gebhart/patrepeval huggingface dataset:
Control of Flap Vortices (2005)

A wind tunnel investigation was carried out on a semi-span wing model to assess the feasibility of controlling vortices emanating from outboard flaps and tip-flaps by actively varying the degree of boundary layer separation. Separation was varied by means of perturbations produced from segmented zero-efflux oscillatory blowing slots, while estimates of span loadings and vortex sheet strengths were obtained by integrating wing surface pressures. These estimates were used as input to inviscid rollup relations as a means of predicting changes to the vortex characteristics resulting from the perturbations. Surveys of flow in the wake of the outboard and tip-flaps were made using a seven-hole probe, from which the vortex characteristics were directly deduced. Varying the degree of separation had a marked effect on vortex location, strength, tangential velocity, axial velocity and size for both outboard and tip-flaps. Qualitative changes in vortex characteristics were well predicted by the inviscid rollup relations, while the failure to account for viscosity was presumed to be the main reason for observed discrepancies. Introducing perturbations near the outboard flap-edges or on the tip-flap exerted significant control over vortices while producing negligible lift excursions.
Abstract 1134: Analysis of the tumor supressor role of BRG1 in lung cancer (2010)

Abstract The BRG1 protein features a bromodomain and helicase/ATPase activity and is a central component of the SWI/SNF chromatin remodeling complex. At present, the tumor suppressor role of the BRG1 gene, also called SMARCA4, is strongly supported by several genetic and functional observations. First of all, somatic and homozygous genetic inactivation of BRG1 has been observed in a variety of cancer cell lines and studies in lung cancer cells have estimated the frequency of BRG1 inactivation in about thirty per cent of this tumor type. Here we have cloned two BRG1 mutations, lacking the ATPase domain, found in lung cancer cell lines. One of these is a missense change in a highly conserved aminoacid within the ATPase domain (W764R) identified in the NCI-H2126 cell line while the other is an in-frame deletion (E668-Q758 del) identified in the NCI-H1703 cell line. We have studied the capability of these mutations to affect the biological function of BRG1 and compared the efficiency of the wild type BRG1 and that of the two mutants in reducing cell growth in cancer cells. To determine the effect of these mutations on the activity of BRG1 we took advantage of a transcription reporter assay in the human lung carcinoma cell line (NCI-H1299) that lacks wild type BRG1 due to a homozygous mutation. In this system, the simultaneous transfection of the BRG1 constructs and a construct carrying the MMTV-Luciferase reporter plasmid and a GR (glucocorticoid) expression plasmid allows the determination of the contribution of BRG1 to the hormone-dependent regulation of MMTV transcription. Transfection of H1299 cells with these constructs resulted in an eightfold increase of MMTV transcription in the presence of hormone when the cells were transfected with the wild type BRG1 as compared as to the cells transfected with either the mutants or the empty vectors. In addition, we observed that overexpression of wild type BRG1, but not the mutant proteins, in several lung cancer cell lines lead to cell growth suppression. Thus, our present data support an important role of BRG1 tumor suppressor gene in cancer development. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1134.
IN-PLACE DENSIFICATION OF HOT MIX ASPHALT AND VERIFICATION OF SUPERPAVE N(DESIGN) (2002)

The objective of this study was to verify the accuracy of the existing gyration table for the Superpave gyratory compactor. The verification includes data from two major research efforts, an evaluation of 40 field projects and the evaluation of 46 test sections of an accelerated loading test track at the National Center for Asphalt Technology. The results indicate that modified binders reduce the rate of pavement densification. The data appears to validate the currently specified gyration levels for low design traffic levels. Significant differences were found between the compactive efforts of different brands of Superpave gyratory compactors. These differences may be attributed to different internal angles applied to the samples.
Mode of Action of a Silkworm Nuclease and an Analysis of Oligonucleotide (1968)

(1) Oligonucleotideの塩基順列決定法として,家蚕消化液ヌクレアーゼの使用を考え,次のモデル実験を行なった.まず,RNase-IによるRNA分解物より,penta-からheptanucleotideを調製し,各々をモデルの基質として,このヌクレアーゼを作用させた,続いて再分解物は,7M尿素DEAE-セルロースカラムにより分離し,脱塩後,アルカリ分解,ペーパークロマトグラフィーにより同定した.この結果,どのoligonucleotideの再分解物も,7M尿素DEAE-セルロースカラム(pH7.5)で,燐酸基による陰電荷順に6つのピークに分かれた.(-1)価に相当するピークはNpNであり,(-2)価のピークは少量のpNを含むが,大部分はNpNpNであり,いずれも5'末端に由来するfragmentである.そして,これらを重ね合せることにより,5'末端から3個までのヌクレオチド順列を確実に決めることができる.一方,(-5)価,(-6)価のピークはそれぞれ3'末端から生じたpNpNpとpNpNpNpであり,やはり同様に3'末端から3個までのヌクレオチドを決定することができる.また,(-3)価はpNpN,(-4)価はpNpとpNpNpNであり,このうちpNp以外は,元の基質の的部鎖に由来するものであり,アルカリ分解するか,このまま分解せずに分析することにより内部の塩基順列の確認,あるいは高級oligonucleotideの分析に役立つ.そして本法は単にoligonucleotideの分析だけでなく,5'末端に燐酸基を持たない高分子の核酸であれば,5'末端から3個までのヌクレオチド順列決定が可能である. (2)この酵素はpentanucleotideを,最初次のように分解した NpNpNpNpNp_??_NpN+pNpNpNp_??_NpNpN+pNpNp
ChemInform Abstract: Stereocontrolled Preparation of a Nonpeptidal (‐)‐Spirobicyclic NK‐1 Receptor Antagonist. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of DAT1/LIM2--interacting proteins by yeast two--hybrid screening (2005)

Objective To understand the functions of a novel gene, dopamine-associated transcription factor (DAT1). Methods The bait plasmid pLexA-LIM2 was constructed and used to screen the human fetal brain cDNA expressing library using yeast two-hybrid. The interaction between LIM2 and positive clones were verified by yeast mating. Results Three proteins were isolated as interacting proteins of DAT1/LIM2. Yeast mating proved that LIM2 of DAT1 could interact with the three proteins in yeast. Conclusion Calcium and integrin binding protein (CIB), similar to Down syndrome critical region gene 2 (DSCR2) and HSPC170 can interact with DAT1/LIM2 in yeast.
THE CHEMICAL INVESTIGATION OF SPOILED MEAT (1919)

The investigations here described are part of a general study of the problems arising in connection with food poisoning.While the cause of such poisonings is not definitely known, it is often associated with bacteria in spoiling food.The symptoms of poisoning are probably due either to toxins produced in the course of the metabolism of the organisms, or to an infection,of the intestinal tract.Whatever may be the exact relation of bacteria found in spoiling food to the illness caused by its ingestion, it would .bedesirable to develop a chemical test by means of which the early stages of spoilage could be detected.This was one of the objects of the present study.Experimentation was limited to spoiled meat, this being the food most frequently suspected of causing poisoning.Also, the experiments were conducted for the most part on samples inoculated with organisms isolated from meat thought to be responsible for actual cases of poisoning.The general method employed was to study the chemical changes taking place in certain components of the meat as a result of the action of the selected organism.The components thus investigated in the meat under observation were: (1) total nitrogen, (2) non-protein nitrogen, (3) ammonia nitrogen, (4) total creatinine nitrogen (creatine plus creatinine), (5) purine nitrogen.Previous investigators studied the changes in meat in cold storage at temperatures below and above freezing.lAs a rule, the chemical constituents determined differed from those determined in this investigation.
Investigation of surface wave modes on ungrounded electrically thick ceramic alumina substrate at 60 GHz (2016)

