gebhart/patrepeval huggingface dataset:
Shape Memory Polymers for Active Cell Culture (2011)

Shape memory polymers (SMPs) are a class of "smart" materials that have the ability to change from a fixed, temporary shape to a pre-determined permanent shape upon the application of a stimulus such as heat(1-5). In a typical shape memory cycle, the SMP is first deformed at an elevated temperature that is higher than its transition temperature, T(trans;) [either the melting temperature (T(m;)) or the glass transition temperature (T(g;))]. The deformation is elastic in nature and mainly leads to a reduction in conformational entropy of the constituent network chains (following the rubber elasticity theory). The deformed SMP is then cooled to a temperature below its T(trans;) while maintaining the external strain or stress constant. During cooling, the material transitions to a more rigid state (semi-crystalline or glassy), which kinetically traps or "freezes" the material in this low-entropy state leading to macroscopic shape fixing. Shape recovery is triggered by continuously heating the material through T(trans;) under a stress-free (unconstrained) condition. By allowing the network chains (with regained mobility) to relax to their thermodynamically favored, maximal-entropy state, the material changes from the temporary shape to the permanent shape. Cells are capable of surveying the mechanical properties of their surrounding environment(6). The mechanisms through which mechanical interactions between cells and their physical environment control cell behavior are areas of active research. Substrates of defined topography have emerged as powerful tools in the investigation of these mechanisms. Mesoscale, microscale, and nanoscale patterns of substrate topography have been shown to direct cell alignment, cell adhesion, and cell traction forces(7-14). These findings have underscored the potential for substrate topography to control and assay the mechanical interactions between cells and their physical environment during cell culture, but the substrates used to date have generally been passive and could not be programmed to change significantly during culture. This physical stasis has limited the potential of topographic substrates to control cells in culture. Here, active cell culture (ACC) SMP substrates are introduced that employ surface shape memory to provide programmed control of substrate topography and deformation. These substrates demonstrate the ability to transition from a temporary grooved topography to a second, nearly flat memorized topography. This change in topography can be used to control cell behavior under standard cell culture conditions.
The benefit of directly comparing autism and schizophrenia for revealing mechanisms of social cognitive impairment (2010)

Autism and schizophrenia share a history of diagnostic conflation that was not definitively resolved until the publication of the DSM-III in 1980. Though now recognized as heterogeneous disorders with distinct developmental trajectories and dissociative features, much of the early nosological confusion stemmed from apparent overlap in certain areas of social dysfunction. In more recent years, separate but substantial literatures have accumulated for autism and schizophrenia demonstrating that abnormalities in social cognition directly contribute to the characteristic social deficits of both disorders. The current paper argues that direct comparison of social cognitive impairment can highlight shared and divergent mechanisms underlying pathways to social dysfunction, a process that can provide significant clinical benefit by informing the development of tailored treatment efforts. Thus, while the history of diagnostic conflation between autism and schizophrenia may have originated in similarities in social dysfunction, the goal of direct comparisons is not to conflate them once again but rather to reveal distinctions that illuminate disorder-specific mechanisms and pathways that contribute to social cognitive impairment.
Measuring component DGD by using polarized ASE noise and monitoring the degree of polarization (2004)

We demonstrate a novel technique for measuring the first and second order PMD of in-line components and PMD emulators by scrambling a narrow band ASE noise source. We show that the PMD is related to the minimum and maximum DOP.
Observation of plasmon-phonons in a metamaterial superconductor using inelastic neutron scattering (2019)

A metamaterial approach is capable of drastically increasing the critical temperature, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow> <mml:mrow><mml:mi>c</mml:mi></mml:mrow> </mml:msub> </mml:math> , of composite metal-dielectric superconductors as demonstrated by the tripling of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow> <mml:mrow><mml:mi>c</mml:mi></mml:mrow> </mml:msub> </mml:math> that was observed in bulk Al-Al<sub>2</sub>O<sub>3</sub> coreshell metamaterials. A theoretical model based on the Maxwell-Garnett approximation provides a microscopic explanation of this effect in terms of electron-electron pairing mediated by a hybrid plasmon-phonon excitation. We report an observation of this excitation in Al-Al<sub>2</sub>O<sub>3</sub> core-shell metamaterials using inelastic neutron scattering. This result provides support for this mechanism of superconductivity in metamaterials.
294. The oxidation of monoethenoid fatty acids and esters. The preparation and catalytic oxidation of highly purified brassidic acid by gaseous oxygen (1953)

