gebhart/patrepeval huggingface dataset:
Anti‐HTLV‐1 antibody positive cutaneous T‐cell lymphoma (1997)

BACKGROUND Adult T-cell leukemia/lymphoma (ATLL) is a neoplasm of the mature helper T-lymphocyte. Human T-lymphotropic virus type 1 (HTLV-1) has been shown to be the cause of this neoplasm. Recently, however, the HTLV-1 genome has been found in some patients with cutaneous T-cell lymphoma (CTCL), which suggests a causal relation of HTLV-1 to CTCL. Thus, the relation between the HTLV-1 genome and CTCL, as well as the difference between ATLL and CTCL, have come into question. METHODS The authors examined two patients with CTCL whose serum anti-HTLV-1 antibodies were constantly positive. The Southern blot technique, inverse polymerase chain reaction (IPCR), and polymerase chain reaction (PCR) with four sets of primers for gag, pol, env, and pX regions of HTLV-1 were used to clarify the distinctions between ATLL and CTCL. RESULTS Clinically, one patient presented with multiple subcutaneous nodules with involvements of the internal organ, and the other patient was typical for mycosis fungoides. No integration of HTLV-1 DNA was detected by IPCR or the Southern blot technique in either patient. PCRs with the four sets of primers were all found to be positive for HTLV-1 except one. CONCLUSIONS The authors conclude that ATLL should be differentiated from CTCL in view of the responsibility of HTLV-1 for promoting or maintaining CTCL. Cancer 1997; 79:269-74. © 1997 American Cancer Society.
The coding of vowel identity by patients who use the Ineraid cochlear implant (1992)

The aim of this experiment was to determine whether patients who use the Ineraid cochlear implant code formant frequency by means of the information in the time waveforms presented to the electrodes, or by the information in the distribution of energy among the electrodes. Six patients were presented three vowels for identification. The vowels presented in two configurations. In one, the temporal cues and distribution of energy cues were both appropriate for a given vowel. In the other, the temporal information specified one vowel while the distribution of energy specified another vowel. The results of the identification task indicated that patients relied on information contained in the distribution of energy for vowel identification. These results can be interpreted as indicating that the Ineraid overcomes the limited spatial resolution afforded by four monopolar electrodes by using the balance of energy among electrodes to produce a continuous, rather than discrete, coding of cochlear place of stimulation.
Sugars enhance the expression of gibberellin‐induced genes in developing petunia flowers (2000)

Sugar is essential for the development of detached Petunia hybrida flowers. We have shown that sucrose (Suc) and gibberellic acid (GA 3 ) are required for anthocyanin accumulation and the expression of various genes in developing petunia corollas. The effect of GA 3 on the expression of the gibberellin‐induced gene and chalcone synthase gene, in detached corollas, was promoted by metabolic sugars such as Suc, glucose (Glc) and fructose, but not by the nonmetabolized 3‐ O ‐methylglucose and the sugar alcohol, mannitol. Several pieces of evidence support sugars’ signaling role in the corollas and the possible involvement of hexokinase as the sugar sensor. Mannose, which is inefficiently metabolized but is phosphorylated by hexokinase at efficiency similar to Glc, was as effective as Glc in promoting gene expression and pigmentation. 2‐Deoxyglucose, which is a substrate for hexokinase but is not metabolized in glycolysis, also promoted gene expression. On the other hand, mannoheptulose, a competitive inhibitor of hexokinase, completely abolished the promotive effect of Glc. We suggest that sugar‐phosphorylation‐related signal transduction interacts with the gibberellin signal to induce gene expression and anthocyanin accumulation in developing petunia corollas.
A Self-Consistent Model for the Forward Price Dynamics (2003)

We consider mean-reverting stochastic processes and build a self- consistent model for forward price dynamics and their applications in power industries. This model with stochastic volatility of the forward price is built using the ideas and equations of stochastic differential geometry in order to close the system of equations for the forward price and its volatility. Stationary distributions for the forward price volatility are found analytically as well as the forward price curves in the one factor case. We consider two models for regular forward price volatility. 1)Pure exponential two parameter model with zero asymptotic. 2)Three parameter exponential model with non-zero asymptotic. The first model is a toy one although it can be used in the case of long terms, the second one is quite reliable for short terms. Those models will also play a role of initial conditions for a stochastic process described forward price volatility. We compare our results with those known from the literature.
Controlled Trial of a Multifaceted Intervention for Improving Quality of Care for Rural Patients With Type 2 Diabetes (2003)

A diabetes outreach service has the potential to improve the quality of diabetes care for rural patients. Future studies need to involve longer timelines and larger sample sizes.
Server Replication in Interactive, Push-Based Data Delivery Networks. (2004)

In a push-based system, updates that are made to objects are sent to clients, without them explicitly requesting these updates. The focus of this research is to develop a server replication protocol for such interactive, push-based networks. When a server gets overwhelmed and is serving more clients than it can handle, a replica is created. After the replication, a portion of the clients connected to the overwhelmed server are redirected to the new replica. The decisions (a) “at which particular server the replica is created” and (b) “which clients are redirected” can greatly influence the performance observed by the clients, the level of the service provided by the server, and the overall level of satisfaction with the functioning of the servers. In this paper, we identify a number of parameters that influence the selection of a new server and we develop an efficient and effective protocol, based on these parameters. The performance of the protocol is investigated through simulation. The protocol performs close to an ideal placement of objects and clients. On average a savings of 25% in was observed when compared with an uninformed strategy.
Optical arithmetic processing using improved redundant binary algorithms (1999)

Carry-free parallel arithmetic computing using redundant binary number representation is exploited. Based on the original two-step algorithm, several improved algorithms including modified two-step, one- step, canonical, and three-input algorithms are proposed to increase processing speed and simplify the implementation system. The symbolic substitution rules for redundant binary addition are represented by binary logic operations and realized using optical space-variant binary logic gates. The proposed optical architecture is suitable for realizing both binary logic and arithmetic operations.
Nonlinear propagation effects on broadband attenuation measurements and its implications for ultrasonic tissue characterization (1999)

International audience
Hepatic myelopathy as a presenting neurological complication in patients with cirrhosis and spontaneous splenorenal shunt (2008)

Hepatic myelopathy is a rare complication of chronic liver disease that is associated with extensive portosystemic shunts. The main clinical feature of hepatic myelopathy is progressive spastic paraparesis in the absence of sensory or sphincter impairment. Early and accurate diagnosis of hepatic myelopathy is important because patients with early stages of the disease can fully recover following liver transplantation. Motor-evoked potential studies may be suitable for the early diagnosis of hepatic myelopathy, even in patients with preclinical stages of the disease. Here we describe two patients who presented with spastic paraparesis associated with a spontaneous splenorenal shunt and without any previous episode of hepatic encephalopathy. One patient experienced improved neurologic symptoms after liver transplantation, whereas the other patient only received medical treatment, which did not prevent the progression of spastic paraparesis.
A framework for resource discovery in pervasive computing for mobile aware task execution (2004)

Aimed to provide computation ubiquitously, pervasive computing is perceived as a means to provide a user the transparency of anywhere, anyplace, anytime computing. Pervasive computing is characterized by execution of high-level user tasks in heterogeneous environments that use invisible and ubiquitously distributed computational devices. Resource discovery is an integral part of pervasive computing. Due to the limited computing capacities of the mobile entities in the pervasive space it becomes important for these entities to discover equivalent peers to execute complex tasks. Also requirements of tasks in pervasive space are diverse ranging from static resources like printers to dynamically varying resources like network bandwidth. This requires seamless aggregation of resources/services required for the execution of the task. This is further complicated by frequent associations and disassociation of mobile elements with hotspots which are highly variable in performance and availability. We believe that predicting variability of resources would make the task mobile aware rather than mobility oblivious. We propose a framework for estimation of future resource requirements, which would allow the mobile applications to adapt to wearing (due to disassociations and reassociations) of resources. We also show through case analysis that proactive systems benefit from our architecture.
Role of the β-Strand Insert in the Central Domain of the Fibrinogen γ-Module (2000)

The crystal structure of the fibrinogen γ-module (residues γ143−411) [Yee, V. C., et al. (1997) Structure 5, 125−138] revealed an unusual feature. Namely, residues γ381−390 in the functionally important COOH-terminal region form a β-strand that is inserted into an antiparallel β-sheet of the central domain (γ192−286), while the rest (γ393−411) seems to be flexible. To clarify the structural and functional importance of this β-strand insert, we analyzed the folding status of the plasmin-derived fibrinogen fragment D3 and several truncated variants of the γ-module expressed in Escherichia coli. It was found that D3, in which most of the COOH-terminal domain of the γ-module (γ287−379) is removed proteolytically, retains a γ374−405 peptide that seems to be associated noncovalently with the bulk of the molecule via its β-strand insert region. A study of the denaturation−renaturation process of D3 suggested that without this peptide its truncated γ-module remains folded but is destabilized. This was confirmed directly with the truncated recombinant variants of the γ-module, including residues γ148−392, γ148−373, and γ148−286. They all were folded, but those devoid of the β-strand insert were destabilized. The results indicate that although the β-strand insert contributes to the stabilization of the γ-module, it can be removed without destroying the compact structure of the latter. On the basis of this finding and some other observations, we propose a mechanism for the function-related conformational changes in the fibrin(ogen) γ-modules.
Semiconductor RAMs: Limits to growth (1977)

Semiconductor memories are the most competitive, high technology products in the semiconductor industry. Typically, each type of semiconductor RAM introduced to the market quadruples in the number of bits per chip every two to four years. This increase in bit capacity has been achieved simultaneously with an improvement in performance, as well as a steadily decreasing price per bit. The exponential rate of growth of semiconductor memories over the last eight years can be attributed to the advancement in the following three areas: (1) design innovations leading to simpler and smaller memory cells, improved sense amplifier techniques, and more effective overall circuit design; (2) tighter design rules and smaller element sizes due to improved process technology, and (3) larger chip sizes possible because of higher processing yields.
Inhibition of mitogen and immune blastogenesis by two distinct populations of suppressor cells present in the spleens of fibrosarcoma‐bearing mice: Adoptive transfer of suppression (1978)

Abstract Mitogen and immune blastogenic responses were progressively impaired in the spleens of mice with transplanted fibrosarcomas. Spleen cells from tumour‐bearing BALB/c mice were shown to suppress in vitro phytohemagglutinin (PHA) and immune blastogenesis of normal syngeneic spleen cells. Nylon wool column and other depletion techniques were utilized to characterize the cellular source of suppressive activity in tumour‐bearing host (TBH) spleens. Evidence is presented for two distinct suppressor cell systems operating in the spleens, but not lymph nodes, of TBH BALB/c mice. Both normal and TBH splenic macrophages were shown to suppress in vitro PHA and immune blastogenesis at high in vitro concentrations. No functional difference was detected between normal and TBH splenic macrophages. Suppressor T cells, detected in a macrophage‐depleted culture system, significantly suppressed normal spleen cell blastogenesis at low in vitro concentrations. Anti‐Thy 1 serum‐sensitive suppressor T cells elaborated an immunosuppressive material that could also mediate inhibition of blastogenesis. Tumour‐bearing host thymocytes also elaborated such a material. No soluble inhibitor(s) was released by macrophages or TBH lymph‐node cells. The suppressor T cell was tentatively defined as a spleen‐seeking, mildly nylon‐wool‐adherent, and anti‐Thy 1 serum and hydrocortisone succinate‐sensitive T lymphocyte. Adoptive transfer studies revealed that both macrophages (normal or TBH) and suppressor T cells were inhibitory. The data suggest that suppressor T cells may significantly affect blastogenesis at low in vitro and in vivo concentrations, whereas macrophage‐mediated suppression requires higher concentrations.
Field experiences with the measurement of partial discharges on rotating equipment (1999)

This paper describes some of the authors' practical experiences in the on-line measurement of partial discharges in medium voltage motor and generator stator windings. Economic considerations are discussed as well as the use of traditional and nontraditional sensor applications. Comparisons and practical recommendations are provided.
Solid-State NMR, Crystallographic and Density Functional Theory Investigation of Fe−CO and Fe−CO Analogue Metalloporphyrins and Metalloproteins (1999)

We have synthesized and characterized the following four metalloporphyrins: Fe(OEP)(CO)(1-MeIm), Ru(OEP)(CO)(1-MeIm), Os(OEP)(CO)(1-MeIm), and Fe(TPP)(iPrNC)(1-MeIm), where OEP = 2,3,7,8,12,13,17,18-octaethylporphyrinate, TPP = 5,10,15,20-tetraphenylporphyrinate, and 1-MeIm = 1-methylimidazole, using single-crystal X-ray diffraction, solid-state nuclear magnetic resonance (NMR), and density functional theory (DFT) methods. Unlike the situation found with the Fe-, Ru-, Os(TPP)(CO)(1-MeIm) analogues, which have ruffled porphyrins, all four systems here have essentially planar porphyrin rings, and a rule is developed that successfully predicts the presence or absence of ring distortion in a broad range of metalloporphyrins. In each of the three CO complexes, the M−C−O bond is close to linear and untilted, but with the iPrNC adduct, there are noticeable ligand distortions supporting the idea that RNC groups (but not CO) may be distorted in metalloproteins. Solid-state 13C, 15N, and 17O NMR shifts and shift tensors determined experimentally are in generally good agreement with those computed via DFT. For isocyanide binding to proteins, the experimental shifts are more deshielded than in the model system, and the effects which might contribute to this difference are explored theoretically. Unlike CO, electrostatic field effects are unlikely to make a major contribution to protein shielding. Neither are Fe−C−N tilt−bend distortions, although a bend at nitrogen is energetically feasible and also gives a large deshielding, as seen with proteins.
Effect of residue 65 substitutions on thermal stability of tissue plasminogen activator kringle-2 domain (1989)

We have used differential scanning calorimetry to measure the effect of replacements of valine 65 on thermal stability of the isolated kringle-2 domain of tissue plasminogen activator (t-PA). The role of this site in stability was examined because a human t-PA variant having this valine (residue 245 in t-PA numbering) replaced with a methionine has been described [Johnston, M.D., & Berger, H. (1987) U.K. Patent Application GB 2176702A]. Mutants of kringle-2 having valine 65 replaced with Met, Leu, Ile, Thr, Ala, or Ser were constructed by using site-directed mutagenesis in conjunction with a restricted site selection strategy. Isolated kringle-2 domains were expressed in Escherichia coli and purified as previously described for the wild-type domain [Cleary, S., Mulkerrin, M.G., & Kelley, R.F. (1989) Biochemistry 28, 1884-1891]. None of these substitutions results in a significant perturbation of the native conformation of kringle-2 as judged by far-UV circular dichroism and equilibrium dialysis measurements of L-lysine affinity. A two-state analysis of the heat capacity profile observed for heating a solution of wild-type (w-t) kringle-2 containing 100 mM citrate, pH 4.5, provides values of 64.3 +/- 0.8 degrees C for Tg (melting temperature), 81 +/- 5 kcal/mol for delta H g, and 1.2 +/- 0.9 kcal/(mol-deg) for delta C p. Thermal denaturation of w-t kringle-2 is reversible in the pH range 3-6 as indicated by the observation of similar heat capacity profiles for consecutive heating cycles and also recovery of spectroscopic and lysine binding properties upon cooling the heat-denatured protein.(ABSTRACT TRUNCATED AT 250 WORDS)
Measurement of infiltration rates in urban sewer systems by use of oxygen isotopes (2005)

The paper presents the principle of a method to measure infiltration rates in sewer systems based on the use of oxygen isotopes and its application in Lyon (France). In the urban area of Lyon, significant differences in delta 18O that can reach 3 per thousand are observed between the oxygen isotopic compositions of groundwater originating from Rhone, Saone and from their associated alluvial aquifers. Drinking water supplying Lyon results mainly from pumping in the Rhone alluvial aquifer. Therefore, in some areas, the difference of isotopic composition between wastewater resulting from the consumption of drinking water and local groundwater can be used to measure infiltration in sewer systems. The application in the catchment of Ecully shows that the infiltration flow rate presents strong fluctuations at an hourly scale: it varies between 15 and 40 m3/h. This variability could be explained by non-constant discharges of pumping and by variations of the water level in the sewer.
ChemInform Abstract: N,N‐((4‐NITRO‐1H‐INDEN‐1‐YLIDENE)METHYL)DIALKYLAMINES BY AN UNEXPECTED REACTION (1982)

Abstract 1‐(β‐Methoxyvinyl)‐2‐methyl‐3‐nitrobenzol (I) reagiert mit Dimethylformamidacetal (II) und Pyrrolidin (III) in DMF über diskutierte Zwischenstufen zu einem Nitroaminomethylen‐inden (IV).
Rifamycins.<sup>1</sup> XXXV.<sup>2</sup> Amides and Hydrazides of Rifamycin B<sup>3</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRifamycins.1 XXXV.2 Amides and Hydrazides of Rifamycin B3P. Sensi, N. Maggi, R. Ballotta, S. Fürész, R. Pallanza, and V. ArioliCite this: J. Med. Chem. 1964, 7, 5, 596–602Publication Date (Print):September 1, 1964Publication History Published online1 May 2002Published inissue 1 September 1964https://pubs.acs.org/doi/10.1021/jm00335a005https://doi.org/10.1021/jm00335a005research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SOME MOLECULAR COLLISION INTEGRALS FOR POINT ATTRACTION AND REPULSION POTENTIALS (1956)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Receptors for Maleylated Proteins Regulate Secretion of Neutral Proteases by Murine Macrophages (1982)

Receptors for maleylated or acetylated proteins as well as for alpha-2-macroglobulin-protease complexes on macrophages serve as scavengers by mediating the uptake of macromolecules from the extracellular compartment. Described in this report is a novel function of these receptors on macrophages: regulation of neutral protease secretion. The binding of maleylated bovine serum albumin to macrophages triggered secretion of three neutral proteases: neutral caseinases, plasminogen activator, and cytolytic proteinase. Release of acid phosphatase, however, was not induced. An important biological consequence of protease secretion by macrophages, tumor-cytolysis, was also triggered by engagement of the receptor for maleylated bovine serum albumin. By contrast, the binding of alpha-2-macroglobulin-protease complexes to the macrophages suppressed secretion of all three proteases. Thus two receptors heretofore believed to serve principally as scavengers also regulate secretory functions of macrophages.