gebhart/patrepeval huggingface dataset:
Microtubule organization in presynaptic boutons relies on the formin DAAM (2018)

Regulation of the cytoskeleton is fundamental to the development and function of synaptic terminals, such as neuromuscular junctions. Despite the identification of numerous proteins that regulate synaptic actin and microtubule dynamics, the mechanisms of cytoskeletal control during terminal arbor formation have remained largely elusive. Here, we show that DAAM, a member of the formin family of cytoskeleton organizing factors, is an important presynaptic regulator of neuromuscular junction development in <i>Drosophila</i> We demonstrate that the actin filament assembly activity of DAAM plays a negligible role in terminal formation; rather, DAAM is necessary for synaptic microtubule organization. Genetic interaction studies consistently link DAAM with the Wg/Ank2/Futsch module of microtubule regulation and bouton formation. Finally, we provide evidence that DAAM is tightly associated with the synaptic active zone scaffold, and electrophysiological data point to a role in the modulation of synaptic vesicle release. Based on these results, we propose that DAAM is an important cytoskeletal effector element of the Wg/Ank2 pathway involved in the determination of basic synaptic structures, and, additionally, that DAAM may couple the active zone scaffold to the presynaptic cytoskeleton.
Experimental evaluation of junction circulators: a review (1994)

The adjustment of any microwave device should always reflect as far as possible its physical properties. The purpose of the paper is to summarise existing experimental techniques for the characterisation of the classic 3-port junction circulator for which the inphase eigennetwork may be approximately represented by an electric wall boundary condition. Some important possibilities include its matrix descriptions, its corresponding eigenvalues and its complex gyrator circuit. New experimental techniques for the evaluation of the immittances and frequencies of the split eigennetworks are separately described.
Localization of 4.1 related proteins in cerebellar neurons. (1989)

Localization of 4.1 related proteins in neurons was studied with immunofluorescence microscopy and with immunoelectron microscopy on ultrathin cryosections. In rat cerebellum, 4.1 immunoreactive proteins were demonstrated in Purkinje cell bodies, dendrites and other neurons in the cerebellar cortex. Some glial cells showed staining, but no labeling was found in myelinated axons of the white matter and of the glomeruli in the granule cell layer. At the ultrastructural level, the 4.1 related proteins were localized mainly in the cytoplasmic matrix, while some labeling was found underneath the plasma membrane. To determine whether 4.1 related proteins in neuronal cytoplasm exist as part of the cytoskeleton or not, PC12 cells cultured in the presence of nerve growth factor were stained with the anti-4.1 antibody. Since cytoplasmic staining was retained after detergent treatment, the 4.1 related proteins seem to exist as a component of the neural cell cytoskeleton. Localization of 4.1 related proteins during the postnatal development of the cerebellum was also studied. In Purkinje cells, localization of 4.1 related proteins changed according to the stages of the postnatal development. The present data suggest that 4.1 related proteins in neurons localized mainly in the cytoplasm and may play some role in organizing cytoskeletal networks in the cytomatrix. Their distribution is developmentally regulated in some neurons, possibly in relationship to their maturation in the cytoskeleton.
Transition phase issues. [LMFBR] (1979)

The safety issues associated with the transition (core disruption) phase of hypothetical LMFBR accidents are identified and discussed. This discussion is intended to serve as a basis for defining future experimental needs to support core disruption analysis, and for defining analytical code developments required to support the licensing process and experimental analysis.
Optimization of surface finish in ultra-precision raster milling (2005)

3rd International Conference on Leading Edge Manufacturing in 21st Century, LEM 2005, Nagoya, 19-22 October 2005
Magnetic Resonance Imaging of the Chest, Abdomen, and Pelvis in the Evaluation of Pregnant Patients with Neoplasms (2007)

This article illustrates the magnetic resonance (MR) technique and MR imaging (MRI) findings of various neoplasms in chest, abdomen, and pelvis in pregnant patients. MRI can provide useful information about characterization and staging of maternal neoplasms without exposing the fetus to ionizing radiation and can be considered as a first-line cross sectional imaging method as an adjunct to ultrasonography.
Production and Application of Carbon Nanotubes (2003)

