gebhart/patrepeval huggingface dataset:
Design considerations of multi-layer piezoelectric transformers (2002)

Piezoelectric transformers (PTs) present an attractive solution compared with magnetic transformers because they have alternative characteristics that are appropriate for particular applications, namely high power density and high isolation levels with low EMI content. The behavior of PTs is very dependent on the material type, geometry and number of layers. Since PTs should be used in a power topology, it is necessary to establish design rules in order to select the proper specifications of the PT for each particular application. This work presents some design guidelines as well as the description of the influence of several constructive parameters on the behavior of the multi-layer PTs.
CO Dissociation at Elevated Pressures on Supported Pd Nanoclusters (2004)

In-situ polarization modulation infrared reflection absorption spectroscopy (PM-IRAS) is used to study CO adsorption at elevated pressures and temperatures on Pd nanoclusters deposited on crystalline SiO2 thin films. The PM-IRAS data indicate that CO dissociates on the Pd nanoclusters at 185 mbar and at temperature >600 K. Combined STM and PM-IRAS data show that the Pd nanoclusters are three-dimensional and consist predominantly of 〈111〉 facets with an average diameter and height of 3.5 and 0.7 nm, respectively. STM data indicate no change in the morphology or sintering of the Pd nanoclusters between 300 and 650 K. For comparison, CO adsorption was investigated on a Pd(111) single-crystal surface using PM-IRAS under similar conditions (PCO = 133 mbar, T = 175−750 K). Comparison of the PM-IRAS data for CO adsorption on Pd(111) and Pd nanoclusters indicate that in contrast to the Pd nanoclusters, CO adsorbs molecularly on the Pd(111) surface in a reversible manner, i.e., no dissociation.
Studies toward the Synthesis of Potent Anti-inflammatory Peptides Solomonamides A and B: Synthesis of a Macrocyclic Skeleton and Key Fragment 4-Amino-6-(2′-amino-4′-hydroxyphenyl)-3-hydroxy-2-methyl-6-oxohexanoic Acid (AHMOA) (2012)

A first synthetic effort toward total synthesis of highly potent solomonamides is disclosed. An efficient strategy to synthesize this class of compounds, along with the synthesis of a core macrocycle (shown in red) and the key fragment AHMOA, is described.
Additional strategies for improving sensitivity and reliability of immunoassay (1994)

Journal Article Additional strategies for improving sensitivity and reliability of immunoassay Get access R M Carter, R M Carter Search for other works by this author on: Oxford Academic Google Scholar G G Guilbault, G G Guilbault Search for other works by this author on: Oxford Academic Google Scholar G J Lubrano, G J Lubrano Search for other works by this author on: Oxford Academic Google Scholar M B Jacobs M B Jacobs Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 40, Issue 10, 1 October 1994, Pages 1986–1987, https://doi.org/10.1093/clinchem/40.10.1986 Published: 01 October 1994
ChemInform Abstract: Causes of Unreproducibility of C. rugosa Lipase‐Catalyzed Reactions in Slightly Hydrated Organic Media. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Changes to the Editorial Board (2017)

Prof. Jurriaan Schmitz has decided to step down from the editorial board. On behalf of IEEE Electron Device Letters staff and readers, I would like to express appreciation for his diligent service to the journal over the past five years.
Parametric modeling of diverse antennas designed for IR and MB-OFDM UWB systems (2008)

This paper presents and compares the parametric modeling of several types of antennas designed for IR (Impulse Radio) and MB-OFDM (Multi-Band Orthogonal Frequency Division Multiplexing) UWB systems. Parametric models, based on the singularity expansion method, are computed in order to model the transfer functions and the impulse responses of antennas. Thus, the complexity and the accuracy of time/frequency models of diverse UWB antennas are analyzed.
F-1117 Impact Tensile Behavior of Liquid Packaging Bag (2001)

