gebhart/patrepeval huggingface dataset:
The anti-tumor activity of the 7A7 antibody, specific to murine EGFR, is independent of target expression levels in immunocompetent mice (2007)

El receptor para el factor de crecimiento epidermico (EGFR), una molecula altamente expresada en tumores epiteliales, provee un blanco clinicamente validado para el desarrollo de drogas anti-cancer. Los agentes de terapia pasiva anti-EGFR han mostrado actividad anti-tumoral en los escenarios pre-clinicos y clinicos, la optimizacion de estas terapias se encuentra actualmente bajo activa investigacion. Hasta el momento no ha sido encontrada una clara asociacion entre los niveles de expresion del EGFR y la respuesta a los agentes especificos por el EGFR. Una posible razon para esta interrogante pudiera ser la carencia de modelos pre-clinicos adecuados. Con esta idea en mente nosotros exploramos, por primera vez, si podia ser demostrada una correlacion entre la expresion del EGFR y la sensibilidad al tratamiento con un anticuerpo monoclonal (AcM) anti-EGFR, usando tumores murinos en hospederos singenicos normales y un anticuerpo especifico por el EGFR murino (AcM 7A7). Nosotros observamos que dos tumores murinos de pulmon (TC-1 y 3LL-D122) con equivalentes niveles de expresion del EGFR, muestran diferente sensibilidad al tratamiento con el AcM 7A7 a pesar de que una reduccion en la activacion del EGFR por el tratamiento con este anticuerpo fue obtenida en ambas. Las celulas TC-1 fueron indiferentes a la citotoxicidad dependiente de complemento (CDC) mediada por el AcM 7A7. Estos hallazgos demuestran que la efectividad de los AcMs anti-EGFR no depende exclusivamente de la expresion del EGFR en los tumores, sugiriendo ademas que el escape a la cascada del complemento podria representar un mecanismo de resistencia a la terapia anti-EGFR basada en anticuerpos
Adrenergic response in children with asthma on exogenous stimuli (1992)

In asthmatic children it was investigated whether the degree of impairment of the adrenergic response on exogenous stimuli is related to the magnitude of the 24-hour amplitude in airflow obstructions. Urinary-adrenaline and noradrenaline excretion after house dust mite (HDM) inhalation and after exercise was measured. Nine children with (group I), and nine without increased airflow obstruction overnight (group II) and nine age matched healthy children (group C) were included in the study. All patients showed an early obstructive reaction (EOR) after HDM challenge. Six children in group I and five in group II developed an EOR on exercise. A significant increase in urinary adrenaline excretion was observed after exercise in the control group (P < 0.05, values on the control and challenge day being 5.4 +/- 0.9 and 10.0 +/- 1.6 mumol/mol creat.). The same occurred for noradrenaline (P < 0.01, values being 28.2 +/- 2.5 and 49.0 +/- 5.7 mumol/mol creat.). Adrenergic response after both stimuli was impaired in the asthmatic groups, in group I more pronounced than in group II. Values from group I for adrenaline on the control day, HDM and exercise challenge were 6.0 +/- 0.8, 4.7 +/- 0.6, 6.0 +/- 1.0 and for noradrenaline 36.1 +/- 2.7, 27.2 +/- 2.3, 38.4 +/- 4.9 mumol/mol creat., respectively. Values from group II for adrenaline on these days were 5.6 42- 1.0, 3.7 42- 0.6 and 9.0 +/- 1.3 and for noradrenaline 28.3 +/- 3.2, 22.4 +/- 2.5, 41.3 +/- 5.9 mumol/mol creat., respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Properties of the Hydrogen Maser (1962)

Properties of the hydrogen maser and details of the apparatus are discussed. Experimental work is described which yields a new value for the hyperfine separation of hydrogen in its ground state. The result is Δ ν =1,420,405,762±4cps. This result is based on a value of the hyperfine separation in Cs 133 which is taken to be Δ ν (Cs 133 )=9,192,631,840cps.
Mycosporine-2-glycine is the major mycosporine-like amino acid in a unicellular cyanobacterium (<i>Euhalothece</i>sp.) isolated from a gypsum crust in a hypersaline saltern pond (2002)

Mycosporine-like amino acids (MAAs) were extracted from a unicellular cyanobacterium (Euhalothece sp.) isolated from a gypsum crust on the bottom of a hypersaline saltern pond in Eilat, Israel. When grown at high light intensities, this isolate contained high concentrations of two MAAs, one showing maximum optical density at 331 nm and one at 362 nm. The compound absorbing at 331 nm was purified by preparative high performance liquid chromatography, and its structure was elucidated by one-dimensional ((1)H and (13)C) and two-dimensional nuclear magnetic resonance, mass spectrometry and amino acid analysis, and identified as mycosporine-2-glycine. This is the first report of mycosporine-2-glycine in cyanobacteria.
NEONATAL RESPIRATORY DISTRESS: EXPERIENCE AT THE HOSPITAL FOR SICK CHILDREN, TORONTO, L960-1961. (1963)

Four hundred and thirty infants selectively referred to the Newborn Unit of The Hospital for Sick Children, Toronto, with the symptom of respiratory distress, were reviewed. There were 142 cases of the "idiopathic respiratory distress syndrome" (IRDS), of which 67 were fatal. The remainder included 100 cardiac (76 deaths), 63 extra-pulmonary (28 deaths) and 109 other specific pulmonary conditions (54 deaths). Of the 109, half were due to massive aspiration. Serial observations and radiographs led to correct clinical diagnosis in 85% of necropsy-proved cases of IRDS and in a comparable proportion of all other conditions. The incidence and mortality rate of IRDS were twice as high in males as in females. A significant number of premature infants have transient respiratory distress after birth, and diagnostic criteria for inclusion in any study should be defined in detail. This study emphasized the large contribution of disorders of the respiratory and cardiac systems to neonatal mortality and led to the formation of a special department for intensive care and research in these conditions.
ChemInform Abstract: 1,10‐Phenanthroline Derivatives as Ionophores for Alkali‐Metal Ions (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Radon Exposure, Cigarette Smoking, and Other Mining Experience in the Beaverlodge Uranium Miners Cohort (1991)

A nested case-control study within the Beaverlodge Uranium Miners Cohort was undertaken to assess any possible contribution of confounding by smoking and other mining experience to the risk estimate derived from the original cohort study. Next of kin have been interviewed for 46 lung cancer cases and 95 controls enrolled in the Beaverlodge Uranium Miners Cohort Study who died between 1950 and 1980. Confounding by cigarette smoking and other mining experience appears unlikely to have contributed to the relative risk coefficient for exposure to Rn decay products derived in the parent study. Data for smoking and exposure to Rn decay products are consistent with a multiplicative model, although considerable caution must be applied to this interpretation.
Learning large margin likelihoods for realtime head pose tracking (2009)

We consider the problem of head tracking and pose estimation in realtime from low resolution images. Tracking and pose recognition are treated as two coupled problems in a probabilistic framework: a template-based algorithm with multiple pose-specific reference models is used to determine jointly the position and the scale of the target and its head pose. Target representation is based on histograms of oriented gradients (HOG): descriptors which are at the same time robust under varying illumination, fast to compute and discriminative with respect to pose. To improve pose recognition accuracy, we define the likelihood as a parameterized function and we propose to learn it from training data with a new discriminative approach based on the large-margin paradigm. The performance of the learning algorithm and the tracking are evaluated on public images and video databases.
Fiber concrete tunnel lining : Construction of a subway line in Barcelona (2006)

The new subway line in Barcelona, Spain, will accommodate trains traveling in opposite directions, as well as platforms, in a tunnel almost 12 m (39 ft) in diameter and 42.6 km (26.5 miles) long at a depth of 30 to 70 m (100 to 230 ft) below the surface. This article describes the fiber concrete being used as the tunnel lining. To limit cracking, steel fiber-reinforced concrete (SFRC) was used in the precast tunnel segments. To determine the most appropriate concrete composition for the tunnel segments in terms of the design requirements and the conditions under which the segments would be fabricated, tests were performed on concrete reinforced with different types of steel fibers available in the European market. The optimum dosages of locally available high-range water-reducing admixtures (HRWRA) were determined so that benefit/cost ratios could be used to select a product. The mixture proportions were selected that would provide adequate workability and high early-age strength. The toughness of SFRC was evaluated to provide a basis for the choice of fiber types. The authors note that even though SFRC is not a common structural material, the precast plant rapidly adapted to its use. Because production of the segments is expected to proceed for at least a few years, the authors report that the Marsh cone test and BCR values are being used to study new HRWRAs and to determine their cost-effectiveness.
Localization of cellular src mRNA during development and in the differentiated bipolar neurons of the adult neural retina in Xiphophorus. (1989)

The expression of the c-src gene in embryonic and adult tissue of the teleost fish Xiphophorus helleri was analyzed by in-situ hybridization. The highly conserved fish c-src gene was found to be expressed at high levels in midterm embryos, where c-src mRNA was localized in developing neurons of the sensory layer of the differentiating retina and in the developing brain. In adult tissues the expression of c-src was found to persist in certain cell types of the brain and the neural retina, especially in the bipolar cells of the inner nuclear layer, which are postmitotic, fully differentiated mature neurons. Thus c-src in Xiphophorus appears to be a developmentally regulated proto-oncogene which is important for neuronal differentiation during organogenesis, but whose persistence of expression in certain terminally differentiated neurons strongly suggests a particular maintenance function for c-src in these cells as well.
Structural and biochemical characterization of a trapped coenzyme A adduct of<i>Caenorhabditis elegans</i>glucosamine-6-phosphate<i>N</i>-acetyltransferase 1 (2012)

Glucosamine-6-phosphate N-acetyltransferase 1 (GNA1) produces GlcNAc-6-phosphate from GlcN-6-phosphate and acetyl coenzyme A. Early mercury-labelling experiments implicated a conserved cysteine in the reaction mechanism, whereas recent structural data appear to support a mechanism in which this cysteine plays no role. Here, two crystal structures of Caenorhabditis elegans GNA1 are reported, revealing an unusual covalent complex between this cysteine and the coenzyme A product. Mass-spectrometric and reduction studies showed that this inactive covalent complex can be reactivated through reduction, yet mutagenesis of the cysteine supports a previously reported bi-bi mechanism. The data unify the apparently contradictory earlier reports on the role of a cysteine in the GNA1 active site.
Le charbon en Afrique australe (1930)

Célérier Jean. Le charbon en Afrique australe. In: Annales de Géographie, t. 39, n°222, 1930. pp. 664-665.
Fingerprint Structure Imaging Based on an Ultrasound Camera (1999)

Abstract This paper describes the design of an ultrasound camera which has a resolution of 0.1mm. The camera allows the observation of the near surface structures of solid objects and is suitable for the finger ridge pattern imaging (i.e., pattern which is reflected in a fingerprint). The device can be used for a biometric identification of individuals (for access verification). It can also be employed for all other sorts of structures which have ultrasound detectable changes in the near surface structure, both natural and artificial (e.g., created for information recording). The paper describes the current version of the camera and the physical phenomena behind its operation. Presented are also perspectives of further development of the device.
Poster: Head gesture 3D interface using a head mounted camera (2012)

In this paper, we propose a real world UI that uses head gestures. This UI detects user head motion obtained in images by head mounted camera (HMC). It estimates the relative position and distance between a user's head and objects user is viewing. To prevent erroneous judgment, a head-specific motion model is applied in gesture recognition. As a feedback to the user, detailed object information is displayed on head mounted display (HMD). This UI allows hands-free interaction with surrounding objects. We show the UI's effectiveness by experiments.
Comparative study between parallel and counter flow configurations between air and falling film desiccant in the presence of nanoparticle suspensions (2003)

A comparative numerical study is employed to investigate the heat and mass transfer between air and falling film desiccant in parallel and counter flow configurations. Nanoparticles suspensions are added to the falling film desiccant to study heat and mass transfer enhancements. The numerical results show that the parallel flow channel provides better dehumidification and cooling processes of the air than counter flow configuration for a wide range of pertinent parameters. Low air Reynolds number enhances the dehumidification and cooling rates of the air and high air Reynolds number improves the regeneration rate of the liquid desiccant. An increase in the channel height results in enhancing the dehumidification and cooling processes of air and regeneration rate of liquid desiccant. The dehumidification and cooling rates of air are improved with an increase in the volume fraction of nanoparticles and dispersion factor. Copyright © 2003 John Wiley & Sons, Ltd.
C224 Experimental Study on Gas-Liquid Flow Distributions in Multi-Pass Channels (2011)

The gas-liquid flow distribution in a multi-pass channel with horizontal headers and downward branches was examined experimentally. At first, the refrigerant two-phase flow in the channel was visualized to make clear the flow characteristics in the dividing and combining headers. Then, the air-water flow was observed and the air and water distribution ratios in the branches were measured under following four air and water velocity conditions at the header entrance: (a) equal superficial velocities, (b) equal kinetic energies, (c) equal quality and mass flow rate and (d) equal Baker flow pattern map parameters. The results obtained in the air-water flows were closely compared with those observed in the refrigerant flow. It was found that the condition of equal superficial velocities was most suitable for simulating the refrigerant two-phase flow.
Update On Monolithic Fuel Fabrication Development (2005)

Efforts to develop a viable monolithic research reactor fuel plate have continued at Idaho National Laboratory. These efforts have concentrated on both fabrication process refinement and scale-up to produce full sized fuel plates. Advancements have been made in the production of U-Mo foil including full sized foils. Progress has also been made in the friction stir welding and transient liquid phase bonding fabrication processes resulting in better bonding, more stable processes and the ability to fabricate larger fuel plates.
Selbstorganisation und photochemische Beeinflussung (1991)

Abstract Die Eigenschaften selbstorganisierender Systeme wie Flüssigkristalle, micellare und vesikuläre Systeme sowie Monoschichten können durch Licht beeinflußt werden. Daraus ergeben sich interessante Anwendungsmöglichkeiten, z. B. für die Datenspeicherung.
Untersuchung von Präparationsmittelmenge und Präparationsmittelgleichmäßigkeit bei Polyacrylnitrilfaserstoffen mittels Indikatoraktivierungsanalyse (1970)

Untersuchung von Präparationsmittelmenge und Präparationsmittelgleichmäßigkeit bei Polyacrylnitrilfaserstoffen mittels Indikatoraktivierungsanalyse was published in Band 21, Heft 7 Juli 1970 on page 271.
The lipid A region of lipopolysaccharides from Rhizobiaceae activates bone marrow granulocytes from lipopolysaccharide‐hyporesponsive C3H/HeJ andC57BL/10ScCr mice (2000)

We established in previous studies that the binding of Salmonella lipopolysaccharide (LPS) to constitutive receptors of low affinity triggers the expression of the inducible LPS-binding molecule CD14 in bone marrow cells (BMC) of C3H/HeOU mice, but not in BMC from C3H/HeJ mice. We show in this study that BMC from C3H/HeJ and C57BL/10ScCr mice do not express CD14 after exposure to LPSs from Salmonella enterica and Bordetella pertussis, but do express this marker when treated with several LPSs from Rhizobiaceae, or their lipid A fragments. This shows that the constitutive LPS receptor in BMC from C3H/HeJ and C57BL/10ScCr mice is fully able to trigger a complete signalling cascade. Results of cross-inhibition of the binding of radiolabelled LPS indicated that active LPSs (from R. species Sin-1 and R. galegae) and inactive LPSs (from S. enterica and B. pertussis) bind to the same site of the constitutive LPS receptor of C3H/HeJ cells. Furthermore, binding of R. species Sin-1 LPS, and signalling induced by this LPS, were both inhibited by pre-exposure of C3H/HeJ cells to B. pertussis lipid A. This correlation between binding and signalling suggests that in C3H/HeJ cells, the constitutive receptor, which recognizes a large panel of LPSs from different origins, appears selectively unable to be activated by some particular LPSs, such as those of Enterobacteria and Bordetella.
Safety analysis of the GEM Detector Magnet conductor (1993)

The safety of the GEM Detector Magnet is analyzed using a computational model to determine current sharing between the cabled conductor and the external aluminum stabilizer. The model includes inductive and transverse conductive effects due to the geometries of the coil and the conductor. A conservative analysis indicates a peak conductor hotspot temperature of {approximately} 50 K at two seconds after the initiation of quench. After this time, additional heating is limited because most of the current in the normal zone region is carried by the aluminum stabilizer and an external protection circuit should have begun to diminish the total current. The analysis shows that conductor safety requires adequate transverse conductivity between the cable and the aluminum stabilizer. The calculated transverse conductance of the GEM conductor, 1 {times} 10{sup 7} mho/m, is at least 100 times greater than the minimum value necessary to limit the hotspot temperature to {approximately} 50 K after two seconds. This report describes the results of calculations based on a realistic assumption of GEM conductor performance during a quench.
<title>Dynamically refocused Rayleigh laser beacons for atmospheric tomography</title> (2002)

We report initial results from a prototype system to generate multiple Rayleigh laser guide stars for adaptive optics from a single pulsed laser at 354 nm wavelength. A 3.2 mW laser pulsed at 630 Hz was used to project three beams on the sky simultaneously, each pulsed at 210 Hz. A spinning mirror was used to direct the pulses in three directions at the vertices of an equilateral triangle 90 arcsec across. Laser pulses were triggered by a synchronising electrical pulse from the motor. Dynamic focusing optics in the receiving telescope will in future be used to hold such beacons from more powerful lasers in focus over a height range of many kilometers. Multiple beacons can be used to derive tomographic information on the vertical distribution of the aberration. We show initial analytical and numerical work on how the unique features of refocused Rayleigh beacons can improve the tomographic wavefront measurement for multi-conjugate adaptive optics.
Reconstruction of 'simplified' skin: control of fabrication (1984)

Journal Article Reconstruction of ‘simplified’ skin: control of fabrication Get access D. ASSELINEAU, D. ASSELINEAU Centre International de Recherches Dermatologiques, Sophia Amipolis, 06565 Valbonne, France Search for other works by this author on: Oxford Academic Google Scholar M. PRUNIERAS M. PRUNIERAS Centre International de Recherches Dermatologiques, Sophia Amipolis, 06565 Valbonne, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s27, 1 July 1984, Pages 219–222, https://doi.org/10.1111/j.1365-2133.1984.tb15608.x Published: 01 July 1984
Multiscale modeling and simulation of drug release from cardiovascular stents (2008)

The newly developed Medical Artificial Intelligence Readiness Scale for Medical Students (MAIRS-MS) was found to be valid and reliable tool for evaluation and monitoring of perceived readiness levels of medical students on AI technologies and applications. Medical schools may follow 'a physician training perspective that is compatible with AI in medicine' to their curricula by using MAIRS-MS. This scale could be benefitted by medical and health science education institutions as a valuable curriculum development tool with its learner needs assessment and participants' end-course perceived readiness opportunities.
The Role of Corticotropin-releasing Factor in the Pathophysiology of Depression: Implications for Antidepressant Mechanisms of Action (2008)

CME Educational Objectives 1. Describe how antidepressants, as well as other psychiatric drugs, normalize the disturbances in CRF-containing circuits and HPA axis signaling and that these changes are associated with a favorable treatment response. 2. Assess how measures of disrupted CRFergic signaling and downstream changes in HPA axis functioning may be used to predict response to antidepressant treatment and risk of relapse. 3. Determine how individual genetic differences in CRF-related genes may influence predisposition or resiliency to psychiatric disorders as well as likelihood to respond to a given treatment.
A high incidence of nucleoside reverse transcriptase inhibitor (NRTI)-induced lactic acidosis in HIV-infected patients in a South African context. (2006)

The incidence rate is higher than reported in studies in developed countries. This may be due to d4T, which is recommended as a first-line antiretroviral drug in South Africa. This implication raises the question whether it is an appropriate drug in first-line treatment of patients with predisposing risk factors such as female gender and being overweight.
Characterization of Starch from Bread Aged at Different Temperatures (1987)

Abstract A series of bread samples stored at various temperatures (4°, 25°, and 40°C) were analyzed by differential scanning calorimetry (DSC) to determine if retrogradation (quantified by DSC enthalpy values) and storage temperature were correlated. The increase in enthalpy values during storage time was dependent on storage temperature. However, the rate of recrystallization was not linear at any of the temperatures studied. The net result was that the enthalpy values tended to converge with time, irrespective of storage temperature. Another effect of the increased storage temperature was an increase in the peak temperature (T p ) of the amylopectin endotherm. This indicates either that storage temperature affects the type of crystal being formed as the starch recrystallizes, or that annealing of crystals occurs at the higher storage temperatures. X‐ray diffractometry of starch isolated from the crumb gave similar diffraction patterns indicating no difference in crystal type among the treatments. In addition, the DSC endotherm became sharper at the higher temperatures. Thus, the increase in T p was apparently the result of annealing of the crystals at the higher storage temperatures.