gebhart/patrepeval huggingface dataset:
Survival results among patients with alpha-fetoprotein-positive, unresectable hepatocellular carcinoma: analysis of three sequential treatments of the RTOG and Johns Hopkins Oncology Center. (1998)

Patients with unresectable alpha-fetoprotein-positive hepatocellular carcinoma experienced improved survival and decreased toxicity when managed with post-induction cycles of intra-arterial cisplatin as compared with intravenous doxorubicin and 5-FU. Intravenous 131I-polyclonal antiferritin did not improve survival when added to either post-induction regimen but dramatically increased hematologic toxicities.
Staging the industrial past. Current experiential strategies between Amsterdam, Rotterdam and Copenhagen (2017)

L'articolo indaga l'attuale tendenza dilagante consistente nella rigenerazione di ex aree industriali dismesse secondo una ricercata "mixit" caratteriale fatta di cultura, temporaneit, effimero, flessibilit.La mappatura preliminare di fenomeni in atto nella trasformazione della citt in crisi, tra Amsterdam, Rotterdam e Copenaghen, fa emergere il ruolo della comunit locale nell'innescare un processo di valore nella vacanza istituzionale del planning che non pi in grado di promuoverlo e di gestirlo.Ne derivano luoghi di/in transizione che ospitano funzioni a prevalente carattere culturale, promosse da un nuovo tipo di attori "2.0" come start-up, industrie creative, giovani imprenditori e operatori culturali.L'area dismessa ex industriale mira a trasformarsi, quindi, in una centralit urbana attraverso azioni graduali auto-innescanti, pianificate nel rispetto di cronoprogrammi a medio lungo termine.Questa politica, sostenuta da strumenti urbanistici adeguati, contribuisce alla riattivazione del potenziale latente della risorsa spaziale dismessa, in attesa di progettualit strutturali traguardanti interventi di rigenerazione permanenti.
Neural network-based decision support for incomplete database systems (1991)

Article Neural network-based decision support for incomplete database systems: Knowledge acquisition and performance analysis Share on Authors: B. Jin Department of Electrical and Computer Engineering, The Pennsylvania State University, University Park, PA Department of Electrical and Computer Engineering, The Pennsylvania State University, University Park, PAView Profile , A. R. Hurson Department of Electrical and Computer Engineering, The Pennsylvania State University, University Park, PA Department of Electrical and Computer Engineering, The Pennsylvania State University, University Park, PAView Profile , L. L. Miller Department of Computer Science, Iowa State University, Ames, IA Department of Computer Science, Iowa State University, Ames, IAView Profile Authors Info & Claims ANNA '91: Proceedings of the conference on Analysis of neural network applicationsMay 1991 Pages 62–75https://doi.org/10.1145/106965.105258Online:29 May 1991Publication History 4citation833DownloadsMetricsTotal Citations4Total Downloads833Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Blood Volume Determination, A Nuclear Medicine Test in Evolution (2013)

The method for determining blood volume has evolved substantially since first attempts were made in the latter part of the nineteenth century with the exsanguination of animals. The now accepted methods are based on indicator dilution methodologies. First attempts utilized inert dyes such as Evans Blue and Cardiogreen. These were found to be impractical due, primarily, to their rapid clearance from the blood. For many years, the most accepted method for blood volume determination was the dual isotope technique. This procedure utilizes chromium 51 or 99mTc to label autologous red cells and radioiodine 125 or 131 to label human serum albumin (HSA). Plasma and red cell volumes are measured separately and the results "combined". The procedure requires on-site labeling of autologous red cells and HSA, and meticulous preparation of standards and doses. The complexity of this method leads to performance times of 6 to 8 hours. An FDA-approved single isotope method is now employed in over 60 major institutions. HSA is labeled with radioiodine 131 at an FDA radiopharmaceutical facility, and test doses and standards are provided to laboratories in kit form. The red cell volume is derived by a calculation utilizing the measured plasma volume and the value for the average whole-body hematocrit. All calculations are carried out by a dedicated microprocessor, and a final report is generated and printed. The results are compared with predicted normal values for male and female patients based on percentage deviation from normal weight. Preliminary results are available in 30 minutes and complete calculations in 90 minutes.
Gender recognition from speech. Part I: Coarse analysis (1991)

The purpose of this research was to investigate the potential effectiveness of digital speech processing and pattern recognition techniques for the automatic recognition of gender from speech segments. In this paper "coarse" acoustic coefficients (autocorrelation, linear prediction, cepstrum, and reflection) were used to form test and reference templates for vowels, voiced fricatives, and unvoiced fricatives. The effects of different distance measures, filter orders, recognition schemes, and vowels and fricatives were comparatively assessed to determine their effectiveness for the task of gender recognition from speech segments. The results showed that most of the acoustic parameters worked well for gender recognition. A within-gender and within-subject averaging technique was important for generating appropriate test and reference templates. The Euclidean distance measure appeared to be the most robust as well as the simplest of the distance measures. The results from this study implied that the gender information is time invariant, phoneme independent, and speaker independent for a given gender. One recognition scheme achieved 100% correct speaker gender classification for a database of 52 talkers (27 male and 25 female). In part II of this paper [D.G. Childers and K. Wu, J. Acoust. Soc. Am. 90, 1841-1856 (1991); hereafter referred to as paper II] the detailed features of ten vowels that appeared responsible for distinguishing a speaker's gender were examined statistically. Included in paper II is a replication of part of the classical study of Peterson and Barney [J. Acoust. Soc. Am. 24, 175-184 (1952)] of vowel characteristics.
Porcine neural progenitors require commitment to the oligodendrocyte lineage prior to transplantation in order to achieve significant remyelination of demyelinated lesions in the adult CNS (2000)

Glial cell transplantation is a potential therapy for human demyelinating disease, though obtaining large numbers of oligodendrocyte precursors from nonrodent species is currently problematic. Culturing of multipotent neural progenitors may provide a solution to this problem, because these cells can be expanded in vitro whilst retaining the ability to differentiate into both neurons and glial cells. In order to investigate the myelinating capability of multipotent neural progenitors, we isolated cells from the porcine subventricular zone, a region rich in neural progenitors, and transplanted them into areas of persistent demyelination in the spinal cord of immunosuppressed rats, created by the injection of ethidium bromide and subsequent exposure to 40 Gy X-irradiation. Porcine SVZ cells were transplanted either within 12 h of isolation or after 7 days in B104-conditioned medium. Freshly isolated cells did not mature into myelinating oligodendrocytes following transplantation and instead remained as clusters of undifferentiated progenitors. However, cells exposed to B104-conditioned medium prior to transplantation were able to effect complete remyelination of the demyelinated axons. This suggests that neural progenitors must be manipulated in vitro for commitment to the oligodendrocyte lineage prior to transplantation if significant remyelination is to be achieved.
Full-Color Tuning of Surface Plasmon Resonance by Compositional Variation of Au@Ag Core–Shell Nanocubes with Sulfides (2012)

In the present study, we demonstrate the precise tuning of surface plasmon resonance over the full visible range by compositional variation of the nanoparticles. The addition of sulfide ions into the Au@Ag core-shell nanocubes generates stable Au@Ag/Ag(2)S core-shell nanoparticles at room temperature, and the plasmon extinction maximum shifts to the longer wavelength covering the entire visible range of 500-750 nm. Based on the optical property, the Au@Ag core-shell nanocubes are employed as a colorimetric sensing framework for sulfide detection in water. The detection limit is measured to be 10 ppb by UV-vis spectroscopy and 200 ppb by naked eyes. Such nanoparticles would be useful for decoration and sensing purposes, due to their precise color tunability and high stability.
ERNIE: Enhanced Language Representation with Informative Entities (2019)

Neural language representation models such as BERT pre-trained on large-scale corpora can well capture rich semantic patterns from plain text, and be fine-tuned to consistently improve the performance of various NLP tasks. However, the existing pre-trained language models rarely consider incorporating knowledge graphs (KGs), which can provide rich structured knowledge facts for better language understanding. We argue that informative entities in KGs can enhance language representation with external knowledge. In this paper, we utilize both large-scale textual corpora and KGs to train an enhanced language representation model (ERNIE), which can take full advantage of lexical, syntactic, and knowledge information simultaneously. The experimental results have demonstrated that ERNIE achieves significant improvements on various knowledge-driven tasks, and meanwhile is comparable with the state-of-the-art model BERT on other common NLP tasks. The source code of this paper can be obtained from https://github.com/thunlp/ERNIE.
Trace eyeblink conditioning in rabbits demonstrates heterogeneity of learning ability both between and within age groups (1996)

Rabbits 2 to 41 months of age were conditioned in the 500 ms trace eyeblink paradigm to cross-sectionally define the age of onset and the severity of age-associated impairments in acquisition of this relatively difficult hippocampally dependent task. Using a strict behavioral criterion of 80% conditioned responses (CRs), age-associated learning impairments were significant by 24 months of age. Among rabbits that successfully reached this criterion, impairments in acquisition plateaued at 30 months of age. However, the proportion of severely impaired rabbits (that failed to reach the 80% criterion) continued to increase age dependently. Using an easier criterion of 8 out of 10 CRs, behavioral impairments were not detected until 30 months of age, and cases of severe impairment (failure to reach criterion) were rare. Additional controls demonstrated that the deficits observed were not attributable to nonassociative changes that might have artifactually skewed the data. Even severely impaired 36-month-old rabbits were able to reach a criterion of 80% CRs when switched from a trace to a delay conditioning task that is not hippocampally dependent. The results are discussed in terms of operationally defining and predicting behavioral effects of aging, hypothetical neural mechanisms, and efficient experimental design.
Portable magnetic field dosimeter with data acquisition capabilities (1982)

Design concepts, engineering specifications, and performance test results are presented for a compact magnetic field dosimeter that is suitable for monitoring personnel exposures to steady-state and time-varying magnetic fields. The battery-operated dosimeter contains thin-film Hall sensors that record the magnetic induction (B) along three orthogonal axes. The Hall generators are operated in a pulsed mode, and the time rate of change of the magnetic induction (dB/dt) is determined for values of B recorded during consecutive sampling intervals (typically 75 ms). The pulsed mode operation also serves to reduce battery consumption. The dosimeter contains a programmable microprocessor-based logic circuit and 4096 12-bit words of permanent and random-access memory. Stored parameters include: (1) average values of B and dB/dt during a preset time interval (typically 5 min); (2) peak values of B and dB/dt during the preset interval; and (3) the number of times that specified threshold levels for these parameters are exceeded. An audible alarm is activated when B or dB/dt exceeds a specified threshold level. Sensitivity factors and threshold levels can be loaded into the dosimeter from a bench-mounted programmable calculator, which is also used at the end of each workday to record and process data stored in the dosimeter’s random-access memory.
Cloning and Expression of the Heterodimeric Deoxyguanosine Kinase/Deoxyadenosine Kinase of Lactobacillus acidophilus R-26 (1995)

Two uniquely paired deoxynucleoside kinases, deoxycytidine kinase/deoxyadenosine kinase (dCK/dAK) and deoxyguanosine kinase/deoxyadenosine kinase (dGK/dAK) are required, together with thymidine kinase (TK), for deoxynucleotide synthesis in Lactobacillus acidophilus R-26. Using polymerase chain reaction-generated probes based on N-terminal amino acid sequences, we have cloned tandem genes for 25- and 26-kDa polypeptides, whose derived amino acid sequences and size correspond to wild-type Lactobacillus enzyme subunits. Expression in Escherichia coli uses a single endogenous promoter and yields active dGK/dAK (approximately 3% of extracted protein) closely resembling wild-type dGK/dAK in specificity, kinetics, heterotropic activation, and end product inhibition. Alignment of cloned genes reveals 65% identity in their DNA sequences and 61% identity in derived amino acid sequences. Comparison with herpes-viral TKs reveals three conserved regions: glycine- and arginine-rich ATP-binding motifs and a D/E-R-S/H motif at the putative TK deoxynucleoside site. Greater homology, however, is seen upon multiple alignment of dGK with mammalian deoxycytidine kinases, yielding the consensus sequence-D/E-R-S-I/V-Y-x-D-.dGK also shares a sequence (-Y-D-P-T-I/L-E-D-S/Y-Y-) required for GTP hydrolysis by p21ras.
An Equilibrium Theory for Exclusion Chromatography of Branched and Linear Polymer Chains (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Equilibrium Theory for Exclusion Chromatography of Branched and Linear Polymer ChainsEdward F. Casassa and Yukiko TagamiCite this: Macromolecules 1969, 2, 1, 14–26Publication Date (Print):January 1, 1969Publication History Published online1 May 2002Published inissue 1 January 1969https://pubs.acs.org/doi/10.1021/ma60007a003https://doi.org/10.1021/ma60007a003research-articleACS PublicationsRequest reuse permissionsArticle Views857Altmetric-Citations320LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dopamine transporter polymorphism associated with externalizing behavior problems in children (2002)

Early childhood externalizing behavior is a stable and heritable pattern of aggressive and delinquent behavior that often leads to the development of serious psychiatric disorders such as conduct disorder and attention deficit hyperactivity disorder. We examined the relationship between parent reported externalizing behavior (assessed at ages 4, 7, and 9 years) and the VNTR polymorphism of the 3' untranslated region of SLC6A3 (DAT1) in a community sample of 790 children ascertained as part of our longitudinal twin and adoption studies. We applied the sibling-based methodology developed by Fulker et al. [1999: Am J Hum Genet 64:259-267] for estimating allelic association with quantitative traits, while controlling for population stratification. An extension of these methods allowed for the inclusion of monozygotic twins, dizygotic twins, siblings, and singletons. We have demonstrated that the 9-repeat variant of the DAT1 is a significant risk allele for externalizing behavior at ages 4 (P=0.001) and 7 years (P=0.02). Although the effect size was negligible at age 9 (P=0.92), a formal test of the developmental decrease in effect across the three ages was non-significant (P=0.70).
Inhibited Angiogenesis in Aging: A Role for TIMP-2 (2003)

Factors responsible for age-associated impairment of angiogenesis are poorly understood. We observed that in aged mice, new fibrovascular tissue within subcutaneous polyvinyl alcohol sponges expressed more tissue inhibitor of metalloproteinases (TIMP)-2 than did corresponding tissue from young mice. In complementary studies in vitro, we utilized young and aged human microvascular endothelial cell lines (hmEC36 and hmEC90, respectively) and compared their morphogenetic capacity within three-dimensional collagen. HmEC90 exhibited poor formation of tubular, capillary-like structures in vitro, diminished expression of active matrix metalloproteinase (MMP)-2, and similar or lesser amounts of MT1-MMP relative to hmEC36. Correspondingly, the MMP inhibitor GM6001 decreased tubulogenesis by hmEC36 to levels observed for hmEC90. In vitro, hmEC90 expressed similar quantities of TIMP-1, but more TIMP-2 than did hmEC36. Accordingly, purified TIMP-2 inhibited tubulogenesis by hmEC36. Collectively, our studies indicate that elevated levels of TIMP-2 modulate decreased angiogenesis in aged tissues, most likely via TIMP-2-mediated inhibition of MMP-2 and MT1-MMP.
Silver Nanoparticles: Sensing and Imaging Applications (2010)

Silver nanoparticles possess many valuable optical properties that have opened the door to new approaches in sensing and imaging applications, offering a wide range of detection modes such as colorimetric, scattering, SERS, and MEF techniques, at extremely low detection limits. Moreover, nanoparticles have made possible the use of scattering imaging techniques and have brought valuable improvements to standard imaging techniques. Silver nanoparticles may be introduced explicitly as labels, or may already be required in the application design to perform other functionalities, such as drug delivery, and simply provide this extremely useful added benefit. Although LSPR sensing offers many promising features, detection thresholds must be improved for most practical applications. A great deal of current research effort is directed towards the optimization of nanoparticle tunable properties to improve their response in LSPR sensors. One of the most promising contributions of silver nanoparticles to sensing and imaging applications is SERS. In this highly active research field, hundreds of papers are published each year on both fundamental aspects and applications. SERS has risen to its potential in the ultrasensitive detection of a wide variety of compounds, ranging from chemical pollutants to biomolecules, with detection thresholds as low as a single molecule, and the added advantage to provide structural information on the target molecule. It is to be expected that future improvements in this technique will be directed towards the development of more robust and reproducible sensors with a maximum coverage of hot spots. Additionally to SERS sensors, encapsulated SERS tags have emerged as an alternative to traditional fluorescent labeling offering advantages such as improved stabilities and multiplexing capability. On the other hand, MEF has also shown a great potential to address the deficiencies of traditional fluorescent labeling. Summarizing, although further research is required, future perspectives of silver nanoparticles include applications in multiplexing assays, massively parallel bioassays for high throughput screening of drugs, diagnostic level sensing for clinical assays, the study of biological interactions at the molecular level and the measurement of intermolecular distances of tens of nm with plasmon rulers.
Target Alkylation of Single and Double Strand DNA by Peptide Nucleic Acids (2011)

Quinone methides (QMs) generated in vivo can alkylate DNA and function as anti-cancer drugs. Delivery of QMs to target DNA is necessary to reduce the side effects caused by indiscriminate reaction. Previous, DNA was conjugated with a QM and was successfully used to deliver this QM to complementary DNA sequences. Peptide nucleic acids (PNAs) conjugates of QM are now being developed for in vivo application since PNA binds to its complementary DNA or RNA and PNA resists degradation by nucleases and proteases. The PNA1-QMP1 conjugate is capable of alkylating more than 60% of a complementary ssDNA when added at nearly stoichiometric quantities. No alkylation was observed if non-complementary DNA was treated with the conjugate. PNA1-QMP1 can alkylate a non-complementary DNA only when both the PNA and DNA target bind to a template strand. When no target sequences were present in solution, QM can react with nucleophiles from PNA1 and generate PNA1-QM1 self adduct. ssDNA can be alkylated by PNA1-QM1 self adduct with a 40% yield. The self adduct can survive after an incubation for 7 days in aqueous solution and preserve half of its original ability to alkylate complementary DNA. The reversibility and stability of the self adduct suggest that it can be used in cells. ssRNA can also be recognized and modified by PNA conjugates with a similar yield as earlier demonstrated with ssDNA. A PNA1-QM1 self adduct may also function as a telomerase inhibitor by alkylating RNA within telomerase. Polypyrimidine PNAs were prepared to bind to the major groove of duplex DNA selectively and expand the potential targets from single to double strand DNA. A cytosine-rich PNA recognized dsDNA and delivered an electron-rich QMP2 to its target sequences. The polypurine strand within a target dsDNA was alkylated at 37°C with a yield of 26%. PAN-QMP2 also showed strong selectivity toward its fully matched dsDNA over one base mismatch in the triplex recognition site. Successful delivery of a QMP to target single and double strand DNA by PNAs confirms that the use of PNA in vivo to target pre-selected sequences is feasible.
Provocations with perfume in the eyes induce airway symptoms in patients with sensory hyperreactivity (1999)

Asthma-like and other symptoms, such as irritation of the eyes, may be induced by exposure of both the airways and the eyes in patients with sensory hyperreactivity. This points to the importance of studying the sensory nervous system, not only in the airways, but also in other organs.
T'ao Ya or Pottery Refinements, Being a Translation with Notes and an Introduction. By Geoffrey R. Sayer. pp. x + 163. 9¾ × 7¼ in. Routledge and Kegan Paul, London, 1959. (1960)

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