gebhart/patrepeval huggingface dataset:
Photocatalytic and photoelectrochemical reactions of aqueous solutions of formic acid, formaldehyde, and methanol on platinized cadmium sulfide powder and at a cadmium sulfide electrode (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocatalytic and photoelectrochemical reactions of aqueous solutions of formic acid, formaldehyde, and methanol on platinized cadmium sulfide powder and at a cadmium sulfide electrodeMichio Matsumura, Masahiro Hiramoto, Toshio Iehara, and Hiroshi TsubomuraCite this: J. Phys. Chem. 1984, 88, 2, 248–250Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/j150646a017https://doi.org/10.1021/j150646a017research-articleACS PublicationsRequest reuse permissionsArticle Views467Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Experimental infection with Trypanosoma brucei, Trypanosoma rhodesiense, and Trypanosoma gambiense in beagle-dogs (1970)

Journal Article Experimental infection with Trypanosoma brucei, Trypanosoma rhodesiense, and Trypanosoma gambiense in beagle-dogs Get access F. Evens, F. Evens Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Marsboom, R. Marsboom Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Mortelmans J. Mortelmans Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 64, Issue 1, 1970, Pages 161–162, https://doi.org/10.1016/0035-9203(70)90212-9 Published: 01 January 1970
The Hamiltonian approach to neural networks dynamics (1991)

The Hamiltonian concept of partial differential equation (PDE) theory is used to describe the dynamics of arbitrary neural nets. Pattern as well as learning dynamics are admitted simultaneously. Any method to determine the minima of the Hamiltonian with respect to the weight functions is shown to create an associated learning rule. Since arbitrary topologies and learning functions can be inscribed into the Hamiltonian, the concept turns out to be useful for a unified treatment of the dynamics of neural nets. Former results on the dynamics of special networks and learning functions are recovered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<title>Estimating snow cover and grain size from AVIRIS data with spectral mixture analysis and modeled snow spectra</title> (1997)

Models of hydrology and climate in alpine and other seasonally snow-covered regions require input of snow- covered area (SCA) and snow surface grain size. The spectral signature of snow depends on the snow grain size. We have shown in earlier work that to map either SCA or grain size with optical data, one must know the distribution of the other variable. Hence, we solve for SCA or grain size simultaneously with spectral mixture analysis. Alpine regions frequently exhibit large snow grain size gradients due to rugged terrain. Because the spectral signature of snow is dependent on grain size, the grain size gradients translate into spectral gradients. Snow must then be represented by a range of endmembers. To provide the range and resolution of grain size, we use modeled snow spectra of varying brain size as snow endmembers. To complete the spectral mixture library, we incorporate reference endmembers of vegetation, rock, and soil. On airborne visible/IR imaging spectrometer data of the Sierra Nevada, CA, we ran multiple mixture models. We established constraints on mixture RMS, residual, and fractions to select a subset of physically realistic models. The optimal mixture was then selected from this subset by means of the least RMS. The snow endmember fraction and grain size of the optimal mixture provide the estimates of sub-pixel SCA and surface grain size, respectively.
Comparative Glycoproteome Analysis: Dynamics of Protein Glycosylation during Metamorphic Transition from Pelagic to Benthic Life Stages in Three Invertebrates (2011)

The life cycle of most benthic marine invertebrates has two distinct stages: the pelagic larval stage and the sessile juvenile stage. The transition between the larval stage and the juvenile stage is often abrupt and may be triggered by post-translational modification of proteins. Glycosylation, a very important post-translational modification, influences the biological activity of proteins. We used two-dimensional gel electrophoresis (2-DE) followed by glycoprotein-specific fluorescence staining and mass spectrometry with the goal of identifying glycosylation pattern changes during larval settlement and metamorphosis in barnacles, bryozoans, and polychaetes. Our results revealed substantial changes in the protein glycosylation patterns from larval to juvenile stages. Before metamorphosis, the degree of protein glycosylation was high in the barnacle Balanus (=Amphibalanus) amphitrite and the spionid polychaete Pseudopolydora vexillosa, whereas it increased after metamorphosis in the bryozoan Bugula neritina. We identified 19 abundant and differentially glycosylated proteins in these three species. Among the proteins, cellular stress- and metabolism-related proteins exhibited distinct glycosylation in B. amphitrite and B. neritina, whereas fatty acid metabolism-related proteins were abundantly glycosylated in P. vexillosa. Furthermore, the protein and gene expression analysis of some selected glycoproteins revealed that the degree of protein glycosylation did not always complement with transcriptional and translational changes associated with the larval-juvenile transition. The current study provides preliminary information on protein glycosylation in marine invertebrates that will serve as a solid basis for future comprehensive analysis of glycobiology during larval settlement and metamorphosis.
Effect of Stress on Creep at High Temperatures (1957)

