gebhart/patrepeval huggingface dataset:
Compression of DNA sequence reads in FASTQ format (2011)

DSRC is freely available at http:/sun.aei.polsl.pl/dsrc.
Nextstep operating system software : 日本語版 (1993)

第１章 Ｍａｃｈの概念 第２章 Ｍａｃｈメッセージの使用法 第３章 ローダブルカーネルサーバの使用法 第４章 Ｍａｃｈ関数 第５章 ローダブルカーネルサーバの概要 第６章 ローダブルカーネルサーバの設計 第７章 ＮｅＸＴｂｕｓデバイスドライバ 第８章 ネットワークモジュール 第９章 ローダブルカーネルサーバの構築、ロード、デバッグ法 第１０章 カーネルのサポートする関数 付録（ローダブルカーネルサーバのユーティリティ；ＲＯＭモニタとＮＭＩミニモニタ；カーネルサポート関数の要約）
Single‐Crystal Diffraction Patterns from Vitreous Carbon (1974)

In contrast to the broad X‐ray diffraction maxima typical of vitreous materials, electron diffraction studies revealed many regions that give single‐crystal patterns. Although some of the patterns are those of graphite, as expected, many that were obtained corresponded to other carbon crystal forms, e.g. chaoite and carbon VI. In addition, ring patterns of lonsdaleite and diamond were found, and patterns that do not correspond to any known carbon allotrope were obtained.
Interactions between Filamin A and MMP-9 Regulate Proliferation and Invasion in Renal Cell Carcinoma (2014)

This study aimed to analyze the expression, clinical significance of filamin A (FLNA) in renal cell carcinoma (RCC) and biological effects in a cell line by regulating FLNA expression. Immunohistochemistry and Western blotting were used to analyze FLNA protein expression in 70 cases of RCC and normal tissues to study the relationship with clinical factors. FLNA lentiviral and empty vectors were transfected into RCC to study the influence of up-regulated expression of FLNA. FLNA siRNA was transiently transfected into ACHN kidney carcinoma cells by a liposome-mediated method and protein was detected by Western blotting. The level of expression was found to be significantly lower in RCC than normal tissues (p<0.05). No correlation was noted with gender, age, tumor size or pathological types (p>0.05), but links with lymph node metastasis, clinic stage and histological grade were noted (p<0.05). Loss of FLNA expression correlated significantly with poor overall survival time by Kaplan-Meier analysis (p<0.05). Results for biological function showed that ACHN cells transfected with FLNA had a lower survival fraction, significant decrease in migration and invasion, higher cell apoptosis, higher percentage of the G0/G1 phases, and lower MMP-9 protein expression compared with ACHN cells untransfected with FLNA (p<0.05). However, renal 786-0 cells transfected with FLNA siRNA had a higher survival fraction, significant increase in migration and invasion, and higher MMP-9 protein expression compared (p<0.05). In conclusion, FLNA expression was decreased in RCC and correlated significantly with lymph node metastasis, clinic stage, histological grade and poor overall survival, suggesting that FLNA may play important roles as a a tumor suppressor in RCC by promoting degradation of MMP-9.
Computational siRNA Design Considering Alternative Splicing (2010)

RNA interference (RNAi) with small interfering RNA (siRNA) has become a powerful tool in functional and medical genomic research through directed post-transcriptional gene silencing. In order to apply RNAi technique to eukaryotic organisms, where frequent alternative splicing results in diversification of mRNAs and finally of proteins, we need spliced mRNA isoform silencing to study the function of individual proteins. AsiDesigner is a web-based siRNA design software system, which provides siRNA design capability to account for alternative splicing in mRNA level gene silencing. It provides numerous novel functions, including designing common siRNAs for the silencing of more than two mRNAs simultaneously, a scoring scheme to evaluate the performance of designed siRNAs by adopting state-of-the-art design factors, stepwise off-target searching with BLAST and FASTA algorithms, as well as checking the folding secondary structure energy of siRNAs. To do this, we developed a novel algorithm to evaluate the common target region where siRNAs can be designed to knockdown a specific mRNA isoform or more than two mRNA isoforms from a target gene simultaneously. The developed algorithm and the AsiDesigner were tested and validated as being very effective throughout widely performed gene silencing experiments. It is expected that AsiDesigner will play an important role in functional genomics, drug discovery, and other molecular biological research. AsiDesigner is freely accessible at http://sysbio.kribb.re.kr/AsiDesigner .
Global positioning systems data for performance evaluation of HOV and GP lanes on I-66 and I-395/I-95 (2006)

In this study an empirical analysis is conducted for assessing the performance of high occupancy vehicle (HOV) lanes using Global Positioning System (GPS). Second by second speed, time, and location data were obtained from GPS equipped probe vehicles on HOV lanes with exclusive right of way as well as on HOV lanes that share the right of way with general purpose (GP) lanes. Peak-hour operations of HOV facilities on I-66 and I-395/I-95 corridors in the Washington DC area were used as test beds. Parameters for the performance measures such as travel time, mean journey speed, delay, proportion of stopped time and congestion index were developed and compared for HOV and GP lanes. The data were also used to identify location and the extent of congestion along the study routes. The results of the analysis showed travel times saving, higher journey speeds, less delay, and lower congestion incurred by the probe vehicles on the HOV lanes as compared to the probe vehicles traveling simultaneously on non-HOV lanes
Transient Receptor Potential Ion Channels and Animal Sensation: Lessons from Drosophila Functional Research (2004)

Ion channels of the transient receptor potential (TRP) superfamily are non-selective cationic channels with six transmembrane domains. The TRP channel made its first debut as a light-gated Ca2+ channel in Drosophila. Recently, research on animal sensation in Drosophila disclosed other members of the TRP family that are required for touch sensation and hearing as well as the sensation of painful stimuli.
Maximum Bite Force Analysis in Different Age Groups (2014)

Introduction Maximum bite force (MBF) is the maximum force performed by the subject on the fragmentation of food, directly related with the mastication and determined by many factors. Objective Analyze the MBF of subjects according to age groups. Methods One hundred individuals from the city of São Paulo were equally divided according to age groups and gender. Each individual submitted to a myotherapy evaluation composed of anthropometric measurements of height and weight to obtain body mass index (BMI), using a tape and a digital scale (Magna, G-life, São Paulo), and a dental condition and maximum bite force evaluation, using a digital dynamometer model DDK/M (Kratos, São Paulo, Brazil), on Newton scale. The dental and bite force evaluations were monitored by a professional from the area. Analysis of variance was used with MBF as a dependent variable, age group and gender as random factors, and BMI as a control variable. Results Till the end of adolescence, it was possible to observe a decrease in MBF in both sexes, with the male force greater than the female force. In young adults, the female force became greater the males, then decreased in adulthood. There was no correlation between MBF and BMI. Conclusion There are MBF variations that characterizes the human development stages, according to age groups.
A modified sub-optimum adaptive bit and power allocation algorithm in wideband OFDM system (2004)

OFDM and adaptive transmission are two most promising technique for next generation high data rate mobile communication systems. In this paper, we combine the two techniques and propose a simple and computational efficient adaptive bit and power allocation algorithm for broadband OFDM system. In the algorithm, first the bit and corresponding power are allocated to each sub-carrier according to channel condition, water filling theory and QoS requirement of the user, then the residual power is allocated to the sub-carriers which can use them most efficiently. In this way, this algorithm is efficient while calculation is less complex. Simulation results show the advantages of the proposed algorithm over those of equal bit loading algorithm and original SNR based adaptive allocation method.
Influence of UW solution on in vitro platelet aggregability (1996)

Abstract Bleeding problems in or-thotopic liver transplantation (OLT), starting immediately after reperfusion of the graft, are complicating the outcome of transplantation. Platelets may be involved in this situation, but there is still a lack of information about the influence of UW solution on platelet function. We evaluated the effect of UW solution on in vitro platelet aggreg ability in healthy volunteers using whole blood electrical aggregometry and concluded, that UW solution causes impaired platelet aggregabil ity and may contribute to bleeding problems during OLT. The mechanism of impairment remains un clear, since central pathways as well as membrane receptors seem to be involved. Furthermore. our data support the necessity of extended flushing of the liver graft after re perfusion.
Binder effectiveness for beads with high drug levels (1991)

Previous reports from these laboratories showed that microcrystalline cellulose (AvicelR MCC, PH-101) formulations with low and medium drug levels (10 and 50%) produced very uniform beads whereas formulations containing MCC with high drug levels (80%) were difficult to process without special treatment or required the incorporation of alternate excipients. In this study, several binders, at a 2% level, specifically: Carbomer (CarbopolR 934-P), Sodium carboxymethylcellulose (CMC 7MF), Hydroxypropylcellulose (KlucelR HXF), Methylcellulose (MethocelR K-15). Povidone, USP (PVP K29-32) and Pregelatinized starch NF (Starch 1500R), were evaluated to determine whether they might impart advantages in processing and whether any differences in dissolution behavior would result. Spheres containing 80% anhydrous theophylline, the binders and MCC were manufactured by the extrusion/marumerization technique. In general, beads containing high drug levels produced with these binders are suitable for further processing (coating). Processing ease, bead shape, and bead hardness (friability) varied with the choice of binder. Beads with carbomer, hydroxypropylcellulose, and methylcellulose remained intact during dissolution testing; beads with starch, carboxymethylcellulose, PVP, and the control did not.
An Ellipsoidal Representation of Human Hand Anthropometry (1991)

The goal of this study was to collect anthropometric data that describe the geometry of the surface of the hand and to model this anthropometry as a function of gross external hand measurements. The depth and breadth of each segment of the hand were measured at points that were spaced at approximately equal distances between the joints of the hand. Linear models using hand breadth as the independent variable explained from 12% to 47% of the variation in segment breadths and from 6% to 74% in segment depths. Ellipsoids are used in biomechanical models as an efficient mathematical description of the shape of kinematic segments for use in the determination of contact with other objects. Therefore the primary objectives of this study were to approximate the semiaxis dimensions for these hand segment contact bodies using a linear model of the gross anthropometry and to evaluate the accuracy with which ellipsoids describe the geometry of the hand segments. Graphical comparisons showed that differences between the ellipsoidal approximations and the breadth and depth measurements were largest near the joints. Data collected in this study could be used to create a set of overlapping ellipsoids that would provide a more accurate representation of hand geometry, and this representation could be adapted to biomechanical models that use ellipsoids to define segment geometry.
A Primary Care Intervention for Weight Loss: Results of a Randomized Controlled Pilot Study (2009)

Most primary care providers (PCPs), constrained by time and resources, cannot provide intensive behavioral counseling for obesity. This study evaluated the effect of using medical assistants (MAs) as weight loss counselors. The study was a randomized controlled trial conducted in two primary care offices at an academic medical center. Patients (n = 50) had a BMI of 27-50 kg/m(2) and no contraindications to weight loss. They were randomized to quarterly PCP visits and weight loss materials (Control group) or to the same approach combined with eight visits with a MA over 6 months (Brief Counseling). Outcomes included change in weight and cardiovascular risk factors (glucose, lipids, blood pressure, and waist circumference). Patients in the Brief Counseling and Control groups lost 4.4 +/- 0.6 kg (5.1 +/- 0.7% of initial weight) and 0.9 +/- 0.6 kg (1.0 +/- 0.7%), respectively, at month 6 (P < 0.001). There were no significant differences between groups for changes in cardiovascular risk factors. Brief Counseling patients regained weight between month 6 and month 12, when MA visits were discontinued. Attrition was 10% after 6 months and 6% after 12 months. Brief Counseling by MAs induced significant weight loss during 6 months. Office-based obesity treatment should be tested in larger trials and should include weight loss maintenance counseling.
General Aviation Aircraft Flight Operations Quality Assurance: Overcoming the Obstacles (2007)

This describes the initiative to introduce a capable yet affordable Flight Operations Quality Assurance (FOQA) program into the general aviation industry. A brief overview of the FOQA concept is given along with a historical perspective to the evolution of such programs. Initial development of a FOQA program for general aviation by the Center for Sensors and Sensor Systems at Saint Louis University is introduced herein. A brief discussion of the obstacles in developing such a system is presented, as well as strategies for overcoming these obstacles. The system consists mainly of a quick access recorder (QAR) that is conceived to be a stand-alone, non-intrusive system that collects parametric flight data, a preprocessor system to analyze initial data sets and validate their use, and post-processor software used in the analysis of available flight parameters. The program concepts are presented for initial determination of the needs and possibilities, and examples are presented along with flight data collected in the University's fleet of aircraft.
Bilateral facet to spinous process fusion (1983)

A variety of options exist for the treatment of fracture/dislocation of the cervical spine, including prolonged traction immobilization, immobilization in an external device, and open surgical fusion. In cases of facet dislocation and flexion/compression injuries, the authors have found that surgical fusion is the most useful. However, in cases of facet fracture or disruption of the posterior neural arch, routine interspinous wiring techniques do not provide adequate rotational stability and may allow postsurgical redislocation before bony fusion. For these cases, a new technique using bilateral facet to spine wire loops has been developed. In the 25 cases reported here, the technique provided excellent stability against anterior horizontal displacements and rotational dislocations despite unilateral or bilateral facet fracture or disruption of the posterior neural arch. (Neurosurgery 13:1-4, 1983)
Ferromagnetism in freestanding MoS2 nanosheets (2013)

Freestanding MoS2 nanosheets with different sizes were prepared through a simple exfoliated method by tuning the ultrasonic time in the organic solvent. Magnetic measurement results reveal the clear room-temperature ferromagnetism for all the MoS2 nanosheets, in contrast to the pristine MoS2 in its bulk form which shows diamagnetism only. Furthermore, results indicate that the saturation magnetizations of the nanosheets increase as the size decreases. Combining the X-ray photoelectron spectroscopy, transmission electron microscopy, and electron spin resonance results, it is suggested that the observed magnetization is related to the presence of edge spins on the edges of the nanosheets. These MoS2 nanosheets may find applications in nanodevices and spintronics by controlling the edge structures.
Anthracyclines Suppress Both NADPH Oxidase- Dependent and -Independent NETosis in Human Neutrophils (2019)

Neutrophil extracellular traps (NETs) are cytotoxic DNA-protein complexes that play positive and negative roles in combating infection, inflammation, organ damage, autoimmunity, sepsis and cancer. However, NETosis regulatory effects of most of the clinically used drugs are not clearly established. Several recent studies highlight the relevance of NETs in promoting both cancer cell death and metastasis. Here, we screened the NETosis regulatory ability of 126 compounds belonging to 39 classes of drugs commonly used for treating cancer, blood cell disorders and other diseases. Our studies show that anthracyclines (e.g., epirubicin, daunorubicin, doxorubicin, and idarubicin) consistently suppress both NADPH oxidase-dependent and -independent types of NETosis in human neutrophils, ex vivo. The intercalating property of anthracycline may be enough to alter the transcription initiation and lead NETosis inhibition. Notably, the inhibitory doses of anthracyclines neither suppress the production of reactive oxygen species that are necessary for antimicrobial functions nor induce apoptotic cell death in neutrophils. Therefore, anthracyclines are a major class of drug that suppresses NETosis. The dexrazoxane, a cardioprotective agent, used for limiting the side effects of anthracyclines, neither affect NETosis nor alter the ability of anthracyclines to suppress NETosis. Hence, at correct doses, anthracyclines together with dexrazoxane could be considered as a therapeutic candidate drug for suppressing unwanted NETosis in NET-related diseases.
A hybrid dynamic time warping-deep neural network architecture for unsupervised acoustic modeling (2015)

We report on an architecture for the unsupervised discovery of talker-invariant subword embeddings. It is made out of two components: a dynamic-time warping based spoken term discovery (STD) system and a Siamese deep neural network (DNN). The STD system clusters word-sized repeated fragments in the acoustic streams while the DNN is trained to minimize the distance between time aligned frames of tokens of the same cluster, and maximize the distance between tokens of different clusters. We use additional side information regarding the average duration of phonemic units, as well as talker identity tags. For evaluation we use the datasets and metrics of the Zero Resource Speech Challenge. The model shows improvement over the baseline in subword unit modeling.
Quantitative Analysis of Individual Sugars and Acids in Orange Juices by Near-Infrared Spectroscopy of Dry Extract (1996)

The combination of near-infrared spectroscopy (near-IR) and multivariate calibration for determination of glucose, fructose, sucrose, and citric and malic acids in orange juices was investigated. The concentrations of these components analyzed by enzymatic assays were considered as references relative to near-IR spectroscopy. Dry extract spectra of 218 orange juice samples were recorded in transmission mode between 1100 and 2500 nm. The original near-IR spectral data could be improved by mathematical pretreatments such as derivative transformations or multiplicative signal correction. Stepwise multiple linear regression (SMLR) and partial least-squares regression (PLSR) were used to create calibration models relating chemical reference values to spectral data. The prediction ability of calibration models is acceptable in comparison with the reference methods. The calibration and validation results provided by PLS-1 calibration models are slightly better than those obtained with SMLR calibration models. Keywords: Sugars; acids; orange juices; near-infrared spectroscopy; multivariate calibration
The Waltham book of companion animal nutrition- a review (1995)

Writing a text on nutrition that is both easy to read and informative is difficult. The subject has the potential to produce anesthesia in even the most conscientious reader. To understand the full scope of nutrition, it is necessary to review basic gastrointestinal physiology and metabolism, as well as the function of all the nutrients.
Microstructure and Corrosion Properties of Mg-Zn-Ca-Zr Alloy for Biomedical Application (2013)

The microstructuresandcorrosion properties of the as-cast Mg-Zn-Ca-Zralloys were investigated in this study. The results showed that the alloy was mainly composed of -Mg solid solution,Zr particle and the secondary phase of Ca 2 Mg 6 Zn 3 . The grain size of alloy specimens decreased with the increment of Zr content. The corrosion resistances were found to increase from 0.3% to 0.5% and then decrease from 0.5% to 0.7%. The Mg-4Zn-0.5Ca-0.5Zr had the best corrosion resistance in SBF solution.This was attributed to a combination of (1) the uniform and fine microstructure of alloy, (2) continuous distributions of the secondary phases, and (3) a lower volume fraction of Zr particles.
Natural Bioenhancers: An overview (2013)

Bioenhancers are chemical entities which promote and augment the bioavailability of the drugs which are mixed with them and do not exhibit synergistic effect with the drug. The need for bioenhancers arises due to drugs which are poorly available, administered for long periods, toxic and expensive. Bioenhancers can be classified based on their natural origin as well as based on the various mechanisms elicited by them when in combination with drugs to improve their bioavailability. The various bioenhancers available are piperine, garlic, Carum carvi, Cuminum cynimum, lysergol, naringin, quercetin, niaziridin, glycyrrhizin, stevia, cow urine distillate ginger. Out of these, Cuminum cynimum and niaziridin are the potential bioenhancers of future. Therefore, the need of the hour is to carry out extensive research on these bioenhancers so that they could be utilised in the drug formulations
Emerging anxiolytics (2007)

Anxiety disorders are the most common of the psychiatric disorders and are also associated with significant economic costs and impaired work productivity. The first-line pharmacotherapy of pharmatherapy for a number of anxiety disorders comprises selective serotonin re-uptake inhibitors (SSRIs) and serotonin and noradrenaline re-uptake inhibitors (SNRIs). Benzodiazepines are still widely used for the treatment of several anxiety disorders. Although these agents are effective, many patients are treatment-refractory and more effective, better tolerated medications are required. This paper discusses the understandings of mechanisms involved in the anxiety disorders and reviews emerging medications. Mechanisms underlying the use of d-cycloserine, second generation antipsychotics and beta-blockers are particularly exciting.
Who Are Our Future Farm Homemakers (1960)

A young woman's future in our society depends a lot on the man she marries and his choice of a career and location. We found the plans of farm girls less definite than those of farm boys, but there are still some implications.