gebhart/patrepeval huggingface dataset:
N‐Glycosylation analysis of formalin fixed paraffin embedded samples by capillary electrophoresis (2015)

In this study, N-linked glycans from intact, formalin treated and formalin fixed paraffin embedded (FFPE) standard glycoproteins, human serum and mouse tumor tissue samples were investigated in respect to their susceptibility for formaldehyde treatment mediated changes. FFPE samples were first deparaffinized, followed by solubilization in radioimmunoprecipitation assay buffer and treated with PNGase F for N-glycan release. The released glycans were labeled with a charged fluorophore and analyzed by capillary electrophoresis with laser induced fluorescent detection. No significant alterations were found in the N-glycome profile at any of the investigated complexation levels (i.e., glycoprotein, serum and tissue samples) of the study. These results suggest that FFPE samples can be readily used for global N-glycome analysis holding the promise to find novel carbohydrate biomarkers in prospective and retrospective studies. Exoglycosidase based carbohydrate sequencing was also applied to reveal some basic structural information about the N-linked carbohydrates of the mouse tumor tissue samples.
Electrical resistance: an atomistic view (2004)

This tutorial article presents a "bottom-up" view of electrical resistance starting from something really small, like a molecule, and then discussing the issues that arises as we move to bigger conductors. Remarkably, no serious quantum mechanics is needed to understand electrical conduction through something really small, except for unusual things like the Kondo effect that are seen only for a special range of parameters. This article starts with energy level diagrams (section 2), shows that the broadening that accompanies coupling limits the conductance to a maximum of q^2/h per level (sections 3, 4), describes how a change in the shape of the self-consistent potential profile can turn a symmetric current-voltage characteristic into a rectifying one (sections 5, 6), shows that many interesting effects in molecular electronics can be understood in terms of a simple model (section 7), introduces the non-equilibrium Green function (NEGF) formalism as a sophisticated version of this simple model with ordinary numbers replaced by appropriate matrices (section 8) and ends with a personal view of unsolved problems in the field of nanoscale electron transport (section 9). Appendix A discusses the Coulomb blockade regime of transport, while appendix B presents a formal derivation of the NEGF equations. MATLAB codes for numerical examples are listed in the appendix C.
Physics Basis for a Spherical Torus Power Plant (1999)

The spherical torus, or low-aspect-ratio tokamak, is considered as the basis for a fusion power plant. A special class of wall-stabilized high-beta high-bootstrap fraction low-aspect-ratio tokamak equilibrium are analyzed with respect to MHD stability, bootstrap current and external current drive, poloidal field system requirements, power and particle exhaust and plasma operating regime. Overall systems optimization leads to a choice of aspect ratio A = 1:6, plasma elongation kappa = 3:4, and triangularity delta = 0:64. The design value for the plasma toroidal beta is 50%, corresponding to beta N = 7:4, which is 10% below the ideal stability limit. The bootstrap fraction of 99% greatly alleviates the current drive requirements, which are met by tangential neutral beam injection. The design is such that 45% of the thermal power is radiated in the plasma by Bremsstrahlung and trace Krypton, with Neon in the scrapeoff layer radiating the remainder.
Comparative study of neutral carriers in polymeric lithium ion selective electrodes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparative study of neutral carriers in polymeric lithium ion selective electrodesV. P. Y. Gadzekpo, J. M. Hungerford, A. M. Kadry, Y. A. Ibrahim, R. Y. Xie, and Gary D. ChristianCite this: Anal. Chem. 1986, 58, 9, 1948–1953Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ac00122a007https://doi.org/10.1021/ac00122a007research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oxidation of aminophenols by 4a-hydroperoxy-5-ethyllumiflavin anion. Flavoenzyme hydroxylase mechanism (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of aminophenols by 4a-hydroperoxy-5-ethyllumiflavin anion. Flavoenzyme hydroxylase mechanismSam Rok Keum, Don H. Gregory, and Thomas C. BruiceCite this: J. Am. Chem. Soc. 1990, 112, 7, 2711–2715Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ja00163a037https://doi.org/10.1021/ja00163a037research-articleACS PublicationsRequest reuse permissionsArticle Views235Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of<i>n</i>-butyrate on adenovirus gene expression (1987)

Sodium butyrate affects viral gene expression of adenovirus with differences which depend upon the gene being expressed. In general, viral protein synthesis seems to be less affected than cellular protein synthesis. The amount of inhibition varies for each individual protein. Viral production is also inhibited in the presence of n-butyrate.
Management Options for Patients With Proven GERD and Persistent Symptoms on Proton Pump Inhibitors (2017)

