gebhart/patrepeval huggingface dataset:
Food Antigen Handling by the Gut (1981)

Food Antigen Handling by the Gut Get access R. J. LEVINSKY R. J. LEVINSKY Senior Lecturer in Immunology Institute of Child Health30 Guilford Street London WCl Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Tropical Pediatrics, Volume 27, Issue 1, February 1981, Pages 1–4, https://doi.org/10.1093/tropej/27.1.1-a Published: 01 February 1981
Natural enemies of the coffee berry borer, Hypothenemus hampei (Ferrari) (Coleoptera: Scolytidae) in Togo and Cote d'Ivoire, and other insects associated with coffee beans (1999)

A search for natural enemies of the coffee berry borer, Hypothenemus hampei (Ferrari), was conducted in Togo and Cote d'Ivoire. Several strains of the fungal entomopathogens Paecilomyces farinosus (Holm ex SF Gray) Brown and Smith and Beauveria bassiana (Balsamo) Vuillemin were found in each country. This is the first report of P. farinosus infecting coffee berry borer. Leptophloeus sp. near punctatus (Coleoptera: Laemophloeidae) was observed preying on coffee berry borer larvae for the first time. Cephalonomia stephanoderis Betrem (Hymenoptera: Bethylidae) was the most abundant coffee berry borer parasitoid found in Cote d'Ivoire followed by Phymastichus coffea LaSalle (Hymenoptera: Eulophidae). Both species also occur in Togo, although in very low numbers, together with another parasitoid, Prorops nasuta Waterston (Hymenoptera: Bethylidae). Other insects emerging from coffee beans are also reported.
Biomolecular Modulation of Neurodegenerative Events during Ageing (2015)

The objective is to assess the modulation of retinal and optic nerve degenerative events induced by the combination of α-lipoic acid (ALA) and superoxide dismutase (SOD) in an animal model of ageing. For this study, 24 male Wistar-Harlan strain rats were left to age for up to 24 months. One group of rats was subjected to a diet supplemented with ALA and SOD for 8 weeks, while another group was used as a positive control and not subjected to any dietary treatment. To assess the cytoprotective effects of the antioxidants, a morphological analysis was carried out on sections of retina and optic nerve head, stained with haematoxylin-eosin, followed by an analysis of the modifications to nuclear DNA detected by the TUNEL technique. The lipid peroxidation assay was used to assess the damage induced by oxidative stress at cell membrane level. The molecules involved in apoptosis mediated by oxidative stress, such as caspase-3 and inducible nitric oxide synthase, were also assayed by immunolocalization and western blot. ALA and SOD are able to counteract senile neurodegenerative deterioration to the retina and optic nerve. Indeed, the combination of these antioxidant molecules can reduce oxidative stress levels and thus prevent both nuclear degradation and subsequent cell death.
Identification of a promoter region for<i>mxaF</i>(<i>moxF</i>) from the type I methanotroph,<i>Methylobacter albus</i>BG8 (1994)

A fragment of Methylobacter albus BG8 DNA containing mxaF (moxF), the gene encoding the alpha subunit of methanol dehydrogenase, was previously cloned using a fragment of mxaF from Methylobacterium extorquens AM1 as a probe (Stephens et al., J. Bacteriol. (1988) 170, 2063-2069). In this study we identified the 5' portion of mxaF of M. albus BG8 and sequenced a 1.7-kb region containing the 5' portion of mxaF and 1.5 kb of upstream DNA. The deduced N-terminal amino acid sequence of mxaF was found to have very high similarity to the previously sequenced mxaF genes. The region directly upstream of mxaF was cloned into a promoter probe vector (pGD500), and promoter activity was demonstrated when the fragment was present in the correct orientation with relation to the reporter gene (lacZ). Using reverse transcriptase, the transcription initiation start site was determined, which was separated from the translation initiation site by 190 nucleotides.
Lead Systems for Atrial Defibrillation (1994)

In summary, these five studies show that electrode locations that include both left and right atrium result in lower thresholds. Thresholds from right atrium to chest wall patch are higher than thresholds from right atrium to cardiac vein, suggesting that confinement of the electric field by a transvenous electrode system is advantageous. Of the transvenous locations tested, the right atrial appendage to left atrial appendage defibrillation vector consistently had the lowest defibrillation energy threshold. The proximal coronary sinus to right atrial vector may be inappropriate due to the high thresholds observed. The large variability of the mean threshold for the obtuse marginal location in the cardiac vein vasculature suggests that this vector may result in higher thresholds in some instances. Electrode locations that have high defibrillation thresholds and are in close proximity to the sinoatrial or atrioventricular node increase the likelihood of sinus arrhythmias or conduction block following the defibrillation shocks. No difference was detected between the thresholds between the single catheter, two electrode system and the two catheter system, despite the variability of location of the electrode in the right atrium, suggesting that such a catheter may provide a simpler implantation procedure and equivalent thresholds in some patients. These findings suggest that coronary sinus/great cardiac vein catheter designs should strive for implantation in the distal portion of the great cardiac vein so that the shocking electrode underlies the left atrium with the other shocking electrode located in the right atrium.
Replacement of fluorescent lamps with high-brightness LEDs in a bridge lighting application (2006)

There are many advantages that LEDs offer for use in general illumination. The use of LEDs in certain applications can provide improved energy efficiency. For example, in traffic lights in the United States, LED technology has taken over the market not only because of the energy savings as compared to standard incandescents, but also because of the reduced maintenance costs associated with bulb replacement and improved reliability. With useful lifetimes exceeding 40,000 hours or more, today's high flux LEDs can provide illumination solutions with replacement periods of 8 to 10 years or more. This paper will examine a bridge roadway lighting feasibility study which the authors' company recently undertook. The application required the LED units to reproduce the photometric performance of 64-inch (1.625m) fluorescent lamps. In addition, the LED units were required to survive a harsh, outdoor marine environment with an expected lifetime of 7 years or more. To achieve these results, a number of design elements were studied including: optimum heat dissipation in a sealed enclosure, ease of installation, and design of power supplies having expected lifetimes to match the LED light engines. Results of these studies will be discussed as well as illustrations of the designs chosen.
Synthesis of Core-shell Nanoparticles Si-ZnS by Reactive Deposition of Photocatalytic ZnS Layer on the Surface of Carrier Si Nanoparticles in Aerosol Microdrops (2015)

In this work we report on the aerosol synthesis of photocatalytic powder nanostructures of core-shell Si-ZnS particles. Submicron Si particles were prepared in the form of an aqueous dispersion by disintegration of the semiconductor-grade silicon powder in the cavitation Water Jet Mill disintegrator. Adding zinc acetate converted aqueous dispersion medium into a solution of Zn(Ac)2 in various concentrations. The thus prepared liquid dispersion was then transformed into aerosol microdroplets with an average size of 3.5 microns in the Omron NE-U17 nebulizer. These were subsequently transported by flowing gas into the vigorously stirred aqueous solution of sodium sulfide. At impact of these aerosol “microreactors” the two liquid reactants produce zinc sulphide. Due to heterogeneous nucleation the insoluble phase of ZnS is precipitated on the phase surface of the silicon carrier particles contained in the microdroplets. As the amount of Zn(Ac)2 in a microdroplet is limited, so is the extent of the precipitation reaction and the thickness of the container can be regulated by Zn(Ac)2 concentration in the liquid dispersion. The obtained liquid dispersion of core-shell particles of Si-ZnS was dryed by controlled vacuum sublimation and stabilized in the form of lamellar nanoaggregates with a relatively high surface area. The final material enables easy handling and shows significantly higher photocatalytic activity than TiO2 Evonik P25 standard.
ELECTROCHEMICAL EVIDENCE FOR OXO-ENOL TAUTOMERISM OF AZAANTHRACENE-4,9,10-TRIONES (2000)

The redox properties of a series of 1-aza-, 1,5-diaza-and 1,8-diazaanthracene-4,9,10-triones are reported.The results obtained show that the presence of electron-withdrawing heterocyclic nitrogen atoms causes an increase of the reduction potentials, and also the expected similar effect of electron-withdrawing substituents./^-substituted derivatives exhibited a reduction at ca. -1.45 V, which is assigned to the α,β-unsaturated carbonyl system.In contrast with their 2-oxo vinylogues, 1,5-diaza-and 1,8-diazaanthracene-4,9,10-triones show three reduction potentials.On the basis of the results obtained with W-substituted derivatives, the first of these potentials is attributed to the presence of detectable amounts of the 4-hydroxy-tautomers.
Acceleration of Growth in Two Children Treated with Human Growth Hormone-Releasing Factor (1985)

Two growth hormone-deficient children were treated with growth hormone-releasing factor for six months. The pattern of administration--1 to 3 micrograms per kilogram of body weight, given subcutaneously over one minute every three hours by infusion pump--was chosen to simulate growth hormone secretion in normal children. During the first week of therapy, both children had evidence of the metabolic effects of increased growth hormone secretion--i.e., nitrogen retention, demonstrated by decreased nitrogen excretion (P less than 0.05), and increased urinary calcium excretion (P less than 0.01). Growth hormone secretion was increased after pulses of growth hormone-releasing factor during the entire six-month period, and growth was accelerated. One child grew at a rate of 7.1 cm per year, as compared with 4.6 cm per year before therapy; the other grew at a rate of 13.7 cm per year, as compared with 2.1 cm per year before therapy, and had increased serum levels of somatomedin C. Growth hormone--releasing factor can restore growth hormone secretion and its biologic effects, including an increase in nitrogen retention, an increase in serum somatomedin C, and acceleration of linear growth in children with growth hormone deficiency. It is premature to speculate how useful this agent will prove to be in the treatment of children with growth hormone deficiency.
Calcium carbonate precipitation using new segmented flow tubular reactor (2000)

Abstract A new segmented flow tubular reactor for the continuous production of powders was used to synthesize calcium carbonate by precipitation. This new reactor uses a nonmiscible phase (air in most cases) to create individual microvolumes of the reacting mixture or suspension ensuring that a plug‐flow regime is maintained. In a microvolume, poor micromixing can be avoided and the homogeneity in reaction conditions is increased better than in larger volumes, leading to a better control of powder characteristics. Calcium carbonate with controlled characteristics could be precipitated continuously using this new segmented flow tubular reactor. Pure calcite could be obtained in the tubular reactor by segmenting a Ca 2+ solution with a reactive CO 2 /NH 3 gas mixture. This synthesis process is very promising for industrial production since the scale‐up should easily be achieved by multiplying the number of tubes working in parallel.
Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress (2020)

Prostate cancers (PCs) with loss of the potent tumor suppressors TP53 and RB1 exhibit poor outcomes. TP53 and RB1 also influence cell plasticity and are frequently lost in PCs with neuroendocrine (NE) differentiation. Therapeutic strategies that address these aggressive variant PCs are urgently needed. Using deep genomic profiling of 410 metastatic biopsies, we determine the relationships between combined TP53 and RB1 loss and PC phenotypes. Notably, 40% of TP53/RB1-deficient tumors are classified as AR-active adenocarcinomas, indicating that NE differentiation is not an obligate consequence of TP53/RB1 inactivation. A gene expression signature reflecting TP53/RB1 loss is associated with diminished responses to AR antagonists and reduced survival. These tumors exhibit high proliferation rates and evidence of elevated DNA repair processes. While tumor cells lacking TP53/RB1 are highly resistant to all single-agent therapeutics tested, the combination of PARP and ATR inhibition is found to produce significant responses, reflecting a clinically exploitable vulnerability resulting from replication stress.
Rechtliche Voraussetzungen vor medizinischen Eingriffen bei psychiatrisch behandlungsbedürftigen Patienten (2001)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Familial aggregation of MATRICS Consensus Cognitive Battery scores in a large sample of outpatients with schizophrenia and their unaffected relatives (2017)

In a large sample of stable patients with schizophrenia, living in the community, and in their unaffected relatives, MCCB demonstrated sensitivity to cognitive deficits in both groups. Our findings of significant within-family prediction of MCCB scores might reflect disease-related genetic or environmental factors.
Glow discharge plasma treatment for surface cleaning and modification of metallic biomaterials (1997)

Glow discharge plasma treatment is a frequently used method for cleaning, preparation, and modification of biomaterial and implant surfaces. The merits of such treatments are, however, strongly dependent on the process parameters. In the present work the possibilities, limitations, and risks of plasma treatment for surface preparation of metallic materials are investigated experimentally using titanium as a model system, and also discussed in more general terms. Samples were treated by different low-pressure direct current plasmas and analyzed using Auger electron spectroscopy (AES), x-ray photoelectron spectroscopy (XPS), atomic force microscopy, scanning electron microscopy, and light microscopy. The plasma system is a home-built, ultra-high vacuum-compatible system that allows sample introduction via a load-lock, and precise control of pressure, gas composition and flow rate, etc. This system allows uniform treatment of cylindrical and screw-shaped samples. With appropriate plasma parameters, argon plasma remove all chemical traces from former treatments (adsorbed contaminants and other impurities, and native oxide layers), in effect producing cleaner and more well-controlled surfaces than with conventional preparation methods. Removal (sputtering) rates up to 30 nm/min are possible. However, when inappropriate plasma parameters are used, the result may be increased contamination and formation of unintentional or undesired surface layers (e.g., carbides and nitrides). Plasma-cleaned surfaces provide a clean and reproducible starting condition for further plasma treatments to form well-controlled surface layers. Oxidation in pure O2 (thermally or in oxygen plasmas) results in uniform and stoichiometric TiO2 surface oxide layers of reproducible composition and thicknesses in the range 0.5-150 nm, as revealed by AES and XPS analyses. Titanium nitride layers were prepared by using N2 plasmas. While mild plasma treatments leave the surface microstructure unaffected, heavy plasma treatment can give rise to dramatic morphologic changes. Comparison of these results with corresponding analyses of commercial implants and electropolished and/or anodically oxidized samples shows that the plasma treatment offers superior control of the surface status. However, it is also shown that improper control of the plasma process can produce unwanted and irreproducible results.
Optimal spatial sampling for spherical loudspeaker arrays (2010)

The design of spherical loudspeaker arrays involves the discrete sampling of the sphere. In practical applications the desired number of sample points is very low (possibly 16-32 transducers) and there are typically one or more areas in the room that cannot accommodate loudspeakers. This paper presents an optimization method for choosing loudspeaker locations and driving functions in such a constrained environment. An additional weighting is added to allow for selective optimization of both low spatially-varying components and azimuthal components.
Stereoselective Formation of Quaternary Carbon Centers: Alkylation of α,α‐Disubstituted Amide Enolates. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Crystal Stability and Magnetic Properties of W-type Hexagonal Ferrite Sr1-xBax(ZnLi0.5Fe0.5)Fe16O27. (1996)

Crystal stability and possibility as an anisotropic permanent magnet of W-type hexagonal ferrite with composition of Sr1-xBax [ZnLi0.5Fe0.5]Fe16O27 was investigated. In this study, we found that the amount of Fe2+ in the calcined compound gradually increases with increasing Sr. In the ball-milled compound followed by annealing at 900-1100°C, W phase of Sr[ZnLi0.5Fe0.5]⋅Fe16O27 partially decomposed into M phase and spinel phase. On the other hand, Ba [ZnLi0.5Fe0.5]Fe16O27 remained a single phase. It can be assumed that Fe2+ substituted for (Li+0.5+Fe3+0.5) or Zn2+, and oxidation such as Fe2+→Fe3+ givies rise to decomposition.The grain size of Sr [ZnLi0.5Fe0.5]Fe16O27 and Ba [ZnLi0.5Fe0.5]Fe16O27 sintered at 1175-1225°C, respectively, was 0.3-5.0μm, their coercivity was less than 1000 Oe, and anisotropy energy (KA) and anisotropy field (HA) were estimated with about 60% of those of M-type ferrite. In conclusion, a preparation method of ferrite magnet hgaving more finer grains is necessitated for the practical use.
The Base-Catalyzed Hydrogen-Deuterium Exchange of Nonenolizable Bicyclic Ketones (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Base-Catalyzed Hydrogen-Deuterium Exchange of Nonenolizable Bicyclic KetonesP. G. Gassman and F. V. ZalarCite this: J. Am. Chem. Soc. 1966, 88, 13, 3070–3074Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://pubs.acs.org/doi/10.1021/ja00965a032https://doi.org/10.1021/ja00965a032research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DEPFET Macropixel Detectors for MIXS: First Electrical Qualification Measurements (2010)

The Mercury Imaging X-ray Spectrometer (MIXS) is one of the instruments on board the Mercury Planetary Orbiter of the fifth European Space Agency (ESA) cornerstone mission BepiColombo. This spectrometer comprises two instruments and allows imaging X-ray spectroscopy of the Mercurian surface. The focal plane arrays for the energy and spatial resolved detection of X-rays are based on depleted P-channel FET (DEPFET) macropixel detectors. We report on the first electrical qualification measurements of DEPFET macropixel flight hardware, which are done at room temperature. The measurement of the transistor properties of all DEPFET pixels allows the selection of 100% electrically defect-free devices at an early stage directly after completion of the production process. Additionally, these measurements allow to investigate topics such as the homogeneity of transistor parameters across the detector matrix, to monitor die-to-die variations for matrices from the same wafer, and to investigate the differences between dies from different wafers in order to learn about the stability and reproducibility of the production process. The test results demonstrate good homogeneity and yield for the investigated detector matrices from the first production batch.
Wood densification processing for newly engineered materials (2018)

Wood is a renewable, bio-based material with a mixture of different properties and qualities, used in numerous applications. Beside many species with high wood qualities several species suffer due to a number of disadvantages, where low hardness and abrasive resistance are characteristic for low-density species. This paper presents examples of on-going European research projects and industrial processes mostly related to wood densification methods. Wood densification is a classical thermohydro-mechanical (THM) wood treatment process, through which density is increased by mechanical compression of wood perpendicular to the grain, by impregnation of cell lumens or cell walls with solutions or melted substances (resins, waxes), or by a combination of both. The purpose is to produce newly designed and engineered materials and products with new property profiles, which would potentially find new markets. In general, the THM processes consist of three stages: plasticization of the wood cells, followed by the actualcompression, and finally solidification of the compressed wood in order to prevent elastic spring-back and the moisture-induced set-recovery. The wood densification process refers but is not limited to solid wood and might apply to whole wood pieces, or to local areas within given pieces only. Another THM method is the mechanical compression of wood parallel to the grain, which leads to a product with high flexibility. A European wood research network, represented by the authors of this contribution, has extended experience in many wood modification processes, as demonstrated through ongoing researches and case studies in this paper
Minipig as a model for drug metabolism in man: Comparison of in vitro and in vivo metabolism of propafenone (2003)

To prove the suitability of minipigs as experimental animal in modeling of the drug metabolism and pharmacokine-tics in man, propafenone metabolism in vitro at the microsomal level as well as propafenone pharmacokinetics in the minipig was studied. The results were compared with those obtained for humans. It can be concluded that whereas the microsomal in vitro system of minipig may be a good model for drug metabolism in the man, the pharmacokinetics in the whole organism is more complex reflecting differences in substrate specificities of many enzymatic and transport systems. In this particular case, it has been documented that the glucuronidation of propafenone principal metabolite (5-hydroxypropafenone) is more efficient in the minipig.