gebhart/patrepeval huggingface dataset:
In Vitro Pharmacology of DuP 753 (1991)

DuP 753, 2-n-butyl-4-chloro-5-hydroxymethyl-1-[2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]imidazole, potassium salt, was characterized in vitro with respect to its affinity and specificity for functional antagonism of angiotensin II (AII) receptors. In rat adrenal cortical microsomes and cultured aortic smooth muscle cells DuP 753 inhibited the specific binding of [125I]AII in a concentration-dependent manner yielding IC50 values of 1.7 and 2.0 x 10(-8) mol/L, respectively. In contrast, DuP 753 had no appreciable affinity for other receptor systems as well as for Ca2+ channels. Functional antagonism was demonstrated by its blockade of AII-induced 45Ca2+ efflux in rat smooth muscle cells. The AII-induced contraction of rabbit aortic strips was competitively antagonized by DuP 753 resulting in a pA2 value of 8.48. Responses induced by other agonists, such as norepinephrine and KCl, were not altered. No partial agonistic effect was noted in any of the in vitro assays. In addition, DuP 753 (10(-5) mol/L) had no effect on rabbit lung converting enzyme or rat/human renin activity. These data demonstrate that DuP 753 is a highly potent and specific AII receptor antagonist. DuP 753 represents a useful experimental tool for dissecting the role of the renin-angiotensin system.
Bis(imino)pyridines fused with 6- and 7-membered carbocylic rings as <i>N</i>,<i>N</i>,<i>N</i>-scaffolds for cobalt ethylene polymerization catalysts (2019)

The unsymmetrical diketone, 1,2,3,7,8,9,10-heptahydrocyclohepta[b]quinoline-4,6-dione, based on a central pyridine unit fused by both 6- and 7-membered rings, has been synthesized via a sequence of reactions including ruthenium-catalyzed coupling cyclization. Templating this diketone with a mixture of cobalt(ii) chloride hexahydrate and the corresponding aniline in acetic acid at reflux afforded five examples of carbocyclic-fused bis(arylimino)pyridine-cobalt(ii) chlorides (aryl = 2,6-Me2Ph Co1, 2,6-Et2Ph Co2, 2,6-i-Pr2Ph Co3, 2,4,6-Me3Ph Co4, 4-Me-2,6-Et2Ph Co5) in good yield. All cobalt complexes have been fully characterized including by 1H NMR spectroscopy which reveals broad but assignable paramagnetically shifted peaks. The molecular structures of Co1, Co3 and Co4 highlight the inequivalency of the two fused rings with the cobalt center adopting a distorted trigonal bipyramidal geometry. Treatment of Co1-Co5 with MAO gave highly active catalysts (up to 5.03 × 106 g PE mol-1 (Co) h-1 at 40 °C, with Co4 > Co5 > Co1 > Co2 > Co3) for ethylene polymerization generating strictly linear vinyl-terminated polymers with low molecular weights (Mw range: 1.53-22.77 kg mol-1). By comparison, polymerizations conducted using Co1-Co5/MMAO were less active and displayed a lower selectivity for unsaturated polymers. Common to both MAO and MMAO, the most sterically hindered precatalyst Co3 gave the highest molecular weight polymer of the series (up to 22.77 kg mol-1) but exhibited the lowest activity.
The use of compound continuous flow diffusion chemostats to study the interaction between nitrifying and nitrate-reducing bacteria (1985)

The interactions occuring between populations of a nitrate-respiring Vibrio sp. and autotrophic nitrifying bacteria belonging to the genera Nitrosomonas and Nitrobacter have been investigated in a compound bi-directional flow diffusion chemostat at a dilution rate of 0.025 h−1 and a temperature of 25°C. When grown under NO−3 limitation, the Vibrio sp. produced NH+4 as the principal end-product of nitrate respiration, and there was a corresponding significant increase in cell numbers of the Nitrosomonas sp. population, which derived energy by the oxidation of NH+4 to NO−2. Nitrite in turn was used by the Nitrobacter sp. population as an energy source with the concomitant regeneration of NO−3. Under NO−3 excess growth conditions the Vibrio sp. produced NO−2 rather than NH+4 as the major product of NO−3 dissimilation, and growth of the Nitrobacter population was stimulated as increased quantities of NO−2 became available. In contrast, the Nitrosomonas sp. population declined sharply as the energy source NH+4 became limiting. These data demonstrate that defined mixed populations of obligately aerobic nitrifying bacteria and facultatively anaerobic nitrate respiring bacteria can co-exist for extended time periods and operate an internal nitrogen cycle which is energetically beneficial to both populations.
Nonlinear optical properties of quantum-confined GaAs nanocrystals in Vycor glass (1992)

Quantum-confined nanocrystallites of GaAs are fabricated in porous Vycor glass and the bound electronic nonlinear refractive index, the two-photon absorption coefficient, and the refraction from carriers generated by two-photon absorption are simultaneously determined using the Z-scan method and compared to those of bulk GaAs. The measured nonlinear refractive index is an order of magnitude larger than that of bulk GaAs at 1060 nm.
Identification of bacterial transporters for hydroxyalkylcysteinylglycines (2014)

The generation of malodour in the human underarm (axilla) is caused by bacterial biotransformation of specific malodour precursor molecules contained within non-odorous apocrine gland secretions. The dipeptide-conjugated thioalcohol, (S)-(1-(2-hydroxyethyl)-1-methylbutyl)-L-cysteinylglycine (Cys-Gly-3M3SH) is known to be secreted into the axilla and biotransformed into the highly volatile thioalcohol 3-methyl-3-sulfanylhexan-1-ol (3M3SH) by members of the axillary microbiota, consisting principally of the genera Corynebacterium and Staphylococcus. However, the exact bacterial species that carry out this biotransformation have not been thoroughly characterised. Additionally, the route by which malodour precursor molecules are transported across the bacterial cell membrane to the cytoplasm have not been assessed, and a general disagreement within the literature is evident regarding the intracellular catabolic fate of such molecules.\n\nHere, malodour precursor biotransformation data is presented from a library of skin isolated corynebacteria and staphylococci which identified significant variations in thioalcohol production across individual bacterial species and strains. Three Staphylococcus species, S. hominis, S. haemolyticus and S. lugdunensis were the strongest Cys-Gly-3M3SH biotransformers whereas all Corynebacterium spp. assessed showed weak or absent catabolism of this substrate. The molecular basis of uptake and biotransformation of dipeptide-conjugated malodour precursor compounds in the model organism Escherichia coli K-12 was assessed by creating and characterising peptide transporter deficient strains, which revealed novel phenotypes for several poorly studied peptide transporters in this organism. The relevant E. coli strains were then used as a background to overexpress and characterise putative dipeptide-conjugated malodour precursor transporters from a strong malodour producing S. hominis isolate. This revealed that a general S. hominis peptide transporter mediates Cys-Gly-3M3SH uptake. An in silico analysis of putative Cys-Gly-3M3SH catabolic genes revealed a novel cystathionine β-lyase-like gene present only in those Staphylococcus species able to biotransform Cys-Gly-3M3SH, strongly suggesting an involvement in Cys-Gly-3M3SH biotransformation.\n\nThis work provides major advances in understanding the molecular basis of human axillary malodour.
Recommendation for key management, part 1 : (2007)

This Recommendation provides cryptographic key management guidance. It consists of three parts. Part 1 provides general guidance and best practices for the management of cryptographic keying material. Part 2 provides guidance on policy and security planning requirements for U.S. government agencies. Finally, Part 3 provides guidance when using the cryptographic features of current systems.
A quantitative electron microscopic study of the crystalline structure of ethylene copolymers (1986)

Abstract Quantitative thin‐section electron microscope studies were made on compositional fractions of ethylene copolymers crystallized under several extreme conditions. The co‐units chosen were such that the chains contained either ethyl, hexyl, or acetate side groups. Certain general features are independent of the chemical nature of the co‐unit. It was found that up to about 2 mol % co‐unit content lamellae are observed in all copolymers which were slowly cooled from the melt. The lateral dimensions of lamellae are not as large as in corresponding homopolymers and the lamellae are segmented. As the branch content increases the lamellae become shorter and eventually degrade into small crystallites. Within this broad outline of behavior, differences between the copolymer types are discerned and discussed. By comparison with the Raman LAM it is shown that quantitative values for the crystallite size distribution are obtained by the electron microscopy method used. Furthermore, when the specimen consisted of well‐ordered lamellar stacks the degree of crystallinity obtained from the electron micrographs was in quantitative agreement with the enthalpy of fusion.
ChemInform Abstract: HALOGENMETHYL‐METALL‐VERBINDUNGEN 46. MITT. RK. VON PHENYL‐BROMDICHLORMETHYL‐QUECKSILBER MIT HETEROATOM‐KUMULENEN (1971)

Abstract Diisopropylcarbodiimid (I) reagiert mit Phenyl‐dichlorbrommethyl‐quecksilber (II) im wesentlichen zum Isocyaniddichlorid (III) neben geringeren Mengen an Isonitril (IV) und dem Phenylquecksilberbromid (V).
Spatiotemporal stability of two beetle populations in non‐farmed habitats in an agricultural landscape (2006)

Summary Understanding the spatiotemporal ecology of invertebrates in agricultural ecosystems is important for developing management strategies to enhance biodiversity and reduce pesticide use. There is increasing recognition that studies need to be undertaken at scales larger than the field but the ability to do this is often resource limited. Pheromone traps, developed for pest management, can provide a relatively cheap means of collecting data across wide geographical scales. In this study we used such traps to examine the spatial stability of two species of agrioted beetles in non‐farmed habitats over a period of 3 years. The spatial distributions of adult male Agriotes lineatus and Agriotes obscurus were sampled from April until July at a number of sites across 950 ha on Westham Island, British Columbia, Canada. Data were assembled as spatially referenced cumulative trap counts by species and year, and analysed for evidence of aggregation and clustering using spatial analysis by distance indices (SADIE) methodology. Both intraspecific and interspecific association analyses were then carried out. A further set of analyses considered the spatial associations between different sampling dates in 2004. Agriotes lineatus was clustered into patches and gaps at the landscape scale in all 3 years, and A. obscurus showed similar spatial structure in 2002 and 2003. For both species, spatiotemporal stability at the landscape scale was evident. There was also a positive association between the two species in 2 out of the 3 years, suggesting that they were responding in a similar manner to the landscape environment. Synthesis and applications . This study showed that there was substantial temporal stability in the spatial structures of A. lineatus and A. obscurus in non‐farmed habitats, and that the two species respond in a broadly similar way to a heterogeneous agricultural landscape. This suggests that models to predict distributions within a landscape could be developed to guide decisions about where to grow vulnerable crops. Identification of the environmental factors that differentiate between clusters and gaps in their spatial distributions may also make it possible to manipulate populations and reduce their impact as pests without recourse to insecticides. Moreover, our results extend the spatial scales over which SADIE statistics have been used, and demonstrate the usefulness of pheromone trapping as a sampling method in addressing ecological questions at a landscape scale.
Enabling 10&#x00B5;m pitch hybrid Cu-Cu IC stacking with Through Silicon Vias (2010)

Recently imec demonstrated for the first time 3D integrated circuits obtained by die-to-die stacking using Cu Through Silicon Vias (TSV) on 200 mm wafers. The top tier dies are thinned down to 25 μm and bonded to the landing wafer by Cu-Cu thermo-compression. Nevertheless, the path towards high volume manufacturing remains to be established. In this paper, we report about fundamental integration issues and discuss possible solutions for further process optimization. The implementation of the proposed solution substantially increased the electrical yield of Cu-Cu joining.
Surface Diffusion of Sulfur on Oxygen-Covered Tungsten Studied by Auger Electron Spectroscopy (1984)

By the electron-beam bombardment of a tungsten surface in an ultrahigh vacuum, we can obtain the surface distribution of sulfur, which localizes at the area of bombardment. Utilizing this phenomenon as a method of depositing localized sulfur, a study was performed by Auger electron spectroscopy on the surface diffusion of sulfur on a polycrystalline tungsten ribbon surface covered with roughly half a monolayer of oxygen. As a result, the activation energy for the surface diffusion of sulfur was determined as 1.03±0.04 eV.
Ruthenium η<sup>4</sup>-Trimethylenemethane Complexes Containing Tripodal Phosphanomethylamine Ligands (2012)

Ruthenium η4-trimethylenemethane complexes containing two different tridentate phosphine ligands have been synthesized. The formation of the complexes using [Ru(η4-COD)(η3-CH2CMeCH2)2] as the metal precursor occurred via elimination of isobutene. An intermediate species has been isolated in which the ligand coordinates with only two phosphorus atoms. Furthermore, protonation of the trimethylenemethane ligand gave rise to a cationic methylallyl complex.
Continuous Treatment of Textile Water by Ozonation and Coagulation (1994)

A continuous process of combined ozonation and chemical coagulation was employed for treatment of textile wastewaters from several dyeing and finishing plants. Ozonation was found to be highly effective in color removal with complete discolorization of textile wastewater being achieved in less than 10 min in the continuous reactor. Chemical coagulation was observed to be mainly responsible for removing dissolved and suspended solids with a COD removal efficiency of up to 66%. The treatment efficiency of the combined process can be further enhanced when used in conjunction with the activated sludge process. Preliminary economic analysis of the process shows that ozonation for decolorization is highly competitive in terms of its total cost compared with use of decoloring agent. The cost saving is further complemented by a considerable improvement in the overall quality of the treated wastewater.
Enantiospecific Synthesis of α,β-Diamino Acids via Rhodiumcatalyzed Intramolecular Formation of N-Sulfamoyl 2,3- Aziridino-γ-lactones (2013)

Many examples of α,β-diamino acids are found in nature or as components of natural products and their core structure is part of a wide variety of therapeutically useful drugs. 2,3-Aziridino-γ-lactones have been shown to be valuable starting materials for the preparation of a- and b-amino acids. In this work, we wish to report the intramolecular aziridination of sulfamates derived from butenolide 1 as well as its 2-methyl derivative 2 to obtain 2,3- aziridino-γ-lactones. The reactivity of the latter toward nucleophiles and application of the procedure to the synthesis of α,β-diamino acids were subsequently studied.
Optical tomography by the temporally extrapolated absorbance method (1996)

The concept of the temporally extrapolated absorbance method (TEAM) for optical tomography of turbid media has been verified by fundamental experiments and image reconstruction. The TEAM uses the time-resolved spectroscopic data of the reference and object to provide projection data that are processed by conventional backprojection. Optical tomography images of a phantom consisting of axisymmetric double cylinders were experimentally obtained with the TEAM and time-gating and continuous-wave (CW) methods. The reconstructed TEAM images are compared with those obtained with the time-gating and CW methods and are found to have better spatial resolution.
Utilizing Dynamic Stability to Orient Parts (1987)

The intent of this research is to study the dynamic behavior of a solid body resting on a moving surface. Results of the study are then used to propose methods for controlling the orientation of parts in preparation for automatic assembly. Two dynamic models are discussed in detail. The first examines the impacts required to cause reorientation of a part. The second investigates the use of oscillatory motion to selectively reorient parts. This study demonstrates that the dynamic behaviors of solid bodies, under the conditions mentioned above, vary considerably with small changes in geometry or orientation.
Evaluating the impact of fractures on the long-term performance of the In Salah CO2 storage site (2009)

The In Salah Gas Joint Venture CO2 storage project has been in operation in Algeria since 2004 and is currently the world's largest onshore CO2 storage project. CO2 is injected into a saline aquifer of a gas reservoir several km away from the gas producers. Current focus in the project is on implementing a comprehensive monitoring strategy and modelling the injection behaviour in order to ensure and verify safe long-term storage. A key part of this effort is the understanding of the processes involved in CO2 migration within relatively low-permeability sandstones and shales influenced by fractures and faults. We summarise our current understanding of the fault and fracture pattern at this site and show preliminary forecasts of the system performance using Discrete Fracture Models and fluid flow simulations. Despite evidence of fractures at the reservoir/aquifer level, the thick mudstone caprock sequence provides an effective flow and mechanical seal for the storage system; however, quantification of the effects of fracture flow is essential to the site verification.
Porphyrins. 43. Triplet sublevel emission of platinum tetrabenzoporphyrin by spectrothermal principal component decomposition (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPorphyrins. 43. Triplet sublevel emission of platinum tetrabenzoporphyrin by spectrothermal principal component decompositionThijs J. Aartsma, Martin Gouterman, Clemens Jochum, Alvin L. Kwiram, Barry V. Pepich, and Loren D. WilliamsCite this: J. Am. Chem. Soc. 1982, 104, 23, 6278–6283Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/ja00387a021https://doi.org/10.1021/ja00387a021research-articleACS PublicationsRequest reuse permissionsArticle Views321Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IM-DB: Information retrieval system for interactive network-status analysis (2010)

To manage the changing conditions of the Internet and diagnose the cause of anomalies within it, network operators must obtain and analyze information from network devices such as routers and network monitoring tools. Of that information, route information exchanged by Border Gateway Protocol (BGP) is essential for understanding the Internet at an inter-autonomous-system (AS) level. However, the information is not easily deployed for actual network management because of the enormous amount of the information and the difficulties in manipulating it. To overcome these problems, we propose IM-DB, a network information retrieval system for the interactive analysis and diagnosis of the Internet. Our IM-DB is based on a relational database and can store large amount of network information. By using the IM-DB, network operators can easily search, integrate, and explore information they require. We developed the first version of our IM-DB for storing BGP routing information. The experimental results using this prototype demonstrate the feasibility of our IM-DB.
Abundance, Distribution, and Transcriptional Activity of Repetitive Elements in the Maize Genome (2001)

Long terminal repeat (LTR) retrotransposons have been shown to make up much of the maize genome. Although these elements are known to be prevalent in plant genomes of a middle-to-large size, little information is available on the relative proportions composed by specific families of elements in a single genome. We sequenced a library of randomly sheared genomic DNA from maize to characterize this genome. BLAST analysis of these sequences demonstrated that the maize genome is composed of diverse sequences that represent numerous families of retrotransposons. The largest families contain the previously described elements Huck, Ji, and Opie. Approximately 5% of the sequences are predicted to encode proteins. The genomic abundance of 16 families of elements was estimated by hybridization to an array of 10,752 maize bacterial artificial chromosome (BAC) clones. Comparisons of the number of elements present on individual BACs indicated that retrotransposons are in general randomly distributed across the maize genome. A second library was constructed that was selected to contain sequences hypomethylated in the maize genome. Sequence analysis of this library indicated that retroelements abundant in the genome are poorly represented in hypomethylated regions. Fifty-six retroelement sequences corresponding to the integrase and reverse transcriptase domains were isolated from approximately 407,000 maize expressed sequence tags (ESTs). Phylogenetic analysis of these and the genomic retroelement sequences indicated that elements most abundant in the genome are less abundant at the transcript level than are more rare retrotransposons. Additional phylogenies also demonstrated that rice and maize retrotransposon families are frequently more closely related to each other than to families within the same species. An analysis of the GC content of the maize genomic library and that of maize ESTs did not support recently published data that the gene space in maize is found within a narrow GC range, but does indicate that genic sequences have a higher GC content than intergenic sequences (52% vs. 47% GC).