Propagation of surface waves modes on ungrounded dielectric slab of ceramic alumina with ε <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</inf> = 9.8 and 635 μm of electrically thick height at 60 GHz is explored. An approximate graphical technique is implemented to determine the unknown propagation constants k <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> and α, to achieve a solution for Helmholtz wave equations, for each TE and TM modes. It also indeed provides a physical insight of existing no. of modes and their dependence on permittivity and height of substrate. Cut-off frequency for all propagating modes is calculated and dispersion graph with propagation constant is plotted. A CPW fed monopole antenna, designed and fabricated at 60 GHz, is found to be affected by the presence of surface wave modes on its radiation characteristics. A tilt of 40° is found in E-plane radiation pattern which certainly evidence the presence of surface wave modes at 60 GHz.
Herpes Simplex Virus: Manipulating DNA Damage Response Pathways (2012)

During infection, cellular DNA damage response (DDR) factors that are beneficial to HSV are recruited while others are degraded or inactivated. For instance, the non‐homologous end joining pathway (NHEJ) is inactivated by ICP0‐mediated degradation of DNA‐PK. Furthermore, we have published that ATR phosphorylation of downstream targets is suppressed during viral infection. Using cell‐based assays we have now shown that single strand annealing (SSA) is stimulated in HSV‐1‐infected cells, while homologous recombination (HR) and classical and alternative NHEJ are not. Interestingly, HSV encodes an exonuclease (UL12) and a single strand annealing protein (ICP8) that together mediate strand exchange in vitro . UL12 and ICP8 are reminiscent of the two subunit “recombinase” of bacteriophage lambda red alpha/beta proteins. Using the cell based assays we find that UL12 can specifically stimulate SSA; whereas, a catalytically dead UL12 protein cannot. In addition, interactions between UL12, ICP8 and cellular DDR proteins including MRN, MSH2 and MSH6 suggest that the HSV “recombinase” may interact with host DDR factors to effect pathway choice and promote appropriate recombination‐dependent DNA synthesis. Concatemer formation is an essential step for the generation of progeny virus, and we are interested in whether SSA is the preferred cellular pathway utilized by HSV during infection to create concatemers. This work was supported by NIH R01‐ AI37549, NIH RO1‐AI21747 and Connecticut stem cell research grant 09‐SCA‐UCHC‐34.
Basic concepts of the crystallization from aqueous solutions: The example of aluminum oxy(hydroxi)des and aluminosilicates (2011)

This overview features the chemical background on condensation phenomena of the aluminum cation in aqueous solution. The formation of polycationic molecular clusters and nanosized solid phases of aluminum oxy(hydroxi)des is interpreted with illustrative mechanisms, building a bridge between solution chemistry and solid-state chemistry. The formation of the main structural types of aluminosilicates (zeolites, clays, imogolite) is also illustrated through the aqueous chemistry of aluminum and silicates.
Differential Regulation of Testicular Transferrin and Androgen-Binding Protein Secretion in Primary Cultures of Rat Sertoli Cells* (1986)

Specific RIAs for rat transferrin (rTF) and androgen-binding protein (rABP) were used to determine whether the secretion of these proteins was coordinately regulated in the Sertoli cell under a variety of conditions. Sertoli cell-enriched primary cultures were prepared from the testes of 20-day-old rats, and rTF and rABP were assayed in medium from the same culture. There was a strong effect of cell density on both rABP and rTF secretion per cell, with increased secretion per cell at high densities. Human TF (hTF), FeSO4, and desferrioxamine had little or no effect on rTF secretion. The age of the animal at the time of preparation of cells for culture had a strong effect on the pattern of rTF and rABP secretion in vitro; however, the effects of animal age, time in culture, and medium supplementation differed for the two proteins. In cultures prepared from 20-day-old animals, insulin, epidermal growth factor, and testosterone stimulated both rTF and rABP secretion, although to different extents. Retinoic acid was required for the stimulation and maintenance of rTF secretion, but had no effect on rABP secretion in the presence of insulin, hTF, and epidermal growth factor. Conversely, FSH and isoproterenol stimulated rABP, but not rTF, secretion. These data suggest that the secretion of rABP and rTF by Sertoli cells is under differential control.
An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish (2017)

In terrestrial vertebrates such as birds and mammals, neurotrophin receptor expression is considered fundamental for the specification of distinct somatosensory neuron types where TrkA, TrkB and TrkC specify nociceptors, mechanoceptors and proprioceptors/mechanoceptors, respectively. In turn, Runx transcription factors promote neuronal fate specification by regulating neurotrophin receptor and sensory receptor expression where Runx1 mediates TrkA+ nociceptor diversification while Runx3 promotes a TrkC+ proprioceptive/mechanoceptive fate. Here, we report in zebrafish larvae that orthologs of the neurotrophin receptors in contrast to terrestrial vertebrates mark overlapping and distinct subsets of nociceptors suggesting that TrkA, TrkB and TrkC do not intrinsically promote nociceptor, mechanoceptor and proprioceptor/mechanoceptor neuronal fates, respectively. While we find that zebrafish Runx3 regulates nociceptors in contrast to terrestrial vertebrates, it shares a conserved regulatory mechanism found in terrestrial vertebrate proprioceptors/mechanoceptors in which it promotes TrkC expression and suppresses TrkB expression. We find that Cbfβ, which enhances Runx protein stability and affinity for DNA, serves as an obligate cofactor for Runx in neuronal fate determination. High levels of Runx can compensate for the loss of Cbfβ, indicating that in this context Cbfβ serves solely as a signal amplifier of Runx activity. Our data suggests an alteration/expansion of the neurotrophin receptor code of sensory neurons between larval teleost fish and terrestrial vertebrates, while the essential roles of Runx/Cbfβ in sensory neuron cell fate determination while also expanded are conserved.
The Analysis and Application of Architectural Meteorology for Low Carbon Buildings in Taiwan (2013)

In order to decrease the impacts of climate changes and global warming on the environment, many countries have started the zero carbon or low carbon researches to decrease the production of CO2. The government of Taiwan also follows the trend in conserving energy and decreasing carbon production and develops a “low carbon island” demonstration plan. The energy consumption of a building is closely linked to the climates of its location. Therefore, studying the local climates is the foundation of low carbon building design. However, the meteorological data collected for general purposes do not provide detailed sorting and time selection for building design. Therefore, it is important to create an architectural meteorological database specially for building design. In this research, we created an architectural meteorological database for Liuqiu island, an off-shore island in the “low carbon island” plan of Taiwan. Using this database, the building designer can improve the natural ventilation design of the building to decrease the usage of air conditioning and the goal of low carbon building can be achieved easily.
Defective reactivation of ultraviolet light-irradiated herpesvirus by a Bloom's syndrome fibroblast strain. (1979)

We have used the technique of host cell reactivation of UV-irradiated herpes simplex virus type 1 as a measure of the repair capacity of three Bloom's syndrome skin fibroblast strains. At low multiplicity of infection (less than 6 x 10(-4) plaque-forming unit/cell), reactivation of the virus by the Bloom's syndrome strains was indistinguishable from that by normal strains. Reactivation at higher multiplicities was measured using an infectious centers assay. At 3 plaque-forming units/cell, survival of UV-irradiated herpes simplex virus was higher in all cell strains as a result of the multiplicity reactivation effect. This effect was, however, much smaller in one Bloom's syndrome strain, GM1492, than in either the normal strains or the other Bloom's syndrome fibroblasts. The defect in GM1492 was manifest only at relatively high multiplicates of infection. Thus, at 0.01 plaque-forming unit/cell, the GM1492 strain appeared normal, using the infectious centers assay. Clonal survival of the UV-irradiated GM1492 fibroblasts was also normal. Caffeine at 4 mM had little effect on either virus or cell survival following UV irradiation. The results indicate that the Bloom's syndrome strain GM1492 may be deficient in one of the cellular functions responsible for the multiplicity reactivation effect. These effects include complementation and recombinational events. Alternatively, the GM1492 strain may have a defective UV repair system which becomes saturated at high levels of damage.
A two-stage sequential demodulator for the Gosset lattice (1989)

