gebhart/patrepeval huggingface dataset:
The Response to Catechol Amine Infusion During Salicylate-Induced Hypermetabolism in Man (1958)

The increase in oxygen consumption produced in man by salieylate administration is not associated with a rise in pulse rate or an increase in responsiveness to infusions of epinephrine or norepinephrine. It is suggested that the effects of thyroid hormone on the cardiovascular system are more dependent on the concentration of circulating thyroid hormone per se than on the concomitant increase in tissue oxygen consumption.
Human Parvovirus (HPV/B19) Infection with Purpura (1989)

A 33-year-old man complained of purpura (petechial hemorrhage) in chelidons, poples, axillae, and bilateral chest in addition to other symptoms such as lumbago, arthralgia, muscular pain, and fever. On the next day of the onset, human parvovirus (HPV/B19) antigen and HPV/B19 DNA were detected in his serum, and twelve days later IgM antibody to HPV/B19 became detectable. This case supports the relationship between purpura and HPV/B19 infection.
Multiagent modeling and simulation in human-robot mission operations work system design (2003)

This paper describes a collaborative multiagent modeling and simulation approach for designing work systems. The Brahms environment is used to model mission operations for a semi-autonomous robot mission to the Moon at the work practice level. It shows the impact of human-decision making on the activities and energy consumption of a robot. A collaborative work systems design methodology is described that allows informal models, created with users and stakeholders, to be used as input to the development of formal computational models.
snRNAs are reduced in the syncytiotrophoblast: a possible mechanism for regulation of human placental protein production (2013)

The multinucleate syncytiotrophoblast of the human placenta is formed by fusion of the underlying cytotrophoblast progenitor cells. The large surface area of the syncytiotrophoblast is necessary for transport functions while it also serves as the site of synthesis of hormones and steroids. Studies of syncytiotrophoblast transcription are puzzling, demonstrating that many of the nuclei in the multinucleated syncytium are transcriptionally inactive. To further elucidate RNA activity in the syncytiotrophoblast, we investigated expression of snRNAs involved in RNA splicing. Using RNA in situ hybridization, we observed that snRNAs were markedly reduced in the syncytium throughout the course of pregnancy. Recapitulating these results in primary trophoblasts and in trophoblast cell lines in vitro, we found, using qRT-PCR and RNA in situ hybridization, that snRNA expression is reduced in trophoblasts cultured under fusion conditions. Our finding that snRNA is markedly reduced in the syncytiotrophoblast suggests that the placenta has evolved a balance between the large surface area essential for its transport function and the need to regulate protein production in the multinucleated syncytium.
Regulation of plasma membrane homeostasis: Dissecting TORC2 signaling (2019)

Cell survival requires preservation of plasma membrane (PM) integrity in response to environmental insults and changes in lipid metabolism. In eukaryotic cells, maintenance of PM homeostasis requires a conserved, PM‐localized protein kinase complex, Target of Rapamycin (TOR) Complex 2 (TORC2). In budding yeast ( Saccharomyces cerevisiae ), the essential catalytic subunit of TORC2 is the TOR isoform Tor2 and the essential downstream effector of TORC2 is the AGC‐family protein kinase Ypk1 (and its paralog Ypk2). Our prior work has shown that Ypk1 phosphorylates and thereby regulates proteins that stimulate the rate of sphingolipid production, control the amount of glycerol‐3P available for glycerolipid biosynthesis, impede retrograde transport of sterols from the PM, and modulate the efficiency of clathrin‐mediated endocytosis of integral PM proteins. More recently, we have confirmed that Muk1, a Rab5‐specific guanine nucleotide exchange factor (GEF) we identified in a global screen for new Ypk1 targets, is a bona fide Ypk1 substrate whose GEF function is stimulated by Ypk1‐mediated phosphorylation. Our studies further show that TORC2‐ and Ypk1‐dependent activation of Muk1 provides a control circuit for positive (self‐reinforcing) Rab5‐mediated stimulation of TORC2 action. It has been presumed that three TORC2 subunits (Avo1, Slm1 and Slm2), which contain Pleckstrin Homology (PH) domains exhibiting specificity for phosphatidylinositol‐4,5‐ bis phosphate (PtdIns4,5P2), tether TORC2 at the PM. To investigate assembly and PM localization of TORC2, we used auxin‐inducible degradation and fluorescence microscopy of its constituent subunits to systematically examine the roles of these proteins and of PtdIns4,5P2 in TORC2 PM targeting. Contrary to prior assumptions, our findings pinpoint the essential subunit Avo3 (mammalian counterpart is RICTOR) as pivotal for TORC2 PM localization and assembly in vivo . However, how TORC2 activity is modulated in response to changes in the status of the cell envelope is unclear. In recent work, we found that TORC2 subunits Avo2 and Avo3 are direct targets of Slt2/Mpk1, the MAPK of the cell wall integrity pathway. Slt2‐mediated phosphorylation of Avo2 at its MAPK phosphoacceptor sites inhibits TORC2‐mediated activation of Ypk1. Deletion of Avo2 or expression of a phosphomimetic Avo2 allele rendered cells sensitive to two stresses (myriocin treatment and elevated exogenous acetic acid) that the cell requires Ypk1 activation by TORC2 to survive. Collectively, our studies have provided new insights about the assembly, localization, function and regulation of TORC2. Support or Funding Information Supported by Cancer Research Coordinating Committee Predoctoral Fellowship (to M.N.L.), a Schroedinger Fellowship from the Austrian government (to A.E.‐A.), by NIGMS Predoctoral Traineeship GM07232 (to K.L.L.), and by NIH R01 Research Grant GM21841 (to J.T.) . This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
FAULT-TOLERANT CHARACTERISTICS AND TOPOLOGICAL PROPERTIES OF A HIERARCHICAL NETWORK OF HYPERCUBES (1999)

We analyse the fault-tolerant parameters and topological properties of a hierarchical network of hypercubes. We take a close look at the Extended Hypercube (EH) and the Hyperweave (HW) architectures and also compare them with other popular architectures. These two architectures have low diameter and constant degree of connectivity making it possible to expand these networks without affecting the existing configuration. A scheme for incrementally expanding this network is also presented. We also look at the performance of the ASCEND/DESCEND class of algorithms on these architectures.
1H-n.m.r. studies of the isolated activation segment from pig procarboxypeptidase A (1990)

The isolated activation segment (asA) from pig pancreatic procarboxypeptidase A was studied by 1H-n.m.r. spectroscopy over a wide range of solution conditions. Isolated asA shows many characteristics of compactly folded globular proteins, such as the observation of perturbed positions for resonances from methyl groups, alpha-carbon atoms, histidine residues and the tyrosine residue. The single tyrosine residue (Tyr-70) exhibits a very high pKa, and both histidine and tyrosine residues show slow chemical modification (deuteration and iodination). In contrast, asA shows rapid NH exchange. Analysis of the spectra by pH titration and nuclear Overhauser effects revealed several residue interactions. Quantitative analysis of deuterium and tritium exchange allowed the assignment of the histidine C-2-H resonances to their respective residues in the sequence. His-66, the closest to the sites of proteolytic attack in the proenzyme, is shown to be the most accessible to solvent in procarboxypeptidase A. It was also shown that asA is thermally very stable ['melting' temperature (Tm) 88 degrees C] and requires a high urea concentration for denaturation (6.25 M, at pH 7.5). Evidence is presented for some degree of conformational flexibility in the premelting range, a feature that could be ascribed to the preponderance of helical secondary structure and to the lack of disulphide bridges. The free solution structure of asA is probably unchanged when it binds to carboxypeptidase A.
Quantum state control via tunneling in an optical potential (2003)

Summary form only given. The development of methods to manipulate and measure the quantum mechanical state of a physical system represents one of the great challenges of modern science. Examples of systems in which quantum control is sought or has been accomplished include trapped atomic ions, the electromagnetic field, Rydberg electrons, nuclear spins and vibrations in molecules, and chemical reactions. For many years a paradigm for quantum coherent evolution has been the occurrence of tunneling in macroscopic and mesoscopic double-well potentials. Much theoretical work has been done on this model system, but a series of fundamental questions remain to be addressed in well-controlled experiments, notably whether coherent evolution can be enforced in the presence of a noisy environment, by suitable perturbations of the state of the tunneling particle. The challenge is to find simple physical systems, which can be made to interact with a well characterized environment in a controlled manner.
Emerging oncogenic fusions other than ALK, ROS1, RET, and NTRK in NSCLC and the role of fusions as resistance mechanisms to targeted therapy (2020)

Recent evidence has shown that gene fusions caused by chromosomal rearrangements are frequent events in the initiation and during progression of solid tumors, including non-small cell lung cancers (NSCLCs). Since the discoveries of <i>ALK</i> and <i>ROS1</i> fusions in 2007 and the subsequent successes of pharmacological targeting for these fusions, numerous efforts have identified additional oncogenic driver fusions in NSCLCs, especially in lung adenocarcinomas. In this review, we will summarize recent advances in this field focusing on novel oncogenic fusions other than <i>ALK</i>, <i>ROS1</i>, <i>NTRK</i>, and <i>RET</i> fusions, which are summarized in other articles in this thematic issue. These novel gene fusions include <i>neuregulin-1</i> (<i>NRG1</i>) fusions, <i>MET</i> fusions, fusion genes involving <i>fibroblast growth factor receptor</i> (<i>FGFR</i>) family members, <i>EGFR</i> fusions, and other rare fusions. In addition, evidence has suggested that acquisition of gene fusions by cancer cells can be a molecular mechanism of acquired resistance to targeted therapies. Most of the current data are from analyses of resistance mechanisms to EGFR tyrosine kinase inhibitors in lung cancers with oncogenic <i>EGFR</i> mutations. However, a few recent studies suggest that gene fusions can also be a resistance mechanism to <i>ALK</i>-tyrosine kinase inhibitors in lung cancers with oncogenic <i>ALK</i> fusions. Detection, validation, and pharmacological inhibition of these fusion genes are becoming more important in the treatment of NSCLC patients.
Signal for DNA Methylation Associated with Tandem Duplication in <i>Neurospora crassa</i> (1987)

Most cytosine residues are subject to methylation in the zeta-eta (zeta-eta) region of Neurospora crassa. The region consists of a tandem direct duplication of a 0.8-kilobase-pair element including a 5S rRNA gene. The repeated elements have diverged about 15% by the occurrence of numerous CG to TA mutations, which probably resulted from deamination of methylated cytosines. Most but not all common laboratory strains of N. crassa have methylated duplicated DNA at the zeta-eta locus. However, many strains of N. crassa and strains of N. tetrasperma, N. sitophila, and N. intermedia have one instead of two copies of the homologous DNA and it is not methylated. A cross of strains differing at the zeta-eta locus produced progeny which all had duplicated, methylated, or unique, unmethylated DNA, like the parental strains. We conclude that a signal causing unprecedented heavy DNA methylation is present in the zeta-eta region.
Server Policies For Interactive Transmission Of 3D Scenes (2006)

We consider an interactive client-server application for remote browsing of 3D scenes. The information about texture and geometry is available at server side in the form of scalably compressed images and depthmaps, corresponding to a multitude of original image views. Image and depth components are both open to augmentation as more content becomes available. During the interactive browsing experience, the server allocates the available bandwidth between the delivery of new elements from the various original view bit-streams and new elements from the original geometry bit-streams. We propose a rate-distortion criterion to decide the best transmission policy for the server, since the best solution is not always to send the nearest original view image to the one which the client is rendering. We also outline how the JPIP standard for interactive transmission of JPEG2000 images can be exploited for remote exploration of 3D scenes
Thiazolo[4,3‐<i>c</i>][1,4]benzodiazepines. II. Synthesis of fused[<i>a</i>]triazolo, tetrazolo and oxadiazolo derivatives (1996)

Abstract We report the practical synthesis of the first fused[ a ]triazolo, tetrazolo and oxadiazolothiazolo[4,3‐c]‐[1,4]benzodiazepine‐5,11‐diones via hydrazidines and oximes.
Abstract A136: Proteome analysis reveals candidate genes regulated by BLID, a novel drug-inducible apoptotic target, in breast cancer cells. (2013)

Abstract BLID, BH-3 Like motif containing Inducer of cell Death, is a strong prognostic factor in invasive breast cancer (1). Frequent lack of BLID in breast cancer has been associated with triple-negative breast cancer (TNBC), African American ethnicity and younger women. Significant correlations exist between BLID negative breast cancer and declines in overall survival, local relapse-free survival and distant metastasis-free survival. In dose response and time course studies, BLID expression was found to be induced by chemotherapeutic drugs including doxorubicin, 5-fluorouracil and cisplatin in MCF-7 breast cancer cells. In addition, exogenous expression of BLID cDNA nanocomplex led to significant increase in chemosensitivity in SKBr3 (ER-ve/PR-ve) and MDA-MB231 (TNBC) breast cancer cell lines. Here we have investigated the effects of BLID knockdown on protein expression profiles in representative hormone responsive (MCF-7) and TNBC breast cancer cells (MDA-MB231) with a goal to identify a core translational component signifying BLID activity in breast cancer cells. BLID shRNA lentiviral particles were generated using pLKO.1-TRC containing BLID shRNA clone 47 according to the supplier's manual (Sigma-Aldrich). Breast cancer cells were stably transfected with BLID shRNA or scrambled shRNA. The pooled stable clones were tested for BLID expression by western blot analysis. Significant knockdown of BLID protein was achieved in breast cancer cells transfected with BLID shRNA (% inhibition of BLID expression vs. scrambled shRNA: MCF-7, 69%; MDA-MB231, 63%). The BLID proteome analysis was performed using antibody microarrays as we reported earlier (2). We have observed distinct and overlapping BLID-centric protein profiles in MCF-7 and MDA-MB231 cells. Among the top-ranked genes, BLID knockdown correlated with increased expression of PI3-kinase catalytic subunit α and DEK oncogene in MCF-7 cells, and increased expression of myeloid cell leukemia sequence 1 (MCL-1) in MDA-MB231 cells. Remarkably, BLID depletion correlated with decreased expression of tumor protein p73 and cAMP-dependent protein kinase (PKA Type Iα) in both cell lines. Thus, we have identified a working platform of genes signifying BLID expression in breast cancer cells. Validation of the top-ranked genes in various models of breast cancer is ongoing and data will be presented. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):A136. Citation Format: Sivaramakrishna Yadavalli, Ofer Eidelman, Meera Srivastava, Usha N. Kasid. Proteome analysis reveals candidate genes regulated by BLID, a novel drug-inducible apoptotic target, in breast cancer cells. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr A136.
Kinetic Analysis of the Hydrogenolysis of Lower Polyhydric Alcohols:  Glycerol to Glycols (2003)

The production of ethylene glycol and propylene glycol from higher polyhydric alcohols has been parametrically examined numerous times. However, efforts to develop improved catalyst systems require a better understanding of the reaction mechanism. Glycerol conversion to the glycols represents an initial system for developing an improved mechanistic understanding of the conversion of the more complex higher polyhydric alcohols. Batch reactor studies with ruthenium on carbon catalysts were performed at two pH levels to obtain kinetic data. Langmuir−Hinshelwood-type models were developed from the experimental data to describe the hydrogenolysis of glycerol into ethylene glycol and propylene glycol as well as further degradation of the glycols. Detailed information on the competitive adsorption coefficients for the reaction species was determined, which led to conclusions about the limitations of previous parametric analysis.
Observation of Shrinking and Reformation of Shockley Stacking Faults by PL Mapping (2006)

We provide evidence of shrinking of Shockley-type stacking faults (SSFs) in the SiC epitaxial layer by high temperature annealing. Photoluminescence (PL) mapping in combination with high-power laser irradiation makes it possible to investigate the formation of SSFs, which lie between a pair of partial dislocations formed by dissociation of a basal plane dislocation (BPD), without fabrication of pin diodes. Using this technique, we investigated the annealing effect on SSFs. Comparing before and after annealing at 600°C for 10 min, it became obvious that high-temperature annealing results in shrinking of the faulted area of the SSFs. The SSFs form into the same features as those before annealing when high-power laser irradiation is performed again on the same area. This result shows that the faulted area of SSFs shrinks by 600°C annealing but the nuclei of SSFs (BPDs) do not disappear.
Pump-wavelength dependence of FWM performance in semiconductor optical amplifiers (1997)

We report on experimental investigation of the dependence on pump-wavelength of efficiency and signal to background ratio of a wavelength converter based on four-wave mixing in a semiconductor optical amplifier (SOA). The signal wavelength has been varied over a 60-nm range at fixed signal-converted detuning. Both efficiency and background level increase by moving the operation wavelength toward bandgap. Nevertheless, we observe a variation of the signal to background ratio of only 2 dB in a 40-nm range. A qualitative interpretation of the results is presented.
MECHANISM OF CHEMICAL MUTAGENESIS IV (1961)

Lorkiewicz, Z. (University of Wisconsin, Madison), and Waclaw Szybalski. Mechanism of chemical mutagenesis. IV. Reaction between triethylene melamine and nucleic acid components. J. Bacteriol. 82: 195-201. 1961.-Triethylene melamine interacts primarily with phosphorylated intracellular deoxyribonucleic acid (DNA) precursors and not with DNA. It was found by direct chemical and chromatographic analysis that only pyrimidine precursors of nucleic acids are attacked by triethylene melamine. In the course of the triethylene melamine-deoxycytidine reaction the mutagenicity of the reaction mixture is lost, but the mutagenicity of the triethylene melamine-thymidine reaction products significantly increases above that of the reaction substrates. Several steps are postulated to explain the mechanism of the triethylene melamine-initiated mutagenic reaction: (i) Reaction I, semireversible uptake of triethylene melamine; (ii) reaction II, chemical interaction between triethylene melamine and intracellular thymidine mono- or triphosphate with the production of a functional analogue of the latter; (iii) incorporation of this fraudulent analogue into the newly formed DNA strand; (iv) occurrence of self-perpetuating errors in the sequence of natural bases during subsequent rounds of replication of the analogue-containing DNA strand. It is postulated that the mechanism of mutagenic responses to different types of mutagens can fit either a simplified (mutagenic base analogues) or extended version (radiation) of this schema.
CAN'T TOUCH THAT? POSSIBLE SOLUTIONS TO THE PROBLEMS OF SOVEREIGN IMMUNITY ATTACHING TO THE SUNKEN WARSHIPS OF CHUUK LAGOON (2014)

Due to corrosion, fifty-two sunken World War II era Japanese warships are poised to cause an environmental disaster in the Federated States of Micronesia. As the ships sunk on government non-commercial service sovereign immunity attaches to the wrecks. This potentially prevents the Federated States of Micronesia or any commercial salvor from being able to remove the hazardous cargo. The doctrine of necessity found in the International Law Commission’s Draft Articles on State Responsibility for Internationally Wrongful Acts can be invoked to protect an ‘essential State interest’ and the Federated States of Micronesia should act to protect its natural environment despite Japan’s claim to sovereign immunity. The feasibility of any salvage operation is questionable though, given both national and international impediments to the salvage of warships. The article will lastly consider why, despite requests, Japan may have been unwilling to render assistance.
High-Resolution Fourier transform spectrometer to identify the rotational structure of the B2.SIGMA.u+-X2.SIGMA.g+ transition of N2+(0,0) in a helium inductively coupled plasma (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-Resolution Fourier transform spectrometer to identify the rotational structure of the B2.SIGMA.u+-X2.SIGMA.g+ transition of N2+(0,0) in a helium inductively coupled plasmaThomas J. Manning, Byron A. Palmer, and Douglas E. HofCite this: Anal. Chem. 1989, 61, 9, 1052–1056Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ac00184a027https://doi.org/10.1021/ac00184a027research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts