gebhart/patrepeval huggingface dataset:
Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring (2018)

Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a life‐long disease in which the genes responsible are known, but the pathogenesis of cyst formation and cyst growth are not understood. Cyst growth ultimately leads to end‐stage renal failure in most patients. Analysis of the urinary proteome offers the potential to identify proteins that indicate the presence of cysts (and thus provides diagnosis) as well as the rates of cyst growth (providing prognostic information). Experimental design A scheduled parallel reaction monitoring (sPRM) assay is performed on urine samples from 14 patients and 18 normal controls. For relative quantification, stable isotope‐labeled synthetic peptides are spiked in the urinary protein digests prior to data collection. The data are subsequently normalized to creatinine and protein concentration in the respective urine samples to control for variations in water intake between individuals. Results Out of the 143 urinary proteins targeted for sPRM assay, 69 proteins are observed to be significantly dysregulated in ADPKD. The dysregulated proteins are used to cluster ADPKD patients into those who are more or less similar to normal controls. Conclusions and clinical relevance This study shows that sPRM is a promising approach to rapidly screen large numbers of proteins in urine in order to provide earlier diagnosis and potentially better understand the pathogenesis of ADPKD development and progression.
P001 Interleukin-21 exerts pathogenic and host-protective effects in experimental models of colitis (2013)

Background: Interleukin-21 is a T-cell derived cytokine implicated in the pathogenesis of chronic inflammatory diseases, including IBD. IL-21-receptor (IL-21R) is reported to be expressed on a diverse array of cells, including both haematopoetic and epithelial cells. In T-cells, IL-21 signaling may be a critical regulator of the balance of Th17 and regulatory (Treg) responses. However, the in vivo role of IL-21 in experimental IBD is not well understood. Methods: Using IL-21R-deficient mice, we examined the effects of IL-21 signals in complimentary models of murine IBD, including CD4+CD45RBhi T-cell transfer, Helicobacter hepaticus/anti-IL-10R, and Citrobacter rodentium infection. Results: In the Helicobacter hepaticus/anti-IL-10R model, IL-21 was pathogenic, with reduced Th17 populations and increased FOXP3+ Treg cell accumulation in the mucosa of IL-21R / animals. Similarly, in the T-cell transfer model of disease, IL-21R / T-cells were impaired in their ability to induce disease, associated with a cell-intrinsic requirement for IL-21 to regulate the balance of FOXP3+ Treg and IFN-g+ Th1 cells in the intestine. Further studies implicate a role for IL-21 in driving the expression of T-cell attracting chemokines in both these models, with studies in T-cell transfer suggesting this to be a direct T-cell dependent effect. In contrast, IL-21 was required for host protection in Citrobacter rodentium infection, with IL-21R / mice developing more severe intestinal disease, associated with greater bacterial burdens and systemic dissemination of infection. In this model, mice deficient in IL-21R were unimpaired in their Th17 responses, but developed robust Th1 responses, and an IFN-g driven immunopathology. Conclusions: IL-21 is a critical regulator of intestinal immune responses in models of IBD, exerting context specific pathogenic or host-protective effects. IL-21 may therefore be an important future therapeutic target in IBD, but its pleiotrophic effects must be considered in the development and use of drugs targeting this pathway. P002 Intestinal homeostasis is critically regulated by the transcription factor T-bet N. Powell1 *, E. Stolarczyk1, J. Lo1, J. Canavan1, E. Marks1, T. MacDonald2, G. Lord1. 1King’s College London, Experimental Immunobiology, London, 2Queen Mary University, Immunity and Infectious Diseases, London, United Kingdom
Synthesis and characterization of interpenetrating polymer networks of poly(2,6-dimethyl-1,4-phenylene oxide) and poly(butadiene) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of interpenetrating polymer networks of poly(2,6-dimethyl-1,4-phenylene oxide) and poly(butadiene)Harry L. Frisch and Yaohe HuaCite this: Macromolecules 1989, 22, 1, 91–93Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ma00191a018https://doi.org/10.1021/ma00191a018research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride. (1986)

We have previously reported the cytotoxicity and antitumor activity of bis(diphenylphosphino)ethane (DPPE) and a variety of its transition metal complexes. During studies of the chemistry of a gold complex of this group [(AuCl)2(DPPE)], it was observed that this complex readily underwent ring closure on reaction with DPPE to form the tetrahedral complex [Au(DPPE)2]+. Various counterion forms (e.g., Cl-) of this cation were isolated and were found to exhibit a remarkably high stability in solution. Evaluation of [Au(DPPE)2]Cl in mice bearing i.p. P388 leukemia demonstrated that the compound produced an average of 87% increase in life span at its maximally tolerated dose (2-3 mumol/kg/day for 5 days). Activity was also seen in i.p. M5076 reticulum cell sarcoma (60% increase in life span) and s.c. mammary adenocarcinoma 16/c. Modest activity was evident in i.p. B16 melanoma and L1210 leukemia. A subline of P388 leukemia resistant to cisplatin was not cross-resistant to [Au(DPPE)2]Cl. In addition, combination therapy of [Au(DPPE)2]Cl and cisplatin against i.p. P388 demonstrated an advantage over single-agent therapy. In vitro studies of [Au(DPPE)2]Cl showed that the compound: is cytotoxic to tumor cell lines; is only minimally inhibited in its cytotoxic activity by the presence of serum; produces DNA protein cross-links and DNA strand breaks in cells; and inhibits macromolecular synthesis with a preferential inhibitory effect on protein synthesis relative to DNA and RNA synthesis. 31P nuclear magnetic resonance spectroscopy indicated that the compound is stable in the presence of serum proteins, thiols, or disulfides and that it reacts with Cu(II) resulting in the formation of a Cu(I)DPPE complex. The results of these in vivo and in vitro experiments suggest that the contrasting pharmacological profile of [Au(DPPE)2]Cl with respect to other gold(I) phosphine complexes may be related to both the kinetic stability of the complex and its stability in the presence of thiols.
Concept of Automatic Usability Evaluation of Safety-Critical Interactive Systems in the Field (Konzept der automatischen Bewertung der Gebrauchstauglichkeit sicherheitskritischer Systeme) (2008)

Summary The usability of interactive systems is an important attribute, especially for safety-critical devices like driver information systems. The functional complexity of such devices is increasing. Traditional user testing during development often fails to provide necessary data for an appropriate usability evaluation. In this work an approach for in-the-field usage data collection using the D'PUIS framework and automatic evaluation with the REVISER evaluation tool is introduced.
Fast kernel MUSIC algorithm (2002)

Estimating parameters of closely spaced multiple signals has received much attention in the fields of radar and sonar. The multiple signal classification (MUSIC) algorithm has been considered the most effective. However, MUSIC requires much computation because of the analysis of the MUSIC eigenspectrum (/spl Psi/) and the eigenvalue analysis of the covariance matrix C to estimate the noise vectors. Shimotahira (see Proc. ICASSP., vol.2, p.909-12, 1995 and IEICE Trans. Fundamentals, vol.E79-A, 1996) proposed the kernel MUSIC algorithm (K-MUSIC) which shortens its signal processing time. However, it does not change the fundamental points; C is formed and all noise vectors are used for /spl Psi/. The fast kernel MUSIC algorithm (F-K-MUSIC) is proposed. In F-K-MUSIC, all we have to do is to estimate a reduced number of noise vectors without the formation of C and to analyze /spl Psi/ with only one noise vector. The reduction of the processing time of F-K-MUSIC ranges from one hundredth to one thousandth of that of MUSIC were shown by numerical simulations.
[Effects of fluorouracil-induced Flt3 Ligand gene expression transcriptional regulated by Egr-1 promoter sequences]. (2009)

