gebhart/patrepeval huggingface dataset:
THE FINE STRUCTURAL LOCALIZATION OF ENDOGENOUS AND EXOGENOUS PEROXIDASE ACTIVITY IN KUPFFER CELLS OF RAT LIVER (1970)

Endogenous peroxidase activity has been demonstrated in sections of rat liver fixed briefly by glutaraldehyde perfusion and incubated in Graham and Karnovsky's medium for cytochemical demonstration of peroxidase activity (29). In 25-40% of sinusoidal cells, an electron-opaque reaction product is localized in segments of the endoplasmic reticulum, including the perinuclear cisternae, a few Golgi vesicles and saccules and in some large membrane-bounded granules. This staining is abolished after prolonged fixation or boiling of tissue sections in glutaraldehyde, and in the absence of H(2)O(2) or DAB from the incubation medium. Furthermore, the reaction is inhibited completely by sodium azide and high concentrations of H(2)O(2), and partially by KCN and aminotriazole. Among the different cells in hepatic sinusoids, the nonphagocytic "fat-storing" cells (39) are always peroxidase negative, whereas the lining cells in process of erythrophagocytosis are consistently peroxidase positive. The possible biological significance of endogenous peroxidase in Kupffer cells is discussed. In addition, the uptake of exogenous horseradish peroxidase by Kupffer cells has been investigated. The exogenous tracer protein, which in contrast to endogenous peroxidase of Kupffer cells is not inhibited by prolonged aldehyde fixation, is taken up by micropinocytosis and remains confined to the lysosomal system of Kupffer cells. The significance of these observations in respect to some recent studies suggesting localization of exogenous peroxidases in the endoplasmic reticulum of Kupffer cells and peritoneal macrophages (22, 23) is briefly discussed.
3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders (2012)

Emerging evidence suggests that the pathogenesis of depressive disorders (DDs) is associated with neuronal abnormalities in brain microtubule function, including changes in α-tubulin isoforms. Currently available antidepressant drugs may act by rescuing these alterations, but only after long-term treatment explaining their delayed therapeutic efficacy. The microtubule associated protein type-2 (MAP-2) modulates neuronal microtubule dynamics. Our hypothesis is that MAP-2 represents an innovative target for the treatment of DDs. The synthetic pregnenolone-derivative MAP4343 (3β-methoxy-pregnenolone) binds MAP-2 in vitro and increases its ability to stimulate tubulin assembly. Here, we show that MAP4343 has antidepressant efficacy in rats and advantages compared with the selective serotonin reuptake inhibitor (SSRI) fluoxetine. A single injection of MAP4343 changes the expression of α-tubulin isoforms indicative of increased microtubule dynamics in the hippocampus of naïve Sprague-Dawley rats, whereas fluoxetine had no effects. MAP4343 has positive efficacy in the rat forced swimming test (FST), the most used assay to screen potential antidepressant drugs by decreasing immobility behavior. In the rat isolation-rearing model of depression, administration of MAP4343 showed more rapid and more persistent efficacy compared with fluoxetine in recovering "depressive-like" behaviors. These effects were accompanied by modifications of α-tubulin isoforms in the hippocampus, amygdala, and prefrontal cortex. Our findings suggest the potential therapeutic use of MAP4343 for the treatment of DDs, based on a unique mechanism of action.
EXPERIMENTAL RESEARCH ON TREATMENT OF Cr(VI)-BEARING WASTEWATER BY PYRITE (2001)

A reacting system has been established for the treatment of Cr(Ⅵ) bearing wastewater by pyrite.With a view to avoiding recontamination,the ions concentation of heavy metals and total Cr(Ⅵ)+Cr(Ⅲ) in the wastewater is measured after treatment to see if the amount of Cr(Ⅵ) in it has reached the discharge standard.Meanwhile,the existence style of Cr(Ⅲ) has also been studied.Analytical results of the XPS method show that,very possibly,Cr(Ⅲ) may appear as a new phase of Cr 2S 3.It can be concluded that the new method of putifying Cr(Ⅵ) bearing wastewater possesses better economic advantages and greater superiority in environmental protection.
Adaptive motion estimation algorithm using spatial and temporal correlation (2002)

Block motion estimation using full search is computationally intensive. Previously proposed fast search algorithms limit the size of search window, the size of sequence (usually QCIF format) and search locations. These algorithms do not fit for sequences having large motion or larger picture size. In this paper, we present a new fast and efficient search algorithm for block motion estimation that produce better performance in quality than TSS and 4SS and less computational time. The proposed algorithm is based on the idea of selecting an adaptive search window per macro-block using 3 spatial macro-blocks and one temporal macro-block with the distance criterion without computational burden. The result of simulation shows not only better quality of pictures than that of TSS and 4SS, but also faster execution time. Therefore it can be good solution for the real time multimedia mobile systems.
New Protopine and Benzyltetrahydroprotoberberine Alkaloids from <i>Aristolochia constricta</i> and Their Activity on Isolated Guinea-Pig Ileum (1997)

Five new protopine-type alkaloids, 3,5-di-O-methylconstrictosine (1), 5,6-dihydro-3,5-di-O-methylconstrictosine (2), 5,6-dihydroconstrictosine (3), constrictosine (4), 3-O-methylconstrictosine (5), and a novel 8-benzylberberine-type alkaloid, (-)-8 beta-(4'-hydroxybenzyl)-2,3-dimethoxyberbin-10-ol (6) were isolated from the aerial parts of Aristolochia constricta. Their structures were elucidated by physical and spectroscopic data. The results of our pharmacological experiments indicated that MeOH extract, its partially purified fraction VI and the protopine derivatives constrictosine 1-5, significantly reduced, in a dose dependent manner, the electrical, acetylcholine, and histamine contractions of the isolated guinea-pig ileum.
Beta-glucuronidase activities of fecal isolates from healthy swine (1992)

Research has shown that various percentages of fecal Escherichia coli isolates obtained from healthy subjects may be beta-glucuronidase negative. The ability to detect beta-glucuronidase activity among fecal E. coli isolates from healthy subjects may be affected by assay conditions. A study was conducted in which agar and broth media containing 4-methylumbelliferyl-beta-D-glucuronide (MUG) were used to examine beta-glucuronidase activities of fecal isolates from healthy swine. Rectal swabs were plated on MacConkey agar plus 100 mg of MUG per liter (MAC-MUG) and incubated at 35 degrees C for 24 h. Each of 986 isolates picked from MAC-MUG was inoculated into duplicate tubes of lauryl tryptose broth plus 50 mg of MUG per liter (LT-MUG). One set of tubes was incubated at 35 degrees C and the other set of tubes was incubated at 44.5 degrees C. Gas production and hydrolysis of MUG, indicated by fluorescence when observed with UV light with a wavelength of 360 nm, were determined after incubation for 24 and 48 h. A higher percentage (P less than 0.01) of isolates was MUG positive at 44.5 degrees C than at 35 degrees C after 24 h of incubation in LT-MUG. A higher percentage (P less than 0.01) of isolates was MUG positive after 48 h than after 24 h of incubation at both 35 and 44.5 degrees C. A lower percentage of isolates (P less than 0.05) was observed to be MUG positive on MAC-MUG agar compared with their MUG reactions in LT-MUG at 35 and 44.5 degrees C. Approximately 89% of the isolates identified were beta-glucuronidase-positive E. coli. The largest proportion of MUG-positive E. coli was detected with LT-MUG at 35 degrees C after 48 h of incubation.
Effect of the eruption of El Chichon on stratospheric aerosol size and composition (1983)

Dominant effects of the El Chichon eruption on stratospheric aerosols at 19.8 to 20.7 km are: (1) vapor depositional growth of the small‐aerosol (background) mode; (2) development of a large‐particle mode by sedimentation from the highest altitudes in the cloud; (3) a change in the large‐particle mode from sulfate‐coated silicates to sulfate aerosols, some with silicate cores; (4) a 100‐fold increase in sulfate mass in the large particle mode. Terminal velocities of large silicate particles, maximum r = 2.3 µm, sampled 1 month after eruption, and calibrated with the aid of lidar data, indicate initial injection to 26 to 27 km. Smaller velocities of sulfate aerosols, median r = 0.5 µm, are compatible with major growth in 2 to 3 months at 27 to 28 km. Aerosol settling accounts for the descent of the main lidar return to 26.5 km in August and to 20 to 21 km in December. Additional growth by condensation and/or coalescence during descent is required to explain the largest aerosols, r = 0.5 to 0.9 µm. Although sedimentation is the dominant cause of bimodality, mixing of air from low and high latitudes can produce bimodal or trimodal distributions.
1Efficient RNS bases for Cryptography (2015)

Abstract — Residue Number Systems (RNS) are useful for distributing large dynamic range computations over small modular rings, which allows the speed up of computations. This feature is well known, and already used in both DSP and cryptography. In this paper we deal with implementa-tion for huge numbers like those used for ciphering as with RSA or ECC on prime finite fields. Modular multiplication is the main operation of these protocols. We find very in-teresting modular multiplication algorithms in RNS where the conversion from an RNS basis to another represents the main part of the complexity. Hence, we propose in this paper an analysis of the criteria for selecting some bases giving efficient conversions. We conclude by giving methods for constructing an efficient basis in function of the size of different parameters like the basic operators, the key of the cryptosystem, etc. Residue Number Systems (RNS) are useful for distributing large dynamic range computations over small modular rings, which allows the speed up of computations. This feature is well known, and already used in both DSP and cryptography. In this paper we deal with implementation for huge numbers like those used for ciphering as with RSA or ECC on prime finite fields. Modular multiplication is the main operation of these protocols. We find very interesting modular multiplication algorithms in RNS where the conversion from an RNS basis to another represents the main part of the complexity. Hence, we propose in this paper an analysis of the criteria for selecting some bases giving efficient conversions. We conclude by giving methods for constructing an efficient basis in function of the size of different parameters like the basic operators, the key of the cryptosystem, etc.-Index Terms — RNS, MRS, modular reduction, division by a constant, bases conversion.RNS, MRS, modular re-duction, division by a constant, bases conversion.-I.
Data Fitting Problems with Bounded Uncertainties in the Data (2001)

An analysis of a class of data fitting problems, where the data uncertainties are subject to known bounds, is given in a very general setting. It is shown how such problems can be posed in a computationally convenient form, and the connection with other more conventional data fitting problems is examined. The problems have attracted interest so far in the special case when the underlying norm is the least squares norm. Here the special structure can be exploited to computational advantage, and we include some observations which contribute to algorithmic development for this particular case. We also consider some variants of the main problems and show how these too can be posed in a form which facilitates their numerical solution.
Enhanced LTE TOA/OTDOA estimation with first arriving path detection (2013)

With increasing importance of location based services, requirements for TOA (time of arrival) and TDOA (time difference of arrival) measurements have been specified in 3GPP LTE Rel. 9 to ensure accurate TIE (user equipment) positioning. In order to meet these requirements, it is vital to accurately estimate the first signal arriving path. This is, however, not trivial, especially in multipath environments. In this work, we describe methods for LTE TOA and TDOA measurements with enhanced first arriving path detection. The conventional maximum likelihood based correlation profile is used as detection metric. After grossly determining the signal region by a moving window, three methods, namely peak detection, SNR based threshold and adaptive threshold based on noise floor and metric peak value are employed to estimate the first arriving path. Simulations results show that the proposed adaptive threshold based method is robust against channel variations and can meet all 3GPP requirements under various multipath channels.
Road shape classification for detecting and negotiating intersections (2004)

This paper presents an approach to visually classifying the high-level geometry of the road ahead of a vehicle as a section with continuous curvature parallel edges or an intersection containing right-angled legs. The default behavior of the system is snake-based tracking of parallel road edges for curvature estimation. A separate process segments the road surface from the background using color appearance characteristics, then classifies the segmented road shape in a rectified view as either a standard section or one of several intersection types ("four-way", "T", "right angle", etc.). Recognition of the proper shape class of the approaching road is a prerequisite for switching between shape templates in order to successfully track road edges as the vehicle travels through intersections.
Towards Wearable Spectroscopy Bioimpedance Applications Power Management for a Battery Driven Impedance Meter (2009)

In recent years, due to the combination of technological advances in the fields of
measurement instrumentation, communications, home-health care and textile-technology the
development of medical de ...
A hybrid learning network for shift, orientation, and scaling invariant pattern recognition (2001)

A three-layer neural network is presented as a generic approach for visual pattern recognition invariant with respect to the geometric appearance such as translation, orientation and scale of the patterns. The invariant recognition is achieved by representing the geometric variations internally in the network by nodes in the input and middle layers, which are laterally connected and trained by a hybrid algorithm combining both competitive and Hebbian learning. As the result of the hybrid learning, each pattern will be represented by a particular subset of middle-layer nodes all specialized to respond to the same pattern but with different geometric appearances. The nodes in the output layer are then trained by competitive learning to recognize the different pattern internally represented by the middle-layer nodes, independent of their location, orientation and size. The proposed algorithm is generic and robust and can be applied to various practical recognition problems. Moreover, the network is relatively simple and biologically plausible and can serve as a computational model to account for the invariant object recognition in the biological visual system.
A Fast Reparameterization Procedure. (2013)

Reparameterization, also known as range pre-serving logic synthesis, replaces a logic cone by another logic cone, which has fewer inputs while producing the same out-put combinations as the original cone. It is expected that a smaller circuit leads to a shorter verification time. This paper describes an approach to reparameterization, which is faster but not as general as the previous work. The new procedure is particularly well-suited for circuits derived by localization abstraction.
Integrated Product and Process Management for Engineering Design Applications (1996)

SUKITS is a joint project of computer scientists and mechanical engineers which is devoted to the design and implementation of an integrated infrastructure for product development. This infrastructure—the CIM Manager—provides a framework for a poster
Expatriate (2015)

Abstract Expatriates are employees who take on a temporary work assignment in a foreign country for their organizations. After defining the term expatriate, this entry chronologically describes and critically discusses the various phases of the expatriate life cycle, starting with recruitment and selection, before continuing with predeparture/on‐assignment training, expatriate success, compensation, serial expatriation, and repatriation. In addition to discussing the managerial implications of each of the phases of the expatriate life cycle, this entry also critically considers the research implications of investigating a group of employees who may have nothing in common other than the fact that they have been sent by their organizations to a country other than their own.
Disability Fingerprints: Patterns of Disability in Spinal Cord Injury and Multiple Sclerosis Differ (1999)

This study shows differing diseases indeed have unique disability fingerprints, which remain unique after controlling for disease duration and for population-specific differences in physical impairment. These findings point out the need to explain the disablement process more fully.
EARLY DAYS OF THE RADIOISOTOPE PRODUCTION PROGRAM. (1966)

Epikeratophakia provides a permanent optical correction for aphakia in children with congenital or traumatic cataracts; suturing the epikeratophakia graft onto the cornea eliminates the problems of contact lens or spectacle non-compliance in these young and generally uncooperative patients and provides tectonic support to scarred and irregular corneas. Eighteen children under the age of six years underwent epikeratophakia for the correction of aphakia after the removal of trauma-induced cataracts. Graft success rate was 88%; the average change in keratometry in the patients with successful grafts was 14.82 +/- 2.0 diopters. In the 13 patients eligible for visual acuity tabulation, preoperative acuities ranged from light perception to 20/200, and postoperative acuities ranged from hand motions to 20/30. Ten (77%) had acuities of 20/80 or better. Poor results in three patients with less than 20/200 acuities were likely the results of non-compliance with amblyopia therapy. Present work indicates that in cases of traumatic cataract, the epikeratophakia procedure facilitates amblyopia therapy and decreases the astigmatism in scarred and irregular corneas.
<sup>13</sup>C NMR spectra of 1‐pyrroline 1‐oxides, 2<i>H</i>‐pyrrole 1‐oxides and related compounds (1991)

Abstract 13 C NMR data for forty 1‐pyrroline 1‐oxides, six 2H ‐pyrrole 1‐oxides, three 2H ‐pyrroles, eight 1‐pyrrolines and four related oxaziridines are reported. Comparisons are made with respect to the five‐membered ring carbons, subdividing them as the central carbons, the nitrone carbon and the gem ‐dimethyl‐substituted carbon adjacent to nitrogen. The effects of substituents on the ring are also discussed.
Philippe le Bel, pape en son royaume (2004)

Présentation des grandes lignes d'une relecture des grandes affaires qui opposèrent le roi de France Philippe le Bel et la papauté de 1301 à 1314. Les légistes de l'entourage royal, particulièrement Guillaume de Nogaret, s'efforcèrent au cours de ces affaires de transférer à la royauté capétienne les fondements mystiques de l'absolutisme et du centralisme qui caractérisaient, depuis Innocent III, la théocratie pontificale.
Near‐surface models in Saudi Arabia (2007)

ABSTRACT A single‐layer model of the near surface throughout the Kingdom of Saudi Arabia is available. While this simple model suffices for most areas and large subsurface structures, it fails in situations where the surface topography is complex, the base of weathering is below the datum, or where the time structural closure is less than the uncertainty in the static correction. In such cases, multiple‐layered models that incorporate velocities derived from analysis of first arrivals picked from seismic shot records have proved to be successful in defining the lateral heterogeneity of the near surface. The additional velocity information obtained from this first‐arrival analysis (direct as well as refracted arrivals) vastly improves the velocity–depth model of the near surface, regardless of the topography. Static corrections computed from these detailed near‐surface velocity models have significantly enhanced subsurface image focusing, thereby reducing the uncertainty in the closure of target structures. Other non‐seismic methods have been used either to confirm qualitatively or to enhance the layer models previously mentioned. Gravity data may be particularly useful in sandy areas to confirm general structure, while geostatistical modelling of vibrator base‐plate attributes has yielded information that enhances the velocity field. In the global context, exploration targets of the oil and gas industry are seeking smaller and lower relief‐time structures. Thus, near‐surface models will need to enhance and integrate these methods, particularly in areas where the assumption of flat‐lying near‐surface layers cannot be met.
The Approaching Era of the Tumor Suppressor Genes (1987)

Genes that can inhibit the expression of the tumorigenic phenotype have been detected by the fusion of normal and malignant cells, the phenotypic reversion of in vitro transformants, the induction of terminal differentiation of malignant cell lineages, the loss of "recessive cancer genes," the discovery of regulatory sequences in the immediate vicinity of certain oncogenes, and the inhibition of tumor growth by normal cell products. Such tumor suppressor genes will probably turn out to be as, if not more, diversified as the oncogenes. Consideration of both kinds of genes may reveal common or interrelated functional properties.
Hybrid OFDM-based multi-band wireless and baseband signal transmission in PON access (2012)

A hybrid OFDM-baseband (BB) signal and three-band OFDM wireless channels using the 2.5 GHz bandwidth directly modulated laser and 10 GHz bandwidth electroabsorption modulated laser in a passive optical network (PON) is investigated. Each 16-QAM OFDM wireless and 64-QAM OFDM-BB signals can achieve 11.2 and 15 Gbit/s traffic data rates, respectively, in 20 km fibre transmissions. Moreover, the network performance has also been analysed and discussed.
Pro-apoptotic effect of matrine on A549 cells and its mechanism (2007)

AIM: To study the inhibitory effect of matrine on the proliferation of A549 lung adenocarcinoma cells and its mechanism. METHODS: MTT assay,electron microscopy, and cell cycle analysis were used to examine the apoptosis in A549 cells. Expression levels of Bcl-2, Bax and caspase-3 proteins were mea-sured with flow cytometry. RESULTS: Matrine exerted anti-proliferative activity on A549 cells in a dose-and time-dependent manner. Typical apoptotic morphological changes of A549 lung adenocarcinoma cells were observed by electron microscope. Cell cycle analysis indicated that S-phase proportion was increased, as well as S/G2 phase was apparently arrested. Bcl-2 protein expression was dramatically decreased (P0.01) whereas the expression of Bax and caspase-3 was increased in A549 cells after treated by matrine. CONCLUSION: Matrine can exert the significant growth-inhibitory effect on A549 cells and induce the cell apoptosis, which is probably related with the downregulation of Bcl-2 expression via changing the permeability of mitochondrial membrane.