gebhart/patrepeval huggingface dataset:
Target recognition by calmodulin: Dissecting the kinetics and affinity of interaction using short peptide sequences (1996)

The interaction between calmodulin (CaM) and peptide M13, its target binding sequence from skeletal muscle myosin light chain kinase, involves predominantly two sets of interactions, between the N-terminal target residues and the C-domain of calmodulin, and between the C-terminal target residues and the N-domain of calmodulin (Ikura M et al., 1992, Science 256:632-638). Using short synthetic peptides based on the two halves of the target sequence, the interactions with calmodulin and its separate C-domain have been studied by fluorescence and CD spectroscopy, calcium binding, and kinetic techniques. Peptide WF10 (residues 1-10 of M13) binds to CaM with Kd approximately 1 microM; peptide FW10 (residues 9-18 of M13, with Phe-17-->Trp substitution) binds to CaM with Kd approximately 100 microM. The effect of peptide WF10 on calcium binding to calmodulin produces a biphasic saturation curve, with marked enhancement of affinity for the binding of two calcium ions to the C-domain, forming a stable half-saturated complex, Ca2-CaM-peptide, and confirming the functional importance of the interaction of this sequence with the C-domain. Stopped-flow studies show that the EGTA-induced dissociation of WF10 from Ca4-CaM proceeds by a reversible relaxation mechanism from a kinetic intermediate state, also involving half-saturation of CaM, and the same mechanism is evident for the full target peptide. Interaction of the N-terminal target residues with the C-domain is energetically the most important component, but interaction of calmodulin with the whole target sequence is necessary to induce the full cooperative interaction of the two contiguous elements of the target sequence with both N- and C-domains of calmodulin. Thus, the interaction of calmodulin with the M13 sequence can be dissected on both a structural and kinetic basis into partial reactions involving intermediates comprising distinct regions of the target sequence. We propose a general mechanism for the calcium regulation of calmodulin-dependent enzyme activation, involving an intermediate complex formed by interaction of the calmodulin C-domain and the corresponding part of the target sequence. This intermediate species can function to regulate the overall calcium sensitivity of activation and to determine the affinity of the calmodulin target interaction.
Selective inter-layer residual prediction for SVC-based video streaming (2009)

The scalable video coding (SVC) standard adopts the inter-layer residual prediction (ILRP) algorithm to encode the residual signal of the enhancement layer (EL). The ILRP reduces the number of bits required for encoding the residual signal but incurs excessive encoding time. In this paper, we propose a fast encoding algorithm for SVC-based video streaming. In this algorithm, the ILRP is selectively applied to the coding modes depending on their Lagrangian rate-distortion costs. Experimental results show that the proposed algorithm can reduce computational complexity with negligible video quality degradation and bitrate increments.
Biosynthesis of pyocyanin pigment by Pseudomonas aeruginosa (2014)

Sixty-three isolates belonging to the genus Pseudomonas were isolated from different environmental sources including; soil, water and clinical specimens. Twenty out of them were identified as Pseudomonas aeruginosa and individually screened for pyocyanin production. P. aeruginosa R1; isolated from rice-cultivated soil and P. aeruginosa U3 selected from clinical specimen (Urinary tract infection) were the highest pyocyanin producers; pyocyanin production reached 9.3 and 5.9 μg/ml, respectively on synthetic glucose supplemented nutrient medium (GSNB). The identification of both selected strains (P. aeruginosa R1 and P. aeruginosa U3) was confirmed by 16S rRNA, the similarity with other strains available in database was 97% (with P. aeruginosa FPVC 14) and 94% (with P. aeruginosa 13.A), respectively. P. aeruginosa R1 and P. aeruginosa U3 are accessed at gene bank with accession numbers KM924432 and KM603511, in the same order. Pyocyanin was extracted by standard methods, purified by column chromatography and characterized by UV-Vis absorption, mass spectrometry and nuclear magnetic resonance. The antimicrobial activity of purified pyocyanin against multi-drug resistant microbes was investigated; the efficiency of pyocyanin was more obvious in Gram +ve bacteria than Gram−ve bacteria and yeast. To reduce the cost of pyocyanin production, a new conventional medium based on cotton seed meal supplemented with peptone was designed. The pyocyanin production of both selected strains P. aeruginosa R1 and P. aeruginosa U3 using the new medium is increased by 30.1% and 17.2%, respectively in comparison with synthetic GSNB medium, while the cost of production process is reduced by 56.7%.
Influence of Wood Hardness on Feeding by the Eastern Subterranean Termite, Reticulitermes flavipes (Isoptera: Rhinotermitadae)1 (1972)

