gebhart/patrepeval huggingface dataset:
Endometrial leptin and leptin receptor expression in women with severe/moderate endometriosis (2004)

The leptin system has been implicated in reproductive function, acting at endocrine and paracrine levels. Recently, deregulation of this gene family has been linked to endometrial changes caused by endometriosis. In the present study, we compare the expression of leptin receptor mRNA during the pre-receptive (LH+2) and receptive (LH+9) phases in the eutopic endometrium from patients with severe/moderate endometriosis (n = 30) versus fertile controls (n = 12). In each patient, two endometrial samples were obtained at LH+2 and LH+9 in their natural cycles. When real-time quantitative fluorescent PCR was performed, an up-regulation of OB-RL and all the isoforms investigated was observed at LH+9 versus LH+2 in patients with and without endometriosis. However, no difference was found in the expression pattern of the total leptin receptor OB-RT, or in its long OB-RL and soluble HuB219.3 forms when the eutopic endometria of patients with severe/moderate endometriosis and fertile controls were compared. By means of in situ hybridization, total leptin receptor mRNA was localized in the luminal epithelium and the glands of the endometrium. The immunohistochemical analysis of the long form of leptin receptor was also performed in order to confirm these findings at the protein level. Finally, we have also shown similar leptin mRNA expression in both the control group and patients with endometriosis. In conclusion, we have not identified differences in the endometrial expression and localization of leptin and the leptin receptor when comparing the eutopic endometrium of women with severe/moderate endometriosis and fertile controls.
Lang X-Ray Topographic Studies of Ruby Grown by Different Methods (1966)

Abstract Crystals of ruby (Al 2 O 3 :Cr) are being grown at the present time by several standard procedures, e.g. , Verneuil, Czochralski, flux, and hydrothermal. Previous work has indicated wide variations in quality and type of defects. The present study is primarily concerned with ruby grown from PbO-PbF 2 fluxes. All crystals were examined in transmission with Mo K α1 radiation and a Rigaku Denki Lang camera. Samples were either sectioned from larger crystals or obtained as plates with natural growth faces. Results on flux-grown ruby have shown a severely banded substructure due to strain introduced by either the flux or chromium segregation. Crystals with a visible chromium gradient have shown fewer bands in those regions which were depleted of chromium. Annealing studies have been performed on ruby and all banded structure was dispersed into areas of fine particles with a much higher dislocation content. Other features of the substructure are described. These include the observation of Pendellosung fringes in wedgeshaped sections. Areas of nearly 0.5 cm 2 were found to be dislocation free. The X-ray results confirm etching experiments but the former yield more information on internal details other than dislocations. Recent data on sapphire (α-Al 2 O 3 ) have confirmed several tentative conclusions. Flux grown crystals have some bands due to flux segregation. However, sapphire crystals show higher perfection when compared to ruby. These results have been confirmed by rocking curves obtained on a double crystal X-ray spectrometer used in the parallel position. Measurements on the (00.12) reflection from the natural growth faces were performed with Cu K α1 radiation. Widths at half the maximum intensity were always found to be larger for ruby than for sapphire. Comparisons were made with respect to a perfect silicon crystal in the same geometry. Some preliminary experiments have been performed on Czochralski ruby prepared by the Linde Company and on hydrothermally grown ruby prepared at Airtron, Examples of defects observed in each case are given. They are highly unique to the growth method. The Lang method is shown to reveal more detail than other X-ray data. A brief discussion of ruby quality as a function of growth method is presented.
The impact of RF nonliniearities in an optical link on the contrast of imaging radars (2009)

The contrast of imaging radars is shown to be severely limited by RF nonlinearities, introduced by opto-electronic devices like intensity modulators. Limitations on the allowable modulation index are studied for linearly-chirped pulses returned from clutter.
An investigation of bistatic calibration techniques (2005)

