gebhart/patrepeval huggingface dataset:
Involvement of the N-terminal B-box Domain of Arabidopsis BBX32 Protein in Interaction with Soybean BBX62 Protein (2012)

Previous studies have demonstrated that Arabidopsis thaliana BBX32 (AtBBX32) represses light signaling in A. thaliana and that expression of AtBBX32 in soybean increases grain yield in multiple locations and multiyear field trials. The BBX32 protein is a member of the B-box zinc finger family from A. thaliana and contains a single conserved Zn(2+)-binding B-box domain at the N terminus. Although the B-box domain is predicted to be involved in protein-protein interactions, the mechanism of interaction is poorly understood. Here, we provide in vitro and in vivo evidence demonstrating the physical and functional interactions of AtBBX32 with another B-box protein, soybean BBX62 (GmBBX62). Deletion analysis and characterization of the purified B-box domain indicate that the N-terminal B-box region of AtBBX32 interacts with GmBBX62. Computational modeling and site-directed mutagenesis of the AtBBX32 B-box region identified specific residues as critical for mediating the interaction between AtBBX32 and GmBBX62. This study defines the plant B-box as a protein interaction domain and offers novel insight into its role in mediating specific protein-protein interactions between different plant B-box proteins.
Catecholamines and contractility of the human myometrium at term: a possible role for prostaglandins. (1985)

The contractile response of small myometrial specimens from the term pregnant human uterus was investigated using a superfusion technique. Adrenaline, noradrenaline and dopamine all had a stimulatory effect on the contractility. It was also demonstrated that this stimulatory effect was alpha-adrenoceptor mediated. If the tissue was pretreated with the prostaglandin synthetase inhibitor indomethacin or the arachidonic acid analogue eicosa-5,8,11,14-tetraenoic acid the effect of catecholamines was significantly reduced. This suggests a specific role of prostaglandins in the mechanism of action of catecholamines on the human myometrium.
Table S2 from Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas (2023)

<p>CpGs and genes associated with differential methylation and expression with respect to high-risk (HR) neuroblastoma disease</p>
University of Waterloo at TREC 2011 Microblog Track. (2011)

For the first year of the Microblog Track, a real time ad hoc search task was determined to be a suitable first task. The goal of the track is to return the most recent but also relevant tweets for a user’s query. Participating
Synthesis of 2-Mercapto- and 2-Hydroxy-Substituted Diphenylphosphines for use as Dianionic Bidentate Ligands and Polydentate Ligand Precursors (1996)

Abstract As part of our studies into the synthesis of polydentate phosphine-containing ligands, we have investigated the preparation of the phosphines (4; X[dbnd]O) and (4; X[dbnd]S). These are of interest both as potential dianionic bidentate ligands and as useful precursors of more complex polydentate ligand systems. A synthesis of the thiol system (4; X[dbnd]S) from 1,2-dinitrobenzene has been previously reported [1], but the observation [2], that 2-bromoaryl esters of phosphoric acid rearrange to give esters of arylphosphonic acids in the presence of alkyl lithiums, led us to consider whether a similar type of rearrangement might provide a convenient approach to both (4; X[dbnd]S) and (4; X[dbnd]O).
Crystal Structures and Solution Behavior of Paramagnetic Divalent Transition Metal Complexes (Fe, Co) of the Sterically Encumbered Tridentate Macrocycles 1,4,7-R<sub>3</sub>-1,4,7-Triazacyclononane:  Coordination Numbers 5 (R = <i>i</i>-Pr) and 6 (R = <i>i</i>-Bu) (2000)

