gebhart/patrepeval huggingface dataset:
Wolff rearrangement of N-alpha-protected alpha-aminodiazoketones in presence of substituted phenol as a method for the synthesis of 2,4,5-trichlorophenyl esters of Fmoc-/Boc-/Z-beta-homoamino acids (2000)

Silver acetate catalyzed decomposition of the N-alpha-protected alpha-aminodiazoketones in the presence of 'substituted phenol' and triethylamine at 15 degrees C lead to 2,4,5-trichlorophenyl esters of Fmoc-/Boc-/Z-beta-homoamino acids in good yield and purity. Thus the homologation of alpha-amino acids to beta-homoamino acids with concomitant active esters formation has been achieved by this method.
Real-time monitoring of biliary transport in precision-cut liver slices (2018)

We present a polycarbonate (PC) microfluidic perfusion device for the cultivation of murine, precision-cut liver slices (PCLS). The design dimensions of this system are such that it is compatible with fluorescence microscopy for the observation of tissue and detection of fluorescently labeled markers. This system can thus be used for real-time monitoring of the uptake, metabolism and secretion of molecules by liver tissue from continuously flowing medium.
Analysis of Factors Predictive of Gastrointestinal Tract Leak in Laparoscopic and Open Gastric Bypass (2011)

We identified multiple factors associated with the higher risk of GI tract leak after gastric bypass. Surgeons should use this knowledge to counsel patients and possibly alter operative plans in high-risk patients to minimize this risk.
Solar paddle actuator for small satellites using shape memory alloy (II) (2001)

Quantitative experiments were conducted for a new type of actuator that uses shape memory alloy (SMA), which was developed for the solar paddle of small satellites and presented in the 9th ESMATS. The actuator can orient the solar paddle alone toward the sun, and is equipped with a counterweight to compensate for the rotating motion of the small satellite in microgravity. The actuator measures 100 mm in diameter and 127 mm in height, and weighs approximately 660 g including the counterweight (340 g). To rotate the solar paddle, we used six SMA springs, each of which has a cylindrical mirror in the rear in order to concentrate the sun's energy onto the spring. Drop shaft experiments were conducted to confirm the performance of the counterweight. Motion repetition experiments in vacuum were also conducted to investigate the degradation properties of the SMA. Ideas for improvement are proposed from the results.
Jun and Fos family protein expression in human breast cancer: correlation of protein expression and clinicopathological parameters. (2006)

Our results suggest an important role for JunB and Fral in the biological behavior of malignant breast tumors.
Xerostomia in the aged. (1989)

Xerostomia is a symptom associated with a variety of causes. Disorders in the production and transport as well as excessive depletion of saliva may lead to xerostomia. It is difficult to make any general statement about the functional significance of salivary gland changes associated with aging, as the clinical evidence is controversial and data from different studies do not encourage any uniform conclusion. Rational treatments of xerostomias may be performed casually (for example, withdrawal or exchange of drugs inhibiting salivary secretion), but will often only be practical as a symptomatic therapy. Special attention should be directed toward maintenance of adequate oral hygiene in order to prevent clinical complications such as increased dental caries, monilial infection, dysgeusia and tooth sensitivity, which are associated with xerostomia and are often observed in elderly xerostomic patients.
Entwicklung eines neuartigen Staustrahl‐Membranreaktors für die Zellkulturtechnik mittels CFD (2002)

No translation.
Transient Transgenesis in Xenopus laevis Facilitated by AAV-ITRs (2003)

A common approach to the study of gene function in Xenopus embryos is to ectopically express the gene of interest, or a mutant of that gene, by injecting either RNA or DNA, encoding the gene into early-stage embryos. Both of these approaches have disadvantages (). RNA injection results in little temporal or spatial control, as the RNA begins to be translated immediately following injection. In addition, RNA is unstable; therefore, transgene expression is relatively transient. In principle, DNA injections could ameliorate these problems. DNA does not begin to be translated until embryonic stage 8, at the mid-blastula transition, when zygotic genes begin to be expressed. Promoters can be utilized, which should enable more spatial and temporal control of gene expression, and DNA is more stable than RNA, prolonging the time frame in which transgenes can be expressed. However, for reasons that are not clear, expression of DNA plasmids following direct injection into embryos is extremely mosaic, and tissue specificity of promoters is often lost.
Chain Flexibility and the Segmental Dynamics of Polymers (2019)

Using molecular dynamics simulations, we examine the dynamics of a family of model polymers with varying chain length and torsional potential barriers. We focus on features of the dynamics of polymers that are seen experimentally but absent in simulations of freely rotating and freely jointed chains. The reduced effect of volume on the segmental dynamics with increasing chain length, a capacity for pressure densification, and the deviation from constant Johari-Goldstein relaxation time at a constant segmental relaxation time all have a common origin, torsional rigidity, and these effects become increasingly apparent for more rigid chains.
A superconducting antenna-coupled microbolometer for THz applications (2004)

In this paper we demonstrate a superconducting bolometer, coupled to a lithographic antenna. The detector is operated at 4.2 K, and has an electrical noise equivalent power (NEP) of 14 fW/Hz<sup>1/2</sup>. We note that this sensitivity is approaching the typical background noise limit for terrestrial observations. The attractive feature of antenna-coupled microbolometers is that the simple fabrication procedure allows straightforward scaling to arrays, multi frequency capability, as well as intrinsic polarization selectivity. These features potentially enable the remote detection of chemical or biological agents by measuring differential absorption with two or more bolometers coupled to antennas designed for the intended frequencies. The noise equivalent temperature difference attainable with these detectors is around 40 mK at 0.5 THz for an integration time of 1/30 s and 30 % bandwidth, which would enable unprecedented image quality in application to detection of concealed weapons. Although the devices require cooling to cryogenic temperatures, we note that compact, closed-cycle cryocoolers exist on the market, which removes the need for liquid cryogens and provides user-friendly operation.
ARE DIABETES MELLITUS AND CHROMOSOME 17Q12 GENETIC VARIANTS ASSOCIATED WITH PROSTATE CANCER AGGRESSIVENESS? (2009)

You have accessJournal of Urology1 Apr 2009ARE DIABETES MELLITUS AND CHROMOSOME 17Q12 GENETIC VARIANTS ASSOCIATED WITH PROSTATE CANCER AGGRESSIVENESS? Stacy Loeb, Brian T. Helfand, Donghui Kan, William B. Isaacs, and William J. Catalona Stacy LoebStacy Loeb More articles by this author , Brian T. HelfandBrian T. Helfand More articles by this author , Donghui KanDonghui Kan More articles by this author , William B. IsaacsWilliam B. Isaacs More articles by this author , and William J. CatalonaWilliam J. Catalona More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60292-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ARE DIABETES MELLITUS AND CHROMOSOME 17Q12 GENETIC VARIANTS ASSOCIATED WITH PROSTATE CANCER AGGRESSIVENESS?." The Journal of Urology, 181(4S), p. 102 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 102 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Stacy Loeb More articles by this author Brian T. Helfand More articles by this author Donghui Kan More articles by this author William B. Isaacs More articles by this author William J. Catalona More articles by this author Expand All Advertisement PDF downloadLoading ...
Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) of photodynamic therapy (PDT) outcome and associated changes in the blood-brain barrier following Pc 4-PDT of glioma in an athymic nude rat model (2012)

Introduction: Dynamic Contrast-Enhanced-Magnetic Resonance Imaging (DCE-MRI) appears to provide an unambiguous means of tracking the outcome of photodynamic therapy (PDT) of brain tumors with the photosensitizer Pc 4. The increase in Gd enhancement observed after Pc 4-PDT may be due to a temporary opening of the blood-brain-barrier which, as noted by others, may offer a therapeutic window. Methods: We injected 2.5 x 10<sup>5</sup> U87 cells into the brains of 9 athymic nude rats. After 8-9 days peri-tumor DCE-MRI images were acquired on a 7.0 T microMRI scanner before and after the administration of 150 μL Gd. DCE-MRI scans were repeated three times following Pc 4-PDT. Results: The average, normalized peak enhancement in the tumor region, approximately 30-90 seconds after Gd administration, was 1.31 times greater than baseline (0.03 Standard Error [SE]) prior to PDT and was 1.44 (0.02 SE) times baseline in the first Post-PDT scans (Day 11), a statistically significant (p ≈ 0.014, N=8) increase over the Pre- PDT scans, and was 1.38 (0.02 SE) times baseline in the second scans (Day 12), also a statistically significant (p ≈ 0.008, N=7) increase. Observations were mixed in the third Post-PDT scans (Day 13), averaging 1.29 (0.03 SE) times baseline (p ≈ 0.66, N=7). Overall a downward trend in enhancement was observed from the first to the third Post-PDT scans. Discussion: DCE-MRI may provide an unambiguous indication of brain tumor PDT outcome. The initial increase in DCE-MRI signal may correlate with a temporary, PDT-induced opening of the blood-brain-barrier, creating a potential therapeutic window.
Properties of Very Hot Nuclei Formed in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow/><mml:mrow><mml:mn>64</mml:mn></mml:mrow></mml:msup></mml:mrow><mml:mi>Zn</mml:mi><mml:mrow><mml:msup><mml:mrow><mml:mo>+</mml:mo></mml:mrow><mml:mrow><mml:mi>nat</mml:mi></mml:mrow></mml:msup></mml:mrow><mml:mi>Ti</mml:mi></mml:math>Collisions at Intermediate Energies (1996)

Formation and decay of hot nuclei have been studied in ${}^{64}\mathrm{Zn}{+}^{\mathrm{nat}}\mathrm{Ti}$ collisions between 35 and 79 MeV/nucleon. The mass and excitation energy of excited quasiprojectiles are reconstructed from the kinematical characteristics of their decay products. In central collisions, excitation energies larger than 10 MeV/nucleon are reached. Comparisons with theoretical predictions indicate that a fraction of the excitation energy is associated with an isotropic radial flow.
Synthesis of (3-Indolyl)heteroaromatics by Suzuki-Miyaura Coupling and Their Inhibitory Activity in Lipid Peroxidation (2003)

A variety of (3-indolyl)heteroaromatic compounds were synthesized by Suzuki-Miyaura coupling of 3-indolylboronic acid and halogenated heteroaromatics.2-(3-Indolyl)thiophene showed potent inhibitory activity against lipid peroxidation by rat liver microsome.Martefragin A ( 1) is an indole alkaloid isolated from a sea algae, Martensia fragilis Harvey, collected at Toyama Bay in Japan.
Media Content for "Analysis of Intonation Trajectories in Solo Singing" (2015)

Audio recording dataset and corresponding trajectory plots, as analysed in the paper "Analysis of Intonation Trajectories in Solo Singing" by Jiajie Dai, Matthias Mauch, Simon Dixon, all at Queen Mary University of London.
Role of axons in the regulation of P<sub>O</sub> biosynthesis by Schwann cells (1990)

The role of axons in the expression of the major myelin glycoprotein, P0, has been investigated using neuron/Schwann cell cultures. These cultures were either nonmyelinating or myelinating due to growth in defined medium or in medium containing serum and chick embryo extract, respectively. The neurons and Schwann cells used in the studies were derived from embryonic day 15 rat dorsal root ganglia (DRG), and the Schwann cells from these ganglia are shown not to synthesize appreciable levels of P0 prior to growth in culture. Myelinating cultures of Schwann cells and neurons grown together for 18-21 days synthesize P0 that is readily identified by immunoblotting. The nonmyelinating cultures, which do not assemble basal lamina, also synthesize P0 that is detectable by either [3H]mannose precursor incorporation or by immunoblotting. The steady-state level of P0 in the nonmyelinating cultures is less than that of the myelinating cultures, and the P0 that is synthesized by the former appears to be catabolized shortly after its biosynthesis. Since nonmyelinating Schwann cells synthesize P0 when in contact with neurites in vitro, we have examined the ability of such nonmyelinating cells to express the glycoprotein in vivo. Very little steady-state P0 is detected in immunoblots of the adult rat cervical sympathetic trunk (CST), a nerve in which approximately 99% of the axons are nonmyelinated. Similarly, the amounts of [3H]mannose and [3H]amino acids that are incorporated into newly synthesized P0 are much lower in the CST than in the adult sciatic nerve.(ABSTRACT TRUNCATED AT 250 WORDS)
Interleukin-15-Deficient Mice Develop Protective Immunity to<i>Toxoplasma gondii</i> (2004)

Previous studies have suggested an important role for interleukin-15 (IL-15) in resistance to and memory for Toxoplasma gondii infection. The studies presented here reveal that IL-15 is not required for infection-induced expansion of NK or CD8+ T cells. Furthermore, IL-15-/- mice develop long-term protective immunity to this pathogen.
Rogers Andrei — Matrix Analysis of International Population Growth and Distribution (1969)

Hecht Jacqueline. Rogers Andrei — Matrix Analysis of International Population Growth and Distribution. In: Population, 24ᵉ année, n°6, 1969. p. 1233.
Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein<i>O</i>-glycosylation extension (2016)

Invasive bladder tumours express the cell-surface Sialyl-Tn (STn) antigen, which stems from a premature stop in protein O-glycosylation. The STn antigen favours invasion, immune escape, and possibly chemotherapy resistance, making it attractive for target therapeutics. However, the events leading to such deregulation in protein glycosylation are mostly unknown. Since hypoxia is a salient feature of advanced stage tumours, we searched into how it influences bladder cancer cells glycophenotype, with emphasis on STn expression. Therefore, three bladder cancer cell lines with distinct genetic and molecular backgrounds (T24, 5637 and HT1376) were submitted to hypoxia. To disclose HIF-1α-mediated events, experiments were also conducted in the presence of Deferoxamine Mesilate (Dfx), an inhibitor of HIF-1α proteasomal degradation. In both conditions all cell lines overexpressed HIF-1α and its transcriptionally-regulated protein CA-IX. This was accompanied by increased lactate biosynthesis, denoting a shift toward anaerobic metabolism. Concomitantly, T24 and 5637 cells acquired a more motile phenotype, consistent with their more mesenchymal characteristics. Moreover, hypoxia promoted STn antigen overexpression in all cell lines and enhanced the migration and invasion of those presenting more mesenchymal characteristics, in an HIF-1α-dependent manner. These effects were reversed by reoxygenation, demonstrating that oxygen affects O-glycan extension. Glycoproteomics studies highlighted that STn was mainly present in integrins and cadherins, suggesting a possible role for this glycan in adhesion, cell motility and invasion. The association between HIF-1α and STn overexpressions and tumour invasion was further confirmed in bladder cancer patient samples. In conclusion, STn overexpression may, in part, result from a HIF-1α mediated cell-survival strategy to adapt to the hypoxic challenge, favouring cell invasion. In addition, targeting STn-expressing glycoproteins may offer potential to treat tumour hypoxic niches harbouring more malignant cells.
Hardware and software tracking for smart pen interface in wearable computing and mixed reality (2001)

This paper describes a system built for wearable computer and mixed reality applications that applies natural human computer interaction using a pen interface. The pen is fitted with hardware micro-accelerometers and interacts wirelessly with the host computer. This system is used to draw on a digital paper with digital ink and virtual objects. The tracking problem is solved using both inertial and visual methods.
Factores claves en las alianzas universidad - industria como soporte de la productividad en la industrial local: hacia un modelo de desarrollo económico y social sostenible (2007)

La investigación consistió en analizar ocho casos de innovación empresarial de cualquier sector, tanto en procesos y productos, desarrollados bajo la modalidad de alianza universidad-empresa, siguiendo para ello el modelo de Bruno y Vascocellos (2003). Mediante entrevistas estructuradas y grupos focales se siguió un procesamiento de datos cualitativo por medio del Etnographs, para identificar los aspectos claves en el establecimiento de la alianza y el desarrollo con éxito de los proyectos, de acuerdo con factores asociados con la institucionalidad, con temas organizacionales, la ejecución y desarrollo del proyecto y la creación de valor.
Perception of atrial fibrillation before and after radiofrequency catheter ablation: clinical relevance of asymptomatic arrhythmia recurrence based on a detailed analysis of more than 75.000 hours of ecg-recordings (2005)

Due to the investigative nature of AF catheter ablation, currently only highly symptomatic patients are treated. Remarkable success rates have been reported repeatedly. However, the follow up strategies measuring that outcome are largely based on symptomaticity. Therefore the present study aimed on analyzing the perception of AF in 114 pts. before and after a left atrial catheter ablation using the CARTO System. A digital 7-d-ECG was recorded prior to ablation, right after ablation, after 3 months, after 6 months and after 12 months. During the 7-d-ECG the pts. hourly registered quality and duration of any symptoms in a certain patient's log. Palpitation, dyspnoea, dizziness and chest pain were taken as surrogates of AF. Subsequently the amount of time with symptomatic AF, asymptomatic (ASYM) AF, symptomatic SR and ASYM SR was measured. Additionally the individual AF episode was classified as either symptomatic or ASYM. For more than 75000 hours of ECG recording symptoms and rhythm were correlated. Prior ablation 54% of the time in AF and 22% of the AF episodes were ASYM. After ablation the proportion of ASYM AF episodes increased from 22% to 53% of all AF episodes. Watching the individual patient ASYM AF was common in 65% of all pts. with AF before and after catheter ablation. Nevertheless, the percentage of pts. with only ASYM AF during the 7-d-ECG increased from 10% prior ablation to 36% 6 months after ablation. Pts. with highly symptomatic AF also exhibit a substantial amount of ASYM arrhythmia (54% of AF time, 22% of AF episodes). After ablation the amount of ASYM AF increased, with half of the episodes being ASYM. Furthermore, 36% of the pts. with AF recurrences at the 6 months follow up were completely ASYM during that 7-d-ECG. Our data show, that a judgement on the efficacy of percutaneus AF ablation based on patient's symptoms substantially overestimates the success rate. Objective follow up strategies, applied in a close manner, are needed for a through measurement of the real outcome.
E-Plane 3-Port X-Band Waveguide Circulators (Correspondence) (1963)

When a circulator is used with a parametric amplifier or maser, the noise contribution of the circulator may be reduced by cooling it in liquid nitrogen or liquid helium. Compact devices are required to put in the dewar and, depending on the microwave frequency, a compromise may be necessary in choosing between a compact stripline circulator and a comparatively bulky H-plane waveguide circulator, because waveguide feeds will have lower loss than coaxial line. This problem may be eased by using a very compact E-plane waveguide circulator, as shown in Fig. 1(a).
Odour thresholds of some organic compounds associated with food flavours (1963)

Abstract A simple technique for measurement of olfactory thresholds of odorous materials is described. Sensitivity and reproducibility of the method was good, but many precautions must be taken to insure reliability of results. Olfactory thresholds for a number of pure compounds, several of which were identified in potatoes, are presented. In general, sulphur compounds and short‐chain unsaturated aldehydes gave the lowest and highest thresholds, respectively. The thresholds of a homologous series of saturated aliphatic aldehydes decreased progressively with increase in chain length from C 5 to C 10 . Similar results were obtained with a series of unsaturated aldehydes. Thresholds of some of the more potent compounds were less than 0.1 of a part per 10 9 parts of water.
A novel impedance-tuned monopole antenna (2002)

The authors introduce the slot-tuned monopole antenna whose input impedance may be tuned using slots integrated within the antenna. The slots may be thought of as integrated coplanar-waveguide tuning stubs and may also be used to create a second impedance-tuned resonance. The ratio of the two impedance-tuned resonances can be adjusted by changing the dimensions of the antenna and slots. To illustrate the flexibility of the slot-tuned monopole antenna, two examples are presented. The first example shows how the insertion of a open circuited stub within the antenna can increase the resonant impedance of the monopole from approximately 35 /spl Omega/, which is typical to monopoles, to 50 /spl Omega/. The 50 /spl Omega/ input impedance is chosen because it is well matched to 50 /spl Omega/ coaxial lines. In actual applications, nearly any input impedance may be chosen. In the second example short and open circuited stubs were inserted in parallel and the dimensions of the antenna were adjusted to create an antenna with two impedance-tuned resonant frequencies with a frequency ratio of 1.5:1. For these tests, the antennas are fabricated on 10 mil thick substrate with /spl epsiv//sub r/=4. Simulations are performed using HP Momentum moment method software.
Development of an Abdominal Deformation Measuring System for Hybrid III Dummy (1994)

<div class="htmlview paragraph">A new abdominal deformation measuring system for Hybrid III dummy has been developed in order to evaluate the abdominal injury by using the dummy. From the dynamic abdominal deformation of the dummy, the abdominal compression velocity V, the compression ratio C, and the maximum value of the product VC, expressed as [VC]<sub>MAX</sub>, can be calculated.</div> <div class="htmlview paragraph">This abdominal deformation measuring system consists of an abdominal insert having the same compression characteristics as those of the human body, a dynamic deformation sensor, and an analysis program. The abdominal insert is made of elastic foam rubber and has a shape fitted to Hybrid III. The deformation sensor in a band shape is a thin stainless steel band with 25 strain gauges on it. Each strain gauge measures the curvature on its mounted position. Since the deformation sensor is located along the surface of the dummy abdomen, the sensor deforms as the dummy surface deforms. The analysis program calculates the distribution of curvature in the longitudinal direction of the sensor and the deformation of the abdomen during an impact. This system makes it possible to obtain the abdominal deformation in the impact tests using a cylindrical bar or a lap belt within an error of 10%.</div>