gebhart/patrepeval huggingface dataset:
OXIDATIVE PHOSPHORYLATION BY PYRIDOXINEDEFICIENT RAT BRAIN MITOCHONDRIA<sup>1,</sup><sup>2</sup> (1972)

Abstract— Oxygen uptake, ADP/O ratios and respiratory control ratios (RCR) were studied by the oxygen electrode technique in mitochondria prepared from adult and neonatal brains from normal and pyridoxine‐deficient rats. The mitochondria from neonatal brain exhibited decreased rates of substrate oxidation, ADP/O ratios and respiratory control ratios in comparison to those obtained with mitochondria from the respective adult brains. The cytochrome contents of the neonatal brains were also less than those of the adults. Within the neonatal or adult groups, there were no differences in any of the parameters tested between the normal and pyridoxine‐deficient rats.
Finite-size effects in thin-film composites (2002)

Abstract Many formulations of the mechanical response of thin-film composites consider the film layers to extend to infinity in the surface plane of the composite. These layers are also assumed to be much thinner than the substrate. Under these assumptions the stress in the substrate becomes negligibly small and the stress transfer between layers does not depend on the elastic moduli of the interfaces. Consequently, in most studies of blanket thin films these terms have received little attention. For thin-film composites with finite dimensions, these terms may be important and they can be calculated from the traditional shear lag model and its extensions. In this paper we show that these models provide widely divergent results when applied to the same structure. These differences arise from the initial stress state and geometry assumptions implicitly contained in such models. Comparison with experimental observations shows that further work is required before these models can be applied to patterned thin-film structures.
709: Ureterolysis: A Comparison of Laparoscopic Versus open Approach (2007)

You have accessJournal of UrologyModerated Poster 21, Monday, May 21, 2007, 8:00 - 10:00 am1 Apr 2007709: Ureterolysis: A Comparison of Laparoscopic Versus open Approach Arun K. Srinivasan, Lee Richstone, Sompol Permpongkosol, and Louis R. Kavoussi Arun K. SrinivasanArun K. Srinivasan More articles by this author , Lee RichstoneLee Richstone More articles by this author , Sompol PermpongkosolSompol Permpongkosol More articles by this author , and Louis R. KavoussiLouis R. Kavoussi More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30949-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "709: Ureterolysis: A Comparison of Laparoscopic Versus open Approach." The Journal of Urology, 177(4S), p. 238 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 238 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Arun K. Srinivasan More articles by this author Lee Richstone More articles by this author Sompol Permpongkosol More articles by this author Louis R. Kavoussi More articles by this author Expand All Advertisement PDF downloadLoading ...
The application of the energy landscape model to polymers (1999)

The energy landscape model of the glass transition has received increasing attention, due to its potential for providing a thermodynamic interpretation of the dynamics of glass-forming liquids. Herein, the idea that the temperature-dependence of the dynamics near the glass temperature (“fragility”) can be related to thermodynamic properties is tested for polymers. Previously, for several homologous series, we found deviations from a proposed correlation between fragility and the heat capacity increment at the glass temperature. A survey of 17 polymers likewise indicates no correlation between these two quantities. More recently, the landscape approach to the dynamics of glass-formers was extended to a proposal that fragility can be determined a priori from thermodynamic information. However, for the 11 polymers for which sufficient thermodynamic and relaxation data were available, we find that thermodynamic properties bear no relationship to fragility. Thus, it appears that the status of the glass transition as an important unsolved problem in condensed matter physics remains intact.
BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure. (1981)

The transplantable murine B-cell leukemia, BCL1, was examined by light and electron microscopy. The results show that the BCL1 cell closely resembles the prolymphocyte of human prolymphocytic leukemia (PLL). The spleen of animals transplanted with BCL1 is diffusely infiltrated by BCL1-prolymphocytes. Splenectomized animals given transplants of BCL1 develop a lymphomalike disease with less leukemia and bone marrow involvement than the nonsplenectomized transplant recipients. Ultrastructural features of the BCL1 cell are identical in the splenectomized and nonsplenectomized animals.
Deep sequencing of the chimpanzee transcriptome identifies numerous novel transcribed regions in frontal cortex and liver (2010)

We have performed the first global profiling of the chimpanzee transcriptome by using deep sequencing of cDNA from brain and liver. This enabled us to quantify expression of RefSeq transcripts, ide ...
SOME NOVEL REACTIONS OF 4-QUINAZOLONE<sup>1,2</sup> (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSOME NOVEL REACTIONS OF 4-QUINAZOLONE1,2NELSON J. LEONARD and DAVID Y. CURTINCite this: J. Org. Chem. 1946, 11, 4, 341–348Publication Date (Print):July 1, 1946Publication History Published online1 May 2002Published inissue 1 July 1946https://pubs.acs.org/doi/10.1021/jo01174a006https://doi.org/10.1021/jo01174a006research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recent Research Activities on Laser-plasma Particle Accelerators for Opening up their Applications (2009)

Laser-plasma particle accelerators (LPA) can make accessible, in a compact setup, the science and applications that are presently limited to large-scale accelerator facilities. Research efforts have been concentrated on stabilization of LPAs since the development of monoenergetic electron bunches. By adopting new techniques such as an artificial injection of electrons, plasma channel for guiding laser pulses, and magnetization of plasmas, the stability of LPAs can be improved considerably. Recently several approaches have been employed for opening up the applications of LPAs, for example, generation of femtosecond electron bunches, use of tunable ultrashort X-rays, and use of proton injectors for synchrotrons.
Altered drug binding due to the use of indwelling heparinized cannulas (heparin lock) for sampling (1979)

The effect of the use of the so-called heparin lock for blood sampling on the binding of propranolol has been studied and a cumulative dose-response curve to heparin constructed. The use of this method of blood sampling introduced considerable artifactual changes into the measurement of propranolol's plasma binding. The free fraction rose from 9.9% to 13.4% after only 50 U of heparin was used to flush the cannula. The increase in the free fraction of propranolol showed excellent correlation with the increase in free fatty acid levels (p less than 0.001, r = 0.996). The importance of ensuring that sampling techniques do not introduce artifactual changes in pharmacokinetic studies is emphasized.
Laser Guiding of Electron Beams in the Advanced Test Acceleration (1986)

The recently demonstrated technique of laser guiding has been used to propagate successfully a 10-kA relativistic electron beam 95 m through the Advanced Test Accelerator and postaccelerator beamline. The maximum transverse displacement of the beam at the end of the Advanced Test Accelerator was 1 mm while the maximum beam breakup amplitude was 0.1 mm. The use of laser guiding constitutes a breakthrough in accelerator technology in that it is able to reduce greatly or even suppress the beam breakup instability, which is the most serious obstacle to high-current beam transport in linear induction accelerators.
Regio- and Chemoselective Addition of Mixed Copper, Zinc Benzylic Organometallics to Functionalized Pyridinium Salts: A Facile Synthesis of Functionalized 4-Benzylpyridines (1991)

2′,3-Disubstituted 4-benzylpyridines 4 were synthesized in good yield by reaction of mixed copper, zinc benzylic organometallics 1 with 3-substituted 1-(ethoxycarbonyl)pyridinium chlorides 2 followed by sulfur oxidation under reflux in decalin.
Application of packet control method for a high power high voltage flyback converter to reduce noise influence (2005)

In the regulated switching power supplies, the output voltage is usually sampled across a resistive voltage divider. In high voltage applications, the resistance of the voltage divider is very high in order to reduce its power loss. Therefore, these resistors are very good receivers of environment noise. This paper introduces a new control method for a high power, high voltage flyback converter insensitive to the noise caused by ringing due to the leakage reactance of a high voltage flyback converter. In this method, output voltage is sampled in an intentionally extended cycle to be sure that all the oscillations are damped. Therefore there is no need to additional damping circuits and snubbers network and the efficiency of converter is not reduced. This method is applicable to any flyback converter in discontinues conduction mode. Mathematical concept is introduced and simulation and experimental results are presented
Glucosinolates in Sisymbrium officinale (L.) Scop.: Comparative Analysis in Cultivated and Wild Plants and in Vitro Assays with T2Rs Bitter Taste Receptors (2019)

<i>Sisymbrium officinale</i> (L.) Scop., commonly known as "hedge mustard" or "the singer's plant" is a wild plant common in Eurasian regions. Its cultivation is mainly dedicated to herboristic applications and it has only recently been introduced into Italy. The active botanicals in <i>S. officinale</i> are glucosinolates, generally estimated by using UV or high-performance liquid chromatography (HPLC). Using both techniques, we measured the total glucosinolates from <i>S. officinale</i> in different parts of the plant as roots, leaves, seeds, and flowers. A comparison was made for cultivated and wild samples, and for samples obtained with different pre-treatment and fresh, frozen, and dried storage conditions. Cultivated and wild plants have a comparable amount of total glucosinolates, while drying procedures can reduce the final glucosinolates content. The content in glucoputranjivin, which is the chemical marker for glucosinolates in <i>S. officinale</i>, has been determined using HPLC and a pure reference standard. Glucoputranjivin and two isothiocyanates from <i>S. officinale</i> have been submitted to in vitro assays with the platform of bitter taste receptors of the T2Rs family. The results show that glucoputranjivin is a selective agonist of receptor T2R16.
Phycoerythrins of marine unicellular cyanobacteria. III. Sequence of a class II phycoerythrin (1991)

