gebhart/patrepeval huggingface dataset:
Numerical Prediction And Experimental Validation Of Rotor Thermal Instability (2015)

The increasing demand of higher efficiency and increased equipment compactness is pushing the modern rotordynamic design towards higher and higher bearing peripheral speeds.Due to the increased viscous dissipation, fluid film bearings are prone to the development of rotor asymmetrical heating (de Jongh 1994) and hence thermal rotor bowing, rotor thermal imbalance and consequent synchronous vibration increase.Differential heating and synchronous rotor vibrations are directly linked leading to a complex feedback loop which can cause thermal rotor instability often referred as Morton effect (de Jongh 1994).In the present work, the stability of a rotor bearing system is numerically simulated following two different approaches: a classical linear stability approach suggested by Murphy et al. (Murphy 2009) and an iterative FEM thermo-structural-dynamic analysis.Results are compared with measurements obtained during an experimental campaign carried out at the GE oil & Gas facility in Florence on a real scale between-bearing dummy rotor.During the experiments, the rotor differential temperature at the journal bearing section has been continuously monitored via telemetry as well as rotor vibration at bearing, mid span and overhung location.For the linear stability approach, the rotor differential temperature is estimated by making use of a steady thin-film tilting pad journal bearing (TPJB) code developed at the Department of Industrial Engineering of the University of Florence while the iterative method takes advantage of an experimentally fit correlation between rotor vibration and differential rotor temperature used to couple the dynamic and thermo-structural rotor simulations.
MODELING GENE EXPRESSION WITH DIFFERENTIAL EQUATIONS (1998)

We propose a differential equation model for gene expression and provide two methods to construct the model from a set of temporal data. We model both transcription and translation by kinetic equations with feedback loops from translation products to transcription. Degradation of proteins and mRNAs is also incorporated. We study two methods to construct the model from experimental data: Minimum Weight Solutions to Linear Equations (MWSLE), which determines the regulation by solving under-determined linear equations, and Fourier Transform for Stable Systems (FTSS), which refines the model with cell cycle constraints. The results suggest that a minor set of temporal data may be sufficient to construct the model at the genome level. We also give a comprehensive discussion of other extended models: the RNA Model, the Protein Model, and the Time Delay Model.
14.ALPHA.-Hydroxyandrost-4-ene-3,6,17-trione as a mechanical-based irreversible inhibitor of estrogen biosynthesis. (1990)

Various derivatives of androst-4-ene-3,17-dione derived from microbial transformation were evaluated as inhibitors of human placental aromatase. 14 alpha-Hydroxyandrost-4-ene-3,6,17-trione was the most potent inhibitor showing a time-dependent, pseudo-first-order inactivation of aromatase in the presence of reduced nicotinamide adenine dinucleotide phosphate with apparent Ki of 1.3 microM and Kinact of 0.23 min-1. This compound also inhibited aromatase in rat ovary and suppressed serum estradiol levels in in vivo experiments.
Effect of sympathetic nerve stimulation and adrenoceptor blockade on pial arterial and venous calibre and on intracranial pressure in the cat (1983)

Pial arterial and venous calibre were continuously recorded through a closed cranial window preparation during cervical sympathetic nerve stimulation in 10 cats before and after alpha- and beta-adrenoceptor blockade. In addition, the intracranial pressure (ICP) was simultaneously recorded in 4 of the cats. Under resting conditions 33 arteries (mean diameter 130 micron) constricted by 11.7 +/- 0.8% and 80 venous portions (mean diameter 152 micron) constricted by 13.7 +/- 0.7% during sympathetic nerve stimulation. ICP decreased simultaneously by 16.5 +/- 6.2%. Administration of the alpha-adrenoceptor antagonist phenoxybenzamine i.v. (1.5 mg X kg-1) abolished the reduction of ICP and markedly reduced, but did not completely abolish, the constrictor response of arteries and veins. The beta-adrenoceptor antagonist propranolol (1.5 mg X kg-1) did not significantly alter the reduction of ICP or the response of pial veins and small arteries, whereas the response of arteries with a diameter greater than 150 micron was attenuated. It is concluded that the constriction of pial veins and arteries during sympathetic stimulation is mediated predominantly via alpha-adrenoceptors. The sympathetic nerves of cerebral blood vessels may have stronger influence on the cerebral capacitance than on resistance vessels under normotensive and normocapnic conditions.
Assay of hemoglobin A1c using lectin from Aleuria aurantia (2016)

Hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) has an N-terminal fructosyl valine on the β-chain, and this modification is caused by the non-enzymatic glycosylation of hemoglobin (Hb). The relative concentration ratio of HbA<sub>1c</sub> to total Hb is an important biomarker for the diagnosis of diabetes. HbA<sub>1c</sub>-binding lectins were screened from 29 sources of lectin, and the lectin from Aleuria aurantia (AAL) was revealed to have higher affinity to HbA<sub>1c</sub> than to Hb. The concentration of HbA<sub>1c</sub> was determined by lectin-based enzyme-linked immunosorbent assay (ELISA) using the AAL lectin. Higher reproducibility of the assay was observed at 4 °C than at 25 and 37 °C. This observation is consistent with the known temperature-dependent behavior of lectins. Preincubation of HbA<sub>1c</sub> with an anti-HbA<sub>1c</sub> antibody inhibited the binding, suggesting that AAL binds to the N-terminal fructosyl valine epitope of HbA<sub>1c</sub>. Higher inhibitory effect was observed for 10 mM D-fructose than for the same concentrations of L-fucose, D-fucose, or D-glucose.
Repercussões respiratórias e hemodinâmicas do pneumoperitônio na lesão do diafragma: estudo experimental (2007)

We concluded that videolaparoscopy with pneumoperitoneum pressure under 15 mmHg is a safe procedure in patients with diaphragmatic injuries because this pressure level does not cause hemodynamic changes, such as decrease of the cardiac output.
Expression Pattern and Functional Relevance of Epidermal Growth Factor Receptor and Cyclooxygenase-2: Novel Chemotherapeutic Targets in Pancreatic Endocrine Tumors? (2008)

Our results suggest that EGFR and COX-2 may represent useful additional chemotherapeutic targets in pancreatic endocrine tumors.
Book reviews (1993)

R. S. Ersser, R. M. Miller, J. Slater, P. Zuman, P. Vadgama, K. Holly, R. J. Abraham and P. Klaeboe, Analyst, 1993, 118, 42N DOI: 10.1039/AN993180042N
<title>Improved data management for seismic interpretation using compression</title> (1998)

As new methods of interpreting 3D seismic data, particularly prestack and derived attribute data, increase in popularity, the management of ever-larger data volumes becomes critical. Compared with acquisition and processing, however, the interpretation use of seismic data requires faster and non- sequential, random access to large data volumes. In addition, quantitative interpretations lead to an increasing need for full 32-bit resolution of amplitudes, rather than the 8 or 16 bit representations that have been used in most interpretation systems up to the present. Seismic data compression can be a significant tool in managing these on- line datasets, but the implementation previously used (e.g. Donoho, et al. 1995) are not well suited to providing rapid random access in arbitrary directions (CDP, crossline, timeslice). If compression ratios of twenty or greater can be routinely provided, with full random access to all parts of the dataset, then both larger cubes and more cubes can be handled within the finite memory and disk systems available on interpretation systems. Such on-line data accessibility will lead to higher productivity by interpreters and greater value for existing seismic surveys. We address here several problems that arise when using the lossy wavelet-transform data compression algorithms currently available. We demonstrate that wavelet compression introduces less noise than currently accepted truncation compression. We also show how compressing small blocks of data needed for random access leads to artifacts in the data, and we provide a procedure for eliminating these artifacts.
Optical investigations of individual InAs quantum dots:  Level splittings of exciton complexes (1999)

We have investigated individual InAs quantum dots embedded in GaAs using photoluminescence spectroscopy as a function of temperature and excitation power density. We also present $\mathbf{k}\ensuremath{\cdot}\mathbf{p}$ calculations including both direct and exchange interactions for systems with up to three excitons in the dot. From these calculations we are able to assign some of the many peaks observed to various few-particle states. A rate-equation model has also been developed which allows simulations of the peak intensities with excitation power density to be made and compared with experiment.
High speed 3-D imaging using low coherence photorefractive holographic microscopy (2002)

