gebhart/patrepeval huggingface dataset:
Electric Field Assisted Sintering of Cubic Zirconia at 390°C (2013)

Using the flash sintering technique, cubic yttria‐stabilized zirconia is shown to sinter at 390°C, more than 1000°C below nominal sintering temperatures, by using a DC electric field of 2250 V/cm. Furthermore, flash sintering experiments performed with electric fields between 60 and 2250 V/cm were used to show that the relationship of the temperature at the onset of flash sintering ( T Onset ) and the applied field (E) follows the power relationship T Onset ( K ) = 2440 E −1/5.85 (V/cm). Using this relationship, and considering the sintering of the sample in the absence of an electric field, the critical electric field to enter the flash sintering regime is shown to be 24.5 V/cm. For electric fields between this critical electric field and 2250 V/cm, the onset of flash sintering occurs in the same range of critical volumetric power dissipation, between 1 and 10 mW/mm 3 , suggesting this is a material property. Despite the volumetric power dissipation being the critical value for the onset of flash sintering behavior, the current density achieved during sintering appears to be more critical for densification rather than maximizing power dissipation.
On the Possibilities of Brownout Mitigation Using a Slotted-Tip Rotor Blade (2011)

The development of brownout dust clouds generated by rotor blades with rectangular and slotted tips was predicted using a Lagrangian-Lagrangian model. The slotted-tip is comprised of four internal slots at the leading edge near the tip that are connected to the side edge, and are designed to inject small-scale vorticity and turbulence to rapidly diffuse the vortex core. The effects of the rectangular and slotted-tip blades on a rotor in ground effect operation was modeled by using a Lagrangian free-vortex method combined with a semi-empirical model for the vortex core growth in terms of the initial core radius and turbulent diffusion rate for each blade. The more diffused tip vortices trailed from the slotted-tip were found to create lower velocities and velocity excursions at the ground than was obtained with the rectangular blade, a result also verified experimentally. The Lagrangian dust cloud model predicted a significant reduction in dust uplift by means of all of the primary entrainment mechanisms that were modeled. The development of the dust cloud in the pilot’s field of view was also found to be slower, and the overall density of the brownout cloud in these regions was lower than with the rectangular blade. This outcome suggested better ground visibility for the pilot and, therefore, a more benign dust cloud was produced using the rotor with the slotted-tip blade. Overall, the results obtained thus far have shown that the slotted-tip blade has great potential for mitigating the severity of brownout conditions.
Laminated Paper-Based Analytical Devices (LPAD) with Origami-Enabled Chemiluminescence Immunoassay for Cotinine Detection in Mouse Serum (2013)

Laminated paper-based analytical devices (LPAD) with origami-enabled chemiluminescence immunoassay have been developed for the detection of cotinine, a secondhand smoke (SHS) biomarker. The devices were fabricated by a craft-cutter to define flow channels, followed by lamination. This approach of cutting/lamination to fabricate LPAD is very similar to making an identification card, offering advantages in simplicity and rugged backing when compared to the common method of patterning paper using SU-8 or wax. We also developed a protocol of localized incision and paper-folding to isolate the detection zone from flow channels; the simple origami step eliminated possible reagent diffusion and flow during antibody immobilization steps and numerous washings. By incorporating luminol-based chemiluminescence for detecting horseradish peroxidase-conjugated cotinine, we employed origami-enabled LPAD to detect cotinine in mouse serum using competitive immunoassay. The detection limit was determined to be 5 ng/mL, a clinically relevant concentration. We believe that LPAD with chemiluminescence detection provides a new platform of low cost and sensitive assays for cotinine detection.
Studies on the mechanism of action of dioctyl sodium sulphosuccinate in the human jejunum. (1985)

An intestinal perfusion technique has been used to investigate the mechanism of action of the laxative, dioctyl sodium sulphosuccinate, in the human jejunum. Dioctyl sodium sulphosuccinate stimulated net secretion of water, sodium, chloride and potassium and inhibited net absorption of glucose and bicarbonate. These changes in water and solute transport were partially reversed by administration of indomethacin (4 mg/kg/day orally for three days), which suggests that they are mediated in part by endogenous prostaglandins.
CYP3A4 Is a Vitamin D-24- and 25-Hydroxylase: Analysis of Structure Function by Site-Directed Mutagenesis (2005)

Studies were performed to identify the microsomal enzyme that 24-hydroxylates vitamin D, whether 25-hydroxylation occurs, and structure function of the enzyme. Sixteen hepatic recombinant microsomal cytochrome P450 enzymes expressed in baculovirus-infected insect cells were screened for 24-hydroxylase activity. CYP3A4, a vitamin D-25-hydroxylase, and CYP1A1 had the highest 24-hydroxylase activity with 1 alpha-hydroxyvitamin D(2) (1 alpha OHD(2)) as substrate. The ratio of rates of 24-hydroxylation of 1 alpha-hydroxyvitamin D(3) (1 alpha OHD(3)), 1 alpha OHD(2), and vitamin D(2) by CYP3A4 was 3.6/2.8/1.0. Structures of 24-hydroxyvitamin D(2), 1,24(S)-dihydroxyvitamin D(2), and 1,24-dihydroxyvitamin D(3) were confirmed by HPLC and gas chromatography retention time and mass spectroscopy. In characterized human liver microsomes, 24-hydroxylation of 1 alpha OHD(2) by CYP3A4 correlated significantly with 6 beta-hydroxylation of testosterone, a marker of CYP3A4 activity. 24-Hydroxylase activity in recombinant CYP3A4 and pooled human liver microsomes showed dose-dependent inhibition by ketoconazole, troleandomycin, alpha-naphthoflavone, and isoniazid, known inhibitors of CYP3A4. Rates of 24- and 25-hydroxylation of 1 alpha OHD(2) and 1 alpha OHD(3) were determined in recombinant wild-type CYP3A4 and site-directed mutants and naturally occurring variants expressed in Escherichia coli. Substitution of residues showed the most prominent alterations of function at residues 119, 120, 301, 305, and 479. Thus, CYP3A4 is both a 24- and 25-hydroxylase for vitamin D(2), 1 alpha OHD(2), and 1 alpha OHD(3).
Angiotensin‐Converting Enzyme Inhibitors and Cough: A Prospective Evaluation in Hypertension and in Congestive Heart Failure (1994)

Angiotensin-converting enzyme inhibitors (ACE-I) have become the mainstem of antihypertensive therapy and first-choice agents for vasodilatation in congestive heart failure (CHF). A typical dry cough is the main cause for discontinuation of ACE-I therapy. Data about the incidence, course, and clinical significance of this side effect are conflicting. This study determined the incidence of cough in ACE-I treated patients with hypertension and with CHF and to appreciate its clinical significance; 268 ACE-I treated patients, 164 with hypertension and 104 with CHF were prospectively followed for at least 1 year and specifically questioned about cough and other side effects. In those in whom cough developed, a second and then a third ACE-I were tried. Cough developed in 50 (18.6%) of the 268 patients; 23 patients with hypertension (14%) had coughs 24.7 +/- 17.1 (SD) weeks after initiation of therapy; 27 patients with CHF (26%) had coughs 12.3 +/- 12 (SD) weeks after the start of ACE-I therapy (P = 0.005). All but three patients had coughs also on the second and third ACE-I. The time from the beginning of therapy to the onset of cough was significantly shorter with the second than the first drug. ACE-I agents had to be discontinued in 50% of the patients in whom coughs developed, most of them in the CHF group. In the others, cough was well tolerated or disappeared during subsequent months. The incidence of cough, which necessitated discontinuation of ACE-I treatment, was 4% among patients with hypertension and 18% among patients with CHF (P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
Fast, faster, fastest... : fulfillment as a competitive advantage (2015)

Almost every company is working to reduce the time it takes to get an order to a customer's how and replenish its stores. But while faster fulfillment and small order sizes make marketing, customers, and store managers happy, that faster fulfillment comes at a cost. Companies that take the time to build a business case for faster fulfillment often find the benefits far outweigh the investment costs.
Reactivity Controlled Compression Ignition Drive Cycle Emissions and Fuel Economy Estimations Using Vehicle Systems Simulations with E30 and ULSD (2014)

