gebhart/patrepeval huggingface dataset:
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha). (1990)

Retinoic acid (RA) induces terminal granulocytic differentiation of the HL-60 promyelocytic leukemia cell line as well as certain other human myeloid leukemias. Specific RA receptors that are members of the steroid-thyroid hormone superfamily of nuclear transcription factors have recently been identified. We developed an HL-60 subclone that was relatively resistant to RA-induced differentiation. Specific nuclear RA receptors in this RA-resistant subclone had a decreased affinity for RA and exhibited a lower molecular weight compared with nuclear RA receptors from the RA-sensitive parental HL-60 cells. Retroviral vector-mediated transduction of a single copy of the RA receptor (RAR-alpha) into this RA-resistant HL-60 subclone restored the sensitivity of these cells to RA. These observations indicate that RAR-alpha plays a critical and central role in mediating RA-induced terminal differentiation of HL-60 leukemia cells.
Synergistic In Vitro Interactions between Alpha Interferon and Ribavirin against Bovine Viral Diarrhea Virus and Yellow Fever Virus as Surrogate Models of Hepatitis C Virus Replication (2003)

Monotherapy of hepatitis C virus infection with either alpha interferon or ribavirin alone is rather ineffective, while the use of the two antivirals together is much more efficacious. In vitro drug-drug combination analysis utilizing related members of the family Flaviviridae, bovine viral diarrhea virus and yellow fever virus, revealed significant direct synergistic interactions between these drugs' antiviral activities that might explain this clinical observation.
Music perception and octave generalization in rhesus monkeys. (2000)

Two rhesus monkeys were tested for octave generalization in 8 experiments by transposing 6- and 7-note musical passages by an octave and requiring same or different judgments. The monkeys showed no octave generalization to random-synthetic melodies, atonal melodies, or individual notes. They did show complete octave generalization to childhood songs (e.g., "Happy Birthday") and tonal melodies (from a tonality algorithm). Octave generalization was equally strong for 2-octave transpositions but not for 0.5- or 1.5-octave transpositions of childhood songs. These results combine to show that tonal melodies form musical gestalts for monkeys, as they do for humans, and retain their identity when transposed with whole octaves so that chroma (key) is preserved. This conclusion implicates similar transduction, storage, processing, and relational memory of musical passages in monkeys and humans and has implications for nature-nurture origins of music perception.
Power efficient, bandwidth optimized and fault tolerant sensor management for IOT in Smart Home (2015)

This paper proposes a localized data processing and decision making framework for IoT enabled environment. It constitutes a master unit which efficiently manages local sensor networks in Smart Homes. This master unit collects data from the network of sensors installed in different locations within and around the house and intelligently identifies the dependencies among them. Based on this, the set of sensors are classified as dependent whose output values can be predicted using data from remaining of them. This knowledge extracted locally is shared with the Cloud Server, thereby providing a refined picture of the sensory data. On the basis of locally extracted knowledge, the sensors are tuned in real time to minimize the redundancy in usage and power consumption. Moreover, in cases of failure of a sensor unit, approximate decisions can still be made based on previous patterns.
MUTAGENIC SCREENING OF DIAMINE MONOMERS (1983)

The effects of phenyl ring coupling moieties, of isomeric amine positions relative to the coupling groups, and of insertion of other coupling groups on the mutagenic response of a series of dianilines were investigated using the Ames Salmonella assay. Generally, S-9 metabolic activation from Aroclor-induced rat liver was required for mutagenic expression. The range of mutagenicity of steric isomers of several dianiline series was also investigated. No mutagenicity was found for purified samples of o,o' and m,p' isomers of methylene dianiline (MDA) and diaminobenzophenone, while varying degrees of mutagenicity were found for other isomers. The mutagenicity of "benzylogs" of MDA decreased as the degree of linear separation of the m,m' anilino groups by aromatic rings increased. Methylation and two-year storage increased mutagenic response in certain isomers of MDA. However, high performance liquid chromatography indicated there was no discernible change in m,p'-MDA samples aged under varied conditions over four months. Likewise, no change in mutagenicity was found.
Silencing of <i>Agrobacterium tumefaciens</i> oncogenes <i>ipt</i> and <i>iaaM</i> induces resistance to crown gall disease in plum but not in apricot (2017)

