gebhart/patrepeval huggingface dataset:
Minireview Should Replace the SCN as the In Vitro Model of Choice (1998)

circadian rhythms are less easy todismiss, as they occur within neuronal as well as non-Everyonceina while there appearsa setof experiments neuronal cell types (Liu et al., 1988; Siwicki et al., 1988).that changes theway a field views itself. Thisiscertainly Moreover, tight molecular connections between fruit flythecasewiththeBalsalobreetal.(1998)paperpublished and mammalian rhythms now exist, thanks in large partin this issue of
Spherical Torus Plasma Interactions with Large-area Liquid Lithium Surfaces in CDX-U (2002)

The Current Drive Experiment-Upgrade (CDX-U) device at the Princeton Plasma Physics Laboratory (PPPL) is a spherical torus (ST) dedicated to the exploration of liquid lithium as a potential solution to reactor first-wall problems such as heat load and erosion, neutron damage and activation, and tritium inventory and breeding. Initial lithium limiter experiments were conducted with a toroidally-local liquid lithium rail limiter (L3) from the University of California at San Diego. Spectroscopic measurements showed a clear reduction of impurities in plasmas with the L3, compared to discharges with a boron carbide limiter. The evidence for a reduction in recycling was less apparent, however. This may be attributable to the relatively small area in contact with the plasma, and the presence of high-recycling surfaces elsewhere in the vacuum chamber. This conclusion was tested in subsequent experiments with a fully toroidal lithium limiter that was installed above the floor of the vacuum vessel. The new limiter covered over ten times the area of the L3 facing the plasma. Experiments with the toroidal lithium limiter have recently begun. This paper describes the conditioning required to prepare the lithium surface for plasma operations, and effect of the toroidal liquid lithium limiter on discharge performance.
Transformations of cephalosporanates: the formation of 4-alkoxyformamidoceph-2- and -3-ems (1979)

A ceph-3-emcarboxylic acid reacted with diphenylphosphoryl azide–toluene–t-butyl alcohol–triethylamine to give the 4α- and 4β-t-butoxycarbonylceph-2-ems and a 4-t-butoxyformamidoceph-2-em. Interconversion studies on the 4α- and 4β-esters were performed. Reaction in the presence of excess of sodium azide gave as the sole β-lactam product a 4-t-butoxyformamidoceph-3-em.
An Ultraviolet Spectrophotometric Method for the Determination of Benzene Hexachloride (1949)

Journal Article An Ultraviolet Spectrophotometric Method for the Determination of Benzene Hexachloride Get access Bernard Davidow, Bernard Davidow Search for other works by this author on: Oxford Academic Google Scholar Geoffrey Woodard Geoffrey Woodard Division of Pharmacology, Food and Drug Administration, Federal Security Agency, Washington 25, D.C Search for other works by this author on: Oxford Academic Google Scholar Journal of Association of Official Agricultural Chemists, Volume 32, Issue 4, 1 November 1949, Pages 751–757, https://doi.org/10.1093/jaoac/32.4.751 Published: 11 February 2020
Speeding up the Training of Lattice-Ladder Multilayer Perceptrons (2002)

A lattice-ladder multilayer perceptron (LLMLP) is an appealing structure for advanced signal processing in a sense that it is nonlinear, possesses infinite impulse response and stability monitoring of it during training is simple. However, even moderate implementation of LLMLP training hinders the fact that a lot of storage and computation power must be allocated. In this paper we deal with the problem of computational efficiency of LLMLP training algorithms that are based on computation of gradients, e.g., backpropagation, conjugate-gradient or Levenberg-Marquardt.The paper aims to explore most computationally demanding calculations---computation of gradients for lattice (rotation)parameters. Here we find and propose to use for training of several LLMLP architectures a simplest in terms of storage and number of delay elements computation of exact gradients, assuming that the coefficients of the lattice-ladder filter are held stationary.
Serum Amyloid P Component (SAP)‐Like Protein From Botryllid Ascidians Provides a Clue to Amyloid Function (1992)

The HA-1 lectin isolated from Botrylloides leachii has an amino acid composition similar to that of mammalian serum amyloid protein (SAP). SAP is a universal component of mammalian amyloid deposits. Like SAP, HA-1 has a disc ultrastructure, and antibody to HA-1 binds both (a) to amyloidlike fibers deposited between rejected Botrylloides colonies and (b) to cerebral amyloid deposits in Alzheimer's disease brains. Deposition of protochordate amyloid within rejection sites and surrounding fouling organisms implies that these fibers function as barriers to allogeneic and infectious challenge. Similarly, mammalian amyloid may also function to contain inflammatory lesions and to limit the spread of certain infections. Pathological amyloidotic conditions in humans, such as Alzheimer's disease, may result from unregulated expression of this primitive encapsulation response.
Mechanisms of Cell Adhesion in the Nervous System: Role of the Immunoglobulin Gene Superfamily (1989)

The amino acid sequences of a large number of the cell surface proteins known to mediate cell-cell interactions in the nervous system have recently been reported. Many of these proteins are members of the immunoglobulin gene superfamily and have remarkably similar structures and amino acid sequences in their extracellular segments. We have termed this family of immunoglobulin-related cell adhesion molecules the Ig-CAMs. In this article, we review the structural features of the Ig-CAMs, discuss how these features may relate to the role of these proteins in mediating cell adhesion and cell signaling events, and finally consider the evolutionary origins of this family of proteins.
Abstract 3788: Sensitive detection of oncoviruses integrated into a comprehensive tumor immuno-genomics platform (2019)

IntroductionHPV, HBV, HCV and EBV viruses are causally linked to over 11% of cancers worldwide while KSHV, HTLV and MCV are linked to an additional 1%. As use of immunotherapy expands to a broader variety of cancers, it is important to understand how these oncoviruses may be impacting the overall immune response in patients as part of the tumor and tumor microenvironment. However, typical cancer diagnostic and genomic biomarker assays do not include oncovirus detection.MethodsTo enable detection of these oncoviruses, we have developed ImmunoID NeXT, a novel augmented exome and transcriptome based platform that comprehensively characterizes tumor and tumor microenvironment from a single sample. As part of the platform assay design we developed targeting for the following oncoviruses: HPV, HBV, HCV, EBV, KSHV and HTLV. Furthermore we developed analytics for detecting these viruses from both the DNA and RNA data. To test the ability of the platform to detect these oncoviruses, we identified a set of 11 EBV cell lines from Coriell in which EBV was used as a transformant. We obtained another 23 cell lines from ATCC containing HPV16, HPV18, HPV45, HPV68, HBV, EBV, KSHV, HTLV1 and HTLV2 in which the oncoviruses were known to be in the tumors from which the cell lines were created. We have also started running a series a FFPE tumor samples of unknown status. We extracted DNA and RNA from all these samples, made libraries and sequenced them on a NovaSeq to 30G. High quality read counts were computed for all targeted oncoviruses.ResultsWe detected EBV in all the Coriell cell lines in both DNA and RNA indicating strong sensitivity of the platform. Wide dynamic range suggests quantification may be possible as well. In the DNA there was no signal from any other oncovirus indicating high specificity. In the ATCC samples we detected 23 out of 23 oncoviruses expected in both the DNA and RNA. We detected all the different types of oncoviruses that we targeted except for HCV because it wasn’t in any sample. In all but one case the signals were strong. False positive detections appear to be rare. Much less than 1% of the overall exome/transcriptome reads map to oncoviruses in all cases.ConclusionsOncovirus detection integrated into an augmented exome and transcriptome assay is sensitive and specific. Oncoviral characterization of the tumor as part of a comprehensive tumor immunogenomics platform can serve and an important additional biomarker for understanding immunotherapy response.Citation Format: Gabor Bartha, Robin Li, Shujun Luo, John West, Richard Chen. Sensitive detection of oncoviruses integrated into a comprehensive tumor immuno-genomics platform [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3788.
Thermal effects in photothermal spectroscopy and photothermal imaging (1983)

The effect of thermal parameters on photothermal spectroscopy and photothermal imaging for certain types of spatially heterogeneous samples has been studied. Results have been obtained for both photoacoustic and photothermal deflection modes of detection. Specific attention has been paid to optical saturation in samples whose properties exhibit gradual spatial changes and to the dependence of the photothermal signal on the individual thermal parameters. Most photothermal spectroscopy has been done using thermally homogeneous samples, and most photothermal imaging using optically saturated samples. In this paper, these limitations are relaxed, and the photothermal signal is assumed to depend simultaneously on gradual spatial variations in the optical absorption coefficient, thermal conductivity, and thermal capacity of the sample.
Sorbent isolation and elution with an immiscible eluent in flow injection analysis (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSorbent isolation and elution with an immiscible eluent in flow injection analysisWei. Lei, Purnendu K. Dasgupta, Jorge L. Lopez, and Don C. OlsonCite this: Anal. Chem. 1989, 61, 5, 496–499Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ac00180a024https://doi.org/10.1021/ac00180a024research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of Scarabaeus micans Drury and taxonomic notes on Dicronorhina Hope, with description of a new species (Coleoptera, Scarabaeidae, Cetoniinae) (2011)

The complex of Dicronorhina Hope taxa without cretaceous marks on head and body (âmicans groupâ) is here diagnosed, discussed and revised. The type species of the genus, Scarabaeus micans Drury, 1773, is identified and re-described. D. johnstoni Waterhouse, 1902, is raised from the synonymy with D. micans and recognized as a bona species. D. kouensis Legrand et al., 2006 (pars, specimens from Burkina Faso and North Benin), is ranked subspecifically under D. micans. D. cavifrons, Westwood, 1843, is confirmed bona species. D. morettoi, nova species, is described from the ComoÃ© National Park in North-East Ivory Coast. The characters useful for diagnosis are identified and discussed, and a key to all species and subspecies presented. It is found that the main diagnostic characters (head structure and armature; parameral apophyses) form complete transitions in a West-to-East geographic cline. A phylogenetic interpretation of these character states is presented. The valid species and subspecies of Dicronorhina Hope, micans group, are listed below: 1. D. micans (Drury, 1773) - s. str. Drury, 1773; - ssp. kouensis Legrand et al., 2006, stat. rev.; 2. D. cavifrons Westwood, 1843; 3. D. johnstoni Waterhouse, 1902, bona species; 4. D. morettoi, nova species.
Genética. Examen de problemas del primer parcial. Grupo B (2010)

s) y la flor magenta (R) o rosa (r).Se realiz un cruce entre una planta homozigota recesiva y otra triple heterozigota para estos genes, obtenindose los resultados de la tabla.Dibuja en 1A un mapa gentico que refleje todas las distancias que se puedan calcular, en cM.Determina si hay interferencia e indica su valor en 1B.Explica en 1C por qu las distancias calculadas entre los genes no son aditivas.Indica en 1D los alelos presentes en cada cromosoma homlogo de la planta parental heterozigota.
Strategies for Overcoming PCR Inhibition (2008)

INTRODUCTIONThe use of conventional and real-time PCR is to some extent restricted by the presence of PCR inhibitors. This is particularly so when the techniques are applied directly to complex biological samples such as clinical, environmental, or food samples for the detection of microorganisms. PCR inhibitors can originate from the sample itself, or as a result of the method used to collect or otherwise prepare the sample. Either way, inhibitors can dramatically reduce the sensitivity and amplification efficiency of PCR. This article discusses methods of reducing inhibition and designing reliable and sensitive conventional and real-time PCR experiments.
Dead Time in the LAr Calorimeter Front-End Readout (2002)

We present readout time, latency, buffering, and dead-time calculations for the switched capacitor array controllers of the LAr calorimeter. The dead time is compared with algorithms for the dead-time generation in the level-1 central trigger processor.
Vasopressin conformational fluctuations: A molecular dynamics study (1988)

Abstract Molecular dynamics simulations have been used to study the conformational fluctuations of the oligopeptide hormone vasopressin. Starting coordinates for these simulations were built upon the crystal structure of pressinoic acid, the cyclic ring moiety of vasopressin, recently determined by x‐ray diffraction. Coordinates for the additional tripeptide “tail” of vasopressin were selected by arbitrary positioning of this segment using interactive computer graphics. Two such starting configurations were minimized to relax strains, and long dynamics simulations (20 and 40 ps) in vacuo were then conducted following extensive heating and equilibration sequences (36 ps). In these studies, vasopressin was found to undergo few substantial conformational changes at 300 K on the time scale simulated, in contrast to the results of a shorter previous simulation, but comparable structural transitions were observed during the equilibration periods. The pressinoic acid structure was found to be a reasonably stable possible conformation for vasopressin in vacuum on this time scale.
Bandwidth Variable Transmitter for Software Defined Networks (2017)

We review the architecture of Bandwidth Variable Transmitter designed for Software Defined Networks. We focus on 10-100Gbit/s elastic coherent transmission performances and high speed switching time enabling SDN controlled zero packet loss operation.
A Multicenter Randomized Phase II Trial of Mapatumumab, a TRAIL-R1 Agonist Monoclonal Antibody, In Combination with Bortezomib In Patients with Relapsed/Refractory Multiple Myeloma (MM) (2010)

Abstract Abstract 5031 Mapatumumab, a fully human monoclonal antibody, targets and activates the TRAIL-R1 receptor. We conducted this randomized, controlled phase II trial to evaluate the efficacy and safety of mapatumumab in combination with bortezomib in subjects with relapsed/refractory MM. Response was evaluated using the Bladé criteria. Patients were required to have a measurable serum and/or urine M-protein and have failed 1 or 2 prior therapies for MM. Patients were excluded if they had received prior bortezomib. Patients were randomly assigned to Arm A, 1.3 mg/m2 bortezomib (days 1, 4, 8, 11) every 21 days; Arm B10, bortezomib + 10 mg/kg mapatumumab (day 1) every 21 days; or Arm B20, bortezomib + 20 mg/kg mapatumumab (day 1) every 21 days. Cycles were repeated every 21 days for a maximum of 17 cycles (1 year), progressive disease or unacceptable toxicity. Subjects with complete response (CR) were treated for an additional 2 cycles after documentation of CR (not to exceed 17) and then followed. A total of 104 subjects from 4 countries were randomly assigned to the treatment arms. The addition of mapatumumab to bortezomib did not increase the response rate, progression-free survival (PFS) or duration of response compared to bortezomib alone. Adverse events were generally balanced across treatment groups; there was no evidence that mapatumumab exacerbated toxicities associated with bortezomib. As expected, the most common toxicities were hematological and peripheral neuropathies. The results do not support further evaluation of mapatumumab in combination with bortezomib in patients with advanced MM. Additional trials of mapatumumab in other indications are on-going. Arm A (n= 35) Arm B10 (n=33) Arm B20 (n=36) CR 0 0 2 PR 18 10 17 CR + PR n (%) 18 (51.4) 10 (30.3) p=0.08a 19 (52.8) p=0.91b Median PFS mo (95% CI) 8.7 (7.6, 10.0) 4.7 (2.5, 7.4) p=0.29a 5.7 (5.2, 8.9) p=0.21b Median Duration of Response mo (range) 8.5 (6.9, 14.2) 9.3 (3.9, 16.1) p=0.92a 7.6 (4.3, 8.8) p=0.41b a P value for comparison of Arm A with Arm B10 b P value for comparison of Arm A with Arm B20 Disclosures: Gallant: Human Genome Sciences, Inc.: Employment, Equity Ownership. Kumm:Human Genome Sciences, Inc.: Employment, Equity Ownership. Klein:Human Genome Sciences, Inc.: Employment, Equity Ownership.
The impact of visual attributes on online image diffusion (2014)

Little is known on how visual content affects the popularity on social networks, despite images being now ubiquitous on the Web, and currently accounting for a considerable fraction of all content shared. Existing art on image sharing focuses mainly on non-visual attributes. In this work we take a complementary approach, and investigate resharing from a mainly visual perspective. Two sets of visual features are proposed, encoding both aesthetical properties (brightness, contrast, sharpness, etc.), and semantical content (concepts represented by the images). We collected data from a large image-sharing service (Pinterest) and evaluated the predictive power of different features on popularity (number of reshares). We found that visual properties have low predictive power compared that of social cues. However, after factoring-out social influence, visual features show considerable predictive power, especially for images with higher exposure, with over 3:1 accuracy odds when classifying highly exposed images between very popular and unpopular.
Anti‐basal ganglia antibodies in PANDAS (2004)

An autoimmune-mediated mechanism involving molecular mimicry has been proposed for a variety of pediatric movement disorders that occur after a streptococcal infection. In this study, anti-basal ganglia antibodies (ABGA) were measured in 15 children with the diagnosis of pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and compared with those in 15 controls. ELISA and Western immunoblotting (WB) methods were used to detect ABGA against supernatant (S1), pellet (P2), and synaptosomal preparations from adult postmortem caudate, putamen, and globus pallidus. ELISA optical density values did not differ between PANDAS patients and controls across all preparations. Immunoblotting identified multiple bands in all subjects with no differences in the number of bands or their total density. Discriminant analysis, used to assess mean binding patterns, showed that PANDAS patients differed from controls only for the caudate S1 fraction (Wilks' lambda = 0.0236, P < 0.0002), with PANDAS-primarily tic subjects providing the greatest discrimination. Among the epitopes contributing to differences between PANDAS and control in the caudate S1 fraction, mean binding to the epitope at 183 kDa was the most different between groups. In conclusion, ELISA measurements do not differentiate between PANDAS and controls, suggesting a lack of major antibody changes in this disorder. Further immunoblot analyses using a caudate supernatant fraction are required to completely exclude the possibility of minor antibody repertoire differences in PANDAS subjects, especially in those who primarily have tics.
Fully Open-Access Passive Dry Electrodes BIOADC: Open-Electroencephalography (EEG) Re-Invented (2019)

The Open-electroencephalography (EEG) framework is a popular platform to enable EEG measurements and general purposes Brain Computer Interface experimentations. However, the current platform is limited by the number of available channels and electrode compatibility. In this paper we present a fully configurable platform with up to 32 EEG channels and compatibility with virtually any kind of passive electrodes including textile, rubber and contactless electrodes. Together with the full hardware details, results and performance on a single volunteer participant (limited to alpha wave elicitation), we present the brain computer interface (BCI)2000 EEG source driver together with source code as well as the compiled (.exe). In addition, all the necessary device firmware, gerbers and bill of materials for the full reproducibility of the presented hardware is included. Furthermore, the end user can vary the dry-electrode reference circuitry, circuit bandwidth as well as sample rate to adapt the device to other generalized biopotential measurements. Although, not implemented in the tested prototype, the Biomedical Analogue to Digital Converter BIOADC naturally supports SPI communication for an additional 32 channels including the gain controller. In the appendix we describe the necessary modification to the presented hardware to enable this function.
A single molecule magnet behaviour in a D<sub>3h</sub>symmetry Dy(<scp>iii</scp>) complex involving a quinone–tetrathiafulvalene–quinone bridge (2011)

A Dy(III)-based dinuclear complex was synthesised and characterised by X-ray diffraction on single crystal and magnetic investigations. Dynamic magnetic measurements reveal a single molecule magnet behaviour for 1 which can be described as two single-ion magnets in a D(3h) local symmetry bridged by an acceptor-donor-acceptor ligand.
The theory of coacervation (1950)

C. H. Bamford and H. Tompa, Trans. Faraday Soc., 1950, 46, 310 DOI: 10.1039/TF9504600310
ChemInform Abstract: PHOTOCHEMISCHE UMWANDLUNGEN 35. MITT. CYCLOADDITION AN DAS TETRACYCLO(4,2,0,0(2,8),0(5,7))OCTAN‐SYST. (1970)

Abstract Bei ‐20°C lagert sich in konz. ätherischer Lösung bei Belichtung das Bicyclodien (I) zum Tetracyclus (II) um, der schon bei 19°C mit einer Halbwertzeit von 12 Min. (I) zurückliefert.(II) addiert stereospezifisch das Äthen (III) ′unter Bildung des Tricyclus (IV) (70‐79% Ausbeute auf 30% Umsatz) und das Acetylen (V) unter Bildung des Tricyclus (VI) (80‐87% auf 30% Umsatz).