gebhart/patrepeval huggingface dataset:
Laboratorní zařízení pro in-line plazmovou úpravu polypropylenových vláken přidávaných do betonu (2012)

Prototyp byl ověřen pro zavedeni výroby a využiva barierových výbojů pro plazmove upravy PP vlaken, ktere se přidavaji do betonu. Jako plazmoveho generatoru je možne použit jakýkoli typ barierových výbojů, v nasem připadě bylo použito povrchoveho barieroveho výboje nebo DCSBD. Zařizeni umožňuje plynule nastaveni expozicni doby od 1s do 60s, při nastaveni několikanasobneho průchodu PP vlakna elektrodou je možne docilit až 180 s expozice. Upravovaný material je navijen na výstupni civku a je na ni ukladan konstantni rychlosti metodou zavit vedle zavitu. Pro definovane napnuti materialu během depozice je vstupni civka brzděna pomoci brzdy s možnosti plynule regulace. Pro definovaný přitlak materialu k elektrodě je možne použit přitlacne desky nebo valecků, ktere mohou být vyrobeny z různých materialů. Zařizeni umožňuje provaděni plazmových uprav výhradně v laboratornim vzduchu. V soucasnosti je odsavani zplodin provaděno pomoci odsavaciho trychtýře umistěneho nad zařizenim.
Selective functionalization of small organic molecules using electrophilic nitrogen sources. (2002)

Selective functionalization of small organic molecules using electrophilic nitrogen-containing reagents has been a long-standing challenge in organic synthesis. The delivery of nitrogen in the corresponding reactions can occur via a nitrenoid, radical or electrophilic pathway. Nitrogen transfer processes result in the rapid synthesis of diverse and useful products, such as aziridines, aminohalides, aminoalcohols, sulfimines and amines. This review outlines advances in the field during the past two years.
Altered IP3 receptors, IP3‐dependent Ca2+ transients and Ca2+‐dependent gene expression in a Duchenne muscular dystrophy cell line (2008)

Although deregulation of calcium handling has been recognized to play a role in Duchenne muscular dystrophy (DMD), little is known about the role of calcium release in this phenomenon. Inositol 1,4,5 trisphosphate receptors (IP 3 Rs) are located in the sarcoplasmic reticulum and nucleus of skeletal muscle cells. Upon electrical stimulation (400pulses, 1ms, 45Hz), these receptors mediate slow calcium transients, involved in gene regulation. Using normal (RCMH) and dystrophic (RCDMD) human skeletal muscle cell lines, we explored the distribution of IP 3 Rs as well as IP 3 ‐dependent calcium dynamics. Mouse oligonucleotide microarrays alowed analysis of total RNA from RCMH and RCDM myotubes obtained 4h post‐stimulus. Dystrophic cells show a five‐fold over expression of type‐2 IP 3 R; type‐2 IP 3 R locates in the nucleus in RCDMD cells, while type‐1 and type‐3 IP 3 Rs appear also to locate differently. Both cell lines displayed a slow calcium transient upon electrical stimulation, the signal being much faster and larger in RCDMD cells. IP 3 ‐mediated calcium signals induced phosphorylation of extra cellular signal‐regulated kinase (ERK1/2) in normal but not in dystrophic cells. Statistical analysis of microarrays resulted in 132 and 150 differentially expressed genes in RCMH and RCDMD respectively. As IP 3 ‐dependent calcium signals appear to be the first step in regulation of gene expression, impairment of this pathway could play an important role in DMD patho‐physiology. FONDAP 15010006
Short- and long-term outcomes of HIV-infected patients admitted to the intensive care unit: impact of antiretroviral therapy and immunovirological status (2012)

In a population of HIV-infected patients admitted to ICU, short- and long-term outcomes are related to acute illness severity and immunovirological status at admission. Complementary studies are necessary to identify HIV-infected patients who benefit from HAART use in ICU according to immunovirological status and the reasons of ICU admission.
The ActiveCrowdToolkit: An Open-Source Tool for Benchmarking Active Learning Algorithms for Crowdsourcing Research (2015)

