gebhart/patrepeval huggingface dataset:
Abstract 5128: Changes in mitochondrial background affect nuclear DNA methylation (2015)

Abstract There is emerging evidence demonstrating that mitochondrial DNA (mtDNA) contributes to complex genetic diseases such as cancer. To test directly the role of mtDNA in tumorigenicity and metastasis, a new genetically engineered mouse model was created that contains nuclear DNA from one mouse strain and mtDNA contribution from different mouse strain(s). Taking advantage of maternal inheritance, Mitochondrial Nuclear Exchange (MNX) mice can be bred to mice sharing the same nuclear DNA background. As a result, MNX serves as an important tool to determine if and how mitochondrial genetic background contributes to cancer, negating the concern for mixing maternal and paternal nuclear DNA polymorphisms. MNX mice are healthy, breed normally, show no overt differences in cell cycle or apoptosis and are genetically stable for multiple (&gt;10) generations. Nonetheless, they are distinct strains based upon behaviors and gene expression patterns. The mechanisms controlling gene expression in different MNX strains are not yet known; however, retrograde and anterograde cross-talk exists between the nuclear and mitochondrial genomes. Our hypothesis is that important epigenetic changes occur in the nuclear genome depending upon mitochondrial genetics. To test this hypothesis, we performed Meth-Seq using the Agilent Mouse SureSelect platform and Affymetrix gene expression arrays on four mouse brains (8 wk) that were pooled from different litters and cages of wild-type and MNX to minimize age, developmental, inter-individual and generational heterogeneity. Both differential DNA methylation and gene expression patterns were observed but analyses are ongoing to better define the observed differences. Together these observations provide novel insights into how mtDNA could be altering epigenetic regulation and thereby contribute to cancer pathogenesis. Support: Susan G. Komen for the Cure (SAC11037), Natl Fndn Cancer Res., Kansas Bioscience Authority, Steiner Family Fund. Citation Format: Carolyn J. Vivian, Amanda E. Brinker, Gerald C. Gooden, Christophe Legendre, Bodour Salhia, Danny R. Welch. Changes in mitochondrial background affect nuclear DNA methylation. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5128. doi:10.1158/1538-7445.AM2015-5128
Excitation of Local Field Enhancement on Silicon Nanowires (2008)

The interaction between light and reduced-dimensionality silicon attracts significant interest due to the possibilities of designing nanoscaled optical devices, highly cost-efficient solar cells, and ultracompact optoelectronic systems that are integrated with standard microelectronic technology. We demonstrate that Si nanowires (SiNWs) possessing metal-nanocluster coatings support a multiplicatively enhanced near-field light-matter interaction. Raman scattering from chemisorbed probing molecules provides a quantitative measure of the strength of this enhanced coupling. An enhancement factor of 2 orders of magnitude larger than that for the surface plasmon resonance alone (without the SiNWs) along with the attractive properties of SiNWs, including synthetic controllability of shape, indicates that these nanostructures may be an attractive and versatile material platform for the design of nanoscaled optical and optoelectronic circuits.
Progress in production-worthy point contact solar cells process (2012)

This work reports on the integration process of rear point contact solar cells with reduced recombination and better light trapping than the conventional cells. Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> passivation stacks were used to ensure the backside passivation and the effective lifetime of minority carrier is found to be >;100 μs (estimated surface recombination velocity ~50 cm/s) on solar p-type Cz wafers. The estimated fixed charge associated with the Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> is in the range of -5e12 C/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Laser ablation of Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> stack and aluminum alloying are studied in detail to understand the process window for clean ablation and back surface field. It is found that laser energy plays an important role cleanly ablating the Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> passivation stack. The solar cell is fabricated using standard processes based on screen-printed aluminum paste onto laser ablated passivation layer consisting of Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> . Aluminum alloying is dependent on the firing profile and amount of Al melted into Si. Back point contact cells show improvements in J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sc</sub> by 1 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> by 10 mV due to better response in infrared spectrum. The best conversion efficiency of back point contact solar cells fabricated with standard industrial emitter and backside passivation is 19.35%.
Activation of human basophils through the IL-8 receptor (1992)

IL-8 and its structural analogs derived from blood platelets have been proposed as stimuli of IgE-independent basophil activation. In order to clarify the mechanism of action of these peptides, we examined the effects of pure IL-8, connective tissue-activating peptide III (CTAP-III), neutrophil-activating peptide 2 (NAP-2), and platelet factor 4 (PF-4) on blood basophils with and without pretreatment by IL-3, which modulates mediator release. After pretreatment with IL-3, significant histamine release was observed with 10(-8) M and 10(-7) M IL-8 and 10(-7) M NAP-2, but not with the other peptides. At higher concentrations (10(-6) M), however, all IL-8 analogs, as well as the unrelated cationic peptides poly-D-lysine, histone VS, and lysozyme, induced histamine release to variable degrees. Binding and competition studies with [125I]IL-8 revealed specific IL-8R on basophils from a patient with chronic myelogenous leukemia and normal individuals. From 3500 to 9600 receptors with a mean Kd value of 0.15 nM were found on average per chronic myelogenous leukemia and normal basophil, respectively. NAP-2 weakly competed for IL-8 binding. IL-8 and, to a lesser extent, NAP-2 led to a transient rise of cytosolic free calcium concentration ([Ca2+]i), which was independent of a preexposure to IL-3. IL-8 prevented the [Ca2+]i rise induced by NAP-2, but did not influence [Ca2+]i responses to other agonists, e.g. C5a, C3a, or platelet-activating factor. IL-8 induced [Ca2+]i changes and histamine release in IL-3-primed basophils were pertussis toxin sensitive. CTAP-III or PF-4 did not compete for IL-8 binding, did not induce [Ca2+]i changes, and did not influence the [Ca2+]i response to IL-8 and NAP-2. This study shows that IL-8 and NAP-2 activate human basophils by a receptor-mediated mechanism similar to that operating in neutrophils. At high concentrations histamine release can also be induced by cationic peptides by a mechanism that does not involve the IL-8R, and probably depends on cationic interactions.
Improving the accuracy of speech emotion recognition using acoustic landmarks and Teager energy operator features (2015)

Affective computing can help us achieve more intelligent user interfaces by adding the ability to recognize users’ emotions. Human speech contains information about the emotional state of the speaker and can be used in emotion recognition systems. In this paper, we present a machine learning approach using acoustic features which improves the accuracy of speech emotion recognition. We used 698 speech samples from ”Emotional Prosody Speech and transcripts” corpus to train and test the classifiers. The emotions used were happy, sadness, hot anger, panic, and neutral. Mel-frequency Cepstral Coefficients (MFCC), Teager Energy Operator (TEO) features, and acoustic landmark features were extracted from speech samples. Models were trained using multinomial logistic regression, k-Nearest Neighbors(k-NN) and Support Vector Machine(SVM) classifiers. The results show that adding landmark and TEO features to MFCC features improves the accuracy of classification. SVM classifiers with a Gaussian kernel had the best performance with an average accuracy of 90.43%. We achieved significant improvement in the accuracy of the classification compared to a previous study using the same dataset.
Initial Operation Of A Polarization-Controlled Beamed ECH Launcher (1988)

A system for launching 53.2-GHz electron cyclotron heating (ECH) power is being installed on the Advanced Toroidal Facility (ATF) fusion experiment at Oak Ridge National Laboratory. The launcher provides a narrow linearly polarized beam. The plane of polarization is easily rotated. Measurements indicate that the launcher will have a -20 dB beam width of 15 cm at the plasma center and polarization purity of >97%. The ATF (1) requires 53.2-GHz microwave power for ECH plasma ionization and heating; this power is generated by a 200-kW cw gyrotron. Theoretical ray tracing studies have shown almost complete first-pass power absorption is possible if the power is within the saddle point in the proper polarization (2). Therefore, a narrow-beam-width launcher with adjustable polarization is being developed. In ATF the confining magnetic field can operate continuously at 1 T or in long pulses at 2 T. Either second harmonic or fundamental ECH absorption occurs, depending on the field strength, and it is of interest to operate experiments using both values. With perpendicular propagation and low-field-side launch, the ECH power must be in the extraordinary mode (X-mode, Erf perpendicular to Bo) for second harmonic (co = 2 wee) or in the ordinary mode (0-mode, Enr parallel to Bo) for fundamental (o) = c),) operation. The magnetic field in ATF is formed primarily by helical windings, which produce a shear in the plane of the field along a radial chord. This shear may cause polarization rotation of the ECH wave as it travels through the outer plasma regions because of the unequal 0- and X-mode phase velocities at higher plasma density (similar to Faraday rotation). The ECH resonance zone is a 10-cm-wide saddle point near the plasma center.
Fracture and crack growth in orthotropic laminates (1985)

A mathematical model based on the classical shear-lag assumptions is used to study the residual strength and fracture behavior of composite laminates with symmetrically placed buffer strips. The laminate is loaded by a uniform remote longitudinal tensile strain and has initial damage in the form of a transverse crack in the parent laminate between buffer strips. The crack growth behavior as a function of material properties, number of buffer-strip plies, spacing, width of buffer strips, longitudinal matrix splitting, and debonding at the interface is studied. Buffer-strip laminates are shown to arrest fracture and increase the residual strengths significantly over those of one material laminates, with S-glass being a more effective buffer strip material than Kevlar in increasing the damage tolerance of graphite/epoxy panels. For a typical graphite/epoxy laminate with S-glass buffer-strips, the residual strength is about 2.4 times the residual strength of an all graphite/epoxy panel with the same crack length. Approximately 50% of this increase is due to the S-glass/epoxy buffer-strips, 40% due to longitudinal splitting of the buffer strip interface and 10% due to bonding.
Design of vertical air classifiers for municipal solid waste (1987)

Abstract A previously published diffusion‐based mathematical model is used to simulate data from two vertical air classifiers operating on shredded municipal solid waste streams. Good agreement with the model is achieved at high values of the air/solids ratio, that is, the region where interaction between solid particles would be expected to be insignificant. At lower values of the air/solids ratio the concept of a recovery efficiency is introduced to take account of interaction effects. This efficiency appears to show the expected dependence on air/solids ratio. A design method is proposed, based on feed particle size distribution and relationships between recoveries and product qualities.
New lower bound techniques for robot motion planning problems (1987)

We present new techniques for establishing lower bounds in robot motion planning problems. Our scheme is based on path encoding and uses homotopy equivalence classes of paths to encode state. We first apply the method to the shortest path problem in 3 dimensions. The problem is to find the shortest path under an Lp metric (e.g. a euclidean metric) between two points amid polyhedral obstacles. Although this problem has been extensively studied, there were no previously known lower bounds. We show that there may be exponentially many shortest path classes in single-source multiple-destination problems, and that the single-source single-destination problem is NP-hard. We use a similar proof technique to show that two dimensional dynamic motion planning with bounded velocity is NP-hard. Finally we extend the technique to compliant motion planning with uncertainty in control. Specifically, we consider a point in 3 dimensions which is commanded to move in a straight line, but whose actual motion may differ from the commanded motion, possibly involving sliding against obstacles. Given that the point initially lies in some start region, the problem of finding a sequence of commanded velocities which is guaranteed to move the point to the goal is shown to be non-deterministic exponential time hard, making it the first provably intractable problem in robotics.
A CASE OF GLUCOCORTICOID RESPONSIVE ALDOSTERONISM (1981)

45才の主婦で, 13年前より高血圧を指摘され, 3年前より降圧薬の投与を受けている.理学的には皮膚色素沈着,性徴の異常はなく,血圧は202/104mmHgで,検査所見では低K血症を認め,腎機能は正常であつた. Kクリアランスは正常で,全身K量は1.26g/kgと異常低値であつた.血漿レニン活性の基礎値は0.04ng/ml/hと異常低値で,刺激試験に対して反応はなかつた.血漿アルドステロンは基礎値は218pg/mlと異常高値で,低Na食3日間と立位4時間により325pg/mlまで上昇した.循環血漿量や尿中カテコラミン排泄値は正常であつた. 17-OH-progesterone起源のC21ステロイド, 17-OH progesterone起源のC19ステロイドは正常であつた.また血漿プロゲステロン,血漿ACTHは正常であつた.副腎静脈造影,副腎静脈血アルドステロン,副腎シンチグラムなどでは腺腫の存在は否定的で,血漿アルドステロンはACTHの投与により著増した.デキサメサゾン1日2mgを28日間投与することにより,血圧は190/110mmHgから138/80mmHgへ下降し,血清Kは3.6mEq/lから3.8mEq/lへ変化し,血漿アルドステロンは198pg/mlから30pg/mlへ低下した.また血漿コーチゾール,血漿ACTHの日内変動は消失した.原発性アルドステロン症の手術療法を考慮する際には,デキサメサゾン投与試験を行ない,糖質コルチコイド反応性アルドステロン症との鑑別が重要であると考えられる.
AE391 and AF291 antibodies recognize an HA-tagged recombinant protein by immunofluorescence (2020)

AE391 and AF291 antibodies against the HA tag recognize an HA-tagged human TAC protein by immunofluorescence in paraformaldehyde-fixed HeLa cells.
Artefacts in MR images of electrical current distribution (1997)

Artefacts in images of electrical current distribution measured by magnetic resonance imaging (MRI) are presented. These artefacts, caused by the effects of the connecting cables used to apply the electrical current to the object during the MRI scan, can lead to an underestimation of the magnitude of the electrical current measured in the experiment. The size of this underestimate depends upon the experimental geometry, but in the experiments and simulations described here, performed with a cylindrical phantom approximately 8 cm long and 8 cm in diameter, the difference can be 27%. These artefacts are reduced if the connecting cables are rigidly fixed to the object so that the induced magnetic field is correctly measured during the MRI experiment.
An overview of 60 GHz location systems operating in multipath environments (2011)

This study deals with a non-exhaustive overview of location systems operating in the 60 GHz frequency band. Both impulse and frequency hopping topologies are considered and the performances of the two realized systems are presented. For each system, a specific signal processing has been implemented to prevent the degradation of the location error from the impact of the multipath propagation.
Amine-Functionalized Periodic Mesoporous Organosilicas (2001)

Ordered mesoporous materials have been synthesized by co-condensation of bis(triethoxysilyl)ethane and N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AAPTS) under basic conditions with supramolecular templates of cetyltrimethylammonium chloride as structure-directing agents. Incorporation of the templates into the mesoscopic composite was followed by surfactant extraction to form periodic mesoporous organosilicas. These materials have been characterized by powder X-ray diffraction, nitrogen gas sorption, metal ion adsorption, elemental analysis, and high resolution thermogravimetric analysis. The effects of AAPTS concentration in the initial solutions on the chemical and structural properties of the final products are examined.
Transtelephonic Monitoring in Pediatric Patients with Clinically Suspected Arrhythmias (1984)

Evaluation of patients with symptoms suggestive of cardiac arrhythmias is difficult using standard studies if the episodes are infrequent and have a short duration. Transtelephonic electrocardiographic recorders were provided for 41 patients with suspected arrhythmic episodes. None had previously documented arrhythmia. There were 18 males and 23 females (age range 14 months to 19 years; mean 10.9 years). The interval prior to a diagnostic transmission was 0.5 to 8 months (mean 2.5 months). Twenty-one of 41 patients (51%) provided transmissions during a typical episode, nine of which were abnormal. Paroxysmal supraventricular tachycardia was found in eight patients and unsuspected intermittent complete heart block in one patient. The remaining 12 patients had normal sinus rhythm. Twenty patients did not transmit because episodes either were too brief or did not recur. Transtelephonic monitoring was effective in the diagnosis of certain arrhythmias that are infrequent and short in duration. Normal transmitted electrocardiograms during a typical symptomatic episode excluded cardiac arrhythmias.
Asymmetrische elektrophile α‐Amidoalkylierung, 4. Mitt.: Erzeugung und Abfangreaktionen chiraler N‐Acylpyrrolidiniumionen (1989)

Abstract Die Pyrrolderivate 1 , 6 und 10 werden unter TiCl 4 ‐Katalyse stereoselektiv mil dem Silylenolether 3 zu 2‐substituierten Pyrrolidinamiden umgesetzt. 6 sowie 10 (nach HCl‐Addition = > 11 ) sind noch bei −78°C reaktiv, wobei die Reaktion von 10 die von 6 in Ausbeute und Stereoselektivität übertrifft.
[Platelets and liver regeneration]. (2012)

Platelets contain growth factors and cytokines such as hepatocyte growth factor, tumor necrosis factor-α, interleukin-6, serotonin, insulin-growth factor-1, transforming growth factor-α, endothelial growth factor, sphingosine 1-phosphate, etc. Platelets are activated by various types of stimulation and release these physiologically active substances depending on each context. In addition to primary roles as hemostasis and thrombosis, recent studies have reported the roles of platelets on promoting liver regeneration, improving liver fibrosis, and attenuating liver damage. In this article, we reviewed the recent advances in knowledge of the role of platelets in accelerating liver regeneration.
Abstract 16528: Predictive and Protective Value of High Density Lipoprotein-Cholesterol for Cardiovascular Events in Patients With Acute Myocardial Infarction Who had Percutaneous Coronary Intervention and Statin Treatment (2014)

Introduction: Low level of high density lipoprotein-cholesterol (HDL-C) has been identified as a residual risk of cardiovascular events after lowering low density lipoprotein-cholesterol (LDL-C) in patients with stable coronary artery disease. Further, high HDL-C level is proven to have a protective effect for cardiovascular events in primary prevention studies. Hypothesis: We assessed the hypothesis that we evaluated whether the HDL-C level may have predictive and protective value in patients with acute myocardial infarction (MI) who had percutaneous coronary intervention (PCI) and statin treatment. Methods: A total of 15,938 patients who had PCI and statin treatment were selected from the Korean Myocardial Infarction registry. According to the ATP III criteria, baseline HDL-C level was used to identify patients with low HDL-C (<40 mg/dL, Group A), normal HDL-C (≥40 to < 60 mg/dL, Group B), or high HDL-C (≥60 mg/dL, Group C). Major adverse cardiac events (MACE) at one-year, the primary endpoint, were com...
Selective Deposition of Metal Complex Nanocrystals onto the Surfaces of Organic Single Crystals Bearing Pyridine Moieties (2009)

Nanocrystals of a palladium complex 3 were deposited onto the specific surfaces of the single crystals of CT complex (CT1) between pyrene and naphthyldiimide bearing pyridine groups. They were characterized by X-ray powder diffraction (XRD) and scanning electron microscope equipped with energy-dispersive X-ray spectroscopy (SEM-EDX). Nanocrystals of 3 were deposited selectively onto {011̅} faces. Comparison between the crystal structures and deposition preference of the crystal faces revealed that deposition of 3 occurred on the most hydrophobic face of the single crystals of CT1 that exposed no pyridine moieties. This indicated that accessibility or coordination of metal complexes to the pyridine moieties apparently suppressed deposition of the nanocrystals. As a result, the nanocrystals were easily deposited onto the hydrophobic crystal surfaces, and rapid growth provides the thin-film decoration of the selective crystal faces.
Imprinted Polymer Inverse Opals for the Detection of Nanoparticles (2019)

Because of their small size, nanoparticles present specific properties and are extensively present in our everyday life. They are used in many industrial fields (paintings, cosmetics, food industry). Toxicity and especially eco-toxicity of these particles are not well-known yet and further data on their impact on human health and on the environment are absolutely needed. Nevertheless, effects such as airway inflammation or disruption of neuronal functions have been established by experiments on animals. Consequently, the development of sensitive devices for measuring exposure to nanoparticles with selective recognition and size measurement is absolutely needed.
Pyridyl-cyclodextrin for ultra-hydrosolubilization of [60]fullerene (2014)

An efficient hydrosolubilizing reagent for [60]fullerene (C60) was newly developed with a γ-cyclodextrin (γ-CD) derivative having triazole-methoxypyridyl moieties at its 6-hydroxyl positions (PCD). Through solid-state mechanochemical complexation, PCD forms a hydrosoluble inclusion complex of C60 with a concentration of more than 70 mM. This is approximately 90 times greater than that with non-substituted γ-CD prepared by the same method.