gebhart/patrepeval huggingface dataset:
Initiation and maturation of I-Z-I bodies in the growth tips of transfected myotubes (1999)

While over a dozen I-Z-I proteins are expressed in postmitotic myoblasts and myotubes it is unclear how, when, or where these first assemble into transitory I-Z-I bodies (thin filament/Z-band precursors) and, a short time later, into definitive I-Z-I bands. By double-staining the growth tips of transfected myotubes expressing (a) MYC-tagged s-alpha-actinins (MYC/s-alpha-actinins) or (b) green fluorescent protein-tagged titin cap (GFP/T-cap) with antibodies against MYC and I-Z-I band proteins, we found that the de novo assembly of I-Z-I bodies and their maturation into I-Z-I bands involved relatively concurrent, cooperative binding and reconfiguration of, at a minimum, 5 integral Z-band molecules. These included s-alpha-actinin, nebulin, titin, T-cap and alpha-actin. Resolution of the approximately 1.0 microm polarized alpha-actin/nebulin/tropomyosin/troponin thin filament complexes occurred subsequent to the maturation of Z-bands into a dense tetragonal configuration. Of particular interest is finding that mutant MYC/s-alpha-actinin peptides (a) lacking spectrin-like repeats 1-4, or consisting of spectrin-like repeats 1-4 only, as well as (b) mutants/fragments lacking titin or alpha-actin binding sites, were promptly and exclusively incorporated into de novo assembling I-Z-I bodies and definitive I-Z-I bands as was exogenous full length MYC/s-alpha-actinin or GFP/T-cap.
Impaired thyrotrophin secretion following the administration of thyrotrophin-releasing hormone in type II diabetes mellitus (1986)

Serum thyrotrophin has been measured before and after the intravenous administration of 200 micrograms of thyrotrophin-releasing hormone in 91 white subjects (33 stable diabetic patients and 58 healthy controls), none of whom had any clinical evidence of thyroid or pituitary dysfunction. Seven of the diabetic subjects failed to achieve a rise of serum thyrotrophin of greater than 2 mU/l above basal concentrations, as compared with only one of the control subjects (P = 0.006). The difference in response between diabetics and controls was confined to patients with Type II (non-insulin-dependent) diabetes: thus 5 of 13 Type II patients and 2 of 20 Type I (insulin-dependent) patients failed to show a normal response to thyrotrophin releasing hormone injection. No significant effect of glycaemic control on thyrotrophin responses was noted. These results suggest that Type II diabetes mellitus may be a cause of impaired thyrotrophin secretion in patients with no clinical evidence of pituitary disease. The mechanism for this impaired pituitary hormone release remains to be clarified.
PNEUMOCOCCAL PERITONITIS IN ADOLESCENT GIRLS (1979)

Two cases of pneumococcal peritonitis, which occurred after puberty in previously healthy adolescent girls, are described. In each case, the infection was caused by a Type 1 tetracycline-resistant pneumococcus.
Editorial (1994)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTEditorialRobert C. MurphyRobert C. MurphyMore by Robert C. Murphy and Harry S. HertzHarry S. HertzMore by Harry S. HertzCite this: J Am Soc Mass Spectrom 1994, 5, 5, 331Publication Date (Print):May 1, 1994Publication History Published online1 May 1994Published inissue 1 May 1994https://pubs.acs.org/doi/10.1016/1044-0305(94)85047-Xhttps://doi.org/10.1016/1044-0305(94)85047-XeditorialACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views10Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (209 KB) Get e-Alerts
Beam Steering and Dynamic Focusing by Coherent Control of Light with Light on Metasurfaces (2020)

We report continuous ‘coherently controlled’ tuning of the wavefront of light scattered by phase-gradient silicon metasurfaces, which enables optical-frequency beam steering and dynamic focusing without moving parts.
Pharmacokinetic Features of the Antiparasitic Macrocyclic Lactones (2012)

