gebhart/patrepeval huggingface dataset:
<i>Rhus verniciflua</i> Extract Modulates Survival of MCF-7 Breast Cancer Cells through the Modulation of AMPK-Pathway (2014)

Rhus verniciflua STOKES (RVS) is used as an anti-cancer agent in traditional herbal medicine. However, the underlying molecular mechanism of its action is poorly understood. Here, we elucidated the mechanism of the anti-cancer mechanism of RVS in MCF-7 human breast cancer cells. We found that RVS increased the phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) and suppressed cell viability in an AMPK-dependent fashion. RVS also induced an increase in reactive oxygen species (ROS) levels. RVS-induced AMPK phosphorylation was not observed in the presence of N-acetyl-cysteine (NAC), which indicated that ROS is associated with RVS-induced AMPK phosphorylation. In addition, fluorescent staining (Annexin V/propidium iodide) revealed that RVS increased the expression of Annexin V, which indicates that RVS leads to cancer-induced apoptosis. Moreover, RVS increased the phosphorylation of p53 and the expression of Bax. The inhibition of AMPK blocked RVS-induced p53 phosphorylation and Bax expression, which suggests that AMPK is involved in RVS-induced cancer apoptosis. Taken together, these results demonstrate that RVS has anti-tumor effects on MCF-7 cells through an AMPK-signaling pathway.
DNA binding proteins from <i>Tetrahymena thermophila</i> (1982)

We have used DNA-cellulose chromatography to isolate single-strand binding proteins from Tetrahymena thermophila. Three major proteins which bind to denatured DNA-cellulose were obtained. The predominant protein has a molecular weight of 20 000 in sodium dodecyl sulfate - polyacrylamide gel electrophoresis and possesses many of the properties of the helix destabilizing proteins isolated from prokaryotic and eukaryotic sources. The protein facilitates denaturation of the synthetic copolymer poly[d(A-T).d(A-T)], depressing the melting temperature by nearly 40 degrees C. It also permits the renaturation of poly[d(A-T)].d(A-T)] in high salt concentration. Two other binding proteins have molecular weight of 25 000 and 23 000 in sodium dodecyl sulfate - polyacrylamide gel electrophoresis. The protein with a molecular weight of 25 000 is probably the "M protein" previously isolated from Tetrahymena thermophila which has been shown to stimulate Tetrahymena DNA polymerase. These two proteins failed to show helix destabilizing, DNA dependent ATPase, or deoxyribonuclease activities. These three proteins are abundant in the cell with approximately 1.0 x 10(6) to 10.0 x 10(6) molecules of each protein monomer per cell. One molecule of each protein monomer binds to 7 to 10 nucleotides as detected by a nitrocellulose filter binding assay. Peptide mapping of the three proteins suggests that they are all distinct. We have also found that the binding proteins can interact with Tetrahymena DNA polymerase and some other proteins to form an enzyme complex, a putative replication complex.
Interoperation of Bluetooth and Wi-Fi Using OSGi (2011)

In this paper, a module has been presented which can perform a seamless interoperation between Bluetooth and Wi-Fi interfaces. The work is really challenging to achieve as both the interfaces work in the frequency band of 2.4 GHz creating a high possibility of interference. The challenge of implementing such an interoperable application atop OSGi framework has been discussed in this paper as well as the potential gain of such application has been highlighted. The proto-type implementation reported in this paper is an effort to validate the efficacy of the application as well as to incorporate the application in an OSGi based smart gateway in near future.
Seismic Response for Reservoir-Fluid Evaluation (1989)

Summary This paper describes a study of the relationships among lithology, pore-fluid content, stratigraphy, and the seismic response for clastic sedimentary rocks. We show how it is possible to generate seismic models from the petrophysical measurements. This procedure should provide a useful conceptual model for understanding the seismic response of a particular type of reservoir.
Tomb and epitaph of Richard III (1885)

Tomb and epitaph of Richard III Get access William Kelly, F.S.A. William Kelly, F.S.A. 1Leicester Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s6-XII, Issue 291, 25 July 1885, Pages 71–72, https://doi.org/10.1093/nq/s6-XII.291.71f Published: 25 July 1885
Distributed Approximation of Fixed-Points in Trust Structures (2015)

Recently, Carbone, Nielsen and Sassone introduced the trust-structure framework; a semantic model for trust-management in global-scale distributed systems. The framework is based on the notion of trust structures; a set of ``trust-levels'' ordered by two distinct partial orderings. In the model, a unique global trust-state is defined as the least fixed-point of a collection of local policies assigning trust-levels to the entities of the system. However, the framework is a purely denotational model: it gives precise meaning to the global trust-state of a system, but without specifying a way to compute this abstract mathematical object.<br /> <br /> This paper complements q the denotational model of trust structures with operational techniques. It is shown how the least fixed-point can be computed using a simple, totally-asynchronous distributed algorithm. Two efficient protocols for approximating the least fixed-point are provided, enabling sound reasoning about the global trust-state without computing the exact fixed-point. Finally, dynamic algorithms are presented for safe reuse of information between computations, in face of dynamic trust-policy updates.
Electrostatic field around cytochrome c: theory and energy transfer experiment. (1990)

Energy transfer in the "rapid diffusion" limit from electronically excited terbium(III) chelates in three different charge states to horse heart ferricytochrome c was measured as a function of ionic strength. Theoretical rate constants calculated by numerical integration of the Forster integral (containing the Poisson-Boltzmann-generated protein electrostatic potential) were compared with the experimental data to evaluate the accuracy of protein electrostatic field calculations at the protein/solvent interface. Two dielectric formalisms were used: a simple coulombic/Debye-Hückel procedure and a finite difference method [Warwicker, J. & Watson, H. C. (1982) J. Mol. Biol. 157, 671-679] that accounts for the low-dielectric protein interior and the irregular protein/solvent boundary. Good agreement with experiment was obtained and the ionic-strength dependence of the reaction was successfully reproduced. The sensitivity of theoretical rate constants to the choices of effective donor sphere size and the energy transfer distance criterion was analyzed. Electrostatic potential and rate-constant calculations were carried out on sets of structures collected along two molecular dynamics trajectories of cytochrome c. Protein conformational fluctuations were shown to produce large variations in the calculated energy transfer rate constant. We conclude that protein fluctuations and the resulting transient structures can play significant roles in biological or catalytic activities that are not apparent from examination of a static structure. For calculating protein electrostatics, large-scale low-frequency conformational fluctuations, such as charged side-chain reorientation, are established to be as important as the computational method for incorporating dielectric boundary effects.
Auf das Zentralnervensystem wirkende Substanzen, XXII. 2‐Phenyl‐azetidin und Derivate (1962)

Abstract 2‐Phenyl‐azetidin (I) wurde durch LiAlH 4 ‐Reduktion des 2‐Phenyl‐azetidinons‐(4) (III) erhalten. Die chemischen und physikalischen Eigenschaften wurden näher untersucht und mehrere N‐Derivate dargestellt. Die Ergebnisse ermöglichen Schlußfolgerungen über die Beständigkeit viergliedriger Heterocyclen.
Evolving neural networks (2013)

Neuroevolution, i.e. evolution of artificial neural networks, has recently emerged as a powerful technique for solving challenging reinforcement learning problems. Compared to traditional (e.g. value-function based) methods, neuroevolution is especially strong in domains where the state of the world is not fully known: The state can be disambiguated through recurrency, and novel situations handled through pattern matching. In this tutorial, I will review (1) neuroevolution methods that evolve fixed-topology networks, network topologies, and network construction processes, (2) ways of combining traditional neural network learning algorithms with evolutionary methods, and (3) applications of neuroevolution to control, robotics, artificial life, and games.
GLOBAL ATTRACTORS IN ABSTRACT PARABOLIC PROBLEMS (London Mathematical Society Lecture Note Series 278) <i>By</i> J<scp>AN</scp> W. C<scp>HOLEWA</scp> and T<scp>OMASZ</scp> D<scp>LOTKO</scp>: 235 pp., £27.95 (LMS members' price £20.96), <scp>ISBN</scp> 0-521-79424-2 (Cambridge University Press, 2000). (2001)

GLOBAL ATTRACTORS IN ABSTRACT PARABOLIC PROBLEMS (London Mathematical Society Lecture Note Series 278) By JAN W. CHOLEWA and TOMASZ DLOTKO: 235 pp., £27.95 (LMS members' price £20.96), ISBN 0-521-79424-2 (Cambridge University Press, 2000). - Volume 33 Issue 6
ORIGINAL ARTICLE: Genistein Reverses Diminished T‐Cell Signal Transduction, Induced by Post‐Menopausal Estrogen Levels (2008)

Genistein restores CD3zeta, NFkappaB and JAK3 proteins and mRNAs at post-meonopausal estrogen levels, in vitro, with no significant effect at pre-menopausal estrogen levels.
A New Crystal Modification of Chromium Tetrafluoride: β-CrF4 (2002)

Slow thermal decomposition of CrF5 at 403 K affords a new crystal modification of CrF4. The basic units in the crystal structure of this β-CrF4 are tetrameric rings formed by four corner-sharing CrF6 octahedra (see picture), which are linked together to form isolated columns running along the c axis.
ChemInform Abstract: Synthesis and Biological Effects of Novel N,N‐Disubstituted 5‐ Alkyliden‐ and 5‐Aralkyliden‐3‐aminorhodanines. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chlamydia-dependent biosynthesis of a heparan sulphate-like compound in eukaryotic cells (2000)

One hypothesis for the mechanism of chlamydial interaction with its eukaryotic host cell invokes a trimolecular mechanism, whereby a Chlamydia-derived glycosaminoglycan bridges a chlamydial acceptor molecule and a host receptor enabling attachment and invasion. We show that a heparan sulphate-specific monoclonal antibody specifically binds a glycosa-minoglycan localized to the surface of the chlamydial organism and effectively neutralizes infectivity of both C. trachomatis and C. pneumoniae. In addition to the ability of this antibody to neutralize infectivity, direct visualization using immunofluorescence demonstrated staining of chlamydial organisms localized to the intracellular vacuole. The chlamydial-associated glycosaminoglycan was specifically labelled with [14C]-glucosamine, and the labelled compound was immunoprecipitated and resolved by gel electrophoresis. The chlamydial-associated glycosaminoglycan is a high-molecular-weight compound similar in size to heparin or heparan sulphate and was sensitive to cleavage by heparan sulphate lyase. These data demonstrate that a glucosamine-containing sulphated polysaccharide is produced within the intracellular vacuole containing chlamydiae and is a target for antibody-mediated neutralization of infectivity.
Continuous operation of foamed emulsion bioreactors treating toluene vapors (2005)

Continuous operation of a new bioreactor for air pollution control called the foamed emulsion bioreactor (FEBR) has been investigated. The effect of several liquid feeding strategies was explored. The FEBR exhibited high and steady toluene removal performance (removal efficiency of 89%-94%, elimination capacity of 214-226 g/m3h at toluene inlet concentration of 1 g/m3) for up to 360 h, when 20% of the culture was replaced every 24 h by a nutrient solution containing 4 g/L of potassium nitrate as a nitrogen source. This feeding mode supported a high cell activity measured as INT reduction potential and active cell growth without being subject to nitrogen limitation. In comparison, operating the FEBR with the liquid in a closed loop (i.e., batch) resulted in a significant decrease of both the removal efficiency of toluene and INT reduction activity. Operation with feeding active cells resulted in stable and effective treatment, but would require a significant effort for mass culture preparation. Therefore, the continuous process with periodically feeding nutrients was found to be the most practical and effective operating mode. It also allows for stable operation, as was shown during removal of low concentration of toluene or after pollutant starvation. Throughout the study, INT reduction measurements provided insight into the process. INT reduction activity data proved that under normal operating conditions, the FEBR performance was limited by both the kinetics and by mass transfer. Overall, the results illustrate that engineered gas-phase bioreactors can potentially be more effective than conventional biofilters and biotrickling filters for the treatment of air pollutants such as toluene.
Synthesis of o-brominated diaryl ethers using symmetrical iodonium salts: Application to the synthesis of Bastadin precursors (2004)

The coupling of o-brominated phenols with symmetrical iodonium salts for the construction of the corresponding diaryl ethers was studied. Bis-(2-benzyloxy-5-formyl-phenyl)-iodonium bromide 6b, only once mentioned in the literature, was fully characterized and tested for the synthesis of Bastadin related diaryl ethers.
An integrated task management system to reduce semantic conflicts in multi-user computer-aided design (2015)

Simultaneous multi-user computer-aided design enables teams of designers to contribute simultaneously to the same model. As multiple users make contributions to the model, all users see additions from all other collaborators in real-time. However, without careful coordination, conflicts that violate the design intent of the model may occur. These are referred to as semantic conflicts and lead to redundant work by users. This article presents a method to reduce semantic conflicts through a task management system integrated directly into multi-user computer-aided design. Experiments were run that compare multi-user teams’ design modeling times with and without the integrated task management system. The results of these experiments show that the integrated task management system significantly reduces the time to complete design models by reducing semantic conflicts through enhanced organization and communication.
Implications of erbB-2 overexpression for basic science and clinical medicine. (1990)

Overexpression of the Epidermal Growth Factor (EGF) Receptor gene and the related erbB-2 gene has been identified in human cancers derived from a variety of tissues. The overexpression of the encoded growth factor receptor proteins is functionally related to the development of the tumor. This observation has important potential consequences for the improved diagnosis and treatment of cancer. Overexpression of these proteins also provides experimental systems that facilitate the study of growth factor signal transduction.
Mixed micelles of block copolymers of ethylene oxide and 1,2-butylene oxide. Solutions and gels of triblock BEB plus diblock EB copolymers studied by light scattering and rheology (2003)

Because of the hydrophobic end blocks, micelles of triblock BEB copolymers (E denotes an oxyethylene unit, B an oxybutylene unit) formed in aqueous solution show effects attributable to intermicellar bridging. The formation of mixed micelles with a diblock EB copolymer reduces but does not eliminate the effect. Light scattering methods applied to dilute solutions have been used to show that this is the case for mixed micelles of B12E114B12 and E43B11 (the subscripts denote block lengths). This work focuses on 20 wt% aqueous solutions and on the effect of mixing on properties relating to the gel state, i.e. dynamic storage modulus (G′) and yield strength (σy). There are two contributory factors determining the gel properties: micelle bridging and micelle packing, with just the latter operative for a diblock gel. Increasing the proportion of diblock copolymer in the mixture reduces the contribution from micelle bridging. Considering 20 wt% solutions at 5 °C, the diblock copolymer solution does not gel at this temperature and values of G′ and σy fall away monotonically to zero. For 20 wt% solutions at 25 °C, the diblock copolymer solution does gel at this temperature and values of G′ and σy pass through minima as the system is changed from 100% triblock to 100% diblock copolymer.
Heuristic Search in Dual Space for Constrained Stochastic Shortest Path Problems (2016)

We consider the problem of generating optimal stochastic policies for Constrained Stochastic Shortest Path problems, which are a natural model for planning under uncertainty for resource-bounded agents with multiple competing objectives. While unconstrained SSPs enjoy a multitude of efficient heuristic search solution methods with the ability to focus on promising areas reachable from the initial state, the state of the art for constrained SSPs revolves around linear and dynamic programming algorithms which explore the entire state space. In this paper, we present i-dual, which, to the best of our knowledge, is the first heuristic search algorithm for constrained SSPs. To concisely represent constraints and efficiently decide their violation, i-dual operates in the space of dual variables describing the policy occupation measures. It does so while retaining the ability to use standard value function heuristics computed by well-known methods. Our experiments on a suite of PPDDL problems augmented with constraints show that these features enable i-dual to achieve up to two orders of magnitude improvement in run-time and memory over linear programming algorithms.
EPILEPSY. (1892)

Admitting that from the time of Aristotle, when a knowledge of the structure and functions of the human body first began to be cultivated systematically, down to the present day the demonstrator of morbid anatomy has not lived who can point with unerring finger to the cause of epilepsy; admitting, too, that of more than eight millions of the world's people, whom statistics prove to be epileptics, perhaps less than one third are curable; yet we claim that in our thirty years' experience, both in Europe and in the United States, we have not been without some measure of success in the treatment of epileptics who continue to report themselves free from fits. In response to a request for a chapter from our own experience in the treatment of epilepsy, leaving its etiology, pathology and history to fhe many able medical writers of the day, we purpose giving a brief
Transarterial chemoembolization (TACE) with degradable starch microspheres (DSM) in hepatocellular carcinoma (HCC): multi-center results on safety and efficacy (2017)

The use of DSM as a TACE embolic agent appears to be safe for the treatment of HCC and has promising efficacy.
Picosecond coherent anti-Stokes Raman scattering from the excited states of stilbene and benzophenone (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPicosecond coherent anti-Stokes Raman scattering from the excited states of stilbene and benzophenoneStephen A. Payne and Robin M. HochstrasserCite this: J. Phys. Chem. 1986, 90, 10, 2068–2074Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/j100401a019https://doi.org/10.1021/j100401a019research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
MLSE for an unknown channel. II. Tracking performance (1996)

For pt. I see ibid., vol.44, no.7, p.836, 1996. The channel-tracking mode performance of the front-end (FE) processors is determined through approximate analysis and computer simulation. A general model for the FE processing, which encompasses these representative FEs, is assumed. Previous analysis techniques are extended to include the effects of FE processing. The specific system analyzed consists of a Rayleigh-fading, diffuse multipath channel, with several data pulse shapes considered. An adaptive maximum likelihood sequence estimation (MLSE) algorithm based on the per-survivor processing (PSP) technique is analyzed and compared to an algorithm based on correct symbol feedback. The results show that significant performance degradation is suffered when suboptimal FE processing is used. Some of the issues which may complicate matters in practice are examined with an emphasis on application in packet mobile radio systems. The limitations of the results and the models used are discussed.
Lack of correlation between effects of tentoxin on chloroplast coupling factor and chloroplast ultrastructure (1986)

The mediation of tentoxin‐induced chlorosis through inhibition of chloroplast coupling factor 1 (CF 1 ) ATPase activity was investigated through an examination of the effects of tentoxin on electrophoretically‐separated CF 1 ATPases from sensitive and insensitive Nicotiana species. Sensitive species exhibited three major ATPases, only one of which was inhibited at some concentrations of tentoxin. Insensitive Nicotiana species showed the same three “isozymes”upon electrophoresis but none of the isozymes were tentoxin sensitive. CF 1 isolated from Zea mays L. cv. Pioneer 3541, which is insensitive to tentoxin in vivo based on lack of chlorosis, exhibited two ATPases, one of which was sensitive to tentoxin. The concentration/activity relationships between tentoxin and ATPase inhibition of the sensitive isozyme did not correlate well with the chlorosis induced at similar levels of tentoxin in vivo. Both Oenothera hookeri Torr. & Gray and the CF 1 ‐deficient I iota mutant derived from it are sensitive to tentoxin as determined by loss of chlorophyll and ultrastructural changes typical of the tentoxin syndrome. These results support a mechanism of action different from inhibition of CF 1 for tentoxin‐induced chlorosis.