gebhart/patrepeval huggingface dataset:
Antifeedant Activity of Limonin Against the Colorado Potato Beetle (Coleoptera: Chrysomelidae) (1987)

The antifeedant activity of limonin against fourth-instar Colorado potato beetles, Leptinotarsa decemlineata (Say), was evaluated in choice and no-choice laboratory feeding assays with coated potato leaf disks. Foliage consumption was reduced 19.5, 64.4, and 67.4%, respectively, by limonin dosages of 10, 31.7, and 100 μg/cm2 in the choice tests. Consumption reduction of 64.6, 89.5, and 96.0%, respectively, with the same dosages in the no-choice tests, demonstrated increased sensitivity of the latter test condition. Conversions of the amount of foliage consumed to amount of limonin ingested indicated that greater antifeedant activity in the no-choice situation was directly related to increased limonin ingestion.
Spatial Distribution of Milk Constituents in Powders Made by Different Drying Techniques (1964)

Layers of milk solids were washed from the surfaces of five different types of powder granules by using a vacuum to draw successive 50-ml aliquots of water rapidly through a bed containing a mixture of 5 g of milk .powder and 60 g of 20-30 mesh sand.
Cyanide-Bridged Lanthanide−Transition Metal One-Dimensional Arrays {(DMF)<sub>10</sub>Yb<sub>2</sub>[Ni(CN)<sub>4</sub>]<sub>3</sub>}<sub>∞</sub> and {(DMF)<sub>10</sub>Yb<sub>2</sub>[Pt(CN)<sub>4</sub>]<sub>3</sub>}<sub>∞</sub> (1996)

The one-dimensional arrays {(DMF)10Yb2[Ni(CN)4]3}∞ (1) and {(DMF)10Yb2[Pt(CN)4]3}∞ (2) were prepared from the metathesis reactions of YbCl3 and K2Ni(CN)4 or K2Pt(CN)4 in DMF (DMF = N,N-dimethylformamide). Unlike other one-dimensional structures adopted by complexes of M(CN)42- anions, two unusual array structures were obtained.
Endourologic Control of Incontinence with GAX Collagen: The LSU Experience (1992)

Extensive experience has been documented in the use of transcystoscopic injectables in a wide variety of urologic situations. Incontinence has been the primary indication for the use of these substances, and clinical trials have met with success. Concern about particle migration has raised doubts about long-term human safety with some substances such as Teflon. Glutaraldehyde cross-linked (GAX) collagen (Contigen; Bard) has been used in several clinical trials. At our institution, more than 100 patients have been treated to date for incontinence, primarily postprostatectomy in men and Type III stress incontinence in women as part of a larger multicenter trial currently being concluded. This substance has demonstrated ease of use, adaptability to office technique under local anesthesia, and high rates of success.
<p>Sirt6-Mediated Endothelial-to-Mesenchymal Transition Contributes Toward Diabetic Cardiomyopathy via the Notch1 Signaling Pathway</p> (2020)

This study is the first to demonstrate that Sirt6 participates in EndMT via the Notch1 signaling pathway in CMECs stimulated with HG+PA. Therefore, the findings of this study suggest that Sirt6 could provide a potential treatment strategy for DCM.
Accumulation of unintegrated circular viral DNA in monocytes and growth-arrested T cells following infection with HIV-1 (1994)

Cytocidal retrovirus infection is characterized by rapid accumulation of unintegrated viral DNA forms. These are thought to be generated by multiple rounds of reinfection and have been suggested to play a central role in cytopathogenesis. Here we have reviewed the work done in this area with HIV-1, mostly using acutely and chronically infected T cell and monocytic cell lines and in some cases T cells blocked at S phase of the cell cycle by aphidicolin treatment. To these studies, we have compared our findings with HIV-1 infected primary peripheral blood monocyte-derived macrophages and untreated and growth-arrested MT-2 cells, two biologically disparate cell populations. Using 1- and 2-long terminal repeat (LTR) circular forms as indicators of unintegrated viral DNA, we found similar rapid accumulation in both untreated and growth-arrested MT-2 cells. In contrast, we found much lower levels in monocyte/macrophages. Our findings suggest that accumulation of unintegrated viral DNA does not require virus production and reinfection in growth-arrested T cells. The significantly lower levels found in monocyte/macrophages may reflect superinfection resistance, allowing the maintenance of a persistent infection.
Phase II trial of docetaxel in advanced or metastatic endometrial cancer: a Japanese Cooperative Study (2005)

The purpose of this study was to determine whether docetaxel has antitumour activity in patients with advanced or recurrent endometrial carcinoma. Chemotherapy-naïve or previously treated patients (one regimen) with histopathologically documented endometrial carcinoma and Eastern Cooperative Oncology Group performance status </=2 entered the study. Docetaxel 70 mg m(-2) was administered intravenously on day 1 of a 3-week cycle up to a maximum of six cycles. If patients responded well to docetaxel, additional cycles were administered until progressive disease or unacceptable toxicity occurred. Of 33 patients with a median age of 59 years (range, 39-74 years) who entered the study, 14 patients (42%) had received one prior chemotherapy regimen. In all, 32 patients were evaluable for efficacy, yielding an overall response rate of 31% (95% confidence interval, 16.1-50.0%); complete response and partial response (PR) were 3 and 28%, respectively. Of 13 pretreated patients, three (23%) had a PR. The median duration of response was 1.8 months. The median time to progression was 3.9 months. The predominant toxicity was grade 3-4 neutropenia, occurring in 94% of the patients, although febrile neutropenia arose in 9% of the patients. Oedema was mild and infrequent. Docetaxel has antitumour activity in patients with advanced or recurrent endometrial carcinoma, including those previously treated with chemotherapy; however, the effect was transient and accompanied by pronounced neutropenia in most patients.
Nanoreactors: An Efficient Tool To Control the Chain-Length Distribution in Fischer–Tropsch Synthesis (2016)

One of the main problems of the Fischer–Tropsch synthesis is the overly broad distribution of the produced hydrocarbons due to the Anderson–Schulz–Flory law. This work is directed toward the solution of this problem by the application of nanoreactors with incorporated metal nanoparticles. Our results show that encapsulation of Co nanoparticles in nanosized porous silica spheres results in higher activity per catalyst weight and stability with a shift of the chain length distribution of hydrocarbons to lower values in comparison with Fischer–Tropsch synthesis over impregnated catalysts. These effects are due to the presence of well-dispersed isolated and stable Co nanoparticles inside of nanoreactors and shape selectivity effects which restrict the chain growth by the walls of nanoreactors. The proposed new strategy can be further extended to synthesis of olefins and alcohols with desired chain-length distribution from syngas by encapsulation of other metals (Fe, Cu, Rh, etc.).
A study of HCI for people in Japan with communication disorders. (2001)

A variety of molecules are involved in the interaction of human allospecific cytolytic T lymphocytes (CTL) with target cells. Monoclonal antibodies specific for these molecules inhibit CTL-target conjugate formation and/or lysis. To further study recognition and lysis of targets by human CTL, we used a murine mastocytoma cell line transfected with the histocompatibility leukocyte antigen (HLA)-A2 gene (P815-A2+) as a target for human HLA-A2-specific CTL. We find that only a subset of human HLA-A2-specific CTL can lyse murine P815-A2+ cells, suggesting that the murine cells may lack one or more accessory molecules needed for CTL recognition and lysis.
Neuropeptides: Mediators of Behavior in <i>Aplysia</i> (1984)

The Aplysia neuroendocrine system is a particularly advantageous model for cellular and molecular studies because of the relatively small number and large size of its component neurons. Recombinant DNA techniques have been used to isolate the genes that encode the precursors of peptides expressed in identified neurons of known function. The organization and developmental expression of these genes have been examined in detail. Several of the genes encode precursors of multiple biologically active peptides that are expressed in cells which also contain classical transmitters. These studies, as well as immunohistochemical studies and the use of intracellular recording and voltage clamp techniques are the first steps toward revealing the mechanisms by which neuropeptides govern simple behaviors.
Space-time adaptive processing and subband array implementations (2003)

Inter-symbol interference (ISI) and co-channel interference (CCI) are two major sources to signal impairment in mobile communications. To suppress both ISI and CCI, space-time adaptive processing (STAP) systems are shown to be effective, leading to increased capacity and improved quality of service. The high complexity and slow convergence, however, are often the hurdles in practical implementation of the STAP systems. Several subband array implementations have been proposed for STAP over the past few years. These methods are to provide optimal or sub-optimal steady state performance with reduced implementation complexity and improved convergence performance. The purpose of this paper is to investigate the steady state performance of subband arrays with different decimation rates and to derive analytical expressions of the minimum mean square error (MMSE). The discrete Fourier transform (DFT) based subband arrays and both unconstrained and constrained weight adaptations are considered.
Reproducibility of Metabolomic Profiles among Men and Women in 2 Large Cohort Studies (2013)

For potential use in epidemiologic studies, the majority of plasma metabolites had low CVs and were reproducible over a 24-h processing delay and within individuals over 1-2 years. Certain metabolites, such as carbohydrates and purine/pyrimidine derivatives, may be challenging to evaluate if samples have delayed processing.
Why mother rats protect their children (2017)

The presence of the hormone oxytocin in the central amygdala makes a mother rat willing to put her life in danger in order to protect her offspring.
Simultaneous Suppression of π- and σ-Transmission in π-Conjugated Molecules (2020)

Molecular dielectric materials require ostensibly conflicting requirements of high polarizability and low conductivity. As previous efforts toward molecular insulators focused on saturated molecules, it remains an open question whether π- and σ-transport can be simultaneously suppressed in conjugated systems. Here, we demonstrate that there are conjugated molecules where the σ-transmission is suppressed by destructive σ-interference, while the π-transmission can be suppressed by a localized disruption of conjugation. Using density functional theory, we study the Landauer transmission and ballistic current density, which allow us to determine how the transmission is affected by various structural changes in the molecule. We find that in para-linked oligophenyl rings the σ-transmission can be suppressed by changing the remaining hydrogens to methyl groups due to the inherent <i>gauche</i>-like structure of the carbon backbone within a benzene ring, similar to what was previously seen in saturated systems. At the same time, the methyl groups fulfill a dual purpose as they modulate the twist angle between neighboring phenyl rings. When neighboring rings are orthogonal to each other, the transmission through both π- and σ-systems is effectively suppressed. Alternatively, breaking conjugation in a single phenyl ring by saturating two carbons atoms with two methyl substituents on each carbon, results in suppressed π- and σ-transport independent of dihedral angle. These two strategies demonstrate that methyl-substituted oligophenyls are promising candidates for the development of molecular dielectric materials.
Nanocrystalline Twinning Induced Plasticity Steel with Superior Mechanical Properties Fabricated by Cold Rolling and Annealing (2013)

A study has been carried out on the evolution of microstructure, grain boundary character and mechanical properties in a Twinning Induced Plasticity steel heavily cold rolled and subsequently annealed.The cold rolled mcrostructures showed fine lamellar boundaries with many shear bands.With progress of annealing, numerous numbers of recrystallized grains were generated.The fully recrystallized steel showed equi-axed nanocrystalline grains with a mean grain size of 400 nm that enhanced the yield strength significantly while retaining tensile ductility.
Diferentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation # (2009)

These studies demonstrate a previously unrecognized role of ACs in biliary pathophysiology. In fact: (1) AC isoforms are differentially expressed in cholangiocyte subpopulations; (2) AC8, AC9, and sAC mediate cholangiocyte secretion in response to secretin, beta-adrenergic agonists, or changes in [HCO(3)(-)](i), respectively; and (3) AC gene expression is modulated in experimental cholestasis.
Gas Chromatography Analysis of Diphenyl-Diacetylene Liquid Crystals (1995)

Abstract A gas chromatography method is used to investigate the purity of dialkyl-diphenyl-diacetylene liquid crystal components and at the same time identify the structure and concentration of the major impurities.
A New Method for the Synthesis of α-Substituted Phenethylamines via Titanium Amide Complexes (1988)

Substituted phenethylamines (1-substituted 2-phenylethylamines) 4 are obtained in high yields by a new, facile reaction of titanium amide complexes with aldehydes and benzylmagnesium chloride.
Electrosynthesis of Unique Ag<sup>II</sup> Fluoride Quantum Antiferromagnets in Anhydrous HF (2020)

The first successful electrosynthesis of polycrystalline Ag II FBF 4 and single crystalline Ag II F 2 in both galvanostatic and potentiostatic conditions was achieved at the Boron‐Doped Diamond electrode in anhydrous hydrogen fluoride. Silver(I) oxidation and the F 2 evolution reactions are well separated in the potential scale. Temperature of performing electrosynthesis as well as BF 3 overpressure were found to be key variables of the process. Impedance spectroscopy measurements provided insight into the mechanism of formation of silver(II) fluorides pointing out to the presence of HF‐soluble Ag(BF 4 ) 2 intermediate. The phase purity of the products was determined by X‐ray diffraction.
Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes. (1996)

The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2, and the RPM1 resistance gene is involved in recognition of pathogens carrying avrRpm1 or avrB. We identified and cloned two Arabidopsis genes, AIG1 and AIG2 (for avrRpt2-induced gene), that exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. However, ES4326 carrying avrRpm1 or avrB did not induce early expression of AIG1 and AIG2. Conversely, ES4326 carrying avrRpm1 or avrB induced early expression of the previously isolated defense-related gene ELI3, whereas ES4326 carrying avrRpt2 did not. The induction patterns of the AIG genes and ELI3 demonstrate that different resistance gene-avr gene combinations can elicit distinct defense responses. Furthermore, by examining the expression of AIG1 and ELI3 in plants infiltrated with a mixed inoculum of ES4326 carrying avrRpt2 and ES4326 carrying avrRpm1, we found that there is interference between the RPS2- and RPM1-mediated resistance responses.
ChemInform Abstract: Nucleic Acid Related Compounds. Part 93. A Solution for the Historic Problem of Regioselective Sugar‐Base Coupling to Produce 9‐ Glycosylguanines or 7‐Glycosylguanines. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Width minimization of two-dimensional CMOS cells using integer programming (2002)

We address the problem of CMOS cell width minimization in the general two-dimensional (2-D) layout style and propose a novel technique based on integer linear programming (ILP) to solve it exactly. We formulate a 0-1 ILP model whose solution minimizes cell width along with the routing complexity across the diffusion rows. We present experimental results that evaluate the performance of two ILP solvers that have very different solution methods, and assess the effect of the number of rows on cell width. Runtimes for optimal layouts are in seconds for cells with up to 20 transistors. For larger cells, we propose a practical circuit pre-processing scheme that dramatically reduces the run time with little or no loss in optimality.
APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa (2008)

The bone marrow constitutes a favorable environment for long-lived antibody-secreting plasma cells, providing blood-circulating antibody. Plasma cells are also present in mucosa-associated lymphoid tissue (MALT) to mediate local frontline immunity, but how plasma cell survival there is regulated is not known. Here we report that a proliferation-inducing ligand (APRIL) promoted survival of human upper and lower MALT plasma cells by upregulating expression of the antiapoptotic proteins bcl-2, bcl-xL, and mcl-1. The in situ localization of APRIL was consistent with such a prosurvival role in MALT. In upper MALT, tonsillar epithelium produced APRIL. Upon infection, APRIL production increased considerably when APRIL-secreting neutrophils recruited from the blood infiltrated the crypt epithelium. Heparan sulfate proteoglycans (HSPGs) retained secreted APRIL in the subepithelium of the infected zone to create APRIL-rich niches, wherein IgG-producing plasma cells accumulated. In lower MALT, neutrophils were the unique source of APRIL, giving rise to similar niches for IgA-producing plasmocytes in villi of lamina propria. Furthermore, we found that mucosal humoral immunity in APRIL-deficient mice is less persistent than in WT mice. Hence, production of APRIL by inflammation-recruited neutrophils may create plasma cell niches in MALT to sustain a local antibody production.
A computer and experimental simulation of Stirling cycle machines (1978)

The computer simulation of Stirling cycle machines developed by Urieli is evaluated against experimental results and ideal analyses. The experimental results were obtained from a rig which was designed to simulate the thermodynamic conditions present in real machines. For this particular rig the simulation consistently underpredicts the overall heat energy reguirements by approximately 13%. The ideal analyses used in the comparison are the Schmidt analysis and a form of second order ideal pseudo-Stirling analysis (Finkelstein's adiabatic analysis.) The complete mathematical derivations of the relevant equations are not reported, these are available in the references cited. /SAE/
[Insulin catabolism by transformed, cultivated mouse fibroblasts (L-cells)]. (1976)

Cultivated, transformed mouse fibroblasts (L-cells) are endowed with enzyme systems for insulin breakdown that are comparable to those of many other types of non-dedifferentiated insulin target cells (time and substrate dependence, Km value). It cannot yet be decided, however, which of the potential enzyme systems (thiolproteindisulfide-oxidoreductase (TPO) [E.C. 1.8.4.2] or proteinase) is prevalent in insulin breakdown in intact L-cells. Despite the lack of typical target symptoms for insulin, the cultivated L-cell could provide an appropriate experimental model for the insulin metabolism.
Practice patterns for achalasia - room for improvement? authors’ reply (2011)

Sirs, We appreciate the thoughtful comments by Dr Leeuwenburgh et al.1 The diagnosis of achalasia in the cases from our database study was based upon the endoscopist’s suspicion for the disease, as well as additional clinical information, which may have included barium studies and oesophageal manometry.2 The diagnosis was not made solely by endoscopy, but because of the nature of the CORI database, our analysis focused primarily on the available data associated with the endoscopic procedures. Given the nature of the database, we also had little or no information whether other treatment modalities were used in 40% of our case population, which may have included Heller myotomy in large fraction of patients. We concur that the majority of treatments employed in this study were suboptimal in providing a durable response to symptoms of patients with achalasia. As an unexpected observation of our study, many physicians were found to utilise management options that deviate from the published guidelines. We speculate that temporising measures such as Savary or Maloney dilation or even Botox injection were chosen because endoscopists feared the risks associated with pneumatic dilation, despite the low rates of complications cited in the literature. These practice patterns may also reflect on changing patterns in diagnosing achalasia, as many physicians probably use the response to empiric dilation or Botox injection to guide them in confirming or refuting the diagnosis. In contrast with the data cited by Dr Leeuwenburgh et al., which were generated by tertiary referral centres dedicated to the management of achalasia, our study reports on practice patterns in the general community of gastroenterologists. Declaration of personal and funding interests: None.
Studies on the folding and unfolding of glycerol dehydrogenase from <i>Bacillus stearothermophilus</i> (1998)

Conference Article| August 01 1998 Studies on the folding and unfolding of glycerol dehydrogenase from Bacillus stearothermophilus Oliver Krauss; Oliver Krauss 1Division of Biochemistry And Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX. United Kingdom Search for other works by this author on: This Site PubMed Google Scholar Vicky L. Drewett; Vicky L. Drewett 1Division of Biochemistry And Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX. United Kingdom Search for other works by this author on: This Site PubMed Google Scholar Michael G. Gore Michael G. Gore 1Division of Biochemistry And Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX. United Kingdom Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1998 Biochemical Society1998 Biochem Soc Trans (1998) 26 (3): S278. https://doi.org/10.1042/bst026s278 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Oliver Krauss, Vicky L. Drewett, Michael G. Gore; Studies on the folding and unfolding of glycerol dehydrogenase from Bacillus stearothermophilus. Biochem Soc Trans 1 August 1998; 26 (3): S278. doi: https://doi.org/10.1042/bst026s278 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: CD, circular dichroism, C208H, a monomeric mutant of GDH bearing a Cys 208 to His 208 replacement This content is only available as a PDF. © 1998 Biochemical Society1998 Article PDF first page preview Close Modal You do not currently have access to this content.