gebhart/patrepeval huggingface dataset:
Bisphosphonate Zoledronic Acid (ZOL) Inhibits the Abnormal Proliferation and Differentiation of Juvenile Myelomonocytic Leukemia (JMML) Cells. (2004)

Abstract BACKGROUND: JMML is a clonal myeloprolifelative/myelodysplastic disorder of early childhood. The mortality rate in JMML patients is high, but so far, stem cell transplantation is the only therapy capable of producing durable remissions. JMML cells are characterized by the ability to spontaneously proliferate in vitro, giving rise to granulocyte-macrophage (GM) colonies. Deregulation of the GM-CSF receptor-RAS signal transduction pathway is thought to play a key role in the pathogenesis. Therefore, putative RAS-blocking compounds can be potential inhibitors for JMML cells. ZOL, the third generation bisphosphonate, is known to not only treat bone diseases but also act as an antiproliferative drug for some cancers by inhibiting the activation of RAS-related proteins. We then investigated the effect of ZOL on JMML cell growth in vitro. METHODS: After obtaining informed consent, bone marrow (BM) samples were obtained from children with JMML or normal healthy volunteers. The diagnosis of JMML was based on criteria of the international JMML Working Group, and confirmed by the demonstration of spontaneous colony formation, most of which were GM colonies consisting of both macrophages and granulocytes. In methylcellulose clonal and suspension cultures, BM non-adherent mononuclear cells (2 x 104 cells/mL) in the absence or presence of GM-CSF (10 ng/mL) were exposed to 0, 1, 10 and 100 μM of ZOL. In the former, colonies (&gt;40 cells) were counted on days 12 to 14 of culture, and the cellular composition of each colony was analyzed on cytospin smears cytochemically stained. In the latter, the determination of number of cultured cells and their cellular composition by the microscopic observation and flow cytometry was carried out on days 0, 5, 10 and 15. FINDINGS: 8 JMML children were enrolled in this study. In clonal culture, ZOL did not affect the spontaneous colony formation by JMML cells at 1 μM, but reduced it at 10 μM. Few colonies were produced at 100 μM. Interestingly, the colonies formed at more than 10 μM ZOL contained a number of smaller colonies consisting of only granulocytes, but no macrophages. Furthermore, the size of bipotential GM colonies was smaller and the percentage of macrophages included in each colony was fewer at the concentrations of ZOL. On the other hand, ZOL had no effect on the colony formation induced by GM-CSF from normal BM cells at up to 10 μM, whereas few colonies were observed at 100 μM as well as spontaneous colony formation by JMML cells. In suspension culture, 10 μM ZOL also inhibited the spontaneous proliferation and differentiation on monocyte/macrophage lineage of JMML cells, but not the development of normal BM cells induced by GM-CSF. INTERPRETATION: The inhibitory effects of ZOL on the abnormal proliferation and differentiation of JMML cells may offer an approach to therapy in JMML.
[Combination chemotherapy with adriamycin, carboquone and 5-Fu for bladder cancer]. (1983)

We treated 25 bladder cancer patients with combined cytotoxic chemotherapy of adriamycin (10--20 mg/day administration on days 1, 2 and 3), carboquone (4 mg/day administration on day 1 of weeks 3, 4 and 5 and 5-Fu (200 mg/day for 5 weeks) or futraful suppositories (750 mg/day for 5 weeks) as one course. According to the Koyama - Saitoh criteria, CR + PR was observed in 4 (17.4%) of 23 patients excluding the 2 dropout patients. According to Karnofsky's criteria, an effect with chemotherapy was observed in 9 (39.1%) of the 23 patients. There was a relatively good response rate in a group of 12 patients with the superficial tumors as compared with a group of 11 patients with the deep tumors. There were no severe adverse reactions.
The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary disease (2010)

A combination of ICS and LABA reduced mortality by approximately 20%. Neither tiotropium nor LABA by itself modifies all-cause mortality in COPD.
The effects of solcoseryl on the growth and multiplication of chick embryo fibroblasts cultivated "in vitro". (1979)

The action of Solcoseryl, a free protein extract of calf blood, was studied on chick embryo fibroblasts cultivated in vitro. Solcoseryl stimulates the permitotic DNA synthesis and increases the number of mitoses.,
Abstract 16546: LCZ696, an Angiotensin Receptor-Neprilysin Inhibitor, Increases Nitric Oxide Bioavailability and Improves Vascular Function in Ischemic Heart Failure (2017)

