gebhart/patrepeval huggingface dataset:
Fragmentation Chemistry of [Met-Gly]<sup>•+</sup>, [Gly-Met]<sup>•+</sup>, and [Met-Met]<sup>•+</sup> Radical Cations (2013)

Radical cations [Met-Gly](•+), [Gly-Met](•+), and [Met-Met](•+) have been generated through collision-induced dissociation (CID) of [Cu(II)(CH3CN)2(peptide)](•2+) complexes. Their fragmentation patterns and dissociation mechanisms have been studied both experimentally and theoretically using density functional theory at the UB3LYP/6-311++G(d,p) level. The captodative structure, in which the radical is located at the α-carbon of the N-terminal residue and the proton is on the amide oxygen, is the lowest energy structure on each potential energy surface. The canonical structure, with the charge and spin both located on the sulfur, and the distonic ion with the proton on the terminal amino group, and the radical on the α-carbon of the C-terminal residue have similar energies. Interconversion between the canonical structures and the captodative isomers is facile and occurs prior to fragmentation. However, isomerization to produce the distonic structure is energetically less favorable and cannot compete with dissociation except in the case of [Gly-Met](•+). Charge-driven dissociations result in formation of [b(n) - H](•+) and a(1) ions. Radical-driven dissociation leads to the loss of the side chain of methionine as CH3-S-CH=CH2 producing α-glycyl radicals from both [Gly-Met](•+) and [Met-Met](•+). For [Met-Met](•+), loss of the side chain occurs at the C-terminal as shown by both labeling experiments and computations. The product, the distonic ion of [Met-Gly](•+), NH3 (+)CH(CH2CH2SCH3)CONHCH(•)COOH dissociates by loss of CH3S(•). The isomeric distonic ion NH3 (+)CH2CONHC(•)(CH2CH2SCH3)COOH is accessible directly from the canonical [Gly-Met](•+) ion. A fragmentation pathway that characterizes this ion (and the distonic ion of [Met-Met](•+)) is homolytic fission of the Cβ-Cγ bond to lose CH3SCH2(•).
SURVEY AND SETTING OUT OF TOWNSHIPS AND TOWNPLANNING LAY-OUTS (1934)

General.—The two main causes bringing the Surveyor's work into association with that of the Town-Planning Engineer are development of new areas, arising from industrial, residential, or other necessity for expansion, and the replanning of congested or badly laid out districts in existing towns. The initiative in such schemes may come from a Local Authority, private enterprise, or public representations.
An Acoustic Microscope for Surface Characterization (1981)

Acoustic microscopy has been used recently for nondestructive thickness measurements of surface layers. The approach is based upon the thickness dependence of the surface wave velocity in a layered medium. Using an acoustic material signature from a focused beam microscopy as described in the literature, one can determine the surface-wave velocity. This technique also has the potential of providing information on coating defects and surface adhesion. An experimental facility is being established at LLNL for the characterization of the relatively thick coatings that are protecting surfaces from corrosion and erosion. Thicknesses in the range of 0.01 to 0.25-mm require an operating frequency between 5 and 200-MHz. An experimental system capable of operation at discrete frequencies between these limits has been constructed and initially used to obtain the acoustic material signature of aluminum on beryllium from which we deduce the surface wave velocity. This measured velocity compares favorably with calculated results.
Functional changes of dendritic cells in hypersensivity reactions to amoxicillin (2010)

A better understanding of dendritic cell (DC) involvement in responses to haptenic drugs is needed, because it represents a possible approach to the development of an in vitro test, which could identify patients prone to drug allergies. There are two main DC subsets: plasmacytoid DC (pDC) and myeloid DC (mDC). β-lactams form hapten-carrier conjugates and may provide a suitable model to study DC behavior in drug allergy reactions. It has been demonstrated that drugs interact differently with DC in drug allergic and non-allergic patients, but there are no studies regarding these subsets. Our aim was to assess the functional changes of mDC and pDC harvested from an amoxicillin-hypersensitive 32-year-old woman who experienced a severe maculopapular exanthema as reflected in interleukin-6 (IL-6) production after stimulation with this drug and penicillin. We also aim to demonstrate, for the first time, the feasibility of this method for dendritic cell isolation followed by in vitro stimulation for studies of drug allergy physiopathology. DC were harvested using a double Percoll density gradient, which generates a basophil-depleted cell (BDC) suspension. Further, pDC were isolated by blood DC antigen 4-positive magnetic selection and gravity filtration through magnetized columns. After stimulation with amoxicillin, penicillin and positive and negative controls, IL-6 production was measured by ELISA. A positive dose-response curve for IL-6 after stimulation with amoxicillin and penicillin was observed for pDC, but not for mDC or BDC suspension. These preliminary results demonstrate the feasibility of this methodology to expand the knowledge of the effect of dendritic cell activation by drug allergens.
Effects of D-003, a Mixture of Sugarcane Wax Acids, on Platelet Aggregation in Hypercholesterolemic Patients (2011)

Increased platelet aggregation contributes to vascular risk. D-003, a mixture of high molecular weight sugarcane wax acids, has shown antiplatelet effects in experimental models and healthy volunteers. This randomised, double-blinded, placebo-controlled study investigated the effects of titrated doses of D-003 (5-20 mg/d) on platelet aggregation in hypercholesterolemic patients. After a 4-week baseline phase, 56 patients were randomised to D-003 5 mg/d or placebo. The doses were doubled every 15 days if arachidonic acid (AA)-induced platelet aggregation was not inhibited at least by 15%. AA (0.75 and 1.5 mmol/L) and collagen (1 microg/mL)-induced platelet aggregation, laboratory and physical safety indicators were assessed at baseline and every 15 days thereafter, when adverse events (AE) were also reported. No significant change of platelet aggregation was found in the placebo group. After 15, 30 and 45 on therapy, D-003 reduced platelet aggregation induced with both AA 0.75 mmol/L (18.1%, 19.0% and 30.3%, respectively) and AA 1.5 mmol/L (17.0%, 16.3% and 22.5%, respectively), and also collagen-induced platelet aggregation (26.6%, 20.8% and 29.4%) (p < 0.01 at days 15 and 30 versus placebo, p < 0.0001 at study completion). The mean inhibition of platelet aggregation with D-003 at day 15, at which all patients had received the lowest dose, was over 15%. Nineteen out of 28 D-003 randomised patients (67.9%) required dose titration to achieve such goal. At trial completion, the mean estimated dose was 11.6 mg/d. D-003 lowered low-density lipoprotein (22.0 %), total cholesterol (14.7%) and raised high-density lipoprotein-cholesterol (10.9%) (p < 0.0001 versus placebo). Six patients (2 placebo, 4 D-003) withdrew from the trial, none due to AE. D-003 did not modify the safety indicators with respect to placebo. Four patients (2 placebo, 2 D-003-treated) reported AE: pruritus and increased blood pressure (2 placebo) and rash and polyphagla (2 D-003). In conclusion, D-003 (5-20 mg/d) given as doses titrated every 15 days (5-20 mg/d) inhibited AA- and collagen-induced platelet aggregation in hypercholesterolemic patients and was well tolerated.
Anwendung von GOMS-Analysen und CogTool in der Design-Praxis (2010)

Kognitive Modellierung ist eine kostengunstige Methode betriebswirtschaftliche Anwendungen hinsichtlich ihrer Effizienz zu evaluieren und das Design solcher Anwendungen weiter zu optimieren. Wir untersuchen in diesem Beitrag mit KLMGOMS und CogTool zwei etablierte Methoden der kognitiven Modellierung in Bezug auf ihre Fahigkeit die Bearbeitungszeiten betriebswirtschaftlicher Arbeitsablaufe korrekt vorherzusagen. Die Ergebnisse zeigen, dass die mit Hilfe von CogTool generierten Vorhersagen genauer sind, als die aus einer GOMS-Analyse resultierenden Vorhersagen. Allerdings erfordert die Modellierung mit CogTool schon deutlich detailierter ausgearbeitetere Entwurfe als dies fur eine GOMS-Analyse notwendig ist. Aus diesen Ergebnissen konnen Empfehlungen fur den Einsatz und die Einschrankungen beider Methoden abgeleitet werden.
Nanotechnology for Improved Drug Bioavailability (2008)

This chapter contains sections titled: Introduction Nanotechnological Systems in Drug Delivery Delivery via Nanotechnologies Key Issues and Future Prospects References
Scalar quantization error analysis for image subband coding using QMFs (1992)

The authors analyze the coding errors due to quantization by explicitly incorporating a mathematical model for a Lloyd-Max quantizer into a quadrature mirror filter (QMF) splitting and reconstruction scheme (P. H. Westerink et al., 1988). This approach explicitly incorporates quantization errors into a QMF system by means of a quantizer model. This makes it possible to discriminate between different types of coding errors, such as the aliasing error. Other errors that can be distinguished are a QMF design error, a signal error, and a random error, which is uncorrelated with the original image. Both a mean-squared error calculation and a subjective judgment of the coding errors show that the aliasing errors can be neglected for filter lengths of 12 taps or more. The signal error determines the sharpness of the reconstructed image, while the random error is most visible in the flat areas.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hot Thermistor Anemometer for Finite Amplitude Stability Measurements (1965)

A device similar to a hot wire anemometer has been developed in which the wire is replaced with a thermistor. Niiler has presented a theory of the response of the anemometer to velocity gradients. Experimental calibration curves are presented here to show that Niiler's model explains the operational characteristics quite satisfactorily. The associated electronic circuitry is described and the design considerations which determine the magnitudes of the various adjustable parameters are discussed. This anemometer has been used to detect the onset of the various modes of secondary flow, the amplitude of the disturbances, their wavelengths, and their drift velocities. Both velocity and temperature fields may be measured.
A data‐driven approach for the structural analysis of hybrid metal‐plastic composites (2021)

Abstract The manufacturing of hybrid composites has an important impact on the final structural properties. Manufacturing induced defects influence the mechanical performance and thus need to be considered for the structural design. In this contribution, we present a data‐driven approach for the structural analysis of hybrid metal‐plastic composites. Based on numerical analyses, a surrogate model based on Proper Orthogonal Decomposition and Machine Learning is derived that can be implemented in early design optimizations.
Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of<i>Aspergillus fumigatus</i> (1992)

An Aspergillus fumigatus extracellular alkaline protease (ALP) which is an enzyme of the subtilisin family is a potential virulent factor of the fungus. The gene encoding ALP was isolated from a genomic library made from DNA of an A. fumigatus isolate. The nucleotide sequence of this gene was compared to that of a cDNA encoding A. oryzae ALP and to that of a cDNA from A. fumigatus encoding the mature ALP protein. Mature A. fumigatus ALP contains 282 amino acids and is encoded by three exons. The pre-proenzyme has a leader sequence of 121 amino acids.
A role for Arabidopsis growth-regulating factors 1 and 3 in growth–stress antagonism (2019)

Growth-regulating factors (GRFs) belong to a small family of transcription factors that are highly conserved in plants. GRFs regulate many developmental processes and plant responses to biotic and abiotic stimuli. Despite the importance of GRFs, a detailed mechanistic understanding of their regulatory functions is still lacking. In this study, we used ChIP sequencing (ChIP-seq) to identify genome-wide binding sites of Arabidopsis GRF1 and GRF3, and correspondingly their direct downstream target genes. RNA-sequencing (RNA-seq) analysis revealed that GRF1 and GRF3 regulate the expression of a significant number of the identified direct targets. The target genes unveiled broad regulatory functions of GRF1 and GRF3 in plant growth and development, phytohormone biosynthesis and signaling, and the cell cycle. Our analyses also revealed that clock core genes and genes with stress- and defense-related functions are most predominant among the GRF1- and GRF3-bound targets, providing insights into a possible role for these transcription factors in mediating growth-defense antagonism and integrating environmental stimuli into developmental programs. Additionally, GRF1 and GRF3 target molecular nodes of growth-defense antagonism and modulate the levels of defense- and development-related hormones in opposite directions. Taken together, our results point to GRF1 and GRF3 as potential key determinants of plant fitness under stress conditions.
Enhydrazine, 39. Einige stabile 1,4,5,6‐Tetrahydro‐1‐methylpyridazin‐3,4,5,6‐tetracarbonsäureester mit axialen Ester‐Gruppen (1988)

