gebhart/patrepeval huggingface dataset:
POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking (2015)

The Popeye domain-containing 1 (POPDC1) gene encodes a plasma membrane-localized cAMP-binding protein that is abundantly expressed in striated muscle. In animal models, POPDC1 is an essential regulator of structure and function of cardiac and skeletal muscle; however, POPDC1 mutations have not been associated with human cardiac and muscular diseases. Here, we have described a homozygous missense variant (c.602C>T, p.S201F) in POPDC1, identified by whole-exome sequencing, in a family of 4 with cardiac arrhythmia and limb-girdle muscular dystrophy (LGMD). This allele was absent in known databases and segregated with the pathological phenotype in this family. We did not find the allele in a further screen of 104 patients with a similar phenotype, suggesting this mutation to be family specific. Compared with WT protein, POPDC1(S201F) displayed a 50% reduction in cAMP affinity, and in skeletal muscle from patients, both POPDC1(S201F) and WT POPDC2 displayed impaired membrane trafficking. Forced expression of POPDC1(S201F) in a murine cardiac muscle cell line (HL-1) increased hyperpolarization and upstroke velocity of the action potential. In zebrafish, expression of the homologous mutation (popdc1(S191F)) caused heart and skeletal muscle phenotypes that resembled those observed in patients. Our study therefore identifies POPDC1 as a disease gene causing a very rare autosomal recessive cardiac arrhythmia and LGMD, expanding the genetic causes of this heterogeneous group of inherited rare diseases.
A microtiter assay for activation of eosinophils (1998)

A simple microtiter assay for eosinophil activation is described. The assay used 1000-4000 eosinophils/microtiter well, and the design allows for a separate or simultaneous quantitative assessment of eosinophil adhesion to protein-coated microtiter wells and degranulation after stimulation with eosinophil-activating factors. The number of adherent eosinophils is quantified indirectly by expressing the amount of eosinophil cationic protein (ECP) extracted from the adherent fraction of cells in percentage of the total amount of ECP extracted from the cells added to the wells. Degranulation is quantified in the same way by expressing the amount of ECP or eosinophil protein X (EPX) released to the supernatant in percentage of the total amount of ECP or EPX. Known eosinophil-activating agents such as PMA, interleukin (IL)-3, IL-5, GM-CSF, and platelet-activating factor (PAF) all induced a time- and dose-dependent adhesion to albumin-coated wells, whereas L-PAF did not. Kinetic experiments showed that most adhesion occurred within the first 15-30 min, reaching a plateau around 60 min. After prolonged incubation, a decline in adhesion was detected. GM-CSF-induced adhesion was completely inhibited by incubation with monoclonal antibodies directed against the common beta 2-chain (CD18) of the LFA-1, Mac-1, p150,95 complexes. Monoclonal antibodies against CD11a, CD11b, CD11c, VLA-4 ALFA, ICAM-1, VCAM-1, Sialyl-Le(x), ELAM-1, and LECAM had no inhibitory effect. Simultaneous monitoring of adhesion and degranulation after stimulation of eosinophils in albumin-coated wells with either PMA or GM-CSF showed that adhesion always preceded degranulation. Replacing the albumin coating of the microtiter wells with IgG or secretory IgA augmented both the spontaneous and the PMA- or GM-CSF-stimulated responses. In conclusion, the assay allows dynamic evaluation of eosinophil activation and can be used to assess soluble eosinophil-activating factors as well as to study eosinophil activation by solid-phase-bound proteins.
<title>Video indexing application based on watermarking using turbocode and side information</title> (2003)

The aim of this paper is to present a technique to hide data in digital video based on a watermarking approach. The algorithm exploits the side information in the embedding phase; it uses error-correcting codes to improve the achievable robustness and different spatial and temporal masking function to hide the watermark. The watermarking approach is based on an algorithm working in the uncompressed video domain in order to reduce the computational cost. The proposed scheme has been implemented and tested under different attacks, in particular compression and transcoding attacks. The results show that side information and error correcting codes strongly improve the robustness.
Lightning: Utility-Driven Anonymization of High-Dimensional Data (2016)