J. H. Skellon and C. G. Taylor, J. Chem. Soc., 1953, 1433 DOI: 10.1039/JR9530001433
Reassembly self-sorting triggered by heterodimerization (2011)

We report herein a five-component self-sorted system comprising molecular clips that form heterodimers 1·4 and 8·11, and homodimer 14·14 in C(6)D(5)CD(3)/CDCl(3). The three component self-sorting mixture comprising 1·1, 8·8, and 14·14 undergoes triggered reassembly self-sorting upon addition of 4·4 and 11·11.
Nanocrystallization of Insoluble Copper(I) Complex and Formation Mechanism (2015)

We have successfully fabricated insoluble copper(I) complex [Cu(μ-I)dppet]2 nanocrystals by developing the heterogeneous reaction process between rod-like nanocrystals of dppet ligand prepared in advance and added acetonitrile solution of copper(I) halide. During this reaction process, the shape of dppet ligand nanocrystals was dramatically changed from rod-like to spherical. Probably, the complexation reaction and subsequent nanocrystallization would proceed on or near swollen surface of dppet nanocrystals in acetonitrile droplet as restricted reaction field.
Improvements about automatic lay-panning for irregular shapes on plain fabric (2002)

This paper deals with in optimal allocation of irregular shapes on a single sheet. The proposed algorithm is particularly adapted to optimize the layout of pieces of clothes in garment industry. The characteristics reached by this algorithm allow to fit it in a flexible continuous cutting frame. After a remind of our shapes description device, we present the problem modelling through the tree of possible states. The search of a sub-optimal way in the state space representation is carried out with /spl epsi/-admissible algorithm: A/spl epsi/. The last one has been modified in order to provide a better solution in the same time. The principle is to yield an initial solution, and then to prune the tree in removing the generated nodes of which estimated cost is more than the last higher bound. The higher bound is processed either by the initial solution, or by the last best solution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Induction of c‐fos and TIS genes in cultured rat astrocytes by neurotransmitters (1989)

The interaction of neurotransmitters with their specific receptors initiates a cascade of intracellular biochemical events which lead to induction of specific genes. Included in this cascade is the rapid and transient induction of a family of primary early response genes we term TIS genes (Lim et al.: Oncogene 1: 263-270, 1987). Expression of six TIS gene, including c-fos, was examined in secondary cultures of rat neocortical astrocytes exposed to muscarinic and adrenergic agonists and antagonists to study the early genomic responses which accompany neurotransmitter-induced alteration of glial morphology and physiology. Carbachol induced accumulation of mRNA for c-fos and the other TIS genes. Carbachol-mediated induction of TIS mRNA expression was sensitive to atropine blockade and was potentiated by lithium. Norepinephrine (NE), isoproterenol, or phenylephrine also induced TIS mRNA accumulation. In order to determine which second-messenger pathways mediate NE induction of TIS gene expression, the influences of the beta(B) antagonist propranolol (PR), the alpha I(AI) antagonist prazosin (PZ), and the alpha 2(A2) antagonist yohimbine (YB) were examined. The induction of TIS1 mRNA by NE was partially blocked by PR or PZ alone, and completely abolished by both antagonists in combination. YB had no effect on TIS1 mRNA expression. These results suggest that NE induces TIS1 mRNA through both B- and A 1-adrenergic, but not A2, pathways. The lack of effect of inhibitors of phospholipase A2 and cyclooxygenase suggests that the A1 component is mediated through a protein kinase C pathway. The induction of transient gene expression by neurotransmitters may mediate the secondary genomic responses and phenotypic changes occurring in astrocytes in response to alterations in neuronal neurotransmitter release.
Nuclear Reaction Analysis of Hydrogen in Metals. (1986)

