gebhart/patrepeval huggingface dataset:
Phencyclidine disposition after intravenous and oral doses (1982)

[3H]-Phencyclidine (PCP) hydrochloride was given in intravenous (0.1 or 1 mg) or oral (1 mg) doses to male subjects. After 1 mg IV, drug and metabolites were recovered in urine (72.8 +/- 4.0% of dose), feces (4.7 +/- 0.9%), and perspiration. Fecal excretion was low (3.4 +/- 0.4%) after oral dosing and oral bioavailability was estimated at 72%. PCP comprised 16% of urinary radioactivity with 31% consisting of enzymatically hydrolyzable conjugates of hydroxylated metabolites. Both cis and trans isomers of 4-phenyl-4-(1-piperidinyl)cyclohexanol were found. Maximum average plasma PCP concentrations of 2.7 to 2.9 ng/ml were observed after oral and intravenous 1-mg doses. Blood/plasma ratios were approximately 1.0 and plasma binding was about 65%. Parent drug was found in saliva. Apparent terminal phase half-lifes averaged 21 +/- 3 hr (harmonic mean 17 hr, range 7 to 46 hr). The volume of distribution averaged 6.2 +/- 0.3 l/kg. Renal clearances were variable, but the average was 9% of the total clearance. Thus, PCP is cleared principally by metabolism.
Outpatient Appointment Block Scheduling Under Patient Heterogeneity and Patient No‐Shows (2017)

We study outpatient appointment block scheduling policies for single providers under conditions of patient heterogeneity in service times and patient no‐shows. The objective is to find daily appointment schedules that minimize a weighted sum of patients’ waiting time, the physician's idle time, and the physician's overtime. We contribute by suggesting new effective sequential block scheduling procedures motivated by actual outpatient clinic practices across the globe and grounded in the successful Toyota Production System load smoothing approach. Our block scheduling policy first assigns a sequence of different patient types within a time block. The policy then allocates repetitive blocks across a planning horizon. We start our analysis by studying the case with zero probability of no‐shows. Under the setting that the physician's idle time is zero, we propose a polynomial time optimal scheduling approach for two patient types, before demonstrating that the problem with at least three patient types is NP‐Hard. Various extensions to incorporate practical outpatient clinic environment dimensions are considered. We then extend our scheduling approach to incorporate reasonable patient no‐show probabilities. Finally, our block scheduling approach is adapted for scenarios where outpatient clinics use an open‐access scheduling environment, where patients make same‐day appointments. We compare our block scheduling policies against extant scheduling policy, finding our block scheduling policies surpass the benchmark method.
ChemInform Abstract: The Hydridopentacyanocobaltate Anion‐Induced Deoxygenation of Allylic Alcohols Using β‐Cyclodextrin as a Phase Transfer Agent. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Solar Cells: Structural and Electronic Properties of Semiconductor‐Sensitized Solar‐Cell Interfaces (Adv. Funct. Mater. 24/2011) (2011)

On page 4663, Christopher E. Patrick and Feliciano Giustino investigate the interface between TiO2 and Sb2S3 found in semiconductor-sensitized solar cells by means of first principle calculations. An atomistic model of the TiO2 and Sb2S3 interface is proposed and the interfacial energy-level alignment and ideal open-circuit voltage are determined. The analysis of other isostructural sensitizers indicates that anti-monselite (Sb2Se3) holds potential for delivering higher energy conversion efficiencies than the TiO2/Sb2S3 system.
Gasförmige Hydroxide. V. Über ein gasförmiges Hydroxid des Vanadins (1963)

Abstract Im Temperaturbereich von 500650°C wird die Flüchtigkeit von V 2 O 5 in Gegenwart von Wasserdampf mit Hilfe der Mitführungsmethode untersucht. Nach den Meßergebnissen wird das vorliegende heterogene Gleichgewicht formuliert nach magnified image Die ermittelten thermodynamischen Daten werden mitgeteilt. V 2 O 3 (OH) 4(gas) muß als neue gasförmige Verbindung des Vanadins betrachtet werden.
Effect of supplementary implantation of a sulcus-fixated intraocular lens in patients with negative dysphotopsia (2018)

