gebhart/patrepeval huggingface dataset:
DIRECT AND SENSITIZED PHOTOLYSIS OF ETHYL PYRUVATE (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDIRECT AND SENSITIZED PHOTOLYSIS OF ETHYL PYRUVATEGeorge S. Hammond, Peter A. Leermakers, and Nicholas J. TurroCite this: J. Am. Chem. Soc. 1961, 83, 10, 2395–2396Publication Date (Print):May 1, 1961Publication History Published online1 May 2002Published inissue 1 May 1961https://pubs.acs.org/doi/10.1021/ja01471a044https://doi.org/10.1021/ja01471a044research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Karyopherin α 3 and Karyopherin α 4 Proteins Mediate the Nuclear Import of Methyl-CpG Binding Protein 2 (2015)

Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein with important roles in regulating chromatin structure and gene expression, and mutations in MECP2 cause Rett syndrome (RTT). Within the MeCP2 protein sequence, the nuclear localization signal (NLS) is reported to reside between amino acids 255-271, and certain RTT-causing mutations overlap with the MeCP2 NLS, suggesting that they may alter nuclear localization. One such mutation, R270X, is predicted to interfere with the localization of MeCP2, but recent in vivo studies have demonstrated that this mutant remains entirely nuclear. To clarify the mechanism of MeCP2 nuclear import, we isolated proteins that interact with the NLS and identified karyopherin α 3 (KPNA3 or Kap-α3) and karyopherin α 4 (KPNA4 or Kap-α4) as key binding partners of MeCP2. MeCP2-R270X did not interact with KPNA4, consistent with a requirement for an intact NLS in this interaction. However, this mutant retains binding to KPNA3, accounting for the normal localization of MeCP2-R270X to the nucleus. These data provide a mechanism for MeCP2 nuclear import and have implications for the design of therapeutics aimed at modulating the function of MeCP2 in RTT patients.
TRIAC (3,5,3′‐triiodothyroacetic acid) has parallel effects at the pituitary and peripheral tissue levels in thyroid cancer patients treated with <scp>l</scp>‐thyroxine (1991)

Even at low dose and when combined with T4, TRIAC has parallel effects on the pituitary and peripheral tissues. There is no justification for the use of TRIAC as suppressive treatment in thyroid cancer patients.
S1-17 ENDOSCOPIC ENDONASAL APPROACH FOR THE RESECTION OF NASAL DERMOID CYSTS WITH INTRACRANIAL EXTENSION (2019)

Introduction: Nasal dermoid cysts with intracranial extension are generally treated via an open approach with bicoronal exposure and craniotomy, providing visualization of the intracranial extension. Here we present an alternative multidisciplinary technique to nasal dermoid cysts via a completely endoscopic endonasal approach with open rhinoplasty exposure. Methods: Patients who were diagnosed with nasal dermoid cysts with MRI findings suspicious for intracranial extension underwent resection via an endoscopic endonasal approach. The multidisciplinary operative team is comprised of a plastic surgeon, neurosurgeon, and otolaryngologist. Navigational head CT is performed at the time of surgery. Following the extracranial dissection of the nasal dermoid, the dermoid tract is traced through the nasal bones to the upper lateral cartilages. The endoscope is then used to resect the intracranial portion of the nasal dermoid and repair the dura if needed. The upper lateral cartilages may be taken down if additional exposure is needed for the endoscope and are resuspended following resection of the dermoid. Results: Five patients (mean age 2.0 years, range 16 months to 3.4 years) underwent endoscopic endonasal approach for excision of a nasal dermoid cyst. Preoperative MRI showed intracranial extension in two patients, and tracts extending into the foramen cecum, but no definitive intracranial extension in the other three patients. Frozen sections were sent to pathology in two cases to rule out remaining dermoid tissue. Average operative time was 6 hours and 10 minutes. Average blood loss was 26cc (range 15 to 40cc). One patient received a blood transfusion. No patient required conversion from an endoscopic approach to an open approach. Postoperative MRIs were obtained at 3 months in three patients and showed no recurrence; postoperative MRIs for the rest of the patients are pending. Follow-up MRIs are planned at 12 months. Conclusion: This is the largest series to date reporting the use of an endoscopic endonasal approach for nasal dermoid cysts with intracranial extension. Long operative time, which will likely decrease as experience increases, is a tradeoff for decreased morbidity and low blood loss compared to the traditional open procedure. Additional follow-up time is needed to determine if there is any difference in recurrence rate between the approaches.
Effect of Hypothermia on Experimental Pancreatitis (1961)

<h3>Introduction</h3> Because the exact etiology and pathogenesis of pancreatitis are unknown, definitive treatment is lacking, and the results of treatment are not entirely satisfactory. With the measures currently applied, the mortality rate from this disease is as high as 35%. For the reasons given below, hypothermia seemed to have a logical place in the treatment of this disease, and we endeavored to evaluate its use in the experimental form. Physical-chemical laws governing the rate of chemical reactions state that the rate of the reaction is proportional to the temperature.<sup>1</sup>For a 10-degree rise in temperature, enzymatic reaction rates will increase by a factor of 1.1 to 5.3, usually between 2 and 3. If the temperature is increased by 10 degrees centigrade the reaction rate should double or triple, while if the temperature is decreased by 10 degrees centigrade the rate should be approximately one-half of what it was. The
A 0.41mW Band-Tunable 6<sup>th</sup>-Order IF Filter with 40 ns Settling Time in 45 nm CMOS RFSOI (2019)

This work presents the design and implementation of a fully-differential 6 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> -order intermediate frequency (IF) bandpass filter (BPF) in 45 nm CMOS RFSOI. Its application targets are wake-up receivers (WuRX) that employ aggressive duty cycling. The fabricated filter with all bias circuits consumes a current of only 0.41mA from a 1V supply. Its center frequency is adaptive between 70 and 120 MHz, and the 3 dB-bandwidth is 20MHz. The BPF can settle within 40 ns. It occupies an area of 0.03mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . To the authors’ best knowledge, this circuit provides the lowest DC-power, the lowest DC-power per pole, the shortest settling time and the fewest area for IF BPFs reported to date.
Accelerating Drug Development in Pediatric Oncology With the Clinical Pharmacology Storehouse (2018)

Pediatric drug development is a challenging process due to the rarity of the population, the need to meet regulatory requirements across the globe, the associated uncertainty in extrapolating data from adults, the paucity of validated biomarkers, and the lack of systematic testing of drugs in pediatric patients. In oncology, pediatric drug development has additional challenges that have historically delayed availability of safe and effective medicines for children. In particular, the traditional approach to pediatric oncology drug development involves conducting phase 1 studies in children once the drug has been characterized and in some cases approved for use in adults. The objective of this article is to describe clinical pharmacology factors that influence pediatric oncology trial design and execution and to highlight efficient approaches for designing and expediting oncology drug development in children. The topics highlighted in this article include (1) study design considerations, (2) updated dosing approaches, (3) ways to overcome the significant biopharmaceutical challenges unique to the oncology pediatric population, and (4) use of data analysis strategies for extrapolating data from adults, with case studies. Finally, suggestions for ways to use clinical pharmacology approaches to accelerate pediatric oncology drug development are provided.
Workshop on the evaluation of multimedia retrieval (2005)

The evaluation of multimedia retrieval is a subject that has gained momentum in the last couple of years. CWI, the National Research Institute for Mathematics and Computer Science in the Netherlands, organised a workshop organised on the subject on 24 November 2004. The main aim of the workshop was to bring together researchers and practitioners in the field of multimedia retrieval to discuss the area of multimedia in general and methodology for evaluation within this area in particular. The workshop, organised by Franciska de Jong (Utwente/TNO, NL), Arjen de Vries (CWI, NL) and Thijs Westerveld (CWI, NL) was an informal half-day meeting without papers or proceedings. Because the workshop was co-located with Thijs Westerveld's PhD defence, we were able to invite Alex Hauptmann (CMU, PA, USA) to give a talk. In total six speakers were invited to present their work related to the evaluation of multimedia retrieval. The workshop started with a talk presenting multimedia retrieval in practise. Then, three talks discussed experiments in the laboratory context of the TRECVID video retrieval benchmark. The afternoon ended with a presentation of a study of interactive experiments and a talk discussing metrics for measuring multimedia retrieval effectiveness.
Late nodal metastasis of T2 oral cancer can be reduced by a combination of preoperative ultrasonographic examination and frozen section biopsy during supraomohyoid neck dissection (2011)

The occult metastasis rate was 18% when occult metastases were limited to those detected by SOHND and 22% when late nodal recurrences were also included.
Adenoviral-Mediated Modulation of<i>Sim1</i>Expression in the Paraventricular Nucleus Affects Food Intake (2006)

Haploinsufficency of Sim1, which codes for a basic helix-loop-helix-PAS (PER-ARNT-SIM) transcription factor, causes hyperphagia in mice and humans, without decrease in energy expenditure. Sim1 is expressed in several areas of the brain, including the developing and postnatal paraventricular nucleus (PVN), a region of the hypothalamus that controls food intake. We have previously found that the number of PVN cells is decreased in Sim1+/- mice, suggesting that their hyperphagia is caused by a developmental mechanism. However, the possibility that Sim1 functions in the postnatal PVN to control food intake cannot be ruled out. To explore this hypothesis, we used adenoviral vectors to modulate Sim1 expression in the postnatal PVN of wild-type mice. Unilateral stereotaxic injection into the PVN of an adenoviral vector producing a short hairpin RNA directed against Sim1 resulted in a significant increase in food intake, which peaked to 22% 6 d after the procedure, compared with the injection of a control virus. In contrast, injection of an adenovirus that expresses Sim1 induced a decrease in food intake that was maximal on the seventh day after the procedure, reaching 20%. The impact of bilateral injections of these vectors into the PVN was not greater than that of unilateral injections. Together, these results strongly suggest that Sim1 functions along a physiological pathway to control food intake.
ChemInform Abstract: A SHORT SYNTHESIS OF THE 4‐DEMETHOXY‐11‐DEOXYANTHRACYCLINE SKELETON. REGIOSPECIFIC ENOLATE C‐CARBOXYLATION WITH CARBON OXYSULFIDE (1983)

Abstract Aus 2‐Chlormethyl‐1 ,4‐dimethoxy‐naphthalin (I) erhält man nach Grignardreaktion, Umsetzung mit Trimethylchlorsilan und Metallierung das Derivat (II), aus dem mit Cyclohexenon (III) die Produkte (IV) oder (Va) bzw. mit Chlorkohlensäureester das Enolcarbonat (Vb) erhalten werden.
Imagerie médicale et tumeurs : diagnostic,orientation thérapeutique et suivi de l’efficacité des traitements. Conférence (2017)

CERVOXY
ChemInform Abstract: HOCHTEMPERATUR‐UMSETZUNG VON MONO‐ UND DIHALOGEN‐CARBENEN MIT CYCLOOLEFINEN (1974)

Abstract Beim Durchleiten von Methylenchloiid, Stickstoff und Cyclohexen (I) bei 600°C durch ein mit Quarzstücken gefülltes Quarzrohr (Kontaktzeit 1 ‐ 3 Sek.) entsteht 1,3‐Cycloheptadien (III) (Ausbeute 0,4% bezogen auf eingesetztes Cyclohexen).
Accelerating pattern matching for DPI (2007)

Pattern matching in network applications is characterized by intensive computation. In conventional hardware accelerating methods, performance versus cost is a trade-off. In this paper, we proposed a new Hash-CAM hybrid architecture using state-of-the-art FPGA technology that is customized for a given pattern matching problem for DPI.
Costimulation through ICAM-1 induces differentiation of naive human CD4+ T cells from aging individuals (85.27) (2007)

Abstract With age, the immune response is less effective at protection and less responsive to vaccines. The events leading to immunosenescence have not been fully described. We have been investigating the hypothesis that the nature of the T cell costimulatory signal governs in part the phenotype of the post thymic developing naïve T cell as it responds to cognate antigen. The costimulatory molecules, CD28 and LFA-1 are the best characterized; however we have demonstrated that ICAM-1, resident on a T cell, can receive signals that drive naïve human CD4+ T cells taken from young individuals to effector and memory phenotypes that differ from those induced by CD28 or LFA-1. For the present study, we are investigating the participation of these three costimulatory signals in activation and differentiation of human naive CD4+ T cells from aging individuals. We will describe differential effects on development in response to costimulation of naïve T cells taken from older as compared with young human subjects.
Regularization of an iterative algorithm for the extrapolation of bandlimited signals (1983)

info:eu-repo/semantics/published
Characterization of autoreactive helper T cells in a murine model of autoimmune haemolytic disease. (1993)

Repeated immunization of mice with rat red blood cells (RRBC) results in the production of both erythrocyte autoantibodies and anti-RRBC antibodies. The manner in which erythrocyte self-tolerance is broken has been little studied. It has been assumed that help for autoreactive B cells is provided by Th cells specific for the foreign RRBC. We show here that autoreactive Th cells can be recovered from RRBC-immunized mice. The Th cells proliferate in vitro whether stimulated by self or rat erythrocytes. Analysis of the specificity of the proliferating cells revealed extensive cross-reactivity for the two types of erythrocytes. It is therefore surprising that, in initial cultures, a slower response is evident when mouse erythrocytes are used as the antigen. From cytotoxic depletion of T-cell subsets, the phenotype of the proliferating cells was identified as Thy-1.2+, Lyt-1.1+, Lyt-2.1-, L3T4+. During in vitro stimulation of the T cells, growth factors characteristic of Th cells are secreted. Finally, we demonstrate that the responding T cells are able to help primary in vitro antibody responses to self and rat erythrocytes. We conclude that autoreactive Th cells are likely to be involved in the experimental induction of autoimmune haemolytic disease in mice.
Using task context to improve programmer productivity (2006)

When working on a large software system, a programmer typically spends an inordinate amount of time sifting through thousands of artifacts to find just the subset of information needed to complete an assigned task. All too often, before completing the task the programmer must switch to working on a different task. These task switches waste time as the programmer must repeatedly find and identify the information relevant to the task-at-hand. In this paper, we present a mechanism that captures, models, and persists the elements and relations relevant to a task. We show how our task context model reduces information overload and focuses a programmer's work by filtering and ranking the information presented by the development environment. A task context is created by monitoring a programmer's activity and extracting the structural relationships of program artifacts. Operations on task contexts integrate with development environment features, such as structure display, search, and change management. We have validated our approach with a longitudinal field study of Mylar, our implementation of task context for the Eclipse development environment. We report a statistically significant improvement in the productivity of 16 industry programmers who voluntarily used Mylar for their daily work.
Age-Dependent<i>Neisseria meningitidis</i>Serogroup C Class-Specific Antibody Concentrations and Bactericidal Titers in Sera from Young Children from Montana Immunized with a Licensed Polysaccharide Vaccine (1998)

Neisseria meningitidis serogroup C bactericidal titers and class-specific enzyme-linked immunosorbent assay (ELISA) antibody concentrations were measured in sera from 173 children (1 to 5 years old) before and 6 weeks and 7 months following vaccination with a quadrivalent (A/C/Y/W-135) polysaccharide vaccine. The immune responses of the children were compared with those of 40 adults 6 weeks postvaccination. Both bactericidal titers and ELISA antibody concentrations were significantly higher in the adults than in the children (P < 0.05). In addition, the ratio of immunoglobulin G (IgG) to IgM was higher in the children than in the adults. With an ELISA total antibody concentration of >/=2 microg/ml used as a measure of seroconversion, >/=84% of the individuals from each age group responded to the serogroup C polysaccharide. However, with a >/=4-fold-increase in bactericidal titer used, only 18% of 1-year-olds, 32% of 2-year-olds, and 50 to 60% of 3-, 4-, and 5-year-olds seroconverted. The ELISA results suggest that >50% of all children retained >/=2 microg of total antibody per ml at 7 months postimmunization. However, the bactericidal titers suggest that <10% of children <4 years old retained a >/=4-fold increase at 7 months following vaccination. Of particular note, 59 of 79 sera (75%) from the 1- and 2-year-olds had high ELISA antibody concentrations (2 to 20 microg/ml) with no associated bactericidal titer (<1:8). Discordant results between bactericidal titers and ELISA antibody concentrations were not explained by the presence of IgA blocking antibody or relative levels of IgG and IgM. The bactericidal results show age-dependent differences in the production and retention of antibody in young children immunized with serogroup C polysaccharide; these differences are not evident with the ELISA data.
A Green Deep Eutectic Solvent-Based Ultrasound-Assisted Method to Extract Astaxanthin from Shrimp Byproducts (2014)

The extraction of valuable compounds from waste products using green and inexpensive solvents is a significant strategy for sample preparation. Accordingly, in the present study, the use of deep eutectic solvents, an emerging green approach, was used to extract astaxanthin, a well-known and widely-used antioxidant, from shrimp byproducts. After evaluating different combinations of extraction conditions and deep eutectic solvents, an ultrasonication method was established and optimized by a systematic investigation of the influencing factors. A comparison of the amount of astaxanthin (102 μg g− 1 ) extracted using a traditional organic solvent, ethanol, showed that more astaxanthin (146 μg g− 1 ) was obtained using the reported eco-friendly method. The excellent properties of deep eutectic solvents highlight their advantages as promising inexpensive green solvents for the extraction and determination of a range of bioactive compounds from natural products.
A Bi-static Gregorian Confocal Dual Reflector Antenna for a bomb detection radar system (2007)

A bistatic Gregorian confocal dual reflector antenna for a bomb detection radar system had been presented. The beamwidth is suitable to uniquely illuminate a single human body at 50m away from the antenna. The dual reflector can be used for both transmit and receive simultaneously. The Configuration-1 behaves better than Configuration-2 in terms of directivity whereas it become worst in terms of crosspolar levels.
Lymphocytes: Intraepithelial (2009)

Abstract Intraepithelial lymphocytes (IEL) are small, round mononuclear immune cells, which reside in the paracellular space between nonimmune epithelial cells. They are found in the skin and within the epithelial layer that lines the intestine, the biliary tract, the oral cavity, the upper respiratory tract and lungs and the reproductive tract. The largest population of IEL resides within the epithelium of the small intestine where they form the first line of immune defence against invading pathogens while preserving the integrity of the mucosal barrier. Key concepts The lymphocytes located in the epithelium are at the frontline between the self and nonself. The T‐cell populations from the small intestine are the most important in number and the most diverse in the body. The T‐cell populations from the epithelium often contain unconventional subpopulation such as CD8aa TCRab+ IEL in the intestine. Introduction of the new concept of agonist selection for self‐specific CD8aa TCRab+ IEL. Important function of IEL during immune response against pathogens.
Ballistics-Electron-Microscopy and Spectroscopy of Metal/GaN Interfaces (1997)

BEEM spectroscopy and imaging have been applied to the Au/GaN interface. In contrast to previous BEEM measurements, spectra yield a Schottky barrier height of 1.04eV that agrees well with the highest values measured by conventional methods.
Storage and restoring the electricity of renewable energies by coupling with natural gas grid (2013)

International audience
Low‐grade salivary duct carcinoma in the bronchus (2015)

Contains fulltext : 170906.pdf (Publisher’s version ) (Open Access)
Sticking probability of light hydrocarbons on tungsten (1969)

Hydrocarbons were decomposed on the surface of an incandescent tungsten filament in a low pressure flow reactor. The rate of conversion of tungsten to ditungsten carbide W2C was measured by a resistance method. Carbon accumulation on the outer W2C surface was prevented by rapid inward diffusion. The sticking probability γ was defined as the probability that a room temperature hydrocarbon molecule striking the hot W2C surface would undergo complete decomposition to carbon and hydrogen. The value of γ for different hydrocarbons, measured over a 300-fold range of conversion rates, increased in the order: methane<propane≃cyclopropane<neopentane. Mixing of hydrogen gas with the hydrocarbon reactant markedly increased γ. For example, at a filament temperature of 2610°K, γ increased from 6.4 × 10–3(methane only) to 2.6 × 10–2(methane plus hydrogen). This novel effect is explained by carbon patches on the W2C surface. These patches are associated with low values of γ but can be removed by adsorbed hydrogen.