gebhart/patrepeval huggingface dataset:
Kinetics and mechanism for the reaction between alkyl hydroperoxides and tetranitromethane (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and mechanism for the reaction between alkyl hydroperoxides and tetranitromethaneWilliam F. Sager and John C. HoffsommerCite this: J. Phys. Chem. 1969, 73, 12, 4155–4162Publication Date (Print):December 1, 1969Publication History Published online1 May 2002Published inissue 1 December 1969https://pubs.acs.org/doi/10.1021/j100846a021https://doi.org/10.1021/j100846a021research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Do Electronic Health Records Help or Hinder Medical Education? (2009)

Many countries worldwide are digitizing patients' medical records. What impact will these electronic health records have upon medical education? This debate examines the threats and opportunities.
Hypertensive encephalopathy (2003)

The authors describe three patients with refractory temporal lobe epilepsy (TLE) following an episode of hypertensive encephalopathy as their only identified antecedent event. All patients had typical MR features of hippocampal sclerosis (HS), and the two operated cases had typical HS histology and became seizure-free postoperatively. These cases suggest that hypertensive encephalopathy may be a rare form of initial precipitating injury, leading to TLE and HS.
Compounds Contributing to the “Beany” Odor of Aqueous Solutions of Soy Protein Isolates (1999)

ABSTRACT Using gas chromatography/olfactometry (GCO), major odors from the headspace of aqueous solutions of soy protein isolates were evaluated. Many corresponding odorants were identified by correlating GCO with GC/mass spectrometry (MS) on two separate stationary phases followed by comparing retention times, mass spectra, odor descriptions and odor intensities with authentic standards. Based on aroma extract dilution analyses, the most powerful odorants (strongest and most volatile first) were (1) dimethyl trisulfide, (2) trans,trans ‐2,4‐ decadienal, (3) an unidentified burnt soy sauce‐like odor, (4) 2‐pentyl pyridine, (5) trans,trans ‐2,4‐nonadienal, (6) hexanal, (7) an unidentified charred sweaty feet‐like odor, (8) acetophenone, and (9) 1‐octen‐3‐one. This is the first reported occurrence of dimethyl trisulfide in soy protein isolates.
Lipoplexes (2003)

Abstract The sections in this article are Introduction DNA Lipoplexes Composition Nanostructure and Microstructure Equilibrium Morphology Nonequilibrium Morphology Lipoplex Size Lipofection Efficiency In Vitro In Vivo ODN Lipoplexes si RNA Lipoplexes Acknowledgments
Cardiac rehabilitation delivery in low/middle-income countries (2019)

CR is only available in 40% of LMICs, but where offered is fairly consistent with guidelines. Governments should enact policies to reimburse CR so patients do not pay out-of-pocket.
Structural stability of BeH2 at high pressures (2003)

The electronic structure and structural stability of BeH2 are studied using first-principles density-functional calculation. The calculated structural parameters for α-BeH2 at the equilibrium volume are in very good agreement with experiments. At higher pressures α-BeH2 successively undergoes four structural transitions: (i) α- to β-BeH2 at 7.07 GPa; (ii) β- to γ-BeH2 at 51.41 GPa; (iii) γ- to δ-BeH2 at 86.56 GPa; and (iv) δ- to ε-BeH2 at 97.55 GPa [an effective two-phase (γ and δ) region is found at 73.71–86.56 GPa]. Density of states studies reveal that BeH2 remains insulating up to 100 GPa whereupon anomalous changes are seen in the band-gap region with increasing pressure.
Diurnal Variation of Optical Coherence Tomography Measurements of Static and Dynamic Anterior Segment Parameters (2017)

No significant diurnal variation of static or dynamic anterior segment parameter measurements was detected in the light and dark. Diurnal variation of these parameters does not regularly occur in young, healthy eyes.
Process for the production of fatty acid alkyl esters by integrating fermentation and esterification (2010)

Axe 4 Biotechnologie microbienne et enzymatique des lipides et des agropolymères. Contact: erdubio@supagro.inra.fr
Computer Vision and Color Measurement Techniques for Inline Monitoring of Cheese Curd Syneresis (2007)

Optical characteristics of stirred curd were simultaneously monitored during syneresis in a 10-L cheese vat using computer vision and colorimetric measurements. Curd syneresis kinetic conditions were varied using 2 levels of milk pH (6.0 and 6.5) and 2 agitation speeds (12.1 and 27.2 rpm). Measured optical parameters were compared with gravimetric measurements of syneresis, taken simultaneously. The results showed that computer vision and colorimeter measurements have potential for monitoring syneresis. The 2 different phases, curd and whey, were distinguished by means of color differences. As syneresis progressed, the backscattered light became increasingly yellow in hue for circa 20 min for the higher stirring speed and circa 30 min for the lower stirring speed. Syneresis-related gravimetric measurements of importance to cheese making (e.g., curd moisture content, total solids in whey, and yield of whey) correlated significantly with computer vision and colorimetric measurements.
Compatibility of paclitaxel injection vehicle with intravenous administration and extension sets (1994)

The compatibility of paclitaxel injection vehicle with a variety of i.v. administration and extension sets was studied in terms of the amount of diethylhexyl phthalate (DEHP) leached from the sets. Test solutions of paclitaxel injection vehicle corresponding to paclitaxel injection 0.3 and 1.2 mg/mL were prepared in polyolefin bags of 5% dextrose injection. The solutions were delivered in triplicate over 24 hours through 26 models of administration sets and 24 models of extension sets and collected in glass containers. Portions were removed after delivery and analyzed in duplicate for DEHP concentration by high-performance liquid chromatography. All the extension sets were compatible with paclitaxel injection vehicle. Most of the administration sets were also compatible. However, two administration sets were incompatible with paclitaxel vehicle corresponding to either drug concentration, and five sets were incompatible with the vehicle simulating the high (1.2-mg/mL) concentration. Some of the incompatible sets were labeled as not containing polyvinyl chloride (PVC). Solutions of paclitaxel vehicle leached DEHP from administration sets containing PVC and from some sets labeled as not containing PVC.
Zinc(II) Interactions with Brain-Derived Neurotrophic Factor N-Terminal Peptide Fragments: Inorganic Features and Biological Perspectives (2013)

Brain-derived neurotrophic factor (BDNF) is a neurotrophin essential for neuronal differentiation, growth, and survival; it is involved in memory formation and higher cognitive functions. The N-terminal domain of BDNF is crucial for the binding selectivity and activation of its specific TrkB receptor. Zn(2+) ion binding may influence BDNF activity. Zn(2+) complexes with the peptide fragment BDNF(1-12) encompassing the sequence 1-12 of the N-terminal domain of BDNF were studied by means of potentiometry, electrospray mass spectrometry, NMR, and density functional theory (DFT) approaches. The predominant Zn(2+) complex species, at physiological pH, is [ZnL] in which the metal ion is bound to an amino, an imidazole, and two water molecules (NH2, N(Im), and 2O(water)) in a tetrahedral environment. DFT-based geometry optimization of the zinc coordination environment showed a hydrogen bond between the carboxylate and a water molecule bound to zinc in [ZnL]. The coordination features of the acetylated form [AcBDNF(1-12)] and of a single mutated peptide [BDNF(1-12)D3N] were also characterized, highlighting the role of the imidazole side chain as the first anchoring site and ruling out the direct involvement of the aspartate residue in the metal binding. Zn(2+) addition to the cell culture medium induces an increase in the proliferative activity of the BDNF(1-12) peptide and of the whole protein on the SHSY5Y neuroblastoma cell line. The effect of Zn(2+) is opposite to that previously observed for Cu(2+) addition, which determines a decrease in the proliferative activity for both peptide and protein, suggesting that these metals might discriminate and modulate differently the activity of BDNF.
Synergistic Activation of Toll-Like and NOD Receptors by Complementary Antigens as Facilitators of Autoimmune Disease: Review, Model and Novel Predictions (2020)

Persistent activation of toll-like receptors (TLR) and nucleotide-binding oligomerization domain-containing proteins (NOD) in the innate immune system is one necessary driver of autoimmune disease (AD), but its mechanism remains obscure. This study compares and contrasts TLR and NOD activation profiles for four AD (autoimmune myocarditis, myasthenia gravis, multiple sclerosis and rheumatoid arthritis) and their animal models. The failure of current AD theories to explain the disparate TLR/NOD profiles in AD is reviewed and a novel model is presented that explains innate immune support of persistent chronic inflammation in terms of unique combinations of complementary AD-specific antigens stimulating synergistic TLRs and/or NODs. The potential explanatory power of the model is explored through testable, novel predictions concerning TLR- and NOD-related AD animal models and therapies.
Effects of internet-based pain coping skills training before home exercise for individuals with hip osteoarthritis (HOPE trial): a randomised controlled trial (2018)

This assessor-, therapist-, and participant-blinded randomised controlled trial evaluated the effects of an automated internet-based pain coping skills training (PCST) program before home exercise for people with clinically diagnosed hip osteoarthritis. One hundred forty-four people were randomised to either the PCST group or the comparator group. In the first 8 weeks, the PCST group received online education and PCST, whereas the comparison group received online education only. From weeks 8 to 24, both groups visited a physiotherapist 5 times for home exercise prescription. Assessments were performed at baseline, 8, 24, and 52 weeks. Primary outcomes were hip pain on walking (11-point numerical rating scale) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) at 24 weeks. Secondary outcomes were other measures of pain, quality-of-life, global change, self-efficacy, pain coping, pain catastrophizing, depression, anxiety, stress, physical activity, and adverse events. Primary outcomes were completed by 137 (95%), 131 (91%), and 127 (88%) participants at 8, 24, and 52 weeks, respectively. There were no significant between-group differences in primary outcomes at week 24 (change in: walking pain [mean difference 0.5 units; 95% confidence interval, -0.3 to 1.3] and function [-0.9 units; 95% confidence interval, -4.8 to 2.9]), with both groups showing clinically relevant improvements. At week 8, the PCST group had greater improvements in function, pain coping, and global improvement than comparison. Greater pain coping improvements persisted at 24 and 52 weeks. In summary, online PCST immediately improved pain coping and function but did not confer additional benefits to a subsequent exercise program, despite sustained pain coping improvements.
Evidence of Hofstadter's Fractal Energy Spectrum in the Quantized Hall Conductance (2001)

The energy spectrum of a two-dimensional electron system in a perpendicular homogeneous magnetic field and a weak lateral superlattice potential with square symmetry is composed of Landau bands with recursive internal subband structure. The Hall conductance in the minigaps is anticipated to be quantized in integer multiples of e(2)/h that vary erratically from minigap to minigap in accordance with a Diophantine equation. Hall measurements on samples with the requisite properties uncover this long searched for evidence of Hofstadter's butterflylike energy spectrum.
Prevalence of periodical leg movements in patients with narcolepsy in an outpatient facility in São Paulo (2014)

Studies have pointed out that approximately 50-60% of narcolepsy patients may demonstrate higher prevalence of periodical leg movements. However, we highlight that the prevalence studies and the effects of periodical leg movements in patients with narcolepsy are limited and with conflicting results. The objective of this study was that of describing and discussing the prevalence of periodical leg movements in patients with narcolepsy in the outpatient facility of diurnal excessive sleepiness of the Federal University of São Paulo, Brazil. We revised 59 files of patients with the clinical and electrophysiological diagnosis of narcolepsy according to the American Academy of Sleep Medicine. Of these 59 cases of patients with narcolepsy, 12 (20.3%) demonstrated periodical leg movements. Thirty five patients (59.3%) had history of cataplexy and 38 patients (64.4%) had the presence of the allele HLA-DQB1⁎0602. There was a higher prevalence of periodical leg movements in patients with cataplexy (p<0.0001) and in patients with the presence of the allele HLA-DQB1⁎0602 (p<0.0001). Our study characterized the higher prevalence of periodical leg movement in patients with narcolepsy, mainly in patients with cataplexy and with the presence of the allele HLA-DQB1⁎0602.
Using electroactive polymers to simulate the sense of light touch and vibration in a virtual reality environment (2011)

Virtual reality simulators seek to immerse users in realistic interactive environments. However, at present, while several provide kinesthetic feedback, most lack tactile feedback. Current means of tactile feedback do not generate enough force to the digits, deliver a non-intuitive sense of feedback and are too large or heavy to be used in hand-worn configurations. The tactile feedback system developed herein uses electroactive polymers to create light touch and vibratory sensation to the fingertips, and DC motors to constrict the distal digit. In essence, when current is passed through the electroactive polymer in the shape of a cantilever (7 mm long by 19 mm wide), it bends on its long axis, providing a forces of 25 mN. Vibratory feedback is created by varying input voltage with a sinusoidal waveform. To generate fingertip constriction, two DC motors cinch a wire attached to a rubber thimble. These hardware components are controlled by a computer running X3D software, an ISO standard for representing 3D graphics, which affords a virtual environment for the tracking of one's hand. Upon contact with a virtual object, the actuators generate prescribed forces or vibrations. With this setup, a series of human-subjects experiments will be conducted whereby the task is to contact and differentiate virtual spheres of differing stiffness. Experiment 1 will test the electroactive polymers to determine the threshold for recognizing light touch, Experiment 2 will test vibrational discrimination, and Experiment 3 will test the ability of the user to differentiate constriction forces.
Preparative Bioorganic Chemistry, XI Preparation of the Enantiomers of Paraconic Acid Employing Lipase‐Mediated Asymmetric Hydrolysis of Prochiral Diacetates as the Key Step (1989)

Abstract ( S )‐(‐)‐Paraconic acid ( 1 ) was prepared from 2‐(acetoxymethyl)‐3‐phenylpropyl acetate ( 4 ) by its asymmetric hydrolysis with pig pancreatic lipase as the key step. Similarly, ( R )‐(+)‐ 1 was prepared from 2‐(acetoxymethyl)‐4‐pentenyl acetate ( 2 ) by its asymmetric hydrolysis with lipase MY.
Fast linear expected-time alogorithms for computing maxima and convex hulls (1990)

This paper examines the expected complexity of boundary problems on a set ofN points inK-space. We assume that the points are chosen from a probability distribution in which each component of a point is chosen independently of all other components. We present an algorithm to find the maximal points usingKN + O (N1−1/K log1/K N) expected scalar comparisons, for fixedK≥ 2. A lower bound shows that the algorithm is optimal in the leading term. We describe a simple maxima algorithm that is easy to code, and present experimental evidence that it has similar running time. For fixedK ≥ 2, an algorithm computes the convex hull of the set in 2KN + O(N1−1/K log1/KN) expected scalar comparisons. The history of the algorithms exhibits interesting interactions among consulting, algorithm design, data analysis, and mathematical analysis of algorithms.
Multi-channel OCT enabling multi-directional in vivo imaging in the human retina (2017)

We investigate the directional scattering properties of the healthy human retina in vivo using multiple reflectivity scans of the same retinal location acquired simultaneously by multi-channel optical coherence tomography (OCT).
Stable and unstable isotopes in catalytic research (1950)

The first page of this article is displayed as the abstract.
Driver's Characteristics And Performances When Using In-vehicle Navigation System (2005)

This paper describes driver characteristics and performances when using an in-vehicle information and navigation system in experiments through simulator and field experiments. Results imply that the navigation system decreased the workload of route selection in comparison with the paper map.
Membrane interaction and modulation of gene expression by tumor promoters. (1983)

Phorbol ester tumor promoters bind to specific cellular receptors (probably protein kinase C) and modulate membrane structure and function and gene expression of target cells. Using cell culture systems, we are studying the interaction of phorbol esters with the cellular membrane and subsequent modulation of gene expression. Our recent results can be summarized as follows: 1) specific binding of phorbol esters to mammalian cells can be inhibited by a human placental factor, which we have partially purified and characterized. 2) Phorbol ester tumor promoters reversibly inhibit intercellular communication, as measured by electrical coupling and dye transfer between cultured cells, suggesting that they inhibit both ionic and molecular transfer between cells. 3) In vitro transformation of Balb/c 3T3 cells results in blockage of intercellular communication between normal and transformed cells, indicating that blocked intercellular communication may play a role in cell transformation. 4) 12-O-Tetradecanoylphorbol-13-acetate (TPA) can continuously inhibit differentiation and globin gene expression in Friend erythroleukemia cells, without affecting their growth rate, for about 3 years. Both globin gene expression and terminal differentiation of Friend cells occur again upon removal of TPA from culture medium during such long-term culture.
Muscle pH, rigor mortis and blood variables in Atlantic salmon transported in two types of well‐boat (2010)

Two systems for transporting live salmon (Salmo salar) were compared in terms of their effects on blood variables, muscle pH and rigor index: an 'open system' well-boat with recirculated sea water at 13.5 degrees C and a stocking density of 107 kg/m3 during an eight-hour journey, and a 'closed system' well-boat with water chilled from 16.7 to 2.1 degrees C and a stocking density of 243.7 kg/m3 during a seven-hour journey. Groups of 10 fish were sampled at each of four stages: in cages at the farm, in the well-boat after loading, in the well-boat after the journey and before unloading, and in the processing plant after they were pumped from the resting cages. At each sampling, the fish were stunned and bled by gill cutting. Blood samples were taken to measure lactate, osmolality, chloride, sodium, cortisol and glucose, and their muscle pH and rigor index were measured at death and three hours later. In the open system well-boat, the initial muscle pH of the fish decreased at each successive stage, and at the final stage they had a significantly lower initial muscle pH and more rapid onset of rigor than the fish transported on the closed system well-boat. At the final stage all the blood variables except glucose were significantly affected in the fish transported on both types of well-boat.
Trellis-based deconvolution of ultrasonic echoes (2002)

A novel deconvolution algorithm is proposed for ultrasonic (US) echoes from layered materials. The basic idea is to model the reflectivity functions as well-defined sparse sequences and to perform a maximum-likelihood (ML) sequence estimation over the set of these sequences. A tree-based sequence estimation exhibits an exponentially growing complexity, but can in this case be converted into a trellis-based estimation with a linearly growing complexity. Deconvolution results of measured US-signals are given to confirm the theory. They demonstrate that the a priori knowledge introduced by the reduction of the solution space improves the deconvolution considerably.
Conformational Transition in Polypeptide Elongation Factor Tu as Revealed by Electron Spin Resonance (1974)

Abstract The conformational transition in the polypeptide elongation factor Tu (EF-Tu) associated with the ligand change from GTP to GDP has been suggested from the differences in their reactivity toward aminoacyl-tRNA. We have examined the structural changes in these two forms of EF-Tu near the active site interacting with aminoacyl-tRNA using the protein spin-labeled with N-ethylmaleimide analogues. It was found that, among three sulfhydryl groups of EF-Tu, the one essential for the binding of aminoacyl-tRNA could be labeled specifically in the presence of GDP. The electron spin resonance spectra of the spin-labeled EF-Tu GDP complex markedly changed when its GDP moiety was replaced by GTP by incubation with phosphoenolpyruvate and pyruvate kinase. The spectral changes unequivocally demonstrate that a reversible conformational change does occur in EF-Tu near the active site induced by the ligand conversion from GDP to GTP.
Intracellular degradation of beta4 integrin in lethal junctional epidermolysis bullosa with pyloric atresia (2004)

We report for the first time a homozygous in-frame deletion in the ITGB4 gene. Our results suggest that the deletion of amino acids R59-A69 interferes with the biosynthetic folding of the protein, leading to a rapid degradation of the mutated beta4 chains. These findings provide new insight into the pathogenic effects of mutations affecting different functional domains of the beta4 integrin molecule and their prognostic implications in PA-JEB patients.