gebhart/patrepeval huggingface dataset:
A new DMA registration strategy for pinning-based high performance networks (2004)

This paper proposes anew memory registration strategy for supporting Remote DMA (RDMA) operations over pinning-based networks, as existing approaches are insufficient for efficiently implementing Global Address Space (GAS) languages. Although existing approaches often maximize bandwidth, they require levels of synchronization that discourage one-sided communication, and can have significant latency costs for small messages. The proposed Firehose algorithm attempts to expose one-sided, zero-copy communication as a common case, while minimizing the number of host-level synchronizations required to support remote memory operations. The basic idea is to reap the performance benefits of a pin-everything approach in the common case (without the drawbacks) and revert to a rendezvous-based approach to handle the uncommon case. In all cases, the algorithm attempts to amortize the cost of synchronization and pinning over multiple remote memory operations, improving performance over rendezvous by avoiding many handshaking messages and the cost of re-pinning recently used pages. Performance results are presented which demonstrate that the cost of two-sided handshaking and memory registration is negligible when the set of remotely referenced memory pages on a given node is smaller than the physical memory (where the entire working set can remain pinned), and for applications with larger working sets the performance degrades gracefully and consistently outperforms conventional approaches.
Finite-state machine embeddings for non-concurrent error detection and identification (2004)

In digital sequential systems that operate over several time steps, a state-transition fault at any time step during the operation of the system corrupts its state in a way that can render its future functionality useless. In this paper, we develop a methodology for systematically constructing redundant finite-state machines so that an external checker can capture transient state-transition faults via checks that are performed in a non-concurrent manner (e.g., periodically). More specifically, the proposed approach allows the checker to detect and identify errors due to past state-transition faults based on an analysis of the current, possibly corrupted FSM state. As a result, the checker in such designs can operate at a slower speed than the rest of the system which relaxes the stringent requirements on its reliability.
Enhancing cheese yield by phospholipase treatment of cheese milk (2006)

Udgivelsesdato: JUL
Fixed Routes (1984)

In this paper we consider the fixed routes problem, which is the problem of designing routes for delivery vehicles that can be operated unchanged for a given period of time. We show how standard vehicle routing algorithms can be adapted to deal with the daily version of this problem. Computational results are presented for these adapted algorithms for a number of test problems drawn from the literature.
Clinicopathological Characteristics and Her-2/neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma (2010)

Objective. To analyze clinico-pathological features of Chinese patients with UPSC, and investigate roles of Her-2/neu protein expression and gene amplification in UPSC prognosis. Methods. Thirty-six patients with UPSC treated in Cancer Hospital of Fudan University from 1996 to 2006 were analysed retrospectively. Chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) were performed to evaluate Her-2/neu gene amplification and protein expression respectively. Results. The median age was 63 years, and 61% (22/36) were late stages (stage III/IV). The 1-year, 3-year, and 5-year overall survival (OS) was 73.1%, 51.9% and 43.9%, respectively. Advanced stages (P = .0006) and deep myometrial invasion (P = .0138) were significantly associtated with a shorter OS. In 36 cases, 27.8% (10/36) showed 2+ staining and 8.3% (3/36) showed 3+ by IHC. Amplification of the Her-2/neu gene was observed in 11.1% (4/36) cases. The 5-year overall survival rate in Her-2/neu IHC 2 + ∼3+ and 0 ~ 1+ cases was 12.9% and 68.6% respectively. Her-2/neu protein expression 2 + ∼3+ was significantly associated with advanced surgical stage and worse overall survival (P = .03 and P = .0023, resp.). Conclusion. Chinese patients with UPSC showed characteristics of deep myometrial invasion, advanced stages and poor overall survival. Her-2/neu protein overexpression is associated with advanced stage and poor survival outcome.
Distance Separated Simultaneous Sweeping: efficient 3D Vibroseis acquisition in Oman (2010)

Distance Separated Simultaneous Sweeping (DS3) is one of a number of techniques developed by BP for efficient land seismic operations. DS3 relies on the Vibroseis source separation distance being chosen to allow sufficient travel time such that the first break noise, or reflection signal, will reach the midpoint crossover later than the time of interest for target horizons. The DS3 records are thus uncontaminated by simultaneous source noise for all levels down to, and including, the target horizon. Implemented at field wide scale across Block 61 in Oman, the DS3 technique achieved world record acquisition production rates and produced excellent data quality.
Multilayer Formation in Thin Films of Thermotropic Liquid Crystals at the Air-Water Interface (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultilayer Formation in Thin Films of Thermotropic Liquid Crystals at the Air-Water InterfaceMarc N. G. de Mul and J. Adin Mann Jr.Cite this: Langmuir 1994, 10, 7, 2311–2316Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/la00019a048https://doi.org/10.1021/la00019a048research-articleACS PublicationsRequest reuse permissionsArticle Views616Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: STUDY ON NEW DIRECT AZO DYES. DYES FROM 2‐(P‐AMINOPHENYL)‐, 2,5‐BIS(P‐AMINOPHENYL)‐ AND 2,5‐BIS(P‐AMINOSTYRYL)THIOPHENE: DYEING THERMODYNAMICS, METALLIZATION, CIE MEASUREMENT (1979)

Abstract Der Übersichtsartikel (29 Literaturhinweise) behandelt die Messung und Beschreibung coloristischer Eigenschaften einiger direkter Azofarbstoffe auf Baumwolle und Viskoserayon.
Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 6. Study of the 5-HT<sub>1A</sub>/α<sub>1</sub>-Adrenergic Receptor Affinity by Classical Hansch Analysis, Artificial Neural Networks, and Computational Simulation of Ligand Recognition (2000)

A classical quantitative structure-activity relationship (Hansch) study and artificial neural networks (ANNs) have been applied to a training set of 32 substituted phenylpiperazines with affinity for 5-HT(1A) and alpha(1)-adrenergic receptors, to evaluate the structural requirements that are responsible for 5-HT(1A)/alpha(1) selectivity. The resulting models provide a significant correlation of electronic, steric, and hydrophobic parameters with the biological affinities. Although the derived linear Hansch correlations give good statistics and acceptable predictions, the introduction of nonlinear relationships in the analysis gives more solid models and more accurate predictions. In the ANN models on the basis of the obtained 3D plots, the 5-HT(1A) affinity has a nonlinear dependence on F, V(o), V(m), and pi(o), although the nonlinear relationship is not far from a planar one. The alpha(1)-adrenergic receptor affinity has a clear nonlinear dependence on F, V(o), V(m), pi(o), and pi(m). A comparison of both analyses gives an additional understanding for 5-HT(1A)/alpha(1) selectivity: (a) high F values increase the binding affinity for 5-HT(1A) receptors and decrease the affinity for alpha(1) sites; (b) the hydrophobicity at the meta-position has only influence for the alpha(1)-adrenergic receptor; (c) the meta-position seems to be implicated in the 5-HT(1A)/alpha(1) selectivity. While the 5-HT(1A) receptor is able to accommodate bulky substituents in the region of its active site, the steric requirements of the alpha(1)-adrenergic receptor at this position are more restricted. This information was used for the design of the new ligand EF-7412 (33) (5-HT(1A): K(i exptl) = 27 nM, alpha(1): K(i exptl) > 1000 nM; 5-HT(1A): K(i pred) (ANN) = 36 nM, alpha(1): K(i pred ANN) = 2745 nM) which was characterized as an antagonist in vivo in pre- and postsynaptic 5-HT(1A)R sites. Computational simulations of the complex between EF-7412 (33) and a 3D model of the transmembrane domain of the 5-HT(1A) receptor allowed us to define the molecular details of the ligand-receptor interaction that includes: (i) the ionic interaction between the protonated amine of the ligand and Asp 3.32; (ii) the hydrogen bonds between the m-NHSO(2)Et group of the ligand and Asn 7.39; and the hydrogen bonds between the hydantoin moiety of the ligand and (iii) Thr 3.37, (iv) Ser 5.42, and (v) Thr 5.43. These QSAR and ANN results in combination with computational simulations of ligand recognition will be useful for the design of potent selective 5-HT(1A) ligands.
La fluorescence de résonance : Etude par la méthode de l’atome habillé (1983)

Resonance fluorescence consists of photon absorption and photon reemission by an atom interacting with a monochromatic, resonant and intense laser wave. The aim of this paper is to show that all fluorescence signals can be quantitatively calculated through the dressed atom method and that simple physical pictures can be associated to the results obtained in this manner. In such a method, the compound system «atom plus laser photons interacting together» (atom dressed by the laser photons) is first considered and the emission of fluorescence photons is then included as a radiative relaxation of this new quantum system. Emission frequencies thus appear as allowed Bohr frequencies of the dressed atom and Rabi nutation appears as a quantum beat signal between dressed states. Photon correlation and photon counting signals are well understood when fluorescence is considered as a radiative cascade of the dressed atom downwards its energy diagram. Mixed analysis time-frequency, for example study of temporal correlations between photons emitted in some sidebands of the fluorescence spectrum, is suggested by the dressed atom approach. Finally, when compared with the well known optical Bloch equations method, the dressed atom is shown to have a larger validity domain for the Markov approximation On montre que la methode de l'atome habille permet un calcul quantitatif de tous les signaux de fluorescence et associe les resultats a des interpretations physiques simples. Discussion des resultats et presentation des avantages de cette methode
Rates and Patterns of Molecular Evolution in Inbred and Outbred <i>Arabidopsis</i> (2002)

The evolution of self-fertilization is associated with a large reduction in the effective rate of recombination and a corresponding decline in effective population size. If many spontaneous mutations are slightly deleterious, this shift in the breeding system is expected to lead to a reduced efficacy of natural selection and genome-wide changes in the rates of molecular evolution. Here, we investigate the effects of the breeding system on molecular evolution in the highly self-fertilizing plant Arabidopsis thaliana by comparing its coding and noncoding genomic regions with those of its close outcrossing relative, the self-incompatible A. lyrata. More distantly related species in the Brassicaceae are used as outgroups to polarize the substitutions along each lineage. In contrast to expectations, no significant difference in the rates of protein evolution is observed between selfing and outcrossing Arabidopsis species. Similarly, no consistent overall difference in codon bias is observed between the species, although for low-biased genes A. lyrata shows significantly higher major codon usage. There is also evidence of intron size evolution in A. thaliana, which has consistently smaller introns than its outcrossing congener, potentially reflecting directional selection on intron size. The results are discussed in the context of heterogeneity in selection coefficients across loci and the effects of life history and population structure on rates of molecular evolution. Using estimates of substitution rates in coding regions and approximate estimates of divergence and generation times, the genomic deleterious mutation rate (U) for amino acid substitutions in Arabidopsis is estimated to be approximately 0.2-0.6 per generation.
Microwave applications of integrated-circuit techniques (1964)

Low-inductance circuits made by integrated-circuit techniques will permit higher frequency operation of parametric amplifiers and tunnel-diode oscillators. Symmetry can replace some filter circuits, especially in varactor harmonic generators. Interconnections can be based on transmission-line principles and then offer improved bandwidth for limiters and switches. Improved bandwidth is generally expected from integrated-electronic fabrication and will ease tolerances on element parameters.
BLIND SOURCE SEPARATION ALGORITHM FOR MIMO CONVOLUTIVE MIXTURES (2001)

We consider the problem of blind source separation of MIMO convolutive mixtures for the general case where the number of sensors are greater than or equal to the number of sources. We assume that sources are non-stationary signals. The separation is performed in the frequency domain by joint minimization of the o#--diagonal elements of observed signal&apos;s cross-spectral density matrices over di#erent epochs. We propose an e#cient Newton-- based algorithm over the complex Steifel manifold to minimize an appropriate cost function. We resolve the permutation problem using a novel tree structured diadic detection scheme. We find and correct wrong permutations at each frequency bin based on cross frequency correlation between diagonal elements of the output cross spectral matrices. We demonstrate the performance of the new algorithm using synthetic mixtures and real word recordings. The method has the additional advantage of fast convergence.
Combined feedforward-feedback servo control scheme for an exothermic batch reactor (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCombined feedforward-feedback servo control scheme for an exothermic batch reactorArthur Jutan and Ashok UppalCite this: Ind. Eng. Chem. Process Des. Dev. 1984, 23, 3, 597–602Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/i200026a032https://doi.org/10.1021/i200026a032research-articleACS PublicationsRequest reuse permissionsArticle Views318Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The medicolegal investigation of operating room associated deaths. (1977)

For those medicolegal investigative systems charged by statute with the responsibility of investigating and examining known or suspected iatrogenic deaths--whether in a perioperative or operative situation, or in some other relationship to medical intervention--there is usually little doubt that these types of investigations constitute the most difficult, often perplexing, and far-reaching investigation, examination, and reporting problems of any of the types of cases referred. Much of this difficulty derives from the changing attitude of the public at large, including the medical and the legal community. In the United States, as recently as 15 years ago, the loss of life or injury subsequent to a therapeutic or operative procedure, with rare exception, was accepted virtually as an act of God.
Numbers of breeding Little Eagles Hieraaetus morphnoides in the Australian Capital Territory in relation to atlas counts (2013)

The Little Eagle Hieraaetus morphnoides is undergoing a severe decline in parts of south-eastern Australia, including the Australian Capital Territory, even though atlas reporting rates may suggest that Little Eagle numbers are stable or declining only moderately. We compared trends in atlas reporting rates of the Little Eagle, and the number of occupied Little Eagle breeding territories (active nests), in the ACT during 1988 阂2011. We found that, although the number of occupied territories or breeding pairs declined from 13 to one (i.e. >90% decline), the number of reported Eagle sightings  uctuated about a rather constant level. Because atlas surveys may not accurately re ect declines, or the severity of declines, in some raptors, we suggest that atlas data are combined with surveys of nesting raptors to assess trends in raptor numbers.
New Fabrication of Superconducting Flux Detector (1971)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. M. Goodkind, Jeffrey M. Dundon; New Fabrication of Superconducting Flux Detector. Rev Sci Instrum 1 August 1971; 42 (8): 1264–1265. https://doi.org/10.1063/1.1685363 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioReview of Scientific Instruments Search Advanced Search |Citation Search
Quinazoline Antifolates Thymidylate Synthase Inhibitors:  Lipophilic Analogues with Modification to the C2-Methyl Substituent (1996)

Modification of the potent thymidylate synthase (TS) inhibitor 1-[[N-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N- prop-2-ynylamino]benzoyl]amino]methyl]-3-nitrobenzene (4a) has led to the synthesis of quinazolinone antifolates bearing functionalized alkyl substituents at C2. A general synthetic route was developed which involved coupling the appropriate 1-[[N-[4-(alkylamino)benzoyl)amino]methyl]-3-nitrobenzene 20-22 with a 6-(bromomethyl)-2-(acetoxymethyl)-3,4-dihydro-4-oxoquinazoline 9 or 10. Replacement of the 2-acetoxy group by a chlorine atom followed by the displacement of the halogen of 25a-c by various nucleophiles led to compounds 26-40. Good TS (IC50 < 1 microM) and growth inhibition (IC50 0.1-1 microM) were found with most of these new antifolates. TS inhibitors in this series do not apparently require the reduced folate carrier (RFC) for cell entry (they most likely penetrate the cell membrane by passive diffusion) and are not polyglutamated. N, O, S, Cl, and CN as well as large amino and mercapto substituents were tolerated by the enzyme. The simultaneous incorporation of 7-methyl and 2'-F substituents gave a series of highly potent agents inhibiting cell growth at concentrations < 1 microM (24, 27bc; 30-32b, 35b). The incorporation of suitable C2 substituents has overcome the decrease in aqueous solubility observed with lipophilic quinazoline antifolates. This is best illustrated by compound 31a, where up to a 54-fold increase in solubility has been achieved by the incorporation of an N-methylpiperazine nucleus into the C2-methyl group of 4a.
All-optical switching in subwavelength metallic grating structure containing nonlinear optical materials (2008)

All-optical switching based on a subwavelength metallic grating structure containing nonlinear optical materials has been proposed and numerically investigated. Metal-dielectric composite material is used in the switching for its larger third-order nonlinear susceptibility (~10−7esu) and ultrafast response properties. The calculated dependence of the signal light intensity on the pump light intensity shows a bistable behavior, which results in a significant switch effect. It rests on a surface plasmon's enhanced intensity-dependent change of the effective dielectric constant of Kerr nonlinear media, corresponding to a transition of the far-field transmission from a low- to high-transmission state. The study of this switching structure shows great advantages of smaller size, lower requirement of pump light intensity, and shorter switching time at approximately the picosecond level.
Efficacy of Lactobacillus plantarum in prevention of inflammatory bowel disease (2018)

The incidence of inflammatory bowel disease (IBD) is increasing globally. Altered gut bacteria and bacterial metabolic pathways are two important factors in the initiation and progression of IBD. <i>Lactobacillus plantarum</i> is distributed in a variety of ecological niches, has a proven ability to survive gastric transit, and can colonize the intestinal tract of human and other mammals. Several studies have described the effects of <i>L. plantarum</i> consumption on human physiology. This review summarizes the safety and the effects of <i>L. plantarum in vitro</i> and in animal models for the prevention and management of IBD. <i>L. plantarum</i> modulates the ratio of Th1 and Th2 cells by stimulating the production of different inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1β, IL-6, IL-10, IL-12, and interferon-gamma. The blocking of cyclooxygenase-2 in Th1 also is an apoptotic inhibition mechanism. This overview of the molecular studies addresses the activity of <i>L. plantarum</i> in the human gut environment and its' potential for remission of IBD.
An integrated onboard charger and accessory power converter for plug-in electric vehicles (2013)

This paper presents an integrated onboard battery charger and accessory dc-dc converter for plug-in electric vehicles (PEVs). The integrated charger utilizes the already available traction drive inverters and motors in a PEV as the frond converter of the charger circuit and shares the high frequency transformer with the 14V accessory dc-dc converter for providing galvanic isolation. As a result, the integrated charger has lower cost, weight, and volume than a standalone charger. Experimental results on a 5 kW charger prototype are included to verify the topology.