gebhart/patrepeval huggingface dataset:
Self-Aggregation of Spin-Labeled Alamethicin in ePC Vesicles Studied by Pulsed Electron−Electron Double Resonance (2007)

The pulsed electron−electron double resonance technique was used to study the dipole−dipole interactions between 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid spin labels located at position 16 of an alamethicin analogue in ePC vesicles that were frozen to 77 K. We show that under these conditions the alamethicin molecules tend to form aggregates over the range of peptide concentrations 3.5 × 10-3 to 1 × 10-2 M. The number of molecules in the aggregate is found to be 4.2 ± 0.2. A spin-label distance distribution function is also obtained with a maximum at a distance of 2.3 nm and a half-height width of 1.3 nm. We envisage that these data will permit us to generate a molecular model of cellular ion channels
A Plasminogen Activator Inhibitor-1 Inhibitor Reduces Airway Remodeling in a Murine Model of Chronic Asthma (2012)

We previously reported that plasminogen activator inhibitor (PAI)-1 deficiency prevents collagen deposition in the airways of ovalbumin (OVA)-challenged mice. In this study, we explored the therapeutic utility of blocking PAI-1 in preventing airway remodeling, using a specific PAI-1 inhibitor, tiplaxtinin. C57BL/6J mice were immunized with intraperitoneal injections of OVA on Days 0, 3, and 6. Starting on Day 11, mice were challenged with phosphate-buffered saline or OVA by nebulization three times per week for 4 weeks. Tiplaxtinin was mixed with chow and administered orally from 1 day before the phosphate-buffered saline or OVA challenge. Lung tissues were harvested after challenge and characterized histologically for infiltrating inflammatory cells, mucus-secreting goblet cells, and collagen deposition. Airway hyperresponsiveness was measured using whole-body plethysmography. Tiplaxtinin treatment significantly decreased levels of PAI-1 activity in bronchoalveolar lavage fluids, which indicates successful blockage of PAI-1 activity in the airways. The number of infiltrated inflammatory cells was reduced by tiplaxtinin treatment in the lungs of the OVA-challenged mice. Furthermore, oral administration of tiplaxtinin significantly attenuated the degree of goblet cell hyperplasia and collagen deposition in the airways of the OVA-challenged mice, and methacholine-induced airway hyperresponsiveness was effectively reduced by tiplaxtinin in these animals. This study supports our previous findings that PAI-1 promotes airway remodeling in a murine model of chronic asthma, and suggests that PAI-1 may be a novel target of treatment of airway remodeling in asthma.
Magnetic bistability and memory of conduction electrons released from oxygen vacancies in gallium oxide (1995)

Abstract Conduction electrons released from oxygen vacancies in gallium oxide exhibit an electron spin resonance (CESR) line with pronounced hysteresis when the magnetic field is swept upward and backward. This memory effect is due to the existence of a bistable nuclear field induced by dynamic nuclear polarization of gallium nuclei. It is shown that this bistability is the consequence of the one-dimensional (1D) character of the band structure of gallium oxide, with the conduction band formed almost exclusively from 4s orbitals of gallium in octahedral sites, forming isolated double chains aligned along the b-axis.
cAAC‐Stabilized 9,10‐diboraanthracenes—Acenes with Open‐Shell Singlet Biradical Ground States (2020)

Narrow HOMO-LUMO gaps and high charge-carrier mobilities make larger acenes potentially high-efficient materials for organic electronic applications. The performance of such molecules was shown to significantly increase with increasing number of fused benzene rings. Bulk quantities, however, can only be obtained reliably for acenes up to heptacene. Theoretically, (oligo)acenes and (poly)acenes are predicted to have open-shell singlet biradical and polyradical ground states, respectively, for which experimental evidence is still scarce. We have now been able to dramatically lower the HOMO-LUMO gap of acenes without the necessity of unfavorable elongation of their conjugated π system, by incorporating two boron atoms into the anthracene skeleton. Stabilizing the boron centers with cyclic (alkyl)(amino)carbenes gives neutral 9,10-diboraanthracenes, which are shown to feature disjointed, open-shell singlet biradical ground states.
Emerging physics for a breakthrough thin-film electrolytic cell power unit (1999)

Electrolytic cell experiments are described using cathodes coated with thin metallic films (order of 500 Å, using variously Ni, Pd and Ti) in a flowing packed-bed electrolytic cell producing ∼1 W/cc excess power. Measurements of nuclear isotopes produced in the films suggest a nuclear reaction origin for the heat. The characteristic “signatures” of the isotope array observed in these experiments are discussed, along with speculations about the reaction physics involved.
Oxydativer Abbau von Uronsäuren und Derivate der Trioxyglutarsäuren (1952)

Abstract Die Identifizierung von Aldo‐hexuronsäuren anhand von Trioxyglutar‐ und Zucker‐ bzw. Schleimsäuren wird ausführlich diskutiert.
Synthesis of Novel Tricyclic Isoindole Derivatives. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Angiotensin I, II, and III in sheep. A model of angiotensin production and metabolism. (1981)

The arterial and central venous concentrations of angiotensin I (AI), Val5-angiotensin II ([Val5]AII), and Val5-angiotensin III ([Val5]AIII(2-8)) were quantitatively determined in conscious sheep before and after sodium depletion. All three angiotensins were elevated in blood with progressive sodium loss. During sodium deficiency the arteriovenous concentration ratios (A:V) of AI, [Val5]AII, and [Val5]AIII(2-8) were found to be 0.48 +/- 0.03 (n = 9), 1.30 +/- 0.05 (n = 16), and 1.52 +/- 0.05 (n = 11) respectively. Intravenous infusion of [Val5]AII or [Val5]AIII(2-8) significantly elevated the A:V of respective angiotensins, being 2.09 +/- 0.28 (n = 5) for [Val5]AII and 2.2 +/- 0.37 (n = 6) for [Val5]AIII(2-8). The blood clearance rates of exogenous [Val5]AII and [Val5]AIII(2-8) in sodium-depleted sheep were calculated to be 135 +/- 15 liter/hr (n = 10) and 140 +/- 13 liter/hr (n = 10) respectively. Based on these experimental data, a steady-state model of angiotensin metabolism was constructed. If it is assumed that endogenous arterial blood [Val5]AII and [Val5]AIII(2-8) cleared metabolically at a similar rate as exogenous arterial blood angiotensins, it can be calculated that at steady-state 55% of the arterial [Val5]AII concentration was derived from the peripheral vascular bed. For [Val5]AIII(2-8), 63% of the arterial concentration was derived from the pulmonary circulation. The concentration of [Val5]AIII(2-8) in arterial blood was 42% of [Val5]AII.
Robust path tracking control with autonomous consideration of torque saturation (2002)

Summary form only given. The paper proposes the new autonomous adjusting algorithms for the saturation of joint torque and controller output. The proposed algorithms are two online autonomous algorithms. The first algorithm adjusts the acceleration torque in joint space in order for torque saturation to to have no effect. The proposed algorithm adjusts the acceleration torque which is based on the acceptable ratio of acceleration torque current. The compensatory torque current for disturbance torque is obtained from the estimated value of the disturbance observer in joint space. The proposed algorithm always maintains the original direction of the total acceleration torque, and only reduces its amplitude. The second algorithm adjusts the reference of a path tracking control system in Cartesian space, and it considers the saturation of the path tracking control in joint space and Cartesian space. The robust path tracking control method using the proposed algorithms well realizes the accurate path tracking response robustly, and it has no torque saturation effect.
Pharmacokinetics of Folates in the Rat and Man (1974)

Conference Abstract| November 01 1974 Pharmacokinetics of Folates in the Rat and Man J. A. Blair; J. A. Blair 1Department of Chemistry, University of Aston in Birmingham2General Hospital, Birmingham Search for other works by this author on: This Site PubMed Google Scholar J. R. G. Beavon; J. R. G. Beavon 1Department of Chemistry, University of Aston in Birmingham2General Hospital, Birmingham Search for other works by this author on: This Site PubMed Google Scholar E. Dransfield; E. Dransfield 1Department of Chemistry, University of Aston in Birmingham2General Hospital, Birmingham Search for other works by this author on: This Site PubMed Google Scholar R. J. Leeming; R. J. Leeming 1Department of Chemistry, University of Aston in Birmingham2General Hospital, Birmingham Search for other works by this author on: This Site PubMed Google Scholar K. Ratanasthien; K. Ratanasthien 1Department of Chemistry, University of Aston in Birmingham2General Hospital, Birmingham Search for other works by this author on: This Site PubMed Google Scholar F. J. Staff; F. J. Staff 1Department of Chemistry, University of Aston in Birmingham2General Hospital, Birmingham Search for other works by this author on: This Site PubMed Google Scholar W. T. Cooke W. T. Cooke 1Department of Chemistry, University of Aston in Birmingham2General Hospital, Birmingham Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd © 1974 The Biochemical Society and the Medical Research Society1974 Clin Sci Mol Med (1974) 47 (5): 21P. https://doi.org/10.1042/cs047021Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation J. A. Blair, J. R. G. Beavon, E. Dransfield, R. J. Leeming, K. Ratanasthien, F. J. Staff, W. T. Cooke; Pharmacokinetics of Folates in the Rat and Man. Clin Sci Mol Med 1 November 1974; 47 (5): 21P. doi: https://doi.org/10.1042/cs047021Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1974 The Biochemical Society and the Medical Research Society1974 Article PDF first page preview Close Modal You do not currently have access to this content.
Diffusivity and Viscosity of Concentrated Hydrogenated Polybutadiene Solutions (2000)

We report measurements of diffusion (D) and viscosity (η) in hydrogenated polybutadiene (hPB)/alkane solutions. The volume fractions (φ) extend from 0.20 up to the melt and the molecular weights (M) from 4900 up to 440 000; the number of entanglements per chain, M/Me, ranges up to about 450. The temperature dependences of both D and η are similar, consistent with literature values, and independent of φ and M. We thus conclude that the monomeric friction factor is also independent of φ and M. For all samples with M/Me ≥ 3 the data are consistent with the scaling relations D ∼ M-2.4±0.1φ-1.8±0.2 and η ∼ M3.4±0.1φ3.8±0.2; within the precision of the data the M exponents do not depend on φ, and the φ exponents do not depend on M. The M exponent for D in solution is consistent with previously reported studies for φ ≤ 0.4 but apparently conflicts with the reptation value of −2.0 in the melt. However, by comparing with the literature melt self-diffusion data for hPB and six other polymers, it is clear that the exponent is, in fact, universally stronger than −2.0. Furthermore, if a single universal exponent is assumed, the best value based on all the data is −2.28 ± 0.05. Our hPB data resolve the longstanding anomaly that the longest relaxation times τ1 based on translation (∼Rg2/D) and orientational relaxation (∼η) appeared to have different M dependences. The data also indicate that for both solutions and melts the dynamics are determined primarily by the number of entanglements per chain. The data are compared with current models of polymer dynamics, both reptative and nonreptative. In the former case it is clear that a self-consistent theory incorporating both "constraint release" and "contour length fluctuations" is required.
Nuclear magnetic resonance study of the topography of binding sites of Escherichia coli carbamoyl-phosphate synthetase (1983)

Two paramagnetic probes, viz., Mn2+ and Cr3+-ATP, were used to map distances to various loci on carbamoyl-phosphate synthetase by using NMR measurements. The paramagnetic influence of Mn2+ on the 1H of L-glutamate and L-ornithine was measured at 200 and 360 MHz. On the basis of these data, a correlation time for the paramagnetic interaction was determined (2 X 10(-9) s) and used to compute distances. These were in the range 7-9 A. Distances were also calculated from Mn2+ to the 13C-5 atom of glutamate (8.6 A), to the monovalent cation site (approximately 8 A), and to the phosphorus atoms of ATP in the Co(NH3)4ATP complex. For studies of the monovalent cation site relaxation rates of 6Li+, 7Li+, and 15NH4+ were measured. With Cr3+ ATP as a paramagnetic substrate analogue, Cr3+ to 13C distances were measured with the substrates HCO3(-) and [5-13C]glutamate. These NMR data provide the first topographical map of the arrangement of substrates, metal ion activators, and allosteric modifiers on the Escherichia coli carbamoyl-phosphate synthetase dimer.
Interlayer coupling in ferromagnetic epitaxial Fe3Si∕FeSi2 superlattices (2006)

Ferromagnetic epitaxial B2-type Fe3Si∕FeSi2 superlattices were prepared on Si(111) at room temperature by facing target direct-current sputtering. The bilinear and biquadratic coupling constants J1 and J2 of the antiferromagnetically coupled superlattice were comparable to those of the similar superlattices using Fe layers although the saturation magnetization of Fe3Si is approximately half as large as that of Fe. The authors believe that this is due to the formation of a well-ordered quantum well in the spacers, which is mainly caused by the regular accumulation of highly oriented Fe3Si layers.
7,8‐Dihydropyrido[2,3‐d]pyrimidin‐2‐one; a Bicyclic Cytosine Analogue Capable of Enhanced Stabilization of DNA Duplexes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of Dipivaloylmethane (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of DipivaloylmethaneKarl R. Kopecky, Derek Nonhebel, Gene Morris, and George S. HammondCite this: J. Org. Chem. 1962, 27, 3, 1036–1037Publication Date (Print):March 1, 1962Publication History Published online1 May 2002Published inissue 1 March 1962https://pubs.acs.org/doi/10.1021/jo01050a506https://doi.org/10.1021/jo01050a506research-articleACS PublicationsRequest reuse permissionsArticle Views460Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy (2004)

MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.
Active holographic spectral equalization and channel management for WDM (2002)

In this paper, we present a new technique for active management of the gain, based on a polarization-insensitive diffractive ferroelectric liquid crystal (FLC) in-line optical filter. The technique is scaleable to tens of channels and is potentially low-cost in volume production.
High-level verification of system designs (2009)

The parietal cortex has been widely implicated in the processing of depth perception by many neuroimaging studies, yet functional near infrared spectroscopy (fNIRS) has been an under-utilised tool to examine the relationship of oxy- ([HbO]) and de-oxyhaemoglobin ([HbR]) in perception. Here we examine the haemodynamic response (HDR) to the processing of induced depth stimulation using dynamic random-dot-stereograms (RDS). We used fNIRS to measure the HDR associated with depth perception in healthy young adults (n = 13, mean age 24). Using a blocked design, absolute values of [HbO] and [HbR] were recorded across parieto-occipital and occipital cortices, in response to dynamic RDS. Control and test images were identical except for the horizontal shift in pixels in the RDS that resulted in binocular disparity and induced the percept of a 3D sine wave that 'popped out' of the test stimulus. The control stimulus had zero disparity and induced a 'flat' percept. All participants had stereoacuity within normal clinical limits and successfully perceived the depth in the dynamic RDS. Results showed a significant effect of this complex visual stimulation in the right parieto-occipital cortex (p < 0.01, η(2) = 0.54). The test stimulus elicited a significant increase in [HbO] during depth perception compared to the control image (p < 0.001, 99.99 % CI [0.008-0.294]). The similarity between the two stimuli may have resulted in the HDR of the occipital cortex showing no significant increase or decrease of cerebral oxygenation levels during depth stimulation. Cerebral oxygenation measures of [HbO] confirmed the strong association of the right parieto-occipital cortex with processing depth perception. Our study demonstrates the validity of fNIRS to investigate [HbO] and [HbR] during high-level visual processing of complex stimuli.
Ultralong Dephasing Time in InGaAs Quantum Dots (2001)

We measure a dephasing time of several hundred picoseconds at low temperature in the ground-state transition of strongly confined InGaAs quantum dots, using a highly sensitive four-wave mixing technique. Between 7 and 100 K the polarization decay has two distinct components resulting in a non-Lorentzian line shape with a lifetime-limited zero-phonon line and a broadband from elastic exciton-acoustic phonon interactions.
The New Interpretation of Quantum Mechanics and Hidden Parameters (2001)

