gebhart/patrepeval huggingface dataset:
Changes in plasma lipaemia, glycaemia and uremia caused by the negative interaction of the genotype and environment during the laying period of hens of initial lines of laying hybrids* (2000)

Abstract. During the laying period the changes in concentrations of plasma total lipids, cholesterol, glucose and urea were studied in the RIW laying line selected for the number of eggs laid during the eight month laying period. The feed mixtures were changed qualitatively causing both changes in plasma lipaemia, glycaemia and uremia and time-limited reduction in the body weight and laying intensity. Average concentrations of the individual blood indicators of the entire group of hens during the laying period ranged as follows: total lipids 5.06 ± 0.63 g.l−1 to 21.51 ± 5.28 g.l−1, cholesterol 1.99 ± 0.45 mmol. l−1 to 4.73 ± 1.54 mmol. l−1, glucose 4.43 ± 0.51 mmol .l−1 to 19.02 ± 5.25 mmol.l−1 and urea 3.53 ± 0.98 mmol.l−1 to 6.29 ± 2.51mmol.l−1. The concentrations of the given biochemical indicators were also studied to contrast at the age of 25 weeks in other lines of hens originating from the RIW and BPR lines. The average values of all the studied indicators were different in lines of different laying intensity and earliness (fed the same feed mixture in the same hall), i.e. total lipids 25.00 ±7.51 to 45.85 ± 11.98 g.l−1, cholesterol 3.25 ± 0.85 to 4.83 ± 0.81 mmol.l−1, glucose 11.91 ±2.69 to 15.15 ± 1.98 mmol.−1 and urea 3.08 ± 0.53 to 6.90 ± 1.61 mmol.l−1. We can say that during the laying period important changes in plasma lipaemia, glycaemia and uremia of the hens occur in dependence on changes in the feed mixture or in its quality too. These criteria monitor the level of interaction between the genotype and the environment on the level of pre-clinical response of the organism.
Carotene Retention in Alfalfa Meal. Effect of Moisture Content (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarotene Retention in Alfalfa Meal. Effect of Moisture ContentG. F. Bailey, M. E. Atkins, and E. M. BickoffCite this: Ind. Eng. Chem. 1949, 41, 9, 2033–2036Publication Date (Print):September 1, 1949Publication History Published online1 May 2002Published inissue 1 September 1949https://pubs.acs.org/doi/10.1021/ie50477a048https://doi.org/10.1021/ie50477a048research-articleACS PublicationsRequest reuse permissionsArticle Views17Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Flow Microreactor System Enables Organolithium Reactions without Protecting Alkoxycarbonyl Groups (2010)

A flow microreactor system consisting of micromixers and microtube reactors provides an effective tool for the generation and reactions of aryllithiums bearing an alkoxycarbonyl group at para-, meta-, and ortho-positions. Alkyl p- and m-lithiobenzoates were generated by the I/Li exchange reaction with PhLi. The Br/Li exchange reactions with sBuLi were unsuccessful. Subsequent reactions of the resulting aryllithiums with electrophiles gave the desired products in good yields. On the other hand, alkyl o-lithiobenzoates were successfully generated by the Br/Li exchange reaction with sBuLi. Subsequent reactions with electrophiles gave the desired products in good yields.
Comprehensive genetic characterization of TFE3-positive renal cell carcinoma. (2018)

635 Background: MiT family translocation renal cell carcinoma (RCC) is very rare variant which has translocation of Xp11.2/TFE3 gene or t(6;11)/TFEB gene. Xp11.2 translocation RCC is predominantly reported in younger age and has aggressive features. However, its pathophysiology or genetic characteristics are rarely understood. The aim of the study is to describe the comprehensive genetic characteristics of TFE3-positive RCC diagnosed by immunohistochemistry. Methods: We identified patients who were clinically diagnosed as Xp11.2 translocation RCC by immunostaining positive of TFE3 from two tertiary referral hospitals. Among them, a total of 19 patients whose fresh frozen tissue and normal DNA were achieved were included in the analysis. Whole exome sequencing (WES) was performed to evaluate somatic mutations and copy-number variation (CNV). We also performed RNAseq on the TFE3-positive RCC, 7 clear cell RCC, and 4 normal kidney tissue for comparison. Fusion partners were identified and clustering analysis was done by RNAseq. Results: Mutational landscape of TFE3-positive RCC is unique by low somatic mutation rate and very rare COSMIC variants. High prevalence of CNV with loss of 3p, 6q, 9, gain of 5, 7, and 12 were most frequent. We identified NONO, RBM10, SFPQ, ASPSCR1 and PRCC as fusion partner as previously described. We could not find TFE3 fusion in 6 out of 19 patients by RNAseq, and they were older and had more mutations than the others. They were also genetically clustered with clear cell RCC. Oxidative reducatase pathway was upregulated and immune response and cell adhesion were downregulated by gene ontology results from heatmap clusters. These may promote metastasis, resistant to immunity and cell survival in poorer condition which could be potential mechanism of Xp11.2 translocation RCC aggressiveness. Conclusions: TFE3-positive RCC showed distinctive mutation pattern with low somatic mutation and rare common driver gene. One-third clinically diagnosed Xp11.2 translocation RCC (6/19) did not have real gene fusion even in TFE3 overexpression. They were older and had more somatic mutations than the others. Furthermore, they were clustered with clear cell RCC.
Inferring strategies from limited reconnaissance in real-time strategy games (2012)

In typical real-time strategy (RTS) games, enemy units are visible only when they are within sight range of a friendly unit. Knowledge of an opponent’s disposition is limited to what can be observed through scouting. Information is costly, since units dedicated to scouting are unavailable for other purposes, and the enemy will resist scouting attempts. It is important to infer as much as possible about the opponent’s current and future strategy from the available observations. We present a dynamic Bayes net model of strategies in the RTS game Starcraft that combines a generative model of how strategies relate to observable quantities with a principled framework for incorporating evidence gained via scouting. We demonstrate the model’s ability to infer unobserved aspects of the game from realistic observations. 1
Nanometrological micromachined artefacts (1992)

The fabrication of some unique artefacts with critical dimensions from deep submicron to several microns is described. These have been fabricated in silicon, in phosphosilicate glass (PSG) and in polysilicon films. The thermal reflow properties of PSG have been used to obtain artefacts with smooth spherical and cylindrical surfaces and the phosphorus concentration dependent etch rate of PSG in an HF:HNO3:CH3COOH etch has been used to create a periodic structure with a pitch of about 100 nm. Thermal plastic deformation of silicon has been utilised to fabricate a variety of shapes with a range of surface features. Plasma etching and wet chemical etching of silicon have produced gratings with well defined edges and periodicity. Initial results indicate that these are ideally suited for use as specimen standards in profilometry and in particular in atomic force microscopy.
Lipid Biomarker Patterns of Phosphogenic Sediments from Upwelling Regions (2008)

Sediments of upwelling regions off Namibia, Peru, and Chile contain dense populations of large nitrate-storing sulfide-oxidizing bacteria, Thiomargarita, Beggiatoa, and Thioploca. Increased contents of monounsaturated C16 and C18 fatty acids have been found at all stations studied, especially when a high density of sulfide oxidizers in the sediments was observed. The distribution of lipid biomarkers attributed to sulfate reducers (10MeC16:0 fatty acid, ai-C15:0 fatty acid, and mono-O-alkyl glycerol ethers) compared to the distribution of sulfide oxidizers indicate a close association between these bacteria. As a consequence, the distributions of sulfate reducers in sediments of Namibia, Peru, and Chile are closely related to differences in the motility of the various sulfide oxidizers at the three study sites. Depth profiles of mono-O-alkyl glycerol ethers have been found to correlate best with the occurrence of large sulfide-oxidizing bacteria. This suggests a particularly close link between mono-O-alkyl glycerol ether-synthesizing sulfate reducers and sulfide oxidizers. The interaction between sulfide-oxidizing bacteria and sulfate-reducing bacteria reveals intense sulfur cycling and degradation of organic matter in different sediment depths.
A Simulated Annealing-Based Approach to Three-Dimensional Component Packing (1995)

This paper introduces a simulated annealing-based approach to three-dimensional component packing that employs simulated annealing to generate optimal solutions. Simulated annealing has been used extensively for two-dimensional layout of VLSI circuits; this research extends techniques developed for two-dimensional layout optimization to three-dimensional problems which are more representative of mechanical engineering applications. This research also provides a framework in which to solve general component layout problems.
Cooperation between two <i>Thiobacillus</i> strains for heavy-metal removal from municipal sludge (1992)

A mixed culture of two fast-growing bacterial strains for heavy-metal solubilization of municipal sewage sludge has been developed. Strain VA-7 decreases the initial sludge pH (7-8.5) to a value between 4.0 and 4.5. Then, strain VA-4 begins growing and further reduces the pH to values below 2.0. The rapid decrease of sludge pH by a mixed culture through sulfur oxidation into sulfuric acid solubilizes the toxic metals (Cd 83-96%, Cr 16-54%, Cu 85-87%, Mn 91-94%, Ni 78-79%, Pb 28-46%, Zn 82-96%) to levels recommended for intensive use of residual sludge in agriculture. A study of the physiological and metabolic characteristics of these strains revealed that isolate VA-7 is a strain of Thiobacillus thioparus (ATCC 55127), while isolate VA-4 corresponds to a Thiobacillus thiooxidans (ATCC 55128). These bacterial strains possess distinctive physiological characteristics that allow them to easily grow and solubilize heavy metals in municipal sludge.
[Cruciate ligament prostheses. Techniques, results and perspectives]. (1993)

Artificial ligaments have been used as augmentation devices, scaffolds, ingrowth ligaments and even prostheses. The augmentation devices rely entirely on the autologous tissue for their function, whereas each of the other types functions more or less as a prosthesis. These devices can function only for a limited time and they are very sensitive to the implantation technique. Problems involve debris formation, synovitis and finally ligament rupture. There is also a loss of stability in the treated knee over the first 2-3 postoperative years. The clinical results obtained in various studies with the prosthetic devices are not satisfactory. The problem of reconstruction of a knee with ligamentous instability is far greater than that involved in replacing the ligament only.
Thermodynamic analysis of substituent effects on proton dissociation equilibria of substituted pyridines (1973)

Equilibrium constants for the dissociation of RC5H4NH+(R = 3- and 4-Br, 3- and 4-CN, and 2- and 3-NH2) have been measured as a function of temperature in the range 5–65 °C. For these and other literature data (R = H, 2-, 3-, and 4-NO2, 2-, 3-, and 4-Me, 2-, 3-, and 4-CHO, 2-, 3-, and 4-Ac, 2-CH2NHMEe, and 4-NH2) thermodynamic functions (ΔG0, ΔH0, and ΔS0) have been calculated by a thermodynamic optimization method and by the Clarke and Glew procedure. Substituent effects, the environmental parameter for the reaction series examined, and solvent–solute interactions are discussed on the basis of Hepler's dichotomized enthalpy–entropy model, and the approach developed by Bolton et al.
A simple method to perform a liquid diffusion crystallization (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simple method to perform a liquid diffusion crystallizationChris Orvig Cite this: J. Chem. Educ. 1985, 62, 1, 84Publication Date (Print):January 1, 1985Publication History Received3 August 2009Published online1 January 1985Published inissue 1 January 1985https://doi.org/10.1021/ed062p84RIGHTS & PERMISSIONSArticle Views1574Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (385 KB) Get e-Alerts Get e-Alerts
Highly Parallelizable Problems (Extended Abstract) (1989)

The ongoing activity of the human retrotransposon Long Interspersed Element 1 (LINE-1 or L1) continues to impact the human genome in various ways. Throughout evolution, mammalian and primate genomes have been under selection to generate strategies to reduce the activity of selfish DNA like L1. Similarly, selfish DNA has evolved to elude these containment systems. This intragenomic conflict has left many inactive versions of LINEs and other Transposable Elements (TEs) littering the human genome, which together account for roughly half of our DNA. Here, we survey the distinct mechanisms operating in the human genome that seem to reduce the mobility of L1s. In addition, we discuss recent findings that strongly suggest epigenetic mechanisms specifically regulate L1 activity in pluripotent human cells.
Immunoglobulin x light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement (1989)

We have produced transgenic mice which synthesize chimeric mouse-rabbit immunoglobulin (Ig) kappa light chains following in vivo recombination of an injected unrearranged kappa gene. The exogenous gene construct contained a mouse germ-line kappa variable (V kappa) gene segment, the mouse germ-line joining (J kappa) locus including the enhancer, and the rabbit b9 constant (C kappa) region. A high level of V-J recombination of the kappa transgene was observed in spleen of the transgenic mice. Surprisingly, a particularly high degree of variability in the exact site of recombination and the presence of non germ-line encoded nucleotides (N-regions) were found at the V-J junction of the rearranged kappa transgene. Furthermore, unlike endogenous kappa genes, rearrangement of the exogenous gene occurred in T-cells of the transgenic mice. These results show that additional sequences, other than the heptamer-nonamer signal sequences and the promoter and enhancer elements, are required to obtain stage- and lineage- specific regulation of Ig kappa light chain gene rearrangement in vivo.
You Will Eat Rock (2002)

The author presents his photographs taken in East Timor during November and December 1999, following violence after the people of East Timor voted in favour of independence on August 30, 1999. He states that burnt buildings with the words 'If you want freedom, you will eat rock' written on their walls bore testimony to the atrocities committed.
Explicit Modeling of Crack Initiation and Propagation in the Microstructure of a Ceramic Material Generated with Voronoi Tessellation (2013)

This chapter contains sections titled: Introduction Generation of Polycrystals Modelling of the Polycrystalline Microstructure Evaluation of the Macroscopic Elastic Constants Simulation of the Failure of a Micro-Cantilever Beam Conclusions Acknowledgements
GENO-37MOLECULAR PROFILING OF LONG-TERM SURVIVORS OF GLIOBLASTOMA (2015)

Few patients with glioblastoma survive beyond 5 years. In this project, the molecular features associated with these exceptional long term survivors (LTS) were evaluated. Patients diagnosed with glioblastoma within the past 30 years surviving >= 5 years were identified from the Mayo tumor registry. Of 1176 patients with glioblastoma in the registry, 40 were LTS (median age 50.4 years; median survival 7.8 years). Pathology was reviewed and diagnosis confirmed by a certified neuropathologist (CG). Histology was fibrillary in 30 (75%) patients. Most (23, 58%) tumors were located in the frontal lobes. Gross total resection was achieved in 26 (65%). Adjuvant radiotherapy was delivered in 35 ( >= 60 Gy in 31). Temozolomide was given in 20 (50%) and BCNU in 12 (30%). In the 22 patients with tissue available for analysis (median age 49.2 years; median survival 7.0 years), TCGA molecular subtype breakdown from RNA extracts analyzed by Nanostring was: proneural 11, neural 0, classical 6, mesenchymal 2, and unknown 3 (insufficient RNA). Next-generation sequencing revealed the following mutations: 12 TERT, 12 ATRX, 12 TP53, 10 IDH, 8 PIK3CA/PIK3R1, 8 PTEN, 4 RB1, and 3 EGFR. 1p19q codeletion (determined via OncoScan assay), TERT, and IDH mutations were used to stratify patients into risk categories: 9 TERT-mutation only, 8 IDH-mutation only, 2 triple positive, and 3 triple negative. The frequency of IDH mutation in LTS (8/22) was significantly higher than observed in a contemporaneous cohort of short-surviving glioblastoma (32/470, p < 0.0001). All IDH mutations were in TCGA proneural patients. Long-term glioblastoma survival is enriched for patients with IDH-mutation only gliomas, although approximately half of tumors have molecular features associated with a more typical aggressive clinical course. Future studies are focused on understanding the mechanisms associated with prolonged survival in the TERT-mutation only tumors.
Chemical genetics to identify NFAT inhibitors: Potential of targeting calcium mobilization in immunosuppression (2004)

The development of more selective immunosuppressive agents to mitigate transplant rejection and autoimmune diseases requires effective strategies of blocking signaling pathways in T cells. Current immunosuppressive strategies use cyclosporin A (CsA) or FK506 to inhibit calcineurin, which dephosphorylates and promotes the nuclear import of nuclear factor of activated T cells (NFAT) transcription factors. These nuclear NFATs then transactivate cytokine genes that regulate proliferative responses of T cells. Both CsA and FK506 have debilitating side effects, including nephrotoxicity, hypertension, diabetes, and seizures, that argue for the development of alternative or complementary agents. To this end, we developed cell-based assays for monitoring NFAT dynamics in nonlymphoid cells to identify small molecules that inhibit NFAT nuclear import. Interestingly, we found that the majority of these small molecules suppress NFAT signaling by interfering with "capacitative" or "store-operated" calcium mobilization, thus raising the possibility that such mobilization processes are relevant targets in immunosuppression therapy. Further, these small molecules also show dose-dependent suppression of cytokine gene expression in T cells. Significantly, the IC(50) of CsA in primary T cells was reduced by the addition of suboptimal concentrations of these compounds, suggesting the possibility that such small molecules, in combination with CsA, offer safer means of immunosuppression.
Surgery in patients with von Willebrand's disease (1989)

The risk of bleeding complications in the surgical treatment of patients with von Willebrand's disease has been evaluated. Sixty-four major surgical procedures were performed in 51 patients with various forms of von Willebrand's disease. In 18 cases, the bleeding disorder was unknown at the time of surgery, resulting in bleeding complications in 12 cases (67 per cent). Forty-five operations were carried out in patients in whom the diagnosis of von Willebrand's disease was known at the time of surgery. In these patients, the following haemostatic preparations were given: factor concentrate, fresh plasma, tranexamic acid and desmopressin. Haemostatic complications occurred in three of these operations (6.7 per cent); all were managed easily. No mortality was observed. It is concluded that patients with von Willebrand's disease do not carry an increased operative risk if appropriate precautions are taken.
Thinned Backside Illuminated CCDs For Ultraviolet Imaging (1988)

This paper presents the first results obtained at Thomson-CSF on thinned CCDs (576 x 384 pixels) developed for ultraviolet imaging. The process involves chemical thinning of the CCD down to about 10 microns, followed by a shallow implantation (p<sup>+</sup> for backside accumulation) activated by laser annealing. UV quantum efficiencies as high as 20 % are measured at 2540 A despite an absorption length in silicon of 55 A at this wavelength. Measurements under 5.9 keV (Fe<sup>55</sup>) X-ray irradiation have shown 295 eV FWHM energy resolution. After optimization of various parameters in the backside treatment, this technology will in course be applied to several sensors : 1024 x 1024 and buttable devices.
Catalytic multi-stage liquefaction of coal twelth quarterly report for the period 1 July 1995--30 September 1995 (1995)

The overall objective of this program is to produce liquid fuels from coal by direct liquefaction at a cost that is competitive with conventional fuels. Specifically, this continuous bench-scale program contains provisions to examine new ideas in areas such as: low temperature pretreatments, more effective catalysts, on-line hydrotreating, new coal feedstocks, other hydrogen sources, more concentrated coal feeds and other highly responsive process improvements while assessing the design and economics of the bench- scale results. This quarterly report covers work on Laboratory Scale Studies, Continuous Bench-Scale Operations, Technical Assessment and Project Management.