gebhart/patrepeval huggingface dataset:
Identification of a Subgroup Antigen on the Neisseria meningitidis Group C Capsular Polysaccharide (1974)

Journal Article Identification of a Subgroup Antigen on the Neisseria meningitidis Group C Capsular Polysaccharide Get access Michael A. Apicella Michael A. Apicella From the Unit of Infectious Diseases, Department of Medicine, State University of New York, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 129, Issue 2, February 1974, Pages 147–153, https://doi.org/10.1093/infdis/129.2.147 Published: 01 February 1974 Article history Received: 11 April 1973 Revision received: 07 August 1973 Published: 01 February 1974
Applications and status of the finite-element MICHELLE gun &#x00026; collector simulation code (2009)

The MICHELLE two-dimensional (2D) and three-dimensional (3D) steady-state and time-domain particle-in-cell (PIC) code has been employed successfully by industry, national laboratories, and academia and has been used to design and analyze a wide variety of devices, including multistage depressed collectors, gridded guns, multibeam guns, annular-beam guns, sheet-beam guns, beam-transport sections, and ion thrusters. Recent work has included time dependent application for rf guns and photoemission gun applications. Time domain effects in RF guns and collector modeling has shown to be an important effect to capture. Thermionic emission in IOT guns and guns operating in the transition from space charge limited to temperature limited regimes require special attention to accurately predict the gun performance. Modeling thermal beams through guns and into transport regions multiplies the run time by a factor of about the increase in the number of particles to support a thermal beam distribution. As a result, a parallel version of MICHELLE is being developed to hold run times down. In the typical vacuum tube, the beam entering a collector is often in one of two states; as a DC beam or as a spent beam resulting from an RF interaction. The DC beam entering the collector is easily treated by the steady-state algorithm. This regime of operation often gives the highest peak power loads, which is an important design constraint to manage in the development process. However, MICHELLE can apply its time-domain ES PIC model to the bunched beam as well. In this case, the spent beam from an interaction region (from an interaction code or a PIC code) is brought into the collector as a function of time. One RF period of the beam is required and it is repeated and injected into the collector domain until a time-dependent steady-state has been achieved. Examples of new capabilities and applications will be presented.
Solid pseudopapillary tumor as a possible cause of acute pancreatitis. (2004)

Solid pseudopapillary tumor is generally known as a slow-growing pancreatic neoplasm with few, if any, symptoms. However, solid pseudopapillary tumors should be kept in mind as a possible cause of acute pancreatitis, especially in cases of non-alcoholic young women having an acute pancreatitis attack.
Magnetically inert medical projection system with an image‐guiding optical fiber (2008)

Abstract— A visual system for stimulating specific human brain functions inside a clinical magnetoencephalography (MEG) measurement chamber was developed. This system is based on a three‐panel LCOS projection unit and uses a 4.5‐m‐long image‐guiding optical‐fiber bundle to transfer the image into the magnetically shielded MEG measurement chamber. In addition to a proper optical system design, special attention had to be paid to all materials used inside the magnetically shielded chamber. Here, no interfering fields due to electrics or ferromagnetic materials are allowed. The system concept, optical design, and the realized prototype are presented.
Subisthmic Aortic Stenosis and Occlusive Disease (1960)

Coarctation of the aorta is a remarkably constant congenital lesion involving the distal aortic arch or isthmus. Indeed extensive anatomic studies indicate that the lesion is located at this site in all but 2% of the cases.<sup>1</sup>With increasing experience and progressive improvements in the surgical management of isthmic coarctation greater interest has been aroused in the relatively rare and more challenging subisthmic form of aortic stenosis. Although the clinical picture in both of these forms of coarctation is often quite similar, the surgical approach required for each of them may be considerably different. For this reason and in order to provide proper planning of the technical procedure it is important to distinguish between them and to determine before operation the precise location and extent of the occlusive lesion by means of aortography. While routine aortography for all cases of coarctation is not necessary, it is obviously essential in
Renal protection and angiotensin converting enzyme inhibition in microalbuminuric type I and type II diabetic patients (1996)

ACE inhibitors are a promising class of antihypertensive agents in diabetic patients with microalbuminuria. These drugs should be considered as first line agents in such patients, even in the absence of systemic hypertension.
Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD (2013)

Chronic obstructive pulmonary disease (COPD) is characterized by abnormal repair in the lung resulting in airway obstruction associated with emphysema and peripheral airway fibrosis. Because the presence and degree of airways disease and emphysema varies between COPD patients, this may explain the heterogeneity in the response to treatment. It is currently unknown whether and to what extent inhaled steroids can affect the abnormal repair process in the airways and lung parenchyma in COPD. We investigated the effects of fluticasone on transforming growth factor (TGF)-β- and cigarette smoke-induced changes in mothers against decapentaplegic homolog (Smad) signaling and extracellular matrix (ECM) production in airway and parenchymal lung fibroblasts from patients with severe COPD. We showed that TGF-β-induced ECM production by pulmonary fibroblasts, but not activation of the Smad pathway, was sensitive to the effects of fluticasone. Fluticasone induced decorin production by airway fibroblasts and partly reversed the negative effects of TGF-β treatment. Fluticasone inhibited biglycan production in both airway and parenchymal fibroblasts and procollagen 1 production only in parenchymal fibroblasts, thereby restoring the basal difference in procollagen 1 production between airway and parenchymal fibroblasts. Our findings suggest that the effects of steroids on the airway compartment may be beneficial for patients with severe COPD, i.e., restoration of decorin loss around the airways, whereas the effects of steroids on the parenchyma may be detrimental, since the tissue repair response, i.e., biglycan and procollagen production, is inhibited. More research is needed to further disentangle these differential effects of steroid treatment on the different lung compartments and its impact on tissue repair and remodeling in COPD.
MIMO channel capacity for fixed wireless: measurements and models (2002)

Recent breakthroughs in the application of information theory have shown great capacity increase by deploying multiple transmitting and multiple receiving antennas as compared to conventional single antenna systems. This work presents an experimental verification of the theoretical capacity prediction and a summary of measurement results for 16 fixed wireless locations in suburban New Jersey.
A subband adaptive filter with the statistically optimum analysis filter bank (1998)

Conventional subband adaptive digital filters using filter banks have shown degradation in their performance because of the nonideal nature of analysis filters. For this problem, we propose two kinds of subband adaptive digital filters. The first one has the statistically optimum analysis filter bank which minimizes error signals. This first method, however, needs some statistics of the signals; therefore, we propose another type of subband adaptive digital filter which requires no a priori knowledge of the statistics regarding the signals. Computer simulations are also given in order to show the efficiency of the proposed subband adaptive digital filters.
Generalized Thermodynamic and Transport Properties Evaluation for Nonpolar Fluids (1990)

Generalized thermodynamic and transport properties evaluation for nonpolar fluids was developed based on a four-parameter equation of state. Thermodynamic properties of the fluids were derived from thermodynamic relations and the equation of state, while the transport properties were evaluated through the use of the best available correlations. A computer code was subsequently developed with P and T as input to predict fluid properties in the superheated state as well as the saturation state including the saturated liquid properties. Specific volume, specific enthalpy, specific heat, viscosity, thermal conductivity, and surface tension are among the properties predicted. Predictions were compared to experimental data for different nonpolar fluids such as R-12, nitrogen, carbon dioxide, etc., and showed good agreement.
Detection of incipient tumours by screening of circulating plasma DNA: hype or hope? (2019)

<b>Background:</b> The last half-decade has been marked by a rapid expansion of research efforts in the field of so-called liquid biopsies, thereby investigating the potential of blood-derived cell-free tumour DNA (ctDNA) markers for application in clinical oncological management. The analysis of cfDNA appears to be particularly attractive for therapy monitoring purposes, while in terms of early cancer diagnosis and screening the potentials are just starting to be explored. Challenges, both of biological and technical nature, need to be addressed. One such challenge is to overcome the low levels of ctDNA in the circulation, intrinsic to many early-stage cancers. <b>Methods:</b> Here, we give an overview of the features of ctDNA and the approaches that are currently being applied with the ultimate aim to detect tumours in a presymptomatic stage. <b>Conclusion:</b> Although many studies report encouraging results, further technical development and larger studies are warranted before application of ctDNA analysis may find its place in clinic.
Mobile camera positioning to optimize the observability of human activity recognition tasks (2005)

