gebhart/patrepeval huggingface dataset:
Identifying newborns at risk of significant hyperbilirubinaemia: a comparison of two recommended approaches (2005)

The pre-discharge bilirubin expressed as a risk zone on an hour specific bilirubin nomogram is more accurate and generates wider risk stratification than a clinical risk factor score.
Novel Fabry-Perot fiber optic sensor with multiple applications (2004)

A novel Intrinsic Fabry-Perot fiber-optic sensor is presented in this paper. The sensors were made through two simple steps: wet chemical etch and fusion splice. Micro air-gaps were generated inside the fibers and functioned as reflective mirrors. This procedure not only provides a simple and cost effective technology for fabricating intrinsic Fabry-Perot Interferometric (IFPI) fiber sensors, but also provides two possible IFPI structures. Both of the fiber cavity between the air-gaps or the air-gap and cleaved fiber end can be used as sensing elements. With these two structures, this sensor can be used to measure the temperature, strain, pressure, refractive index of chemicals and the thin film thickness by itself. Multi-point measurements can also be achieved by multiplexing. Furthermore, it also can be multiplexed with other sensors such as Long Period Gratings (LPG) to provide compensations for other perturbation sensing. Theoretical and experimental studies of two sensor structures are described. Experimental results show that high resolution and high sensitivity can be obtained with appropriate signal processing.
Gene expression profiles for the human pancreas and purified islets in Type 1 diabetes: new findings at clinical onset and in long-standing diabetes (2009)

Type 1 diabetes (T1D) is caused by the selective destruction of the insulin-producing beta cells of the pancreas by an autoimmune response. Due to ethical and practical difficulties, the features of the destructive process are known from a small number of observations, and transcriptomic data are remarkably missing. Here we report whole genome transcript analysis validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and correlated with immunohistological observations for four T1D pancreases (collected 5 days, 9 months, 8 and 10 years after diagnosis) and for purified islets from two of them. Collectively, the expression profile of immune response and inflammatory genes confirmed the current views on the immunopathogenesis of diabetes and showed similarities with other autoimmune diseases; for example, an interferon signature was detected. The data also supported the concept that the autoimmune process is maintained and balanced partially by regeneration and regulatory pathway activation, e.g. non-classical class I human leucocyte antigen and leucocyte immunoglobulin-like receptor, subfamily B1 (LILRB1). Changes in gene expression in islets were confined mainly to endocrine and neural genes, some of which are T1D autoantigens. By contrast, these islets showed only a few overexpressed immune system genes, among which bioinformatic analysis pointed to chemokine (C-C motif) receptor 5 (CCR5) and chemokine (CXC motif) receptor 4) (CXCR4) chemokine pathway activation. Remarkably, the expression of genes of innate immunity, complement, chemokines, immunoglobulin and regeneration genes was maintained or even increased in the long-standing cases. Transcriptomic data favour the view that T1D is caused by a chronic inflammatory process with a strong participation of innate immunity that progresses in spite of the regulatory and regenerative mechanisms.
Nanomanipulation with the Atomic Force Microscope (2010)

Abstract Manipulation with scanning probe microscopes has been under development for over a decade, and now provides the capability of building nanostructures automatically, from the bottom up, by assembling nanoscale objects such as particles, rods, and tubes. In this chapter, the current research on nanomanipulation is surveyed, with special emphasis placed on techniques that use the atomic force microscope (AFM) as a robot, the nanoscopic end‐effector of which – the tip – interacts directly with the nanoscale features of the sample. The principles of operation of the AFM, and the spatial uncertainties associated with it, are briefly described. Protocols for moving nano‐objects with the AFM tip are discussed, and experimental results presented which show that AFM manipulation can be used to accurately and reliably position molecular‐sized components. These can then be linked by chemical or physical means to form subassemblies, which in turn can be further manipulated. Interactive AFM manipulation systems are discussed, as well as recent results on automated nanomanipulation.
Selective induction, purification and characterization of a laccase isozyme from the basidiomycete<i>Trametes</i>sp. AH28-2 (2004)

The white-rot fungus Trametes sp. AH28-2 can synthesize extracellular laccase by induction in cellobiose-based liquid culture medium. Both yields and composition of laccase isozymes, produced by Trametes sp. AH28-2, would be quite different with induction by different small-molecule aromatic compounds, o-toluidine, guaiacol and 3,5-dihydroxytoluene, which affected microbial growth and the synthesis of laccase isozymes differentially. Higher concentrations of the three inducers could considerably increase laccase isozymes yields but not change the laccase composition. Coculturing of Trametes sp. AH28-2 with either Aspergillus oryzae or Gloeophyllum trabeum showed a few effects on laccase production. Laccase isozyme, laccase B, was selectively induced by 3,5-dihydroxytoluene and purified to homogeneity by two-step chromatography. Purified laccase B appeared as blue, with a broad peak at about 600 nm and a shoulder peak at about 330 nm. The ratio of absorbance at 280 nm to that at 600 nm was 21. Every molecule of laccase B had approximately four copper atoms. Molecular mass of laccase B was estimated to be 74 kDa on SDS-PAGE, 72 kDa by FPLC and was determined to be 71 454 Da by mass spectrum. After being treated with N-glycosidase F, laccase B lost 25% of its molecular mass. The isoelectric point of laccase B was 4.0. Its optimal pH and temperature for oxidizing guaiacol were respectively 4.7 and 45 C. The half-life of the enzyme at 60 C was 14.0 min. The enzyme showed a good stability in a range of pH value of 3.5-7.5. The K(m) values of the enzyme toward substrates syringaldazine, guaiacol, ABTS, and DMOP were respectively 28.0, 1249.0, 177.0 and 109.8 μM. The corresponding V(max) are 504.0, 1910.0, 117.4 and 159.0 μM min(-1) mg(-1). In addition, activity of laccase B was inhibited strongly by sodium azide and cyanide, mildly by SDS and trifluoroacetic acid, but only weakly by dimethyl sulfoxide.
Fuel Oil Manual (1986)

The properties of fuel oils.The possibilities and limitations of each grade.Methods which can be used to assure uniform quality and efficient combustion.Fuel oil impurities and how they affect combustion.How to diagnose and solve problems.This book is a Print-on-Demand edition. It replaces ISBN 978-0-8311-1166-3.This standard reference presents a broad scope of fuel oil technology. It uses both English and Metric units throughout.
Detection of a mouse H-<i>ras</i> codon 61 mutation using a modified allele-specific competitive blocker PCR genotypic selection method (1998)

A modified allele-specific competitive blocker PCR (ACB-PCR) has been developed as an approach for genotypic selection, the detection of a rare mutant allele based solely upon its altered nucleotide sequence. ACB-PCR genotypic selection operates through the preferential PCR amplification of mutant DNA using a primer that has more mismatches to the wild-type allele than the mutant allele. In addition, a blocker-primer with a 3'-terminal dideoxynucleotide and more mismatches to the mutant allele than the wild-type allele is incorporated to reduce the background and increase sensitivity. Using ACB-PCR, the CAA-->AAA base substitution at codon 61 of the mouse H-ras gene was detected regularly at mutant fractions of 10(-5). To accurately quantify the occurrence of this particular mutation, an internal amplification standard (AS) DNA was constructed. The H-ras and AS DNAs were subject to the same genotypic selection but were amplified using different upstream primers to give PCR products that can be distinguished by size. Defined mixtures of mutant and wild-type AS DNAs were used to study the effects of various components of the ACB-PCR. The concentration of dNTPs, blocker primer and Perfect Match Polymerase Enhancer, as well as the choice of thermostable DNA polymerase and annealing temperature were examined. Conditions were identified for the concurrent detection of the CAA-->AAA mutation in the H-ras and AS DNAs. Using the identified conditions, approximately equal signals were obtained from equivalent amounts of the two DNA templates over a wide range of mutant fractions (1 in 10 to 1 in 10(5)). This ACB-PCR method can be used for any application where it is necessary to quantify relatively small mutant fractions.
Microprocessor-based voltage controller for wind-driven induction generators (1990)

A microprocessor-based closed-loop system has been developed for wind-driven self-excited induction generators using a controlled rectifier to maintain a constant DC load voltage with varying rotor speeds. The configuration and implementation of the control scheme are described. Test results on a self-excited induction generator demonstrate the satisfactory performance of both the hardware and the software of the control scheme, and the utility of the set-up as a whole. The steady-state analysis of the generator is extended to include the controlled rectifier, and the performance characteristics are predicted.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A continuous wave transmission method for the ultrasonic spectrometry of liquids (1998)

A new variable-pathlength method that allows the ultrasonic attenuation coefficient of liquids to be precisely measured as a function of frequency is presented. Focusing on the effect of the sample liquid on the transfer function for continuous acoustical waves, this automated method is particularly useful because of its simple and easy-to-handle electronic set-up, essentially consisting of a computer-controlled network analyser only. The measuring procedure is described and constructional details of the specimen cell are shown. Possible sources of systematic errors are discussed together with depiction of some representative results. It is also explained how the usable frequency range of measurements can be extended towards lower frequencies by operating the apparatus at a fixed pathlength in the resonator mode.
An Evolutionary Approach to Learning in Robots (1994)

Evolutionary learning methods have been found to be useful in several areas in the development of intelligent robots. In the approach described here, evolutionary algorithms are used to explore alternative robot behaviors within a simulation model as a way of reducing the overall knowledge engineering effort. This paper presents some initial results of applying the SAMUEL genetic learning system to a collision avoidance and navigation task for mobile robots. 1 INTRODUCTION This is a progress report on our efforts to design intelligent robots for complex environments. The sort of applications we have in mind include sentry robots, autonomous delivery vehicles, undersea surveillance vehicles, and automated warehouse robots. In particular, we are investigating issues relating to machine learning, using multiple mobile robots to perform tasks such as playing hide-and-seek, tag, or competing to find hidden objects. Given the wide range of tasks in the area of robotics and learning, it may...
Macrophage colony-stimulating factor protects RAW264.7 cells from oxidative injury through the induction of MnSOD expression (2001)

To show the protective effect of macrophage colony-stimulating factor (M-CSF) on macrophages under oxidative stress, we investigated the effect of M-CSF on RAW264.7 cells incubated with tert-butyl hydroperoxide (tbOOH) using L929 cell conditioned medium (L929-CM) as the source of M-CSF. The results showed that M-CSF could alleviate the tbOOH- induced oxidative injury to RAW264.7 cells. We also found that M-CSF could improve superoxide dismutase (SOD) activity in the cells. MnSOD mRNA expression was also shown to be increased by RT-PCR technique, and the induction could be blocked by actinomycin D. So,we concluded that M-CSF could protect RAW264.7 cells from oxidative injury through inducing MnSOD expression.
Sweetener Preference Among Non-Institutionalized Older Adults (1995)

The purpose of this study is to determine the ability of a group of older adults to distinguish between a new artificial sweetener (Sweet One) and sucrose and to determine a sweetener preference among older adults. Participants (n = 112), 56-90 yrs. sampled a plain low-fat blended cottage cheese and iced tea sweetened with either sucrose or Sweet One arranged in a triangle test format. Participants also sampled four low-fat vanilla puddings sweetened with sucrose, Equal, Sweet'n Low, and Sweet One and ranked them according to preference. Results show participants are able to tell the difference between sucrose and the new artificial sweetener Sweet One in the iced tea drinks. Rank order results show this sample preferred Equal and sucrose as sweeteners. The ability to taste sweetness remains high in aging. Enhancing sweetness without added calories would aid nutritional well being of the elderly.
Status of tuberculosis health education in floating population with pulmonary tuberculosis (2010)

