gebhart/patrepeval huggingface dataset:
The effect of channel dimensions on the millimeter-wave power performance of a pseudomorphic HEMT (2002)

The authors study the effect of channel dimensions on the millimeter-wave power performance of a double-recessed pseudomorphic high electron mobility transistor (PHEMT). The choice of channel recess dimension, specifically the gate to drain n+ ledge separation (Lgd), seemed to have the most pronounced effect on transistor's power performance. Gate-drain capacitance, output conductance, drain delay (unity current gain frequency) and reverse breakdown voltage were all strong functions of Lgd. With this parameter optimized, a PHEMT exhibited the best power performance yet reported at Ka-band and state-of-the-art performance at Q-band. A Q-band MMIC power amplifier using an existing design was also realized. The two-stage amplifier exhibited 500 mW of ouput power with 7 dB gain and 15% PAE at 40 GHz. This result is the best published performance for a MMIC at this frequency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Capture of platelets to the endothelium of the femoral vein is mediated by CD62P and CD162 (2009)

Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is known about the mechanisms of inflammation in large veins and the role of platelets in inflamed large veins. For this purpose, we investigated primary and secondary interactions between platelets, leukocytes and endothelial cells in the femoral vein in vivo with special regard to the role of CD62P (P-selectin) and CD162 (PSGL-1). Mice were challenged with lipopolysaccharide (LPS)/D-galactosamine (D-gal) and either CD162 or CD62P was blocked by intravenous administration of a corresponding antibody at the time point of LPS/D-gal injection. Four hours after LPS/gal injection, intravital fluorescence microscopy of the femoral vein was performed and primary and secondary platelet-leukocyte-endothelial cell-interactions were visualized after in vivo platelet and leukocyte staining with rhodamine 6G. Analysis of intravital fluorescence microscopy revealed that LPS/D-gal caused a strong inflammatory reaction of the venous endothelium with significant induction of platelet and leukocyte tethering, rolling and adhesion. Secondary interactions of platelets to adherent or rolling platelets or leukocytes were also increased after LPS/D-gal-injection. Immunoneutralization of either CD162 or CD62P significantly decreased platelet primary and secondary capture as well as leukocyte rolling and adhesion. CD162 and CD62P play a central role in mediating inflammatory primary and secondary interactions of platelets and leukocytes to the endothelium in inflamed large veins in vivo. Thus, blocking CD162 or CD62P might be an attractive tool for preventing platelet and leukocyte-driven venous diseases.
66‐1: <i>Invited Paper:</i> Fast‐response IPS‐LCDs used in VR applications (2019)

We discuss the moving picture characteristics of display devices required for virtual reality head‐mounted displays (VR‐HMDs). We propose a fast response in‐plane switching (IPS) liquid crystal display (LCD) mode, called the short‐range lurch control IPS (SLC‐IPS) LCD mode, for VR‐HMDs based on experimental results of its response properties.
Epoxide Opening-Induced Tandem 8-Azabicyclo[3.2.1]octane to 6-Azabicyclo[3.2.1]octane Rearrangement−Iminium Allylation: Synthesis of (±)-Peduncularine (2010)

An efficient Lewis acid induced nitrogen-driven rearrangement iminium-trapping cascade from an epoxytropinone 3 gives a 7-allylated 6-azabicyclo[3.2.1]octan-3-one 2, which is converted into the alkaloid (+/-)-peduncularine (1).
Effect of gravity on halogenated hydrocarbon flame retardant effectiveness (1984)

Flammability limits, burning velocities, and minimum ignition energies under initially quiescent conditions were measured for stoichiometric and fuel-lean methane-, ethane-, and propane-air mixtures containing varying concentrations of Halon 1301. The characteristics of near-limit flames were strongly affected by fuel type but not Halon concentration. The conclusions were that the mechanism of the flammability limits was affected by fuel type but not Halon concentration, that the zero-g flammability limit is probably related to a stability criterion which is affected mostly by the molecular diffusion characteristics of the reactant gases and is mostly independent of chemical kinetics, and that the one-g upward flammability and ignition limits provide adequate criteria for safety at one-g and zero-g for both uninhibited and inhibited mixtures.
Modafinil for cocaine addiction: Multi-site clinical trial (2008)

Salivary gland epithelial neoplasms are rare in children and adolescents, with only a handful of large series having been published. A retrospective study was conducted for 57 cases in patients 20 years or younger. The tumors were located in the parotid (n = 36), submandibular gland (n = 7), and minor salivary glands (n = 14). Nineteen (33%) tumors were pleomorphic adenoma, whereas the remaining (67%) were malignant. The histologic types of carcinomas were mucoepidermoid carcinoma (MEC, n = 19, 33%), acinic cell carcinoma (n = 7, 12%), adenoid cystic carcinoma (n = 6, 11%), secretory carcinoma (mammary analogue) (SC, n = 4, 7%), and myoepithelial carcinoma (n = 2, 4%). Ninety-three percent (13/14) of the minor and 58% (25/43) of the major salivary gland tumors were malignant. A 7-year-old girl (2%) with a high-grade MEC died from her disease because of uncontrollable locoregional recurrence. Seven patients (16%) developed recurrence including 2 distant metastases from adenoid cystic carcinoma and 6 locoregional recurrences (2 pleomorphic adenomas, 1 SC, 1 myoepithelial carcinoma, 1 adenoid cystic carcinoma, and 1 MEC). The following parameters were associated with decreased disease-free survival in malignant tumors: elevated mitotic index of >4/10 high-power fields (log-rank test, P < .001), and advanced American Joint Committee on Cancer pT (P = .029) and pN stage (P < .001). In conclusion, myoepithelial carcinoma and SC can occur in the pediatric population and should be considered in the differential diagnosis. Salivary gland malignancies in children appear to have better clinical outcome, associated with a 10-year recurrence-free survival rate of 74% and a 10-year disease-specific survival of 94%.
Steady-state levels of G-protein beta-subunit expression are regulated by treatment of cells with bacterial toxins (1987)

Cultures of 3T3-L1 cells were incubated with either 10 ng/ml cholera toxin or 10 ng/ml pertussis toxin from 4 days prior to the initiation of differentiation and throughout the subsequent incubation. Toxin concentrations were sufficient to completely prevent the labelling of alpha-subunits with (/sup 32/P)NAD/sup +/ and pertussis toxin and to prevent by more than 90% the labelling with (/sup 32/P)NAD/sup +/ and cholera toxin in membranes prepared from these cells. Neither toxin prevented the differentiation to the adipocyte phenotype. Neither toxin prevented the increases in the relative amounts of G-proteins which occur upon differentiation. Both toxins dramatically decreased the amount of beta-subunits. As measured by quantitative immunoblotting with antisera specific for both the 35 kDa and 36 kDa beta-subunits, levels of beta-subunit were decreased by more than 50% of steady-state level of control cells. Thus, bacterial toxins which modifies G-protein alpha-subunits are capable of modulating the levels of beta-subunits in vivo. The basis for the regulation of G-protein subunit expression by bacterial toxins is under study.
Aligned chitosan-based nanofibers for enhanced myogenesis (2010)

Tissue-engineered nanofibrous matrices can potentially serve as an implantable scaffold for the reconstruction of damaged or lost tissue by regulating cell proliferation, organization, and function. In this study, we developed a polyblend chitosan-polycaprolactone (PCL) nanofibrous scaffold with unidirectional fiber orientation by electrospinning for skeletal muscle tissue reconstruction and investigated the effect of the fiber alignment on cell organization and differentiation in comparison with randomly oriented nanofibers and 2D films of the same material. The chitosan-PCL material was shown to support skeletal muscle cell attachment and proliferation, and the fiber alignment promoted skeletal muscle cell morphogenesis and aligned myotube formation in the nanofiber orientation. Reverse-transcription PCR analyses revealed an up-regulation of differentiation-specific genes, troponin T and myosin heavy chain, in muscle cells on the aligned nanofiber scaffolds, confirming the ability of aligned chitosan-PCL nanofibers to enhance muscle cell differentiation. These results suggest that chitosan-PCL nanofibrous scaffolds with unidirectional fiber orientation can significantly enhanced muscle cell development making it a potential scaffold for enhanced skeletal myogenesis.
Recovery of <i>Lactobacillus bulgaricus</i> and <i>Streptococcus thermophilus</i> on Nine Commonly Used Agar Media (1974)

Of the nine media tested, Eugon, Elliker's lactic agar, pH 6.8, and modified tryptic soy broth agars showed superior recovery of Lactobacillus bulgaricus and Streptococcus thermophilus strains.
Addressing problems faced by 'commuter' students in higher education (2016)

The importance of a smooth transition from secondary into higher education has been noted in the literature with a focus on the need for\nstudents to integrate, develop a social and academic identity and acquire appropriate independent learning skills. However, much of the work\nhas not taken account of the increasingly diverse student body where many do not leave home but commute on a daily basis whilst retaining parttime\njobs, making recommended transition models difficult to implement.\nThis study aims to deepen our understanding and address issues faced by commuter students: why they live at home; what issues this raises\nfor their studies and how we might be able to develop approaches which make their transition easier. The study will be carried out in the Faculty\nof Business and Law at a UK University in the South East where a survey completed in 2014-2015 amongst first year students found that only\n24% (n=446) were living in halls of residence, with 55% living at home. 33% had part-time jobs with 87% of these working more than 9 hours per\nweek.\nThree questions will guide the research: 1. Why do students become “commuter students”? 2. What are the specific problems faced by\ncommuter students during the first year at University? 3. What are the possible ways we could help commuter students in the first year at\nUniversity? The study will begin with a literature review on the commuter student. Several studies have already started to address this issue (e.g.,\nHoldsworth, 2006; Meuleman et al., 2015; Trowler, 2015) often within the “transitions” literature.\nThe second phase will take a qualitative approach, using in-depth interviews with ten first year Business students. Data analysis will begin with\nopen coding, then axial coding and finally selective coding and we will report our findings around the selected themes, using anonymous\nquotations to illustrate key points.\nReferences\nHoldsworth, C. (2006) 'Don't you think you're missing out, living at home? Student experiences and residential transitions', The Sociological\nReview, 54(3), pp.495-519.\nMeuleman, A-M., Garrett, R., Wrench, A. and King, S. (2015) ‘Some people might say I'm thriving but… : ’non-traditional students' experiences of\nuniversity, International Journal of Inclusive Education, 19(5), pp. 503-517.\nTrowler, V. (2015) ‘Negotiating Contestations and ‘Chaotic Conceptions’: Engaging ‘Non-Traditional’ Students in Higher Education’ Higher\nEducation Quarterly, 69(3), pp. 295–310
INJECTION MOLDED 97W-2Ni-1Fe HEAVY ALLOY (1999)

97W-2Ni-1Fe heavy alloy feedstocks with different powder loadings were prepared forinjection molding. The rheological behavior of these feedstocks was studied. The mechanical properties ofas-sintered parts and the shrinkage during sintering were measured. The results showed that the rheologicalbehavior of these feedstocks could be described as pseudoplastic fluid. The mechanical properties of theINjection molded alloy were superior to those of alloy prepared by conventional press/sinter process. Thereis an optimal powder loading of 47(volume fraction,%) with the best mechanical properties. The shrinkageduring sintering was isotropical and the tolerances of products were small.
Correlation of the suicide phenomenon in Aeromonas species with virulence and enteropathogenicity (1988)

Certain strains of mesophilic aeromonads (Aeromonas hydrophila, A. sorbria, and A. caviae), when grown in broth containing 0.5% glucose, undergo growth inhibition concomitant with acetate accumulation. Because these strains are nonviable after 24 h, this phenomenon is termed suicide. We investigated suicidal strains of Aeromonas species as a means of understanding animal virulence and enteropathogenicity. To assess virulence, batches of five white mice were inoculated intraperitoneally with 10(7) cells (washed) of suicidal and nonsuicidal strains of A. hydrophila and A. sobria and suicidal strains of A. caviae. The three nonsuicidal strains of A. sobria tested showed lethality as early as 12 h and were uniformly fatal within 36 h postinoculation. After 36 h, the three suicidal strains killed only 1 of 15 mice inoculated. Four A. hydrophila strains tested which showed the suicide phenomenon at 37 degrees C were variably lethal (40 to 100%). None of three suicidal strains of A. caviae were lethal. Enteropathogenicity was studied by orally inoculating three white mice each with the same Aeromonas strains (10(8) cells, in skim milk) and assessing diarrhea and intestinal fluid accumulation. Diarrhea and fluid accumulation were present in all mice inoculated with two nonsuicidal strains of A. sobria and in 4 of 12 mice given four suicidal strains of A. hydrophila. Two suicidal strains each of A. sorbria and A. caviae failed to elicit any gastrointestinal disturbances. These data suggest that the suicide phenomenon may explain strain-specific (A. sobria and A. hydrophila) and species-specific (A. caviae) virulence and enteropathogenicity.
Flexible Web-Based Educational System for Teaching Computer Architecture and Organization (2005)

An important problem in teaching courses in computer architecture and organization is to find a way to help students to make a cognitive leap from the blackboard description of a computer system to its utilization as a programmable device. Computer simulators developed to tackle this problem vary in scope, target architecture, user interface, and support for distance learning. Usually, they include the processor only, lacking the whole-system perspective. The existing simulators mainly focus on the programmer's view of the machine and do not provide the designer's perspective. This paper presents an educational computer system and its Web-based simulator, designed to help teaching and learning computer architecture and organization courses. The educational computer system is designed to cover a broad spectrum of topics taught in lower division courses. It offers a unique environment that exposes students to both the programmer and the designer's perspective of the computer system. The Web-based simulator features an interactive animation of program execution and allows students to navigate through different levels of the educational computer system's hierarchy-starting from the top level with block representation down to the implementation level with standard sequential and combinational logic blocks.
Clicking on trans-translation drug targets (2015)

OPINION article Front. Microbiol., 19 May 2015Sec. Microbial Physiology and Metabolism https://doi.org/10.3389/fmicb.2015.00498
Localized states and self-similar states of electrons on a two-dimensional Penrose lattice (1988)

Eigenstates with an energy E=2 are analyzed for a tight-binding Schr\"odinger equation -${\mathcal{J}}_{〈j}$,i〉${\mathrm{\ensuremath{\psi}}}_{\mathrm{j}}$=E${\mathrm{\ensuremath{\psi}}}_{\mathrm{i}}$ on a two-dimensional Penrose lattice. Two different kinds of eigenstates exist. One is strictly localized and the other is on certain strings of rhombuses with one three-edge vertex plus some additions. The latter tends to states whose support is self-similar and fractal with a dimension ln2/ln\ensuremath{\tau} on an infinite lattice. The fraction of eigenstates in the spectrum with E=2 is obtained exactly and is 6.8189%.
Imprinting of slip bands in mechanically deformed MgO crystals using lithium impurities (1980)

Abstract Lithium impurities in MgO can be used to imprint slip bands produced by plastic deformation. The imprinting is obtained by means of [Li] defects (sub-titutional Li+ ions each with an adjacent O−ion) which absorb light at 680 nm (1·8 eV). Slip bands are observed as discoloured regions against the background of dark blue coloration due to these defects. The decoloration can be achieved by two different processes : either by oxidation at 1275 K of a deformed crystal, or by the reverse procedure—deformation of a previously oxidized crystal. The mechanisms involved in the decoloration are different; the former is due to ionic motion, and the latter is an electronic effect. Similar procedures involving surface indentation by sharp objects also result in decoloration patterns.
Measurement of intrahepatic pressure as an index of hepatic sinusoidal pressure. (1987)

Intrahepatic pressure was measured in 148 patients with liver disease (32 outpatients, 116 inpatients) and 13 controls with almost normal liver histology (inpatients), with a 23-gauge needle (inner diameter 0.38 mm). Intrahepatic pressure was significantly elevated in the group order of chronic active hepatitis without bridging necrosis (n = 17, 9.2 +/- 3.0 mm Hg), chronic active hepatitis with bridging necrosis (n = 24, 12.3 +/- 5.7), and posthepatitic liver cirrhosis (n = 65, 18.8 +/- 4.2), compared with controls (n = 13, 6.8 +/- 2.7), whereas it was not elevated in the group of idiopathic portal hypertension (n = 9, 7.8 +/- 2.5 mm Hg), acute hepatitis (n = 10, 8.4 +/- 2.6 mm Hg), and chronic persistent hepatitis (n = 23, 7.9 +/- 2.7 mm Hg), compared with controls. As complications, four patients had abdominal discomfort continuing for more than a day; however, patients were allowed to walk after they had rested on their beds for 30 min. In 37 patients (27 with cirrhosis, seven idiopathic portal hypertension, and three others), portal vein and/or hepatic vein catheterization was performed during the same procedure of intrahepatic pressure measurement. Intrahepatic pressure showed significant correlations with corrected wedged hepatic vein pressure (r = 0.91), portohepatic gradient (r = 0.69), wedged hepatic vein pressure (r = 0.79), and portal vein pressure (r = 0.68). Slopes were 0.97, 0.83, 0.66, and 0.65, respectively. In conclusion, intrahepatic pressure reflects hepatic sinusoidal pressure (corrected wedged hepatic vein pressure), and intrahepatic pressure starts to elevate at the stage of chronic active hepatitis.
Stability analysis for discrete time switched systems with temporary uncertain switching signal (2007)

This paper is dedicated to the stability analysis of switched systems with uncertain switching signal. We consider the case of discrete time switched systems that are stabilized by a switched state feedback for which the switching signal may be temporary uncertain. Dwell time conditions for stability analysis of such systems are given. The approach is applied to the case of switched systems with time-varying delay in the input and to continuous time switched systems in digital control loops with inter-sample switching.
Ultra-long range correlations of the dynamics of jammed soft matter (2010)

We use Photon Correlation Imaging, a recently introduced space-resolved dynamic light scattering method, to investigate the spatial correlation of the dynamics of a variety of jammed and glassy soft materials. Strikingly, we find that in deeply jammed soft materials spatial correlations of the dynamics are quite generally ultra-long ranged, extending up to the system size, orders of magnitude larger than any relevant structural length scale, such as the particle size, or the mesh size for colloidal gel systems. This has to be contrasted with the case of molecular, colloidal and granular ``supercooled'' fluids, where spatial correlations of the dynamics extend over a few particles at most. Our findings suggest that ultra long range spatial correlations in the dynamics of a system are directly related to the origin of elasticity. While solid-like systems with entropic elasticity exhibit very moderate correlations, systems with enthalpic elasticity exhibit ultra-long range correlations due to the effective transmission of strains throughout the contact network.
Carrier Synthesis from Perturbed DSB/SC Signals (1967)

International Telemetering Conference Proceedings / October 02-04, 1967 / Marriott Motor Hotel, Washington, D.C.
<i>Retracted:</i> Transactivation of <i>CCL20</i> gene by Epstein–Barr virus latent membrane protein 1 (2005)

CCL20 is expected to play a crucial role in the initiation of immune responses and tumour growth. However, expression of CCL20 in Epstein-Barr virus (EBV)-associated diseases has not been studied. We examined the contribution of EBV infection and EBV-encoded latent membrane protein (LMP)-1 to CCL20 expression. EBV infection and LMP-1 induced CCL20 mRNA expression in the EBV-negative Burkitt lymphoma (BL) cell lines and the embryonic kidney cell line. Histone deacetylase inhibitor-stimulated endogenous LMP-1 also induced CCL20 expression in an EBV-positive BL cell line. Analysis of the CCL20 promoter showed that it was activated by LMP-1 C-terminal activation region (CTAR)-1 and CTAR-2. Co-expression of IkappaB alpha, IkappaB beta, IkappaB kinase (IKK)alpha, IKKbeta, IKKgamma, nuclear factor (NF)-kappaB-inducing kinase and tumour necrosis factor receptor-associated factor 2 dominant-negative constructs with LMP-1 inhibited the activation of the CCL20 promoter by LMP-1, suggesting that LMP-1 induces CCL20 via NF-kappaB signalling. The requirement for the NF-kappaB-binding site in the CCL20 promoter in LMP-1 responsiveness was established. Our results indicate that activation of the NF-kappaB pathway by LMP-1 is required for the activation of CCL20 expression.
The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase (2006)

The c-Fes protein tyrosine kinase is implicated in the differentiation of a number of cell types including neuronal, endothelial and myeloid cells. Structurally, Fes consists of a unique N-terminal region, followed by SH2 (Src homology domain 2) and kinase domains. Two coiled-coil (CC) domains (CC1 and CC2) located within the unique N-terminal region are critical regulators of Fes activity in vivo and may function to recruit Fes activators and/or substrates. A yeast two-hybrid screen, utilizing a K-562 cell cDNA library and the Fes CC2 domain as bait, identified an interacting clone encoding the CC domain and B-box motifs (residues 114-357) of the transcriptional co-repressor KRAB-associated protein (KAP)-1. KAP-1(114-357) interacted with full-length Fes in yeast, and the KAP-1 CC domain was sufficient to bind the Fes N-terminal region in Sf-9 cells. Co-expression of Fes with full-length KAP-1 in human 293T cells stimulated Fes autophosphorylation and led to KAP-1 tyrosine phosphorylation. Association of endogenous Fes and KAP-1 was also observed in HL-60 myeloid leukaemia cells. Together, these data identify a novel Fes-KAP-1 interaction, and suggest a dual role for KAP-1 as both a Fes activator and downstream effector.