gebhart/patrepeval huggingface dataset:
eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia (2000)

Pulmonary hypertension is characterized by structural and morphological changes to the lung vasculature. To determine the potential role of nitric oxide in the vascular remodeling induced by hypoxia, we exposed wild-type [WT(+/+)] and endothelial nitric oxide synthase (eNOS)-deficient [(-/-)] mice to normoxia or hypoxia (10% O(2)) for 2, 4, and 6 days or for 3 wk. Smooth muscle alpha-actin and von Willebrand factor immunohistochemistry revealed significantly less muscularization of small vessels in hypoxic eNOS(-/-) mouse lungs than in WT(+/+) mouse lungs at early time points, a finding that correlated with decreases in proliferating vascular cells (5-bromo-2'-deoxyuridine positive) at 4 and 6 days of hypoxia in the eNOS(-/-) mice. After 3 wk of hypoxia, both mouse types exhibited similar percentages of muscularized small vessels; however, only the WT(+/+) mice exhibited an increase in the percentage of fully muscularized vessels and increased vessel wall thickness. eNOS protein expression was increased in hypoxic WT(+/+) mouse lung homogenates at all time points examined, with significantly increased percentages of small vessels expressing eNOS protein after 3 wk. These results indicate that eNOS deficiency causes decreased muscularization of small pulmonary vessels in hypoxia, likely attributable to the decrease in vascular cell proliferation observed in these mice.
Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy. (1997)

Hepatocellular secretion of bile salts into the biliary space induces phospholipid and cholesterol secretion, but the mechanism for integrated lipid secretion is poorly understood. Knockout mice unable to make the canalicular membrane mdr2 P-glycoprotein exhibit normal rates of bile salt secretion, yet are virtually incapable of secreting biliary phospholipid and cholesterol. As the mdr2 P-glycoprotein is thought to mediate transmembrane movement of phospholipid molecules, this mouse model was used to examine the mechanism for biliary phospholipid secretion. In wild-type mdr2 (+/+) mice, ultrarapid cryofixation of livers in situ revealed abundant unilamellar lipid vesicles within bile canalicular lumina. Although 74% of vesicles were adherent to the external aspect of the canalicular plasma membrane, bilayer exocytosis was not observed. Vesicle numbers in mdr2 (+/-) and (-/-) mice were 55 and 12% of wild-type levels, respectively. In a strain of mdr2 (-/-) mice which had been "rescued" by heterozygous genomic insertion of the MDR3 gene, the human homologue of the murine mdr2 gene, vesicle numbers returned to 95% of wild-type levels. Our findings indicate that biliary phospholipid is secreted as vesicles by a process largely dependent on the action of the murine mdr2 P-glycoprotein or human MDR3 P-glycoprotein. We conclude that mdr2-mediated phospholipid translocation from the internal to external hemileaflet of the canalicular membrane permits exovesiculation of the external hemileaflet, a vesiculation process promoted by the detergent environment of the bile canalicular lumen.
Contemporary Character as Crisis Adaptation (1974)

Rapid changes in our society produce crises which need adapting to. Problems emerging in this process and forms of adaption to them are discussed in terms of ego functions, ego ideals, the superego, and resultant character structure. Short- and long-range measures for crisis intervention and future social planning are advanced.
Novel technique for ferrimagnetic resonance measurements (1992)

The ferrimagnetic resonance (FMR) linewidth, Delta H, and resonant magnetic field of single-crystal (Mn-doped) Ba/sub 2/Zn/sub 2/Fe/sub 12/O/sub 22/ were measured as a function of frequency from 2 to 20 GHz. These measurements were performed utilizing a slot-coplanar device. The linewidth and resonant frequency measurements were found to compare well with those obtained using a standard FMR cavity technique, and the data were also in agreement with the behavior predicted by Landau-Lifshitz theory with the damping parameter alpha =0.0014.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pinpointing Fluid Entries in Producing Wells (1999)

A new real-time production-logging tool with memory has been developed on the basis of a better understanding of downhole fluid dynamics. New sensor technology and a design applicable to high-deviation wells allow operators to perform wireline interventions that were not possible previously.
Reactions of Aerated N-Dodecane Liquid Flowing over Heated Metal Tubes (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Aerated N-Dodecane Liquid Flowing over Heated Metal TubesRobert N. Hazlett, James M. Hall, and Martha MatsonCite this: Ind. Eng. Chem. Prod. Res. Dev. 1977, 16, 2, 171–177Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/i360062a013https://doi.org/10.1021/i360062a013research-articleACS PublicationsRequest reuse permissionsArticle Views211Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Etude de l'impact des traitements lasers, thermiques et chimiques sur les propriétés diélectriques des substrats céramiques (Al2O3) par des mesures de potentiel de surface (2010)

National audience
Application of photo-electrochemical hydrogen production for autonomous solar based electricity supply (2008)

Utilization of photovoltaic (PV) generated electricity in power systems detached from the public grid usually requires both short term storage for the compensation of day/night cycles as well as long term storage for smoothing the seasonal energy harvest distinctions. Prototype systems relying on an accumulator for short term and a hydrogen path - consisting of electrolyzer, hydrogen tank and hydrogen gas engine based generator (or alternatively a fuel cell) - as long term storage have proven well in various prototype plants. A disadvantage is the electricity based generation of hydrogen for the long term storage path; rather, direct solar hydrogen production using innovative photo-electrochemical (PEC) cells - which are newly available - eases and simplifies both plant design and operation. In the following these photo-electrochemical cells are briefly characterized and their potential exemplary application for the autonomous electricity supply of an industrial plant in several configuration variants is investigated.
Structure of aureobasidin A. (1991)

Aureobasidin A, a new antifungal antibiotic, was isolated from the culture medium of Aureobasidium pullulans R106. Aureobasidin A was a cyclic depsipeptide consisting of eight alpha-amino acid units and one hydroxy acid unit. The structures of the units were found by acid hydrolysis of the antibiotic to be 2(R)-hydroxy-3(R)-methylpentanoic acid, beta-hydroxy-N-methyl-L-valine, N-methyl-L-valine, L-proline, allo-L-isoleucine, N-methyl-L-phenylalanine, L-leucine, and L-phenyl-alanine. The sequence of the units was identified by NMR and FAB-MS of the products from the alkaline hydrolysis of aureobasidin A.
Operating system support for persistent systems: past, present and future (2000)

Since the 1980s, various groups have been constructing systems that support a concept known as orthogonal persistence. These systems support objects whose lifetime is independent of the context in which they were created. The benefits of such systems include greater run-time efficiency, strong semantic guarantees about the existence of data and its type, early error checking, and lower construction costs. However, the implementation of persistent systems has been hindered by the lack of support provided by the operating system. This paper examines the implementation of persistent systems on traditional operating systems and on operating systems that directly support persistence, and looks at current attempts to provide flexible architectures that permit persistence to be provided efficiently above the operating system. Copyright © 2000 John Wiley & Sons, Ltd.
[Activity of different antigenic preparations from the retina to induce experimental auto-immune uveo-retinitis (EAU) in guinea pigs (author's transl)]. (1977)

24 different antigenic preparations from bovine or guinea pig retina and 3 from bovine uvea were tested for their ability to induce uveo-retinitis in guinea pigs. Each animal received one injection into the hind foot pads of 0.1 ml og the tissue preparation mixed with an equal volume of complete Freund's adjuvant. The intensity of the disease was assessed by clinical and histological criteria. Homogenates and extracts from whole guinea pig retina are more active than the same preparations from bovine retina. Autologous retinal extract is slightly more active than homologous in low doses. In bovine retina, the autoantigen(s) is localized in the photoreceptor structures and the pigment epithelium. Bovine uveal preparations seem to be inactive when the epithelium has been removed. Purified outer segments are very active, as well as soluble extracts of outer segments. Highly purified bovine rhodopsin has no immunopathogenic activity. A soluble autoantigen (autoantigen S) has been isolated by preparative isoelectrofocusing from retinas of several species. Autoantigen S from guinea pig induces the disease in guinea pigs at a dose of a few micrograms.
Platinum Complexes (1997)

It is now over 20 years since the platinum-based drug cisplatin (cis-diamminedichloro platinum [II]) was added to the armamentarium available to the oncology physician. Interestingly, the chemical identity of cisplatin was first established in the mid-19th century (and known as Peyrone’s chloride) and, were it not for the well-documented serendipitous observations of Barnett Rosenberg while performing experiments investigating the effects of electric fields on bacteria, its antitumor properties may have remained undiscovered (1). Cisplatin has long been accepted to confer significant antitumor activity against a variety of neoplasms; in particular, as a result of the introduction of cisplatin-containing chemotherapy regimes, over 80% of men presenting with testicular cancer are now cured of their disease (2). Initial studies at the Royal Marsden Hospital (London) by Wiltshaw and Carr also established that cisplatin conferred promising activity against ovarian cancer (3). Combination regimens including cisplatin (typically with cyclophosphamide) generally produce clinical complete remissions in approx 50% of patients with advanced disease. Moreover, long-term followup studies in patients with advanced ovarian cancer have shown that combination chemotherapy containing cisplatin enhanced survival by at least 10% at 5 and 10 yr postdiagnosis compared to the accepted best available drugs of the precisplatin era (4). In addition to these dramatic effects on the long-term survival of cancer sufferers, cisplatin also offers substantial palliative benefit to patients with small-cell lung, bladder, cervical, and head and neck carcinomas (2).
Silicon based nanogap device for studying electrical transport phenomena in molecule–nanoparticle hybrids (2008)

We report the fabrication and characterization of vertical nanogap electrode devices using silicon-on-insulator substrates. Using only standard silicon microelectronic process technology, nanogaps down to 26 nm electrode separation were prepared. Transmission electron microscopy cross-sectional analysis revealed the well defined material architecture of the nanogap, comprising two electrodes of dissimilar geometrical shape. This asymmetry is directly reflected in transport measurements on molecule-nanoparticle hybrid systems formed by self-assembling a monolayer of mercaptohexanol on the electrode surface and the subsequent dielectrophoretic trapping of 30 nm diameter Au nanoparticles. The observed Coulomb staircase I-V characteristic measured at T = 4.2 K is in excellent agreement with theoretical modelling, whereby junction capacitances of the order of a few 10(-18) farad and asymmetric resistances of 30 and 300 MΩ, respectively, are also supported well by our independent estimates for the formed double barrier tunnelling system. We propose our nanoelectrode system for integrating novel functional electronic devices such as molecular junctions or nanoparticle hybrids into existing silicon microelectronic process technology.
Recent Advances in the Chemistry of Heterocarborane Complexes Incorporating s- and p-Block Elements (1997)

ADVERTISEMENT RETURN TO ISSUEPREVArticleRecent Advances in the Chemistry of Heterocarborane Complexes Incorporating s- and p-Block ElementsAnil K. Saxena, John A. Maguire, and Narayan S. HosmaneView Author Information Department of Chemistry, Southern Methodist University, Dallas, Texas 75275Cite this: Chem. Rev. 1997, 97, 6, 2421–2462Publication Date (Web):October 1, 1997Publication History Received11 April 1997Revised9 June 1997Published online1 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/cr9703257https://doi.org/10.1021/cr9703257research-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views681Altmetric-Citations120LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Boron,Chemical structure,Crystal structure,Elements,Metals Get e-Alerts
Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues (1983)

1--Platelet-rich plasma (PRP) from humans, cats, dogs (after addition of 10 microM adrenaline), rabbits and guinea-pigs aggregated in response to sodium arachidonate or 9,11-azo-prostaglandin H2, while PRP obtained from sheep was unresponsive to either agent. 2--The stable thromboxane (Tx) analogues, carbocyclic TxA2 (CTA2) and pinane TxA2 (PTA2) significantly inhibited these aggregatory responses in platelets from humans, dogs and guinea-pigs, while PTA2 but not CTA2 produced significant inhibition in cat platelets. The aggregatory response of PRP from rabbits was not significantly blocked by either analogue. 3--CTA2 and the endoperoxide analogue 9,11-methanoepoxy PGH2 (U-46619) constricted coronary arteries from cats, dogs, rabbits and guinea-pigs, while sheep vessels were unresponsive to either analogue. 4--Vasoconstrictor responses to U-46619 were significantly attenuated by PTA2 in vessels from all species. However, constriction produced by CTA2 was blocked significantly only in vessels from cats, dogs and guinea-pigs. 5--These results demonstrate the species differences which exist in the responsiveness of platelets and coronary arteries to thromboxane and endoperoxide analogues. Furthermore, the results illustrate the importance of species selection in the study of thromboxane antagonists for potential therapeutic use.
Localization of 4q35.2 to the nuclear periphery: is FSHD a nuclear envelope disease? (2004)

Facioscapulohumeral muscular dystrophy (FSHD) may be a new member of the class of neuromuscular diseases (NMD) due to defects in the nuclear envelope. Unlike other NMDs with primary defects in nuclear envelope proteins, however, FSHD may result from inappropriate chromatin interactions at the envelope. 3D Immuno-FISH and a novel method of 3D by 2D analysis using NucProfile were developed to examine nuclear organization of the FSHD genomic region. In contrast to most other telomeres, the FSHD region at 4q35.2 localizes to the nuclear periphery. This localization is consistent in normal myoblasts, myotubes, fibroblasts and lymphoblasts, does not vary significantly throughout the cell cycle, and is independent of chromosome territory effects. The nuclear lamina protein lamin A/C is required for FSHD region chromatin localization to the nuclear envelope, as the association is lost in lamin A/C null fibroblasts. As both normal and affected alleles (deleted for the subtelomeric repeat D4Z4) localize to the nuclear periphery, FSHD likely arises instead from improper interactions with transcription factors or chromatin modifiers at the nuclear envelope. Interestingly, it is not D4Z4 itself that mediates interaction with the envelope, as sequences proximal to D4Z4 (i.e. D4S139) localize closer to the nuclear periphery, perhaps accounting for the chromosome 4 specificity of the disease.
ChemInform Abstract: Selective Dealkylations of Alkyl Aryl Ethers in Heterogeneous Basic Media under Microwave Irradiation. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<i>Saccharomyces cerevisiae</i>Cells with Defective Spindle Pole Body Outer Plaques Accomplish Nuclear Migration via Half-Bridge–organized Microtubules (1998)

Cnm67p, a novel yeast protein, localizes to the microtubule organizing center, the spindle pole body (SPB). Deletion of CNM67 (YNL225c) frequently results in spindle misorientation and impaired nuclear migration, leading to the generation of bi- and multinucleated cells (40%). Electron microscopy indicated that CNM67 is required for proper formation of the SPB outer plaque, a structure that nucleates cytoplasmic (astral) microtubules. Interestingly, cytoplasmic microtubules that are essential for spindle orientation and nuclear migration are still present in cnm67Delta1 cells that lack a detectable outer plaque. These microtubules are attached to the SPB half- bridge throughout the cell cycle. This interaction presumably allows for low-efficiency nuclear migration and thus provides a rescue mechanism in the absence of a functional outer plaque. Although CNM67 is not strictly required for mitosis, it is essential for sporulation. Time-lapse microscopy of cnm67Delta1 cells with green fluorescent protein (GFP)-labeled nuclei indicated that CNM67 is dispensable for nuclear migration (congression) and nuclear fusion during conjugation. This is in agreement with previous data, indicating that cytoplasmic microtubules are organized by the half-bridge during mating.
Significance of hepatitis virus infection in the oncogenic initiation of hepatocellular carcinoma (2016)

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, and DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC.
Position of the fabella relative to the path of the common peroneal nerve across the lateral head of the gastrocnemius muscle (1993)

Abstract The fabella is an inconstant sesamoid bone located in the origin of the lateral head of the gastrocnemius muscle. The presence of a fabella has been associated with a number of pathologies including compression injury of the common peroneal nerve (CPN) as it crosses the lateral head of the gastrocnemius. This study was designed to determine the incidence of fabellae and the geometric relationship of the fabella to the CPN using anatomical dissection. In the 78 specimens examined, the incidence of fabellae was 27%, a figure near the high end of the previously reported range. To our knowledge, the geometric relationship of the fabella to the CPN has not previously been reported. Using measurements taken during dissection of fabellae, the zone of potential locations of the fabella overlapped 26.0% of the length of the CPN across the lateral head of the gastroenemius. © 1993 Wiley‐Liss, Inc.