gebhart/patrepeval huggingface dataset:
High-speed optical signal processing and detection: Toward efficient dispersion-engineered parametric devices controlled by few photons (2015)

In this Internet era, rapid transitioning of many aspects of medical, defense and commercial applications to digital platforms dictates their heavy reliance on optical communication systems. This trend places severe challenges on contemporary communication systems, expected to provide wide-bandwidth services and high degree of information security, with minimum energy dissipation. To meet the rising bandwidth demand, current bandwidth limited technology requires implementation of parallel processing; however, energy dissipation of such a system is globally and environmentally significant. A solution to this problem is envisioned in a form of an optical processor, a device recognized for its high speed, low loss and signal quality preservation. In this dissertation we investigate two optical processor roles: direct signal processing role (all-optical switching) and preprocessing role in preamplified few photon detection. \tIn the direct signal processing role, an optical switch controls the state of one wave by a low-energy control signal. It is realized in a highly nonlinear fiber, a medium acclaimed for its inherent femtosecond response time, a low loss and a high figure of merit. The switching functionality is implemented by employing the four wave mixing process in the depleted pump regime. To maximize the energy exchange, we revisit the saturated parametric mixer phase matching condition and propose a novel dispersion engineering method enhancing the performance. This study advances the understanding of the phase-matched interaction in the saturated parametric mixer and enables the first realization of a few-photon controlled silica-fiber-based device. \tIn the preprocessing role, the all-fiber photonic sampler is implemented prior to detection of a preamplified few photon signal with a low duty cycle; the sampler function is limited to amplified spontaneous emission noise alleviation. The proposed few photon detection method shows an order of magnitude improvement in the Bit Error Ratio and detection efficiency with respect to conventional preamplified receiver, and operates at speed beyond the reach of current single photon detector technology.
Learning Agent for a Heat-Pump Thermostat with a Set-Back Strategy Using Model-Free Reinforcement Learning (2015)

The conventional control paradigm for a heat pump with a less efficient auxiliary heating element is to keep its temperature set point constant during the day. This constant temperature set point ensures that the heat pump operates in its more efficient heat-pump mode and minimizes the risk of activating the less efficient auxiliary heating element. As an alternative to a constant set-point strategy, this paper proposes a learning agent for a thermostat with a set-back strategy. This set-back strategy relaxes the set-point temperature during convenient moments, e.g., when the occupants are not at home. Finding an optimal set-back strategy requires solving a sequential decision-making process under uncertainty, which presents two challenges. The first challenge is that for most residential buildings, a description of the thermal characteristics of the building is unavailable and challenging to obtain. The second challenge is that the relevant information on the state, i.e., the building envelope, cannot be measured by the learning agent. In order to overcome these two challenges, our paper proposes an auto-encoder coupled with a batch reinforcement learning technique. The proposed approach is validated for two building types with different thermal characteristics for heating in the winter and cooling in the summer. The simulation results indicate that the proposed learning agent can reduce the energy consumption by 4%–9% during 100 winter days and by 9%–11% during 80 summer days compared to the conventional constant set-point strategy.
Detection of Icing and Related Loss of Control Effectiveness in Regional and Corporate Aircraft (1999)

<div class="section abstract"><div class="htmlview paragraph">This paper presents a method of detecting aircraft icing by monitoring its effects on aircraft dynamics. This paper shows that uncontrolled icing on control surfaces directly influences control effectiveness. Using data from onboard attitude and navigation sensors via highly computationally efficient algorithms, the control effectiveness is estimated, thereby detecting icing. Using actual flight test data from NASA Lewis Research Center, this paper demonstrates the ability of this method to detect the loss of elevator effectiveness that occurs with uncontrolled horizontal stabilizer icing that could result from a failed deicing boot. The method is generally applicable to loss of control effectiveness due to icing.</div><div class="htmlview paragraph">Icing affects the aerodynamic performance of aircraft by contaminating the aerodynamic surfaces. Without anti-icing equipment icing, if sufficiently severe, can relatively quickly lead to a situation in which controllable flight is impossible. Even aircraft with anti-icing equipment are potentially susceptible to icing under certain conditions. Some turboprop aircraft that have de-icing boots on the leading edge of aerodynamic surfaces may experience wing and tailplane icing behind the de-icing boots. Moreover, de-icing boots can fail due to a variety of conditions including holes produced by rocks etc. In particular the failure of a horizontal stabilizer boot can occur under such circumstances that the flight crew is unaware of the failure.</div></div>
Purification and analysis of the neutral glycan moiety of glycosyl phosphatidylinositol from porcine thyroid cells (1999)

