gebhart/patrepeval huggingface dataset:
New endotracheal tube adaptor reducing cardiopulmonary effects of suctioning (1979)

The continuous recordings of arterial oxygen saturation (SaO2) and beat-to-beat heart rate before, during, and after tracheobronchial suctioning were studied in eight preterm infants with severe RDS receiving mechanical ventilation. Two suctioning procedures were alternatively performed in each infant; In procedure A, disconnection of the ventilator and preoxygenation preceded suctioning; in procedure B, a special suction adaptor was used without ventilatory interruption or preoxygenation; 128 suctionings were performed with each procedure and the changes in heart rate (HR) and SaO2 during suctioning were compared. Although in both procedures, HR and SaO2 decreased during suctioning, the degree of bradycardia and arterial blood oxygen desaturation were significantly smaller in magnitude and shorter in duration during procedure B. These data indicate advantages of the suction adaptor in minimizing bradycardia and hypoxia from airway suction.
Vacuum-Assisted Microwave Processing of Animal Tissues for Electron Microscopy (2001)

Microwave (MW) technology has found a permanent niche in the world of surgical pathology, biomedical research, and allied disciplines, for a few simple reasons: It can reduce the processing times for tissue samples destined for evaluation by light, scanning, or electron microscopy (EM); it is relatively inexpensive; and it is applicable to a wide range of applications that extend beyond tissue processing. MW-assisted processing of tissue samples, sections, or slides is a new tool in the way the art and science of tissue processing is approached. Understanding of the technology and how to apply it are probably the two most critical factors in determining overall individual success or failure. This report may provide a better understanding of the methods of MW-assisted processing, and introduce a new methodology for tissues being processed for evaluation by EM.
Montmorillonite Clay Catalyzed Hetero‐Diels—Alder Reaction of 2,3‐Dimethyl‐1,3‐butadiene with Benzaldehydes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020)

Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases and extend healthspan. The use of Bcl-xl inhibitors as senolytics is largely limited by their on-target and dose-limiting platelet toxicity. Here, we report the use of proteolysis-targeting chimera (PROTAC) technology to reduce the platelet toxicity of navitoclax (also known as ABT263), a Bcl-2 and Bcl-xl dual inhibitor, by converting it into PZ15227 (PZ), a Bcl-xl PROTAC, which targets Bcl-xl to the cereblon (CRBN) E3 ligase for degradation. Compared to ABT263, PZ is less toxic to platelets, but equally or slightly more potent against SCs because CRBN is poorly expressed in platelets. PZ effectively clears SCs and rejuvenates tissue stem and progenitor cells in naturally aged mice without causing severe thrombocytopenia. With further improvement, Bcl-xl PROTACs have the potential to become safer and more potent senolytic agents than Bcl-xl inhibitors.
Mortality Rates Among Workers Exposed to Dioxins in the Manufacture of Pentachlorophenol (2009)

Other than possibly an increased risk of non-Hodgkin lymphoma, we find no other cause of death related to the mixture of the dioxin contaminants found in PCP.
Functional domains of the human C1q A-chain. (1993)

This brief review was inspired by discussions relating to the IIIrd. International C1 Workshop (this volume) and the realization that certain functional properties of the C1q molecule are limited exclusively to the A-chain. The collagen-like region of the A-chain contains a major binding site for non-immunoglobulin substances, which include C-reactive protein, serum amyloid P, LPS and DNA. This binding site is immediately adjacent to, and partially overlapping with, an arthritis-modulating epitope common to the C1q A-chain and various types of collagen, including cartilage type II collagen. At the N-terminal end of the C1q A-chain is a leader peptide sequence that anchors the intact C1q molecule firmly in the membrane of macrophages, the C1q molecule can thus be classified as a type II membrane protein, functioning as an additional receptor for molecules known to react with C1q in fluid phase such as the Fc region of IgG, LPS and polyanionic molecules (e.g. chondroitin sulphate, heparin, dextran sulphate etc.). The various domains within the A-chain, and their respective functions (or potential functions), are presented and discussed in the context of the intact C1 molecule and with regard to any wider functional relevance.
Optical Properties of MEH-PPV Thin Films Containing ZnO Nanoparticles (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation N. Y. Zayana, S. S. Shariffudin, N. S. Jumali, Z. Shaameri, A. S. Hamzah, M. Rusop; Optical Properties of MEH‐PPV Thin Films Containing ZnO Nanoparticles. AIP Conference Proceedings 25 May 2011; 1341 (1): 72–76. https://doi.org/10.1063/1.3586957 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Hyperdopaminergic Mutant Mice Have Higher “Wanting” But Not “Liking” for Sweet Rewards (2003)