Introduction: LCZ696 combines the ARB valsartan and the neprilysin inhibitor sacubitril. This combination was shown to improve cardiac function more than ACEi in patients leading to its approval for heart failure (HF) with reduced ejection fraction. Purpose: Endothelial and vascular dysfunction have been implicated in the progression of HF and are potential therapeutic targets. The effects of LCZ696 on nitric oxide (NO) bioavailability and vascular function have not been studied. Methods: Male spontaneously hypertensive rats (SHRs) were subjected to 45 mins of left coronary artery ligation and reperfusion (Rep) for up to 12 wks. Daily oral therapy with vehicle, 31 mg/kg valsartan, or 68 mg/kg LCZ696 was initiated 4 wks post-Rep. Vasoreactivity responses of the thoracic aorta were assessed in vitro using acetylcholine (ACh, 0.1nM-10mM) and sodium nitroprusside (SNP, 0.1nM-10mM) following precontraction with phenylephrine (PE, 1μM). Circulating and myocardial NO bioavailability was determined by measuring p...
Behavior of sample means of nearly nonstationary time series (1986)

Sample means are perhaps the most commonly used statistics in data analysis. When the data points are independent, behavior of sample means is governed by the Law of Large Numbers. When the data are serial correlated, theoretical results of stationary stochastic processes are often used to describe the behavior of sample means. How do the sample mean behave when data are nonstationary (or nearly so) is yet to be discussed. In this paper, I give the limiting distribution of sample means when the processes are either nonstationary or nearly nonstationary. I also discuss why the conventional formula fails to provide adequate inference for sample means when the processes are nearly nonstationary.
The trunk follows the feet : an approach for making a quadruped robot trot and walk (2006)

first, the confirmation of a proposed interaction partner by immunoblotting, and second, the identification of new interaction partners by mass spectrometry analysis. Moreover, even low affinity, transient PPIs are detectable by this technique. Finally, Membrane-SPINE is adaptable to almost any cell type, making it applicable as a powerful screening tool to identify PPIs of membrane proteins.
Short-range order in β-NiAl microalloyed with iron (1998)

Abstract Results of a quantitative analysis of fluorescence extended X-ray absorption fine structure are presented obtained at the Fe and Ni K absorption edges of a β-NiAl sample microalloyed with iron. The concentration of Fe was 0.2 at.% substituting for Ni. The quantitative analysis results in a suggestion of a local structure model for the neighbourhood of Ni as well as of Fe atoms. Results show that Fe atoms at this low content do not occupy Ni sites in the B2 structure nor sites in clusters of α-Fe. They rather indicate that small clusters of Fe-Ni are formed which crystallize similar to either the Cu type or to the ordered phase FeNi3 in the Cu3Au type.
Triphenylamine-based stimuli-responsive solid state fluorescent materials (2020)

Molecular engineering of triphenylamine (TPA) units produced multi-stimuli-responsive solid state fluorescent materials.
A 160-MHz analog equalizer for magnetic disk read channels (1997)

This paper presents a 160-MHz five-tap adaptive analog equalizer for magnetic recording disk drive read channels. The design is based on a direct form finite impulse response (FIR) architecture which includes four key features: signal shuffling in the analog domain to improve noise performance, use of a master sample-and-hold stage to improve the dynamic performance and clock jitter of the clock recovery loop, use of an additional sample-and-hold stage to accommodate settling time requirements and reduce power, and use of a time interleaved sign-sign LMS algorithm which permits coefficient adaptation at low power and area. This equalizer occupies 1.36 mm/sup 2/ and consumes only 240 mW with 5-V supply voltage. It is fabricated in BiCMOS technology with 0.8-/spl mu/m CMOS and 0.72-/spl mu/m/sup 2/ NPN, 3LM, and DP capacitor.
Invitation to the Bispectrum (1988)

Abstract : This bispectrum is examined from a variety of physical and mathematical perspectives. Particular stress is placed on those examples or approaches which aid intuitive understanding of the bispectrum and its properties. A key contribution of this work is the discovery and detailed development of a time series model which can reproduce any possible bispectrum. This model is used to discuss practical concerns relating to the bispectrum such as sampling and estimation issues. Keywords: Bispectrum; Cross spectrum; Frequency coupling; Higher order spectrum; Non-Guassianity; Nonlinear signals.
[Surgical treatment for popliteal artery occlusive disease]. (2010)

