gebhart/patrepeval huggingface dataset:
Posteromedial Approach to Proximal Tibia for Corticotomy in Callus Distractions (2006)

Corticotomy of the tibia using Ilizarov's anterolateral approach is used routinely for callus distraction. This method is associated with impaired callus formation and delayed healing because of marginal soft tissue covering and blood supply to the proximal tibia. We presumed a newly designed posteromedial approach would result in less callus defects and improved healing. In this prospective, randomized study, 31 patients had callus distraction using an anterolateral approach or the newly designed posteromedial approach. Callus formation was assessed radiographically and histologically. Callus defects were classified using serial radiographs. Biopsy specimens were taken from high-grade defect (Grades 3-4) zones to examine the osteogenic potential. Radiographic evaluation showed 13 callus defects; 12 occurred after the anterolateral approach and only one occurred after the posteromedial method. Although low-grade defects (Grades 1-2) healed spontaneously, biopsy specimens taken from Grades 3-4 defects revealed no osteogenic potential and requiring operative revision. Because of low soft tissue covering and impaired blood supply to the anterior tibia during surgical exposure for corticotomy, less callus formation occurred after the anterolateral approach compared with the posteromedial approach. We recommend the less invasive posteromedial approach to reduce callus defects and impaired healing in callus distraction of the proximal tibia.
Homéostasie chlorure et cotransporteurs cation-chlorure, douleur et nociception (2008)

En régulant les gradients anioniques, les cotransporteurs cation-chlorure, NKCC1 qui assure l’entrée d’ions chlorures et KCC2 qui en assure la sortie, modulent le système GABAergique et contrôlent les mécanismes de la douleur. Lors d’une inflammation ou d’un traumatisme, l’augmentation de l’activité de NKCC1 dans les neurones sensitifs et/ou la diminution de l’expression de KCC2 dans les neurones spinaux conduisent à la perte du tonus inhibiteur GABAergique et sont responsables de douleurs neuropathiques.
Fabrication of amperometric biosensors by entrapment of enzymes in functionalized polypyrrole films (1998)

Abstract The concept and potentialities of an original electrochemical procedure of enzyme immobilization are described. This two‐step method consists of the adsorption of an aqueous amphiphilic pyrrole monomer‐enzyme mixture on an electrode surface followed by the electropolymerization of the adsorbed monomers. This procedure is compared with the conventional electrochemical methods of biosensor construction. Several bienzyme electrodes devoted to the improvement of the biosensor selectivity or to the amplification of the biosensor sensitivity are described. In addition, examples of organic phase enzyme electrode and the electrical wiring of immobilized enzymes are presented.
Increased beta-actin expression in an invasive moloney sarcoma virus-transformed MDCK cell variant concentrates to the tips of multiple pseudopodia. (1998)

An invasive variant of Moloney sarcoma virus-transformed MDCK cells (MSV-MDCK-INV), which was isolated by the repeated selection of cells that successfully traversed a Matrigel-coated filter, exhibits increased motile ability and presents an elongated cell shape and numerous pseudopodia. Although stress fibers are present in both MDCK and MSV-MDCK cells, MSV-MDCK-INV cells contain no stress fibers and exhibit a dense concentration of actin at the tips of pseudopodia. Relative to both MDCK and MSV-MDCK cells, the MSV-MDCK-INV cells exhibit increased expression of beta-actin and redistribution of beta-actin to the tips of pseudopodia. These actin concentrations are enriched in both F- and G-actin and, thus, represent dynamic regions of actin cytoskeleton remodeling. The acquisition of invasive properties by epithelial transformants is, therefore, associated with the increased expression of beta-actin and its concentration in actin-rich domains, which may drive pseudopodial extension and facilitate tumor cell invasion.
The status of the QUIJOTE multi-frequency instrument (2012)

The QUIJOTE-CMB project has been described in previous publications. Here we present the current status of the QUIJOTE multi-frequency instrument (MFI) with five separate polarimeters (providing 5 independent sky pixels): two which operate at 10-14 GHz, two which operate at 16-20 GHz, and a central polarimeter at 30 GHz. The optical arrangement includes 5 conical corrugated feedhorns staring into a dual reflector crossed-draconian system, which provides optimal cross-polarization properties (designed to be &lt; &minus;35 dB) and symmetric beams. Each horn feeds a novel cryogenic on-axis rotating polar modulator which can rotate at a speed of up to 1 Hz. The science driver for this first instrument is the characterization of the galactic emission. The polarimeters use the polar modulator to derive linear polar parameters Q, U and I and switch out various systematics. The detection system provides optimum sensitivity through 2 correlated and 2 total power channels. The system is calibrated using bright polarized celestial sources and through a secondary calibration source and antenna. The acquisition system, telescope control and housekeeping are all linked through a real-time gigabit Ethernet network. All communication, power and helium gas are passed through a central rotary joint. The time stamp is synchronized to a GPS time signal. The acquisition software is based on PLCs written in Beckhoffs TwinCat and ethercat. The user interface is written in LABVIEW. The status of the QUIJOTE MFI will be presented including pre-commissioning results and laboratory testing.
Information systems: a construct of transformations (1995)

The paper provides a classification and typology of various configurations which make up the definition of an information system (IS). It is based on five basic building blocks: source, data, prediction, value, and action. Using those building blocks, it is possible to formally outline many configurations including data base management systems (DBMS), decision support systems (DSS), expert systems (ES), and autonomous intelligent machines (AIM). This paper formally defines the building blocks, functions and operators of systems that fall into the class of information system. The result is a cohesive construct of transformations for IS through which a variety of new configurations and systems are enumerated and explained. Such model, may make it possible to assemble an information system from "off the shelf" components rather than constructing it as done today.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
近年の学生女子ハンドボール競技におけるゲーム構成 ―2007年・2008年の学生女子上位チームの分析から― (2012)

This study was investigated that at examining the factor for winning with finding out the tendency of a student woman handball game in recent years ． Analysis was taken as the game of ８ teams of woman bests of the all Japan student handball championship in the 2008 fiscal year in the 2007 fiscal year． The result was as follows． ①In the student woman handball game of top class in recent years， the number of the goals was 26.6 points， the number of shots was 48.7 times， and the number of times of an attack was 67.9 times． In the number of times of an attack， it increased about 10 times per game from 15-year before， and speedy game deployment was developed． ② When it compared between a victory team and a loser team， the significant difference was seen in the number of shots （P< 0.05）， the number of the goals （P< 0.01）， the number of mistakes （P< 0.01）， the attack strike rate （P< 0.01）， the shot strike rate（ P< 0.01）， and the mistake rate（ P< 0.01）． ③ The strike rate of the set play was 28.1% in the loser team 42.1% in the victory team． Moreover， by the victory team， 23.2 %， in the loser team， it is 34.3 % and the significant difference（ P< 0.01） was seen about the rate of failure of the set play．
Induced Electrokinetic Transport in Micro−Nanofluidic Interconnect Devices (2007)

Hybrid micro-nanofluidic interconnect devices can be used to control analyte transfer from one microchannel to the other through a nanochannel under rest, injection, and recovery stages of operation by varying the applied potential bias. Using numerical simulations based on coupled transient Poisson-Nernst-Planck and Stokes equations, we examine the electrokinetic transport in a gateable device consisting of two 100 microm long, 1 microm wide negatively charged microchannels connected by a 1 microm long, 10 nm wide positively charged nanochannel under both positive and negative bias potentials. During injection, accumulation of ions is observed at the micro-nano interface region with the positive potential and depletion of ions is observed at the other micro-nano junction region. Net space charge in the depletion region gives rise to nonlinear electrokinetic transport during the recovery stage due to induced pressure, induced electroosmotic flow of the second kind, and complex flow circulations. Ionic currents are computed as a function of time for both positive and negative bias potentials for the three stages. Analytical expressions derived for ion current variation are in agreement with the simulated results. In the presence of multiple accumulation or depletion regions, we show that a hybrid micro-nano device can be designed to function as a logic gate.
An Automated Orthogonal Two-Dimensional Liquid Chromatograph (2003)