A construction of the Gosset lattice is considered that has practical advantages over other constructions of the same lattice. Codes derived from this construction have been shown to exhibit a null at DC in their baseband spectrum. A two-stage approach to the demodulation of this construction of the Gosset lattice is discussed. This demodulator consists of an initial stage which may declare erasures and a secondary stage designed to correct erasures. A study of erasure events is made and then used to reduce the number of steps in the second-stage correction algorithm. While the overall demodulator is somewhat more complex than a straight forward maximum-likelihood demodulator designed for this construction, the present structure has the advantage of greater speed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Telemetry Bandwidth Selection for Infrared Surveillance Sensors, (1983)

Abstract : Information theory, modelling and computer simulation are combined in this study to minimize the telemetry/recorder bandwidth requirements for IR sensors being developed by AFGL. The study included development and documentation of a computer code for optimizing the design of choppers, filters and electronics for IR radiometers. (Author)
Living Cyclopolymerization of 1,6-Heptadiyne Derivatives Using Well-Defined Alkylidene Complexes: Polymerization Mechanism, Polymer Structure, and Polymer Properties (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiving Cyclopolymerization of 1,6-Heptadiyne Derivatives Using Well-Defined Alkylidene Complexes: Polymerization Mechanism, Polymer Structure, and Polymer PropertiesHarold H. Fox, Michael O. Wolf, Richard O'Dell, Beatrice L. Lin, Richard R. Schrock, and Mark S. WrightonCite this: J. Am. Chem. Soc. 1994, 116, 7, 2827–2843Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://doi.org/10.1021/ja00086a016RIGHTS & PERMISSIONSArticle Views1234Altmetric-Citations196LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
ChemInform Abstract: Laser Flash Photolysis of Chlorine Dioxide: Formation and Ultaviolet Absorption Spectrum of Cl2O3. (1989)

Abstract The kinetic and spectroscopic results obtained for the photodecomposition of ClO 2 in CFCl 3 solution following nanosecond pulsed 337.1 nm irradiation show that the instantaneous photochemical bleaching is followed by a slower bleaching which obeys pseudo‐first‐order kinetics and leads to the formation of a long‐lived transient species having an absorption spectrum with λmax ∼280 nm.
Prediction of Aortoiliac Stent-Graft Length: Comparison of Measurement Methods (2001)

The shortest aortoiliac path length maintaining at least one radius distance from the vessel wall most accurately enabled stent-graft length prediction for 31 AneuRx and two Excluder stent-grafts.
Microscale elastic-strain determination by backscatter Kikuchi diffraction in the scanning electron microscope (1993)

It is shown that backscatter Kikuchi diffraction in the scanning electron microscope can be used for the determination of elastic strain with μm resolution. From the shift of Kikuchi bands in backscatter Kikuchi diffraction patterns of epitaxial Si1−xGex layers on Si(100) the perpendicular elastic strain was determined to be 2.5% for x=0.34 and at 1.0% for x=0.16 with an accuracy of about 0.1%. The values found on a μm scale were in good agreement with high-resolution x-ray diffraction measurements averaging over mm distances.
The Scutellaria Flavone, Oroxylin A, Improves Attention-Deficit/Hyperactivity Disorder Related Behaviors in Spontaneously Hypertensive Rats (2008)

Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean medicine. In this study, we investigated the psychopharmacological activities of oroxylin A using the open field, rota-rod, balanced wire and plus-maze tests in Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto Rats (WKY). Oroxylin A reduced hyperactivity in SHR (ADHD animal model) although it tended to increase locomotor activity in WKY. Methylphenidate did not reduce hyperactivity. Oroxylin A alleviated impulsive behaviors such as rearing, the percentage of moving time to the central area and the tendency to move into an unstable condition (open area in elevated plus-maze). Methylphenidate also reduced the percentage of staying time in the central area and the tendency to move into an unstable condition. Both oroxylin A and methylphenidate enhanced motor attention in SHR and WKY. Oroxylin A antagonized the muscimol (<TEX>$GABA_A$</TEX> receptor agonist)-induced <TEX>$Cl^-$</TEX>current and its action was similar to that of bicuculline (<TEX>$GABA_A$</TEX> receptor antagonist). The effects of oroxylin A may be caused by the antagonism at the <TEX>$GABA_A$</TEX> receptor. Thus, oroxylin A may be a candidate of drug for treatment of ADHD.