gebhart/patrepeval huggingface dataset:
Financial engineering, consumer credit, and the stability of effective demand (2007)

This paper examines the macroeconomic implications of recent developments in financial engineering, with particular emphasis on the post-1987 growth of markets for securities backed by credit card, installment, student loan, and home equity receivables. Three linkages of financial engineering to effective demand are identified: (1) funding effects, (2) liquidity preference or speculative effects, and (3) balance sheet or Minsky effects. Data from the Survey of Consumer Finances are used to investigate the importance of asset-backed security-related funding and balance sheet (Minsky) effects in the United States. Evidence is shown that financial engineering has boosted borrowing power at all income levels. The liberal use of expanded borrowing opportunities has fueled the growth of consumption---especially since 1995. However, a secularly rising share of U.S. households have entered the categories of "speculative" or "Ponzi" finance units---a factor that raises doubts about the sustainability of the current spending boom.
The role of the membrane skeleton in concanavalin A-mediated agglutination of human erythrocytes. (1990)

In the erythrocyte membrane, the mobility of band 3 protein, the receptor for concanavalin A (Con A), is drastically reduced by the membrane skeleton. Yet, the vesicles free of membrane skeletal proteins, isolated from the highly agglutinable proteinase-treated cells, are found to be devoid of Con A agglutinability. The vesicles bind Con A in normal amounts, and remain agglutinable with the wheat germ and Ricinus agglutinins. Intracellular entrapment of monospecific antibodies to spectrin and 4.1 protein (two of the major skeletal components of the membrane) is also found to inhibit agglutination by 30-50%. Thus the membrane skeleton appears to play a positive role in the agglutination of the cells with Con A. The anti-ankyrin antibodies are found to be without any effect. The anti-band 3 (cytoplasmic domain) antibodies are also inhibitory to agglutination. Since Con A binding to cells alters the shape responses and deformability of the cells, and the cells resist fragmentation at 49 degrees C, the properties of the whole skeleton, especially spectrin, appear to be changed. The Con A-bound membranes also do not release the complex of spectrin-band 4.1-actin when extracted with a hypotonic medium. It appears that Con A binding leads to interaction of the cytoplasmic domain of the receptor with a skeletal component, possibly spectrin. Subsequent to this, the receptor molecules and the skeletal proteins undergo aggregation in the membrane, which is detected by their crosslinking by an 8.6-A span bifunctional reagent. The contractility believed to be associated with the membrane skeleton may be responsible for the aggregation.
Molecular chaperone HSP90 as a novel target for cancer chemotherapy. (2003)

HSP90 is one of the major molecular chaperones whose expression level increases by environmental stresses. Even under normal conditions, HSP90 is a highly abundant cytosolic protein and is essential for cell viability. HSP90 is involved in the maintenance of appropriate folding and conformation of many cellular functional proteins. These "HSP90 client proteins" are associated with HSP90 and they include a wide variety of signal-transducing proteins that regulate cell growth and differentiation, such as protein kinases and steroid hormone receptors. HSP90 functions in an ATP-dependent manner with other molecular chaperones such as Cdc37 and FKBP52. An HSP90 inhibitor, geldanamycin, binds the ATP-binding pocket of HSP90 and specifically inhibits the essential ATPase activity of HSP90. Thus, treatment of cells with geldanamycin results in inactivation, destabilization, and degradation of HSP90 client proteins. Because HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis, geldanamycin obstructs the proliferation of cultured cancer cells and shows anti-cancer activity in experimental animals. Although the precise mechanism of the effect of HSP90 inhibitors on cancer cells remains to be clarified, HSP90 inhibitors will be potential and effective cancer chemotherapeutic drugs with a unique profile. In fact, a modified geldanamycin with lower toxicity, 17-allylaminogeldanamycin (17-AAG), has been examined in phase I clinic trials with encouraging results.
EventScript (2008)

EventScript is a simple but powerful language for programming reactive processes. A stream of incoming events is matched against a regular expression. Actions embedded within the regular expression are executed in response to the matching of patterns of events. These actions include assigning computed values to variables and emitting output events. The definition of EventScript presented a number of novel and interesting language-design choices. EventScript has an efficient implementation, and has been used in a development environment for complex event-based applications. We have used EventScript to program both small examples and large industrial applications. Readers of EventScript programs find them easy to understand, and are comfortable with the familiar model of matching regular expressions.
PERMEABILITY OF GRANULAR MATERIALS (1970)

This report deals with the first stage of an investigation carried out in the Materials Research Division of the Country Roads Board of Victoria into factors influencing the permeability of granular materials. Details are given of the equipment developed and the method used for the measurement of permeability. The aims of this firs stage are set out together with the experimental results obtained. A discussion on some interesting features contained in the results is also included. /TRRL/
Morphology and Formation Mechanisms of Porous Silicon (2003)

Porous silicon exhibits extremely rich morphological features resulting from a set of very complex reaction processes at the silicon/electrolyte interface. Numerous theories have been proposed since its discovery more than four decades ago, but there is still a lack of complete understanding of the formation mechanisms with respect to the observed morphological details. This paper attempts to provide a conceptual analysis of the various aspects in the morphology and formation mechanisms of porous silicon in light of currently available information on the fundamental reaction processes on silicon electrodes. © 2003 The Electrochemical Society. All rights reserved.
Synthesis of 5-cyanopyrimidines (1974)

H. Kristinsson, J. Chem. Soc., Chem. Commun., 1974, 350a DOI: 10.1039/C3974000350A
Philosophy and Analysis. (1958)

Journal Article Book Reviews Get access Philosophy and Analysis. Edited, with an Introduction, by Margaret Macdonald. (Oxford : Blackwell. 1954. Pp. viii + 296. Price 30s). P. L. Heath P. L. Heath Search for other works by this author on: Oxford Academic Google Scholar The Philosophical Quarterly, Volume 8, Issue 30, January 1958, Pages 86–87, https://doi.org/10.2307/2216867 Published: 01 January 1958
Stimuli and consequences of dendritic release of oxytocin within the brain (2007)

The brain oxytocin system has served as a distinguished model system in neuroendocrinology to study detailed mechanisms of intracerebral release, in particular of somatodendritic release, and its behavioural and neuroendocrine consequences. It has been shown that oxytocin is released within various brain regions, but evidence for dendritic release is limited to the main sites of oxytocin synthesis, i.e. the hypothalamic SON (supraoptic nucleus) and PVN (paraventricular nucleus). In the present paper, stimuli of dendritic release of oxytocin and the related neuropeptide vasopressin are discussed, including parturition and suckling, i.e. the period of a highly activated brain oxytocin system. Also, exposure to various pharmacological, psychological or physical stressors triggers dendritic oxytocin release, as monitored by intracerebral microdialysis within the SON and PVN during ongoing behavioural testing. So far, dendritic release of the neuropeptide has only been demonstrated within the hypothalamus, but intracerebral oxytocin release has also been found within the central amygdala and the septum in response to various stimuli including stressor exposure. Such a locally released oxytocin modulates physiological and behavioural reproductive functions, emotionality and hormonal stress responses, as it exerts, for example, pro-social, anxiolytic and antistress actions within restricted brain regions. These discoveries make oxytocin a promising neuromodulator of the brain for psychotherapeutic intervention and treatment of numerous psychiatric illnesses, for example, anxiety-related diseases, social phobia, autism and postpartum depression.
Displacement Measurement of Derrick Model Base on the Non-Contact Type Video Measurement Technology (2013)

In this paper, a non-contact type video measurement technology is introduced, and the displacements of derrick model are measured by this technology. Then comparative analysis between this measurement results and the finite element analysis results showed that the precision of measurement displacement of derrick model used this technology is good. Therefore, this technology is an effective, convenient, safe, low cost, low labor and a new method of derrick displacement measurement.
Fabrication of Photovoltaic Textiles (2017)

Solar photovoltaic (PV) arrays are providing an increasing fraction of global electrical demand, with an accelerating rate of new installations. Most of these employ conventional glass-fronted panels, but this type of PV array does not satisfy applications that require a light-weight, flexible PV generator. An option discussed in this article is to consider textiles for such solar cell substrates. As explained in this review, combining the choice of PV cell type with the choice of textile offers alternative structures for flexible PV cells. In particular, the relative advantages and disadvantages are contrasted, either forming PV-coated fibres into a fabric, or coating an already formed fabric with the PV materials. It is shown that combining thin-film amorphous silicon PV technology and woven polyester fabric offers one solution to realizing flexible fabric PV cells, using well-understood coating methods from the textile and semiconductor industries. Finally a few applications are presented that are addressed by this approach.
Impact of physical and geometrical parameters on visible light communication links (2017)

This paper studies the impact of various parameters used for modeling indoor VLC channels, considering a mobile user within the confined environment. The main investigated parameters are either physical or geometrical. First, we classically study the impact of optical properties of surface materials. Then, the effect due to the presence of the user body inducing various VLC receiver orientations is analyzed. Finally, different body and furniture sizes and levels of details are also investigated. This study explores whether it is necessary and how to model the channel regarding the studied parameters. The results are established according to VLC link quality and data rate.
Radiotelemetric fetal monitoring during and after open fetal operation. (1993)

Diagnosis and treatment of fetal disease processes has advanced dramatically, but the ability to monitor the fetus in utero remains rudimentary. Open fetal operation provides a unique opportunity to correct life-threatening fetal abnormalities, but it also places the fetus at risk. Continuous intraoperative and post-operative fetal electrocardiographic monitoring may decrease the risk by optimizing fetal and maternal perioperative management. We tested an implantable radiotelemetry device that allowed continuous intraoperative and postoperative fetal electrocardiographic and temperature monitoring. The radiotelemetry device was placed subcutaneously in four fetal sheep at 100 to 112 days' gestation (term equals 145 days). During and after the fetal operation, the monitor reliably and continuously transmitted the analog fetal electrocardiogram and temperature. We then tested a similar device during human fetal operations on both an acute and a chronic basis. The radiotelemetry device permits continuous and reliable fetal monitoring during and after fetal operation and we now consider it essential to the operation. Its use should facilitate optimal fetal and maternal management and improve survival of the fetus.
Segmenting Narrative Text into Coherent Scenes (1994)

This paper describes a quantitative indicator for segmenting narrative text into coherent scenes. The indicator, called the lexical cohension profile (LCP), records lexical cohesiveness of words in a fixed-length window moving word by word on the text. The cohesiveness of words, which represents their coherence, is computed by spreading activation on a semantic network The basic idea of LCP is: (1) if the window is inside a scene, the words in it tend to be cohesive, and (2) if the window is crossing a scene boundary, the words in it tend to be incohesive. Comparison with the scene boundaries marked by a number of subjects shows that hills and valleys of the graph of LCP closely correlates with the human judgements. LCP may provide valuable information for text analysis, especially for resolving anaphora and ellipsis.
Zebrafish<i>zic2a</i>patterns the forebrain through modulation of Hedgehog-activated gene expression (2009)

Holoprosencephaly (HPE) is the most common congenital malformation of the forebrain in human. Several genes with essential roles during forebrain development have been identified because they cause HPE when mutated. Among these are genes that encode the secreted growth factor Sonic hedgehog (Shh) and the transcription factors Six3 and Zic2. In the mouse, Six3 and Shh activate each other's transcription, but a role for Zic2 in this interaction has not been tested. We demonstrate that in zebrafish, as in mouse, Hh signaling activates transcription of six3b in the developing forebrain. zic2a is also activated by Hh signaling, and represses six3b non-cell-autonomously, i.e. outside of its own expression domain, probably through limiting Hh signaling. Zic2a repression of six3b is essential for the correct formation of the prethalamus. The diencephalon-derived optic stalk (OS) and neural retina are also patterned in response to Hh signaling. We show that zebrafish Zic2a limits transcription of the Hh targets pax2a and fgf8a in the OS and retina. The effects of Zic2a depletion in the forebrain and in the OS and retina are rescued by blocking Hh signaling or by increasing levels of the Hh antagonist Hhip, suggesting that in both tissues Zic2a acts to attenuate the effects of Hh signaling. These data uncover a novel, essential role for Zic2a as a modulator of Hh-activated gene expression in the developing forebrain and advance our understanding of a key gene regulatory network that, when disrupted, causes HPE.
The dominant role of low-frequency interaural time differences in sound localization (1992)

Two experiments are described in which listeners judge the apparent directions of virtual sound sources-headphone-presented sounds that are processed in order to simulate free-field sounds. Previous results suggest that when the cues to sound direction are preserved by the simulation, the apparent directions of virtual sources are nearly the same as the apparent directions of real free-field sources. In the experiments reported here, the interaural phase relations in the processing algorithms are manipulated in order to produce stimuli in which the interaural time difference cues signal one direction and interaural intensity and pinna cues signal another direction. The apparent directions of these conflicting cue stimuli almost always follow the interaural time cue, as long as the wideband stimuli include low frequencies. With low frequencies removed from the stimuli, the dominance of interaural time difference disappears, and apparent direction is determined primarily by interaural intensity difference and pinna cues.
Studies on the chemical constituents of flannel mullein (Verbascum thapsus) (1996)

Four compounds, among which one is eregosterol from the alcohol extract of flowers of the plant Verbascum thapsus. This peroxide is obtained for the first time in V.L.plant. As ergosterol peroxide was mainly found in terrestrial fungi, lichens and marine micro-organisms, its possible biogenetic pathway in higher terreatrial plants such as Verbascum deserve further study.
An alternative paclitaxel self-emulsifying microemulsion formulation: preparation, pharmacokinetic profile, and hypersensitivity evaluation. (2006)

Based on the clinical fact that paclitaxel injection (Taxol) frequently causes hypersensitivity reactions, an alternative paclitaxel self-emulsifying microemulsion was studied with phase diagrams, and the prescription of microemulsion formulation was optimized. Regarding Taxol, the pharmacokinetic parameters of microemulsion and hypersensitivity were investigated in rats and guinea pigs, respectively. The results showed that the self-emulsifying microemulsion was made up of tricaproin:tributyrin 1:1 as the oil phase, ethanol as assist, pluronic F68 and lecithin as emulsifier, and formed a mean diameter of 16 +/- 3 nm when diluted with saline. In the pharmacokinetic study, rats were administrated Taxol or paclitaxel microemulsion. Blood samples were collected at definite time intervals, and plasma concentrations of paclitaxel were determined by high-performance liquid chromatography. The area under the curve was significantly higher in the microemulsion group (33 mg.ml(-1).h) than that in the Taxol group (25 mg.ml(-1).h) (P < 0.01). The constant of transport rate of speed, K10 (0.55 h(-1)), was much smaller in the microemulsion group compared with the Taxol group (1.55 h(-l)). The mean retention time was 3.89 h in microemulsion group and 2.52 h in the Taxol group, showing the elimination rate was much slower in the former than in the latter. Compared with Taxol, the paclitaxel microemulsion caused less toxicity and had a longer circulation time in rats.
CyclinG1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance and Inhibition of Bcl-2 Pathway Reverses the Resistance (2017)

