gebhart/patrepeval huggingface dataset:
Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: evidence for the immune hypothesis of schizophrenia (2012)

Schizophrenia is a complex mental disease caused by a combination of serial alterations in genetic and environmental factors. Although the brain is usually considered as the most relevant organ in schizophrenia, accumulated evidence suggests that peripheral tissues also contribute to this disease. In particular, abnormalities of the immune system have been identified in the peripheral blood of schizophrenia patients. To screen the serum proteomic signature of schizophrenia patients, we conducted shotgun proteomic analysis on serum samples of schizophrenia patients and healthy controls. High-abundance proteins were eliminated by immunoaffinity before LC-MS/MS analysis. The multivariate statistical test partial least squares-discriminant analysis (PLS-DA) was applied to build models for screening out variable importance in the projection (VIP) and 27 proteins were identified as being responsible for discriminating between the proteomic profiles of schizophrenia patients and healthy controls. Pathway analysis based on these 27 proteins revealed that complement and coagulation cascades was the most significant pathway. ELISA-based activity analyses indicated that the alternative complement pathway was suppressed in schizophrenia patients. Ingenuity pathways analysis was used to conduct the interaction network of 27 proteins. The network exhibited common features such as, nervous system development and function, humoral immune response and inflammatory response, and highlighted some proteins with important roles in the immune system, such as hub nodes. Our findings indicate dysregulation of the alternative complement pathway in schizophrenia patients. The protein interaction network enhances the interpretation of proteomic data and provides evidence that the immune system may contribute to schizophrenia.
Classification of enteroviruses based on molecular and biological properties. (1997)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Reactivity of (C5Me5)2Sm with aryl-substituted alkenes: synthesis and structure of a bimetallic styrene complex that contains an .eta.2-arene lanthanide interaction (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactivity of (C5Me5)2Sm with aryl-substituted alkenes: synthesis and structure of a bimetallic styrene complex that contains an .eta.2-arene lanthanide interactionWilliam J. Evans, Tamara A. Ulibarri, and Joseph W. ZillerCite this: J. Am. Chem. Soc. 1990, 112, 1, 219–223Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ja00157a035https://doi.org/10.1021/ja00157a035research-articleACS PublicationsRequest reuse permissionsArticle Views447Altmetric-Citations135LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Signal light amplification by stimulated Raman scattering in an N-channel WDM optical fiber communication system (1989)

The use of forward and backward Raman amplification in an N-channel wavelength-division-multiplexing (WDM) optical-fiber communication system is analyzed. Analytical expressions for the signals, the pumps, and the amplified spontaneous scattered power (ASSP) are presented. The crosstalk among the signal channels is analyzed in terms of system parameters. It is found that the crosstalk is negligible while low pump power is used and becomes significant if high pump power is used. The signal-to-ASSP ratio can be improved by increasing pump power; however, the improvement is small when pump power is already high. A 300-km repeater spacing with more than 20-dB signal-to-ASSP ratio is calculated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Application of Internet of Things Technology in Agricultural Production (2018)

In recent years, the Internet of Things technology has developed rapidly. The main monitoring method of the Internet of Things is to realize its functions through the nodes of the sensor. The monitoring network of the Internet of Things transmits the monitoring data back to the database for further analysis through the computer and mobile phone platform. More detailed management and arrangement are also important for energy conservation and emission reduction. The continuous development of Internet of Things technology is, to a certain extent, the premise and foundation of agricultural development, and the ultimate goal and the biggest trend of China's agricultural development. This paper outlines the application scope of Internet of Things technology, studies the framework model of agricultural internet of things and its model prediction, and proposes the practical application of Internet of Things technology in agricultural production by studying the impact of Internet of Things technology on modern agriculture.
Analysis of an LMS algorithm for unbiased impulse response estimation (2003)

In this correspondence, a least mean squares (LMS)-based algorithm is devised for unbiased system identification in the presence of white input and output noise, assuming that the ratio of the noise powers is known. The proposed approach aims to minimize the mean square value of the equation-error function under a constant-norm constraint and is equivalent to minimizing a modified mean square error (MSE) function. An analysis of the algorithm shows that the estimates will converge to the true values in the mean sense. The variances of the parameter estimates are also available. Computer simulations are included to corroborate the theoretical development and to evaluate the impulse response estimation performance of the LMS algorithm under different conditions.
Buoyant density changes in the cyanobacterium Microcystis aeruginosa due to changes in the cellular carbohydrate content (1984)