The therapy of hematopoietic growth factor gene regulated by Egr-1 promoter can protect hematopoiesis from 5-Fu injury.
Treatment of pancreatic cancer with anti-death receptor antibody in combination with Gemcitabine (2005)

DeRosier, Leo C. MD; Buchsbaum, Donald PhD; Sellers, Jeffrey BS; Huang, Zhi-Qiang; Oliver, Patsy PhD; Vickers, Selwyn MD Author Information
Holographic characteristics of organo-metallic compound-doped PQ: PMMA photopolymers (2004)

Photopolymers have been applied widely in optical devices for communications, displays, bio-sensing, and data storage. The advantages of this material are easy to synthesize, high refractive index change, high sensitivity and good optical quality. Recently, we have investigated on the syntheses and analysis of 9,10-PhenanthreneQuinone doped Poly(MethylMethAcrylate) (PQ:PMMA) photopolymer. This material can be fabricated with large dimensions and with thickness in the range of several-centimeters. Experiments show that the material shrinkage is negligible after optical exposure such that our doped photopolymer is attractive for volume holographic applications. However, comparing with other photopolymers, our PQ:PMMA material has a drawback of lower sensitivity (~10 mW/cm<sup>2</sup>). In this presentation, we demonstrate that by adding organo-metallic compound (Zinc MethylAcrylate, ZnMA) into the PQ:PMMA photopolymer, we succeeded in reducing response time and increasing holographic diffraction efficiency of the material. We report the fabrication and experimental investigation of dye-doped photopolymer, and discuss their application for data storage.
Severe acute hepatitis in a printing company worker: A case study (2014)

These clinical and pathological findings indicate that exposure to chlorinated organic solvents may have induced severe acute hepatitis in this patient.
Flaccid Blister (2018)

ABSTRACT Teledermatology is a term to describe the provision of dermatologic medical services through telecommunication technology. This is a teledermatology case of a flaccid blister.
Processing and properties of iridium alloys for space power applications (1994)

Iridium alloys are used as fuel cladding in radioisotope thermoelectric generators due to their high-melting point, high- temperature strength, and oxidation and corrosion resistance. Although iridium has a face-centered cubic crystal structure, it undergoes a distinct ductile-to-brittle transition characteristic of many body-centered cubic metals. Improved ductility in the alloys is achieved through material purification and controlled alloy additions at the parts per million (ppm) level. A vacuum arc remelt operation produces a nearly defect-free casting, which is further processed to sheet products. A change in processing from drop castings of small arc-melted buttons to large arc-remelted ingots has substantially improved product yields. The effects of processing changes on alloy microstructure, sheet textures, oxidation effects, high-strain-rate ductility, and fabricability are discussed.
One-Pot Deconstruction and Conversion of Lignocellulose Into Reducing Sugars by Pyridinium-Based Ionic Liquid–Metal Salt System (2020)

Constantly decreasing fossil resources and exceeding energy demands are the most alarming concerns nowadays. The only way out is to develop efficient, safe, and economical biomass processing protocols that can lead toward biofuels and fine chemicals. This research is one of such consequences involving the deconstruction and conversion of wheat straw carbohydrate constituents into reducing sugars via one-pot reaction promoted by Lewis acidic pyridinium-based ionic liquids (PyILs) mixed with different metal salts (MCl). Various parameters such as the type of metal salt, loading amount of metal salt, time, temperature, particle size of biomass, and water content which affect the deconstruction of wheat straw have been evaluated and optimized. Among the studied ionic liquid (IL) and metal salt systems, the best results were obtained with [BMPy]<sup>+</sup> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup><mml:mrow><mml:mtext>CoCl</mml:mtext></mml:mrow> <mml:mrow><mml:mn>3</mml:mn></mml:mrow> <mml:mrow><mml:mo>-</mml:mo></mml:mrow> </mml:msubsup> </mml:math> . The dinitrosalicylic acid (DNS) assay was used to determine the percentage of total reducing sugars (TRS) generated during treatment of wheat straw. The deconstructed wheat straw was characterized with various analytical tools, that is, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and X-ray powder diffraction (XRD) analyses. The IL-metal salt system was recycled for subsequent treatment of wheat straw. Statistical parameters were calculated from analysis of variance (ANOVA) at the 0.05 level of confidence.
High-pressure synthesis, structural and complex magnetic properties of the ordered double perovskite Pb<sub>2</sub>NiReO<sub>6</sub> (2013)

