gebhart/patrepeval huggingface dataset:
Report on isoelectric focusing trial of erythropoietin profiling in two cancer patients during chemotherapy and darbepoetin treatment. (2011)

The level of erythropoietin, main regulator of erythropoiesis, is affected by hypoxia, anaemia, application of recombinant erythropoietin, chemotherapy and others. Isoelectric focusing (IEF) combined with double immunobloting is a method that enables distinct analysis of endogenous and recombinant erythropoietin isoforms. Aim of our study was to set up analysis of treatment effects on the pattern of endogenous erythropoietin in anaemic breast cancer patient. Urine and blood samples were collected during and after termination of the treatment and analysed by isoelectric focusing. Endogenous erythropoietin was found lower, but still detectable during darbepoetin treatment. Normal shift of erythropoietin isoforms between serum vs. urine, ordinary seen in healthy volunteers, was not observed indicating kidney damage. The patient was suffering from heavy proteinuria and had low Glomerular filtration rate indicating acute renal failure, probably caused by clinical status or cisplatin chemotherapy. IEF has not yet been used for follow up of erythropoietin profile in cancer patients. It enables to monitor the effects of treatment on the level of endogenous erythropoietin and indirectly indicates kidney function.
Spin Crossover in a Catenane Supramolecular System (1995)

The compound [Fe(tvp)(2)(NCS)(2)] . CH(3)OH, where tvp is 1,2-di-(4-pyridyl)-ethylene, has been synthesized and characterized by x-ray single-crystal diffraction. It consists of two perpendicular, two-dimensional networks organized in parallel stacks of sheets made up of edge-shared [Fe(II)](4) rhombuses. The fully interlocked networks define large square channels in the [001] direction. Variable-temperature magnetic susceptibility measurements and Mössbauer studies reveal that this compound shows low-spin to high-spin crossover behavior in the temperature range from 100 to 250 kelvin. The combined structural and magnetic characterization of this kind of compound is fundamental for the interpretation of the mechanism leading to the spin crossover, which is important in the development of electronic devices such as molecular switches.
ChemInform Abstract: Synthesis and Biological Evaluation of N‐(1‐Aziridino)‐6‐ fluoroquinolone‐3‐carboxylic Acids. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Catalytic Oxidation of Formic Acid in Water. Intraparticle Diffusion in Liquid-Filled Pores (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Oxidation of Formic Acid in Water. Intraparticle Diffusion in Liquid-Filled PoresG. Baldi, S. Goto, C.-K. Chow, and J. M. SmithCite this: Ind. Eng. Chem. Process Des. Dev. 1974, 13, 4, 447–452Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://doi.org/10.1021/i260052a026RIGHTS & PERMISSIONSArticle Views305Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (628 KB) Get e-Alerts
Interaction of the Restriction Endonuclease EcoRV with the Deoxyguanosine and Deoxycytidine Bases in Its Recognition Sequence (1994)

The interaction of the EcoRV restriction endonuclease with the dG and dC bases in its recognition sequence (GATATC) has been studied using base analogues. These modified dG and dC bases each have a single potential protein contact removed. The analogues have been incorporated into the self-complementary dodecamer d(pGACGATATCGTC) at the appropriate positions (underlined). Many of the analogues caused no change in the Tm of the duplex or else lowered the Tm by a small amount such that a duplex was still formed at temperatures suitable for enzyme assay. However, the dG analogue 2-aminopurine-1-beta-D-2'-deoxyriboside destabilized the duplex to such an extent that the 12'-mer could not be used for enzyme assays. To overcome this, a longer self-complementary 18'-mer was used with this modified base. The circular dichroism spectra of the modified base containing 12'-mers (and the 18'-mer in the case of 2-aminopurine) were very similar to the parent sequences lacking modified bases. This demonstrates the formation of B-DNA structures in all cases and similar overall conformations. The Km and kcat values for the various modified oligomers have been determined, and these data have been used to assess the roles that functional groups on the dG and dC bases play in the recognition and hydrolysis of GATATC sequences by the endonuclease. The results obtained here have been compared to the crystal structures of the EcoRV complexed with a GATATC sequence, and this has allowed a critical evaluation of the base analogue approach.(ABSTRACT TRUNCATED AT 250 WORDS)
Cytoskeleton inhibitors combined with TRAIL induce apoptosis in HeLa carcinoma cells overexpressing antiapoptotic protein Bcl-2 (2008)

TRAIL (Apo2L), a cytokine from the family of tumor necrosis factors (TNF), causes apoptosis in various types of tumor cells but is not toxic for normal cells. Recombinant TRAIL obtained using an original method stimulates the release of cytochrome c from mitochondria into the cytoplasm and apoptosis in HeLa carcinoma cells. Expression of oncoprotein Bcl-2 in these cells blocks both processes. The microtubule inhibitors taxol, nocodazole, and colcemid, as well as an inhibitor of actin microfilaments cytochalasin D, enhance the action of TRAIL and allow it to overcome protection caused by overexpression of Bcl-2. This effect is not associated with enhancement of early steps of TRAIL-dependent apoptosis leading to activation of caspase-8 and Bid protein. The inactivation of Bcl-2 also does not define the effect of cytoskeleton inhibitors. It is supposed that destruction of cytoskeleton alters the mechanism of the TRAIL- (or TNF)-dependent cytochrome c release from mitochondria by making it resistant to Bcl-2. The combined use of cytoskeleton inhibitors, which are antitumor drugs, with the recombinant TRAIL preparations may be efficient in therapy of tumors resistant to traditional chemotherapy.
Control functionality of DAQ-Middleware (2014)

DAQ-Middleware is a software framework for a network-distributed data acquisition (DAQ) system that is based on the Robot Technology Middleware (RTM). The framework consists of a DAQ-Component, that is implemented as a data transfer module, a data gather module, a data record module, etc., and a DAQ-Operator, that is implemented as a control module of other components. The basic functionalities, that are necessary as a DAQ system, such as transferring data, starting and stopping the system, etc., are already prepared in the framework. But one of control functionalities, i.e., the functionality of changing parameter values on the DAQ-Components, wasn't provided yet. In order to implement the functionality, the framework has to have the communication method to transfer data from the DAQ-Operator to the DAQ-Component, and the new state to realize the functionality because it should be separated from a normal state to acquire data. Then we developed and added the new functionality in the DAQ-Middleware to transfer data from DAQ-Operator to DAQ-Components in the new state. The new DAQ-Middleware framework allows us to implement easily not only functionality of acquiring data but also that of controlling component modules.
Electromagnetic scattering from a spherical polydispersion of coated spheres (1976)

The volume averaged cross sections for extinction, scattering, absorption, and radiation pressure along with the elements of the phase matrix were computed for a spherical polydispersion of water coated carbon particles. The wavelength used was 4910 A. Two cases were considered. For one we held the thickness of the water coating constant over the polydispersion, while the parameter q = r(0)/r, (the ratio of core radius to total radius) was varied. For the subsequent case we held q constant over the polydispersion, while the thickness of the coating varied. The results show that there are large differences in both the intensity and degree of polarization between dry and wet aerosols. Also interference phenomena can occur, which demonstrate that the assignment of an average refractive index to aerosols can be misleading and can lead to erroneous results.
IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-γ-receptor-deficient mice (1995)

Cytokines can be used as adjuvants to enhance and direct protective immune responses induced by vaccines. IL-12, a cytokine that favors the maturation of Th1-type cells and stimulates associated cell-mediated responses was evaluated as immunologic adjuvant for a viral vaccine in a mouse challenge model. When it was administered together with inactivated pseudorabies virus, a herpes simplex virus related alpha-herpesvirus, increased production of IFN-gamma by ex vivo-stimulated splenocytes was observed as well as augmented production of antiviral serum lgG2a. This was associated with increased protection against a lethal challenge infection. Infection of IfN-gamma-neutralizing Ab reduced the increased antiviral resistance in IL-12-treated mice. Also, in mice bearing an inactivated IFN-gamma-receptor gene IL-12 failed to stimulate protection against challenge and the synthesis of antiviral lgG2a. However, in these IFN-gamma-receptor knockout mice, increased antiviral lgG2b levels and enhanced IFN-gamma-secretion, with minimal IL-4 production, by ex vivo-stimulated splenocytes was observed. In wild-type mice administration of recombinant IFN-gamma but not IL-2 mimicked the immune-stimulating activity of IL-12; it is therefore likely that the IL-12 adjuvant activity is largely mediated by physiologic IFN-gamma.
An analytical model of the mechanical properties of the single-crystal macro-fiber composite actuator (2004)

While exhibiting powerful characteristics, monolithic piezoelectric sensors and actuators suffer from many drawbacks due to inherent material properties and implementation issues. As a result of their stiff structure and primary operating principle, monolithic piezoelectric wafers perform poorly in a variety of important engineering applications. Piezoelectric Fiber Composites (PFCs) offer one possible solution to these limitations. Mechanically flexible and functioning on the basis of the d33 effect, these actuators enable and improve many piezoelectric applications. The NASA-Langley Research Center recently developed the Macro-Fiber Composite (MFC) actuator to address several shortcomings in the operational characteristics of competing PFC packages. While the construction of this actuator results in many advantages over comparable PFCs, potential exists for improvement in the design of the MFC. Thus, the single-crystal MFC is proposed. Single-crystal PMN, a specific piezoceramic compound, comprises the piezoceramic fibers of the proposed device, contributing larger piezoelectric coupling, higher bandwidth and higher stiffness to the MFC configuration. Development of this new actuator necessitates extensive characterization of its electromechanical properties. This paper describes the development and computational results of a short-circuit stiffness model that produces the four independent mechanical properties which describe the single-crystal MFC. Modeling results are compared to those of the standard MFC.
Large Scale Biologically Realistic Models of Cortical Microcircuit Dynamics with Application to Novel Statistical Classifiers (Pilot Investigation) (2000)

Abstract : The purpose of this project was to better understand brain-like network dynamics by incorporated biological parameters into large-scale computer simulations using parallel distributed clustering. Milestones included improved single- processor efficiency of 24-fold. On multiprocessor clusters, initial time trials on - networks of 2 to 1000 cells suggests that the total time does not depend as heavily on the product (connection probability) x (N cells)squared, but shows a substantial * linear term. The projected time to run a 1-million cell simulation would be about 5.6 days on a single CPU, or roughly 6 hours on the proposed 30-CPU Beowulf system. Substantial progress was made toward a C++ implementation for subsequent research.
Backbone Dynamics for the Wild Type and a Double H52R/T56W Mutant of the vnd/NK-2 Homeodomain from <i>Drosophila melanogaster</i> (2001)

The (15)N relaxation behavior and heteronuclear Overhauser effect data for the wild type and an H52R/T56W double mutant protein that encompasses the vnd/NK-2 homeodomain from Drosophila melanogaster were used to characterize and describe the protein backbone dynamics. This investigation, which includes a description of a model structure for the H52R/T56W double mutant vnd/NK-2 homeodomain, was carried out for the two proteins in both the free and DNA-bound states. The double residue replacement at positions 52 and 56 within the DNA recognition helix of vnd/NK-2 has been shown to lead to a significant secondary structural modification resulting in an increase in the length of the recognition helix for the unbound protein. These structural changes are accompanied by corresponding changes in the T(1) and T(1)(rho) relaxation times as well as in the heteronuclear Overhauser effect (XNOE) values that show that the structural stability of the protein is enhanced by the two residue replacements. The values of the rotational anisotropy, D(parallel)/D(perpendicular), derived from analysis of the (15)N T(1) and T(1)(rho) relaxation values are small (1.189 for the unbound homeodomain and 1.110 for the bound homeodomain; both analyzed as prolate ellipsoids of revolution). A comparison of the T(2) values of the wild type and double mutant homeodomain reveals the presence of a low-frequency exchange contribution for the wild type analogue. These relaxation studies show that the motional behavior of the protein primarily reflects the tertiary structure and stability of the homeodomain backbone as well as the respective changes induced upon site-directed residue replacement or DNA binding.
Electronic structure of the interface of aluminum nitride with Si(100) (2008)

The band alignment at the interfaces of Si(100) with amorphous (a-) and crystallized (c-) AlN layers was analyzed using internal photoemission and photoconductivity spectroscopy. The bandgap of thin a-AlN layers grown using atomic layer deposition is found to be 5.8±0.1 eV, widening to 6.5±0.2 eV after annealing induced crystallization into the wurtzite phase. Internal photoemission of electrons from the Si valence band to the AlN conduction band was found to exhibit the same energy threshold of 3.2±0.1 eV in amorphous and crystallized AlN. The energy band diagrams of a-AlN/Si(100) and c−AlN/Si(100) interfaces are established.
In Vivo Human Choroidal Thickness Measurements: Evidence for Diurnal Fluctuations (2009)

Signal processing techniques provide choroidal thickness estimates in many, but not all, PCI datasets of axial eye measurements. Based on eyes with identifiable postretinal peaks at more than one time in a day, choroidal thickness varied over the day. Because of the established role of the choroid in retinal function and its possible role in regulating eye growth, further development and refinement of clinical methods to measure its thickness are warranted.
Physicians' responses to diagnostic test guidelines. (1992)

Internists (IM), subspecialty internists (SS), and family practitioners (FP) were surveyed regarding their opinions of ten of the Blue Cross Blue Shield Association/American College of Physicians diagnostic test use guidelines applied to the asymptomatic periodic health exam. The majority of 390 respondents agreed with the guidelines (59% of all responses). There was at least 40% disagreement with seven of ten guidelines. Board certification was associated with agreement. Internists and family practitioners were more likely to agree than subspecialty internists. The number of years in practice had a negative correlation with agreement for five guidelines. HMO physicians tended to agree with guidelines that discouraged test ordering. Results indicate that these guidelines for test use, based on research data and developed cooperatively by physicians, are a starting point for guidelines to testing during the periodic health examination.
RAPID MEASUREMENT OF N<sub>2</sub>+ ROTATIONAL TEMPERATURES IN AURORA (1963)

A description is given of a photoelectric "temperature photometer" which gives a temperature reading from aurora in about one second. It uses two narrowband interference filters to measure the intensity in two parts of the bright N 2 + band at 3914 Å, and a third to allow a background measurement. The reading is presented on a meter and is independent of the auroral intensity over a wide range. Observations of aurora have permitted construction of a temperature profile for the atmosphere from 95 to 170 km, showing a gradient of 6.0° K/km. A lowest temperature of 140 ± 20° K was observed for a period of several minutes. Diffuse surfaces appear from their temperatures to occur anywhere from 100 to 160 km.
ChemInform Abstract: ORGANOMETALLPHOSPHIN‐SUBSTITUIERTE UEBERGANGSMETALL‐KOMPLEXE 11. MITT. ORGANOMETALLPHOSPHIN‐(CYCLOPENTADIENYL)‐DICARBONYL‐ UND ‐(METHYLCYCLOPENTADIENYL)‐DICARBONYL‐MANGAN‐KOMPLEXE (1971)

Abstract Durch Umsetzung der π‐Cyclopentadienylmangantricarbonyle (I) mit den tertiären Phosphinen (II) werden unter CO‐Abspaltung die Komplexe (III) dargestellt.
Experimental Evaluation of a MIMO Adaptive Dual MPC (2015)

Maintaining uniformly satisfactory control performance of an MPC scheme in the face of changing operating conditions is a difficult task. An adaptive MPC scheme that directs the output towards a reference and simultaneously injects a probing signal to get more information about the system for better model identification appears to be ideally suited for achieving this goal. In this work, taking motivation from the dual control problem originally developed by Feldbaum [1960], a MIMO adaptive dual MPC (adaptive DMPC) formulation has been proposed, which does not require external probing signals to improve the model parameter estimates. The objective function of the MPC is modified to include terms that ensure that sufficient excitation is injected into the system while performing the control tasks. The efficacy of the proposed adaptive DMPC formulation is evaluated by conducting experimental studies on the benchmark heater mixer system. The experimental results demonstrate that the proposed formulation is able to inject probing inputs of small magnitude while meeting the desired servo and regulatory control objectives.
Secreted frizzled‐related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis (2014)

Our findings demonstrate that Sfrp5 may ameliorate mouse liver fibrosis through inhibition of Wnt5a/Fz2 signalling.
Analysis of two-dimensional compressible-flow loss characteristics downstream of turbomachine blade rows in terms of basic boundary-layer characteristics (1955)

Report presenting the effect of compressibility on the loss characteristics downstream of two-dimensional turbomachine blade rows. In this particular example, increasing the trailing-edge thickness increased the overall loss coefficients significantly, with an effect of compressibility only at exit flow angles close to axial.
Monitoring Structural Response of a Wooden Light-Frame Industrial Shed Building to Environmental Loads (2005)

Light-frame wooden buildings are highly complex and redundant structural systems that behave as assemblies of folded and interlocked rib-stiffened plate systems. This paper describes structural monitoring experiments on one such structure. A single storey industrial shed building located in Québec City, Canada, was monitored to determine its displacement response to wind and snow loads. Displacements were correlated with real-time estimates of these environmental loads. Observations encompassed deformations of a continuous strip of the wall and roof. Artificial (static) distributed and point loads were also applied to the structure to enhance understanding of how structural components interact. Limited finite element analysis was conducted for the rib stiffened roof system and the overall assembly, with agreement between predicted deformations and those observed under environmental or artificial loads. Measured response under snow loads confirmed theoretical expectations that composite action and load sharing are important mechanisms for light-frame buildings. The general trends for the main wind effects with steady wind direction were set, but simplified pressure coefficients had to be used for this study. A more detailed description of the wind load is needed, which can be obtained with measurements of the pressure distribution on the envelope of the building in full scale, supplemented with a wind-tunnel study. This project proved the feasibility of real-time monitoring and was the precursor for a larger monitoring project currently in progress at the University of New Brunswick.
New Insights into Phospholipase D and Sphingosine Kinase Activation in Arabidopsis (2012)

International audience
The combustion of Hat Creek coaly waste in an atmospheric fluidized bed combustor (1983)

Hat Creek coaly waste, containing 44% ash and 17% moisture, was burnt in an atmospheric fluidized-bed combustor at combustion efficiencies over 97%. Efficiencies up to 99% were achieved when feeding the coaly waste in-bed rather than overbed. The ash from the coaly waste, which produced a "B" type powder according to Geldart's classification, allowed the bed to operate in the bubbling and slugging regimes over fluidizing velocities ranging from 1 to 2.5 m/s. By optimizing carbon burn-out with bed temperatures and coal feed arrangement, a high proportion of the alumina in the clay was removed in an acid recoverable form.
Metal hydride mediated reduction of 1,3-dimethyl-3(methylthio)oxindole (1997)

The metal hydride mediated reduction of 4-carboethoxy-1,3-dimethyl-3-(methylthio)oxindole with lithium aluminum hydride and lithium triethylborohydride was studied. The results show that reduction of the oxindole carbonyl group is competitive with reduction of the pendant ester. The hemi-aminal that results from initial addition of hydride to the oxindole carbonyl may follow a number of reaction pathways, one of which is an unprecedented rearrangement. A mechanism is proposed that accounts for all observed products. Keywords: oxindole, reduction, rearrangement.
Synthesis and properties of ferroelectric liquid crystals with large spontaneous polarizations (1988)

Abstract The synthesis and some properties of optically active materials derived from amino acids will be described. Also we will report the properties of some compositions consisted of the chiral compounds and achiral Sc compounds. They have fast switching times at around room temperature.