CycG1 is a crucial factor in ZM-induced polyploidy resistance, and ABT-263/ZM combination hold therapeutic utility in the CycG1-amplified subset of breast cancer and CycG1, thus, is a promising target in breast cancer.
Perhaloalkyl hypochlorites. V. Perfluoroalkyl borate esters from reactions with boron trichloride (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPerhaloalkyl hypochlorites. V. Perfluoroalkyl borate esters from reactions with boron trichlorideD. E. Young, L. R. Anderson, and W. B. FoxCite this: Inorg. Chem. 1971, 10, 12, 2810–2812Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/ic50106a041https://doi.org/10.1021/ic50106a041research-articleACS PublicationsRequest reuse permissionsArticle Views208Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Alignment of Biological Macromolecules in Novel Nonionic Liquid Crystalline Media for NMR Experiments (2000)

n-Alkyl-poly(ethylene glycol)/n-alkyl alcohol and glucopone/n-hexanol mixtures are shown to form dilute liquid crystalline phases in aqueous solution which are suitable for partial alignment of biological macromolecules in a magnetic field. The constituent compounds are commercially available and inexpensive. The poly(ethylene glycol)-based systems are uncharged and thus insensitive with respect to pH, little sensitive with respect to salt, and tolerant against high protein concentrations. They are demonstrated to be suitable for measurements of residual dipolar couplings in proteins, DNA, and a protein/DNA complex. The stability range of the lamellar phase with respect to temperature was explored for different mixtures and guidelines are provided for the use of these lyotropic systems in NMR spectroscopy.
<i>Helicobacter Pylori in Vivo</i>Diagnosis after Food Intake: Results of Simultaneous [<sup>15</sup>N]Urea Urine and [<sup>13</sup>C]Acetate Breath Tests (2000)

The protocols for 13C and 15N H. pylori tests stipulate that the diagnostic agent should be taken on an empty stomach. It is presumed that food intake prior to the tests leads to less reliable test results due to a prolongation of the gastric residence time of the diagnostic agent urea. This might allow the bacteria to split a higher proportion of urea, resulting in an increased number of false positives. 12 probands received 150mg [15N]urea and 75 mg sodium [13C]acetate in 75 ml orange juice as a test drink. [15N]Urea served as an agent to diagnose gastric H. pylori colonization. The 15N tests were evaluated using a urine sample of the second hour after test start. [13C]Acetate served as a marker of the gastric emptying of water-soluble food including the urea under the influence of food intake. Breath air samples were taken to calculate the gastric emptying half life (EHL) and the apparent resorption time (RT) of the urea. The double tests were carried out four times within four weeks using identical test protocols but different standardized time periods of pretest fasting: overnight, two hours prior to test, one hour prior to test, and no fasting at all. The food intake amount was standardized. Five probands testing positive in the overnight fasting test were also found to be positive in the other test variants with more or less empty stomachs. Seven other probands testing negative after overnight fasting tested negative in the other test variants as well. It is concluded that food intake prior to the test drink does not have much of an influence on the gastric residence time of urea and so on the qualitative H. pylori test results. Due to identical behaviour of [13C]urea and [15N]urea in the stomach, this influence is believed to be independent on the labelling isotope. For survey purpose, no fasting conditions are required for the H. pylori tests.
An Intelligent Maritime Workplace using IT technologies (2008)

IT technologies over the past years have shown a rapid growth, on the contrary this increase of e-commerce and e-work in the maritime industry is not as intense as in any other field. E-commerce and e-work is still at its embryonic stages, however, the annual rate of increase suggest that in very few years this share will have grown dramatically. Thus, it is time to get prepared. The aim of the present paper is to present a new maritime intelligent workplace based weather information system and decision support for high-speed maritime transport. It has been achieved by linking fixed/mobile communications with navigation/positioning, efficient transmission and delivery over the geo-information network. These services will allow the shipmaster to have seamless access to, and interaction with intelligent, customised (route based) rich content multimedia information on the efficient and safe navigation passage for passengers, freights and the environment both on board ship and inland.