The new interpretation of Quantum Mechanics is based on a complex probability theory. An interpretation postulate specifies events which can be observed and it follows that the complex probability of such event is, in fact, a real positive number. The two-slit experiment, the mathematical formulation of the complex probability theory, the density matrix, Born's law and a possibility of hidden variables are discussed.
Distributed Computing Column 77 Consensus Dynamics (2020)

Overview. In this edition of the column, we have an exciting contribution from Luca Becchetti, Andrea Clementi, and Emanuele Natale, who provide an in-depth algorithmic perspective on emergent complexity. Roughly, this area aims to characterize non-trivial emergent properties of complex systems, composed of large numbers of relatively simple agents, which can cooperate to express complex global behaviours. Interestingly, over the past two decades, fundamental processes such as consensus or opinion-formation dynamics have been studied independently by different research communities: for instance, in the Distributed Computing community, these dynamics have been studied in the context of population protocols via discrete-time analysis, whereas, in the Control and Optimization community, similar (or even identical) dynamics have been analyzed via continuous-time processes. One very useful feature in this column's contribution is the fact that it provides a unified view of these results, along with the mathematical background to understand and differentiate the underlying results.
Influence of structure on the optical limiting properties of nanotubes (2005)

We investigate the role of carbon nanotubes structure on their optical limiting properties. Samples of different and well-characterized structural features are studied by optical limiting and pump-probe experiments. The influence of the diameter's size on the nano-object is demonstrated. Indeed, both nucleation and growth of gas bubbles are expected to be sensitive to diameter.
Inhibition of “Serine” Esterases by Phenylarsonic Acids (1968)

Abstract Chymotrypsin, trypsin, and Novo and Carlsberg subtilisins undergo a reversible, time-dependent inhibition by phenylarsonates. The inhibition of these enzymes by p-nitro-, p-tolyl-, p-aminophenyl-, and phenylarsonate was studied in detail, as a function of pH and inhibitor concentration, by a variety of approaches. Ki values were determined for the inhibition of chymotrypsin and the subtilisins by these compounds. Active site titrations and dye displacement experiments were used to show that the inhibition results from the interaction of the arsenicals with the active sites of these enzymes. The pH dependence of the inhibition of both chymotrypsin and the subtilisins followed the theoretical curve for the protonation of a group on the enzymes with a pK' value of 7.15. The results obtained in this study, taken in conjunction with earlier scattered reports in the literature, suggest that the phenylarsonates are general inhibitors of serine esterases. Possible mechanisms for such inhibition are discussed.
Phenotypic and Functional Comparison of Mesenchymal Stem Cells Derived from the Bone Marrow of Normal Adults and Patients with Hematologic Malignant Diseases (2007)

Mesenchymal stem cells (MSCs) have received much attention for their ability to differentiate into various cell types under specific conditions and to support the proliferation of hematopoietic stem cells. However, it is unclear whether the characteristics of MSCs are altered in different disease states. In this study, we obtained and expanded MSCs from bone marrow of patients with acute lymphoblastic leukemia (ALL), Hodgkin disease (HD), and non-Hodgkin lymphoma (NHL). Our results showed that MSCs derived from ALL, HD, and NHL were similar to normal adult bone marrow-derived MSCs in morphology, growth properties, surface epitopes, and differentiation ability in vitro. Moreover, MSCs derived from ALL, NHL, and HD had a normal karyotype and ultrastructure. These cells could express hematopoietic cytokines and support hematopoiesis in long-term culture. However, adherent cells isolated from bone marrow of patients with acute myeloid leukemia (AML) showed abnormal biological properties, including heterogeneity in morphology, limited proliferation capacity, and impaired differentiation and hematopoiesis support ability. These results indicate that there are differences in the characteristics of adherent cells derived from different disease states, which may be important for reasonable MSC selection in stem cell-based therapy.