Objective To understand the situation and needs of TB health education in floating population with pulmonary tuberculosis. Methods Using a questionnaire to survey floating population of patients with tuberculosis.Content includes gender,age,educational level,occupation,the situation of TB knowledge as well as demand for health education. Results Less than half TB patient among floating population had ever received health education before discovery of tuberculosis,and no significant difference was found between different educational levels,gender,age groups.The demand rate of TB prevention,treatment and government policy knowledge are all exceeded 70%.For the approach of TB knowledge acquisition,the top four ways were health worker publicity,radio and television,newspapers and magazines,and posters.There was significant statistical difference in different educational levels in terms of approach of TB knowledge acquisition. Conclusions Better understanding the health education needs could make the health education work more tailored to the target population,thereby contributing to tuberculosis case detection improvement in floating population.
Amino‐Acid Sequence of the Cyanogen‐Bromide Fragment from Human Plasminogen that Forms the Linkage between the Plasmin Chains (1975)

The complete amino acid sequence of a cyanogen bromide fragment (122 residues) obtained from plasminogen is described. This fragment forms the overlap between heavy (A) and light (B) chains of human plasmin. The particular arginyl-valyl bond cleaved in the second step of the activation process is shown to be Arg98-Val99 in this fragment. This site is not very similar to the one in the NH2-terminal part of the molecule (Arg68-Met69). Remarkable homologies with the 'triple loops' ('kringle structures') found in the non-thrombin part of prothrombin are demonstrated. Homologies occurred during evolution of this chain.
Du droit à la santé aux Droits de l'Homme : le retour de l'ethnocentrisme (1987)

Constatant le récent développement des organisations humanitaires dans le champ de la santé, et leur dynamisme médiatique dans la société française, cet article s'interroge sur le sens et la portée de ce phénomène qui peut être caractérisé comme un « retour de l'occident » habillé de Droits de l'Homme. Après avoir rappelé les caractères de l'action sanitaire à l'époque coloniale — en particulier le fait que le contrôle sanitaire représente une pièce importante du dispositif colonial — l'auteur se penche en effet sur le passage du droit à la santé aux Droits de l'Homme, par lequel paraît s'opérer a reformulation d'une vision ethnocentrique négatrice des sociétés du Tiers Monde.
Encyclopedia of Computational Chemistry (1998)

Includes 500 complex illustrations in full color. Thorough cross referencing and Definition Entries (one paragraph dictionary articles). Reference list contains not only traditional material, but also FTP and HTTP sites and similar entries to electronic sources. Contributions from more than 300 leading computational chemists. von Rague Schleyer is also the editor of Wiley's well-known Journal of Computational Chemistry.
Pro‐inflammatory effects of hydrogen sulphide on substance P in caerulein‐induced acute pancreatitis (2007)

Hydrogen sulphide (H(2)S), a novel gasotransmitter, has been recognized to play an important role in inflammation. Cystathionine-gamma-lyase (CSE) is a major H(2)S synthesizing enzyme in the cardiovascular system and DL-propargylglycine (PAG) is an irreversible inhibitor of CSE. Substance P (SP), a product of preprotachykinin-A (PPT-A) gene, is a well-known pro-inflammatory mediator which acts principally through the neurokinin-1 receptor (NK-1R). We have shown an association between H(2)S and SP in pulmonary inflammation as well as a pro-inflammatory role of H(2)S and SP in acute pancreatitis. The present study was aimed to investigate the interplay between pro-inflammatory effects of H(2)S and SP in a murine model of caerulein-induced acute pancreatitis. Acute pancreatitis was induced in mice by 10 hourly intraperitoneal injections of caerulein (50 (g/kg). PAG (100 mg/kg, i.p.) was administered either 1 hr before (prophylactic) or 1 hr after (therapeutic) the first caerulein injection. PAG, given prophylactically as well as therapeutically, significantly reduced plasma H(2)S levels and pancreatic H(2)S synthesizing activities as well as SP concentrations in plasma, pancreas and lung compared with caerulein-induced acute pancreatitis. Furthermore, prophylactic as well as therapeutic administration of PAG significantly reduced PPT-A mRNA expression and NK-1R mRNA expression in both pancreas and lung when compared with caerulein-induced acute pancreatitis. These results suggest that the pro-inflammatory effects of H(2)S may be mediated by SP-NK-1R pathway in acute pancreatitis.
SceneCam: Improving Multi-camera Remote Collaboration using Augmented Reality (2019)

Systems for remote collaboration on physical tasks generally use AR/VR technologies to create a shared visual space for collaborators to perform tasks together. The shared space often comes from a single camera view. Prior research has not reported on the benefits of using multiple cameras for remote collaboration. On the contrary, there seems to be some usability issues, which must be addressed, when designing remote collaboration systems that use multiple cameras to capture different areas and perspectives of a task space. To be usable, a multi-camera remote collaboration system must indicate to the local user which camera the remote user is looking at and vice versa, the system must make it fast and easy for the remote user to obtain the right camera view for a given collaborative task. We present SceneCam, an AR prototype with which we explore different techniques for improving the usability of multi-camera remote collaboration by making camera selection easier and faster. Specifically, SceneCam implements two camera selection techniques. The first technique nudges the remote user to manually select an optimal camera view of the local user's actions. The second technique automatically selects an optimal camera view of the local user and shows it to the remote user. Additionally, SceneCam implements two focus-in-context views (exocentric and egocentric views) that provide the remote user with a spatial overview of the local user's whereabouts in relation to the multiple task space areas and direct visual access to the camera views of said areas. Camera selection techniques (manual point-and-click, nudging, automatic), and focus-in-context views (no focus-in-context view, exocentric, egocentric) make up the two dimensions in a design space for multi-camera remote collaboration. We describe how SceneCam spans this design space. Lastly, as part of future work we discuss some hypotheses regarding the effects of the proposed camera selection techniques, focus-in-context views and combinations hereof on the usability of multi-camera remote collaboration.
Mesh decomposition using motion information from animation sequences: Animating Geometrical Models (2005)

In computer graphics, mesh decomposition is a fundamental problem and it can benefit many applications. In this paper, we propose a novel mesh decomposition algorithm using motion information derived from a given animation sequence. The proposed algorithm first use principal component analysis (PCA) to construct a compact representation of a given animation sequence. Next, from this representation, we derive several motion parameters including motion complexity and similarity. Finally, we decompose a given mesh into sub-meshes using derived motion information and subdivide the triangles along the cutting paths for the smoother borders between the mesh parts. Our experimental results show that this new decomposition scheme can bring the benefit of good compression ratios on animation sequences. Copyright © 2005 John Wiley & Sons, Ltd.
Small-scale Energy-from-biomass Projects for Developing Countries - Are We Wasting Our Time? (1989)

Representative examples of small-scale energy-to-biomass programs are reviewed to determine to what extent they have been successful in reducing energy consumption. Factors hindering or promoting acceptance of new technologies, and their influence on future funding priorities are discussed.
131I-labeled antibodies to human fibrinogen.Diagnostic studies and therapeutic trials (1967)

Homologous 131I fibrinogen and its purified antibody will concentrate in a major portion of the neoplasms of the dogs and humans into which they are injected, according to new data. This report gives the scintillation scanning results obtained after iv administration of 131I-labeled and purified antihuman fibrinogen to 172 consecutive patients with various types of neoplasms. In 75% (129/172) of the cases the tumor, in various sites, was unequivocally located. These included mammary carcinomas (12/17), malignant melanoma (16/26), bronchogenic carcinoma (27/34), osteogenic sarcomas (9/9), hypernephromas (6/6), and primary tumors of the brain (10/18). The 131I deposition in tumor relative to normal tissue and blood was so great that in 12 terminal patients therapeutic trials were initiated using 100 to 160 me of the labeled antibody preparation. In some of these attempts, there was substantial remission of clinical symptoms. The usefulness of this technique for specific radiation therapy of tumors will be greatly improved when methods are developed for increasing 131I concentration in the peoplasm. Several approaches, including fever, endotoxin, pretreatment with fibrinolytic agents and post-treatment with antifibrinolytic agents, are under intensive investigation in experiments and offer great promise.