gebhart/patrepeval huggingface dataset:
Hera-JVM: abstracting processor heterogeneity behind a virtual machine (2009)

Heterogeneous multi-core processors, such as the Cell processor, can deliver exceptional performance, however, they are notoriously difficult to program effectively. We present Hera-JVM, a runtime system which hides a processor’s heterogeneity behind a homogeneous virtual machine interface. Preliminary results of three benchmarks running under Hera-JVM are presented. These results suggest a set of application behaviour characteristics that the runtime system should take into account when placing threads on different core types. 1
An open-label randomized phase II trial of belinostat (PXD101) in combination with carboplatin and paclitaxel (BelCaP) compared to carboplatin and paclitaxel in patients with previously untreated carcinoma of unknown primary. (2010)

TPS185 Background: Treatment options for patients (pts) with cancer of unknown primary (CUP) are limited; carboplatin (C) and paclitaxel (P) combination being one of the options. Belinostat (B), is a hydroxamate, class I and II histone deacetylase inhibitor (HDACi) with a broad antineoplastic activity. Phase I and II trials are ongoing in multiple indications and in more than 500 patients the most common adverse events have been nausea, vomiting and fatique. Preclinical data shows synergistic effect when combined with C and P in vitro and in vivo. In a phase I study f or patients with pretreated advanced solid tumors, BelCaP was well-tolerated and active with objective responses seen in pancreatic and rectal cancer pts. A pt with CUP (3 prior chemotherapy regimens) had disease control during 29 mos of treatment. Theref ore, we are conducting a randomized Ph II study (N∼88) of CaP with or without B in CUP pts. Methods: Randomized, global, multicenter phase II trial in 19 centers. Inclusion criteria include: a confirmed diagnosis of CUP, no prior therapy, ECOG PS 0-2, age > 18 years. Eligible patients are randomized to receive either arm A or B. Arm A: BelCaP; B as a 30-min i.v. infusion once daily (1,000 mg/m2) on days 1-3, followed by B 2,000 mg orally once daily on days 4-5, with P (175 mg/m2) administered 2-3 hrs following B on day 3 and C (AUC6) following directly after P, up to 6 cycles. From cycle 7: B 750 mg is administered orally once daily × 14 days. Arm B: P (175 mg/m2) administered day 1 and C (AUC6) following directly after P. Cycles repeated every 3 weeks. Primary endpoint is progression free survival (PFS) and secondary endpoints assess additional efficacy parameters and safety. Response is evaluated according to RECIST criteria. 33 pts have been randomized as of 6 Jan 2009. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration TopoTarget Pfizer Roche, sanofi-aventis TopoTarget
Fentanyl increases cerebrospinal fluid pressure in normocapnic volunteers. (1992)

In a double blind randomized study, the effect of fentanyl 1 microgram kg-1 i.v. or placebo on mean lumbar cerebrospinal fluid pressure (CSFP), mean arterial pressure, cerebral perfusion pressure, transcutaneous PCO2 and heart rate was studied in 10 spontaneously breathing volunteers in the lateral decubitus position via a 22-gauge spinal needle inserted into the subarachnoidal space at level L3/L4. Fentanyl increased mean CSFP (+/- SD) from 12.4 +/- 2.7 mmHg to 16.0 +/- 2.3 mmHg (P < 0.05) without significant changes in the other variables. No significant changes in any of the measured variables were seen after administration of placebo. Cerebral perfusion pressure decreased significantly after fentanyl (P < 0.05).
Comprehensive Review of Patulin Control Methods in Foods (2005)

The mycotoxin, patulin (4-hydroxy-4H-furo [3, 2c] pyran-2[6H]-one), is produced by a number of fungi common to fruit- and vegetable-based products, most notably apples. Despite patulin's original discovery as an antibiotic, it has come under heavy scrutiny for its potential negative health effects. Studies investigating these health effects have proved inconclusive, but there is little doubt as to the potential danger inherent in the contamination of food products by patulin. The danger posed by patulin necessitates its control and removal from foods products, creating a demand for handling and processing techniques capable of doing so, preferably at low cost to industry. With this being the case, much research has been devoted to understanding the basic chemical and biological nature of patulin, as well as its interaction within foods and food production. While past resarch has elucidated a great deal, patulin contamination continues to be a challenge for athe food industry. Here, we review in depth the past research on patulin with an emphasis upon its influence within the food industry, including its regulation, health effects, biosynthesis, detection, quantification, distribution within foods, and control, during the various stages of apple juice production. Finally, key areas where future patulin research should focus to best control the patulin contamination problem within the food industry are addressed.
L'affaire du Lac Lanoux (1957)

Gervais André. L'affaire du Lac Lanoux. In: Annuaire français de droit international, volume 3, 1957. pp. 178-180.
ChemInform Abstract: Chemistry and Structures of Tris(diphenylphosphino)ethene and 1,1,4,4‐Tetrakis(diphenylphosphino)‐1,3‐butadiene. (1989)

Abstract Some reactions of the tris‐phosphino derivative (I), obtained recently by base‐catalyzed hydrophosphorylation of Ph2P‐C≡C‐PPh2 with Ph 2 PH, are demonstrated in the scheme.
An overview of the evaluation of oxygen interaction with materials-third phase (EOIM-III) experiment - Space Shuttle Mission 46 (1993)

An overview of EOIM-III, designed to produce benchmark atomic oxygen reactivity data is presented. Ambient density measurements are conducted using a quadrupole mass spectrometer calibrated for atomic oxygen measurements in a unique ground-based test facility. The combination of these data with the predictions of ambient density models permits an assessment of the accuracy of measured reaction rates on a variety of materials, many of which have never been tested in LEO previously.
Atividade de Cedrela fissilis e Cipadessa fruticosa (Meliaceae) sobre a lagarta-do-cartucho do milho Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) (2010)

A atividade biológica de extratos orgânicos de folhas, galhos e frutos de Cedrela fissilis e de Cipadessa fruticosa (Meliaceae), além do caule e das raízes de C. fissilis foi avaliada sobre Spodoptera frugiperda (J.E. Smith) desenvolvidas em condições laboratoriais. Os extratos orgânicos foram incorporados à dieta artificial na proporção de 100 mg de extrato para 100 g de dieta e oferecidos a S. frugiperda durante seu período larval. Os parâmetros avaliados foram duração e mortalidade das fases larval e pupal e peso das pupas. O extrato diclorometânico de folhas de C. fissilis, que apresentou maior atividade inseticida, no qual ocorreu um alongamento da fase larval, seguido por uma diminuição do peso pupal, além de uma taxa de mortalidade larval de 63,3 %.
Selection and Evaluation of Heat-Resistant Alloys for SOFC Interconnect Applications (2003)

Over the past several years, advances in the design and fabrication of planar solid oxide fuel cells (SOFCs) have led to a steady reduction in the temperatures necessary for their operation. Consequently, it appears more realistic now to use low cost heat-resistant alloys for interconnect components in the SOFC stack. However, no specific criteria or inclusive study are available as a reference to help select and evaluate suitable candidates from the hundreds of available heat-resistant alloy compositions, which overall demonstrate oxidation resistance at high temperatures. In this work, composition criteria have been proposed for the preselection of heat-resistant compositions, such as Ni-, Fe-, and Co-based superalloys, Cr-based alloys, and stainless steels. The proposed criteria have been employed to establish a database of heat-resistant alloys at Pacific Northwest National Laboratory, where a systematic approach has been initiated to evaluate and modify and/or develop alloys for SOFC interconnect applications. The preselected compositions are further evaluated by referring in-house studies and reference to published data. It appears that it would be difficult for traditional alloys to fully satisfy the materials requirements for long-term operation at temperatures higher than 700°C. However, the applicability can be improved via surface/bulk modification and by the implementation of novel stack designs. © 2003 The Electrochemical Society. All rights reserved.
Amplification of Infrared Multiphoton Dissociation Efficiency in a Quadruple Ion Trap Using IR-Active Ligands (2006)

A strategy for increasing the efficiency of infrared multiphoton dissociation (IRMPD) in a quadrupole ion trap (QIT) is described. IR-active ligands (IRALs) are incorporated into noncovalent complexes of the type [M2+(analyte) IRAL]+, where M is a transition metal such as copper or cobalt and IRAL is an auxiliary ligand with an IR-active phosphonate functional group. The complexes are formed via self-assembly in solution directly prior to ESI-MS analysis. We demonstrate this new IRMPD approach for the structural characterization of flavonoids. The fragment ions obtained by IRMPD are similar to those obtained by CAD and allow facile isomer differentiation of flavonoids. Fourier transform infrared absorption attenuated total reflectance (FTIR-ATR) and energy-variable CAD experiments indicate that the high IRMPD efficiencies stem from the very large IR absorptivities of the IR-active ligands.
Synthesis of Tri‐Substituted Vinyl Boronates via Ruthenium‐Catalyzed Olefin Cross‐Metathesis. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Rare Earth Compounds. I. Rare Earth Polysulfides (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRare Earth Compounds. I. Rare Earth PolysulfidesS. A. Ring and Melvin TecotzkyCite this: Inorg. Chem. 1964, 3, 2, 182–185Publication Date (Print):February 1, 1964Publication History Published online1 May 2002Published inissue 1 February 1964https://pubs.acs.org/doi/10.1021/ic50012a006https://doi.org/10.1021/ic50012a006research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Innovative design technology: An optimal surgical aid system for Hip Resurfacing Arthroplasty (2012)

Hip Resurfacing Arthroplasty (HRA) is a treatment option for the patients with the advanced hip disease; it is considered as the most technically difficult techniques of all procedures recommended for osteonecrosis of the hip. Technically, the currently applied HRA surgeries lead to unstable and inconsistent results. Surgeons rely a lot on the manual technique and conventional tools as well as their skills to determine the right drilling angle for locating the implant system. Although the robotic and surgical planning systems are available for HRA, the drilling line is still defined geometrically and intra-operatively, not fully considering about the biomechanics aspects of the implant and bone structure. In this paper, an optimal surgical aid system for HRA is proposed. With the integration of the state of the art biomedical modelling, pre-operative planning and personalised surgical tools, knowledge based and expert system, as well as biomechanics modelling and analysis, the precision, safety and speed of surgery are improved, the complexity of surgery is reduced, and therefore the survival rate of the implant is increased. Especially, the proposed system provides a cheap and practically feasible solution with the integration of expertise from both engineering and medicine for improving the treatment quality of the patients.
Understanding the Educational Needs for Parents of Children With Clubfoot (2011)

The parents' educational needs fell into the following 2 categories: (1) understanding the process of treatment and (2) problems concerning the bracing portion of treatment. Themes exposed the effects on daily living and accommodations made to follow treatment. Parents perceive that the role of the healthcare provider is to present how-to information, specify consequences of the risks, promote awareness, provide encouragement and support, and remind them of positive effects to be expected when treatment is completed.
Theory of Maturation: A Critique (1970)

No AccessJournal of Urology1 Jun 1970Theory of Maturation: A Critique Richards P. Lyon, Sumner Marshall, and Emil A. Tanagho Richards P. LyonRichards P. Lyon More articles by this author , Sumner MarshallSumner Marshall More articles by this author , and Emil A. TanaghoEmil A. Tanagho More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)62051-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1970 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByOSWALD J, BRENNER E, SCHWENTNER C, DEIBL M, BARTSCH G, FRITSCH H and RADMAYR C (2018) The Intravesical Ureter in Children With Vesicoureteral Reflux: A Morphological and Immunohistochemical CharacterizationJournal of Urology, VOL. 170, NO. 6, (2423-2427), Online publication date: 1-Dec-2003.Vermillion C and Healef W (2018) Position and Configuration of the Ureteral Orifice and its relationship to Renal Scarring in AdultsJournal of Urology, VOL. 109, NO. 4, (579-584), Online publication date: 1-Apr-1973.Cass A and Ireland G (2018) Significance of Ureteral Submucosal Tunnel Length, Orifice Configuration and Position in Vesicoureteral RefluxJournal of Urology, VOL. 107, NO. 6, (963-965), Online publication date: 1-Jun-1972. Volume 103Issue 6June 1970Page: 795-800 Advertisement Copyright & Permissions© 1970 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Richards P. Lyon More articles by this author Sumner Marshall More articles by this author Emil A. Tanagho More articles by this author Expand All Advertisement PDF DownloadLoading ...
Comparative Studies of an Orally-active Factor Xa Inhibitor, YM-60828, with other Antithrombotic Agents in a Rat Model of Arterial Thrombosis (1998)

We examined the antithrombotic activity of a novel synthetic inhibitor of factor Xa, YM-60828, in an electrically-induced carotid artery thrombosis model in rats. In the first experiment, the antithrombotic activity of YM-60828 after i.v. infusion was compared with those of heparin, darteparin and argatroban. Test drug was administered by i.v. infusion from 30 min before electrical stimulation to the end of the experiment. YM-60828 at 1 mg/kg/h significantly improved patency status, prolonged the time to occlusive thrombus formation and duration of patency. Heparin at 300 U/kg/h also improved these parameters, but were accompanied by a marked increase in systemic coagulation time. In the second experiment, the antithrombotic activity of YM-60828 after oral administration was compared with those of ticlopidine, cilostazol, aspirin, beraprost, ethyl icosapentate and warfarin. Test drug was orally administered to fasted rats 60 min before electrical stimulation. YM-60828 at 30 mg/kg p.o., but not ticlopidine, cilostazol, aspirin, beraprost, ethyl icosapentate or warfarin, significantly reduced the incidence of occlusion and improved carotid arterial patency. These results suggest that YM-60828 may be a promising antithrombotic agent for the treatment and prevention of arterial thrombosis which can be given by oral as well as intravenous administration.
Dynamic range boosting for wireless optical receivers (2002)

This paper presents a dynamic range boosting technique for wireless optical receivers. This technique changes the feedback impedance of the transimpedance amplifier by the control of multiple parallel transistors in the triode region. This strategy results in a wide controllable gain amplifier, without extra signal-to-noise ratio penalties. A front-end with 20 MHz bandwidth, maximum transimpedance gain of 130 dB /spl Omega/ and a minimum dynamic range of 60 dB is implemented with this technique for wireless optical Ethernet and ATM applications.
Reactions of 5-β-D-Ribofuranosyl Tetrazoles with Dipolarophiles (1991)

Abstract A two step transformation of protected 5-β-D-ribofuranosyl tetrazoles into pyrazole derivatives is described.
Distributed Capacity Based Channel Allocation for Dense Local Area Deployments (2011)

Local area deployments in general and femtocells in particular have proved to be an effective solution for providing ubiquitous coverage in a cost-efficient manner, satisfying the high data rate and QoS requirements for LTE-Advanced systems. In this paper, we investigate inter-cell interference management schemes for dense local area deployments. We propose a distributed capacity based channel allocation scheme where Home Base Stations (HBS) autonomously decide whether to use a carrier or not, based on the capacity improvements gained by using that carrier compared to the capacity loss experienced in neighboring HBSs already using the same carrier. We have also studied centralized schemes to understand how well the distributed schemes are performing. We present numerical results obtained for the proposed schemes which show significant improvements to cell-edge users with almost no compromise in mean throughput.
Regulation of Snai2 by estrogen receptor-alpha and glycogen synthase kinase-3 beta in human breast cancer (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

4402 

Snai2 (Slug), a member of the Snail family of C2H2-type zinc finger transcription factors, represses E-cadherin, a process which mediates in part epithelial-mesenchymal transition (EMT) in human breast cancer. Whereas much is known about the functions of Snai2, little is known about the regulation of this gene. In this study we report that both estrogen receptor alpha (ERα) and glycogen synthase kinase-3beta (GSK-3β) are key activators/regulators of snai2. ERα generally is thought to regulate gene expression by two mechanisms: direct activation/repression or proteolytic degradation of its target gene products through ubiquination pathways. Here, we report that snai2 is a target of ERα by both mechanisms. Our data show that treatment of ERα positive MCF-7 cells with 17-β estradiol (E2) decreases the level of snai2 mRNA and treatment of ERα-positive or negative cells with HDAC inhibitors leads to upregulation of snai2 expression. The snai2 mRNA increases when ERα is knocked down by shRNA in MCF-7 cells. Using the CHIP assay, ERα proteins bind to the upstream region of Snai2 promoter. Furthermore, in MCF-7 cells, N-CoR and SMRT bind to the same region of the snai2 promoter and ERα, N-CoR, SMRT, HDAC1 form a corepressor complex that suppresses the transcription of the snai2 gene. However, in the transgenic MDA-MB-468 cell line which expresses a full-size ERα, the levels of both snai2 mRNA and protein are found to increase, suggesting that ERα regulates snai2 transcription differently in a natively ERα negative line. Our data also show that ERα can bind with snai2 and promote the degradation of snai2 protein by ubiquination. With respect to GSK-3β, this kinase is a key activator of snai2. Using both the ERα negative MDA-MB-468 and -231 cell lines, we observed that the expression of snai2 is downregulated when the cell lines are treated with GSK-3 inhibitors and snai2 expression completely abolished when treated with LiCl, a specific GSK-3β inhibitor, indicating that it is GSK-3β and not GSK-3α, that regulates the expression of snai2. Snai2 expression also decreases when the cell lines are treated with IGF-I, which regulates the MAPK and the PI3K pathways. In contrast, the PI3K inhibitor, wortmannin, and the MAPK inhibitor, PD98059, increase snai2 expression suggesting that the release of suppression of GSK-3β correlates with the upregulation of snai2. We also found TGFβ decreases snai2 expression by suppressing GSK-3β through the MEK/ERK pathway. The same results were obtained from Wnt/frizzled/DSH pathway activation which leads to inhibition of GSK-3β with resulting inhibition of snai2 expression. GSK-3β plays a central and key role in activation of snai2. Predictably extracellular growth factors, such as TGFβ and IGF-I, also decrease snai2 expression through their regulation of GSK-3β. Both ERα and GSK-3β regulate snai2. These findings then link these genes to E-cadherin expression and EMT in human breast cancer.
Visual servoing for a scale model autonomous helicopter (2002)

A control design to stabilise a reduced scale autonomous helicopter equipped with a camera is presented. The proposed algorithm is motivated by recent work in image-based visual servoing control for under-actuated dynamic systems. This work is extended by considering models that contain weakly nonminimum phase zero dynamics. This is an important class of systems since an offset between the camera and the centre of mass for a typical 'dynamic' autonomous vehicle will result in zero dynamics occurring in the image dynamics. In this paper we propose a simplified model of dynamics of the helicopter and show that by placing some constraints in the choice of the position of the camera we can minimise the effect of the zero dynamics.
Minimum cost implementation of full VCR functionality in MPEG video streaming (2002)

With the proliferation of online multimedia content, the popularity of multimedia streaming technology, and the establishment of MPEG video coding standards, it is important to investigate how to efficiently implement an MPEG video streaming system. Digital video cassette recording (VCR) functionality enables quick and user friendly browsing of multimedia content, thus is highly desirable in streaming video applications. The implementation of full VCR functionality, however, presents several technical challenges which have not yet been well resolved. In this paper, we investigate the impact of the VCR functionality on the video decoder complexity and the network traffic. We also propose a minimum-cost scheme for the efficient implementation of MPEG streaming video system to provide full VCR functionality over a network with minimum requirements on the network bandwidth and the decoder complexity.
Chapter 6. Recent Developments in Nitroxide Mediated Polymerization (2015)

The current chapter highlights the latest developments in the fields of enhanced spin capturing polymerization (ESCP), in situ nitroxide mediated radical polymerization (in situ NMP) as well as nitroxide mediated photo-polymerization (NMP2), critically embedded into the latest developments in the wider field of reversible deactivation polymerization. Specific examples for each area are provided, noting the specific advantages and disadvantages of each technique, spanning the fields of block and star copolymer design to spatially resolved gradient surfaces.