gebhart/patrepeval huggingface dataset:
Design of Experiment for Advanced Nanostructured WC-12Co Coating HVOF: Three-Point Bending Tests (2014)

Abstract In this study, a design of experiment (DOE) approach is used to investigate the influence of powder size and mixing ratio on the microstructure and properties of thermal spray coatings. Nano and micro sized WC-12Co powders combined in different proportions with Inconel 625 were deposited on carbon steel substrates by HVOF spraying. The resulting coatings are examined and the effect of different powder combinations on hardness and yield strength is assessed. Spraying procedures and test methods are described and the findings are discussed. Of the various coatings produced, one shows great promise for wear protection, particularly in oil and gas applications.
Beta 2-microglobulin amyloidosis: role of monocytes/macrophages (2002)

Beta 2-microglobulin amyloidosis arthropathies may result from progressive accumulation of advanced glycation end products in long-lived amyloid linked to a heightened cellular response. Antagonism of the interaction between advanced glycation end products and their receptor may be a relevant strategy for cellular inflammation in beta2-microglobulin amyloidosis.
Deep Subwavelength Wide‐Angle Structural Colors at the Single Pixel Level (2022)

Abstract Structural colorations with artificially engineered nanostructures provide a dye‐free mechanism for subdiffraction color generation with enhanced stability and environment friendliness. However, it remains elusive to create universally deep subwavelength pixels for arbitrary coloration at the single pixel level. The main obstacles are the unavoidable near‐field coupling between neighboring pixels and the angular dependent hues associated with the scattering process. Here, a generic principle is proposed and developed to create deep subwavelength bright‐field structural colors at the single pixel level by using alumina disk‐on‐film nanocavities. As a result of the gap‐plasmon‐induced perfect absorption, wide‐angle complementary colors are achieved across the full visible spectrum where both the near‐field coupling and angular dispersion are strongly suppressed. Deep subwavelength pixels down to 160 nm × 160 nm and green colors produced by composite pixels are experimentally demonstrated. The strategy represents a significant step toward practical application of structural colors at the single pixel level for nanoscale optical and optoelectronic devices.
Identification of a vacuolar proton channel that triggers the bioluminescent flash in dinoflagellates (2017)

In 1972, J. Woodland Hastings and colleagues predicted the existence of a proton selective channel (HV1) that opens in response to depolarizing voltage across the vacuole membrane of bioluminescent dinoflagellates and conducts protons into specialized luminescence compartments (scintillons), thereby causing a pH drop that triggers light emission. HV1 channels were subsequently identified and demonstrated to have important functions in a multitude of eukaryotic cells. Here we report a predicted protein from Lingulodinium polyedrum that displays hallmark properties of bona fide HV1, including time-dependent opening with depolarization, perfect proton selectivity, and characteristic ΔpH dependent gating. Western blotting and fluorescence confocal microscopy of isolated L. polyedrum scintillons immunostained with antibody to LpHV1 confirm LpHV1's predicted organellar location. Proteomics analysis demonstrates that isolated scintillon preparations contain peptides that map to LpHV1. Finally, Zn2+ inhibits both LpHV1 proton current and the acid-induced flash in isolated scintillons. These results implicate LpHV1 as the voltage gated proton channel that triggers bioluminescence in L. polyedrum, confirming Hastings' hypothesis. The same channel likely mediates the action potential that communicates the signal along the tonoplast to the scintillon.
Impact of patient weight on non-relapse mortality after marrow transplantation. (1995)

We hypothesized that severely overweight patients were at an increased risk of transplant-related toxicity and that this might be reflected in increased mortality soon after transplant. All patients transplanted between January 1985 and January 1992 were included in the analysis; data were complete for 2238 (1662 adults, 576 children ( > 18 years). Since we were interested primarily in acute post-transplant toxicity, survival through day 150 was the primary end-point analyzed. Children and adults were analyzed separately since the decision to transplant or not to transplant may differ between the two populations. Log rank statistics and multivariable Cox regression analyses showed that adults at 95% to > 145% of ideal body weight (BW) experienced comparable non-relapse mortality and survival. In contrast, survival among patients at 85-95% or < 85% of ideal BM was significantly worse (P = 0.004 and P = 0.0001, respectively) than in the 95-145% weight category. Results in children were similar except that the differences were less prominent (comparisons of < 85%, 85-95% and > 145% categories vs. 95-145% category showed P values of 0.22, < 0.01 and 0.66, respectively). The observed weight effect was not explainable in terms of the composition of the lower weight categories in regards to nine other known or suspected risk factors. In addition to weight, patient age, diagnosis, type of transplant, year of transplant, graft-versus-host disease (GVHD) prophylaxis and GVHD grades II-IV were also significantly associated with outcome. Thus, the present analysis shows that underweight patients are at an increased risk of death in the early period after transplant.
Design and Implementation of Population Census Data Collection System Based SIMG (2006)

The core idea of Spatial Information Multi-grid(SIMG) is introduced and the structure of spatial information multi-grid for population census(SIMGPC) is designed.The key technologies are expatiated on the method to measure off grid,code and SIMG database.A population census data PDA collection system with spatial information code is designed and implemented.
<i>In vivo</i> genotoxicity and cytotoxicity assessment of a novel quinoxalinone with trichomonacide activity (2012)

The compound VAM2-6 (1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4-dihydroquinoxalin-2(1H)-one) has previously been shown to have an in vitro efficacy of 100% at a concentration of 100 µg ml(-1) against Trichomonas vaginalis, a protozoon parasite that causes the sexually transmitted disease trichomoniasis. Because VAM2-6 is a quinoxaline derivative and given the lack of studies on the genotoxic activity of this compound, the present study was undertaken to evaluate its ability to induce DNA damage in the peripheral blood of mice using single-cell gel electrophoresis (SCGE or comet assay) and the micronucleus (MN) assay. Cell viability was assessed using a fluorochrome-mediated viability test. The compound was tested on CD1 mice at 60, 40 and 10 mg kg(-1) body weight administrated intraperitoneal (i.p.) in a single dose. Peripheral blood samples were collected 24 and 48 h after treatment. N-Ethyl-N-nitrosourea (ENU) was used as a positive control for the comet and micronucleus assays. The results showed that i.p. VAM2-6 induced single-strand DNA breaks and increased the average number of micronuclei in the treated mice in a dose-dependent manner at 60, 40 and 10 mg kg(-1). Cell viability decreased at 24 h but recovered at 48 h for all three evaluated doses. Therefore, the chemical structure of VAM2-6 should be modified to reduce its genotoxic potential.
Dual stack filters and the modified difference of estimates approach to edge detection (1997)

The theory of optimal stack filtering has been used in the difference of estimates (DoE) approach to the detection of intensity edges in noisy images. The DoE approach is modified by imposing a symmetry condition on the data used to train the two stack filters. Under this condition, the stack filters obtained are duals of each other. Only one filter must therefore be trained; the other is simply its dual. This new technique is called the symmetric difference of estimates (SDoE) approach. The dual stack filters obtained under the SDoE approach are shown to be comparable. This allows the difference of these two filters to be represented by a single equivalent edge operator. This latter result suggests that an edge operator can be found by directly training a (possibly nonpositive) Boolean function to be used on each level of the threshold decomposition architecture. This approach, which is called the threshold Boolean filter (TBF) approach, requires less training time but produces operators that are less robust than those produced by the SDoE approach. This is demonstrated and interpreted via comparisons of results for natural images.
Periodontal healing of replanted dog teeth stored in Viaspan, milk and Hank's balanced salt solution (1992)

This study examined, histologically, periodontal healing and root resorption of replanted dogs teeth stored in Viaspan for different time periods and compared these healing patterns to those after storage in milk or Hank's balanced salt solution (HBSS). Seventy-two beagle incisors were endodontically treated, extracted, randomly divided and placed in Viaspan or milk for 6, 12, 24 and 36 h, and Viaspan or HBSS for 36, 48, 72 and 96 h, after which they were replanted. Four negative control teeth were immediately replanted while four positive controls were allowed to dry for one hour before replantation. All replanted teeth were splinted for 14 days. Two months after replantation the dogs were killed and the teeth histologically examined for healing of the supporting tissues. For Viaspan neither replacement nor inflammatory root resorption was seen after 6 and 12 h storage. A statistically significant rise in the incidence of replacement resorption was seen at 24, 36 and 48 h which decreased again at 72 and 96 h to levels equal to storage for 6 and 12 h. The occurrence of inflammatory root resorption was low and significantly increased only at 48 h after which it decreased significantly again. Viaspan proved superior to milk as a storage medium. Teeth stored in HBSS showed healing results similar to those stored in Viaspan.
Sequence-selective 5-methylcytosine oxidation for epigenotyping (2005)

Methylation of DNA is an epigenetic modification that can play an important role in the control of gene expression in mammalian cells. The development of a simple and convenient method for site-specific discrimination of cytosine methylation is imperative for genomic studies. Here we report a facile method for distinguishing between cytosine and 5-methylcytosine. Osmium tetroxide caused the dihydroxylation of the C5-C6 double bond of 5-methylcytosine under an appropriate reaction conditions. The oxidation of 5-methylcytosine-containing target DNA was controlled by hybridization with a guide DNA. This technique facilitates the typing of cytosine methylation at a specific site of the target DNA.
Fault Tolerance for Fight Through (FTFT) (2013)

Abstract : When our cyber defenses' ability to prevent, avoid, and detect an attack are outmaneuvered and our information systems face impending loss of critical services, a fight-through capability must remain; otherwise restoration of those services may come too late for us to emerge undefeated. The task of protecting the protector drives us to create a fight-through capability that is hardened and heavily defended in cyberspace; however, these attributes alone are a Maginot Line that begs the question of why cyber attacks succeed in the first place. The more realistic goal is to design a fight-through capability that can absorb punishment and then rebound so that it can be the basis for restoration of critical services. Adaptations of fault-tolerant computing concepts have been applied to address needs in cyber defense. We likened the fight-through problem to an Observe, Orient, Decide, and Act (OODA) loop. Redundancy, as the underpinning of fault tolerance, was strategically placed to counter an attacker's optimal strategies. The fight-through OODA loop was aimed to outperform the adversary's OODA loop.
Variability of QRS-shape and heart rate in magneto/electrocardiograms of healthy subjects and risk patients (2002)

Bandlimited frequency components are used to estimate the variability of QRS-shape and heart rate. Utilising complex binomial filters, the applied signal processing method allows to analyse envelope and phase (current frequency) of the bandpass signal independently of each other. A beat-to-beat analysis of envelope and current frequency of the entire QRS interval gives an estimate of the QRS variability. A short term heart rate variability is calculated in terms of the heart frequency deviation of the continuously filtered cardiac signal which is determined by the bandwidth of the envelope spectrum in the vicinity of the mean beat frequency. Mean-to-standard deviation ratio of the envelope and current frequency and the heart frequency deviation are combined to a parameter that separate cardiac signals of patients suffering from ventricular arrhythmia from cardiac signals of healthy persons.
ChemInform Abstract: Substrate‐Directable Chemical Reactions (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
"First-Wave" Bias When Conducting Active Safety Monitoring of Newly Marketed Medications with Outcome-Indexed Self-Controlled Designs (2014)

Large health care databases are used extensively for pharmacoepidemiologic studies. Unique methodological issues arise when applying self-controlled designs (i.e., using within-person comparisons) for active surveillance of newly marketed drugs. We use 3 examples to illustrate bias related to population-level exposure time trends when using outcome-indexed self-controlled (i.e., case-crossover) designs for active surveillance and evaluate the ability of the case-time-control design to adjust for bias from population-level exposure time trends. We mimicked active surveillance by conducting sequential analyses after market entry for 3 medications and outcomes (valdecoxib for myocardial infarction (MI), aripiprazole for MI, and telithromycin for acute liver failure) using Medicaid Analytic eXtracts (from all 50 US states, 2000-2006). The case-crossover exposure odds ratio (EOR) in the months immediately following valdecoxib market entry implausibly suggested a 12-fold higher risk of MI during exposed time relative to unexposed time; among age-, sex-, and time-matched controls, the corresponding EOR of 4.5 indicated strong population-level exposure time trends. Over subsequent monitoring periods, case-crossover EORs rapidly dropped to 1.4. Adjustment for bias from population-level exposure time trends with the case-time-control analysis resulted in more consistent associations between valdecoxib and MI across sequential monitoring periods. Similar results were observed in each example. Strong population-level exposure time trends can bias case-crossover studies conducted among "first-wave" users of newly marketed medications. Suggested strategies can help assess and adjust for population-level exposure time trends.
Patterns of thermal adaptation of <i>Bacillus simplex</i> to the microclimatically contrasting slopes of ‘Evolution Canyons’ I and II, Israel (2006)

Summary Identification of selective forces that drive evolution and speciation of bacteria in natural habitats is a central issue in bacterial ecology and evolution. Exploring the adaptive evolution of Bacillus simplex at ‘Evolution Canyons’ I and II, Israel, we report here on the impact of high heat stress on the speciation progress of individual evolutionary lineages. These canyons represent similar ecological replicates, separated by 40 km, in which the orientation of the sun yields a strong sun‐exposed and hot ‘African’ south‐facing slope (SFS) versus a rather cooler and mesic‐lush ‘European’ north‐facing slope (NFS) within a distance of only 50–100 m at the bottom and 400 m at the top. Among 131 strains studied, in Luria–Bertani broth, ‘African’ strains grow better than ‘European’ strains at a stressful high temperature (43.25°C). The results suggest that adaptation to the hotter and more stressful SFS is continuously ongoing. The patterns of heat adaptation override the phylogenetic history of individual lineages. A positive correlation of growth rates at 43.25°C and 20°C, more markedly among ‘African’ strains, reflects probably the broader temperature range on the SFS. Summarizing, the hot temperature stress on the ‘African’ slope is a major environmental force driving the twin evolutionary processes of adaptation and speciation of B. simplex at ‘Evolution Canyon’. Finally, we discuss the data in light of current controversies on species concepts.
A Novel Technique for Reducing Cooling Load of an Air Conditioning System Operating in Hot and Humid Climates (2013)

Cooling load is the energy needed to be removed from a space by a cooling system to provide the desired level of comfort. Large space load requires high energy from the cooling system. A new technique of reducing the cooling load using condensate to pre-cool air stream entering the evaporator of a vapor compression air-conditioning system is presented in this paper. In a cooling process, water vapor condensation normally occurs when the evaporator coil surface temperature becomes lower than the dew point temperature of the humid air entering the evaporator. The cooling process results in appreciable amount of condensate in climatic conditions with high relative humidity and temperature such as those in Dhahran, Saudi Arabia. The rate of condensate yield is calculated using actual climate data of three typical summer days of Dhahran area for the months of June, July and August. These months are the most humid and hottest during the year. Each month is represented by a typical day determined by the average of the three hottest and humid days during the same months of the past three years. It is found that the condensate obtained during night time is more than the day time because of the high relative humidity at night. The results indicate that the cooling load can be reduced up to 10 % when the air entering the evaporator is pre-cooled by 4 °C using the condensate. In addition, the daily condensate yields from the evaporator coil in June, July and August are 1.27, 0.92 and 1.31 kg/kW-CDD, respectively.
Raloxifene Treatment Is Associated With Increased Serum Estradiol and Decreased Bone Remodeling in Healthy Middle-Aged Men With Low Sex Hormone Levels (2004)

The antiresorptive effect of raloxifene was only detectable in men with low baseline estradiol levels. Unlike in postmenopausal women, the increase of estradiol may contribute to the antiresorptive effect of raloxifene in men.
Thyroid Refractoriness in an Athyreotic Cretin Fed Soybean Formula (1965)

GOITER and hypothyroidism have occasionally been reported in infants fed soybean diets.1 2 3 4 5 in these patients both goiter and hypothyroidism have disappeared when soybean was eliminated. Since 1959 a widely used commercial brand of soybean has been supplemented with iodide,6 and to our knowledge no further cases of soybean-induced goiters have been observed.The athyreotic cretin described below showed persistent hypothyroidism while being fed a soy formula, in spite of receiving large doses of desiccated thyroid. Since laboratory animals on soy diet acquire goiter associated with fecal wastage of thyroxine7 8 9 we proposed that refractoriness of this infant to exogenous thyroid might . . .
Redistribution of Trialkyl Silanes Catalyzed by Iridium Silyl Complexes (2012)

[Ir(COE)2Cl]2 reacts with Et3SiH at 23 °C to form a binuclear iridium complex (Et3Si)2(H)2Ir(μ-Cl)2Ir(H)2(SiEt3)2, 1. Complex 1 reacts further with Et3SiH at 60 °C to form a second binuclear iridium complex, Et3Si(H)2Ir(μ-SiEt2)2Ir(H)2SiEt3, 2, containing bridging Et2Si groups. Activation of 2 with H2 produces trace quantities of a very highly reactive but unobservable species which rapidly and efficiently catalyzes alkyl redistribution reactions of silanes, RR′R″SiH. D2 and silane exchange experiments establish reactivity features of both 2 and the reactive intermediate. The intermediate cannot be observed, but it is likely a monomeric iridium silyl silylene complex that catalyzes alkyl scrambling via silane exchanges coupled with 1,3-alkyl migrations between silicon centers. DFT calculations support such a mechanism.
Anthropocène, Exosomatisation et Néguentropie (2020)

M. Montévil, B. Stiegler, G. Longo, A. Soto, C. Sonnenschein, ANTHROPOCÈNE, EXOSOMATISATION ET NÉGUENTROPIE, dans B. Stiegler (curat.) "BIFURQUER, Eléments de réponses à Antonio Guterres et Greta Thunberg", PARIS, 2020: (AnthropoceneNeguEntrop.pdf)
Frequency Modulation Response of a Liquid Crystal Electrooptic Device Doped with Guanine Oligonucleotides (2011)

We have fabricated a twist nematic liquid crystal (TN) cell doped with guanine oligonucleotide (G10b) and measured its voltage-dependent transmittance (V–t) response. It is found that the operating voltage of a TN cell doped with G10b is higher than that of an undoped cell at 10 Hz. At a high frequency above 100 Hz, the V–t curve tends toward a saturated value equivalent to that of an undoped cell. The increase in the operating voltage depends on the concentration of G10b. This result suggests that G10b acts as an ion and produces an opposing electrical field between the electrodes.
Release from G0/G1 arrest induced by dimethyl sulfoxide in human lymphoid cells: regulation of synthesis and activation of the p33cdk2 and p34cdc2 kinases. (1994)

Raji cells, a human Burkitt's lymphoma-derived cell line, will accumulate in a G0-like state upon prolonged (5-6 days) incubation in medium containing 1.5% dimethyl sulfoxide (DMSO). After removal of DMSO, the cells reenter the cell cycle in a synchronous manner and proliferate. After 5.5 days incubation in DMSO, S phase entry occurs at about 21-24 h after release, which is about the length of the first G1 phase of normal human lymphocytes which are stimulated in vitro to enter the cell cycle. The G0-like state of arrested cells and the sequence of events occurring after release from DMSO mimic, in most ways studied, those of normal lymphocytes. Arrested Raji cells lack many cell cycle-regulated molecules, including cyclin A, proliferating cell nuclear antigen, and the p34cdc2 kinase. They contain only hypophosphorylated p110Rb and a low level of enzymatically inactive p33cdk2 kinase. After reentering the cell cycle, a series of events occurred, including phosphorylation of p110Rb and accumulation of the cyclin A and proliferating cell nuclear antigen proteins in mid-G1 and the accumulation of the p33cdk2 and p34cdc2 proteins beginning in late G1, just prior to S-phase entry. Cyclin E levels in Raji cells appeared to be less regulated than in normal cells, with high levels of this protein being present in resting cells and throughout the entire cell cycle. The time courses of activation of the p34cdc2 and p33cdk2 kinases were similar; both became detectable at about 21 h after release and increased greatly in early S.(ABSTRACT TRUNCATED AT 250 WORDS)