RNAi-mediated gene silencing can be used for inducing crown gall resistance in plum rootstocks. These could be used to graft non-genetically modified commercial fruit cultivars reducing, or eliminating, the disease symptoms. © 2017 Society of Chemical Industry.
Prevention of Myocardial Infarction (1996)

Abstract Coronary heart disease remains the leading cause of death in both men and women in most industrialized countries. Yet it is largely preventable, and health care providers can acquire the skills to help their patients reduce their risks substantially. Traditional risk factors such as cigarette smoking, hypercholesterolimia, hypertension, sedentary lifestyle, obesity and glucose intolerance explain a major proportion of coronary events. Recent evidence also suggests important adjunctive roles for hormone replacement therapy in postmenopausal women, and aspirin prophlaxis in individuals at high risk of a first myocardial infarction. Emerging evidence indicates an important role for diet in the prevention of heart disease. Although the importance of lifestyle and behavioral modifications may well be known among physicians and other health-care providers, the implementation of this knowledge has been limited. One reason is that the information supporting the value, feasibility and cost-effectiveness of risk-reduction strategies has not been previously synthesized and made widely available to health-care providers in office and community settings. Prevention of Myocardial Infarction fills these critical gaps by providing a state-of-the-art compendium of the scientific evidence on the efficacy of coronary disease prevention, while focusing on helping clinicians develop intervention skills to utilize available knowledge. Chapters by leading authorities in cardiovascular epidemiology, clinical cardiology, cost-effectiveness analysis, and public health translate the theory of preventive cardiology into feasible implementation. The counseling and other intervention strategies described in this textbook have documented clinical efficacy and cost-effectiveness, and they require little time to learn or implement. The book is written mainly for primary care providers, including general internists and family physicians, but will also be of interest to medical subspecialties such as cardiologists and endocrinologists, as well as medical students, dietitians, psychologists, epidemiologists, and students, practitioners, and researchers in public health.
New opportunities for New SQL (2012)

The Communications Web site, http://cacm.acm.org, features more than a dozen bloggers in the BLOG@CACM community. In each issue of Communications , we publish selected posts or excerpts. twitter Follow us on Twitter at http://twitter.com/blogCACM http://cacm.acm.org/blogs/blog-cacm Michael Stonebraker expects a substantial increase in the number of New SQL engines using a variety of architectures in the near future.
Fabrication of Heavy Metal Ion FET Based Sensor for Detecting Arsenite (2020)

Arsenic is one of the toxic chemical among heavy metals. It is mostly present in ground water at higher levels which leads to cancer and heart diseases. Arsenic occurs in two oxidation states, Arsenite (As (III)) and Arsenate (As (V)). As (III) is more toxic than As (V). The detection of arsenic ion in drinking water or in any liquid form of food can be done with several laboratory equipment’s such as ICP-MS. In this research, we developed a methodology by fabricating an extended gate chip FET sensor for detecting As (III) ions. Sodium Arsenite (NaAsO 2 ) is the inorganic compound which is used for detection of As (III). The concentration range is from 10^-10 M to 10^-4 M. This sensor is easy to fabricate, smaller in size, high sensitivity and takes less time for detecting Arsenite comparable to several laboratory equipment’s. This FET based ion sensor has same detection limit comparable to ICP-MS and this sensor shows higher sensitivity than the Nernstian slope.
Study on the Energy Band Structure of La Doped ZnO (2011)

The energy bands of La -doped ZnO were studied systematically by the density functional theory (DFT). Based on the data of the band structure, DOS (Density of State) and PDOS( Partial Density of States), atomic populations and net charge, the influence on the energy band structure of the macrostructure of ZnO and La-doped ZnO was investigated. The results showed that the free electrons were produced by the doping of La on (or in) ZnO crystal. The Fermi energy was shifted up to the conduction band, making the ZnO particles having the characters of degenerated semiconductor. The excitation from impurity states to the conduction band may account for the blue shift of the absorption edge in the model of La-doped ZnO. Comparison with the different models of the La doped/loaded on the ZnO surface, La atoms loaded on the surface of ZnO and La atoms replaced of Zn atoms on the ZnO surface, the shift to the lower energy location were found after La doping/loading. The more shift and the large band gap was found for the model of La doped on the Zn position in the ZnO crystal.
Self-service kiosk for testing sunglasses (2014)

The prototype identifies the UV protection, for non-corrective sunglasses, according to category of the lens and is available for the public. In addition to educating the population about the importance of wearing protected sunglasses, the prototype has also allowed the public to have access to information about the quality of protection of their own sunglasses in an easy and free testing method.
Indoor localization and point cloud generation for building interior modeling (2013)

Indoor modeling can be defined as the study of how photorealistic 3D model can be realized by localization and mapping for describing indoor environment which is beyond 2D model while providing useful information on the location. In this paper, a 3D localization method for an IGS(Information Gathering System) is presented for the point cloud generation of building interiors. First, a backpack IGS which is worn by a human operator and gathers information on environment along hallways is introduced. Next, a travel distance of the IGS is defined, which is utilized for estimating 3D poses of IGS. Then a 3D pose estimation method for localization of the IGS is proposed based on the SLAM method composed of two kinds of 2D SLAM methods, which extract the most reliable poses from the sensors on IGS. The proposed method is evaluated on challenging data of various indoor environments, and it is shown that it effectively localizes the IGS in complex indoor spaces with staircases.
Performance Management and Evaluation: Exploring Complementarities (2013)

Abstract For some time now, evaluators have been trying to locate their work in relation to the emergence of performance management. Although some have rejected performance management outright as conceptually weak and simplistic, others have looked for complementarities between the two approaches to generating knowledge. The authors address these concerns and identify the emergence of complementarity below the broad constructs of evaluation and performance management writ large, instead seeing it as inhering in the approaches to measurement and monitoring employed by practitioners of these disciplines, respectively. This chapter elucidates performance management and the six key elements it requires: leaders, managers, accountability systems, performance budgeting, measuring and monitoring, and evaluation. It also indicates some of the major concerns evaluators have raised regarding the validity of knowledge produced within performance‐management approaches that do not rely on evaluations. © Wiley Periodicals, Inc., and the American Evaluation Association .
Comparison of Several Laboratory Media for Presumptive Identification of Enterococci and Group D Streptococci (1973)

Bile-esculin (Difco), modified bile-esculin (Difco), selective enterococcus (Pfizer Co.), and eosin-methylene blue agar media were evaluated for accuracy in identifying group D streptococci. The regular and modified bile-esculin media performed equally well, but the selective enterococcus and eosin-methylene blue agars did not accurately differentiate the group D from non-group D streptococci. A modified 6.5% NaCl broth was compared with unmodified 6.5% NaCl broth and Streptococcus faecalis (SF; Difco) broth for accuracy in differentiating enterococci from non-enterococci. The modified and unmodified broths worked equally well in the salt tolerance test, but the lot-to-lot variability of SF broth made this medium unusable as an indicator for enterococci. With all seven media, the number of strains giving positive tests decreased when the tests were incubated at 45 C as compared with 35 C, and the number of strains giving negative tests increased. Thus, the number of false-positive identifications decreased, but the number of false-negative identifications increased. Variability in the susceptibility of group D non-enterococcal streptococci to oxacillin and methicillin sensitivity disks limited the usefulness of these tests for presumptive identification of either enterococci or group D streptococci.
Interpretation of Scaling of Damage and Failure in Fiber Composite Laminates (1994)

It is often useful to predict the behavior of large structures from the results of tests on subscale articles. While the scaling of the linear elastic response of fiber com posite structures is at least reasonably well understood, scaling of damage formation and failure is relatively unexplored. Idealized models of failure processes predict various effects of changes in size. Extrapolation of failure results with size thus requires proper interpretation of the failure mechanisms involved. A series of impact tests was recently carried out in which scaling with respect to size was a primary variable. An analysis of the data from these tests indicates a number of important results with respect to the models of failure mechanisms mentioned above. A primary result is that propagation of delamination closely follows the dependence on absolute size predicted by fracture mechanics and energy release rate analyses. Conversely, fiber breakage does not appear to show a dependence on absolute size. The primary thrust of the paper is to assess the implications of the experimental results in terms of the failure models and the effect on scaling of results.
Ditch Flow Program (1983)

Seventeenth in the CE Computing BASICS series, the program in this article is for simplifying drainage calculations. The program will provide critical and normal velocities, depths and slopes, and travel time for vee, trapesoidal, rectangular and circular shaped channels. The program simplifies ditch calculations and provides input for tailwater control culvert design. Written in BASIC, the article includes a complete program printout and step-by-step instructions.
Beneficial effects of long-term beta-blockade in congestive cardiomyopathy. (1980)

Twenty-eight patients with heart failure caused by congestive cardiomyopathy, which had been diagnosed according to the criteria of Goodwin and Oakley, were treated with beta-blocking agents for six to 62 months, except for four patients who died within two months. Repeated non-invasive investigations were performed before and during treatment as well as exercise tests and chest x-rays. The echocardiographic and pulse curve findings indicated an improvement in systolic and diastolic myocardial function. The ejection fraction increased from 0.32 +/- 0.02 to 0.42 +/- 0.04, and the third heart sound amplitude and rapid filling wave were significantly reduced. The functional classification improved in 15 patients while in 12 patients it remained unchanged and in one it deteriorated. During follow-up, 10 patients died, most of them suddenly. The mortality was lower than expected in this severely ill group of patients. The beneficial effect of chronic beta-blockade in patients with congestive cardiomyopathy suggests that catecholamines are involved in the pathogenesis of congestive cardiomyopathy, and that patients with congestive cardiomyopathy may have inappropriate sympathetic cardiac stimulation which can be reduced by chronic beta-blockade. It is suggested that beta-receptor blockade should be added to conventional treatment with digitalis and diuretics in all patients with severe myocardial failure caused by congestive cardiomyopathy.
Stimulation of protein kinase C activity by tumor necrosis factor-α in bovine bronchial epithelial cells (1997)

Bronchial epithelial cell migration, attachment, and proliferation are important processes in response to airway injury. We have shown that tumor necrosis factor (TNF)-alpha stimulates the migration of bovine bronchial epithelial cells (BBEC) in vitro. We hypothesized that protein kinase C (PKC) may be one of the intracellular signaling mediators of TNF-alpha in BBEC. In this study, we have identified multiple PKC isoforms in BBEC and measured total cellular PKC activity. Polyclonal antibodies to the PKC-alpha, -beta 2, -delta, and -epsilon isoforms recognized protein bands around 80-90 kDa. BBEC primary cultures treated with either 500 U/ml TNF-alpha for 2-4 h or 100 ng/ml 12-O-tetradecanoylphorbol 13-acetate for 15 min resulted in three-to fivefold increases in PKC activity in the particulate fractions of crude cell lysates. This activity was inhibited by 1 microM calphostin C or 10 microM H-7. Similarly, TNF-alpha-stimulated BBEC migration was reduced at least twofold in the presence of H-7 or calphostin C. These studies suggest that the activation of PKC is necessary for TNF-alpha-stimulated BBEC migration.
PHENOLIC COMPONENTS OF RAPESEED MEAL (1980)

ABSTRACT The phenolic components of several rapeseed meals were studied in base hydrolyzed extracts as free acids and in 70% aqueous acetone extracts as intact compounds. Thin‐layer chromatography, gas chromatography, and mass spectroscopy were used for compound purification and identification. The free acids in the hydrolyzed extracts in order of concentration were: sinapic >> protocatechuic > ferulic > p‐hydroxybenzoic > vanillic > syringic. Sinapic acid was the only free phenolic acid detected in the 70% aqueous acetone extracts although there was at least seven other compounds that upon hydrolysis yielded Sinapic acid. Neither chlorogenic acid or caffeic acid were detected in any of the meals although they had previously been reported.
Heart-surface potentials estimated from 12-lead electrocardiograms (2010)

We investigated whether the ischemic region due to coronary-artery occlusion can be visualized on the heart-surface display by using as input data just ST measurements from the 12-lead ECG. A boundary-element torso model was used to estimate heart-surface potentials from body-surface potential maps (BSPMs) obtained from 12-lead ECG via transformation developed from a design set (n = 892) of 120-lead ECGs by a least-square solution to the linear regression problem. The test set consisted of 120-lead ECGs acquired for 45 patients during ischemia induced by balloon-inflation angioplasty; subgroups of equal size consisted of patients whose LAD, LCx, and RCA were occluded, respectively. BSPMs at J point of each patient were predicted from the 12-lead ECG and similarity of original and predicted maps was assessed by a similarity coefficient SC (0–100%). By inverse solution, heart-surface potentials were then estimated from original and predicted BSPMs and visualized on a bull's-eye display. Reconstitution of known BSPMs from the 12-lead ECG achieved an overall SC 92.46 ± 6.95% (mean ± SD); for subgroups, SC was: 89.79 ± 9.95% for LAD, 93.89 ± 2.86% for LCx, and 93.70 ± 5.77% for RCA group. Estimated heart-surface potential distributions featured an area of positive potentials corresponding, in general, to the underperfused territory caused by the occlusion. Encouraging results can be attributed to the strongly dipolar character of BSPMs caused by injury current. This approach shows promise for ischemia detection and quantitation.
Tuning and calibration in thermospray liquid chromatography/mass spectrometry using perfluorinated alkyl acids and their ammonium salts (1990)

Abstract Of the several approaches used to interface liquid chromatography with mass spectrometry, the thermospray interface has evolved as the most popular and applicable for the analysis of polar and labile organic compounds. Since a separate ion source must be used for thermospray, separate tuning and calibration are required. Unfortunately, current approaches to tuning and calibration suffer from serious shortcomings, most notably rapid contamination of the ion source. Recent reports have shown that this shortcoming can be overcome by using acetic acid‐ammonia cluster ions or trifluoroacetic acid–ammonia cluster ions for tuning and calibration. In the latter approach, the tuning solution could also be used in the negative ion mode of operation but suffers from concentration of most of the ion current in one ion. The use of perfluorinated alkyl acids and their ammonium salts to generate intense high‐mass negative ions for tuning and calibration to m/z 2000 is reported. Additionally, the ammonium salts of the longer chain perfluorinated acids offer an enhanced high‐mass response in the positive ion mode of operation.
OPPORTUNISTIC PATHOGENS IN THE GENUS <i>MYCOBACTERIUM</i> (1985)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More
Effect of 72 Hz pulsed magnetic field exposure on macromolecular synthesis in CCRF-CEM cells. (1991)

Cells from the T-lymphoblastoid cell line, CCRF-CEM, have been exposed in vitro to a quasirectangular, asymmetric electromagnetic field pulsed at 72 Hz at 37 degrees for periods of 30 min to 24 h. RNA synthesis, assessed by incorporation of 3H-uridine, increased (relative to control cells) 2-fold after 30 min in exposed cells and achieved its greatest increase of 3.2-fold relative to controls after 2 h exposure. Increased precursor incorporation was observed at all subsequent exposure times up to 24 h. Synthesis of mRNA was similar, but not identical to that observed with total cellular RNA. Additionally, protein synthesis, determined by incorporation of radioactive precursor into acid-precipitable material, was increased 2.8-fold, compared to controls, after 2 h exposure. Longer exposure times resulted in an exponential decrease in precursor incorporation to 1.1-times control levels after 24 h. Using a dye reduction assay, mitochondrial activity was also found to be increased over a 24 h exposure period. No effect of electromagnetic field exposure was found on cellular synthesis of DNA. These data are generally consistent with other reports documenting effects of electromagnetic field exposure on macromolecular synthesis in vitro.