gebhart/patrepeval huggingface dataset:
Isolation and Sequence Analysis of Bovine α<sub>sl</sub>-Casein cDNA Clone (1984)

Journal Article Isolation and Sequence Analysis of Bovine αsl-Casein cDNA Clone Get access Masaya Nagao, Masaya Nagao Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Masatoshi Maki, Masatoshi Maki Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Ryuzo Sasaki, Ryuzo Sasaki Search for other works by this author on: Oxford Academic Google Scholar Hideo Chiba Hideo Chiba Department of Food Science and Technology, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 48, Issue 6, 1 June 1984, Pages 1663–1667, https://doi.org/10.1080/00021369.1984.10866378 Published: 01 June 1984 Article history Received: 06 February 1984 Published: 01 June 1984
Structure of Tomatillidine (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of TomatillidineEnnio Bianchi, Carl Djerassi, Herbert Budzikiewicz, and Yoshio SatoCite this: J. Org. Chem. 1965, 30, 3, 754–760Publication Date (Print):March 1, 1965Publication History Published online1 May 2002Published inissue 1 March 1965https://pubs.acs.org/doi/10.1021/jo01014a024https://doi.org/10.1021/jo01014a024research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FAK-mediated extracellular signals are essential for interkinetic nuclear migration and planar divisions in the neuroepithelium (2010)

During the development of the vertebrate nervous system, mitosis of neural progenitor cells takes place near the lumen, the apical side of the neural tube, through a characteristic movement of nuclei known as interkinetic nuclear migration (INM). Furthermore, during the proliferative period, neural progenitor cells exhibit planar cell divisions to produce equivalent daughter cells. Here, we examine the potential role of extracellular signals in INM and planar divisions using the medaka mutant tacobo (tab). This tab mutant shows pleiotropic phenotypes, including neurogenesis, and positional cloning identified tab as laminin gamma1 (lamc1), providing a unique framework to study the role of extracellular signals in neurogenesis. In tab mutant neural tubes, a number of nuclei exhibit abnormal patterns of migration leading to basally mislocalized mitosis. Furthermore, the orientation of cell division near the apical surface is randomized. Probably because of these defects, neurogenesis is accelerated in the tab neural tube. Detailed analyses demonstrate that extracellular signals mediated by the FAK pathway regulate INM and planar divisions in the neuroepithelium, possibly through interaction with the intracellular dynein-motor system.
The microbiome and IL-10 are critical factors in regulating the number of marginal zone B cells (P1086) (2013)

Abstract Marginal zone (MZ) B cell positioning within the spleen allows them to rapidly respond to blood-borne pathogens. Very little is known regarding how MZ B cell homeostasis is controlled. We found a critical role for IL-10 and the microbiome in regulating MZ B cell numbers. Specifically, IL-10-/- mice obtained from Jackson Lab (JAX) but maintained in our colony exhibited a significant increase in the absolute number of MZ B cells. However, mice from JAX had normal numbers of MZ B cells. When we co-housed IL-10-/- JAX mice with our IL-10-/- mice, MZ B cell numbers were significantly increased. These results suggested that the microbiome plays a prominent role in regulating MZ B cell homeostasis. To confirm this, we treated IL-10-/- JAX mice with broad-spectrum antibiotics during the co-housing period and were able to prevent the increase in MZ B cell numbers. In addition, the treatment of our IL-10-/- mice with antibiotics was sufficient to reverse the increase in MZ B cells. One major difference between the two sources of mice is that ours are colonized with helicobacter, a contributing factor to inflammation and colitis. We found that specific colonization of JAX IL-10-/- mice with helicobacter was sufficient to increase MZ B cell numbers. Thus we have uncovered that IL-10 controls a regulatory loop whereby specific bacteria in the gut capable of inducing inflammation drive an increase in MZ B cells that would be beneficial should a breach in the gut result in sepsis.
Spectral quality during pod development modulates soybean seed fatty acid desaturation (1993)

