gebhart/patrepeval huggingface dataset:
Orientation dependence of 2H NMR spin-lattice relaxation rates for cholesterol in macroscopically oriented multibilayers (1988)

International audience
Synthesis, structure, and tuberculostatic activity of dimethyl benzoylcarbonohydrazonodithioates (2011)

New dimethyl benzoylcarbonohydrazonodithioates were obtained by CS2 addition to arylcarboxylic acid hydrazides and methylation of the formed adduct. The new derivatives were tested for their activity against Mycobacterium tuberculosis. Some compounds exhibited high activity toward sensitive and resistant strains.
Glial and endothelial blood-retinal barrier responses to amyloid-&beta; in the neural retina of the rat (2008)

Peter JB Anderson1,a, HR Watts1,a, CJ Hille3, KL Philpott3, P Clark4, M Croucher, S Gentleman2, Ling-Sun Jen11Department of Cellular and Molecular Neuroscience; 2Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Charing Cross Hospital Campus, London, UK; 3Neurosciences, Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK; 4Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK; aThese researchers contributed equally to this paperAbstract: The effects of an intravitreal or subretinal injection of soluble or aggregated forms of A&beta;1&ndash;42 on retinal nestin-immunoreactivity (-IR) and glial fibrillary acidic protein (GFAP)-IR in astrocytes and M&uuml;ller glial cells and the integrity of the blood-retinal barrier (BRB) were tested in the in vivo rat vitreal-retinal model. Retinas were exposed for 1, 2, 3, 5 or 30 days. We present novel data demonstrating that aggregated A&beta;1&ndash;42 up-regulates nestin-IR in astrocytes and M&uuml;ller cells, with a graded response directly related to the length of pre-injection aggregation time. Similar results were obtained with GFAP-IR, but the signal was weaker. An intravitreal injection of aggregated A&beta;1&ndash;42 led to VEGF-IR up-regulation, particularly in the GCL and to a lesser extent in the INL. VEGFR1-IR (Flt1) was also increased, particularly in M&uuml;ller cells and this was accompanied by marked leakage of albumin into the retinal parenchyma of the injected eye, but not in the contralateral eye.Keywords: amyloid-&beta;, M&uuml;ller cells, blood-retinal barrier
Insulin stimulates the entry of GLUT4 into the endosomal recycling pathway by a quantal mechanism. (2004)

International audience
Multielement Crystalline and Pseudocrystalline Oxides as Efficient Catalysts for the Direct Transformation of Glycerol into Acrylic Acid (2014)

Glycerol surplus from biodiesel synthesis still represents a major problem in the biofuel production chain. Meanwhile, those in the acrylic acid market are looking for new processes that are able to offer viable alternatives to propylene-based production. Therefore, acrylic acid synthesis from glycerol could be an effective solution to both issues. Among the viable routes, one-pot synthesis theoretically represents the most efficient process, but it is also highly challenging from the catalyst design standpoint. A new class of complex W--Mo--V mixed-oxide catalysts, which are strongly related to the hexagonal tungsten bronze structure, able to directly convert glycerol into acrylic acid with yields of up to 51 % are reported.
Origin and solution of finite extinction ratios in Ti:LiNbO3 directional coupler switches (1986)

Ti:LiNbO 3 directional coupler switches have consistently shown an extinction ratio in the −15 to −30-dB range but only rarely <−30 dB. This is illustrated by a set of 16 nominally identical directional coupler switches recently fabricated on a single substrate. 1 An approximately random distribution of extinction ratios was measured ranging from −11.6 to <−35 dB. In addition, their response curves show nonideal behavior, such as unequal side lobes and nonzero voltage values for the maxima of the crossed state. We hypothesize and demonstrate that there is a common explanation for all these nonideal characteristics: random fluctuations in the effective index along the length of the diffused waveguide. Local random variations in the Ti concentration of the diffused waveguide could produce random fluctuations in their effective index.
Using Electrocapillarity to Measure the Zeta Potential of a Planar Hydrophobic Surface in Contact with Water and Nonionic Surfactant Solutions (2008)

A method is introduced for determining the zeta potential of planar surfaces by combining electroosmosis and capillarity. In this method, an electric field is applied across the channel, which is filled with aqueous solution seeded with fluorescent tracer particles. Some excess liquid is applied on both ends of the channel, which bulges out and modulates the capillary force across the channel by adjusting its curvature. While the velocity profile in the channel approaches steady state, a balance of the electroosmotic stress and Laplace pressure difference is achieved across the channel. However, as soon as the electric field is turned off, a Poiseuille flow develops in the channel due to the difference in the curvatures of the liquid bulges. We show that the measurement of the centerline velocity of the liquid inside the channel is enough to deduce the zeta potential of the surface. Utilizing this technique, the zeta potential of a hydrophobic glass surface (silanized by n-hexadecyltrichlorosilane, HC-16) has been measured to be -52.2 +/- 7.7 mV in distilled deionized water, which is in close agreement with the literature values. This technique has also been used to estimate the zeta potential of the HC-16 surface (zeta w(HC-16)), in the presence of the aqueous solutions of polyoxyethylene (23) lauryl ether (Brij 35). The zeta potential here at first becomes more negative than that in pure water, it stays flat for a while, and then it continues to become less negative as the concentration of the surfactant increases above the critical micelle concentration (CMC). This effect, where changes take place beyond the CMC but not below it, leads to a complementary Gibbs plot, where all the changes occur below the CMC but not above it. It is conjectured that the scavenging of hydroxyl ions by the Brij 35 micelles may be responsible for the observed effect.
Effects of Ciprofloxacin, Streptomycin, and Gentamicin on Rabbit Corneal Transendothelial Electrical Potential Difference (1998)

Our study shows that concentrations of ciprofloxacin, gentamicin, and streptomycin below or equal to their MIC90 levels do not adversely affect endothelial transport function in a rabbit model.
Proton ejection in photoactive quinone systems (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton ejection in photoactive quinone systemsKenneth P. QuinlanCite this: J. Phys. Chem. 1969, 73, 6, 2058–2059Publication Date (Print):June 1, 1969Publication History Published online1 May 2002Published inissue 1 June 1969https://pubs.acs.org/doi/10.1021/j100726a071https://doi.org/10.1021/j100726a071research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A High-Affinity Gold-Binding Camel Antibody: Antibody Engineering for One-Pot Functionalization of Gold Nanoparticles as Biointerface Molecules (2012)

Antibodies, with their high affinity and specificity, are widely utilized in the field of protein engineering, medicinal chemistry, and nanotechnology applications, and our recent studies have demonstrated the recognition and binding of antibody for the surface on inorganic material. In this study, we generated a high-affinity gold-binding antibody fragment by a combination of peptide-grafting and phage-display techniques and showed the availability of the material-binding fragment for one-pot functionalization of nanoparticles as interface molecules. After a gold-binding peptide sequence was grafted into one of the complementarity determining regions of a single variable domain of a heavy-chain camel antibody, a combinatorial library approach raised by 20 times the affinity of the peptide-grafted fragment. The high-affinity gold-binding fragment (E32) spontaneously adsorbed on gold nanoparticles, and consequently the nanoparticles formed a stable dispersion in a high-ionic-strength solution. Multivalent and bispecific antibodies constructed on the E32 platform by means of fusion technology functionalized gold nanoparticles in one pot, and these functionalized nanoparticles could be used to obtain surface plasmon resonance scattering images of cancer cells and to spontaneously link two different nanomaterials. Here, we propose the bispecific antibodies as convenient interface molecules in the nanosized world.
A SURVEY OF INTEROPERABILITY IN E-HEALTH SYSTEMS - The European Approach (2008)

The interoperability is often associated with the capacity of exchanging information that belongs to different workflows in a distributed environment. In e-health, the implementation of interoperable systems has a direct impact on the access of medical services, the costs and the quality of those services. This paper summarizes the efforts of standardization done by a selected group of Europeans researchers in the healthcare domain. The assessment of this standardization effort is made through a study of its impact in 20 FP5 and FP6 European projects that address the healthcare domain. The objectives are identify the new trends on interoperability technologies and to point out the importance of approximate industrials and research institutes.
Reaction of Benzyne with Salicylaldehydes: General Synthesis of Xanthenes, Xanthones, and Xanthols (2008)

The reaction of salicylaldehydes with benzyne prepared from o-trimethylsilyphenyl triflate and CsF gave xanthenes and xanthones. When the reaction was carried out under basic conditions, 9-hydroxyxanthenes (xanthols) were obtained in good yields.
ChemInform Abstract: Synthetic Utilization of Highly Stereoselective Conjugate Addition Reactions of Phosphorus and Sulfur Stabilized Allylic Carbanions (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Studies of Heparin Binding to Antithrombin III by Crossed Immunoelectrophoresis (1979)

The technique of crossed immunoelectrophoresis has been used to study the binding to purified antithrombin III (At III) of heparin and other mucopolysaccharides. The technique was unable to detect differences among samples of whole heparin from various manufacturers, but proved useful in studying the binding of heparin fractions; at the same molarities, low and high molecular weight heparin fractions displayed equal binding ability to At III. A semi-synthetic heparin analogue showed no evidence of binding to At III, but a sample of heparan sulphate did interact with At III at a concentration 3 times that of heparin. Samples of purified At III from four different manufacturers all displayed heterogeneity with respect to heparin binding. A proportion of the total At III did not bind to heparin and, in one sample, this non-binding material constituted about 40% of the total. An antiserum made against purifed At III contained antibodies with different cross-reactivities against heparin bound and non-heparin bound At III.
Multicast routing algorithms for the WDM Shufflenet local optical network (2002)

We propose an efficient algorithm for constructing multicast trees in the Shufflenet. Although the Shufflenet has been shown to be an important network topology for wavelength division multiplexed (WDM) local optical networks, no algorithm has previously been proposed for multicasting in this network. We present a single-pass algorithm that constructs minimum-delay multicast trees, and show how a second pass can be added to reduce tree cost while maintaining very low delay.
Curing process of powdered phenol–formaldehyde resol resins and the role of water in the curing systems (2003)

Abstract The curing behavior of two kinds of commercial powdered resol phenolic resins was studied by differential scanning calorimetry. Liquid‐state 13 C‐NMR spectroscopy was used to aid in understanding the curing behavior by detecting the structure of powdered resins. The reaction mechanism was interpreted with the dependency of activation energy on the degree of conversion. The results indicate that there are differences in the curing mechanism between core and face phenolic resins. The curing process of core resin was faster than that of face resin at the same reaction temperature. The water added in the curing system played an important role of plasticizer or diluent according to different curing stages and water content. In the initial curing stage, water mainly diluted the system and retarded the curing reactions. However, at the higher degrees of conversion, water played the role of plasticizer to decrease the effect of diffusion on the curing reactions to make the curing reactions more complete. The excess water added in the curing system played the role of diluent at almost all stages during the curing process. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 1371–1378, 2003
Evaluation of the Performance of a Point-of-Care Test for Chlamydia and Gonorrhea (2020)

This study suggests that self-obtained vaginal swab samples were associated with performance equivalent to laboratory-based molecular diagnostics, which can support use of this POC assay in many settings. The availability of an easy-to-use, rapid (30-minute) molecular test for accurate detection of chlamydia and gonorrhea has the power to facilitate testing and treatment in a single patient visit for these STIs.
Automated Synthesis of Assertion Monitors using Visual Specifications (2005)

Automated synthesis of monitors from high-level properties plays a significant role in assertion-based verification. We present a methodology to synthesize assertion monitors from visual specifications given in CESC (Clocked Event Sequence Chart). CESC is a visual language designed for specifying system level interactions involving single and multiple clock domains. It has well-defined graphical and textual syntax and formal semantics based on a synchronous language paradigm enabling formal analysis of specifications. We provide an overview of the CESC language with a few illustrative examples. The algorithm for automated synthesis of assertion monitors from CESC specifications is described. A few examples from standard bus protocols (OCP-IP and AMBA) are presented to demonstrate the application of the monitor synthesis algorithm.
Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease (2015)

Paget's disease of bone (PDB) is a common disease characterized by osteoclast activation that leads to various skeletal complications. Susceptibility to PDB is mediated by a common variant at the optineurin (OPTN) locus, which is associated with reduced levels of mRNA. However, it is unclear how this leads to the development of PDB. Here, we show that OPTN acts as a negative regulator of osteoclast differentiation in vitro and that mice with a loss-of-function mutation in Optn have increased osteoclast activity and bone turnover. Osteoclasts derived from Optn mutant mice have an increase in NF-κB activation and a reduction in interferon beta expression in response to RANKL when compared to wild-type mice. These studies identify OPTN as a regulator of bone resorption and are consistent with a model whereby genetically determined reductions in OPTN expression predispose to PDB by enhancing osteoclast differentiation.
Magnetic Stress Gages for Torque and Load Monitoring in Rotorcraft (2008)

The noncontact, reusable torque and stress gages discussed in this paper address the need for enhanced torque measurement capability for main and tail rotorshafts, as well as for convenient stress/load monitoring at critical locations for diagnostic and health monitoring purposes. Results of static tests at JENTEK and full-scale dynamic tests at Boeing are described. This paper also describes the Magnetic Stress Gage and how it overcomes many of the stated limitations of other stress measurement methods based on magnetic permeability. This is achieved by using a multidirectional, model-based approach to remove the effects of hysteresis, temperature, material property variation, stray magnetic fields, and other interferences. This method also offers the capability to monitor stress, with a reusable gage, through paint and with limited or no surface preparation. These capabilities are enabled by: (1) the MWM ® (Meandering Winding Magnetometer) design, (2) a rapid model-based multivariate inverse method, and (3) unique parallel architecture impedance instrumentation (patents issued and pending).
The Microbiome and Primary Sclerosing Cholangitis (2016)

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with detrimental sequela. In many patients, PSC progresses to end-stage liver disease and hepatobiliary cancer. There is no medical therapy that is proven to halt or reverse the progression of PSC. Approximately 70 to 80% of PSC patients have inflammatory bowel disease, usually ulcerative colitis. The etiology of PSC is poorly understood. Several lines of evidence suggest that the intestinal microbiota plays an important role in the etiopathogenesis of PSC. Stemming from this theory, several antibiotics have been tried in PSC, some of which had shown promising results. Fecal microbiota transplantation is a novel therapy, and is currently being investigated as a potential therapeutic strategy in PSC along with probiotics. In this article, the authors discuss the current knowledge of the intestinal microbiota in PSC.
REM-sleep changes in children with attention-deficit/hyperactivity disorder: methodologic and neurobiologic considerations. (2004)

clinically defined groups may have included subjects with different ADHD phenotypic profiles and coexisting problems. Both the phenotypic profile and comorbidity factors seem to be related to the variance of the neurobiologic background of ADHD.6 Hence, the decreased REM sleep that was identified in children with ADHD who were recruited from the general population may be correlated to learning and memory-consolidation problems,3 whereas the increased REM sleep in clinically diagnosed ADHD groups4,5 may be more closely linked with the monoaminergic pathophysiologic mechanisms of the core ADHD symptoms. Other sources of variation that should be controlled for in sleep research of ADHD include the first-night effect, medication status, and precise matching of the samples. Because there is substantial evidence that ADHD psychopathology and sleep-wake regulation share common neurobiologic mechanisms,1,2,4 we suggest that sleep research in ADHD may be advanced more productively by applying comparable methodologic approaches that carefully consider the heterogeneity of ADHD and its associated disturbances. REFERENCES
The Singular Optical Properties of Phthalocyanines: From Photosensitizers for Photodynamic Therapy to Nonlinear Optical Applications (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Water‐Soluble imide‐amide copolymers. II. Preparation and characterization of poly (acrylamide‐co‐<i>p</i>‐maleimidobenzoic acid) (1990)

Abstract The comonomer required, p ‐maleimidobenzoic acid (MBA) was first prepared in good yield by refinements of published methods. p ‐Carboxysuccinanilic acid (CSA), and p ‐succinimidobenzoic acid (SBA), were also prepared to provide models useful for IR and NMR for spectroscopic assignments of the new copolymers. Polymerization of MBA with acrylamide in glacial acetic acid at 60°C gave copolymers with estimated viscosity average molecular weights of 60,000 to 90,000. Yields and viscosity average molecular weights decreased as the MBA to acrylamide monomer feed ratio was increased. The rate of incorporation of MBA into the copolymer rose from 7 to 23% when the mole ratio in the feed was raised from 5 to 20%. Decreasing the initiator concentration increased molecular weights by less than predicted and reduced the yield of copolymer for any given feed ratio of MBA to acrylamide. In all cases about 30–40% of the MBA units in the purified copolymers were hydrolyzed. A change to dimethyl sulfoxide solvent gave good, and poor yields of copolymer at 5 and 10 mol % MBA, respectively, and no copolymer at 20 mol % MBA. Viscosity average molecular weights of the copolymer products prepared in DMSO were somewhat lower than obtained for the copolymers prepared in acetic acid. Polymerization in a DMSO‐water mixture gave a negligible yield of polymeric product. Instead, only hydrolysates of MBA precipitated when the coloured polymerization solutions were added to methanol.
Anti-Müllerian Hormone (AMH) regulates BRCA1 and BRCA2 gene expression after ovarian cortex transplantation (2020)

Administration of rAMH in the peri-transplant period caused downregulation of BRCA1, but not of BRCA2 expression, in human ovarian cortex. These results help our understanding of DNA repair mechanism in the ovarian cortex and identify AMH's possible protective effect on ovarian reserve in BRCA1 mutation carriers.
Lysis of Gram-Negative Bacteria by Host-Independent Ectoparasitic Bdellovibrio bacteriovorus Isolates (1965)

SUMMARY Methods of isolation and nutritional requirements of Bdellovibrio bacteriovorus strains capable of growth on host-free media are described. Such strains retained their parasitic capacities for various Gram-negative bacteria after many transfers in host-free media. In parasite +host suspensions the spectrum of host specificity of various bdellovibrio strains was considerably wider than that obtained by examination for plaques on host lawns. The growth conditions therefore affect the capacity of the bdellovibrios to attach to and lyse host organisms. A proteolytic exoenzyme formed by certain bdellovibrio strains digested heat-killed, acid-treated or EDTA-treated host organisms, but did not affect intact host organisms. High phosphate concentrations inhibited exoenzyme activity. The morphological sequence of lysis induced by exoenzyme-forming parasitic bdellovibrio strains suggested that this lysis was a two-stage process: the first stage was specific attachment of bdellovibrios with damage to the cell wall of the host organisms ; the second stage was non-specific digestion of cellular components by exoenzyme produced by the bdellovibrios.