Wide-field low coherence photorefractive holography has the potential to acquire depth-resolved images at up to 1000 frames/second, including through scattering media. We have applied it to microscopy using a diverse range of light sources.
Enhancement of antitumor activity of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine and Baker's antifol (triazinate) with carboxypeptidase G1. (1979)

Carboxypeptidase G1 (CPDG1), an enzyme that degrades folates but not the nonclassical folate antagonists triazinate (TZT, Baker's antifol) and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP), enhanced the antineoplastic activity of these antifolates. In 6-day cell culture experiments with Walker 256 carcinosarcoma, CPDG1 at levels up to 0.54 unit/ml showed very little inhibitory effect on growth. In the presence of 10(-7) M DDMP, the grown of Walker 256 cells was similar to that of controls, but in combination with CPDG1 (0.1 unit/ml) 80% growth inhibition was observed. TZT at a concentration of 10(-8) M did not affect the growth of Walker 256 cells. The combination of 10(-8) M TZT with CPDG1 (0.1 unit/ml), however, strongly inhibited cell growth. In experiments with rats bearing Walker 256 carcinosarcoma, the administration of CPDG1 (800 units/kg/day) from Day 1 to Day 6 resulted in no significant increase in life span. Administration of TZT in doses up to 0.05 mg/kg on Day 1 or that of DDMP up to 15 mg/kg on Days 1, 3, and 5 had no antitumor effects as measured by survival of the animals. However, CPDG1 (800 units/kg/day) from Day 1 to Day 6 in combination with TZT (0.05 mg/kg on Day 1) or DDMP (15 mg/kg on Days 1, 3, and 5) resulted in increases of 50 and 30%, respectively, in the survival of the tumor-bearing animals. These results demonstrate that CPDG1 enhances the antitumor effects of TZT or DDMP.
Time-varying spectra for underspread and overspread nonstationary processes (2002)

We introduce an extended concept of underspread and overspread nonstationary random processes and show its importance for time-varying spectral analysis. We consider two classes of time-varying power spectra that comprise most existing spectra, including Wigner-Ville and evolutionary spectra. For underspread processes, all spectra are shown to yield similar results. For overspread processes, the spectra may yield very different results and contain oscillatory "cross-terms" indicating time-frequency correlations. These cross-terms can be attenuated via smoothing techniques.
Management of Patients with the Hereditary Long QT Syndrome (1998)

The hereditary long QT syndrome is an inherited ion channel disorder with QT prolongation, morphologic changes in the T waves, and a relatively high frequency of syncope, T wave alternans, torsades de pointes-type ventricular tachycardia, and sudden death. Monotherapy with beta blockers is the treatment of first choice. In patients with recurrent syncope despite therapy with beta blockers, pacemakers and/or ganglionectomy may be useful in selected cases, with an implantable cardioverter defibrillator used as a fail-safe approach in high-risk patients.
Studies on the Sidedness of the Human Red Blood Cell Membrane: Preparation of Stable Azo-Erthrocytes (1981)

Para-diazobenzenesulfonic acid (DBSA), a non-penetrating compound, which reacts with proteins of the external surface of intact cells, was used for the preparation of AZO-erythrocytes. When coupling of p-diazobenzenesulfonic acid to human red blood cells was carried out in phosphate-buffered saline (PBS), the cells lysed within one hour, before the completion of the reaction. Elimination of sodium chloride from the reaction mixture allowed the completion of coupling by prolonging the survival of red blood cells in he diazonium salt from one hour to three hours. The survival of human erythrocytes could be further prolonged to seven hours by carrying out coupling in the presence of cyclic 3',5'-guanosine monophosphate (cGMP). Azo-erythrocytes prepared in the absence of cyclic GMP and washed free of the diazonium salt lysed in phosphate-buffered saline, but remained stable for hours in isosmotic phosphate buffers devoid of sodium chloride ions. Under identical conditions, azo-erythrocytes prepared in the presence of cyclic GMP remained stable for two days and were suited for studies on the functional and structural aspects of red blood cell membrane.
Heavy chain variable region. Multiple gene segments encode anti-4-(hydroxy-3-nitro-phenyl)acetyl idiotypic antibodies. (1985)

The hapten (4-hydroxy-3-nitrophenyl)acetyl (NP), when conjugated to carrier proteins, elicits a characteristic idiotypic response (NPb) in C57BL/6 mice. The response can be divided serologically into two distinct NPb-positive groups of antibodies. The first group consists of four crossreacting subgroups (I-IV), the second of two subgroups (V, VI). Some antibodies of subgroups I and II have been shown to express the unmutated heavy chain variable region (VH) germline gene 186.2. Antibodies of subgroups V and VI crossreact extensively with the NPa-positive antibodies of BALB/c mice. We sequenced heavy chain complementary DNA from eight hybridomas producing anti-NP antibodies. Six of these belong to subgroups V and VI, and two were NPa-positive hybridomas of BALB/c origin. All sequences were homologous to each other, and differed by approximately 80 basepairs from the 186.2 C57BL/6 germline VH gene. From our sequence and Southern blot analyses we suggest: (a) the NPb idiotypic response is the product of several VH germline genes, (b) some of these genes are very homologous to the gene coding for the BALB/c NPa idiotype, and might represent the C57BL/6 allelic forms of this gene, (c) the diversity regions of NPb and NPa-positive antibodies are diverse in length and amino acid composition, except for the first residue, which is always tyrosine, (d) all four heavy chain joining region gene segments are expressed without mutation. We discuss our data in terms of diversity in the germline VH gene repertoire, as well as diversity created by gene segment-joining events and somatic mutation.
BCG Specificity of an inhibitory seric factor from tuberculosis anergic patients that acts on non-adherent ppd reactive cells (1997)

The effect of tuberculosis anergic immune sera adsorbed with BCG was studied on cocultures of adherent and non-adherent cells from PPD+ tuberculosis patient (TBP PPD+). This effect on the cocultures was quantified by lymphocyte transformation (LT) test using PPD as antigen. Only those cocultures with non-adherent cells from TBP PPD+ patients treated with anergic sera, inhibited the LT response induced by PPD, whereas sera adsorption with BCG eliminated the inhibitory effect.
Super-Resolution Imaging With Ultrafast Ultrasound Imaging of Optically Triggered Perfluorohexane Nanodroplets (2018)

Super-resolution imaging with moving microbubbles has shown potential in identifying fine details of deep-lying vascular compartments. To image the extravascular targets, this paper has employed nanometer-sized, optically triggered perfluorohexane nanodroplets (PFHnDs). In response to pulsed laser irradiation, the PFHnDs repeatedly vaporize and stochastically recondense, resulting in random changes of ultrasound signals. Our previous study has shown that the stochastic recondensation of the PFHnDs can be used to isolate individual PFHnDs for super-resolution imaging. This paper introduces an improved method for super-resolution imaging with ultrafast ultrasound imaging of PFHnDs. The previous method was based on subtraction of two consecutive ultrasound images to detect signals from recondensed, isolated droplets, whereas our current method compounds respective multiple pre- and post-recondensation ultrafast ultrasound images prior to subtraction to improve the spatial resolution further. To evaluate the axial and lateral resolutions of our method, we repeatedly imaged a phantom containing PFHnDs using a programmable ultrasound system synchronized with a pulsed laser system. As a result, our method improved the lateral and axial resolutions by 54% and 68%, respectively, over the previous super-resolution imaging approach, indicating that it can be used for localizing extravascular molecular targets with superior accuracy.
Worldwide Regulations on Aflatoxins* (2005)

A need has always been felt for some control on the quality of foodstuffs. Such control is intended to protect the health of the consumer and to prevent misrepresentation with respect to the composition of food. In the days of early food legislation, the protection of food was mostly local, and municipal ordinances were promulgated for that purpose. Later, when auxiliary sciences such as bacteriology, chemistry, and microbiology developed, statutory regulations were initiated in many countries, leading, at the beginning of the twentieth century, to the adoption of ofﬁcial food legislation and regulations.
The α-iso-cubebenol compound isolated from Schisandra chinensis induces p53-independent pathway-mediated apoptosis in hepatocellular carcinoma cells (2012)

Schisandra chinensis (S. chinensis) plants are extensively used because of their anticancer, anti-inflammatory, antioxidant and antihepatic activities. However, their active compounds remain to be clearly determined. In this study, we investigated the antitumor functions of α-iso-cubebenol (αIC) isolated from S. chinensis using HepG2 hepatocellular carcinoma cells. HepG2 cells were exposed to αIC for 24 h, and apoptosis was assessed using standard viability and cell proliferation assays, flow cytometry and western blotting. HepG2 cell populations treated only with 340 µM of αIC showed markedly increased cell death, but lower concentrations induced minimal alterations of population viability and cell morphology. However, the results of flow cytometry showed that the majority of viable cells were undergoing apoptosis at all tested αIC concentrations. Western blot analysis results revealed a significant and αIC concentration-dependent reduction in the levels of the pro-caspase-3 apoptotic protein and the Bcl-2 anti-apoptotic protein. In particular, the Bax pro-apoptosis protein and p53 (which regulates Bax expression) showed different expression patterns after the application of αIC treatment to HepG2 cells. Bax expression was slightly increased in cells treated with the high concentration of αIC, while p53 expression was markedly reduced in a dose-dependent fashion, similar to that of Bcl-2. The results of this study suggest that αIC is an anticancer drug candidate by virtue of its apoptotic induction abilities in hepatocellular carcinoma cells, which occur via a p53-independent pathway.
Synthesis of Structurally Simplified Aureolic Acid Aglycone-C-D-E Trisaccharide Analogues (2002)

Syntheses of aureolic acid analogues (5) and (6) with (2 S )- and (2 R )-acyloin stereochemistry, respectively, are described. The synthesis of (5) utilizes a `C + DE' glycosidation sequence, whereas analogue (6), with unnatural (2 R )-acyloin stereochemistry, was synthesized by a sequence in which the entire C-D-E trisaccharide was introduced in a single step. While these syntheses provided sufficient quantities of the two aureolic acid analogues for use in studies of Mg2+ complex formation and deoxyribonucleic acid (DNA) binding, this work also highlights certain limitations in the use of 2-thiophenyl glycosyl donors for synthesis of 2-deoxy-ß-glycosides. Specifically, difficulties were encountered in the identification of a protecting group for the aglycone C8 phenol that is fully compatible with the conditions required for reductive removal of the thiophenyl substituents after completion of the glycosidation sequence. Sensitivity of the C2 acyloin stereocentre to the conditions required for deprotection of a phenolic acetate ester are also highlighted in the syntheses of (5), and especially of (6).
SP-100 space reactor power system for lunar, Mars, and robotic exploration (1992)

The SP-100 power system is described which was developed for three missions, namely, Pluto Orbiter with nuclear electric propulsion; human-rated surface reactor power system for lunar and Mars exploration; and earth surveillance with an integrated nuclear electric propulsion system. The reactor power systems technology is being developed to meet these requirements so that the technical database, design tools, and specifications will be applicable to these missions. The SP-100 power system design includes the following subsystems: reactor, reactor instrumentation and control, shield, heat transport, converter, heat rejection, power conditioning control and distribution, and mechanical/structural. Particular attention is given to a demonstration mission aimed at validating technology readiness for robotic, lunar, and Mars operational missions.
Elastases from Human and Canine Granulocytes, II. Interaction with Protease Inhibitors of Animal, Plant, and Microbial Origin (1977)

Inhibitors of animal, plant, and microbial origin were tested against human and canine granulocytic elastases. The trypsin-chymotrypsin inhibitors from dog submandibular glands, from soybeans (Bowman-Birk) and from chickpeas show strong interaction with these proteases (Ki = 10(-8) - 10(-9)M). The trypsin-kallikrein inactivator of bovine organs (Trasylol) is not active against granulocytic elastases or against human granulocytic cathepsin G. Elastatinal, a specific inhibitor of elastases, isolated from actinomycetes (Streptomyces griseoruber), forms stable complexes with elastase from human (Ki = 6.2 X 10(-6)M) and canine granulocytes (Ki = 1.1 X 10(-6)M). A possible therapeutic application of these inhibitors for the inactivation of granulocytic proteases, which are able to degrade connective tissue in different pathological states, is discussed.