gebhart/patrepeval huggingface dataset:
Retinol saturase coordinates liver metabolism by regulating ChREBP activity (2017)

The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that the oxidoreductase retinol saturase (RetSat) is involved in the development of fatty liver. Hepatic RetSat expression correlates with steatosis and serum triglycerides (TGs) in humans. Liver-specific depletion of RetSat in dietary obese mice lowers hepatic and circulating TGs and normalizes hyperglycemia. Mechanistically, RetSat depletion reduces the activity of carbohydrate response element binding protein (ChREBP), a cellular hexose-phosphate sensor and inducer of lipogenesis. Defects upon RetSat depletion are rescued by ectopic expression of ChREBP but not by its putative enzymatic product 13,14-dihydroretinol, suggesting that RetSat affects hepatic glucose sensing independent of retinol conversion. Thus, RetSat is a critical regulator of liver metabolism functioning upstream of ChREBP. Pharmacological inhibition of liver RetSat may represent a therapeutic approach for steatosis.Fatty liver is one of the major features of metabolic syndrome and its development is associated with deregulation of systemic lipid and glucose homeostasis. Here Heidenreich et al. show that retinol saturase is implicated in hepatic lipid metabolism by regulating the activity of the transcription factor ChREBP.
Toxicity Assessment of Environmental Complex Mixtures in and around Roadways (2002)

The aim of this study was to evaluate the toxic effect of heavy metals to bacteria and plant. A spiderwort (Tradescantis clone BNL 4430) and coliform bacteria (Esherichea coli strain MV1184 and Comamonas testosteroni strain TK102) were used in this study. The growth of C. testosteroni strain TK102 was inhibited by copper, lead, and cadmium. Cadmium shows the strongest growth inhibition among these three metals. In an assay of Tradescantis, zinc reduced the amount of chlorophiles in leaves. Copper inhibited flowering and had a fatal effect on Tradescantia.
Trauma Centers in the United States (1995)

The study provides structural and organizational profiles of trauma centers that should help trauma system planners identify strong candidates for trauma center designation.
Reflectivity spectra of Eu rich EuO near the absorption edge (1979)

The reflectivity spectra at near normal incidence in the spectral range 1.5 μm to 4 μm of EuO single crystals slightly rich in Eu but almost stoichiometric have been measured in the temperature range 4.2 to 300 K, using the Voigt configuration. Two dips are observed at 1.85 and 2.20 μm in fairly good agreement with the location of the two absorption peaks observed in similar materials. These peaks are ascribed in the literature either to optical transitions of an electron bound to an oxygen vacancy or to transitions into F centres formed at the vacancies. Our measurements show a very small temperature dependence of the energy position of the dips in the whole range [4.2-300 K] and a small intensity of the dips, which is in favour of the first interpretation when the material is an insulator, and of an alternative one in the metallic configuration, i.e. an interband transition between up and down spin subbands. At 4.2 K, two extra dips appear at 1.74 and 2 μm. The magnetic field up to 30 kG does not affect the energy position of the different dips, but greatly affects their shape.
An inquiry into the lunar interior: A nonlinear inversion of the Apollo lunar seismic data (2002)

This study discusses in detail the inversion of the Apollo lunar seismic data and the question of how to analyze the results. The well‐known problem of estimating structural parameters (seismic velocities) and other parameters crucial to an understanding of a planetary body from a set of arrival times is strongly nonlinear. Here we consider this problem from the point of view of Bayesian statistics using a Markov chain Monte Carlo method. Generally, the results seem to indicate a somewhat thinner crust with a thickness around 45 km as well as a more detailed lunar velocity structure, especially in the middle mantle, than obtained in earlier studies. Concerning the moonquake locations, the shallow moonquakes are found in the depth range 50–220 km, and the majority of deep moonquakes are concentrated in the depth range 850–1000 km, with what seems to be an apparently rather sharp lower boundary. In wanting to further analyze the outcome of the inversion for specific features in a statistical fashion, we have used credible intervals, two‐dimensional marginals, and Bayesian hypothesis testing. Using this form of hypothesis testing, we are able to decide between the relative importance of any two hypotheses given data, prior information, and the physical laws that govern the relationship between model and data, such as having to decide between a thin crust of 45 km and a thick crust as implied by the generally assumed value of 60 km. We obtain a Bayes factor of 4.2, implying that a thinner crust is strongly favored.
Load shedding techniques for data stream management systems (2007)

In recent years, we have witnessed the emergence of a new class of applications that must deal with large volumes of streaming data. Examples include financial data analysis on feeds of stock tickers, sensor-based environmental monitoring, and network traffic monitoring. Traditional database management systems (DBMS) which are very good at managing large volumes of stored data, fall short in serving this new class of applications, which require low-latency processing on live data from push-based sources. Aurora is a data stream management system (DSMS) that has been developed to meet these needs. 
A DSMS such as Aurora may be subject to higher input rates than its resources can handle. When input rates exceed system capacity, the system will become overloaded and Quality of Service (QoS) at system outputs will fall below acceptable levels. Under these conditions, the system will shed load by selectively dropping tuples, thus degrading the answer, in order to improve the observed latency of the results. 
In this dissertation, we first define the load shedding problem in data stream management systems and provide a general solution framework which handles the overload problem in a light-weight manner, while minimizing the loss in result accuracy. Then we present additional techniques on top of this basic framework to handle windowed aggregation queries in a way that preserves the subset result guarantee. 
Due to the distributed nature of stream-based data sources as well as the need for better scalability and fault tolerance, we have recently extended Aurora into Borealis—a larger-scale system that can operate in distributed environments. In such an environment, the load shedding problem involves simultaneously removing excess load from multiple overloaded nodes in a scalable fashion. In the final part of this thesis, we investigate this distributed load shedding problem, and provide several alternative solutions to extend our earlier framework in Aurora to the distributed setting of the Borealis system.
Determination of the partial molar volume of SiO2 in silicate liquids at elevated pressures and temperatures: a new experimental approach (1998)

This study presents a new approach for determining the partial molar volume and its pressure derivative for a silicate liquid component through an experimental determination of the isothermal pressure dependence of the solubility in the liquid of a crystalline phase having the composition of the component. Because this approach allows the determination of partial molar volumes of liquid components at elevated pressure, it has the potential to detect pressure-induced structural changes associated with particular components in silicate liquid through their influence on partial molar volumes. To illustrate the approach, an experimental determination of the solubility of quartz in a rhyolitic liquid was used to determine the partial molar volume of SiO2 at pressures up to 35 kbar and a temperature of 1350°C. The 1 bar partial molar volume for SiO2 determined in this way, 2.635 ± 0.009 J/bar, is slightly smaller than the 2.690 ± 0.006 J/bar determined by Lange and Carmichael (1987) (all uncertainties are 1σ). The isothermal pressure dependence of the partial molar volume of SiO2 at 10 to 35 kbar (−8.69 × 10−6 ± 6.1 × 10−7 J/bar2) is approximately one-half of the value determined by Kress and Carmichael (1991) at 1 bar (−1.96 × 10−5 ± 0.2 × 10−6 J/bar2). Our high pressure determination can be reconciled with the existing 1 bar volume and compressibility data if the isothermal pressure dependence of the partial molar volume of SiO2 in silicate liquids decreases rapidly between 1 bar and 10 kbar, then remains approximately constant to at least 35 kbar.
Collagen formation in extracellular matrix of transplants of human transformed keratinocyte cell lines. (2002)

The development of mesenchyme was directly related to duration of growth of transplants and degree of malignancy; mesenchyme organization was inversely related to differentiation of the epithelial cells. The results showed the usefulness of the transplant model in studies on cell and tissue growth and organization.
Quantitation of homogeneous and inhomogeneous broadening mechanisms in <i>t</i> <i>r</i> <i>a</i> <i>n</i> <i>s</i>-stilbene using absolute resonance Raman intensities (1985)

The sensitivity of resonance Raman cross sections to the excited state homogeneous width is exploited to separate the homogeneous and inhomogeneous contributions to the optical absorption linewidth in trans-stilbene. Absolute Raman cross sections have been measured using excitation at 356, 299, 282, and 266 nm, and calculations have been performed to model the intensities of the eleven strongly Raman-active modes as well as the absorption spectrum. A simple analysis neglecting explicit temperature effects requires a homogeneous Lorentzian linewidth (Γ) of 310 cm−1 and an inhomogeneous Gaussian distribution of zero–zero energies with a standard deviation (θ) of 500 cm−1. Consideration of thermal excitation in the lowest-frequency single-bond torsional mode significantly improves the fit to the experimental absorption by broadening the spectrum asymmetrically to higher energies, while allowing Γ and θ to be reduced to 120 and 450 cm−1, respectively. The spectral broadening generated by thermal excitation of ground-state torsional modes thus contributes significantly to the homogeneous linewidth in trans-stilbene. The relatively large effective homogeneous width at room temperature is consistent with the low Raman intensity in the ∼200 cm−1 C=C–φ bend compared with the prominence of this vibration in resolved low-temperature electronic spectra.
Effects of Increasing Insulin Secretion on Acute Postexercise Blood Glucose Disposal (2006)

The combined ingestion of a protein hydrolysate and/or free leucine with carbohydrate (0.8 g.kg.h) substantially augments insulin secretion, but does not affect plasma glucose disposal during the first 3.5 h of postexercise recovery in trained athletes.
Both Genome Segments Contribute to the Pathogenicity of Very Virulent Infectious Bursal Disease Virus (2012)

Infectious bursal disease virus (IBDV) causes an economically significant disease of chickens worldwide. Very virulent IBDV (vvIBDV) strains have emerged and induce as much as 60% mortality. The molecular basis for vvIBDV pathogenicity is not understood, and the relative contributions of the two genome segments, A and B, to this phenomenon are not known. Isolate 94432 has been shown previously to be genetically related to vvIBDVs but exhibits atypical antigenicity and does not cause mortality. Here the full-length genome of 94432 was determined, and a reverse genetics system was established. The molecular clone was rescued and exhibited the same antigenicity and reduced pathogenicity as isolate 94432. Genetically modified viruses derived from 94432, whose vvIBDV consensus nucleotide sequence was restored in segment A and/or B, were produced, and their pathogenicity was assessed in specific-pathogen-free chickens. We found that a valine (position 321) that modifies the most exposed part of the capsid protein VP2 critically modified the antigenicity and partially reduced the pathogenicity of 94432. However, a threonine (position 276) located in the finger domain of the virus polymerase (VP1) contributed even more significantly to attenuation. This threonine is partially exposed in a hydrophobic groove on the VP1 surface, suggesting possible interactions between VP1 and another, as yet unidentified molecule at this amino acid position. The restored vvIBDV-like pathogenicity was associated with increased replication and lesions in the thymus and spleen. These results demonstrate that both genome segments influence vvIBDV pathogenicity and may provide new targets for the attenuation of vvIBDVs.
The Nature of the Mohorovicic Discontinuity (1989)

Brachiopods are (perhaps all too) familiar to any geology student who has taken an invertebrate paleontology course; they may well be less familiar to biology students. Even though brachiopods are among the most significant components of the marine fossil ...Read More
Numerical Modeling of the Water Flow Around Ship Hulls (2001)

A numerical method based on potential-flow theory using Rankine sources has been developed for the prediction of the flow past ship hulls. For purposes of validation, the method has been applied initially to the known analytical solution of flow past a sphere submerged in an infinite fluid. It was confirmed that a significant improvement could be obtained over the original method of Hess and Smith by projecting the collocation points back onto the actual surface of the sphere with additional smaller gains using submergence of the panels below the body surface. The method was then extended by the introduction of a free-water surface boundary condition and used to calculate the wave resistance of a Wigley hull for higher Froude numbers, up to 1.0. Raven's correction to Dawson's original formulation was included and evaluated. It was found that the correction made only a small difference to the calculated wave resistance. The results of the present work were seen to agree closely with experimental data for residual resistance up to a Froude number of approximately 0.65 but then give slightly lower values for higher Froude numbers. The difference was attributed primarily to the method of deducing the experimental values of the residual resistance from the total resistance where the frictional resistance had been based on the static wetted surface area.
Psychalcoolique (2009)

Article disponible en ligne l'adresse https://shs.cairn.info/revue-la-revue-lacanienne-2009-3-page-17?lang=fr Dcouvrir le sommaire de ce numro, suivre la revue par email, s'abonner... Scannez ce QR Code pour accder la page de ce numro sur Cairn.info. Distribution lectronique Cairn.info pour rs.Vous avez l'autorisation de reproduire cet article dans les limites des conditions d'utilisation de Cairn.infoou, le cas chant, des conditions gnrales de la licence souscrite par votre tablissement.Dtails et conditions sur cairn.info/copyright.Sauf dispositions lgales contraires, les usages numriques des fins pdagogiques des prsentes ressources sont soumises l'autorisation de l'diteur ou, le cas chant, de l'organisme de gestion collective habilit cet effet.Il en est ainsi notamment en France avec le CFC qui est l'organisme agr en la matire.
Measurement of Sine-Wave Response of a Photographic Emulsion* (1959)

A method for experimentally determining the sine-wave response of a photographic emulsion is described. It consists in determining the sine-wave response of a lens, using the lens to photograph a sinusoidal test object on the emulsion under test, determining the response of the lens-emulsion combination, and dividing out the response of the lens. Since sine-wave response is defined in terms of relative exposure in the emulsion, it should be substantially independent of development conditions and the exposure level when adjacency effects are absent. This expectation has been confirmed experimentally. It is also shown that the sine-wave response of a lens and the response of an emulsion can be combined to predict the characteristics of the lens-emulsion combination.
A one-step co-condensation method for the synthesis of well-defined functionalized mesoporous SBA-15 using trimethallylsilanes as organosilane sources (2015)

A new method for the preparation of well-defined functionalized mesoporous SBA-15 has been developed by a one-step co-condensation method using trimethallylsilanes as organosilane sources. This new method enables the incorporation of various bulky organic functional groups with long alkyl chain tethers into the mesoporous silica network.
Robust H(infinity) control design for the Space Station with structured parameter uncertainty (1990)

A robust H-infinity control design methodology and its application to a Space Station attitude and momentum control problem are presented. This new approach incorporates nonlinear multi-parameter variations in the state-space formulation of H-infinity control theory. An application of this robust H-infinity control synthesis technique to the Space Station control problem yields a remarkable result in stability robustness with respect to the moments-of-inertia variation of about 73% in one of the structured uncertainty directions. The performance and stability of this new robust H-infinity controller for the Space Station are compared to those of other controllers designed using a standard linear-quadratic-regulator synthesis technique.
<i>Retracted on March 1, 2022</i> : Practical Secure OMP Computation and Its Application to Image Modeling (2018)

In this paper, we propose the secure computation of sparse coding based on a random unitary transform. Cloud computing is spreading to many application fields including services that use sparse coding. This situation raises many new privacy concerns. The proposed scheme provides a practical Orthogonal Matching Pursuit (OMP) algorithm that allows computation on encrypted signals. We prove, theoretically, that the proposal has exactly the same sparse coefficient estimation performance as the unencrypted variant of the OMP algorithm. We apply it to image modeling based on an image patch model. Finally, we demonstrate its performance on synthetic data and natural images.
The Difference of Executive Function Between the Older Adults with Different Levels of Physical Activity (2010)

The effects of physical activity in promoting cognitive function have been recognized in many studies. However, there are many inconsistent results in the previous literatures owing to different cognitive tests. PURPOSE: The present study was designed to selectively examine behavioral indices of older adults in executive function related to non-delayed and delayed matching-to-sample recall capabilities by evaluating the influence of different levels of physical activity on task performance during two working memory tasks. METHODS: Twelve sedentary older adults (six women, six men, age range 65-69, mean 67.5 years) recruited from two communities and twelve age- and sex-matched older adults recruited from two exercise clubs participated in the experiment. Each one was screened using Mini-Mental State Examination and seven-day physical activity recall questionnaire, and then categorized into exercise or control group. All subjects with normal cognitive function and normal or corrected-to-normal vision acuity performed two working memory tasks simultaneously. The behavioral measures of reaction time and accuracy were measured during the heterogeneous conditions of the non-delayed and delayed working memory tasks. An analysis of variance, with group and conditions as the main factors and the mean RT as the dependent variable, was conducted to determine whether a significant difference existed between groups. Statistical assessment of accuracy data was calculated by the Mann-Whitney non-parametric test, as the values were not normally distributed. A significance criterion of p<.05 was established for all the reported results. RESULTS: The exercise group had significantly better behavioral performance on the executive function when performing the cognitive tests. Namely, reaction time was shorter in the two working memory tasks in exercise group as compared to control group (F 1,22 = 11.98, p = 0.002, partial h2 = 0.35). In addition, older adults in exercise group performed significantly better on accurate rates, as compared to controls (Mann-Whitney non-parametric test, p = 0.002). CONCLUSION: Our findings suggested that, when performing working memory tasks, the older adults with high physical activity have better executive function than the older ones with low physical activity.
Recent Advances in Applications of Encapsulation Technology for the Bioprotection of Phytonutrients in Complex Food Systems (2014)

Encapsulation can be used for many applications in food technology, including stabilizing core materials, controlling oxidative reactions, providing sustained or controlled release, masking flavours, colours or odours, extending shelf life and protecting components against nutritional loss. Brief descriptions of the various methods of encapsulation and the release mechanisms of the encapsulated core materials from the beads, microcapsules, microspheres, nanocapsules, nanospehres and emulsions are provided. Microcapsules and microspheres can be engineered to gradually release their active ingredients. As the wall matrix of microcapsules is designed to limit mass transfer between the core and the environment, it is important that core materials are non-porous to liquids and gases. There are three primary mechanisms by which active agents can be released from a delivery system: diffusion, degradation and swelling followed by diffusion. The encapsulation method should take into account potential interactions of the coating with other components within the body.
STRESS WAVE INSPECTION OF BRIDGE TIMBERS AND DECKING. FINAL REPORT (1987)

This report is designed to provide information to guide inspectors of wood highway structures in the use of stress wave inspection technology. It explains the methods and instruments used to measure the velocity of stress waves (sound) in wood. The characteristic behavior of sound waves in wood of various species, moisture content, preservative treatment and infection by wood destroying organisms is described. The important effects of the anatomy of wood and the orientation of grain and annual rings to the wave path are discussed to aid in the interpretation of measurements. Characteristics of the instrumentation essential to its calibration are explained and instruction is provided in the appropriate use of these tools. This report has been written to serve as a manual for on site stress wave inspection of the kind of wood structures found in highway systems. It is a compendium of experience in the field inspection of many wood buildings and highway bridges. Original research conducted to fill in voids in the published studies, is described in the Appendices.