Introduction: Management of patients with proven gastroesophageal reflux disease (GERD) and persistent symptoms despite proton pump inhibitors (PPIs) is controversial. The aim of this study was to assess expert opinion on treatment for distinct GERD profiles characterized by PPI unresponsive symptoms. Methods: The RAND UCLA Appropriateness Method was prospectively applied to hypothetical profiles with proven GERD (positive pH monitoring or endoscopy) and persistent symptoms despite double dose PPI undergoing pH-impedance monitoring on PPI. A priori thresholds included: acid exposure time (AET) >6.0%; symptom-reflux association (SRA): symptom index >50% and symptom association probability >95%; increased number of reflux events >80; large hiatal hernia (HH): >3cm. The primary outcome was appropriateness of four invasive treatment options (laparoscopic fundoplication (LF), magnetic sphincter augmentation (MSA), transoral incisionless fundoplication (TIF), radiofrequency energy delivery (RFED)) among eight profiles based on the above thresholds (total 32 scenarios). The secondary outcome was preferred use of pharmacologic and behavioral therapy. Results: Fourteen esophagologists (mean age 58.8 years, 93% male, mean 25.9 years in practice) previously involved in GERD consensus development participated in the study. LF was ranked as highly appropriate for profiles with abnormal AET, and moderately appropriate for patients with normal AET, positive SRA and large HH with regurgitation. MSA was ranked as moderately appropriate for profiles with abnormal AET without a large HH. TIF and RFED were not ranked as appropriate in any scenario (Figure). The group identified two highly appropriate quality measures (Table). Noninvasive options preferred included histamine-2 receptor antagonists for abnormal AET, transient lower esophageal sphincter relaxation inhibitors for abnormal reflux episodes, and neuromodulation for positive SRA.Figure: Data presented as % agreement, Median (Min-Max). Green cells represent moderate (60-79%) to high (80-100%) agreement for appropriateness, gray cells represent low agreement (1-59%) for appropriateness, and red cells represent 0% agreement for appropriateness. Acid exposure time (AET); Symptom reflux association (SRA); Hiatal hernia (HH).Table: Table. Scenarios ranked with agreement as highly appropriate quality measures.Conclusion: For treatment of PPI unresponsive symptoms in patients with proven GERD, an expert panel recommendations are: 1) Invasive therapy requires abnormal reflux burden in the form of abnormal AET (± large HH), or positive SRA with large HH and regurgitation (LF for all three scenarios; MSA for small/no HH). 2) TIF and RFED are not preferred in any of the PPI unresponsive profiles evaluated, in part due to a decline in outcomes over time. 3) Overall, medical/behavioral therapies are preferred for the other, likely functional in nature, scenarios.
Enzyme Kinetics: The Steady-State Approach (2014)

One-substrate kinetics.- Inhibitors, activators and inactivators.- pH effects.- More than one substrate.- The King and Altman procedure.- Non-linear kinetics and the concept of allosteric interaction.
Emission spectral width broadening for InGaAsP/InP superluminescent diodes (1991)

This is a study of emission spectral width broadening for 1.3 μm and 1.5 μm InGaAsP/InP superluminescent diodes (SLDs). It proposes two new fabricated structures, stacked active layer (STAC) and tandem active layer (TANAC), and confirms that the emission spectral widths can be successfully broadened for both. By applying these new active layer structures to laser diodes (LDs), two new functions are demonstrated. One is wavelength-switching in STAC LDs and the other is SLD/LD mode switching in TANAC LDs.
Survival of Escherichia coli O157:H7 on Cattle Hides (2011)

ABSTRACT The objective of this study was to determine the time period that Escherichia coli O157:H7 survives on the hides of cattle. Extensive research has been conducted and is ongoing to identify and develop novel preharvest intervention strategies to reduce the presence of E. coli O157:H7 on live cattle and subsequent transfer to processed carcasses. If a reduction of E. coli O157:H7 levels in feces can be achieved through preharvest intervention, it is not known how long it would take for such reductions to be seen on the hide. In the study presented herein, three trials were conducted to follow E. coli O157:H7 hide prevalence over time. For each trial, 36 animals were housed in individual stanchions to minimize or prevent hide contamination events. Through prevalence determination and isolate genotyping with pulsed-field gel electrophoresis, survival of E. coli O157:H7 on the hides of live cattle was determined to be short lived, with an approximate duration of 9 days or less. The results of this study suggest that any preharvest interventions that are to be administered at the end of the finishing period will achieve maximum effect in reducing E. coli O157:H7 levels on cattle hides if given 9 days before the cattle are presented for processing. However, it should be noted that interventions reducing pathogen shedding would also contribute to decreasing hide contamination through lowering the contamination load of the processing plant lairage environment, regardless of the time of application.
Protocole de routage BGP-IV (2003)