The cyanobacterium Microcystis aeruginosa was grown in light-limited chemostat cultures with various light—dark rhythms providing a total periodicity length of 24 h. The buoyant density of the cells changed in parallel with the carbohydrate content. Short incubation experiments with different light intensities, and experiments with the inhibitors iodoacetic acid and arsenate, showed that the buoyant density changes were due to variations in the cellular carbohydrate content. It seems likely that the low dark-growth yield on carbohydrate, which had been stored during the light period, served to facilitate buoyancy changes.
A Meta-Analysis of Probiotic Efficacy for Gastrointestinal Diseases (2012)

Probiotics are generally beneficial in treatment and prevention of gastrointestinal diseases. Efficacy was not observed for Traveler's Diarrhea or Necrotizing Enterocolitis or for the probiotic species L. acidophilus, L. plantarum, and B. infantis. When choosing to use probiotics in the treatment or prevention of gastrointestinal disease, the type of disease and probiotic species (strain) are the most important factors to take into consideration.
Precision differential voltage–current convertor (1973)

A new differential voltage–current convertor is proposed, which achieves high linearity and is substantially temperature independent. The effects of transistor mismatches and of limited current gain are analysed. Experimental results are given which show a considerable improvement over previous circuits.
Bovine dentin as a substitute for human dentin in shear bond strength measurements. (1999)

There were no differences in shear bond strengths between human permanent dentin and bovine coronal dentin (13.3 +/- 6.1 vs. 15.2 +/- 7.6), and between each pulpal and buccal aspect. Significant differences were found between bovine root dentin and human primary dentin (17.4 +/- 8.3 vs. 7.7 +/- 5.0, P < 0.001). Significant differences were also found between bovine root dentin and human permanent dentin (17.4 +/- 8.3 vs. 13.3 +/- 6.1, P < 0.05), and bovine root and coronal dentin (17.4 +/- 8.3 vs. 15.2 +/- 7.6, P < 0.05). Furthermore, significant differences were recorded between human primary and human permanent dentin (7.7 +/- 5.0 vs. 13.3 +/- 6.1, P < 0.001) and bovine coronal dentin (7.7 +/- 5.0 vs. 15.2 +/- 7.6, P < 0.001).
LIDAR Wind Speed Measurements of Evolving Wind Fields (2012)

Light Detection and Ranging (LIDAR) systems are able to measure the speed of incoming wind before it interacts with a wind turbine rotor. These preview wind measurements can be used in feedforward control systems designed to reduce turbine loads. However, the degree to which such preview-based control techniques can reduce loads by reacting to turbulence depends on how accurately the incomingwind field can be measured. Past studies have assumed Taylor's frozen turbulence hypothesis, which implies that turbulence remains unchanged as it advects downwind at the mean wind speed. With Taylor's hypothesis applied, the only source of wind speed measurement error is distortion caused by the LIDAR. This study introduces wind evolution, characterized by the longitudinal coherence of thewind, to LIDAR measurement simulations to create a more realistic measurement model. A simple model of wind evolution is applied to a frozen wind field used in previous studies to investigate the effects of varying the intensity of wind evolution. LIDAR measurements are also evaluated with a large eddy simulation of a stable boundary layer provided by the National Center for Atmospheric Research. Simulation results show the combined effects of LIDAR errors and wind evolution for realistic turbine-mounted LIDAR measurement scenarios.
Design and control of fault-tolerant non-isolated multiphase multilevel dc–dc converters for automotive power systems (2015)

In this paper, a bidirectional, nonisolated dc-dc converter with several interleaved phases of multilevel modules for dual low-voltage automotive power systems is presented. Instead of using a two-level stage with short-circuit protection elements, a three-level module in a multiphase structure is proposed to achieve improved fault-tolerance. The dimensioning of the required flying capacitor for multilevel dc-dc converters is described. Further, benefits such as ripple reduction, automatic fault current limitation, and enhanced efficiency are achieved. Moreover, the control strategy for normal operation including the stability of the flying capacitor voltage as well as reconfiguration after semiconductor open- and short-circuit failure for ongoing degraded operation are explained.
Endophyte-host associations in forage grasses. X. Cultural studies on some species of Acremonium sect. Albo-lanosa, including a new species, A. starrii (1987)

Volume: 30
Preclinical Restenosis Models: Challenges and Successes (2006)

