gebhart/patrepeval huggingface dataset:
Insulin receptor substrate polymorphisms and Type 2 diabetes mellitus (2000)

Insulin receptor substrate (IRS) molecules are key mediators in insulin signalling and play a central role in maintaining basic cellular functions, such as growth, survival and metabolism. They act as docking proteins for the insulin receptor and a complex network of intracellular signalling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3 and IRS-4) of this family have been identified that differ in tissue distribution, subcellular localisation, developmental expression, binding to the insulin receptor and interaction with SH2 domain-containing proteins. Results from targeted disruption of the IRS genes in mice have provided important clues as to the functional differences among these related molecules and suggest that they play very different roles in vivo. The available data are consistent with the notion that both IRS-1 and IRS-2 are important for insulin action and glucose homeostasis in vivo, whereas IRS-and IRS-4 appear to play a redundant role in the IRS signalling system. Considering their key role in both insulin action and insulin secretion, IRS-1 and IRS-2 molecules have been considered plausible candidate genes involved in the pathogenesis of Type 2 diabetes. Several polymorphisms in the IRS genes have been identified, but only the Gly --> Arg72 substitution of IRS-1, acting with environmental factors, seems to have a pathogenic role in the development of Type 2 diabetes. In contrast, polymorphisms of the other IRS genes do not appear to contribute to Type 2 diabetes.
A memory hierarchy-aware metadata management technique for Solid State Disks (2011)

Solid State Disk (SSD) drives are rapidly replacing conventional hard disk drives (HDDs) due to their remarkable performance gains. For emulating HDDs, SSDs require a flash translation layer (FTL) which hides the out-of-place-update feature of NAND flash memories. In the latest large-capacity SSDs, FTLs must manage huge metadata such as a logical-to-physical address mapping table, a pool of free blocks, or a list of garbage blocks with their erase counts. The total metadata cannot reside on a small on-chip SRAM so that it must be hierarchically distributed in DRAM or NAND flash memories. This paper presents an efficient metadata management technique for SSDs which fully exploits memory hierarchy of an SSD. By the proposed technique, the distributed metadata can be efficiently searched or updated with small overheads. Experimental results show that overheads of metadata management become considerably large in the latest SSDs and they are minimized efficiently by the proposed technique.
Differences in pulse oximetry technology can affect detection of sleep-disorderd breathing in children. (2002)

The Masimo oximeters register many fewer false desaturations due to motion artifact. Using 4-second averaging, a Masimo oximeter detected significantly fewer SaO2 dips than the Nellcor N-200 oximeter but using 2-second averaging, the Masimo oximeter detected more SaO2 dips than the Nellcor N-200 oximeter. The sensitivity and motion artifact rejection characteristics of the Nellcor N-395 oximeter are not adequate for a pediatric sleep laboratory setting. These findings suggest that in a pediatric sleep laboratory, use of a Masimo oximeter with very short averaging time could significantly reduce workload and improve reliability of desaturation detection.
The asparagine-linked oligosaccharides on bovine fetuin. Structural analysis of N-glycanase-released oligosaccharides by 500-megahertz 1H NMR spectroscopy. (1988)

The structures of the entire population of sialylated asparagine-linked oligosaccharides present on bovine fetuin were elucidated. Asparagine-linked oligosaccharides were released from fetuin with N-glycanase, radiolabeled by reduction with NaB[3H]4, and fractionated by anion-exchange high performance liquid chromatography (HPLC), ion-suppression amine adsorption HPLC, and concanavalin A affinity chromatography. The 3H-labeled oligosaccharide fractions obtained were analyzed by 500-MHz 1H nuclear magnetic resonance spectroscopy, revealing the presence of 23 distinct oligosaccharide structures. These oligosaccharides differed in extent of sialylation (3% mono-, 35% di-, 54% tri-, and 8% tetrasialylated), number of peripheral branches (17% di- and 83% tribranched), linkage (alpha 2,3 versus alpha 2,6) and location of sialic acid moieties, and linkage (beta 1,4 versus beta 1,3) of galactose residues. This represents the first time that the asparagine-linked oligosaccharides of fetuin have been successfully fractionated and characterized as sialylated species. The sialylated oligosaccharides derived from fetuin were also used to further define the specificities of the lectins leukoagglutinating phytohemagglutinin and Ricinus communis agglutinin I. The behavior of these oligosaccharides during lectin affinity HPLC further establishes the structural features which predominate in the interaction of oligosaccharides with leukoagglutinating phytohemagglutinin and R. communis agglutinin I.
The optimization of collection of peripheral blood stem cells for autotransplantation in acute myeloid leukaemia. (1989)

Between November 1982 and November 1986 31 patients with acute myeloid leukaemia underwent peripheral blood stem cell apheresis during haemopoietic regeneration following induction chemotherapy. A retrospective analysis of the factors affecting the efficacy of stem cell harvest and of the clinical outcome of these patients was performed. The mean number of myeloid progenitor cells (CFU-GM) collected was significantly higher in the complete remission group (n = 22) than in the partial remission group (n = 9). Fifty x 10(4) CFU-GM/kg body weight or more, which produced rapid, complete and sustained haemopoietic reconstitution after autografting in our patients, were collected from six of nine patients who underwent three or four 7-litre aphereses over 5-7 days using a lymphocyte collection procedure on the Fenwal CS3000 [Protocol B] but only from two of 12 patients who underwent three or four 5-litre aphereses over 3-5 days using the Aminco Celltrifuge [Protocol A] (p less than 0.05). No adverse effects on the rates of neutrophil, platelet and lymphocyte recovery after induction chemotherapy or on long-term disease-free survival for patients who achieved a complete remission could be attributed to apheresis when compared with a historical control group of 39 patients who achieved complete remission following the same induction chemotherapy but did not undergo apheresis. We conclude that sufficient numbers of peripheral blood stem cells to produce safe and rapid haemopoietic reconstitution can be collected from most patients who achieve complete remission using apheresis Protocol B without impairment of haemopoietic recovery or adversely affecting the length of complete remission.
Hepatitis B Virus DNA in Liver and White Blood Cells of Patients with Hepatoma (1983)

Hepatitis B virus (HBV) DNA was studied in liver DNA of 23 patients with primary hepatocellular carcinoma and in white blood cell DNA of 11 of these patients by Southern blot hybridization analysis probed with 32P-labeled HBV DNA cloned in plasmid pBR325. Of the 23 hepatoma DNA samples, 16 were positive for HBV DNA, and 15 of these showed integration of HBV DNA into the host liver DNA. In 5 patients, free HBV DNA was found in addition to integrated HBV DNA and in only one was free HBV found alone. All patients serologically positive for HBV surface antigen (HBsAg) were positive for HBV DNA in tumor samples. The pattern and the degree of hybridization differed considerably among different cases. HBV DNA was found in tumor and in adjacent nontumor tissue in two patients. Of 11 white blood cell DNA samples, two were positive for HBV DNA. The HBV DNA in the white blood cells was not integrated into the host DNA. In the undigested white blood cell DNA, the free HBV DNA gave a positive signal at 5.5 kb and often also at 9.5 kb. After Eco RI digestion, these 5.5-kb and 9.5-kb positive fragments disappeared, while a strong positive band at 3.2-kb appeared. Hind III digestion produced the same positive fragments as in the undigested white blood cell DNA and failed to produce the 3.2-kb fragment. Sometimes, especially after Hind III digestion, a positive fragment at a position corresponding to about 16.2 kb was also demonstrable in addition to the 5.5-kb and 9.5-kb positive fragments.(ABSTRACT TRUNCATED AT 250 WORDS)
The pulmonary physician in critical care 2: Oxygen delivery and consumption in the critically ill (2002)

Early detection and correction of tissue hypoxia is essential if progressive organ dysfunction and death are to be avoided. However, hypoxia in individual tissues or organs caused by disordered regional distribution of oxygen delivery or disruption of the processes of cellular oxygen uptake and utilisation cannot be identified from global measurements. Regional oxygen transport and cellular utilisation have an important role in maintaining tissue function. When tissue hypoxia is recognised, treatment must be aimed at the primary cause. Supplemental oxygen may be life saving in some situations but cannot correct inadequate oxygen delivery caused by a low cardiac output or impaired ventilation. Recent innovations include artificial oxygen carrying proteins and "haemoglobin" molecules designed to improve tissue blood flow by reducing viscosity. Regulating cell metabolism using different substrates or drugs has so far been poorly explored but is an exciting area for further research. A minimum level of global oxygen delivery and perfusion pressure must be maintained in the critically ill patient with established "shock", but advances in the understanding and control of regional distribution and other "downstream" factors in the oxygen cascade are needed to improve outcome in these patients.
[Human CD96 gene cloning, expression and identification]. (2011)

The CD96 gene of human has been successfully cloned and expressed in BL21(DE3) cells, and its rabbit polyclonal antibody has been obtained.
Alignment of Curved Text Strings for Enhanced OCR Readability (2013)

Conventional optical character recognition systems, designed to recognize linearly aligned text, perform poorly on document images that contain multi-oriented text lines. This paper describes a novel technique that can extract text lines of arbitrary curvature and align them horizontally. By invoking the spatial regularity properties of text, adjacent components are grouped together to obtain the text lines present in the image. To align each identified text line, we fit a B-spline curve to the centroids of the constituent characters and normal vectors are computed all along the resulting curve. Each character is then individually rotated such that the corresponding normal vector is aligned with the vertical axis. The method has been tested on images that contain text laid out in various forms namely arc, wave, triangular and combination of these with linearly skewed text lines. It yields 97.3% recognition accuracy on text strings where state-of-the-art OCRs fail before alignment.
IL-33 and Its Receptor ST2 after Inhaled Allergen Challenge in Allergic Asthmatics (2018)

In mild asthmatics, there was a significant upregulation of ST2 surface expression on eosinophils from blood and sputum following allergen inhalation challenge. In vitro, IL-33 stimulation of eosinophils increases both ST2 membrane expression and IL-5 production. These results support a role for IL-33 in causing allergen-induced eosinophilia. Blockade of IL-33 and ST2 signaling may present a novel therapeutic avenue for asthma treatment.
Design and implementation of AMBA ASB APB bridge (2013)

The 32 bit AMBA ASB APB Bridge provides an interface between the Advanced System Bus (ASB) and the Advanced Peripheral Bus (APB). It inserts wait states for burst of read or write transfers when the ASB must wait for the APB. The bridge is designed to respond to transaction requests from the currently enabled ASB master. The ASB transactions are converted into APB transactions. APB peripherals do not need a clock input as the APB access is timed with a strobe signal generated by the ASB to APB bridge interface. The AMBA ASB APB Bridge is modeled using Verilog HDL and validated on SPARTAN 3E and results are visualized on ChipScope Pro.
Use of amine oxide surfactants for chemical flooding EOR (enhanced oil recovery) (1989)

The use of amine oxides with and without alcohols as cosolvents, and in combination with other surfactants as mixed micellar formulations for enhanced oil recovery by surfactant flooding was investigated. Amine oxides are a salt-tolerant class of surfactants that produce low interfacial tension and can develop viscosity without the addition of polymers. These salt-tolerant formulations generate three-phase regions with hydrocarbons over a broad salinity range, develop moderate solubilization, and produce low interfacial tensions, however oil recovery from amine oxide-alcohol phase behavior optimized formulations was directly dependent upon the quantity of surfactant injected. The large pore volume and high concentration of surfactant required prohibits their economic use as the primary surfactant in chemical flooding EOR. Dimethylalkylamine oxides are useful as cosurfactants and viscosifiers in formulations with other surfactants for chemical flooding EOR but the use of ethoxylated and propoxylated amine oxides should be avoided due to the decomposition of these amine oxides under reservoir conditions. Phase behavior, phase inversion temperatures, and viscosity scans have been correlated with surfactant structures to provide a guide for amine oxide applications in chemical flooding. 36 refs., 5 figs., 6 tabs.
Multipath Propagation at 4, 6, and 11 GHz (1972)

Signals at 4, 6, and 11 GHz, transmitted over a 28.5-mile radio relay path in Ohio, were continuously monitored during the late summer of 1966. Previous publications have reported on the observed 4- and 6-GHz multipath fading statistics, and on the improvements available with space or frequency diversity. This paper presents data for the 11-GHz transmission, and, in combination with the earlier results, establishes an empirical frequency dependence for the amplitude statistics. A general treatment of the relationships between the factors underlying multipath propagation is intractable. However, based on the results in this and other papers, a general relationship is given for the probability of deep multipath fading which is linear in frequency, cubic in path length, and varies with meteorological-geographical factors. Temporal aspects of the Ohio data were also investigated at all frequencies, utilizing both a 1-hour and a 1-day clock time interval. It was found that the multipath fade time statistic can be described by a single parameter for either interval. A subset of the multipath fading hours was also analyzed using a 1-minute clock interval, with the result that the difference between the minute median fade and the hourly median fade is frequency independent, and normally distributed with a standard deviation of 5.5 dB.
New all-optical logic gates based on the local nonlinear Mach-Zehnder interferometer (2008)

We propose new all-optical logic gates containing a local nonlinear Mach-Zehnder interferometer waveguide structure. The light-induced index changes in the Mach-Zehnder waveguide structure make the output signal beam propagate through different nonlinear output waveguides. Based on the output signal beam propagating property, various all-optical logic gates by using the local nonlinear Mach-Zehnder waveguide interferometer structure with two straight control waveguides have been proposed to perform XOR/NXOR, AND/NAND, and OR/NOR logic functions.
MWD for shallow water demultiple: a Hibernia case study (2012)

Summary Model-based Water-layer Demultiple (MWD) is a recently-developed method aimed at tackling the challenge of multiple attenuation in shallow water. MWD works by modeling the Green’s function of the water-bottom primary reflections based on a user-supplied water-layer model, then convolving it with the recorded data to predict water-layer-related multiples. In this paper, MWD is applied to Hibernia field data which has a water depth of around 70-90 meters. The results show that while SRME by itself has limited success, MWD is effective in attacking water-layer-related multiples. The effectiveness is attributed to the fact that MWD predicts the multiple models with correct relative amplitude and a spectrum similar to the input data’s. SRME, on the other hand, suffers in shallow-water situations, primarily due to cross-talk between multiples. Once the water-layer-related multiples are removed by MWD, SRME can then be applied to predict and eliminate other types of surface-related multiples which tend to have longer periodicity and less cross-talk. The combination of MWD and SRME is demonstrated as an effective demultiple package for shallow-water data and results in fewer residual multiples and better-preserved primaries over tau-p gapped deconvolution. This, in turn, contributes to a more realistic velocity model and, finally, higher quality images.
A distributional list of Southern California opisthobranchs (1961)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Establishment of Highly Differentiated Immortalized Human Hepatocyte Line With Simian Virus 40 Large Tumor Antigen for Liver Based Cell Therapy (2005)

Acute liver failure and metabolic liver disorder animal models have demonstrated that hepatocytes transplanted into the liver or spleen survive and participate in the liver repopulation process, and recent studies have documented the usefulness of hepatocyte transplantation in humans. However, despite the promising cell therapy, there are still many restrictions, such as the shortage of donor human livers and the limited lifespan and the functional insufficiency of primary cultured hepatocytes. The immortalized and highly differentiated human hepatocyte could provide an unlimited supply of transplantable cells. In this study, we established an efficient and highly differentiated immortalized human hepatocyte line for bioartificial liver and hepatocyte transplantation research. Hepatocytes isolated from the liver of a 25 year old, brain dead male were transfected with pcDNA3.1 (-) recombinant plasmid containing the genes encoding simian virus 40 (SV40) large tumor antigen. One of the hepatocyte clones, HepLL, displayed highly differentiated liver functions with immortalized characteristics and was selected with a 700-300 microg/ml of G418 technique in 42 days. To characterize this immortalized cell line for cell therapy in the near future, HepLL cells were studied with immunohistochemistry, reverse transcription-polymerase chain reactions, immunoblotting, and tumorigenicity tests. The results revealed that HepLL cells displayed morphologic characteristics of liver parenchymal cells, secreted albumin, synthesized urea and glycogen, and expressed liver enriched functional markers, but there were no tumorigenic qualities after transplantation into severe combined immunodeficiency mice. Thus this immortalized human hepatocyte line is expected to be a useful tool for studying the functions of differentiated human hepatocyte and a promising strategy to resolve the shortages of donor organs and the limits of primary human hepatocyte for transplantation and bioartificial liver support systems.
Ultrasound Systems for Biometric Recognition (2019)

Biometric recognition systems are finding applications in more and more civilian fields because they proved to be reliable and accurate. Among the other technologies, ultrasound has the main merit of acquiring 3D images, which allows it to provide more distinctive features and gives it a high resistance to spoof attacks. This work reviews main research activities devoted to the study and development of ultrasound sensors and systems for biometric recognition purposes. Several transducer technologies and different ultrasound techniques have been experimented on for imaging biometric characteristics like fingerprints, hand vein pattern, palmprint, and hand geometry. In the paper, basic concepts on ultrasound imaging techniques and technologies are briefly recalled and, subsequently, research studies are classified according to the kind of technique used for collecting the ultrasound image. Overall, the overview demonstrates that ultrasound may compete with other technologies in the expanding market of biometrics, as the different commercial fingerprint sensors integrated in portable electronic devices like smartphones or tablets demonstrate.
I can see myself enjoying that: Using imagery perspective to circumvent bias in self-perceptions of interest. (2019)

People experience life satisfaction when pursuing activities that genuinely interest them. Unfortunately, cultural stereotypes (e.g., "science is not for girls") and preexisting self-beliefs can bias people's memories, thereby hindering their ability to identify the domains that they actually experience as interesting. The current experiments tested a novel method for circumventing this problem by manipulating visual imagery perspective as people recalled their experiences. Four experiments measured (or manipulated) participants' actual experience of interest as they completed a task; the experiments also measured (or manipulated) participants' self-beliefs about their interest in the domain. The experiments then manipulated imagery perspective as participants recalled their interest in the task. Prior research suggests that imagery from an actor's first-person perspective facilitates a bottom-up processing style, whereas imagery from an external third-person facilitates a top-down processing style (Libby & Eibach, 2011). Consistent with this account, across all 4 experiments, first-person imagery (vs. third-person) caused people's recall to be less biased by the top-down influence of their self-beliefs and better aligned with their past experienced interest. The final experiment demonstrated downstream consequences of these effects on female undergraduates' intentions to pursue future activities in a domain (STEM) that negative stereotypes typically might dissuade them from pursuing. Thus, the present results suggest that first-person imagery can be a useful tool to reduce the influence of biased self-beliefs, while increasing sensitivity to past bottom-up experiences during recall. Further, these results hold practical implications for reducing psychological barriers that can keep underrepresented individuals from pursuing interests in counterstereotypical domains. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Survey on Reliability of Power Electronic Systems (2012)

With wide-spread application of power electronic systems across many different industries, their reliability is being studied extensively. This paper presents a comprehensive review of reliability assessment and improvement of power electronic systems from three levels: 1) metrics and methodologies of reliability assessment of existing system; 2) reliability improvement of existing system by means of algorithmic solutions without change of the hardware; and 3) reliability-oriented design solutions that are based on fault-tolerant operation of the overall systems. The intent of this review is to provide a clear picture of the landscape of reliability research in power electronics. The limitations of the current research have been identified and the direction for future research is suggested.