gebhart/patrepeval huggingface dataset:
Allelic methylation of H19 and IGF2 in the Beckwith — Wiedemann syndrome (1994)

Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth syndrome with associated embryonal tumours. Most BWS cases are sporadic but familial cases occur in 15% of patients and in these there is linkage to chromosome 11p15. In addition, a small number of patients have cytogenetic abnormalities involving chromosome 11p15. Approximately 20% of sporadic BWS patients have uniparental paternal disomy (UPD) of chromosome 11p15. This finding together with the observation that penetrance in familial cases depends on parental transmission, suggests that the gene(s) for BWS are imprinted. The recent demonstration of biallelic expression of the otherwise maternally imprinted IGF2 gene in some BWS patients implicates excess IGF2 expression in the disease. Here we have analysed the allele-specific methylation patterns in the IGF2 gene and in the neighbouring and reciprocally imprinted H19 gene in a group of 42 BWS patients, 10 of which were mosaic UPD cases. We found that allelic methylation of both genes was normal in all non-UPD cases, with the paternal allele being methylated, and was increased in UPD cases in proportion with the disomic lineage. These findings suggest that sporadic BWS is not associated with a general alteration of methylation imprinting of the IGF2 and H19 genes. The methylation assay used in this study thus also offers a simple and reliable diagnostic test of UPD for 11p15.5. An unexpected finding was a distortion of the frequency of AvaII alleles at the IGF2 locus exclusively in UPD BWS cases (P < 0.001). This further implicates the IGF2 gene in aspects of the BWS phenotype.
Die perioperative Intensivbetreuung von Frühgeborenen (2013)

Kernaussagen Operationen bei Frühgeborenen sind häufig, daher ist eine gute Kenntnis zur perioperativen Betreuung erforderlich. Die Physiologie des Früh- und Neugeborenen unterscheidet sich von der Physiologie aller anderen Lebensalter und weist eine hohe Variabilität auf. Diese muss jeder kennen, der Frühgeborene perioperativ betreut. Eine sichere perioperative Betreuung ist auch für kleine Frühgeborene aufgrund der zur Verfügung stehenden Anästhesieverfahren, kinderchirurgischer Technik und neonatologischer Intensivmedizin möglich. Kenntnisse von Komplikationen in der prä-, intra- und postoperativen Phase sowie während des Transportes zum OP müssen vorhanden sein. Die Führung und Einbeziehung der Eltern hat einen hohen Stellenwert für den Behandlungserfolg. Ein optimales Ergebnis lässt sich nur durch Zusammenarbeit von Kinderchirurgen, Anästhesisten, neonatologischen Intensivmedizinern und geburtshilflichem Team erzielen.
(VB-107)A REFERENCE GRID OF THE NORMAL HUMAN CORNEA VIEWED WITH A CONFOCAL MICROSCOPE (2000)

Perez-Gomez, Inma MSc; Hollingsworth, Jo BSc (Hons), MCOptom; Morgan, Philip PhD, MCOptom; Efron, Nathan PhD, DSc Author Information
A <i>cis</i> Element between the TATA Box and the Transcription Start Site of the Major Immediate-Early Promoter of Human Cytomegalovirus Determines Efficiency of Viral Replication (2007)

The promoter of the major immediate-early (MIE) genes of human cytomegalovirus (HCMV), also referred to as the CMV promoter, possesses a cis-acting element positioned downstream of the TATA box between positions -14 and -1 relative to the transcription start site (+1). We determined the role of the cis-acting element in viral replication by comparing recombinant viruses with the cis-acting element replaced with other sequences. Recombinant virus with the simian CMV counterpart replicated efficiently in human foreskin fibroblasts, as well as wild-type virus. In contrast, replacement with the murine CMV counterpart caused inefficient MIE gene transcription, RNA splicing, MIE and early viral gene expression, and viral DNA replication. To determine which nucleotides in the cis-acting element are required for efficient MIE gene transcription and splicing, we constructed mutations within the cis-acting element in the context of a recombinant virus. While mutations in the cis-acting element have only a minor effect on in vitro transcription, the effects on viral replication are major. The nucleotides at -10 and -9 in the cis-acting element relative to the transcription start site (+1) affect efficient MIE gene transcription and splicing at early times after infection. The cis-acting element also acts as a cis-repression sequence when the viral IE86 protein accumulates in the infected cell. We demonstrate that the cis-acting element has an essential role in viral replication.
Estimation of the Dynamic Matrix and Noise Model for Model Predictive Control Using Closed-Loop Data (2002)

A dynamic matrix is a lower triangular matrix containing the step response coefficients of the deterministic input used in the model predictive control schemes such as the dynamic matrix controller. Subspace matrices (defined in subspace state-space identification methods) corresponding to the deterministic input and the stochastic input contain the impulse response coefficients of the deterministic and stochastic models, respectively. This paper proposes a new subspace identification based method for the estimation of the dynamic matrix of the deterministic input(s) directly from the closed-loop data. The noise model is simultaneously obtained from the closed-loop data in the impulse response form. The method is extendable to the case of measured disturbances. All of the results presented in this paper are applicable to the multivariate systems. Guidelines for the practical implementation of the algorithm are also presented in this paper. The proposed method is illustrated through MATLAB simulations and an application on a pilot-scale plant.
Metabolomic Footprints of Lethal Versus Indolent Prostate Cancer (2014)

Abstract : The current study is to use a targeted, LC-MS-based metabololite profiling platform to measure and compare metabolic profiles of prediagnostic blood samples collected from men subsequently diagnosed with prostate cancer (PCa) and sample of men who remained cancer-free in a prospective cohort of the Physicians' Health Study (PHS). And test whether the metabolomics profiling are related to 1) metastatic PCa at diagnosis as compared with normal controls; and 2) among PCa patients, related developing fatal outcome as compared with long-term survivors. We will also assess whether these associations are independent of the known metabolic risk factors (overweight/obese, insulin marker C-peptide, insulin-like growth factor I (IGF-I), IGF binding protein 3, (IGFBP-3), and adiponectin) as well as the clinical characteristics defined as the D'Amico risk. In the original protocol, we plan to measure samples of PCa cases from both HPFS and PHS. During the first year, we were working on informative case and control selection and during this period of time, the HPFS team has received separate grant for metabolomics measurement. We, therefore, amended our study population to focus only on the PHS samples but stick to our original planned 400 study participants. Based on the available samples, we utilized matched case control design to select the blood samples to be measured. The selected blood samples are currently being pooled in the blood lab and due to a big queue of work load at the blood lab, we are waiting for blood sample aliquating and boxing.
Protease‐activated receptor‐4: a novel mechanism of inflammatory pain modulation (2006)

Taken together, these results identified PAR(4) as a novel potential endogenous analgesic factor, which can modulate nociceptive responses in normal and inflammatory conditions.
Degradation of ribonucleic acid by immobilized ribonuclease (1979)

Abstract An immobilized enzyme (pancreatic ribonuclease bound to porous titania) was investigated for the degradation of purified yeast ribonucleic acid as a substrate. The immobilized enzyme is active and stable in the pH range 4–8. Dependence of enzymatic activity on ionic strength, pH, temperature, fluid flow rate, and substrate concentration were investigated. A cummulative fluid residence time of 6 sec is sufficient for 5% substrate conversion at 25°C and pH 7.0. The critical flow rate (i.e., the fluid flow rate necessary to remove film diffusion resistance) approximately doubles with each 10°C rise in reaction temperature. The critical flow rates obtained in this study are about 40 times greater than those obtained for a similar study on immobilized glucose oxidase. Arrhenius plots gave activation energies of −9.6 and −7.1 kcal/g mol at pH 4.6 and 7.0, respectively. The work reported herein is a bench‐scale investigation of an immobilized enzyme with primary emphasis on the mass transfer and kinetic characteristics of the system. The rapid reaction rates obtainable at relatively low temperatures offfer a potential alternative method of purifying yeast single cell protein (SCP) with minimum loss of desired protein. The key questions are how such a system would react in a yeast homogenate, what conditions in such a system must be controlled, and what type of immobilized reactor should be utilized, if such further work continued to show promise.
Differential Diagnosis of Breast Mass and Staging of Breast Cancer Using F-18-FDG PET (1999)

Purpose: F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been proven to be useful in the differential diagnosis of breast mass and staging of breast cancer. This study assessed the diagnostic accuracy of F-18-FDG PET in the differentiation of breast mass and staging of breast cancer. Materials and Methods: Total 42 patients who had breast mass underwent F-18-FDG PET (all female, 40: 10 year old). We compared F-18 FDG PET results with pathologic findings in 24 patients Results: In the differentiation of breast mass, sensitivity and specificity were 95% (19/20) and 77% (7/9) respectively. Three false positive cases were due to inflammation and one false negative patient had small tumor less than 1 cm. In the assessment of axillary lymph node status, sensitivity and specificity were 73% (8/11) and 100% (7/7) respectively. We found distant metastasis that were not suspected before F-18-FDG PET in 2 patients. Conclusion: F-18-FDG PET shows good diagnostic performance in differentiation of breast mass and staging of breast cancer.
Muscle and femoral vein temperatures during short-term maximal exercise in heart failure (1985)

Core temperature decreases throughout short-term maximal exercise in heart-failure patients. To investigate possible causes for this unusual response to exercise, we studied core (pulmonary arterial blood), femoral vein, muscle, and skin temperatures in eight patients with severe heart failure who performed maximal upright incremental bicycle exercise to 50 W. A normal group (n = 4) was exercised for comparison. In the heart-failure patients, core temperature was 36.95 +/- 0.37 degrees C at rest, significantly (P less than 0.05) decreased at 25 W of exercise to 36.59 +/- 0.40 degrees C, and at 50 W remained decreased to 36.57 +/- 0.40 degrees C. In comparison, we found that the resting core temperature in the normal subjects was 37.28 +/- 0.34 degrees C, was the same at 25 W (37.29 +/- 0.41 degrees C), and increased significantly (P less than 0.05) to 37.50 +/- 0.32 degrees C at 50 W of exercise. Femoral vein temperature in heart-failure patients (n = 6) was below core temperature throughout exercise to 25 and 50 W (36.22 +/- 0.62 and 36.34 +/- 0.65 degrees C, respectively). Muscle temperature (n = 7) was significantly (P less than 0.05) lower in the heart-failure patients (34.8 +/- 1.1 degrees C) at rest compared with the normal subjects (36.2 +/- 1.0 degrees C). During exercise, muscle temperature increased above core temperature in only four of the heart-failure patients and was significantly (P less than 0.05) lower (36.5 +/- 1.3 degrees C) compared with the normal subjects (38.0 +/- 0.2 degrees C).(ABSTRACT TRUNCATED AT 250 WORDS)
ChemInform Abstract: AMINOSAEUREDERIVATE VON BENZO‐1,5‐DIAZEPIN (1972)

Abstract Das Benzylbromid (I) reagiert mit den Aminosäureestern (II) unterder Einwirkung von Säureakzeptoren zu den Benzylarninosäureestern (III), die teils bei der sauren und teils bei der alkalischen Hydrolyse in die Säuren (IV) übergehen.
Activity of omeprazole on Helicobacter pylori and relation to toxicity of strains. (1994)

H pylori cytotoxin is not the target of the antimicrobial activity of omeprazole. Should the drug reach clinically effective concentrations in vivo, it could potentially prevent the mucosal damage caused by the vacuolising activity of urease.
EVIDENCE FOR ALKYLIDENE INTERMEDIATES IN FISCHER-TROPSCH SYNTHESIS OVER Ru (1979)

Recent studies have shewn that caibenes can be LBL-8716 eliminated frem transition metal cemplexes by reactien with an elefin.This appreach.wasused to' search fer the presence ef alkylidenes, anticipated as intermediates in Fischer-Trepsch synthesis ever a Ru catalyst.Additien of ethylene to' the synthesis gas enhanced the fermatien ef prepylene, and the additien ef cyclehexene led to' the fermatien ef methyl-and ethylcyclehexene and ethyl-, propyl-, and butylcyclehexane.These ebservatiens suppert the hypethesis ef alkylidene intermediates.
Self-localization of Autonomous Mobile Robots using Information Buried in Environment. (1998)

Generally, in the self-localization method based on positions of landmarks, it is necessary for robots to manage the maps of the landmarks. In multiple robot systems, it is, however, difficult to keep the consistency among all the maps carried by the robots when the maps are updated frequently and dynamically. In this paper, we introduce Intelligent Data Carriers (IDCs) to realize map-free self-localization in multiple robot systems. The IDC is a portable data management device developed at RIKEN. By putting an IDC in the work area and storing its own position data in itself, robots can acquire the position of the IDC using local communication without refering to any maps. Detalied procedures to acquire and integrate various information are presented. The efficiency of the proposed method are discussed based on the results of the experiments. It is confirmed that this method is available for the robot to localize its own position in multiple robot environment.
Efficient model predictive control with prediction dynamics (2003)

An efficient robust model predictive control (MPC) strategy using augmented ellipsoidal invariant sets is enhanced by introducing more general dynamics in the future control moves (referred to as prediction dynamics) than simple time recession. This allows significant enlargements of the region of attraction for a give control horizon. As control horizons down to a single time step can be used, this implies online efficiency gains without decreasing performance. The procedure renders the offline problem a bilinear matrix inequality (BMI), thus algorithms for solving the non-convex offline problem is discussed.
Analysis of the influence of the passive facet of blazed transmission gratings in the intermediate diffraction regime (2008)

Blazed diffraction gratings are of enormous practical importance for imaging and analyzing hybrid optical systems. The intermediate diffraction regime is characterized by the transition from the scalar to the rigorous electromagnetic theory. An effect known as shadowing occurs and reduces the diffraction efficiency. Based on rigorous calculations for optimized sawtooth-shaped and binary-multilevel blaze profiles, we deduce a semianalytical model describing the shadowing phenomenon for the general case of oblique incidence. We discuss illumination both from air and from the substrate. Though a multilevel blaze possesses a discrete substructure, our shadowing model remains valid, if substructural effects are neglected. We find that electromagnetic effects due to the passive blaze facet lead to the efficiency reduction, and the blazing efficiency shows a linear dependence on the ratio of blaze wavelength to grating period. Our shadowing model is applied to predict the performance of a Littrow-like blazing condition in transmission geometry as, e.g., for a diffractive solid immersion lens.
New filovirus disease classification and nomenclature (2020)

Filoviruses, the members of the family Filoviridae, are currently classified into one proposed and five established genera (Supplementary Table 1). Of the twelve described filoviruses, six have been identified as aetiological agents of naturally occurring human disease outbreaks.
In Vitro Activity of Sodium Bisulfite and Heparin against Staphylococci: New Strategies in the Treatment of Catheter-Related Infection (1993)

Device-related infections often persist until the device is removed because systemic antibiotic therapy fails frequently. In an in vitro model, the activity of sodium bisulfite (an antioxidant added to many drugs) heparin with chlorbutol or chlorcresol as preservatives, and their combination with cefpirom for treating the internal surface of polyurethane and silicone catheters colonized with Staphylococcus aureus and Staphylococcus epidermidis was studied. Sodium bisulfite (0.05%) markedly reduced catheter colonization. Heparin combined with chlorbutol, 1000 micrograms/mL of cefpirom, and 0.05% of sodium bisulfite was not more effective than sodium bisulfite alone. A lesser effect was shown by treating adherent bacteria on both catheters with heparin plus preservatives alone. Not only antibiotics but also other substances with antibacterial activity should be evaluated for treatment and prophylaxis of catheter-related infection.
Cover Picture: Nanoscale Deposition of Single‐Molecule Magnets onto SiO<sub>2</sub> Patterns (Adv. Mater. 2/2007) (2007)

Abstract The cover shows a schematic of scanning probe nanolithography based on the spatial confinement of an oxidation reaction within a water meniscus, and its application for fabricating ordered arrays of cationic Mn12 single‐molecule magnets. Romero, Coronado, Garcìa, and co‐workers report on p. 291 that electrostatic interactions between the molecules and trapped charges within the nanodots drive the positioning of the molecules at the nanoscale.
Virtual Reality Based 3d Guidewire Propagation Simulation for Endovascular Intervention. (2009)

International audience
Some Items of Interest to Process R&D Chemists and Engineers as Selected by Trevor Laird and Stephen A. Hermitage (2000)

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTSome Items of Interest to Process R&D Chemists and Engineers as Selected by Trevor Laird and Stephen A. HermitageStephen A. HermitageView Author Information Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY UKCite this: Org. Proc. Res. Dev. 2000, 4, 6, 440–449Publication Date (Web):October 28, 2000Publication History Published online28 October 2000Published inissue 1 November 2000https://doi.org/10.1021/op0001032Copyright © 2000 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1180Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (162 KB) Get e-AlertsSUBJECTS:Anions,Catalysts,Reaction products,Solvents Get e-Alerts
Conducting polymers as electrochemical energy storage platforms (2014)

Solving the energy crisis and putting a halt to climate change is the greatest challenge of this century. In order to solve the energy crisis, harvesting energy from renewable sources needs to be economically and technologically feasible. Renewable energy sources are intermittent, but for our society to keep functioning uninterrupted access to electricity is a must. For this uninterrupted access, electrochemical energy storage (EES) is needed to provide energy when the renewable source is not available. Among EES, batteries and electrochemical capacitors (ECs) have shown the most promise, providing higher energy and power densities than other EES. In this publication conducting polymers as electrode materials are demonstrated to have improved performance over commercially available electrodes for EES applications. Conducting polymers are proven to be both electrocatalysts towards the redox reactions of organosulfur compounds and high gravimetric capacity electrode materials. Studies of the origin of the electrocatalytic effect yielded poly-3,4ethylenedioxythiophene (PEDOT) as the best electrocatalyst. The idea of incorporating small redox active substituents (RAS) is proven effective and the understanding of the electropolymeriation reaction of RAS-CP is achieved. A RAS-CP that had practical capacities of 80 mAh/g was designed; this capacity was higher than any other CP reported in the literature to date. Finally, the post-polymerization reaction was proven effective for the synthesis of RAS-CPs yielding polymers with enhanced capacity retention.
Diffusion Barrier Performance of thin Cr Films in theCu/Cr/Si Structure (1999)

We have studied the thermal stability of thin (from 10 to 40 nm) sputter deposited Cr layers as a diffusion barrier in Cu/Cr/Si structure. Sheet resistance measurements, DLTS, X-Ray Diffraction analysis (XRD), Rutherford Backscattering Spectroscopy (RBS), Auger Electron Spectroscopy (AES) and adhesion tests were carried out in order to reveal the behaviour of Cu and Cr in the Cu/Cr/Si structures. It is shown that even the 10 nm thin Cr layer preserves the multilayer structure up to 400°C, and Cu silicide formation is observed only after annealing at 450°C for 30 min. DLTS measurements revealed the Cu migration into the structure at lower temperatures (in this case at 350°C) than the other characterization techniques.
USR-VS: a web server for large-scale prospective virtual screening using ultrafast shape recognition techniques (2016)

Ligand-based Virtual Screening (VS) methods aim at identifying molecules with a similar activity profile across phenotypic and macromolecular targets to that of a query molecule used as search template. VS using 3D similarity methods have the advantage of biasing this search toward active molecules with innovative chemical scaffolds, which are highly sought after in drug design to provide novel leads with improved properties over the query molecule (e.g. patentable, of lower toxicity or increased potency). Ultrafast Shape Recognition (USR) has demonstrated excellent performance in the discovery of molecules with previously-unknown phenotypic or target activity, with retrospective studies suggesting that its pharmacophoric extension (USRCAT) should obtain even better hit rates once it is used prospectively. Here we present USR-VS (http://usr.marseille.inserm.fr/), the first web server using these two validated ligand-based 3D methods for large-scale prospective VS. In about 2 s, 93.9 million 3D conformers, expanded from 23.1 million purchasable molecules, are screened and the 100 most similar molecules among them in terms of 3D shape and pharmacophoric properties are shown. USR-VS functionality also provides interactive visualization of the similarity of the query molecule against the hit molecules as well as vendor information to purchase selected hits in order to be experimentally tested.
Myopic Keratomileusis With the Excimer Laser: One-Year Follow Up (1993)

Excimer laser myopic keratomileusis is an effective way to correct high myopia and may be more accurate than other methods of keratomileusis. A new nomogram for the procedure is presented.