gebhart/patrepeval huggingface dataset:
Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model (2005)

Different mechanisms were proposed for opioid-induced analgesia and antihyperalgesia, which might result in different pharmacodynamics. To address this issue, the time course of analgesic and antihyperalgesic effects of intravenous (i.v.) and sublingual (s.l.) buprenorphine was assessed in an experimental human pain model. Fifteen volunteers were enrolled in this randomized, double-blind, and placebo controlled cross-over study. The magnitude of pain and the area of secondary hyperalgesia following transcutaneous stimulation were repetitively assessed before and up to 150 min after administration of (1) 0.15 mg buprenorphine i.v. and placebo pill s.l., (2) 0.2 mg buprenorphine s.l. and saline 0.9% i.v. or (3) saline 0.9% i.v. and placebo pill s.l. as a control. The sessions were separated by 2 week wash-out periods. For both applications of buprenorphine the antihyperalgesic effects were more pronounced as compared to the analgesic effects (66+/-9 vs. 26+/-5% and 43+/-10 vs. 10+/-6%, for i.v. and s.l. application, respectively). This contrasts the pattern for the intravenous administration of pure mu-receptor agonists in the same model in which the antihyperalgesic effects are weaker. The apparent bioavailability of buprenorphine s.l. as compared to buprenorphine i.v. was 58% with a 15.8 min later onset of antinociceptive effects. The half-life of buprenorphine-induced analgesic and antihyperalgesic effects were 171 and 288 min, respectively. In contrast to pure mu-receptor agonists, buprenorphine exerts a lasting antihyperalgesic effect in our model. It will be of major clinical interest whether this difference will translate into improved treatment of pain states dominated by central sensitization.
The effect of wirebond geometry and die setting on wire sweep (1995)

An effective and convenient method is presented for describing wirebond geometry. The method employs a minimum number of geometric parameters which are directly related to the IC package design. Computational simulation of wirebond behavior with in-plane flow load is carried out. A 2-D creep flow model is used to predict the velocity distribution and the flow load acting on the wirebond. A finite element method, which allows for plastic deformation and large deflection, is used to predict the deformation of and stress distribution in the, wirebond. Comparative analyses of wirebond behavior with different die settings and loop profiles are carried out. The buckling of wirebonds with in-plane flow load is also studied. Very interesting results have been obtained. The numerical results will be useful for the optimal design of IC packages.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Xanthan biopolymer production at increase concentration by pH control (1971)

Abstract Efficient production of xanthan gum by fermentation with Xanthomonas campestris NRRL B‐1459 can be accomplished at concentrations of xanthan in the fermented broth > 3%. This level of more than twice that previously attained by us results from continuously controlling the fermentation pH with alkali. Only a slight decrease in fermentation rate and yield occurs. When ammonia is used for pH control, cell production more than doubles and fermentation time is shortened. However, xanthan yield is decreased by the diversion of additional sugar to growth.
Chemotherapy-Related Cognitive Impairment (2009)

Chemotherapy-related cognitive impairment (CRCI) was first described in the 1970s, but significant recognition of CRCI did not emerge with consistency until the late 1990s. Estimates of frequency now range from 17%-75%, and evidence suggests that CRCI, or "chemobrain" as it is referred to in the lay literature, is of significant concern to patients. A variety of potentially associated factors have been identified, including age, education level, intelligence, and social support; anxiety, depression, and fatigue; disease site, stage, and comorbidities; treatment regimen, timing, duration, and concomitant therapies; and hormonal levels, cytokine levels, damage to neural progenitor cells, and the presence of the apolipoprotein E 4 allele. Controversy exists as to the most suitable neurocognitive tests to evaluate this sequeal of treatment. Neuroimaging techniques are beginning to reveal affected areas of the brain. A neuropsychologist is essential for the assessment, diagnosis, and recommendation of appropriate management strategies for this patient population. Oncology nurses should be aware of available resources, such as relevant Web sites, support groups, neuropsychologists, and cognitive retraining programs, and provide support for patients concerned about or experiencing CRCI.
Unconventional High-Performance Laser Protection System Based on Dichroic Dye-Doped Cholesteric Liquid Crystals (2017)

High-performance and cost-effective laser protection system is of crucial importance for the rapid advance of lasers in military and civilian fields leading to severe damages of human eyes and sensitive optical devices. However, it is crucially hindered by the angle-dependent protective effect and the complex preparation process. Here we demonstrate that angle-independence, good processibility, wavelength tunability, high optical density and good visibility can be effectuated simultaneously, by embedding dichroic anthraquinone dyes in a cholesteric liquid crystal matrix. More significantly, unconventional two-dimensional parabolic protection behavior is reported for the first time that in stark contrast to the existing protection systems, the overall parabolic protection behavior enables protective effect to increase with incident angles, hence providing omnibearing high-performance protection. The protective effect is controllable by dye concentration, LC cell thickness and CLC reflection efficiency, and the system can be made flexible enabling applications in flexible and even wearable protection devices. This research creates a promising avenue for the high-performance and cost-effective laser protection, and may foster the development of optical applications such as solar concentrators, car explosion-proof membrane, smart windows and polarizers.
Robust segmentation of echocardiographic sequences through spatiotemporal planning and by knowledge-based local and global methods (2002)

A new multi-stage approach is proposed for automatic endocardial border tracking on sequences of digital echocardiographic images. To cope with noise and variability as well as to reduce computation, an approximate contour is assessed for the initial frame in 4:1 decimated images. A composite image (GZD) is obtained by a pixel-wise AND operator between the zero-crossing and gradient direction image, where gradient is above a threshold. A motion image, obtained by integrating the GZD images over the sequence, is used to limit ROI, where the only edge elements belonging to the LV endocardial border are collected and connected by a local radial search. Then edge segments are 1:4 zoomed, interpolated and refined by an optimal global search, based on a likelihood function, maximized by Dynamic Programming. This step is repeated for the following frames using the previous contour as a guide. This approach was tested on a set of 15 DICOM files obtained by a digital (Sequoia, Acuson) echocardiographic system. Automatically derived contours show differences with respect to manually defined contours within the range of observers' variability.
Modulation of the expression of p16<sup>INK4a</sup>and p14<sup>ARF</sup>by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence (2002)

Cellular senescence is a terminal growth phase characteristic of normal human diploid fibroblasts. Altered gene expression during cellular senescence is numerous compared to that of younger proliferative cells in culture. We have previously reported that the levels and activities of hnRNP A1 and A2 RNA binding proteins are decreased in senescent human fibroblasts. Both proteins are multifunctional and may influence the expression of mRNA isoforms during development. In this study, we tested whether overexpression of either protein could modulate the mRNA isoforms of the INK4a locus, specifically p14(ARF) and p16(INK4a). Both INK4a mRNA isoforms have been shown to be growth suppressors and deletions of this locus allow cells to escape cellular senescence. We have found that increasing the ratio of either hnRNP A1 or A2 over that of splicing factor SF2/ASF results in the preferential generation of the p14(ARF) isoform. Overexpression of A1 or A2 RNA binding proteins also appear to increase the steady state mRNA levels of both isoforms, suggesting that in addition to alternative splicing, A1 and A2 may effect p14(ARF) and p16(INK4a) mRNA stability. A constitutive decrease in the ratio of hnRNP A1 or A2 to SF2/ASF in senescent fibroblasts is typically accompanied by an increase in the level of p16(INK4a) isoform. Our studies suggest that hnRNP A1 and A2 may exert an important role during replicative senescence by altering expression of cell cycle regulatory proteins through mRNA metabolism.
An overview of the CCITT X.500 directory system (1989)

Discusses the newly emerged international standard for electronic directories. The author sets the background and rationale for the emergence of the directory standards; briefly describes the idealised structure of directory systems; discusses some opportunities for applying a specific directory system; and highlights some of the aspects which clearly require further refinement before being built into products.
A new lossy compression scheme for encrypted gray-scale images (2014)

Compression of encrypted data has attracted considerable research interests nowadays due to distributed processing and cloud computing. In this work, we propose a novel lossy compression scheme for encrypted gray-scale images. The original image is first divided into non-overlapping blocks. Then, it is encrypted by a modulo-256 addition and block permutation. In compression phase, the spatial correlation and quantization are exploited to reduce the compression ratio. At the decoder side, context-adaptive interpolation with an image-dependent threshold is used to make image reconstruction precise. Experimental results show that the proposed scheme achieves better performance compared to the previous work.
d-Fucose Metabolism in a Pseudomonad (1972)

Abstract A soluble, NAD-dependent dehydrogenase which is specific for d-aldohexoses, including d-fucose, d-glucose, d-galactose, d-mannose, d-altrose, d-allose, 2-deoxy-d-glucose, and 2-deoxy-d-galactose, has been purified 335-fold from a pseudomonad capable of using d-fucose as a sole carbon source. Forty-five other sugars and related compounds tested did not serve as substrates and did not affect the rate of d-glucose oxidation. The pH optimum was 8 to 8.5 in Tris-HCl buffer and 9 to 10 in glycine-NaOH buffer. The enzyme was insensitive to thiols and thiol group reagents and was not activated by divalent metal ions. Representative apparent Km values were 5.8 mm for d-fucose, 0.86 mm for d-glucose and 0.08 mm for NAD+. The β anomer of d-glucose was preferred over the α anomer. d-Fuconate was isolated as the apparent product of d-fucose oxidation, indicating that the unstable d-fucono-δ-lactone rather than d-fucono-γ-lactone was the immediate product. This was confirmed by the demonstration that d-glucono-δ-lactone, but not d-fucono-γ-lactone or d-galactono-γ-lactone, could serve as a substrate in the reverse reaction. Thus, it is concluded that β-d-glucopyranose and β-d-fucopyranose are the actual substrates for the enzyme.
Efficacy of ozone in eradication of Legionella pneumophila from hospital plumbing fixtures (1982)

The effect of ozonation of supply water for one wing of an unoccupied hospital building which had positive cultures for Legionella pneumophila from multiple potable water fixtures was studied in a prospective, controlled fashion. Mean ozone residual concentrations of 0.79 mg/liter eradicated L. pneumophila from the fixtures, but so did nonozonated water in the control wing fixtures. The efficacy of the nonozonated water was most probably due to a mechanical flushing effect and to an unexpected rise in the chlorine content of the supply water. Determination of the in vitro activity of ozone against L. pneumophila did not predict the efficacy of its eradication from water fixtures treated with ozone.
Feedback in Data Transmission (1970)

International Telemetering Conference Proceedings / October 13-15, 1970 / International Hotel, Los Angeles, California
ARICO Y UNA LECTURA CRÍTICA DE LA INTERPRETACIÓN MARXISTA EUROCÉNTRICA (2013)

Aricó realiza una relectura de los textos del "Marx tardío", que le permite problematizar la concepción eurocentrica y deudora de la ideología decimonónica del progreso, que predomina en el "Marx maduro". Perspectiva que orientó las interpretaciones marxistas acerca de la realidad latinoamericana y que paradójicamente resulta funcional al capitalismo perisférico local. La reivindicación que hace Aricó del "Marx tardio", implica la aceptación de vias de desarrollo social alternativas a las del capitalismo europeo avanzado, al tiempo que permite ver las causas de la erronea visión que tiene Marx respecto de Bolivar, a las que liga con la influencia de Hegel y de su antibonapartismo teórico-político.
Calibration of diode-laser second-derivative modulation spectrometry with a reference cell (1984)

Diode-laser second-derivative modulation spectrometry is a simple means of measuring trace concentrations of small molecules in the gas phase. For a setup with a reference cell used both for laser frequency locking and as a concentration standard, the calibration algorithm is developed for the general case of nonvanishing nonlinear terms in the power expansion of Beer’s law in both the sample and reference channel. A practical example is given.
Turbo codes for OFDM with antenna diversity (1999)

OFDM with diversity and coding has been proposed as an effective means for achieving high-rates in wireless environments. Turbo codes have been shown to give near-capacity performance in additive white Gaussian noise (AWGN) channels and is being considered to enhance mobile wireless channel performance. In this paper, we present simulation results of an OFDM system with turbo coding. Comparisons with systems employing convolutional and Reed-Solomon (RS) codes are made. We first study diversity, interleaving and soft decoding for convolutional codes. The same structure is employed for turbo codes of similar complexity and varying word size. Even with a low constraint length, convolutional codes have the potential to outperform RS codes, provided that the interleaver and soft decoder are properly designed. We evaluate Turbo code performance under slow fading conditions and study the effects of changing word size. Increasing word size theoretically provides better interleaving between the two component codes. However, this advantage is less clear when the fading rate is significantly lower than the symbol rate, which is typical of the high data-rate system considered here. Under such conditions, the advantage of using two component convolutional codes in turbo codes is limited. A single convolutional code with higher constraint length may be a better choice.
Bioengineers look beyond patents (2013)

Synthetic-biology company pushes open-source models.
Blogging: Rants, Raves, and Random Thoughts (2007)

Unless you have been asleep or just born in the past three years, you will have found many library articles touting the growth and value of the weblog.1 You may also have attended one of the many technology/library conferences, such as Computers in Libraries, and even an ACL Conference and gone to a presentation on blogs. You will have heard that you must blog, and in conjunction use RSS – whatever that is – if you wish to communicate more effectively with your patrons, your staff, or anyone else.2 Hopping on the blogging bandwagon can “save” your institution, make you a better librarian or teacher. As Irene McDermott notes, “Just as it has been imperative for everyone to have a Web page, now everyone with the slightest interest in being au courant must, absolutely must, have a blog.”3 This paper will examine the hype surrounding blogging, the hope or potential benefits of blogging for your institution, as well as the hysteria or negative aspects of blogging. This will be accompanied by comments about my personal experience over the past 4 years with The In Season Christian Librarian. Writing a formal article about blogging seems odd because the style of a blog is casual and conversational and often stream of consciousness. Marshall Brain (2004) says, “There is no particular order to [blogs]. For example, if I see a good link, I can throw it in my blog. The tools that most bloggers use make it incredibly easy to add entries to a blog any time they feel like it.”4 However, given the short time blogs have been around, several doctoral level theses on blogging have appeared in Dissertation Abstracts.5 This paper does not draw on dissertations but does make reference to several formal presentations at conferences in addition to national surveys and white papers. Even after 4 years, much remains unclear and undecided about blogging.
High performance PPMC compression algorithm (2004)

It has been demonstrated with recent software implementations of context modeling the capability of PPM (Prediction by Partial Matching) type of algorithms by J.G. Cleary and I.H. Witten (1984) to achieve very high compression rates. However, the cost is high in terms of computational complexity and low speed. Hardware implementations of compression algorithms are capable of increasing compression speed by at least an order of magnitude compared with same compression methods implemented in software. In this paper we investigate and study the issues related to the simplification of one PPM type of algorithms, the PPMC by A. Moffat (1990) to achieve high performance.
An Intelligent Traffic Classification Based Optimized Routing in SDN-IoT: A Machine Learning Approach (2020)

Due to speedy increase in IoT devices and its QoS requirements, providing networks solutions to meet this demand has become a major research issue. Providing fast and reliable routing paths based on the QoS requirement of IoT device is very vital. Software defined networking is one of the most current interesting development in the field of research. A new paradigm, SDN-IoT, leveraging the advantages of SDN architecture on IoT networks have been proposed to improve network quality. Also, application of artificial intelligence (AI) in SDN for traffic engineering is widely researched. In this work, we first propose a machine learning based traffic load classification into the traffic’s QoS requirements. Then, a deep learning route optimization model based on the traffic classification is proposed. The model chooses the route that meets the QoS demands like latency of the identified traffic. The simulation results show that our proposed solutions perform very well and better than some significant works in the same area.
Genetic Transformation of Wheat (<em>Triticum aestivum</em> L): A Review (2009)

Gradual progress made in genetic transformation of wheat is presented in this paper. Information on promoters, antibiotic, herbicide and auxotrophic markers, and various traits of wheat modified through genetic transformation, is provided. In addition the methods used for wheat transformation are discussed. Though significant efforts have been made for genetic transformation of wheat mainly through particle bombardment method but transformation efficiency is still low for mass production of fertile transgenic plants. Studies on the inheritance of transgenes and its incorporation into commercial elite cultivars are not significant. Agrobacterium mediated transformation seems to have better prospects for wheat transformation in future due to its advantages over particle bombardment. In planta transformation of wheat tissues seems possible only with Agrobacterium .
Real-Time Computing (2024)

Real-time computing is currently undergoing a revival. Many new and exciting applications are being developed, there is a wealth of new research results being produced, and the community of real-time experts is growing at a rapid pace. This revival is largely due to the demand for sophisticated real-time systems, such as space exploration, systems involving robots, and some systems involving expert systems programs [ 1 ]. Some common examples of real-time systems are command and control systems, process control systems, automated manufacturing, flight control systems, avionics, the space station, space-based defense systems such as SDI, visions and robotics, and teams of robots working in hazardous environments. More detailed accounts of these types of demanding applications can be found elsewhere [ 1-6 ].
Acetylation of Monocarboxylic Acids with Ketene (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcetylation of Monocarboxylic Acids with KeteneR. E. Dunbar and Floyd C. GarvenCite this: J. Am. Chem. Soc. 1955, 77, 15, 4161–4162Publication Date (Print):August 1, 1955Publication History Published online1 May 2002Published inissue 1 August 1955https://pubs.acs.org/doi/10.1021/ja01620a060https://doi.org/10.1021/ja01620a060research-articleACS PublicationsRequest reuse permissionsArticle Views236Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nucleic Acid Related Compounds: A Convenient Synthesis of 3-Deazauridine Analogues (1995)

Abstract A novel synthesis of 3-deazapyrimidine glycosides utilizing pyridine-2(1H)-ones or their sodium salts and α-halomonosugars namely D-glucose or D-galactose as starting components is described.