gebhart/patrepeval huggingface dataset:
Accidental Exposure to UV Radiation Produced by Germicidal Lamp: Case Report and Risk Assessment (2012)

Ultraviolet radiation is known to cause both benefits and harmful effects on humans. The adverse effects mainly involve two target organs, skin and eye, and can be further divided into short- and long-term effects. The present case report describes an accidental exposure of two health-care workers to ultraviolet radiation produced by a germicidal lamp in a hospital pharmacy. The germicidal lamp presented a spectrum with an intense UV-C component as well as a modest UV-B contribution. Overexposure to UV-C radiation was over 100 times as large as the ICNIRP exposure limits. A few hours after the exposure, the two subjects reported symptoms of acute UV injury and both of them continued having significant clinical signs for over 2 years. In this study, we describe acute and potentially irreversible effects caused by high UV exposure. In addition, we present the results of risk assessment by occupational exposure to germicidal lamps.
Studies on the content of antibodies for equine influenza viruses in human sera. (1966)

Previous workers had demonstrated that some of the viruses that caused the influenza epizootics of 1956 and 1963 among horses are antigenically related to certain human influenza viruses. The present authors therefore studied the distribution of antibodies for the equine influenza viruses in human sera. They found that three strains of A/Equi 2 virus (1963 Miami, 1963 Richelieu and 1963 Milford) are antigenically related and that there is a cross-relationship between the mouse line of the equine influenza A/Equi 1 (1956 Praha) antiserum and the 1963 A/Equi 2 strains. Haemagglutination-inhibition (HI) antibodies for A/Equi 2/Richelieu/63 were found in only 2 of 434 sera taken in 1963 from people aged less than 60 years but in 50 of 435 sera from people aged 60 years or more. These results suggest that infection with a virus resembling the A/Equi 2 1963 strain occurred some 7-10 years after the 1889-90 influenza pandemic; this virus was probably a mutant of the influenza A2 virus, which may have been the cause of the 1889-90 pandemic.
Epigenetic Regulation in Substance Use Disorders (2010)

Substance use disorder is a chronic condition of compulsive drug seeking and use that is mediated by stable changes in central reward pathways. Repeated use of abused drugs causes persistent alterations in gene expression responsible for the long-term behavioral and structural changes. Recently, it has been suggested that epigenetic mechanisms are responsible in part for these drug-induced changes in gene expression. One of the alluring aspects of epigenetic regulation of gene expression is that epigenetic mechanisms may provide transient and potentially stable conditions that in turn may ultimately participate in the molecular mechanisms required for neuronal changes subserving long-lasting changes in behavior. This review describes epigenetic mechanisms of gene regulation and then discusses the emerging role of epigenetics in drug-induced plasticity and behavior. Understanding these mechanisms that establish and maintain drug-dependent plasticity changes may lead to deeper understanding of substance use disorders as well as novel approaches to treatment.
Measurement of Remaining Oil Saturation in Northern Michigan Using Nuclear Magnetism Log Data and Pressure Core (1985)

ABSTRACT Remaining oil saturation measurements were made in a pinnacle reef field of Northern Michigan. Pressure core was taken in the Al Carbonate and Niagaran formations. A Nuclear Magnetism Inject-Log procedure was used as an independent measure of remaining oil saturation. Using procedures outlined in this paper, the core-measured and log-derived remaining oil saturations agree, well within their error limits.
Assessment of 2,4,6-trinitrotoluene toxicity in field soils by pollution-induced community tolerance, denaturing gradient gel electrophoresis, and seed germination assay (2000)

Abstract Determining the toxicity of contaminants to soil organisms under field conditions is hampered by site-specific and temporal factors that modulate contaminant availability. Assessing the pollution-induced community tolerance (PICT) of indigenous microbial communities integrates these complex environmental factors. The purpose of this study was to determine if the PICT response was proportional to 2,4,6-trinitrotoluene (TNT) concentrations in soil, if changes detected by PICT were also evident in soil microbial community composition, and if the PICT response correlated with phytotoxicity assays. Microorganisms extracted from TNT-contaminated field soils were mixed with a solution containing six different concentrations of TNT and inoculated into Biolog ECO plates. The utilization rate of substrates was determined over a 7-d period. Denaturing gradient gel electrophoretic analysis of a portion of the gene encoding 16S rDNA described the structure of the soil microbial community. Phytoindicators (Poa compressa and P. palustris L.) of TNT pollution were identified and used to assess TNT phytotoxicity in soil samples. The TNT (in Biolog wells) greatly inhibited microbial communities from locations with low in situ TNT exposure. The inhibition of microbial use of L-asparagine, L-phenylalanine, and D-glucosaminic acid by TNT (in Biolog wells) increased as TNT concentration in soil decreased. Locations differing in ECO-PICT response also differed in their microbial community composition and TNT phytotoxicity. Decreased phytotoxicity of field soils corresponded to decreases in PICT. The results from this study indicated that ECO-PICT is an effective assay to rapidly detect TNT exposure and toxicity in soil microbial communities.
HotPoint: hot spot prediction server for protein interfaces (2010)

