gebhart/patrepeval huggingface dataset:
Abstract 2536: Therapeutic testing of a novel PKC inhibitor GAP-107B8 on ovarian cancer cells (2010)

Abstract Background: Ovarian cancer is the most fatal gynaecologic disease in the western world. In 2009 in North America, an estimated 23,896 women will develop ovarian cancer and an estimated 15,24050 women will die from this disease. Current treatments are limited to surgery or chemotherapy, but the disease often recurs. Thus, the development of novel cancer therapeutics remains important. The protein kinase C (PKC) family of serine/threonine kinases is involved in cellular proliferation, differentiation, apoptosis and cell polarity. One PKC isoform, PKC iota, has recently been identified as a human oncogene and has been shown to be overexpressed in serous epithelial ovarian cancers and is thus a potential therapeutic target for ovarian cancer. Objective: We have tested a novel PKC inhibitor GAP-107B8 (PharmaGap Inc., Ottawa) in vitro on a panel of nine ovarian cancer cell lines to determine its potential to inhibit cell proliferation, proliferation in soft agar, and migration. Methods: Nine ovarian cancer cell lines were treated with three different concentrations of GAP-107B8 and then screened using high throughput assays to measure the proliferation of cells in adherent and anchorage independent (soft agar) cultures. The ability of cells to migrate in the presence of GAP-107B8 was also determined. Results: We observed significant reduction in cell proliferation in 6 of 9 ovarian cancer cell lines tested, including two cell lines resistant to the standard chemotherapy. GAP-107B8 inhibited cell proliferation by 30% to 79% compared with untreated cells, with more than 50% inhibition in 4 of 7 cell lines. Treatment with GAP-107B caused a reduction in growth in soft agar in 7 of the 9 cell lines tested in vitro. GAP-107B8 inhibited growth in soft agar by 50% to 94% compared with untreated cells, with 80% or greater inhibition in 6 of 7 cell lines. Finally, 5 of 8 cell lines tested showed significant inhibition of mobility following treatment with GAP-107B8. There was 50% or greater inhibition in all 5 cell lines compared with untreated cells. Conclusion: The novel PKC inhibitor GAP-107B8 displays good efficacy in vitro in suppressing several cancer cell characteristics in a variety of ovarian cancer cell lines. Further experiments are underway to investigate the therapeutic potential of GAP-107B8 in xenograft models of ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2536.
Ceramic transactions: Advances in ceramic-matrix composites III. Volume 74 (1994)

Ceramic-matrix composites are strong, tough, environmentally stable, light in weight, and have the ability to withstand high operating temperatures. This makes them viable candidate materials for high-temperature structural applications. The purpose of this symposium was to provide an international forum for scientists, engineers, and technologists to discuss and exchange ideas on state-of-the-art ceramic-matrix composites. Fifty-five papers describing the latest developments in the areas of fibers, interfaces, processing and fabrication, mechanical behavior, in situ and nano-composites, oxide and nonoxide composites, glass and glass-ceramic composites, particulate- and whisker-reinforced composites, metal-ceramic systems, environmental effects, characterization and test methods including N.D.E., etc. are included in this volume. Separate abstracts have been indexed into the database for contributions to this proceedings.
PHENOTYPING AND GENOTYPING OF RUBUS GERMPLASM FOR THE IMPROVEMENT OF QUALITY TRAITS IN THE RASPBERRY BREEDING PROGRAM (2012)

A phenotypic-genotypic characterization of more than 250 Rubus accessions was achieved in Northern Italy (Trentino) over multiple years, both for varietal comparison and for the improvement of the breeding programme. The key traits investigated were related to morphological, flowering and horticultural aspects. Tolerance to the main pests and diseases, such as two-spotted spider mite (Tetranychus urticae Koch) and Resseliella theobaldi (Raspberry Cane Midge - RCM), and diversity profiles were also assessed. Genetic diversity among the accessions evaluated was confirmed by a significant variability for several components involved in fruit quality, post-harvest performance, biotic and abiotic stress tolerance. Phenotyping of raspberry allowed us also to select interesting primocane advanced selections, and to define parental lines of great importance to the FEM breeding program, both for fresh and processing markets use. Genotyping was subsequently integrated with phenotypic information through the use of Single Nucleotide Polymorphisms (SNP) markers for high-throughput screening for a dual benefit: in order to drive more efficiently the targeted traits and to guarantee cultivar protection.
Overreaching in coordination dynamics therapy in an athlete with a spinal cord injury. (2008)

A motocross athlete suffered a clinically complete spinal cord injury (SCI) during competition. Although MRIs (magnetic resonance imaging) showed a complete spinal cord injury at the Thoracic 11/12 levels, surface EMG recordings indicated the survival of few tract fibres across the injury site. Six weeks after the accident the subject began intensive Coordination Dynamics Therapy (CDT) at an up-to-date therapy centre. The subject trained at his physical limits to induce structural and functional repair. Exercising at variable loads between 20 and 200N (on a special CDT and recording device) generated periods of overreaching and super-compensation. By plotting coordination dynamics values (kinesiology), including high-load exertion (200N) and hysteresis curves, periods of overreaching and super-compensation were made graphically visible. It was found that symmetrical improvements of central nervous system (CNS) functioning occurred during overreaching. Improvements in spinal cord functioning were achieved throughout one year of CDT in this chronically injured subject with an almost anatomically complete SCI. It is discussed that the measuring of CNS functions by means of recording coordination dynamics is a powerful and non-invasive tool ideal for exact quantitative and qualitative measurements of improvement (or change) in CNS functioning. Such diagnostics may be of particular importance in sport during training and before competition. Also, coordination dynamics might be used to measure the effects of prolonged exposure to reduced gravitational conditions on CNS functions, such as faced by astronauts.
Preparation of Boc‐[S‐(3‐nitro‐2‐pyridinesulfenyl)]‐cysteine and its use for unsymmetrical disulfide bond formation (1986)

The 3-nitro-2-pyridinesulfenyl (Npys) derivative of cysteine was prepared and used to facilitate the formation of an unsymmetrical disulfide bond. Since this derivative is stable in trifluoroacetic acid:CH2 Cl2 (1:1) and anhydrous hydrogen fluoride, Boc-Cys(Npys) could be used directly in solid phase synthesis of the 14-peptide acetyl-Cys(Npys)-Gly-Glu-Gln-Gln-His-His-Pro-Gly-Gly-Gly-Ala-Lys-G ln-Ala-amide. Reaction of this peptide with the free thiol of another peptide, acetyl-Gly-Glu-Gln-His-His-Pro-Gly-Gly-Gly-Ala-Lys-Gln-Cys-amide, gave a single product containing an unsymmetrical disulfide bond. The amino acid composition of this product and HPLC analysis of its dithiothreitol reduction products were consistent with the desired heterodimer. As evidenced by HPLC, the mixed disulfide forms rapidly at alkaline pH and usefully over a wide pH range in aqueous buffers.
HEMOPHAGOCYTIC SYNDROME IN PREGNANCY (2000)

In Brief Background Hemophagocytic syndrome is characterized by nonmalignant histiocytes that undergo uncontrolled phagocytosis of normal hematopoietic cells. Clinical severity ranges from complete recovery to rapid deterioration and death. Case Thrombocytopenia was discovered upon routine initial prenatal evaluation of a 24-year-old, gravida 2, para 1, at 29 weeks' gestation with a history of necrotizing lymphadenitis. Cytopenia and elevated transaminases developed, followed by hyperpyrexia. The patient delivered and her postpartum course was complicated by coagulopathy, multiorgan failure, and death. Bone marrow biopsy confirmed hemophagocytic syndrome. Conclusion Early diagnosis of hemophagocytic syndrome during pregnancy might be helped by recognizing symptoms and signs, including a history of necrotizing lymphadenitis, and obtaining a bone marrow biopsy. Hemophagocytic syndrome during pregnancy can cause rapid deterioration and death.
" Parallel-coupled Stub-loaded Resonators Compact Size Tunable Filter " (2010)

International audience
Studying the Influence of Salts on Partitioning of Proteins: Isoelectric Point Determination (2003)

In addition to its application as a separation process, aqueous two-phase partitioning often yields information on important physical properties of proteins, replacing other more cumbersome analytical techniques. For example, aqueous two-phase partitioning can be used to measure the hydrophobicity and charge of a protein (1-3), to calculate dissociation constants between enzymes and substrates (4), to fractionate cell populations (5), or to characterize cell surfaces (6,7).
Observation and modelling of HO <sub>x</sub> radicals in a boreal forest (2013)

Abstract. Measurements of OH and HO2 radicals were conducted in a~pine dominated forest in Southern Finland during the HUMPPA-COPEC-2010 (Hyytiälä United Measurements of Photochemistry and Particles in Air – Comprehensive Organic Precursor Emission and Concentration study) field campaign in summer 2010. Simultaneous side-by-side measurements of hydroxyl radicals were conducted with two instruments using chemical ionization mass spectrometry (CIMS) and laser-induced fluorescence (LIF), indicating good agreement. Subsequently, the LIF instrument was moved to the top of a 20 m tower, just above the canopy, to investigate the radical chemistry at the ecosystem–atmosphere interface. Comprehensive measurements including observations of many VOCs and the total OH reactivity were conducted and analysed using steady-state calculations as well as an observationally constrained box model. Production rates of OH calculated from measured OH precursors are consistent with those derived from the steady state assumption and measured total OH loss under conditions of moderate OH reactivity. The primary photolytic sources of OH contribute up to one third to the total OH production. OH recycling, which occurs mainly by HO2 reacting with NO and O3, dominates the total hydroxyl radical production in this boreal forest. Box model simulations agree with measurements for hydroxyl radicals (OHmod./OHobs. = 1.04 ± 0.16), while HO2 mixing ratios are significantly underpredicted (HO2mod./HO2obs. = 0.3 ± 0.2) and simulated OH reactivity does not match the observed OH reactivity. The simultaneous underprediction of HO2 and OH reactivity in periods in which OH concentrations were simulated well, suggests that the missing OH reactivity is an unaccounted source of HO2. Detailed analysis of the HOx production, loss, and recycling pathways suggests that in periods of high total OH reactivity there are additional recycling processes forming OH directly, not via reaction of HO2 with NO or O3. Nevertheless, a major fraction of the OH recycling occurs via the reaction of HO2 with NO and O3 in this terpene dominated environment.
23.2: The Visibility of a Color Gradient Across the Screen for Stimuli Presented Time‐Sequentially or Simultaneously (2002)

Abstract The visibility threshold of a color gradient across the screen is determined for the specific application of mobile displays. The color gradient was implemented as a change in saturation or in hue from the center of the screen towards the edges in horizontal direction. Its visibility threshold is determined in a double‐stimulus subjective test. To investigate the influence of the way stimuli are presented in this type of tests, each pair of stimuli is shown twice to the subjects: once with the two stimuli of the pair simultaneously, and once with the two stimuli of the pair time‐sequentially. The results exhibit a remarkable difference in the effect of the way stimuli are presented between the visibility in a saturation gradient and in a hue gradient.
Ecologia e dinâmica populacional de Biomphalaria tenagophila (Orbigny, 1835) (Mollusca, Gastropoda) em cultura de agrião (Nasturtium officinale) no Alto da Boa Vista, Rio de Janeiro (1991)

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Left-sided appendicitis with reversed internal organs (1969)

Left-sided appendicitis is an extremely rare pathology in urgent surgery. It occurs with dystopia of the large intestine and with the reverse complete arrangement of internal organs. 4019 appendectomies performed from 1964 to 1967 in the emergency department of the 12th mountains. hospitals in Kazan, left-sided appendicitis met only once. Here is our observation.
The No Endosonographic Detection of Tumor (NEST) Study: a Case Series of Pancreatic Cancers Missed on Endoscopic Ultrasonography (2004)

EUS is not a foolproof method of detecting a pancreatic neoplasm. Possible associated factors that may increase the likelihood of a false-negative EUS examination include chronic pancreatitis, a diffusely infiltrating carcinoma, a prominent ventral/dorsal split and a recent episode (< 4 weeks) of acute pancreatitis. If there is a high clinical suspicion of pancreatic neoplasm, if EUS and other imaging methods are negative, and if the patient does not undergo surgery, this study suggests that a repeat EUS after 2-3 months may be useful for detecting an occult pancreatic neoplasm.
The Aluminocenium Cation [Al(C<sub>5</sub>H<sub>5</sub>)<sub>2</sub>]<sup>+</sup>: A Highly Effective Initiator for the Cationic Polymerization of Isobutene (1996)

One of the last hitherto unknown simple metallocenes, the aluminocenium cation [Al(η-C5H5)2]+ 1, is readily accessible from [AlCp2Me] and B(C6F5)3. The spectroscopic data are consistent with a metallocene structure. The complex is a highly efficient initiator for the carbocationic polymerization of isobutene and the industrially important copolymerization of isobutene and isoprene.
Capacitance and Conductance of Single-Walled Carbon Nanotubes in the Presence of Chemical Vapors (2005)

Simultaneous conductance and capacitance measurements on a single-walled carbon nanotube (SWNT) network are used to extract an intrinsic property of molecular adsorbates. Adsorbates from dilute chemical vapors produce a rapid response in both the capacitance and the conductance of the SWNT network. These responses are caused by a combination of two distinct physiochemical properties of the adsorbates: charge transfer and polarizability. We find that the ratio of the conductance response to the capacitance response is a concentration-independent intrinsic property of a chemical vapor that can assist in its identification.
OPC rectification of random space patterns in 193-nm lithography (2002)

This paper presents a methodology for modeling the space printability at the gate level in 193nm lithography. Spaces are shown to be more susceptible to process variations and lens aberrations than lines are. Experimental Scanning Electron Microscopy (SEM) pictures show that the scum and bridging effects can occur in spaces although all the line critical dimensions (CDs) are on target. A resist imaging model is used to simulate the line CDs through defocus, pitch and size, and the prediction error is within 5nm. However, this model can not reasonably predict space CDs without using variable threshold, which is explained a proposed trajectory dissolution rate model. Based on the dissolution model, a process rule checker is proposed which inspects the peak light intensity in a space and compares it with a given threshold. This condition is verified experimentally.
Effect of Organic Acid Additions on the General and Localized Corrosion Susceptibility of Alloy 22 in Chloride Solutions (2008)

Abstract Electrochemical studies using cyclic potentiodynamic polarization (CPP) and electrochemical impedance spectroscopy (EIS) were performed to determine the corrosion behavior of Alloy 22 (N06022) in 1M NaCl solutions at various pH values from acidic to neutral at 90°C. All the tested material was wrought Mill Annealed (MA). Tests were also performed in NaCl solutions containing weak organic acids such as oxalic, acetic, citric and picric acids. Results show that the corrosion rate of Alloy 22 was significantly higher in solutions containing oxalic acid than in solutions of pure NaCl at the same pH. Citric and Picric acids showed a slightly higher corrosion rate, and Acetic acid maintained the corrosion rate of pure chloride solutions at the same pH. Organic acids revealed to be weak inhibitors for crevice corrosion. Higher concentration ratios, compared to nitrate ions, were needed to completely inhibit crevice corrosion in chloride solutions. Results are discussed considering acid dissociation constants, buffer capacity and complex formation constants of the different weak acids.
Chronic graft-versus-host disease: a breakdown of self-tolerance? (2005)

Comment on Tivol et al, page [4885][1] 

The immunologic response to foreign alloantigens in graft-versus-host disease can lead to the breakdown of self-tolerance precipitating autoimmunity. 

G raft-versus-host disease (GVHD) is a major life-threatening complication of allogeneic bone marrow
Polarographic Determination of Sulfite (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarographic Determination of SulfiteD. B. Aulenbach and J. L. BalmatCite this: Anal. Chem. 1955, 27, 4, 562–564Publication Date (Print):April 1, 1955Publication History Published online1 May 2002Published inissue 1 April 1955https://pubs.acs.org/doi/10.1021/ac60100a021https://doi.org/10.1021/ac60100a021research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis on the CTLM and LTLM applicability for GaN HEMTs structure alloyed ohmic contact resistance evaluation (2013)

In this letter, we have demonstrated that the circular transmission linear model (Marlow's CTLM) is unsuitable for GaN HEMTs structure alloyed ohmic contact resistance evaluation. Very large spread is found in the extracted ohmic resistance values from measured data using the commonly used CTLM test patterns, and some of the contact resistances are found to be negative. We suspect that the stress induced by ohmic contact formation process is the culprit, preventing the use of CTLM test pattern for GaN HEMTs structure ohmic contact resistance evaluation, because of the strong piezoelectric induced polarization property of the hexagonal III-nitride heteroj unction device structure. Meanwhile, measured ohmic contact resistance (R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> ) and sheet resistance (R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sq</inf> ) are found to exhibit good uniformity using a properly prepared linear transmission line model (LTLM) test pattern in which all the Gallium nitride material extended beyond the gaps between the ohmic contact electrodes are removed.
Quadratic programming algorithms for obstacle problems (1996)

The numerical solution of problems involving frictionless contact between an elastic body and a rigid obstacle is considered. The elastic body may undergo small or large deformation. Finite element discretization and repetitive linearization lead to a sequence of quadratic programming (QP) problems for incremental displacement. The performances of several QP algorithms, including two new versions of a modified steepest descent algorithm, are compared in this context. Numerical examples include a string, a membrane and an Euler-Bernoulli beam, in contact with flat and non-flat rigid obstacles.
Backpressure-based routing protocol for DTNs (2010)

In this paper we consider an alternative, highly agile In this paper we consider an alternative, highly agile approach called backpressure routing for Delay Tolerant Networks (DTN), in which routing and forwarding decisions are made on a per-packet basis. Using information about queue backlogs, random walk and data packet scheduling nodes can make packet routing and forwarding decisions without the notion of end-to-end routes. To the best of our knowledge, this is the first ever implementation of dynamic backpressure routing in DTNs. Simulation results show that the proposed approach has advantages in terms of DTN networks.
SU-GG-BRC-01: Modeling Myocardial Mn2+ Efflux Rates Using Manganese-Enhanced MRI T1 Mapping in a Murine Myocardial Infarction Model (2009)

Purpose: Alterations in myocyte handling appear to be centrally involved in the dysfunctional characteristics of the failing heart. This study uses quantitative manganese-enhanced MRI techniques to detect changes in the efflux relative to fluctuations in mice following inhibition of the sodium calcium exchanger (NCX) with SEA0400. Furthermore, the technique was applied to a mouse myocardial infarction (MI) model. Segmentation and modeling analyses were used to examine regional changes in efflux rates, allowing for a study of the dynamics in the peri-infarction zone. Methods and Materials: was infused via the tail vein into C57Bl/6 mice (n=88). T1-maps were obtained both pre- and post-infusion at multiple time points. Time dependent changes in the relaxation rate (ΔR1) were calculated in the myocardium. For the MI mice various affected zones within the myocardium were identified and analyzed using segmentation software. The results from control and SEA0400 treated mice were applied to a pharmacokinetic model in order to estimate the transfer rates. Results: The ΔR1 efflux half-life was doubled following treatment with 50 mg/kg SEA0400, with the two compartment model predicting a reduction in the myocardial efflux rate by more than a factor of two. In the MI group constant ΔR1 values for viable and infarcted tissue were fit with radial analysis. A significant difference was observed between the efflux rates of the infarcted region to that of the viable region, with a continuous range of efflux rates in the peri-infarcted region. Conclusions: Quantitative MEMRI with T1-mapping has demonstrated the sensitivity to observe changes in efflux with the ability to model the relative efflux rates. The technique also provides enough sensitivity for identifying the potentially salvageable adjacent zone as well as examining regional alterations in fluxes leading to relative information, potentially applicable to monitoring disease progression.