ABSTRACT High‐density cropping of soybeans results in considerable mutual shading. Consequently, pods mature under a range of light conditions, with those lower in the canopy exposed to drastically altered spectral quality as well as lower irradiance. The influence of spectral quality on reproductive development and seed quality was investigated in soybeans raised to physiological maturity under either broad spectrum or blue‐deficient light sources. The absence of blue light had a large influence on vegetative morphology, but the timing of reproductive events was not affected. Total seed yield per plant, dry matter per seed, per cent protein and per cent oil were similar for all treatments. However, seeds harvested from plants matured under broad spectrum illumination contained high levels of oleic acid (18:1) and low linoleic acid (18:2) compared to seeds from plants grown under blue‐deficient conditions. In addition to the spectral quality effect, there was a smaller effect of pod position. Seeds from pods lower in the canopy contained less 18:1 and more 18:2 than seeds that matured closer to the top of the canopy. Considering both spectral quality and pod position, the ratio of 18:1 to 18:2 varied four‐fold between 0·35 and 1·43, indicative of a possible photoregulatory step in fatty acid desaturation. The spectral effects are consistent with the participation of a photomorphogenetic photoreceptor in the control of fatty acid metabolism during seed maturation and triglyceride accumulation.
Graft Fixation Alternatives (2005)

Summary: Stable graft fixation is critical to successful ACL reconstruction. Graft migration must be prevented during the 6 to 12-week postoperative period that is required for graft-tunnel incorporation. Maximizing interference screw fixation, avoiding pitfalls of screw insertion, managing graft-tunnel mismatch, and alternative fixation techniques are discussed.
Vigor of Movements and the Cost of Time in Decision Making (2014)

If we assume that the purpose of a movement is to acquire a rewarding state, the duration of the movement carries a cost because it delays acquisition of reward. For some people, passage of time carries a greater cost, as evidenced by how long they are willing to wait for a rewarding outcome. These steep discounters are considered impulsive. Is there a relationship between cost of time in decision making and cost of time in control of movements? Our theory predicts that people who are more impulsive should in general move faster than subjects who are less impulsive. To test our idea, we considered elementary voluntary movements: saccades of the eye. We found that in humans, saccadic vigor, assessed using velocity as a function of amplitude, was as much as 50% greater in one subject than another; that is, some people consistently moved their eyes with high vigor. We measured the cost of time in a decision-making task in which the same subjects were given a choice between smaller odds of success immediately and better odds if they waited. We measured how long they were willing to wait to obtain the better odds and how much they increased their wait period after they failed. We found that people that exhibited greater vigor in their movements tended to have a steep temporal discount function, as evidenced by their waiting patterns in the decision-making task. The cost of time may be shared between decision making and motor control.
Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire. (1991)

The T cell receptor repertoire has a potential for vast diversity. However, this diversity is limited by the fact that the majority of thymocytes die as the repertoire is shaped by positive and negative selection events during development. Such thymic selection affecting TCR V beta gene segment usage has been demonstrated in the mouse. However, similar data has not been forthcoming in man, and little is known about the role of the TCR alpha chain in antigen/major histocompatibility complex (MHC) recognition in any species. Here, we used a monoclonal antibody recognizing the TCR V alpha 12.1 gene product to assess the expression of this gene in the peripheral blood of man. In most individuals tested, the percentage of cells expressing V alpha 12.1 was significantly higher in CD8+ T cells than in CD4+ T cells. That the V alpha gene product itself was responsible for this increased expression in CD8+ T cells was underscored by the lack of substantial skewing of V beta usage in the V alpha 12.1-bearing T cells. Moreover, the skewed expression of V alpha 12.1 was already present at birth, indicating that it was likely to be due to a developmental process rather than the result of exposure to environmental antigens. Based on the established role for CD8 in binding to class I MHC molecules, we suggest that increased expression of V alpha 12.1 on CD8+ T cells points to a role for TCR's using V alpha 12.1 in class I MHC/Ag recognition. These results indicate that V alpha gene usage in the peripheral blood of man is not random, and they support a role for V alpha as a participant in the self-MHC recognition process that shapes the TCR repertoire.
The Effect of Demolding Temperature on Aging Behavior in Al-10%Si-Mg System Alloys Cast by Sand Mold (2016)

