gebhart/patrepeval huggingface dataset:
Enhanced Bioactivity of Collagen Fiber Functionalized with Room Temperature Atomic Layer Deposited Titania (2018)

Surface modifications of a biomaterial like collagen are crucial in improving the surface properties and thus enhancing the functionality and performance of such a material for a variety of biomedical applications. In this study, a commercially available collagen membrane's surface was functionalized by depositing an ultrathin film of titania or titanium dioxide (TiO<sub>2</sub>) using a room temperature atomic layer deposition (ALD) process. A novel titanium precursor-oxidizer combination was used for this process in a custom-made ALD reactor. Surface characterizations revealed successful deposition of uniform, conformal TiO<sub>2</sub> thin film on the collagen fibrillar surface, and consequently, the fibers became thicker making the membrane pores smaller. The in vitro bioactivity of the ALD-TiO<sub>2</sub> thin film coated collagen was investigated for the first time using cell proliferation and a calcium phosphate mineralization assay. The TiO<sub>2</sub>-coated collagen demonstrated improved biocompatibility promoting higher growth and proliferation of human osteoblastic and mesenchymal stem cells when compared to that of noncoated collagen. A higher level of calcium phosphate or apatite formation was observed on ALD modified collagen surface as compared to that on noncoated collagen. Therefore, this novel material can be promising in bone tissue engineering applications.
Explaining the Familial Colorectal Cancer Risk Associated with Mismatch Repair (MMR)-Deficient and MMR-Stable Tumors (2007)

The information from our analyses should be useful in quantifying familial risks in clinical practice and in the design of studies to identify novel disease alleles.
Ipsilateral ABR with Cochlear Implant (1996)

Ipsilateral ABR recording technique was developed with the MXM DIGISONIC DX10 cochlear implant, involving, firstly, setting of recording variables with regard to implant and ABR constraints, and, secondly, enhancement of recording quality by signal processing. The resulting recording quality then enabled us to characterize ABR latency, amplitude and wave reproductibility according to stimulus intensity and stimulation site (electrode stimulated). The findings agree with those of the literature on contralateral human and ipsilateral animal studies. Waves III and V amplitude increased with stimulus intensity. Waves III and V latency was insensitive to stimulus intensity or site. ABR quality diminished basally.
A fully integrated analog frontend macro for cable modem applications in 0.18µm CMOS (2001)

An analog front-end (AFE) module designed for use together with a cable modem transceiver on one single die is presented. All the analog functionality is implemented in a pure 0.18µm CMOS process with 1.8V supply. Besides the critical requirements towards substrate- and supply-isolation, the design of the high-order anti-aliasing filter, the high performance ADC and the low jitter PLL are most challenging. With a silicon area of 9.9mm2and a power dissipation of less than 1 Watt, this 3-channel AFE can be considered a reference design for first-IF sampling (SAW-less) cable modem systems.
Differential expression of glycosylphosphatidylinositol-anchored proteins in a murine T cell hybridoma mutant producing limiting amounts of the glycolipid core. Implications for paroxysmal nocturnal hemoglobinuria. (1992)

A T cell hybridoma mutant, which expressed a markedly reduced level of glycosylphosphatidylinositol (GPI)-anchored proteins on the cell surface, was characterized. The surface expression level of Thy-1 was approximately 17% of the wild-type level, whereas the surface expression of Ly-6A was approximately 2.4% of the wild-type level. We show here that these cells synthesized limiting amounts of the GPI core and that the underlying defect in these cells was an inability to synthesize dolichyl phosphate mannose (Dol-P-Man) at the normal level. The defect in Ly-6A expression could be partially corrected by tunicamycin, which blocked the biosynthesis of N-linked oligosaccharide precursors and shunted Dol-P-Man to the GPI pathway. Full restoration of Thy-1 and Ly-6A expression, however, required the stable transfection of a yeast Dol-P-Man synthase gene into the mutants. These results revealed that when the GPI core is limiting, there is a differential transfer of the available GPI core to proteins that contain GPI-anchor attachment sequences. Our findings also have implications for the elucidation of the defects in paroxysmal nocturnal hemoglobinuria.
Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes (2014)

Our five-subtype classification provides a comprehensive overview of HPV(+) as well as HPV(-) HNSCC biology with significant translational implications for biomarker development and personalized care for patients with HNSCC.
SBS Suppression Using a Multichannel Tunable Laser with Data-Encoding Capability (1998)

Abstract We demonstrate stimulated Brillouin scattering (SBS) using a new laser transmitter. The device uses an integrated FM modulator for both SBS suppression and channel tuning, and an integrated AM modulator for data encoding. We measure thresholds of 25 dBm on four separate wavelength division multiplexing channels. The required modulation signal is very small, 95 mVpp, and the residual AM is only 1 %. Keywords: Multichannel Laser On-chip Data Encoding Sbs Suppression Wavelength Tunable Wdm
Clinical and Histoimmunophenotypic Findings and Association with Epstein—Barr Virus in 16 Cases (1995)

Waldeyer's ring is an uncommon, rarely reported primary site for Hodgkin's disease. We report a series of 16 such cases culled from the files of the Armed Forces Institute of Pathology and the National Cancer Institute. The patients' median age was 41 years (range, 14-74), and they presented with airway obstruction or unilateral tonsillar enlargement. The disease was localized to the Waldeyer's ring (stage I) in 46% of patients and extended to the cervical lymph nodes (stage II) in 39% and to the spleen (stage III) in 15%. Local radiation therapy, with or without chemotherapy, obtained a complete response in all but two patients. There was local recurrence in one patient and distant spread in three others. All patients for whom follow-up is available are alive without evidence of disease at 9 to 216 months (median, 20 months) except two who died of widespread Hodgkin's disease and two others who died of other causes. Histologically, eight cases were classified as mixed cellularity type (50%), four as nodular sclerosis (25%), and one as lymphocyte predominance, nodular (LPn; 6.3%); three others that showed interfollicular involvement were unclassified (18.7%). The Reed-Sternberg (RS) and atypical mononuclear cells in most cases of mixed cellularity and interfollicular types and all cases of nodular sclerosis had the classic immunophenotype (CD45-, CD20- and/or CD45RO-, CD15+ and/or CD30+). In the single case of LPn, they were of B-cell lineage (CD45+, CD20+, CD45RO-, CD15-, CD30-). In situ hybridization performed on routinely processed sections revealed Epstein-Barr virus (EBV) EBER1 mRNA in RS cells of eight of 12 cases studied (67%) only in mixed cellularity and nodular sclerosis, but not in LPn. We conclude that, however rarely, Hodgkin's disease of typical morphology and immunophenotype can originate in Waldeyer's ring. The incidence of EBV detection in the RS cells in our study is greater than that usually seen in nodal Hodgkin's disease in the United States. The greater prevalence of EBV-related Hodgkin's disease at this site is probably a reflection of the fact that the Waldeyer's ring is a reservoir for EBV.
Remarks on quasilinearization applied in boundary-layer calculations. (1966)

Quasi-linearization applied in boundary layer calculations, noting simple flow over solid surface
Extended front-to-back alignment capability for MEMS/MOEMS applications (2002)

A novel front-to-back alignment method, which does not require additional alignment sensors, is being developed for optical projection lithography tools. The system is designed such that it can be easily retrofitted to existing systems. By embedding a pair of tiny optics into the wafer stage, the existing Through-the-Lens (TTL) and/or Off-Axis (OA) alignment systems can be utilized, thereby avoiding the added complexity of supplementary alignment electronics and hardware. The front-to-back alignment is accomplished by imaging the alignment marks on the wafer back surface to the front and then using the standard front-side alignment system. To calibrate the front-to-back alignment module and to minimize the alignment errors, new metrology software is introduced. The front-to-back alignment accuracy is specified to be <EQ 500 nm, which provides typically twice the improvement compared to current state-of-the-art implementations. The front-to-back alignment capability is being developed in response to the requirements of the MEMS/MOEMS market.
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth (2004)

Mice carrying a hepatocyte-specific inactivation of the glucorticoid receptor (GR) gene show a dramatic reduction in body size. Growth hormone signaling mediated by the Stat5 transcription factors is impaired. We show that Stat5 proteins physically interact with GR and GR is present in vivo on Stat5-dependent IGF-I and ALS regulatory regions. Interestingly, mice with a DNA-binding-deficient GR but an unaltered ability to interact with STAT5 (GR(dim/dim)) have a normal body size and normal levels of Stat5-dependent mRNAs. These findings strongly support the model in which GR acts as a coactivator for Stat5-dependent transcription upon GH stimulation and reveal an essential role of hepatic GR in the control of body growth.
Up-regulation of Acid-gated Na+ Channels (ASICs) by Cystic Fibrosis Transmembrane Conductance Regulator Co-expression in Xenopus Oocytes (2002)

Cystic fibrosis transmembrane conductance regulator (CFTR) functions as both a chloride channel and an epithelial transport regulator, interacting with Na(+) (epithelial sodium channel), Cl(-), renal outer medullary potassium channel(+), and H(2)O channels and some exchangers (i.e. Na(+)/H(+)) and co-transporters (Na(+)-HCO(3)(minus sign), Na(+)-K(+)-2Cl(-)). Acid-sensitive ion channels (ASICs), members of the epithelial sodium channel/degenerin superfamily, were originally cloned from neuronal tissue, and recently localized in epithelia. Because CFTR has been immunocytochemically and functionally identified in rat, murine, and human brain, the regulation of ASICs by CFTR was tested in oocytes. Our observations show that the proton-gated Na(+) current formed by the heteromultimeric ASIC1a/2a channel was up-regulated by wild type but not by Delta F508-CFTR. In contrast, the acid-gated Na(+) current associated with either the homomultimeric ASIC1a or ASIC2a channel was not influenced by wild type CFTR. The apparent equilibrium dissociation constant for extracellular Na(+) for ASIC1a/2a was increased by CFTR, but CFTR had no effect on the gating behavior or acid sensitivity of ASIC1a/2a. CFTR had no effect on the pH activation of ASIC1a/2a. We conclude that wild type CFTR elevates the acid-gated Na(+) current of ASIC1a/2a in part by altering the kinetics of extracellular Na(+) interaction.
Cell-type specific impact of glucocorticoid receptor activation on the developing brain (2020)

Abstract A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing health outcomes. Excess GR-activation in utero has been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type specific effects. To address this, we used an in vitro model of fetal human brain, induced pluripotent-stem-cell-derived cerebral organoids, and mapped GR-activation effects using single-cell transcriptomics across development. Interestingly, neurons showed targeted regulation of differentiation- and maturation-related transcripts, suggesting a delay of these processes upon GR-activation. Uniquely in neurons, differentially-expressed transcripts were significantly enriched for genes associated with behavior-related phenotypes and disorders. This suggests that aberrant GR-activation could impact proper neuronal maturation, leading to increased disease susceptibility, through neurodevelopmental processes at the interface of genetic susceptibility and environmental exposure.
Biomarkers of food intake and metabolite differences between plasma and red blood cell matrices; a human metabolomic profile approach (2013)

Untargeted metabolomic analyses of plasma and red blood cells (RBCs) can provide complementary information on biomarkers of food consumption. To assess blood collection differences in biomarkers, fasting blood was drawn from 10 healthy individuals using sodium citrate and lithium heparin as anticoagulants. Plasma and RBCs were separated into aqueous and lipid fractions to be analyzed using 1D and 2D (1)H NMR spectroscopy. Fatty acids were analyzed using gas chromatography-mass spectrometry (GC-MS). Polyphenols were extracted from plasma and RBCs by micro-elution solid-phase extraction and analyzed by ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). (1)H NMR demonstrated higher aqueous metabolites such as glucose in plasma compared to RBCs, while RBCs contained higher ADP-ATP, creatine and acetone than plasma. Lipoproteins and their subclasses were higher in plasma than in RBCs. Percentages of saturated fatty acids (SFA) 16 : 0, 17 : 0, 20 : 0, 24 : 0 and polyunsaturated fatty acids (PUFA) 22 : 6 n-3 (docosahexaenoic acid) and 20 : 4 n-6 (arachidonic acid) were higher in RBCs than in plasma (p < 0.05), while SFA 14 : 0, monounsaturated fatty acids (MUFA) 14 : 1 n-5, 16 : 1 n-7, 17 : 1 n-7 and 18 : 1 n-9 and PUFA 18 : 3 n-3, 18 : 2 n-6, 18 : 3 n-6 and 20 : 3 n-6 were higher in plasma than in RBCs (p < 0.05). Polyphenols differed in plasma from those of RBCs. Biomarker concentrations were lower in sodium citrate compared to lithium heparin plasma. In conclusion, metabolomic profiles generated by NMR spectroscopy, GC-MS and UPLC-MS/MS analyses of RBCs versus plasma show complementary information on several specific molecular biomarkers that could be applied in nutritional assessment.
ChemInform Abstract: Synthesis and Structure Analysis of Tetragonal Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub> with the Garnet‐Related Type Structure. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Choosing a Practical Screening Instrument to Identify Patients at Risk for Diabetic Foot Ulceration (1998)

To evaluate the sensitivity and specificity of 3 sensory perception testing instruments to screen for risk of diabetic foot ulceration.This case-control study prospectively measured the degree of peripheral sensory neuropathy in diabetic patients with and without foot ulcers. We enrolled 115 age-matched diabetic patients (40% male) with a case-control ratio of approximately 1:3 (30 cases and 85 controls) from a tertiary care diabetic foot specialty clinic. Cases were defined as individuals who had an existing foot ulceration or a history of a recently (< 4 weeks) healed foot ulceration. Controls were defined as subjects with no foot ulceration history. Using receiver operating characteristic analysis, we evaluated the sensitivity and specificity of 2 commonly used nephropathy assessment tools (vibration perception threshold testing and the Semmes-Weinstein 10-g monofilament wire system) and a 4-question verbal neuropathy score to evaluate for presence of foot ulceration.A vibration perception threshold testing using 25 V and lack of perception at 4 or more sites using the Semmes-Weinstein 10-g monofilament wire system had a significantly higher specificity than neuropathy score used. The neuropathy score was most sensitive when 1 or more answers were affirmative. When modalities were combined, particularly the monofilament wire system plus vibration perception threshold testing and the neuropathy score plus the monofilament wire system, there was a substantial increase in specificity with little or no diminution in sensitivity.The early detection of peripheral neuropathy or loss of "protective sensation" is paramount to instituting a structured treatment plan to prevent lower extremity amputation. The results of our study suggest that all 3 sensory perception testing instruments are sensitive in identifying patients at risk for ulceration. Combining modalities appears to increase specificity with very little or no diminution in sensitivity.
Confirmation of tensile residual stress reduction in electron beam welding using low transformation temperature materials (LTT) as localized metallurgical injection – Part 1: Metallographic analysis (2017)

Abstract For the reduction of the distortion and the residual tensile stresses in welded seams on carbon manganese steels, low transformation temperature materials (LTT) were developed. These materials use the volume expansion effect during martensitic transformation. The volume expansion counteracts volume shrinkage during cooling. The positive effects of the low transformation temperature alloys on the residual tensile stresses were demonstrated in various investigations. The low transformation temperature materials were, so far, used as filler material in arc welding processes in large volumes. The use of modular thermal fields of the electron beam welding processes offers the potential of a temporally activated use of compressive stress induction by phase transformation of the low transformation temperature alloys. The aim is to exert influence in situ on the welding residual stress state and thus on the distortion of complex parts. The metallographic analysis of an electron beam welded seam in unalloyed steel with low transformation temperature filler material is demonstrated. The evaluation is made via electron backscatter diffraction (EBSD) and is shown in the first part. The second part will show the effect on near surface residual stresses examined by hole-drilling method in combination with an optical evaluation by electronic speckle pattern interferometry.
Selective targeting of T cell subsets: focus on alefacept – a remittive therapy for psoriasis (2002)

Psoriasis is an immune-mediated disease in which memory-effector (CD45RO+), skin-homing T cells play a key role in driving the disease process. Available therapies are often poorly tolerated, none are curative and most only suppress disease symptoms without attacking the underlying cause of the illness. Alefacept (Ameviv, Biogen, Inc.) is a fully human lymphocyte function associated antigen-3/immunoglobulin G1 fusion protein that targets memory-effector T cells by binding CD2 on the T cell and Fc phi receptor III IgG receptors on accessory cells, thereby preventing T cell activation and proliferation and causing selective T cell apoptosis. To date, alefacept has been studied in moderate-to-severe chronic plaque psoriasis and in a pilot study of psoriatic arthritis. In chronic plaque psoriasis, alefacept produced significant and sustained improvements in psoriasis symptoms. There was no evidence of disease rebound or worsening of psoriasis following treatment cessation. Multiple courses provided consistent efficacy, with a trend for more rapid and greater clinical improvement in subsequent courses. Alefacept reduced circulating CD4+ and CD8+ memory-effector T cells, with relatively no change in naive (CD45RA+) T cells or B cells. Alefacept also reduced IFN-phi-secreting Tcells in lesional biopsies of psoriatic skin. These reductions all correlated with the observed clinical effect. Alefacept was well-tolerated throughout these studies, with a side effect profile similar to placebo. There was no evidence of generalised immunosuppression or increased risk of infection or malignancy. Alefacept did not alter the primary or acquired immune response in psoriatic patients. Clinical data obtained to date support the use of alefacept as a safe and remittive therapy for psoriasis.
Screening of symbiotic frankiae for host specificity by restriction fragment length polymorphism analysis (1990)

Restriction fragment length polymorphism analysis of numerous Frankia strains, using a nifDH probe, separated the strains into three distinct groups based on hybridization patterns. The groups identified in this study were well correlated with host specificity groups identified in earlier cross-inoculation studies.
Colorimetric Evaluation of a Set of Spectral Sensitivities (2008)

A colorimetric evaluation of an image acquisition device is important for evaluating and optimizing a set of sensors. We have already proposed a colorimetric evaluation model [J. Imaging Sci. Technol. 49(6), 588-593 (2005)] based on the Wiener estimation. The mean square errors (MSE) between the estimated and the actual fundamental vectors by the Wiener filter agrees quite well with the proposed model and we have shown that the estimation of the noise variance of the image acquisition system is essential to the evaluation model. We also have confirmed that the proposed model can be applied to two different reflectance recovery models and that the proposed colorimetric quality (Qc) can be estimated by applying these models without a prior knowledge of the spectral characteristics of the sensors, the recording illuminant and the noise present in the image acquisition device, which are required for the estimation by the Wiener model.In this paper, the effects of the sampling intervals of the spectral reflectance and the quantization error to the evaluation model are studied and it is confirmed from the experimental results that at least 8-bit depth of the image data and 20-nm sampling intervals are required to apply the evaluation model accurately.
Learning dexterous grasps that generalise to novel objects by combining hand and contact models (2014)

Generalising dexterous grasps to novel objects is an open problem. We show how to learn grasps for high DoF hands that generalise to novel objects, given as little as one demonstrated grasp. During grasp learning two types of probability density are learned that model the demonstrated grasp. The first density type (the contact model) models the relationship of an individual finger part to local surface features at its contact point. The second density type (the hand configuration model) models the whole hand configuration during the approach to grasp. When presented with a new object, many candidate grasps are generated, and a kinematically feasible grasp is selected that maximises the product of these densities. We demonstrate 31 successful grasps on novel objects (an 86% success rate), transferred from 16 training grasps. The method enables: transfer of dexterous grasps within object categories; across object categories; to and from objects where there is no complete model of the object available; and using two different dexterous hands.