Reticulitermes flavipes (Kollar) fed on diffuse porous hardwoods in inverse proportion to their hardness, as measured on the lateral surface. A similar relationship was found between weight loss due to termite feeding and specific gravity of the wood. These results held for one-species tests as well as paired-species tests.
A level-set method for magnetic substance simulation (2020)

We present a versatile numerical approach to simulating various magnetic phenomena using a level-set method. At the heart of our method lies a novel two-way coupling mechanism between a magnetic field and a magnetizable mechanical system, which is based on the interfacial Helmholtz force drawn from the Minkowski form of the Maxwell stress tensor. We show that a magnetic-mechanical coupling system can be solved as an interfacial problem, both theoretically and computationally. In particular, we employ a Poisson equation with a jump condition across the interface to model the mechanical-to-magnetic interaction and a Helmholtz force on the free surface to model the magnetic-to-mechanical effects. Our computational framework can be easily integrated into a standard Euler fluid solver, enabling both simulation and visualization of a complex magnetic field and its interaction with immersed magnetizable objects in a large domain. We demonstrate the efficacy of our method through an array of magnetic substance simulations that exhibit rich geometric and dynamic characteristics, encompassing ferrofluid, rigid magnetic body, deformable magnetic body, and multi-phase couplings.
Alcohol-Induced Brain Pathology and Behavioral Dysfunction: Using an Animal Model To Examine Sex Differences (2000)

Background: Human epidemiological studies suggest that the female brain may be more susceptible to the toxic effects of alcohol and that this is the reason why women show greater behavioral dysfunction after chronic alcohol exposure. This hypothesis was tested by using a rat model of chronic alcoholism [chronic ethanol treatment (CET)]. The investigation assessed sex differences in neuropathology and behavior after chronic exposure and subsequent withdrawal from alcohol. Methods: Young male and female rats (∼3 months old) were assigned to either a CET group, which received a 20% ethanol drinking solution for 20 weeks, or a pair-fed control group, which received ad libitum tap water and a restricted diet for 20 weeks. After the CET groups were phased off the 20% alcohol solution, learning and memory abilities were examined by using matching-to-position and nonmatching-to-position tasks. Neuropathology was assessed in the frontal cortex and medial septal region. Results: CET was shown to cause behavioral deficits. The behavioral dysfunction was sex, task, and process dependent; i.e., CET-female rats displayed a delay-dependent impairment on delayed matching-to-position, whereas CET-male rats displayed a delay-independent impairment on delayed nonmatching-to-position. CET resulted in a significant reduction in the frontal cortical (FR1) and collosal thickness, as well as a decrease in cells staining immunopositive for choline acetyltransferase in the medial septal region. However, relative to male rats exposed to CET, female rats did not show any accelerated neuropathology after CET. Conclusions: Chronic exposure to ethanol does result in both brain and behavior dysfunction in male and female rats. The results demonstrate that different cognitive processes are altered by chronic ethanol exposure in male and female rats. However, the neurobiological mechanisms responsible for these differences remain to be determined.
HC96 Conference (1996)

CIN: Computers, Informatics, Nursing serves to advance the science of nursing informatics through peer-reviewed, evidence-based, original research and information from clinical and educational settings, to promote the specialty by disseminating information about relevant professional nursing informatics activities, and to provide a resource for all involved in the implementation and management of health information technology within the nursing and healthcare practice. About the Journal: For over 30 years, CIN: Computers, Informatics, Nursing has been at the interface of the science of information and the art of nursing, publishing articles on the latest developments in nursing informatics, research, education and administrative of health information technology. CIN connects you with colleagues as they share knowledge on implementation of electronic health records systems, design decision-support systems, incorporate evidence-based healthcare in practice, explore point-of-care computing in practice and education, and conceptually integrate nursing languages and standard data sets. Continuing education contact hours are available in every issue.
Complexes métalliques du bis [2-[(Carboxyméthyl)Thio]éthyl]éther (1977)

On a étudié potentiométriquement l’équilibre de dissociation du coordinal bis[2-[(carboxyméthyl)thio]éthyl]éther et les équilibres de formation de ses complexes 1 :1 avec Ag, Cu, Cd, Co, Ni, Zn, Pd (II) et Pt (II).
The behaviour of explosives at very high temperatures (1961)

J. Wenograd, Trans. Faraday Soc., 1961, 57, 1612 DOI: 10.1039/TF9615701612
Robust Learning at Noisy Labeled Medical Images: Applied to Skin Lesion Classification (2019)

Deep neural networks (DNNs) have achieved great success in a wide variety of medical image analysis tasks. However, these achievements indispensably rely on the accurately-annotated datasets. If with the noisy-labeled images, the training procedure will immediately encounter difficulties, leading to a suboptimal classifier. This problem is even more crucial in the medical field, given that the annotation quality requires great expertise. In this paper, we propose an effective iterative learning framework for noisy-labeled medical image classification, to combat the lacking of high quality annotated medical data. Specifically, an online uncertainty sample mining method is proposed to eliminate the disturbance from noisy-labeled images. Next, we design a sample re-weighting strategy to preserve the usefulness of correctly-labeled hard samples. Our proposed method is validated on skin lesion classification task, and achieved very promising results.
Reconfigurable robotic system based on mono-camera guidance (2014)

The paper proposes an intelligent robotic system which is able to be (re)configured, at demand, for two deployment scenarios. a) The first task is to move the platform after a trajectory determined by the direction to a fixed point and avoid any obstacles occurring in the route. a) The second task is to identify and track a spherical object. The robot is equipped with a navigation system designed to maintain direction in case of interruption of video contact with the target (landmark), meaning when an obstacle interposes. It has two main subsystems: the mobile platform, which is equipped with a video camera and sensors for path correction, and the central processing system for the analysis of received information. The task control is based on extracted features from images. The communication between them is done via a wireless protocol. Algorithms for controlling the mobile platform are implemented on the embedded microcontroller and algorithms for image processing are implemented on the central system.
The radioactivity of the human body (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe radioactivity of the human bodyIsaac Asimov Cite this: J. Chem. Educ. 1955, 32, 2, 84Publication Date (Print):February 1, 1955Publication History Received3 August 2009Published online1 February 1955Published inissue 1 February 1955https://doi.org/10.1021/ed032p84RIGHTS & PERMISSIONSArticle Views251Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (939 KB) Get e-Alerts Get e-Alerts
Soluble VEGF/sFLt1 ratio is an independent predictor of AML patient out come (2005)

Angiogenesis is the formation of new blood vessels and is controlled by a balance between positive and negative angiogenic regulatory factors. Soluble vascular endothelial growth factor receptors 1,2 (Flt-1, KDR) are the negative counterpoint to the vascular endothelial growth factor (VEGF) signaling pathway, which has been characterized as one of the most important endothelial regulator in human angiogenesis. In the present work, we tested the differential prognostic relevance of soluble vascular endothelial growth factor (VEGF), their receptors 1 (Flt-1), 2 (KDR), and the ratio between sVEGF/sFlt-1 in 43 patients with acute myeloid leukemia (AML). sVEGF and its soluble receptors were assessed using an ELISA. Soluble VEGF, sFLT-1 and sKDR concentration levels were significantly higher in AML patients at diagnosis when compared to the levels in normal controls. sVEGF, sFlt1 and the sVEGF/sFlt1 ratio were significantly higher in non responders when compared to responders (P < 0.001 for all). However, there was no significant difference regarding sKDR levels (P > 0.05). sVEGF, the sVEGF/sFlt1 ratio but not sFlt1 and sKDR levels were significantly elevated in those who did not survive, when compared to survivors. sVEGF, sFlt1 levels were significantly correlated to WBC counts (R = 0.93, P = 0.000, R = 0.56, P = 0.000, respectively); bone marrow blast cell counts (R = 0.92, P = 0.000; R = 56, P = 0.000, respectively); peripheral blood blast cell counts (R = 0.91, P = 0.000; R = 0.52, P = 0.000, respectively); sKDR was only correlated to peripheral blood blast cell counts(R=0.37,P=0.014). Cox regression analysis results with sVEGF, sFlt1, sKDR, sVEGF/sFlt1 ratio suggest that the most important predictor for AML outcome is the sVEGF/sFlt1 ratio. In conclusion, sVEGF/sVEGF ratio is independent predictor of AML patient out come, and its significance should be assessed when considering antiangiogenic therapy.
Pancreatic islet blood flow and its measurement (2016)

Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to maintain and support the internal milieu of the islets favoring normal endocrine function. Islet blood flow is normally very high compared with that to the exocrine pancreas and is autonomously regulated through complex interactions between the nervous system, metabolites from insulin secreting β-cells, endothelium-derived mediators, and hormones. The islet blood flow is normally coupled to the needs for insulin release and is usually disturbed during glucose intolerance and overt diabetes. The present review provides a brief background on islet vascular function and especially focuses on available techniques to measure islet blood perfusion. The gold standard for islet blood flow measurements in experimental animals is the microsphere technique, and its advantages and disadvantages will be discussed. In humans there are still no methods to measure islet blood flow selectively, but new developments in radiological techniques hold great hopes for the future.
MUMPS VIRUS IN HUMAN MILK AND IN MILK OF INFECTED MONKEY (1951)

Detection of mumps virus in the milk of a mother with epidemic parotitis at the time of delivery is of clinical interest, as this virus, to my knowledge, has not been hitherto isolated from this source. Mastitis is rarely listed among the manifestations of mumps. As described below, mumps virus was also detected in the milk of a lactating monkey in whom infection had been artificially induced. REPORT OF A CASE E. M., a 23 year old Negro woman, was admitted to the hospital 1 on May 2, 1950, for parotitis of two days' duration. She had bilateral swelling and edema in the parotid areas. Mumps had developed in two of her children in the preceding three weeks. Shortly after arrival, the patient was delivered of a full term, normal infant. A sample of milk was obtained three days later at the onset of lactation, when the mother's breasts were
Zur Kenntnis der Thiopyryliumsalze (1956)

Abstract 2,4,6‐Triarylpyryliumsalze lassen sich mit Natriumsulfid in Aceton leicht in Triarylthiopyryliumsalze überführen. Diese sind noch tieferfarbig als die analogen Pyryliumsalze. Die Beziehungen zwischen Konstitution und Farbe werden kurz besprochen. Die neue Methode ist auch auf die Vinylenhomologen der Triarylpyryliumsalze anwendbar.
GPU-Accelerated Protein Family Identification for Metagenomics (2013)

The clustering of putative protein/Open Reading Frame (ORF) sequences available from large-scale metagenomics survey projects is a core analytical function that has led to the identification and characterization of novel protein families of environmental microbial communities. The implementation of this function, however, is currently challenged not only by data size but also by data complexity. In this paper, we present a CPU-GPU implementation of a randomized graph clustering heuristic called Shingling, which was originally developed by Gibson et al. Our implementation uses the CPU and GPU for different stages of computation, using GPUs for the most time-consuming steps. Experimental results of a 2M ocean metagenomics data set obtained from the Sorcerer II Global Ocean Sampling project show that our new implementation is able to achieve a ~7X speedup over our serial implementation without using asynchronous CPU-GPU communication, with the GPU part alone contributing to over ~374X speedup in the accelerated part. Qualitative evaluation of the 2M data set shows that our method is able to improve sensitivity of clustering over existing methods, and is more successful in recruiting more sequences into the clustering without impacting the overall specificity. As a demonstration of a large scale run, we were able to cluster a real world homology graph, containing 11M vertices and 640M edges, and constructed from sequences of an ongoing Pacific Ocean metagenomics survey project, in about 94 minutes.
Ammonium Repression of Extracellular Protease in Aspergillus nidulans (1972)

Summary Extracellular protease of Aspergillus nidulans is repressible by ammonium. A mutant (xprDI) selected for derepression of protease in the presence of ammonium is also derepressed for nitrate reductase, xanthine dehydrogenase and glutamate uptake; it retains the ability to use ammonium as sole nitrogen source. The mutant is partially dominant in heterozygous diploids. The mutation does not confer methylamine resistance, nor are methylamine-resistant(meaA) strains derepressed for protease.
Outage Probability of Cognitive DF Relay Systems over Nakagami-<i>m</i> Fading (2019)

This paper aims to derive accurate outage probability expressions of a cognitive decode-and-forward (DF) relay system over the Nakagami- m fading channel. A secondary system and a primary system coexist in a spectrum sharing the environment. In order to protect the data transmission of the primary system, the transmission power of the secondary system cannot exceed the tolerable interference threshold of the primary system and its available peak power. In particular, we also consider the impact on the secondary system when the primary system turns on its transmitter. Simulation results align with our theoretical formulas very well.
17-α Hydroxyprogesterone Caproate for the Prevention of Preterm Birth (2011)

17 α hydroxyprogesterone caproate is a synthetic form of the natural progestin 17-α hydroxyprogesterone that is US FDA approved for the prevention of recurrent spontaneous preterm birth in women with a history of a prior singleton preterm birth. For women with a history of a prior spontaneous preterm birth between 20 weeks and 36 weeks and 6 days of gestation, the use of 17-α hydroxyprogesterone caproate has been shown to reduce the risk of recurrent preterm birth by more than 30%. This medication is the only drug currently FDA approved for the prevention of preterm birth, and it is the first drug the FDA has approved for use exclusively during pregnancy in approximately 15 years.
Effect of skewing the rotor teeth on the performance of doubly salient permanent magnet motors (2006)

This paper presents the effects of skewing the rotor teeth on the performance characteristics such as flux linkage, back emf, phase inductance, and reluctance torque of an 8∕6 doubly salient permanent magnet motor using a simple method, which utilizes the results obtained from the two-dimensional finite element analysis. The optimum skewing angle is obtained as 12°–15° for the least ripple torque without much reduction in the back emf. Skewing the rotor teeth of an 8∕6 doubly salient permanent magnet motor by 12°–15° will reduce the total harmonic distortion of the back emf profile to 29.69% from the original value of 44.69%. The reduction in the amplitude of the back emf in this case will be 18.79% only.
A distributed merger for ATM (1990)

Several designs for a merger are possible, but a good design should fulfil the following requirements: flexibility, modularity, fair and efficient merging algorithm, small delay and small buffers. The first requirement implies that the merger should be able to cope with the specific characteristics of every block where it is needed; this means, for example, that the merger can be used either with high bit rate sources (e.g. video) or low bit rate sources (e.g. low speed data). The second requirement means that the merger should have an architecture that could be easily upgraded without significant performance degradation, in order to accommodate more sources. Finally, the last three requirements are related with the performance of the merger itself and represent the goals that the merger design should attain. The authors describe a merger distributed architecture which satisfies all the stated requirements. >
Variable size block matching motion compensation for object-based video coding (1997)

Previously developed object-based video coding schemes require the estimation of motion in arbitrary-shaped objects. A quad-tree structured variable size block matching technique is described. The inherent motion is represented by significantly fewer blocks than if conventional fixed size block matching had been used to provide a similar quality prediction.