gebhart/patrepeval huggingface dataset:
Acoustic disruption of tumor endothelium and on-demand drug delivery for cancer chemotherapy (2019)

Chemotherapy has been the most widely used treatment against cancer, however, it is limited by its systemic toxicity as well as resistance developed by tumors' physical barriers. Herein, we propose a novel acoustically-mediated treatment regime to on-demand release therapeutics and disrupt tumor structures. By programming a high intensity focused ultrasound transducer, we can locally and digitally release gemcitabine (GEM) as well as open the local blood-tumor barrier or even tumor stroma to enhance intratumor drug delivery via acoustically-oscillating bubbles and liposomes. In our experiments, we modeled tumor endothelium by culturing a monolayer of murine endothelial cells (2H11) on transwell membrane. We locally disrupted the cultured endothelium to enhance drug penetration by using perfluorocarbon liquid droplets as breaking probes and protoporphyrin IX hybridized liposomes as drug carriers. We also demonstrated an on-demand release of GEM by digitally triggering the break of drug carriers. Moreover, we validated the acoustic tumor endothelium disruption in vivo by monitoring penetration of dye (Evans blue) in solid tumors. Therefore, we present an acoustically-mediated delivery method that both releases drug on-demand locally and opens the blood-tumor barrier to enhance drug penetration. This sets the ground for further clinical cancer therapy to improve many systemic cancer treatments.
A burst-level error generation model for 2 GHz personal radio communications (1999)

The DECT (Digital Enhanced Cordless Telecommunications) technology is one of the emergent wireless technologies offering a valid mean for new multimedia and local services. A discrete channel model of the system is presented in this paper which attempts to capture the main causes of transmission impairments. For this purpose, an hybrid model based on the concept of "macrostates" and "hidden Markov chains" is used to model different system conditions. The HMM is described in detail and compared with available data. The results obtained show a good capability of the model to represent the statistical error properties of the system.
Heat-recovery steam generators: Understand the basics (1996)

Gas turbines with heat-recovery steam generators (HRSGs) can be found in virtually every chemical process industries (CPI) plant. They can be operated in either the cogeneration mode or the combined-cycle mode. In the cogeneration mode, steam produced from the HRSG is mainly used for process applications, whereas in the combined-cycle mode, power is generated via a steam turbine generator. Recent trends in HRSG design include multiple-pressure units for maximum energy recovery, the use of high-temperature superheaters or reheaters in combined-cycle plants, and auxiliary firing for efficient steam generation. In addition, furnace firing is often employed in small capacity units when the exhaust gas is raised to temperatures of 2,400--3,000 F to maximize steam generation and thus improve fuel utilization. This article highlights some of the basic facts about gas turbine HRSGs. This information can help plant engineers, consultants, and those planning cogeneration projects make important decisions about the system and performance related aspects.
X-Ray Measurement of Microstrains in Germanium Single Crystals (1959)

The high intensity of the anomalously transmitted x-ray beam depends upon the coincidence of the nodal planes of the x-ray wave field with one set of atomic planes within the crystal when the crystal is set for Laue diffraction. If there is any structural defect within the crystal which causes some of the atoms of the crystal to deviate from their normal location in perfect planes, these atoms will no longer be at the nodes of the x-ray wave field and by their absorption they will reduce the transmitted intensity. The present paper shows how this effect may be employed to measure the amount of microstrain present in nearly perfect germanium crystals. It is found that some apparently dislocation free crystals show a greater degree of crystalline imperfection than crystals with a finite dislocation count.
Fast 3D reconstruction and recognition (2008)

