gebhart/patrepeval huggingface dataset:
A robustness property of DOA estimators based on covariance (1994)

A simple general formula is derived under a Gaussian model for the asymptotic covariance of direction-of-arrival (DOA) estimators based on the covariance of the sensor array data. It is then established that the same formula remains valid for a wide class of statistical models for source signals. Hence, under mild assumptions, the asymptotic performance of most high-resolution covariance-based DOA estimators is independent of the distribution of the source signals.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
OS1901 Influence of Crystal Orientation on Sub-Grain Scale Adhesion Strength of Interface between Cu and Insulation Layer in LSI Interconnect Systems (2012)

Sub-crystal grain scale adhesion strength of the interface between Cu line and insulation layer in LSI interconnect systems was evaluated by performing fracture test with 100nm-scale cylindrical specimens fabricated by focused ion beam. Furthermore, the correlation between interface adhesion strength and crystal orientation was investigated by observing the electron backscattering diffraction image at the footprint of the specimen after the fracture test. As a result, the evaluated adhesion strength strongly depends on the crystal orientation of Cu surface facing to the interface. This result suggests that the scatter of the local adhesion strength is caused by the microstructure of Cu line.
A model-based back-end for air quality data management (2013)

In this paper we present a hybrid model for real-time query processing over data stream collected by mobile air quality sensors. First, we introduce a novel indexing scheme for representing air quality and use it for generating and evaluating a static model over a yearly dataset. Then, this model is combined with a dynamic nearest-neighbor approach for real-time updates, and implemented into the Global Sensor Network (GSN) middleware, with added support for model queries.
A phase II trial of letrozole and trastuzumab for ER and/or PgR and HER2 positive metastatic breast cancer: Final results (2005)

596 Background: About 50% of HER2+ breast cancers exhibit ER coexpression and HER2 signaling may impair responses to endocrine treatment. A Phase II trial was therefore conducted to examine trastuzumab (TRAS) with letrozole (LET) in patients with ER and HER2 positive advanced disease. Methods: Postmenopausal women with ER and/or PR+, HER2 IHC 2–3+ or FISH+, measurable (WHO) metastatic breast cancer, ECOG 0–2 and LVEF greater than 50%. Loading dose TRAS within 28 days of initiating aromatase inhibitor (AI). Patients who had been started on other AI were switched to LET. The exclusion criteria were prior AI > 28 days, prior TRAS, cumulative anthracycline > 360 mg/m2, brain metastases, visceral crisis, prior radiation to only evaluable lesion, severe comorbidity or other malignancies and > 1 prior chemotherapy for metastatic disease. All responses at 3 months were confirmed with a second CT scan at six months. Results: 32 patients were accrued. The majority had visceral metastases (72%). Twenty tumors were either HER2 3+ and/or FISH+, the rest were either 2+ to 3+ or 2+. 30 were ER+ and 2 ER-, PgR+. Twenty-six had received prior tamoxifen the remaining six were endocrine-therapy naïve. Of 27 patients evaluable for response at the time of this report, there were 2 CR, 5 PR, 7 SD (at 24 weeks) and 13 PD giving an objective RR of 25% and clinical benefit rate (response or stable disease) of 52%. Median duration of response was 73 weeks (range 47 to 180+). The median overall TTP was 32 weeks (range 6 to 180+ weeks). Of the remaining 5 patients, 2 have been followed for less than 24 weeks, 1 came off study early for toxicity and 2 withdrew consent before response could be assessed. 7 patients are still on therapy. The toxicities were mainly grade 1 to 2. The only serious complication was cardiomyopathy in a patient with prior doxorubicin and left chest wall irradiation. Conclusions: TRAS with LET was well-tolerated and active with durable responses in about 1 in 4 patients. However, despite dual targeting, early progression occurred in 1 in 2 patients suggesting TRAS and AI have common resistance pathways. A final update and a central HER2 FISH analysis will be presented at the meeting. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis Genentech, Novartis Genentech, Novartis
ChemInform Abstract: Sr<sub>21</sub>Bi<sub>8</sub>Cu<sub>2</sub> (CO<sub>3</sub>)<sub>2</sub>O<sub>41</sub>, a Bi<sup>5+</sup> Oxycarbonate with an Original 10L Structure. (2014)

Abstract The new layered title compound is synthesized by solid state reaction of Bi 2 O 3 , SrCO 3 , SrO, SrO 2 , and CuO (4:1:10:10:2; 900 °C, 15 h).
Use of pentoxifylline in assisted reproductive technology (1995)

Methods for improving the fertilizing potential of the spermatozoa in human in-vitro fertilization (IVF) include the stimulation of sperm function in vitro. Metabolic stimulation in vitro has become a major issue in assisted reproductive technology (ART). Here, we review our research on the unselective use of pentoxifylline in IVF for male-factor infertility. Data from our controlled studies indicate that an indiscriminate use of 3.6 mM pentoxifylline, alone or in combination with 3.0 mM 2-deoxyadenosine, is not beneficial in enhancing fertilization rates in zero and poor in-vitro fertilizers or in the presence of antisperm antibodies. An assessment of the effects of pentoxifylline on sperm function prior to IVF may ensure a more rational use of these compounds in selected cases undergoing ART. At present, however, controlled studies in subgroups of patients selected by functional testing are still lacking.
<i>Lymphatic Tissue Engineering</i> (2008)

In the last 5 years major advances have been made in the field of tissue engineering. However, while engineering of tissues from nearly every major system in the body have been studied and improved, little has been done with the engineering of viable lymphatic tissues. Recent advances in understanding of lymphatic biology have allowed the easy isolation of pure lymphatic cell cultures, increasing, in turn, the ability to study lymphatic biology in greater detail. This has allowed the elucidation of lymphatic properties on the structural, cellular, and molecular levels, making possible the successful development of the first lymphatic engineered tissues. Among such advances are the engineering of lymphatic capillaries, the development of a functioning bioreactor designed to culture lymph nodes in vitro, and in vivo growth of lymphatic organoids. However, there has been no research on the engineering of functional lymphangions. While the advances made in the study of lymphatic biology are encouraging, the complexities of the system make the engineering of certain functional lymphatic tissues somewhat more difficult.
Neutron and Charged-Particle Induced Cross Sections for Radiochemistry in the Region of Samarium, Europium, and Gadolinium (2004)

We have developed a set of modeled nuclear reaction cross sections for use in radiochemical diagnostics. Systematics for the input parameters required by the Hauser-Feshbach statistical model were developed and used to calculate neutron and proton induced nuclear reaction cross sections in the mass region of samarium, europium and gadolinium (62 {le} Z {le} 64, 82 {le} N {le} 96).
Reverse osmosis characteristics of composite membranes prepared by plasma polymerization of allylamine. Effects of deposition conditions (1977)

A study has been conducted to determine the effects of flow configuration and reaction conditions on the performance of composite reverse osmosis membranes prepared by plasma polymerization of allylamine over a porous polymer substrate. It was established that superior membranes were obtained by using a gas-flow configuration avoiding direct monomer flow over the substrate. High rejections of NaCl could be attained when the plasma-deposited film was sufficiently thick to bridge all of the pores in the substrate. It was observed that in addition to influencing the rate of polymerization, the conditions used to sustain the plasma also affected the reverse osmosis characteristics of the deposited film. The effects of these conditions and other preparation procedures are discussed. Attempts to use infrared spectroscopy and ESCA to identify the relationship between polymer structure and reverse osmosis performance were not successful. ESCA did prove useful, though, in confirming an earlier postulated hypothesis that degradation of reverse osmosis performance is associated with the hydrolysis of nitrogen-containing structures in the plasma-deposited film.
Total Synthesis of 6-Trans, 10-cis and (plus or minus) -6-Trans,8-cis Isomers of Leukotriene B (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of 6-Trans, 10-cis and (plus or minus) -6-Trans,8-cis Isomers of Leukotriene BE. Corey, Paul Hopkins, John Munroe, Anthony Marfat, and Shun-ichi HashimotoCite this: J. Am. Chem. Soc. 1980, 102, 27, 7986–7987Publication Date (Print):December 1, 1980Publication History Published online22 December 2003Published inissue 1 December 1980https://pubs.acs.org/doi/10.1021/ja00547a600https://doi.org/10.1021/ja00547a600research-articleACS PublicationsRequest reuse permissionsArticle Views419Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Decreased sialylation of <scp>IgA1</scp> <i><scp>O</scp></i>‐glycans associated with pneumococcal hemolytic uremic syndrome (2013)

Hemolytic uremic syndrome (HUS) in children is usually caused by Shiga-like toxin-producing Escherichia coli, but approximately 5% of cases are caused by invasive pneumococcal infection (P-HUS). Reported herein is the case of a 9-month-old HUS patient with pneumococcal meningitis who needed hemodialysis for 12 days. Decreased sialylation was characterized in both transferrin N-glycans and IgA1 O-glycans, analyzed in the acute phase on mass spectrometry, consistent with S. pneumonia-produced sialidases hydrolyzing both α2,3- and α2,6-linked sialic acids. The method will complement the T-antigen activation test and help to understand the molecular pathology related to P-HUS.
Purification and characterization of a Galactomyces reessii hydratase that converts 3-methylcrotonic acid to 3-hydroxy-3-methylbutyric acid (2002)

Cell free extracts of Galactomyces reessii contain a hydratase as the key enzyme for the transformation of 3-methylcrotonic acid to 3-hydroxy-3-methylbutyric acid. Highest levels of hydratase activity were obtained during growth on isovaleric acid. The enzyme, an enoyl CoA hydratase, was purified 147-fold by precipitation with ammonium sulphate and successive chromatography over columns of DE-52, Blue Sepharose CL-6B and Sephacryl S-200. During purification, hydratase activity was measured spectrophotometrically (OD change at 263 nm) for 3-methylcrotonyl CoA and crotonyl CoA as substrates. The enzyme displayed highest activity with crotonyl CoA with a Kcat of 1,050,000 min(-1). The ratio of crotonyl CoA to 3-methylcrotonyl CoA activities was constant (20:1) during all steps of purification. The Kcat for crotonyl CoA was also about 20 times greater than the Kcat for 3-methylcrotonyl CoA (51,700 min(-1). The enzyme had pH and temperature optima at 7.0 and 35 degrees C, a native Mr of 260 +/- 4.5 kDa and a subunit Mr of 65 kDa, suggesting that the enzyme was a homotetramer. The pI of the purified hydratase was 5.5, and the N-terminal amino acid sequence was VPEGYAEDLLKGKMMRFFDS. Hydratase activity for 3-methylcrotonyl CoA was competitively inhibited by acetyl CoA, propionyl CoA and acetoacetyl CoA.
A multiscale and non-conforming interface coupling technique for the global-local analysis of heterogeneous structures (2019)

International audience
Additional polymorphism at a CHR 9 reference locus (D9S12) (1992)

Journal Article Additional polymorphism at a CHR 9 reference locus (D9S12) Get access M.A.R. Yuille, M.A.R. Yuille * University of Cambridge, Department of PathologyTennis Court Road, Cambridge CB2 1QP, UK *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar D.R. Goudie, D.R. Goudie University of Cambridge, Department of PathologyTennis Court Road, Cambridge CB2 1QP, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar N.A. Affara, N.A. Affara University of Cambridge, Department of PathologyTennis Court Road, Cambridge CB2 1QP, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar M.A. Ferguson-Smith M.A. Ferguson-Smith University of Cambridge, Department of PathologyTennis Court Road, Cambridge CB2 1QP, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 1, Issue 5, August 1992, Page 351, https://doi.org/10.1093/hmg/1.5.351-a Published: 01 August 1992
Requirements of a costimulus for IL-4-induced IgE class switching in murine B cells activated via antigen receptors: effectiveness of 8-mercaptoguanosine (1996)

In the present paper, we investigated the requirements for the induction of IgE responses in murine B cells stimulated via surface Ig receptors by trinitrophenyl (TNP)-LPS or F(ab')2 of anti-mouse IgM (anti-mu) Abs. When murine B cells were cultured with 0.2 microgram/ml TNP-LPS, the secretion of anti-TNP IgM, but not that of IgG1 or IgE, was induced. It should be noted that IL-4, alone or in combination with IL-2 or IL-5, was not sufficient for inducing IgE class switching in these B cells, in contrast to the cells activated polyclonally with 20 micrograms/ml LPS, suggesting that an additional signal is required under the former conditions. After extensive screening of costimuli for inducing IgE in cooperation with IL-4, we found that 8-mercaptoguanosine (8-SGuo), a potent B cell activator, was effective. The addition of 8-SGuo to TNP-LPS-stimulated B cell cultures resulted in the secretion of both anti-TNP IgM and IgG1, but not anti-TNP IgE. Anti-TNP IgE formation was induced only when 8-SGuo was added in combination with IL-4, whereas 8-SGuo plus IL-4 failed to induce IgE secretion in the absence of TNP-LPS. Similar requirements for 8-SGuo and IL-4 for IgE formation were observed when B cells were stimulated with anti-mu. It was revealed that induction of the IgE responses was accompanied by increased frequency of surface IgE+ B cells and the expression of germline and productive epsilon transcripts. In B cells stimulated with anti-mu plus IL-4, 8-SGuo was shown to enhance the expression of the B cell-specific activator protein gene that is thought to be required in IL-4-dependent germline epsilon transcription.
Stress field design in vibro-acoustography beam forming (2004)

Vibro-acoustography produces images of the acoustic response of a material to a localized harmonic motion generated by ultrasound radiation force. Proper beam forming for the stress field of the probing ultrasound is very important because it determines the resolution of the imaging system. Three beam forming geometries are studied: amplitude modulation, confocal, and x-focal. The profiles of radiation stress amplitude on focal plane and beam axis are derived from each geometry's pressure field. The theory is validated by experiments where a small sphere is scanned in all geometries. Sphere motion measured by a laser vibrometer is used to infer the exerted radiation stress. The theory and experimental technique may be useful in future transducer design for vibro-acoustography.
Vapor-Phase Hydration of 2-Butene and Bultanol (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-Phase Hydration of 2-Butene and BultanolC. B. Dale, C. M. Sliepcevich, and R. R. WhiteCite this: Ind. Eng. Chem. 1956, 48, 5, 913–918Publication Date (Print):May 1, 1956Publication History Published online1 May 2002Published inissue 1 May 1956https://pubs.acs.org/doi/10.1021/ie50557a033https://doi.org/10.1021/ie50557a033research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Correlation between Molecular Marker Distance and Hybrid Performance in U.S. Southern Long Grain Rice (1997)

Improving grain and milling yields of long‐grain rice ( Oryza sativa L.) continues to be a major objective of southern U.S. breeding programs. The objective of this study was to determine the relationship between molecular marker polymorphism of the parents and performance of the F 1 hybrids. A diallei cross was made by intermating eight lines commonly used in U.S. southern long‐grain rice breeding programs. The 28 F 1 hybrids and the parents were evaluated for rough rice yield, head rice percentage, and head rice yield in replicated field trials. Very little heterosis was detected among hybrids for head rice percentage, whereas heterosis was high for rough rice yield and head rice yield. A survey for DNA polymorphisms with 82 RFLPs and 26 microsatellites revealed high levels of variation among the eight parents. A cluster analysis resolved these eight lines into indica (one line) and tropical japonica (seven lines) rice subgroups. A majority of the markers detected statistically significant effects on one or more traits by an analysis of variance. Marker F 1 heterozygosity was highly correlated with rough rice yield (0.79**) and head rice yield (0.82**), and was also significantly correlated with heterosis of these two traits (0.47*, 0.58**, respectively). However, the correlations were largely attributed to the concurrence between high levels of heterozygosity and high performance in crosses between the indica variety Jasmine 85 and the remaining seven lines. Compared with the data published in previous studies, it was concluded that the level of correlations between marker distance and hybrid performance is dependent on the germplasm used.
Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center (1996)

Both rapid B-cell proliferation and programmed cell death (PCD) occur during the differentiation and selection of B cells within the germinal center. To help elucidate the role of Bcl-x in B-cell antigen selection and PCD within the germinal center, we examined its expression in defined B-cell populations and by immunochemistry of tonsil tissue. Purified B-cell fractions enriched for centrocytes express high amounts of Bcl-x and relatively low amounts of Bcl-2, whereas fractions enriched for centroblasts lack significant levels of both proteins. Consistent with this observation, immunocytochemistry localized Bcl-x within cells scattered throughout the germinal center. Stimulation of tonsil B cells with either CD40 or Staphylococcus aureus Cowan increase bcl-x mRNA and protein levels. Treatment of a cell line with a germinal center phenotype (RAMOS) or the tonsillar B-cell centroblast fraction with CD40 rapidly increased Bcl-x levels and partially rescued B cells from PCD. These data suggest that Bcl-x rather than Bcl-2 may rescue centrocytes during selection in the germinal center.
[The influence of psychological factors on the immune system and immunological diseases]. (1996)

During the last 10-20 years it has become clear that the immune system not only protects the individual against potentially harmful intruders but also interacts with both the nervous and endocrine systems. Today we know that immune competent cells have receptors for hormones and neurotransmitters, and that cytokine receptors are expressed in certain areas of the brain. Furthermore, in many animal models immune suppression has been induced by classical conditioning. Several in vitro studies have shown signs of reduced immunity in individuals during acute and chronic stress. Some studies have also indicated that chronic stress may increase the risk of infections and cancer. On the other hand, various psychotherapeutic techniques appear to strengthen the immune system. As for immunological disease, we know that psychological factors are important in the case of allergic asthma. Moreover, serious life events prior to onset of disease are reported more frequently by seronegative than by seropositive rheumatoid arthritis patients. Prospective studies have shown that psychotherapeutic intervention can reduce disability in rheumatoid arthritis patients, but disease activity is diminished only rarely.
The microbiology and physiology of anaerobic fermentations of cellulose: Progress report, November 1988--July 1989 (1989)

In this progress report we describe an integrated study of some individual anaerobic bacteria that are important for the complete conversion of cellulose to methane and CO/sub 2/, and of enzymes such as formate dehydrogenase, hydrogenase and CO dehydrogenase which are of special concern to syntropic interactions between the bacteria.
Fault location for teed circuits with mutually coupled lines and series capacitors (2004)

This paper investigates the problem of fault location in teed circuits. Previous work presented in C.Y. Evrenssoglu and A. Abur (Oct. 200), has successfully extended the discrete wavelet transform (DWT) based fault location technique of F.H. Magnago and A. Abur (Oct. 1998) to the case of teed circuits. In this paper, additional challenges introduced in the presence of MOV protected series capacitors and/or mutually coupled line sections in teed circuits are addressed. DWT based fault location procedures are developed and tested for these special cases. Fault signals simulated by ATP are used to validate the new fault location procedure under various scenarios.