gebhart/patrepeval huggingface dataset:
Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats (2008)

Visceral inflammation, including that arising from bladder inflammation, reduces the threshold to sensation of innocuous or noxious stimuli applied to peripheral structures (referred hyperalgesia). Cystitis may induce transient or persistent plastic changes mediated by neurotrophins, particularly nerve growth factor (NGF), which contribute to increased nociceptive input. In this study, acute or subacute cystitis was induced in female rats by one or three (at 72-h intervals) 400-microl intravesical instillations of 1 mM acrolein. Sensitivity of the hindpaws to mechanical and thermal stimuli was determined before and 4, 24, 48, 72, and 96 h after treatment. Other groups of rats were treated with intravesical or intrathecal k252a [a nonspecific antagonist of tyrosine kinase (trk) receptors, including trkA, the high-affinity receptor for NGF] before the first or third acrolein instillation. Some rats were intraperitoneally injected with specific NGF-neutralizing antiserum or normal serum before acrolein instillation. Acute and subacute cystitis induced mechanical, but not thermal, referred hyperalgesia that was attenuated by intravesical pretreatment with k252a. Systemic treatment with NGF-neutralizing antiserum before instillation of acrolein suppressed subsequent mechanical referred hyperalgesia. Expression of NGF was increased within the bladder by acute or subacute cystitis and in L6/S1 dorsal root ganglia by subacute cystitis. These results suggest that the bladder-derived NGF acting via trk receptors at least partially mediates peripheral sensitization to mechanical stimuli associated with acute and subacute acrolein-induced cystitis.
Biocompatibility and genotoxicity studies of polyallylamine hydrochloride nanocapsules in rats (2014)

PAH nanocapsule studies in rats showed that it is biocompatible and nongenotoxic for further<italic>in vivo</italic>drug-delivery studies.
Electron Attachment and Compound Formation in Flames. III. Negative Ion and Compound Formation in Flames Containing Tungsten and Potassium (1970)

Application of several different experimental techniques (flame-ion mass spectrometry, microwave cavity resonance, electrostatic probe, and absorption spectrophotometry) reveals that addition of tungsten to fuel-rich atmospheric-pressure H2/O2/N2 flames seeded with potassium results in reductions in concentrations of free potassium atoms and in formation of stable W-containing negative ions. The following reaction scheme and enthalpy changes provide a satisfactory quantitative interpretation of the experimental results: K+H2WO4⇆KHWO4+H; ΔH0° = − 40 ± 40 kJ mol−1, H2WO4+e−⇆HWO4−+H; ΔH0° = + 40 ± 40 kJ mol−1, HWO4−+H⇆WO3−+H2O; ΔH0° = − 22 ± 40 kJ mol−1. The enthalpy changes imply electron affinities for WO3 and HWO4 of approximately 351 and 420 kJ mol−1, respectively.
Profiling direct mRNA-microRNA interactions using synthetic biotinylated microRNA-duplexes (2014)

MicroRNAs (miRNAs) are predominantly negative regulators of gene expression that act through the RNA-induced Silencing Complex (RISC) to suppress the translation of protein coding mRNAs. Despite intense study of these regulatory molecules, the specific molecular functions of most miRNAs remain unknown, largely due to the challenge of accurately identifying miRNA targets. Reporter gene assays can determine direct interactions, but are laborious and do not scale to genome-wide screens. Genomic scale methods such as HITS-CLIP do not preserve the direct interactions, and rely on computationally derived predictions of interactions that are plagued by high false positive rates. Here we describe a protocol for the isolation of direct targets of a mature miRNA, using synthetic biotinylated miRNA duplexes. This approach allows sensitive and specific detection of miRNA-mRNA interactions, isolating high quality mRNA suitable for analysis by microarray or RNAseq.
A Fast Fault-Tolerant Architecture for Sauvola Local Image Thresholding Algorithm Using Stochastic Computing (2015)

Binarization plays an important role in document image processing, particularly in degraded document images. Among all local image thresholding algorithms, Sauvola has excellent binarization performance for degraded document images. However, this algorithm is computationally intensive and sensitive to the noises from the internal computational circuits. In this paper, we present a stochastic implementation of Sauvola algorithm. Our experimental results show that the stochastic implementation of Sauvola needs much less time and area and can tolerate more faults, while consuming less power in comparison with its conventional implementation.
Microwave-assisted synthesis of new fluorinated coumarin–pyrimidine hybrids as potent anticancer agents, their DNA cleavage and X-ray crystal studies (2015)

