gebhart/patrepeval huggingface dataset:
Antibody binding of circulating ergot alkaloids in cattle grazing tall fescue (1994)

Direct evidence linking alkaloids found in endophyte-infected tall fescue forage with the livestock disorder known as fescue toxicosis is lacking. Physiologic effects of fescue toxicosis include reduced serum prolactin concentration in cattle. A monoclonal antibody specific to the lysergic moiety of ergot alkaloids was developed in mice after creating an immunogen by linking lysergol to human serum albumin. The antibody was specific to the lysergic moiety and, therefore, it cross-reacted with ergot alkaloids, lysergic acid, and lysergol. The antibody did not cross-react with alkaloid derivatives that had bromated or hydrogenated lysergic ring moieties. Fescue toxicosis conditions were elicited in yearling Angus steers by permitting them to graze endophyte-infected tall fescue containing > 650 micrograms/kg of ergovaline for 60 days. Passive immunization of steers by infusion of the monoclonal antibody increased serum prolactin concentration by 7 ng/ml, beginning immediately after infusion. Control steers did not respond to treatment with bovine serum albumin. Active immunization of yearling Angus heifers with immunogens containing lysergol or ergonovine linked to human serum albumin resulted in an antibody response.
Polarization-multiplexed nonbinary LDPC-coded modulation with optimal signal constellations (2011)

We propose using nonbinary LDPC-coded modulation with optimal constellations obtained via iterative polar quantization (IPQ). The proposed scheme significantly outperforms its prior-art bit-interleaved LDPC-coded modulation counterpart, e.g., by 2.78 dB for the 128-point IPQ constellation.
Real-Time Breath Analysis of Vapor Phase Uptake of 1,1,1 Trichloroethane Through the Forearm: Implications for Daily Absorbed Dose of Volatile Organic Compounds at Work (1999)

(1999). Real-Time Breath Analysis of Vapor Phase Uptake of 1,1,1 Trichloroethane Through the Forearm: Implications for Daily Absorbed Dose of Volatile Organic Compounds at Work. Applied Occupational and Environmental Hygiene: Vol. 14, No. 11, pp. 719-727.
Some Effects of Chemical Composition on the Flammability Behavior of Textiles (1970)

The oxygen index method is shown to be a valuable tool for the investigation of the flammability of textile samples as a function of their chemical composition. Measurements of limiting oxygen index (LOI) are reported for polyester/cotton blends of varying composition, and for 50/50 polyester/cotton blends in which one component fiber has been selectively treated with flame-retardant additives. LOI values are also reported for cotton fabric treated with nitrogen-containing resins at various levels of nitrogen content, in conjunction with a flame-retardant additive.
2nd Generation Alkaline Electrolysis: Final report (2013)

This report provides the results of the 2nd Generation Alkaline Electrolysis project which was initiated in 2008. The project has been conducted from 2009-2012 by a consortium comprising Århus University Business and Social Science – Centre for Energy Technologies (CET (former HIRC)), Technical University of Denmark – Mechanical Engineering (DTU-ME), Technical University of Denmark – Energy Conversion (DTU-EC), FORCE Technology and GreenHydrogen.dk. The project has been supported by EUDP.
473. Volatile products of pyrolysis of nicotine (1961)

The first page of this article is displayed as the abstract.
A Compact Centrifugal Pump for Cardiopulmonary Bypass (1992)

A majority of the cardiopulmonary bypass (CPB) systems still utilize bulky roller pumps. A direct-drive small centrifugal pump intended for second-generation CPB pump has been developed. The pump has a 50 mm diameter impeller and provides a 6 L/min flow at 3,000 rpm against 300 mm Hg. A flexible drive shaft allows us to separate the pump head from the console resulting in easier manipulation. An in vitro study showed that the pump generated less hemolysis (index of hemolysis = 0.0011, comparable to the value for Bio-medicus BP-80). To improve blood flow around the shaft-seal region and to reduce thrombus formation around the shaft, six holes were drilled through the impeller. In biventricular bypass experiments using calves, our pump demonstrated excellent antithrombogenicity and durability for 48 h. And the compact and atraumatic centrifugal pump system showed excellent performance and easy manipulation under actual CPB conditions in animal.
A CD40–CD154 interaction in tissue fibrosis (2008)

The interaction between fibroblasts and mast cells or T cells through CD40-CD154 signaling is critical for fibroblast activation early in the course of fibrosis. Blockade of the CD40-CD154 signal may be a novel therapeutic strategy for human fibrotic diseases, such as SSc.
Highly Purified Eicosapentaenoic Acid as Free Fatty Acids Strongly Suppresses Polyps in ApcMin/+ Mice (2010)

Our data make 99% pure EPA-FFA an excellent candidate for CRC chemoprevention.
Predicting real-time properties of component assemblies: a scenario-simulation approach (2004)

This work addresses the problem of predicting timing properties of multitasking component assemblies during the design phase. For real-time applications, it is of vital importance to guarantee that the timing requirements of an assembly are met. We propose a simulation-based approach for predicting the real-time behaviour of an assembly based on models of its constituent components. Our approach extends the scenario-based method in [J. Muskens et al. (2004)] by offering a system model that is tailored to the domain of real-time applications. Contributions of This work include the possibility to handle the following features: mutual exclusion, combinations of aperiodic and periodic tasks and synchronization constraints. The analytical approach we used in previous work cannot handle these features. Therefore, we introduce the simulation-based approach. Our simulator provides data about dynamic resource consumption and real-time properties like response time, blocking time and number of missed deadlines per task. We have validated our approach using a video-decoder application.
Charting past, present, and future research in ubiquitous computing (2000)

The proliferation of computing into the physical world promises more than the ubiquitous availability of computing infrastructure; it suggest new paradigms of interaction inspired by constant access to information and computational capabilities. For the past decade, application-driven research on abiquitous computing (ubicomp) has pushed three interaction themes: natural interfaces, context-aware applications, and automated capture and access . To chart a course for future research in ubiquitous computing, we review the accomplishments of these efforts and point to remaining research challenges. Research in ubiquitious computing implicitly requires addressing some notion of scale, whether in the number and type of devices, the physical space of distributed computing, or the number of people using a system. We posit a new area of applications research, everyday computing, focussed on scaling interaction with respect to time. Just as pushing the availiability of computing away from the traditional desktop fundamentally changes the relationship between humans and computers, providing continuous interaction moves computing from a localized tool to a constant companion. Designing for continous interaction requires addressing interruption and reumption of intreaction, representing passages of time and providing associative storage models. Inherent in all of these interaction themes are difficult issues in the social implications of ubiquitous computing and the challenges of evaluating> ubiquitious computing research. Although cumulative experience points to lessons in privacy, security, visibility, and control, there are no simple guidelines for steering research efforts. Akin to any efforts involving new technologies, evaluation strategies form a spectrum from technology feasibility efforts to long-term use studies—but a user-centric perspective is always possible and necessary
Tissue Prothrombin (1997)

Immunohistochemical analysis of surgically obtained porcine tissue samples reveals ubiquitous staining for prothrombin in organs rich in smooth muscle content and universal staining of smooth muscle in tissue vasculature. The native character of tissue prothrombin is verified first by chromogenic substrate hydrolysis and hirudin inhibition after incubation of tissue extracts with taipan snake venom and phospholipid. Western analysis of tissue extracts confirms the native zymogen molecular weight. In addition, prothrombin purified in good yield from porcine uterus is activated by Echis carinatus venom which, like taipan venom, is 4-carboxyglutamic acid-sensitive. After correction for blood (gross heme) and interstitial fluid (albumin), excess functional prothrombin is observed in extracts of tissues having abundant smooth muscle. In contrast with factor X, the yield of prothrombin purified from porcine uterus greatly exceeds that attributable to contamination by whole blood. Northern blot analysis from selected bovine tissues extracted for polyadenylated messenger RNA is equivocal for prothrombin mRNA with the exception of liver, which is positive. It is concluded that functionally intact prothrombin is widely distributed among tissues owing to smooth muscle content, although the mechanism of emplacement and physiologic significance of prothrombin in these tissues remains unclear.
Measuring safety awareness in cooperative ITS applications (2016)

Cooperative Intelligent Transportation Systems (C-ITS) are key component of the future road traffic management system. To evaluate and analyze the reliability of various applications supported by C-ITS, realistic performance metrics are required. Such metrics serve as a performance indicator and help in tuning the wireless transmission parameters to maintain required quality of service. The essential purpose of a C-ITS is to enhance the vehicle safety awareness and hence, provide an accurate information of vehicles in the vicinity through regular sharing of cooperative awareness messages (CAMs). The existing metrics such as packet delivery ratio provide quantitative measure of vehicle safety awareness but do not consider the accuracy of received information. In this paper, we propose two novel safety awareness metrics (SAM) to enhance the measure of vehicle awareness by considering factors such as age and weight of a received CAM in the perspective of C-ITS. Using simulation results in NS-3, we show that the current metrics provide an optimistic view of vehicle safety awareness and proposed metrics serve as a valuable gauge to analyze the reliability of applications in C-ITS.
Autoreactivity to self H‐2K<sup>b</sup> peptides in TAP1<sup>–/–</sup> mice. Intravenous administration of H‐2K<sup>b</sup> class I‐derived peptides induces long‐term survival of grafts from C57BL/6 donors (2005)

We and others have previously shown that TAP1-/- mice (H-2b) reject grafts from donors without major histocompatibility complex (MHC) disparity that express wild-type levels of H-2b class I molecules (C57BL/6, TAP1+/+ mice). In this same model, we also showed that subcutaneous priming of TAP1-/- mice with synthetic peptides derived from the H-2Kb molecule accelerated graft rejection and that in vivo depletion of CD4+ T cells induced a significant prolongation of graft survival, suggesting an important role for CD4 T cells. We hypothesize that, in this model, rejection is triggered by the recognition of class I molecules or derived peptides, in an inflammatory microenvironment, by a functionally altered autoreactive T-cell repertoire that escapes the control of peripheral regulatory mechanisms. In the present study, we analysed the cellular autoreactivity induced by synthetic peptides derived from the H-2Kb sequence in naive and TAP1-/- mice transplanted with C57BL/6 grafts, and investigated whether intravenous modulation of autoreactivity to these peptides induced transplantation tolerance. We showed that TAP1-/- mice have peripheral autoreactive T cells that recognize H-2Kb peptides. A significant amplification of proliferation against these peptides was detected in TAP1-/- mice that rejected grafts, indicating that the inflammatory context of transplantation induced peripheral expansion of these autoreactive T cells. Furthermore, intravenous injection of H-2Kb-derived peptides significantly prolonged graft survival in some animals. In these mice (> 100 days graft survival), we observed intragraft inhibition of interferon-gamma and interleukin-10 expression, suggesting that these cytokines have an active role during the rejection. In conclusion, our present data indicate that inflammatory autoreactive T cells directed against H-2Kb peptides can be inhibited in the periphery to prolong graft survival in TAP1-/- mice.
All three components of the neuronal SNARE complex contribute to secretory vesicle docking (2012)

Results and discussion Cleavage of syb by
Differential regulation of myelin phagocytosis by macrophages/microglia, involvement of target myelin, Fc receptors and activation by intravenous immunoglobulins (2002)

Macrophages/microglia are the key effector cells in myelin removal. Differences exist in the amount and time course of myelin uptake in the central (CNS) and peripheral nervous system (PNS), the basis of this difference, however, is not yet clarified. In the present experiments we studied the phagocytosis rate of CNS or PNS myelin by macrophages and microglia in vitro. Additionally, the effects of intravenous immunoglobulins (IVIg) on this process were investigated. In the PNS experiments, sciatic nerves were cocultured with peritoneal macrophages. Optic nerve fragments were used to characterize the myelin-removing properties of microglia. Cocultures with peritoneal macrophages aimed at investigating the differences in phagocytosis between resident microglia and added macrophages. The myelin phagocytosis in sciatic nerve fragments was higher than in optic nerves, indicating differences in the myelin uptake rate between peripheral macrophages and microglia. IVIg increased the phagocytosis of PNS myelin by macrophages, but not by microglia in optic nerves. The addition of peritoneal macrophages to optic nerve fragments did not lead to an increase in the phagocytosis of CNS myelin either. The IVIg induced phagocytosis of PNS myelin by peripheral macrophages was associated with an increased expression of macrophage Fc receptors measured by FACS. Blocking of Fc receptors by anti-Fc receptor antibody reduced the IVIg induced PNS myelin phagocytosis to basic levels, indicating that the induced but not the basic myelin uptake by macrophages is Fc receptor dependent. In contrast to peripheral macrophages, IVIg did not increase Fc receptor density on microglia. These data indicate that phagocytosis of PNS and CNS myelin by macrophages or microglia is differentially regulated. Local factors within the CNS or PNS may affect this process by modulating the surface receptor profile and activation state of the phagocytic cell or the structure of the myelin sheath.
UROTHELIAL NEOPLASMS IN PATIENTS 20 YEARS OR YOUNGER: A CLINICOPATHOLOGICAL ANALYSIS USING THE WORLD HEALTH ORGANIZATION 2004 BLADDER CONSENSUS CLASSIFICATION (2005)

Urothelial neoplasms in individuals younger than 20 years more commonly occur in males and are predominantly low grade with a favorable clinical outcome. Before the current classification system the 10 patients with a diagnosis of PUNLMP would have been classified as having papillary carcinoma. Thus, the diagnostic category of PUNLMP allowed 43.5% of patients in this series to avoid being labeled with "cancer" at a young age.
Glass Wool Filters for Concentrating Waterborne Viruses and Agricultural Zoonotic Pathogens (2012)

The key first step in evaluating pathogen levels in suspected contaminated water is concentration. Concentration methods tend to be specific for a particular pathogen group, for example US Environmental Protection Agency Method 1623 for Giardia and Cryptosporidium1, which means multiple methods are required if the sampling program is targeting more than one pathogen group. Another drawback of current methods is the equipment can be complicated and expensive, for example the VIRADEL method with the 1MDS cartridge filter for concentrating viruses2. In this article we describe how to construct glass wool filters for concentrating waterborne pathogens. After filter elution, the concentrate is amenable to a second concentration step, such as centrifugation, followed by pathogen detection and enumeration by cultural or molecular methods. The filters have several advantages. Construction is easy and the filters can be built to any size for meeting specific sampling requirements. The filter parts are inexpensive, making it possible to collect a large number of samples without severely impacting a project budget. Large sample volumes (100s to 1,000s L) can be concentrated depending on the rate of clogging from sample turbidity. The filters are highly portable and with minimal equipment, such as a pump and flow meter, they can be implemented in the field for sampling finished drinking water, surface water, groundwater, and agricultural runoff. Lastly, glass wool filtration is effective for concentrating a variety of pathogen types so only one method is necessary. Here we report on filter effectiveness in concentrating waterborne human enterovirus, Salmonella enterica, Cryptosporidium parvum, and avian influenza virus.
Sequential detection of transient changes in stochastic systems under a sampling constraint (2015)

The problem of detecting a transient change in distribution of a discrete time series is investigated when there is a constraint on the number of observed samples. Under a minimax setting where the change time is unknown, the objective is to design a statistical test that minimizes a measure of worst case delay under a constraint on the average time to false alarm as well as a constraint on the sampling rate. Leveraging the results in the non-transient setting, it is shown that under full sampling there exists an asymptotic threshold on the minimum duration of a change that can be detected reliably with such false alarm constrained tests. Next, given a transient change with duration above this asymptotic threshold, the smallest sampling rate for which the change can be detected as efficiently as under full sampling is characterized asymptotically.
Determination of Structure of β,δ-Dihydroxy-β-methylvaleric Acid (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Structure of β,δ-Dihydroxy-β-methylvaleric AcidDonald E. Wolf, Carl H. Hoffman, Paul E. Aldrich, Helen R. Skeggs, Lemuel D. Wright, and Karl FolkersCite this: J. Am. Chem. Soc. 1957, 79, 6, 1486–1487Publication Date (Print):March 1, 1957Publication History Published online1 May 2002Published inissue 1 March 1957https://pubs.acs.org/doi/10.1021/ja01563a057https://doi.org/10.1021/ja01563a057research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
OPTIMUM ARRAY PROCESSING AND REPRESENTATION OF NONSTATIONARY RANDOM SCATTERING (Invited Paper) (1988)

'ins purpose of this paper is to extend scattering function concepts to nonstationary and correlated scattering and use appropriate extensions to study optimum array processors in inhomogeneous Gaussian random noise fields. For this end we will review common functional representations of nonstationary stochastic processes and indicate how these functional representations can be used for analysis of nonstationary scattering. Then we will give expressions for optimum (maximum likelihood for Gaussian distributions) scalar and array processors in terms of Wigner distributions. Finally, we will use Moyal's formula to derive expressions for the detection indices in terms of Wigner distributions.
Salting-Out Effect of Dipotassium Hydrogen Phosphate on the Recovery of Acetone, Butanol, and Ethanol from a Prefractionator (2014)

Dipotassium hydrogen phosphate (K2HPO4) has been investigated as an excellent salting-out agent to recover (acetone + butanol + ethanol) (ABE) from a prefractionator. The increasing additions of K2HPO4·3H2O to the ABE system under unsaturated conditons show strong salting-out effects on the ABE. This favorable salting-out effect is based on the hydration of the charged ions. The HPO42– ions may destroy the “hydration shell”, but the crescent concentrations of K2HPO4 make positive salting-out effects on the ABE. More acetone, 1-butanol, and ethanol are recovered after higher-level concentrations of K2HPO4 solution are added to the ABE system. Meanwhile, the equilibrium time shortens. A higher temperature can also make the equilibrium time shorter. The smallest amount of K2HPO4 in the organic phase causes no trouble for the (salting-out + distillation) process in an industrial application.
Synchronous infection with <i>Mycobacterium chelonae</i> and <i>Paecilomyces</i> in a heart transplant patient (2010)

A 41-year-old male who was 3 years status post heart transplant presented with a 3-month history of painful erythematous nodules and ulcers on his lower legs and right hand. First, Mycobacterium chelonae infection was revealed through several biopsies with molecular sequence analysis, and combination treatment, including clarithromycin, was started. During the treatment, lesions of the legs showed an improvement, but a fluctuant erythematous nodule on the thumb did not respond. Repetitive biopsy from the thumb ultimately identified Paecilomyces species and the patient was treated with itraconazole and terbinafine sequentially. Our case is the first report, to our knowledge, of synchronous infection with non-tuberculous mycobacteria (NTM) and Paecilomyces in a solid organ transplant recipient. Our findings highlight the importance of recognizing cutaneous NTM infections or deep mycoses, as well as the importance of choosing an appropriate treatment.
Fitting Multimodal Lognormal Size Distributions to Cascade Impactor Data (1990)

A procedure is described for fitting multimodal lognormal size distributions to cascade impactor data. The method was applied to published cascade impactor measurements for ammonium and nitrate that were previously analyzed by procedures that do not assume a functional form for the size distribution. An evaluation of the lognormal fitting procedure by Monte Carlo simulations demonstrated that unbiased parameters and reliable estimates of their uncertainties require correct specifications of measurement precision and impactor characteristics.
La mirada a la persona en la educación actual (2011)

Resumen es: En este articulo se enfatiza la dignidad de la persona en la autentica educacion. Aunque algunas concepciones pedagogicas se hayan centrado mas en la ese...