gebhart/patrepeval huggingface dataset:
Synthesis of β-Disulfones from Sulfonyl Fluorides and Organometallic Compounds (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of β-Disulfones from Sulfonyl Fluorides and Organometallic CompoundsHaruko Fukuda, Forrest J. Frank, and William E. TruceCite this: J. Org. Chem. 1963, 28, 5, 1420Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://pubs.acs.org/doi/10.1021/jo01040a526https://doi.org/10.1021/jo01040a526research-articleACS PublicationsRequest reuse permissionsArticle Views337Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Addition of Pentoxifylline plus Nifedipine to Chemotherapy in Patients with Cisplatin-Resistant Cancers of the Lung and Other Sites (1994)

Eight evaluable patients with cisplatin-resistant non-small cell lung cancer (6 patients), small cell lung cancer (1 patient), or both breast and ovarian cancer (1 patient) were entered on a study to determine whether the addition of nifedipine plus pentoxifylline to cisplatin-based chemotherapy would result in increased chemotherapy efficacy. No patient responded to treatment. Myelosuppression may have been augmented by the nifedipine and pentoxifylline (median granulocyte nadir, 0.3 x 10(9)/L). Two patients developed febrile neutropenia. Nifedipine and pentoxifylline had to be stopped in two evaluable patients due to hypotension, and three additional inevaluable patients withdrew from the study due to nifedipine-pentoxifylline toxicity before receiving their chemotherapy. There was no indication that other types of chemotherapy toxicity were increased by the addition of nifedipine and pentoxifylline. A major problem with the strategy followed in this protocol was that patients whose tumors had failed to respond to cisplatin-based regimens were often too ill to tolerate additional cisplatin, particularly when accompanied by nifedipine-associated hypotension.
ESEU-a hardware architecture for fast image generation (2002)

A special-purpose hardware architecture architecture called the expandable shading engine unit (ESEU) for fast image generation and its corresponding graphics system configuration are described. Each ESEU has three major functional blocks: linear interpolator, multipliers, and edge painting tree. The linear interpolator with a coupled binary tree architecture interpolates the functional values of two end points which are view-depth values or color intensities. Two multipliers compute the input values of the interpolator in parallel. A mask pattern for the removal of data outside the given span is generated by the edge painting tree. This prototype ESEU is designed to process the data for 64 pixels. Estimated performance is about 570 K scanline-commands/s. Since there are no interconnections among ESEUs, system can be easily expanded. The bit-serial operation of ESEU guarantees the feasibility of its VLSI implementation at a reasonable cost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Maximum Margin Principal Components (2017)

Principal Component Analysis (PCA) is a very successful dimensionality reduction technique, widely used in predictive modeling. A key factor in its widespread use in this domain is the fact that the projection of a dataset onto its first $K$ principal components minimizes the sum of squared errors between the original data and the projected data over all possible rank $K$ projections. Thus, PCA provides optimal low-rank representations of data for least-squares linear regression under standard modeling assumptions. On the other hand, when the loss function for a prediction problem is not the least-squares error, PCA is typically a heuristic choice of dimensionality reduction -- in particular for classification problems under the zero-one loss. In this paper we target classification problems by proposing a straightforward alternative to PCA that aims to minimize the difference in margin distribution between the original and the projected data. Extensive experiments show that our simple approach typically outperforms PCA on any particular dataset, in terms of classification error, though this difference is not always statistically significant, and despite being a filter method is frequently competitive with Partial Least Squares (PLS) and Lasso on a wide range of datasets.
Reversal of Oxymorphone Sedation by Naloxone, Nalmefene, and Butorphanol (1990)

The effects of naloxone (0.4 mg and 1.2 mg intravenously [IV]), nalmefene (0.03 mg/kg IV) and butorphanol (0.2 mg/kg IV and 0.4 mg/kg IV) on oxymorphone-induced sedation were studied in six dogs over a 4-hour observation period. The same dogs were observed for 4 hours untreated (unsedated control) and with oxymorphone sedation followed by saline solution (sedated control). The reversal drug or saline placebo was administered IV 20 minutes after oxymorphone (4.5 mg IV). Blinded observers evaluated the dogs for positional and attitudinal responses, heart rate, and respiratory rate. Sedated dogs treated with nalmefene most closely resembled unsedated dogs in all observed variables. Naloxone was most effective when administered at the higher dose. Mild renarcotization occurred in two dogs at hour 2, even after the higher naloxone dose. Residual sedation was observed in all dogs treated with 0.4 mg naloxone. Butorphanol resulted in partial reversal of sedation at both dosage levels. However, the degree of sedation was significantly less than that observed in the saline-treated controls, and it appeared that 0.4 mg/kg butorphanol may be clinically useful for opiate reversal in some situations.
The effect of desipramine on body weight in depression. (1987)

Twenty-six patients with major depressive disorder were treated with desipramine for 4 weeks to determine the effect of the drug on body weight. Responders to desipramine showed a weight gain only at Weeks 3 and 4; nonresponders had a nonsignificant loss of weight. The increase in body weight of the responders was independent of dosage, sex, and hospitalization status. These findings suggest that the small increase in body weight that occurs in patients taking desipramine is associated with treatment response. In addition, desipramine may be a valuable treatment alternative for those patients in whom excessive weight gain is undesirable.
Laboratory evaluations of three dentifrices with polishing or brushing. (1998)

The purpose of this study was to determine the depth of deposit removal of three dentifrices using a dental felt polishing tip or an Oral-B P 35 toothbrush. The dentifrices were compared using a laboratory method which simulates clinical tooth polishing or toothbrushing procedures, and utilizes a pressure-sensitive paper that records the depth of deposit removal. Each polishing time was conducted for five seconds; toothbrushing time was 15 seconds. Both polishing and toothbrushing were performed at a weight of 250 grams. Depth of Deposit Removal (DDR) was recorded using a 0-4 scale from a comparative color chart. The dentifrices evaluated were Arm & Hammer Dental Care, Colgate Regular, and Crest Regular. Twenty-four replicates of each dentifrice, tested undiluted, were performed. Results indicated that dentifrice efficacy was ranked numerically as Arm & Hammer Dental Care > Colgate Regular > Crest Regular. In all of the assays the Arm & Hammer Dental Care dentifrice had significantly (p < 0.01-0.001) higher DDR mean values compared to the Colgate Regular and Crest Regular dentifrices. The Colgate Regular dentifrice was significantly (p < 0.01-0.001) superior to the Crest Regular dentifrice in the assays conducted.
Quantitative Measurement with Scanning Thermal Microscope by Preventing the Distortion Due to the Heat Transfer through the Air (2011)

Because of its high spatial resolution, scanning thermal microscopy (SThM) has been developed quite actively and applied in such diverse areas as microelectronics, optoelectronics, polymers, and carbon nanotubes for more than a decade since the 1990s. However, despite its long history and diverse areas of application, surprisingly, no quantitative profiling method has been established yet. This is mostly due to the nonlocal nature of measurement by conventional SThM: the signal measured by SThM is induced not only from the local heat flux through the tip-sample thermal contact but also (and mostly) from the heat flux through the air gap between the sample and the SThM probe. In this study, a rigorous but simple and practical theory for quantitative SThM for local measurement is established and verified experimentally using high-performance SThM probes. The development of quantitative SThM will make possible new breakthroughs in diverse fields of nanothermal science and engineering.
Professional Achievement in Social Work (1987)

The authors report on a study of the professional achievements of 719 recently graduated California MSWs. Respondents are assigned an achievement score which is an index based on responses to seven questions. The scores of low achievers and high achievers are compared to analyze associations with: validating factors (e.g., salary), personal factors (race and gender), and pre-MSW factors (e.g., undergraduate education).
Uniquely Identifiable Tamper-Evident Device Using Coupling between Subwavelength Gratings (2015)

Reliability and sensitive information protection are critical aspects of integrated circuits. A novel technique using near-field evanescent wave coupling from two subwavelength gratings (SWGs), with the input laser source delivered through an optical fiber is presented for tamper evidence of electronic components. The first grating of the pair of coupled subwavelength gratings (CSWGs) was milled directly on the output facet of the silica fiber using focused ion beam (FIB) etching. The second grating was patterned using e-beam lithography and etched into a glass substrate using reactive ion etching (RIE). The slightest intrusion attempt would separate the CSWGs and eliminate near-field coupling between the gratings. Tampering, therefore, would become evident. Computer simulations guided the design for optimal operation of the security solution. The physical dimensions of the SWGs, i.e. period and thickness, were optimized, for a 650 nm illuminating wavelength. The optimal dimensions resulted in a 560 nm grating period for the first grating etched in the silica optical fiber and 420 nm for the second grating etched in borosilicate glass. The incident light beam had a half-width at half-maximum (HWHM) of at least 7 µm to allow discernible higher transmission orders, and a HWHM of 28 µm for minimum noise. The minimum number of individual grating lines present on the optical fiber facet was identified as 15 lines. Grating rotation due to the cylindrical geometry of the fiber resulted in a rotation of the far-field pattern, corresponding to the rotation angle of moiré fringes. With the goal of later adding authentication to tamper evidence, the concept of CSWGs signature was also modeled by introducing random and planned variations in the glass grating. The fiber was placed on a stage supported by a nanomanipulator, which permitted three-dimensional displacement while maintaining the fiber tip normal to the surface of the glass substrate. A 650 nm diode laser was fixed to a translation mount that transmitted the light source through the optical fiber, and the output intensity was measured using a silicon photodiode. The evanescent wave coupling output results for the CSWGs were measured and compared to the simulation results.
Nurses and doctorates (2002)

Nursing needs more research fellowships, says Claire Hale
Synthesis of Some New Mannich Bases of N-(4-Hydroxy-3 -methoxy-benzylidene)-4-methoxy benzoic acid hydrazide as Potential Biologically Active Agents (1980)

Department of Chemistry, Lucknow University, Lucknow-226 007 <em>Manuscript received 23 March 1979, revised 25 September 1979, accepted 9 July 1980</em> A series of new Mannich bases from N-(4<em>'</em>-hydroxy-3<em>'</em>-methoxy-benzylldene)-4- methoxy benzoic acid hydrazide has been synthesised and evaluated for their antibacterial and antiviral activities.
Surface Film Thickness Determination by Reflectance Measurements (1973)

The thicknesses of UO(2) films from 100 A to 1800 A on uranium substrates were determined from reflectance measurements in the visible region. The reflectance measurements on the U-UO(2) system were analyzed by two different methods to determine film thicknesses. In the first method, film thicknesses were determined by comparing theoretical reflectance calculations with the experimental reflectance measurements. In the second method, film thicknesses were determined by obtaining the best match of the clorimetric properties (wavelength, excitation purity, and luminous reflectance) of the sample with the colorimetric properties of a predetermined film thickness calibration curve.
Will Antirheumatic Treatment Improve Cardiovascular Outcomes in Patients with Rheumatoid Arthritis? (2014)

In recent years, the scientific community has gained significant insight into the complex interaction between inflammation and the cardiovascular system in patients with rheumatoid arthritis (RA), which leads to increased cardiovascular (CV) morbidity and mortality in these patients. Our common understanding of this association is that persistent inflammation contributes to the development of premature atherosclerosis. Consequently, the question arises whether control of inflammation with antirheumatic treatment will be able to improve CV outcome. While there are a lot of data that demonstrate improvement of numerous CV surrogate markers in patients treated with virtually all antirheumatic drug classes, there is much less information about the possible translation of these beneficial effects into improved CV outcome. In summary, the published evidence suggests that tumor necrosis factor (TNF) alpha inhibitors may improve CV outcome. The same is true for methotrexate (MTX). However, it is not clear whether MTX works via suppression of inflammation or through drug specific mechanisms. For other traditional disease-modifying antirheumatic drugs and biologic therapies, there are no convincing data for improved CV outcome. Only a few drugs (glucocorticoids and NSAIDs) have been associated with increased CV risk. Treating RA aggressively, as recommended by current guidelines, is likely to have a beneficial effect on CV outcomes.
Process Model for Cloud Service Engineering (2011)

Cloud computing is a model for on-demand and convenient network access to a shared pool of computing resources that can be easily used and provide services with the minimal management effort. Cloud engineering is a discipline for the systematic and scientifically development of the good and economic cloud that focus on providing cloud services to requested users. In order to create the economical and good quality cloud, the structure of cloud engineering is important. This structure consists of four components: Base, Cloud development life cycle (CDLC), Tools and Techniques, Management. Cloud Development life cycle (CDLC) is one of the important component of structure which has iterated life cycle model for development, deployment and delivery of cloud. CDLC has six phases which is flexible, simple in nature and having feedback to first phase. These phases are organized in a linear order and processed in an isolated manner. This paper discusses each phase of CDLC in detail one by one.
Response of Container-grown ‘Hicks’ Yew to Preplant Chilling and Postplant Night Lighting (1983)

Abstract Preplant chilling of rooted cuttings and postplant night lighting influenced the growth of ‘Hicks’ yew ( Taxus × media Rehd. ‘Hicksii’). Supplemental light from high-pressure sodium (HPS) lamps, provided during the first year, enhanced shoot length and number in the first year, but not in the second. Compared to natural light, HPS increased shoot length 3 to 5 times and shoot number 3 and 4 times in the first year. The influence of incandescent light on growth was less, being significant on unchilled but not chilled plants, and not beneficial when continued for 2 years. In the second year, plants under natural light grew as much or more than plants under either HPS or incandescent light. The trend of increased shoot length in the first year by chilled plants under natural light was not evident for lighted plants, nor was there any benefit of chilling on shoot number. A trend for less growth in the second year by chilled plants was evident. The delay in initiation and development of buds on accelerated plants had an adverse effect on growth the second year.
Silicon MOSFETs, the microwave device technology for the 1990s (2002)

Silicon MOSFET technology using 1.5- mu m gate lengths has demonstrated excellent performance for 900-MHz applications. Circuit results for low-noise amplifiers, power amplifiers, mixers, and oscillators using this technology are discussed in comparison to other device technologies. Device results for 0.6- mu m-gate-length devices showing the microwave performance of silicon MOS transistors are discussed. These results, together with scaling predictions, indicate that microwave silicon MOSFETs will play a major role in the 1990s. The performance of devices with 0.6- mu m gate lengths indicates that silicon MOS will be the FET technology of choice for applications below 3 GHz. Advantages such as high voltage characteristics, low thermal conductivity of silicon, and the high operating junction temperature make silicon MOS a technology with immense potential for high-voltage X-band power applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A highly efficient CMOS line driver with 80-dB linearity for ISDN U-interface applications (1992)

A fully differential CMOS line driver intended for ISDN U-interface applications is reported. Design details with emphasis on a novel high-swing output stage are presented. The output stage incorporates a class-B stage in parallel with the conventional class-H/B structure, allowing high linearity, high power efficiency, and well-controlled quiescent current. The prototype line driver exhibits total harmonic distortion of -83 dB for an output voltage swing of 7 V/sub pp-diff/. It maintains linearity on the order of 78 dB for nearly rail-to-rail output voltage swing of 9 V/sub pp-diff/ for signal frequencies of up to 40 kHz. The chip, built in a 0.9- mu m technology, occupies an active area of 0.63 mm/sup 2/. It operates from a single 5-V power supply and dissipates 20-mW quiescent power.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
T cell-depleted allogeneic bone marrow transplantation in a case of childhood idiopathic myelofibrosis. (1987)

An 11-year-old boy developed primary myelofibrosis. Nine months after diagnosis he received high-dose chemoradiotherapy followed by T cell-depleted allogeneic bone marrow transplantation as primary therapy. Sixteen months after grafting the patient is well, with reversal of the marrow sclerosis and no evidence of chronic graft-versus-host disease.
Thermal and mechanical aspects for designing micromachined low-power gas sensors (1997)

Metal oxide gas sensors have to be heated during operation. Ideally they should have low power consumption and a uniform temperature distribution over the sensitive area. Thermal isolation is achieved by locating the sensitive element on thin free-standing membranes fabricated by means of micromachining of silicon. Uniformity of the temperature is helpful for discriminating different gases and, thus, increasing the selectivity. This can be achieved by careful design of the heater or by additional structures. Micromachined test structures have been fabricated, their mechanical strength and thermal behaviour have been determined and the results have been correlated with extensive FEM studies.
A Robust High Capacity Information Hiding Algorithm Based on DCT High Frequency Domain (2009)

Improving hiding capacity and resisting compression ability is an important problem in information hiding application. In this paper, invariance of JPEG compression is analyzed firstly. Then, according to invariance of JPEG compression, an information hiding algorithm which can embed information in DCT median and high frequency coefficients is proposed. Information embedding capacity adaptively is determined by smooth state of subblocks. Hence hiding capacity can be increased under the condition of satisfying imperceptibility. The algorithm has strong robustness against lossy compression within default quality factor. Besides, experiments show that this information hiding algorithm has a certain degree of antinoise ability.
Recognizing and managing on toxicities in cancer immunotherapy (2017)

Over the past 4 years, cancer immunotherapy has significantly prolonged survival time of patients with prostate cancer, melanoma, lung cancer, and liver cancer, but its side effects are also impressive. Different types of the immune therapeutic agents have different on-target or off-target toxicity due to high affinity or weak specificity, respectively. Treatment toxicity spectrums vary greatly even in patients with the same type of cancer. Common toxicities are fevers, chills, diarrhea colitis, maculopapular rash, hepatitis, and hormone gland disorder; therefore, routine monitoring of thyroid function, liver function, renal function, and complete blood count are absolutely necessary once treatment begins. Some side effects are reversible, and can be processed through the standard medicines. However, serious toxicities are lethal, which should be frequently followed-up, identified at an early stage and immediately symptomatic treated by high-dose immunosuppressors. In this case, thereafter, the same agent should not be challenged again.
연구논문 : 마을만들기 사례분석을 통한 지방자치단체의 역할에 관한 연구 -한국과 일본사례를 중심으로- (2012)

우리의 전통사회는 유기적이며 지속적인 성격을 지녔으나 빠른 속도로 변화하고 있는 현대사회는 자본주의사회로 도래하면서 산업화, 도시과정에서 지역공동체의 붕괴를 경험했다. 이에 따라 지역사회 통합에 대한 관심이 생겨나면서 공동체를 회복시켜 삶의 질을 높여야 한다는 움직임이 일어나기 시작했고 이에 마을만들기에 대한 관심이 증가했다. 마을만들기는 정주환경과 삶의 문화를 잃어버린 우리 도시에 대한 문제의식과 반성에서 출발하고 있다. 여기서 문제점은 지금까지 전개되어온 선진사례에서 나타난 마을만들기의 성공적 사례들이 과연 얼마만큼 우리들의 실정과 부합되어 왔으며, 향후에 어떻게 전개되어야 할 것인가에 대한 반성이 필요하다. 또한 다양한 접근방식을 포함하여 추진단계와 방식, 참여주체 또한 명확하게 정립된 필요성이 있다. 따라서 본 연구는 향후에 전개되어야 할 마을만들기 운동의 활성화 방안을 모색해 보고자 한다.