gebhart/patrepeval huggingface dataset:
IMPACT OF DONOR-SPECIFIC ANTIBODIES ON CHRONIC REJECTION OCCURRENCE AND GRAFT LOSS IN RENAL TRANSPLANTATION: POSTTRANSPLANT ANALYSIS USING FLOW CYTOMETRIC TECHNIQUES1 (2001)

Flow cytometric techniques are precious tools for investigating the activation of the humoral response against HLA antigens of the graft in renal transplantation. DS-Abs production has a worse impact on organ function and survival than ARj episodes. These findings represent further proof of the threat posed by DS-Abs on long-term graft function and draw attention to the need for a specific immunosuppressive therapy aimed at counteracting the different kinds of immune activation toward graft.
Neonatal White Matter Abnormalities Predict Global Executive Function Impairment in Children Born Very Preterm (2011)

Using prospective longitudinal data from 110 very preterm and 113 full term children, this article describes the executive functioning abilities of very preterm children at age 4, and examines relations between the extent of white matter abnormality on neonatal magnetic resonance imaging (MRI) and later executive function outcomes. Very preterm children performed less well than full term children on measures of planning ability, cognitive flexibility, selective attention, and inhibitory control. Executive impairments at age 4 were confined to preterm children with mild or moderate-severe white matter abnormalities on MRI. Findings support the importance of cerebral white matter integrity for later executive function.
Seligi Depletion Management (1999)

Abstract The Seligi is a large oil field comprising a multi-closure anticlinal complex with the major reservoirs having relatively thin oil columns with large gas caps and aquifer of varying strength. The field contributes about one third of Esso Production Malaysia Inc.'s (EPMI) operated production and started to decline in 1995. A comprehensive depletion management study was initiated in 1997 to mitigate production decline and maximize ultimate recovery. This paper describes the challenges faced in managing this large resource, technologies used to address these challenges and some initial results from the studies. Early accomplishments include revised gas injection strategies, an inventory of wellbore opportunities, an optimized well / gathering system capacity, and infill / new development programs. Some of the above opportunities have been successfully implemented in the field; these have helped in mitigating production decline and increasing reserves capture.
SYNTHESIS OF LIPIDS BY CERTAIN YEAST STRAINS GROWN ON WHEY PERMEATE (1998)

ABSTRACT Four yeast strains, Apiotrichum curvatum ATCC 10567, Cryptococcus albidus ATCC 56297, Lipomyces starkeyi ATCC 12659, and Rhodosporidium toruloides ATCC 10788, were grown on whey permeate in order to synthesize lipid. Lipomyces starkeyii ATCC 12659 was identified as a high producer of lipid. It synthesized 36.9% lipids based on dry cell mass at a carbon:nitrogen ratio of 30:1 in shake‐flask experiments. The significant (p < 0.05) effect of both carbon:nitrogen ratio and yeast strain was observed on dry cell mass yield and lipid biosynthesis. All yeast strains except Rhodosporidium toruloides ATCC 10788 produced more triacylglycerols than phospholipids.
Non-Pharmacological Approaches for Migraine (2018)

Migraine is one of the most common and debilitating neurological disorders. However, the efficacy of pharmacological therapies may have unsatisfactory efficacy and can be poorly tolerated. There is a strong need in clinical practice for alternative approaches for both acute and preventive treatment. Occasionally, this need might arise in the context of low-frequency migraneurs who are not keen to use medication or fear the potential side effects. At the opposite end of the spectrum, clinicians might be faced with patients who have proven refractory to numerous medications. These patients may benefit from invasive treatment strategies. In recent years, promising strategies for migraine therapy have emerged alongside a progressively better understanding of the complex pathophysiology underlying this disease. This review discusses the most recent and evidence-based advances in non-pharmacological therapeutic approaches for migraine, offering alternatives to drug treatment for both the commonly encountered episodic cases as well as the more complex migraine phenotypes, which are capable of challenging even the headache specialist.
The Working Set Model for Program (1968)

an adequate model for program behavior. In this paper a new the model, is developed. The working of pages associated with a process, defined to be the collection of its most recently used pages, provides knowledge vital to the dynamic management of paged memories. Process and set are shown to be manifestations of the same ongoing computational activity; then processor demand and memory demand are defined; and resource allocation is formulated as the problem of balancing demands against available equipment.
Structural diversity in medicinal plants: Identification and quantitative analysis of secondary metabolites using HPTLC and LC-MS for determining its anti-inflammatory activity (2017)

One of the complex pathophysiological process i.e. inflammation (acute or chronic), which is mediated by a variety of signaling molecules. Lot of anti-inflammatory drugs (synthetic based origin) that are available but some of them are no longer use due to its side effects. Recently, people relied on various medicinal plant products especially leaves pertaining to secondary metabolites. In the present study, our group focused on various medicinal plants i.e. Prosopis spicigera, Anthocephalus cadamba, Mangifera indica and Madhuca indica in order to identified (qualitatively), isolated (quantitatively) and determined its secondary metabolites that are present in the aqueous leaves extract. The results of these studies showed that these secondary metabolites that are present in aqueous leaves extract showed wide variation in phytochemicals qualitatively and quantitatively using high performance thin layer chromatography (HPTLC) and also observed some variations in molecules identified through liquid chromatography mass spectrometry (LC-MS) as well. In addition, variable concentration of aqueous leaves extract of Prosopis spicigera, Anthocephalus cadamba, Mangifera indica and Madhuca indica when exposed to lysed human whole blood in presence of Concanavalin (Con)-A  and the results showed that aqueous leaves extract showed anti-inflammatory activity against Con A at higher doses.
The Analysis on Global Liquefied Natural Gas Supply and Demand Situation (2012)

This paper mainly introduces the global LNG supply and demand situation and trend of development, and predicts that the trading price of liquefied natural gas will subsequently be higher along with the higher demand in the future 10 years.
The involvement of taurine in the action mechanism of sodium valproate (VPA) in the treatment of epilepsy. (1993)

Several lines of evidence have shown that sodium valproate (VPA) mechanism of action in the therapy of epilepsy is based on the phenomena of its interaction with neurotransmitters (GABA), receptor sites and ion channels (1). However, there is no conclusive evidence to show the extent of VPA interactions with other neurotransmitters in the brain. Based on this fact, taurine (an amino acid 'neurotransmitter') found distributed in the brain the visual system may probably be involved in the drug action mechanism of VPA. The application of taurine in experimental and human epilepsy started over thirty years ago (2,3) and it has been known to possess some mild anticonvulsant activity in both humans and experimental animal models (4). This review, therefore, will attempt to draw together all the available information on the involvement of taurine in epilepsy and its possible association with the action mechanism of VPA in suppressing epileptic seizures. Structural and physiological distribution of taurine in the brain will be discussed. Its association with the phenomena of VPA action in epilepsy will be cited. Its neurotransmitter candidacy, involvement in ocular pathology, receptor sites and modulatory activity will be dealt with in relation to valproate action in the therapy of epilepsy.
Factors Associated with Blood Concentrations of Indoxyl Sulfate and <i>p</i>-Cresol in Patients Undergoing Peritoneal Dialysis (2010)

Background Accumulating evidence supports the important role of protein-bound uremic toxins such as indoxyl sulfate and p-cresol in uremic syndrome. They exert direct deleterious effects on a variety of cells and could link to clinical outcome. Factors relevant to indoxyl sulfate and p-cresol levels in peritoneal dialysis (PD) patients have rarely been investigated. We conducted a cross-sectional study to analyze the factors that correlate with both total and free indoxyl sulfate and p-cresol. Methods 182 stable PD patients with mean PD therapy duration 38.5 ± 33.3 months were enrolled. Their mean age was 48.9 ± 13.5 years; 62.6% (114/182) were female patients. Demographic data, including age, gender, and PD therapy duration, were reviewed and recorded. PD-associated features such as residual kidney function (RKF), peritoneal transport property, and dialysis modality were also recorded. Hemoglobin, blood urea nitrogen (BUN), serum creatinine, C-reactive protein, interleukin (IL)-6, and IL-10 were measured. Levels of total and free indoxyl sulfate and p-cresol were determined. Results Patients without RKF had lower Kt/V and weekly creatinine clearance and higher serum creatinine and IL-6 levels. These patients also had higher total and free indoxyl sulfate levels. There was no difference in indoxyl sulfate or p-cresol levels compared to patients with different peritoneal transport properties or with different treatment modalities. Multivariate regression analysis revealed that weekly creatinine clearance and serum creatinine were independent associates of total indoxyl sulfate level; IL-6, total indoxyl sulfate, and free p-cresol were associated with free indoxyl sulfate level. Weekly creatinine clearance and free p-cresol level independently correlated with total p-cresol; while gender, total p-cresol, and free indoxyl sulfate were associated with free p-cresol level. Conclusion The free forms of indoxyl sulfate and p-cresol constituted a small portion of their total forms. The presence of RKF affected levels of free and total indoxyl sulfate. IL-6 level was significantly associated with free indoxyl sulfate level. There was a close relationship between indoxyl sulfate and p-cresol levels in their free forms in PD patients.
Automatic generation of ground truth for the evaluation of obstacle detection and tracking techniques (2018)

As automated vehicles are getting closer to becoming a reality, it will become mandatory to be able to characterise the performance of their obstacle detection systems. This validation process requires large amounts of ground-truth data, which is currently generated by manually annotation. In this paper, we propose a novel methodology to generate ground-truth kinematics datasets for specific objects in real-world scenes. Our procedure requires no annotation whatsoever, human intervention being limited to sensors calibration. We present the recording platform which was exploited to acquire the reference data and a detailed and thorough analytical study of the propagation of errors in our procedure. This allows us to provide detailed precision metrics for each and every data item in our datasets. Finally some visualisations of the acquired data are given.
On the Wiring of Two-Dimensional Multiple-Coincidence Magnetic Memories (1956)

The application of Minnick and Ashenhurst's technique of p-fold multiple-coincidence magnetic storage in an n x n array of cores is shown to require finding (p-2) orthogonal Latin squares of order n. The value of this technique lies in the reduction it effects in the disturbance of unselected cores. A method is suggested for reducing this disturbance to a level lower than that obtained by Minnick and Ashenhurst, by the application of reverse currents to the unselected interrogating wires during interrogation. The disturbance of unselected cores can be reduced to zero if p=n+1. In this case, (n+1) cores can be added to the store at the expense of a single additional interrogating wire. The resulting array of cores and interrogating wires is closely related to the finite projective geometry of order n.
Spectra of graphs with circulant blocks and their applications (2002)

A class of graphs with circulant blocks, i.e. graphs which can be decomposed into circulant subgraphs, is considered. A closed form formula for eigenvalues of the decomposed graph in terms of eigenvalues of partition subgraphs is given. Decomposition into two layer graph is distinguished as the most computationally effective case. A formula for counting spanning trees in graphs with circulant blocks, based on eigenvalues, is introduced. Illustrative examples test the method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Constructing Storage Capacity Migration Policies for Information Lifecycle Management System (2010)

To maintain very large amount of increasing dataset, it is critical to enforce the data migration policies across different levels of storage devices. The challenge is to achieve both low storage cost and response efficiency. In this paper, we will investigate the factors for this problem, then adapt dynamic programming technique, and design appropriate ECA trigger rules. From the conducted experiments, our methodology provides a feasible solution for this important kernel issue of the Information Lifecycle Management (ILM) problem.
Infinite electrical networks with finite sources at infinity (1987)

Various physical situations leading to the exterior problem for partial differential equations are modeled by infinite electrical networks having finite-valued sources connected to extremities of the network at infinity. Up to now, there was no theory for such a network. The present work establishes one. An existence and uniqueness theorem is proven for a countably infinite resistive network that has an infinity of voltage and current sources, some of which connect to different "parts of infinity," as well as certain finite and infinite nodes that are shorted to different "parts of infinity" as well. The phrase in quotes is made precise by introducing the new concepts of extended nodes, extended branches, pathlike extremities, and extremities for the network. Moreover, short circuits between different pathlike extremities are allowed. The hypothesis of the theorem requires that the maximum power available from all the sources in the network be finite. Some examples are given, relating to petroleum flow in an oil well and to well-logging for geophysical exploration, to show how the considered infinite electrical networks can arise from practical applications.
X‐ray source and the output factor (1995)

When the collimator setting of a linear accelerator is made sufficiently small, the output factor in air, R, is greatly reduced because the collimators obstruct the periphery of the x-ray source. This has been utilized to examine the size of the source by varying the width y of a narrow field and determining how R(y) varies. The sources diameters in the two principal directions were clearly influenced by the design of the accelerators. The x-ray sources of two accelerators with bending magnets were found to be noncircular while that of a linear accelerator without a magnet showed circular symmetry. The position of the source relative to the axis of collimator rotation was determined by measuring R for offset narrow fields. For one of the accelerators, the source was initially moving and off the central axis by about 2 mm for the first five monitor units. The results correlated well with sharpness in portal-film images. The technique can serve to evaluate the major source characteristics in acceptance testing and quality control.
Implementing a Collaboration Platform : Making Behavior Change Part of the Plan (2011)

For two global programs a rural sanitation project and a hand-washing project with the goals of scaling up access to sanitation and increasing hygiene behaviors how can lessons be shared easily and efficiently with a global team across six countries, including headquarters-based staff? That is what the Water and Sanitation Program (WSP) sought to do in 2008 by creating a virtual collaborative workspace, www.learningtoscaleup.org. This smart lesson documents the challenges of trying to create a cultural shift from communicating primarily via e-mail and phone calls to using a virtual platform. Although the platform is no longer used, the lessons learned from the experience might help inform other teams seeking to create a platform.
Evidence for the Modulation of Sexual Behavior by α-Adrenoceptors in Male Rats (1985)

Clonidine, a commonly used antihypertensive agent believed to act by stimulation of central alpha-adrenoceptors, produced a dose-related suppression of ejaculatory behavior in sexually vigorous male rats throughout the range of treatment (0.0125-0.5 mg/kg). Treatment with 0.25 mg/kg virtually eliminated ejaculatory behavior, without altering the number of animals mounting and intromitting. These effects were maintained for at least 4 h after treatment. Prazosin, another antihypertensive (but acting by blockade of alpha 1-adrenoceptors), increased latencies to initiation of copulation, to ejaculation, and to reinstatement of copulation following ejaculation. Additionally, prazosin (1 mg/kg) pretreatment failed to attenuate or prevent the clonidine-induced suppression of ejaculation. In contrast, yohimbine, a drug which preferentially blocks alpha 2-adrenoceptors (2 mg/kg, 20 min prior to mating tests), caused a facilitation of copulatory behavior as evidenced by drastic decreases in ejaculation latency and intercopulatory and postejaculatory intervals. Pretreatment with yohimbine completely prevented the clonidine-induced suppression of ejaculation, while clonidine attenuated the facilitatory effects of yohimbine, suggesting a competitive interaction. These data lead to the suggestion that increased excitatory adrenergic activity results in increased sexual arousal either by blockade of alpha 2-or stimulation of alpha 1-adrenoceptors. Alternatively, stimulation of alpha 2-or blockade of alpha 1-adrenoceptors results in diminished sexual motivation. While the precise implications of this animal research for the clinic are as yet unclear, further research could lead to important developments in the pharmacological treatment of sexual dysfunctions.
Design and Inmplementation of RTE Generator for Automotive Embedded Software (2009)

Runtime environment is located in a middle layer of the AUTOSAR architecture to provide infrastructure services that enable not only the communication between software components, but also between software components and basic software components. An RTE generator is an automated generation tool for the AUTOSAR specification based RTE according to the ECU configuration. It generates a communication API function for software components and basic software components like OS and COM of the application. The availability and accuracy of the RTE generator are important for the automobile software which is based on the AUTOSAR architecture. This paper proposes an architectural design of an RTE generator for the auto-generation of the AUTOSAR based RTE. Then an RTE code generator is implemented based on the proposed architecture to generate RTE code for a simple AUTOSAR application. The generated RTE code shows that the designed and implemented RTE generator correctly reflects the configuration of the test application.
Approximating the centroid is hard (2007)

Consider the problem of computing the centroid of a convex body in n-dimensional Euclidean space. We prove that if the body is a polytope given as an intersection of half-spaces, then computing the centroid exactly is #P-hard, even for order polytopes, a special case of 0-1 polytopes. We also prove that if the body is given by a membership oracle, then for any deterministic algorithm that makes a polynomial number of queries there exists a body satisfying a roundedness condition such that the output of the algorithm is outside a ball of radius sigma/100 around the centroid, where sigma^2 is the minimum eigenvalue of the inertia matrix of the body.
Power plane resonances as a source of delta-I noise and the influence of decoupling capacitors (2002)

This contribution presents a study of the influence of power planes resonances on the delta-I noise. Noise generated at one point in a system can be transported to a distant point. This phenomenon is studied using the FDTD-technique and a transfer impedance is introduced to quantify the results. To shield sensitive ICs, capacitive decoupling can be used. The influence of such capacitive shielding is discussed. Analytical approximations are given together with more details on the influence of the different parameters.
Stress-free aging of optical fibers in liquid water and humid environments: part 1 (1992)

The strength degradation of three commercially available telecommunications fibers was evaluated after stress-free aging in 85°C liquid water, 85°C at 94% r.h., 85°C at 85% r.h., and 85°C at 60% r.h. Interim results show that the three fibers show different aging resistances, depending on the environment. Strength loss of up to 50% after 45 days in 85°C water was observed. Atomic Force Microscopy was used to image the cladding surface, and estimate the strength determining flaw size. The data show qualitative correlation between strength loss and flaw size. While the mechanisms underlying stress-free crack growth are not well understood, strength degradation must be predicted, nonetheless, in order to ensure acceptable reliability for fiber-based systems in the outside plant.
Optimizing Consistent Merging and Pruning of Subgraphs in Network Tomography (2019)

A communication network can be modeled as a directed connected graph with edge weights that characterize performance metrics such as loss and delay. Network tomography aims to infer these edge weights from their pathwise versions measured on a set of intersecting paths between a subset of boundary vertices, and even the underlying graph when this is not known. Recent work has established conditions under which the underlying directed graph can be recovered exactly the pairwise Path Correlation Data, namely, the set of weights of intersection of each pair of directed paths to and from each endpoint. Algorithmically, this enables us to consistently fused tree-based view of the set of network paths to and from each endpoint to reconstruct the underlying network. However, in practice the PCD is not consistently determined by path measurements. Statistical fluctuations give rise to inconsistent inferred weight of edges from measurement based on different endpoints, as do operational constraints on synchronization, and deviations from the underlying packet transmission model. Furthermore, ad hoc solutions to eliminate noise, such as pruning small weight inferred links, are hard to apply in a consistent manner that preserves known end-to-end metric values. This paper takes a unified approach to the problem of inconsistent weight estimation. We formulate two type of inconsistency: \textsl{intrinsic}, when the weight set is internally inconsistent, and \textsl{extrinsic}, when they are inconsistent with a set of known end-to-end path metrics. In both cases we map inconsistent weight to consistent PCD within a least-squares framework. We evaluate the performance of this mapping in composition with tree-based inference algorithms.