gebhart/patrepeval huggingface dataset:
Regulation of corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells (2005)

Corticotropin-releasing hormone (CRH) is secreted under stress and regulates the hypothalamic-pituitary-adrenal (HPA) axis; it is also secreted outside the brain where it exerts proinflammatory effects, possibly through mast cell activation. Mast cells are necessary for allergic reactions, but are increasingly implicated in acquired immunity and inflammatory diseases worsened by stress. Acute stress and intradermal CRH induced murine skin mast cell activation and increased vascular permeability that was absent in W/W(v) mast cell deficient mice. The presence of functional CRH receptors (CRH-R) was recently reported on human mast cells. Here, we studied the expression of CRH-R1 and CRH-R2 by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescent immunocytochemistry in human umbilical cord blood-derived cultured mast cells (hCBMCs) treated with Interleukin (IL)-1, IL-4 or lipopolysaccharide (LPS). Ten week-old hCBMCs cultured in the presence of Stem cell factor (SCF) and IL-6 were positive for both CRH-R1 and CRH-R2. However, the expression of only CRH-R2 mRNA and protein was induced by priming hCBMCs with IL-4 for the last three weeks of culture. Further analysis of the CR-H R2 mRNA expression showed that addition of IL-1 or LPS for 6 h increased only CRH-R2 gene expression. CRH had negligible effect on IL-6 secretion from non-primed hCBMCs, but induced release from IL-4 primed cells. Interestingly, LPS alone increased IL-6 release in non-primed cells, but lost this effect in primed cells. These results further implicate mast cells and CRH in either initiating or potentiating inflammatory diseases, especially those affected by stress.
Surgical Treatment of Muscular Subaortic Stenosis (1967)

The results of surgical treatment of 26 patients with muscular subaortic stenosis are presented. Left ventricular septectomy was performed in 16 patients, and septal myocardiectomy via a right ventriculotomy was employed in the last ten patients. There were five hospital deaths among these patients, yielding a mortality rate of 19%. Hemodynamic studies after operation in six patients showed relief of functional left ventricular outflow obstruction in all but one patient. This patient subsequently underwent successful right ventricular septectomy. Recently we have employed a right ventriculotomy for excision of septal myocardium during digital exploration of the left ventricular outflow tract. Freedom from serious complications and effectiveness in relieving the subaortic stenosis recommend this technique for patients with obstructive cardiomyopathy.
New concepts for millimetre wave optical links (1996)

New opto-electronic components (namely a bi-electrode laser and a multimode waveguide PIN photodiode) have been realised to open the millimetre wave frequencies to lightwave. Preliminary results on the laser show a cut-off frequency of 27 GHz which is better than the best mono-electrode laser, while the photodiode has a responsivity of around 0.5 A/W with a 3 dB bandwidth greater than 60 GHz, far away from the more conventional surface illuminated PIN photodiode.
The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover (2009)

We found only a small effect of oestrogen deprivation on cartilage. It was detected by CTX-II, but not by other type II collagen turnover markers typically affected in osteoarthritis.
Agent-oriented context-aware platforms supporting communities of practice in health care (2005)

This paper presents and discusses the use of an agent-oriented context-aware platform to support communities of practice (CoPs) in the health care domain. Our work is based on a scenario where CoPs are applied in a hospital to enhance the knowledge sharing among the staff members who share interests and goals. Here, we test the support of an agent-oriented modeling language (AORML) for the analysis of the proposed application for the test case scenario.
Aneurysmal dilation of a pericardial patch prepared with glutharaldehyde and used for closure of a ventricular septal defect. (2001)

Pericardium patches are commonly used for the repair of congenital heart diseases. Aneurysmal dilation is a complication specific to the use of pericardial patches. Preparation of the pericardium with glutharaldehyde is considered to avoid this risk. In the present case report, we describe the development of a giant aneurysm of a heterologous patch used for closure of a ventricular septal defect in a child aged 14 days.
Region Enhanced Scale-Invariant Saliency Detection (2006)

Saliency measures the low-level stimuli to human vision, and serves as an alternative to semantic image understanding. This paper presents a region enhanced scale-invariant saliency detection method. Our method constructs a scale-invariant saliency map from an image, segments the image into regions, and enhances the saliency map with the region information. Compared with previous methods, our method has advantages in providing robust scale-invariant saliency, giving meaningful region information for applications, and eliminating misleading high-contrast edges
Structures in Polar Rain Auroras (2015)

Variations in polar rain electrons observed at low altitudes (e.g., ionosphere altitudes) carry important information of the physical processes on the magnetopause and tail reconnection. Polar rain electrons often show a nightside gap and energy dispersion due to magnetotail reconnection. Simulations confirm that the energy dispersion can be used to estimate the tail reconnection position. Observations of polar rain electrons and polar rain auroras (PRA) provide a unique way for remote sensing of solar wind electrons, processes on the magnetopause, and the magnetotail reconnection location. This chapter reviews the features in the polar rain electron and aurora. The features include: the observed PRAs in the polar cap were caused by intense keV polar rain electrons; and the PRAs develop structures under high solar wind speed and southward IMF but no similar spatial structures were found in coincident superthermal electrons of the solar wind.
<title>Fiber sensing with interconnection in volume holograms through random phase encoding</title> (2000)

An all-optical fiber sensing system with interconnection in volume holograms through random phase encoding has been demonstrated. The random phase is generated from the speckles of a multi-mode fiber. The experimental and stimulation results are also presented.
Endoscopic image-guided odontoidectomy for decompression of basilar invagination via a standard anterior cervical approach (2007)

Symptomatic irreducible basilar invagination has traditionally been approached through a transoral-transpharyngeal route with resection of the anterior portion of C-1 and the odontoid. Modification of this exposure with either a Le Fort osteotomy or a transmandibular osteotomy and circumglossal approach has increased the access to pathological conditions in this region. These traditional routes all require traversing the oral cavity and accepting the associated potential complications. The authors have developed a novel surgical approach, an endoscopic transcervical odontoidectomy, which allows access for resection of the odontoid and for brainstem and spinal cord decompression without traversing the oral cavity. In this paper they describe the technique and its advantages and present three cases in which patients underwent the endoscopic transcervical odontoidectomy for basilar invagination. Three consecutive patients (age range 42-74 years) who had irreducible basilar invagination underwent the endoscopic transcervical odontoidectomy. All were symptomatic and had neck pain and myelopathy. All were evaluated preoperatively and postoperatively with computed tomography and magnetic resonance imaging. In all cases the procedure resulted in complete decompression. There were no serious complications. No patient required prolonged intubation, tracheostomy, or enteral tube feeding. One patient had an intraoperative cerebrospinal fluid leak, which had no postoperative sequelae. The authors present an alternative surgical approach for treating ventral compression of the brainstem and spinal cord. The technique is safe and effective for decompression and provides a surgical route that can be added to the armamentarium of treatments for pathological conditions in this region.
Modulation of AP‐1/ATF transcription factor activity by the adenovirus‐e1a oncogene products (1995)

The proteins encoded by early region 1 A (E1A) of human adenoviruses (Ad) modulate the expression of both adenovirus genes and various host cell genes. With these transcription-regulating properties the E1A proteins redirect the cell's metabolism, which enables them to induce oncogenic transformation in rodent cells. The E1A proteins modulate transcription by interacting both with gene-specific and general cellular transcription factors. Various members of the AP-1 and ATF/CREB families of transcription factors are targets for E1A-dependent regulation, including cJun, the protein product of the c-jun proto-oncogene. The E1A proteins modulate cJun-dependent transcription both positively and negatively, and affect the activity as well as the expression levels of cJun. By increasing the phosphorylation status of cJun, E1A can stimulate transcription regulated by cJun/ATF2 heterodimers. In contrast, E1A inhibits the expression of various metalloproteases by interfering with the DNA-binding capacity of cJun/cJun and cJun/cFos dimers, which might involve the association of E1A with the putative transcriptional coactivator p300. Since the ability of E1A to alter cJun-dependent transcription correlates with its transforming capacity, interference with cJun-dependent transcription may be an essential step in E1A-induced transformation.
<title>Application of augmented reality to visualizing anatomical airways</title> (2002)

Visualizing information in three dimensions provides an increased understanding of the data presented. Furthermore, the ability to manipulate or interact with data visualized in three dimensions is superior. Within the medical community, augmented reality is being used for interactive, three-dimensional (3D) visualization. This type of visualization, which enhances the real world with computer generated information, requires a display device, a computer to generate the 3D data, and a system to track the user. In addition to these requirements, however, the hardware must be properly integrated to insure correct visualization. To this end, we present components of an integrated augmented reality system consisting of a novel head-mounted projective display, a Linux-based PC, and a commercially available optical tracking system. We demonstrate the system with the visualization of anatomical airways superimposed on a human patient simulator.
Measurement of Ca<sup>2+</sup> Entry Using <sup>45</sup>Ca<sup>2+</sup> (2003)

For decades, the measurement of extracellular Ca2+(40Cao 2+) entry into cells, using 45Ca2+ as carrier, has been a widely used technique. One of the first studies was performed by Hodgkin and Keynes (1) to measure the rate at which 40Ca2+ labeled with 45Ca2+ crosses the surface membrane of resting squid axons, or during nervous activity. In a few large excitable cells, it was also possible to measure Ca2+ entry indirectly through the measurement of inward currents through Ca2+ channels under voltage-clamp conditions (2); however, Cao 2+ entry into small excitable cells could only be measured using 45Ca2+. With the improvement of patch-clamp techniques (3), Cao 2+ entry was measured via the analysis of single-channel or whole-cell inward currents through Ca2+ channels. The first detailed study of Ca2+ channel currents in small mammalian excitable cells was performed in 1982 (4) in bovine adrenal medullary chromaffin cells, in the laboratory of Erwin Neher, where patch-clamp methodologies were developed. As patch-clamp techniques evolved, it seemed that the measurement of Cao 2+ entry using 45Ca2+ would no longer be useful. Isotopes and scintillation fluids are expensive, administrative controls for good laboratory practices are always increasing, and the manipulation of isotopes becomes a growing nuisance. On the other hand, the time resolution of techniques using 45Ca2+ entry are in the range of seconds, whereas the patch-clamp measurement of inward Ca2+ currents is in the range of milliseconds, three orders of magnitude lower.
The globule-coil transition in a mean field approach (2006)

In this paper we study the unfolding transition observed in polymer stretching experiments. We use a known model and extend it with a mean-field-like interaction. Expressions for all necessary thermodynamic variables as a function of the model parameters are derived in closed form. To obtain the exact force-extension relation at constant temperature, we invert these relations numerically. Below a critical temperature the model exhibits a sharp first order phase transition.
Thermal collection of aerosol particles on larger liquid droplets (1976)

A mathematical model is presented to predict the collision cross section for aerosol particles on much larger cooler liquid droplets, under the restriction of small Reynolds number. The model includes consideration of inertial, viscous, and thermal forces and is valid for particles of arbitrary Knudsen number. The results are presented in terms of a collection efficiency, defined as the ratio of the collision cross section to the cross section of the droplet.
Maximum likelihood localization estimation based on received signal strength (2010)

This paper discusses a maximum likelihood (ML) estimator for the localization of mobile nodes in communication networks. The derived estimator is optimized for ranging measurements exploiting the received signal strength (RSS). For this purpose, the bias and uncertainties of the RSS based ranging procedure are analyzed, considering a path loss model of an indoor ultra-wideband (UWB) network under line of sight (LOS) conditions. The nonlinearity of the path loss model is first taken into account before the statistics of the observed RSS are approximated by a Taylor sequence of first order. The so found metrics describe a weighted least squares (WLS) method. The metrics of the estimator are analytically derived in closed-form. The performance of the derived estimator is investigated in Monte-Carlo simulations and compared with a simple least squares (LS) method and another method exploiting RSS fingerprints.
Michael Roger and John Tosh, editors. Manful Assertions: Masculinities in Britain since 1800. New York: Routledge, Chapman & Hall. 1991. Pp. x, 221. $55.00 cloth, $ 15.95 paper. (1993)

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Enhanced etch rates of tri-level resist stacks in microwave discharges (1993)

Thick (<or=4 mu m) tri-level resist schemes are increasingly common in processing of III-V devices such as heterojunction bipolar transistors (HBTS). Under the type of low-pressure, low-bias dry etching conditions necessary during processing of these damage-sensitive devices, conventional reactive ion etching produces impractically low etch rates. These etch rates can be substantially enhanced (sixfold) at the same pressure and bias by employing a hybrid microwave (2.45 GHz)-RF (13.56 MHz) reactor, which separates the control of the plasma density and the ion energies. Examples are given of the anisotropic etching of a tri-level resist scheme containing a PECVD SiNx transfer layer and a thick resist base layer, a typical scheme used in the processing of self-aligned HBTS.
Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid (1990)

The concentration of endothelin-1 (ET-1) in plasma and amniotic fluid from normal pregnant women was determined by a sensitive sandwich-enzyme immunoassay system, established recently. The plasma ET-1 level increased gradually during normal pregnancy as the pregnancy advanced, the levels (0.40 +/- 0.02 pmol/l, n = 45) being significantly (p less than 0.05) higher after 29 weeks of gestation than those (0.32 +/- 0.01 pmol/l, n = 30) before 28 weeks of gestation. The plasma ET-1 level during labor pain was significantly higher (0.59 +/- 0.06 pmol/l, n = 10) than that (0.40 +/- 0.02 pmol/l, n = 45) in the 3rd trimester of pregnancy without labor pain (p less than 0.02). Moreover, a high level of ET-1 (17.38 +/- 0.25 pmol/l, n = 18) was detected in amniotic fluid on term delivery. The ET-1 level in amniotic fluid was significantly higher than the levels in maternal and umbilical cord plasma (p less than 0.001 and p less than 0.001, respectively). After delivery the maternal ET-1 level decreased gradually and 2 day postpartum ET-1 levels reached the normal non-pregnant level.
A phase II study of talazoparib (BMN 673) in patients with homologous recombination repair deficiency (HRRD) positive stage IV squamous cell lung cancer (Lung-MAP Sub-Study, S1400G). (2019)

9022 Background: This signal finding study was designed to evaluate the clinical efficacy of a PARP inhibitor, talazoparib, in advanced stage squamous cell lung cancer harboring HRRD. Methods: Eligible patients (pts) identified through the parent S1400 screening platform were required to have a deleterious mutation in any of the study-defined HRR genes [ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCF, FANCM, NBN (NBS1), PALB2, RAD51, RAD51B (RAD51L1), RAD54L, RPA1) defined as the full eligible population (FEP). The primary analysis population (PAP) is defined by a subset of genes [ATM, ATR, BRCA1, BRCA2, PALB2]. Pts have platinum sensitive disease (at least stable disease on platinum doublet) and progressed on most recent line of systemic therapy, a Zubrod performance status of 0-1, adequate organ function, and not have been previously exposed to a PARP inhibitor and not be on systemic therapy within 21 days of registration. A 2-stage design with exact 93% power and 1-sided 0.07 level type I error required enrollment of 40 patients in the PAP in order to rule out an ORR of 15% or less if the true ORR is 35% or greater. At least 3 or more responses were needed in the first 20 pts in order to proceed to full enrolment of 40 pts in the PAP. The total accrual goal was 60 FEP assuming 67% of patients would be in the PAP. Results: The study enrolled 51 patients of whom 47 are eligible and analyzable for response (FEP) with 24 in the PAP. In the FEP, median age 66.7 yrs; M/F 39/8 (83/17%); 85% White and 15% Black; 77% of the pts received at least 1 prior line of treatment for stage IV. The study was closed for futility with only one response in the PAP. In the PAP (n = 24, median age 68 yrs), ORR was 4% (95%CI: 0, 21) and DCR was 54% (95%CI: 33, 74); median PFS of 2.4 months (95%CI: 1.5-2.8) and median OS was 5.2 months (95%CI: 3.8-10, 7). There were five responders in the FEP with ORR of 11%; DCR of 53% and median DoR was 1.8 months (95% CI: 1.3, 4.2); median PFS was 2.5 months (95%CI: 1.6-3.0) and median OS was 5.7 months (95% CI: 4.5-8.7). The most frequent grade ≥3 adverse event in the FEP were: Anemia (14.9%), thrombocytopenia (12.8%); lymphopenia (8.5%) and nausea (6.4%). Conclusions: S1400G failed to show sufficient level of efficacy for talazoparib in a biomarker defined subset of squamous lung cancer with HRRD. There were no new safety signals and hematologic toxicities were the most frequent adverse events. Clinical trial information: NCT02154490.
Influence of Self-Reorientation Effect on Isothermal and DC Demagnetization Remanence Curves (1993)

We have calculated two types of remanence curves ( I r : isothermal remanence curve and I d : DC demagnetization curve) using a phenomenological model based on the mean field theory and the normal distribution function as the switching field. In this paper, the reorientation effect of magnetic moments due to the internal field in the absence of the external field is taken into account. The model shows that this effect plays an influential role in I r and I d curves for magnetic materials with large negative interaction coefficients.
Synthesis, photolysis, and pyrolysis of 10-substituted exo-3,4,5-triazatricyclo[5.2.1.02,6]dec-3-enes. Preparation of 8-substituted exo- and endo-3-aryl-3-azatricyclo[3.2.1.02,4]octanes (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, photolysis, and pyrolysis of 10-substituted exo-3,4,5-triazatricyclo[5.2.1.02,6]dec-3-enes. Preparation of 8-substituted exo- and endo-3-aryl-3-azatricyclo[3.2.1.02,4]octanesPaul G. Gassman and John G. SchaffhausenCite this: J. Org. Chem. 1978, 43, 16, 3214–3223Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://pubs.acs.org/doi/10.1021/jo00410a024https://doi.org/10.1021/jo00410a024research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Silver Ion Binding Energies of Amino Acids:  Use of Theory to Assess the Validity of Experimental Silver Ion Basicities Obtained from the Kinetic Method (2002)

The complexes of silver ion, Ag+, with the twenty naturally occurring amino acids have been calculated using hybrid density functional theory at the B3LYP/DZVP level. For all of these silver complexes, several possible structures were examined, but as there are remarkable similarities between all the structures at the global minima, only summarized data are reported. All of the complexes, except that with proline, are solvated ions. Amino acids containing only hydrocarbon side chains are bidentate, coordinating through the amino and carbonyl groups and the remaining amino acids (with the exception of proline) are tricoordinate with the same two interactions as in the simpler amino acids and an additional interaction through the side chain. The proline complex contains zwitterionic proline with the Ag+ ion attached to the carboxylate anion. Enthalpies (at 298 K) for dissociation of Ag+ from the complexes range from 49.3 kcal mol-1 for glycine to 80.4 kcal mol-1 for arginine. Free energies for these reactions are in the range of 40.7 kcal mol-1 for glycine to 70.3 kcal mol-1 for arginine. Comparison of the calculated free energies (relative to that of glycine) with those measured by the kinetic method shows good agreement, with the largest discrepancy being 3.9 kcal mol-1 for aspartic acid. There are some systematic trends with theory giving lower values than experiment for amino acids containing aromatic groups in the side chains (phenylalanine, tryptophan, and tyrosine) and higher values for the four amino acids with carbonyl groups in their side chains (aspartic acid, asparagine, glutamic acid, and glutamine).