gebhart/patrepeval huggingface dataset:
Codétection par endomicroscopie multiphotonique du collagène fibrillaire rénal et des flavines tubulaires sur la souris anesthésiée dans le modèle UUO (2015)

La microscopie multiphotonique peut être utilisée pour repérer dans la profondeur du tissu le collagène et les flavines cellulaires sur des coupes de rein non marquées et non colorées dans des modèles murins de fibrose rénale. Notre but est de valider l’utilisation d’un prototype d’endomicroscope multiphotonique in vivo dans le modèle murin UUO. Les reins ont été observés sous un microscope ou via un endomicroscope multiphotonique développés, tous deux, dans un laboratoire universitaire français. Dans les 2 prototypes : – la lumière d’excitation et d’émission passent par une fibre optique ; – l’autofluorescence (2PEF) des flavines et la seconde harmonique (SHG) du collagène fibrillaire peuvent être codétectées. L’endomicroscope se distingue du microscope par sa sonde imageuse miniaturisée de 1 cm de long sur 2,2 mm de diamètre qui contient un système de micro-optique et un scanner permettant de réaliser 8 images par seconde. Les 2 prototypes permettent de co-visualiser la fibrose interstitielle et les cellules tubulaires sur des coupes de rein UUO. La capsule rénale qui est très riche en collagène fibrillaire est aussi bien visible et elle apparaît fortement épaissie dans les reins UUO. Lorsque l’endomicroscope est appliqué in vivo sur les reins de souris anesthésiées, la capsule rénale est facilement repérable. Avec une profondeur de champs de 250 μm, les tubules sont visibles jusqu’à 300 μm de profondeur sous la capsule. À cette profondeur, nous n’avons pas observé de fibrose interstitielle dans les reins UUO. Par contre, vue du dessus (et non pas en coupe) la capsule des reins UUO a un aspect moins organisé que celle des reins témoins. Nos résultats suggèrent que les modifications d’épaisseur et d’aspect de la capsule pourraient survenir au cours de la fibrose rénale et servir ainsi de marqueurs de cet état pathologique lorsqu’elles sont recherchées par endomicroscopie. Nous validons l’utilisation du prototype d’endomicroscope multiphotonique in vivo pour repérer dans des tissus non marqués, non colorés des signaux lumineux de faible intensité (2PEF et SHG) et éventuellement détecter la fibrose rénale.
A case of thyrotoxicosis after sunitinib treatment (2010)

Sunitinib is a tyrosine-kinase inhibitor used to treat metastatic renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumors. Hypothyroidism is a common side effect of sunitinib therapy. Nevertheless, overt thyrotoxicosis induced by destructive thyroiditis after sunitinib treatment is very rare. Here, we report a patient with overt thyrotoxicosis related to sunitinib therapy. (Korean J Med 78:503-506, 2010)
Uteroglobin (UG) Suppresses Extracellular Matrix Invasion by Normal and Cancer Cells That Express the High Affinity UG-binding Proteins (1998)

Uteroglobin (UG) is a steroid-inducible, multifunctional, secreted protein with antiinflammatory and antichemotactic properties. Recently, we have reported a high affinity UG-binding protein (putative receptor), on several cell types, with an apparent molecular mass of 190 kDa (Kundu, G. C., Mantile, G., Miele, L., Cordella-Miele, E., and Mukherjee, A. B. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2915-2919). Since UG is a homodimer in which the 70 amino acid subunits are connected by two disulfide bonds, we sought to determine whether UG monomers also interact with the 190-kDa UG-binding protein and if so, whether it has the same biological activity as the dimer. Surprisingly, we discovered that in addition to the 190-kDa species, another protein, with an apparent molecular mass of 49 kDa, binds reduced UG with high affinity and specificity. Both 49- and 190-kDa proteins are readily detectable on nontransformed NIH 3T3 and some murine cancer cells (e. g. mastocytoma, sarcoma, and lymphoma), while lacking on others (e.g. fibrosarcoma). Most interestingly, pretreatment of the cells, which express the binding proteins, with reduced UG dramatically suppresses extracellular matrix (ECM) invasion, when such treatment had no effect on fibrosarcoma cells that lack the UG-binding proteins. Tissue-specific expression studies confirmed that while both 190- and 49-kDa UG-binding proteins are present in bovine heart, spleen, and the liver, only the 190-kDa protein is detectable in the trachea and in the lung. Neither the 190-kDa nor the 49-kDa protein was detectable in the aorta. Purification of these binding proteins from bovine spleen by UG-affinity chromatography and analysis by SDS-polyacrylamide gel electrophoresis followed by silver staining identified two protein bands with apparent molecular masses of 40 and 180 kDa, respectively. Treatment of the NIH 3T3 cells with specific cytokines (i.e. interleukin-6) and other agonists (i.e. lipopolysaccharide) caused a substantially increased level of 125I-UG binding but the same cells, when treated with platelet-derived growth factor, tumor necrosis factor-alpha, interferon-gamma, and phorbol 12-myristate 13-acetate, did not alter the UG binding. Taken together, these findings raise the possibility that UG, through its binding proteins, plays critical roles in the regulation of cellular motility and ECM invasion.
ChemInform Abstract: SYNTHESIS OF PERFLUOROPOLY(ETHYLENE GLYCOL) ETHERS CF3(OCF2CF2)NORF (RF = CF3 OR C2F5, N = 1‐5) (1977)

Abstract Polyäthylenoxid ergibt mit Fluor die Verbindungen (I) und (II).
<title>Fuzzy logic genetic algorithm for hypercompression</title> (1997)

In this presentation, a fuzzy logic adaptive genetic algorithm (FLAGA) software engine is applied to hypercompression pre- processing. The FLAGA has a genetic algorithm (GA)-engine, tunable by fuzzy-logic rules. As a result, basic GA-engine operations, such as spanning, crossover, and mutation, have tunable rates, according to progress in the convergence process. Since the rates of these operations are not fixed but optimized in real-time, FLAGA convergence speed is at least one-order-of-magnitude higher than equivalent speed for a standard GA. In this paper, we present theoretical analysis and simulation results for this specific fuzzy logic application, as well as further considerations related to the application of FLAGA to video imaging and edge-extraction ATR (automatic target recognition).
Quantifizierung extrakranieller Karotisstenosen Magnetresonanzangiographie und Doppler-Sonographie versus intraarterielle Angiographie (1993)

Several non-invasive methods do compare with IAA in identifying and quantifying high-grade ICA stenosis and may suffice for decisions on treatment.
Linear system identification of a cold flow circulating fluidized bed (2008)

Knowledge of the solids circulation rate (SCR) is essential to the control and improved performance of a circulating fluidized bed system. In the present work, the noise model is derived using the prediction error method considering process and measurement noises acting on the cold flow circulating fluidized bed (CFCFB) with a cork particulate material. The outputs of the initial model are the total pressure drop across the riser, the pressure drop across the crossover, the pressure drop across the primary cyclone, the total pressure drop across the stand-pipe, the pressure drop across the loop seal, and the SCR. The stochastic estimate of SCR is determined from the noise model using the stochastic pressure drop estimates. The deterministic estimate is obtained through the inputs taken as move air flow, riser aeration, and loop seal fluidization air that are all independent variables of the given setup and under the control of the user. The theory has been developed to convert a complete blackbox model to a grey box model through the output-to-state transformation such that both the models of the CFCFB consists of all these output variables as the states of the system, and only pressure drops across the system as the output measurements. Thus, the final models do not include any fictitious terms and they are defined only in terms of physical parameters of the given system. Both components of SCR are separately analysed. The combined SCR response of both the noise model and deterministic model is compared with the validation data set of this state variable in terms of modelfit, and the results are shown.
Program Description and Purpose (1975)

I'd like to spend a few minutes to give a brief overview of the ARPA/AFML research program in NDE. The objectives of the program are as follows: To pursue advanced research in quantitati ve techniques for NDE To establish a focal point for NDE research To establish communication between the research community and the NOE user To promote the image of NDE
Second harmonic generation from Si/SiO/sub 2/: spectral and symmetry characteristics (2003)

Summary form only given. Second harmonic generation (SHG) only occurs, in the dipole approximation, in material that is noninversion symmetric. Consequently, in material with bulk inversion symmetry, SHG only occurs near a surface or an interface that breaks the inversion symmetry. Substantial interest has been paid to SHG from the Si(100)-SiO/sub 2/ interface because of its importance to the semiconductor industry. Results showing that SHG is sensitive to roughness at this interface have only furthered interest. Roughness is becoming critical as MOSFET gate oxide thickness shrinks to nanometer scale with shrinking gate dimension.
Ethnicity and return to work in breast cancer survivors: An exploratory qualitative study (2008)

20532 Background: Employment status after breast cancer is related to treatment recovery and quality of life (QoL). While correlates of return to work (RTW) have been previously identified in primarily Caucasian populations (eg. health status and perception of employer discrimination vs. accommodation), limited data exist regarding RTW and its relationship with QoL in ethnic minority breast cancer survivors (BCSs). Methods: Our aims were to improve our understanding of RTW in ethnically diverse BCSs and to pilot test a modified version of a previously used RTW Questionnaire. We conducted a qualitative study of RTW in BCSs from 6 ethnic groups: African-Americans, African-Caribbeans, Caucasians, Chinese, Filipinas, and Latinas. We used a sampling strategy designed to enrich for ethnic minorities and patients experiencing work problems after diagnosis. We organized ethnically cohesive focus groups of 4–6 BCSs who had completed treatment for stage I-III disease and were employed 3 mos. prior to diagnosis. Focus group discussions were audio- and video-recorded, transcribed, and analyzed for content and themes. Participants also completed the RTW questionnaire and gave written feedback. Results: We interviewed 24 subjects in 6 groups. Participants mentioned fear of gossip and/or pity, lack of schedule flexibility for doctors’ visits, cancer-related discrimination, stress, and unpleasant associations with medical equipment at work. Self-image was important among the Caucasian BCSs, while privacy at work was a common theme among all but the Chinese and Latina BCSs. For some, the entire year after diagnosis was a time of perceived treatment, even if all medical therapy had been completed. Those with a strong family history of breast cancer worked through their treatment and said work helped them cope. Positive aspects of early RTW included feelings of independence and wellness and finding a support system among coworkers. The average time for questionnaire completion and feedback was 25.8 min. Conclusions: Ethnically diverse BCSs experience an array of barriers to RTW, some of which may be influenced by ethnicity and culture. A quantitative study using an ethnically sensitive and translated RTW questionnaire is needed to better understand RTW in BCSs of different ethnicities. No significant financial relationships to disclose.
Indigenous fermented foods and beverages produced in Latin America (2013)

Indigenous fermented foods form an intricate part of the diet throughout the world and have been produced for centuries as a method of food conservation. These foods, produced using locally grown raw materials and following traditional methods, are often associated to beneficial effects on their consumers. However, since indigenous fermented foods are often produced by individuals with little or no knowledge of the microbial processes involved, food safety and hygienic conditions are often overlooked. The aim of this review is to improve the knowledge base of the biotechnological processes involved in the production of indigenous fermented foods of Latin America. These include beverages prepared from the fermentation of maize (Chicha de jora and Pozol), cassava (Caixiri and Cauim), sugar cane (Cachaça), carob beans (Aloja) and agave (Pulque and Mezclal) and fermented foods such as the potato-based Tocosh. The diversity of the raw materials used as substrates and methodologies used will also be helpful in understanding the cultural habits of various and often geographically isolated cultures. Although mass-production of these indigenous fermented foods is limited by the availability of raw materials and their short shelf-life greatly limits their introduction into foreign markets, increased knowledge of the processes and microorganisms involved will be useful in improving and standardizing their production and increasing consumer acceptance and safety.
Intermittent Dissipation of a Passive Scalar in Turbulence (1998)

The probability density function (PDF) of passive scalar dissipation $P(\ensuremath{\epsilon})$ is found analytically in the limit of large Peclet and Prandtl numbers (Batchelor-Kraichnan regime) in two dimensions. The tail of PDF at $\ensuremath{\epsilon}\ensuremath{\gg}〈\ensuremath{\epsilon}〉$ is shown to be stretched exponent $\mathrm{ln}P(\ensuremath{\epsilon})\ensuremath{\propto}{\ensuremath{\epsilon}}^{1/3}$; at $\ensuremath{\epsilon}\ensuremath{\ll}〈\ensuremath{\epsilon}〉$, $P\ensuremath{\propto}1/\sqrt{\ensuremath{\epsilon}}$.
Phytoplankton and Cloudiness in the Southern Ocean (2006)

The effect of ocean biological productivity on marine clouds is explored over a large phytoplankton bloom in the Southern Ocean with the use of remotely sensed data. Cloud droplet number concentration over the bloom was twice what it was away from the bloom, and cloud effective radius was reduced by 30%. The resulting change in the short-wave radiative flux at the top of the atmosphere was -15 watts per square meter, comparable to the aerosol indirect effect over highly polluted regions. This observed impact of phytoplankton on clouds is attributed to changes in the size distribution and chemical composition of cloud condensation nuclei. We propose that secondary organic aerosol, formed from the oxidation of phytoplankton-produced isoprene, can affect chemical composition of marine cloud condensation nuclei and influence cloud droplet number. Model simulations support this hypothesis, indicating that 100% of the observed changes in cloud properties can be attributed to the isoprene secondary organic aerosol.
Is Nanostructuring Sufficient To Get Catalytically Active Au? (2016)

Gold nanoparticles on transition-metal oxides were synthesized by two different methods: precipitation and photoinduced decomposition of an intermediate gold–azido complex. Only samples prepared by the precipitation method showed significant CO conversion at low temperature. XPS shows the formation of two Au species (Au0 and Auδ+) on the surface of active Au/TiO2 and Au/Fe2O3 samples. The energy shift of the Auδ+ peak depends on the support and is 0.6 and 0.9 eV for Au/TiO2 and Au/Fe2O3, respectively. TEM images indicate the formation of overlayer on Au particles. These results prove Au activation via a strong metal–support interaction, on the basis of the strong influence of the support on the electronic structure of the gold through charge transfer and stabilization of low-coordinated Au atoms.
Glucose uptake in Azotobacter vinelandii occurs through a GluP transporter that is under the control of the CbrA/CbrB and Hfq-Crc systems (2017)

Azotobacter vinelandii, a strict aerobic, nitrogen fixing bacterium in the Pseudomonadaceae family, exhibits a preferential use of acetate over glucose as a carbon source. In this study, we show that GluP (Avin04150), annotated as an H<sup>+</sup>-coupled glucose-galactose symporter, is the glucose transporter in A. vinelandii. This protein, which is widely distributed in bacteria and archaea, is uncommon in Pseudomonas species. We found that expression of gluP was under catabolite repression control thorugh the CbrA/CbrB and Crc/Hfq regulatory systems, which were functionally conserved between A. vinelandii and Pseudomonas species. While the histidine kinase CbrA was essential for glucose utilization, over-expression of the Crc protein arrested cell growth when glucose was the sole carbon source. Crc and Hfq proteins from either A. vinelandii or P. putida could form a stable complex with an RNA A-rich Hfq-binding motif present in the leader region of gluP mRNA. Moreover, in P. putida, the gluP A-rich Hfq-binding motif was functional and promoted translational inhibition of a lacZ reporter gene. The fact that gluP is not widely distributed in the Pseudomonas genus but is under control of the CbrA/CbrB and Crc/Hfq systems demonstrates the relevance of these systems in regulating metabolism in the Pseudomonadaceae family.
Cardiovascular Autonomic Dysfunction Is the Most Common Cause of Syncope in Paced Patients (2019)

<b>Introduction:</b> Syncope and orthostatic intolerance in paced patients constitute a common clinical dilemma. We, thus, aimed to determine the etiology of syncope and/or symptoms of orthostatic intolerance in paced patients. <b>Methods:</b> Among 1,705 patients with unexplained syncope and/or orthostatic intolerance that were investigated by cardiovascular autonomic tests, including Valsalva <i>maneuver</i>, active standing, carotid sinus massage, and tilt-testing, 39 patients (2.3%; age 65.6 years; 39% women) had a cardiac implantable electronic device (CIED). We explored past medical history, diagnoses found during cardiovascular autonomic tests, and the further clinical workup, in case of negative initial evaluation. <b>Results:</b> An etiology was identified during cardiovascular autonomic tests in 36 of the 39 patients. Orthostatic hypotension (<i>n</i> = 16; 41%) and vasovagal syncope (<i>n</i> = 12; 31%) were the most common diagnoses. There were no cases of pacemaker dysfunction. The original pacing indications followed guidelines (sick-sinus-syndrome in 16, atrioventricular block in 16, atrial fibrillation with bradycardia in five). Twenty-two of the 39 patients (56%) had experienced syncope prior to the original <i>CIED</i> implantation. Orthostatic hypotension was diagnosed in seven (32%) and vasovagal syncope in nine (41%) of these patients. Of the 17 patients that had not experienced syncope prior to the original CIED implantation, nine patients (53%) were diagnosed with orthostatic hypotension and vasovagal syncope was diagnosed in three (18%). Of the 39 patients, two had implantable cardioverter-defibrillators to treat malignant ventricular arrhythmias diagnosed after syncopal episodes. <b>Conclusion:</b> Cardiovascular autonomic tests reveal the etiology of syncope and/or orthostatic intolerance in the majority of paced patients. The most common diagnosis was orthostatic hypotension (40%) followed by vasovagal syncope (30%), whereas there were no cases of pacemaker dysfunction. Our results emphasize the importance of a complete diagnostic work-up, including cardiovascular autonomic tests, in paced patients that present with syncope and/or orthostatic intolerance.
Purification and reconstitution in lipid bilayer membranes of an outer membrane, pore-forming protein of Aeromonas salmonicida (1983)

We have purified a major outer membrane protein from Aeromonas salmonicida. This 42-kilodalton protein shared several physical characteristics with enterobacterial porins in that it was noncovalently associated with the peptidoglycan, it was released from the peptidoglycan in the presence of 0.1 M NaCl and sodium dodecyl sulfate, and its mobility on sodium dodecyl sulfate-polyacrylamide gels was dependent on the solubilization temperature before electrophoresis. When added to the aqueous solution bathing a planar bilayer membrane it caused the conductance of the membrane to increase by several orders of magnitude. At lower protein concentrations, single channels with an average conductance of 1.6 nS in 1 M KCl were incorporated into the membrane in a stepwise fashion. Evidence that the protein formed a large, relatively nonselective, water-filled channel was obtained by performing single-channel experiments at different NaCl concentrations and in a variety of different salts. Current through the channel was a linear function of the applied voltage, and no evidence of voltage gating was observed. In addition, we obtained evidence for a 43-kilodalton channel-forming protein in the outer membrane of A. hydrophila with a similar single-channel conductance as the 42-kilodalton protein in 1 M NaCl.
Proteinase Inhibitor 6 Cannot Be Secreted, Which Suggests It Is a New Type of Cellular Serpin (1996)

We have recently described a new serine proteinase inhibitor, proteinase inhibitor 6 (PI-6). This serpin has features that suggest it may function intracellularly, but its close resemblance to ovalbumin serpins like plasminogen activator inhibitor 2 (PAI-2) raises the possibility that it is secreted to regulate an extracellular proteinase. To determine whether PI-6 is secreted, we have examined its cellular distribution by immunohistochemistry and have attempted to induce its release from platelets and from cultured cells. We find that PI-6 is present in endothelial and epithelial cells, but it is apparently cytoplasmic and it is not released from cells in response to phorbol ester, dibutyryl cAMP or tumor necrosis factor alpha treatment. It is also not released from activated platelets. The addition of a conventional signal peptide to the amino terminus of PI-6 directed its translocation into the endoplasmic reticulum (ER), resulting in glycosylation but not secretion of the molecule. By contrast, the addition of the same signal peptide to PAI-2 markedly enhanced its translocation and secretion. Glycosylated PI-6 was sequestered in the ER and was incapable of interacting with thrombin. The failure of PI-6 to move along the secretory pathway, and the loss of inhibitory function of ER-localized PI-6, demonstrates that unlike PAI-2, PI-6 is not naturally secreted. Taken together, these results suggest that PI-6 has evolved to fulfil an intracellular role and that it represents a new type of cellular serpin.
Chronic ethanol administration increases the binding of sup 3 H Ro-15-4513 in primary cultured spinal cord neurons (1989)

Ro 15-4513 (ethyl-8-azido-5, 6-dihydro-5-methyl-6-oxo-4H-imidazo (1,5{alpha}), (1,4) benzodiazepine-3-carboxylate) is reported to be a selective ethanol antagonist in biochemical and behavioral studies. The effect of chronic ethanol treatment on the binding of ({sup 3}H)Ro 15-4513 was investigated in cultured spinal cord neurons, which are shown to possess all the elements of GABA benzodiazepine receptor complex. Chronic ethanol treatment (50 mM for 6 hr, 12 hr, 18 hr, 3 days, and 5{sub 3} days) produced an increase in the specific binding of ({sub 3}H)Ro 15-4513. The increase in binding in these neurons was due to an increase in the number (B{sub max}) of receptor sites. This effect was specific for Ro 15-4513, since identical ethanol treatment did not alter the binding of benzodiazepine antagonist ({sup 3}H)Ro 15-1788 or agonist ({sup 3}H)flunitrazepam or inverse agonist ({sup 3}H)methyl-{beta}-carboline-3-carboxylate. Similar results have been reported following chronic ethanol treatment to rats. These results suggest that the Ro 15-4513 binding sites on the oligomeric GABA receptor complex are altered following chronic ethanol administration, and support the notion of a unique role of Ro 15-4513 as an ethanol antagonist.