gebhart/patrepeval huggingface dataset:
A rare case of localised AA-type amyloidosis of the ureter with spheroids of amyloid. (2012)

We present a case of localised AA-type amyloidosis of the ureter with spheroids of amyloid. Localised AA-type amyloidosis of the urogenital tract is uncommon and extremely rare as a cause of ureteric obstruction, with only two such cases described in the literature to date. Most previously described cases at this site are related to primary AL-type amyloidosis. Another interesting finding in this case is the presence of spheroids of amyloid, which to the best of our knowledge, has not been previously reported at this site, and is also unusual at other sites.
Evaluation of Acid Treatment Results for Water-Injector Wells in Saudi Arabia (2006)

Abstract Several acid treatments were conducted in the Ghawar filed to increase the well injectivity and to support the reservoir pressure in this area. Vertical and horizontal wells with an open hole completion in a carbonate reservoir were selected to be a candidate for post acid treatments evaluation study. These wells were stimulated using hydrochloric and emulsified acid with foamed viscoelastic-based water. Viscoelastic-based water system was used to enhance the diversion mechanism and the lifting process for the spent acid following the treatment. In this paper new correlations for acid treatment design were obtained from an extensive study of several case histories that can be used for optimizing future acid treatments design in the Ghawar field. This study was mainly utilized the results from the post acid treatment jobs in terms of HCl acid, emulsified acid and viscoelastic volume correlated with the well's injectivity. Based on the study results, there is a strong relationship between the emulsified acid volumes with the injectivity index for the selected wells.
Low-cost process for fabricating polysilicon transistors (1990)

A process for the fabrication of p-channel polysilicon MOS transistors is described. The process is compatible with the use of low-temperature glass substrates and replaces the use of ion implantation for the source/drain doping with in situ doped polysilicon. MOS transistors made with this process exhibit an on/off current ratio of 2.5*10/sup 5/, a mobility of 16 cm/sup 2//V-s, and a subthreshold slope of 1.3 V/decade.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optical trapping of nanoparticles by full solid-angle focusing (2016)

Optical dipole-traps are used in various scientific fields, including classical optics, quantum optics and biophysics. Here, we propose and implement a dipole-trap for nanoparticles that is based on focusing from the full solid angle with a deep parabolic mirror. The key aspect is the generation of a linear-dipole mode which is predicted to provide a tight trapping potential. We demonstrate the trapping of rod-shaped nanoparticles and validate the trapping frequencies to be on the order of the expected ones. The described realization of an optical trap is applicable for various other kinds of solid-state targets. The obtained results demonstrate the feasibility of optical dipole-traps which simultaneously provide high trap stiffness and allow for efficient interaction of light and matter in free space.
Effect of orthotopic tissue co-implantation on TRAMP C2 and MOVCAR16 tumor growth. (2013)

Growth curves of TRAMPC2 and MOVCAR-16 tumor spheroids expressing H2B-GFP that were implanted directly onto the dorsal skin (sc) or with respective orthotopic donor tissue (EO) (prostate and ovary respectively) and monitored through the dorsal skin window chamber by IVM at the indicated times.
Accurate Calibration of Microscope Magnification Standard (2003)

Journal Article Accurate Calibration of Microscope Magnification Standard Get access JA Kramar, JA Kramar National Institute of Standards and Technology, Gaithersburg, MD 20899-821 Search for other works by this author on: Oxford Academic Google Scholar GW Witzgall, GW Witzgall National Institute of Standards and Technology, Gaithersburg, MD 20899-821 Search for other works by this author on: Oxford Academic Google Scholar VP Scheuerman, VP Scheuerman National Institute of Standards and Technology, Gaithersburg, MD 20899-821 Search for other works by this author on: Oxford Academic Google Scholar MT Postek MT Postek National Institute of Standards and Technology, Gaithersburg, MD 20899-821 Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 9, Issue S02, 1 August 2003, Pages 718–719, https://doi.org/10.1017/S1431927603443596 Published: 01 August 2003
Radial carpal bone fracture in dogs (2001)

In a retrospective study, 11 radial carpal bone (RCB) fractures in nine dogs were studied. Chronic lameness was reported in all dogs. Reduced range of motion and soft-tissue swelling of the carpal joints were clinical signs seen most frequently. Three common fracture patterns were identified: oblique fracture with a large medial fragment, sagittal fracture with a small medial fragment, and comminuted fracture. Radial carpal bone sclerosis and carpal osteoarthritis were identified in all dogs. Pancarpal arthrodesis was used to manage 55% of the RCB fractures in this report. Although RCB fracture is not associated with obvious trauma, the fracture mechanism is unknown.
Free fatty acid metabolism of the human heart at rest (1969)

Myocardial substrate metabolism was studied in 13 subjects at the time of diagnostic cardiac catheterization by means of palmitic acid-(14)C infusion with arterial and coronary sinus sampling. Two subjects were considered free of cardiac pathology and all, with one exception, demonstrated lactate extraction across the portion of heart under study. Data for this single lactate-producing subject were treated separately.The fractional extraction of (14)C-labeled free fatty acids (FFA) (44.4+/-9.5%) was nearly twice that of unlabeled FFA (23.2+/-7.8%) and raised the possibility of release of FFA into the coronary sinus. FFA uptake, based on either the arterial minus coronary sinus concentration difference or the FFA-(14)C fractional extraction, was directly proportional to the arterial FFA concentration. Gas-liquid chromatography failed to demonstrate selective handling of any individual FFA by the heart. Fractional oxidation of FFA was 53.5+/-12.7%, accounting for 53.2+/-14.4% of the heart's oxygen consumption while nonlipid substrates accounted for an additional 30.0+/-17.3%. Determinations of both labeled and unlabeled triglycerides suggested utilization of this substrate by the fasting human heart. Direct measurement of FFA fractional oxidation as well as FFA uptake, exclusive of possible simultaneous FFA release, would appear necessary in studies concerned with human myocardial FFA metabolism.
<title>Methods of formation and nonlinear conversion of Bessel optical vortices</title> (2001)

Linear and nonlinear processes of generation and transformation of optical vortices in crystals were investigated. New universal methods for production of Bessel light beams with optical vortices of the first, second and higher order by means of uniaxial and biaxial crystals were proposed. Light beams with optical vortices of topological charge +/- 1 and +/- 2 are experimentally obtained using KTP and HIO<SUB>3</SUB> (iodic acid) biaxial crystals. We studied type II second harmonic generation by Bessel beams with optical vortices in nonlinear crystals. Results of investigation of the processes of Bessel light vortex order doubling, transfer of vortex to the second harmonic radiation, and annihilation of optical vortices with the opposite signa are presented.
Active Perception in Adversarial Scenarios using Maximum Entropy Deep Reinforcement Learning (2019)

We pose an active perception problem where an autonomous agent actively interacts with a second agent with potentially adversarial behaviors. Given the uncertainty in the intent of the other agent, the objective is to collect further evidence to help discriminate potential threats. The main technical challenges are the partial observability of the agent intent, the adversary modeling, and the corresponding uncertainty modeling. Note that an adversary agent may act to mislead the autonomous agent by using a deceptive strategy that is learned from past experiences. We propose an approach that combines belief space planning, generative adversary modeling, and maximum entropy reinforcement learning to obtain a stochastic belief space policy. By accounting for various adversarial behaviors in the simulation framework and minimizing the predictability of the autonomous agent's action, the resulting policy is more robust to unmodeled adversarial strategies. This improved robustness is empirically shown against an adversary that adapts to and exploits the autonomous agent's policy when compared with a standard Chance-Constraint Partially Observable Markov Decision Process robust approach.
Trinitro-phenylethyl Amines from TNT<sup>1</sup> (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrinitro-phenylethyl Amines from TNT1Herman A. Bruson and George B. ButlerCite this: J. Am. Chem. Soc. 1946, 68, 11, 2348–2350Publication Date (Print):November 1, 1946Publication History Published online1 May 2002Published inissue 1 November 1946https://pubs.acs.org/doi/10.1021/ja01215a063https://doi.org/10.1021/ja01215a063research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Ageing Heat Treatment on the Hardness and Tensile Properties of Aluminum A356.2 Casting Alloy (2009)

The aluminium A356.2 casting alloy is one of most popular alloys for shaped casting of automotive components because of its high strength to weight ratio and the ability to heat treat to attain fairly high toughness. Besides Al, the alloy has Si and Mg as the principal alloying additions to aid in the precipitation of the Mg<sub>2</sub>Si phase in the primary Al matrix to strengthen the alloy during heat treatment. Presently, the T6 heat treatment temper is most used on cast components from these alloys. Commercially, in the T6 temper, the component is solution heat treated at around 540<sup>◦</sup>C for about 10 to 12 hours immediately followed by quenching in water maintained at 80<sup>◦</sup>C. The component is then left to natural age at room temperature for about 8 to 10 hours followed by artificial ageing at around 155<sup>◦</sup>C for about 6 to 10 hours. This T6 temper treatment process has been followed for many years and adopted from the 6xxx series Al wrought alloy where the strengthening precipitate is Mg<sub>2</sub>Si as well. No significant research has been carried out to evaluate to optimize the T6 heat treatment in A356.2 casting alloys, specifically, the natural ageing phenomenon adopted from the 6xxx series alloy where the Si to Mg ratio is between 1 and 3, has not been optimized in A356.2 alloy, wherein, the ratio Si to Mg is between 4 and 6. Hence, the mechanism of redistribution of Mg and Si atoms during the natural and artificial ageing process would have to be studied for the A356.2 alloy and the process optimized to attain favourable mechanical properties. In this study, the mechanism of Mg and Si atoms redistribution during the process of natural ageing has been proposed. Additionally, the effect of natural ageing combined with the artificial ageing process on the mechanical properties of the cast component has been quantified. The results of this study propose that the extent of natural ageing in A356.2 alloy depends on the desired combination of strength and elongation in the cast component. A high strength (~230 MPa) and low elongation (~2%) could be achieved if the natural ageing process at room temperature is limited to less than one hour after solution heat treatment and quenching in water at 80°C, and low strength (~195 MPa) and high elongation (~8%) could be achieved for natural ageing of about 6 hours at room temperature prior to the artificial ageing treatment. The recommendations are valid for solutionizing the components at 540<sup>◦</sup>C for 12 hours, followed by quenching in water at 80<sup>◦</sup>C and an artificial ageing at 155<sup>◦</sup>C for various times.
EFFECT OF DIETHYLSTILBESTROL ON THE BINDING OF THYROXINE IN SERUM*† (1956)

An apparent paradox in thyroidal economy is presented by the normally pregnant woman. Thus, there occurs during pregnancy thyroidal hyperplasia, augmentation of the thyroidal accumulation of radioiodine, and an increase in the concentration of circulating thyroid hormone (1–5). These changes, ordinarily associated with the thyrotoxic state, are not accompanied during pregancy by symptomatic stigmata of thyrotoxicity nor by increases in basal oxygen consumption beyond those which have been attributed to fetal needs (6).
PERIPHERAL NERVOUS SYSTEM IN A CASE OF CANINE GIANT AXONAL NEUROPATHY (1979)

The pathology of the peripheral nerves in a dog with naturally occurring giant axonal neuropathy (GAN) is described. Axonal swellings were found predominantly in the distal portions of the tibial and recurrent laryngeal nerves. Excess neurofilaments, often arranged in whorls, were present in the swellings which were found in both myelinated and non-myelinated fibres. Other axonal organelles tended to be isolated in small pockets and on occasions adaxonal Schwann cell processes partially separated these organelles from the axoplasm. The myelin sheath was attenuated over the swellings and short lengths of demyelinated axon were often seen adjacent to the enlargements. Some Schwann cells also contained excessive microfilaments. The peripheral nerve pathology in the dog appear closely similar to that of human GAN and to certain experimental toxic neuropathies, particularly those produced by n-hexane and methyl-butyl ketone.
Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis (2010)

Neuronal ceroid lipofuscinoses (NCLs) constitute a group of progressive neurodegenerative disorders resulting from mutations in at least eight different genes. Mutations in the most recently identified NCL gene, MFSD8/CLN7, underlie a variant of late-infantile NCL (vLINCL). The MFSD8/CLN7 gene encodes a polytopic protein with unknown function, which shares homology with ion-coupled membrane transporters. In this study, we confirmed the lysosomal localization of the native CLN7 protein. This localization of CLN7 is not impaired by the presence of pathogenic missense mutations or after genetic ablation of the N-glycans. Expression of chimeric and full-length constructs showed that lysosomal targeting of CLN7 is mainly determined by an N-terminal dileucine motif, which specifically binds to the heterotetrameric adaptor AP-1 in vitro. We also show that CLN7 mRNA is more abundant in neurons than astrocytes and microglia, and that it is expressed throughout rat brain, with increased levels in the granular layer of cerebellum and hippocampal pyramidal cells. Interestingly, this cellular and regional distribution is in good agreement with the autofluorescent lysosomal storage and cell loss patterns found in brains from CLN7-defective patients. Overall, these data highlight lysosomes as the primary site of action for CLN7, and suggest that the pathophysiology underpinning CLN7-associated vLINCL is a cell-autonomous process.
CREATING A LOC BASED PORTABLE HEALTH-CARE PLATFORM - Using a Universal Mobile NFC Host Environment (2009)

This paper presents our recent plan to provide support for a portable diagnostic health care platform (namely POCEMON) based on Lab-On-Chip (LOC) concept. The idea is based on our achievements on creating a host environment that combines mobile phones/PDAs with the Near Field Communication (NFC) wireless technology to further support mobile diagnostic health care applications. NFC enabled mobile phone based host environment works as a reference platform regardless of the phone type and the nature of the services required. In connection to this, we will describe further insights on how this cutting edge technology may be leveraged in the health care sector providing efficient point-of-care monitoring and diagnosis.
Abolition of cyclic flow variations in stenosed, endothelium-injured coronary arteries in nonhuman primates with a peptide fragment (VCL) derived from human plasma von Willebrand factor-glycoprotein Ib binding domain. (1994)

Therefore, administration of a peptide fragment corresponding to von Willebrand-glycoprotein Ib binding domain (1) is effective in abolishing cyclic flow variations in stenosed, endothelium-injured coronary arteries and (2) reduces platelet aggregation in vivo in response to botrocetin in nonhuman primates.
PP/EMA TPV: Dynamic cross‐linking through an alcoholysis reaction (2002)

Abstract Dynamically cross‐linked polypropylene/ethylene‐methyl acrylate copolymer (PP/EMA) blends were prepared by reactive extrusion in a twin‐screw extruder. A transesterification reaction catalyzed by an organotin compound and involving the acrylic moieties of EMA with the hydroxyl functions of pentanediol was used to cross‐link the elastomeric EMA. The extent of cross‐linking was estimated through the insoluble content of the blend. The alcohol‐to‐acrylic ratio and the dibutyltin oxide content were both found to increase the extent of EMA cross‐linking. Processing conditions such as screw rotation rate and extrusion temperature profile also had large effects on the reaction extent. Conditions leading to improved pentanediol dispersion were found to generate larger insoluble fraction. Gel contents of EMA phase as high as 75% to 85% were obtained. Interestingly, the stress‐strain curves of the cross‐linked PP/EMA TPV are very well represented by a single master curve. Dynamically cross‐linked blends show systematically better tensile properties than the non‐reactive system. Blends with higher insoluble content show strain at break in the 650%–750% range. Material processability was maintained, even for the systems with high insoluble content.
Mechanism of action of local anesthetics. 1. Theories of action, questions, and means of solution (1972)

A review, with 34 refs., of 3 theories of local anesthetic action: displacement of transmitters by anesthetics; inhibition of enzymes required for ion transport; nerve membrane stabilization by binding of local anesthetics to membrane structures.
Automatic K-complex detection using Hjorth parameters and fuzzy decision (2010)

K-complex is a stereotyped transient wave in the human electroencephalogram (EEG), it appears frequently during sleep recordings. Its role and significance have been disregarded since its discovery until recently, when the American Association of Sleep Medicine (AASM) proposed a new classification of sleep with a relevant role for the K-complexes in the definition of the sleep stages. It is now one of the key features that contribute to sleep stage assessment. K-complexes are associated with sleep arousal and can occur spontaneously or as an evoked response to external stimuli. Since the EEG has a stochastic nature, K-complex can have a wide variety of shapes and it can be difficult to distinguish it from other EEG waves. The visual scoring of K-complex is a very complex, time consuming and expensive procedure and reported agreement between human expert scorers is very poor. In this paper a new method for K-complex automatic detection is presented. The detection method is based on Hjorth parameters and employs fuzzy decision. The performance of the detection system is compared to the visual human scoring.
(−)-1<i>R</i>-8-Hydroxy-4-<i>p</i>-menthen-3-one Isolated from Essential Oil of<i>Mentha gentilis</i>L. (1975)

Journal Article (−)-1R-8-Hydroxy-4-p-menthen-3-one Isolated from Essential Oil of Mentha gentilis L. Get access Tôru Nagasawa, Tôru Nagasawa Laboratory of Chemistry, Nagoya Gakuin University, Kamishinano-cho, Seto-shi 480-12; Search for other works by this author on: Oxford Academic Google Scholar Kazuyasu Umemoto, Kazuyasu Umemoto Laboratory of Chemistry, Nagoya Gakuin University, Kamishinano-cho, Seto-shi 480-12; Search for other works by this author on: Oxford Academic Google Scholar Tomoyuki Tsuneya, Tomoyuki Tsuneya Laboratory of Chemistry, Nagoya Gakuin University, Kamishinano-cho, Seto-shi 480-12;Faculty of Research of Chemistry, Shiono Koryo Co., Ltd., Niitaka, Yodogawa-ku, Osaka-shi 532; Search for other works by this author on: Oxford Academic Google Scholar Minoru Shiga Minoru Shiga Laboratory of Chemistry, Nagoya Gakuin University, Kamishinano-cho, Seto-shi 480-12;Faculty of Research of Chemistry, Shiono Koryo Co., Ltd., Niitaka, Yodogawa-ku, Osaka-shi 532; Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 39, Issue 2, 1 February 1975, Pages 553–554, https://doi.org/10.1080/00021369.1975.10861633 Published: 01 February 1975 Article history Received: 10 June 1974 Published: 01 February 1975
Selective blockage of K<sub>v</sub>1.3 and K<sub>v</sub>3.1 channels increases neural progenitor cell proliferation (2006)

The modulation of cell proliferation in neural progenitor cells (NPCs) is believed to play a role in neuronal regeneration. Recent studies showed that K(+) channel activity influenced cell proliferation. Therefore, we examined NPCs for K(+) channels and tested whether NPC self renewing can be modulated by synthetic K(+) channel modulators. The whole-cell K(+) current was partly K(+) dependent and showed a cumulative inactivating component. Two tetra-ethyl-ammonium ion (TEA)-sensitive K(+) currents with different voltage dependencies ( = 65 microm, E(50) = -0.3 +/- 1.3 mV and = 8 mm, E(50) = -15.2 +/- 2.8 mV) and an almost TEA-insensitive current were identified. Kaliotoxin blocked approximately 50% of the entire K(+) currents (IC(50) = 0.25 nm). These properties resembled functional characteristics of K(v)1.4, K(v)1.3 and K(v)3.1 channels. Transcripts for these channels, as well as proteins for K(v)1.3 and K(v)3.1, were identified. Immunocytochemical staining revealed K(v)1.3 and K(v)3.1 K(+) channel expression in almost all NPCs. The blockage of K(v)3.1 by low concentrations of TEA, as well as the blockage of K(v)1.3 by Psora-4, increased NPC proliferation. These findings underline the regulatory role of K(+) channels on the cell cycle and imply that K(+) channel modulators might be used therapeutically to activate endogenous NPCs.