gebhart/patrepeval huggingface dataset:
Analogs of Tubercidin (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalogs of TubercidinJohn A. Montgomery and Kathleen. HewsonCite this: J. Med. Chem. 1967, 10, 4, 665–667Publication Date (Print):July 1, 1967Publication History Published online1 May 2002Published inissue 1 July 1967https://pubs.acs.org/doi/10.1021/jm00316a032https://doi.org/10.1021/jm00316a032research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reintroduction of gluten in adults and children with treated coeliac disease. (1979)

Twenty-eight patients, thought to have coeliac disease and on gluten free diets, were put on a normal diet to confirm their diagnoses. Nineteen had been diagnosed in adult life (ACD) and nine in childhood (CCD). Patients were assessed on jejunal, morphological, and symptomatic parameters. Eighteen patients with ACD relapsed within seven weeks. Nine patients with CCD relapsed at variable times but five took longer than seven weeks, the longest period beint 10 months. Seven patients had no symptoms despite morphological deterioration during challenge and one patient, with ACD, did not relapse and was HLA B8 negative. This patient with ACD had subtotal villous atrophy on two jejunal biopsies and later showed morphological improvement on a gluten free diet. There was no correlation between the relapse time and time spent on a gluten free diet.
Más allá de los límites del pensar discursivo. Notas sobre la figura del entendimiento intuitivo en la Crítica de la facultad de juzgar (2018)

The paper analyses the Kantian use of the notion of intuitive understanding as it appears in the third Critique. This analysis will highlight both problematic and fertility of this notion whose functions differ according to its systematic employment. In fact, according to the role that such understanding fulfills within the Kantian conceptual frame, it assumes different cognitive configurations, namely, (a) it shows that the principle of Zweckmäßigkeit is a valid transcendental presupposition only for our power of judgment, (b) it makes explicit that while purposiveness has just subjective validity, it is essential to understand specific natural beings; (c) it provides a model of synthetic totality which is accessible only trough the principle of purposiveness.
Long-wavelength negative mass instabilities in high current betatrons (1985)

Growth rates of negative mass instabilities in conventional and modified betatrons are calculated by analytic methods and by performing three-dimensional particle simulations. In contrast to earlier work, toroidal corrections to the field equations are included in the analytic model. As a result, good agreement with numerical simulations is obtained. The simulations show that the nonlinear development of the instabilities can seriously disrupt the beam.
Device modeling by radial basis functions (1992)

An alternative modeling technique that works directly from data and provides a straightforward and relatively automatic method of interpolating smoothly from measurements is presented. Since the results are nonexplicit (that is, the models are algorithmic rather than analytic), the approach is likely to be most appropriate in situations where it is difficult to derive an explicit functional form analogous to the Ebers-Moll equation for bipolar transistors. A good example is in the modeling of submicron devices in VLSI circuits, where the relevant device physics are currently poorly understood. >
Safety of Liposuction Using Exclusively Tumescent Local Anesthesia in 3,240 Consecutive Cases (2009)

Liposuction using exclusively TLA is a proven safe procedure provided that the existing guidelines are meticulously followed.
Computer-Aided Design of Microwave Parametric Frequency Dividers (2005)

A straightforward computer approach to the design of parametric frequency dividers using microwave diodes is presented. A detailed characterization of the nonlinear element together with a new optimization philosophy make an accurate nonlinear design of MIC dividers directly affordable.
English language placement testing at BYU-Hawaii in the time of COVID-19 (2020)

In this commentary, we describe the English language placement adaptations we were required to make due to the world-wide COVID-19 pandemic. It includes a brief description of our placement test battery which was adapted to address our institution's move to a remote teaching/learning mode. A discussion of the major challenges we experienced, their impacts, and how we addressed them is also included. Finally, we discuss what we have learned about the processes and how we will make further adaptations in future placement test administrations using a virtual platform.
The Application of Limited-Entry Techniques in Massive Hydraulic Fracturing Treatments (1987)

ABSTRACT Application of the limited entry-technique has been extended to massive hydraulic fracturing (MHF) of low permeability formations, such as the Niobrara and Codell intervals of the DJ Basin. Analysis of the bottomhole pressure data of these treatments indicates that proppant alters the mechanical configuration of the perforations, as evidenced by a change in the magnitude of perforation friction in opposition to the Bernoulli constant energy equation. The practical significance of changing pressure drop across perforations in limited entry stimulation treatments is that it alters treatment fluid distribution and injection rate profiles among the multiple intervals. This can result in zonal shut-off due to insufficient pressure drop (i.e., zone fracture pressure&gt; wellbore pressure) or zonal sand-out due to inadequate pad volumes and/or treating rate. This paper investigates the mechanisms involved in fluid and slurry flow through perforations. Fluid mechanics research and experimental laboratory and field testing are referenced. The effect of proppant on perforation friction is calibrated. Limited entry design and procedural guidelines for large scale fracturing treatments are presented to assist in achieving the desired placement of fluid and proppant into individual zones. Fundamental limitations of the limited entry technique in MHF applications are also discussed.
An integrated transport technique for circuit and packet switched traffic (2003)

An approach to achieving integrated transmission of packet and circuit traffic is proposed. Starting with dynamic time-division multiplexing (DTDM), integrated multiplexing techniques based on block-level processing are described together with their design architecture. These multiplexing techniques allow the handling of both bursty traffic and continuous time-multiplexed signals through the same physical multiplexer, while maintaining a design complexity that is not greater than that of a conventional time division multiplexer. By incorporating these multiplexing techniques into the existing network, DTDM will provide a practical migration strategy from the existing predominantly circuit-switched network to a future broadband packet-switched network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel Identification Method of Stator Single Phase-to-Ground Fault for Cable-Wound Generators (2008)

A new criterion to detect the stator single phase-to-ground fault for Powerformer is proposed in this paper, which is based on the direction of zero-sequence compositive power flow. By virtue of the analysis of new fault characteristics of Powerformer and the comparison with conventional methods, a novel identification scheme is put forward. The proposed approach detects the ground fault by analyzing the power direction. Only zero-sequence current from the terminal of Powerformer and zero-sequence voltage from the busbar are used in this scheme. Combined with third-harmonic principle, it can provide a 100% coverage of fault detection for the stator windings of Powerformer. The effectiveness of this scheme is validated with the Matlab simulation results.
Virus and protein crystal growth on earth and in microgravity (1993)

Protein and virus crystals commonly grown in the laboratory on earth have also been grown in a microgravity environment on the US Space Shuttle. Two techniques for growth of the crystals were investigated: vapour diffusion and direct liquid-liquid diffusion. Crystals produced in microgravity, although generally isomorphous with earth-grown crystals, frequently show positive changes in habit, size and degree of perfection. X-ray diffusion analyses of crystals grown free from gravity usually show an improvement in the intensity-to-background ratio for all resolution ranges, and in some cases an extension of the resolution of the diffraction patterns to a higher limit. Both findings suggest an overall improvement in the quality of macromolecular crystals grown in space. A possible source of this improvement is the formation of depletion zones around crystals growing in microgravity that remain stable in the absence of convection and thereby allow more self-regulated growth. This in turn may be manifested as a more uniform and general ordering of the molecules in the crystal lattice and/or a reduction in gross crystal imperfections. Some illustrative results obtained in two kinds of macromolecular crystal growth experiments on International Microgravity Laboratory-1 are described.
Variable Pitch Propeller for UAV-Experimental Tests (2020)

Growth in application fields of unmanned aerial vehicles (UAVs) and an increase in their total number are followed by higher and higher expectations imposed on improvements in UAV propulsion and energy management systems. Most commercial vertical takeoff and landing (VTOL) UAVs employ a constant pitch propeller that forces a mission execution tradeoff in the majority of cases. An alternative solution, presented here, consists of the use of a variable pitch propeller. The paper summarizes experimental measurements of the propulsion system equipped with an innovative variable pitch rotor. The investigations incorporated characteristics of the rotor for no wind conditions and a new approach to optimize pitch settings in hover flight as a function of UAV weight and energy consumption. As UAV battery capacity is always limited, efficient energy management is the only way to increase UAV mission performance. The study shows that use of a variable pitch propeller can increase the maximal takeoff weight of the aircraft and improve power efficiency in hover, especially if load varies for different missions. The maximal thrust measured was 31% higher with respect to the original blade settings. The coefficient of thrust during hover showed an increase of 2.6% up to 7.5% for various pitch angles with respect to the original fixed propeller.
Plättchenfunktion und hochdosierte Methotrexat-Behandlung mit Citrovorumfaktor-Rescue (1984)

Unter hochdosierter Methotrexat (HDMTX)-Behandlung mit citrovorum factor rescue (CFR) wurden Blutungen infolge Thrombozytopenie und/oder plasmatischer Gerinnungsstörungen beschrieben. Die Plättchenfunktion selbst wurde bisher noch nicht untersucht. In-vitro-Untersuchungen ergaben eine konzentrationsabhängige Hemmung der Thrombozytenaggregation durch MTX. Auch die spontane Plättchenfaktor-3 (PF 3)-Verfügbarkeit wird in vitro durch MTX vermindert. Ex-vivo-Untersuchungen bei 10 Patienten mit HDMTX-Therapie (6 bzw. 12g/m2) und CFR bestätigen die verminderte PF-3-Verfügbarkeit, während die Aggregationstests normal ausfallen. Eine schwere Störung der Plättchenfunktion unter HDMTX- + CFR-Behandlung konnte nicht nachgewiesen werden. Trotzdem ist bei einer ungeklärten Blutungsneigung unter der HDMTX-+ CFR-Behandlung im Einzelfall an eine Störung der Plättchenfunktion durch Methotrexat zu denken.
Evaluation of the safety and efficacy of a novel product for the removal of impacted human cerumen (2017)

This trial is registered on http://www.clinicaltrials.gov/. The registration number is NCT02829294. The trial was retrospectively registered on July 8, 2016.
The importance of diabetic nephropathy in current nephrological practice (2003)

Although the awareness of the importance of normalizing blood pressure levels and tight glycaemic control have allowed improved survival of diabetic patients, the mortality excess remains unacceptably high in patients with diabetic nephropathy. New treatment strategies are under investigation, including inhibitors of AGE formation, protein kinase C inhibitors, antioxidants, glycosaminoglycans, PPAR-gamma agonists and COX-2 inhibitors.
ARCBALL: A user interface for specifying three-dimensional orientation using a mouse (1992)

Arcball is an input technique for 3-D computer graphics, using a mouse to adjust the spatial orientation of an object. In Arcball, human factors and mathematical fundamentals come together exceptionally well. Arcball provides con-sistency between free and constrained rotations using any direction as an axis; consistent visual input and feedback; kinesthetic agreement between mouse motion and object rotation; and consistent interpretation of mouse position. Attention to mathematical detail facilitates the tasks of users and implementors. Users say that as a general-purpose rotation controller Arcball is easier to use than its nearest rival, the Virtual Sphere. It is also more powerful, and simpler to implement. Résumé Arcball est une interface utilisateur pour un système de visualisation 3D utilisant la souris pour orienter les objets dans l’espace. Dans Arcball, facteurs humains et concepts mathématiques se marient exceptionnellement bien. Arcball assure la consistence entre rotations libres et contraintes quelle que soit la direction de leur axe. Consistence entre l&apos;entrée et la réponse; accord kinésique entre mouvements de la souris et rotations de l’objet; interprétation consistente des positions de la souris. Les utilisateurs affirment que le contrôleur universel de rotation Arcball est plus simple à utiliser que son concurent direct: «the Virtual Sphere». Il est aussi plus puissant et plus simple à implémenter. Key Words: object movement, view movement, mouse, user interface, interactive graphics, 3D graphics, rotation,
Chronic PYY<sub>3–36</sub> treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice (2006)

PYY(3-36) is a gut-derived hormone acting on hypothalamic nuclei to inhibit food intake. We recently showed that PYY(3-36) acutely reinforces insulin action on glucose disposal in mice. We aimed to evaluate effects of PYY(3-36) on energy metabolism and the impact of chronic PYY(3-36) treatment on insulin sensitivity. Mice received a single injection of PYY(3-36) or were injected once daily for 7 days, and energy metabolism was subsequently measured in a metabolic cage. Furthermore, the effects of chronic PYY(3-36) administration (continuous and intermittent) on glucose turnover were determined during a hyperinsulinemic-euglycemic clamp. PYY(3-36) inhibited cumulative food intake for 30 min of refeeding after an overnight fast (0.29 +/- 0.04 vs. 0.56 +/- 0.12 g, P = 0.036) in an acute setting, but not after 7 days of daily dosing. Body weight, total energy expenditure, and physical activity were not affected by PYY(3-36). However, it significantly decreased the respiratory quotient. Both continuous and intermittent PYY(3-36) treatment significantly enhanced insulin-mediated whole body glucose disposal compared with vehicle treatment (81.2 +/- 6.2 vs. 77.1 +/- 5.2 vs. 63.4 +/- 5.5 micromol.min(-1).kg(-1), respectively). In particular, PYY(3-36) treatment increased glucose uptake in adipose tissue, whereas its impact on glucose disposal in muscle did not attain statistical significance. PYY(3-36) treatment shifts the balance of fuel use in favor of fatty acids and enhances insulin sensitivity in mice, where it particularly promotes insulin-mediated glucose disposal. Notably, these metabolic effects of PYY(3-36) remain unabated after chronic administration, in contrast to its anorexic effects.
Decellularized Tracheal Matrix Scaffold for Tissue Engineering (2012)

At the point of complete antigen removal, detergent-enzymatic treatment altered tracheal extracellular matrix composition but preserved the major structure and adequate mechanical strength. The matrix provided a compatible and supportive environment for recellularization.
Development of Eggs, Larvae and Juveniles of Bluegill, Lepomis macrochirus RAFINESQUE (1987)

Bluegill, Lepomis macrochirus RAFINESQUE, has bred widely in the various districts of Korea since the Office of Fishery transplanted it into our country from Japan in December, 1969. On August 17, 24 in 1985, bluegill were caught in the reservoir of Habuk-Myon, Yangsan-Gun, , Korea. They spawned in the rearing aquarium on July 13 and August 2 in 1986. The eggs of this species are adhesive and demersal. The size of the egg diameters were varied from 1.18 to 1.30 mm. Hatching took place in 40 hours after fertilization at the water temperature of . The newly botched larvae were 3.75-4.05 mm in total length possessing yolk sac, and 29-30 mytomes. Many melanophores were evenly distributed on the entire body. Ten days after hatching, the postlarvae attained 6.05-6.35 mm in total length. The yolk sac was completely absorbed and the width of the pectoral finfold had reached the maximum size. One month fifteen days after hatching, the juvenile attained 25.20 mm in total length.
Generalized Fast Algorithms for the Polynomial Time-Frequency Transform (2007)

This paper presents a general class of fast algorithms for computing the polynomial time-frequency transform (PTFT) of length-a <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</sup> b, where a, b, and p are positive integers. The process of derivation shows some interesting properties that are effectively used for minimization of the computational complexity. By assigning values of a, b, and p, various algorithms, for example, radix-o and split-radix-2/(2a), can be easily obtained to provide the flexibility supporting polynomial time-frequency transforms of various sequence lengths. The detailed analysis on the computational complexities needed by these algorithms is also presented in terms of the numbers of additions and multiplications. It is shown that the proposed algorithms significantly reduce the computational complexity for applications that deal with polynomial phase signals.
Research on driver experience based route planning method (2010)

Conventional navigation systems usually calculate routes based on costs of each road link, which may be length, speed limit, width, real-time traffic condition, etc. Therefore the routes planned by current navigation system may be shortest distance route, shortest time route, expressway used route, etc. However, due to inaccurate or delayed information, the calculated routes are not always satisfying. To solve the problem, our route planning method considers drivers' experience, i.e. frequent routes. Frequent routes are the routes along which drivers usually drive between a pair of origin and destination. The route planning results based on frequent routes can fit to drivers' preferences more precisely than conventional results.
Rapid Antibiotic Susceptibility Testing in a Microfluidic pH Sensor (2013)

For appropriate selection of antibiotics in the treatment of pathogen infection, rapid antibiotic susceptibility testing (AST) is urgently needed in clinical practice. This study reports the utilization of a microfluidic pH sensor for monitoring bacterial growth rate in culture media spiked with different kinds of antibiotics. The microfluidic pH sensor was fabricated by integration of pH-sensitive chitosan hydrogel with poly(dimethylsiloxane) (PDMS) microfluidic channels. For facilitating the reflectometric interference spectroscopic measurements, the chitosan hydrogel was coated on an electrochemically etched porous silicon chip, which was used as the substrate of the microfluidic channel. Real-time observation of the pH change in the microchannel can be realized by Fourier transform reflectometric interference spectroscopy (FT-RIFS), in which the effective optical thickness (EOT) was selected as the optical signal for indicating the reversible swelling process of chitosan hydrogel stimulated by pH change. With this microfluidic pH sensor, we demonstrate that confinement of bacterial cells in a nanoliter size channel allows rapid accumulation of metabolic products and eliminates the need for long-time preincubation, thus reducing the whole detection time. On the basis of this technology, the whole bacterial growth curve can be obtained in less than 2 h, and consequently rapid AST can be realized. Compared with conventional methods, the AST data acquired from the bacterial growth curve can provide more detailed information for studying the antimicrobial behavior of antibiotics during different stages. Furthermore, the new technology also provides a convenient method for rapid minimal inhibition concentration (MIC) determination of individual antibiotics or the combinations of antibiotics against human pathogens that will find application in clinical and point-of-care medicine.
Pretreatment of different biological matrices for exogenous testosterone analysis: a review (2017)

The presence of exogenous testosterone has been monitored mainly in the urine and blood. However, other biological matrices such as hair, nail, and saliva samples can be used successfully for in vivo measurement. Chromatographic analysis requires pretreatment to obtain free testosterone and its metabolites. Among the pretreatment procedures, digestion, hydrolysis and solvolysis steps are conducted to reach the analytical purpose. Digestion assay is indicated for hair and nail samples. First, it is recommended to perform the decontamination step. After that, alkaline solution (NaOH), organic solvents and other reagents can be added to the samples and incubated under determined conditions for the digestion step. Hydrolysis assay is recommended to urine and blood samples. Acid hydrolysis cleaves conjugated testosterone and its metabolites using HCl or H<sub>2</sub>SO<sub>4</sub> solution at appropriate time and temperature. However, there is formation of interferent compounds, degradation of dehydroepiandrosterone and decrease of peak resolution for epitestosterone. Enzymatic hydrolysis is an alternative technique able to promote free testosterone and its metabolites with low degradation. It is important to establish the best conditions according to the biological fluid and the amount of the sample. Sulfatase enzyme is recommended together with β-glucuronidase to cleave sulfoconjugate steroids. Solvolysis assay is similar to acid hydrolysis, but organic solvents are responsible to promote steroid deconjugation. Other approaches such as combination of different pretreatments, surface response or ultrasonic energy have been used to obtain the total of free steroids. So, the biological matrix defines the best procedure for pretreatment to achieve the analytical purpose, knowing its advantages and limitations.