gebhart/patrepeval huggingface dataset:
Involvement of the L‐arginine‐nitric oxide pathway in hyperglycaemia‐induced coronary artery dysfunction of isolated guinea pig hearts (1996)

The effects of hyperglycaemia and L-arginine on flow-induced reduction of coronary artery resistance were investigated in isolated guinea pig hearts. In the presence of indomethacin, hyperglycaemia caused an increase in flow-induced vasodilatation (P < 0.05). Hyperosmotic controls failed to mimic this effect. Addition of L-arginine strongly enhanced this effect. Addition of D-arginine failed to mimic the effects of L-arginine. The effect of L-arginine was abolished by co-administration of NG-nitro-L-arginine. In the absence of indomethacin and L-arginine, the effect of hyperglycaemia was blunted, suggesting the formation of vasoconstrictive prostanoids. Addition of L-arginine again resulted in a significant increase in flow-induced vasodilatation. In conclusion our results suggest that increased flow-induced vasodilatation under hyperglycaemic conditions depends on an adequate supply of L-arginine to maintain sufficient formation of nitric oxide.
The Chemistry of the Benzyl Pyridines. IV. p-(α-and β-Dimethylaminoethyl)-2-benzylpyridines and p-(β-Dimethylaminoethyl)-diphenylmethane (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of the Benzyl Pyridines. IV. p-(α-and β-Dimethylaminoethyl)-2-benzylpyridines and p-(β-Dimethylaminoethyl)-diphenylmethaneFrank J. Villani, Mary S. King, Joseph Lang, and Domenick PapaCite this: J. Am. Chem. Soc. 1954, 76, 22, 5623–5625Publication Date (Print):November 1, 1954Publication History Published online1 May 2002Published inissue 1 November 1954https://pubs.acs.org/doi/10.1021/ja01651a008https://doi.org/10.1021/ja01651a008research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Highly Practical Route to 7-Hydroxy-1,3-dihydro-2<i>H</i>-1,4-benzodiazepin-2-one from<i>p</i>-Anisidine (1999)

Abstract The title compound was accessed via a Friedel-Crafts reaction on anisidine, followed by cyclization, N-methylation and O-demethylation. NO column chromatography was required in the process.
A parametric study of interband absorption in GaAs–Al<i>x</i>Ga1−<i>x</i>As quantum wells (1985)

Calculations of the optical transitions in GaAs–AlxGa1−xAs heterostructures are undertaken, with an eight-band k ⋅ p method. The sensitivity of the resulting spectrum to structural, as well as to material, parameters is studied. For a rectangular quantum well, we find that the available data do not allow a unique determination of the conduction band offset Qe. By accounting for experimental uncertainties, we find that any value in the range 0.5–0.9 is compatible. For parabolic wells, however, we can narrow this range to 0.5–0.65.
Studies of the relationships between <i>Schistosoma nasale</i> and <i>S. spindale</i> and their snail host <i>Indoplanorbis exustus</i> (1991)

Infectivity and cercarial production of Indoplanorbis exustus related to variation of miracidial dose (1, 4, 10 or 20) with Schistosoma nasale and S. spindale from Sri Lanka were studied. The intermediate host-parasite relationships of the two schistosome species showed marked differences under the conditions of observation recorded in this study. Prepatent death rates (PDR) were on average higher for S. spindale (30%) than for S. nasale (10%). The size of the miracidial dose to which snails had been exposed had no effect on PDR. The infection rates (IR) were on average higher for S. nasale (41%) compared with S. spindale (27%). Highest IR occurred after exposure to 4 miracidia in S. nasale infections (79%) and after exposure to 10 miracidia in S. spindale infections (60%). The highest daily average cercarial production per snail was recorded for S. nasale at a level of 4 miracidia (1311), and for S. spindale at a level of 10 miracidia (1615). At low level (1 or 4 miracidia) of exposure, I. exustus showed a better compatibility with S. nasale than with S. spindale. An opposite tendency was observed at higher levels (10 or 20 miracidia) of exposure. Unsuccessful infections of Lymnaea luteola with either S. nasale or S. spindale indicate that this species is not involved in transmission.
Clinical applications of ambulatory blood pressure monitoring: the white coat syndrome. (1991)

The estimation of an individual's true blood pressure by conventional clinical measurement is subject to a number of errors, stemming partly from the inherent variability of blood pressure, and also from the white coat syndrome, which is an elevation of blood pressure limited to the clinic setting. This may occur in about 20% of patients with mild hypertension, and is hypothesized to be a learned or conditioned response. Ambulatory monitoring may help to identify such patients. Other potential clinical applications of the technique include evaluation of patients with resistant hypertension, with excessively labile blood pressure, or with autonomic insufficiency, which may be characterized not only by hypotensive episodes, but also by hypertensive episodes during the night. An unresolved question is the definition of the upper limit of normal ambulatory pressure, which is required before ambulatory monitoring finds wide clinical acceptance.
Experimental basics for femtosecond electron diffraction studies (2007)