The macrocyclic lactones have pharmacokinetic properties which enhance their use against endo- and ectoparasites in animals and man. The most consistent physico-chemical feature of the group which contributes to their kinetic characteristics is high lipid solubility. This appears to be necessary for their pharmacodynamic action as well as common kinetic features such as large volumes of distribution and the influence of body fat composition on their disposition. They are used in all domestic animal species and are undoubtedly influenced by the anatomical and physiological differences in these species, however body fat composition also appears to exert a major influence on distribution, metabolism and persistence between species and between breeds and individuals. A myriad of formulations have been developed to enhance the convenience of administration in the different domestic animals and the macrocyclic lactones are delivered orally, subcutaneously and topically to good effect. Lipid based excipients have been developed in "depot" formulations to extend the period of effective prevention of parasite re-infection. Subtle structural changes have been made to the macrocyclic lactone molecules to reduce distribution to the central nervous system and mammary gland, thus allowing use of some compounds such as selamectin (SLM) in "toxicity sensitive" breeds of collie dog which lack P-glycoprotein efflux systems in their central nervous systems and the use of eprinomectin (EPM) in dairy cattle with a nil-milk withdrawal period. Gender differences exist in the pharmacokinetics of these compounds which may be associated with body (fat) composition or metabolism. Feeding may also reduce the availability of macrocyclic lactones which bind particulate digestive material and parasitism may impact the kinetics of the drugs because parasitized animals have altered pathophysiological processes, especially in the gastro intestinal tract but also because of the impact which parasitism may have on the body condition (and fat deposition) in animals. The pharmacokinetics of macrocyclic lactones may be affected by coadministration with compounds which interfere with P-glycoprotein transporters and these interactions have been explored as possible mechanisms for enhancing the effectiveness of these antiparasitics. The objective of this article is to provide a comprehensive review of the pharmacokinetics of macrocyclic lactones and to interpret where that information may prove clinically useful.
ABRAHAM MODEL CORRELATIONS FOR PREDICTING GAS-TO-LIQUID PARTITION COEFFICIENTS AND ACTIVITY COEFFICIENTS OF ORGANIC SOLUTES DISSOLVED IN 1-(2-METHOXYETHYL)-1-METHYLPYRROLIDINIUM tris(PENTAFLUOROETHYL)TRIFLUOROPHOSPHATE (2013)

Chromatographic retention factors were measured for 45 different organic solutes of varying polarity and hydrogen-bonding capability on an anhydrous 1-(2-methoxyethyl)-1-methylpyrrolidinium tris(pentafluoroethyl)trifluorophosphate, ([MeoeMPyrr]+[FAP]–), stationary phase at both 323 K and 353 K. The experimental retention factor data were combined with recently published thermodynamic data for solutes dissolved in ([MeoeMPyrr]+[FAP]–) to give the corresponding gas-to-liquid partition coefficients (log K). The water-to-anhydrous ([MeoeMPyrr]+[FAP]–) partition coefficients (log P) were also calculated using published gas-to-water partition coefficient data for the solutes studied. The derived partition coefficients were analyzed in analyzed in accordance with the Abraham model. The Abraham model expressions that were obtained in the present study back-calculate the observed 105 log K and 104 log P values to within a standard deviation of 0.14 and 0.16 log units, respectively.
Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: A prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty‐five patients (2003)

These results suggest that 6 CY pulses are less effective than 12 CY pulses to treat severe PAN and MPA, particularly with respect to the risk of relapses.
Left ventricular function, aortic velocity, and late gadolinium enhancement assessed by real-time and single shot CMR is comparable to breath-held segmented imaging: a prospective study (2013)

Methods Thirteen patients referred to the CMR lab for evaluation of undiagnosed cardiomyopathy were prospectively enrolled. All patients were in regular cardiac rhythm and able to breath-hold. Standard segmented k-space images (including cine, velocity mapping (VM), and late-gadolinium enhancement (LGE)) were acquired during breathhold; real-time images (including cine, VM, and LGE) were acquired during free-breathing. Relevant imaging parameters are listed in Table 1. Breath-held and real-time studies for LGE were blinded and scored on a segmental basis for presence or absence of enhancement by two reviewers. LVEF was calculated using Simpson’s rule on short-axis BH cines, and biplane area-length methodology on long-axis RT cines. EF results were averaged across cardiac cycles when RT cine spanned more than one heartbeat. Peak velocity through the aortic valve was assessed in BH and RT images and compared. Maximum peak velocity was used when RT images spanned more than one heartbeat.
Une écriture de l'intime dans l'oeuvre latine de F. Pétrarque? (2019)

International audience
Notes (1950)

J. D. S. Goulden, A. Maccoll, D. J. Millen, G. R. Barker, G. F. Smith, R. N. Haszeldine, D. G. Harvey, E. D. Hughes and C. K. Ingold, J. Chem. Soc., 1950, 1635 DOI: 10.1039/JR9500001635
Diazepam Usage in Veterans With Spinal Cord Injury (1997)

Diazepam is widely prescribed for persons with spinal cord injury (SCI) to treat muscular spasticity. To assess the current usage of diazepam in those persons with SCI being followed by the Department of Veterans Affairs Medical Centers (DVAMCs), a survey was mailed to all 23 DVAMCs that have specialized SCI Services. We discovered that no policy regarding the prescription of benzodiazepines existed at 65 percent of the SCI Services. At 70 percent of the SCI Services, diazepam or another benzodiazepine was routinely prescribed. One-third of patients were estimated to have taken diazepam for greater than 10 years and an additional 37 percent for six to 10 years. Despite the potential for addiction, only 10 of the 23 SCI Services reported having a program to encourage discontinuation of diazepam use; a 20 percent success rate was reported in withdrawing this medication. A need for greater understanding with regard to the prescription of diazepam exists and strategies for its withdrawal should be considered. Appropriate guidelines for its use in patients with SCI and spasticity should be developed.
ChemInform Abstract: Intramolecular Reaction of Electrogenerated Phenoxy Cations with an Olefin Bearing an Electron‐Releasing Group at the Side Chain. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parallel windings in multiwinding transformers (1954)

THE GROWTH in size and complexity of power systems has resulted in a trend toward multiwinding transformers. A frequent consideration in the application of these multiwinding transformers is the possibility of paralleling secondary windings.
Spectral Ringing Artifacts in Hyperspectral Image Data Compression (2005)

When using 3-D wavelet transforms for hyperspectral image compression, systematic variations in signal level of different spectral bands can cause widely-varying mean values in spatial planes of spatially low-pass subbands. Failing to account for this phenomenon can have detrimental effects on image compression, including reduced effectiveness in compressing spatially low-pass subband data, and biases in some reconstructed spectral bands.
Electromagnetic analogies to general-Hamiltonian effective-mass electron wave propagation in semiconductors with spatially varying effective mass and potential energy (1992)

It is shown that exact, quantitative electromagnetic analogies exist for all forms of the general Hamiltonian [R. A. Morrow and K. R. Brownstein, Phys. Rev. B 30, 678 (1984)], which applies to single-band effective-mass electron wave propagation in semiconductors. It is further shown that these analogies are valid for propagation in the bulk, propagation past abrupt interfaces between materials, and propagation within one- and two-dimensionally inhomogeneous materials. These results indicate that the correct form of the single-band effective-mass Hamiltonian can be determined through appropriate wave-function-amplitude-sensitive experiments. Wave-function-phase-sensitive experiments (such as the measurement of electron wave refraction directions) are not adequate to specify completely the Hamiltonian. The present analogies suggest many wave-function-amplitude-sensitive experiments that can be used to determine the correct form of the Hamiltonian. The results of the present analysis are broadly applicable to general effective-mass propagation, unlike other recent work that has treated specific cases.
Seeding Date Effect on Rice Grain Yields in Arkansas and Louisiana (2003)

Seeding date has a substantial influence on rice ( Oryza sativa L.) grain yield. Previous studies, across the Midsouth rice producing area in the USA, have shown that rice grain yields decrease as the date of seeding is delayed. However, information quantifying the rate of yield decline has not been developed. The primary objective of this research was to determine the influence of seeding date on rice grain yield for two geographical areas in the USA. Yield data from Stuttgart, AR, and Crowley, LA, were compared for studies conducted in the 1990s with modern cultivars and from the 1960s and 1970s with older cultivars. Modern rice cultivars produced maximum grain yields when seeded from 16 February through 28 March at Crowley, LA, and 29 March through 26 April at Stuttgart, AR. Older cultivars grown in the 1960s and early 1970s showed similar, but slightly later optimum seeding dates. Quadratic equations best described the relationship between seeding date and relative grain yield by location and era. The rate of yield decline was the same in both Arkansas and Louisiana and for each era evaluated. The average daily high and low air temperatures for the predicted optimum seeding dates are 20 and 8°C at Crowley, LA, and 24 and 11°C at Stuttgart, AR. Rice seeded during the optimum period has a longer vegetative growth phase than later seeded rice. The relationship between seeding date and rice grain yield will aid growers in making crop planting decisions based on expected grain yields and commodity prices.
Homogeneous reductions of nitrogen-containing substrates catalyzed by molybdenum(IV) complexes with .mu.-sulfido ligands (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous reductions of nitrogen-containing substrates catalyzed by molybdenum(IV) complexes with .mu.-sulfido ligandsC. J. Casewit, D. E. Coons, L. L. Wright, W. K. Miller, and Mary Rakowski. DuBoisCite this: Organometallics 1986, 5, 5, 951–955Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/om00136a019https://doi.org/10.1021/om00136a019research-articleACS PublicationsRequest reuse permissionsArticle Views574Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Collective activity localization by spatiality preservation search (2016)

In this paper, we propose a collective activity localization method based on the spatial contextual information among people. In contrast to previous works of collective activity recognition, the collective activity localization method recognizes groups of people participating in a consistent activity as well as their activity labels. The biggest challenge of collective activity localization is efficient computation, due to exponential growth of the number of possible groups. The combinatorial search methods cannot be naively applied for collective activity localization, because the participant’s position dramatically changes by adding new participants to the groups. In this work, we introduce a novel search algorithm named the Spatiality Preservation Search (SPS), which provides exact solutions in polynomial time. By determining participants on the group boundaries first, the SPS enumerates groups without changing the participant’s position in the groups. Also, using Haar-like contextual descriptors, the SPS extracts groups efficiently using integral images. Experiments on an existing data-set and challenging new data-sets show efficiency of the proposed method.
Nocardia brasiliensis Infection Seen on Grafted Skin of the Dorsum of a Foot. (2001)

For the past 4 years a 23 y-old female has noticed erythema on the dorsum of the right foot, where skin was grafted due to a traffic accident 20 years ago. She visited the Department of Dermatology of Gifu Prefectural Hospital on Oct. 19, 1998; her general health was good. Physical examination disclosed a swelling with erythema, papules and pustules on the dorsum of the right foot. The results of routine laboratory investigations were within normal limits except for the white blood cell count (11,300/mm(3)), blood sediment rate (25 mm/hrs), C reactive protein (1.21) and rheumatoid factor (x 16.6). Several yellowish and verrucous or wrinkled colonies were grown on Sabourauds agar culture from the biopsied specimen of the foot. Histopathological features showed epidermal hyperplasia with elongation of rete ridges and granulomatous changes in the dermis; many mononuclear and giant cells were present, and several positive fine filamentous and irregularly branching structures with PAS and Grocott stains were seen in the granulomatous nests. Both clinical and histopathological features led to speculation of Nocardia infection, and Nocardia brasiliensis was determined. The patient was treated by surgical total resection including the grafted skin. Although a soybean-sized nodule was seen on the border of the skin-graft of the foot three months later, there was no recurrence after the local resection.
Stetter's Complexes are no Intramolecular Inclusion Compounds (1982)

Abstract The complete manuscript of this communication appears in: Angew. Chem. Suppl. 1982 , 1690. DOI: 10.1002/anie.198216900
Solitons in a nonlinear elastic medium (1991)

The influence of nonlinearity on shear horizontal elastic (bulk and surface) waves in crystals is considered on the basis of a nonlinear equation derived from a microscopic scalar model. The continuum limit is compared with the equation obtained in the framework of nonlinear elasticity theory. Using the equation, it is demonstrated that nonlinear surface waves of the shear horizontal polarization are modulationally unstable, and, therefore, they have to produce surface solitary waves. The solitons are studied in the case of a nonlinear elastic plate when the effective asymptotic technique may be elaborated. In the main approximation of the asymptotic approach, the effective nonlinear Schr\"odinger equation is derived. We predict that in the nonlinear elastic plate it is possible to observe bright or dark envelope solitons that propagate without distortion. The properties of the solitons depend on the carrier wave number and the thickness of the plate. We demonstrate also that there is a discrete set of the solitons produced by linear modes of the elastic plate.
RADIATIVE TRANSFER: A NEW LOOK OF THE OLD THEORY (2007)

This tutorial paper discusses electromagnetic scattering by random many-particle groups and summarizes the microphysical approach to radiative transfer and coherent backscattering. It provides a detailed discussion of the exact meaning of such fundamental concepts as single and multiple scattering and explains how the theories of radiative transfer and coherent backscattering originate in the macroscopic Maxwell equations. It also exposes and corrects certain misconceptions of the traditional phenomenological approach to radiative transfer.
Residual <i>cftr</i> Expression Varies with Age in <i>cftr<sup>tm1Hgu</sup></i> Cystic Fibrosis Mice: Impact on Morphology and Physiology (2002)

Mouse models for cystic fibrosis (CF) mimic intestinal manifestations of the human disease, but the lung disease phenotypes are lacking in most strains. In this work, the issue was addressed whether aging of the respiratory tract leads to lung pathophysiology in the exon 10 insertional mutant cftr(tm1Hgu) mouse. Weight gain, body weight and life-span of cftr(tm1Hgu) mice were significantly reduced compared with control mice. cftr(tm1Hgu) mice expressed 20, 21 or 37% (median) of wild-type cystic fibrosis conductance transmembrane regulator (cftr) mRNA transcript in lungs, intestine and kidney. Wild-type cftr mRNA in renal and respiratory epithelia varied with age from levels similar to Ztm:MF1 controls at the age of 2 and 4 months to levels seen in patients with CFTR splice mutations beyond the age of 6 months. The morphology of the bronchi and more distal airways was apparently normal in cftr(tm1Hgu) mice during their first year of life. The alveolar surfactant phospholipid pool was increased in cftr(tm1Hgu) mice by 1.5- to 2-fold compared with Ztm:MF1 controls. Alveolar clearance of gamma-labelled scandium oxide - the first report of lung clearance measurement in living mice - was reduced in cftr(tm1Hgu) mice compared with littermate controls. Although no progressive lung pathology was seen in the cftr expression of cftr(tm1Hgu) mice, surfactant phospholipid homeostasis, and alveolar and mucociliary clearance were abnormal. Therefore, the described model is useful for studying the initial CF lung pathophysiology.