The energy distribution along the protein-protein interface is not homogenous; certain residues contribute more to the binding free energy, called 'hot spots'. Here, we present a web server, HotPoint, which predicts hot spots in protein interfaces using an empirical model. The empirical model incorporates a few simple rules consisting of occlusion from solvent and total knowledge-based pair potentials of residues. The prediction model is computationally efficient and achieves high accuracy of 70%. The input to the HotPoint server is a protein complex and two chain identifiers that form an interface. The server provides the hot spot prediction results, a table of residue properties and an interactive 3D visualization of the complex with hot spots highlighted. Results are also downloadable as text files. This web server can be used for analysis of any protein-protein interface which can be utilized by researchers working on binding sites characterization and rational design of small molecules for protein interactions. HotPoint is accessible at http://prism.ccbb.ku.edu.tr/hotpoint.
Learning what works : a 20 year retrospective view on international water and sanitation cooperation (1998)

This year marks the twentieth year of the UNDP-World Bank Water and Sanitation Program. The author traces the developments in the water and sanitation sector since the program's inception in 1978, and analyzes how the program has affected by these developments. The case study represents an attempt to describe in parallel the evolution of the program and the evolution of international thinking concerning water and sanitation during the 20 years of the program's existence.
Research on developing modes of simulation system in Simulation Grid (2008)

The combination of grid technology and M&S (Modeling and Simulation) is an important direction for distributed simulation nowadays, and SimuGrid (Simulation Grid) we are developing is a research project aiming at this direction. In this paper, we describe the development of simulation application in SimuGrid by proposing three modes of simulation system development including batch-job mode, federate implemented mode and simulation description mode. The utilization of simulation resources shared in SimuGrid environment increases gradually from batch- job mode to mode with implemented federate and to simulation description mode. Especially for the rich use of all kinds of simulation resources and the high automatic level in simulation description mode, we make emphatic discussion on this mode in developing process, implementation elements, data visualization and collaborative work. The implementation of simulation application based on SimuGrid decreases the threshold for user, makes easy for simulation development and enhances reuse of simulation models.
Supporting<i>Science</i>Learning through<i>Science</i>Literacy Objectives for<i>English</i>Language Learners (2005)

The author provides information on how science teachers can write science literacy objectives that help English language learners (ELLs) develop the scientific literacy needed for academic success in the science classroom. The article offers suggestions on how teachers can determine the vocabulary, language functions, and sentence structures that their students need to engage in critical thinking in science. An approach for collaboration with students' English as a second language (ESL) teacher is discussed.
A Rapid Microdetermination of Water in Chlorinated Hydrocarbons by Gas Chromatography (1970)

Abstract A fast and sensitive gas chromatographic procedure for the control of moisture in chlorinated hydrocarbons at the ppm level is described. The basic features are a combination of two types of polyaromatic beads as column packing, locally produced hydrogen as carrier gas, and a backflushing system. The latter reverses the carrier gas flow after elution of the water peak at increased pressure. The instrument is thus readied for subsequent analyses at intervals of 2–3 min. The system can be used for moisture analyses in most gases and liquids. It is particularly applicable where a large number of samples have to be checked continually and instant results are required.
Prostatic and extraprostatic alpha-adrenoceptors--contributions to the lower urinary tract symptoms in benign prostatic hyperplasia. (1996)

The beneficial effects of alpha-adrenoceptor antagonists on lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH), and the lack of correlation between LUTS on the one hand and prostatic enlargement and/or outflow obstruction on the other, have focused interest on the role of extraprostatic alpha-adrenoceptors in the pathogenesis of LUTS. In addition to their well documented site of action on prostatic and lower urinary tract smooth muscle, alpha-adrenoceptors antagonists may act at the level of the spinal cord, ganglia, and nerve terminals to influence the sympathetic and parasympathetic outflows to the bladder, bladder neck. prostate, and external urethral sphincter. A more complete understanding of the role of alpha-adrenoceptors in the overall autonomic control of the lower urinary tract will be required to design agents that can improve alpha-adrenoceptor antagonist treatment of BPH.
Irreversible enzyme inhibitors. CXXV. Active site-directed irreversible inhibitors of xanthine oxidase derived from arylpurines and pyrazolo[3,4-d]pyrimidines bearing a terminal sulfonyl fluoride (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIrreversible enzyme inhibitors. CXXV. Active site-directed irreversible inhibitors of xanthine oxidase derived from arylpurines and pyrazolo[3,4-d]pyrimidines bearing a terminal sulfonyl fluorideB. R. Baker and Janos A. KozmaCite this: J. Med. Chem. 1968, 11, 4, 656–661Publication Date (Print):July 1, 1968Publication History Published online1 May 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/jm00310a005https://doi.org/10.1021/jm00310a005research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cardiovascular signal reconstruction based on shape modelling and non-stationary temporal modelling (2012)

Physiological signals, specially those related to cardiovascular function, are usually corrupted due to the number of degradation sources appearing in the acquisition process (noise, movements, etc.). If the power of these artifacts is close to the power of the signal, they cannot be removed and the affected epoch must be set aside. In this paper, we propose a novel methodology for reconstructing corrupted pieces based on signal modelling. The method consists of two stages: 1) estimation of the model parameters from the largest uncorrupted signal and 2) simulation of the model to achieve a new piece able to replace the corrupted one. Results on real data show that reconstructed pieces are valid in terms of statistical similarity, yielding anomaly-free realizations of the stochastic process modelling the acquired signal.
EFFECT OF SHORT-TERM SENSITIVITY LOSS IN LiF:Mg,Cu,P THERMOLUMINESCENT DOSEMETER AND ITS IMPLICATIONS ON PERSONNEL DOSIMETRY OPERATIONS (2015)

A short-term sensitivity loss in LiF:Mg,Cu,P thermoluminescent dosemeters (TLDs) was observed and is described. Its observation occurred during a pre-irradiation anneal with a slightly elevated maximum temperature (5-15°C), which causes notable under-response (5-10 %) of the subsequent read at the recommended time-temperature profile (TTP), which has a peak temperature of 260°C. A subsequent irradiation and reading using the recommended TTP showed partial or complete recovery of the TLD's sensitivity. To the best of our knowledge, there were no publications on possible implications of a one-time 5-15°C overheat of LiF:Mg,Cu,P TLDs during anneal. This is not unusual when several readers with some variations in their heating cycles are used to calibrate and process the same population of dosemeters. A special test to identify if a small uncontrolled overheating of a dosemeter element has occurred was developed and tested. Two practical implications of the effect of a short-term sensitivity loss in LiF:Mg,Cu,P, e.g. inconsistency in results of metrological traceability verification and reporting of false neutron doses, are described in detail. Simple indicators of a small uncontrolled overheating are provided.
The distortion of a jet by tabs (1975)

In an attempt to explain the discrepancies that have been observed in the spread of nominally axisymmetric jets, an experimental investigation has been carried out in which the effects of a number of factors which it was thought might be important to jet development have been studied. These factors included the nozzle boundary-layer thickness, turbulence level and convergence. However, over the limited range of the tests, it was found that none of these factors had a very strong influence on the jet development. By contrast, the insertion of small rectangular tabs into the jet flow on the nozzle perimeter was found to have a very profound effect on the jet development. In particular, it was found that just two tabs produced gross distortions in the jet development resulting in the jet almost splitting in two with high velocity regions on either side of the diameter joining the tabs. Some explanations for this effect based on further tests with wedges are put forward. In addition to the measurements of the mean flow field, a few spectrum and correlation measurements are reported for jets both from a clean nozzle and also from a nozzle with two tabs. In the former tests, evidence additional to the results of other experimenters was found for the existence of flow structures which have some coherence around the entire circumference of the jet. It has been suggested that these ‘vortex rings’ or ‘puffs’ may be of some importance in producing jet noise and it seems that the effect of inserting tabs is to prevent the occurrence of these structures.
Economic Activity Analyses: The Need for Consensus (2014)

Extension professionals have shown eagerness and creativity when it comes to providing programming justification. However, the potential for misapplication of two common economic activity analyses requires Extension to standardized economic impact and economic contribution techniques. Readers are introduced to the cornerstones of economic activity analyses and are offered interpretations on the methodology needed to conduct an accurate impact or contribution analysis. Additionally, the authors suggest several other essential considerations that need to be addressed when undertaking any economic activity analysis. Other Extension professionals should look to this article and either show support or critique the proposed interpretations.
Buckling Behavior of Well Tubing: The Packer Effect (1982)

Abstract The equilibrium equations for a helically buckled tubing are developed and solved directly. The results show that the packer has a strong influence on the pitch of the helix, and that the pitch developed by the helix is different from the pitch calculated by conventional methods. In addition, the solution provides (1) shear loads and bending moments at the packer and (2) constraining force exerted on the tubing by the exterior casing. This last result can be used to estimate friction effects on tubing buckling.
Detection and Re-routing of elephant flows in a Software Defined Networking to avoid traffic congestion (2018)

Software Defined Networking (SDN) is widely used in datacenters because it makes the network topology exible. It is very crucial to monitor and manage both incoming and outgoing traffic in order to utilize the resources that are available and avoid congestion. In a network, a large/elephant flow absorb more network bandwidth as well as takes time to get processed which impacts QoS. In this paper, a variety of approaches are discussed for detection of elephant flows and routing algorithms. The proposed routing algorithm scans the network to find all the paths available between source and destination and calculates the link bandwidth of different paths available. This research paper used mininet as network emulator, sFlow for traffic analysis and POX controller along with the OpenFlow protocol to identify the network paths. The algorithm has been tested on a fat tree topology and evaluated against different scenarios. In all the test scenarios, it was possible to detect elephant ows and the algorithm finds first and second best path out of available paths. Ultimately, the second best routing path is displayed which could be opted for the large flow.
Marching into the future : Cape Town focus (2013)

The Western Cape printing and converting industry is bullish in the face of what seems to have been a fairly challenging period. Consolidation in an industry suffering from over-capacity issues bodes well for the ongoing sustainability of the industry here, and across the country.
An Efficient RLS Algorithm For Output-Error Adaptive IIR Filtering And Its Application To Acoustic Echo Cancellation (2007)

In this letter, an efficient recursive least squares (RLS) algorithm using infinite impulse response (IIR) filter for acoustic echo cancellation (AEC) is proposed. The RLS adaptive filter is naturally extended from the finite impulse response (FIR) structure to the IIR structure. One of the main advantages of an IIR RLS filter is that a long-delay echo can be synthesized by a relatively small number of filter coefficients leading to lesser computational complexity. In addition it is more suitable for modeling physical systems, due to its pole-zero structure, over their FIR counterparts. To investigate the tracking performance and the stability of the proposed IIR RLS filter in a practical implementation, real data for far end speech signal and its echo were used in car environment. The proposed algorithm is shown to have global convergence. To demonstrate the effectiveness of the proposed IIR RLS filter, it is compared to the usual FIR RLS filter. The good performance of the proposed IIR RLS algorithm for AEC have been verified via computer simulations
<i>GSK3B</i> polymorphisms alter transcription and splicing in Parkinson's disease (2005)

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a combination of motor symptoms. We identified two functional single nucleotide polymorphisms in the glycogen synthase kinase-3beta gene (GSK3B). A promoter single nucleotide polymorphism (rs334558) is associated with transcriptional strength in vitro in which the T allele has greater activity. An intronic single nucleotide polymorphism (rs6438552) regulates selection of splice acceptor sites in vitro. The T allele is associated with altered splicing in lymphocytes and increased levels of GSK3B transcripts that lack exons 9 and 11 (GSKDeltaexon9+11). Increased levels of GSKDeltaexon9+11 correlated with enhanced phosphorylation of its substrate, Tau. In a comparison of PD and control brains, there was increased in frequency of T allele (rs6438552) and corresponding increase in GSKDeltaexon9+11 and Tau phosphorylation in PD brains. Conditional logistic regression indicated gene-gene interaction between T/T genotype of rs334558 and H1/H1 haplotype of microtubule-associated protein Tau (MAPT) gene (p = 0.009). There was association between a haplotype (T alleles of both GSK3B polymorphisms) and disease risk after stratification by Tau haplotypes ((H1/H2+H2/H2 individuals: odds ratio, 1.64; p = 0.007; (H1/H1 individuals: odds ratio, 0.68; p < 0.001). Ours results suggest GSK3B polymorphisms alter transcription and splicing and interact with Tau haplotypes to modify disease risk in PD.
Autothermal Thermophilic Aerobic Digestion: A Two-Year Appraisal of Canadian Facilities (1991)

Full scale, autothermal thermophilic aerobic digestion (ATAD) facilities were constructed or upgraded in 1988 to demonstrate high temperature aerobic digestion of municipal sludges at three small publicly owned wastewater treatment plants in British Columbia, Canada. Other Canadian installations were later completed in Banff, Alberta, by others in early 1990, and in the Resort Municipality of Whistler, British Columbia under the author's supervision in late 1990. The results of the two year investigation of the three demonstration facilities were used to develop the criteria for the Whistler ATAD facility. The paper presents findings of the 1989 demonstration study and reviews selected design parameters for the Whistler operation.
Protective effect of PEG-SOD against early coronary reperfusion injury assessed in reperfused and non-reperfused ischaemic areas of the same heart (2001)

PEG-SOD prevents infarct extension during early coronary reperfusion.