This paper provides a practical introduction to the current practice of femtosecond electron diffraction. We emphasize a general implementation suitable for a wide class of photoactive samples, including nonreversible samples. High density femtosecond electron pulses are required and the consequences for diffractometer design and sample preparation and handling are discussed. Finally, the real space structural analysis of strongly-driven melting in metals possible with our implementation is outlined.
Effects of Carbamazepine on Serum Electrolytes (1983)

Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland
Set-up of an Experimental Bench for Islanding Detection Methods Evaluation (2005)

International audience
Peripheral Nerve Field Stimulation for Chronic Back Pain: Therapy Outcome Predictive Factors (2020)

While these analyses are exploratory and restricted to a limited sample size, they suggest variables that may play a role in predicting a therapeutic response. These results, however, are informative only and should be cautiously interpreted. Future research to validate the variables in a clinical study is needed.
Continent Urinary Diversion: The Children's Hospital Experience (1997)

Many options exist for reconstructing complex anomalies. Choices must be individualized based on patient anatomy. The dry state may be achieved in most cases without resorting to a bag on the abdomen.
Growth of layered LiNi0.5Mn0.5O2 thin films by pulsed laser deposition for application in microbatteries (2008)

Li Ni 0.5 Mn 0.5 O 2 films were prepared by pulsed laser deposition on stainless steel (SS) and Au substrates. The substrate was found to play an important role in determining the growth of films. Although similar x-ray diffraction spectra were observed for both types of substrates, Raman spectra exhibited different features. The charge-discharge behavior of the film on the SS substrate indicates a spinel structure while the charge-discharge behavior of the film on the Au substrate indicates a layered structure. The secondary ion mass spectrometry depth-profiling results indicate interdiffusion between the film and the substrate, which inhibits the formation of pure layered LiNi0.5Mn0.5O2 phase.
Knowledge acquisition by listeners in a source learning task using physical models (2000)

Two experiments examined listeners’ ability to learn about the acoustic properties of physical models by varying the amount of structured information listeners received about the models. In experiment 1, 60 listeners participated in a repeated learning-testing paradigm, using a graphical interface to permit listeners to manipulate three acoustic properties for each of eight simulated percussive instruments. Information about the properties of the instruments varied across six conditions, ranging from highly structured (e.g., pictures of instruments, description of physical properties, sliders grouped by instrument with properties labeled) to weakly structured (e.g., unlabeled sliders arranged randomly without reference to instruments). Performance on discrimination and memory tasks suggests that learning can occur even with weakly structured acoustic information. To determine whether learning can occur even when acoustic information is obtained ‘‘passively,’’ 30 listeners in experiment 2 were yoked to listeners in three conditions of experiment 1. These former listeners heard sounds produced by the manipulations of listeners in experiment 1, but were unaware of the nature of the information in the physical model interface. Both experiments suggest that mechanisms associated with acquiring knowledge about acoustic properties may be largely automatic.
ELEVATED SERUM LEVELS OF EPITHELIAL CELL APOPTOSIS-SPECIFIC CYTOKERATIN 18 NEOEPITOPE M30 IN CRITICALLY ILL PATIENTS (2004)

Apoptosis of the epithelium is deemed to play a pivotal role in the pathogenesis of sepsis. A neoepitope in cytokeratin 18 (CK18), termed M30 neoantigen, becomes available at an early caspase cleavage event during apoptosis of epithelium-derived cells and is not detectable in vital or necrotic epithelial cells. A monoclonal antibody, M30, specifically recognizes a fragment of CK18 cleaved at Asp396 (M30 neoantigen). We used an enzyme-linked immunosorbent assay (ELISA) to measure M30 antigen levels in the sera of 15 septic patients. Healthy humans and critical ill patients suffering from severe trauma served as controls. Mann-Whitney U test was used to calculate significance, and a P value of <0.01 was considered to be statistically significant. Serum levels of the CK18 neoepitope M30 were significantly increased in septic patients (236.88 +/- 47.4 U/L) versus trauma (97.2 +/- 17.1 U/L) and healthy controls (66.9 +/- 9.2 U/L) (P < 0.01 and P < 0.008, respectively). The increased serum level of the CK18 neoepitope in septic patients indicates a heightened apoptotic turnover in epithelial cells as compared with trauma patients and healthy controls. Interestingly, nonsurviving trauma patients exhibited a significant increase in the M30 neoantigen as compared with survivors and healthy controls (P < 0.003 and P < 0.002, respectively). The detection of CK18 neoepitope M30 in the serum might be a useful marker in tracing apoptotic epithelium in septic patients.
Enzymatic Solubilization of Coal (2017)

