gebhart/patrepeval huggingface dataset:
Histamine increases the expression of LOX‐1 via H2 receptor in human monocytic THP‐1 cells (2001)

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a member of the scavenger receptor family, and is known to be expressed in monocytes/macrophages. We investigated the effect of histamine on the expression of LOX-1 in cells of the human monocytic leukemia cell line THP-1. Histamine as well as forskolin and dibutyryl cyclic AMP (Bt2-cAMP) stimulated the THP-1 monocytes to express the LOX-1 gene at the transcription level. This histamine effect on LOX-1 gene expression, via the histamine H2 receptor-mediated cAMP signal transduction pathway, was reduced after differentiation of the cells into macrophages, even though forskolin and Bt2-cAMP still enhanced the gene expression. The alteration of the responsiveness of LOX-1 expression to histamine was related to suppressed expression of the H2 receptor in THP-1 macrophages. The switch of the predominant class of histamine receptors between H1 and H2 would modulate the effects of histamine on LOX-1 gene expression in monocytes and macrophages, and therefore, would play a certain role in the inflammatory aspects of atherogenesis.
Cycloadditionen mit dipolaren Zwischenstufen, II. Dipolare Produkte aus Allencarbonsäureestern (1979)

Cycloadditions with Dipolar Intermediates, II. ‐ Dipolar Products from Allenecarboxylates The allenecarboxylates 2c‐c , and in some cases also the allenetri‐ and allenedicarboxylates 2d and 2e, f react with phosphanes, pyridines, and nucleophilic carbenes or their precursors to give the dipolar 1:1 adducts 10, 11 and 16,18, 20 , respectively. These “carbene allene dipoles” represent stable derivatives of trimethylenemethane.
A method for the elimination of the spurious mode of backward-wave oscillations (1957)

Summary form only given. For a given power output and voltage range, the minimum length of a backward-wave oscillator can be calculated from published data from any normal range of circuit loss and space charge regimes. As this circuit increases in length the rf oscillations become more insensitive to variations of beam current, but soon a point is reached where a new line appears in the spectrum at a slightly lower frequency. This new frequency corresponds to a second solution of the boundary value equation; and because the system is already in a state of oscillation, nonlinear mixing very rapidly fills the spectrum on either side of the main oscillation as the circuit length or the current is increased beyond that point. Thus, the optimum length of the circuit is a matter of compromise unless the starting current of the spurious mode can be appreciably increased or, as is indicated in this paper, can, in fact, be made infinite.
Enhanced magnification angiography including phase-contrast effect using a 100-μm focus x-ray tube (2005)

A microfocus x-ray tube is useful in order to perform magnification digital radiography including phase-contrast effect. The 100-μm-focus x-ray generator consists of a main controller for regulating the tube voltage and current and a tube unit with a high-voltage circuit and a fixed anode x-ray tube. The maximum tube voltage, current, and electric power were 105 kV, 0.5 mA, and 50 W, respectively. Using a 3-mm-thick aluminum filter, the x-ray intensity was 26.0 μGy/s at 1.0 m from the source with a tube voltage of 60 kV and a current of 0.50 mA. Because the peak photon energy was approximately 38 keV using the filter with a tube voltage of 60 kV, the bremsstrahlung x-rays were absorbed effectively by iodine-based contrast media with an iodine K-edge of 33.2 keV. Magnification angiography including phase-contrast effect was performed by three-time magnification imaging with a computed radiography system using iodine-based microspheres 15 μm in diameter. In angiography of non-living animals, we observed fine blood vessels of approximately 100 μm with high contrasts.
IFR guiding experiments (1985)

We have developed a new technique for electrostatically guiding high-current electron beams in accelerators and for IFR (ion focused regime) propagation experiments. The new method allows transport of IREBs over curved paths for applications in circular accelerators such as Sandia's recirculating linac. This method uses a low-energy electron beam in place of a laser to ionize the channel and thereby allows the use of any background gas desired instead of being restricted to the use of organics with high-photoionization cross sections. A weak longitudinal magnetic field is applied to confine the low-energy beam, enabling one to precisely define the ionization channel. Using this method, we have guided a 1.2 MeV beam with currents exceeding 20 kA over a 3-m straight path. In these experiments with high nu/..gamma.. beams, we observed the inductive erosion and also studied the effects of ion mass on channel stability. Both effects can be important for accelerator applications. The transport of high-current beams around a 90/sup 0/ bend is described in a companion paper. 8 figs.
Investigation of Impact Response and Fracture of the Human Femur by Finite Element Modeling (1976)

<div class="htmlview paragraph">The mechanical response of a plane strain finite element model depicting an axial midsection of a human femur is investigated for both static and dynamic condylar loadings. An elastic bi-medium structure composed of compact and cancellous bone is used to represent the femur.</div> <div class="htmlview paragraph">Critically stressed locations are identified and associated static and dynamic load levels which may initiate femur fracture are calculated. The predicted fracture sites and load levels are found to be in good agreement with published data for cadaver knee impacts. An important conclusion of this investigation is that the peak stress or strain and therefore femoral tolerance significantly depends on the impact duration due to stimulation of structural resonances.</div>
From the Editor: Pushing Electrons (and Sometimes Ions or Molecules) (2002)

Our Society draws from a community of scientists and engineers with a wide spectrum of technical backgrounds and research interests. Nonetheless, a common thread weaves through the Society membership in that the vast majority of us study electron transport or its many manifestations. Thus microelectronic devices, batteries, fuel cells, light-emitting diodes, water electrolyzers, and solar cells all crucially depend on electron transfer for their function.
Effects of substrate misorientation on the properties of (Al, Ga)As grown by molecular beam epitaxy (1985)

(Al,Ga)As layers have rough surface morphologies when deposited under certain growth conditions in molecular beam epitaxy (MBE). This leads to poor interfaces between GaAs and (Al,Ga)As and degraded performance in heterojunction devices. We have observed that by misorienting the substrate slightly from (100), in a manner specific to the growth conditions, smooth (Al,Ga)As layers can be grown at 675 °C for an Al mole fraction of 0.15. Similar conditions for nominal (100) result in a rough, textured morphology. The results suggest that the roughness is due to an energetic instability at the growth surface with respect to the formation of features such as terraces and hillocks. To our knowledge, this is the first reported experimental verification of singular instabilities in (Al,Ga)As grown by MBE. Smooth layers obtained by using an optimal misorientation of 2° 45′ from (100) towards (111)A also exhibit superior optical properties as determined from low-temperature photoluminescence measurements. These findings may have major implications for the performance of heterojunction device structures grown by MBE.
Underwater acoustics education at the University of Texas at Austin (2014)

The University of Texas at Austin has supported education and research in acoustics since the 1930s. The Cockrell School of Engineering currently offers a wide range of graduate courses and two undergraduate courses in acoustics, not counting the many courses in hearing, speech, seismology, and other areas of acoustics at the university. An important adjunct to the academic program in acoustics has been the Applied Research Laboratories (ARL). Spun off in 1945 from the WW II Harvard Underwater Sound Laboratory (1941–1949) and founded as the Defense Research Laboratory, ARL is one of five University Affiliated Research Centers formally recognized by the US Navy for their prominence in underwater acoustics research and development. ARL is an integral part of UT Austin, and this symbiotic combination of graduate and undergraduate courses, and laboratory and field work, provides one of the leading underwater acoustics education programs in the nation. In this talk, the underwater acoustics education program will be described with special emphasis on the underwater acoustics course and its place in the larger acoustics program. Statistics on education, funding, and placement of graduate students in the program will also be presented.
Development of a T‐cell receptor mimic antibody targeting a novel Wilms tumor 1‐derived peptide and analysis of its specificity (2020)

Wilms tumor 1 (WT1) is an intracellular tumor-associated antigen that remains inaccessible to antibodies. Recently, T-cell receptor (TCR) mimic antibodies (TCRm-Abs), which recognize peptides loaded on human leukocyte antigen (HLA) with higher specificity and affinity than TCR, have been developed as a new antibody class that can target intracellular antigens. To expand the therapeutic targets in tumors with WT1, we developed TCRm-Abs targeting a novel HLA-A*02:01-restricted peptide, WT1C (ALLPAVPSL), and validated their specificity using multiple techniques. Screening of these antibodies by ELISA with a panel of peptide/HLA complexes and by glycine scanning of peptide-pulsed T2 cells identified one specific clone, #25-8. Despite the low risk for eliciting broad cross-reactivity of this TCRm-Ab, analysis of a panel of cell lines, in conjunction with exogenous expression of either or both the HLA-A*02:01 and WT1 genes in HeLa cells, revealed that #25-8 reacts with WT1C but also with unknown peptides in the context of HLA-A*02:01. This potentially dangerous cross-reactivity was confirmed through analysis using chimeric antigen receptor T-cells carrying the single-chain variable fragment of #25-8, which targets WT1-negative HeLa/A02 cells. To determine the cross-reactive profiles of #25-8, we applied the PresentER antigen presentation platform with the #25-8-recognition motif, which enables the identification of potential off-target peptides expressed in the human proteome. Our results demonstrate the potential of TCRm-Abs to target a variety of peptides in the context of HLA but also depict the need for systematic validation to identify the cross-reactive peptides for the prediction of off-target toxicity in future clinical translation.
Characterization of Biocompatible Lipid-Based Vesicles Contained with Medicinal Herb Extracts (2018)

In order to increase the medicinal herbs efficiency of drug delivery, vesicles contained with medicinal herbs were prepared by phosphatidylcholines and surface active agent. Vesicles loaded with medicinal herbs were characterized by UV-spectroscopy, Zetasizer. The antioxidant activity of vesicles was measured by DPPH assay and ABTS radical scavenging assays. Also, an analysis was conducted to determine the effects of anti-inflammatory of vesicles contained medicinal herbs. In addition, the whitening effects of vesicles contained medicinal herbs extract were studied via tyrosinase inhibition assay. The results of vesicles were as follows. Vesicles appeared an average diameter of approximatively 164-599 nm. All studied vesicles contained with medicinal herbs showed antioxidant, anti-inflammatory and whitening effects in a dose-dependent manner. Therefore, this experiment achieves its purpose of synthesizing of vesicles. In conclusion, we recommended that the vesicles loaded with medicinal herbs have ability for anti-aging materials. Specifically, it will apply to cosmetic ingredients.
Antigen-Capture ELISA for Rapid Diagnosis of Avian Influenza Virus in Commercial Turkey Flocks (1993)

438 Brief communicationsenzyme-linked immunosorbent assays. J Clin Microbiol 30:28. Tsunemitsu H, Saif LJ, Jiang B, et al.:1991, Isolation, char- 2129-2 134. acterization and serial propagation of a bovine group C rotavirus27. Tsunemitsu H, Jiang B, Yamashita Y, et al.:1992, Evidencein a monkey cell line (MA104). J Clin Microbiol 29:2609-2613.for serologic diversity within group C rotaviruses. J Clin Mi-crobiol 30:3009-3012.J Vet Diagn Invest 5:438-440 (1993)
An improved genome of the model marine alga Ostreococcus tauri unfolds by assessing Illumina de novo assemblies (2014)

High coverage (>80 fold) paired-end Illumina sequencing enables a high quality 95% complete genome assembly of a compact ~13 Mb haploid eukaryote. This genome sequence has remained stable for 6000 generations of lab culture.
Improved Net Protein Balance, Lean Mass, and Gene Expression Changes With Oxandrolone Treatment in the Severely Burned (2003)

Objective To determine the effects of the anabolic agent oxandrolone on muscle protein and gene expression in severely burned children. Summary Background Data The authors previously showed that oxandrolone increased net muscle protein synthesis in emaciated burned patients receiving delayed treatment for severe burns. They hypothesized that similar effects would be seen in those treated early after burn. Methods Thirty-two severely burned children were enrolled in a prospective randomized trial. Subjects underwent studies to assess leg protein net balance 5 days after the first excision and grafting procedure. Immediately after these studies, treatment with placebo (n = 18) or 0.1 mg/kg oxandrolone (n = 14) twice a day was started. One week after this, another net balance study was performed in each subject. Body weights and total body potassium counting were used to determine body compositional changes. Muscle biopsies were taken 1 week after treatment in oxandrolone subjects to examine gene expression changes with gene array (12,600 genes). Results Protein net balance did not change in the placebo group, while oxandrolone-treated subjects had a significant improvement. Body weights and fat free mass significantly decreased in the placebo group, while no changes were found in the oxandrolone-treated subjects. Expression changes were seen in 14 genes in the oxandrolone group compared to placebo. Some of these included myosin light chain (+2.7-fold change), tubulin (+2.3), calmodulin (−2.3), and protein phosphatase I inhibitor (−2.8). Conclusions Oxandrolone improves protein net balance and lean mass in the severely burned. These changes are associated with increased gene expression for functional muscle proteins.
Biomaterial Mesh Seeded with Vascular Remnants from a Quail Embryo Has a Significant and Fast Vascular Templating Effect on Host Implant Tissue (2003)

Seeding biomaterial implants with vascular remnants has the potential to facilitate host vessel ingrowth via a vascular templating effect. Vessels from quail embryo were grown into a polyurethane fibroporous mesh and the samples were frozen-thawed and then implanted in rat subcutaneous dorsum. Results show that the process of revascularization, using the quail vessel remnants, occurred over the first 3 days after implantation and resulted in functional vessels. Rat endothelial cells were found in the quail templates on day 1. On day 2 the endothelial cells formed a confluent layer and started producing laminin. By this time approximately 70% of the rat vessel tissue in the implant had grown into quail vascular remnants, indicating that the quail vessels were extensively used as templates for host vessel ingrowth. Laminin production was increased and collagen production started by day 3, at which time the vessels were functional in that rat blood flowed through them. At 2 weeks host vessel density was approximately twice that of control samples; thus the implant substantially enhanced the size of the vascular network. For meshes that additionally received vascular endothelial growth factor (VEGF) seeding before implantation, vessel density at 2 weeks was enhanced over samples with quail embryo alone. However, the quail was found to have the greatest angiogenic effect above any of the implant components-quail, VEGF, and collagen. Tissue engineering of vessel templates may thus be a realistic solution to effective fast vascularization of biomaterials.
Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion (2011)

Myocardial ischemic disease is the major cause of death worldwide. After myocardial infarction, reperfusion of infracted heart has been an important objective of strategies to improve outcomes. However, cardiac ischemia/reperfusion (I/R) is characterized by inflammation, arrhythmias, cardiomyocyte damage, and, at the cellular level, disturbance in Ca(2+) and redox homeostasis. In this study, we sought to determine how acute inflammatory response contributes to reperfusion injury and Ca(2+) homeostasis disturbance after acute ischemia. Using a rat model of I/R, we show that circulating levels of TNF-α and cardiac caspase-8 activity were increased within 6 h of reperfusion, leading to myocardial nitric oxide and mitochondrial ROS production. At 1 and 15 d after reperfusion, caspase-8 activation resulted in S-nitrosylation of the RyR2 and depletion of calstabin2 from the RyR2 complex, resulting in diastolic sarcoplasmic reticulum (SR) Ca(2+) leak. Pharmacological inhibition of caspase-8 before reperfusion with Q-LETD-OPh or prevention of calstabin2 depletion from the RyR2 complex with the Ca(2+) channel stabilizer S107 ("rycal") inhibited the SR Ca(2+) leak, reduced ventricular arrhythmias, infarct size, and left ventricular remodeling after 15 d of reperfusion. TNF-α-induced caspase-8 activation leads to leaky RyR2 channels that contribute to myocardial remodeling after I/R. Thus, early prevention of SR Ca(2+) leak trough normalization of RyR2 function is cardioprotective.
The Emerging Role of Robotics in Home Health Care (2012)

The demand for health care continues to exceed the supply of affordable, accessible care due in large part to the rapidly aging baby boomer population. The advancing field of robotics can provide an effective solution to this problem. This study aimed to develop a set of user requirements for a personal home health care robot. To generate these requirements, we conducted nine interviews with robotics professionals and three different focus groups with current and future caregivers and the elderly. Using this data we identified prominent and desired functionalities of robots, as well as what may influence their acceptance into the home setting. Our findings indicate that monitoring robots have the biggest acceptance potential among elderly and caregivers.
Bit-slice logic interleaving for spatial multi-bit soft-error tolerance (2010)

Semiconductor devices are becoming more susceptible to single event upsets (SEUs) as device dimensions, operating voltages and frequencies are scaled. The majority of architecture-, logic- and circuit-level techniques that have been developed to address SEUs in logic assume a single-point fault model. This will soon be insufficient as the occurrence of spatial multi-bit errors is becoming prevalent in highly scaled devices. In this paper, we explore this new fault model and evaluate the effectiveness of conventional fault tolerance techniques to mitigate such faults. We also extend the idea of bit interleaving in memory to logic bit slices and explore its utility as an approach to spatial multi-bit error mitigation in logic. We present a comparison of these techniques using a case study of a Brent-Kung adder at a 90-nm process.
Experimental and Modeling Study of the Transport of Chromium Acetate Solutions Through Carbonate Rocks (2010)

Summary Gelled polymer systems are applied to oil reservoirs to reduce water production and to increase sweep efficiencies in recovery processes. A common system consists of hydrolyzed polyacrylamide with a chromium (III) crosslinker. Transport of these chemicals through the reservoir rock is essential for a successful treatment. In carbonate reservoirs, dissolution of the carbonate raises the pH of the gelant to levels where chromium precipitates, robbing the gelant of crosslinker. The transport of chromium acetate solutions through dolomite rock material was studied by injecting various solutions through short cores and measuring Cr, Mg, and Ca concentrations and pH in the effluent. Chromium retention in the cores caused by precipitation was a rate-controlled process. A mathematical model was developed that described convection, dispersion, kinetic reactions of carbonate dissolution and chromium precipitation, and chemical equilibrium for reactions between aqueous components. Experimental data from this work and taken from literature were simulated by the model. One rate equation with one set of parameters described the steady-state values of chromium concentration exiting the cores after the breakthrough of the injected solutions.
Ionization potentials of CaF and BaF (1994)

Although the alkaline earth–monohalide compounds, MX, have been extensively studied, their ionization potentials to MX+ are only known to within a few tenths of an eV. Using an improved electron impact ionization potential measurement to assist in arranging spectroscopic vibronic band origins into Rydberg series, we report high precision ionization potential measurements for CaF and BaF to be IP(CaF)=5.8270±0.0006 eV and IP(BaF)=4.8034±0.0004 eV. The synergism between the electron impact method and the spectroscopic method is detailed, and the minimum accuracy required of the electron impact data is assessed.
Hematologic Reactions to Diazoxide (1967)

One case of neutropenia and one case of thrombocytopenia were seen in patients receiving diazoxide for hypoglycemia.
ChemInform Abstract: HIGH‐TEMPERATURE ORGANIC SYNTHESIS. XVIII. REACTION OF HYDROGEN SULFIDE WITH α‐ OR β‐BROMOSTYRENE (1982)

Abstract Die thermische Kondensation von α‐ bzw. β‐Bromstyrol (Ia) bzw. (Ib) mit H 2 S bei 145 bis 180°C liefert als Hauptprodukt ein und dieselbe Verbindung, 2,4‐Diphenylthiophen (II).