gebhart/patrepeval huggingface dataset:
Lifetime Measurement of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mmultiscripts><mml:mi>P</mml:mi><mml:mn>2</mml:mn><mml:none/><mml:mprescripts/><mml:none/><mml:mn>3</mml:mn></mml:mmultiscripts></mml:math>Metastable State of Strontium Atoms (2004)

We have measured the lifetime of the 5s5p 3P2 metastable state of strontium atoms by magneto-optically trapping the decayed atoms to the ground state, which allowed sensitive detection of the rare decay events. We found that the blackbody radiation-induced decay was the dominant decay channel for the state at T=300 K. The lifetime was determined to be 520(+310)(-140) s in the limit of zero temperature, arguably the longest lifetime ever determined in a laboratory environment.
Transmission of Liquid Crystals in the near Infrared (1983)

Abstract The dynamic scattering mode (DSM) in nematic liquid crystals of negative dielectric anisotropy has been the subject of extensive fundamental and applied research, but almost all of these experiments have been performed in the visible spectral domain. In this wavelength range, when an increasing voltage (dc or low frequency ac) exceeding a threshold below 10 V is applied to a nematic thin layer held between two transparent electrodes, the incident light is scattered due to electrohydrodynamic instabilities, and the cell transmission decreases rapidly towards a low value (a few percent); this latter then remains constant, even if the applied voltage is high (80 V, for example).
New understandings in the genetics of congenital heart disease (1996)

In spite of the amazing success during the past half century in diagnosis and treatment of congenital heart disease, very little is known of its cause. However, a genetic cause has been clearly established for many forms of cardiovascular disease, and new understandings in the molecular genetics of congenital heart disease provide further insight. Progress has been quite impressive for some cardiovascular abnormalities, whereas in other areas the findings are more preliminary. For example, the molecular genetic cause of supravalvular aortic stenosis and the heart disease associated with Marfan syndrome has been clearly established. Impressive progress has been made in conotruncal defects, Holt-Oram syndrome, Alagille syndrome, and total anomalous pulmonary venous connection. In other areas, such as patent ductus arteriosus and atrioventricular septal defect, the findings are more preliminary. Taken as a whole, the prospect of understanding the genetic basis of congenital heart disease has never been better. Understanding the cause of congenital heart disease will provide new insights into both normal cardiac development and the pathophysiologic basis of congenital heart defects.
The impact of timetable on student’s absences and performance (2021)

Student's academic performance is the point of interest for both the student and the academic institution in higher education. This performance can be affected by several factors and one of them is student absences. This is mainly due to the missed lectures and other class activities. Studies related to university timetabling investigate the different techniques and algorithms to design course timetables without analyzing the relationship between student attendance behavior and timetable design. This article first aimed at demonstrating the impact of absences and timetabling design on student's academic performance. Secondly, this study showed that the number of absences can be caused by three main timetable design factors: namely, (1) the number of courses per semester, (2) the average number of lectures per day and (3) the average number of free timeslots per day. This was demonstrated using Educational Data Mining on a large dataset collected from Prince Sultan University. The results showed a high prediction performance reaching 92% when predicting student's GPA based on absences and the factors related to timetabling design. High prediction performance reaching 87% was also obtained when predicting student absences based on the three timetable factors mentioned above. The results demonstrated the importance of designing course timetables in view of student absence behavior. Some suggestions were reported such as limiting the number of enrolled courses based on student's GPA, avoiding busy and almost free days and using automated timetabling to minimize the number of predicted absences. This in turn will help in generating balanced student timetables, and thus improving student academic performance.
Contribution of functional voltage‐gated Na<sup>+</sup> channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: II. Secretory membrane activity (2003)

The secretory membrane activities of two rat prostate cancer cell lines of markedly different metastatic potential, and corresponding electrophysiological characteristics, were studied in a comparative approach. In particular, voltage-gated Na(+) channels (VGSCs) were expressed in the strongly metastatic MAT-LyLu but not in the closely related, but weakly metastatic, AT-2 cells. Uptake and release of the non-cytotoxic marker horseradish peroxidase (HRP) were used as indices of general endocytotic and exocytotic membrane activity, respectively. The amount of tracer present in a given experimental condition was quantified by light microscopic digital imaging. The uptake of HRP was an active process, abolished completely by incubating the cells at low temperature (5 degrees C) and suppressed by disrupting the cytoskeleton. Interestingly, the extent of HRP uptake into the strongly metastatic MAT-LyLu cells was almost twice that into the weakly metastatic AT-2 cells. Vesicular uptake of HRP occurred in a fast followed by a slow phase; these appeared to correspond to cytoplasmic and perinuclear pools, respectively. Importantly, the overall quantitative difference in the uptake disappeared in the presence of 1 microM tetrodotoxin which significantly reduced the uptake of HRP into the MAT-LyLu cells. There was no effect on the AT-2 cells, consistent with functional VGSC expression occurring selectively in the former. A similar effect was observed in Na(+)-free medium. The uptake was partially dependent upon extracellular Ca(2+) but was not affected by raising the extracellular K(+) concentration. We suggest that functional VGSC expression could potentiate prostate cancer cells' metastatic ability by enhancing their secretory membrane activity.
Analysis of the human operator subsystems (1991)

Except in low-bandwidth systems, knowledge of the human operator transfer function is essential for high-performance telerobotic systems. This information has usually been derived from detailed analyses of tracking performance, in which the human operator is considered as a complete system rather than as a summation of a number of subsystems, each of which influences the operator's output. Studies of one of these subsystems, the limb mechanics system, demonstrate that large parameter variations can occur that can have a profound effect on the stability of force-reflecting telerobot systems. An objective of this research was to decompose the performance of the human operator system in order to establish how the dynamics of each of the elements influence the operator's responses.
<title>Automatic segmentation of low-visibility moving objects through energy analyis of the local 3D spectrum</title> (1999)

Automatic object segmentation in highly noisy image sequences, composed by a translating object over a background having a different motion, is achieved through joint motion-texture analysis. Local motion and/or texture is characterized by the energy of the local spatio-temporal spectrum, as different textures undergoing different translational motions display distinctive features in their 3D (x,y,t) spectra. Measurements of local spectrum energy are obtained using a bank of directional 3rd order Gaussian derivative filters in a multiresolution pyramid in space- time (10 directions, 3 resolution levels). These 30 energy measurements form a feature vector describing texture-motion for every pixel in the sequence. To improve discrimination capability and reduce computational cost, we automatically select those 4 features (channels) that best discriminate object from background, under the assumptions that the object is smaller than the background and has a different velocity or texture. In this way we reject features irrelevant or dominated by noise, that could yield wrong segmentation results. This method has been successfully applied to sequences with extremely low visibility and for objects that are even invisible for the eye in absence of motion.
Azadideoxyadenosine: Synthesis, Enzymology, and anti‐HIV Activity. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Effects of liver abscess presence on stress-related physiological parameters associated with well-being in beef feedlot cattle (2020)

Production diseases, such as liver abscesses, can affect cattle performance; however, the well-being implications are not well understood. The purpose of this study was to investigate the effect of liver abscess presence on stress-related parameters in beef breed feedlot cattle. A total of 363 Bos taurus crossbred beef feedlot steers (675 ± 2.3 kg) were assigned to 1 of 3 groups in accordance with the liver abscess score assigned after slaughter: no liver abscess presence (n = 316), mild liver abscess presence (n = 21), and severe liver abscess presence (n = 24). Hair cortisol concentrations were obtained from hair samples collected from each animal 2 d before slaughter. A maximum eye temperature using infrared thermography and a mobility score were assigned to each animal. Serum cortisol concentrations were collected via exsanguination blood for 115 of the 363 animals. Analyses of variance were used to determine differences in measured well-being variables between liver abscess score groups. All measured parameters, including infrared thermography (P = 0.55), hair cortisol (P = 0.96), and serum cortisol (P = 0.21), showed no effect of liver abscess scores. No statistical analysis was performed with mobility data because only scores of normal locomotion were assigned. Under the conditions of this experiment, liver abscesses did not affect measured stress-related outcomes. Further research is warranted to improve our understanding of the relationship between liver abscess presence and other stress-related parameters associated with well-being in cattle.
On the Evolutionary Origin of Cyclooxygenase (COX) Isozymes (2004)

In vertebrates, COX-1 and COX-2, two cyclooxygenase isozymes with different physiological functions and gene regulation, catalyze identical reactions in prostaglandin synthesis. It is still not understood why there are multiple forms of COX enzyme in the same cell type and when the evolutionary duplication of the COX gene occurred. Here we report the structure of two genes encoding for COX isozymes in the coral Gersemia fruticosa, the first non-vertebrate organism from which a cyclooxygenase was characterized. Both genes are about 20 kb in size and consist of nine exons. Intron/exon boundaries are well conserved between coral and mammalian COX genes. mRNAs of the previously reported G. fruticosa COX-A (GenBank trade mark accession number AY004222) and the novel COX-B share 94% sequence identity in the coding regions and less than 30% in the 5'- and 3'-untranslated region. Transcripts of both COX genes are detectable in coral cells, although the transcriptional level of COX-A is 2 orders of magnitude higher than COX-B. Expression of both coral genes in mammalian cells gave functional proteins with similar catalytic properties. By data base analyses we also detected and constructed different pairs of COX genes from the primitive chordates, Ciona savignyi and Ciona intestinalis. These two gene pairs encode proteins with 50% intra-species and only 70% cross-species sequence identity. Our results suggest that invertebrate COX gene pairs do not correspond to vertebrate COX-1 and COX-2 and are consistent with duplication of the COX gene having occurred independently in corals, ascidians, and vertebrates. It is evident that due to the importance and complexity of its regulatory role, COX has multiple isoforms in all organisms known to express it, and the genes encoding for the isozymes may to be regulated differently.
Construction of artificial promoters highly responsive to iron deficiency (2004)

Abstract Iron deficiency-responsive element 1 (IDE1) and IDE2 are cis-acting elements that are responsible for Fe-deficiency-inducible and root-specific expression of the barley (Hordeum vulgare L.) gene IDS2 (Fe-deficiency-specific clone no. 2). Using these cis-acting elements, we aimed to construct super-promoters that would induce prominent gene expression in the roots of Fe-deficient rice plants (Oryza sativa L.). Modules containing IDE1 and IDE2 of the IDS2 promoter were used as repeats or were linked to the Fe-deficiency-responsive promoter of barley IDS3, and were connected to known enhancer-like sequences. Five artificial promoters, as well as the native promoters of barley IDS2 or IDS3, were connected individually upstream of β-glucuronidase (GUS) and were introduced into rice. Transgenic rice plants were grown under control or Fe-deficient conditions, and GUS expression was analyzed. The artificial promoter that contained one module of IDE1 and IDE2 conferred strong Fe-deficiency-inducible GUS expression to the roots of rice plants. Each of the five artificial promoters induced a similar level of GUS expression in Fe-deficient roots, which did not exceed the GUS expression driven by the native IDS2 or IDS3 promoter. Artificial and native promoters induced GUS expression in response to Fe-deficiency in leaves, although the level of expression was lower than that in roots. Histochemical observations revealed that GUS expression driven by artificial and native promoters was spatially similar, and expression was dominant within vascular bundles and root exodermis. These findings suggest that there is coordinated expression of the genes that are involved in Fe-deficiency-induced Fe uptake in rice. Key Words: artificial promoters cis-acting elementsFe-deficiencyinducible gene expressionphytosiderophores Additional informationNotes on contributorsTakanori Kobayashi These two authors contributed equally to this work Yuko Nakayama These two authors contributed equally to this work Naoko K. Nishizawa These two authors contributed equally to this work
Some factors that influence prolonged interfacial continuity (1984)

Bringing a percutaneous implant through the integument with the intentions of leaving it as a functional device for prolonged periods of time has not yet become a reality. If we are ever to achieve prolonged uninfected implants, attention must be directed toward a variety of failure mechanisms. Some of these mechanisms have defied our scrutiny, and our awareness of others are poorly understood. Some of the causes for failure of a percutaneous implant are the forces, either extrinsic or intrinsic, that cause shearing and tearing at the skin-implant interface. Extrinsic forces are defined as those forces applied either to the skin or the implant by the external environment. Intrinsic forces are those that have to do directly or indirectly with the body's growth and cell maturation, such as the retraction of maturing scar tissue and the surface migration of squamous epithelium. An intact skin-implant interface is important to attain in order to close the portal which might allow microbial invasion. The integument must remain intact, since a suppurative wound makes the implant's removal mandatory.
Twin mode NV logic gates for high speed computing system on 16nm FINFET CMOS logic process (2017)

A twin-mode non-volatile logic gates allowing multiple logic functions to be obtained by controlling its non-volatile states is proposed for the first time. This floating metal gate based cell consisting of an inverter controlled by slot contact inputs is successfully demonstrated by standard FinFETs processes in a 16nm technology node. This new twin-mode gates can not only enable reconfiguration capability for logic systems at a gate level, but also prompt the realization of tunable ring oscillators, for multi-functional IOT applications.
Classification of transition temperature behavior in ferroelectric PbTiO3–Bi(Me′Me″)O3 solid solutions (2006)

The ferroelectric transition temperature (Tc) behavior of perovskite solid solutions based on PbTiO3–Bi(Me′Me″)O3 (Me′=Fe3+, Zn2+, Sc3+, In3+, Mg2+, Ni2+, etc., and Me″=Ti4+, Nb5+, W6+) was considered. Trends in the Tc compositional dependence near the PbTiO3 end member could be described with a geometrical polynomial expression. Three main cases were observed: Case 1, a continued increase in transition temperature above the end member PbTiO3 (495°C); case 2, an increase and then decrease of the transition temperature; and case 3, a continuous decrease in the transition temperature with Bi(Me′Me″)O3 additions. It was noted that for all case 2 examples the enhancement of ΔTc=Tc(max)−Tc(PT) increased as the distribution of B-site ionic radii increased. A correlation was therefore proposed between the maximum enhancement in transition temperature and the spread of tolerance factor (Δt) and∕or variance in B-site ionic radius (σ2). Finally, it was proposed that these observations are consistent with random-field effects created by local strain-field fluctuations within the perovskite lattice.
Photoredox-Mediated Routes to Radicals: The Value of Catalytic Radical Generation in Synthetic Methods Development (2017)

Photoredox catalysis has experienced a revitalized interest from the synthesis community during the past decade. For example, photoredox/Ni dual catalysis protocols have been developed to overcome several inherent limitations of palladium-catalyzed cross-couplings by invoking a single-electron transmetalation pathway. This Perspective highlights advances made by our laboratory since the inception of the photoredox/Ni cross-coupling of benzyltrifluoroborates with aryl bromides. In addition to broadening the scope of trifluoroborate coupling partners, research using readily oxidized hypervalent silicates as radical precursors that demonstrate functional group compatibility is highlighted. The pursuit of electrophilic coupling partners beyond (hetero)aryl bromides has also led to the incorporation of several new classes of C(sp<sup>2</sup>)-hybridized substrates into light-mediated cross-coupling. Advances to expand the radical toolbox by utilizing feedstock chemicals (e.g., aldehydes) to access radicals that were previously inaccessible from trifluoroborates and silicates are also emphasized. Additionally, several organic photocatalysts have been investigated as replacements for their expensive iridium- and ruthenium-based counterparts. Lastly, the net C-H functionalization of the radical partner in an effort to improve atom economy is presented. An underlying theme in all of these studies is the value of generating radicals in a catalytic manner, rather than stoichiometrically.
Improving two-thumb text entry on touchscreen devices (2013)

We study the design of split keyboards for fast text entry with two thumbs on mobile touchscreen devices. The layout of KALQ was determined through first studying how users should grip a device with two hands. We then assigned letters to keys computationally, using a model of two-thumb tapping. KALQ minimizes thumb travel distance and maximizes alternation between thumbs. An error correction algorithm was added to help address linguistic and motor errors. Users reached a rate of 37 words per minute (with a 5% error rate) after a training program.
Electromagnetic levitation control of a traveling steel belt. Experimental considerations on the effects of the location of sensors and actuators. (1991)

For a traveling steel belt (SUS430) which is supported in a contactless manner by attractive forces of electromagnetic actuators, an experimental study on the effects of the location of sensors and actuators and effects of spillover of higher vibration modes were performed. As a result, in spite of the positioning of the sensors and actuators, it is shown that suboptimal control taking spillover of residual vibration modes into account is useful, and the determination of sensor and actuator positioning was examined.
<i>ANTHOCYANINLESS2</i>, a Homeobox Gene Affecting Anthocyanin Distribution and Root Development in Arabidopsis (1999)

The ANTHOCYANINLESS2 (ANL2) gene was isolated from Arabidopsis by using the maize Enhancer-Inhibitor transposon tagging system. Sequencing of the ANL2 gene showed that it encodes a homeodomain protein belonging to the HD-GLABRA2 group. As we report here, this homeobox gene is involved in the accumulation of anthocyanin and in root development. Histological observations of the anl2 mutant revealed that the accumulation of anthocyanin was greatly suppressed in subepidermal cells but only slightly reduced in epidermal cells. Furthermore, the primary roots of the anl2 mutant showed an aberrant cellular organization. We discuss a possible role of ANL2 in the accumulation of anthocyanin and cellular organization of the primary root.
Endoglycosidase H susceptibility of secreted and intracellular forms of dopamine beta-hydroxylase. (1989)

In an attempt to characterize the differences between various forms of dopamine beta-hydroxylase (DBH) the endoglycosidase H (endo H) susceptibilities of the intracellular and secreted DBH were compared. Both soluble and membrane-bound forms of newly synthesized DBH in PC12 cells were found to be susceptible to endo H. Soluble DBH, apparent Mr of 73K, was converted to 67K Mr and membrane-bound DBH, apparent Mr of 77K and 73K, shifted to 69K and 67K. Upon stimulation with the potent secretagogue, BaCl2, over 65% of intracellular dopamine and norepinephrine were secreted together with the soluble proteins of the secretory granules. DBH, released upon this stimulated secretion, was relatively resistant to endo H compared to the intracellular forms.
Which Medical Journals Have the Greatest Impact? (1986)

High-impact medical journals are identified using data from the 1981 and 1982 Journal Citation Reports. The Journal Citation Reports are an annual supplement to the Science Citation Index. Journals publish different types of editorial matter, much of which does not report substantive research. A special algorithm is used to calculate the number of substantial or "meaty" items. In 1981 The Lancet and The New England Journal of Medicine ranked highest among 78 journals in citations received; 53,945 and 47,887, respectively. These journals also have the highest impact factor, the average number of citations received by items in a journal's 1980 and 1981 issues. The British Medical Journal was highest in 1981 immediacy index, the measure of how quickly a journal's 1981 items were cited in 1981.
Event-Based Electric Vehicle Mass and Grade Estimation (2014)

This work investigates an event-based electric vehicle mass and grade estimation using a Recursive Least Squares (RSL) with variable forgetting factors method. Given the vehicle speed and electric power consumption, we proposed a two-layer identification architecture in which the first layer provides acceleration and cruise motion periods, whereas the second layer is responsible for mass and grade parameter estimations. The forgetting factors are updated based on the vehicle acceleration values. The proposed method does not require torque measurements from the propulsion system. Therefore, it can be used for different type of vehicles. The preliminary comparative study suggests that the proposed method is efficient and can provide satisfactory results even in presence of noisy measurements.