gebhart/patrepeval huggingface dataset:
Quality-of-life benefits and evidence of antitumour activity for patients with brain metastases treated with gefitinib (2003)

Brain metastases are a common complication of non-small-cell lung cancer (NSCLC). The role of chemotherapy in the treatment of brain metastases has not been clearly defined. Emerging case reports of patients with recurrent NSCLC treated as part of the Expanded Access Programme reveal that gefitinib ("Iressa", ZD1839) has clinical activity in some patients with brain metastases. Here, we describe a number of case studies documenting the response of patients with brain metastases to treatment with gefitinib. Many of these patients had quality-of-life benefits with improvement of neurological and systemic symptoms; some had a partial response of their brain metastases and even complete responses have been seen in a few patients. One case report also describes a durable long-term response with concurrent treatment with gefitinib and radiotherapy. Such results call for larger trials designed to evaluate and define the role of gefitinib in the treatment of brain metastases in NSCLC patients, either as a single agent or in combination with radiation therapy.
[The importance of syndrome X in daily practice]. (2000)

Metabolic syndrome X includes glucose intolerance or type 2 diabetes, dyslipidemia and arterial hypertension which are classical cardiovascular (CV) risk factors. In course of time, other CV risk factors have been added to the syndrome: rheological alterations, endothelial dysfunction, anomalies in the coagulation/fibrinolysis system, microalbuminuria and so on.... Insulin resistance is the cornerstone of metabolic syndrome X, with secondary hyperinsulinism. Upper body obesity is associated with metabolic syndrome X. Simple waist measurements can detect the subjects (10-15% of the population) at increased CV risk with a sensitivity of 70%. This is invaluable for such a simple and cheap test. Diet is the first step in treating these patients and reducing caloric intake is necessary in most of them. Saturated fats will be replaced by polyunsaturated and mono-unsaturated ones. Long-chain carbohydrates with low glycemic index will be suggested. Regular physical activity will be promoted. If these life style modifications fail, drugs can be added: biguanide and glitazone are good candidates. Orlistat has improved metabolic syndrome X on a long-term basis. Drugs that could increase insulin resistance are to be avoided.
IEC 61850 Based ElectricalProtection and Control Systemfor Nuclear Power Plants (2019)

Using IEC61850 across the Low Voltage (LV) and MediumVoltage (MV) protection systems allow the implementation of anumber of advanced features such as logic selectivity interlockingwhen a short circuit occurs. In addition to improved logic selectivityand higher overall reliability, use of a single protocol offers acommon interface for plant supervision and monitoring, providingmore and better-quality data to operators so they can run the plantin an optimum way. This paper proposes the IEC61850technology based electrical protection and control system for theMV and LV networks in nuclear power plants. Current practicesare reviewed and then introduce the methodologies of how toapply IEC61850 in the electrical protection and control systems ofnuclear power plants. Finally, the expected advantages andchallenges will be elaborated.
Anion recognition and sensing of ruthenium(ii) and cobalt(ii) sulfonamido complexes (2009)

A series of artificial receptors, based on a sulfonamido system, have been designed and synthesized. The interaction of these receptors with biologically important anions was determined by UV-vis, (1)H NMR titration and electrochemical experiments. Results indicate that these receptors show high recognition abilities for fluoride (F(-)) or acetate (AcO(-)), moderate affinities for dihydrogen phosphate (H(2)PO(4)(-)) or hydroxyl (OH(-)) and almost no affinities for chloride (Cl(-)), bromide (Br(-)) or iodide (I(-)). (1)H NMR titration shows that the interaction between the receptors and anions depends on the hydrogen-bond formation. The Co(III)/Co(II) redox signals of receptor and disappear gradually when the fluoride or acetate anions are added. Moreover, visual color changes accompany guest binding, enabling this system to act as colorimetric anion sensors. The colorimetric properties of these sensors are ascribed to the hydrogen-bond formation and the colorimetric group quinoxaline.
Artificial Matrix Helps Neonatal Cardiomyocytes Restore Injured Myocardium in Rats (2006)

The purpose of this study was to investigate whether an artificial matrix can help neonatal cardiomyocytes restore an injured heart in a rat model of myocardial infarction (MI). The left coronary arteries of female Sprague Dawley (SD) rats were ligated to create MI models. Ventricular cardiomyocytes from 1- to 3-day-old SD rats (both sexes) were isolated, cultured, and labeled. Three weeks after MI, the animals were randomized into four groups: (i) group cell plus matrix (n = 12); (ii) group cell (n = 12); (iii) group matrix (n = 12); and (iv) group control (n = 11). Four weeks after transplantation, echocardiography and the Langerdoff model were used to assess heart function. Immunohistochemical staining and polymerase chain reaction (PCR) were performed to track the implanted cardiomyocytes and detect the sex-determining region Y gene on the Y chromosome. Histology study and PCR showed that transplanted cardiomyocytes survived, formed condensed tissue, and produced connected protein in group cell plus matrix. Heart function assessment indicated transplantation of cardiomyocytes plus matrix preserved left ventricle wall thickness, fraction shortening, and end-systolic internal diameter most effectively.
Mejora de las competencias tecnológicas del docente en la educación media superior (2010)

Este trabajo tiene como objetivo investigar el nivel de desempeno en Competencias Genericas y Especificas de los Profesores de la Escuela Preparatoria Fernando Enrique Angli Lara, en el uso de los programas de Word, Excel y PowerPoint
Este estudio fue exploratorio de tipo descriptivo y utilizo metodos mixtos de recoleccion de datos. La investigacion se realizo en la ciudad de San Francisco de Campeche, Campeche, Mexico; a un total de 23 docentes e involucro: analisis documental, visitas de campo, cuestionarios, entrevistas cualitativas y observaciones.
Se encontro que las competencias especificas que presentaron un desempeno medio alto son: Word y Power Point. En la competencia especifica de Excel manifestaron un desempeno medio. Aunque no todos los profesores utilizan estas tecnologias en sus clases, sus actitudes se han venido flexibilizando con el fin de hacer frente a los tiempos actuales y en beneficio de la mejora de los procesos de ensenanza-aprendizaje. La mayoria de las competencias que los docentes tienen en estas tecnologias son el producto de una voluntaria autoformacion. Es recomendable que la institucion promueva la capacitacion de este tipo de cursos, aunado al apoyo tecnico y formativo que los docentes requieren en beneficio de la mejora de la calidad educativa.
Indexing high-dimensional data for content-based retrieval in large databases (2003)

Many indexing approaches for high-dimensional data points have evolved into very complex and hard to code algorithms. Sometimes this complexity is not matched by increase in performance. Motivated by these ideas, we take a step back and look at simpler approaches to indexing multimedia data. In this paper we propose a simple, (not simplistic) yet efficient indexing structure for high-dimensional data Points of variable dimension, using dimension reduction. Our approach maps multidimensional points to a 1D line by computing their Euclidean Norm and use a B/sup +/-Tree to store data points. We exploit B/sup +/-Tree efficient sequential search to develop simple, yet performant methods to implement point, range and nearest-neighbor queries. To evaluate our technique we conducted a set of experiments, using both synthetic and real data. We analyze creation, insertion and query times as a function of data set size and dimension. Results so far show that our simple scheme outperforms current approaches, such as the Pyramid Technique, the A-Tree and the SR-Tree, for many data distributions. Moreover, our approach seems to scale better both with growing dimensionality and data set size, while exhibiting low insertion and search times.
Aspects of the Gemini real-time operating system (1967)

Three generations of programming systems have provided realtime ground support for manned spaceflight programs. The first of these was the Mercury system, which became operational in 1960. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> The third and current system supports the Apollo program. The subject of this paper is the second in the series, the Gemini system, developed for NASA at the Manned Spaceflight Center in Houston, Texas.
Energy storage system scheduling in wind-diesel microgrids (2010)

This thesis proposes a knowledge based expert system tool that can be used as an online controller for the charging/discharging of an energy storage system in a wind-diesel microgrid.The wind-diesel microgrid is modelled, and a typical energy storage system is implemented to test the functionality of the controller using hourly-discrete power values.The results are compared against an offline optimization that was provided 24-hour lookahead wind values, as well as a controller that was implemented using artificial neural networks.The knowledge based expert system is then used to analyze the cost of energy, by means of a parametric analysis, consisting of varying the wind penetration, energy storage system power rating and energy rating to determine for which wind penetration values a storage system implementation would be technically and economically viable.Different storage technologies are tested in a one-year time frame to determine which would be best suited for this particular application.The energy storage systems are implemented as single-layer and dual-layer, in which the knowledge based expert system is modified for the latter analysis, in order to determine whether or not there are advantages to having a dual-layer storage system.Throughout these analyses, the flexibility of the knowledge based expert system controller to various energy storage systems and microgrid models is verified.It also demonstrates that, in a context of high base generation costs, energy storage can be a viable solution to managing wind power variations.I would like to sincerely thank my supervisor, Professor Gza Jos, for his guidance and support throughout my Master's studies.I have learned so much in my education at McGill University, and I owe a large part of that to Professor Jos.He challenged me with high objectives and pushed me to always strive to be better, and he was always able to reward the hard work.I am extremely
Techniques for Using Liquid Helium in Very Low Temperature Apparatus (1966)

A discussion of what is known experimentally about the thermal contact problem at very low temperatures is given. Liquid 4He is a particularly promising contact agent. Methods of using liquid 4He, thermometry using cerium magnesium nitrate, and solutions to the filling and isolation problems using an open capillary are discussed. The techniques are applied to an apparatus suitable for heat capacity measurements to below 0.02°K and to an apparatus for measurement of superconductive properties at temperatures substantially below 0.01°K. The performance of the apparatus for heat capacity and superconductivity measurements is discussed.
MECHANISM OF ACTION OF MUSCARINE ON THE LONGITUDINAL MUSCLE OF THE GUINEA‐PIG ISOLATED ILEUM (1981)

1 DL-Muscarine elicited a contraction of the ileal longitudinal muscle of the guinea-pig and the contraction was characterized by an after-response. 2 Physostigmine (20 x 10(8) M) potentiated the contraction of the longitudinal muscle elicited by DL-muscarine. 3 Hemicholinium-3 (HC-3) caused a rightward shift of the dose-response curve to DL-muscarine on the ileal longitudinal muscle of the guinea-pig ileum. 4 beta-Bungarotoxin (10 microgram/ml) significantly (P < 0.025) reduced the contraction elicited by DL-muscarine (2.5 X 10(-8) M) suggesting presynaptic release of acetylcholine as an indirect mechanism of action of DL-muscarine. 5 Morphine (1.0 x 10(-8) M) significantly (P < 0.05) reduced the contractions elicited by DL-muscarine (2.5 x 10(-8) M) further suggesting presynaptic release of acetylcholine as an indirect mechanism of action of DL-muscarine. 6 A subthreshold dose of DL-muscarine (2.0 x 10(-10) M) potentiated the effect of acetylcholine (2.5 x 10(-8) M) and the potentiation was blocked by beta-bungarotoxin.
Serious Infections Caused by Methicillin‐Resistant<i>Staphylococcus aureus</i> (2010)

Although first identified just >4 decades ago, methicillin-resistant Staphylococcus aureus (MRSA) has undergone rapid evolutionary changes and epidemiologic expansion to become a major cause of nosocomial and community-acquired infections worldwide. Increasing resistance to vancomycin among MRSA strains in conjunction with availability of new antibiotics, including daptomycin and linezolid, have increased treatment choices but made clinical treatment decisions more challenging. This article describes the clinical features and management issues of 2 challenging-to-treat manifestations of MRSA infection, bacteremia and/or endocarditis and osteomyelitis. It also presents a brief review of community-associated MRSA infections and preventive strategies directed against MRSA.
Housekeeping Gene Selection Advisory: Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and β-Actin Are Targets of miR-644a (2012)

Results of overexpression or downregulation of a microRNA (miRNA) on its target mRNA expression are often validated by reverse-transcription and quantitative PCR analysis using an appropriate housekeeping gene as an internal control. The possible direct or indirect effects of a miRNA on the expression of housekeeping genes are often overlooked. Among many housekeeping genes, expressions of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin have been used extensively for normalization of gene expression data. Here, we show that GAPDH and β-actin are direct targets of miR-644a. Our data demonstrate the unsuitability of GAPDH and β-actin as internal controls in miR-644a functional studies and emphasize the need to carefully consider the choice of a reference gene in miRNA experiments.
The Monasteries of Mount Athos (1928)

The peninsula of Athos, home of monks, resort of pilgrims and the sole surviving example of the life of the Middle Ages which exists in Europe, is the only spot in these days of hooting motor cars, roaring machinery and rushing, busy people, in which it is possible to lead a completely altered life. There only in Europe can one meet an entirely original mental outlook. Even in the remotest European village everyday life is of this age and it is only by exercising the imagination that one can transfer oneself to the past. But on arrival on Athos this earth is left behind and one begins to experience the life of a pilgrim of the Middle Ages. One sees from actual experience what that life really was, and one continues to live it until the discomforts of the thirteenth century finally persuade one that the evils of this age are amply repaid by its merits and that the romance of the Middle Ages is even excelled by the adventurous spirit of today. The medieval life is something that one likes to remember as a curiosity, something to be experienced occasionally only. But the claims of its art are more lasting and in these days of ease and luxury we can appreciate them the more fully.
Aseptic Meningitis in Children: Analysis of 506 Cases (2007)

Enteroviruses accounted for approximately one half of cases of aseptic meningitis. PCR may reduce the length of hospitalization and plays important role in the diagnosis and management of children with aseptic meningitis.
Time delay estimation via cross-correlation in the presence of large estimation errors (1982)

The estimate of the difference in time of arrival of a common random signal received at two sensors, each of which also receives uncorrelated noise, is examined for both small and large estimation errors. It is shown that as the post-integration signal-to-noise ratio decreases, the correlator exhibits a thresholding effect; that is, the probability of a large error (an anomalous estimate) increases rapidly. Approximate theoretical results for the probability of an anomaly are presented and are verified experimentally. The variance of the time delay estimate is examined for both a gated mode, in which the time delay corresponding to the correlation peak closest to the true time delay is used as the estimate of time delay, and an ungated mode, in which the time delay corresponding to the largest peak over the full range of the correlator delay times is used as the estimate. The observed variance for both modes is compared with the theoretical variance based on a small error analysis. For the gated modes, the signal-to-noise ratio below which the observed variance begins to differ significantly from the small error theory can be reliably predicted from a linearity criterion. It is shown, however, that the expected variance for the ungated mode can depart from the small error theory at a higher signal-to-noise ratio than for the gated modes; thus the variance due to anomalies can be the most important factor in determining the region of applicability of the small error analysis.
Gov Docs are Special Too! Primary Source Instruction using Government Information Collections (2019)

Introduction - 3 Presenters Case Studies and Lesson Plans Discussion Questions Selecting Sources Addressing Challenges Outcomes Recommended Resources Questions/Discussion
Does testosterone affect effect? (2004)

Fur was once the most important commodity propelling Canada's economic development. The fur trade peaked in the late 17th and early 18th centuries, when European fashion dictated an extravagent harvest of beaver fur. In more recent times, Canadians have questioned, re-evaluated and discarded the
Validation of the five-factor model of personality across instruments and observers. (1987)

Two data sources--self-reports and peer ratings--and two instruments--adjective factors and questionnaire scales--were used to assess the five-factor model of personality. As in a previous study of self-reports (McCrae & Costa, 1985b), adjective factors of neuroticism, extraversion, openness to experience, agreeableness-antagonism, and conscientiousness-undirectedness were identified in an analysis of 738 peer ratings of 275 adult subjects. Intraclass correlations among raters, ranging from .30 to .65, and correlations between mean peer ratings and self-reports, from .25 to .62, showed substantial cross-observer agreement on all five adjective factors. Similar results were seen in analyses of scales from the NEO Personality Inventory. Items from the adjective factors were used as guides in a discussion of the nature of the five factors. These data reinforce recent appeals for the adoption of the five-factor model in personality research and assessment.
Redefining the Server as Home Networks Emerge (2008)

Forrester Research, issued a US market forecast for home servers with a more than 10-fold increase between 2007 and 2012, from 400,000 to 4.5 million units. However, Gownder says that the industry will have to state the case for more efficient storage and retrieval of home networks to the vast bulk of potential customers, even those who run home-based data-dependent businesses.
The nature of magnetic interactions in CoFe-Ag(Cu) granular thin films (2000)

The effect of dipolar and exchange interactions on the magnetic behaviour of sputtered CoFe-Ag(Cu) granular alloys is examined through the study of remanence curves and Mplots as a function of the ferromagnetic volume content, xv , and annealing temperature. As-deposited samples, with either a random distribution of weakly interacting fine magnetic particles (3 nm in size) at low xv or with strong dipolar and exchange interactions (leading to a long range out-of-plane stripe-like domain structure) at xv 0.25, display negative Mvalues. In the former, this is attributed to dipolar interactions being dominant in a random distribution of well separated particles. In the latter, M <0 is attributed to the flux closure between antiparallel neighbouring domains, which is strongly demagnetizing. Annealing causes phase segregation and particle growth, while particle clusterization occurs. These facts lead to an increase of the direct exchange through the surface of neighbouring grains in the same particle clusters, at the expense of dipolar interactions, which decrease as the clusters become more separated. Consequently, at high xv , annealed samples display positive Mvalues.
Mercury Toxicity and Treatment: A Review of the Literature (2011)

Mercury is a toxic heavy metal which is widely dispersed in nature. Most human exposure results from fish consumption or dental amalgam. Mercury occurs in several chemical forms, with complex pharmacokinetics. Mercury is capable of inducing a wide range of clinical presentations. Diagnosis of mercury toxicity can be challenging but can be obtained with reasonable reliability. Effective therapies for clinical toxicity have been described.
Cooperação cinematográfica atual entre Brasil e Argentina (2006)

A producao cinematografica no Brasil e na Argentina experimentou um significativo desenvolvimento, depois de algum tempo em que esteve bloqueada por crises politicas e economicas ou por politicas culturais adversas. No Brasil o fenomeno passou a ser denominado de da retomada. Mas recentemente algumas iniciativas dos governos da Brasil e da Argentina introduziram, no âmbito do Mercosul Cultural, uma nova dinâmica nao so na producao, mas principalmente na distribuicao e exibicao desta producao, permitindo a circulacao destes filmes no espaco dos dois paises. A Reuniao Especializada de Autoridades Cinematograficas e Audiovisuais do Mercosul e Paises Associados (RECAM) realizada em 2003 na cidade de Mar Del Plata e fundamental como marco desta mudanca, bem como a atuacao da Agencia Nacional de Cinema da Republica Federativa do Brasil (ANCINE) e do Instituto Nacional de Cine y Artes Audiovisuales da Republica Argentina. No âmbito da RECAM e do Mercosul Cultural foi estabelecido o Acordo de Distribuicao Brasil-Argentina. Este texto analisa este conjunto atual de iniciativas de politicas culturais voltadas para a cooperacao no campo do cinema entre Brasil e Argentina.
Motions of the Retinal Image during Fixation* (1954)

The ability of an observer to maintain steady fixation on a test object is limited by involuntary eye tremor. Such tremor is characteristic of balanced muscular systems such as those serving to rotate the eye. Rotations of the eye cause proportional displacements of the retinal image of a stationary test object. Data are given for typical excursions of the retinal image during various exposure intervals from 0.01 to 1 sec in duration. The data show that under good experimental conditions the retinal image is virtually stationary for exposures up to 0.01 sec in duration. Exposures of 0.1 sec entail an average displacement of 25 sec of arc (a visual angle corresponding to the diameter of a single foveal cone). Exposures as long as 1 sec permit an average excursion of about 3 min of arc.
Distal tibial fractures (2007)

Information from four case series on the treatment of distal tibial fractures by intramedullary (IM) nailing and five case series where plating was used indicates that fracture union rates are high after either treatment, but malunion may occur less often after IM nailing than after plating. Reoperation rates varied widely among studies. Hardware breakage and infection rates were low. Well-designed comparative studies are needed to more effectively compare these two treatment options.