gebhart/patrepeval huggingface dataset:
Terapia ocupacional domiciliaria en el ámbito de personas con lesión medular. Una revisión sistemática. (2016)

espanolObjetivo: analizar la situacion actual de la Terapia Ocupacional a domicilio en Espana y conocer las investigaciones llevadas a cabo en otros paises en el ambito de las personas con lesion medular. Metodos: se llevo a cabo una busqueda bibliografica, revisando buscadores de internet, bases de datos de Ciencias de la Salud y sitios web especificos de Terapia Ocupacional. Resultados: la evidencia recoge el rol del terapeuta ocupacional en la intervencion a domicilio describiendo todas sus funciones. Destaca la presencia de articulos relacionados con la accesibilidad del domicilio y los metodos de clasificacion de la intervencion. Conclusion: la Terapia Ocupacional a domicilio es un metodo de intervencion apropiado y eficaz. Actualmente hay algunas evidencias en aspectos relacionados con la accesibilidad en el hogar pero no en lo referente a la completa intervencion. EnglishObjective: to analyze the current situation of home¬based occupational therapy in Spain. To have a knowledge about the researches from the perspective of people with spinal cord injury in other countries. Methods: a literature search and bibliographic review have been done on health sciences databases, Internet search engines and Occupational Therapy specific websites. Results: evidence shows the role of the occupational therapist at home describing the intervention and his functions. There is a relevant presence of studies related to home accessibility and intervention classification methods. Conclusion: home-based Occupational Therapy is an appropriate and effective intervention method. Currently, there are some evidence on issues related to accessibility at home but not in terms of the complete intervention.
Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease (2013)

Isoprenoids and prenylated proteins have been implicated in the pathophysiology of Alzheimer disease (AD), including amyloid-β precursor protein metabolism, Tau phosphorylation, synaptic plasticity, and neuroinflammation. However, little is known about the relative importance of the two protein prenyltransferases, farnesyltransferase (FT) and geranylgeranyltransferase-1 (GGT), in the pathogenesis of AD. In this study, we defined the impact of deleting one copy of FT or GGT on the development of amyloid-β (Aβ)-associated neuropathology and learning/memory impairments in APPPS1 double transgenic mice, a well established model of AD. Heterozygous deletion of FT reduced Aβ deposition and neuroinflammation and rescued spatial learning and memory function in APPPS1 mice. Heterozygous deletion of GGT reduced the levels of Aβ and neuroinflammation but had no impact on learning and memory. These results document that farnesylation and geranylgeranylation play differential roles in AD pathogenesis and suggest that specific inhibition of protein farnesylation could be a potential strategy for effectively treating AD.
Helicobacter pylori gastritis and primary gastric non-Hodgkin's lymphomas. (1994)

These data support the hypothesis that H pylori has an important role in the development of MALT lymphomas. Furthermore, the chronic inflammation preceding malignant transformation might enhance the probability of malignant transformation via chronic stimulation of the lymphoid tissue. This might in part indicate why MALT lymphomas occur most often in the stomach.
Plasminogen Activator Inhibitor 1 and Plasminogen Activator Inhibitor 2 in Various Disease States (1988)

The association of increased PA-inhibitor (PAI) activity and of PAI-1 and PAI-2 antigen levels with different pathological conditions was studied in a collective of over 300 patients. PAI-1 and PAI-2 levels were measured by specific radioimmunoassays. A good correlation was observed of PAI activity with PAI-1 antigen (r = 0.718; p less than 0.0001) but not with PAI-2 (r = 0.070; n.s.). Both in the controls and in the patients, PAI activity and PAI-1 antigen showed an extremely large range of values. PAI activity ranged from 0.5 to 68 U/ml and PAI-1 antigen from 6 to 600 ng/ml. Increased PAI activity and PAI-1 antigen was observed in patients with malignant tumors, cardiovascular or thromboembolic disease, in the postoperative phase, with hepatic insufficiency, after trauma and after extracorporeal circulation. The large spectrum of disease states with increased PAI activity and PAI-1 antigen reinforces previous suggestions that PAI-1 is an acute phase reactant. After extracorporeal circulation, PAI activity and PAI-1 concentrations strongly increased within one hour, remained elevated for at least one week and returned to preoperation values within 7 days. PAI-2 values ranged from below detection limit (15 ng/ml), observed in half of the plasmas, to 485 ng/ml in a pregnant woman. High values of PAI-2 were only observed in pregnancy.
Illicit Drugs Policy: Legal and International Perspectives (2002)

The possible implications for Australia if the existing drug policy based on law enforcement is replaced by legalisation through reform are discussed. The drug policy in countries such as the Netherlands, Switzerland and Sweden are presented, and it is suggested that Sweden's drug policy could be adopted by Australia.
Average-Speed Forecast and Adjustment via VANETs (2013)

A wet road is slippery so vehicles often slow down their speed to increase the safety margin, thus usually reducing the average speed. This reduction in average speed may produce a chain reaction that shifts, extends, or amplifies a slowdown on downstream road segments. Conventional average-speed forecasting approaches are unable to respond to sudden chain reactions because these approaches do not consider the effect of weather factors and upstream road segments. Since accurate forecast of average speed can improve gas consumption, carbon dioxide emissions, and travel time, this paper proposes a short-term average-speed forecast and adjustment (ASFA) approach based on a study of prediction bias correlation among adjacent road segments and on weather factors, such as temperature, humidity, and rainfall. First, this approach applies an artificial neural network to predict the average speed of a road segment. Then, vehicles can monitor current traffic to calculate average speed via vehicular ad hoc networks (VANETs). Finally, the vehicles adjust the predicted average speed according to the observed average speed. Real traffic measurements and weather data are used for the evaluation of the proposed scheme and Civic Boulevard in Taipei City is selected as the prediction target. The results show that the proposed ASFA improves accuracy by 57.4% when compared with a hybrid approach on an urban street during rush hour. This paper estimates and simulates a case study by aggregating traffic data in 186 ms on Shi-Min Boulevard via the VANETs during rush hour.
Capacity of the circular plate condenser: analytical solutions for large gaps between the plates (2005)

A solution of Love's integral equation (Love E R 1949 Q. J. Mech. Appl. Math. 2 428), which forms the basis for the analysis of the electrostatic field due to two equal circular co-axial parallel conducting plates, is considered for the case when the ratio, τ, of distance of separation to radius of the plates is greater than 2. The kernel of the integral equation is expanded into an infinite series in odd powers of 1/τ and an approximate kernel accurate to is deduced therefrom by terminating the series after an arbitrary but finite number of terms, N. The approximate kernel is rearranged into a degenerate form and the integral equation with this kernel is reduced to a system of N linear equations. An explicit analytical solution is obtained for N = 4 and the resulting analytical expression for the capacity of the circular plate condenser is shown to be accurate to . Analytical expressions of lower orders of accuracy with respect to 1/τ are deduced from the four-term (i.e., N = 4) solution and predictions (of capacity) from the expressions of different orders of accuracy (with respect to 1/τ) are compared with very accurate numerical solutions obtained by solving the linear system for large enough N. It is shown that the approximation predicts the capacity extremely well for any τ ⩾ 2 and an approximation gives, for all practical purposes, results of adequate accuracy for τ ⩾ 4. It is further shown that an approximate solution, applicable for the case of large distances of separation between the plates, due to Sneddon (Sneddon I N 1966 Mixed Boundary Value Problems in Potential Theory (Amsterdam: North-Holland) pp 230–46) is accurate to for τ ⩾ 2.
Lagrangian Dual Decomposition for Joint Resource Allocation Optimization Problem in OFDMA Downlink Networks (2018)

This paper proposes an efficient method for joint power and subcarrier allocation in a multicell multiuser OFDMA downlink network. The joint optimization problem is formulated with the objective of maximizing the energy efficiency subject to the constraints on the quality of service in sum transmission rates for each cell and the total transmit power for the network. Due to intercell cochannel interferences and multiple variable coupling, the problem is intractable in its original form. To relax the difficulties in coordinating cochannel interferences, we introduce the tolerable interferences constraints for interference channels. To cope with the multiple variable coupling, we decompose the joint optimization problem into two iterative processes of user scheduling and a parametric convex optimization problem, where the energy efficiency is treated as the parameter and approached by bisection search. Then, by double dual decomposition, the parametric convex problem is transformed into Lagrangian dual problems at two levels of cells and subcarriers, and a decentralized solution is obtained in closed form. Based on the reformulations, an iterative subgradient algorithm is presented for approaching the joint optimization problem with acceptable complexity. Computer simulations are conducted to validate the proposed algorithm and examine the effects of various system parameters.
Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer (2009)

CD133 has been postulated to be a colon cancer stem cell (CSCs) marker. Recent investigations suggest that CSCs might contribute to cancer recurrence and resistance to conventional therapies. This study aimed to evaluate the role of CD133 in residual cancer cells after chemoradiotherapy (CRT) for rectal cancer. Forty patients with rectal cancer underwent CRT followed by surgery. Total RNAs of rectal cancer cells before (n=30) and after (n=40) CRT were isolated. Intratumoral CD133, vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) levels were measured using real-time reverse transcription polymerase chain reaction. Immunohistochemical staining of CD133 after CRT was also investigated. CD133 in residual cancer cells was higher than in stromal cells in post-CRT specimens (p<0.0001). The levels of CD133 were found to have increased in post-CRT specimens (p=0.0184), while VEGF and EGFR levels decreased during CRT (p<0.0001 and p=0.0002, respectively). Patients who developed distant recurrence had a higher post-CRT CD133 compared with those patients without recurrence (p=0.0136). Elevated post-CRT CD133 was associated with poor disease-free survival (p=0.0168). Immunohistochemical staining of the cytoplasmic and apical/endoluminal membranous CD133 was observed in residual cancer cells after CRT. CD133 expression in residual cancer cells after CRT may indicate a treatment resistant phenotype in putative CSCs. Elevated CD133, but not VEGF or EGFR, on FFPE specimens may be a predictive marker of distant recurrence and poor survival after preoperative CRT in rectal cancer.
A clinical review of phototherapy for psoriasis (2017)

Psoriasis is an autoimmune inflammatory skin disease. In the past several decades, phototherapy has been widely used to treat stable psoriatic lesions, including trunk, scalp, arms and legs, and partial nail psoriasis. A variety of light/lasers with different mechanisms of action have been developed for psoriasis including ultraviolet B (UVB), psoralen ultraviolet A (PUVA), pulsed dye laser (PDL), photodynamic therapy (PDT), intense pulsed light (IPL), light-emitting diodes (LED), and so on. Because light/laser each has specific therapeutic and adverse effects, it is important to adequately choose the sources and parameters in management of psoriasis with different pathogenic sites, severities, and duration of the disorder. This review aims at providing most updated clinic information to physicians about how to select light/laser sources and individual therapeutic regimens. To date, UV light is primarily for stable plaque psoriasis and PDL for topical psoriatic lesions with small area, both of which are safe and effective. On the other hand, PUVA has better curative effects than UVB for managing refractory psoriasis plaques, if its side effects can be better controlled. PDL provides optimal outcomes on nail psoriasis compared with other lasers. Although the trails of low-level light/laser therapy (LLLT) are still small, the near infrared (NIR) and visible red light with low energy show promise for treating psoriasis due to its strong penetration and encouraging photobiomodulation. IPL is rarely reported for psoriasis treatment, but PDT-IPL has been found to offer a moderate effect on nail psoriasis. In brief, various phototherapies have been used either in different combinations or as monotherapy. The modality has become a mainstay in the treatment of mild-to-moderate psoriasis without systemic adverse events in today's clinical practice.
Temperature influence on morphological progress of Ni(OH)2 thin films and its subsequent effect on electrochemical supercapacitive properties (2013)

The temperature dependent morphological evolution and its effect on the electrochemical supercapacitive properties of Ni(OH)2 thin films have been systematically investigated. A temperature dependent growth mechanism model is proposed for the changes in microstructure. Different nanostructures of Ni(OH)2 thin films such as nanoplates, stacked nanoplates, nanobelts and nanoribbons have been fabricated by varying the deposition temperature. An X-ray diffraction study discloses the orientations of different nanostructures and the formation of nanocrystalline β-Ni(OH)2. Further, these Ni(OH)2 nanostructures demonstrate excellent surface properties like uniform surface morphology, good surface area, pore volume and uniform pore size distribution. The electrochemical supercapacitive properties of Ni(OH)2 nanostructures have been investigated by cyclic voltammetry, charge–discharge and electrochemical impedance spectroscopy techniques. The electrochemical studies of the Ni(OH)2 samples show an obvious influence of surface properties on the pseudocapacitance. The maximum specific capacitance of 357 F g−1 was evaluated for nanoplates at a scan rate of 5 mV s−1. Furthermore, all these Ni(OH)2 samples show good long-term cycling performances in KOH electrolyte. The Ragone plots ascertain good power and energy densities of all Ni(OH)2 nanostructured samples. Subsequently, electrochemical impedance measurements for the different nanostructures of Ni(OH)2 electrodes are assessed indicating that the Ni(OH)2 nanoplates structured electrodes are suitable for good capacity electrochemical supercapacitors.
Effects of Existential Anxiety and Self-Esteem on the Perception of Others (1996)

Previous research has demonstrated that when people are led to think about death they later exhibit more polarized judgments of ingroup and outgroup members. This reaction has been interpreted as an attempt to defend against existential anxiety by seeing oneself as a secure member of a meaning-conveying cultural group. This study examined the moderating influence of self-esteem and found that the polarization effect in response to mortality primes was most pronounced for high self-esteem individuals. An additional manipulation of meaninglessness-anxiety was unsuccessful in producing polarization, lending support to the theoretical centrality of death concerns. We discuss the relevance of these findings to terror management theory (Solomon, Greenberg, & Pyszczynski, 1991).
Enhancing Instructor Capacity Through the Redesign of Online Practicum Course Environments Using Universal Design for Learning (2018)

A current trend in practicum or field experience programs is online and blended learning approaches being implemented alongside traditional classroom experiences. Principles of Universal Design for Learning (UDL) should be integrated in the design of these online environments in order to better support learning needs of all students. Instructors must also have confidence and competence in designing and facilitating learning within technology-enabled environments. This chapter reports on research conducted using design-based research to support instructor capacity development within field experience in a Bachelor of Education program. Three strategies are identified and discussed to enhance instructor's capacity: scaffolded support, modeling UDL practice in the online environment, and coaching to foster developing capacity using UDL. The chapter concludes by reporting on a new study that emerged as a result of this work, along with recommendations for practice.
Asymmetric Dimethyl Arginine and Cell Free Total DNA as Diagnostic Markers in Preeclampsia (2017)

This study was conducted to evaluate the predictive value of cell-free total DNA (cfDNA), asymmetric dimethyl arginine (ADMA) and compare between them in early diagnosis of preeclampsia (PE). This study was carried on twenty-five females with multiple pregnancies and had preeclampsia (preeclampsia group); they were admitted to obstetrics & gynecology department and followed by nephrologist or seen in nephrology & gynecology outpatient clinics of Al-Zahra University Hospital. Preeclampsia was diagnosed by the increased blood pressure ≥140 mm Hg systolic and ≥90 mm Hg diastolic measured on two occasions at least four hours apart accompanied by proteinuria—urinary excretion of more than 0.3g protein in a 24hr specimen. The control group consisted of age-matched twenty healthy pregnant women who had no medical problems, were normotensive throughout pregnancy and had neither proteinuria nor hyperuricemia (control group). All studied groups were subjected to full medical history, clinical examination, and laboratory investigations that include blood urea, serum creatinine, serum uric acid, 24 hr urinary protein, Cell-free DNA and ADMA. Results: there was highly significant increase in the level of ADMA, systolic blood pressure, and diastolic blood pressure in patient group compared with control group p value = (0.000) group. There was significant increase in total DNA levels in patient group than control group p value = (0.043). In our study we found significantly elevated level of serum creatinine and uric acid and urinary protein in preeclampsia group compared with control group. Also there was significant correlation between ADMA, total DNA levels and serum creatinine and proteinuria Value ( 0.291). Conclusions: cf DNA and ADMA are good predictor of diagnosis of PE and further studies for value of combining them may be promising.
Self-assembled monolayer modification of indium tin oxide anode surface for polymer light-emitting diodes with poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene vinylene] for high performance (2005)

We demonstrate that introducing a self-assembled monolayer (SAM) derived from 1,1,1,3,3,3-hexamethyldisilazane on an indium tin oxide (ITO) anode surface for the device (ITO/SAM/poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene vinylene]/Ca∕Al), can lead to an improvement in maximum device efficiency from 2.0to3.9cd∕A and maximum brightness from 33000to34400cd∕m2. Such improvement is even better than that with introducing a layer of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (2.6cd∕A and 16000cd∕m2), which is usually used as a hole transport (or injection) layer. The improvement results from a hole blocking effect and better wetting by converting the ITO surface from hydrophilic to hydrophobic provided by the SAM.
Development of monoclonal antibodies to rabbit ocular mucin. (1987)

Monoclonal antibodies against rabbit ocular mucin (ROM) and porcine stomach mucin (PSM) were developed to explore the biosynthesis and functional significance of ocular mucin. A nitrocellulose-based dot enzyme-linked immunosorbent assay (ELISA) was developed for hybridoma screening and mucin quantitation. The sensitivity was found to be at the level of 1 ng mucin per dot, which was about 1000 times more sensitive than that of our previously-reported histochemical method. Both anti-ROM and anti-PSM antibodies demonstrated specific bindings to rabbit conjunctival goblet cells and apical surface mucin of conjunctival epithelium by immunofluorescent and peroxidase-anti-peroxidase studies. These antibodies also showed specific bindings to ocular mucin and goblet cells of human conjunctiva on the impression cytology specimens obtained from normal subjects. These results indicate that these mucin-specific monoclonal antibodies can be used as a marker for goblet cell differentiation and as a probe to measure mucin content in the tear film and ocular surface. Selective loss of goblet cells and mucin deficiency were noted in impression cytology specimens of patients with various mucin-deficient disorders. This information indicates the potential application of these antibodies to study various ocular surface disorders characterized by alterations in goblet cell differentiation and mucin biosynthesis.
Interfacial and Surface Tensions of Polymers (1974)

Abstract Interfacial and surface tensions of polymers are important in the technology of plastics, coatings, textiles, films, and adhesives through their roles in the processes of wetting, adsorption, and adhesion. Because of experimental difficulty due to high viscosity, however, reliable measurements of these quantities were not reported until 1965 for surface tensions [l, 2] and 1969 for interfacial tensions [3, 4]. A body of scattered data has been accumulated in the literature. This review will evaluate, compile, and interpret these results.