gebhart/patrepeval huggingface dataset:
LEAST SQUARE APPROACH FOR VOLTAGE CONTROL 0 PTI M I2 AT1 0 N (1990)

This paper describes the procedure for determination of optimum voltage control using the quadratic optimization technique based on least square method. The new approach is capable of handling generalized optimization problems with number of variables greater/equal, less than number of constraints. These constraints can be linear or non- linear but can be modelled as quadratic forms of voltage. Although the power system models are non-convex, non-concave and non-linear, the optimization scheme determines the feasible and global optimum points. The method is based on the sensitivity method with first order approximation of Taylor series to achieve the necessary and sufficient conditions extended from Kuhn Tucker conditions. To satisfy the generalized optimization scheme, the method is specialized to use a least square method for the determination of unknown quantities.The algorithm is tested using traditional optimization programs such as MlNOS Augmented programming, the generalized reduced gradient,and simplex like method (l). The capability of this method is being demonstrated on a medium sized power system.
24—ANALYSIS OF THE DRY-RELAXED KNITTED-LOOP CONFIGURATION: PART I: TWO-DIMENSIONAL ANALYSIS (1967)

Models of the relaxed plain-knit structure proposed by previous workers suffer from the disadvantage of being based on the assumption of some geometrical shape for the knitted loop and are not derived from equilibrium considerations of the forces and couples applied to one loop by its neighbours. In the work described in this paper, the dry-relaxed knitted-loop configuration is considered as a function of a system of localized forces and couples acting on the loop at the interlocking points in the fabric. The assumed system of forces and couples is derived from physical considerations of equilibrium and loop symmetry. In this paper, the loop is assumed to be plane (or two-dimensional), and its shape is analysed as a function of the forces acting in the plane of the fabric. The resultant loop configuration is discussed in relation to experimental work previously done on relaxed plain-knit fabrics. The analysis is to be extended to three dimensions in Part II.
Multiple primary left ventricular myxomas with multiple intraventricular recurrences. (1993)

A 23-year-old male was operated on for two primary left ventricular myxomas of the "complex" type. Ten months later, abnormal echo reappeared and reoperation was carried out to excise 2 recurrent myxomas in the left ventricle. Multiple foci were most likely responsible for the recurrence. No recurrence has been detected for 20 months postoperatively. This may be the first reported case of multiple primary left ventricular myxoma with multiple recurrences in the left ventricular cavity.
B6 Investigation of Finished Surface Machined by Ball Nose End-milling under Constant Contact Angle with a Five-axis Controlled Machining Center(Advanced machine tool) (2009)

In the present study, we dealt with a finishing machining plane surface by ball nose end-milling with a five-axis controlled machining center. The condition is a surface roughness constant of Rz 0.5 μm considering both feed and pick feed rates. In addition, this machining was performed under a constant angle between the tool and the workpiece. We propose a new method that reflects concentric circles as a method to evaluate the surface using a near-infrared radiation image. The setting of an appropriate amount of feed and pick was clearly necessary.
MexZ-mediated regulation of<i>mexXY</i>multidrug efflux pump expression in<i>Pseudomonas aeruginosa</i>by binding on the<i>mexZ-mexX</i>intergenic DNA (2004)

MexZ is a transcriptional regulator of the mexXY multidrug transporter operon, which confers aminoglycoside resistance on Pseudomonas aeruginosa. Highly purified MexZ showed direct binding with a specific site of the mexZ-mexX intergenic DNA when probed by a gel retardation assay. Both in vitro chemical cross-linking experiments and an in vivo two-hybrid expression system showed that the active form of MexZ, which is capable of binding the intergenic DNA, appeared to be a dimer. These results explain the mechanism by which MexZ represses transcription of the mexXY operon, but do not explain the substrate-induced hyperproduction of MexXY. The presence of inducer antibiotic in the gel-retardation assay mixture failed to detect altered MexZ-probe DNA interaction suggesting the possible involvement of an additional regulator.
Production of<scp>L</scp>-Tryptophan by 5-Fluorotryptophan Resistant Mutants of<i>Bacillus subtilis</i> (1973)

Journal Article Production of L-Tryptophan by 5-Fluorotryptophan Resistant Mutants of Bacillus subtilis Get access Isamu Shiio, Isamu Shiio Central Research Laboratories of Ajinomoto Co., Inc., Kawasaki, Japan Search for other works by this author on: Oxford Academic Google Scholar Kenji Ishii, Kenji Ishii Central Research Laboratories of Ajinomoto Co., Inc., Kawasaki, Japan Search for other works by this author on: Oxford Academic Google Scholar Kenzo Yokozeki Kenzo Yokozeki Central Research Laboratories of Ajinomoto Co., Inc., Kawasaki, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 37, Issue 9, 1 September 1973, Pages 1991–2000, https://doi.org/10.1080/00021369.1973.10860955 Published: 01 September 1973 Article history Received: 23 December 1972 Published: 01 September 1973
Cost-effective isobaric tagging for quantitative phosphoproteomics using DiART reagents (2013)

We describe the use of an isobaric tagging reagent, Deuterium isobaric Amine Reactive Tag (DiART), for quantitative phosphoproteomic experiments. Using DiART tagged custom mixtures of two phosphorylated peptides from alpha casein and their non-phosphorylated counterparts, we demonstrate the compatibility of DiART with TiO2 affinity purification of phosphorylated peptides. Comparison of theoretical vs. experimental reporter ion ratios reveals accurate quantification of phosphorylated peptides over a dynamic range of more than 15-fold. Using DiART labelling and TiO2 enrichment (DiART-TiO2) with large quantities of proteins (8 mg) from the cell lysate of model fungus Aspergillus nidulans, we quantified 744 unique phosphopeptides. Overlap of median values of TiO2 enriched phosphopeptides with theoretical values indicates accurate trends. Altogether these findings confirm the feasibility of performing quantitative phosphoproteomic experiments in a cost-effective manner using isobaric tagging reagents, DiART.
The impact of individual and methodological factors in the variability of response to methylphenidate in ADHD pharmacogenetic studies from four different continents. (2008)

Several studies have evaluated the association between individual polymorphisms and response to methylphenidate (MPH) in subjects with attention-deficit/hyperactivity disorder (ADHD). There are few replication studies for each polymorphism of interest and results are sometimes inconsistent in this field. Although data collection from multiple international sites would allow large sample sizes, this approach has been criticized for introducing sampling variability due to differences in ethnicity and methodology between studies. To examine these issues, we aggregated nine pharmacogenetic studies from four different continents and conducted a two stage analysis: (a) we evaluated the role of methodological aspects in the variability of ADHD symptom improvement between studies using meta-regression analysis; (b) we assessed the role of individual characteristics of the subjects in the variability of ADHD symptoms improvement using multivariate regression analysis in the same data sets. At the study level, from five evaluated factors, only the design of the study (open studies vs. randomized controlled trials) was significantly associated with heterogeneity of results (P = 0.001). At the individual level, age (P < 0.001), comorbid oppositional defiant disorder (P < 0.001), and pre-treatment scores (P < 0.001) were associated with change of ADHD scores with treatment in the final multivariate model. Our results suggest that joint analyses of pharmacogenetic studies are feasible and promising, since fixed variables, such as the site where the study was conducted, were not related to results. Nevertheless, stratified analyses according to the design of the study must be preferentially conducted and the role of individual factors such as demographic data and comorbid profile as confounders should be assessed.
Unique digital skin lesions associated with systemic sclerosis (1997)

A 40-year-old woman with systemic sclerosis presented with multiple, large soft skin lesions with a cystic appearance over the interphalangeal joints of both hands. Aspiration of one of these lesions revealed the presence of a yellowish mucoid material which rapidly reappeared. Surgical dissection and excision of the masses was followed by recurrence a few months later. Pre-operative diagnosis was that of myxoid cysts, but the histological picture was reminiscent of cutaneous focal mucinosis, another form of primary mucinosis. The origin of these unique skin lesions is unclear, but speculation on a possible aetiological relationship between them and systemic sclerosis is presented.
Nondestructive two-dimensional phase imaging of embedded defects via on-chip spintronic sensor (2012)

A microwave near field phase imaging technique has been achieved by an on-chip spintronic sensor. The sensor directly rectifies a microwave field into a dc voltage signal by employing the spintronic principle, in which the relative phase between microwave electric and magnetic fields plays an important role. By manipulating the relative phase, the sensor can nondestructively detect embedded defects of subwavelength size.
New Semiphysiological Absorption Model To Assess the Pharmacodynamic Profile of Cefuroxime Axetil Using Nonparametric and Parametric Population Pharmacokinetics (2009)

Cefuroxime axetil is widely used to treat respiratory tract infections. We are not aware of a population pharmacokinetic (PK) model for cefuroxime axetil. Our objectives were to develop a semiphysiological population PK model and evaluate the pharmacodynamic profile for cefuroxime axetil. Twenty-four healthy volunteers received 250 mg oral cefuroxime as a suspension after a standardized breakfast. Liquid chromatography-tandem mass spectrometry was used for drug analysis, NONMEM and S-ADAPT (results reported) were used for parametric population PK modeling, and NPAG was used for nonparametric population PK modeling. Monte Carlo simulations were used to predict the duration for which the non-protein-bound-plasma concentration was above the MIC (fT(>MIC)). A model with one disposition compartment, a saturable and time-dependent drug release from the stomach, and fast drug absorption from the intestine yielded precise (r > 0.992) and unbiased curve fits and an excellent predictive performance. The apparent clearance was 21.7 liters/h (19.8% coefficient of variation [CV]) and the volume of distribution 38.7 liters (18.3% CV). Robust (>or=90%) probabilities of target attainment (PTAs) were achieved by 250 mg cefuroxime given every 12 h (q12h) or q8h for MICs of <or=0.375 mg/liter or <or=0.5 mg/liter, respectively, for the bacteriostasis target fT(>MIC) of >or=40% and for MICs of <or=0.094 mg/liter or <or=0.375 mg/liter, respectively, for the near-maximal-killing target fT(>MIC) of >or=65%. For the >or=40% fT(>MIC) target, the PTAs for 250 mg cefuroxime q12h were >or=97.8% for Streptococcus pyogenes and penicillin-susceptible Streptococcus pneumoniae. Cefuroxime at 250 mg q12h or q8h achieved PTAs below 73% or 92%, respectively, for Haemophilus influenzae, Moraxella catarrhalis, and penicillin-intermediate S. pneumoniae for susceptibility data from various countries. Depending on the MIC distribution, 250 mg oral cefuroxime q8h instead of q12h should be considered, especially for more-severe infections that require near-maximal killing by cefuroxime.
A Strong Secular Trend in Serum Gamma-Glutamyltransferase from 1996 to 2003 among South Korean Men (2005)

Serum gamma-glutamyltransferase (GGT) concentration, within its normal range, has recently been proposed as a reliable marker of oxidative stress. Oxidative stress plays a central pathogenic role in many metabolic and/or cardiovascular diseases, incidences of which have recently increased in South Korea. Since serum GGT has strong associations with these diseases and their risk factors, the authors hypothesized a corresponding secular trend of increasing serum GGT levels in South Korea. Study subjects were 8,072 male workers at a large steel company who were aged 24-44 years at baseline and had received annual physical examinations from 1996 to 2003. The secular trend was a 0.1066-units/liter increase in ln(GGT) level per calendar year (a 180% increase during the 7-year follow-up period) (p < 0.01). Adjustment for body mass index, alcohol consumption, smoking, exercise, and cholesterol level as time-dependent covariates did not change the results. Although cholesterol is commonly used as a marker of epidemiologic transition, there was a less dramatic secular trend in ln(serum cholesterol) level, and it disappeared after adjustment for the secular trend in serum GGT. These findings suggest that serum GGT concentration can be used as a sensitive marker of epidemiologic transition, and they portend a continuing rise in incidences of metabolic and/or cardiovascular diseases in this population in the coming years.
Possibilities of Detecting Different Hydrate Phases by TG and DSC (1980)

Transformations of calciumbromide hydrates with different amounts of water of crystallization prepared at room temperature were studied by DSC, Measurements made in sample holders with airtight covers lead to the probability of the existence of CaBr2.3H2O.
Functional characterization of the trans-membrane domain interactions of the Sec61 protein translocation complex beta-subunit (2009)

Our results identify functionally important amino acids in the Sbh1p trans-membrane domain. In addition, our results provide additional support for the involvement of Sec61beta in processes unlinked to protein translocation.
The Genome of S-PM2, a “Photosynthetic” T4-Type Bacteriophage That Infects Marine <i>Synechococcus</i> Strains (2005)

Bacteriophage S-PM2 infects several strains of the abundant and ecologically important marine cyanobacterium Synechococcus. A large lytic phage with an isometric icosahedral head, S-PM2 has a contractile tail and by this criterion is classified as a myovirus (1). The linear, circularly permuted, 196,280-bp double-stranded DNA genome of S-PM2 contains 37.8% G+C residues. It encodes 239 open reading frames (ORFs) and 25 tRNAs. Of these ORFs, 19 appear to encode proteins associated with the cell envelope, including a putative S-layer-associated protein. Twenty additional S-PM2 ORFs have homologues in the genomes of their cyanobacterial hosts. There is a group I self-splicing intron within the gene encoding the D1 protein. A total of 40 ORFs, organized into discrete clusters, encode homologues of T4 proteins involved in virion morphogenesis, nucleotide metabolism, gene regulation, and DNA replication and repair. The S-PM2 genome encodes a few surprisingly large (e.g., 3,779 amino acids) ORFs of unknown function. Our analysis of the S-PM2 genome suggests that many of the unknown S-PM2 functions may be involved in the adaptation of the metabolism of the host cell to the requirements of phage infection. This hypothesis originates from the identification of multiple phage-mediated modifications of the host's photosynthetic apparatus that appear to be essential for maintaining energy production during the lytic cycle.
Engineering magnetic properties of Fe-Ni-B amorphous alloys (1979)

Amorphous alloys in the series (Fe <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> Ni <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</inf> ) <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">80</inf> B <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</inf> were prepared by melt spinning with 20 < x < 80<. Losses and permeabilities are reported for frequencies from 100 Hz to 100 kHz. The as-wound toroids showed an increase in losses and a decrease in permeability with increasing x, consistent with the increase in magnetostriction observed with increasing x. After stress relief annealing of the toroids, maximum losses were observed at x = 75. This composition corresponds to the composition at which the magnetic anneal anisotropy is maximum.
Geometric and physical considerations for realistic protein models (2005)

Protein structure is generally conceptualized as the global arrangement or of smaller, local motifs of helices, sheets, and loops. These regular, recurring secondary structural elements have well understood and standardized definitions in terms of amino acid backbone geometry and the manner in which hydrogen bonding requirements are satisfied. Recently, "tube" models have been proposed to explain protein secondary structure in terms of the geometrically optimal packing of a featureless cylinder. However, atomically detailed simulations demonstrate that such packing considerations alone are insufficient for defining secondary structure; both excluded volume and hydrogen bonding must be explicitly modeled for helix formation. These results have fundamental implications for the construction and interpretation of realistic and meaningful biomacromolecular models.
T cell coinhibition and immunotherapy in human breast cancer. (2012)

Costimulation and coinhibition generated by the B7 family and their receptor CD28 family have key roles in regulating T lymphocyte activation and tolerance. These pathways are very attractive therapeutic targets for human cancers including breast cancer. Gene polymorphisms of B7x (B7-H4/B7S1), PD-1 (CD279), and CTLA-4 (CD152) are associated with increased risk of developing breast cancer although the underlying mechanisms are unclear. In human breast cancer microenvironment, up-regulation of coinhibitory B7/CD28 members B7x, B7-H3 (CD276), and PD-L1 (B7-H1/CD274) on tumor cells as well as PD-1 and PD-L1 on tumor-infiltrating immune cells are emerging as immune evasion pathways. Chemotherapy can affect the expression of these molecules, and therefore may dampen the immune response against breast cancer. Immunotherapy targeting T cell coinhibition as monotherapy or combined with standard therapies are in early stages of clinical development, but hold great promise for treatment of human breast cancer.
Temporal Workload-Aware Replicated Partitioning for Social Networks (2014)

Most frequent and expensive queries in social networks involve multi-user operations such as requesting the latest tweets or news-feeds of friends. The performance of such queries are heavily dependent on the data partitioning and replication methodologies adopted by the underlying systems. Existing solutions for data distribution in these systems involve hashor graph-based approaches that ignore the multi-way relations among data. In this work, we propose a novel data partitioning and selective replication method that utilizes the temporal information in prior workloads to predict future query patterns. Our method utilizes the social network structure and the temporality of the interactions among its users to construct a hypergraph that correctly models multi-user operations. It then performs simultaneous partitioning and replication of this hypergraph to reduce the query span while respecting load balance and I/O load constraints under replication. To test our model, we enhance the Cassandra NoSQL system to support selective replication and we implement a social network application (a Twitter clone) utilizing our enhanced Cassandra. We conduct experiments on a cloud computing environment (Amazon EC2) to test the developed systems. Comparison of the proposed method with hash- and enhanced graph-based schemes indicate that it significantly improves latency and throughput.
Electrospun Poly(L-Lactic Acid) Nanofibres Loaded with Dexamethasone to Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells (2012)

Dexamethasone (Dex), a synthetic corticosteroid, was loaded into poly(L-lactic acid) (PLLA) nanofibrous scaffolds with a concentration of 0.333 wt% by electrospinning. The Dex-loaded PLLA nanofibres increased the mechanical strength in comparison with pure PLLA nanofibres. A sustained release profile for over 2 months with an initial burst release after 12 h of 17% was shown. Importantly, the amounts of Dex released from the PLLA nanofibres every 3 days were close to the ones used for the standard osteogenic medium. The sustained osteoinductive environment created by released Dex strongly differentiated human mesenchymal stem cells (hMSCs) cultured in the Ost(-Dex) medium. ALP activity, BSP expression and calcium deposition were significantly higher than those of the cells cultured on the PLLA scaffolds without Dex. A large amount of hydroxyapatite-like minerals was observed on the Dex-loaded PLLA scaffolds after 21 days culture. The cells on these scaffolds also indicated an osteoblastic morphology on the 14th day. Besides, these scaffolds slightly increased the cell proliferation comparing to the scaffolds without Dex. As such, the PLLA nanofibres loaded with 0.333 wt% Dex was an effective osteoinductive scaffold which acts as a promising strategy for bone treatment.
Subcutaneous Island Pedicle Flaps (1987)

• The subcutaneous island pedicle flap is a useful and reliably successful means of closing small- to medium-sized cutaneous excisional defects. It is especially useful in areas where primary closure could result in distortion of critical features. The technique is conceptually straightforward and offers advantages over skin grafting and transposition flaps. We describe our experience with 60 consecutive, successful subcutaneous island pedicle flaps. (<i>Arch Dermatol</i>1987;123:514-518)
Nitrate Removal Efficiency and Bacterial Community Dynamics in Denitrification Processes Using Poly (<sc>L</sc>-lactic acid) as the Solid Substrate (2011)

Laboratory-scale solid-phase denitrification (SPD) reactors for nitrate removal were constructed by acclimating activated sludge with poly (L-lactic acid) (PLLA) having weight-average molecular weights (M(w)) of 9,900, 12,000, and 45,100 g mol(-1). A good nitrate removal rate (3.5-5.3 mg NO(3)(-)-N g [dry wt](-1) h(-1)) was found in the reactor containing PLLA of 9,900 g mol(-1), whereas the other two reactors with the higher M(w) PLLA showed low nitrate removal efficiency. Microbial community dynamics in the low M(w) PLLA-acclimated reactor were studied by 16S rRNA gene-targeted PCR-denaturing gradient gel electrophoresis and quinone profiling. Nonmetric multidimensional scaling analyses of these data sets revealed a marked population shift during acclimation of the SPD reactor with low M(w) PLLA. The 16S rRNA gene clone library and culture-dependent analyses showed that bacteria belonging to the family Comamonadaceae predominated and played the primary role in denitrification in the PLLA-using reactor; however, none of the bacterial isolates from the reactor degraded PLLA. These results suggest that the nitrate removal property of the PLLA-using SPD reactor is attained through the bioavailability of hydrolysates released abiotically from the solid substrate.