The aging behavior of Al-10%Si-Mg system alloys cast into sand mold were investigated by optical microscopy, scanning electron microscopy and micro-vickers hardness measurement. The castings were demolded and water-quenched at 323, 473, 573, 673 and 773K after cast, and then those were artificial aged at 423, 473 and 523 K. With increasing Mg content from 0.3 % to 0.9 %, the agehardenability (ΔHV: difference of hardness between as-cast and peak-aged condition) was increased relatively gradually, because the solid solubility of Mg and Si in the matrix was decreased due to the crystallization of π-Fe and Mg2Si phases. The ΔHV of sand mold castings was larger than that of permanent mold castings when the demolded temperatures were 673 K and 773 K. This is due to the difference in the amount of precipitates, which were attributed from passing time at high temperature range above solvus line of metastable Mg2Si phase.
THE SPECIFIC FREE RADICAL SCAVENGER EDARAVONE SUPPRESSES BLEOMYCIN‐INDUCED ACUTE PULMONARY INJURY IN RABBITS (2006)

1 Intratracheal instillation of bleomycin induces a condition in rabbits that serves as a useful model of human pulmonary fibrosis. Bleomycin-induced production of reactive oxygen species leads to acute lung inflammation and induction of apoptosis, which is followed by pulmonary fibrosis at a later chronic stage. In the present study, we tested whether edaravone, a free radical scavenger, would suppress bleomycin-induced acute pulmonary inflammation. 2 Rabbits were divided into three groups (n = 10 in each): (i) a bleomycin-treated group, which received intratracheal instillation of 2 mg/kg bleomycin; (ii) a bleomycin + edaravone group, which received a 10 day regimen of daily intravenous injections of edaravone (3 mg/kg per day) beginning 3 days before bleomycin instillation; and (iii) a saline control group. Rabbits were killed for analysis 7 days after bleomycin administration. 3 In lung tissues from the bleomycin-treated group, marked infiltration of inflammatory cells, consisting mainly of lymphocytes, neutrophils and eosinophils, was observed. In addition, significantly increased numbers of TUNEL-positive (apoptotic) and transforming growth factor-β-positive cells were seen. All these effects were significantly attenuated by treatment with edaravone. 4 The findings of the present study suggest that edaravone may be useful in the prevention of acute lung injury resulting from the production of reactive oxygen species.
Predicting treatment outcomes in CLL (2014)

In this issue of Blood , Stilgenbauer and colleagues report on the prognostic and predictive value of gene mutations assessed prospectively in patients with chronic lymphocytic leukemia (CLL) treated with first-line chemoimmunotherapy.[1][1]

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[McDonald, James Ingram] 1865-1935 :Thomas Brunner, the explorer. [ca 1926] (1920)

Head and shoulders portrait of Brunner in middle age, dressed in a suit 
Based on an earlier photograph, ca 1870? 
Note on mount: Early New Zealand. 
Quantity: 1 watercolour(s). 
Physical Description: Watercolour 175 x 88 mm
Focus: Landmarks: Powerful Pictures (2009)

Richard Feynman invented the cartoon-like pictures of particle interactions that are essential to particle physicists and published the first one in 1949.
Combined local chemotherapy for a spontaneously occurring intraocular tumour in a cat. (1983)

A spontaneously occurring tumour in the anterior chamber of the eye of a cat was diagnosed by aspiration needle biopsy as a malignant lymphosarcoma. Combined local chemotherapy, consisting of subconjunctival injection of methylprednisolone acetate and methotrexate along with topical administration of dexamethasone, led to rapid resolution of the lesion. Over 18 weeks of follow-up there was no recurrence.
Ni-Cu-Re合金自生氧化膜的减摩机理 (1990)

用旋转式高温销盘摩擦试验机测定了 Ni、Ni-Re,Ni-Cu、Cu-Re 及 Ni-Cu-Re 等合金摩擦系数随温度的变化;用 X 射线测定了磨屑及氧化层、Ni-Cu-Re 550℃的挥发物结构;能谱测定了磨屑、氧化膜及近表层成分,还进行了静态氧化实验,试验发现高温摩擦实验后样品近表层有富 Re 层,它不利于氧化膜的形成,但降低了合金的氧化速度,提高了耐磨性,试验结果还表明了Ni-Cu-Re 系高温摩擦系数较低(0.2-0.3),原因是 Cu,Re 共同作用形成易挥发性氧化物起的润滑作用,提出了氧化膜的减摩模型。
Biomaterials from Marine‐Origin Biopolymers (2012)

This chapter contains sections titled: Taking Inspiration from the Sea Marine-Origin Biopolymers Marine-Based Tissue Engineering Approaches Conclusions References
Optical micro-machined ultrasound sensors with a silicon photonic resonator in a buckled acoustical membrane (2019)

Future applications of ultrasonography in (bio-)medical imaging require ultrasound sensor matrices with small sensitive elements. Promising are opto-mechanical ultrasound sensors (OMUS) based on a silicon photonic ring resonator embedded in a silicon-dioxide acoustical membrane. This work presents new OMUS modelling: acousto-mechanical non-linear FEM and photonic circuit equations. We show that initial wafer stress needs to be considered in the design: the acoustical resonance frequency changes considerably and OMUS sensitivity differs for up-or downwards buckled membranes. Simulated acoustical resonance frequency agrees well with measurements, assuming realistic SOI wafer stress. Measured sensitivity showed large device-to-device variation and simulations agree within this order of magnitude. We conclude that careful modeling of stress is necessary (b) for the design of robust and sensitive sensors.
A Novel Semiblind Signal Extraction Approach for the Removal of Eye-Blink Artifact from EEGs (2008)

A novel blind signal extraction (BSE) scheme for the removal of eye-blink artifact from electroencephalogram (EEG) signals is proposed. In this method, in order to remove the artifact, the source extraction algorithm is provided with an estimation of the column of the mixing matrix corresponding to the point source eye-blink artifact. The eye-blink source is first extracted and then cleaned, artifact-removed EEGs are subsequently reconstructed by a deflation method. The a priori knowledge, namely, the vector, corresponding to the spatial distribution of the eye-blink factor, is identified by fitting a space-time-frequency (STF) model to the EEG measurements using the parallel factor (PARAFAC) analysis method. Hence, we call the BSE approach semiblind signal extraction (SBSE). This approach introduces the possibility of incorporating PARAFAC within the blind source extraction framework for single trial EEG processing applications and the respected formulations. Moreover, aiming at extracting the eye-blink artifact, it exploits the spatial as well as temporal prior information during the extraction procedure. Experiments on synthetic data and real EEG measurements confirm that the proposed algorithm effectively identifies and removes the eye-blink artifact from raw EEG measurements.
Drain-Source Symmetric Artificial Neural Network-Based FET Model with Robust Extrapolation Beyond Training Data (2007)

A large-signal FET model based on artificial neural networks (ANNs) is extended for rigorous intrinsic drain-source symmetry and robust extrapolation beyond the range of training data. Enhanced ANN architectures and training algorithms constrain the five nonlinear model state functions to transform according to the discrete symmetry rules related to the device invariance with respect to intrinsic drain-source exchange. This extends the applicability of the previous ANN-based model to situations where the instantaneous voltage crosses V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ds</sub> = 0, such as switches and mixers. The model is compiled in Agilent ADS, together with advanced extrapolation routines extending the model beyond the range of training data for improved convergence. The model has been generated for FETs from several III-V semiconductor processes, and validated with extensive independent small and large-signal measurements.
Electrophysiological evidence for rapid 5-HT1A autoreceptor inhibition by vilazodone, a 5-HT1A receptor partial agonist and 5-HT reuptake inhibitor (2013)

This study examined the effect of vilazodone, a combined serotonin (5-HT) reuptake inhibitor and 5-HT(1A) receptor partial agonist, paroxetine and fluoxetine on the sensitivity of 5-HT(1A) autoreceptors of serotonergic dorsal raphe nucleus neurons in rats. These effects were assessed by determining the intravenous dose of (±)-8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) required to suppress the basal firing rate of these neurons by 50% (ID₅₀) in anesthetized rats using in vivo electrophysiology. 5-HT uptake inhibition was determined by the ability of the compounds to reverse (±)-p-chloroamphetamine (PCA)-induced rat hypothalamic 5-HT depletion ex vivo. Acute vilazodone administration (0.63 and 2.1 µmol/kg, s.c.), compared with vehicle, significantly increased (2-3-fold) the ID₅₀ of 8-OH-DPAT at 4 h, but not 24h after administration. Subchronic administration (3 days) significantly increased the ID₅₀ value at 4 h (3-4-fold) and at 24 h (~2-fold). In contrast, paroxetine and fluoxetine at doses that were supramaximal for 5-HT uptake inhibition did not significantly alter the ID₅₀ value of 8-OH-DPAT after acute or subchronic administration. Vilazodone antagonized the action of PCA 3.5 h and 5 h after a single dose (ID₅₀ 1.49 and 0.46 µmol/kg, s.c., respectively), but was inactive 18 h post-administration, corroborating the electrophysiological results at 24 h following acute administration. The results are consistent with the concept of rapid and, following repeated treatment, prolonged inhibition of 5-HT(1A) autoreceptors by vilazodone. This effect could occur by either direct interaction with, or desensitization of, these receptors, an effect which cannot be ascribed to vilazodone's 5-HT reuptake inhibiting properties.
The Industrial Research Chemist (1950)

RETURN TO ISSUEPREVNewsNEXTThe Industrial Research ChemistThe industrial research man must be in love with his work and with his company . . . He must have the dogged patience to delve deep and come up with concrete, well expressed interpretations of the one to the other . . . Manual dexterity and the willingness to shoulder responsibility round out the character deemed essential to a good researcher in industryCARROLL A. HOCHWALT and NICHOLAS N. T. SAMARASView Author Information Monsanto Chemical Co.Cite this: Chem. Eng. News 1950, 28, 39, 3296–3298Publication Date (Print):September 25, 1950Publication History Published online5 November 2010Published inissue 25 September 1950https://pubs.acs.org/doi/10.1021/cen-v028n039.p3296https://doi.org/10.1021/cen-v028n039.p3296newsACS PublicationsCopyright © 1950 AMERICAN CHEMICAL SOCIETYArticle Views4Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Stimulated Raman scattering by an intense relativistic electron beam in a long rippled magnetic field (1977)

For the first time, the parametric coupling of the negative-energy cyclotron and space-charge modes to a fast coaxial waveguide structure is observed. The coaxial waveguide smooth center conductor is internally loaded to maintain a 5% ripple of 1.4-, 1.6-, or 2.0-cm periods on the background axial magnetic field throughout the interaction region of 70 cm. The parametric coupling may be considered a stimulated scattering process with the rippled magnetic field of zero frequency in the lab frame appearing as an electromagnetic pump wave in the beam frame, with 30-MW/${\mathrm{cm}}^{2}$ power density imparting to the electrons a quiver velocity ${V}_{\mathrm{os}}\ensuremath{\simeq}0.1c$. As predicted by theory, the frequency of the microwave radiation generated by the negative-energy cyclotron mode decreases with increasing magnetic field while remaining constant for the negative-energy space-charge mode. Power levels from 1 to 5 MW have been measured at mm and cm wavelengths. Radiation at frequencies of $\frac{2{\ensuremath{\gamma}}^{2}V}{L}$, where $V$ and $L$ are the beam velocity and ripple period, respectively, has been observed at high magnetic fields with an exponential-growth rate consistent with parametric coupling theory. This mechanism could be employed as a tunable generator of millimeter and submillimeter wavelength radiation.