Dans le cadre du déploiement massif du réseau Internet, l’acheminement du trafic IP fait appel à l’activation de protocoles de routage dynamique chargés de déterminer le meilleur chemin possible pour atteindre une destination donnée, moyennant l’activation d’algorithmes de calcul de routes plus ou moins complexes. Cet article présente les principes du protocole BGP qui permet à des routeurs d'échanger des informations d'accessibilité de réseaux IP.
Terrein, an Optically Active Prostaglandin Synthon of Fungal Origin. I. Chemical Conversion to a Corey-type Lactone (1977)

1 ( R ) , 5 ( R ) , 8 ( R ) -Hydroxy-6-(3-0x0-trans-1-octenyl) -3-oxo-2oxabicyclo[3.3.0loct-6-ene(g), a flexible synthon suitable for the preparation of numerous natural and unnatural analogs of prostaglandin, has been synthesized from the optically active and readily available mold metabolite, terrein (1).Terrein ( 1) is a well-known mold metabolite available in satisfactory quantities via fermentation of a variety of Aspergillus 1-4 species.It has been shown to possess the same absolute configuration at C4 as do the prostaglandins at the corresponding C1l +Dedicated to Professor R. B.
A Point Mutation in the c- <i>myc</i> Locus of a Burkitt Lymphoma Abolishes Binding of a Nuclear Protein (1988)

A 20-base pair region in the first intron of the human c-myc gene was identified as the binding site of a nuclear protein. This binding site is mutated in five out of seven Burkitt lymphomas sequenced to date. To investigate the protein-recognition region in greater detail, the abnormal c-myc allele from a Burkitt lymphoma line (PA682) that carries a t(8;22) chromosomal translocation was used. A point mutation in the binding region of the PA682 c-myc DNA abolished binding of this nuclear protein. This protein may be an important factor for control of c-myc expression, and mutations in its recognition sequence may be associated with c-myc activation in many cases of Burkitt lymphoma.
Physical properties of silane-treated sugar palm fiber reinforced thermoplastic polyurethane composites (2018)

Fiber modifications are widely utilized to enhance the interface of fiber and matrix adhesion based on eco-friendly fibers such as sugar palm fibers. The sugar palm (SP) fibers in particle size of 150-250µm were immersed in 2 wt. % silane for 3hrs in this research. Composites of untreated and treated sugar palm fibers reinforced thermoplastic polyurethane (TPU) with different fiber loadings, ranging from 0 to 50 wt. % were then prepared by melt mixing compounding followed by hot pressing moulding. The physical property such as density, water absorption and thickness swelling of the composites were evaluated. Ten replicates of SP/TPU composites with the standard dimension were immersed in distilled water for 168hrs. The chemical changes for untreated and treated through Fourier-transform infrared spectroscopy (FTIR) was done to distinguish the untreated and silane treated of the SP/TPU composites. Increasing the fiber content resulted in higher water uptake and thickness swelling. Moreover, the silane treated SP/TPU composites was shown reducing water absorption and thickness swelling properties. This study is a part of exploration potential application of the composites for automotive part applications.
<title>Computer-aided fit testing: an approach for examining the user/equipment interface</title> (1997)

Developments in laser digitizing technology now make it possible to capture very accurate 3D images of the surface of the human body in less than 20 seconds. Applications for the images range from animation of movie characters to the design and visualization of clothing and individual equipment (CIE). In this paper we focus on modeling the user/equipment interface. Defining the relative geometry between user and equipment provides a better understanding of equipment performance, and can make the design cycle more efficient. Computer-aided fit testing (CAFT) is the application of graphical and statistical techniques to visualize and quantify the human/equipment interface in virtual space. In short, CAFT looks to measure the relative geometry between a user and his or her equipment. The design cycle changes with the introducing CAFT; now some evaluation may be done in the CAD environment prior to prototyping. CAFT may be applied in two general ways: (1) to aid in the creation of new equipment designs and (2) to evaluate current designs for compliance to performance specifications. We demonstrate the application of CAFT with two examples. First, we show how a prototype helmet may be evaluated for fit, and second we demonstrate how CAFT may be used to measure body armor coverage.
Effects of long-term incubation in seawater on the ability of Escherichia coli cells to incorporate histidine and maltose (1994)

Journal Article Effects of long‐term incubation in seawater on the ability of Escherichia coli cells to incorporate histidine and maltose Get access G. N. Flatau, G. N. Flatau INSERM Unité 303, Nice G. N. Flatau, INSERM Unité 303, I avenue Jean Lorrain, 06300 Nice, France. Search for other works by this author on: Oxford Academic Google Scholar D. Brunet, D. Brunet IUT de Tours, Tours, France Search for other works by this author on: Oxford Academic Google Scholar M. J. Gauthier M. J. Gauthier INSERM Unité 303, Nice Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 18, Issue 5, 1 May 1994, Pages 257–259, https://doi.org/10.1111/j.1472-765X.1994.tb00863.x Published: 01 May 1994 Article history Accepted: 26 November 1993 Published: 01 May 1994
<title>Stokes vectors, Mueller matrices, and polarized scattered light: experimental applications to optical surfaces and all other scatterers</title> (1991)

