gebhart/patrepeval huggingface dataset:
SOME OBSERVED EFFECTS OF TEMPERATURE VARIATION ON SOIL BEHAVIOUR ---INTERNATIONAL CONFERENCE ON RHEOLOGY AND SOIL MECHANICS, 12-16 SEPTEMBER 1988, COVENTRY, UK (1988)

The results of tests in which samples were subjected to variation of temperature and control tests carried out at constant temperature are described and discussed. The temperature variations were imposed on samples of uniform sand and kaolin clay while undergoing drained and undrained creep, triaxial consolidation, and strain-controlled axial loading tests. In the drained tests water was expelled from the samples during periods of temperature increase and absorbed by the samples during periods of temperature decrease. In undrained tests the effects of temperature increase and decrease were to cause a rise and fall respectively in the pore water pressure. It is concluded that in order to avoid disturbance due to temperature changes samples retrieved from a site investigation should be transported to the laboratory in insulated containers and stored and tested at their in situ temperature.(a) for the covering abstract of this conference see IRRD 818664.
Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family. (1986)

The C proteins, C1 and C2, are major constituents of the heterogeneous nuclear RNA (hnRNA) ribonucleoprotein (hnRNP) complex in vertebrates. C1 and C2 are antigenically related phosphoproteins that are in contact with hnRNA in intact cells and bind to RNA tightly in vitro. A cDNA clone for the C proteins was isolated by immunological screening of a human lambda gt11 expression vector cDNA library with monoclonal antibodies. The lacZ-cDNA fusion protein is recognized by two different anti-C protein monoclonal antibodies. HeLa cell mRNA that was hybrid-selected with the cDNA clone (1.1 kilobases long) was translated in vitro and yielded both the C1 and C2 proteins (41 and 43 kDa, respectively). RNA blot analysis showed strong hybridization to two polyadenylylated transcripts, of about 1.4 kb and 1.9 kb, in human cells. Genomic DNA blot analysis showed multiple hybridizing restriction fragments in human and mouse, and homologous DNA sequences are found across eukaryotes from human to yeast. These findings suggest that the sequences encoding the hnRNP C proteins are members of a conserved gene family and they open the way for detailed molecular and genetic studies of these proteins.
Defining and Managing Expectations for Early Immunotherapy Cancer Trials (2015)

This review discusses the concept of expectations in assessing direct benefit to participants in phase I immunotherapy studies. With the push toward a faster assessment of clinical benefit or efficacy, limiting phase I studies to safety determination only is now viewed as obsolete and has been replaced by designs that draw attention to therapeutic benefit or efficacy. While this approach is touted as being more flexible in trial conduct, these designs are particularly problematic for immunotherapy studies. Defining and managing expectations is paramount on understanding the key axioms that emerge that include i) understanding bias in models and mechanistic results, ii) that no test is perfect, iii) it is difficult to select a good predictive biomarker in the absence of clinical data, even for targeted therapies, iv) markers predictive for monotherapy may not be predictive for combination therapy, and v) all about improved patient selection. Considering the heterogeneity of cancers and the immune response of the host, we think that immunotherapy should be developed in parallel with the identification of different clinico-pathological models of immune response to cancer. This approach would accomplish two important goals: 1) provide a biological understanding of the complete in vivo environment, thereby giving investigators the opportunity to optimize and maximize the effect of a specific immunotherapy agent and 2) addressing host environment issues simultaneously so that safety data and perceived benefit can be achieved more quickly.
Metabolic syndrome and adverse clinical outcomes in patients with bipolar disorder (2016)

Our results indicated that patients with comorbid bipolar disorder and MetS have more adverse clinical outcomes than those without, with more hospitalizations, severer tardive dyskinesia, poorer insight, poorer global function, and more impaired executive function. Monitoring MetS is crucial for assessing not only physical burden, but also psychiatric outcomes.
EEN REFEROTHEEK VOOR DE FEDERALE POLITIE Voorstel lastenboek met inbegrip van technische en humane aspecten (2006)

Evelien DE PAUW Sociaal assistent en licentiaat in criminologie, wetenschappelijk medewerkster, Universiteit Gent Paul PONSAERS Dr. in criminologie en directeur van Sociale Veiligheidsanalyse, Universiteit Gent Veronique DUMONT Sociologue, Doctorante et Assistante, Facultes Universitaires Notre-Dame de la Paix (FUNDP) Veronique LAURENT Sociologue et chercheuse, Facultes Universitaires Notre-Dame de la Paix (FUNDP) Claire LOBETMARIS Docteur en sciences du travail et Directrice de la CITA, Facultes Universitaires Notre-Dame de la Paix (FUNDP)
Low-temperature growth of polycrystalline Si and Ge films by photolytic laser-induced CVD (1982)

Laser-induced chemical vapor deposition (LCVD) of thin films is initiated by the pyrolysis or photodissociation of a polyatomic molecule near a gas-substrate interface. Photolytic LCVD is based upon the photodecomposition of the molecule which minimizes heating of the substrate. Recently, photodissociation of organometallic molecules with either a UV laser 1,2 or a lamp 3 has been used to deposit a variety of metal films. Also Hanabusa et al.
Fire test methodology for aerospace materials. 1: Thermal and smoke toxicological assessments of graphite/bismaleimide and graphite/epoxy systems (1980)

Both materials possess a high degree of thermal stability, with total heat release values being essentially identical under piloted ignition conditions over a range of 5 to 10 W/sq cm incident heat flux. The graphite/epoxy material had a tendency to auto-ignite at a lower heat flux (about 7 W/sq cm) and produced about 23 percent higher peak heat release rates, approximately 42 percent more carbon monoxide and considerably more smoke than the graphite/bismaleimide under conditions of piloted ignition. Toxicological potencies of smoke produced from the two composites were equivalent for 30 minute exposures. Potencies were also comparable to many common materials, such as wood. There was no evidence for the formation of an unusual toxicant nor for any short term post-exposure toxicological effects.
Local shell‐side heat transfer coefficients and pressure drop in a tubular heat exchanger with orifice baffles (1960)

Abstract By means of a moveable sensing probe previously described 2 local shell‐side heat transfer coefficients and friction losses were measured on a model tubular heat exchanger containing orifice baffles. The heat exchanger shell was 6‐in. nominal I.D. and 45 in. in length and contained four tubes in triangular arrangement passing through orifice baffles. Baffle hole diameters of 1‐/16, 1–2/16, 1–3/16, and 1–5/16 in. and baffle spacings of 4.0 and 9.0 in. were studied. Data were taken at several air flow rates for each of the four baffle hole diameters. The average heat transfer coefficient for the region between two central baffles was correlated with an empirical equation based on only two baffle spacings. An increase in the baffle‐to‐tube clearance caused a decrease in heat transfer. An increase in the baffle spacing also resulted in a decrease in heat transfer. Four flow zones in the baffle space are postulated from the analysis of Nusselt number distribution along the tube. The heat transfer characteristics in each of the four flow zones were analyzed in terms of the mechanism of the fluid flow. The pressure‐drop data were correlated in terms of an annular orifice coefficient of discharge and an orifice‐pressure‐drop function. As a result of this study a method was developed by which one can predict the average of the local coefficients at the baffle position from the knowledge of pressure drop across a single baffle.
Engagement of the Lewis X Antigen (CD15) Results in Monocyte Activation (1997)

We previously reported that monocyte adhesion to tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells increased expression of tissue factor and CD36 on monocytes. Using immunological cross-linking to mimic receptor engagement by natural ligands, we now show that CD15 (Lewis X), a monocyte counter-receptor for endothelial selectins may participate in this response. We used cytokine production as a readout for monocyte activation and found that CD15 cross-linking induced TNF-alpha release from peripheral blood monocytes and cells from the monocytic cell line MM6. Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-alpha mRNA after 3 to 4 hours of cross-linking. CD15 cross-linking also concomitantly increased interleukin-1 beta (IL-1 beta) mRNA, while no apparent change was observed in the levels of beta-actin mRNA, indicating specificity. To examine transcriptional regulation of cytokine genes by CD15 engagement, a CAT plasmid reporter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6. Subsequent cross-linking of CD15 increased CAT activity. CD15 engagement by monoclonal antibody also attenuated IL-1 beta transcript degradation, demonstrating that signaling via CD15 also had posttranscriptional effects. Nuclear extracts of anti-CD15 cross-linked cells demonstrated enhanced levels of the transcriptional factor activator protein-1, minimally changed nuclear factor-kappa B, and did not affect SV40 promoter specific protein-1. We conclude that engagement of CD15 on monocytes results in monocyte activation. In addition to its well-recognized adhesive role, CD15 may function as an important signaling molecule capable of initiating proinflammatory events in monocytes that come into contact with activated endothelium.
Slower step of the polycyclic aromatic hydrocarbons metabolism: kinetic data from microspectrofluorometric techniques. (1981)

A microspectrofluorometer has been used for kinetic studies of the decrease of benzo(a)pyrene and benzo(k)fluoranthene fluorescence. This decrease is observed for single living cells: L cells and human peripheral blood monocytes, after their incubation which culture medium containing these compounds and washing the petri dish with fresh medium. The entire fluorescence spectra is recorded at given time intervals in order to watch at some eventual spectral modification. The fluorescence decrease is monoexponential and its parameters are computed with a program based on the least squares fit method. Such determination shows no difference between the calculated rate constants of metabolisation for B(a)P and B(k)F and, as long as we consider L cells with a similar morphological shape, only statistical fluctuations of the rate constants of metabolism are observed. As compared, monocytes show faster kinetics of the decrease of the B(a)P intracellular fluorescence due to B(a)P metabolism, and also a more reached dispersion of the values of the rate constant than the one observed for L cells indicating some heterogeneity in the monocyte population of each donor.
Correlation of Alpha Activity between the Frontal and Occipital Cortex. (1992)

A method of modified coherence analysis was applied to the interpretation of EEG differences between the frontal and occipital cortex. This paper discusses a bidirectional communication model for the frontal and occipital cortex. Directed coherence method was used to analyze alpha activities over the scalp. The results show that both in the left and right hemisphere, slow waves in the alpha frequency band had high correlation in the frontal-occipital direction, and fast waves had high correlation in the occipital-frontal direction. It may suggest that the structure of information transmission is different for fast and slow waves of alpha rhythm.
Reversible Cardiac Dysfunction Associated with Interferon Alfa Therapy in AIDS Patients with Kaposi's Sarcoma (1989)

INTERFERON alfa is a leukocyte-derived glycoprotein with immunomodulatory, antiproliferative, and antiviral properties. Recombinant interferon alfa has been approved by the Food and Drug Administration for the treatment of Kaposi's sarcoma, hairy-cell leukemia, and condyloma acuminatum.1 , 2 In addition, interferon alfa has recently been shown to have antiretroviral effects in the early stages of human immunodeficiency virus type 1 (HIV-1) infection in patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi's sarcoma.3 , 4 Well-documented adverse effects of interferon therapy include a flu-like syndrome with fever, chills, and myalgias; malaise; anorexia; fatigue; bone marrow suppression; elevated levels of aminotransferase; and gastrointestinal discomfort. Neurologic and . . .
Ga Composition Dictates Macroscopic Photovoltaic and Nanoscopic Electrical Characteristics of Cu(In $_{1-X}$Ga$_X$)Se $_2$ Thin Films via Grain-Boundary-Type Inversion (2012)

The photovoltaic performance of solar cells, based on a Cu(In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-X</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">X</sub> )Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (CIGS) absorber layer, is directly correlated with Ga composition. We have used scanning capacitance microscopy and conducting probe atomic force microscopy (CP-AFM) to provide microscopic electrical characterization of CIGS films with different Ga content. We found p- to n-type inversion at grain boundaries of the polycrystalline CIGS film, especially for Ga-poor compositions. The fraction of grain boundaries undergoing inversion dramatically decreased for Ga compositions above x = 0.32, the composition corresponding to a sharp efficiency drop of the complete cells. CP-AFM measurements showed a marked current drop at grain boundaries as the Ga composition rose above x = 0.32.
Manganese regulates expression of manganese peroxidase by Phanerochaete chrysosporium (1990)

The appearance of manganese peroxidase (MnP) activity in nitrogen-limited cultures of Phanerochaete chrysosporium is dependent on the presence of manganese. Cultures grown in the absence of Mn developed normally and produced normal levels of the secondary metabolite veratryl alcohol but produced no MnP activity. Immunoblot analysis indicated that appearance of MnP protein in the extracellular medium was also dependent on the presence of Mn. Intracellular MnP protein was detectable only in cells grown in the presence of Mn. MnP mRNA was detected by Northern (RNA) blot analysis only in cells grown in the presence of Mn. If Mn was added to 4-day-old nitrogen-limited Mn-deficient cultures, extracellular MnP activity appeared after 6 h and reached a maximum after 18 h. Both actinomycin D and cycloheximide inhibited the induction of MnP activity by Mn. These results indicate that Mn, the substrate of the enzyme, is involved in the transcriptional regulation of the MnP gene.
Thiolato-technetium complexes. 2. Synthesis, characterization, electrochemistry, and spectroelectrochemistry of the technetium(III) complexes trans-[Tc(SR)2(DMPE)]+, where R is an alkyl or benzyl group and DMPE is 1,2-bis(dimethylphosphino)ethane (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiolato-technetium complexes. 2. Synthesis, characterization, electrochemistry, and spectroelectrochemistry of the technetium(III) complexes trans-[Tc(SR)2(DMPE)]+, where R is an alkyl or benzyl group and DMPE is 1,2-bis(dimethylphosphino)ethaneTakumi Konno, Jon R. Kirchhoff, William R. Heineman, and Edward DeutschCite this: Inorg. Chem. 1989, 28, 6, 1174–1179Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://doi.org/10.1021/ic00305a030RIGHTS & PERMISSIONSArticle Views52Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (776 KB) Get e-Alerts Get e-Alerts
Bradykinin regulation of airway submucosal gland secretion: role of bradykinin receptor subtype (1996)

To clarify the role of bradykinin receptor subtypes, we examined the effect of bradykinin on feline tracheal and human airway submucosal gland secretion using an isolated gland preparation. Bradykinin induced a significant increase in [3H]glycoconjugate secretion in a dose-dependent manner from isolated glands, which was significantly inhibited by D-Arg-(Hyp3, Thi5,8, D-Phe7)-bradykinin (the B2-receptor antagonist), whereas Des-Arg9-(Leu8)-bradykinin (B1-receptor antagonist) or indomethacin did not significantly alter it. Nitric oxide synthase inhibitor (nitro-L-arginine methyl ester) caused a significant inhibition of bradykinin-induced glycoconjugate secretion, which was reversed by the addition of L-arginine. Bradykinin evoked bidirectional current responses, and an initial inward current (Cl- current) was followed by an outward current (K+ current) of the acinar cells in a whole cell configuration by patch-clamp technique. Bradykinin induced an immediate increase in intracellular calcium concentration ([Ca2+]i) of the acinar cells followed by a prolonged plateau, and Ca2+ removal resulted in an initial increase alone. [Ca2+]i rise was significantly inhibited by the B2-receptor antagonist, whereas the B1-receptor antagonist did not significantly alter it. These findings suggest that B2-receptor stimulation and the resultant [Ca2+]i rise induced both mucus glycoprotein and electrolyte secretions, involving NO formation in airway submucosal gland cells.
New Mechanism of Antiferromagnetism (1959)

Received 8 September 1959DOI:https://doi.org/10.1103/PhysRevLett.3.414©1959 American Physical Society
Isomerism in Diels-Alder Adducts. V. The Products of Hydroxylation of Norbornylene (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsomerism in Diels-Alder Adducts. V. The Products of Hydroxylation of NorbornyleneHarold Kwart and William G. VosburghCite this: J. Am. Chem. Soc. 1954, 76, 21, 5400–5403Publication Date (Print):November 1, 1954Publication History Published online1 May 2002Published inissue 1 November 1954https://pubs.acs.org/doi/10.1021/ja01650a043https://doi.org/10.1021/ja01650a043research-articleACS PublicationsRequest reuse permissionsArticle Views280Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fuzzy associative learning of feature dependency for time series forecasting (2012)

Neuro-fuzzy system (NFS) has successfully been widely applied in solving problems across diverse fields, such as signal detection, fault detection, and forecasting. In recent years, many forecasting problems require the processing and learning of large number of dynamic data streams. Existing systems are inadequate in handling this type of complex problem. This paper presents a learning system that incorporates an evolving correlation-based feature selector to handle the high dimensionality of the data streams, and an evolving NFS to sequentially model and extract fuzzy knowledge about these data streams. The proposed system requires no prior knowledge of the data, reads the stream of data in a single pass, and accounts for the time-varying characteristics of the data. These three features allow the system to handle large and dynamic data. The effectiveness of the proposed system is validated on both synthetic and real-world problems. The experiments illustrate the viability of the proposed learning technique, and exemplifies how it can outperform existing NFS. Experiment on real-world stock price forecasting shows a remarkable reduction of error rate by 15.4%.
Cellular targets and host genes in multistage carcinogenesis. (1984)

Recent studies indicate that although cellular DNA is the critical target in the action of initiating carcinogens, specific membrane-associated receptors mediate the actions of certain tumor promoters. A stereochemical model is presented to explain how three different types of tumor promoters (phorbol esters, indole alkaloids, and polyacetates) can interact with the same class of cellular receptors. Multistage chemical carcinogenesis might involve progressive alterations in the expression of cellular DNA sequences homologous to oncogenes and regulatory sequences in certain retroviruses. We found that the oncogene c-mos is not rearranged or expressed in a series of carcinogen-transformed murine C3H 10T112 cells. These cells do express, however, a unique set of poly(A)+ RNAs that contain sequences homologous to the Moloney leukemia virus long terminal repeat sequence. Studies are in progress to determine the significance of this finding with respect to the carcinogenic process.
Development of OTN Near Infrared Bioimaging System Based on Ceramic Nanoparticles (2015)

希土類イオンを含有するセラミックスの可視光から近赤外光に及ぶ発光は，従来レーザーロッドやディスプレイ用の発光体として応用されてきた。一方，近赤外波長域は生体の光損失が少なく，透明度の高い波長域として知られているため，近赤外の発光を利用したバイオイメージングが注目を浴びている。著者らは希土類イオン含有セラミックスナノ粒子を生体機能化することで，生体の高い透光性を活かした近赤外蛍光バイオイメージングに応用するとともに，この波長域，とくに1,000 nmを超える（OTN）波長域での蛍光バイオイメージングシステムの開発に取り組んできた。本稿では，蛍光体としての希土類イオン含有セラミックスナノ粒子を起点とした小動物の近赤外蛍光バイオイメージングシステムの開発について概説する。
New Unsymmetrical Difluoroaromatic Compounds and Estimation of Their Reactivities in Nucleophilic Substitution. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.