We present an open-source toolkit that allows the easy comparison of the performance of active learning methods over a series of datasets. The toolkit allows such strategies to be constructed by combining a judgement aggregation model, task selection method and worker selection method.The toolkit also provides a user interface which allows researchers to gain insight into worker performance and task classification at runtime.
Experience gained from IMS based Fixed Mobile Converged (FMC) network deployment (2009)

The present paper describes practical experience gained with IMS based fixed mobile convergence (FMC) network deployment at TDC Denmark. The paper also takes a look into the near future, showing trend in technology. This network deployment, including the FMC component, is a joint project between TDC Denmark and Ericsson. The FMC implementation offers advanced services to enterprise users. Enterprise users may have a SIP phone, a GSM phone or both. Users may have multiple public user identities under which they may be reached or under which they may establish a call. IMS is ideally suited for FMC, due to its access network independence, its multi subscriber numbering and multi device support. The manner in which FMC is realized in IMS further facilitates that evolution towards advanced access related features such as voice call continuity and Session continuity. Previous presentation at ION provided architecture for IMS multi-access. The present paper gives feedback from the field, showing how said architecture is practically deployed and operated for enterprise subscribers.
Deleya halophila, a New Species of Moderately Halophilic Bacteria (1984)

Deleya halophila sp. nov., which was isolated from hypersaline soils, is proposed. Each of 38 isolates, together with 8 reference strains, was examined in 97 phenotypic tests, and the data were analyzed by numerical taxonomy procedures. The 38 isolates formed a distinct group at a 76% similarity value, as determined by an analysis performed with the simple matching coefficient and unweighted average linkage clustering. Characteristically, the isolates were aerobic, gram-negative rods that were motile by one to eight peritrichous flagella. They grew optimally in the presence of 7.5% (wt/vol) marine salts. The distinguishing features of the new species are its salt requirement, biochemical features, and nutritional versatility. The guanine-plus-cytosine content of the deoxyribonucleic acid is 66.7 mol%. The type strain of this species is strain F5-7 (= CCM 3662).
Validation of gallium-67-citrate single-photon emission computed tomography in biopsy-confirmed residual Hodgkin's disease in the mediastinum. (1992)

In a retrospective study of a series of 30 adult patients during restaging of Hodgkin's disease after therapy, computed tomography (CT) and biopsy results were correlated with 67Ga SPECT in order to determine the value of SPECT imaging in monitoring recurrent mediastinal Hodgkin's disease. SPECT had an overall accuracy of 93% (28/30) and correctly identified active disease in 24 of 25, 96% of histopathologically proven recurrent Hodgkin's disease. Thus in this post-therapy setting, we have confirmed the high sensitivity of 67GA SPECT scans in patients selected for biopsy. Gallium-67 may prove particularly useful in detecting residual disease activity in patients in whom biopsy was positive but the interpretations of the CT scans were uncertain in regard to presence of tumors [8/30 (27%)]. In this group of patients, we found SPECT particularly helpful. A larger prospective series is under way to assess this possibility.
Polysilanes: Solution Photochemistry and Deep-UV Lithography (1989)

The mechanism of the photochemical decomposition of a variety of alkyl polysilanes in solution has been examined. At short wavelengths, silylene extrusion is a major pathway although silyl radicals are also generated. At long wavelengths, the silylene mode is shut down and chain degradation proceeds primarily by bond homolysis. The persistent silyl radicals which are produced at room temperature are not those generated by initial chain cleavage, but result instead from the loss of one alkyl group from the chain. Evidence is presented against a simple photochemical silicon-carbon bond cleavage and in support of a more complex route initiated by a 1,1-reductive chain cleavage to generate initially chain silylene derivatives followed by rearrangement. The results of a DUV lithographic study in a bilayer configuration using poly(cyclohexylmethylsilane) as an imaging and barrier layer are reported. 0.75 μm features were resolved with a commercial 1:1 projection printer utilizing a deep-UV source and compatible optics. Sub 0.5 μm images could be resolved and transferred by O2-RIE using an excimer laser projection printer operating at 248 nm. The resolution using poly(cyclohexylmethylsilane) and excimer laser exposure far exceeds the 0.8 μm limit previously reported for some polysilane copolymers.
A FURTHER DESCRIPTION OF THE PATHOLOGIC PHYSIOLOGY OF CONGENITAL MEGACOLON AND THE RESULTS OF SURGICAL TREATMENT (1958)

Follow-up results of a series of patients with congenital megacolon operated upon between the years 1947 and 1955 are presented. The operative procedure was complete removal of the rectum and lower sigmoid with replacement by more proximal colon and a sigmoido-anal anastomosis. A discussion of the problem of anal continence in normal children as well as children upon whom a "pull through" procedure has been done has been presented. This study revealed that 50% of patients who have had pull through procedures became completely continent within 1 year, 34% became continent within 5 years, and 16% have some residual difficulty with bowel control. Analysis of the reasons for imperfect anal control reveals that enterocolitis and psychologic maladjustment are two prominent features. It is concluded that the replacement of the rectum and lower sigmoid by proximal colon in congenital megacolon has proven successful as manifested by long-term follow-up study.
Superoxide Production by Respiring Membranes of<i>Escherichia Coli</i> (1991)

O2- production by homogenates and isolated membranes of E. coli has been examined. Approximately one-fourth of the O2- generated by extracts in the presence of NAD (P) H is attributable to the membranes. The autoxidizable membrane component is a member of the respiratory chain, since O2- production is NADH-specific, amplified by cyanide, and absent from membranes lacking the respiratory NADH dehydrogenase. Other respiratory substrates (succinate, 1-phosphoglycerol, D-lactate, and L-lactate) supported O2-production at efficiencies between 3 and 30 O2- released per 10,000 electrons transferred, under conditions of substrate saturation. Membranes from quinoneless mutants quantitatively retain the ability to evolve O2-, indicating that the dehydrogenases are the sites of O2- production. Relative O2- production was greater at low substrate concentrations, probably reflecting the facilitation of unpairing of electrons that may occur when enzymes with multiple redox centers are only partially reduced. Respiration rate, cell volume, rates of membraneous and cytosolic O2- production, and SOD levels were used to calculate a steady-state concentration of O2- between 10(-10) and 10(-9) M in well-fed, aerobic, SOD-proficient cells.
FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains (2006)

Morphogenesis of the lung is regulated by reciprocal signaling between epithelium and mesenchyme. In previous studies, we have shown that FGF9 signals are essential for lung mesenchyme development. Using Fgf9 loss-of-function and inducible gain-of-function mouse models, we show that lung mesenchyme can be divided into two distinct regions: the sub-mesothelial and sub-epithelial compartments, which proliferate in response to unique growth factor signals. Fibroblast growth factor (FGF) 9 signals from the mesothelium (the future pleura) to sub-mesothelial mesenchyme through both FGF receptor (FGFR) 1 and FGFR2 to induce proliferation. FGF9 also signals from the epithelium to the sub-epithelial mesenchyme to maintain SHH signaling, which regulates cell proliferation, survival and the expression of mesenchymal to epithelial signals. We further show that FGF9 represses peribronchiolar smooth muscle differentiation and stimulates vascular development in vivo. We propose a model in which FGF9 and SHH signals cooperate to regulate mesenchymal proliferation in distinct submesothelial and subepithelial regions. These data provide a molecular mechanism by which mesothelial and epithelial FGF9 directs lung development by regulating mesenchymal growth, and the pattern and expression levels of mesenchymal growth factors that signal back to the epithelium.
Sudden infant death syndrome and weather temperature (1992)

The relationship between the days on which sudden infant death syndrome (SIDS) occurred and the daily minimum temperature was examined in Auckland (1979-1984) and Christchurch (1979-1987). There was a marked winter excess of deaths in both regions. There was a significant negative correlation between the monthly mean minimum temperature and SIDS rate for both regions (r = -0.43, n = 347, P less than 0.0001). The monthly mean minimum temperature describes SIDS mortality equally as well as the three variables of daily minimum temperature, season and geographical location. There was a significant association of SIDS with minimum temperature 4 and 5 days prior to the death after adjusting for the effect of monthly mean minimum temperature. The days preceding death were on average colder than the other days, but the effect was small, especially when compared with the magnitude of the temperature differences between consecutive months.
Ciliate Pheromones: Potential Forerunners of Self-Non-Self Cell Markers (1996)

The property of one organism to produce homologous family of protein cell markers under the control of the same genetic locus for the purpose of self-nonself discimination is not unique to multicellular life forms. It already exists in single-cell eukaryotes such as ciliates in association with their mating type process which, given its potential functional correlation with similar cell recognition mechanisms of evolutionarily more recent organisms, perhaps deserves more attention than it usually receives.
Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice (2008)

There are mainly three types of propolis whose major anticancer ingredients are entirely different: (1) CAPE (caffeic acid phenethyl ester)-based propolis in Europe, Far East and New Zealand, (2) artepillin C (ARC)-based Brazilian green propolis and (3) Brazilian red propolis. It was shown previously that NF (neurofibromatosis)-associated tumors require the kinase PAK1 for their growth, and CAPE-based propolis extracts such as Bio 30 suppress completely the growth of NF tumors in vivo by blocking PAK1 signaling. Also it was demonstrated that ARC suppresses angiogenesis, suggesting the possibility that ARC also blocks oncogenic PAK1 signaling. Here it is shown for the first time that both ARC and green propolis extract (GPE) indeed block the PAK1 signaling selectively, without affecting another kinase known as AKT. Furthermore, it was confirmed that ARC as well as GPE suppress almost completely the growth of human NF tumor xenografts in mice, as does Bio 30. These results suggest that both CAPE-based and ARC-based propolis extracts are natural anti-PAK1 remedies and could be among the first effective NF therapeutics available on the market. Since more than 70% of human cancers such as breast and prostate cancers require the kinase PAK1 for their growth, it is quite possible that GPE could be potentially useful for the treatment of these cancers, as is Bio 30.
Solute transport in cartilage undergoing cyclic deformation (2007)

There are no blood vessels in cartilage to transport nutrients and growth factors to chondrocytes dispersed throughout the cartilage matrix. Insulin-like growth factor-I (IGF-I) is a large molecule with an important role in cartilage growth and metabolism, however, it first must reach the chondrocytes to exert its effect. While diffusion of IGF-I through cartilage is possible, it has been speculated that cyclic loading can enhance the rate of solute transport within cartilage. To better understand this process, here a one-dimensional axisymmetric mathematical model is developed to examine the transport of solutes through a cylindrical plug of cartilage undergoing cyclic axial deformation in the range of 10(-3) -1 Hz. This study has revealed the role of timescales in interpreting transport results in cartilage. It is shown that dynamic strains can either enhance or inhibit IGF-I transport at small timescales (< 20 min after onset of loading), depending on loading frequency. However, on longer timescales it is found that dynamic loading has negligible effect on IGF-I transport. Most importantly, in all cases examined the steady state IGF-I concentration did not exceed the fixed boundary value, in contrast to the predictions of Mauk et al. (2003).
Sustained Photoproduction of Ammonia from Dinitrogen and Water by the Nitrogen-Fixing Cyanobacterium <i>Anabaena</i> sp. Strain ATCC 33047 (1984)

Conditions have been developed that lengthen the time during which photosynthetic dinitrogen fixation by filaments of the cyanobacterium Anabaena sp. strain ATCC 33047 proceeds freely, whereas the subsequent conversion of ammonia into organic nitrogen remains blocked, with the resulting ammonia released to the outer medium. When l-methionine-dl-sulfoximine was added every 20 h, maximal rates of ammonia production (25 to 30 mumol/mg of chlorophyll per h) were maintained for about 50 h. After this time, ammonia production ceased due to a deficiency of glutamine and other nitrogenous compounds in the filaments, conditions which finally led to cell lysis. The effective ammonia production period could be further extended to about 7 days by adding a small amount of glutamine at the end of a 40-h production period or by allowing the cells to recover for 8 h in the absence of l-methionine-dl-sulfoximine after every 40-h period in the presence of the inhibitor. A more prolonged steady production of ammonia, lasting for longer than 2 weeks, was achieved by alternating treatments with the glutamine synthetase inhibitors l-methionine-dl-sulfoximine and phosphinothricin, provided that 8-h recovery periods in the absence of either compound were also alternated throughout. The biochemically manipulated cyanobacterial filaments thus represent a system that is relatively stable with time for the conversion of light energy into chemical energy, with the net generation of a valuable fuel and fertilizer through the photoreduction of dinitrogen to ammonia.
Sci-Fri AM(2): Brachy-04: Spatial Correspondence Metrics for Assessing Longitudinal Images of Evolving Tumor (2009)

In radiotherapy, accurate response assessment is necessary for determining treatment efficacy and identifying patients that would benefit from additional or alternate modes of therapy. Conventional response assessment methods rely on uni-dimensional measurements of tumor morphology and function, and are incapable of quantifying heterogeneity of response within the tumor. A voxel-to-voxel analysis of image signal to evaluate the disease state may be more sensitive to change, and would permit the assessment of the spatial distribution of tumor response to therapy. A challenge to voxel-based approaches is the uncertainty in the spatio-temporal correspondence between assessed voxels and the underlying biological tissue element that they represent. This uncertainty arises from inter-fraction motion, deformation, and evolution of pathology. These changes can result in an apparent signal intensity change that complicates the identification of signal changes due to altered tumor function. A framework for measuring the strength of voxel to voxel correspondences between serial images has been developed and was tested on MR images of glioblastoma acquired pre and post-chemoradiotherapy. Strength of correspondence was determined by characterizing each voxel with a feature vector derived from a multi-resolution local neighbourhood computation of histogram moments, image gradients and mutual information. The metric provides a measure of confidence in the spatial-temporal correspondence between assessed voxels. A minimum requirement for strength of correspondence can then be defined and used to identify a sub-population of voxels with sufficient anatomic support to inform the selection of functional image voxel pairs for signal change analysis and quantification of response.
Performance of Axial-Flow Supersonic Compressor of XJ55-FF-1 Turbojet Engine (1949)

An investigation was conducted to determine the performance characteristics of the rotor and inlet guide vanes used in the axial-flow supersonic compressor of the XJ55-FF-1 turbojet engine. Outlet stators used in the engine were omitted to facilitate study of the supersonic rotor. The extent of the deviation from design performance indicates that the design-shock configuration was not obtained. A maximum pressure ratio of 2.26 was obtained at an equivalent tip speed of 1614 feet per second and an adiabatic efficiency of 0.61. The maximum efficiency obtained was 0.79 at an equivalent tip speed of 801 feet per second and a pressure ratio of 1.29. The performance obtained was considerably below design performance. The effective aerodynamic forces encountered appeared to be large enough to cause considerable damage to the thin aluminum leading edges of the rotor blades.
The Preparation of Benzoisothiazolo[1,2‐b][1,2]isoquinolin‐11‐one‐1,1‐dioxides from Dilithiated ortho‐Toluic Acids and Lithiated Methyl 2‐(Aminosulfonyl)benzoate. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
DTLS as Subtransport protocol (2015)

The developers of user level transports will benefit from a standard
implementation of authentication and encryption. This can be achieved
using DTLS as a sub-transport. Using DTLS enables developers to
benefit from the investment in TLS, and removes the burden and the
risks of re-creating similar technology. There are several
requirements to ensure that DTLS is a suitable sub- transport: zero
RTT setup, low overhead, and DOS prevention. The IAB SEMI workshop
outlined other potential requirements: start/stop indication, and
ability to accept indications from the network. The draft presents
guidelines for meeting these requirements in a new version of DTLS.