In this paper we discuss methods for 3D reconstruction from a single 2D image using multiple stripe line projection. The method allows 3D reconstruction in 40 milliseconds, which renders it suitable for on-line reconstruction with applications into security, manufacturing, medical engineering and entertainment industries. We start by discussing the mathematical fundamentals of 3D reconstruction and the required post-processing operations in 3D to render the models suitable for biometric applications such as noise removal, hole filling, smoothing and mesh subdivision. The incorporation of data acquired as 3D surface scans of human faces into such applications present particular challenges concerning identification and modelling of features of interest. The challenge is to accurately and consistently find predefined features in 3D such as the position of the eyes and the tip of the nose for instance. A method is presented with recognition rates up to 97% and a preliminary sensitivity analysis is carried out concerning reconstructed and subdivided models.
Vitamin D-mediated gene expression. (1992)

The steroid hormone 1,25(OH)2D3 modulates the expression of a wide variety of genes in a tissue- and developmentally specific manner. It is well established that 1,25(OH)2D3 can up- or downregulate the expression of genes involved in cell proliferation, differentiation, and mineral homeostasis. The hormone exerts its genomic effects via interactions with the vitamin D receptor or VDR, a member of the superfamily of hormone-activated nuclear receptors which can regulate eukaryotic gene expression. The ligand-bound receptor acts as a transcription factor that binds to specific DNA sequences, HREs, in target gene promoters. The DNA-binding domains of the steroid hormone receptors are highly conserved and contain two zinc-finger motifs that recognize the HREs. The spacing and orientation of the HRE half-sites, as well as the HRE sequence, are critical for proper discrimination by the various receptors. Other nuclear factors such as fos and jun can influence vitamin D-mediated gene expression. A wide range of experimental techniques has been used to increase our understanding of how 1,25(OH)2D3 and its receptor play a central role in gene expression.
Design and flow analysis of radial and mixed flow turbine volutes (2006)

ABSTRACT. Radial and mixed flow turbines which are an important component of a turbocharger consist essentially of a volute, a rotor and a diffuser. Vaneless volute turbines, which have reasonable performance and low cost, are the most used in turbochargers for automotive engines. Care has to be done in the design of the volute, whose function is to convert a part of the engine exhaust gas energy into kinetic energy and direct the flow towards the rotor inlet at an appropriate flow angle with reduced losses. Turbulent compressible flow analysis and performance prediction using the finite volume method implemented in the ANSYS-CFX software, are carried out on two different volute types. Four volute, with different cross section areas used for radial turbines, are studied and the computed results such as the computed averaged volute exit flow angles, the volute overall loss coefficients and the exit radial velocity component distributions are compared with the available experimental data. The second volute studied is the one used for a mixed flow turbine in the turbocharger test rig at Imperial College. In this part of the study, the interest is focused on the influence of the volute inlet flow conditions on its performance (efficiency, exit flow angle, etc). 1
Antibody Quality after Sequential Immunization with Related Antigens (1963)

The response to the second antigen of a sequence of two related antigens appears to consist of two qualitatively different antibody populations. Antibodies specific for the second antigen are of primary-response quality while the antibodies which cross-react with the first antigen are of secondary-response quality.
COURTLY LOVE (1967)

Journal Article COURTLY LOVE Get access Medieval Latin and the Rise of European Love-Lyric. By PETER DRONKE. Oxford ( Clarendon Press). Vol. I, 1965, 55s. Vol. II, 1966, 45s. A. V. C. SCHMIDT A. V. C. SCHMIDT Balliol CollegeOxford Search for other works by this author on: Oxford Academic Google Scholar Essays in Criticism, Volume XVII, Issue 3, July 1967, Pages 348–356, https://doi.org/10.1093/eic/XVII.3.348 Published: 01 July 1967
Fast and simple sample introduction for capillary electrophoresis microsystems (2004)

A newly designed capillary electrophoresis (CE) microchip with a simple and efficient sample introduction interface is described. The sample introduction is carried out directly on the separation channel through a sharp inlet tip placed in the sample vial, without an injection cross, complex microchannel layouts or hardware modification. Alternate placement of the inlet tip in vials containing the sample and buffer solutions permits a volume defined electrokinetic sample introduction. Such fast and simple sample introduction leads to highly reproducible signals with no observable carry over between different analyte concentrations. The performance of the system was demonstrated in flow-injection and CE measurements of nitroaromatic explosives and for on-chip enzymatic assays of glucose in the presence of ascorbic acid. Employing an 8 cm long separation channel and a separation voltage of 4000 V it offers high-throughput flow-injection assays of 100 samples h(-1) with a relative standard deviation of 3.7% for TNT (n= 100). Factors influencing the analytical performance of the new microchip have been characterized and optimized. Such ability to continuously introduce discrete samples into micrometer channels indicates great promise for high-speed microchip analysis.
Application of surface‐enhanced Raman scattering (SERS) for the identification of anthraquinone dyes used in works of art (2005)

Abstract Surface‐enhanced Raman scattering (SERS) was investigated for applications in the analysis of anthraquinone dyes used in works of art. Two SERS procedures were developed and evaluated with three frequently used anthraquinone dyes, alizarin, carminic acid and lac dye. The first procedure involves coating a layer of silver nanoparticles directly on pieces of filter paper stained with the dyes of interest by thermal evaporation to induce SERS effect. In the second procedure, a SERS‐active Ag‐Al 2 O 3 substrate was prepared by spin‐coating an alumina‐nanoparticle layer onto a glass slide to provide the nanostructure of the substrate, followed by thermally evaporating a layer of silver nanoparticles on top of the alumina layer. Aliquots of dye solutions were delivered onto this substrate to be analyzed. Intense SERS spectra characteristic of alizarin, carminic acid and lac dye were obtained using both SERS procedures. The effects of two parameters, the concentration of the alumina suspension and the thickness of the silver nanoparticle layer on the performance of the Ag‐Al 2 O 3 substrate were examined with alizarin as the model compound. Comparative studies were conducted between the Ag‐Al 2 O 3 substrate and the SERS substrate prepared using Tollens reaction. The Ag‐Al 2 O 3 substrate was shown to offer larger enhancement and improved reproducibility than the Tollens substrates. Finally, the potential applicability of the Ag‐Al 2 O 3 substrate for the analysis of real artifact objects was illustrated by the identification of alizarin extracted from a small piece of textile dyed using traditional methods and materials. The limit of detection for alizarin was estimated to be 7 × 10 −15 g from tests performed on solutions of known concentration. Copyright © 2005 John Wiley & Sons, Ltd.
Wavelength domain optical network techniques (1990)

Optical network technology will soon allow wavelength-multiplexed optical channels to be carried to multiple terminals, giving rise to new broadband network architectures and protocols. Two stages of evolution are anticipated, with transmission-only structures appearing first and networks with optical switching appearing later. Some basic transmission considerations relating to system operation over wide optical bandwidths for both local and longer distance networks are reviewed, and the present status of experimental optical networks and the components they use are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A New Simple Synthesis of Aryl-Substituted 1,4-Diketones (1996)

1,4-Diketones have been prepared by aldol condensation of methyl ketones with α-bromo ketones in the presence of tert-butoxymagnesium or diethylamido magnesium bromide and subsequent rearrangement of the formed 4-bromo-3-hydroxy ketones under the action of triethylamine.
Customizing Kernel Functions for SVM-Based Hyperspectral Image Classification (2008)

Previous research applying kernel methods such as support vector machines (SVMs) to hyperspectral image classification has achieved performance competitive with the best available algorithms. However, few efforts have been made to extend SVMs to cover the specific requirements of hyperspectral image classification, for example, by building tailor-made kernels. Observation of real-life spectral imagery from the AVIRIS hyperspectral sensor shows that the useful information for classification is not equally distributed across bands, which provides potential to enhance the SVM's performance through exploring different kernel functions. Spectrally weighted kernels are, therefore, proposed, and a set of particular weights is chosen by either optimizing an estimate of generalization error or evaluating each band's utility level. To assess the effectiveness of the proposed method, experiments are carried out on the publicly available 92AV3C dataset collected from the 220-dimensional AVIRIS hyperspectral sensor. Results indicate that the method is generally effective in improving performance: spectral weighting based on learning weights by gradient descent is found to be slightly better than an alternative method based on estimating "relevance" between band information and ground truth.
Subjective, psychomotor, and physiological effects of cumulative doses of opioid mu agonists in healthy volunteers. (1999)

The subjective, psychomotor, and physiological effects of three opioid mu-receptor agonists were studied in healthy volunteers using a cumulative-dosing procedure. Sixteen volunteers with no history of drug abuse received i.v. injections of saline (SAL), morphine (MOR), hydromorphone (HM), or meperidine (MEP) in a randomized double-blind crossover design. Subjects received 1 injection/h for the first 4 h, and a 3-h recovery period followed. SAL was injected first during each session, then SAL or increasing doses of each drug were administered every hour for the next 3 h. The absolute doses per injection were MOR: 2.5, 5, and 10 mg/70 kg; HM: 0.33, 0.65, and 1.3 mg/70 kg; and MEP: 17.5, 35, and 70 mg/70 kg. These injections resulted in cumulative doses of MOR: 2.5, 7.5, and 17.5; HM: 0.33, 0.98, and 2.28; and MEP: 17.5, 52.5, and 122.5 mg/70 kg. Subjects completed mood forms and psychomotor tests, and physiological measures were recorded at various times after each injection and during recovery. MEP tended to produce the most intense effects immediately after drug injection, which dissipated rapidly. MOR produced the mildest effects but was associated with unpleasant side effects during recovery and after the session. HM's effects were stronger than MOR's, and the recovery from HM was slower than with MEP. None of the opioids produced consistent effects that are typically associated with abuse liability. Orderly dose-response functions suggested that our cumulative-dosing procedure is an efficient way of determining dose-response functions for multiple opioids within the same subjects within the same study.
Radiopharmaceuticals for Assessment of Multidrug Resistance P-Glycoprotein-Mediated Drug Transport Activity (2004)

Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to successful chemotherapy in cancer patients. Thus, noninvasive interrogation of Pgp-mediated transport activity in vivo would be beneficial in guiding therapeutic choices. Both small organic medicinals as well as metal complexes characterized as transport substrates for Pgp are amenable to incorporation of PET or SPECT radionuclides and may enable noninvasive imaging of Pgp in cancer patients. Toward this objective, clinically approved agents, exemplified by (99m)Tc-Sestamibi and (99m)Tetrofosmin, have already shown promise for the functional evaluation of Pgp-mediated transport activity in human tumors in vivo. In addition, selected agents from an upcoming class of substituted Schiff-base gallium(III) complexes containing an N(4)O(2) donor core in their organic scaffold and capable of generating both SPECT and PET radiopharmaceuticals have also been shown to be promising for noninvasive assessment of Pgp activity in vitro and in vivo.
Microsoft Office Access 2003 in a Snap (2004)

Microsoft Access is a database development and maintenance program, but it can be confusing when trying to learn how to complete the tasks required to create an application. Microsoft Access 2003 In a Snap can quickly show you how to complete a specific task in an easy-to-follow format complete with illustrated steps. Sections of the book are organized into task categories such as Table Creation, Queries and Form Design. Intended to keep you focused and on-target, this book does not spend time explaining database architecture or application design. If you are the casual Access user or if you use it in your day-to-day work life, this book is a great reference tool!
Very Long-Term Prognosis of Patients with Malignant Uveal Melanoma (2003)

Metastatic uveal melanoma was the leading single cause of death throughout the study. Cumulative incidences provide a sound basis for patient counseling and design of trials.
The consequences of the chemotherapy of Hodgkin's disease: The 10th David A. Karnofsky memorial lecture (1981)

