gebhart/patrepeval huggingface dataset:
Core 1 Glycans on α-Dystroglycan Mediate Laminin-induced Acetylcholine Receptor Clustering but Not Laminin Binding (2003)

Although unique O-linked oligosaccharides on alpha-dystroglycan are important for binding to a variety of extracellular ligands, the function(s) of more generic carbohydrate structures on alpha-dystroglycan remain unclear. Recent studies suggest a role for glycoconjugates bearing the core 1 disaccharide Galbeta(1-3)GalNAc in acetylcholine receptor (AChR) clustering on the surface of muscle cells. Here, we report experiments demonstrating that the core 1-specific lectin jacalin almost completely abrogated laminin-induced AChR clustering in C2C12 myotubes and that alpha-dystroglycan was the predominant jacalin-binding protein detected in C2C12 myotube lysates. Although jacalin likely inhibited laminin-induced AChR clustering by directly binding to alpha-dystroglycan, jacalin had no effect on laminin binding to the myotube surface or to alpha-dystroglycan. Like jacalin, peanut agglutinin lectin also binds the core 1 disaccharide but not when it is terminally sialylated as expressed on alpha-dystroglycan. We show that C2C12 alpha-dystroglycan bound to peanut agglutinin only after digestion with neuraminidase. Simultaneous treatment of myotubes with neuraminidase and endo-O-glycosidase diminished alpha-dystroglycan binding to peanut agglutinin and inhibited neuraminidase-induced AChR clustering. We conclude that sialylated core 1 oligosaccharides of alpha-dystroglycan are important for laminin-induced AChR clustering and that their function in this process is distinct from the established role of alpha-dystroglycan oligosaccharides in laminin binding.
Preparation of Pyrido-(2,3)-pyrazines, Pyrido-(3,4)-pyrazines and Imidazo-(b)-pyridines (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Pyrido-(2,3)-pyrazines, Pyrido-(3,4)-pyrazines and Imidazo-(b)-pyridinesMERVYN ISRAEL and ALLAN R. DAYCite this: J. Org. Chem. 1959, 24, 10, 1455–1460Publication Date (Print):October 1, 1959Publication History Published online1 May 2002Published inissue 1 October 1959https://pubs.acs.org/doi/10.1021/jo01092a018https://doi.org/10.1021/jo01092a018research-articleACS PublicationsRequest reuse permissionsArticle Views461Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optical imaging of bilingual cortical representations (2000)

The organization of language in the brains of multilingual persons remains controversial. The authors investigated language representations in a proficient bilingual patient by using a novel neuroimaging technique, intraoperative optical imaging of intrinsic signals (iOIS), and a visual object naming task. The results indicate that there are cortical areas that are activated by the use of both English and Spanish languages (superior temporal sulcus, superior and middle temporal gyri, and parts of the supramarginal gyrus). In addition, language-specific areas were identified in the supramarginal (Spanish) and precentral (English) gyri. These results suggest that cortical language representations in bilingual persons may consist of both overlapping and distinct components. Furthermore, this study demonstrates the utility of iOIS in detecting topographical segregation of cognitively distinct cortices.
Ordered cellular automata in one dimension (1993)

We study a probabilistic one-dimensional majority-rule two-state cellular automaton and examine the stability of ordered magnetised states in systems of size L as the neighbourhood radius R varies. We find that a scaling R ∼ln L is sufficient for an ordered phase to be metastable, i.e., to survive for times much longer than the typical critical fluctuation. The lattice magnetisation obeys a scaling relation which agrees with results from mean-field analysis.
ChemInform Abstract: METHYLENDIOXYHETARENE 2. MITT. REAKTIONEN DES 3,4‐METHYLENDIOXY‐2,5‐THIOPHENDICARBONSAEUREDIAETHYLESTERS (1975)

Abstract Die Hydrolyse des Diesters (Ia) mit methanolischer und äthanolischer Kalilauge gibt die Disäure (Ib), die mit CH2N2/Äther zu (Ic) verestert wird.
The occurrence of <i>Diplozoon paradoxum</i> Nordmann, 1832 (Trematoda: Monogenea) in certain waters of northern England and its distribution on the gills of certain Cyprinidae (1968)

The monogenean Diplozoon paradoxum occurs on Abramis brama, Gobio gobio, Phoxinus phoxinus and Rutilus rutilus in northern England. In any one area, the infection is present in some waters but absent in others and predominates in rivers rather than in ponds or reservoirs. D. paradoxum is randomly distributed on the gills, sides of the gill apparatus, hemibranchs and surfaces of primary lamellae of G. gobio, P. phoxinus and R. rutilus (except for P. phoxinus where inner hemibranchs carry more worms), but prevails on median sectors of the gills of these hosts. In A. brama the parasite is more numerous on certain gills, on the right side of the gill apparatus, and on the inner hemibranchs, but is randomly disposed on primary lamellar surfaces and along the gills. Except on G. gobio attachment is predominantly to two primary lamellae rather than one. This may reduce dislodging effects of the gill ventilating current by leaving portions of the lamellar surfaces unoccupied and allowing unimpeded flow in these regions. This work was conducted during tenure of a Science Research Council Research Studentship. Research facilities in the Department of Zoology, University of Leeds, were kindly provided by Professor J. M. Dodd. Other facilities in the Biological Station, St John's, Newfoundland, were provided by the Director, Dr W. Templeman. Statistical advice offered by Dr E. Broadhead, Department of Zoology, and Professor C. L. Oakley, Department of Bacteriology, both of the University of Leeds, is gratefully acknowledged. I am indebted to Dr R. Wynne Owen, Department of Zoology, for constant advice and encouragement and for critical reading of the manuscript.
Pulsed Nuclear Magnetic Resonance in Cesium Fluoride (1969)

Pulse nuclear-magnetic-resonance techniques have been used to obtain the free-induction-decay curves of both the ${\mathrm{F}}^{19}$ and ${\mathrm{Cs}}^{133}$ nuclear spin systems in single crystals of cesium fluoride. The experimental curves are compared with the theories of Gade and Lowe and of Lee, Tse, Goldburg, and Lowe. The ${\mathrm{F}}^{19}$ free induction decays can be satisfactorily described by considering only dipolar interactions among the nuclear spins. The ${\mathrm{Cs}}^{133}$ free induction decays are not in agreement with the predictions of dipolar theory. It is suggested that this departure is due to nuclear electric quadrupole effects.
Chronic Venous Insufficiency: Dysregulation of Collagen Synthesis (2003)

Varicose vein disease is a common condition. Its pathology is not well characterized. A disorganization of smooth muscle cells and extracellular matrix components in the venous wall have been described. The objective of this paper is to offer an explanation for the abnormal distensibility of varicose veins. The content of hydroxyproline was quantified in control and varicose human saphenous veins. The synthesis of collagen types I, III, and V was quantified in cultured venous smooth muscle cells and dermal fibroblasts of control subjects and patients with varicose veins. The proportion of collagen type III in the heterofibrils composed by collagen types I, III, and V was calculated. The level of hydroxyproline was increased in varicose veins, suggesting an increased content of collagen. This augmentation of collagen in diseased tissues appears to be correlated with an increase of collagen type I since the collagen I mRNA was overexpressed in varicose veins, whereas collagen type III mRNA was not altered. The quantification of collagen synthesis in cultured cells shows that proportion of collagen type III was significantly decreased in cultured smooth muscle cells and dermal fibroblasts derived from patients with varicose veins. The results indicate a deficiency in collagen type III in patients with varicose veins. Since collagen type III is involved in tissue elasticity, these results offer an explanation for the abnormal distensibility of varicose veins. Moreover, this defect seems to be generalized in different tissues and argues in favor of a genetic alteration of remodeling in these patients.
New Approach in Modeling of Metallocene‐Catalyzed Olefin Polymerization Using Artificial Neural Networks (2009)

Abstract A new approach for the estimation of kinetic rate constants in olefin polymerization using metallocene catalysts is presented. The polymerization rate has been modeled using the method of moments. An ANN has been used and trained to behave like the mathematical model developed before, so that it gets polymerization rate at different reaction times and predicts reaction rate constants. The network was trained using modeling results in desired operational window. The polymerization rates were normalized to make the network work independent of operational conditions. The model has also been applied to real polymerization rate data and the predictions were satisfactory. This model is specially useful in comparing different new metallocene catalysts. magnified image
ChemInform Abstract: A Convenient Triphosgene‐Mediated Synthesis of Symmetric Carboxylic Acid Anhydrides. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vorbemerkungen: Kulturrevolution und Zivilgesellschaft in Europa (1991)

Die „Konservative Revolution“1, eine antirepublikanische ideologische Strömung in der Weimarer Republik, gilt als Wegbereiter für rechtsextreme und faschistische Bewegungen. Die heutige „Neue Rechte“ liebäugelt nicht mit einem faschistischen Regime, sondern mit einer „Kulturrevolution von rechts“. Sie nimmt sich linke Theoretiker vor, wertet sie aus und erarbeitet Strategien, die für die Rechte durchaus unorthodox sind. Denn in den Kreisen der Alten Rechten herrschte Anti-Intellektualismus, eine Verachtung theoretischer Arbeit. Damit hat die Neue Rechte gründlich aufgeräumt. Hat sie ihr Ziel erreicht? Findet tatsächlich eine kulturelle Revolution2 statt? Und wenn: Kann sie als eine Revolution von rechts verortet werden? Auf welchen Gebieten konnten Erfolge erzielt werden? Existieren Querverbindungen zu rechtsextremen Gruppierungen und Parteien? Welchen Stellenwert haben diese Verbindungen?
ChemInform Abstract: Stereocontrolled Synthesis of Lissoclinolide by Sequential Transition Metal‐Catalyzed Lactonization/Cross‐Coupling Reactions. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Concordance of Intraoperative Left Ventricular Wall-motion Abnormalities and Electrocardiographic S-T Segment Changes  (1998)

Wall-motion abnormalities detected by TEE are more common than S-T segment changes detected by ECG, and concordance between the two modalities is low. One half of patients with MI had preceding ECG or TEE ischemia. Logistic regression revealed that TEE is twice as predictive as ECG in identifying patients who have MI.
BUM ROUNDS AT SAN FRANCISCO GENERAL HOSPITAL (1980)

The major burn victim can be a tremendous medical and psycho-social challenge. Adequate care requires a team approach to initiate acute management, prevent and treat complications, and rehabilitate the patient to a functional status. The basic guidelines for these areas are outlined, along with a means of auditing burn care. This review will attempt to highlight the current thought on the pathophysiology, management, and prevention of burns, and will describe the procedures we use in our hospital. A number of controversies still exist among experts in burn care, and we will try neither to avoid nor to solve these controversies.
Optical time-domain reflectometry interrogation of multiplexing low-reflectance Bragg-grating-based sensor system (2003)

Low-reflectance fiber Bragg gratings (FBGs) can be interro- gated in real time with a high-resolution optical time-domain reflectom- etry (OTDR) technology. The technique allows interrogation of a series of FBGs with the intensity change based on the OTDR pulse spectral char- acteristics and the FBG reflection. Experimental results are presented for multiplexing of dual-wavelength FBG sensors to produce referencing calibration in sensor measurement. With this structure, the influence of the source power fluctuations and fiber bend losses can be greatly re- duced. This scheme can be applied to the practical measurement of distributed temperature or strain. © 2003 Society of Photo-Optical Instrumentation Engineers. (DOI: 10.1117/1.1571061)
Characterization and Applications of Laser-Driven X-ray Lasers (2005)

Brief description of collisional excitation soft x-ray lasers.
Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression (1997)

The norepinephrine transporter (NET) is a membrane protein responsible for termination of the action of synaptic norepinephrine and is a site of action of many drugs used to treat major depression. The present study determined whether the binding of [3H]nisoxetine to the NET is altered in the locus coeruleus (LC) in major depression, using brain tissue collected postmortem from subjects diagnosed with major depression and from age-matched normal control subjects. Thirteen of the 15 major depressive subjects studied died by suicide. The distribution of [3H]nisoxetine binding along the rostro-caudal axis of the nucleus was uneven and was paralleled by a similar uneven distribution of neuromelanin-containing cells in both major depressives and psychiatrically normal control subjects. The binding of [3H]nisoxetine to NETs in the midcaudal portion of the LC from major depressive subjects was significantly lower than that from age-matched, normal control subjects. The binding of [3H]nisoxetine to NETs in other regions of the LC was similar in major depressives and control subjects. In contrast to reductions in binding to NETs, there were no significant differences in the number of noradrenergic cells at any particular level of the LC between major depressives and normal control subjects. The decreased binding of [3H]nisoxetine to NETs in the LC in major depression may reflect a compensatory downregulation of this transporter protein in response to an insufficient availability of its substrate (norepinephrine) at the synapse.
Spontaneous Water Imbibition into Diatomite (1998)

Abstract A systematic experimental investigation of capillary pressure characteristics and fluid flow in diatomite has begun. Using an X-ray CT scanner and a specially constructed imbibition cell, we study spontaneous water imbibition processes in diatomite and for reference Berea sandstone and chalk. The mass of water imbibed as a function of time is also measured. Imbibition is restricted to cocurrent flow. Despite a marked difference in rock properties including permeability and porosity, we find similar trends in saturation profiles and weight gain versus time functions. Imbibition in diatomite is relatively rapid when initial water saturation is low due to large capillary forces.
Eliminating Bias In Acousto-Optical Spectrum Analysis (1992)

Scheme for digital processing of video signals in acousto-optical spectrum analyzer provides real-time correction for signal-dependent spectral bias. Spectrum analyzer described in Two-Dimensional Acousto-Optical Spectrum Analyzer (NPO-18092), related apparatus described in Three-Dimensional Acousto-Optical Spectrum Analyzer (NPO-18122). Essence of correction is to average over digitized outputs of pixels in each CCD row and to subtract this from the digitized output of each pixel in row. Signal processed electro-optically with reference-function signals to form two-dimensional spectral image in CCD camera.
Principles of stationary phase selectivity in gas-liquid chromatography (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPrinciples of stationary phase selectivity in gas-liquid chromatographyStanley H. LangerCite this: Anal. Chem. 1967, 39, 4, 524–525Publication Date (Print):April 1, 1967Publication History Published online1 May 2002Published inissue 1 April 1967https://pubs.acs.org/doi/10.1021/ac60248a007https://doi.org/10.1021/ac60248a007research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Epitaxial Growth of Trichosanthin Protein Crystals on Mica Surface (2010)

We report the studies of epitaxial growth of trichosanthin (TCS) crystals on a mica substrate. TCS crystals grown on mica surface are found to be aligned well in four orientations, which was induced by the lattice of the mica substrate. The effect of potassium ions both at the mica surface and in solution was investigated by using different cation-modified surfaces and different precipitants. The results indicated that the binding of K+ ions on the mica surface played a critical role in the epitaxial crystal growth of TCS. The high-resolution structures of crystals grown in different precipitants were solved by synchrotron radiation X-ray crystallography, and the K+ binding sites in TCS crystals were identified. A strict lattice match between the TCS crystal and the mica substrate has been demonstrated based on the structural analysis of them. It reveals the mechanism of epitaxial nucleation and growth of TCS crystals. The experimental results provide new insights into the molecular mechanism of epitaxial growth and may open up the scope for the epitaxial crystal growth of proteins and other organic molecules.
15d-Prostaglandin J <sub>2</sub> Protects Brain From Ischemia-Reperfusion Injury (2005)

15d-PGJ2 suppressed ischemic brain infarction and neuronal apoptosis and necrosis in a PPARgamma dependent manner. 15d-PGJ2 may play a role in controlling acute brain damage induced by ischemia-reperfusion.
Effect of Fluorination on the Molecular Packing of Perfluoropentacene and Pentacene Ultrathin Films on Ag (111) (2010)

The growth of perfluoropentacene (PFP) and pentacene (PEN) ultrathin films on Ag(111) has been investigated using low-temperature scanning tunneling microscopy. To understand the influence that perfluorination of the parent molecule has on its resultant packing structure, the results are compared against each other in the framework of morphological differences. Perfluorination leads to a different packing structure in the first monolayer. We observed only one closely packed arrangement with periodic dislocation lines for PFP molecules, while for PEN molecules, there are two coexisting arrangements in the first monolayer. Monolayers of each molecule are commensurate with the underlying substrate with long axes of both molecules aligned in the [11̅0] direction along the silver surface. The disparity in arrangements is attributed to the difference in peripheral atoms of the two molecules. Additional photoemission spectroscopy studies reveal that PFP physisorbs on Ag (111).
Epitopes Predominantly Retained on the Carcinoembryonic Antigen Molecules in Plasma of Patients with Malignant Tumors but Not on Those in Plasma of Normal Individuals (1992)

We have previously reported that a group of monoclonal antibodies (MAbs) to carcinoembryonic antigen (CEA), designated Group F MAbs, are able to discriminate CEA in tumor tissues from normal fecal antigen-2, a soluble form CEA-counterpart in normal adult feces, and that the protein epitopes recognized by them are present on the domain A3-B3 of the CEA molecule. In this study, we further investigated the molecular localization of the epitopes recognized by the Group F MAbs using three new recombinant CEA proteins with restricted domain structures expressed in Chinese hamster ovary cells, and found that the epitopes for the Group F MAbs are present on domain B3 close to the anchoring device of the CEA molecule. The epitopes for the Group F MAbs were retained on the CEA molecules in the plasma of patients with malignant tumors and on the CEA molecules spontaneously released into the culture media from established tumor cell lines. However, a large part of the CEA molecules in the plasma of normal individuals were found to lack the epitopes for the Group F MAbs. These results provide a basis for the improved cancer diagnosis by using our CEA assay system utilizing a Group F MAb, and indicate the potential clinical utility of the Group F MAbs.