We discuss scattering in the context of the Stokes vectors and Mueller matrices that characterize the interaction. In order to study surface structures using light-scattering techniques it is useful to examine the nature of light scattered from perfect and perturbed mirror surfaces.
Blood and lymph node T lymphocytes in cutaneous T cell lymphoma: evaluation by light microscopy. (1979)

Cytology of peripheral blood and lymph node lymphocytes from a group of unselected patients with cutaneous T cell lymphoma (CTCL) was studied by light microscopy. Twenty of 45 patients had circulating lymphocytes with convoluted nuclei recognized in routine Wright-Giemsa-stained peripheral blood smears. Cytocentrifuge preparations of E-rosetted lymphocytes showed that greater than 10% of the T cells had convoluted nuclei in each of 16 patients with positive blood smears and in six of 17 whose blood smears were negative or inconclusive. Peripheral blood involvement with greater than 10% convoluted T cells was most frequent in patients with erythroderma (100%) including those with normal of decreased lymphocyte counts, and was not uncommon in patients with mycosis fungoides in the plaque or tumor phase (42%). The light-microscopic morphology of the abnormal cells found in the patients with the plaque or tumor phase of mycosis fungoides was not distinguishable from that of the erythrodermic patients. Increased percentages (less than 15%) of T cells having convoluted nuclei were also found in the lymph node cell suspensions from CTCL patients with adenopathy (18 of 25 patients). These results suggest that a high frequency of extracutaneous involvement occurs in patient with CTCL, the clinical significance of which remains to be determined.
Renal function in rats treated with cyclosporin following unilateral nephrectomy. (1985)

The effects of oral cyclosporin A (25 mg/kg/day) on renal function and structure in groups of normal, laparotomized and unilaterally nephrectomized DA rats was assessed over a 4-week period. In each group, the drug caused impairment of function, although there was evidence of improvement during the course of the study. Cyclosporin A toxicity was most marked in the nephrectomized animals, where histological examination at 4 weeks revealed extensive damage to proximal straight tubular cells. Only minimal structural damage was observed in the two other groups. Cyclosporin A concentrations in whole blood and kidney were estimated by radioimmunoassay at 4 weeks. Similar drug levels were found in normal, laparotomized and nephrectomized animals, except for an unexplained fall in blood levels in the laparotomy group. The significance of these observations is discussed in the context of current knowledge concerning the physiological effects, toxicology and pharmacology of cyclosporin A.
Molecular characterization of a xyloglucan-specific endo-(14)-beta-d-glucanase (xyloglucan endo-transglycosylase) from nasturtium seeds (1993)

A novel xyloglucan-specific endo-(1-->4)-beta-D-glucanase, involved in the post-germinative mobilization of xyloglucan storage reserves, has previously been isolated from nasturtium (Tropaeolum majus L.) seed. Its mode of action has been shown, in vitro, to be one of transglycosylation except at low substrate (glycosylacceptor) concentrations when hydrolysis predominates. Here it is shown that this nasturtium seed xyloglucan endo-transglycosylase is encoded by a single gene which is transcribed and processed to a 1.5 kb mRNA. The isolation and DNA sequence analysis of a cDNA copy of the nasturtium xyloglucan endo-transglycosylase transcript is described. The cDNA encodes a 33.5 kDa precursor polypeptide which is subsequently processed to a 31 kDa mature protein. The precursor incorporates an N-terminal signal sequence which probably contains information relevant to the targeting of the enzyme to the cell wall. The computer-predicted isoelectric point (5.14) and low (approximately 0%) alpha-helix content of the deduced mature protein are in excellent agreement with the experimental data obtained using the purified enzyme. The deduced protein sequence lacks homology with known plant endo-(1-->4)-beta-D-glucanases, consistent with the unique properties of the enzyme. Database searches have revealed that a Brassica protein (meri-5) of previously unknown function, but abundantly expressed in expanding tissue, shares structural identity with the nasturtium xyloglucan endo-transglycosylase. The expression of a xyloglucan endo-transglycosylase in expanding tissue would be consistent with the contention that enzymes of this type are involved in cell wall loosening.
Ultrasound Promoted Bromination of Activated Arenes with<i>N</i>-Bromosuccinimide (1995)

Abstract Ultrasound irradiation has resulted in the selective monobromination of activated aromatics with N-Bromosuccinimide (NBS) in carbon tetrachloride at ambient conditions in the absence of any added catalyst.