gebhart/patrepeval huggingface dataset:
Dose pre-hospital laryngeal mask airway use has a survival benefit in non-shockable cardiac arrest? (2014)

Background. Whether pre-hospital laryngeal mask airway (LMA) use poses a survival benefit and should be approved as routine airway management in non-shockable cardiac arrest is of major concern. The present study examined the effective-ness of LMA, in comparison to other pre-hospital airway management on individuals who have experienced non-shockable cardiac arrest. Methods. Adult patients who experienced non-shockable cardiac arrest with activation of the emergency medical service (EMS) made up our study cohort in Taoyuan, Taiwan. The data were abstracted from EMS records and cardiac arrest regi-stration protocols. Results. Among the 1912 enrolled patients, most received LMA insertion (72.4%), 108 (5.6%) bag-valve-mask (BVM) venti-lation, 376 (19.7%) high-flow oxygen non-rebreather facemask, and only 44 (2.3%) received endotracheal tube intubation (ETI). With regard to survival to discharge, no significant differences in prevalence were evident among the groups: 2.8% of oxygen facial mask, 1.1% of BVM, 2.1% of LMA, and 4.5% of the ETI group survived to discharge (p = 0.314). In comparison to oxygen facial mask use, different types of airway management remained unassociated with survival to discharge after adjusting for variables by logistic regression analysis (BVM: 95% confidence interval [CI], 0.079 – 1.639 [p = 0.186]; LMA: 95% CI, 0.220–2.487 [p = 0.627]; ETI: 95% CI, 0.325–17.820 [p = 0.390]). The results of Hosmer-Lemeshow goodness-of-fit test of logistic regression model revealed good calibration.Conclusions. Pre-hospital LMA use was not associated with additional survival to discharge compared with facial oxygen mask, BVM, or ETI following non-shockable cardiac arrest.
ChemInform Abstract: Novel Thymidine Analogues via Reaction of Unprotected 5′‐Deoxy‐5′‐ iodothymidine with Dianions. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Two distinct cytoplasmic regions of the β2 integrin chain regulate RhoA function during phagocytosis (2006)

AlphaMbeta2 integrins mediate phagocytosis of opsonized particles in a process controlled by RhoA, Rho kinase, myosin II, Arp2/3, and actin polymerization. AlphaMbeta2, Rho, Arp2/3, and F-actin accumulate underneath bound particles; however, the mechanism regulating Rho function during alphaMbeta2-mediated phagocytosis is poorly understood. We report that the binding of C3bi-opsonized sheep red blood cells (RBCs) to alphaMbeta2 increases Rho-GTP, but not Rac-GTP, levels. Deletion of the cytoplasmic domain of beta2, but not of alphaM, abolished Rho recruitment and activation, as well as phagocytic uptake. Interestingly, a 16-amino acid (aa) region in the membrane-proximal half of the beta2 cytoplasmic domain was necessary for activating Rho. Three COOH-terminal residues (aa 758-760) were essential for beta2-induced accumulation of Rho at complement receptor 3 (CR3) phagosomes. Activation of Rho was necessary, but not sufficient, for its stable recruitment underneath bound particles or for uptake. However, recruitment of active Rho was sufficient for phagocytosis. Our data shed light on the mechanism of outside-in signaling, from ligated integrins to the activation of Rho GTPase signaling.
Lattice models of branched polymers: dynamics of uniform stars (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLattice models of branched polymers: dynamics of uniform starsM. K. Wilkinson, D. S. Gaunt, J. E. G. Lipson, and S. G. WhittingtonCite this: Macromolecules 1988, 21, 6, 1818–1822Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ma00184a048https://doi.org/10.1021/ma00184a048research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Preoperative hyperthermia combined with radiotherapy and chemotherapy for patients with incompletely resected carcinoma of the esophagus (1988)

Two hundred eighty-nine patients with squamous cell carcinoma of the esophagus underwent subtotal esophagectomy from December 1965 to June 1986. Resection of esophageal carcinoma was absolutely noncurative in 64 patients (20%) due to invasion to the surrounding structures. These 64 patients were subdivided as follows into three groups based on the type of preoperative treatment: Group I included 16 patients without preoperative treatment; Group II included 38 patients with preoperative radiotherapy combined with chemotherapy (average doses: radiation 37.3 Gy, 1-(2-tetrahydrofuryl)-5-fluorouracil [tegafur] 8.4 g); Group III included 10 patients who underwent preoperative hyperthermia (42 degrees C to 45 degrees C) combined with chemotherapy and radiotherapy (average doses: radiation 33 Gy, bleomycin 33.9 mg, or cis-diamine dichloroplatinum 75 mg, hyperthermia 6.2 times). There were no significant differences in terms of postoperative therapy among the three groups. The median survival times for patients in Groups I, II, and III were 6, 7.5 and 11 months, respectively. The 2-year survival rates for patients in Groups I, II, and III were 0, 15.6%, and 34.3%, respectively. The prognosis in Group III was superior to that for Group I (P less than 0.05) and Group II. These results suggest that preoperative hyperthermia combined with radiotherapy and chemotherapy could prolong survival even in patients who have had noncurative resection.
Strain Contrast of Coherent Precipitates in Cu-Co Alloys under Excitation of High Order Reflections (1985)

Journal Article Strain Contrast of Coherent Precipitates in Cu-Co Alloys under Excitation of High Order Reflections Get access Yoshitsugu TOMOKIYO, Yoshitsugu TOMOKIYO *HVEM Lab., Kyushu UniversityFukuoka, 812 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Sho MATSUMURAS, Sho MATSUMURAS **Department of Materials Science and Technology, Graduate Engineering Sciences, Kyushu UniversityKasuga, 816 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Masumitsu TOYOHARA Masumitsu TOYOHARA ***Nippon Atomic Industry Group Co., Ltd.Kawasaki, 210 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Electron Microscopy, Volume 34, Issue 4, December 1985, Pages 338–346, https://doi.org/10.1093/oxfordjournals.jmicro.a050526 Published: 01 December 1985 Article history Published: 01 December 1985 Received: 27 January 1986 Accepted: 22 February 1986
Surgical Treatment of Postoperative Deltoid Origin Disruption (1997)

Although it is well recognized that deltoid disruption after shoulder surgery is associated with poor function, little information is available regarding results of surgical treatment for this problem. Twenty-four patients underwent direct repair or rotational deltoidplasty reconstruction of a detached muscle origin after shoulder surgery. The original surgical procedure was rotator cuff repair in 12, acromioplasty in four, and lateral acromionectomy with or without rotator cuff repair in eight. The average duration of symptoms before deltoid reconstruction was 17 months. The mean followup was 39 months (range, 13-84 months). Twelve patients reported moderate to severe pain, whereas 12 had minimal pain. Two patients required a shoulder fusion for intractable pain. Overall, one (4%) excellent, seven (29%) good, and 16 (67%) unsatisfactory results were observed. A poor outcome was associated with a prior lateral acromionectomy, involvement of the middle deltoid, a massive rotator cuff tear with weakness in external rotation, and a residual postoperative defect larger than 2 cm. In select cases, repair or deltoidplasty can improve function and pain.
Properties and scopes in web model checking (2005)

We consider a formal framework for property verification of web applications using Spin model checker. Some of the web related properties concern all states of the model, while others - only a proper subset of them. To be able to discriminate states of interest in the state space, we solve the problem of property specification in LTL over a subset of states of a system under test while ignoring the valuation of the properties in the rest of them. We introduce specialized operators that facilitate specifying properties over propositional scopes, where each scope constitutes a subset of states that satisfy a propositional logic formula. Using the proposed operators, the user can specify web properties more concisely and intuitively. We illustrate the proposed solution in specifying properties of web applications and discuss other potential applications.
<sup>31</sup>P-NMR study of cardiac preservation: St. Thomas' Hospital cardioplegic solution versus UW preservation solution (1991)

Abstract. Ex vivo cardiac preservation was evaluated by measuring the catabolism of high-energy phosphate (ATP and creatine phosphate, CrP) using 31P-NMR spectroscopy. After cardioplegic arrest St. Thomas' Hospital cardioplegic solution (group A), and University of Wisconsin (UW) preservation solution (group B) were tested. The hearts were mounted in the 4.7 T horizontal bore magnet of the NMR spectrometer and were continuously perfused with the test solution under 25 cm H2O pressure for 6 h at 10°C. Peak heights of the β-phosphate of ATP and CrP were measured and expressed as percentages of the initial value. For both group A and group B, ATP declined less rapidly during preservation than CrP. In group A, ATP remained constant for 60 min while CrP decreased from the onset of preservation. After 6 h of preservation 28.3% of ATP and 24.5% of CrP remained (group A). On the other hand, in group B, levels of both ATP and CrP remained much more stable: CrP did not decrease during the first 3 h of preservation, while ATP started to decrease after 5 h. At the end of preservation 76.1% of ATP and 71.5% of CrP were still present. We conclude that UW solution is superior to St. Thomas' Hospital solution for the preservation of high-energy phosphates during 6 h cardiac preservation with continuous hypothermic low-flow perfusion.
ChemInform Abstract: ASYMMETRIC MICHAEL ADDITIONS. PRACTICALLY COMPLETELY DIASTEREO‐ AND ENANTIOSELECTIVE ALKYLATIONS OF THE ENAMINE FROM CYCLOHEXANONE AND PROLINYL METHYL ETHER BY Ω‐NITROSTYRENES TO GIVE U‐2‐(1′‐ARYL‐2′‐NITROETHYL)CYCLOHEXANONES (1982)

Abstract Bei der Umsetzung des (S)‐Enamins (I) [N‐(1′‐Cyclohexenyl)‐prolinylmethylether] mit den Nitroethylenen (II) entsteht jeweils nur 1 der möglichen diastereomeren Addukte; nachfolgende Hy‐ 24 drolyse gibt die Titelverbindungen (III).
Status and Future Plans of the PEP-II B-Factory (2002)

The PEP-II e+e-collider has been operating for two years with the BaBar detector at the energy of the Upsilon 4S resonance. The peak luminosity has reached 3.3 Ã1033/cm2/s with 693 bunches with a positron current of 1.5 A and an electron current of 0.8 A. PEP-II has delivered in excess of 38 fb-1of data to BaBar. The beam-beam tune shift limits are approaching 0.05-0.07 horizontally and 0.03-0.05 vertically. The electron cloud instability ECI enlarges the positron beam size at high currents but is reduced by a solenoidal field on the vacuum chambers. The beam currents in PEP-II are being raised to increase the number of bunches and the luminosity. Over the next few years the luminosity goal for PEP-II is 1034/cm2/s.
Depth control GRIN lens array for integral photography (2003)

This paper describes a new means to control depth positions of 3-D images for integral photography. A GRIN lens array is set in front of a lens array for image capturing. The length of each elemental GRIN lens composing the array is a half of one period of the optical path. The GRIN lens array also avoids pseudoscopic effects with revised depth. The depth position of the 3-D images is controlled by adjusting the distance between the GRIN lens array and the capturing lens array, thus producing 3-D images without depth distortion.
An efficient and mild oxidative amidation of aldehydes using B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> as a catalyst and biological evaluation of the products as potential antimicrobial agents (2017)

A mild and efficient protocol for oxidative amidation of diverse aldehydes with amines was developed to generate the corresponding amides in good to excellent yields.
Risk of Injury to Child Passengers in Compact Extended-Cab Pickup Trucks (2002)

Children in compact extended-cab pickup trucks are not as safe as children in other vehicles, primarily due to the increased relative risk of injury in the back seat. For families with another choice of vehicle, clinicians should advise parents against transporting children in compact pickup trucks. The current exemption for regulatory testing for occupant protection in the rear seats of compact pickup trucks should be reconsidered.
Hybrid Metamaterials for Solar Biofuel Generation (2014)

Abstract : We are creating a novel multifunctional solar biofuel generating platform by coupling designed protein charge separation constructs with newly developed photonic metamaterials -- metal/dielectric composites that control light in ways not possible with traditional optics. To accomplish this, we have assembled a team of laboratories who are each at the forefront of the new technologies necessary in its construction -- de novo protein design (Koder), nanoplasmonic metamaterials (Crouse) and protein film voltammetry (Elliott). We start with bio-inspired artificial protein domains designed to generate biofuels when modularly connected to enzyme domains directly derived from nature. The designed protein domain serves as a self-assembling 'smart matrix' incorporating synthetic zinc phthalocyanine (ZnPC) cofactors and porphyrins tailored for photon absorption, charge separation and directional charge/hole transfer. The designed charge separation domain will be benignly expressed in bacteria as a chimera with naturally occurring protein domains which utilize the high energy electrons supplied by the charge separation domain to generate biofuels. This domain will be attached to a novel metamaterial light harvesting template which traps and concentrates 95% of the light of a given wavelength into a cavity within a five wavelength radius. This solid state light harvesting device is thus over three orders of magnitude more effective than that found in green plants for light of 750 nm wavelength, the solar emission maximum. Furthermore, the properties of metamaterials open the door towards creating a multijunction device capable of separating white light into discrete wavelength ranges and trapping it efficiently into different, separately wired cavities. The protein-metamaterial contacts will be mediated by a novel click chemistry attachment strategy which utilizes in vivo incorporation of azidohomoalanine into the designed protein domain.
View Derivation Graph with Edge Fitting for Data Warehousing in Disconnected Environments (1999)

Data warehouse views cache summarized information from queries over one or multiple distributed base sources. In this paper, we address the problem of data warehouse maintenance in an environment where base source data can be stored on mobile devices. The requirements of a partially disconnected world lead to significant tradeoffs between the view update cost on one hand, and the level of freshness of the view on the other hand. Current decentralized maintenance methods that can be applied to a disconnected environment involve either replicating of source data at the view, or computing view updates through queries to all base sources. Replication may involve excessive storage overhead, while view update may be blocked due to the disconnection of any of the base sources. We propose a view maintenance approach that stores path information corresponding to data traditionally stored at the view, and offers several important advantages. From the maintenance point of view, our method reduces...
Cerebrospinal Fluid Ghrelin Is Negatively Associated with Body Mass Index (2003)

Ghrelin is a 28 amino acid peptide hormone, predominantly expressed in the gastric epithelium and, at a lower level, in the hypothalamus. Although several lines of evidence indicate that ghrelin has a role in appetite regulation, nevertheless the regulation and role of central ghrelin levels remain unclear. To further characterize the role of ghrelin in the regulation of body adiposity, we investigated the association between fasting cerebrospinal fluid (CSF) ghrelin levels and body mass index (BMI) in humans. We consecutively enrolled 19 adults (aged 21-76 yr, 15 females and 4 males), including 4 obese, 7 overweight and 8 lean subjects, who underwent spinal anesthesia during surgery for non-malignant conditions. We found a negative association between fasting CSF ghrelin levels and BMI (r = -0.48, p = 0.035) and a trend towards lower (by 16%) fasting CSF ghrelin levels in the obese (p = 0.06 for the difference between lean and obese subjects). In conclusion, we found a negative association between fasting CSF ghrelin levels and BMI in humans. Our data suggest that central ghrelin may have a role in the regulation of body adiposity in humans, which requires further study to be fully elucidated.
The Use of the Fluorogenic Synthetic Substrate Assay for the Clinical Determination of Heparin (1979)

Utilization of a new method (Ref. 1, Mitchell, et. al., Thrombosis Research, Vol. 13, pp. 47-52, 1978) recently described for the determination of heparin has been employed in clinical studies. The method was compared with accepted monitoring techniques such as the activated partial thromboplastin time determination. Subcutaneous, intermittent, and continuous infusion regimens of heparin were evaluated. Comparisons with the APTT results indicated excellent agreement between the two methods with the correlation coefficient of 0.79. Patients on combination of heparin + coumadin were able to be monitored with little or no interference by the synthetic substrate methodology. Continuous monitoring techniques, using the synthetic substrates technology indicated a high debtee of sensitivity and precision for this method.
Charge transport limited by grain boundaries in polycrystalline octithiophene thin film transistors (2002)

Organic filed-effect transistor (OFETs) based on polycrystalline “octithiophene” has been realized. The current-voltage characteristics at low drain voltage has been used to derive the mobility of organic field effects transistors (OFETs). It appears that the data must be corrected for the substantial source and drain contact resistance. The carrier mobility is found to increase quasi linearly with gate voltage at room temperature. The temperature dependent measurements show that the mobility is thermally activated and becomes practically temperature independent at low temperatures. A model based on trapping mechanism, in which it is assumed that charge transport is limited by grain boundaries, has been used to describe the carrier mobility in polycrystalline “octithiophene” thin film transistors measured at temperatures ranging from 10 K to 300 K.
Abstract IA13: Super-resolution fluorescence microscopy of cells and tissues (2012)

Abstract Light microscopy is an essential tool in biological research. However, the spatial resolution of light microscopy, classically limited by diffraction to a few hundred nanometers, is substantially larger than typical molecular length scales in cells. Hence many subcellular structures cannot be resolved by conventional light microscopy. We recently developed a new form of super-resolution fluorescence microscopy, stochastic optical reconstruction microscopy (STORM), that breaks the diffraction limit. STORM uses single-molecule imaging and photo-switchable fluorescent probes to temporally separate the spatially overlapping images of individual molecules. This approach allows the localization of fluorescent probes with nanometer precision and the construction of sub-diffraction-limit images. Using this method, we have achieved multicolor and three-dimensional (3-D) imaging of live cells and tissues with nanometer-scale resolution. In this talk, I will discuss the general concept, recent technological advances and biological applications of STORM. Citation Format: Xiaowei Zhuang. Super-resolution fluorescence microscopy of cells and tissues [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr IA13.
Plasma PTX3 protein levels inversely correlate with insulin secretion and obesity, whereas visceral adipose tissue PTX3 gene expression is increased in obesity (2011)

Plasma acutephase protein pentraxin 3 (PTX3) concentration is dysregulated in human obesity and metabolic syndrome. Here, we explore its relationship with insulin secretion and sensitivity, obesity markers, and adipose tissue PTX3 gene expression. Plasma PTX3 protein levels were analyzed in a cohort composed of 27 lean [body mass index (BMI) ≤ 25 kg/m(2)] and 48 overweight (BMI 25-30 kg/m(2)) men (cohort 1). In this cohort, plasma PTX3 was negatively correlated with fasting triglyceride levels and insulin secretion after intravenous and oral glucose administration. Plasma PTX3 protein and PTX3 gene expression in visceral (VAT) and subcutaneous (SAT) whole adipose tissue and adipocyte and stromovascular fractions were analyzed in cohort 2, which was composed of 19 lean, 28 overweight, and 15 obese subjects (BMI >30 kg/m(2)). An inverse association with body weight and waist/hip ratio was observed in cohort 2. In VAT depots, PTX3 mRNA levels were higher in subjects with BMI >25 kg/m(2) than in lean subjects, positively correlated with IL-1β mRNA levels, and higher in the adipocyte than stromovascular fraction. Human preadipocyte SGBS cell line was used to study PTX3 production in response to factors that obesity entails. In SGBS adipocytes, PTX3 gene expression was enhanced by IL-1β and TNFα but not IL-6 or insulin. In conclusion, the negative correlation between PTX3 and glucose-stimulated insulin secretion suggests a role for PTX3 in metabolic control. PTX3 gene expression is upregulated in VAT depots in obesity, despite lower plasma PTX3 protein, and by some proinflammatory cytokines in cultured adipocytes.