gebhart/patrepeval huggingface dataset:
Visible Electroluminescence from P-Type Crystalline Silicon/Porous Silicon/N-Type Microcrystalline Silicon Carbon PN Junction Diodes (1992)

We have fabricated p-type crystalline silicon/porous silicon/microcrystalline silicon carbon pn junction diodes and demonstrated current-induced visible light emission. We observed two kinds of electroluminescence; one was a weak white emission at a forward current of about 90 mA, and the other was a strong orange-red one at a forward current from about 200 to 619 mA.
Contribution a la caracterisation de psam2, un element genetique mobile de streptomyces (1990)

Psam2, un element genetique de 11 kb est present a l'etat integre dans la souche de streptomyces ambofaciens atcc23877 et a l'etat integre et libre dans la souche ji3212, un derive obtenu apres mutagenese au uv. Au cours d'un croisement interspecifique psam2 peut etre transfere dans s. Lividans et former des pocks, zones d'inhibition de croissance de la souche receptrice. Psam2 est capable d'augmenter le nombre de recombinants apres un croisement. L'integration de psam2 est de type site-specifique comme celle de certains bacteriophages temperes. La recombinaison a lieu entre deux sequences identiques de 58 pb presentes sur le plasmide (attp) et sur le chromosome (attb). Le gene codant pour la proteine impliquee dans l'integration de psam2 est situe pres du site attp. La proteine int predite presente une forte similarite avec les integrases des bacteriophages temperes. Une autre phase ouverte de lecture pourrait coder pour une proteine similaire aux excisionases (xis) impliquees dans l'excision site-specifique des bacteriophages temperes. Psam2 peut s'integrer dans toutes les souches de streptomyces testees ainsi que dans d'autres actinomycetes. La region chromosomique de differentes souches contenant le site d'attachement est conservee et elle peut etre repliee en structure caracteristique de l'arnt. Le gene putatif codant pour l'arnt proline n'est pas interrompu apres l'integration de psam2. L'integration de psam2 dans des genes d'arnt pourrait expliquer le large spectre d'hote de cet element. Le site att chromosomique de psam2 a ete localise genetiquement chez s. Ambofaciens et s. Lividans. Une carte fonctionnelle de psam2 a ete construite. Les fonctions de replication, de transfert et de formation des pocks sont situees dans des regions separees sur le plasmide. Le transfert de psam2 pourrait dependre de sa replication. Psam2 peut etre considere comme un element geneti
Windrose Planarity (2018)

Given a planar graph G and a partition of the neighbors of each vertex v in four sets v ↗ , v ↖ , v ↙ , and v ↘ , the problem W indrose P lanarity asks to decide whether G admits a windrose-planar drawing , that is, a planar drawing in which (i) each neighbor u ∈ v ↗ v is above and to the right of v , (ii) each neighbor u ∈ v ↖ is above and to the left of v , (iii) each neighbor u ∈ v ↙ is below and to the left of v , (iv) each neighbor u ∈ v ↘ is below and to the right of v , and (v) edges are represented by curves that are monotone with respect to each axis. By exploiting both the horizontal and the vertical relationship among vertices, windrose-planar drawings allow us to simultaneously visualize two partial orders defined by means of the edges of the graph. Although the problem is NP -hard in the general case, we give a polynomial-time algorithm for testing whether there exists a windrose-planar drawing that respects a given combinatorial embedding. This algorithm is based on a characterization of the plane triangulations admitting a windrose-planar drawing. Furthermore, for any embedded graph with n vertices that has a windrose-planar drawing, we can construct one with at most one bend per edge and with at most 2 n −5 bends in total, which lies on the 3 n × 3 n grid. The latter result contrasts with the fact that straight-line windrose-planar drawings may require exponential area.
Optimizing imaging in suspected appendicitis (OPTIMAP-study): A multicenter diagnostic accuracy study of MRI in patients with suspected acute appendicitis. Study Protocol (2010)

NTR2148.
ChemInform Abstract: HEXAMETHYLSILIRANE. I. PREPARATION, CHARACTERIZATION AND THERMAL DECOMPOSITION (1981)

Abstract Hexamethylsiliran (II) wird durch Umsetzung von Dimethyl‐bis‐(a‐bromoisopropyl)‐silan (I) mit elementarem Magnesium in Tetrahydrofuran dargestellt.
Exploring quadrangulations (2014)

We present a framework for exploring topologically unique quadrangulations of an input shape. First, the input shape is segmented into surface patches. Second, different topologies are enumerated and explored in each patch. This is realized by an efficient subdivision-based quadrangulation algorithm that can exhaustively enumerate all mesh topologies within a patch. To help users navigate the potentially huge collection of variations, we propose tools to preview and arrange the results. Furthermore, the requirement that all patches need to be jointly quadrangulatable is formulated as a linear integer program. Finally, we apply the framework to shape-space exploration, remeshing, and design to underline the importance of topology exploration.
Mathematical Analysis of Multi-Agent Systems (2004)

We review existing approaches to mathematical modeling and analysis of multi-agent systems in which complex collective behavior arises out of local interactions between many simple agents. Though the behavior of an individual agent can be considered to be stochastic and unpredictable, the collective behavior of such systems can have a simple probabilistic description. We show that a class of mathematical models that describe the dynamics of collective behavior of multi-agent systems can be written down from the details of the individual agent controller. The models are valid for Markov or memoryless agents, in which each agents future state depends only on its present state and not any of the past states. We illustrate the approach by analyzing in detail applications from the robotics domain: collaboration and foraging in groups of robots.
Histone Deacetylase Inhibitors: A Review of Their Clinical Status as Antineoplastic Agents (2005)

The histone code refers to specific modifications in the biochemical composition of nucleosome-associated histone proteins involved in the regulation of gene transcription. These modifications include, among several, acetylation, methylation, and phosphorylation of several histone amino acid residues and are associated with different states of chromatin configuration and gene expression. In particular, acetylation of specific residues in histones H3 and H4 has been associated with an open chromatin configuration and a permissive gene transcription state. This particular modification is regulated by several enzymatic activities with the capacity to either transfer acetyl groups or to induce histone deacetylation. This last activity is associated with gene silencing. Several agents have been shown to have histone deacetylase inhibitory activity (HDACI). In vitro, experiments in multiple neoplastic cancer cell lines have demonstrated that treatment with HDACIs results in increased global and gene specific histone acetylation, and reactivation of aberrantly silenced genes. This phenomenon has been associated with cell differentiation and induction of apoptosis. Based on these observations, several of these agents are now in clinical development both for solid tumor and hematological malignancies. In this article, we provide a brief introduction to the field of histone deacetylation inhibition in cancer and review the most relevant clinical data so far published.
The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion (2002)

Rran-dependent nuclear transport requires a nuclear pool of RanGTP both for the assembly of export complexes and the disassembly of import complexes. Accordingly, in order for these processes to proceed, Ran-dependent nuclear import and export assays in vitro require the addition of GTP to produce RanGTP. Notably, no ATP requirement can be detected for these transport processes in vitro. But in vivo, when cells are depleted of ATP by the addition of sodium azide and 2-deoxyglucose to block ATP production by oxidative phosphorylation and glycolysis, respectively, Ran-dependent nuclear import and export are rapidly inhibited. This raised the question of whether there is an ATP requirement for these nuclear transport pathways in an intact cell that has remained undetected in vitro. Here we report that the free (but not total) GTP concentration rapidly drops to an undetectable level upon ATP depletion as does the availability of RanGTP. Our conclusion is that the inhibition of Ran-dependent nuclear transport observed upon ATP depletion in vivo results from a shortage of RanGTP rather than the inhibition of some ATP-dependent process.
FREQUENCY AND CHARACTERISTICS OF SWIRLING NEGATIVE PLATELET CONCENTRATES (2003)

We have introduced the swirling test as a routine quality control of individual platelet concentrates (PC), in use since 1995. Of PC (127, 623 bags) examined in the last six years, 82 (0.064%) failed the swirling test. The swirling-negative PC bags tended to be obtained when 1) a certain apheresis machine was used for PC collection, 2) the PC donor was female and 3) the PC was obtained from a donor whose PC was swirling-negative at a previous donation. Of 141 PC donation from 12 such donors, 36 PC bags (25.5%) showed negative swirling.While swirling-negative PCs showing normal pH originally maintained their normal range for five days, the extent of their platelet shape change and morphology scores were significantly lower than those of normal PCs. There were no significant differences in aggregation activity or in the expression of activation markers (P-selectin and beta-TG).The cause of this type of negative swirling is unknown at present. The fact that PCs repeatedly showed negative swirling from the same donors suggest that a factor (s) of the donors may be associated with the loss of swirling.
Affordable technologies for utilization of methane in a landfill environment: An example of an integrated technology array and evolving institutional networks (2005)

CARIBELATE, the Caribbean Environmental Laboratory for the Advancement of Technological Entrepreneurship is an evolving institutional concept, as well as a physical complex, that provides a dynamic environment for public, academic and private sector organizations to conduct proof of concept technology demonstrations in a landfill environment. This article traces the successful networking of demonstrations at a landfill in New Jersey and the subsequent design of the CARIBELATE project in the Municipality of Carolina, Puerto Rico. The institutional model developed for the Puerto Rico facility has brought together an unlikely combination of stakeholders. Those from the private sector, here called industrial partners, are paired with academic researchers to optimize products for local markets. The basic technology system demonstrated in New Jersey and to be replicated in Puerto Rico removes harmful contaminants from landfill gas and in so doing produces a variety of useful products. A portion of the landfill gas is utilized for micro-turbine electricity generation and for heating a demonstration greenhouse that houses aquaculture coupled with hydroponic crop production, where aquaculture effluents are recycled as plant nutrients. A strict protocol to verify emission reduction is imposed on all the demonstrations at the CARIBELATE project. Although greenhouse gas credit verification is not the prime mission, it is suggested that the credits verified from these demonstrations are of high quality, and can serve as an excellent training platform. CARIBELATE is conceived to be operated at the municipal level and contribute to income generation and economic development. The continuing networking of stakeholders from the public and private sectors offers some potential guidance for replicating this design in the developing world.
Static synchronous compensator‐variable frequency drive for voltage and frequency control of small‐hydro driven self‐excited induction generators system (2014)

In this study, a static synchronous compensator (STATCOM) along with a variable frequency drive (VFD), is proposed for voltage and frequency control of a small‐hydro turbine driven self‐excited induction generator (SEIG) system. STATCOM is used to control SEIG terminal voltage through variable reactive power injection. A control algorithm based on adaptive noise cancellation filter is proposed for STATCOM control. A field oriented controlled VFD feeding an induction motor is used to control system frequency. The VFD consumes active power in excess of consumer loads and thereby it regulates the system frequency. The excess power consumed by the VFD is utilised for pumping water to either an overhead storage tank or irrigation purposes. Besides the voltage control as primary objective, the STATCOM also provides harmonic currents compensation and load balancing under unbalanced non‐linear loads. The proposed method of voltage and frequency control using STATCOM‐VFD combination is implemented on a 3.7 kW SEIG and the test results are presented to demonstrate its performance.
ChemInform Abstract: Enantioselective Oxidation of Thioethers. Part 8. An Improved Route to the Resolution of (1,1′‐Binaphthalene)‐2,2′‐dithiol (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mucosa-Associated Lymphoid Tissue-Type Lymphomas Occurring in Post-Transplantation Patients (2000)

Post-transplantation lymphoproliferative disorders (PTLDs) are usually Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders that vary in their morphologic spectrum. Extranodal marginal zone lymphomas of the mucosa-associated lymphoid tissue-type (MALT-type) have not been considered to be part of this spectrum. The authors encountered five such cases recently. The clinical, histopathologic, and immunophenotypic features are reported. There were three men and two women with a mean age of 51.2 years (range, 48-63 years). Two patients were cardiac transplant recipients, two patients were liver transplant recipients, and the remaining patient was a renal transplant patient. Sites of lymphoma were the stomach in three patients and the parotid gland in two patients. Mean time to the lymphoma was 84 months after transplantation. All patients had morphologic features of low-grade extranodal marginal zone lymphomas of the MALT-type, and Helicobacter pylori was present in all three gastric cases. All patients exhibited the B-cell immunophenotype and were negative for EBV by in situ hybridization. These lymphomas were treated with a variety of modalities, including reduction of immunosuppression, antibiotics, surgical resection, radiation therapy, and chemotherapy. At last follow-up, one patient had developed signet ring adenocarcinoma at 27 months but had no evidence of PTLD, one patient relapsed at 17 months but is alive with stable disease at 24 months, and the remaining patients were alive without disease at 11, 12, and 14 months. Extranodal low-grade MALT-type lymphomas can occur in the post-transplantation setting and generally develop years after transplant. As seen in immunocompetent patients, EBV appears to play no role in the pathogenesis of these lymphomas. These lymphomas appear to have more in common with MALT-type lymphomas in nonimmunocompromised patients than conventional PTLDs, although they occur in "at-risk" patients due to their immunosuppressive therapy. These lymphomas do not appear to be clinically aggressive. Recognition of MALT-type lymphomas in the post-transplantation setting as an indolent disease avoids unnecessary treatment.
FLASH PHOTOLYSIS OF TRYPTOPHAN AND N‐ACETYL‐L‐TRYPTOPHANAMIDE; THE EFFECT OF BROMIDE ON TRANSIENT YIELDS (1977)

Abstract— The initial yields of the cation and neutral radicals and the triplet are greatly enhanced when high concentrations of Br ‐ are present during the flash photolysis of aqueous solutions containing either tryptophan or N‐acetyl‐L‐trytophanamide. The present study is an attempt to elucidate the mechanism by which Br ‐ induces these effects. The results obtained indicate that the initial event involves an interaction between the fluorescent state and Br ‐ to promote the formation of a long‐lived radical precursor that may be the triplet. It is shown that all of the Br ‐ ‐induced neutral and cation radical formation originate from this long‐lived state. Furthermore, it was found that the mechanism of radical production from the Br ‐ ‐induced long‐lived precursor does not involve hydrated electron formation.
The atrial natriuretic factor in mild essential hypertension. (1987)

Small granules are seen around the poles of the nuclei of most cells of the heart atria of all mammalian species including men. They contain proteinaceous material and their number varies with sodium and water balance (1). Their significance became clear with the observation in 1981 of de Bold, et al. that crude homogenates of rats' atria, when injected into normal rats, produced a rapid, massive and short lasting diuresis, natriuresis, and vasorelaxation, with a decrease in mean arterial pressure (2). Since this finding, progress in this field has been extremely rapid. Several small peptides of varying length, but having the same core of 21 amino acids have been isolated by various groups. The major circulating form of atrial natriuretic factor (ANF) is a 28 amino acid peptide (Ser 99-Tyr 126) both in rat and in man (3-5). This peptide shows almost complete homology between various species, the only difference being a methionine group in position 110 in cattle, dog, and man instead of the isoleucine found in rat, mouse and rabbit (Fig. 1). The major effects of ANF (or more appropriately CNF, cardiac natriuretic factor, because of the presence of the ANF gene and of mRNA in heart ventricles [6-8]) are a) renal, with a marked diuresis and natriuresis resulting mostly from an increased glomerular filtration rate and filtration fraction, b) vascular, resulting in selective vasodilatation in some territories and not in others, c) adrenal, with inhibition of aldosterone liberation, d) cerebral with important concentrations of immunoreactiveANF in the AV3V region and also in the retina and olfactory bulb. Studies of ANF in relation to human hypertension are therefore relevant, especially so since previous work by Garcia and our group in rats (9-11) and others in dogs, especially Kleinert, et al. (12), Granger, et al. (13), and Seymour, et al. (14) have shown that administration of ANF either by bolus injection or by continuous infusion, results in a significant decrease in blood pressure in hypertensive rats (2K-1C, 1K-
Energy-Efficient Long-term Continuous Personal Health Monitoring (2015)

Continuous health monitoring using wireless body area networks of implantable and wearable medical devices (IWMDs) is envisioned as a transformative approach to healthcare. Rapid advances in biomedical sensors, low-power electronics, and wireless communications have brought this vision to the verge of reality. However, key challenges still remain to be addressed. The constrained sizes of IWMDs imply that they are designed with very limited processing, storage, and battery capacities. Therefore, there is a very strong need for efficiency in data collection, analysis, storage, and communication. In this paper, we first quantify the energy and storage requirements of a continuous personal health monitoring system that uses eight biomedical sensors: (1) heart rate, (2) blood pressure, (3) oxygen saturation, (4) body temperature, (5) blood glucose, (6) accelerometer, (7) electrocardiogram (ECG), and (8) electroencephalogram (EEG). Our analysis suggests that there exists a significant gap between the energy and storage requirements for long-term continuous monitoring and the capabilities of current devices. To enable energy-efficient continuous health monitoring, we propose schemes for sample aggregation, anomaly-driven transmission, and compressive sensing to reduce the overheads of wirelessly transmitting, storing, and encrypting/authenticating the data. We evaluate these techniques and demonstrate that they result in two to three orders-of-magnitude improvements in energy and storage requirements, and can help realize the potential of long-term continuous health monitoring.
Enhanced Laminin-Derived Peptide AG73-Mediated Liposomal Gene Transfer by Bubble Liposomes and Ultrasound (2009)

A promising strategy as a cancer therapeutic is tumor-targeted gene delivery. The AG73 peptide derived from the laminin alpha1 chain is a ligand for syndecans, and syndecan-2 is highly expressed in some cancer cells. In this study, AG73-PEG liposomes were developed for selective gene delivery to syndecan-2 overexpressing cancer cells. AG73-PEG liposomes were used in combination with Bubble liposomes and ultrasound exposure to enhance transfection efficiency by promoting the escape of the liposomes from the endosome to the cytosol. AG73-PEG liposomes showed selective gene delivery to syndecan-2 overexpressing cancer cells. Furthermore, AG73-mediated liposomal gene transfection efficiency was enhanced by 60-fold when Bubble liposomes and ultrasound exposure were used, despite the absence of an increase in the uptake of AG73-PEG liposomes into the cells. Confocal microscope analysis revealed that the Bubble liposomes and ultrasound promoted intracellular trafficking of the AG73-PEG liposomes during gene transfection. Thus, the combination of AG73-PEG liposomes with Bubble liposomes and ultrasound exposure may be a promising method to achieve selective and efficient gene delivery for cancer therapy.
Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 ( <scp>SGLT2</scp> ) inhibitor, in subjects with renal impairment (2013)

Renal insufficiency resulted in decreased CLR of empagliflozin, moderately increased systemic exposure and decreased UGE. A single 50 mg dose of empagliflozin was well tolerated in subjects with normal renal function and any degree of renal impairment. The pharmacokinetic results of this study indicate that no dose adjustment of empagliflozin is required in patients with renal impairment.
Experimental and numerical investigation of expanded polystyrene (EPS) geofoam samples under monotonic loading (2020)

The recent increase in the use of Expanded Polystyrene (EPS) geofoam in construction and geotechnical projects has driven researchers to investigate its behavior, more deeply. In this paper, a series of experimental tests to investigate the stress-strain behavior and the mechanical properties of EPS blocks, under monotonic axial loading are presented. Four different densities of cylindrically shaped EPS with different dimensions are used to investigate the effects of loading rate, height and diameter, as well as the influence of the density of EPS on the stress-strain response. The results show that increasing the height of the EPS samples leads to instability of the sample and consequent lower resistance to the applied pressure. Large EPS samples show higher Young’s modulus and compressive resistance due to some boundary effects. An increase in the rate of loading can increase the elastic moduli and compressive resistance of the EPS geofoam samples, which also varies depending on the density of the samples. It was also determined that the elastic modulus of EPS increases with increasing EPS density. By implementing an efficient numerical procedure, the stress-strain response of EPS geofoam samples can be reproduced with great accuracy. The numerical analysis based on the proposed method can used to evaluate the effect of different factors on the behavior of EPS geofoam