gebhart/patrepeval huggingface dataset:
Rapid column‐switching liquid chromatography/mass spectrometric assay for DHEA‐sulfate in the plasma of patients with Alzheimer's disease (2006)

A simple and highly sensitive method for the quantification of dehydroepiandrosterone-3-sulfate (DHEAS) in human plasma was developed. DHEAS was directly determined in plasma using column-switching liquid chromatography/mass spectrometry (LC-MS). The plasma was filtered with a membrane filter. The filtrate was injected onto a pre-column without further sample preparation such as extraction or derivatization. The pre-column was washed with an aqueous solution to remove interference and the analyte was eluted into a reversed-phase C(18) analytical column for separation and detection using a column-switching valve. The calibration range of DHEAS was 0.01-10 micromol/L, and the linearity of the method was 0.999. The limit of detection (LOD) at a signal-to-noise (S/N) ratio of 3 was 5 nmol/L. The accuracy and precision (%CV) were less than 10% in within-day and day-to-day variations. To explore the relationship between Alzheimer's disease and the DHEAS level in human plasma, the concentrations of DHEAS in female patients with Alzheimer's disease (n = 20) and in normal female subjects (n = 20) were measured. The level of DHEAS was significantly decreased in the plasma of patients with Alzheimer's disease (p < 0.0002) compared with that in normal subjects. From the results, we concluded that our method is sufficiently sensitivity and reliability for the quantification of DHEAS in clinical samples. Plasma DHEAS concentration could be an important marker to understand the pathogenesis of Alzheimer's disease.
Synthesis of Azetidine and Pyrrolidine Derivatives through Selenium-Induced Cyclization of Secondary Homoallylamines − A77Se NMR Study (2002)

Treatment of α-alkyl and α,α-dialkyl homoallylic amines 1 with PhSeX (X = Cl, Br, I), in CH3CN containing sodium carbonate produced mixtures of azetidines 2 and pyrrolidines 3. The cyclization also occurred in the absence of Na2CO3, and the corresponding azetidinium and pyrrolidinium salts 2(HX) and 3(HX) were formed in CDCl3 or CH3CN. The crude reaction mixtures were analysed by 77Se NMR. Each product − 2, 3, 2(HX), and 3(HX) − was characterized by its 77Se chemical shift, and the product ratios were determined for each reaction. The ratios of azetidine 2 to pyrrolidine 3 increased not only according to the steric hindrance around the α-carbon, but also with the nature of the counterion X− (PhSeCl < PhSeBr < PhSeI). Use of PhSeI and amines 1g to 1k (R1, R2 ≠H), produced only the azetidinium salts 2(HI), allowing the isolation of the corresponding azetidines 2, albeit in poor yield. Some reactions were monitored by 77Se NMR at the beginning of the addition−cyclization process. No intermediates were observed when PhSeI was used, but the thermodynamic addition products 5(Br), 5(HBr), and some dibromoselenuranes 8 were detected. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
Theoretical study of the longitudinal first hyperpolarizability of polysilaacetylene (2004)

With the help of ab initio tools taking into account dynamic electron correlation effects, we study the longitudinal electronic first hyperpolarizability of carbon-silicon analogues to polyacetylene. It turns out that the MP2/6-31G(d)//HF/6-31G(d) scheme is suitable to obtain a semiquantitative accuracy for the first hyperpolarizability of long polysilaacetylene oligomers. The conformation of the chain has a crucial impact on its second-order nonlinear optical properties. We also show that, for some chain lengths, the frequency dispersion effects may have a huge impact, even when far away from resonance. These phenomena are rationalized in terms of delocalization and asymmetry.
Release of leukotriene B4 and 6-keto-prostaglandin F1 alpha from rat leukocytes in response to platelet-activating factor or Ca-ionophore A23187. (1992)

We developed an HPLC method utilizing fluorescence precolumn labeling to determine the concentration of a series of eicosanoids. LTB4 and cyclooxygenase products of arachidonic acid were derivatized with 9-anthryldiazomethane as previously reported and detected by their fluorescence in the HPLC eluate. The value measured by this method for LTB4 showed a good correlation with that obtained by RIA, as was the case for previously reported cyclooxygenase products. By this method LTB4, 6-keto-PGF1 alpha, and PGE2 were detected in the incubation medium of rat leukocytes. The leukocytes, which contained approximately 90% PMNL, were collected after intraperitoneal injection of casein, and were stimulated with Ca-ionophore A23187 or platelet-activating factor (PAF) in vitro. Release of LTB4 from 4 x 10(7) cells showed peaks of 450, 50, 23 ng at 5 min after stimulation with Ca-ionophore A23187 (12.5 microM), C16-PAF (1.0 microgram/ml), and C18-PAF (1.0 microgram/ml), respectively. The amount of 6-keto-PGF1 alpha continued to increase up to 20-40 min of incubation by those stimulators and showed respective maximum values of 100, 40, and 20 ng. The result suggests that inflammatory mediators, such as PAF, can act on inflammatory cells to release second mediators that act synergistically at the site of inflammation.
Visualization of DTI fibers using hair-rendering techniques (2006)

Diffusion Tensor Imaging (DTI) is an MRI technique that measures the diffusion of water in tissue such as white matter and muscle. From a DTI dataset, tracts representing fibers in the data can\nbe reconstructed. Because of the vast amounts of fibers that can be reconstructed from a dataset, the\nvisualization of these fibers is a challenging problem. In order to give the user a better understanding of the structure of the data, it is necessary to convey both the shapes of fibers, and the mutual coherency among multiple fibers and groups of fibers. Besides the fibers that were reconstructed, the local tensor properties, such as the second and third eigendirections and eigenvalues, are also of importance. We propose to use line illumination and shadowing of fibers in order to improve the perception of their structure. We also present a new method, inspired by the modeling of curled hair, for showing extra tensor properties along the fibers. This is done by showing curves that spirally wind around the actual fiber location, where the local tensor determines the parameters of that curve. We implemented the illumination, shadowing, and spiral curves, in such a way that the user can interact with the data and interactively change all parameters. The presented methods help\nin gaining more insight in DTI data of the brain and the heart. It is now possible to visualize more dense fiber structures using lighting and shadowing. The spiral curves help in evaluating the data where the extra tensor properties are of importance.
Urodynamics in enuretics I: Reservoir function (1989)

Abstract Cystometry appearance day and night was investigated in children with monosymptomatic nocturnal enuresis. Repeated CMG's were performed on two occasions in the awake state and once during sleep. The study revealed a low incidence of unstable bladder contractions during the day. A significantly higher incidence of unstable bladder at nighttime did not correlate to the enuretic events. Except for the occurrence of unstable bladder contractions, the mean urodynamic data for the group was reproducible. A full bladder from an otherwise normal bladder capacity triggered enuresis. The start of micturition during enuresis was shown to coincide with an abnormally low pelvic floor EMG activity.
Ag-coverage-dependent symmetry of the electronic states of the Pt(111)-Ag-Bi interface: The ARPES view of a structural transition (2011)

We studied by angle-resolved photoelectron spectroscopy the strain-related structural transition from a pseudomorphic monolayer (ML) to a striped incommensurate phase in an Ag thin film grown on Pt(111). We exploited the surfactant properties of Bi to grow ordered Pt(111)$\ensuremath{-}x$MLAg$\ensuremath{-}$Bi trilayers with $0\ensuremath{\le}x\ensuremath{\le}5$ ML, and monitored the dispersion of the Bi-derived interface states to probe the structure of the underlying Ag film. We find that their symmetry changes from threefold to sixfold and back to threefold in the Ag coverage range studied. Together with previous scanning tunneling microscopy and photoelectron diffraction data, these results provide a consistent microscopic description of the coverage-dependent structural transition.
The possibilities and limitations of heterogeneous process migration (2009)

Heterogeneous Process Migration is a technique that allows an active program to move between computers of differing architectures. While the program is executing, a migration tool will pause the program, locate the data values within the program's memory, convert them to a suitable format for the destination machine, then reconstruct the program on the destination machine so that it will continue executing correctly. Although a small number of heterogeneous migration mechanisms have been proposed, few of them have been constructed, and none have yet resulted in a mature and efficient implementation. The Tui system has been constructed to provide an efficient migration tool for use on four common architectures within the Unix environment. Implementation lessons were learned while optimizing the Tui system to gain performance. Tui has been used to derive a definition of migratibility. All other migration implementations have assumed that the program must be written in a type-safe language, or in a type-safe subset of a language. Since Tui has been designed to support heterogeneous migration of common languages that are non-type-safe, a survey of non-migratible language features has been undertaken. From this study, a definition for migratibility has been created, a framework for designing a migration tool has been given, and a comparison between migratibility and type-safety has shown that the two concepts are similar, yet different.
Synthesis of nano-porous carbon and nitrogen doped carbon dots from an anionic MOF: a trace cobalt metal residue in carbon dots promotes electrocatalytic ORR activity (2017)

Synthesis of nanoporous carbon (<bold>NPC-1</bold>) and N-doped C dots (<bold>NCD-1</bold>) has been reported from an anionic MOF. Co doping in <bold>NCD-1</bold> enhances electrocatalytic ORR activity.
Quenchable compressed graphite synthesized from neutron-irradiated highly oriented pyrolytic graphite in high pressure treatment at 1500 °C (2018)

The super hard material of “compressed graphite” (CG) has been reported to be formed under compression of graphite at room temperature. However, it returns to graphite under decompression. Neutron-irradiated graphite, on the other hand, is a unique material for the synthesis of a new carbon phase, as reported by the formation of an amorphous diamond by shock compression. Here, we investigate the change of structure of highly oriented pyrolytic graphite (HOPG) irradiated with neutrons to a fluence of 1.4 × 1024 n/m2 under static pressure. The neutron-irradiated HOPG sample was compressed to 15 GPa at room temperature and then the temperature was increased up to 1500 °C. X-ray diffraction, high-resolution transmission electron microscopy on the recovered sample clearly showed the formation of a significant amount of quenchable-CG with ordinary graphite. Formation of hexagonal and cubic diamonds was also confirmed. The effect of irradiation-induced defects on the synthesis of quenchable-CG under high pressure and high temperature treatment was discussed.
Ethics: Too much information (2010)

The EtHicS column explores issues around practising ethically in primary health care and aims to encourage thoughtfulness about ethical dilemmas that we may face.
High-Speed and Low-Power Superconducting Neuromorphic Circuits Based on Quantum Phase-Slip Junctions (2021)

The quantum phase-slip junctions (QPSJs) resulting from quantum fluctuation of superconducting order parameter in 1-D superconducting nanowires are explained as exact duals to Josephson junctions (JJs). An overdamped QPSJ can generate a current pulse to emulate a spiking event in biological neurons. We have demonstrated spiking neuron circuits and synaptic circuits using QPSJs in our previous work through simulations in WRspice. The neuron circuit can fire a current pulse as soon as the capacitor voltage is above a threshold, which is similar to an integrate-and-fire neuron (IFN). The synaptic circuit, either based on magnetic JJs and QPSJs or only using QPSJs, functions as an adjustable weighted connection between neurons. To overcome existing problems, such as fan-out limitations, and further explore the possible applications of QPSJs in superconducting neuromorphic computing, we propose new neuromorphic circuits based on QPSJs and JJs in this paper. The neuron, synapse and fan-out circuits operate through the transfer of quantized charge or fluxons, providing circuit operations that emulate brain functions. Since the fabrication of reproducible QPSJ elements remains at a preliminary stage, the demonstration of our circuits design has been primarily done in WRspice simulation with a QPSJ SPICE model.
Experimental Issues from Map Building to Trajectory Execution for a Bi-steerable Car. (2003)

voir basilic : http://emotion.inrialpes.fr/bibemotion/2003/HPSL03/ address: Coimbra (PT)
A non-square MIMO fractional robust control for the airpath of a Diesel engine (2013)

In order to minimize pollutant emissions and more specifically nitrogen oxides, a decentralized multivariable robust control has been designed for the airpath of a Diesel engine with a turbocharger, an intake throttle and Exhaust Gas Recirculation. The control system is designed with a fractional-order approach called CRONE (Commande Robust d'Ordre Non Entier) control, via a MIMO open-loop transfer function optimization, which maintains performance and robust stability for a wide set of operating points. The experimental results from a test-bench show the relevance of the proposed approach.
Micro-Milling Responses of Hierarchical Graphene Composites (2013)

The objective of this research is to examine the micro-machining responses of a hierarchical three-phase composite made up of micro-scale glass fibers that are held together by an epoxy matrix laden with nano-scale graphene platelets. To this end, micro-milling experiments are performed on both the hierarchical graphene composite as well as on a baseline two-phase glass fiber composite without the graphene additive. The composite microstructure is characterized using transmission electron microscopy and scanning electron microscopy methods. Tool wear, chip morphology, cutting force, surface roughness and delamination are employed as machinability measures. In general, the tool wear, cutting forces, surface roughness and extent of delamination are all seen to be lower for the hierarchical graphene composite. These improvements are attributed to the fact that graphene platelets improve the thermal conductivity of the matrix, provide lubrication at the tool-chip interface and also improve the interface strength between the glass fibers and the matrix. Thus, the addition of graphene to a conventional two-phase glass fiber epoxy composite is seen to not only improve its mechanical properties but also its machinability.
SAS images denoising: the jointly use of an autoadaptive mean filter and the stochastic matched filter (2007)

SAS (Synthetic Aperture Sonar) has been used in sea bed imagery. Indeed, high resolution images provided by SAS are of great interest, especially for the detection, localization or eventually classification of objects lying on sea bed. But, SAS images are highly corrupted by a granular multiplicative noise, called speckle noise, which reduces spatial and radiometric resolutions. For this reason, an automatic analysis of these images is not so evident. A solution can consist on the use of a filtering before process, without a spatial resolution degradation. The purpose of this article is to present a new process consisting on the jointly use of the stochastic matched filter and an autoadaptive mean filter. Furthermore, in order to well preserve the spatial resolution, we propose to use as a criterion for the stochastic matched filter the minimization between the speckle noise local statistics with the removal signal ones, allowing a subimage size adaptation. Results obtained on real SAS data are proposed and compared with those obtained using another stochastic matched filtering based denoising method.
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway (2009)

The small G-protein Rheb regulates cell growth via the mTORC1 complex by incompletely understood mechanisms. Recent studies document that Rheb activates mTORC1 via direct, GTP-dependent interaction with the peptidyl-prolyl-cis/trans-isomerase FKBP38, which is proposed to act as an inhibitor of mTORC1. We have conducted a comprehensive biochemical characterization of the Rheb/FKBP38 interaction. Using three different in vitro assays we did not detect an interaction between Rheb and FKBP38. Cell biological experiments illustrate that FKBP38 plays only a very minor, if any, role in mTORC1 activation. Our data document that FKBP38 is not the long-sought Rheb effector linking Rheb to mTORC1 activation.
Acute Traumatic Posteroinferior Cerebellar Artery Aneurysms: Report of Three Cases (1999)

Features of these three cases and similar cases reported in the literature support the theory that vascular ruptures and traumatic aneurysms of the proximal PICA may be related to anatomic variability of the PICA as it transverses the brainstem. This variability predisposes individuals to vascular lesions, which occur in a continuum based on the severity of the injury. Posterior fossa subarachnoid hemorrhage after head injury requires a high index of suspicion and warrants aggressive diagnostic and therapeutic interventions.
HYDRATED POTASSIUM SESQUICARBONATE, K<sub>2</sub>CO<sub>3</sub>·2KHCO<sub>3</sub>·3/2H<sub>2</sub>O (1930)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHYDRATED POTASSIUM SESQUICARBONATE, K2CO3·2KHCO3·3/2H2OArthur E. HillCite this: J. Am. Chem. Soc. 1930, 52, 10, 3817–3825Publication Date (Print):October 1, 1930Publication History Published online1 May 2002Published inissue 1 October 1930https://pubs.acs.org/doi/10.1021/ja01373a008https://doi.org/10.1021/ja01373a008research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heterologous protein production in Streptomyces lividans (2013)

Alternative hosts for expressing heterologous proteins have recently gained an increased attention. Actinomycetes, and among these especially the Streptomycetes are considered promising candidates, since they through their saprophytic lifestyle are capable of excreting large amounts of proteins. Industrially this is very useful due to the reduction of downstream processing. Streptomycetes have long been studied, and a great amount of knowledge has been gained on genetic tools and metabolism. A most promising candidate as host among the Streptomycetes is S. lividans, since this strain exhibits an exceptionally low protease activity, ensuring good product stability. Despite the fact that S. lividans has already seen industrial application studies on quantitative physiology are still lacking. It will greatly benefit the use as a common host to elucidate how S. lividans behaves in submerged cultivations, as well as how it is affected by expressing a foreign protein. In this thesis methods have been established for the study of quantitative physiology and a method for screening large amounts of carbon/nitrogen/phosphorus sources have been tested. Further, parallel to the project that is the basis of the thesis is an EU project that has had to be supported with physiological data. Cultivations have been run across laboratory relevant scales. A strong physiology platform is required to obtain the most informative results from the advanced ‘omics’ analyses. Whether the biomass is harvested from batch or chemostat experiments, reproducibility is essential for comparing results under controlled conditions.
Elasticité et cordes vocales: De la biomécanique du pli vocal à la phonation humaine (2016)

Présentation pdf diffusée en ligne, figures publiées dans la photothèque du CNRS - donnant suite à Leroux et al., CNRS Le Journal, 2017http://www.cnrs.fr/insis/recherche/docs-evenements/HommeElastique_LucieBailly.pdf
Activation of Estrogen-Responsive Genes Does Not Require Their Nuclear Co-Localization (2010)

The spatial organization of the genome in the nucleus plays a role in the regulation of gene expression. Whether co-regulated genes are subject to coordinated repositioning to a shared nuclear space is a matter of considerable interest and debate. We investigated the nuclear organization of estrogen receptor alpha (ERalpha) target genes in human breast epithelial and cancer cell lines, before and after transcriptional activation induced with estradiol. We find that, contrary to another report, the ERalpha target genes TFF1 and GREB1 are distributed in the nucleoplasm with no particular relationship to each other. The nuclear separation between these genes, as well as between the ERalpha target genes PGR and CTSD, was unchanged by hormone addition and transcriptional activation with no evidence for co-localization between alleles. Similarly, while the volume occupied by the chromosomes increased, the relative nuclear position of the respective chromosome territories was unaffected by hormone addition. Our results demonstrate that estradiol-induced ERalpha target genes are not required to co-localize in the nucleus.
Comparison of the effect of various stimuli on the leishmaniacidal capacity of human monocytes in vitro. (1984)

Leishmania organisms are obligate intracellular parasites of mammalian mononuclear phagocytes in vivo. In order to study the interactions of these parasites and mononuclear phagocytes, we have used a model of infection of Leishmania major in human monocytes in vitro. The presence of intracellular parasites did not alter the normal secretion of lysozyme or result in increased secretion of prostaglandin E2 (PGE2) or superoxide anion by the monocytes. Addition of concanavalin A (Con A), which binds to a specific membrane receptor, zymosan particles or endotoxin to infected monocyte monolayers, resulted in the expected increase in PGE2 secretion. In addition, the production of superoxide by infected monocytes treated with phorbol myristate acetate was not different from control uninfected cultures. Despite this evidence of biochemical activation, neither endotoxin, zymosan nor Con A had any parasiticidal effect on the intracellular parasites. In contrast, Con A-induced lymphokines from human mononuclear cells resulted in an increased killing of the intracellular amastigotes. These studies have shown that the induction of leishmaniacidal capacity of human monocytes is dependent on the type of stimulus used to induce activation.