The cause of popliteal artery occlusive disease are diverse. Treatment for popliteal artery occlusive disease should depend on its etiology to make the outcomes be satisfied.
Unique Nature of an Attenuated Strain of Tobacco Mosaic Virus: Autoregulation (1984)

An attenuated strain L11A of tobacco mosaic virus (TMV) multiplied like wild type strain L at an early stage of infection in tomato leaves. Four days after inoculation, however, multiplication of L11A was drastically reduced (autoregulation) compared with the constant multiplication of L. In mixed infections, L11A strongly inhibited the multiplication of homologous strain L. Experiments with cucumber mosaic virus (CMV) or tobacco plants revealed that the inhibitory mechanism of L11A is not host-specific but virus-specific, and the autoregulatory mechanism is effective only for TMV. RNA synthesis in L11A infected leaves 4 days after inoculation was studied by polyacrylamide gel electrophoresis. Synthesis of TMV-RNA and its replicative intermediate were strongly inhibited, whereas the replicative form of TMV-RNA and ribosomal RNA were synthesized as in the case of L infection. Synthesis of non-coat-protein was studied by the incorporation of radioactive histidine into subcellular fractions derived from leaves infected with L or L11A for 4 days. Different patterns of the two strains in protein synthesis were noted. At least three proteins were predominantly synthesized in L11A infection. One of them was observed in the mitochondria fraction. From its position in polyacrylamide gel, it could be viral coded 165K protein which is considered to be involved in viral RNA replication. These results suggest that the unique nature of attenuated virus L11A, i.e. autoregulation, resulted from the inhibitory mechanism of viral RNA synthesis due to overproduction of 165K protein and is quite distinct from interferon, intrinsic interference or interference by defective virus.
(A) Fibroblasts expressing P1b EGFP were immunolabeled using antibodies to vim (a and f), GFP (b and g), and cyt (c and h) (2011)

Note the P1b colocalization with both mitochondria and IF networks in defined regions (e). In cells expressing high levels of the fusion protein (f–j), a collapse of mitochondrial as well as IF networks was observed. Boxed areas in panels d and i are shown enlarged in panels e and j, respectively. Bars: (a–d and f–i) 20 μm; (e and j) 5 μm. (B) Cells expressing P1 instead of P1b. Bar, 20 μm. (C) Immortalized wt and P0 fibroblasts were fractionated, and equal amounts of total lysates and cytosolic and mitochondrial fractions were analyzed. (D and E) Signal intensities of protein bands in C were densiometrically measured and normalized to the signals of actin (D) or ATPS (E). Values (mean ± SEM) represent protein levels of cytosolic (D) and mitochondrial fractions (E). (F) Fibroblasts derived from wt and P1b mice were subjected to subcellular fractionation and analyzed by immunoblotting. White lines indicate that intervening lanes have been spliced out. (G) Statistical analyses of data shown in F (mean ± SEM). **, P < 0.01; ***, P < 0.001.<b>Copyright information:</b>Taken from "Plectin isoform 1b mediates mitochondrion–intermediate filament network linkage and controls organelle shape"The Journal of Cell Biology 2008;181(6):903-911.Published online 16 Jun 2008PMCID:PMC2426950.
Silicon Absolute X-Ray Detectors (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation John F. Seely, Raj Korde, Jacob Sprunck, Kadda Medjoubi, Stephanie Hustache; Silicon Absolute X‐Ray Detectors. AIP Conf. Proc. 23 June 2010; 1234 (1): 842–845. https://doi.org/10.1063/1.3463346 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Quantum channel capacity by simulated annealing (2005)

It is shown how simulated annealing can be used to determine the accessible information and the capacity of a quantum channel. The method is applied to a specific example of a symmetric $N$-state quantum channel that frequently appears in the analysis of eavesdropping in quantum key distribution protocols. The numerical results for the accessible information of this quantum channel are compared with recently published analytical solutions showing excellent agreement. Furthermore, interesting results concerning the capacity of a symmetric quantum channel are presented.
Hepatic artery infusion for recurrent or chemoresistant hepatic malignancy. (2011)

351 Background: Previously treated hepatic colorectal metastases (CRC) and advanced hepatocellular cancer (HCC) are tumor challenges frequently unresponsive to systemic chemotherapy (CT). We reviewed survival outcome in chemoresistant/high-risk patients following hepatic artery infusion (HAI) in 21 CRC pts, 10 HCC pts, and 6 miscellaneous metastatic cancers. Methods: Patient groups: 21 CRC pts (16 M, 5 F), mean age 63, 16 had metachronous (DFI-17 mos), and 5 synchronous CA; liver extent: 76% multiple (>5) mets or extensive bilateral, CEA (ng/m), >100, 8 pts > 50 (3 pts) < 5 (3 pts) and NA = 7 pts. Previous CT:FU/LV (11pts), oxaliplatin (OX) or irinotecan (IR) (10 pts). Liver surgery: partial resection/RFA = 9 pts. HCC = 9 pts, cholangio CA (1), M/F 5/5; av. age 63. Previous RX hepatic lobectomy 4 pts, RFA/TACE = 3 patients. Miscellaneous GP (therapy): hepatic lobectomy + HAI were done in metastatic lung (1), breast (1), advanced gall bladder cancer (GBCA) (T 3-4) (2 pts); HAI alone was done in Br. CA (1) carcinoid (1) treatment protocols: CRC protocol: HAI-FUDR 12-15 mg/kg/d, dexamethasone 2mg.kg/d, leucovorin 20 mg/m 2 /d (14 d) plus bolus infusion (d1), oxaliplatin (OX) 130 mg/m 2 (or cisplatin (CIS) 100 mg/m 2 d1); systemic RX: d20-30. OX I.V. 130 mg/m 2 , capecitabine 750-1,000 mg/m 2 /d x 10 days (also used in Miscel. Grp.) HCC Protocol: HAI-14 d as in CRC Protocol. Bolus infusion d1-doxorubicin 75 mg/m 2 or OX or CIS as in CRC schema. Results: CRC:OS-CRC post start HAI = med/16mos., 2yr/5yr = 27%/6%. HCC OS = 9 mos. Median (3-12 mos in 9 evaluable pts.; 1 HCC pt, with recurrence 2 yr. post central hepatectomy was treated over 3.5 yrs. with HAI + RFA/TACE – (OS-67mo). Miscellaneous group included lung (11 mos) Br CA (23, 9 mos) adv. Carcinoid (3 mos), GBCA (2 pts > 60 mos). Major complications: pump malfunction (4 pts), misperfusion (2) pts, infected pocket (2) pts, duodenal fistula (1) pt. Conclusions: Hepatic artery infusion alternating with systemic chemo therapy has apparent survival benefit in selected patients with persistent or progressive chemo resistant malignancy from metastatic CRC, HCC, or selected miscellaneous cancers (breast, lung, liver, gall bladder cancer) and warrants further study. No significant financial relationships to disclose.
Experiments on Active Control of Seismic Structures (1988)

This paper presents the first phase of a comprehensive experimental study concerning the possible application of active control to structures under seismic excitations. In the laboratory, a single‐degree‐of‐freedom model structure was used which was controlled using prestressing tendons connected to a servohydraulic actuator. An optimal closed‐loop control scheme using a quadratic performance index was employed to reduce the response of structure under base motion generated by a large‐scale seismic simulator. The time delay between the observed motion and the implemented control forces, an important factor in control implementation, was integrated in the control algorithm. Using a carefully designed, fabricated, and calibrated experimental setup, the correlation between the analytical and experimental results was studied. Based on similitude relations, the experimental results obtained for the model structure were extrapolated to the full‐scale structures and are analyzed.
ChemInform Abstract: APPLICATIONS OF THE PERACID‐MEDIATED OXIDATION OF ALCOHOLS (1977)

Abstract Bei der Behandlung mit überschüssiger m‐Chlorperbenzoesäure und anschließender Oxidation mit weiterer Persäure in Gegenwart katalytischer Mengen an 2,2,6,6‐Tetramethylpiperidinhydrochlorid erhält man aus 5‐Norbornen‐2‐ol (I) das Epoxy‐keton (II).
Improved Activity and Modulated Action Pattern Obtained by Random Mutagenesis at the Fourth β-α Loop Involved in Substrate Binding to the Catalytic (β/α)8-Barrel Domain of Barley α-Amylase 1 (1997)

The functionality of the sequence Arg183-Gly184-Tyr185 of the substrate binding fourth beta-alpha loop in the (beta/alpha)8-barrel of barley alpha-amylase isozyme 1 (AMY1) was studied by random mutagenesis. A motif of polar Gly184 hydrophobic residues was present in active mutants, selected by starch plate screening of yeast transformants. Gly184 was important, probably due to the carbonyl group binding to Ca2+ and the spatial proximity of Phe181. Mutation of both flanking residues as in Ser183-Gly184-Met185 (SGM-) and TGL-AMY1 decreased the Ca2+ affinity. SGM-AMY1 has 2-fold increased activity for amylose but reduced activity on maltooligosaccharides, whereas KGY-AMY1 has up to 3-fold elevated activity toward the oligosaccharides. TGL-AMY1 has modest activity on all substrates. Shifted action pattern on maltooligosaccharides for NGY-, SGM-, and TGL-AMY1 support that Arg183 in wild type is located at subsites +1 and +2, accommodating two sugar rings toward the reducing end from the site of cleavage. In the crystal structure of barley alpha-amylase 2 (AMY2), Lys182 (equivalent to AMY1 Arg183) is hydrogen-bonded with sugar OH-3 in subsite +2. Higher Ki app for acarbose inhibition of KGY-AMY1 and parent AMY1 compared with the other mutants suggests favorable substrate interactions for Arg/Lys183. KGY-AMY1 was not inhibited by the AMY2-specific proteinaceous barley alpha-amylase/subtilisin inhibitor, although Lys182 of AMY2 is salt-linked to the inhibitor.
Direct FuelCell/Turbine Power Plant (2004)

This report includes the progress in development of Direct Fuel Cell/Turbine. (DFC/T.) power plants for generation of clean power at very high efficiencies. The DFC/T power system is based on an indirectly heated gas turbine to supplement fuel cell generated power. The DFC/T power generation concept extends the high efficiency of the fuel cell by utilizing the fuel cell's byproduct heat in a Brayton cycle. Features of the DFC/T system include: electrical efficiencies of up to 75% on natural gas, 60% on coal gas, minimal emissions, simplicity in design, direct reforming internal to the fuel cell, reduced carbon dioxide release to the environment, and potential cost competitiveness with existing combined cycle power plants. FCE successfully completed testing of the pre-alpha sub-MW DFC/T power plant. This power plant was constructed by integration of a 250kW fuel cell stack and a microturbine. Following these proof-of-concept tests, a stand-alone test of the microturbine verified the turbine power output expectations at an elevated (representative of the packaged unit condition) turbine inlet temperature. Preliminary design of the packaged sub-MW alpha DFC/T unit has been completed and procurement activity has been initiated. The preliminary design of a 40 MW power plant including the key equipment layout and the site plan was completed. A preliminary cost estimate for the 40 MW DFC/T plant has also been prepared. The tests of the cascaded fuel cell concept for achieving high fuel utilizations were completed. The tests demonstrated that the concept results in higher power plant efficiency. Alternate stack flow geometries for increased power output/fuel utilization capabilities are also being evaluated.
Isolation of Gelatin from Ancient Bones (1959)

The isolation and characterization of gelatin from 12,000-year-old deer antlers is described. Use of gelatin from ancient bones for carbon-14 dating may improve the accuracy of the dating procedure because gelatin is not likely to be contaminated by extraneous carbon.
Impact of Phase Ripple In Fiber Bragg Grating Based Tunable Dispersion Compensator On 10 Gb/s NRZ Transmission (2007)

The influence of phase response ripple on the performance of a tunable dispersion compensator using fiber Bragg grating-based distributed Gires-Tournois etalons is investigated experimentally for 10 Gb/s NRZ transmission. The results reveal the implications of the phase ripple profile on the dispersion compensating performance.
Report on the workshop on heterogenous database systems held at Northwestern University Evanston, Illinois, December 11-13, 1989 sponsored by NSF (1990)

article Free Access Share on Report on the workshop on heterogenous database systems held at Northwestern University Evanston, Illinois, December 11-13, 1989 sponsored by NSF Authors: Peter Scheuermann View Profile , Clement Yu View Profile , Ahmed Elmagarmid View Profile , Frank Manola View Profile , Arnon Rosenthal View Profile , Hector Garcia-Molina View Profile , Dennis McLeod View Profile , Marjorie Templeton View Profile Authors Info & Claims ACM SIGMOD RecordVolume 19Issue 4Dec. 1990 pp 23–31https://doi.org/10.1145/122058.122060Published:01 December 1990Publication History 21citation76DownloadsMetricsTotal Citations21Total Downloads76Last 12 Months7Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF