gebhart/patrepeval huggingface dataset:
The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesis (1999)

There is growing evidence that implicates a role for Sonic hedgehog (SHH) in morphogenesis of the craniofacial complex. Mutations in human and murine SHH cause midline patterning defects that are manifested in the head as holoprosencephaly and cyclopia. In addition, teratogens such as jervine, which inhibit the response of tissues to SHH, also produce cyclopia. Thus, the loss of SHH signaling during early stages of neural plate patterning has a profound influence of craniofacial morphogenesis. However, the severity of these defects precludes analyses of SHH function during later stages of craniofacial development. We have used an embryonic chick system to study the role of SHH during these later stages of craniofacial development. Using a combination of surgical and molecular experiments, we show here that SHH is essential for morphogenesis of the frontonasal and maxillary processes (FNP and MXPs), which give rise to the mid- and upper face. Transient loss of SHH signaling in the embryonic face inhibits growth of the primordia and results in defects analogous to hypotelorism and cleft lip/palate, characteristics of the mild forms of holoprosencephaly. In contrast, excess SHH leads to a mediolateral widening of the FNP and a widening between the eyes, a condition known as hypertelorism. In severe cases, this widening is accompanied by facial duplications. Collectively, these experiments demonstrate that SHH has multiple and profound effects on the entire spectrum of craniofacial development, and perturbations in SHH signaling are likely to underlie a number of human craniofacial anomalies.
ChemInform Abstract: C‐2‐Functionalized N6‐Cyclosubstituted Adenosines: Highly Selective Agonists for the Adenosine A1 Receptor. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development of Map-building and Pose Estimation Component and Evaluation in Actual Environment (2014)

レーザ距離センサによる幾何形状データのマッチングに基づく地図作成・位置同定技術は，産業分野においては，特に無人搬送車の走行制御や物品の所在管理などへの応用が期待されている．しかし，これらの技術は，システムへの組込みが容易な形での提供されていないことなどから，産業応用はあまり進んでいない状況にある．これを踏まえ，筆者らは，システムへの組込みの簡単化を目的として，地図作成・位置同定用コンポーネントの開発を行った．同コンポーネントは，環境変化時の位置同定誤りの原因となる，レーザ距離センサ周辺の計測点の重みを減らすマッチング，また，幾何的特徴を保持しながら低解像度化した地図によるCoarse to Fineベースの高速処理などを特徴とする．本稿では，実用化に向けて生じた課題と対処，想定利用分野に合わせて策定した運用フローなどについて述べ，また，製造現場への適用を通してコンポーネントの有効性を示す．
Transcriptional Regulation of the MN/CA 9 Gene Coding for the Tumor-associated Carbonic Anhydrase IX (1999)

The MN/CA 9 (MN) gene encodes a tumor-associated isoenzyme of the carbonic anhydrase family. Functional characterization of the 3. 5-kilobase pair MN 5' upstream region by deletion analysis led to the identification of the -173 to +31 fragment as the MN promoter. In vitro DNase I footprinting revealed the presence of five protected regions (PRs) within the MN promoter. Detailed deletion analysis of the promoter identified PR1 and PR2 (numbered from the transcription start) as the most critical for transcriptional activity. PR4 negatively affected transcription, since its deletion led to increased promoter activity and was confirmed to function as a promoter-, position-, and orientation-independent silencer element. Mutational analysis indicated that the direct repeat AGGGCacAGGGC is required for efficient repressor binding. Two components of the repressor complex (35 and 42 kDa) were found to be in direct contact with PR4 by UV cross-linking. Increased cell density, known to induce MN expression, did not affect levels of PR4 binding in HeLa cells. Significantly reduced repressor level seems to be responsible for MN up-regulation in the case of tumorigenic CGL3 as compared with nontumorigenic CGL1 HeLa x normal fibroblast hybrid cells.
Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12. (1999)

