gebhart/patrepeval huggingface dataset:
Abstract 16276: A Web-based Tool for Predicting Acute Kidney Injury in ST-elevation Myocardial Infarction (2015)

ST-elevation myocardial infarction (STEMI) requires emergent diagnostic catheterization and therapeutic percutaneous coronary intervention. These therapies may cause acute kidney injury (AKI), a serious procedural complication that contributes to morbidity and mortality in STEMI patients. Identifying patients at risk for renal complications may save lives and reduce healthcare costs, but there is no validated tool for predicting AKI in STEMI patients. Methods: The UT-Methodist STEMI program is a racially diverse series of 1144 consecutive patients. We derived and validated the UT-AKI score to predict the risk of AKI in patients referred for STEMI (and not currently on dialysis). AKI was categorized by the modified AKI Network and RIFLE indices. The UT-AKI score was derived from logistic regression analysis performed on a randomly selected derivation dataset using variables with significant univariate relationships to AKI and markers of renal function. Receiver operator characteristic (ROC) curves for the UT-AKI were assessed in the derivation and validation datasets. Statistical significance was measured by appropriate parametric and non-parametric tests; a p<0.05 was considered significant. Results: The incidence of AKI was similar in patients undergoing diagnostic catheterization with or without PCI (12% vs. 14%, p=0.34). ROC curve analysis of the validation data set showed that the UT-AKI score (AUC 0.76 (95% CI 0.70-0.82)) was significantly better at classifying patients at risk for AKI than the ACEF (AUC 0.65 (95% CI: 0.58-0.73)), AGEF (AUC 0.65 (95% CI: 0.58-0.72)), or Mehran (AUC 0.67 (95% CI: 0.59-0.75)). The classification accuracy for the UT-AKI index was comparable for milder and severe forms of AKI. Conclusions: In the largest analysis of STEMI patients to date, we found no significant difference in the risk of AKI from PCI vs. diagnostic catheterization. The validation study indicates that the UT-AKI index was significantly better than other scores at classifying which patients will develop AKI. Accurate prediction of AKI may help physicians to personalize therapies and develop novel strategies to reduce kidney injury in patients with STEMI.
Stability of a pH-sensitive polymer matrix (1990)

A ratiometric pH-sensitive fluorescent dye (hydroxypyrenetrisulfonic acid) was covalently attached to an acrylamide polymer. These pH-sensitive copolymers were either covalently bonded to the end of an optical fiber or polymerized into separate gels. Long-term, accelerated aging studies were performed on the fibers and gels in 43{degree}C distilled H{sub 2}O. The fiber-immobilized optrodes gave good pH responses for up to 2 months. The pH-sensitive gels were physically attached to optical fibers and gave very good pH responses for over one year. These physically immobilized, one-year-old, pH-sensitive copolymers provided optrodes with linear pH responses between pH 6 and 8 and resolution greater than 0.25 pH unit. A simple photostability experiment on these optrodes showed that they were very photostable. The results of this study indicate that pH-sensitive copolymers in a simple optrode design can be employed as pH sensors with useful lifetimes exceeding one year. 11 refs., 6 figs.
Under feedback and interference constraints uplink power control in two-tier networks (2016)

This paper considers optimum uplink power control policy that maximizes total sum-rate without any interference cancellation techniques under interference and feedback constraints at next generation communication systems. System model has two tier and it is assumed that the feedback channel between these tiers has finite capacity. Second tier users (STU) cause interference on first tier users (FTU) and base station (FTB) while communicating with second tier base station (STB). In proposed scenario, this interference power on first tier network is limited at a certain level. To this end, two different feedback policies are proposed. The first one is determining the K smallest interference channel coefficients of STUs by FTU and sending them to STB. The other policy is that STB requests the interference channel information of K users that have the best direct channel state from FTB. Due to proposed scenario is not a convex problem, it is solved with DC programming well-studied in literature before and performances of proposed feedback policies are compared.
A new microcontroller based solar energy conversion modular unit (2002)

This paper presents the design and the implementation of a new microcontroller-based solar energy conversion modular unit. The unit consists of an array of solar panels, a step-up chopper, a single-phase inverter, an AC mains power source and a microcontroller-based control unit. The novelty of this unit is that the switching device of the chopper is not only used for power conversion but also for maximum power point (MPP) detection. In existing MPP trackers, the MPP is detected by hardware. The parameters of such hardware are subject to changes of environmental conditions. In the new unit, the MPP is determined by a simple embedded software. With this new approach the modularization of the conversion from solar power to electric power at its maximum power point can be made more compact and more reliable.
Release of Contracting Autacoids by Aortae of Normal and Atherosclerotic Rabbits (1992)

The aim of our study was to examine the release of various lipid and peptide contracting autacoids by aortae of normal and atherosclerotic rabbits. Leukotriene (LT) E4, an enzymatic derivative of LTC4, thromboxane (Tx) B2, and endothelin-1 (ET-1) were measured by radioimmunoassay techniques in aortic preparations of normal and cholesterol-fed rabbits. Intact aortae of normal rabbits incubated with the calcium ionophore A23187 for 1 h at 37 degrees C released LTE4 and TxB2 (22 +/- 3.5 and 14.8 +/- 2 pg/mg of tissue, respectively, mean +/- SEM, n = 33). Removal of aortic endothelium was associated with a significant reduction in LTE4 (44%) and TxB2 (58%) release. In aortic preparations from cholesterol-fed rabbits, the release of LTE4 was significantly enhanced (41 +/- 8 pg/mg of tissue, mean +/- SEM, n = 27) whereas TxB2 was not significantly altered. No detectable amounts of ET-1 were measured after 1 h of incubation. However, at 4 h, an endothelium-dependent release of ET-1 from normal aortae was demonstrated. In atherosclerotic aortae, ET-1 release was significantly higher than in controls (10 +/- 1.3 vs. 5 +/- 0.5 pg/cm2, mean +/- SEM, n = 16). We conclude that enhanced formation of vasoconstrictor autacoids may contribute to altered vasomotion of atherosclerotic blood vessels.
Surgical and Pathologic Complications Associated with Peritoneovenous Shunts in Management of Malignant Ascites (1985)

SOUTER, ROBIN G.; WELLS, CLIVE; TARIN, DAVID; KETTLEWELL, MICHAEL G. W. Author Information
<title>Smoothing and matching of 3-D space curves</title> (1992)

We present a new approach to the problem of matching 3-D curves. The approach has an algorithmic complexity sublinear with the number of models, and can operate in the presence of noise and partial occlusions. We make use of non-uniform B-spline approximations, which permits us to better retain information at high curvature locations. The spline approximations are controlled (i.e., regularized) by making use of normal vectors to the surface in 3-D on which the curves lie, and by an explicit minimization of a bending energy. These measures allow a more accurate estimation of position, curvature, torsion, and Frenet frames along the curve. The computational complexity of the recognition process is considerably decreased with explicit use of the Frenet frame for hypotheses generation. As opposed to previous approaches, the method better copes with partial occlusion. Moreover, following a statistical study of the curvature and torsion covariances, we optimize the hash table discretization and discover improved invariants for recognition, different than the torsion measure. Finally, knowledge of invariant uncertainties is used to compute an optimal global transformation using an extended Kalman filter. We present experimental results using synthetic data and also using characteristic curves extracted from 3-D medical images. An earlier version of this paper was presented at ECCV'92.
Class B+ GPON extended to 44dB while maintaining 15dB optical budget difference (2008)

Optical amplifiers are evaluated as extender boxes for GPON ClassB+ systems. We obtained a total budget of 44dB from OLT to ONUs while maintaining 15dB optical budget difference between ONUs.
ChemInform Abstract: Ceragenins: Cholic Acid Based Mimics of Antimicrobial Peptides (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Globin chain synthesis in single erythroid bursts from cord blood: studies on gamma leads to beta and G gamma leads to A gamma switches. (1980)

Erythroid bursts from cord or adult blood were grown in methylcellulose cultures (3 international units of erythropoietin per plate). On day 13, single bursts were picked up and reincubated for 16-24 hr with [3H]leucine. Radioactive globin chains [alpha,beta,G gamma, and A gamma (Ala-136)] were analyzed by either isoelectric focusing on polyacrylamide gels and fluorography or carboxymethylcellulose chromatography. In all cases, alpha to non-alpha globin radioactivity ratios were close to 1. In single cord blood bursts, the values of both gamma-to-beta and G gamma-to-A gamma ratios were spread over a large spectrum and further characterized by a continuous rather than a bimodal distribution. Morever, the G gamma-to-A gamma ratios demonstrated in single bursts appeared to be directly correlated with the respective gamma-to-beta ratios. These data suggest that both the gamma leads to beta and the G gamma leads to A gamma switches are mediated via mechanisms modulating the relative activities of the different genes in the non-alpha globin gene cluster rather than via selection of clones committed to the preferential synthesis of beta and A gamma globins. In contrast with the results obtained with cord blood, individual adult blood bursts synthesize a lower and hence relatively more uniform amount of gamma globin chains.
Synthesis of 3‐(1H‐Benzimidazol‐2‐yl)‐5‐isoquinolin‐4‐ylpyrazolo[1,2‐b]pyridine, a Potent Cyclin Dependent Kinase 1 (CDK1) Inhibitor. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of a Synthesis For a Long-Term Oxazolidinone Antibacterial (2008)

Linezolid, compound 1, is a member of the oxazolidinone class of antibacterials and has had recent clinical interest due to its potential use as a long-term treatment for bacterial infection. Detailed herein are improvements to the original synthesis to enable phase I clinical trials. Of particular interest is the preparation of a key oxindole subunit utilizing a Pd-mediated cyclization. Optimization of the synthesis of the oxindole included the use of trifluorotoluene as the solvent.
LLE Review quarterly report, July--September 1992. Volume 52 (1992)

This volume of the LLE Review, covering the period July--September 1992, contains articles on methods of balancing the beam power on the OMEGA Upgrade and on the damping of ion-sound waves in laser-produced plasmas. The advanced technology section includes reports on optical nonlinearities in high-temperature superconductors, a method of increasing gas retention time for laser-fusion targets, and a study of stimulated Raman scattering of laser beams in air. Highlights of the research reported in this issue are: An efficient method has been developed for balancing the power in the 60 beams of the OMEGA Upgrade. The method can achieve 2% power balance for both main and foot beams using only four system shots. A study of ion-sound-wave damping has substantially revised and expanded our knowledge of this effect. The damping of ion waves can have important consequences for laser-plasma interaction. The use of femtosecond laser pulses to study the properties of thin-film, high-temperature superconductors is discussed. A method for increasing the gas retention time of polymer-shell laser-fusion targets by overcoating them with a thin layer of aluminum is described. A code has been developed to study stimulated rotational Raman scattering in high-power laser beams propagating through air.
Spectroscopic temperature measurements of air breakdown plasma using a 110 GHz megawatt gyrotron beam (2012)

Temperature measurements are presented of a non-equilibrium air breakdown plasma using optical emission spectroscopy. A plasma is created with a focused 110 GHz 3 μs pulse gyrotron beam in air that produces power fluxes exceeding 1 MW/cm2. Rotational and vibrational temperatures are spectroscopically measured over a pressure range of 1–100 Torr as the gyrotron power is varied above threshold. The temperature dependence on microwave field as well as pressure is examined. Rotational temperature measurements of the plasma reveal gas temperatures in the range of 300–500 K and vibrational temperatures in the range of 4200–6200 K. The vibrational and rotational temperatures increase slowly with increasing applied microwave field over the range of microwave fields investigated.
Development of the High Speed Quench-Detecting System Using a Digital Signal Processor. (1993)

The conventional electric quench-detecting system of AC superconducting coil is vulnerable
Abstract 15234: Targeted Inhibition of NADPH Oxidase in the Posterior Left Atrium by Nox2 shRNA Decreases Formation of Atrial Fibrillation Substrate in Heart Failure (2013)

Introduction: Oxidative stress is thought to play an important role in the pathogenesis of atrial fibrillation (AF). Recent studies indicate that NADPH oxidase (NOX2) is a major source of reactive ...
CELLULAR LOCALIZATION OF ENDOTHELIN RECEPTOR SUBTYPES IN THE RAT KIDNEY FOLLOWING <i>IN VITRO</i> LABELLING (1996)

1. We have previously shown that [125I]-endothelin (ET) receptor binding is localized almost exclusively to the fenestrated endothelial cells of glomerular capillaries and peritubular capillaries in the rat kidney following systemic administration of the radioligand in vivo. Because of the lack of specific ET receptor binding in other glomerular and tubular structures following in vivo labelling, we undertook further studies, using electron microscopic autoradiography and ET receptor subtype selective ligands, to investigate whether other renal components also contain ET receptor binding and, if so, to determine the cellular localization of the ET receptor subtypes, ETA and ETB, following in vitro labelling. 2. At the electron microscopic level, ET binding sites were localized primarily to the fenestrated endothelium of glomerular and peritubular capillaries of the cortex, inner stripe of the outer medulla and the inner medulla. ET binding sites also occurred overlying renomedullary interstitial cells (RMIC) of the inner medulla. 3. The ETB receptor selective agonist, sarafotoxin 6c (S6c), abolished ET binding in the vascular endothelium throughout the kidney, while the ETA receptor selective antagonist, BQ123, was without effect. Both BQ123 and S6c partially inhibited the binding in the RMIC of the inner medulla. 4. These results indicate that ET receptor binding in the fenestrated endothelium in the glomerular capillaries and peritubular capillaries belongs mainly to the ETB subtype, whereas both ETA and ETB subtypes are present in the RMIC.
Physical exercise and immune system function in cancer survivors (2002)

Additional research is needed to determine if physical exercise in cancer survivors may reduce the risk of cancer recurrence and secondary malignancies and increase survival times.
The role of graduate students in research experience for undergraduates programs (2014)

In this article, we consider the role of graduate students as mentors in research experience for undergraduates (REU) programs, as reflected by a breakout session at the Trends for Undergraduate Research in Mathematical Sciences (TURMS) conference. We consider the benefits of using graduate students to the institution running the program and to the participating undergraduates. We also consider the benefits that the graduate students themselves gain from working in an REU, and we warn of potential problems that can arise when employing graduate students in this context.
Enhanced Contaminated Human Remains Pouch: Initial development and preliminary performance assessments (2011)

The ECHRP provides superior protection from both chemical and biological hazards to various emergency response personnel and human remains handlers.
Adsorption and strain: from the molecule to a coal bed reservoir (2011)

International audience
Rolling Contact Testing of Vapor Phase Lubricants—Part IV: Diffusion Mechanisms© (1999)

Auger depth profile data, obtained from vapor-lubricated T15 bearing steel, were modeled using the solution for diffusion in a semi-infinite pair. A tertiary-butyl phenyl phosphate was used as the vapor lubricant. The primary species undergoing diffusion are iron and carbon. The objective of the experiment was to determine the order of magnitude of the diffusion coefficient and to qualitatively assess what types of diffusion mechanisms are involved. The experimental results indicate that the diffusion profile travels at a velocity equal to the bearing wear rate under dynamic conditions. This is possible if iron diffusions at a faster rate than carbon, i.e., the Kirkendall effect. Analyses of the data were performed using Darken's equations. The results indicate that the diffusion coefficient of iron is of the order of 1 × 10−14 cm2/s at test temperatures of 370° and 430°C. Diffusion is thought to occur via the migration of iron cations through an anionic lattice of polyphosphate and phosphite, i.e., cation diffusion. The diffusion mechanism provides a satisfactory explanation of how several hundred monolayers containing iron can exist in vapor deposition film grown from organophosphorus lubricants. The chemical gradient, ionic attraction, and the extreme stress gradients of the Hertzian contact are thought to contribute to diffusion under dynamic conditions.
Study of Three-Dimensional Internal Flow Distribution in Centrifugal Impeller (1958)

The Flow distribution throughout the passage of the rotating impeller has been studied in detail about two types of the impellers, one is with radial-straight blades and the other is with logarithmic-spiral blades, and the results are presented in the form of relative velocity and direction of flow. In the former case, it is measured by changing numbers of rotation and flow factor, and is compared with the results of two-dimensional potentional theory which has been published. From this results, it is underatood that the flow in the impeller cannot be conjectured by the theories. The real flow at the experiment, especially when flow factor is large, it flows through the impeller with nearly the same angle with the entrance flow angle, and the region of the slowest velocity occurrs at the blade negative side. In the latter case, the flow is comparatively along the blades. The velocity distributions and direction of flow indicate that secondary flows in the boundary layer tend to shift the low-energy air toward the blade negative surface within the passage. There is a counter effect at the casing surfade apparently caused by leakage through the blade to casing clearance space. This results a vortex flow in the passage.
Localization of type I iodothyronine 5'-deiodinase to the basolateral plasma membrane in renal cortical epithelial cells (1991)

Type I iodothyronine 5'-deiodinase is an integral membrane protein catalyzing the phenolic ring deiodination of thyroxine. We recently showed that the substrate binding subunit of this approximately 50-kDa protein is selectively labeled with N-bromoacetyl-L-thyroxine, allowing ready identification of the type I enzyme without the need to maintain catalytic activity. In this study, we used both affinity labeling and catalytic activity to determine the regional distribution of this enzyme in rat kidney and to localize the enzyme to specific plasma membrane domain(s) of renal epithelial cells. The type I enzyme was present exclusively in tubular epithelial cells of the outer renal cortex and co-purified with basolateral plasma membranes; the renal medulla lacked activity. LLC-PK1 cells, derived from the proximal convoluted tubule, have abundant type I 5'-deiodinating activity. We used this homogenous cell line to verify that the type I enzyme was localized to the cytosolic surface of the basolateral membrane. Digitonin permeabilization increased affinity labeling of the enzyme 4-fold, and approximately 75% of the affinity label was incorporated into the 27-kDa substrate binding subunit. Affinity labeling of the type I enzyme in LLC-PK1 cells mimicked the affinity labeling of the substrate binding subunit of type I 5'-deiodinase in rat kidney (Köhrle, J., Rasmussen, U. B., Ekenbarger, D. M., Alex, S., Rokos, H., Hesch, R. D., and Leonard, J. L. (1990) J. Biol. Chem. 265, 6155-6163). Subcellular fractionation of LLC-PK1 cell homogenates showed that both affinity labeled and catalytically active type I enzyme were present on the cytosolic surface of the basolateral region of the renal cell membrane.
Chromosomal imbalances are associated with outcome of <i>Helicobacter pylori</i> eradication in t(11;18)(q21;q21) negative gastric mucosa‐associated lymphoid tissue lymphomas (2007)

Approximately 70% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas can be successfully treated with H. pylori eradication. The translocation t(11;18)(q21;q21) characteristic of MALT lymphoma is recognized as a marker for H. pylori independency, but this marker is found in only a half of the MALT lymphomas resistant to H. pylori eradication. Detailed analyses of the genomic features of eradication resistant as well as responsive groups are important for understanding their molecular basis. We performed array-based comparative genomic hybridization (array-CGH) for 29 gastric MALT lymphomas treated with H. pylori eradication. These comprised ten cases of t(11;18) positive MALT, nine cases of t(11;18) negative MALT with H. pylori dependency, and ten cases of t(11;18) negative MALT with H. pylori independency. Array-CGH analysis demonstrated that no significant genetic alterations were found in t(11;18) positive MALT lymphomas, but numerous genomic alterations were detected in t(11;18) negative MALT lymphomas. Many of these alterations were similar to those found in diffuse large B-cell lymphoma with trisomy 3 being the most recurrent alteration. Within the t(11;18) negative MALT lymphoma without large cell components group, genomic imbalances occurred more frequently in the H. pylori independent than in the H. pylori dependent group (P = 0.02). Genomic imbalances are associated with H. pylori independency in t(11;18) negative gastric MALT lymphomas. They may thus play an important role in the development of H. pylori independency.
Synthesis and Radical Scavenging Activities of Resveratrol Analogs (2013)

Highly substituted polyhydroxylated (E)-stilbenes were synthesized by Mizoroki-Heck reactions and tested for their ability to act as radical scavenger. One of the 56 stilbenes included in this study and investigated in DPPH assays gave an SC50 value of 11.0 μM, hence exhibiting an about 9.3 times higher activity than resveratrol. As shown in a photometric SRB assay using mouse NiH 3T3 fibroblasts, this compound is not cytotoxic up to concentrations of <30 μM.