gebhart/patrepeval huggingface dataset:
Decreased bacteria activity on Si3N4 surfaces compared with PEEK or titanium (2012)

A significant need exists for orthopedic implants that can intrinsically resist bacterial colonization. In this study, three biomaterials that are used in spinal implants--titanium (Ti), polyether-ether-ketone (PEEK), and silicon nitride (Si₃N₄)--were tested to understand their respective susceptibility to bacterial infection with Staphylococcus epidermidis, Staphlococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterococcus. Specifically, the surface chemistry, wettability, and nanostructured topography of respective biomaterials, and the effects on bacterial biofilm formation, colonization, and growth were investigated. Ti and PEEK were received with as-machined surfaces; both materials are hydrophobic, with net negative surface charges. Two surface finishes of Si₃N₄ were examined: as-fired and polished. In contrast to Ti and PEEK, the surface of Si₃N₄ is hydrophilic, with a net positive charge. A decreased biofilm formation was found, as well as fewer live bacteria on both the as-fired and polished Si₃N₄. These differences may reflect differential surface chemistry and surface nanostructure properties between the biomaterials tested. Because protein adsorption on material surfaces affects bacterial adhesion, the adsorption of fibronectin, vitronectin, and laminin on Ti, PEEK, and Si₃N₄ were also examined. Significantly greater amounts of these proteins adhered to Si₃N₄ than to Ti or PEEK. The findings of this study suggest that surface properties of biomaterials lead to differential adsorption of physiologic proteins, and that this phenomenon could explain the observed in-vitro differences in bacterial affinity for the respective biomaterials. Intrinsic biomaterial properties as they relate to resistance to bacterial colonization may reflect a novel strategy toward designing future orthopedic implants.
Rules for PP2A-controlled phosphosignalling and drug responses (2018)

Abstract Systemic understanding of protein phosphatase 2A (PP2A)-regulated cellular processes is still at infancy. Here, we present mass-spectrometry analysis of phospho-targets (dephosphorylome) regulated by PP2A modulation. In addition to PP2A-regulated processes and targets, the data reveal important general concepts and rules related to PP2A-mediated phosphoregulation. These include the unidirectionality paradigm of regulation of phosphorylation, and differential spatial distribution of kinase-and phosphatase-dominated phosphotargets. Data also present first systemic analysis of targets of PP2A-modulating oncoproteins, CIP2A, PME-1, and SET; including targets via which PP2A may coordinately regulate activities of cancer drivers and tumor suppressors such as MYC or TP53. To validate functional utility of this dataset, PP2A dephosphorylome activity was correlated with cancer cell responses to over 300 drugs. Notably, we find that cancer therapy responses can be broadly classified based on PP2A dephosphorylome activity, both in quantitative and qualitative manner. In summary, our data characterize rules by which PP2A coordinate cancer cell phosphosignaling and drug responses. The results also may also direct the use of emerging pharmacological approaches for PP2A activity modulation in human diseases.
Studies on antitumor activities of Basidiomycetes (1976)

雌雄のマウスにSascoma 180, Ehrlich carcinoma, Pulmonay tumor 7423, NF-sarcomaなどの固型種瘍を移植すると,雌雄間の腫瘍の消長には顕著な差が認められ,雌には腫瘍の自然退縮が発現することが多かった.またprogesterone, estrogeneなどでfeminizedされた雄マウスでも同様の成績であったが, Shionogi carcinoma 42とEhrlich腹水腫瘍の増殖には性差の影響は示されなかった.固型腫瘍に対する多糖の抗腫瘍性に対しても,雌マウスに高い効果が見られたが,腹水型ではほとんど有意差は認められなかった.また担子菌由来の多糖であるATSO, Coriolan, P. GU-1などは固型腫瘍に有効であるが,海藻由来の多糖であるSPMは腹水型腫瘍に延命治癒を示し,この腫瘍より回復した動物は腹水腫瘍の再移植を拒絶するとともにSarcoma 180, Shionogi carcinoma 42, NF-sarcoma, Ehrlich固型腫瘍などの腫瘍にも抵抗性を示した.また腫瘍を移植する前にX線照射Ehrlich腹水腫瘍細胞と,多糖を併用すると,多糖の抗腫瘍効果は顕著に促進された.これには多糖のadjuvant活性,免疫促進作用などの生物活性が関与していることが推定された.これらの作用はいずれも雌に強く発現した.
A comparative study of Cd‐ and Zn‐compound buffer layers on Cu(In<sub>1−<i>x</i></sub>,Ga<i><sub>x</sub></i>)(S<i><sub>y</sub></i>,Se<sub>1−<i>y</i></sub>)<sub>2</sub> thin film solar cells (2015)

Abstract This paper reports a comparative study of Cu(In,Ga)(S,Se) 2 (CIGSSe) thin‐film solar cells with CBD‐CdS, CBD‐ZnS(O,OH) and ALD‐Zn(O,S) buffer layers. Each buffer layer was deposited on CIGSSe absorber layers which were prepared by sulfurization after selenization (SAS) process by Solar Frontier K. K. Cell efficiencies of CBD‐CdS/CIGSSe, CBD‐ZnS(O,OH)/CIGSSe and ALD‐Zn(O,S)/CIGSSe solar cells exceeded 18%, for a cell area of 0.5 cm 2 . The solar cells underwent a heat‐light soaking (HLS) post‐treatment at 170 °C under one‐sun illumination in the air; among the three condtions, the ALD‐Zn(O,S)/CIGSSe solar cells showed the highest cell efficiency of 19.78% with the highest open‐circuit voltage of 0.718 V. Admittance spectroscopy measurements showed a shift of the N 1 defect's energy position toward shallower energy positions for ALD‐Zn(O,S)/CIGSSe solar cells after HLS post‐treatment, which is in good agreement with their higher open‐circuit voltage and smaller interface recombination than that of CBD‐ZnS(O,OH)/CIGSSe solar cells. Copyright © 2015 John Wiley & Sons, Ltd.
CORRELATIONS DES DÉPLACEMENTS CHIMIQUES EN RMN 13C DE COMPOSÉS CARBONYLES, THIOCARBONYLES ET SELENOCARBONYLES (1998)

(1998). Correlations Des DéPlacements Chimiques En Rmn 13C De ComposéS Carbonyles, Thiocarbonyles Et Selenocarbonyles. Phosphorus, Sulfur, and Silicon and the Related Elements: Vol. 134, No. 1, pp. 295-305.
Intra-session absolute and relative reliability of pressure pain thresholds in the low back region of vine-workers: effect of the number of trials (2016)

The assessment of PPTs of the lower back among vine-workers was found to have excellent relative and absolute reliability. Moreover, reliable measurements can be equally achieved when using the mean of three PPT measurement or with the first one.
Production d'électricité éolienne : de la caractérisation du gisement éolien aux technologies d'aérogénérateurs (2016)

Article de vulgarisation pour l'Encyclopédie de l'énergie (en ligne)
INDEPENDENT EVALUATION OF THE LITHOGOLD LG-380 LITHOTRIPTER: IN VITRO ACOUSTIC CHARACTERISTICS AND ASSESSMENT OF RENAL INJURY IN THE PIG MODEL (2009)

We present the first randomized clinical study using BackStop™, a novel reverse thermosensitive water-soluble polymer that is dispensed above the stone(s) and temporarily occludes the ureter to prevent retropulsion of stone fragments during ureteroscopic lithotripsy. After fragmentation is completed and concretions are extracted, conventional irrigation with saline dissolves the polymer, which is then flushed out.A total of 68 subjects with a single stone in the proximal ureter and an indication for ureteroscopic lithotripsy were enrolled in this prospective, randomized, single-blind, controlled, multisite clinical study. Each subject was randomly assigned to the BackStop group (34) or the control group (34 with no antiretropulsion device). For subjects in the experimental group BackStop was dispensed into the ureter above the stone using a 3Fr or 5Fr catheter. Ureteroscopic lithotripsy was performed in all subjects using pneumatic or laser energy. Measured end points included the retropulsion rate, the need for subsequent procedures, the stone-free rate at followup, the occurrence of adverse events and ureteral occlusion, if any, and post-stone fragmentation and extraction.Subjects randomized to the BackStop group experienced a statistically significant (p = 0.0002) lower rate of retropulsion (8.8%, 3 of 34) vs the control group (52.9%, 18/34). There were no adverse events in the BackStop group and BackStop was successfully dissolved in every subject, resulting in a patent ureter.BackStop appears to be a novel, safe and effective means of preventing stone fragment retropulsion during ureteroscopic lithotripsy for the management of ureteral stones.
Dusky Sap Beetles (Coleoptera: Nitidulidae) and Other Kernel Damaging Insects in Bt and Non-Bt Sweet Corn in Illinois (2000)

Bt and non-Bt sweet corn hybrids (Rogers 'Empire' Bt and non-Bt, respectively) were compared for distribution of kernel damaging insect pests in central Illinois in 1998 and 1999. The occurrence and damage by caterpillars [primarily Helicoverpa zea (Boddie)] were reduced by at least 80% in each year for the Bt compared with the non-Bt hybrid. However, the incidence of sap beetle adults (primarily Carpophilus lugubris Murray) was higher, and larvae, lower for the Bt versus non-Bt in 1999. The incidence of ears with more than five kernels damaged by sap beetles was higher for the Bt compared with non-Bt hybrid in 1998 (13.8 versus 5.5%), but nearly equivalent in 1999 (15.3 versus 15.1%, respectively). Distribution of predators on plants (primarily Coccinelidae) and harvested ears (primarily Orius spp.) were not significantly different on Bt versus non-Bt hybrids. Ears with husks flush with the ear tip or with ear tips exposed had significantly higher sap beetle damage for both hybrids, and the Bt hybrids had significantly higher incidence of exposed ear tips in both years. Sap beetle numbers determined by scouting were often proportional to numbers of beetles captured in baited traps, increasing and decreasing at about the same time. However, values determined with traps were typically less variable than when scouted, and time of sampling was typically four times more rapid for each trap than for each 10 plant scout sample when measured in 1999.
Preparation and Properties of Optically Clear Poly[(Arylenedioxy)(Diphenylsilylene)]s and Poly[(Alkylenedioxy)(Diphenylsilylene)] (2003)

Several types of poly[(arylenedioxy)(diphenylsilylene)]s and poly[(alkylenedioxy)(diphenylsilylene)] were synthesized from various diols and dichlorodiphenylsilane by the step polymerization method. The thermal properties, solubility in organic solvents and optical properties of the obtained polymers were investigated by focusing on the chemical structures of their repeating structural units. The weight-average molecular weight ( Mw) of the obtained polymers based on polystyrene ranged from 43000 to 194000. High molecular weight, ductile materials with a high degree of optical clarity were obtained. These polymers display glass transition temperatures ( Tg) between 96 and 130°C. The obtained poly[(arylenedioxy) (diphenylsilylene)]s and poly[(alkylenedioxy)(diphenylsilylene)] were soluble in chloroform and toluene. The refractive index ( nd) was 1.64 for a biphenol-based poly[(arylenedioxy)(diphenylsilylene)] and 1.61 for a bisphenol-A based poly[(arylenedioxy)(diphenylsilylene)]. The poly[(arylenedioxy)(diphenylsilylene)]s and poly[(alkylenedioxy)(diphenylsilylene)] display very low birefringence (Δ n) between 0.0005 and 0.0022. The 70 μm thick film transmission of bicyclohexanol-based poly[(alkylenedioxy)(diphenylsilylene)] was 91% at a 350 nm wavelength.
A wideband circularly-polarized patch antenna for array applications (2013)

A compact (38.9 mm diameter by 12.7 mm tall) patch antenna was designed for applications requiring circular polarization and high gain at the horizon. The circular microstrip patch element was fed with four L-shaped probe feeds and a broadband feed network to produce a right hand circularly polarized (RHCP) antenna with broad impedance and axial ratio bandwidths covering 1.05 GHz to 2 GHz. This design enables antenna diameter reduction compared with patch antennas utilizing air substrates. This patch element is suitable for wideband phased array applications.
Dynamic Characterization of a DNA Repair Enzyme:  NMR Studies of [<i>methyl</i>-<sup>13</sup>C]Methionine-Labeled DNA Polymerase β (2004)

Crystallographic characterization of DNA polymerase beta (pol beta) has suggested that multiple-domain and subdomain motions occur during substrate binding and catalysis. NMR studies of [methyl-(13)C]methionine-labeled pol beta were conducted to characterize the structural and dynamic response to ligand binding. The enzyme contains seven methionine residues, one of which is at the amino terminus and is partially removed by the expression system. Three of the methyl resonances were readily assigned using site-directed mutants. Assignment of the resonances of Met155, Met158, and Met191 was more difficult due to the spatial proximity of these residues, so that assignments were based on NOESY-HSQC data and on the response to paramagnetic Co(2+) addition, as well as shift perturbations observed for the site-directed mutants. The response of the methyl resonances to substrate binding was evaluated by the serial addition of a template oligonucleotide, a downstream 5'-phosphorylated oligonucleotide, and a primer oligonucleotide to create a two-nucleotide-gapped DNA substrate. Addition of the single-stranded template DNA resulted in selective broadening of the methyl resonance of Met18 in the 8 kDa lyase domain, and this resonance then shifted and sharpened upon addition of a 5'-phosphate-terminated downstream complementary oligonucleotide. Conversion of the two-nucleotide-gapped DNA substrate to a single-nucleotide-gapped substrate by incorporation of ddCMP produced a small perturbation of the Met236 resonance, which makes contact with the primer strand in the crystal structure. The addition of a second equivalent of ddCTP to form the pol beta-DNA-ddCTP ternary complex resulted in significant shifts for the resonances corresponding to Met155, Met191, Met236, and Met282. The Met155 methyl resonance is severely broadened, while the Met191 and Met282 resonances exhibit significant but less extreme broadening. Since only Met236 makes contact with the substrate, the effects on Met155, Met236, and Met282 result from indirect conformational and dynamic perturbations. Previous crystallographic characterization of this abortive complex indicated that a polymerase subdomain or segment (alpha-helix N) repositions itself to form one face of the binding pocket for the nascent base pair. Met282 serves as a probe for motion in this segment. Addition of Mg(2+)-dATP to pol beta in the absence of DNA produced qualitatively similar but much smaller effects on Met191 and Met155, but did not strongly perturb Met282, leading to the conclusion that Mg(2+)-dATP alone is insufficient to produce the large conformational changes that are observed in the abortive complex involving the gapped DNA with a blocked primer and ddNTP. Thus, the NMR data indicate that the nucleotide-DNA interaction appears to be essential for conformational activation.
Interactions between protonated retinal schiff base and various counter ions: A study by two‐dimensional NOE NMR spectroscopy (1987)

Abstract Using two‐dimensional NMR spectroscopy, the spatial location of various carboxylate anions relative to the polyene chain of the protonated Schiff base of all‐ trans ‐retinal was determined. The observed intermolecular NOE cross‐peaks between a proton on the counter ion and a proton near the nitrogen atom indicate the existence of ion‐pair formation between the protonated retinal Schiff base and various counter ions in chloroform. The results suggest that the most likely site of the carboxylate group of the counter ion is in the immediate vicinity of the positively charged nitrogen atom of the retinal Schiff base.
Adsorption and Reaction of [Re2(CO)10] on Ultrathin MgO Films Grown on a Mo(110) Surface: Characterization by Infrared Reflection-Absorption Spectroscopy and Temperature-Programmed Desorption (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption and Reaction of [Re2(CO)10] on Ultrathin MgO Films Grown on a Mo(110) Surface: Characterization by Infrared Reflection-Absorption Spectroscopy and Temperature-Programmed DesorptionS. K. Purnell, X. Xu, D. W. Goodman, and B. C. GatesCite this: J. Phys. Chem. 1994, 98, 15, 4076–4082Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/j100066a028https://doi.org/10.1021/j100066a028research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Seed Coating Increase Broccoli Nutrient Content and Availability after Cooking (2014)

Broccoli is a rich source of minerals which play an important role in health. From farm to food there are many processes that affect the mineral nutritional quality. As the quality of the seeds is the basis for the successful production, the protection of seeds by coating is studied to improve the seed quality and maintenance during storage. Also, the studies about the implication in the development of the plants are carried out. For that, the influence of seed capsulation on yield, mineral content, CO2 fixation and gas exchange was determined. The results showed that capsulation treatment improves germination and vegetative growth and production. This may be due to greater absorption of N and Fe and higher C fixation. When inflorescences were cooked, there was a greater loss of mineral nutrients with high pressure and microwave, and lower loss with steaming.
KRAS-dependent sorting of miRNA to exosomes (2015)

Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also contribute to changes in gene expression in recipient cells, and whether mutant KRAS might regulate the composition of secreted microRNAs (miRNAs), we compared small RNAs of cells and matched exosomes from isogenic CRC cell lines differing only in KRAS status. We show that exosomal profiles are distinct from cellular profiles, and mutant exosomes cluster separately from wild-type KRAS exosomes. miR-10b was selectively increased in wild-type exosomes, while miR-100 was increased in mutant exosomes. Neutral sphingomyelinase inhibition caused accumulation of miR-100 only in mutant cells, suggesting KRAS-dependent miRNA export. In Transwell co-culture experiments, mutant donor cells conferred miR-100-mediated target repression in wild-type-recipient cells. These findings suggest that extracellular miRNAs can function in target cells and uncover a potential new mode of action for mutant KRAS in CRC.
Comparison of Performance Characteristics of Axial-Flux Permanent-Magnet Synchronous Machine With Different Magnet Shapes (2015)

To compete with other types of electrical machines as well as other manufacturers, the performance characteristics of axial-flux permanent-magnet (AFPM) machines should be improved. Reduction of the higher harmonic components from the induced back electromotive force is preferred during design process of an electrical machine. To achieve an almost sinusoidal induced phase voltage, a sinusoidal air-gap flux density distribution should be produced. Furthermore, in order to easy startup and also less noisy performance of electrical machines, the cogging torque of the machine should be reduced. In this paper, the surface-mounted AFPM machines equipped with magnets with different outlines are investigated and the machine performances are computed via 3-D finite-element analysis. According to the obtained results, magnets with sinusoidal outline offer better performance characteristics compared with cylindrical and sector-like magnets.
Benefits of Apixaban over Warfarin are Consistent, Irrespective of TTR (2011)

The results of a subanalysis of data from ARISTOTLE, demonstrated that the benefit of apixaban over warfarin was not related to the quality of INR control at the individual ARISTOTLE study centers.
Adverse Childhood Experiences Increase Risk for Ischemic Heart Disease (2004)

The search continues for factors that increase the risk for ischemic heart disease (IHD), a major cause of morbidity and mortality. These researchers used data from the Adverse Childhood Experiences (ACEs) Study to determine whether untoward events early in life are associated with an increased risk for IHD. The …
A Water‐Soluble Mechanochromic Luminescent Pyrene Derivative Exhibiting Recovery of the Initial Photoluminescence Color in a High‐Humidity Environment (2013)

Abstract Switching of the luminescence properties of molecular materials in response to mechanical stimulation is of fundamental interest and also has a range of potential applications. Herein, a water‐soluble mechanochromic luminescent pyrene derivative having two hydrophilic dendrons is reported. This pyrene derivative is the first example of a mechanochromic luminescent organic compound that responds to relative humidity. Mechanical stimulation (grinding) of this pyrene derivative in the solid state results in a change of the photoluminescence from yellow to green. Subsequent exposure to water vapor induces recovery of the initial yellow photoluminescence. The color change is reversible through at least ten cycles. It is also demonstrated that this compound can be applied as a mechano‐sensing material in frictional wear testing for grease, owing to its immiscibility in non‐polar solvents and its non‐crystalline behavior. Transmission electron microscope and atomic force microscope observations of samples prepared from dilute aqueous solutions of the pyrene derivative on suitable substrates, together with dynamic light scattering measurements for the compound in aqueous solution, indicate that this amphiphilic dumbbell‐shaped molecule forms micelles in water.