gebhart/patrepeval huggingface dataset:
Decrease in Na+,K+-ATPase activity and [3H]ouabain binding sites in sarcolemma prepared from hearts of spontaneously hypertensive rats. (1983)

Na+,K+-ATPase activity, phosphorylation, and [3H]ouabain binding in sarcolemma isolated from spontaneously hypertensive rat (SHR) hearts were compared to the same parameters in sarcolemma from normotensive rat (WKY) hearts. Sarcolemma prepared from SHR heart contained significantly less ouabain-inhibitable ATPase activity than sarcolemma from WKY heart. No significant differences in sarcolemmal protein content or recovery were noted between the two groups. The numbers of phosphorylation sites and ouabain binding sites were lower for SHR hearts than for WKY hearts. The KD values for ouabain binding were the same (0.30 muM) in cardiac sarcolemma of SHR and WKY. The I50 values for inhibition by ouabain of Na+,K+-ATPase were also the same for both groups (SHR = 49 microM; WKY = 44 microM). These data suggest that the decrease of cardiac sarcolemmal Na+,K+-ATPase activity in SHR hearts is due to a decrease in the number of active sites.
In vitro selection of tumor cells obtained from patients with ovarian carcinoma. A cytogenetic study. (1982)

Five cases of ovarian carcinoma were studied cytogenetically. Using cell cultures derived from ascitic effusions, two cytogenetically distinguishable cell populations were found in each case: one in the diploid range, and one in the heteroploid range. Selection in vitro occurred against the heteroploid cells. As a result of these findings, it is suggested that chromosome analyses can diminish the possibility of overlooking cellular changes leading to cell populations not representative of the carcinoma in vivo.
Plastic split alignment sleeves for single-mode fiber connection of MU- and SC-type ferrules (2001)

Split alignment sleeves for the single-mode optical-fiber connection of MU and SC-type ferrules were successfully fabricated for the first time with a precise injection-molding technique using a thermosetting epoxy resin. The optimum inner radii of the plastic sleeves were determined with a view to realizing both suitable gauge retention forces for the ferrules and a small fiber offset of 1 μm between them. The adapters incorporating the plastic sleeves showed excellent performance with an average connection loss of 0.09 dB and a return loss of >50 dB.
Reducing number fluctuations of ultracold atomic gases via dispersive interrogation (2012)

We have used dispersive laser probing to follow the central density evolution of a trapped atomic cloud during forced evaporative cooling. This was achieved in a heterodyne detection scheme. We propose to use this as a nondestructive precursor measurement for predicting the atom number subsequent to evaporation and provide a simple experimental demonstration of the principle leading to a conditional reduction of classical number fluctuations.
Strange Dynamics of a Dynamic Cytoskeleton (2007)

A novel physical perspective of molecular interactions within the cytoskeleton of the airway smooth muscle cell may help to explain why the most efficacious of all known bronchodilatory agencies-a simple deep inspiration-becomes abrogated during the spontaneous asthma attack and leads thereby to excessive airway narrowing. This perspective invites us to think of airway smooth muscle not only biochemically as a nidus of traditional cell signaling and immune modulation or mechanically as a motor for generation of active forces but also physically as a phase of soft condensed matter that can restrict airway stretch and dilation. This is perhaps a risky path and is surely an unconventional one, but it is where the trail of evidence leads. This line of investigation is unlikely by itself to provide an asthma cure but will lead to a new conceptual framework without which novel pathways, unsuspected phase transitions, and unanticipated mechanisms of action of target molecules would almost surely remain hidden. Glassy dynamics of the cytoskeleton are likely to be important in a wide range of biological functions and disease processes, but had it not been for their preeminent role in bronchospasm, they might never have been discovered.
Synthesis of [<sup>14</sup>C]‐labelled pelrinone (1987)

Abstract [ 14 C]Pelrinone (1,4‐dihydro‐2‐methyl‐4‐oxo‐6[(3‐pyridinylmethyl)‐amino]‐5‐pyrimidine‐[ 14 C]‐carbonitrile hydrochloride; AY‐28,768 hydrochloride), a potent inotropic agent, was prepared by reacting chloroacetic acid with [ 14 C]sodium cyanide to give the labelled cyanoacetic acid. The acid was esterified, converted to the bis‐S‐methyl compound, condensed with acetamidine hydrochloride, coupled with 3‐aminomethylpyridine, and treated with methanolic hydrochloric acid. Two batches of [ 14 C]pelrinone were produced, giving a combined overall yield of 15.6% from [ 14 C]sodium cyanide (sp. act. 66.2 ± 1.5 and 64.2 ± 1.9 μCi/mg; 98.8 and 98.0% radiochemical purity, respectively).
Assessment of the 60 Km Rapid Update Cycle (RUC) with Near Real-Time Aircraft Reports (1998)

NASA is developing the Center-TBACON Advisory System (CTAS), a set of Air Traffic Management (ATM) Decision Support Tools (DST) to enable controllers to increase airspace capacity and flight efficiency. A crucial component of the CTAS, or any ATM DST, is the computation of the time-of-flight of aircraft along flight path segments which requires accurate knowledge of the wind through which the aircraft are flying. CTAS currently uses wind information from the Rapid Update Cycle (RUC), a numerical prediction model run operationally by the National Weather Service (NWS) National Center for Environmental Prediction (NCEP). There exists near real-time wind observations from commercial aircraft that can be used to increase the accuracy of the RUC wind forecasts via the FAA Integrated Terminal Weather System (ITWS) Terminal Winds (TW) algorithm. This report presents a study based on the application of the ITWS TW algorithm as an improvement to the baseline RUC product. Terminal Winds generally does not support the full Center airspace; the domain of the prototype MIT/LLITWS TW system was increased to cover the Denver Center airspace to support this study. This study has three goals: 1) determine the errors in the baseline 60-kilometer resolution RUC forecast wind fields relative to the needs of en route DSTs such as CTAS; 2) determine the benefit of using the TW algorithm to refine the RUC forecast wind fields with near real-tlme Meteorological Data Collection and Reporting System (MDCRS) aircraft reports, and 3) identify factors that influence wind field errors in order to improve accuracy and estimate errors in real time. The data for this study were collected over a one-year period for the Denver Center airspace and over one miIlion verification observations were used. This study is part of a larger effort funded by NASA which includes the NOAA/FSL.
Systems Support for Preemptive Disk Scheduling (2005)

Allowing higher-priority requests to preempt ongoing disk IOs is of particular benefit to delay-sensitive and real-time systems. In this paper, we present semi-preemptible IO, which divides disk IO requests into small temporal units of disk commands to improve the preemptibility of disk access. We first lay out main design strategies to allow preemption of each component of a disk access-seek, rotation, and data transfer, namely, seek-splitting, JIT-seek, and chunking. We then present the preemption mechanisms for single and multidisk systems-JIT-preemption and JIT-migration. The evaluation of our prototype system showed that semi-preemptible IO substantially improved the preemptibility of disk access with little loss in disk throughput and that preemptive disk scheduling could improve the response time for high-priority interactive requests.
Hydrothermal Syntheses:  A Route to the Stepwise Condensation of Reduced Keggin Polyanions. From Reduced β-[H<i><sub>m</sub></i>SiMo<sub>12</sub>O<sub>40</sub>]<i><sup>n</sup></i><sup>-</sup> Monomers to Bicapped Dimerized [Si<sub>2</sub>Mo<sub>28</sub>O<sub>84</sub>(H<sub>2</sub>O)<sub>2</sub>]<sup>6-</sup> Anions (1999)

The five reduced polyoxomolybdate anions [HSiMo12O40]4- (HIβ), [H2SiMo12O40]4- (H2IIβ), [H5SiMo12O40]3- (H5IVβ), [SiMo14O44]4- (SiMo14), and [Si2Mo28O84(H2O)2]6- (Si2Mo28) have been synthesized as tetramethylammonium salts, by hydrothermal reactions, and characterized by IR spectroscopy, redox titrations (HIβ, H2IIβ), and X-ray crystal structure analyses. Crystal data: (TMA)4HIβ·1.5H2O, monoclinic space group P21/n, a = 12.2487(3) Å, b = 39.9307(11) Å, c = 12.4761(3) Å, β = 116.542(1)°; (TMA)4H2IIβ·2H2O, monoclinic space group P21/n, a = 12.7930(2) Å, b = 21.6171(2) Å, c = 19.7222(2) Å, β = 96.017(1)°; (TMA)3H5IVβ·2H2O, monoclinic space group P21/n, a = 12.7763(5) Å, b = 20.2277(8) Å, c = 20.9784(9) Å, β = 98.037(1)°; (TMA)4SiMo14, monoclinic space group P21/n, a = 12.0502(4) Å, b = 11.7500(4) Å, c = 19.8001(5) Å, β = 100.525(1)°; (TMA)6Si2Mo28·2H2O, monoclinic space group P21/n, a = 19.3591(2) Å, b = 13.1119(2) Å, c = 21.1265(2) Å, β = 101.124(1)°. HIβ, H2IIβ, and H5IVβ are respectively one-, two-, and four-electron-reduced {SiMo12O40} anions with the β-Keggin type structure. SiMo14 and Si2Mo28 are two novel anions containing α-Keggin cores; in SiMo14 the Keggin core is capped by two {MoO2} units while in Si2Mo28 two bicapped anions are linked through terminal oxo groups. A comparison of the molecular structures of the five anions shows the role of the protonation, the reduction, and the aggregation of capping {MoO2} units on the structural features of the Keggin core. The condensation process is discussed in terms of Lewis-type interactions between reduced, highly charged basic polyanions and reactive {MoO2}2+ units.
Dynamics of Wide Bandwidth Semiconductor Lasers (1997)

In this paper we summarize the most important recent advances and results in high speed diode lasers. These advances have primarily come about as a result of physical understanding of the properties that affect the dynamic performance of these lasers. A great deal of progress has been made in understanding the active region properties of such devices, including the electron and hole transport dynamics as well as the effect of active region doping and strain. At the very high frequencies characteristic of the highest speed lasers reported to date the microwave signal propagation becomes an important issue that can limit the laser bandwidth. The distribution of signals along the laser length due to these effects are discussed, analyzed, and measured, and conclusions about bandwidth and device operation are drawn from the analysis. All of these different issues are summarized in this paper from both a theoretical and experimental perspective. The laser structures that address and overcome the problems caused by such factors are presented along with the best results obtained to date.
Faculty Opinions recommendation of Targeting RNA: A transformative therapeutic strategy. (2019)

The therapeutic pathways that modulate transcription mechanisms currently include gene knockdown and splicing modulation.However, additional mechanisms may come into play as more understanding of molecular biology and disease etiology emerge.Building on advances in chemistry and delivery technology, oligonucleotide therapeutics is emerging as an established, validated class of drugs that can modulate a multitude of genetic targets.These targets include over 10,000 proteins in the human genome that have hitherto been considered undruggable by small molecules and protein therapeutics.The approval of five oligonucleotides within the last 2 years elicited unprecedented excitement in the field.However, there are remaining challenges to overcome and significant room for future innovation to fully realize the potential of oligonucleotide therapeutics.In this review, we focus on the translational strategies encompassing preclinical evaluation and clinical development in the context of approved oligonucleotide therapeutics.Translational approaches with respect to pharmacology, pharmacokinetics, cardiac safety evaluation, and dose selection that are specific to this class of drugs are reviewed with examples.The mechanism of action, chemical evolution, and intracellular delivery of oligonucleotide therapies are only briefly reviewed to provide a general background for this class of drugs.
Screen-printed Flexible and Transparent Antenna (2019)

Optically transparent antennas have attracted considerable attention in the past few decades due to potential applications in solar panels and wireless communications. However, the designs are typically based on transparent conductive oxides, which suffer from low transparency, high cost and poor flexibility. In this paper, an optically transparent, mechanically flexible monopole antenna is presented, which has been realized through screen-printing of silver nanowires (Ag NWs) in high efficiency. The proposed monopole antenna has been printed on a 50-μm-thick polyethylene terephthalate substrate. The total size of the antenna is 12×12 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and the operating frequency covers Ku- and Ka-band (18-40 GHz), which makes the antenna suitable for mm-wave applications including 5G communication. The antenna demonstrates excellent stability over 100 bending cycles with a radius of 4 mm. More importantly, 89% transmittance has been achieved at a wavelength of 550 nm, which is better than transparent antennas in literature.
Tgf-βL, 2 & 3 in the Eye Stimulate Ocular Scarring but Cellular Effects Depend on Extracellular Environment (1998)

Conference Abstract| August 01 1998 Tgf-βL, 2 & 3 in the Eye Stimulate Ocular Scarring but Cellular Effects Depend on Extracellular Environment MF Cordeiro; MF Cordeiro 1Wound Healing Research and Glaucoma Units, Institute of Ophthalmology and Moorfields Eye Hospital, London EC1V 9EL, England Search for other works by this author on: This Site PubMed Google Scholar SS Bhattacharya; SS Bhattacharya 2Wound Healing Research and Glaucoma Units, Institute of Ophthalmology and Moorfields Eye Hospital, London EC1V 9EL, England Search for other works by this author on: This Site PubMed Google Scholar PT Khaw PT Khaw 3Wound Healing Research and Glaucoma Units, Institute of Ophthalmology and Moorfields Eye Hospital, London EC1V 9EL, England Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1998) 95 (s39): 14P. https://doi.org/10.1042/cs095014p Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation MF Cordeiro, SS Bhattacharya, PT Khaw; Tgf-βL, 2 & 3 in the Eye Stimulate Ocular Scarring but Cellular Effects Depend on Extracellular Environment. Clin Sci (Lond) 1 August 1998; 95 (s39): 14P. doi: https://doi.org/10.1042/cs095014p Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1988 The Biochemical Society and the Medical Research Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
Field evaluation of 3‐hydroxy‐2‐hexanone and ethanol as attractants for the cerambycid beetle pest of vineyards, <i>Xylotrechus arvicola</i> (2016)

Attraction of females for the male-produced compound (R)-3-hydroxy-2-hexanone has been observed in laboratory but not in field experiments. Traps baited with ethanol are highly attractive to both sexes of adults of X. arvicola, and these can be used for improved monitoring of the adult emergence and for population control by mass trapping. © 2016 Society of Chemical Industry.
Potential synthetic lubricants: Diol ester of C<sub>18</sub>‐saturated cyclic acids (1967)

Abstract Monoalkyl esters of linseed‐oil‐derived C 18 ‐saturated cyclic acids (HCal), described in earlier work, showed promise as lubricant base stocks for turbine aircraft as set forth in the military specification MIL‐L‐7808E. These esters, however, did not exhibit the increased oxidative stability and higher viscosity required by the more recent specification MIL‐L‐23699. Six diol esters of HCal have now been prepared. Both hindered and unhindered dihydric alcohols were used, including ethylene glycol, 1,4‐cyclohexanedimethanol, 1,4‐benzenedimethanol, 2,3‐dimethyl‐1,3‐propanediol and 2,2,4,4‐tetramethyl‐1,3‐cyclobutanediol (I). The viscosities of these esters at 210F ranged from 10.1 to 19.6 centistokes and the pour points, from ‐35 to ‐62F. Oxidative stabilities at 400F were determined with 0.5% each of phenyl‐ a ‐napthylamine (PANA) and p,p' ‐dioctyldiphenylamine as inhibitors. The esters of the unhindered diols had poor stability, whereas esters of the hindered diols, in particular I, exhibited excellent resistance to the formation of acidic decomposition products and sludge. Although the HCal ester of I by itself is too viscous to meet specification MIL‐L‐23699, its ASTM slope (0.650) is excellent. Blends of this material with less viscous hindered esters, commercially available, may find application as lubricants for high‐performance turbine engines used in various aircraft.
Paraxial determination of the general four-component zoom system with mechanical compensation (1995)

To determine paraxial properties of the general four-component zoom system with mechanical compensation we must have the methods to obtain the optical power distribution and test and evaluate kinematics. There are two important approaches to general conception of a four- component zoom system. The first refers to the expansion of the method for three types of zoom systems. According to the location of an object and image in relation to a zoom system, we distinguish the following zoom systems: variable focal lenses, projection or reproduction systems, and afocal attachments. The second refers to the expansion of kinematic possibilities of all zoom components and even an object plane. Research led to the conclusion that knowing the marginal positions and extreme values of the main useful parameters connected with them is quite sufficient to obtain the optical power distribution of the individual components. Changing the input data we may minimize the longitudinal dimension of the zoom system. Sort of a zoom system is determined by paraxial aperture coordinates at the edges of a zoom system. The first optical power is calculated from the equation being four degrees of polynomial. We have four solutions of this equation and have four propositions of the optical power distributions in a four-component zoom system. All remaining optical powers in the four-component zoom system are expressed by the first optical power. Calculation of optical powers in this way means that the zoom system is good only in both marginal positions. Research led to the statement that, optical conjugate and fixed image location are determined from a quadratic equation. To verify kinematics of the zoom system it is necessary to determine the variation of the main useful parameter and, if required, variation of movements of the first and fourth component. After kinematic calculations we should first test whether the travel from start to the final position is smooth. Later we evaluate kinematics and, if possible, correct it by mentioned changes or even by modification of marginal positions.
Local search algorithms for geometric object recognition: optimal correspondence and pose (1993)

Recognizing an object by its shape is a fundamental problem in computer vision, and typically involves finding a discrete correspondence between object model and image features as well as the pose--position and orientation--of the camera relative to the object. This thesis presents new algorithms for finding the optimal correspondence and pose of a rigid 3D object. They utilize new techniques for evaluating geometric matches and for searching the combinatorial space of possible matches. An efficient closed-form technique for computing pose under weak-perspective (four parameter 2D affine) is presented, and an iterative non-linear 3D pose algorithm is used to support matching under full 3D perspective. A match error ranks matches by summing a fit error, which measures the quality of the spatial fit between corresponding line segments forming an object model and line segments extracted from an image, and an omission error, which penalizes matches which leave portions of the model omitted or unmatched. Inclusion of omission is crucial to success when matching to corrupted and partial image data. New optimal matching algorithms use a form of combinatorial optimization called local search, which relies on iterative improvement and random sampling to probabilistically find globally optimal matches. A novel variant has been developed, subset-convergent local search finds optimal matches with high probability on problems known to be difficult for other techniques. Specifically, it does well on a test suite of highly fragmented and cluttered data, symmetric object models, and multiple model instances. Problem search spaces grows exponentially in the number of potentially paired features n, yet empirical performance suggests computation is bounded by $n\\sp2.$ Using the 3D pose algorithm during matching, local search solves problems involving significant amounts of 3D perspective. No previous work on geometric matching has generalized in this way. Our hybrid algorithm combines the closed-form weak-perspective pose and iterative 3D pose algorithms to efficiently solve matching problems involving perspective. For robot navigation, this algorithm recognizes 3D landmarks, and thereby permits a mobile robot to successfully update its estimated pose relative to these landmarks.
Efficient Construction of Simultaneous Deterministic Finite Automata on Multicores Using Rabin Fingerprints (2015)

In this paper, we propose several optimizations for the SFA construction algorithm, which greatly reduce the in-memory footprint and the processing steps required to construct an SFA. We introduce fingerprints as a space- and time-efficient way to represent SFA states. To compute fingerprints, we apply the Barrett reduction algorithm and accelerate it using recent additions to the x86 instruction set architecture. We exploit fingerprints to introduce hashing for further optimizations. Our parallel SFA construction algorithm is nonblocking and utilizes instruction-level, data-level, and task-level parallelism of coarse-, medium- and fine-grained granularity. We adapt static workload distributions and align the SFA data-structures with the constraints of multicore memory hierarchies, to increase the locality of memory accesses and facilitate HW prefetching. We conduct experiments on the PROSITE protein database for FAs of up to 702 FA states to evaluate performance and effectiveness of our proposed optimizations. Evaluations have been conducted on a 4 CPU (64 cores) AMD Opteron 6378 system and a 2 CPU (28 cores, 2 hyperthreads per core) Intel Xeon E5-2697 v3 system. The observed speedups over the sequential baseline algorithm are up to 118541x on the AMD system and 2113968x on the Intel system.