gebhart/patrepeval huggingface dataset:
The 160 <i>N</i>‐terminal residues of calnexin define a novel region supporting viability in <i>Schizosaccharomyces pombe</i> (2007)

Protein secretion is a complex process that can be modulated by folding factors in the endoplasmic reticulum (ER), such as calnexin, a highly-conserved molecular chaperone involved in quality control. In Schizosaccharomyces pombe, calnexin (Cnx1p) is essential for cell viability. The calnexin/Cnx1p determinants required for viability have been mapped within the last 123 residues of its C-terminus. To better understand the role(s) of calnexin/Cnx1p in secretion, we screened for cnx1 mutants 'super-secreting' cellulase. We identified ss14_cnx1, a mutant secreting 10-fold higher levels of the glycoprotein cellulase than the wild-type strain. While cellulase did not interact with ss14_Cnx1p, the ratio of secreted activity/quantity for this enzyme was not affected, suggesting that the quality control of folding in the ER was adequate in the mutant strain. Surprisingly, the ss14_Cnx1p mutant is composed of the 160 N-terminal amino acids of the mature molecule, thus this mutant defines a novel calnexin/Cnx1p region supporting Sz. pombe viability. Interestingly, like viable mutants spanning the last 52 aa of calnexin/Cnx1p, the 160 N-terminal residues encoded by ss14_cnx1 also forms a complex with the essential BiP chaperone. These results reveal the so far unidentified importance of the N-terminal region of calnexin/Cnx1p.
Group B Streptococcal Disease in Nonpregnant Adults (2001)

Group B streptococcal (GBS) disease in nonpregnant adults is increasing, particularly in elderly persons and those with significant underlying diseases. Diabetes, neurological impairment, and cirrhosis increase risk for invasive GBS disease. Skin, soft-tissue, and osteoarticular infections, pneumonia, and urosepsis are common presentations. Meningitis and endocarditis are less common but associated with serious morbidity and mortality. Disease is frequently nosocomial and may be related to the placement of an iv catheter. Recurrent infection occurs in 4.3% of survivors. Capsular serotypes Ia, III, and V account for the majority of disease in nonpregnant adults. Although group B streptococci are susceptible to penicillin, minimum inhibitory concentrations are 4-fold to 8-fold higher than for group A streptococci. Resistance to erythromycin and clindamycin is increasing. The role of antibodies in protection against GBS disease in nonpregnant adults is unresolved. However, the immunogenicity of GBS vaccines being developed for prevention of neonatal disease should be assessed for adults who are at risk.
Homocysteine alters monocyte-endothelial interaction in vitro. (2003)

Homocysteine alters monocyte-endothelial interaction in vitro, eventually bringing about endothelial damage through release of H(2)O(2). These phenomena are mediated through monocyte surface glycoproteins CD11b/CD18 and CD14. Upregulation of these processes in vivo may contribute to acceleration of atherosclerosis in patients with elevated plasma homocysteine levels.
Airborne tactical information management system in-cockpit mission replanning and rehearsal (ATIMS/ICMRR) (2002)

The United States Navy Program Executive Office for Tactical Aircraft Programs is developing an Airborne Tactical Information Management System (ATIMS) capability under the Space and Naval Warfare Systems Command (SPAWAR-32) Real Time Support for Joint Power Projection Advanced Technology Demonstration (ATD) program. The ATIMS project is leveraging modular processing, advanced display and virtual reality technology to demonstrate a capability that provides enhanced flight situation awareness of engagement parameters, exploitation of information for mission alternative selection and more responsive unit level mission planning and rehearsal. The ATIMS project is focused on developing tactical information management and cockpit automation technology to simultaneously reduce pilot workload, reduce system avionics cost, enhance operational flexibility and increase mission effectiveness for air-to-air or air-to-ground combat operations. In a cooperative effort with the Air Force Avionics Directorate, Wright Laboratory (WL/AART-3), the In-Cockpit Mission Replanning and Rehearsal (ICMRR) program is providing ATIMS concept development, long-term master planning and technology demonstration integration support.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder (1998)

The study indicates that MOCLO may not be helpful in FM patients free from clinically meaningful psychiatric problems.
Complications of guided blind endotracheal intubation (1979)

The complications observed in twelve patients undergoing guided blind nasotracheal intubation are presented. The commonest was minor bleeding, followed by difficulty in hooking the cannula out of the nostril. These complications are minor enough to justify the more frequent use of the technique in patients with intubation problems.
Evaluating the Magnitude of Time-Lapse Effects through 4D Core Tests – Lessons from a North Sea Reservoir (SPE94195) (2005)

SPE 94195 Evaluating the Magnitude of Time-Lapse Effects Through 4D Core Tests: Lessons From a North Sea Reservoir F. Golfetto O. Meazza and A. Sturniolo Eni S.p.A. Copyright 2005 Society of Petroleum Engineers This paper was prepared for presentation at the SPE Europec/EAGE Annual Conference held in Madrid Spain 13-16 June 2005. This paper was selected for presentation by an SPE Program Committee following review of information contained in an abstract submitted by the author(s). Contents of the paper as presented have not been reviewed by the Society of Petroleum Engineers and are subject to correction by the author(s). The
Low Voltage Ride Through of Wind Farms With Cage Generators: STATCOM Versus SVC (2008)

This paper analyzes the extent to which the low voltage ride through (LVRT) capability of wind farms using squirrel cage generators can be enhanced by the use of a STATCOM, compared to the thyristor controlled static var compensator (SVC). The transient stability margin is proposed as the indicator of LVRT capability. A simplified analytical approach based on torque-slip characteristics is first proposed to quantify the effect of the STATCOM and the SVC on the transient stability margin. Results from experiments with a STATCOM and a 7.5 kW induction machine emulating a wind turbine are used to validate the suggested analytical approach. Further verifications based on detailed time-domain simulations are also provided. Calculations, simulations and measurements confirm how the increased STATCOM rating can provide an increased transient stability margin and thus enhanced LVRT capability. Compared to the SVC, the STATCOM gives a larger contribution to the transient margin as indicated by both calculations and simulations. The inaccuracies introduced by neglecting the flux transients in the suggested approach are discussed and found reasonable for an estimation method when considering the simplicity compared to detailed time-domain simulation studies. A method for estimating the required rating of different compensation devices to ensure stability after a fault is suggested based on the same approach.
The Principle of Polysaccharide Gels (2015)

For several decades attention has been directed to natural polysaccharide gels and synthesized polymer gels. The structure-function relationships at molecular level in water of polysaccharides, κ-carrageenan, ι-carrageenan, agarose (agar), and gellan family of polysaccharides (gellan, welan, rhamsan, S-657, deacetylated rhamsan and native gellan gum), which are industrially useful polysaccharides extracted from family of red seaweeds and bacteria, in principle are discussed on the view point of rheological aspects. The polysaccharide molecules (0.1% - 1.0%) play a dominant role in the center of the tetrahedral cavities occupied by water molecules (99.0% - 99.9%), and the arrangement is similar to a tetrahedral structure in a gelation process. The cage and hydrophobic effect play thermal dynamically dominant role in gelation process which gives lowest entropy to electrons of sugar residues. Though the chemical structure of these polysaccharides similar each other, their rheological (gelling) characteristics are quite different. Many investigations about the gelling properties of the polysaccharides have been undertaken to elucidate the structure-function relationship, but no other researchers have established mechanism at the molecular level. There is consistency in our investigations. Thus, the rheological analysis is one of significant methods for understanding the structure-function relationship of polysaccharides in aqueous media. The discussion provides many important information not only in academic field, but also in industrial one, such as food, cosmetic, pharmaceutical, drug delivery and tissue industries, and biotechnology.
Pulse Spectrum Analysis in Primary Hypertension Patients (2006)

Background and Purpose: Arterial pulse diagnosis is noninvasive and it is very popular in traditional Chinese medicine clinics. The aim of this study was to evaluate the possibility of using pulse diagnosis in patients with the primary hypertension. Methods: Noninvasive analyses of radial pulses were taken in primary hypertension patients immediately after their arrival at the physical examination room. They then underwent physical health examinations including measurement of blood pressure and heart rate, EKG, blood test, urine test, x-ray, ultrasound scanning, and recording medical history. We carried out pulse spectrum analysis on 110 patients with possible primary hypertension. We used five criteria for pulse diagnosis of blood pressure abnormalities to test for correlation. These were (1) C1≧2 (in intensity) and C4≦-3 (in intensity) or C4≦-2 (in phase), (2) C0≧4 (in intensity) and C4≦-2 (in intensity), (3) C0≧4 (in intensity) and C3≦-2 (in intensity) and C3≦-2 (in phase), (4) C0≧4 (in intensity) and C3≦-2 (in intensity) and C5≦-3 (in intensity), (5) C3≦-2 (in intensity and phase) and C6≦-2 (in intensity and phase). For the intensity, C1 (liver) every 5% above normal was given one ”+”, every 5% below normal was given one ”-”. For C3 (spleen), C4 (lung), C6 (gallbladder), every 10% above normal was given one ”+”, every 10% below normal was given one ”-”. For the phase, every 10% delay in the traveling speed of the pressure wave was given one ”-”. Results: Only the ”+”, ”N” (N = normal) and ”-” states were considered, while quantities of ”+” ”-” were not monitored. In the pulse analysis, there were 311 (from intensity) × 311 (from phase) = 177, 147 × 177, 147 possible states (3 qualitative states and 11 harmonics). We considered only five criteria for blood pressure abnormalities and the correlation was very high, p＜0.001, Kappa = 0.701. Conclusion: The results strongly suggested that each harmonic of pulse spectrum has physiological and pathological importance in the circulation and it is worth further study.
Lightning Arrester Field Test Equipment and Results (1959)

Lightning arresters play an important role in the protection of power system insulation against damage by surge voltages. Many arresters which have been in service a considerable number of years are still expected to provide this protection even for insulation that may not possess the strength as specified for new apparatus. The results of various methods used in the past to check arrester condition in the field are often questionable. A novel field test method for lightning arresters has therefore been developed. Impulse sparkover and power frequency leakage tests in the field can be carried out, with portable test equipment, on line-type and station-type lightning arresters with single-unit ratings up to 37 kv. Design and operating principles of this equipment are described; the field test results indicate that with the new method it is possible reliably to detect arresters not performing according to requirements.
Mid-infrared frequency comb spanning an octave based on an Er fiber laser and difference-frequency generation (2013)

Summary form only given. We describe a coherent mid-infrared continuum source with 700 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> usable bandwidth, readily tuned within 600-2500 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> (18-75 THz) and thus covering much of the infrared "fingerprint" molecular vibration region [1]. It is based on nonlinear frequency conversion in GaSe using a compact commercial 100-fs-pulsed Er fiber laser system providing two amplified near-infrared beams, one of them broadened by a nonlinear optical fiber. The resulting collimated mid-infrared continuum beam of 1 mW quasi-cw power represents a coherent infrared frequency comb with zero carrier-envelope phase, containing about 500,000 modes that are exact multiples of the pulse repetition rate of 40 MHz. The beam's diffraction-limited performance enables long-distance spectroscopic probing as well as maximal focusability for classical and ultraresolving near-field microscopies. Applications are foreseen also in studies of transient chemical phenomena even at ultrafast pump-probe scale, and in high-resolution gas spectroscopy for e.g. breath analysis.One application area is spectroscopic near-field microscopy where near-field spectra were obtained in exploring polymer fingerprints at 20 nm spatial resolution [2-7]. For the first time, a multitude of resonances between 750 and 1730 cm-1 could be determined with the help of this novel coherent continuum source (Fig. 1).A final positive aspect of mid-infrared dual-comb spectroscopy [5,6] is the ability to record spectra in rapid sequence, thus allowing to follow chemical reactions in real time. Even ultrafast phenomena could be probed with our coherent mid-infrared source. To understand this recall it emits repetitive pulses of sub 100 fs duration which can be systematically delayed o r advanced in respect to a "pump" pulse which could induce specific excitations of a sample.
Osteoarthritis: From Palliation to Prevention (2014)

Osteoarthritis is a leading cause of disability. The traditional focus on late-stage osteoarthritis has not yielded effective disease-modifying treatments. Consequently, current clinical care focuses on palliation until joint replacement is indicated. A symposium format was used to examine emerging strategies that support the transformation of the clinical approach to osteoarthritis from palliation to prevention. Central to this discussion are concepts for diagnosis and treatment of pre-osteoarthritis, meaning joint conditions that increase the risk of accelerated development of osteoarthritis. The presentation of translational and clinical research on three common orthopaedic conditions-anterior cruciate ligament tear, intra-articular fracture, and hip dysplasia-were used to illustrate these ideas. New information regarding the use of novel quantitative magnetic resonance imaging (MRI) in the form of ultrashort echo time enhanced T2* (UTE-T2*) mapping to evaluate the potential for articular cartilage to heal subsurface damage in a mechanically sound environment was presented. These data indicate that improved diagnostics can both identify cartilage at risk and evaluate the effectiveness of early treatment strategies. With use of a new mouse model for intra-articular fracture, it was shown that inflammation correlated to fracture severity and that super-healer mice avoided early posttraumatic osteoarthritis in part through an enhanced ability to dampen inflammation. These findings suggest that there is a role for acute and sustained anti-inflammatory treatment in the prevention of osteoarthritis. For long-term treatment, contemporary gene-therapy approaches may offer an effective means for sustained intra-articular delivery of anti-inflammatory and other bioactive agents to restore joint homeostasis. To illustrate the potential of early treatment to prevent or delay the onset of disabling osteoarthritis, the positive clinical effects on articular cartilage and in long-term clinical follow-up after operative correction of structural abnormalities about the hip highlight the role for targeting mechanical factors in delaying the onset of osteoarthritis. Given that orthopaedic surgeons treat the full spectrum of joint problems, ranging from joint trauma to pre-osteoarthritic conditions and end-stage osteoarthritis, an awareness of the paradigm shift toward the prevention of osteoarthritis is critical to the promotion of improved clinical care and participation in clinical research involving new treatment strategies.
Robust monocular visual odometry using optical flows for mobile robots (2016)