Since laminate films used for liquid packaging bags are produced by laminating very thin single films, they are easily influenced by atmospheric temperature; bags often break due to impact load during loading and unloading of packaged products. In this study, impact tensile tests were carried out at relatively low impact tensile speeds between v=0.20 and 1.40 m/s using a rotary impact tensile apparatus developed by us, with atmospheric temperature varied to six temperatures, i.e., t=0, 10, 20, 30, 40 and 50℃. The results indicate that the impact tensile strength of NY/EVA is negligibly influenced by the impact tensile speed at an atmospheric temperature of t=50℃, while those of NY/XA and PET/XA are influenced by the impact tensile speed.
Nanoscale analysis of caspofungin-induced cell surface remodelling in Candida albicans (2012)

The advent of fungal pathogens that are resistant to the classic repertoire of antifungal drugs has increased the need for new therapeutic agents. A prominent example of such a novel compound is caspofungin, known to alter cell wall biogenesis by inhibiting β-1,3-D-glucan synthesis. Although much progress has been made in understanding the mechanism of action of caspofungin, little is known about its influence on the biophysical properties of the fungal cells. Here, we use atomic force microscopy (AFM) to demonstrate that caspofungin induces major remodelling of the cell surface properties of Candida albicans. Caspofungin causes major morphological and structural alterations of the cells, which correlate with a decrease of the cell wall mechanical strength. Moreover, we find that the drug induces the massive exposure of the cell adhesion protein Als1 on the cell surface and leads to increased cell surface hydrophobicity, two features that trigger cell aggregation. This behaviour is not observed in yeast species lacking Als1, demonstrating the key role that the protein plays in determining the aggregation phenotype of C. albicans. The results show that AFM opens up new avenues for understanding the molecular bases of microbe-drug interactions and for developing new therapeutic agents.
First Intramolecular Enantioselective Iridium‐Catalyzed Allylic Aminations. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma (1997)

Serum ferritin is elevated in many cancers. Using the subtraction-enhanced display technique, we isolated several cDNA clones including ferritin-H which is overexpressed in rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine. We investigated hepatic messenger RNA (mRNA) levels of ferritin-H in patients with HCC, adenoma, cirrhosis and healthy controls in relation to those of oncogene c-myc. Ferritin-H mRNA levels were 2-12 fold higher in tumor tissues than in adjacent non-tumor tissues in 12 of 17 patients with HCC, irrespective of coexisting cirrhosis or viral hepatitis. However, no difference in ferritin-H mRNA levels was found in patients with adenoma, cirrhosis and healthy controls. c-myc mRNA levels were 2-5 ford increased in 11 of 17 HCC patients, and correlated significantly with those of ferritin-H (p<0.001). In situ hybridization showed that the overexpressed ferritin-H mRNA was restricted to the tumor nodules in HCC livers. These findings suggest that overexpression of ferritin-fl in HCC patients, correlated with c-myc, is phenotypically associated with HCC, and could become a useful molecular indicator for human HCC.
Excited States of the 5-Chlorophyll Photosystem II Reaction Center (1999)

Results of 4.2 K hole burning, chemical reduction (sodium dithionite, in dark and with illumination), and oxidation (ferricyanide) experiments are reported for the isolated PS II reaction center containing five chlorophyll (Chl) molecules (RC-5). Qy states at 679.6 and 668.3 nm are identified as being highly localized on pheophytin a of the D1 branch (Pheo1) and pheophytin a of the D2 branch (Pheo2), respectively. The Pheo1−Qx and Pheo2−Qx transitions were found to lie on the low and high energy sides of the single Pheo−Qx absorption band, at 544.4 and 541.2 nm, respectively. The Qy band of the 684 nm absorbing Chl, which is more apparent in absorption in RC-5 than in RC-6 samples, is assigned to the peripheral Chl on the D1 side. The results are consistent with that peripheral Chl being Chlz (Stewart, D. H.; Cua, A.; Chisholm, D. A.; Diner, B. A.; Bocian, D. F.; Brudvig, G. W. Biochemistry 1998, 37, 10040). The results indicate that P680, the primary electron donor, is the main acceptor for energy transfer from the Pheo1−Qy state and that excitation energy transfer from the Pheo1−Qy state and P680* to the 684 nm Chl is inefficient. It is concluded that the procedure used to prepare RC-5 has only a small effect on the energies of the Qy states associated with the core cofactors of the 6-Chl RC as well as the 684 nm Chl. Implications of the results for the multimer model (Durrant, J. R.; Klug, D. R; Kwa, S. L. S.; van Grondelle, R.; Porter, G.; Dekker, J. P. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 4798) are considered. In that model the Qy-states of the core are significantly delocalized over several cofactors. The results presented provide no support for this model.
Auto-Correlation Vocoder (1960)

In an auto-correlation vocoder system, samples of the short-time auto-correlation function of a speech signal are transmitted over a reduced bandwidth channel and converted into a time wave that is properly periodic and a replica of the auto-correlation function. By Wiener's theorem, the amplitude spectrum of the thus synthesized signal is the power spectrum of the analyzed speech signal. Phenomenologically, this spectrum squaring has four distinct effects: 1. Doubling of dynamic level fluctuations. 2. Doubling of formant level differences. 3. Deepening of spectral minima (“zeros”). 4 Reduction of formant bandwidths. The most serious of these spectral degradations have been removed by a variable equalizer preceding the auto-correlation analyzer. The remade speech quality produced by this technique exceeds that of known frequency-channel vocoders and of a previously described cross-correlation vocoder [J. Acoust. Soc. Am. 31, 852 (A) (1959)]. Bandwidth (or time) compression is about 10:1 (before multiplexing). Tape-recorded speech samples from the equalized auto-correlation vocoder will be played.
Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in <i>SPTLC2</i> (2013)

This study confirms that mutations in SPTLC2 are associated with increased deoxySL formation causing HSANI.
Growth Mechanisms in Germanium Dendrites: Three Twin Dendrites; Experiments on and Models for the Entire Interface (1963)

The measured growth velocity of three twin germanium dendrites has been related to melt undercooling and to one of the twin spacings, and can be explained by the theory for two twin dendrites of this spacing. Three twin dendrites differed from two twin dendrites in that they grew at lower undercoolings, and, when propagation was possible, grew as fast or faster in the reverse or [2̄11] directions as in forward or [21̄1̄]'s. Irrespective of twin structure, the theory of Horvay and Cahn fitted parabolic decanted interfaces, provided the undercooling was taken to be that apparent at the tip and not that of the melt. Calculations from a model show layer nucleation to be possible on part of the interface and provide a rational for the understanding of H-arm growth. The spacing of certain facets is found to agree moderately well with predictions of the theory of Mullins and Sekerka on morphological instabilities.
The R‐factors of multiple antibiotic resistant faecal coliforms isolated from a domestic dog (1983)

The antibiotic resistant faecal flora of a domestic dog suffering from an acute enteric infection was examined. The flora exhibited overall resistance to a wide variety of antibiotics. However, following restoration of the animal to normal health, overall resistance to ampicillin (Ap), tetracycline (Tc), chloramphenicol (Cm) and streptomycin Sm was lost, although low numbers of bacteria resistant to these four antimicrobial agents could still be isolated up to one year later. A total of 11 strains were purified for further study. All 11 were positively identified as Escherichia coli and shown to be resistant to various combinations of the above antibiotics, and additionally to kanamycin (Km). Each strain harboured from one to five plasmids, although only four proved capable of transferring antibiotic resistance to Escherichia coli K-12. One of the strains was found to harbour two conjugal plasmids pNJ101 (60 Md) and pNJ102 (133 Md) which coded for resistance to Cm, Tc, Ap and Cm, Tc, Km respectively. A third plasmid pNJ103 (29 Md) remains cryptic. The possession of the two plasmids pNJ101 and pNJ102 appears to be an unstable situation as variants arose harbouring one or other of the plasmids.
Tobamovirus Vectors for Expression of Recombinant Genes in Plants (1998)

Plant and animal RNA viruses are increasingly used for gene delivery and expression in a variety of host cells. At a molecular level these agents can be viewed as cytosolic parasites of the ribosome, successfully competing for translation with the host messenger RNA (mRNA) population. In many virus-infected plants, modified plasmodesmata between adjacent cells enable movement of progeny virus throughout the whole organism. Because of this unique virus-host interaction, crop plants provide an inexpensive source of biomass available for rapid genetic manipulations.
Leukocyte esterase and protein levels in saliva, as indicators of gingival and periodontal diseases in children. (2004)

Dip stick protein analysis of saliva of children has the potential to differentiate children with periodontitis or with fewer periodontal lesions.
SILICONE BREAST IMPLANTS AND FIBROMYALGIA (2001)

12901 Bruce B. Downs Boulevard MDC Box 81 Tampa, Fla. 33612-4799 Charles R. Mills, M.D. Alvin F. Wells, M.D.
Dynamic UV microstereolithography (2002)

A new process of microstereolithography to manufacture freeform solid three-dimensional micro-components with outer dimensions in the millimetre size range is presented. The process, based on the use of a liquid crystal display as a dynamic mask generator, works with conventional industrial UV-sensitive stereolithographic materials. The main innovation of the process consists in using the optical frequency up-conversion of images from the visible to the UV range in order to overcome the opacity of LCD's in the UV domain. 400 × 400 points up-converted images have been obtained to generate solid three-dimensional objects.
Ultraviolet excitation of cryogenic rare-gas chlorine solutions (1985)

The properties of dimer and trimer emissions following optical excitation of cryogenic rare-gas chlorine solutions—Kr(Cl2), Xe(Cl2), Ar(Kr, Cl2), Ar(Xe, Cl2), and Kr(Xe, Cl2)—at 351, 248, and 193 nm are reported. Fluorescences corresponding to dimer XeCl*(C3/2 → A3/2) and trimer (Kr2Cl*, KrXeCl*, Xe2Cl*) transitions are detected.
Nitric oxide and asymmetric dimethylarginine (ADMA) in malignancy associated thrombosis and their modulation by anticoagulants (2006)

10573 Background: Cancer associated thrombotic complications are primarily due to endothelial dysfunction and upregulation of inflammatory processes. Nitric oxide (NO) represents one of the major endothelial derived vasoactive mediators. Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of NO synthase which inhibits NO production at pathophysiologic levels. Plasma ADMA levels are upregulated in atherosclerosis, hypertension, end stage renal disease, chronic heart failure and microangiopathy. Methods: To test the hypothesis that endothelial dysfunction in cancer patients may result in increased ADMA levels, plasma samples were retrospectively analyzed from an open label, multidose, active comparator designed study in which all patients (n = 110) were initially treated with low molecular weight heparin, enoxaparin (E) at 1–1.5 mg/kg sc for 5 days and further subdivided into group E which continued to receive E and warfarin (W) group which was given oral anticoagulants for a period of up to 12 weeks. Baseline blood samples (BL), 5 days post E (IPE) and 4–6 week samples from the E and W were analyzed for ADMA and NO levels by ELISA methods. Results: Both the ADMA and NO levels were markedly elevated in cancer patients. The E treated group showed a marked decrease in the ADMA levels which persisted throughout the treatment period. However, in the W converted group the ADMA levels rebounded to an increased level indicating that E differentially regulated ADMA in these patients. The down regulation pattern of NO was similar for both E and W. Conclusions: These results suggest that patients with cancer and thrombosis exhibit simultaneous upregulation of ADMA and NO. While E and W show a differential regulation of ADMA both result in downregulation of NO. The fact that E regulates ADMA is highly suggestive of its role in iNOS regulation which may be involved in the inflammatory response in cancer patients. [Table: see text] No significant financial relationships to disclose.
Characterization of L-Histidine Ammonia-lyase Immobilized by Microencapsulation in Artificial Cells: Preparation, Kinetics, Stability, and in Vitro Depletion of Histidine (1990)

L-histidine ammonia-lyase (histidase) was encapsulated within cellulose nitrate artificial cells, and its kinetic parameters were evaluated. Microencapsulated histidase had an apparent activity of histidase in solution. Encapsulation did not alter the Km of histidase. The Km of histidase solution and the Km apparent of micro-encapsulated histidase were both 20 mM. Encapsulation of histidase resulted in increased stability of enzymatic activity at storage temperatures of 4 degrees C and 37 degrees C. At 37 degrees C histidase solution reached 50% of its original activity after 9.5 days of storage, while microencapsulated histidase reached the same level after 15 days. At 4 degrees C histidase solution had 63% of its original activity after 21 days of storage, while encapsulated histidase had 95%. In vitro experiments to evaluate the feasibility of microencapsulated histidase for possible experimental therapy in histidinemia were carried out. These experiments evaluated the effectiveness of encapsulated histidase in depleting histidine. Three different volume ratios of histidase loaded artificial cells to substrate solution were tested. A ratio of 1: 100 allowed 25% histidine depletion after 120 hours. A 1: 50 ratio allowed 35% histidine depletion after 72 hours. A 1: 25 ratio allowed 40% histidine depletion after 24 hours (Int J Artif Organs 1990; 13: 189-95).
T Cell-Independent, TLR-Induced IL-12p70 Production in Primary Human Monocytes (2006)

IL-12p70 is a key cytokine for the induction of Th1 immune responses. IL-12p70 production in myeloid cells is thought to be strictly controlled by T cell help. In this work we demonstrate that primary human monocytes can produce IL-12p70 in the absence of T cell help. We show that human monocytes express TLR4 and TLR8 but lack TLR3 and TLR7 even after preincubation with type I IFN. Simultaneous stimulation of TLR4 and TLR8 induced IL-12p70 in primary human monocytes. IL-12p70 production in peripheral blood myeloid dendritic cells required combined stimulation of TLR7/8 ligands together with TLR4 or with TLR3 ligands. In the presence of T cell-derived IL-4, but not IFN-gamma, stimulation with TLR7/8 ligands was sufficient to stimulate IL-12p70 production. In monocytes, type I IFN was required but not sufficient to costimulate IL-12p70 induction by TLR8 ligation. Furthermore, TLR8 ligation inhibited LPS-induced IL-10 in monocytes, and LPS alone gained the ability to stimulate IL-12p70 in monocytes when the IL-10 receptor was blocked. Together, these results demonstrate that monocytes are licensed to synthesize IL-12p70 through type I IFN provided via the Toll/IL-1R domain-containing adaptor inducing IFN-beta pathway and the inhibition of IL-10, both provided by combined stimulation with TLR4 and TLR8 ligands, triggering a potent Th1 response before T cell help is established.
Managing changes with legacy security engineering processes (2011)

Managing changes in Security Engineering is a difficult task: the analyst must keep the consistency between security knowledge such as assets, attacks and treatments to stakeholders' goals and security requirements. Research-wise the usual solution is an integrated methodology in which risk, security requirements and architectural solutions are addressed within the same tooling environment and changes can be easily propagated. This solution cannot work in practice as the steps of security engineering process requires to use artefacts (documents, models, data bases) and manipulate tools that are disjoint and cannot be fully integrated for a variety of reasons (separate engineering domains, outsourcing, confidentiality, etc.). We call such processes legacy security engineering processes. In this paper, we propose a change management framework for legacy security engineering processes. The key idea is to separate concerns between the requirements, risk and architectural domains while keeping an orchestrated view (as opposed to an integrated view). We identify some mapping concepts among the domains so that little knowledge is required from the requirement manager about the other domains, and similarly for security risk manager and the system designer: they can stick to their well known (and possibly certified) internal process. This minimal set of concepts is the interface between the legacy processes. The processes are then orchestrated in the sense that when a change affects a concept of the interface, the change is propagated to the other domain. We illustrate this example by using the risk modeling language (Security DSML) from Thales Research and the security requirement language (SI*) from the Univ. of Trento.
Influence of Aggregate Type and Size on Ductility and Mechanical Properties of Engineered Cementitious Composites (2009)

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