gebhart/patrepeval huggingface dataset:
Genetic population structure of marine viral haemorrhagic septicaemia virus (VHSV) (2004)

The nucleotide sequences of a specific region of the nucleoprotein gene were compared in order to investigate the genetic population structure of marine viral haemorrhagic septicaemia virus (VHSV). Analysis of the sequence from 128 isolates of diverse geographic and host origin renders this the most comprehensive molecular epidemiological study of marine VHSV conducted to date. Phylogenetic analysis of nucleoprotein gene sequences confirmed the existence of the 4 major genotypes previously identified based on N- and subsequent G-gene based analyses. The range of Genotype I included subgroups of isolates associated with rainbow trout aquaculture (Genotype Ia) and those from the Baltic marine environment (Genotype Ib) to emphasise the relatively close genetic relationship between these isolates. The existence of an additional genotype circulating within the Baltic Sea (Genotype II) was also confirmed. Genotype III included marine isolates from around the British Isles in addition to those associated with turbot mariculture, highlighting a continued risk to the development of this industry. Genotype IV consisted of isolates from the marine environment in North America. Taken together, these findings suggest a marine origin of VHSV in rainbow trout aquaculture. The implications of these findings with respect to the future control of VHSV are discussed. The capacity for molecular phylogenetic analysis to resolve complex epidemiological problems is also demonstrated and its likely future importance to disease management issues highlighted.
Endothelial microparticles reduce <scp>ICAM</scp>‐1 expression in a micro<scp>RNA</scp>‐222‐dependent mechanism (2015)

Endothelial microparticles (EMP) are released from activated or apoptotic endothelial cells (ECs) and can be taken up by adjacent ECs, but their effect on vascular inflammation after engulfment is largely unknown. We sought to determine the role of EMP in EC inflammation. In vitro, EMP treatment significantly reduced tumour necrosis factor-α-induced endothelial intercellular adhesion molecule (ICAM)-1 expression on mRNA and protein level, whereas there was no effect on vascular cell adhesion molecule-1 expression. Reduced ICAM-1 expression after EMP treatment resulted in diminished monocyte adhesion in vitro. In vivo, systemic treatment of ApoE-/- mice with EMP significantly reduced murine endothelial ICAM-1 expression. To explore the underlying mechanisms, Taqman microRNA array was performed and microRNA (miR)-222 was identified as the strongest regulated miR between EMP and ECs. Following experiments demonstrated that miR-222 was transported into recipient ECs by EMP and functionally regulated expression of its target protein ICAM-1 in vitro and in vivo. After simulating diabetic conditions, EMP derived from glucose-treated ECs contained significantly lower amounts of miR-222 and showed reduced anti-inflammatory capacity in vitro and in vivo. Finally, circulating miR-222 level was diminished in patients with coronary artery disease (CAD) compared to patients without CAD. EMPs promote anti-inflammatory effects in vitro and in vivo by reducing endothelial ICAM-1 expression via the transfer of functional miR-222 into recipient cells. In pathological hyperglycaemic conditions, EMP-mediated miR-222-dependent anti-inflammatory effects are reduced.
The Labyrinthine Workings of the Nursing Home Business (2018)

A look inside an opaque industry that often puts profits over patient care.
Practical Issues in Mixed-Initiative Natural Language Dialog: Experimental Perspective (1997)

There are several theoretical and technical challenges to be resolved in developing effective computational models for mixed-initiative interaction. This paper describes some of the unresolved challenges encountered in the development of a computational model of dialog processing. This model was implemented in the Circuit Fix-It Shop, a spoken natural language dialog system that was experimentally evaluated with eight different users in 141 problem-solving dialogs. From our experiences in developing a system capable of experimental evaluation we have noted at least three difficulties in modeling mixed-initiative interaction: (1) maintaining coherence during an initiative change; (2) choosing an appropriate linguistic form for a response as a function of initiative; and (3) processing silence as a legitimate input and output. Our experiences in dealing with these issues are the focus of discussion in this paper. Introduction There are several theoretical and technical challenges to be ...
Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. (2000)

The authors examined the association of incident dementia and subtypes with age, sex, and geographic area in Europe. Incidence data from eight population-based studies carried out in seven European countries were compared and pooled. The pooled data included 835 mild to severe dementia cases and 42,996 person-years of follow-up. In all studies a higher proportion of cases were diagnosed with AD (60 to 70% of all demented cases) than vascular dementia (VaD). The incidence of dementia and AD continued to increase with age up to age 85 years, after which rates increased in women but not men. There was a large variation in VaD incidence across studies. In the pooled analysis, the incidence rates increased with age without any substantial difference between men and women. Surprisingly, higher incidence rates of dementia and AD were found in the very old in northwest countries than in southern countries. This study confirms that AD is the most frequent dementing disorder in all ages, and that there is a higher incidence of dementia, specifically AD, in women than men among the very old. Finally, there may be regional differences in dementia incidence.
Tumor necrosis factor-&alpha; serum levels in healthy smokers and nonsmokers (2010)

The high levels of TNF-alpha in the serum of smokers suggest an imbalance between the proinflammatory and anti-inflammatory factors as a result of tobacco smoke exposure. The concentration of TNF-alpha is elevated in the serum of healthy heavy smokers in a cigarette dose-dependent manner. We speculate that the serum level of TNF-alpha might be a useful biomarker for the selection of heavy smokers with a high risk of developing smoke induced pulmonary diseases.
Evolution of Catalases from Bacteria to Humans (2008)

Excessive hydrogen peroxide is harmful for almost all cell components, so its rapid and efficient removal is of essential importance for aerobically living organisms. Conversely, hydrogen peroxide acts as a second messenger in signal-transduction pathways. H(2)O(2) is degraded by peroxidases and catalases, the latter being able both to reduce H(2)O(2) to water and to oxidize it to molecular oxygen. Nature has evolved three protein families that are able to catalyze this dismutation at reasonable rates. Two of the protein families are heme enzymes: typical catalases and catalase-peroxidases. Typical catalases comprise the most abundant group found in Eubacteria, Archaeabacteria, Protista, Fungi, Plantae, and Animalia, whereas catalase-peroxidases are not found in plants and animals and exhibit both catalatic and peroxidatic activities. The third group is a minor bacterial protein family with a dimanganese active site called manganese catalases. Although catalyzing the same reaction (2 H(2)O(2)--> 2 H(2)O+ O(2)), the three groups differ significantly in their overall and active-site architecture and the mechanism of reaction. Here, we present an overview of the distribution, phylogeny, structure, and function of these enzymes. Additionally, we report about their physiologic role, response to oxidative stress, and about diseases related to catalase deficiency in humans.
Selenium and Glutathione Peroxidase Status in Paediatric Health and Gastrointestinal Disease (1994)

To examine the effect of paediatric GI disease on selenium concentration in plasma and glutathione peroxidase activity in plasma and red cells, results in children with Crohn's disease (n = 39), cystic fibrosis (n = 14), intractable diarrhoea (n = 13), and biliary atresia (n = 10) were compared with those from 86 healthy children undergoing routine operations. In Crohn's disease, plasma selenium concentrations were rarely low, but glutathione peroxidase activity was increased in the plasma and reduced in the red cells. Selenium concentration and glutathione peroxidase activity increased with steroid treatment but decreased with a selenium-deficient elemental diet. Plasma selenium concentration was normal in children with cystic fibrosis but very low in severely malnourished children with biliary atresia and intractable diarrhoea. Selenium concentration and glutathione peroxidase activity should be monitored in children with severe malnutrition or requiring prolonged nutritional support. Supplementation is recommended in cases of severe selenium depletion.
[Does Masui's Ca-sensitive cytostatic factor exist in the cytoplasm of mature nonactivated eggs of Acipenser stellatus, Rana temporaria and Xenopus laevis?]. (1984)

The cytoplasm of mature non-activated and cleaving eggs of A. stellatus and R. temporaria had no cytostatic effect. The cytoplasm treated with EGTA, being injected in one of two blastomeres of the cleaving egg of the same species, inhibits fully or partially the cleavage. The nuclei in the "arrested" blastomeres had, however, vesicular structure but were not blocked at metaphase, as could be expected if the cleavage was inhibited by a cytostatic factor described by Masui (1974). The portion of perished embryos and "arrested" blastomeres was shown to increase with the dose of EGTA injected in the egg, donor of cytoplasm. In the experiments with reciprocal injections of the intact cytoplasm of the mature non-activated eggs in one of two blastomeres of the recipient embryo carried out on R. temporaria and X. laevis, the cytoplasm of X. laevis only arested the cleavage but in this case as well only 4 out of 32 "arrested" blastomeres were at metaphase. The cytostatic effect observed in our experiments was not, hence, similar to that observed by Masui on R. pipiens.
The Preparation of Acetopropyl Alcohol and 1,4-Pentanediol from Methylfuran<sup>2</sup> (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Acetopropyl Alcohol and 1,4-Pentanediol from Methylfuran2L. E. Schniepp, H. H. Geller, and R. W. von KorffCite this: J. Am. Chem. Soc. 1947, 69, 3, 672–674Publication Date (Print):March 1, 1947Publication History Published online1 May 2002Published inissue 1 March 1947https://pubs.acs.org/doi/10.1021/ja01195a061https://doi.org/10.1021/ja01195a061research-articleACS PublicationsRequest reuse permissionsArticle Views705Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wirkung von Ca‐Ionen bei Extraktgewinnung und Extraktreinigung in der Zuckerindustrie. 3. Mitt. Einwirkung von Calciumcarbonat auf Rübenmark (1976)

Abstract Es konnte nachgewiesen werden, daß Rübenmark aus gesättigten CaCO 3 ‐Lösungen oder CaCO 3 ‐Aufschlämmungen das Ca‐Ion vornehmlich gegen H‐Ionen austauscht.
A novel shallow trench isolation technology using LPCVD MTO/SiN liner in SOI wafer (2002)

A novel Shallow Trench Isolation (STI) technology has been proposed for the device fabrication using SOI wafers. The trench sidewall oxidation is replaced with MTO (Medium Temperature Oxide) and Silicon Nitride (SiN) to prevent the SOI bending problem. SiN Liner over MTO scheme showed the additional benefits such as reduced field oxide recess and improved gate oxide quality, Stress Induced Leakage Current (SILC) and Time Zero Dielectric Breakdown (TZDB). We also compared the bonded SOI and SIMOX wafers in terms of the gate oxide quality for the different STI liner schemes.
Further fractionations of histones from calf thymus (1962)

Research Article| January 01 1962 Further fractionations of histones from calf thymus EW JOHNS; EW JOHNS Search for other works by this author on: This Site PubMed Google Scholar JAV BUTLER JAV BUTLER Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1962) 82 (1): 15–18. https://doi.org/10.1042/bj0820015 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation EW JOHNS, JAV BUTLER; Further fractionations of histones from calf thymus. Biochem J 1 January 1962; 82 (1): 15–18. doi: https://doi.org/10.1042/bj0820015 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1962 The Biochemical Society1962 Article PDF first page preview Close Modal You do not currently have access to this content.
Ab Initio Computational Chemical Studies of Molecular Processes and Decomposition in Ammonium Perchlorate (2004)

Ammonium perchlorate is widely used as an oxidiser in composite propellants for rocket motors. Its decomposition is of interest in stability, sensitivity and combustion studies for rocket motor safety and performance analysis and prediction. This document presents some theoretical studies conducted to yield insights into the mechanisms and kinetics of ammonium perchlorate decomposition.
Report of an outbreak of swine fever in Auckland (1954)

Abstract Extract Swine fever is an acute septicaemic disease, caused by a filterable virus, producing high fever and prostration, with frequently almost 100% morbidity and mortality, and characterised on post mortem by haemorrhages in skin, kidney, spleen and lymph glands. It is widely recognized as a very serious disease in overseas countries. The cost of annual control in the U.S.A. alone is estimated at £10,000,000. The virus of swine fever can be easily carried by animate and inanimate objects, is fairly resistant to natural destruction and is readily communicable. Strenuous efforts have been made in the past to keep it out of this country. Considerable loss occurs in an outbreak and, if uncontrolled, swine fever would spread extremely rapidly and gain a firm hold. In countries like America and England, the disease has got so far out of hand that the slaughter policy is impracticable and a costly vaccination campaign is the only method of controlling the disease.
Temperature control of glass melting furnace with fuzzy logic and conventional PI control (2000)

This paper presents a practical application of fuzzy logic control of the temperature of glass-melting furnace. Because of the complexity and nonlinearity, temperature control of glass-melting furnace is still delegated to human operator. Though the overall characteristics of glass-melting furnace are complex and nonlinear, one portion of the furnace characteristics can be modeled as a linear system. The linear portion of the furnace dynamics is modeled with a first-order-plus-dead-time (FOPDT) system and a PI controller is applied to the FOPDT model. The remaining complex and nonlinear portion of the furnace dynamics is covered by the fuzzy system, i.e., rules of human experts. The PI controller and fuzzy system are combined in cascade. Practical implementation results of Samsung-Corning Company showed the effectiveness of proposed control algorithm.
The role of interleukin-8 in inflammation and mechanisms of regulation. (1993)

Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it has a distinct target specificity for the neutrophil, with only weak effects on other blood cells. Interleukin-8 attracts and activates neutrophils in inflammatory regions. The importance of neutrophil functions has been recognized in periodontal disease for many years. Neutrophils represent the major population of immigrant cells in periodontitis. In diseases with neutrophil dysfunctions periodontal tissue is lost very rapidly. The response of neutrophils to IL-8 is characterized by migration of the cells, the release of granule enzymes, and other intra- and extracellular changes. Connective tissue constituents are efficiently degraded by neutrophil enzymes, released upon activation. Interleukin-8 is a member of the Interleukin-8 supergene family that includes other small chemotactic peptides with structural homology. It also shares with other cytokines DNA sequence features that suggest common regulatory pathways. In vivo intracutaneous application of IL-8 induces local exudation and a massive, long-lasting accumulation of neutrophils. Though IL-8 plays a role in the cytokine network, its major pathophysiological role lies in affecting neutrophils. This article presents a review of literature on the current knowledge of IL-8, its mechanisms of expression, and the effects it exerts on the neutrophil.
Schematic pseudocode for program constructs and its computer automation by SCHEMACODE (1986)

To achieve program control flow representation that is relatively independent of any given programming language, schematic pseudocode (SPC) uses a perceptual notation system composed of schemata whose syntax rules are described by a grammar. Source code documentation is supported by operational comments, and translation into a target procedural language is fully automatic.
A new schizomid whipscorpion from California with notes on the other (Uropygi: Schizomidae) (1966)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
<title>New scheme of coherent array detection to cancel out phase fluctuations and Doppler frequency shift due to atmospheric turbulence and target movement for laser communications</title> (1999)

A coherent array detection system, which uses multiple independent apertures/receivers whose IFs are electro- optically co-phased in real time and then added together, can mitigate the laser signal fluctuations and fading due to atmospheric turbulence for laser communications and radar. Thus the system performance greatly depends on the electo- optic phase-locked loops (EOPLL) used for the real time co- phase of signals from the independent aperture/receivers. But if the fast phase fluctuations due to atmospheric turbulence or a high Doppler frequency shift due to the target (satellite) movement are induced to the laser signal which is beyond the response speed of the EOPLL, the system can not mitigate the signal fluctuations and fading anymore. This paper presents a new scheme which can make the coherent array detection system get rid of the EOPLL. This scheme uses a reference laser beam as well as laser signal with different polarization as the transmitted beam. By separating the received laser reference beam and signal due to their polarization and through two stage mixing, the IF signals from the multiple independent aperture/receivers will be co-phased automatically.
Kineanthropometric profile of weightlifters of different age and gender categories in the Coquimbo region (2020)

espanol: La composicion corporal de los deportistas entrega informacion importante de estos y permite manejar tanto la dieta que se les administra como la planificacion del entrenamiento. Es sabido que un entrenamiento de sobrecarga estimula el desarrollo muscular, asi como la perdida de tejido adiposo. Una buena planificacion del entrenamiento da como resultado cambios en la composicion corporal de los deportistas. Se realizaron dos mediciones en el tiempo de la composicion corporal de deportistas de levantamiento de pesas Hombres y Mujeres, y se las comparo. Los resultados obtenidos mostraron un aumento de masa muscular, al mismo tiempo que el tejido adiposo se mantenia o disminuia para ambos casos. A modo grafico se incluyo la carga de entrenamiento a la que fueron sometidos los deportistas y se observo como a medida que disminuia la cantidad de repeticiones (carga de entrenamiento), aumentaba la intensidad, la cual esta relacionada con el aumento de la masa muscular. Los resultados obtenidos en esta investigacion presentan un avance en las ciencias del deporte para chile asi como apoyo para entender mejor como influye el entrenamiento en la composicion corporal de los deportistas. Palabras claves: Periodizacion – Alterfilistas – Composicion corporal - Somatotipo EnglishThe body composition of athletes provides important information about them and allows them to manage both the diet administered to them and the planning of training. Overload training is known to stimulate muscle development as well as the loss of adipose tissue. Good training planning results in changes in the body composition of athletes. Two measurements over time of the body composition of male and female weightlifting athletes were made and compared. The results obtained showed an increase in muscle mass, at the same time that the adipose tissue was maintained or decreased for both cases. The training load to which the athletes were subjected was included graphically and it was observed how as the number of repetitions decreased (training load), the intensity increased, which is related to the increase in muscle mass. The results obtained in this research present an advance in sports science for Chile as well as support to better understand how training influences the body composition of athletes.Key words: Periodization - Alterfilistas - Body composition - Somatotype
BLCS 98 13th British Liquid Crystal Society Annual Meeting Bodington Hall, Leeds, UK, 6–8 April, 1998 (1998)

Abstract The 13th Annual British Liquid Crystal Society meeting was hosted by Professor Neville Boden at Leeds University. The conference was held at Bodington Hall, a single site conference venue three miles to the north of the University and city centre. BLCS 98 was attended by 123 delegates from academe and industry, and was kindly sponsored by Linkam Scientific, Taylor & Francis and Novocontrol International.
Structural Estimation of the Affiliated Private Value Auction Model (2002)

We consider the structural estimation of the affiliated private value (APV) model in first-price sealed-bid auctions. The model allows for bidders' individual efficiencies and opportunity costs, while permitting dependence among bidders' private values through affiliation. We establish the nonparametric identification of the APV model, characterize its theoretical restrictions, and propose a computationally convenient and consistent two-step nonparametric estimation procedure for estimating the joint private value distribution from observed bids. Using simulated bid data, we provide a step-by-step guide on how to implement our procedure and show the good behavior of our estimator in small samples.