gebhart/patrepeval huggingface dataset:
Antibioticamodelle, 7. Diastereoselektiver Aufbau eines Rhodomycinon‐Modells aus D‐Glucose (1986)

Abstract Aus D‐Glucose läßt sich die Hex‐2‐enopyranosid‐4‐ulose 8 darstellen, deren Diels‐Alder‐Reaktion mit Butadien unter milden Bedingungen diastereoselektiv zum Cyclohexan‐überbrückten Pyranon 12 führt. Eine entsprechende Verknüpfung von 8 mit Isopren verläuft regioselektiv zum Derivat 11 . Die aus 12 gewonnene Iodmethylen‐Komponente 13 wird stereoselektiv zum Alkohol 15 reduziert; in basischem Medium fällt vornehmlich das trans ‐verknüpfte Isomer 17 an. Durch klassische Umsetzung mit Silberfluorid/Pyridin kann aus 16 der exocyclische Enolether 18 dargestellt werden. Seine Quecksilbersalz‐vermittelte Solvolyse ergibt in Übereinstimmung mit den Baldwin ‐Regeln einen stereospezifischen Ringschluß unter Chiralitätsübertragung zum carbobicyclischen Keton 20 , das als kristallines Diacetat 21 isoliert wird. Durch Grignard‐Ethylierung wird stereospezifisch das kristalline Triol 23 erhalten, das ein B‐A‐Modellsystem des β‐Rhodomycinons darstellt.
Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer (2006)

In a pioneer study, we showed 10 years ago that enhanced tissue levels of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9 in gastric cancers, as determined by zymography, were related with worse overall survival of the patients. To corroborate these observations, we now assessed MMP-2 and MMP-9 with new techniques in an expanded group of gastric cancer patients (n = 81) and included for comparison MMP-7, MMP-8 and the tissue inhibitors of MMPs, TIMP-1 and -2. All MMPs and TIMP-1 were significantly increased in tumour tissue compared to normal gastric mucosa. Matrix metalloproteinase-7, -8 and -9, and the TIMPs showed some correlations with the clinicopathologic parameters TNM, WHO and Laurén classification, but their levels were not related with survival. Regardless of the determination method used, that is, enzyme-linked immunosorbent assay or bioactivity assay, an enhanced tumour MMP-2 level did not show a significant correlation with any of the clinicopathological parameters, but was confirmed to be an independent prognostic factor in gastric cancer.
Observations of a Thunderstorm Generated Gust Compared with Solitary Wave Theory (1988)

Abstract : Observations suggest that solitary and other nonlinear waves might be a source of wind shear hazard to safe flight. A derivation of the Benjamin- Davis-Ono (BDO) equation by a perturbation method is reviewed and extended to the case in which the fluid is in sheared flow. For nonsheared flows, our solution for the upper layer differs markedly from Benjamin's, which doesn't satisfy his specified boundary conditions. The internal steady-state solitary wave, described by the solution of the BDO equation, is compared with a boundary layer solitary wave observed with NSSL's Doppler radar, and a 444-m-tall instrumented tower. Wave-induced vertical transport of the horizontal momentum of the strongly sheared ambient air contributed much to the observed wind perturbations and horizontal wind shear. It is shown that agreement between the theoretical results of the weakly nonlinear theory of BDO and observations of wind and temperature at the surface is coincidental because wave advection and frictional drag markedly affect wave properties. Only tall tower and Doppler radar measurements above the ground provided the necessary data to determine that the observed solitary wave was strongly nonlinear, and that it trapped thunderstorm outflow, which leaked out the rear of the wave. Wave amplitude data, for above (i.e., < or approx. = 200 m) the ground, show fairly good agreement with numerical results from strongly nonlinear theory. Wind shear produced by the solitary wave appears to be significant, even though it is 60 km from the storm that initiated it.
Cell Response to the Exposure to Chitosan–TPP//Alginate Nanogels (2011)

Hydrophilic nanocarriers formed by electrostatic interaction of chitosan with oppositely charged macromolecules have a high potential as vectors in biomedical and pharmaceutical applications. However, comprehensive information about the fate of such nanomaterials in biological environment is lacking. We used chitosan from both animal and fungal sources to form well-characterized chitosan-pentasodium triphosphate (TPP)//alginate nanogels suitable for comparative studies. Upon exposure of human colon cancer cells (HT29 and CaCo2), breast cancer cells (MDA-MB-231 and MCF-7), glioblastoma cells (LN229), lung cancer cells (A549), and brain-derived endothelial cells (HCEC) to chitosan-(TPP)//alginate nanogels, cell type-, nanogel dosage-, and exposure time-dependent responses are observed. Comparing chitosan-TPP//alginate nanogels prepared from either animal or fungal source in terms of nanogel formation, cell uptake, reactive oxygen species production, and metabolic cell activity, no significant differences become obvious. The results identify fungal chitosan as an alternative to animal chitosan in particular if biomedical/pharmaceutical applications are intended.
A new live-attenuated polio vaccine constructed by rational design improves safety by preventing reversion to virulence (2020)

Variant calls for the in vivo and in vitro studies of virus diversity and genetic stability reported in the manuscript, "A new live-attenuated polio vaccine constructed by rational design improves safety by preventing reversion to virulence", by Yeh, et al.
ChemInform Abstract: Nucleotides. Part 38. Syntheses and Characterization of Phosphorothioate Analogues of (2′‐5′)Adenylate Dimer and Trimer and Their 5′‐O‐Monophosphates. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interpretation of static-weighting H-infinity design approaches for interval plants (2003)

This paper takes advantage of the critical direction theory to select a meaningful static weight for the H/sub /spl infin// design of robust controller for parametrically uncertain plants. The mechanisms leading to conservatism in an earlier approach utilizing a constant overbounding uncertainty bound are analyzed first; then, an alternative less conservative uncertainty bound is presented. Finally, an example is used to illustrate that the proposed approach can substantially increase the stabilizable uncertainty level.
RE: THE ROLE OF COMPUTERIZED TOMOGRAPHY IN THE EVALUATION OF COMPLICATIONS AFTER LAPAROSCOPIC UROLOGICAL SURGERY (1998)

No AccessJournal of UrologyClinical Urology: Letters to the Editor1 May 1998RE: THE ROLE OF COMPUTERIZED TOMOGRAPHY IN THE EVALUATION OF COMPLICATIONS AFTER LAPAROSCOPIC UROLOGICAL SURGERY J.A. Cadeddu, F. Regan, L.R. Kavoussi, and R.G. Moore J.A. CadedduJ.A. Cadeddu More articles by this author , F. ReganF. Regan More articles by this author , L.R. KavoussiL.R. Kavoussi More articles by this author , and R.G. MooreR.G. Moore More articles by this author View All Author Informationhttps://doi.org/10.1097/00005392-199805000-00070AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "RE: THE ROLE OF COMPUTERIZED TOMOGRAPHY IN THE EVALUATION OF COMPLICATIONS AFTER LAPAROSCOPIC UROLOGICAL SURGERY." The Journal of Urology, 159(5), pp. 1645–1646 References 1 : Comparison of open and laparoscopic live donor nephrectomy. Ann. Surg.1997; 226: 483. Google Scholar 2 : Living related and unrelated donors for kidney transplantation. A 28-year experience. Ann. Surg.1995; 222: 353. Google Scholar 3 : Comparison of laparoscopic live donor nephrectomy versus the standard open approach. Transplant. Proc.1997; 29: 138. Google Scholar © 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 159Issue 5May 1998Page: 1645-1646 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information J.A. Cadeddu More articles by this author F. Regan More articles by this author L.R. Kavoussi More articles by this author R.G. Moore More articles by this author Expand All Advertisement PDF DownloadLoading ...
The Ester Group:  How Hydrofluoroalkane-philic Is It? (2007)

Pressurized metered-dose inhalers (pMDIs) have been recognized as potential devices for the delivery of systemically acting drugs, including biomolecules, to and through the lungs. Therefore, the development of novel excipients capable of imparting stability to suspension formulations in hydrofluoroalkane (HFA) propellants is of great relevance because many of the drugs of interest are poorly soluble in HFAs. In this work, we use ab initio calculations and chemical force microscopy (CFM) to determine the HFA-philicity of the biodegradable and biocompatible ester moiety quantitatively. The complementary information obtained from the binding energy calculations and adhesion force measurements are used to gain microscopic insight into the relationship between the chemistry of the moiety of interest and its solvation in HFA. A lactide (LA)-based copolymer surfactant was synthesized and characterized, and its ability to stabilize a dispersion of micronized budesonide in HFA227 was demonstrated. These results corroborate the ab initio calculations and CFM and show that the LA-based moiety is a suitable candidate for enhancing the stability of dispersions in HFA-based pMDIs.
A Twenty-Five Year Experience in Managing Children Who Had Sustained Electrical Burns of the Oral Commissure (2002)

Journal Article A Twenty-Five Year Experience in Managing Children Who Had Sustained Electrical Burns of the Oral Commissure Get access T. T. Huang, MD, T. T. Huang, MD 1University of Texas Medical Branch and Shriners Burns Institute, Galveston, TX Search for other works by this author on: Oxford Academic Google Scholar Y. Nakamura, MD, MD, Y. Nakamura, MD, MD 1University of Texas Medical Branch and Shriners Burns Institute, Galveston, TX Search for other works by this author on: Oxford Academic Google Scholar D. N. Herndon, MD, FACS D. N. Herndon, MD, FACS 1University of Texas Medical Branch and Shriners Burns Institute, Galveston, TX Search for other works by this author on: Oxford Academic Google Scholar The Journal of Burn Care & Rehabilitation, Volume 23, Issue suppl_2, March-April 2002, Page S68, https://doi.org/10.1097/00004630-200203002-00056 Published: 01 March 2002
Mutations in transmembrane domains 1, 4 and 9 of the <i>Plasmodium falciparum</i> chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine (2007)

In the article by Cooper et al. (2007) an error appeared in Fig. 8. In TMD 4 of PfCRT, amino acids 168-177 were numbered incorrectly. The corrected figure is shown below.
Reply to ‘‘Lifetime broadening in bulk photoemission spectroscopy’’ (1993)

The comment by Starnberg, Brauer, and Nilsson qualitatively identifies the final-state lifetime as the cause of the ``anomalous'' photoemission broadening, but it neglects the linear energy dependence of the final-state broadening whose effect is of the same magnitude as the purely geometrical contributions.
Erratum: Magnetic susceptibility of Nd(BrO3)3 ⋅ 9H2O single crystal: Effects of the crystal field and calculation of the electrostatic crystal field parameters [J. Chem. Phys. <b>8</b> <b/>, 3753 (1984)] (1986)

First Page
Bmoo FIBMP-I: A New Fibrinogenolytic Metalloproteinase from<i>Bothrops moojeni</i>Snake Venom (2012)

A new fibrinogenolytic metalloproteinase (Bmoo FIBMP-I) was purified from Bothrops moojeni snake venom. This enzyme was isolated through a combination of three chromatographic steps (ion-exchange, molecular exclusion, and affinity chromatography). Analyses by reverse phase chromatography, followed by mass spectrometry, showed the presence of enzyme isoforms with average molecular mass of 22.8 kDa. The SDS-PAGE analyses showed a single chain of 27.6 kDa, in the presence and absence of reducing agent. The protein has a blocked N-terminal. One of the peptides obtained by enzymatic digestion of a reduced and S-alkylated isoform was completely sequenced by mass spectrometry (MS/MS). Bmoo FIBMP-I showed similarity with hemorrhagic factor and several metalloproteinases (MP). This enzyme degraded Aα-chain faster than the Bβ-chain and did not affect the γ-chain of bovine fibrinogen. The absence of proteolytic activity after treatment with EDTA, together with the observed molecular mass, led us to suggest that Bmoo FIBMP-I is a member of the P-I class of the snake venom MP family. Bmoo FIBMP-I showed pH-dependent proteolytic activity on azocasein, but was devoid of coagulant, defibrinating, or hemorrhagic activities. The kinetic parameters of proteolytic activity in azocasein were determined (V max = 0.4596 Uh(-1)nmol(-1) ± 0.1031 and K m = 14.59 mg/mL ± 4.610).
Polymer Synthesis in Ionic Liquids (2002)

This chapter contains sections titled: Introduction Acid-catalyzed Cationic Polymerization and Oligomerization Free Radical Polymerization Transition Metal-catalyzed Polymerization Ziegler–Natta Polymerization of Ethylene Late Transition Metal-catalyzed Polymerization of Ethylene Metathesis Polymerization Living Radical Polymerization Preparation of Conductive Polymers Conclusions
ChemInform Abstract: Planar Tether Control Groups and π‐Facial Selectivity: Intramolecular Cycloadditions for Polycyclic Systems. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bridges To Engineering Research 2020: A National Workshop For Engineering Research Partnerships (2020)

15 corporations; 62 faculty and
Furosemide Promotes Patent Ductus Arteriosus in Premature Infants with the Respiratory-Distress Syndrome (1983)

Furosemide stimulates the renal synthesis of prostaglandin E2, a potent dilator of the ductus arteriosus. We administered this drug to 33 premature infants with the respiratory-distress syndrome, to determine whether it increased the incidence of patent ductus arteriosus. Chlorothiazide, a diuretic that does not stimulate prostaglandin E synthesis, was used as the control drug in 33 other infants. During the study, the incidence of patent ductus arteriosus was significantly higher (P less than 0.02) in the furosemide group (18 of 33 infants) than in the chlorothiazide group (8 of 33). Eleven infants in the furosemide group and seven in the chlorothiazide group required ductal ligation (P greater than 0.2). An additional six infants (all from the furosemide group) who did not have evidence of a patent ductus during the study were later found to have one. Overall survival was 76 and 61 per cent in the furosemide and chlorothiazide groups, respectively (P greater than 0.2). Small (less than twofold) increases in the urinary excretion of prostaglandin E were seen after the initial dose of both drugs. When the analysis was repeated after the fifth day of life, prostaglandin E excretion tripled after furosemide administration, whereas no increase occurred with chlorothiazide. We conclude that furosemide increases the incidence of patent ductus arteriosus in premature infants with the respiratory-distress syndrome, probably through a prostaglandin-mediated process.
X-Ray crystal structure of (+)-crispatanolide, a novel eudesmane-type sesquiterpene δ-lactone from Makinoa crispata(liverwort) (1980)

From the liverwort, Makinoa crispata(Dilaenaceae), a novel eudesmane-type sesquiterpene δ-lactone, crispatanolide, was isolated and its structure was established to be 2,4-cycloeudesman-14,7-olide (1) by X-ray analysis.
Third Generation of the Cp‘−P Ligand:  Highly Stereoselective Control of Central Chirality Arising at a Metal Center. (2000)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionThird Generation of the Cp'−P Ligand: Highly Stereoselective Control of Central Chirality Arising at a Metal Center.Yasutaka Kataoka, Yoko Iwato, Tsuneaki Yamagata, and Kazuhide TaniCite this: Organometallics 2000, 19, 9, 1810Publication Date (Web):March 24, 2000Publication History Published online24 March 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/om000168thttps://doi.org/10.1021/om000168tcorrectionACS PublicationsCopyright © 2000 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views194Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (11 KB) Get e-Alertsclose Get e-Alerts
Improved high-temperature operation of InGaAs/AlGaAs LOC SQW diode lasers by incorporation of short-period superlattice quantum-well barriers (2001)

InGaAs/AlGaAs large optical cavity (LOC) single quantum well (SQW) lasers emitting at 980nm were grown incorporating an AlGaAs/GaAs short-period superlattice layer next to the quantum well in order to improve the carrier confinement and thus high-temperature operation. Symmetric and asymmetric structures have been realized. High characteristic temperatures T0 above 300K between 20#C and 50#C operating temperature were measured for the symmetric structures without deterioration of the internal quantum efficiencies (> 90%) and low intrinsic losses (about 1cm-1). The improvement in the characteristic temperature is mainly attributed to the reduced thermionic emission of the carriers out of the quantum well due to the large effective barrier height of the short-period superlattice. Caused by the incorporation of the short-period superlattice the devices showed a higher series resistance, which could be lowered by switching to asymmetric structures. These asymmetric devices had unchanged high internal quantum efficiencies and low intrinsic losses but lower characteristic temperatures of about 250K.
A 32-Gb/s On-Chip Bus With Driver Pre-Emphasis Signaling (2009)

This paper describes a differential current-mode bus architecture based on driver pre-emphasis for on-chip global interconnects that achieves high-data rates while reducing bus power dissipation and improving signal delay latency. The 16-b bus core fabricated in 0.25-mum complementary metal-oxide-semiconductor (CMOS) technology attains an aggregate signaling data rate of 32 Gb/s over 5-10-mm-long lossy interconnects. With a supply of 2.5 V, 25.5-48.7-mW power dissipation was measured for signal activity above 0.1, equivalent to 0.80-1.52 pJ/b. This work demonstrates a 15.0%-67.5% power reduction over a conventional single-ended voltage-mode static bus while reducing delay latency by 28.3% and peak current by 70%. The proposed bus architecture is robust against crosstalk noise and occupies comparable routing area to a reference static bus design.
The correction of high myopia. (1992)

There are welcome signs that the ophthalmic profession is at long last facing up to its responsibilities to those unfortunate enough to suffer from high myopia. At this time, it is my opinion that the safest and most effective option is the use of the ZB5M anterior chamber implant inserted into phakic eyes, the updated technique devised by Baikoff and Domilens. In the long term, the future probably lies with the use of corneal inlays using a high refractive index thermoplastic such as polysulfone.
Deoxyribonucleic Acid Similarities among Pseudomonas Species (1989)

Deoxyribonucleic acid similarity experiments in which the S1 nuclease methodology was used were performed on strains of Pseudornonas species, including some that had not been previously subjected to similarity measurements. The results obtained with this technique confirmed and expanded previous observations on the low levels of deoxyribonucleic acid similarity among species of the genus as determined by membrane competition experiments. A general discussion of the results and nomenclatural status of some of the species is included.
Surface-stoichiometry dependence of As2 desorption and As4 ‘‘reflection’’ from GaAs(001) (1989)

Using real-time reflection mass spectrometry, we have measured the temperature dependence of As2 desorption and As4 ‘‘reflection’’ from a GaAs(001) surface. The measurements agree well with the second-order flux-balance equation expected to govern surface stoichiometry, and determine its rate constant. Using that rate constant, the equation associates physically reasonable surface stoichiometries with the various well-known GaAs(001) surface reconstructions, and is strikingly consistent with measurements of the times for surface reconstruction changes in the absence of an As ambient.
A Tripropylene Glycol Diacrylate-based Polymeric Support Ink for Material Jetting (2017)

Support structures and materials are indispensable components in many Additive Manufacturing (AM) systems in order to fabricate complex 3D structures. For inkjet-based AM techniques (known as Material Jetting), there is a paucity of studies on specific inks for fabricating such support structures. This limits the potential of fabricating complex 3D objects containing overhanging structures. In this paper, we investigate the use of Tripropylene Glycol Diacrylated (TPGDA) to prepare a thermally stable ink with reliable printability to produce removable support structures in an experimental Material Jetting system. The addition of TGME to the TPGDA was found to considerably reduce the modulus of the photocured structure from 575 MPa down to 27 MPa by forming micro-pores in the cured structure. The cured support structure was shown to be easily removed following the fabrication process. During TG-IR tests the T5% temperature of the support structure was above 150 °C whilst the majority of decomposition happened around 400 °C. Specimens containing overhanging structures (gate-like structure, propeller structure) were successfully manufactured to highlight the viability of the ink as a support material.
Retrospective analysis of phone queries to an epilepsy clinic hotline. (2014)

We undertook a retrospective study of 5,189 telephone calls made between January 2004 and June 2011 through our adult epilepsy clinic hotline to a single epileptologist initially and two epileptologists from June 2010 onwards. The majority of calls were made by patients themselves (72%), followed by family members (16%) and health care providers (11%). Half of the calls originated from outside the city limits. Most were related to medication (25%), notification of seizures (23%), appointments or tests (12%), and side effects (9%). Half of the workload was generated by 10% of patients. The hotline service appears to respond to needs, with most calls requiring rapid intervention. It is desirable to develop novel approaches to address the needs of high-frequency callers.