The genes for the alpha and beta subunits of a novel six bilin-bearing (class II) phycoerythrin were cloned from Synechococcus sp. WH8020 and sequenced. The cloned genes (mpeA and mpeB) were detected by homology with the genes for C-phycoerythrin from Pseudanabaena sp. PCC7409. The mpe locus occurs once in the genome and is arranged similarly to that of many other phycobiliproteins, with mpeA shortly 3' of mpeB. Sequence comparison suggests that this phycoerythrin (and perhaps all class II phycoerythrins) occupy a branch of the phycoerythrin family separate from five-chromophore per alpha beta (class I) phycoerythrins, C-phycoerythrin, and B-phycoerythrin. The position of the sixth chromophore of the class II phycoerythrin of WH8020 was determined by comparison of the amino acid sequence of the chromopeptides (Ong, L. J., and Glazer, A. N. (1991) J. Biol Chem. 266, 9515-9527) with the sequence deduced from the gene. This located the chromophore at residue 75 of the alpha subunit, very close to the alpha-83 chromophore in the primary structure and, presumably, in the three-dimensional structure.
N-Arachidylanthranilic Acid, a New Derivative from Ononis natrix (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Arachidylanthranilic Acid, a New Derivative from Ononis natrixSuleiman Al-Khalil, Amneh Masalmeh, Shtaywy Abdalla, Hideki Tosa, and Munekazu IinumaCite this: J. Nat. Prod. 1995, 58, 5, 760–763Publication Date (Print):May 1, 1995Publication History Published online1 July 2004Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/np50119a018https://doi.org/10.1021/np50119a018research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanical Thrombectomy in Hemodialysis Access Shunts Using a 5F Pigtail Rotation Catheter (1999)

In our experimental setup as well as under clinical conditions, effective treatment of occluded hemodialysis access sites was achieved. The pigtail rotation device is an easy-to-handle, inexpensive alternative to mechanical thrombus fragmentation in occluded hemodialysis access shunts. The rate of emboli in the effluent vein of approximately one third of the initial thrombus weight must be taken into consideration in frequent intraindividual use of this technique.
Failure Mode, Effects and Criticality Analysis (FMECA) for Medical Devices: Does Standardization Foster Improvements in the Practice? (2015)

Risk analysis techniques received increasing attention in the health care sector in the last 30 years. These techniques are diffused for health care processes, and less for devices. In fact, risk management for medical devices was introduced only recently (ISO 14971 in 2000 and GHTF/SG3/N15R8 in 2005) [1,2]. The goal of this study is twofold. First, we aim at evaluating the state of the art of the diffusion of standards for the risk assessment of medical devices (with a focus on FMECA). Second, we evaluate the impact of risk assessment techniques on the practice. To pursue the first goal, a literature review has been performed through the investigation of medical and non-medical databases. To reach the second objective, we selected a leading Company in the development of medical devices and we investigated the process enacted to evaluate the risk connected to the design of new devices. The literature search confirmed the widespread application of the FMECA, the scant number of contributions about its applications on medical devices, and the main limitations related to the use of this technique. The empirical investigation showed that the Company spends a surprising amount of time and resources to set and deploy the FMEA rigorously, and it follows the passages envisioned by the literature carefully, with the unique intent to respect the standards. A gap emerges among the practitioners and academic words, with two possible explanations. First, the academics are not addressing the managerial and practical implications of their contributions; in so doing they deepen the “theory versus practice” chasm. Second, the presence of standards actually discourages the practitioners to push over and find new solutions.
Simulation and Measurement Results of Complex Integrated Vehicle Antenna Systems for Premium Audio Reception (2001)

<div class="htmlview paragraph">This paper presents the achievements in vehicle antenna system simulation and measurement. Highlights of the applied Method of Moments will be described, as well as needed steps towards an accurate vehicle antenna simulation will be shown. Simulation assessment with correspondence to an antenna test vehicle measured in a highly sophisticated vehicle antenna measurement range will be described. The measurement range, test setup, the antennas with an example of an integrated, multiple glass-antenna-system for FM-diversity reception and the results are provided. With these advanced antenna simulation methods, significant progress in vehicle antenna simulation is achieved which allows virtual prototype development steps in vehicle antenna design. Simulated and measured results will also be given provided for SDARS.</div>
Evaluation of pharmacokinetics, bioavailability and dose linearity of diltiazem in healthy volunteers. (1993)

The objective of this randomized five-way cross-over study with healthy male volunteers was to determine, one the one hand, the bioavailability and main pharmacokinetic parameters of 4 sustained release diltiazem (Surecaps, CAS 42399-41-7) test preparations with ascending doses (180, 240, 300, 360 mg), administered as single application, versus an immediate release 60 mg diltiazem reference preparation, which was given thrice a day at 8-h intervals. On the other hand, the study also allowed the evaluation of a possible dose linearity of the test substance diltiazem. Plasma concentrations of diltiazem and its major metabolite desacetyl-diltiazem were measured by high pressure liquid chromatography (HPLC) up to 48 h after single dosing of the sustained release preparations as well as after repeated doses of the immediate release formulation. The undesired side effects/concomitant symptoms observed are known to occur after diltiazem administration. For the area under the curve, e.g. calculated from time 0 to the last quantifiable sample (AUC0-Tlast), the study revealed for the parent compound diltiazem mean values of 926.2, 1602.4, 1873.2 and 2415.7 h.ng/ml after administration of the 4 sustained release test preparations, respectively; for the immediate release reference preparation the value was 1007.2 h.ng/ml. Concerning the main metabolite desacetyl-diltiazem the corresponding values for the 4 sustained release formulations were 138.6, 236.9, 280.2 and 345.6 h.ng/ml, respectively. The corresponding value for the immediately release formulation was 127.5 h.ng/ml. Concerning a possible dose linearity of diltiazem, statistical analysis revealed a convincing linear relationship between at least 3 of the 4 sustained release preparations, therefore linearity may be assumed between 240 and 360 mg.(ABSTRACT TRUNCATED AT 250 WORDS)
THE PATHOLOGY OF ACUTE DISSEMINATED ENCEPHALOMYELITIS PRODUCED EXPERIMENTALLY IN THE RHESUS MONKEY AND ITS RESEMBLANCE TO HUMAN DEMYELINATING DISEASE (1947)

Journal Article The Pathology of Acute Disseminated Encephalomyelitis Produced Experimentally in the Rhesus Monkey and Its Resemblance to Human Demyelinating Disease Get access Abner Wolf, M.D., Abner Wolf, M.D. New York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Elvin A. Kabat, Ph.D., Elvin A. Kabat, Ph.D. New York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ada E. Bezer Ada E. Bezer New York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Neuropathology & Experimental Neurology, Volume 6, Issue 4, October 1947, Pages 333–357, https://doi.org/10.1097/00005072-194710000-00003 Published: 01 October 1947
Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells (2010)

Oncolytic viruses that selectively infect and lyse cancer cells have potential as therapeutic agents. Myxoma virus, a poxvirus that is known to be pathogenic only in rabbits, has not been reported to infect normal tissues in humans or mice. We observed that when recombinant virus was injected directly into the lateral ventricle of the mouse brain, virally encoded red fluorescent protein was expressed in ependymal and subventricular cells. Cells were positive for nestin, a marker of neural stem cells. Rapamycin increased the number of cells expressing the virally encoded protein. However, protein expression was transient. Cells expressing the virally encoded protein did not undergo apoptosis and the ependymal lining remained intact. Myxoma virus appears to be safe when injected into the brain despite the transient expression of virally derived protein in a small population of periventricular cells.
Retroviral nucleocapsid domains mediate the specific recognition of genomic viral RNAs by chimeric Gag polyproteins during RNA packaging in vivo (1995)

The retroviral nucleocapsid (NC) protein is necessary for the specific encapsidation of the viral genomic RNA by the assembling virion. However, it is unclear whether NC contains the determinants for the specific recognition of the viral RNA or instead contributes nonspecific RNA contacts to strengthen a specific contact made elsewhere in the Gag polyprotein. To discriminate between these two possibilities, we have swapped the NC domains of the human immunodeficiency virus type 1 (HIV-1) and Moloney murine leukemia virus (M-MuLV), generating an HIV-1 mutant containing the M-MuLV NC domain and an M-MuLV mutant containing the HIV-1 NC domain. These mutants, as well as several others, were characterized for their abilities to encapsidate HIV-1, M-MuLV, and nonviral RNAs and to preferentially package genomic viral RNAs over spliced viral RNAs. We found that the M-MuLV NC domain mediates the specific packaging of RNAs containing the M-MuLV psi packaging element, while the HIV-1 NC domain confers an ability to package the unspliced HIV-1 RNA over spliced HIV-1 RNAs. In addition, we found that the HIV-1 mutant containing the M-MuLV NC domain exhibited a 20-fold greater ability than wild-type HIV-1 to package a nonviral RNA. These results help confirm the notion that the NC domain specifically recognizes the retroviral genomic RNA during RNA encapsidation.