gebhart/patrepeval huggingface dataset:
A Role for Sp1 in the Transcriptional Regulation of Hepatic Triacylglycerol Hydrolase in the Mouse (2001)

Microsomal triacylglycerol hydrolase (TGH) hydrolyzes stored triacylglycerol in cultured hepatoma cells (Lehner, R., and Vance, D. E. (1999) Biochem. J. 343, 1-10). We studied expression of TGH in murine liver and found both protein and mRNA increased dramatically at 27 days after birth. Nuclear run-on assays demonstrated that this was due to increased transcription. We cloned 542 base pairs upstream of the transcriptional start site of the murine TGH gene. Electrophoretic mobility shift assays demonstrated enhanced binding of hepatic nuclear proteins from 27-day-old mice to the murine TGH promoter, yielding three differentially migrating complexes. DNase I footprint analysis localized these complexes to two distinct regions: site A contains a putative Sp binding site, and site B contains a degenerate E box. We transfected primary murine hepatocytes with a series of 5'-deletion constructs upstream of the reporter luciferase cDNA. Positive control elements were identified in a segment containing site A. Competitive electrophoretic mobility shift assays and supershift assays demonstrated that site A binds Sp1 and Sp3. Transcriptional activation assays in Schneider SL-2 insect cells demonstrated that Sp1 is a potent activator of the TGH promoter. These experiments directly link increased TGH expression at the time of weaning to transcriptional regulation by Sp1.
Catalyst Sintering and Reactor Design (1983)

Abstract The subject of sintering (sometimes termed coarsening) has received considerable attention since the late 1960s, and a review [1] appeared in this journal in 1975. Significant progress has been made since then, in particular, with regard to the mechanisms and kinetics of sintering and measurement techniques. With these advances it is now possible to utilize the understanding gained for the design of reactors undergoing catalyst sintering. In fact, a few attempts have already been made.
[Double-stranded RNA from phage F6: its interferon-inducing and antiviral properties]. (1990)

Double stranded RNA was isolated from bacteriophage phi 6 parasitizing on phytobacteria. Its interferon-inducing and antiviral activities were shown in vitro and in vivo. In the culture of L-929 cells, interferon resistant to heat and acids was synthesized. The interferon could be practically completely neutralized by specific anti-interferon serum. The phage phi 6 preparation dsRNA in the lyophilized form was studied. The preparation retained its biological activity. It was shown that a preparation containing 30 per cent of dsRNA was less toxic than a preparation containing 100 per cent of dsRNA, the difference in the interferon-inducing activity being insignificant.
Compressive Behaviors of 3-D Additive Manufactured Shock Absorption Material (2019)

This paper addresses shock absorption behavior of 3-D additive manufactured truncated octahedron for the landing gear of lunar and planetary explores. The deformation modes of truncated octahedron were predicted by the form finding analyses. The collapse load of each deformation load was calculated by the plastic hinge theory. The predicted load--displacement curve agreed with the experimental results, and thus, the proposed prediction method was verified.
Extraction of information from laser-induced breakdown spectroscopy spectral data by multivariate analysis (2008)

Laser-induced breakdown spectroscopy (LIBS) is being proposed more and more as a high-throughput technology to assess the elemental composition of materials. When a specific element is of interest, semiquantification is possible by building a calibration model using the emission line intensity of this element for known samples. However, a unique element has usually more than one emission line, and there are many examples where several emission lines used in combination give dramatically better results than any of the individual variables used alone. With a multivariate approach, models can be constructed that take into account all the emission lines related to a specific element; therefore more robust models can be developed. In this work, chemometric methods such as principal component analysis and partial least squares are proposed to resolve and extract useful information from the LIBS spectral data collected on biological materials.
Incomplete glycosylation and defective intracellular targeting of mutant solute carrier family 11 member 1 (Slc11a1) (2004)

Solute carrier family 11 member 1 (Slc11a1, formerly Nramp1) is a highly glycosylated, 12 transmembrane domain protein expressed in macrophages. It resides in the membrane of late endosomes and lysosomes, where it functions as a bivalent cation transporter. Mice susceptible to infection by various intracellular pathogens including Leishmania donovani and Salmonella typhimurium carry a glycine to aspartic acid substitution at position 169 (G169D, Gly(169)-->Asp), within transmembrane domain 4 of Slc11a1. To investigate the molecular pathogenesis of infectious disease susceptibility, we compared the behaviour of heterologously and endogenously expressed wild-type and mutant Slc11a1 by immunofluorescence, immunoelectron microscopy and Western-blot analysis. We found occasional late endosome/lysosome staining of mutant protein using immunoelectron microscopy, but most of the mutant Slc11a1 was retained within the ER (endoplasmic reticulum). Using glycosylation as a marker for protein maturation in two independent heterologous expression systems, we found that most mutant Slc11a1 existed as an ER-dependent, partially glycosylated intermediate species. Correct endosomal targeting of wild-type Slc11a1 continued despite disruption of N-glycosylation sites, indicating that glycosylation did not influence folding or sorting. We propose that the G169D mutation causes localized misfolding of Slc11a1, resulting in its retention in the ER and manifestation of the loss of function phenotype.
Phosphatidylglycerol biosynthesis in chloroplasts of Arabidopsis mutants deficient in acyl‐ACP glycerol‐3‐ phosphate acyltransferase (2006)

The biosynthesis of phosphatidylglycerol represents a central pathway in lipid metabolism in all organisms. The enzyme catalyzing the first reaction of the pathway in the plastid, glycerol-3-phosphate acyl-acyl carrier protein acyltransferase, is thought to be encoded in Arabidopsis by the ATS1 locus. A number of genetic mutants deficient in this activity have been described. However, the corresponding mutant alleles have not yet been analyzed at the molecular level and a causal relationship between the mutant phenotypes and a deficiency at the ATS1 locus has not been established. The presence in all known ats1 mutants of near wild-type amounts of phosphatidylglycerol raised the question of whether an alternative pathway of phosphatidylglycerol assembly in the plastid exists. However, detailed analysis of several independent ats1 mutant alleles revealed that all are leaky. Reduction by RNAi of ats1-1 RNA levels in the ats1-1 mutant background led to a more severe growth phenotype (small green plants and reduced seed set), but did not decrease the relative amount of phosphatidylglycerol. In contrast, when the amount of ATS2 mRNA encoding the plastidic lysophosphatidic acid acyltransferase catalyzing the second reaction of the pathway was reduced by RNAi in the ats1-1 mutant background, phosphatidylglycerol amounts decreased, leading to a growth phenotype (small pale-yellow plants) that is reminiscent of the pgp1-1 mutant deficient in a late step of plastidic phosphatidylglycerol biosynthesis. These observations indicate coordinated regulation of plastid lipid metabolism and plant development.
Sur l'unicité des solutions de l'équation d'abel-schröder et l'itération continue (1965)

Soit f ( x ) continue strictement croissante pour x ∈ [0, a 0 ] et telle que 0 < f(x) < x pour x ∈ 0, a 0 ]. Il est connu que l'équation fonctionnelle d'Abel ainsi que l'équation de Schröder possèdent une infinité de solutions continues strictement croissantes.
Structural similarity metrics for texture analysis and retrieval (2009)

The development of objective texture similarity metrics for image analysis applications differs from that of traditional image quality metrics because substantial point-by-point deviations are possible for textures that according to human judgment are essentially identical. Thus, structural similarity metrics (SSIM) attempt to incorporate ¿structural¿ information in image comparisons. The recently proposed structural texture similarity metric (STSIM) relies entirely on local image statistics. We extend this idea further by including a broader set of local image statistics, basing the selection on metric performance as compared to subjective evaluations. We utilize both intra- and inter-subband correlations, and also incorporate information about the color composition of the textures into the similarity metrics. The performance of the proposed metrics is compared to PSNR, SSIM, and STSIM on the basis of subjective evaluations using a carefully selected set of 50 texture pairs.
Electro-optic longitudinal electron beam diagnostic at SDL (2004)

The linac at the NSLS Source Development Lab (SDL) provides a high brightness electron beam for the DUV-FEL project with subpicosecond bunch length and several hundred Amperes peak current by means of a photoinjector and a magnetic bunch compressor. Previous diagnostics of the longitudinal bunch dynamics relied on the rf zero-phasing method and measurements of CTR spectra. In order to have a fast and nonintercepting longitudinal diagnostic available, the electro-optic measurement technique has been implemented with its major component, a synchronized 100 fs Ti:sapphire laser coaligned with the electron beam, already in place as a seed for the FEL. The theoretical temporal resolution for a 100 /spl mu/m thick ZnTe crystal is limited to about 200 fs and the signal contrast to more than 1%. We present preliminary results of multishot scanning measurements and the single-shot diagnostics of the bunch shape as well as its application as a rf-laser jitter monitor.
Elasticity of macroscopic isotropic media applied to nano--cantilevers (2006)

We analyze recently measured data for the mechanical deflection of Chromium nano--cantilevers. We show that the deflection curves exhibit a scaling behavior when applying properly chosen coordinates. Moreover, the deflection curves are well described by Euler's theory for elastic, macroscopic rods made of homogenous material. Apart from the conceptual insight, this also yields a precise method to deduce the Young's modulus of these nano--cantilevers. It is found to be considerably smaller than that of a macroscopic Chromium rod.
ChemInform Abstract: Use of Rhodium Nanoparticles in Hydrogenation and Hydroformylation Reactions (2013)

Abstract Review: 158 refs.
Primary Lithium Organic Electrolyte Battery BA-5588. (1982)

This program concerns the development, fabrication and evaluation of a Lithium-Organic Electrolyte Battery designated BA 5588 ()/U which incorporates five (5) series connected, hermetically sealed cells housed in a plastic case. Significant effort was directed towards cell optimization through controlled experimentation and evaluation of various design parameters. Demonstration of the effectiveness of the finalized design was accomplished by the performance of various electrical and abuse tests which included environmental exposure, prolonged thermal storage, electrical discharge under various thermal profiles, short circuit and discharge to zero volts as well as forced discharge. The resulting evaluation demonstrated the batteries ability to operate safely under all of the specified abusive environments and provide 100% of the specified service life requirements. (Author)
Single- and double-negative refractive indices of combined metamaterial structure (2009)

We experimentally and numerically studied the transmission spectra of a combined metamaterial structure whose negative refractive index was supposed to be achievable only with simultaneously negative permittivity and permeability. However, it was found that the negativity of the refractive index of such a structure could be obtained not only when both parameters were negative but also when only one parameter, more specifically the permittivity was negative. These characteristics of combined structure were analyzed in detail by using the standard retrieval effective-medium method. According to the analyses, it can be concluded that the negativity originates from the complex permittivity and permeability. The interplay among the real and the imaginary parts of those parameters is the key to the negative behavior of refractive index.
Faster WCET flow analysis by program slicing (2006)

Static Worst-Case Execution Time (WCET) analysis is a technique to derive upper bounds for the execution times of programs. Such bounds are crucial when designing and verifying real-time systems. WCET analysis needs a program flow analysis to derive constraints on the possible execution paths of the analysed program, like iteration bounds for loops and dependences between conditionals.Current WCET analysis tools typically obtain flow information through manual annotations. Better support for automatic flow analysis would eliminate much of the need for this laborious work. However, to automatically derive high-quality flow information is hard, and solution techniques with large time and space complexity are often required.In this paper we describe how to use program slicing to reduce the computational need of flow analysis methods. The slicing identifes statements and variables which are guaranteed not to influence the program flow. When these are removed, the calculation time of our different flow analyses decreases, in some cases considerably.We also show how program slicing can be used to identify the input variables and globals that control the outcome of a particular loop or conditional. This should be valuable aid when performing WCET analysis and systematic testing of large and complex real-time programs.
Visualization and Explanation of Payload-Based Anomaly Detection (2009)

The threat posed by modern network attacks requires novel means for detection of intrusions, as regular signature-based systems fail to cope with the amount and diversity of attacks. Recently, several methods for detection of anomalies in network payloads have been proposed to counteract this threat and identify novel attacks during their initial propagation. However, intrusion detection systems must not only flag malicious events but also provide information needed for assessment of security incidents. Previous work on payload-based anomaly detection has largely ignored this need for explainable decisions. In this paper, we present instruments for visualization and explanation of anomaly detection which can guide the decisions of a security operator. In particular, we propose two techniques: feature differences, for identifying relevant string features of detected anomalies, and feature shading, for highlighting of anomalous contents in network payloads. Both techniques are empirically evaluated using real attacks and network traces, whereby their ability to emphasize typical patterns of attacks is demonstrated.
High-frame-rate, high-resolution Cinematographic Particle Image Velocimetry (1997)

We present our progress in the development of a high-frame-rate, high-resolution Cinematographic Particle Image Velocimetry (CPIV) system, addressing the development of hardware as well as image processing algorithms. A rotating prism, 16mm film camera is used with frame rates up to 10,000 fps and equivalent pixel resolution of each frame, on the order of 1400 x 1000. A computerized digitization station for automated digitization of entire film rolls was developed. For flow illumination, a high power, noncoherent illumination system was implemented. In terms of image processing algorithms, new techniques are proposed with improved spatial resolution and reliability over existing methods. Emphasis is placed on a new wavelet-based cross-correlation approach. Finally, hardware and software performance are demonstrated via sample water tunnel experiments. (Author)
Electrical modeling of myocardium and development of advanced pacing techniques (1998)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1998.
Mesomorphic Thermal Stability of 3-(4-Alkoxybenzylideneamino)-dibenzofurans and 3-(4-Alkoxybenzylideneamino)-dibenzothiophenes (1986)

Abstract The homologous series of two kinds of heteroaromatic liquid crystals (I,X=-O-and -S-) were prepared and their mesomorphic thermal stabilities were investigated. Some factors determining the stability were examined and the results indicate that the bridging atom (X) incorporated in the structure (I) significantly affects the mesomorphic thermal stability.
Stereoselective Alkyne Hydrogenation by using a Simple Iron Catalyst (2019)

The stereoselective hydrogenation of alkynes constitutes one of the key approaches for the construction of stereodefined alkenes. The majority of conventional methods utilize noble and toxic metal catalysts. This study concerns a simple catalyst comprised of the commercial chemicals iron(II) acetylacetonate and diisobutylaluminum hydride, which enables the Z-selective semihydrogenation of alkynes under near ambient conditions (1-3 bar H<sub>2</sub> , 30 °C, 5 mol % [Fe]). Neither an elaborate catalyst preparation nor addition of ligands is required. Mechanistic studies (kinetic poisoning, X-ray absorption spectroscopy, TEM) strongly indicate the operation of small iron clusters and particle catalysts.
THE SCHOOL LUNCH AS A SUPPLEMENT TO THE HOME DIET OF GRADE SCHOOL CHILDREN1 (1940)

Interest is general in the possibility of improving the nutritional status of grade-school children by mid-day or mid-session feeding at school. For this reason, the study described in this report was conducted to find whether or not it might be possible to supplement the morning and evening home meals of representative children in different socio-economic groups in such a way as to bring the day's intake up to a desirable standard.
Quinuclidine and DABCO Enhance the Radiofluorination of 5‐Substituted 2‐Halopyridines (2017)

Positron emission tomography (PET) is an important molecular imaging technique for medical diagnosis, biomedical research and drug development. PET tracers for molecular imaging contain β<sup>+</sup>-emitting radionuclides, such as carbon-11 (<i>t</i><sub>1/2</sub> = 20.4 min) or fluorine-18 (<i>t</i><sub>1/2</sub> = 109.8 min). The [<sup>18</sup>F]2-fluoro-pyridyl moiety features in a few prominent PET radiotracers, not least because this moiety is usually resistant to unwanted radiodefluorination in vivo. Various methods have been developed for labeling these radiotracers from cyclotron-produced no-carrier-added [<sup>18</sup>F]fluoride ion, mainly based on substitution of a leaving group, such as halide (Cl or Br), or preferably a better leaving group, such as nitro or trimethylammonium. However, precursors with a good leaving group are sometimes more challenging or lengthy to prepare. Methods for enhancing the reactivity of more readily accessible 2-halopyridyl precursors are therefore desirable, especially for early radiotracer screening programs that may require the quick labeling of several homologous radiotracer candidates. In this work, we explored a wide range of additives for beneficial effect on nucleophilic substitution by [<sup>18</sup>F]fluoride ion in 5-subsituted 2-halopyridines (halo = Cl or Br). The nucleophilic cyclic tertiary amines, quinuclidine and DABCO, proved effective for increasing yields to practically useful levels (> 15%). Quinuclidine and DABCO likely promote radiofluorination through reversible formation of quaternary ammonium intermediates.
Synthesis, crystal structures, Moessbauer, susceptibility, and EPR studies of a series of spin exchange coupled complexes containing the (.mu.-oxo)bis(.mu.-acetato)rutheniummetal core and its hydroxo-bridged analog (metal = vanadium, chromium, manganese, iron, cobalt) (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, crystal structures, Moessbauer, susceptibility, and EPR studies of a series of spin exchange coupled complexes containing the (.mu.-oxo)bis(.mu.-acetato)rutheniummetal core and its hydroxo-bridged analog (metal = vanadium, chromium, manganese, iron, cobalt)Rainer Hotzelmann, Karl Wieghardt, Juergen Ensling, Harald Romstedt, Philipp Guetlich, Eckhard Bill, Ulrich Floerke, and Hans Juergen HauptCite this: J. Am. Chem. Soc. 1992, 114, 24, 9470–9483Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ja00050a028https://doi.org/10.1021/ja00050a028research-articleACS PublicationsRequest reuse permissionsArticle Views528Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis of dual functional pyrimidinium ionic liquids as reaction media and antimicrobial agents (2016)

This article describes a two-step synthesis of twenty<italic>N</italic>-alkyl pyrimidinium ionic liquids through<italic>N</italic>-alkylation of pyrimidine with<italic>n</italic>-alkyl (C<sub>1</sub>–C<sub>10</sub>) halides followed by anion metathesis and their dual applications as reaction media and antibacterial agents.
A Process in Need Is a Process Indeed: Scalable Enantioselective Synthesis of Chiral Compounds for the Pharmaceutical Industry. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
White-light generation with sub-ps pulses (2015)

We generate white light supercontinuum from slightly sub-picosecond pulses at 1.03 µm and 515 nm. We compare the spectra and stability for various crystals, focusing conditions and pulse durations, and determine the best parameters for sub-picosecond driver pulse duration. Comparing the experimental observations with the theory of white-light generation from Brodeur and Chin, it appears that in this particular range of pump pulse duration, two mechanisms interact and prevent a catastrophic collapse of the beam: multi-photon excitation (typical for ~100-fs-long pulses) and avalanche ionization (typical for >1-ps pulses). The two processes both manifest themselves in different experimental observations.
Bilateral Cotton Wool Spots After Use of an Endothelin Receptor Antagonist (2014)

Ambrisentan (Letairis; Gilead Sciences, Foster City, CA) is an endothelin receptor antagonist approved by the U.S. Food and Drug Administration for the treatment of pulmonary arterial hypertension. The authors describe the occurrence of bilateral cotton wool spots soon after initiation of ambrisentan treatment in a 29-year-old woman. Fluorescein angiography, optical coherence tomography, and fundus autofluorescence were performed. After discontinuation of ambrisentan, the cotton wool spots resolved without recurrence. To the authors' knowledge, this is the first report of retinopathy in the form of cotton wool spots associated with the use of an endothelin receptor antagonist.