gebhart/patrepeval huggingface dataset:
OX26/CTX-conjugated PEGylated liposome as a dual-targeting gene delivery system for brain glioma (2014)

The PEGylated liposomes modified with OX26 and CTX are able to significantly promote cell transfection, increase the transport of plasmid DNA across the BBB and afterwards target the brain glioma cells in vitro and in vivo, exhibit the most significant therapeutic efficacy. The ligand OX26 plays a critical role in transporting the lipoplexes across the BBB, and CTX acts as a major role in targeting brain glioma cells. The results would encourage further developments for non-invasive targeting therapy of brain gliomas by intravenous injection.
Fullerene−Porphyrin Constructs (2004)

Porphyrins and fullerenes are spontaneously attracted to each other. This new supramolecular recognition element can be used to construct discrete host-guest complexes, as well as ordered arrays of interleaved porphyrins and fullerenes. The fullerene-porphyrin interaction underlies successful chromatographic separations of fullerenes, and there are promising applications in the areas of porous framework solids and photovoltaic devices.
Political Advertising and the Geography of Voting in England at the 1983 General Election (1985)

At each general election in Britain, the political parties spend money on both their national campaign and the individual campaign in each constituency. For the latter, there are limits on the amount that can be spent, determined by the type of constituency and its number of voters. This paper presents and tests models suggesting how the parties should spend money on advertising across the constituencies—the geography of spending—and how that spending should influence the result—the geography of voting. Results show that where parties spent did not seem especially rational, but that spending had a significant impact on the distribution of votes.
Who treats medical conditions more cost efficiently? (1994)

Total costs in HMOs are 10% to 40% below those in indemnity plans; however, investigators have not examined the types of medical conditions that HMO providers treat more cost efficiently than indemnity providers. The present study was designed to evaluate if managed care health plan specialists treat complex conditions as cost efficiently as the HMO primary care providers treated the less-complex conditions and, if not, why?
IP Multimedia Subsystem SIP Registration Signaling Evaluation for Mission Critical Communication Systems (2015)

The performance of IMS affect mission critical applications which has a strict requirements due to its special operating nature and associated tasks. End-end Delay of the access technology components along with IMS entities affect the end-to-end signaling and Quality of Experience (QoE) offered for the end user in large scale systems. Having a generic system that has IMS core network serving both legacy mobile users and mission critical system users will introduce overload especially at the IMS side. In this paper evaluation of IMS and SIP performance metrics and KPIs was investigated. Scenarios with increasing number of clients and devices that are trying to register in short time period were also investigated.
Thermosets from highly functional methacrylated epoxidized sucrose soyate (2014)

Highly functional biobased methacrylate oligomers were synthesized via the reaction between methacrylic acid and epoxidized sucrose soyate (ESS); then, biobased thermosets were produced from free-radical curing of these methacrylates using styrene as a reactive diluent. The methacrylated ESS resins (MESSs) were characterized using gel permeation chromatography, Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance spectroscopy and viscosity measurements. MESS were mixed with styrene at different ratios and cured by free-radical polymerization using peroxides as the initiators to form thermosets. The extent of cure was confirmed by FTIR and gel content determinations. The properties of the thermosets were studied using tensile testing, dynamic mechanical thermal analysis and thermogravimetric analysis. Compared to their counterparts based on a reference, methacrylated epoxidized soybean oil, thermosets based on MESS showed much higher glass transition temperature (T g ) and better mechanical properties, which can be attributed to the unique combination of high methacrylate functionality and the rigid sucrose core in the MESS oligomers.
Silica-bonded S-sulfonic Acid as a Recyclable Catalyst for Synthesis of 2,3-Dihydroquinazolin-4（1H）-ones (2011)

2,3-Dihydroquinazolin-4 (1H ) 衍生物与结合硅石的 S 酸性硫酸基的酸在 80 点在乙醇催化的铵醋酸盐或主要的胺经由一个一个壶， isatoic 酐的三部件反应和芳香的醛被综合
A study on leadership factors in select industries (2019)

Ample research on leadership theories and styles has been done. Leaders act as catalyst to improve performance, even they create organizational culture. The traits possessed by a leader are crucial for the selection of a right leader. Present study uses both descriptive and exploratory methods. Both qualitative and quantitative tools are used. Sample size is 120, which includes, leaders at project management level, regional head, Asia Pacific, managers, owners, and heads of the departments in the IT and educational sectors across India. Pune was selected as universe for the study because, Pune is both IT and educational hub. Data obtained from interviews of select leaders are analysed by qualitative methods, whereas quantitative data obtained from survey (using 5 point Likert scale) are analysed by using a statistical tool. Secondary data were obtained from research papers and related published works. Both data set are studied and conclusions are drawn based on both. Leadership Out of fifteen important traits, only three are most significant, viz., responsibility taking ability, strong determination and participative. Leaders must have multiple traits in them but most significant among them are three. Emphasis on these three significant traits results into good band wagon of leaders in any organization.
Insignificant interference of <i>Elevit</i> in pregnant women serum samples with HBsAg immunoassay on Sysmex (2018)

Elevit intake in pregnant women shows no significant interference with HBsAg immunoassay on Sysmex.
High-speed, wide area, data intensive computing: a ten year retrospective (2002)

Modern scientific computing involves organizing, moving, visualizing, and analyzing massive amounts of data from around the world, as well as employing large-scale computation. The distributed systems that solve large-scale problems will always involve aggregating and scheduling many resources. Data must be located and staged, cache and network capacity must be available at the same time as computing capacity, etc. Every aspect of such a system is dynamic: locating and scheduling resources, adapting running application systems to availability and congestion in the middleware and infrastructure, responding to human interaction, etc. The technologies, the middleware services, and the architectures that are used to build useful high-speed, wide area distributed systems, constitute the field of data intensive computing. This paper explores some of the history and future directions of that field.
Cloning and Heterologous Expression of an Enantioselective Amidase from <i>Rhodococcus erythropolis</i> Strain MP50 (2002)

The gene for an enantioselective amidase was cloned from Rhodococcus erythropolis MP50, which utilizes various aromatic nitriles via a nitrile hydratase/amidase system as nitrogen sources. The gene encoded a protein of 525 amino acids which corresponded to a protein with a molecular mass of 55.5 kDa. The deduced complete amino acid sequence showed homology to other enantioselective amidases from different bacterial genera. The nucleotide sequence approximately 2.5 kb upstream and downstream of the amidase gene was determined, but no indications for a structural coupling of the amidase gene with the genes for a nitrile hydratase were found. The amidase gene was carried by an approximately 40-kb circular plasmid in R. erythropolis MP50. The amidase was heterologously expressed in Escherichia coli and shown to hydrolyze 2-phenylpropionamide, alpha-chlorophenylacetamide, and alpha-methoxyphenylacetamide with high enantioselectivity; mandeloamide and 2-methyl-3-phenylpropionamide were also converted, but only with reduced enantioselectivity. The recombinant E. coli strain which synthesized the amidase gene was shown to grow with organic amides as nitrogen sources. A comparison of the amidase activities observed with whole cells or cell extracts of the recombinant E. coli strain suggested that the transport of the amides into the cells becomes the rate-limiting step for amide hydrolysis in recombinant E. coli strains.
Absorption of laser light in overdense plasmas by sheath inverse bremsstrahlung (1994)

The original sheath inverse bremsstrahlung model [P. J. Catto and R. M. More, 1977] is modified by including the vxB term in the equation of motion. It is shown that the present results axe significantly different from those derived without the vxB term. The vxB term is also important in interpreting the absorption mechanism. If the vxB term were neglected, the absorption of the light would be incorrectly interpreted as an increase in the transverse electron temperature. This would violate the conservation of the transverse components of the canonical momentum, in the case of a normally incident laser light. It is also shown that both the sheath inverse bremsstrahlung and the anomalous skin effect are limiting cases of the same collisionless absorption mechanism. Finally, results from PIC plasma simulations are compared with the absorption coefficient calculated from the linear theory.
AN INTRODUCTION TO MODERN MOLECULAR GENETICS (1989)

Journal Article AN INTRODUCTION TO MODERN MOLECULAR GENETICS Get access N. D. HALL, N. D. HALL Bath Institute for Rheumatic Diseases, RNHRD and Pharmacology Group, University of Bath, and Department of Medicine, University of Bristol Correspondence to: Dr. Hall Search for other works by this author on: Oxford Academic PubMed Google Scholar P. A. DIEPPE P. A. DIEPPE Bath Institute for Rheumatic Diseases, RNHRD and Pharmacology Group, University of Bath, and Department of Medicine, University of Bristol Search for other works by this author on: Oxford Academic PubMed Google Scholar Rheumatology, Volume 28, Issue 1, February 1989, Pages 74–76, https://doi.org/10.1093/rheumatology/28.1.74 Published: 01 February 1989
<i>Ab Initio</i>Studies of the Antiviral Drug 1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl) thymine (1985)

The antiviral drug 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl) thymine (FMAU) exhibits a high therapeutic index against a number of herpesviruses. As with other drugs which are nucleoside analogs, such as 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and others, the activity seems to be strongly related to the presence of a fluorine atom in the sugar moiety, in the arabino position. Theoretical calculations, using quantum-chemical methods, are used to elucidate the role of the fluorine in the arabino position and to provide information about the sugar puckering. The results seem to indicate that the fluorine atom prevents the rotation of the base around the sugar-base bond, locking it into an anti structure (Fig. 2,A3) which might be related to its exposure to enzymatic attack. The sugar study confirms the endo position (above the plane) of the C'2 carbon as opposed to the endo position of the C'3 carbon.
Relevant CIR parameters selection for fingerprinting based location algorithm (2015)

This paper investigates the relevance of Channel Impulse Response (CIR) parameters for fingerprint based localization algorithm. We consider in this study a WLAN environment where a Multi-Layer Neural Network (MLNN) learns off-line the location from the location-dependent parameters of the CIR. Then, it calculates on-line the accurate position of a mobile station from given fingerprints. More importantly, an advanced study is conducted to identify the relevant parameters of CIR to be used as fingerprints which offer lower complexity and high location accuracy.
Early rejection and pathological changes in combined pancreaticoduodenal and kidney allotransplantation in pigs. (2002)

Urine amylase is the early marker of acute rejection in SPKT with bladder drainage of pancreatic exocrine secretion. The pathological change of kidney allograft is most significant in SPKT.
NASA-OAST photovoltaic energy conversion program (1984)

The NASA program in photovoltaic energy conversion research is discussed. Solar cells, solar arrays, gallium arsenides, space station and spacecraft power supplies, and state of the art devices are discussed.
ChemInform Abstract: Characteristics of New Crown Compounds (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis and secretion of apolipoprotein A1 by chick breast muscle. (1983)

The present work shows that chick breast muscles synthesize and secrete a protein which is very similar to chicken serum apolipoprotein A1 (Apo-A1), the major protein constituent of serum "high density" lipoprotein particles. This conclusion is based on the following observations. 1) When chick breast muscle explants were incubated in the presence of radioactive amino acids, a labeled protein of the same size as serum Apo-A1 (Mr approximately equal to 27,000) accumulated in the incubation media; 2) the muscle-derived secretory protein and serum Apo-A1 generated the same size distribution of peptide fragments following digestion with Staphylococcus aureus V8 protease; and 3) antibodies raised against serum Apo-A1 specifically precipitated the radioactive muscle secretory protein. The newly secreted muscle-derived Apo-A1 was associated with lipid, as judged by its "flotation" behavior during centrifugation of the labeled incubation media in the presence of 0.2 g/ml of sodium bromide; this observation suggests that muscle explants secreted Apo-A1 molecules as part of lipoprotein particles or that these Apo-A1 molecules became associated with lipid shortly after their secretion. The present work, together with the very recent report by Blue et al. (Blue, M.L., Ostapchuk, P., Gordon, J.S., and Williams, D.L. (1982) J. Biol. Chem. 257, 11151-11159) demonstrate that avian tissues other than liver and intestinal mucosa synthesize and secrete Apo-A1. Results of short term amino acid incorporation experiments showed that chick breast muscles synthesize Apo-A1 at high rates only during the terminal stages of embryonic development and early stages of postembryonic maturation. Around the time of hatching, the relative rate of synthesis of Apo-A1 by chick breast muscle was found to be higher than in liver, a documented major site of synthesis of this apolipoprotein. Possible physiological implications of the present work will be considered.
Overview of Advances in the Masonry Structure Strengthening using Fiber Reinforced Polymer Composite Materials (2013)