The antitumor activity of recombinant murine interleukin-12 (rIL-12) is documented by a large set of data from numerous mouse models. Because the cellular and molecular mechanisms by which rIL-12 impairs tumor growth are still not fully defined, we compared the effects of local and systemic rIL-12 administration in mice harboring an invasive 7-day-old moderately differentiated and spontaneously metastasizing mammary adenocarcinoma (TSA). Whereas the immune events elicited via the two routes of rIL-12 administration seem to be the same, systemic rIL-12 is markedly more effective; tumor destruction is dependent on a prompt antitumor response resulting from the cooperation of several subsets of reactive cells. The reactions that seem to play a key role are: (a) indirect inhibition of angiogenesis by secondary cytokines (mainly IFN-gamma) and third-level chemokines (inducible protein 10 and monokine induced by IFN-gamma); (b) systemic activation of leukocyte subsets capable of producing proinflammatory cytokines, CTLs, and antitumor antibodies; and (c) destruction of tumor vessels by polymorphonuclear cells. The markedly higher efficacy of systemic rIL-12 seems to rest on its ability to recruit these systemic reactions more quickly and efficiently than local rIL-12.
Etude d'un algorithme itératif d'annulation de repliement spectral lors d'une conversion A/N parallèle (2002)

International audience
An Internal Calibration Approach of Multi-Channel SAR Sensors (2017)

Calibration methods of state-of-the-art spaceborne SAR are reviewed to suggest calibration strategies for future SAR systems. These systems will utilize digital beamforming, which poses new challenges for the calibration, as the increased complexity of multi-channel SAR does not allow for the extrapolation of current calibration techniques. Further, real-time error measurement and correction is unavoidable, which requires reconsidering current calibration approaches. One the other hand, the digital hardware already present in multi-channel SAR systems, offer opportunities for the calibration such as on-board error correction and digital calibration. This paper presents a calibration scheme suitable for multi-channel digital beam-forming SAR. The main characteristics of the suggested calibration concept is, that, it avoids the typical interruption of SAR operation when injecting the calibration signal --which would cause lost imaging pulses or a reduction in swath--, and that it allows for on-board channel correction. Internal calibration concepts do not measure errors outside the calibration signal path, such as the antenna, which thus cannot be corrected. These deficiencies are overcome by using a data driven calibration, meaning that the channel errors are extracted from the (raw) receive SAR data.
Enhancement of ischemic wound healing by inducement of local angiogenesis (2010)

Delivery of activated pro-angiogenic monocytes to an ischemic skin flap tended to improve histologic evidence of vascularity without corresponding microscopic or gross evidence of improved flap survival. These results are encouraging regarding the use of monocytes as a potential method of improving vascularization of ischemic tissue.
Corrélation des propriétés mécaniques et micro-structurelles de la peau de souris à partir d'une sollicitation bi-axiale (2017)

International audience
Neuronal Response Clamp (2011)

Responses of individual neurons to ongoing input are highly variable, reflecting complex threshold dynamics. Experimental access to this threshold dynamics is required in order to fully characterize neuronal input-output relationships. The challenge is practically intractable using present day experimental paradigms due to the cumulative, non-linear interactions involved. Here we introduce the Neuronal Response Clamp, a closed-loop technique enabling control over the instantaneous response probability of the neuron. The potential of the technique is demonstrated by showing direct access to threshold dynamics of cortical neuron in vitro using extracellular recording and stimulation, over timescales ranging from seconds to many hours. Moreover, the method allowed us to expose the sensitivity of threshold dynamics to spontaneous input from the network in which the neuron is embedded. The Response-Clamp technique follows the rationale of the voltage-clamp and dynamic-clamp approaches, extending it to the neuron's spiking behavior. The general framework offered here is applicable in the study of other neural systems, beyond the single neuron level.
Mitochondrial DNA Deletion in a Child With Mitochondrial Encephalomyopathy, Growth Hormone Deficiency, and Hypoparathyroidism (2006)

We report an 11-year-old boy with short stature, bilateral ptosis, sensorineural hearing loss, muscle weakness, and endocrine abnormalities. Brain magnetic resonance imaging (MRI) showed a bilateral abnormal signal in the globus pallidus and in the midbrain tegment. Muscle biopsy specimens showed ragged red and cytochrome c oxidase negative fibers, and biochemical analysis of muscle homogenate showed a partial defect of complex I and IV activities of the respiratory chain enzymes. Analysis of mitochondrial DNA by a polymerase chain reaction screening procedure and Southern blot revealed a novel heteroplasmic single mitochondrial DNA deletion of 7.8 kb in different tissues. This deletion was absent in the blood DNA of his mother and brother. This case further expands and confirms the wide clinical spectrum of mitochondrial disorders associated with single large-scale mitochondrial DNA deletions.
Synthesis of Hydroxamic Acids by Activation of Carboxylic Acids with<i>N</i>,<i>N</i>′-Carbonyldiimidazole: Exploring the Efficiency of the Method (2010)

Activation of carboxylic acids with N,N′-carbonyldiimidazole followed by the reaction with anhydrous or aqueous hydroxylamine hydrochloride was demonstrated to be an operationally simple method for the synthesis of hydroxamic acids in good yield and high purity after aqueous workup. The potential by-product, N,O-diacylhydroxylamine, is cleanly transformed to hydroxamic acid in these reaction conditions.
Identification of<i>Dirofilaria immitis</i>Proteins Recognized by Antibodies from Infected Dogs (2014)

The identification of excreted-secreted (ES) proteins of filarial nematodes as potential diagnostic reagents is an important requirement for the development of methods to determine level of infection in the host, especially for human filariae. Dirofilaria immitis, the canine heartworm, is a widespread and important veterinary pathogen and is a useful model for filarial parasites of humans. An analysis of proteins released from adult D. immitis (the secretome) in culture is available. We sought to identify D. immitis ES proteins found in vivo to validate the in vitro secretome and to investigate them as potential diagnostic reagents. Cultures of D. immitis adults obtained from infected dogs were maintained for 72 hr with daily changes of media. Proteins were concentrated from spent media by standard methods and were passed through Protein-A columns containing purified IgG antibodies from heartworm-infected dogs. Following extensive washing, heartworm proteins recognized by the antibodies were eluted from these columns and submitted for analysis by tandem mass spectrometry (MS/MS). As a comparison, somatic proteins from adult D. immitis female parasites and microfilaria were also processed and analyzed by the same protocol. Six, 9, and 12 proteins were identified by MS/MS in the ES, adult female, and microfilaria samples, respectively. The identification of the most abundant parasite proteins present in the serum of infected hosts offers a rational approach to the development of new diagnostic assays that may be applicable across the Filarioidea.
The Security of Confidential Numerical Data in Databases (2002)

Organizations are storing large amounts of data in databases for data mining and other types of analysis. Some of this data is considered confidential and has to be protected from disclosure. When access to individual values of confidential numerical data in the database is prevented, disclosure may occur when a snooper uses linear models to predict individual values of confidential attributes using nonconfidential numerical and categorical attributes. Hence, it is important for the database administrator to have the ability to evaluate security for snoopers using linear models. In this study we provide a methodology based on Canonical Correlation Analysis that is both appropriate and adequate for evaluating security. The methodology can also be used to evaluate the security provided by different security mechanisms such as query restrictions and data perturbation. In situations where the level of security is inadequate, the methodology provided in this study can also be used to select appropriate inference control mechanisms. The application of the methodology is illustrated using a simulated database.
Lévy NMF : un modèle robuste de séparation de sources non-négatives (2017)

International audience
Infrared 45° reflectometry of Li doped ZnO films (2004)

Lithium doped (0–10 at. % Li) ZnO films were grown in the wurtzite structure on sapphire (001) substrates and investigated in the 200–1200 cm−1 frequency range at 300 K by far-infrared reflectivity spectroscopy using polarized oblique (45°) incidence. This technique has enabled us to determine the longitudinal optical phonon frequency E1(LO) at 576 cm−1 of the fundamental lattice vibration at the center of the Brillouin zone, as well as to investigate the LO phonon-plasmon coupling in the low carrier density (N⩽1018 cm−3) ZnO films. The energy shift and halfwidth broadening of the LO phonon band in comparison with the uncoupled mode in high-ohmic ZnO:0.8 at. % Li (ρdc=0.6×106 Ω cm) film have been analyzed to get the concentration and “optical” mobility of charge carriers in the Li doped ZnO films. The results of optical, x-ray diffraction and dc resistivity measurements are discussed.
80-MHz difference-frequency generation of femtosecond pulses in the mid-IR using GaS0.4Se0.6 (2013)