The ARX Data Anonymization Tool is a software for privacy-preserving microdata publishing. It implements methods of statistical disclosure control and supports a wide variety of privacy models, which are used to specify disclosure risk thresholds. Data is mainly transformed with a combination of two methods: 1 global recoding with full-domain generalization of attribute values followed by 2 local recoding with record suppression. Within this transformation model, given a dataset with low dimensionality, it is feasible to compute an optimal solution with minimal loss of data quality. However, combinatorial complexity renders this approach impracticable for high-dimensional data. In this article, we describe the Lightning algorithm, a simple, yet effective, utility-driven heuristic search strategy which we have implemented in ARX for anonymizing high-dimensional datasets. Our work improves upon existing methods because it is not tailored towards specific models for measuring disclosure risks and data utility. We have performed an extensive experimental evaluation in which we have compared our approach to state-of-the-art heuristic algorithms and a globally-optimal search algorithm. In this process, we have used several real-world datasets, different models for measuring data utility and a wide variety of privacy models. The results show that our method outperforms previous approaches in terms output quality, even when using k-anonymity, which is the model for which previous work has been designed.
Ambient Networks: A Framework for Future Wireless Internetworking (2005)

An increasingly wireless world faces new challenges due to the dynamicity of interactions, range of applications, multitude of available radio access technologies and network functionality. The ambient networks project recognizes these trends and enables the creation of innovative network solutions for mobile and wireless systems beyond 3G. These networks enables scalable and affordable wireless networking while providing pervasive, rich and easy-to-use communication. A specific focus lies on enabling advanced capabilities in environments with increased competition as well as cooperation, environments that are populated by a multitude of user devices, wireless technologies, network operators and business actors. The project adopts a modular architecture that enables plug-and-play control extensibility that supports a wide range of different applications and network technologies. Based on a small subset of common functionality, this approach supports the dynamic deployment of advanced internetworking capabilities, such as media and context-awareness or multi-radio access.
Lectin Binding Characteristics of Several Entomogenous Hyphomycetes: Possible Relationship to Insect Hemagglutinins (1986)

The hyphomycetous insect pathogens Nomuraea rileyi, Paecilomyees farinosus, Metarhizium anisopliae and Beauveria bassiana were tested with fluorescein isothiocyanate (FITC)-labeled lectins in order to determine cell surface sugars. Concanavalin A, specific for glucose and mannose residues, bound to cell surfaces (hyphal body and/or mycelium) of all fungi examined. Soybean and wheat germ agglutinins (affinities for N-acetylgalactosamine and N-acetylglucosamine, respectively) bound inconsistently to some cell surface areas. Peanut agglutinin, specific for galactose residues, bound to walls of only P. farinosus and B. bassiana. Fungal surface sugar residues may be important with respect to insect defense mechanisms against invading cells. Lectins produced by insects (e.g. Anticarsia gemmatalis and Spodoptera exigua) are known to be specifically inhibited by galactose (or higher concentrations of glucose or mannose). Fungal cells (P. farinosus, B. bassiana) which have exposed galactose residues as detected by FITC-peanut agglutinin appear to be especially efficient in removing hemagglutinin activity from A. gemmatalis and S. exigua hemolymph indicating adsorption of the hemagglutinins to fungal surfaces. Such adsorption may render the fungal cells more susceptible to phagocytosis or other insect defense mechanisms.
Programmable Soft-Matter Electronics (2021)

The hydrogels of the polyelectrolytes polyethylenimine and poly(acrylic acid) are used to form a thin-layer interface on the gallium-indium eutectic alloy's surface. The proposed method of gradually increasing the applied voltage reveals the possibility of formation of electronic components: diode, capacitor, resistor, and memristor. The components can be changed to each other many times. A multilayer perceptron model with one hidden layer and 12 nodes allows identifying hydrogels' composition and automatically setting the desired architecture of electronic components. The design of electronic components makes it possible to easy-to-produce new electronic parts and programmable soft-matter electronics.
Renormalization constants for scalar, pseudoscalar, and tensor currents (1975)

We calculate the renormalization constants describing nucleon and pion matrix elements of scalar, pseudoscalar, and tensor ($S, P, T$) current densities. For certain of the constants, expressions can be obtained using standard S${\mathrm{U}}_{3}$ and chiral S${\mathrm{U}}^{3}$\ensuremath{\bigotimes}S${\mathrm{U}}^{3}$ methods. To get the remaining constants, we employ the quark model with spherically symmetric quark wave functions to relate the $S$, $P$, $T$ renormalization constants to known parameters of the usual vector and axial-vector ($V,A$) currents. We also evaluate the renormalization constants using the MIT "bag" model quark wave functions. We summarize our results in tabular form, compare the results of the various calculational methods used, and attempt to estimate the accuracy of our predictions.
A Review of Cosmetic and Personal Care Products: Halal Perspective and Detection of Ingredient (2013)

The term halal refers to what ispermitted by Islamic law. It is a basic need for Muslims and encompasses all materials used in everyday life including cosmetics.Muslims want to be assured that the ingredients,handling, processing, distribution, transportation and types of cosmetic used are halal compliant. The halalaspects of cosmetic and personal care products cover ingredients, all the processes involved in production right up to delivery to consumers, safety and product efficacy evaluations. In order to verify halal compliance of cosmetic products, a method of detecting halal and non-halal ingredients is very important and critically needed. Halal cosmetic standards, halal certification and the halal logo can be used as benchmarks for halal compliance. In view of the importance of cosmetic and personal care products from the halal perspective, this review will cover the halal principles, halal cosmetic and personal care products, ingredients, standard and certification as well as safety. The development of the process of detecting non-halal ingredients and authenticating halal ingredients for potential cosmetic applications in recent years are included in this paper.
Three-dimensional analysis of the mode properties of stripe-geometry D.H.lasers (1979)

The 3-dimensional waveguide problem for stripe-geometry D.H. lasers is solved by an iterative method. The method allows one to self consistently determine the effective dielectric constant. Self-consistent solutions for stripe lasers with symmetric Epstein profiles in the junction plane are compared with approximate solutions obtained by ignoring the influence of the lateral waveguide on the solution of the transversewaveguide problem. It is shown that the approximate method, used previously, can lead to a considerable overestimation of the near-field half width of the fundamental lateral mode.
ChemInform Abstract: Asymmetric C‐N Bond Constructions via Crotylsilane Addition Reactions: A Stereocontrolled Route to Dipeptide Isosteres. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A 28-nm CMOS 7-GS/s 6-bit DAC With DfT Clock and Memory Reaching SFDR >50 dB Up to 1 GHz (2014)

This brief presents a 7-GS/s 6-bit current-steering digital-to-analog converter (DAC) in 28-nm CMOS for VLSI System On Chip I/O embedding with an on-chip memory and clock generation circuits for wafer-sort testing. It demonstrates how Spurious Free Dynamic Range >50 dB can be maintained up to 1 GHz, while keeping the DAC footprint small -0.035 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Several linearization techniques, such as current source cascodes with local biasing, thick-oxide output cascodes, bleeding currents, and 50% level of segmentation are validated for the first time at such very high frequencies. Testing is facilitated by means of integrating a digital front-end design-for-test scheme in 0.048 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . It uses a 5-kb 8X TI data memory, based on circular shift registers to avoid signal-dependent disturbances. An integrated 7-GHz Current Mode Logic ring oscillator-type clock generator and a serial data interface enable simple testing of the DAC at reduced cost.
North American Dictynid Spiders: the Bennetti Group of Amaurobius (1947)

This group of spiders, here designated as the bennetti group of Amaurobius, comprises those North American species which group around Amaurobius bennetti (Blackwall). In these species, the epigynum has a pair of large lateral lobes which converge posteriorly around a small ovoid median lobe. The male has three distinct spurs on the tibia of the palpus, at the distal end above. The more detailed characteristics of this group are as follows:
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates. (1980)

Ternary complex formation of thymidylate synthase (5,10-methylenetetrahydrofolated:dUMP C-methyltransferase, EC 2.1.1.45), 5-fluorodeoxyuridylate (FdUMP), and poly(gamma-glutamyl) conjugates of pteroate and methotrexate (MTX) has been examined as a basis for the sequence-dependent synergism of the 5-fluorouracil-MTX combination in inhibiting viability of L1210 murine tumor cells. A 1.4-log (25-fold) increase in the inhibition of soft agar colony formation was observed when MTX preceded 5-fluorouracil as compared to the reverse sequence. L1210 cells converted 39% of the total intracellular MTX into MTX poly(gamma-glutamate)s within 4 hr of exposure to 1 microM MTX. MTX and MTX(gamma-glutamate) formed reversible ternary complexes with FdUMP on one site of thymidylate synthase, whereas with 7,8-dihydropteroylpentaglutamate and I-5,10-methylenetetrahydropteroylpentaglutamate stoichiometric binding of FdUMP to two sites on thymidylate synthase was observed. The dissociation constants for FdUMP in the ternary complexes formed in the presence of MTX, MTX(gamma-glutamate), 7,8-dihydropteroylpentaglutamate, and I-5-10-methylenetetrahydropteroylpentaglutamate were estimated to be 370, 27, < 10, and < 10 nM, respectively, by equilibrium dialysis. We propose that the sequence-dependent effect of MTX plus 5-fluorouracil on L1210 cell viability results from MTX and MTX polyglutamate inhibition of dihydrofolate reductase (tetrahydrofolate dehydrogenase; 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3) and consequently a trapping of intracellular folates as dihydropteroylpolyglutamates, which increase the extent of FdUMP binding to thymidylate synthase.
Mechanically Responsive Antibacterial Plasma Polymer Coatings for Textile Biomaterials (2013)

We have developed a new type of mechanically responsive material on the basis of a plasma-modified soft biomaterial substrate (polypropylene surgical mesh). A first plasma deposited layer, enriched in a bioactive agent (silver nanoparticles), has been covered by a second plasma polymer layer that acts as a barrier to spontaneous release. The release of the active agent in a controlled manner was achieved by the presence of mechanically reversible fragmentations in the top-layer of deposited plasma polymer, induced by mechanical stimuli. Characterization of the material was performed by Scanning Electron Microscopy, Transmission Electron Microscopy, Attenuated Total Reflexion–Fourier Transform Infra-Red, X-ray Photoelectron, and Ultra Violet–Visible Spectroscopies. The antibacterial properties of the material have been verified.
Enhanced sensitivity of time-resolved reflectivity measurements near Brewster's angle (1989)

A method for enhancing the sensitivity of time-resolved reflectivity measurements in semiconductors is discussed. By appropriate choice of the angle of incidence near Brewster's angle, the photoinduced reflectivity changes are easily increased by one order of magnitude. Two examples, the lifetime of a dense electron-hole plasma and the picosecond laser-induced melting transition in silicon, illustrate the method. Extension to the case of thin films is possible, as demonstrated by experiments performed on thin polycrystalline silicon films. Possible complications due to the use of very tightly focused beams and ultrashort pulses near a strong resonance are considered and, together with other considerations of a more experimental nature, lead to general guidelines for signal-enhancement and easy implementation and data analysis.
A model for particle formation and growth in the atmosphere with molecular resolution in size (2003)

Abstract. The formation and growth of atmospheric aerosol particles is considered using an exact discrete method with molecular resolution in size space. The method is immune to numerical diffusion problems that are a nuisance for typical simulation methods using a sectional representation for the particle size distribution. For condensational growth, a slight modification is proposed for the Fuchs-Sutugin expression, which improves the prediction of the growth rate of nano-sized particles by as much as a factor of two. The presented method is applied to particle formation in a Finnish Boreal forest and is shown to capture the essential features of the dynamics quite nicely. Furthermore, it is shown that the growth of the particles is roughly linear, which means that the amount of condensable vapour is constant (of the order 1013 1/m3).
Encephalopathy associated with cryoprecipitable Australia antigen (1977)

Abstract A 19‐year‐old white woman with urticaria, arthralgias, and hepatitis B–associated antigen in her serum developed a progressive encephalopathy despite only mild hepatic dysfunction. The patient's serum at 4°C produced a cryoprecipitate containing the hepatitis B–associated antigen and its antibody. Serum complement levels were borderline low. At autopsy, gross and histological examination of the brain revealed only mild residual cerebral edema. Indirect immunofluorescent studies of the cerebral cortex and choroid plexus showed no evidence of immune complex deposition. The patient's progressive encephalopathy may have been related to the presence of cryoprecipitable hepatitis B antigen, a relationship not previously reported.
COMPARATIVE STUDY BETWEEN RIGHT VENTRICULAR OUTFLOW TRACT AND RIGHT VENTRICULAR APEX PACING ON CARDIAC FUNCTION (2012)

Objectives To evaluate cardiac function change in patients using the right ventricular outflow tract and right ventricular apex pacing. Methods 119 patients with bradyarrhythmias in our hospital were consecutive selected, cardiac pacemaker implantation are in line with class one indications. exclude, chronic atrial fibrillation, cardiac function three or four grade (NYHA), acute coronary syndrome and other serious medical diseases. And 60 patients randomly selected for right ventricular outflow tract pacing (DDD), (group A). 59 cases (group B), selected for right ventricular apex pacing in. Both groups were no significant difference with age, gender, type of arrhythmia, heart function. Results The two groups according to the cumulative percent ventricular pacing (cum% VP >50% <100%, 42 cases in group A, 38 cases in group B, between the two groups was not statistically significant; but the left ventricular ejection fraction (LVEF) in group A higher than in group B, and B-type natriuretic peptide (BNP) decreased in group A compare with group B (p<0.05). Group A after 18 months compared with preoperative LVEF has a certain degree increased, BNP decreased (p>0.05), group B after 18 months compared with preoperative LVEF slightly lower, with a certain degree of increased BNP (p>0.05). Conclusions Right ventricular outflow tract pacing can improve heart function compared with right ventricular apex pacing, and to some extent improve heart function compared with preoperative too.
Measurement of dispersion in a silicon waveguide at 1.5 μm (2002)

We report for the first time measurements of the dispersion coefficient in a silicon waveguide at 1.5 /spl mu/m wavelength. The total dispersion was found to be only -9.1 fs/[nm.cm].
FY11 Financial and Operational Survey of Major University Nanofabrication Facilities (2012)

The primary intent of this survey is to provide all interested parties (researchers, management, users, administration, and support staff) with a well-vetted updated set of data upon which a constructive discourse may be established regarding operational costs, tool rates, staffing, safety, and basic efficiency guidelines of a complex nanofabrication facility. Secondarily, the authors also aim to establish a set of data by which the stakeholders may evaluate the total cost of research, not just the cost of the laboratory, ranging from lab fees to tuition to indirect cost policies to student stipend.
Probing entropic repulsion through mesoscopic simulations (2017)

Following the publication of Freund's work on entropic pressure (Freund L., Proc. Natl. Acad. Sci. U.S.A., 110 (2013) 2047), which states that the undulation pressure for a biomembrane confined between two parallel rigid walls decays linearly with wall separation (d), different contradictory views on the pressure law evolved; some supporting Helfrich's prediction that the entropic pressure scales as . Attempts were made to resolve this stark contradiction by distinct groups of researchers. In this work, using dissipative particle dynamics simulations it has been shown for the first time that the height fluctuations are suppressed by wall confinement. An analysis of the fluctuation spectrum reveals that the entropic loss manifests as a membrane tension for a membrane that conserves its local area, and this fact is confirmed by the rise in stresses with an increase in wall confinement. Furthermore, we theorize a pressure law, which interestingly is congruous with Freund's prediction that the entropic pressure scales as .
THE EFFECTOF ENTRAPPEDKRYPTON85 GASON DEVICERELIABILITY (1983)

The effectof entrappedKr85radioactive gas upon the thresholdvoltageand junction leakage of MOS transistorsis quantified throughdevicemodelingand acceleratedtesting. The interactionsof transistorchannel length,channelwidth,oxidethickness,radiation level,and exposure time are experimentallydetermined.A mathematicalmodelis developedwhich predictsthresholdvoltage shifts as a functionof these processing variablesand the amountof entrappedKr gas. This modelis usedto establish,froma reliability9standpoint, acceptablelevelsof entrappedKr8 for currentand new generation devices.