gebhart/patrepeval huggingface dataset:
Implementasi Program Pengendalian Resistensi Antibiotik dalam MendukungProgram Patient Safety (Implementation of Antibiotics Resistance Control Program to Support Patient Safety Program) (2013)

ABSTRACT

Patient safety is currently the issue among healthcare institutions and are obliged in all aspects of service. Law requires hospitals to implement patient safety standards. Results of a research collaboration between Indonesia and the Netherlands in Dr. Soetomo Hospital Surabaya and Dr. Kariadi Hospital Semarang in 2000-2004, showed that there were already harmful multi-resistant microorganism. Programmes and activities of PPRA in Dr. Soetomo Hospital generally can be implemented properly. Implementation in the Internal Department in 2009 has increased appropriateness of antibiotic indications from 52,94% to 65%. It optimizes efficacy, prevents the emergence of antibiotic resistance, and reduces losses and ultimately supports patient safety program. Cost analysis showed cost savings of Rp. 203.000 per patient during hospitalization. Implementation of PPRA can improve the quality of infection management and cost effective. Key words: antimicrobial resistance in Indonesia (AMRIN) study, antibiotic resistance control programs, patient safety, cost effectiveness
<i>IN VITRO</i> Ca<sup>2+</sup> DEPENDENT PROTEOLYSIS IN BRAIN TISSUES: A POSSIBLE SOURCE OF ERROR IN TRANSMITTER METABOLISM STUDIES (1974)

Abstract —The effects of Ca 2+ ions on the metabolism of [ 3 H]serotonin and [ 3 H]‐labelled catecholamines have been examined in hippocampal slices or synaptosomes. The formation of [ 3 H]‐5 hydroxyindoles ([ 3 H]serotonin + [ 3 H]‐5 hydroxyindoleacetic acid) from [ 3 H]tryptophan and that of [ 3 H]‐labelled catecholamines from [ 3 H]tyrosine were increased when Ca 2+ was omitted from the incubating medium. However, the total synthesis of 5‐HT from tryptophan and that of catecholamines from tyrosine did not seem to be significantly changed. Altered formation of tritiated amines were due to changes in the specific activities of respective precursor amino acids. This reflected altered sizes of the free amino acid pools caused by Ca 2+ ‐dependent in vitro proteolysis. This must be taken into consideration when studying in vitro Ca 2+ dependency of neutrotransmitter metabolism.
Resistance to echinocandins comes at a cost (2012)

The emergence of Candida strains carrying FKS1 hotspot mutations associated with resistance to echinocandins is cause for concern. However, to assess the potential of such strains to spread within the community and cause lethal infection, the impact of FKS1 mutations on Candida fitness must be determined. We present evidence that C. albicans fks1 mutations carry significant fitness and virulence costs, which are associated with the production of a thickened, chitin-rich cell wall, impaired filamentation and induction of a dampened inflammatory response. If these phenotypic changes remain stable, they can serve as a basis for rational design of strategies to control the spread of echinocandin resistance.
<title>The Reaction Of Fluorine And Chlorine Atoms With Formaldehyde And Deutero-Formaldehyde</title> (1983)

As a result of recent work, gas phase metathetical reactions of formaldehyde represent a particularly well-studied group of chemical reactions'-<sup>8</sup>. A wide variety of studies have been conducted including real-time108-8 and relativerate kinetics<sup>9</sup>, product energy distributions2'10'<sup>11</sup> and theoretical calculations<sup>12</sup>. The interest prompting these studies is two-fold. First, the removal of reactive species, such as atomic chlorine, from the stratosphere via reaction with formaldehyde could have a tremendous impact on the ecological effects of anthropogenically released substances. Secondly, these reactions are generally quite fast and are of considerable interest from a dynamic point of view.
Neural network models for spatial data mining, map production, and cortical direction selectivity (2003)

Hair follicle development serves as an excellent model to study control of organ morphogenesis. Three specific isoforms of TGF-beta exist which exhibit a distinct pattern of expression during hair follicle morphogenesis. To clarify the still elusive role of these factors in hair follicle development, we have used a combined genetic and functional approach: analysis of hair follicle development in mice with disruptions of the TGF-beta1, 2, and 3 genes was coupled with a direct functional test of the effect of added purified factors on fetal hair follicle development in skin organ cultures. TGF-beta2 null mice exhibited a profound delay of hair follicle morphogenesis, with a 50% reduced number of hair follicles. In contrast to hair follicle development, growth and differentiation of interfollicular keratinocytes proceeded unimpaired. Unlike TGF-beta2-/- mice, mice with a disruption of the TGF-beta1 gene showed slightly advanced hair follicle formation, while lack of the TGF-beta3 gene did not have any effects. Treatment of wild-type, embryonic skin explants (E14.5 or E15.5) with TGF-beta2 protein in either soluble form or slow release beads induced hair follicle development and epidermal hyperplasia, while similar TGF-beta1 treatment exerted suppressive effects. Thus, the TGF-beta2 isoform plays a specific role, not shared by the other TGF-beta isoforms, as an inducer of hair follicle morphogenesis and is both required and sufficient to promote this process.
Effect of angiotensin II and sodium depletion on angiotensinogen production (1980)

An in vitro preparation of liver slices was used to study the effect of angiotensin II and sodium depletion on the synthesis of angiotensinogen in rats. Two other treatments known to increase plasma angiotensinogen concentration in vivo, viz., intraperitoneal administration of dexamethasone or ethinyl estradiol, resulted in an increase in the rate of release of angiotensinogen by liver slices; this increase was inhibited by adding actinomycin D or vincristine to the incubation medium. Intravenous infusion of angiotensin II (33 ng/min for 3 days) also produced a marked increase in the release of angiotensinogen concentration and a decrease in plasma renin activity. In contrast, no change in the rate of release of angiotensinogen was observed in rats depleted of sodium for 7--14 days, even though these animals exhibited a marked increase in plasma angiotensin II concentration. Plasma angiotensinogen concentration decreased by 30%, presumably as a consequence of the accompanying increase in renin secretion. These results provide further evidence that the synthesis of angiotensinogen may be increased by angiotensin II, but indicate that the circulating level of angiotensin II in sodium-deficient animals is not sufficiently high to produce this response.
Polymer-Fibrous Glass Composites: Advances and Potential Properties (1971)

The 1960-1970 decade marked the "start of something new" for fibrous glass composites. A remarkable growth in RTP (reinforced thermoplastics) occurred. Chemically tailoring a polymer with the sole intent of combining it with fibrous glass is now a reality. In the thermoset area, SMC (sheet molding compound) and BMC (bulk molding compound), including low profile systems, are getting general industry acceptance. A partial explanation for all the activity with fibrous glass composites is stated in terms of polymer property improvements resulting from the addition of glass. Consideration is also given to the importance of polymer chemistry in obtaining adhesion to glass. Potential strengths are given for a selected system based on a theoretical model.
Surface Plasmon Polaritons: Guided-wave Devices and Applications (2015)

The prospect of controlling the interaction of light with matter at nanoscale has been widely studied in recent years, and entails characterizing optical and optoelectronic devices at resolution higher than the diffraction limit. One technique that allows localization of light to sub-wavelength dimensions is through the use of surface plasmon polaritons (SPPs) wherein the interaction of light with free electrons on a metal surface can lead to a bound surface electromagnetic field that is confined to deep sub-wavelength dimensions. Studies based on SPPs merged with the field of nanotechnology have resulted in novel imaging technologies, nonlinear and quantum-optical devices and the ability to design materials with unusual electromagnetic properties with potential applications ranging from enhancing the efficiency of photovoltaic devices to detection of bio-molecules at ultra-small concentrations. Here we report the design of nanophotonic devices based on SPP waveguide structures that would act as a true counterpart to today’s electronic devices, providing orders of increase in data speeds while maintaining nanoscale dimensions. The devices are based on metal-dielectric-metal (MDM) waveguide structures composed of Ag/SiO2/Ag heterostructure that utilizes interference effect within multiple intersecting plasmonic waveguides. We have explored guided-wave devices such as L and T-bends, 4-way-splitters and 2x2-networked structures, wherein by altering the device geometry one can tune its operating frequency, and by changing the angle of incidence one can switch these devices between ON/OFF states. We plan to fabricate and experimentally characterize these devices for applications in color routing, directional filters and optical switches. We discuss preliminary design rules and constraints based on results obtained from finite-difference-time-domain simulations.
Patogeneza udaru niedokrwiennego mózgu - możliwości neuroprotekcji i stymulowania plastyczności mózgu (2018)

Choroby naczyniowe mzgu s jedn z najczstszych przyczyn zgonu i kalectwa, a liczba zachorowa w wielu krajach wiata stale wzrasta.W ostatnich latach dokona si duy postp wiedzy o podstawowych mechanizmach molekularnych odpowiedzialnych za procesy neurodegeneracyjne.Stao si to moliwe dziki wprowadzeniu zwierzcych modeli dowiadczalnych oraz zastosowaniu nowoczesnych metod
Haptic task constraints for 3D interaction (2003)

We have created a haptically enabled fish tank VR that we call Haptic-GeoZui3D that utilizes a set of haptic widget and data object elements to support rapid and intuitive interaction within a large geographical data space. We leverage the center of workspace navigation metaphor with a Phantom 1.0 haptic device situated in a fish tank VR arrangement to provide a synergistic environment for developing, demonstrating and evaluating these haptic elements. We have developed several principles to guide our effort, chief of which is the notion that haptic forces should be used to provide constraints on user tasks, rather than mimic physical object forces. This paper provides a detailed overview of Haptic-GeoZui3D and it's application in path planning for Autonomous Undersea Vehicles (AUVs), as well as some ideas for future development.
[Hereditary sideroblastic anemia: a rare diagnosis]. (2004)

Hereditary sideroblastic anemia is a very rare disease recessive and X-linked that affect heme biosynthesis by deficit or decreased of delta aminolevulinic acid synthase (ALAS) activity. We report a case of a six-month-old boy, admitted in the hospital for anemic syndrome. The hemogram showed anemia (hemoglobin: 4.5 g/dL), frankly hypochronic microcytic and a regenerated (mean corpuscular hemoglobin concentration: 26 g/dL, mean cell volume: 53 fl, reticulocytes: 10 x 10(9)/L) with red cells morphologic disorders in smears (anisopoikylocytosis) without attack of the other lineages; white blood cells: 11 x 10(9)/L (neutrophils: 64% and lymphocytes: 35%); platelets: 350 x 10(9)/L. Examination of bone marrow showed an important erythroid hyperplasia (about 69%) with dyserythropoiesis. Perls stain revealed intense siderosis with 90% of ringed sideroblasts and a large number of siderocytes. Exploration of ALAS2 and ABC7 genes on the DNA of the infant was not found abnormalities. Treatment with pyridoxine corrects moderately the anemia. By the way, we proposed to remind that iron deficiency, inflammatory syndrome and thalassemia are the common microcytic anemia. However, it's mandatory to explore other causes if diagnosis is not solved.
A New Design for the Superconducting Outsert of the GHMFL 42+ T Hybrid Magnet Project (2010)

A new superconducting coil outsert has been designed to be integrated within the existing infrastructure of the GHMFL hybrid project. Based on the novel development of a Nb-Ti Rutherford Cable On Conduit Conductor (RCOCC) cooled at 1.8 K by a bath of superfluid helium at atmospheric pressure, the superconducting coil aims to produce a continuous magnetic field of 8.5 T in a 1.1 m bore diameter. Combined with resistive insert coils, an overall continuous magnetic field of 42+ T will be produced in a 34 mm warm aperture. The main results of the conceptual study are reported including the conductor and coil specifications, the mechanical stress analysis, the coil protection scheme as well as the required cryogenics infrastructure. First developments and tests regarding the RCOCC are also presented.
High resolution optical mapping of cardiac action potentials in freely beating rabbit hearts (2005)

MA were effectively removed from optical signals. Action potential duration measured from optical signals corresponded with those measured from microelectrodes (r2=0.9677). Our method enables us to map action potentials in freely beating hearts.
Atom transfer radical polymerisation of styrene controlled by phosphine-containing coordination compounds of Mo(III)/Mo(IV) (2002)

A controlled polymerisation of styrene has been achieved under ATRP conditions by using a phosphine-containing Mo III /Mo IV system. Linearity of the M n vs conversion plot and low PDI’s are observed in bulk, in a 30% (v/v) PhCl solution, and in a chain extension experiment when using MoCl 3 (PMe 3 ) 3 /BIB. Controlled polymerisation is also observed for a reverse ATRP experiment starting from MoCl 4 (PMe 3 ) 3 /AIBN. The absence of chain transfer and termination is confirmed by NMR and MALDI–TOF analyses of polymers obtained by employing BEB and BIB as initiators.
Introduction to this special section—Seismic survey design (2004)

It is probably true to say that many consider seismic survey design a niche topic in geophysics. Practitioners of this science inhabit a world halfway between that of the geophysicist and that of the operations specialist. They have to consider the geophysical aspects of design as well as the constraints placed upon them by the environment, the recording equipment and, of course, their budgets. While all geophysicists should understand the principles of survey design, few will actually be directly involved in a design study. However, effects of the design are felt all the way through the process, from acquisition to data processing and interpretation. An understanding of the inevitable trade-offs and compromises made during acquisition will help geophysicists to understand the limitations and nature of their data. In addition, as oil companies strive for efficiency and seek to acquire higher-quality and more cost-effective seismic surveys, greater emphasis is being placed on the design process. Given the significance of the topic, staying abreast of its developments is important. That is one of the objectives of this special section.
Simulation of the impact of moving clouds on large scale PV-plants (2014)

A tool for the impact of moving clouds on the power production large scale PV plants has been developed. Focus is on the comparison of different inverter topologies (string vs. central) under real time weather conditions. The effect of a given clouding situation can be simulated and the resulting available DC output power and maximum power point variation, as well as the resulting AC production during passage can be analyzed for a range of representative clouding situations. The developed model include PV plant surface topology (individual panel orientation), irradiation level, panel temperatures, panel mismatch and inverter efficiency characteristics.
Val<sup>8</sup>‐GLP‐1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats (2013)

Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD) in the elderly. Glucagon-like peptide-1 (GLP-1), a modulator in T2DM therapy, has been shown to have neuroprotective properties. However, the native GLP-1 can be rapidly degraded by the enzyme dipeptidyl peptidase IV (DPP IV); the neuroprotective mechanism of GLP-1 in the central nervous system is still an open question, and whether GLP-1 can prevent amyloid β (Aβ)-induced synaptic dysfunction and calcium disorder is still unclear. The present study, by using patch clamp and calcium imaging techniques, investigated the effects of Val⁸-GLP-1(7-36), a GLP-1 analogue with profound resistance to DPP IV, on the excitatory and inhibitory synaptic transmission and intracellular calcium concentration ([Ca²⁺](i) ) in the absence or presence of Aβ1-40. The results showed that 1) Aβ1-40 significantly reduced the frequency of miniature excitatory postsynaptic currents (mEPSCs) and miniature inhibitory postsynaptic currents (mIPSCs) in CA1 pyramidal neurons of rat brain slices; 2) Val⁸-GLP-1(7-36) did not affect the activity of miniature postsynaptic currents but effectively protected against the Aβ1-40-induced decrease in mEPSC and mIPSC frequency; 3) Aβ1-40 significantly increased [Ca²⁺](i) in primary neuronal cultures; and 4) Val⁸-GLP-1(7-36) alone did not change the intracellular calcium level but prevented Aβ1-40-induced persistent elevation of [Ca²⁺](i). These findings demonstrate for the first time that central application of Val⁸-GLP-1(7-36) could protect against Aβ-induced synaptic dysfunction and intracellular calcium overloading, suggesting that the neuroprotection of GLP-1 may be involved in the remodeling of synaptic activity and intracellular calcium homeostasis in the brain.
The surface of a ferromagnetic electron gas (1975)

The ferromagnetic electron gas has often served as a simple model for itinerant ferromagnetism. Linear‐response functions for a ferromagnetic electron gas were first derived by Izuyama, Kim, and Kubo, (1) assuming that both the direct and exchange interactions are of delta‐feunction form. Recently, Kim, Schwartz, and Praddaude (2) have shown that it is necessary to retain a Coulomb form for the direct interaction in order to assure charge conservation. This modification proves to be essential to the treatment of surfaces since an infinite surface energy results if charge neutrality is violated. In this paper we present an approximate solution for the surface of a ferromagnetic electron gas based on the linear response functions of kim et al. and a ferromagnetic extension of the Hohenberg‐Kohn(3) density‐functional formalism.
La Vie politique dans les Deux Mondes, publiée sous la direction d'Achille Viallate, avec une préface d'Anatole Leroy-Beaulieu. Première année, 1er octobre 1906-30 septembre 1907 ; Deuxième année, 1er octobre 1907-30 septembre 1908. 1908 et 1909 (1909)

Muret Pierre. La Vie politique dans les Deux Mondes, publiée sous la direction d'Achille Viallate, avec une préface d'Anatole Leroy-Beaulieu. Première année, 1er octobre 1906-30 septembre 1907 ; Deuxième année, 1er octobre 1907-30 septembre 1908. 1908 et 1909. In: Revue d'histoire moderne et contemporaine, tome 12 N°3, Mai 1909. pp. 203-205.
Measurement and modelling of the defect chemistry and transport properties of ceramic oxide mixed ionic and electronic conductors (2008)

We demonstrate, that an electrolyte probe can be used to measure the difference in oxygen chemical potential across the surface, when an oxygen flux is forced through an oxygen permeable membrane disc. The oxygen flux as well as the total oxygen chemical potential difference is carefully controlled by an oxygen pump. The developed method is tested on a (La 0.6 Sr 0.4 ) 0.99 Co 0.2 Fe 0.8 O 3- membrane. An LSM|YSZ|LSM oxygen pump was attached to one side of the membrane. A conical Ce 0.9 Gd 0.1 O 1.95 (CG10) electrolyte probe was pressed against the other side of the membrane. The voltage difference between the base and the tip of the CG10 probe was recorded with an applied oxygen flux through the membrane. This voltage was used to extract precise values of the surface exchange rate constant, k O . Using these values of k O , the reduced diffusion coefficient, D 0 V , could be extracted from data of the flux and the oxygen chemical potential difference across the membrane measured with the oxygen pump. Furthermore, upon a gas change, the transient voltage signals of the oxygen pump and the probe could be fitted to give values of D 0 V and k O .
Symptomatic intraarticular ganglia of the cruciate ligaments of the knee (1994)

This case report draws attention to the clinical presentation, differential diagnosis, and recommended diagnostic modality and treatment of symptomatic ganglia of the anterior and posterior cruciate ligaments. One patient presented with a recurrent inability to fully extend the left knee. Another patient presented with pain and soreness over the lateral aspect of the knee, including the lateral joint line. The diagnosis of ganglia of the cruciate ligaments was made after clinical, radiographic, and magnetic resonance examination. Both patients were treated successfully with resection of their ganglia using arthroscopic techniques.
Experimental Investigation of a Parametric End Array (1960)

To obtain experimental verification of the expression for an acoustic end-fire array derived by Westervelt a 13.4-Mc crystal, mounted inside a water-filled tank, was driven simultaneously by 13-Mc and 14-Mc transmitters. A small barium titanate probe, free to rotate in the horizontal plane, was used to detect the 1 Mc difference frequency radiated by the interacting carrier beams. This transducer was connected in turn with a sensitive calibrated receiver. The entire system permits a determination of the directivity pattern and the absolute magnitude of the radiated 1-Mc signal. The results of experiments using this arrangement, as well as of trials with both higher and lower difference frequencies, are in good agreement with the theoretical expression mentioned above.
Lattice model of dynamic heterogeneity and kinetic arrest in glass-forming liquids (2013)

We present a new model of glass-forming liquids in which free volume fluctuations drive dynamic heterogeneity and diffusion of mobility. Our kinetic model is developed from a microscopic perspective where free volume creation requires existing free volume nearby as a source of mobility; free volume diffusion and destruction is spontaneous by virtue of its own mobility. Simulations indicate “molten” and kinetically arrested “glassy” regions in parameter space, and a critical point where dynamic length and intermittency time scales grow as power laws. Systems near the critical point contain colonies of free volume that propagate around bubbles of glassified material.