gebhart/patrepeval huggingface dataset:
<title>Generic models for rapid calculation of target signatures</title> (1991)

A method for rapidly generating target signatures with limited user interaction and limited computing resources is presented. Simple parameterized generic models are used to represent classes of targets. Within the limits of the allowable parametric variation, as many steps as possible in determining the signature are precomputed. Examples are given of generic models of bridges and dams.
Identification of polymorphisms in the human 11beta‐hydroxysteroid dehydrogenase type 2 gene promoter: functional characterization and relevance for salt sensitivity (2007)

Reduced activity of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) plays a role in essential hypertension and the sensitivity of blood pressure to dietary salt. Nonconservative mutations in the coding region are extremely rare and do not explain the variable 11beta-HSD2 activity. We focused therefore on the 5'-regulatory region and identified and characterized the first promoter polymorphisms. Transfections of variants G-209A and G-126A into SW620 cells reduced promoter activity and affinity for activators nuclear factor 1 (NF1) and Sp1. Chromatin immunoprecipitation revealed Sp1, NF1, and glucocorticoid receptor (GR) binding to the HSD11B2 promoter. Dexamethasone induced expression of mRNA and activity of HSD11B2. GR and/or NF1 overexpression increased endogenous HSD11B2 mRNA and activity. GR complexes cooperated with NF1 to activate HSD11B2, an effect diminished in the presence of the G-209A variant. When compared to salt-resistant subjects (96), salt-sensitive volunteers (54) more frequently had the G-209A variant, higher occurrence of alleles A4/A7 of polymorphic microsatellite marker, and higher urinary ratios of cortisol to cortisone metabolites. First, we conclude that the mechanism of glucocorticoid-induced HSD11B2 expression is mainly mediated by cooperation between GR and NF1 on the HSD11B2 promoter and, second, that the newly identified promoter variants reduce activity and cooperation of cognate transcription factors, resulting in diminished HSD11B2 transcription, an effect favoring salt sensitivity.
Optical constants of methyl-pentaphenylsilole by spectroscopic ellipsometry (2002)

The optical properties of 1-methyl-1,2,3,4,5-pentaphenylsilole thin films grown on silicon substrate were investigated using spectroscopic ellipsometry (SE). Accurate refractive index n and extinction coefficient k, in the wavelength range of 250 to 800 nm, were determined. Sellmeier equations, amorphous semiconductor model, and a three-oscillator classical Lorentz model were used to fit the data in different spectral ranges. A band gap of 2.78 eV and uv absorption peaks at 368 and 263 nm were derived from the SE spectrum. Additionally, the absorption spectra near the major band edges show optical properties similar to that of an amorphous semiconductor.
Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis (2015)

AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute’s panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration.
Untersuchungen zur Acetylen‐Herstellung durch Methan‐ und Leichtbenzin‐Spaltung (1968)

Abstract Für eine optimale Acetylen‐Konzentration in den bei der Methan‐ und Leichtbenzin‐Spaltung entstehenden Gasen sind die Brennerkonstruktion und die Wahl der Reaktionsbedingungen von entscheidender Bedeutung. In diesem Beitrag wird gezeigt, wie durch systematische Untersuchungen des Reaktionsablaufes im Acetylen‐Brenner sowie der wichtigsten Einflußgrößen auch bei diesem technisch bereits ausgereiften Verfahren noch Verbesserungen möglich sind.
<i>Ras</i> involvement in cells transformed with 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) <i>in vitro</i> and with <i>N</i>-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide <i>in vivo</i> (1992)

N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) administration to rats followed by sodium saccharin results in transitional cell carcinomas of the bladder, of which 24% harbor an activated H-ras gene. Since 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) is the mutagenic and carcinogenic metabolite of FANFT in vivo, we wished to examine ras activation in in vitro ANFT-transformed rat bladder epithelial cells as well as four cell lines established in culture from in vivo FANFT-induced rat bladder tumors. Screening by Western blotting revealed no enhanced levels of p21ras in ANFT-transformed cells nor in cells established in culture from FANFT-induced rat bladder carcinomas. Further investigations using immunohistochemical staining with a different pan-reactive p21 monoclonal antibody (Cetus Corporation) specific for this method, however, showed two groups of cells from FANFT-induced rat bladder tumors had enhanced immunoreactivity. Apart from this, p21ras expression of most of the cells groups varied little from the controls. We examined the reported hot spots (exons 1 and 2) of each of the ras genes (H-, K- and N-ras) by direct sequencing of amplified DNA. No mutations were present. We conclude, therefore, that ANFT transformation of primary rat bladder epithelial cells in vitro may not in this case be mediated by ras activation, although this is difficult to determine since others have observed that optimal culture conditions can select for certain populations of cells without ras activation.
Isolation and Chemical Characterization of Polysaccharides from Iwatake,<i>Gyrophora esculenta</i>Miyoshi (1996)

A heteropolysaccharide and a beta-D-glucan were isolated from a lichen, Gyrophora esculenta Miyoshi (Iwatake), by cold water and alkali extractions, respectively. The chemical properties of purified polysaccharides were examined by acid hydrolysis, methylation, and GC-MS. The heteropolysaccharide is a highly branched galactomannan-type polysaccharide, containing an alpha-(1->6)-linked D-mannan backbone, and the glucan is a linear (1->6)-beta-D-glucan. With regard to the antitumor activity, both the galactomannan and (1->6)-beta-D-glucan had moderate inhibition activities on Sarcoma 180, but lower than those of branched (1->3)-beta-D-glucans.
Chapter 8. The halogens and noble gases (1995)

E. G. Hope, Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem., 1995, 92, 103 DOI: 10.1039/IC9959200103
Localization of trapping of 6-[18F]fluoro-L-m-tyrosine, an aromaticL-amino acid decarboxylase tracer for PET (1999)

The purpose of this study was to address four major questions regarding 6-FMT, a noncatecholic PET tracer for AAAD: 1) Where is the specific uptake of 6-FMT? 2) Why does it accumulate where and to the degree that it does? 3) How does its uptake differ from that of fluoroDOPA globally? and 4) Does its regional uptake differ significantly from that of fluoroDOPA? High-resolution PET scans were obtained in three rhesus monkeys using 6-FMT and in two of them using fluoroDOPA. Anatomic distribution was analyzed visually and quantitative uptake of 6-FMT was compared with published regional decarboxylase activity and monoamine neurotransmitter concentrations. In addition to high uptake in the dopamine-rich striatal nuclei, there was specific uptake of 6-FMT in brain regions which have little dopaminergic innervation but which have other amines in significant concentration. 6-FMT uptake correlated best with regional AAAD activity (r = 0.97). It correlated slightly less well with the sum of catecholamine and indolamine neurotransmitter concentrations, but does not correlate with dopamine concentration. The uptake of 6-FMT is greater than that of fluoroDOPA, with only slight differences in their regional distributions. Radiolabeled analogs of DOPA are often implicitly or explicitly regarded as tracers for presynaptic dopaminergic function. However, localization of these tracers more broadly includes many regions with relatively high concentrations of norepinephrine and serotonin. This may be especially important in diseases or experimental states in which dopaminergic neurons are selectively reduced, and may allow for the study of nondopaminergic neuronal systems in vivo with this tracer.
The International Labor Office (1930)

Essay| January 01 1930 The International Labor Office: A Criticism Matthew Woll Matthew Woll Vice President, American Federation of Labor Search for other works by this author on: This Site PubMed Google Scholar Current History (1930) 31 (4): 683–689. https://doi.org/10.1525/curh.1930.31.4.683 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Matthew Woll; The International Labor Office: A Criticism. Current History 1 January 1930; 31 (4): 683–689. doi: https://doi.org/10.1525/curh.1930.31.4.683 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1930 by The Regents of the University of California1930 Article PDF first page preview Close Modal You do not currently have access to this content.
ChemInform Abstract: Generation of Homochiral Aziridinium Ion Intermediates Derived from 2, 3‐Epoxy Amines: Regiospecific Nucleophilic Trapping with Nitrogen Nucleophiles. Application in the Synthesis of Novel Morpholinosphingolipid Analogues with Potential Glucosylceramide Synthase Inhibitory Activity. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Surface electromyography shows increased mirroring in Parkinson's disease patients without overt mirror movements (2006)

Patients with Parkinson's disease (PD) may present mirror movements (MM). Transcranial magnetic stimulation data indicate that these movements reflect an abnormal enhancement of the "physiological mirroring" that can be observed in healthy adults during complex and effortful tasks. It was hypothesized that, in PD, enhanced mirroring is caused by a failure of basal ganglia output to support the cortical network that is responsible for the execution of strictly unimanual movements. If so, it is likely that subtle alterations of voluntary unimanual motor control are also present in PD patients without overt MM. We tested this hypothesis by using surface electromyographic (EMG) techniques in 12 mildly to moderately affected PD patients without overt MM, and in 2 control groups (12 age-matched and 10 young healthy volunteers). Subjects performed unilateral phasic thumb abduction during a sustained tonic contraction of the opposite abductor pollicis brevis. All patients were tested on dopaminergic therapy. On a separate day, 7 of 12 patients were re-tested after withdrawal of medication. During this task, involuntary mirror-like increase in surface EMG of the tonically abducting thumb was significantly larger in PD patients than in age-matched or young healthy volunteers. Off therapy, mirroring was slightly greater than on medication, although this difference was not significant. Our findings suggest that dysfunction of unimanual motor control is a general feature of PD. It is likely that this deficient movement lateralization contributes to an impairment of nonsymmetrical bimanual movements in PD.
Selective formation of methanol from synthesis gas over palladium catalysts (1978)

It is reported that hydrogenation of CO over supported Pd catalysts produces methanol in high selectivity within the temperature-pressure regime where CH/sub 3/OH formation is thermodynamically allowed. The same behavior was found for Pt and Ir as well, but at lower rates. The mechanism of CH/sub 3/OH formation on Pd is discussed. 3 tables, 33 references. (DLC)
Amplifier First-Stage Criteria for Avoiding Slew-Rate Limiting (1986)

on compare le critere d'amplificateur audiofrequence, le critere d'amplification impulsionnel et la limite de Leach
Electrical Characterization of Aluminum-Oxynitride Stacked Gate Dielectrics Prepared by a Layer-by-Layer Process of Chemical Vapor Deposition and Rapid Thermal Nitridation (2002)

2002 International Conference on Solid State Devices and Materials,Electrical Characterization of Aluminum-Oxynitride Stacked Gate Dielectrics Prepared by a Layer-by-Layer Process of Chemical Vapor Deposition and Rapid Thermal Nitridation
The Application of the Compensated Current Comparator to the Calibration of Current Transformers at Ratios Less than Unity (1969)

A technique is described for extending the range of the compensated current comparator so that it may be used for calibrating current transformers at ratios both greater and less than 1/1. The concept of providing compensation windings for both the primary and secondary ratio windings is introduced and a new method of correcting for the capacitance error due to burden is presented. Details on how a compensated current comparator previously developed for ratios from 1/1 to 240/1 may be adapted for this purpose are discussed and results of measurements at ratios down to 0.01/1 with this comparator are given.
An Overview to the BMBF‐Leitprojekt ADAPTRONIK (2000)

In 1997 BMBF, within the framework of an idea competition for future-oriented key technologies and their industrial utilization, called for project proposals from industries and research for so-called “Leitprojekts”. An independent group of experts selected few project proposals from the many submitted, and proposed them to BMBF for promotion. One of these projects is the BMBF-Leitprojekt ADAPTRONIK which is introduced in this paper. The Leitprojekt ADAPTRONIK which consists of 24 partners from industry and research institutes and is conducted under the responsibility of the Deutsches Zentrum für Luft- und Raumfahrt e.V. (DLR) in Brunswick, focuses on the structure-conforming integration of piezoelectronic fibers and patches in structures for lightweight construction. It is aimed at active vibration and noise reduction, contour deformation and micro-positioning in the very sense of adaptronics in various industrial applications. The project targets are prototype assemblies from the fields of automotive industry, rail vehicles, mechanical engineering, medical engineering, and aerospace.
The histone deacetylase inhibitor, PXD101, potentiates bortezomib‐induced anti‐multiple myeloma effect by induction of oxidative stress and DNA damage (2007)

Clinical trials have shown the high anti-myeloma activity of the proteasome inhibitor bortezomib. The present study examined the activity of bortezomib combined with PXD101, a histone deacetylase inhibitor, against multiple myeloma (MM) and osteoclastogenesis. Treatment of myeloma cell lines with combinations of bortezomib and PXD101 led to synergistic inhibition of proliferation and induction of cell death. The combination significantly decreased the viability of primary human CD138(+) myeloma cells but not of bone marrow mononuclear cells. Further studies showed a dose-dependent activation of caspases-3, -8 and -9 and nuclear fragmentation in myeloma cells. Bortezomib/PXD101 treatment markedly triggered reactive oxygen species (ROS) generation that was accompanied by p53, H2A.X and p38-mitogen-activated protein kinase phosphorylation. ROS generation could be blocked by the free radical scavenger N-acetyl-L-cysteine. The combination of bortezomib and PXD101 also resulted in synergistic inhibition of osteoclast formation. In conclusion, bortezomib and PXD101 have different molecular targets. The combination induces cell death in myeloma cells via ROS-mediated DNA damage and also inhibits osteoclastogenesis. Therefore, this study provides the rationale for the clinical evaluation of bortezomib combined with PXD101 in patients with MM.
Discovery of Novel Non-Peptide CCR1 Receptor Antagonists (1999)

Ligands for the CCR1 receptor (MIP-1alpha and RANTES) have been implicated in a number of chronic inflammatory diseases, most notably multiple sclerosis and rheumatoid arthritis. Because these ligands share a common receptor, CCR1, we sought to discover antagonists for this receptor as an approach to treating these disorders. A novel series of 4-hydroxypiperidines has been discovered by high throughput screening (HTS) which potently inhibits the binding of MIP-1alpha and RANTES to the recombinant human CCR1 chemokine receptor. The structure-activity relationships of various segments of this template are described as the initial HTS lead 1 was optimized synthetically to the highly potent receptor antagonist 6s. This compound has been shown to have at least 200-fold selectivity for inhibition of CCR1 over other human 7-TM receptors, including other chemokine receptors. In addition, data obtained from in vitro functional assays demonstrate the functional antagonism of compound 6s and structurally related analogues against the CCR1 receptor in a concentration dependent manner. The discovery and optimization of potent and selective CCR1 receptor antagonists represented by compound 6s potentially represent a novel approach to the treatment of chronic inflammatory diseases.
Electrogeneration of cyanomethyl anion from phenylsulphonylacetonitrile and cyanomethyltrimesitylphosphonium iodide and the relative acidities of XCH2CN (X = Ph3P+, Ph3As+, Mes3P+, or PhSO2)versus acetic acid in acetonitrile (1981)

Contrary to a previous report, PhSO2CH2CN has been shown to exhibit a one-electron reduction (two-electron reductive cleavage followed by deprotonation of PhSO2CH2CN by –CH2CN). Mes3PH2CN I– behaves similarly. The relative acidities of XCH2CN (X = Ph3P+, Ph3As+, Mes3P+, or PhSO2)versus acetic acid in acetonitrile has been studied both voltammetrically and spectrophotometrically. Ph3PH2CN is a stronger acid than CH3CO2H; Ph3AsCH2CN, Mes3PH2CN, and PhSO2CH2CN are weaker acids than CH3CO2H. PhSO2CH2CN and Mes3-PCH2CN I– have been used in an electroanalytical method for studying the addition of –CH2CN to various electrophiles.
High-rate space-time codes motivated by SU[3] (2004)

Fully-diverse constellations, i.e., a set of unitary matrices whose pairwise differences are nonsingular, are useful in multiantenna communications especially in multiantenna differential modulation, since they have good pairwise error properties. Recently, group theoretic ideas, especially fixed-point-free (fpf) groups, have been used to design fully-diverse constellations of unitary matrices. Here we give systematic methods to design space-time codes which are appropriate for three-transmit-antenna differential modulation. The structures of the codes are motivated by the Lie group SU(3). One of the codes, called the AB code, has a fast decoding algorithm using the complex sphere decoder. The diversity products of the codes can be easily calculated and simulated performances show that the codes are better than the group-based codes (A. Shokrollahi, et al., 2001) especially at high rates and as good as the elaborately-designed nongroup codes (A. Shokrollahi, et al., 2001).
Comparison of virus isolation and various polymerase chain reaction methods in the diagnosis of mucocutaneous herpesvirus infection. (2000)

We compared two polymerase chain reaction (PCR) assays (simple and multiplex) and viral isolation to detect herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) in 15 clinical specimens from 13 patients with mucocutaneous herpetic infections. HSV-1 or VZV DNA was detected in 13 specimens by simple PCRs (HSV-1 or VZV PCR) and in 12 specimens by multiplex PCR. On the other hand, viral isolation was positive for 9 specimens only. The PCR protocols used in this study are not only more sensitive and faster than the traditional viral isolation and conventional PCR protocols but also can distinguish rapidly HSV-1 from VZV. We propose the PCRs described here for rapid and precise identification of etiological agents of mucocutaneous herpetic infections.
A 6-Week Double-Blind Comparison of Amlodipine and Placebo in Patients with Stable Exertional Angina Pectoris Receiving Concomitant β-Blocker Therapy (1991)

This study was a multicenter, double-blind comparison of the antianginal efficacy and safety of amlodipine and placebo as adjunctive therapy with constant recommended maintenance doses of beta-blockers. Patients with stable exertional angina pectoris were randomized to placebo or amlodipine at a starting dose of 5 mg once daily. The amlodipine dose was adjusted to 10 mg daily after 2 weeks if angina attacks were not abolished. Antianginal efficacy was assessed throughout the study with angina diaries, investigators' and patients' global evaluations, and with bicycle exercise tests during a placebo run-in period (baseline) and after 2 and 6 weeks of double-blind treatment. On baseline-final analysis, the exercise time to angina onset increased by 13% with amlodipine compared to 6% with placebo (p < 0.05). The total exercise time increased by 11% on amlodipine compared with 2% on placebo, though this difference did not reach statistical significance. Angina attack frequency and nitroglycerin consumption were both reduced by adding amlodipine to beta-blocker treatment. Amlodipine in combination with beta-blocker therapy was well tolerated, with a low incidence of side effects and laboratory test abnormalities. The study showed clearly that addition of amlodipine to beta-blocker therapy in patients with stable angina pectoris was well tolerated and gave improved antianginal efficacy.