gebhart/patrepeval huggingface dataset:
Induction of Host Gene Expression following Infection of Chicken Embryo Fibroblasts with Oncogenic Marek's Disease Virus (2001)

Microarrays containing 1,126 nonredundant cDNAs selected from a chicken activated T-cell expressed sequence tag database (http://chickest.udel.edu) were used to examine changes in host cell gene expression that accompany infection of chicken embryo fibroblasts (CEF) with Marek's disease virus (MDV). Host genes that were reproducibly induced by infection of CEF with the oncogenic RB1B strain of MDV included macrophage inflammatory protein, interferon response factor 1, interferon-inducible protein, quiescence-specific protein, thymic shared antigen 1, major histocompatibility complex (MHC) class I, MHC class II, beta(2)-microglobulin, clusterin, interleukin-13 receptor alpha chain, ovotransferrin, a serine/threonine kinase, and avian leukosis virus subgroup J glycoprotein.
Induction of interleukin (IL)-1α and β gene expression in human keratinocytes exposed to repetitive strain: Their role in strain-induced keratinocyte proliferation and morphological change (1998)

Recent studies in our laboratory have demonstrated that mechanical strain alters many facets of keratinocyte biology including proliferation, protein synthesis, and morphology. IL-1 is known to play an important role in the autocrine regulation of these basic cellular properties under basal and stimulated conditions. However, it is not known whether IL-1 plays a role in strain-induced alteration of keratinocyte biology. Thus, the objective of this study was to test the hypothesis that cyclic strain stimulates IL-1 expression and that strain-induced changes in keratinocyte function is regulated by IL-1. To test this hypothesis, we examined the effect of cyclic strain (10% average deformation) on keratinocyte IL-1 gene expression and the effect of neutralizing antibodies of IL-1 alpha and IL-1 beta on strain-induced changes in keratinocyte proliferation, morphology, and orientation. Northern blot analyses demonstrated that steady state levels of IL-1 alpha and beta mRNA were elevated by 4 h, peaked at 1 2 h of cyclic strain (IL-1 alpha, 304+/-14.2%; IL-1 beta, 212+/-5.6% increase vs. static controls) and decreased gradually by 24 h. IL-1 antibodies (IL-1 alpha, 0.01 microg/ml; IL-1 beta, 0.01 microg/ml) significantly blocked strain-induced keratinocyte proliferation as well as the basal rate of proliferation. In contrast, IL-1 antibodies (IL-1 alpha, 0.01 microg/ml; IL-1 beta, 0.1 microg/ml) had no effect on strain-induced morphological changes such as elongation and alignment. We conclude that mechanical strain induces IL-1 mRNA expression in keratinocytes. The role of IL-1 in mediating strain-induced changes in keratinocyte biology remains to be determined but appears to be independent of morphological changes.
Non-dissociative C<sub>2</sub><sup>-</sup>and C<sub>2</sub>H<sup>-</sup>ion formation by double electron transfer in one collision (1990)

Positive ions produced from C2H2 by electron impact were collided with Cs, K and Na vapours in the keV energy range. Negative ions formed by two electron transfers were mass-analysed. C-, CH-, C2- and C2H- ions formed by dissociative and/or nondissociative processes were observed. The dependences of each ion on target density were measured. Formations of nondissociative C2- ions from C2+ ions and C2H- ions from C2H+ ions were determined to be double electron transfers in one collision from the density dependence for the Cs target. The cross sections of nondissociative C- and CH- ion formations were much less than those of C2- and C2H- ion formations. The order of cross sections for nondissociative C2- and C2H- ions in the condition of a Cs target at the collision energy of 3.0 keV was estimated to be 10-18 cm2. Nondissociative peaks of C2- and C2H- ions which were detected with a Cs target were not, however, observed with either the K or Na targets. The double electron transfer cross sections are discussed in relation to the endothermicity.
Fecal Microbiota Transplantation: Restoring the Injured Microbiome after Allogeneic Hematopoietic Cell Transplantation (2018)

Disruption of the intestinal microbiome early after allogeneic hematopoietic cell transplantation (allo-HCT) has been linked to adverse outcomes in transplant recipients. To date, whether microbiome-directed interventions will be able to impact important clinical endpoints remains unknown. Fecal microbiota transplantation (FMT) is a compelling intervention to restore healthy diversity to the intestinal microenvironment after allo-HCT, but currently has no established role in transplant recipients. In this review, we examine the use of FMT as treatment for Clostridium difficile infection and acute graft-versus-host disease, and also as a restorative intervention early after allo-HCT. Ongoing and planned studies will help determine the ultimate role of FMT in allo-HCT recipients.
GROPG: A graphical on-phone debugger (2013)

Debugging mobile phone applications is hard, as current debugging techniques either require multiple computing devices or do not support graphical debugging. To address this problem we present GROPG, the first graphical on-phone debugger. We implement GROPG for Android and perform a preliminary evaluation on third-party applications. Our experiments suggest that GROPG can lower the overall debugging time of a comparable text-based on-phone debugger by up to 2/3.
The contribution of salvage surgery to the management of childhood osteosarcoma. (1991)

Between January 1970 and December 1988, 174 consecutive patients under the age of 20 years with curatively resected primary osteosarcoma were treated at our institute; 72 in the years of 1970 to 1981 and 102 in the years 1982 to 1988. In the latter period, adjuvant chemotherapy was replaced by neoadjuvant programs, and new criteria were adopted for the management of lung metastases, consisting in early bilateral surgical staging and lung resection through median sternotomy for all patients with purely intrathoracic relapse. Follow-up was updated in December 1989. During the last period, the overall 5-year survival improved significantly from 35% to 58% (P less than .001). The disease-free survival rose from 38% to 45% at 5 years, with median values of 15 months versus 33 months, while the frequency of isolated lung metastases dropped from 58% to the actuarial 48%. The proportion of patients who underwent complete resections of their pulmonary metastases rose from 17% (seven of 42) to 55% (27 of 49), without operative mortality. Due to such a high proportion of patients eligible for salvage surgery, the overall survival from detection of lung metastases improved from 0% to 28% at 5 years (P less than .001). Contralateral occult metastases were resected in three of 15 subjects with monolateral clinical lesions, and five patients underwent subsequent lung resections. These data indicate that systematic bilateral pulmonary resection plays an important role in improving the final cure rate of childhood osteosarcoma, beyond the benefit resulting from neoadjuvant chemotherapy.
A cryptography based privacy preserving solution to mine cloud data (2010)

Due to increased adoption of cloud computing, there is a growing need of addressing the data privacy during mining. On the other hand, knowledge sharing is a key to survive many business organizations. Several attempts have been made to mine the data in distributed environment however, maintaining the privacy while mining the data over cloud is a challenging task. In this paper, we present an efficient and practical cryptographic based scheme that preserves privacy and mine the cloud data which is distributed in nature. In order to address the classification task, our approach uses k-NN classifier. We extend the Jaccard measure to find the similarity between two encrypted and distributed records by conducting an equality test. In addition, our approach accelerates mining by finding nearest neighbours at local and then at global level. The proposed approach avoids transmitting the original data and sharing of the key that is required in traditional crypto based privacy preserving data mining solutions.
ChemInform Abstract: Synthesis of 1,3‐Diketones by Reaction of α‐Haloketones with Acyl Cyanides Promoted by Samarium Diiodide. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fair Numbers of Peremptory Challenges in Jury Trials (1979)

Abstract We propose a model for determining the appropriate number of peremptory challenges for each party to a jury trial to ensure fairness. We suppose that all jurors not removed for cause may be thought of as in one of three categories: biased against the prosecution/plaintiff, biased against the defense, and fair. We propose that a fair number of peremptory challenges for a side is that number sufficient to challenge all jurors biased against it, with a certain probability. Given estimates for the various parameters in the model, an exact algorithm, and an approximation are proposed and illustrated.
Geometric formulation, classification and methods for power electronic systems (2002)

A systematic approach to the formulation of continuous-time dynamic equations for switching power converters is presented. A new modeling formalism for semiconductor switches is developed as part of this approach. The general structure of the equations is investigated, and, based on a geometric interpretation of the equations, a classification scheme is proposed. Nonlinear methods for analysis and control appropriate to each class are examined. A comparison of current mode and voltage mode DC-DC power converter control is presented as an example.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mid-IR distributed feedback interband cascade lasers (2004)

We report mid-IR distributed feedback interband cascade lasers operating in continuous-wave mode at temperatures up to 175 K with single longitudinal mode emission and side mode suppression ratio greater than 30 dB.
Protease Trafficking in Two Primitive Eukaryotes Is Mediated by a Prodomain Protein Motif (1999)

Trypanosome protozoa, an early lineage of eukaryotic cells, have proteases homologous to mammalian lysosomal cathepsins, but the precursor proteins lack mannose 6-phosphate. Utilizing green fluorescent protein as a reporter, we demonstrate that the carbohydrate-free prodomain of a trypanosome cathepsin L is necessary and sufficient for directing green fluorescent protein to the lysosome/endosome compartment. A proper prodomain/catalytic domain processing site sequence is also required to free the mature protease for delivery to the lysosome/endosome compartment. A nine-amino acid prodomain loop motif, implicated in prodomain-receptor interactions in mammalian cells, is conserved in the protozoa. Site-directed mutagenesis now confirms the importance of this loop to protease trafficking and suggests that a protein motif targeting signal for lysosomal proteases arose early in eukaryotic cell evolution.
ChemInform Abstract: NMR Study of the Influence of Adsorbed Sulfur on Hydrogen Chemisorption on Supported Ruthenium Catalysts. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Studies on Tyrosine Transfer Ribonucleic Acid, a Sulfur-rich Species from Escherichia coli (1967)

Abstract A purified species of tyrosine transfer RNA has been isolated by countercurrent techniques and shown to contain 2 4-thiouridylate residues per molecule. These thionucleotides may be titrated quantitatively with p-hydroxymercuribenzoate. Denaturation studies with heat or urea indicate that they are probably hydrogen-bonded in the tRNA. Iodine oxidation of the purified tRNA leads to the formation of a disulfide bond between the thionucleotides without, in this case, changing the amino acid acceptor activity of the molecule. Disulfide formation is accompanied by a slight loss in secondary structure, as shown by a decrease in the Tm and an increase in the E(p). Studies in the ultracentrifuge indicate that the sedimentation of the disulfide form is not greatly changed from that of the native form and that therefore the disulfide bond must be intra- rather than intermolecular.
Chordoma of the Sacrum and Vertebral Bodies (2009)

Chordomas are relatively rare tumors of bone. These primary malignant lesions occur throughout the spinal column and often show advanced growth at the time of diagnosis. Because such tumors are minimally responsive to radiation and chemotherapy, surgical resection is the mainstay of treatment. Patient survival and local control are associated with the ability to achieve wide surgical margins during excision. However, surgical morbidity may be substantial given the propensity for chordomas to abut or surround neural, vascular, and visceral structures. Thus, early recognition is essential, and treatment by a multidisciplinary team is ideal.
A Three-Dimensional Load Sharing Model of Planetary Gear Sets Having Manufacturing Errors (2015)

Planet-to-planet load sharing is a major design and manufacturing tolerancing issue in planetary gear sets. Planetary gear sets are advantageous over their countershaft alternatives in many aspects, provided that each planet branch carries a reasonable, preferably equal, share of the torque transmitted. In practice, the load shared among the planets is typically not equal due to the presence of various manufacturing errors. This study aims at enhancing the models for planet load sharing through a three-dimensional formulation of N-planet helical planetary gear sets. Apart from previous models, the proposed model employs a gear mesh load distribution model to capture load and time dependency of the gear meshes iteratively. It includes all three types of manufacturing errors, namely constant errors such as planet pinhole position errors and pinhole diameter errors, constant but assembly dependent errors such as nominal planet tooth thickness errors, planet bore diameter errors, and rotation and assembly dependent errors such as gear eccentricities and run-outs. At the end, the model is used to show combined influence of these errors on planet load sharing to aid designers on how to account for manufacturing tolerances in the design of the gears of a planetary gear set.
Comparative linewidth measurements on chrome and MoSi structures using newly developed microscopy methods (2003)

Inspection and linewidths measurements of subwavelength structures using optical microscopy are severely confined both by the limited resolution and by a manifold of light-structure interactions affecting the optical image. To receive a better understanding of these interactions and/or to overcome these limitations new microscopy methods have been developed: Polarization-interference-microscopy permits the accurate measurement of the birefringence which is induced by the form of the structures. By interferometric comparison of the TE and TM-polarized image this method provides selective edge detection and localisation in the subwavelength regime because the polarisation difference is situated at the topographical changes of the structure. Two new methods of dark field microscopy ,"alternating grazing incidence dark field microscopy" and "frustrated internal total reflection microscopy", make it possible to suppress optical proximity effects and to overcome the resolution limit of conventional dark field microscopy. For a characterisation of the qualitative and quantitative influence of different influencing variables on measurements of the size of subwavelength structures we performed comparative linewidths measurements on Chrome and phase shifting MoSi photomask structures. The deliverables are compared with rigorous numerical simulations.
Photocathodes based on graphene nanoplatelet emitters on semi-insulating GaAs photoswitch (2014)

A simple photocathode based on graphene nanoplatelets glued on semi-insulating (s.i.) GaAs was fabricated and used for field electron emission in a diode configuration. The graphene nanoplatelets act as field emitter array with low turn-on field. The photomodulation was achieved with a GaAs photoswitch in series to the bottom of the graphene nanoplatelet emitters. The position and power of the laser illumination (800 nm) was not critical for photomodulation.
The Genetics and Molecular Biology of Seizure Susceptibility in Drosophila (2009)

There has been an increased interest recently in various Drosophila models of human disease. The goals are to uncover the fundamental biological principles underlying causes and cures of human pathology utilizing the power of Drosophila genetics. A particularly exciting prospect is that new therapeutics could be forthcoming through identification of disease-causing genes followed by targeted drug development or by the development of platforms for high-throughput drug screening. This chapter reviews a model of human epilepsy based on a set of seizure-sensitive Drosophila mutants that exhibit features resembling some human epilepsies. Especially interesting are descriptions of a novel class of mutations that are second-site seizure-suppressor mutations. These mutations revert epilepsy phenotypes back to the wild-type range of seizure susceptibility. The genes responsible for seizure suppression are cloned with the goal of identifying targets for lead compounds that may be developed into new anti-epileptic drugs (AEDs).
Bypass DNA Polymerases (2010)

Chemical carcinogens modify DNA, resulting in either blocked replication or mutation. The so-called bypass, or translesion synthesis, DNA polymerases were unknown until the late 1990s but are now recognized to play very important roles in the processing of carcinogen-modified DNA. The known eubacterial, archaebacterial, and eukaryotic DNA polymerases are discussed, including what is presently known about their selectivity in copying past DNA adducts, their structures, and their regulation. Overall, DNA polymerases use a variety of means to replicate damaged DNA, although many of the phenomena are now recognized to fall into a limited number of major mechanisms. More insight is still needed to understand the trafficking of DNA (and RNA) polymerases at sites of DNA damage.
Applications of entropic spanning graphs (2002)

This article presents applications of entropic spanning graphs to imaging and feature clustering applications. Entropic spanning graphs span a set of feature vectors in such a way that the normalized spanning length of the graph converges to the entropy of the feature distribution as the number of random feature vectors increases. This property makes these graphs naturally suited to applications where entropy and information divergence are used as discriminants: texture classification, feature clustering, image indexing, and image registration. Among other areas, these problems arise in geographical information systems, digital libraries, medical information processing, video indexing, multisensor fusion, and content-based retrieval.
Synthese von 4-Hydroxy-2H-pyran-2-onen (Enolether ; 16) (1985)

Enolether 1 werden mit Malonyldichloriden 2 zu Pentansäurederivaten 3 acyliert, deren Cyclisierung mit konz. Schwefelsäure/10% SO3 zu in 6-Stellung unsubstituierten 4-Hydroxy-2H-pyran-2-onen 4 führt. Die Bildung von Pyryliumsalzen ist entscheidend für die Vermeidung von Nebenreaktionen. Spektroskopische Untersuchungen beweisen das Vorliegen der Verbindungen 4 in der angegebenen α-Pyranon-Struktur B.
Qualité des données multi-sources et recommandation multi-critère (1999)

International audience
Split Pectoralis Major Tendon Transfer for the Treatment of Serratus Anterior Palsy (2001)

Scapular winging secondary to serratus anterior palsy was first described nearly three centuries ago. Since that time numerous procedures, dynamic and static in design, have been developed for the treatment of this clinical entity. Recent clinical studies demonstrate excellent results with the use of a split pectoralis major transfer to the inferior angle of the scapula. Autologous tendon grafts such as fascia lata or semitendinosus/gracilis may be used to augment the transfer. Successful direct transfer of the pectoralis major tendon, which may lower donor site morbidity associated with graft harvest, has been recently described. Overall, the literature reports satisfactory outcomes in 81% to 100% of patients treated with the pectoralis major transfer.
Toxin Gene Content of the Lyon Methicillin-Resistant <i>Staphylococcus aureus</i> Clone Compared with That of Other Pandemic Clones (2006)

The methicillin-resistant Staphylococcus aureus (MRSA) Lyon clone, detected throughout France, contains the enterotoxin A gene (sea), like other pandemic clones of clonal complex 8 (CC8). The egc locus was detected in MRSA pandemic clones of CC5, CC22, and CC45, occasionally with the toxic shock syndrome toxin 1 gene. The representative strain of the EMRSA-16 clone (CC30) harbored both sea and the egc locus.
Développement de lasers à fibres cristallines dopées Néodyme et Ytterbium (2008)

Séminaire
Effect of niceritrol on fibrinolysis and lipoprotein (a) levels In patients with coronary artery disease (1996)

This study demonstrated that niceritrol administration decreases PAI activity and t-PA antigen levels together with Lp(a) levels in patients with coronary artery disease. These observations suggest that niceritrol administration may tend to normalize fibrinolysis in such patients.
Stagonolides B−F, Nonenolides Produced by <i>Stagonospora cirsii</i>, a Potential Mycoherbicide of <i>Cirsium arvense</i> (2007)

Stagonospora cirsii, a fungal pathogen isolated from Cirsium arvense and proposed as a potential mycoherbicide of this perennial noxious weed, produces phytotoxic metabolites in liquid and solid cultures. Recently, the main metabolite, stagonolide (1), with interesting phytotoxic properties, was isolated from a liquid culture and characterized as a new nonenolide. In the present work this same fungus, grown in solid culture, exhibited an increased capacity to produce nonenolides. Five new nonenolides, named stagonolides B-F (2-6), were isolated and characterized using spectroscopic methods. When tested by a leaf disk puncture assay at a concentration of 1 mg/mL, these compounds showed no toxicity to C. arvense and Sonchus arvensis, whereas stagonolide (1) was highly toxic. Stagonolide (1) and stagonolide C (3) were weakly toxic to Colpoda steinii, a protozoan, when tested at 0.05 mg/mL, with the other stagonolides nontoxic. A number of structure-activity relationship observations were made.
Interactions between immune cells and antibody in protection from fatal Sindbis virus encephalitis (1979)

Transfer of anti-Sindbis virus serum, obtained from peripherally inoculated donors, protected mice from an otherwise fatal intracerebral infection with neuroadapted Sindbis virus (NSV). F(ab)'2 preparations of serum were not protective, indicating that the Fc piece of immunoglobulin G was important. Complement-depleted animals were protected with anti-NSV serum, ruling out as essential the complement-fixing function of the Fc piece. The presence of protective antibody correlated with the ability of serum to inhibit T-cell cytotoxicity. However, experiments using athymic nude mice showed that T cells played no role in killing the mice since the 50% lethal dose was the same as that in normal BALB/c mice, and that T cells were not required for protection since athymic nude mice were protected with antibody alone. Cyclophosphamide treatment of NSV-infected mice ablated the protective capacity of anti-NSV serum. Therefore, a non-T cell, cyclophosphamide-sensitive cell was required for antibody-mediated protection.