gebhart/patrepeval huggingface dataset:
Proposal and evaluation of models for the glottal source waveform (2005)

Speech analysis for high quality speech synthesis or high accuracy speech recognition requires realistic models not only for the vocal tract but also for the voice source. In the present paper, we investigate models for the glottal volume velocity waveform. Previously proposed models are reviewed and classified according to their level of elaboration in expressing the glottal characteristics. A new model is then proposed which possesses all the important features of previously proposed models. A method is also described for simultaneously estimating the glottal source and vocal: tract parameters. Using this method, evaluation of glottal model parameters is carried out on real speech by varying the number of parameters in the proposed model. The results indicate the importance of detailed modeling of the period of glottal closure for accurate analysis.
Lateral distributed-feedback gratings for single-mode, high-power terahertz quantum-cascade lasers (2012)

We report on terahertz quantum-cascade lasers (THz QCLs) based on first-order lateral distributed-feedback (lDFB) gratings, which exhibit continuous-wave operation, high output powers (>8 mW), and single-mode emission at 3.3-3.4 THz. A general method is presented to determine the coupling coefficients of lateral gratings in terms of the coupled-mode theory, which demonstrates that large coupling strengths are obtained in the presence of corrugated metal layers. The experimental spectra are in agreement with simulations of the lDFB cavities, which take into account the reflective end facets.
Factors Affecting Microhardness of Ti/TiN Multilayer Films Deposited by Pulsed Bias Arc Ion Plating (2007)

Ti/TiN multilayer films were deposited on high-speed-steel (HSS) substrates using pulsed-bias arc ion plating. Orthogonal experiments were used to analyze factors affecting microhardness of the films. The results show that of all the pulsed bias related parameters including pulsed bias magnitude, duty ratio, frequency, and film geometry parameters including modulation period, TiN/Ti thickness ratio, and grain size of TiN, the pulsed bias magnitude is the major factor affecting the microhardness. The maximum microhardness of 34.1 GPa was obtained with pulsed bias magnitude 900 V, duty ratio 50%, frequency 30 kHz, and modulation period 84 nm.
DESIGN AND PERFORMANCE OF BIORETENTION BEDS FOR REMOVAL OF STORMWATER CONTAMINANTS (2012)

INTRODUCTION Bioretention basins hold a volume of water that is filtered through sandy soil and allowed to infiltrate into the subsoil or drained to an outlet (Figure 1). Originally, bioretention basins were intended as a site-scale tool to improve the quality of urban stormwater runoff, but they have a demonstrated impact on reduction of runoff volume and time of concentration. Therefore, the design of basins are complicated by a range of possible goals. Recharging groundwater, improving runoff water quality to maintain or restore aquatic ecosystem health, reducing peak storm flows, extending time of concentration, and reducing runoff volume to prevent channel erosion and sedimentation are all possible goal options. Only a few states have guidelines or regulations for bioretention basins. Furthermore, some existing state design requirements do not reflect the range of goals or the research demonstrating the design and performance of bioretention basins. For example, the Idaho Department of Environmental Quality recommendations were published in 2005 but based information from 1993 (IDEQ, 2005). The first section below considers the original purpose—pollutant removal.
Chapitre - VIII - Les relations familiales (1998)

Les relations à l'intérieur des oustaux sont orchestrées en fonction de la place reconnue à chacun. La maisonnée est dirigée par le chef de famille, généralement le père, qui règne sur tous ceux qui cohabitent avec lui : conjoint ou descendants. Se pose alors la question du pouvoir du pater familias. Ce dernier s’avère indéniablement limité, soit parce que le maître est contesté en raison de sa démence ou de sa prodigalité, soit parce qu'il renonce partiellement à son commandement par le biai...
Development and application of the RF-driven Ion source (2003)

RF driven ion sources have been developed at the Lawrence Berkeley National Laboratory for more than a decade.This type of ion source can be operated with 2 or 13.5 MHz in either cw or pulsed mode for positive or negative ion beam production.In order to achieve long-life and reliable operations, various ion source and RF antenna configurations have been investigated.Application of the RF ion source includes spallation neutron source, ion implantation, ion beam lithography, focused ion beam systems, BNCT and brachytherapy and intense neutron generators.The latest RF driven ion source technology will be presented.
Introduction to Nanofiber Materials (2014)

Presenting the latest coverage of the fundamentals and applications of nanofibrous materials and their structures for graduate students and researchers, this book bridges the communication gap between fiber technologists and materials scientists and engineers. Featuring intensive coverage of electroactive, bioactive and structural nanofibers, it provides a comprehensive collection of processing conditions for electrospinning and includes recent advances in nanoparticle-/nanotube-based nanofibers. The book also covers mechanical properties of fibers and fibrous assemblies, as well as characterization methods.
Execution replay of parallel programs (2002)

Debugging MIMD programs is often a delicate job. As a matter of fact, they can have different behaviors in successive executions. So, cyclic debugging is not applicable. To make it available for parallel programmers, we propose execution replay (full and partial) for our multi-threaded execution model, the communicating active components (CAC). CACs have been defined to implement parallel object-oriented languages. This work is part of the PVC/BOX project whose goal is a full parallel object-oriented environment. The execution replay mechanism is the basic tool for usable parallel debugging tools building.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
RABBIT POX (1935)

The epidemiological significance of age, race, sex, genetic constitution and physiological status were studied by means of a differential analysis of the mortality data derived from a devastating epidemic of rabbit pox and, with the exception of sex, were found to be factors of the utmost importance in the determination of susceptibility. Young animals were more susceptible than adults and although the most susceptible age varied with the epidemic phase, it corresponded in general with the period of weaning. The influence of physiological status was further indicated by the increased susceptibility incident to lactation. Racial variations in susceptibility were obscured by age factors in young animals, but were of profound importance in the adult population and formed the most significant feature of the analysis. A high degree of conformity was found in the susceptibility of racially related breeds, and this similarity in behavior increased with the proximity of relationship. Moreover, a study of the hybrids obtained from the crossing of pure breeds showed that two separable groups of hereditary factors were concerned in the determination of breed susceptibility, one group consisting of essential racial characters, the other of constitutional factors incorporated in the stock by chance association, and that the final expression of susceptibility or resistance was the result of their combined interaction.
Changes and Transitions in a Cultural Museum Library: Moving From Supporting Museum Staff to Providing Services to the General Public (2007)

On June 10th 2005 the Stephen & Sharon Zimmerman Resource Center and the Watanabe Family Library opened their doors to the public, as part of the new Nina Mason Pulliam Education Center at the Eiteljorg Museum of American Indians and Western\nArt. For the library, this event meant the end of a rather protracted journey and the beginning of a new adventure.
Deanol and methylphenidate in minimal brain dysfunction (1975)

Deanol, a putative acetylcholine precursor, has been used as a treatment for childhood hyperactivity for years. Efficacy has not been satisfactorily established, however. Seventy-four children referred for problems with learning, including many with hyperactivity, were screened for neurological or psychiatric illness, then given deanol, methylphenidate, or placebo in a double-blind fashion for 3 months. Maintenance dose for methylphenidate was 40 mg daily; for deanol, 500 mg. Behavior rating forms, reaction time, and a series of standard psychometric tests were given before and after treatment. Both drugs showed significant improvement on a number of tests; the pattern and degree of change differed slightly for the two. In this paradigm, deanol thus appeared to improve performance in children with learning and behavior disorders. The mechanism of action remains speculative; proof that deanol increases acetylcholine is scanty, and there is a theoretical basis for actually assuming an anticholinergic effect. Further clinical studies on deanol are indicated.
Conductive polymers : synthesis and electrical properties (1997)

Partial table of contents: Polyacetylene (S. Curran, et al.). Electrically Conductive Polyacetylene Copolymers (L. Leung). Synthesis and Properties of Processable Polythiophenes (K. Kaeriyama). Molecular Conductive Materials: Polythiophenes and Oligothiophenes (S. Hotta). Polythiophene and Polypyrrole Copolymers (R. Gumbs). Polyanilines (D. Trivedi). Silicon-Containing Thiophene Oligomers and Polymers: Synthesis, Characterization and Properties (J. Sauvajol, et al.). Conductive Polymer Blends and Composites (M.-A. De Paoli). Organometallic Conductive Polymers (H. Nishihara). Self-Doped Conductive Polymers (M. Abdou & S. Holdcroft). Index.
Fringe pattern analysis for optical metrology theory, algorithms, and applications (2014)

The main objective of this book is to present the basic theoretical principles and practical applications for the classical interferometric techniques and the most advanced methods in the field of modern fringe pattern analysis applied to optical metrology. A major novelty of this work is the presentation of a unified theoretical framework based on the Fourier description of phase shifting interferometry using the Frequency Transfer Function (FTF) along with the theory of Stochastic Process for the straightforward analysis and synthesis of phase shifting algorithms with desired properties such
A Note on Selecting the Better Material in a Paired Comparison Test Program (1974)

Abstract This note deals with the problem of selecting the better material using a sequential paired comparison test program for the case where individual comparisons are qualitative rather than quantitative (namely, where the test outcome for each paired comparison is stated in terms of a preference for A versus B, or vice versa). A simple K series test method strategy is suggested for the selection procedure, and a table is given for the probability that the better material is indeed selected using this strategy. The application of the probability table to the selection of the better material for the cases of nonsequential qualitative paired comparisons and quantitative paired comparisons is also discussed.
A scoping review of studies investigating hearing loss, social isolation and/or loneliness in adults (2021)

Further research is warranted to examine the influence that hearing interventions, in particular HAs, have on social isolation and/or loneliness, with a specific need to include people who identify as being socially isolated and/or lonely at baseline.
Testing ATM systems (1994)

Asynchronous transfer mode systems are noteworthy for their ability to transport different types of data over a variety of media and to do so at high speed. Their speed and flexibility, however, make ATM systems hard to test. The author describes how the high bandwidth and unusual flexibility that make the asynchronous transfer mode so attractive also raise barriers to testing it.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Frequency stabilization of the helium-neon laser by saturated absorption in iodine vapour (1972)

Improvements in the frequency stability of the visible helium-neon laser are possible using saturated absorption in iodine vapour. Recent improvements in the design of these lasers are discussed, and the importance of third derivative locking methods in realizing the possible high reproducibility of the iodine reference frequencies is emphasized. Allan Variance measurements of the beat frequency between two stabilized lasers indicate a long term stability of better than 1 part in 1010.
New Web Browser Applications (2004)

Summarises new and developing Web browser technologies. Describes three browsers, one with a “tabbed browsing” capability, another which includes a new productivity tool called a “search information manager”, and a voice operated browser which is still in development.
Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators (2019)

Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or <i>ex vivo</i> manipulated autologous tissues, are the most used cellular source of cell therapy for a wide range of disorders. Due to the scarcity of matched donors and the difficulty of <i>ex vivo</i> expansion of HSCs, there is a growing interest in harnessing the potential of pluripotent stem cells (PSCs) as a <i>de novo</i> source of HSCs. PSCs make an ideal source of cells for regenerative medicine in general and for treating blood disorders in particular because they could expand indefinitely in culture and differentiate to any cell type in the body. However, advancement in deriving functional HSCs from PSCs has been slow. This is partly due to an incomplete understanding of the molecular mechanisms underlying normal hematopoiesis. In this review, we discuss the latest efforts to generate human PSC (hPSC)-derived HSCs capable of long-term engraftment. We review the regulation of the key transcription factors (TFs) in hematopoiesis and hematopoietic differentiation, the Homeobox (HOX) and GATA genes, and the interplay between them and microRNAs. We also propose that precise control of these master regulators during the course of hematopoietic differentiation is key to achieving functional hPSC-derived HSCs.
Cobalt(III)-promoted hydrolysis of amino acid esters and peptides and the synthesis of small peptides (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCobalt(III)-promoted hydrolysis of amino acid esters and peptides and the synthesis of small peptidesPaul A. Sutton and David A. BuckinghamCite this: Acc. Chem. Res. 1987, 20, 10, 357–364Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/ar00142a001https://doi.org/10.1021/ar00142a001research-articleACS PublicationsRequest reuse permissionsArticle Views650Altmetric-Citations122LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adhesion and biofilm formation of <i>Candida albicans</i> on native and Pluronic-treated polystyrene (2005)

Candida albicans forms part of the normal human flora whose growth is usually restricted by the normal flora bacteria and the host's immune system. It is an opportunistic fungal pathogen that causes infections in immunocompromised individuals, mechanical trauma victims and iatrogenic patients. Candida albicans can ingress the human host by adhering to a plastic surface (i.e. prosthetic devices, catheters, artificial organs, etc.) that is subsequently implanted, and forms a protective biofilm that provides a continuous reservoir of yeast to be hematogenously dispersed. In order for the medical profession to battle device-related infections, initial adhesion and biofilm formation of C. albicans needs to be better understood. There has been some skepticism as to whether the initial adhesion events bear any relationship to subsequent biofilm formation. Thus, to better comprehend the relationship between the initial adhesion rates and growth rate and biofilm formation, these events were studied on two different, well-defined culture surfaces, native polystyrene and Pluronic F127-conditioned polystyrene. The adhesion studies determined that Pluronic F127 adsorption dramatically reduced the adhesion of C. albicans to polystyrene. The biofilm growth studies, analyzed by confocal scanning laser microscopy, revealed that Pluronic F127 decreased the biofilm surface coverage, cluster group size, thickness and the presence of hyphal elements over the untreated polystyrene. These findings indicate that the effect of a material's surface chemistry on the initial adhesion process has a direct influence on subsequent biofilm formation.
Synthesis, structure and electrical behaviour of lanthanum-doped barium stannate (2004)

A few samples in the system Ba1−xLaxSnO3 (up to x ⩽ 0.15) have been synthesized via the solid state ceramic route. Powder x-ray diffraction pattern of the samples confirm the formation of a single phase solid solution only in the samples with x up to ⩽0.05. It was found that single phase compositions have a cubic crystal structure similar to that of undoped barium stannate. The ac electrical and dielectric properties of single phase samples have been studied in the frequency range 10 Hz–5 MHz for temperatures ranging from 300 to 550 K. The conductivities (both ac and dc) and relaxation time (τ) exhibit two regions of temperature dependence, namely region I, which represents 300–420 K, and region II, which governs 420–550 K. Conduction and dielectric relaxation in both temperature regions are explained in terms of variable range hopping of electrons. Complex plane impedance analysis revealed that the specific conductivity of the grains is two orders of magnitude higher than that of the grain boundaries.
Smart Capacitive Biosensor Based on a Programmable System-on-Chip, Featuring a Novel Method for Improving the Performance of its Analog Blocks (2008)

The authors present a novel approach to perform the readout of a capacitive genetic sensor by using an impedance sensing technique. The proposed architecture is sufficiently simple for being fitted in an off-the-shelf programmable system on chip (PSoC <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> ) from Cypress semiconductors and yet powerful enough for measuring a great range of capacitance values (100 pF - 10 muF).
Docking and Molecular Dynamics Study on the Inhibitory Activity of Novel Inhibitors on Epidermal Growth Factor Receptor (EGFR) (2010)

EGFR is the cell-surface receptor. Its overexpression or overactivity has been associated with a number of cancers, including breast, lung, ovarian, and anal cancers. Many therapeutic approaches are aimed at the EGFR. A series of 2, 7-diamino-thiazolo [4,5-d] pyrimidine analogues are among the most highly potent and selective inhibitors of EGFR described to date. For in-depth investigation into the structural and chemical features responsible for the binding recognition mechanism concerned, as well as for exploring the binding pocket of these compounds, we performed a series of automated molecular docking operations. It was revealed that the binding site consisted of three main areas (P1, P2 and P3) composed of most of the hydrophobic amino acids able to accommodate the lipophilic arms of the compounds investigated. However, the solvent interface did not make much contribution to the binding of the inhibitors. The presence of residues Met793 and Asp855 may also be responsible for the binding recognition through H-bond interactions, with Phe856 through a T-shape π-π stacking interaction. The interaction model and pharmacophore of EGFR inhibitors were derived that can be successfully used to explain the different biologic activities of these inhibitors. Moreover, the docking results were quite robust as further validated by molecular dynamics. It is anticipated that the findings reported here may provide very useful information or clue for designing effective drugs for the therapeutic treatment of EGFR-related cancer.
The role of retinoic acid related orphan receptor alpha in age-related macular degeneration (2015)

Age-related macular degeneration (AMD) is a prevalent cause of vision loss and irreversible blindness that affects more than 11 million Americans. AMD is a multifactorial disease with a number of genetic, demographic, and environmental risk factors. Currently the etiology of AMD is still unclear and there are no effective cure for this devastating disease, but recent studies have demonstrated that RORA is a candidate gene involved in AMD pathophysiology. RORA is a critical regulator of multiple biological processes and has been implicated in various physiological processes including circadian rhythm, lipid metabolism, photoreceptor development, autism, and inflammation. Our current study will explore in depth the role of RORA in AMD. We will look at the effects of RORA in the retina of mice. Localization studies of retinal tissues obtained from mice with a conditional knockout of RORA in epithelial cells showed little effect of RORA on structural cells of the retina. However, there was a decrease in VEGF and TGF-B proteins in RORA knockout. This is an interesting finding because VEGF and TGF-B has an important function in angiogenesis and neovascularization which are pathophysiological effects of AMD. In addition, we will try to identify gene targets of RORA that have also been linked with AMD. By identifying the targets of RORA and discovering how RORA regulates these targets, we hope to better understand the role of RORA in AMD pathophysiology. ChIP-seq and software analysis of the data was performed to identify all genomic targets of RORA linked with AMD. A number of promising genes were found in both RORA and AMD networks. The next step of this study is to perform quantitative analysis of these genes and how their expression is affected by RORA. Also, we will perform additional conditional RORA knockout models in cone cells and developing retinal cells to further understand the role of RORA in the retina and AMD pathogenesis.