We employ GaS0.4Se0.6 nonlinear crystal for difference-frequency generation between signal and idler of a synchronously pumped femtosecond OPO at 80 MHz achieving continuous tuning from 4 µm (>12 mW) to 12 µm (>0.5 mW).
Polarized electronic sources for future e{sup +}/e{sup {minus}} linear colliders (1997)

Polarized electron beams will play a crucial role in maximizing the physics potential for future e{sup +}/e{sup {minus}} linear colliders. We will review the SLC polarized electron source (PES), present a design for a conventional PES for the Next Linear Collider (NLC), and discuss the physics issues of a polarized RF gun.
Up-regulation of oxytocin receptors in non-pregnant rat myometrium by isoproterenol: effects of steroids (1999)

The objective of the present study was to further elucidate our previous observation that beta2-adrenoceptor activation induces oxytocin receptor (OTR) expression in rat myometrium. We wanted to investigate whether the mechanism behind this effect was under the influence of gonadal steroids. Ovariectomized non-pregnant rats were treated with estrogen, progesterone or a combination of both for 3 days. Some rats were concomitantly treated with isoproterenol. Estrogen treatment increased both OTR mRNA production and maximal binding of [3H]-oxytocin to isolated myometrial plasma membranes, but it did not affect contractility of isolated uterine strips challenged with oxytocin. When the estrogen regimen was combined with isoproterenol treatment, an augmented maximal contractile response (Emax) to oxytocin was observed although no further increase in OTR mRNA and binding was seen. Progesterone treatment did not in itself alter OTR mRNA, OTR binding or Emax. However, OTRs were induced at the level of gene expression when progesterone was supplemented with isoproterenol infusion. Finally, progesterone suppressed the effect of estrogen on OTR mRNA production and binding when the two compounds were administered together. However, when isoproterenol treatment was added this effect was abolished and Emax was enhanced more than that seen following treatment with estrogen alone. These data suggest that beta2-adrenoceptor activation represents an important regulator of OTR expression/function in estrogen- and progesterone-dominated rat myometrium.
Far Infrared Spectroscopy of Sr<sub>1-x</sub>Ba<sub>x</sub>TiO<sub>3</sub>(0.01 ≤ x ≤ 0.2) Ceramics (2007)

We report on lattice dynamics and far infrared dielectric response of Sr 1−x Ba x TiO 3 ceramics with small concentration of Ba (0.01 ≤ x ≤ 0.2). Reflectivity spectra were obtained on cooling down to 5 K by Fourier transform interferometer in the 25–650 cm− 1 frequency range and by coherent-source submillimetre technique in the 30–40 cm− 1 range and fitted by the factorized model of the dielectric function. Fitted permittivity was compared with the dielectric data measured in the 10 2 –10 6 Hz frequency range. Splitting of the soft TO1 phonon into E and A 1 components, indicating the ferroelectric transition, was observed for x ≥ 0.05. In addition to the soft mode dispersion, low-frequency dielectric relaxation was observed in the vicinity of the permittivity maximum, indicating a crossover into order-disorder regime with relaxor ferroelectric features.
Field Investigation on Effect of Disaster Reduction against Tsunami Using Coastal Forestation in Japan (2014)

The 2011 off the pacific coast of Tohoku earthquake caused the extensive damage along the coast of Tohoku area facing the Pacific Ocean with tsunami. Not only Tohoku area facing the Pacific Ocean but also any coastal areas in Japan are under threat of heavy disasters due to earthquakes and tsunamis. It has been clarified that the coastal forestation is effective to reduce the damage due to tsunami by our previous studies on the coast of Sendai plain. In this study, a new index for effectiveness of the forestation against the disaster due to tsunami is deduced from existing data and is extended to other coastal areas in Japan through tsunami height estimated by mathematical simulations by plate tectonics in the central part and southern part of the Pacific side of Japan.
Phase-Diverse Wavefront Sensing (2006)

Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text R. Paxman, "Phase-Diverse Wavefront Sensing," in Frontiers in Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2006), paper FML3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Supine and exercise systolic blood pressure predict cardiovascular death in middle-aged men (2001)