Of all individual biometry results, only angle κ showed a relationship with the course of negative dysphotopsia. In patient-specific optical modeling of sulcus-fixated IOL implantation, the increase in simulated light irradiance at the periphery was related to the course of negative dysphotopsia.
Separation of Reliability and Secrecy in Rate-Limited Secret-Key\n Generation (2012)

For a discrete or a continuous source model, we study the problem of\nsecret-key generation with one round of rate-limited public communication\nbetween two legitimate users. Although we do not provide new bounds on the\nwiretap secret-key (WSK) capacity for the discrete source model, we use an\nalternative achievability scheme that may be useful for practical applications.\nAs a side result, we conveniently extend known bounds to the case of a\ncontinuous source model. Specifically, we consider a sequential key-generation\nstrategy, that implements a rate-limited reconciliation step to handle\nreliability, followed by a privacy amplification step performed with extractors\nto handle secrecy. We prove that such a sequential strategy achieves the best\nknown bounds for the rate-limited WSK capacity (under the assumption of\ndegraded sources in the case of two-way communication). However, we show that,\nunlike the case of rate-unlimited public communication, achieving the\nreconciliation capacity in a sequential strategy does not necessarily lead to\nachieving the best known bounds for the WSK capacity. Consequently, reliability\nand secrecy can be treated successively but not independently, thereby\nexhibiting a limitation of sequential strategies for rate-limited public\ncommunication. Nevertheless, we provide scenarios for which reliability and\nsecrecy can be treated successively and independently, such as the two-way\nrate-limited SK capacity, the one-way rate-limited WSK capacity for degraded\nbinary symmetric sources, and the one-way rate-limited WSK capacity for\nGaussian degraded sources.\n
Brown Dwarf Kinematics Project (BDKP) (2007)

Abstract We report on the progress of the Brown Dwarf Kinematics Project (BDKP), which aims to measure the 6D positions and velocities of all known brown dwarfs within 20 pc of the Sun and select sources of scientific interest. In this paper we report on the status of the 33 targets on our parallax list as well as the results of our proper motion survey where we have measured over 400 new proper motions for known late M, L and T dwarfs.
BLASTAssemb: An approach to construct genetic elements using BLAST (2014)

With the availability of recent next generation sequencing technologies and cheap price, genome of different organisms is now being sequenced frequently. Therefore, quick assembling of a genetic element from the raw genome generated through the sequencing technologies has become necessary for better understanding of different biological systems. This paper proposes an algorithm for constructing genetic elements from raw genome using reference sequences. For this, we considered a weighted frequency based consensus making mechanism. Furthermore, we have used BLAST (Basic local alignment search tool), a well known tool to the community of bioinformaticians, in this regard. The proposed method, thus applies the capability of BLAST, which enables the construction of genetic elements from raw sequences. For evaluating our algorithm, we have chosen Pokkali (a verity of rice) raw genome and few promoters of Japonica (another verity of rice) as our reference data. Experimental results demonstrated that our proposed algorithm could accurately construct the promoter sequences of Pokkali from its raw genome sequences.
[Diagnostic and therapeutic use of monoclonal antibodies]. (1985)

During the last years monoclonal antibodies have become an important constituent of the clinical diagnostic systems for the detection of various humoral and cellular antigens. By means of monoclonal antibodies new knowledge could be observed in the typing of leukaemias and in the functional characterization of immune cells. Furthermore, possibilities of therapeutical use of monoclonal antibodies and present problems concerning this matter are discussed. The development of human monoclonal antibodies will be helpful in the solution of some of these problems.
Chip embedding technology for power applications (2010)

During the past decade embedding of semiconductor chips into printed circuit board structures evolved from a research topic to volume production. The paper will briefly describe this development and categorise today's embedding technologies. First modules with embedded chips are in production in Asia, mainly for telecom and computer applications. In Europe embedding has gained a strong interest for power modules, especially in automotive applications. Main drivers are the capability for compact and thin packaging, the high reliability and cost saving potential. In a number of European cooperation projects with partners from industry and research, embedding of power chips, like IGBTS and power MOSFET, is pushed. In this paper current achievements of these projects will be shown, especially examples of realised devices and their characteristics. The dominating technology for power chip embedding is a face-up technology. Chips are bonded with their backside (drain contact) to a Cu substrate using highly conductive adhesive or solder. Then Chips are embedded by vacuum lamination of prepreg or RCC (resin coated copper) layers. Via holes to the top contacts (gate and source) are formed by laser drilling. The vias are metallised using conventional Cu plating. Finally conductor structures are etched in the top Cu layer, finalising the circuit. Details will be given about device manufacturing, related yield issues and strategies to overcome them. Finally scenarios for the implementation of embedding technology and concepts for future applications will be discussed.
Charakterisierung Heparin-beschichteter Titandioxide mittels Raman-Spektroskopie und Zeta-Potenzial (2003)

Raman-Spektroskopie Die Funktionalisierungen von Titandioxid-Oberflächen mit Heparin wurde hier vorgenommen. Die kovalente Bindung des Wirkstoffs erfolgte mit Hilfe des Haftvermittlers 3-Aminopropyltrimethoxysilan. Die funktionalisierten Oberflächen wurden durch Raman-und FT-IR-Spektroskopie hinsichtlich ihrer Zusammensetzung und durch Messung des Zeta-Potenzials im Hinblick auf die Oberflächenladung bei Kontakt mit wässrigem Elektrolyten charakterisiert. Die kovalente Bindung des Wirkstoffs konnte schwingungsspektroskopisch über das Auftreten symmetrischer SO,-Valenzschwingungen im Molekül nachgewiesen werden. Mit Hilfe des Zeta-Potenzials konnte der Schichtaufbau qualitativ im wässrigen Medium verfolgt werden, da die Zeta-Potenziale der aufgebrachten Schichten stark variieren. Durch den Haftvermittler wird das Potenzial der unmodifizierten Anatas-Oberfläche (ca. -30mV) in den positven Bereich verschoben (+40mV), bedingt durch das Vorhandensein protonierter Aminogruppen. Die kovalente Anbindung von Heparin resultiert in einer stark negativ geladenen Oberfläche mit einem Zeta-Potenzial von zirka -50 mV
Cardiovascular Gene Expression Profiles of Dioxin Exposure in Zebrafish Embryos (2005)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that causes altered heart morphology, circulatory impairment, edema, hemorrhage, and early life stage mortality in fish. TCDD toxicity is dependent, in large part, on the aryl hydrocarbon receptor (AHR), but understanding of the molecular mechanism of cardiovascular embryotoxicity remains incomplete. To identify genes potentially involved in cardiovascular effects, we constructed custom cDNA microarrays consisting of 4896 zebrafish adult heart cDNA clones and over 200 genes with known developmental, toxicological and housekeeping roles. Gene expression profiles were obtained for 3-day-old zebrafish after early embryonic exposure to either 0.5 or 5.0 nM TCDD. In all, 516 clones were significantly differentially expressed (p < 0.005) under at least one treatment condition; 123 high-priority clones were selected for further investigation. Cytochromes P450 1A and 1B1, and other members of the AHR gene battery, were strongly and dose-dependently induced by TCDD. Importantly, altered expression of cardiac sarcomere components, including cardiac troponin T2 and multiple myosin isoforms, was consistent with the hypothesis that TCDD causes dilated cardiomyopathy. Observed increases in expression levels of mitochondrial energy transfer genes also may be related to cardiomyopathy. Other TCDD-responsive genes included fatty acid and steroid metabolism enzymes, ribosomal and signal-transduction proteins, and 18 expressed sequence tags (ESTs) with no known protein homologs. As the first broad-scale study of TCDD-modulated gene expression in a non-mammalian system, this work provides an important perspective on mechanisms of TCDD toxicity.
Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide (2014)

These findings suggest that targeting both Hsp90 and Hsp70 with Antp-TPR and Hsp70-targeted peptide is an attractive approach for selective cancer cell killing that might provide potent and selective therapeutic options for the treatment of cancer.
Bond Orbitals and Bond Energy in Elementary Phosphorus (1952)

A discussion of the relative stability of the P4 molecule and black phosphorus is carried out, with use of hybrid spd bond orbitals. The amount of strain in the P4 molecule, in which the bond angles are 60°, is calculated to be 22.8 kcal mole−1. This value is shown to be compatible with thermochemical data; it corresponds to the value 51.3 kcal mole−1 for the bond energy of the normal P–P bond. A structure is proposed for red phosphorus and other allotropic forms of the element, and some of their properties are discussed in relation to their structure.
Taste sensor: The pharmaceutical taste analyser (2009)

Taste sensor is an intelligent electronic cum biophysical device that could be explored to artificially reproduce the sense of taste, which is otherwise a complex, comprehensive sense of man. Several kinds of foodstuffs, mineral waters and pharmaceutical formulations could be discriminated/differentiated easily using the taste sensor. Different electric potentials generated by chemical substances after interaction with the lipid/polymer membrane of the taste sensor is the basis of taste discrimination by the sensor. Hence, the taste sensors can be considered as a valuable tool in the evolution of bitterness intensity in function of time, which is essential in the selection of an optimal formulation. In the present study we have tried to explain the theory, composition and functioning of a taste sensor along with the potential applications of the same.
The Yield Stress for an Electrorheological Fluid in Squeeze (2001)

Abstract This paper is concerned with an experimental and theoretical determination of the rheological performance of an electrorhcological (ER) fluid when subjected to time-dependent applied loads. The experimental facility was built as a squeeze cell in which the fluid is sandwiched between two electrodes, one fixed and the other moving, which permits the instantaneous measurement of the mechanical and electrical responses of the fluid. The transient rheological characteristics of the fluid were assessed for various mechanical force levels and for constant voltage excitation of the fluid. Input and output stress levels across the fluid were monitored enabling the dynamic response of the fluid to be determined using a combination of displacement, force, velocity and acceleration transducers. The experimental results were compared with the results from a modified theoretical analysis, which employs a bi-viscous shear stress/shear strain characteristic of the electrically stressed fluid together with a fluid yield stress, which has a strain-direction dependence on the electrical field.
Flexible-length Fast Fourier Transform for COFDM (2008)

Integrated circuits to support digital communication standards are commonly based on a Fast Fourier Transform (FFT) of some length. Flexible length makes the design more usable for configurable algorithm-specific circuits. The paper disc uses the algorithmic, functional and structural aspects of a FFT design that can be configured from 16 to 8 k points by factors of 2. Fabricated in a 0.13 mum CMOS process technology, it runs with 160 MHz clock at 17.6 mWatt.
Somatostatin and Analogues in the Treatment of Cancer (1991)

Somatostatin is a naturally occurring cyclic tetradecapeptide that inhibits release of growth hormone and all gastrointestinal hormones. The beneficial effect of somatostatin in the treatment of certain hypersecretory disorders of hormone excess in well recognized; however its clinical usefulness has been limited in the past by its extremely short plasma half-life. The development of long-acting somatostatin analogues has provided clinically useful agents for treatment of hormone-producing tumors. In addition to well-known inhibiting effects on hormone release and actions, recent studies using experimental tumor models have demonstrated an antiproliferative effect of somatostatin and its analogues on growth of a variety of neoplasms. The exact role of somatostatin analogues in cancer therapy has yet to be established; however studies suggest that these agents could provide a useful and relatively nontoxic adjuvant therapy in the treatment of certain tumors. In this review, the oncologic application of somatostatin and possible mechanism of action are examined and current clinical and experimental studies are summarized.
Model Systems in Signal Transduction (1993)

In this volume, distinguished investigators discuss their research on intracellular signal transduction in microorganisms. The findings presented aim to shed new light on fundamental processes of cell regulation in complex as well as simple organisms.
3‐Hydroxyazetidine Carboxylic Acids: Non‐Proteinogenic Amino Acids for Medicinal Chemists (2013)

The formation from D-glucose of both enantiomers of 2,4-dideoxy-2,4-iminoribonic acid is the first chemical synthesis of unprotected 3-hydroxyazetidine carboxylic acids. The long-term stability of 3-hydroxyazetidine amides is established at acidic and neutral pH and implies their value as non-proteinogenic amino acid components of peptides, providing medicinal chemists with a new class of peptide isosteres. The structure of N,3-O-dibenzyl-2,4-dideoxy-2,4-imino-D-ribonic acid was established by X-ray crystallographic analysis. An N-methylazetidine amide derivative is a specific inhibitor of β-hexosaminidases at the micromolar level, and is only the second example of potent inhibition of any glycosidase by an amide of a sugar amino acid related to an iminosugar.
Segment level improvements in a preliminary female text-to-speech system (2009)

Some experiments to improve the naturalness of synthetic female speech will be presented. Synthesis improvements have been made mainly on the segmental level by including voice source variations and more complex articulation modelling. Source, formant and pole/zero parameter data generated by inverse filtering have been interpreted and incorporated into the female text-to-speech rule system. In particular, the quality of consonants with complex articulations and vowel-consonant transitions is enhanced. A diagnostic intelligibility test was performed on the preliminaiy rule system. Results will be discussed in terms of error sources and possible solutions. On-going work includes fine-tuning ofLF-source and pole/zero parameter control, based on these results.
History of tomotherapy (2006)

Tomotherapy is the delivery of intensity modulated radiation therapy using rotational delivery of a fan beam in the manner of a CT scanner. In helical tomotherapy the couch and gantry are in continuous motion akin to a helical CT scanner. Helical tomotherapy is inherently capable of acquiring CT images of the patient in treatment position and using this information for image guidance. This review documents technological advancements of the field concentrating on the conceptual beginnings through to its first clinical implementation. The history of helical tomotherapy is also a story of technology migration from academic research to a university-industrial partnership, and finally to commercialization and widespread clinical use.
Inherent Decorrelating and Least Perturbation Properties of the Normalized Subband Adaptive Filter (2006)

This correspondence describes and analyzes a class of subband adaptive filters (SAFs) that stems from various approaches of applying subband and multirate techniques in adaptive filtering. This class of SAFs, called the normalized SAF (NSAF), has a unique weight-control mechanism, whereby subband error signals are used to adapt a fullband tap-weight vector. In this correspondence, we elaborate on the inherent decorrelating properties of the NSAF, which manifest themselves in different forms as integral elements of the weight-control mechanism. We also show that the NSAF possesses some least perturbation properties that are also found in the normalized least-mean-square (NLMS) and affine projection (AP) algorithms
Ultrasonic Imaging, a Potential Tool for Sex Determination of Live Fish (1983)

Using two conventional, medical, ultrasound imaging systems, we studied 15 juvenile and 5 mature coho salmon (Oncorhynchus kisutch) to determine if their sex could be ascertained from ultrasound images. Although liver, gut, and skeletal structures were discernible, we found the ovary and testes of the juvenile salmon difficult to identify. In mature salmon (less than 1 month from spawning), the eggs, testes, and even the male gonadal duct were clearly visible. The present study provides the first report of a technique for rapid, less-than-60-second, non-invasive identification of the sex of salmon. Our findings indicate that rapid sex determination of live fish with ultrasound is feasible.
Biomechanical Characteristics of Preactivation and Pulling Phases of Snatch Lift (1995)

The biomechanical characteristics of 13 snatch lifts performed by 4 elite athletes were analyzed. Electromyographic data, ground reaction force index (GRFI), knee angular velocities, barbell velocities, and lifting time were obtained 0.2 s before the lift, for the first pulling phase (FP), and for the second pulling phase (SP). The preactivation, normalized electromyographic values correlated negatively with GRFI ( p < .01). In the FP and SP, all of the parameters correlated positively with each other except lifting time. GRFI in the FP also correlated positively with GRFI, maximum knee angular velocities, and maximum barbell velocities of the SP ( p < .01). In the SP, the ground reaction force reached its maximum first, followed by knee angular velocity and then barbell velocity. Barbell velocity reached its maximum before the knee and the hip joint were fully extended. When the correlation of parameters between the consecutive phases of snatch weight lifting was analyzed, it was demonstrated that the preactivation of trunk and leg muscles is important in the activation of the reflectory system in order to fully utilize the forces for generating lifting speed in the pulling phase.