gebhart/patrepeval huggingface dataset:
Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells (2005)

To understand the mechanisms by which thrombin induces vascular smooth muscle cell (VSMC) DNA synthesis and motility, we have studied the role of phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR)-S6K1 signaling. Thrombin stimulated the phosphorylation of Akt and S6K1 in VSMC in a sustained manner. Blockade of PI3K-Akt-mTOR-S6K1 signaling by LY-294002, and rapamycin suppressed both thrombin-induced VSMC DNA synthesis and migration. Adenovirus-mediated expression of dominant-negative Akt also inhibited thrombin-induced VSMC DNA synthesis and migration. Furthermore, thrombin induced the expression of Fra-1 in a sustained PI3K-Akt-dependent and mTOR-independent manner in VSMC. Suppression of Fra-1 by its small interfering RNA attenuated both thrombin-induced VSMC DNA synthesis and migration. Thrombin also induced the expression of FGF-2 in a PI3K-Akt-Fra-1-dependent and mTOR-independent manner, and neutralizing anti-FGF-2 antibodies inhibited thrombin-stimulated VSMC DNA synthesis and motility. In addition, thrombin stimulated the tyrosine phosphorylation of EGF receptor (EGFR), and inhibition of its kinase activity significantly blocked Akt and S6K1 phosphorylation, Fra-1 and FGF-2 expression, DNA synthesis, and motility induced by thrombin in VSMC. Together these observations suggest that thrombin induces both VSMC DNA synthesis and motility via EGFR-dependent stimulation of PI3K/Akt signaling targeting in parallel the Fra-1-mediated FGF-2 expression and mTOR-S6K1 activation.
Tridentate ligands containing the SNS donor atom set as a novel backbone for the development of technetium brain-imaging agents (1994)

In developing 99mTc complexes as potential brain-imaging agents, we investigated the coordination chemistry of ligands containing sulfur and nitrogen donor atoms with the general formula R-CH2CH2N(CH2CH2SH)2 (R = C2H5S, (C2H5)2N). These ligands act as tridentate SNS chelates to the TcO3+ core, leaving open one coordination site cis to the oxo group. In reactions with the highly reactive [99TcOCl4]- precursor, this vacancy was occupied by a chlorine atom. When the ligands reacted in the presence of 4-methoxythiophenol, using 99Tc(V)-gluconate as precursor, the vacancy was filled with 4-methoxythiophenol, which acted as coligand. Thus neutral mixed ligand complexes of the general formula [TcO((SCH2CH2)2NCH2CH2R)X], where X = Cl or 4-methoxythiophenol, were synthesized. The complexes were characterized by UV-vis, IR, 1H NMR, crystallographic, and elemental analyses. The crystal structures of 3a (R = C2H5S, X = Cl) and 4b (R = (C2H5)2N, X = 4-methoxythiophenol) demonstrated that the coordination geometry is trigonal bipyramidal with the N1 and Cl or S3 occupying the apical positions and the basal plane defined by the S1 and S2 of the tridentate ligand and the oxo group. The complexes 4a(99mTc) (R = C2H5S, X = 4-methoxythiophenol) and 4b(99mTc) were prepared using 99mTc-glucoheptonate as precursor and were purified by HPLC. Biodistribution in mice showed high initial brain uptake (3.68% and 3.56% dose/organ for 4a(99mTc) and 4b(99m-Tc), respectively). Complex 4b(99mTc) displayed significantly higher brain/blood values and prolonged retention in brain as well. The results suggest that structural modifications based on configurations 4a,b may provide novel 99mTc brain-imaging agents with improved biological characteristics.
Die Aufklärung von Taxin A aus <i>Taxus baccata</i> L. (1982)

The Elucidation of Taxine A from Taxus baccata L. The structure of taxine A, C 35 H 47 NO 10 , the crystalline alkaloid obtained by partition chromatography of the amorphous taxine isolated from taxus baccata L. was elucidated. Partial structures and functional groups were derived from proton and carbon‐13 NMR involving decoupling experiments. Full structure determination of the tricyclic diterpenoid backbone was achieved by single crystal X ‐ray diffractometry. Bond distances and assignments of proton and carbon shifts are given.
The therapeutic uses of cranberry juice (1995)

This article considers the treatment of recurrent cystitis. It examines the evidence for drinking cranberry juice to prevent recurrent urinary tract infections and discusses the nursing issues raised, drawing conclusions from the evidence presented.
euHeart: personalized and integrated cardiac care using patient-specific cardiovascular modelling (2011)

The loss of cardiac pump function accounts for a significant increase in both mortality and morbidity in Western society, where there is currently a one in four lifetime risk, and costs associated with acute and long-term hospital treatments are accelerating. The significance of cardiac disease has motivated the application of state-of-the-art clinical imaging techniques and functional signal analysis to aid diagnosis and clinical planning. Measurements of cardiac function currently provide high-resolution datasets for characterizing cardiac patients. However, the clinical practice of using population-based metrics derived from separate image or signal-based datasets often indicates contradictory treatments plans owing to inter-individual variability in pathophysiology. To address this issue, the goal of our work, demonstrated in this study through four specific clinical applications, is to integrate multiple types of functional data into a consistent framework using multi-scale computational modelling.
A FORMALISM FOR CONTEXT MEDIATION BASED ON FEATURE LOGIC (1999)

This paper describes a formalism for context mediation based on Feature Logic. The formalism enables a distinction to be drawn between integrity and translational aspects of mediation. It is independent of the relational model, though easily used within it. The formalism makes precise the concept of "context" and provides a framework for mediation between disparate data sources.
Modernism VS. Postmodernism: Shepard's <i>The Tooth of Crime </i>and the Discourses of Popular Culture (1987)

Postmodernism and the postmodern condition: one of the salient features of both, recent critics tell us, is the "effacement ... of some key boundaries or separations, most notably the erosion of the older distinctions between high culture and so called mass or popular culture." Such is Fredric Jameson's assessment, and in an important article on Postmodernism he adds that many of the newer Postmodernism are fascinated with the "debased" landscape of advertising, media images, motels and the commercial fabric of the superhighway strip. These Postmodernism no longer "quote" from the popular texts as Joyce and Mahler might have done; rather "they incorporate them, to the point where the line drawn between high art and commercial forms seems increasingly difficult to draw."
Efficient Next Generation Emergency Communications over Multi-Access Edge Computing (2017)

Traditionally, emergency communications between citizens and public authorities relied on legacy telecommunication technologies unable to cope with the agile, rich-media-content communications that mobile users are already using. This is due to the lack of harmonization and interoperable IP-based networking solutions. With the operators currently migrating to broadband IP infrastructures, emergency systems also need to follow this path and adapt their emergency communication platforms to fulfill next generation emergency services regulatory requirements. This becomes even more evident in light of the forthcoming 5G networks, which are envisioned to support an amalgam of diverse applications and services with heterogeneous performance requirements, including mission-critical IoT communication, massive machine-type communication, and gigabit mobile connectivity. Emergency service operators face an enormous challenge in order to synchronize their model of operation with the 5G paradigm. This article studies the challenges that next generation emergency services need to overcome in order to fulfill the requirements for rich-content, real-time, location-specific communications. The concept for next generation emergency communications as described in the project EMYNOS is presented, along with a vision of how this concept can fulfill the 5G requirements for ultra-reliable and ultra-low-latency emergency communications.
Humidity‐Triggered Self‐Healing of Microporous Polyelectrolyte Multilayer Coatings for Hydrophobic Drug Delivery (2015)

Layer‐by‐layer (LbL) self‐assemblies have inherent potential as dynamic coatings because of the sensitivity of their building blocks to external stimuli. Here, humidity serves as a feasible trigger to activate the self‐healing of a microporous polyethylenimine/poly(acrylic acid) multilayer film. Microporous structures within the polyelectrolyte multilayer (PEM) film are created by acid treatment, followed by freeze‐drying to remove water. The self‐healing of these micropores can be triggered at 100% relative humidity, under which condition the mobility of the polyelectrolytes is activated. Based on this, a facile and versatile method is suggested for directly integrating hydrophobic drugs into PEM films for surface‐mediated drug delivery. The high porosity of microporous film enables the highest loading (≈303.5 μg cm −2 for a 15‐bilayered film) of triclosan to be a one‐shot process via wicking action and subsequent solvent removal, thus dramatically streamlining the processes and reducing complexities compared to the existing LbL strategies. The self‐healing of a drug‐loaded microporous PEM film significantly reduces the diffusion coefficient of triclosan, which is favorable for the long‐term sustained release of the drug. The dynamic properties of this polymeric coating provide great potential for its use as a delivery platform for hydrophobic drugs in a wide variety of biomedical applications.
Study on a cluster-chain routing protocol in wireless sensor networks (2008)

The energy constraint and the low power communication requirements amplify the significance of the energy efficient routing protocols in wireless sensor networks (WSNs). The primary aim to design a routing protocol for WSN is to improve the energy efficiency and prolong the network lifetime. In this paper, we propose a cluster-chain routing protocol (CCRP), which adopts a more balanced cluster-head selection algorithm and an improved data transmission mechanism from the cluster-heads to the base station. Simulation results indicate that, for a 100m×100m network with the initial energy 0.5J in each node, the proposed CCRP outperforms LEACH by about 78%, 150% and 130% in terms of rounds when 1%, 50%, and 100% of nodes die, respectively.
The clearance of tetanus toxoid/anti-tetanus toxoid immune complexes from the circulation of humans. Complement- and erythrocyte complement receptor 1-dependent mechanisms. (1988)

The role of complement and its receptor on erythrocytes (CR1) in the physiologic elimination of large immune complexes from the circulation of humans was assessed. Large radiolabeled soluble tetanus toxoid- anti-tetanus toxoid complexes were injected i.v. into three normal individuals and three patients with SLE. These complexes were prepared in antibody excess and were 45S in size, fixed C and bound to E CR1 in vitro. The percentage of complexes bound in vitro was directly proportional to CR1 number/E in four normal subjects and three SLE patients. After i.v. injection into normal subjects, complexes were cleared rapidly, with a monoexponential rate constant (10.3 to 11% complexes cleared/min). In the SLE patients, clearance was best explained by two phases: the first occurred within the first minute indicating immediate trapping of a fraction of the complexes (19.5 to 25.3% of injected complexes trapped), the second was monoexponential and was similar to the normal range. A large fraction of complexes bound within the first minute to E in vivo; the percentage of binding was variable, ranging from 16.3% to 71.5% and was related to E CR1 number. In a second study complexes were injected that had been attached to autologous E by opsonization with C in vitro. Their elimination was similarly monoexponential, except in one SLE patient in whom there was significant initial trapping (30.9%). A fraction of these complexes were released from E within the first minute, the percentage release being greatest in the patient with the lowest CR1 number (81.4%). E bearing immune complexes remained in the circulation and were not transiently sequestered in the liver or spleen. This is the first study of the clearance of soluble immune complexes in vivo in humans and shows that C and CR1 on E participate in immune complex clearance reactions, and that abnormal clearance can be detected in the form of rapid removal of immune complexes from the circulation.
Synthesis and Characterization of Potential Efficient Electroluminescent Materials: 2-Phenyl-5-[4-(4-phenylamino-2<i>H</i>-1,2,3-triazol-2-yl)]phenyl-1,3,4-oxadiazole Derivatives (2006)

Abstract Recently, 1,3,4-oxadiazole-based on heterocyclic compounds were investigated as electroluminescent materials. In this work, we first introduce 1,2,3-triazole to synthesize a series of 1,3,4-oxadiazole–1,2,3-triazole hybrids derivatives as potential electroluminescent materials and explore the effect of modification of the 1,2,3-triazole moiety. The λmax values of the UV–vis of 1,3,4-oxadiazole–1,2,3-triazole hybrids are promoted to longer wavelengths (340–350 nm) than the traditional 1,2,3-triazole derivatives (280–330 nm) in solutions and have a bathochromic shift to 350–360 nm in THF solution. The λmax values of the photoluminescence (PL) spectra are in the range 406–480 nm in solutions. Compound 7h evaporated to form films on quartz substrates, had a maximum at 455 nm and showed a red-shift (≈40 nm) with respect to the solution spectrum. The solution fluorescence quantum yields (Φf) were measured, all of which fell into the range 0.65–0.76, and were determined relative to that of 2-phenyl-5-(4-biphenyl)-1,3,4-oxadiazole in benzene (Φf = 0.80). 1,3,4-Oxadiazole–1,2,3-triazole hybrids derivatives show unclearly reversible reduction processes in cyclic voltammogram measurements. Following spectroscopic studies and observation of the electrochemical behaviors, 1,3,4-oxadiazole–1,2,3-triazole derivatives were determined to be highly potential efficient blue electroluminescent materials.
Bitter Rue (1974)

Journal Article Bitter Rue Get access Virginia Peterson Virginia Peterson Search for other works by this author on: Oxford Academic PubMed Google Scholar Social Work, Volume 19, Issue 2, March 1974, Page 217, https://doi.org/10.1093/sw/19.2.217-a Published: 01 March 1974
Predicting total body water and extracellular fluid volumes from bioelectrical measurements of the human body. (1992)

Two biological impedance analyzers, a 50 kHz (RJL) and 20-100 kHz (BMA) instrument, and a total body electrical conductivity (TOBEC) instrument were used to estimate total body water (TBW), extracellular (ECF) and intracellular (ICF) fluid volumes by repeated measurements of 16 normal men (19-38 years old) to assess which, if any, would provide the best estimates. At 3-week intervals, TBW was determined by deuterium dilution, ECF by bromide dilution, ICF by difference (TBW-ECF) and lean body mass by density. Prediction equations were obtained by regression; predicted values for the body fluid volumes were calculated and the results were statistically evaluated. Both the TOBEC and the BMA provided rapid and reliable estimates for body fluid volumes with standard errors of the estimates of about 0.5-1.1 L for ECF, 1.0-1.8 L for TBW, and 1.0-1.3 L for ICF. Part of the error was attributable to standard tracer-dilution methods.
Phase Locked Loops (2005)

Abstract Phase‐locked loops (PLLs) are frequently used in RF and microwave telecommunication systems and measurement equipment to implement various circuits from carrier recovery to frequency synthesis. The goal of this article is to survey the theory and the most important applications of phase‐locked loops. The main emphasis was placed on the analog PLL theory and frequency synthesis. The former is relatively easy to understand and is the basis of every other PLL analysis. The latter is crucial in RF and microwave engineering since frequency synthesizers are used almost everywhere to generate the signals required in the different applications. The PLL article is organized as follows. Section 1 is devoted to the analog PLL theory. First the baseband model is developed and the linear theory of analog PLL (tracking, modulation, and noise) is discussed. Finally, the most important nonlinear effects (acquisition, cycle slips, hangup) are surveyed. Section 2 discusses the most common PLL applications. Section 3 is devoted to frequency synthesis, where both the sampling (sample‐and‐hold‐type phase detector) and charge‐pump (phase–frequency detector with charge‐pump) PLLs are considered. These phase detectors are edge‐triggered circuits; the discrete‐time operation makes the analysis of these PLLs very complex. The problem of discrete‐time operation arising from the application of edge‐triggered circuits is discussed and design methods are given.
1991 Steven A. Coons Award Lecture (1992)

article Free Access Share on 1991 Steven A. Coons Award Lecture Author: Andries van Dam View Profile Authors Info & Claims ACM SIGGRAPH Computer GraphicsVolume 26Issue 3Aug. 1992 pp 205–208https://doi.org/10.1145/142413.142431Online:01 August 1992Publication History 1citation96DownloadsMetricsTotal Citations1Total Downloads96Last 12 Months4Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Neural-network-based motor rolling bearing fault diagnosis (2000)

Motor systems are very important in modern society. They convert almost 60% of the electricity produced in the US into other forms of energy to provide power to other equipment. In the performance of all motor systems, bearings play an important role. Many problems arising in motor operations are linked to bearing faults. In many cases, the accuracy of the instruments and devices used to monitor and control the motor system is highly dependent on the dynamic performance of the motor bearings. Thus, fault diagnosis of a motor system is inseparably related to the diagnosis of the bearing assembly. In this paper, bearing vibration frequency features are discussed for motor bearing fault diagnosis. This paper then presents an approach for motor rolling bearing fault diagnosis using neural networks and time/frequency-domain bearing vibration analysis. Vibration simulation is used to assist in the design of various motor rolling bearing fault diagnosis strategies. Both simulation and real-world testing results obtained indicate that neural networks can be effective agents in the diagnosis of various motor bearing faults through the measurement and interpretation of motor bearing vibration signatures.
Choline-stabilised orthosilicic acid added for nutritional purposes to food supplements (2009)

Orthosilicic acid [Si(OH)4] is the major silicon species present in drinking water and other liquids, including beer, and is the most readily available source of silicon to man. The essentiality of silicon for man has not been established and a functional role for silicon in\nman has not yet been identified. The bioavailability of silicon under the form of orthosilicic acid has been proven for cholinestabilised orthosilicic acid. Acute oral toxicity studies in male and female rats as well as mice have been performed. The calculated mean LD50 value for ch-OSA exceeds (for both animal species) 5000 mg/kg bw.\nConcerning the acute oral toxicology of choline, an LD50 value of 6640 mg/kg bw as choline chloride was found. Subchronic toxicity studies on ch-OSA were conducted both in animals (rodents and mammals) and humans (supplementation studies). No adverse effects were observed.\nThe proposed dosage of ch-OSA in food supplements is 5 to 10 mg silicon/day (equivalent to 0.083-0.17 mg silicon/kg bw/day for a 60 kg person). The equivalent intake of choline amounts to 101-203 mg choline/day for the ch-OSA liquid, and to 117-234 mg choline/day for\nthe ch-OSA pellets. This results in an intake of 135-272 mg choline chloride/day for ch-OSA liquid and of 157-314 mg choline chloride/day for ch-OSA pellets. The European Food Safety Authority estimated the typical dietary intake of silicon to be 20-50 mg/day, corresponding to 0.3-0.8 mg silicon/kg bw/day for a 60 kg person, and concluded that\nthese intakes are unlikely to cause adverse effects. The Panel concludes that silicon is bioavailable from choline-stabilised orthosilicic acid and that its use in supplements, at the proposed use levels of the source, is of no safety concern provided that the upper level for choline is not exceeded.
The Dialectical Treatment of Life and Death in Miguel de Unamuno's "Poesías" (1991)

Unamuno's Poes?as, published in 1907, marks a departure from con ventional poetic tradition. Unamuno combines poetry with philosophy, but he goes further. This writer strains beyond philosophy to the object for which philosophy exists: The human being (Nozick 203). The issues, for Miguel de Unamuno, become personal questions. A new form of poetic expression is born of the need to articulate these personal philosophical questions. Unamuno's rich, dramatic spiritual reali ty takes the form of an open dialectic. His poetry becomes a vital activity with counterforces and conflicting voices. He uses a poetic voice that, in stead of narrating, leads the reader through a constantly changing course of personal dialogue. Ironically, what may have made this work seem inac cessible to many a reader in the past may be what makes Poes?as a precur sory work in the sense that it was to influence later poets: Unamuno experi mented with multiple voices, plurality in point of view, and dialectical treatment of theme, creating a literary experience that challenges the reader to interact with the author. The following analysis, which treats the most discussed Unamunian concern, that of human mortality, illustrates a dialectic of opposing attitudes toward life and death expressed by voices known since Blanco Aguinaga's El Unamuno contemplativo as agonic and contemplative. Even in this brief analysis it is evident that the mean ing of any verse is generated by both its presence and its participation in the whole. Therein lies the complexity of the reader's task. According to Carlos Paris, Miguel de Unamuno always felt himself
Generative, discriminative, and ensemble learning on multi-modal perceptual fusion toward news video story segmentation (2005)

News video story segmentation is a critical task for automatic video indexing and summarization. Our prior work has demonstrated promising performance by using a generative model, called maximum entropy (ME), which models the posterior probability given the multi-modal perceptual features near the candidate points. We investigate alternative statistical approaches based on discriminative models, i.e. support vector machine (SVM), and ensemble learning, i.e. boosting. In addition, we develop a novel approach, called BoostME, which uses the ME classifiers and the associated confidence scores in each boosting iteration. We evaluated these different methods using the TRECVID 2003 broadcast news data set. We found that SVM-based and ME-based techniques both outperformed the pure boosting techniques, with the SVM-based solutions achieving even slightly higher accuracy. Moreover, we summarize extensive analysis results of error sources over distinctive news story types to identify future research opportunities.