gebhart/patrepeval huggingface dataset:
Reissert compound chemistry. Part III. Some rearrangement and substitution reactions (1972)

Reissert anion alkylation has led to a new synthesis of petaline, and a 1-benzoyl-8-hydroxyisoquinoline derivative has been obtained by rearrangement of the corresponding 8-benzoyloxy Reissert compound. Competitive reactions of the anion of 3-methylisoquinoline Reissert compound are described.
A Pockels-effect light valve: Phototitus. Applications to optical image processing (1973)

An electrooptic light valve is described, using the Pockels effect in a KD <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> PO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> crystal cooled close to its Curie temperature and addressed by photoconduction in an amorphous selenium layer. The preliminary performance levels obtained are: resolution 40 lp/mm, maximum contrast ratio 70/1, writing time 10 µs, sensitivity <100 erg/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for 10/1 contrast, and a maximum modulation emciency of ≃75 percent. The linearity of the Pockels effect allows image addition and subtraction, the latter being obtained by reversing the applied voltage between two exposures. Experiments of first-and second-order image derivation using incoherent light are described, the latter obtained by subtraction of a blurred image from the initial one. The grainless structure of the KD <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> PO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> plate prevents all loss of coherence in coherent optical data processing. Furthermore, suppression of the zero order in the Fourier transform of an image has been obtained by subtracting from that image a uniform one whose amplitude is equal to the average amplitude of the initial image; this results in the suppression of the optical noise introduced by the scattering of the zero-order term in coherent filtering experiments. Character-recognition experiments are described employing a filter hologram previously made using the same device. The high-speed capability of the device would permit the construction of automatic reading systems at least ten times faster than those generally available.
Oriented monolayers of submicron crystals by dynamic interfacial assembly (2012)

Large-area, void-free monolayers of oriented submicron crystals (silicalite-1, 800 nm and hematite, 400 nm) were fabricated on an air–water interface by dynamic interfacial assembly and were transferred onto solid substrates with different properties (porous, hydrophobic, conductive).
Changes in laboratory variables induced by isotretinoin treatment of acne (1986)

During a trial of isotretinoin (0.5 mg/kg body weight/day for 3 months) in 90 patients with severe acne, the leucocyte (WBC) count, and particularly the number of neutrophils, decreased significantly. In patients with a good response the mean WBC count fell by 24% and the neutrophils by 33%, whereas in those with a poor response these variables decreased by 8% and 14%, respectively. The serum ALAT, ASAT, cholesterol and triglyceride levels increased significantly. Patients with a poor response (n = 35) received a higher dosage (0.75 mg/kg) for an additional 3 months, and during this period there was a further decrease in the WBC and neutrophil counts and an increase in the triglyceride level. In the other patients, who initially responded well, the dosage was decreased to 0.1 or 0 mg/kg during the second 3-month period, which resulted in reversion of the laboratory variables to the pre-treatment levels. The observed changes were clearly both dose-dependent and reversible.
The involvement of tumor necrosis factor in immunity to Salmonella infection (1991)

The role of TNF in immunity to Salmonella in mice was studied. Antiserum specific for murine TNF was raised and used to neutralize TNF activity in vivo. Injection of this serum into mice infected with the moderately mouse virulent Salmonella typhimurium strain M525 caused exacerbation of disease. Such treatment had no effect on the course of an infection with an attenuated S. typhimurium aroA (strain SL3261) mutant. However, the protection afforded by immunisation with live SL3261 against challenge with the virulent parent strain (SL1344) was abolished by anti-TNF antiserum. Interestingly both early (3 wk) immunity and late (10 wk) immunity was neutralized by such treatment. Inasmuch as early immunity is considered to be nonspecific and macrophage-mediated while late immunity is considered to be serotype-specific and T cell mediated, this suggests that TNF plays a role in protection from Salmonellosis in both cases.
Are patients with bipolar disorder and comorbid attention‐deficit hyperactivity disorder more neurocognitively impaired? (2017)

Our results, although preliminary, suggest that the BD+ADHD group showed the same neurocognitive profile as pBD patients, most likely reflecting the same neurobiological basis. On the other hand, the pADHD group showed a more selective moderate impairment in attention.
Harmonically forced enclosed swirling flow (2009)

The response of steady state vortex flows in an enclosed circular cylinder driven by the harmonic modulation of the rotating end wall is investigated experimentally and numerically. Three dynamic regimes have been identified, with a continuous variation in forcing frequency between them. For very low forcing frequency, the synchronous flow approaches quasistatic adjustment, and for very large forcing frequencies the oscillations in the synchronous flow are localized in the boundary layers on the various cylinder walls. These localized wall oscillations drive the synchronous flow in the cylinder interior to the underlying axisymmetric steady basic state. The third regime occurs for forcing frequencies in the range of the most dangerous axisymmetric Hopf eigenfrequencies, with the 1:1 resonances leading to greatly enhanced oscillation amplitudes localized in the axis region where the flow manifests vortex breakdown recirculation zones.
FINAL REPORT ON IMAGE TUBE DESIGN (1963)

Considerations in image tube design and the design of an actual tube are discussed. Technological considerations (photocathode activation and preparation of the glass envelope and its components) are also described. Results obtained with fifteen tubes and problems encountered with each tube are listed. Remarks on photocathode sensitivity and resolution and suggestions for future work are included. The tube designed and developed shows promise as the first intensifier in a detector chain. The basic electron optical design also has great possibilities. An internally processed cathode has more advantages than the externally processed cathode, and the use of flber optics as the interstage coupler has advantages over a thin glass membrane. (D.C.W.)
MR venography of multiple sclerosis. (2000)

With MR venography, the perivenous distribution of MS lesions in the brain can be visualized in vivo. The venous anatomy defines the typical form and orientation of these lesions.
Über die Reaktion sekundärer Amine mit Lithiumtetrahydridoaluminat (1988)

Abstract Lithium-tris(diethylamino)hydridoaluminate, Lithium-bis(diisopropylamino)dihydridoaluminate. Lithium(tetramethylpiperidino)trihydridoaluminate, NMR Spectra, X-Ray Reactions of diethylamine, diisopropylamine and 2,2,6,6-tetramethylpiperidine with LiAlH 4 in various ethers have been studied. Only two well-defined products result from Et 2 NH, namely LiAlH(NEt 2 )- and LiAl(NEt 2 ) 4 . If molar ratios of Et 2 NH:LiAlH 4 smaller than 3:1 are employed all compounds of the series LiAlH 4-n (NEt 2 ) n (n = 0, 1, 2, 3) are present in solutions of tetra-hydrofuran and diglyme. In diethylether insoluble materials consisting predominantly of lithium diethylaminohydridoaluminates and, presumably, small quantities of Li 3 AlH 6 are also formed. At ambient temperature diisopropylamine reacts slowly with LiAlH 4 , and LiAlH 2 (N i Pr 2 ) 2 can be isolated as a well-defined substitution product. 2,2,6,6-tetramethylpiperidine (tmpH) replaces only a single hydride from LiAlH 4 with formation of LiAlH 3 (tmp). The reactions have been monitored by 7 Li, 13 C and 27 Al NMR spectroscopy, and the structure of LiAlH(NEt 2 ) 3 has been determined by X-ray analysis. The monoclinic compound contains chains of AlHN 3 and LiHN 3 tetrahedra linked through common edges.
The Systemic Theory of Living Systems. Part IV: Systemic Medicine—The Praxis (2005)

This fourth lecture illustrates the praxis and results of Systemic Medicine (SM) in various therapeutic applications. SM's success has made it popular throughout Venezuela and Puerto Rico. The treatment of over 300,000 patients by 150 orthodox MD's, trained and qualified in SM, in 35 medical establishments with above average results corroborate its effectiveness as an eCAM in chronic degenerative diseases. Herein we provide a synopsis of results obtained in four such pathologies-the journal's necessary space restrictions somewhat limiting content-as well as clinical and photographic evidence. The validity of any medical theory is substantiated by its degree of effectivity and success. The workability of evidence-based SM corroborates Systemic Theory's transcendence.
Galactic Bulge Formation as a Maximum Intensity Starburst (1999)

Properties of normal galactic star formation, including the density dependence, threshold density, turbulent scaling relations, and clustering properties, are applied to the formation of galactic bulges. One important difference is that the bulge potential well is too deep to have allowed self-regulation or blow-out by the pressures from young stars, unlike galactic disks or dwarf galaxies. As a result, bulge formation should have been at the maximum rate, which is such that most of the gas would get converted into stars in only a few dynamical time scales, or ~10^8 years. The gas accretion phase can be longer than this, but once the critical density is reached, which depends primarily on the total virial density from dark matter, the formation of stars in the bulge should have been extremely rapid. Such three-dimensional star formation should also have formed many clusters, like normal disk star formation today. Some of these clusters may have survived as old globulars, but most got dispersed, although they might still be observable as concentrated streams in phase space.
A Simple Micro Volumetric Combustion Polarographic Cell (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Simple Micro Volumetric Combustion Polarographic CellR. M. ParkhurstCite this: Anal. Chem. 1961, 33, 2, 320Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://pubs.acs.org/doi/10.1021/ac60170a060https://doi.org/10.1021/ac60170a060research-articleACS PublicationsRequest reuse permissionsArticle Views13Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Einmalgabe von 2g Mesalazin Retardgranulat (Pentasa® Xtend Sachet) versus 1g zweimal täglich zur Remissionserhaltung der Colitis ulcerosa: überlegene Wirksamkeit, bessere Akzeptanz und Compliance (2008)

Einleitung: Die Compliance bei Colitis ulcerosa (CU) Patienten in Remission hinsichtlich einer Mesalazin-Einnahme ist nicht optimal, u.a. bedingt durch die mehrfach tägliche notwendige Einnahme mehrerer Dosen. Non-Compliance führt zu deutlich erhöhten Rezidivraten bei CU. In dieser Studie wurden die Wirksamkeit, Akzeptanz und Compliance bei CU-Patienten in Remission untersucht, die 2g Mesalazin Retardgranulat entweder als einmal tägliches 2g Sachet oder zweimal tägliches 1g Sachet erhielten.
Methodological Aspects of the High-energy Synchrotron X-ray Diffraction Technique for Internal Stress Evaluation (2002)

Abstract The availability of high-energy X-rays from 3rd-generation synchrotron sources offers new approaches to study internal stresses in the bulk of crystalline materials. A method with a wide application potential is the transmission technique introduced by Daymond and Withers, which however has so far been limited to fine-grained materials. In the present work, the reasons for the currently existing limitations are discussed and a viable strategy to extend the technique to samples with coarser grain sizes is proposed.
Topological Materials: Criteria for Realizing Room‐Temperature Electrical Transport Applications of Topological Materials (Adv. Mater. 50/2020) (2020)

The unusual properties exhibited by topological materials, such as 1D edge states that are spin-polarized, can enable routes to faster data processing with lower energy consumption. To realize such technologies, however, it is required that unwanted parallel bulk conduction through the trivial 2D/3D states is eliminated. In article number 2005698, Matthew Brahlek shows that redesigning materials at the atomic level to delicately balance bandgap, dielectric constant, and effective mass is critical to achieve this new generation of quantum-based technologies.
Interaction of Proteins with Partially Depurinated and Depyrimidinated Oligonucleotides (Missing-Contact Probing of Protein-DNA Interactions) (1991)

The procedure first reported by Majors (Majors, 1976, cited by Brunelle and Schleif, 1987) and developed by Brunelle and Schleif (1987) involves the binding of a defined protein to a partially depurinated or depyrimidinated end-labelled oligonucleotide (see Fig. 1). From the mixture of modified DNA oligonucleotides, the protein only binds to those where the bases required for the specific amino acid base contact are intact. As seen in Fig. 1, bases 3 and 4 are important for binding of the protein, whereas bases 1, 2 and 5 may be removed without affecting formation of the protein-DNA complex. This situation is reflected in the final PAGE analysis on a sequencing gel. However, meaningful interpretation of the data from such an experiment assumes that the absence of a base causes no significant structural alteration of the DNA. The essential steps involved in the procedure are shown in the flow diagram in Fig. 2. separation of the protein-DNA complex by gel-shift assay, the DNA is extracted from the gel and subjected to ß-elimination with piperidine. The final reaction products are further separated on a polyacrylamide sequencing gel, which is subsequently autoradiographed on an X-ray film.
Chemical Vapor Deposition Growth. Final Report, December 29, 1975 -- August 31, 1977 (1978)

The objective of this study was to investigate and develop chemical vapor deposition (CVD) techniques for the growth of large areas of Si sheet on inexpensive substrate materials, with resulting sheet properties suitable for fabricating solar cells that would meet the technical goals of the Low Cost Silicon Solar Array (LSSA) Project. The results of 20 months of experimental work are summarized. The program involved six main technical tasks: (1) modification and test of an existing vertical-chamber CVD reactor system; (2) identification and/or development of suitable inexpensive substrate materials; (3) experimental investigation of CVD process parameters using various candidate substrate materials; (4) preparation of Si sheet samples for various special studies, including solar cell fabrication; (5) evaluation of the properties of the Si sheet material produced by the CVD process; and (6) fabrication and evaluation of experimental solar cell structures by OCLI, using impurity diffusion and other standard and near-standard processing techniques, supplemented late in the program by the in situ CVD growth of n exp + /p/p exp + sheet structures subsquently processed into experimental cells. The principal CVD process used was silane (SiH sub 4 ) pyrolysis, although a few experiments were done with the dichlorosilane (SiH sub 2 Cl sub 2 ) process for Si deposition. The evaluation of various possiblesubstrate materials, the CVD parameter investigations, and the experimental solar cell fabrication and characterization are described in considerable detail. Specific conclusions of the work are discussed, and recommendations for continued investigations in certain areas are given.
Leaf chemical and spectral diversity in Australian tropical forests (2009)

Leaf chemical and spectral properties of 162 canopy species were measured at 11 tropical forest sites along a 6024 mm precipitation/yr and 8.7 degrees C climate gradient in Queensland, Australia. We found that variations in foliar nitrogen, phosphorus, chlorophyll a and b, and carotenoid concentrations, as well as specific leaf area (SLA), were expressed more strongly among species within a site than along the entire climate gradient. Integrated chemical signatures consisting of all leaf properties did not aggregate well at the genus or family levels. Leaf chemical diversity was maximal in the lowland tropical forest sites with the highest temperatures and moderate precipitation levels. Cooler and wetter montane tropical forests contained species with measurably lower variation in their chemical signatures. Foliar optical properties measured from 400 to 2500 nm were also highly diverse at the species level, and were well correlated with an ensemble of leaf chemical properties and SLA (r2 = 0.54-0.83). A probabilistic diversity model amplified the leaf chemical differences among species, revealing that lowland tropical forests maintain a chemical diversity per unit richness far greater than that of higher elevation forests in Australia. Modeled patterns in spectral diversity and species richness paralleled those of chemical diversity, demonstrating a linkage between the taxonomic and remotely sensed properties of tropical forest canopies. We conclude that species are the taxonomic unit causing chemical variance in Australian tropical forest canopies, and thus ecological and remote sensing studies should consider the role that species play in defining the functional properties of these forests.
Observations on the Anatomy and Physiology of the Capillary Blood-Vessels (1837)

Original and Selected Communications from The New England Journal of Medicine — Observations on the Anatomy and Physiology of the Capillary Blood-Vessels — [communicated for the Boston Medical and Surgical Journal]
Results of an interim analysis of a multinational randomized, double-blind, phase III study in patients (pts) with previously treated metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo (CONFIRM 2) (2006)

3508 Background: PTK/ZK is a novel, oral, small molecule, antiangiogenic compound that inhibits tyrosine kinase signaling of all known vascular endothelial growth factor (VEGF) receptors. Methods: 855 pts were randomized to FOLFOX4 plus PTK/ZK (1250 mg, qd), or placebo. Eligibility included histologically or cytologically documented mCRC, pretreatment for metastatic disease with irinotecan/fluoropyrimidine-based chemotherapy, measurable disease by RECIST, PS of 0–2 and adequate organ and bone marrow function. The primary endpoint is overall survival (OS). Secondary endpoints included OS and PFS in high LDH pts (stratifiedbybaseline serum LDH levels > 1.5 × ULN). Results: OS was 12.1 mo in the PTK/ZK arm and 11.8 mo in the placebo arm (HR: 0.94; p=0.511). A pre-planned triangular test suggested a low probability of demonstrating an improvement in OS at the final analysis (4Q 2006). The response rates (CR+PR) were 18.5% in the PTK/ZK arm, 17.5% in the placebo arm. PFS was significantly longer in the PTK/ZK arm (5.5 mo vs. 4.1 mo; HR: 0.83; p=0.026). LDH, usually a poor prognostic factor in mCRC, is predictive of the outcome in the PTK/ZK arm. Pts with high LDH showed a strong improvement in PFS when treated with PTK/ZK (5.6 mo vs. 3.8 mo; HR: 0.63; p<0.001) and an improved OS (9.6 mo vs. 7.5 mo; HR: 0.78; p=0.10). Adverse events (AE) were similar to that of the CONFIRM 1 trial (ASCO 2005). Most frequent grade 3/4 AE associated with PTK/ZK were hypertension (PTK/ZK: 21%; placebo: 5%), diarrhea (16%; 8%), fatigue (14.5%; 6.9%), nausea (11%; 5%), vomiting (9%; 5%), dizziness (9%; 1%). AEs were generally reversible. Thrombotic and embolic events of all grades occurred in 6% (PTK/ZK) vs. 1% (placebo) and 4% vs. 1%, respectively. There was no increase in bowel perforations, hematological toxicities or peripheral neuropathy in the PTK/ZK arm. Conclusions: While the primary endpoint for OS was not met, PTK/ZK improves PFS significantly in the overall population, and shows strong activity in patients with high baseline serum LDH. [Table: see text]
Crs As A Tool For True Amplitude Imaging (2001)

We present a method to obtain a true-amplitude<br>migration and amplitude-versus-angle (AVA) at selected<br>points using the attributes generated by the<br>Common Reflection Surface (CRS) Stack. Our approach<br>combines the CRS stack/inversion process<br>applied to multicoverage data, together with the<br>use of a kinematic Kirchhoff migration, to achieve<br>true-amplitudes (TA) at assigned depth points of<br>the migrated images. The proposed method consists<br>of the following steps: (i) apply the CRS process<br>to the given multicoverage data; the obtained<br>CRS attributes are next used to produce a simple<br>macro-velocity depth model; (ii) perform an unweighted<br>Kirchhoff migration for imaging purposes<br>only; for selected points on target reflectors in the<br>migrated image, we use the macro-velocity model<br>to determine, by ray tracing, common-reflectionpoint<br>(CRP) gathers that belong to the input data;<br>for these rays, we compute the incident angles and<br>the geometrical spreadings; (iii) go back to CRP<br>gathers and compensate the amplitudes for geometrical<br>spreading. The results permit to construct<br>AVA curves on the assigned CRPs. In summary,<br>our method is designed to aggregate amplitude information<br>on selected points of a reflector, after a<br>purely kinematic image (migration) has been obtained.<br>The method is tested on a synthetic inhomogeneous<br>layered model with good results.
The Client-Clinician Relationship (1975)

Journal Article The Client-Clinician Relationship Get access The Client-Clinician Relationship. Edited by Emerick LL, Hood SBSpringfield, Charles C Thomas, Publisher, 1974, cloth, 115 pp, illus, $8.50 Claudette Finley Claudette Finley Search for other works by this author on: Oxford Academic Google Scholar Physical Therapy, Volume 55, Issue 8, August 1975, Page 925, https://doi.org/10.1093/ptj/55.8.925 Published: 01 August 1975