gebhart/patrepeval huggingface dataset:
Organisation du colloque:: Editer dans l'Université: Les défis majeurs, technologies & management, recherche, ouverture sur la société (2013)

Organisé à l’occasion du quarantième anniversaire des Editions de l’Université de Bruxelles, un colloque international intitulé Editer dans l’université. Les défis majeurs, technologie & management, recherche, ouverture sur la société aura lieu les 1er et 2 février, à l’Académie royale de Belgique.Après une conférence grand public le vendredi en fin d’après-midi donnée par Paul Magnette, la journée du samedi 2 février sera consacrée à une réflexion sur les enjeux fondamentaux de l’édition scientifique (en sciences humaines comme en sciences et techniques) et sur son avenir qui intéressera tous les acteurs du monde du livre (éditeurs, auteurs, directeurs de collection, libraires, bibliothécaires…). Elle se décline en trois sessions :• Editer dans l’université. Politiques académiques et modèles économiques (rapporteur :Françoise Benhamou, Université Paris XIII) ;• Communiquer la science à l’heure du web 2.0 (rapporteur :Evelyne Broudoux, Conservatoire national des arts et métiers) ;• Publier en français dans un monde globalisé (rapporteurs :Bernard Cerquiglini, Agence universitaire de la Francophonie et Yves Gingras, Université du Québec).
A Novel Moisture-Absorbing Extracellular Polysaccharide from Rhodococcus rhodochrous SM-1. (2002)

An extracellular polysaccharide (EPS) prepared from SM-1, a mucoidal mutant of Rhodococcus rhodochrous ATCC 12674 was found to absorb and retain moisture in both dry and high-temperature environments.The EPS absorbed more than 120% and 17% of its weight in moisture under the conditions of 32% and 11% relative humidity, respectively, representing much higher absorption than that of known moisture absorbents such as silica gel, glycerol, and hyaluronic acid.The SM-1 EPS is an acidic polysaccharide containing D-galactose, D-glucose, L-fucose, and D-glucuronic acid at a molar ratio of 6: 3: 2: 4. In addition, 1.2% (W/W) stearic acid, 2.3% (W/W) palmitic acid, and 10.3% (W/W) pyruvic acid were also contained in the SM-1 EPS.These evidences indicate that the SM-1 EPS is a novel moistureabsorbing biopolymer.
Detection of Kestoses and Kestose-Related Oligosaccharides in Extracts of <i>Festuca arundinacea, Dactylis glomerata</i> L., and <i>Asparagus officinalis</i> L. Root Cultures and Invertase by <sup>13</sup>C and <sup>1</sup>H Nuclear Magnetic Resonance Spectroscopy (1990)

A previous study (KL Forsythe, MS Feather [1989] Carbohydr Res 185: 315-319) showed that (13)C nuclear magnetic resonance spectroscopy can be used to detect and identify mixtures of 1-kestose and neokestose after conversion to the acetate derivatives. In this study, unequivocal assignments are made for the anomeric carbon and proton signals for the above two trisaccharide acetates as well as for 6-kestose hendecaacetate and for nystose tetradecaacetate (a 1-kestose-derived tetrasaccharide). A number of oligosaccharide fractions were isolated from several plant species, converted to the acetates, and nuclear magnetic resonance spectra obtained. Using the above reference data, the following information was obtained. The trisaccharide fraction from Dactylis glomerata L. stem tissue and Asparagus officinalis L. roots contain both 1-kestose and neokestose, and the tetrasaccharide fractions contain three components, one of which is nystose. Penta- and hexasaccharide acetates were also isolated from A. officinalis L. roots and were found to contain, respectively, four and at least five components. All components of both of the above species appear to contain a kestose residue and to be produced by the sequential addition of fructofuranosyl units to these. The trisaccharide fraction from Festuca arundinacea is complex, and contains at least five different components, two of which appear to be 1-kestose and neokestose.
HeterologousHIS3 Marker and GFP Reporter Modules for PCR-Targeting inSaccharomyces cerevisiae (1997)

We have fused the open reading frames of his3-complementing genes from Saccharomyces kluyveri and Schizosac-charomyces pombe to the strong TEF gene promotor of the filamentous fungus Ashbya gossypii. Both chimeric modules and the cognate S. kluyveri HIS3 gene were tested in transformations of his3 S. cerevisiae strains using PCR fragments flanked by 40 bp target guide sequences. The 1.4 kb chimeric Sz. pombe module (HIS3MX6) performed best. With less than 5% incorrectly targeted transformants, it functions as reliably as the widely used geniticin resistance marker kanMX. The rare false-positive His+ transformants seem to be due to non-homologous recombination rather than to gene conversion of the mutated endogenous his3 allele. We also cloned the green fluorescent protein gene from Aequorea victoria into our pFA-plasmids with HIS3MX6 and kanMX markers. The 0.9 kb GFP reporters consist of wild-type GFP or GFP-S65T coding sequences, lacking the ATG, fused to the S. cerevisiae ADH1 terminator. PCR-synthesized 2.4 kb-long double modules flanked by 40-45 bp-long guide sequences were successfully targeted to the carboxy-terminus of a number of S. cerevisiae genes. We could estimate that only about 10% of the transformants carried inactivating mutations in the GFP reporter.
Solving Storage Limitations Using a Peer-to-Peer Web File System (2008)

Running out of disk space is a problem that appears more often then one would desire, even though the hard-drive capacities are becoming larger and the price per gigabyte lower. This is mainly due to the significant increase in the data manipulated by the average computer user, as well as the expected user reluctance to go out and buy another disk when the existing one is full. Besides the usual solution of deleting useless data from the hard-drive, the user can sign-up for an online backup plan, and move some files there. The paper offers an alternative solution to this problem through collaborative data storage in a peer-to-peer system. The proposed system will be made transparent to the user through a user-space file system implemented using the FUSE kernel module. The peer-to-peer communication will be done using Web Services. The data discovery will be done using the Chord algorithm.
DNA bending is induced by binding of vitamin D receptor-retinoid X receptor heterodimers to vitamin D response elements (1999)

The ability of vitamin D receptor-retinoid X receptor (VDR-RXR) heterodimers to induce a DNA bend upon binding to various vitamin D response elements (VDRE) has been investigated by circular permutation and phasing analysis. Recombinant rat VDR expressed in the baculovirus system and purified recombinant human RXR beta have been used. The VDREs were from 1,25-dihydroxyvitamin D3 (1,25-[OH]2D3) enhanced genes (rat osteocalcin, rOC; mouse osteopontin, mOP, and rat 1,25-dihydroxyvitamin D3-24-hydroxylase, r24-OHase), and a 1,25-(OH)2D3 repressed gene (human parathyroid hormone, hPTH). As shown by circular permutation analysis, VDR-RXR induced a distortion in DNA fragments containing various VDREs. Calculated distortion angles were similar in magnitude (57 degrees, 56 degrees, 61 degrees, and 59 degrees, respectively for rOC, mOP, r24-Ohase, and hPTH). The distortions took place with or without a 1,25-(OH)2D3 ligand. The centers of the apparent bend were found in the vicinity of the midpoint of all VDREs, except for rOC VDRE which was found 4 bp upstream. Phasing analysis was performed with DNA fragments containing mOP VDRE and revealed that VDR-RXR heterodimers induced a directed bend of 26 degrees, not influenced by the presence of hormone. In this study we report that similar to other members of the steroid and thyroid nuclear receptor superfamily, VDR-RXR heterodimers induce DNA bending.
Complexes of tetracyanoethylene with substituted pyridines (1969)

Figure 10.Optical spectrum of the TCNE-3,4-lutidine system in CH.Cl^ using a 0.1 mm.cell Figure 11.Optical spectrum of the TCNE-2,6-lutidine system in CH CI using a 0.1 mm.cell VI CHAPTER I * * 2 2 where a = a, b = b and a >>b .The charge-transfer absorption is
Method of Test for Fracture Toughness of Silica-Particulate-Filled Epoxide Resins and Effects of Moisture Absorption on Fracture Properties. (1996)

Silica-particulate-filled epoxide resins are used as encapsulant materials in semiconductor packaging. In the present paper, the effects of moisture absorption on the bending strength and fracture toughness of two types of the epoxide resins containing 70wt.% silica particles have been studied. The bridge indentation method was employed in precracking of specimens. The fracture toughness obtained agreed well with the results of fatigue precracked specimens. The fracture toughness of both resins slightly increased with moisture absorption while the bending strength tended to decrease. Fracture surface observation by scanning laser microscope shows that debonding of the interface between silica and epoxy predominates in the fracture surface of the bonding specimens while cracking of silica particles triggers the fracture of the precracked specimen. It is suggested that differences in bending strength and fracture toughness due to moisture absorption are attributable to differences in the stress triaxiality of the specimens.
Reliability of the Heidelberg Edge Perimeter (HEP) glaucoma screening compared to conventional 24-2-visual field tests in glaucoma patients (2016)

Purpose : Visual field testing (VFT) is an essential part of glaucoma screening and diagnosis. Conventional VFT requires time and training and to date, no gold standard for a shortened glaucoma screening VFT exists. The Heidelberg Edge Perimeter (HEP; Heidelberg Engineering) offers a glaucoma screening VF test. However, its reliability has not been assessed compared to conventional 24-2 VFT. Thus, in this study we assess the sensitivity of the HEP screening compared to Humphrey Field Analyzer (HFA II; Zeiss) VFT
Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy (2005)

The principal extracellular lesions of age-related maculopathy (ARM), the leading cause of vision loss in the elderly, involve Bruch's membrane (BrM), a thin vascular intima between the retinal pigment epithelium (RPE) and its blood supply. With age, 80-100 nm solid particles containing esterified cholesterol (EC) accumulate in normal BrM, and apolipoprotein B (apoB) immunoreactivity is detectable in BrM- and ARM-associated lesions. Yet little evidence indicates that increased plasma cholesterol is a risk factor for ARM. To determine if RPE is capable of assembling its own apoB-containing lipoprotein, we examined RPE for the expression of microsomal triglyceride transfer protein (MTP), which is required for this process. Consistent with previous evidence for apoB expression, MTP is expressed in RPE, the ARPE-19 cell line, and, unexpectedly, retinal ganglion cells, which are neurons of the central nervous system. De novo synthesis and secretion of neutral lipid by ARPE-19 was supported by high levels of radiolabeled EC and triglyceride in medium after supplementation with oleate. Lipoprotein assembly and secretion is implicated as a constitutive retinal function and a plausible candidate mechanism involved in forming extracellular cholesterol-containing lesions in ARM. The pigmentary retinopathy and neuropathy of abetalipoproteinemia (Mendelian Inheritance of Man 200100; Bassen-Kornzwieg disease), which is caused by mutations in the MTP gene, may involve loss of function at the retina.
Different Modes of Interaction in Cyanobacterial Complexes of Plastocyanin and Cytochrome<i>f</i> (2005)

The highly efficient electron-transfer chain in photosynthesis demonstrates a remarkable variation among organisms in the type of interactions between the soluble electron-transfer protein plastocyanin and it partner cytochrome f. The complex from the cyanobacterium Nostoc sp. PCC 7119 was studied using nuclear magnetic resonance spectroscopy and compared to that of the cyanobacterium Phormidium laminosum. In both systems, the main site of interaction on plastocyanin is the hydrophobic patch. However, the interaction in the Nostoc complex is highly dependent on electrostatics, contrary to that of Phormidium, resulting in a binding constant that is an order of magnitude larger at low ionic strength for the Nostoc complex. Studies of the mixed complexes show that these differences in interactions are mainly attributable to the surface properties of the plastocyanins.
Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling (2006)

Influenza A virus NS1 is a multifunctional protein, and in virus-infected cells NS1 modulates a number of host-cell processes by interacting with cellular factors. Here, we report that NS1 binds directly to p85beta, a regulatory subunit of phosphatidylinositol-3-kinase (PI3K), but not to the related p85alpha subunit. Activation of PI3K in influenza virus-infected cells depended on genome replication, and showed kinetics that correlated with NS1 expression. Additionally, it was found that expression of NS1 alone was sufficient to constitutively activate PI3K, causing the phosphorylation of a downstream mediator of PI3K signal transduction, Akt. Mutational analysis of a potential SH2-binding motif within NS1 indicated that the highly conserved tyrosine at residue 89 is important for both the interaction with p85beta, and the activation of PI3K. A mutant influenza virus (A/Udorn/72) expressing NS1 with the Y89F amino acid substitution exhibited a small-plaque phenotype, and grew more slowly in tissue culture than WT virus. These data suggest that activation of PI3K signaling in influenza A virus-infected cells is important for efficient virus replication.
Adaptive multisensor target detection using feature-based fusion (2002)

Target detection techniques play an important role in automatic target recognition (ATR) systems because overall ATR performance depends closely on detection results. We propose a multisensor target detection technique based on adaptive feature-based fusion suitable to detect low-contrast and/or blurry targets with relatively low computational complexity. The proposed technique extracts four different features designed to find regions of high contrast, strong edges, or high information content. The proposed multisensor target-detection technique incorporates multiple imaging sensors in different spectral ranges, such as the visible, near-infrared, and far-infrared bands. The images from the multiple sensors are jointly processed via feature extraction and multisensor fusion. In the multisensor fusion process, a multisensor confidence image is created by adaptively combining the features generated from the multisensor images to obtain more accurate potential target locations. Experimental results on multisensor test sequences are provided.
Timing Synchronization for Real-Valued Orthogonal Space-Time Block Codes (2006)

Low complexity timing error detectors for rate one orthogonal space-time block codes with real modulation are presented. For 2-, 3- and 4-transmit antenna codes, we derive robust timing error estimators and obtain analytical expressions for the estimation error variance and the signal-to-noise ratio. The performance is evaluated by examining the estimator's tracking capabilities in a system operating over a frequency-flat Rayleigh fading environment. The bit-error-rate results are presented showing degradation due to timing synchronization of less than 0.5 dB. In addition, we study the performance as a function of the timing drift and show that the timing loop is able to track up to normalized timing drift bandwidth of 0.001. Perfect channel state information at the receiver is assumed throughout the paper
Cardiogenic Shock in Patients With Acute Ischemic Syndromes With and Without ST-Segment Elevation (1999)

Cardiogenic shock occurs in the setting of acute ischemic syndromes regardless of whether ST-segment elevation is present. The incidence, patient characteristics, timing, clinical course, and angiographic findings differ between the 2 groups. Mortality from cardiogenic shock is similarly high among patients with and without ST-segment elevation.
Bromination of Halobenzenes<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBromination of Halobenzenes1Lloyd N. Ferguson, Albert Y. Garner, and Julius L. MackCite this: J. Am. Chem. Soc. 1954, 76, 5, 1250–1251Publication Date (Print):March 1, 1954Publication History Published online1 May 2002Published inissue 1 March 1954https://pubs.acs.org/doi/10.1021/ja01634a013https://doi.org/10.1021/ja01634a013research-articleACS PublicationsRequest reuse permissionsArticle Views589Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Stable carbonium ions. XCIII. Protonated thion esters and dithio esters and their cleavage in fluorosulfuric acid-antimony pentafluoride solution (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable carbonium ions. XCIII. Protonated thion esters and dithio esters and their cleavage in fluorosulfuric acid-antimony pentafluoride solutionGeorge A. Olah and Alice T. KuCite this: J. Org. Chem. 1970, 35, 2, 331–335Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/jo00827a008https://doi.org/10.1021/jo00827a008research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Convex Programming Color Constancy (2003)

Gamut mapping color constancy algorithms (originally introduced by Forsyth[For90]) attempt to map RGBs of surfaces viewed under an unknown light to corresponding RGBs under a known reference illuminant. With respect to a reference light source the set of all observable RGBs occupies a 3-dimensional convex region, or gamut, of RGB space. If a triple of 3 simple scalar factors defines the map from image colors to reference conditions then it has been shown that the set of all maps taking RGBs into the reference gamut is also a convex set. Gamut mapping algorithms work in 2 stages. First, the set of feasible maps is computed then in a second stage an optimal member of this map set is chosen. Here we show that feasible map set does not need to be computed. Rather we combine the final map selection stage with the enforcement of the constraint that image colors are mapped inside the reference gamut. The main contribution of this paper is to show that this combined computation can be set up as a simple convex programming problem. Two main advantages result from this reformulation of gamut mapping. First, several reasonable designations of ‘optimal’ map can be formulated and tested within the convex programming framework. If we maximize the sum of the triplet of map parameters then color constancy is shown to be a linear programming problem. Maximizing the Euclidean magnitude of the mapping triplet gives a quadratic programming formulation and maximizing the volume of the mapped image gamut (Forsyth’s original gamut mapping algorithm) is also possible The second advantage is that convex programming provides a fast solution to the color constancy problem. Indeed, we show that linear programming color constancy is a strictly more efficient implementation of gamut mapping compared to previous methods. Experiments indicate that, for the Simon Fraser Data set (synthetic and real images), linear programming color constancy provides the best performance over all the convex programming methods tested.
Phase II trial of the phosphatidyinositol-3 kinase (PI3K) inhibitor buparlisib (BKM120) in recurrent glioblastoma. (2014)

2019 Background: The PI3K pathway is activated in most GBMs and represents a potential therapeutic target. Buparlisib is an oral, pan-Class I PI3K inhibitor that enters the brain at therapeutic concentrations and inhibits the growth of U87 and GBM PDX models. Methods: The Ivy Consortium conducted a phase II study of buparlisib in recurrent GBM patients with activation of the PI3K pathway (mutation, homozygous deletion or loss of immunohistochemistry (IHC) of PTEN, PIK3CA or PIK3RI mutations, or detectable pAKT). Additional eligibility criteria included radiologic progression, 1st or 2nd relapse, > 18 yrs, KPS > 60, adequate bone marrow and organ function, no prior bevacizumab or enzyme-inducing antiepileptic drugs. Patients received buparlisib 100mg daily. The study consisted of 2 concurrent cohorts. In Cohort 1 (up to 15 patients) buparlisib was given for 8-12 days prior to surgery for recurrent disease. Patients underwent FDG PET, pharmacokinetic studies, and tumor obtained for drug concentrations and pharmacodynamic effects. In Cohort 2, 50 patients with unresectable GBM received buparlisib with a . primary endpoint of PFS6. Results: 13 patients have been enrolled into cohort 1, 50 into cohort 2. Treatment was well-tolerated with no grade 4 toxicities. Grade 3 toxicities were asymptomatic lipase elevation (6), rash (4), hyperglycemia (3), fatigue (4), elevated ALT/AST (2), and 1 each of depression, anxiety, hypophosphatemia, thrombocytopenia and lymphopenia. Analysis of tumor specimens from Cohort 1 showed reduction of pAKTS473 by IHC in 4/6 (67%) of evaluable patients. The combined cohorts showed minimal efficacy with median PFS of 1.8 months and median OS of 10.9 months. Best response was stable disease. Only 1 patient in each cohort achieved PFS6. Of the first 40 patients who underwent exome sequencing, there were 4 PIK3CA (10%), 2 PIK3R1 (5%), and 13 PTEN (33%) mutations. Patients with PTEN loss and or PI3K mutations paradoxically had a worse outcome. Conclusions: Buparlisib is well-tolerated in patients with recurrent GBM and achieves adequate tumor concentration to inhibit pAKTS473. However, single agent efficacy was minimal. Final correlation of tumor genotype with outcome will be presented.