gebhart/patrepeval huggingface dataset:
Mutational and transcriptomic landscapes in hematopoietic cells of Fanconi anemia patients (2019)

Fanconi anemia (FA) is a rare genetic disease caused by deficient DNA damage repair. Patients are at risk to develop bone marrow failure (BMF) and secondary myelodysplastic syndrome (MDS) and MDS-related acute myeloid leukemia (MDR-AML). In this project, we aim at understanding the mechanisms of hematopoietic failure and identifying driver mutations and dysregulated pathways involved in progression to MDS/AML. For this, we collected bone marrow samples from FA patients suffering from the different disease stages (i.e. BMF, low-grade MDS, advanced MDS and AML) and subjected them to WES and RNAseq. Preliminary transcriptome data revealed downregulation of DNA repair pathways and upregulation of pro-apoptotic genes in BMF samples. During disease progression towards MDS/AML, mutations in oncogenes and tumor suppressors accumulated. Our work will contribute to a greater understanding of the role of mutations and their deregulated gene expression in the advancement of FA-associated MDR-AML.
Proposal for Beam Extraction from a Modified Betatron Accelerator Using a Toroidal Electric Field (1995)

A technique is proposed for extracting the beam from the modified betatron accelerator. Briefly, after the acceleration is completed, the beam is forced to drift vertically by applying a rapidly rising toroidal electric field. Following the crossing of the septum, the beam enters the extractor, which is either helical or straight. In the latter case the electrons are guided to target by a plasma lens.
Cage structure of fullerene (C60) observed by field ion microscopy (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCage structure of fullerene (C60) observed by field ion microscopyN. Ohmae, M. Tagawa, and M. UmenoCite this: J. Phys. Chem. 1993, 97, 44, 11366–11367Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/j100146a002https://doi.org/10.1021/j100146a002research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Localization of anti-personnel land mines using computationally modeled data for bistatic ground-coupled ground penetrating radar (2013)

Anti-personnel land mines are typically buried below a rough surface where the effectiveness of conventional air-coupled GPR is compromised. This work proposes that antennas be integrated onto the feet of a non-articulated walking robotic platform, in order to achieve ground-contact and thereby improve signal penetration, reduce rough ground clutter, and simplify data analysis. Using three antennas in both the transmitting and receiving modes, three unique bistatic GPR traces can be obtained, from which a target can be detected and localized geometrically using the known antenna locations and the full-path travel times. Using a 3-dimensional finite-difference time domain (FDTD) model, GPR signals are simulated for sixteen statistically different rough surfaces, and both metallic and non-metallic target casings. The soil modeled is both lossy and dispersive. Ultimately, this work demonstrates a detection and localization rate of 100%, independent of surface parameters and target casing, when a target is centered below the robotic platform.
Positron Emission Tomographic Evaluation of Cerebral Blood Flow During State Anxiety in Simple Phobia (1989)

The present study was undertaken to clarify some of the conflicting findings of previous reports on the effect of state anxiety on cerebral blood flow (CBF). Seven subjects with simple phobia of small animals were studied to permit the generation of wide ranges of anxiety. Each subject received five positron emission tomography (PET) scans in a rest-fear-rest-fear-rest, repeated-measures paradigm. A population of eight normal controls was employed. The phobic stimuli produced significant increases in state anxiety during fear and significant differences in physiologic measurements between the fear and rest scans. Absolute global and regional CBF was significantly lower during fear scans than during rest scans; however, when hypocapnia resulting from anxiety-induced hyperventilation was taken into account, the pattern vanished, and all global and regional CBF differences among scans became not significant. Resting global and regional CBF values in the phobic subjects did not significantly differ from those of the normal controls. That a relationship between anxiety and CBF was not found in 35 scans among seven subjects strongly suggests that CBF changes induced by state anxiety are either not presently measurable by PET techniques or that such a relationship may not exist. These findings should also reduce concerns that subject anxiety may confound CBF measurements during routine PET scanning.
Emerging Immunotherapy Options for bacillus Calmette-Guérin Unresponsive Nonmuscle Invasive Bladder Cancer (2019)

There is a clear biological and clinical rationale for the continued evaluation of immune based therapies in the setting of bacillus Calmette-Guérin unresponsive nonmuscle invasive bladder cancer. Data from early phase trials with novel immunotherapies targeting multiple immune related pathways have emerged, which support additional studies to assess the benefits of immune checkpoint inhibitors and other immunotherapy based regimens for patients with bacillus Calmette-Guérin unresponsive nonmuscle invasive bladder cancer.
On the feasibility of blind equalization for EDGE systems (2002)

The main goal of this paper is to find whether or not blind equalization can be used in EDGE (enhanced data rate for GSM evolution) systems in the perspective of increasing the data rate. An EDGE system uses 8-PSK modulation as well as the binary GMSK modulation defined for GSM. The main problem is that GMSK modulation is nonlinear, but most blind equalization techniques are derived for linear modulation. Linear approximation of the real GMSK signal has to be performed in order to apply blind equalization. It is of interest to determine if the input sequence resulting from linearisation and the derotation in the receiver is white, which is a key assumption in many blind equalization algorithms. We show that the whiteness property is preserved. We make a comparison among three blind algorithms: two fractionally spaced and one based on baud-rate HOS. The simulation results indicate that blind equalization performs well and the algorithms have potential as a feasible solution to channel tracking in EDGE systems.
Deletion of the Candida albicans histidine kinase gene CHK1 improves recognition by phagocytes through an increased exposure of cell wall β-1,3-glucans (2010)

The pathogenic fungus Candida albicans is able to cover its most potent proinflammatory cell wall molecules, the β-glucans, underneath a dense mannan layer, so that the pathogen becomes partly invisible for immune cells such as phagocytes. As the C. albicans histidine kinases Chk1p, Cos1p and CaSln1p had been reported to be involved in virulence and cell wall biosynthesis, we investigated whether deletion of the respective genes influences the activity of phagocytes against C. albicans. We found that among all histidine kinase genes, CHK1 plays a prominent role in phagocyte activation. Uptake of the deletion mutant Δchk1 as well as the acidification of Δchk1-carrying phagosomes was significantly increased compared with the parental strain. These improved activities could be correlated with an enhanced accessibility of the mutant β-1,3-glucans for immunolabelling. In addition, any inhibition of β-1,3-glucan-mediated phagocytosis resulted in a reduced uptake of Δchk1, while ingestion of the parental strain was hardly affected. Moreover, deletion of CHK1 caused an enhanced release of interleukins 6 and 10, indicating a stronger activation of the β-1,3-glucan receptor dectin-1. In conclusion, the Chk1p protein is likely to be involved in masking β-1,3-glucans from immune recognition. As there are no homologues of fungal histidine kinases in mammals, Chk1p has to be considered as a promising target for new antifungal agents.
Erratum: Observation of Measurement-Induced Entanglement and Quantum Trajectories of Remote Superconducting Qubits [Phys. Rev. Lett.<b>112</b>, 170501 (2014)] (2015)

00;00 11;11 p (page 3, left column, second paragraph) should read C 2 max0; j 01;10 j -ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi 00;00 11;11 p . No analysis or results are affected by this typographical error.
Supracoronary aortic replacement for acute type A aortic dissection: A risk-factor for developing a late aortic root aneurysm? (2013)

Objective: The study aim was to detect the long-term durability of supracoronary aortic replacement for root aneurysm in patients with acute type A aortic dissection (ATAAD).
Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach (2015)

Traumatic brain injury (TBI) is a growing public health problem worldwide and is a leading cause of death and disability. The causes of TBI include motor vehicle accidents, which are the most common cause, falls, acts of violence, sports-related head traumas, and war accidents including blast-related brain injuries. Recently, pituitary dysfunction has also been described in boxers and kickboxers. Neuroendocrine dysfunction due to TBI was described for the first time in 1918. Only case reports and small case series were reported until 2000, but since then pituitary function in TBI victims has been investigated in more detail. The frequency of hypopituitarism after TBI varies widely among different studies (15-50% of the patients with TBI in most studies). The estimates of persistent hypopituitarism decrease to 12% if repeated testing is applied. GH is the most common hormone lost after TBI, followed by ACTH, gonadotropins (FSH and LH), and TSH. The underlying mechanisms responsible for pituitary dysfunction after TBI are not entirely clear; however, recent studies have shown that genetic predisposition and autoimmunity may have a role. Hypopituitarism after TBI may have a negative impact on the pace or degree of functional recovery and cognition. What is not clear is whether treatment of hypopituitarism has a beneficial effect on specific function. In this review, the current data related to anterior pituitary dysfunction after TBI in adult patients are updated, and guidelines for the diagnosis, follow-up strategies, and therapeutic approaches are reported.
Skin Hypersensitivity to Parainfluenza-3 Virus in Cattle (2010)

Summary Skin hypersensitivity to parainfluenza — 3 virus in cattle 2. Induction by vaccination and specificity Cattle immunized with parainfluenza 3-virus (PIV-3) showed after intracutaneous injection of PIV-3 virus antigen a skin reaction of the delayed type. Young calves with maternal antibodies against PIV-3 did not react to the skin test. These animals did react positively, however, if they had been previously vaccinated intranasally with a living attenuated PIV-3 strain. Cattle actively immunized with PIV-3 did not react to the skin test with parainfluenza-1-virus or with cell extracts as antigen. Zusammenfassung überempfindlichkeit der Haut für das Parainfluenza-3-Virus beim Rind II. Induzierung durch Vakzinierung und Spezifität Rinder, die mit Parainfluenza 3-Virus (PIV-3) immunisiert worden waren, zeigten nach intrakutaner Injektion von Parainfluenza 3-Antigen eine Hautreaktion vom Spättyp. Junge Kälber mit maternalen Antikörpern gegen das PIV-3 reagierten auf die Kutanprobe nicht. Diese Tiere reagierten jedoch positiv, falls man sie vorher mit einem lebenden, attenuierten PIV-3-Stamm intranasal vakziniert hatte. Rinder, aktiv immunisiert mit dem PIV-3, reagierten nicht auf die Kutanprobe mit dem Parainfluenza-l-Virus oder einem Zellextrakt als Antigen. Résumé Supersensibilité cutanée au virus de parainfluenza-3 chez des bovines II. Induction par vaccination et specificité Les bovins activement immunisés contre le virus de Parainfluenza-3 (PIV-3) ont montré une hypersensibilité cutanée à l'injection intradermique d'une préparation d'antigènes au PIV-3. La réaction cutanée est du type retardée. De jeunes veaux avec des anticorps maternels au PIV-3 n'ont pas réagi au test cutané, mais ils ont réagi apres une vaccination nasale avec des souches vivantes mais atténuées de PIV-3. Les bovins activement immunisés contre le PIV-3 n'ont pas montré d'hypersensibilité cutanée lorsque le virus de parainfluenza-1 ou des extraits de cellules ont été utilisés comme antigènes. Resumen Hipersensibilidad cutánea contra el virus de la parainfluenza-3 en bovinos II. Inducción por vacunación y especificidad Bovinos activamente inmunizados con parainfluenza-3 virus (PIV-3) demostraron una reacción de hipersensibilidad cutánea después de la inyección intracutánea de un antígeno de PIV-3. La reaccicón cutánea fué de tipo retardado. Terneros muy jóvenes con anticuerpos maternales contra PIV-3 no reaccionaron, pero lo hicieron así despues de una vacunación intranasal con una cepa atenuada de PIV-3. Bovinos activamente inmunizados con PIV-3 no mostraron reacción cutánea cuando se utilizó un antígeno de parainfluenza-1 o un extracto celular como control.
A SCANNING EQUALIZATION SYSTEM FOR CHEST RADIOGRAPHY (1981)

The common chest radiograph offers a severe challenge to any conventional film screen imaging system due to the wide variations in patient attenuation that exists over the image. Typically the film is exposed to deliver maximum contrast to the lung field with a resultant underexposure in the mediastinum, retrocardiac and diaphragmatic areas. Efforts to improve the uniformity of film exposure have involved specially designed flattening filters, optical masking techniques, double cassettes and the use of 350 kVp x-ray sources. All of these techniques result in images with more uniform exposure but, suffer from several practical limitations including filter registration, increased procedure time and reduced soft tissue contrast and bone detail in the case of high kilovoltage radiography. In this work we will outline a special scanning system used to automatically equalize chest films using a beam of x-rays of about 4 x 4 cm scanned over the patient's chest in a raster fashion to expose conventional film cassette. The beam intensity is measured by a detector placed behind the cassette to give a measure of the patient transmission over the area of the beam. This transmission measurement is used to modify the x-ray tube output so as to properly expose the film at each point and by this means maintain optimal exposure over the entire film. We have constructed a prototype chest scanner capable of performing one full scan in, five seconds making approximately 1500 attenuation measurements over the entire chest film. We will review the imaging characteristics of this type of system, and review, some preliminary results.
Synthesis of 5‐Aryltriazole Ribonucleosides via Suzuki Coupling and Promoted by Microwave Irradiation. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ChemInform Abstract: First Synthesis of the Enantiomerically Pure α‐Hydroxy Analogue ( III) of S‐tert‐Butyl Cysteine. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MacroSS (2010)

SIMD (Single Instruction, Multiple Data) engines are an essential part of the processors in various computing markets, from servers to the embedded domain. Although SIMD-enabled architectures have the capability of boosting the performance of many application domains by exploiting data-level parallelism, it is very challenging for compilers and also programmers to identify and transform parts of a program that will benefit from a particular SIMD engine. The focus of this paper is on the problem of SIMDization for the growing application domain of streaming. Streaming applications are an ideal solution for targeting multi-core architectures, such as shared/distributed memory systems, tiled architectures, and single-core systems. Since these architectures, in most cases, provide SIMD acceleration units as well, it is highly beneficial to generate SIMD code from streaming programs. Specifically, we introduce MacroSS, which is capable of performing macro-SIMDization on high-level streaming graphs. Macro-SIMDization uses high-level information such as execution rates of actors and communication patterns between them to transform the graph structure, vectorize actors of a streaming program, and generate intermediate code. We also propose low-overhead architectural modifications that accelerate shuffling of data elements between the scalar and vectorized parts of a streaming program. Our experiments show that MacroSS is capable of generating code that, on average, outperforms scalar code compiled with the current state-of-art auto-vectorizing compilers by 54%. Using the low-overhead data shuffling hardware, performance is improved by an additional 8% with less than 1% area overhead.
THEORY OF DOUBLE-QUANTUM COHERENCE AND HIGH RESOLUTION DEUTERIUM NMR IN SOLIDS (1976)

When a spin-I with quadrupole interaction wQ is.irradiated near resonance Wo (wo-W = 6w) with an rf field wI such that wI W Q the density matrix essentially evolves in a three dimensional frame of reference defined '.'..
The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease (2015)

Diabetes is a risk factor for Alzheimer disease (AD). Apolipoprotein E (ApoE) and several genes related to AD have recently been identified by genome-wide association studies (GWAS) as being closely linked to lipid metabolism. Lipid metabolism and glucose-energy metabolism are closely related. Here, we review the emerging evidence regarding the roles of lipid and glucose metabolism in the modulation of β-amyloid, tau, and neurodegeneration during the pathogenesis of AD. Disruption of homeostasis of lipid and glucose metabolism affects production and clearance of β-amyloid and tau phosphorylation, and induces neurodegeneration. A more integrated understanding of the interactions among lipid, glucose, and protein metabolism is required to elucidate the pathogenesis of AD and to develop next-generation therapeutic options.
The Value of GPC3 and GP73 in Clinical Diagnosis of Hepatocellular Carcinoma (2017)

The expression of serum GPC3 and GP73 was significantly higher in the HCC patients compared with the cirrhosis patients. GPC3 and GP73 might be effective non-invasive diagnostic indicators of HCC.
Metadata for smart multimedia learning objects (2000)

The application of educational metadata is nowadays often limited to the description of static resources (text or image) in order to support the retrieval process. The usage of metadata is done in a static way with respect to the (static) content and cannot influence multimedia content itself. An adequate description of dynamic multimedia content, for example animations, is also difficult.In this paper we propose dynamic educational metadata as an extension of IEEE's Learning Objects Metadata (LOM) to describe multimedia content. These metadata can be used to customize the behavior of the multimedia object according to the user's needs. The term customization is normally used in the context of component software technology and applied in our context to denote changes and/or modifications to a multimedia learning object. These changes are necessary to match the learning goals of a user and to reuse dynamic multimedia content in a different context.
The Surgical Intensive Care Unit as a Cost-Efficient Substitute for an Operating Room at a Level I Trauma Center (1999)

Critically ill patients in the surgical intensive care unit (SICU) continue to require operative procedures. Traditionally, this has meant the transport of these critically ill patients out of the safe, monitored confines of the SICU to the operating room (OR). This can be hazardous to the patient, as well as expensive. Performing the procedures in the OR can avoid both the dangers of transport and the expense of the OR. Herein is a descriptive study of 80 procedures performed on 36 patients in the SICU. We believe that these data show that the SICU can be a cost-effective alternative to the OR in a trauma center in critically ill patients. Significant cost savings may be realized without increasing the iatrogenic or infectious complications.
Monte Carlo Simulations in Acousto-Photonic Imaging (2002)

Acousto-Photonic imaging (API) is a new technique for non-invasive medical imaging combining diffusive optical tomography (DOT) and focused ultrasound. Monte Carlo simulations are presented for the interaction of Near-Infrared light (NIR) and ultrasound in dense turbid media with high albedo.
Digitized optical microscopy with extended depth of field (1989)

Partial information about a 3-D object, such as a stereoscopic pair of projections, is sometimes more desirable than the whole 3-D information. We demonstrate how to (1) synthesize a clear projection of a small complex object from a succession of digitized images obtained by moving the object stepwise through the focal plane, (2) synthesize a clear projection of a selected layer of a biological specimen composed of multiple curved layers, and (3) measure precisely the 3-D surface of a small object.
Neuregulin 1 Improves Glucose Tolerance in db/db Mice (2015)

In vitro experiments using rodent skeletal muscle cells suggest that neuregulin 1 (NRG1) is involved in glucose metabolism regulation, although no study has evaluated the role of NRG1 in systemic glucose homeostasis. The purpose of this study was to investigate the effect of chronic and acute NRG1 treatment on glucose homeostasis in db/db mice. To this aim, glucose tolerance tests were performed in 8-week-old male db/db mice after treatment with NRG1 (50μg.kg-1) or saline 3 times per week for 8 weeks. In other experiments, glucose tolerance and pyruvate tolerance tests were performed in db/db mice 15 minutes after a single NRG1 (50μg.kg-1) or saline injection. Liver, adipose tissue, hypothalamus and skeletal muscle were also collected 30 minutes after acute NRG1 (50μg.kg-1) or saline treatment, and the phosphorylation status of the ERBB receptors, AKT (on Ser473) and FOXO1 (on Ser256) was assessed by western blotting. Chronic treatment (8 weeks) with NRG1 improved glucose tolerance in db/db mice. Acute treatment also lowered glycemia and insulinemia during glucose or pyruvate tolerance tests. NRG1 acute injection induced activation of ERBB3 receptors and phosphorylation of AKT and FOXO1 only in liver. Altogether, this study shows that acute and chronic NRG1 treatments improve glucose tolerance in db/db mice. This effect could be mediated through inhibition of hepatic gluconeogenesis.