The most important consequence of using chemotherapy for Hodgkin's disease is its cure. Results of the MOPP program, developed at the National Cancer Institute in 1964, indicate that the majority of the 80% of patients who attain complete remission, who are at risk for ten years, have remained disease-free. The presence of symptoms and the histologic subtype, nodular sclerosis, has had important negative influences on prognosis. Review of three long-term adverse consequences of chemotherapy revealed sterility to be the most significant effect of drug treatment in this young population. Adverse effects of the immunosuppressive drugs in MOPP proved to be minimal. The carcinogenic effect of MOPP when used alone was surprisingly small, but increased significantly when combined with irradiation. National mortality from Hodgkin's disease has decreased abruptly since the introduction of effective chemotherapy for Hodgkin's disease in 1970.
[Can an extremely elevated radiosensitivity in patients be recognized by the in-vitro testing of lymphocytes?]. (1995)

Patients with increased clinical radiosensitivity exhibited increased chromosomal damage in lymphocytes in vitro measured with chromosome painting with a FISH-technique. This technique may be useful to detect patients with severely enhanced radiosensitivity. The results suggest that if radiosensitivity is abnormally elevated this may be present and detectable in different organs.
Dynamic Wide-Area Congestion and Incident Monitoring Using Probe Data (2010)

Traffic congestion and overall performance monitoring of roadways continues to be a major initiative of departments of transportation and planning boards nationwide. Information from traffic monitoring programs has direct relevance to both analysts and the general public. Traditional data analysis tools and methods in this area fail to connect congestion data with incident and event data and thus make the task of determining the causes of congestion difficult in many cases. As more traffic data are collected, the need for tools that can facilitate effective visualization of this data, both archived and real time, is becoming increasingly apparent. The proposed congestion and incident scanner tool is a web-based application that affords dynamic and interactive analysis of traffic congestion conditions. The tool provides an intuitive, minimalistic interface for generating congestion performance visualizations for specific date ranges and locations. These visualizations improve on existing tools by allowing users to interact with and manipulate the visualizations to better highlight specific areas of interest. The integration of incident and traffic event data with visualization allows users to easily correlate congestion abnormalities with possible causes as well as evaluate the full effects of events, such as roadwork and major incidents, on traffic conditions.
Traumatic and Iatrogenic Neurological Complications After Supracondylar Humerus Fractures in Children (1995)

A retrospective review of 162 displaced supracondylar fractures in children at Los Angeles County Harbor-UCLA Medical Center from 1975-1981 revealed 23 neural injuries. These injuries occurred in 19 patients whose ages ranged from 5-11 years of age. There were 12 radial, six ulnar, and five median neuropathies detected. Four of the ulnar nerve injuries and one radial nerve injury were iatrogenic, resulting from both percutaneous pinning and open reduction and internal fixation. All of the deficits resolved spontaneously within a range of 2-6 months. The average time to resolution for traumatic injuries was 2.3 months. Fifty-eight percent of these injuries were found to be associated with a Holmberg type III fracture pattern and 42% with a type IV supracondylar fracture.
Multi Scale modeling and intricate study of MEMS based elements in RFID systems (2009)

In this paper we have implemented some of the complex modeling aspects such as multi scale modeling, Matlab, sugar based modeling and have shown the complexities involved in the device modeling of nano RFID systems taking example of MEMS models. We have shown the modeling and simulation and demonstrated some novel ideas and library development for nano RFID and its extension for MEMS devices. Reliability and packaging still remains one the major hindrances in practical implementation of nano RFID based devices and multi scale analysis also can be used in that area. Therefore to work on it by modeling and simulation will play a very important role. Thus incorporating this we can design a nano-RFID which can be used in areas like human implantation and complex banking applications. We have proposed modeling of RFID using the concept of multi scale modeling to accurately predict its properties for MEMS specific applications. Also we give the modeling of MEMS devices that are proposed recently that can see possible application in RFID. RF MEMS has been matured and its devices are being successfully commercialized but taking it to limits of nano domains and integration with singly chip RFID needs a practical modeling approach which is being proposed. We have modeled 2 MEMS based transponder and shown the distribution for multiscale modeling for nano RFID.