gebhart/patrepeval huggingface dataset:
Associations between single nucleotide polymorphisms (SNPs) in inflammation-related genes and quality of life after radiation therapy (RT) for prostate cancer. (2013)

2 Background: Prostate-directed RT results in local inflammation that may contribute to short-term toxicity and subsequently effects on long-term quality of life (QOL). We sought to explore the hypothesis that SNPs in inflammation-related genes may influence QOL sequelae following definitive prostate cancer RT. Methods: We studied Caucasian participants in the prospective US Physicians’ Health Study diagnosed and treated with RT for non-metastatic prostate cancer between 1982 and 2006. Forty-three SNPs in 10 inflammation-related genes were genotyped and analyzed using the additive model. Men were followed for cancer-specific QOL outcomes with regularly administered questionnaires. We dichotomized the maximum score for four parameters (decreased urinary stream, increased urinary frequency, rectal urgency and impotence) relevant to RT reported at least one year following RT and analyzed associations between scores and SNPs using Fisher’s exact tests and logistic regression. Results: We identified 264 men with QOL data who previously provided blood for genotype analysis and received RT at a median age of 72 years (IQR 68 – 76 years). Features at diagnosis included: 67% PSA<10, 61% Gleason<7, 95% T1/T2 disease and 71% Charlson co-morbidity index 0-1. QOL questions were completed a median of 6 years following RT. Without adjusting for multiple testing, 13 SNPs had nominally significant associations (p < 0.05) with QOL parameters; 7 remained significant after adjusting for age, features at diagnosis, and use of brachytherapy (Table). Conclusions: We identify candidate SNPs in inflammation-related genes that can be further explored in regards to their associations with long-term effects of prostate-directed RT. [Table: see text]
Receptor‐receptor link in membranes revealed by ligand competition: Example for dopamine D1 and D2 receptors (1994)

An interaction or link between dopamine D1 receptors and dopamine D2 receptors was found by a ligand competition method, using [3H]raclopride to label dopamine D2 receptors and SCH 23390 to block dopamine D1 receptors. In the presence of endogenous or exogenous dopamine, SCH 23390 increased the binding of [3H]raclopride in post-mortem human striata homogenates or in tissue culture cells containing human dopamine D1 and D2 receptors. In order to reveal such intramembrane receptor-receptor interactions in general, therefore, it appears essential to add two agonists, one for each receptor, and then to block one of the receptors when measuring the binding of a ligand to the second receptor.
Diels‐alder cycloadditions of <i>N</i>‐substituted‐1,2‐dihydropyridines with 1,2,4‐triazoline‐3,5‐diones and maleimides (1976)

Abstract The reaction of N ‐substituted‐1,2‐dihydropyridines 1 with 1,2,4‐triazoline‐3.5‐diones 2 and maleimides 9 proceeds stereospecifically to afford endo cycloaddition products. N ‐Acetyl‐1,2‐dihydropyridines react with 2 to afford a stereo isomeric mixture of 3 and 4 whereas those possessing a N ‐ethoxycarbonyl, methoxycarbonyl, methanesulfonyl or benzenesulfonyl substituent yield 3 exclusively: similar results are also obtained in reactions employing maleimides. Stereochemistry was assigned on the basis of nmr data and use was made of the anisotropic effects of the 7,8 unsaturation on the R 1 and R 2 substituents.
Frequency locking at 50-GHz spacings using optoelectronic mixing in photoheterojunction bipolar transistors (1999)

We describe optoelectronic mixing in a photoheterojunction bipolar transistor to frequency lock two single-mode lasers at a frequency spacing of 50 GHz. We demonstrate high locking stability with an uncertainty in the detuning frequency of only a few megahertz.
Diborative Reduction of Alkynes to 1,2-Diboryl-1,2-Dimetalloalkanes: Its Application for the Synthesis of Diverse 1,2-Bis(boronate)s (2019)

Reduction of alkynes with alkali metals in the presence of B<sub>2</sub>pin<sub>2</sub> results in diboration of alkynes. Distinct from conventional dissolving metal hydrogenations, two carbon-boron bonds and also two carbon-alkali metal bonds can be constructed in one operation to form 1,2-diboryl-1,2-dimetalloalkanes. The 1,2-diboryl-1,2-dimetalloalkanes generated are readily convertible to a wide range of vicinal bis(boronate)s. In particular, oxidation of the 1,2-dianionic species provides ( E)-1,2-diborylalkenes, unique anti-selective diboration of alkynes being thus executed.
Akathisia as a risk factor for suicide (2006)

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ChemInform Abstract: A General [3 + 2 + 1] Annulation Strategy for the Preparation of Pyridine N‐Oxides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
OBSERVATIONS AND MAGNETIC FIELD MODELING OF THE FLARE/CORONAL MASS EJECTION EVENT ON 2010 APRIL 8 (2011)

We present a study of the flare/coronal mass ejection event that occurred in Active Region 11060 on 2010 April 8. This event also involves a filament eruption, EIT wave, and coronal dimming. Prior to the flare onset and filament eruption, both SDO/AIA and STEREO/EUVI observe a nearly horizontal filament ejection along the internal polarity inversion line, where flux cancellations frequently occur as observed by SDO/HMI. Using the flux-rope insertion method developed by van Ballegooijen, we construct a grid of magnetic field models using two magneto-frictional relaxation methods. We find that the poloidal flux is significantly reduced during the relaxation process, though one relaxation method preserves the poloidal flux better than the other. The best-fit pre-flare NLFFF model is constrained by matching the coronal loops observed by SDO/AIA and Hinode/XRT. We find that the axial flux in this model is very close to the threshold of instability. For the model that becomes unstable due to an increase of the axial flux, the reconnected field lines below the X-point closely match the observed highly sheared flare loops at the event onset. The footpoints of the erupting flux rope are located around the coronal dimming regions. Both observational and modeling results support the premise that this event may be initiated by catastrophic loss of equilibrium caused by an increase of the axial flux in the flux rope, which is driven by flux cancellations.
Topical Recombinant Alpha1-Antitrypsin: A Potential Treatment for Netherton Syndrome? (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Synergistic Costimulation by Both B7 Molecules Regulates Colitis Pathogenesis (2006)

It has been reported that B7-1 and B7-2 play different roles in the pathogenesis of autoimmunity, but this issue is controversial. Here we analyzed colitis induced by transfer of CD45RB(high) CD4+ T cells to immune-deficient recipients that lack expression of either B7-1 or B7-2. Surprisingly, disease was greatly accelerated in Rag(-/-) recipients deficient for either B7 molecule. Antigen presenting cells (APCs) lacking B7-1 or B7-2 stimulated T cell proliferation in vitro, but caused suboptimal IL-2 production, leading to decreased induction of CTLA-4. The data suggest that regulatory T cells function relatively normally in B7 single-deficient recipients, but they cannot restrain the increased pathogenesis by naïve cells primed in B7 single-deficient mice. Therefore, the inhibitory effect of CTLA-4 on pathogenic T cells likely slows colitis, even in the absence of regulatory T cells. While a full block of costimulation may prevent autoimmunity, our data indicate, surprisingly, that a partial block may in some cases augment disease.
SEROTYPING OF HUMAN ROTAVIRUS BY ENZYME IMMUNO-ASSAY WITH MONOCLONAL ANTIBODIES (1993)

Two series of enzyme immunoassays with monoclonal antibodies produced in two laboratories (A and B) were compared in use for serotyping of human rotavirus in stool samples collected in Japan between 1988 and 1991 from patients with gastroenteritis. Of 358 samples, 222 were determined to be the same serotype, while 61 samples could not be serotyped by either assay. A hundred and one and 92 samples were not serotyped by the A and B antibodies, respectively. We believe that the A and B monoclonal antibodies are useful clinically for serotyping rotaviruses at the present time.
Pyelovenous backflow or veno-caliceal valve fistula? (2007)

A 70-year-old male with urinary bladder carcinoma was admitted for follow-up. Retrograde pyelography demonstrated transfer of contrast medium into the left renal vein in two independent sessions. The absence of hematuria and a negative CT scan ruled out a classical veno-caliceal fistula. The presence of a veno-caliceal valve fistula into the left renal vein was hypothesized.
ChemInform Abstract: SYNTHESIS OF METALLACYCLOPENTANES CONTAINING TWO METALS IN THE RING. THERMAL DECOMPOSITION TO CYCLOPROPANE AND LIGAND‐INDUCED CONVERSION TO STABLE MONONUCLEAR METALLACYCLOPENTANONES (1980)

Abstract Während die Umsetzung des Radikalanions (II) mit MeI zur Bildung von (I) führt, bewirkt die Zugabe von 1,3‐Diiodopropan durch intramolekulare Dialkylierung die Bildung des stabilen Dimetallacyclopentans (III), das durch IR‐, NMR‐ und MS‐Daten charakterisiert wurde.
Design and Synthesis of Highly Potent and Selective Pharmacological Chaperones for the Treatment of Gaucher's disease (2006)

