gebhart/patrepeval huggingface dataset:
Role of Wnt Signaling in Tissue Fibrosis, Lessons from Skeletal Muscle and Kidney (2014)

Several studies have provided clear evidence of the importance of Wnt signaling in the function of several tissues. Wnt signaling has been related to several cellular processes including pre-natal development, cell division, regeneration and stem cell generation. By contrast, deregulation of this pathway has been associated with several diseases such as cancer, Alzheimer's disease, diabetes and, in recent years, fibrotic diseases in tissues such as skeletal muscle and kidney. Fibrotic diseases are characterized by an increase in the production and accumulation of extracellular matrix (ECM) components leading to the loss of tissue architecture and function. In a classical view, several molecules are related to the establishment of the fibrotic condition, including angiotensin II, transforming growth factorβ(TGF-β) and the connective tissue growth factor (CTGF) and a crosstalk has been suggested between these signaling molecules and the Wnt pathway. Skeletal muscle fibrosis, the most common disease, is typical of muscle dystrophies, where deregulation of the regenerative process in postnatal muscle leads to fibrotic differentiation and eventually to the failure of skeletal muscle. The fibrotic condition is also present in kidney pathologies such as polycystic kidney disease (PKD), in which fibrosis leads to a loss of tubule architecture and to a loss of function, which in almost all cases requires kidney surgery. A new actor in the pro-fibrotic effect of Wnt signaling in the kidney has been described, the primary cilium, an organelle that plays an important role in the onset of fibrosis. The aim of this review is to discuss the pro-fibrotic effect of Wnt signaling in both skeletal muscle and kidney, and to try to understand how this pathway is associated with the TGF-β, CTGF and angiotensin II pro-fibrotic pathway.
Subunit Structure of Eutherian Sperm Chromatin (1978)

The beta-mercaptoethanol induced decondensation of spermatozoon cell nuclei from several Eutherian species has been followed from the intact spermatazoon cell to the solubilized linear unit sperm chromosomal fiber using fluorescence and electron microscopy. Data from nuclease digestion studies in conjunction with electron microscopic evidence indicate that the gross structure of the unit Eutherian sperm chromosomal fiber consists of DNA folded around sperm specific histone multimers spaced regularly along the fiber generating a linear array of sperm nucleosomes connected by short stretches of uncomplexed DNA. The sperm nucleosomes, 80 A in diameter are separated by 20 A filaments of DNA. This structure is remarkably similar to the structure of somatic chromatin although the protein components of the two chromosomes are markedly different. It seems likely that chromosomal fibers, similar to those described herein, may be present in the male pronucleus following fertilization.
Alpha Solarco's high-concentration photovoltaic array development program (1988)

The design and planned production of a cost-effective, high-concentration point-focus Si array for utility-scale applications is discussed. Design considerations such as cell assemblies, optics, modules, and arrays are also discussed. The results indicate that the goals of high reliability, low maintenance, long system life, and an installed cost on the order of $2 per peak watt are achievable in the near term.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Stacking of Planar SOFCs (1995)

In the Danish SOFC programme major emphasis is placed on R&D leading towards manufacture and test of a 1/2-1kW stack based on the planar cross flow design. Small stacks have been built and tested. A number of challenges are encountered when building planar stacks. Two are being dealt with in the present paper: (i) attaining operational seals for electrodes and manifolds and (ii) minimizing the difference in thermal expansion between the yttria stabilized zirconia-electrolyte and the LaCrO3-based interconnect material.
Single Parameter Fault Identification Technique for DC Motor through Wavelet Analysis and Fuzzy Logic (2013)

DC motors are widely used in industries like cement, paper manufacturing, etc., even today. Early fault identification in dc motors significantly improves its life time and reduces power consumption. Many conventional and soft computing techniques for fault identification in DC motors including a recent work using model based analysis with the help of fuzzy logic are available in literature. In this paper fuzzy logic and norm based wavelet analysis of startup transient current are proposed to identify and quantify the armature winding fault and bearing fault in DC motors, respectively. Results obtained by simulation using Matlab and Simulink are presented in this paper to validate the proposed work.
Pyrotechnic shaped charge separation systems for aerospace vehicles (1968)

Pyrotechnic shaped charge aerospace vehicle stage and shroud separation systems development
Approximate Dynamic Modeling of Large Staged Systems (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApproximate Dynamic Modeling of Large Staged SystemsChangse Kim and John C. FriedlyCite this: Ind. Eng. Chem. Process Des. Dev. 1974, 13, 2, 177–181Publication Date (Print):April 1, 1974Publication History Published online1 May 2002Published inissue 1 April 1974https://pubs.acs.org/doi/10.1021/i260050a014https://doi.org/10.1021/i260050a014research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Central area properties redevelopment scheme for the Auckland Harbour board (1965)

The paper, by R. A. I. Smith, was published in Vol. 20, No. 10, pp. 402-8 (October 1965). It sets down the various steps taken in preparing and launching a project designed to bring about the redevelopment of a 32 acre area of Auckland's central business district.
Pooley: Mason Pooley (1924)

Journal Article Pooley: Mason Pooley Get access R. Bingham Adams R. Bingham Adams Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CXLVII, Issue nov01, 1 November 1924, Page 318, https://doi.org/10.1093/nq/CXLVII.nov01.318 Published: 01 November 1924
The Finkelstein Reaction: Quantitative Reaction Kinetics of an SN2 Reaction Using Nonaqueous Conductivity (2006)

Two essential concepts for students to grasp in the undergraduate organic chemistry sequence are substitution chemistry and elimination chemistry (SN1/SN2 and E1/E2). However, students are often confounded by the seemingly endless series of structure–reactivity relationships. This dualistic relationship of conceptual essentialness and student confusion usually results in a line of demarcation for many second-year organic chemistry students. It is at this point that students either pull together the fundamental structure–reactivity relationships and go on to draw relevant mechanistic conclusions that underpin the balance of their organic chemistry experience or the flood of material washes over them and they wind up in a miserable struggle to keep their heads above water until the end of the spring semester. Therefore, we have developed a quantitative kinetics laboratory exercise featuring the Finkelstein reaction (SN2) for use in the first-semester organic chemistry course that utilizes nonaqueous conductivity as the method by which relevant structure–temperature–solvent effects are examined.
Another timetabling approach (1990)

All over the world, automatic university timetabling has been a difficult problem to solve. The authors have thus developed an interactive timetabling system for the Faculty of Sciences and Technology of the Universidade Nova de Lisboa, based on concepts of decision support and expert systems, that attempts to overcome the weaknesses of previous methods. The system uses several criteria to qualify a proposed timetable, whose relative importance may be adjusted by the user. The weighting of the criteria is a subjective factor affecting the system globally and the solution proposed by the system might not reflect, locally, the expectations of the user when he/she defined the weights. To overcome this problem, the system is highly interactive, allowing the user to test and compare alternative scenarios based on local modifications, providing for each, a total weight that measures the quality of the scenarios. The system also provides very complete report writing capabilities. Finally, the sophisticated graphical interface provided by the system, greatly facilitates the user's dialog. The authors describe the main features of their timetabling system. >
Investigations on the Role of Foam Layers in the Failure of Glass-Epoxy Composite Subjected to Repeated Impacts (1998)

The comparative performance of repeatedly low mass pendulum impacted glass-epoxy (G-E) composites without and with the inclusion of either two or three (sheet) layers of flexible foam at the mid-region of the laminate is reported. Using square cross section specimens, the orientation of the test coupon was altered with respect to the impact direction such that in one case the G-E part, and the foam layers, constituting the system, were lying parallel (edgewise) and in the second case perpendicular (flatwise). The features of impact tested coupons, observed through macroscopy, were correlated with the mechanical data.
Substituent effects in the keto-enol tautomerism of fused 1,4-naphthalenediols (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituent effects in the keto-enol tautomerism of fused 1,4-naphthalenediolsMyrna S. Pearson, Barbara J. Jensky, Francis X. Greer, Janice P. Hagstrom, and Nancy M. WellsCite this: J. Org. Chem. 1978, 43, 24, 4617–4622Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/jo00418a017https://doi.org/10.1021/jo00418a017research-articleACS PublicationsRequest reuse permissionsArticle Views602Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Decanuclear homo- and heterometallic polypyridine complexes: syntheses, absorption spectra, luminescence, electrochemical oxidation, and intercomponent energy transfer (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDecanuclear homo- and heterometallic polypyridine complexes: syntheses, absorption spectra, luminescence, electrochemical oxidation, and intercomponent energy transferGianfranco Denti, Sebastiano Campagna, Scolastica Serroni, Mauro Ciano, and Vincenzo BalzaniCite this: J. Am. Chem. Soc. 1992, 114, 8, 2944–2950Publication Date (Print):April 1, 1992Publication History Published online1 May 2002Published inissue 1 April 1992https://pubs.acs.org/doi/10.1021/ja00034a029https://doi.org/10.1021/ja00034a029research-articleACS PublicationsRequest reuse permissionsArticle Views958Altmetric-Citations280LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CONTRIBUTION TO THE PALEONTOLOGY, STRATIGRAPHY AND PALEO-BIOGEOGRAPHY OF SOME DIAGNOSTIC PAKISTANIAN PALEOGENE FORAMINIFER IN THE MIDDLE EAST (2019)

This paper deals with new information on paleontology and stratigraphy of eighteen Pakistanian Paleogene foraminiferal species and its paleogeographic distribution in the Tethyan Middle East. These species are: Tritaxia elongata, T. limbata, Siphogaudryina daviesi, S. elongata, Textularia sp. (=T. farafraensis, T. punjabensis, Pseudoclavulina pseudohumilis (=P.farafraensis), Globanomalina ovalis (=G. luxorensis, Fursenkoina dubia, Sakhiella nammalensis, Valvulineria nammalensis, Discorbis globiformis, Cibicidoides grandis, C. nammalensis, Rectoeponides dubia (=Karreria fallax), Ornatanomalina hafeezi and Pararotalia khirthari. One of the illustrated species is believed to be new: Nonionella haquei Anan, n. sp. Detailed study of rich and well preserved Pakistanian taxa were introduced by Haque made it possible to correlate them with those previously identified species in the coeval sequence
A hot-carrier degradation mechanism and electrical characteristics in S/sup 4/D n-MOSFET's (1997)

A silicided silicon-sidewall source and drain (S/sup 4/D) nMOSFET is demonstrated and its hot carrier reliability is investigated for the first time. This S/sup 4/D nMOSFET exhibited high drain current and well-suppressed short channel effects concurrently. In spite of the impact ionization rate issue, the S/sup 4/D structure offers a major improvement in current and transconductance degradations as compared with the LDD structure. The mechanism of the improved hot carrier reliability is explained using a two-dimensional (2-D) simulation.
La migración femenina en la región centro del estado de Coahuila como consecuencia de la reconversión de altos hornos de México, s. A. B. De c. V. (2013)

The differences in macroeconomic policies, migration, changes in the process of financial liberalization, and its effect on the financial crisis of the 1990s, the Altos Hornos de Mexico, S.A B. de C. V. has effect on female migration in the central region of the State of Coahuila. Interviews to migrant women, in the cities of San Antonio, Waco, and Austin, Texas, shows that they are inserted into markets precarious and low paid. The short time they devote to their children negatively affecting his training is worrying. 1
Relationship between the chemical and sensory properties of exotic salad crops—coloured lettuce (lactuca sativa) and chicory (cichorium intybus) (1990)

Abstract Samples of red‐coloured lettuce and chicory were assessed for bitterness by sensory analysis and compared with conventional green‐coloured varieties. The amounts of the sesquiterpene lactones lactucin, 8‐deoxylactucin and lactucopicrin and their glycosides were determined using enzyme hydrolysis and high performance liquid chromatography. The level of each of these compounds was compared with the bitterness score found for each sample, and the resulting correlation data suggested that the increasing level of one of these compounds, lactucin glycoside, was closely related to the increase in bitterness.
The Preparation of Uranium Tetrachloride (1973)

Abstract This communication describes a method of preparing UCl4, based on the interaction of UO2 with CCl4, that is satisfactory for laboratory scale preparations.
Functions of prostaglandins. (1972)

Prostaglandins are naturally occurring compounds which are easily separable from other biologically active substances because of its acidic lipid nature. They are divided into 4 series, the A, B, E, and Falpha series, which differ in the structure of the characteristic 5-membered ring. Prostaglandins play a role in the following reproductive functions: 1) conception; 2) luteolysis; 3) menstruation; and 4) parturition. It has also been proposed that Prostaglandin A may be the natriuretic hormone, the circulating hormone which controls sodium reabsorption by the kidney. The experiments of Lee and Ferguson in which prostaglandins inhibited PAH uptake by rabbit renal cortex slices in vitro support this view. Prostaglandins are also implicated 1) in the fluid transfer in the gut; 2) as causative agents of diarrhea that accompanies medullary carcinoma of the thyroid or neural crest tumors; 3) in reducing blood pressure in humans with essential hypertension; 4) in fatty acid metabolism, including lipolysis; and 5) as mediators of the inflammatory response. Further research in prostaglandins will establish the validity of the proposed physiologic or pathologic functions of prostaglandins.
Monolithically integrated 4×4 InGaAsP/InP laser amplifier gate switch arrays (2002)

This paper describes the mask layout of a tree-structured strictly nonblocking 4/spl times/4 gate switch array. 16 amplifier gates are used in the interconnection region to control the switch state and four booster amplifiers are included just after the inputs and just before the outputs. The switches are fabricated in the InGaAsP/InP material system, and the fabrication process is based on metal-organic vapour-phase epitaxy (MOVPE) and reactive ion etching (RIE) to form the waveguide mesa; selective wet chemical etching is used to define the active sections in the direction of light propagation. Regrowth is performed in two steps by MOVPE: firstly, iron doped semi-insulating and n doped current blocking layers are selectively grown, and secondly, the contact layers are grown. To laterally isolate the active sections from each other, the contact layers outside the contacts are removed by RIE. Antireflective coatings are applied to the cleaved chips to reduce the optical feedback and for improved coupling efficiency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis and properties of 4'-ThioDNA: unexpected RNA-like behavior of 4'-ThioDNA (2006)

The synthesis and properties of fully modified 4'-thioDNAs, oligonucleotides consisting of 2'-deoxy-4'-thionucleosides, were examined. In addition to the known literature properties (preferable hybridization with RNA and resistance to endonuclease hydrolysis), we also observed higher resistance of 4'-thioDNA to 3'-exonuclease cleavage. Furthermore, we found that fully modified 4'-thioDNAs behaved like RNA molecules in their hybridization properties and structural aspect, at least in the case of the 4'-thioDNA duplex. This observation was confirmed by experiments using groove binders, in which a 4'-thioDNA duplex interacts with an RNA major groove binder, lividomycin A, but not with DNA groove binders, to give an increase in its thermal stability. Since a 4'-thioDNA duplex competitively inhibited the hydrolysis of an RNA duplex by RNase V1, it was not only the physical properties but also this biological data suggested that a 4'-thioDNA duplex has an RNA-like structure.
Metabolism of 3-chloro-, 4-chloro-, and 3,5-dichlorobenzoate by a pseudomonad (1979)

Pseudomonas sp. WR912 was isolated by continuous enrichment in three steps with 3-chloro-, 4-chloro-, and finally 3,5-dichlorobenzoate as sole source of carbon and energy. The doubling times of the pure culture with these growth substrates were 2.6, 3.3, and 5.2 h, respectively. Stoichiometric amounts of chloride were eliminated during growth. Oxygen uptake rates with chlorinated benzoates revealed low stereospecificity of the initial benzoate 1,2-dioxygenation. Dihydrodi-hydroxybenzoate dehydrogenase, catechol 1,2-dixoygenase, and muconate cycloisomerase activities were found in cell-free extracts. The ortho cleavage activity for catechols appeared to involve induction of isoenzymes with different stereospecificity towards chlorocatechols. A catabolic pathway for chlorocatechols was proposed on the basis of similarity to chlorophenoxyacetate catabolism, and cometabolism of 3,5-dimethylbenzoate by chlorobenzoate-induced cells yielded 2,5-dihydro-2,4-dimethyl-5-oxo-furan-2-acetic acid.
Trial Publication after Registration in ClinicalTrials.Gov: A Cross-Sectional Analysis (2009)

Reporting of optional data elements varied and publication rates among completed trials registered within ClinicalTrials.gov were low. Without greater attention to reporting of all data elements, the potential for ClinicalTrials.gov to address selective publication of clinical trials will be limited. Please see later in the article for the Editors' Summary.
Local covariance equalization of hyperspectral imagery: advantages and limitations for target detection (2005)

The operational implementation of many conventional hyperspectral detection algorithms can be greatly simplified by adaptively preprocessing all test pixels and target signatures to equalize first- and second-order background statistics. The process is equivalent to expressing spectral radiance in a locally Euclidean coordinate system. Removing hyperspectral curvature in this way greatly simplifies both the data archiving function and the mathematical forms of standard detectors. Here we show why the equalization procedure does not compromise performance for conventional detection methods. More advanced algorithms cannot, however, be implemented with equalized data alone. We show how this limitation can nonetheless be overcome by temporarily storing a few parameters, with no archiving penalty