gebhart/patrepeval huggingface dataset:
Rescuing 3T3-L1 Adipocytes from Insulin Resistance Induced by Stimulation of Akt-Mammalian Target of Rapamycin/p70 S6 Kinase (S6K1) Pathway and Serine Phosphorylation of Insulin Receptor Substrate-1: Effect of Reduced Expression of p85α Subunit of Phosphatidylinositol 3-Kinase and S6K1 Kinase (2008)

Phosphorylation of insulin receptor substrate-1 (IRS-1) on serine residues has been recognized as a mechanism responsible for a diminution of insulin action and insulin resistance. Potential approaches to improve insulin sensitivity may include interference with and/or reduction in expression of certain signaling intermediates that participate in the pathogenesis of insulin resistance. In this study, we transduced fully differentiated 3T3-L1 adipocytes with a constitutively active myristoylated Akt that led to hyperactivation of mammalian target of rapamycin and p70 S6 kinase (S6K1), increased serine phosphorylation of IRS-1, and reduction in insulin-stimulated phosphatidylinositol (PI) 3-kinase activity and glucose transport. We then reduced expression of the PI 3-kinase regulatory subunit, p85alpha, or expression of S6K1 kinase using small interfering RNA transfections, which led to a reduction in p85alpha expression of 70% at 48 h (P < 0.05) and S6K1 of 49% (P < 0.05). Reduction in expression of either p85alpha or S6K1 achieved with small interfering RNA in the presence of myristoylated Akt rescued 3T3-L1 adipocytes from the insulin resistance induced by serine phosphorylation of IRS-1 and completely restored insulin-stimulated activation of PI 3-kinase and glucose uptake. We conclude that reduction in expression of p85alpha or S6K1 could represent therapeutic targets to mitigate insulin resistance.
Dependence of Natural Rubber Swelling Index upon Organic Solvents Properties (2011)

Mathematic analysis of the data on natural rubber swelling shows the degree of organic solvents penetrating dependence on their ability to nonspecific interaction and cohesion, which counteracts this process.
Measurement and on-line estimation approaches to parameter variation in vector controllers (1993)

A compromise exists in a drive based around a vector-controlled induction motor between the need to obtain reliable control information (for both feedback and parameter identification) and the need to maintain the mechanical ruggedness and cost advantage of the motor. Voltage and current sensors within the power converter are acceptable whereas sensors fixed to the motor are to be avoided. Rotor currents and voltages will be unavailable for cage rotors. Two approaches to this problem are considered. The first is to obtain the maximum information from the sensors available by injecting known, small-amplitude voltages and processing the resulting currents. The second is to use on-line parameter estimation with particular attention to the rotor resistance parameter needed to calculate the magnitude and position of the rotor flux. >
Towards a method of programming with assertions (1992)

Article Free Access Share on Towards a method of programming with assertions Author: David S. Rosenblum View Profile Authors Info & Claims ICSE '92: Proceedings of the 14th international conference on Software engineeringJune 1992 Pages 92–104https://doi.org/10.1145/143062.143098Online:01 June 1992Publication History 40citation1,041DownloadsMetricsTotal Citations40Total Downloads1,041Last 12 Months28Last 6 weeks14 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Key-posture extraction out of human motion data (2005)

Recent progress in 3-D capture technology has made it possible to obtain much of realistic motion data of human subjects. Being captured in high frame rates, compression or extraction of key postures out of the motion data is useful for storage, transfer and browsing among them: this can serve as an Important pre-processing for applications such as rehabilitation, ergonomics and sports physiology. This paper addresses these problems by treating the motion date as trajectory curves In a high-dimensional space and doing a novel application of a curve simplification algorithm, typically used for planar curves, to human motion data.
Highly Efficient RF Transmitter Over Broad Average Power Range Using Multilevel Envelope-Tracking Power Amplifier (2015)

We present a highly efficient RF transmitter over broad average power range using a multilevel envelope-tracking power amplifier (ML-ET PA). The ML-ET PA delivers enhanced efficiency at a back-off power region for handset applications. The supply modulator consists of a linear regulator and a switching converter. The DC supply of the linear regulator is adjusted according to the average power of the envelope signal, and the power-supply-independent class-AB output stage is employed to avoid the crossover distortion generated by the different DC supply voltages. The switch current level is not optimally adjusted by itself following the power back-off level, because the DC supply voltages of the linear regulator and switching converter are different. For the optimum operation over the entire power region, the switch current level is adjusted by detecting the input envelope voltage level. For a 20-MHz long term evolution signal with a 7.5 dB peak-to-average power ratio, the proposed supply modulator delivers a peak voltage of 4.5 V to a 6.5 Ω load with a measured efficiency of 75.9%. The proposed ET PA delivers a power-added efficiency (PAE) of 40%, gain of 28.8 dB, evolved universal terrestrial radio access adjacent channel leakage ratio of -35.3 dBc, and error vector magnitude of 3.23% at an average output power of 27 dBm and an operating frequency of 1.71-GHz. At a 10 dB back-off point, the PAE is improved from 14.5% to 18.7% compared to the conventional ET PA.
The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma. (1993)

Glutathione S-transferase (GST) enzymes detoxify carcinogens in tobacco smoke. Interindividual variation in GST function may be related to differences in risk for smoking-related cancer. Leukocytes from 50% of Caucasians lack GST activity toward trans-stilbene oxide (TSO), due to a deletion of the gene for the GST-mu enzyme. Presence of GST-TSO activity in leukocytes has been associated with low risk for lung cancer among cigarette smokers. We sought to determine whether GST activity in lung tissue is determined by the same gene polymorphism and whether it is associated with risk for lung cancer. Subjects were cigarette smokers, identified at the time of lung resection or autopsy in Seattle hospitals. Uninvolved lung tissue was obtained from 35 patients with lung carcinoma and 43 control patients and assayed for GST-mu activity with TSO, for the presence of the GST-mu gene product with an immunological assay, and for the GST-mu gene with Southern blotting. Mailed questionnaires were used to collect information on subjects' smoking histories and exposures which might alter enzyme activity. Interindividual results from the three assays correlated well. Smokers with high GST-TSO enzyme activity present in their lung tissue had a lower risk for lung carcinoma than did smokers with no or low activity (relative risk = 0.30; 95% confidence interval, 0.11-0.79), as did smokers with GST-mu antigen identified in lung tissue versus those with no antigen (relative risk = 0.30; 95% confidence interval, 0.11-0.79). Smokers with both maternal and paternal copies of GST-mu DNA (n = 7) had a lower cancer risk than smokers lacking GST-mu DNA (n = 30; relative risk = 0.35; 95% confidence interval, 0.06-2.10). High GST-mu activity appeared to be associated with a greater decrease in lung cancer risk among 38 heavy cigarette smokers (relative risk = 0.15; 95% confidence interval, 0.03-0.64) than among 38 light smokers (relative risk = 0.61; 95% confidence interval, 0.14-2.60). Presence or absence and number of copies of the GST-mu gene appear to determine activity of the GST-mu enzyme in lung. Smokers with the GST-mu enzyme have approximately one-third of the risk for lung carcinoma of smokers without the enzyme.
Inmate Perceptions of Residential Substance Abuse Treatment Programming (2002)

ABSTRACT Drug and alcohol use and abuse are responsible for many social ills, including an association with criminal involvement and repeat offending. The Residential Substance Abuse Treatment (RSAT) program at the South Idaho Correctional Institution (SICI) is designed to fill a need for treatment of substance-abusing parole violators. RSAT program design includes a 9-12 month treatment regimen for chronic substance abusers that addresses addiction and criminality. The intent is to create a structured therapeutic environment with three treatment modalities, including cognitive self-change, behavioral, and 12-step programming. In this paper we present the findings from a questionnaire in which we queried inmates regarding their perceptions of the RSAT programming. We found that those inmates enrolled in the first and/or the third phase of the treatment tended to be more positive in their perceptions of program content, the therapeutic atmosphere and the quality of services provided than were those in the middle, or second phase of treatment. Paradoxically, we also found that there was a negative relationship between those with most months in the program and their perceptions of it while those with the most serious pattern of alcohol abuse tended to perceive the program more positively.
Efficient Simultaneous Tumor Targeting Delivery of All-Trans Retinoid Acid and Paclitaxel Based on Hyaluronic Acid-Based Multifunctional Nanocarrier (2013)

An amphiphilic hyaluronic acid (HA)-g-all-trans retinoid acid (HRA) conjugate was successfully developed as a tumor-targeting nanocarrier for potentially synergistic combination chemotherapy of all-trans retinoid acid (ATRA) and paclitaxel (PTX). The HRA conjugate was synthesized by an imine reaction between HA-COOH and ATRA-NH2. PTX-loaded HRA nanoparticles possessed a high loading capacity, nanoscale particle sizes, and good biocompatible characteristics. Cell viability assays indicated that PTX-loaded HRA nanoparticles exhibited concentration- and time-dependent cytotoxicity. Moreover, they displayed obvious superiority in inducing the apoptosis of tumor cells. Cellular uptake analysis suggested that HRA nanoparticles could be efficiently taken up by cells via endocytic pathway and transport into the nucleus, contributing to HA receptor-mediated endocytosis and ATRA-induced nuclear translocation, respectively. Moreover, in vivo imaging analysis indicated that the accumulation of DiR-loaded HRA nanoparticles in tumor was increased obviously after intravenous administration as compared to free DiR solution, which confirmed that the HRA nanoparticles could assist the drugs targeting to the tumor. Furthermore, PTX-loaded HRA nanoparticles exhibited greater tumor growth inhibition effect in vivo with reducing the toxicity. Therefore, HRA nanoparticles can be considered as a promising targeted codelivery system for combination cancer chemotherapy.
Comparative Analysis of Some Modal Reconstruction Methods of the Shape of the Cornea from Corneal Elevation Data (2009)

The Zernike (and especially, the Bhatia-Wolf) polynomials constitute a reliable reconstruction method of a nonseverely aberrated surface with a small surface regularity index (SRI). However, they fail to capture small deformations of the anterior surface of a synthetic cornea. The most promising approach is a combined one that balances the robustness of the Zernike fit with the localization of the RBF.
Speckle Filtering of PolSAR and PolInSAR Images using Trace-based Partial Differential Equations (2006)

Partial Differential Equations (PDE) filtering methods provide regularization of an image through successive iterations, where pixel values are gradually diffused in accordance with a local diffusion tensor field. The local diffusion tensor field determines the local smoothing geometry that should drive the regularization process. Most diffusion based filtering methods rely on a divergence formulation for the diffusion term which does not produce an optimal geometry preserving regularization. A new trace-based PDE approach was recently proposed and has been applied to the filtering of color images and other multivalued data. Compared to a classical divergence based formulation approach, a trace based formulation better preserves the geometric content of the image. We propose to apply this framework to the filtering of Polarimetric Interferometric Synthetic Aperture Radar (PolInSAR) images. In particular, the calculation of the local geometry is modified in order to be robust to the speckle noise. Speckle reduction performances are evaluated on both artificial and real PolInSAR images and are compared to other standard speckle reduction filters in terms of radiometric resolution improvement and meaningful details preservation.
Methotrexate in the treatment of rheumatoid arthritis. I. In vitro effects on cells of the osteoblast lineage (2002)

At concentrations > or =10 nM, treatment with MTX inhibits the proliferation of primitive marrow stromal cells, but not their ability to undergo osteogenic differentiation. The proliferation and further maturation of cells of the osteoblast lineage is not affected by treatment with MTX. These findings are reassuring for clinicians using MTX in the treatment of RA.
Identifying Lost Surgical Needles Using Radiographic Techniques (2003)

Many surgical procedures involve the use of very small surgical needles. In the event that a postoperative needle count is incorrect, traditionally an x-ray has been taken to find the needle. Little data exist to recommend the smallest surgical needle that can be identified with conventional radiographic techniques and the optimum technique for finding lost surgical needles. In this quality assurance project x-rays of various size surgical needles were taken. The smallest seen by the majority of observers was 17 mm. The radiographic technique of choice for optimum detection of lost surgical needles was imaging with a mobile image intensifier.
A Multivariate Correlation Degradation Model for Reliability Analysis Based on Copula (2020)

Degradation process modeling is an important part of reliability analysis. At present, most researches about it focus on univariate degradation models. The independence assumption is adopted to analyze multivariate degradation indicators. In order to describe the correlation between two or more degradation indicators more accurately, a multivariate correlation degradation model based on copula was proposed to analyze system reliability in this paper. First, the univariate degradation model was established for different degradation process. Then, the cosine similarity measure was used to calculate the overall and local correlations for every two degradation indicators. Combining the cosine similarity values with each copula characteristics, the appropriate copula function was selected to compose Mixed Copula (M-Copula), which could describe the correlation between two degradation indicators well. Based on that, the optimization model with the residual minimization as the objective was constructed and solved to obtain the degradation correlation reliability model. Copula functions with different characteristics are screened by cosine similarity in this method, which could improve the accuracy and efficiency of reliability modeling and life prediction. It could also save cost. Finally, a case was calculated to verify the feasibility and effectiveness.
Characterization of the <i>traT</i> gene and mutants that increase outer membrane permeability from the <i>Salmonella typhimurium</i> virulence plasmid (1990)

The nucleotide sequence of the traT gene present in the virulence-associated plasmid of Salmonella typhimurium was determined. The predicted TraT protein encoded by this gene was found to consist of 243 amino acids and to resemble the known TraT proteins of the plasmids of the F incompatibility group. Thus it contains a signal sequence of 20 amino acids, an amino-terminal lipid attachment site, and two strongly hydrophobic regions close to each other in the mature protein. A mutation leading to increased permeability of the outer membrane to hydrophobic agents, previously localized to the traT gene, was shown to change a glycine residue to arginine within one of these hydrophobic regions. The same principle was found to apply to TraT of R6-5: the introduction, by site-directed mutagenesis, of either positively or negatively charged amino acids or the helix-disrupting proline in the corresponding hydrophobic region led to increased hydrophobic permeability of the outer membrane.
Determination of Iron with o-Phenanthroline: A Spectrophotometric Study (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Iron with o-Phenanthroline: A Spectrophotometric StudyW. B. Fortune and M. G. MellonCite this: Ind. Eng. Chem. Anal. Ed. 1938, 10, 2, 60–64Publication Date (Print):February 1, 1938Publication History Published online1 May 2002Published inissue 1 February 1938https://pubs.acs.org/doi/10.1021/ac50118a004https://doi.org/10.1021/ac50118a004research-articleACS PublicationsRequest reuse permissionsArticle Views4110Altmetric-Citations265LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Radioimmunoassay of Tricyclic Antidepressant and Some Phenothiazine Drugs in Forensic Toxicology (1985)

A radioimmunoassay suitable for screening blood and urine samples for tricyclic antidepressant and some phenothiazine drugs in forensic toxicology is described. The assay displays a remarkably broad spectrum of cross-reactivity that enables therapeutic or subtherapeutic levels of most tricyclic antidepressants and a number of phenothiazines in blood to be detected. The antiserum is commercially available and the radioligand, a radioiodinated conjugate of N-acetyl-L-histidine and nortriptyline, is easily prepared. Blood samples require prior extraction to reduce the background but urine may be assayed directly. 75 microliters of blood or 100 microliter of urine are required. Haemolysis or decomposition of the samples, common anticoagulants and sodium fluoride do not affect the results. Data for 57 compounds are presented.
Parallel architectures for entropy coding in a dual-standard ultra-HD video encoder (2010)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.
The use of coconut husk in high pressure laminate production. (2012)

This research investigated the possibilities of applying coconut husk in fibreboard production. The objective was to reduce the amount of phenol formaldehyde (PF)-resin in highly water resistant fibreboards such as high pressure laminates (HPL). The milling process of coconut husk was analysed, tested and verified. Recommendations were worked out for the storage, transportation and preparation of coconut husks. The main steps such as preparation of raw material including resination, forming and pressing of boards, and their effects on the performance of boards were analysed. HPL boards were manufactured in the laboratory and tested following the European Norms (EN 438). Different particle sizes of coconut husk and blending ratios to wood fibre were chosen. The 100% based coconut husk HPL boards (without PF resin) showed impressive water resistance performance after the 2 hour boiling test. A ratio of PF resinated spruce fibre of 50% and the rest coconut husk showed high mechanical and physical properties
Enhanced Responses of the Basilar Artery to Activation of Endothelin-B Receptors in Stroke-Prone Spontaneously Hypertensive Rats (1995)

We tested the hypothesis that responses of the basilar artery to selective activation of endothelin-B receptors are altered during chronic hypertension. Using a cranial window in anesthetized rats, we examined responses of the basilar artery to a selective endothelin-B receptor agonist, IRL 1620, in stroke-prone spontaneously hypertensive rats (SHRSP). Under control conditions, baseline basilar artery diameter was smaller in SHRSP (196 +/- 8 microns [mean +/- SEM]) than in normotensive Wistar-Kyoto rats (WKY) (245 +/- 9 microns, P < .05). Topical application of IRL 1620 (10(-8) mol/L) dilated the basilar artery by 27 +/- 5% in WKY and 56 +/- 4% in SHRSP (P < .05). Dilatation of the basilar artery in response to sodium nitroprusside was similar in WKY and SHRSP. In contrast, acetylcholine-induced vasodilatation in SHRSP was markedly impaired. NG-Nitro-L-arginine methyl ester and NG-nitro-L-arginine, inhibitors of nitric oxide synthase, inhibited IRL 1620-induced vasodilatation in WKY. Neither NG-nitro-L-arginine methyl ester nor indomethacin attenuated vasodilatation produced by IRL 1620 in SHRSP. The major finding is that dilator responses of the basilar artery to selective activation of endothelin-B receptors are paradoxically enhanced in SHRSP compared with WKY. Dilator responses of the basilar artery to endothelin-B receptor activation are mediated by endothelium-derived relaxing factor in WKY. In contrast, responses to activation of endothelin receptors in SHRSP do not depend on the production of nitric oxide or prostanoids.
Prediction of Safety Objective of an Enterprise Using Fuzzy Neural Network (2012)

Fuzzy neural network (FNN) method is presented where a functional model assists in a goal oriented prediction of safety objective and the FNN model based on time series is developed for prediction of the accident frequency rate which is one of important indices for safety objective management in an enterprise. The model is built in accordance with a connection link between fuzzy logic and neural computing. The fuzzy cluster identification algorithm is adopted to confirm the number of the best hidden layer nodes of the network. The FNN has capability to develop complex, nonlinear functional relationships between input–output patterns based on limited and sometimes inconsistent data, and is therefore suitable to predict the accident frequency rate on the basis of data obtained from historical data of the enterprise. Comparing with prediction results of the experiment of BP neural network model, the results of FNN model show that the prediction accuracy in function is reliable and practical.