gebhart/patrepeval huggingface dataset:
Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor. (1991)

The initiation of mRNA translation is regulated by the reversible phosphorylation of several initiation factors. We report here that tumor necrosis factor-alpha (TNF) rapidly stimulates phosphorylation of one such factor, an mRNA cap binding protein, in several cell types which are important in vitro models of TNF action. This protein has been purified, sequenced, and identified as the proto-oncogene product eukaryotic initiation factor 4E. These data show that phosphorylation of a key component of the cellular translational machinery is a common early event in the various actions of TNF in diverse cell types.
Integrating Immigrants: The Impact of Restructuring Active Labor Market Programs (2016)

We examine the impact of restructuring active labor market programs for unemployed immigrants in Finland. Exploiting a discontinuity in the phase-in rules of the reform, we find that it increased compliers’ cumulative earnings by 47% over a 10-year follow-up period. We attribute these improvements to a more efficient use of existing resources. The reform did not affect total days in training, but it did modify the content toward training specifically designed for immigrants.
A general strategy for interactive decision-making in robotic platforms (2011)

This work presents an intergated strategy for planning and learning suitable to execute tasks with robotic platforms without any previous task specification. The approach rapidly learns planning operators from few action experiences using a competitive strategy where many alternatives of cause-effect explanations are evaluated in parallel, and the most successful ones are used to generate the operators. The system operates without task interruption by integrating in the planning-learning loop a human teacher that supports the planner in making decisions. All the mechanisms are integrated and synchronized in the robot using a general decision-making framework.
Pathobiology of pulmonary arterial hypertension: understanding the roads less travelled (2017)

The pathobiology of pulmonary arterial hypertension (PAH) is complex and incompletely understood. Although three pathogenic pathways have been relatively well characterised, it is widely accepted that dysfunction in a multitude of other cellular processes is likely to play a critical role in driving the development of PAH. Currently available therapies, which all target one of the three well-characterised pathways, provide significant benefits for patients; however, PAH remains a progressive and ultimately fatal disease. The development of drugs to target alternative pathogenic pathways is, therefore, an attractive proposition and one that may complement existing treatment regimens to improve outcomes for patients. Considerable research has been undertaken to identify the role of the less well-understood pathways and in this review we will highlight some of the key discoveries and the potential for utility as therapeutic targets.
Role of Serine‐19 Phosphorylation in Regulating Tyrosine Hydroxylase Studied with Site‐ and Phosphospecific Antibodies and Site‐Directed Mutagenesis (1998)

The effects of depolarization by elevated potassium concentrations were studied in PC12 cells and in stably transfected AtT-20 cells expressing wild-type or [Leu19]-recombinant tyrosine hydroxylase (rTH). Changes in the phosphorylation states of Ser19 and Ser40 in tyrosine hydroxylase (TH) were determined immunochemically using antibodies specific for the phosphorylated state of each site and compared with changes in TH activity in PC12 cell lysates and with changes in L-DOPA biosynthesis rates in intact AtT-20 cells. Treatment of either PC12 cells or AtT-20 cells expressing wild-type rTH with elevated potassium produced a transient increase in the phosphorylation state of Ser19 (up to 0.7 mol of phosphate/mol of subunit) in concert with a more gradual and sustained increase in Ser40 phosphorylation. Elevated potassium treatment also increased TH activity in PC12 cell lysates, but these increases paralleled the temporal course of Ser40, as opposed to Ser19, phosphorylation. Similarly, increases in DOPA accumulation produced by elevated potassium in AtT-20 cells expressing wild-type rTH paralleled the increases in the phosphorylation state of Ser40 but not Ser19. Moreover, elevated potassium produced comparable increases in DOPA accumulation in AtT-20 cells expressing rTH in which Ser19 phosphorylation had been eliminated (by substitution of Leu for Ser19). Thus, depolarization-induced increases in the stoichiometry of Ser19 phosphorylation do not appear to influence directly the activity of TH in situ.
High‐Sensitivity Floating‐Gate Phototransistors Based on WS<sub>2</sub> and MoS<sub>2</sub> (2016)

In recent years, 2D layered materials have been considered as promising photon absorption channel media for next‐generation phototransistors due to their atomic thickness, easily tailored single‐crystal van der Waals heterostructures, ultrafast optoelectronic characteristics, and broadband photon absorption. However, the photosensitivity obtained from such devices, even under a large bias voltage, is still unsatisfactory until now. In this paper, high‐sensitivity phototransistors based on WS 2 and MoS 2 are proposed, designed, and fabricated with gold nanoparticles (AuNPs) embedded in the gate dielectric. These AuNPs, located between the tunneling and blocking dielectric, are found to enable efficient electron trapping in order to strongly suppress dark current. Ultralow dark current (10 −11 A), high photoresponsivity (1090 A W −1 ), and high detectivity (3.5 × 10 11 Jones) are obtained for the WS 2 devices under a low source/drain and a zero gate voltage at a wavelength of 520 nm. These results demonstrate that the floating‐gate memory structure is an effective configuration to achieve high‐performance 2D electronic/optoelectronic devices.
Uppsala Underdogs - A Robot Soccer Project (2006)

Abstract. In this paper, we describe the four-legged soccer team Uppsala Underdogs developed by a group of 4th year computer science students at Uppsala University during the fall of 2004. The project is based on the experience from two similar previous projects. This year the emphasis of the project has been on distribution of data and on support for evaluation and reconfiguration of strategies. To support data distribution, a middleware has been developed, which implements a replication algorithm and provides a clean interface for the other software modules (or behaviors). To enable easy reconfiguration of strategies, an automatabased graphical description language has been developed, which can be compiled into code that uses the database and the lower level modules, such as tactics and positioning, to make decisions and control the robot. In addition, a graphical simulator has been developed in which the strategies can be evaluated. 1
[Modification of drug release with application of pharmaceutical technological methods]. (1999)

Pharmaceutical technological methods, which enable the development of controlled release, prolonged action solid oral dosage forms, are of great importance. The purpose of our study was to apply these methods and evaluate the prepared samples. The first type of the samples were individually coated separated particles, prepared by mixing with lubricant to built up a lubricant film layer on the surface of the drug crystals. The next group of the samples were separately coated particles--wall material was wax--prepared using the following two technologies: fluidisation atomisation process and hot-melt coating. The third group of the samples was the matrix type, where the core material was mixed into the molten mass of the thermosoftening natural coating material or into some synthetic polymer film material. In some cases several surface active agents were added to the molten mixture to achieve a modification in the drug release process and the examined parameters of the samples. For the comparative evaluation of the prepared dosage forms drug release determination and kinetical analysis of the process were maintainly used. The surface morphology was examined on the base of scanning electronmicroscopic and optical microscopic studies. Among the physical and physico-chemical studies particle size analysis was carried out and dynamic contact angles of the solid samples as well as the surface tension decreasing effect was measured to determine the modifying properties of surface active excipients. To sum up, our results demonstrate that the economical and environmentally acceptable melt coating technology was justified as applicable advantageously in a large number of cases for the development of controlled release devices of highly watersoluble drug, even the medical substance is an organic compound having adjustable thermostability.
Anomalous Origin of the Right Coronary Artery From the Pulmonary Artery: Unusual Presentation in an Adult (2012)

We report an anomalous right coronary artery origin from the pulmonary artery presenting in an adult patient.
Section 3 - Issues in contextual missiology. Unshackling the ghosts of the past: Reflecting on the truth and reconciliation process in South Africa (2002)

It has been a joy and a privilege to know Willem Saayman and to work with him in many ways and in different ventures over the years. His insights and erudition, his leadership and courage - sometimes in the face of severe criticism and opposition - his ecumenical spirit, his friendship and loyalty, his sense of fun, and above all his undoubted Christian commitment continue to be as source of inspiration. Because of his intense interest in the work of the Truth and Reconciliation Commission - indeed because of his efforts to help prepare the way, as well as drafting the mandate, for the TRC - I want to submit the following reflections on the work of the TRC and on the unfinished business of reconciliation in South Africa.
Développement et intégration de capteurs acoustiques pour la détection de polluants en milieu aquatique (2016)

International audience
Ancient Host–Pathogen Associations Maintained by Specificity of Chemotaxis and Antibiosis (2006)

Switching by parasites to novel hosts has profound effects on ecological and evolutionary disease dynamics. Switching requires that parasites are able to establish contact with novel hosts and to overcome host defenses. For most host-parasite associations, it is unclear as to what specific mechanisms prevent infection of novel hosts. Here, we show that parasitic fungal species in the genus Escovopsis, which attack and consume the fungi cultivated by fungus-growing ants, are attracted to their hosts via chemotaxis. This response is host-specific: Escovopsis spp. grow towards their natural host cultivars more rapidly than towards other closely related fungi. Moreover, the cultivated fungi secrete compounds that can suppress Escovopsis growth. These antibiotic defenses are likewise specific: in most interactions, cultivars can inhibit growth of Escovopsis spp. not known to infect them in nature but cannot inhibit isolates of their naturally infecting pathogens. Cases in which cultivars are susceptible to novel Escovopsis are limited to a narrow set of host-parasite strain combinations. Targeted chemotactic and antibiotic responses therefore explain why Escovopsis pathogens do not readily switch to novel hosts, consequently constraining long-term dynamics of host-parasite coevolution within this ancient association.
Quantum Efficiency Analysis of Highly Doped Areas for Selective Emitter Solar Cells (2011)

The increase of solar cell efficiency via the implementation of a selective emitter in crystalline silicon solar cells is currently under research and partly in transition into production. The choice of the doping profile underneath the contacts can have significant impact on cell efficiency. In this work, the quantum efficiency of highly doped areas and its impact on the short circuit current are investigated. The aim of this work is to asses the influence of highly doped illuminated areas, which can possibly diminish the gain of the selective emitter structure regarding JSC. Areas of high doping are created by the technique of laser induced diffusion. The doping profile is varied by adjusting the laser pulse energy. The IV characteristics and spectral response of finished solar cells are measured. The internal quantum efficiency is analyzed using a model proposed by Fischer. Deeper diffused profiles are found to have larger dead layers and a linear correlation between the dead layer thickness and the resultant short circuit current is observed. The impact on solar cells with selective emitter is discussed.
Cyclic Sulfones. III.<sup>1,2</sup> Methylation of 2,5-Diphenyl-3,4-dihydroxythiophene-1-dioxide with Methyl Sulfate and Diazomethane (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic Sulfones. III.1,2 Methylation of 2,5-Diphenyl-3,4-dihydroxythiophene-1-dioxide with Methyl Sulfate and DiazomethaneC. G. Overberger and John M. HoytCite this: J. Am. Chem. Soc. 1951, 73, 7, 3305–3308Publication Date (Print):July 1, 1951Publication History Published online1 May 2002Published inissue 1 July 1951https://pubs.acs.org/doi/10.1021/ja01151a092https://doi.org/10.1021/ja01151a092research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis, Structure, and Characterization of N-Ligated Tungsten Selenide Cluster Complexes W6Se8L6 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, Structure, and Characterization of N-Ligated Tungsten Selenide Cluster Complexes W6Se8L6Xiaobing Xie and Robert E. McCarleyCite this: Inorg. Chem. 1995, 34, 24, 6124–6129Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/ic00128a025https://doi.org/10.1021/ic00128a025research-articleACS PublicationsRequest reuse permissionsArticle Views323Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Proteins: the hard sphere, structure and energetics (1990)

The Ramachandran map was derived by treating atoms as hard spheres and restricting allowed conformations so as to avoid steric overlap between non-bonded atoms. The high packing density characteristic of most solids and reflected in individual protein molecules can be anticipated in terms of hard sphere atoms. The constraints of high packing density and avoidance of steric overlap have been used to develop algorithms which attempt to predict sets of sequences consistent with a given protein main-chain architecture. However hard sphere models cannot predict the energetics of specific interactions within the protein-aqueous solvent system. Accurate and detailed measurements of such interactions coupled with high resolution structural information are essential in understanding the relationship between protein sequence and structure. We describe some recent results of such studies in the ribonuclease-S system.
Characterization of an antiviral agent from primary murine fibroblast cultures: murine tissue culture CVI. (1988)

We have previously described a class of virus inhibitors which are produced spontaneously by many types of cells in culture and present in a number of physiological fluids. These inhibitors are differentiated from all other known naturally occurring antiviral substances in regard to their (i) lack of species specificity, (ii) broad antiviral activity (iii) absence of high affinity binding by the inhibitor to the virus, (iv) mechanism of the action of the inhibitor is through inhibition of viral attachment, and (v) extreme thermal stability. In this report, we show that this class of inhibitors can be divided into two distinct subclasses. The first category includes the inhibitor spontaneously produced by cells in culture, originally described as contact-blocking viral inhibitor (CVI), and has a polypeptide component associated with its antiviral activity. The second category includes the inhibitors detected in body fluids and tissue extracts and has no essential peptide structure. Further characterization of CVI with respect to molecular size and stability to heat and a number of chemical reagents and enzymes indicate that the antiviral activity of CVI is associated with a large molecule (90s or approximately 4 million daltons), is stable at 100(8)C, and is resistant to the action of RNase, DNase, sulfhydral reagents, protein denaturants, and extraction by organic solvents.
Development of a practical power transmission line inspection robot based on a novel line walking mechanism (2010)

A mobile robot based on novel line-walking mechanism is proposed for inspecting power transmission lines. The novel mechanism enables the centroid of the robot to concentrate on the hip joint to minimize the drive torque of the hip joint and keep the robot stable when only one leg is hung on line. After reviewing of the line-walking mechanism, power line inspection robot is described in detail. The pose adjustment analysis is carried out to make sure that the robot will keep in stable state when rolling on the power transmission line which forms a catenary curve. The obstacle-navigation cycle of the designed inspection robot is composed of a single-support phase and a double-support phase. The centroid of the robot will be adjusted to shift to the other leg to start a new single-support phase. The feasibility of this concept is then confirmed by performing experiments with a simulated line environment.
A second DNA methyltransferase repair enzyme in Escherichia coli. (1988)

The Escherichia coli ada-alkB operon encodes a 39-kDa protein (Ada) that is a DNA-repair methyltransferase and a 27-kDa protein (AlkB) of unknown function. By DNA blot hybridization analysis we show that the alkylation-sensitive E. coli mutant BS23 [Sedgwick, B. & Lindahl, T. (1982) J. Mol. Biol. 154, 169-175] is a deletion mutant lacking the entire ada-alkB operon. Despite the absence of the ada gene and its product, the cells contain detectable levels of a DNA-repair methyltransferase activity. We conclude that the methyltransferase in BS23 cells is the product of a gene other than ada. A similar activity was detected in extracts of an ada-10::Tn10 insertion mutant of E. coli AB1157. This DNA methyltransferase has a molecular mass of about 19 kDa and transfers the methyl groups from O6-methylguanine and O4-methylthymine in DNA, but not those from methyl phosphotriester lesions. This enzyme was not induced by low doses of alkylating agent and is expressed at low levels in ada+ and a number of ada- E. coli strains.
Biochemical and immunological analyses of cytoskeletal domains of neurons. (1986)

We have used cultured sympathetic neurons to identify microtubule proteins (tubulin and microtubule-associated proteins [MAPs]) and neurofilament (NF) proteins in pure preparations of axons and also to examine the distribution of these proteins between axons and cell bodies + dendrites. Pieces of sympathetic ganglia containing thousands of neurons were plated onto culture dishes and allowed to extend neurites. Dendrites remained confined to the ganglionic explant or cell body mass (CBM), while axons extended away from the CBM for several millimeters. Axons were separated from cell bodies and dendrites by dissecting the CBM away from cultures, and the resulting axonal and CBM preparations were analyzed using biochemical, immunoblotting, and immunoprecipitation methods. Cultures were used after 17 d in vitro, when 40-60% of total protein was in the axons. The 68,000-mol-wt NF subunit is present in both axons and CBM in roughly equal amounts. The 145,000- and 200,000-mol-wt NF subunits each consist of several variants which differ in phosphorylation state; poorly and nonphosphorylated species are present only in the CBM, whereas more heavily phosphorylated forms are present in axons and, to a lesser extent, the CBM. One 145,000-mol-wt NF variant was axon specific. Tubulin is roughly equally distributed between CBM and axon-like neurites of explant cultures. MAP-1a, MAP-1b, MAP-3, and the 60,000-mol-wt MAP are also present in the CBM and axon-like neurites and show distribution patterns similar to that of tubulin. In contrast, MAP-2 was detected only in the CBM, while tau and the 210,000-mol-wt MAP were greatly enriched in axons compared to the CBM. In immunostaining analyses, MAP-2 localized to cell bodies and dendrite-like neurites, but not to axon-like neurites, whereas antibodies to tubulin and MAP-1b localized to all regions of the neurons. The regional differences in composition of the neuronal cytoskeleton presumably generate corresponding differences in its structure, which may, in turn, contribute to the morphological differences between axons and dendrites.