By combining a special dispersion map that has nearly constant path-average dispersion, a hybrid amplification scheme involving backward-pumped Raman gain, and sliding-frequency guiding filters, we have demonstrated massive wavelength-division multiplexing at 10 Gbits/s per channel, error free (bit-error rate, </=1x10(-9) for all channels), without the use of forward error correction, over greater than 9000 km, using dispersion-managed solitons. The number of channels (27) was limited only by a temporary lack of amplifier power and gain flatness. Terabit capacities are to be expected in the near future.
Xis Protein Binding to the Left Arm Stimulates Excision of Conjugative Transposon Tn<i>916</i> (2002)

Tn916 and related conjugative transposons are clinically significant vectors for the transfer of antibiotic resistance among human pathogens, and they excise from their donor organisms using the transposon-encoded integrase ((Tn916)Int) and excisionase ((Tn916)Xis) proteins. In this study, we have investigated the role of the (Tn916)Xis protein in stimulating excisive recombination. The functional relevance of (Tn916)Xis binding sites on the arms of the transposon has been assessed in vivo using a transposon excision assay. Our results indicate that in Escherichia coli the stimulatory effect of the (Tn916)Xis protein is mediated by sequence-specific binding to either of its two binding sites on the left arm of the transposon. These sites lie in between the core and arm sites recognized by (Tn916)Int, suggesting that the (Tn916)Xis protein enhances excision in a manner similar to the excisionase protein of bacteriophage lambda, serving an architectural role in the stabilization of protein-nucleic acid structures required for strand synapsis. However, our finding that excision in E. coli is significantly enhanced by the host factor HU, but does not depend on the integration host factor or the factor for inversion stimulation, defines clear mechanistic differences between Tn916 and bacteriophage lambda recombination.
TUMOR SIZE ESTIMATION BY PET FDG IMAGING (1992)

Rege, S.; Wong, W. L.; Chaiken, L.; Hoh, C. K.; Choi, Y.; Lufkin, R. B.; Maddahi, J.; Phelps, M. E.; Hawkins, R. A. Author Information
1409: Impact of Apical Surgical Margin Status on Disease Progression in Men with Localized Prostate Cancer Treated with Radical Retropubic Prostatectomy (2007)

CONCLUSIONS: All men with PT2 disease do not have the same risk for PSAR. In our analysis tumor volume, but not pathologic tumor stage, predicted time to PSAR. As our understanding of PSAR grows and the use of PSA kinetics and time to PSA relapse become more important parameters, the use of tumor volume will have significant implications in predicting cancer control outcomes in men with organ confined disease.
Laser Polishing of Fused Silica (2010)

A novel process for polishing fused silica with CO2-laser radiation is presented. Due to the increasing demand in the optics industry to use aspherical or freeform lenses in optical systems new manufacturing processes for these geometries are required. Laser polishing reduces the roughness of fused silica surfaces to Ra<6 nm (Rms<10 nm [1]). The processing rates - up to 1 cm²/s - are several times faster than conventional polishing techniques especially for geometries like aspheres or freeform optics. The laser radiation is absorbed in a thin layer of about 40 µm thickness. The temperature of this thin layer rises and therefore the viscosity is lowered. Due to the surface tension material flows from the peaks to the valleys and the surface is polished. Material removal is not desired. The samples are preheated to avoid cracks resulting from thermal stresses. Polishing results on plane samples and on spherical lenses are presented.
<title>Fitting of surfaces to scattered data</title> (1992)

Reconstruction of shapes from partial information is a problem arising in many scientific and engineering applications. We present a method for reconstructing a two-dimensional manifold from an unstructured collection of sampled points. The algorithm consists of two major steps. In the first step, we estimate the topological type of the manifold and also obtain a crude estimate of its geometry. In the second step, we improve the fit of the estimate to the data points, while keeping the topological type fixed.
Start-up plan for the first NIF laser bundle: transition from single Beamlet prototype to 192-beamline laser facility (1999)

The compact multi-pass laser design and the extensive use of optical component assemblies as line replaceable units are essential to achieve the cost efficiency of the NIF design. These design philosophies require a new approach to start-up operation of the NIF 192-beam-line high-energy laser compared to existing fusion laser facilities. The limited access on the beam-line optics and the limited on-line verification and maintenance capability require that extensive component verification and alignment takes place in off-line facilitates before the LRU's are installed in the laser structure.
ChemInform Abstract: Asymmetric Syntheses of Isostegane Derivatives Using Trivalent Iodine Reagents. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Atomic Structure of Adsorbed Sulfate on Rh(111) in Sulfuric Acid Solution (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAtomic Structure of Adsorbed Sulfate on Rh(111) in Sulfuric Acid SolutionLi-Jun Wan, Shueh-Lin Yau, and Kingo ItayaCite this: J. Phys. Chem. 1995, 99, 23, 9507–9513Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/j100023a031https://doi.org/10.1021/j100023a031research-articleACS PublicationsRequest reuse permissionsArticle Views474Altmetric-Citations182LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Speckle suppression of laser light using liquid crystals aligned by photoisomerization of dye molecules (2002)

For energy applications of high-power laser systems, uniform patterns are especially important in inertial confinement fusion research. We have demonstrated alignment control of liquid crystals using photoisomerization induced by polarized ultraviolet light to fabricate a polarization control plate. A glass substrate of a liquid-crystal cell, coated with polyvinyl alcohol doped with azo dye, was illuminated with a linearly polarized third harmonic of a Nd:YAG laser light. We confirmed the alignment of liquid crystals within the illuminated region dependent on the polarization direction of the ultraviolet light through the photoisomerization of azo dye molecules. Reduction of laser speckle pattern contrast by a polarization control plate was discussed.
Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium (2003)

Cyclosporine A (CsA) is associated with the development of cardiovascular toxicity in transplant patients but can exert myocardial protection against ischemia/reperfusion damages. We examined in a rat model of chronic CsA administration whether subtle variations in the NO pathway could account for these opposite effects. CsA treatment rapidly led to an increase in myocardial Hsp90 expression promoting the recruitment of Akt and calcineurin, thereby promoting eNOS activation through Ser1177 phosphorylation and Thr495 dephosphorylation, respectively. This was associated with an increase in myocardial VEGF expression and led to anti-apoptotic effects in isolated cardiac myocytes. Upon longer CsA exposure, cardiac toxicity developed, as documented by the infiltration of connective tissue and the increase in iNOS expression. These later effects were associated with a dramatic decrease in the abundance and scaffold function of Hsp90, thereby unraveling the key role of Hsp90 in governing CsA effects.
Process Image Analysis using Big Data, Machine Learning, and Computer Vision (2019)

Within the DOE complex, 3013 canisters are used to store Pu-bearing waste. Wall penetration due to corrosion, specifically stress corrosion cracking, is considered to be the most likely cause of failure over the 50-year lifetime of the canisters. This project has 2 objectives: The first is the development of machine learning algorithms to identify the presence of corrosion from a very large set of images generated by laser confocal microscope scanning of 3013 canister used to store Pu oxides. This portion of the LDRD constitutes image analysis of a metal surface for the presence of corrosion. The image processing algorithms developed for this project will provide a suitable basis for analysis of other types of corrosion data, which can be produced in vast quantities using modern devices. The second component of the LDRD consists of the development of machine learning algorithms that obtain molecular mechanics force-fields from ab-initio Density Functional Theory (DFT) calculations for corrosive attack by chlorides on 304L or 316L stainless steel. The goal of this latter component is to determine means for mitigating corrosion on a fundamental level, including coatings, welding methods, metal composition, etc. Force-field modeling is necessary for this endeavor because the incipience and progression of corrosion is the governed by molecular structures, grain boundaries, dislocations and surface structures represented by large numbers of atoms. Although DFT calculations are extremely adept at describing molecular scale processes, they are computationally expensive making them ill-suited for calculations of more than several hundred atoms, especially for the repeated applications inherent in material design. Fortunately, force-field methods provide an avenue for viable molecular-scale calculations involving the numbers of atoms involved in corrosion processes. The accuracy of the force-field calculations depends strongly on the accuracy of the force-field model, which is extremely difficult and time-consuming to derive from either data or ab-initio calculations. The use of machine learning algorithms has the potential to make the calculation of force-fields much more efficient but has not been explored significantly for corrosion processes. If shown to be viable, the technique would have wide -ranging impact on design of corrosion resistant materials and on the mitigation of corrosion in existing process systems.
A Pilot Study of Salix SST (Saliva-stimulating Lozenges) in Post-irradiation Xerostomia (1998)

Relief from the effects of radiation-induced xerostomia resulting from use of saliva-stimulating lozenges (Salix) has been subjectively evaluated. Ten patients took Salix as required for 7 days; and self-assessed using analogue scales before and after treatment. There was a marked and statistically significant improvement in the dryness and general comfort of the mouth, and beneficial effects on eating, sleeping and speech.