gebhart/patrepeval huggingface dataset:
Microcirculatory Measurements of Normal Maxillo-facial (1992)

The Laser Doppler velocimeter has beeen developed to evaluate the microcirculatory blood flow in human tissues. We have been used this instrument and reported the blood circulation of D-P flap and Abbe flap.In this paper, normal tissue blood circulation was measured in maxillo-facial region by Laser Doppler Velocimeter.The data of the microcirculatory blood flow was analyzed by using personal use computer.The software for data analyzing was developed by ourselves. The following results were obtained.1) Normal microcirculatory blood flow at the intraoral mucosa and the facial skin were measured by Laser Doppler Veclocimeter.2) Blood circulation values of the intraoral mucosa were larger than them of the facial skin.3) Blood circulation values were larger in male than in female at the several points of maxillofacial region.
Viscosity of clay suspensions in the presence of polyanionic flocculants (1956)

No disponible
Cu(I)/Pd(0)-Catalyzed Cross-Coupling Reaction of Alkynylsilanes with Aryl or Alkenyl Triflates: “Sila”-Sonogashira-Hagihara Coupling (1997)

Abstract Alkynylsilanes reacted with aryl or alkenyl triflates in the presence of 5 mol% of Pd(PPh3)4 and 10 mol% of CuCl in DMF to give the corresponding cross-coupling, namely “sila”-Sonogashira-Hagihara coupling, products in good to excellent yields. The present reaction is highly effective for one-pot synthesis of unsymmetrical diarylacetylenes.
Diffusion of Circular DNA in Two‐Dimensional Cavity Arrays (2009)

Through a two-dimensional cavity array with connecting pores of submolecular size, diffusion of relaxed circular and linear DNA molecules is visualized by fluorescence microscopy. Across the entropic barriers transport regime, associated with spatially heterogeneous confinement of flexible polymers, circular DNA diffuses slower than linear DNA of the same length, a trend indicating that linear DNA preferably moves through connecting pores by the threading of an end rather than the looping of a midsection.
A practical approach to high assurance multilevel secure computing service (2002)

Current projects aimed at providing MLS computing services rarely seem to exploit advances in related fields. Specifically, the concepts of data distribution, replication, and interoperation are currently receiving much attention in the commercial database system sector but have yet to be applied to the delivery of MLS computing services. This paper explains how these concepts might kelp deliver MLS computing services relatively, quickly and cheaply, and how they can ease integration of legacy systems and new technology into future MLS cooperative, distributed computing environments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Kinetics of Catalytic Dehydrogenation of Ethylbenzene to Styrene (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of Catalytic Dehydrogenation of Ethylbenzene to StyreneSergio Carrà and Lucio ForniCite this: Ind. Eng. Chem. Process Des. Dev. 1965, 4, 3, 281–285Publication Date (Print):July 1, 1965Publication History Published online1 May 2002Published inissue 1 July 1965https://pubs.acs.org/doi/10.1021/i260015a009https://doi.org/10.1021/i260015a009research-articleACS PublicationsRequest reuse permissionsArticle Views3023Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
GNbAC1, a Humanized Monoclonal Antibody Against The Multiple Sclerosis Associated Retrovirus Envelope Protein, Is Well Tolerated In Patients With Multiple Sclerosis. (P2.217) (2014)

OBJECTIVES: To assess the safety, pharmacokinetics and pharmacodynamics over 1 year of GNbAC1, a monoclonal antibody agonist of the Multiple Sclerosis associated Retrovirus (MSRV) Env protein in multiple sclerosis (MS) patients. BACKGROUND: Human endogenous retrovirus (HERV) genes represent 8% of the human genome. Among HERV genes, the Multiple Sclerosis associated Retrovirus (MSRV) DNA contains copies expressing a protein called Env, which can activate a pro-inflammatory and autoimmune cascade via Toll-Like receptor 4. MSRV-Env expressed in multiple sclerosis (MS) plaques has an inhibitory effect on oligodendrocyte precursor cell differentiation and affects remyelination. GNbAC1, a humanised monoclonal antibody, binds MSRV-Env. Blocking MSRV-Env by GNbAC1 is expected to have a neuroprotective effect in MS. DESIGN: We report the results of Phase II single ascending dose study followed by a 12-month open-label extension to evaluate the safety, pharmacokinetics and pharmacodynamics of GNbAC1 in 10 MS patients. First, in Cohort 1, 5 patients were randomized to receive a single intravenous infusion of 2 mg/kg of GNbAC1 or placebo; in Cohort 2, 5 patients were randomized to receive an intravenous infusion of 6 mg/kg of GNbAC1 or placebo. Then, all patients of Cohorts 1 and 2 pursued treatment with 11 GNbAC1 infusions at 2 mg/kg and 6 mg/kg dose respectively at 4-week intervals. RESULTS: Over the long term, GNbAC1 was well tolerated at both doses. No safety or immunogenicity signals were detected. Pharmacokinetic data confirm a dose linear pharmacokinetics with an elimination half-life of 15-17 days compatible with monthly infusions. Pharmacodynamic and MSRV biomarkers are presented. CONCLUSIONS: The 12-month results confirm the favorable long-term GNbAC1 safety profile in MS patients and the pharmacokinetics allows monthly administration scheme. These results support the launch of a larger Phase II study testing the efficacy and safety of the first monoclonal antibody targeting the MSRV-Env protein.
Hole geometry and anisotropic effects on tube-wave propagation; a quasi-static study (1990)

Abstract Tube-wave characteristics, namely velocity and polarization, are affected by borehole anomalies related to nonhydrostatic tectonic stress. The anomalies we consider are borehole ellipticity, azimuthal anisotropy as modeled by a rotated transversely isotropic medium, and borehole breakouts as modeled by local heterogeneities in elastic properties. The low-frequency tube-wave velocity is obtained by a variational approach to a plane-strain, static-equilbrium problem. We solve the problem with hole ellipticity analytically and the problem with azimuthal an-isotropy numerically by a finite-element method. The results show that weak ellipticity has a negligible effect on the tube-wave velocity: a relative variation of 10 percent in the main diameters of the hole produces a perturbation of only 0.5 percent in the velocity. However, localized damage to the hole can reduce tube-wave velocity significantly. Furthermore, for tube-wave polarization, it is unrealistic to obtain deviations from the radial direction greater than 15 degrees, which makes it difficult to obtain any valuable information on the stress directions from the tube wave.
Community Detection in Multi-Layer Networks (2012)

Recent years have seen a surge of interest in community detection and a large range of algorithms have been designed and applied to this specific task. However, the vast majority of the work done in the area has been concerned with simple weighted graphs. This results in some of the real world systems being oversimplified to fit this model. In this project, I design a new community detection algorithm capable of detecting communities in multi-layer networks. Multi-layer networks are constituted of a finite set of graphs, called layers, which share the same nodes but differ in their edges. I construct a modeling approach whereby I try to approximate the network using communities. The results show that this approach can reveal multi-layer communities that would not be found using standard community detection tools.
Contingent planning with goal preferences (2006)

The importance of the problems of contingent planning with actions that have non-deterministic effects and of planning with goal preferences has been widely recognized, and several works address these two problems separately. However, combining conditional planning with goal preferences adds some new difficulties to the problem. Indeed, even the notion of optimal plan is far from trivial, since plans in nondeterministic domains can result in several different behaviors satisfying conditions with different preferences. Planning for optimal conditional plans must therefore take into account the different behaviors, and conditionally search for the highest preference that can be achieved. In this paper, we address this problem. We formalize the notion of optimal conditional plan, and we describe a correct and complete planning algorithm that is guaranteed to find optimal solutions. We implement the algorithm using BDD-based techniques, and show the practical potentialities of our approach through a preliminary experimental evaluation.
Ion beam mixing of aluminum and titanium (1989)

The ion beam mixing of Al and Ti by 600 keV Xe ions was studied at room temperature and near 80 K. In view of recent observations of large differences between bilayer and multilayer mixing rates in the Fe-Ti, Ni-Ti, and Cu-Ti systems, both bilayer and buried-layer samples were investigated. Results obtained with the various sample configurations were in good mutual agreement. Comparison to literature data on marker experiments in Al suggested no significant dependence on layer thickness above ∼5 Å. At room temperature, the mixing rate is in excellent agreement with previous multilayer mixing experiments. The initial mixing rate was found to vary by less than 20% between 80 and 300 K. The results are discussed in terms of theoretical models for the mixing mechanisms together with published data on comparable systems. In spite of the low Z values involved, the mixing rate is in good agreement with an expression based on a thermal spike mechanism. At large fluences, a 1260-Å-thick surface layer of Al would suddenly start to degrade quite rapidly.
A PARTIAL HYBRID DEGENERATED PLATE/SHELL ELEMENT FOR THE ANALYSIS OF LAMINATED COMPOSITES (1996)

A degenerated plate/shell element based on the combined energy variational principle and the equivalent single-layer model is proposed. It is derived from the 3-D continuum equation by imposing one constraint on the 3-D isoparametric solid element: a straight line normal to the mid-surface before deformation remains straight but not normal after deformation. The continuities of interlaminar stresses are satisfied at the interlaminar surface and the number of degrees of freedom per node is independent of the number of layers. In this work, the combined energy variational principle is used to overcome transverse stress continuity limitations of single-layer models. The traction-free conditions are satisfied on the upper and lower surfaces of a laminate by assuming the transverse stress components independently. The transverse normal strain is taken into account in order to consider the full 3-D effect in a laminated composite. The iso-function method and the classification method of the stress modes are used to construct the assumed stress field which contains a minimum number of stress modes and guarantees no zero energy mode in the element stiffness matrix. Three examples are presented to illustrate the efficiency and accuracy of the element.
Synthesis of Lignan Natural Products (±)Dehydroxycubebin and (±)Burseran by Intermolecular Nitrile Oxide Cycloaddition<sup>1</sup> (1992)

The synthesis of lignan natural products dehydroxycubebin 1a and burseran 1b by a nitrile oxide cycloaddition of 3,4-methylenedioxybenzonitrile oxide, generated in situ, to 2,5-dihydrofuran followed by reductive cleavage, tosylation and nucleophilic displacement of a secondary tosylate is described.
Fast performance analysis of bus-based system-on-chip communication architectures (2003)

This paper addresses the problem of efficient and accurate performance analysis to drive the exploration and design of bus-based system-on-chip (SOC) communication architectures. Our technique fills a gap in existing techniques for system-level performance analysis, which are either too slow to use in an iterative communication architecture design framework (e.g., simulation of the complete system), or are not accurate enough to drive the design of the communication architecture (e.g., techniques that perform a static analysis of the system performance). The proposed system-level performance analysis technique consists of: initial co-simulation performed after HW/SW partitioning and mapping, with the communication between components modeled in an abstract manner (e.g., as events or data transfers); extraction of abstracted symbolic traces, represented as a bus and synchronization event (BSE) graph, that captures the activity of the various system components and their communication over time; and manipulation of the BSE graph using the bus parameters, to derive the behavior of the system accounting for effects of the bus architecture. We present experimental results on several example systems, including a TCP/IP network interface card sub-system. The results indicate that our performance estimation technique is over two orders of magnitude faster than performing a complete system simulation, while being very accurate (within 2.2% of performance estimates derived from accurate HW/SW co-simulation).
A Tree Matching Approach for the Temporal Registration of Retinal Images (2006)

The temporal registration of retinal images provides an important groundwork for doctors to monitor the progression of diseases. Retinal image registration is challenging because the intensity of the retina and the vascular structure can vary greatly over time. In this paper, we describe a tree matching approach to register retinal images. We model each vessel in a retinal image as a tree, called vessel feature tree (VFT). We design a matching function to compute the similarity of a pair of vessels based on their VFTs. We develop a global alignment algorithm to compute the best match between the vessels in two images. Experiment results on 300 pairs of real-world retina images indicate that the proposed approach is able to achieve an accuracy of 93%
A Sagnac interferometer sensor system for intrusion detection and localization (2004)

A cable, having two optical fibers, is buried in a two foot wide swath surrounding a facility containing buildings and grounds. The fibers are connected to directional couplers to form two fiber Sagnac interferometer loops. By making one loop longer than the other, with an additional fiber spool, not only can an intruder across the perimeter be detected but also the location of the intruder along the perimeter can be ascertained. The proposed system is described and analyzed. Simulation shows that such a system provides an excellent means of perimeter protection at low cost.
Analysis of cell size and DNA content in exponentially growing and stationary-phase batch cultures of Escherichia coli (1995)

Escherichia coli strains were grown in batch cultures in different media, and cell size and DNA content were analyzed by flow cytometry. Steady-state growth required large dilutions and incubation for many generations at low cell concentrations. In rich media, both cell size and DNA content started to decrease at low cell concentrations, long before the cultures left the exponential growth phase. Stationary-phase cultures contained cells with several chromosomes, even after many days, and stationary-phase populations exclusively composed of cells with a single chromosome were never observed, regardless of growth medium. The cells usually contained only one nucleoid, as visualized by phase and fluorescence microscopy. The results have implications for the use of batch cultures to study steady-state and balanced growth and to determine mutation and recombination frequencies in stationary phase.
27. Complexes between metal salts and long-chain aliphatic amines. Part II. The complexes of cuprous halides with long-chain aliphatic amines (1950)

R. G. Wilkins and A. R. Burkin, J. Chem. Soc., 1950, 127 DOI: 10.1039/JR9500000127
ChemInform Abstract: Recent Developments in Enzymic Synthesis of Oligosaccharides and Glycopeptides (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Role of glycosylation in hypoxia-driven cell migration and invasion (2018)

Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit. In hypoxia, HIF-1α stabilizes, forms the heterodimeric complex with HIF-1β, and binds to Hypoxia Response Elements (HRE), activating gene expression to promote metabolic adaptation, cell invasion and metastasis. Furthermore, the focal adhesion kinase, FAK, is activated in hypoxia, promoting cell migration by mechanisms that remain unclear. In this context, integrins, which are glycoproteins required for cell migration, are possibly involved in hypoxia-induced FAK activation. Evidence suggests that cancer cells have an altered glycosylation metabolism, mostly by the expression of glycosyltransferases, however the relevance of glycosylation is poorly explored in the context of hypoxia. Here, we discuss the role of hypoxia in cancer, and its effects on protein glycosylation, with emphasis on integrins and cell migration.
Horizontal principal stress orientation in the Costa Rica Seismogenesis Project (CRISP) transect from borehole breakouts (2015)

Abstract The Costa Rica Seismogenesis Project (CRISP) drilled the Pacific margin of the Middle America Trench just north of where the Cocos Ridge enters the subduction zone, resulting in basal erosion of the upper plate. Here we report the orientations of the maximum horizontal principal stress ( S Hmax ) from borehole breakouts detected by logging‐while‐drilling and wireline downhole measurements. All S Hmax directions were estimated in the sediment cover of the margin, above the deeper rocks of the deformed margin wedge. We observe three overall S Hmax orientations: NNE‐SSW (25° azimuth) in the deepest interval drilled at the upper slope Site U1379; ENE‐WSW (82°) in the rest of Site U1379 and in Site U1413, also drilled in the upper slope; and NNW‐SSE (157°) in the mid‐slope Site U1378. Our preferred interpretation is that the deepest interval of Site U1379 records the stress conditions in the underlying margin wedge, as S Hmax is parallel to the direction of the Cocos‐Caribbean plate convergence and of the compressional axes of plate boundary fault earthquakes. The variable S Hmax directions observed elsewhere are likely due to the effect of a network of normal faults that subdivide the sediment cover into a number of independently deforming blocks. In addition, the observed S Hmax directions may be influenced by the subducting Cocos Ridge, which acts as an indenter causing oblique deformation, and by the transition to seismogenic subduction along the plate boundary fault.
Differential CD4+ and CD8+ T cell recognition of mycobacteria antigens in pediatric versus adult TB (2022)

Abstract T cells from young children may be limited in capacity to mount pro-inflammatory responses to intracellular pathogens, thus contributing to vulnerability to TB disease. We compared CD4+ and CD8+ T cell cytokine production in response to mycobacterial antigens and mitogen SEB, between Ugandan children &lt;5 yr (PedTB) and adults (ATB) with culture-confirmed pulmonary TB. HIV-uninfected children (n=12) and adults (n=41) had blood drawn for PBMC isolation prior to TB treatment. CD4+ and CD8+ T cell production of IFNγ, IL2, and TNFα in response to ESAT6/CFP10 (EC), ESXJ, PE12/13, PE3, PPE15, and PPE51 peptide pools, and SEB, were assessed by intracellular flow cytometry. Proportions and frequencies of CD4+ and CD8+ T cells producing cytokines were compared using Fisher’s Exact and Kruskal-Wallis tests, respectively, with adjusted p-values &lt;0.05 significant. PedTB and ATB had equivalent CD4+ and CD8+ T cell production of IFNγ, IL2, and TNFα, including polyfunctional responses, to EC. T cell cytokine responses to ESXJ and PPE51 were equivalent; significant differences were noted in CD4+ T cell responses to PE3 and PPE15, and CD8+ T cell responses to PE12/13. Frequencies of CD4+ T cells producing IFNγ or IL2 in response to SEB were lower (p&lt;0.0001) in PedTB versus ATB. Young children with PedTB exhibited adult-like capacity to generate Th-1 cytokines in response to EC, ESXJ, and PPE 51. Pediatric responses to PE3, PPE15, and PE12/13 were impaired, suggesting that the breath of antigen recognition differs between infants and adults with TB. Differential T cell recognition of mycobacterial antigens between adults and children should be considered in development of novel T cell based diagnostics and vaccines targeting pediatric TB. Supporting from grants by NIH: AI157807; HHSN272200900053C
Insomnia in men treated with radical prostatectomy for prostate cancer (2004)

This study assessed the prevalence, clinical characteristics and risk factors for insomnia in patients treated with radical prostatectomy for prostate cancer. A total of 327 patients completed a battery of questionnaires assessing sleep and related issues (i.e. anxiety, depression, fatigue, quality of life). Results indicated that 31.5% of the patients currently reported non-specific sleep difficulties, while 18% met specific criteria for an insomnia syndrome. In most of these latter cases (95%), the insomnia was chronic (duration of 6 months or more). Nearly half of patients with an insomnia syndrome reported that the onset of their sleep difficulties followed the cancer diagnosis. A similar proportion had no comorbid clinical levels of anxiety or depression. Risk factors for the presence of an insomnia syndrome included a younger age, a worse prognosis, and the presence of intestinal, pain, depressive, and androgen blockade-related symptoms. Thus, insomnia is a frequent problem associated with prostate cancer, that often occurs independently of anxiety and depression, but seems to be influenced by the presence of physical and psychological symptoms associated with prostate cancer and its treatment.