These results are different from the mortality data at 16 years, when the independent predictive effect of supine systolic BP was cancelled out by 6 min exercise systolic BP at 600 kpm/min. Twenty-one years of follow-up of 1999 apparently healthy men disclose independently predictive information on CV death, of both supine systolic BP and 6 min exercise systolic BP taken at an early moderate workload. The influence of maximal exercise systolic BP on CV death is however cancelled out by the two other systolic BPs.
Chemical structures of new piericidins produced by Streptomyces pactum. (1977)

Chemical structures of new piericidins produced by Streptomyces pactum are elucidated on the basis of mass, PMR and CMR spectral analyses. Consequently, these piericidins were shown to be constructed by a combination of variations in each four functionalities and carbon skeletons.
Introduction to the special issue on the applications of ferroelectrics - part I (2007)

The 39 papers in Part I of this special issue focus on the applications of ferroelectrics. The issue seeks to address the current state of the field by providing an overview of the fundamental materials science required to advance the discipline, as well as detailed papers on the applications of ferroelectric materials.
First Results with the Prototype Detectors of the Si/W ECAL (2005)

Measurements on the prototype silicon sensors for use with an electromagnetic calorimeter with tungsten absorber are reported. The prototype sensors are based on a hexagonal geometry that optimally utilizes the space available on 6 inch silicon wafers. The sensors are segmented into approximately 750 5 mm hexagonal pixels, which are connected to a bump-bonding array located at the center of the sensors. We report on those properties of the sensors that are important for linear collider applications including depletion voltage, stray capacitance and series resistance. 1.
Novel Carbon-Based Nanoadsorbents for Water Purification (2014)

With its many interesting physicochemical properties, carbon continues to attract the attention of scientists and engineers alike. Consequently, it is the most cited element in the scientic literature. If you search for “carbon” on the webpage of any scientic journal that publishes reports on materials, the chance that the search will hit the page limit is signicantly high. Therefore, in the context of wastewater treatment, it is not surprising that although the utility of carbon in its allotropic form of charcoal was recognized many years ago, dating back to the prehistoric era, it remains the core material of modern water lters. In recent times, with nanotechnology applied to the many facets of environmental remediation, either in process intensication or product development, several groups are on the forefront of developing novel carbon-based nanoadsorbents for water purication.
The Neural Circuits That Generate Tics in Tourette's Syndrome (2011)

Our findings, taken together, suggest that tics are caused by the combined effects of excessive activity in motor pathways and reduced activation in control portions of cortico-striato-thalamo-cortical circuits.
Detection of human papillomavirus (HPV) DNA in focal epithelial hyperplasia (1989)

Five focal epithelial hyperplasia (FEH) specimens from four patients were examined by Southern blot hybridization analysis to determine the specific human papillomavirus (HPV) types present. The histomorphologic features of these specimens were also evaluated and a broad variety of changes including koilocytes, mitosoid cells, ballooning cells and cells showing individual cell keratinization were noted. FEH lesions from the three patients sharing a familial relationship demonstrated HPV DNA sequences that were either the prototype HPV-13 or a very closely related HPV-13 subtype. These patients also showed similar clinical features. Lesional tissue from the other patient was found to harbor HPV DNA sequences similar to HPV-32. In view of these findings it is suggested that these specific HPV types are associated with the characteristic FEH histomorphology described.
A molecular-dynamics study of lipid bilayers: Effects of the hydrocarbon chain length on permeability (2005)

In this paper, we investigate the effects of the hydrocarbon chain length of lipid molecules on the permeation process of small molecules through lipid bilayers. We perform molecular-dynamics simulations using three kinds of lipid molecules with different chain length: dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, and dipalmiltoylphosphatidylcholine. Free-energy profiles of O2, CO, NO, and water molecules are calculated by means of the cavity insertion Widom method and the probability ratio method. We show that the lipid membrane with longer chains has a larger and wider energy barrier. The local diffusion coefficients of water across the bilayers are also calculated by the force autocorrelation function method and the velocity autocorrelation function method. The local diffusion coefficients in the bilayers are not altered significantly by the chain length. We estimate the permeability coefficients of water across the three membranes according to the solubility-diffusion model; we find that the water permeability decreases modestly with increasing chain length of the lipid molecules.