gebhart/patrepeval huggingface dataset:
[Treatment of endometriosis. Evaluation of preoperative therapy with danazol, gestrinone and buserelin (nasal spray and implant)]. (1990)

In order to adequately assess the effectiveness of danazol, gestrinone, buserelin-nasal spray (IN) and buserelin-implant (SC), a prospective non randomized study was initiated in 178 patients with laparoscopically confirmed ovarian endometriosis. After hormonal therapy, laparotomy with microsurgical resection of endometriotic cysts or laparoscopy laser was carried out. Regression (greater than 25%) of ovarian endometriosis was noted in 30, 34, 73 and 91% of cases after danazol, gestrinone and buserelin IN and buserelin SC respectively. Histological study proves that hormonal treatment leads to an incomplete suppression of ovarian endometriotic implants and this suggests the necessity to remove surgically invasive ovarian endometriosis. The pregnancy rate in moderate endometriosis (55%) differed significantly from the rate obtained in severe endometriosis (44%). The highest percentages were found after buserelin therapy. In conclusion, preoperative use of a potent GnRH agonist, administered subcutaneously, seems to be the best therapeutic approach when associated to surgery (CO2 laser or microsurgery).
Characterization of carbon-supported ruthenium–tin catalysts by high-resolution electron microscopy (1994)

Ruthenium and bimetallic ruthenium–tin catalysts supported on high-surface-area carbon are characterized by high-resolution electron microscopy (HREM) and CO chemisorption. The characterization results give important insights into the reasons for the remarkable catalytic properties of Ru–Sn bimetallic catalysts in selective hydrogenation reactions of α,β-unsaturated aldehydes. In the monometallic Ru/C sample, ruthenium is present as small particles, showing no variation in the crystalline structure and lattice parameters with respect to the bulk state. At low Sn : Ru ratios, the average metal particle size is smaller than for monometallic Ru/C, whereas at higher Sn: Ru ratios Ru particles agglomerate on the surface of the support. According to HREM observations, most metal particles in the bimetallic catalysts possess a structure consistent with that of elemental ruthenium. CO chemisorption results indicate that the surface of the ruthenium particles is partially covered by tin species. Only in the samples with high tin loading are a few Ru–Sn only particles found, in addition to a majority of particles having the structure of pure ruthenium. The high selectivity of Ru–Sn/C catalysts for selective hydrogenation of the CO group in α,β-unsaturated aldehydes can thus be attributed to the presence of small ruthenium particles whose surface is covered with tin species which are most likely in ionic form. Ru–Sn alloy particles do not appear to make a significant contribution to the catalytic activity.
Extraction of Metal Thiocyanate Complexes with Tributyl Phosphate (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtraction of Metal Thiocyanate Complexes with Tributyl PhosphateL. M. Melnick and Henry FreiserCite this: Anal. Chem. 1955, 27, 3, 462–463Publication Date (Print):March 1, 1955Publication History Published online1 May 2002Published inissue 1 March 1955https://pubs.acs.org/doi/10.1021/ac60099a046https://doi.org/10.1021/ac60099a046research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improving traffic incident management: literature review (2007)

It could be argued that literature on traffic incident management seemed to fall into two categories; one associated with the management of traffic incident management programs and the other associated with enabling technologies such as detection and modelling. It can be concluded from the available material that the literature on management issues originate mainly from practitioners and consultants who facilitate these managerial processes as well as having to deal with the actual on site management of traffic incidents, while the technological issues of traffic management are researched by academics. As such, practitioners have to deal with management of operational activities, institutional relationships and also make decisions on technological issues involving incident detection, resources for clearance and recovery, traffic management and information dissemination to the public. The intended end users of this report include organisations responsible for road traffic and transport, police, national and state security organisations, fire and rescue services, ambulance, road and traffic service providers, response towing and recovery providers, and organisations responsible for environmental monitoring and hazardous materials. Education and research institutions would also benefit. (a)
Deficient IL-12(p35) Gene Expression by Dendritic Cells Derived from Neonatal Monocytes (2001)

To gain insight into the defects responsible for impaired Th1 responses in human newborns, we analyzed the production of cytokines by dendritic cells (DC) derived from cord blood monocytes. We observed that neonatal DC generated from adherent cord blood mononuclear cells cultured for 6 days in the presence of IL-4 and GM-CSF show a phenotype similar to adult DC generated from adherent PBMC, although they express lower levels of HLA-DR, CD80, and CD40. Measurement of cytokine levels produced by neonatal DC upon stimulation by LPS, CD40 ligation, or poly(I:C) indicated a selective defect in the synthesis of IL-12. Determination of IL-12(p40) and IL-12(p35) mRNA levels by real-time RT-PCR revealed that IL-12(p35) gene expression is highly repressed in stimulated neonatal DC whereas their IL-12(p40) gene expression is not altered. The addition of rIFN-gamma to LPS-stimulated newborn DC restored their expression of IL-12(p35) and their synthesis of IL-12 (p70) up to adult levels. Moreover, we observed that neonatal DC are less efficient than adult DC to induce IFN-gamma production by allogenic adult CD4(+) T cells. This defect was corrected by the addition of rIL-12. We conclude that neonatal DC are characterized by a severe defect in IL-12(p35) gene expression which is responsible for an impaired ability to elicit IFN-gamma production by T cells.
<title>Low-power cholesteric LCDs and electronic books</title> (2004)

We discuss the state of the art of the bistable reflective cholesteric liquid crystal display technology. Numerous applications from low resolutions signs, to medium resolution instrumentation type displays, and high resolution electronic books are discussed. Different modes of the technology are discussed as being viable for the respective display applications. Special emphasis is paid to electronic book applications.
Crystal Structure of a Human Single Domain Antibody Dimer Formed through VH-VH Non-Covalent Interactions (2012)

Single-domain antibodies (sdAbs) derived from human V(H) are considered to be less soluble and prone to aggregate which makes it difficult to determine the crystal structures. In this study, we isolated and characterized two anti-human epidermal growth factor receptor-2 (HER2) sdAbs, Gr3 and Gr6, from a synthetic human V(H) phage display library. Size exclusion chromatography and surface plasmon resonance analyses demonstrated that Gr3 is a monomer, but that Gr6 is a strict dimer. To understand this different molecular behavior, we solved the crystal structure of Gr6 to 1.6 Å resolution. The crystal structure revealed that the homodimer assembly of Gr6 closely mimics the V(H)-V(L) heterodimer of immunoglobulin variable domains and the dimerization interface is dominated by hydrophobic interactions.
Thyroid Function and the Cardiac Disposition of Catecholamines (1963)

Hyperthyroid rats show an elevated and prolonged hemodynamic response to injected epinephrine; hypothyroid rats have lower base-line blood pressures than control animals, but show a normal response to the catecholamine. Hyperthyroid rats shunt a larger fraction of the cardiac output to their enlarged hearts, thus delivering a greater proportion of a dose of H3-epinephrine to this organ. Each gram of hyperthyroid heart receives the same fraction of circulating H3-epinephrine as an equal weight of normal heart, but its capacity to inactivate the H3-epinephrine by binding is diminished. The consequent maintenance of elevated levels of free epinephrine may be a major factor in the development of the altered hemodynamic response of the hyperthyroid animal to epinephrine. A single large dose of thyroxine has no effect on the uptake, binding or release of H3- epinephrine by the heart, or the hypertensive response induced by a given dose of the neurohumor. Hypothyroid hearts receive and bind as much circulating epinephrine as normal hearts, in spite of their decreased weight. One hour after H3-epinephrine administration they contain greater amounts of the H3-metabolites, while hyperthyroid hearts contain smaller quantities. This difference is probably related to washout by the circulating blood. Although hyperthyroidism increases hepatic monoamine oxidase activity in the female, and hypothyroidism decreases it in the male, hyperthyroidism is associated with a decrease and hypothyroidism with an increase in deaminated metabolites of H3-epinephrine in the heart. Neither cardiac nor hepatic catechol-Omethyl transferase activity is altered by doses of thyroxine which produce hyperresponsiveness to epinephrine. It is concluded that at least a part of the mechanism of the increased cardiovascular sensitivity to epinephrine found in hyperthyroidism is not due to changes in the activities of the enzymes which metabolize epinephrine, but is related to a decreased ability of each unit weight of heart to inactivate this catecholamine by binding. More “free” epinephrine is available in the heart to act on its physiologic receptors.
A novel human hepatoma cell line, FLC‐4, exhibits highly enhanced liver differentiation functions through the three‐dimensional cell shape (2011)

We characterized three-dimensional human hepatoma cell lines, functional liver cell (FLC) cell lines, to establish a highly differentiated hepatoma cell line. We investigated the effect of extracellular matrix and cell morphology on liver-specific gene expression in FLC cells. The hepatocyte nuclear factor-4α (HNF-4α) and other liver-specific gene expressions were enhanced in spherical FLC-4 cells on EHS-gel, but other human hepatoma cells such as HepG2 did not show the enhancement. Importantly, the liver-specific gene expression levels in spherical FLC-4 cells cultured on EHS-gel were comparable to those of human liver and were much higher than those of other human hepatoma cell lines. The major matrix components and growth factors in EHS-gel did not affect cell shape and liver functions. To exclude any effect of the extracellular matrix, we made spherical FLC-4 cells by actin filament disruption. The actin-disrupted spherical cells also showed an enhanced liver-specific gene expression. We concluded that three-dimensional cell shape per se is one of the most important determinants of liver differentiation functions in FLC-4 cells. Cell morphology-dependent induction of liver-specific gene expression was mediated through microtubule organization. In conclusion, differentiation of FLC-4 human hepatoma cell line can be enhanced to a human liver-like level through the three-dimensional cell shape in a microtubule-dependent manner.
ChemInform Abstract: Difunctionalized Oxirane Systems. Stereodivergent Synthesis of 1,4;2,3‐ Dianhydro‐5‐O‐benzyl‐L‐lyxitol and ‐L‐ribitol. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Substituted Indazoles as Na<sub>v</sub>1.7 Blockers for the Treatment of Pain (2016)

The genetic validation for the role of the Nav1.7 voltage-gated ion channel in pain signaling pathways makes it an appealing target for the potential development of new pain drugs. The utility of nonselective Nav blockers is often limited due to adverse cardiovascular and CNS side effects. We sought more selective Nav1.7 blockers with oral activity, improved selectivity, and good druglike properties. The work described herein focused on a series of 3- and 4-substituted indazoles. SAR studies of 3-substituted indazoles yielded analog 7 which demonstrated good in vitro and in vivo activity but poor rat pharmacokinetics. Optimization of 4-substituted indazoles yielded two compounds, 27 and 48, that exhibited good in vitro and in vivo activity with improved rat pharmacokinetic profiles. Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days.
Providing privacy on the tuple space model (2017)

Conceptually, tuple spaces are shared memory objects that provide operations to store and retrieve ordered sets of data, called tuples. Tuples stored in a tuple space are accessed by the contents of their fields, working as an associative memory. Although there are some proposals for secure tuple spaces, accessing tuples through field contents makes these systems susceptible to attacks that could impair user and data privacy, since servers must access tuple data. In order to deal with these limitations and provide privacy in the tuple space model, this paper proposes some extensions to DepSpace, a tuple space system that implements dependability and security properties through a set of mechanisms that are not enough to ensure privacy. The resulting system provides privacy and, at the same time, allows tuple selection/matches similar to the traditional insecure model, i.e., it does not constraint the matching possibilities. The main problem to be addressed is that servers must select tuples based on their contents without knowing them. The proposed solution uses robust cryptographic schemes, as order-preserving encryption and homomorphic encryption, to provide this functionality without revealing the tuple contents. An analysis concerning security aspects of DepSpace is presented, as well as the benefits of the proposed solutions. A set of experiments, executed with an implementation of the proposed protocols, shows the feasibility of the proposed solutions and shed some light on both the behavior of the system and the costs to provide privacy in the tuple spaces model.
Methodologies for Generating Solution-Phase Combinatorial Libraries (2000)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethodologies for Generating Solution-Phase Combinatorial LibrariesHaoyun An and P. Dan CookView Author Information Isis Pharmaceuticals, Incorporated, 2292 Faraday Avenue, Carlsbad, California 92008 Cite this: Chem. Rev. 2000, 100, 9, 3311–3340Publication Date (Web):July 20, 2000Publication History Received14 September 1999Published online20 July 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/cr990014rhttps://doi.org/10.1021/cr990014rresearch-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1099Altmetric-Citations116LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amines,Mixtures,Purification,Reaction products,Scaffolds Get e-Alerts
Werner F. Leopold, <i>Speech Development of a Bilingual Child</i>, Vol. II: <i>Sound-learning in the First Two Years</i> (1950)

(1950). Werner F. Leopold, Speech Development of a Bilingual Child, Vol. II: Sound-learning in the First Two Years. The Germanic Review: Literature, Culture, Theory: Vol. 25, No. 2, pp. 131-133.
Real time ultrafast spectroscopy of shock front pore collapse (2001)

Shock-wave induced nanopore collapse (average diameter 100 nm) at 4.2 GPa in a 3-μm-thick poly-methyl methacrylate (PMMA) layer is measured in real time using coherent anti-Stokes Raman spectroscopy (CARS). Pore collapse is monitored via CARS transitions of a dye probe embedded in the porous medium. A pore collapse time constant of 3 ns in PMMA is in poor agreement with hydrodynamic pore collapse models but in excellent agreement with a viscoplastic model that uses the “shock viscosity” determined from the PMMA viscoelastic response to shock. The shock viscosity is more than 12 orders of magnitude smaller than the ordinary viscosity. A downstream gauge of polycrystalline anthracene monitors changes in the steeply rising shock front (&lt;25 ps rise time) after passing through the porous medium or a scattering medium with 100-nm-diam scatterers. The anthracene is a two-dimensional (2D) shock gauge that provides a time sequence of CARS spectra S(t,λ). The 2D gauge is shown to be capable of discriminating between a shock front that gradually rises with time constant tr or a bunch of steeply rising shocklets with an arrival time spread equal to tr. The transmitted shock front is shown to consist of a bunch of steep shocklets with an arrival time spread of 550 ps.
Niobium Oxide Thin Films Grown by Atomic Layer Epitaxy (1998)

Nb2O5 thin films were grown by atomic layer epitaxy (ALE) in the temperature range of 150–350°C using Nb(OC2H5)5 and H2O as precursors. All the films grown on glass substrates were amorphous, as indicated by X-ray diffraction analysis. The films exhibited smooth surfaces as observed by scanning electron microscopy and uniform thickness profiles with less than 7% variation in the gas flow direction. The refractive index of the films increased with deposition temperature, stabilizing at 2.4 at temperatures higher than 230°C. Backscattering spectrometry analysis indicated that the films were stoichiometric Nb2O5.
Microbial Deracemization of 1-Aryl and 1-Heteroaryl Secondary Alcohols (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTMicrobial Deracemization of 1-Aryl and 1-Heteroaryl Secondary AlcoholsGraham R. Allan and Andrew J. CarnellView Author Information Department of Chemistry, Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, U.K. [email protected]Cite this: J. Org. Chem. 2001, 66, 19, 6495–6497Publication Date (Web):August 23, 2001Publication History Received18 May 2001Published online23 August 2001Published inissue 1 September 2001https://pubs.acs.org/doi/10.1021/jo015770nhttps://doi.org/10.1021/jo015770nbrief-reportACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1248Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Ethanol,Ketones,Peptides and proteins,Redox reactions Get e-Alerts
Role of Cyclic AMP in Mitogen Induced Transformation of Human Peripheral Leukocytes (1973)

Abstract Phytohemagglutinin (PHA) causes a stimulation of the adenyl cyclase activity of human peripheral leukocytes within 15 min of incubation of cells with the mitogen. An increase in the intracellular content of cyclic 3′,5′-adenosine monophosphate (cAMP) was also observed in purified lymphocyte preparations. The blast transformation and the stimulation of the adenyl cyclase by PHA are dose dependent; excessive concentration of the mitogen is inhibitory for both effects. A variety of pharmacological agents (propranolol; chlorpromazine and imidazole) that interfere with the PHA induced activation of adenyl cyclase or that lower the intracellular levels of cAMP at the early stages inhibit also the blast transformation as measured by the incorporation of 3H-thymidine into DNA on the day of peak response. cAMP however does not simulate fully the mitogenic action of PHA. When added to the medium, a maximal stimulation of about 2- to 3-fold over the basal control value is obtained which is far lower than the transformation with PHA (450-fold). Dibutyryl cAMP, cyclic 3′,5′-guanosine monophosphate and cyclic 3′,5′-cytidine monophosphate were ineffective in the induction of transformation. Moreover, another potent mitogen, concanavalin A, gives only a marginal activation of adenyl cyclase and a moderate increase in intracellular cAMP levels in the initial phases. It is concluded that activation of adenyl cyclase and a rise in intracellular content of cAMP in the early phase are possibly a part (but not all) of the initial effects of PHA on human leukocytes.