gebhart/patrepeval huggingface dataset:
Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats (1985)

In the rat hippocampal formation, degeneration of CA4-derived afferent fibers provokes the growth of mossy fiber collaterals into the fascia dentata. These aberrant fibers subsequently form granule cell-granule cell synapses. The hippocampal slice preparation was employed to determine whether these recurrent connections are electrophysiologically functional. Hippocampal slices were prepared 12 to 21 days after the bilateral destruction of CA4 neurons with either intracerebroventricular or intravenous kainic acid (KA). In slices from control rats, antidromic stimulation of the mossy fibers elicited a single population spike in the granular layer of the fascia dentata. In contrast, when slices from some KA-treated rats were similarly tested, antidromic stimulation elicited multiple population spikes. This effect was not reproduced by blocking inhibitory transmission with bicuculline methiodide. Slices from other KA-treated rats fired a single population spike, but an antidromic conditioning volley increased the amplitude of a subsequent antidromic population spike by 5 to 15%. In slices from control rats, on the other hand, an antidromic conditioning volley always either decreased or failed to alter the amplitude of an antidromic test response. Superfusion with Ca2+-free medium containing 3.8 mM Mg2+ reversibly abolished all effects of KA administration. Abnormal responses to antidromic stimulation correlated with the loss of CA4 neurons and the growth of supragranular mossy fiber collaterals in the same animals. These results suggest that supragranular mossy fiber collateral sprouts form a functional recurrent excitatory circuit. These aberrant connections may further compromise hippocampal function already disrupted by neuronal degeneration, such as by facilitating seizure activity.
Intracranial Complications of Sinusitis (1997)

Intracranial suppurative complications of sinusitis remain a challenging and contemporary topic. To determine the prevalence of sinogenic sources in intracranial infectious complications, we reviewed the records at a large public hospital between 1985 and 1995. There were 203 patients with 212 suppurative intracranial infections. Sinogenic sources were identified in 12 patients with 19 infections. Most patients had ethmoid or frontal sinusitis. We discuss the presentation, microbiology, diagnosis, treatment, and clinical course of these 12 cases. The diagnosis of intracranial complications of sinusitis requires a high index of suspicion and radiographic imaging of the head and paranasal sinuses. The mean hospital stay was 31.4 days and all 12 patients survived, although three patients had significant neurologic sequelae.
Legislative Review (1990)

Journal For Healthcare Quality: July 1990 - Volume 12 - Issue 3 - p 42-43 doi: 10.1111/j.1945-1474.1990.tb00066.x
Review of Laboratory Findings for Patients with Chronic Fatigue Syndrome (1991)

Various abnormalities revealed by laboratory studies have been reported in adults with chronic fatigue syndrome. Those most consistently reported include depressed natural killer cell function and reduced numbers of natural killer cells; low levels of circulating immune complexes; low levels of several autoantibodies, particularly antinuclear antibodies and antithyroid antibodies; altered levels of immunoglobulins; abnormalities in number and function of lymphocytes; and modestly elevated levels of two Epstein-Barr virus-related antibodies, immunoglobulin G to viral capsid antigen and to early antigen.
Cutaneous T cell lymphoma: characterization by monoclonal antibodies (1981)

Monoclonal antibodies to human T cells permit the characterization of the surface phenotype of cutaneous T cell lymphoma (CTCL). The majority of CTCL cells are reactive with OKT1 and OKT3 monoclonals, which identify peripheral T cells and mature thymocytes. The neoplastic cells also react with OKT4, which recognizes the inducer T cell subset; they are, however, unreactive with OKT5 monoclonal, which identifies cytotoxic/suppressor T cell subsets. These data are in agreement with previous functional studies demonstrating that CTCL is a neoplasm of inducer (helper) T cells.
Determination of Magnesium and Calcium in Biological Samples by Potentiometric Stripping Analysis (2010)

Abstract A new and simple method for determination of calcium and magnesium in human plasma and hair samples was investigated by using potentiometric stripping analysis. The replacement reactions between Ca 2 + and Zn‐EGTA (Ethylene glycol‐bis‐(2‐aminoethyl)tetraacetic acid) complex and between Mg 2 + and Zn‐EDTA (Ethylenediamine tetraacetic acid disodium salt) complex were utilized. The determinations were carried out in NH 4 Cl‐NH 3 buffer solutions of pH 9.54 for calcium and of pH 10.18 for magnesium, respectively. Potential and time data were digitally converted into d t d E −1 , and E was plotted vs. d t d E −1 . Quantitative analysis was carried out by the method of standard additions. Linearity for determination of magnesium was found to be in the range of 6∼120 μg L −1 with a correlation coefficient of 0.997 ( n = 6); and for determination of calcium in the range of 10∼250 μg L −1 with a correlation coefficient of 0.995 ( n = 6). The detection limit of 4 μ gL −1 was found for both magnesium and calcium determination. This proposed method has been used for determining calcium and magnesium in biological samples with good recoveries and well accord with the results of Inductively Coupled Plasma‐Atomic Emission Spectrometry (ICP‐AES).
The Catalytic Versatility of Erythrocyte Carbonic Anhydrase. I. Kinetic Studies of the Enzyme-Catalyzed Hydration of Acetaldehyde<sup>*</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Catalytic Versatility of Erythrocyte Carbonic Anhydrase. I. Kinetic Studies of the Enzyme-Catalyzed Hydration of Acetaldehyde*Y. Pocker and J. E. MeanyCite this: Biochemistry 1965, 4, 11, 2535–2541Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://doi.org/10.1021/bi00887a037RIGHTS & PERMISSIONSArticle Views125Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (647 KB) Get e-Alerts Get e-Alerts
A Rice Calcium- and Calmodulin-Dependent Protein Kinase Restores Nodulation to a Legume Mutant (2006)

The Medicago truncatula DMI3 gene encodes a calcium- and calmodulin-dependent protein kinase (CCaMK) that is necessary for the establishment of both rhizobial and mycorrhizal symbioses. The two symbiotic signaling pathways diverge downstream of DMI3; therefore, it has been proposed that legumes have evolved a particular form of CCaMK, acting like a switch able both to discriminate between rhizobial and mycorrhizal calcium signatures and to trigger the appropriate downstream signaling pathway. To test this hypothesis, we examined whether a CCaMK gene from a nonlegume species was able to restore the rhizobial symbiotic properties of a M. truncatula dmi3 mutant. Our results show that a CCaMK gene from rice can restore nodule formation, indicating that CCaMKs from nonlegumes can interpret the calcium signature elicited by rhizobial Nod factors and activate the appropriate downstream target. The nodules did not contain bacteria, which suggests that DMI3 is also involved in the control of the infection process.
Atomic layer deposition of metal oxide thin films and nanostructures (2013)

Ankara : Materials Science and Nanotechnology Program of Graduate School of Engineering and Science of Bilkent University, 2013.
Immune responses to labial infection of BALB/c mice with herpes simplex virus type 1 (1981)

The kinetics of appearance of five humoral antibody responses (micro-neutralization assay [NT], complement fixation [CF], enzyme-linked immunosorbent assay [ELISA], radioimmunoassay [RIA], antibody-dependent cell-mediated cytotoxicity [ADCC]), were compared during labial infection of BALB/c mice with herpes simplex virus type 1 strain Patton. The ELISA/RIA antibody responses were present in most mice by day 5 after infection, at the beginning of the herpetic lip lesions; antibody effective in ADCC showed identical early kinetics. In contrast, NT/CF antibodies were not detected in most mice until day 10, at the time of resolution of the herpetic lip lesions. The humoral immune responses persisted for at least 6 months after infection. The NT and CF responses were closely correlated in time of appearance and titers (r = 0.9), as were the ELISA and RIA responses (r = 0.99). However, there was little correlation between NT/CF and ELISA/RIA responses (r = 0.02). The kinetics of the delayed type hypersensitivity response showed similar kinetics of appearance to the ELISA/RIA/ADCC humoral responses, and peaked similarly, but waned gradually over 2 months. The importance of antibody in protection against labial herpes simplex virus type 1 infection was demonstrated by the ability of passively transferred convalescent serum (that produced a minimum NT titer of 10 in recipient mice) to protect against development of herpetic lesions and death.
Building an integrated prosodic model of German (2001)

The intellegibility and naturalness of synthetic speech strongly depends on its prosodic quality. Departing from works by Mixdorff on a linguistically motivated model of German intonation based on the Fujisaki model, the current paper presents statistical results concerning the relationship between linguistic and phonetic information underlying an utterance and its prosodic features. Statistical analysis yields, inter alia, the following pairs of strongest single factor → prosodic feature: boundary depth (right) → syllable duration; boundary depth (left) → phrase command magnitude Ap; accent type (intoneme) → accent command amplitude Aa. These results were employed for training an FFNN-based integrated prosodic model predicting syllable durations along with syllable-aligned Fujisaki control parameters. Correlations between trained and predicted parameters suggest synergy effects, as they are higher for some parameters than correlations yielded when predicting parameters individually from the same set of input features using a regression model. Informal listening tests with first resynthesis examples showed encouraging results.
NEW SOFTWARE KICKS IN (1996)

