gebhart/patrepeval huggingface dataset:
Serum Bone Gla Protein and the Vitamin D Endocrine System in the Oophorectomized Rat (1988)

Because of the importance of estrogen in osteoporosis, the effects of decreased estrogen production using sensitive measurements of bone mineral metabolism were studied in oophorectomized rats. Serum levels of ionized calcium, bone gla protein (BGP), vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin D), and estradiol were measured before and serially for 6 weeks after oophorectomy in the rat. In addition, static and dynamic indices of bone histomorphometry were determined after double tetracycline labeling. Fifty Sprague-Dawley female rats (approximately 250 g) were studied. Twenty-five rats underwent oophorectomy (O), while the remaining rats were sham operated. Estrogen deficiency was noted in the O group within a week after surgery (estradiol, 2.45 +/- 0.78 vs. 27.9 +/- 4.15 pg/ml; P less than 0.05). Serum ionized calcium levels, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and PTH levels did not differ between the two groups during the length of the study. Serum BGP levels were the same in both groups until the second week postoophorectomy, after which BGP remained significantly elevated in the O animals (121.7 +/- 5.95 vs. 76.7 +/- 3.87; P less than 0.001). Bone histomorphometry revealed increased osteoid volume (4.4 +/- 0.9% vs. 2.3 +/- 0.7%), osteoblast surface (26.5 +/- 2.4% vs. 3.2 +/- 1.2%), tetracycline surface (18.9 +/- 4.1% vs. 6.8 +/- 2.2%), as well as osteoclast surface (8.2 +/- 1.4% vs. 2.5 +/- 2%) in all O animals compared with those in the sham-operated group. These data indicate that oophorectomy and decreased estrogen result in increased bone turnover with elevated BGP levels. The marked BGP elevation within 2 weeks postoophorectomy suggests that estrogen withdrawal results in rapid altered bone mineral metabolism. The lack of concomitant increase in circulating PTH levels suggests that other factors may be mediating the bone loss following surgical oophorectomy.
Art History in the Mirror Stage: Interpreting un Bar aux Folies Bergeres (1990)

Much can be learnt about the procedures of art historians by a close analysis of one example. My chosen example is T. J. Clark's account of Manet's Un Bar aux Folies Bergeres. Focusing on his analysis, I compare it to interpretations of that picture by Robert Herbert and Richard Wollheim, and to a new account of my own, suggested by Clark's. I am interested in comparing these interpretations of the same artwork because I am concerned with the role played in interpretation by the rhetoric in the texts of art historians, and how those texts may be read both literally and ironically. There are a number of reasons why this example is well worth considering at such length. It raises in a focused way these important general questions about the texts of art historians. Among art historians, Clark has played a significant role in promoting concern with the social history of art. Much traditional art history treated paintings in formalist ways, isolating them from the context in which they were produced, purchased, and displayed. Clark's highly controversial work has recently been one important model for post-formalist art historians. Already his pupils and followers constitute an identifiable group of productive scholars. An older Marxist tradition urged that analysis of the class structure of the society in which paintings were produced could help explain the content and composition of artworks. Clark's different approach involves placing the artwork in the context of critical commentary by contemporaries of the artist. Such commentary displays the values of a culture; reading it to learn what critics see, and fail to see, in a painting is immensely instructive. Learning how the contemporaries of Courbet and Manet responded to their paintings teaches us much about both their individual paintings and the nineteenth-century French culture
A branching-process solution of the polydisperse coagulation equation (1984)

The polydisperse coagulation equation models irreversible aggregation of particles with varying masses. This paper uses a one-parameter family of discrete-time continuous multitype branching processes to solve the polydisperse coagulation equation when The critical time t c when diverges corresponds to a critical branching process, while post-critical times t &gt; t c correspond to supercritical branching processes.
Optimizing Open vSwitch to Support Millions of Flows (2017)

Software switch has emerged as a critical component in software defined networking and network virtualization areas. Open vSwitch (OvS) is a widely used software switch which uses tuple space search algorithm for packet classification, and an exact match cache (EMC) for caching most frequently used flows. In this paper, we propose two new optimizations for OvS to further improve its performance and scalability. First aims to completely remove the sequential search overhead of the tuple space search layer of OvS, and second is a dynamic cache insertion optimization for the EMC to improve EMC effectiveness. We show that the optimizations can improve OvS's throughput by up to 3.5X for millions of active flows.
Acousto-optically tunable lithium niobate photonic crystal (2010)

We report on an active two-dimensional lithium niobate photonic crystal (PhC) driven by stationary Rayleigh surface acoustic waves. The configuration relies on two interdigital transducers that modulate the refractive index through the acousto-optical effect. Highly efficient, compact acousto-optical PhCs with an active length of only 13 μm and a driving electrical power of 20 mW have been fabricated and characterized. Experiments show that an enhancement factor of the elasto-optical interaction of the order of 61 is obtained thanks to slow light effects in the PhC.
A Southern Transcontinental Railroad into California: Texas and Pacific versus Southern Pacific, 1865-1885 (1936)

Research Article| March 01 1936 A Southern Transcontinental Railroad into California: Texas and Pacific versus Southern Pacific, 1865-1885 Lewis B. Lesley Lewis B. Lesley Search for other works by this author on: This Site PubMed Google Scholar Pacific Historical Review (1936) 5 (1): 52–60. https://doi.org/10.2307/3633318 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Lewis B. Lesley; A Southern Transcontinental Railroad into California: Texas and Pacific versus Southern Pacific, 1865-1885. Pacific Historical Review 1 March 1936; 5 (1): 52–60. doi: https://doi.org/10.2307/3633318 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentPacific Historical Review Search This content is only available via PDF. Copyright 1936 The Arthur H. Clark Company Article PDF first page preview Close Modal You do not currently have access to this content.
Effect of water-table management and nitrogen supply on yield, plant growth and water use of corn in undisturbed soil columns (1996)

The effect of three water-table depths (30, 60 and 80 cm below the soil surface) and four N rates (0, 45, 90 and 135 kg ha −1 ) on plant growth, yield and water use were evaluated for corn (Zea mays L.). Research was conducted in a greenhouse, using 36 undisturbed foil columns (20 cm i.d. and 90 cm length) collected with a Meta-Drill vibrating core sampler from a Fox sandy loam soil at Harrow Research Centre. Corn grown in the 80-cm water-table depth had the greatest degree of water stress, as indicated by low volumetric soil water content, low stomatal conductance and transpiration rates, and elevated soil-surface and leaf-surface temperatures. There was a substantial increase in plant dry weight and grain yields as the N rates increased from 0 to 135 kg ha −1 with the 30- and 60-cm water-table depths. Under our experimental conditions, maximum grain yields were obtained with a 60-cm water-table depth. Grain yields were significantly reduced with the 80-cm water-table depth. With this water-table depth, grain yield was also reduced by N addition. Key words: Water-table management, Zea mays, yield, stomatal conductance, leaf temperature
On the State Space of the Binary Neural Network (1988)

Analysis of the state space for the fully-connected binary neural network ("the Hopfield model") remains an important objective in utilizing the network in pattern recognition and associative information retrieval. Most of the research pertaining to the network's state space so far concentrated on stable-state enumeration and often it was assumed that the patterns which are to be stored are random. We discuss the case of deterministic known codewords whose storage is required, and show that for this important case bounds on the retrieval probabilities and convergence rates can be achieved. The main tool which we employ is Birth-and-Death Markov chains, describing the Hamming distance of the network's state from the stored patterns. The results are applicable to both the asynchronous network and to the Boltzmann machine, and can be utilized to compare codeword sets in terms of efficiency of their retrieval, when the neural network is used as a content addressable memory.
INSTRUCTIONAL DESIGN AND ASSESSMENT Instructional Model to Teach Clinically Relevant Medicinal Chemistry (2006)

The relevance of medicinal chemistry to pharmacy practice has been questioned by many pharmacy educators as more emphasis has been placed on linking clinical knowledge and practice to pharmacy student educational outcomes. Faculty teaching in medicinal chemistry and other biomedical and pharmaceutical science courses have embraced this challenge. Various teaching methods and ap-proaches within medicinal chemistry that emphasize application of this knowledge have been sought to improve the usefulness of this scientific discipline to the future careers of students. The newly revised ACPE guidelines and standards have reemphasized the role of the sciences in the curriculum. With this mandate, it is essential that all science faculty members adjust the way they teach to meet the new desired outcomes for pharmacy graduates. This manuscript describes an instructional model for teaching medicinal chemistry explicitly designed to meet these outcomes. A process of collaboration between experienced pharmacy faculty scholars was used to derive this approach. Pedagogy for cognitive and affective learning was incorporated. A case study using a representative drug class is presented to illustrate this model.
DRYING CERAMICS IN ULTRAHIGH-FREQUENCY ELECTRICAL FIELDS (1961)

Abstract : The program undertaken was designed to determine the applicability of dielectric heating to the drying of ceramic components fabricated by wet processing techniques. The general characteristics of dielectric drying were studied along with the specific moisture removal characteristics for a typical wet-processed ceramic composition (50% clay, 25% flint, 25% feldspar). The results obtained in this investigation showed that rapid drying rates for ceramics are possible with the dielectric heating method. Wet ceramic components can be heated and dried uniformly in the electric field without the development of severe temperature and moisture gradients which might lead to cracking and/or warping of the components. Although drying rates were found to be extremely high, they are limited by the rupture strength of the material, i. e., its ability to withstand the stresses developed by the pressure of the escaping water vapor. Dielectric drying holds interesting possibilities for drying high-cost ceramic components or component systems which are difficult to process by other techniques.
The Absorption of Sound in Mixtures of Gases which Exhibit a Vibrational Relaxation Time (1953)

The absorption of sound has been measured in CO2 and CS2 and also in mixtures of these gases. The apparatus consists of a glass tube approximately 0.84 cm in radius and 60 cm long, a movable ribbon speaker, and a fixed condenser microphone. The resulting sound pressure-distance curves were recorded and yield the sound absorption coefficient. The coefficient was then corrected for the tube effect and multiplied by the sound wavelength, giving the absorption coefficient per wavelength (μ). The range of frequencies and pressures used were 2 to 9 kc and 3 to 250 mm of Hg, respectively. Curves of μ vs ratio of frequency over pressure yield μmax = 0.260, frequency of maximum absorption (νmax) = 32 kc for CO2, and μmax = 0.389, νmax = 408 kc for CS2. As pure CO2 was diluted with CS2 the resulting curves gradually increased in height and infrequency of maximum absorption approaching the μmax and νmax of pure CS2. This project was supported by the ONR.
Binding of tolmetin and salicylic acid to human serum albumin as a function of temperature (1981)

When drug-protein binding data are evaluated thermodynamically standard free energy (delta G0), standard enthalpy (delta H0) and standard entropy (delta S0) are usually estimated from association constants (Ka) derived from binding data obtained at only two temperatures. Estimation of delta H0 involves the assumption of its constancy in the temperature range studied and linearity of a van't Hoff plot of ln Ka versus 1/T. Sometimes the assumption of such linearity is invalid for theoretical reasons and data obtained at only two temperatures contain no information concerning linearity of this plot. We present data for the binding of both tolmetin and salicylic acid to human serum albumin as a function of temperature which make doubtful the validity of using association constants of these drugs to derive thermodynamic constants other than delta G0 values.
Multiple proteases in foot-and-mouth disease virus replication (1984)

Translation of foot-and-mouth disease virus RNA in a rabbit reticulocyte lysate for short time intervals resulted in the production of the peptides P20a , P16, and P88 (Lab, Lb, and P1) (R. R. Rueckert , Recommendations of the 3rd European Study Group on Molecular Biology of Picornavirus, Urbino , Italy, 1983). If further translation was prevented, the structural protein precursor P88 was not cleaved, even after prolonged incubation. This result indicates that the mechanism of the cleavage between P20a -P16 and P88 and of that between P88 and P52 (P2) differs from the mechanism of the secondary cleavages which produce the structural proteins. Furthermore, treatment of foot-and-mouth disease virus-infected cells with the protease inhibitor D-valyl phenylalanyl lysyl chloromethyl ketone prevented the in vivo cleavage between P20a -P16 and P88 but had no effect on any of the other cleavage events. These results suggest that the cleavage of the foot-and-mouth disease virus polyprotein utilizes two different host proteases.
Avoid MIC-related problems in nuclear cooling systems (1990)

Microbial films develop on virtually any type of metal, including stainless steel, that is exposed to natural water. While the resultant phenomenon, microbiologically-influenced corrosion (MIC), can affect electric generating plants of all types, it is a particular risk at nuclear power plants. This special susceptibility to MIC arises from the long construction times, extended outages and redundant designs that are involved, which all result in low-flow or stagnant conditions. An overview of the mechanism of MIC is given and the steps available to avoid its occurrence or mitigate its effects are described.
Regulation of Fibroblast Motility by the Protein Tyrosine Phosphatase PTP-PEST (1999)

The protein tyrosine phosphatase PTP-PEST is a cytosolic enzyme that displays a remarkable degree of selectivity for tyrosine-phosphorylated p130(Cas) as a substrate, both in vitro and in intact cells. We have investigated the physiological role of PTP-PEST using Rat1 fibroblast-derived stable cell lines that we have engineered to overexpress PTP-PEST. These cell lines exhibit normal levels of tyrosine phosphorylation of the majority of proteins but have significantly lower levels of tyrosine phosphorylation of p130(Cas) than control cells. Initial cellular events occurring following integrin-mediated attachment to fibronectin (cell attachment and spreading) are essentially unchanged in cells overexpressing PTP-PEST; similarly, the extent and time course of mitogen-activated protein kinase activation in response to integrin engagement is unchanged. In contrast, the reduced phosphorylation state of p130(Cas) is associated with a considerably reduced rate of cell migration and a failure of cells overexpressing PTP-PEST to accomplish the normally observed redistribution of p130(Cas) to the leading edge of migrating cells. Furthermore, cells overexpressing PTP-PEST demonstrate significantly reduced levels of association of p130(Cas) with the Crk adaptor protein. Our results suggest that one physiological role of PTP-PEST is to dephosphorylate p130(Cas), thereby controlling tyrosine phosphorylation-dependent signaling events downstream of p130(Cas) and regulating cell migration.
Network Coded Modulation with partial side-information and hierarchical decode and forward relay sharing in multi-source wireless network (2010)

We present a strategy for the relay sharing in the 2-source relay wireless network with the hierarchical decode and forward relaying. It processes both incoming coded symbols through the minimal hierarchical symbol mapping of the same cardinality as the two individual symbol streams and requires a full (perfect) Complementary Side-Information (C-SI) on the other stream available at the destination. This scheme is known to have an advantage in a rectangular shape capacity region which provides higher sum-capacity than the classical MAC. We investigate the capacity region of the case where the destination has only partial C-SI available through a wireless link. We conclude that the overall finite alphabet constrained capacity region including both MAC and BC phase remains rectangular. The BC phase region is limited by the C-SI link capacity and we conjecture that it obeys (in some cases with some small margin) the capacity product law of the individual relay to destination and C-SI links.
Design and Implementation Issues for Modern Remote Laboratories (2010)

The design and implementation of remote laboratories present different levels of complexity according to the nature of the equipments operated by the remote laboratory, the requirements imposed on the accessing computers, the network linking the user to the laboratory, and the type of experiments the laboratory supports. This paper addresses the design and implementation of remote laboratories employing web technologies, both at the client and the server side. These types of remote laboratories are called WebLabs, and can be deployed over different networks such as the public internet, campuswide networks, or high-speed private networks. Although most published works on WebLabs focus on their functional and operational aspects, nonfunctional requirements related to security, quality of service, and federated operation of WebLabs have received little attention. This paper addresses how these requirements can be incorporated into WebLab design, and discusses the most appropriate web technologies to fulfill such requirements.
Efectos de los teléfonos móviles en la salud: Nuevas evidencias (2001)

Si bien la primera demanda contra las companias de telefonia movil en la que se las acusaba de originar un cancer cerebral debido a los efectos de la RF en la cabeza fue desestimada por falta de evidencia, lo cierto es que supuso un acicate para la busqueda de evidencias. El esfuerzo investigador ofrece nueve anos despues unos primeros frutos que plantean problemas de ingenieria de dificil solucion.
Phase and thickness dependent modulus of Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub> films down to 25 nm thickness (2012)

The mechanical properties of phase-change materials including Ge2Sb2Te5 (GST) are strongly influenced by the complex interaction of phase and imperfection distributions, especially at film thicknesses relevant for phase-change memory devices. This work uses a micromechanical resonator as a substrate to study the phase dependent modulus of GST films with thicknesses from 25 nm to 350 nm. The moduli of amorphous GST and crystalline GST films increase with decreasing thickness to 10 GPa and up to 60 GPa, respectively. The phase purity is studied using X-ray diffraction and energy dissipation data, which provide qualitative information about inelastic absorption.
Stability of nonlinear Hawkes processes (1996)

We address the problem of the convergence to equilibrium of a general class of point processes, containing, in particular, the nonlinear mutually exciting point processes, an extension of the linear Hawkes processes, and give general conditions guaranteeing the existence of a stationary version and the convergence to equilibrium of a nonstationary version, both in distribution and in variation. We also give a new proof of a result of Kerstan concerning point processes with bounded intensity and general nonlinear dynamics satisfying a Lipschitz condition.
Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular Degeneration (2024)

This animal study may provide new insights into the relationship between early AMD-associated metabolic changes and FLIO findings.
Clinical prognostic indicators of surgical outcome in cervical spondylotic myelopathy (2009)

Age, duration of symptoms, and preoperative neurological function should be discussed with patients when surgical intervention for cervical spondylotic myelopathy is considered. Preoperative sensory-evoked potentials may be considered for patients in whom clinical factors do not provide clear guidance if such information would potentially change therapeutic decisions.
Biochemical characterization of desmosomal proteins isolated from bovine muzzle epidermis: amino acid and carbohydrate composition. (1985)

The seven major desmosomal polypeptides from isolated bovine muzzle desmosomes ranging from Mr 75 000 to 250 000 were separated by gel electrophoresis, isolated and characterized with respect to their amino acid composition and sugar content. The two largest polypeptides (bands 1 and 2), i.e. desmoplakins I and II, are similar in their amino acid composition, confirming our previous immunological and biochemical data, and display a relatively high glycine content. In contrast, the other two cytoplasmic components also believed to be associated with the desmosomal plaque, i.e. polypeptides of bands 5 (Mr 83 000) and 6 (Mr 75 000), differ significantly in their amino acid composition from the desmoplakins and from each other. All four candidate polypeptides for plaque association, i.e. bands 1, 2, 5, and 6, show no significant glycosylation. The glycoproteins 4a and 4b (Mr 115 000 and 130 000) are similar in their amino acid composition, peptide analysis and immunological reactivity. Both are relatively rich in mannose and galactose but also contain sialic acid. Our determinations also indicate that the two polypeptides differ significantly in their N-acetylglucosamine and mannose content. Most, if not all, of the sugar residues are associated with a water-soluble fragment of Mr 15 500 obtained after limited digestion with V8 protease. The glycopolypeptides obtained in band 3 (Mr 164 000-175 000) are distinct from the glycopolypeptides 4a and 4b in amino acid composition, sugar content, isoelectric pH values, certain antigenic determinants and in their pattern of cleavage products obtained by treatment with proteases or cyanogen bromide. The results identify polypeptides of bands 3, 4a and 4b as glycosylated with characteristic sugar compositions. It is suggested that the major glycoproteins (bands 3, 4a, 4b) of the desmosome are integral membrane components arranged in a special way conferring resistance to detergent treatment. The possible roles of these glycoproteins in cell recognition and in adhesive functions of the desmosome are discussed.