Coronary artery disease remains a major problem for Western societies. The advent of percutaneous interventions, including stents has brought clinical care to a new level of efficacy, yet problems remain. Restenosis following stenting in human coronary arteries appears at last to be yielding to therapeutic strategies, especially drug eluting stents. Because therapeutic percutaneous coronary intervention is widely dominated by the intracoronary stent, restenosis therapies must include the stented coronary artery. Animal models and in particular the porcine coronary model seem to represent the human coronary artery reaction to stenting. It mimics several clinical conditions including thrombosis and neointimal formation. A key question in the era of intravascular technologies is how well this and other models can predict clinical events. This paper discusses the models and their application.
Laboratory investigation on the properties of asphalt concrete containing reclaimed asphalt pavement and waste cooking oil as recycling agent (2019)

In this study different dosages of waste cooking oil (WCO), namely, 5%, 10% and 15% (by the weight of total asphalt) have been added into an asphalt concrete containing 25%, 50% and 75% of reclaimed asphalt pavement (RAP) and the effects on volumetric and Marshall properties, indirect tensile (IDT) strength, creep and fatigue behaviour have been investigated. Results show that air voids and optimum asphalt content of the mixtures decrease with the increase of WCO and RAP content, respectively. The Marshall stability, flow and IDT grow with the increase of RAP content and drop with increasing WCO dosage. The rutting resistance was found to increase with adding RAP, with lower increase for adding 50% RAP than 25% and 75%, and decrease with adding WCO, with lower decrease for adding 10% than adding 5% and 15%. Stress-controlled fatigue tests showed that the fatigue resistance of non-rejuvenated mixtures grows with increasing RAP content, and, in general, the increase of WCO dosage results in the decrease of fatigue life. According to the results of this research, inclusion of, approximately, 4%, 7% and 10% of WCO into the mixtures containing 25%, 50% and 75% of RAP, respectively, results in a mixture with almost similar properties of the control mixture.
The development of lightweight cellular structures for metal additive manufacturing (2013)

Metal Additive Manufacturing (AM) technologies in particular powder bed fusion processes such as Selective Laser Melting (SLM) and Direct Metal Laser Sintering (DMLS) are capable of producing a fully-dense metal components directly from computer-aided design (CAD) model without the need of tooling. This unique capability offered by metal AM has allowed the manufacture of inter-connected lattice structures from metallic materials for different applications including, medical implants and aerospace lightweight components. Despite the many promising design freedoms, metal AM still faces some major technical and design barriers in building complex structures with overhang geometries. Any overhang geometry which exceeds the minimum allowable build angle must be supported. The function of support structure is to prevent the newly melted layer from curling due to thermal stresses by anchoring it in place. External support structures are usually removed from the part after the build; however, internal support structures are difficult or impossible to remove.\nThese limitations are in contrast to what is perceived by designers as metal AM being able to generate all conceivable geometries. Because support structures consume expensive raw materials, use a considerable amount of laser consolidation energy, there is considerable interest in design optimisation of support structure to minimize the build time, energy, and material consumption. Similarly there is growing demand of developing more advanced and lightweight cellular structures which are self-supporting and manufacturable in wider range of cell sizes and volume fractions using metal AM.\nThe main focuses of this research is to tackle the process limitation in metal AM and promote design freedom through advanced self-supporting and low-density Triply Periodic Minimal Surface (TPMS) cellular structures. Low density uniform, and graded, cellular structures have been developed for metal AM processes. This work presents comprehensive experimental test conducted in SLM and DMLS processes using different TPMS cell topologies and materials. This research has contributed to new knowledge in understanding the manufacturability and mechanical behaviour of TPMS cellular structures with varying cell sizes, orientations and volume fractions. The new support structure method will address the saving of material (via low volume cellular structures and easy removal of powder) and saving of energy (via reduced build-time).
An IPC protocol and its hardware realization for a high-speed distributed multicomputer system (1981)

Multicomputer systems with distributed control form an architecture that simultaneously satisfies such design goals as high performance through parallel operation of VLSI processors, modular extensibility, fault tolerance, and system software simplication. The nodes of the system may be locally concentrated or spatially dispersed as a local network. Applications range from data base-oriented transactional systems to “number crunching.” The system is service-oriented; that is, it appears to the user as one computer on which parallel processing takes place in the form of cooperating processes. Cooperation is regulated by the unique interprocess communication (IPC) protocol presented in this paper. The high-level protocol is based on the computer/producer model and satisfies all requirements for such a distributed multicomputer system. It is demonstrated that the protocol lends itself toward a straightforward mechanization by dedicated hardware consisting of a cooperation handler, an address transformation and memory guard unit, and bus connection logic. These special hardware resources, assisted by a “local operating system”, form the supervisor of a node. Nodes are connected by a high-speed bus (280M bit/sec). Programming aspects as implied by the IPC protocol are also described.
Vision-based attention in maritime environments (2011)

This paper presents a saliency inspired visual attention technique for maritime scenes. The main focus is on finding regions in images which there is a high likelihood of a maritime object being present. Experimentation has shown that many regional and global features are required because no single feature can reliably detect these objects. Examples of the features used are right angle corner detectors, edge density, and colour difference. A Gaussian classifier has been used to produce an Attention Map of pixel responses. Experiments using ground truthed images show the technique is effective on a large set of images of maritime scenes and is better at detecting maritime objects than existing generic salient detectors.
When is enough...enough (2013)

Bob is 88. His wife is ensconced in an RACF with advanced dementia. He lives alone but is struggling. His kids, although supportive, work full time and are a two-hour drive away. Bob has had several falls with admissions to our local hospital in the last 12 months. He has seen a multitude of different medical teams on each admission, had numerous investigations and assessments, and has different drug regimes prescribed.
GABA Potency at GABAA Receptors Found in Synaptic and Extrasynaptic Zones (2012)

The potency of GABA is vitally important for its primary role in activating GABA(A) receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often difficult to compare across such studies given the inevitable variations in the methods used, the cell types studied, whether native or recombinant receptors are examined, and their relevance to native synaptic and extrasynaptic GABA(A) receptors. In this review, we list the most relevant isoforms of synaptic and extrasynaptic GABA(A) receptors that are thought to assemble in surface membranes of neurons in the central nervous system. Using consistent methodology in one cell type, the potencies of the endogenous neurotransmitter GABA are compared across a spectrum of GABA(A) receptors. The highest potency for GABA is measured when activating extrasynaptic-type α6 subunit-containing receptors, whereas synaptic-type α2β3γ2 and α3β3γ2 receptors exhibited the lowest potency, and other GABA(A) receptor subtypes that are found both in synaptic and extrasynaptic compartments, showed intermediate sensitivities to GABA. The relatively simple potency relationship between GABA and its target receptors is important as it serves as one of the major determinants of GABA(A) receptor activation, with consequences for the development of inhibition, either by tonic or phasic mechanisms.
Novel lymphocyte screening tube using dried monoclonal antibody reagents (2015)

We previously developed a 10-color 11-antibody combination including a viability dye, to screen T-, B-, and natural killer (NK)-cell populations in blood, bone marrow, tissue, and body fluids. Recently, Beckman Coulter has introduced a line of dried reagents that, unlike liquid reagents and cocktails, require no refrigeration, titration, or manipulation before using. We evaluated custom tubes based on our standard lymphocyte screening panel, focusing on comparative analysis, ease of use, and advantages compared with our liquid reagent set. We tested 42 samples from blood (n = 15), bone marrow (n = 17), and tissue (n = 10) with the combination CD4/CD8/KAPPA/LAMBDA/CD19/CD56/CD5/CD20/CD10/CD3/CD45 and a vital dye by both methods and compared positivity and staining intensity for each antigen. Of the 42 samples, 5 were normal samples, 3 were red cell disorders, 20 were B-cell malignancies, 5 T-cell malignancies, 4 myeloid malignancies, and the remaining 5 were other diagnoses. Dried reagents gave equivalent staining intensity results to our standard panel in a variety of sample types, with diagnoses including reactive lymphocytosis, chronic lymphocytic leukemia, and various lymphomas. Our standard panel for evaluation of mature lymphoid malignancies allows rapid assessment of any sample type while providing direct assessment of viability. The dried reagent tube reduces preanalytical work, with simple addition of sample and the viability dye to the tube, saving time, reducing potential errors, and obviating need to titrate and monitor individual antibodies. With a shelf life of at least 12 months, the reagents also offer potential savings in reagent costs by reducing wastage due to expiration or tandem breakdown in standard liquid formulation.
MeerKAT radio observations of the 2019 outburst of the X-ray transient MAXIJ 1807+132 (2019)

We carried out two MeerKAT radio observations of the X-ray transient MAXIJ 1807+132 on September 14th and 21th, respectively. These observations were initially motivated by the detection of the new outburst from MAXI/GSC on September 10th, 2019 (Atel #13097) and the detection of the source on September 12th with Arcminute Microkelvin Imager Large Array (AMI-LA)....
Moisture effects on the dielectric properties of soils (2001)

Laboratory-measured dielectric property data and related electromagnetic wave propagation parameters are reported for a broad range of soil textures. The dielectric permittivity and phase velocity are shown to be very strong functions of volumetric soil moisture. A polynomial model for predicting soil moisture from permittivity measurements at 100 MHz is presented.