gebhart/patrepeval huggingface dataset:
ABSTRACT: Blake Ridge Collapse Structure: Causal Relationship With The Underlying Gas Hydrate And Influence On Geochemistry And Methane Flux? (2001)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Dynamical excitation and anelastic relaxation of ferroelastic domain walls in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">LaAlO</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (2004)

The ferroelastic domain processes responsible for low-frequency anelasticity in ${\mathrm{LaAlO}}_{3}$ have been investigated using dynamical mechanical analysis in three-point bend geometry combined with in situ optical observations under dynamic stress at high temperature. Transformations in the types of collective motion of domain walls have been observed optically. For low temperatures and small forces, the anelastic response is dominated by rapid advancement/retraction of combs of ${100{}}_{\mathrm{pc}}$ needle domains. At higher temperatures, lateral translation/rotation of ${110{}}_{\mathrm{pc}}$ twins also contributes to the response. Needle tips are pinned by a broad range of potentials, such that the ratio of mobile to static needle tips increases steadily with increasing temperature. For large forces, three distinct peaks in the relaxation spectrum can be resolved. A small low-temperature peak in the mechanical loss is attributed to the rapid saturation of weakly pinned needles. The dominant intermediate-temperature loss peak is attributed to the gradual relaxation of the comb as a whole. A third high-temperature loss peak occurs at the end of the domain-freezing regime and the beginning of the saturation regime. Activation energies for domain-wall motion of 95, 85, and 86 kJ/mol were determined for samples subjected to low, intermediate, and high forces, respectively. Cole-Cole plots of the response at small forces show a linear section at intermediate frequency and a depressed semicircle at low frequency. The semicircular portion is very well described by the Cole-Cole equation with a broadening exponent \ensuremath{\mu}. Physically, this model corresponds to a Debye-like relaxation process with a distribution of activation energies (domain-sliding regime). The broadening of the relaxation peak is a function of temperature, with \ensuremath{\mu} decreasing from 0.7 at 130 \ifmmode^\circ\else\textdegree\fi{}C to 0.5 at 205 \ifmmode^\circ\else\textdegree\fi{}C. This corresponds to an increase in the full width at half maximum of the activation-energy distribution from 9 to 21 kJ/mol. Fits to the entire data set suggest a parabolic temperature dependence of \ensuremath{\mu} with maximum at \ensuremath{\sim}120 \ifmmode^\circ\else\textdegree\fi{}C. A number of physical processes are suggested to explain this phenomenon. The linear portion of the Cole-Cole plots provides evidence for a dynamic ``transition'' between the domain-sliding and thermally activated creep regimes with increasing frequency.
Cyber-Physical Modeling and Cyber-Contingency Assessment of Hierarchical Control Systems (2015)

Online closed-loop hierarchical control systems (HCSs) are widely used in power-system operation. Like typical cyber-physical systems, the contingencies on the cyber side of an HCS may lead to inappropriate control commands, which will influence the physical power system. To evaluate the degree to which these inappropriate control commands influence the power system, we propose a cyber-physical equivalent model for HCSs. In this model, the HCS cyber network is abstracted to a directed graph consisting of data nodes and directed branches, and connectivity is described by using a node-branch incidence matrix. Using this strategy, we can describe the general information flow in an HCS using mathematical equations on the basis of which quantitative evaluation can be carried out. Furthermore, by using existing operation records, several kinds of typical cyber-contingencies are also modeled on the basis of which cyber-contingency assessment (cyber-CA) can be implemented by using a model-based approach. Considering the computational efficiency, such an approach keeps only key characteristics of the information flow rather than all features of the cyber network. In the case study, a coordinated secondary-voltage control system is studied as an example. The physical impacts of various cyber-contingencies on different data transmission and processing modules are compared. The results show that the model-based method provides improved efficiency compared with conventional simulation-based methods while maintaining accuracy.
Experimental Characterization of Composite Structures Subjected to Underwater Impulsive Loadings (2011)

The use of composite materials in the construction of marine vessels and aircrafts is increasing and motivated by low weight advantages. These structures have to offer blast resistance, which is critical for a wide range of transportation applications. In this context, we present an investigation of the performance of composite monolithic and sandwich panels subjected to underwater impulsive loadings. A fluid-structure interaction experimental setup allows monitoring the real time deflection of composite panels exposed to blast loadings, by means of a shadow moiré technique. The performance of these panels is compared to solid and sandwich steel structures having a similar areal mass. Both non-destructive and destructive post mortem analysis are conducted to evaluate the extent and the type of damage induced by the dynamic event. This characterization is performed at different locations of the specimens and for different impulse intensities. The experimental results will be correlated to numerical predictions obtained from finite element analysis in a second presentation.
High-throughput analysis of drugs in biological fluids by desorption electrospray ionizationmass spectrometry coupled with thin liquid membrane extraction (2013)

Biological fluids such as urine, saliva and whole blood were analyzed for contents of drugs by a new combination of desorption electrospray ionization mass spectrometry (DESI-MS) and thin liquid membrane extraction (TLME). Analytes from the sample were extracted into a thin liquid membrane of hexadecane deposited on a porous Teflon membrane, from which they were subsequently analyzed directly by DESI. The total analysis time was 15 minutes for analysis of several samples with a potential analysis time of less than a minute per sample. Thanks to the pre-concentration and sample clean-up built into the method, methadone was detected in urine in full-scan mode with an LOD of 4 ng mL(-1), while amitriptyline, nortriptyline and pethidine showed LODs of 17 ng mL(-1). Quantification was possible for several basic drugs using one common internal standard, providing relative accuracies in the range of 10-30%. A reliability test was performed on 20 samples with methadone, amitriptyline, nortriptyline and pethidine in urine, showing that none of the samples having concentrations above the LOD were missed and no false positives were found. Diphenhydramine and one of its metabolites were detected in authentic samples of urine and saliva, and methadone was detected from a whole-blood sample spiked to a concentration of 100 ng mL(-1). The method has several advantages, such as extremely low price in consumables, the possibility of fast analysis of very crude biofluids such as whole blood and the potential for a very high sample throughput.
Biosynthesis of Octqpine (1952)

酵母醗酵液中にアルギニンを添加した場合,オクトビンが一部生成された。これはpicrateとして分離し,ベーバークロマトグラフィにより定性的に確認された。
Thermal modeling and performance analysis of a thermoacoustic refrigerator (2003)

A heat-driven thermoacoustic refrigerator has been designed and tested. A detailed thermal model of the device is presented. Energy balances within the system are discussed using external, heat exchanger, and stack control volumes in order to clarify the relationships of work and heat fluxes below and above onset. Thermal modeling is discussed as a tool for performance analysis as well as for determining system heat losses and finding input heat flows required by a thermoacoustic code. A method of using the control volume balance equations to find stack work and device efficiencies is presented. Experimental measurements are compared to DELTAE thermoacoustic modeling predictions. Modeling results show that viscous losses within the system have a significant impact on the device performance as well as on the ability of DELTAE to accurately predict performance. Modeling has led to an understanding of system performance and highlighted loss sources that are areas for improvement in a redesign.
Application de la culture d'embryons immatures a la realisation de l'hybridation interspecifique entre Cucurbita pepo et C. ecuadorensis, F1 et BC1 (1980)

National audience
Myeloid Transcription Factor C/EBPɛ Is Involved in the Positive Regulation of Lactoferrin Gene Expression in Neutrophils (1999)

Targeted mutation of the myeloid transcription factor C/EBPɛ in mice results in gram-negative septic death at 3 to 5 months of age. This study defines the underlying molecular defects in their terminal granulocytic differentiation. The mRNA for the precursor protein of the cathelin-related antimicrobial peptides was almost completely absent in the bone marrow cells of C/EBPɛ−/− mice. This finding may help explain their susceptibility to gram-negative sepsis, because both are bacteriocidal peptides with potent activity against gram-negative bacteria. Superoxide production was found to be reduced in both granulocytes and monocytes of C/EBPɛ−/− mice. While gp91 phox protein levels were normal, p47phox protein levels were considerably reduced in C/EBPɛ −/− granulocytes/monocytes, possibly limiting the assembly of the NADPH oxidase. In addition, expression of mRNA of the secondary and tertiary granule proteins, lactoferrin and gelatinase, were not detected, and levels of neutrophil collagenase mRNA were reduced in bone marrow cells of the knock-out mice. The murine lactoferrin promoter has a putative C/EBP site close to the transcription start site. C/EBPɛ bound to this site in electromobility shift assay studies and mutation of this site abrogated binding to it. A mutation in the C/EBP site reduced the activity of the promoter by 35%. Furthermore, overexpression of C/EBPɛ in U937 cells increased the activity of the wild-type lactoferrin promoter by 3-fold. In summary, our data implicate C/EBPɛ as a critical factor of host antimicrobial defense and suggests that it has a direct role as a positive regulator of expression of lactoferrin in vivo.
Inhibition of NF-κB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner (2009)

A skin-specific block in NF-kappaB signaling leads to hyperproliferation of the keratinocytes, inflammation, and spontaneous development of squamous cell carcinoma (SCC). Here we show that an inhibition of NF-kappaB signaling in keratinocytes, via the expression of the super-repressor/ degradation-resistant form of the IkappaBalpha protein (IkappaBalphaDN), interferes with the growth arrest induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA). The IkappaBalphaDN cells are able to overcome the TPA-induced cell cycle block. Although SCC development as well as hyperproliferation due to IkappaBalphaDN expression in keratinocytes is known to require TNFR1 signaling, the effect of IkappaBalphaDN on phorbol ester signaling is downstream/independent of TNFR1. These data thus identify an interaction between IkappaBalphaDN and the tumor promoter TPA in the growth regulation of keratinocytes. The proposed mechanism is also likely to be significant in the process of cancer development due to NF-kappaB inhibition.
Risk Stratification for Noncardiac Surgery (2004)

Letters6 January 2004Risk Stratification for Noncardiac SurgeryPaul A. Grayburn, MD and L. David Hillis, MDPaul A. Grayburn, MDFrom Baylor Heart and Vascular Institute, Dallas, TX 75246; and University of Texas Southwestern Medical Center, Dallas, TX 75390.Search for more papers by this author and L. David Hillis, MDFrom Baylor Heart and Vascular Institute, Dallas, TX 75246; and University of Texas Southwestern Medical Center, Dallas, TX 75390.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-1-200401060-00037-w3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:As stated in our paper, the ultimate goal of “risk stratification” is to reduce risk. Accordingly, diagnostic tests that are used to define risk should first have likelihood ratios that accurately define risk and second should sort patients into clearly defined risk groups. Unfortunately, the diagnostic tests that are currently used in preoperative risk stratification for noncardiac surgery do not accomplish these goals, and under most circumstances, fail to add to the known clinical risk profile. Moreover, decision analytic models indicate that a strategy of routine preoperative testing followed by cardiac catheterization and revascularization in patients with abnormal ...References1. Mason JJ, Owens DK, Harris RA, Cooke JP, Hlatky MA. The role of coronary angiography and coronary revascularization before noncardiac vascular surgery. JAMA. 1995;273:1919-25. [PMID: 7783301] CrossrefMedlineGoogle Scholar2. Fleisher LA, Skolnick ED, Holroyd KJ, Lehmann HP. Coronary artery revascularization before abdominal aortic aneurysm surgery: a decision analytic approach. Anesth Analg. 1994;79:661-9. [PMID: 7943772] CrossrefMedlineGoogle Scholar3. Auerbach AD, Goldman L. β-Blockers and reduction of cardiac events in noncardiac surgery: scientific review. JAMA. 2002;287:1435-44. [PMID: 11903031] MedlineGoogle Scholar4. Boersma E, Poldermans D, Bax JJ, Steyerberg EW, Thomson IR, Banga JD, et al . Predictors of cardiac events after major vascular surgery: role of clinical characteristics, dobutamine echocardiography, and β-blocker therapy. JAMA. 2001;285:1865-73. [PMID: 11308400] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Baylor Heart and Vascular Institute, Dallas, TX 75246; and University of Texas Southwestern Medical Center, Dallas, TX 75390. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 January 2004Volume 140, Issue 1Page: W-3KeywordsAlgorithmsAngiographyCatheterizationEchocardiographyLikelihood ratioMedical risk factorsRevascularizationSurgery ePublished: 6 January 2004 Issue Published: 6 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Practical Asymmetric Conjugate Alkynylation of Meldrum’s Acid-Derived Acceptors: Access to Chiral β-Alkynyl Acids (2009)

The enantioselective conjugate addition of alkynyl nucleophiles has been a long-standing challenge in synthetic chemistry. This paper describes a highly practical asymmetric conjugate alkynylation of Meldrum's acid-derived acceptors using cinchonidine (<$100/kg) as the chiral mediator. The process provides practical access to chiral beta-alkynyl acids. Noteworthy attributes of the method are its broad scope, high functional-group compatibility, and ease of scalability.
Correlated squeezed-state approach for a dissipative two-state system (1995)

We propose a correlated squeezed-state approach to study the dissipative two-state system at zero temperature. We have found that the ground state of this system can be better described by the correlated squeezed-state ansatz than those given in earlier variational treatments. In this new ground state the suppression effect of the phonon overlapping integral on the renormalized tunneling parameter is much more alleviated. Thus, the condition for the localization-delocalization transition of the two-state system is significantly modified in this correlated squeezed state, when compared with previous studies.
Surface acoustic wave gas sensor based on film conductivity changes (1986)

Abstract The first surface acoustic wave (SAW) sensor that functions via changes in conductivity of a thin surface film is reported. A lead phthalocyanine (PbPc) thin film is deposited on the acoustic propagation path of a LiNbO 3 SAW delay line, which serves as the feedback element of an oscillator circuit. Reaction with strongly oxidizing gases, in particular NO 2 , increases the conductivity of the PbPc film. Acousto-electric coupling of the traveling electric potential wave associated with the SAW to charge carriers in the PbPc film slows the acoustic wave velocity, altering the oscillation frequency of the circuit. This sensor is about 1000 times more sensitive, in terms of the number of NO 2 molecules that can be detected (10 16 molecules/cm 3 of PbPc film), than an identical SAW sensor functioning via mass loading would be. Sensitivity to a few ppm of NO 2 in N 2 has been demonstrated.
Immune evasion in malaria: altered peptide ligands of the circumsporozoite protein (1997)

T cells are central to immunity in malaria. CD4+ helper T cells favour the generation of high-affinity antibodies that are effective against blood stages and they are necessary to establish immunological memory. The intrahepatic stage of infection can be eliminated by specific CD8+ cytotoxic T cells (CTL). Cytokines secreted by CD4+ T cells may also contribute to liver stage immunity. Evolution has selected varied mechanisms in pathogens to avoid recognition by T cells. T cells recognize foreign epitopes as complexes with host major histocompatibility (MHC) molecules. Thus, a simple form of evasion is to mutate amino acid residues which allow binding to an MHC allele. Recently, more sophisticated forms of polymorphic evasion have been described. In altered peptide ligand (APL) antagonism, the concurrent presentation of particular closely related epitope variants can prevent memory T cell effector functions such as cytotoxicity, lymphokine production and proliferation. In immune interference, the effect of the concurrent presentation of such related epitope variants can go a step further and prevent the induction of memory T cells from naive precursors. The analysis of immune responses to a protein of P. falciparum, the circumsporozoite protein (CSP), indicates that the malaria parasite may utilize these evasion strategies.
Dual-polarized beamwidth-reconfigurable Fabry-P&#x00E9;rot antenna in monolithic MEMS technology (2013)

An X-band Fabry-Pérot (FP) antenna whose beamwidth can be dynamically controlled via MicroElectroMechanical Systems (MEMS) elements is presented. The MEMS elements and the partially reflective surface (PRS) are monolithically integrated for optimal performance, achieving very low loss in the PRS and thereby high antenna radiation efficiency. In addition, the antenna operates in dual-linear polarization with independent beamwidth control of each polarization. Detailed simulation and measurement results fully validate the proposed approach.
Evaluation of Interconnect-Complexity-Aware Low-Power VLSI Design Using Multiple Supply and Threshold Voltages (2008)

This paper presents a high-level synthesis approach to minimize the total power consumption in behavioral synthesis under time and area constraints. The proposed method has two stages, functional unit (FU) energy optimization and interconnect energy optimization. In the first stage, active and inactive energies of the FUs are optimized using a multiple supply and threshold voltage scheme. Genetic algorithm (GA) based simultaneous assignment of supply and threshold voltages and module selection is proposed. The proposed GA based searching method can be used in large size problems to find a near-optimal solution in a reasonable time. In the second stage, interconnects are simplified by increasing their sharing. This is done by exploiting similar data transfer patterns among FUs. The proposed method is evaluated for several benchmarks under 90nm CMOS technology. The experimental results show that more than 40% of energy savings can be achieved by our proposed method.
Total Knee Arthroplasty in a Previously Ankylosed or Arthrodesed Knee (1996)

Few reports address the reconstructive challenge of total knee arthroplasty after a surgically fused or ankylosed knee. The long term results and complications of a large series of patients who have had their ankylosed or arthrodesed knee converted to a total knee replacement were evaluated. Thirty-seven knees (35 patients, 28 female and 7 male) without any motion in the knee were retrospectively reviewed in a multicenter study after total knee arthroplasty. The mean age was 53 years, and the average length of followup was 90 months. The results at followup showed an average 7 degrees lack of extension and 62 degrees flexion. Complications included 24% short term complications and 35% major complications with a 14% infection rate. The total complication rate was 57%. A satisfactory outcome (no pain and an unlimited ambulation distance) was obtained in only 10 patients (29%). Patients with a satisfactory outcome had an average age of 45, and postoperative knee flexion of 87 degrees, significantly different from those with an unsatisfactory outcome. There was no relationship between results and the angle at which the knee was ankylosed preoperatively. This analysis indicates that although success in reconstructing a previously ankylosed or arthrodesed knee is possible, the lack of consistent adequate motion and the complication rate may suggest that the surgeon reconsider the risks and benefits of this difficult procedure.
Experimental and Theoretical Electron Density Study of Estrone (2006)

The electron density and the electrostatic potential (ESP) distributions of estrone have been determined using X-ray diffraction analysis and compared with theoretical calculations in the solid and gas phases. X-ray diffraction measurements are performed with a Rigaku Rapid rotating anode diffractometer at 20 K. The electron density in the estrone crystal has been described with the multipole model, which allowed extensive topological analysis and calculation of the ESP. From DFT calculations in the solid state a theoretical X-ray diffraction data set has been produced and treated in the same way as the experimental data. Two sets of single molecule DFT calculations were performed: (a) An electron density distribution was obtained via a single-point calculation with a large basis set at the experimental geometry and subsequently analyzed according to the quantum theory of atoms in molecules (AIM) to obtain the bond and most atomic properties, and (b) another electron density distribution was obtained with a smaller basis set, but at a geometry optimized using the same basis set for the analysis of atomic energies. An interesting locally stabilizing hydrogen-hydrogen bond path linking H(1) and H(11B) is found which represents the first characterization of such bonding in a steroid molecule. AIM delocalization indices were shown to be well correlated to the experimental electron density at the bond critical points through an exponential relationship. The aromaticity of ring A, chemical bonding, the O(1)...O(2) distance necessary for estrogenic activity, and the electrostatic potential features are also discussed.