gebhart/patrepeval huggingface dataset:
CBP/p300 and SIRT1 Are Involved in Transcriptional Regulation of S-Phase Specific Histone Genes (2011)

These observations contribute to further understanding of the mechanism by which the expression of canonical histone genes is regulated, and also implicate a link between histone expression and DNA damage repair and cell metabolism.
Minimal dimension realization and identifiability of input-output sequences (1977)

A necessary and sufficient condition of identifiability of an input-output sequence is given. An algorithm is presented by which a minimal dimension realization from a given input-output sequence can be obtained. A canonical input-output equation is introduced. It is shown that the state equation realization from a canonical input-output equation exists and is unique, up to an isomorphism.
“Actividades enredadas”: Proyecto ciencia entre todos. Relato de experiencias significativas (2009)

En este trabajo se presenta una propuesta que denominamos Ciencia entre todos para jóvenes con mejor futuro (CET) orientada al mejoramiento de la calidad de enseñanza y del aprendizaje de las Ciencias Naturales en cinco escuelas de nivel medio de diferentes localidades de la Provincia de Buenos Aires. Para concretar este objetivo se concretó un equipo en re coordinado a través de CIAEC (Centro de Investigación y Apoyo para la Enseñanza de las Ciencias). Las acciones implementadas en el marco de la red incluyeron el intercambio de información y materiales entre los participantes u las “actividades enredadas” que aquí presentamos.
XII. <i>On the diffraction theory of microscopic vision</i> (1906)

(1906). XII. On the diffraction theory of microscopic vision. The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science: Vol. 11, No. 61, pp. 154-166.
Histamine H<sub>1</sub>-receptor blockade in humans affects psychomotor performance but not memory (2008)

Results from recent animal studies suggest an important role for histamine in memory functioning. Histaminergic drugs might prove beneficial for people suffering from memory impairment. To determine if histamine is involved in memory functioning this study evaluates the effects of histaminergic dysfunction on memory performance by administrating a H1-antagonist to humans. The study was conducted according to a 4-way, double-blind, crossover design in 20 healthy female volunteers, aged 18-45 years. On each test day subjects completed three test sessions: before and around 2 and 4 h after administration of single oral doses of dexchlorpheniramine 2 mg or 4 mg, scopolamine 1 mg or placebo. Drug effects were assessed using tests of memory, psychomotor and attention performance, and subjective alertness. Results showed that dexchlorpheniramine impaired performance in tests of spatial learning, reaction time, tracking and divided attention but showed no effects on working memory, visual memory, word learning or memory scanning. Scopolamine induced a similar pattern of effects. In addition, both drugs decreased subjective alertness. In conclusion results show that dexchlorpheniramine and scopolamine clearly impaired performance on psychomotor and attention tasks but do not suggest a specific role of the histaminergic system in learning and memory in humans.
Oligoclonal T Cell Expansions in Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice (2000)

T cells are present in atherosclerotic lesions at all stages of development. They exhibit activation markers and are particularly prominent at sites of plaque rupture. This suggests that T-cell-mediated immune responses are involved in the pathogenesis of atherosclerosis. Antigen-specific T cells reactive with oxidized lipoproteins and heat shock proteins have been isolated from plaques, indicating that local activation and clonal expansion might occur. To analyze different stages of atherosclerosis, we have used a murine model. Targeted deletion of the apolipoprotein E gene results in severe hypercholesterolemia and spontaneous atherosclerosis, with lesions containing large numbers of T cells and macrophages. We have analyzed mRNA for T-cell antigen receptors (TCRs) from aortic fatty streaks, early fibrofatty plaques, and advanced fibrofatty plaques of such mice. Polymerase chain reaction amplification of complementarity-determining region 3 (CDR3 region) of TCRs was followed by spectratyping of fragment lengths. This analysis detected all types of variable (V) segments with a gaussian distribution of CDR3 in lymph nodes. In contrast, a restricted heterogeneity was found in atherosclerotic lesions, with expansion of a limited set of Vbeta and Valpha segments and a monotypic or oligotypic CDR3 spectrum in each lesion. Vbeta6 was expressed in all lesions; Vbeta5.2, Vbeta16, Valpha34s, and Valpha9, in the majority of lesions; and Vbeta6, Vbeta5.2, and Valpha34S, in lesions at all 3 stages of development. The strongly skewed pattern of the CDR3 region in the TCR is indicative of oligoclonal expansions of T cells and suggests the occurrence of antigen-driven T-cell proliferation in atherosclerosis.
GnRH analogues: applications in assisted reproductive techniques (2008)

The ability to prevent an endogenous LH surge revolutionised the efficacy of assisted reproductive techniques (ART) such that GnRH agonists were rapidly adopted in the 1980s. Prior to this, premature luteinisation occurred in up to 25% of superovulated cycles leading to cycle cancellation and severely compromised outcomes. Analogues have been applied in a variety of drug protocols (long, short flare) but there has been little research to moderate the degree of pituitary suppression. There has also been ongoing and unresolved debate about the role of LH in supporting follicular development. By 2001, the first GnRH antagonists were registered for use in ART. Their ability to cause immediate suppression of gonadotrophin (particularly LH) secretion means that they can be given after exogenous stimulation has begun and thereby dramatically shorten the total duration of a treatment cycle. After initial enthusiasm and then scepticism that pregnancy rates may not be as high as the established agonist regimens, these preparations are now being increasingly adopted with at least comparable outcomes in large trials. They are certainly favoured by patients for their reduced side-effect profile and particularly for the shortening of the total cycle length. This shift in practice is occurring alongside gathering momentum in favour of milder stimulation protocols and a new perception of what constitutes successful treatment. The focus is moving away from surrogate outcomes such as oocyte numbers and conception rates towards long-term outcomes for women and their offspring, namely the achievement of a live singleton birth per treatment started.
Learn Microservices with Spring Boot (2020)

This book shows how to build Java-based microservices using the Spring Boot 3 framework by evolving an application.
Elastic properties of graphene grown by chemical vapor deposition (2015)

We measured the elastic properties and breaking strength of free-standing chemical vapor deposition grown graphene membranes by nanoindentation with an atomic force microscope probe in scanning electric microscope. The force-displacement behavior presents to be nonlinear elastic stress-strain response. The two dimension elastic constant and fracture are extracted to be 337 N/m and 179 GPa, respectively. The corresponded effective Young's modulus is E = 1 TPa, compared to 1 TPa for graphene produced by mechanical exfoliation of graphite and 0.25 TPa for graphene produced by chemical reduction.
ATHEROSCLEROSIS OF THE CAROTID AND VERTEBRAL ARTERIES—EXTRACRANIAL AND INTRACRANIAL (1965)

Journal Article Atherosclerosis of the Carotid and Vertebral Arteries—Extracranial and Intracranial Get access C. M. Fisher, M.D., C. M. Fisher, M.D. Boston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Gore, M.D., I. Gore, M.D. Boston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Okabe, M.D., N. Okabe, M.D. Boston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar P. D. White, M.D. P. D. White, M.D. Boston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Neuropathology & Experimental Neurology, Volume 24, Issue 3, July 1965, Pages 455–476, https://doi.org/10.1097/00005072-196507000-00007 Published: 01 July 1965
Microstructural differences between single-species and dual-species biofilms of Streptococcus mutans and Veillonella parvula, before and after exposure to chlorhexidine (2007)

Dual-species biofilms of Streptococcus mutans and Veillonella parvula are less susceptible to antimicrobials than single-species biofilms of the same microorganisms. The microstructure of single and dual-species biofilms of S. mutans and/or V. parvula was visualized to find out whether the spatial arrangement of bacteria in biofilms is related to survival strategies against antimicrobials. Biofilms were grown in glass-bottomed 96-well microtiter plates and exposed to chlorhexidine at 48 h. Fluorescent probes were used for staining. The microstructure of biofilms was analyzed by confocal scanning laser microscopy at 48, 96, 192, and 264 h. Spatial arrangement analysis was performed using DAIME software for 48 h biofilms. A decrease in the viability and thickness in all types of biofilms was detected after chlorhexidine treatment in time. In untreated biofilms, clustering was observed. In chlorhexidine-treated single-species biofilms, bacteria were dispersed. However, the most prominent clustering was observed in chlorhexidine-treated dual-species biofilm bacteria, which had a higher survival rate compared with chlorhexidine-treated single-species biofilms. Bacteria in dual-species biofilms establish a specific spatial arrangement, forming clusters within distances below 1.2 microm as a survival strategy against antimicrobials while the same bacteria lack this defensive construction in a single-species biofilm
Performance of the ‘Unaffected’ Upper Extremity of Elderly Stroke Patients (1996)

Many factors (frequency of use of the unaffected hand, sensorimotor interaction tasks, severity of the deficits in corticifugal projections, and deficits in postural stabilization) could interact to provide the clinical picture obtained in the present study.
Characteristics of the Si-SiO2 interface states in thin (70–230 Å) oxide structures (1987)

Important characteristics of the Si-SiO2 interface states, such as the interface state density distributions and the electron and the hole capture cross section versus energy profiles, were investigated in unannealed metal/silicon dioxide/silicon (MOS) structures with the gate oxide thickness in the range of 70–230 Å, using the optical MOS admittance technique. The experimentally obtained interface state density distribution, in case of p-Si/SiO2/Al structures, exhibited two peaked profiles, one near the valence-band edge Ev and the other near the conduction-band edge Ec, overlying a concave background. The state density at the peak was observed to undergo a maximum, preceded by a minimum, as the gate oxide thickness tox was increased. The peak energy versus tox and the capture cross section versus tox profiles also indicated strong features.
Histological evaluation of mineral trioxide aggregate and calcium hydroxide in direct pulp capping of human immature permanent teeth. (2008)

Forty-four of 48 teeth were suitable for microscopic evaluation, 30 with WMTA, 14 with CH. Of the WMTA group, 29 teeth were vital, 28 had formed a bridge, and one specimen had failed. Twelve of 14 teeth with CH were vital, while three teeth failed to form a bridge. No statistically significant differences between WMTA and CH were found, except for superficial and deep inflammatory cell response (P < or = 0.05). Pulp capping of intentionally exposed human immature premolars performed slightly better when using MTA.
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain (2012)

Exploring the role of cannabinoid CB(2) receptors in the brain, we present evidence of CB(2) receptor molecular and functional interaction with cannabinoid CB(1) receptors. Using biophysical and biochemical approaches, we discovered that CB(2) receptors can form heteromers with CB(1) receptors in transfected neuronal cells and in rat brain pineal gland, nucleus accumbens, and globus pallidus. Within CB(1)-CB(2) receptor heteromers expressed in a neuronal cell model, agonist co-activation of CB(1) and CB(2) receptors resulted in a negative cross-talk in Akt phosphorylation and neurite outgrowth. Moreover, one specific characteristic of CB(1)-CB(2) receptor heteromers consists of both the ability of CB(1) receptor antagonists to block the effect of CB(2) receptor agonists and, conversely, the ability of CB(2) receptor antagonists to block the effect of CB(1) receptor agonists, showing a bidirectional cross-antagonism phenomenon. Taken together, these data illuminate the mechanism by which CB(2) receptors can negatively modulate CB(1) receptor function.
A CMOS low-IF programmable gain amplifier with speed-enhanced DC offset cancellation (2003)

This paper presents a programmable gain amplifier (PGA) for a dual band (GSM900/DCS1800) low-IF receiver. It uses a negative feedback approach to achieve the high linearity requirement. In addition to the amplifier, anti-alias filtering and DC offset removal are included for the subsequent IF signal processing. A dual-bandwidth algorithm is developed to speed up the settling time on DC removal. A modified Sallen-Key filter helps to provide better than 40 dB anti-aliasing and blocker attenuation near the sampling frequency of 13 MHz. The overall PGA gain varies from 0 dB to 46 dB with 2 dB per step. With a 0.25 /spl mu/m CMOS process, this device dissipates 10.3 mW from a 2.7 V supply voltage.
Light chain (AL) amyloidosis: update on diagnosis and management (2011)

Light chain (AL) amyloidosis is a plasma cell dyscrasia characterized by the pathologic production of fibrillar proteins comprised of monoclonal light chains which deposit in tissues and cause organ dysfunction. The diagnosis can be challenging, requiring a biopsy and often specialized testing to confirm the subtype of systemic disease. The goal of treatment is eradication of the monoclonal plasma cell population and suppression of the pathologic light chains which can result in organ improvement and extend patient survival. Standard treatment approaches include high dose melphalan (HDM) followed by autologous hematopoietic stem cell transplantation (SCT) or oral melphalan with dexamethasone (MDex). The use of novel agents (thalidomide, lenalidomide and bortezomib) alone and in combination with steroids and alkylating agents has shown efficacy and continues to be explored. A risk adapted approach to SCT followed by novel agents as consolidation reduces treatment related mortality with promising outcomes. Immunotherapeutic approaches targeting pathologic plasma cells and amyloid precursor proteins or fibrils are being developed. Referral of patients to specialized centers focusing on AL amyloidosis and conducting clinical trials is essential to improving patient outcomes.
Development of a sequential extraction method for different forms of phosphorus in marine sediments (1992)

A sequential extraction method (SEDEX) has been developed to separately quantify five sedimentary P reservoirs: loosely sorbed P; ferric iron‐bound P; authigenic carbonate fluorapatite + biogenic apatite + CaCO 3 ‐associated P; detrital apatite P; and organic P. The SEDEX method successfully separates two of the main categories of authigenic phosphate phases called upon most often as sedimentary sinks for diagenetically mobilized P: ferric oxyhydroxide‐associated P and authigenic carbonate fluorapatite (CFAP). It offers a means for separating authigenic CFAP from detrital apatite of igneous or metamorphic origin. The importance of this distinction is that CFAP represents an oceanic sink for reactive P, whereas detrital apatite does not. In addition, a means for reversing secondary adsorption of P onto residual solid surfaces during extraction has been developed. Extensive standardization of the SEDEX method for application to marine sediments has been performed with analogs for naturally occurring phosphatic phases.
Underestimated Cost of Targeted Attacks on Complex Networks (2018)

The robustness of complex networks under targeted attacks is deeply connected to the resilience of complex systems, which is defined as the ability to make appropriate response to the attack. In this paper, we study robustness of complex networks under a realistic assumption that the cost of removing a node is not constant but rather proportional to the degree of a node or equivalently to the number of removed links a removal action produces. We have investigated the state‐of‐the‐art targeted node removing algorithms and demonstrate that they become very inefficient when the cost of the attack is taken into consideration. For the case when it is possible to attack or remove links, we propose a simple and efficient edge removal strategy named Hierarchical Power Iterative Normalized cut (HPI‐Ncut). The results on real and artificial networks show that the HPI‐Ncut algorithm outperforms all the node removal and link removal attack algorithms when the same definition of cost is taken into consideration. In addition, we show that, on sparse networks, the complexity of this hierarchical power iteration edge removal algorithm is only O ( n log 2+ε ⁡ n ).
Simple trimerization of 2,3-butanedione yielding a selective reagent for the modification of arginine in proteins (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple trimerization of 2,3-butanedione yielding a selective reagent for the modification of arginine in proteinsJohn A. Yankeelov Jr., Carolyn Dempsey Mitchell, and Thomas H. CrawfordCite this: J. Am. Chem. Soc. 1968, 90, 6, 1664–1666Publication Date (Print):March 1, 1968Publication History Published online1 May 2002Published inissue 1 March 1968https://pubs.acs.org/doi/10.1021/ja01008a056https://doi.org/10.1021/ja01008a056research-articleACS PublicationsRequest reuse permissionsArticle Views357Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Authoring and Visualization Tool for Augmented Scenic Performances Prototyping and Experience (2020)

There is a growing interest in the use of Augmented Reality technologies in artistic practices for performance execution and its use in the production process. The ability to overlay visual media onto the real world or, more specific onto the performer body in real-time has also captured the imagination of performance artists. Also, directors and choreographers glimpse the uses and applications of augmented reality in their production workflow. These applications provide specific challenges that require adaptations to standard content creation workflows. The present work describes the design and implementation of an authoring application for AR-based performance art, initially developed to support augmented performances but also extended to the prototyping of choreographies and costumes uses. The application enables several virtual augmented effects like images, videos, and 3D models to be attached simultaneously to the performer's body. This paper is presented as an application presentation providing a general view of the proposed solution and describing its development. We may see the effectiveness of the authoring application and establishes concrete requirements for a more generic tool to support the development of Artistic Performances with Augmented Reality.
Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation (2011)

Canonical autophagy is positively regulated by the Beclin 1/phosphatidylinositol 3-kinase class III (PtdIns3KC3) complex that generates an essential phospholipid, phosphatidylinositol 3-phosphate (PtdIns(3)P), for the formation of autophagosomes. Previously, we identified the human WIPI protein family and found that WIPI-1 specifically binds PtdIns(3)P, accumulates at the phagophore and becomes a membrane protein of generated autophagosomes. Combining siRNA-mediated protein downregulation with automated high through-put analysis of PtdIns(3)P-dependent autophagosomal membrane localization of WIPI-1, we found that WIPI-1 functions upstream of both Atg7 and Atg5, and stimulates an increase of LC3-II upon nutrient starvation. Resveratrol-mediated autophagy was shown to enter autophagic degradation in a noncanonical manner, independent of Beclin 1 but dependent on Atg7 and Atg5. By using electron microscopy, LC3 lipidation and GFP-LC3 puncta-formation assays we confirmed these results and found that this effect is partially wortmannin-insensitive. In line with this, resveratrol did not promote phagophore localization of WIPI-1, WIPI-2 or the Atg16L complex above basal level. In fact, the presence of resveratrol in nutrient-free conditions inhibited phagophore localization of WIPI-1. Nevertheless, we found that resveratrol-mediated autophagy functionally depends on canonical-driven LC3-II production, as shown by siRNA-mediated downregulation of WIPI-1 or WIPI-2. From this it is tempting to speculate that resveratrol promotes noncanonical autophagic degradation downstream of the PtdIns(3)P-WIPI-Atg7-Atg5 pathway, by engaging a distinct subset of LC3-II that might be generated at membrane origins apart from canonical phagophore structures.
The Fee Simple Conditional in South Carolina (1966)

is made by the annotation on the subject in 114
The expression of toll-like receptor 2, 4 of livers in mice with systemic inflammatory response syndrome. (2006)

The expressions of TLR2, 4 of livers were increased markedly in SIRS mice, indicating that TLR might play an important role in the pathogenesis of SIRS.
A First Experience with Spatial Audio in a Virtual Environment (1993)

This report describes a first attempt to use 3-D audio in a virtual environement and the lessons learned from the experience. KEYWORDS virtual reality, virtual environments, spatial audio, multimedia, man-machine interfaces, human-computer interfaces, audio choreography INTRODUCTION While many Virtual Reality systems include sound as a part of the virtual environment, it never receives as much attention as the video gear; thousands of dollars are spent for head trackers and helmet mounted displays (HMD&apos;s), while no special audio equipment is used. Some systems do not even use headphones, though these are considerably less expensive than any visual HMD. Virtual reality research at Georgia Tech already uses sound, but no spatialization is applied. Auditory cues provide positive or negative feedback while performing an interactive task. With typical VR tasks as grabbing and pointing at objects, or navigating trough space, user performance is restricted by the lack of accuracy of the tr...