Abstract Experimental investigations on pure aluminum and its dilute solid-solution alloys revealed that the high-temperature creep rate ϵ̇ is related to the stress σ by ϵ̇ ∼ σn for low stresses and ϵ̇ ∼ eBσ for high stresses where n and B are constants independent of the creep strain and temperature. According to a preliminary dislocation-climb model for high-temperature creep, the activation energy for creep is that for self-diffusion, the effect of stress on the creep rate depends on the number of active Frank-Read sources, and the rate of climb depends on the structure as determined by the pattern of climbing dislocations. Many of the experimental observations on high-temperature creep can be accounted for by this model.
Leukocyte glutamate dehydrogenase in patients with degenerative neurological disorders. (1989)

Leukocyte glutamate dehydrogenase in This could account for the variability repor- patients with degenerative neurological ted and the failure to heat inactivate a disorders substantial number of control leukocytes.The authors have limited their heat inactiva-Sir: Aubby et al' recently published the tion studies to those patients with total GDH results of an extensive study which evaluated activity of less than 50% of normal, which the levels of glutamate dehydrogenase may represent a particular subgroup among (GDH) in patients with cerebellar and/or those with GDH abnormalities.6Previous
CN-12 * PINEAL PARENCHYMAL TUMOUR OF INTERMEDIATE DIFFERENTIATION: CASE SERIES FROM A SINGLE INSTITUTE (2014)

INTRODUCTION: Pineal parenchymal tumours of intermediate differentiation (PPTID) are a group of rare tumours with intermediate malignant potential between pineocytoma and pineoblastoma, for which there is currently no standard treatment paradigm. METHODS: Between 2001 and 2014, five patients with PPTID were treated at our institute. We retrospectively evaluated clinical outcomes. Patient demographics, presentation, staging, surgery, radiotherapy (RT) technique, late toxicities and any chemotherapy administered were noted from the hospital electronic data base. RESULTS: Patient age range 20-74 years. Common presenting symptom was headache and visual disturbance and neurological sign was diplopia. All had ventriculostomy plus or minus ventriculo-peritoneal shunt to relieve hydrocephalus. Two patients had biopsy only and three patients had excision of pineal tumour. Three patients underwent whole brain RT with boost to pineal region [35.07Gy in 21 fractions - whole brain, average boost dose- 17.81Gy (16.7- 20.04 Gy) at 1.67Gy/fraction]. Two patients had limited field RT to the pineal region (54Gy and 39.6 Gy delivered in 1.8 Gy/fraction). Four patients had complete radiological response on MRI post-RT. One patient had partial radiological response. Two patients recurred after an average disease free survival period of 54.5 months from diagnosis: one recurred locally and was retreated with radiosurgery; the other developed disseminated leptomeningeal disease and received platinum based palliative chemotherapy. Four patients are alive to date. Average overall survival including relapsed patients is 102.5 months. Median DFS and OS are 41 and 100 months respectively. All patients developed mild cognitive impairment. The patient who received platinum chemotherapy developed severe neuropathy. CONCLUSION: Patients with PPTID in this case series survived medium term and four remain on follow up. A prospective multi institutional study is recommended due to the potential for late adverse effects. However, because this entity is rare, the difficulties in achieving this are recognised therefore cases should be collated at centres for review.
A novel mechanism for upregulation of the <i>Escherichia coli</i> K‐12 <i>hmp</i> (flavohaemoglobin) gene by the ‘NO releaser’, <i>S</i>‐nitrosoglutathione: nitrosation of homocysteine and modulation of MetR binding to the <i>glyA‐hmp</i> intergenic region (1998)

The flavohaemoglobin gene, hmp, of Escherichia coli is upregulated by nitric oxide (NO) in a SoxRS-independent manner. We now show that hmp expression is also upregulated by S-nitrosoglutathione (GSNO, widely used as an NO releaser) and sodium nitroprusside (SNP, which is a NO+ donor). Elevated homocysteine (Hcy) levels, achieved either by adding Hcy extracellularly or using metE mutants, decreased hmp expression. Conversely, metC mutants (defective in Hcy synthesis) had higher levels of hmp expression. Mutations in metR abolished hmp induction by GSNO and SNP, and hmp expression became insensitive to Hcy. We propose that the previously documented modulation by Hcy of MetR binding to the glyA-hmp intergenic regulatory region regulates hmp transcription. Although two MetR binding sites are present in this region, only the higher affinity site proximal to hmp is required for hmp induction by GSNO and SNP. GSNO and SNP react with Hcy in vitro under physiologically relevant conditions of pH and temperature generating S-nitrosohomocysteine, although in the latter case this would be co-ordinated to the Fe in SNP as a stable species. The free S-nitrosocysteine generated in the reaction with GSNO breaks down to release NO more readily than via homolysis of GSNO. As GSNO and SNP upregulate hmp similarly, the NO released in the former case on reaction with homocysteine cannot be involved in hmp regulation.
KLRE/I1 and KLRE/I2: A Novel Pair of Heterodimeric Receptors That Inversely Regulate NK Cell Cytotoxicity (2008)

NK cells identify infected, neoplastic, or MHC-disparate target cells via several different receptors. The NK cell receptor KLRE1 lacks known signaling motifs but has nevertheless been shown to regulate NK cell-mediated cytotoxicity. Here we demonstrate that KLRE1 forms functional heterodimers with either KLRI1 or KLRI2. Cotransfection with KLRE1 was necessary for surface expression of the NK cell receptor chains KLRI1 and KLRI2 in 293T cells. Moreover, KLRE1 can be coimmunoprecipitated with KLRI1 or KLRI2 from transfected NK cell lines. By flow cytometry, KLRE1 and KLRI1 showed colinear expression on NK cells, suggesting surface expression as heterodimers. Unlike other killer cell lectin-like receptors, KLRE1/KLRI1 and KLRE1/KLRI2 heterodimers predominantly migrated as single chains in SDS-PAGE, indicating noncovalent association. KLRI1 was coimmunoprecipitated with the tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1. In accordance with an inhibitory function, anti-HA Ab induced reduced killing of FcR-bearing targets by KLRI1-HA-transfected NK cell lines in a redirected cytotoxicity assay. Reciprocally, KLRI2-HA transfectants displayed increased killing in this assay. Finally, Ab to KLRE1 induced inhibition in KLRI1-transfected cells but increased cytotoxicity in KLRI2 transfectants, demonstrating that KLRE/I1 is a functional inhibitory heterodimer in NK cells, whereas KLRE/I2 is an activating heterodimeric receptor.
Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa (2022)

The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (B.1.351) and Delta (B.1.617.2) variants, respectively<sup>1-3</sup>. In November 2021, genomic surveillance teams in South Africa and Botswana detected a new SARS-CoV-2 variant associated with a rapid resurgence of infections in Gauteng province, South Africa. Within three days of the first genome being uploaded, it was designated a variant of concern (Omicron, B.1.1.529) by the World Health Organization and, within three weeks, had been identified in 87 countries. The Omicron variant is exceptional for carrying over 30 mutations in the spike glycoprotein, which are predicted to influence antibody neutralization and spike function<sup>4</sup>. Here we describe the genomic profile and early transmission dynamics of Omicron, highlighting the rapid spread in regions with high levels of population immunity.
Iron porphyrin-modified electrodes: influence of the method of modification on the stability and electroactivity in oxidation of sulfite or hydrogensulfite in ethanol–water solutions (2009)

The aim of this work is to study four types of modification of a glassy carbon electrode by Fe(III)-tetrakis(p-tetraaminophenyl)porphyrin and determine the influence of the method of immobilization of the complex on glassy carbon in electrocatalytic properties for the sulfite and hydrogensulfite oxidation in ethanol–water. The first modification was deposition of a drop of solution containing the porphyrin on a glassy carbon electrode and evaporation of the solvent (dry-drop method). The second method was immersion of the electrode at 54°C in a solution of dimethylformamide containing the porphyrin for 2 h. The third method consisted of the same heating treatment but after formation of a chemical bond of 4-aminopyridine on the glassy carbon surface, which acts as an axial ligand for the first layer of porphyrin. The fourth method involves electropolymerization of the porphyrin on the electrode surface. Important differences in stability, the potential where the oxidation wave begins and selectivity of the electrode to sulfite or hydrogensulfite were observed. The behavior of the polymer-modified electrode is different in water compared to ethanol–water.
The NANOGrav 15-year Data Set: Search for Anisotropy in the Gravitational-Wave Background (2023)

