gebhart/patrepeval huggingface dataset:
Coconut coir dust extract: a novel eco-friendly corrosion inhibitor for Al in HCl solutions (2012)

Abstract Corrosion inhibition of aluminium in 1 M HCl by coconut coir dust extract (CCDE) was studied using weight loss and hydrogen evolution techniques at 30 and 60°C. It was found that the studied extract exhibits a very good performance as inhibitor for aluminium corrosion in 1 M HCl. Results show that the inhibition efficiency increases with increasing temperature and concentration of the extract. Inhibitive effect was afforded by adsorption of the extracts' components which was found to accord with Langmuir adsorption isotherm. Inhibition mechanism is deduced from the temperature dependence of the inhibition efficiency and was further corroborated by the values of activation parameters obtained from the experimental data.
Effective use of multimedia for presentations (2002)

Currently, multimedia technology is widely used for business, education, and entertainment. This paper discusses the design of a multimedia presentation with a system named INTEMOR. The requirements for a multimedia presentation software package include still image and motion video output, sound output, sequential presentation format, nonlinear presentation format (hyperlink), pop-up text and pop-up image display, image map support, portability and CD-ROM support. The implementation of these requirements in INTEMOR is discussed in this paper.
Dynamic PMD Mitigation at 10 Gb/s Using Viterbi Equalization in DPSK Systems (2008)

Compensating dynamically changing polarization-mode dispersion (PMD) is important for optical fiber transmission systems. We present simulations of a Viterbi equalization for dynamic PMD mitigation in 10-Gb/s nonreturn-to-zero differential phase-shift keying systems. The equalizer can dynamically track fast varying differential group delay (DGD) and achieve similar performance to static DGD.
Interleukin-6, nitric oxide, and the clinical and hemodynamic alterations of patients with liver cirrhosis (1999)

Objective: Nitric oxide has been proposed as a mediator of hyperdynamic circulation in cirrhosis. Endotoxin and cytokines induce the synthesis of nitric oxide. The aim of this study was to investigate the relationship between endotoxemia, cytokines, and nitric oxide in patients with cirrhosis, and to correlate these findings with clinical, biochemical, and hemodynamic parameters. Methods: Clinical, biochemical, and hemodynamic parameters were assessed in 66 patients with cirrhosis and 15 controls. Levels of antidiuretic hormone, plasma renin activity, aldosterone, interferon γ, interleukin-1, interleukin-6, tumor necrosis factor α, endotoxin, and nitrates-nitrites were determined. Results: Mean arterial pressure was lower and interleukin-6, tumor necrosis factor α, nitrites-nitrates levels, and endotoxin positivity rates were higher in cirrhotics than in controls (p< 0.005). Mean arterial pressure decreased and interleukin-6 levels increased with worsening of Child score (p< 0.005). Patients with ascites had higher levels of interleukin-6, tumor necrosis factor α, and nitrates-nitrites than patients without ascites (p< 0.01). Elevated levels of interleukin-6 were found in patients with encephalopathy grade I, compared with patients without (p< 0.001); this association was independent of the severity of liver disease. In patients with low mean arterial pressure, interleukin-6 levels were higher than in patients with high mean arterial pressure (p= 0.001), whereas tumor necrosis factor α and nitrates-nitrites levels were not different. By multivariate analysis, high interleukin-6 levels showed independent associations with the presence of ascites, encephalopathy, and low mean arterial pressure. Only interleukin-6 levels had significant correlations with Child score, plasma renin activity, serum and urinary sodium, and mean arterial pressure (r ≥ 0.4,p< 0.005). Conclusions: Although the activity of the nitric oxide pathway is increased in patients with cirrhosis and might contribute to the hemodynamic alteration, other factors are involved. Interleukin-6, possibly through nitric oxide-independent mechanisms, also might play a role in the vasodilatation of cirrhosis and the pathogenesis of hepatic encephalopathy.
Defective Dissociation of a “Slow” RecA Mutant Protein Imparts an Escherichia coli Growth Defect (2008)

The RecA and some related proteins possess a simple motif, called (KR)X(KR), that (in RecA) consists of two lysine residues at positions 248 and 250 at the subunit-subunit interface. This study and previous work implicate this RecA motif in the following: (a) catalyzing ATP hydrolysis in trans,(b) coordinating the ATP hydrolytic cycles of adjacent subunits, (c) governing the rate of ATP hydrolysis, and (d) coupling the ATP hydrolysis to work (in this case DNA strand exchange). The conservative K250R mutation leaves RecA nucleoprotein filament formation largely intact. However, ATP hydrolysis is slowed to less than 15% of the wild-type rate. DNA strand exchange is also slowed commensurate with the rate of ATP hydrolysis. The results reinforce the idea of a tight coupling between ATP hydrolysis and DNA strand exchange. When a plasmid-borne RecA K250R protein is expressed in a cell otherwise lacking RecA protein, the growth of the cells is severely curtailed. The slow growth defect is alleviated in cells lacking RecFOR function, suggesting that the defect reflects loading of RecA at stalled replication forks. Suppressors occur as recA gene alterations, and their properties indicate that limited dissociation by RecA K250R confers the slow growth phenotype. Overall, the results suggest that recombinational DNA repair is a common occurrence in cells. RecA protein plays a sufficiently intimate role in the bacterial cell cycle that its properties can limit the growth rate of a bacterial culture.
Markers of dopamine metabolism in Parkinson's disease (1992)

We used two analytic methods (a multichannel coulometric electrode array with high-performance liquid chromatography, and gas chromatography-mass spectrophotometry) to measure CSF dopamine (DA) and its metabolites in mildly affected, unmedicated subjects with Parkinson's disease (PD). The mean (+/- SD) concentration of homovanillic acid (HVA), the most abundant product of DA turnover, was 164.57 +/- 95.05 nM. As sequential aliquots of CSF were collected from the first to 23rd ml, CSF HVA concentration almost doubled. After HVA, 3-O-methyldopa (3-O-MD) was the next most abundant compound. The summed concentrations of 3-O-MD, 3,4-dihydroxyphenylacetic acid, 3-methoxytyramine, DA, DA-3-sulfate, homovanillol, and levodopa (LD) amounted to 12.6% of HVA. Concentrations of the DA metabolites did not correlate to a variety of indices of PD severity. The presence of LD and 3-O-MD may be indicators of DA synthesis and possibly could reflect compensatory processes among surviving dopaminergic neurons of the PD brain.
Calculating the binding free energies of charged species based on explicit-solvent simulations employing lattice-sum methods: An accurate correction scheme for electrostatic finite-size effects (2013)

The calculation of a protein-ligand binding free energy based on molecular dynamics (MD) simulations generally relies on a thermodynamic cycle in which the ligand is alchemically inserted into the system, both in the solvated protein and free in solution. The corresponding ligand-insertion free energies are typically calculated in nanoscale computational boxes simulated under periodic boundary conditions and considering electrostatic interactions defined by a periodic lattice-sum. This is distinct from the ideal bulk situation of a system of macroscopic size simulated under non-periodic boundary conditions with Coulombic electrostatic interactions. This discrepancy results in finite-size effects, which affect primarily the charging component of the insertion free energy, are dependent on the box size, and can be large when the ligand bears a net charge, especially if the protein is charged as well. This article investigates finite-size effects on calculated charging free energies using as a test case the binding of the ligand 2-amino-5-methylthiazole (net charge +1 e) to a mutant form of yeast cytochrome c peroxidase in water. Considering different charge isoforms of the protein (net charges -5, 0, +3, or +9 e), either in the absence or the presence of neutralizing counter-ions, and sizes of the cubic computational box (edges ranging from 7.42 to 11.02 nm), the potentially large magnitude of finite-size effects on the raw charging free energies (up to 17.1 kJ mol(-1)) is demonstrated. Two correction schemes are then proposed to eliminate these effects, a numerical and an analytical one. Both schemes are based on a continuum-electrostatics analysis and require performing Poisson-Boltzmann (PB) calculations on the protein-ligand system. While the numerical scheme requires PB calculations under both non-periodic and periodic boundary conditions, the latter at the box size considered in the MD simulations, the analytical scheme only requires three non-periodic PB calculations for a given system, its dependence on the box size being analytical. The latter scheme also provides insight into the physical origin of the finite-size effects. These two schemes also encompass a correction for discrete solvent effects that persists even in the limit of infinite box sizes. Application of either scheme essentially eliminates the size dependence of the corrected charging free energies (maximal deviation of 1.5 kJ mol(-1)). Because it is simple to apply, the analytical correction scheme offers a general solution to the problem of finite-size effects in free-energy calculations involving charged solutes, as encountered in calculations concerning, e.g., protein-ligand binding, biomolecular association, residue mutation, pKa and redox potential estimation, substrate transformation, solvation, and solvent-solvent partitioning.
Rate Adaptation and Admission Control for Video Transmission with Subjective Quality Constraints (2013)