A robust optical flow-based visual odometry method using a single onboard camera is proposed in this paper. To improve the quality of the noisy optical flows, a correction method across multiple frames is developed. Furthermore, the optical flows in the plane at infinity are detected and removed as these optical flows have very low signal to noise ratio for robot translation estimation. Finally, a RANSAC approach for robot ego-motion estimation is proposed. Physical experiments are carried out and the results show that the proposed method is able to estimate the camera trajectory robustly with reasonable accuracy.
The diverse carbenic and cationic chemistry of 3-diazo-2,5-diphenylpyrrole (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe diverse carbenic and cationic chemistry of 3-diazo-2,5-diphenylpyrroleM. Nagarajan and H. ShechterCite this: J. Org. Chem. 1984, 49, 1, 62–74Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/jo00175a012https://doi.org/10.1021/jo00175a012research-articleACS PublicationsRequest reuse permissionsArticle Views431Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantitative Organic Analysis Via Functional Groups (1963)

Describes the methods for identifying and measuring the amounts of organic constituents present in materials--organic compounds either in the pure state or in complex mixtures. Uses the functional groups as the analytical handle for measuring the compounds being studied, and shows interrelationships between methods. This Fourth Edition includes the latest methods and increases the scope of the discussions.
Interleukin‐6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study (2009)

This followup study showed that individuals were more likely to be diagnosed as having RKOA if they had a higher BMI and increased circulating levels of IL-6. These results should stimulate more work on IL-6 as a potential therapeutic target.
Effects of anti-IL-4 receptor monoclonal antibody on<i>in vitro</i>T cell cytokine levels: IL-4 production by T cells from non-atopic donors (1998)

IL-4 is a pleiotropic cytokine which is involved in the development of atopic diseases. Only limited data exist on IL-4 production in humans, and the relative contribution to atopy of either unbalanced IL-4 production, or increased IL-4-responsiveness of target cells, is still unknown. The use of a MoAb to the IL-4 receptor alpha-chain (IL-4Ralpha) enabled us to demonstrate that IL-4 production in vitro is usually underestimated, due to in vitro consumption, even in cultures of purified T cells. When IL-4 consumption was blocked, it became evident that CD80 and CD86 both provide effective costimulatory signals for high IL-4 production. Moreover, we found that even stimulation with a soluble antigen (tetanus toxoid) induces IL-4 production by T cells from healthy non-atopic donors. Both sets of data imply that IL-4 is not required for IL-4 production by memory and/or effector T cells. Our data further show that endogenous IL-4 activity modulates IL-10 and interferon-gamma production by T cells in opposite directions. The use of this receptor-blocking antibody will thus be helpful for in vitro studies on IL-4 regulation. Consumption of IL-4 by different cell types during in vitro cultures might have interfered with previous attempts to quantify IL-4 production by human T cells.
Alzheimer's Disease and the Amyloid Cascade Hypothesis: A Critical Review (2012)

Since 1992, the amyloid cascade hypothesis has played the prominent role in explaining the etiology and pathogenesis of Alzheimer's disease (AD). It proposes that the deposition of β-amyloid (Aβ) is the initial pathological event in AD leading to the formation of senile plaques (SPs) and then to neurofibrillary tangles (NFTs), neuronal cell death, and ultimately dementia. While there is substantial evidence supporting the hypothesis, there are also limitations: (1) SP and NFT may develop independently, and (2) SPs and NFTs may be the products rather than the causes of neurodegeneration in AD. In addition, randomized clinical trials that tested drugs or antibodies targeting components of the amyloid pathway have been inconclusive. This paper provides a critical overview of the evidence for and against the amyloid cascade hypothesis in AD and provides suggestions for future directions.
An asymmetric synthesis of (+)-morphinans in high enantiomeric purity (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn asymmetric synthesis of (+)-morphinans in high enantiomeric purityA. I. Meyers and Thomas R. BaileyCite this: J. Org. Chem. 1986, 51, 6, 872–875Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/jo00356a023https://doi.org/10.1021/jo00356a023research-articleACS PublicationsRequest reuse permissionsArticle Views1033Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts