gebhart/patrepeval huggingface dataset:
Network controlled adaptive antenna tilting in multi-band UMTS FDD (2005)

This work proposes an adaptive antenna tilting approach in an overlay UMTS FDD network. The purpose is to introduce and investigate an antenna element, which can be remotely controlled by the radio network, in order to adequately cater for the spatial and temporal dynamic traffic distributions. The tilting angle is computed by a two level control mechanism: the higher level is controlled by the network manager and consists of a look-up table with the possible ranges (intervals or discrete steps for angles) of the antenna angle adjustments. The element manager, e.g. RNC controlling and recording the track of the dynamic antenna changes, controls the lower level. To enhance the system reliability, we associate the less dynamic traffic with the primary fixed tilt antenna, whereas the more varying traffic is controlled by a second more dynamically tilted antenna element. Through system level simulations, we show that significant gains in term of system capacity can be obtained. In addition, solutions involving the network management subsystem in UMTS FDD are also given, where the element management platform interacts with the performance measurement units. Intelligent inter-frequency handovers are deliberately discussed.
IC–P–099: Automated medial Temporal Lobe Atrophy Scale (ATLAS): Application to Alzheimer's disease (2006)

The Hippocampus (Hc) is one of the earliest sites of pathology in Alzheimer's disease (AD). Volumetric MRI–based measures of Hc atrophy have been proposed as biomarkers of AD and as outcome measures in trials incorporating serial MRI. However, these measurements are laborious and subject to operator variability. In addition, atrophy invariably extends beyond the Hc to involve neighboring structures and is associated with enlargement of adjacent cerebrospinal fluid spaces. Visual rating scales of medial temporal atrophy, which take into account atrophy not only of Hc but also neighboring structures, appear to be useful diagnostic tools. However, they were not designed to measure progression using serial scanning. To compare a simple automated technique for measuring medial temporal lobe atrophy and progression of atrophy, with established visual rating scales and manual measures of Hc atrophy in AD. Volumetric T1–weighted MRI scans were obtained on thirty–seven AD patients and eighteen age–matched controls at baseline and one–year later. Three measures of medial temporal atrophy were compared: 1) total Hc volume measured manually and adjusted for total intracranial volume, 2) Scheltens' visual rating scale, and 3) a novel Automated medial Temporal Lobe Atrophy Scale (ATLAS), derived from dividing the mean intensity of a standardized Hc region by that of a standardized pontine region. AD patients had significantly reduced adjusted total Hc volume and ATLAS score, and increased Scheltens' score at baseline (4131±685 vs 5504±487 mm3, p<0.0001; 0.70±0.05 vs 0.77±0.04; p<0.0001; 2.2±0.7 vs 0.7±0.6; p<0.0001 respectively) and repeat scanning (3947±709 vs 5482±482 mm3, p<0.0001; 0.68±0.05 vs 0.76±0.04, p<0.0001; 2.4±0.7 vs 0.9±0.5, p<0.0001 respectively). Compared with controls, AD patients had significantly higher rates of total Hc atrophy and ATLAS score decline, but not in change on the Scheltens' score (4.02±2.60 vs 0.27±0.93 %/y, p<0.0001; 2.78±1.90 vs 0.58±1.59 %/y, p<0.0001, 0.15±0.41 vs 0.19±0.42 points/y, p=0.7 respectively). ATLAS scores were significantly correlated with both detailed volumetric measurements of Hc and visual rating scores at baseline and repeat scanning. ATLAS is an automated medial temporal atrophy measure that may prove to be a simple marker of AD and of AD progression in clinical trial settings.
Longitudinal changes in patient-reported outcome measures following total hip arthroplasty and predictors of deterioration during follow-up (2019)

The present study finds that patient factors affect the improvement and deterioration in PROMs over the medium term following THA. Special attention should be given to patients with risk factors for decreased PROMs, both preoperatively and during follow-up. Cite this article: <i>Bone Joint J</i> 2019;101-B:768-778.
Wearable and flexible pedobarographic insole for continuous pressure monitoring (2013)

