gebhart/patrepeval huggingface dataset:
PMD-Insensitive OSNR Monitoring Based on Polarization-Nulling With Off-Center Narrow-Band Filtering (2004)

We propose and experimentally demonstrate the use of polarization-nulling with off-center narrow-band filtering to realize a new polarization-mode dispersion (PMD)-insensitive in-band optical signal-to-noise ratio monitoring scheme. When applied to a 39.81-Gb/s 2.5-ps full-width at half-maximum return-to-zero on-off keyed optical time-division-multiplexing system with 10and 20-ps differential group delay, the monitoring errors were reduced from >20 dB to <0.9 and <1.6 dB, respectively, hence demonstrating the feasibility of this scheme even under severe PMD degradation. This technique is simple and can be easily upgraded for use in higher data-rate optical systems.
Design pattern integrated tool (2004)

The use of design patterns in the mainstream has been limited due technical restrictions in supporting tools. We developed an integrated tool that supports language and platform independence, and facilitates cross-platform interoperability. The tool also assists in coding and design validating for quality assurance.
Robotic forklifts for intelligent warehouses: Routing, path planning, and auto-localization (2010)

Today, robotic systems are bridging the gaps between global economy, social needs, and logistics focusing on sustainable development solutions. Everyday new robotic applications can be found in literature and media. Some of them are basically entertainment toys. Nevertheless, the great majority of them is used inside industries, performing several tasks (painting, welding, moving materials, etc.). In a scenario of global economy growth, any sustainable solution that can reduce the product final cost is welcome. This article presents researches on robotic forklifts for intelligent warehouses developed at the Mechatronics Lab at USP-EESC in Brazil. We show three key-routines that determine the Automated Guided Vehicle (AGV) behavior: the routing algorithm (that computes the overall task execution time and the minimum global path of each AGV using a topological map of the warehouse), the local path planning algorithm (based on A* it searches for the local minimum path between two nodes of the warehouse topological map), and an auto-localization algorithm (that applies an Extended Kalman Filter - EKF - to estimate the AGVs actual positions). In order to validate the algorithms developed, several tests were carried out using the simulation software Player/Stage. The results obtained were encouraging and the router developed was able to solve traffic jams and collisions, before sending the final paths to the robots. In a near future all algorithms will be implemented using mini- robotic forklifts and a scaled environment built in our lab.
COS/MOS phase comparator (1973)

COS/MOS MSI technology has been applied to the integration of a high performance phase comparator for use in a UHF frequency synthesizer capable of selecting any of 7000 channels with a 25-kHz spacing in the 225-400 MHz frequency range.
Effect of additives on the stability of mango aroma concentrate during storage. (1997)

The storage behaviour of aroma concentrates form 'Alphonso' mangoes was studied at room tempeture (26-28
Jonathan Edwards. Treatise on Grace and Other Posthumously Published Writings, ed. Paul Helm. Pp. x + 131. (Cambridge and London: James Clarke, 1971). £1·50. (1973)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Arctigenin Protects Focal Cerebral Ischemia-Reperfusion Rats through Inhibiting Neuroinflammation (2012)

Stroke is the third leading cause of death in industrialized countries and the most important cause of acquired adult disability. Many evidences suggest that inflammation accounts for the progression of cerebral ischemic injury. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignin isolated from certain plants, has shown anti-inflammatory activity against diabetes and Alzheimer's disease. In this study, we tested whether arctigenin can protect middle cerebral artery occluded (MCAO) rats. Male Sprague-Dawley rats were pretreated with arctigenin or vehicle for 7 d before being subjected to transient occlusion of middle cerebral artery and reperfusion. Rats were evaluated at 24 h after MCAO for neurological deficit scoring. Furthermore, the mechanism of the anti-inflammatory effect of arctigenin was investigated with a focus on inflammatory cells, proinflammatory cytokines, and transcriptional factors. Arctigenin significantly reduced cerebral infarction and improved neurological outcome. Arctigenin suppressed the activation of microglia and decreased the expression of interleukin (IL)- 1β and tumor necrosis factor (TNF)-α. These results revealed that arctigenin has a promising therapeutic effect in ischemic stroke treatment through an anti-inflammatory mechanism.
Synthesis and characterization of amorphous carbon nanowires (1999)

By heating a pressed tablet of graphite powder mixed with nickel in a quartz tube mounted inside a high-temperature tube furnace at 1200 °C, amorphous carbon nanowires were formed on the inner wall of the quartz tube near a copper cooling finger. Bright-field images of transmission electron microscopy show that the diameters of the nanowires are around 40 nm. Selected-area electron diffraction and Raman study reveal that the nanowires have an amorphous structure.
Successful ustekinumab treatment of noninfectious uveitis and concomitant severe psoriatic arthritis and plaque psoriasis (2017)

We report the first successful treatment of noninfectious uveitis with ustekinumab in a patient with severe concomitant psoriasis and psoriatic arthritis who failed to respond to conventional immune suppressants and with contraindications to tumor necrosis factor alpha inhibitors.
Inverse Bestrahlungsplanung für intensitätsmodulierte Strahlenfelder mit Linearer Programmierung als Optimierungsmethode (2003)

Bei der Strahlentherapie werden Tumorpatienten mit Hilfe einer externen Strahlenquelle gezielt bestrahlt. In den letzten Jahren ist verstarkt die Verwendung von intensitatsmodulierten Strahlenfeldern zur besonderen Schonung von Risikoorganen untersucht worden. Dabei werden im Gegensatz zu offenen Strahlenfeldern die Strahlen in Teilstrahlen unterteilt, denen unterschiedliche Intensitaten zugewiesen werden konnen. Vor jeder Strahlenbehandlung ist dabei eine sorgfaltige Bestrahlungsplanung erforderlich. Die im Rahmen der Arbeit entwickelten Konzepte verwenden die Lineare Programmierung als Optimierungsmethode zur Bestrahlungsplanung fur intensitatsmodulierte Strahlenfelder. Die Vollstandigkeitseigenschaft dieses Verfahrens garantiert, dass die berechneten Behandlungsplane die vom Arzt geforderten Dosisschranken einhalten. Die dabei moglicherweise auftretende Unlosbarkeit bei physikalisch nicht realisierbarer Dosisverteilung kann durch die neuen Ansatze erfolgreich aufgelost werden. Durch diese Ansatze und die Verwendung effizienter Algoritmen fur die Lineare Programmierung konnen im Vergleich zu anderen Optimierungsverfahren qualitativ hervorragende Behandlungsplane in kurzen Planungszeiten erzielt werden. Die Implementierung der neuen Konzepte ergibt ein sehr flexibles Bestrahlungsplanungssystem, das gut in das klinische Umfeld integriert worden ist. Erfolgreiche Patientenbehandlungen konnten abschliesend die Leistungsfahigkeit der entwickelten Verfahren und Ansatze demonstrieren.
Cross-Sectional Analysis of Data from the U.S. Clinical Trials Database Reveals Poor Translational Clinical Trial Effort for Traumatic Brain Injury, Compared with Stroke (2014)

Traumatic brain injury (TBI) is an important public health problem, comparable to stroke in incidence and prevalence. Few interventions have proven efficacy in TBI, and clinical trials are, therefore, necessary to advance management in TBI. We describe the current clinical trial landscape in traumatic brain injury and compare it with the trial efforts for stroke. For this, we analysed all stroke and TBI studies registered on the US Clinical Trials (www.clinicaltrials.gov) database over a 10-year period (01/01/2000 to 01/31/2013). This methodology has been previously used to analyse clinical trial efforts in other specialties. We describe the research profile in each area: total number of studies, total number of participants and change in number of research studies over time. We also analysed key study characteristics, such as enrolment number and scope of recruitment. We found a mismatch between relative public health burden and relative research effort in each disease. Despite TBI having comparable prevalence and higher incidence than stroke, it has around one fifth of the number of clinical trials and participant recruitment. Both stroke and TBI have experienced an increase in the number of studies over the examined time period, but the rate of growth for TBI is one third that for stroke. Small-scale (<1000 participants per trial) and single centre studies form the majority of clinical trials in both stroke and TBI, with TBI having significantly fewer studies with international recruitment. We discuss the consequences of these findings and how the situation might be improved. A sustained research effort, entailing increased international collaboration and rethinking the methodology of running clinical trials, is required in order to improve outcomes after traumatic brain injury.
Impact of CD3/T Regs Ratio in Donor Graft On Survival Rates in Allogeneic Peripheral Blood Stem Cell Transplantation (2012)

Abstract Abstract 2030 Background: The therapeutic efficacy of allogeneic stem cell transplantation (alloSCT) for hematological malignancies relies largely on the graft versus leukemia (GvL) effect exerted by the donor CD3 cells, but an uncontrolled graft-versus-host-disease (GvHD) bears a risk of complications. On the other hand, T regs cells (CD4+CD25high Foxp3+) are believed to maintain tolerance and to inhibit GvHD after alloSCT; also, the Foxp3 gene encodes a transcription factor that is a key for thymic development, so T regs cells could preserve an optimal microenviroment for the reconstitution of functional immunity after alloSCT. Moreover, when looking at post allotransplant patients' outcomes, while it is largely known the impact of acute GVHD (triggered by CD3 donor T cells) on survival, there is no evidence that donor graft CD3/T regs ratio may determine an effect in terms of OS, NRM and relapse free survival rates so far. Patients and Methods: In this study we analyzed the graft CD3+/Tregs ratio (gCD3/Tregs R) and determined its impact on acute GVHD (aGVHD), immunological recovery and survival rates (OS, NRM and Relapse) after myeloablative alloPBSCT. We analyzed 74 consecutive patients transplanted with unmanipulated peripheral blood stem cells from an HLA identical related donor (n=48) or an HLA identical unrelated donor (n=26); diagnoses were acute myeloid leukaemia (n=62), acute lymphoblastic leukaemia (n=13). The median CD3+ and Tregs dose administered was 238 (range (r): 67–550) and 12,5×106̂/Kg (r: 2–21), respectively; the median gCD3/Tregs R was 19 (r: 8–250). Patients were subdivided into a high gCD3/Tregs R (>=36) group (HR group n= 30) and a low gCD3/Tregs R (<36) (LR group n=44). Results: The incidence of aGVHD (grade II-IV) in the low gCD3/Tregs R (LR) group was lower than in the high gCD3/Tregs R (HR) group (4/30 or 13% vs 36/44 or 82%, p<.001). The OS, NRM and relapse rate at 3 years was 54,29 and 34%, respectively. Comparing LR with HR group a statistically significant difference is demonstrated for OS and NRM rates (65 vs 31%,p<.004; 3 vs 71%, p<.001), respectively, but not for the R one (35 vs 30%, p=ns). Comparing aGVHD+ with aGVHD- group OS, NRM and relapse were always statistically significant different (39 vs 65%,p<.005; 61 vs 7%,p<.001; 9 vs 53%,p<.002). Conclusions: Taken together, our data may suggest that Tregs content is able to mediate protective effects against aGVHD, while preserving GvL effects as demonstrated by relapse rate comparison between H and LR groups. However, larger studies are needed to understand the real contribution of gCD3/Tregs R on survival rates. Disclosures: No relevant conflicts of interest to declare.
Analysis of correlation between thyroid hormone and hepatic enzymes in type 2 diabetic patients (2011)

Objective: To investigate the correlation between thyroid hormone and hepatic enzymes in type 2 diabetic patients.Methods: 522 patients with 2-type diabetes were enrolled.The serum concentrations of TT3,TT4,FT3,FT4,TSH,ALT,AST,ALP and GGT were measured.And the experimental groups were classified by the serum levels of FT3,FT4 and TSH.Then the relationship between thyroid hormone and enzymes were assessed.Results: The serum concentrations of ALT,ALP and GGT in group 1 and group 5,and ALP in group 2 were higher than those in control group(P0.05).After controlling for serum glucose,the partial correlation analysis showed that TT3 was related to ALT and GGT,TT4 was related to ALT,FT3 was related to ALT and GGT(P0.01);None enzymes was related to FT4 and TSH.Conclusion: The correlation between thyroid hormone and enzymes in type 2 diabetic patients is significant.And it is assumed that thyroid hormone might be a protective factor for hepatic damage in type 2 diabetes.
Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing (2011)

When administered either systemically or centrally, glucose is a potent enhancer of memory processes. Measures of glucose levels in extracellular fluid in the rat hippocampus during memory tests reveal that these levels are dynamic, decreasing in response to memory tasks and loads; exogenous glucose blocks these decreases and enhances memory. The present experiments test the hypothesis that glucose enhancement of memory is mediated by glycogen storage and then metabolism to lactate in astrocytes, which provide lactate to neurons as an energy substrate. Sensitive bioprobes were used to measure brain glucose and lactate levels in 1-sec samples. Extracellular glucose decreased and lactate increased while rats performed a spatial working memory task. Intrahippocampal infusions of lactate enhanced memory in this task. In addition, pharmacological inhibition of astrocytic glycogenolysis impaired memory and this impairment was reversed by administration of lactate or glucose, both of which can provide lactate to neurons in the absence of glycogenolysis. Pharmacological block of the monocarboxylate transporter responsible for lactate uptake into neurons also impaired memory and this impairment was not reversed by either glucose or lactate. These findings support the view that astrocytes regulate memory formation by controlling the provision of lactate to support neuronal functions.
Modified CMA based blind equalization and carrier-phase recovery in PDM-QPSK coherent optical receivers (2014)

Digital coherent optical receivers enable equalization of fiber transmission impairments and carrier-phase estimation in digital domain. In this paper, a novel equalization and carrier-phase recovery algorithm, both based on modified constant-modulus algorithm (CMA), is proposed for polarization-division multiplexed quadrature phase-shift keying (PDM-QPSK) systems. The proposed scheme is validated with 40-Gbits/s PDM-QPSK transmission experiments.
Fiber supercontinuum sources (Invited) (2007)

We review supercontinuum generation in optical fibers for particular cases where the nonlinear spectral broadening is induced by pump radiation from fiber-format sources. Based on numerical simulations, our paper is intended to provide experimental design guidelines tailored ytterbium and erbium-based pumps around 1060 and 1550 nm, respectively. In particular, at 1060 nm, we consider conditions under which the generated spectra are phase and intensity stable, and we address the dependence of the supercontinuum coherence on the input pulse parameters and the fiber length. At 1550 nm, special attention is paid to the case of dispersion-flattened dispersion-decreasing fiber, where we revisit the underlying physics in detail and explicitly examine the use of such fiber for supercontinuum generation with pumps of peak power in the range 200-1200 W and sub-10 m fiber lengths. We show that supercontinuum generation under such conditions can be highly coherent and can be applied to nonlinear pulse compression.
Spatial resolution requirements for digital chest radiographs: an ROC study of observer performance in selected cases. (1986)

Thirty-eight selected clinical radiographs were digitized and displayed on a 1,024-line monitor at pixel sizes of 1.6, 0.8, 0.4, and 0.2 mm. Eighteen experienced radiologists assessed the radiographs and digital images, which included 12 examples of abnormal solitary nodular density, ten examples of septal lines, and 16 controls, six of which showed diffuse lung abnormalities. For each level of spatial resolution and for film reading, observers gave their decision confidence on a sliding scale of probability. Receiver operating characteristic curves were generated from these data. It was found that while spatial resolution requirements for solitary nodules were not critical for pixel sizes at or below 0.8 mm, the requirement for septal lines was likely to be 0.4 mm (1.25 line pairs/mm).
CMOS subnanosecond true-ECL output buffer (1989)

This paper presents, for the first time, a CMOS output buffer circuit compatible with standard ECL lOOk systems and not needing external components or additional supply voltages. High speed (0.9 ns delay), sufficient precision and good pulse-response are achieved through use of a new circuit principle. The circuit has been fabricated in an 0.7 μm memory process.
Utility-Based Video Adaptation for Universal Multimedia Access (UMA) and Content-Based Utility Function Prediction for Real-Time Video Transcoding (2007)

Many techniques exist for adapting videos to satisfy heterogeneous resource conditions or user preferences, whereas selection of the best adaptation operation among various choices usually is either ad hoc or inefficient. To provide a systematic solution, we present a conceptual framework based on utility function (UF), which models video entity, adaptation, resource, utility, and the relations among them. In order to support real-time video adaptation, we present a content-based statistical paradigm to facilitate the prediction of UF for real-time transcoding of live videos. Instead of modelling the UF through analytical models, as in the conventional rate-distortion framework, the proposed approach formulates the prediction as a classification and regression problem. Each video clip is classified into one of distinctive categories and then local regression is used to accurately predict the utility value. Our extensive experiment results based on MPEG-4 transcoding demonstrate that the proposed method achieves very promising performance - up to 89% accuracy in choosing the optimal transcoding operation (in both spatial and temporal dimensions) with the highest quality over a diverse range of target bit rates
DNA damage induced by shikonin in the presence of Cu(II) ions: potential mechanism of its activity to apoptotic cell death (2011)

Shikonin (β-alkannin), a naphthazarin derivative, has shown a variety of abilities such as anti-inflammatory, antitumoral, cytotoxic, and antimicrobial activities. In the presence of Cu(II), shikonin caused breakage of supercoiled plasmid pBR322 DNA. Other metal ions tested [Mg(II), Ca(II), and Ni(II)] were ineffective and only Fe(II) has the same ability in the DNA breakage reaction. The involvement of active oxygen in the reaction was established by the inhibition of DNA breakage by superoxide dismutase, catalase, thiourea, sodium azide, potassium iodide, and sodium benzoate. Cu(I) was shown to be an essential intermediate using the Cu(I)-specific sequestering reagent neocuproine. Shikonin induced HeLa cell apoptosis involved in the mechanism of increasing intracellular reactive oxygen species (ROS). It was suggested that shikonin generated ROS as a pro-oxidant in the presence of Cu(II), and ROS resulted in DNA damage and apoptotic cell death in cells.
Supported Nitric Acid on Silica Gel and Polyvinyl Pyrrolidone (PVP) as an Efficient Oxidizing Agent for the Oxidation of Urazoles and Bis-urazoles (2009)

Abstract A method for the oxidation of a good range of urazoles and bis-urazoles to the corresponding triazolinediones by supported nitric acid on silica gel (SiO2-HNO3) and/or polyvinyl pyrrolidone (PVP-HNO3) is described. Reactions have been carried out heterogeneously at room temperature in dichloromethane with good to excellent yields.
Application of statistical process control charts to monitor changes in animal production systems1 (2010)

Statistical process control (SPC) is a method of monitoring, controlling, and improving a process through statistical analysis. An important SPC tool is the control chart, which can be used to detect changes in production processes, including animal production systems, with a statistical level of confidence. This paper introduces the philosophy and types of control charts, design and performance issues, and provides a review of control chart applications in animal production systems found in the literature from 1977 to 2009. Primarily Shewhart and cumulative sum control charts have been described in animal production systems, with examples found in poultry, swine, dairy, and beef production systems. Examples include monitoring of growth, disease incidence, water intake, milk production, and reproductive performance. Most applications describe charting outcome variables, but more examples of control charts applied to input variables are needed, such as compliance to protocols, feeding practice, diet composition, and environmental factors. Common challenges for applications in animal production systems are the identification of the best statistical model for the common cause variability, grouping of data, selection of type of control chart, the cost of false alarms and lack of signals, and difficulty identifying the special causes when a change is signaled. Nevertheless, carefully constructed control charts are powerful methods to monitor animal production systems. Control charts might also supplement randomized controlled trials.
The Image Engine HPCC project. A medical digital library system using agent-based technology to create an integrated view of the electronic medical record (2002)

This paper describes the Image Engine project supported by the National Library of Medicine's (NLM) biomedical applications of High Performance Computing and Communications (BAA/HPCC) program. Image Engine is a multi-user, object-oriented, client server database system for the storage, retrieval, integration and sharing of a wide range of biomedical images. In addition, Image Engine uses agent-based technology to implement real-time links between medical images and associated data stored in external database systems. This project is a first step towards implementing a multimedia electronic medical record system. As a digital library architecture Image Engine has the potential to support innovative applications in the clinical, research and educational domains of medicine.
Spectrometers for Radiation Protection at Chalk River Nuclear Laboratories (1985)

Journal Article Spectrometers for Radiation Protection at Chalk River Nuclear Laboratories Get access H. Ing, H. Ing Search for other works by this author on: Oxford Academic PubMed Google Scholar W.G. Cross, W.G. Cross Search for other works by this author on: Oxford Academic PubMed Google Scholar P.J. Bunge P.J. Bunge Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 10, Issue 1-4, 1 January 1985, Pages 137–145, https://doi.org/10.1093/oxfordjournals.rpd.a079418 Published: 01 January 1985