gebhart/patrepeval huggingface dataset:
Aminophylline for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (1987)

The forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) before and after metaproterenol inhalation were measured twice daily by a blinded investigator, who also administered a verbal dyspnea index with a scale of 1 to 10 and questioned patients regarding possible side effects of treatment (tremor, palpitations, nausea, or vomiting). Arterial blood gas measurements at 72 hours were compared with those obtained on admission. Significant improvements in FEV1 and FVC measured before and after metaproterenol treatment and in dyspnea occurred over time in both treatment groups (p less than 0.05 for all measurements). However, there were no significant differences between the placebo and aminophylline groups in any of the spirometric measurements or the dyspnea indices (p greater than 0.5 in all five analyses). The mean increases (+/- SE) in Po2 of 1.9 (+/- 0.5) kPa with placebo and 1.7 (+/- 0.7) kPa with aminophylline and the mean decreases in PCO2 of 0.5 (+/- 0.4) kPa with placebo and 1.2 (+/- 0.4) kPa with aminophylline were not significantly different (p greater than 0.6 for PO2, p greater than 0.2 for PCO2).(ABSTRACT TRUNCATED AT 400 WORDS)
Semiconducting Polymer Dots Doped with Europium Complexes Showing Ultranarrow Emission and Long Luminescence Lifetime for Time‐Gated Cellular Imaging (2013)

Helle Punkte: Die im Titel beschriebenen Polymerpunkte haben eine hohe Quantenausbeute bei langen Fluoreszenzlebensdauern. Die Polymerpunkte markieren Rezeptoren auf Zellen und können anhand ihrer langen Fluoreszenzlebensdauern von anderen rot fluoreszierenden Nanopartikeln durch zeitgesteuerte Bildgebung unterschieden werden. PVK=Poly(9-vinylcarbazol). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
EVALUATION OF THE COSTS OF STORM WATER COMPLIANCE FOR THREE MIDWESTERN RESIDENTIAL DEVELOPMENTS (2008)

EVALUATION OF THE COSTS OF STORM WATER COMPLIANCE FOR THREE MIDWESTERN RESIDENTIAL DEVELOPMENTSThe impact of stream buffer and storm water detention and water quality ordinances on per lot development costs for moderate sized residential developments were assessed by developing separate pre- and post-ordinance designs for three typical residential developments with small to medium lot sizes.Author(s)Chad W. SayreJohn L. HolmesCass MathewsKathleen M. TrauthSourceProceedings of the Water Environment FederationSubjectSession 73: Watershed Management ApproachesDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2008ISSN1938-6478SICI1938-6478(20080101)2008:10L.5702;1-DOI10.2175/193864708788807222Volume / Issue2008 / 10Content sourceWEFTECFirst / last page(s)5702 - 5721Copyright2008Word count56
Molecular Mechanism of ESCRT‐III Filament Formation (2015)

The ESCRT pathway mediates a series of important cellular membrane remodeling and fission events, including cytokinetic abscission. During these processes, ESCRT-III family proteins form filaments that appear to constrict membranes and facilitate fission. We have used electron cryomicroscopy to determine the near-atomic resolution structure of helical double-stranded filaments formed by two homologous human ESCRT-III subunits that function in abscission, CHMP1B and IST1. The inner strand comprises interlocking CHMP1B subunits that adopt extended, open conformations, whereas the outer strand comprises closed, compact IST1 subunits. The double-stranded CHMP1B-IST1 filaments can also form constricting conical spirals in which adjacent turns of the spiral interact through a continuum of related but inequivalent electrostatic interactions that allow the spiral to adjust its diameter continuously. We speculate that the ability to form conical spirals allows the filaments to draw membranes together to the point of fission.
Regulation of the Uterine Expression of Messenger Ribonucleic Acids Encoding the Oestrogen Receptor and IGF–I Peptides in the Pig Uterus (1990)

The acute effects of oestradiol-17 beta on the expression of the oestrogen receptor (ER) and insulin-like growth factor I (IGF-I) in the endometrium of ovariectomized pigs were examined. The steroid receptor level was assayed by hormone binding techniques and specific mRNAs analyzed by solution hybridization using 35S-labelled RNA probes complementary to the ligand-binding domain of the ER receptor gene and a 160 bp PanI-Pvul fragment of the IGF-I gene. One hour after a single injection of oestradiol (1 micrograms/kg BW), the nuclear oestrogen receptor (ERn) mean level was increased 3-fold whereas the ER mRNA content had not changed significantly. After 3 hours the ERn mean concentration was still high; the mean ER mRNA level had decreased by 15% and the mean IGF-I mRNA had increased 3-fold above that in the samples collected prior to treatment from these ovariectomized animals. Six hours after the injection the ERn content had returned to the basal level and stayed there during the following six hours. The ER mRNA concentration continued to decline, reached its lowest value after six hours and had increased slightly by twelve hours. The IGF-I mRNA level increased steadily during the course of the experiment. At twelve hours after the injection it had increased 3-fold. From these data we conclude that in the pig uterus oestradiol down-regulates its own receptor and acts as a potent stimulator of endometrial growth by inducing IGF-I expression.
Shrimp (Pandalopsis dispar) waste hydrolysate as a source of novel β–secretase inhibitors (2016)

In this study, purified peptides from shrimp waste hydrolysates (SWHs) were examined for their inhibitory effects against β–secretase. During consecutive purification using a Sephadex G–25 column chromatography and high performance liquid chromatography on a C18 column, a potent β–secretase inhibitory peptide Asp–Val–Leu–Phe–His (629 Da) was isolated and identified from SWH24 by Q–TOF MS/MS and the IC50 value was determined to be 92.70 μM. The β–secretase inhibition patterns of the purified peptides were found to be competitive. Among synthesized β–secretase inhibitory peptides, Leu–Phe–His had higher β–secretase inhibitory activity than the others. The result of this study suggests that the β–secretase inhibitory peptide derived from SWH24 could be potential candidates to develop nutraceuticals and pharmaceuticals.
Coherent transmission using an external waveguide Bragg reflector laser with direct frequency modulation (1987)

Single-frequency l.5μm semiconductor lasers, formed by butt-coupling of a regular Fabry—Perot laser to an external waveguide Bragg reflector, are shown to have very uniform frequency modulation characteristics under direct current modulation. The laser's frequency modulation characteristics, together with its narrow linewidth (̃ 1 MHz), make coherent transmission possible without external modulators. The laser performance was evaluated in a 417Mbit/s, 102 km, frequency-shift-keying coherent transmission experiment.
Electronic structure from semiclassical dimensional expansions: symmetry breaking and bound states of the hydride ion (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structure from semiclassical dimensional expansions: symmetry breaking and bound states of the hydride ionD. J. Doren and D. R. HerschbachCite this: J. Phys. Chem. 1988, 92, 7, 1816–1821Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/j100318a025https://doi.org/10.1021/j100318a025research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Thickness measurements of thin anodic oxides on GaAs using atomic force microscopy, profilometry, and secondary ion mass spectrometry (1996)

Techniques to determine the thickness of thin (30–200 Å) anodic oxide films on p-GaAs (100) are reported. The layers were grown potentiostatically in 0.3 M NH4H2PO4 (pH 4.4) solution. By lithographic techniques, several series of squares were etched into the oxide and the step height was measured using both atomic force microscopy (AFM) and a stylus surface profiler (Dektak). Secondary ion mass spectrometry (SIMS) profiles of samples prior to and after the photolithographic treatment show that neither the thickness nor composition of the layers are affected by the treatment. The thickness values obtained in the investigated range show standard deviations better than ±9 Å (AFM) and ±22 Å (Dektak) and correlate well in a linear relation to SIMS sputter times to the interface.
Structural Characterization of an Integral Membrane Protein in Its Natural Lipid Environment by Oxidative Methionine Labeling and Mass Spectrometry (2008)

Membrane proteins represent formidable challenges for many analytical techniques. Studies on these systems are often carried out after surfactant solubilization. Unfortunately, such a non-natural protein environment can affect conformation and stability, and it offers only partial protection against aggregation. This work employs bacteriorhodopsin (BR) as a model system for in situ structural studies on a membrane protein in its natural lipid bilayer. BR-containing purple membrane suspensions were exposed to hydroxyl radicals, generated by nanosecond laser photolysis of dilute aqueous H(2)O(2). The experiments rely on the premise that oxidative labeling occurs mainly at solvent-exposed side chains, whereas sites that are sterically protected will react to a much lesser extent. Following .OH exposure, the protein was analyzed by tryptic peptide mapping and electrospray tandem mass spectrometry. Oxidative labeling of BR was found to occur only at its nine Met residues. This is in contrast to the behavior of previously studied water-soluble proteins, which generally undergo modifications at many different types of residues. In those earlier experiments the high reactivity of Met has hampered its use as a structural probe. In contrast, the Met oxidation pattern observed here is in excellent agreement with the native BR structure. Extensive labeling is seen for Met32, 68, and 163, all of which are located in solvent-exposed loops. The remaining six Met residues are deeply buried and show severalfold less oxidation. Our results demonstrate the usefulness of Met oxidative labeling for structural studies on membrane proteins, especially when considering that many of these species are methionine-rich. The introduction of additional Met residues as conformational probes, as well as in vivo structural investigations, represents exciting future extensions of the methodology described here.
Urgent Cesarean Delivery for Fetal Bradycardia (2009)

II.
Hip arthroscopy in staging avascular necrosis of the femoral head. (2000)

The purposes of this study were to evaluate how accurately current imaging modalities predict the quality of the articular surface in avascular necrosis (AVN) of the femoral head and to provide arthroscopic correlation to current staging modalities. An arthroscopic classification system, derived from the work of Marcus et al, was used to prospectively stage the articular surface in 23 hips with AVN using plain radiographs, magnetic resonance imaging (MRI), and arthroscopy. There was little correlation between all three diagnostic modalities. These findings were not statistically significant. Patients with stage IV disease had the widest variation in the appearance of the articular surface. This study shows poor correlation in the staging of AVN using current imaging techniques. Magnetic resonance imaging has been shown to be inadequate at assessing the articular cartilage. Therefore, either arthroscopy or direct visualization is required for accurate evaluation and staging, especially in stage IV disease.
Thermodynamic, Tribological and Chemical Interdiffusion Study of Ultra-Hard Ceramic AlMgB14 in the Machining of Aerospace Alloys (2003)

There has been a growing concern about the reactivity at the tool/work-piece interface during machining, leading to lower tool life. The problem is more severe especially in the case of aerospace alloys such as Ti-6Al-4V and stainless steels. Recently, a new ultra hard ceramic material, AlMgB14, was reported with properties that show considerable promise as a cutting tool material for machining titanium alloys [1]. This paper investigates the chemical wear behavior of AlMgB14, in the machining of aerospace alloys. The mechanical properties of AlMgB14 are compared with leading cutting tool materials (WC-Co, Al2O3SiCw-TiC and Al2O3-TiC), which are used extensively in machining titanium and ferrous alloys. Materials characterization of candidate tool materials shows that AlMgB14 exhibits superior hardness, fracture toughness and abrasive wear resistance as compared to the other cutting tool materials. We also report on a study of chemical reactivity of tool materials (AlMgB14 and WC-6%Co) in machining various alloys such as Ti-6Al-4V and Fe-18Ni-8Cr. The chemical reactivity was investigated using diffusion tests conducted in vacuum at 1000°C for 120 hrs. Transverse sections of couples were characterized using electron probe micro analysis (EPMA), to determine the extent of diffusion zones. The results show that AlMgB14 shows considerably less reactivity with titanium alloys when compared with cemented carbide cutting tools. It was also observed that the boride reacts significantly with the iron based Fe-18Ni-8Cr alloy. The paper also reports on the evaluation of the free energy of formation of AlMgB14 using the thermochemical software program FactSage™.
The qualified presumption of safety assessment and its role in EFSA risk evaluations: 15 years past (2018)

ABSTRACT Microorganisms are intentionally added at different stages of the food and feed chain (food or feed additive, novel food or plant protection product) and are subjected to regulation and safety assessment by the European Food Safety Authority. Safety evaluation is based on application dossiers for market authorisation to the European Commission. The qualified presumption of safety (QPS) concept was developed in 20032 to provide a harmonised generic safety pre-appraisal of the above microorganisms. Unambiguously defined biological taxonomic units (TUs) are assessed for their body of knowledge, their safety and their end use. Identified safety concerns for a certain TU can be, where reasonable in number and not universally present, reflected as ‘qualifications.’ Strains belonging to TUs having QPS status may benefit of a fast track evaluation. The lowest TU for which the QPS status is granted is the species level for bacteria and yeasts and the family for viruses. The QPS concept is also applicable to genetically modified microorganisms used for production purposes. Based on the current body of knowledge and/or the ambiguous taxonomic position, some TUs, such as filamentous fungi, bacteriophages, Enterococcus faecium, Escherichia coli, Streptomyces spp. and Oomycetes, are not considered liable for QPS status.
A Spectrum-Efficient Multicarrier CDMA Array-Receiver with Diversity-Based Enhanced Time and Frequency Synchronization (2007)

This paper proposes a spectrum-efficient spatio-temporal array-receiver for multi-carrier CDMA systems named MC-STAR. First, we derive a new post-correlation model for MC-CDMA that characterizes the structure of the channel in space, time and frequency. Based on this model, we introduce a new multi-carrier array-receiver with rapid and accurate joint synchronization in time and frequency. There, we exploit jointly the spatial, temporal and frequency diversities as well as the intrinsic inter-carrier correlation (termed hereafter frequency gain) to improve the channel identification and the synchronization operations. In addition, based on a new link/system-level performance analysis, with a band-limited chip waveform assumption, we provide a comparative performance study of MC-STAR over two multi-carrier CDMA air-interface configurations, namely MT-CDMA and MC-DS-CDMA, in the most realistic operating conditions. Link/system-level results confirm the advantages of MT-CDMA in increasing throughput and bandwidth efficiency. The current trend is to design radio air-interfaces with flat fading subcarriers. In contrast, with MC-STAR we show that the positive effects of multipath diversity and frequency gain over large strongly-overlapping subcarriers is more significant than the negative effects of multipath and multi-carrier interference.
PROPENSITY OF COTTON VARIETIES TO NEPPINESS (1990)

ABSTRACT Imperfections in lint cotton, particularly neps and seed-coat fragments, reduce processing efficiency in the textile mill and detract from appearance in yam and fabric. This study identified fiber properties and varieties which are consistently associated with low nep and seed-coat fragment levels in ginned lint, yam, and fabric. Growth conditions and maturity of the cottons were considered; the level of imperfections were measured in both dyed and undyed fabric. Correlations were determined and definite trends established between many of the variables. The information obtained will aid breeders in selecting for further development those cottons which have a low potential for imperfection formation during processing.
Production of intense deuteron beams (1976)

Results are reported on the production of 400-keV 50-nsec-duration 1.3-kA deuteron beams using a reflex triode.
Syndrome de Bouveret traité par lithotritie mécanique (2011)

Le syndrome de Bouveret, défini par l’enclavement d’un calcul dans le bulbe duodénal après formation d’une fistule cholécystoduodénale, est une complication rare de la lithiase biliaire. Le traitement endoscopique peut être efficace, évitant ainsi une chirurgie dont les complications et la mortalité restent élevées. Nous rapportons une observation de syndrome de Bouveret traité par lithotritie mécanique.
REACTIONS OF AMINES. IX. THE REARRANGEMENT OF N-t-BUTYL-N-CHLOROAMIDES<sup>1-2</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTREACTIONS OF AMINES. IX. THE REARRANGEMENT OF N-t-BUTYL-N-CHLOROAMIDES1-2Henry E. Baumgarten, Robert L. Zey, and Uldis KrollsCite this: J. Am. Chem. Soc. 1961, 83, 21, 4469–4470Publication Date (Print):November 1, 1961Publication History Published online1 May 2002Published inissue 1 November 1961https://pubs.acs.org/doi/10.1021/ja01482a041https://doi.org/10.1021/ja01482a041research-articleACS PublicationsRequest reuse permissionsArticle Views214Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simulation of x-ray absorption near edge spectra of electronically excited ruthenium tris-2,2′-bipyridine (2004)

The L(3) edge x-ray absorption near edge spectrum (XANES) of the ground electronic state and the metal to ligand charge transfer state of ruthenium tris-2,2(')-bipyridine is calculated. The final valence states and energies in the presence of the photoelectron and core hole, and the corresponding transition intensities are computed using time dependent density functional theory with the Becke three-parameter density functional with the Lee-Yang-Parr correlation functional. Calculations show a valence shift of the primary XANES peak and the appearance of the new XANES transition to the hole created by the optical excitation, in agreement with experiment [M. Saes, C. Bressler, R. Abela, D. Grolimund, S. L. Johnson, P. A. Heimann, and M. Chergui, Phys. Rev. Lett. 90, 047403 (2003)].
Tapasin Enhances Peptide-Induced Expression of H2-M3 Molecules, but Is Not Required for the Retention of Open Conformers (2001)

H2-M3 is a class Ib MHC molecule that binds a highly restricted pool of peptides, resulting in its intracellular retention under normal conditions. However, addition of exogenous M3 ligands induces its escape from the endoplasmic reticulum (ER) and, ultimately, its expression at the cell surface. These features of M3 make it a powerful and novel model system to study the potentially interrelated functions of the ER-resident class I chaperone tapasin. The functions ascribed to tapasin include: 1) ER retention of peptide-empty class I molecules, 2) TAP stabilization resulting in increased peptide transport, 3) direct facilitation of peptide binding by class I, and 4) peptide editing. We report in this study that M3 is associated with the peptide-loading complex and that incubation of live cells with M3 ligands dramatically decreased this association. Furthermore, high levels of open conformers of M3 were efficiently retained intracellularly in tapasin-deficient cells, and addition of exogenous M3 ligands resulted in substantial surface induction that was enhanced by coexpression of either membrane-bound or soluble tapasin. Thus, in the case of M3, tapasin directly facilitates intracellular peptide binding, but is not required for intracellular retention of open conformers. As an alternative approach to define unique aspects of M3 biosynthesis, M3 was expressed in human cell lines that lack an M3 ortholog, but support expression of murine class Ia molecules. Unexpectedly, peptide-induced surface expression of M3 was observed in only one of two cell lines. These results demonstrate that M3 expression is dependent on a unique factor compared with class Ia molecules.
A Systems Approach to Analysis of Molecular Complexity in Breast Cancer (2009)

In this issue of Clinical Cancer Research, Andre et al. apply high-resolution arrays to elucidate copy number anomalies in breast cancer. They identify distinct copy number anomaly patterns in different breast cancer subtypes that implicate a number of genes as potential therapeutic targets and as potential markers of therapy responsiveness.