The feedback of the foot plantar pressure is important in gait and posture application for diagnosing lower limb problems, injury prevention and motor relearning therapy as well as for footwear design and sport biomechanics. Tracking the pressure that acts between the foot and the support surface during everyday locomotor activities is clinically imperative to evaluate the foot function and in particular to assist patients with musculoskeletal and neurological diseases in the development of normal gait functionality. Here a flexible piezoresistive insole with dedicated electronics was developed to measure both the pressure distribution under 64 nodes arranged in the main plantar regions and the mean plantar pressure during walking activity with a sampling frequency of 20 Hz. This study reports on the easy and cost effective approach used to fabricate the conformable insole based on a piezoresistive material composed by copper spiky microparticles dispersed into silicon rubber. The entire insole was prepared in a single step by casting technique, and then completed with a patterned metalized polyimide films as bottom and top electrodes. The insole was then connected to a dedicated electronics to register the dynamic resistance variation under the plantar pressure. A connected personal computer was used for data analysis and visualization through a developed pressure imaging 3D software. The confidence on the obtained data allows the use of such piezoresisitve insole as a therapeutic or rehabilitative tool.
Atmospheric pressure chemical ionization multi-stage mass spectrometry in the characterization of stereoisomeric synthons of cyclopropane amino acids (2000)

The mass spectrometric behaviour of (1S,2R)-, (1R,2R)-, (1R,2S)- and (1S,2S)-2-[(S)-2,2-dimethyl-1, 3-dioxolan-4-yl]-1-spiro-¿4'[2'-phenyl-5'(4'H)-oxazolone]¿ cyclopropane (2) and (1S,2R)-, (1R,2R)-, (1R,2S)- and (1S, 2S)-methyl-1-benzamido-2-[(S)-2,2-dimethyl-1, 3-dioxolan-4-yl]cyclopropanecarboxylate (3) was studied under atmospheric pressure ionization conditions and by multi-stage mass spectrometric (MS(n)) experiments performed with an ion trap. Interestingly, by using methanol as solvent, compounds 2 lead to [M + H + CH(3)OH](+) ions which, as proved by collisional experiments, exhibit the same structure of the corresponding compound 3. MS/MS of [MH](+) ions allows a clear characterization of the different stereoisomers, which give rise to specific fragmentation pathways, rationalized with respect to the structure of the neutral molecules.
BTH1677 in combination with cetuximab with and without irinotecan in patients with advanced metastatic colorectal cancer (2016)

Aim: Investigate the safety, pharmacokinetics (PK) and efficacy of BTH1677/cetuximab, with and without irinotecan, in patients with metastatic colorectal cancer (mCRC). Patients & methods: Patients with recurrent or progressive mCRC were assigned to BTH1677/cetuximab/irinotecan (group 1; n = 10) or BTH1677/cetuximab (group 2; n = 22). Adverse events, PK parameters and tumor response were assessed. Results & conclusion: Adverse events were consistent with those expected of the backbone therapy of cetuximab/irinotecan (group 1) or cetuximab alone (group 2). The BTH1677 PK profiles were similar in the two groups. The overall response rates were 30.0% (group 1) and 22.7% (group 2); in KRAS wild-type subset analysis, rates were 42.9% and 45.5%, respectively. BTH1677 therapy was tolerable and warrants further evaluation for treatment of mCRC.
Screening dengue viral response genes for antiviral activity (2012)

Background: The identification of antiviral response signature genes and the discovery of crucial virus-host interactions will lead to a better understanding of the molecular mechanisms underlying viral pathogenesis. It contributes to the advancement of disease prognosis assessment and therapeutic innovation. The cellular factors that mediate defenses against viruses are complex and include products of interferon type I and II stimulation; stimulation of pathogen recognition receptors and their signaling; biochemical protein modifications such as ISGylation and ubiquitination; increased metabolic output, miRNA regulation and other cellular responses like apoptosis and growth regulation. Methods: To begin studying the overall cell and tissue response to viruses, we employed mRNA profiling of infected cells. The cell system utilized consisted of primary human myoblasts cells that are able to sustain a robust innate immunity response to dengue virus. Among the differentially expressed genes analyzed there were some that were discovered to be responsible, alone or in combination, for halting virus spread. But great majority of the gene expression response remains unexplored until now. We designed reverse genetic strategies as an approach to test antiviral activity and for functional identification of cell-specific antiviral proteins. Results: The shRNA screen consisted of 75 genes selected for the un-bias gene expression analysis for which 5 independent hairpins were designed. The high throughput screen was facilitated by novel luciferase-expressing dengue virus, providing a rapid and effective way to define host factors that impact the production of viral progeny. Conclusion: The results presented here provide unique information regarding dengue virus control and possible novel therapeutic mechanisms for elimination of pathogenic viruses in the human body.
Photodecomposition of Water Catalyzed by Zr- and Ti-MCM-41 (2003)

Experimentally incorporated Zr or Ti into the framework of MCM-41 could enhance the photocatalytic decomposition of H2O to H2. The hydrogen yield, for instance, on Zr-MCM-41 was about 7 mmol H2/hr-gZrO2. The enhancement of Zr-MCM-41 was over 80 times if compared to the bulk ZrO2. The Ti-MCM-41 also possessed an enhancement of about 17 times for the H2 yield (over TiO2).
Stardust backshell and back interface plate design verification tests in the NASA Ames Arc Jet facilities (1997)

This paper presents the results of the design verification tests for the SLA-561V backshell and back interface plate (BIP) of the Stardust Discovery Class Mission Sample Return Capsule (SRC). The Stardust spacecraft will fly by Comet Wild-2, collect cometary and interstellar dust and return them back to earth in the SRC at the fastest earth re-entry to date. The SLA-561V material, manufactured by Lockheed Martin Michoud, will be used on the backshell and BIP of the SRC. The cometary particles and interstellar dust will be collected in a tray filled with the novel aerogel material, which will be designed and built by the Jet Propulsion Laboratory (JPL). The SRC is designed as a clamshell to allow the extension of the aerogel tray during the collection period. The SRC clamshell will remain open for several years and then close and seal before re-entry to earth. Therefore, it is important to test the seal design of the joint between the PICA forebody and the SLA-561V backshell. The verification tests were performed in three NASA Ames Arc Jet facilities. The objectives were to verify designs of the seal and several penetrations in the backshell and BIP, such as the vents, electrical cable interface, the pushoff pad, and the attachment point, at the predicted peak heat flux and heat load conditions.
Social networking in vehicles (2006)

Thesis (S.M.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2006.
Electrophilic addition of thioselenophosphinic acids to vinyl sulfides and selenides (2015)

AbstractThe thioselenophosphinic acids, R2P(Se)SH (R = Ph, Cy, aralkyl), prepared by acidification of the sodium salts or generated in situ by reaction of secondary phosphine sulfides with elemental selenium, add easily to diverse vinyl sulfides and vinyl selenides in a Markovnikov manner to give the corresponding S- and Se-esters in a ∼60:40 molar ratio (83–96% total yield).Keywords: vinyl sulfidesvinyl selenidessecondary phosphine sulfidesthioselenophosphinic acidsaddition
Expression of p57KIP2 in hepatocellular carcinoma: relationship between tumor differentiation and patient survival (2002)

Cyclins, cyclin-dependent kinases (CDK), and CDK inhibitors (CKI) are frequently altered in neoplasm. p57(KIP2) is a member of the KIP (kinase inhibitory protein) family of CKI and is a potential tumor suppressor gene. p27(KIP1) is the most extensively studied KIP family member with respect to the clinical significance in human neoplasms. However, the clinical significance of p57(KIP2) expression in patients with human cancers, including hepatocellular carcinoma (HCC), remains unknown. This study examined whether p57(KIP2) expression has any impact on clinical behavior of HCC including prognosis. We examined an expression of p57(KIP2) by immunohistochemistry in 101 cases of various liver diseases, including 59 HCC. The p57(KIP2) expression in HCC was analyzed in association with the pathohistologic stage, differentiation, proliferating cell nuclear antigen (PCNA) expression status and several histopathologic factors of possible prognostic value, and patient survival. Immunohistochemical analysis revealed the frequent loss of p57(KIP2) in HCC, especially in moderately and poorly differentiated HCC. By Kaplan-Meier analysis, overall survival was significantly correlated with p57(KIP2) expression and PCNA, and multivariate analysis showed p57(KIP2) was an independent prognostic factor. When the status of p57(KIP2) and PCNA were combined, cases positive for p57(KIP2) and with a low expression of PCNA had a significantly better prognosis than those negative for p57KIP2 and/or with a high expression of PCNA. These data indicate that loss of p57(KIP2) is a frequent event in HCC, especially in poorly differentiated HCC, suggesting that p57(KIP2) might play a role in the differentiation of HCC. In addition, p57(KIP2) expression status is an independent prognostic factor for patients with HCC, and the loss of p57(KIP2) is correlated with poor prognosis. New therapeutic options might be provided by the combination of the loss of p57(KIP2) and expression of PCNA.
QR code localization using deep neural networks (2014)

Usage of computer-readable visual codes became common in our everyday life at industrial environments and private use. The reading process of visual codes consists of two steps, localization and data decoding. This paper introduces a new method for QR code localization using conventional and deep rectifier neural networks. The structure of the neural networks, regularization, and training parameters, like input vector properties, amount of overlapping at samples, and effect of different block sizes are evaluated and discussed. Results are compared to localization algorithms of the literature.
A system for acquiring physiological and environmental telemetry data (1987)

Paediatric phaeochromocytomas and paragangliomas (PPGLs), though rare tumours, are associated with significant disability and death in the most vulnerable of patients early in their lives. However, unlike cryptogenic and insidious disease states, the clinical presentation of paediatric patients with PPGLs can be rather overt, allowing early diagnosis, granted that salient findings are recognized. Additionally, with prompt and effective intervention, prognosis is favourable if timely intervention is implemented. For this reason, this review focuses on four exemplary paediatric cases, succinctly emphasizing the now state-of-the-art concepts in paediatric PPGL management.
Electron-Hop-Funnel Measurements and Comparison With the Lorentz-2E Simulation (2010)

Electron hop funnels have been fabricated using a low-temperature cofired ceramic. The measurements of the hop-funnel I-V curve and electron energy distribution have been made using gated field emitters as the electron source. The charged particle simulation Lorentz 2E has been used to model the hop-funnel charging and to predict the - and energy characteristics. The results of this comparison indicate that the simulation can be used to design hop-funnel structures for use in various applications.
Low-pass differentiators for biological signals with known spectra: application to ECG signal processing (1990)

Digital low-pass filtering and differentiation (LPD) are useful in real-time processing of many biomedical signals. A general method is presented for determining the coefficients of a differentiator that maximizes the signal-to-noise ratio or minimizes the error between actual and ideal LPD filters, when signal and noise spectra are known. Several examples of digital filters suitable for QRS complex and P-T wave processing in ECG are presented.
Vinconate prevents ischemic neuronal damage in the rat hippocampus (2009)

The neuroprotective effect of vinconate, a novel vinca alkaloid derivative, was examined in a rat model of forebrain ischemia induced by 4-vessel occlusion. Hippocampal cell loss was quantified histologically 3 days after 10 or 15 min of ischemia. Intraperitoneal application of vinconate (25 and 50 mg/kg) 10 min before and immediately after 10 min of ischemia significantly reduced the neuronal cell loss in the CA1 sector of the hippocampus. Protective effect of vinconate against 15 min of ischemia was reduced, but there was still significant protection at the higher dose. Autoradiography using 14C-vinconate showed that the drug easily penetrates the blood-brain barrier and distributes in the hippocampus. The result suggests that vinconate prevents ischemic neuronal damage by direct action on the hippocampal CA1 neurons.
Foreword: contemporary issues in the management and treatment of atrial fibrillation (2005)

This supplement represents the first publication of Thrombosis Quorum (TQ), a recently established international consortium of multidisciplinary thrombosis-related specialists dedicated to raising the priority of thrombosis. TQ aims to address the unmet clinical needs in the prevention and treatment of thromboembolic conditions, and promote the optimum management of patients with or at risk of these disorders by providing a cross-disciplinary forum for information exchange and debate. This publication incorporates a collection of state-of-the-art articles written by the TQ Steering Group and co-authors, and in this instance, focuses on the management and treatment of patients with atrial fibrillation (AF).

AF is the strongest independent predictor for stroke, the leading cause of disability, and the second leading cause of death worldwide. As such, AF has become accepted as a common and rapidly growing clinical problem and disease entity, as highlighted in the first article of this series by Bernard Gersh and coworkers who describe AF as a ‘growing epidemic’ and ‘an enormous public-health burden’. Although AF is primarily a disease of the elderly, the authors suggest that in most patients, the development of AF may …
On Achieving Local View Capacity Via Maximal Independent Graph Scheduling (2011)

“If we know more, we can achieve more.” This adage also applies to communication networks, where more information about the network state translates into higher sum-rates. In this paper, we formalize this increase of sum-rate with increased knowledge of the network state. The knowledge of network state is measured in terms of the number of hops, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">h</i> , of information available to each transmitter and is labeled as <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">h</i> -local view. To understand how much capacity is lost due to limited information, we propose to use the metric of normalized sum-capacity, which is the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">h</i> -local view sum-capacity divided by global-view sum capacity. For the cases of one and two-local view, we characterize the normalized sum-capacity for many classes of deterministic and Gaussian interference networks. In many cases, a scheduling scheme called maximal independent graph scheduling is shown to achieve normalized sum-capacity. We also show that its generalization for 1-local view, labeled coded set scheduling, achieves normalized sum-capacity in some cases where its uncoded counterpart fails to do so.
GaN MEMS resonators : from demonstration to microsystem-compatible performances (2012)

International audience
WOMEN’S SEXUAL HEALTH FROM A CULTURAL VIEWPOINT (2013)

Objective: Get to know the topics approached in national publications on women's sexual health and identify the cultural and social aspects envisaged. Method: Descriptive-analytical bibliographic review made in the Virtual Health Library database, using the following criteria: national publications from 2000 to 2011, full texts involving the female population. Twelve publications were analyzed through an integrative literature review. Results: The interface between women's sexual health and the cultural aspects is reflected on the behavior, attitudes and lifestyles. The vulnerability to which women are exposed originate from several natures, represent several cultures and, sometimes, are crystallized by ongoing Sexually Transmitted Diseases, unwanted pregnancy and violence. Conclusion: By updating the knowledge on factors that interfere on the care of women's sexual health, it is evident that a less technical and more emancipatory sexual health care approach is urgent.
A THIOPHENE ISOSTER OF CHLORAMPHENICOL IN THE ERYTHRO SERIES<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA THIOPHENE ISOSTER OF CHLORAMPHENICOL IN THE ERYTHRO SERIES1CHARLES F. HUEBNER, P. A. DIASSI, and CAESAR R. SCHOLZCite this: J. Org. Chem. 1953, 18, 1, 21–29Publication Date (Print):January 1, 1953Publication History Published online1 May 2002Published inissue 1 January 1953https://pubs.acs.org/doi/10.1021/jo01129a005https://doi.org/10.1021/jo01129a005research-articleACS PublicationsRequest reuse permissionsArticle Views247Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibitors of Arterial Relaxation Among Components of Human Oxidized Low-Density Lipoproteins (1997)

Cholesterol derivatives in oxidized LDL can reduce maximal arterial relaxation through a specific effect on vascular endothelial cells.