gebhart/patrepeval huggingface dataset:
Serum 7α-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea (1996)

The positive predictive value of serum 7 alpha-3ox-C was 74%. The high negative predictive value (98%) of serum 7 alpha-3ox-C indicates the possible use of this test for excluding bile acid malabsorption in this population. All but two subjects who responded to treatment had raised serum 7 alpha-3ox-C concentrations. The possibility that the sensitivity of the test can be improved by repeat testing needs to be further investigated. There was a significant correlation between fractional catabolic rate (FCR) SeHCAT and serum 7 alpha-3ox-C (r = 0.63, P < 0.0001). Further data are required to validate the reference range in women over 70 years of age.
Low risk of viral infection after administration of vapor‐heated factor VIII concentrate (1992)

A multicenter prospective study was carried out to evaluate whether a vapor-heated factor VIII concentrate transmitted blood-borne viral infections over a surveillance period of 15 months. Thirty-five patients with hemophilia and von Willebrand disease who had never received any blood components were treated. Twenty-eight were analyzed and found not to have non-A, non-B hepatitis. Sera from 20 of these 28 patients were also tested for the antibody to the hepatitis C virus. None had sero-converted during the follow-up period. None of the patients analyzed developed markers of the hepatitis B virus (n = 17) or the human immunodeficiency virus (n = 31). This vapor-heated factor VIII concentrate carries a low risk of transmitting hepatitis and human immunodeficiency virus infection.
Positioning and Driving Control of Fork-type Automatic Guided Vehicle With Laser Navigation (2013)

We designed and implemented a fork-type automatic guided vehicle (AGV) with a laser guidance system. Most previous AGVs have used two types of guidance systems: magnetgyro and wire guidance. However, these guidance systems have high costs, are difficult to maintain with changes in the operating environment, and can drive only a pre-determined path with installed sensors. A laser guidance system was developed for addressing these issues, but limitations including slow response time and low accuracy remain. We present a laser guidance system and control system for AGVs with laser navigation. For analyzing the performance of the proposed system, we designed and built a fork-type AGV, and performed repetitions of our experiments under the same working conditions. The results show an average positioning error of 51.76 mm between the simulated driving path and the driving path of the actual fork-type AGV. Consequently, we verified that the proposed method is effective and suitable for use in actual AGVs.
Optimal Control of Complex Structures (2002)

Interest in the area of control of systems defined by partial differential Equations has increased strongly in recent years. A major reason has been the requirement of these systems for sensible conti
Histochemically demonstrable protein tyrosine phosphatase in human breast and colorectal cancer: large decrease in its activity in colorectal cancer suggests a tumor suppressor role in colorectal mucosal cells. (1996)

Many oncogene products and growth factor receptors are protein tyrosine kinases, and exert their cellular effects by the phosphorylation of tyrosyl residues of effector proteins. The balance and dynamic renewal of phosphotyrosine proteins are also regulated by protein tyrosine phosphatases (PTPs), whose inhibition under experimental conditions causes cellular proliferation and transformation, with a concomitant increase in phosphotyrosine protein content. Inverse effects are obtained by increasing PTP activity. On the basis of these effects, PTPs might also function as tumor suppressors in human tissues. This possibility was further investigated here by demonstrating PTP and phosphotyrosine protein content with histochemical techniques. In normal human breast tissue PTP activity was low and in the majority of breast cancers the activity was increased and exhibited great variation between different cases. When the relationship of phosphotyrosine protein content with PTP was evaluated, no inverse dependence was detected, suggesting that in human breast tissue and cancer PTP may not show tumor suppressor activity. In normal colorectal mucosae PTP activity was high, while in all colorectal cancers it was very low, constituting only 14% of the activity present in normal mucosal cells. The great drop in PTP activity together with reported alterations in a gene encoding a PTP and in a chromosome containing a PTP gene in colorectal cancer strongly suggest that PTP may function as a tumor suppressor in human colorectal mucosae. The decrease in PTP activity may be one factor stimulating or causing neoplastic proliferation in multistep colorectal carcinogenesis.
A study of hydrothermally grown ZnO nanorod-based metal-semiconductor-metal UV detectors on glass substrates (2017)

This study reports hydrothermally grown zinc oxide nanorod-based metal-semiconductor-metal ultraviolet detectors with palladium metal as the electrodes. The zinc oxide nanorods were deposited on glass substrates in two steps, seed layer deposition and growth of nanorods. The structural and optical properties of nanorods were examined using scanning electron microscopy and ultraviolet–vis spectroscopy, respectively. The scanning electron microscopy image showed that the growth of nanorods was uniform, and the ultraviolet–vis results indicate that the bandgap of zinc oxide nanorods was 3.23 eV. For metal-semiconductor-metal devices, interdigited metal electrodes with equal interelectrode spacing and a width of 0.3 mm were deposited above the zinc oxide nanorod thin films with a shadow mask using a thermal evaporation system. The current–voltage characteristics of the metal-semiconductor-metal detector were investigated and it showed a contrast ratio of approximately 2.10 and responsivity of approximately 0.199 A/W at 1.8 V. These results are expected to be beneficial to fabricating cheap and practical ultraviolet detection applications.
Third-Line Chemotherapy for Advanced Non-Small-Cell Lung Cancer — Is There Enough Evidence to Support Its Use? (2005)

Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C. *Correspondence to: Dr. Chih-Hsin Yang, Department of Oncology, National Taiwan University Hospital, 7, Chung San South Road, Taipei 100, Taiwan, R.O.C. E-mail: [email protected] Received: October 6, 2004 • Accepted: December 9, 2004
Thomas Barton, D.D. (1964)

Thomas Barton, D.D. Get access C. H. & Thompson Cooper C. H. & Thompson Cooper Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s3-VI, Issue 154, 10 December 1864, Pages 470–471, https://doi.org/10.1093/nq/s3-VI.154.470-c Published: 10 December 1964
Effect of indomethacin on allergen-induced asthmatic responses (1989)

Previous studies have suggested that inhibition of the cyclooxygenase pathway of arachidonic acid metabolism may suppress the late asthmatic responses to inhaled allergen. Both human and animal studies have suggested that prostanoids may also be involved in increases in airway responsiveness after ozone and allergen. We studied seven atopic subjects, who had a dual asthmatic response to inhaled allergen, during a control period and then after pretreatment with indomethacin (50 mg) or placebo twice daily for 2 days, administered in a randomized, double-blind manner. Indomethacin had no significant effect on the base-line airway responsiveness to histamine (P = 0.22) or the allergen-induced early or late asthmatic response (P = 0.49). However, indomethacin inhibited the increase in airway responsiveness (express as histamine PC20) after allergen inhalation. The log difference in preallergen to postallergen histamine PC20 was 0.49 +/- 0.08 (SE) during the control period, 0.46 +/- 0.08 (SE) after placebo (P = 0.81), and 0.22 +/- 0.10 (SE) after indomethacin (P = 0.02). Although indomethacin is useful for examining the role of cyclooxygenase products in asthmatic responses, it should not be considered in the treatment of asthma. We conclude that cyclooxygenase products are not significant mediators of allergen-induced early or late asthmatic responses but are involved in the pathogenesis of airway hyperresponsiveness after allergen inhalation.
Evolution of Cognitive Function via Redeployment of Brain Areas (2007)

The creative reuse of existing neural components may have played a significant role in the evolutionary development of cognition. There are obvious evolutionary advantages to such redeployment, and the data presented here confirm three important empirical predictions of this account of the development of cognition: 1) A typical brain area will be used by many cognitive functions in diverse task categories, (2) evolutionarily older brain areas will be deployed in more cognitive functions, and (3) more recent cognitive functions will use more, and more widely scattered, brain areas. These findings have implications not just for our understanding of the evolutionary origins of cognitive function but also for the practice of both clinical and experimental neuroscience.
Current Minimizing Torque Control of the IPMSM Using Ferrari’s Method (2013)

For the torque control of an interior permanent magnet synchronous motor (IPMSM), it is necessary to determine a current command set that minimizes the magnitude of the current vector. This is known as the maximum torque per ampere. In the field-weakening region, current minimizing solutions are found at the intersection with the voltage limits. However, the optimal problem yields fourth-order polynomials (quartic equations), and no attempt has been made to solve these quartic equations online for torque control. Instead, premade lookup tables are widely used. These lookup tables tend to be huge because it is necessary to create separate tables on the basis of the dc-link voltage and motor temperature. In this study, we utilize Ferrari’s method, which gives the solution to a quartic equation, for the torque control. Further, a recursive method is also considered to incorporate the inductance change from the core saturation. A simulation and some experiments were performed using an electric vehicle motor, which demonstrated the validity of the proposed method.
Regulation of Aspartyl-(Asparaginyl)-β-Hydroxylase Protein Expression and Function by Phosphorylation in Hepatocellular Carcinoma Cells. (2015)

Insulin/IGF-1 stimulation of AAH and Notch are enhanced by inhibiting kinases that could phosphorylate AAH protein. Targeted manipulation of AAH's phosphorylation state may have therapeutic value for reducing AAH-Notch activation and attendant infiltrative growth of hepatocellular carcinomas.
Privacy protection from sampling and perturbation in survey microdata (2012)

Statistical agencies release microdata from social surveys as public-use files after applying statistical disclosure limitation (SDL) techniques. Disclosure risk is typically assessed in terms of identification risk, where it is supposed that small counts on cross-classified identifying key variables, i.e. a key, could be used to make an identification and confidential information may be learnt. In this paper we explore the application of definitions of privacy from the computer science literature to the same problem, with a focus on sampling and a form of perturbation which can be represented as misclassification. We consider two privacy definitions: differential privacy and probabilistic differential privacy. Chaudhuri and Mishra (2006) have shown that sampling does not guarantee differential privacy, but that, under certain conditions, it may ensure probabilistic differential privacy. We discuss these definitions and conditions in the context of survey microdata. We then extend this discussion to the case of perturbation. We show that differential privacy can be ensured if and only if the perturbation employs a misclassification matrix with no zero entries. We also show that probabilistic differential privacy is a viable alternative to differential privacy when there are zeros in the misclassification matrix. We discuss some common examples of SDL methods where in some cases zeros may be prevalent in the misclassification matrix.
Current Constructs and Targets in Clinical Development for Antibody- Based Cancer Therapy (2009)

Almost ever since their invention, monoclonal antibodies have held the promise of cancer-specific drug targeting--Paul Ehrlich's "magic bullet"--but only during the past decade have a modest number of anti-cancer antibodies received approval for clinical use. These, however, have proven largely successful, with very different kinds of conventional or recombinant, murine, humanized, recombinant fully human and fusion constructs, and mechanisms of action as diverse as complement or antibody dependent cytotoxicity, anti-angiogenesis, and growth factor inhibition. In these latter two mechanisms of action, antibodies compete with novel small-molecule drugs. This review tries to elucidate current trends in those antibody-based therapeutics that are currently in clinical development. With more than 400 such molecules registered for clinical trials, it is far from a chance to be complete. Still, from those antibodies selected for a closer view, two large trends can be distilled: The movement towards increasingly molecularly defined recombinant constructs, and away from classical antibody effector functions in immune activation towards additional mechanisms of action--either by stimulation or (more often) inhibition of a molecular target function, or by additional functional moieties attached to the antibody scaffold. While these trends probably mark the future of antibody development for cancer therapy and clinical applications in general, a considerable number of more conventional--hybridoma generated or recombinantly chimerized or humanized--Fc receptor-activating antibodies, originally generated a decade or longer ago, continue to make their way through clinical trials, some with remarkable success.
Abstract: Reservoir Recovery Factor 40–50% ?! Time Lapse Seismic (4D) will pay back 10–20 times its cost even at $30 a barrel (2007)

Abstract In the early days of 3D seismic (in the late 70's through to the early 90's) it was always difficult to justify using this new -- the industry tends to be conservative, and commercial case history successes attributed to 3D seismic technology were slow in being published. By the early 2000's, however, if proposing a 2D seismic survey, then during the approvals process one would expect to have to justify not acquiring 3D seismic data. 4D seismic has had a slightly faster take-up. We should ask ourselves why approximately 80% of all seismic work in the North Sea is shot and processed for time-lapse (4D) purposes — in fact for the major oil companies in the North Sea, 4D represents over 90% of their work program in that area. We should also ask ourselves why this situation came to pass in the late 90's, even when the oil price was below $25 per barrel. The answers should be no surprise — most of the reservoirs in the North Sea were in decline by the late 90's, and those people who were charged with maximizing the flow rates and/or the reservoir recovery factors began to use technologies such as 4D which was beginning to make a significant impact. At about the same time, it gradually became apparent that 4D could probably make a greater contribution if applied early in the of a -- even extended well-tests produced useful 4D results over periods of just a few months, and these could show up some of the important architecture of the reservoir. Commercial case histories for 4D appeared relatively quickly compared to 3D and assisted the take-up of the method. Several of these will be presented in detail, together with a review of the current state of the science including life of field systems which are producing several pictures of the reservoir in a 12 month period, almost allowing a movie of the changes in the reservoir. The technology is evolving but its directions are clear and will be described in this paper. Presented at: 2007 South East Asia Petroleum Exploration Society (SEAPEX) Conference, Singapore, 2007
Effects of high voltage pulsed current stimulation with a visible contraction intensity on expression of TGF-β1 and synthesis of type I collagen in wound-induced white rats (2015)

[Purpose] This study aimed to examine the expression of transforming growth factor β1 (TGF-β1) and type I collagen by applying high voltage pulsed current stimulation (HVPCS) with a visible contraction intensity to white rats with induced wounds. [Subjects] Thirty-six white rats were used for this study. HVPCS with a non-visible contraction intensity was applied to experimental group I, and HVPCS with a visible contraction intensity was applied to experimental group II. Placebo stimulation was applied to the control group. [Methods] After wounds were triggered, the intervention appropriate for each group was applied. Changes in the size of their wounds and expression of TGF- β1 and type I collagen were measured on the third, fifth, and seventh days. [Results] Comparison of the sizes of the wounds among the groups showed that the most significant decreases were found in experimental group II on the fifth and seventh days. TGF-β1 expression comparison revealed that experimental group II had the most expression on the fifth day. [Conclusion] HVPCS with a visible contraction intensity was effective in promoting wound healing by increasing expression of TGF-β1 and synthesis of type I collagen.
Ueber Amidoderivate des Chinolins III (1893)

n a u f D i p h e n y l c h l o r k y a n i d i n .Zur Darstellung von Diphenylanilidokyanidin (Diphenylphenylamidokyanidin) (Cg H J ) ~ .C3 NS .NH .CsH5 schmilzt man Diphenylchlorkyanidin mit der halben Gewichtsmenge Anilin zusammen.Nach der Behandlung des Reactionsproductes rnit
Statistical evaluation of optimum islanding preventing method for utility interactive small scale dispersed PV systems (2002)

The optimum islanding preventing method for the small scale dispersed PV system were evaluated, based on a simulation analysis concerning the occurrence probability of islanding phenomenon in actual operation. As a result, it is sufficient to adopt only one developed measure when the PV penetration ratio to distribution line capacity is less than 20% to 30%. It is necessary to adopt a combination method consisting of 2 or more developed measures when the penetration ratio is more than 40%. The harmonic monitoring method is effective in the case of using it in a combination method.
Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial (2012)

Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.
Alkylation specificity for a series of distamycin analogues that tether chlorambucil. (1997)

The sequence specificity of alkylation for a series of pyrrole- and imidazole-containing analogues of distamycin that tether the nitrogen mustard chlorambucil (CHL) was determined using modified sequencing techniques. Examination of the sequence specificity of alkylation for the imidazole-CHL conjugates using a Taq polymerase stop assay revealed that although the doses required to produce similar amounts of damage were at least 10-fold lower, the sequence specificity of alkylation was essentially identical to that seen for CHL. The guanine-N7 alkylation pattern, which consisted of guanines within runs of guanines, was confirmed using a piperidine cleavage assay. The pyrrole-CHL conjugates also produced a similar pattern of alkylation to that seen for CHL, but one exception was a unique site strongly alkylated only by the di- and tripyrrole-CHL conjugates. The unique lesions, at AG for the dipyrrole-CHL conjugate and G for the tripyrrole-CHL conjugate in the sequence 5'-GAAGAT, were confirmed as minor groove adenine- and guanine-N3 lesions using a thermal cleavage assay.
Batch and fed-batch cultures of E. coli TB1 at different oxygen transfer rates (1998)

Batch cultures of E. coli TB1/pUC13 were carried out at different oxygen transfer rates (OTR) enhanced by the increase of stirring rate and by the increase of air total pressure of the bioreactor. These two variables showed to have little effect on cell growth but a negative effect on cytochrome b5 (recombinant protein) production. However, this effect was more significant of high stirring rates than for values of pressure up to 0.4 MPa. The effects of stirring and pressure were also investigated for fed-batch mode operation. In this type of cell cultivation high cell densities are reached, thus a high capacity of oxygen supply of the system is required. To compare the two ways of improving OTR, cell behaviour was followed in two bioreactors at different operational conditions giving the same maximum OTR value. The first one operated at a high stirring rate (500 rpm) and at atmospheric pressure (0.1 MPa) and the other one at high air pressure (0.48 MPa) and low stirring rate. The increased pressure seemed to be a better way of ensuring an adequate oxygen supply to a culture of E. coli TB1 cells than an increased stirring rate. For the high pressure experiment a higher cellular density was reached, as well as a higher cyt.b5 expression which led to a 4-fold increase in final productivity. These experiments showed that bioreactor pressurization can be successfully used as a means of enhancing oxygen mass transfer to shear sensitive cell cultures.
New approach for the low-speed operation of PMSM drives without rotational position sensors (1996)

A new approach to the position sensor elimination of permanent magnet synchronous machine (PMSM) drives for low-speed operation is presented in this paper. Using the position sensing characteristics of the PMSM itself, the actual rotor position, as well as the machine speed, can be obtained even in the transient state. Since the essential back-EMF information is obtained from direct measurement during a special test cycle called MCDI, the operating speed range of the sensorless drives can be extended to 10 RPM. Moreover, the chronic starting problem of PMSM drives can be simply settled by the proposed algorithm. In order to verify the feasibility of the proposed scheme, experimental results in the low-speed range of about 10/spl sim/100 RPM are also presented.