gebhart/patrepeval huggingface dataset:
System-Level Power Analysis of a Multicore Multipower Domain Processor With ON-Chip Voltage Regulators (2016)

In this paper, we study two different ON-chip power delivery schemes, namely, fully integrated voltage regulator (FIVR) and low-dropout regulator (LDO), and analyze their effect on total system power under process variation, assuming a realistic dynamic voltage-frequency scaling (DVFS) system. The impact of different task scheduling algorithms on the overall system power was also analyzed. We find that in a hypothetical 256-core processor, under a per-core DVFS assumption, the FIVR-based power delivery consumes 20% less power than the LDO-based one for a 50% throughput. However, as the number of cores in the processor reduces, the difference in power consumption between the FIVR-based and LDO-based power delivery schemes becomes smaller. For example, in the case of a 16-core processor with per-core DVFS capability, FIVR-based design was found to consume about the same power as the LDO-based design.
Effect of cooling rate on solidification characteristics of aluminium alloy AA 5182 (2004)

Microstructural reactions during solidification of aluminium alloy AA 5182 were investigated using cooling curve analysis to determine the start temperature of the various transformations and the overall evolution in solid fraction. Three cooling rates were studied: 0.5 K s -1 , 1 K s -1 and 2 K s -1 . The key finding of the study is that the main eutectic reaction and subsequent reactions, including Mg 2 Si formation, occur at much lower temperatures and higher solid fractions than previously published. The primary eutectic was found to precipitate between 575 and 588 °C, which corresponds to a solid fraction between 0.87 and 0.91, and Mg 2 Si was found to precipitate between 551 and 560 °C, which corresponds to a solid fraction between 0.96 and 0.97. Increasing cooling rate was observed to result in a slight increase in solid fraction for primary eutectic precipitation from 0.87 - 0.88 at the low cooling rate to 0.89 - 0.91 at the intermediate cooling rate and 0.91 at the highest cooling rate. The highest cooling rate also resulted in a drop in solidus temperature to 461 °C from 500 - 510 °C (at the low and intermediate cooling rates) that led to an increase in the solidification interval from 123 K to 151 K.
Are there temporarily non-infectious dauer stages in entomopathogenic nematode populations: a test of the phased infectivity hypothesis (1999)

Many studies of entomopathogenic nematodes (Heterorhabditidae and Steinernematidae) have reported that only a small proportion (typically < 40%) of infective stages (dauers), even under apparently ideal conditions, actually infect a host. The 'phased infectivity hypothesis' is most frequently invoked to explain this pattern of low infection with entomopathogenic nematodes. It proposes that at a given point in time not all individuals are infectious i.e. infectiousness is delayed in some individuals. We tested experimentally several predictions based on this hypothesis. Specifically, if phased infectivity occurs, we should be able to expose dauers to increasing numbers of potential hosts until dauers no longer infect and still be able to recover viable dauers. These recovered dauers which did not infect should be infectious at some later point in time. However, our results do not support the phased infectivity hypothesis for 3 species of Steinernema: most dauers could be recovered in one sampling round when provided with sufficient suitable hosts. In contrast, Heterorhabditis bacteriophora frequently did not infect all available hosts, and infectious dauers were recovered in subsequent sampling rounds. This result is more consistent with the phased infectivity hypotheses, but further research is needed before we can be more confident in the hypothesis. For all species tested, the number of available hosts influenced population levels of nematode infectivity. This suggests that the infection status of hosts can influence whether a dauer infects. Our results indicate that phased infectivity is not a common phenomenon in entomopathogenic nematode dauers, despite the widespread acceptance of this hypothesis.
INCORPORATION OF ROBOTIC IMAGE-GUIDED SURGERY (RIGS) WITH THE daVINCI-S® SURGICAL SYSTEM (2008)

You have accessJournal of Urology1 Apr 2008INCORPORATION OF ROBOTIC IMAGE-GUIDED SURGERY (RIGS) WITH THE daVINCI-S® SURGICAL SYSTEM S Duke Herrell, Paul M Milhoua, David M Kwartowitz, and Robert L Galloway S Duke HerrellS Duke Herrell More articles by this author , Paul M MilhouaPaul M Milhoua More articles by this author , David M KwartowitzDavid M Kwartowitz More articles by this author , and Robert L GallowayRobert L Galloway More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60838-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "INCORPORATION OF ROBOTIC IMAGE-GUIDED SURGERY (RIGS) WITH THE daVINCI-S® SURGICAL SYSTEM." The Journal of Urology, 179(4S), p. 288 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 288 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information S Duke Herrell More articles by this author Paul M Milhoua More articles by this author David M Kwartowitz More articles by this author Robert L Galloway More articles by this author Expand All Advertisement PDF downloadLoading ...
Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization (2015)

Polymerization of the Z variant alpha-1-antitrypsin (Z-α1AT) results in the most common and severe form of α1AT deficiency (α1ATD), a debilitating genetic disorder whose clinical manifestations range from asymptomatic to fatal liver and/or lung disease. As the altered conformation of Z-α1AT and its attendant aggregation are responsible for pathogenesis, the polymerization process per se has become a major target for the development of therapeutics. Based on the ability of Z-α1AT to aggregate by recruiting the reactive center loop (RCL) of another Z-α1AT into its s4A cavity, we developed a high-throughput screening assay that uses a modified 6-mer peptide mimicking the RCL to screen for inhibitors of Z-α1AT polymer growth. A subset of compounds from the Library of Pharmacologically Active Compounds (LOPAC) with molecular weights ranging from 300 to 700 Da, was used to evaluate the assay's capabilities. The inhibitor S-(4-nitrobenzyl)-6-thioguanosine was identified as a lead compound and its ability to prevent Z-α1AT polymerization confirmed by secondary assays. To further investigate the binding location of S-(4-nitrobenzyl)-6-thioguanosine, an in silico strategy was pursued and the intermediate α1AT M* state modeled to allow molecular docking simulations and explore various potential binding sites. Docking results predict that S-(4-nitrobenzyl)-6-thioguanosine can bind at the s4A cavity and at the edge of β-sheet A. The former binding site would directly block RCL insertion whereas the latter site would prevent β-sheet A from expanding between s3A/s5A, and thus indirectly impede RCL insertion. Altogether, our investigations have revealed a novel compound that inhibits the formation of Z-α1AT polymers, as well as in vitro and in silico strategies for identifying and characterizing additional blocking molecules of Z-α1AT polymerization.
Noradrenaline and Tardive Dyskinesia (1984)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Rib waveguides composed SU-8 photoresist : optical losses measurement (2003)

International audience
Visual Guidance in Control of Grasping (2015)

Humans and other primates possess a unique capacity to grasp and manipulate objects skillfully, a facility pervasive in everyday life that has undoubtedly contributed to the success of our species. When we reach and grasp an object, various cortical areas in the parietal and frontal lobes work together effortlessly to analyze object shape and position, transform this visual information into useful motor commands, and implement these motor representations to preshape the hand before contact with the object is made. In recent years, a growing number of studies have investigated the neural circuits underlying object grasping in both the visual and motor systems of the macaque monkey. The accumulated knowledge not only helps researchers understand how object grasping is implemented in the primate brain but may also contribute to the development of novel neural interfaces and neuroprosthetics.
Life in a Shrinking World: Thermal Physiology and Activity of Diurnal Alpine Mammals in Relation to Climate Change (2011)

The effects of increased global temperatures are being measured in many biological systems. Given the complexity of these systems, their responses to a changing climate are difficult to predict. Physiologic processes are particularly susceptible to temperature, leading to a species specific optimal range of habitable temperatures. As global temperatures increase, species will be exposed to a changing range of potentially stressful temperatures, especially in species currently living at their thermal limits (e.g., alpine mammals). Warming temperatures may force alpine species to move to higher elevations to maintain thermoneutrality. Ultimately, if temperatures increase as predicted, alpine mammals may be unable to move higher and may face localized extinctions. We hypothesize that many alpine mammals are currently living at the upper range of their thermoneutral zone and, in response to warming temperatures alpine mammals will experience ambient conditions above their upper critical temperature which will limit their activity period. We will focus on small diurnal mammals (Uinta ground squirrels and pikas) as they are prolific and potentially susceptible to high temperatures. The proposed study will not only provide sorely needed information on the basic thermal requirements of alpine small mammals, but that information can be used to generate physiologically relevant models to predict future changes in the altitudinal ranges of these species.
TMOD-28. UNDERSTANDING EGFRvIII GENOMIC BREAKPOINTS THROUGH CRISPR MODELING (2016)

Glioblastoma multiforme (GBM) is the most common and aggressive adult intracranial tumor accounting for 50% of diagnosed brain tumors every year. Genotypically, GBM’s express a variety of oncogenic mutations and amplifications including the epidermal growth factor receptor, EGFR. EGFR is the most frequently altered gene in GBM, being focally amplified in 40% of primary tumors. In a majority of these amplified EGFR cases, EGFRvIII is also present. The EGFRvIII mutant receptor is caused by recombination between loci in intron 1 and 7 leading to genomic deletion of exons 2-7, resulting in loss of part of the extracellular ligand-binding domain and constitutive signaling activity. Analysis of EGFR utilizing publically available data uncovered strong epigenetic regulatory signals in intron 1. Break points mapped from EGFRvIII deletions in patient samples and GBM cell lines within intron 1 reveal interesting patterns of deletion coordinates, with breakpoints often falling directly upstream of predicted enhancer regions as defined by the presence of strong ChIP-Seq peaks for histone marks H3K27Ac and H3K4me1. Together, these intron 1 enhancers have been identified as super-enhancers in U87 glioma cells. Chromatin interaction data suggests that these regions interact at long distance with the EGFR promoter. Putative enhancer regions in intron 1 are lost to varying degrees based upon the extent of deletion caused by the EGFRvIII mutation, the consequences of which are unknown. Recent data has defined a phenomena known as enhancer hijacking in which genomic deletion leads to a reorganization of the chromatin interactions within a genomic region. In medulloblastoma this results in enhanced expression of potent oncogenes that have been reorganized into close proximity with cell type specific enhancers. Loss of exons 2-7 and any additional intron 1 epigenetic regulation may lead to significant local chromatin reorganization, the consequences of which are unknown and undeterminable using current EGFRvIII models.
Selective synthesis of .alpha.-chlorocarboxylic acids (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective synthesis of .alpha.-chlorocarboxylic acidsErkki Paatero, Tapio Salmi, and Krister FagerstoltCite this: Ind. Eng. Chem. Res. 1992, 31, 11, 2425–2437Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ie00011a004https://doi.org/10.1021/ie00011a004research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular statistical calculation of the thermodynamic adsorption characteristics of zeolites using the atom–atom approximation. Part 3.—Adsorption of hydrocarbons (1981)

The molecular statistical calculation of the thermodynamic characteristics of adsorption of n-alkanes C1-C5, neopentane, cyclopropane, cyclopentane, cyclohexane, as well as of ethylene and benzene at low (zero) filling of X zeolites has been made, using the atom–ion and point quadrupole approximations. A small correction has been introduced into the values calculated for the parameters of the corresponding atom–ion potential functions of the intermolecular interaction of the atoms of alkane and non-strained cyclane molecules with the zeolite ions. This correction factor was determined by comparing the calculated values of Henry's constant with its experimental values for a few reference systems (ethane–zeolite NaX or NaY, propane–KX zeolite). The corrected atom–ion potentials were than used to calculate the thermodynamic characteristics of adsorption of alkanes C1-C3 on NaX and (partly) on KX and NaY zeolites, as well as those of adsorption of n-butane and n-pentane (with due regard for their rotational isomers), neopentane, cyclopropane, cyclopentane and cyclohexane on NaX zeolite. In all cases, except for cyclopropane, the calculated values are in agreement with experiment. The discrepancy observed in the case of cyclopropane adsorption is attributed to the specific structure of the strained cycle of this molecule. The thermodynamic characteristics of adsorption of ethylene and benzene have been calculated using the atom–ion approximation and the point quadrupole moment approximation for electrostatic orientation intermolecular interaction. The effective quadropole moment of cyclopropane has been estimated using chromatoscopy.
Renal Impairment of Pure Autonomic Failure (2009)

Supine hypertension is difficult to manage in patients with pure autonomic failure (PAF), because treatment can worsen orthostatic hypotension. Supine hypertension in PAF has been associated with left ventricular hypertrophy, but end organ damage in the kidney has not been assessed. We reviewed hemodynamic and laboratory data of 64 male patients with PAF who were 69+/-11 (mean+/-SD) years old. Systolic blood pressure fell by 67+/-40 mm Hg within 10 minutes of standing, with an inappropriately low 13+/-11-bpm increase in heart rate. Plasma norepinephrine levels were below normal (0.62+/-0.32 nmol/L supine and 1.28+/-1.25 nmol/L standing). A control data set of 75 men (67+/-12 years) was obtained from a deidentified version of the Vanderbilt University Medical Center electronic medical chart database. Compared with controls, PAF patients had lower hemoglobin (8.3+/-0.9 versus 9.3+/-0.8 mmol/L; P<0.001), packed cell volume (0.40+/-0.04 versus 0.45+/-0.04; P<0.001), and red blood cell count (4.4+/-0.5 x 10(12) versus 5.0+/-0.5 x 10(12) cells/L; P<0.001). Serum creatinine and blood urea nitrogen levels were elevated in patients. Forty-eight percent of patients with PAF had supine hypertension (supine systolic blood pressure: > or = 150 mm Hg). Serum creatinine was higher in patients with supine hypertension (133+/-44 versus 106+/-27 micromol/L; P=0.021) and estimated glomerular filtration rate was lower (57+/-22 versus 70+/-20 mL/min per 1.73 m2; P=0.022) compared with patients who did not have supine hypertension. These findings may indicate that renal function is diminished in PAF in association with supine hypertension.
Visual planes-based simultaneous localization and model refinement for augmented reality (2008)

This paper presents a method for camera pose tracking that uses a partial knowledge about the scene. The method is based on monocular vision simultaneous localization and mapping (SLAM). With respect to classical SLAM implementations, this approach uses previously known information about the environment (rough map of the walls) and profits from the various available databases and blueprints to constraint the problem. This method considers that the tracked image patches belong to known planes (with some uncertainty in their localization) and that SLAM map can be represented by associations of cameras and planes. In this paper, we propose an adapted SLAM implementation and detail the considered models. We show that this method gives good results for a real sequence with complex motion for augmented reality (AR) application.
MafA Regulates Expression of Genes Important to Islet β-Cell Function (2007)

Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet beta-cells. Here we show that ectopic expression of MafA is sufficient to induce a small amount of endogenous insulin expression in a variety of non-beta-cell lines. Insulin mRNA and protein expression was induced to a much higher level when MafA was provided with two other key insulin activators, pancreatic and duodenal homeobox (PDX-1) and BETA2. Potentiation by PDX-1 and BETA2 was entirely dependent upon MafA, and MafA binding to the insulin enhancer region was increased by PDX-1 and BETA2. Treatment with activin A and hepatocyte growth factor induced even larger amounts of insulin in AR42J pancreatic acinar cells, compared with other non-beta endodermal cells. The combination of PDX-1, BETA2, and MafA also induced the expression of other important regulators of islet beta-cell activity. These results support a critical role of MafA in islet beta-cell function.
Completion Time in Two-user Channels: An Information-Theoretic Perspective (2017)

Consider a multi-user channel, where each user has a large but non-replenishable bit pool to transmit. Completion time refers to the number of channel uses spent by each user to complete its transmission. In this paper, an information-theoretic formulation of completion time is based on the concept of constrained rates, which are defined over possibly different number of channel uses. Analogous to the capacity region, the completion time region characterizes all possible trade-offs among users' completion times. For a two-user multi-access channel, it is shown that the completion time region is achieved by operating the channel in two independent phases: a multi-access phase when both users are transmitting, and a point-to-point phase when one user has finished and the other is still transmitting. Using a similar two-phase approach, the completion time regions (or inner and outer bounds) are established for a two-user Gaussian broadcast channel and a two-user Gaussian interference channel. It is observed that although consisting of two convex subregions, the completion time region may not be convex in general. Finally, optimization problems of minimizing the weighted sum completion time for a Gaussian multi-access channel and a Gaussian broadcast channel are solved, demonstrating the utility of the completion time approach.
Bibliography of relay literature, 1999 IEEE Committee report (2001)

The latest of a series of classified lists of power system relaying references, begun in 1927, is presented. This bibliographic is in continuation to the bibliographies of relay literature, which were published previously and are contained in the following volumes of the IEEE Transactions.
Preparing Electronic Clinical Data for Quality Improvement and Comparative Effectiveness Research: The SCOAP CERTAIN Automation and Validation Project (2013)

In semi-automating data abstraction and conducting a rigorous validation, CERTAIN investigators will semi-automate data collection to conduct QI and CER, while advancing the Learning Healthcare System.
A recurrent laminin 5 mutation in British patients with lethal (Herlitz) junctional epidermolysis bullosa: evidence for a mutational hotspot rather than propagation of an ancestral allele. (1997)

The three genes (LAMA3, LAB3 and LAMC2) that encode the anchoring filament protein, laminin 5, may all harbour pathogenetic mutations in the autosomal recessive blistering skin disorder, junctional epidermolysis bullosa (JEB). Recently, one particular mutation, R635X in the LAMB3 gene, has been found to account for approximately 40% of all JEB laminin 5 mutations (Kivirikko et al., Hum Mol Genet 1996; 5: 231-7). In this study, we assessed the frequency of this mutation in 12 British patients with lethal (Herlitz) JEB using PCR amplification of genomic DNA and restriction endonuclease digestion. The mutation R635X was fond in seven of 24 (29%) mutant alleles, confirming its relative frequency within the British gene pool. In addition, haplotype analysis using intragenic polymorphisms showed that the mutation arose on at least four different haplotype backgrounds, suggesting it represents a mutational hotspot rather than propagation of a common British ancestral allele. These findings support the hypermutable nature of this CpG dinucleotide and have implications in screening for laminin 5 gene mutations in British and other patients with JEB.
Tricho‐Rhino‐Phalangeal syndrome type II (Langer‐Giedion) with persistent cloaca and prune belly sequence in a girl with 8q interstitial deletion (1992)

A patient with the diagnosis of Langer-Giedion syndrome (tricho-rhino-phalangeal syndrome type II) and interstitial 8q deletion was also noted to have persistent cloaca and prune belly sequence. This is the first report of this association. If it postulated that these latter embryonic defects may be due to the chromosome abnormality, supporting the definition of contiguous gene syndrome.