Adapting video data rate during streaming can effectively reduce the risk of playback interruptions caused by channel throughput fluctuations. The variations in rate, however, also introduce video quality fluctuations and thus potentially affects viewers' Quality of Experience (QoE). We show how the QoE of video users can be improved by rate adaptation and admission control. We conducted a subjective study wherein we found that viewers' QoE was strongly correlated with the empirical cumulative distribution function (eCDF) of the predicted video quality. Based on this observation, we propose a rate-adaptation algorithm that can incorporate QoE constraints on the empirical cumulative quality distribution per user. We then propose a threshold-based admission control policy to block users whose empirical cumulative quality distribution is not likely to satisfy their QoE constraint. We further devise an online adaptation algorithm to automatically optimize the threshold. Extensive simulation results show that the proposed scheme can reduce network resource consumption by $40\%$ over conventional average-quality maximized rate-adaptation algorithms.
Fate of the herbicides glyphosate, glufosinate‐ammonium, phenmedipham, ethofumesate and metamitron in two Finnish arable soils (2006)

The fate of five herbicides (glyphosate, glufosinate-ammonium, phenmedipham, ethofumesate and metamitron) was studied in two Finnish sugar beet fields for 26 months. Soil types were sandy loam and clay. Two different herbicide-tolerant sugar beet cultivars and three different herbicide application schedules were used. Meteorological data were collected throughout the study and soil properties were thoroughly analysed. An extensive data set of herbicide residue concentrations in soil was collected. Five different soil depths were sampled. The study was carried out using common Finnish agricultural practices and represents typical sugar beet cultivation conditions in Finland. The overall observed order of persistence was ethofumesate > glyphosate > phenmedipham > metamitron > glufosinate-ammonium. Only ethofumesate and glyphosate persisted until the subsequent spring. Seasonal variation in herbicide dissipation was very high and dissipation ceased almost completely during winter. During the 2 year experiment no indication of potential groundwater pollution risk was obtained, but herbicides may cause surface water pollution.
Development in Disaster-prone Places: Studies of Vulnerability [Book Review] (2000)

Includes picture. Publishers details for: Development in Disaster-prone Places: Studies of Vulnerability, By James Lewis, Intermediate Technology Publications, London, 1999.
Upregulation of Dorsal Root Ganglion α<sub>2</sub>δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats (2001)

Peripheral nerve injury can lead to a persistent neuropathic pain state in which innocuous tactile stimulation elicits pain behavior (tactile allodynia). Spinal administration of the anticonvulsant gabapentin suppresses allodynia by an unknown mechanism. In vitro studies indicate that gabapentin binds to the alpha(2)delta-1 (hereafter referred to as alpha(2)delta) subunit of voltage-gated calcium channels. We hypothesized that nerve injury may result in altered alpha(2)delta subunit expression in spinal cord and dorsal root ganglia (DRGs) and that this change may play a role in neuropathic pain processing. Using a rat neuropathic pain model in which gabapentin-sensitive tactile allodynia develops after tight ligation of the left fifth and sixth lumbar spinal nerves, we found a >17-fold, time-dependent increase in alpha(2)delta subunit expression in DRGs ipsilateral to the nerve injury. Marked alpha(2)delta subunit upregulation was also evident in rats with unilateral sciatic nerve crush, but not dorsal rhizotomy, indicating a peripheral origin of the expression regulation. The increased alpha(2)delta subunit expression preceded the allodynia onset and diminished in rats recovering from tactile allodynia. RNase protection experiments indicated that the DRG alpha(2)delta regulation was at the mRNA level. In contrast, calcium channel alpha(1B) and beta(3) subunit expression was not co-upregulated with the alpha(2)delta subunit after nerve injury. These data suggest that DRG alpha(2)delta regulation may play an unique role in neuroplasticity after peripheral nerve injury that may contribute to allodynia development.
Binding of nucleotides to an extramitochondrial acetyl-CoA hydrolase from rat liver (1988)

Cold labile extramitochondrial acetyl-CoA hydrolase (dimeric form) purified from rat liver was activated by various nucleoside triphosphates and inhibited by various nucleoside diphosphates. Activation of acetyl-CoA hydrolase by ATP was inhibited by a low concentration of ADP (Ki congruent to 6.8 microM) or a high concentration of AMP (Ki congruent to 2.3 mM). ADP and AMP were competitive inhibitors of ATP. A Scatchard plot of the binding of ATP to acetyl-CoA hydrolase (dimer) at room temperature gave a value of 25 microM for the dissociation constant with at least 2 binding sites/mol of dimer. Cold-treated monomeric enzyme also associated with ATP-agarose, suggesting that the monomeric form of the enzyme also has a nucleotide binding site(s), probably at least 1 binding site/mol of monomer. Phenylglyoxal or 2,3-butanedione, both of which modify arginyl residues of protein, inactivated acetyl-CoA hydrolase. ATP (an activator) greatly protected acetyl-CoA hydrolase from inactivation by these reagents, while ADP (an inhibitor) greatly (a substratelike, competitive inhibitor), and CoASH (a product) were less effective. However, addition of ADP plus valeryl-CoA (or CoASH) effectively prevented the inactivation by 2,3-butanedione, but that is not the case for phenylglyoxal. These results suggest that one or more arginyl residues are involved in the nucleotide binding site of extramitochondrial acetyl-CoA hydrolase and that their nucleotide binding sites locate near the substrate binding site.
Large scale copper vapor laser computer control system (1979)

High power pulse copper vapor laser systems consist of a master oscillator and numerous power amplifiers. Large systems used in laser isotope separation experiments require several automatic control systems. The rapid development of compact mini computers over the past several years has enabled the implementation of sophisticated computer controlled copper vapor laser systems. Present systems provide automatic time synchronization and input power stabilization. Future systems will incorporate semi-automatic start-up capabilities.
Practical Design Considerations for High-Frequency Soft-Switching PWM DC-DC Power Converter with Tapped Inductor Filter (2003)

In this paper, practical design considerations for the novel prototype of the high frequency transformer link full-bridge type soft-switching phase-shift PWM controlled DC-DC power converter with ZVS and ZCS bridge legs using tapped inductor filter are presented. The proposed tapped inductor filter assisted phase-shift PWM DC-DC converter can achieve constant frequency soft-switching operation under conditions of the wide load range and input voltage variations and to minimize circulating current, which occurs due to presence of the leakage inductance of the high frequency transformer. The optimum practical design of the tapped inductor turns ratio is significant to effectively reduce circulating current and achieve high efficiency of the DC-DC power conversion under 100kHz high frequency operation. The 1kW-100kHz with 36V input DC source and 100V output side breadboard circuit using the power MOSFETS is built and tested. The actual efficiency 97% is obtained at maximum.
World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics (2016)

WAO recommendations about prebiotic supplementation for the prevention of allergy are intended to support parents, clinicians and other health care professionals in their decisions whether or not to use prebiotics for the purpose of preventing allergies in healthy, term infants.
Berry pseudorotation and turnstile rotation (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleBerry pseudorotation and turnstile rotationIvar Ugi, Dieter Marquarding, Hans Klusacek, Paul Gillespie, and Fausto RamirezCite this: Acc. Chem. Res. 1971, 4, 8, 288–296Publication Date (Print):August 1, 1971Publication History Published online1 May 2002Published inissue 1 August 1971https://pubs.acs.org/doi/10.1021/ar50044a004https://doi.org/10.1021/ar50044a004research-articleACS PublicationsRequest reuse permissionsArticle Views2053Altmetric-Citations296LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Ultrastructural histochemical study of the mammary gland of the lactating rat]. (1982)

The authors report the results of their ultrastructural study on the lactating mammary gland of the rat using Grimelius' silver stain, modified for electron microscopy. The granules of the gland proteic ésocrine secretion are positive to silver impregnation, both within the cytoplasm and in the alveolar lumen. These results are interesting since they suggest that Grimelius' stain positive structures, in the mammary gland, should not be necessarily interpreted as endocrine, at least in the rat.
Scenarios of Next Generation Grid Applications in Collaborative Environments (2012)

The Grid has the potential to make a significant advance beyond the Internet, by turning it from a passive information medium into an active tool for creating and exploring new knowledge. Nowadays, this potential is becoming a reality and is emerging to Next Generation Grids (NGG) thanks to the far more cost-effective and universally applicable technology. Taking into consideration that Grids started delivering benefits to their adopters, this book chapter focuses on providing a business–technical presentation of two potential NGG applications, from two competitive and highly dynamic markets, including complex collaborations, which have shown rapid growth over the past decades; the supply chain management and the Cargo Transportation Logistics. The authors present a set of NGG components, the adoption of which in the aforementioned application domains addresses efficiently a set of technical issues ranging from performance to dynamic negotiation, and tackle the main trends and challenges in the corresponding business sectors.
자동차 보호용 아크릴 점착제의 제조 및 내성조사 (2006)

Acrylic adhesives for automobiles protection were prepared by emulsion polymerization. Monomers used were n-butyl acrylate(BA), acrylonitrile (AN),...
Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker (2014)

Improved insight into the molecular characteristics of the different ovarian cancer subgroups is needed for developing a more individualized and optimized treatment regimen. The aim of this study was to a) identify differentially expressed miRNAs in high-grade serous ovarian carcinoma (HGSC), clear cell ovarian carcinoma (CCC) and ovarian surface epithelium (OSE), b) evaluate selected miRNAs for association with clinical parameters including survival and c) map miRNA-mRNA interactions. Differences in miRNA expression between HGSC, CCC and OSE were analyzed by global miRNA expression profiling (Affymetrix GeneChip miRNA 2.0 Arrays, n = 12, 9 and 9, respectively), validated by RT-qPCR (n = 35, 19 and 9, respectively), and evaluated for associations with clinical parameters. For HGSC, differentially expressed miRNAs were linked to differentially expressed mRNAs identified previously. Differentially expressed miRNAs (n = 78) between HGSC, CCC and OSE were identified (FDR < 0.01%), of which 18 were validated (p < 0.01) using RT-qPCR in an extended cohort. Compared with OSE, miR-205-5p was the most overexpressed miRNA in HGSC. miR-200 family members and miR-182-5p were the most overexpressed in HGSC and CCC compared with OSE, whereas miR-383 was the most underexpressed. miR-205-5p and miR-200 members target epithelial-mesenchymal transition (EMT) regulators, apparently being important in tumor progression. miR-509-3-5p, miR-509-5p, miR-509-3p and miR-510 were among the strongest differentiators between HGSC and CCC, all being significantly overexpressed in CCC compared with HGSC. High miR-200c-3p expression was associated with poor progression-free (p = 0.031) and overall (p = 0.026) survival in HGSC patients. Interacting miRNA and mRNA targets, including those of a TP53-related pathway presented previously, were identified in HGSC. Several miRNAs differentially expressed between HGSC, CCC and OSE have been identified, suggesting a carcinogenetic role for these miRNAs. miR-200 family members, targeting EMT drivers, were mostly overexpressed in both subgroups, among which miR-200c-3p was associated with survival in HGSC patients. A set of miRNAs differentiates CCC from HGSC, of which miR-509-3-5p and miR-509-5p are the strongest classifiers. Several interactions between miRNAs and mRNAs in HGSC were mapped.