gebhart/patrepeval huggingface dataset:
Progesterone administration and progressive sleep apneas (1981)

Nine adult patients with obstructive sleep apnea syndrome were administered medroxyprogesterone acetate, 60 to 120 mg/day, and the effect of medroxyprogesterone on clinical symptoms and obstructive apneas during sleep was assessed. Four patients responded with resolution of daytime sleepiness, disappearance of pedal edema, and a decrease in the number of obstructive apneas during sleep. Cessation of therapy led to a return of daytime sleepiness in three and an increase in obstructive apneas in all four subjects. Two responders experienced side effects of alopecia or decreased libido. Before medroxyprogesterone therapy, responders were distinguished from nonresponders only by the presence of a significantly lower resting arterial oxygen tension during wakefulness. We characterize a subgroup of patients who benefit from medroxyprogesterone therapy by reducing obstructive apneas during sleep. (<i>JAMA</i>1981;245:1230-1232)
Application of X-rays to nanolithography (1997)

The development of a successful fabrication process for electron devices with dimensions in the sub-100-nm domain will require a form of a high-resolution and high-volume patterning. In this paper we discuss the extensibility of X-ray lithography to this domain in terms of the resolution of the technique, considering in detail the effect of diffraction and photoelectrons. We show that optimized masks and exposure systems can deliver with relative ease patterning in the 70-50-nm region, while phase-shifting techniques can extend the resolution to sub-40 nm. High volume is provided by the use of the mask. The challenge remains in the fabrication of the IX mask, and in the achievement of the necessary placement accuracy.
Isolation and Characterization of Nervous Tissue Proteoglycans (2003)

Nervous tissues contain a variety of proteoglycans (, , ). In tissues,proteoglycans are present predominantly in extracellular matrices and on cell surfaces.Proteoglycans in extracellular matrices are generally extracted in soluble fractions by physiological buffers without detergents, whereas cell surface proteoglycans that are anchored to the plasma membrane either by transmembrane domains or glycosylphosphatidylinositol (GPI) linkages are fractionated into membrane fractions. Some proteoglycans in extracellular matrices requires chaotropic agents such as urea and guanidine for solubilization (). It has been shown that a total of 20 μg of proteoglycans (as protein) can be isolated from 1 g (wet weight) of embryonic rat brain tissues, in which 8 μg are from the soluble fraction and 12 μg are from the membrane fraction (). In the case of adult rat brain, a total of 35 μg of proteoglycans are isolated, 20 μg in the soluble fraction and 15 ng in the membrane fraction. In general, the soluble fraction contains predominantly chondroitin sulfate proteoglycans (CSPGs), whereas heparan sulfate proteoglycans (HSPG) are enriched in the membrane fraction.
Choice of control of sulfur and/or nitrogen deposition based on critical loads (2010)

为了设计更多的合理、有效的酸免职，控制政策，批评负担功能(CLF ) 被建立，一个二维的批评负担功能人物基于不变的集体平衡(SMB ) 被吸引方法。数字能被划分成五个不同区域：批评负担区域(非控制区域) ， S 免职控制区域， N 免职控制区域， S 和 N 免职选择控制区域和 S 和 N 免职同时的控制区域。根据免职点掉落了进的区域，我们能选择相应控制途径。与在中国的高基础的阳离子免职(BCdep ) 的进一步的考虑，三维的批评负担函数表面能被作为一个变量拿 BCdep 拉。作为案例研究，批评为在广州的含有红土的红地球的大量硫和氮与数据由领域采样和实验室分析获得了的当前的免职数据，植被数据和土壤被计算。结果证明当前的免职点在引起掉进 S 免职控制区域的免职点的 BCdep 掉进批评负担区域和 75% 减小，它显示了控制硫免职的重要性。当考虑滋养的氮的批评负担时，当前的免职点掉进 N 免职控制区域并且与 BCdep 的减小，免职点进入了 S 和 N 免职同时控制区域，它意味着硫和氮免职应该同时被控制。
Roles of lignin biosynthesis and regulatory genes in plant development (2015)

Lignin is an important factor affecting agricultural traits, biofuel production, and the pulping industry. Most lignin biosynthesis genes and their regulatory genes are expressed mainly in the vascular bundles of stems and leaves, preferentially in tissues undergoing lignification. Other genes are poorly expressed during normal stages of development, but are strongly induced by abiotic or biotic stresses. Some are expressed in non-lignifying tissues such as the shoot apical meristem. Alterations in lignin levels affect plant development. Suppression of lignin biosynthesis genes causes abnormal phenotypes such as collapsed xylem, bending stems, and growth retardation. The loss of expression by genes that function early in the lignin biosynthesis pathway results in more severe developmental phenotypes when compared with plants that have mutations in later genes. Defective lignin deposition is also associated with phenotypes of seed shattering or brittle culm. MYB and NAC transcriptional factors function as switches, and some homeobox proteins negatively control lignin biosynthesis genes. Ectopic deposition caused by overexpression of lignin biosynthesis genes or master switch genes induces curly leaf formation and dwarfism.
A Discussion of the Water Resources of the Metropolitan San Antonio Region (1972)

Abstract The history of the San Antonio region has been closely associated with water. Early settlements were located in the San Antonio River valley because of the excellent supply of water. San Antonio is the largest city in the United States which depends entirely upon ground water for its water supply. One of the region’s major aquifers, the Edwards and associated limestones, is the only source of water for approximately 1,000,000 people in the region. The geology of the Edwards and associated limestones is presently the subject of an intensive, multi-agency study. The ground water supply for the southern portions of the San Antonio region is derived from several aquifers, the major aquifer being the Carrizo-Wilcox aquifer. The Carrizo-Wilcox aquifer has been intensively developed for agriculture purposes during the past two decades. At the present time, there are no surface water supplies for domestic and industrial demands in the San Antonio region. Medina Lake is a privately owned (Bexar, Medina, Atascosa Water District) irrigation water reservoir, while Canyon Lake is primarily a flood retardation, conservation reservoir which supplies some downstream users by releases to the stream. The Edwards and associated limestones aquifer and Carrizo-Wilcox aquifer, with proper development and protection, can supply the majority of the water demands in the region for the near future. However, with ever increasing demands for water in the region, alternative sources of water must be developed in the immediate future. These alternative sources include sewage recycling, reuse, recharge and the development of surface water resources in the San Antonio region.
A piebald family. (2012)

Piebaldism is an uncommon congenital hypomelanotic disorder characterized by a white forelock and vitiligo like amelanotic macules. We report a family with piebaldism affecting four successive generations. The disease was present in 16 members of the family.
Laser fusion target illumination system (1975)

Laser fusion experiments require the focusing of very intense pulsed laser beams onto very small fuel pellets. All reported experiments to date have used lenses to focus one or more laser beams onto the target. This paper describes a combined refractive/reflective illumination system that provides nearly uniform irradiance with nearly orthogonal incidence over the complete spherical target, with only two laser beams. This illumination system was used in the experiments that produced the first known symmetric target implosions. Furthermore, these experiments produced what we believe were the first thermonuclear neutrons generated by a laser-driven implosion.
Mushin and learning in and beyond budo (2014)

Recent developments in the theorization of learning reflect a degree of frustration with the limitations of Western dualism and, in particular, with its separation of mind from body. These include the appropriation of the Buddhist concept of mindfulness in Positive Psychology and the concept of flow that has been applied to thinking about athlete performance in sport. This article follows on from this work to draw on the Japanese concept of mushin that underpins the practice of traditional martial arts and other cultural practices in Japan to explore the possibilities it offers for an holistic conception of learning. Translated by Suzuki as meaning ‘no mind’ in English, mushin describes a state reached through extended periods of training in which purity of action is made possible through the elimination of the interference of the conscious mind as a state of the unity of mind body and spirit. This article concludes by suggesting that the concept of mushin offers a new way of conceptualizing learning in and through sport that supports more holistic thinking about it. © Idōkan Poland Association “IDO MOVEMENT FOR CULTURE. Journal of Martial Arts Anthropology”, Vol. 14, no. 3 (2014), pp. 42–48 DOI: 10.14589/ido.14.3.6
The Saab Jig: An Aid in High Tibial Osteotomy (1978)

To increase the precision of high tibial osteotomy a surgical tool has been developed. The instrument is described. The precision obtainable using the instrument is found to be significantly (P < 0.001) higher than that obtained when operating without the instrument.
Genetic defects of iron transport. (1976)

Five genetic traits in man and laboratory animals have major effects on iron transport. The heterogeneous condition, hemochromatosis, in some families appears to segregate as a Mendelian trait, and is associated with defective control of intestinal iron absorption. In the very rare human autosomal recessive trait, atransferrinemia, there is an almost total lack of transferrin and gross maldistribution of iron through the body. In mice, sex-linked anemia (an X-linked recessive trait) causes iron deficiency through defective iron absorption, at the "exit" step; a similar defect probably exists in placental iron transfer. In microcytic anemia of mice, an autosomal recessive trait, iron absorption is also impaired because of a defect of iron entry into cells, which is probably generalized. Belgrade rat anemia, less understood at present, also may involve a major disorder of iron metabolism. Study of these mutations has provided new knowledge of iron metabolism and its genetic control Their phenotypic interaction with nutritional factors, especially the form and quantity of iron in the diet, may provide new insights for the study of nutrition.
Alterations in chromatin are associated with increases in collagen III expression in aging nephropathy (2011)

Aging nephropathy is a slowly progressive fibrotic process that affects all compartments of the kidney and eventually impairs kidney function; however, little is known about the mechanisms that contribute to this process. These studies examined the epigenetic control of expression of collagen III (Col3a1), a matrix protein that contributes to kidney fibrosis. Using real-time PCR, Western blotting, and chromatin immunoprecipitation assay of kidneys harvested from 4- and 24-mo-old ad libitum-fed F344 rats, we found increased transcription of Col3a1 that was associated with increased RNA polymerase II recruitment despite elevated posttranslational histone modification (H3K27me3) normally associated with gene silencing. A reduction in the density of another repressive modification (H3K9me3) at the Col3a1 locus in aged rats suggests that cooperation between Polycomb- and heterochromatin-mediated systems are required to maintain repression of the Col3a1 gene. These findings demonstrate alterations in epigenetic control of gene expression in association with the fibrosis of aging nephropathy.
Influence of Hydrogen on Al-doped ZnO Thin Films in the Process of Deposition and Annealing (2009)

The Al-doped ZnO (AZO) films were deposited on a glass substrate by RF magnetron sputtering in pure Ar and <TEX>$Ar+H_2$</TEX> gas ambient at temperature of <TEX>$100^{\circ}C$</TEX> and annealed in hydrogen ambient at the temperature range from 100 to 300 <TEX>$^{\circ}C$</TEX>, respectively. It was found that either the addition of hydrogen to the sputtering gas or the annealing treatment effectively reduced the resistivity of the AZO films. When the AZO films were annealed at the temperature of 300 <TEX>$^{\circ}C$</TEX> for lhr in a hydrogen atmosphere, the resistivity decreased from <TEX>$2.60{\times}10^{-3}\;{\Omega}cm$</TEX> to <TEX>$8.42{\times}l0^{-4}\;{\Omega}cm$</TEX> for the film deposited in pure Ar gas ambient. Under the same annealing conditions of temperature and hydrogen ambient, the resistivity of AZO films deposited in the <TEX>$Ar+H_2$</TEX> gas mixture decreased from <TEX>$8.22{\times}l0^{-4}\;{\Omega}cm$</TEX> to <TEX>$4.25{\times}l0^{-4}\;{\Omega}cm$</TEX>. The lowest resistivity of <TEX>$4.25{\times}l0^{-4}\;{\Omega}cm$</TEX> was obtained by adding hydrogen gas to the deposition and annealing process. X-ray diffraction (XRD) pattern of all films showed preferable growth orientation of (002) plane. The average transmittance is above 85 % and in the range of 400-1000 nm for all films.
Nitrogen elimination from landfill leachates using an extra carbon source in subsurface flow constructed wetlands (2007)

A three-stage constructed wetland for leachate treatment was monitored on a landfill at a pilot scale. The plant had been designed to achieve at least 75% nitrogen removal. NH4-N input concentration was 240 (median) up to 290 mgl(-1) and COD concentration was 455 to 511 mgl(-1), respectively. A 14 m2 vertical flow sand filter plus a 14 m2 horizontal flow sand filter followed by a 3.3 m2 vertical flow sand filter was chosen. Acetic acid was added to the horizontal flow system for denitrification. The results showed a very stable nitrification rate within the vertical flow system of 94% (median) at NH4-N loading rates of about 10 (median) up to 17 gm(-2)d(-1). Denitrification was mainly dependent on the dosing of acetic acid and could reach a maximum of 98%. One interesting effect was the production of nitrite in the horizontal flow sand filter. This could efficiently be eliminated by the subsequent vertical flow sand filter. The chosen concept proved to be very effective for nitrogen removal. In combination with a final activated carbon filter the COD effluent concentrations could be easily and safely controlled. The design of denitrification reed beds showed a further potential for optimization.
Synthesis, crystal structures, electrochemical and protein-binding properties of ferrocene–indole conjugates (2006)

This paper describes the synthesis, characterisation and electrochemical properties of three redox-active ferrocene–indole compounds, N-(ferrocenylmethylenyl)tryptamine (Fc–CHNC2H4-indole) (Fc1), N-(ferrocenylmethyl)tryptamine (Fc–CH2NHC2H4-indole) (Fc2) and indole-3-(N-(6-(N-ferrocenylmethyl)aminohexyl))carboxamide (Fc–CH2NHC6H12NHCO-indole) (Fc3). The X-ray crystal structures of Fc1 and Fc2 have been investigated. The recognition of the redox-active ferrocene–indole compounds Fc2 and Fc3 by indole-binding proteins including bovine serum albumin and tryptophanase has been studied by electrochemical and luminescence titrations and enzyme inhibition assays.
Somatic motoneurone specification in the hindbrain: the influence of somite-derived signals, retinoic acid and Hoxa3 (2003)

We have investigated the mechanisms involved in generating hindbrain motoneurone subtypes, focusing on somatic motoneurones, which are confined to the caudal hindbrain within rhombomeres 5-8. Following heterotopic transplantation of rhombomeres along the rostrocaudal axis at various developmental stages, we have found that the capacity of rhombomeres to generate somatic motoneurones is labile at the neural plate stage but becomes fixed just after neural tube closure, at stage 10-11. Grafting of somites or retinoic acid-loaded beads beneath the rostral hindbrain induced the formation of somatic motoneurones in rhombomere 4 only, and Hox genes normally expressed more caudally (Hoxa3, Hoxd4) were induced in this region. Targeted overexpression of Hoxa3 in the rostral hindbrain led to the generation of ectopic somatic motoneurones in ventral rhombomeres 1-4, and was accompanied by the repression of the dorsoventral patterning gene Irx3. Taken together, these observations suggest that the somites, retinoic acid and Hox genes play a role in patterning somatic motoneurones in vivo.
ANTICLERICALISM IN THE GERMAN PEASANTS' WAR 1525 (1979)

ANTICLERICALISM IN THE GERMAN PEASANTS' WAR 1525 Get access Henry J. Cohn Henry J. Cohn University of Warwick Search for other works by this author on: Oxford Academic Google Scholar Past & Present, Volume 83, Issue 1, May 1979, Pages 3–31, https://doi.org/10.1093/past/83.1.3 Published: 01 May 1979
Dental health tourism in India (2014)

Medical tourism is patient movement from highly developed nations to other areas of the world for medical care, usually to find treatment at a lower cost. Medical tourism is different from the traditional model of international medical travel where patients generally journey from less developed nations to major medical centres in highly developed countries for medical treatment that is unavailable in their own communities. India stands out be one of leading destinations providing healthcare services along with other developing nations. While some patients benefit immensely from this industry, others are subjected to a number of complications and illegal practices. However, despite the conflicts of opinions, this industry is continuing to grow and is major source of income for some developing nations.
Frequency-Offset Self-Injection-Locked (FOSIL) Radar for Noncontact Vital Sign Monitoring (2020)

This paper presents a novel frequency-offset self-injection-locked (FOSIL) radar that uses up/down-mixers to combine two self-injection-locked (SIL) radars. By properly adjusting the injection phases and amplitudes, the transmit frequency of the proposed architecture is held constant, and the electromagnetic interference (EMI) issue associated with a conventional SIL radar is thus resolved, allowing multiple wireless devices to coexist within a limited bandwidth. Also, the Doppler sensitivity is improved by the up-converted transmit frequency of the radar. In the experiments, a 5.8 GHz ISM-band FOSIL prototype that was composed of 2.8 and 3.0 GHz SIL radars was used to detect a moving metal plate and a seated subject. The theoretical predictions and measurements were in good agreement.
An Intramolecular Signaling Element that Modulates Dynamin Function In Vitro and In Vivo (2009)

Dynamin exhibits a high basal rate of GTP hydrolysis that is enhanced by self-assembly on a lipid template. Dynamin's GTPase effector domain (GED) is required for this stimulation, though its mechanism of action is poorly understood. Recent structural work has suggested that GED may physically dock with the GTPase domain to exert its stimulatory effects. To examine how these interactions activate dynamin, we engineered a minimal GTPase-GED fusion protein (GG) that reconstitutes dynamin's basal GTPase activity and utilized it to define the structural framework that mediates GED's association with the GTPase domain. Chemical cross-linking of GG and mutagenesis of full-length dynamin establishes that the GTPase-GED interface is comprised of the N- and C-terminal helices of the GTPase domain and the C-terminus of GED. We further show that this interface is essential for structural stability in full-length dynamin. Finally, we identify mutations in this interface that disrupt assembly-stimulated GTP hydrolysis and dynamin-catalyzed membrane fission in vitro and impair the late stages of clathrin-mediated endocytosis in vivo. These data suggest that the components of the GTPase-GED interface act as an intramolecular signaling module, which we term the bundle signaling element, that can modulate dynamin function in vitro and in vivo.
The NPU System for the 2020 Personalized Voice Trigger Challenge (2021)

This paper describes the system developed by the NPU team for the 2020 personalized voice trigger challenge. Our submitted system consists of two independently trained subsystems: a small footprint keyword spotting (KWS) system and a speaker verification (SV) system. For the KWS system, a multi-scale dilated temporal convolutional (MDTC) network is proposed to detect wake-up word (WuW). For SV system, Write something here. The KWS predicts posterior probabilities of whether an audio utterance contains WuW and estimates the location of WuW at the same time. When the posterior probability ofWuW reaches a predefined threshold, the identity information of triggered segment is determined by the SV system. On evaluation dataset, our submitted system obtains detection costs of 0.081and 0.091 in close talking and far-field tasks, respectively.
Online outlier detection over data streams (2005)

Outlier detection is an important data mining task. Recently, online discovering outlier under data stream model has attracted attention for many emerging applications, such as network intrusion detection. Because the algorithms on data streams are restricted to fulfil their works with only one pass over data sets and limited resources, it is a very challenging problem to detect outliers over streams. In this paper, we present an unsupervised outlier detection approach to online network intrusion detection over data streams. Our method continuously maintains online summary and obtains a set of clusters, and those small clusters far away from big clusters are regarded as outlier clusters. We also propose a novel definition of outlier degree to measure the outlying degree of each cluster. When a new data arrives, it is considered as an outlier if it lies in the top-k outlier clusters. Experiment results demonstrate the effectiveness of our method.
Security specification of WS-SecureConversation (2015)

The usage of the internet consists of several fields e.g. business, social, government, education, and so on. In business, the internet is needed to connect producers with consumers. Consumers do not need to come to a place to buy some goods. Transactions can be done at home using an internet connection. One of the usage of Internet technology is a web service. The emerging of this technology as there is paradigm of virtual enterprise. This indicates that the company sees the fact in the performance of all its business processes externally but in practice it does not happen. So, not all business processes run in a company but most business processes are also executed in its partner. The usage of the web service also allows the emergence of the threat of another party. This threat can be the vulnerability of confidentiality and integrity of data. One of way to handle is to use WS-Security framework. This framework is a standard web service security based-on XML. However, it is lacking in a lot of message exchange and occurs in specified time. This deficiency can be overcome by using WS-SecureConversation framework. The testing resulted by message exchange for 100 times shows that process time of WS-SecureConversation is lower than WS-Security usage. The data integrity aspect is done by request message modification to result an error message. The data availability aspect is done by invalid accessing to available services, this occurrence emerges denied system to serve service request so data availability are valid user only.