gebhart/patrepeval huggingface dataset:
Whole-cell currents activated at nicotinic acetylcholine receptors on ganglion cells isolated from goldfish retina (1993)

We have recorded whole-cell membrane currents in response to exogenously applied acetylcholine (ACh), nicotine, and 1,1 dimethyl-4-phenyl piperazinium iodide on retinal ganglion cells enzymatically dissociated from goldfish retina. Agonist applications induced nicotinic-type responses in a majority of cells when cells were isolated under optimal conditions. Currents were reminiscent of nicotinic-type ganglionic responses. Dose-response measurements of ACh-induced currents indicated an EC50 of 52 microM and a Hill coefficient of 0.6. Currents were selective for Na+ over Cl- and were highly inwardly rectifying. Responses were blocked reversibly by d-tubocurarine, hexamethonium chloride, and N-methyl-D-glucamine. In 50% of the cases, alpha-bungarotoxin reversibly blocked the current induced by ACh application. The blocking action of mecamylamine was irreversible and independent of the presence of agonist but was more effective in the presence of ACh. We conclude that functional nicotinic ACh receptors exist on most goldfish retinal ganglion cells.
Electrical Spectroscopy Studies of Organic/Inorganic Nano Composites (2007)

The electrical conductivity studies of chemically crosslinked nano composite membranes consisting of poly (vinyl alcohol) (PVA) and phosphomolybdic acid (PMA) with different blending composition and crosslinking density has been conducted over a wide frequency regime. The conductivity of the systems has been studied within the temperature range 25 oC ø T oe 100 oC for the hydrated membranes. The proton conductivity of the membranes was generally of the order of 10-3 S/cm. The conductivity of these membranes shows a temperature dependence of Arrhenius type. The activation energies for the membranes were calculated from the conductivity measurements. Both the pristine and hydrated membranes were also characterized by X-Ray diffraction studies to observe the effects of blending and hydration on the crystallinity of the composite membranes. The membranes showed comparable proton conductivity and better resistance to methanol permeability than that of Nafion 112 under the same measurement conditions. These properties make them good candidates as polymer electrolyte membranes for direct methanol fuel cell application.
Photocurable pillar arrays formed via AC- and ultrasound-induced electrohydrodynamic instabilities (2006)

Application of an external electric field across thin polymeric films is known to induce the formation of arrays of cylindrical structures commonly referred to as pillars. Low viscosity photocurable materials have been shown to possess significant advantages over their polymeric counterparts both in terms of a significant reduction in the time of formation, as well as in the elimination of additional processing steps, such as heating and cooling cycles. With proper design, pillar arrays with predetermined diameter, period, location and orientation can theoretically be formed over an entire substrate surface, thus enabling their use in applications such as optics-less patterning, micro-electro-mechanical systems, and micro fluidic devices. In this paper, we present our recent work in using a low viscosity thiolene system to produce pillar arrays and attempts at inducing long range order in the resulting pillar arrays by (1) varying the nature of the external electric field in the form of a sinusoidal AC voltage (instead of the conventional DC voltage) and (2) the use of ultrasonic piezo transducers to generate regular waves in the film with simultaneous application of a potential across the film sample. Our initial results show that although both the AC voltage and the ultrasonic piezo methods are successful in producing pillar arrays, their ordering is short-ranged and does not extend throughout the entire sample area.
In vivo induced allo-reactive natural killer cells (1992)

We have previously shown that rat allo-selective cells of the CD2+CD5- phenotype were generated in Brown Norway (BN) rats after immunization with allogeneic Wistar/Furth (WF) cells, whereas immunization with semi-allogeneic F1 (WF/BN) cells generated CD2+CD5+ effector T cells. We now report that the allo-selective CD2+CD5- lymphocytes lacked expression of intact CD3 complexes and expressed NKR-P1 molecules although lower as compared to classical NK cells, implicating that these lymphocytes constitute a subset of NK cells. The CD5+ T cells were not cytolytically active in BN rats immunized with WF cells indicating an intersubset regulation with mutually exclusive activation of either allo-selective T cells or allo-selective NK cells. Cold target inhibition showed that lysis of both allogeneic target cells and NK-sensitive target cells was mediated by the same NKR-P1 intermediate effector cells. These NK cells lysed WF but not allogeneic Fischer 344 or autologous BN target cells, indicating selective recognition of an allogeneic determinant. Semiallogeneic F1 (WF/BN) target cells were not lysed. Furthermore, target cells from F1 (WF/BN) x WF back-cross hybrids lacking expression of RT1n (self-MHC class I) were susceptible to lysis, whereas back-cross hybrids expressing RT1n were protected from lysis, indicating that self-MHC molecules conferred protection from lysis. These findings implicate the existence of NKR-P1intermediate and NKR-P1high NK cell subsets with different regulation and function in vivo.
Trichorrhexis nodosa. Clinical and investigative studies (1966)

Of 49 patients with trichorrhexis nodosa (TN), 26 had scalp hair involvement, and 20 of these had excessively traumatized their hair. Twenty-three patients had genito-inguinocrural or multiple site involvement and all had pruritus in these areas. In many the TN cleared with less traumatic hair care or with control of the pruritus. Chromatography of urine for argininosuccinic acid and fluorescent acridine orange microscopy and amino acid analysis of hair do not support the theory that this hair abnormality is a metabolic defect. Our clinical findings emphasize the importance of trauma, supported by our recent in vitro reproduction of TN by mechanical stress. The fracturing of hair seen with TN is a common cause of unexplained hair loss.
Cognitive Code-Division Channelization (2011)

We consider the problem of simultaneous power and code-channel allocation for a secondary transmitter/receiver pair coexisting with a primary code-division multiple-access (CDMA) system. Our objective is to find the optimum transmitting power and code sequence of the secondary channel that maximize the signal-to-interference-plus-noise ratio (SINR) at the output of the maximum SINR linear receiver, while at the same time the SINR of all primary channels at the output of their max-SINR receiver is maintained above a certain threshold. This is a non-convex NP-hard optimization problem. We propose a novel feasible suboptimum solution using semidefinite programming. Simulation studies illustrate the theoretical developments.
AI-Ckpt (2013)

With increasing scale and complexity of supercomputing and cloud computing architectures, faults are becoming a frequent occurrence, which makes reliability a difficult challenge. Although for some applications it is enough to restart failed tasks, there is a large class of applications where tasks run for a long time or are tightly coupled, thus making a restart from scratch unfeasible. Checkpoint-Restart (CR), the main method to survive failures for such applications faces additional challenges in this context: not only does it need to minimize the performance overhead on the application due to checkpointing, but it also needs to operate with scarce resources. Given the iterative nature of the targeted applications, we launch the assumption that first-time writes to memory during asynchronous checkpointing generate the same kind of interference as they did in past iterations. Based on this assumption, we propose novel asynchronous checkpointing approach that leverages both current and past access pattern trends in order to optimize the order in which memory pages are flushed to stable storage. Large scale experiments show up to 60% improvement when compared to state-of-art checkpointing approaches, all this achievable with an extra memory requirement of less than 5% of the total application memory.
TM-028. ELECTRIC FIELDS FOR THE TREATMENT OF GLIOBLASTOMAS: A MODELING STUDY (2013)

Oscillating electric fields are being investigated as an adjunct and even an alternative to chemotherapy in the treatment of glioblastoma multiforme. According to in vitro studies, an electric field strength greater than 1 V/cm is necessary to achieve inhibition of tumor growth. Here we used a reali
Preparation and polymerization of vinyl esters of nonhydroxy carnuba wax acids and acrylic esters of carnuba wax alcohols (1965)

Abstract The acrylic esters of carnuba wax alcohols and the vinyl esters of nonhydroxy carnuba wax acids have been synthesized. The acrylic and vinyl esters have been homopolymerized and copolymerized with vinyl chloride. Acrylonitrile–acrylic ester copolymers also have been prepared. The copolymers were quite brittle when molding was attempted.
The visible‐airglow experiment on Atmosphere Explorer (1973)

The visible‐airglow experiment is an airglow photometer designed to measure various thermospheric emission features during the day and night both at low latitudes and in auroras. The photometer has two distinct optical channels, a high‐sensitivity channel with a large field of view and a low‐sensitivity channel with a narrow field of view to resolve small features. The system is protected by a combination attenuator and cathode back‐biasing scheme which allows measurements of maximum sensitivity within a fraction of a second of viewing the sun. This experiment will be a part of the scientific payload on all three Atmosphere Explorer missions.
Spectral coherent emission of thermal radiation in the far-field from a truncated resonator (2012)

The spectral radiative properties of coherent thermal emission in the mid- and far-IR from two metal-semiconductor resonating structures were demonstrated experimentally. Using an efficient implementation of Rigorous Coupled-Wave Analysis, a truncated resonator was designed to selectively emit at mid-IR and far-IR wavelengths. A High Impulse Power Magnetron Sputtering deposition technique was used to fabricate two Ag-Ge-Ag resonating structures with layer thicknesses of 6-240-160 nm for one sample and 6-700-200 nm for the other. Reflectance measurements demonstrated spectrally selective absorption at the designed mid- and far-IR wavelengths whose general behavior was largely unaffected by a wide range of incident angles. Further, radiance measurements were taken at various high temperatures, up to 601 K, where spectrally selective emission was achieved through wave interference effects due to thermally excited surface waves. From these radiance measurements, spectral emittance was directly derived and compared to the emittance inferred from reflectance measurements. It was established that inferring emittance through Kirchhoff’s law can help to approximate the expected emission from a structure, but it is not an exact method of determining the actual emittance of a thermal source at higher temperatures due to the temperature dependence of material parameters.
Claisen and Aldol Condensations of α-Picoline and Quinaldine with Ethyl Oxalate by Alkali Amides<sup>1</sup> (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTClaisen and Aldol Condensations of α-Picoline and Quinaldine with Ethyl Oxalate by Alkali Amides1Charles R. Hauser and Wilbert J. HumphlettCite this: J. Am. Chem. Soc. 1950, 72, 8, 3805–3806Publication Date (Print):August 1, 1950Publication History Published online1 May 2002Published inissue 1 August 1950https://doi.org/10.1021/ja01164a510RIGHTS & PERMISSIONSArticle Views82Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (270 KB) Get e-Alerts Get e-Alerts
Skin cancer: non-melanoma (2016)

Non-melanoma skin cancer (NMSC) is the most common malignancy in fair-skinned populations. In Australia, NMSC is four times as common as all other cancers combined, with an incidence of ~1000 per 100 000 person-years. The incidence of NMSC has been gradually rising among Caucasian/white populations over the last few decades. The vast majority of NMSCs are basal cell carcinomas (BCCs), which rarely metastasize, or squamous cell carcinomas (SCCs), which do have metastatic potential, especially in immune-suppressed individuals. Because of their high frequency in the general population, and particularly in older people, NMSCs are likely to occur in many general oncology patients. Skin cancer risk can be additionally increased in oncology patients as a result of disease-induced immune suppression (e.g., non-Hodgkin’s lymphoma) or by a range of cancer treatments including iatrogenic immune suppression, radiation therapy arsenic, and BRAF inhibitors (if not given with a MEK inhibitor). In this chapter the aetiology, pathology, prognosis, and management of NMSCs are discussed.
Disposal of NORM-contaminated oil field wastes in Salt Caverns. (1998)

In 1995, the U.S. Department of Energy (DOE), Office of Fossil Energy, asked Argonne National Laboratory (Argonne) to conduct a preliminary technical and legal evaluation of disposing of nonhazardous oil field waste (NOW) into salt caverns. That study concluded that disposal of NOW into salt caverns is feasible and legal. If caverns are sited and designed well, operated carefully, closed properly, and monitored routinely, they can be a suitable means of disposing of NOW (Veil et al. 1996). Considering these findings and the increased U.S. interest in using salt caverns for NOW disposal, the Office of Fossil Energy asked Argonne to conduct further research on the cost of cavern disposal compared with the cost of more traditional NOW disposal methods and on preliminary identification and investigation of the risks associated with such disposal. The cost study (Veil 1997) found that disposal costs at the four permitted disposal caverns in the United States were comparable to or lower than the costs of other disposal facilities in the same geographic area. The risk study (Tomasko et al. 1997) estimated that both cancer and noncancer human health risks from drinking water that had been contaminated by releases of cavern contents were significantly lower than the accepted risk thresholds. Since 1992, DOE has funded Argonne to conduct a series of studies evaluating issues related to management and disposal of oil field wastes contaminated with naturally occurring radioactive material (NORM). Included among these studies were radiological dose assessments of several different NORM disposal options (Smith et al. 1996). In 1997, DOE asked Argonne to conduct additional analyses on waste disposal in salt caverns, except that this time the wastes to be evaluated would be those types of oil field wastes that are contaminated by NORM. This report describes these analyses. Throughout the remainder of this report, the term ''NORM waste'' is used to mean ''oil field waste contaminated by NORM''.
Randomized gossip algorithms for maintaining a distributed bulletin board with guaranteed age properties (2009)

Abstract Scalable computer systems, including clusters and multi‐cluster grids, require routine exchange of information about the state of system‐wide resources among their nodes. Gossip‐based algorithms are popular for providing such information services due to their simplicity, fault tolerance and low communication overhead. This paper presents a randomized gossip algorithm for maintaining a distributed bulletin board among the nodes of a scalable computer system. In this algorithm each node routinely disseminates its most recently acquired information while maintaining a snapshot of the other nodes' states. The paper provides analytical approximations for the expected average age, the age distribution and the expected maximal age for the acquired information at each node. We confirm our results by measurements of the performance of the algorithm on a multi‐cluster campus grid with 256 nodes and by simulations of configurations with up to 2048 nodes. The paper then presents practical enhancements of the algorithm, which makes it more suitable for a real system. Such enhancements include using fixed‐size messages, reducing the number of messages sent to inactive nodes and supporting urgent information. The enhanced algorithm guarantees the age properties of the information at each node in the configurations with an arbitrary number of inactive nodes. It is being used in our campus grid for resource discovery, for dynamic assignment of processes to the best available nodes, for load‐balancing and for on‐line monitoring. Copyright © 2009 John Wiley & Sons, Ltd.
Über einige reaktionsfähige Fluor‐Verbindungen der aromatischen Reihe (1953)

Abstract Es wurden aromatische Fluor‐Derivate der Diphenyl‐ und Diphenylsulfon‐Reihe dargestellt, in welchen die Fluoratome durch zwei geeignet eingeführte Nitrogruppen oder eine Nitrogruppe und eine Sulfogruppe derart aktiviert sind, daß sie mit Aminen, Aminosäuren, Phenolen und Proteinen zu reagieren vermögen.
Personalized Healthcare communication in Internet of Things (2008)

Personalized healthcare is a challenge because supports the sustainability of care. Internet of Things is a paradigm promising to manage the digital identity, so the personalization of care services. Different equipment is used in extra-wall healthcare and assistive services, requiring different sorts of objects to communicate and to make the ubiquitous system-of-system. Extended entities and mixed roles are becoming inter-operable. We present how adaptative care might exploit the broadband communication over powerline, with the link to the digital energy. 1.
In vivo histopathological assessment of the muscularis propria in achalasia by using endocytoscopy (with video) (2014)

In a clinical setting, real-time assessment of the MP using EC is feasible. This technique may play an important role in determining the pathology of achalasia and other diseases that affect gastrointestinal function.
Fiber Optic Sensing Systems Using High Frequency Resonant Sensing Heads With Intensity Sensors (1989)

Optical fibers have an inherent capability of transmitting high bandwidth analog and digital signals. To apply this property of fiber optics to remote sensing, special sensing heads as well as signal processing electronics have to be developed. In systems employing intensity modulating sensors, there is also a need for a referencing technique to compensate for changes in the transmission of the connecting fibers and light source intensity. This paper discusses fiber optic sensing systems using intensity sensors incorporated in sensing heads of a special configuration. Different modes of operation as well as resonant conditions are explained. Theoretical and experimental analyses are also given.
Insulin receptor kinase activity in muscles and white adipose tissue during course of VMH obesity (1992)

Early after lesion of the ventromedial hypothalamus nuclei (VMH), insulin-induced glucose utilization is increased in white adipose tissue (WAT), whereas oxidative and glycolytic muscles are, respectively, normoresponsive or resistant to insulin. Five weeks later, all of the muscles are resistant, whereas WAT returns to normal responsiveness. The aim of this study was to characterize the insulin receptor kinase activity in WAT and muscles 1 and 6 wk after lesion. The number and affinity of insulin receptors were not modified in any of the tissues studied. Autophosphorylation and phosphorylation of an exogenous substrate were similar in oxidative and glycolytic muscles of VMH and control rats both 1 and 6 wk after the lesion. Insulin receptors from WAT of 1-wk VMH rats exhibited a 2.5-fold increase in insulin-stimulated autophosphorylation and phosphorylation. Six weeks after the lesion, both autophosphorylation and phosphorylation returned to normal values. This suggests that insulin receptor tyrosine kinase activity does not play a significant role in the insulin resistance of skeletal muscles but has a crucial role in mediating the variations of insulin action on WAT observed during the development of VMH obesity.
Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways. (1994)

We have examined the mucosal changes occurring in bronchial biopsies from six atopic asthmatics 5-6 h after local endobronchial allergen challenge and compared them with biopsies from saline-challenged segments from the same subjects at the same time point. All the subjects developed localized bronchoconstriction in the allergen-challenged segment and had a decrease in forced expiratory volume in 1 s (FEV1) (P < 0.01) and a decrease in their methacholine provocative concentration of agonist required to reduce FEV1 from baseline by 20% (P < 0.05) 24 h postchallenge. At 6 h we observed an increase in neutrophils (P = 0.03), eosinophils (P = 0.025), mast cells (P = 0.03), and CD3+ lymphocytes (P = 0.025), but not in CD4+ or CD8+ lymphocyte counts. We also detected an increase in endothelial intercellular adhesion molecule type 1 (P < 0.05) and E-selectin (P < 0.005), but not vascular cell adhesion molecule type 1 expression with a correlative increase in submucosal and epithelial LFA+ leucocytes (P < 0.01). Thus, in sensitized asthmatics, local endobronchial allergen instillation leads to an increased inflammatory cell infiltrate of the airway mucosa that involves upregulation of specific adhesion molecules expressed on the microvasculature.