The performance of systems for human activity recognition depends heavily on the placement of cameras observing the scene. This work addresses the question of the optimal placement of cameras to maximize the performance of these types of recognition tasks. Specifically, our goal is to optimize the quality of the joint observability of the tasks being performed by the subjects in an area. We develop a general analytical formulation of the observation problem, in terms of the statistics of the motion in the scene and the total resolution of the observed actions that is applicable to many observation tasks and multi-camera systems. A nonlinear optimization approach is used to find the internal and external (mounting position and orientation) camera parameters that optimize the recognition criteria. In these experiments, a single camera is repositioned using a mobile robot. Initial results for the problem of human activity recognition are presented.
An Impact Test Rig for Annular Plate Valve Models (1974)

The exploitation of computational techniques to predict the outcome of chemical reactions is becoming commonplace, enabling a reduction in the number of physical experiments required to optimize a reaction. Here, we adapt and combine models for polymerization kinetics and molar mass dispersity as a function of conversion for reversible addition fragmentation chain transfer (RAFT) solution polymerization, including the introduction of a novel expression accounting for termination. A flow reactor operating under isothermal conditions was used to experimentally validate the models for the RAFT polymerization of dimethyl acrylamide with an additional term to accommodate the effect of residence time distribution. Further validation is conducted in a batch reactor, where a previously recorded <i>in situ</i> temperature monitoring provides the ability to model the system under more representative batch conditions, accounting for slow heat transfer and the observed exotherm. The model also shows agreement with several literature examples of the RAFT polymerization of acrylamide and acrylate monomers in batch reactors. In principle, the model not only provides a tool for polymer chemists to estimate ideal conditions for a polymerization, but it can also automatically define the initial parameter space for exploration by computationally controlled reactor platforms provided a reliable estimation of rate constants is available. The model is compiled into an easily accessible application to enable simulation of RAFT polymerization of several monomers.
Making nursing models relevant for the practising nurse. (1991)

For thousands of years the goal of nursing has been to provide nurturing 'care' in a manner which assists individuals or groups of people to reach an optimal level of health. This defines the uniqueness of nursing, ie the care by the nurse versus the 'cure' of the physician. The motivation of providing nurturing care is the same today for the critical care nurse in a modern intensive care unit as it was for the parent in a cave.
High-Dose Therapy in Amyloidosis (2010)

High-dose melphalan with autologous stem cell support (SCT) has improved outcomes for patients with systemic AL amyloidosis. A significantly greater proportion of patients remain alive and progression-free 5 or 10 years post-therapy than with historical traditional regimens. However, at most only one-third of newly diagnosed AL patients are eligible for SCT and, as attempts to minimize morbidity and mortality lead to refined patient selection, fewer AL patients may ultimately have SCT made available to them. Standard oral melphalan and dexamethasone, as well as combinations that include the novel agents lenalidomide and bortezomib, may allow for rapid elimination of circulating light chains and achieve response rates similar to SCT. In addition, as more data are obtained about complete response frequency, response duration, and tolerability of the novel agents in AL patients, it is possible that the risk-to-benefit ratio of high-dose therapy as initial treatment will become less favorable and that SCT may become more appropriate as second-line therapy. Indeed, the central challenge of the upcoming decade will be how and when to best incorporate the novel agents, either alone or in combination with both conventional and high-dose chemotherapeutic regimens, into our armamentarium against AL. Certainly, more randomized clinical trials will be needed to answer these questions, requiring cooperative group involvement and cooperation among amyloidosis treatment centers. Fortunately, risk-adapted high-dose therapy and the novel agents have greatly expanded the options for AL patients compared with a decade ago and the future continues to look bright.
Inhibition of Neutrophil Cathepsin G by Oxidized Mucus Proteinase Inhibitor. Effect of Heparin (1999)

Oxidation of mucus proteinase inhibitor (MPI) transforms Met73, the P'1 residue of its active center into methionine sulfoxide and lowers its affinity for neutrophil elastase [Boudier, C., and Bieth, J. G. (1994) Biochem. J. 303, 61-68]. Here, we show that the oxidized inhibitor has also a decreased affinity for neutrophil cathepsin G and pancreatic chymotrypsin. The Ki of the oxidized MPI-cathepsin G complex (1.2 microM) is probably too high to be compatible with significant inhibition of cathepsin G in inflammatory lung secretions. Stopped-flow kinetics shows that, within the inhibitor concentration range used, the mechanism of inhibition of cathepsin G and chymotrypsin by oxidized MPI is consistent with a one-step reaction, [equation in text] whereas the inhibition of elastase takes place in two steps, [equation in text]. Heparin, which accelerates the inhibition of the three proteinases by native MPI, also favors their interaction with oxidized MPI. Flow calorimetry shows that heparin binds oxidized MPI with Kd, Delta H degrees, and Delta S degrees values close to those reported for native MPI. In the presence of heparin, oxidized MPI inhibits cathepsin G via a two-step reaction characterized by Ki = 0.22 microM, k2 = 0.1 s-1, k-2 = 0.023 s-1, and Ki = 42 nM. Under these conditions, in vivo inhibition of cathepsin G is again possible. Heparin also improves the inhibition of chymotrypsin and elastase by oxidized MPI by increasing their kass or k2/Ki and decreasing their Ki. Our data suggest that oxidation of MPI during chronic bronchitis may lead to cathepsin G-mediated lung tissue degradation and that heparin may be a useful adjuvant of MPI-based therapy of acute lung inflammation in cystic fibrosis.
Supplementary Data from Estrogen Receptor β-Mediated Inhibition of Actin-Based Cell Migration Suppresses Metastasis of Inflammatory Breast Cancer (2023)

<p>Supplementary figures 1-8. Supplementary Figure 1. ERβ expression is associated with clinical outcome in IBC patients. Supplementary Figure 2. Associations between ERβ expression and clinical outcome in patients with breast cancer. Supplementary Figure 3. Morphology of IBC cells with different ERβ levels. Supplementary Figure 4. Invasion and migration of IBC cells with different ERβ expression Supplementary Figure 5. ERβ affects metastasis of IBC tumors. Supplementary Figure 6. ERβ regulates genes that control actin cytoskeleton reorganization. Supplementary Figure 7. ERβ regulates genes that are involved in acting cytoskeleton remodeling. Supplementary Figure 8. RhoC and ERβ expression in IBC cells.</p>
SOMATOMEDIN ACTIVITY AND GROWTH HORMONE SECRETION (1980)

Anorexia nervosa in childhood and adolescence, associated with impaired growth can be considered as a form of chronic malnutrition. Twelve patients aged 11 to 17 years were investigated. In spite of increased GH secretion, plasma somatomedin activities were diminished in 8 cases. Plasma T4, T3 and arginine stimulated insulin secretion were also decreased. In six patients who gained weight a significant negative correlation was found between weight deficit and plasma somatomedin activity. Prolonged administration of growth hormone in one case did not stimulate the generation of somatomedin activity. Nutrition and increased insulin secretion could plan a role in changes observed during recovery.
AnEscherichia coli host strain useful for efficient overproduction of secreted recombinant protein (1998)

Periplasmic secretion of overexpressed Bacillus stearothermophilus alpha-amylase was analyzed in batch and fed-batch cultivations of Escherichia coli MG1655:pCSS4-p and the mutant strain CWML2:pCSS4-p. Under all conditions investigated, growth and product formation of MG1655:pCSS4-p were severely impaired by heterologous protein expression and/or processing, while E. coli CWML2:pCSS4-p was found to be more robust and to accumulate 2- to 3-fold higher maximum alpha-amylase levels. While this strain is itself potentially interesting for applications, its properties also illustrate the potential of the selection procedure that was employed to obtain it from its progenitor MG1655 (Weikert, C., Sauer, U., Bailey, J. E., 1997. Microbiol. 143: 1567-1574. Application of this procedure to existing industrial strains may lead to significantly improved process organisms.
Superelastic Pseudocapacitors from Freestanding MnO<sub>2</sub>-Decorated Graphene-Coated Carbon Nanotube Aerogels (2017)

In recent years, the demand for emerging electronic devices has driven efforts to develop electrochemical capacitors with high power and energy densities that can preserve capacitance under and after recovery from mechanical deformation. We have developed superelastic pseudocapacitors using ∼1.5 mm thick graphene-coated single-walled carbon nanotube (SWCNT) aerogels decorated with manganese oxide (MnO<sub>2</sub>) as freestanding electrodes that retain high volumetric capacitance and electrochemical stability before, under, and after recovery from 50% compression. Graphene-coated SWCNT aerogels are superelastic and fatigue-resistant with high specific surface area and electrical conductivity. Electrodeposition of MnO<sub>2</sub> onto these aerogels does not alter their superelasticity, with full shape recovery even after 10 000 compression-release cycles to 50% strain. Total (utilized) gravimetric capacitances of these aerogels before compression are similar to those under and after recovery from 50% compression over a wide range of scan rates with capacitances reaching 98 (468), 106 (522), and 128 F/g (626 F/g) at a scan rate of 2 mV/s, respectively. These gravimetric capacitances are preserved even after 10 000 compression-release cycles to 50% strain. Further, 50% compression of these aerogels increases the volumetric capacitance from 1.5 to 3.3 F/cm<sup>3</sup>. Before compression, the lifetime performances of these aerogels remain largely stable, with capacitance degrading by only ∼14% over the first 2000 charge-discharge cycles and remains constant for further 8000 cycles. Under 50% compression, capacitance displays a similar trend over 10 000 charge-discharge cycles. After recovery from 10 000 compression-release cycles to 50% strain, the aerogels show slightly greater capacitance loss of ∼28% over the first 2000 charge-discharge cycles and an additional ∼10% loss over the subsequent 8000 charge-discharge cycles. Finally, substantially higher gravimetric capacitance is achieved through greater MnO<sub>2</sub> deposition, facilitated by the large porosity of these aerogels, albeit at a loss of capacitance retention upon compression. These capacitors display the feasibility of coating graphene-coated SWCNT aerogels with various pseudocapacitive materials to create superelastic energy-storage devices.
A sparse data fast fourier transform (SDFFT) (2003)

A multilevel algorithm that efficiently Fourier transforms sparse spatial data to sparse spectral data with controllable error is presented. The algorithm termed "sparse data fast Fourier transform" (SDFFT) is particularly useful for signal processing applications where only part of the k-space is to be computed - regardless of whether it is a regular region like an angular section of the Ewald sphere or it consists of completely arbitrary points scattered in the k-space. In addition, like the various nonuniform fast Fourier transforms, the O(NlogN) algorithm can deal with a sparse, nonuniform spatial domain. In this paper, the parabolic reflector antenna problem is studied as an example to demonstrate its use in the computation of far-field patterns due to arbitrary aperture antennas and antenna arrays. The algorithm is also promising for various applications such as backprojection tomography, diffraction tomography, and synthetic aperture radar imaging.
ChemInform Abstract: SYNTHESES OF 3,4‐DIMETHYLPYRROLE (1976)

Abstract Die Umsetzung der Sulfinylamide (I) mit dem Butadien (II) führt zu den Cycloaddukten (III), aus denen durch Erhitzen in methanolischer, stark alkalischer Lösung die Titelverbindung (IV) erhalten wird.
Diffusion in high viscosity liquids (1973)

Abstract The diffusion coefficients D of n ‐hexane and of naphthalene in a series of hydrocarbon liquids with viscosities μ from 5 · 10 −4 to 5 kg m −1 sec −1 (0.5 to 5000 centipoise) have been measured at 25°C with a one Savart plate wavefront‐shearing interferometer. This apparatus allows direct determinations at effectively infinite dilution. The values obtained suggest that for a small solute diffusing in a large solvent a result consistent with earlier studies. The exponent of 2/3 may be rationalized on the basis of the Eyring rate theory.