<div class="section abstract"><div class="htmlview paragraph">In-cylinder blending of gasoline and diesel to achieve reactivity controlled compression ignition (RCCI) has been shown to reduce NO<sub>X</sub> and PM emissions while maintaining or improving brake thermal efficiency as compared to conventional diesel combustion (CDC). The RCCI concept has an advantage over many advanced combustion strategies in that the fuel reactivity can be tailored to the engine speed and load allowing stable low-temperature combustion to be extended over more of the light-duty drive cycle load range. However, the current range of the experimental RCCI engine map investigated here does not allow for RCCI operation over the entirety of some drive cycles and may require a multi-mode strategy where the engine switches from RCCI to CDC when speed and load fall outside of the RCCI range. The potential for RCCI to reduce drive cycle fuel economy and emissions is explored here by simulating the fuel economy and emissions for a multi-mode RCCI-enabled vehicle operating over a variety of U.S. drive cycles using experimental engine maps for multi-mode RCCI with E30 and ULSD, CDC and a variety of 2009 port-fuel injected (PFI) gasoline engines ranging from 1.8L to 4.0L. Simulations are completed assuming a conventional mid-size passenger vehicle with an automatic transmission that is optimized for each engine. RCCI fuel economy simulation results are compared to the same vehicle powered by a representative 2009 PFI gasoline engine over multiple drive cycles and showing at least a 20% improvement in fuel economy over a PFI baseline. Engine-out drive cycle emissions are compared to CDC and observations regarding relative gasoline and diesel tank sizes needed for the various drive cycles are also summarized.</div></div>
A geosynchronous lidar system for atmospheric winds and moisture measurements (2002)

An observing system comprised of two lidars in geosynchronous orbit would enable the synoptic and meso-scale measurement of atmospheric winds and moisture, both of which are key first-order variables of the Earth's weather equation. Simultaneous measurement of these parameters at fast revisit rates promises large advancements in our weather prediction skills. Such capabilities would be unprecedented and (a) yield greatly improved and finer resolution initial conditions for models, (b) make existing costly and cumbersome measurement approaches obsolete, and (c) obviate the use of numerical techniques needed to correct data obtained using present observing systems. Additionally, simultaneous synoptic wind and moisture observations would lead to improvements in model parameterizations, and in our knowledge of small-scale weather processes. Technology and science data product assessments are ongoing.
Two-Factor Fuzzy Commitment for Unmanned IoT Devices Security (2018)

To create an environment for IoT devices, securely, it is necessary to establish a cryptographic key for those devices. Conventionally, this key has been stored on the actual device, but this leaves the key vulnerable to physical attacks in the IoT environment. To solve this problem, several research studies have been conducted on how best to conceal the cryptographic key. Recently, these studies have most often focused on generating the key dynamically from noisy data using a fuzzy extractor or providing secure storage using a fuzzy commitment. Thus, far, all of these studies use only one type of noisy source data, such as biometric data or physical unclonable function (PUF). However, since most IoT devices are operated in unmanned environments, where biometric data is unavailable, the method using biometric data cannot be utilized for unmanned IoT devices. Although the method using PUF is applied to these unmanned devices, these are still vulnerable against physical attacks including unintended move or theft. In this paper, we present a novel way to use the fuzzy commitment on such devices, called two-factor fuzzy commitment scheme. The proposed method utilizes two noisy factors from the inside and outside of the IoT device. Therefore, although an attacker acquiring the IoT device can access the internal noisy source, the attacker cannot extract the right key from that information only. We also give a prototype implementation for ensuring the feasibility of our two-factor fuzzy commitment concept by utilizing the image data and PUF data for two noisy factors.
Morphology of Block Copolymer Droplets on a Flat Substrate (2010)

We study the equilibrium morphology of a droplet of symmetric AB diblock copolymer on a flat substrate. A previous experiment [A. B. Croll et al. Phys. Rev. Lett., 97, 204502 (2006)] has reported conical-shaped droplets with a terraced surface. Using self-consistent field theory (SCFT), we provide the first predictions for the equilibrium droplet shape and its internal structure. When the substrate affinity for the A component, ??A, is small, the droplet adopts a nearly spherical shape much like that of simple fluids. Inside the spherical droplet, however, the block copolymer molecules acquire an ordered morphology consisting of concentric circular lamellar layers stacked on top of each other; hence the thickness of the droplet is effectively quantized by a half-integer or integer number of layers. At larger ??A and smaller contact angle, the area of the upper-most layer becomes relatively large resulting in a nearly flat, faceted top surface, followed by a semi-spherical slope. This geometry is remarkably reminiscent of the droplet shapes observed for smectic liquid crystals.
An intronic enhancer containing an N-box motif is required for synapse- and tissue-specific expression of the acetylcholinesterase gene in skeletal muscle fibers (1999)

mRNAs encoding acetylcholinesterase (AChE; EC 3.1.1.7) are highly concentrated within the postsynaptic sarcoplasm of adult skeletal muscle fibers, where their expression is markedly influenced by nerve-evoked electrical activity and trophic factors. To determine whether transcriptional regulatory mechanisms account for the synaptic accumulation of AChE transcripts at the mammalian neuromuscular synapse, we cloned a 5.3-kb DNA fragment that contained the 5' regulatory region of the rat AChE gene and generated several constructs in which AChE promoter fragments were placed upstream of the reporter gene lacZ and a nuclear localization signal (nls). Using a recently described transient expression assay system in intact skeletal muscle, we show that this AChE promoter fragment directs the synapse-specific expression of the reporter gene. Deletion analysis revealed that a 499-bp fragment located in the first intron of the AChE gene is essential for expression in muscle fibers. Further analysis showed that sequences contained within this intronic fragment were (i) functionally independent of position and orientation and (ii) inactive in hematopoietic cells. Disruption of an N-box motif located within this DNA fragment reduced by more than 80% the expression of the reporter gene in muscle fibers. In contrast, mutation of an adjacent CArG element had no effect on nlsLacZ expression. Taken together, these results indicate that a muscle-specific enhancer is present within the first intron of the AChE gene and that an intronic N-box is essential for the regulation of AChE along skeletal muscle fibers.
PREDICTION OF STOPPING MANOEUVRES (1990)

From the preceding experience, it has been concluded that numerical simulation of stopping manoeuvres can be satisfactorily estimated in deep water provided that the various hydrodynamic data relating to stopping manoeuvres are available. However, the usefulness of numerical simulation in shallow water has hardly been examined in shallow water. Therefore, the various captive model tests have been carried out to clarify the effects of finite water depth on hydrodynamic lateral forces and effective brake force induced by reverse rotation of propeller. Secondly, a number of free running model tests have been conducted to establish the difference between stopping manoeuvres in deep and shallow water. The usefulness of numerical simulation is also examined.
How predictable is the current perpendicular to plane magnetoresistance? (invited) (1996)

Prior measurements of the current perpendicular to the layer planes (CPP) resistances, taken on Co/Cu/Py/Cu (Py=Ni84Fe16) multilayers with a single pair of Co and Py thicknesses, are extended to three additional pairs of thicknesses. The same parameters, obtained from independent measurements on Co/Cu and Py/Cu multilayers that fit the original pair reasonably well, fit the three new pairs almost as well, from which we conclude that there is substantial predictability in the CPP magnetoresistance (MR). Because the predictability is not perfect, we examine the extent to which we can improve the fits to the Co/Cu/Py/Cu data by varying the Py/Cu and Co/Cu parameters within their uncertainties, without substantially weakening the fits to the original Co/Cu and Py/Cu data. We conclude by presenting the first CPP-MR measurements on Co/Ag/Py/Ag multilayers. The data are similar to those for Co/Cu/Py/Cu multilayers, but the Co/Ag/Py/Ag MRs are noticeably larger.
The Leukocyte Count as a Predictor of Myocardial Infarction (1974)

The multiphasic-examination findings of 464 persons in whom a first myocardial infarction later developed were compared with those of two control groups, one matched for age, sex and race (ordinary controls), and the other matched in addition for standard coronary risk factors (risk controls). The total leukocyte count, measured, on the average, 16.8 months before the myocardial infarction, was strikingly related to development of infarction. The mean leukocyte count in cases was significantly higher (p<0.001) than in either control group. Ascending from lowest to highest quartile in the cases and ordinary controls the increase in risk of myocardial infarction associated with the leukocyte count was similar to that found for cholesterol and blood pressure. Cigarette smoking, which was strongly related to the leukocyte count, may account for about two thirds of the relation of the count to infarction. The leukocyte count may prove valuable in the routine assessment of risk of myocardial infarction. (N Engl J Med 290:1275–1278, 1974)
Synthesis and <i>in vitro‐</i>Anticancer and Antimicrobial Evaluation of Some Novel Quinoxalines Derived from 3‐Phenylquinoxaline‐2(1<i>H</i>)‐thione (2006)

Two novel series derived from 3-phenylquinoxaline-2(1H)-thione 2 and 2-(hydrazinocarbonylmethylthio)-3-phenylquinoxaline 6 have been synthesized. Eight out of twenty six new compounds were selected at the National Cancer Institute for evaluation of their in vitro-anticancer activity. Among them, compounds 3b, 3c, 4b, and 4c displayed moderate to strong growth inhibition activity against most of the tested sub-panel tumor cell lines with GI(50) 10(-5) to 10(-6 )molar concentrations. Compound 4b exhibited a significant value of percent tumor growth inhibition against breast cancer at concentration < 10(-8) M. Compound 4c showed moderate selectivity towards leukemia cell lines with GI(50) of 1.8 to 3.8 microM (selectivity ratio = 5.7). Preliminary antimicrobial testing revealed that compounds 7a, 7b, 8a, 11a, and 11b were as active as ampicillin against B. subtilis (MIC = 12.5 microg/mL). Compounds 7b and 8a were also nearly as active as ampicillin against E. coli (MIC = 12.5 microg/mL). In addition, compounds 4a, 7b, 10b, and 11a were as active as ampicillin against P. aerugenosa (MIC = 50 microg/mL). However, compounds 7b, 8a, and 10b showed mild activity against C. albicans (MIC = 50 microg/mL). The values of minimum bactericidal concentrations indicated that compounds 4a and 7b were bactericidal against B. subtilis and P. aerugenosa, respectively, while compound 10b was bactericidal against both organisms. However, compound 11a was bactericidal against E. coli, P. aerugenosa, and S. aureus.
Identification and characterization of a novel factor XIIa inhibitor in the hematophagous insect, <i>Triatoma infestans</i> (Hemiptera: Reduviidae) (2004)

Recently, we have cloned several Kazal-type serine protease inhibitors from the midgut of the Triatoma infestans bug. A single gene composed of multi Kazal-type domains, in tandem, encodes these inhibitors. In this work, we describe the purification and characterization of recombinant infestins 3-4 and 4, which are potent factor XIIa inhibitors (KI=67 pM and 128 pM, respectively). We also identified the first native factor XIIa inhibitor from a hematophagous insect. The factor XIIa inhibitory activity of infestin 4 demonstrates extremely efficient anticoagulant activity, prolonging activated partial thromboplastin time by approximately 3 times. Our results suggest that infestins perform a very important role in the T. infestans midgut during meal acquisition and digestion by controlling blood coagulation by means of inhibiting thrombin and factor XIIa.
Learning based Dynamic Codebook Selection for Analog Beamforming (2020)

In this paper, a dynamic codebook selection scheme is proposed for beam sweeping at millimeter wave receiver. The codebook selection problem is formulated as a Partially Observed Markov Decision Process (POMDP) and Q-learning method is used to learn a policy to dynamically select an appropriate codebook from a pre-defined codebook set in each beam sweeping period. A hierarchical structure codebook set design method based on Lloyd's method is proposed to generate a proper codebook set with good coverage and high average beamforming gain. The proposed scheme offers more than 1 dB gain in terms of block error rate (BLER) performance compared with the existing methods which use a fixed codebook in all beam sweeping periods.
Electron Diffraction Study of a Pyroelectric Tourmaline Crystal (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. Yamaguchi; Electron Diffraction Study of a Pyroelectric Tourmaline Crystal. J. Appl. Phys. 1 May 1964; 35 (5): 1654–1655. https://doi.org/10.1063/1.1713711 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search