gebhart/patrepeval huggingface dataset:
Acrylic Latices from Redispersable Powders for Peroral and Transdermal Drug Formulations (1986)

Aqueous dispersions of acrylic resins may be converted to pow ders by spray or freeze drying. Such solids contain loose ag glomerates of discrete latex particles, that disintegrate easily into the original latex particles of less than 2 µ;m in diameter. No film formation occurs, provided that the minimum film forming temperature of the latex is not exceeded during drying.Such powders can be redispersed in water in the presence of 3-6 mol% of alkali or organic bases to obtain a stable latex system. This can be used for enteric film coating in the same way as the original latex dispersions.Redispersed methacrylic acid copolymers can be mixed with neu tral, permeable emulsion polymers to adapt the release profile of drugs more specifically to match their pharmacokinetic prop erties. In this way the pH-dependent solubility of methacryic acid copolymers, which controls the release in the gut by dissolution or increasing permeability can be combined with the pH–independent permeability of neutral acrylic ester polymers, to give time controlled retardation. Similar formulations of acrylic resins can also be used to solve several problems of transdermal delivery systems.The described redispersable polymer powders are stable under normal storage conditions, so their handling and use as redispersed aqueous coating formulations is much more easier and will open an extended field of application.
Real-time Vision-based People Counting System for the Security Door (2002)

This paper describes an implementation method for the people counting system which detects and tracks moving people using a fixed single camera. This system counts the number of moving objects (people) entering the security door. Moreover, the detected objects are tracked by the proposed tracking algorithm before entering the door. The proposed system with Intel Pentium IV operates at an average rate of 10 frames a second on real world scenes where up to 6 persons come into the view of a vertically mounted camera.
Service Mobility a challenge for semantic support (2007)

Information and service data aspects of service mobility are in the focus of this paper. Service platform mechanisms (such as service discovery, composition, brokering and mediation) are crucial for the service and information precision, in particular when user enters service domains with unknown service and information offering. Semantic web service properties, service oriented architectures, and service and information ontology are suggested as tools for upgrading existing service platform mechanisms. However, many of today's platform solutions cannot be restructured, so the improvements have to be applied on top of the legacy service platform designs and current network service roaming solutions. This is taken into account when practically analysing the design, the implementation efforts, and the performance overhead. We focus on ontology-based service discovery and composition tests, in particular on the organization of the service information /data. Several solutions for discovering and composing the services when entering a new service domain are discussed, and the complexity of the design / implementations and performance penalties of such solutions are considered.
The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis (1997)

The pathways and identification of cell injury and cell death are of key importance to the practice of diagnostic and research toxicologic pathology. Following a lethal injury, cellular reactions are initially reversible. Currently, we recognize two patterns, oncosis and apoptosis. Oncosis, derived from the Greek word "swelling," is the common pattern of change in infarcts and in zonal killing following chemical toxicity, e.g., centrilobular hepatic necrosis after CC14 toxicity. In this common reaction, the earliest changes involve cytoplasmic blebbing, dilatation of the endoplasmic reticulum (ER), swelling of the cytosol, normal or condensed mitochondria, and chromatin clumping in the nucleus. In apoptosis, the early changes involve cell shrinkage, cytosolic shrinkage, more marked chromatin clumping, cytoplasmic blebbing, swollen ER on occasion, and mitochondria that are normal or condensed. Following cell death, both types undergo postmortem changes collectively termed "necrosis." In the case of oncosis, this typically involves broad zones of cells while, in the case of apoptosis, the cells and/or the fragments are often phagocytized prior to their death by adjacent macrophages or parenchymal cells. In either case, the changes converge to a pattern that involves mitochondrial swelling, mitochondrial flocculent densities and/or calcification, karyolysis, and disruption of plasmalemmal continuity. The biochemical mechanisms of cell death are currently under intense study, particularly concerning the genes involved in the process. Pro-death genes include p53, the ced-3/ICE proteases, and the Bax family. Anti-death genes include ced-9/Bcl-2 and the adenovirus protein EIB. It is clear that ion deregulation, particularly that of [Ca2+]i plays an important role in cell death following either apoptosis or oncosis. Genetic evidence strongly indicates that activation of proteases is an important step, possibly very near to the point where cell death occurs.
School nurses' contribution to young people's future health. (2006)

This article explores how risks around health are managed in UK schools. It is suggested that school nurses could play a pivotal role in driving the health agenda forward in the school environment.
PRESENT STATUS AND FUTURE PROSPECT OF ISOTOPE SEPARATION(I) (1990)

Great changes of uranium isotope separation methods have been made in the past 10 years.In this part of the paper, uranium enrichment plants in the whole world are summarized.The status and future prospect of different methods in 12 countries which produce enriched uranium are discussed and the strategic plans and projects in some countries are outlined.Finally, a brief summary is given comparing the technical and economic sides of the main uranium enrichment methods.
Living alone with Alzheimer's disease: cross-sectional and longitudinal analysis in the REAL.FR Study. (2005)

These results draw attention to the fact that elderly persons with AD living alone are a subpopulation with specific needs which require the development of targeted interventions. Further investigation of the factors associated with the lower mortality rate in AD patients living alone is necessary, and the results of long-term follow-up in this prospective study should shed light on this question.
Field test of interferometric optical fiber high-voltage and current sensors (1994)

Optical fiber sensors are of considerable interest to the electric power industry. Particularly attractive features as compared to conventional instrument transformers include the inherent galvanic isolation of the sensor head from ground potential, less sensitivity to electromagnetic interference, smaller size, and higher safety.
Excretion of<i>Yersinia</i>spp. associated with consumption of pasteurized milk (1990)

Yersinia enterocolitica biotype 1, serotype O.10K was isolated from 19 patients in the paediatric wards of a district general hospital over a period of 3 months. Fifteen cases were patients on the medical ward. Shortly afterwards, Y. enterocolitica biotype 1, serotype O.6, 30 was isolated from a further 17 patients on this ward in 1 month. The same serotypes of Y. enterocolitica were isolated from the pasteurized milk supplied to the ward. Epidemiological evidence indicated that contaminated pasteurized milk was the source of the yersinia organisms excreted by the patients.
Theoretical and experimental descriptions of grain boundaries in rhombohedral α-Al<sub>2</sub>O<sub>3</sub> (1990)

Abstract Tables are given of all coincidence orientations with multiplicity Σ ≤ 36 for rhombohedral lattices with axial ratios in the range of corundum type structures (2.696 < c/a < 2-765). Measurements of the relative orientation of 133 pairs of neighbouring grains in sintered a-alumina showed that near-coincidence boundaries (14 cases) and one-dimensional coincidence boundaries (17 cases) occurred more frequently than would be the case for randomly distributed orientations and that many of these special boundaries contained periodic arrays of grain boundary dislocations. Their Burgers vectors have been determined for a rhombohedral twin boundary in order to decide which one among three possible coincidence descriptions best represents the boundary structure.
Reactions with pyrrolidine-2,4-diones, Part 4: Synthesis of some 3-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial, anti-HIV-1 and antineoplastic agents. (2001)

The condensation of 1,5-diphenylpyrrolidine-2,4-dione (1) with ethyl orthoformate yielded 3-ethoxymethylene-1,5-diphenylpyrrolidine-2,4-dione (2). Reaction of the latter with hydrazine hydrate, secondary amines 7a-c or urea afforded the corresponding 3-substituted aminomethylene-1,5-diphenylpyrrolidene-2,4-diones 3, 8a-c or 9. On the other hand, condensation of 3 with veratraldehyde (5a) yielded 3-[(3,4-dimethoxybenzylidene)hydrazinomethylene]-1,5-diphenylpyrrolidine- 2,4-dione (6). Whereas, cyclization of 9 with the reactive malonate ester 11 produced 3-[(5-butyl-4-hydroxy-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl) methylene]-1,5-diphenylpyrrolidine-2,4-dione (12). The condensation of some selected aromatic aldehydes 5a-c and addition of morpholine (7c) or piperidine (7d) to some of the resulting 3-arylidene-1,5-diphenylpyrrolidine-2,4-diones 13b, c gave the respective 3-substituted methyl-4-hydroxy-1,5-diphenyl-delta 3-pyrrolin-2-ones 14a-c. Selected members of the new series were screened for their in vitro antimicrobial, anti-HIV-1 and antineoplastic activities. Two compounds 14a, b showed pronounced inhibitory activities against Gram-positive bacteria; whereas, in the in vitro anti-HIV-1 screening, only one compound 13c displayed a moderate activity. However, in the antineoplastic screening protocol, the tested compounds were devoid of activity.
Tracking multi-channel electroglottograph measurement of larynx height in singers (1993)

Changes in vertical larynx position during singing were studied in professional singers using the two-channel electroglottograph recently presented by Rothenberg (1992). The main aim of this pilot study was to test the method in an investigation of the laryngeal behaviors of professional singers. The significance of different factors such as pitch and lung volume to vertical larynx position was analysed. Differences in the effect of pitch changes were found between as well as within different singer classifications. The merits and limitations of the method are discussed.
<i>N</i>‐Acetylation of L‐Aspartate in the Nervous System: Differential Distribution of a Specific Enzyme (1985)

L-Aspartate N-acetyltransferase, a nervous system enzyme that mediates the synthesis of N-acetyl-L-aspartic acid, has been characterized. In the presence of acetyl-CoA, L-aspartate was acetylated 10-fold more efficiently than L-glutamate, and the acetylation of aspartylglutamate was not detectable. Within the nervous system, a 10-fold variation in the enzyme activity was observed, with the brainstem and spinal cord exhibiting the highest activity (10-15 pmol/min/mg tissue) and retina the lowest detectable activity (1-1.5 pmol/min/mg). No enzyme activity was detected in pituitary, heart, liver, or kidney. The enzyme activity was found to be membrane-associated and was solubilized by treatment with Triton X-100.
Comparative analysis of faculties’ websites accessibility based on an automatic evaluation (2019)

In the digital age, websites constitute an important source of gathering information. The website owners are responsible for providing the accessibility of their websites to all target groups of end users. This means that all web users can perceive, understand, navigate, interact and contribute to the Web. To ensure web accessibility, many concepts, guidelines and standards have been proposed, such as Section 508, Design for all, ISO/IEC 40500:2012, and others. This paper focuses on Web content accessibility guidelines (WCAG) and includes a comparative analysis of the accessibility of faculties' websites between 2018 and 2019. Therefore, the objective of this research is to investigate the WCAG 2.0 compliance level of faculties' websites in this time period. Web accessibility was assessed using an automatic evaluation tool, called the Web Accessibility Checker. Based on the results, recommendations for improving web accessibility are presented here.
A Subset of Malignant Phyllodes Tumors Express p63 and p40 (2014)

Breast phyllodes tumors are rare fibroepithelial neoplasms of variable grade, and one key differential of malignant phyllodes on core biopsy is sarcomatoid carcinoma. p63 is reported to be sensitive and specific for sarcomatoid carcinoma, with rare expression in phyllodes in limited series. The p63 deltaNp63 isoform, p40, is postulated to be more specific for squamous differentiation but has not previously been evaluated in breast phyllodes or sarcomatoid carcinoma. Tissue microarrays containing 34 unambiguous phyllodes tumors (10 benign, 10 borderline, 14 malignant), 13 sarcomatoid carcinomas, and 10 fibroadenomas were labeled by immunohistochemistry for p63, p40, CD34, and cytokeratins AE1/AE3, 34betaE12, and CK8/18. No borderline phyllodes tumor, benign phyllodes tumor, or fibroadenoma labeled with p63, p40, or cytokeratin. However, p63 labeled 57% malignant phyllodes tumors and 62% sarcomatoid carcinomas, and p40 labeled 29% malignant phyllodes (focal) and 46% sarcomatoid carcinomas. Among established markers, cytokeratins labeled 21% malignant phyllodes tumors (focal) and 100% sarcomatoid carcinomas. CD34 labeled 57% malignant phyllodes tumors and no sarcomatoid carcinomas. Focal p63, p40, and cytokeratin labeling can be seen in malignant phyllodes tumors but not in lower-grade fibroepithelial lesions, and immunoreactivity with these markers alone is not diagnostic of sarcomatoid carcinoma on core needle biopsy. In the differential diagnosis of malignant phyllodes, p40 is a more specific but less sensitive marker of sarcomatoid carcinoma than p63. These results are consistent with the sarcoma literature in which p63 labeling has been increasingly reported and suggest caution in classifying malignant spindle cell tumors of the breast on core biopsy.
Natural Polymers (2012)

In the search for sustainable materials, natural polymers present an attractive alternative for many applications compared to their synthetic counterparts derived from petrochemicals. The two volume set, Natural Polymers, covers the synthesis, characterisation and applications of key natural polymeric systems including their morphology, structure, dynamics and properties. Volume one focuses on natural polymer composites, including both natural and protein fibres, and volume two on natural polymer nanocomposites. The first volume examines the characterization, life cycle assessment and new sources of natural fibres and their potential as a replacement for synthetic fibres in industrial applications. It then explores the important advancements in the field of wool, silk, spidersilk and mussel byssus fibres. The second volume looks at the properties and characterization of cellulose, chitosan, furanic, starch, wool and silk nanocomposites and the potential industrial applications of natural polymer nanocomposites. With contributions from leading researchers in natural polymers from around the globe, Natural Polymers provides a valuable reference for material scientists, polymer chemists and polymer engineers.
Large scale preparation of graphene quantum dots from graphite oxide in pure water via one-step electrochemical tailoring (2015)

A novel electrochemical synthesis for graphene quantum dots (GQD) on a large scale from graphite oxide (GO) in pure water has been proposed.
The Free Radical Fantasy (2006)

Overly exuberant and exaggerated past expectations and claims of the free radical theory have been quieted by extensive randomized, double-blind, controlled human studies. A half century of data demonstrates its lack of predictability and it has not been validated by the scientific method. Widespread use of antioxidants has failed to quell the current pandemic of cancer, diabetes, and cardiovascular disease or to stop or reverse the aging process. Electronically modified oxygen derivatives contribute to the modulation of cellular redox status, which is of primary importance in disease prevention and homeostasis.
Land Suitability Classification for Rational Land Use Planning in County(Gun) Area(II) Determination of the land Use Suitability to Integrate the Classified Values (1996)

As a rational decision-making process of county-level area development, this study designed 3-step framework : function-giving(areal analysis) on unit planning area by decision matrix of land suitability, check of typical characteristics of each function area and formulation of its future development strategies. Two alternatives were suggested as the areal analysis method, of which one is equal ordering / valuing technique of checking indices for land suitability classfication and the other preferential weighting technique. And then, under the algorithm specially defined in this study, land suitability maps(Fig.2,3) of the case study area (Seungju-county area, Chonnam-province, Korea) were drawn from the areal analysis results. By use of land suitability classification results, unique characteristics of typical function areas were defined (on 7 types of alternative 1 , 8 types of II ) and their future development strategies were formulated in the case study area, According to the categorization criteria in this study, all the villages of the case area were classfied as a suitable type of function areas illustrated in this study.
Lectin-based lateral flow assay: proof-of-concept (2016)

Lateral flow assays (LFAs) enable the simple and rapid detection and quantification of analytes and is popular for point-of-care (PoC), point-of-use and outdoor testing applications. LFAs typically depend on antibody or nucleic acid based recognition. We present the innovative concept of a LFA using lectins in the role of the biorecognition element. Lectins are a special kind of glycan-binding protein and the lectin-based LFA herein described was developed for the determination of the glycosylation of free prostate specific antigen (PSA). PSA is routinely used as a biomarker of prostate cancer (PCa) and the glycosylation status of PSA is a more specific marker of disease progress than only the PSA level. Using the lectin-based LFA we were able to detect α-2,6 sialic acid present in fPSA using Sambucus nigra (SNA) lectin. As a negative control, we employed Maackia amurensis lectin II (MAA II) which specifically binds α-2,3 sialic acid. The novel approach presented here can be applied to a wide range of biomarkers that have a significant impact on clinical diagnosis and prognosis, providing an alternative to standard lectin-based assays. The assay uses commercial components and is easily performed by applying a sample to the sampling pad on the lectin-based LFA strip, with results obtained within 10 minutes.
Review: <i>TAHOE: AN ENVIRONMENTAL HISTORY</i>, by Douglas R. Strong (1985)

Book Review| July 01 1985 Review: TAHOE: AN ENVIRONMENTAL HISTORY, by Douglas R. Strong TAHOE: AN ENVIRONMENTAL HISTORYDouglas R. Strong Abraham Hoffman Abraham Hoffman Search for other works by this author on: This Site PubMed Google Scholar Southern California Quarterly (1985) 67 (2): 214–215. https://doi.org/10.2307/41171154 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Cite Icon Cite Search Site Citation Abraham Hoffman; Review: TAHOE: AN ENVIRONMENTAL HISTORY, by Douglas R. Strong. Southern California Quarterly 1 July 1985; 67 (2): 214–215. doi: https://doi.org/10.2307/41171154 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentSouthern California Quarterly Search This content is only available via PDF. Copyright 1985 The Historical Society of Southern California Article PDF first page preview Close Modal You do not currently have access to this content.
Festphasensintern von Prebkörpern aus Pulvergemischen mit vollständiger Löslichkeit der Komponenten / Solid Phase Sintering of Powder Mixture Compacts with Complete Solubility of the Components (1993)

Article Festphasensintern von Prebkörpern aus Pulvergemischen mit vollständiger Löslichkeit der Komponenten / Solid Phase Sintering of Powder Mixture Compacts with Complete Solubility of the Components was published on December 1, 1993 in the journal International Journal of Materials Research (volume 84, issue 12).
Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury (2019)

mTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model in which both pathways were upregulated through concurrent mutations in their GTPase-activating proteins, <i>Tsc1</i> and <i>Depdc5</i>. Unlike former models that induced limited mTORC1 upregulation, hepatic deletion of both <i>Tsc1</i> and <i>Depdc5</i> (DKO) produced strong, synergistic activation of the mTORC1 pathway and provoked pronounced and widespread hepatocyte damage, leading to externally visible liver failure phenotypes, such as jaundice and systemic growth defects. The transcriptome profile of DKO was different from single knockout mutants but similar to those of diseased human livers with severe hepatitis and mouse livers challenged with oxidative stress-inducing chemicals. In addition, DKO liver cells exhibited prominent molecular pathologies associated with excessive endoplasmic reticulum (ER) stress, oxidative stress, DNA damage and inflammation. Although DKO liver pathologies were ameliorated by mTORC1 inhibition, ER stress suppression unexpectedly aggravated them, suggesting that ER stress signaling is not the major conduit of how hyperactive mTORC1 produces liver damage. Interestingly, superoxide scavengers N-acetylcysteine (NAC) and Tempol, chemicals that reduce oxidative stress, were able to recover liver phenotypes, indicating that mTORC1 hyperactivation induced liver damage mainly through oxidative stress pathways. Our study provides a new model of unregulated mTORC1 activation through concomitant upregulation of growth factor and nutrient signaling axes and shows that mTORC1 hyperactivation alone can provoke oxidative tissue injury.