Metabolic labelling of inositolphosphate glycan with radioactive precursors is not sufficient to characterize and assess the involvement of the glycosyl phosphatidylinositol/inositolphosphate glycan (GPI/IPG) system in porcine thyroid cell signal transduction machinery. A protocol is described for the isolation and purification of free GPI using differential polarity of lipids and sequential thin layer chromatography. The purification until homogeneity of GPI constitutes a required step for gas chromatographic analysis. Next, successive chemical treatments allowed us to remove the neutral glycan moiety of thyroidal GPI, and its composition was obtained by gas chromatography. The proposed structure is consistent with data available for GPI anchor, but differs from compositional analysis data reported for insulin-sensitive GPI. Our results support the existence in porcine thyroid cells of the GPI/IPG system, which can take part in TSH-dependent signal transduction processes.
On the importance of offshore data for magnetotelluric studies of ocean‐continent subduction systems (2002)

The presence of water in the mantle wedge overlying a subduction zone is expected to significantly enhance electrical conductivity, raising it above that of the cold subducting slab, or surrounding regions of dehydrated mantle. This suggests that magnetotelluric (MT) transects across subduction systems, measuring regional electrical conductivity structure, might be able to indirectly trace the pathways of water migration into the mantle. For ocean‐continent subduction, it is logistically simpler to collect MT transects on the continental side of the system. However, we show that such land data are relatively insensitive to details of the electrical connections between the ocean and mantle. In contrast, seafloor measurements on the landward and seaward side of the trench are very sensitive to these electrical connections, and are essential to understanding the electrical structure of the entire subduction system. In particular, the conductivity structure of the hydrated mantle wedge overlying the slab can only be studied using offshore MT data. We demonstrate this result using a model of an ocean‐continent system, although our results can be generalised to other subduction geometries.
Properties of cubic boron nitride films prepared by ion beam assisted deposition (2002)

Boron nitride films were prepared by ion beam assisted deposition (IBAD). The films were synthesized on Si[100] substrates by depositing boron vapor under simultaneous bombardment with nitrogen ions and nitrogen-argon mixture ions. Properties of cubic boron nitride (cBN) films are studied especially regarding the crystallization of the films and the valence band spectra obtained from X-ray photoelectron spectroscopy (XPS). Structural analysis by Fourier transform infrared spectroscopy (FTIR) and cross-sectional transmission electron microscopy (TEM) confirms that polycrystalline films with a high cBN fraction were synthesized. Valence-band spectra obtained from XPS were measured to provide a method for characterization of the BN phases on the basis of experimental observations for the bulk cBN and hBN samples and theoretical prediction of densities of states.
Exceptional response to neoadjuvant targeted therapy with the selective RET inhibitor selpercatinib in RET-fusion-associated sarcoma (2022)

With the increasing use of next-generation sequencing, highly effective targeted therapies have been emerging as treatment options for several cancer types. Recurrent gene-fusions have been recognized in sarcomas; however, options for targeted therapy remain scarce. Here, we describe a case of a sarcoma, associated with a RET::TRIM33-fusion gene with an exceptional response to a neoadjuvant therapy with the selective RET inhibitor selpercatinib. Resected tumor revealed subtotal histopathologic response. This is the first report of successful targeted therapy with selpercatinib in RET-fusion-associated sarcomas. As new targeted therapies are under development, similar treatment options may become available for sarcoma patients.
Abstract 160: Association Between Time From Stroke Onset and Flair Lesion Intensity is Modified by Status of Collateral Circulation (2016)

Introduction and hypothesis: In acute stroke patients the intensity of a FLAIR lesion in a region of diffusion restriction is associated with time from symptom onset. The DWI/FLAIR mismatch is currently used in trials for treatment of stroke patients with unknown onset time. However the accuracy of the DWI/FLAIR mismatch to predict symptom onset before 4.5h remains moderate. We hypothesized that collateral status, as assessed by the previously described hypoperfusion intensity ratio (HIR) could modify the association between time from stroke onset and FLAIR lesion intensity. Methods: From the ‘Ax200 for ischemic stroke trial’ 141 patients were included. Quantitative FLAIR maps were calculated in a voxel-based manner. For each voxel the relative signal intensity (rSI) was determined by the ratio of the signal intensity in that voxel and the median of the signal intensity in a sphere with radius 15mm positioned in the homologue voxel in the other hemisphere. Lesion volumes based on diffusion-weighted imaging and perfusion-weighted imaging were determined using RAPID software. The HIR was defined as the proportion of a Tmax >6 s lesion volume with a Tmax >10 s delay. A previously defined HIR-threshold of ≤ 0.4 dichotomized good versus poor collaterals. We studied the interaction between collateral circulation and the association between time from symptom onset and FLAIR intensity. Results: Time from symptom onset was associated with the mean FLAIR intensity in the region of non-reperfused core (b=1.05; 95%CI: 1.01-1.1). We identified an interaction between this association and collateral status (p=0.036). ROC analysis of FLAIR intensity to predict stroke onset before 4.5h showed an AUC of 0.66 (95% CI: 0. 49-0.83) for patients with good collaterals and 0.80 (95%CI: 0.71-0.90) for patients with poor collaterals. Conclusions: Our findings suggest that the progression of FLAIR intensity with time varies depending on the quality of the collateral flow. Accordingly collateral circulation influences the accuracy of FLAIR lesion intensity to predict stroke onset before 4.5h. This could be of particular importance for clinical trials enrolling patients based on the DWI/FLAIR mismatch.
Complexity of complement activation in sepsis (2008)

The complement system is one of the key players in the defence against infections. Its activation during the innate immune response leads to the generation of several proteins that contribute to the lysis and opsonization of microorganisms, regulate inflammatory reactions and bridge innate immunity with the subsequent adaptive immune response. Complement is also activated in overwhelming bacterial infections that lead to sepsis, and its protective functions play a role in this frequently lethal disorder. However, despite its role in protection, complement can also contribute to the development of severe complications that significantly worsen the prognosis of septic patients. Therefore, an understanding of the mechanisms involved in the activation of complement during sepsis is essential to our efforts to introduce rational therapies targeting complement to the treatment of patients suffering from this condition. This review presents a current view of the mechanisms involved in the activation of complement in sepsis, in the context of the multiple interactions between complement and other biological systems that are involved in the pathogenesis of this disorder.
NF-κB as a Prognostic Marker and Therapeutic Target in Chronic Lymphocytic Leukemia (2009)

Chronic lymphocytic leukemia is the most common adult leukemia and is currently incurable with conventional chemotherapeutic agents. Over the last few years, significant discoveries have been made regarding the biology that underpins this disease. These new insights have allowed us to develop more rational prognostic tools and identify promising novel therapeutic targets. In this review, we highlight the importance of both constitutive and inducible DNA binding of the transcription factor NF-κB in chronic lymphocytic leukemia. We describe the current knowledge regarding the activity and function of specific NF-κB subunits in this disease, and discuss the complex mechanisms that regulate NF-κB activation in vivo. In addition, we provide compelling evidence for the utility of the NF-κB subunit, Rel A, as a prognostic marker and as a therapeutic target in this disease, and we also describe how this protein may contribute to the drug resistance commonly encountered with this condition.
A Simple Interframe Coder For Video Telephony (1971)

The technique of exchanging resolution according to the amount of movement in a picture has been previously described; in stationary parts of the picture the temporal resolution is reduced while in moving parts of the picture the spatial resolution is reduced. Here, we describe a method of applying resolution exchange to a differentially quantized (DPCM) signal. The resulting channel capacity required for the subjectively satisfactory transmission of the differential signal is halved. The coder is simpler than most interframe coders and should not increase the sensitivity of the system to channel errors.
ChemInform Abstract: CONVENIENT SYNTHESIS OF CRYSTALLINE 1ALPHA,25‐DIHYDROXYVITAMIN D3 (1974)

Abstract 25‐Hydroxy‐cholesterin (I) wird mit Dichlordicyanchinon zu dem Trienon (II) dehydriert, dessen Epoxid (III) durch Metall‐Reduktion in Ammoniak/Tetrahydrofur in Gegenwart von Ammoniumchlorid zu (IVa) reduziert wird.
Understanding Injectivity in Heterogeneous Reservoirs (1998)

Understanding Injectivity in Heterogeneous Reservoirs Jorge O.S. Pizarro; Jorge O.S. Pizarro Petrobras Search for other works by this author on: This Site Google Scholar Larry W. Lake Larry W. Lake U. of Texas at Austin Search for other works by this author on: This Site Google Scholar Paper presented at the SPE/DOE Improved Oil Recovery Symposium, Tulsa, Oklahoma, April 1998. Paper Number: SPE-39697-MS https://doi.org/10.2118/39697-MS Published: April 19 1998 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Pizarro, Jorge O.S., and Larry W. Lake. "Understanding Injectivity in Heterogeneous Reservoirs." Paper presented at the SPE/DOE Improved Oil Recovery Symposium, Tulsa, Oklahoma, April 1998. doi: https://doi.org/10.2118/39697-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search nav search search input Search input auto suggest search filter All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Improved Oil Recovery Conference Search Advanced Search AbstractThis paper introduces a novel approach to quantify the dependence of injectivity on the heterogeneity and auto correlation of the reservoir permeability distribution. The mathematical formulation of the problem was derived for two geometries representing a vertical cross section and a five-spot pattern. The heterogeneity is modeled by stochastically generated permeability distributions. The scaling of the governing equations, by inspectional analysis, generates a minimal set of dimensionless groups that is able to describe fracture-free injectivity in heterogeneous permeable media. The scaling procedure was validated against available analytical solutions and the importance of each dimensionless group on the dimensionless injectivity evaluated with an extensive set of numerical experiments. The results obtained provide a better understanding of how vertical well injectivity depends on heterogeneity and gives insight into why injectivity calculated from a core permeability average is frequently different from the injectivity manifested by the well in question.P. 421 Keywords: dimensionless group, realization, semivariogram model, inspectional analysis, permeability field, reservoir simulation, spe 39697, cross section, boundary condition, fluid dynamics Subjects: Reservoir Fluid Dynamics, Improved and Enhanced Recovery, Reservoir Simulation, Flow in porous media This content is only available via PDF. 1998. Society of Petroleum Engineers You can access this article if you purchase or spend a download.
Federal Regulation of Parenterals (2018)

This chapter presents an overview of the federal regulation of drugs, with particular emphasis on parenteral drug products and their regulation. The text explains the regulatory process in some detail.
<title>High-performance optical disk mass storage for aerospace imaging systems</title> (1990)

The space programs of the 90's and beyond will employ sophisticated I with high resolution and high data rates . Temporary storage of this data on-board the satellites is an important function. The NASA Spaceflight Optical Disk Recorder (SODR) , currently under development for these future space missions, utilizes advanced techniques and concepts to satisfy these needs.
Characteristics of Minute Hole Dewatering Using Focused Ultrasonic Wave (2016)

Using the focused ultrasound wave for the purpose of removing the residual water in minute hole has been proposed. There are some advantages in dewatering. For example, this method can discharge water as liquid droplet from minute and non-through hole easily. For radiation of ultrasonic wave with strong intensity, an ultrasonic focusing device is applied, then the focus can be arranged at three dimensions. It has been observed that success rate of dewatering depends on the size of the hole. To discuss the success rate, we proposed a dimensionless number which is ratio of surface tension and pressure by ultrasonic wave. The relationship between the surface tension and dewatering behavior at minute holes was observed by using working water with different concentration of ethanol. Then, relationship between the number and success rate of dewatering was plotted on a graph.
InP/InGaAs Based Charge-Coupled Devices For MQW Spatial Light Modulator Applications (1989)

This paper discusses the development of InP based Charge-Coupled Device addressed Multi-Quantum Well Spatial Light Modulators. These devices are based on the quantum-confined Stark effect and promise to be very fast, with response times in the fractional nsec range.
Extremal polyphase sequences (2002)

The unnormalized finite autocorrelation function C(/spl tau/) of the sequence A={a/sub k/}/sup n//sub k=1/ of complex numbers on with the unit circle is defined by C(/spl tau/)=/spl Sigma//sup n-/spl tau///sub k=1/a/sub k/a*/sub k+/spl tau//, with C(0)=n, C(-/spl tau/)=C*(/spl tau/), and |C(n-1)|=1, where z* denotes the complex conjugate of z. We seek the sequence of length n, for each n/spl ges/3, which minimizes the value of max/sub 1/spl les//spl tau//spl les/n-2/|C(/spl tau/)|, and the value T/sub n/=min/sub all sequences/ max/sub 1/spl les//spl tau//spl les/n-2/|C(/spl tau/)| for this minimizing sequence.
Effect of morphine sulfate concentration on flow rate in an implantable reservoir pump (1984)

The effect of morphine sulfate concentration on flow rate in an implantable pump was studied. Solutions containing morphine sulfate 5 mg/3 ml, 10 mg/3 ml, 20 mg/3 ml, and 200 mg/3 ml were prepared from morphine sulfate powder; a solution containing morphine sulfate 20 mg/3 ml with bupivacaine hydrochloride 0.125% was also prepared. Sterile water was used for preparing the morphine solutions and as the control solution. A model 400 Infusaid pump was filled with 50 ml of the drug solution, placed in a water bath at 37 degrees C, and allowed to equilibrate for three hours. Samples of each concentration of morphine solution and control solution were then collected in an analytical graduate over 20-hour periods. Between each collection period, the pump was flushed twice with sterile water. Five samples of each morphine solution and control solution were collected. The osmolality of one sample of each solution was determined to assess drug concentration indirectly; morphine sulfate concentrations were not actually measured. Actual solution volumes collected during the 20-hour collection periods were corrected to 24 hours to allow comparison with the pump's preset daily flow rate. Collection volumes and calculated daily flow rates decreased with increasing morphine sulfate concentrations and solution osmolalities; a significant positive correlation between osmolality and assumed drug concentration was found. The flow rate of the solution containing morphine 200 mg/3 ml was approximately equal to the pump's stated flow rate; flow rates for all other solutions were higher than the stated flow rate.(ABSTRACT TRUNCATED AT 250 WORDS)
Der Mikroprozessor 68000 (1985)

Dieses Buch beschäftigt sich mit einem 16 Bit-Mikroprozessor, genauer, mit dem 68000. Geschrieben ist es ftir diejenigen, die mit Hardware arbeiten. Es liefert Informa tionen und Einzelheiten über die
Catheter Ablation of Scar-Related Ventricular Tachycardia in Patients with Electrical Storm Using Remote Magnetic Catheter Navigation (2010)

Irrigated ablation of scar-related VT using remote MNS is an effective modality for management of the monomorphic VT in patients with ischemic cardiomyopathy with minimal radiation exposure. Programmed left (in addition to right) ventricular stimulation might be necessary to assess acute outcome of the ablation procedure.
A numerical study of non-cavitating and cavitating liquid flow around a hydrofoil (2005)

The results of a workshop concerning the numerical simulation of the liquid flow around a hydrofoil in non-cavitating and cavitating conditions are presented. This workshop was part of the conference “Mathematical and Numerical aspects of Low Mach Number Flows” (2004) and was aimed to investigate the capabilities of different compressible flow solvers for the low Mach number regime and for flows in which incompressible and supersonic regions are simultaneously present. Different physical models of cavitating phenomena are also compared. The numerical results are validated against experimental data.
Bitterstoffe als belebende Wirkstoffe für die Haut (2017)

Schon von Anfang an spielten in der 5000 Jahre alten Ayurvedischen Medizin bitter schmeckende Heilkruter eine wichtige Rolle. Bitterstoffe reduzieren nach ayurvedischer Auffassung das Fett