gebhart/patrepeval huggingface dataset:
Electronic tongue based on porphyrins for Apulian red wines defects detection (2017)

Electronic tongue based on porphyrin coatings obtained by electrochemical polymerization process was employed for the detection of Apulian wines (Primitivo and Negroamaro) defects related to the presence of “off-odor” methiol (3-(methylthio)-propanol) and ethyl phenol compounds, isoamyl alcohol fusel oil, the marker of the yeast activity benzaldehyde and vinegar formation marker acetic acid. The satisfactory prediction with R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> 0.989 and 0.732 for isoamyl alcohol and acetic acid were obtained for in real wine samples. Moreover, the possibility to distinguish wine samples on the base of permitted levels of fault compounds content was shown.
Efficacy of cardiorespiratory aerobic exercise in rheumatoid arthritis: Meta‐analysis of randomized controlled trials (2010)

Cardiorespiratory aerobic conditioning in stable RA appears to be safe and improves some of the most important outcome measures. However, the degree of the effect of aerobic exercise on the abovementioned parameters is small.
<i>In vitro</i> -generated neural precursors participate in mammalian brain development (1997)

During embryogenesis, pluripotent stem cells segregate into daughter lineages of progressively restricted developmental potential. In vitro, this process has been mimicked by the controlled differentiation of embryonic stem cells into neural precursors. To explore the developmental potential of these cell-culture-derived precursors in vivo, we have implanted them into the ventricles of embryonic rats. The transplanted cells formed intraventricular neuroepithelial structures and migrated in large numbers into the brain tissue. Embryonic-stem-cell-derived neurons, astrocytes, and oligodendrocytes incorporated into telencephalic, diencephalic, and mesencephalic regions and assumed phenotypes indistinguishable from neighboring host cells. These observations indicate that entirely in vitro-generated neural precursors are able to respond to environmental signals guiding cell migration and differentiation and have the potential to reconstitute neuronal and glial lineages in the central nervous system.
Two Dimensional Optical Phased Array System (1990)

An integrated two-dimensional array of coherent emitters has been constructed from AlGaAs GRaded INdex Separate Confinement Heterostructure - Single Quantum Well (GRIN-SCH-SQW) material. The linear active integrated optic array contains: a Y-branch network to divide input optical power from one to ten branches, individual phase modulators and separate traveling-wave amplifiers for each of ten channels. The two-dimensional array is formed from two linear arrays which simulate a two-dimensional stack of linear arrays through the used of a beam combiner. The combiner overlaps the two arrays to produce a simulated 2-D array with an emitter spacing of 1.0 mm x 1.0 mm.
Hydrophobicity Engineering to Increase Solubility and Stability of a Recombinant Protein from Respiratory Syncytial Virus (1995)

Site-directed mutagenesis has been employed to engineer the hydrophobic properties of a 101-amino-acid fragment from the human respiratory syncytial virus (RSV) major glycoprotein (G protein). When this protein was produced in Escherichia coli, more than 70% of the gene product was found as inclusion bodies, and the product recovered from the soluble fraction was severely degraded. Substitution of two cysteine residues for serine residues, did not significantly change the solubility or stability of the gene product. In contrast, a dramatic increase in both solubility and stability was achieved by multiple engineering of hydrophobic phenylalanine residues. As compared to the non-engineered protein, the fraction of soluble protein in vivo could be increased from 27% to 75%. Surprisingly, this effect was accompanied by a remarkable increase in stability. The in vitro solubility of the purified gene products was similarly increased approximately fivefold. Structural studies using circular dichroism suggest that the two engineered fragments have a distribution of secondary-structure elements similar to the non-engineered fragment. In addition, the two engineered G-protein variants were demonstrated to be at least in part antigenically authentic to the non-engineered gene product. These results demonstrate that engineering of hydrophobic residues can be used as a tool to increase the solubility and proteolytic stability of poorly soluble and labile proteins.
The stereospecific loss of water from 1,4‐dihydroxy‐Δ<sup>6,7</sup>‐octalins under electron impact (1977)

Abstract The mass spectra of four of the six 1,4‐dihydroxy‐ Δ 6,7 ‐octalins are reported. The spectra differ considerably, depending on the configuration of the hydroxyl groups. The relative amounts of 1‐3,1‐4, transannular 1‐3 and hydroxyl‐hydroxyl elimination of water from the molecular ions were determined by using specificaliy labelled compounds. Effects of configuration and conformation are discussed.
Physiochemical Measurements of Metal Chelates by Gas-Liquid Partition Chromatography (1968)

Journal Article Physiochemical Measurements of Metal Chelates by Gas-Liquid Partition Chromatography Get access D. R. Gere, D. R. Gere Search for other works by this author on: Oxford Academic PubMed Google Scholar R. W. Moshier R. W. Moshier Aerospace Research Laboratories, Wright-Patterson AFB, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Chromatographic Science, Volume 6, Issue 2, February 1968, Pages 89–94, https://doi.org/10.1093/chromsci/6.2.89 Published: 01 February 1968 Article history Received: 08 December 1966 Revision received: 05 June 1967 Published: 01 February 1968
Lutein - An Opportunity For Improved Eye Health (2001)

* Correspondence: Stuart Richer, OD, PhD, FAAO Chief, OptometryEye Clinic/Operative and Invasive Procedures DVA Medical Center, North Chicago, IL 60064 Phone: (847) 688-1900 ext. 85406 Fax: (847) 578-6924 E-mail: Stuart.Richer@Med.VA.Gov Dr. Andrew Shao is among few scientists, and even fewer clinicians, who appreciate the weight of evidence and emerging potential for improved eye health and vision in the aging industrialized population centers of the world. In his article: The Role of Lutein in Human Health, Dr. Shao devotes his review to a neglected dihydroxy carotenoid that plays both preventative and therapeutic roles in optimizing eye health. Lutein as well, shows early promise in cardiovascular health and myriad cancers.
Characterization of a Quantum Cascade Laser Based Emissivity Monitor for CORSAIR (2011)

The QCL based emissivity monitor which was designed to obtain emissivity uncertainty goal of ±0.00015 (3σ) for the CORSAIR blackbody has been characterized. The laser power stability and temperature distribution of the system are analyzed.
Construcción de una central hidroeléctrica al pie de la presa de San Rafael, México (2017)

La cuenca del rio Santiago en Mexico esta regulada por una sucesion
de presas y embalses caracterizados por la enorme magnitud de los
caudales a regular. Todas sus infraestructuras son ejemplos de retos
ingenieriles. Aguas abajo de todas ellas, hace ya mas de veinte anos se
construyo un embalse de regulacion, San Rafael, el cual se dejo previsto
para la instalacion de una futura central hidroelectrica a pie de
presa.
Fueron numerosos los intentos por desarrollar el proyecto de la
central a pie de presa, pero la complejidad tecnica del mismo provoco
que durante mas de cuatro lustros no se llevase a cabo este proyecto.
Finalmente en el ano 2012, Acciona Ingenieria comenzo la redaccion
de este proyecto, para posteriormente continuar desarrollando los
trabajos correspondientes a la asistencia tecnica a la obra, encontrandose
a dia de hoy ya la central terminada completamente y por lo
tanto en fase de explotacion a pleno rendimiento.
Los principales retos del proyecto y de la construccion se enumeran
a continuacion:
• Construccion de una central hidroelectrica al pie de una presa existente
y en carga, sin reduccion de los niveles de embalse, algunos
de los cuales llegaron a alcanzar magnitud de niveles extraordinarios
durante la construccion.
• Realizacion de un vaciado para la construccion de la central, de veinte
metros de altura, el cual se situa quince metros bajo la cota de
cimentacion de los bloques de presa afectados.
• Ejecucion confinada en el estribo, entre una ladera escarpada y la
propia presa, que obligaba a un fuerte sostenimiento de las ya complicadas
excavaciones con presencia de agua.
• En el bloque de toma existente, hubo que realizar labores de anclaje,
control de filtraciones, inyecciones de impermeabilizacion y un
estudio de las distintas familias de fallas al objeto de asegurar su
estabilidad una vez abierta la excavacion y con la presa en carga.
• Accion sismica de diseno muy fuerte, con la consecuente repercusion
en el diseno de diferentes elementos estructurales.
• Para ajustar el proceso constructivos a los plazos establecidos por
el cliente fue necesario modificar el planteamiento inicialmente
previsto, con el ajuste de los elementos estructurales que lo requirieron,
para asi poder desarrollar simultaneamente los trabajos de
construccion de las camaras espirales de las turbinas Kaplan, con
las tareas de ejecucion de los muros perimetrales, asi como de la
estructura metalica que serviria de soporte al puente grua necesario
para poder montar los generadores.
DIARYL TELLURIDES FROM THE REACTION OF MODERATELY ACTIVATED IODOARENES WITH BENZENETELLUROLATE ION IN HEXAMETHYLPHOSPHORIC TRIAMIDE (1981)

Abstract When heated in hexamethylphosphoric triamide at 80–90°C, preferably in the presence of copper(I) iodide, moderately activated iodoarenes undergo nucleophilic attack by benzenetellurolate ion, giving the corresponding unsymmetrical diaryl tellurides in fair to good yields.
Hazardous gas handling in semiconductor processing (1990)

A variety of hazardous gas reactants are used in the production of semiconductor devices. Silane is an example of a highly flammable and explosive gas. Even dilute mixtures of 3% silane in an inert carrier gas are self-igniting in air. Arsine and phosphine are highly toxic gases while HC1 is widely recognized for its corrosive nature. This paper describes a generalized approach to handling hazardous gases which can be modified to meet the requirements of any specific application. The concept is based on a system design that all but eliminates the possibility of large leaks while providing the means to adequately dilute the modest spillages that may occur. Normal quantities of reactants used in the process are handled so as to maintain their purity and problems such as silane explosions in the mechanical pumps are avoided.
Comparison study of Trilateral Rankine Cycle, Organic Flash Cycle and basic Organic Rankine Cycle for low grade heat recovery (2017)

Organic Rankine Cycle (ORC) has been widely used for the recovery of low-grade heat into power such as solar energy and industrial waste heat. The overall thermal efficiency of ORC is affected by large exergy destruction in the evaporator due to the temperature mismatching between the heat source and working fluid. Trilateral Cycle (TLC) and Organic Flash Cycle (OFC) have been recognized as potential solutions because of their better performance on temperature matching between the heat source and working fluid at the evaporator. In this study, thermodynamic models of above three cycles are established in MATLAB/REFPROP. Results indicate that TLC obtains the largest net power output, thermal efficiency and exergy efficiency of 13.6 kW, 14.8% and 40.8% respectively at the evaporation temperature of 152℃, which is 37% higher than that of BORC (9.9 kW) and 58% higher than that of OFC (8.6 kW). BORC is more suitable under the conditions low evaporation temperature is relatively low due to the achieved maximum net power output, thermal efficiency and exergy efficiency. OFC has the minimum net power output, thermal efficiency and exergy efficiency under all the conditions of evaporation temperature compared to TLC and BORC. As for the UA value, TLC has the largest one ranging from 7.9 kW/℃ to 8.8 kW/℃ under all conditions while OFC gains the minimum UA value at low evaporation temperature and BORC gains the minimum UA value at high evaporation temperature.
Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization (2014)

While tumor blood vessels share many characteristics with normal vasculature, they also exhibit morphological and functional aberrancies. For example, the neural adhesion molecule L1, which mediates neurite outgrowth, fasciculation, and pathfinding, is expressed on tumor vasculature. Here, using an orthotopic mouse model of pancreatic carcinoma, we evaluated L1 functionality in cancer vessels. Tumor-bearing mice specifically lacking L1 in endothelial cells or treated with anti-L1 antibodies exhibited decreased angiogenesis and improved vascular stabilization, leading to reduced tumor growth and metastasis. In line with these dramatic effects of L1 on tumor vasculature, the ectopic expression of L1 in cultured endothelial cells (ECs) promoted phenotypical and functional alterations, including proliferation, migration, tubulogenesis, enhanced vascular permeability, and endothelial-to-mesenchymal transition. L1 induced global changes in the EC transcriptome, altering several regulatory networks that underlie endothelial pathophysiology, including JAK/STAT-mediated pathways. In particular, L1 induced IL-6-mediated STAT3 phosphorylation, and inhibition of the IL-6/JAK/STAT signaling axis prevented L1-induced EC proliferation and migration. Evaluation of patient samples revealed that, compared with that in noncancerous tissue, L1 expression is specifically enhanced in blood vessels of human pancreatic carcinomas and in vessels of other tumor types. Together, these data indicate that endothelial L1 orchestrates multiple cancer vessel functions and represents a potential target for tumor vascular-specific therapies.
Latent infection in vivo by the varicella-zoster virus (VZV) in the rat nervous system (1989)

peer reviewed
The Synthesis of Tyrosine Mimetics via a Novel N(1)‐C(4) β‐Lactam Cleavage Reaction (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
<I>Rickettsiella</I>-like Bacteria in <I>Ixodes woodi</I> (Acari: Ixodidae) (2002)

We examined a parthenogenetic strain of the hard tick Ixodes woodi Bishopp for the presence of endosymbiotic bacteria. Electron microscopic examination revealed the ovarian tissues and Malpighian tubules were infected with pleomorphic bacteria. Two basic types were observed: a larger granular cell and a smaller condensed cell. Cloning and sequence analysis of polymerase chain reaction (PCR) amplified 16S rRNA gene yielded a single sequence from bacteria present in I. woodi tissues. Phylogenetic analysis of the nearly complete 16S rDNA indicated that the ticks were infected with an endosymbiont belonging to the gamma subdivision of the Proteobacteria. It clustered with the insect pathogenic species Rickettsiellagrylli (Vago and Martoja 1963) and the animal pathogen Coxiella burnetii (Derrick 1939) Philip 1948. Our results suggest that the I. woodi females harbored a single endosymbiotic bacterium related to selected Rickettsiella species and to C burnetii.
Biorenewable copolyesters derived from a biobased carbohydrate and lignin (2012)

absent
Relevance of Trehalose in Pathogenicity: Some General Rules, Yet Many Exceptions (2013)

Trehalose: A Supporting Act More than a Starring Role
Elucidation of the Chemistry of Enzyme-Bound Thiamin Diphosphate Prior to Substrate Binding:  Defining Internal Equilibria among Tautomeric and Ionization States (2007)

Both solution and crystallographic studies suggest that the 4'-aminopyrimidine ring of the thiamin diphosphate coenzyme participates in catalysis, likely as an intramolecular general acid-base catalyst via the unusual 1',4'-iminopyrimidine tautomer. It is indeed uncommon for a coenzyme to be identified in its rare tautomeric form on its reaction pathways, yet this has been possible with thiamin diphosphate, in some cases even in the absence of substrate [Nemeria, N., Chakraborty, S., Baykal, A., Korotchkina, L., Patel, M. S., and Jordan, F. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 78-82.]. The ability to detect both the aminopyrimidine and iminopyrimidine tautomeric forms of thiamin diphosphate on enzymes has enabled us to assign the predominant tautomeric form present in individual intermediates on the pathway. Herein, we report the pH dependence of these tautomeric forms providing the first data for the internal thermodynamic equilibria on thiamin diphosphate enzymes for the various ionization and tautomeric forms of this coenzyme on four enzymes: benzaldehyde lyase, benzoylformate decarboxylase, pyruvate oxidase, and the E1 component of the human pyruvate dehydrogenase multienzyme complex. Evidence is provided for an important function of the enzyme environment in altering both the ionization and tautomeric equilibria on the coenzyme even prior to addition of substrate. The pKa for the 4'-aminopyrimidinium moiety coincides with the pH for optimum activity thereby ensuring that all ionization states and tautomeric states are accessible during the catalytic cycle. The dramatic influence of the protein on the internal equilibria also points to conditions under which the long-elusive ylide intermediate could be stabilized.
Transcriptional Regulation of the Base Excision Repair Pathway by BRCA1 (2010)

Inactivation of the breast cancer susceptibility gene BRCA1 plays a significant role in the development of a subset of breast cancers, although the major tumor suppressor function of this gene remains unclear. Previously, we showed that BRCA1 induces antioxidant-response gene expression and protects cells against oxidative stress. We now report that BRCA1 stimulates the base excision repair pathway, a major mechanism for the repair of oxidized DNA, by stimulating the activity of key base excision repair (BER) enzymes, including 8-oxoguanine DNA glycosylase (OGG1), the DNA glycosylase NTH1, and the apurinic endonuclease redox factor 1/apurinic endonuclease 1 (REF1/APE1), in human breast carcinoma cells. The increase in BER enzyme activity appears to be due, primarily, to an increase in enzyme expression. The ability of BRCA1 to stimulate the expression of the three BER enzymes and to enhance NTH1 promoter activity was dependent upon the octamer-binding transcription factor OCT1. Finally, we found that OGG1, NTH1, and REF1/APE1 each contribute to the BRCA1 protection against oxidative stress due to hydrogen peroxide and that hydrogen peroxide stimulates the expression of BRCA1 and the three BER enzymes. These findings identify a novel mechanism through which BRCA1 may regulate the repair of oxidative DNA damage.
Influence of pump wavelength and crystal length on the phase matching of optical rectification (2005)

We present measurements on terahertz generation by optical rectification, in which both the thickness of the generation crystal and the wavelength of the generating optical pulse are varied. The difference between the group velocity at optical frequencies and the phase velocity at terahertz frequencies affects the time trace and spectrum of the generated terahertz pulse. For the thickest crystal, we find that the phase mismatch gives rise to the generation of two pulses, separated by 4.5 ps. The physical origin of the observed features is clarified with a simple model that includes phase matching and absorption.
Four gene products are required for the fungal synthesis of the indole‐diterpene, paspaline (2006)

Paspaline belongs to a large, structurally and functionally diverse group of indole-diterpenes synthesized by filamentous fungi. However, the identity of the gene products required for the biosynthesis of paspaline, a key intermediate for the synthesis of paxilline and other indole-diterpenes, is not known. Transfer of constructs containing different pax gene combinations into a paxilline negative deletion derivative of Penicillium paxilli demonstrated that just four proteins, PaxG, a geranylgeranyl diphosphate synthase, PaxM, a FAD-dependent monooxygenase, PaxB, a putative membrane protein, and PaxC, a prenyl transferase, are required for the biosynthesis of paspaline.
Design of a capacitive ECG sensor for unobtrusive heart rate measurements (2013)

The increased prevalence of cardiovascular disease among the aging population has prompted greater interest in the field of smart home monitoring and unobtrusive cardiac measurements. This paper introduces the design of a capacitive electrocardiogram (ECG) sensor that measures heart rate with no conscious effort from the user. The sensor consists of two active electrodes and an analog processing circuit that is low cost and customizable to the surfaces of common household objects. Prototype testing was performed in a home laboratory by embedding the sensor into a couch, walker, office and dining chairs. The sensor produced highly accurate heart rate measurements (<; 2.3% error) via either direct skin contact or through one and two layers of clothing. The sensor requires no gel dielectric and no grounding electrode, making it particularly suited to the “zero-effort” nature of an autonomous smart home environment. Motion artifacts caused by deviations in body contact with the electrodes were identified as the largest source of unreliability in continuous ECG measurements and will be a primary focus in the next phase of this project.
Perianal Paget's disease (1990)

A case of locally extensive perianal Paget's disease is presented. Initial wide local excision, guided by frozen sections, was inadequate. Multiple punch biopsies subsequently revealed extensive circumferential involvement of the anoderm by Paget's disease, making wide local excision difficult. Therefore, the patient was treated with combined chemoradiotherapy (5000 cGy, 5-fluorouracil, and mitomycin C). Fourteen months after treatment, the patient had a complete response.
RF-energy harvesting and wireless power transfer efficiency from digitally modulated signals (2015)

The RF-DC conversion efficiency of an RF harvesting circuit when it is excited by digitally modulated signals is investigated. A variety of signals with the same average power but different complementary cumulative distribution function (CCDF) and peak-to-average-power ratio (PAPR) properties are applied at the input of a prototype UHF diode rectifier. The rectifier is optimized for maximum efficiency under low average input power levels and the RF-DC conversion efficiency for different output load conditions is evaluated. It is shown that depending on the CCDF and PAPR properties of the applied signal a different optimum load exists which leads to a maximum efficiency.