gebhart/patrepeval huggingface dataset:
The Ubiquitin-Conjugating Enzyme UBCH7 Acts as a Coactivator for Steroid Hormone Receptors (2004)

We investigated the role of the ubiquitin-conjugating enzyme UBCH7 in nuclear receptor transactivation. Using transient transfection assays, we demonstrated that UBCH7 modulates the transcriptional activity of progesterone receptor (PR) and glucocorticoid, androgen, and retinoic acid receptors in a hormone-dependent manner and that the ubiquitin conjugation activity of UBCH7 is required for its ability to potentiate transactivation by steroid hormone receptors (SHR). However, UBCH7 showed no significant effect on the transactivation functions of p53 and VP-16 activation domain. Depletion of endogenous UBCH7 protein by small interfering RNAs suggests that UBCH7 is required for the proper function of SHR. Furthermore, a chromatin immunoprecipitation assay demonstrated the hormone-dependent recruitment of UBCH7 onto estrogen receptor- and PR-responsive promoters. Additionally, we show that UBCH7 and E6-associated protein (E6-AP) synergistically enhance PR transactivation. We also demonstrate that UBCH7 interacts with steroid receptor coactivator 1 (SRC-1) and that UBCH7 coactivation function is dependent on SRC-1. Taken together, our results reveal the possible role of UBCH7 in steroid receptor transactivation and provide insights into the mechanism of action of UBCH7 in receptor function.
A frequency agile X-band homodyne GaAs MMIC transceiver with a synthesized phase locked source for automotive collision avoidance radar (2002)

A frequency agile X-band homodyne transceiver system with a synthesized phase locked source has been developed as a cost effective solution for volume automotive and communications systems applications. A GaAs X-band MMIC transceiver chip and divide-by-four prescaler chip have been designed, fabricated, and tested. The GaAs prescaler converts the X-band oscillator to S-band, where low cost silicon prescaler and phase/frequency detector chips have been used to phase lock the VCO to a 19.660 MHz crystal reference. Transmitted output power is +14.5 dBm with a -60 dBc/Hz phase noise @ 100 kHz offset. On-chip filtering rejects spurious emissions below FCC limits. The receiver noise figure is less than 9 dB with a 2 dB conversion loss and an IF bandwidth of 2 GHz. The entire system fits into a 0.9"/spl times/2.0"/spl times/0.4" form factor utilizing a duroid on glass epoxy (FR-4) board for the interconnect substrate. While the GaAs MMIC transceiver chip was designed for an automotive application, the phase locked frequency source and system are also applicable to next generation data communications systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Micromachined microwave actuator (MIMAC) technology-a new tuning approach for microwave integrated circuits (2002)

The authors describe a novel approach to the realization of tunable/variable III-V planar microwave integrated circuits, which uses micromachined electrostatically controlled actuator technology. This technology is potentially compatible with conventional MMIC (monolithic microwave integrated circuit) fabrication techniques, and allows precise positioning and re-positioning of metal conductors on an insulating substrate after fabrication is complete. A variety of structures has been fabricated, including electrostatic micro-motors, rotating microwave switches, and variable interdigitated capacitors. A rotating microwave transmission line switch exhibited less than 0.5 dB insertion loss and greater than 35 dB isolation from DC to 45 GHz. A variable interdigitated capacitor exhibited a variation from 35 fF to 100 fF.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adipose-Derived Stem Cells Seeded on Acellular Dermal Matrix Grafts Enhance Wound Healing in a Murine Model of a Full-Thickness Defect (2012)

Adipose-derived stem cells seeded on an ADM can enhance wound healing, promote angiogenesis, and contribute to newly formed vasculature, and VEGF-expressing ASCs can be detected after transplantation. This model could be used to improve the other clinical applications of ASCs and to decipher the detailed mechanism by which ASCs interact with wound tissue.
ChemInform Abstract: ANTIIMPLANTATION AGENTS: PART I ‐ 1‐ARYLTHIOSEMICARBAZIDES (1985)

Abstract Über 90 Arylthiosemicarbazone wie (I)‐(III) und ähnliche Strukturen werden nach bekannten Methoden synthetisiert und auf Antifertilitäts‐Wirkung (Maus, Ratte) geprüft.
Three-dimensional analytic model of permanent magnet axial flux machine (1998)

A three-dimensional (3-D) magnetic field problem in an axial flux machine with a toroidal winding is considered. The precise solutions generated by the integral transform and Fourier methods in elementary subregions are joined using the iterative Schwartz algorithm. The comparison between two dimensional and 3-D models is performed and a correction factor taking into account the radial variation of the magnetic flux is given.
On the Magnetic Properties of Cr<sub>2</sub>As and Cu<sub>2</sub>Sb (1960)

The thermomagnetic properties of the compound Cr 2 As and Cu 2 Sb were investigated together with the phase diagram of Cr–As system. From the results of thermal and thermomagnetic measurements for Cr 2 As and Cu 2 Sb it was found that they show antiferromagnetic behavior with the Néel point at 393°K and at 373°K respectively. Their reciprocal susceptibilities obey the Curie-Weiss law in high temperature range, but a considerable deviation therefrom is seen just above the Néel point. From the Curie constant obtained by the present experiment, the effective magneton number µ eff of the magetic carrier was calculated to be 3.6 and 2.6 for these compounds, Cr 2 As and Cu 2 Sb, respectively. The total heat absorptions due to the vanishing of antiferromagnetic order in spin arrangement were 50 Cal/mol and 20 Cal/mol. A discussion is given on the origin of the above-mentioned magnetic properties.
Seamless Handover with Buffer Prediction for Wireless Networks Based on IEEE 802.21 (2008)

Future generations of wireless networks will place great demands on the performance of radio access technology and the real-time multimedia applications provided by these new wireless environments. During the mobility between heterogeneous wireless networks, the quality of multimedia services for users depends heavily on seamless handover which should be provided by the middleware of IP to MAC protocol stack. IEEE 802.21 is designed for this reason which provided the basic platform for seamless handover between heterogeneous wireless networks. In this paper, a dynamically adjusted buffer component with algorithm for prediction of the buffer size is proposed to enhance the functionality of IEEE 802.21. The mechanism of proposed scheme included Service Specific Layer which decides the opportunity of handover, and adjusted Buffer which stores the temporal streaming data for applications between handover. The services and communication flows among service specific layer, buffer and IEEE 802.21 Media Independent Handover function are described and analyzed. According to analysis of the connection process and simulation, buffer prediction and pre-allocation could indeed reduce the influence of handover between heterogeneous wireless networks.
Research on the light source of 60GHz millimeter wave ROF system (2006)

A novel light source is proposed and applied in a 60 GHz millimeter wave Radio-over-Fiber (ROF) system. The Fabry-Perot semiconductor laser diode ( F-P SLD) which shows a multimode output can be converted to a single-mode laser source by employing a F-P SLD locked to the externally injected narrow-band amplified spontaneous emission (ASE). We successfully apply this source in the BS (base station) of 60 GHz millimeter wave ROF system
Appendicitis and Pregnancy (1963)

In 74,000 obstetrical patients at Los Angeles County Hospital the incidence of acute appendicitis in pregnancy was 0.05 per cent. In a study of 36 cases of clinically diagnosed appendicitis in pregnancy between 1956 and 1960, it was shown that the fetal and maternal morbidity and mortality were decreased when a definite operative procedure was done early. The difficulty in diagnosis is increased by the necessary consideration of pyelonephritis and twisted ovarian cyst. Rupture of the appendix increased hazards to maternal and fetal survival. It was noted also that threatened premature labor may indicate a ruptured appendix. Emergency operation with the use of antibiotics in such cases was effective therapy. The incidence of premature delivery was proportionate to the delay in operating. If operation was performed in less than eight hours after admission to the hospital, there was no maternal or fetal loss. A delay greater than eight hours resulted in a 17 per cent fetal loss in premature delivery and 4 per cent fetal loss of infants at term.
Dimethyl Substituted Polyaromatic Alkaline Ionomers for Better Alkaline Hydrogen Oxidation (2018)

Development of new ionomeric binding materials for the fabrication of fuel cell electrode is important to enhance performance and durability of alkaline membrane fuel cells. 1 Recently we reported that adsorption of benzene groups in the polymer electrolytes on Pt-based electrocatalyst may cause an adversary impact on the activity of the hydrogen oxidation reaction under alkaline condition. 2 In order to mitigate such adverse impact and further improve the fuel cell durability, here we report a new design of polyaromatic ionomers with dimethyl substituted aromatic backbone from acid-catalyzed Friedel-Crafts polycondensation 3 using 2,2’-dimethylbiphenyl as a monomer. The backbone of the ionomer does not contain alkaline-labile aryl-ether linkage for chemical durability in high temperature alkaline condition. 4 The hydroxide form of the ionomers with ion exchange capacity of 2.5 meq./g showed good solubility in a wide range of solvents including methanol, ethanol, isopropanol and polar aprotic solvents, which eases the fabrication of materials as electrode binders. The performance of the dimethylated ionomeric binders was tested in membrane electrode assembly using Pt-based catalysts under H 2 /O 2 conditions and compared to that of poly(biphenyl alkylene) without methyl substituents. The membrane electrode assembly using the dimethylated ionomers showed good performance (peak power density up to 600 mW/cm 2 ) with stable short-term stability. In this presentation, further structural effect of the polyaromatic ionomers will be discussed with other critical fuel cell operation factors that link with fuel cell performance. Acknowledgments This work is supported by the US Department of Energy, Energy Efficiency and Renewable Energy, Fuel Cell Technology Office (Program Manager: David Peterson). References Gottesfeld, D. R. Dekel, M. Page, C. Bae, Y. Yan, P. Zelenay, Y. S. Kim. J. Power Sources , doi:10.1016/j.jpowsour.2017.08.010 (2017). Matanovic, H. T. Chung, Y. S. Kim. J. Phys. Chem. Lett. 8 , 4918 (2017). W.H. Lee, Y. S. Kim, and C. Bae. ACS Macro Lett. 4 , 814 (2015). Fujimoto, D. S. Kim, M. Hibbs, D. Wrobleski, Y. S. Kim. J. Memb. Sci. 423 , 438 (2012).
Zeolite Membranes in Catalysis—From Separate Units to Particle Coatings (2015)

Literature on zeolite membranes in catalytic reactions is reviewed and categorized according to membrane location. From this perspective, the classification is as follows: (i) membranes spatially decoupled from the reaction zone; (ii) packed bed membrane reactors; (iii) catalytic membrane reactors and (iv) zeolite capsuled catalyst particles. Each of the resulting four chapters is subdivided by the kind of reactions performed. Over the whole sum of references, the advantage of zeolite membranes in catalytic reactions in terms of conversion, selectivity or yield is evident. Furthermore, zeolite membrane preparation, separation principles as well as basic considerations on membrane reactors are discussed.
An FPGA-Based Linear All-Digital Phase-Locked Loop (2010)

In this paper, an all-digital phase-locked loop (ADPLL) is presented, and it is implemented on a field-programmable gate array. All components like the phase detector (PD), oscillator, and loop filter are realized as digital discrete-time components fed from analog-to-digital converters. The phase detection is realized by generating first an analytic signal using a compact implementation of the Hilbert transform and then computing the instantaneous phase with the CORDIC algorithm. A phase-unwrap component was realized, which extends the linear range of the PD, so that the linear model is valid in the full frequency range. This property leads to a constant lock-in time for arbitrary frequency changes. An analytic solution for the lock-in frequency range and the stability range including processing delays is given. All relations to design an ADPLL of the presented structure are derived. A detailed example application of an ADPLL designed as an offset local oscillator is given.
Physiologic inactivation of fluid phase C3b: isolation and structural analysis of C3c, C3d,g (<i>alpha</i> 2D), and C3g. (1984)

The fragments that result from the inactivation of C3b have not been completely characterized. Initial inactivation is catalyzed by the protease factor I, which, in the presence of its cofactor (factor H), cleaves two peptide bonds in the alpha'-chain of C3b. This results in the release of a small peptide (C3f, Mr 3000) from iC3b, which consists of the C3 beta chain covalently bonded to two alpha'-chain-derived peptides (Mr 68,000 and Mr 43,000). Surface-bound iC3b is cleaved at a third site by factor I to produce C3c and C3d,g (or alpha 2D). The factor I cofactor for this cleavage is the C3b receptor that is present on erythrocyte and leukocyte membranes. This report describes the isolation and initial structural characterization of C3c and C3d,g generated in whole blood after complement activation with cobra venom factor. These fragments were compared with the C3 fragments isolated from the serum and plasma of a patient with complement activation in vivo. The fragments were isolated with two solid phase monoclonal antibodies, one of which recognizes a determinant on C3g (clone 9) and one of which recognizes a determinant on C3c (clone 4). C3c isolated from normal blood showed three polypeptides that had apparent m.w. of 75,000, 43,000, and 27,000. The C3d,g consisted of a single polypeptide chain with a m.w. of 40,000. Amino terminal sequence analysis showed that the Mr 27,000 peptide from C3c is derived from the amino terminal portion of the alpha'-chain of C3b, whereas the Mr 43,000 peptide is derived from the carboxy terminus of the same chain. Amino terminal sequence analysis showed also that C3g is derived from the amino terminus of C3d,g. The C3 fragments isolated from a patient with partial lipodystrophy, nephritic factor activity, low serum C3 levels, and circulating C3 cleavage products showed a more complicated pattern on SDS-PAGE. The fragment isolated with clone 9 had an apparent m.w. of 40,000, identical to C3d,g generated in vitro, and it had the same amino terminal sequence as C3d,g generated in vitro. The eluate from insolubilized clone 4, however, showed prominent bands with Mr of 75,000, 56,000, 43,000, and 27,000, together with a triple-banded pattern at 68,000 and a minor band at 80,000. This eluate thus appears to contain C3c, and iC3b or an iC3b-like product. The origin of the Mr 56,000 and Mr 80,000 peptides have not yet been determined. These studies, with previous data, definitively order the C3c and C3d,g peptides in the alpha-chain of C3.(ABSTRACT TRUNCATED AT 400 WORDS)
In vitro secretion of progestins by rat luteal cells and their 20.ALPHA.-hydroxysteroid dehydrogenase activity. (1986)

Functionally active or regressing corpora lutea were harvested from pseudopregnant (psp) rats between days 5-8 of psp or day 15 of psp, respectively. They were enzymatically dispersed and cultured for 24 h to assess progestins in the medium and 20 alpha-hydroxysteroid dehydrogenase [20 alpha-HSD, catalyzing the conversion of progesterone to 20 alpha-dihydroprogesterone (20 alpha-OH-P)] activity in the cell. Though the active luteal cells retained low 20 alpha-HSD activity, they secreted 6-7 times more 20 alpha-OH-P than progesterone as the regressing luteal cells did. There was no significant difference between the total amounts of progestins in the 2 groups. When increasing doses of pregnenolone were added to the media, progesterone secretion from the active luteal cells was promoted and the progesterone to 20 alpha-OH-P ratio became comparable to the circulating progestins ratio during the mid-luteal phase. In contrast, from the regressing luteal cells only 20 alpha-OH-P secretion was promoted. These results indicate that an insufficient precursor supply results in the catabolism of a large part of synthesized progesterone before its release from luteal cells and suggest the presence of a high affinity but low capacity 20 alpha-HSD in active corpora lutea.
Vivir en un mundo invertido: Entrevista a Eduardo Subirats (2016)

La obra del filosofo y profesor de la Universidad de Nueva York Eduardo Subirats esta signada por la pasion. Nada puede ser profundo sin pasion, y pasion acarrea sufrimiento.
Catching the Unique Rabbit: Why Pets Should Be Reclassified as Inimitable Property under the Law (2008)

This Note introduces a new approach for resolving the issue of inadequate compensation for pet loss by arguing for the adoption of a new classification of personal property called inimitable property. The new categorization takes into consideration the live, conscious, and unique qualities of pets that distinguish them from other sorts of inanimate property.
Recent applications of flow cytometry in aquatic microbial ecology (1993)

Microorganisms (unicellular algae, bacteria) constitute fundamental compartments of aquatic ecosystems because of their high concentrations and activities. The evaluation and understanding of their behavior and role raise different problems for which traditional methodologies are often inadequate, whether they refer to global or classical microscopic analyses. Flow cytometry (FCM) has been recently used to study microorganisms in aquatic environments. Although this technology is still applied on a limited scale in our field, a large number of works has been done showing that FCM seems to be a promising tool for aquatic microbial ecology. This paper summarizes, from the literature produced during the last decade and with original data obtained in our laboratory, the main questions related to the cell identification, the evaluation of cell viability, biomasses and productions and the measurements of bacterial and phytoplanktonic activities. The representatives of sampling and observation scales is also discussed within the framework of the FCM measurements.
International Trust Fund (2009)

The International Trust Fund for Demining and Mine Victims Assistance is an organization that raises donations for mine action in Southeastern Europe and administers the donations to areas in need. The goal of the organization is to “eliminate the effect of mine contamination ... by 2010.” In 2008, the ITF managed US$33,999,200 in donations from 31 organizations (such as nongovernmental organizations, civic organizations, philanthropies and private companies) and 13 donor countries. It was the largest amount of donations the ITF had received in any single year.
Research on Sag Online Monitoring System for Power Transmission Wire Based on Tilt Measurement (2013)

Sag online monitoring system for power transmission wire based on tilt angle measurement was proposed, the mathematical model of catenary for power wire was established. Sag calculation models of power wire in the situation without swinging and swinging were derived. By measuring the power wire axial angle and swing angle with dual-axis tilt sensor, the sag could be accurately calculated with the wire swinging. By testing the sag detection system, the result showed that the sag detection system could meet the engineering requirements of sag measurement.
SELECTIVE ATTENTION: THE EFFECTS OF COMBINING STIMULI WHICH CONTROL INCOMPATIBLE BEHAVIOR<sup>1</sup> (1969)

Four rhesus monkeys learned both a color and tilt discrimination. The stimuli were combined to produce incompatible behavior. The behavior controlled by one set of stimuli was reinforced until "errors" virtually disappeared. The stimuli were tested separately again. Sixteen replications of the entire procedure indicated that the stimuli producing "errors" were ignored.
Proteolytic activity of Clostridium difficile (1992)

Ten isolates of Clostridium difficile expressing different degrees of toxigenicity and virulence in an animal model were assayed for the production of proteolytic enzymes by various methods. All strains demonstrated some activity in one or more of the assay systems. There was no direct correlation between toxigenic status and enzyme production. However, those strains known to be highly virulent in a hamster model were the most proteolytic. The most commonly detected enzyme was cell associated, and its substrate specificity suggested it was a trypsin-like enzyme. Initial purification of the enzyme from strain VPI 10463 gave a 10% yield with a 14-fold increase in purity. Inhibition studies on this preparation indicated that the enzyme was a thiol protease. The enzyme has pH and temperature optima of 7.5 and 37 degrees C, respectively. These characteristics suggest that the enzyme is more related to clostripain, the thiol clostridio-peptidase of C. histolyticum, than to trypsin. Whilst the role of this enzyme remains unclear, it is possible that it may be a contributory factor in the virulence of the organism as described for other clostridial infections.
Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the .beta.-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium (1992)

In an effort to understand the catalytic mechanism of the tryptophan synthase beta-subunit from Salmonella typhimurium, possible functional active site residues have been identified (on the basis of the 3-D crystal structure of the bienzyme complex) and targeted for analysis utilizing site-directed mutagenesis. The chromophoric properties of the pyridoxal 5'-phosphate cofactor provide a particularly convenient and sensitive spectral probe to directly investigate changes in catalytic events which occur upon modification of the beta-subunit. Substitution of Asp for Glu 109 in the beta-subunit was found to alter both the catalytic activity and the substrate specificity of the beta-reaction. Steady-state kinetic data reveal that the beta-reaction catalyzed by the beta E109D alpha 2 beta 2 mutant enzyme complex is reduced 27-fold compared to the wild-type enzyme. Rapid-scanning stopped-flow (RSSF) UV-visible spectroscopy shows that the mutation does not seriously affect the pre-steady-state reaction of the beta E109D mutant with L-serine to form the alpha-aminoacrylate intermediate, E(A-A). Binding of the alpha-subunit specific ligand, alpha-glycerol phosphate (GP) to the alpha 2 beta 2 complex exerts the same allosteric effects on the beta-subunit as observed with the wild-type enzyme. However, the pre-steady-state spectral changes for the reaction of indole with E(A-A) show that the formation of the L-tryptophan quinonoid, E(Q3), is drastically altered. Discrimination against E(Q3) formation is also observed for the binding of L-tryptophan to the mutant alpha 2 beta 2 complex in the reverse reaction. In contrast, substitution of Asp for Glu 109 increases the apparent affinity of the beta E109D alpha-aminoacrylate complex for the indole analogue indoline and results in the increased rate of synthesis of the amino acid product dihydroiso-L-tryptophan. Thus, the mutation affects the covalent bond forming addition reactions and the nucleophile specificity of the beta-reaction catalyzed by the bienzyme complex.