gebhart/patrepeval huggingface dataset:
Case - control analysis of leukaemia among Chernobyl accident emergency workers residing in the Russian Federation, 1986 - 1993 (1997)

This paper presents an analysis of data of the Russian National Medical and Dosimetric Registry on the incidence of leukaemia among 155 680 male Chernobyl accident emergency workers (EWs) who were resident in the Russian Federation (RF) for the period from 1986 to the end of 1993. The system of collection and verification of data on leukaemia is described. 48 cases of leukaemia among EWs were identified in 1986 - 1993. The principal analysis includes 34 leukaemia cases occurring more than two years after first exposure. The analysis was carried out for all leukaemia and leukaemia excluding chronic lymphocytic leukaemia (CLL), separately. Distributions of leukaemia cases by age, time of diagnosis since entry into the Chernobyl zone, radiation dose, date of entry into the Chernobyl zone, duration of stay in the region of Chernobyl were calculated. To evaluate leukaemia risks associated with various factors the case - control methodology was used. Radiation dose, date of entry into the zone, duration of stay in the zone were used as risk factors. No significant associations between leukaemia risks and the investigated factors were found. Calculation of the standardised registration ratios (SRR) revealed a significant increase in the registration of leukaemia among all EWs (SRR = 205, 95% confidence interval (CI) 136 - 297) and the EWs arriving in the zone during 1986 - 1987 (SRR = 200, 95% CI: 127 - 300) compared with the general male population of the RF in 1991 - 1993. However, raised SRRs may be accounted for by the differences in medical screening in the compared populations, particularly the efforts made to identify leukaemia cases among the EWs. The absence of a dose-related trend for leukaemia indicates that this explanation is likely to be correct.
A peptide mimetic of tyrosine phosphatase STEP as a potential therapeutic agent for treatment of cerebral ischemic stroke (2017)

Extensive research over the last two decades has advanced our understanding of the pathophysiology of ischemic stroke. However, current pharmacologic therapies are still limited to rapid reperfusion using thrombolytic agents, and neuroprotective approaches that can reduce the consequences of ischemic and reperfusion injury, are still not available. To bridge this gap, we have evaluated the long-term efficacy and therapeutic time window of a novel peptide-based neuroprotectant TAT-STEP, derived from the brain-enriched and neuron-specific tyrosine phosphatase STEP. Using a rat model of transient middle cerebral artery occlusion (90 min), we show that a single intravenous administration of the peptide at the onset of reperfusion (early) or 6 h after the onset of the insult (delayed) reduces mortality rate. In the surviving rats, MRI scans of the brain at days 1, 14 and 28 after the insult show significant reduction in infarct size and improvement of structural integrity within the infarcted area following peptide treatment, regardless of the time of administration. Behavioral assessments show significant improvement in normal gait, motor coordination, sensory motor function and spatial memory following early or delayed peptide treatment. The study establishes for the first time the therapeutic potential of a tyrosine phosphatase in ischemic brain injury.
Confocal Raman Microspectroscopy: The Measurement of VX Depth Profiles in Hairless Guinea Pig Skin and the Evaluation of RSDL (2015)

Abstract : VX depth profiles were obtained using a confocal Raman microspectrometer (River Diagnostics) with a specially designed microscope objective to focus low power laser light into the skin. Noninvasively and in real-time, the scattered light was collected to a depth of about 100 m with an axial resolution of approximately 4 m. The objectives of this study were to use confocal Raman microspectroscopy to investigate the fate of percutaneously applied VX in the upper skin layers of hairless guinea pigs and to determine the ability of Reactive Skin Decontamination Lotion (RSDL) to remove or degrade VX from the skin surface and from any depots forming below the skin surface. VX was observed to remain in the stratum corneum, 0-20 m deep, at about 10-20 minutes postexposure. This postexposure VX concentration in this stratum corneum depot decreased with time but was still detectable at 48 hr postexposure. RSDL was observed to remove or degrade VX from both the skin surface and the depot below the skin surface. Our conclusions are that confocal Raman microspectroscopy is an effective tool to obtain real-time, non-invasive analytical data on the concentration of chemicals in the upper skin layers and that RSDL effectively removes or degrades VX from the skin surface and from the depot formed in the upper skin layers following percutaneous exposure.
ChemInform Abstract: Oxidation and Nitrosation of 4‐(3‐Alkylureido)‐2,2,6,6‐ tetramethylpiperidine 1‐Oxyls (I) to 4‐(3‐Alkyl‐3‐nitrosoureido)‐2,2,6, 6‐tetramethyl‐1‐oxopiperidinium Salts (II), (III). (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
In Vitro Study of Flow Regulation for Pulmonary Insufficiency (2006)

Given the tolerance of the right heart circulation to mild regurgitation and gradient, we study the potential of using motionless devices to regulate the pulmonary circulation. In addition, we document the flow performance of two mechanical valves. A motionless diode, a nozzle, a mechanical bileaflet valve, and a tilting disk valve were tested in a pulmonary mock circulatory system over the normal human range of pulmonary vascular resistance (PVR). For the mechanical valves, regurgitant fractions (RFs) and transvalvular pressure gradients were found to be weak functions of PVR. On the low end of normal PVR, the bileaflet and tilting disk valves fluttered and would not fully close. Despite this anomaly, the regurgitant fraction of either valve did not change significantly. The values for RF and transvalvular gradient measured varied from 4 to 7% and 4 to 7 mm Hg, respectively, at 5 lpm for all tests. The diode valve was able to regulate flow with mild regurgitant fraction and trivial gradient but with values higher than either mechanical valve tested. Regurgitant fraction ranged from 2 to 17% in tests extending from PVR values of 1 to 4.5 mm Hg/lpm at 5 lpm and with concomitant increases in gradient up to 17 mm Hg. The regurgitant fraction for the nozzle increased from 2 to 23% over the range of PVR with gradients increasing to 18 mm Hg. The significant findings were: (1) the mechanical valves controlled regurgitation at normal physiological cardiac output and PVR even though they failed to close at some normal values of PVR and showed leaflet flutter; and (2) it may be possible to regulate the pulmonary circulation to tolerable levels using a motionless pulmonary valve device.
Autologous Bone Marrow-Derived Mesenchymal Stem Cells Modulate Molecular Markers of Inflammation in Dogs with Cruciate Ligament Rupture (2016)

Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog is an important model for human anterior cruciate ligament (ACL) rupture, where rupture of graft repair or the contralateral ACL is also common. This suggests that both genetic and environmental factors may increase ligament rupture risk. We investigated use of bone marrow-derived mesenchymal stem cells (BM-MSCs) to reduce systemic and stifle joint inflammatory responses in dogs with CR. Twelve dogs with unilateral CR and contralateral stable partial CR were enrolled prospectively. BM-MSCs were collected during surgical treatment of the unstable CR stifle and culture-expanded. BM-MSCs were subsequently injected at a dose of 2x106 BM-MSCs/kg intravenously and 5x106 BM-MSCs by intra-articular injection of the partial CR stifle. Blood (entry, 4 and 8 weeks) and stifle synovial fluid (entry and 8 weeks) were obtained after BM-MSC injection. No adverse events after BM-MSC treatment were detected. Circulating CD8+ T lymphocytes were lower after BM-MSC injection. Serum C-reactive protein (CRP) was decreased at 4 weeks and serum CXCL8 was increased at 8 weeks. Synovial CRP in the complete CR stifle was decreased at 8 weeks. Synovial IFNγ was also lower in both stifles after BM-MSC injection. Synovial/serum CRP ratio at diagnosis in the partial CR stifle was significantly correlated with development of a second CR. Systemic and intra-articular injection of autologous BM-MSCs in dogs with partial CR suppresses systemic and stifle joint inflammation, including CRP concentrations. Intra-articular injection of autologous BM-MSCs had profound effects on the correlation and conditional dependencies of cytokines using causal networks. Such treatment effects could ameliorate risk of a second CR by modifying the stifle joint inflammatory response associated with cranial cruciate ligament matrix degeneration or damage.
Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding (2015)

Toxin-antitoxin (TA) modules are pairs of genes essential for bacterial regulation upon environmental stresses. The mazEF module encodes the MazF toxin and its cognate MazE antitoxin. The highly dynamic MazE possesses an N-terminal DNA binding domain through which it can negatively regulate its own promoter. Despite being one of the first TA systems studied, transcriptional regulation of Escherichia coli mazEF remains poorly understood. This paper presents the solution structure of C-terminal truncated E. coli MazE and a MazE-DNA model with a DNA palindrome sequence ∼ 10 bp upstream of the mazEF promoter. The work has led to a transcription regulator-DNA model, which has remained elusive thus far in the E. coli toxin-antitoxin family. Multiple complementary techniques including NMR, SAXS and ITC show that the long intrinsically disordered C-termini in MazE, required for MazF neutralization, does not affect the interactions between the antitoxin and its operator. Rather, the MazE C-terminus plays an important role in the MazF binding, which was found to increase the MazE affinity for the palindromic single site operator.
ChemInform Abstract: Novel Fused‐Ring 1,4‐Benzodiazepines: Synthesis of (1,4)Oxathiano‐(5,6‐b)(1,4)benzodiazepin‐2‐ones. (1988)

Abstract Cyclocondensation reaction of the hydroxybenzodiazepinone (I) with the α‐mercapto acids (II) yields the oxathianones (III) which are methylated with methanol (IV), giving the N‐methyl derivatives (V).
Forensic Investigation of a Wide Culvert Reconstruction Failure (2019)

A growing number of large culverts in the national transportation network are in poor condition. Often, aging infrastructures carry heavy traffic through urban corridors. Either after failure or for replacement, reconstruction must occur rapidly to minimize service disruption. In some cases, new materials are used and uncommon construction practice is followed. The I-88 culvert crossing of Carrs Creek in Sidney, New York completely collapsed during record flooding. Rapid construction using expanded polystyrene (EPS) geofoam blocks as lightweight fill enabled partial reopening of I-88 in less than 3 months of closure. Shortly after reopening of the roadway, rapid and continuing settlements became evident. The roadway was again rebuilt using lightweight aggregates as structural fill above the culvert following complete removal of the geofoam blocks. This investigation of the rapid construction failure reexamines the findings and recommendations of a prior study of the failure. Alternative conclusions and suggestions for improving rapid construction practice with geofoam are presented utilizing the I-88 failure as an example in retrospect.
How to Perform miRacles: A Step‐by‐Step microRNA Detection Protocol Using DNA Nanoswitches (2020)

MicroRNAs are short non-coding RNAs involved in post-transcriptional gene regulation, and are increasingly considered to be biomarkers for numerous biological processes and human diseases. Current techniques used for microRNA detection can be expensive and labor-intensive, and typically require amplification, labeling, or radioactive probes. In this protocol, we describe a DNA nanoswitch-based microRNA detection assay termed "miRacles": microRNA-activated conditional looping of engineered switches. This method uses conformationally responsive DNA nanoswitches that detect the presence of specific microRNAs with a simple and unambiguous gel-shift assay that can be performed on the benchtop. The assay is low cost, minimalistic, and capable of direct detection of specific microRNAs in unprocessed total RNA samples, with no enzymatic amplification, labeling, or special equipment. The protocol for detection of microRNAs in total RNA can be completed in as little as a few hours, making this assay a compelling alternative to qPCR and Northern blotting. © 2020 by John Wiley & Sons, Inc. Basic Protocol 1: Preparation of DNA nanoswitches Basic Protocol 2: Detection of microRNAs from total RNA samples Support Protocol 1: Optional nanoswitch purification by PEG precipitation Support Protocol 2: Optional nanoswitch purification by liquid chromatography.
Skeletal Shape Abstraction from Examples (2008)

Learning a class prototype from a set of exemplars is an important challenge facing researchers in object categorization. Although the problem is receiving growing interest, most approaches assume a one-to-one correspondence among local features, restricting their ability to learn true abstractions of a shape. In this paper, we present a new technique for learning an abstract shape prototype from a set of exemplars whose features are in many-to-many correspondence. Focusing on the domain of 2D shape, we represent a silhouette as a medial axis graph whose nodes correspond to "parts" defined by medial branches and whose edges connect adjacent parts. Given a pair of medial axis graphs, we establish a many-to-many correspondence between their nodes to find correspondences among articulating parts. Based on these correspondences, we recover the abstracted medial axis graph along with the positional and radial attributes associated with its nodes. We evaluate the abstracted prototypes in the context of a recognition task.
Radiation-Curable Adhesives and Coatings (1999)

Radiation curing is the use of electron beam (EB) or ultraviolet (UV) radiation as an energy 
source to induce the rapid conversion of specially formulated 100% polyurethane reactive 
liquids to solids. These specially formulated polyurethanes can be coatings, inks, adhesives, sealants, or potting compounds. In the case of adhesives and sealants, the desired 
conversion may be from a liquid to a semisolid.
Understanding How People Use Natural Language to Ask for Recommendations: Query Dataset (2016)

This dataset describes subjects' initial and follow-up queries from the research paper "Understanding How People Use Natural Language to Ask for Recommendations", published in the ACM Conference on Recommender Systems (RecSys), 2017. The data were collected on movielens.org between May 12 and May 24, 2016.
Toward a full understanding of the growth dynamics, optical response, and crystalline structure of self-assembled photonic colloidal crystal films (2010)

Recent advances in the comprehension of the growth dynamics of colloidal crystal films opens the door to conscious design of experiments aiming at fabricating lattices in which the density of intrinsic defects is minimized. Since such imperfections have a dramatic effect on scattered light of wavelength smaller than the lattice constant, the evaluation of the experimental optical response at those energy ranges, based on the comparison to rigorous calculations, is identified as the most sensitive guide to accurately evaluate the progress towards the actual realization of defect free colloidal crystals. The importance of the existence of a certain distortion becomes particularly relevant at the above mentioned energy range. We have thoroughly analyzed the effect of fine structural features on the optical response to conclude that, rather than the generally assumed FCC lattice of spheres, opal films are better approximated by a rhombohedral assembly of distorted colloids. Interparticle distance of actual colloidal crystals coincides with the expected diameter for spheres belonging to the same close-packed (111) plane but differs significantly in directions oblique to the [111] one.
IDENTIFICATION OF THRESHOLD LEVELS FOR WARNER‐BRATZLER SHEAR FORCE IN BEEF TOP LOIN STEAKS (1991)

ABSTRACT Threshold Warner‐Bratzler shear (WBS) values were determined by regression analysis of WBS force values and trained sensory panel overall tenderness ratings of beef top loin steaks from A‐ and B‐maturity carcasses (n = 678). Guidelines for retail and foodservice beef were based on 50 and 68% confidence levels, respectively, for overall tenderness ratings of “slightly tender.” Due to the extreme variation in tenderness that exists in the current U.S. beef population, more stringent confidence levels were not practical. Threshold WBS values for retail and foodservice beef were 4.6 and 3.9 kg, respectively. When these values were tested against the population of beef in the National Consumer Retail Beef Study, the 4.6 kg value was 88.6% accurate at determining whether or not a steak would be rated less than “slightly tender”by consumers.
Charge state dependence of channeled ion energy loss (1981)

The charge state dependence of channeled ion energy loss has been determined for a series of ions ranging from fluorine to chlorine along the $〈110〉$ direction in a silicon crystal. Energy losses for both bare ions and ions partially clothed with bound electrons at $\frac{E}{A}\ensuremath{\cong}3$ MeV/amu have been measured. The energy-loss rate for bare ions follows a strict ${Z}_{1}^{2}$ scaling and agrees reasonably well with quantal perturbation calculations without the need for polarization or Bloch corrections. An explanation for this result is discussed. The clothed-ion energy losses appear to demonstrate screening effects that agree qualitatively with simple estimates. The angular dependence of the observed energy-loss effects is also presented.
Mise au point d'une méthodologie de synthèse de filtres hyperfréquences à pertes d'insertion minimales (2009)

National audience
Snapping Wrist due to an Anomalous Extensor Indicis Proprius: A Case Report (2008)

Variation in the extensor muscles of the hand is common. These anatomic deviations are rarely symptomatic. We report a unique case of an anomalous extensor indicis proprius causing a painful snapping wrist. Intraoperative examination revealed a disproportionately large muscle belly under the extensor retinaculum causing subluxation of the ring and small extensor tendons creating a painful snapping phenomenon. Following excision, the subluxation and pain resolved.
The Electrolytic Preparation of Periodate Oxystarch (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Electrolytic Preparation of Periodate OxystarchWilliam Dvonch and C. L. MehltretterCite this: J. Am. Chem. Soc. 1952, 74, 21, 5522–5523Publication Date (Print):November 1, 1952Publication History Published online1 May 2002Published inissue 1 November 1952https://pubs.acs.org/doi/10.1021/ja01141a511https://doi.org/10.1021/ja01141a511research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Holographic formation of gratings in optical waveguiding layers (1975)

Thick phase gratings were formed photorefractively (through optically induced refractive index changes) in planar optical waveguides by intersecting short−wavelength coherent guided beams. In multimode guides formed by effusing Li from LiNbO3, maximum diffraction efficiencies were 52% at the 0.488−μm write wavelength and 3.1% at 0.633 μm. In a two−mode LiTa1−xNbxO3 guide formed by diffusing Nb into LiTaO3 at 1100 °C, diffraction efficiencies were 65% and 28% at the same two wavelengths, respectively.
Environmental degradation of engineering materials in aggressive environments (1981)

This book is one volume of the proceedings of the second conference on Environmental Degradation of Engineering Materials held at Virginia Polytechnic Institute on September 21-23, 1981. Papers in this volume describe fatigue and corrosion fatigue, liquid metal embrittlement, nuclear environment effects, degradation of composites and polymers, stress corrosion cracking and both analytical and experimental attempts to simulate or model the process of degradation. The other volume of the proceedings Environmental Degradation of Engineering Materials in Hydrogen contains papers which describe hydrogen uptake and transport by metals, hydrogen adsorption and evolution from metals and hydrogen embrittlement of metals. Forty-two papers have been abstracted and indexed for the Energy Data Base.
ChemInform Abstract: Cyclodimerization of Indol‐2‐ylacetylenes. An Example of Intermolecular Enyne—Alkyne Cycloaddition. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.