Abstract : Research accomplishments of a contract to utilize nuclear reaction analysis to study hydrogen in materials are summarized. These include development of new techniques (high sensitivity, non-vacuum, Doppler spectroscopy, superlattice...), the application of these techniques to study stress and electric current effects on hydrogen distribution in metals and the application of these methods to a variety of new materials. The papers prepared under this contract can be grouped under four headings: I) Development of new techniques for study of hydrogen in materials, II) Studies of how macroscopic variables (stress and electric currents) effect the distribution of hydrogen in metals, III) Studies of the effects of hydrogen in various new thin film materials, and IV) Reviews.
Results of Unrelated Cord Blood Transplant in Fanconi Anemia Patients: Risk Factor Analysis for Engraftment and Survival (2007)

We retrospectively analyzed results of unrelated cord blood transplantation (UCBT) in 93 Fanconi anemia (FA) patients. Median age at transplantation was 8.6 years (1-45). The units transplanted were HLA-A, -B, or -DRB1 identical in 12 cases, 1 HLA mismatch in 35 cases, and 2 or 3 HLA differences in 45 cases. The median number of nucleated cells (NC) and CD34+ cells infused of recipient weight was 4.9x10(7)/kg and 1.9x10(5)/kg, respectively. Participating centers selected the preparative regimen of their choice, in 57 patients (61%), it included Fludarabine. Graft-versus-host disease (GVHD) prophylaxis consisted mostly of cyclosporine with prednisone. Cumulative incidence (CI) of neutrophil recovery was 60+/-5% at day +60. In multivariate analysis, Fludarabine containing regimen and NC infused>or=4.9x10(7)/kg were associated with higher probability of recovery. CI of grade II-IV acute and of chronic GVHD (aGVHD, cGVHD) was 32%+/-5% and 16%+/-4%, respectively. Overall survival (OS) was 40%+/-5%. In multivariate analysis, factors associated with favorable outcome were use of Fludarabine in the conditioning regimen, number of NC infused>or=4.9x10(7)/kg, and negative cytomegalovirus (CMV) serology in the recipient. In conclusion, factors easily modifiable such as donor selection and a Fludarabine-containing regimen can considerably improve survival in FA patients given a UCBT. These data are the basis for designing prospective protocols.
Award of the Tribunal of Arbitration Constituted Under the Treaty Concluded at Washington, the 29th of February, 1892, between the United States of America and her Majesty the Queen of the United Kingdom of Great Britain and Ireland (1912)

Award of the Tribunal of Arbitration Constituted Under the Treaty Concluded at Washington, the 29th of February, 1892, between the United States of America and her Majesty the Queen of the United Kingdom of Great Britain and Ireland - Volume 6 Issue 1
Fermentation Microbiology and Biotechnology, Fourth Edition (2018)

International audience
Structural comparison between retro-inverso and parent peptides: Molecular basis for the biological activity of a retro-inverso analogue of the immunodominant fragment of VP1 coat protein from foot-and-mouth disease virus (1997)

Antibodies induced against intact foot-and-mouth disease Virus (FMDV) particles bind to the retro-inverso analogue of fragment 141-159 of the viral coat protein VP1 of FMDV, variant A, equally well as to the parent peptide. A conformational investigation of this retro-inverso peptide was carried out by nmr spectroscopy and restrained molecular modeling in order to identify the structural basis for the antigenic mimicry between these retro-inverso and parent peptides. In 100% trifluoroethanol a well-defined left-handed alpha-helical region exists from residue 150 to residue 159, which is consistently present in all conformational families obtained from restrained modelling. A less-defined left-handed helical region is present in the tract 144-148, which is also consistent for all structures. Conformational flexibility exists about Gly149, which leads to two types of structures, either bent or linear. In the bent structures, a three-residue inverse tight turn is found, which can be classified as an inverse gamma-turn centered at Gly149. The overall structural features of the retro-inverso peptide are shown to be similar to those of the parent L-peptide. The two molecules, however, are roughly mirror images because they share inherently chiral secondary structure elements. By comparing these conformational conclusions with the x-ray structure of the Fab complex of a corresponding VP1 antigenic fragment, a rationale is proposed to account for the topological requirements of specific recognition that are implied by the equivalent antigenic activity of the natural and retro-inverso compounds.
Increasing robustness of an audio watermark using turbo codes (2003)

Standard spread spectrum audio watermarking algorithms offer BER unacceptable for reliable transmission of data. Causes of unreliable watermark detection are often attacks that distort the watermarked audio in fading-like manner, disabling the correlation-based detectors to extract data. In this paper, consideration of capacity of the audio watermark channel in the presence of fading-like distortion is performed. It is shown that turbo codes offer convenient trade-off between capacity of the watermark channel and BER due to large coding gain in fading environment. Test results proved a large advantage of the proposed algorithm over standard detection as robustness is significantly increased for a given watermark data rate.
Performance characteristics of a half‐bridge type series resonant dc‐dc converter with auxiliary switches (1999)

Series resonant dc-dc converters possess the advantage of high efficiency for a relatively wide load range because their circulating energy is small. However, it is often observed that the switching frequency varies greatly when the input voltage and load current change, and in particular that the switching frequency enters the audible frequency range when the load current decreases. A half-bridge type series resonant dc-dc converter with auxiliary switches has been designed in order to prevent this lowering of the switching frequency under light load conditions. This paper analyses the performance characteristics of a half-bridge type series resonant dc-dc converter with auxiliary switches, including operation of the control circuit. The relationship among the circuit parameters, the operation modes, and output characteristics is clarified, and the regulation mechanism of the output voltage is defined. © 1998 Scripta Technica, Electron Comm Jpn Pt 1, 82(2): 74–81, 1999
Urinary S100A1B and S100BB to predict hypoxic ischemic encephalopathy at term (2009)

Urinary S100A1B and S100BB were measured to detect cases at risk of hypoxic-ischemic encephalopathy (HIE) in asphyxiated newborns. We recruited 42 asphyxiated infants and 63 healthy term neonates. S100A1B and S100BB were measured at first urination (time 0) and at 4 (time 1), 8 (time 2), 12 (time 3), 16 (time 4), 20 (time 5), 24 (time 6), 72 (time 7) hours after birth. 20 infants had no/mild HIE with good prognosis (Group A) and 22 had moderate/severe HIE with a greater risk of neurological handicap (Group B). Urine S100A1B and S100BB levels were significantly (P less than 0.0.01, for all) higher at all monitoring time-points in Group B than Group A and controls, but not between Group A and controls. Both S100A1B and S100BB have great sensitivity and specificity for HIE since their first measurement. In conclusion, S100A1B and S100BB are increased in urine collected from asphyxiated newborns who will develop HIE since first urination, and their measurement may be useful to early predict HIE when monitoring procedures are still of no avail.
The impact of body composition on vertebral fractures during aromatase inhibitors therapy: A cross-sectional study. (2018)

e12504 Background: Aromatase-inhibitors (AIs) decrease the bone mineral density (BMD) and increase the risk of clinical fractures but the mechanism underlying the increased fracture risk (FR) is not fully elucidated. In healthy post menopausal women obesity is associated with lower FR due the protective effect of elevated estrogen levels. However this mechanism cannot be extended to AI treated pts since estrogens are deeply inhibited. We designed a cross sectional study to explore the effect of Fat body mass (FBM) on the risk of morphometric vertebral fracture (VF) in postmenopausal estrogen receptor positive breast carcinoma (BC) submitted to adjuvant AI therapy. Methods: From October 2013 to May 2017 315 EBC patients (pts) were recruited. All pts underwent a dual-energy X-ray absorptiometry (DXA) for the assessment of BMD, morphometric evaluation of VFs and body composition at baseline and after at least one year of AI therapy. Results: 187 pts were AI naive and 128 AI treated, and the prevalence of VFs was 21,9% and 31.2%, respectively. VFs in AI naïve pts were associated with older age (68 vs 62 years, p = 0.000) and lower BMD values at femoral neck (0.656 vs 0.698 gr/cm2, p = 0.02). Conversely, they were associated with higher Body Mass Index (27.26 vs 24.97, p = 0,046) and Fat Body Mass (29296.6 vs 23605.6 g, p = 0,022) in AI-treated patients. Conclusions: A high prevalence of radiological VFs was detected in EBC pts on AIs. Contrary to expectation VFs were associated with BMI and FBM but not with BMD. These data suggest a major contribution of altered bone quality in the fracture risk in AI treated pts. Data on trabecular bone score (a parameter of bone quality) TBS will be available at the meeting
Structural Properties of the Acidification Products of Scandium Hydroxy Chloride Hydrate (2015)

The structural properties of a series of scandium inorganic acid derivatives were determined. The reaction of Sc(0) with concentrated aqueous hydrochloric acid led to the isolation of [(H2O)5Sc(μ-OH)]24Cl·2H2O (1). Compound 1 was modified with a series of inorganic acids (i.e., HNO3, H3PO4, and H2SO4) at room temperature and found to form {[(H2O)4Sc(κ(2)-NO3)(μ-OH)]NO3}2 (2a), [(H2O)4Sc(κ(2)-NO3)2]NO3·H2O (2b) (at reflux temperatures), {6[H][Sc(μ-PO4)(PO4)]6}n (3), and [H][Sc(μ3-SO4)2]·2H2O (4a). Additional organosulfonic acid derivatives were investigated, including tosylic acid (H-OTs) to yield {[(H2O)4Sc(OTs)2]OTs}·2H2O (4b) in H2O and [(DMSO)3Sc(OTs)3] (4c) in dimethyl sulfoxide and triflic acid (H-OTf) to form [Sc(H2O)8]OTf3 (4d). Other organic acid modifications of 1 were also investigated, and the final structures were determined to be {([(H2O)2Sc(μ-OAc)2]Cl)6}n (5) from acetic acid (H-OAc) and [Sc(μ-TFA)3Sc(μ-TFA)3]n (6) from trifluoroacetic acid (H-TFA). In addition to single-crystal X-ray structures, the compounds were identified by solid-state and solution-state (45)Sc nuclear magnetic resonance spectroscopic studies.
Cytostatic and cytolytic effects of human recombinant tumor necrosis factor on human renal cell carcinoma cell lines derived from a single surgical specimen. (1987)

The purpose of this study was to determine whether human tumor cell lines derived from a single tumor exhibit heterogeneous responses to the anti-tumor effects of human recombinant tumor necrosis factor (h-r-TNF). Several cell lines with different metastatic propensities have been established in culture from a single surgical specimen of a human renal cell carcinoma following different selection procedures in nude mice. The cell lines exhibited significant differences in in vitro susceptibilities to cytotoxic effects of TNF. Kinetic analysis of the interaction of TNF with susceptible renal carcinoma cells demonstrated that a short 30 min interaction of TNF with the cells is sufficient to produce significant lysis 72 hr later. One cycle of exposure of sensitive cells to h-r-TNF did not produce cells resistant to it, nor did the degree of sensitivity to h-r-TNF vary after one passage of the cells in nude mice. Tumor cell resistance to the effects of TNF did develop spontaneously after prolonged cultivation in culture. We conclude that tumor cells derived from a single human renal cell carcinoma exhibit a heterogeneous response to the cytotoxic effects of h-r-TNF.
High- and low-potential flavin mimics. 2. 3,7,10-Trimethyl-(1H,3H,5H,7H,9H,10H)-pyrimido[5,4-g]pteridine-2,4,6,8-tetrone dianion reduction of carbonyl, nicotinamides, and alkyl disulfide functional groups (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh- and low-potential flavin mimics. 2. 3,7,10-Trimethyl-(1H,3H,5H,7H,9H,10H)-pyrimido[5,4-g]pteridine-2,4,6,8-tetrone dianion reduction of carbonyl, nicotinamides, and alkyl disulfide functional groupsEdward B. Skibo and Thomas C. BruiceCite this: J. Am. Chem. Soc. 1983, 105, 10, 3316–3328Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 May 1983https://pubs.acs.org/doi/10.1021/ja00348a059https://doi.org/10.1021/ja00348a059research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts