gebhart/patrepeval huggingface dataset:
Treatment on 97 cases of psychological erectile dysfunction with combined Chinese and western medicine (2010)

Objectives:To explore and analyze the therapeutic effects of integrated Chinese and western medicine on psychological ED. Methods: One hundred and Ninety-five Psychological ED patients were randomly divided into the treatment group (97 cases) and the control group(98 cases). The control group was treated with psychological and behavioral therapy, supplemented with western medicine, while the treatment group received further treatment with traditional Chinese medicine-Zhuangyao Cendiwan pills in addition to all the therapies used in the control group. The therapeutic effects were observed after three months of treatment. Results: The therapeutic effects in treatment group is significantly higher than that in the control group(P0.05). Conclusion: Integrated Chinese and western medicine have significant effects on the treatment of psychological ED, and its practice in clinics should be promoted.
The<i>tip-E</i>Mutation of<i>Drosophila</i>Decreases Saxitoxin Binding and Interacts with Other Mutations Affecting Nerve Membrane Excitability (1986)

A recessive temperature-sensitive paralytic mutation, tip-E, is associated with reduced binding of [3H]saxitoxin to voltage-sensitive sodium channels in membranes from adult Drosophila heads. There is a decrease of 30-40% in the number of [3H]saxitoxin-binding sites per mg protein (Bmax), but the dissociation constant (Kd) for [3H]saxitoxin binding is normal in the remaining population of binding sites. This decrease is not due to a general hypotrophy of neural tissue since the number of alpha-bungarotoxin binding sites is normal in tip-E mutants. Although saxitoxin binding is reduced in vitro, pharmacological experiments suggest that tip-E mutants have close to the wild-type number of sodium channels in vivo. This suggestion is supported by the observation that at permissive temperatures tip-E only marginally suppresses a mutation which causes enhanced membrane excitability. However, even at permissive temperatures tip-E interacts synergistically with mutations that decrease membrane excitability. In this case, the double mutants exhibit reduced viability and/or longevity. We postulate that either the structure of sodium channels or their microenvironment is altered in tip-E mutants resulting in an increased liability of binding sites in vitro.
Escherichia coli Bacteriocins: Antimicrobial Efficacy and Prevalence among Isolates from Patients with Bacteraemia (2011)

Bacteriocins are antimicrobial peptides generally active against bacteria closely related to the producer. Escherichia coli produces two types of bacteriocins, colicins and microcins. The in vitro efficacy of isolated colicins E1, E6, E7, K and M, was assessed against Escherichia coli strains from patients with bacteraemia of urinary tract origin. Colicin E7 was most effective, as only 13% of the tested strains were resistant. On the other hand, 32%, 33%, 43% and 53% of the tested strains exhibited resistance to colicins E6, K, M and E1. Moreover, the inhibitory activity of individual colicins E1, E6, E7, K and M and combinations of colicins K, M, E7 and E1, E6, E7, K, M were followed in liquid broth for 24 hours. Resistance against individual colicins developed after 9 hours of treatment. On the contrary, resistance development against the combined action of 5 colicins was not observed. One hundred and five E. coli strains from patients with bacteraemia were screened by PCR for the presence of 5 colicins and 7 microcins. Sixty-six percent of the strains encoded at least one bacteriocin, 43% one or more colicins, and 54% one or more microcins. Microcins were found to co-occur with toxins, siderophores, adhesins and with the Toll/Interleukin-1 receptor domain-containing protein involved in suppression of innate immunity, and were significantly more prevalent among strains from non-immunocompromised patients. In addition, microcins were highly prevalent among non-multidrug-resistant strains compared to multidrug-resistant strains. Our results indicate that microcins contribute to virulence of E. coli instigating bacteraemia of urinary tract origin.
4Ps medicine of the fatty liver: the research model of predictive, preventive, personalized and participatory medicine—recommendations for facing obesity, fatty liver and fibrosis epidemics (2014)

Relationship between adipose tissue and fatty liver, and its possible evolution in fibrosis, is supported by clinical and research experience. Given the multifactorial pathogenesis of non-alcoholic fatty liver disease (NAFLD), treatments for various contributory risk factors have been proposed; however, there is no single validated therapy or drug association recommended for all cases which can stand alone. Mechanisms, diagnostics, prevention and treatment of obesity, fatty liver and insulin resistance are displayed along with recommendations and position points. Evidences and practice can get sustainable and cost-benefit valuable outcomes by participatory interventions. These recommendations can be enhanced by comprehensive research projects, addressed to societal issues and innovation, market appeal and industry development, cultural acceptance and sustainability. The basis of participatory medicine is a greater widespread awareness of a condition which is both a disease and an easy documented and inclusive clue for associated diseases and unhealthy lifestyle. This model is suitable for addressing prevention and useful for monitoring improvement, worsening and adherence with non-invasive imaging tools which allow targeted approaches. The latter include health psychology and nutritional and physical exercise prescription expertise disseminated by continuous medical education but, more important, by concrete curricula for training undergraduate and postgraduate students. It is possible and recommended to do it by early formal teaching of ultrasound imaging procedures and of practical lifestyle intervention strategies, including approaches aimed to healthier fashion suggestions. Guidelines and requirements of research project funding calls should be addressed also to NAFLD and allied conditions and should encompass the goal of training by research and the inclusion of participatory medicine topics. A deeper awareness of ethics of competences in health professionals and the articulation of knowledge, expertise and skills of medical doctors, dieticians, health psychologists and sport and physical exercise graduates are the necessary strategy for detectin a suboptimal health status and achieving realistically beneficial lifestyle changes. "The devil has put a penalty on all things we enjoy in life. Either we suffer in health or we suffer in soul or we get fat" (Albert Einstein); the task of medical research and intervention is to make possible to enjoy life also without things that make sufferance in health and souls and which excessively increase body fat.
Manufacturing Solidarity: Adventure Training for Managers (1991)

The present study showed that nanocoating of titanium implants with pectin RG-Is did not significantly enhance bone healing and osseointegration when placed in rabbit tibia bone.
A geometrical approach to neural network design (1989)

A geometrical method for deriving the topology of a neural net is proposed. Instead of making use of learning algorithms, the pattern space is analyzed. The method is outlined for a neural net which performs a binary representation of an analog sensory input. This leads to a geometrical determination of the structure of the neural net, i.e. its layers, weights, and thresholds; no learning is necessary. It is shown that the number of layers and neurons in a feedforward MLP specialized to A/D conversion can be reduced considerably by introducing feedback. The geometrical approach turns out to provide various alternatives for the design of such a net. The results obtained strongly support the view that geometrical analysis of the pattern structure to be recognized helps avoid unnecessary learning.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Determinants and Value of Enterprise Risk Management: Empirical Evidence From the Literature (2015)

Abstract The development of an enterprise risk management (ERM) program enables companies to manage corporate risks in a holistic manner as opposed to the silo‐based perspective in traditional risk management frameworks. One main question in this regard is what factors drive the implementation of an ERM system in companies and whether ERM programs can actually create value once implemented. This article addresses these questions by conducting a comparative assessment of empirical evidence from the literature regarding the determinants of ERM and its value once implemented. In doing so we are able to illustrate differences in model specifications and the underlying data. Our literature study shows that particularly the company size and the level of institutional ownership are significantly positively related to the implementation of ERM in most empirical studies and, furthermore, that ERM generally has a (significant) positive impact on corporate value and performance (to a different extent and depending on the focus of the studies). However, geographic and/or industrial restrictions regarding the underlying data sets partly limit the generalization of the empirical results.
Effects of exogenous ABA application on post-anthesis dry matter redistribution and grain starch accumulation of winter wheat with different staygreen characteristics (2014)

The objective of this study was to investigate whether and how exogenous abscisic acid (ABA) is involved in mediating starch accumulation in the grain and redistribution of carbohydrates during grain filling of two wheat cultivars with different staygreen characteristics. At blooming stage, plants of Wennong 6 (a staygreen cultivar) and Jimai 20 (control) were sprayed with 10 mg L− 1 abscisic acid (ABA) for 3 days. The application of ABA significantly (P < 0.05) increased grain filling rate, starch accumulation rate and content, remobilization of dry matters to kernels, and 1000-grain weight of the two cultivars. Exogenous ABA markedly (P < 0.05) increased grain yield at maturity, and Wennong 6 and Jiami 20 showed 14.14% and 4.86% higher compared yield than the control. Dry matter accumulation after anthesis of Wennong 6 was also significantly (P < 0.05) influenced by exogenous ABA, whereas that of Jimai 20 was unchanged. Application of ABA increased endogenous zeatin riboside (ZR) content 7 days after anthesis (DAA), and spraying ABA significantly increased endogenous indole-3-acetic acid (IAA) and ABA contents from 7 to 21 DAA and decreased gibberellin (GA3) content at 14 DAA, but increased GA3 content from 21 to 35 DAA. The results suggested that increased yield of staygreen was due to greater starch assimilation owing to a higher filling rate and longer grain-filling duration.
High convergence, indirect drive inertial confinement fusion experiments at Nova (1996)

High convergence, indirect drive implosion experiments have been done at the Nova Laser Facility. The targets were deuterium and deuterium/tritium filled, glass microballoons driven symmetrically by x rays produced in a surrounding uranium hohlraum. Implosions achieved convergence ratios of 24:1 with fuel densities of 19 g/cm3; this is equivalent to the range required for the hot spot of ignition scale capsules. The implosions used a shaped drive and were well characterized by a variety of laser and target measurements. The primary measurement was the fuel density using the secondary neutron technique (neutrons from the reaction 2H(3H,n)4He in initially pure deuterium fuel). Laser measurements include power, energy and pointing. Simultaneous measurement of neutron yield, fusion reaction rate, and x‐ray images provide additional information about the implosion process. Computer models are in good agreement with measurement results.
Tahivilla: propiedad de los campesinos (1997)

E n el transcurrir de los anos, la colonizacion de Tahivilla se llevo a cabo en varias etapas, dependiendo siempre, como es normal, de los acontecimientos historicos que iban marcando la propia historia de Espana. Dicho esto, podemos distinguir cuatro fases: 1.Durante la II Republica, en la que comienza su andadura. Se trataba de implantar de manera eficaz, pero sin exito alguno, la Reforma Agraria con la cual la finca Tahivilla es expropiada. 2.Durante el periodo de la Guerra Civil Espanola, en la que se viven momentos de incertidumbre. 3.Durante el Regimen de Franco, en la que la politica agraria sirve de propaganda del Regimen, de la cual salio beneficiada Tahivilla. Dentro de esta fase, la mas larga, podemos distinguir dos periodos: uno primero de Aparceria con el I.N.C. y otro segundo de Acceso a la Propiedad. 4.Durante la Democracia. Fase en la que se produce la adquisicion definitiva de las tierras por parte de los colonos. Seguidamente analizaremos cada una con mas detenimiento.
Supply Chain Management Holistic (2011)

This chapter contains sections titled: The Relevance of SCM to Pharmaceuticals Production Systems and the SCM Holistic The Core of SCM First Principle of SCM Supply Chains as a Series of Interconnected Systems Processes to Manage the Supply Chain A Word About Processes How the SCM Processes Should Mesh Together Production and Inventory Control Strategic Procurement Transportation, Storage, and Distribution Information Systems and Technology Improvement
The isolation, purification and some properties of pheromaxein, the pheromonal steroid-binding protein, in porcine submaxillary glands and saliva (1988)

Pheromaxein, the 16-androstene steroid-binding protein with a relative molecular mass of 15,000 was isolated in sub-milligram quantities from the submaxillary gland and saliva of the Gottingen miniature boar, after a fourfold purification involving the following methods: ultrafiltration for submaxillary gland cytosols and ethanol precipitation for saliva, Concanavalin-A-Sepharose affinity chromatography, sodium dodecyl sulphate polyacrylamide gel electrophoresis, 'Extractigel-D' affinity chromatography (to remove sodium dodecyl sulphate) and fast protein-liquid chromatography. Yields of purified pheromaxein obtained after fast protein-liquid chromatography represented 10-20% of total protein present in an ultrafiltrate of a submaxillary gland cytosol. Fast protein-liquid chromatography separated the alpha- and beta-charge isomers of pheromaxein which were shown to have isoelectric points of 4.78 and 5.35 respectively on flat-bed isoelectric focusing. Some data are provided for the variable occurrence of the isomeric forms of pheromaxein in relation to different breeds of pig. Five 16-unsaturated steroids showed the highest binding to pheromaxein. Other steroids of the 5 alpha- and 5 beta-androstane series also showed some binding to pheromaxein, i.e. 17 beta-hydroxy-5 alpha-androstan-3-one (19.2%), with 5 alpha-androstan-3-one, which has a similar urinous odour to 5 alpha-androst-16-en-3-one, showing the greatest binding (42.6%) relative to 5 alpha-androst-16-en-3-one (100%).
Increased Portion Size Leads to Increased Energy Intake in a Restaurant Meal (2004)

In a restaurant setting, increasing the size of an entrée results in increased energy intake. These results support the suggestion that large restaurant portions may be contributing to the obesity epidemic.
Remote sounding of atmospheric temperature from satellites V. The pressure modulator radiometer for Nimbus F (1974)

Abstract A new radiometer is described for remote sounding of the temperature of the stratosphere and mesosphere (40-90 km) from a satellite platform. In order to select radiation emitted from close to the centres of CO2 lines in the 15 pm infrared band, included in the optical system is a cell containing CO2 gas whose pressure can be modulated at a frequency of ca. 15 Hz. The parts of the emission lines selected can be altered by two methods known as pressure scanning and Doppler scanning. A two-channel instrument for the Nimbus F satellite is described in detail.
ESD-induced degradation of vertical-cavity surface-emittinglasers (2000)

The sensitivity of proton implanted, vertical-cavity surface-emitting lasers (VCSELs) to electrostatic discharge (ESD) pulses is investigated under human body model test conditions. Rather low degradation threshold pulse amplitudes were observed in forward bias (+1500 V) as well as reverse bias (–800 V) step stress tests. Monitoring both the electrical and optical parameters of the VCSELs during ESD stress, it was found that in forward bias ESD stress tests the optical degradation precedes the electrical degradation.
Multi-level acoustic segmentation of continuous speech (2003)

As part of the goal to better understand the relationship between the speech signal and the underlying phonemic representation, the authors have developed a procedure that describes the acoustic structure of the signal. Acoustic events are embedded in a multi-level structure in which information ranging from coarse to fine is represented in an organized fashion. An analysis of the acoustic structure, using 500 utterances from 100 different talkers, show that it captures over 96% of the acoustic-phonetic events of interest with an insertion rate of less than 5%. The signal representation, and the algorithms for determining the acoustic segments and the multi-level structure are described. Performance results and a comparison with scale-space filtering is also included. Possible use of this segmental description for automatic speech recognition is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Targeted CGRP Small Molecule Antagonists for Acute Migraine Therapy (2018)

Migraine is a highly prevalent, severe, and disabling neurological condition with a significant unmet need for effective acute therapies. Patients (~50%) are dissatisfied with their currently available therapies. Calcitonin gene-related peptide (CGRP) has emerged as a key neuropeptide involved in the pathophysiology of migraines. As reviewed in this manuscript, a number of small molecule antagonists of the CGRP receptor have been developed for migraine therapy. Incredibly, the majority of the clinical trials conducted have proven positive, demonstrating the importance of this signalling pathway in migraine. Unfortunately, a number of these molecules raised liver toxicity concerns when used daily for as little as 7 days resulting in their discontinuation. Despite the clear safety concerns, clinical trial data suggests that their intermittent use remains a viable and safe alternative, with 2 molecules remaining in clinical development (ubrogepant and rimegepant). Further, these proofs of principle studies identifying CGRP as a viable clinical target have led to the development of several CGRP or CGRP receptor-targeted monoclonal antibodies that continue to show good clinical efficacy.
Thermal decomposition of endrin as a measure of surface activity of gas chromatographic support media (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal decomposition of endrin as a measure of surface activity of gas chromatographic support mediaHerbert L. MacDonell and David L. EatonCite this: Anal. Chem. 1968, 40, 10, 1453–1455Publication Date (Print):August 1, 1968Publication History Published online1 May 2002Published inissue 1 August 1968https://pubs.acs.org/doi/10.1021/ac60266a016https://doi.org/10.1021/ac60266a016research-articleACS PublicationsRequest reuse permissionsArticle Views47Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Inhalation Toxicity of Pyrolysis Products of Polytetrafluoroethylene Heated Below 500 Degrees Centigrade (1968)

Abstract Quantitative evidence has been obtained which indicates that the principal toxic component in the pyrolysate from PTFE (Teflon® 5)∗ at the first temperature at which rat mortality is observed (Approximate Lethal Temperature, ALT), is a particulate material which may have other toxicants adsorbed on it. The toxicity of this particulate varies, depending upon the conditions under which it is generated. At 30°C above the ALT, perfluoroisobutylene could be the principal toxic agent. The data correlate well with known chemical reactions as well as observations and hypotheses of other investigators.
Data Center Management Plan in Cloud Computing Environment (2010)

Cloud computing environment is a new IT service model to support large-scale computing resources of virtualization, on-demand computing, dynamic deployment and flexible scalability. Cloud computing architecture has fore levels. First level is SaaS (Software as Service). The following layer is PaaS (Platform as a service). The third layer is IaaS (Infrastructure as a service). The bottom layer is IT infrastructure (IT Foundation). Cloud computing has dynamic, flexible, elastic, on-demand computing features. It makes particularly suitable for complex and volatile economic environment.
Data analysis in qualitative research: a brief guide to using nvivo. (2008)

Qualitative data is often subjective, rich, and consists of in-depth information normally presented in the form of words. Analysing qualitative data entails reading a large amount of transcripts looking for similarities or differences, and subsequently finding themes and developing categories. Traditionally, researchers ‘cut and paste’ and use coloured pens to categorise data. Recently, the use of software specifically designed for qualitative data management greatly reduces technical sophistication and eases the laborious task, thus making the process relatively easier. A number of computer software packages has been developed to mechanise this ‘coding’ process as well as to search and retrieve data. This paper illustrates the ways in which NVivo can be used in the qualitative data analysis process. The basic features and primary tools of NVivo which assist qualitative researchers in managing and analysing their data are described.