The ordered double perovskite Pb2NiReO6 has been prepared at 6 GPa and temperatures ranging from 1273 to 1373 K. Its crystal structure determined by X-ray powder diffraction and selected area electron diffraction shows monoclinic symmetry with centrosymmetric space group I2/m (a = 5.6021(1) Å, b = 5.6235(1) Å, c = 7.9286(1) Å and β = 90.284°(1)). High angle annular dark field microscopy studies reveal the existence of compositional microdomains. The compound displays a re-entrant spin-glass transition from a ferrimagnetic ordering below T(N) ~ 37 K between the Re(+5) and Ni(+3) (high spin configuration) magnetic sublattices to a spin-glass configuration. Magnetic field dependent magnetization measurements revealed wasp-waisted hysteresis loops at 5 K. These shaped features originate from the antiferromagnetic/ferromagnetic (AFM/FM) competing interactions.
Fast simulation of large-scale planar circuits using an object-oriented sparse solver (2003)

This paper presents a novel approach based on sparse matrix techniques to the assembly and inversion of linear systems that result from numerical modeling of planar structures using the method of moments (MoM). In order to render moment matrices as sparse as possible, one can take advantage of different types and levels of sparseness, both natural and approximate. For efficient storage and inversion of sparse linear systems, a block decomposition of the moment matrix is proposed. The software implementation of this approach in a CAD package demands full utilization of object-oriented programming techniques.
Three-dimensional multivoxel proton MR spectroscopy of the brain in children with neurofibromatosis type 1. (1999)

Three-dimensional multivoxel proton MR spectroscopy reveals distinct metabolic features that differentiate normal, FASI, and tumor regions in the pediatric brain.
Expression of the TPα and TPβ isoforms of the thromboxane prostanoid receptor (TP) in prostate cancer: clinical significance and diagnostic potential (2016)

The prostanoid thromboxane (TX)A2 plays a central role in haemostasis and is increasingly implicated in cancer progression. TXA2 signals through two T Prostanoid receptor (TP) isoforms termed TPα and TPβ, with both encoded by the TBXA2R gene. Despite exhibiting several functional and regulatory differences, the role of the individual TP isoforms in neoplastic diseases is largely unknown.This study evaluated expression of the TPα and TPβ isoforms in tumour microarrays of the benign prostate and different pathological (Gleason) grades of prostate cancer (PCa). Expression of TPβ was significantly increased in PCa relative to benign tissue and strongly correlated with increasing Gleason grade. Furthermore, higher TPβ expression was associated with increased risk of biochemical recurrence (BCR) and significantly shorter disease-free survival time in patients post-surgery. While TPα was more variably expressed than TPβ in PCa, increased/high TPα expression within the tumour also trended toward increased BCR and shorter disease-free survival time. Comparative genomic CpG DNA methylation analysis revealed substantial differences in the extent of methylation of the promoter regions of the TBXA2R that specifically regulate expression of TPα and TPβ, respectively, both in benign prostate and in clinically-derived tissue representative of precursor lesions and progressive stages of PCa. Collectively, TPα and TPβ expression is differentially regulated both in the benign and tumourigenic prostate, and coincides with clinical pathology and altered CpG methylation of the TBXA2R gene. Analysis of TPβ, or a combination of TPα/TPβ, expression levels may have significant clinical potential as a diagnostic biomarker and predictor of PCa disease recurrence.
Bestimmung stationärer Zwischenstoffkonzentrationen. II. Die Entstehung der Ketokörper und ihre Beziehung zur Glykolyse (1954)

Article Bestimmung stationärer Zwischenstoffkonzentrationen. II. Die Entstehung der Ketokörper und ihre Beziehung zur Glykolyse was published on January 1, 1954 in the journal Biological Chemistry (volume 297, issue Jahresband).
Unusual Pattern of Bone Marrow Somatic Mutation in Pediatric Patients Referred for Cytogenetic Analysis (2005)

Bone marrow somatic mutation frequency, as mea­sured by the glycophorin A (GPA) assay in circulating red blood cells, has been found to be increased in some hered­itable disease syndromes associated with constitutional malformation, mental retardation, cancer susceptibility and premature aging. Increased spontaneous GPA mutation frequency has been shown to be diagnostic for ataxia tel­angiectasia (AT) and Fanconi’s anemia (FA). We have applied the GPA assay to a 11 pediatric patients referred for cytogenetic analysis for a variety of reasons, including developmental delay and dysmorphology. There was no evidence of any cytogenetic abnormality in these patients, so we investigated the possible role of constitutive genom­ic instability expressed as a high frequency of bone mar­row somatic mutation. These patients had normal overall levels of GPA somatic mutation when compared to new­born and pediatric controls. When phenotypic subsets of mutants were considered, however, the patients had de­creased levels of simple allele loss mutation and increased levels of allele loss and duplication. Such a shift in types of mutation without an accompanying increase in overall mutation is difficult to understand, but may be related to inherent cytotoxic susceptibility and cellular inviability in this heterogeneous patient population.
Nahfeldoptik mit atomarer Auflösung? (1995)

Abstract Nahfeld‐optische Techniken werden intensiv erforscht und verbessert, um eine wesentlich höher ortsauflösende optische Mikroskopie zu erhalten. Anwendungen der nahfeld‐optischen Mikroskopie reichen von festkörperphysikalischen Problemen bei tiefen Temperaturen über Untersuchungen an Halbleiterproben bis zu biologischen Fragestellungen. Eine ungelöste Frage ist dabei die maximale mögliche Auflösung. In diesem Beitrag möchten wir an ausgewählten Beispielen aufzeigen, welche Konzepte verfolgt werden. Ihre Stärken und Schwächen werden kritisch analysiert und eine Wertung des Entwicklungspotentials wird versucht.
Bifurcating flows of plunging aerofoils at high Strouhal numbers (2012)

Abstract Force and particle image velocimetry measurements were conducted on a NACA 0012 aerofoil undergoing small-amplitude high-frequency plunging oscillation at low Reynolds numbers and angles of attack in the range 0– $2{0}^{\ensuremath{\circ} } $ . For angles of attack less than or equal to the stall angle, at high Strouhal numbers, significant bifurcations are observed in the time-averaged lift coefficient resulting in two lift-coefficient branches. The upper branch is associated with an upwards deflected jet, and the lower branch is associated with a downwards deflected jet. These branches are stable and highly repeatable, and are achieved by increasing or decreasing the frequency in the experiments. Increasing frequency refers to starting from stationary and increasing the frequency very slowly (while waiting for the flow to reach an asymptotic state after each change in frequency); decreasing frequency refers to impulsively starting at the maximum frequency and decreasing the frequency very slowly. For the latter case, angle of attack, starting position and initial acceleration rate are also parameters in determining which branch is selected. The bifurcation behaviour is closely related to the properties of the trailing-edge vortices. The bifurcation was therefore not observed for very small plunge amplitudes or frequencies due to insufficient trailing-edge vortex strength, nor at larger angles of attack due to greater asymmetry in the strength of the trailing-edge vortices, which creates a preference for a downward deflected jet. Vortex strength and asymmetry parameters are derived from the circulation measurements. It is shown that the most appropriate strength parameter in determining the onset of deflected jets is the circulation normalized by the plunge velocity.