gebhart/patrepeval huggingface dataset:
Secondary transport of metal–citrate complexes: the CitMHS family (2010)

Primary and secondary transport of citrate has been extensively studied in pathogenic and non-pathogenic bacteria. Primary transporters of citrate complexed with metal ions, particularly Fe, have also garnered attention, with the fec system of E. coli being a classic example. In contrast, little is known about secondary transporters of metal-citrate complexes. Recently, a family of proteins responsible for secondary metal-citrate transport in bacteria was discovered and designated as the CitMHS transporter family. Several members have been functionally characterized to date and serve as the foundation for understanding this family. Three subfamilies have been categorized, depending on the main metal ion transported. These subfamilies are the Mg(2+)-citrate transporter, the Ca(2+)-citrate transporter, and the Fe(3+)-citrate transporter. Each subfamily is believed to be substrate-selective due to the metal-citrate complexes being abundantly present in their environment and/or the ability of the complex to be metabolized by the organism. The implication of this family in the pathogenic access to Fe, information about transcriptional control, putative structure, predicted family members, members characterized to date and potential use in bioremediation are discussed.
Time-dependent trends in cardiovascular adverse events during follow-up after carotid or iliofemoral endarterectomy (2017)

In patients who had undergone either CEA or IFE there was no evidence of a decrease in all secondary cardiovascular events. There were no differences in major cardiovascular events.
Effectiveness of the 4-Poster Passive Topical Treatment Device in the Control of <i>Ixodes scapularis</i> and <i>Amblyomma americanum</i> (Acari: Ixodidae) in New Jersey (2009)

Twenty-five "4-Poster" feeders were placed throughout a 5.2 km(2) study area within a secured military facility situated in a hyperendemic area for Lyme disease in central Monmouth County, New Jersey. Calculated levels of control, relative to untreated areas, peaked at 82.7%, 77.3%, and 94.2% for of host-seeking Ixodes scapularis Say larvae, nymphs, and adults, respectively, within 5 years of deployment. Control of host-seeking Amblyomma americanum (L.) peaked at 99.2%, 89.5%, and 96.9% for larvae, nymphs, and adults, respectively, during the treatment period. Tick burdens on hunter-killed deer were significantly reduced on deer harvested from the treatment area and on deer that had consumed bait corn. Populations of subadult I. scapularis and A. americanum demonstrated some rebound effect following the removal of 4-Posters, but treatment area tick populations remained lower than control area populations 2 years following withdrawal of the 4-Posters. However, control of I. scapularis adults declined to 20.7% by the third fall activity period following removal of the 4-Posters. The posttreatment phase of the study was of insufficient duration to evaluate continued population rebound of adults and subadults during subsequent activity periods.
Multiple inhibitor binding to arsanilazotyrosine-248 carboxypeptidase A (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple inhibitor binding to arsanilazotyrosine-248 carboxypeptidase AGerald M. Alter and Bert L. ValleeCite this: Biochemistry 1978, 17, 11, 2212–2218Publication Date (Print):May 30, 1978Publication History Published online1 May 2002Published inissue 30 May 1978https://pubs.acs.org/doi/10.1021/bi00604a030https://doi.org/10.1021/bi00604a030research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electromagnetic actuator for generating variably oriented shear waves in MR elastography (2003)

Magnetic resonance elastography (MRE) is a recently developed technique for determining the mechanical properties of biological tissue. In dynamic MRE, electromagnetic units (actuators) are widely used to generate shear waves in tissue. These actuators exploit the interaction between the static magnetic field B(0) and an annular coil supplied with alternating currents. Therefore, coil movements are restricted to selected orientations to B(0). Conventional actuators transfer this movement collinearly to B(0) into the tissue. In this study, an electromagnetic actuator was introduced that overcomes this limitation. It is demonstrated that different directions of mechanical excitation can be generated and monitored by MRE. Different spatial components of the propagation of the shear waves were determined using agarose phantoms. The technique allows maximum contrast for MRE images of objects with anisotropic strain components such as muscle tissue.
Single-Crystalline Ferromagnetic Mn<sub>4</sub>Si<sub>7</sub> Nanowires (2009)

We report the synthesis of single-crystalline Mn4Si7 nanowires using SiO and MnCl2 powders via the chemical vapor deposition method and their ferromagnetic properties. It is shown from XRD and TEM analyses that the synthesized nanowires have single-crystalline tetragonal Mn4Si7 structure with the growth direction along [002]. The magnetic measurements indicate that the nanowires are ferromagnetic with a Curie temperature of 120 K. In addition, it is found that the nanowires are degenerately doped. These results suggest that the ferromagnetic Mn4Si7 nanowires could be employed for Si-based spintronic nanodevices coupled with complementary metal−oxide−semiconductor integrated circuits.
Books on India and Central Asia - 7. Portfolio of Indian Art. Edited by Ananda K. Coomaraswamy. 108 plates, with 108 pp. of letterpress. Boston: Museum of Fine Arts (also New York: E. Weyhe, and others). (1924)

Books on India and Central Asia - 7. Portfolio of Indian Art. Edited by Ananda K. Coomaraswamy. 108 plates, with 108 pp. of letterpress. Boston: Museum of Fine Arts (also New York: E. Weyhe, and others). - Volume 56 Issue 2
Detecting buried objects with subwavelength resolution using a near-field antenna-array probe (2011)

Summary form only given, as follows. A near-field antenna-array probe is used to perform subwavelength imaging on objects buried λ/4 beneath the surface of a dielectric slab. Short passive dipole objects are detected by monitoring the input reflection coefficient of the probe as it is scanned over the dielectric. Experimental measurements are presented that verify the subwavelength imaging behavior. A minimum resolvable separation between two objects was measured to be 0.295λ, compared to 0.639λ for a single monopole probe.
Identification of Nuclear Receptor Interacting Proteins Using Yeast Two-Hybrid Technology: Applications to Drug Discovery (2003)

The yeast two-hybrid system is a powerful tool for the isolation and characterization of nuclear receptor interacting proteins such as coactivator and corepressor proteins. Generally coactivators associate with the nuclear receptors in an agonist-dependent manner and this specific protein-protein interaction forms the basis for ligand-mediated transcriptional activation of the target hormone-responsive genes. The association of corepressors with unliganded nuclear receptors allows the target genes to be in a repressed state in the absence of agonists. However depending on the stoichiometry of nuclear receptor coactivator and corepressor proteins in a given cell some degree of receptor/ coactivator interaction can occur resulting in a basal level of gene transcription. The ability of antagonists to maintain this basal equilibrium interaction or to increase receptor-corepressor interaction will determine whether they function as neutral antagonists or inverse agonists.
TUMORS: ROLE OF HEXOKINASE BINDING TO THE OUTER MITOCHONDRIAL MEMBRANE (1988)

One of the earliest biochemical markers for cell transformation is an increase in the rates of uptake and utilization of glucose in the transformed cell line (1-7). Although a direct correlation has been ob­ served between glucose utilization rates and growth rates in avariety of cancer cell lines (2,3,5,6,8), it would appear that elevated glucose catabolism is not strictly a function of cell growth rate per se. Rather, increased levels of plasma membrane glucose transporter and elevated activities of glycolytic enzymes are characteristic of the transformed phenotype (4,6,7,9,10). Recent studies by Lodish and others (11) have shown that elevated levels of glucose transporter protein are induced by transfection with the transforming oncogenes ras and src, but not with the immortalizing oncogene myc. Exposure of cells to tumor promoting phorbol esters pro­ duced effects similar to those seen with ras and src. These changes appeared to be mediated by increased levels of transporter mRNA. Birnbaum et al. (7) reported that increased glucose transport in rat fibroblasts transformed with a temperature sensitive Fujinami sarcoma virus resulted from an increased rate of transcription of glucose trans­ porter gene in the transformed cell line, occurring within thirty min­ utes after shift to the permissive temperature. Interestingly, a number of morphological changes associated with the transformed phenotype can be seen in enucleated chick embryo fibroblasts transformed with a tem­ perature sensitive Rous sarcoma virus after shift to the permissive tem­ perature, while increased glucose transport was dependent upon the presence of a cell nucleus (12). Taken together, these results suggest that control of gene expression is a primary factor involved in eleva­ tion of glucose uptake in cancer cells.
A Simple Way to 3‐[(1<i>R</i>,2<i>S</i>,5<i>R</i> and 5<i>S</i>)‐5‐Methoxymethoxy‐2‐methyl‐1,2‐epoxycyclohexyl]propanal, a Synthon for the Total Biomimetic Synthesis of (‐)‐Progesterone (1989)

The cyclohexylpropanals 21 and 22 were obtained in a 5‐step synthesis, starting from the hydroxy diketone 5 . Rearrangement of the hydroxy lactones 9 and 10 into epoxy esters 19 and 20 , respectively, by potassium hydride in HMPA and 2‐iodopropane was the key step of this synthesis.
An image rejection down-converter for low-IF receivers in 130 nm CMOS (2004)

Implemented in 4.1 mm/sup 2/ in 130 nm CMOS, a dual-conversion image rejection down-converter applied to the WCDMA standard draws 13 mA from 1.8 V. Using an IF of 2.5 MHz, the WCDMA image rejection band is widened from between 0.58 MHz and 4.42 MHz to between 0.48 MHz and 5.2 MHz - a bandwidth ratio of 10.8 - to accommodate process, voltage, and temperature variations in high-volume production. Ten samples are measured and fully characterized: average image rejection ratio (IRR) is 46.6 dBc; gain is 12 dB; NF is 10.8 dB. Typical IRR is 44.8 dBc, 46.5 dBc, and 47.5 dBc at -20/spl deg/C, 25/spl deg/C, and 80/spl deg/C, respectively.
Efficient, Two‐Step Synthesis of N‐Substituted Nortropinone Derivatives. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Overpressure and petroleum generation and accumulation in the Dongying Depression of the Bohaiwan Basin, China (2001)

Abstract The occurrence of abnormally high formation pressures in the Dongying Depression of the Bohaiwan Basin, a prolific oil‐producing province in China, is controlled by rapid sedimentation and the distribution of centres of active petroleum generation. Abnormally high pressures, demonstrated by drill stem test (DST) and well log data, occur in the third and fourth members (Es3 and Es4) of the Eocene Shahejie Formation. Pressure gradients in these members commonly fall in the range 0.012–0.016 MPa m −1 , although gradients as high as 0.018 MPa m −1 have been encountered. The zone of strongest overpressuring coincides with the areas in the central basin where the principal lacustrine source rocks, which comprise types I and II kerogen and have a high organic carbon content (>2%, ranging to 7.3%), are actively generating petroleum at the present day. The magnitude of overpressuring is related not only to the burial depth of the source rocks, but to the types of kerogen they contain. In the central basin, the pressure gradient within submember Es32, which contains predominantly type II kerogen, falls in the range 0.013–0.014 MPa m −1 . Larger gradients of 0.014–0.016 MPa m −1 occur in submember Es33 and member Es4, which contain mixed type I and II kerogen. Numerical modelling indicates that, although overpressures are influenced by hydrocarbon generation, the primary control on overpressure in the basin comes from the effects of sediment compaction disequilibrium. A large number of oil pools have been discovered in the domes and faulted anticlines of the normally pressured strata overlying the overpressured sediments; the results of this study suggest that isolated sandstone reservoirs within the overpressured zone itself offer significant hydrocarbon potential.
Rayonnement panoramique d'un train d'impulsions brèves par un laser à Rhodamine 6G dont le résonateur est fermé en géométrie cylindrique (1981)

A "halo" type laser system is presented whose radiation is characterized by a propagation planar beam rather than a unidirectional beam. A doubled Nd:glass laser mode-locked picosecond pulse train is used to pump a Rhodamine 6G dye solution filling a cylindrical closed resonator. The laser short pulse train propagates in a plane across 360°, with mrad divergence transversely to the propagation plane.
Synthesis and Reactivity of Functionalized Dimethylsilyl Complexes of the Formula (η<sup>5</sup>‐C<sub>5</sub>H<sub>5</sub>)Re(NO)(PPh<sub>3</sub>)(SiMe<sub>2</sub>X); New Base‐Stabilized Silylene Complexes, Novel Lewis Acid Adducts, and Evidence for Base‐Free Silylene Complexes (1991)

Abstract Reactions of (η 5 ‐C 5 H 5 )Re(NO)(PPh 3 )(SiMe 2 H) ( 1 ) and CHCl 3 , CBr 4 , and CHI 3 give halosilyl complexes (η 5 ‐C 5 H 5 )Re(NO)‐(PPh 3 )(SiMe 2 X) [X = Cl ( 2 ), Br ( 3 ), I ( 4 ); 66–84%]. Addition of Me 3 SiOTf to 2 gives triflate (η 5 ‐C 5 H 5 )Re(NO)(PPh 3 )(SiMe 2 OTf) (5; 97%), which in turn reacts with (Me 2 N) 3 S ⊕ [SiMe 3 F 2 ] ⊖ to give (η 5 ‐C 5 H 5 )Re(NO)(PPh 3 )(SiMe 2 F) ( 6 ; 77%). Reaction of 5 and pyridine gives the base‐stabilized silylene complex [(η 5 ‐C 5 H 5 )Re(NO)(PPh 3 ){SiMe 2 (NC 5 H 5 )}] ⊕ TfO ⊖ ( 7 ; 84%). CH 2 Cl 2 solutions of (η 5 ‐C 5 H 5 )Re(NO)(PPh 3 )(CH 3 ) ( 8 ) or 2 and Lewis acids are studied by IR and NMR. As assayed by IR, 8 /ECl 3 solutions (E = B, Al) show ReNO–ECl 3 (major) and Re–ECl 3 (minor) adducts. Solutions of 2/BCl 3 show analogous adducts (‐78°C), and in the presence of excess BCl 3 (η 5 ‐C 5 H 5 )Re‐(NO–BCl 3 )(PPh 3 )(SiMe 2 Cl) ( 11 ) crystallizes. Solutions of 2 /AlCl 3 show uncomplexed 2 and Re–AlCl 3 (major) and ReNO–AlCl 3 (minor) adducts. In contrast to 2 – 7 and 2/BCl 3 , 1 H‐ and 13 C‐NMR spectra of 2 /AlCl 3 suggest an equilibrium with the base‐free silylene complex [(η 5 ‐C 5 H 5 )Re(NO)(PPh 3 )‐( = SiMe 2 )] ⊕ X ⊖ .
A novel, mild, specific and indirect maleimido‐based radioiodolabeling method (1992)

In an effort to design a mild, non‐oxidative and site‐specific means of radiolabeling bioactive molecules we have employed maleimido‐sulfhydryl chemistry to produce bioactive hormone radioligands. We have prepared two novel radioiodolabeled reagents, 3′‐maleimidopropanoyl‐3‐ 125 I‐tyramide and its retro analog, N ‐maleoyl‐ N′ ‐3‐(4‐hydroxy‐3‐ 125 I‐phenyl)propanoy1 ethylenediamide, by either oxidative radioiodination of the precursors or radiolabeling of the phenolic component prior to its incorporation into the radiolabeling reagents. These reagents were then used to radiolabel analogs of parathyroid hormone (PTH) and parathyroid hormone‐related protein (PTHrP) in an efficient way, yielding reaction mixtures which were easily purified. The radioligands obtained are stable upon storage and bind in a reversible manner to a single population of binding sites displaying affinity in the low nanomolar range. The potencies of these analogs are comparable to the non‐modified PTH and PTHrP analogs. This study demonstrates the utility of the novel maleimido‐based indirect radioiodination approach and highlights some of its advantages over either direct oxidative procedures or acylation using the Bolton‐Hunter reagent.
The Microstructure of Pure Copper after Stepwise Change of Irradiation Temperature (2005)

In order to investigate the effect of stepwise change of irradiation temperature on pure copper, heavy ion irradiations under constant temperature and varying temperature conditions were performed. Specimens were irradiated up to 10dpa. In the temperature region of 473K ~ 673K, one-step temperature variation and periodic temperature variations were performed during irradiation. The resulting microstructures were compared with those induced by the irradiation at the constant temperature of 673K.
A knowledge-based problem-specific program generator (1987)

A commercially relevant paradigm for a knowledge-based problem-specific program generator is described. It is applicable to repeatedly implemented software, particularly in the intermediate area between the exclusive and standard software. Not the first implementation, but the repeated ones are supported using the "problem-specific programming knowledge" collected during the past implementations. The technical details, as knowledge representation and functional component, are explained and illustrated on an example. Finally, conditions for an efficient application of the program generator are defined. The system can be developed at a relatively low expense of several months.
Preoperative Detection of Hepatocellular Carcinoma: Ferumoxides-Enhanced Versus Mangafodipir Trisodium—Enhanced MR Imaging (2002)

Ferumoxides-enhanced MR imaging has superior diagnostic accuracy in lesions smaller than 10 mm and superior lesion conspicuity compared with mangafodipir trisodium-enhanced MR imaging for the preoperative detection of hepatocellular carcinoma.
Smartphone Camera De-identification while Preserving Biometric Utility (2019)

The principle of Photo Response Non Uniformity (PRNU) is often exploited to deduce the identity of the smartphone device whose camera or sensor was used to acquire a certain image. In this work, we design an algorithm that perturbs a face image acquired using a smartphone camera such that (a) sensor-specific details pertaining to the smartphone camera are suppressed (sensor anonymization); (b) the sensor pattern of a different device is incorporated (sensor spoofing); and (c) biometric matching using the perturbed image is not affected (biometric utility). We employ a simple approach utilizing Discrete Cosine Transform to achieve the aforementioned objectives. Experiments conducted on the MICHE-I and OULU-NPU datasets, which contain periocular and facial data acquired using 12 smartphone cameras, demonstrate the efficacy of the proposed de-identification algorithm on three different PRNU-based sensor identification schemes. This work has application in sensor forensics and personal privacy.
Dietary carotenoid pigments and immune function in a songbird with extensive carotenoid-based plumage coloration (2003)

Carotenoid pigments can directly enhance the immune responses of vertebrates, and they are used by many animals to create ornamental color displays. It has been hypothesized that these two functions of carotenoid pigments are linked: animals must trade off use of carotenoid pigments for immune function versus ornamental display. We tested two key predictions of this hypothesis with captive American goldfinches, <it>Carduelis tristis</it>, a species with extensive carotenoid-based plumage coloration. First, we tested whether the immune systems of male goldfinches are carotenoid limited during molt by supplying treatment groups with low, approximately normal, or high dietary access to lutein and zeaxanthin. Dietary treatment had a significant effect on plumage and bill color but not on immunocompetence. We compared the cell-mediated and humoral immune responses and the course of disease after infection for males in the different treatments. We observed no significant effect of the carotenoid content of diet on immune response or disease resistance. Second, we tested whether there was a positive relationship between immune function and expression of ornamental coloration by comparing both the pre- and posttreatment plumage coloration of males to their immune responses. We failed to find the predicted trade-off between ornament display and immune function. These findings do not support the hypothesis that songbirds with extensive carotenoid-based plumage displays trade off the use of carotenoids for ornamentation versus immune function.
Locating air leaks in manned spacecraft using structure-borne noise (2007)

All manned spacecraft are vulnerable to leaks generated by micrometeorite or debris impacts. Methods for locating such leaks using leak-generated, structure-borne ultrasonic noise are discussed and demonstrated. Cross-correlations of ultrasonic noise waveforms from a leak into vacuum are used to find the location of the leak. Four methods for sensing and processing leak noise have been developed and tested and each of these can be used to reveal the leak location. The methods, based on phased-array, distributed sensor, and dual sensor approaches, utilize the propagation patterns of guided ultrasonic Lamb waves in the spacecraft skin structure to find the source or direction of the leak noise. It is shown that each method can be used to successfully locate the leak to within a few millimeters on a 0.6-m2 aluminum plate. The relative merits of the four methods are discussed.
Monitoring of arterial wall remodelling in atherosclerotic rabbits with a magnetic resonance imaging contrast agent binding to matrix metalloproteinases (2010)

P947-enhanced MRI can distinguish dietary-induced variations in MMP-related enzymatic activity within plaques in an experimental atherosclerotic model, supporting its utility as a clinical imaging tool for in vivo detection of arterial wall remodelling.