Single-wall carbon nalimithes (SWNTs) htve unique structures with diameters of nanometer scales and length of mieromemrs or longer. Their properties are interesting, for example. high tensile strength and electrical properties of both semiconductors and metals depending on their structural symmetries. However. their production methods have not been well established. In this review, the methods of formation. purdication. and purity estimation of SWNTs are introduced. We also introduce single-wall carbon nanohorns (SWNH) that have SWNT-like structures and usually torm spherical aggregates with diameters fo 80-100nm. Two types of SWND aggregates are known, dahlia and bud types. They are produced by CO2 laser ablation at room temperature. Dahlia and bud types of SWNH aggregates are produced with purities of 90%, and 70%, respectively. Among SWNH properties, gas adsorption phenomena are interesting. For example. specific surface area increases from about 300m2/g to 1000m2/g by Heating in oxygen gas at 420°C.
Inhibition of cyclic AMP-triggered aromatase gene expression in human choriocarcinoma cells by antisense oligodeoxynucleotide. (1994)

Aromatase, an endomembrane-bound cytochrome P450, is the key enzyme of estrogen biosynthesis. Aromatase inhibitors, therefore, are clinically important tools in the treatment of estrogen-dependent tumor growth. To improve the specificity of these tools, inhibition at the nucleic acid level was examined. An antisense oligodeoxynucleotide complementary to the translation start region of human aromatase transcripts (antisense-arom) was synthesized and used to inhibit cyclic AMP-triggered aromatase gene expression in a human choriocarcinoma cell line (JEG-3), both as occurring in an autocrine fashion by secreted human chorionic gonadotropin or as induced by application of the membrane-permeating dibutyryl cyclic AMP. Significant inhibition was obtained in both cases, reaching 70% and 60%, respectively. In addition, the antisense-arom treatment led to accelerated mRNA degradation. The inhibition at the nucleic acid level was accompanied by a decrease of both the aromatase protein and microsomal aromatase activity. The data appear to indicate the antisense strategy to be a most promising approach for the development of a novel type of specific aromatase inhibitor.
Laser-capture microdissected Schwannian and neuroblastic cells in stage 4 neuroblastomas have the same genetic alterations (2000)

Our results provide evidence that the majority of Schwannian and neuroblastic cells in stage 4 NB are of neoplastic origin, and support the hypothesis of a tumor stem cell capable of development along multiple lineages.
Purification, characterization and tissue distribution of human class theta glutathione s‐transferase T1‐1 (1996)

A high activity glutathione S-transferase T1-1 (GSTT1-1) towards dichloromethane was isolated from human liver cytosol and purified to homogenity in 18.5% yield with a purification factor of 4400-fold. The GSTT1-1 was also isolated from erythrocytes, but the enzyme activity decreased rapidly in the final stages of purification. The purified GSTT1-1-s were homo-dimeric enzymes with a subunit M1 value 25,300 and pI 6 64, as confirmed by SDS-PAGE, IEF and Western blot analysis. The N-terminal amino acid sequences of GSTT1-1 from liver and red blood cells, analyzed up to the 12th amino acid, were identical. Immunoblot analysis revealed that GSTT1-1 was also present in lung, kidney, brain, skeletal muscle, heart, small intestine and spleen, but not in lymphocytes.
ICA filters for lighting invariant face recognition (2004)

The use of ICA (independent component analysis) for the construction of filters for lighting invariant face recognition is investigated. ICA is used to provide filters which are applied as a pre-processing step to a low dimensional PCA subspace representation of the databases. Test faces imaged under varying illumination from a face database are classified using a support vector classifier. The ICA pre-filter recognition results are compared against those using LoG (Laplacian of Gaussian) filter of various spatial resolutions and no pre-filtering. The ICA pre-filters are shown to be very effective at selectively reducing the effect of illumination variance in object and face recognition without the need for tuning the filters to the orientations and spatial resolutions present in the images.
Experimental multipath time spread in a bathymetrically complex coastal environment (2002)

An acoustic survey was conducted that covered both the continental shelf and slope regions in water depths from 40 m to greater than 1000 m. The types of bathymetric conditions encountered included those likely to be found in any coastal environment. At the benign end of the spectrum a relatively smooth bottom with small slopes connected the shelf and slope. In another area the shelf was relatively short and extended to water depths of approximately 100 m, followed by very steep continental slopes bordered by canyon walls. Intermediate conditions consisted of a short shelf and large continental slopes without canyon walls. Broadband (12 Hz to 4 kHz) acoustic measurements were made under strongly downward-refracting sound-speed conditions using impulsive sources at two different depths. The source at 18 m was in a deep (approximately 40 m) weak surface duct. A strong sound-speed gradient separated this source from the 86-m source depth. The impulsive data have been processed to extract a measure of the effective multipath time spread. Results will be presented showing the sensitivity to source depth, frequency range from the receiver, and bathymetric conditions.
GENERATION AND OPTIMIZATION OF LOCAL SHAPE DESCRIPTORS FOR POINT MATCHING IN 3-D SURFACES (2009)

Thesis (Ph.D, Electrical & Computer Engineering) -- Queen's University, 2009-09-01 11:07:32.084
Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (2020)

BI 836826 is a chimeric immunoglobulin G1 antibody targeting CD37, a tetraspanin transmembrane protein predominantly expressed on normal and malignant B cells. This phase I, open-label study used a modified 3 + 3 design to evaluate the safety, maximum tolerated dose (MTD), pharmacokinetics, and preliminary activity of BI 836826 in patients with relapsed/refractory B cell non-Hodgkin lymphoma (NHL; NCT01403948). Eligible patients received up to three courses comprising an intravenous infusion (starting dose: 1 mg) once weekly for 4 weeks followed by an observation period of 27 (Course 1, 2) or 55 days (Course 3). Patients had to demonstrate clinical benefit before commencing treatment beyond course 2. Forty-eight patients were treated. In the dose escalation phase (1-200 mg) involving 37 Caucasian patients, the MTD was 100 mg. Dose-limiting toxicities occurred in four patients during the MTD evaluation period, and included stomatitis, febrile neutropenia, hypocalcemia, hypokalemia, and hypophosphatemia. The most common adverse events were neutropenia (57%), leukopenia (57%), and thrombocytopenia (41%), and were commonly of grade 3 or 4. Overall, 18 (38%) patients experienced infusion-related reactions, which were mostly grade 1 or 2. Preliminary evidence of anti-tumor activity was seen; three patients responded to treatment, including one complete remission in a Korean patient with diffuse large B cell lymphoma. BI 836826 plasma exposure increased more than proportionally with increasing doses. BI 836826 demonstrated preliminary activity; the most frequent adverse events were hematotoxicity and infusion-related reactions which were manageable after amending the infusion schedule. Although BI 856826 will not undergo further clinical development, these results confirm CD37 as a valid therapeutic target in B cell NHL.
Hopping model of photogalvanic effect in ferroelectrics (1987)

A hopping mechanism of photogalvanic effect (PGE) in ferroelectrics is proposed. PGE arises due to asymmetry of inter-center photoexcitation and recombination of localized electrons. Calculation of the effect is carried out in a model of dipole impurities. The dipole moment of the impurity mixes states of opposite parity of localized electron. This mixing leads to asymmetry of electron wave functions. Therefore matrix elements describing photoexcitation to the excited state of nearest neighbour are different for the left and right neighbours. Magnitude of the matrix elements is determined by exponential tails of the wave functions. The cases of high and low compensation are considered. Estimations of the PGE current and the Glass constant are carried out and it is shown that they are in agreement with experimental values. In case of an isolated crystal static electric field arises. Its value can be very large (E ∼ 104-105 v/cm) because of low mobility of photoelectrons.
A Ternary Complex Reagent for an Asymmetric Reaction of Lithium Ester Enolates with Imines (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Ternary Complex Reagent for an Asymmetric Reaction of Lithium Ester Enolates with IminesHiroki Fujieda, Motomu Kanai, Takeshi Kambara, Akira Iida, and Kiyoshi TomiokaView Author Information Faculty of Pharmaceutical Sciences Kyoto University, Sakyo, Kyoto 606-01, Japan ISIR, Osaka University Mihogaoka, Ibaraki, Osaka 567, Japan Cite this: J. Am. Chem. Soc. 1997, 119, 8, 2060–2061Publication Date (Web):February 26, 1997Publication History Received15 October 1996Published online26 February 1997Published inissue 1 February 1997https://pubs.acs.org/doi/10.1021/ja963581uhttps://doi.org/10.1021/ja963581urapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1526Altmetric-Citations171LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Enolates,Lithium,Organic compounds,Reactivity Get e-Alerts
Ultrasonic Measurement of EHL Oil Films in a Mixed Regime Contact (2006)

In applications, such as gears and rolling bearings, where concentrated contact occurs, extreme loading can result in damaging asperity contact. To study this, an adapted elastohydrodynamic rig was used to measure the film using the reflection of an ultrasonic pulse. Ultrasonic reflection depends on the stiffness of the contact interface. The stiffness of an oil film depends on its thickness. A single contact was operated dry, full film lubricated, and in the mixed regime, by changing the sliding speed. The reflection then depends on the stiffness of both the liquid contact (oil film) and the solid (asperity) contact, acting as two springs in series. When dry, the solid stiffness dominates. As an oil film starts to form, a high stiffness thin liquid film forms. As the speed is increased the stiffness of this layer reduces, as its thickness increases, until it becomes thicker than the roughness and the stiffness then originates from liquid contact alone. By comparing dry, wet and sliding conditions the contributions of solid and liquid stiffness can be separated.Copyright © 2006 by ASME
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids (2019)

Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines. Its pain-relieving mechanism of action is attributed to mild μ-opioid receptor agonism, serotonin and norepinephrine mediated nociception modulation, and N-methyl-D-aspartate receptor, NMDAR, antagonism. However, recent case reports and case-control studies have shown an association between tramadol use and hypoglycemia. The growing concern over increasing tramadol use and unexpected side effects warranted a further comparative and quantitative analysis of tramadol adverse reactions. In this study we analyzed over twelve million reports from United States Food and Drug Administration Adverse Event Reporting System and provided evidence of increased propensity for hypoglycemia in patients taking tramadol when compared to patients taking other opioids, serotonin-norepinephrine reuptake inhibitors, and drugs affecting NMDAR activity. Additionally, we identified that only methadone from the opioid cohort behaves similarly to tramadol and has an association with hypoglycemia.
KUL and EPFL cooperation on numerical integration of Sommerfeld integrals (2012)

This paper reports the result of the cooperation between KUL and EPFL on the numerical integration of Sommerfeld integrals (SI). Each institution is well-known for developing specific techniques suited for the evaluation of SI: double-exponential quadrature rules to take the tail of the integral into account (EPFL) and an asymptotic extraction technique to remove the singularities (KUL). The combination of these two techniques results in a very promising algorithm, allowing to perform the integration along the real axis only. Several examples illustrate the algorithm efficiency.
Induction and suppression of glutathione transferases by interferon in the mouse. (1987)

The administration of interferon-alpha/beta to female nude (nu/nu) mice caused significant changes in the levels of the cytosolic hepatic glutathione transferases. Antibodies raised against rat subunits, Ya, Yc, Yb1, Yb2, and Yk, and the subunits of the human transferases, mu (YbYb), lambda (YfYf), and epsilon (B1B1) all reacted with enzymes in the mouse and were used to demonstrate suppression and induction of transferase levels. Western blot analysis followed by semiquantitation by laser scanning showed the Ya, Yb1, Yb2, Yc, Yk, mu, and B1 subunits to be suppressed by 11, 11, 44, 30, 12, 14, and 47%, respectively, by interferon treatment. In contrast to these findings, the Yf subunit was induced 5-7-fold. A concomitant 220% increase was observed in the specific activity of the hepatic cytosol for ethacrynic acid, a substrate for the Yf subunit. Changes in the levels of transferase enzymes in normal and tumor cells may have significant implications when cytotoxic drugs are used in combination with interferons in cancer therapy. The Yf subunit, an enzyme found in human tumors and in placenta (Polidoro, G., Di Mio, C., Del Boccio, G., Zulli, P., and Fererici, G. (1980) Biochem. Pharmacol. 29, 1677-1680) has also been shown to be elevated in hepatic preneoplastic lesions (Kitahara, A., Satoh, K., Nishimura, K., Ishikawa, T., Ruike, K., Sato, K., Tsuda, H., and Ito, N. (1984) Cancer Res. 44, 2698-2703). These data indicate that the Yf subunit represents a potentially important interferon-inducible gene product.
Interleukin-1-induced anorexia in the rat. Influence of prostaglandins. (1989)

The anorexia associated with acute and chronic inflammatory or infectious conditions is poorly understood. Our objectives were to explore the anorexigenic effects of interleukin-1 (IL-1) in the rat. Recombinant human (rh) IL-1 beta, murine (rm) IL-1 alpha and to a lesser extent rhIL-1 alpha significantly reduced food intake at greater than or equal to 4.0 micrograms/kg i.p. but not at lower doses, in young (200-250 g) meal-fed rats on chow diets. The anorexic effect appears to be mediated by prostaglandins since pretreatment with ibuprofen completely blocked it, and a fish oil based diet abolished it, in comparison to corn oil or chow diets. Fish oil feeding also decreased basal and IL-1 stimulated prostaglandin E2 production by tissues in vitro (liver, brain, peritoneal macrophages) and in the whole body. Constant intravenous infusions of lower doses of IL-1 also diminished food intake, though intravenous boluses did not (reflecting rapid renal clearance). Chronic daily administration of IL-1 caused persistent inhibition of food intake for 7-17 d in chow and corn oil fed rats, but had no effect in fish oil fed rats. There was an attenuation of the effect (tachyphylaxis) after 7 d in corn oil and chow fed rats, but slowed weight gain and lower final weights were observed after 17-32 d of daily IL-1. Old (18-20 mo Fisher 344) rats showed less sensitivity to IL-1 induced anorexia. In conclusion, IL-1 is anorexigenic in the rat, but this is influenced by the structural form of IL-1, the route and chronicity of administration, the source of dietary fat, and the age of the animal. The ability of prior fat intake to influence the anorexic response to IL-1 represents a novel nutrient-nutrient interaction with potential therapeutic implications.
Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease† (2004)

Chronic liver disease has been shown to be associated with diminished humoral and cellular immune function. Although antigen-presenting cells (APC) that initiate immune responses include various cells (B cells, endothelial cells, macrophages, etc.), the dendritic cell (DC) is a professional APC that activates naive T cells most efficiently. To examine the frequency and function of DCs in chronic liver disease, we studied circulating DCs from a cohort of 112 subjects (23 normal subjects, 29 subjects who had spontaneously recovered from hepatitis C virus [HCV] infection, 30 chronically infected HCV patients, and 30 patients with liver disease unrelated to HCV infection). Our analyses revealed significant reduction in both circulating myeloid (mDC) and plasmacytoid dendritic cells (pDC) in patients with liver disease. In contrast, examination of subjects with spontaneously resolved HCV infection revealed no significant difference in either circulating mDCs or pDCs. We found an inverse correlation with serum alanine aminotransferase (ALT) levels and both mDCs and pDCs frequency. In a subset of patients for whom intrahepatic cells were available, paired analysis revealed enrichment for DCs within the intrahepatic compartment. Interferon alfa (IFN-alpha) production in response to influenza A and poly (I:C) correlated with the frequency of circulating DCs, although IFN-alpha production was comparable on a per-DC basis in patients with liver disease. In conclusion, patients with liver disease exhibit a reduction in circulating DCs. Considering that DCs are essential for initiation and regulation of innate and adaptive immunity, these findings have implications for both viral persistence and liver disease.