gebhart/patrepeval huggingface dataset:
Antibacterial diterpenes from the leaves and seeds of <i>Juniperus excelsa</i> M. Bieb (1992)

Abstract Two diterpenes from Juniperus excelsa , obtained by bioautography‐guided isolation technique, were found to possess significant antibacterial activity in a two‐fold serial dilution assay. (+)‐Ferruginol (abieta‐8,11,13‐triene‐12‐ol) (1) and (−)‐sandaracopimeric acid (isopimara‐8(14), 15‐diene‐18‐oic acid) (2) exhibited significant activity against Bacillus subtilis, Staphylococcus aureus and Streptococcus durans , while their corresponding 3β‐hydroxy derivatives [(hinokiol (3) and 3β‐hydroxysandaracopimeric acid (4), also isolated from J. excelsa )] were found to be inactive. (+)‐Ferruginol, in addition, demonstrated strong activity against Mycobacterium smegmatis, M. intracellulare, M. xenopi and M. cheloni. The minimum inhibitory concentrations were determined for all compounds isolated from the active bioautographic zones, and were compared to those of the standard antibiotics chloramphenicol and streptomycin sulphate.
α‐Alkylation of Ketones by Addition of Zinc Enamides to Unactivated Olefins. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
S.H.A.R.P: A smart Hierarchical Algorithm to Register Psoriasis (2004)

* To the SITE Project funded by a grant from the Danish Technical Research Foundation (Project Number STVF 56-00-0123. Abstract – A In this work, an automatic algorithm for registering psoriasis images is proposed. The algorithm, made up of two stages, takes advantage of the behaviour of the disease. In the first stage, the diseased area is segmented in the image. The second stage uses this information to align the image based on the two first statistical moments of the area. The algorithm is compared with other existing methods. One of these methods was developed specifically to register psoriasis images. Results show the suitability of the proposed algorithm from the point of view of accuracy, parameter dependency and speed.
Cavity-resonator-integrated guided-mode resonance filter in channel waveguide (2013)

A cavity-resonator-integrated guided-mode resonance filter (CRIGF) consisting of a grating coupler and a pair of distributed Bragg reflectors in a channel waveguide is proposed for a narrow-band reflection spectrum with a small aperture. A channel waveguide structure and grating pattern of the device were simultaneously formed by the electron-beam direct-writing lithography. A full-width at half-maximum of reflection spectrum of the fabricated CRIGF was about 0.3nm with the maximum reflectance of about 30%. A reflection phase varied by almost 2π for wavelength change of 1nm.
Frameworks for precise program analysis (2001)

Program analysis has become more frequently used for applications such as automatic parallelization, debugging, and program comprehension. These new applications require new methods that provide greater precision at lower computational cost than traditional techniques developed for program analysis in compilers. However, these new methods incur new costs in complexity of understanding and use. To facilitate their use we need sound frameworks which support the construction of analyses based upon them, allowing reuse without constant reinvention for each application. 
In the exploration of three difficult program analysis problems, we resolved a number of issues involved in their solution, and developed three frameworks which can help in the future to ease the task of constructing analyses to solve related problems. Some of our frameworks have already been generalized and applied to other analyses beyond those for which they were originally designed. 
Automatic parallelizers are an important tool for shared-memory multiprocessors, as they enable sequential code to realize improved performance without extra programmer effort. The SUIF automatic parallelizer proved highly effective on scientific applications. Essential to its success was a new framework for interprocedural analysis which facilitated construction of the many analyses involved in parallelization. The technique of region-based analysis with selective cloning it incorporated allows precise interprocedural analysis results at low cost. 
Parallelizer results can be improved by a more systematic treatment of predicates in the program. A general framework for a predicated data-flow analysis provides this treatment, by associating predicates with data-flow values in any analysis. A predicated data-flow analysis can approximate a feasible path analysis, or derive guards for conditionally parallel loops. Several issues prove critical: sound treatment of approximation, avoiding an explosion of predicates with scoping and normalization mechanisms, and reducing analysis costs through a sparse formulation. 
The technique of analysis with partial transfer functions makes it possible to build precise and efficient interprocedural analyses for languages with recursion and higher-order functions, but it is underutilized due to its complexity and inscrutability. We develop a foundational framework for exploiting this promising technique to facilitate more efficient interprocedural analyses. This development should serve as a foundation for continuing work.
Immunological and histological studies in primary biliary cirrhosis (1970)

Thirty-one patients with primary biliary cirrhosis in whom adequate histological liver material was available were studied by immunological and histological methods. There was no statistically significant correlation between individual histological features and the level of serum mitochondrial antibodies. A relationship between the duration of symptoms and histological stage of the disease supports the present concept of its evolution. However, several stages were often identified in the same specimen. Four cases with negative mitochondrial antibodies were similar to the other 27 clinically and histologically.
CONTROL MECHANISMS IN HEMOGLOBIN SYNTHESIS (1964)

Division of Biochemistry, Department of Biology, Massachusetts Institute of Technology, Cambridge, Mass. * This work was supported by grants from the National Science Foundation (G-20379) and the U.S. Public Health Service (AM-03409).
An Investigation of the Steady-State Performance of a Wave Aerodynamic Thrust Bearing for High Speed Applications (2012)

The steady-state performance of an aerodynamic double thrust wave bearing was investigated. The investigation showed that a double thrust wave bearing with an inner diameter of 15 mm and an outer diameter of 45 mm can support axial loads of 200 N at 100,000 rpm for a minimum film thickness of 3 microns. The influence of the wave bearing parameters on the bearing performance was also analyzed. The theoretical analysis was validated by experimentally testing one side of the thrust bearing. A special test rig was built for this purpose. The experimental data were close to the numerical predictions, validating the computer codes.
The influence of seasonal vertical temperature gradients on no‐purge sampling of wells (2012)

Abstract Seasonal changes in ambient temperature create vertical temperature gradients in shallow groundwater (less than 15 m). These temperature gradients can affect in‐well flow dynamics that impact samples collected using no‐purge sampling methods. In late winter, the shallower water is colder, resulting in thermally mixed conditions and uniform contaminant concentrations. In late summer, the shallower water is warmer, resulting in thermally stratified conditions and contaminant distributions in the monitoring well more consistent with the distribution in the surrounding aquifer. The importance of seasonal temperature gradients on in‐well mixing was evaluated in two shallow monitoring wells in Houston, Texas. In each of the two wells, four vertically spaced passive diffusion samples collected in late winter showed a less than 1.3x difference in trichloroethene (TCE) concentration between depths, while the same sampling conducted in late summer showed greater than a 100x difference in TCE concentration between depths. A simple analytical model originally developed to predict vertical soil temperature profiles can also be used to predict the occurrence of thermally stratified and thermally mixed conditions in monitoring wells as a function of time and well depth. The results of this analysis and modeling suggest that shallow monitoring wells in most of the United States and Canada can have significantly different vertical concentration profiles within the well over the course of a year due to seasonal vertical temperature gradients. This can induce additional intra‐annual temporal variability on passive no‐purge sampling results from these shallow wells, potentially making it more difficult to discern true trends in the data. © 2012 Wiley Periodicals, Inc.
Demonstration of latency reduction in electrical interconnections using optical fanout (2006)

We present a hybrid opto-electronic system capable of improving the performance of on-chip electrical fanout architectures. Our opto-electronic system employs a layer of optical fanout and utilizes the electrical isolation between the receiving nodes. Through our proof-of-concept links, we show a 15% latency reduction for links as short as 200mum and 50% reduction at 2mm
De Novo Donor-Specific HLA Antibodies Are Associated With Rapid Loss of Graft Function Following Islet Transplantation in Type 1 Diabetes (2015)

Outcomes after islet transplantation continue to improve but etiology of graft failure remains unclear. De novo donor-specific human leukocyte antigen (HLA) antibodies (DSA) posttransplant are increasingly recognized as a negative prognostic marker. Specific temporal associations between DSA and graft function remain undefined particularly in programs undertaking multiple sequential transplants. Impact of de novo DSA on graft function over 12 months following first islet transplant was determined prospectively in consecutive recipients taking tacrolimus/mycophenolate immunosuppression at a single center. Mixed-meal tolerance test was undertaken in parallel with HLA antibody assessment pretransplant and 1–3 months posttransplant. Sixteen participants received a total of 26 islet transplants. Five (19%) grafts were associated with de novo DSA. Five (31%) recipients were affected: three post–first transplant; two post–second transplant. DSA developed within 4 weeks of all sensitizing grafts and were associated with decreased stimulated C-peptide (median [interquartile range]) at 3 months posttransplant (DSA negative: 613(300–1090); DSA positive 106(34–235) pmol/L [p = 0.004]). De novo DSA directed against most recent islet transplant were absolutely associated with loss of graft function despite maintained immunosuppression at 12 months in the absence of a rescue nonsensitizing transplant. Alemtuzumab induction immunosuppression was associated with reduced incidence of de novo DSA formation (p = 0.03). Outcomes after islet transplantation continue to improve but etiology of graft failure remains unclear. De novo donor-specific human leukocyte antigen (HLA) antibodies (DSA) posttransplant are increasingly recognized as a negative prognostic marker. Specific temporal associations between DSA and graft function remain undefined particularly in programs undertaking multiple sequential transplants. Impact of de novo DSA on graft function over 12 months following first islet transplant was determined prospectively in consecutive recipients taking tacrolimus/mycophenolate immunosuppression at a single center. Mixed-meal tolerance test was undertaken in parallel with HLA antibody assessment pretransplant and 1–3 months posttransplant. Sixteen participants received a total of 26 islet transplants. Five (19%) grafts were associated with de novo DSA. Five (31%) recipients were affected: three post–first transplant; two post–second transplant. DSA developed within 4 weeks of all sensitizing grafts and were associated with decreased stimulated C-peptide (median [interquartile range]) at 3 months posttransplant (DSA negative: 613(300–1090); DSA positive 106(34–235) pmol/L [p = 0.004]). De novo DSA directed against most recent islet transplant were absolutely associated with loss of graft function despite maintained immunosuppression at 12 months in the absence of a rescue nonsensitizing transplant. Alemtuzumab induction immunosuppression was associated with reduced incidence of de novo DSA formation (p = 0.03).
Structure analysis of the two-peptide bacteriocin lactococcin G by introducing d-amino acid residues (2010)

The importance of 3D structuring in the N- and C-terminal ends of the two peptides (39-mer LcnG-alpha and 35-mer LcnG-beta) that constitute the two-peptide bacteriocin lactococcin G was analysed by replacing residues in the end regions with the corresponding D-isomeric residues. When assayed for antibacterial activity in combination with the complementary wild-type peptide, LcnG-alpha with four D-residues in its C-terminal region and LcnG-beta with four d-residues in either its N- or its C-terminal region were relatively active (two- to 20-fold reduction in activity). 3D structuring of the C-terminal region in LcnG-alpha and the C- and N-terminal regions in LcnG-beta is thus not particularly critical for retaining antibacterial activity, indicating that the 3D structure of these regions is not vital for interpeptide interactions or for interactions between the peptides and cellular components. The 3D structure of the N-terminal region in LcnG-alpha may be more important, as LcnG-alpha with four N-terminal D-residues was the least active of these four peptides (10- to 100-fold reduction in activity). The results are consistent with a proposed structural model of lactococcin G in which LcnG-alpha and -beta form a transmembrane parallel helix-helix structure involving approximately 20 residues in each peptide, starting near the N terminus of LcnG-alpha and at about residue 13 in LcnG-beta. Upon expressing the lactococcin G immunity protein, sensitive target cells became resistant to all of these D-residue-containing peptides. The end regions of the two lactococcin G peptides are consequently not involved in essential structure-dependent interactions with the immunity protein. The relatively high activity of most of the D-residue-containing peptides suggests that bacteriocins with increased resistance to exopeptidases may be generated by replacing their N- and C-terminal residues with d-residues.
Pattern recognition-a technique for induction machines rotor broken bar detection (2003)

A pattern recognition technique based on Bayes minimum error classifier is developed to detect broken rotor bar faults in induction motors at the steady state. The proposed algorithm uses only stator currents as input without the need for any other variables. First, rotor speed is estimated from the stator currents, then appropriate features are extracted. The produced feature vector is normalized and fed to the trained classifier to see if the motor is healthy or has broken bar faults. Only the number of poles and rotor slots are needed as pre-knowledge information. A theoretical approach together with experimental results derived from a 3 HP AC induction motor show the strength of the proposed method. In order to cover many different motor load conditions data are obtained from 10% to 130% of the rated load for both a healthy induction motor and an induction motor with a rotor having 4 broken bars.
Maternal-fetal pharmacokinetics of methanol. (Includes the commentary of the Institute`s Health Review Committee). Research report (1996)

This study defines the physiological factors that govern methanol delivery to the developing fetus after maternal methanol exposure. The disposition of methanol after oral or intravenous administration was similar in pregnant and nonpregnant rats, regardless of the gestational stage (day 7, 14, or 20 after conception) at which the toxicokinetics of methanol were observed. Parallel experiments in female mice indicated that methanol elimination was approximately twice as rapid in mice due to a significantly higher maximal velocity of methanol metabolism in this smaller rodent species. During inhalation exposure in the rat, methanol absorption was mediated entirely by the nose, and absorption decreased with increasing exposure concentration. Methanol absorption from the airstream was significantly higher in the mouse than in the rat. Apparently due to these species differences in absorption during inhalation, blood methanol concentrations were two- to threefold higher in the mouse than in the rat despite the approximately twofold more rapid elimination of methanol in the mouse. Methanol elimination from the systemic circulation was nonlinear due to saturation of the metabolic pathways for the breakdown of methanol. In addition, a significant parallel linear route of methanol elimination was observed, which accounted for an increasingly significant fraction of methanol eliminationmore » as exposure or systemic concentrations increased. Using the results of this study, a toxicokinetic model based on physiologic measurements was constructed that describes methanol disposition in rats and mice during pregnancy.« less
Reaction Mechanism and Allosteric Regulation of Class Ia Ribonucleotide Reductase from Escherichia coli (2004)

Ribonculeotide reductase (RNR) plays a key role in catalysing a reaction that provides all living organisms with building blocks for DNA. The RNR enzyme catalyses the conversion of ribonucleotides to their corresponding deoxyribonucleotides, by using free radical chemistry. The class Ia enzyme from Escherichia coli is composed of two components, R1 and R2 proteins. Both components are required for the catalytic reaction. The R2 protein contains a stable tyrosyl free radical, which is directly involved in the catalysis. The R1 protein, contains the active site and two different allosteric sites, which are responsible for regulating the enzyme activity and its substrate specificity.An evolutionary conserved active site residue, Asn437, was studied. Employing site directed mutagensis it was shown that the Asn437 is essential for the catalytic reaction. Also using biophysical methods, it was shown that the Asn437 residue participates in the later part of the catalytic reaction.By using protein engineering, two conserved overall activity residues His59 and His88 were shown to be involved in the allosteric regulation of enzymatic activity. Furthermore, it was shown by biosensor technique (BIAcore) that the His59 and His88 participate in a communication network that regulates the binding affinity between the R1 and R2 components in response to the presence of certain allosteric effectors.The influence of the allosteric effectors and substrate nucleotides on the wild type R1/R2 interaction was investigated using biosensor technique. The presence of allosteric effectors strengthened the affinity between the components R1 and R2 as compared to the affinity in the absence of effectors. Interestingly, when both allosteric effectors and substrate nucleotides were present, the affinity between the R1 and R2 components was noticeably stronger as compared to the situations where only the allosteric effector was present.Finally, the residues located in the interaction area of the dimeric R1 protein from E. coli were studied. The aim was to understand their importance for the formation of the active dimeric form of R1. Interestingly, slight alterations of the chemical properties of single side chains resulted in drastic changes in dimer stability, indicating the importance of their interaction ability for dimer formation.
Airborne gravity and magnetics interpretation of the Putumayo and Upper Magdalena Valley, Colombia (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Airborne gravity and magnetics interpretation of the Putumayo and Upper Magdalena Valley, ColombiaAuthors: J. CeronT. R. HorscroftJ. E. BainJ. CeronEcopetrol, T. R. HorscroftGeco‐Prakla, and J. E. BainLCThttps://doi.org/10.1190/1.1886107 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1886107FiguresReferencesRelatedDetailsCited By6. Gravity Exploration MethodsM. N. Nabighian, M. E. Ander, V. J. S. Grauch, R. O. Hansen, T. R. LaFehr, Y. Li, W. C. Pearson, J. W. Peirce, J. D. Phillips, and M. E. Ruder21 March 2012Historical development of the gravity method in explorationGEOPHYSICS, Vol. 70, No. 6 SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION J. Ceron, T. R. Horscroft, and J. E. Bain, (1997), "Airborne gravity and magnetics interpretation of the Putumayo and Upper Magdalena Valley, Colombia," SEG Technical Program Expanded Abstracts : 707-709. https://doi.org/10.1190/1.1886107 Plain-Language Summary PDF DownloadLoading ...
OpWise: Operons aid the identification of differentially expressed genes in bacterial \nmicroarray experiments (2005)

Background-Differentially expressed genes are typically identified by analyzing the variation between replicate measurements. These procedures implicitly assume that there are no systematic errors in the data even though several sources of systematic error are known. Results-OpWise estimates the amount of systematic error in bacterial microarray data by assuming that genes in the same operon have matching expression patterns. OpWise then performs a Bayesian analysis of a linear model to estimate significance. In simulations, OpWise corrects for systematic error and is robust to deviations from its assumptions. In several bacterial data sets, significant amounts of systematic error are present, and replicate-based approaches overstate the confidence of the changers dramatically, while OpWise does not. Finally, OpWise can identify additional changers by assigning genes higher confidence if they are consistent with other genes in the same operon. Conclusioni-Although microarray data can conta in large amounts of systematic error, operons provide an external standard and allow for reasonable estimates of significance. OpWise is available at http://microbesonline.org/OpWise.