gebhart/patrepeval huggingface dataset:
Auditory analysis of xeroderma pigmentosum 1971–2012: hearing function, sun sensitivity and DNA repair predict neurological degeneration (2013)

To assess the role of DNA repair in maintenance of hearing function and neurological integrity, we examined hearing status, neurological function, DNA repair complementation group and history of acute burning on minimal sun exposure in all patients with xeroderma pigmentosum, who had at least one complete audiogram, examined at the National Institutes of Health from 1971 to 2012. Seventy-nine patients, aged 1-61 years, were diagnosed with xeroderma pigmentosum (n = 77) or xeroderma pigmentosum/Cockayne syndrome (n = 2). A total of 178 audiograms were included. Clinically significant hearing loss (>20 dB) was present in 23 (29%) of 79 patients. Of the 17 patients with xeroderma pigmentosum-type neurological degeneration, 13 (76%) developed hearing loss, and all 17 were in complementation groups xeroderma pigmentosum type A or type D and reported acute burning on minimal sun exposure. Acute burning on minimal sun exposure without xeroderma pigmentosum-type neurological degeneration was present in 18% of the patients (10/55). Temporal bone histology in a patient with severe xeroderma pigmentosum-type neurological degeneration revealed marked atrophy of the cochlear sensory epithelium and neurons. The 19-year mean age of detection of clinically significant hearing loss in the patients with xeroderma pigmentosum with xeroderma pigmentosum-type neurological degeneration was 54 years younger than that predicted by international norms. The four frequency (0.5/1/2/4 kHz) pure-tone average correlated with degree of neurodegeneration (P < 0.001). In patients with xeroderma pigmentosum, aged 4-30 years, a four-frequency pure-tone average ≥10 dB hearing loss was associated with a 39-fold increased risk (P = 0.002) of having xeroderma pigmentosum-type neurological degeneration. Severity of hearing loss parallels neurological decline in patients with xeroderma pigmentosum-type neurological degeneration. Audiometric findings, complementation group, acute burning on minimal sun exposure and age were important predictors of xeroderma pigmentosum-type neurological degeneration. These results provide evidence that DNA repair is critical in maintaining neurological integrity of the auditory system.
Mechanism of Synergistic Antitumor Effect of Sorafenib and Interferon-α on Treatment of Renal Cell Carcinoma (2010)

Our results show the synergistic activity of interferon-α and sorafenib. These findings provided the rationale for combination therapy with interferon-α and sorafenib in patients with advanced renal cell carcinoma.
DEĞİŞİK ORİJİNLİ SEÇİLMİŞ İKİ BEYAZ LEGHORN VE İKİ NEW HAMPSHİRE SÜRÜSÜNDE YUMURTA AĞIRLIĞI VE YUMURTA KABUK AĞIRLIĞINA AİT TEKRARLAMA DERECELERİ (1983)

Yumurta agirligi ve yumurta kabuk agirligina ait tekrarlama derecelerinin hesaplanmasinda 2 secilmis Leghorn ve New Hampshire surusundeki tavuklarin ferdi kayitlari kullanilmistir. Arastirma Veteriner Fakultesi'nin Deneme Ciftliginde yurutulmustur. Yumurta agirligina ait tekrarlama dereceleri Konya orijinli secilmis New Hampshire ve Leghorn ile Danimarka orijinli secilmis New Hampshire ve Leghorn surulerinde sirasiyla 0.24 ± 0.07, 0.18 ± 0.06, 0.25 ± 0.06 ve 0.25 ± 0.06 dir. Yumurta kabuk agirligina ait tekrarlama dereceleri de yukaridaki sira ile 0. 025 ± 0.06, -0.08, -0.06 ve -0.12 seklindedir.
Identification of promising <scp>DNA</scp> GyrB inhibitors for Tuberculosis using pharmacophore‐based virtual screening, molecular docking and molecular dynamics studies (2017)

In this study, we searched for potential DNA GyrB inhibitors using pharmacophore-based virtual screening followed by molecular docking and molecular dynamics simulation approaches. For this purpose, a set of 248 DNA GyrB inhibitors was collected from the literature and a well-validated pharmacophore model was generated. The best pharmacophore model explained that two each of hydrogen bond acceptors and hydrophobicity regions were critical for inhibition of DNA GyrB. Good statistical results of the pharmacophore model indicated that the model was robust in nature. Virtual screening of molecular databases revealed three molecules as potential antimycobacterial agents. The final screened promising compounds were evaluated in molecular docking and molecular dynamics simulation studies. In the molecular dynamics studies, RMSD and RMSF values undoubtedly explained that the screened compounds formed stable complexes with DNA GyrB. Therefore, it can be concluded that the compounds identified may have potential for the treatment of TB.
Endometrial cancer screening in patients with Lynch syndrome. (2011)

5108 Background: Patients with Lynch syndrome are at high risk for endometrial cancer. Gynecologic screening is recommended although no screening tool has been validated. The objective of this study was to assess the diagnostic value of clinical examination, ultrasound and hysteroscopy to screen for atypical hyperplasia and cancer in women at risk for hereditary nonpolyposis colorectal cancer. Endometrial biopsy was the reference standard. Methods: Of 113 women with mismatch repair gene mutations or Amsterdam II criteria who were prospectively followed at our institution, 111 had 207 paired clinical examination-biopsy evaluations, 161 paired ultrasound-biopsy evaluations and 173 hysteroscopy-biopsy evaluations and were included in the study. Any abnormal bleeding was considered as suspicious. Transvaginal or transabdominal ultrasonographic finding was considered normal if no polyps or intrauterine abnormalities were seen and if the maximum endometrial thickness was less than 4 mm in postmenopausal women not receiving hormonal replacement therapy or less than 6 mm in other women. Hysteroscopy findings were considered as normal or suggesting abnormal or possibly malignant lesions. Endometrial biopsy results were categorized as not interpretable, normal, or showing atypical hyperplasia or cancer. Sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio of clinical examination-ultrasound-hysteroscopy-biopsy were computed. Results: The 111 patients had a mean age of 40.6 years and a median follow-up duration of 11 months (range, 0-140 months). Cancer was diagnosed in 7 patients. There was no atypical hyperplasia. Clinical examination, ultrasonography and hysteroscopy had respectively 86%, 75% and 100% sensitivity and 99%, 55% and 100% negative predictive value, 6.59, 1.67 and 5.63 positive likelihood ratio, and 0.16, 0.45 and 0 negative likelihood ratio. No interval cancers occurred. Conclusions: Hysteroscopy had excellent diagnostic value in this study. Further studies are needed to confirm these results and to determine usefulness of screening.
Shaping and finishing of aspherical optical surfaces (1998)

57 2.5 Accuracy considerations 59 2.5.1 Compensation 60 2.5.2Error propagation 62 2.5.3Relative speed along the Curve 79 2.5.4Summary 83 2.6 Conclusions 87 Contents viii 3. FAUST 89 3.1 Characteristics 89 3.1.1Functioning principle 89 3.1.2Production steps 90 3.2 Accuracy analysis 93 3.2.1 Compensation techniques 94 3.2.2Error propagation 98 3.3 Process simulation 99 3.4 Machine design 104 3.5 Conclusions 107 4. WAGNER 109 4.1 Characteristics 109 4.1.1Functioning principle 109 4.1.2Production steps 111 4.2 Accuracy analysis 112 4.3 Machine designs 113 4.3.1 Machining head 113 4.3.2Generation of arbitrary shapes 115 4.3.3Generation of conic surfaces 118 4.3.4Process simulation 125 4.4 Example: generation of an off-axis hyperboloidal surface 128 4.5 Conclusions 132 5. Experiments on novel finishing techniques 133 5.1 Fluid Jet Polishing (FJP) 133 5.1.1Characteristics 133 5.1.2Experiments 135 5.1.3Feed controlled FJP 142 5.1.4Conclusions 146 5.2 Loose abrasive Line-contact Ductile Grinding (LLDG) 148 5.2.1 Characteristics 148 5.2.2 Experiment 148 5.2.3 Conclusions 149 Contents ix 6.General conclusions and suggestions 151 6.1 Conclusions 151 6.2 Suggestions 155 6.2.1 NRS 155 6.2.2 FAUST 155 6.2.3 WAGNER 156 6.2.4 FJP 158 Appendix A Conic surfaces 161 A.1 Derivation of the function f c (r) 161 A.2 Function characteristics 164 Appendix B Intersection curve shape (Path) for on-and off-axis conic surfaces 1 7 1 B.1 Introduction 171 B.2 Paraboloidal surfaces 173 B.3 Ellipsoidal surfaces 174 B.4 Spherical surfaces 175 B.5 Hyperboloidal surfaces 176 Appendix C Applying an elliptical Path with a negative off-axis parameter 1 7 9 C.1 Applying an elliptical Path 179 C.1.1The projection of the Path onto the t, y r plane is an oblate ellipse (u >v cosa) 181 C.1.2The projection of the Path onto the t, y r plane is a circle (u =v cosa) 182 C.1.3The projection of the Path onto the t, y r plane is a prolate ellipse (u <v cosa) 182 C.2 Radial distance of a point located on an elliptical Path 187 C.3 The generation of off-axis parts of semi-ellipsoids 189
Segment Level Authentication: Combating internet source spoofing (2010)

This paper presents SLA (Segment Level Authentication), a transport segment level solution designed to prevent both of the intra-domain and inter-domain source spoofing. SLA is based on public key cryptography authentication. It enables intermediate network nodes the ability to validate the packet authenticity by verifying authentication information carried in packets. Although public key cryptography is computationally intensive and induces the traffic overhead, SLA leverages FPGA (Field Programmable Gate Array) based ECC (Elliptic Curve Cryptography) hardware cryptography accelerator to decrease the computation and traffic overhead. SLA provides incremental deployment and offers incentives for both of hosts and ASes. We find that the SLA is feasible for Gigabit links and can effectively mitigate source spoofing in both of intra-domain and inter-domain networks.
The roles and mechanisms of PAR4 and P2Y<sub>12</sub>/phosphatidylinositol 3‐kinase pathway in maintaining thrombin‐induced platelet aggregation (2010)

These results suggest that PAR4 acts in parallel with the P2Y(12)/PI3K pathway to stabilize platelet aggregates, and provide new insights into the mechanisms of thrombus stabilization and potential applications for antithrombotic therapy.
ChemInform Abstract: ESTIMATION OF THE FREE ENERGIES OF ADDITION OF NUCLEOPHILES TO CONJUGATED CARBONYL COMPOUNDS AND TO ACYL DERIVATIVES (1978)

Abstract Es wird die Addition von Nucleophilen wie z.B. Wasser, Methanol oder Hydrazin an Aldehyde, Amide und Acylderivate wie z.B. (I), (II) und (III) betrachtet.
Inductance effect in crosstalk prediction (2002)

Rapid progress in integrated circuit technology has led to an increase in switching speeds of digital circuits. This increase is the primary reason why inductance noise causes chips to fail. As a result, there is a growing interest in the inductance associated with on-chip signal lines. In this paper, we present the electromagnetic analysis we have followed in order to determine the accurate values of the R,L,C,G equivalent parameters from which a set of multiple coupled transmission lines could be modeled. We then determine the most critical parameters which make the inductance effect important and we propose a new analytical expression to accurately evaluate the crosstalk voltage.
γA/γ’ fibrinogen inhibits thrombin-induced platelet aggregation (2008)

The minor gammaA/gamma' fibrinogen isoform contains a high affinity binding site for thrombin exosite II that is lacking in the major gammaA/gammaA fibrinogen isoform. We therefore investigated the biological consequences of the gamma' chain binding to thrombin. Thrombin-induced platelet aggregation was inhibited by gammaA/gamma' fibrinogen. Carboxyl terminal peptide fragment gamma'410-427 from the gamma' chain was also inhibitory, with an IC(50) of approximately 200 microM in whole plasma. Deletion of the peptide from either the amino or carboxyl end significantly decreased inhibition. In contrast to thrombin-induced platelet aggregation, aggregation induced by epinephrine, ADP, arachidonic acid, or SFLLRN peptide showed little inhibition by the gamma' peptide. The inhibition of thrombin-induced platelet aggregation was not due to direct inhibition of the thrombin active site, since cleavage of a small peptidyl substrate was 91% of normal even in the presence of 1 mM gamma'410-427. The gamma'410-427 peptide blocked platelet adhesion to immobilized thrombin under both static and flow conditions, blocked soluble thrombin binding to platelet GPIbalpha, and inhibited PAR1 cleavage by thrombin. These results suggest that the gamma' chain of fibrinogen inhibits thrombin-induced platelet aggregation by binding to thrombin exosite II. Thrombin that is bound to the gamma' chain is thereby prevented from activating platelets, while retaining its amidolytic activity.
On the usage of standardised M2M platforms for Smart Energy management (2014)

The intention of the Machine-to-Machine (M2M) communication paradigm is to connect human and physical things related to different aspects in our daily life, in order to enable the development of Smart Cities. Recently, many initiatives emerged developing new solutions to achieve higher energy efficiency for buildings, better transportation management, and stronger Smart Grids. In this paper, we highlight our work in devolving a software reference implementation of the ETSI/oneM2M standards, which promote the research and development at academia and industry to rapidly realize proof-of-concept testbeds for Smart City, and demonstrate the interweaving with other platforms in the M2M communication and Smart Energy area.
Myoblast Transfer Therapy for Duchenne Muscular Dystrophy (1991)

A randomly selected extensor digitorum brevis (EDB) muscle in each of three Duchenne muscular dystrophy (DMD) boys aged 9 to 10 was injected with approximately 8 x 10(6) myoblasts. The contralateral EDBs were sham-injected with carrier solution. Donor myoblasts were derived from cell culture of muscle biopsies from the normal ward or normal brothers of the recipients. Cyclosporine (CsA) treatment began two days before myoblast injection and continued for three months. Three days prior to myoblast injection and three months after, the isometric twitch and maximum voluntary contraction of the left and the right EDBs were measured. Myoblast-injected EDBs showed increases in tensions whereas sham-injected EDBs showed reductions. Both immunocytochemical staining and immunoblot revealed dystrophin in the myoblast-injected EDBs. Dystrophic characteristics such as fiber splitting, central nucleation, phagocytic necrosis, variation in fiber shape and size, and infiltration of fat and connective tissues were less frequently observed in these muscles. Sham-injected EDBs exhibited significant structural and functional degeneration and no dystrophin. Throughout the study, there was no sign of erythema, swelling or tenderness at the injection sites. Serial laboratory evaluation including electrolytes, creatinine, and urea did not reveal any significant changes before or after myoblast transfer. We conclude that myoblast transfer therapy is a safe and efficacious procedure to improve the biochemistry, structure, and function of degenerative EDB muscles in DMD.
Stephen K. Hunter, MD, PhD (2011)

Stephen Hunter is a Professor and Division Director of Maternal-Fetal Medicine in the Department of Obstetrics and Gynecology at the University of Iowa. He’s an outstanding clinician, is the Associate Director of the Iowa Statewide Perinatal Care Program, and maintains a high-quality research program.
Degenerated four waves mixing in saturable dye-doped polymers: comparison of different xanthene dyes in poly(vinyl alcool) films (1995)

peer reviewed
Exercise issues related to the neuromuscular function and adaptation to microgravity (1989)

Explored here is the question of whether astronauts can perform extravehicular activities effectively, efficiently, and productively. The loss of muscle mass, movement control, central nervous system function, muscle atrophy and fatigue, all consequent to weightlessness exposure, are discussed. The author recommends more research in these areas.
Noise versus chaos in acousto-optic bistability (1984)

We present a study of the evolution to chaos for the acousto-optic bistable device. We numerically solve the difference-differential equation describing the system which shows excellent agreement with the experiment. We analyze the influence of noise---additive and multiplicative---on the bifurcation sequence and on the onset of chaos. It is shown experimentally that both types of noise create a gap in bifurcation sequence. In addition we present a comparison between theory and experiment of the time evolution of the signal.
[Hypertonic solutions in treatment of intracranial pressure]. (1993)

Administration of hypertonic solutions is the method of choice for acute treatment of intracranial hypertension. Recording of the intracranial pressure during treatment facilitates adjustment of the dosis to the actual ICP-response, avoiding thereby administration of an excessive osmotic load as a basis to prolong therapeutical efficacy. The mechanisms underlying reduction of the intracranial pressure by hypertonic solutions are still controversially discussed. Dehydration of normal probably also of edematous brain parenchyma and constriction of cerebral resistance vessels as an autoregulatory response causing reduction of the intracranial blood volume are the most likely options. Administration of hypertonic/hyperoncotic solutions has regained attention on account of its unmatched therapeutical efficacy to reestablish normal conditions in severe hemorrhagic shock. Administration of, e.g. 7.2% NaCl/10% Dextran 60 in an amount equivalent of only 10% of the shed blood volume is immediately normalizing cardiac output and improving the microcirculation in peripheral organs. These therapeutical properties are relevant in head injury, since inflicted patients quite often are suffering from peripheral trauma and consequently from hemorrhagic shock. No evidence has been obtained in a variety of experimental studies that hypertonic/hyperoncotic solutions have adverse effects on the brain in the presence of a cerebral lesion. To the contrary, the fluid mixture has been found to lower the increased intracranial pressure. Administration of hypertonic/hyperoncotic solutions appears therefore appropriate in acute cerebral insults from head injury and impending circulatory failure from shock in order to inhibit development of secondary brain damage.
Pharmacokinetics of a long-acting ceftiofur crystalline-free acid formulation in Asian elephants (Elephas maxim us) (2012)

Elephants tolerated CCFA at a dose of 6.6 mg/kg, SC, well. Dosing recommendations will depend on the mean inhibitory concentration of ceftiofur for each bacterial pathogen. Desfuroylceftiofur acetamide concentrations remained > 0.25 μg/mL for the entire 168-hour study period, which suggested CCFA would provide clinically relevant antimicrobial activity against certain pathogens for 7 to 10 days.
Relationship Between Symptom Severity and Hormone Changes in Women With Premenstrual Syndrome* (1989)

The relationship between symptoms and plasma hormone levels was investigated during 2 consecutive cycles in 18 women with the premenstrual tension syndrome (PMS). The women were asked to provide daily symptom ratings using a previously described and tested rating scale, and blood samples were taken daily during the luteal phase and most of the follicular phase for plasma estradiol, progesterone, FSH, and LH measurements. The symptom scores during the premenstrual phase were compared within each woman and between cycles with higher luteal phase and cycles with lower luteal phase plasma estradiol, progesterone, FSH, and LH concentrations. The results indicated that higher adverse premenstrual scores occurred in cycles with high luteal phase plasma estradiol and progesterone concentrations. In particular, a high luteal phase plasma estradiol concentration was related to higher premenstrual scores for adverse symptoms and lower scores for positive mood symptoms. The women experienced more severe PMS in cycles with high luteal phase plasma estradiol and progesterone levels. The results contradict the hypothesis that progesterone deficiency plays a part in the etiology of PMS.
Classification of Metaphyseal Change with Magnetic Resonance Imaging in Legg-Calvé-Perthes Disease (2000)

Seventy-eight patients (85 affected hips and 71 unaffected hips) with Legg-Calvé-Perthes disease were included in this study to evaluate the metaphyseal change in radiographs and magnetic resonance imaging (MRI) and to define the type of the metaphyseal cyst according to presence or absence of the epiphyseal involvement. The content of the metaphyseal cyst was evaluated by using T1,T2, proton, and gadolinium-enhanced T1-weighted MRI scans. Among 85 hips, there were no changes in 32 hips, marrow edema in 13 hips, false cyst with epiphyseal involvement in 28 hips, and true cyst without epiphyseal involvement in 12 hips. Granulation tissue was found in the false cysts and water-rich fibrotic tissue was found in the true cysts based on the MRI scans. The metaphyseal change in MRI scans was shown in 71% of groups 3 and 4 and in 35% of groups 1 and 2 according to the Catterall classification, and 52% of group A, 56% of group B, and 86% of group C according to the Herring classification. Of the 30 hips at the avascular stage, 33% showed metaphyseal cyst in MRI scans. Of the 53 hips at the fragmentation stage, 60% showed the metaphyseal cyst.
ChemInform Abstract: Reduction of Silicon‐Hydrogen Bond Strengths. (1987)

Abstract Bond dissociation energies (BDE) measured by a photoacoustic technique (nitrogen laser pulses, 337 nm, pulse width 10 ns, h·ü = 84.8 kcal/mol) on deoxygenated solutions containing tBu‐O‐O‐tBu (4‐16% v/v) and an appropriate silane in isooctane yields ΔHobsd/BDE(R3Si‐H) (in kcal/mol): Et 3 Si‐H = 76.3/90.1; Me 3 Si‐SiMe2‐H = 84.9/85.3; (Me 3 Si) 3 Si‐H = 95.9/79.0; in general BDE(R3Si‐H) = ΔHR/2 + 86.1 kcal/mol.
Three-Dimensional Electrophysiological Imaging of the Intact Canine Left Ventricle Using a Noncontact Multielectrode Cavitary Probe: Study of Sinus, Paced, and Spontaneous Premature Beats (1998)

Noncontact mapping provides realistic, three-dimensional electrophysiological images of the endocardium, on a beat-by-beat basis, that localize the sites of origin of premature beats and reconstruct their activation sequences.