gebhart/patrepeval huggingface dataset:
Growth Hormone-Binding Proteins (1993)

The recognition of circulating GHBP has added a new element of complexity to the GH-IGF axis. At the same time, it has facilitated investigation of that axis. The nature of the high-affinity GHBP as a “circulating receptor“, is particularly intriguing. This property has been useful for probing the GH receptor in humans, in whom direct receptor measurements are difficult. The high-affinity GHBP is positively linked, directly or indirectly, to the growth-promoting action of GH. Little is known about the significance of the low-affinity GHBP. The ultimate physiologic role of GHBP still remains to be defined. The development of simple and reliable assays for GHBP (46, 50, 116) that can be applied on a routine basis should facilitate the rapid accumulation of new knowledge in this field.
New paradigms for the use of prebiotics, probiotics, and synbiotics in renal disease (2011)

Abstract Prebiotics, probiotics, and synbiotics are now used more commonly in medicine, and they are generally considered to be dietary supplements and not drugs. They are not meant to be used for the treatment of disease, although recent interest has grown in the area of disease treatment. Not all of the research is in support of the benefit provided by these supplements, and it is important to be aware of the associated risks and benefi ts. In nephrology, these supplements show potential benefi ts in treating kidney stones, uremia, and urinary tract infections. This paper reviews the current literature with an emphasis on the risks and benefi ts of these supplements in the treatment of these renal disorders.
Concise Total Syntheses of Aspalathin and Nothofagin (2010)

Syntheses of the C-glycosyl flavone natural products aspalathin and nothofagin have been accomplished in eight steps from tribenzyl glucal, tribenzylphloroglucinol, and either 4-(benzyloxy)phenylacetylene or 3,4-bis(benzyloxy)phenylacetylene. The key step of the syntheses involves a highly stereoselective Lewis acid promoted coupling of 1,2-di-O-acyl-3,4,6-tribenzylglucose with tribenzylphloroglucinol, which gives rise to the corresponding beta-C-aryl glycoside in 30-65% yields.
Topology of the support of the two-dimensional random walk (1996)

We study the support (i.e. the set of visited sites) of a t step random walk on a two-dimensional square lattice in the large t limit. A broad class of global properties M(t) of the support is considered, including, e.g., the number S(t) of its sites; the length of its boundary; the number of islands of unvisited sites that it encloses; the number of such islands of given shape, size, and orientation; and the number of occurrences in space of specific local patterns of visited and unvisited sites. On a finite lattice we determine the scaling functions that describe the averages on appropriate lattice size dependent time scales. On an infinite lattice we first observe that the all increase with t as t/\log^k t, where k is an M dependent positive integer. We then consider the class of random processes constituted by the fluctuations around average Delta M(t). We show that to leading order as t gets large these fluctuations are all proportional to a single universal random process eta(t), normalized to =1$. For t--> infinity the probability law of eta(t) tends to that of Varadhan's renormalized local time of self-intersections. An implication is that in the long time limit all Delta M(t) are proportional to Delta S(t).
The PedsQL™ Family Impact Module: Preliminary reliability and validity (2004)

The results demonstrate the preliminary reliability and validity of the PedsQL Family Impact Module in families with children with complex chronic health conditions. The PedsQL Family Impact Module will be further field tested to determine the measurement properties of this new instrument with other pediatric chronic health conditions.
Efficiency Evaluation Metrics for Wireless Intelligent Sensors Applications (2014)

The metrology field has been progressed with the appearance of the wireless intelligent sensor systems providing more capabilities such as signal processing, remote multisensing fusion etc. This kind of devices is rapidly making their way into medical and industrial monitoring, collision avoidance, traffic control, automotive and others applications. However, numerous design challenges for wireless intelligent sensors systems are imposed to overcome the physical limitations in data traffic, such as system noise, real time communication, signal attenuation, response dynamics, power consumption, and effective conversion rates etc, especially for applications requiring specific performances. This paper analyzes the performance metrics of the mentioned sensing devices systems which stands for superior measurement, more accuracy and reliability. Study findings prescribe researchers, developers/ engineers and users to realizing an optimal sensing motes design strategy that offers operational advantages which can offer cost-effective solutions for an application.
Gastric parietal cell antigens of 60–90, 92, and 100–120 kDa associated with autoimmune gastritis and pernicious anemia (1989)

Thirty-four human sera containing parietal cell autoantibodies (PCA) specifically immunoprecipitated two antigens, with apparent molecular masses of 60-90 kDa and 100-120 kDa under nonreducing conditions and 60-90 kDa and 120-150 kDa under reducing conditions, from porcine gastric membrane extracts. A third antigen of 92 kDa was only observed in immunoprecipitates analyzed under reducing conditions. By immunoblotting, 24 of the 34 PCA-positive sera reacted with only the 60-90-kDa antigen, three reacted with a broad 60-120-kDa smear, one reacted only with a 92-kDa antigen and six did not react. Reactivity with the 60-90-kDa antigen was observed with gastric membranes from dog, pig, rat, and rabbit. Twenty PCA-negative sera did not react with these components by immunoprecipitation or immunoblotting. PCA reactivity with the 60-90-kDa antigen was abolished when the gastric membranes were (a) digested with Pronase, (b) reduced with 100 mM dithiothreitol, (c) treated with sodium periodate, or (d) digested with N-glycanase. The 60-90-kDa and 100-120-kDa components were insensitive to neuraminidase treatment. N-glycanase digestion of 125I-labeled antigens purified by immunoprecipitation and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis collapsed the 60-90-kDa antigen to a sharp 34-kDa band; the 100-120-kDa component was unaffected. These observations suggest that (i) parietal cell antigens comprise three components of 60-90, 92, and 100-120 kDa; (ii) the epitopes differ in conformational sensitivity; (iii) the 60-90-kDa antigen is a conserved molecule comprising a 34-kDa core protein extensively glycosylated with N-linked oligosaccharides; (iv) sialic acid residues are not present in the 60-90- and 100-120-kDa molecules, and (v) the carbohydrate and protein moieties of the 60-90-kDa molecule are required for antibody binding.
THE IMPORTANT ROLE OF HISTORICAL FLOOD DATA IN THE ESTIMATION OF SPILLWAY DESIGN FLOODS (1975)

It is well known that significant sampling errors are always involved in estimating the spillway design storm floods by the method of frequency analysis with limited streamflow records. For many streams the occurrence of a new great flood would lead to a significant change in the original design values thus computed. However, defects of this kind may be apparently made up if the design flood is com- puted by referring to the data of several great historical floods, of which the discharge and rare occurrence are obtained with good reliability. Our work and some understanding in this respect are presented briefly in this paper.
Porous Low-Dielectric-Constant Material for Semiconductor Microelectronics (2019)

To provide high speed, low dynamic power dissipation, and low cross-talk noise for microelectronic circuits, low-dielectric-constant (low-k) materials are required as the inter-and intra-level dielectric (ILD) insulator of the back-end-of-line interconnects. Porous low-k materials have low-polarizability chemical compositions and the introducing porosity in the film. Integration of porous low-k materials into microelectronic circuits, however, poses a number of challenges because the composition and porosity affected the resistance to damage during integration processing and reduced the mechanical strength, thereby degrading the properties and reliability. These issues arising from porous low-k materials are the subject of the present chapter.
Joint mobility changes due to low frequency vibration and stretching exercise (1976)

It has been shown that fifteen minutes of locally applied cycloid vibration of low amplitude and frequency is equally as effective as a fifteen minute programme of flexibility exercises in increasing short term mobility of the hip flexors. It is suggested that this mobility change may occur as a result of improved muscle relaxation.
Structure and concepts for current-based analog scan (2002)

This paper presents the structure of a current-based analog scan cell for analog and mixed-signal design-for-test. The cell uses current to represent the analog signal to be scanned and functions identically to a digital scan latch, except of course the scanned signal retains analog information. The concepts of scanning are explained using this structure, and some limitations, under experimental study at this time, are addressed. Techniques to apply this structure to continuous-time and sampled-data analog designs are described.
Oxymorphone: A mature molecule with new life (2008)

The undertreatment of acute and chronic pain continues to be a significant health concern in the U.S. Opioids are recommended for the treatment of acute or chronic pain of moderate to severe intensity that is not responsive to other pharmacologic agents, such as nonsteroidal antiinflammatory drugs. A high level of interindividual responses to the analgesic effects and side effects of opioids necessitates the availability of multiple treatment options. Extended-release and immediate-release oral formulations of oxymorphone hydrochloride were recently approved by the U.S. Food and Drug Administration and may provide new options for patients who have not achieved adequate and well-tolerated analgesia with their current opioid. This review provides an overview of the basic pharmacology (including pharmacokinetic and pharmacodynamic profiles), clinical efficacy and tolerability of both oral oxymorphone formulations.
Microcomputer control algorithms for weapon pointing and stabilization (1981)

Since late 1978. technology efforts have been underway within the Fire Control and Small Caliber Weapon Systems Laboratory. Dover. NJ. to exploit state-of-the-art advances in modern control theory and microprocessors for weapon pointing and stabilization. Results to date have been quite encouraging and serve to emphasize the importance of these two emerging technologies in the design of future high performance armament systems. This paper describes the discrete-time regulator microprocessor algorithms which have been implemented and tested on a microcomputer-based servo control system located in the Stabilization Research Laboratory facility at ARADCOM. These algorithms include reduced-order observers for estimating system states and disturbances. and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LQ</tex> - based digital control laws for precision stabilization in the presence of external disturbances.
Characterization of Cellulose Synthesis in Plant Cells (2016)

Cellulose is the most significant structural component of plant cell wall. Cellulose, polysaccharide containing repeated unbranched β (1-4) D-glucose units, is synthesized at the plasma membrane by the cellulose synthase complex (CSC) from bacteria to plants. The CSC is involved in biosynthesis of cellulose microfibrils containing 18 cellulose synthase (CesA) proteins. Macrofibrils can be formed with side by side arrangement of microfibrils. In addition, beside CesA, various proteins like the KORRIGAN, sucrose synthase, cytoskeletal components, and COBRA-like proteins have been involved in cellulose biosynthesis. Understanding the mechanisms of cellulose biosynthesis is of great importance not only for improving wood production in economically important forest trees to mankind but also for plant development. This review article covers the current knowledge about the cellulose biosynthesis-related gene family.
Combating a Different Enemy: Proposals to Change the Culture of Sexual Assault in the Military (2010)

T]he U.S. government and its military aspire to preserve the dignity and promote the fair treatment of service members across lines of gender and military rank, an aspiration thwarted by the persistence of sexual exploitation and assault within the services."-Prof.
Treatment Options for Multiple Sclerosis: Current and Emerging Therapies (2010)

Multiple sclerosis is a chronic autoimmune disease affecting the central nervous system, more specifically, the myelin sheath covering of nerve fibers in the brain and spinal cord. This disease requires lifelong disease-modifying therapy, and all of the currently available first-line disease-modifying agents are parenteral formulations only. To date, eight drugs have entered or completed phases II and III clinical trials, four of which are oral drugs. These include five immunomodulators--cladribine, fingolimod, laquinimod, teriflunomide, and dimethyl fumarate--and three monoclonal antibodies--alemtuzumab, daclizumab, and rituximab. Although comparing these new drugs with available therapies is difficult, they do show promise as potential first-line agents for the treatment of multiple sclerosis. This marks a new frontier in the treatment of this disease, as the advent of new oral drugs will lead to increased patient compliance and contribute to longer sustained symptom-free periods and less marked disability.
And pouff go all the people (1971)

It was too vexing, the Wainscottings fretted to each other, that their daughter Fiona, so fragile, so cherished, so docile and palely asthmatic, was behaving in an out-of-character manner, keeping erratic hours and not confiding in them...
New Location-Based Authentication Techniques in the Access Management (2010)

In this paper, new space-time authentication techniques are proposed. Location-based authentication is a new direction in development of authentication techniques. At the first part advantages of location-based authentication are introduced. In the second chapter the main aspects of using user's position information are discussed, as user's mobility and user's privacy. The main part of the paper is focused on introducing of two new proposed authentication techniques. The first technique called STAT I (Space-Time Authentication Technique) uses GPS system for a position determination. The second technique (STAT II) uses proprietary communication technology IQRF for a position determination. Both newly designed authentication techniques use a pocket device described in the final section of the paper.
Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2 (2009)

FGD type 2 appears to present earlier. This may reflect the functional significance of the underlying mutations in that all MRAP mutations are nonsense or splice site mutations that result in abolition of a functional protein, whereas most of the MC2R mutations are missense mutations and give rise to proteins with some residual function. Tall stature is associated with mutations in MC2R but not in MRAP. There were no other significant clinical distinctions between the two.
Estudo da difteria na cidade do Recife. I. Nota sôbre levantamento de portadores de Corynebacterium diphtheriae no bairro dos Coelhos (1969)

De uma amostra probabilística do bairro dos Coelhos da cidade do Recife, 410 indivíduos foram examinados para verificação de portadores de difteria. Sòmente duas amostras de C. diphtheriae foram isoladas de duas crianças de 8 a 9 anos, as quais não apresentaram sintomatologia compatível com o quadro diftérico.
Basic Zeolites: Characterization and Uses in Adsorption and Catalysis (1996)

Abstract The presence of basic centers in some oxides has been recognized for a long time as being important in catalysis [1-4]. Usually both basic and acid sites exist simultaneously. The two centers may work independently or in a concerted way. For instance, in alcohol transformation, dehydration is favored on acidic sites and dehydrogenation on basic centers [3,5]. A large variety of materials are cited as having basic character. They include single-metal oxides (MgO, CaO, ZnO), supported alkali metals (Na/MgO, K/K2CO3), mixed-metal oxides (MgO-A12O3, ZnO-SiO2, MgO-TiO2), zeolites (X and Y saturated with alkaline cations of low electronegativity), hydrotalcite-type anionic clays, asbestoslike materials, carbon-supported basic catalysts, and basic organic resins.
A Hybrid Machine Learning System For Stock Market Forecasting (2008)

In this paper, we propose a hybrid machine learning system based on Genetic Algorithm (GA) and Support Vector Machines (SVM) for stock market prediction. A variety of indicators from the technical analysis field of study are used as input features. We also make use of the correlation between stock prices of different companies to forecast the price of a stock, making use of technical indicators of highly correlated stocks, not only the stock to be predicted. The genetic algorithm is used to select the set of most informative input features from among all the technical indicators. The results show that the hybrid GA-SVM system outperforms the stand alone SVM system.
빈곤가구의 경제적 안정성에 관한 연구 (2012)

빈곤가구의 경제적 안정성 확보는 매우 중요함에도 불구하고, 경제적 적정성 및 경제적 불평등성에 비해 상대적으로 관심이 적었을 뿐 아니라 이에 대한 연구 또한 거의 이루어지지 않았다. 결과적으로, 빈곤가구의 경제적 안정성 확보를 위한 정책적 노력이 다른 정책에 비해 거의 이루어지지 않았다. 따라서 본 연구는 빈곤가구의 경제적 안정성을 파악하고자, 가구유형이 가구의 단기 및 장기 경제적 안정성에 관련이 있는가와 가구유형별 가구의 단기 및 장기 경제적 안정성에 영향을 미치는 요인을 살펴보았다. 이를 위해 2008년도 한국복지패널조사 자료로 실증분석을 실시하였다. 회귀분석 결과, 가구유형은 단기 및 장기 경제적 안정성과 관련이 있는 것으로 나타났다. 그러나 사회보장 체계를 고려하였을 때, 가구유형은 단기 및 장기 경제적 안정성과 통계적으로 유의미한 관련이 없었다. 공공부조는 가구의 단기 및 장기 경제적 안정성에 부적인 영향을 미치는 반면에, 사회보험은 단기 및 장기 경제적 안정성에 정적인 영향을 미치는 것으로 나타났다. 특히, 단기 및 장기 경제적 안정성에 대한 사회보험의 정적 영향은 가구의 경제적 복지에 미치는 사회보험의 중요한 긍정적 기여를 나타내는 것으로, 가구의 단기 및 장기 경제적 안정성 확보를 위한 사회보험의 보다 더 적극적인 활용 가능성을 시사한다. 근로빈곤, 비근로빈곤 및 비빈곤 가구 모두에서, 월세의 주거형태는 단기 및 장기 경제적 안정성에 부적 영향을 미치는 것으로, 가구의 경제적 안정성 확보를 위한 주택정책의 중요성을 시사한다.
Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells (2002)

Glucagon-like peptide-1 (GLP-1) is released from intestinal L-cells in response to carbohydrate and fat in the diet. Despite the interest in GLP-1 as an antidiabetic agent, very little is known about the mechanism of stimulus-secretion coupling in L-cells. We investigated the electrophysiological events underlying glucose-induced GLP-1 release in the GLP-1-secreting cell line, GLUTag. Cells were studied using perforated-patch and standard whole-cell patch clamp recordings. GLUTag cells were largely quiescent and hyperpolarized in the absence of glucose. Increasing the glucose concentration between 0 and 20 mmol/l decreased the membrane conductance, caused membrane depolarization, and triggered the generation of action potentials. Action potentials were also triggered by tolbutamide (500 micro mol/l) and were suppressed by diazoxide (340 micro mol/l) or the metabolic inhibitor azide (3 mmol/l), suggesting an involvement of K(ATP) channels. Large tolbutamide-sensitive washout currents developed in standard whole-cell recordings, confirming the presence of K(ATP) channels. RT-PCR detected the K(ATP) channel subunits Kir6.2 and SUR1 and glucokinase. GLP-1 secretion was also stimulated by glucose over the concentration range 0-25 mmol/l and by tolbutamide. Our results suggest that glucose triggers GLP-1 release through closure of K(ATP) channels and action potential generation.
Heat Wave Driven by Nanoscale Mechanical Impact between C60 and Graphene (2012)

This paper presents a novel physical phenomenon—heat wave propagation—at the atomic scale by investigating the collision of C60 molecules with a graphene sample through molecular dynamics (MD) simulation. A correlation between mechanical wave and temperature variation has been captured at the early stage of collision to demonstrate that temperature variations behave in a wave motion, which contradicts the concept in classical continuum mechanics, whereas later temperature variations exhibit the properties of a diffusion equation. This intriguing result, called wave-diffusion duality, offers an insight into the thermomechanical coupling phenomenon of nanodevices.
POLYPHOSPHATE DETERGENTS IN MECHANICAL DISHWASHING. SOLUBILIZING ACTION OF POLYPHOSPHATES (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPOLYPHOSPHATE DETERGENTS IN MECHANICAL DISHWASHING. SOLUBILIZING ACTION OF POLYPHOSPHATESLeslie R. Bacon and Eugene G. NuttingCite this: Ind. Eng. Chem. 1952, 44, 1, 146–150Publication Date (Print):January 1, 1952Publication History Published online1 May 2002Published inissue 1 January 1952https://pubs.acs.org/doi/10.1021/ie50505a043https://doi.org/10.1021/ie50505a043research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Impact of User Behavior on Information Diffusion in D2D Communications: A Discrete Dynamical Model (2018)

This paper aims to explore the impact of user behavior on information diffusion in D2D (Device-to-Device) communications. A discrete dynamical model, which combines network metrics and user behaviors, including social relationship, user influence, and interest, is proposed and analyzed. Specifically, combined with social tie and user interest, the success rate of data dissemination between D2D users is described, and the interaction factor, user influence, and stability factor are also defined. Furthermore, the state transition process of user is depicted by a discrete-time Markov chain, and global stability analysis of the proposed model is also performed. Finally, some experiments are examined to illustrate the main results and effectiveness of the proposed model.