The North American Nanohertz Observatory for Gravitational Waves (NANOGrav) has reported evidence for the presence of an isotropic nanohertz gravitational wave background (GWB) in its 15 yr dataset. However, if the GWB is produced by a population of inspiraling supermassive black hole binary (SMBHB) systems, then the background is predicted to be anisotropic, depending on the distribution of these systems in the local Universe and the statistical properties of the SMBHB population. In this work, we search for anisotropy in the GWB using multiple methods and bases to describe the distribution of the GWB power on the sky. We do not find significant evidence of anisotropy, and place a Bayesian $95\%$ upper limit on the level of broadband anisotropy such that $(C_{l>0} / C_{l=0}) < 20\%$. We also derive conservative estimates on the anisotropy expected from a random distribution of SMBHB systems using astrophysical simulations conditioned on the isotropic GWB inferred in the 15-yr dataset, and show that this dataset has sufficient sensitivity to probe a large fraction of the predicted level of anisotropy. We end by highlighting the opportunities and challenges in searching for anisotropy in pulsar timing array data.
Mass spectrometry in structural and stereochemical problems. Absence of electron-impact induced methyl migration in 2,2,8,8-tetramethylnonan-5-one (1965)

R. R. Arndt and C. Djerassi, Chem. Commun. (London), 1965, 578 DOI: 10.1039/C19650000578
Adaptive proportional routing: a localized QoS routing approach (2002)

Most of the QoS routing schemes proposed so far require periodic exchange of QoS state information among routers, imposing both communication overhead on the network and processing overhead on core routers. Furthermore, stale QoS state information causes the performance of these QoS routing schemes to degrade drastically. In order to circumvent these problems, we focus on localized QoS routing schemes where the edge routers make routing decisions using only "local" information and thus reducing the overhead at core routers. We first describe virtual capacity-based routing (VCR), a theoretical scheme based on the notion of virtual capacity of a route. We then propose proportional sticky routing (PSR), an easily realizable approximation of VCR and analyze its performance. We demonstrate through extensive simulations that adaptive proportional routing is indeed a viable alternative to the global QoS routing approach.
Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice (2017)

Lung metastasis is the major cause of death in patients with triple negative breast cancer (TNBC), an aggressive subtype of breast cancer with no effective therapy at present. It has been proposed that dual-targeted therapy, ie, targeting chemotherapeutic agents to both tumor vasculature and cancer cells, may offer some advantages. The present work was aimed to develop a dual-targeted synergistic drug combination nanomedicine for the treatment of lung metastases of TNBC. Thus, Arg-Gly-Asp peptide (RGD)-conjugated, doxorubicin (DOX) and mitomycin C (MMC) co-loaded polymer-lipid hybrid nanoparticles (RGD-DMPLN) were prepared and characterized. The synergism between DOX and MMC and the effect of RGD-DMPLN on cell morphology and cell viability were evaluated in human MDA-MB-231 cells in vitro. The optimal RGD density on nanoparticles (NPs) was identified based on the biodistribution and tumor accumulation of the NPs in a murine lung metastatic model of MDA-MB-231 cells. The microscopic distribution of RGD-conjugated NPs in lung metastases was examined using confocal microscopy. The anticancer efficacy of RGD-DMPLN was investigated in the lung metastatic model. A synergistic ratio of DOX and MMC was found in the MDA-MB-231 human TNBC cells. RGD-DMPLN induced morphological changes and enhanced cytotoxicity in vitro. NPs with a median RGD density showed the highest accumulation in lung metastases by targeting both tumor vasculature and cancer cells. Compared to free drugs, RGD-DMPLN exhibited significantly low toxicity to the host, liver and heart. Compared to non-targeted DMPLN or free drugs, administration of RGD-DMPLN (10 mg/kg, iv) resulted in a 4.7-fold and 31-fold reduction in the burden of lung metastases measured by bioluminescence imaging, a 2.4-fold and 4.0-fold reduction in the lung metastasis area index, and a 35% and 57% longer median survival time, respectively. Dual-targeted RGD-DMPLN, with optimal RGD density, significantly inhibited the progression of lung metastasis and extended host survival.
Dihydrogen: a better ligand than water? IR and x-ray evidence for aquo coordination in W(CO)3(PR3)2(H2O), thermodynamics of H2O binding versus .eta.2-H2 binding and H2O/D2 isotopic exchange. Implications for the biological activation of hydrogen (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDihydrogen: a better ligand than water? IR and x-ray evidence for aquo coordination in W(CO)3(PR3)2(H2O), thermodynamics of H2O binding versus .eta.2-H2 binding and H2O/D2 isotopic exchange. Implications for the biological activation of hydrogenGregroy J. Kubas, Carol J. Burns, Guru Rattan K. Khalsa, Lori Stepan Van Der Sluys, Gabor Kiss, and Carl D. HoffCite this: Organometallics 1992, 11, 10, 3390–3404Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/om00046a044https://doi.org/10.1021/om00046a044research-articleACS PublicationsRequest reuse permissionsArticle Views323Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts