gebhart/patrepeval huggingface dataset:
Endocrine, paracrine and autocrine regulation of trophoblastic metalloproteinases. (2001)

Gelatinase A and B (MMP-2 and MMP-9) are secreted by cytotrophoblast (CTB); these enzymes digest the major constituents of the endometrial extracellular matrices (ECM). Direct evidence links the expression of MMPs to the metastatic phenotype of tumour cells and tissue inhibitor of metalloproteinases (TIMP) to the inhibition of metastatisation. Gelatinase B (MMP-9, and no other MMP) has been shown in vitro to mediate CTB invasion. ECM components are known to influence adhesion, spreading, migration and differentiation of cells through specific cell surface receptors called integrins. While CTB migrate from the villous into the decidua they modulate their integrin repertoire, secrete MMP-9 and acquire the capacity to digest their environment. Although CTB behave like metastatic cells, in vivo they are only transiently invasive (first trimester) and their invasion is essentially limited to the endometrium and to the proximal myometrium. This temporal and spatial regulation seems to be mediated in a paracrine way by uterine factors and in an autocrine way by trophoblastic factors. We investigated the effects of endometrial regulators such as leukaemia inhibitory factor (LIF), tumour necrosis factor (TNF), transforming growth factor beta (TGFb), interleukin-1 and 6 (IL-1, IL-6) and insulin-like growth factor binding protein-1 (IGFBP-1) as well as trophoblastic factors such as hCG and leptin. All these factors markedly influenced the secretion and/or activation of MMP-2 and MMP-9. Most cytokines influence cell behaviour by modulating phosphorylation of transcription factors. Among these we identified two oncogene products (Jun and Fos) which were activated by TNF or phorbol esters and which promoted the synthesis of MMP-9. We conclude that decidual and trophoblastic products are autocrine or paracrine regulators of trophoblastic invasion of the endometrium and that some of these products act by activating the transcription of early response genes such as transcription factors.
Conductivity Anisotropy of Polyphosphazene−Montmorillonite Composite Electrolytes (1996)

The conductivity of an ordered polyphosphazene·Na+−montmorillonite composite has been measured perpendicular (σpara) and parallel (σperp) to the montmorillonite layers, and the σpara/σperp is about 100. The temperature dependence of the conductivity is consistent with a coupling between long-range Na+ movement and high-amplitude segmental motion of the polymer. The anisotropy is attributed to greater tortuosity of the Na+ diffusion perpendicular to the montmorillonite layers.
Mitochondrial DNA polymerase-γ and human disease (2006)

The maintenance of mitochondrial DNA (mtDNA) is critically dependent upon polymerase-gamma (pol-gamma), encoded by the nuclear gene POLG. Over the last 5 years, it has become clear that mutations of POLG are a major cause of human disease. Secondary mtDNA defects characterize these disorders, with mtDNA depletion, multiple mtDNA deletions or multiple point mutations of mtDNA in clinically affected tissues. The secondary mtDNA defects cause cell and tissue-specific deficiencies of mitochondrial oxidative phosphorylation, leading to organ dysfunction and human disease. Functional genetic variants of POLG are present in up to approximately 0.5% of the general population, and pathogenic mutations have been described in most exons of the gene. Clinically, POLG mutations can present from early neonatal life to late middle age, with a spectrum of phenotypes that includes common neurological disorders such as migraine, epilepsy and Parkinsonism. Transgenic mice and biochemical studies of recombinant mutated proteins are helping to unravel mechanisms of pathogenesis, and patterns are beginning to emerge relating genotype to phenotype.
Is Anastrozole Superior to Tamoxifen as First-Line Therapy for Advanced Breast Cancer?: In Reply (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.9.2580 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11331346 Is Anastrozole Superior to Tamoxifen as First-Line Therapy for Advanced Breast Cancer?: In Reply J. M. NabholtzxJ. M. NabholtzSearch for articles by this author , J. BonneterrexJ. BonneterreSearch for articles by this author , A. BuzdarxA. BuzdarSearch for articles by this author , J. F.R. RobertsonxJ. F.R. RobertsonSearch for articles by this author , B. ThürlimannxB. ThürlimannSearch for articles by this author , M. SteinbergxM. SteinbergSearch for articles by this author , A. WebsterxA. WebsterSearch for articles by this author , M. von EulerxM. von EulerSearch for articles by this author Show More University of California at Los Angeles, Los Angeles, CACenter Oscar Lambret, Lille, FranceM.D. Anderson Cancer Center, Houston, TXCity Hospital, Nottingham, United KingdomMedizinische Klinic C Kantonsspital, St Gallen, SwitzerlandAstraZeneca, Wilmington, DEAstraZeneca, Alderly Park, Cheshire, United Kingdom https://doi.org/10.1200/JCO.2001.19.9.2580 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
Anti-arthritic Effect of Eugenol on Collagen-Induced Arthritis Experimental Model (2012)

This study was designed to test the efficacy of eugenol, a compound obtained from the essential oil of cloves (Syzygium aromaticum) in collagen-induced arthritis (CIA), a well characterized murine model of rheumatoid arthritis. Macroscopic clinical evidence of CIA manifests first as periarticular erythema and edema in the hind paws. Treatment with eugenol starting at the onset of arthritis (day 25) ameliorated these clinical signs of CIA. Furthermore, eugenol inhibited mononuclear cell infiltration into the knee joints of arthritic mice and also lowered the levels of cytokines (tumor necrosis factor (TNF)-α, interferon (IFN)-γ and tumor growth factor (TGF)-β) within the ankle joints. Eugenol treatment did not affect the in vitro cell viability as assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Therefore, eugenol ameliorates experimental arthritis and could be useful as a beneficial supplement in treating human arthritis.
Efficient bit stream switching of H.264 coded video (2005)

Stream switching among compressed video streams coded at different quality levels and bit rates is examined, and two enhanced stream switching schemes for H.264 video are proposed in this work. The flexibility of the original H.264 stream switching scheme is achieved at the cost of coding efficiency by introducing primary and secondary SP/SI pictures. In contrast, no modification is made to the original compressed streams in our enhanced schemes so that coding efficiency is maintained at switching points. When switching occurs, the two new schemes use a new picture type, called the difference picture (DIFF), in different ways to compensate the mismatch of reference frames. The difference picture can be coded efficiently, and it is easy to pick a good quantization step size to meet the quality requirement. It is shown by experimental results that the two new schemes outperform the original H.264 switching scheme in the sense that they can achieve prompt stream switching without noticeable quality degradation, and a small amount of bit rate overhead is demanded only when switching occurs.
Parastomal hernia: incidence, prevention and treatment strategies (2008)

Parastomal hernia continues to be a common and distressing problem for patients with stomas, and research investigating prevention strategies is scant. In March 2005 Thompson and Trainor reported that the introduction of a prevention programme for 1-year post-stoma surgery formation had significantly reduced the incidence of development of parastomal hernia. This was further supported by a follow-up study in 2007, strengthening the reliability and validity of the first findings by confirming a statistically significant reduction in the incidence of parastomal hernias through the introduction of a simple non-invasive prevention programme. This article reviews the current literature on incidence, prevention and treatment, together with a step-by-step guide for stoma care nurses to implement the prevention programme and/or study within their area.
Modeling Minority Carrier’s Recombination Lifetime of p-Si Solar Cell (2012)

This paper presents the qualitative analysis of the variation of effective lifetime of minority carriers in p-type Si solar cell due to different recombination mechanisms associated with it. There is a direct relation between the minority carrier lifetime and the solar cell efficiency. The higher lifetime of minority carrier results in increased conversion efficiency of silicon solar cell. As silicon wafers are endowed with different crystal defects and grain boundaries, a reduced minority carrier lifetime is observed for both bulk and surface recombination processes that occur through these defects. A detailed knowledge of the role of recombination processes on carrier lifetime will facilitate the design of high efficiency solar cell.
Central nervous system and the pathogenesis of hypertension. Sites and mechanisms. (1991)

A large body of evidence indicates that the central nervous system plays an essential role in the pathogenesis of hypertension. However, in many cases the specific brain regions involved and the mechanisms by which these regions promote hypertension are not known. In recent years, research in this and other laboratories has attempted to determine the mechanisms by which neural and humoral signals arising in response to pathological conditions (often occurring in the periphery) interact with the central nervous system to produce hypertension. In this article, we illustrate the coupling of peripheral and central factors in the pathogenesis of hypertension by examining the central actions of angiotensin II and mineralocorticoids in the expression of renal hypertension and mineralocorticoid-salt hypertension, respectively. We also review recent data from this laboratory illustrating the involvement of medullary vasomotor centers in the development of neurogenic hypertension after sinoaortic deafferentation and in the maintenance of hypertension in the spontaneously hypertensive rat.
Heat treatment of seed tubers for control of potato blackleg (Erwinia carotovora subsp. atroseptica) and other diseases (1983)

The thermal death points of Erwinia carotovora subsp. atroseptica and subsp. carotovora were determined in relation to duration of heat treatment, age of culture and culture medium. No isolates cultured in liquid media survived heating at 53°C for 5 min while those on solid media were killed by heating at 54°C for 10 min. After immersing naturally contaminated potato tubers for 10 min in water at 55°C, Erwinia could not be detected. The same treatment of naturally or artificially contaminated seed tubers gave complete absence of blackleg infection in the field and decreased the amounts of powdery scah(Spongospora subterranea) and black scurf (Rhizoctonia solani) on progeny tubers.
Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study (2017)

Our findings suggest that betahistine (48 mg/day) therapy is effective in treating vertigo in routine clinical settings. The observed effects persisted for 2 months after treatment cessation, suggesting that betahistine may facilitate lasting vestibular compensation.
A coherent dual-channel QPSK modulation for CDMA systems (2002)

For the reverse link in code division multiple access (CDMA) systems, noncoherent 64-ary orthogonal quadrature phase shift keying (QPSK) modulation has been studied intensively since it has been employed by the IS-95 CDMA system. The wideband-CDMA (W-CDMA) personal communications service (PCS) system, which is proposed to the Joint Technical Committee (JTC) by OKI Inc., employed a coherent QPSK modulation. In the W-CDMA system, imperfect estimation of the channel parameters introduces crosstalk between the I- and Q-channels, resulting in a performance degradation. A coherent dual-channel QPSK scheme which eliminates the crosstalk is proposed. Its performance is analyzed numerically for the reverse link of the CDMA system operating over Rayleigh fading channels and compared to W-CDMA QPSK modulation and noncoherent 64-ary orthogonal QPSK modulation. In addition, computer simulation is carried out by means of the COSSAP software tool.
Developing the Smart Phone Addiction Scale and its Validity and Reliability Study (2015)

The purpose of this research is to develop the smart phone addiction scale and conduct the studies of its validity and reliability. In accordance with this purpose, a literature review was performed and an item pool was generated while developing the Scale and expert view was received for face and content validity and the scale was pilot-applied to the target group. The scale was corrected in line with the pilot application and expert views, and then it was applied to the participants and the studies were performed for factorial and structure validity and reliability. The participants of the research were categorized into two separate groups for two different studies in developing the smart phone addiction scale. The first study was composed of 234 students who study at different high schools in the city center in Sakarya for the exploratory factor analysis. The second study comprised of 228 students who study at ninth grade of different high schools in the city center in Sakarya for the confirmatory factor analysis. For the factorial validity, the scale was firstly analyzed with the exploratory factor analysis and a confirmatory factor analysis was performed to confirm this structure. Convergent and discriminant validity was applied for the structure validity of the scale. As a result, a valid and reliable smart phone addiction scale was obtained.
Oxidation of Indole to Indigotin by Pseudomonas indoloxidans* (1965)

Journal Article Oxidation of Indole to Indigotin by Pseudomonas indoloxidans Get access TAIRO OSHIMA, TAIRO OSHIMA Department of Biophysics and Biochemistry, Faculty of Science, the University of TokyoHongo, Bunkyo-ku, Tokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar SADAAKI KAWAI, SADAAKI KAWAI Department of Biophysics and Biochemistry, Faculty of Science, the University of TokyoHongo, Bunkyo-ku, Tokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar FUJIO EGAMI FUJIO EGAMI Department of Biophysics and Biochemistry, Faculty of Science, the University of TokyoHongo, Bunkyo-ku, Tokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 58, Issue 3, September 1965, Pages 259–263, https://doi.org/10.1093/oxfordjournals.jbchem.a128196 Published: 01 September 1965 Article history Received: 04 May 1965 Published: 01 September 1965
Structure and function of the ear and auditory nervous system. (1982)

The transduction from sound vibrations to a nerve ending stimulus takes place in the organ of Corti. This process, resulting from fluid particle movement of a magnitude equivalent to the dimensions of the electron cloud around an atom, involves more than a simple deformation of the sensory cell. The fluid environment of these cells must be such that it provides sufficient oxygen and nutrients for the cells' survival and at the same time maintains a condition to enhance the biophysical process. The spiral capillaries beneath the tunnel of Corti furnish the metabolites for the Cortilymph surrounding the sensory cells. The capillaries of the stria vascularis provide this structure, an organ in its own right, so that it can maintain the high potassium concentration and positive potential of endolymph which are necessary for the transduction process. The stria vascularis itself and its blood supply and the sensory cells and their blood supply are all vulnerable to attack by various toxic agents, thus altering the homeostatic condition and resulting in a hearing loss.
Image content-based retrieval and automated interpretation of fluorescence microscope images via the protein subcellular location image database (2003)

We describe the Protein Subcellular Location Image Database (PSLID), which collects and structures 2-D through 5-D fluorescence microscope images, annotations, and derived features in a relational schema. It is designed so that interpretations as well as annotations can be queried. The annotations in PSLID, composed of 28 linked tables with publicly available descriptions, provide a thorough description of sample preparation and fluorescence microscope imaging. Image interpretation is achieved using Subcellular Location Features that have been shown to be capable of recognizing all major subcellular structures and of resolving patterns that cannot be distinguished by eye. Results of queries can be ranked by image typicality and statistical tests can be performed on sets of images (e.g., to determine whether a drug alters the distribution of a tagged protein). We anticipate that PSLID will serve as a common repository for microscopy images documenting the subcellular location of proteins.
Cyanogen Azide (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyanogen AzideF. D. Marsh and M. E. HermesCite this: J. Am. Chem. Soc. 1964, 86, 20, 4506–4507Publication Date (Print):October 1, 1964Publication History Published online1 May 2002Published inissue 1 October 1964https://doi.org/10.1021/ja01074a071RIGHTS & PERMISSIONSArticle Views679Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (252 KB) Get e-Alerts Get e-Alerts
Managing Data in Motion: Data Integration Best Practice Techniques and Technologies (2013)

Managing Data in Motion describes techniques that have been developed for significantly reducing the complexity of managing system interfaces and enabling scalable architectures. Author April Reeve brings over two decades of experience to present a vendor-neutral approach to moving between computing environments and systems. Readers will learn the techniques, technologies, and best practices for managing the passage of between computer systems and integrating disparate together in an enterprise environment.

The average enterprise's computing environment is comprised of hundreds to thousands computer systems that have been built, purchased, and acquired over time. The from these various systems needs to be integrated for reporting and analysis, shared for business transaction processing, and converted from one format to another when old systems are replaced and new systems are acquired.

The management of the in motion in organizations is rapidly becoming one of the biggest concerns for business and IT management. Data warehousing and conversion, real-time integration, and cloud and big data applications are just a few of the challenges facing organizations and businesses today. Managing Data in Motion tackles these and other topics in a style easily understood by business and IT managers as well as programmers and architects.



Presents a vendor-neutral overview of the different technologies and techniques for moving between computer systems including the emerging solutions for unstructured as well as structured types
Explains, in non-technical terms, the architecture and components required to perform integration 
Describes how to reduce the complexity of managing system interfaces and enable a scalable architecture that can handle the dimensions of Data

Table of Contents


Part 1: An Introduction to Data Integration 

Part 2: Batch Data Integration 

ETL 

Data Warehousing 

Data Conversion 

Batch Data Integration Architecture and Metadata 

Part 3: Real-Time Data Integration 

Best Practice Patterns 

Technologies 

Message Modeling 

XML 

Master Data Management 

Real Time Data Integration Architecture and Metadata 

Interactions with Legacy Applications 

External Interaction 

Part 4: Cloud and Big Data Integration
Transport Planning and social network analysis: An introduction (2015)

The literatures on urban sprawl (see e.g.Axhausen, 2000 for a review), or globalisation (e
Integrated quality of service for multimedia communications (2002)

The integration of distributed multimedia systems around the unifying theme of quality of service (QOS) is addressed. A set of key QOS requirements is presented and mapped onto a provisional QOS architecture (QOS-A) that has emerged from a experimental system designed and implemented at Lancaster. The scope of the discussion is limited to aspects of a QOS-A for the support of continuous media communications. Also, the focus is on asynchronous transfer mode (ATM) at the network layer rather than the full range of multiservice networks. Functions and mechanisms for QOS support are examined and placed within the evolving QOS-A.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Structure of Cuscohygrine. Synthesis of Ethyl Homohygrinate (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Cuscohygrine. Synthesis of Ethyl HomohygrinateW. E. Sohl and R. L. ShrinerCite this: J. Am. Chem. Soc. 1933, 55, 9, 3828–3833Publication Date (Print):September 1, 1933Publication History Published online1 May 2002Published inissue 1 September 1933https://pubs.acs.org/doi/10.1021/ja01336a066https://doi.org/10.1021/ja01336a066research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Display manager for a video processing system (1991)

Thesis (B.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1991.