What is the role of dopamine in natural rewards? A genetic mutant approach was taken to examine the consequences of elevated synaptic dopamine on (1) spontaneous food and water intake, (2) incentive motivation and learning to obtain a palatable sweet reward in a runway task, and (3) affective “liking” reactions elicited by the taste of sucrose. A dopamine transporter (DAT) knockdown mutation that preserves only 10% of normal DAT, and therefore causes mutant mice to have 70% elevated levels of synaptic dopamine, was used to identify dopamine effects on food intake and reward. We found that hyperdopaminergic DAT knockdown mutant mice have higher food and water intake. In a runway task, they demonstrated enhanced acquisition and greater incentive performance for a sweet reward. Hyperdopaminergic mutant mice leave the start box more quickly than wild-type mice, require fewer trials to learn, pause less often in the runway, resist distractions better, and proceed more directly to the goal. Those observations suggest that hyperdopaminergic mutant mice attribute greater incentive salience (“wanting”) to a sweet reward in the runway test. But sucrose taste fails to elicit higher orofacial “liking” reactions from mutant mice in an affective taste reactivity test. These results indicate that chronically elevated extracellular dopamine facilitates “wanting” and learning of an incentive motivation task for a sweet reward, but elevated dopamine does not increase “liking” reactions to the hedonic impact of sweet tastes.
Pelizaeus-Merzbacher disease: a valine to phenylalanine point mutation in a putative extracellular loop of myelin proteolipid. (1991)

In the central nervous system, myelin proteolipid protein isoforms (PLP and DM20) play an essential structural role in myelination. It has been shown in several species that myelination is impaired by molecular defects resulting from single base mutations in the PLP gene. We have used DNA amplification by polymerase chain reaction to study the PLP gene coding regions from 17 patients in 15 unrelated families with similar Pelizaeus-Merzbacher phenotype. In one case amplification of peripheral nerve PLP/DM20 cDNAs revealed that a silent T----C transition was unrelated to the disease. In one family a nonsilent mutation was identified that leads to a phenylalanine substitution for valine-218 in PLP/DM20 proteins. We investigated the inheritance of the mutant allele in 19 subjects of this four-generation family and found a strict cosegregation of the Phe218 substitution with transmission and expression of the disease. The effect of the Val218----Phe mutation is discussed in the frame of a recently suggested topological model of PLP/DM20, according to which Val218 is part of an extracellular loop that connects the last two of four membrane-spanning alpha-helices.
A Mixed Instructional Methods Approach to Teaching a Circuits and Instrumentation Course (2015)

The circuits and instrumentation course at James Madison University provides students with foundational knowledge in DC, transient, and AC circuit design and analysis. The 4-credit course is comprised of three weekly lectures and one weekly laboratory session. Given the breadth of content and desired level of technical analysis required of this junior level course offering, numerous methods for extending learning beyond the classroom and encouraging student engagement with the material have been explored. Over the past five years, active learning instructional techniques inspired by the Process Oriented Guided Inquiry Learning (POGIL) approach and project based laboratory learning have been intermixed with traditional lectures and the flipped classroom method in an attempt to improve student learning. This paper reports on the variety of methods used, how each instructional method is integrated into the classroom environment, the rationale behind implementing the various techniques, and the observations and impacts on student outcomes. Quantitative assessments, based on embedded measures throughout the past five years as well as and concept inventory performance, are used to evaluate the effectiveness of the methods and changes implemented. Qualitative assessment of the instructional methods from post-course student evaluation comments are used to understand students' response to the instructional methods described.
Cold-Inducible Promoters for Heterologous Protein Expression (2003)

Rapid transfer of exponentially growing E. coli cultures from physiological to low temperatures (10–15#X00B0;C) has profound consequences on cell physiology: membrane fluidity decreases, which interferes with transport and secretion, the secondary structures of nucleic acids are stabilized, which affect the efficiencies of mRNA transcription/translation and DNA replication, and free ribosomal sub-units and 70S particles accumulate at the expense of polysomes, negatively impacting translation of most cellular mRNAs (1–3). It is therefore not surprising that cell growth and the synthesis of the vast majority of cellular proteins abruptly stop upon sudden temperature downshift (4). However, this lag phase is only transient, and growth resumes with reduced rates after 2-4 h incubation at low temperatures, depending on the genetic background (4,5). Such remarkable ability to survive drastic changes in environmental conditions is not atypical for E. coli, which has evolved multiple, often synergistic, adaptive strategies to handle stress. In the case of cold shock, the need for restoring transcription and translation is handled by an immediate increase in the synthesis of about 16 cold shock proteins (Csps) (4), while the cell solves the problem of membrane fluidity by raising the concentration of unsaturated fatty acids that are incorporated into membrane phospholipids (6). Interestingly, translation of the alternative sigma factor σ(suS), a global regulator of gene expression in E. coli, has been reported to increase at 20°C (7) suggesting that RpoS-dependent gene products may also play a role in cellular adaptation to mild—but probably not severe—cold shock.
Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors. (1995)

N-Methyl-D-aspartate (NMDA) receptors play an important role in the development of retinal axon arbors in the mammalian lateral geniculate nucleus (LGN). We investigated whether blockade of NMDA receptors in vivo or in vitro affects the dendritic development of LGN neurons during the period that retinogeniculate axons segregate into on-center and off-center sublaminae. Osmotic minipumps containing either the NMDA receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV) or saline were implanted in ferret kits at postnatal day 14. After 1 week, LGN neurons were intracellularly injected with Lucifer yellow. Infusion of D-APV in vivo led to an increase in the number of branch points and in the density of dendritic spines compared with age-matched normal or saline-treated animals. To examine the time course of spine formation, crystals of 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate were placed in the LGN in brain slices from 14- to 18-day-old ferrets. Labeled LGN cell dendrites were imaged on-line in living slices by confocal microscopy, with slices maintained either in normal perfusion medium or with the addition of D-APV or NMDA to the medium. Addition of D-APV in vitro at doses specific for blocking NMDA receptors led to a > 6-fold net increase in spine density compared with control or NMDA-treated slices. Spines appeared within a few hours of NMDA receptor blockade, indicating a rapid local response by LGN cells in the absence of NMDA receptor activation. Thus, activity-dependent structural changes in postsynaptic cells act together with changes in presynaptic arbors to shape projection patterns and specific retinogeniculate connections.
Conflict/Terrorism/ Civil Unrest (1986)

I would like to talk about the changing forms of warfare, terrorism in particular, and try to relate to you where you may have some involvement with the problem. First of all, let me tell you that terrorism, and I'm not going to seek to define it fully because no one has ever succeeded in doing so, is political extortion. It is the warfare of the weak. The terrorists generally use very low technology weapons, by this I mean, hand grenades, bombs, automatic weapons, pistols; but their logistical support is of the highest magnitude in terms of technology, things such as jet aircraft and instant global satellite communications. The most fundamental observation to make about terrorism is that it's theatre and very highly choreographed. Its purpose is to make large governments, particularly democracies which both enjoy and insist upon human dignity and human rights, look impotent. And we have been made to look impotent in my mind.
ChemInform Abstract: “Transmitted” Remote Double Diastereoselection Effects on the Asymmetric Reduction of β‐Boronate Oxime Ethers. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Measurement of Particle Sizes in Polydispersed Systems by Means of Light Transmission Measurements Combined with Differential Settling (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMeasurement of Particle Sizes in Polydispersed Systems by Means of Light Transmission Measurements Combined with Differential SettlingR. O. Gumprecht and C. M. SliepcevichCite this: J. Phys. Chem. 1953, 57, 1, 95–97Publication Date (Print):January 1, 1953Publication History Published online1 May 2002Published inissue 1 January 1953https://pubs.acs.org/doi/10.1021/j150502a020https://doi.org/10.1021/j150502a020research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
ChemInform Abstract: Synthesis of 2,5‐Dioxygenated Pyrazine 4‐Oxides: Total Synthesis of a New Inhibitor of Superoxide Anion Generation, OPC‐15161. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Combinatorial Strategies for the Induction of Immunogenic Cell Death (2015)

The term "immunogenic cell death" (ICD) is commonly employed to indicate a peculiar instance of regulated cell death (RCD) that engages the adaptive arm of the immune system. The inoculation of cancer cells undergoing ICD into immunocompetent animals elicits a specific immune response associated with the establishment of immunological memory. Only a few agents are intrinsically endowed with the ability to trigger ICD. These include a few chemotherapeutics that are routinely employed in the clinic, like doxorubicin, mitoxantrone, oxaliplatin, and cyclophosphamide, as well as some agents that have not yet been approved for use in humans. Accumulating clinical data indicate that the activation of adaptive immune responses against dying cancer cells is associated with improved disease outcome in patients affected by various neoplasms. Thus, novel therapeutic regimens that trigger ICD are urgently awaited. Here, we discuss current combinatorial approaches to convert otherwise non-immunogenic instances of RCD into bona fide ICD.
Shear elasticity quantification of cancerous tumors in mice, pre and post chemotherapy treatment (2012)

International audience
A Highly Sensitive Immunoassay Resistant to Autoantibody Interference for Detection of the Diabetes-Associated Autoantigen Glutamic Acid Decarboxylase 65 in Blood and Other Biological Samples (2006)

A sensitive, autoantibody-resistant GAD65 assay has been developed that is compatible with detection in serum and plasma and therefore will likely also work with a variety of other biologic fluids. This assay may enable the use of circulating GAD65 as a biomarker of islet damage or transplant rejection and will facilitate in vivo studies of the pathogenesis of anti-GAD65 autoreactivity.
Acid Proliferation Reactions and Their Application to Chemically Amplified Lithographic Imaging (1998)

Three kinds of acid amplifiers liberating sulfonic acids autocatalytically were developed. They include tert-butyl 2-methyl-2-tosyloxymethyl-3-keto-butanoate, 1-phenyl-1-(2-benzenesulfonyloxyethyl)-1,3-dioxolane and cis-1-hydroxyl-1-phenyl-2-tosyloxycyclohexane. These acid-sensitive compounds undergo autocatalytic decomposition to produce acidic species in a non-linear manner so that it is reasonable to refer these reactions as acid proliferation. The addition of every acid amplifier boosts photosensitivity of conventional chemically amplified photoresist systems and improves performances including photosensitivity and pattern profiles of a photoresist for 193 nm photolithography.
ChemInform Abstract: STUDIES ON THE SYNTHESES OF HETEROCYCLIC COMPOUNDS. DCCLII. CYCLIZATION REACTION OF AMIDO ALCOHOLS (1978)

Abstract Die Hydroxy‐carbonsäureamide (I) kondensieren mit Formaldehyd zu den Heterocyclen (III).
Dynamics of myosin light chain phosphorylation at Ser<sup>19</sup>and Thr<sup>18</sup>/Ser<sup>19</sup>in smooth muscle cells in culture (1998)

Using the specific antibodies pLC1 and pLC2 for mono- and diphosphorylated 20-kDa myosin light chain (MLC20) at Ser19 and at both Thr18 and Ser19, respectively, we visualized the dynamics of the MLC20 phosphorylation in rabbit aortic smooth muscle cells (cell line SM-3) stimulated with PGF2alpha. In the resting state, the diphosphorylated form was located in the peripheral region of the cell, such as the leading edge or the adhesion plaque, and the monophosphorylated form was located not only in the peripheral region but also on a discontinuous fibrillary structure along the long axis of the cell. After stimulation with 30 microM PGF2alpha, although localization of the monophosphorylated form changed little, the content of the diphosphorylated form increased and the distribution spread along the fibrillary structure to an extent the same as or similar to that of the monophosphorylated form, which colocalized with actin filament bundles. The diphosphorylation of MLC20 was more sensitive to protein kinase inhibitors, HA-1077, HA-1100, staurosporine, wortmannin, and ML-9, than was the monophosphorylation. In light of these observations, we propose that MLC20 diphosphorylation and monophosphorylation are regulated by different mechanisms.
CHORDOMA (1942)

A rare tumor, first correctly identified by Müller,<sup>1</sup>in 1858, is chordoma. Boldrey and McNally<sup>2</sup>found only 85 reported cases as of March 1941. Rea<sup>3</sup>quoted Cushing<sup>4</sup>as stating that chordoma occurs in the ratio of 1 to 1,800 among the tumors found in the region of the optic chiasm. Chordoma develops from remnants of the notochord at the junction of the dorsum sellae turcicae and the occipital bone. It may extend into the brain stem or forward into the nasopharynx. Boldrey and McNally<sup>2</sup>stated that 20 per cent of tumors diagnosed as chordoma are of the nasopharyngeal type and 80 per cent intracranial. In the case to be reported in this paper the tumor was of the latter type. In describing the notochord Piersol<sup>5</sup>stated: "Coincidently with the formation of the medullary groove the entoblast opposite the bottom of that furrow exhibits proliferation and thickening; the group of cells
ChemInform Abstract: Asymmetric Reactions of Thioacetals and Their S‐Oxides Derived from 1, 1′‐Binaphthalene‐2,2′‐dithiol. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.