gebhart/patrepeval huggingface dataset:
Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. (1994)

The plexiform lesion in primary pulmonary hypertension is a glomeruloid structure forming channels in branches of the pulmonary artery. These lesions have been considered an abnormal growth of modified smooth muscle cells. We present immunohistochemical evidence in 10 cases of plexogenic pulmonary hypertension that the plexiform channels and the concentric obliterative arteriopathy associated with these channels represent abnormal growth of factor VIII-related antigen-positive endothelial cells. In addition, these cells strongly expressed vimentin, a growth- and differentiation-related intermediate filament. Morphologically and immunohistochemically, the lesions resembled the neovascularization associated with the brain tumor glioblastoma multiform. Furthermore, we noted an exclusively perivascular inflammatory cell infiltrate (but no vasculitis) in seven of the 10 cases with plexogenic arteriopathy composed of T cells, B cells, and macrophages. Our findings indicate that the plexiform lesion may result from a deregulated growth of endothelial cells. The presence of perivascular inflammatory cells suggested that cytokines and growth factors may further influence the development of the plexiform lesion.
SLEDAI-2K 10 days versus SLEDAI-2K 30 days in a longitudinal evaluation (2011)

The objective of the study was to evaluate SLEDAI-2K 30 days over time and to compare with the original SLEDAI-2K 10 days. Forty-one patients seen at The University of Toronto Lupus Clinic were followed at monthly intervals for 12 months. The SLEDAI-2K score was completed twice, once for a 10-day window and again for a 30-day window using the same definitions for the descriptors. Four hundred and nineteen patient-visits in 41 patients were recorded for both SLEDAI-2K for a 10-day and a 30-day window. One hundred and fifty-one patient-visits had a SLEDAI-2K activity score of 0 and 268 patient-visits had varying levels of disease activity in the range 1-15. In all but one patient-visit there was an agreement between the SLEDAI-2K 10 days and 30 days. SLEDAI-2K 30 days scores were concordant with SLEDAI-2K 10 days scores, both in patients in remission and in patients with a spectrum of disease activity levels followed monthly over 1 year. SLEDAI-2K 30 days was validated against SLEDAI-2K 10 days in a longitudinal evaluation over 1 year. We recommend the use of SLEDAI-2K 30 days in clinical studies and clinical trials.
Lightness constancy in 4-month-old infants: With and without a white anchoring point cue (2002)

Purpose. In adult literature, lightness constancy tends to breakdown when a white anchoring point is absent. Using real surfaces and real illuminants, Chien & Teller. (OSA 2001) reported that 4-month-old infants exhibit lightness constancy tested with a white background. Our present goal is to test whether infants show a reduced constancy when a white anchoring point cue is unavailable. Methods. The Forced-choice Novelty Preference technique was used to measure infants' novelty responses. The apparatus was a 24″′ 30″′ 24″ (L′H′D) testing chamber with a front 12″′ 12″ viewing window. The stimuli were real papers (Color-Aid grey series) of different reflectance (60% (light grey) and 20% (dark grey)), and were patterned as square smiley faces. The background reflectance was either 90% (white) in the white background (full cue) experiment, or 5 % (black) in the black background (no-anchoring cue) experiment. Two incandescent illuminants differing by about a factor of 3 were used. In the familiarization phase of each trial, infants were exposed to two identical smiley faces under one illumination. In the test phase, the illumination was either increased or decreased. The infant was presented one smiley face that had the same reflectance but with a novel luminance and another smiley face with a novel reflectance but the same luminance. If a white anchoring cue is important, we expect to see that infants show consistent preferences to the novel reflectance in the white background experiment, and no consistent preferences in the black background experiment. Results. In the white background experiment, infants looked more at the face with a novel reflectance (i.e. reflectance-matched face was seen as familiar), suggesting the presence of lightness constancy. In the black background condition, infants looked equally frequently at both faces (as if both faces appeared novel), suggesting a reduced constancy.
Use of Transposon-Transposase Complexes To Create Stable Insertion Mutant Strains of <i>Francisella tularensis</i> LVS (2004)

Francisella tularensis is a highly virulent zoonotic bacterial pathogen capable of infecting numerous different mammalian species, including humans. Elucidation of the pathogenic mechanisms of F. tularensis has been hampered by a lack of tools to genetically manipulate this organism. Herein we describe the use of transposome complexes to create insertion mutations in the chromosome of the F. tularensis live vaccine strain (LVS). A Tn5-derived transposon encoding kanamycin resistance and lacking a transposase gene was complexed with transposase enzyme and transformed directly into F. tularensis LVS by electroporation. An insertion frequency of 2.6 x 10(-8) +/- 0.87 x 10(-8) per cell was consistently achieved using this method. There are 178 described Tn5 consensus target sites distributed throughout the F. tularensis genome. Twenty-two of 26 transposon insertions analyzed were within known or predicted open reading frames, but none of these insertions was associated with the Tn5 target site. Analysis of the insertions of sequentially passed strains indicated that the transposons were maintained stably at the initial insertion site after more than 270 generations. Therefore, transformation by electroporation of Tn5-based transposon-transposase complexes provided an efficient mechanism for generating random, stable chromosomal insertion mutations in F. tularensis.
Mesenchymal stromal cells, from indifferent spectators to principal actors. Are we going to witness a revolution in the scenario of allograft and immune-mediated disorders? (2007)

Two different articles in this issue of the journal are focussed on mesenchymal stem cells (MSCs), with particular emphasis on their immune-regulatory properties and homing capacity, respectively.[1][1],[2][2] In the first study, Prevosto et al . demonstrate that short-term co-culture of human MSCs
Purification, properties and assay of <scp>d</scp>-ribulose 5-phosphate 3-epimerase from human erythrocytes (1983)

A direct assay procedure is described for D-ribulose 5-phosphate 3-epimerase (EC 5.1.3.1) which exploits differences in the c.d. spectra of substrate and product. The enzyme has been purified from human erythrocytes and was resolved by gel filtration and sucrose-density-gradient centrifugation into a major component of apparent Mr 45 000 and a minor component of Mr 23 000. Electrophoresis in sodium dodecyl sulphate gave a single component corresponding to Mr 23 000. Kinetic and sucrose-density-gradient centrifugation data indicate dissociation of the dimeric form of the enzyme into monomers of low specific activity; substrate favours the active dimeric form of the enzyme. At concentrations of the enzyme where both forms of the enzyme are present initial velocity data yielded a Hill plot with an interaction coefficient of approx. 2.0, indicating co-operative binding of substrate under these conditions.
Conceptual design of fuselage structure of very light jet aircraft (2010)

This paper describes a conceptual design of fuselage structure for very light jet aircraft by using CAD software as the design tool. Specific size and performance, the number of competing designs and the commonality of features with existing light jet aircraft are factors need to be considered in the design process. This conceptual design develops the first general size and configuration for a new light jet aircraft fuselage structure. The model of the fuselage structure is then undergoing engineering simulation programmed which is based on the finite element method. In this analysis, problems with multiple components are modeled by associating the geometry defining each component with the appropriate material model and specifying component interaction. Besides that, the load increments and convergence tolerance are continually adjusted to ensure an accurate solution is obtained.
Design for testability and diagnosis in a VLSI CMOS System/370 processor (1990)

This paper describes the design for testability and diagnosis in an IBM System/370 processor based on VLSI CMOS technology. The design incorporates built-in pseudorandom-pattern self-test and the boundary-scan technique. This technique permits the migration of tests generated for component-level to higher-level packages such as printed circuit boards and the system. Consequently, the expense for testing of higher-level packages can be reduced, and the test equipment for the processor can be simplified. The design also offers economical diagnostic capability.
A novel FEM-based dynamic framework for subdivision surfaces (1999)

Subdivision surfaces have been extensively used to model smooth shapes of arbitrary topology. Recursive subdivision on an userdefined initial control mesh generates a visually pleasing smooth surface in the limit. However, users have to carefully specify the initial mesh and/or painstakingly manipulate the control vertices at different levels of subdivision hierarchy to satisfy various functional and aesthetic requirements in the limit surface. This modeling drawback results from the lack of direct manipulation tools for the limit surface. In this paper, we integrate physicsbased modeling techniques with geometric subdivision methodology and present an unified approach for arbitrary subdivision schemes. Our dynamic framework permits users to directly manipulate the limit subdivision surface via physics-based ”force” tools. The key contribution of this unified approach is to formulate the smooth limit surface of any subdivision scheme as a single type of novel finite elements. The geometric and dynamic features of our subdivision-based finite elements depend on the subdivision scheme involved. We present our finite element method (FEM) and formulation for the modified butterfly and Catmull-Clark subdivision schemes, and further generalize our dynamic framework for any subdivision scheme. Our FEM-based approach significantly advances the state-of-the-art of physics-based geometric modeling because (1) our dynamic framework provides a universal physicsbased solution to any subdivision scheme beyond frequently-used and popular spline-like subdivision techniques; (2) we systematically devise a natural mechanism that allows users to intuitively deform any subdivision surface; (3) we represent the smooth limit surface of any subdivision scheme using a single type of novel subdivision-based finite elements. Our experiments demonstrate that the new unified FEM-based framework promises a greater potential of subdivision techniques for solid modeling, finite element analysis, and engineering design.
FLAIM: A Multi-level Anonymization Framework for Computer and Network Logs (2006)

FLAIM (Framework for Log Anonymization and Information Management) addresses two important needs not well addressed by current log anonymizers. First, it is extremely modular and not tied to the specific log being anonymized. Second, it supports multi-level anonymization, allowing system administrators to make fine-grained trade-offs between information loss and privacy/security concerns. In this paper, we examine anonymization solutions to date and note the above limitations in each. We further describe how FLAIM addresses these problems, and we describe FLAIM's architecture and features in detail.
Prepulse suppression in microwave pulse-compression cavities (1986)

It is possible to generate high-power microwave pulses with fast rise time by using resonant cavities to obtain power gain from pulse compression. In the usual case, especially when normal-conducting cavities are used, the principal output pulse from a pulse-compression device is preceded by a precursor signal that may be only 40 dB below the main pulse. For some applications this large a prepulse is unacceptable. We have developed a prototype normal-conducting, x-band, pulse-compression cavity in which the prepulse is suppressed by more than 70 dB. When this cavity is driven by a 20-kW source, output pulses with 200-kW peak power, 5-ns pulse width, and sub-nanosecond rise time can be obtained. We have also built an s-band cavity that has produced pulses of 5-ns width, 200-MW peak power, and under 3-ns rise time. The s-band cavity is typically driven at 5–10 MW and has a prepulse that can be more than 80 dB below the peak of the main pulse.
Type I Kounis syndrome variant: A case report and literature review (2018)

Kounis syndrome defined as the occurrence of acute coronary syndrome in the setting of allergic reaction due to mast cells activation and inflammatory mediators release that induces coronary vasospasm, plaque erosion, or even stent thrombosis. A 25-year-old postpartum female with asthma and recurrent episodes of chest pain was admitted with ST-segment elevation myocardial infarction in the setting of coronary artery spasms. The patient was started on calcium channel blockers and nitrite-based medication with no improvement. She was noted to have eosinophilia and initiation of corticosteroid-based regimen lead to resolution of chest pain episodes and normalization of eosinophilia. Kounis syndrome should be considered in young patients with chest pain. Coronary vasodilators are considered as the first-line of treatment. The use of corticosteroids has been described in the literature in severe or refractory cases.
A precision timing discriminator for high density detector systems (1992)

A zero-crossing discriminator that accurately determines the peak of a quasi-Gaussian waveform by differentiating it and detecting the resulting zero-crossing is described. Basically, it consists of a fast voltage comparator and two integrating networks: an RC section and an LR section used in a way that keeps the input impedance purely resistive. A time walk of 100 ps in an amplitude range exceeding 100:1 has been achieved for waveforms from 1.5 ns to 15 ns FWHM. An arming level discriminator is added to eliminate triggering by noise. Easily implemented in either monolithic or hybrid technology, the circuit is suitable for large multichannel detector systems where size and power dissipation are crucial. Circuit diagrams and typical measured data are also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
세계은행과 국제노동기구의 연금개혁전략 비교연구 : 한국에의 적용과 대응 (2001)

세계은행이 사적연금을 핵심 기둥으로하는 다주구조(多柱構造, mulipillar system)의 연금민영화개혁패러다임을 전파하기 시작한 이래로, 공적연금개혁논의는 새로운 차원에 접어들었다. 특히 ILO가 이에 대응해 개선된 공적연금을 기반으로하는 다층구조의 개혁전략을 선보임으로써, 그 어느때보다 공적연금개혁의 방향을 둘러싸고 논쟁이 활발하다. 세계은행이 한국과 구조조정차관을 주면서 공적연금에 대한 개혁을 조건화하고, 개혁모형을 권고함으로써 한국의 연금개혁논의도 새로운 국면에 접어들었다. 이논문은 한국의 공적연금체제의 지속가능한 발전을 위해서 구조적인 개혁이 필요한 시점에서, 두가지 목적을 가지고 씌여졌다. 첫째, 양대 국제기구의 연금개혁전략을 소개하고 비교평가한다. 둘째, 세계은행과의 구조조정협약의 결과 출범한 공·사연금제도개선실무위원회의 개혁안을 검토하여 세계은행은 물론 ILO가 제시하는 기본 모형들이 한국적 현실에서 어떻게 시도되고 있는지 살펴본다. 국내에서는 비교적 논의가 덜되고 있는, 그러나 세계은행과 ILO가 각각 새로운 개혁의 방향으로 제시하고 있는, 완전적립식 확정기여연금(fully funded defined contribution scheme)과 부과방식의 명목확정기여연금(pay-as-you-go notional defined contribution scheme)에 대한 보다 깊은 연구가 필요함을 본 논문은 마지막으로 지적한다.
WEB HISTORY ARCHIVE USING WEBBASE AND RCS IN LARGE SCALE WEB (2006)

Web information does not restrict space and time constraint and is used widely according to fast growth of web. However, if information used usefully in existing is deleted at one moment, problem that can not use web information more happens. To solve this problem, study about Web archive system was begun, and techniques to store deleted web information efficiently were suggested. But, existent techniques have shortcoming that did not consider entirely efficiency and conditionality of storage space. Because these techniques focused that store only web information. Therefore, we proposed web history archive system that can store efficiently and search web information that is up-dated in repository being based on WebBase. In this paper, proposed technique did not use special crawler for web history archive system. And it can reduce overhead for web information collection using WebBase. Also, it can store deleting web information using RCS. Thus, web information can be shared efficiently.
<i>RUNX1</i> gene mutation in primary myelodysplastic syndrome – the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome (2007)

Mutations of Runt-related transcription factor 1 (RUNX1) have been detected in patients with myelodysplastic syndrome (MDS). However, the prognostic implication of RUNX1 mutations in primary MDS is limited. The stage of the disease at which the mutations are acquired and whether they persist during the disease course also remain unclear. We analysed mutations of RUNX1 exons 3-8 in 132 patients with primary MDS and correlated the results with clinical features. Serial studies were performed during the follow-up period. Sixteen patients (12%) had RUNX1 mutations at the time of diagnosis. All RUNX1 mutations that were detected at diagnosis remained unchanged during the clinical course. Two other patients acquired RUNX1 mutations at leukaemic transformation 34 months and 35 months after the diagnosis of MDS. Patients with RUNX1 mutations at diagnosis had higher neutrophil counts and higher frequency of -7/7q deletion than those without. Furthermore, RUNX1 mutation was closely associated with a short overall survival (P = 0.039). This is the first report to demonstrate that RUNX1 mutation can not only be detected early at diagnosis but also acquired during disease progression and is associated with poor prognosis in patients with primary MDS. It may play a role in the development and progression of a subset of primary MDS.
Emerging Technologies for Materials and Chemicals from Biomass (1992)

There is a resurgence of interest in abundant, renewable, biomass resources as precursors for the production of polymeric materials, organic chemicals, and fuel. This heightened awareness and sense of urgency toward biomass utilization is driven by 1) environmental concerns, and the need for environmentally compatible polymers and chemicals. 2) the need to be weaned away from our dependance on non renewable imported petroleum feedstocks, and 3) utilization of the nation's abundant, renewable agricultural feedstocks in new non-food, non-feed uses.
Facile synthesis of a nanocomposite based on graphene and ZnAl layered double hydroxides as a portable shelf of a luminescent sensor for DNA detection (2014)

A hybrid graphene–ZnAl-LDH nanocomposite has been developed and used as a portable shelf of Ru(phen)<sub>3</sub>Cl<sub>2</sub>sensor to selectively discriminate DNA.
<i>N</i>'-<i>tert</i>-Butyl-<i>N</i>'-aroyl-<i>N</i>-(alkoxycarbonylmethyl)-<i>N</i>-aroylhydrazines, a novel nonsteroidal ecdysone agonist: syntheses, insecticidal activity, conformational, and crystal structure analysis (2001)

Seventeen N'-tert-butyl-N'-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazines were synthesized, and their insecticidal activities against armyworm (Leucania separata (Walker)) were tested. The conformation and structure of compound 1b was studied by 1 H NMR spectroscopy and X-ray crystallography. The crystal structure belongs to the orthorhombic system and the NN bond adopts a gauche conformation, which was assumed to be the active conformation, with a dihedral angle of 69.9°.Key words: N'-tert-butyl-N'-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazine, syntheses, insecticidal activity, conformation, crystal structure.
A Framework for Continuous Real-time Collaborative Editing (2011)

스마트폰의 보급과 소셜 네트워크 서비스의 활성화로 인해 문서 편집 분야에서도 여러 사용자가 하나의 문서를 동시에 편집하는 실시간 공동 편집에 대한 연구가 활발하게 진행되고 있다 실시간 공동 편집에서는 문서의 변경 사항에 대한 동기화를 위해서 참가자 간의 공동 편집 세션을 유지해야 한다. 공동 편집 중에 세션이 종료된다면 연결되어 있던 참가자들은 더 이상 공동 편집을 진행할 수 없게 된다 본 연구의 목적은 의도하지 않은 상황에서 편집 중인 세션이 종료되지 않는 지속적인 실시간 공동 편집을 위한 프레임워크를 개발하는 것이다. 본 논문에 제안된 공동 편집 프레임워크에서 공옹 편집 세션의 참가자는 언제든지 편집을 종료할 수 있고, 불안정한 네트워크로 인해 특정 참가자의 연결이 끊어지는 경우에도 공동 편집 세션은 지속적으로 유지될 수 있다. In the field of document editing, a real-time collaborative editing that multiple users edit a same document simultaneously has been actively studied. The co-editing session should be kept for the synchronization about the changes during the real-time collaborative editing of documents among the participants. If the session ends during collaborative editing, they wouldn't be able to continue co-editing anymore. The purpose of this study is to develop a framework for Continuous Real-time Collaborative Editing that disconnects the session in unintended situations. Participants should be able to terminate editing at any time in opened co-editing session, and certain participant is able to disconnected because of unstable networks. In this case, the editing session should be maintained without termination.
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea. (1990)

O6-Ethylguanine (O6-EtGua) is one of about a dozen different alkylation products formed in the DNA of cells exposed to the alkylating N-nitroso carcinogen N-ethyl-N-nitrosourea (EtNU). We have evaluated selectively the relative capacity of cells for the specific enzymatic repair of O6-EtGua as a determinant for the probability of malignant conversion. Eleven O6-EtGua-repair-proficient (R+) variant subclones were isolated from the O6-EtGua-repair-deficient (R-) clonal rat fibroblast line 208F by selection for resistance to 1,3-bis-(2-chloroethyl)-1-nitrosourea (frequency, approximately equal to 10(-5). Contrary to the 208F wild-type cells, all variants expressed O6-methylguanine-DNA methyltransferase activity, while both kinds of cells were deficient for repair of the DNA ethylation products O2- and O4-ethylthymine. After exposure to EtNU (less than or equal to 500 micrograms/ml; 20 min), cells were analyzed for the formation of piled-up foci in monolayer culture and of anchorage-independent colonies in semisolid agar medium. Depending on the EtNU concentration, the frequencies of piled-up foci and agar colonies, respectively, in the R+ variants were as low as 1/28th and 1/56th of those in the R- wild type. Contrasting with the cells from R+ variant-derived agar colonies, cells from 208F (R-) agar colonies gave rise to highly malignant tumors when implanted subcutaneously into syngeneic rats. No significant differences in the frequencies of piled-up foci were found between wild-type and variant cells after exposure to the major reactive metabolite of benzo[a]pyrene, (+)-7 beta, 8 alpha-dihydroxy-9,10 alpha-epoxy-7,8,9,10 alpha-tetrahydrobenzo[a] pyrene, for which stable binding to guanine O6 in cellular DNA has not been observed. The relative capacity of cells for repair of O6-alkylguanine is, therefore, a critical determinant for their risk of malignant conversion by N-nitroso carcinogens.
Stepped Spillway Hydraulic Model Investigation (1985)

A physical hydraulic model investigation was conducted to evaluate the performance of a stepped overflow spillway. The spillway has a standard ogee profile with continuous steps cut into the spillway face from just below the crest, to the toe. The steps significantly increase the rate of energy dissipation on the spillway face, thus eliminating or greatly reducing the need for a large energy dissipation basin at the spillway toe. Primary objectives of the investigation were to evaluate the effectiveness of the flow transition from the smooth crest profile to the steps, to quantify the energy dissipation on the spillway face, and to define the flow characteristics on the steps. The investigation demonstrated that this stepped spillway is quite effective at dissipating energy and that smooth flow transition from the spillway crest to the stepped face is easily achieved.