gebhart/patrepeval huggingface dataset:
Diffusion of Unlike Ions into Liquid Sodium Chloride (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiffusion of Unlike Ions into Liquid Sodium ChlorideJ. O'M. Bockris, S. Yoshikawa, and S. R. RichardsCite this: J. Phys. Chem. 1964, 68, 7, 1838–1841Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/j100789a028https://doi.org/10.1021/j100789a028research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture (2015)

Controlled feeding of glucose has been employed previously to enhance the productivity of recombinant glycoproteins but there is a concern that low concentrations of glucose could limit the synthesis of precursors of glycosylation. Here we investigate the effect of glucose depletion on the metabolism, productivity and glycosylation of a chimeric human-llama monoclonal antibody secreted by CHO cells. The cells were inoculated into media containing varying concentrations of glucose. Glucose depletion occurred in cultures with an initial glucose ≤5.5 mM and seeded at low density (2.5 × 10(5) cells/mL) or at high cell inoculum (≥2.5 × 10(6) cells/mL) at higher glucose concentration (up to 25 mM). Glucose-depleted cultures produced non-glycosylated Mabs (up to 51%), lower galactosylation index (GI <0.43) and decreased sialylation (by 85%) as measured by mass spectrometry and HPLC. At low glucose a reduced intracellular pool of nucleotides (0.03-0.23 fmoles/cell) was measured as well as a low adenylate energy charge (<0.57). Low glucose also reduced GDP-sugars (by 77%) and UDP-hexosamines (by 90%). The data indicate that under glucose deprivation, low levels of intracellular nucleotides and nucleotide sugars reduced the availability of the immediate precursors of glycosylation. These results are important when applied to the design of fed-batch cultures.
A List of Parasites from Marine and Coastal Animals of Florida (1960)

Robert F. Hutton, Franklin Sogandares-Bernal, A List of Parasites from Marine and Coastal Animals of Florida, Transactions of the American Microscopical Society, Vol. 79, No. 3 (Jul., 1960), pp. 287-292
Neural networks that learn temporal sequences by selection. (1987)

A model for formal neural networks that learn temporal sequences by selection is proposed on the basis of observations on the acquisition of song by birds, on sequence-detecting neurons, and on allosteric receptors. The model relies on hypothetical elementary devices made up of three neurons, the synaptic triads, which yield short-term modification of synaptic efficacy through heterosynaptic interactions, and on a local Hebbian learning rule. The functional units postulated are mutually inhibiting clusters of synergic neurons and bundles of synapses. Networks formalized on this basis display capacities for passive recognition and for production of temporal sequences that may include repetitions. Introduction of the learning rule leads to the differentiation of sequence-detecting neurons and to the stabilization of ongoing temporal sequences. A network architecture composed of three layers of neuronal clusters is shown to exhibit active recognition and learning of time sequences by selection: the network spontaneously produces prerepresentations that are selected according to their resonance with the input percepts. Predictions of the model are discussed.
Experiments of Virtual Navigation as a Step in the Development of a Navigation Tool for Blind People. (2007)

Abstract: This paper introduces a formalized definition of an external space representation and proposes a virtual navigation paradigm as a mean for space integration from tactile snapshots. Rules for the design of indoor experimental environments to be used in virtual navigation are presented; they take into account posture modifications of the subject and the cognitive load of the elementary tasks inherent to physical navigation.
MICROMILLING IN MINIMUM QUANTITY LUBRICATION (2012)

Abstract This study investigates micromilling of 316 L stainless steel under minimum quantity lubrication. A laser-based technique was developed to measure spindle runout and assist tool setting for fragile micro cutting tools. Thresholds were established to help select cutting parameters and avoid catastrophic tool failure. Computational fluid dynamics was used to simulate flow of lubricant microdroplets around a rotating tool. When properly applied to wet the tool and workpiece, minimum quality lubrication reduces the build up edge on a cutting tool and increases the tool life up to 100 times compared to dry micromilling of 316L and stainless steel. Keywords: cutting fluidmicromanufacturingmicromillingminimum quantity lubricationstainless steeltool life ACKNOWLEDGMENT This material is based upon work supported by the National Science Foundation under Grant No. 0552885. Additional support from Haas Automation, Unist, and MA Ford are greatly appreciated.
Guess Your Neighbor’s Input: A Multipartite Nonlocal Game with No Quantum Advantage (2010)

We present a multipartite nonlocal game in which each player must guess the input received by his neighbor. We show that quantum correlations do not perform better than classical ones at this game, for any prior distribution of the inputs. There exist, however, input distributions for which general no-signaling correlations can outperform classical and quantum correlations. Some of the Bell inequalities associated with our construction correspond to facets of the local polytope. Thus our multipartite game identifies parts of the boundary between quantum and postquantum correlations of maximal dimension. These results suggest that quantum correlations might obey a generalization of the usual no-signaling conditions in a multipartite setting.
Effect of switching field gradient for thermally assisted magnetic recording (2007)

The effects of the switching field gradient and the optimal head-field intensity for thermally assisted magnetic recording were investigated using the Landau-Lifshitz-Gilbert equation, which adds a stochastic thermal field to an effective field. The switching field gradient was defined as the product of a space gradient of temperature dT∕dx and a temperature gradient of anisotropy field dHk∕dT under condition of the uniform head-field intensity. The signal-to-noise ratio at 1000kfci was found to improve with increasing dT∕dx and by applying the optimal dHk∕dT.
Zur Chemie von Polyhalocyclopentadienen (1956)

Herstellung und Reaktionen einiger 1.2.3.4-Tetrahalo-cyclopentadiene-(1.3) werden beschrieben.
Transactivation-dependent and -independent Regulation of p73 Stability (2005)

The tumor suppressor p53 regulates its own stability by transcriptionally activating Mdm2, Pirh2, and COP1, which target p53 for degradation. However, whether such a negative feedback mechanism exists to regulate the stability of p73, the structural and functional homologue of p53, is unclear. Unlike p53, p73 is not mutated in cancers, but its expression is significantly elevated. Thus, we have investigated the regulation of p73 turnover. Our data suggest the existence of a negative feedback mechanism for p73 degradation. p73 mutants with compromised transactivation activity are generally more stable than the full-length TAp73 form. TAp73 appears to promote its own turnover as well as that of other p73 forms, including the DeltaNp73 that lacks the amino-terminal transactivation domain, in a transactivation-dependent manner. This degradation-inducing property of TAp73 was inhibited only by p73 mutants that also inhibit the transactivation activity TAp73 but not by mutant p53, highlighting the specificity in the regulation of p73 stability. Moreover, regions in the amino and carboxyl termini of p73 confer both stabilizing and destabilizing effects on the protein, independent of its transactivation ability. Finally, we have identified the regions between amino acids 56 and 248 of p73 as being the region required for p73-mediated and for ubiquitin-mediated degradation. Taken together, the data suggest that p73 turnover is tightly regulated in a transactivation-dependent and -independent manner, resulting in the controlled expression of the various p73 forms.
Dry ozonation of amines. Conversion of primary amines to nitro compounds (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDry ozonation of amines. Conversion of primary amines to nitro compoundsEhud Keinan and Yehuda MazurCite this: J. Org. Chem. 1977, 42, 5, 844–847Publication Date (Print):March 1, 1977Publication History Published online1 May 2002Published inissue 1 March 1977https://pubs.acs.org/doi/10.1021/jo00425a017https://doi.org/10.1021/jo00425a017research-articleACS PublicationsRequest reuse permissionsArticle Views755Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design For all case study: A navigation aid for elderly persons (2014)

This study presents a body worn laser device as an appropriate navigation aid for the people suffering from dementia. The study is based on award-winning “Smart Navigation for Seniour Citizen” concept that was presented at Design For All Foundation 2012 International competition. The wearable mobile system which consists of a camera and a laser pointer is a chest worn device equipped with laser projection-based arrows to guide the people suffering from dementia in indoor/outdoor mobility. This device is able to provide navigation aid to the people suffering from dementia in complex and unknown areas; it also helps the user to identify the real objects. A remote caregiver can easily get the scene where the demented person seeing and can guide the directions with laser projected arrows and directly pointing at the real objects with a laser pointer. In this paper we will explain the usability of chest-worn system in indoor/outdoor environments. The results of an indoor field test conducted with real end users are presented. Results reveal the validity and effectiveness of the chest-worn system in the complex and unknown areas.
Photo-induced travelling waves in condensed Langmuir monolayers (2003)

We report the detailed properties of photo-induced travelling waves in liquid crystalline Langmuir monolayers composed of azobenzene derivatives. When the monolayer, in which the constituent rodlike molecules are coherently tilted from the layer normal, is weakly illuminated to undergo the trans-cis photo-isomerization, spatio-temporal periodic oscillations of the molecular azimuth begin over the entire excited area and propagate as a two-dimensional orientational wave. The wave formation takes place only when the film is formed at an asymmetric interface with broken up-down symmetry and when the chromophores are continuously excited near the long-wavelength edge of absorption to induce repeated photo-isomerizations between the trans and cis forms. Under proper illumination conditions, Langmuir monolayers composed of a wide variety of azobenzene derivatives have been confirmed to exhibit similar travelling waves with velocity proportional to the excitation power irrespective of the degree of amphiphilicity. The dynamics can be qualitatively explained by the modified reaction-diffusion model proposed by Reigada, Sagués and Mikhailov.
IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice (2017)

Nutrition during the perinatal period programs body growth. Growth hormone (GH) secretion from the pituitary regulates body growth and is controlled by Growth Hormone Releasing Hormone (GHRH) neurons located in the arcuate nucleus of the hypothalamus. We observed that dietary restriction during the early postnatal period (i.e. lactation) in mice influences postnatal growth by permanently altering the development of the somatotropic axis in the pituitary gland. This alteration may be due to a lack of GHRH signaling during this critical developmental period. Indeed, underfed pups showed decreased insulin-like growth factor I (IGF-I) plasma levels, which are associated with lower innervation of the median eminence by GHRH axons at 10 days of age relative to normally fed pups. IGF-I preferentially stimulated axon elongation of GHRH neurons in in vitro arcuate explant cultures from 7 day-old normally fed pups. This IGF-I stimulating effect was selective since other arcuate neurons visualized concomitantly by neurofilament labeling, or AgRP immunochemistry, did not significantly respond to IGF-I stimulation. Moreover, GHRH neurons in explants from age-matched underfed pups lost the capacity to respond to IGF-I stimulation. Molecular analyses indicated that nutritional restriction was associated with impaired activation of AKT. These results highlight a role for IGF-I in axon elongation that appears to be cell selective and participates in the complex cellular mechanisms that link underfeeding during the early postnatal period with programming of the growth trajectory.
Color Transparency Effects in Exclusive (e,e'p) Reactions (1995)

Abstract The status of theoretical and experimental researches on color transparency is reviewed. The role of Fermi motion is emphasized as being of crucial importance for the onset of color transparency. Possible exclusive experiments, such as (e,e′p) and (e,e′N∗), are discussed under suitable kinematic conditions which could enhance color transparency effects.
Electric pulse shape impact on biological effects: A modeling study (2015)

Electric pulses (EPs) can permeabilize cell membranes and intracellular organelles through pore formation. Changing the pulse duration and the shape of the pulses can alter the biological effects. Here, simulation results based upon the coupling of the asymptotic Smoluchowski equation for pore formation and the Nernst-Planck equation for ion motion show that a single 10ns or 600 ns EP permeabilizes the cell membrane on the side of field exposure to facilitate electrophoresis of calcium ions into the cell. Following the EP, the pores partially reseal and calcium concentration initially declines before increasing again across the cell due to diffusion. Calcium concentrations increase to ∼5 mM due after approximately 1 ms. Preliminary simulations for other pulse durations and discussed and extensions for bipolar pulses and novel pulse shapes are discussed.
Characterization of cell-binding properties of bovine herpesvirus 1 glycoproteins B, C, and D: identification of a dual cell-binding function of gB (1995)

Previous studies have suggested that the attachment of bovine herpesvirus 1 (BHV-1) to permissive cells is mediated by its major glycoproteins B (gB), C (gC), and D (gD). In order to gain further insight into the mechanism of the BHV-1 attachment process, we purified authentic gB, gC, and gD from BHV-1-infected cells and membrane anchor-truncated, soluble gB, gC, and gD from stably transfected cell lines by affinity chromatography and examined their cell-binding properties on Madin-Darby bovine kidney cells. All of the glycoproteins tested exhibited saturable binding to Madin-Darby bovine kidney cells. All of the glycoproteins tested exhibited saturable binding to Madin-Darby bovine kidney cells. Addition of exogenous heparin or treatment of cells with heparinase to remove cellular heparan sulfate (HS) prevented both gC and gB from binding to cells but had no effect on gD binding. An assessment of competition between gB, gC, and gD for cell binding revealed that gC was able to inhibit gB binding, whereas other combinations showed no effect. Cell-bound gC could be dissociated by heparin or heparinase treatment. The response of bound gB to heparin and heparinase treatments differed for the authentic and soluble forms; while soluble gB was susceptible to the treatment, a significant portion of cell-bound authentic gB was resistant to the treatment. Binding affinity analysis showed that soluble gB and both forms of gC and gD each had single binding kinetics with comparable dissociation constants (Kds), ranging from 1.5 x 10(-7) to 5.1 x 10(-7) M, whereas authentic gB exhibited dual binding kinetics with Kd1 = 5.2 x 10(-7) M and Kd2 = 4.1 x 10(-9) M. These results demonstrate that BHV-1 gC binds only to cellular HS, gD binds to a non-HS component, and gB initially binds to HS and then binds with high affinity to a non-HS receptor. Furthermore, we found that while authentic gB was able to inhibit viral plaque formation, soluble gB, which retains the HS-binding property but lacks the high-affinity binding property, was defective in this respect. These results suggest that the interaction between gB and its high-affinity receptor may play a critical role in the virus entry process.
Utilization of Slaughterhouse Waste in Value-Added Applications: Recent Advances in the Development of Wood Adhesives (2018)

Globally, slaughterhouses generate large volumes of animal byproducts. While these byproducts are an important resource of industrial protein that could potentially be utilized in various value-added applications, they are currently either underutilized in high-value applications or being used for production of relatively low-value products such as animal feed and pet food. Furthermore, some of the byproducts of animal slaughtering cannot enter food and feed chains and thus their disposal possesses a serious environmental concern. An innovative utilization of the proteinaceous waste generated by slaughterhouses comprises of waste processing to extract proteins, which are then incorporated into industrial processes to produce value-added bio-based products. In this report, we review the current processes for extraction of protein from proteinaceous waste of slaughterhouses, and utilization of the recovered protein in the development of protein-based wood adhesives.
Assessment of copper and zinc status of farm horses and training thoroughbreds in south‐east Queensland (1988)

The copper and zinc concentrations in the blood of stabled thoroughbred horses and in Australian Stock Horses mares at pasture, either late pregnant or lactating were determined by an atomic absorption spectroscopic method. The plasma concentration of the trace elements in these apparently normal horses were generally below the "normal" range. The plasma copper, caeruloplasmin copper, whole blood copper and plasma zinc concentrations in the stabled thoroughbreds were 0.76 +/- 0.19 micrograms/ml (n = 82), 0.56 +/- 0.14 micrograms/ml (n = 83), 0.75 +/- 0.18 micrograms/ml (n = 82) and 0.47 +/- 0.09 micrograms/ml (n = 83) respectively. The plasma copper and zinc concentrations of all the brood mares at pasture (pregnant and lactating) were 0.56 +/- 0.20 micrograms/ml and 0.47 +/- 0.11 micrograms/ml (n = 30). The plasma copper concentration of the pregnant group of mares (0.64 +/- 0.18 micrograms/ml; (n = 14) was greater than that of the lactating mares (0.49 +/- 0.21; (n = 16). Variation in the plasma copper concentration was also identified between stabled and farm horses, between horses of different stables and between horses of different ages. The proportion of plasma copper bound to caeruloplasmin was 73 +/- 11.8%. These low concentrations of copper and zinc in the plasma of apparently normal horses are of clinical significance since recent evidence has indicated that copper deficiency appears to promote the development of skeletal abnormalities in foals. An alternative to the use of a single plasma sample to identify the copper or zinc deficient horse was discussed.
Mathematical models of applied biology of some metabolic processes (2003)

Te mathematical model of metabolic processes in growing pigs developed by C.T. Whitmore (1983) is proved to represent an input-output discreet control system with fairly complicated control and state space constraints. We suggest some whose solutions may provide useful information on the feeding policies aiming at prescribed targets.
Enantioselective Synthesis of Both the Enantiomers of Jasmine Ketolactone and Its Epimer (1999)

The enantioselective synthesis of jasmine ketolactone 1, which was isolated as a component of Italian jasmine oil, and its epimer 2 is described. Lactones 1 and 2 were synthesized in 5 and 4 steps, respectively, by Yamaguchi’s macrolactonization method from alcohol 4.
Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red. (1999)

Substantial genetic and biochemical evidence implicates amyloid peptides (Abeta) in the etiology of Alzheimer's Disease (AD). Recent evidence indicates that Abeta1-42 is the predominant species in the hallmark senile amyloid plaque of AD. Furthermore, Abeta1-42 forms aggregates inside lysosomes of cultured neurons leading to lysosomal disruption and cell death. We report here that Abeta1-42 forms slightly cation selective, voltage-independent ion channels with multiple conductance levels at neurotoxic concentrations in planar bilayer membranes. The channels show substantial irregularity of activity, and the size of conductances and the length of open lifetimes depend on solvent history. Formation of channels requires anionic lipids, is enhanced in acidic solutions, and is inhibited by Congo Red. These properties suggest that the channels are formed by aggregates of Abeta1-42. In addition, the channels are reversibly blocked by zinc in a voltage-independent manner. The properties of these channels would likely render them neurotoxic to relevant neurons in vivo. These results are consistent with the channel hypothesis of Abeta neurotoxicity.