gebhart/patrepeval huggingface dataset:
A New Technique for Direct Analysis of Reperfusion Mechanisms after Lung Ischemia (1998)

335 Increased oxygen free radical (OFR) production with disruption of vascular and parenchymal homeostasis is assumed to cause reperfusion injury after lung transplantation. Up to now this correlation has not been proven in an in vivo animal model. In this study we used an in vivo pig model of warm pulmonary ischemia to determine blood levels of OFR, NO and resulting peroxidation of serum lipids by chemiluninescent measurements (CM) during a six hour reperfusion period. After anesthesia ventilated animals (FiO2 0.5) underwent left lateral thoracotomy and dissection of the left pulmonary hilum. In 6 animals(Group I) left lung warm ischemia was maintained for 90 min after clamping of the hilum and flush with warm ringers lactate via the pulmonary artery. Six further animals underwent the same surgical procedure but without pulmonary ischemia and served as control (Group II). Hemodynamics and gas exchange(part O2) were hourly assessed during the whole study period. Whole blood samples were taken from the pulmonary artery and left atrium before and during lung ischemia as well as hourly during reperfusion. In those samples levels of OFR. NO and hydroperoxy groups of HDL/LDL were determined by chemiluminescent measurement of relative light units (RLU). Statistical analysis of data was done by the non-parametric Wilcox/Rank test. In Group I (lung ischemia) part O2 decreased from 231± 18 at baseline to 150 ± 28 mmHg after 6 hours of reperfusion(p ≤ 0.05). In all animals significant pulmonary edema was observed during reperfusion. In this group a first peak of OFR production was observed 60-90 minutes after completion of surgery (54411 ± 7825 RLU, p=n.s. vs baseline). After returning to baseline level a second more pronounced increase of OFR followed 120 to 180 min after initiation of pulmonary reperfusion(71557 ± 12672 RLU; p<0.05 vs baseline). Both OFR peaks were followed 30-60 minutes later by significant increases of lipid peroxidation of HDL/LDL (2390 ± 431 and 2212 ± 208 RLU respectively; both p≤0.05 vs baseline). NO production showed a significant increase immediately after reperfusion (35938 ± 6523), thereafter declined below baseline to peak again at 180 min (32420 ± 7263) after reperfusion(both p<0.05 vs baseline). In the control group (no ischemia) no changes of part O2 lipid peroxidation and NO levels occured. OFR production, however, increased after completion of the surgical procedure, similar to the first peak seen in Group I, but no further raise was found during the remaining observation period. Reperfusion after lung ischemia results in significant OFR production followed by a similar pattern of peroxidation of serum lipids; in addition, the surgical trauma alone seems to be responsible for further OFR release. This new model allows the direct evaluation of reperfusion injury after lung ischemia using in vivo measurements of OFR activity, subsequent lipid peroxidation and NO production.
Hematopoietic stem cell transplantation in childhood: report from the bone marrow transplantation group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). (2000)

These data reflect the development and present status of HSCT in Italy and provide a basis for patient counseling and health care planning.
Deactivation and promotion of Co catalysts during Fischer-Tropsch Synthesis : A computational and experimental study (2009)

Conference Proceedings - 2009 AIChE Annual Meeting, 09AIChE
Diffraction and coherence in breast ultrasound tomography: a study with a toroidal array (2024)

Ultrasound is commonly used as an adjunct to mammography for diagnostic evaluation of suspicions arising from breast cancer screening. As an alternative to conventional sonography that uses hand-held transducers, toroidal array probes that encircle the breast immersed in a water bath have been investigated for ultrasound tomography. In this paper, two sets of experiments performed with a prototype ultrasound scanner on a phantom and a human breast in vivo are used to investigate the effects of diffraction and coherence in ultrasound tomography. Reconstructions obtained with transmission diffraction tomography (TDT) are compared with conventional reflection imaging and computerized ultrasound tomography showing a substantial improvement. The in vivo tests demonstrate that TDT can image the complex boundary of a cancer mass and suggest that it can reveal the anatomy of milk ducts and Cooper's ligaments.
Imaging state of charge and its correlation to interaction variation in an LiMn0.75Fe0.25PO4 nanorods–graphene hybrid (2013)

Visualization of the state of charge (SOC) in an LiMn(0.75)Fe(0.25)PO(4) nanorods-graphene hybrid nanostructure (LMFP-C) is realized by chemical mapping of the Fe valance state using scanning transmission X-ray microscopy (STXM). The LMFP-graphene interaction strength variation studied by C K-edge STXM has been correlated to SOC variation, i.e. a stronger interaction was observed for sample regions with a higher SOC in LMFP. Such structure-performance correlation opens new perspectives for a rational design of a better performance olivine cathode for lithium ion batteries.
Orientational and translational ordering of sub-monolayer films of passivated multiply-twinned gold clusters (1999)

The influence of the substrate on the translational and orientational ordering in sub-monolayer films of passivated multiply-twinned gold clusters has been investigated using high resolution and dark field transmission electron microscopy. Although clear differences were observed in the degree of translational ordering on amorphous carbon and etched silicon substrates, there was no corresponding variation in the crystallographic orientation of the nanocrystal cores. The results demonstrate that the orientation of passivated clusters with multiply-twinned cores is effectively random with respect to both the superlattice and the substrate.
Mechanism of the Color Reaction between m-Dinitrobenzene and Alkali Cyanide. II. Color Reaction Products of 2, 4-Dinitroaniline with Potassium Cyanide (Organic Analysis. LXXII) (1970)

Four main coloring matters (I, II, III and IV) were isolated in crystalline forms in the color reaction of 2, 4-dinitroaniline with potassium cyanide and their chemical structures were investigated. I was determined as 2, 3-diamino-6-nitrobenzamide. II and III were characterized as 2, 3-dihydro-3-oxo-1H-indazole derivatives as shown in Chart 1. IV was 2, 6-dinitro-3-aminophenol. The schema of reaction to form those coloring matters was also presented.
Self-organizing network architecture for scalable, adaptive, and robust networking (2008)

A new generation network is requested to accommodate a enormous amount of nodes with high diversity and a wide variety of traffic and applications. To achieve higher scalability, adaptability, and robustness than ever before, we propose new network architecture in this paper. The architecture consists of the physical network layer, service overlay network layer, and common network layer mediating them. Nodes and organized networks behave in a self-organizing manner where they operate on local information and interact with each other to provide network services to users and applications. We also allow inter-layer interaction through the common network layer for a network system to be self-organized as a whole and effectively and efficiently react to unexpected failure.
Energy from wood: a survey of industrial use of wood waste (1984)

Wood waste provides a feasible alternative to the more traditional and convenient fuels such as oil and gas. The feasibility of using wood wastes as boiler fuel is discussed.
A direct element resequencing procedure (1978)

Element by element frontal solution algorithms are utilized in many of the existing finite element codes. The overall computational efficiency of this type of procedure is directly related to the element data input sequence. Thus, it is important to have a pre-processor which will resequence these data so as to reduce the element wavefronts to be encountered in the solution algorithm. A direct element resequencing algorithm is detailed for reducing element wavefronts. It also generates computational by products that can be utilized in pre-front calculations and in various post-processors. Sample problems are presented and compared with other algorithms.
Optical properties of cells with melanin (2014)

The optical properties of pigmented lesions have been studied using diffuse reflectance spectroscopy in a noninvasive configuration on optically thick samples such as skin in vivo. However, it is difficult to un-mix the effects of absorption and scattering with diffuse reflectance spectroscopy techniques due to the complex anatomical distributions of absorbing and scattering biomolecules. We present a device and technique that enables absorption and scattering measurements of tissue volumes much smaller than the optical mean-free path. Because these measurements are taken on fresh-frozen sections, they are direct measurements of the optical properties of tissue, albeit in a different hydration state than in vivo tissue. Our results on lesions from 20 patients including melanomas and nevi show the absorption spectrum of melanin in melanocytes and basal keratinocytes. Our samples consisted of fresh frozen sections that were unstained. Fitting the spectrum as an exponential decay between 500 and 1100 nm [mua = A*exp(-B*(lambda-C)) + D], we report on the fit parameters of and their variation due to biological heterogeneity as A = 4.20e<sup>4</sup> +/- 1.57e<sup>5</sup> [1/cm], B = 4.57e<sup>-3</sup> +/- 1.62e<sup>-3</sup> [1/nm], C = 210 +/- 510 [nm] , D = 613 +/- 534 [1/cm]. The variability in these results is likely due to highly heterogeneous distributions of eumelanin and pheomelanin.
A NEW SYNTHESIS OF ARYLPHOSPHONOUS DICHLORIDES<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA NEW SYNTHESIS OF ARYLPHOSPHONOUS DICHLORIDES1Louis D. Quin and J. Stevenson Humphrey Jr.Cite this: J. Am. Chem. Soc. 1960, 82, 14, 3795–3796Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July 1960https://pubs.acs.org/doi/10.1021/ja01499a088https://doi.org/10.1021/ja01499a088research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multianalytical Study of Historical Luminescent Lithopone for the Detection of Impurities and Trace Metal Ions (2015)

We have explored the performance of an integrated multianalytical approach to the analysis of a series of microsamples of historical lithopone (a coprecipitate of ZnS + BaSO4) produced at the beginning of the 20th century, based on the combination of spectrally- and lifetime-resolved photoluminescence (PL) microscopy imaging and electron paramagnetic resonance (EPR) spectroscopy. Multispectral imaging of the PL emission from microsamples revealed the presence of different luminescence centers emitting in the visible spectrum, which we have hypothesized as trace Cu and Mn impurities unintentionally introduced into the ZnS crystal lattice during synthesis, which act as deep traps for electrons. Time-resolved PL imaging analyses highlighted the microsecond decay-kinetic behavior of the emission, confirming the trap state nature of the luminescence centers. EPR confirmed the presence of Cu and Mn, further providing information on the microenvironment of defects in the ZnS crystalline lattice related to specific paramagnetic ions. The multianalytical approach provides important insights into the historical synthesis of lithophone and will be useful for the rapid screening and mapping of impurities in complex semiconductor pigments and other artists' materials.
Self‐Consistent Field Modeling of Three‐Dimensional Morphologies of Branched Lipid Surfactant at Air‐Water Interface (2010)

Abstract Three‐dimensional mesoscopic morphologies and the thermodynamics of structural phase transitions of amphiphilic lipids at air‐water interfaces are studied using self‐consistent field theory. Changing the relative amount of lipids in the system led to a series of 3D morphologic phases with varying average interfacial area per molecule, mimicking a compression of the model membranes. Membranes of both saturated and unsaturated lipids undergo a transition from cylindrical micelle to lamella when the lipid content in the system increases from 2% to about 19–20%. With further increase in the lipid content, saturated lipids first develop non‐uniform quasi‐2D distributions in the lamella and then gradually transform into a hybrid morphology containing quasi‐planar lamellae. In contrast, unsaturated lipids develop reverse‐micellar morphologies. magnified image
A Survey of Methods of Recording Reports of Fish and Wildlife Law Violations (1978)

In a survey of 51 state wildlife law enforcement chiefs, 20 of 50 agencies recorded on a standardized form any citizen reports of violations. Ten of these 20 agencies analyzed data recorded on citizen reports for planning purposes. Seven of the 50 respondents indicated that names of enforcement personnel were accompanied by their professional affiliation in local telephone directories. These results suggest that if an observer desires to report a wildlife law violation in the United States, the probabilities of the report's being successfully completed, recorded, and used in enforcement agency planning are low. Providing business telephones with message-taping capability to field officers is suggested for increasing these probabilities. Professional fisheries managers should continue to support adoption of improved techniques related to man-management.
Identification of Mechanisms of Breast Cancer Metastasis Using Tissue Specific Virus Delivery (2006)

Abstract : To investigate breast cancer metastasis, we propose to use a tissue specific viral delivery system that will allow the somatic delivery of secondary lesions in the background of a tumor-inducing primary oncogene. In the first year of support we established protocols for efficient in vitro cultivation and infection of mammary gland-derived normal, hyperplastic and tumorigenic cells. Conditions are mild enough to allow these cells to grow in the mammary fat pad following re-implantation. Tumors that have been allowed to re-grow in a mammary fat pad keep the characteristics of the original tissue, including expression of the TVA receptor. The continued expression of TVA allows for the introduction of genes to study tumor progression and invasion in vivo. Lentiviral vectors were modified to carry a Luciferase/GFP reporter within a Gateway cassette that bears the candidate gene. Genes associated with tumor progression and metastasis have been cloned into RCAS and lentiviral vectors pseudotyped for ENV A.
Observation of a Soliton Reconstruction of Au(111) by High-Resolution Helium-Atom Diffraction (1985)

From an analysis of diffraction data for Au(111), we deduce that the observed 23-fold periodicity in the $〈110〉$ direction can be described by a regular superstructure of one-dimensional extended stacking faults. We propose that this surface is a realization of the Frenkel-Kontorova model of competing interactions and that the periodic changes in stacking from $\mathrm{ABC}$ to $\mathrm{ABA}$ may thus take the form of solitons. The solitons, of half-width 11.8 \AA{}, lead to an average compression of 4% in the $〈110〉$ direction.
Effect of Cationic Surfactant on Transport of Model Drugs in Emulsion Systems (1997)

Excess surfactant present in emulsions can influence the rates of transport of incorporated drugs by micellar solubilization, alteration of the partitioning process and by drug-surfactant complexation. Cetyltrimethylammonium bromide (CTAB), a cationic surfactant was selected to investigate these phenomena as it forms relatively stable mineral oil-water (O-W) emulsions and has the potential for ionic interaction. Phenylazoaniline, benzocaine, benzoic acid and phenol were chosen as model drugs for this study. The emulsion critical micelle concentration (CMC) for CTAB determined using a combination of a membrane equilibrium technique and surface-tension measurement was 1.0% w/v in 10% v/v% O-W emulsion systems. Ionic interaction between model drugs and surfactants and drug hydrophobicity affected their transport rates in the emulsion systems. The transport rates of the lipophilic drugs (benzocaine and phenylazoaniline) and the ionized hydrophillic drug (benzoic acid, pH 7.0) in the emulsion systems increased with increasing CTAB concentration up to 0.5% w/v micellar concentration and then decreased at higher concentrations. The rate of transport of phenol was not affected by the presence of micellar phase. Ionic interaction between surfactant and model drugs affected transport rates of model drugs in emulsion systems. The micellar phase was considered to affect the overall transport rates of model drugs.
Portal diversion in glycogen storage disease. (1969)

On October 15, 1963, an 8 ½-year-old girl with glycogen storage disease was treated at the University of Colorado by performance of a portacaval transposition.8 The objectives of the operation were to make dietary glucose more readily available to the peripheral tissues by means of the portal diversion, to deglycogenate the swollen liver, and to spare the patient the possible hazards of Eck fistula by restoring a portal inflow with systemic blood from the suprarenal inferior vena cava. The physiologic basis for the undertaking had been laid by extensive investigations in dogs.7,8 The original report of this case speculated that the same result might have been obtained with a simple portacaval shunt, omitting the potentially hazardous anastomosis of the inferior vena cava to the central portal vein.

The enzyme deficiency in the first patient was of hepatic amylo-1,6-glucosidase, thereby classifying the glycogen storage disorder as Type IIIB.3 One and a half years later, a 7-year-old boy underwent the same operation, performed by Riddell, Davies, and Clark6 in Bristol, England, this time for the indication of an hepatic glucose-6-phosphatase deficiency (Type I). Their patient had a stormy postoperative course, with pro-found metabolic acidosis and acute ascites formation, but he ultimately, recovered. The same amelioration of symptoms, as well as rapid body growth, that was seen in the original patient was observed in this one. The child was in good condition when last seen in December, 1967, just before his family's immigration to Canada terminated the possibility of further examinations at the Bristol clinic.5

A third attempt at portal diversion for the treatment of glycogen storage disease has been reported from the Cleveland Clinic by Hermann and Mercer,1 again with encouraging results. However, there was an important deviation from the technique used in the earlier cases inasmuch as no attempt was made to restore portal venous inflow. The patient has not suffered any apparent adverse long-term effects from the Eck fistula.

The foregoing experience has suggested that cautious further exploration of portal diversion for the treatment of glycogen storage disease can be justified. This possibility will be supported in the present report by a 5 year follow-up of the first patient so treated. In addition, a more recent attempt at portacaval transposition which led to death will be described. In the last case, inability of the glycogen-laden liver to transmit an augmented portal venous inflow from the inferior vena cava was the cause of failure. As a consequence, it may be wise in future trials to consider performing only a portacaval shunt, as was done by Hermann and Mercer.1
Hypothalamic Modulation of Adrenal Sympathetic Nerve Activity and the Glucose Counter‐Regulatory Response: Involvement of Medullary and Spinal Glutamate Receptors (2015)

The rostral ventrolateral medulla (RVLM) and perifornical hypothalamus (PeF) control adrenaline release during the glucose counter-regulatory response (GCRR) but the circuitry is not well-defined. In anesthetised rats, we measured ASNA after RVLM or PeF electrical stimulation (0.5Hz, 50-400µA, 1ms). We gave intrathecal kynurenate (KYN; 5µmol/10μl) or vehicle before stimulation and 2-deoxyglucose (2-DG) iv or into PeF after KYN or vehicle into RVLM. Hexamethonium (hex; 20-40mg/kg iv) discriminated pre- and post-ganglionic ASNA responses. In other rats, we injected the tracer CTB into the adrenal medulla and immunoperoxidase stained cord sections for CTB+orexin. After RVLM stimulation, ASNA showed pre- or post-ganglionic early peaks (63±3 ms; 56±6 ms) and pre- or post-ganglionic late peaks (132±7 ms; 139±4 ms). Intrathecal KYN reduced all peaks (P<0.05). After PeF stimulation, ASNA consisted of pre- or post-ganglionic early peaks (84±1 ms; 91±1 ms) and pre- or post-ganglionic late peaks (133±2 ms; 143±2 ms). Hex reduced or abolished all RVLM-evoked peaks but only the PeF-evoked early peak (P<0.05). KYN in RVLM (5nmol/100nl) reduced (P<0.05) ASNA after iv and PeF 2-DG. Orexin terminals apposed sympathoadrenal neurons in the spinal cord. These data implicate a monosynaptic PeF-spinal pathway, long latency pre-ganglionic responses and orexin input in control of adrenaline release. Glutamatergic circuits including PeF, RVLM and spinal cord may underpin the GCRR.
Micromachined dermabraders for plastic surgical applications (2003)

Miniature abrasion tools for potential skin resurfacing applications are created using MEMS fabrication technology. The abrading microstructures are formed on silicon wafers by a one-mask bulk micromachining process based on isotropic xenon difluoride etching. The micromachined abraders (microdermabraders) are packaged and applied to human cadaveric skin to remove wrinkles. Dermabraded and intact skin regions are analyzed qualitatively and quantitatively by light microscopy and image processing techniques. Overall, the microdermabraders performed favorably compared to commercially available plastic microreplicated structures. The microdermabraders provided a consistently uniform cut through the epidermal layers of cadaveric skin, leaving little debris and minimal pitting.
Optical Emission Spectroscopy of an Atmospheric Pressure Plasma Jet during Tooth Bleaching Gel Treatment (2015)

Optical emission spectroscopy was performed during atmospheric pressure plasma needle helium jet treatment of various tooth-bleaching gels. When the gel sample was inserted under the plasma plume, the intensity of all the spectral features increased approximately two times near the plasma needle tip and up to two orders of magnitude near the sample surface. The color change of the hydroxylapatite pastille treated with bleaching gels in conjunction with the atmospheric pressure plasma jet was found to be in correlation with the intensity of OH emission band (309 nm). Using argon as an additive to helium flow (2 L/min), a linear increase (up to four times) of OH intensity and, consequently, whitening (up to 10%) of the pastilles was achieved. An atmospheric pressure plasma jet activates bleaching gel, accelerates OH production, and accelerates tooth bleaching (up to six times faster).