gebhart/patrepeval huggingface dataset:
Spatio-Temporal Modelling of Culicoides Latreille (Diptera: Ceratopogonidae) Populations on Reunion Island (Indian Ocean) (2020)

Abstract Background: Reunion Island regularly faces outbreaks of bluetongue and epizootic hemorrhagic diseases, two insect-borne orbiviral diseases of ruminants. Hematophagous midges of the genus Culicoides (Diptera: Ceratopogonidae) are the vectors of bluetongue (BTV) and epizootic hemorrhagic diseases of deer (EHDV) viruses. In a previous study, statistical models based on environmental and meteorological data were developed for the five Culicoides species present in the island to provide a better understanding of their ecology and predict their presence and abundance. The purpose of this study was to couple these statistical models with a Geographic Information System (GIS) in order to produce dynamic maps of the distribution of Culicoides throughout the island. Methods: Based on meteorological data from ground weather stations and satellite-derived environmental data, the abundance of each Culicoides species was estimated for the 2,214 husbandry locations on the island for the period ranging from February 2016 to June 2018. A large-scale Culicoides sampling campaign including 100 farms was carried out in March 2018 to validate the model. Results: According to the model predictions, no husbandry location was free of Culicoides throughout the study period. The five Culicoides species were present on average in 57.0% of the husbandry locations for C. bolitinos , 40.7% for C. enderleini , 26.5% for C. grahamii , 87.1% for C. imicola and 91.8% for C. kibatiensis . The models also showed high seasonal variations in their distribution. During the validation process, predictions were acceptable for C. bolitinos , C. enderleini and C. kibatiensis , with normalized root mean square errors (NRMSE) of 15.4%, 13.6% and 16.5% respectively. The NRMSE was 27.4% for C. grahamii . For C. imicola , the NRMSE was acceptable (11.9%) considering all husbandry locations except in two specific areas, the Cirque de Salazie – an inner mountainous part of the island- and the sea edge, where the model overestimated its abundance. Conclusions: Our model provides, for the first time, an operational tool to better understand and predict the distribution of Culicoides in Reunion Island. As it predicts a wide spatial distribution of the five Culicoides species throughout the year and taking into consideration their vector competence, our results suggest that BTV and EHDV can circulate continuously on the island. It implies significant limitations for any preventive or control actions targeting vector populations. To assess other control strategies, our model could be coupled with an epidemiological model of BTV and EHDV transmission.
URINARY EXCRETION OF 17-KETOSTEROIDS IN PATIENTS WITH ADRENOGENITAL SYNDROME (1955)

The results, obtained by Wilkins et al. (1950, 1951, 1952) with cortisone, have stimulated the study of the adrenogenital syndrome during recent years. In relatively few cases, however, have details of the different fractions of the urinary 17-ketosteroids (17-KS) been reported.
Practical Colostrum Evaluation (1988)

Provision of high quality colostrum is an essential feature of a successful calf rearing program, providing immunoglobulins, non-antibody immune factors, protein, energy, fat, vitamins and minerals. A successful colostrum feeding program reduces calf mortality to less than 5%, improves resistance to enteric disease and promotes weight gain the first four days of life. Careful evaluation of several important aspects of a colostrum feeding program is essential when these goals are to be achieved.
Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2 (2014)

Histone deacetylase 2 (HDAC2) is a chromatin modifier involved in epigenetic regulation of cell cycle, apoptosis, and differentiation that is upregulated commonly in human hepatocellular carcinoma (HCC). In this study, we show that specific targeting of this HDAC isoform is sufficient to inhibit HCC progression. siRNA-mediated silencing of HDAC inhibited HCC cell growth by blocking cell-cycle progression and inducing apoptosis. These effects were associated with deregulation of HDAC-regulated genes that control cell cycle, apoptosis, and lipid metabolism, specifically, by upregulation of p27 and acetylated p53 and by downregulation of CDK6 and BCL2. We found that HDAC2 silencing in HCC cells also strongly inhibited PPARγ signaling and other regulators of glycolysis (ChREBPα and GLUT4) and lipogenesis (SREBP1C and FAS), eliciting a marked decrease in fat accumulation. Notably, systemic delivery of HDAC2 siRNA encapsulated in lipid nanoparticles was sufficient to blunt the growth of human HCC in a murine xenograft model. Our findings offer preclinical proof-of-concept for HDAC2 blockade as a systemic therapy for liver cancer.
Serum amyloid A serum concentrations and genotype do not explain low incidence of amyloidosis in Hyper-IgD syndrome (2005)

Patients with HIDS have high SAA during attacks and show sub-clinical inflammation when asymptomatic. The low incidence of amyloidosis cannot be explained by a predominance of non amyloidogenic SAA related genotypes.
Complementation of<i>Brucella abortus</i>RB51 with a Functional<i>wboA</i>Gene Results in O-Antigen Synthesis and Enhanced Vaccine Efficacy but No Change in Rough Phenotype and Attenuation (2000)

Brucella abortus RB51 is a stable rough, attenuated mutant vaccine strain derived from the virulent strain 2308. Recently, we demonstrated that the wboA gene in RB51 is disrupted by an IS711 element (R. Vemulapalli, J. R. McQuiston, G. G. Schurig, N. Srirauganathan, S. M. Halling, and S. M. Boyle, Clin. Diagn. Lab. Immunol. 6:760-764, 1999). Disruption of the wboA gene in smooth, virulent B. abortus, Brucella melitensis, and Brucella suis results in rough, attenuated mutants which fail to produce the O polysaccharide (O antigen). In this study, we explored whether the wboA gene disruption is responsible for the rough phenotype of RB51. We complemented RB51 with a functional wboA gene, and the resulting strain was designated RB51WboA. Colony and Western blot analyses indicated that RB51WboA expressed the O antigen; immunoelectron microscopy revealed that the O antigen was present in the cytoplasm. Crystal violet staining, acryflavin agglutination, and polymyxin B sensitivity studies indicated that RB51WboA had rough phenotypic characteristics similar to those of RB51. Bacterial clearance studies of BALB/c mice indicated no increase in the survival ability of RB51WboA in vivo compared to that of RB51. Vaccination of mice with live RB51WboA induced antibodies to the O antigen which were predominantly of the immunoglobulin G2a (IgG2a) and IgG3 isotypes. After in vitro stimulation of splenocytes with killed bacterial cells, quantitation of gamma interferon in the culture supernatants indicated that RB51WboA immunization induced higher levels of gamma interferon than immunization with RB51. Mice vaccinated with RB51WboA were better protected against a challenge infection with the virulent strain 2308 than those vaccinated with RB51. These studies indicate that in addition to the disruption of the wboA gene there is at least one other mutation in RB51 responsible for its rough phenotype. These studies also suggest that the expressed O antigen in RB51WboA is responsible either directly or indirectly for the observed enhancement in the T-cell response.
Mastitis Pathogens with High Virulence in a Mouse Model Produce a Distinct Cytokine Profile In Vivo (2016)

Mastitis is a serious medical condition of dairy cattle. Here, we evaluated whether the degree of virulence of mastitis pathogens in a mouse model can be linked to the inflammatory response that they provoke. Clinical isolates of <i>Staphylococcus aureus</i> (<i>S. aureus</i>) (strain 556 and 392) and <i>Escherichia coli</i> (<i>E. coli</i>) (676 and 127), and laboratory control strains [8325-4 (<i>S. aureus</i>) and MG1655 (<i>E. coli</i>)], were injected i.p. into mice, followed by the assessment of clinical scores and inflammatory parameters. As judged by clinical scoring, <i>E. coli</i> 127 exhibited the largest degree of virulence among the strains. All bacterial strains induced neutrophil recruitment. However, whereas <i>E. coli</i> 127 induced high peritoneal levels of CXCL1, G-CSF, and CCL2, strikingly lower levels of these were induced by the less virulent bacterial strains. High concentrations of these compounds were also seen in blood samples taken from animals infected with <i>E. coli</i> 127, suggesting systemic inflammation. Moreover, the levels of CXCL1 and G-CSF, both in the peritoneal fluid and in plasma, correlated with clinical score. Together, these findings suggest that highly virulent clinical mastitis isolates produce a distinct cytokine profile that shows a close correlation with the severity of the bacterial infection.
Multiple Myeloma (2014)

Abstract Multiple myeloma (MM) is a clonal accumulation of malignant plasma cells (PCs) that typically produce a monoclonal immunoglobulin (Ig) (or fragment thereof), termed M-protein, detectable in the serum or urine. Despite recent advances in its treatment (median overall survival is now 5–7 years, compared to 2–3 years for patients diagnosed 10 or more years ago), MM remains incurable. Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition in which a clonal population of plasma cells accumulates in the bone marrow (BM). MGUS is asymptomatic and does not otherwise meet diagnostic criteria for MM, but it can develop into MM, other plasma cell dyscrasia, or lymphoproliferative disease with a transformation rate of approximately 2% per year.
Streptavidin-Aequorin Fusion Protein for Bioluminescent Immunoassay (2011)

The fusion protein of streptavidin to aequorin (STA-AQ) was highly purified from inclusion bodies in Escherichia coli cells and applied to a bioluminescent sandwich immunoassay. α-Fetoprotein (AFP), which is a serological marker of liver cancer, was used as a model analyte to test STA-AQ in an immunoassay. The measurable range of AFP by the sandwich immunoassay, using the complex of STA-AQ and the biotinylated anti-AFP antibody, was 0.02-200 ng/mL with an average coefficient of variation of 4.9%. The detection sensitivity with the complex of STA-AQ and the biotinylated anti-AFP antibody was similar to that with the complex of biotinylated aequorin, streptavidin and the biotinylated anti-AFP antibody. STA-AQ would be a useful reporter protein for immunoassays.
Coding Schemes for Relay Networks (2011)

Cooperative communications by pooling available resources—for example, power and bandwidth—across the network, is a distributed solution for providing robust wireless transmission. Motivated by con ...
Micellar effects on the monohalogenation of n-pentyl phenyl ether (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicellar effects on the monohalogenation of n-pentyl phenyl etherDavid A. Jaeger and Raymond E. RobertsonCite this: J. Org. Chem. 1977, 42, 20, 3298–3301Publication Date (Print):September 1, 1977Publication History Published online1 May 2002Published inissue 1 September 1977https://pubs.acs.org/doi/10.1021/jo00440a022https://doi.org/10.1021/jo00440a022research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assessment of Mixing Performance and Power Consumption of a Novel Polymerization Reactor System (2001)

A melt-phase polymerization reactor with the novel geometry of two helical solid-tube impellers rotating within a tank, consisting of two intersecting cylinders, was designed and constructed. In order to evaluate the performance of the system, mixing times and power consumption were measured using a viscous Newtonian model fluid (glucose syrup) in place of the polymer melt. The mixing regime was laminar in all runs. The mixing time at various impeller speeds was estimated by injection of a tracer dye (crystal violet), followed by fluid sampling and visible spectrophotometric analysis. A dimensionless mixing time of km = 104 ± 36 was obtained. The power draw required to move each impeller through the fluid at various impeller speeds was measured, and a power constant of kp = 1156 ± 70 was obtained. The system appeared to outperform the conventional single helical ribbon impeller in terms of mixing time, but was less energy-efficient, as indicated by the larger power constant. The power constant value lies between values previously reported in the literature for conventional helical impellers and values reported for other types of polymerization reactors with different geometries.
Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites (2018)

Neospora caninum is one of the main causes of abortion in cattle, and recent studies have highlighted its relevance as an abortifacient in small ruminants. Vaccines or drugs for the control of neosporosis are lacking. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against several apicomplexan parasites in vitro and in laboratory animal models. We here present the pharmacokinetics, safety and efficacy of BKI-1553 in pregnant ewes and foetuses using a pregnant sheep model of N. caninum infection. BKI-1553 showed exposure in pregnant ewes with trough concentrations of approximately 4 μM, and of 1 μM in foetuses. Subcutaneous BKI-1553 administration increased rectal temperatures shortly after treatment, and resulted in dermal nodules triggering a slight monocytosis after repeated doses at short intervals. BKI-1553 treatment decreased fever in infected pregnant ewes already after two applications, resulted in a 37-50% reduction in foetal mortality, and modulated immune responses; IFNγ levels were increased early after infection and IgG levels were reduced subsequently. N. caninum was abundantly found in placental tissues; however, parasite detection in foetal brain tissue decreased from 94% in the infected/untreated group to 69-71% in the treated groups. In summary, BKI-1553 confers partial protection against abortion in a ruminant experimental model of N. caninum infection during pregnancy. In addition, reduced parasite detection, parasite load and lesions in foetal brains were observed.
Real-time Face Recognition on a Mixed SMID VLIW Architecture. (2003)

-There is a rapidly growing demand for using intelligent cameras for various applications in surveillance and identification. Most of these applications have real-time demands and require huge processing capacity. Face recognition is one of those applications highly in demand. In this paper we show that we can run face recognition in real-time by implementing the algorithm on an architecture which combines a massively parallel processor with a high performance Digital Signal Processor. In this project we focus on the INCA+ intelligent camera. It contains a CMOS sensor, a Single Instruction Multiple Data (SIMD) processor [1] and a Very Long Instruction Word (VLIW) processor. The SIMD processor enables high-performance pixel processing and detects the interesting (face) regions from the video. It sends the regions of interest to the VLIW processor, which performs the actual face recognition using a neural network. With this architecture we perform face recognition from a 5-persons database at more than 200 faces per second. The performance is better than high-end professional systems that are in use now [2]. Keywords—-Face detection; face recognition; smart camera; intelligent camera; SIMD processor; VLIW processor; real-time image processing
<title>Interferometer Design And Data Handling In A High-Vibration Environment Part I: Interferometer Design</title> (1979)

An AFGL interferometer used in airborne work is described in terms of the mechanisms utilized to counteract the influences of the harsh aircraft cabin environment. The problems of vibration are dealt with by reliance upon a command voltage-slaved balanced servo drive and Bendix Corp. Flexure Pivots for the moving mirror transport system. A piezoelectric crystal system maintains auto alignment of the stationary mirror thereby countering the warping effects that arise from aircraft cabin temperature fluctuations. The entire interferometer is further isolated from vibration by suspending it within an outer case on Aeroflex Corp. flexible cable mounts. The result is an instrument that delivers highly accurate and reliable data.
The analysis and design of architecture systems for speech recognition on modern handheld-computing devices (2003)

Growing demand for high performance in embedded systems is creating new opportunities to use speech recognition systems traditionally executed only on high performance systems. In several ways, the needs of embedded computing differ from those of more traditional general-purpose systems. Embedded systems have more stringent constraints on cost and power consumption that lead to design bottlenecks for many computationally-intensive applications. This paper characterizes the speech recognition process on hand-held mobile devices and evaluates the use of modern architecture features and compiler techniques for performing real-time speech recognition. We evaluate the University of Colorado Sonic speech recognition software on the IMPACT architectural simulator and compiler framework. Experimental results show that by using a strategic set of compiler optimization, a 500MHz processor with moderate levels of instruction-level parallelism and cache resources can meet the real-time computing and power constraints of an advanced speech recognition application.
Qualitative Effect of Fenofibrate and Quantitative Effect of Atorvastatin on LDL Profile in Combined Hyperlipidemia with dense LDL (2004)

Atorvastatin decreased all LDL-subfractions to a similar extent (quantitative effect) whereas fenofibrate reduced predominantly dLDL and changed the LDL profile towards medium dense LDL-particles (qualitative effect). Since medium dense LDL have a higher affinity to the LDL-receptor fenofibrate may have a higher antiatherogenic potential than assessed by the reduction of total LDL-cholesterol and triglycerides alone.
Cerebrospinal fluid viral load and biomarkers of neuronal and glial cells in Ramsay Hunt syndrome (2016)

Reactivation of varicella zoster virus (VZV) can manifest with facial palsy diagnosed as Ramsay Hunt Syndrome (RHS) or Ramsay Hunt Syndrome zoster sine herpete (RHS-ZSH). These syndromes are associated with poor prognosis despite treatment with antivirals and corticosteroids. Concentrations of biomarkers such as neurofilament protein (NFL), S-100β protein and glial fibrillary acidic protein (GFAp) have previously been measured in cerebrospinal fluid (CSF) to assess neuronal damage and glial pathology. We employed immunochemical methods to measure concentrations of NFL, S-100β protein and GFAp in CSF from patients with RHS (n = 15) and RHS-ZSH (n = 13) diagnosed by detection of VZV DNA in the CSF by quantitative PCR, and compared with a control group (n = 52). The biomarker concentrations were correlated with CSF viral load and outcome measured by House-Brackmann score. NFL and GFAp concentrations were increased compared with controls (P = 0.008 and P = 0.04), while S-100β levels were decreased. This pattern was more pronounced in patients with RHS compared to the patients with RHS-ZSH (NS and P = 0.028). The amount of viral DNA in CSF correlated with increased GFAp (P = 0.003) and NFL (P = 0.006). No correlations were found between biomarker concentrations and patient outcome. Patients with facial palsy caused by VZV had biochemical signs of neuronal damage and astrogliosis. High amounts of viral DNA may be associated with the degree of damage on neuronal and astroglial cells. Prospective studies are warranted to elucidate the association of elevated biomarkers in the CSF and outcome assessed by more sensitive tests.
A VLSI systolic array architecture for computation of third-order cumulants for two-dimensional signals (2002)

Cumulants or higher-order statistics have been established as powerful analytical tools in modern signal processing. To estimate cumulants directly from the incoming time-series data in real-time, it is necessary to design a parallel architecture that speeds up the estimation process. This paper describes an efficient VLSI systolic array architecture for computing third-order cumulants for two-dimensional signals. The cumulants estimation algorithm is first reformulated so that any redundancy due to symmetry properties is eliminated. The architecture exploits parallelism, pipelining, and regular cell structures. The architecture, designed with 1.0 /spl mu/ CMOS process, is capable of operating at a speed of 13 MHz. Performance results, in terms of speedup and efficiency, are presented.
Reaction between Maleic Anhydride and the Isomers of Piperylene (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction between Maleic Anhydride and the Isomers of PiperyleneRichard F. Robey, Charles E. Morrell, and Herbert K. WieseCite this: J. Am. Chem. Soc. 1941, 63, 2, 627–628Publication Date (Print):February 1, 1941Publication History Published online1 May 2002Published inissue 1 February 1941https://doi.org/10.1021/ja01847a509RIGHTS & PERMISSIONSArticle Views69Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (224 KB) Get e-Alerts Get e-Alerts