gebhart/patrepeval huggingface dataset:
Afferent innervation influences HVA Ca2+ current expression in cultured neocortical neurones (1998)

Voltage-activated Ca2+ channels represent a major pathway of Ca2+ entry into neurones. The regulation of the expression of functional Ca2+ channels thus plays a central role in neuronal differentiation. To study the influence of afferent innervation on Ca2+ current expression, we compared HVA Ca2+ currents in two categories of cultured neocortical neurones that showed pronounced differences in synaptic innervation density. Neurones strongly innervated by a presynaptic explant had a two-fold greater HVA Ca2+ current density than neurones not innervated by explant fibres. Chronic blockade of synaptic activity did not affect HVA Ca2+ current density in innervated neurones. Our results thus suggest an activity-independent regulation of HVA Ca2+ current expression by afferent innervation.
248 (2014)

Park, Timothy1; Batchinsky, Andriy2; Baker, William3; Belenkiy, Slava4; Jordan, Bryan3; Dubick, Michael4; Salinas, Jose4; Cancio, Leopoldo4 Author Information
A 60-GHz Injection-Locked Frequency Divider Using Multi-Order LC Oscillator Topology for Wide Locking Range (2011)

A 60-GHz injection-locked frequency divider (ILFD) is presented. A multi-order LC oscillator topology is proposed to enhance the locking range of the divider. A design guideline is described based on a theoretical analysis of the locking range enhancement. A test chip is fabricated in 65nm CMOS. Measured locking range with 0dBm input power is 48.5-62.9GHz (25.9%), which is 63.6% wider compared to the previously reported ILFD. Power consumption excluding buffers and biasing circuits is 1.65mW from 1.2V supply. The core ILFD area is 0.0157mm2 even with an extra pair of inductors.
Infrared Radiation Detection with YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-d</sub> Microbridge (1991)

The photoresponse of YBa 2 Cu 3 O 7- d thin film with double bridges (DC-SQUID type) has been investigated under irradiation of weak laser light. The YBCO thin film of 200 nm thickness was prepared on a MgO(100) single-crystal substrate by an rf-magnetron sputtering method. It was processed to perform as a double microbridge (DC-SQUID type) patterned by ECR ion etching and then assembled as an YBCO thin-film sensor. The microbridge used here was 5 µm in width and 7.5 µm in length. The sensitivity of the sensor was determined by irradiating a modulated laser light (modulating frequency of 17 to 400 Hz, wavelength of 827 nm). The device showed both bolometric and nonbolometric behavior in the superconducting transition region. The maximum noise equivalent power (NEP) and responsivity was obtained at 76 K, and was 5×10 -9 W/Hz 1/2 and 19 V/W, respectively. The nonbolometric response was caused by vortex motion.
Four new Centipeds of the genus Cryptops (1939)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Partial Bitstream 2-D Core Relocation for Reconfigurable Architectures (2009)

Field programmable gate arrays (FPGAs) potentially offer enhanced reliability, recovery from failures through partial and dynamic reconfigurations, and eliminate the need for redundant hardware typically used in fault-tolerant systems. Our earlier work on scalable self-configurable architectures for reusable space systems (SCARS) describes a partial reconfiguration based self-healing architecture. The implementation of this architecture with the currently available industry tools has taught us a few valuable lessons. Generating the partially reconfigurable cores has acute restrictions that limit our ability to relocate the cores to other regions of the FPGA leading to poor area utilization. State of the art relocation approaches in the academia employ complex relocation management mechanisms which prohibit these solutions to operate at run time. In this paper, we propose a methodology for run-time 2-D core relocation to overcome the above issues. We show that our approach increases reconfiguration area utilization by 36% and reduces partial bitstream storage memory usage by 91% when compared to our base implementation. Conventional solutions restrict a given functionality to be partially reconfigured in a predetermined area. This technology enables the designer to move any core to anywhere on the FPGA fabric providing more resource availability when recovering from failure.
ChemInform Abstract: Synthesis and Antimicrobial Properties of Substituted β‐Aminoxypropionyl Penicillins and Cephalosporins. (1989)

Abstract The oximes (I) are coupled with ethyl acrylate (II), yielding the β‐(methylene)aminoxypropionic acid esters (III) which are hydrolyzed to give the corresponding acids (IV).
A criteria-based approach to grasp synthesis (2003)

This study introduces a criteria-based methodology for grasp synthesis. The method allows the use of multiple performance criteria both at the finger and the hand levels, which are used to generate a preliminary grasp and an optimum grasp, respectively. The approach offers reduced complexity by decomposing grasp synthesis into manageable phases. A case study using a physical hand demonstrates the effectiveness of the method.
Prevalence and genotypes of Giardia duodenalis in dairy and beef cattle in farms around Charlottetown, Prince Edward Island, Canada. (2011)

Prevalence of Giardia duodenalis in dairy and beef cattle on farms around Charlottetown, Prince Edward Island (Canada) was determined by analyzing feces using direct immunofluorescence antibody microscopy. Genotypes were determined by 16S-rRNA sequencing. Fecal samples (n = 892) were collected from adult cattle in dairy tie-stall, dairy free-stall, and beef herds (10 herds each), and from calves (n = 183) from 11 dairy farms. Prevalence rates were 38% and 51% in cows and calves, respectively. Giardia duodenalis was present in all dairy herds, in 9/10 beef herds and in calves from 10/11 herds examined. Prevalence rates were 40% and 41% for cows in tie- and free-stall herds, respectively, and 27% for beef cows. Zoonotic Assemblage A was found in 12.2% of calves concomitantly infected with Assemblage E. All successfully sequenced samples (114/128) from cows corresponded to Assemblage E. Giardia duodenalis is highly prevalent in cattle herds in Prince Edward Island and Assemblage A in calves is a potential public health concern.
Characterization of paternity relationships in the mole rat <i>Spalax ehrenbergi</i> by microsatellite genotyping (2011)

Abstract Spalax ehrenbergi is a species complex of blind subterranean rodents distributed along the east Mediterranean region. We studied genetic relationships within and between S. ehrenbergi sib families using microsatellite genotyping. The upper‐bound level of multiple‐paternity rate in litters was estimated using a simulation model of breeding process. Our results show that the upper bound of multiple paternity in the studied population of S. ehrenbergi is <30% ( P value 2.9%), with no detected cases of multiple paternity. Our analytical model was specifically designed for a situation in which the sibling identities are known but genetic data about their parents is unavailable. The genetic similarities between groups of individuals were also tested, and it was found that the distance between breeding nests is a factor influencing the genetic similarity between litters found in the nests.
On the comparability of medical image measurements in cancer clinical trials (2012)

Biomarkers detectable by imaging methods are increasingly used as surrogate endpoints to establish the severity of a disease to evaluate the efficacy of a treatment method or chemotherapy drug in cancer clinical trials. In therapeutic cancer clinical trials, the tumors are measured from medical images such as CT or MR at a baseline time point and the treatment response assessment is followed-up on a frequent basis at subsequent time intervals. In this paper, we will try to evaluate to which degree the measurements from medical images are comparable for clinical trials by specifying sources of uncertainties of image measurements in order to support both clinical trial investigators by giving them confidence in their interpretation of the measurements results and implementers to follow the best-practice guidelines to be taken into consideration to minimize sources of such variability.
Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment (2012)

The synthesis of a novel functional biomaterial for wound healing treatment was carried out by adopting a free-radical grafting procedure in aqueous media. With this aim, ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing an ascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalent insertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, while an antibacterial assay demonstrated the activity of the synthesized conjugate against Staphylococcus aureus and Escherichia coli, microorganisms that commonly infect wounds. A catechin blended conjugate was also tested in order to evaluate the ability to influence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatment encouraging the healing process.
Cognition to design energetically efficient and impairment aware virtual topologies for optical networks (2012)

“Greening the Internet” is an important research topic in the last years. The Internet capacity and energy consumption have increased, and the utilization of design and operation techniques to reduce this consumption are a must. In this paper, we present a multiobjective genetic algorithm to design virtual topologies for reconfigurable wavelength-routed optical networks with the aim of reducing both the energy consumption and the network congestion while ensuring that the lightpaths of the virtual topologies fulfill quality of transmission requirements. Moreover, we also present another version of that method enhanced with cognitive techniques, and we show, by means of simulation, the performance advantages brought when introducing these cognitive techniques.
G030014 Effect of Stress Ratio on Giga-Cycle Fatigue Properties of Ti-6A1-4V ELI Alloy (2012)

The effect of stress ratio on giga-cycle fatigue properties was investigated for two heats of 900 MPa-class Ti-6Al-4V ELI alloy. Fatigue tests were carried out using ultrasonic fatigue testing at 20 kHz and conventional fatigue testing at 120 Hz. These fatigue tests were conducted under stress ratios of R = -1, 0 and 0.3 and under the condition fixing the maximum stress at the yield stress. As the result, internal fracture occurred in both heats above R = 0, and in that case, frequency effects were negligible. In these tests, no specimen failed at over 10^9 cycles, which meant that the Ti-6Al-4V ELI alloy probably revealed fatigue limits in a giga-cycle region in spite of occurrence of internal fracture. The fracture sites of the internal fracture revealed no inclusion but a cluster of several facets. The fatigue limits determined at 10^<10> cycles were below a modified Goodman line under R=0 and 0 3. The above frequency effects and giga-cycle fatigue properties of Ti-6Al-4V ELI alloy were coincident with those of conventional Ti-6Al-4V alloy obtained by previous experiment.
State space modeling of non-causal impulse responses (1982)

In this short paper we present a state-variable model for a non-causal impulse response (IR). The IR is split into causal and anti-causal parts. The anti-causal part is then converted into an equivalent causal state-variable model. The order of the complete system is 2n, where n is the order of the original causal portion of the two-sided IR. Because n can be kept quite low (e.g., 2 or 3) the overall order for our complete system is also quite low. Simulations, as well as analysis, demonstrate that our state-variable model is equivalent to the original two-sided convolutional system model.
Tailoring Nd3+ emission spectrum by a neodymium-doped tellurite all-solid photonic bandgap fiber (2018)

A tellurite all-solid photonic bandgap fiber (ASPBF) whose cladding consists of 60 high-index rods arranged periodically around a central core was successfully fabricated. The diameter of high-index rod was about 5.0 μm and the distance between the center of two adjacent high-index rods was approximately 8.0 μm. The high-index rod was made of the TeO<sub>2</sub>-Li<sub>2</sub>O-WO<sub>3</sub>-MoO<sub>3</sub>-Nb<sub>2</sub>O<sub>5</sub> (TLWMN) glass, the cladding was made of the TeO<sub>2</sub>-ZnO-Na<sub>2</sub>O-La<sub>2</sub>O<sub>3</sub> (TZNL) glass as the background glass material and the central core was made of TZNL glass doped with 0.5 wt% of Nd<sub>2</sub>O<sub>3</sub>. A supercontinuum light from 0.6 to 2.4 μm was coupled into the core of fiber which is 2.2 cm long to measure its transmission spectrum. High transmission bands were obtained in the vicinity of 0.75 and 1.3 μm but the transmission was suppressed in the wavelength range from 1.0 to 1.06 μm. When a titanium∶Sapphire laser source at 0.75 μm was used, the emission spectrum was obtained with two peaks at 1.06 and 1.33 μm which are attributed to the <sup>4</sup>F<sub>3/2</sub>→<sup>4</sup>I<sub>11/2</sub> and <sup>4</sup>F<sub>3/2</sub>→<sup>4</sup>I<sub>13/2</sub> transitions of Nd<sup>3+</sup> ion, respectively. The intensities of those emission peaks were compared with those obtained from a bulk glass having the same doping concentration of Nd<sup>3+</sup>. The results showed that by using tellurite ASPBF, the intensity of the 1.06-μm emission was suppressed by one-twelfth but the intensity of the 1.33-μm emission was maintained. This feature is very advantageous to filter out the 1.06-μm emission of Nd<sup>3+</sup> ion in order to realize practical amplifier devices at 1.3 μm.
Genotoxicity of acrylamide in vitro: Acrylamide is not metabolically activated in standard in vitro systems (2010)

The recent finding that acrylamide (AA), a genotoxic rodent carcinogen, is formed during the frying or baking of a variety of foods raises human health concerns. AA is known to be metabolized by cytochrome P450 2E1 (CYP2E1) to glycidamide (GA), which is responsible for AA's in vivo genotoxicity and probable carcinogenicity. In in-vitro mammalian cell tests, however, AA genotoxicity is not enhanced by rat liver S9 or a human liver microsomal fraction. In an attempt to demonstrate the in vitro expression of AA genotoxicity, we employed Salmonella strains and human cell lines that overexpress human CYP2E1. In the umu test, however, AA was not genotoxic in the CYP2E1-expressing Salmonella strain or its parental strain. Moreover, a transgenic human lymphoblastoid cell line overexpressing CYP2E1 (h2E1v2) and its parental cell line (AHH-1) both showed equally weak cytotoxic and genotoxic responses to high (>1 mM) AA concentrations. The DNA adduct N7-GA-Gua, which is detected in liver following AA treatment in vivo, was not substantially formed in the in vitro system. These results indicate that AA was not metabolically activated to GA in vitro. Thus, AA is not relevantly genotoxic in vitro, although its in vivo genotoxicity was clearly demonstrated.
Brief communication: Evidence of <i>Bartonella quintana</i> infections in skeletons of a historical mass grave in Kassel, Germany (2011)

In 2008, a mass grave was found on the grounds of the University of Kassel, Germany. Historians hypothesized that the individuals died in a typhoid fever epidemic in winter 1813/14. To test this hypothesis, the bones were investigated on the presence of specific DNA of pathogens linked to the historical diagnosis oftyphoid fever. It was possible to prove the specific DNA of Bartonella quintana in three individuals, suggesting that their cause of death is linked to an epidemic background.
Normed ring of a locally compact abelian group (1943)

1. Let G be a locally compact (not necessarily separable) abelian group, and let L2(G) be the generalized Hilbert space of all complex-
Vibrational symmetry breaking of supported nanospheres (2012)

Coherent particle vibrations of gold nanospheres on a solid surface are detected by optical spectroscopy and time-resolved x-ray scattering. A new dominant mode arises, which is described by the monopolar mode symmetry forbidden of free spheres. Molecular dynamics studies of single-crystalline and polycrystalline particles confirm the assignment of these modes.
Image restoration based on estimation of fractal structure (2002)

In this paper, image restoration under unknown degradation process (hard to make a mathematical model of the degradation process) will be treated, and a novel approach adopting fractal coding is proposed. The method begins, as a pre-processing, with the construction of a table of range-domain correspondences on a degraded image using known pairs of an original image and its degraded image. In the restoration phase, the fractal structure of an unknown image is, first, estimated from an input image by using the table, and next, a restored image is generated by the decoding process. The fractal decoding procedure is evolved by the concept of the fuzzy vector quantization to diminish the distortion of a decoded image. Features and effectiveness are examined through some simulations.
A Further Separation and Some Properties of β-Lactamase I (1980)

Journal Article A Further Separation and Some Properties of β-Lactamase I Get access Teruhiko Akiba, Teruhiko Akiba The Institute of Physical and Chemical Research, Wako, Saitama 351, Japan Search for other works by this author on: Oxford Academic Google Scholar Koki Horikoshi Koki Horikoshi The Institute of Physical and Chemical Research, Wako, Saitama 351, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 44, Issue 11, 1 November 1980, Pages 2741–2742, https://doi.org/10.1080/00021369.1980.10864399 Published: 01 November 1980 Article history Received: 13 May 1980 Published: 01 November 1980
Syndiospecific Polymerization of Propene with [<i>t</i>-BuNSiMe<sub>2</sub>Flu]TiMe<sub>2</sub>-Based Catalysts by Chain-End Controlled Mechanism (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSyndiospecific Polymerization of Propene with [t-BuNSiMe2Flu]TiMe2-Based Catalysts by Chain-End Controlled MechanismHideaki Hagihara, Takeshi Shiono, and Tomiki IkedaView Author Information Research Laboratory of Resources Utilization, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku Yokohama 226, Japan Cite this: Macromolecules 1997, 30, 16, 4783–4785Publication Date (Web):August 11, 1997Publication History Received14 March 1997Revised17 June 1997Published online11 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ma970352zhttps://doi.org/10.1021/ma970352zrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views424Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Aromatic compounds,Catalysts,Hydrocarbons,Polymerization Get e-Alerts
Beating Cardiomyocytes against Oxidative Damage (1991)

The protective effect of stable nitroxide radicals against oxidative damage was studied using cardiomyocyte cultures obtained from newborn rats. Monolayered cardiomyocytes were exposed to H202 and the effect on spontaneous beating and leakage of LDH was determined. Hydrogen peroxide irreversibly blocked rhythmic beating and resulted in a significant membrane injury as shown by release ofLDH. The injury was prevented by catalase which removes H202 and by cell-permeable, metal-chelating agents such as desferrioxamine or bipyridine. In contrast, reagents which are excluded from the cell such as superoxide dismutase or DTPA did not protect the cells against H202. Five- and six-membered ring, stable nitroxide radicals which have previously been shown to chemically act as low-molecular weight, membrane-permeable, SOD-mimetic compounds provided full protection. The nitroxides prevented leakage ofLDH and preserved normal cardiomyocyte contractility, presumably by intercepting intracellularO radicals. Alternatively, protectionmay result through nitroxides reacting with reduced transition metal ions or by detoxifying secondary organic radicals. (J.
CaCu<sub>3</sub>Ti<sub>4</sub>O<sub>12</sub>-type Colossal Dielectric Relaxation in Complex Perovskite (Ba<sub>1 −<i>x</i></sub>La<sub><i>x</i></sub>)(Ti<sub>1 −<i>x</i></sub>Cr<sub><i>x</i></sub>)O<sub>3</sub> (2007)

Dielectric constants of complex perovskite oxide (Ba 1 − x La x ) (Ti 1 − x Cr x ) O 3 (BLTC) ceramics with 0.4 ≤ x ≤ 0.7 are measured, and a remarkable colossal dielectric relaxation which is quite similar to that of CaCu 3 Ti 4 O 12 (CCTO) is found in higher temperature region above the ferroelectric phase transition. This kind of dielectric relaxation is successfully explained by an equivalent circuit model of a series of two R−C parallel circuits with temperature-dependent electrical conductivity and temperature-independent intrinsic dielectric constant. It is also found that the dc bias effect on the sample can distinguish this hetero-structure model and the proper Debye relaxation model of a homogeneous phase.
Evidence for Two Subgroups of CD4−CD8− NKT Cells with Distinct TCRαβ Repertoires and Differential Distribution in Lymphoid Tissues (2000)

NKT cells are a subset of T lymphocytes that is mainly restricted by the nonclassical MHC class I molecule, CD1d, and that includes several subpopulations, in particular CD4+ and CD4-CD8- (DN) cells. In the mouse, differential distribution of these subpopulations as well as heterogeneity in the expression of various markers as a function of tissue localization have been reported. We have thus undertaken a detailed study of the DN NKT cell subpopulation. With a highly sensitive semiquantitative RT-PCR technique, its TCR repertoire was characterized in various tissues. We found that mouse DN NKT cells are a variable mixture of two subgroups, one bearing the invariant Valpha14 chain paired to rearranged Vbeta2, Vbeta7, Vbeta8.1, Vbeta8.2, or Vbeta8.3 beta-chains and the other exhibiting unskewed alpha- and beta-chains. The proportion of these subgroups varies from about 100:0 in thymus, 80:20 in liver, and 50:50 in spleen to 20:80% in bone marrow, respectively. Finally, further heterogeneity in the tissue-derived DN NKT cells was discovered by sequencing extensively Vbeta8.2-Jbeta2.5 rearrangements in individual mice. Despite a few recurrences in TCR sequences, we found that each population exhibits its own and broad TCRbeta diversity.