The coordination chemistry of the sterically hindered macrocyclic triamines, 1,4,7-R3-1,4,7-triazacyclononane (R = i-Pr, i-Pr3tacn, and R = i-Bu, i-Bu3tacn) with divalent transition metals has been investigated. These ligands form a series of stable novel complexes with the triflate salts MII(CF3SO3)2 (M = Fe, Co, or Zn) under anaerobic conditions. The complexes Fe(i-Pr3tacn)(CF3SO3)2 (2), [Co(i-Pr3tacn)(SO3CF3)(H2O)](CF3SO3) (3), [Co(i-Pr3tacn)(CH3CN)2](BPh4)2 (4), Zn(i-Pr3tacn)(CF3SO3)2 (5), [Fe(i-Bu3tacn)(CH3CN)2(CF3SO3)](CF3SO3) (6), Fe(i-Bu3tacn)-(H2O)(CF3SO3)2 (7), and Co(i-Bu3tacn)(CF3SO3)2 (8) have been isolated. The behavior of these paramagnetic complexes in solution is explored by their 1H NMR spectra. The solid-state structures of four complexes have been determined by X-ray single-crystal crystallography. Crystallographic parameters are as follows. 2: C17H33F6FeN3O6S2, monoclinic, P2(1)/n, a = 10.895(1) A, b = 14.669(1) A, c = 16.617(1) A, beta = 101.37(1) degrees, Z = 4. 3: C17H35CoF6N3O7S2, monoclinic, P2(1)/c, a = 8.669(2) A, b = 25.538(3) A, c = 12.4349(12) A, beta = 103.132(13) degrees, Z = 4. 6: C24H45F6FeN5O6S2, monoclinic, P2(1)/c, a = 12.953(6) A, b = 16.780(6) A, c = 15.790(5) A, beta = 96.32(2) degrees, Z = 4. 7: C20H41F6FeN3O7S2, monoclinic, C2/c, a = 22.990(2) A, b = 15.768(2) A, c = 17.564(2) A, beta = 107.65(1) degrees, Z = 8. The ligand i-Pr3tacn leads to complexes in which the metal ions are five-coordinate, while it's isobutyl homologue affords six-coordinate complexes. This difference in the stereochemistries around the metal center is attributed to steric interactions involving the bulky alkyl appendages of the macrocycles.
Role of autoinducer-2 on the adhesion ability of<i>Lactobacillus acidophilus</i> (2009)

The ability to produce AI-2 affects the ability of L. acidophilus to attach to intestinal epithelial cells.
Investigation of YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-δ</sub> Superconducting Ceramics Intergranular Bonds with the Method of Nonresonant Microwave Adsorption (1996)

By the use of the electron spin resonance (ESR) method, the relation of intra- and intergranular components in a nonresonance microwave adsorption signal was investigated for superconducting YBa 2 Cu 3 O 7-δ samples. It is shown that different kinds of external influences on superconducting ceramics (annealing in oxygen at 500 °C and paramagnetic molecule adsorption onto the ceramics) lead to the enhancement of intergranular bonds, while the granular properties are scarcely affected by these treatments.
Three Aspects of Skill Acquisition (2018)

A theory is presented about how instruction and experience combine to produce competence in a complex skill. The theory depends critically on three components of the ACT-R architecture. The first component interprets declarative representations of instruction so that they lead to action. The second component converts this knowledge into procedural form so that appropriate actions can be quickly executed. The third component, newly added to the architecture, learns the setting of control parameters for actions through a process similar to reinforcement learning.. These three components are intermingled throughout the course of skill acquisition, providing an instantiation of Fitts’ (1964) original characterization of skill acquisition as involving gradual shifts in the factor structure of skills. The overall theory is implemented in computational models that are capable of simulating human learning in different versions of the video game Space Fortress. Other than humans, these models are the only agents, natural or artificial, capable of learning to play Space Fortress.
Cycloisomerization of Olefinic Carboxylic Acids Catalyzed by Trifluoromethanesulfonic Acid (2005)

Abstract The trifluoromethanesulfonic acid‐catalyzed cyclization of various differently substituted unsaturated carboxylic acids affords selectively substituted lactones in good yields. The reactions use 0.5 to 5% molar ratio of catalyst and can be run without solvent.
Cobalt catalysts for the conversion of CO2 to light hydrocarbons at atmospheric pressure (2013)

A series of cobalt heterogeneous catalysts have been developed that are effective for the conversion of CO2 to hydrocarbons. The effect of the promoter and loadings have been investigated.
Oxidation of Aromatic Acids. IV. Decarboxylation of Salicylic Acids (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of Aromatic Acids. IV. Decarboxylation of Salicylic AcidsWarren W. KaedingCite this: J. Org. Chem. 1964, 29, 9, 2556–2559Publication Date (Print):September 1, 1964Publication History Published online1 May 2002Published inissue 1 September 1964https://pubs.acs.org/doi/10.1021/jo01032a016https://doi.org/10.1021/jo01032a016research-articleACS PublicationsRequest reuse permissionsArticle Views675Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antitussive effect of (+/-) pentazocine in diabetic mice is mediated by delta-sites, but not by mu- or kappa-opioid receptors. (1994)

The effects of streptozotocin-induced diabetes on the antitussive effect of (+/-) pentazocine were examined in mice. Intracerebroventricular (i.c.v.) administration of (+/-) pentazocine produced a dose-dependent antitussive effect in both diabetic and non-diabetic mice. There were no significant differences in the antitussive effect of (+/-) pentazocine in diabetic and non-diabetic mice. The antitussive effect of i.c.v. (+/-) pentazocine was partially, but significantly, reduced in non-diabetic mice following pretreatment with either beta-funaltrexamine, a selective mu-opioid antagonist, or rimcazole, a specific sigma-site antagonist. The antitussive effect of (+/-) pentazocine in diabetic mice was significantly antagonized by pretreatment with rimcazole. However, beta-funaltrexamine had no effect on the antitussive effect of (+/-) pentazocine in diabetic mice. Furthermore, nor-binaltorphimine, a selective kappa-opioid receptor antagonist, had no significant effect on the antitussive effect of (+/-) pentazocine in either non-diabetic or diabetic mice. These results suggest that although the antitussive effect of i.c.v. (+/-) pentazocine in non-diabetic mice is mediated by both mu-opioid receptors and sigma-sites, in diabetic mice this effect is mainly mediated by sigma-sites.
Measurement errors in multifrequency bioelectrical impedance analyzers with and without impedance electrode mismatch (2009)

The purpose of this study is to compare measurement errors in two commercially available multi-frequency bioimpedance analyzers, a Xitron 4000B and an ImpediMed SFB7, including electrode impedance mismatch. The comparison was made using resistive electrical models and in ten human volunteers. We used three different electrical models simulating three different body segments: the right-side, leg and thorax. In the electrical models, we tested the effect of the capacitive coupling of the patient to ground and the skin-electrode impedance mismatch. Results showed that both sets of equipment are optimized for right-side measurements and for moderate skin-electrode impedance mismatch. In right-side measurements with mismatch electrode, 4000B is more accurate than SFB7. When an electrode impedance mismatch was simulated, errors increased in both bioimpedance analyzers and the effect of the mismatch in the voltage detection leads was greater than that in current injection leads. For segments with lower impedance as the leg and thorax, SFB7 is more accurate than 4000B and also shows less dependence on electrode mismatch. In both devices, impedance measurements were not significantly affected (p > 0.05) by the capacitive coupling to ground.
Abstract 152: MicroRNAs in head and neck squamous cell carcinoma (2011)

Abstract Background: The accumulating evidence indicates that microRNAs play a key role in tumor development and progression. The aim of this study is to assess the role and function of microRNAs in head and neck squamous cell carcinoma. Method and Results: We investigated expression profiles of microRNA in head and neck squamous cell carcinoma by using a miRNA microarray platform. Profiles from tumor samples (n=10) and nontumor tissues (n=10) were compared. We identified 24 differentially expressed miRNAs, of which 1 was significantly downregulated, while the other 23 were upregulated in tumor tissues. Mir-21 was most notably upregulated in tumor tissues (P=0.0002), and mir-375 was a potential tumor suppressive microRNA that was significantly downregulated in tumors (P=0.0002). Expression profiles of these two microRNAs were validated by qRT-PCR with separate clinical samples (16 tumors and 15 normal tissues). In vitro assays confirmed that mir-21 stimulated cell growth and mir-375 had a tumor suppressive role. Next, to assess downstream target genes, cells were subjected to microarray analysis after transient transfection with each microRNA or its negative control. We also conducted a bioinformatics search (TargetScan, PicTar, miRanda). By combining these data, we identified potential target genes including YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) for mir-375 and BNC2 (Basonuclin 2) for mir-21. These potential target genes were downregulated after forced expression of mir-375 or mir-21. The activities of a luciferase reporter containing these microRNA's binding sequences at the 3’ untranslated region (UTR) of some potential target mRNAs were repressed by the ectopic expression of miR-375 or miR-21, suggesting that some of these candidates are specific targets of these microRNAs. Conclusions: Mir-21 is a potential oncogenic microRNA, and miR-375 is a potential tumor-suppressive microRNA in head and neck squamous carcinoma. Further investigation including pathway analysis of these microRNAs may lead to the detection of therapeutic targets of head and neck cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 152. doi:10.1158/1538-7445.AM2011-152
Surface properties of c-plane GaN grown by plasma-assisted molecular beam epitaxy (2013)

Two series of GaN van Hoof structures with different thicknesses of an undoped GaN cap layer were grown under metal-rich conditions by plasma-assisted molecular beam epitaxy. These were then investigated by contactless electroreflectance (CER) to study the Fermi-level position of the (0001) GaN surface after growth as well as after chemical treatment using Piranha solution. The first and second series of samples were grown on GaN/sapphire templates and high-pressure bulk GaN crystals, respectively. A clear CER resonance followed by Franz–Keldysh oscillations (FKOs) of various periods was clearly observed for both sample series before and after chemical treatment. The Fermi-level position of the GaN surface was determined from the analysis of FKOs related to the built-in electric field in the undoped GaN layer. For the as-grown GaN surface, the Fermi level was found to be located 0.42 and 0.57 eV below the conduction band in samples grown on GaN/sapphire templates and high-pressure bulk GaN crystals, respectively. For the Piranha-etched GaN surfaces, the Fermi level was pinned at almost the same energy (0.49 and 0.48 eV) in each of the two sets of samples. This means that this cleaning procedure, which is commonly used before device processing, is able to saturate the surface states at a certain level of Fermi-level pinning.
Clinical background and its relation to results of percutaneous needle biopsy of suspected bone metastasis under guidance with CT fluoroscopy. (2005)

In the era of CT fluoroscopy, needle biopsy for suspected bone metastasis was most frequently requested for the patients who consulted orthopedic surgeons for the occurrence of local bone pain as the initial symptom of unknown malignancy. Frequency of malignancy proved by the biopsy in those patients was as high as that in the cancer patients referred from other clinicians.
The geographic apportionment of mitochondrial genetic diversity in east African chimpanzees, Pan troglodytes schweinfurthii (1997)

This study is a geographically systematic genetic survey of the easternmost subspecies of chimpanzee, Pan troglodytes schweinfurthii. DNA was noninvasively collected in the form of shed hair from chimpanzees of known origin in Uganda, Rwanda, Tanzania, and Zaïre. Two hundred sixty-two DNA sequences from hypervariable region 1 of which of the mitochondrial control region were generated. Eastern chimpanzees display levels of mitochondrial genetic variation which are low and which are similar to levels observed in humans (Homo sapiens). Also like humans, between 80% and 90% of the genetic variability within the eastern chimpanzees is apportioned within populations. Spatial autocorrelation analysis shows that genetic similarity between eastern chimpanzees decreases clinically with distance, in a pattern remarkably similar to one seen for humans separated by equivalent geographic distances. Eastern chimpanzee mismatch distributions (frequency distributions of pairwise genetic differences between individuals) are similar in shape to those for humans, implying similar population histories of recent demographic expansion. The overall pattern of genetic variability in eastern chimpanzees is consistent with the hypothesis that the subject has responded demographically to paleoclimatically driven changes in the distribution of eastern African forests during the recent Pleistocene.
Retrospective comparison of the George Gauge™ registration and the sibilant phoneme registration for constructing OSA oral appliances (2019)

<b>Objective</b>: To compare outcomes for appliances manufactured utilizing the George Gauge™ Registration (GGR) and the Sibilant Phoneme Registration (SPR). It was hypothesized that there would be no difference in outcomes.<b>Methods</b>: This study is a retrospective analysis of two groups. Each group consisted of 20 oral appliances manufactured utilizing the GGR and 20 utilizing the SPR.<b>Results</b>: For the two-site data, no difference in outcomes was demonstrated (<i>p</i> = .24). The SPR method required fewer calibrations (<i>p</i> = 5.6 × 10<sup>-3</sup>) and less jaw movement (<i>p =</i> 3.33 × 10<sup>-4</sup>). Both bite methods resulted in similarly variable post-AHI scores (<i>p</i> = .52). For the eight-site data, no difference in outcomes was demonstrated (<i>p</i> = .76). The SPR required less movement of the jaw (<i>p =</i> 4.52 × 10<sup>-5</sup>); however, outcome variance was larger for the SPR (<i>p</i> = .036).<b>Conclusion</b>: The study null hypothesis of no difference in outcomes was supported.<b>Abbreviations:</b> AHI: Apnea-Hypopnea Index; GGR: George Gauge Registration; SPR: Sibilant Phoneme Registration; OSA: Obstructive Sleep Apnea; OA: Oral Appliance; OAT: Oral Appliance Therapy; MA: Mandibular Advancement; VDO: Vertical Dimensional Opening; AADSM: American Academy of Dental Sleep Medicine; ABDSM: American Board of Dental Sleep Medicine; BMI: Body Mass Index.
Coaxial nozzle for control of particle morphology in precipitation with a compressed fluid antisolvent (1997)

A coaxial nozzle was developed to achieve further control over the morphology of microparticles precipitated from solution by carbon dioxide as a compressed fluid antisolvent. The polymer solution was sprayed through the core of the nozzle and CO2 through the annulus. For the coaxial nozzle versus a standard nozzle, polystyrene and poly(L-lactic acid) particles can be larger by a factor of 3–8 with less flocculation. A reduction in the Weber number reduces atomization and larger droplets are formed in the jet, delaying precipitation. However, because of the much higher Reynolds number for the high velocity CO2, the mass transfer in the suspension outside of the jet is faster leading to less flocculation and agglomeration. For polyacrylonitrile, the delayed precipitation produces a transition from highly oriented microfibrils to microparticles. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 64: 2105–2118, 1997
The Design and Development of a New Biopsy Device for Prostate Cancer Examination (2002)

Prostate cancer is a typical disease that affects many men aged 40 and above. A biopsy is an invasive procedure for prostate cancer examination that requires skill and experience. In this project, a new transrectal ultrasound biopsy system is designed and developed. This system is a tissue sampling system for prostate cancer biopsy operation, which would provide ultrasonic image conformation of the location of biopsy samples and be able to obtain 4∼6 samples without the need to remove the system from rectum and reinsert it. The system consists of an ultrasound imaging instrument, biopsy tool, and a tissue sample storage device. The system function objectives are summarized, and a conceptual design scheme is developed. Based on the analysis of the system functions, a 3-dimensional model of this device has been built up.
Advanced Epidural Simulator with 3D Flexible Spine and Haptic Interface (2012)

Frontiers Abstracts Advanced Epidural Simulator with 3D Flexible Spine and Haptic Interface Neil Vaughan, Neil Vaughan Search for other works by this author on: This Site PubMed Google Scholar Venketesh N. Dubey, Venketesh N. Dubey School of Design, Engineering and ComputingBournemouth University, UK Search for other works by this author on: This Site PubMed Google Scholar Michael Y. K. Wee, Michael Y. K. Wee Search for other works by this author on: This Site PubMed Google Scholar Richard Isaacs Richard Isaacs Poole Hospital NHS Foundation Trust, Poole, UK Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Venketesh N. Dubey School of Design, Engineering and ComputingBournemouth University, UK Richard Isaacs Poole Hospital NHS Foundation Trust, Poole, UK J. Med. Devices. Mar 2012, 6(1): 017524 (1 pages) https://doi.org/10.1115/1.4026702 Published Online: March 12, 2012 Article history Received: May 27, 2011 Revision Received: November 7, 2011