Rapid and high yielding synthesis of new fluorinated coumarin–pyrimidine hybrids and their application as potent anticancer agents is described.
Unusual type of adsorption isotherm describing capillary condensation without hysteresis (1993)

Adsorption isotherms of cyclopentane and nitrogen on a new porous crystalline aluminosilicate from the family MCM-41 are characterized by the volume filling of channels by capillary condensation without hysteresis, which commences in the region prior to the lower closure point at the hysteresis loop.
Web application firewall using character-level convolutional neural network (2018)

Web applications can be maliciously exploited by malicious HTTP requests. Normally, web application firewall (WAF) protects web applications from known attacks using pattern matching method. However, introduction of WAF is usually expensive as it requires the definition of patterns according to the situation. Furthermore, the system cannot block unknown malicious request. In this paper, we come up with an efficient machine learning approach to solve these issues. Our approach uses Character-level convolutional neural network (CLCNN) with very large global max-pooling for extracting the feature of HTTP request and identify it into normal or malicious request. We evaluated our system on HTTP DATASET CSIC 2010 dataset and achieved 98.8% of accuracy under 10-fold cross validation and the average processing time per request was 2.35ms.
Unusual lesion morphology and skin test reaction for Mycobacterium avium complex in macaques. (1988)

Three rhesus (Macaca mulatta) and one cynomolgus (M. fascicularis) monkey were euthanized because of positive reactions to intradermal tests with mammalian Old Tuberculin (mOT). All the animals had gross or microscopic lesions consisting of unitized macro- or microgranulomas with central necrosis, involving the lung or mesenteric lymph nodes. Small numbers of acid fast organisms were demonstrated in the lesions. Mycobacterium avium complex, serotype 2 was isolated from three of the cases. The cases were unusual because the lesion morphology and mOT hypersensitivity were more typical of mammalian tuberculosis than avian tuberculosis in monkeys.
Management of herpes zoster (shingles) and postherpetic neuralgia (2004)

Herpes zoster (HZ) results from recrudescence of varicella zoster virus latent since primary infection (varicella). The overall incidence of HZ is approximately 3/1000 of the population per year rising to 10/1000 per year by 80 years of age. Approximately 50% of individuals reaching 90 years of age will have had HZ. In approximately 6%, a second attack may occur (usually several decades after the first). Patients with HZ can transmit the virus to a non-immune individual causing varicella. HZ is not contracted from individuals with varicella or HZ. Reduced cell-mediated immunity to HZ occurs with ageing, explaining the increased incidence in the elderly and from other causes such as tumours, HIV and immunosuppressant drugs. Diagnosis is usually clinical from typical unilateral dermatomal pain and rash. Prodromal symptoms, pain, itching and malaise, are common. The most common complication of HZ is postherpetic neuralgia (PHN), defined as significant pain or dysaesthesia present >or= 3 months after HZ. PHN results from damage and secondary changes within components of the nervous system subserving pain. Some motor deficit is common; severe and long-lasting paresis may rarely accompany HZ. More than 5% of elderly patients have PHN at 1 year after acute HZ. Predictors of PHN are, greater age, acute pain and rash severity, prodromal pain, the presence of virus in peripheral blood as well as adverse psychosocial factors. Therapy for acute HZ is intended to reduce acute pain, hasten rash healing and reduce the risk of PHN and other complications. Antiviral drugs are close to achieving these aims but do not entirely remove risk of PHN. Oral steroids show no protective effect against PHN. Adequate analgesia during the acute phase may require strong opioid drugs. Nerve blocks and tricyclic antidepressants (TCAs) may reduce the risk of PHN although firm evidence is lacking. PHN requires thorough evaluation and development of a management strategy for each individual patient. Initial therapy is with TCAs (e.g., nortriptyline) or the anticonvulsant gabapentin. Topical lidocaine patches frequently reduce allodynia. Strong opioids are sometimes required. Topical capsaicin cream is beneficial for a small proportion of patients but is poorly tolerated. NMDA antagonists have not proved beneficial with the exception of ketamine. Transcutaneous Electrical Nerve Stimulation (TENS) may be effective in some cases. HZ is a common condition. Severe complications such as stroke, encephalitis and myelitis are relatively rare whereas sight threatening complications of ophthalmic HZ are more common. PHN is common, distressing and often intractable. Good management improves outcome.
Human Performance Modeling in Aviation (2007)

Based on the six-year NASA Aviation Safety and Security Program Human Performance Modeling project, a collaboration of five teams from industry and academia, Human Performance Modeling in Aviation chronicles the results of modeling NASA-supplied data on two aviation flight deck problems: pilot surface operations taxi errors, and approach and
Fault Diagnosis of MOS Combinational Networks (1982)

The increasing difficulties in testing large logic networks have generated the need for designing logic networks for testability. Computer algorithms for designing diagnosable metal oxide semiconductor (MOS) networks with and without fan-in, fan-out constraints were described in previous papers by the authors. In this two-part series, we discuss the testing of these designed networks.
Study of blind detection techniques in adaptive OFDM (2006)

A blind detection algorithm based on Higher-order cumulants(HOC) is proposed to detect the modulation scheme for the OFDM subcarriers.Its detection feature is robust to the Gaussian noise and is invariant with respect to the attenuation and the phase rotation induced by subchannels.The invariant property is theorectically proved.The high performance and robustness of the blind detection algorithms are proved by simulation.
Object-oriented design of radar warning receiver application software (2002)

Describes an object-oriented approach that is being used to design Ada application software for an airborne radar warning receiver program. The objective is software that can be rapidly reprogrammed by merely changing the database that contains emitter descriptions, instead of changing any code. In addition, the hardware/software interfaces are encapsulated to make it possible to deploy the system on several types of aircraft with differing subsystem configurations without changing the software. Interface encapsulation also facilitates concurrent engineering, of the hardware and software. Tradeoffs and lessons learned in applying object-oriented design to achieve these objectives in a real-time application with low latency requirements are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reduced Expression of P2Y<sub>1</sub>Receptors in Connexin43-Null Mice Alters Calcium Signaling and Migration of Neural Progenitor Cells (2003)

Glial calcium signals play important roles during CNS development. Calcium transients induced by ATP, acting on purinergic receptors, stimulate DNA synthesis, increase astrocytic and neural stem cell proliferation, and are prominent during the differentiation of radial glia. We have shown previously that expression of P2Y receptors in astrocytes is altered when connexin43 (Cx43) is downregulated. To evaluate the consequences of Cx43 deletion on calcium signaling during neural progenitor development, studies were performed on neurospheres derived from embryonic striatum. After adhesion, cells migrating from wild-type (WT) and Cx43-null neurospheres displayed spontaneous calcium oscillations. Such activity was blunted by apyrase, 2'-deoxy-N6-methyladenosine 3',5'-bisphosphate (MRS-2179), and suramin, suggesting that ATP released by neural cells acts on purinergic receptors to induce calcium oscillations. The amplitudes of Ca2+ transients induced by P2Y but not P2X receptor agonists were larger in WT than in Cx43-null progenitors, suggesting that these two cell populations express different P2 receptors. Suramin, a nonselective P2 receptor antagonist, and MRS-2179, a P2Y1 receptor-selective antagonist, reduced the proliferation rate and the migration of WT progenitor cells to levels similar to those of Cx43-null cells. Conversely, exogenous expression of P2Y1 receptors in Cx43-null cells restored their migration pattern to levels seen in WT progenitors. However, treatment with P2 receptor antagonists did not alter the ratio of nestin to GFAP expression in WT neural progenitors. These data show that altered autocrine-paracrine communication attributable to reduced levels of P2Y1 receptors in neural progenitor cells lacking Cx43 affects proliferation and migration but not cell differentiation during early CNS development.
The plasma display - A digitally controllable, high brightness display with an inherent memory (1968)

Characteristics of digital controllable high brightness plasma display for airborne systems
Co-expression and impact of prostate specific membrane antigen and prostate specific antigen in prostatic pathologies (2010)

These data suggest that these markers are regulated differentially and the difference in their expression showed a correlation with malignant transformation. With regard to the duality PSMA-PSA, this implies the significance of their investigation together in normal and pathologic prostate tissues.
Pathogenesis of diabetic nephropathy: focus on transforming growth factor-β and connective tissue growth factor (2001)

Although considerable improvement in the prognosis of diabetic nephropathy has been achieved in recent years due to intensive insulin and angiotensin-converting enzyme inhibitor treatment, these approaches do not provide complete protection against progression of diabetic nephropathy. An urgent need for additional novel therapies to prevent or further slow the progression of diabetic nephropathy motivated us to provide an up-to-date review with particular emphasis on the potential role of two growth factors--transforming growth factor-beta and connective tissue growth factor--in the pathogenesis of diabetic nephropathy. The most intensively studied to date, transforming growth factor-beta appears to play a central role in the pathogenesis of diabetic nephropathy. Recently, attention has focused on connective tissue growth factor, which mimics the biological activity of transforming growth factor-beta in profibrotic tissue formation. Thus, acting as a downstream mediator of the profibrotic activity of transforming growth factor-beta, connective tissue growth factor may constitute a more specific target for future antifibrotic therapies.
Functional association of retinoic acid and <i>hedgehog</i> signaling in <i>Xenopus</i> primary neurogenesis (1999)

Previous work has shown that the posteriorising agent retinoic acid can accelerate anterior neuronal differentiation in Xenopus laevis embryos (Papalopulu, N. and Kintner, C. (1996) Development 122, 3409-3418). To elucidate the role of retinoic acid in the primary neurogenesis cascade, we investigated whether retinoic acid treatment of whole embryos could change the spatial expression of a set of genes known to be involved in neurogenesis. We show that retinoic acid expands the N-tubulin, X-ngnr-1, X-MyT1, X-&Dgr;-1 and Gli3 domains and inhibits the expression of Zic2 and sonic hedgehog in the neural ectoderm, whereas a retinoid antagonist produces opposite changes. In contrast, sonic and banded hedgehog overexpression reduced the N-tubulin stripes, enlarged the neural plate at the expense of the neural crest, downregulated Gli3 and upregulated Zic2. Thus, retinoic acid and hedgehog signaling have opposite effects on the prepattern genes Gli3 and Zic2 and on other genes acting downstream in the neurogenesis cascade. In addition, retinoic acid cannot rescue the inhibitory effect of Notch(ICD), Zic2 or sonic hedgehog on primary neurogenesis. Our results suggest that retinoic acid acts very early, upstream of sonic hedgehog, and we propose a model for regulation of differentiation and proliferation in the neural plate, showing that retinoic acid might be activating primary neurogenesis by repressing sonic hedgehog expression.
Isomers of Poly Aminophenol: Chemical Synthesis, Characterization, and Its Corrosion Protection Aspect on Mild Steel in 1 M HCl (2014)

The oxidative chemical polymerizations of three isomers of aminophenol, ortho , meta , and para (PoAP, PmAP, and PpAP), were performed in aqueous HCl using ammonium persulfate as an oxidant at 0–3°C. The synthesized polymers were characterized by employing elemental analysis, GPC, UV-VIS-NIR, FT-IR, XRD, and TGA. The corrosion inhibition effect of these three polymers on mild steel in 1 M HCl solution was studied by using electrochemical techniques such as potentiodynamic polarization and electrochemical impedance spectroscopy. These measurements reveal that the inhibition efficiency obtained by these polymers increased by increasing their concentration. The inhibition efficiency follows the order PpAP > PoAP > PmAP. The results further revealed that PpAP at a concentration of 250 mg/L furnishes maximum inhibition efficiency (96.5%). Polarization studies indicated that these three polymers act as the mixed type corrosion inhibitors.
Carbon Coated Helical Carbon Nanotubes used as Anode Materials of Li-ion Battery (2011)

The helical carbon nanotubes(HCNTs) was modified with carbon through thermal vapor deposition(TVD) of benzene at 900 ℃,and characterized by X-ray powder diffraction,transmission electronic microscope,scanning electronic microscope and Brunau-Emmertt-Teller method.The specific surface area of the HCNTs de-creased after carbon coating.The obtained carbon coated HCNTs used as anode materials of Li-ion battery were studied.The results revealed that appropriate amount of carbon coating could improve the first columbic efficiency,the cycling stability and rate charge/discharge performance of the HCNTs.After 45 min carbon coating,HCNTs gained a weight increase approximately 220wt%,with its first columbic efficiency increasing from 59.2% to 77.8%,and delivered a discharge capacity of 265.6,245.7,196.0,163.2 mAh/g at the rates of 1.0C,2.0C,5.0C and 10.0C,respectively.After 95 cycles at 10.0C,its discharge capacity retention was 93.3%.Although excessive carbon coat-ing could further improve the first coulumbic efficiency and cycling stability of HCNTs,it also degraded the rate capability.
A stretchable temperature sensor based on elastically buckled thin film devices on elastomeric substrates (2009)

Stretchable electronics and sensors have been attracting significant attention due to their unique characteristics and wide applications. This letter presents a prototype of a fully stretchable temperature sensor on an elastomeric substrate. The sensor was fabricated on a silicon-on-insulator wafer and then transferred to a prestrained elastomeric polydimethylsiloxane substrate. Releasing the prestrain on the substrates led to the formation of the microscale, periodic, wavy geometries of the sensor. The thin wavy sensor device can be reversibly bent and stretched up to 30% strain without any damage or performance degradation. A theoretical analysis was also developed to estimate the wavy profile.
Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study (2011)

sRAGE is significantly lower in patients with COPD than in age- and sex-matched individuals without airflow obstruction. Emphysema and chronic cor pulmonale are independent predictors of reduced sRAGE in COPD.
Growth of Large Single Crystals of Black Phosphorus under High Pressure (1982)

A large volume high pressure apparatus has made it possible to grow large single crystals of black phosphorus, P. After converting red P powder into black P under a high pressure of 10 kbar at high temperature, a melt of polycrystalline black P has been gradually solidified to bring about the growth of single crystals. Crystal sizes larger than 5×5×10 mm 3 are, for the first time, adequate for various measurements of the physical properties expected for this narrow gap semiconductor with a special layered structure. An X-ray analysis has proved the good single crystalline structure.
Review of NAND Flash Information Erasure Based on Overwrite Technology (2020)

The lack or incorrect implementation of storage device privacy and secret-related information erasure methods will cause serious security risks for personal privacy and national construction security. Although information erasure based on overwrite for magnetic storage media is relatively mature, it is difficult for these mature technologies to be directly used in the currently widely used NAND flash memory due to its complex structure and other reasons, and its security is in doubt. The recycling industry of waste electronic equipment, mainly smart phones, is facing the problem of lack of information security clearance. In addition to the hidden dangers of information security, this situation also leads to the low recovery rate of waste electronic equipment, which leads to potential waste of resources and environmental pollution. In view of the above problems, this article reviews the information erasure for NAND flash based on the overwrite technology to support the in-depth research of the information erasure technology. At first, it introduces the definition and classification of information erasure. Then, the characteristics of NAND flash memory is analyzed. Thirdly, it summarizes the information erasure technology based on overwriting. And the research difficulties and application difficulties of information erasure technology for NAND flash memory is discussed and analyzed. Finally, conclusions and prospect the future research direction of overwrite-based information erasure technology for NAND flash are given out.
EDITA EL PUEC. PRESENTAN UN LIBRO ACERCA DE LOS PROBLEMAS DE LA ZONA METROPOLITANA DE LA CAPITAL (1997)

EN EL LIBRO EMERGENTES DE LA ZONA METROPOLITANA DE LA CIUDAD DE EDITADO POR EL PROGRAMA UNIVERSITARIO DE ESTUDIOS SOBRE LA CIUDAD (PUEC), DIVERSOS ESPECIALISTAS ABORDAN LOS PROBLEMAS SOCIALES, POLITICOS Y ECONOMICOS MAS IMPORTANTES QUE AQUEJAN A LA URBE MAS POBLADA DEL MUNDO. FUE COORDINADO POR EL FISICO SERGIO REYES LUJAN, COORDINADOR DE VINCULACION Y DIRECTOR DEL PUEC, Y POR EL LICENCIADO MOISES CASTILLO GARCIA, SECRETARIO ACADEMICO DE ESTE PROGRAMA UNIVERSITARIO. EN LA PRESENTACION DE LA OBRA, EFECTUADA EL 22 DE SEPTIEMBRE EN LA CASA UNIVERSITARIA DEL LIBRO, LOS DOCTORES MANUEL PERLO COHEN, DEL INSTITUTO DE INVESTIGACIONES SOCIALES (IIS); FRANCISCO COVARRUBIAS GAYTAN, PROFESOR DE LA FACULTAD DE ARQUITECTURA (FA), Y ALFONSO IRACHETA CENECORTA, DIRECTOR GENERAL DE PLANEACION DEL GOBIERNO DEL ESTADO DE MEXICO, SENALARON LA NECESIDAD DE DAR A LOS ESTUDIOS DE LA CIUDAD DE MEXICO UN ENFOQUE MULTI E INTERDISCIPLINARIO.