gebhart/patrepeval huggingface dataset:
Algebra of stereogenic pairing equilibria. 3. Chiral discrimination (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlgebra of stereogenic pairing equilibria. 3. Chiral discriminationRemi ChauvinCite this: J. Phys. Chem. 1992, 96, 11, 4706–4711Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/j100190a103https://doi.org/10.1021/j100190a103research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Evidence for “loose spins” in epitaxial Al/Fe/Al (1997)

Polarization-dependent Fe K-edge x-ray absorption fine structure measurements of an Al/Fe/Al(001) trilayer reveal a small tetragonal distortion of the Fe sites with c=2.863 Å (normal to the film plane) and a=2.874 Å (in the film plane). This tetragonal distortion is consistent with the formation of Fe1−xAlx alloys in the vicinity of the roughened Fe–Al trilayer interfaces, and agrees with grazing incidence x-ray reflectivity and magnetometry measurements of the trilayer. The deduced alloyed/roughened interfacial regions are the likely source of Fe “loose spins” as recently suggested by Slonczewki’s biquadratic coupling model for the epitaxial Fe/Al/Fe system.
Etching of Tantalum in Fluorine‐Containing High Density Plasmas (1996)

Dry etching of tantalum in fluorine‐containing high density plasmas has been studied. Tantalum etching as a function of gas composition of mixture and mixture, inductive power, bias power, and pressure has been examined using the response surface method. The etched Ta surface was also characterized by electron spectroscopy for chemical analysis to understand the etching mechanism. Tantalum was found to be etched faster in the discharge because of the abundance of fluorine‐containing active species and the absence of fluorocarbon deposition on the surface. For both and mixtures, the etch rate was found to decrease with increasing pressure. The effects of , and on Ta etching were found to be interactive. The dependence of Ta etching on the gas composition, inductive power, bias power, and pressure is discussed in light of the existing knowledge of plasma etching.
Two New β-Carboline Alkaloids from<i>Hedyotis capitellata</i>var.<i>mollis</i> (1999)

Two new beta-carboline alkaloids, hedyocapitelline and hedyocapitine, were isolated from Hedyotis capitellata var. mollis (Rubiaceae). Their structures were elucidated by spectroscopic data (1)H- and (13)C-NMR, MS, IR, UV).
ChemInform Abstract: NEUE METHODE ZUR DARSTELLUNG VON ALPHA,BETA‐UNGESAETTIGTEN BETA‐(THIENYL‐(2))‐SUBSTITUIERTEN METHYLKETONEN (1974)

Abstract Die Reaktion der Thienylhydroxypropionsäuren (II) mit Acetanhydrid in Gegenwart katalytischer Mengen ZnCl 2 liefert nicht die Cyclopentadienothiophene (I), sondern über die gemischten Anhydride (III) überwiegend die Thienylbutenone (IV),′ Daneben bilden sich l‐Phenyl‐2‐[thienyl‐(2)]‐alkene‐(1) und in einem Falle [aus (IIb)] 2‐Phenyl‐3‐[thienyl‐(2)]‐indenon‐(1).
Reversible Inactivation of Human Dipeptidyl Peptidases 8 and 9 by Oxidation (2008)

Hydrogen peroxide (H 2 O 2 ) can act as an intracellular messenger by oxidizing sulfhydryl groups in cysteines that can be oxidized at neutral pH. The oxidizing agents H 2 O 2 and pyrroloquinoline quinone and the large thiol reagents N-ethylmaleimide and 4-(hydroxymercuri) benzoate each inhibited dipeptidyl peptidase (DP) activity in the intracellular DPIV-related proteins DP8 and DP9 at pH 7.5. In contrast, these treatments did not alter activity in DPIV and fibroblast activation protein. Peptidase inhibition was completely reversed by 2-mercaptoethanol or reduced glutathione. Alkylation of DP8 by the small thiol reagent iodoacetamide prevented inhibition by H 2 O 2, N-ethylmaleimide or pyrroloquinoline quinone. Two cysteines were reactive per peptidase monomer. We exploited these properties to highly purify DP8 by thiol affinity chromatography. Homology modelling of DP8 and DP9 was consistent with the proposal that the mechanism involves decreased protein flexibility caused by intramolecular disulfide bonding. These novel data show that DP8 and DP9 are reversibly inactivated by oxidants at neutral pH and suggest that DP8 and DP9 are H 2 O 2 sensing proteins.
Phosphorylation of histones is stimulated by phorbol esters in quiescent Reuber H35 hepatoma cells. (1986)

Histones isolated from Reuber H35 rat hepatoma cells treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined for possible alterations in phosphorylation. Incorporation of 32P orthophosphate into individual acid-extracted histones was monitored by autoradiography and scintillation counting of polyacrylamide gels or by reverse-phase high performance liquid chromatography. Treatment of quiescent H35 cells (arrested by serum starvation) with submicromolar doses of TPA resulted in a rapid and specific increase in phosphorylation of histones H2B and H1(0). Smaller increases in phosphorylation were observed for H4. No significant change in phosphorylation of the major H1 histones or H2A were observed after 1 h of treatment. The phosphorylation was TPA dose-dependent, with a maximum increase of approximately 14-fold for H2B, 11-fold for H1(0), and 2-fold for H4 achieved at 0.8 M TPA. The nonpromoting parent compound phorbol did not induce any of these changes. Furthermore, the mitogenic hormone insulin did not cause a similar pattern of histone phosphorylation, suggesting that the effect observed was not due to a general mitogenic response in the H35 hepatoma cells. Addition of 8-Br-cAMP also failed to reproduce the effect of TPA on histone phosphorylation, suggesting that cAMP-dependent protein kinases are not likely to be involved in mediating this response to TPA.
Drug Release From Emulsions Stabilized by Colloidal Macrocrystalline Cellulose (1989)

ABSTRACT Drug release from water-in oil-in water (w/o/w)multiple emulsions stabilized with colloidal microcrystal-line cellulose and various surface-active agents has been studied in vitro. Lidocaine hydrochloride and lidocaine base were used as model drugs for these studies. Drug concentrations were measured by HPLC, and effective diffusion coefficients were determined.
PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier (2017)

Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of monogenic genodermatoses that encompasses non-syndromic disorders of keratinization. The pathophysiology of ARCI has been linked to a disturbance in epidermal lipid metabolism that impaired the stratum corneum function, leading to permeability barrier defects. Functional characterization of some genes involved in ARCI contributed to the identification of molecular actors involved in epidermal lipid synthesis, transport or processing. Recently, PNPLA1 has been identified as a gene causing ARCI. While other members of PNPLA family are key elements in lipid metabolism, the function of PNPLA1 remained unclear. We identified 5 novel PNPLA1 mutations in ARCI patients, mainly localized in the putative active enzymatic domain of PNPLA1. To investigate Pnpla1 biological role, we analysed Pnpla1-deficient mice. KO mice died soon after birth from severe epidermal permeability defects. Pnpla1-deficient skin presented an important impairment in the composition and organization of the epidermal lipids. Quantification of epidermal ceramide species highlighted a blockade in the production of ω-O-acylceramides with a concomitant accumulation of their precursors in the KO. The virtually loss of ω-O-acylceramides in the stratum corneum was linked to a defective lipid coverage of the resistant pericellular shell encapsulating corneocytes, the so-called cornified envelope, and most probably disorganized the extracellular lipid matrix. Finally, these defects in ω-O-acylceramides synthesis and cornified envelope formation were also evidenced in the stratum corneum from PNPLA1-mutated patients. Overall, our data support that PNPLA1/Pnpla1 is a key player in the formation of ω-O-acylceramide, a crucial process for the epidermal permeability barrier function.
Manganese-Hydrogen Bond Distance in HMn(CO)<sub>5</sub> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTManganese-Hydrogen Bond Distance in HMn(CO)5Thomas C. Farrar, W. Ryan Sr., Alan Davison, and J. W. FallerCite this: J. Am. Chem. Soc. 1966, 88, 1, 184–185Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/ja00953a046https://doi.org/10.1021/ja00953a046research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characteristics of Iron Phosphate and Its Catalytic Activity for Oxidative Dehydrogenation of Isobutyric Acid (1996)

Abstract In the absence of oxygen, P/Fe = 1.2 catalyst samples are reduced by hydrogen or isobutyric acid to form Fe2P2O7 via Fe3(P2O7)2, while the P/Fe = 1.0 samples are reduced directly to Fe2P2O7; without passing through Fe3(P2O7)2. Fe2P2O7 is oxidized by air to an unknown compound (Y-phase), but not to Fe3(P2O7)2 nor FePO4. The Y-phase is reduced to Fe2P2O7. During the use in the oxidative dehydrogenation of isobutyric acid, freshly calcined catalysts are reduced to Fe3(P2O7)2, while the Fe2P2O7 catalysts are oxidized to Y-phase, though the rates are very slow. The catalytic activity and selectivity are scarcely affected by variation in the structure of the iron phosphate catalyst and in the oxidation states of iron ions. The P/Fe and Fe2+/(Fe2++Fe3+) ratios on the surface, which were measured from cooled catalyst samples, are almost the same as those in the bulk.
Organometallic Chemistry (2002)

Organometallic chemistry is an interdisciplinary science which continues to grow at a rapid pace. Although there is continued interest in synthetic and structural studies the last decade has seen a growing interest in the potential of organometallic chemistry to provide answers to problems in catalysis synthetic organic chemistry and also in the development of new materials. This Specialist Periodical Report aims to reflect these current interests reviewing progress in theoretical organometallic chemistry, main group chemistry, the lanthanides and all aspects of transition metal chemistry. Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Mechanochemical and Conventional Synthesis of Copper(II) Coordination Polymers Bearing Arylhydrazone of Acetoacetanilide and Their Catalytic Activity in Conversion of Acetone to Acetic Acid (2020)

Abstract Copper(II) coordination polymers, [Cu( μ 2 ‐HL)] n ⋅n(CH 3 ) 2 C=O ( 1 ), [Cu( μ 1 ‐HL)(CH 3 OH)] n ( 2 ) and [Cu( μ 1 ‐HL)(H 2 O)] n ( 3 ) were isolated by recrystallization (in acetone, methanol and dimethylformamide, respectively) of an intermediate produced by a solid state ball milling reaction of CuCl 2 ⋅2H 2 O with 2‐(2‐(1,3‐dioxo‐1‐(phenylamino)butan‐2‐ylidene)hydrazinyl)benzoic acid (H 3 L). Reaction under conventional fully solution‐based conditions of CuCl 2 ⋅2H 2 O with H 3 L in acetone and dimethylformamide leads to 3 , and in methanol to the known monomeric compound [Cu(HL 1 )(H 2 O)(CH 3 OH)] ( 4 ). All the coordination polymers 1 − 3 act as homogenous catalysts for the peroxidative (H 2 O 2 ) oxidation of acetone to acetic acid with yields up to 50% and at room temperature.
CHAPTER XXIII (2010)

It was supposed, after the debate, of which the substance has been just given, that there would have been no further discussion of the subject till the next year: but Sir William Dolben became more and more affected by those considerations which he had offered to the house on the ninth of May. The trade, he found, was still to go on. The horrors of the transportation, or Middle Passage, as it was called, which he conceived to be the worst in the long catalogue of evils belonging to the system, would of course accompany it. The partial discussion of these, he believed, would be no infringement of the late resolution of the house. He was desirous, therefore, of doing something in the course of the present session, by which the miseries of the trade might be diminished as much as possible, while it lasted, or till the legislature could take up the whole of the question. This desire he mentioned to several of his friends; and as these approved of his design, he made it known on the twenty-first of May in the House of Commons.
Histology- and gender-related associations of ERCC1, RRM1, and TS biomarkers in 1,802 patients with NSCLC: Implications for therapy. (2010)

7513 Background: Histology-based decision making for non-small cell lung cancer (NSCLC) has recently been advocated. We hypothesized histology- and gender-related associations for purported chemotherapy predictive biomarkers: ERCC1 (platinum), RRM1 (gemcitabine), thymidylate synthase or TS (pemetrexed). We report analysis of the Response Genetics (RGI) database and implications for therapy. Methods: RNA from microdissected formalin-fixed paraffin-embedded tumors was analyzed as previously described, reported as the ratio of gene expression to β-actin. For reference, median ERCC1 levels <1.7, RRM1 <0.97 and TS <2.33 are reported to correlate with improved response. Results: Specimens from 1,802 individual NSCLC patients were analyzed for 1 or more biomarkers. For each biomarker, gene expression is higher in SCCA compared with AC (<0.001*), including RRM1, a reported biomarker for gemcitabine. There is no association of gene expression with age or stage. Gene expression is higher in males vs females: ERCC1: 2.51 vs 2.22 p=0.005; RRM1: 1.41 vs 1.24 p=0.004; TS: 3.23 vs 2.83, p<0.001*. However, SCCA is more frequent in males vs females (30%/19%, p<0.001, Fischer exact test). When AC and SCCA are assessed separately, statistical significance between gene expression and gender is lost (in SCCA: ERCC1 p=0.14; RRM1 p=0.26; TS p=0.11). Conclusions: 1) This analysis represents the largest dataset of these biomarkers yet reported. 2) While significant histology-related associations for ERCC1, RRM1 and TS are seen, marked heterogeneity exists in individual patient expression levels. 3) Gender-related associations suggesting enhanced chemotherapy sensitivity in females are partly histology-related. 4) Biomarker assessment in individual NSCLC patients may optimize histology-based decision making. Biomarker NSCLC-Total N = 1,802 NSCLC-Squamous(SCCA) N = 392 NSCLC-Adenoca(AC) N = 920 SCCA vs. AC P value ERCC1 N 1,593 371 786 <0.001* Median 2.14 2.6 1.93 Range 0.04-24.79 0.27-14.34 0.04-24.79 RRM1 N 925 189 501 <0.001* Median 1.3 2.84 1.09 Range 0.25-33.19 0.56-33.19 0.25-10.93 TS N 1,014 264 500 <0.001* Median 2.92 4.31 2.5 Range 0.14-60.58 0.14-59.16 0.39-30.33 * Mann-Whitney test. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Response Genetics Amgen, AstraZeneca, Biodesix, Boehringer Ingelheim, Bristol-Myers Squibb/Imclone, Genentech, GlaxoSmithKline, Lilly, Merck, Novartis, Pfizer, Response Genetics, sanofi-aventis Response Genetics Response Genetics Abbott Laboratories, Bristol-Myers Squibb/ImClone, Genentech, Lilly, Merck, Novartis, Pfizer
Pulse contour analysis after normothermic cardiopulmonary bypass in cardiac surgery patients (2005)

We observed an excellent correlation of COPiCCOtherm and COPACtherm measurement prior to CPB. Pulse contour analysis did not yield reliable results with acceptable accuracy and limits of agreement under difficult conditions after weaning from CPB in cardiac surgical patients. The pulse contour analysis thus should be re-calibrated as soon as possible, to prevent false therapeutic consequences.
Regulation of<i>manX</i>(<i>ptsL</i>) and<i>manY</i>(<i>pel</i>) genes required for mannose transport and penetration of Î»DNA in<i>Escherichia coli</i>K12 (1987)

The manXYZ (ptsL, pel/ptsM) locus consists of 3 genes involved in mannose transport in Escherichia coli K12. In addition, the manY gene product is required for penetration of λDNA into the cell. We have previously constructed a series of lacZ gene fusions to manYZ. In this paper we describe the molecular cloning and regulatory properties of these fusions. A λ transducing phage was isolated that carried both the manX gene and the manYZ-lacZ gene fusion. The manX gene together with the fusion was subcloned into the fusion cloning vector pMLB524. Analysis of these subclones showed that lacZ was fused to manY. The manX and manY genes appeared to be in the same operon, manX being the promoter-proximal gene.
Correlation of Serum Total IgE, Eosinophil Granule Cationic Proteins, Sensitized Allergens and Family Aggregation in Atopic Dermatitis Patients with or without Rhinitis (2004)

Atopic dermatitis (AD) is a complex disease with both a genetic background and environmental interactions. Although multiple linkage-analyses about AD have been studied, there have been only a few family aggregation tests of AD or perennial allergic rhinitis (AR) to date. The association of allergen-specific IgE in AD and atopic dermatitis with allergic perennial rhinitis (ADR) have also been seldom discussed. The purpose of this study was to evaluate family aggregation and assess allergen-specific IgE in patients with AD and ADR. We also planned to investigate the effect of family history of AD on the prevalence of allergen-specific antibodies. The serum levels of IgE, eosinophil cationic protein (ECP) and major basic protein (MBP) were measured and compared in patients with AD and those with ADR. Proportional analysis compared allergen-specific IgE between AD and ADR. The family aggregation was conducted to estimate the odds ratio for various atopic diseases in different family members. Total IgE and allergen-specific antibodies in serum were compared between those patients who had AD with AR and those without. The result revealed that allergic rhinitis is the most common concomitant atopic disease associated with AD. The ADR group was more likely to have serum mite-, cockroach-, and feather-specific IgE. The positive rates for wheat, peanut and soybean were higher in those AD without rhinitis. In the family aggregation of AD, the odds ratio for siblings was higher than for parents, the ratios for brother and sister were 9.91 and 8.75, respectively. However, the odds ratio for parents of ADR was higher than siblings; the ratios for father and mother of ADR were 8.22 and 2.94, respectively. AD patients with family histories of AD were more likely to have mite-, soybean-, and peanut-specific antibodies in their serum. We concluded that aeroallergens are the most important allergens aggravating atopic diseases in Taiwan. Food plays an important role in the pathogenesis of AD. Measurement of serum total IgE combined with the MAST-CLA test could be helpful in the diagnosis of atopic diseases. The differential aggregation tendency for AD and ADR implicated the complexity of the gene-environment interaction in these atopic diseases.
Prospects of highly efficient AlGaInP based surface emitting type ring-LED for 50 and 156 Mb/s POF data link systems (1998)

The detail design and performance of the surface emitting type visible light emitting diode (LED) is described for using in the plastic optical fiber (POF)-based data links. The diode showed brightness as high as 3.5 mW@100 mA (dc) and also exhibited the beam divergence angle as low as 10/spl deg/ with using of well designed plastic lens. The using of LED with plastic lens helps to attain also the coupling efficiency over 70% with POF. The temperature rise of the ring LED under operation is also estimated to be 9 and 6/spl deg/C less than the conventional diode at 50 and 35 mA bias currents, respectively. Transmission experiments reveal that the diode is suitable for 50 and 156 Mb/s 100 m POF-based data links.
Capacity and properties of slave mode hidden channel coding (2003)

A novel approach for using bit-rate reduction together with the hidden channel technique to accomplish compatible multichannel audio in the European high-definition television (HDTV) system is presented. In this system, a compatible stereo audio signal is used as a carrier for hidden multichannel information. A slave mode decoding is introduced, resulting in a low-complexity implementation of the decoder. The capacity and properties of slave mode hidden channel coding are reported. The inherent bit error rate is discussed. Examples of the dynamic data transmission rate and the related bit error rate measured in the implemented real-time system are provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>