Abstract Aus Methylhydrazin und Acetylendicarbonsäureestern werden die Titelverbindungen 2a,b, 3a,b, 4a,b und 7a,b dargestellt. In 3a,b steht die Ester‐Gruppe an C‐6, in 2a,b stehen die beiden Ester‐Gruppen an C‐4 und C‐6 und in 4a,b und 7a,b die drei Ester‐Gruppen an C‐4 bis C‐6 axial. Die aus den NMR‐Spektren abgeleiteten Befunde werden für den kristallinen Zustand an 2b und 7a durch Strukturanalysen bestätigt.
Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4 (1989)

Chromosomal localization of the gene for human coagulation factor XI (F11) was determined by in situ hybridization using a genomic DNA probe which contained exons VIII, IX, and X of the gene. The results indicate that the gene is located at 4q35.
Prevalence and risk factors for HBV, HCV and HDV infections among injecting drug users from Rio de Janeiro, Brazil (1999)

Viral hepatitis constitutes a major health issue, with high prevalence among injecting drug users (IDUs). The present study assessed the prevalence and risk determinants for hepatitis B, C and D viruses (HBV, HCV and HDV) infections among 102 IDUs from Rio de Janeiro, Brazil. Serological markers and HCV-RNA were detected by enzyme immunoassay and nested PCR, respectively. HCV genotyping was determined by restriction fragment length polymorphism analysis (RFLP). HBsAg, anti-HBc and anti-HBs were found in 7.8, 55.8 and 24. 7% of IDUs, respectively. In the final logistic regression, HBV infection was independently associated with male homosexual intercourse within the last 5 years (odds ratio (OR) 3.1; 95% confidence interval (CI) 1.1-8.8). No subject presented anti-delta (anti-HD). Anti-HCV was detected in 69.6% of subjects, and was found to be independently associated with needle sharing in the last 6 months (OR 3.4; 95% CI 1.3-9.2) and with longer duration of iv drug use (OR 3.1; 95% CI 1.1-8.7). These data demonstrate that this population is at high risk for both HBV and HCV infection. Among IDUs from Rio de Janeiro, unprotected sexual intercourse seems to be more closely associated with HBV infection, whereas HCV is positively correlated with high risk injecting behavior. Comprehensive public health interventions targeting this population and their sexual partners must be encouraged.
Correlation Between Signals From Spaced Antennas of Stationary Meteorological Radars (2013)

This paper derives a general analytical expression for the correlation coefficient of signals received by two identical spaced antennas in a radar system used to detect meteorological phenomena such as rain and clouds. Such a correlation coefficient is found as a function of the relevant physical parameters, namely, distance between antennas (baseline distance), signal bandwidth, and antenna directivity. One of the antennas transmits the signal and receives its echoes from the scatterers, characterizing a monostatic radar, whereas the other antenna only receives these echoes, characterizing a bistatic radar. Our approach can be easily extended to nonidentical antennas.
Synthesis of Amides of Lysergic Acid<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Amides of Lysergic Acid1WILLIAM L. GARBRECHTCite this: J. Org. Chem. 1959, 24, 3, 368–372Publication Date (Print):March 1, 1959Publication History Published online1 May 2002Published inissue 1 March 1959https://doi.org/10.1021/jo01085a024Request reuse permissionsArticle Views801Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (635 KB) Get e-Alertsclose Get e-Alerts
The commuter : marginal member of the university community (1972)

There is no abstract available for this research paper.
A Queuing System with a Branching Process Arrival Stream, the Case of Short-Range Dependence (1993)

In a previous paper, we defined and studied a branching process input stream that can be used to model the organization of packets (in packetized communication) in messages. In this paper we derive a central result on the effect that such streams have on a packet switch (or queue) and further study one particular model (the case of so-called short-range dependence), where the distribution of the number of packets in a buffer can explicitly be found (albeit in the form of a transform). The solution to this particular model suggests an approximation for the average buffer content in the general case.
ChemInform Abstract: Enantiomerically Pure Isoxazolines (IV) via Addition of Nitrile Oxides to Chiral N‐Acryloyltoluene‐2α‐sultams (I). (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nuclear magnetic resonance studies of chloride binding to proteins (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNuclear magnetic resonance studies of chloride binding to proteinsThomas Bull, Jan Erik Norne, Petur Reimarsson, and Bjorn LindmanCite this: J. Am. Chem. Soc. 1978, 100, 15, 4643–4647Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ja00483a001https://doi.org/10.1021/ja00483a001research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Disease profile: idiopathic retroperitoneal fibrosis (2012)

Idiopathic retroperitoneal fibrosis is an uncommon but important disease that causes hardening of the tissues that surround the kidneys and major blood vessels. It can result in hydronephrosis and vascular aneurysms. Its diagnosis relies on radiography and treatment requires prompt surgical and drug interventions to halt its progression. Graham Cope gives an outline.
Spin Flipping through an Intrinsic Depolarizing Resonance by Strengthening It (1996)

We recently accelerated a polarized proton beam from 95 to 380 MeV through both the $G\ensuremath{\gamma}=2$ imperfection depolarizing resonance and the $G\ensuremath{\gamma}=7\ensuremath{-}{\ensuremath{\nu}}_{y}$ intrinsic depolarizing resonance. The imperfection resonance flipped the spin, while the intrinsic resonance initially caused partial depolarization. We then pulsed a vertical kicker magnet for about 500 ns to increase the beam's vertical betatron amplitude; this made the intrinsic resonance much stronger. By varying the strength and start time of the kicker, we observed a sharp spin flip due to the now very strong intrinsic depolarizing resonance.
Assessment of Combustion Mechanical Noise Separation Techniques on a V8 Engine (2017)

<div class="section abstract"><div class="htmlview paragraph">The noise radiated by an ICE engine results from a mixture of various complex sources such as combustion, injection, piston slap, turbocharger, etc. Some of these have been categorized as combustion related noise and others as mechanical noise. Of great concern is the assessment of combustion noise which, under some operating conditions, is likely to predominate over the other sources of noise. The residual noise, produced by various other sources, is commonly referred to as mechanical noise. Being able to extract combustion and mechanical noise is of prime interest in the development phase of the engine and also for diagnostic purposes.</div><div class="htmlview paragraph">This paper presents the application of combustion mechanical noise separation techniques on a V8 engine. Three techniques, namely the multi regression analysis, the classical Wiener filter and the cyclostationary (synchronous) Wiener filter, have been investigated. The techniques have been applied to microphone recordings measured at one meter distance from an engine running on a test bench. Reference in-cylinder pressure sensors have been instrumented and synchronously acquired together with the microphones. Strengths and weaknesses of the techniques are assessed and presented in the paper.</div><div class="htmlview paragraph">Finally a source separation technique is applied as a pre-processing step to the sound recordings measured on a microphone array. Sound source localization then allows to localize and quantify the combustion and mechanical sources of noise on the engine. This is illustrated with an application example.</div></div>
Macrocyclic Imidazolylboranes (2000)

Cycles, not chains: 1-imidazolylboranes exist in polymeric form as a consequence of donor/acceptor interactions. Through the use of suitable substituents and under high dilution tetrameric and pentameric macrocyclic imidazolylboranes were synthesized. The picture shows the structure of the tetrameric 4,5-dimethylimidazolylborane (black: C, gray: B, white: N).