gebhart/patrepeval huggingface dataset:
Obesity—time to wake up (2006)

<h3>ABSTRACT</h3> Intracellular trafficking pathways control residency and bioactivity of integral membrane proteins at the cell surface. Upon internalisation, surface cargo proteins can be delivered back to the plasma membrane via endosomal recycling pathways. Recycling is thought to be controlled at the metabolic and transcriptional level, but such mechanisms are not fully understood. In yeast, recycling of surface proteins can be triggered by cargo deubiquitination and a series of molecular factors have been implicated in this trafficking. In this study, we follow up on the observation that many subunits of the Rpd3 lysine deacetylase complex are required for recycling. We validate ten Rpd3-complex subunits in recycling using two distinct assays and developed tools to quantify both. Fluorescently labelled Rpd3 localises to the nucleus and complements recycling defects, which we hypothesised were mediated by modulated expression of Rpd3 target gene(s). Bioinformatics implicated 32 candidates that function downstream of Rpd3, which were over-expressed and assessed for capacity to suppress recycling defects of <i>rpd3Δ</i> cells. This effort yielded 3 hits: Sit4, Dit1 and Ldb7, which were validated with a lipid dye recycling assay. Additionally, the essential phosphatidylinositol-4-kinase Pik1 was shown to have a role in recycling. We propose recycling is governed by Rpd3 at the transcriptional level via multiple downstream target genes.
Permanent Ostomy After Ileoanal Pouch Failure (2011)

Although technically more challenging, pouch excision, rather than pouch left in situ, is the preferable option for patients who develop pouch failure and are not candidates for restoration of intestinal continuity. Because pouch left in situ was not associated with neoplasia, this option is a reasonable intermediate or long-term alternative when pouch excision is not feasible or advisable.
Use of an adsorbent and antioxidants to reduce the effects of leached phenolics in in vitro plantlet regeneration of faba bean (2008)

Development of a reliable in vitro regeneration protocol is necessary to facilitate genetic transformation of faba bean. However, leaching of phenolics from the explants of most genotypes of faba bean to the culture medium causes browning, and eventually kills the explants, hindering in vitro regeneration. This study is aimed to minimize the effect of phenolics and to identify the most suitable types of explants for in vitro regeneration. We pre-treated faba bean seeds in polyvinylpyrrolidone (PVP), then cultured different types of explants on tissue culture media supplemented with an adsorbent (activated charcoal) and antioxidants (ascorbic acid, cysteine and silver nitrate). Our results showed that treating the over night soaked seed (after removing the seed coat) with PVP solution (1000 mg/l) for 1 h, followed by culturing in Murashige and Skoog medium (MS medium) with 3% (w/v) sucrose, 0.8% (w/v) agar, 2 mg/l 6-benzylaminopurine and 2 mg/l thidiazuron, supplemented with ascorbic acid (1 mg/l) or activated charcoal (10 g/l), greatly reduced lethal browning in explants and improved shoot regeneration. The shoots rooted on half-strength MS medium supplemented with 0.5 mg/l -naphthaleneacetic acid. The cotyledonary node is the most suitable type of explant for regeneration. Regenerated plantlets were successfully established in pots and set seeds in the green house.
Chemistry of Dicyandiamide. V. Structures of Guanazo- and Pyro-Guanazoles, and Reaction of Dicyandiamide with 3-Amino-5-Substituted-1,2,4, 4H-Triazoles (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleChemistry of Dicyandiamide. V. Structures of Guanazo- and Pyro-Guanazoles, and Reaction of Dicyandiamide with 3-Amino-5-Substituted-1,2,4, 4H-TriazolesD. W. Kaiser, G. A. Peters, and V. P. WystrachCite this: J. Org. Chem. 1953, 18, 11, 1610–1615Publication Date (Print):November 1, 1953Publication History Published online1 May 2002Published inissue 1 November 1953https://pubs.acs.org/doi/10.1021/jo50017a024https://doi.org/10.1021/jo50017a024research-articleACS PublicationsRequest reuse permissionsArticle Views492Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Text mining and software engineering: an integrated source code and document analysis approach (2008)

Documents written in natural languages constitute a major part of the artefacts produced during the software engineering life cycle. Especially during software maintenance or reverse engineering, semantic information conveyed in these documents can provide important knowledge for the software engineer. A text mining system capable of populating a software ontology with information detected in documents is presented. A particular novelty is the integration of results from automated source code analysis into a natural language processing pipeline, allowing to cross-link software artefacts represented in code and natural language on a semantic level.
2-Substituted 1,2,3,4-Tetrahydroquinolines from Quinoline (1989)

The addition of various organometallic reagents to quinoline occurred solely at the 2-position of the heteroaromatic ring. The resultant 2-substituted 1,2-dihydroquinolines were then easily reduced with sodium in ethanol to the 1,2,3,4-tetrahydro species. The overall transformation of quinoline to 2-substituted 1,2,3,4-tetrahydroquinolines was found to be favorable to the previous literature conditions, which required an intermediate oxidative step. The yields for the last step ranged from 42-98% but were generally greater than 80%.
Lymphocytes (1990)

The surgical sciences have made significant advances in our understanding of the immunological alterations associated with transplantation, trauma, oncology, and wound healing. Immune surveillance, regulation, and effector cell functions have been demonstrated to play integral roles in these disease states. Immune manipulation may be an effective therapeutic modality with even greater potential for the future. This study highlights recent progress in our understanding of immunomodulatory interventions that exploit manipulations in lymphocyte function in transplantation.
Practical Results on the Development of a Control Moment Gyro Based Attitude Control System for Agile Small Satellites (2002)

In this paper a new practical Attitude Control System is proposed, based on Control Moment Gyroscopes (CMG). These actuators can provide unique torque, angular momentum and slew rate capabilities to small satellites without any increase in power, mass or volume. This will help small satellites become more agile and maneuverable. Agility considerably increases the operational envelope and efficiency of spacecraft and substantially increases the return of earth and science mission data. The paper focuses on the practical work on developing the hardware for a low cost, miniature CMG for agile small satellites. Experimental results indicate the potential benefits of using CMGs. Specifically, a cluster of four Single Gimbal CMGs (SGCMG) is used to practically demonstrate full 3-axis control for a microsatellite class spacecraft. Additionally, results are presented on the development of a larger SGCMG proposed as an experimental payload for future enhanced microsatellite missions.
An algorithm of node collection in Distributed File System based on mathematical expectation (2010)

For conquering the effect of data transmission in user access to the randomness between system and user in distributed virtual environment, in this paper algorithm of node collection in DFS (Distributed File System) based on expectation is presented. We present the mathematical model and calculation steps too. And in this paper we propose not only the application of a polynomial function fitting the user with the speed sets on the network node cluster but also the tactics of calculation the max expectation from the function Fitting. Simulations show that we can find the best node in every area and different sessions from this algorithm and tactic.
Control of sporulation-specific cell division in Streptomyces coelicolor (2007)

During developmental cell division in sporulation-committed aerial hyphae of streptomycetes, up to a hundred septa are simultaneously produced, in close harmony with synchromous chromosome condensation and segregation. Several unique protein families are involved in the control of this process, including that of the SsgA-like proteins (SALPs). While SsgA and SsgB are essential for sporulation-specific cell division in S. coelicolor, SsgC-G are responsible for correct DNA segregation/condensation, spore wall synthesis, autolytic spore separation, or exact septum localisation. The SALPs are a novel protein family that acts through timing and localisation of the activity of penicillin-binding proteins and autolysins, thus controlling important steps during the initiation and the completion of sporulation. The formation of septa is initiated by the formation of a ring of the tubulin-like protein FtsZ (the Z-ring), functioning as a scaffold for the construction of septa. Subsequently, other cell division proteins are recruited to the Z-ring, forming the divisome. In S. coelicolor, the cell division proteins FtsE and FtsX participate during autolytic spore separation, and most likely function by re-importing peptidoglycan subunits for recycling. The cytoskeletal protein MreB is involved in cell shape determination and chromosome segregation in many rod-shaped bacteria. In S. coelicolor, the actin-like proteins MreB and Mbl are not essential for vegetative growth but exert their function in the formation of environmentally stable spores, thereby primarily influencing the assembly of the spore wall.
Physiological Functions of Cyclic Electron Transport Around Photosystem I in Sustaining Photosynthesis and Plant Growth (2016)

The light reactions in photosynthesis drive both linear and cyclic electron transport around photosystem I (PSI). Linear electron transport generates both ATP and NADPH, whereas PSI cyclic electron transport produces ATP without producing NADPH. PSI cyclic electron transport is thought to be essential for balancing the ATP/NADPH production ratio and for protecting both photosystems from damage caused by stromal overreduction. Two distinct pathways of cyclic electron transport have been proposed in angiosperms: a major pathway that depends on the PROTON GRADIENT REGULATION 5 (PGR5) and PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE 1 (PGRL1) proteins, which are the target site of antimycin A, and a minor pathway mediated by the chloroplast NADH dehydrogenase-like (NDH) complex. Recently, the regulation of PSI cyclic electron transport has been recognized as essential for photosynthesis and plant growth. In this review, we summarize the possible functions and importance of the two pathways of PSI cyclic electron transport.
Compliance and Effectiveness of 1 Year's Home Telemonitoring. The Report of a Pilot Study of Patients with Chronic Heart Failure (2001)

Home telemonitoring is an acceptable reliable intervention. Baseline rates for compliance with self-monitoring are set out in this study. Benefit in terms of compliance with medication and self-monitoring is still seen after 1 year. Video consulting over ordinary telephone lines did not show sustained benefit, and was not complied with.
A Novel Method of Feature Extraction and Classification for OPCCR (2012)

In optical printed Chinese character recognition (OPCCR), support vector machine (SVM) is thought to be a good classifier. However, the recognition rate of SVM depends on the features extracted and the time consumption of it is large. For this reason, we propose statistic features (SF) and local nearest neighbor SVM (LNN-SVM) to promote the recognition rate and to reduce the computational time of SVM. Experiments have been done and the results showed that SF and LNN-SVM can promote the recognition rate and reduce the computational time in OPCCR.
Some buffet response characteristics of a twin-vertical-tail configuration (1990)

A rigid, 1/6 size, full span model of an F-18 airplane was fitted with flexible vertical tails of two different levels of stiffness that were buffet tested in the Langley Transonic Dynamics Tunnel. Vertical tail buffet response results that were obtained over the range of angles of attack from -10 to 40 degs, and over the range of Mach numbers from 0.30 to 0.95 are presented. These results indicate the following: (1) the response occurs in the first bending mode; (2) the response increases with increasing dynamic pressure, but changes in response are not linearly proportional to the changes in dynamic pressure; (3) the response is larger at M = 0.30 than it is at the higher Mach numbers; (4) the maximum intensity of the buffeting is described as heavy to severe using an assessment criteria proposed by another investigator; and (5) the data at different dynamic pressures and for the different tails correlate reasonably well using the buffet excitation parameter derived from the dynamic analysis of buffeting.
The Role of the General Practitioner in the Care of Mentally Disturbed Subjects in the General Population — Results of the Upper Bavarian Study (1989)

The role of the general practitioner in the care of mentally disturbed non-institutionalised persons aged 20 years and older was examined. Data were based on the representative community sample of the Upper Bavarian Field Study with a sample size of 1495 interviewees--aged 20 years and older. The 5-year prevalence of mental illness according to the definition used was 32.8%. 38.5% of all persons, identified as cases, consulted their general practitioner because of psychiatric or emotional problems. Females and the elderly were most likely to have received treatment by their general practitioner. The majority of treated persons were neurotic and psychosomatic patients. The general practitioner provided care for more psychiatric patients than the psychiatrist and for 25% of all "cases", without additional psychiatric consultation.
Clinical Evaluation of the Prophy‐Jet<sup>®</sup> as an Instrument for Routine Removal of Tooth Stain and Plaque (1984)

The Prophy-Jet was evaluated for its effectiveness in removing plaque and stain from teeth and on its effects on the marginal gingiva. Using a randomized split-mouth design, half the mouth was treated with the Prophy-Jet and the contralateral side with a rubber cup and prophylaxis paste. The results indicated that the Prophy-Jet removes tooth plaque and stain as well as the rubber cup and prophylaxis paste method, and does so in less time. It was also found that there was some immediate soft tissue trauma following both treatment modalities, with a mean Trauma Index score of 0.23 not equal to 0.16 for the rubber cup and prophylaxis paste and 0.75 not equal to 0.37 for the Prophy-Jet. Within 6 days, the trauma index scores were not significantly different. Similar results were found for marginal gingival redness and bleeding on probing. The Prophy-Jet is an excellent alternative instrument for removal of tooth stain and dental plaque.
Recombinant Erythropoietin and Analogues (2004)

Erythropoietin (EPO) increases the number of circulating erythrocytes and thus muscle oxygenation. The availability of the recombinant protein (rEPO) has increased the risk of its illegal use in sports, its detection being a difficult challenge. Five different hematopoietic parameters were initially chosen as indirect markers of rEPO abuse: concentration of serum EPO, concentration of serum-soluble transferrin receptors (sTFr), hematocrit, percentage of reticulocytes, and percentage of macrocytes. New models considering only hemoglobin, serum EPO concentration, and percentage of reticulocytes are simpler and seem to be more sensitive when low doses of rEPO are used. A more direct method of urine analysis (isoelectrofocusing, double blotting, and chemiluminescent detection) based on the charge differences between rEPO and endogenous EPO, related to their carbohydrate composition, provides proof of rEPO use. Furthermore, this approach permits the detection of darbepoetin, a direct analogue of EPO also known as NESP ("new erythropoiesis stimulating protein"). Recently a protein conjugate, "synthetic erythropoiesis protein" (SEP), containing precision-length, monodisperse, negatively charged polymers instead of oligosaccharides has been synthesized. Finally, EPO-mimetics are molecules capable of acting as EPO in dimerizing the EPO receptor. Two kinds of EPO-mimetics have been described: peptides and nonpeptides. The enhancement of oxygen availability to muscles by rEPO, analogues, and mimetics constitutes one of the main challenges to doping control. Major steps have already been developed for detection ofrEPO and some analogues. In the near future, the transfection to an athlete's body of genes that code for erythropoietin might be an emerging doping issue, and sports authorities have incorporated "gene doping" among the prohibited practices.
Current progress in high cell density yeast bioprocesses for bioethanol production (2015)

Abstract High capital costs and low reaction rates are major challenges for establishment of fermentation‐based production systems in the bioeconomy. Using high cell density cultures is an efficient way to increase the volumetric productivity of fermentation processes, thereby enabling faster and more robust processes and use of smaller reactors. In this review, we summarize recent progress in the application of high cell density yeast bioprocesses for first and second generation bioethanol production. High biomass concentrations obtained by retention of yeast cells in the reactor enables easier cell reuse, simplified product recovery and higher dilution rates in continuous processes. High local cell density cultures, in the form of encapsulated or strongly flocculating yeast, furthermore obtain increased tolerance to convertible fermentation inhibitors and utilize glucose and other sugars simultaneously, thereby overcoming two additional hurdles for second generation bioethanol production. These effects are caused by local concentration gradients due to diffusion limitations and conversion of inhibitors and sugars by the cells, which lead to low local concentrations of inhibitors and glucose. Quorum sensing may also contribute to the increased stress tolerance. Recent developments indicate that high cell density methodology, with emphasis on high local cell density, offers significant advantages for sustainable second generation bioethanol production.
Pregabalin: A new agent for the treatment of neuropathic pain (2005)

Pregabalin (Lyrica, Pfizer) is a GABA analog with similar structure and actions to gabapentin. It has antiepileptic, analgesic and anxiolytic activity. Pregabalin is indicated for the management of neuropathic pain associated with diabetic neuropathy and post-herpetic neuralgia. Peak plasma levels occur approximately 1 hour after oral doses and oral bioavailability is about 90%. Based on AUC data, food does not significantly affect the extent of absorption. Pregabalin is not protein-bound and exhibits a plasma half-life of about 6 hours, which is not dose-dependent. Hepatic metabolism is negligible, and most of the oral dose (95%) appears unchanged in the urine. Pregabalin is a safe and well-tolerated new treatment for neuropathic pain. Furthermore, pregabalin has proven efficacy in adjunctive therapy of refractory partial seizures and in the treatment of acute pain, generalized anxiety disorder and social phobia.
ChemInform Abstract: A SIMPLE SYNTHESIS OF NATURAL PRODUCTS WITH FURAN‐2(5H)‐ONE STRUCTURE (1983)

Abstract Ausgehend von den Aldehyden (I) werden mit dem Furan (II) die Butenoljde (III) dargestellt.
[Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study]. (1993)

The efficacy of a Vitex agnus castus preparation (Strotan capsules) was investigated in a randomized double blind study vs. placebo. This clinical study involved 52 women with luteal phase defects due to latent hyperprolactinaemia. The daily dose was one capsule (20 mg) Vitex agnus castus preparation and placebo, respectively. Aim of the study was to prove whether the elevated pituitary prolactin reserve can be reduced and deficits in luteal phase length and luteal phase progesterone synthesis be normalized. Blood for hormonal analysis was taken at days 5-8 and day 20 of the menstrual cycle before and after three month of therapy. Latent hyperprolactinaemia was analysed by monitoring the prolactin release 15 and 30 min after i.v. injection of 200 micrograms TRH. 37 complete case reports (placebo: n = 20, verum: n = 17) after 3 month of therapy were statistically evaluated. The prolactin release was reduced after 3 months, shortened luteal phases were normalised and deficits in the luteal progesterone synthesis were eliminated. These changes were significant and occurred only in the verum group. All other hormonal parameters did not change with the exception of 17 beta-estradiol which rouse up in the luteal phase in patients receiving verum. Side effects were not seen, two women treated with the Vitex agnus castus preparation got pregnant. The tested preparation is thought to be an efficient medication in the treatment of luteal phase defects due to latent hyperprolactinaemia.
A Trust Model for Ubiquitous Systems based on Vectors of Trust Values (2006)

Ubiquitous computing foresees a massively networked world supporting a population of diverse but cooperating mobile devices where trust relationships between entities are uncertain. Though there have been lots of effort focusing on trust for ubiquitous systems, they did not attach enough importance to uncertainty in their model. On the other hand, most of the works draw a general picture without a detailed computational model. In this paper, we present a trust model based on the vectors of trust values of different entities. The evaluation of trust depends upon the recommendation of peer entities common to the interacting entities. These recommendations are weighted according to the number and time of past interactions. Furthermore we present a method of handling false recommendations without introducing significant computational burden. The model can calculate trust between two entities in situations both in which there is past experience among the interacting entities and in which the two entities are communicating for the first time. Several tuning parameters are suggested which can be adjusted to meet the security requirement of a ubiquitous system.
CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model (2016)

Intrathecal administration of the CD200R1 agonist CD200Fc induces very rapid suppression of neuroinflammatory reactions associated with glial activation and neuropathic pain development. This may constitute a promising and novel therapeutic approach for the treatment of neuropathic pain.