gebhart/patrepeval huggingface dataset:
POST-TRANSLATIONAL CONTROL OF GENE EXPRESSION IN WORKING MUSCLE 1 (1997)

Post-translational mechanisms controlling gene expression act at steps following condensation of amino acids on the growing nascent polypeptide and throughout the processing and lifetime of a protein. This often overlooked but emerging area of research on the cellular regulation of functional protein expression following synthesis is important for plastic tissues, such as muscle, because this added level of control can act both independently of transcriptional and translational mechanisms and in a coordinately regulated/regulatory fashion. This symposium will address topics falling into two general categories: control of expression by functional group covalent modification and control of expression through proteolytic cleavage. Specifically, topics will include covalent modification as a means of functional protein activation, especially with regard to feedback mechanisms controlling other levels of gene expression. In addition, the discussion of proteolytic mechanisms will address control of maturation and the ultimate demise of proteins as an adaptational response. Necessarily broad in scope, this symposium is intended to expose the exercise scientist to the possibilities of post-translational adaptation as a control mechanism of gene expression and provide a “flavor” of research directions that may be fruitful.
Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain. (1994)

Hemorrhagic injury induces both 92-kd type IV collagenase/gelatinase and 40-kd urokinase-plasminogen activator expression in brain. We propose that metalloproteinases and serine proteases take part in a proteolytic cascade that breaks down extracellular matrix, opening the blood-brain barrier with secondary brain edema and cell death.
Simulation, Experimental Investigation and Control of Thermal Behavior in Modular Tool Systems (2004)

This chapter contains sections titled: Introduction Investigated Tool Mountings Project Realization Determination of Replacement Heat-transmission Coefficient for Component Joints in a FE Model Building of the Test Stand for Tool Investigations with Fixed Shaft Thermographic Investigations Maximal Correlation and Optimal Transformations Reconstruction of Thermally Induced Displacements in Finite-element Models Reconstruction of Thermally Induced Displacements in Real Data The Thermal Behavior of a Modular Tool System in a Working Milling Machine Conclusion Bibliography
Sterilization and family planning. (1970)

Medico-legal problems can be avoided if both husband and wife are aware of the effects of surgical sterilization and if they give full written consent for the operation. Operations on the fallopian tubes include tubal ligation (Madlener operation) tubal resection (Pomeroy or Irving methods) cornual resection of the uterus fimbriectomy and laparoscopic sterilization. Hysterectomy castration and ovariotexy are other female surgical methods of contraception and male sterilization may be achieved by vasectomy. Indications for sterilization may be therapeutic eugenic or social while complications of sterilization may be anesthetic surgical post-operative gynecological or psychiatric.
The Pilot's Role in the Automated ATC System (1982)

<div class="htmlview paragraph">The conversion from the labor-intensive air traffic control system of today to the virtually completely automated system of tomorrow introduces many benefits, but there are also potential hazards. A concept - “distributed monitoring” - is introduced which will make this transition safer and more efficient. Through this concept, the pilot will play a key role in his operation within the ATC system aided by an on-board cockpit display of traffic information.</div>
The use of aspirin to prevent heterotopic ossification after total hip arthroplasty. A preliminary report. (1991)

The reported incidence of heterotopic ossification (HO) after total hip arthroplasty (THA) ranges up to 50%. HO causes pain and restricted range of motion (ROM) in a significant number of these THA patients. From 1983 to 1988, 177 primary cemented THAs were performed in 131 consecutive patients. Six hundred fifty milligrams of buffered aspirin administered twice daily for two weeks was used as a prophylaxis for thromboembolic disease. There was an unusually low incidence of HO in this group of patients. Aspirin treatment was instituted the night before surgery and continued for two weeks, except in 13 patients (7%) who had to stop treatment because of gastrointestinal symptoms. All patients had at least one year of roentgenographic study postoperatively. According to the Brooker Classification of HO, there were 169 (96%) Grade I and Grade 0 hips, six (3%) Grade II, two (1%) Grade III, and no Grade IV. None of the patients had symptomatic restriction of ROM attributable to heterotopic bone. Aspirin is a safe and inexpensive agent for prevention of HO after THA.
SweetDeal: Representing Agent Contracts with Exceptions Using Semantic Web Rules, Ontologies, and Process Descriptions (2004)

This paper addresses the problem of how to represent exception-handling provisions in automated knowledge-based e-contracts. In many natural language contracts, such provisions constitute the majority of the contract volume. The paper makes three novel contributions. (1) The rule-based SweetDeal e-contracting approach is extended to incorporate ontology knowledge (specifically, ontologies about business processes), and an application scenario about late delivery in manufacturing supply-chain management shows how it can be used to represent provisions for exception-handling. The contract rules are represented in the Situated Courteous Logic Programs knowledge representation encoded in RuleML, the leading approach to Semantic Web rules. The process ontologies are represented in description logic encoded in DAML+OIL, close predecessor of W3C's OWL, the leading approach to semantic Web ontologies. This system is the first to combine these emerging semantic Web standards with one another and for a practical e-business application domain. (2) A simple new technical mechanism for the semantic Web is presented that integrates ontology knowledge with rule knowledge: Rule predicates are defined by reference to ontological classes or properties. (3) Process ontology knowledge drawn from the MIT Process Handbook, a large repository used by practical industrial process designers, is represented in DAML+OIL/OWL, and some of this knowledge is formalized and used for the e-contracting application scenario. Stated more generally, the approach in this paper provides a foundation for representing and automating deals about services--in particular, for helping to search, select, and compose semantic Web services.
Fast Universalization of Investment Strategies with Provably Good Relative Returns (2002)

A universalization of a parameterized investment strategy is an online algorithm whose average daily performance approaches that of the strategy operating with the optimal parameters determined offline in hindsight. We present a general framework for universalizing investment strategies and discuss conditions under which investment strategies are universalizable. We present examples of common investment strategies that fit into our framework. The examples include both trading strategies that decide positions in individual stocks, and portfolio strategies that allocate wealth among multiple stocks. This work extends Cover's universal portfolio work. We also discuss the runtime efficiency of universalization algorithms. While a straightforward implementation of our algorithms runs in time exponential in the number of parameters, we show that the efficient universal portfolio computation technique of Kalai and Vempala involving the sampling of log-concave functions can be generalized to other classes of investment strategies.
Electrochemistry and Dynamic Ionography of Self-Propagating High-Temperature Synthesis (SHS) (2007)

The results of a new potentiometric technique for in situ diagnostics of self-propagating high-temperature synthesis (SHS) of different complex oxides are presented. This technique is based on electrochemical processes. The characteristic peaks attributed to the electric responses from cation streams of alkali, alkaline-earth and some elements of group VI are discovered and the respective routes of the corresponding chemical reactions found.
Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma (2015)

Abrogation of errant signaling along the MAPK pathway through the inhibition of B-RAF kinase is a validated approach for the treatment of pathway-dependent cancers. We report the development of imidazo-benzimidazoles as potent B-RAF inhibitors. Robust in vivo efficacy coupled with correlating pharmacokinetic/pharmacodynamic (PKPD) and PD-efficacy relationships led to the identification of RAF265, 1, which has advanced into clinical trials.
Stimuli that induce a yeast heat shock gene fused to beta-galactosidase. (1984)

Saccharomyces cerevisiae contain a multigene family related to the Drosophila heat shock gene hsp70. Two members of this family, YG100 and YG101, have been previously characterized (Ingolia et al., Mol. Cell. Biol. 2:1388-1398, 1982), and only YG100 was found to have elevated levels of transcription after heat shock. The yeast hsp70 genes contained on YG100 and YG101 were truncated and fused to the Escherichia coli lacZ gene contained on pMC1587 (Casadaban et al., Methods Enzymol. 100:283-308, 1983). The resulting plasmids directed synthesis of the beta-galactosidase gene as measured by in vitro enzyme assays and by colorimetric assays on plates. The expression level from the YG101 gene was constant under all the conditions tested, whereas expression driven by the YG100 gene could be induced over 50-fold. Other stimuli besides heat, including recovery from anoxia and high cell density, were found to strongly induce YG100 gene expression. Most physical and chemical stimuli tested, including UV irradiation, zymolyase treatment, and ethanol, did not stimulate expression of this heat shock gene.
Effect of vesicle size on the polymerization of a diacetylene lipid (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of vesicle size on the polymerization of a diacetylene lipidBrian M. Peek, John H. Callahan, Krishnan Namboodiri, Alok Singh, and Bruce Paul GaberCite this: Macromolecules 1994, 27, 1, 292–297Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ma00079a043https://doi.org/10.1021/ma00079a043research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A supercritical airfoil experiment (1994)

The purpose of this investigation is to provide a comprehensive data base for the validation of numerical simulations. The objective of the present paper is to provide a tabulation of the experimental data. The data were obtained in the two-dimensional, transonic flowfield surrounding a supercritical airfoil. A variety of flows were studied in which the boundary layer at the trailing edge of the model was either attached or separated. Unsteady flows were avoided by controlling the Mach number and angle of attack. Surface pressures were measured on both the model and wind tunnel walls, and the flowfield surrounding the model was documented using a laser Doppler velocimeter (LDV). Although wall interference could not be completely eliminated, its effect was minimized by employing the following techniques. Sidewall boundary layers were reduced by aspiration, and upper and lower walls were contoured to accommodate the flow around the model and the boundary-layer growth on the tunnel walls. A data base with minimal interference from a tunnel with solid walls provides an ideal basis for evaluating the development of codes for the transonic speed range because the codes can include the wall boundary conditions more precisely than interference connections can be made to the data sets.
Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains (2008)

A key effector of the canonical Wnt pathway is beta-catenin, which binds to TCF/LEF factors to promote the transcription of Wnt target genes. In the absence of Wnt stimulation, beta-catenin is phosphorylated constitutively, and modified with K48-linked ubiquitin for subsequent proteasomal degradation. Here, we identify Trabid as a new positive regulator of Wnt signaling in mammalian and Drosophila cells. Trabid show a remarkable preference for binding to K63-linked ubiquitin chains with its three tandem NZF fingers (Npl4 zinc finger), and it cleaves these chains with its OTU (ovarian tumor) domain. These activities of Trabid are required for efficient TCF-mediated transcription in cells with high Wnt pathway activity, including colorectal cancer cell lines. We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription. Epistasis experiments indicate that Trabid acts below the stabilization of beta-catenin, and that it may affect the association or activity of the TCF-beta-catenin transcription complex. Our results indicate a role of K63-linked ubiquitin chains during Wnt-induced transcription.
Composition- and Structure-Tunable Gold–Cobalt Nanoparticles and Electrocatalytic Synergy for Oxygen Evolution Reaction (2016)

The increasing energy crisis constitutes an inspiring drive seeking alternative energies such as hydrogen from water splitting which is clean and abundant, but a key challenge for water splitting is the need of highly efficient catalysts for oxygen evolution reaction (OER). This report describes findings of an investigation of the synthesis of gold-cobalt (AuCo) nanoparticles by a facile one-pot and injection method and their use as highly efficient catalysts for OER. While particle size depends on the synthesis method, the composition of the nanoparticles is controlled by feeding ratio of Au and Co precursors in the synthesis. Depending on Co content, the nanoparticles exhibit largely phase-segregated domains with a core (Au)-shell (Co) type of structure at a high level of Co. Upon the thermochemical treatment of carbon-supported AuCo nanoparticles, the redox activity of Co species in the nanoparticles with cycle number is shown to decrease which changes the surface oxidation state of Co species without changing the composition significantly. The electrocatalytic activity for OER in alkaline electrolytes is shown to depend on the bimetallic composition, displaying a maximum activity for an Au:Co ratio of ∼2:3. This dependence is also shown to correlate with the surface oxidation state and redox activities, providing an insight into the electrocatalytic activity. Mechanistic aspects of the electrocataltytic properties are discussed in terms of the bifunctional synergy of Co and Au in the nanoparticle catalysts.
Oxidation and Oxidative Reactions (2015)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTOxidation and Oxidative ReactionsDavid Lathbury* and Andy Wells*Cite this: Org. Process Res. Dev. 2015, 19, 11, 1536Publication Date (Web):November 20, 2015Publication History Published online20 November 2015Published inissue 20 November 2015https://pubs.acs.org/doi/10.1021/acs.oprd.5b00341https://doi.org/10.1021/acs.oprd.5b00341editorialACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1446Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (113 KB) Get e-AlertscloseSUBJECTS:Oxidation,Oxidation reactions,Physical and chemical processes,Protective groups,Reagents Get e-Alerts
Determining the optimal timing for radical cystectomy after neoadjuvant chemotherapy. (2015)

339 Background: We present the largest series reviewing complications and pathologic outcomes following neoadjuvant chemotherapy (NAC) and radical cystectomy (RC), to determine whether the interval between chemotherapy and surgery (ICS) affects 90-day post-operative morbidity and lymph node metastasis. Methods: We analyzed 338 patients treated with NAC followed by RC from January 1995 through December 2013. The association of ICS with 90-day surgical morbidity, incidence of major complication, 90-day readmission, and lymph node metastasis was determined. Generalized linear models were used to determine potential predictors of each endpoint. Patients were stratified into four groups by ICS days (18 – 42; 43 – 64; 64 – 85; > 85). Complications were classified using the Clavien system. Results: The overall morbidity of the cohort was 59%, with 66% being minor, and 34% being major complications. The median ICS was 46 days (18 – 199 days). There was no difference in the overall morbidity, readmission, or major complication rates among the four groups. Patients with an ICT > 85 days had the highest incidence of lymph node metastasis (40%), though this was not found to be significant (p = 0.1). On multivariate analysis including predictors of perioperative morbidity, extravesical (pT 3 – 4 ) disease (OR = 1.97; p = 0.01) was an independent predictor of overall morbidity, while age at cystectomy (OR = 1.05; p = 0.004), and surgical time ≥ 7 hrs (OR = 2.87; p = 0.001) were independent predictors of major complications. Only surgical time ≥ 7 hrs (OR = 2.24; p = 0.006) was found to be a predictor of readmission. In a separate multivariate analysis that included risk factors for pathological node positivity, the predictors for lymph node metastasis included variant histology (OR = 2.06; p = 0.026) and extravesical disease (OR = 2.76; p = 0.002). Patients with an ICT > 85 days had a higher risk of node metastasis though this was not significant. Conclusions: Patients can undergo RC anytime between 2.5 – 12 weeks after NAC with no difference in risk of surgical complications or nodal metastasis.
Ohioensin-A: a novel benzonaphthoxanthenone from Polytrichum ohioense (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOhioensin-A: a novel benzonaphthoxanthenone from Polytrichum ohioenseGuo Qiang Zheng, Ching Jer Chang, Thomas J. Stout, Jon Clardy, and John M. CassadyCite this: J. Am. Chem. Soc. 1989, 111, 14, 5500–5501Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/ja00196a085https://doi.org/10.1021/ja00196a085research-articleACS PublicationsRequest reuse permissionsArticle Views200Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
2.5 GB/s germanium gate photoMOSFET integrated to silicon photonics (2013)

We demonstrate a monocrystalline 1×8 μm germanium gate photoMOSFET integrated with silicon photonic waveguides and grating coupler operating at over 2.5 GB/s at 1550nm.
Quality-of-service management for ip-based mobile networks (2005)

Efficient support for multimedia communication is essential for next generation mobile wireless networks. In order to provide the necessary quality-of-service (QoS) in mobile wireless networks, appropriate signaling has to be defined. Our QoS signaling architecture integrates resource management with mobility management. It is based on a domain resource manager concept and nicely supports different handover types. In particular, our approach supports anticipated handover with pre-reservation of resources before the mobile node is attached to the new access point. The article discusses the protocol design and implementation, in particular integration with mobile IP, and shows the benefit of anticipated handover by measurement results.
Planar 3 × 3 array of GaInAs/InP MQW surface optical modulators grown by gas-source MBE (1988)

Planar two-dimensional semiconductor arrays of optical modulators operating in the region of 1.55μm are reported for the first time. A process is described which uses MBE-grown GaInAs/InP MQW layers, and which gives a high yield of small, low-leakage optical modulators with an absorption change in each device of 3 dB for an applied bias of −30 V.