gebhart/patrepeval huggingface dataset:
Human Neural Stem Cells Encoding ChAT Gene Restore Cognitive Function via Acetylcholine Synthesis, Aβ Elimination, and Neuroregeneration in APPswe/PS1dE9 Mice (2020)

In Alzheimer disease (AD) patients, degeneration of the cholinergic system utilizing acetylcholine for memory acquisition is observed. Since AD therapy using acetylcholinesterase (AChE) inhibitors are only palliative for memory deficits without slowing or reversing disease progress, there is a need for effective therapies, and stem cell-based therapeutic approaches targeting AD should fulfill this requirement. We established a human neural stem cell (NSC) line encoding choline acetyltransferase (ChAT) gene, an acetylcholine-synthesizing enzyme. APPswe/PS1dE9 AD model mice transplanted with the F3.ChAT NSCs exhibited improved cognitive function and physical activity. Transplanted F3.ChAT NSCs in the AD mice differentiated into neurons and astrocytes, produced ChAT protein, increased the ACh level, and improved the learning and memory function. F3.ChAT cell transplantation reduced Aβ deposits by recovering microglial function; i.e., the down-regulation of β-secretase and inflammatory cytokines and up-regulation of Aβ-degrading enzyme neprilysin. F3.ChAT cells restored growth factors (GFs) and neurotrophic factors (NFs), and they induced the proliferation of NSCs in the host brain. These findings indicate that NSCs overexpressing ChAT can ameliorate complex cognitive and physical deficits of AD animals by releasing ACh, reducing Aβ deposit, and promoting neuroregeneration by the production of GFs/NFs. It is suggested that NSCs overexpressing ChAT could be a candidate for cell therapy in advanced AD therapy.
General Solution Growth of Mesoporous NiCo<sub>2</sub>O<sub>4</sub> Nanosheets on Various Conductive Substrates as High‐Performance Electrodes for Supercapacitors (Adv. Mater. 7/2013) (2013)

Interconnected mesoporous NiCo2O4 nanosheets can be directly grown on various conductive substrates including Ni foam, stainless steel, Ti foil, and flexible graphite paper through a simple solution method. The NiCo2O4 nanosheets-Ni foam structure exhibits superior pseudocapacitive performance with a high capacitance of 1743 F g−1 under a constant current density of 7.08 A g−1 and a capacitance loss of only 6.7% after 3000 cycles. More details can be found in the article by Xiong Wen (David) Lou and Genqiang Zhang on page 976.
Defining and implementing a distributed and reconfigurable information system for prognostics A real world integrated predictive maintenance syst em (2011)

Abstract  According to Condition Based Maintenance practitioners, various activities, ranging from dat a collection through the recommendation of specific maintenance actions, must be carried out to perform predictive maintenan ce. Nevertheless, in practice, (and in spite of recomme ndations like those ones of the OSA-CBM standard), defining and implementing a computer software system for CBM is not a trivial task. That can be mostly explained by the ne cessity of providing a distributed application that enables to share data and information in an easy but effective manner in-betw een various actors from various industrial plants. Following th at, the aim of the paper is to describe a collaborative software t hat has been developed in the society e-m@systec. Its simple arc hitecture, as well as its evolving and customizable capabilities make the global information system as useful for distributed applic ations. The usage of JEE technology improves the portability of t he system. This software is well adapted to support predictive maintenance strategies. Thereby and as for an illustration, an e xample related to a prognostic problem is also described. Predictive maintenance; CBM; e-maintenance platform; modular architecture; prognotic module
No Association Between Risk of Anterior Cruciate Ligament Rupture and Selected Candidate Collagen Gene Variants in Female Elite Athletes From High-Risk Team Sports (2018)

Background: Several single-nucleotide variants (SNVs) in collagen genes have been reported as predisposing factors for anterior cruciate ligament (ACL) tears. However, the evidence is conflicting and does not support a clear association between genetic variants and risk of ACL ruptures. Purpose: To assess the association of previously identified candidate SNVs in genes encoding for collagen and the risk of ACL injury in a population of elite female athletes from high-risk team sports. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 851 female Norwegian and Finnish elite athletes from team sports were included from 2007 to 2011. ACL injuries acquired before inclusion in the cohort were registered by interview. The participants were followed prospectively through 2015 to record new complete ACL injuries. Six selected SNVs were genotyped ( COL1A1: rs1800012, rs1107946; COL3A1: rs1800255; COL5A1: rs12722, rs13946; COL12A1: rs970547). Results: No associations were found between ACL rupture and the SNVs tested. Conclusion: The study does not support a role of the 6 selected SNVs in genes encoding for collagen proteins as risk factors for ACL injury. Clinical Relevance: Genetic profiling to identify athletes at high risk for ACL rupture is not yet feasible.
Coexpression in humans by kidney and fetal envelopes of a 280 kDa-coated pit-restricted protein. Similarity with the murine target of teratogenic antibodies. (1992)

Experimental studies performed in the rat over the last three decades have shown that antibodies raised against kidney or yolk sac, which, in the rat, surrounds the embryo and serves as a placenta during the major part of pregnancy, induced fetal resorptions or malformations. It is generally considered that the teratogenic antibodies decrease internalization and degradation of maternal proteins by yolk sac epithelial cells leading to an inadequate supply of nutriments to the embryo. These observations demonstrating the pathogenic role of antibodies to fetal envelopes are of great potential interest in clinical pathology since most cases of fetal malformations in humans are of unknown cause. The authors have recently shown that the key teratogenic antibodies in the murine system were directed against a 280 kDa-coated pit protein (gp280) specific for the brush border of epithelial cells lining the renal proximal tubule and the yolk sac. This observation allows for the unique opportunity to search for a similar system in humans. In this study, the presence in humans of a protein closely related to murine gp280 is shown, as indicated by extensive immunologic crossreactivity, close apparent molecular weights, strong homology of bidimensional peptide maps, and restricted distribution at the organ and subcellular level. In addition to kidney and yolk sac, human gp280 was also detected within the coated pits of the placental syncytiotrophoblastic cells. When introduced in an in vitro rat embryo culture system, antibodies to human gp280-induced developmental anomalies in a dose-dependent manner. These observations indicate that the antigenic component of the murine model is present in humans and can give rise to heterologous antibodies that cause developmental anomalies, suggesting that the experimental model might be of significance in human pathology.
Mineralization of Atrazine during Composting with Untreated and Pretreated Lignocellulosic Substrates (1995)

Composting offers a relatively inexpensive and environmentally safe method for the potential bioremediation of pesticide-laden rinsewater. The purpose of this study was to evaluate whether degradation and mineralization of atrazine, a pesticide used extensively in the U.S., can be enhanced during composting with pretreated lignocellulosic materials. Wood that was subjected to steam explosion (STEX wood) or ammonia explosion (AFEX wood), untreated wood (native), and shredded newspaper were selected as the composting substrates. These substrates which differed in composition as determined by the quantitative saccharification and enzymatic hydrolysis techniques, were amended with [U-ring-14C]Atrazine (500 ppm, 5.6.μCi per composter) and composted in two-liter lab-scale composters. The results showed that the highest rate and extent of total organic matter mineralization to CO2 was observed with AFEX wood as the substrate, but atrazine mineralization was relatively higher (11 percent) with paper as the substrate. There was no significant enhancement in atrazine mineralization when composted with the pretreated woods (AFEX wood and STEX wood) as compared to that observed with the native wood.
Quantitative DNA Methylation Profiling on a High-Density Oligonucleotide Microarray (2009)

Recently, the analysis and functional elucidation of CpG island methylation has become a focus area of genomic research. Deviations from the normal parental imprinting pattern have been shown to cause developmental defects associated with serious symptoms. Aberrant DNA methylation of tumor suppressor and other functional genes, especially when found in 5' untranslated regions and early exons, has been associated with tumorigenesis. In the context of applying DNA methylation analysis for the molecular characterization of cancer and other diseases, standardized protocols enabling parallel genome-wide methylation profiling of numerous samples are required. DNA methylation profiling is described using a CpG island microarray representing more than 50,000 CpG-rich DNA fragments. Fragments were selected to represent the vast majority of known 5'-untranslated regions as well as the first exons of thousands of genes. Measurement probes were designed to represent these fragments were displayed on an Affymetrix custom array. A modified procedure for differential methylation hybridization (DMH) is described for methylation enrichment. Application of a novel signal normalization concept enables accurate and reproducible measurements using a single fluorescence channel. The use of defined calibrator material allows quantification of DNA methylation patterns by DMH in a massively parallel fashion.
Oil shale project run summary large retort Run L-2. [Oil shale blocks in shale nibble matrix] (1981)

The object of the L-2 Run was to determine the retorting behavior of individual oil shale blocks in a shale rubble matrix during simulated modified in-situ (MIS) combustion retorting. Conclusions are as follows: The interiors of large particles are delayed in retorting (compared to a surrounding matrix of small particles) by the greater lengths of the heat transports paths in the larger particles and their lower surface/mass ratio. In Run L-2 these delays were determined for six cylindrical blocks of three sizes surrounded by two different matrices. The delays resulted in oil being released from the blocks into an oil degrading environment in the rubble matrix. The combination of high interior block and matrix temperatures and oxygen presence at block surfaces during oil release caused the oil produced in block interiors to be degraded either in transport from the block interiors or in the rubble matrix. For three of the blocks, the fraction of generated oil that was degraded to light (C/sub 1/-C/sub 4/) hydrocarbons was determined from analysis of retort offgas produced during block retorting. The offgas ethene/ethane ratio was a sensitive indicator of oil degradation for all the blocks. High ethene/ethane ratios of intra of intra-retort gas sampledmore » near the blocks the correlated with oxygen presence. The ethene/ethane ratios increased with both block size and matrix heating rate. This last factor was influenced by matrix size distribution, the bulk heating rate tending to be lower for the broader size range material.« less
Impaired osmoregulation at high altitude. Studies on Mt Everest. (1984)

Osmoregulation was studied in 13 mountaineers who had experienced long-term exposure to high altitude on Mt Everest. Serum osmolality rose from 290 +/- 1 mOsm/kg to 295 +/- 2 mOsm/kg at 5,400 m and finally to 302 +/- 4 mOsm/kg at 6,300 m after a mean of 26.5 days above 5,400 m. Despite this degree of osmoconcentration, plasma arginine-vasopressin concentration remained unchanged: 1.1 +/-0.1 microU/mL at sea level, 0.8 +/- 0.1 microU/mL at 5,400 m, and 0.9 +/- 0.1 microU/mL at 6,300 m. Urinary vasopressin excretion was also similar at all three altitudes. We conclude that prolonged exposure to high altitude may result in persistent impairment of osmoregulation, caused in part by an inappropriate arginine-vasopressin response to hyperosmolality.
Probing ergot alkaloid biosynthesis: synthesis and feeding of a proposed intermediate along the biosynthetic pathway. A new amidomalonate for tryptophan elaboration (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProbing ergot alkaloid biosynthesis: synthesis and feeding of a proposed intermediate along the biosynthetic pathway. A new amidomalonate for tryptophan elaborationAlan P. Kozikowski, Makoto Okita, Motomasa Kobayashi, and Heinz G. FlossCite this: J. Org. Chem. 1988, 53, 4, 863–869Publication Date (Print):February 1, 1988Publication History Published online1 May 2002Published inissue 1 February 1988https://pubs.acs.org/doi/10.1021/jo00239a034https://doi.org/10.1021/jo00239a034research-articleACS PublicationsRequest reuse permissionsArticle Views870Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Maggot therapy for the treatment of intractable wounds (1999)

Maggot therapy is a relatively rapid and effective treatment, particularly in large necrotic wounds requiring debridement and resistant to conventional treatment and conservative surgical intervention.
Synthesis of Novel α‐Arylpropionic Acids and Their Derivatives. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sub-fluorinated Carbon Fluoride Cathode Materials for Primary Lithium Batteries (Review) (2010)

Abstract not Available.
Determination of Sulfonyl Urea Herbicides by Capillary Electrochromatography (1999)

Thirteen compounds are investigated using a commercially available CE system and capillary columns packed with 3-µm porous octadecylbonded silica. The detector response is very linear from 1–100 ppm with a correlation coefficient r2 of 1–0.990 for each compound. This paper is believed to be the first application using CEC for the determination of sulfonyl urea herbicides and the first reported use of hydrodynamic injection in CEC with packed columns and a commercial CE instrument.
STEROIDS AND RELATED NATURAL PRODUCTS: XXVIII. STEREOCHEMISTRY OF 3-HYDROXY-4-OXA-5α-CHOLESTANE AND RELATED HEMIACETALS (1966)

Several new 3-hydroxy-4-oxa type steroidal hemiacetals (V and VII) have been prepared by diborane reduction of the corresponding δ-lactones. A detailed proton magnetic resonance study of the hemiacetal (IXa) derived from 3-oxo-4-oxa-5α-cholestane (VIII) indicated that diborane reduction led in each case to an epimeric mixture. Treating hemiacetal IXa with methanol – hydrochloric acid gave a mixture of acetals IXb and IXc. Pure specimens of the epimeric acetals were obtained by preparative thin-layer chromatography, and configurational assignments based on proton magnetic resonance studies were provided for each isomer. Allowing lactone VIII (in tetrahydrofuran solution) to react with 1 equivalent of diborane during 4 min resulted in approximately 80% conversion into hemiacetal IXa, and provided an illustration of the potential utility of the reduction reaction.
Antennes multi-bandes pour application GPS/Galileo/TéléMesure MicroSat (2007)

Deux nouvelles topologies d'antennes multi-bandes a polarisation circulaire sont proposees pour le nouveau systeme europeen de navigation satellitaire Galileo. La premiere configuration est a base d'elements filaires tandis que la seconde est formee de triangles de Sierpinski. La conception et la simulation de ces deux structures ont ete elaborees a l'aide d'un outil approprie utilisant la methode des moments (MoM). Le comportement multi-bande de ces antennes est obtenu a l'aide de trappes. Ces dernieres peuvent etre concues soit en elements localises (capacites et inductances CMS) soit avec des elements distribues (lignes, stubs,...). Les deux antennes, et particulierement celle a base de triangles de Sierpinski, presentent de tres bonnes performances en termes d'adaptation, de bandes passantes et de polarisation circulaire. Les performances en rayonnement sont egalement satisfaisantes pour les deux structures et peuvent etre ameliorees en exploitant l'axe perpendiculaire a l'antenne. Enfin, les deux configurations d'antennes multi-bandes proposees offrent l'avantage d'etre flexibles, c'est a dire que le concept peut etre facilement adapte a d'autres applications.
Metabolic pathway analysis of glycerol metabolism in <i>Klebsiella pneumoniae</i> incorporating oxygen regulatory system (2009)

It is well known that environmental and genetic perturbations have major effects on the metabolic behavior of cells. In this work, a model that utilizes existing knowledge of oxygen and redox sensing/regulatory system to assist elementary flux modes (EFMs) has been developed and was carried out to predict the metabolic potential of Klebsiella pneumoniae for the production of 1,3-propanediol (1,3-PD) under anaerobic and aerobic conditions. It was found that the theoretical optimal 1,3-PD yield could reach to 0.844 mol mol(-1) if the pentose phosphate pathway (PPP), and transhydrogenase had a high flux under anaerobic condition. However, PPP had little influence on the theoretical 1,3-PD yield, and the flux through tricarboxylic acid (TCA) cycle was high under aerobic conditions. In addition, the effect of oxygen level on the 1,3-PD and biomass was further analyzed.
Klinische Immunologie (1984)

In früheren Arbeiten konnte gezeigt werden, daß in Seren von Patienten mit primär biliärer Zirrhose (PBC) verschiedene organunspezifische antimitochondriale Antikörper vorkommen (Anti-M2, Anti-M4, Anti-M8) [5]. Während Anti-M2-Antikörper ein wichtiger Parameter für die serologische Diagnose der PBC sind und bei 95% der PBC-Patienten gefunden wurden [4], scheinen Anti-M4- und Anti-M8-Antikörper auf eine progressive Form der Erkrankung hinzuweisen [5, 16].
Persistent Viruria due to Reovirus in a Patient Treated for Hodgkin's Disease in a Protected Environment (1970)

Journal Article Persistent Viruria due to Reovirus in a Patient Treated for Hodgkin's Disease in a Protected Environment Get access John H. Edmonson, John H. Edmonson From the Department of Medical Services of the Coney Island Hospital, affiliated with Maimonides Medical Center, Brooklyn, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Stephen J. Millian, Stephen J. Millian From the Department of Medical Services of the Coney Island Hospital, affiliated with Maimonides Medical Center, Brooklyn, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Maureen Goodenow, Maureen Goodenow From the Department of Medical Services of the Coney Island Hospital, affiliated with Maimonides Medical Center, Brooklyn, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Stanley L. Lee Stanley L. Lee From the Department of Medical Services of the Coney Island Hospital, affiliated with Maimonides Medical Center, Brooklyn, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 121, Issue 4, April 1970, Pages 438–441, https://doi.org/10.1093/infdis/121.4.438 Published: 01 April 1970 Article history Received: 28 October 1969 Revision received: 06 February 1970 Published: 01 April 1970
The global severity of chronic graft-versus-host disease, determined by National Institutes of Health consensus criteria, is associated with overall survival and non-relapse mortality (2011)

Patients with moderate to severe chronic graft-versus-host disease, as determined by National Institutes of Health Consensus criteria, have an inferior overall survival and worse non-relapse mortality. Clinical and research advances are needed to improve the outcomes of affected patients.
Novel linear polyene antibiotics: linearmycins (1996)

Two novel linear polyene antibiotics, termed linearmycin A 1 and B 2, have been isolated from the mycelial extracts of Streptomyces sp. no. 30 and characterized as compounds 1 and 2, respectively. These compounds have similar, long linear structures terminating with amino and carboxylic acid groups, and show antifungal and antibacterial activity. The incorporation experiments using 13C-labelled acetate and propionate suggest that 1 is biosynthesized from one γ-aminobutyric acid, 24 acetate and 4 propionate molecules, by a polyketide pathway.
HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G <sub>0</sub> /G <sub>1</sub> human hematopoietic stem cells (1998)

Recent studies have opened the possibility that quiescent, G0/G1 hematopoietic stem cells (HSC) can be gene transduced; lentiviruses (such as HIV type 1, HIV) encode proteins that permit transport of the viral genome into the nucleus of nondividing cells. We and others have recently demonstrated efficient transduction by using an HIV-1-based vector gene delivery system into various human cell types including human CD34(+) cells or terminally differentiated neurons. Here we compare the transduction efficiency of two vectors, HIV-based and murine leukemia virus (MuLV)-based vectors, on untreated and highly purified human HSC subsets that are virtually all in G0/G1. The HIV vector, but not MuLV vector supernatants, transduced freshly isolated G0/G1 HSC from mobilized peripheral blood. Single-step transduction using replication-defective HIV resulted in HSC that expressed the green fluorescent protein (GFP) transgene while retaining their stem cell phenotype; clonal outgrowths of these GFP+ HSC on bone marrow stromal cells fully retained GFP expression for at least 5 weeks. MuLV-based vectors did not transduce resting HSC, as measured by transgene expression, but did so readily when the HSC were actively cycling after culture in vitro for 3 days in a cytokine cocktail. These results suggest that resting HSC may be transduced by lentiviral-based, but not MuLV, vectors and maintain their primitive phenotype, pluripotentiality, and at least in vitro, transgene expression.