gebhart/patrepeval huggingface dataset:
Regulation of procollagen synthesis and processing during ascorbate-induced extracellular matrix accumulation <i>in vitro</i> (1990)

Procollagen biosynthesis and matrix deposition were studied in long-term human skin fibroblast cultures exposed to ascorbic acid. Ascorbic acid specifically stimulated types I and III collagen synthesis, reaching a maximum at day 2 and maintaining a specific high rate of production until day 10 of ascorbate exposure, after which collagen production declined. The increased level of collagen synthesis after different exposure times could also be achieved by only brief treatment (10 h) of parallel scorbutic (ascorbic-acid-deficient) cultures with ascorbic acid. This brief exposure did not result in increased collagen mRNA, thus demonstrating that the ascorbate-induced increase in collagen synthesis at all stages of ascorbic acid exposure was due to post-transcriptional mechanisms, most likely a rapid increase in type 1 collagen mRNA translational efficiency. This mechanism, rather than the transcriptional activation, was the primary response and is adequate to explain the ascorbate-induced increase in collagen synthesis. These data also demonstrate that the presence of a collagenous extracellular matrix was not involved in this collagen biosynthetic regulation. During long-term exposure (18 days) to ascorbic acid, a substantial cross-linked collagenous matrix formed, following an approximately sigmoidal time course. The most rapid matrix deposition occurred during the later days of exposure when the rate of collagen synthesis was decreasing, suggesting that the presence of a pre-existing matrix is important for further collagen accumulation. Procollagen was also efficiently processed to collagen during this phase, demonstrating that efficient procollagen processing is an important regulatory event in collagen matrix deposition.
Managing signal integrity [PCB design] (1994)

As system clock rates race to 100 MHz and beyond, designers of printed-circuit boards and multichip modules must watch out for such high-speed effects as ground bounce, ringing, reflections, and crosstalk. The author describes how today's high-speed printed-circuit boards and multichip modules require integrated design systems that include signal integrity analysis tools.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Alaska's Vanishing Arctic Cuisine (2002)

Research Article| February 01 2002 Alaska's Vanishing Arctic Cuisine Zona Spray Zona Spray Search for other works by this author on: This Site PubMed Google Scholar Gastronomica (2002) 2 (1): 30–40. https://doi.org/10.1525/gfc.2002.2.1.30 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Zona Spray; Alaska's Vanishing Arctic Cuisine. Gastronomica 1 February 2002; 2 (1): 30–40. doi: https://doi.org/10.1525/gfc.2002.2.1.30 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentGastronomica Search This content is only available via PDF. Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine (2017)

Whereas the physiologic wound healing (WH) successfully proceeds through the clearly defined sequence of the individual phases of wound healing, chronic non-healing wounds/ulcers fail to complete the individual stages and the entire healing process. There are many risk factors both modifiable (such as stress, smoking, inappropriate alcohol consumption, malnutrition, obesity, diabetes, cardio-vascular disease, etc.) and non-modifiable (such as genetic diseases and ageing) strongly contributing to the impaired WH. Current statistics demonstrate that both categories are increasingly presented in the populations, which causes dramatic socio-economic burden to the healthcare sector and society at large. Consequently, innovative concepts by predictive, preventive and personalised medicine are crucial to be implemented in the area. Individual risk factors, causality, functional interrelationships, molecular signature, predictive diagnosis, and primary and secondary prevention are thoroughly analysed followed by the expert recommendations in this paper.
Reduced volume PCR amplification reactions using the AmpFlSTR Profiler Plus kit. (2002)

The forensic community continues to seek improvements in DNA typing methods on aspects such as sensitivity and efficacy. Reducing the volume of the AmpFlSTR Profiler Plus reagents offered greater sensitivity and improved the chance of obtaining useful results for samples with very low quantities of DNA and multiple source samples. On the downside, amplifications initiated with less than 0.4 ng of DNA exhibited a twofold increase in the standard deviation of peak ratios. This research suggested a twofold approach to analyzing samples. For samples with greater than 0.25 ng of DNA, a 25 microL reaction is appropriate. Samples that did not demonstrate quantifiable results, or that have less than 0.25 ng, can be amplified by drying the sample directly in the PCR tube and amplifying in a 5 microL reaction. The analyst can expect at least limited results with as little as 0.03 ng of DNA in the 5 microL reaction.
A 5.2-GHz LNA in 0.35-μm CMOS utilizing inter-stage series resonance and optimizing the substrate resistance (2003)

A current-reused two-stage low-noise amplifier (LNA) topology is proposed, which adopts a series inter-stage resonance and optimized substrate resistance of individual transistors. The characteristics of the series inter-stage resonance in gain enhancement are analyzed and compared with other alternatives. The contradicting effects of substrate resistance on common-source and common-gate amplifiers are analyzed and proposed guidelines for high-gain operation. The LNA is implemented based on a 0.35-μm CMOS technology for 5.2-GHz wireless LAN applications. Measurements show 19.3dB of power gain, 2.45 dB of noise figure, and 13.2 dBm of output IP3, respectively, for the dc power supply of 8 mA and 3.3 V.
Induction of skin carcinogenicity by alcohol and ultraviolet light (2009)

In western societies, casual consumption of alcohol during such outdoor activities as barbecuing and sunbathing is common. The current literature shows that alcohol drinkers have increased episodes of sunburn and a higher prevalence of skin cancer. Moreover, recent evidence suggests that the combination of subcarcinogenic (minimal) ultraviolet (UV) exposure with other behavioural, environmental and xenobiotic factors has resulted in increased incidents of skin-related health problems that also result in skin-cancer formation. We hypothesize that the combination of alcohol consumption with UV radiation can potentiate the skin carcinogenic effects through the intermediate biproducts or metabolites of alcohol, which serve as the photosensitizers, consequently enhancing the cellular damage. We have proposed a mechanism that explains the combined alcohol-UV radiation carcinogenicity and its potential involvement in enhancing skin damage in the multistep skin carcinogenesis process. Previous literature has explored this mutual effect but no studies have definitively ascribed the reasons for increased skin cancer prevalence among alcohol drinkers. Nevertheless, the preceding epidemiological data and clinical studies recognize this matter, making the further testing of this hypothesis necessary.
Radiation from a cylindrical source of finite length (1953)

Abstract This paper presents the results of a theoretical study of radiation from a cylindrical source of finite length, the walls of which are subjected to symmetric lateral and tangential stresses. Three divergent wave systems are generated, P, SV, and SH, and their amplitudes are calculated in terms of the stresses operative on the walls of the "equivalent cavity". The zonal distribution of amplitude in the three wave systems is calculated, and the total amount of energy in each is estimated. It is shown that under the action of a lateral pressure only, an SV wave of amplitude 1.6 times the maximum amplitude of the associated P-wave is beamed from the source in directions making angles of 45 degrees with the axis of the source.
Post-antibiotic effect of isepamicin compared to that of other aminoglycosides. (1990)

Isepamicin is a new aminoglycoside drug derived from gentamicin, which is more stable than other aminoglycosides to inactivating enzymes and experimentally is less nephrotoxic than gentamicin or amikacin. In this work a comparative study was carried out on the antibacterial activity (MIC and lethality curves) and the post-antibiotic effect (PAE) of different concentrations of isepamicin, netilmicin and gentamicin on pure cultures of S. aureus and E. coli. The MIC and curves of lethality were determined by conventional methods. The PAE was determined after exposure of the bacterial culture to the antimicrobial one for 1 h at 37 degrees C in a bath with stirring. Elimination of the drug was made by the dilution method. Isepamicin was found to have a MIC four times greater than netilmicin and gentamicin. Its activity over time was similar to that exhibited by other aminoglycosides. At concentrations higher than the MIC, a bactericidal effect was found with the three antibiotics, although isepamicin produced it at lower concentrations. The post-antibiotic effect induced by isepamicin, the same as that of netilmicin and gentamicin, was extensive and depended on the concentration and the strain used. Isepamicin shows antibiotic activity over time and a PAE similar to the other aminoglycosides tested but, unlike them, it has a faster activity, less toxicity and better resistance to inactivating enzymes. For this reason it makes a considerable contribution to antibacterial therapies in severe conditions, including immunodepressed patients who require long-term treatment.
Molecular Physiology of Water Balance (2015)

In this article, the authors review the classic, integrative principles of water balance. They use this model to discuss the role of underlying genes and gene products (proteins) in water balance and to provide a mechanistic basis for decisions about related disorders.
Microsoft Outlook programming : jumpstart for administrators, power users, and developers (2003)

What You Can Do with Outlook Part I: Outlook VBA Design The VBA Design Environment A VBA Birthday/Anniversary Reminder Form PART II: Adding VBA Code Code Basics Code Grammar 101 Working with Expressions and Functions Controlling Program Flow Handling Errors and Debugging VBA Applications Handling User Input and Feedback PART III: Special Outlook Techniques Working with the Object Models Responding to Outlook Events in VBA Working with Stores and Folders Understanding Outlook Security Working with Items and Recipients Part IV: Outlook Form Design Outlook's Six Basic Forms Creating Your First Custom Contact Form Extending Form Design with Fields and Controls Writing Code to Respond to Outlook Form Events More Controls for Outlook Forms Common Outlook Form and Item Techniques Part V: Finishing Touches Menus, Toolbars, and the Outlook Bar Designing Outlook Reports Exchange Server, Databases, and XML Web Services Deploying Forms and Applications Appendices: Resources for Outlook Programming Files Blocked by Outlook Security Key Procedures You Can Reuse
Sudden fetal death in women with well-controlled, intensively monitored gestational diabetes. (1992)

An intensive antepartum monitoring system for women with gestational diabetes mellitus was evaluated over a 5-year period. Early diagnosis and liberal treatment with insulin was concomitantly followed with non-stress testing: weekly from 28 to 34 weeks' gestation and semi-weekly thereafter. Despite maternal euglycemia and satisfactory antepartum assessment, three fetal deaths occurred within 72 hours of reassuring fetal monitoring. Additionally, 24 (7%) fetuses were delivered on the basis of a low biophysical profile score (less than 6) at term. The stillbirth rate for women with gestational diabetes was 7.7/1000, whereas the stillbirth rate for nondiabetic low-risk patients was 4.8/1000. Women with gestational diabetes continue to be in a high-risk category for antepartum fetal death, requiring intensive monitoring with consideration for timely delivery.
The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance (2020)

While forming a minor population in the blood and lymphoid compartments, T cells are significantly enriched within barrier tissues. In addition to providing protection against infection, these tissue-resident T cells play critical roles in tissue homeostasis and repair. T cells in the epidermis and intestinal epithelium produce growth factors and cytokines that are important for the normal turnover and maintenance of surrounding epithelial cells and are additionally required for the efficient recognition of, and response to, tissue damage. A role for tissue-resident T cells is emerging outside of the traditional barrier tissues as well, with recent research indicating that adipose tissue-resident T cells are required for the normal maintenance and function of the adipose tissue compartment. Here we review the functions of tissue-resident T cells in the epidermis, intestinal epithelium, and adipose tissue, and compare the mechanisms of their activation between these sites.
The Network Structure of Exploration and Exploitation (2007)

Whether as team members brainstorming or cultures experimenting with new technologies, problem solvers communicate and share ideas. This paper examines how the structure of communication networks among actors can affect system-level performance. We present an agent-based computer simulation model of information sharing in which the less successful emulate the more successful. Results suggest that when agents are dealing with a complex problem, the more efficient the network at disseminating information, the better the short-run but the lower the long-run performance of the system. The dynamic underlying this result is that an inefficient network maintains diversity in the system and is thus better for exploration than an efficient network, supporting a more thorough search for solutions in the long run. For intermediate time frames, there is an inverted-U relationship between connectedness and performance, in which both poorly and well-connected systems perform badly, and moderately connected systems perform best. This curvilinear relationship between connectivity and group performance can be seen in several diverse instances of organizational and social behavior.
Accuracy of the One Touch II whole blood glucose analyzer when used by analysts with diverse technical backgrounds. (1993)

Our data suggest that the One Touch II glucose analyzer is a reliable system, and that its function is not dependent on the technical skills of the operator.
Improving bits allocation and quantization level control for MPEG2 encoders (2002)

In this paper two techniques have been proposed for improving coding performance of MPEG2 Simulation Test Model 5 (STM5) bit rate control scheme for constant bit rate (CBR) transmission applications. The first technique is to modify the quantization level produced by the STMS rate control scheme in such a way that the statistics of the quantization level applied to macro blocks (MBs) can be changed as desired. By adjusting control parameters, a range of variable bit rate (VBR) bit streams can be produced. The second technique uses a sliding window instead of a fixed length of group of pictures (GOP) in bit budget allocations, which leads to a more reasonable and fair bit allocation scheme. Combination of the two techniques has brought in average gains in peak signal to noise ratio (PSNR) from about 0.5 dB to about 1 dB. The techniques are simple yet effective and are therefore suitable for improving MPEG2 bit rate control performance.
Spline wavelets in numerical resolution of partial differential equations (2002)

We give a review of applications of spline wavelets in the resolution of partial differential equations. Two typical methods for numerical solutions of partial differential equations are Galerkin method and collocation method. Corresponding to these two methods, we present the constructions of semi-orthogonal spline wavelets and semiinterpolation spline wavelets respectively. We also show how to use them in the numerical resolution of various partial differential equations.
Handbook of assessment and treatment planning for psychological disorders. (2002)

Part I: Principles and Practice of Evidence-based Assessment. Hunsley, Mash, The Role of Assessment in Evidence-based Practice. Ayearst, Bagby, Evaluating the Psychometric Properties of Psychological Measures. Bufka, Camp, Brief Measures for Screening and Measuring Mental Health Outcomes. Summerfeldt, Kloosterman, Antony, Structured and Semistructured Diagnostic Interviews. Part II: Approaches for Specific Psychological Problems. Morissette, Bitran, Barlow, Panic Disorder and Agoraphobia. McCabe, Ashbaugh, Antony, Specific and Social Phobia. Campbell-Sills, Brown, Generalized Anxiety Disorder. Taylow, Abramowitz, McKay, Obsessive-Compulsive Disorder. Steenkamp, McLean, Arditte, Litz, Exposure to Trauma in Adults. Dozois, Dobson, Depression. Craighead, Smith, Obesity and Eating Disorders. Abbott, Snyder, Couple Distress. Pratt, Mueser, Schizophrenia. Tucker, Murphy, Kertesz, Substance Use Disorders. Widiger, Lowe, Personality Disorders. Tolin, Morrison, Impulse Control Disorders. Josee, Savard, Morin, Insomnia.
Purification and Initial Kinetic Characterization of Different Forms of O-Acetylserine Sulfhydrylase from Seedlings of Two Species of <i>Phaseolus</i> (1977)

Purification of O-acetylserine sulfhydrylase (OASS) from seedlings of two species of Phaseolus reveals the presence in both species of two forms of this enzyme. The isolation and purification procedure gives purification of 7- to 160-fold for individual isoenzymes with specific activities ranging from 33 IU mg(-1) to 775 IU mg(-1) protein.Detailed study of the basic kinetic parameters of the OASS isoenzymes indicates that both forms from Phaseolus vulgaris (which are of about equal specific activity) display substrate inhibition by S(2-) above 1 mm and positive cooperativity at lower concentrations of S(2-). With respect to O-acetylserine (OAS), the second substrate of the reaction, one P. vulgaris isoenzyme shows substrate inhibition by OAS concentrations above 10 mm, while the second is unaffected by OAS concentrations up to 50 mm. The isoenzymes from Phaseolus polyanthus (one of which has a specific activity 24 times higher than the other) are slightly and approximately equally inhibited by both S(2-) and OAS.
The generation, propagation, and detection of Lamb waves in plates using air-coupled ultrasonic transducers (1996)

Air-coupled nondestructive testing has become feasible following recent improvements in air-coupled transducer design. However, the large acoustic impedance mismatch between air and solid materials does not allow normal incidence pulse-echo inspection. Nevertheless, air-coupled transducers can be used for the generation and detection of Lamb waves, the receiver being outside the field of the specular reflection. A finite element study of the generation of Lamb waves in plates from a finite air-coupled transducer, the interaction of these waves with defects, and their detection using an air-coupled receiver is described. These predictions are compared with experimental results obtained on a variety of specimens using a pair of 1-3 composite, air-coupled transducers. The use of an ideal collimated beam in the model, instead of using the real pressure field generated by the transducers, is demonstrated to have a negligible effect on the predicted Lamb waves. It is shown both theoretically and experimentally that the measured amplitude of the Lamb waves is very sensitive to the alignment of the transducers with respect to the test structure, misalignment of 0.6° reducing the amplitude by around 50%. The detection of notches of various depths in steel plates is investigated, and the sensitivity of the technique with different choices of incident mode and different positions of the receiver with respect to the defect is discussed. It is shown that in metal structures it is most satisfactory to use the a0 mode since it has a large out-of-plane surface displacement and so is easy to excite.
X-ray imaging technology in medical applications (2007)

An introduction to 2D X-ray radiography and 3D computed tomography (CT) which are used inclinics and hospitals worldwide is given. The development, principles and primary applications of modern medicalimage equipment such as digital subtraction angiography, computed radiography, digital radiography, spiral CT,positron emission tomography/CT, and phase-contrast imaging are also described. Image post-processing is a veryimportant part of modern medical imaging equipment. Combined with medical a priori knowledge, modern CTscanners have even more powerful capabilities in computer-aided diagnosis.
Solid state physics simulations (1996)

Phonon Dispersion Curves and the Density of States. Lattice Specific Heat of Solids. Electron States in a One-Dimensional Lattice. Energy Bands, Gaps, and Eigenfunctions in an Infinite Lattice. Forced Motion of a Wave Packet in a 1-D Lattice. Inhomogeneous Semiconductor Laboratory. LCAO Workbench. Appendices.
A new genus and species of cave cockroach (Blaberidae: Oxyhaloinae) from Guinea, West Africa (2004)

A new genus and species of ovoviviparous blaberid cockroach, Simandoa conserfariam is described that lives in bat guano in a cave in Guinea, West Africa. The male's subgenital plate, styles, and genitalia clearly place it in the Blaberidae: Oxyhaloinae: Nauphoetini. It is close to Henschoutedenia and Nauphoeta, but lacks stridulating structures on the pronotum and tegmina which are present in some species of the other 2 genera. The taxon belongs in the “Guanobies” group of cockroaches and lives in bat guano that accumulates not far from the entrance of the cave where light is present: Simandoa shows none of the characteristics of a troglobite (obligate cave-dweller) which, compared to surface dwellers, has reduced eyes and wings.
Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease (1991)

<h3>Objective.</h3> —Oxidative phosphorylation (OXPHOS) deficiency due to hypoxemia or other causes was hypothesized to increase oxygen radical generation, damage mitochondrial DNA (mtDNA), and reduce adenosine triphosphate synthesis, resulting in compensatory OXPHOS gene induction. Therefore, we investigated the levels of mtDNA damage and OXPHOS transcripts in normal and ischemic hearts, and then in other forms of heart disease. <h3>Design.</h3> —DNA was extracted from the heart and the levels of the common 4977 base pair mtDNA deletion were quantitated as an index for mtDNA damage. Total RNA was extracted from hearts and analyzed for OXPHOS transcript levels. <h3>Results.</h3> —In control hearts, the 4977 base pair mtDNA deletion appeared at age 40 years and reached a maximum deletion of 0.0035%. Much higher levels were found in ischemic hearts (0.02% to 0.85%), as well as in three of 10 cases with other types of heart disease (0.017% to 0.16%). The OXPHOS transcripts were increased in all diseased hearts. <h3>Conclusion.</h3> —Ischemic hearts have increased mtDNA damage and OXPHOS gene expression, suggesting that mtDNA damage is associated with OXPHOS deficiency. Oxidative phosphorylation defects may also play a role in some other forms of cardiac disease. (<i>JAMA</i>. 1991;266:1812-1816)