gebhart/patrepeval huggingface dataset:
Conformational analysis via heteronuclear correlation NMR spectroscopy (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational analysis via heteronuclear correlation NMR spectroscopyBaifei Zeng, Ralph M. Pollack, and Michael F. SummersCite this: J. Org. Chem. 1990, 55, 8, 2534–2536Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/jo00295a054https://doi.org/10.1021/jo00295a054research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ESBL Genotypes in Fluoroquinolone‐Resistant and Fluoroquinolone‐Susceptible ESBL‐Producing <i>Escherichia coli</i> Urinary Isolates in Manitoba (2006)

CTX-M-15 in E coli is strongly associated with an MDR phenotype compared with other genotypes. CTX-M-14 is associated with FQ resistance only. PFGE suggests clonality of CTX-M-15-producing isolates within and among hospitals.
The Amino Acid Sequences of Glycopeptides Obtained from Taka-Amylase A with Trypsin and Chymotrypsin (1973)

Glycopeptides were obtained from reduced and carboxymethylated Taka-amylase A [EC 3.2.1.1] by digestion with trypsin and chymotrypsin and purified, and their amino acid sequences were determined. The sequence of a glycopeptide obtained with trypsin, Tl, was deduced to be Asn-Glu-Trp-Tyr-Asp-Trp-Val-Gly-Ser-Leu-Val-Ser-Asn(CHO)-Tyr-Ser-Ile-Asp-Gly-Leu-Arg. This satisfies the hypothesis that the asparagine linked to the N-acetylglucosamine of the carbohydrate group is followed by residue X and then by a threonine or serine residue.
Biotransformation of Chloroaromatics: the Impact of Bioavailability and Substrate Specificity (2004)

The effect of surfactants on the biodegradation of mono-aromatic hydrocarbons such as benzene, chlorobenzene and 1,2-dichlorobenzene by an Escherichia coli JMI09(MI) recombinant strain, carrying a gene cluster containing the genes for benzene dioxygenase, cis-benzene dihydrodiol dehydrogenase, and catechol 2,3-dioxygenase from Pseudomonas putida ML2, has been investigated. We observed that the efficiency of the benzene dioxygenase catalyzed conversions to cis-dihydrodiols depends on the balance among real substrate specificity, bioavailability, and toxicity effects of highly concentrated aromatic hydrocarbons. The utilization of non ionic surfactants makes it possible to partly overcome the limiting step of biodegradation processes for scarcely water soluble hydrocarbons hindered by their limited bioavailability.Furthermore the cis-benzene dihydrodiol dehydrogenase and the extradiol catechol 2,3-dioxygenase, which in the presently analyzed biodegradative pathway should further degrade the pollutants, are known, the first to be selectively specific for the (lR,2R)-dihydrodiol derivative which is not produced by the benzene dioxygenase, the second, to be dead-end inhibited by the corresponding chlorinated catechois. In the present example this results in the accumulation of the corresponding chlorinated cis-dihydrodiols which can be useful for asymmetric synthesis.On the other hand the practical utilization of the system for bioremediation purposes requires the efficient conversion of the chlorinated catechols by specific intradiol ring-cleaving dioxygenases, the crystal structures of some of these last enzymes are currently under analysis in our laboratory to understand the structuralfunctional correlations. Preliminary data show overall structures similar to the catechol 1,2-dioxygenase from Acinetobacter sp. ADP1 thus suggesting that the substrate specificity differences are mainly related to subtle differences in the catalytic site.
The Effect of Ankle Position on Pelvic Floor Muscle Contraction Activity in Women (2009)

Pelvic floor muscle exercises performed with active ankle positions may increase the effectiveness of these exercises. Further studies are required to elucidate mechanisms for this finding.
Coronary Hemodynamics Simulated For The Normal State And During Therapeutic Interventions (2005)

The coronary vasculature of the Icft ventricle of thc heart is represented in a lumped parameter modcl, consisting of an arterial, a microcirculatory and a venous compartment. The differential equations are solved for the boundary conditions of coronary sinus interventions both during normal arterial perfusion and coronary artery obsuuction. representation of the venous compartment, in particular of iB volume dependent compliance [9]. In this scnsc, thc prcscnt modcl is an advantagc as compared to previous approaches [lo]. Based on adcquate reproduction of venous hemodynamics, we found for coronary sinus occlusion in thc undiscased statc that oscillating flow between microcirculatory and venous compartment is able to renew in each cardiac cyclcabout two thirds of the blood stored in the microcirculation [91.
Odor from Industrial Hog Farming Operations and Mucosal Immune Function in Neighbors (2004)

The authors evaluated whether exposure to malodor from industrial hog farming operations has a psychophysiologically mediated immunosuppressive effect on secretory immunoglobulin A (sIgA) in neighbors. Fifteen adults living within 2.4 km (1.5 mi) of at least one hog farming operation rated odor intensity on a 9-point scale and provided saliva samples twice daily for two weeks. The authors used hierarchical regression to model the association between reported odor and sIgA; study participants were their own controls. The natural log of slgA concentration and secretion rate declined, on average, 0.058 (0.032) and 0.116 (0.103), respectively, for each incremental 1-unit increase in reported odor from 4 to 9, adjusted for time of day, suggesting reduced levels of sIgA in response to moderate or high odor. Findings support the hypothesized immunosuppressive effect of malodor on mucosal immunity and provide preliminary data useful in understanding health effects related to malodor from industrial hog farming operations.
Elaboration de matériaux composites à propriétés furtives par un procédé de polymérisation en suspension (1995)

International audience
A comparison of 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging subcutaneous HER2-positive tumor xenografts in athymic mice using microSPECT/CT or microPET/CT (2011)

We conclude that 111In-DOTA-trastuzumab Fab was more specific than 64Cu-DOTA-trastuzumab Fab for imaging HER2-positive tumors, especially those with low receptor density. This was due to higher levels of circulating radioactivity for 64Cu-DOTA-trastuzumab Fab which disrupted the relationship between HER2 density and T/B ratios. Use of alternative chelators that more stably bind 64Cu may improve the association between T/B ratios and HER2 density for 64Cu-labeled trastuzumab Fab.
Optimal weighted watermarking for still images (2014)

The secure digital watermarking method for digital images is proposed. This method is based on error correcting codes (ECC) that are perfect in weighted Hamming metric. The usage of perfect ECC guarantees the limited number of errors (distortions of initial image) that occur in watermarking process. The use of ECC that are perfect in weighted Hamming metric increases the efficiency of the watermarking, such as increasing container volume, taking into account specific of human vision system by applying the concept of weighted container. The method of security increasing for weighted watermarking is represented in this paper.
Evolution of the Envelope Glycoprotein of HIV-1 Clade B toward Higher Infectious Properties over the Course of the Epidemic (2018)

We showed previously that during the HIV/AIDS epidemic, the envelope glycoprotein (Env) of HIV-1, and in particular, the gp120 subunit, evolved toward an increased resistance to neutralizing antibodies at a population level. Here, we considered whether the antigenic evolution of the HIV-1 Env is associated with modifications of its functional properties, focusing on cell entry efficacy and interactions with the receptor and coreceptors. We tested the infectivity of a panel of Env-pseudotyped viruses derived from patients infected by subtype B viruses at three periods of the epidemic (1987 to 1991, 1996 to 2000, and 2006 to 2010). Pseudotyped viruses harboring Env from patients infected during the most recent period were approximately 10-fold more infectious in cell culture than those from patients infected at the beginning of the epidemic. This was associated with faster viral entry kinetics: contemporary viruses entered target cells approximately twice as fast as historical viruses. Contemporary viruses were also twice as resistant as historical viruses to the fusion inhibitor enfuvirtide. Resistance to enfuvirtide correlated with a resistance to CCR5 antagonists, suggesting that contemporary viruses expanded their CCR5 usage efficiency. Viruses were equally captured by DC-SIGN, but after binding to DC-SIGN, contemporary viruses infected target cells more efficiently than historical viruses. Thus, we report evidence that the infectious properties of the envelope glycoprotein of HIV-1 increased during the course of the epidemic. It is plausible that these changes affected viral fitness during the transmission process and might have contributed to an increasing virulence of HIV-1.<b>IMPORTANCE</b> Following primary infection by HIV-1, neutralizing antibodies (NAbs) exert selective pressure on the HIV-1 envelope glycoprotein (Env), driving the evolution of the viral population. Previous studies suggested that, as a consequence, Env has evolved at the HIV species level since the start of the epidemic so as to display greater resistance to NAbs. Here, we investigated whether the antigenic evolution of the HIV-1 Env is associated with modifications of its functional properties, focusing on cell entry efficacy and interactions with the receptor and coreceptors. Our data provide evidence that the infectious properties of the HIV-1 Env increased during the course of the epidemic. These changes may have contributed to increasing virulence of HIV-1 and an optimization of transmission between individuals.
Broadly neutralizing antibody-mediated protection of macaques against repeated intravenous exposures to simian-human immunodeficiency virus (2021)

Significant protection against repeated intravenous SHIV challenges was observed following administration of 10-1074 and 3BNC117 and was due primarily to 10-1074. Our findings extend preclinical studies of bNAb-mediated protection against mucosal SHIV acquisition and support the possibility that intermittent subcutaneous injections of 10-1074 could serve as long-acting preexposure prophylaxis for persons who inject drugs.
Successfully Treated <i>Escherichia coli</i>-Induced Emphysematous Cyst Infection with Combination of Intravenous Antibiotics and Intracystic Antibiotics Irrigation in a Patient with Autosomal Dominant Polycystic Kidney Disease (2013)

A 62-yr-old woman with an autosomal dominant polycystic kidney disease (ADPKD) was admitted to our hospital for further evaluation of intermittent fever, nausea and left flank discomfort. The computed tomography (CT) scan revealed a gas-forming, infectious cyst of approximately 8.1 cm in size in left kidney lower pole. Escherichia coli was identified from the cyst fluid culture examination. Her symptoms improved only after the concomitant use of intravenous ciprofloxacin and an intracystic irrigation of ciprofloxacin through a percutaneous cystostomy drainage. Our case presents the successfully treated emphysematous cyst infection with combination of intravenous antibiotics and intracystic antibiotic therapy instead of surgical management.
One-year results of gastric peroral endoscopic myotomy for refractory gastroparesis: a French multicenter study (2020)

The results confirm the efficacy of G-POEM for the treatment of refractory gastroparesis, as evidenced by a 65.8 % clinical success rate at 1 year. Although G-POEM is promising, prospective sham-controlled trials are urgently needed to confirm its efficacy and identify the patient populations who will benefit most from this procedure.
Synthesizing realistic facial expressions from photographs (2005)

We present new techniques for creating photorealistic textured 3D facial models from photographs of a human subject, and for creating smooth transitions between different facial expressions by morphing between these different models. Starting from several uncalibrated views of a human subject, we employ a user-assisted technique to recover the camera poses corresponding to the views as well as the 3D coordinates of a sparse set of chosen locations on the subject's face. A scattered data interpolation technique is then used to deform a generic face mesh to fit the particular geometry of the subject's face. Having recovered the camera poses and the facial geometry, we extract from the input images one or more texture maps for the model. This process is repeated for several facial expressions of a particular subject. To generate transitions between these facial expressions we use 3D shape morphing between the corresponding face models, while at the same time blending the corresponding textures. Using our technique, we have been able to generate highly realistic face models and natural looking animations.
Heteroarene‐fused π‐conjugated main‐chain polymers containing 4,7‐bis(4‐octylthiophen‐2‐yl)benzo[c][1,2,5]thiadiazole or 2,5‐bis(4‐octylthiophen‐2‐yl)thiazolo[5,4‐d]thiazole and their application to photovoltaic devices (2010)

Abstract Two conjugated main‐chain polymers consisting of heteroarene‐fused π‐conjuagted donor moiety alternating with 4,7‐bis(5‐bromo‐4‐octylthiophen‐2‐yl)benzo[c][1,2,5]thiadiazole (P1) or 2,5‐bis(5‐bromo‐4‐octylthiophen‐2‐yl) thiazolo[5,4‐d]thiazole (P2) units have been synthesized. They are intrinsically amorphous in nature and do not exhibit crystalline melting temperatures during thermal analysis. The effect of the fused rings on the thermal, optical, electrochemical, charge transport, and photovoltaic properties of these polymers has been investigated. The polymer (P1) containing 4,7‐bis(5‐bromo‐4‐octylthiophen‐2‐yl)benzo[c][1,2,5] thiadiazole has a broad absorption extending from 300 to 600 nm with optical bandgaps as low as 2.02 eV. The HOMO levels (5.42 to 5.29 eV) are more sensitive to the choice of acceptor. The polymers were employed to fabricate organic photovoltaic cells with methanofullerene [6,6]‐phenyl C71‐butyric acid methyl ester (PC 71 BM). As a result, the polymer solar cell device containing P1 had the best preliminary results with an open‐circuit voltage of 0.61 V, a short‐circuit current density of 6.19 mA/cm 2 , and a fill factor of 0.32, offering an overall power conversion efficiency of 1.21%. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010
Development of Water Content Dependent Tissue Dielectric Property Models (2018)

We propose dielectric tissue property models dependent on both water and air content covering the microwave frequency range. Water is the largest constituent of biological tissues and its effect on the dielectric properties of biological tissue has been studied. However, dehydration effects due to thermal heating have not been fully characterized. We combined 1) Maxwell-Fricke mixture theory with a four-pole Cole-Cole equation to include water and air content dependency and as the second approach a different 2) Maxwell mixture model was coupled with a Debye function. The proposed approaches (1 and 2) were able to predict the permittivity (<i>ε</i>') and conductivity (<i>σ</i>) of bovine liver and swine lung tissues at different hydration and inflation states from 1-15 GHz. A second approach coupling Maxwell and Debye models required fewer assumptions and modelled tissue properties with higher accuracy (less than 15% mean percent error in all tissue types). These models may help improve the accuracy of microwave ablation simulation when tissue water content changes as a result of vaporization, and may facilitate personalized treatment planning.
Heterosis of <i>Arabidopsis</i> hybrids between C24 and Col is associated with increased photosynthesis capacity (2012)

Arabidopsis thaliana shows hybrid vigor (heterosis) in progeny of crosses between Columbia-0 and C24 accessions. Hybrid vigor was evident as early as mature seeds and in seedlings 3 d after sowing (DAS). At 3 DAS, genes encoding chloroplast-located proteins were significantly overrepresented (187) among the 724 genes that have greater than midparent values of expression in the hybrid. Many of these genes are involved in chlorophyll biosynthesis and photosynthesis. The rate of photosynthesis was constant per unit leaf area in parents and hybrids. Larger cell sizes in the hybrids were associated with more chloroplasts per cell, more total chlorophyll, and more photosynthesis. The increased transcription of the chloroplast-targeted genes was restricted to the 3-7 DAS period. At 10 DAS, only 118 genes had expression levels different from the expected midparent value in the hybrid, and only 12 of these genes were differentially expressed at 3 DAS. The early increase in activity of genes involved in photosynthesis and the associated phenomena of increases in cell size and number through development, leading to larger leaf areas of all leaves in the hybrid, suggest a central role for increased photosynthesis in the production of the heterotic biomass. In support of this correlation, we found that an inhibitor of photosynthesis eliminated heterosis and that higher light intensities enhanced both photosynthesis and heterosis. In hybrids with low-level heterosis (Landsberg erecta x Columbia-0), chloroplast-targeted genes were not up-regulated and leaf areas were only marginally increased.
The vomeronasal organ is not involved in the perception of endogenous odors (2010)

Chemosensory-based communication is a vital signaling tool in most species, and evidence has recently emerged in support of the notion that humans also use social chemosignals (so-called pheromones) to communicate. An ongoing controversy does exist, however, concerning the receptor organ through which these chemicals are processed. There is a widespread belief that the vomeronasal organ (VNO) is responsible for processing social chemosignals in humans. Here we demonstrate that functional occlusion of the VNO does not change the percept of, sensitivity toward, or functional neuronal processing of a putative human pheromone. Perithreshold and suprathreshold perception of the endogenous chemical androstadienone (AND) were compared, as were positron emission tomography brain activations evoked by AND when the VNO was either occluded or left open. In addition, we compared sensitivity to AND in subjects with an identifiable VNO to those in whom no VNO could be detected. Thus we could examine the effects of the VNO at several different levels of processing. Occlusion or absence of the VNO did not affect either the perceptual measurements or the functional processing of the putative human pheromone, AND. These results provide strong evidence that the human VNO has no obvious function. Pheromonal communication in humans may be conveyed via the main olfactory system.
OC-035 Mechanism of Lactose Intolerance in Irritable Bowel Syndrome: Role of Anxiety, Mucosal Immunity and Visceral Hypersensitivity (2013)

Introduction Many patients, especially those with Irritable Bowel Syndrome (IBS), report food intolerance; however the mechanism underlying these “functional digestive symptoms” is unknown. We assessed the role of psychological factors, mucosal immune activation and visceral sensitivity on the development of lactose intolerance (LI) after ingestion of 20g lactose in IBS patients and healthy controls (HCs) with lactase deficiency: a validated, clinical experimental model of intolerance to poorly absorbed, fermentable foods (Yang et al Clin Gastro Hep 2013 in publication). Methods IBS-D patients meeting Rome III criteria (n = 277) and age/sex matched HCs (n = 64) underwent a 20g lactose hydrogen breath test (LHBT) with measurement of hydrogen production, abdominal distention, and LI symptoms. Hospital Anxiety and Depression Score assessed psychologic state. Barostat measured rectal sensitivity. Additionally, 55 IBS-D patients and 18 HCs completed colonoscopy with colon and terminal ileum (TI) biopsies for quantification of mast cells (MCs), T lymphocytes, and enterochromaffin cells (ECC). Results Hydrogen production and distention were similar in IBS patients and HCs during LHBT; however LI symptoms were more frequent in IBS (54% vs. 28%, P < 0.001), including bloating (39% vs . 14%, P < 0.001), borborygmi (39% vs. 22%, P = 0.010), pain (31% vs. 11%, P = 0.001) and diarrhoea (29% vs. 9%, P = 0.001). IBS patients were more anxious (p < 0.001) and had higher rectal sensitivity than HCs ( P = 0.001). Multivariate analysis indicated that hydrogen production increased the likelihood of bloating (OR2.2 (95%CI 1.1–4.4), P = 0.028) and borborygmi (OR12.4 (3.3–45.8), P < 0.001), but not objective distention ( P = 0.673). Visceral hypersensitivity also associated with bloating (OR6.6 (1.7–25.0), P = 0.005) and total symptom score (OR3.7 (1.3–10.9, P = 0.014). A planned subanalysis showed that, compared to IBS patients with no symptoms, those with LI were more anxious (p = 0.045) and more likely to have visceral hypersensitivity (p < 0.001). In those that had colonoscopy, IBS patients with LI (25/55 (45%)) had increased MCs (p < 0.006), T-cells and ECC (both p < 0.05) in proximal colonic and TI mucosa compared to patients without LI and HCs. Multivariate analysis indicated that total LI symptom score was associated with anxiety (r = 0.519, P < 0.001), MCs in terminal ileum (r = 0.650, P < 0.001) and visceral sensitivity (r = 0.629, P < 0.001). Conclusion Gas production and sensitivity to luminal distension both contribute to digestive symptoms after lactose ingestion in patients with lactase deficiency. IBS-D patients with LI are characterised by anxiety, evidence of mucosal immune activation and visceral hypersensitivity. Disclosure of Interest None Declared