Several popular bistatic calibration techniques are investigated and comparisons made between the relative merits of the various techniques. The analysis addresses sensitivity to object alignment error, sensitivity to polarization impurity, and ease of implementation. Both theoretical concepts and practical considerations are discussed based on measurements accomplished at the European Microwave Signature Laboratory of the European Commission Joint Research Center, Ispra, Italy. This facility has the capability to produce far-field fully polarimetric precision bistatic measurements in a 30-cm-diameter quiet zone, suitable for comparing different calibration methods.
High MHC class I expression correlates with slow growth in UV‐induced skin carcinomas in hairless mice (1998)

An experiment was set up to investigate the relationship, if any, between cell surface MHC class I expression and the growth rate for skin tumors induced by two different UV radiation regimens in hairless mice. Two groups of 20 hairless mice were each irradiated with either a UVA radiation source (2 SED per session) or broad-spectrum UV radiation (UVB) (8.1 SED per session) 5 days a week during the entire experiment. In the UVA group, 17 out of 20 animals developed tumors, and 10 of these grew to a diameter of > or = 5 mm. In the UVB group, 19 out of 20 animals developed tumors, and 15 of these grew to a diameter of > or = 5 mm. The tumor induction time, i.e. the time from the start of UV treatment to tumor appearance, was found to be significantly longer (p<0.01) in the UVA than in the UVB group. This is in accordance with previous findings. Of the 25 tumors growing to a diameter of > or = 5 mm, 11 were established as cultured cell lines (4 UVA and 7 UVB tumors). These uncloned cell lines were analyzed for surface expression of major histocompatibility complex class I by FACS analysis. There was a clear correlation between high MHC class I expression and slow growth of the individual tumors (p<0.05). This suggests a role for the MHC class I governed, i.e. cytotoxic T-cell-mediated, reactions in deciding the fate of UV-induced skin cancers. No correlation was found between MHC class I expression and tumor induction time.
Guest Editorial IEEE Transactions on Computers and IEEE Transactions on Nanotechnology Joint Special Section on Defect and Fault Tolerance in VLSI and Nanotechnology Systems (2016)

The papers in this special section focus on the technology and applications supported by defect/fault tolerance in very large scale integration and nanotechnology systems. With increasing demand for ever smaller, portable, energy-efficient, and high-performance electronic systems, scaling of CMOS technology continues. As CMOS scaling approaches physical limits, continued innovation in materials, manufacturing processes, device structures, and design paradigms have been necessary. High-κ oxide and metal-gate stack were introduced to address oxide leakage; thin body undoped channels, and multiple-gate structures were introduced to mitigate subthreshold leakage; restricted design rules were introduced to improve layout efficiency; yet CMOS technology continues to be challenged in the areas of device aging and reliability. While CMOS is expected to be the dominant semiconductor technology for the foreseeable future—due to for reasons that are both technological and financial, alternatives to CMOS technology are attracting attention from the researchers.
Seizure Freedom with YKP3089 as Adjunctive Therapy for Refractory Partial-Onset Seizures in Double-Blind Placebo-Controlled Trials (P2.019) (2016)

Objective: Analyze seizure-free rates in studies of a new investigational AED, YKP3089. Background: Complete/near-complete seizure control may be needed for a new AED to achieve clinically meaningful improvements in quality of life in patients with refractory epilepsy. Despite development of ~20 new AEDs, the proportion of seizure-free patients in adjunctive treatment studies remains low. To help patients with refractory epilepsy, new AED development may need to use complete seizure control as an efficacy criterion. We report seizure-free rates in two double-blind placebo-controlled studies of patients with refractory partial-onset seizures in which YKP3089 was significantly more effective than Placebo in traditional primary endpoints (median [percnt] seizure reduction; ≥50[percnt] seizure reduction). Methods: Adults with ≥3 or 4 seizures/28 days during 8-wk baseline despite treatment with 1-3 AEDs were randomized to Placebo or YKP3089 (C013: 200 mg/day; C017: 100, 200, or 400 mg/day). 6-week titration phase followed by 6-week (C013) or 12-week (C017) maintenance phase. [percnt] patients seizure-free during the entire maintenance phase was determined. Results: In Study C013, 109 and 113 patients were randomized to Placebo and YKP3089, respectively, with 91[percnt] and 90[percnt] completing maintenance. Seizure-free rates were 9[percnt] with Placebo and 28[percnt] (<0.001) with YKP3089 200 mg. In Study C017, 108 patients were randomized to Placebo; 108, 110, and 111 were randomized to 100, 200, and 400 mg/day YKP3089, and 87[percnt], 88[percnt], 82[percnt], and 73[percnt], respectively, completed maintenance. YKP3089 100, 200, and 400 mg produced seizure-free rates of 3[percnt], 11[percnt] (p=0.004), and 20[percnt] (p<0.001), respectively, vs. 1[percnt] with Placebo. Most common AEs were dose related and included somnolence, dizziness, fatigue, diplopia, and gait disturbances. Conclusions: Treatment with YKP3089 was highly effective vs. Placebo in achieving seizure freedom. Further research must determine the durability of this outcome. Studies sponsored by SK Life Science, Inc.
Numerical Investigation of Nonlinear Aeroelastic Effects on Flexible High-Aspect-Ratio Wings (2005)

A nonlinear aeroelastic analysis is developed to analyze the aeroelastic characteristics of flexible high-aspect-ratio wings at transonic speeds. This is achieved by directly coupling a three-dimensional geometric nonlinear methodology, based on a 12 degree-of-freedom beam finite element, with an Euler/Navier-Stokes computational fluid dynamics analysis. Static aeroelastic results are presented for an unswept and swept high-aspect-ratio wing. Unswept wing results show a reversal in twist due to the nonlinear torsion-bending coupling effects. Specifically, the torsional moments due to drag become large enough to cause the wing twist rotations to washin the wing tips, whereas the linear results show a washout twist rotation. The nonlinear twist results are attributed to the large bending displacements coupled with the large drag experienced by this flexible high-aspect-ratio wing at the transonic flow conditions. Swept wing results show that nonlinear torsion-bending effects tend to reduce the amount of washout as compared to a linear structural aeroelastic analysis, making the wing more prone to tip stall.
Effect of Smoothing the Pressure Trace on the Interpretation of Experimental Data for Combustion in Diesel Engines (2004)

<div class="htmlview paragraph">The disturbances in the cylinder gas pressure trace caused by combustion in internal combustion engines have an impact on the shape of the rate of heat (energy) release (RHR). It is necessary to smooth the pressure trace before carrying out the RHR calculations and making any interpretations for the combustion process. Different smoothing methods are analyzed and their features compared. Furthermore, the selection of the smoothing starting point and its effect on the smoothing quality of pressure data are described. The Fast Fourier Transform (FFT) analysis is applied to determine the frequency of the disturbances in power spectrum and obtain the optimal specified smoothing parameter (SSP). The experimental data was obtained on a single-cylinder research diesel engine, running under simulated turbocharged steady state conditions. The experiments covered a wide range of engine operating parameters such as injection pressures, injection timing, and EGR ratios. The spline function was found to be the most effective method for smoothing both the steady state pressure trace and the transient state pressure trace.</div>
Inside Cover: Manipulating the Expression Rate and Enantioselectivity of an Epoxide Hydrolase by Using Directed Evolution (ChemBioChem 10/2011) (2011)

The inside cover picture shows the increase in expression efficiency and stereoselectivity of the epoxide hydrolase ANEH induced by directed evolution. Also illustrated is the complementary construct of fused ANEH linker α-fragments in the pMALC4X plasmid used in blue-colony screening. For more details, see the paper by M. T. Reetz and H. Zheng on p. 1529 ff.
Research on Spacing Effect of The Construction of Shield Tunnels undercrossed Existing Tunnels at Close Distance (2018)

With the increasingly dense distribution of urban subway network, line crossing will inevitably occur. The phenomenon of new tunnels passing through existing tunnels is becoming more and more common. Shield tunneling will inevitably disturb the surrounding soil and redistribute the stress and displacement fields, resulting in the deformation and additional stress of existing subway tunnels. The new tunnel should have strict requirements for the deformation control of existing tunnels and surrounding rocks. The spacing effect of new tunnels under existing tunnels can ensure the safety of new tunnels and the operation safety of existing shield tunnels, which has become an important problem to be solved urgently. On the basis of theoretical analysis, this paper takes a new shield tunnel under the existing tunnel in Xuzhou City as the backing, carries out numerical simulation of the new and old tunnel under different clearance by finite element software, and studies the influence of the new tunnel on the existing tunnel when the tunnel is constructed with different spacing of 1.5m, 0.5D, 1D, 1.5D, 2D and 3D. It is concluded that the reasonable distance between the new tunnel and the existing tunnel should be controlled between 1D and 1.5D under the circumstance of the surrounding environment, the permission of the new tunnel line and the economical and reasonable conditions.
Angiotensin II Type 1 Receptor mRNA Levels in the Brains of Normotensive and Spontaneously Hypertensive Rats (1993)

The type 1 angiotensin II (AII) receptor (AT1-R) has been implicated in the physiological actions mediated by AII in the brain. In view of the reported hyperactivity of the brain AII system in the spontaneously hypertensive rat (SHR), we compared the expression of AT1-R mRNAs in the brains of normotensive [Wistar Kyoto (WKY)] and SHR animals. Northern blot analysis showed about three- and approximately 20-fold increases in the levels of AT1-R mRNAs from the hypothalamus and brainstem areas, respectively, of the SHR compared with the WKY rat brain. This was attributable to greater levels of both AT1A- and AT1B-R mRNA subtypes in these areas from the SHR. These observations suggest that increased AII receptor levels in SHR brain may, in part, be a result of increased expression of the AT1-R gene.
vacanciers attendez le 1er juiilet pour telephoner (2012)

info:eu-repo/semantics/published
Nuclear Magnetic Resonance Titration Curves of Histidine Ring Protons (1973)

Abstract The histidine ring proton nuclear magnetic resonance titration curves of chemical shift versus pH of ribonuclease S and ribonuclease A are almost identical. This indicates a close similarity in the electronic environments of the histidine residues in these two enzymes. In addition to the main inflection in these curves due to the imidazole group titration, an acid inflection in the pH range 4 to 5 was observed in three of the four NMR titration curves of ribonuclease S. Similar inflections have previously been observed in ribonuclease A. Addition of phosphate ion to ribonuclease A results in changes in the NMR titration curves of the two imidazole C2 proton resonances, which are thought to correspond to the two active site histidine residues. The apparent pKa values of these two imidazole groups increase with addition of phosphate, while the pKa values of the acid inflections in these curves decrease slightly. These changes produce an increased separation of the imidazole and acid inflections and result in a pronounced asymmetry in the NMR titration curves. The pKa values determined for the acid inflection do not correspond to an ionization of the phosphate group. The effects of sulfate ion are similar to those of phosphate. The results support the hypothesis that the acid perturbations in these NMR titration curves arise from intramolecular interactions of the imidazole groups with nearby carboxyl groups.
Enhancing the binding properties of a conformationally rigid podand ionophore (1992)

Stereospecific functionalization of a conformationally rigid podand yields new ionophores having binding properties comparable to those of the macrocyclic crown ethers.
cDNA-RDA of genes expressed in fetal and adult lungs identifies factors important in development and function (2000)

The identification of genetic factors important in lung development and function will help in understanding the underlying molecular mechanisms of respiratory disease. Representational difference analysis of cDNA (cDNA-RDA) is a PCR-based subtractive enrichment procedure for the isolation of differentially expressed genes. We performed cDNA-RDA and isolated genes expressed more abundantly in fetal and adult lungs. Fifty-four clones potentially representing genes with higher transcript levels in the fetal lung were sequenced. Sequence similarity searches indicated that these clones included 12 known genes, a discoidin-like domain-containing gene, six expressed sequence tags (ESTs), and one novel sequence. Fifty-six clones potentially representing genes expressed more abundantly in the adult lung were also cloned and sequenced. Of these, 16 known human genes were represented along with two sequences significantly similar to known mouse genes and two novel sequences. Several of these known genes are implicated in stress response and lung protection. Thus cDNA-RDA was successfully used to isolate known and novel differentially expressed genes, which putatively play an important role in human lung development.
Clinically Significant Gastrointestinal Bleeding in Critically Ill Patients in An Era of Prophylaxis (2000)

In an intensive care unit where stress prophylaxis is widely used, clinically important gastrointestinal bleeding is uncommon. Further study is needed to define the optimal prophylaxis regimen and the role for its selective use in high-risk patients.
Effects of using superresolution techniques in ISAR imagery (2003)

Resolution in inverse synthetic aperture radar (ISAR) imagery is limited by the bandwidth of the transmitted signal and the total aspect change. Alternative spectral analysis techniques have been used in ISAR imaging in order to alleviate the loss of resolution. These superresolution techniques have been tested in radar data that has been previously interpolated from a polar format to Cartesian coordinates so that rotational motion is not a factor to consider. However, it is known that when a target rotates only a few degrees, the point scatterers that form the image do not migrate considerably and appear focused, thus the motion compensation step in the formation of a radar image can be avoided. Superresolution techniques are applied to the case when no prior interpolation is done. It is shown that superresolution techniques applied to polar reformatted data yields satisfactory results regardless of the total aspect change experienced by a target and the resolution improvement factor is only bounded by the factor of the specific method used.
Projet moteurgaro : mise en oeuvre en exploitations sucrières de moteurs à injection d'éthanol, Réunion et Maurice, septembre 1982 (1982)

Le procédé garo constitue une innovation authentique comportant des potentialités importantes pour la valorisation des carburants présentant des caractéristiques d'inflammation type alcool. Ce document propose un programme de recherche-expérimentation sur le terrain à la Réunion et à Maurice et présente le budget nécessaire à sa réalisation
General conditions for intrinsic optical bistability at the atomic and molecular scale: An effective spin-Hamiltonian approach (2002)

A model for intrinsic optical bistability is presented in the case of systems that can be described as two weakly interacting subsystems embedded in a matrix M. This model is based on an effective spin-Hamiltonian and a semiclassical density-matrix approach. It is shown that optical bistability should occur when the interaction between the two subsystems fluctuates more rapidly than the characteristic time of the interaction. The validity of the model is demonstrated in the case of bistable electron magnetic resonance, involving real spins. It is also shown that this model provides a semiquantitative explanation of intrinsic optical bistability for ${\mathrm{Yb}}^{3+}$ pairs in ${\mathrm{CsCdBr}}_{3}$ matrix.
Synthesis and Degradation of Cyclic ADP-Ribose by NAD Glycohydrolases (1993)

Cyclic adenosine diphosphoribose (cADPR), a recently discovered metabolite of nicotinamide adenine dinucleotide (NAD), is a potent calcium-releasing agent postulated to be a new second messenger. An enzyme that catalyzes the synthesis of cADPR from NAD and the hydrolysis of cADPR to ADP-ribose (ADPR) was purified to homogeneity from canine spleen microsomes. The net conversion of NAD to ADPR categorizes this enzyme as an NAD glycohydrolase. NAD glycohydrolases are ubiquitous membrane-bound enzymes that have been known for many years but whose function has not been identified. The results presented here suggest that these enzymes may function in the regulation of calcium homeostasis by the ability to synthesize and degrade cADPR.
Imidazole Catalysis. II. The Reaction of Substituted Imidazoles with Phenyl Acetates in Aqueous Solution (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImidazole Catalysis. II. The Reaction of Substituted Imidazoles with Phenyl Acetates in Aqueous SolutionThomas C. Bruice and Gaston L. SchmirCite this: J. Am. Chem. Soc. 1958, 80, 1, 148–156Publication Date (Print):January 1, 1958Publication History Published online1 May 2002Published inissue 1 January 1958https://pubs.acs.org/doi/10.1021/ja01534a040https://doi.org/10.1021/ja01534a040research-articleACS PublicationsRequest reuse permissionsArticle Views1299Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts