gebhart/patrepeval huggingface dataset:
Molecular evidence for the lack of epidermal growth factor receptor gene expression in small cell lung carcinoma cells. (1987)

It has been shown that none of the small cell lung carcinoma (SCLC) cell lines possess epidermal growth factor (EGF) binding activity on their surface. We have examined several SCLC cell lines for the possibility that they may have EGF receptors but that the receptors are masked by an EGF-like protein factor(s), which may be produced by an autocrine mechanism. No evidence, however, was found for the production of such factors. We then used an EGF receptor complementary DNA to determine the state of the EGF receptor gene by Southern blot analysis. The receptor gene appears to be present in these cells in an intact, unrearranged form. These cells, however, were found to lack detectable levels of EGF receptor mRNA, suggesting a possible reason for the absence of EGF receptors on the cell surface. Furthermore, karyotype analysis revealed that SCLC cell lines Lu134 and H69 contained a morphologically normal chromosome 7, which carries the EGF receptor gene. Also, these SCLC cells contained the apparently normal chromosome 3 and exhibited the presence of c-raf-1 gene in an unrearranged form. Thus, the previously noted partial deletion of chromosome 3 is not necessarily common to the SCLC cells. Instead, the lack of EGF receptor is frequently found in SCLC cell lines and is distinct from the other types of lung cancer. We postulate that SCLC cells have some active regulatory mechanism which prevents the expression of EGF receptor gene.
A Pulse-radiolysis Study of the Reaction of Hydrated Electrons with N′-formylkynurenine and Related Compounds: Electron-transfer Reactions with Nucleic Acid Components (1977)

The reactivity of N'-formylkynurenine (FK) derivatives towards eaq has been investigated. The reduced transient species have been characterized (lambda max approximately 340, 440 nm, epsilon lambda max approximately 3000-1000 M-1 cm-1, pKa approximately 7.8). Owing to the strong FK electron affinity, electron-transfer reactions occur from purine (except guanine) and pyrimidine electron adducts to FK (k approximately 2-7 x 10(9) M-1 s-1). As some FK derivatives bind to DNA (or polynucleotides) the protective effect of complexation on FK-DNA (or polynucleotides) adduct formation has been investigated.
The Effect of Pupil Size on Visual Acuity in Uncorrected and Corrected Myopia (1979)

The effect of pupil size on the relation between Snellen visual acuity and corrected and uncorrected myopia was examined for 22 young subjects with degrees of myopia ranging from 0.75 D to 7.5 D. Effective pupil size was varied by inducing mydriasis and then placing artificial pupils of between 1.0 and 8.0 mm diameter before the eye. Both a constant chart luminance of 120 cd/m2 and a constant retinal illuminance of 2150 trolands were used. There was little difference in results for the two lighting conditions. For the corrected myopes considered as a group, maximum visual acuity occurred for 2--3 mm diameter pupils, but larger pupils reduced acuity only marginally. For the uncorrected myopes, variation in pupil size produced a large variation in visual acuity, and for refractive errors greater than about 1.5 D, the optimum pupil diameter was less than 1 mm. For uncorrected myopes of 3.0 D or less, visual acuity was nearly as good with a 1-mm pupil as for corrected myopes. The presented data are a useful guide to the clinician.
DLR measurements on the test experiment of T1.1 (1998)

PIV experiments at the EUROPIV nozzle with and without swirl have been performed by DLR Göttingen. A photographic PIV system utilising a rotating mirror for ambiguity removal has been used. The resulting images were evaluated with an optical/digital and with a fully digital PIV system developed at DLR. The usability of latex particles and olive oil droplets for seeding has been investigated during these experiments
Magnetic source localization and morphological changes in temporal lobe epilepsy: comparison of MEG/EEG, ECoG and volumetric MRI in presurgical evaluation of operated patients (1994)

Is MEG source analysis able to precisely locate the primary focal epileptic activity? 22 patients with pharmacoresistant temporal lobe epilepsy were recorded during presurgical evaluation simultaneously with multichannel MEG/EEG and invasive (subdural) electrodes to evaluate the increase of information gained by MEG concerning the localization of focal epileptic activity and lesions. With this systematic study it should become clearer how often MEG can establish a diagnostic bridge between function and morphology. In addition, MEG localization accuracy of focal epileptic activity was to be validated empirically by invasive EEG recordings and postsurgical outcome. Spikes in the MEG were used for magnetic source localization, and the result was combined with magnetic resonance imaging (MRI). All patients definitely suffered from temporal lobe epilepsy and revealed a structural abnormality in MRI. 17 patients with lesions in the temporal lobe were operated meanwhile and became markedly improved or seizure free. In 7 of 8 patients with a tumor and validated operation outcome, a very close correlation of the 3D-magnetic source localization and the border of the tumor in the brain was found (distance less than 10 mm). In 8 of 9 patients with a temporal/hippocampal atrophy and validated operation outcome, dipoles of epileptiform activity were located within the atrophic lobe.(ABSTRACT TRUNCATED AT 250 WORDS)
Automatic Road Sign Recognition Using Neural Networks (2006)

An automatic road sign recognition system first locates road signs within images captured by an imaging sensor on-board of a vehicle, and then identifies road signs assisting the driver of the vehicle to properly operate the vehicle. This paper presents an automatic road sign recognition system capable of analysing live images, detecting multiple road signs within images, and classifying the type of the detected road signs. The system consists of two modules: detection and classification. The detection module segments the input image in the hue-saturation-intensity colour space and locates road signs. The classification module determines the type of detected road signs using a series of one to one architectural Multi Layer Perceptron neural networks. The performances of the classifiers that are trained using Resillient Backpropagation and Scaled Conjugate Gradient algorithms are compared. The experimental results demonstrate that the system is capable of achieving an average recognition hit-rate of 96% using Scaled Conjugate Gradient trained classifiers.
Synthesis Lectures on Communication Networks (2006)

Synthesis Lectures on Communication Networks is an ongoing series of 50- to 100-page publications on topics on the design, implementation, and management of communication networks. Each lecture is a self-contained presentation of one topic by a leading expert.The topics range from algorithms to hardware implementations and cover a broad spectrum of issues from security to multiple-access protocols.The series addresses technologies from sensor networks to reconfigurable optical networks. The series is designed to: • Provide the best available presentations of important aspects of communication networks. • Help engineers and advanced students keep up with recent developments in a rapidly evolving technology. • Facilitate the development of courses in this field
Continuing Damage to Rat Retinal DNA During Darkness Following Light Exposure (2000)

The damaging effects of visible light on the mammalian retina can be detected as functional, morphological or biochemical changes in the photoreceptor cells. Although previous studies have implicated short-lived reactive oxygen species in these processes, the termination of light exposure does not prevent continuing damage. To investigate the degenerative processes persisting during darkness following light treatment, rats were exposed to 24 h of intense visible light and the accumulation of DNA damage to restriction fragments containing opsin, insulin 1 or interleukin-6 genes was measured as single-strand breaks (ssb) on alkaline agarose gels. With longer dark treatments all three DNA fragments showed increasing DNA damage. Treatment of rats with the synthetic antioxidant dimethylthiourea prior to light exposure reduced the initial development of alkali-sensitive strand breaks and allowed significant repair of all three DNA fragments. The time course of double-strand DNA breaks was also examined in specific genes and repetitive DNA. Nucleosomal DNA laddering was evident immediately following the 24 h light treatment and increased during the subsequent dark period. The increase in the intensity of the DNA ladder pattern suggests a continuation of enzymatically mediated apoptotic processes triggered during light exposure. The protective effects of antioxidant suggests that the light-induced DNA degradative process includes both early oxidative reactions and enzymatic processes that continue after cessation of light exposure.
Involvement of the Synaptic Adhesion-Like Molecule, SALM1, in learning and memory (2009)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
MEASUREMENT OF HIGHER-ORDER CORRELATION-FUNCTIONS BY INTENSITY CROSS-CORRELATION LIGHT-SCATTERING (1985)

We describe the principles and practice of the study of higher-order correlation functions in suspensions of colloidal particles by intensity cross-correlation light scattering.
Metabolism of Choline by Slices of Fatty Livers From Choline-Deficient Rats (1958)

Fatty livers were produced in rats by a choline-deficient diet and the metabolism of slices from the livers was studied. The addition of choline increased the qo 2 of slices of fatty liver more than it did the qo 2 of control slices. The qco 2 and R.Q. of both types of slices decreased in the presence of choline. For both the control and the fatty liver slices, an increased concentration of an unidentified material, (probably not betaine aldehyde), which reacted with 2,4-dinitrophenylhydrazine was found whenever the respiration medium contained choline. Fatty liver slices produced more of this substance relative to oxygen uptake.
Successful treatment of acute humoral rejection in a heart transplant patient. (1992)

Eight months after undergoing orthotopic heart transplantation, a patient had hypotension and biventricular heart failure. Endomyocardial biopsy specimens showed a modest cellular infiltrate, predominantly of plasma cells, and progressive myocyte injury, suggesting a humoral rejection process. The patient was treated with Minnesota antilymphoblast globulin and aggressively with plasmapheresis, resulting in evidence of myocyte repair, improved hemodynamics, and long-term survival.
Investigation of nonlinearity of a HTSC microstrip line at high power (2002)

We have investigated the nonlinearity of high temperature superconductive (HTSC) thin film planar circuits for high levels of applied power. A nonlinear modeling formulation based on the combination of the moment method (MoM) formulation and harmonic balance (HE) technique is applied for this purpose. A stripline filter is analyzed first to verify this nonlinear modeling. A HTSC microstrip line is then studied for the effects of HTSC material nonlinearity, such as the current density redistribution and the sharp-increase of conductor loss.
Initial NICER observations of a broadened iron line and QPOs in MAXI J1535a571. (2017)

Related 11884 INTEGRAL detects re- brightening of the black hole candidate MAXI J1535-571 11682 MAXI/GSC detection of an undergoing soft-to-hard state transition of MAXI J1535-571 11652 Re-brightening of the black hole candidate MAXI J1535-571 as it transitioned back to the soft state 11611 X-ray spectral hardening and radio non-detection of MAXI J1535-571 11568 Rapidly fading the black hole X-ray nova MAXI J1535-571 from MAXI/GSC observations 11020 MAXI J1535-571 currently shows softest spectrum 10899 Radio re-brightening of MAXI J1535-571 as it transitions back towards the hard state 10816 Brackett-Gamma emission
Ultracold Molecule Formation by Photoassociation (2009)

Bound Levels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
5.3 Further Connections and Directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2085.3.1 Ultracold Molecular Ions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 208
5.3.2 Tests of Fundamental Physical Constants and Symmetries . . . . . . . . 209
5.3.3 Quantum Computing with Ultracold Polar Molecules . . . . . . . . . . . . . 210
5.3.4 Ultracold Collisions and Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210
5.3.5 Final Speculations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211There are two basic approaches to forming ensembles of molecules with cold and
ultracold translational temperatures (below 1K and 1mK, respectively): (1) cooling
warmer molecules directly and (2) cooling ensembles of atoms to cold and ultracold
translational temperature, followed by association of these atoms intomoleculeswithout significant heating. The former approach includes many specific strategies, such
as helium buffer gas cooling (more generally “sympathetic cooling”) as described in
Chapter 13 by Campbell and Doyle, and electric dipole deceleration (more generally
magnetic dipole and polarizability deceleration) as described in Chapter 14 by van
de Meerakker, Bethlem, and Meijer. Other possible strategies are discussed there and
elsewhere [1,2].
A curved image-plate detector system for high-resolution synchrotron X-ray diffraction (2009)

The developed curved image plate (CIP) is a one-dimensional detector which simultaneously records high-resolution X-ray diffraction (XRD) patterns over a 38.7 degrees 2theta range. In addition, an on-site reader enables rapid extraction, transfer and storage of X-ray intensity information in </=30 s, and further qualifies this detector to study kinetic processes in materials science. The CIP detector can detect and store X-ray intensity information linearly proportional to the incident photon flux over a dynamical range of about five orders of magnitude. The linearity and uniformity of the CIP detector response is not compromised in the unsaturated regions of the image plate, regardless of saturation in another region. The speed of XRD data acquisition together with excellent resolution afforded by the CIP detector is unique and opens up wide possibilities in materials research accessible through X-ray diffraction. This article presents details of the basic features, operation and performance of the CIP detector along with some examples of applications, including high-temperature XRD.
Development of an Active Flap Rotor Model (2004)

ter (EC) and Eurocopter Deutschland (ECD) as industry partners within the Active Blade Concept (ABC). The content is to investigate in theory and experiment the possible benefits and the phenomena associated with an actively controlled flap located at the trailing edge of a helicopter rotor blade. The main focus is put on the reduction of vibration and noise radiation of the complete helicopter rotor and the expansion of the flight enve-lope by the use of multi-frequency higher harmonic flap control. The first phase of the research programme was dedicated to the numerical assessment of flap geometry, radial location, and optimal control inputs. The simula-tions showed best results for a 15 % chord flap, with different optimal radial locations, depending on the distur-bance considered. A more inboard flap location is most suitable for vibration reduction, while for noise reduc-tion the best results were obtained with a more outboard position. The design, manufacturing and experimental wind tunnel testing of a 4-bladed Mach-scaled rotor model in high speed and descent flight is realized during the second phase. 1.
Brownian Dynamics Simulations of Colloidal Suspensions Containing Polymers as Precursors of Composite Electrodes for Lithium Batteries (2012)

Dilute aqueous suspensions of silicon nanoparticles and sodium carboxymethylcellulose salt (CMC) are studied experimentally and numerically by brownian dynamics simulations. The study focuses on the adsorption of CMC on silicon and on the aggregation state as a function of the suspension composition. To perform simulations, a coarse-grained model has first been developed for the CMC molecules. Then, this model has been applied to study numerically the behavior of suspensions of silicon and CMC. Simulation parameters have been fixed on the basis of experimental characterizations. Results of brownian dynamics simulations performed with our model are found in qualitative good agreement with experiments and allow a good description of the main features of the experimental behavior.
General theory of the alkali metals present in the earth's upper atmosphere. II - Seasonal and meridional variations (1985)

International audience
Anionic Synthesis of Poly(9-methyl-9-trimethylsilyl-2-vinylfluorene) (PMSVF). Spontaneous Deprotection−Protonation of PMSVF with Potassium Methoxide/Methanol Gives Poly(9-methyl-2-vinylfluorene) (2003)

The BuLi or potassium naphthalide initiated polymerization is described of 9-methyl-9-trimethylsilyl-2-vinylfluorene (MSVF) in tetrahydofuran at −78 °C. The purification is described of this monomer and of 9,9-dimethyl-2-vinylfluorene (DMVF) by polystyrene (PS) beads that are functionalized with 9-alkylfluorenyllithium groups that act as both scavengers and indicators. In both Li and K ion mediated polymerizations of MSVF, narrow molecular weight distribution PMSVFs are obtained. For the Li ion mediated termination of the living polymer by methanol, the PMSVF is readily isolated. However, in the presence of potassium ion a spontaneous and catalytic deprotection occurs of the trimethylsilyl group by potassium methoxide (MeOK). This reaction appears to be prevented in the case of the Li ion by strong ion pair or ionic aggregate interactions of MeOLi.
The importance of early treatment of schizophrenia. (2007)

It is extremely important to treat schizophrenia as soon as possible after the onset. With delay in effective treatment, patients may be at increased risk for brain volume loss with adverse implications for long-term treatment outcomes. Providers should not try to "instruct" patients with schizophrenia, who often have impaired verbal learning abilities, about the necessity of adhering to their medication regimen, but instead should try to demonstrate that the treatment can effectively improve their lives. To this end, it is crucial to find a medication at a dose that relieves psychotic and affective psychopathology as quickly as possible. To optimize treatment adherence, it seems more practical for providers to help patients with schizophrenia feel subjectively better and recognize improvement than to impress them with the logic of the argument for taking medications. In treating schizophrenia, physicians also should be involved and accessible to patients and caregivers. Providers should treat their patients with respect, express their viewpoint succinctly and consistently, and make clear that the betterment of the patient is their goal.
A wavelet-based model compression method for three-dimensional electromagnetic data inversion (2013)

In this paper, we discuss an extension of our work (see Abubakar et al. (2012)) on the model compression scheme using a wavelet representation for improving the efficiency of the regularized Gauss-Newton inversion algorithm. The discretized unknown model parameter is represented by wavelet coefficients, and after applying a proper truncation criterion, the model may then be represented by a set of ‘reduced’ number of coefficients. The number of coefficients is usually much less than the number of the discretization using spatial voxels. For three-dimensional (3D) algorithms, we can reduce the computational complexity even more compared to 2D cases. For demonstration purposes, we show both synthetic and field data inversions. The numerical results show that we are able to significantly reduce the algorithm complexity both for computational time and memory usage.
ChemInform Abstract: PYRYLIUM SALTS. VI. DERIVATIVES OF 3,11‐DITHIATRICYCLO(5.3.1.12,6)DODECANE BY Y DIMERIZATION OF THIOPYRYLIUM‐3‐OLATES (1976)

Abstract Die Thiopyranone (III) [(IIIa) im 1:1‐Gemisch mit seinem As‐Isomeren] reagieren mit dem Perchlorat (II) in Acetonitril bzw. in Acetanhydrid/Essigsäure zu den Hydroxypyryliumperchloraten (I) (Betain‐Forrn) ‐ bzw. zu ihren Acetaten (IV); letztere lassen sich mit Trifluoressigsäure (5 Std., 20°C) zu den entsprechenden (I) desacetylieren.
In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor. (1991)

Treatment of T cells with staphylococcal enterotoxins in vitro is known to activate T cells in a subset restricted manner based on beta-chain variable region (V beta) gene expression. In particular, staphylococcal enterotoxin B (SEB) activates T cells bearing V beta 7 or V beta 8. We examined the ability of SEB to activate T cells in vivo. Treatment of C3H mice with doses of SEB ranging from 5 to 250 micrograms resulted in a dose-dependent activation of V beta 8+ T cells as reflected by increased interleukin 2 receptor (IL-2R) expression, proliferation to exogenous IL-2 and allogeneic cells, and production of gamma interferon. SEB also caused proliferation of the CD8+ subset of V beta 8+ cells in vivo. Thus, T-cell activation by SEB in vivo appears to be specific since V beta 2+ cells (non-SEB reactive) did not show increases in IL-2R expression similar to those seen with V beta 8+ cells nor did they proliferate. We then studied the ability of these activated cells to potentiate the immune response to a malignant progressor tumor. Treatment of C3H mice with 50 micrograms of SEB at the time of inoculation with tumor fragments resulted in a statistically significant decrease in the frequency of tumor outgrowth. These data demonstrate that treatment of C3H mice with SEB results in specific activation of V beta 8+ cells in vivo and that these activated cells are capable of preventing the outgrowth of a malignant tumor.
The use of manuka honey to promote wound healing (2013)

When wounds are not healing, or the healing is slow, this is usually because the wound is inflamed. Inflammation in a wound is also responsible for unsightly scars after a wound has eventually healed. The use of honey as a wound dressing prevents these problems through its potent antibacterial and anti-inflammatory activity. Another action of honey, its rapid debridement of wounds, also aids healing by removing bacteria-harbouring slough which gives rise to inflammation. With the use of Manuka honey, selected to have the right type and level of antibacterial activity, and with an appropriate dressing protocol that keeps honey present on the wound bed at all times, uncomplicated wounds will heal rapidly, painlessly, and without a visible scar. With complicated wounds, including ones failing to heal with any form of best-practice modern treatments, if Manuka honey is used appropriately it can be expected to have complete healing, with a cosmetically good outcome, within six to twelve weeks.