gebhart/patrepeval huggingface dataset:
PREVENTION AND REVERSAL OF ISOLATION-INDUCED SYSTOLIC ARTERIAL HYPERTENSION IN RATS BY TREATMENT WITH β-ADRENOCEPTOR ANTAGONISTS (1979)

1 Rats were made hypertensive by 5 days of continuous isolation in glass metabolic cages; in the text ‘hypertensive’ means having a systolic blood pressure greater than 145 mmHg. 2 Daily intraperitoneal injections of either propranolol (5 mg/kg) or atenolol (5 mg/kg) reduced systolic blood pressure within 3 days and the systolic blood pressure remained low provided that the treatment was continued. 3 Treatment with metoprolol also lowered the systolic blood pressure of isolated rats but only when a larger dose (10 mg/kg) was given. 4 Systolic blood pressure returned to hypertensive levels following withdrawal of treatment after 15 days of isolation. However, following cessation of treatment after 27 days of isolation, the systolic blood pressure did not rise. 5 Rats given propranolol in the drinking water (intake equivalent to a daily dose of 5 mg/kg) before and during isolation did not develop hypertension. 6 The possibility that suppression of sympathetic function by the β-adrenoceptor antagonists was responsible for these changes is discussed.
Appendix 1: Damping of a Usual Automotive Suspension (2014)

Damping of a Usual Automotive Suspension A1.1. The usual automotive suspensionLet a suspension be of type mass-spring-dashpot configured, through its variables, according to two operating states: the free state (Figure A1.1(a)) and the forced state (Figure A1.1(b), where M represents the bodywork mass supported per wheel, k denotes the spring stiffness and C denotes the viscous friction coefficient of the dashpot.In the first configuration, through the wheel (on the ground) without vertical motion, the suspension is a free system with one variable, i.e. the output variable () yt that represents the vertical displacement of the bodywork.In the second configuration, through the wheel in vertical motion, the suspension is a forced (or controlled) system with two variables: the input variable () xt that represents the wheel vertical displacement and the output variable () yt that represents the bodywork vertical displacement (in response to the one of the wheel).
SMART 7: recent updates to the protein domain annotation resource (2011)

SMART (Simple Modular Architecture Research Tool) is an online resource (http://smart.embl.de/) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 7 contains manually curated models for 1009 protein domains, 200 more than in the previous version. The current release introduces several novel features and a streamlined user interface resulting in a faster and more comfortable workflow. The underlying protein databases were greatly expanded, resulting in a 2-fold increase in number of annotated domains and features. The database of completely sequenced genomes now includes 1133 species, compared to 630 in the previous release. Domain architecture analysis results can now be exported and visualized through the iTOL phylogenetic tree viewer. 'metaSMART' was introduced as a novel subresource dedicated to the exploration and analysis of domain architectures in various metagenomics data sets. An advanced full text search engine was implemented, covering the complete annotations for SMART and Pfam domains, as well as the complete set of protein descriptions, allowing users to quickly find relevant information.
Synthesis and Antibacterial Activity of Novel Oxazolidinones Bearing N‐Hydroxyacetamidine Substituent. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cellular sociology applied to neuroendocrine tumors of the lung: quantitative model of neoplastic architecture (1996)

This paper reports on cellular sociology, which consists of modeling tissular architecture based on graph theory. Voronoi's diagram was chosen to build the models. This diagram derives from a cell neighborhood concept and generates parameters which objectively represent tissue architecture. Minimal spanning tree (MST) is probably the more frequently used among graphs and successfully discriminates different grades of pathological process. However, Voronoi's diagram is more comprehensive and a more complete representation of architecture with the advantage of stability. The lung neuroendocrine tumor classification is far from being consensual, especially for lesions which don't fall in with typical carcinoid and small cell carcinoma groups. By comparing architectural models of 20 neuroendrocrine tumors of the lung, this work supports the morphologic spectrum concept of these tumors and also supports the recently proposed concept of large-cell neuroendocrine tumors of the lung. Finally, architectural parameters separate small-cell-lung carcinomas from neuroendocrine non-small-cell lung carcinomas. © 1996 Wiley-Liss, Inc.
Soldiers in the Tropics; Cartoon of the Month - Sapajou: "... rules the waves" (1944)

Lt. Genera, Army Surgeon General, Head of Medical Bureau of the Imperial Japanese Army on moral and physical stamina of Japanese troops; Sapajou = nom-de-plume of Georgii Avksent�ievich Sapojinikoff, cartoonist with the North-China Daily News
<title>Reduction of coding artifacts in subband coders using adaptive filter banks</title> (1993)

This paper deals with still image subband coding with adaptive filter banks. Based on an analysis of distortions in coders with fixed filter banks with different characteristics, the scheme with spatially adaptive filter banks is developed. The main objective is to construct a subband coder in which both ringing noise and blocking artifacts are reduced. With respect to local image characteristics, suitable filter responses are selected to achieve this aim. The selection is based on measuring of edge business and edge orientation. A second objective is to reduce border distortions caused by the circular extension method by employing filters with short unit pulse responses in the border regions. It turns out that subband coding with adaptive filter banks in combination with an optimum filter selection strategy achieves a good trade-off between ringing noise and blocking effects. We conclude that the presented scheme for automatic filter selection works well for a large class of images with reasonably high contrast. For 'smooth-looking' images further work to improve the robustness of the algorithm is needed. The use of adaptive filtering in the image border regions solves--to some extent--the distortion problems encountered when using the circular extension method.
ENZYME-BASED DETECTION OF ESCHERICHIA COLI (2004)

A chemiluminescence assay for detection of coliforms was developed based on the reaction of .-galactosidaseenzyme from Escherichia coli with a phenylgalactosidase-substituted dioxetane substrate, leading to the generation of lightat 530 nm. Polymixin B was added to increase cell membrane permeability. Light emitted from the reaction was measuredin a luminometer, and data were correlated with counts of E. coli enumerated on MacConkey agar plates. A comparison oflight intensity from cultures grown in nutrient broth and lactose broth (LB) showed LB to be a better choice as growth medium.A randomized block design analysis comprising a two-way treatment structure with six dilution levels and 25, 50, or 55 .Lof E. coli culture indicated maximum sensitivity of the assay at 55 .L of E. coli with 500 .L of the dioxetane substrate. Anexponential increase in the intensity of light emitted was observed with an exponential increase in numbers of E. coli. Thedetection limit for the assay was 102 to 103 CFU in 60 min. The assay was able to detect the presence of coliforms in milk,sprouts, and water samples tested, as confirmed by plating the samples on MacConkey agar. With further testing, thisenzyme-based chemiluminescence assay may provide a simple and rapid method for detection of E. coli contamination infood and water.
Structural analysis and immunogenicity of Pseudomonas aeruginosa immunotype 2 high molecular weight polysaccharide. (1986)

We analyzed high molecular weight polysaccharide (PS) from the Fisher immunotype 2 (IT-2) strain of Pseudomonas aeruginosa for molecular composition and structure, then determined its immunogenicity in healthy adults. The PS was composed of 2-acetamido-2,6-dideoxygalactose (N-acetyl fucosamine) and glucose in a molar ratio of 2:1. Structural analysis by carbon-13 and proton nuclear magnetic resonance confirmed that the high molecular weight PS was structurally identical to that of the O-specific side chain of the lipopolysaccharide. PS differed from this material in molecular size. Immunization of 19 adult volunteers with doses of 50-100 micrograms of PS resulted in significant rises (P less than 0.04-P less than 0.0001) in binding antibody levels and killing antibody titers 2 and 4 wk postimmunization. The only reaction to the vaccine was localized tenderness at the immunization site. Analysis of the immunoglobulin isotype response to the vaccine showed a rise in specific serum IgG and IgA antibodies. Heterologous responses to other P. aeruginosa PS antigens were not seen. The antibody levels attained by vaccination were comparable with those in acute-phase serum samples of patients who survived sepsis with IT-2 P. aeruginosa and were significantly higher (P less than 0.03) than specific antibody levels in bacteremic patients who died. These results confirm that PS is a high molecular weight, immunogenic form of the P. aeruginosa IT-2 serotype antigen, eliciting levels of type-specific antibody comparable with those seen among patients surviving an episode of P. aeruginosa sepsis.
Technical and Economic Analyses of Poultry Production in the UAE: Utilizing an Evaluation of Poultry Industry Feeds and a Cross-section Survey (2014)

The project objective is to closely investigate select UAE poultry industry production issues as well as technical and marketing aspects. A comprehensive cross-sectional survey was conducted of UAE poultry farms using PDA (Portable Data Assistant) technology. Study objectives include: (1) obtaining baseline information on existing broiler and layer farm subsectors; (2) quantifying the amount of input used in the production process and the outputs obtained, and to identify some main and by-products that might have some economic value; (3) and assessment of feed-utilization produced by the feed industry. Economic characteristics of a typical poultry farm in UAE include: average broiler production at about 2,880 tons; average layer production at about 49 million eggs; and feed cost share of the average farm's operational cost estimated at 95%. This indicates the importance of expanding investment in UAE poultry sector. Efficiency of feed utilization of birds fed feeds from one company was slightly better (1.68 vs. 1.71) than birds fed feeds from the other company. Feed utilization efficiency of selected major feed producers in the UAE could meet the standards of high quality, commonly used meat-type strains. Such results are useful to the decision-maker at both the farm and policy levels.
Leading Edge Separation Bubbles on Turbomachine Blades (1993)

Results are presented for separation bubbles of the type which can form near the leading edges of thin compressor or turbine blades. These often occur when the incidence is such that the stagnation point is not on the nose of the aerofoil. Tests were carried out at low speed on a single aerofoil to simulate the range of conditions found on compressor blades. Both circular and elliptic shapes of leading edge were tested. Results are presented for a range of incidence, Reynolds number and turbulence intensity and scale. The principal quantitative measurements presented are the pressure distributions in the leading edge and bubble region, as well as the boundary layer properties at a fixed distance downstream where most of the flows had reattached. Reynolds number was found to have a comparatively small influence, but a raised level of freestream turbulence has a striking effect, shortening or eliminating the bubble and increasing the magnitude of the suction spike. Increased freestream turbulence also reduces the boundary layer thickness and shape parameter after the bubble. Some explanations of the processes are outlined.
Drug Discovery in Oncology (2004)

A deeper understanding of the molecular events leading to tumour formation, invasion, angiogenesis, and metastasis has provided a new mechanistic basis for oncology drug discovery: targeted anticancer therapy. By specifically blocking the molecular pathways implicated in the pathogenesis of cancer, targeted anticancer agents are expected to alter the natural course of the disease and, at the same time, to offer an enhanced therapeutic index over traditional cytotoxic agents. Following this new paradigm, extracellular matrix remodelling enzymes, growth-factor receptors, signal transduction proteins, and regulators of cell-cycle and gene expression have been the subject of intense drug discovery activities. Three representative areas of research in which targeted cancer therapy has advanced with some success have been selected to briefly illustrate the current status and some of the challenges of drug discovery in oncology.
[Symptomatic vesicoureteral reflux in kidney transplantation: results of endoscopic injections of teflon and predictive factors for success]. (2003)

Endoscopic treatment of symptomatic vesicoureteric reflux on a transplanted kidney by Teflon injection is effective in two-thirds of cases. Due to the low morbidity of this minimally invasive procedure, this treatment should be proposed as first-line management for all cases of symptomatic vesicoureteric reflux on a transplanted kidney.
Recombinant<i>Saccharomyces cerevisiae</i>Expressing P450 in Artificial Digestive Systems: a Model for Biodetoxication in the Human Digestive Environment (2003)

The use of genetically engineered microorganisms such as bacteria or yeasts as live vehicles to carry out bioconversion directly in the digestive environment is an important challenge for the development of innovative biodrugs. A system that mimics the human gastrointestinal tract was combined with a computer simulation to evaluate the survival rate and cinnamate 4-hydroxylase activity of a recombinant model of Saccharomyces cerevisiae expressing the plant P450 73A1. The yeasts showed a high level of resistance to gastric and small intestinal secretions (survival rate after 4 h of digestion, 95.6% +/- 10.1% [n = 4]) but were more sensitive to the colonic conditions (survival rate after 4 h of incubation, 35.9% +/- 2.7% [n = 3]). For the first time, the ability of recombinant S. cerevisiae to carry out a bioconversion reaction has been demonstrated throughout the gastrointestinal tract. In the gastric-small intestinal system, 41.0% +/- 5.8% (n = 3) of the ingested trans-cinnamic acid was converted into p-coumaric acid after 4 h of digestion, as well as 8.9% +/- 1.6% (n = 3) in the stomach, 13.8% +/- 3.3% (n = 3) in the duodenum, 11.8% +/- 3.4% (n = 3) in the jejunum, and 6.5% +/- 1.0% (n = 3) in the ileum. In the large intestinal system, cinnamate 4-hydroxylase activity was detected but was too weak to be quantified. These results suggest that S. cerevisiae may afford a useful host for the development of biodrugs and may provide an innovative system for the prevention or treatment of diseases that escape classical drug action. In particular, yeasts may provide a suitable vector for biodetoxication in the digestive environment.
DEVELOPMENT OF AN IMPROVED SIMULATOR FOR CHEMICAL AND MICROBIAL IOR METHODS (2001)

This is the final report of a three-year research project on further development of a chemical and microbial improved oil recovery reservoir simulator. The objective of this research was to extend the capability of an existing simulator (UTCHEM) to improved oil recovery methods which use surfactants, polymers, gels, alkaline chemicals, microorganisms and foam as well as various combinations of these in both conventional and naturally fractured oil reservoirs. The first task was the addition of a dual-porosity model for chemical IOR in naturally fractured oil reservoirs. They formulated and implemented a multiphase, multicomponent dual porosity model for enhanced oil recovery from naturally fractured reservoirs. The multiphase dual porosity model was tested against analytical solutions, coreflood data, and commercial simulators. The second task was the addition of a foam model. They implemented a semi-empirical surfactant/foam model in UTCHEM and validated the foam model by comparison with published laboratory data. The third task addressed several numerical and coding enhancements that will greatly improve its versatility and performance. Major enhancements were made in UTCHEM output files and memory management. A graphical user interface to set up the simulation input and to process the output data on a Windows PC was developed. New solvers for solving the pressure equation and geochemical system of equations were implemented and tested. A corner point grid geometry option for gridding complex reservoirs was implemented and tested. Enhancements of physical property models for both chemical and microbial IOR simulations were included in the final task of this proposal. Additional options for calculating the physical properties such as relative permeability and capillary pressure were added. A microbiological population model was developed and incorporated into UTCHEM. They have applied the model to microbial enhanced oil recovery (MEOR) processes by including the capability of permeability reduction due to biomass growth and retention. The formations of bio-products such as surfactant and polymer surfactant have also been incorporated.
Microsecond Electron Beam Diode Closure Experiments (1985)

Abstract : Experiments have been conducted on the Michigan Electron Long Beam Accelerator (MELBA) to explore diode closure and voltage compensation during collapsing diode impedance. MELBA operates with parameters: Voltage = - 0.6 to -1.0 MV; Current 60 kA; and Pulselengths exceeding 1 micro s. A reverse charged ringing circuit compensates the Marx generator output voltage to within +/- 7 % (+/- 10%) for pulselengths of 1 micro s (1.4 micro s) in a 127 ohm resistive load. Electron beam generation experiments have utilized two types of field emission cathodes: carbon brush and velvet cloth. Total electron beam pulselengths of 4 micro s have been achieved.
A lethal neonatal dwarfing condition with short ribs, polysyndactyly, cranial synostosis, cleft palate cardiovascular and urogenital anomalies and severe ossification defect (1977)

A case of severe lethal neonatal dwarfism is reported. It appears to be a new variety of short rib-polydactyly dwarfism. It is characterized by severe lack of ossification of all bones except the clavicle and the presence of cleft palate, as well as genitourinary, central nervous system and cardiovascular anomalies. Electronmicroscopy revealed accumulations of granular material in the chondrocytes.
Application of Biological Acidification to Improve the Quality and Processability of Wort Produced from 50% Raw Barley (2004)

In this study four strains of lactic acid bacteria (LAB) were chosen to bioacidify a mash containing 50% barley and 50% malt. The strains were isolated from malted and unmalted barley and assayed for extracellular enzymatic activities (proteases, amylases, β-glucanases). The biologically acidified mash was compared to a chemically acidified mash, 100% malt mash un-acidified and 50% malt and 50% barley mash unacidified. Characteristics such as pH, extract, colour, viscosity, total soluble nitrogen (TSN), free amino nitrogen (FAN), apparent fermentability, β-glucan and lautering performance of the resultant worts were determined. A model lautering system replicating one used in a brewery was designed and built in University College Cork (UCC) to measure the lautering performance of the bioacidified mashes. The new system was compared to the filtration method used in EBC method 4.5.1. Overall the addition of LAB to bioacidify a mash of 50% barley and 50% malt resulted in faster filtration times, which correlated with decreased β-glucan levels. Proteolytic LAB had a positive influence on the quality of wort and resulted in increased FAN levels. Lighter colour worts were observed along with increased extract levels.
A NEW METHOD TO CONTROL NICKEL METAL PARTICLE SIZE IN Ni/SiO2 CATALYST (1982)

Abstract Techniques to control metal particle size in a supported catalyst, where metal particles may be fixed on a support by forming chemical bonds with oxygen atoms in a support, were investigated. The effect of metal particle size on a reaction selectivity was elucidated in terms of the ratio of numbers of the edge and corner atoms to those of the surface total atoms in the metal crystallites.
Effect of starting particle size and vacuum processing on the yttrium barium copper oxide (YBa2Cu3Ox) phase formation (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of starting particle size and vacuum processing on the yttrium barium copper oxide (YBa2Cu3Ox) phase formationGideon S. Grader, P. K. Gallagher, and D. A. FlemingCite this: Chem. Mater. 1989, 1, 6, 665–668Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/cm00006a020https://doi.org/10.1021/cm00006a020research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intelligent musical instruments: The future of musical performance or the demise of the performer? (1993)

Abstract This paper examines the potential problems that “too much” technology in musical performance can create. In developing very powerful computer‐assisted instruments, and in decoupling the sound production from the gesture, issues of what performance is really about start to surface. This is a relatively recent problem, because it is only in the last few years that real‐time performance has been widely possible in computer music. As a case in point, we will discuss a recently co‐composed piece entitled “Wildlife”, that involves many of the critical issues.