gebhart/patrepeval huggingface dataset:
Primary structure of the Escherichia coli folC gene and its folylpolyglutamate synthetase-dihydrofolate synthetase product and regulation of expression by an upstream gene. (1987)

The nucleotide sequence of the gene for folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase (folC) has been determined. The deduced amino acid sequence codes for a protein of Mr 45,380 and contains regions with homology to the A and B regions of ATP-binding sites. The folC gene is adjacent to a gene located 70 base pairs upstream of the initiation codon for folC. The nucleotide sequence of this upstream gene was also determined. Deletion of the upstream gene sequences from recombinant plasmids containing the folC gene results in about a 100-fold decrease in plasmid-dependent folylpolyglutamate synthetase activity, suggesting that the major promoter for folC is 5' to the upstream gene. The upstream gene codes for a protein of Mr 33,346, which is expressed in maxicells and amplified in cells containing the upstream gene in recombinant pUC8 plasmids. Expression of the upstream gene in maxicells was greater than that of folC, as determined by the intensity of 35S-labeled proteins after sodium dodecyl sulfate-gel electrophoresis. A region of dyad symmetry exists between the coding sequences of the two genes which may code for a transcription termination signal and be responsible for the attenuation of the expression of the folC gene relative to the upstream gene. The folC gene is located about 1 kilobase upstream of the purF gene region at 50 min on the Escherichia coli map. The function of the upstream gene product is unknown. It contains sequences with homology to metal-binding domains in nucleic acid-binding proteins. A new purification procedure for obtaining large quantities of folylpolyglutamate synthetase-dihydrofolate synthetase is described.
Physiologically inspired neural model for the prototype-referenced encoding of faces (2004)

Due to the lack of electrophysiological data the neural basis of the encoding of faces is largely unclear. We present a model for the neural encoding of face spaces that is based on new electrophysiological results. It reproduces important properties of the physiological data and shows that faces might be encoded exploiting a \\em norm-based rather than an \\em examplebased neural representation. This implies that the encoding exploits an internal representation of an average (norm) face that might be derived by averaging over the previous stimulus history.
The immunohistochemical detection of cripto-1 in benign and malignant human bladder (1998)

The recently identified epidermal growth factor-related peptide cripto-1 has been previously implicated in the development of the malignant phenotype. The identification of gene products that can act as prognostic markers in bladder cancer would be value in determining the management of this heterogeneous group of patients. This study examines cripto-1 expression in benign and malignant bladder using immunohistochemical techniques. The expression of cripto-1 protein in benign and malignant bladder was examined in 45 bladder tumours (Ta/T1 n = 26, T2 n = 5, T3/T4 n = 14) and six benign controls. All 45 tumours showed positive cytoplasmic staining for cripto-1, including areas of carcinoma in situ. None of the six benign controls showed any evidence of positive cripto-1 staining. Twenty-three (60 per cent) bladder tumours had areas of papillary tumour that showed strong positive staining for cripto-1 as opposed to six (29 per cent) sections of histologically normal urothelium adjacent to tumour (P < 0.05). There was no association between cripto-1 staining and tumour grade, stage, or clinical outcome. Cripto-1 protein appears to be specifically expressed in malignant and benign adjacent urothelium of patients with bladder cancer. Its clinical significance, however, remains to be determined.
LandEx—A GeoWeb Tool for Query and Retrieval of Spatial Patterns in Land Cover Datasets (2013)

The vast amount of data collected by satellites via remote sensing is a valuable resource, however, it lacks machine search capabilities. In particular, large land cover datasets, such as the 30-m/cell NLCD 2006 covering the entire conterminous United States, are rarely analyzed as a whole due to the lack of tools beyond the basic statistics and SQL queries. Consequently, the NLCD is underutilized relative to its potential. We address this issue by introducing LandEx-a GeoWeb application for real time, content-based exploration and mining of land cover patterns in large datasets. By combining the functionality of online computerized maps with the power of the pattern recognition algorithm, LandEx provides an easy to use visual search engine for the entire extent of the NLCD at its full resolution. The user selects a pattern of interest (a query) and the tool produces a similarity map indicating the spatial distribution of locations having patterns of land cover similar to that in the query. Pattern-based query and retrieval addresses the issue of structural similarity between landscapes. The core of the method is the similarity function between two patterns which is based on 2D land cover class/clump size histograms and the Jensen-Shannon divergence. The search relies on exhaustive evaluation using an overlapping sliding window approach. LandEx is implemented using Free Open Source Software (FOSS) software and adheres to the Open Geospatial Consortium (OGC) standards. The wait time for an answer to a query is only several seconds due to the high level of system optimization. The methodology and implementation of LandEx are described in detail and illustrative examples of its application to different domains, including agriculture, forestry, and urbanization are given.
GENETIC ANALYSIS OF MUTATIONS AT THE <i>GLUED</i> LOCUS AND INTERACTING LOCI IN <i>DROSOPHILA MELANOGASTER</i> (1982)

A genetic analysis of the dominant mutation Glued that perturbs the development of the normal axonal architecture of the fly's visual system was undertaken. Ten new alleles at this locus were identified and characterized. Two complementation groups that were identified failed to complement the original allele, suggesting that it is a double mutant or that it resides at a complex locus. Several of the new alleles display visual-system abnormalities similar to those of the original mutation. Seven of the eight members of one complementation group are embryonic/early larval lethals, like the original mutation. The other allele in this group is temperature sensitive. Homozygous mutant adults exhibit a temperature-sensitive female sterile phenotype. Unsuccessful attempts to recover genetic mosaics carrying clones of cells homozygous for some of these mutations revealed that they are either essential for the viability of individual cells or that they affect some other fundamental cellular function, such as mitosis or the ability to participate in tissue level organization, which prevents them from being recovered in adult mosaics. This also indicates that these mutations do not specifically affect neural cells. A number of X-ray- and EMS-induced partial and complete phenotypic "revertants" of the original allele have also been isolated as material for comparative analysis of visual system development. All "revertants" that alter the abnormal eye phenotype towards the wild type have similar impact on the organization of the optic lobe.
Notes on the Pseudoscorpionida (1895)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Diversity in Tissue Expression, Substrate Binding, and SCF Complex Formation for a Lectin Family of Ubiquitin Ligases (2008)

Post-translational modification of proteins regulates many cellular processes. Some modifications, including N-linked glycosylation, serve multiple functions. For example, the attachment of N-linked glycans to nascent proteins in the endoplasmic reticulum facilitates proper folding, whereas retention of high mannose glycans on misfolded glycoproteins serves as a signal for retrotranslocation and ubiquitin-mediated proteasomal degradation. Here we examine the substrate specificity of the only family of ubiquitin ligase subunits thought to target glycoproteins through their attached glycans. The five proteins comprising this FBA family (FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44) contain a conserved G domain that mediates substrate binding. Using a variety of complementary approaches, including glycan arrays, we show that each family member has differing specificity for glycosylated substrates. Collectively, the F-box proteins in the FBA family bind high mannose and sulfated glycoproteins, with one FBA protein, FBX044, failing to bind any glycans on the tested arrays. Site-directed mutagenesis of two aromatic amino acids in the G domain demonstrated that the hydrophobic pocket created by these amino acids is necessary for high affinity glycan binding. All FBA proteins co-precipitated components of the canonical SCF complex (Skp1, Cullin1, and Rbx1), yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. Using subunit-specific antibodies, we further demonstrate marked divergence in tissue distribution and developmental expression. These differences in substrate recognition, SCF complex formation, and tissue distribution suggest that FBA proteins play diverse roles in glycoprotein quality control.
Intramolecular Hydrogen Bonding in cis-2-Phenylmercaptoindanol (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular Hydrogen Bonding in cis-2-PhenylmercaptoindanolH. Harry Szmant and Juan J. RigauCite this: J. Org. Chem. 1966, 31, 7, 2288–2290Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://pubs.acs.org/doi/10.1021/jo01345a048https://doi.org/10.1021/jo01345a048research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gonadal dysgenesis in individuals with apparently normal chromosomal complements: tabulation of cases and compilation of genetic data. (1971)

Although usually associated with an abnormal sex chromosomal complement, gonadal dysgenesis is occasionally detected in individuals having apparently normal male (46,XY) or female (46,XX) chromosomal complements. Six individuals with XY or XX gonadal dysgenesis, four proven, two probable, are described. A review of histologically verified cases of XX and XY gonadal dysgenesis reveals frequent familial aggregation of affected individuals, a situation rarely encountered in the more frequent X-monosomic gonadal dysgenesis. Multiple affected sibs and frequent X-monosomic gonadal dysgenesis. Multiple affected sibs and frequent parental consanguinity suggest that XX gonadal dysgenesis is an autosomal recessive condition, while certain families suggest that XY gonadal Dysgenesis is an X-linked recessive or male-limited autosomal dominant condition.
Magnetically Recoverable Ruthenium Catalysts in Organic Synthesis (2014)

Magnetically recyclable catalysts with magnetic nanoparticles (MNPs) are becoming a major trend towards sustainable catalysts. In this area, recyclable supported ruthenium complexes and ruthenium nanoparticles occupy a key place and present great advantages compared to classic catalysts. In this micro-review, attention is focused on the fabrication of MNP-supported ruthenium catalysts and their catalytic applications in various organic syntheses.
New texture signatures and their use in rotation invariant texture classification (2002)

Abstract-- In this paper, we present a theoretically and computationally simple but efficient approach for rotation invariant texture classification. This method is based on new texture signatures extracted from spectrum. Rotation invariant texture features are obtained based on the extension of the derived signatures. The features are tested with 1000 randomly rotated samples of 20 Brodatz texture classes. Comparative study results show that our method is highly efficient in rotation invariant texture classification. 1.
Emulsion Polymerization Mechanism (2018)

Emulsion polymerization is a polymerization process with different applications on the industrial and academic scale. It involves application of emulsifier to emulsify hydrophobic polymers through aqueous phase by amphipathic emulsifier, then generation of free radicals with either a water or oil soluble initiators. It characterized by reduction of bimolecular termination of free radicals due to segregation of free radicals among the discrete monomer-swollen polymer particles. The latex particles size ranged from 10 nm to 1000 nm in a diameter and are generally spherical. A typical of particle consist of 1–10,000 macromolecules, where macromolecule contains about 100–106 monomer units.
Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta‐analysis (2005)

Most observational studies show an association between melatonin and cancer in humans. We conducted a systematic review of randomized controlled trials (RCTs) of melatonin in solid tumor cancer patients and its effect on survival at 1 yr. With the aid of an information specialist, we searched 10 electronic databases from inception to October 2004. We included trials using melatonin as either sole treatment or as adjunct treatment. Prespecified criteria guided our assessment of trial quality. We conducted a meta-analysis using a random effects model. We included 10 RCTs published between 1992 and 2003 and included 643 patients. All trials included solid tumor cancers. All trials were conducted at the same hospital network, and were unblinded. Melatonin reduced the risk of death at 1 yr (relative risk: 0.66, 95% confidence interval: 0.59-0.73, I2=0%, heterogeneity P<or=0.56). Effects were consistent across melatonin dose, and type of cancer. No severe adverse events were reported. The substantial reduction in risk of death, low adverse events reported and low costs related to this intervention suggest great potential for melatonin in treating cancer. Confirming the efficacy and safety of melatonin in cancer treatment will require completion of blinded, independently conducted RCTs.
Investigation of the morphology–catalytic reactivity relationship for Pt nanoparticles supported on alumina by using the reduction of NO with CH4 as a model reaction (2002)

The morphological evolution of large Pt nanoparticles supported on alumina in reaction conditions has a significant impact on the catalytic behaviour for the NO/CH4 reaction.
A NEW SYNTHESIS OF PRUMYCIN (1976)

Abstract Prumycin (4-d-alanylamino-2-amino-2,4-dideoxy-l-arabinose) was synthesized from d-xylose through nine-step conversions.
A Data Flow Approach to Color Gamut Visualization (1997)

Software has been developed to help engineers visualize the gamuts of color hardcopy devices. Software modules have been written so that color gamuts and color space transformations can be explored using a scientific visualization program. Tools have been created that allow the user to accentuate the differences between gamuts and to interact with the displayed data. The data flow architecture of the program makes it easy to add more color gamuts and to investigate additional color transformations.
Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines (2005)

High basal protein levels of GRP94 were correlated with a modest decrease in sensitivity to X-ray cell death in some cervical cancer cell lines. These results suggest that higher GRP94 protein expression is one of the molecular mechanisms causing resistance to radiation, and therefore GRP94 siRNA might be useful in tumor-specific gene therapy by reversing radio-resistance prior to radiation in cervical cancer.
Recycling, production and use of reprocessed rubbers (1991)

This article examines the various methods used to produce recycled rubber and to compare their characteristics and application. The topics discussed include reclaiming by chemical digestion, devulcanization by the severing of sulfur bonds, ambient temperature and cryogenically ground rubber, processing and mixing of ground rubber, and properties of reclaimed rubbers by reclamation method.
A novel allele in the promoter of the hepatic lipase is associated with increased concentration of HDL-C and decreased promoter activity (2002)

Hepatic lipase (HL) is a lipolytic enzyme involved in the metabolism of plasma lipoproteins, especially HDLs. Association of the polymorphisms in the promoter region of the LIPC gene to post-heparin plasma HL activity and the plasma HDL-C concentration has been investigated thoroughly, but to date little is known about this in the Chinese. In the present study, we analyzed the polymorphisms in the promoter region of LIPC gene in Chinese patients with coronary artery disease (CAD) using denaturing high performance liquid chromatography (DHPLC) and DNA sequencing. As the result, a novel single nucleotide polymorphism -586T-to-C was identified and no linkage of this variant with other polymorphisms in the promoter was found. Compared with the nonsymptomatic control subjects, excess of carriers of the -586T/C substitution were detected in the CAD patients (43% vs. 31%, chi(2) = 4.597, degree of freedom = 2, P = 0.032). The -586C allele carriers in the CAD patients had a significantly higher HDL-C level than the noncarriers (1.13 +/- 0.24 mmol/l vs. 0.91 +/- 0.14 mmol/l, P < 0.05). To test the functionality of this substitution, luciferase-reporter assays was performed in HepG2 cells. Promoter activity of the -586C construct was decreased 2-fold than the -586T construct. Our studies suggest that a T-to-C substitution at -586 of the LIPC promoter is associated with a lowered HL activity and that this variation may contribute to the increased plasma HDL-C concentration in the Chinese.
A Ku-band oscillator subsystem using a broadband GaAs MMIC push-pull amplifier/doubler (1991)

The design and performance results of a Ku-band voltage controlled oscillator subsystem using a broadband GaAs MMIC (monolithic microwave integrated circuit) push-pull amplifier as a frequency doubler are described. The subsystem utilizes both GaAs MMIC and Si bipolar technologies to achieve the desired performance objectives. The oscillator subsystem is tunable over the 14-18-GHz frequency range with a minimum output power of 18 dBm and a phase noise of -88 dBc/Hz at 100-kHz offset from the carrier over a 0 to +65 degrees C temperature range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adverse Selection and Moral Hazard in a Voluntary Deposit Insurance System: Evidence from Taiwanfs Credit Department of Farmersf Institutions (2001)

Since the deposit insurance system of Taiwan was enacted in 1985, it was run under a voluntary basis with a fixed insurance premium rate till 1998. As any kind of insurance, the system is very likely to emerge the problems of adverse selection and moral hazard in essence. By using the data of the credit department of farmersf institutions (CDFIs) in Taiwan, this paper attempts to identify whether the deposit insurance induced the problems of adverse selection and moral hazard. The empirical result shows that CDFIs with relatively small size tend to join deposit insurance first, but it is not significant that they belong to the risk-prone group. Moreover, compared with the uninsured CDFIs, those joined deposit insurance in the years of 1995 and 1996 are big in size and with lower ratio of over-due loan to total loan. Thus, evidence concludes the problem of adverse selection did not emerge. As regards moral hazard, we find that the risk of CDFIs is increasing after joining deposit insurance when the risk is measured by the ratio of over-due loan to total loan and by the ratio of liquidity.

Key words:deposit insurance, adverse selection, moral hazard, credit department of farmersf institutions, JEL classification: G21, G28
Malware classification method via binary content comparison (2012)

With the wide spread uses of the Internet, the number of Internet attacks keeps increasing, and malware is the main cause of most Internet attacks. Malware is used by attackers to infect normal users' computers and to acquire private information as well as to attack other machines. The number of new malware and variants of malware is increasing every year because the automated tools allow attackers to generate the new malware or their variants easily. Therefore, performance improvement of the malware analysis is critical to prevent malware from spreading rapidly and to mitigate damages to users. In this paper, we proposed a new malware classification method by analyzing similarities of malware. Our method analyzes a small part of malware to reduce analysis overheads, and experimental results showed that our approach can effectively classify malware families.
Application of the planar I/O terminal to dual-mode dielectric-waveguide filters (2000)

Planar input/output terminals have been applied to dual-mode dielectric-waveguide filters. Two types of filter, for a 13-GHz Ku-band and a 22-GHz K-band were designed and fabricated only by metal plating on the surfaces of a ceramic block. They are realized with very small volumes of less than 0.05 cm/sup 3/.
Fungal skin infections associated with animal contact. (1991)

Zoophilic dermatophytes are fungal organisms that primarily infect animals but occasionally infect humans. The most common of these are Microsporum canis and Trichophyton mentagrophytes. The clinical lesions of zoophilic fungal infections are more inflammatory than those caused by the typical anthropophilic fungi normally transmitted from person to person. To diagnose zoophilic fungal infections, a potassium hydroxide preparation of the skin scrapings may be examined microscopically or a culture may be obtained. Small lesions located anywhere except on the scalp may be treated with a topical antifungal agent. Oral griseofulvin is preferred for the treatment of scalp infections and extensive cutaneous infections.
The <i>Prestige</i> Oil Spill. 2. Enhanced Biodegradation of a Heavy Fuel Oil under Field Conditions by the Use of an Oleophilic Fertilizer (2006)

A field bioremediation assay using the oleophilic fertilizer S200 was carried out 10 months after the Prestige heavy fuel-oil spill on a beach of the Cantabrian coast (North Spain). The field survey showed that S200 significantly enhanced the biodegradation rate, particularly of high molecular weight n-alkanes, alkylcyclohexanes, and benzenes, and alkylated PAHs, paralleling the results previously found in vitro. The most significant molecular bioremediation indicators were the depletion of diasteranes and C-27 sterane components. Enhanced isomeric selectivity was also observed within the C1-phenanthrenes and dibenzothiophenes. Through the analysis of some target aliphatic and aromatic hydrocarbons a number of chemical indicators for assessing the efficiency of field bioremediation as well as identifying the source of highly weathered samples collected in the area after the spill are defined.