gebhart/patrepeval huggingface dataset:
HMSH6 alterations in patients with microsatellite instability-low colorectal cancer. (2000)

Two microsatellite instability (MSI) phenotypes have been described in colorectal cancer (CRC): MSI-H (instability at >30% of the loci examined) and MSI-L (MSI at 1-30% of the loci examined). The MSI-H phenotype, observed in both hereditary nonpolyposis colon cancer-associated CRC and approximately 15% of sporadic CRC, generally results from mutational or epigenetic inactivation of the DNA mismatch repair (MMR) genes hMSH2 or hMLH1. The genetic basis for the MSI-L phenotype, however, is unknown. Several other proteins, including hMSH3 and hMSH6, also participate in DNA MMR. Inactivating mutations of MSH6 in yeast and human tumor cell lines are associated with an impaired ability to repair single-base mispairs and small insertion-deletion loops but not large insertion-deletion loops. This suggests that hMSH6 mutations are more likely to be associated with a MSI-L phenotype than a MSI-H phenotype in CRC. To explore this possibility, we screened tumors from 41 patients with MSI-L CRC for hMSH6 mutations with conformation-sensitive gel electrophoresis (CSGE) and for hMSH6 protein expression by immunohistochemistry. Alterations found with CSGE were confirmed by DNA sequencing of normal and tumor tissue. One somatic (Asp389Asn) and 15 germ-line changes were found. Of the 15 germ-line changes, 9 were found in an intron (none involving splice junctions), and 6 were found in an exon (Gly39Glu, Leu395Val, and 4 silent alterations). Immunohistochemical staining for hMSH6 performed on 34 of the 41 tumors revealed strong nuclear hMSH6 expression in all of the cases. Overall, our results suggest that hMSH6 mutations do not play a major role in the development of sporadic CRC with a MSI-L phenotype.
Targeting the epithelial to mesenchymal transition in glioblastoma: the emerging role of MET signaling (2014)

Glioblastoma multiforme (GBM) is the most common human primary brain malignancy and has a dismal prognosis. Aggressive treatments using maximal surgical resection, radiotherapy, and temozolomide result in median survival of only 14.6 months in patients with GBM. Numerous clinical approaches using small molecule inhibitors have shown disappointing results because of the genetic heterogeneity of GBM. The epithelial to mesenchymal transition (EMT) is a crucial biological process occurring in the early development stages of many species. However, cancer cells often obtain the ability to invade and metastasize through the EMT, which triggers the scattering of cells. The hepatocyte growth factor (HGF)/MET signaling pathway is indicative of the EMT during both embryogenesis and the invasive growth of tumors, because HGF potently induces mesenchymal transition in epithelial-driven cells. Activation of MET signaling or co-overexpression of HGF and MET frequently represents aggressive growth and poor prognosis of various cancers, including GBM. Thus, efforts to treat cancers by inhibiting MET signaling using neutralizing antibodies or small molecule inhibitors have progressed during the last decade. In this review, we discuss HGF/MET signaling in the development of diseases, including cancers, as well as updates on MET inhibition therapy.
<scp>l</scp> -Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells (2014)

Enzymatic depletion of the nonessential amino acid l-Arginine (l-Arg) in patients with cancer by the administration of a pegylated form of the catabolic enzyme arginase I (peg-Arg I) has shown some promise as a therapeutic approach. However, l-Arg deprivation also suppresses T-cell responses in tumors. In this study, we sought to reconcile these observations by conducting a detailed analysis of the effects of peg-Arg I on normal T cells. Strikingly, we found that peg-Arg I blocked proliferation and cell-cycle progression in normal activated T cells without triggering apoptosis or blunting T-cell activation. These effects were associated with an inhibition of aerobic glycolysis in activated T cells, but not with significant alterations in mitochondrial oxidative respiration, which thereby regulated survival of T cells exposed to peg-Arg I. Further mechanistic investigations showed that the addition of citrulline, a metabolic precursor for l-Arg, rescued the antiproliferative effects of peg-Arg I on T cells in vitro. Moreover, serum levels of citrulline increased after in vivo administration of peg-Arg I. In support of the hypothesis that peg-Arg I acted indirectly to block T-cell responses in vivo, peg-Arg I inhibited T-cell proliferation in mice by inducing accumulation of myeloid-derived suppressor cells (MDSC). MDSC induction by peg-Arg I occurred through the general control nonrepressed-2 eIF2α kinase. Moreover, we found that peg-Arg I enhanced the growth of tumors in mice in a manner that correlated with higher MDSC numbers. Taken together, our results highlight the risks of the l-Arg-depleting therapy for cancer treatment and suggest a need for cotargeting MDSC in such therapeutic settings.
ChemInform Abstract: ION ACTIVITIES AND ZINC ELECTRODE REACTIONS IN CALCIUM CHLORIDE SOLUTIONS (1979)

Abstract In schwach sauren wäßrigen Lösungen mit 0.005 m ZnCl 2 + χ m CaCl 2 (x: 0.2‐6.0) (m: mol/kg) steigen die Aktivitätskoeffizienten der "nackten" Ionen nach einem Minimum bei χ ≈︁ 0.5 für Ca 2+ stark und für Cl ‐ schwach an, während sie für Zn 2+ aufgrund von Komplexbildung mit Cl ‐ stark abfallen.
A Heuristic Approach for Simulation of time-course Visual Adaptation for High Dynamic Image Streams (2007)

There is substantial evidence from earlier researches that older adults have difficult seeing under low illumination and at night, even in the absence of ocular diseases. During human aging, there is a rampant decrease in rod/cone-meditated adaptation which is caused by delayed rhodopsin regeneration and pigment depletion. This calls for a need to develop appropriate visual gadgets to effectively aid the aging generation. Our research culminates its approach from Pattanaik’s model by making extensions to temporal visual filtering, thereby simulating a reduction of visual response which comes with age. Our filtering model paves way and lays a foundation for future research to develop a more effective adaptation model that may be further used in developing visual content adaptation aids and guidelines in MPEG 21 environment. We demonstrate our visual model using a High Dynamic Range image and the experiment results are in conversant with the psychophysical data from previous vision researches.
Relationship between the EPR SI-5 Signal and the 0.65 eV Electron Trap in 4H- and 6H-SiC Polytypes (2006)

We used electron paramagnetic resonance (EPR) and deep-level transient spectroscopy (DLTS) to quantitatively compare the concentrations of the EPR signal originally known as SI-5 and the commonly observed DLTS signal at E c -0.65 eV in bulk and epitaxial 4H- and 6H-SiC.
Assigning the NMR spectra of aromatic amino acids in proteins: analysis of two Ets pointed domains (1998)

The measurement of interproton nuclear Overhauser enhancements (NOEs) and dihedral angle restraints of aromatic amino acids is a critical step towards determining the structure of a protein. The complete assignment of the resonances from aromatic rings and the subsequent resolution and identification of their associated NOEs, however, can be a difficult task. Shown here is a strategy for assigning the 1 H, 13 C, and 15 N signals from the aromatic side chains of histidine, tryptophan, tyrosine, and phenylalanine using a suite of homo- and hetero-nuclear scalar and NOE correlation experiments, as well as selective deuterium isotope labelling. In addition, a comparison of NOE information obtained from homonuclear NOE spectroscopy (NOESY) and 13 C-edited NOESY - heteronuclear single quantum correlation experiments indicates that high-resolution homonuclear two-dimensional NOESY spectra of selectively deuterated proteins are invaluable for obtaining distance restraints to the aromatic residues.Key words: NMR assignment, aromatic residue, transcription factor, NOE, dihedral angle.
<title>Medical image compression with embedded wavelet transform</title> (1997)

The need for effective medical image compression and transmission techniques continues to grow because of the huge volume of radiological images captured each year. The limited bandwidth and efficiency of current networking systems cannot meet this need. In response, Physical Optics Corporation devised an efficient medical image management system to significantly reduce the storage space and transmission bandwidth required for digitized medical images. The major functions of this system are: (1) compressing medical imagery, using a visual-lossless coder, to reduce the storage space required; (2) transmitting image data progressively, to use the transmission bandwidth efficiently; and (3) indexing medical imagery according to image characteristics, to enable automatic content-based retrieval. A novel scalable wavelet-based image coder was developed to implement the system. In addition to its high compression, this approach is scalable in both image size and quality. The system provides dramatic solutions to many medical image handling problems. One application is the efficient storage and fast transmission of medical images over picture archiving and communication systems. In addition to reducing costs, the potential impact on improving the quality and responsiveness of health care delivery in the US is significant.
Supplementary Figures S1-S4 from A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling (2023)

Supplementary Figures S1-S4 from A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling
Poster: Symbol detection with OR rule for CAN FD (2016)

Controller area network (CAN) is a communication standard for in-vehicle networks and is widely employed by a number of vehicle lines. Recently, it is required for CAN to enhance bit rate because in-vehicle devices are becoming high quality and their number is increasing. CAN with flexible data-rate (CAN FD) has been recently developed to enhance the throughput in in-vehicle networks. However, higher bit rate in the data phase of CAN FD will cause severe inter-symbol interference (ISI) due to ringing, and the communication may be disabled. In this paper, symbol detection with OR rule is proposed to improve the bit reliability. The simulation results show that the proposed symbol detection attains higher bit rate than the conventional one for test networks.
The Influence of Radiographic Phenotype and Smoking Status on Peripheral Blood Biomarker Patterns in Chronic Obstructive Pulmonary Disease (2009)

Airway and parenchymal phenotypes of COPD are associated with unique systemic serum biomarker profiles. Serum biomarker patterns may provide a more precise classification of the COPD syndrome, provide insights into disease pathogenesis and identify targets for novel patient-specific biological therapies.
Activation of C−S Bonds in Organosulfur Compounds Containing α,β‐Unsaturated Ketone Systems by Carbonylruthenium and ‐iron Complexes (2003)

Abstract Vinylidenetetraruthenium clusters have been obtained from the reactions between [Ru 3 (CO) 12 ] and [CH 3 C(O)CH=C(SCH 3 ) 2 ] or [(C 5 H 5 )Fe{C 5 H 4 CH=CHC(O)CH=C(SCH 2 CH 2 S)}] by cleavage of the S−C sp 2 bonds in these ligands. An excess of [CH 3 C(O)CH=C(SCH 3 ) 2 ] afforded the dinuclear complex [Ru 2 (CO) 4 (μ‐SCH 3 ) 2 {η 2 :κ‐ C , O ‐C(SCH 3 )CHC(O)CH 3 } 2 ], which was then converted into the vinylidene cluster [Ru 4 (CO) 10 (μ‐SCH 3 ) 2 {μ 4 ,η 3 :κ‐ C , C , O ‐C=CHC(O)CH 3 }] in the presence of more of the carbonylruthenium complex. However, the carbonyliron complex led to the formation of the dinuclear compounds [Fe 2 (CO) 4 (μ‐SCH 3 ) 2 {η 2 :κ‐ C , O ‐C(SCH 3 )CHC(O)CH 3 } 2 ] and [Fe 2 (CO) 5 {μ,η 4 :κ‐ C , O , S , S ‐(SCH 2 CH 2 S)C=CHC(O)CH=CHC 5 H 4 }Fe(C 5 H 5 )]. All of the new complexes exhibit a pentametallacycle group as a consequence of the rupture of the S−C bonds, as well as the presence of the C(O)R substituent in these ligands. The compounds have been characterised by analytical and spectroscopic data and the crystal structures of some of them have been solved by X‐ray diffraction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Formation of order in a system of localized charges in disordered layers of solid solutions of cadmium telluride and cadmium sulfide (1997)

Relaxation processes stimulated in layers of the solid solutions CdTexS1−x (x<0.2) by a change in an external electric field, temperature, and illumination have been studied. Polarization effects and maxima of the inversion current of photostimulated and thermally stimulated polarization were found. It is shown that all characteristic features of the relaxation processes can be explained in a quasidipole model, and the inversion maxima of the current can be interpreted as being due to a photostimulated and thermally stimulated order-disorder transition.
Hypothermic machine perfusion of kidneys retrieved from standard and high-risk donors (2015)

Hypothermic machine perfusion (HMP) of kidneys is a long-established alternative to static cold storage and has been suggested to be a better preservation method. Today, as our deceased donor profile continues to change towards higher-risk kidneys of lower quality, we are confronted with the limits of cold storage. Interest in HMP as a preservation technique is on the rise. Furthermore, HMP also creates a window of opportunity during which to assess the viability and quality of the graft before transplantation. The technology might also provide a platform during which the graft could be actively repaired, making it particularly attractive for higher-risk kidneys. We review the current evidence on HMP in kidney transplantation and provide an outlook for the use of the technology in the years to come.
Pioglitazone, a PPAR-gamma ligand, exerts cytostatic/cytotoxic effects against cancer cells, that do not result from inhibition of proteasome. (2008)

Thiazolidinediones are oral antidiabetic agents that activate peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and exert potent antioxidant and anti-inflammatory properties. It has also been shown that PPAR-gamma agonists induce G0/G1 arrest and apoptosis of malignant cells. Some of these effects have been suggested to result from inhibition of proteasome activity in target cells. The aim of our studies was to critically evaluate the cytostatic/cytotoxic effects of one of thiazolidinediones (pioglitazone) and its influence on proteasome activity. Pioglitazone exerted dose-dependent cytostatic/cytotoxic effects in MIA PaCa-2 cells. Incubation of tumor cells with pioglitazone resulted in increased levels of p53 and p27 and decreased levels of cyclin D1. Accumulation of polyubiquitinated proteins within cells incubated with pioglitazone suggested dysfunction of proteasome activity. However, we did not observe any influence of pioglitazone on the activity of isolated proteasome and on the proteolytic activity in lysates of pioglitazone-treated MIA PaCa-2 cells. Further, treatment with pioglitazone did not cause an accumulation of fluorescent proteasome substrates in transfected HeLa cells expressing unstable GFP variants. Our results indicate that pioglitazone does not act as a direct or indirect proteasome inhibitor.
A Reliability and Utility Study of the Care Dependency Scale (2000)

The purpose of this study was to examine the reliability and utility of the Care Dependency Scale (CDS). This 15-item scale has been developed recently for assessing the care dependency of demented or mentally handicapped inpatients. Data for this study were collected from 153 demented and 139 mentally handicapped inpatients. The sample was measured three times. Internal consistency was determined using Cronbach's alpha and ranged from 0.95 to 0.97. Interrater reliability revealed moderate to substantial weighted Kappa statistics between 0.51 and 0.83. Test-retest reliability analysis resulted in substantial weighted Kappas between 0.66 and 0.89. Utility tests also revealed satisfactory results. The findings support the reliability and utility of the CDS.
Reviews (1989)

Reviews K. Barry , Language, Music and the Sign. A Study in Aesthetics, Poetics and Poetic Practice from Collins to Coleridge . Pp. xii + 244 . Cambridge, New York, New Rochelle, Melbourne, Sydney : Cambridge University Press , 1987 . Hardbound £25.00; paperbound £11.50. NICHOLAS ROE NICHOLAS ROE University of St Andrews Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 36, Issue 1, March 1989, Pages 115-b–115, https://doi.org/10.1093/nq/36-1-115b Published: 01 March 1989
Remote microwave technology for chamber clean to reduce PFC emissions (2002)

Applied Materials has developed a new chamber cleaning technology that has the potential to dramatically reduce PFC emissions from chamber cleaning on their D/spl times/Z/sup TM/ platform. The prototype product, known as /spl mu/Clean/sup TM/, is a remote microwave clean using NF/sub 3/ that can be retrofitted to a D/spl times/Z chamber. Recent tests of /spl mu/Clean technology conducted by Air Products and Chemicals, Inc. at Applied Materials have demonstrated the high utilization efficiencies of NF/sub 3/ (>90%) and reduced clean times. To confirm these results in an actual manufacturing environment, Motorola installed a prototype unit on an 200 mm Applied Materials D/spl times/Z plasma enhanced TEOS (PETEOS) chamber. Both quadrapole mass spectrometry (QMS) and Fourier transform infrared spectroscopy (FTIR) were used to quantify the major fluorinated gases in the process effluent. Process impact was determined by clean times, particle generation, and film thickness uniformity in the tool. The Applied Materials /spl mu/Clean technology has been shown to be effective for 200 mm D/spl times/Z TEOS chamber cleaning. Throughout a 500 wafer marathon, and during subsequent product processing beyond 13,000 wafers, no negative effect on manufacturing parameters has been noted. There is no evidence of particle generation and film properties are seemingly unaffected by the remote NF/sub 3/ clean. The Applied Materials /spl mu/Clean technology has been shown to be a viable alternative to the standard C/sub 2/F/sub 6/-NF/sub 3/ clean used in 200 mm D/spl times/Z TEOS chambers. PFC emissions are virtually eliminated without affecting the manufacturing process.
A wide input voltage range ZVS isolated bidirectional DC-DC converter for ultra-capacitor application in hybrid and electric vehicles (2012)

This paper presents a new wide input voltage range ZVS isolated bidirectional DC/DC converter for an ultra-capacitor module used as an auxiliary power supply in electric vehicles. Compared to the conventional bidirectional converters, this modified circuit minimizes device current stress over a wide input voltage range. A natural zero-voltage switching for the transformer-connected switches is achieved without additional device. Moreover, reverse-recovery process of the diode of the transformer-connected switch module is avoided. These two features promise high operation frequency of transformer to improve power density. These advantages make the new converter promising for high power density applications especially to overcome high device current stress problem. In this paper, firstly, a completed design consideration of the new topology is presented; secondly, an analysis of operation is provided; finally, a 9-21V/66V 500W prototype is built up and it successfully proved this converter's device current stresses minimization and high power density characteristics.
Colloid cysts of the third ventricle: correlation of MR and CT findings with histology and chemical analysis. (1990)

Eight patients with colloid cysts of the third ventricle were examined with CT and MR. In six, surgical resection was performed and the material was subjected to histologic evaluation; the concentrations of trace elements were determined by particle-induced X-ray emission. Stereotaxic aspiration was performed in two. The investigation showed that colloid cysts are often iso- or hypodense relative to brain on CT (5/8), but sometimes have a center of increased density. Increased density did not correlate with increased concentration of calcium or other metals but did not correlate with high cholesterol content. Colloid cysts appear more heterogeneous on MR (6/8) than on CT (3/8), despite a homogeneous appearance at histology. High signal on short TR/TE sequences is correlated with a high cholesterol content. A marked shortening of the T2 relaxation time is often noticed in the central part of the cyst. Analysis of trace elements showed that this phenomenon is not related to the presence of metals with paramagnetic effects. Our analysis of the contents of colloid cysts does not support the theory that differing metallic concentrations are responsible for differences in MR signal intensity or CT density. We did find that increased CT density and high MR signal correlated with high cholesterol content.
Occupation number representation (2001)

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Weaving Genetically Engineered Functionality into Mechanically Robust Virus Fibers (2007)

Functionality-tunable fibers fabricated from the M13 virus are found to have mechanical toughness and strength comparable to synthetic homopolymer fibers. The desired functionality can be programmed by manipulating the virus genome (see figure and cover). The tunable functionalities and mechanical properties of the virus fibers show the promise of various applications. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c2262_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
C3-Symmetrical lanthanide podates organized by intramolecular trifurcated hydrogen bonds (1999)

The protonated tripodal podand [L6 + H]+ forms stable and organized monometallic podates [Ln(L6 + H)]4+ where LnIII is facially nine-coordinated by three wrapped unsymmetrical tridentate binding units. An unusual trifurcated hydrogen bond assists the organisation of the covalent tripod.