RETURN TO ISSUEPREVNewsNEXTNEW SOFTWARE KICKS INWeb technology and drug discovery power fast-moving development efforts in computational chemistry softwareJAMES H. KRIEGERView Author Information C&EN WashingtonCite this: Chem. Eng. News 1996, 74, 38, 30–37Publication Date (Print):September 16, 1996Publication History Published online12 November 2010Published inissue 16 September 1996https://pubs.acs.org/doi/10.1021/cen-v074n038.p030https://doi.org/10.1021/cen-v074n038.p030newsACS PublicationsCopyright © 1996 AMERICAN CHEMICAL SOCIETYArticle Views9Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Computational chemistry,Software Get e-Alerts
Genetic analysis of barley mutants with modifications of powdery mildew resistance gene <i>Ml-a12</i> (1988)

Fifteen mutants with increased powdery mildew susceptibility (infection types between 0–1 and 3–4) were crossed with the Ml-a12 resistant mother line 'Sultan-5' (infection type 0) and the susceptible variety 'Carlsberg II'. Analysis of the material revealed that 13 mutants had mutational modifications of the Ml-a12 gene. Two mutants had a suppressor-mutant gene that modified the phenotypic expression of gene Ml-a12. One suppressor gene was recessive, the other was semidominant. The possible function of gene Ml-a12 is discussed.Key words: barley, Hordeum vulgare, powdery mildew, Erysiphe graminis hordei, mutation, resistance, suppressor.
USA po volbách v proudu změn (1992)

Karel Krátký, nar. 1930, vystudoval filozofickou fakultu Univerzity Karlovy. Pracoval ve Vojenském historickém ústavu, v Ústavu pro mezinárodní politiku a ekonomii a v Ústavu dějin střední a východní Evropy ČSAV. V letech 1972-1990 pracoval mimo svůj obor . V současnosti je samostatným vědeckým pracovníkem Ústavu mezinárodních vztahů. Zabývá se zejména problematikou vztahů USA a Evropy.
Formación en atención farmacéutica y seguimiento farmacoterapéutico coordinados por la Universidad de Costa Rica (2003)

Involved in the context of the pharmaceutical care the Faculty of Pharmacy at University of Costa Rica (UCR), has occurred to the task of pharmaceutical care were nowadays the transverse axis of this curriculum. The training function within the faculty has been in charge of the National Drug Information Center (CIMED), even for undergraduate or professionals..
Method: During 2002-2003 the CIMED has organized 2 courses on pharmacotherapy follow-up using the Dader methodology devoted to professionals, which have been attended by 94 professionals. A survey to the participants of both courses with a 5-point scale was made.
Results: 44 pharmacists in 2002 and 50 in the 2003 attended the courses. Those courses were very good considered in practically all the categories by most of the assistants. Altogether, of the 94 pharmacists there are 32 who have showed their interest in the Dader methodology and offer the service of pharmacotherapy follow-up to the patients with diverse pathologies.
Although the training courses are very important, it is also important to pursuit that participants keep on providing follow-up in the following weeks and months; otherwise, professionals lose the interest in caring the patient and the knowledge acquired on the methodology and the forms management are forgotten.
Parallel operation of inverters for distributed photovoltaic power supply system (2003)

This paper proposes a control technique for operating two or more single phase inverter modules in parallel with no auxiliary interconnections. In the proposed parallel inverter system, all of the modules have the same circuit configuration, and each module includes an inner current loop and an outer voltage loop controls. With power sharing control, load sharing can be automatically achieved and the output current of each inverter can be accurately limited to its maximum rating. This technique uses frequency and fundamental voltage droop to allow all independent inverters to share the load in proportion to their capacities. From the simulation and experiment results, the proposed control for PVS inverters is verified.
Turbulent heat flux measurements over the Greenland, Norwegian and Barents seas (1995)

Turbulent heat fluxes in the Greenland, Norwegian and Barents Seas during March 1988, February and March 1989, November 1991 and January and March 1992 have been calculated with the bulk method using shipboard-based measurements of wind speed, air and sea surface temperatures, relative humidity and atmospheric pressure. The largest mean total turbulent heat flux, near 250 W/m2, was in the Greenland Sea in March 1989. The Norwegian Sea had mean turbulent heat fluxes of 130 W/m2, whereas the Barents Sea had the smallest mean turbulent heat fluxes. These results compared satisfactorily with climatological studies of the region. However, this study shows the turbulent heat fluxes to be much smaller than those of a recent study, especially in the northern Greenland and Barents Seas. Additionally, comparison of turbulent heat flux values based on 10 minute averages with fluxes calculated from the averages of the bulk variables for an entire ship's cruise (10 - 22 days) shows the values to differ by only approx. 5%.
[Non-surgical method of treatment of dislocation of the acromial end of the clavicle]. (1978)

An apparatus for reposition and fixation of the clavicle in case of the dislocation, in the acromioclavicular joint is described. The method was used in the treatment of 60 patients. There were 57 good results, and in 3 cases the results were fair.
Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation? (2000)

In this study, we explored the relationship between regulation of surface mu-opioid receptor number, ligand-induced G protein activation (measured by [(35)]S]guanosine-5'-O-(3-thio)triphosphate (GTPgammaS) binding) and second messenger signaling (measured by the inhibition of cAMP accumulation). Etorphine and two isomers of cis-beta-hydroxy-3-methylfentanyl (RTI-1a and RTI-1b), which were full agonists for G protein activation and signaling, caused approximately a 50% loss of surface receptors after 1 h of treatment. Fentanyl and morphine were full agonists for inhibiting cAMP accumulation and partial agonists for stimulating [(35)S]GTPgammaS binding and internalization. Although both agonists were approximately 80% as efficacious as etorphine in stimulating [(35)S]GTPgammaS binding, fentanyl induced a 35% loss of surface receptors, whereas morphine only caused a 10% loss. Additionally, both long- and short-term treatment with the opioid antagonist naloxone caused increases in surface receptors. Unexpectedly, the weak partial agonists buprenorphine and one isomer of cis-beta-hydroxy-3-methylfentanyl (RTI-1d) also were found to cause an increase in surface receptors. Treatment with pertussis toxin (PTX) diminished agonist-induced loss of surface receptors. Furthermore, the abilities of morphine and fentanyl to cause internalization were more impaired after PTX treatment than that of etorphine. PTX treatment also significantly enhanced the increase in surface receptor number caused by 18-h treatment with naloxone and buprenorphine. The results of this study suggest that disruption of G protein coupling by PTX treatment affects ligand-regulated mu-receptor trafficking and that partial agonists for signaling can vary greatly in the ability to regulate the number of surface mu-opioid receptors.
Can ESP be tested by EGP (2003)

Background: There are two main methods employed for the evaluation of the reading comprehension ability of students of ESP; one using specialized English texts, and the other with general English texts. Purpose: To determine whether or not there is a correlation between the two methods. Methods: In the regular 1998 examinations for admission to PhD courses for 18 different medical disciplines, in which 30 subject-specific English test items were given to the applicants of each discipline, all of them were also evaluated using a set of 30 general English test items (n=201 0). Results: There was a positive correlation of71% between the scores of the examinees in the two tests, the highest and the lowest correlation being respectively in the scores of the applicants of Epidemiology (84%; n=118), and environmental health (56%; n=70). Conclusion: Our finding seems to warrant the use of EGP test as an adequate measure of English language competency for academic purposes. Keywords: LANGUAGE TESTING, READING COMPREHENSIONASSESSMENT, EGP, ESP
Monitoring the effect of magnetically aligned collagen scaffolds on tendon tissue engineering by PSOCT (2009)

As the repair of injured or degenerated tendon is often compromised by the shortage of suitable donor tissue, other procedures need to be developed. The application of a functional tissue engineered tendon could prove to be a promising alternative therapy. Due to their good biocompatibility, collagen hydrogel based scaffolds have been considered to be potentially suitable for engineering tendon tissue in vitro. One of the major limitations of collagen hydrogels for engineering tissues is the difficulty in controlling their architecture and collagen concentration which results in poor mechanical strength. This study aims to overcome these limitations by creating a highly biocompatible scaffold that is both mechanically robust and aligned. Collagen fibers were pre-aligned under a high magnetic field then concentrated using plastic compression. Primary tenocytes cultured from rats were seeded on the aligned scaffolds. Following a protocol in public domain, thick cultured collagen constructs were rolled up into a spiral after undergoing plastic compressed. Both a light microscopy and a polarization sensitive optical coherence tomography (PSOCT) with central beam at 1300 nm were used to monitor the birefringence in the constructs. Conventional light microscopy showed that the tenocytes aligned along the pre-organized collagen bundles in contrast to the random distributed observed on unaligned scaffolds. PSOCT only revealed weak birefringence from aligned but uncompressed constructs. However, PSOCT images showed contrast band structures in the spiral constructs which suggests that the birefringence signal depends on the density of aligned collagen fibers. The effect of aligned cells, neo-formed matrix and the plastic compression on the birefringence signals are discussed in this paper briefly.