gebhart/patrepeval huggingface dataset:
The NZB mouse as a model for chronic lymphocytic leukemia. (1992)

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and the only leukemia for which a possible genetic component has been described. Analysis of this genetic component has been hindered by the fact that disease onset normally occurs after age 50. We report here the aged NZB mouse as an animal model for CLL. NZB mice have a genetically regulated, age-dependent onset of clonal, aneuploid cells which are IgM+ and Ly1+ (CD5+ B-cells). Peripheral blood smears from old NZB mice show an increase in circulating lymphocytes and "smudged" or ruptured cells, often seen in human CLL. Electron microscopic examination of these cells shows them to be mature lymphocytes. Light microscopy of the spleen shows infiltration of small lymphocytes and is consistent with CLL pathology. These long-lived, CLL-like cells can be serially passaged into recipient animals. This continued passage occasionally results in the development of a large cell lymphoma detectable in the spleen, lymph nodes, and liver. The histology of this lymphoma is quite distinct from that of the CLL-like cells, but the phenotype is that of an aneuploid CD5+, IgM+ cells. This apparently represents a continued transformation of the CLL-like clone similar to the development of Richter's syndrome in human CLL. Therefore, the NZB mouse can be a valuable tool for the determination of the genetic basis of CLL ontogeny and the conversion of CLL into Richter's syndrome.
Determination of vertical and horizontal permeabilities for vertical oil and gas wells with partial completion and partial penetration using pressure and pressure derivative plots without type-curve matching (2005)

it has been long recognized that in some reservoirs the flow does not follow the expected radial cylindrical pattern. Spherical flow may take place in systems with wells completed in thick reservoirs where a short completion interval is open to flow yielding a unique and more complex early-time pressure behavior. Some of the main reasons for partial penetration are to avoid coning of water and minimize sand production. A similar early-time pressure behavior may be due to the presence of plugged perforations. Such well completions are referred to as limited-entry, restricted-entry or partially penetrating wells. A typical case of spherical propagation of pressure transients occurs during the repeat formation tester measurements. Such a test measures spot formation pressures and recovers formation fluid samples for gaining an insight into the reservoir flow mechanics. The purpose of this study is to identify on the pressure and pressure derivative curves the unique characteristics for different flow regimes resulting from these type of completions and to determine various reservoir parameters, such as vertical, horizontal permeability, and various skin factors. The interpretation is performed using Tiab’s Direct Synthesis (TDS) Technique, introduced by Tiab (1993), which uses analytical equations obtained from characteristic lines and points found on the log-log plot of pressure and pressure derivative to determine permeability, skin and wellbore storage without using type-curve matching. The extension of this methodology for the case under study includes wellbore storage and skin effects. It is applied to both drawdown and buildup tests. We found that a spherical or hemispherical flow regime occurs prior to the radial flow regime whenever the penetration ratio of about 20%. A half-slope line on the pressure derivative is the unique characteristic identifying the presence of the spherical/hemispherical flow. The typical half-slope line of theses flow regimes is used to estimate spherical permeability and spherical skin values. These parameters are then used to estimate vertical permeability, anisotropy index and skin. Results of TDS technique where successufully compared to those of conventional technique for field and simulated examples.
High Voltage, Low On-Resistance 4H-SiC BJTs with Improved Junction Termination Extension (2011)

In this work, implantation-free 4H-SiC bipolar transistors with two-zone etched-JTE and improved surface passivation are fabricated. This design provides a stable open-base breakdown voltage of 2.8 kV which is about 75% of the parallel plane breakdown voltage. The small area devices shows a maximum dc current gain of 55 at Ic=0.33 A (JC=825 A/cm2) and VCESAT = 1.05 V at Ic = 0.107 A that corresponds to a low ON-resistance of 4 mΩ•cm2. The large area device shows a maximum dc current gain of 52 at Ic = 9.36 A (JC=312 A/cm2) and VCESAT = 1.14 V at Ic = 5 A that corresponds to an ON-resistance of 6.8 mΩ•cm2. Also these devices demonstrate a negative temperature coefficient of the current gain (β=26 at 200°C) and positive temperature coefficient of the ON-resistance (RON = 10.2 mΩ•cm2).
Truncated cystatin C in cerebrospiral fluid: Technical artefact or biological process? (vol. 5, Issue 12, pp. 3060‐3065) (2005)

Abstract See original http://dx.doi.org/10.1002/pmic.200402039
Preparation and characterization of Cu2SnS3 thin films by electrodeposition (2018)

Cu2SnS3 thin films were electrodeposited on F:SnO2/Glass substrates at room temperature by using aqueous solution. Copper and tin were first electrodeposited from single bath and post annealed in the presence of sulphur atmosphere to obtain the Cu2SnS3 phase. The Cu2SnS3 phase with preferred orientation along the (112) crystal direction grows to greater extent by the post annealing of the film. Raman analysis confirms the monoclinic crystal structure of Cu2SnS3 with principle mode of vibration as A1 (symmetric breathing mode) corresponding to the band at 291 cm−1. It also reveals the benign coexistence of orthorhombic Cu3SnS4 and Cu2SnS7 phases. Optical properties of the film show direct band gap of 1.25 eV with a high absorption coefficient of the order of 104 cm−1 in the visible region. Photo activity of the electrodeposited film was established in two electrode photoelectro-chemical cell, where an open circuit voltage of 91.6 mV and a short circuit current density of 10.6 µA/cm2 were recorded. Fabrication of Cu2SnS3 thin film heterojunction solar cell is underway.
An Investigation of the Commercial Applications of Acrylamide Based Water Soluble Polymers (1985)

In part I of this dissertation, several cationic polyacrylamides were tested under different conditions for their ability to improve the retention of fines in papermaking. A dynamic drainage jar was used to simulate the turbulence encountered in the papermaking process. Several factors, including temperature, the amount and intensity of turbulence, the additive concentration and the presence of impurities were found to affect fines retention with polymers present. A polymer made by Nalco Chemicals proved to be superior to a commonly used polymer, Percol 292 for a standard fine paper pulp. It was thought that further retention improvements might be possible by tailoring the charge density and molecular weight of polyacylamide retention aides for the specific papermaking system they are intended for. Novel approaches to retention such as those employing combinations of an anionic polymer, a cationic polymer and zirconium oxychloride were thought to show promise as well. In part II of this dissertation several broad polyacrylamide molecular weight standards were prepared by inverse suspension and solution processes on pilot plant equipment at the McMaster Institute for Polymer Production Technology. They were characterized by laser light scattering and viscometry at McMaster, and externally by other methods. Although the polyacrylamides prepared compare favourably to currently available commercial standards when both are analysed by SEC, further analysis must be done to be certain of the molecular weight averages. A relationship is presented to provide for simpler and more accurate light scattering analysis in the future. This relationship relating Mw to the second Virial coefficient may be used to eliminate some uncertainty in the often scattered plots encountered when calculating molecular weights for polyacrylamides analysed by light scattering.
Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo (2012)

Apoptosis inhibitor 5 (API-5) is a 55 kDa nuclear protein with potent anti-apoptotic signaling in tumor cells in vitro. In this study, we analyzed the expression of the API-5 protein in vivo in a broad spectrum of human carcinomas, including those of the colon, lung, liver, kidney, pancreas, stomach and esophagus using tumor tissues obtained during tumor resection. The results showed significant upregulation of API-5 expression in biopsies of lung (23%, n=13) and colorectal tumors (33%, n=27) in comparison with biopsies from the adjacent normal tissue. Colon cancer biopsies were used to study the cell populations with an upregulated level of expression of API-5 more closely. Using a magnetic bead-based selection for the epithelial cell marker EpCAM, we purified epithelial cells from the tumor and control tissues and analyzed these cells for API-5 expression by western immunoblotting. We observed that EpCAM-positive tumor cells expressed API-5 in all three colorectal cancer cases tested, in contrast to the control EpCAM-positive and EpCAM-negative cells isolated from the control or tumor tissues. These data suggest that the expression of the API-5 protein is upregulated in tumor epithelial cells and may serve as a prognostic marker in colorectal cancer.
Cholesterol and Triglycerides Moderate the Effect of Apolipoprotein E on Memory Functioning in Older Adults (2007)

We used data from the Betula Study to examine associations between total cholesterol, triglycerides, and apolipoprotein E on 10-year changes in cognitive performance. Tests assessing episodic memory (recall and recognition), semantic memory (knowledge and fluency), and visuospatial ability (block design) were administered to 524 nondemented adults (initial age of 55-80 years); multilevel modeling was applied to the data. Higher triglyceride levels were associated with a decline in verbal knowledge. Lipid levels moderated the influence of apolipoprotein E on episodic memory, such that among epsilon4 allele carriers, decline in recognition was noted for individuals with higher cholesterol levels. Cholesterol and triglyceride levels are pharmacologically modifiable risk factors that account for variation in normal cognitive aging.
Excited State Electronic Landscape of mPlum Revealed by Two-Dimensional Double Quantum Coherence Spectroscopy (2015)

Red fluorescent proteins (RFPs) are widely used probes for monitoring subcellular processes with extremely high spatial and temporal precision. In this work, we employed spectrally resolved transient absorption (SRTA) and two-dimensional double quantum coherence (2D2Q) spectroscopy to investigate the excited state electronic structure of mPlum, a well-known RFP. The SRTA spectra reveal the presence of excited state absorption features at both the low- and high-energy sides of the dominant ground state bleach contribution. The 2D2Q spectra measured at several excitation wavelengths reveal a peak pattern consistent with the presence of more than three electronic states (i.e., ground, excited, and doubly excited). Numerical modeling of this response suggests that the features are consistent with a 1-1-2 electronic structure. The two closely spaced (∼1500 cm(-1)) levels in the double quantum manifold appear at opposite anharmonicities relative to twice the energy of the lowest energy transition. These observations explain the excited state absorption contributions observed in spectrally resolved transient grating and transient absorption measurements and demonstrate the utility of multidimensional spectroscopy in unraveling congested spectra relative to conventional one-dimensional methods.
A double‐blind, placebo‐controlled study of the efficacy and safety of non‐prescription ranitidine 75 mg in the prevention of meal‐induced heartburn (1999)

These data clearly demonstrate that ranitidine 75 mg is effective in completely preventing or decreasing heartburn when administered 30 min prior to a provocative meal.
Modelling and stability of FAST TCP (2005)

We introduce a discrete-time model of FAST TCP that fully captures the effect of self-clocking and compare it with the traditional continuous-time model. While the continuous-time model predicts instability for homogeneous sources sharing a single link when feedback delay is large, experiments suggest otherwise. Using the discrete-time model, we prove that FAST TCP is locally asymptotically stable in general networks when all sources have a common round-trip feedback delay, no matter how large the delay is. We also prove global stability for a single bottleneck link in the absence of feedback delay. The techniques developed here are new and applicable to other protocols.
Identification of Mitotic Blockers by Phenotypic Screening of a Clinical Compound Library (2016)

A phenotypic assay was performed using a clinical compound library to identify the new anticancer agents. HeLa cells were treated with the clinical compounds for 20 h, and then screened for cell morphology to check the mitotic arrest. A total of 2320 clinical compounds were tested, of which two anthelmintic compounds, oxibendazole and oxfendazole, were found to induce mitotic arrest in HeLa cells. Additionally, cell‐cycle analysis revealed strong G2 /M arrest by these anthelmintics. Moreover, the two compounds, especially oxibendazole, exhibited highly cytotoxic effects on several cancer cell lines. In conclusion, we suggest repositioning of the two anthelmintics, oxibendazole and oxfendazole, if normal cells are not affected by these compounds, to cancer treatment.
Polymer-Led encapsulation by means of plasma-assisted ALD AI2O3 films (2008)

Within a 500h test, ALD encapsulated poly-LEDs show approximately half the black spot density of plasma deposited a-SiNx:H (300 nm thick) encapsulated devices. The black spot density is further reduced ifthe a-SiNx:H layer is coupled with an ALD layer and such decrease is accompanied by a massive reduction of the black spot area growth in time. A selection of electroluminescence measurements of encapsulated poly-LEDs point out a very promising application of ALD Al2O3 layers in the field of LED encapsulation and will be interpreted in terms of possible mechanisms related to film growth in multi-layer structures.
Advanced Analysis Identifies Greater Efficiency for Testing BOPs in Deep Water (2004)

Abstract Pressure testing Blowout Preventers (BOPs) with Synthetic-Based Mud (SBM) requires lengthy testing times as a result of pressure/volume/temperature (PVT) influences associated with SBM. PVT influences are especially pronounced in deepwater and high-pressure test environments. This project was motivated by an effort to better understand the mechanics that transpire during BOP testing. The primary objective was to demonstrate that the pressure decline is quantified by the fluid PVT behavior, mechanical influences, and thermodynamics of pressurization and subsequent cool down. The second objective was to demonstrate that the pressure decline caused by a leak can be detected reliably and efficiently with high resolution pressure data. It was theorized that the phenomena primarily result from heat added to the system during pressurization. To pursue this investigation, real-time PVT data was gathered at the cementing unit (CU) suction and discharge while testing the BOP. In addition, pressure-temperature (P-T) gauges were placed in the drillstring: one at the drill floor, one at the midpoint between the drill floor and the BOP, and one above the BOP stack. The gauges confirmed significant heat up as the system was pressured up for each test. The pressure decreased as the system cooled back towards the ambient. Modeling techniques were developed to understand the system response. This paper presents salient aspects of data acquisition, data interpretation, and modeling techniques. Results demonstrate the potential to significantly impact the industry with respect to safety, time, and costs for BOP testing.
Empirical evaluation of deterministic and adaptive routing with constant-area routers (1997)

This paper addresses the issue of how router complexity affects the overall performance in deterministic and adaptive routing under virtual cut-through switching in k-ary n-cube networks. First, the performance of various adaptive routers with constant area are compared. Second, the performance of adaptive and deterministic routers are compared under the same conditions. Finally, it is shown that, under certain conditions, deterministic routers can reach saturation points comparable to adaptive routers.
Antibody-Based Therapies in Systemic Lupus Erythematosus (2009)

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that is characterized by pathologic manifestations in multiple organs and elevated morbidity. Traditional management of SLE has included the use of non-steroidal anti-inflammatory drugs, anti-malarials and immunosuppressive drugs such glucocorticoids, azathioprine, cyclophosphamide, and mycophenolate mofetil. Although many of these therapies have shown great efficacy, they often associate with adverse effects, due to their systemic activity. The development of safer therapies for SLE has led to recent emphasis on targeting selected pathways that can be important in the inflammatory response in SLE. In this context, the use of biological agents such as monoclonal antibodies has seen a rapidly increasing progress, and is poised to be some part of the clinical practice for SLE in a near future. This review provides an update on the ongoing clinical trials and the promise and obstacles in the use of biologics in SLE.
Accuracy and Repeatability of Automated Injector Versus Manual Administration of an MRI Contrast Agent—Results of a Laboratory Study (2017)

Injector administration of a magnetic resonance contrast agent minimally deviated from the target flow rate, whereas manual injection varied widely. Injector administration is more accurate and repeatable.
Electron spin polarization (CIDEP) and magnetic field effects (MFE) in systems involving sulfur-centered radicals (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron spin polarization (CIDEP) and magnetic field effects (MFE) in systems involving sulfur-centered radicalsS. N. Batchelor, C. W. M. Kay, K. A. McLauchlan, and M. T. YeungCite this: J. Phys. Chem. 1993, 97, 18, 4570–4572Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/j100120a002https://doi.org/10.1021/j100120a002research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effects of Yersinia enterocolitica infection on rabbit intestinal and colonic goblet cells and mucin: morphometrics, histochemistry, and biochemistry. (1991)

The effects of Yersinia enterocolitica on intestinal goblet cells were investigated in New Zealand white rabbits. Animals infected with Y enterocolitica were compared with weight matched and pair fed controls. Goblet cell hyperplasia developed in the distal small intestine of infected rabbits on day 1, in the mid small intestine on day 3, and in the upper small intestine on day 6. In all regions hyperplasia persisted throughout the 14 day study. The degree of hyperplasia was greater in the distal small intestine than the upper and mid regions. Goblet cells in the proximal colon of infected animals seemed to respond as those in the distal small intestine. Thus goblet cell hyperplasia developed more rapidly and to a greater extent in the ileocaecal region where mucosal injury was most severe. These changes resulted directly from Y enterocolitica infection since goblet cell numbers did not increase in pair fed controls. Histochemically, goblet cell mucins from infected rabbits were unchanged at either six or 14 days. Biochemical analysis, however, established that purified mucins from animals on day 6 after infection were less sialylated (in the small intestine) and more sulphated (in the small intestine and proximal colon). In addition, mucins from the distal small intestine and the proximal colon seemed to contain fewer but longer oligosaccharide chains.
Misclassification Is Likely in the Assessment of Mild Cognitive Impairment (2004)

We estimated the relative frequency of isolated memory impairment versus isolated and comorbid impairment in executive control function (ECF). One hundred and ninety-three noninstitutionalized residents of a single Comprehensive Care Retirement Community (mean age 79.2 years) were investigated. The subjects were tested with multiple measures of memory and ECF. Test scores were standardized to minimize scaling effects. 'Impairment' was defined as performance < or =1.5 standard deviations below the mean for the entire sample (i.e., a z score < or =-1.5). Disability was estimated as the sum of self-reported activities of daily living and instrumental activities of daily living. The cognitive test performance was significantly associated with functional impairment, independently of age. ECF and memory measures were significantly intercorrelated. Both were significantly and independently associated with disability ratings. 6-10% of the subjects had memory impairment; 25-35% of the memory-impaired subjects had comorbid ECF impairments. An additional 4-7% of the subjects had isolated ECF impairment. A significant fraction of the cases otherwise meeting the criteria for 'mild cognitive impairment' may have comorbid ECF impairment. This raises the issue of whether they might be more properly classified as 'demented'. In addition, isolated ECF impairment may affect almost as many persons as isolated memory impairment. Isolated ECF impairment is not consistent with the natural history of preclinical Alzheimer's disease, suggests other conditions, and can be disabling, independently of age and/or memory loss.
Haemostatic aspects of recombinant human erythropoietin in colorectal surgery (2002)

R-HuEPO given perioperatively significantly increased erythropoiesis in patients undergoing elective colorectal operations but had no influence on haemostatic activity.