Direct formation and recovery of a water-soluble product from microbial action on solid coal was first reported by Cohen and Gabriele. Coal biosolubilization has become a subject of increasing interest as a possible approach to the utilization of low-rank coals. This chapter presents the results of analytical chemistry and biochemistry experiments that have been applied to the characterization of biosolubilized products and enzymatic systems studied in our laboratories. Coal rank is an important factor in determining the extent and rate of microbial solubilization. Experiments in several laboratories indicate that low-rank coals, such as leonardite and lignite, are more amenable to biosolubilization than are the higher-rank subbituminous and bituminous coals. The process of solubilization was evident within 24 h and continued with the amount of bioextract increasing over several days until many of the coal pieces were completely liquefied. The bioextract was generally harvested from the fungal cultures after 5 days, freeze-dried, and stored desiccated at room temperature.
Prevalence of Salmonella spp on conventional and organic dairy farms (2004)

Salmonella spp were isolated from > 90% of dairy farms; however, 25% of farms accounted for > 75% of Salmonella-positive samples. This information is critical for the direction of intervention strategies to decrease the prevalence of Salmonella spp on dairy farms.
IrO<sub>2</sub>-TiO<sub>2</sub>: A High-Surface-Area, Active, and Stable Electrocatalyst for the Oxygen Evolution Reaction (2017)

The utilization and development of efficient water electrolyzers for hydrogen production is currently limited due to the sluggish kinetics of the anodic process—the oxygen evolution reaction (OER). Moreover, state of the art OER catalysts contain high amounts of expensive and low-abundance noble metals such as Ru and Ir, limiting their large-scale industrial utilization. Therefore, the development of low-cost, highly active, and stable OER catalysts is a key requirement toward the implementation of a hydrogen-based economy. We have developed a synthetic approach to high-surface-area chlorine-free iridium oxide nanoparticles dispersed in titania (IrO2-TiO2), which is a highly active and stable OER catalyst in acidic media. IrO2-TiO2 was prepared in one step in molten NaNO3 (Adams fusion method) and consists of ca. 1–2 nm IrO2 particles distributed in a matrix of titania nanoparticles with an overall surface area of 245 m2 g–1. This material contains 40 molM % of iridium and demonstrates improved OER activity and stability in comparison to the commercial benchmark catalyst and state of the art high-surface-area IrO2. Ex situ characterization of the catalyst indicates the presence of iridium hydroxo surface species, which were previously associated with the high OER activity. Operando X-ray absorption studies demonstrate the evolution of the surface species as a function of the applied potential, suggesting the conversion of the initial hydroxo surface layer to the oxo-terminated surface via anodic oxidation (OER regime).
Antioxidant activities and determination of phenolic compounds isolated from oriental plums (Soldam, Oishiwase and Formosa) (2012)

The purposes of this study were to determine phenolic compounds and to evaluate antioxidant activities of plums (Soldam, Oishiwase and Formosa). Soldam contains the highest amount of total phenolics among cultivars (Formosa: 4.0%, Oishiwase: 3.3%, Soldam: 6.4% for total phenolic) as well as the total flavonoids of which constituents were mainly myricetin and anthocyanidin. The antioxidant activities were measured by DPPH, ABTS radical scavenging, and SOD-like activities. The DPPH radical scavenging activity of Korean plum extracts (200 µg/mL) showed more than 43%, and the Soldam turned out to be the highest : ID(50) value: 160-177 µg/mL for Formosa and Oishiwase; 58-64 µg/mL for Soldam. The ABTS radical scavenging activity of Korean plum extracts (200 µg/mL) was found to be more than 50%. The SOD-like activity of Korean plum extracts (200 µg/mL) showed more than 70%. Among three kinds of cultivars, Soldam had the highest antioxidant activity. The nitrite scavenging activity of Soldam was 61.5%, which is the highest, compared with that of the other cultivars, about 50%. From these results, Korean plums turned out to be phytochemical rich fruit as well as to show high antioxidant activities.
A High-Speed Inkjet-Printed Microelectromechanical Relay With a Mechanically Enhanced Double-Clamped Channel-Beam (2016)

We report a high-speed inkjet-printed three-terminal microelectromechanical (MEM) relay with a double-clamped beam that exploits the enhanced stiffness of the double-clamped structure to improve electrical performance. To minimize mechanical delay and pull-in voltage, the contact gap between the channel-beam and drain, and the stiffness of the beam and shape of the drain was carefully designed and optimized through a 3-D finite element simulation. The double-clamped beam prevents stiction-related failure between the channel-beam and drain despite the contact gap being only 370 nm for a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$> 500~\mu \text{m}$ </tex-math></inline-formula> long beam. The resulting printed relay delivers a turn-ON delay of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$8~\mu \text{s}$ </tex-math></inline-formula> at a gate voltage of 10 V, a pull-in voltage of only 7.2 V, immeasurable off-leakage, excellent subthreshold swing, and a small hysteresis window of 2 V without any bending or collapsing of the beam. The device also shows reliable operation over <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$10^{5}$ </tex-math></inline-formula> cycles while maintaining a high ON/OFF ratio of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$10^{8}$ </tex-math></inline-formula> , and extremely low ON-state resistance of 3.7 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\Omega $ </tex-math></inline-formula> . [2016-0180]
Organic thin film transistors using 6,13-bis(tri-isopropylsilylethynyl)pentacene embedded into polymer binders (2009)

The active channel material of an organic thin film transistor (OTFT), 6,13-bis(tri-isopropylsilylethynyl)pentacene (TIPS pentacene), is a functionalized pentacene designed to enhance both the solubility and solid-state packing of the pentacene. In this work, in order to improve device performance, three types of polymer binders—poly(α-methylstyrene) (PAMS), poly(4-vinylbiphenyl) (PVBP), and poly(triarylamine) (PTAA)—were employed to fabricate OTFT devices with organic soluble TIPS pentacene. These binders improved film formation in a large area uniformly and helped the TIPS pentacene to form a stronger binding between source/drain electrodes onto dielectric layer. Thus, device performance was highly improved due to improvement of interfacial contact and an increase in the charge transfer in the active channel. OTFTs using TIPS pentacene with PAMS, PVBP, and PTAA for field effect mobilities in the saturation regime have 5×10−3, 8×10−3, and 2.7×10−2 cm2/V s, respectively.
Kneading optimization by means of experimental design : an application to Eflucimibe / gamma-cyclodextrin complexation (2004)

International audience
Survival of the fittest: a role for phage‐encoded eukaryotic‐like kinases (2011)

Phages are often thought of as mortal enemies of bacteria. This dynamic relationship has led to the evolution of a number of processes in bacteria designed to defeat these attacks. Examples of these include blocking phage attachment, CRISPR, and restriction modification systems. Temperate phages provide another source of protection by excluding infection of heterologous phage, thwarting phage production and further infection. This strategy protects the rest of the bacterial population from attack. The lambdoid phage 933W, a source of the genes encoding Shiga toxin in the highly pathogenic O157:H7 enterohemorrhagic E. coli strain, also carries a gene encoding a eukaryotic-like tyrosine kinase, Stk. In this issue of Molecular Microbiology, Friedman et al. (2011) show that Stk, through its kinase activity, excludes infection by another lambdoid phage HK97. This exclusion is very specific as it does not affect a number of other lambdoid phages. HK97 contributes to its own demise by expressing the product of an open reading frame, orf41, which is required for Stk activation. The authors further show that autophosphorylation increases the stability of Stk and suggest that autophosphorylation contributes to Stk activity. Whether or not this exclusion activity provides a selective advantage through maintenance of Stk activity is yet to be explored.
Purification of the <i>Cucumber Necrosis Virus</i> Replicase from Yeast Cells: Role of Coexpressed Viral RNA in Stimulation of Replicase Activity (2004)

Purified recombinant viral replicases are useful for studying the mechanism of viral RNA replication in vitro. In this work, we obtained a highly active template-dependent replicase complex for Cucumber necrosis tombusvirus (CNV), which is a plus-stranded RNA virus, from Saccharomyces cerevisiae. The recombinant CNV replicase showed properties similar to those of the plant-derived CNV replicase (P. D. Nagy and J. Pogany, Virology 276:279-288, 2000), including the ability (i). to initiate cRNA synthesis de novo on both plus- and minus-stranded templates, (ii). to generate replicase products that are shorter than full length by internal initiation, and (iii). to perform primer extension from the 3' end of the template. We also found that isolation of functional replicase required the coexpression of the CNV p92 RNA-dependent RNA polymerase and the auxiliary p33 protein in yeast. Moreover, coexpression of a viral RNA template with the replicase proteins in yeast increased the activity of the purified CNV replicase by 40-fold, suggesting that the viral RNA might promote the assembly of the replicase complex and/or that the RNA increases the stability of the replicase. In summary, this paper reports the first purified recombinant tombusvirus replicase showing high activity and template dependence, a finding that will greatly facilitate future studies on RNA replication in vitro.
ChemInform Abstract: 1,2‐ ODER 1,4‐ADDITION BEI DER UMSETZUNG VON CHINOLINEN MIT ORGANO‐LITHIUMVERBINDUNGEN (1972)

Abstract 4‐Methyl‐chinolin (I) reagiert mit n‐Butyl‐lithium (IIa) und Phenyl‐lithium (IIb) zu den 1,2‐Addukten (IIIa) und (IIIb), die mit Chlorameisensäureäthylester zu den N‐Äthoxycarbonylderivaten (IVa) und (IVb) reagieren.