Fiber reinforced polymer composite materials have many advantages,such as the high ratio of strength to weight and the high corrosion resistance.It has been widely applied in aviation,aircraft,shipbuilding,wind power,and mechanics.From 80s of last century,civil engineering researchers have begun to follow with interest the behaviors and properties of the different types of civil engineering structures strengthened by fiber reinforced polymer composite materials,and to research the utilization of fiber reinforced polymers to strengthen and rehabilitate civil engineering structures.This paper reviewed the advances in the masonry structure strengthening and retrofitting by fiber reinforced polymers,particularly presented the findings and achievements in scientific research,for instance the shear capacity,anti-seismic,bending out of plane,bonding property,and other aspects.
Wavelets for computationally efficient hyperspectral derivative analysis (2001)

Smoothing followed by a derivative operation is often used in the analysis of hyperspectral signatures. The width of the smoothing and/or derivative operator can greatly affect the utility of the method. If one is unsure of the appropriate width or would like to conduct analysis for several widths, scale-space images can be used. This paper shows how the wavelet transform modulus-maxima method can be used to formalize and generalize the smoothing followed by derivative analysis and how the wavelet transform ran be used to greatly decrease computational costs of the analysis. The Mallat/Zhong wavelet algorithm is compared to the traditional method, convolution with Gaussian derivative filters, for computing scale-space images. Both methods are compared on two points: (1) computational expense and (2) resulting scalar decompositions. The results show that the wavelet algorithm can greatly reduce the computational expense while practically no differences exist in the subsequent scaler decompositions. The analysis is conducted on a database of hyperspectral signatures, namely, hyperspectral digital image collection experiment (HYDICE) signatures. The reduction in computational expense is by a factor of about 30, and the average Euclidean distance between resulting scale-space images is on the order of 0.02.
A Hybrid Overlay Multicast and Caching Scheme for Information-Centric Networking (2010)

It has long been realized that the use of the Internet has moved away from its original end-host centric model. The vast majority of services and applications is nowadays focused on information itself rather on the end-points providing/consuming it. However, the underlying network architecture still focuses on enabling the communication between pairs of end-hosts, leading to a series of problems, such as the inefficient utilization of network resources, demonstrated by the proliferation of peer-to-peer (P2P) and file sharing applications. In essence, the prevailing end-to-end nature of the current Internet architecture prohibits network operators from controlling the traffic carried by their networks, leaving this control entirely to end users and their applications. In this paper, we investigate the potential benefits of MultiCache, an overlay network architecture aiming at handing control back to network operators. In MultiCache proxy overlay routers enable the delivery of data either via direct multicast, or via multicast fed caches residing at the leaves of multicast delivery trees. We study crucial aspects of our architecture, paying special attention to the properties of our distributed caching scheme, and investigate the feasibility of a progressive deployment of the proposed functionality over the existing Internet.
Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles (2019)

A main challenge to broaden the biomedical application of CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9) genome editing technique is the delivery of Cas9 nuclease and single-guide RNA (sgRNA) into the specific cell and organ. An effective and very fast CRISPR/Cas9 genome editing in vitro and in vivo enabled by bioreducible lipid/Cas9 messenger RNA (mRNA) nanoparticle is reported. BAMEA-O16B, a lipid nanoparticle integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing as fast as 24 h post mRNA delivery. It is demonstrated that the simultaneous delivery of Cas9 mRNA and sgRNA using BAMEA-O16B knocks out green fluorescent protein (GFP) expression of human embryonic kidney cells with efficiency up to 90%. Moreover, the intravenous injection of BAMEA-O16B/Cas9 mRNA/sgRNA nanoparticle effectively accumulates in hepatocytes, and knocks down proprotein convertase subtilisin/kexin type 9 level in mouse serum down to 20% of nontreatment. The leading lipid nanoparticle, BAMEA-O16B, represents one of the most efficient CRISPR/Cas9 delivery nanocarriers reported so far, and it can broaden the therapeutic promise of mRNA and CRISPR/Cas9 technique further.
Quantitation of Hepatitis C Virus RNA (1996)

Letters15 July 1996Quantitation of Hepatitis C Virus RNADavid Gretch, MD, PhD, Lawrence Corey, MD, and Robert Carithers Jr., MDDavid Gretch, MD, PhDUniversity of Washington, Seattle, WA 98144Search for more papers by this author, Lawrence Corey, MDUniversity of Washington, Seattle, WA 98144Search for more papers by this author, and Robert Carithers Jr., MDUniversity of Washington, Seattle, WA 98144Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-2-199607150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Wilber and Urdea and the editorial of Tedeschi and Seeff [1] raise several useful points. Although we agree with most of the comments, we need to clarify several issues.With regard to the letter by Wilber and Urdea, we did not conclude that a prozone effect had occurred. Rather, we documented an unexpectedly high kit-to-kit variation in a subset of high-titer specimens, which showed a greater than 10-fold discordance between our reference assay (quantitative PCR) and the Chiron assay (bDNA). Because the linear range of quantitative PCR exceeds that of bDNA by several orders of magnitude, we ...REFERENCE1. Tedeschi V, Seeff LB. Diagnostic tests for hepatitis C: where are we now [Editorial]? Ann Intern Med. 1995; 123:383-5. Google Scholar Author, Article, and Disclosure InformationAuthors: David Gretch, MD, PhD; Lawrence Corey, MD; Robert Carithers Jr., MDAffiliations: University of Washington, Seattle, WA 98144 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1996Volume 125, Issue 2Page: 155-156KeywordsBiopsyChronic hepatitis CHepatitis C virusInfectious hepatitisInterferonsLiverLiver transplantationMorbidityQuality improvementRNA ePublished: 15 August 2000 Issue Published: 15 July 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Does methylmercury have a role in causing developmental disabilities in children? (2000)

Methylmercury (MeHg) is a potent neurotoxin that in high exposures can cause mental retardation, cerebral palsy, and seizures. The developing brain appears particularly sensitive to MeHg. Exposure levels in pregnant experimental animals that do not result in detectable signs or symptoms in the mother can adversely affect the offspring's development. Studies of human poisonings suggest this may also occur in humans. Human exposure to MeHg is primarily dietary through the consumption of fish: MeHg is present in all fresh and saltwater fish. Populations that depend on fish as a major source of dietary protein may achieve MeHg exposure levels hypothesized to adversely affect brain development. Increasing mercury levels in the environment have heightened concerns about dietary exposure and a possible role for MeHg in developmental disabilities. Follow-up studies of an outbreak of MeHg poisoning in Iraq revealed a dose-response relationship for prenatal MeHg exposure. That relationship suggested that prenatal exposure as low as 10 ppm (measured in maternal hair growing during pregnancy) could adversely affect fetal brain development. However, using the same end points as were used in the Iraq study, no associations have been reported in fish-eating populations. Using a more extensive range of developmental end points, some studies of populations consuming seafood have reported associations with prenatal MeHg exposure, whereas others have found none. This paper reviews the data presently available associating MeHg exposure with development and poses some of the unanswered questions in this field.