Remove to improve. Removal of the hydroxymethyl groups in 1 to give 2 significantly enhances inhibitory potency towards glucosylceramide β-glucosidase (GCase) and abolishes inhibition towards α-glucosidases. Xylitol 2 doubles the residual activity of GCase in fibroblasts from Gaucher patients at subinhibitory concentration (10 nM). This compound is therefore a promising candidate for the development of small-molecule drugs for the treatment of Gaucher's disease without the side effects associated with α-glucosidase inhibition.
NASA's Asteroid Redirect Mission (ARM) (2015)

Mission Description and Objectives: NASA's Asteroid Redirect Mission (ARM) consists of two mission segments: 1) the Asteroid Redirect Robotic Mission (ARRM), a robotic mission to visit a large (greater than approximately 100 meters diameter) near-Earth asteroid (NEA), collect a multi-ton boulder from its surface along with regolith samples, and return the asteroidal material to a stable orbit around the Moon; and 2) the Asteroid Redirect Crewed Mission (ARCM), in which astronauts will explore and investigate the boulder and return to Earth with samples. The ARRM is currently planned to launch at the end of 2021 and the ARCM is scheduled for late 2026.
A carbon-13 and proton magnetic resonance examination of solute structures, equilibriums, and structural interconversions in some dinuclear .eta.5-dienylruthenium, -iron, and -nickel carbonyls (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA carbon-13 and proton magnetic resonance examination of solute structures, equilibriums, and structural interconversions in some dinuclear .eta.5-dienylruthenium, -iron, and -nickel carbonylsOtto A. Gansow, Aaron R. Burke, and William D. VernonCite this: J. Am. Chem. Soc. 1976, 98, 19, 5817–5826Publication Date (Print):September 1, 1976Publication History Published online1 May 2002Published inissue 1 September 1976https://pubs.acs.org/doi/10.1021/ja00435a013https://doi.org/10.1021/ja00435a013research-articleACS PublicationsRequest reuse permissionsArticle Views239Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of human eosinophil lysophospholipase as the constituent of Charcot-Leyden crystals. (1980)

Since the initial descriptions of Charcot-Leyden crystals more than 100 years ago, the presence of these slender, dipyramidal crystals in human tissues and biologic fluids has become a hallmark of eosinophilic leukocyte infiltration, especially in association with allergic and helminthic diseases. The formation of these crystals in vitro after disruption of human eosinophils, but not of other cell types, in hypotonic saline or detergent established the eosinophil as the unique cellular source of the crystalline protein. Charcot-Leyden crystals have now been found to express lysophospholipase activity (lysolecithin acylhydrolase, EC 3.1.1.5), and the solubilized Charcot-Leyden crystal protein presents a single stained protein band that is coincident with the lysophospholipase activity eluted from replicate gels on alkaline polyacrylamide gel electrophoresis. On sodium dodecyl sulfate/polyacrylamide gel electrophoresis, the solubilized Charcot-Leyden crystal protein migrates with a molecular weight of 17,400, which is comparable to that of eosinophil lysophospholipase purified chromatographically to homogeneity; further, on combination, the two proteins comigrate as a single staining band. Finally, the chromatographically purified eosinophil lysophospholipase in hypotonic buffer forms dipyramidal crystals morphologically identical to Charcot-Leyden crystals. The findings that chromatographically purified, homogeneous eosinophil lysophospholipase and Charcot-Leyden crystal protein express the same enzymatic activity, are of the same size and charge, and form crystals of identical morphology indicate that human eosinophil lysophospholipase is the constituent of Charcot-Leyden crystals.
Well-Compensated Primary Bile Acid Malabsorption Presenting as Chronic Nonspecific Diarrhea (1986)

Increased fecal bile acid loss and defective in vitro ileal bile acid uptake were demonstrated in an 8-year-old boy with diarrhea starting in the neonatal period. His continuously normal physical development and good nutritional status are in keeping with a well-preserved cholic acid pool and normal duodenal bile acid concentration. Isolated bile acid malabsorption can remain well compensated and present as the chronic nonspecific diarrhea syndrome of childhood.
Integration of Commercial CAD With Commercial NC Programming Packages (2000)

Abstract This paper focuses on the issues in automating the various tasks in process planning and on the issues in integrating the process-planning task with commercial CAD/CAM software. Automated process planning involves two important tasks; machining feature extraction and feature-based process planning. The integration of CAD and NC may be done by two alternative approaches: external or internal. This study uses the external approach. The CAD model of the part and the stock is exported to a format compatible with the external geometry engine. The machining feature recognition system communicates with the external geometry engine through APIs to obtain geometric and topological information required for feature recognition. The machining knowledge embedded in the recognized features is used by the process-planner to chalk out a process plan for the part. The machining features are classified into three broad categories each with machining significance specific to NC machining, so that when extracted they are useful in making process-planning decisions. Setup Planning, Operation Sequencing and Tool Selection is performed automatically based on criteria such as feature shapes, feature locations, tool access directions and feasibility of workpiece locating and clamping. The detailed process planning is based on a commercial CAD/CAM/CAE package, I-DEAS.
Pathogenesis of the Type 2 Variant of the Syndrome of Apparent Mineralocorticoid Excess* (1990)

The syndrome of apparent mineralocorticoid excess, which is not a primary disorder of the adrenal cortex, describes the association of an unexplained hypermineralocorticoid state with a decreased rate of peripheral 11 beta-hydroxydehydrogenation of cortisol to cortisone. Studies in this syndrome have led to the hypothesis that peripheral cortisol inactivation is the normal mechanism permitting specific mineralocorticoid recognition. This view reconciled developing evidence that the mineralocorticoid receptor itself could not distinguish between mineralocorticoids and glucocorticoids. The syndrome occurs in two forms. In both forms there is decreased turnover of a normal level of plasma cortisol, consistent with the view that delayed removal of the glucocorticoid from strategic receptor sites unmasks its potential mineralocorticoid agonism. In the type 1 variant, impaired 11 beta-hydroxydehydrogenation is reflected by an elevated cortisol/cortisone metabolite ratio. In three patients with the type 2 variant, this ratio was normal, suggesting that the rate of 11 beta-hydroxydehydrogenation was unimpaired. The hypertension and hypokalemic alkalosis of both forms are improved by spironolactone, but patients with the type 2 variant have responded somewhat better to the suppression of cortisol by dexamethasone.
Scanning pupil tolerancing (2014)

The method proposed in this paper focuses on tolerancing to meet system performance, not the fight against the surface fingerprint of a particular fabrication process.
Studies on the Use of a Long-Acting Oxytetracycline in Turkeys: Serum Levels and Tissue Residues Following Injection (1985)

Forty 6-week-old large white commercial turkeys were injected subcutaneously with a long-acting oxytetracycline formulation (69 mg/lb). The turkeys were divided into four groups of 10 birds each, and the birds in each group were bled twice at different times between 4 and 144 hours postinjection (PI) to determine serum levels of oxytetracycline. Two additional groups of turkeys were also given the long-acting oxytetracycline formulation mixed with either neomycin or a bacterin for Pasteurella multocida to determine if either of these compounds interfered with absorption of the oxytetracycline. Serum levels of oxytetracycline were 5.38 micrograms/ml, 1.59 microgram/ml, and 0.93 microgram/ml at 24, 48, and 72 hours PI, respectively, following an average dose of 69 mg/lb of body weight. These levels are all considered therapeutic. There appeared to be no interference with absorption of oxytetracycline when mixed with either neomycin or the bacterin. Tissue residues of oxytetracycline in the muscle, liver, and kidney were within tolerance levels by 3 weeks PI.
Aqueous humor factors and their effect on the immune response in the anterior chamber (1990)

The immune response to antigens within the anterior chamber is deviant (anterior chamber associated immune deviation - ACAID) in that delayed hypersensitivity is deficient, whereas other immune effector modalities are intact. Experimental evidence indicates that the eye itself is critical to the induction of ACAID. We have examined the antigen processing and presenting potential of cells within the anterior segment of the eye, and have analyzed the potential immunoregulatory properties of these cells, their secretory products, and the aqueous humor itself. Evidence indicates that bone marrow-derived cells within the stroma of the iris and ciliary body inhibit antigen-driven T lymphocyte activation, although they themselves lack the capacity to present antigens to T lymphocytes. The mechanism is in part through secretion of immunosuppressive cytokines. Since aqueous humor contains similar cytokines, it is inferred that these molecules are constitutively secreted. We have determined that a major inhibitory molecule within normal aqueous humor is transforming growth factor-beta (TGFB), which inhibits antigen processing and presentation, and suppresses both T lymphocyte activation and certain aspects of non-specific inflammation. These effects also turn out to be properties of normal aqueous humor. These findings support the hypothesis that local features of the eye modify intraocular antigens such that an ACAID-inducing signal is produced. Experimental evidence suggests that these same properties may play a major role in suppressing efferent immune responses in the eye.
Correction - Synthesis and Optical Properties of Asymmetric Polyamides Derived from Optically Active Cyclic Dicarboxylic Acids (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection - Synthesis and Optical Properties of Asymmetric Polyamides Derived from Optically Active Cyclic Dicarboxylic AcidsC. G. Overberger and Y. ShimokawaCite this: Macromolecules 1972, 5, 5, 662Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/ma60029a031https://doi.org/10.1021/ma60029a031research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts