gebhart/patrepeval huggingface dataset:
Self-sensing magnetic bearings using parameter estimation (1997)

A signal processing technique is presented by which the position of a rotor supported in magnetic bearings may be deduced from the bearing current waveform. The bearing currents are presumed to be developed with a two-state switching amplifier which produces a substantial high-frequency switching ripple. This ripple is demodulated using a parameter estimation technique which extracts the length of the bearing air gap while rejecting the influence of amplifier voltage and duty-cycle variation. The performance of the estimator is evaluated both by simulation and experiment. The method is demonstrated to produce a sensor with bandwidth of at least 1 kHz and acceptably low feed-through of the bearing force.
Optical pickup for high-speed writer using multibeam laser diode (2003)

We have developed an optical pick up with multi beam laser diode (LD). Multi beam LD has three emitters and individual emitter can control independently. Primary experiment for parallel recording has done and acceptable results for Power Margin, Tilt Margin, Defocus smargin and Detrack margin have measured. After than, possibility of double speed recording has confirmed by dual beam recording method.
Ionization and Fragmentation of Some Molecules by High-Energy Electrons (1962)

The mass spectra of some 10 representative organic compounds were obtained by using electrons with an energy up to 12 kev. Modifications of the ion source were made to reduce field penetration by the filament potential and emission of secondary electrons in the ion box. The mass spectra showed some small changes from 50 to 1000 ev. The changes were due to decreases in the abundance of ions of low relative intensity. These were ions which could be produced only by a succession of fragmentation processes. The mass spectra remained remarkably constant with further increase of the voltage. The significance of the results for gas phase radiolysis by α particles and β rays is briefly considered.
Nephrotic-range proteinuria and central nervous involvement in typical hemolytic uremic syndrome: a case report (2020)

We report an adult patient presenting with nephrotic-range proteinuria and central nervous system involvement at the acute phase of post-diarrheal HUS. The reversibility of the organ damages might predict a favorable outcome.
Characterization of a Recombinant <i>Neisseria Meningitides</i>α‐2,3‐Sialyltransferase and its Acceptor Specificity (1997)

The structure and specificity of the recombinant alpha-2,3-sialyltransferase from Neisseria meninigitidis are reported. This enzyme showed an unusual acceptor specificity in that it could use alpha-terminal and beta-terminal Gal residues as acceptors. In addition (beta1-->4)-linked and (beta1-->3)-linked terminal Gal served as acceptors. These properties distinguish the bacterial enzyme from the more widely investigated mammalian equivalents. The protein was expressed as a membrane-associated protein in Escherichia coli at a level of 750 U/l (approximately 250 mg/l). The protein could be extracted with buffers containing 0.2% Triton X-100 and purified to homogeneity using immobilized-metal-affinity chromatography. Electrospray-ionization mass spectrometry of peptides obtained by cleavage with cyanogen bromide and trypsin confirmed over 95% of the deduced amino acid sequence. When used for enzymatic synthesis in coupled reactions with recombinant CMP-Neu5Ac synthetase, the alpha-2,3-sialyltransferase could sialylate fluorescent derivatives of N-acetyllactosamine with N-acetylneuraminic acid, N-propionylneuraminic acid and N-glycoloylneuraminic acid.
The effect of silica coating on the resin bond to the intaglio surface of Procera AllCeram restorations. (2003)

The use of a resin composite containing an adhesive phosphate monomer either in combination with a silane coupling/bonding agent or after tribochemical silica/silane coating revealed the highest long-term shear bond strength to the intaglio surface of Procera AllCeram restorations.
Can Hepatocellular Carcinoma (HCC) Produce Unconventional Metastases? Four Cases of Extrahepatic HCC (2013)

Aims and background Extrahepatic spread of hepatocellular carcinoma (HCC) diagnosed during the clinical course of the disease is not frequent; however, with the prolonged survival of HCC patients, the incidence of extrahepatic metastases seems to be increasing. Methods and study design We present four unusual cases of extrahepatic metastasis from HCC: the first concerns a patient who underwent a liver transplantation for HCC with cirrhosis and three years later developed metastases in the lung and the left orbit; the second is that of a patient who developed an extraperitoneal pararectal metastasis; in the third case a large osteolytic lesion developed on the left iliac bone, and in the fourth case we found an isolated metastasis in the left mandible. Results and conclusions These cases offer important information related to the unusual biology of isolated metastases from HCC after successful treatment of the primary cancer.
Orthogonal parameters with censored data (1993)

Abstract Orthogonal parameters possess inferential, numerical and interpretational conveniences. Many practical models require transformation of the natural parameters to obtain orthogonal parameters. This paper explores properties, construction and interpretation of orthogonal parameters for location-scale distributions under censoring of data. Keywords: Location-scale distributionmaximum likelihood estimationparameter transformation
Ubiquilin regulates presenilin endoproteolysis and modulates γ-secretase components, Pen-2 and nicastrin (2005)

Mutations in presenilin proteins (PS1 and PS2) lead to early-onset Alzheimer's disease. PS proteins are endoproteolytically cleaved into two main fragments: the NTF (PS N-terminal fragment) and the CTF (PS C-terminal fragment). The two fragments are believed to constitute the core catalytic enzyme activity called gamma-secretase, which is responsible for cleaving beta-amyloid precursor protein to release Abeta. Thus, studying factors that modulate PS fragment levels could provide important information about gamma-secretase. Previously, we demonstrated that the protein, ubiquilin-1, interacts both in vivo and in vitro with PS and that overexpression of ubiquilin-1 or -2 leads to increased accumulation of full-length PS proteins. Using wild-type HEK-293 cells (human embryonic kidney 293 cells) and PS-inducible cells, we now show that overexpression of either ubiquilin-1 or -2 decreases the PS NTF and CTF levels. Conversely, siRNA (small interfering RNA)-mediated knockdown of ubiquilin-1 and -2 proteins increased the PS NTF and CTF levels. We considered that ubiquilin might alter PS fragment accumulation by acting as a shuttle factor escorting PS fragments to the proteasome for degradation. However, through proteasome inhibition studies, we show that this does not occur. Instead, our results suggest that ubiquilin regulates PS fragment production. We also examined whether other components of the gamma-secretase complex are affected by ubiquilin expression. Interestingly, overexpression of ubiquilin resulted in a decrease in Pen-2 and nicastrin levels, two essential components of the gamma-secretase complex. In contrast, knockdown of ubiquilin-1 and -2 protein expression by RNAi (RNA interference) increased Pen-2 and nicastrin levels. Finally, we show that inhibition of the proteasome results in decreased PS fragment production and that reversal of proteasome inhibition restores PS fragment production, suggesting that the proteasome may be involved in PS endoproteolysis. These studies implicate ubiquilin as an important factor in regulating PS biogenesis and metabolism.
Optical-code-based IP longest prefix match with variable-length optical gates (2002)

A bottleneck arises in backbone electronic Internet Protocol (IP) routers because the lookup in a routing table is performed according to the longest prefix match. To resolve this problem, a versatile optical-code- (OC-) based longest prefix match that uses variable-length optical gates for photonic IP packet routing has been developed. The developed OC-based IP routing with the longest prefix match will reduce the number of routing entries so that the matching entry can be found more quickly. Moreover, the new routing procedure will help make photonic routers more compact and cost effective.
Transplantace krvetvorných buněk (2009)

Autologni a alogenni transplantace krvetvorných buněk tvoři
důležitou soucast lecby předevsim hematologických malignit, ale
uplatňuji se i v terapii jiných onemocněni. Provedeni
transplantace vede u řady pacientů k trvalemu vyleceni, na
druhe straně předevsim alogenni transplantace s sebou nesou
riziko cetných komplikaci. Nasledujici přehledna prace obsahuje
informace o typech transplantatů, jejich odběrech a zpracovani,
dale o možnostech a způsobech vyhledavani vhodných darců
krvetvorných buněk. Dalsi casti jsou věnovany připravným
předtransplantacnim režimům a komplikacim, ktere mohou po
provedeni transplantace nastat. Posledni cast se zabýva
klinickým využitim transplantaci krvetvorných buněk a je zde
uveden přehled diagnoz, u kterých lze tuto lecebnou metodu
použit.
Exact result for nonreciprocity in one-dimensional wave transmission (2003)

For sound waves impinging on a one-dimensional medium, we show that nonlinearity can lead to nonreciprocal transmission, without dissipation or broken time reversal invariance. Placing quasi-monochromatic filters at the ends of the nonlinear medium, nonreciprocity can be obtained without the generation of higher harmonics outside the medium. Remarkably, in this configuration the nonreciprocity is found to be proportional to the net energy flow when monochromatic sources of equal strength (at the filter frequency) are simultaneously turned on at both ends. This result is conjectured to be general for one dimensional scattering. It is also shown that although simultaneous monochromatic sources lead to net energy flow, with sources of small but non-zero bandwidth there is no net energy transport, in accordance with the second law of thermodynamics.
Unremarkable networking (2012)

This paper extends the focus of current research into home networks. It represents a shift in perspective from the home network as something that is essentially understood as a technological object by the inhabitants of the home, to something that is understood by household members as a sociological object wrapped up in the organisation of their everyday lives. This shift in perspective is significant. It moves the focus of design from developing home network technologies that better support users' management of the home network and the devices that hang off it, to developing home network technologies that support household members' management of everyday life and the social activities that compose it. Through a range of ongoing ethnographic studies we elaborate this turn to the social, and a number of sensitising concerns informing the continued development of home network technologies.
Diamond Networks With Bursty Traffic: Bounds on the Minimum Energy-Per-Bit (2013)

When data traffic in a wireless network is bursty, small amounts of data sporadically become available for transmission, at times that are unknown at the receivers, and an extra amount of energy must be spent at the transmitters to overcome this lack of synchronization between the network nodes. In practice, predefined header sequences are used with the purpose of synchronizing the different network nodes. However, in networks where relays must be used for communication, the overhead required for synchronizing the entire network may be very significant. In this paper, we study the fundamental limits of energy-efficient communication in an asynchronous diamond network with two relays. We formalize the notion of relay synchronization by saying that a relay is synchronized if the conditional entropy of the arrival time of the source message given the received signals at the relay is small. We show that the minimum energy-per-bit for bursty traffic in diamond networks is achieved with a coding scheme where each relay is either synchronized or not used at all. A consequence of this result is the derivation of a lower bound to the minimum energy-per-bit for bursty communication in diamond networks. This bound allows us to show that schemes that perform the tasks of synchronization and communication separately (i.e., with synchronization signals preceding the communication block) can achieve the minimum energy-per-bit to within a constant fraction that ranges from 2 in the synchronous case to 1 in the highly asynchronous regime.
Initiation of an Acetylene-Terminated Phenyl Quinoxaline (1982)

A series of heterogeneous mixtures was made by adding various amounts of bis(triphenyl phosphine) nickel II chloride, as an initiator, to an acetylene-terminated phenylquinoxaline. The series was then evaluated using the Differential Scanning Calorimeter (DSC) and the shifts in the exothermic reaction with temperature were associated with the initiator concentrations. From these data, the initiator concentration of 1.0%, by weight, was selected for further investigation. Control samples of the polymer sans initiator were also carried through the investigation. Heats of reaction were measured for these materials in both air and nitrogen atmospheres. Specimens were then interrupted at various stages of cure at 177°C (350°F). Subsequently, these specimens were placed in the DSC and the residual exotherms were measured. The data were interpreted in terms of the extent of cure and used in conjunction with Kinetic theory to estimate the maximum amount of cure that could be expected at 177°C (350°F). The methods and results are discussed herein.
A “modified crossover technique” for vascular access management in high‐risk patients undergoing transfemoral transcatheter aortic valve implantation (2012)

Our "modified crossover technique" using the left radial artery as the diagnostic site for balloon inflation appears a helpful adjunct in managing TAVI vascular access sites.
Differential expression of two pathways of chemokine induction protect CD14- and TLR4-deficient mice from localized E. coli infections (94.16) (2010)

Abstract Sepsis, characterized by a systemic bacterial infection, is a life-threatening condition that can lead to multi-organ failure and death from septic shock. We have observed that CD14- and TLR4-deficient mice are resistant to death by sepsis from several different clinical isolates of E. coli injected intra-peritoneally. This resistance has been attributed to the 10-fold lower levels of the proinflammatory cytokines TNF and IL-6 induced in these mice. Surprisingly, however, neither TLR4- nor CD14-deficient mice were resistant to two closely related organisms that differed only in that they expressed a K1 polysaccharide capsule, even though these mice continued to express low levels of the proinflammatory cytokines. These and other observations suggest that the ability to limit bacterial dissemination may be equally or even more important than reducing the levels of these proinflammatory cytokines in preventing death from sepsis. We present evidence here, that the pathogenic role for the CD14/TLR4 pathway in severe infection, whereby it mediates the induction of proinflammatory cytokines, may be secondary to a more important insidious role whereby differential activation of local and systemic pathways of chemokine induction via CD14/TLR4-dependent and independent mechanisms generate chemokine gradients that prevent PMN transmigration from the blood to infected tissue and facilitates the dissemination of bacteria from a localized site of infection.
Dose dependent modulation of receptor dynamics and uterine growth in immature rat by estradiol: importance of an additional nuclear binding at 24 hr for long-term (72 hr) uterine growth. (1982)

Administration of a low dose of estradiol (0.25 or 2.5 microgram/animal) to immature rats caused a pulsatile receptor translocation, resulting in a single nuclear receptor peak (1-3 hr) and maintenance of the uterine growth until 24 hr. At a higher dose (10.0 microgram/rat), maintaining the circulatory estradiol levels for a longer duration, a biphasic nuclear translocation occurred. The usual profile of nuclear receptor binding until 12 hr was followed by a second phase of receptor translocation, resulting in an additional nuclear receptor peak at 24 hr. The uterus continued to grow until 72 hr, reaching five times its original wet weight. The duration of receptor interaction and the magnitude of uterine stimulation would, therefore, appear to be largely dependent upon the period of bioavailability of estradiol. However, there are additional intracellular regulatory mechanisms not fully understood as yet, which seem to modulate the cytosol-nuclear receptor dynamics, thus influencing the extent of uterine stimulation.
Growing raspberries for home use (1940)

12 pages; includes drawings. This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.
Pulmonary hemodynamics in respiratory acidosis in dogs (1963)

Pulmonary vascular resistance of intact anesthetized dogs rose during constant ventilation with 5–8% CO 2 . This rise was not due to mechanical effects of decreased pulmonary artery or left atrial pressures or to decreased cardiac output, but appeared to be due to active pulmonary vasoconstriction. The increased pulmonary vascular resistance during CO 2 breathing was eliminated by either adrenalectomy or sham operation, but not by acute hemorrhage, indicating that some mechanism other than blood loss accounted for the failure of response. This effect of operation may explain the variation in results previously reported. The mechanism is not known, but may be related to altering adrenal medullary secretions, which are known to cause pulmonary vasoconstriction. The response to CO 2 was not restored in adrenalectomized animals by administration of maintenance or extra hydrocortisone, suggesting that the failure of pulmonary vascular resistance to rise in laparotomized animals was not due to adrenocortical depletion following surgery.
Demonstration by lectin‐gold cytochemistry of transfer of glycoconjugates of oviductal origin to the zona pellucida of oocytes after ovulation in hamsters (1990)

We have previously localized an antigen of oviductal origin to the zona pellucida of superovulated hamster oocytes (Kan et al.: Journal of Histochemistry and Cytochemistry 36:1441-1447, 1988) and described the intracellular distribution of this antigen in the oviductal epithelium (Kan et al.: Biology of Reproduction 40:585-598, 1989). These results led to our hypothesis that the oviduct is a bona fide site of origin of certain components of the zona pellucida. In this report, using the high resolution lectin-gold approach with Helix pomatia lectin (HPL)-colloidal gold complex, we present cytochemical evidence to show that glycoconjugates containing terminal N-acetyl-D-galactosamine residues are absent from the zona pellucida of ovarian oocytes but are synthesized and secreted by the nonciliated secretory cells of the oviduct and later become associated with well-defined structural elements of the zona matrix of oocytes during passage through the oviduct. The nature of the HPL-binding glycoconjugates was determined by biochemical analyses. Electrophoretic and immunological experiments demonstrated that the glycoconjugates correspond to the high molecular weight polydispersed glycoprotein that we have previously described. We have designated this glycoprotein "hamster oviductin 1" (Hm OV-1). Our results further substantiate the belief that the oviduct is a source of origin of zona pellucida constituents.
Cost-effective Use of Rapid Diagnostic Techniques in the Treatment and Prevention of Viral Respiratory Infections (2005)

The most cost-effective current use of rapid respiratory virus diagnostics is through highly sensitive and specific molecular assays (mostly PCR-based) in the hospital setting or for chronically ill or immunocompromised outpatients. Specifically, this cost savings is the result of preventing hospitalization or decreasing length of hospitalization, decreasing unnecessary testing and procedures, directing specific therapy, and reducing unnecessary antibiotic use. Equally important is community surveillance by informing physicians rapidly what agents are in the community. Important ongoing issues regarding the cost-effective use of these assays include the cost of reagents or machinery, reimbursement for testing, the need for reliable commercial reagents, the need for open platforms that can respond to new "emerging" or "reemerging" agents, and the need for proficiency panels to share between laboratories. Rapid molecular diagnostic assays for the detection of respiratory viruses have moved into the mainstream of clinical testing. These assays already play important roles in select populations and clinical situations for critical patient management. In addition, there are numerous clinical scenarios where the use of these assays should have a positive cost/benefit ratio. Further work needs to be done to demonstrate this benefit to society. Further development of multiplex assays and decreasing the cost of testing will help improve the benefit of these assays to clinical care. Work is underway on large multiplex molecular assays with high sensitivity and specificity that will be able to be used in an outpatient setting both because of speed and low cost. The future holds great potential for physicians. who soon may be able to answer the age-old question, "Doc, what do I have?" with more than, "You probably have a virus."
Efficacy of two 65 % permethrin spot-on formulations against canine infestations of Ctenocephalides felis and Rhipicephalus sanguineus. (2002)

The efficacy of two formulations of a topically applied 65% permethrin spot-on for dogs (Defend EXspot Treatment for Dogs, Schering-Plough Animal Health Corp.) was evaluated against experimental infestations of the cat flea, Ctenocephalides felis, and the brown dog tick, Rhipicephalus sanguineus. Thirty dogs were randomly allocated to treatment with 65 % permethrin in diethylene glycol monomethyl ether (original formulation), 65 % permethrin in propylene glycol monomethyl ether (test formulation), or to an untreated control group. Dogs assigned to treatment with a permethrin formulation received either 1 or 2 ml of the formulation in accordance with label directions on Day 0. One hundred unfed, adult cat fleas and 50 unfed, adult ticks were placed on each dog on Days -1, 5, 12, 19, 26, 33, and 40. Live fleas and ticks were counted on each dog on Days 2, 7, 14, 21, 28, 35, and 42. Treatment of dogs with either formulation of 65 % permethrin significantly (P <.05) reduced the number of live fleas and ticks from Days 2 through 42. No statistical differences were noted between the formulations regarding efficacy against C. felis or R. sanguineus.