gebhart/patrepeval huggingface dataset:
Trailer parking assistant (2014)

This paper presents a method which would enable the car with coupled trailer to backup safely, preventing i.e. from jack-knifing and provide the driver assistance with steering the trailer in a desired direction. Presented method is based on developing new algorithms for the current parking assistant electronic control units (ECUs) using the ultrasonic sensors. Key idea is to estimate the length of the trailer shaft (axle to coupling length), and the angle between the car and trailer. With those the control for the steering of the car to backup the trailer in the desired direction can be designed.
Autotaxin/lysophosphatidic acid signaling mediates obesity‐related cardiomyopathy in mice and human subjects (2018)

Obesity is associated with increased cardiovascular morbidity and mortality, but the direct signals to initiate or exaggerate cardiomyopathy remain largely unknown. Present study aims to explore the pathophysiological role of autotaxin/lysophosphatidic acid (LPA) in the process of cardiomyopathy during obesity. Through utilizing mouse model and clinical samples, present study investigates the therapeutic benefits of autotaxin inhibitor and clinical correlation to obesity-related cardiomyopathy. The elevated circulating levels of autotaxin are closely associated with cardiac parameters in mice. Administration with autotaxin inhibitor, PF-8380 effectively attenuates high fat diet-induced cardiac hypertrophy, dysfunction and inflammatory response. Consistently, autotaxin inhibition also decreases circulating LPA levels in obese mice. In in vitro study, LPA directly initiates cell size enlargement and inflammation in neonatal cardiomyocytes. More importantly, circulating levels of autotaxin are positively correlated with cardiac dysfunction and hypertrophy in 55 patients. In conclusion, present study uncovers the correlation between circulating autotaxin and cardiac parameters in mice and human patient, and provided solid evidence of the therapeutic application of autotaxin inhibitor in combating obesity-related cardiomyopathy.
Synthesis of β-carbonylphosphine oxides and phenyl-substituted ethylenediphosphine oxides. study of their complexing with alkali metals cations (2009)

The synthesis of some β-carbonylphosphine oxides and phenyl-substituted ethylenediphosphine oxides was carried out. Their complexing with alkali metals cations was studied. Compounds obtained were shown to possess clearly expressed Li/Na selectivity.
Transvaginal Sonographic Characterization of Ovarian Disease: Evaluation of a New Scoring System to Predict Ovarian Malignancy (1992)

With the advent of high-frequency transvaginal ultrasonography, new opportunities are presented to better define ovarian lesions. The goal of this study was to develop a scoring system using transvaginal sonographic characterization of pelvic/ovarian lesions. Our purpose was to maximize the discrimination between benign and malignant entities. Transvaginal sonographic pelvic images of 143 patients were correlated with surgical findings or histopathology. Of 281 ovaries, 108 had benign lesions (30 endometriomas, 24 teratomas, 21 simple cysts, and 33 other abnormalities) and 20 had malignancies. The scoring system devised was useful in distinguishing benign from malignant masses, with a specificity of 83%, sensitivity of 100%, and positive and negative predictive values of 37 and 100%, respectively. Further experience and refinements of this method of scoring should maximize the benefit of high-resolution transvaginal sonography of ovarian lesions.
DNA of avian myeloblastosis-associated virus type 2 integrates at multiple sites in the chicken genome (1980)

The cellular sites of integration of the avian myeloblastosis-associated virus type 2 (MAV-2) DNA have been examined by Southern blot analysis of cellular DNA from infected cloned and uncloned chicken embryonic fibroblasts. Provirus-cell juncture fragments were not detected in restriction enzyme digests of DNA from MAV-2-infected uncloned cells. However, each MAV-2-infected cell clone examined produced a unique set of junctive bands. Thse findings indicate that multiple sites of integration exists for MAV-2 proviruses in cellular DNA.
Inhibition of Cortisol Secretion in Dispersed Head Kidney Cells of Rainbow Trout (Oncorhynchus mykiss) by Endosulfan, an Organochlorine Pesticide (2001)

The effects of endosulfan, an organochlorine pesticide, on cortisol secretion in vitro were investigated in enzymatically dispersed head kidney cells of rainbow trout, Oncorhynchus mykiss. First, the conditions for maximal cortisol secretion were characterized by selecting the optimal concentrations of adrenocorticotropin (ACTH) (1 IU/ml) and N(6), 2'-o-dibutyryladenosine 3':5'-cyclic monophosphate (dbcAMP) (2 mM), incubation temperature (15 degrees ) and time period (60 min for ACTH, 120 min for dbcAMP), number of cells per incubation well (75 x 10(6)/ml), and osmolarity of the medium (270 mosmol/L). Exposure of head kidney cells to endosulfan decreased ACTH- or dbcAMP-stimulated cortisol secretion and cell viability in a concentration-dependent pattern and the doses required to disrupt cortisol secretion were significantly lower than doses lethal to the head kidney cells. The median effective concentration of endosulfan (EC(50), the dose that inhibits cortisol secretion by 50%) was 17.3 microM while the median lethal concentration (LC(50), the dose that kills 50% of the cells) was 308 microM. Our study identified endosulfan as an environmental endocrine disrupting chemical that interferes with the normal secretory function of teleost interrenal steroidogenic cells. Multiple sites may be affected within the steroidogenic cells since dbcAMP could not restore cortisol secretion in endosulfan exposed cells.
Cooperative Overlay Spectrum Access in Cognitive Radio Networks (2017)

In order to mitigate the shortage of wireless spectrum, the appealing concepts of cooperative communication techniques and cognitive radio (CR) networks have been combined for the sake of improving the spectral efficiency and hence the overall system throughput. We mainly survey the overlay spectrum access scheme in this novel cooperative CR (CCR) network context. Therefore, the interference between the licensed users/primary users (PUs) and the unlicensed users/cognitive users (CUs) can be offset by relying on some of the CUs to act as relay nodes. More specifically, we have investigated the cooperative relaying technique in the context of the overlay spectrum access scheme aiming for allowing the PUs to transmit at a lower power and/or at a higher throughput, while at the same time enabling the CUs to communicate using the bandwidth released. Additionally, gaming techniques can be employed for negotiating between the PUs and the CUs for determining the specific fraction of relaying and active transmission time. Therefore, we will consider two main schemes in the overlay spectrum access scheme based on the CCR network, which are the frequency division-based channel as well as the time-division based channel. Moreover, we have surveyed the relevant advances concerning the game-based model of the overlay-based CR network. Specifically, both the family of non-cooperative and cooperative games as well as matching games have been reviewed. Furthermore, we will review the joint design of coding, modulation, user-cooperation, and CCR techniques, which leads to significant mutual benefits for both the PUs and CUs.
Celiac disease 2015 update: new therapies (2015)

Celiac disease (CD) is a chronic, small intestinal, immune-mediated enteropathy triggered by exposure to dietary gluten in genetically susceptible individuals. Currently, lifelong adherence to a gluten-free diet (GFD) is the only available treatment. However, GFD alone is not sufficient to relieve symptoms, control small intestinal inflammation and prevent long-term complications in many patients. The GFD has its challenges including issues related to adherence, lifestyle restrictions and cost. As a result, there is growing interest in and a need for non-dietary therapies to manage this condition. In recent years, different targets in the immune-mediated cascade of CD have been identified in clinical and pre-clinical trials for potential therapies. This review will discuss the latest non-dietary therapies in CD, including endopeptidases, modulators of enterocyte tight junctions and agents involved in gluten tolerization and immunomodulation. We will also discuss the potential implications of approved therapeutics on CD clinical practice.
Learning Natural Language Inference with LSTM (2016)

Natural language inference (NLI) is a fundamentally important task in natural language processing that has many applications. The recently released Stanford Natural Language Inference (SNLI) corpus has made it possible to develop and evaluate learning-centered methods such as deep neural networks for natural language inference (NLI). In this paper, we propose a special long short-term memory (LSTM) architecture for NLI. Our model builds on top of a recently proposed neural attention model for NLI but is based on a significantly different idea. Instead of deriving sentence embeddings for the premise and the hypothesis to be used for classification, our solution uses a match-LSTM to perform wordby-word matching of the hypothesis with the premise. This LSTM is able to place more emphasis on important word-level matching results. In particular, we observe that this LSTM remembers important mismatches that are critical for predicting the contradiction or the neutral relationship label. On the SNLI corpus, our model achieves an accuracy of 86.1%, outperforming the state of the art.
[Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty]. (1987)

Findings in several cases are used to demonstrate that certain vertebral angiomas may not be congenital and can ultimately provoke medullary or radicular neurologic complications. Radiotherapy is the usual treatment but is not always accepted unconditionally close to spinal cord. Destruction of angioma and consolidation of vertebral column can be obtained by percutaneous intrasomatic injection of acrylic cement. The preoperative radiologic examination includes direct phlebography with insertion of trocar, the vertebroplasty being performed under television screen surveillance. Results in seven patients treated are very encouraging but the current 2-year follow up requires extension. However, the method appears to be able to be included amongst treatment for an affection of sometimes seriously questioned benign nature.
Human infection with<i>Streptococcus zooepidemicus</i>(Lancefield group C): three case reports (1987)

Three unrelated severe infections with Streptococcus zooepidemicus occurred in England in 1985. The first patient developed septic arthritis, which has not been recorded before with this organism. The second died with septicaemia, pneumonia and post-streptococcal glomerulonephritis, the only record so far of nephritis following sporadic S. zooepidemicus infection and of nephritis and systemic sepsis in the same patient. The third patient experienced septicaemia during pregnancy but recovered without complications. A likely animal source of infection was found in only one case.
Variable Directional Coupler Employing Microfluidics (2008)

This paper details a novel variable directional coupler based on a broadside coupled stripline structure employing microfluidics. The coupler has shown good bandwidth of 7.5-12.5 GHz with only a single quarter wavelength section. The variable coupling has been achieved by creating chambers in the dielectric material between the two coupled strips. The chambers have the same length and width as the coupled strips. Conductive fluid is pumped in and out of each chamber leading to a change in coupling between the broadside coupled strips. Conductive fluids like the solution of ammonium chloride or potassium chloride have been used to change the conductivity of the chamber which provides the coupling variation. The chambers are isolated from each other by thin membranes. The fabrication is compatible with MIC techniques. A coupling variation of 24 dB to 11 dB has been obtained. The return loss characteristics at all ports are better than 15 dB.
Restriction endonucleases for pulsed field mapping of bacterial genomes (1987)

Fundamental to many bacterial genome mapping strategies currently under development is the need to cleave the genome into a few large DNA fragments that can be resolved by pulsed field gel electrophoresis. Identification of endonucleases that infrequently cut a genome is of key importance in this process. We show that the tetranucleotide CTAG is extremely rare in most bacterial genomes with G+C contents above 45%. As a consequence, most of the sixteen bacterial genomes we have tested are cleaved less than once every 100,000 base pairs by one or more endonucleases that have CTAG in their recognition sequences: Xba I (TCTAGA), Spe I (ACTAGT), Avr II (CCTAGG) and Nhe I (GCTAGC). Similarly, CCG and CGG are the rarest trinucleotides in many genomes with G+C content of less than 45%. Thus, Sma I (CCCGGG), Rsr II (CGGWCCG), Nae I (GCCGGC) and Sac II (CCGCGG) are often suitable endonucleases for producing fragments that average over 100,000 base pairs from such genomes. Pulsed field gel electrophoresis of the fragments that result from cleavage with endonucleases that cleave only a few times per genome should assist in the physical mapping of many prokaryotic genomes.
The Influence of Atmosphere on Oxides Crystal Growth (2012)

Oxide single crystals are known for wide application in electronics and optical industries, e.g. lasers, substrates, scintillators, nonlinear and passive optical devices (Brandle, 2004). The Czochralski technique has become an important method of choice for the growth and production of many bulk oxide materials owing to the possibility of growing crystals with large size, core free with good optical quality, and a high concentration of dopant, e.g., Nd3+, Yb+3 with better homogeneity (Zhaobing et al., 2007; Albrecht et al., 1998). Numerous researchers (Dupret and Bogaert, 1994; Cockayne et al., 1976; Valentino and Brandle, 1974; Brandle, and Barns, 1974; Jacobs et al., 2007; Mateika et al., 1982; Piekarczyk and Pajaczkowska, 1979) have studied the effect of different parameters on the quality of oxide crystals grown by Czochralski technique. They found that Crystal growth atmosphere composition and melt stoichiometry are strongly influenced on the quality of crystals as well as solid-liquid interface shape. However, the growth of oxides such as Gd3Ga5O12 [Brandle et al., 1972], ZnO [Klimm et al., 2008a], SrLaGaO4 [Pajaczkowska et al., 2001], single crystals by standard melt growth techniques are difficult due to their high melting point and thermal decomposition upon heating. Otherwise, if the composition of melt would be serious, the chemical composition of these oxides melt will depart from the congruent point and superfluous components would become the harmful impurities for crystal growth. Due to the volatilization of oxide melts and the necessity of an oxidizing atmosphere, the crucible that contains the melt should consist of a noble metal. The only materials that have been found to tolerate these violent conditions are the platinum group of metals and their alloys (Day, 1963; Cockayne, 1974). Although the growth from platinum crucible can be performed in presence of oxygen, unfortunately, platinum with Tm=2042 K and its alloys cannot use for mostly oxides because of their high melting point (Darling et al., 1970). Very often platinum or alloys of platinum are used only for oxides with low melting point (T 2250 Ko (Handley,1986), iridium crucible are widely used for growing high melting oxides such as GGG, Al2O3 and ZnO. It is important to note that, iridium is more sensitive to
Update on drug information centers in the United States (1981)

Journal Article Update on drug information centers in the United States Get access Jack M. Rosenberg, Pharm.D., Ph.D., Jack M. Rosenberg, Pharm.D., Ph.D. Associate Professor of Clinical Pharmacy and Director International Drug Information Center Address reprint requests to Dr. Rosenberg at the International Drug Information Center, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, 75 DeKalh at University Plaza, Brooklyn, NY 11201. Search for other works by this author on: Oxford Academic Google Scholar Harold L. Kirschenbaum, Pharm.D., M.S., Harold L. Kirschenbaum, Pharm.D., M.S. Assistant Professor of Clinical Pharmacy and Assistant Director International Drug InformationCenter Search for other works by this author on: Oxford Academic Google Scholar Nicholas A. Labella, Jr, M.S. Nicholas A. Labella, Jr, M.S. formerly Clinical Associate Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 38, Issue 10, 1 October 1981, Pages 1522–1524, https://doi.org/10.1093/ajhp/38.10.1522 Published: 01 October 1981
Distortion program-size complexity with respect to a fidelity criterion and rate-distortion function (1993)

A novel concept of distortion Kolmogorov-chaitin complexity is proposed. Bearing analogy to ordinary Kolmogorov-Chaitin complexity that represents the information content of a single message, distortion Kolmogorov-Chaitin complexity can be regarded as the amount of information about a single message that must be conveyed in order to reproduce it with a bounded distortion. This explanation is justified by the properties of distortion Kolmogorov-Chaitin complexity and the equivalences between distortion Kolmogorov-Chaitin complexity and the rate-distortion function, which are analogous to those between ordinary Kolmogorov-Chaitin complexity and the Shannon entropy. Some implications for universal almost sure data compression are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Clinically acceptable agreement between the ViMove wireless motion sensor system and the Vicon motion capture system when measuring lumbar region inclination motion in the sagittal and coronal planes (2017)

We found a clinically acceptable level of agreement between these two methods for measuring standing lumbar inclination motion in these two cardinal movement planes. Further research should investigate the ViMove system's ability to measure lumbar motion in more complex 3D functional movements and to measure changes of movement patterns related to treatment effects.
Comparative Analysis of Five Highly Conserved Target Sites Within the HIV-1 RNA for Their Susceptibility to Hammerhead Ribozyme-Mediated Cleavage <i>In Vitro</i> and <i>In Vivo</i> (1996)

Moloney murine leukemia virus (MMLV)-derived pUCMoTiN-based retroviral vectors were engineered to allow constitutive and Tat (trans-activator of transcription)-inducible expression of five hammerhead ribozymes targeted against highly conserved sequences within the group antigen (Gag), protease (Pro), reverse transcriptase (RT), tat, and envelope (Env) coding regions of human immunodeficiency virus type-1 (HIV-1) RNA. Amphotropic retroviral vector particles were used to infect a human CD4+ lymphocyte-derived MT4 cell line. The pool of stable MT4 transductants expressing these ribozymes were each tested for their susceptibility to HIV-1 infection. RzTat conferred no protection to MT4 cells. RZGag and RzRT completely inhibited virus multiplication for 6 days. RzPro and RzEnv conferred the best protection, as they completely inhibited virus production for 12 and 15 days, respectively. No correlation was found between the degree of HIV-1 resistance conferred and the ability of these ribozymes to cleave their target RNA in vitro. From RzPro-expressing HIV-1-infected cells following virus escape, RzPro and target RNA sequences were amplified and checked for cleavage in vitro. The ribozyme expressed in these cells was shown to cleave the corresponding target RNA. Thus, a mutation in the ribozyme or target RNA does not seem to be the mechanism underlying virus escape.
Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model (2018)

These data indicate a similar beneficial potential of topical high dose PR022 HOCl (0.1%) in gel and tofacitinib, in a translational murine model of atopic dermatitis.
Segmentation of spoken dialogue by interjections, disfluent utterances and pauses (2002)

The paper attempts to segment spontaneous speech of human to human spoken dialogues into a relatively large unit of speech, that is, a sub phrasal unit segmented by interjections, disfluent utterances and pauses. A spontaneous speech model incorporating prosody was developed, in which three kinds of speech segment models and the transition probabilities among them were specified. The segmentation experiments showed that 87.6% of the segment boundaries were located correctly within 50 msec, 81.2% within 30 msec, which showed 10.1 point increase in performance comparing with the initial model without prosodic information.
Endothelial Cells from Human Fetal Brain Microvessels May Be Cholinoceptive, but Do Not Synthesize Acetylcholine (1991)

Brain homogenate, cerebral microvessels, and endothelial cells (ECs) were prepared from 15-18-week-old human fetuses and analyzed biochemically for the presence of elements of the cholinergic system [acetylcholinesterase (AChE), choline acetyltransferase (ChAT), and butyrylcholinesterase]. The ECs were cultured, and their purity was checked by light microscopic immunohistochemistry with the application of anti-human factor VIII and glial fibrillary acidic protein. The highest activity of ChAT was found in the brain homogenate and the lowest in the microvessel fraction. No ChAT activity could be detected in the cultured ECs, despite the presence of high AChE activity. It is suggested that human brain ECs may be under the control of acetylcholine released from cholinergic nerve terminals but that the cells do not produce the transmitter itself. In coculture experiments, when ECs were plated on the upper surface of a polycarbonate filter and glial cells were seeded on the lower surface, the electric resistance was measured. During the culture period, the resistance first increased up to 5 days in vitro (297 +/- 17 ohm.cm2) but later gradually declined. These results demonstrate that human ECs cocultured with glial cells provide a useful model for study of the function of the blood-brain barrier in vitro.
Precise Near-to-Head Acoustics with Binaural Synthesis (2006)

For enhanced immersion into a virtual scene more than just the visual sense should be addressed by a Virtual Reality system. Additional auditory stimulation appears to have much potential, as it realizes a multisensory system. This is especially useful when the user does not have to wear any additional hardware, e.g., headphones. Creating a virtual sound scene with spatially distributed sources requires a technique for adding spatial cues to audio signals and an appropriate reproduction. In this paper we present a real-time audio rendering system that combines dynamic crosstalk cancellation and multi-track binaural synthesis for virtual acoustical imaging. This provides the possibility of simulating spatially distributed sources and, in addition to that, near-to-head sources for a freely moving listener in room-mounted virtual environments without using any headphones. A special focus will be put on near-to-head acoustics, and requirements in respect of the head-related transfer function databases are discussed.
Efficacy of a touchscreen computer based family cancer history questionnaire and subsequent cancer risk assessment (2000)

The touchscreen computer family history questionnaire allows easy collection of family history information, provision of risk assessments to a broad population, and promotes increased awareness of familial risk and appropriate surveillance.