A simple approach to two-dimensional liquid chromatography has been developed by coupling columns of different selectivity using a 12-port, dual-position valve and a standard HPLC system. The valve at the junction of the two columns enables continuous, periodic sampling (injection) of the primary column eluent onto the secondary column. The separation in the primary dimension is comparable to conventional HPLC, whereas the secondary column separation is fast, lasting several seconds. The high-speed separation in the secondary dimension enables the primary column eluent to be sampled with fidelity onto the secondary column throughout the chromatographic run. One might expect a coupled column liquid chromatography system operating in reverse-phase mode to be strongly correlated and, hence, inefficient. However, by applying a solvent gradient in the primary dimension and by progressively incrementing the solvent strength in the secondary dimension (tuning), the inefficiency or cross correlation between the two dimensions is minimized. In a tuned two-dimensional system, the influence of primary column retention (usually hydrophobicity) is minimal on secondary column retention. This enables subtle differences in component interaction with the two stationary phases to dominate the secondary column retention. The peaks are randomly dispersed over a retention plane rather than along a diagonal, resulting in an orthogonal separation. The peak capacity is multiplicative, and each component has a unique pair of retention times, enabling positive identification. In addition, the location of the component provides two independent measures of molecular properties. The 2D-LC system was evaluated by analyzing a test mixture made of some aromatic amines and non-amines on different secondary columns (ODS-AQ/ODS monolith, ODS/amino, ODS/cyano). The relative location of sample components in the two-dimensional plane varied significantly with change in secondary column. Among the secondary columns, the amino and cyano columns offered the most complementary separation, with the retention order of several components reversed in the secondary dimension. The theoretical peak capacity of the 2D-LC system was around 450 for a separation lasting 30 min. A 2D-LC system involving amino and cyano columns resulted in a high-speed separation of the test mixture, with most of the chemical components resolved within a few minutes.
Nanomechanical control of the activity of enzymes immobilized on single-domain magnetic nanoparticles (2014)

Analytical and numerical methods are used to analyze the main regularities of deformation of biologically active molecules caused by the nonthermal effect of low-frequency magnetic field on single-domain magnetic nanoparticles to the surfaces of which the macromolecules are chemically bound.
Relative paradigms between autoantibodies in lupus and autoantibodies in cancer (2003)

Autoantibodies which are reactive with intracellular antigens have been studied extensively in autoimmune rheumatic diseases such as systemic lupus erythematosus (lupus), Sjogren's syndrome, scleroderma, dermatomyositis/polymyositis, and other related diseases [1]. Autoantibodies are being recognized with increasing frequency in other illnesses including type I diabetes [2], the paraneoplastic neurological disease syndromes [3,4], liver diseases [5], bullous skin diseases, inflammatory bowel diseases, thyroid and other endocrinopathies, haematopoietic disorders and many others [6]. Autoantibody to p53 was detected in breast cancer [7] but for a time the main interest was in T cell-mediated autoimmunity [8], until it became evident that humoral immunity was also a prominent response in many different types of cancer [9–11].

In this paper, we will review and discuss the special features of spontaneously occurring autoantibodies and in the case of cancer, how some patients’ immune systems appear to be sensing aberrant cellular mechanisms related to tumorigenesis and reporting these events in the form of the contemporaneous appearance of neo-antibodies. There are some similarities between autoantibodies in lupus (and other autoimmune diseases) and autoantibodies in cancer and there are some differences, but important insights into aetiology, pathogenesis and therapeutic strategies could be gained by careful analysis of the deeper implications of autoimmune responses in both lupus and cancer.
Acceleration of Capsule Formation around Silicone Implants by Infection in a Guinea Pig Model (1984)

Kossovsky, Nir M.D; Heggers, John P. Ph.D; Parsons, Robert W. M.D; Robson, Martin C. M.D.; Anderson, James M. Ph.D., M.D.; Anderson, James M. Ph.D., M.D. Author Information
Implantes dentales de superficie porosa en el maxilar superior parcialmente edéntulo: detección de movilidad subclínica (2002)

Se insertaron 151 implantes cortos de superficie porosa en los maxilares superiores parcialmente edentulos de 50 pacientes. Se registraron los valores de Periotest (VPT) al comenzar y despues de 6 meses, 1 ano y 2 anos. Para ello se extrajeron las protesis y se fijo y apreto (20 Ncm de fuerza) un pilar estandar a cada implante. El analisis de los datos demostro la existencia de una relacion significativa entre el tiempo de servicio y el VPT y entre el diametro de los implantes (3, 5, 4, 1 o 5, 0 mm) y el VPT. No se observo ninguna correlacion entre el VPT y la longitud de los implantes. Los valores de Periotest fueron mas favorables en la region posterior del maxilar superior que en la region anterior, y tambien fueron mejores en los implantes sin ferulizar que en los ferulizados.
Integrating Theory and Policy: Global Implications of the War in Iraq (2004)

War is too important to be left to the generals or to the politicians. In a dynamic world increasing in complexity at a geometric rate, it is no longer prudent to assume that any one professional class alone, no matter their dedication or training, can be the objective repository for all knowledge, analysis, synthesis, and estimative power on how to conduct war. Just as the U.S. Constitution was founded on the concept of separate institutions sharing power, today it is equally critical that multiple sources of information and analysis be assembled and tested prior to decisions that could fundamentally alter world politics. At present the United States is unnecessarily handicapping its national security capabilities by often ignoring highly powerful tools developed by the academic community. Partly this is the result of ignorance of, or distain for, intellectual contributions. Partly it is the result of an academic community failing to communicate...
Temperature Effects on Nozzle Guide Vane Deposition in a New Turbine Cascade Rig (2016)

A new turbine cascade has been constructed that is designed to investigate the performance of actual nozzle guide vane hardware at temperatures representative of modern gas turbine engines. The facility is designed to investigate internal and external deposition, analyze the effectiveness of new cooling techniques, characterize material systems such as metal substrates or coatings, and assess the aerodynamic performance of a vane. The results presented here are the first results obtained in this new facility. External deposition on cooled CFM56 nozzle guide vanes has been explored at inlet temperatures of 1090° C, 1265° C, and 1350° C. Results at 1090° C have been compared to similar results in a previous facility. External deposition tests at temperatures greater than 1100° C on actual turbine hardware have not been reported publicly prior to this paper. These results show that deposition is concentrated at the stagnation line at all three inlet conditions. The amount of deposition on the vane pressure surface increased with increasing inlet temperatures.
Influence des caracteristiques visuelles de la chaussee sur l'anticipation de la collision et l'estimation de sa propre vitesse lors de l'arrivee a un carrefour (2001)

L'analyse du mouvement d'un vehicule par le conducteur en deplacement implique le traitement d'informations visuelles globales issues de l'environnement routier, et d'informations visuelles locales creees par le mouvement de l'autre vehicule. Le role respectif et les interactions de ces deux types d'informations, dans une tâche complexe telle que la conduite automobile, reste une question d'actualite. Ici, deux experimentations en simulation faisaient varier les memes parametres environnementaux lors de l'approche d'une intersection a laquelle se presentait un vehicule. La tâche des sujets consistait a anticiper une situation de collision avec ce vehicule ou a estimer leur propre vitesse de deplacement. Les performances temoignent d'une influence des caracteristiques visuelles globales de la chaussee dans les deux experiences. Toutefois, si le flux optique global produit par la presence de texture ou de marquage sur la chaussee semble amplifier la sensation de vection ressentie par les sujets, cet effet est module par les caracteristiques de la tâche. Il est relativise lorsque celle ci consiste a anticiper le mouvement de l'autre vehicule.
Isotactic poly(p-fluorostyrene): Conformation and molecular packing analysis (1974)

Abstract The chain conformation and molecular packing of isotactic poly(p-fluorostyrene) have been examined using calculations made with semiempirical potential energy functions. Isolated chain conformational energies indicate no difference in conformation for the fluoropolymer from the conformation for isotactic polystyrene. The energy for packing poly(p-fluorostyrene) chains into a crystalline array as 31 or 41 helices was also compared with the energies for packing polystyrene in both of these helical forms. While not being the lowest energy mode of packing for poly(p-fluorostyrene), the packing of 41-helices does yield a local energy minimum. Such packing of 41 helical polystrene chains is considerably less energetically feasible. The results indicate the causes for the experimentally observed difference in the crystalline conformations of the two isotactic polymers as being due to intermolecular influences.
Characterization of dermal sensitization potential for industrial or agricultural chemicals with EpiSensA (2020)

The regulatory community is transitioning to the use of nonanimal methods for dermal sensitization assessments; however, some in vitro assays have limitations in their domain of applicability depending on the properties of chemicals being tested. This study explored the utility of epidermal sensitization assay (EpiSensA) to evaluate the sensitization potential of complex and/or "difficult to test" chemicals. Assay performance was evaluated by testing a set of 20 test chemicals including 10 methacrylate esters, 5 silicone-based compounds, 3 crop protection formulations, and 2 surfactant mixtures; each had prior in vivo data plus some in silico and in vitro data. Using the weight of evidence (WoE) assessments by REACH Lead Registrants, 14 of these chemicals were sensitizers and, six were nonsensitizers based on in vivo studies (local lymph node assay [LLNA] and/or guinea pig studies). The EpiSensA correctly predicted 16/20 materials with three test materials as false positive and one silane as false negative. This silane, classified as weak sensitizer via LLNA, also gave a "false negative" result in the KeratinoSens™ assay. Overall, consistent with prior evaluations, the EpiSensA demonstrated an accuracy level of 80% relative to available in vivo WoE assessments. In addition, potency classification based on the concentration showing positive marker gene expression of EpiSensA was performed. The EpiSensA correctly predicted the potency for all seven sensitizing methacrylates classified as weak potency via LLNA (EC3 ≥ 10%). In summary, EpiSensA could identify dermal sensitization potential of these test substances and mixtures, and continues to show promise as an in vitro alternative method for dermal sensitization.
The Clover Leaf Weevil Parasite Biolysia tristis in the Midwest (1966)

Biolysia tristis (Gravenhorst), a primary larval parasite of the clover leaf weevil, Hypera punctala (F.), was found in 27 counties throughout the southern half of Illinois, and in 3 counties in central and 1 in western Missouri in 1965. These records constitute the first detection of this introduced parasite in the Midwest. The incidence of parasitization in several areas of Illinois and Missouri is presented for the winter and spring of 1965. During this period B. tristis appeared to be a much more important factor in the reduction of H. punctala larval populations than the fungus Entomopthora sphaerosperma Fres.
Specific reduction of E prostaglandins to F.alpha. prostaglandins and prostaglandin E2 to prostaglandin E1 (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpecific reduction of E prostaglandins to F.alpha. prostaglandins and prostaglandin E2 to prostaglandin E1E. J. Corey and Ravi K. VarmaCite this: J. Am. Chem. Soc. 1971, 93, 26, 7319–7320Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/ja00755a036https://doi.org/10.1021/ja00755a036research-articleACS PublicationsRequest reuse permissionsArticle Views599Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts